TR10000_c0_g2_i1 Q5RCP3 NAA38_PONAB 1.00E-45 GO:0003723; GO:0008380; GO:0006397; GO:0005681 RNA binding; RNA splicing; mRNA processing; spliceosomal complex IPR010920; IPR001163; IPR006649; "N-alpha-acetyltransferase 38, NatC auxiliary subunit (U6 snRNA-associated Sm-like protein LSm8)" NAA38 LSM8 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR10004_c0_g1_i1 Q6P2X9 MOT12_XENTR 2.00E-15 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR10015_c0_g1_i1 P86963 KCP2_PINMA 3.00E-21 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; BPTI/Kunitz domain-containing protein 2 (Nacre serine protease inhibitor 1) (NSPI1) Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) TR10017_c1_g1_i1 Q9CZR2 NALD2_MOUSE 2.00E-14 GO:0050129; GO:0004180; GO:0016805; GO:0016021; GO:0046872; GO:0008237; GO:0042135; GO:0006508 N-formylglutamate deformylase activity; carboxypeptidase activity; dipeptidase activity; integral to membrane; metal ion binding; metallopeptidase activity; neurotransmitter catabolic process; proteolysis IPR007484; IPR003137; IPR007365; N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylaspartylglutamate peptidase II) (NAAG-peptidase II) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) Naalad2 Mus musculus (Mouse) TR10028_c1_g1_i1 P10160 IF5A1_RABIT 6.00E-57 GO:0005789; GO:0051028; GO:0005643; GO:0008612; GO:0045727; GO:0045901; GO:0045905; GO:0015031; GO:0043022; GO:0003746; GO:0006452 endoplasmic reticulum membrane; mRNA transport; nuclear pore; peptidyl-lysine modification to hypusine; positive regulation of translation; positive regulation of translational elongation; positive regulation of translational termination; protein transport; ribosome binding; translation elongation factor activity; translational frameshifting IPR012340; IPR014722; IPR019769; IPR001884; IPR020189; IPR008991; Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (eIF-4D) EIF5A Oryctolagus cuniculus (Rabbit) TR10031_c0_g1_i1 Q8NF91 SYNE1_HUMAN 9.00E-07 GO:0005794; GO:0007030; GO:0034993; GO:0003779; GO:0008219; GO:0090286; GO:0005856; GO:0016021; GO:0042692; GO:0090292; GO:0031965; GO:0005640; GO:0045211; GO:0042803; GO:0030017 Q9NRI5; O94901; Q9UH99 Golgi apparatus; Golgi organization; SUN-KASH complex; actin binding; cell death; cytoskeletal anchoring at nuclear membrane; cytoskeleton; integral to membrane; muscle cell differentiation; nuclear matrix anchoring at nuclear membrane; nuclear membrane; nuclear outer membrane; postsynaptic membrane; protein homodimerization activity; sarcomere IPR001589; IPR001715; IPR012315; IPR018159; IPR002017; Nesprin-1 (Enaptin) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) SYNE1 C6orf98 KIAA0796 KIAA1262 KIAA1756 MYNE1 Homo sapiens (Human) TR10041_c0_g1_i1 P22079 PERL_HUMAN 6.00E-24 GO:0005737; GO:0005615; GO:0020037; GO:0042744; GO:0046872; GO:0004601; GO:0006979 cytoplasm; extracellular space; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity; response to oxidative stress IPR010255; IPR002007; IPR019791; Lactoperoxidase (LPO) (EC 1.11.1.7) (Salivary peroxidase) (SPO) LPO SAPX Homo sapiens (Human) TR10041_c0_g2_i1 Q1ENI8 PXDN_CAEEL 2.00E-27 GO:0005576; GO:0020037; GO:0042744; GO:0046872; GO:0004601 extracellular region; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR000372; Peroxidasin homolog (EC 1.11.1.7) pxn-1 ZK994.3 Caenorhabditis elegans TR10047_c0_g1_i1 Q7TNJ2 ABCA7_RAT 6.00E-11 GO:0005524; GO:0006200; GO:0016887; GO:0000139; GO:0010008; GO:0016021; GO:0006909; GO:0005886 ATP binding; ATP catabolic process; ATPase activity; Golgi membrane; endosome membrane; integral to membrane; phagocytosis; plasma membrane IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 7 Abca7 Rattus norvegicus (Rat) TR10050_c1_g1_i1 Q5R573 RBL2A_PONAB 8.00E-71 GO:0005525; GO:0007264 GTP binding; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; Rab-like protein 2A RABL2A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR10052_c1_g1_i1 P23074 POL_SFV1 7.00E-06 GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0075713; GO:0030430; GO:0042025; GO:0046872; GO:0090305; GO:0006508; GO:0004523; GO:0046718; GO:0075732; GO:0019012 DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; establishment of integrated proviral latency; host cell cytoplasm; host cell nucleus; metal ion binding; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; viral entry into host cell; viral penetration into host nucleus; virion IPR001584; IPR012337; IPR002156; IPR000477; IPR001641; Pro-Pol polyprotein (Pr125Pol) [Cleaved into: Protease/Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (EC 3.4.23.-) (p87Pro-RT-RNaseH); Protease/Reverse transcriptase (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.4.23.-) (p65Pro-RT); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN) (p42In)] pol Simian foamy virus type 1 (SFVmac) (SFV-1) TR10059_c0_g1_i1 Q86WZ6 ZN227_HUMAN 8.00E-23 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 227 ZNF227 Homo sapiens (Human) TR10059_c0_g2_i1 A2T812 ZN287_PONPY 9.00E-22 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein 287 ZNF287 Pongo pygmaeus (Bornean orangutan) TR1006_c0_g1_i1 H2A0N4 PIF_PINMG 1.00E-15 GO:0008061; GO:0006030; GO:0005576 chitin binding; chitin metabolic process; extracellular region IPR002557; IPR002035; Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] Pinctada margaritifera (Black-lipped pearl oyster) TR10067_c0_g1_i1 Q16706 MA2A1_HUMAN 3.00E-15 GO:0000139; GO:0006491; GO:0030246; GO:0016799; GO:0001701; GO:0016021; GO:0001889; GO:0048286; GO:0006013; GO:0004572; GO:0007005; GO:0043687; GO:0018279; GO:0007585; GO:0007033; GO:0008270 "Golgi membrane; N-glycan processing; carbohydrate binding; hydrolase activity, hydrolyzing N-glycosyl compounds; in utero embryonic development; integral to membrane; liver development; lung alveolus development; mannose metabolic process; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity; mitochondrion organization; post-translational protein modification; protein N-linked glycosylation via asparagine; respiratory gaseous exchange; vacuole organization; zinc ion binding" IPR011013; IPR011330; IPR013780; IPR027291; IPR011682; IPR015341; IPR000602; Protein modification; protein glycosylation. "Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)" MAN2A1 MANA2 Homo sapiens (Human) TR10068_c0_g2_i1 Q8R1I1 QCR9_MOUSE 2.00E-07 GO:0006122; GO:0005743; GO:0005750 "mitochondrial electron transport, ubiquinol to cytochrome c; mitochondrial inner membrane; mitochondrial respiratory chain complex III" IPR008027; Cytochrome b-c1 complex subunit 9 (Complex III subunit 9) (Complex III subunit X) (Cytochrome c1 non-heme 7 kDa protein) (Ubiquinol-cytochrome c reductase complex 7.2 kDa protein) Uqcr10 Mus musculus (Mouse) TR10071_c0_g1_i1 Q8CEL2 CT026_MOUSE 3.00E-22 IPR016181; Uncharacterized protein C20orf26 homolog Mus musculus (Mouse) TR10079_c0_g1_i1 Q8N8E3 CE112_HUMAN 2.00E-06 GO:0005813; GO:0005737; GO:0060077; GO:0005886; GO:0097120 centrosome; cytoplasm; inhibitory synapse; plasma membrane; receptor localization to synapse IPR027831; Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46) CEP112 CCDC46 Homo sapiens (Human) TR10104_c0_g1_i1 P08548 LIN1_NYCCO 6.00E-09 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR10104_c1_g1_i1 P14381 YTX2_XENLA 6.00E-11 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR1012_c0_g1_i1 Q11212 ACT_SPOLI 6.00E-66 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; Actin (Fragment) Spodoptera littoralis (Egyptian cotton leafworm) TR1012_c0_g3_i1 P86700 ACT_CHIOP 1.00E-12 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; "Actin, muscle (Alpha-actin) (Fragments)" Chionoecetes opilio (Crab-beetle) TR10122_c0_g1_i1 Q1L9A2 OPA3_DANRE 6.00E-08 GO:0007626; GO:0005739; GO:0050881; GO:0031413 locomotory behavior; mitochondrion; musculoskeletal movement; regulation of buoyancy IPR010754; Optic atrophy 3 protein homolog opa3 si:dkey-12o15.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR10125_c0_g1_i1 Q9VXX8 RL371_DROME 3.00E-36 GO:0046872; GO:0019843; GO:0005840; GO:0003735; GO:0006412 metal ion binding; rRNA binding; ribosome; structural constituent of ribosome; translation IPR011331; IPR001569; IPR018267; IPR011332; Probable 60S ribosomal protein L37-A RpL37a CG9091 Drosophila melanogaster (Fruit fly) TR10127_c2_g1_i1 Q99JY3 GIMA4_MOUSE 3.00E-14 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Mus musculus (Mouse) TR10129_c0_g1_i1 P03934 TC1A_CAEEL 1.00E-12 GO:0003677; GO:0015074; GO:0004519; GO:0090305; GO:0005634; GO:0004803; GO:0006313 "DNA binding; DNA integration; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus; transposase activity; transposition, DNA-mediated" IPR002492; Transposable element Tc1 transposase tc1a tca T07D3.8 Caenorhabditis elegans TR10134_c0_g1_i1 Q8VIG3 RSPH1_MOUSE 2.00E-12 GO:0005694; GO:0005829; GO:0007126; GO:0005634 chromosome; cytosol; meiosis; nucleus IPR003409; Radial spoke head 1 homolog (Male meiotic metaphase chromosome-associated acidic protein) (Meichroacidin) (Testis-specific gene A2 protein) Rsph1 Tsga2 Mus musculus (Mouse) TR10137_c1_g1_i1 Q5IS76 ACHA6_PANTR 2.00E-10 GO:0015464; GO:0004889; GO:0005892; GO:0035095; GO:0030054; GO:0051899; GO:0007399; GO:0045211; GO:0014059; GO:0060084 acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; behavioral response to nicotine; cell junction; membrane depolarization; nervous system development; postsynaptic membrane; regulation of dopamine secretion; synaptic transmission involved in micturition IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 Pan troglodytes (Chimpanzee) TR10141_c0_g1_i1 Q5RFQ0 FCF1_PONAB 2.00E-101 GO:0005730; GO:0006364; GO:0032040 nucleolus; rRNA processing; small-subunit processome IPR006984; IPR002716; rRNA-processing protein FCF1 homolog FCF1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR10147_c3_g1_i1 P55824 FAF_DROME 5.00E-06 GO:0007349; GO:0005737; GO:0050829; GO:0009950; GO:0009790; GO:0006897; GO:0008354; GO:0008583; GO:0045824; GO:0045861; GO:0007097; GO:0048477; GO:0016579; GO:0004221; GO:0006511; GO:0004843; GO:0007601 cellularization; cytoplasm; defense response to Gram-negative bacterium; dorsal/ventral axis specification; embryo development; endocytosis; germ cell migration; mystery cell differentiation; negative regulation of innate immune response; negative regulation of proteolysis; nuclear migration; oogenesis; protein deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity; visual perception IPR016024; IPR018200; IPR001394; Probable ubiquitin carboxyl-terminal hydrolase FAF (EC 3.4.19.12) (Protein fat facets) (Ubiquitin thioesterase FAF) (Ubiquitin-specific-processing protease FAF) (Deubiquitinating enzyme FAF) faf CG1945 Drosophila melanogaster (Fruit fly) TR10150_c0_g1_i1 Q868T3 CCAPR_DROME 2.00E-13 GO:0018990; GO:0005887; GO:0008188; GO:0005000 "ecdysis, chitin-based cuticle; integral to plasma membrane; neuropeptide receptor activity; vasopressin receptor activity" IPR000276; IPR017452; IPR001817; Cardioacceleratory peptide receptor CcapR CG6111 Drosophila melanogaster (Fruit fly) TR10152_c2_g1_i1 Q10741 ADA10_BOVIN 4.00E-25 GO:0000139; GO:0005798; GO:0007219; GO:0051088; GO:0009986; GO:0051089; GO:0001701; GO:0016021; GO:0006509; GO:0004222; GO:0042117; GO:0007162; GO:0005634; GO:0005886; GO:0010820; GO:0030307; GO:0008284; GO:0014069; GO:0042803; GO:0019901; GO:0006468; GO:0034612; GO:0008270 Golgi membrane; Golgi-associated vesicle; Notch signaling pathway; PMA-inducible membrane protein ectodomain proteolysis; cell surface; constitutive protein ectodomain proteolysis; in utero embryonic development; integral to membrane; membrane protein ectodomain proteolysis; metalloendopeptidase activity; monocyte activation; negative regulation of cell adhesion; nucleus; plasma membrane; positive regulation of T cell chemotaxis; positive regulation of cell growth; positive regulation of cell proliferation; postsynaptic density; protein homodimerization activity; protein kinase binding; protein phosphorylation; response to tumor necrosis factor; zinc ion binding IPR027053; IPR001762; IPR024079; IPR001590; IPR002870; Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (Myelin-associated metalloproteinase) (CD antigen CD156c) ADAM10 MADM Bos taurus (Bovine) TR10161_c0_g2_i1 Q555I8 KIF9_DICDI 3.00E-06 GO:0005524; GO:0051297; GO:0005737; GO:0016021; GO:0005871; GO:0051661; GO:0005874; GO:0007019; GO:0003777; GO:0007018; GO:0007067; GO:0005635; GO:0008104; GO:0006810 ATP binding; centrosome organization; cytoplasm; integral to membrane; kinesin complex; maintenance of centrosome location; microtubule; microtubule depolymerization; microtubule motor activity; microtubule-based movement; mitosis; nuclear envelope; protein localization; transport IPR027640; IPR001752; IPR027417; Kinesin-related protein 9 (Kinesin family member 9) kif9 kin2 DDB_G0274603 Dictyostelium discoideum (Slime mold) TR10161_c1_g1_i1 Q6P9P6 KIF11_MOUSE 7.00E-55 GO:0005524; GO:0051301; GO:0005737; GO:0005871; GO:0003777; GO:0007018; GO:0007100; GO:0072686; GO:0019901; GO:0090307; GO:0005876; GO:0000922 ATP binding; cell division; cytoplasm; kinesin complex; microtubule motor activity; microtubule-based movement; mitotic centrosome separation; mitotic spindle; protein kinase binding; spindle assembly involved in mitosis; spindle microtubule; spindle pole IPR025901; IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) Kif11 Mus musculus (Mouse) TR10167_c0_g1_i2 O02414 DYL1_ANTCR 3.00E-56 GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0007017; GO:0003774 cilium; cytoplasm; dynein complex; microtubule; microtubule-based process; motor activity IPR019763; IPR001372; "Dynein light chain LC6, flagellar outer arm" Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR10170_c0_g1_i1 P19835 CEL_HUMAN 3.00E-09 GO:0047372; GO:0004091; GO:0046514; GO:0006707; GO:0005829; GO:0005615; GO:0009062; GO:0008201; GO:0030299; GO:0044258; GO:0030157; GO:0018350; GO:0004771; GO:0004806; GO:0006641 acylglycerol lipase activity; carboxylesterase activity; ceramide catabolic process; cholesterol catabolic process; cytosol; extracellular space; fatty acid catabolic process; heparin binding; intestinal cholesterol absorption; intestinal lipid catabolic process; pancreatic juice secretion; protein esterification; sterol esterase activity; triglyceride lipase activity; triglyceride metabolic process IPR002018; IPR019826; IPR019819; Bile salt-activated lipase (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (Bile salt-stimulated lipase) (BSSL) (Bucelipase) (Carboxyl ester lipase) (Cholesterol esterase) (Pancreatic lysophospholipase) (Sterol esterase) CEL BAL Homo sapiens (Human) TR10179_c0_g1_i1 Q9NUV9 GIMA4_HUMAN 1.00E-24 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR1018_c0_g1_i1 Q62189 SNRPA_MOUSE 5.00E-10 GO:0003723; GO:0000398; GO:0000166; GO:0017069; GO:0005681 "RNA binding; mRNA splicing, via spliceosome; nucleotide binding; snRNA binding; spliceosomal complex" IPR012677; IPR000504; IPR024888; U1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A) Snrpa Rnu1a-1 Mus musculus (Mouse) TR10180_c0_g1_i2 Q7RTX9 MOT14_HUMAN 2.00E-09 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR10183_c0_g1_i1 Q76CA2 ACTP2_CYMEC 1.00E-13 GO:0019835; GO:0044179; GO:0016021; GO:0006811; GO:0044218 cytolysis; hemolysis in other organism; integral to membrane; ion transport; other organism cell membrane IPR015926; Echotoxin-2 (Echt 2) Cymatium echo (Giant triton) (Monoplex echo) TR10186_c0_g1_i1 P19438 TNR1A_HUMAN 7.00E-08 GO:0000139; GO:0030424; GO:0009986; GO:0071392; GO:0071260; GO:0042742; GO:0016101; GO:0005615; GO:0009812; GO:0006954; GO:0005887; GO:0045121; GO:0019048; GO:0010629; GO:0050728; GO:0032715; GO:0005634; GO:0043123; GO:0045766; GO:0050729; GO:0033160; GO:0045944; GO:0032760; GO:0042511; GO:0006693; GO:0043234; GO:0051291; GO:0042981; GO:0043279; GO:0043200; GO:0045471; GO:0001666; GO:0032496; GO:0033013; GO:0005031 P28799; Q13546; P01375; Q15628 "Golgi membrane; axon; cell surface; cellular response to estradiol stimulus; cellular response to mechanical stimulus; defense response to bacterium; diterpenoid metabolic process; extracellular space; flavonoid metabolic process; inflammatory response; integral to plasma membrane; membrane raft; modulation by virus of host morphology or physiology; negative regulation of gene expression; negative regulation of inflammatory response; negative regulation of interleukin-6 production; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of angiogenesis; positive regulation of inflammatory response; positive regulation of protein import into nucleus, translocation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of Stat1 protein; prostaglandin metabolic process; protein complex; protein heterooligomerization; regulation of apoptotic process; response to alkaloid; response to amino acid stimulus; response to ethanol; response to hypoxia; response to lipopolysaccharide; tetrapyrrole metabolic process; tumor necrosis factor-activated receptor activity" IPR011029; IPR000488; IPR001368; IPR020419; "Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]" TNFRSF1A TNFAR TNFR1 Homo sapiens (Human) TR10190_c0_g1_i1 Q96KN4 FA84A_HUMAN 4.00E-07 IPR007053; Protein FAM84A (Neurologic sensory protein 1) (NSE1) FAM84A NSE1 Homo sapiens (Human) TR10190_c0_g2_i1 Q9UL19 TIG3_HUMAN 3.00E-20 GO:0016021; GO:0016042; GO:0008285; GO:0004623; GO:0006644 integral to membrane; lipid catabolic process; negative regulation of cell proliferation; phospholipase A2 activity; phospholipid metabolic process IPR007053; Retinoic acid receptor responder protein 3 (EC 3.1.1.-) (HRAS-like suppressor 4) (HRSL4) (RAR-responsive protein TIG3) (Retinoid-inducible gene 1 protein) (Tazarotene-induced gene 3 protein) RARRES3 RIG1 TIG3 Homo sapiens (Human) TR10191_c1_g1_i1 Q7TPV2 DZIP3_MOUSE 6.00E-08 GO:0003723; GO:0005737; GO:0016874; GO:0019902; GO:0016567; GO:0008270 RNA binding; cytoplasm; ligase activity; phosphatase binding; protein ubiquitination; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog) Dzip3 Kiaa0675 Mus musculus (Mouse) TR10200_c0_g2_i1 Q13233 M3K1_HUMAN 1.00E-10 GO:0005524; GO:0038095; GO:0008545; GO:0004709; GO:0002755; GO:0008637; GO:0043010; GO:0071260; GO:0005829; GO:0045087; GO:0030838; GO:0030334; GO:0034166; GO:0034134; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124; GO:0007179; GO:0042060; GO:0008270 P15056; P61962; O75369; P45985; Q12851 ATP binding; Fc-epsilon receptor signaling pathway; JUN kinase kinase activity; MAP kinase kinase kinase activity; MyD88-dependent toll-like receptor signaling pathway; apoptotic mitochondrial changes; camera-type eye development; cellular response to mechanical stimulus; cytosol; innate immune response; positive regulation of actin filament polymerization; regulation of cell migration; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor TLR1:TLR2 signaling pathway; toll-like receptor TLR6:TLR2 signaling pathway; transforming growth factor beta receptor signaling pathway; wound healing; zinc ion binding IPR016024; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR001841; IPR013083; IPR007527; Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) MAP3K1 MAPKKK1 MEKK MEKK1 Homo sapiens (Human) TR10205_c0_g1_i1 Q99JY3 GIMA4_MOUSE 9.00E-09 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Mus musculus (Mouse) TR10213_c0_g1_i1 P21328 RTJK_DROME 2.00E-15 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) TR10214_c0_g1_i1 Q9QZD9 EIF3I_MOUSE 4.00E-41 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0006446; GO:0003743; GO:0006413 Q6NZJ6 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; regulation of translational initiation; translation initiation factor activity; translational initiation IPR027525; IPR015943; IPR001680; IPR019775; IPR017986; Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36) Eif3i Eif3s2 Trip1 Mus musculus (Mouse) TR10217_c1_g1_i1 P11654 PO210_RAT 7.00E-11 GO:0005789; GO:0051028; GO:0031965; GO:0005643; GO:0046983; GO:0015031; GO:0017056 endoplasmic reticulum membrane; mRNA transport; nuclear membrane; nuclear pore; protein dimerization activity; protein transport; structural constituent of nuclear pore IPR003343; IPR008964; Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) Nup210 Gp210 Pom210 Rattus norvegicus (Rat) TR10221_c0_g1_i1 D4D891 AMPP1_TRIVH 1.00E-07 GO:0004177; GO:0009987; GO:0046872; GO:0008237; GO:0006508 aminopeptidase activity; cellular process; metal ion binding; metallopeptidase activity; proteolysis IPR000587; IPR000994; Probable Xaa-Pro aminopeptidase P (AMPP) (Aminopeptidase P) (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Prolidase) AMPP TRV_03327 Trichophyton verrucosum (strain HKI 0517) TR10232_c0_g1_i2 Q9XWD6 CED1_CAEEL 4.00E-06 GO:0031532; GO:0006915; GO:0009986; GO:0034620; GO:0042742; GO:0043652; GO:0045184; GO:0016021; GO:0001891; GO:0030670; GO:0001845; GO:0012501; GO:0031260; GO:0043654; GO:0005044 actin cytoskeleton reorganization; apoptotic process; cell surface; cellular response to unfolded protein; defense response to bacterium; engulfment of apoptotic cell; establishment of protein localization; integral to membrane; phagocytic cup; phagocytic vesicle membrane; phagolysosome assembly; programmed cell death; pseudopodium membrane; recognition of apoptotic cell; scavenger receptor activity IPR000742; IPR013032; IPR002049; IPR011489; IPR006212; Cell death abnormality protein 1 ced-1 Y47H9C.4 Caenorhabditis elegans TR10233_c0_g1_i1 P80226 FABPL_CHICK 5.00E-12 GO:0005737; GO:0008289; GO:0005215 cytoplasm; lipid binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; "Fatty acid-binding protein, liver (Fatty acid-binding protein 1) (Liver basic FABP) (LB-FABP) (Liver bile acid-binding protein) (L-BABP) (Liver-type fatty acid-binding protein) (L-FABP)" FABP1 Gallus gallus (Chicken) TR10242_c0_g2_i1 Q5RCY5 ASTE1_PONAB 2.00E-09 GO:0006281; GO:0004518; GO:0090305 DNA repair; nuclease activity; nucleic acid phosphodiester bond hydrolysis IPR026832; IPR006085; Protein asteroid homolog 1 ASTE1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR10245_c1_g1_i1 Q32L68 HM20B_BOVIN 3.00E-20 GO:0003677; GO:0007049; GO:0016568; GO:0005694; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cell cycle; chromatin modification; chromosome; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009071; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (SMARCE1-related protein) (HMG box-containing protein 20B) HMG20B SMARCE1R Bos taurus (Bovine) TR10246_c0_g1_i1 P16157 ANK1_HUMAN 6.00E-27 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR10250_c0_g1_i1 Q9XT77 SC5A6_RABIT 3.00E-63 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR001734; IPR018212; IPR019900; Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (Solute carrier family 5 member 6) SLC5A6 SMVT Oryctolagus cuniculus (Rabbit) TR10265_c0_g1_i1 Q5RJA1 RFX6_DANRE 1.00E-55 GO:0042593; GO:0005634; GO:0003310; GO:0003311; GO:0090104; GO:0045893; GO:0050796; GO:0044212; GO:0006351; GO:0003309 "glucose homeostasis; nucleus; pancreatic A cell differentiation; pancreatic D cell differentiation; pancreatic epsilon cell differentiation; positive regulation of transcription, DNA-dependent; regulation of insulin secretion; transcription regulatory region DNA binding; transcription, DNA-dependent; type B pancreatic cell differentiation" IPR003150; IPR011991; DNA-binding protein RFX6 (Regulatory factor X 6) rfx6 si:dkeyp-93d12.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR10268_c1_g1_i1 Q9H694 BICC1_HUMAN 8.00E-66 GO:0003723; GO:0007275; GO:0090090 RNA binding; multicellular organismal development; negative regulation of canonical Wnt receptor signaling pathway IPR004087; IPR004088; IPR001660; IPR013761; IPR021129; Protein bicaudal C homolog 1 (Bic-C) BICC1 Homo sapiens (Human) TR10270_c0_g1_i1 Q80ZA4 PKHL1_MOUSE 5.00E-26 GO:0016021 integral to membrane IPR008972; IPR019316; IPR013783; IPR014756; IPR002909; IPR011658; IPR006626; IPR011050; Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86) Pkhd1l1 Mus musculus (Mouse) TR10271_c0_g2_i1 P83553 DERM_BIOGL 4.00E-14 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR026645; Dermatopontin (Tyrosine-rich acidic matrix protein) (TRAMP) Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail) TR10272_c1_g1_i1 A6PWY4 WDR76_MOUSE 7.00E-07 IPR015943; IPR001680; IPR017986; WD repeat-containing protein 76 Wdr76 Mus musculus (Mouse) TR10278_c0_g1_i1 C9JUS1 CB090_HUMAN 1.00E-12 TR10285_c0_g1_i1 Q9JHU4 DYHC1_MOUSE 3.00E-56 GO:0005524; GO:0006200; GO:0016887; GO:0005794; GO:0005858; GO:0005813; GO:0003341; GO:0005737; GO:0033962; GO:0070062; GO:0030175; GO:0005874; GO:0003777; GO:0034063; GO:0006810 P07141 ATP binding; ATP catabolic process; ATPase activity; Golgi apparatus; axonemal dynein complex; centrosome; cilium movement; cytoplasm; cytoplasmic mRNA processing body assembly; extracellular vesicular exosome; filopodium; microtubule; microtubule motor activity; stress granule assembly; transport IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)" Dync1h1 Dhc1 Dnch1 Dnchc1 Dyhc Mus musculus (Mouse) TR10298_c0_g1_i1 P09884 DPOLA_HUMAN 2.00E-31 GO:0008408; GO:0051539; GO:0003677; GO:0006270; GO:0006269; GO:0003887; GO:0005658; GO:0008283; GO:0003682; GO:0005737; GO:0006303; GO:0006273; GO:0006272; GO:0046872; GO:0000084; GO:0019048; GO:0005635; GO:0016363; GO:0005730; GO:0005654; GO:0001882; GO:0000166; GO:0000083; GO:0000722; GO:0032201; GO:0019985 P03070; P04014; P27694; P10193 "3'-5' exonuclease activity; 4 iron, 4 sulfur cluster binding; DNA binding; DNA replication initiation; DNA replication, synthesis of RNA primer; DNA-directed DNA polymerase activity; alpha DNA polymerase:primase complex; cell proliferation; chromatin binding; cytoplasm; double-strand break repair via nonhomologous end joining; lagging strand elongation; leading strand elongation; metal ion binding; mitotic S phase; modulation by virus of host morphology or physiology; nuclear envelope; nuclear matrix; nucleolus; nucleoplasm; nucleoside binding; nucleotide binding; regulation of transcription involved in G1/S transition of mitotic cell cycle; telomere maintenance via recombination; telomere maintenance via semi-conservative replication; translesion synthesis" IPR006172; IPR017964; IPR006133; IPR006134; IPR004578; IPR024647; IPR023211; IPR012337; IPR015088; DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) POLA1 POLA Homo sapiens (Human) TR10304_c1_g1_i1 P97363 SPTC2_MOUSE 1.00E-41 GO:0046513; GO:0016021; GO:0005739; GO:0030170; GO:0004758; GO:0017059; GO:0046511; GO:0006686; GO:0046512 ceramide biosynthetic process; integral to membrane; mitochondrion; pyridoxal phosphate binding; serine C-palmitoyltransferase activity; serine C-palmitoyltransferase complex; sphinganine biosynthetic process; sphingomyelin biosynthetic process; sphingosine biosynthetic process IPR001917; IPR004839; IPR015424; IPR015421; IPR015422; Lipid metabolism; sphingolipid metabolism. Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2) Sptlc2 Lcb2 Mus musculus (Mouse) TR10306_c0_g1_i1 Q5T5X7 BEND3_HUMAN 4.00E-08 IPR018379; BEN domain-containing protein 3 BEND3 KIAA1553 Homo sapiens (Human) TR10326_c0_g1_i1 Q29S14 F18B1_BOVIN 4.00E-69 GO:0016021 integral to membrane IPR008564; Golgi apparatus membrane protein TVP23 homolog B TVP23B FAM18B FAM18B1 Bos taurus (Bovine) TR10327_c1_g1_i1 P86178 CSL2_ONCKE 6.00E-09 GO:0030246 carbohydrate binding IPR000922; L-rhamnose-binding lectin CSL2 Oncorhynchus keta (Chum salmon) (Salmo keta) TR10328_c0_g1_i1 Q5XIU1 ABTB1_RAT 2.00E-20 GO:0005737; GO:0005730; GO:0005886; GO:0003746 cytoplasm; nucleolus; plasma membrane; translation elongation factor activity IPR002110; IPR020683; IPR000210; IPR011333; IPR013069; Ankyrin repeat and BTB/POZ domain-containing protein 1 Abtb1 Rattus norvegicus (Rat) TR10337_c0_g1_i1 Q8BPN8 DMXL2_MOUSE 2.00E-25 GO:0030054; GO:0030672 cell junction; synaptic vesicle membrane IPR022033; IPR015943; IPR001680; IPR017986; DmX-like protein 2 (Rabconnectin-3) Dmxl2 Kiaa0856 Mus musculus (Mouse) TR10345_c1_g1_i1 Q17LW0 MYO7A_AEDAE 1.00E-36 GO:0005524; GO:0030048; GO:0030898; GO:0048800; GO:0008407; GO:0005737; GO:0035317; GO:0003774; GO:0016459; GO:0032027; GO:0007605 ATP binding; actin filament-based movement; actin-dependent ATPase activity; antennal morphogenesis; chaeta morphogenesis; cytoplasm; imaginal disc-derived wing hair organization; motor activity; myosin complex; myosin light chain binding; sensory perception of sound IPR019749; IPR014352; IPR019748; IPR000299; IPR018979; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; IPR001452; Myosin-VIIa (Protein crinkled) ck AAEL001220 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR10347_c0_g1_i1 P94459 PPSD_BACSU 6.00E-11 GO:0017000; GO:0016740 antibiotic biosynthetic process; transferase activity IPR010071; IPR009081; IPR025110; IPR020845; IPR000873; IPR001242; IPR010060; IPR006162; Plipastatin synthase subunit D (EC 2.3.1.-) (Peptide synthase 4) [Includes: ATP-dependent proline adenylase (ProA 1) (Proline activase 1); ATP-dependent glutamine adenylase (GlnA) (Glutamine activase); ATP-dependent tyrosine adenylase 2 (TyrA 2) (Tyrosine activase 2)] ppsD pps4 BSU18310 Bacillus subtilis (strain 168) TR10358_c0_g1_i1 Q09YG9 CTTB2_SAIBB 3.00E-19 GO:0005938; GO:0043197 cell cortex; dendritic spine IPR002110; IPR020683; IPR019131; Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Saimiri boliviensis boliviensis (Bolivian squirrel monkey) TR10377_c0_g1_i1 Q8N7X0 ADGB_HUMAN 3.00E-23 GO:0004198; GO:0020037; GO:0005622; GO:0005506; GO:0019825; GO:0015671; GO:0006508 calcium-dependent cysteine-type endopeptidase activity; heme binding; intracellular; iron ion binding; oxygen binding; oxygen transport; proteolysis IPR012292; IPR000048; IPR001300; Androglobin (Calpain-7-like protein) ADGB C6orf103 CAPN7L Homo sapiens (Human) TR10379_c1_g1_i1 Q3V0C5 UBP48_MOUSE 4.00E-12 GO:0008234; GO:0005737; GO:0005634; GO:0004221; GO:0006511 cysteine-type peptidase activity; cytoplasm; nucleus; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR006615; IPR018200; IPR001394; IPR000626; Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) (Deubiquitinating enzyme 48) (Ubiquitin thioesterase 48) (Ubiquitin-specific-processing protease 48) Usp48 Kiaa4202 Mus musculus (Mouse) TR10382_c1_g1_i1 Q99P66 CLCN5_CAVPO 2.00E-09 GO:0005524; GO:0000139; GO:0015297; GO:0010008; GO:0016021; GO:0005886; GO:0005247 ATP binding; Golgi membrane; antiporter activity; endosome membrane; integral to membrane; plasma membrane; voltage-gated chloride channel activity IPR000644; IPR014743; IPR001807; IPR002247; H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5) CLCN5 Cavia porcellus (Guinea pig) TR10382_c1_g2_i1 Q54AX6 CLCA_DICDI 3.00E-39 GO:0030554; GO:0034707; GO:0005247 adenyl nucleotide binding; chloride channel complex; voltage-gated chloride channel activity IPR000644; IPR014743; IPR001807; Chloride channel protein A clcA DDB_G0294096 Dictyostelium discoideum (Slime mold) TR10392_c1_g1_i1 Q09225 NRF6_CAEEL 2.00E-14 GO:0016021; GO:0008289; GO:0006869; GO:0007275; GO:0016747 "integral to membrane; lipid binding; lipid transport; multicellular organismal development; transferase activity, transferring acyl groups other than amino-acyl groups" IPR002656; IPR006621; Nose resistant to fluoxetine protein 6 (Protein nrf-6) nrf-6 C08B11.4 Caenorhabditis elegans TR10395_c0_g1_i1 Q9CZJ2 HS12B_MOUSE 1.00E-07 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR10397_c0_g1_i1 P54246 ACR5_CAEEL 6.00E-08 GO:0030054; GO:0005230; GO:0016021; GO:0045211 cell junction; extracellular ligand-gated ion channel activity; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; Acetylcholine receptor subunit alpha-type acr-5 acr-5 K03F8.2 Caenorhabditis elegans TR10400_c0_g1_i1 P62323 SMD3_XENLA 7.00E-30 GO:0008380; GO:0071208; GO:0006397; GO:0005634; GO:0030529 RNA splicing; histone pre-mRNA DCP binding; mRNA processing; nucleus; ribonucleoprotein complex IPR027141; IPR010920; IPR001163; IPR006649; Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3) snrpd3 Xenopus laevis (African clawed frog) TR10401_c0_g1_i1 Q24K15 ANGP4_BOVIN 7.00E-24 GO:0001525; GO:0005576 angiogenesis; extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) TR10401_c0_g1_i2 Q9WVH6 ANGP4_MOUSE 3.00E-23 GO:0048014; GO:0001525; GO:0071456; GO:0007492; GO:0005615; GO:0016525; GO:0043066; GO:0043537; GO:0045766; GO:0043536; GO:0030297; GO:0005172 Tie signaling pathway; angiogenesis; cellular response to hypoxia; endoderm development; extracellular space; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of blood vessel endothelial cell migration; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; transmembrane receptor protein tyrosine kinase activator activity; vascular endothelial growth factor receptor binding IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3) Angpt4 Agpt4 Ang3 Mus musculus (Mouse) TR10405_c0_g1_i1 Q2KI13 SGSM3_BOVIN 4.00E-14 GO:0005097; GO:0017137; GO:0032486; GO:0007050; GO:0005737; GO:0005921; GO:0032851; GO:0045732 Rab GTPase activator activity; Rab GTPase binding; Rap protein signal transduction; cell cycle arrest; cytoplasm; gap junction; positive regulation of Rab GTPase activity; positive regulation of protein catabolic process IPR000195; IPR004012; IPR001452; Small G protein signaling modulator 3 (RUN and TBC1 domain-containing protein 3) SGSM3 RUTBC3 Bos taurus (Bovine) TR10409_c0_g1_i1 P21328 RTJK_DROME 2.00E-07 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) TR10416_c0_g1_i1 B3RNE8 ATAT_TRIAD 1.00E-26 GO:0071929; GO:0070507; GO:0019799 alpha-tubulin acetylation; regulation of microtubule cytoskeleton organization; tubulin N-acetyltransferase activity IPR007965; Alpha-tubulin N-acetyltransferase (Alpha-TAT) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog) TRIADDRAFT_53139 Trichoplax adhaerens (Trichoplax reptans) TR10417_c2_g1_i1 Q9NYT6 ZN226_HUMAN 1.00E-11 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 226 ZNF226 Homo sapiens (Human) TR10417_c2_g2_i1 Q8BXX2 ZBT49_MOUSE 1.00E-09 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) Zbtb49 Zfp509 Znf509 Mus musculus (Mouse) TR10418_c0_g1_i1 Q5T6X5 GPC6A_HUMAN 2.00E-10 GO:0004930; GO:0019722; GO:0009986; GO:0016021; GO:0005886; GO:0043200 G-protein coupled receptor activity; calcium-mediated signaling; cell surface; integral to membrane; plasma membrane; response to amino acid stimulus IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR028082; G-protein coupled receptor family C group 6 member A (hGPRC6A) (G-protein coupled receptor GPCR33) (hGPCR33) GPRC6A Homo sapiens (Human) TR10419_c0_g1_i1 Q9Y566 SHAN1_HUMAN 6.00E-22 GO:0030160; GO:0017146; GO:0017124; GO:0071532; GO:0008306; GO:0030054; GO:0005737; GO:0007016; GO:0060997; GO:0050894; GO:0060076; GO:0046959; GO:0042802; GO:0035255; GO:0007616; GO:0032232; GO:0050885; GO:0097481; GO:0042048; GO:0060999; GO:2000463; GO:0045211; GO:0008022; GO:0006461; GO:0032403; GO:0035418; GO:2000311; GO:0060013; GO:0097110; GO:0035176; GO:0031877; GO:0060074; GO:0071625 GKAP/Homer scaffold activity; N-methyl-D-aspartate selective glutamate receptor complex; SH3 domain binding; ankyrin repeat binding; associative learning; cell junction; cytoplasm; cytoskeletal anchoring at plasma membrane; dendritic spine morphogenesis; determination of affect; excitatory synapse; habituation; identical protein binding; ionotropic glutamate receptor binding; long-term memory; negative regulation of actin filament bundle assembly; neuromuscular process controlling balance; neuronal postsynaptic density; olfactory behavior; positive regulation of dendritic spine development; positive regulation of excitatory postsynaptic membrane potential; postsynaptic membrane; protein C-terminus binding; protein complex assembly; protein complex binding; protein localization to synapse; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; righting reflex; scaffold protein binding; social behavior; somatostatin receptor binding; synapse maturation; vocalization behavior IPR002110; IPR020683; IPR001478; IPR001660; IPR013761; IPR021129; IPR011511; IPR001452; SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) SHANK1 Homo sapiens (Human) TR10423_c0_g1_i1 Q03001 DYST_HUMAN 4.00E-20 GO:0031673; GO:0030018; GO:0015629; GO:0030424; GO:0007409; GO:0009925; GO:0005604; GO:0005509; GO:0007155; GO:0005938; GO:0007050; GO:0031252; GO:0048870; GO:0016023; GO:0031122; GO:0005829; GO:0005789; GO:0030198; GO:0030056; GO:0031581; GO:0016021; GO:0007229; GO:0005882; GO:0045111; GO:0045104; GO:0030011; GO:0015630; GO:0000226; GO:0035371; GO:0051010; GO:0060053; GO:0005635; GO:0005634; GO:0042803; GO:0031110; GO:0009611; GO:0008090 Q9UKG1; Q9NRI5; Q15691; Q61166; Q96CV9 H zone; Z disc; actin cytoskeleton; axon; axonogenesis; basal plasma membrane; basement membrane; calcium ion binding; cell adhesion; cell cortex; cell cycle arrest; cell leading edge; cell motility; cytoplasmic membrane-bounded vesicle; cytoplasmic microtubule organization; cytosol; endoplasmic reticulum membrane; extracellular matrix organization; hemidesmosome; hemidesmosome assembly; integral to membrane; integrin-mediated signaling pathway; intermediate filament; intermediate filament cytoskeleton; intermediate filament cytoskeleton organization; maintenance of cell polarity; microtubule cytoskeleton; microtubule cytoskeleton organization; microtubule plus end; microtubule plus-end binding; neurofilament cytoskeleton; nuclear envelope; nucleus; protein homodimerization activity; regulation of microtubule polymerization or depolymerization; response to wounding; retrograde axon cargo transport IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; IPR003108; IPR001101; IPR018159; IPR002017; Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) DST BP230 BP240 BPAG1 DMH DT KIAA0728 Homo sapiens (Human) TR10439_c0_g1_i1 Q8MSU3 FRRS1_DROME 1.00E-07 GO:0000293; GO:0016021 ferric-chelate reductase activity; integral to membrane IPR006593; IPR005018; IPR002861; Putative ferric-chelate reductase 1 homolog (DmSDR2) (EC 1.-.-.-) CG8399 Drosophila melanogaster (Fruit fly) TR10448_c1_g1_i1 Q9H4L4 SENP3_HUMAN 4.00E-15 GO:0071339; GO:0005737; GO:0005730; GO:0006508; GO:0004843 P06748; Q8IZL8; Q9NXF1; P0CG48; Q9BV38 MLL1 complex; cytoplasm; nucleolus; proteolysis; ubiquitin-specific protease activity IPR003653; Sentrin-specific protease 3 (EC 3.4.22.68) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) SENP3 SSP3 SUSP3 Homo sapiens (Human) TR10449_c0_g1_i1 O60755 GALR3_HUMAN 7.00E-11 GO:0007631; GO:0004966; GO:0016021; GO:0007611; GO:0007194; GO:0005886 feeding behavior; galanin receptor activity; integral to membrane; learning or memory; negative regulation of adenylate cyclase activity; plasma membrane IPR000405; IPR003908; IPR000276; IPR017452; Galanin receptor type 3 (GAL3-R) (GALR-3) GALR3 GALNR3 Homo sapiens (Human) TR10451_c0_g1_i1 P41437 IAP3_NPVOP 5.00E-14 GO:0006915; GO:0016874; GO:0039648; GO:0008270 apoptotic process; ligase activity; modulation by virus of host protein ubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; E3 ubiquitin-protein ligase IAP-3 (EC 6.3.2.-) (IAP-3) IAP3 IAP ORF35 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) TR10454_c0_g1_i1 Q2IBA2 CTTB2_CHLAE 2.00E-12 GO:0005938; GO:0043197 cell cortex; dendritic spine IPR002110; IPR020683; IPR019131; Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) TR10461_c1_g1_i1 Q7XPJ0 KCBP_ORYSJ 2.00E-12 GO:0005524; GO:0005871; GO:0003777; GO:0007018; GO:0016491 ATP binding; kinesin complex; microtubule motor activity; microtubule-based movement; oxidoreductase activity IPR019749; IPR014352; IPR019748; IPR000299; IPR018979; IPR027640; IPR019821; IPR001752; IPR000857; IPR027417; IPR011254; Kinesin-like calmodulin-binding protein homolog Os04g0666900 LOC_Os04g57140 OSJNBa0087O24.20 Oryza sativa subsp. japonica (Rice) TR10468_c2_g1_i1 Q6ZPR4 KCNT1_MOUSE 2.00E-12 GO:0015269; GO:0005249; GO:0008076 calcium-activated potassium channel activity; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR013099; IPR003929; IPR016040; Potassium channel subfamily T member 1 Kcnt1 Kiaa1422 Mus musculus (Mouse) TR10479_c0_g1_i1 P35448 TSP1_XENLA 3.00E-14 GO:0005509; GO:0007155; GO:0005576; GO:0008201; GO:0016529 calcium ion binding; cell adhesion; extracellular region; heparin binding; sarcoplasmic reticulum IPR026823; IPR008985; IPR013320; IPR000742; IPR013032; IPR024731; IPR001791; IPR000884; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-1 thbs1 tsp1 Xenopus laevis (African clawed frog) TR10484_c0_g1_i1 E9Q555 RN213_MOUSE 2.00E-08 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) Rnf213 Mus musculus (Mouse) TR10489_c1_g1_i1 P20595 GCYB1_RAT 5.00E-13 GO:0005525; GO:0051879; GO:0004383; GO:0008074; GO:0020037; GO:0043231; GO:0043167; GO:0046872; GO:0007263; GO:0046982 P31016 "GTP binding; Hsp90 protein binding; guanylate cyclase activity; guanylate cyclase complex, soluble; heme binding; intracellular membrane-bounded organelle; ion binding; metal ion binding; nitric oxide mediated signal transduction; protein heterodimerization activity" IPR001054; IPR018297; IPR011645; IPR011644; IPR024096; Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit) Gucy1b3 Guc1b3 Gucy1b1 Rattus norvegicus (Rat) TR10494_c0_g1_i1 O54694 SPTC2_CRIGR 4.00E-68 GO:0009058; GO:0005789; GO:0016021; GO:0030170; GO:0004758; GO:0006665 biosynthetic process; endoplasmic reticulum membrane; integral to membrane; pyridoxal phosphate binding; serine C-palmitoyltransferase activity; sphingolipid metabolic process IPR001917; IPR004839; IPR015424; IPR015421; IPR015422; Lipid metabolism; sphingolipid metabolism. Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2) SPTLC2 LCB2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR10494_c0_g2_i1 Q55FL5 SPTC1_DICDI 8.00E-14 GO:0016021; GO:0030170; GO:0004758; GO:0017059; GO:0030148 integral to membrane; pyridoxal phosphate binding; serine C-palmitoyltransferase activity; serine C-palmitoyltransferase complex; sphingolipid biosynthetic process IPR004839; IPR015424; IPR015421; Lipid metabolism; sphingolipid metabolism. Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1) sptA DDB_G0268056 Dictyostelium discoideum (Slime mold) TR10496_c0_g1_i1 Q5YCC5 TMC7_CHICK 2.00E-07 GO:0016021; GO:0006811 integral to membrane; ion transport IPR012496; Transmembrane channel-like protein 7 Tmc7 Gallus gallus (Chicken) TR10499_c0_g1_i1 D8VNS8 FCNV2_CERRY 3.00E-30 GO:0005576 extracellular region IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ryncolin-2 Cerberus rynchops (Dog-faced water snake) TR10500_c0_g1_i1 B1AVY7 KI16B_MOUSE 5.00E-65 GO:0005524; GO:0006895; GO:0005769; GO:0031901; GO:0045022; GO:0007492; GO:0007173; GO:0008543; GO:0001704; GO:0005871; GO:0005874; GO:0007018; GO:0005547; GO:0043325; GO:0080025; GO:0032266; GO:0008574; GO:0032801; GO:0001919 "ATP binding; Golgi to endosome transport; early endosome; early endosome membrane; early endosome to late endosome transport; endoderm development; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; formation of primary germ layer; kinesin complex; microtubule; microtubule-based movement; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding; plus-end-directed microtubule motor activity; receptor catabolic process; regulation of receptor recycling" IPR000253; IPR027640; IPR019821; IPR001752; IPR027417; IPR001683; IPR008984; Kinesin-like protein KIF16B Kif16b Kiaa1590 Mus musculus (Mouse) TR10504_c0_g1_i1 Q9Y6C5 PTC2_HUMAN 5.00E-19 GO:0008544; GO:0042633; GO:0097108; GO:0008158; GO:0016021; GO:0045879 epidermis development; hair cycle; hedgehog family protein binding; hedgehog receptor activity; integral to membrane; negative regulation of smoothened signaling pathway IPR003392; IPR000731; IPR004766; Protein patched homolog 2 (PTC2) PTCH2 UNQ560/PRO1121/PRO57079 Homo sapiens (Human) TR10509_c0_g1_i1 Q6GM71 LRWD1_XENLA 2.00E-07 GO:0006260; GO:0005721; GO:0003682; GO:0016568; GO:0006325; GO:0005737; GO:0071169; GO:0008327; GO:0035064; GO:0005815; GO:0005664; GO:0031933 DNA replication; centromeric heterochromatin; chromatin binding; chromatin modification; chromatin organization; cytoplasm; establishment of protein localization to chromatin; methyl-CpG binding; methylated histone residue binding; microtubule organizing center; nuclear origin of replication recognition complex; telomeric heterochromatin IPR001611; IPR015943; IPR001680; IPR019775; IPR017986; Leucine-rich repeat and WD repeat-containing protein 1 (ORC-associated protein) (ORCA) (Origin recognition complex-associated protein) lrwd1 orca Xenopus laevis (African clawed frog) TR10512_c1_g1_i1 P14099 PDE2A_BOVIN 5.00E-33 GO:0046038; GO:0005794; GO:0006198; GO:0019933; GO:0030553; GO:0046069; GO:0019934; GO:0004118; GO:0071321; GO:0035690; GO:0097011; GO:0036006; GO:0071260; GO:0005829; GO:0008144; GO:0005783; GO:0061028; GO:0046872; GO:0005759; GO:0030818; GO:0033159; GO:0000122; GO:0043116; GO:0005634; GO:0048471; GO:0050729; GO:0043117; GO:0042734; GO:0006626 "GMP catabolic process; Golgi apparatus; cAMP catabolic process; cAMP-mediated signaling; cGMP binding; cGMP catabolic process; cGMP-mediated signaling; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cellular response to cGMP; cellular response to drug; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cellular response to macrophage colony-stimulating factor stimulus; cellular response to mechanical stimulus; cytosol; drug binding; endoplasmic reticulum; establishment of endothelial barrier; metal ion binding; mitochondrial matrix; negative regulation of cAMP biosynthetic process; negative regulation of protein import into nucleus, translocation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of vascular permeability; nucleus; perinuclear region of cytoplasm; positive regulation of inflammatory response; positive regulation of vascular permeability; presynaptic membrane; protein targeting to mitochondrion" IPR003018; IPR003607; IPR023088; IPR002073; IPR023174; "cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)" PDE2A Bos taurus (Bovine) TR10521_c1_g1_i1 A2ASS6 TITIN_MOUSE 4.00E-08 GO:0005524; GO:0031430; GO:0030018; GO:0007512; GO:0055003; GO:0043056; GO:0003007; GO:0001701; GO:0046872; GO:0006936; GO:0005859; GO:0005634; GO:0018108; GO:0004674; GO:0004713; GO:1901897; GO:0045214; GO:0001756; GO:0005200 ATP binding; M band; Z disc; adult heart development; cardiac myofibril assembly; forward locomotion; heart morphogenesis; in utero embryonic development; metal ion binding; muscle contraction; muscle myosin complex; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of relaxation of cardiac muscle; sarcomere organization; somitogenesis; structural constituent of cytoskeleton IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) TR10522_c0_g3_i1 Q66J78 ID2B_XENLA 3.00E-11 GO:0043425; GO:0090398; GO:0005737; GO:0048557; GO:0061031; GO:2000178; GO:0045665; GO:0000122; GO:0048663; GO:0005634; GO:0045777; GO:0071158; GO:0048661; GO:0045893; GO:0043234 "bHLH transcription factor binding; cellular senescence; cytoplasm; embryonic digestive tract morphogenesis; endodermal digestive tract morphogenesis; negative regulation of neural precursor cell proliferation; negative regulation of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; neuron fate commitment; nucleus; positive regulation of blood pressure; positive regulation of cell cycle arrest; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; protein complex" IPR011598; IPR026052; DNA-binding protein inhibitor ID-2-B (Inhibitor of DNA binding 2-B) id2-b Xenopus laevis (African clawed frog) TR10530_c1_g1_i1 Q7Z4K8 TRI46_HUMAN 2.00E-07 GO:0005622; GO:0008270 intracellular; zinc ion binding IPR001870; IPR008985; IPR017903; IPR003961; IPR013783; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; "Tripartite motif-containing protein 46 (Gene Y protein) (GeneY) (Tripartite, fibronectin type-III and C-terminal SPRY motif protein)" TRIM46 TRIFIC Homo sapiens (Human) TR10534_c0_g1_i1 Q5GIG6 TNI3K_MOUSE 7.00E-16 GO:0005524; GO:0005737; GO:0046872; GO:0005634; GO:0004674 ATP binding; cytoplasm; metal ion binding; nucleus; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR017441; IPR001245; Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (TNNI3-interacting kinase) Tnni3k Cark Mus musculus (Mouse) TR10538_c2_g1_i1 Q9VUL9 FUCTA_DROME 8.00E-21 GO:0033932; GO:0032580; GO:0005797; GO:0036071; GO:0018392; GO:0016021; GO:0007399; GO:0006486 Q9VG62 "1,3-alpha-L-fucosidase activity; Golgi cisterna membrane; Golgi medial cisterna; N-glycan fucosylation; glycoprotein 3-alpha-L-fucosyltransferase activity; integral to membrane; nervous system development; protein glycosylation" IPR001503; Protein modification; protein glycosylation. "Glycoprotein 3-alpha-L-fucosyltransferase A (EC 2.4.1.214) (Core alpha-(1,3)-fucosyltransferase)" FucTA CG6869 Drosophila melanogaster (Fruit fly) TR10552_c0_g2_i1 Q0VFV7 KCTD7_DANRE 6.00E-17 GO:0005829; GO:0005886; GO:0051260 cytosol; plasma membrane; protein homooligomerization IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein KCTD7 kctd7 zgc:136884 Danio rerio (Zebrafish) (Brachydanio rerio) TR10553_c1_g1_i1 P41035 IF2B_RABIT 2.00E-43 GO:0046872; GO:0003743 metal ion binding; translation initiation factor activity IPR002735; IPR016189; IPR016190; Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta) EIF2S2 EIF2B Oryctolagus cuniculus (Rabbit) TR10562_c0_g1_i1 Q9UHC1 MLH3_HUMAN 5.00E-19 GO:0005524; GO:0016887; GO:0032390; GO:0032407; GO:0019237; GO:0005712; GO:0003682; GO:0007144; GO:0001673; GO:0007140; GO:0006298; GO:0030983; GO:0008104; GO:0007131; GO:0003696; GO:0003697; GO:0000795; GO:0007130 ATP binding; ATPase activity; MutLbeta complex; MutSalpha complex binding; centromeric DNA binding; chiasma; chromatin binding; female meiosis I; male germ cell nucleus; male meiosis; mismatch repair; mismatched DNA binding; protein localization; reciprocal meiotic recombination; satellite DNA binding; single-stranded DNA binding; synaptonemal complex; synaptonemal complex assembly IPR013507; IPR014762; IPR002099; IPR003594; IPR014790; IPR020568; IPR014721; DNA mismatch repair protein Mlh3 (MutL protein homolog 3) MLH3 Homo sapiens (Human) TR10564_c1_g1_i1 Q9VLS1 KPBB_DROME 3.00E-73 GO:0005977; GO:0004553; GO:0005886 "glycogen metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; plasma membrane" IPR008928; IPR012341; IPR011613; IPR008734; Glycan biosynthesis; glycogen metabolism. Probable phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta) CG8475 Drosophila melanogaster (Fruit fly) TR10565_c0_g2_i1 P03356 POL_MLVAV 4.00E-19 GO:0015074; GO:0006310; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0075713; GO:0090305; GO:0006508; GO:0004523; GO:0046718 DNA integration; DNA recombination; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; establishment of integrated proviral latency; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; viral entry into host cell IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR002156; IPR000477; Pol polyprotein [Cleaved into: Protease (EC 3.4.23.-); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 3.1.26.4); Integrase (IN)] pol AKV murine leukemia virus (AKR (endogenous) murine leukemia virus) TR10567_c0_g1_i1 P18172 DHGL_DROPS 7.00E-12 GO:0006066; GO:0008812; GO:0005576; GO:0050660 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR10571_c0_g1_i1 P13363 ACT_PHYME 2.00E-09 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; Actin Phytophthora megasperma (Potato pink rot fungus) TR10576_c0_g1_i1 P20000 ALDH2_BOVIN 4.00E-31 GO:0004029; GO:0006068; GO:0005759 aldehyde dehydrogenase (NAD) activity; ethanol catabolic process; mitochondrial matrix IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. "Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI)" ALDH2 Bos taurus (Bovine) TR10576_c0_g2_i1 P46369 THCA_RHOER 2.00E-06 GO:0004029 aldehyde dehydrogenase (NAD) activity IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; EPTC-inducible aldehyde dehydrogenase (EC 1.2.1.3) thcA Rhodococcus erythropolis (Arthrobacter picolinophilus) TR10579_c0_g1_i1 Q29461 CEL2A_BOVIN 2.00E-13 GO:0005576; GO:0006508; GO:0004252 extracellular region; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Chymotrypsin-like elastase family member 2A (EC 3.4.21.71) (Elastase II) (Elastase-2) (Elastase-2A) CELA2A ELA2 ELA2A Bos taurus (Bovine) TR10581_c0_g1_i1 P33316 DUT_HUMAN 8.00E-21 GO:0006260; GO:0006226; GO:0004170; GO:0046080; GO:0005739; GO:0005654; GO:0006206; GO:0046134 Q6ZVK8 DNA replication; dUMP biosynthetic process; dUTP diphosphatase activity; dUTP metabolic process; mitochondrion; nucleoplasm; pyrimidine nucleobase metabolic process; pyrimidine nucleoside biosynthetic process IPR008180; IPR008181; Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)" DUT Homo sapiens (Human) TR10583_c0_g1_i1 P62335 PRS10_SPETR 2.00E-24 GO:0005524; GO:0005737; GO:0017111; GO:0005634; GO:0005886; GO:0022624; GO:0030163 ATP binding; cytoplasm; nucleoside-triphosphatase activity; nucleus; plasma membrane; proteasome accessory complex; protein catabolic process IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Conserved ATPase domain protein 44) (CADp44) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42) PSMC6 SUG2 Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) (Ictidomys tridecemlineatus) TR10586_c0_g1_i1 Q4KL94 NT1AA_XENLA 3.00E-77 GO:0018016; GO:0035572; GO:0035573; GO:0007059; GO:0005634; GO:0008276; GO:0007051 N-terminal peptidyl-proline dimethylation; N-terminal peptidyl-serine dimethylation; N-terminal peptidyl-serine trimethylation; chromosome segregation; nucleus; protein methyltransferase activity; spindle organization IPR008576; N-terminal Xaa-Pro-Lys N-methyltransferase 1-A (EC 2.1.1.244) (Alpha N-terminal protein methyltransferase 1A-A) (Methyltransferase-like protein 11A-A) (X-Pro-Lys N-terminal protein methyltransferase 1A-A) (NTM1A-A) ntmt1-a mettl11a-a MGC116538 Xenopus laevis (African clawed frog) TR1059_c0_g1_i1 P49630 RL36_DROME 3.00E-33 GO:0000228; GO:0005730; GO:0005840; GO:0003735; GO:0006412 nuclear chromosome; nucleolus; ribosome; structural constituent of ribosome; translation IPR000509; 60S ribosomal protein L36 (Protein minute(1)1B) RpL36 M(1)1B CG7622 Drosophila melanogaster (Fruit fly) TR10603_c1_g1_i1 B2RR83 YTDC2_MOUSE 3.00E-25 GO:0005524; GO:0008026; GO:0003676 ATP binding; ATP-dependent helicase activity; nucleic acid binding IPR002110; IPR020683; IPR011545; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; IPR001374; IPR007275; Probable ATP-dependent RNA helicase YTHDC2 (EC 3.6.4.13) Ythdc2 Mus musculus (Mouse) TR10608_c0_g1_i1 Q8Q0U0 Y045_METMA 9.00E-06 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR10609_c0_g2_i3 P13732 RL22_TRIGR 9.00E-36 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR002671; 60S ribosomal protein L22 (Development-specific protein 217) RPL22 Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla) TR10614_c0_g1_i1 P27216 ANX13_HUMAN 3.00E-24 GO:0005509; GO:0005544; GO:0030154; GO:0005886 calcium ion binding; calcium-dependent phospholipid binding; cell differentiation; plasma membrane IPR001464; IPR018502; IPR018252; IPR009166; Annexin A13 (Annexin XIII) (Annexin-13) (Intestine-specific annexin) (ISA) ANXA13 ANX13 Homo sapiens (Human) TR1062_c0_g1_i2 Q1HQF8 KTAP2_AEDAE 4.00E-41 GO:0005615; GO:0016021 extracellular space; integral to membrane IPR018614; Protein KRTCAP2 homolog AAEL007634 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR10620_c0_g1_i1 Q641Z1 LIN54_RAT 5.00E-06 GO:0003677; GO:0007049; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cell cycle; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR005172; IPR028307; Protein lin-54 homolog Lin54 Rattus norvegicus (Rat) TR10627_c1_g1_i1 Q9VJE5 CL190_DROME 1.00E-08 GO:0005794; GO:0003779; GO:0007349; GO:0045169; GO:0000776; GO:0005875; GO:0051010; GO:0007017; GO:0005876 Golgi apparatus; actin binding; cellularization; fusome; kinetochore; microtubule associated complex; microtubule plus-end binding; microtubule-based process; spindle microtubule IPR000938; Restin homolog (Cytoplasmic linker protein 190) (Microtubule-binding protein 190) (d-CLIP-190) CLIP-190 CG5020 Drosophila melanogaster (Fruit fly) TR10654_c1_g1_i1 Q0IH22 PPD1B_XENLA 1.00E-33 GO:0090136; GO:0016021; GO:0016328; GO:0007275; GO:0040017; GO:0001921; GO:0043088; GO:0032314; GO:0008360; GO:0005198; GO:0034446; GO:0005923; GO:0016192 epithelial cell-cell adhesion; integral to membrane; lateral plasma membrane; multicellular organismal development; positive regulation of locomotion; positive regulation of receptor recycling; regulation of Cdc42 GTPase activity; regulation of Rac GTPase activity; regulation of cell shape; structural molecule activity; substrate adhesion-dependent cell spreading; tight junction; vesicle-mediated transport IPR018490; IPR006916; Blood vessel epicardial substance-B (Popeye domain-containing protein 1-B) (Popeye protein 1-B) (Xpop-1-B) bves-b pop1-b popdc1-b Xenopus laevis (African clawed frog) TR10670_c3_g1_i1 P11369 POL2_MOUSE 2.00E-10 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR013544; IPR005135; IPR000477; Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element-1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] Pol Gm17492 Mus musculus (Mouse) TR10678_c0_g2_i1 Q7XJ98 KATAM_ARATH 2.00E-11 GO:0032580; GO:0010256; GO:0005768; GO:0042353; GO:0030173; GO:0006486; GO:0009863; GO:0005802; GO:0016757; GO:0009826; GO:0009969 "Golgi cisterna membrane; endomembrane system organization; endosome; fucose biosynthetic process; integral to Golgi membrane; protein glycosylation; salicylic acid mediated signaling pathway; trans-Golgi network; transferase activity, transferring glycosyl groups; unidimensional cell growth; xyloglucan biosynthetic process" IPR004263; Protein modification; protein glycosylation. Xyloglucan galactosyltransferase KATAMARI1 (EC 2.4.1.-) (Protein MURUS 3) KAM1 MUR3 At2g20370 F11A3.8 Arabidopsis thaliana (Mouse-ear cress) TR10683_c0_g1_i1 Q502K2 SAMH1_DANRE 7.00E-12 GO:0003723; GO:0051607; GO:0045087; GO:0008152; GO:0046872; GO:0005634; GO:0008081; GO:0045088 RNA binding; defense response to virus; innate immune response; metabolic process; metal ion binding; nucleus; phosphoric diester hydrolase activity; regulation of innate immune response IPR003607; IPR006674; IPR001660; IPR013761; IPR011510; Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) samhd1 Danio rerio (Zebrafish) (Brachydanio rerio) TR10683_c1_g1_i1 Q5ZJL9 SAMH1_CHICK 7.00E-13 GO:0003723; GO:0051607; GO:0045087; GO:0008152; GO:0046872; GO:0005634; GO:0008081; GO:0045088 RNA binding; defense response to virus; innate immune response; metabolic process; metal ion binding; nucleus; phosphoric diester hydrolase activity; regulation of innate immune response IPR003607; IPR006674; Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) SAMHD1 RCJMB04_17d8 Gallus gallus (Chicken) TR10686_c0_g1_i1 Q97UU4 Y2899_SULSO 7.00E-16 IPR002589; Uncharacterized protein SSO2899 SSO2899 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) TR10691_c2_g1_i1 Q8JHV9 BIR7A_XENLA 2.00E-06 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR10699_c0_g1_i1 Q3HNM7 INSC_MOUSE 1.00E-10 GO:0045177; GO:0005737; GO:0000132; GO:0060487; GO:0007399 apical part of cell; cytoplasm; establishment of mitotic spindle orientation; lung epithelial cell differentiation; nervous system development IPR011989; IPR016024; Protein inscuteable homolog (Minsc) Insc Mus musculus (Mouse) TR10705_c0_g1_i1 Q9H9B1 EHMT1_HUMAN 6.00E-09 GO:0006306; GO:0005694; GO:0009790; GO:0046976; GO:0046974; GO:0000122; GO:0045892; GO:0005634; GO:0018027; GO:0018026; GO:0008270 Q99549; Q04206; Q04207 "DNA methylation; chromosome; embryo development; histone methyltransferase activity (H3-K27 specific); histone methyltransferase activity (H3-K9 specific); negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; peptidyl-lysine dimethylation; peptidyl-lysine monomethylation; zinc ion binding" IPR002110; IPR020683; IPR007728; IPR003606; IPR001214; Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) EHMT1 EUHMTASE1 GLP KIAA1876 KMT1D Homo sapiens (Human) TR10715_c0_g2_i1 Q9JJN0 POLH_MOUSE 3.00E-17 GO:0006260; GO:0000731; GO:0003887; GO:0003684; GO:0046872; GO:0005634; GO:0006301; GO:0006290; GO:0010225 DNA replication; DNA synthesis involved in DNA repair; DNA-directed DNA polymerase activity; damaged DNA binding; metal ion binding; nucleus; postreplication repair; pyrimidine dimer repair; response to UV-C IPR017061; IPR017961; IPR001126; IPR017963; DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein homolog) Polh Rad30a Xpv Mus musculus (Mouse) TR10720_c0_g1_i1 Q86YT6 MIB1_HUMAN 8.00E-14 GO:0007219; GO:0001568; GO:0005813; GO:0031410; GO:0005829; GO:0001947; GO:0001701; GO:0045665; GO:0001841; GO:0031965; GO:0005886; GO:0045807; GO:0001756; GO:0004842; GO:0008270 Q9QYP6; Q9UHD2 Notch signaling pathway; blood vessel development; centrosome; cytoplasmic vesicle; cytosol; heart looping; in utero embryonic development; negative regulation of neuron differentiation; neural tube formation; nuclear membrane; plasma membrane; positive regulation of endocytosis; somitogenesis; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MIB1 (EC 6.3.2.-) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (Zinc finger ZZ type with ankyrin repeat domain protein 2) MIB1 DIP1 KIAA1323 ZZANK2 Homo sapiens (Human) TR10729_c0_g1_i1 B1A193 RASFA_XENLA 6.00E-09 GO:0005829; GO:0005815; GO:0007165; GO:0000922 cytosol; microtubule organizing center; signal transduction; spindle pole IPR000159; Ras association domain-containing protein 10 rassf10 Xenopus laevis (African clawed frog) TR1073_c0_g1_i1 Q05915 GCH1_MOUSE 3.00E-10 GO:0035998; GO:0005525; GO:0006184; GO:0003934; GO:0031410; GO:0005829; GO:0042416; GO:0050884; GO:0031965; GO:0051000; GO:0043234; GO:0051260; GO:0014916; GO:0034341; GO:0032496; GO:0048265; GO:0034612; GO:0006729; GO:0046654; GO:0008270 "7,8-dihydroneopterin 3'-triphosphate biosynthetic process; GTP binding; GTP catabolic process; GTP cyclohydrolase I activity; cytoplasmic vesicle; cytosol; dopamine biosynthetic process; neuromuscular process controlling posture; nuclear membrane; positive regulation of nitric-oxide synthase activity; protein complex; protein homooligomerization; regulation of lung blood pressure; response to interferon-gamma; response to lipopolysaccharide; response to pain; response to tumor necrosis factor; tetrahydrobiopterin biosynthetic process; tetrahydrofolate biosynthetic process; zinc ion binding" IPR001474; IPR018234; IPR020602; "Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1." GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I) Gch1 Gch Mus musculus (Mouse) TR10730_c0_g1_i1 Q02357 ANK1_MOUSE 2.00E-07 GO:0030863; GO:0048821; GO:0016020; GO:0015672; GO:0006779; GO:0016529; GO:0007165; GO:0014731 cortical cytoskeleton; erythrocyte development; membrane; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; sarcoplasmic reticulum; signal transduction; spectrin-associated cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) TR10748_c0_g1_i1 Q0WYX8 MDGA1_CHICK 9.00E-07 GO:0046658; GO:0001764 anchored to plasma membrane; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 MDGA1 Gallus gallus (Chicken) TR10750_c1_g1_i1 P56719 OX2R_RAT 3.00E-10 GO:0022410; GO:0007631; GO:0016021; GO:0007218; GO:0016499; GO:0017046; GO:0007200; GO:0005886 circadian sleep/wake cycle process; feeding behavior; integral to membrane; neuropeptide signaling pathway; orexin receptor activity; peptide hormone binding; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane IPR000276; IPR017452; IPR000204; IPR004060; Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Rattus norvegicus (Rat) TR10759_c1_g1_i1 Q9C0D6 FHDC1_HUMAN 1.00E-14 IPR015425; FH2 domain-containing protein 1 FHDC1 KIAA1727 Homo sapiens (Human) TR10761_c0_g1_i1 P17972 KCNAW_DROME 7.00E-11 GO:0005251; GO:0051260; GO:0030431; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; sleep; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR015572; IPR003131; IPR028325; Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) TR10769_c0_g1_i1 P50994 ANXA4_CANFA 1.00E-50 GO:0005509; GO:0005544 calcium ion binding; calcium-dependent phospholipid binding IPR001464; IPR018502; IPR018252; IPR002391; Annexin A4 (36 kDa zymogen granule membrane-associated protein) (ZAP36) (Annexin IV) (Annexin-4) (Lipocortin IV) ANXA4 ANX4 Canis familiaris (Dog) (Canis lupus familiaris) TR10770_c0_g1_i1 Q9BZP6 CHIA_HUMAN 3.00E-23 GO:0006915; GO:0030246; GO:0006037; GO:0008061; GO:0006032; GO:0004568; GO:0005737; GO:0007586; GO:0005615; GO:0006955; GO:0003796; GO:0000272; GO:0090197; GO:0002532; GO:0001101; GO:0009620 apoptotic process; carbohydrate binding; cell wall chitin metabolic process; chitin binding; chitin catabolic process; chitinase activity; cytoplasm; digestion; extracellular space; immune response; lysozyme activity; polysaccharide catabolic process; positive regulation of chemokine secretion; production of molecular mediator involved in inflammatory response; response to acid; response to fungus IPR002557; IPR011583; IPR001223; IPR001579; IPR013781; IPR017853; Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Lung-specific protein TSA1902) CHIA Homo sapiens (Human) TR10770_c0_g2_i1 Q91XA9 CHIA_MOUSE 2.00E-25 GO:0006915; GO:0008061; GO:0006032; GO:0004568; GO:0005737; GO:0005615; GO:0000272; GO:0090197; GO:0002532 apoptotic process; chitin binding; chitin catabolic process; chitinase activity; cytoplasm; extracellular space; polysaccharide catabolic process; positive regulation of chemokine secretion; production of molecular mediator involved in inflammatory response IPR002557; IPR011583; IPR001223; IPR001579; IPR013781; IPR017853; Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (YNL) Chia Mus musculus (Mouse) TR10772_c1_g1_i1 Q29116 TENA_PIG 6.00E-23 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (P230) (Tenascin-C) (TN-C) TNC HXB Sus scrofa (Pig) TR10774_c0_g1_i1 P51612 XPC_MOUSE 6.00E-25 GO:0071942; GO:0005737; GO:0003684; GO:0031573; GO:0006289; GO:0000715; GO:0010224; GO:0003697 "XPC complex; cytoplasm; damaged DNA binding; intra-S DNA damage checkpoint; nucleotide-excision repair; nucleotide-excision repair, DNA damage recognition; response to UV-B; single-stranded DNA binding" IPR004583; IPR018026; IPR018325; IPR018326; IPR018327; IPR018328; DNA repair protein complementing XP-C cells homolog (Xeroderma pigmentosum group C-complementing protein homolog) (p125) Xpc Mus musculus (Mouse) TR10774_c0_g2_i1 P14736 RAD4_YEAST 1.00E-08 GO:0005829; GO:0003684; GO:0006289; GO:0000111; GO:0043161 P32628 cytosol; damaged DNA binding; nucleotide-excision repair; nucleotide-excision repair factor 2 complex; proteasomal ubiquitin-dependent protein catabolic process IPR004583; IPR018325; IPR018326; IPR018327; IPR018328; DNA repair protein RAD4 RAD4 YER162C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR10782_c0_g1_i1 Q29S00 OSCP1_BOVIN 6.00E-103 GO:0009925; GO:0006810 basal plasma membrane; transport IPR019332; Protein OSCP1 OSCP1 Bos taurus (Bovine) TR10784_c3_g1_i1 Q96JQ0 PCD16_HUMAN 9.00E-11 GO:0005509; GO:0016339; GO:0007156; GO:0016021; GO:0016020; GO:0005886 calcium ion binding; calcium-dependent cell-cell adhesion; homophilic cell adhesion; integral to membrane; membrane; plasma membrane IPR002126; IPR015919; IPR020894; Protocadherin-16 (Cadherin-19) (Cadherin-25) (Fibroblast cadherin-1) (Protein dachsous homolog 1) DCHS1 CDH19 CDH25 FIB1 KIAA1773 PCDH16 Homo sapiens (Human) TR10792_c1_g1_i1 P05164 PERM_HUMAN 7.00E-22 GO:0003682; GO:0006952; GO:0050832; GO:0005615; GO:0020037; GO:0008201; GO:0042744; GO:0002149; GO:0034374; GO:0005764; GO:0046872; GO:0005739; GO:0043066; GO:0044130; GO:0005634; GO:0004601; GO:0019430; GO:0002679; GO:0001878; GO:0030141 chromatin binding; defense response; defense response to fungus; extracellular space; heme binding; heparin binding; hydrogen peroxide catabolic process; hypochlorous acid biosynthetic process; low-density lipoprotein particle remodeling; lysosome; metal ion binding; mitochondrion; negative regulation of apoptotic process; negative regulation of growth of symbiont in host; nucleus; peroxidase activity; removal of superoxide radicals; respiratory burst involved in defense response; response to yeast; secretory granule IPR010255; IPR002007; IPR019791; Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain] MPO Homo sapiens (Human) TR10795_c0_g1_i1 P31696 AGRIN_CHICK 7.00E-06 GO:0007213; GO:0030548; GO:0005605; GO:0005509; GO:0030154; GO:0030054; GO:0035374; GO:0002162; GO:0043395; GO:0008201; GO:0016021; GO:0043236; GO:0007275; GO:0005886; GO:0032321; GO:0051491; GO:0045887; GO:0045944; GO:0043113; GO:0033691; GO:0045202; GO:0030297 P05067; P02469 G-protein coupled acetylcholine receptor signaling pathway; acetylcholine receptor regulator activity; basal lamina; calcium ion binding; cell differentiation; cell junction; chondroitin sulfate binding; dystroglycan binding; heparan sulfate proteoglycan binding; heparin binding; integral to membrane; laminin binding; multicellular organismal development; plasma membrane; positive regulation of Rho GTPase activity; positive regulation of filopodium assembly; positive regulation of synaptic growth at neuromuscular junction; positive regulation of transcription from RNA polymerase II promoter; receptor clustering; sialic acid binding; synapse; transmembrane receptor protein tyrosine kinase activator activity IPR004850; IPR008985; IPR013320; IPR000742; IPR013032; IPR000152; IPR002049; IPR003645; IPR002350; IPR001791; IPR000082; IPR008993; Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)] AGRN AGRIN Gallus gallus (Chicken) TR10799_c0_g1_i1 Q92959 SO2A1_HUMAN 4.00E-25 GO:0005887; GO:0005319; GO:0015132; GO:0043252; GO:0055085 P62993 integral to plasma membrane; lipid transporter activity; prostaglandin transmembrane transporter activity; sodium-independent organic anion transport; transmembrane transport IPR002350; IPR020846; IPR016196; IPR004156; Solute carrier organic anion transporter family member 2A1 (Prostaglandin transporter) (PGT) (Solute carrier family 21 member 2) SLCO2A1 OATP2A1 SLC21A2 Homo sapiens (Human) TR10805_c0_g1_i1 P63033 RHES_RAT 8.00E-21 GO:0005525; GO:0003924; GO:0007626; GO:0031397; GO:0005886; GO:0051897; GO:0033235; GO:0043949; GO:0007264; GO:0001963 "GTP binding; GTPase activity; locomotory behavior; negative regulation of protein ubiquitination; plasma membrane; positive regulation of protein kinase B signaling cascade; positive regulation of protein sumoylation; regulation of cAMP-mediated signaling; small GTPase mediated signal transduction; synaptic transmission, dopaminergic" IPR027417; IPR005225; IPR001806; IPR020849; GTP-binding protein Rhes (Ras homolog enriched in striatum) (SE6C) Rasd2 Rattus norvegicus (Rat) TR10822_c0_g1_i1 A8MT65 ZN891_HUMAN 4.00E-18 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 891 ZNF891 Homo sapiens (Human) TR10837_c0_g1_i1 Q96NW4 ANR27_HUMAN 3.00E-06 GO:0005096; GO:0005769; GO:0045022; GO:0005085; GO:0005764; GO:0043547 Q13439; Q12840; P33175; Q9JHW5 GTPase activator activity; early endosome; early endosome to late endosome transport; guanyl-nucleotide exchange factor activity; lysosome; positive regulation of GTPase activity IPR002110; IPR020683; IPR003123; IPR013995; Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein) ANKRD27 PP12899 Homo sapiens (Human) TR10841_c1_g1_i1 P04323 POL3_DROME 4.00E-15 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR10842_c1_g1_i1 Q04741 EMX1_HUMAN 3.00E-28 GO:0003677; GO:0021796; GO:0005737; GO:0007275; GO:0030182; GO:0005634; GO:0009791; GO:0042493; GO:0043565; GO:0003700 DNA binding; cerebral cortex regionalization; cytoplasm; multicellular organismal development; neuron differentiation; nucleus; post-embryonic development; response to drug; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein EMX1 (Empty spiracles homolog 1) (Empty spiracles-like protein 1) EMX1 Homo sapiens (Human) TR10846_c0_g1_i1 P14381 YTX2_XENLA 4.00E-12 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR10854_c0_g1_i1 Q8WZ42 TITIN_HUMAN 2.00E-15 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR10854_c0_g1_i2 Q23551 UNC22_CAEEL 3.00E-15 GO:0031672; GO:0005524; GO:0046872; GO:0004674 A band; ATP binding; metal ion binding; protein serine/threonine kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans TR10858_c0_g1_i1 Q6GX86 CQ053_RAT 3.00E-07 IPR028045; Uncharacterized protein C17orf53 homolog Rattus norvegicus (Rat) TR1086_c0_g1_i1 O43156 TTI1_HUMAN 5.00E-08 GO:0031931; GO:0031932; GO:0005737; GO:0032006 Q13315; Q13535; Q9Y4R8 TORC1 complex; TORC2 complex; cytoplasm; regulation of TOR signaling cascade IPR011989; IPR016024; IPR016441; TELO2-interacting protein 1 homolog (Protein SMG10) TTI1 KIAA0406 SMG10 Homo sapiens (Human) TR10861_c0_g1_i1 A6NFI3 ZN316_HUMAN 4.00E-17 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 316 ZNF316 Homo sapiens (Human) TR10861_c0_g2_i1 O43829 ZF161_HUMAN 1.00E-23 GO:0003677; GO:0046872; GO:0000122; GO:0005634; GO:0006351 "DNA binding; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5) ZBTB14 ZFP161 ZNF478 Homo sapiens (Human) TR10866_c0_g2_i1 O34371 YTET_BACSU 3.00E-09 GO:0016491 oxidoreductase activity IPR016040; IPR000683; IPR004104; Putative oxidoreductase YteT (EC 1.-.-.-) yteT BSU30100 Bacillus subtilis (strain 168) TR10867_c2_g1_i1 P11369 POL2_MOUSE 2.00E-09 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR013544; IPR005135; IPR000477; Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element-1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] Pol Gm17492 Mus musculus (Mouse) TR10870_c0_g1_i1 P27765 AMID_PSECL 4.00E-21 GO:0004040; GO:0016884 "amidase activity; carbon-nitrogen ligase activity, with glutamine as amido-N-donor" IPR000120; IPR020556; IPR023631; Amidase (EC 3.5.1.4) Pseudomonas chlororaphis (Pseudomonas aureofaciens) TR10874_c1_g1_i1 P15364 AMAL_DROME 5.00E-10 GO:0031225; GO:0005886 anchored to membrane; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Protein amalgam Ama CG2198 Drosophila melanogaster (Fruit fly) TR10883_c1_g1_i1 P48451 CANB1_DROME 3.00E-09 GO:0005955; GO:0005509; GO:0008597; GO:0005516; GO:0007269; GO:0051533; GO:0006470; GO:0030431; GO:0008021; GO:0016192 calcineurin complex; calcium ion binding; calcium-dependent protein serine/threonine phosphatase regulator activity; calmodulin binding; neurotransmitter secretion; positive regulation of NFAT protein import into nucleus; protein dephosphorylation; sleep; synaptic vesicle; vesicle-mediated transport IPR011992; IPR018247; IPR002048; Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) CanB CANB1 CNB CNB1 CG4209 Drosophila melanogaster (Fruit fly) TR10883_c1_g1_i2 Q3KQ77 EFCB1_XENLA 6.00E-57 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; EF-hand calcium-binding domain-containing protein 1 efcab1 Xenopus laevis (African clawed frog) TR10885_c0_g1_i1 Q54JR2 ABCC3_DICDI 6.00E-33 GO:0005524; GO:0042626; GO:0031154; GO:0016021 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; culmination involved in sorocarp development; integral to membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; ABC transporter C family member 3 (ABC transporter ABCC.3) abcC3 DDB_G0287691 Dictyostelium discoideum (Slime mold) TR10886_c0_g1_i1 P27117 DCOR_BOVIN 2.00E-15 GO:0004586; GO:0033387 ornithine decarboxylase activity; putrescine biosynthetic process from ornithine IPR009006; IPR022643; IPR022657; IPR022644; IPR022653; IPR000183; IPR002433; Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1. Ornithine decarboxylase (ODC) (EC 4.1.1.17) ODC1 ODC Bos taurus (Bovine) TR10886_c1_g1_i1 P49725 DCOR_PANRE 1.00E-17 GO:0004586; GO:0033387 ornithine decarboxylase activity; putrescine biosynthetic process from ornithine IPR009006; IPR022643; IPR022644; IPR022653; IPR000183; IPR002433; Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1. Ornithine decarboxylase (ODC) (EC 4.1.1.17) ODC Panagrellus redivivus (Microworm) TR10896_c0_g1_i1 P22792 CPN2_HUMAN 5.00E-06 GO:0030234; GO:0005576; GO:0050821 enzyme regulator activity; extracellular region; protein stabilization IPR000483; IPR001611; IPR025875; IPR003591; IPR000372; Carboxypeptidase N subunit 2 (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N large subunit) (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N regulatory subunit) CPN2 ACBP Homo sapiens (Human) TR10903_c0_g1_i1 Q62839 GOGA2_RAT 1.00E-25 GO:0000137; GO:0032580; GO:0000139; GO:0005801; GO:0043025; GO:0043234; GO:0032403 O35254; O00506; Q9DB43 Golgi cis cisterna; Golgi cisterna membrane; Golgi membrane; cis-Golgi network; neuronal cell body; protein complex; protein complex binding IPR024858; Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) Golga2 Rattus norvegicus (Rat) TR10903_c0_g2_i1 Q08379 GOGA2_HUMAN 1.00E-20 GO:0032580; GO:0051645; GO:0000139; GO:0005801; GO:0000278; GO:0050772 Q99996; O00506 Golgi cisterna membrane; Golgi localization; Golgi membrane; cis-Golgi network; mitotic cell cycle; positive regulation of axonogenesis IPR024858; Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95) GOLGA2 Homo sapiens (Human) TR10905_c1_g1_i1 P15693 PPBI1_RAT 2.00E-27 GO:0004035; GO:0031225; GO:0009897; GO:0016021; GO:0000287; GO:0008270 alkaline phosphatase activity; anchored to membrane; external side of plasma membrane; integral to membrane; magnesium ion binding; zinc ion binding IPR017849; IPR001952; IPR018299; IPR017850; Intestinal-type alkaline phosphatase 1 (IAP-1) (Intestinal alkaline phosphatase 1) (EC 3.1.3.1) (Intestinal alkaline phosphatase I) (IAP-I) Alpi Rattus norvegicus (Rat) TR10906_c0_g2_i1 Q6DFV8 VWDE_MOUSE 6.00E-09 GO:0005576 extracellular region IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) TR10907_c0_g2_i1 Q9HFY6 CALM_BLAEM 7.00E-54 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) CMD1 Blastocladiella emersonii (Aquatic fungus) TR10910_c0_g1_i1 Q80ZF8 BAI3_MOUSE 6.00E-07 GO:0004930; GO:0016021; GO:0016525; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; negative regulation of angiogenesis; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR008077; IPR001879; IPR000832; IPR017983; IPR000203; IPR000884; Brain-specific angiogenesis inhibitor 3 Bai3 Mus musculus (Mouse) TR10911_c2_g1_i1 P11528 GCY_ARBPU 2.00E-20 GO:0005524; GO:0005525; GO:0004383; GO:0016021; GO:0004672 ATP binding; GTP binding; guanylate cyclase activity; integral to membrane; protein kinase activity IPR001828; IPR011009; IPR028082; IPR000719; IPR001245; Resact receptor (EC 4.6.1.2) (Guanylate cyclase) Arbacia punctulata (Punctuate sea urchin) TR10912_c0_g1_i1 Q07078 HSP83_ORYSJ 3.00E-52 GO:0005524; GO:0005737; GO:0006457; GO:0006950 ATP binding; cytoplasm; protein folding; response to stress IPR003594; IPR019805; IPR001404; IPR020575; IPR020568; Heat shock protein 81-3 (HSP81-3) (Gravity-specific protein GSC 381) HSP81-3 Os09g0482300 Os09g0482400 LOC_Os09g30438 P0463D04.35 Oryza sativa subsp. japonica (Rice) TR10922_c1_g1_i1 P42906 AGAA_ECOLI 2.00E-06 GO:0005975; GO:0016787 carbohydrate metabolic process; hydrolase activity IPR006680; Putative N-acetylgalactosamine-6-phosphate deacetylase (EC 3.5.1.-) agaA b3135 JW5527 Escherichia coli (strain K12) TR10922_c2_g1_i1 Q9Y303 NAGA_HUMAN 3.00E-93 GO:0006044; GO:0008448; GO:0019262; GO:0005975; GO:0046872 N-acetylglucosamine metabolic process; N-acetylglucosamine-6-phosphate deacetylase activity; N-acetylneuraminate catabolic process; carbohydrate metabolic process; metal ion binding IPR003764; IPR011059; Amino-sugar metabolism; N-acetylneuraminate degradation. Putative N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) (Amidohydrolase domain-containing protein 2) (GlcNAc 6-P deacetylase) AMDHD2 CGI-14 Homo sapiens (Human) TR10934_c1_g1_i1 O28821 THSB_ARCFU 3.00E-06 GO:0005524; GO:0006457 ATP binding; protein folding IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; IPR012714; Thermosome subunit beta (Chaperonin subunit beta) (Thermosome subunit 2) thsB AF_1451 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) TR10934_c1_g1_i2 Q5ZJK8 TCPH_CHICK 3.00E-37 GO:0005524; GO:0007339; GO:0005832; GO:0005874; GO:0005739; GO:0006457; GO:0002199 ATP binding; binding of sperm to zona pellucida; chaperonin-containing T-complex; microtubule; mitochondrion; protein folding; zona pellucida receptor complex IPR012720; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) CCT7 RCJMB04_17g3 Gallus gallus (Chicken) TR10935_c0_g1_i1 P62311 LSM3_MOUSE 5.00E-11 GO:0003723; GO:0008380; GO:0071013; GO:0006397 RNA binding; RNA splicing; catalytic step 2 spliceosome; mRNA processing IPR010920; IPR001163; IPR006649; U6 snRNA-associated Sm-like protein LSm3 Lsm3 Mus musculus (Mouse) TR10946_c0_g1_i1 Q19981 TAG53_CAEEL 1.00E-17 GO:0016021; GO:0007275; GO:0004872 integral to membrane; multicellular organismal development; receptor activity IPR000859; IPR000742; IPR013032; IPR002049; IPR015916; IPR015915; IPR006652; IPR016201; IPR002165; Putative protein tag-53 tag-53 F33C8.1 Caenorhabditis elegans TR10951_c2_g1_i1 B2LT64 TLR2_GIRCA 1.00E-16 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Giraffa camelopardalis (Giraffe) TR10970_c0_g1_i1 O96952 THIO_GEOCY 1.00E-29 GO:0045454; GO:0005737; GO:0006662; GO:0015035 cell redox homeostasis; cytoplasm; glycerol ether metabolic process; protein disulfide oxidoreductase activity IPR005746; IPR012336; IPR017937; IPR013766; Thioredoxin (Trx) THIO Geodia cydonium (Sponge) TR10972_c0_g1_i1 Q8VDW0 DX39A_MOUSE 9.00E-51 GO:0005524; GO:0008026; GO:0005737; GO:0006406; GO:0000398; GO:0003676; GO:0005634 "ATP binding; ATP-dependent helicase activity; cytoplasm; mRNA export from nucleus; mRNA splicing, via spliceosome; nucleic acid binding; nucleus" IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) Ddx39a Ddx39 Mus musculus (Mouse) TR10985_c0_g1_i1 Q09575 YRD6_CAEEL 7.00E-23 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR10992_c0_g1_i1 Q9UKK3 PARP4_HUMAN 1.00E-12 GO:0003677; GO:0006281; GO:0003950; GO:0008219; GO:0005737; GO:0019899; GO:0006954; GO:0005634; GO:0006471; GO:0042493; GO:0030529; GO:0005876; GO:0006810 Q9Q2G4 DNA binding; DNA repair; NAD+ ADP-ribosyltransferase activity; cell death; cytoplasm; enzyme binding; inflammatory response; nucleus; protein ADP-ribosylation; response to drug; ribonucleoprotein complex; spindle microtubule; transport IPR001357; IPR012317; IPR004102; IPR013694; IPR002035; Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) TR11_c0_g1_i1 Q16674 MIA_HUMAN 3.00E-11 GO:0008283; GO:0005615 cell proliferation; extracellular space IPR011511; IPR001452; Melanoma-derived growth regulatory protein (Melanoma inhibitory activity protein) MIA Homo sapiens (Human) TR11002_c0_g1_i1 A2ASS6 TITIN_MOUSE 2.00E-13 GO:0005524; GO:0031430; GO:0030018; GO:0007512; GO:0055003; GO:0043056; GO:0003007; GO:0001701; GO:0046872; GO:0006936; GO:0005859; GO:0005634; GO:0018108; GO:0004674; GO:0004713; GO:1901897; GO:0045214; GO:0001756; GO:0005200 ATP binding; M band; Z disc; adult heart development; cardiac myofibril assembly; forward locomotion; heart morphogenesis; in utero embryonic development; metal ion binding; muscle contraction; muscle myosin complex; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of relaxation of cardiac muscle; sarcomere organization; somitogenesis; structural constituent of cytoskeleton IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) TR11004_c0_g1_i1 Q8WWF8 CAPSL_HUMAN 4.00E-06 GO:0005509; GO:0005737 calcium ion binding; cytoplasm IPR011992; IPR018247; IPR002048; IPR001125; Calcyphosin-like protein CAPSL Homo sapiens (Human) TR11004_c0_g2_i1 P02594 CALM_ELEEL 1.00E-49 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) calm Electrophorus electricus (Electric eel) TR11005_c0_g1_i1 Q8N4T0 CBPA6_HUMAN 2.00E-06 GO:0004181; GO:0005578; GO:0006508; GO:0008270 metallocarboxypeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000834; IPR003146; IPR009020; Carboxypeptidase A6 (EC 3.4.17.1) (Carboxypeptidase B) CPA6 CPAH Homo sapiens (Human) TR11009_c0_g1_i1 Q24157 BRN_DROME 4.00E-23 GO:0000139; GO:0005795; GO:0007219; GO:0046981; GO:0007298; GO:0005576; GO:0047915; GO:0007293; GO:0006688; GO:0008314; GO:0016021; GO:0042248; GO:0001744; GO:0007299; GO:0006486 "Golgi membrane; Golgi stack; Notch signaling pathway; beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity; border follicle cell migration; extracellular region; ganglioside galactosyltransferase activity; germarium-derived egg chamber formation; glycosphingolipid biosynthetic process; gurken receptor signaling pathway; integral to membrane; maintenance of polarity of follicular epithelium; optic lobe placode formation; ovarian follicle cell-cell adhesion; protein glycosylation" IPR002659; "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) TR11022_c0_g1_i1 Q01458 DIAC_BOVIN 1.00E-06 GO:0005975; GO:0004553; GO:0005764 "carbohydrate metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; lysosome" IPR001579; IPR017853; Di-N-acetylchitobiase (EC 3.2.1.-) (Fragment) CTBS CTB Bos taurus (Bovine) TR11023_c0_g1_i1 Q64319 SLC31_RAT 5.00E-11 GO:0006865; GO:0005975; GO:0003824; GO:0043169; GO:0005887; GO:0046982; GO:0005774 amino acid transport; carbohydrate metabolic process; catalytic activity; cation binding; integral to plasma membrane; protein heterodimerization activity; vacuolar membrane IPR015902; IPR006047; IPR006589; IPR013781; IPR017853; "Neutral and basic amino acid transport protein rBAT (B(0,+)-type amino acid transport protein) (NAA-TR) (D2) (Solute carrier family 3 member 1)" Slc3a1 Nbat Rattus norvegicus (Rat) TR11023_c0_g2_i1 Q7YQK3 4F2_RABIT 1.00E-10 GO:0016324; GO:0005975; GO:0003824; GO:0043169; GO:0016021; GO:0060356; GO:0042470; GO:0015175; GO:0015827 apical plasma membrane; carbohydrate metabolic process; catalytic activity; cation binding; integral to membrane; leucine import; melanosome; neutral amino acid transmembrane transporter activity; tryptophan transport IPR015902; IPR013780; IPR006047; IPR013781; IPR017853; 4F2 cell-surface antigen heavy chain (4F2hc) (Solute carrier family 3 member 2) (CD antigen CD98) SLC3A2 Oryctolagus cuniculus (Rabbit) TR11024_c0_g1_i1 Q9ESL4 MLTK_MOUSE 4.00E-80 GO:0005524; GO:0004709; GO:0000075; GO:0005737; GO:0007010; GO:0000287; GO:0005634; GO:0043065 ATP binding; MAP kinase kinase kinase activity; cell cycle checkpoint; cytoplasm; cytoskeleton organization; magnesium ion binding; nucleus; positive regulation of apoptotic process IPR011009; IPR000719; IPR001660; IPR013761; IPR021129; IPR001245; IPR008271; Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (Leucine zipper- and sterile alpha motif kinase ZAK) (MLK-like mitogen-activated protein triple kinase) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) Mltk Mus musculus (Mouse) TR11029_c0_g1_i1 Q6GPW2 SMO2B_XENLA 5.00E-39 GO:0005634; GO:0016925 nucleus; protein sumoylation IPR022617; IPR027218; IPR000626; Small ubiquitin-related modifier 2-B (SUMO-2-B) sumo2-b Xenopus laevis (African clawed frog) TR11031_c0_g1_i1 P39057 DYHC_ANTCR 9.00E-32 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein beta chain, ciliary" Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR11033_c0_g1_i1 Q6DDL7 UN93A_XENLA 7.00E-22 GO:0016021 integral to membrane IPR010291; IPR016196; Protein unc-93 homolog A (Unc-93A) unc93a Xenopus laevis (African clawed frog) TR11036_c2_g1_i1 P91621 SIF1_DROME 1.00E-26 GO:0030676; GO:0030054; GO:0035556; GO:0005543; GO:0051491; GO:0005057; GO:0032314; GO:0050770; GO:0050803; GO:0045202 Rac guanyl-nucleotide exchange factor activity; cell junction; intracellular signal transduction; phospholipid binding; positive regulation of filopodium assembly; receptor signaling protein activity; regulation of Rac GTPase activity; regulation of axonogenesis; regulation of synapse structure and activity; synapse IPR000219; IPR001331; IPR001478; IPR011993; IPR001849; IPR003116; IPR000697; "Protein still life, isoform SIF type 1" sif CG34418 Drosophila melanogaster (Fruit fly) TR11038_c2_g1_i1 Q5U2Z3 NP1L4_RAT 1.00E-17 GO:0006334; GO:0005634 nucleosome assembly; nucleus IPR002164; Nucleosome assembly protein 1-like 4 Nap1l4 Rattus norvegicus (Rat) TR11041_c0_g1_i1 Q9W2N0 CAPZA_DROME 7.00E-31 GO:0008290; GO:0071203; GO:0007015; GO:0016324; GO:0051016; GO:0000902; GO:0005869; GO:0007294; GO:0007018; GO:0051490; GO:0006909; GO:0010591; GO:0035220 F-actin capping protein complex; WASH complex; actin filament organization; apical plasma membrane; barbed-end actin filament capping; cell morphogenesis; dynactin complex; germarium-derived oocyte fate determination; microtubule-based movement; negative regulation of filopodium assembly; phagocytosis; regulation of lamellipodium assembly; wing disc development IPR002189; IPR017865; F-actin-capping protein subunit alpha cpa CG10540 Drosophila melanogaster (Fruit fly) TR11041_c1_g1_i1 P25229 CAZA1_XENLA 7.00E-17 GO:0008290; GO:0071203; GO:0030036; GO:0005634 F-actin capping protein complex; WASH complex; actin cytoskeleton organization; nucleus IPR002189; IPR017865; F-actin-capping protein subunit alpha-1 (Actin-binding protein chain A) (ABP-A) (Fragment) capza1 capza Xenopus laevis (African clawed frog) TR11043_c0_g1_i1 P59034 LRRC3_MOUSE 1.00E-15 GO:0016021 integral to membrane IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing protein 3 Lrrc3 Mus musculus (Mouse) TR11043_c0_g2_i1 O75325 LRRN2_HUMAN 2.00E-12 GO:0007155; GO:0016021; GO:0004872; GO:0007165 cell adhesion; integral to membrane; receptor activity; signal transduction IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeat neuronal protein 2 (Glioma amplified on chromosome 1 protein) (Leucine-rich repeat neuronal protein 5) LRRN2 GAC1 LRRN5 UNQ256/PRO293 Homo sapiens (Human) TR11062_c1_g1_i1 Q1RK13 Y220_RICBR 2.00E-21 IPR002110; IPR020683; Putative ankyrin repeat protein RBE_0220 RBE_0220 Rickettsia bellii (strain RML369-C) TR11063_c4_g1_i1 P12370 KAPC_DROME 2.00E-26 GO:0005524; GO:0007615; GO:0007448; GO:0048149; GO:0004691; GO:0005952; GO:0019933; GO:0048749; GO:0007480; GO:0007476; GO:0045475; GO:0045879; GO:0008355; GO:0007314; GO:0008103; GO:0005886; GO:0007228; GO:0008359; GO:0045187; GO:0007317; GO:0050804; GO:0040040 Q9VT65; Q03720 "ATP binding; anesthesia-resistant memory; anterior/posterior pattern specification, imaginal disc; behavioral response to ethanol; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase complex; cAMP-mediated signaling; compound eye development; imaginal disc-derived leg morphogenesis; imaginal disc-derived wing morphogenesis; locomotor rhythm; negative regulation of smoothened signaling pathway; olfactory learning; oocyte anterior/posterior axis specification; oocyte microtubule cytoskeleton polarization; plasma membrane; positive regulation of hh target transcription factor activity; regulation of bicoid mRNA localization; regulation of circadian sleep/wake cycle, sleep; regulation of pole plasm oskar mRNA localization; regulation of synaptic transmission; thermosensory behavior" IPR000961; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; cAMP-dependent protein kinase catalytic subunit (PKA C) (EC 2.7.11.11) Pka-C1 CdkA DC0 CG4379 Drosophila melanogaster (Fruit fly) TR11068_c0_g1_i1 P53355 DAPK1_HUMAN 7.00E-13 GO:0005524; GO:0015629; GO:0097190; GO:0005516; GO:0004683; GO:0071346; GO:0005737; GO:0007243; GO:0043066; GO:0017148; GO:0043065; GO:0046777; GO:2000310; GO:0010506 Itself; Q14457; Q9Y2M5; Q38SD2; Q5S007; P27361; O75340; P14618; P14618-1 ATP binding; actin cytoskeleton; apoptotic signaling pathway; calmodulin binding; calmodulin-dependent protein kinase activity; cellular response to interferon-gamma; cytoplasm; intracellular protein kinase cascade; negative regulation of apoptotic process; negative regulation of translation; positive regulation of apoptotic process; protein autophosphorylation; regulation of N-methyl-D-aspartate selective glutamate receptor activity; regulation of autophagy IPR002110; IPR020683; IPR011029; IPR000488; IPR011009; IPR020675; IPR027417; IPR000719; IPR017441; IPR002290; IPR008271; Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) DAPK1 DAPK Homo sapiens (Human) TR11068_c1_g1_i1 Q924X7 STK33_MOUSE 2.00E-43 GO:0005524; GO:0048471; GO:0046777; GO:0004674 ATP binding; perinuclear region of cytoplasm; protein autophosphorylation; protein serine/threonine kinase activity IPR020636; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase 33 (EC 2.7.11.1) Stk33 Mus musculus (Mouse) TR11069_c1_g1_i1 Q8BV79 TRNK1_MOUSE 5.00E-07 GO:0005524; GO:0016787 ATP binding; hydrolase activity IPR002110; IPR020683; IPR014017; IPR027417; IPR013026; IPR011990; TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1) Trank1 Gm187 Kiaa0342 Lba1 Mus musculus (Mouse) TR11077_c0_g1_i1 Q9CZJ2 HS12B_MOUSE 5.00E-09 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR11084_c0_g1_i1 Q9VI10 SMD2_DROME 2.00E-42 GO:0071013; GO:0000398; GO:0007067; GO:0007052; GO:0022008; GO:0071011; GO:0030532 "catalytic step 2 spliceosome; mRNA splicing, via spliceosome; mitosis; mitotic spindle organization; neurogenesis; precatalytic spliceosome; small nuclear ribonucleoprotein complex" IPR010920; IPR001163; IPR006649; IPR027248; Probable small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2) SmD2 snRNP2 CG1249 Drosophila melanogaster (Fruit fly) TR11104_c2_g1_i1 P08154 EGR1_RAT 8.00E-39 GO:0030509; GO:0001077; GO:0000979; GO:0030217; GO:0071236; GO:0071320; GO:0035690; GO:0071372; GO:0071480; GO:0071363; GO:0071504; GO:0071455; GO:0071456; GO:0032869; GO:0071317; GO:0071260; GO:0071506; GO:0071383; GO:0007623; GO:0005737; GO:0003690; GO:0072110; GO:0070498; GO:0007611; GO:0060291; GO:0046872; GO:0043066; GO:0090090; GO:0000122; GO:0005634; GO:0048709; GO:0072303; GO:0043525; GO:0048169; GO:0033233; GO:0001975; GO:0034465; GO:0042220; GO:0051602; GO:0045471; GO:0009749; GO:0071873; GO:0031667; GO:0035914 BMP signaling pathway; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II core promoter sequence-specific DNA binding; T cell differentiation; cellular response to antibiotic; cellular response to cAMP; cellular response to drug; cellular response to follicle-stimulating hormone stimulus; cellular response to gamma radiation; cellular response to growth factor stimulus; cellular response to heparin; cellular response to hyperoxia; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to isoquinoline alkaloid; cellular response to mechanical stimulus; cellular response to mycophenolic acid; cellular response to steroid hormone stimulus; circadian rhythm; cytoplasm; double-stranded DNA binding; glomerular mesangial cell proliferation; interleukin-1-mediated signaling pathway; learning or memory; long-term synaptic potentiation; metal ion binding; negative regulation of apoptotic process; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; oligodendrocyte differentiation; positive regulation of glomerular metanephric mesangial cell proliferation; positive regulation of neuron apoptotic process; regulation of long-term neuronal synaptic plasticity; regulation of protein sumoylation; response to amphetamine; response to carbon monoxide; response to cocaine; response to electrical stimulus; response to ethanol; response to glucose stimulus; response to norepinephrine stimulus; response to nutrient levels; skeletal muscle cell differentiation IPR021839; IPR021849; IPR007087; IPR015880; IPR013087; Early growth response protein 1 (EGR-1) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor Zif268) (Zinc finger protein Krox-24) Egr1 Rattus norvegicus (Rat) TR11105_c0_g1_i1 O78682 COX2_CARAU 2.00E-85 GO:0005507; GO:0004129; GO:0022900; GO:0016021; GO:0005743; GO:0045277 copper ion binding; cytochrome-c oxidase activity; electron transport chain; integral to membrane; mitochondrial inner membrane; respiratory chain complex IV IPR001505; IPR008972; IPR014222; IPR002429; IPR011759; Cytochrome c oxidase subunit 2 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide II) mt-co2 coii coxii mtco2 Carassius auratus (Goldfish) TR11109_c0_g1_i1 Q4R4J0 GDIR1_MACFA 4.00E-11 GO:0005096; GO:0005094; GO:0005737; GO:0043547 GTPase activator activity; Rho GDP-dissociation inhibitor activity; cytoplasm; positive regulation of GTPase activity IPR014756; IPR000406; IPR024792; Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) ARHGDIA QtrA-11619 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR1111_c0_g1_i1 Q62425 NDUA4_MOUSE 7.00E-14 GO:0004129; GO:0005751 cytochrome-c oxidase activity; mitochondrial respiratory chain complex IV IPR010530; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 (Complex I-MLRQ) (CI-MLRQ) (NADH-ubiquinone oxidoreductase MLRQ subunit) Ndufa4 Mus musculus (Mouse) TR11117_c0_g1_i1 Q9WU00 NRF1_MOUSE 5.00E-12 GO:0003677; GO:0007005; GO:0005634; GO:0003700; GO:0005667; GO:0006351 "DNA binding; mitochondrion organization; nucleus; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent" IPR019526; IPR019525; Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal) Nrf1 Mus musculus (Mouse) TR11119_c0_g1_i1 B2LU20 SFXN1_SHEEP 9.00E-52 GO:0008324; GO:0016021; GO:0055072; GO:0031966 cation transmembrane transporter activity; integral to membrane; iron ion homeostasis; mitochondrial membrane IPR004686; Sideroflexin-1 SFXN1 Ovis aries (Sheep) TR11120_c0_g1_i1 Q99N95 RM03_MOUSE 7.00E-44 GO:0005762; GO:0003735; GO:0006412 mitochondrial large ribosomal subunit; structural constituent of ribosome; translation IPR000597; IPR019927; IPR019926; IPR009000; "39S ribosomal protein L3, mitochondrial (L3mt) (MRP-L3)" Mrpl3 Mus musculus (Mouse) TR11120_c0_g1_i2 Q3ZBX6 RM03_BOVIN 5.00E-70 GO:0005762; GO:0003735; GO:0006412 mitochondrial large ribosomal subunit; structural constituent of ribosome; translation IPR000597; IPR019927; IPR019926; IPR009000; "39S ribosomal protein L3, mitochondrial (L3mt) (MRP-L3)" MRPL3 Bos taurus (Bovine) TR11121_c0_g3_i1 O70247 SC5A6_RAT 6.00E-17 GO:0015878; GO:0031526; GO:0016021; GO:0015887; GO:0008523; GO:0012506 biotin transport; brush border membrane; integral to membrane; pantothenate transmembrane transport; sodium-dependent multivitamin transmembrane transporter activity; vesicle membrane IPR001734; IPR018212; IPR019900; Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (Solute carrier family 5 member 6) Slc5a6 Smvt Rattus norvegicus (Rat) TR11125_c0_g1_i1 Q8TE60 ATS18_HUMAN 1.00E-28 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAM-TS 18) (ADAM-TS18) (ADAMTS-18) (EC 3.4.24.-) ADAMTS18 ADAMTS21 Homo sapiens (Human) TR11125_c1_g1_i1 Q8N6G6 ATL1_HUMAN 1.00E-10 GO:0008237; GO:0005578; GO:0008270 metallopeptidase activity; proteinaceous extracellular matrix; zinc ion binding IPR007110; IPR013783; IPR013098; IPR003598; IPR013273; IPR010909; IPR000884; ADAMTS-like protein 1 (ADAMTSL-1) (Punctin-1) ADAMTSL1 ADAMTSR1 C9orf94 UNQ528/PRO1071 Homo sapiens (Human) TR11128_c0_g1_i1 P50101 UBP15_YEAST 1.00E-11 GO:0005777; GO:0016579; GO:0004221; GO:0006511; GO:0004843 peroxisome; protein deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR002083; IPR018200; IPR001394; IPR008974; IPR024729; Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) UBP15 YMR304W YM9952.06 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR11128_c1_g1_i1 Q70CQ2 UBP34_HUMAN 1.00E-83 GO:0016055; GO:0004197; GO:0090263; GO:0071108; GO:0004221; GO:0006511; GO:0004843 Wnt receptor signaling pathway; cysteine-type endopeptidase activity; positive regulation of canonical Wnt receptor signaling pathway; protein K48-linked deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR016024; IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) USP34 KIAA0570 KIAA0729 Homo sapiens (Human) TR11131_c2_g1_i1 Q8N2E2 VWDE_HUMAN 2.00E-15 GO:0005576 extracellular region IPR000742; IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) TR11135_c0_g1_i1 Q63184 E2AK2_RAT 7.00E-19 GO:0005524; GO:0003723; GO:0000186; GO:0051607; GO:0045087; GO:0033689; GO:0017148; GO:0045071; GO:0004715; GO:0005634; GO:0018108; GO:0048471; GO:0051092; GO:1901224; GO:0043065; GO:0032722; GO:0032874; GO:0046777; GO:0004672; GO:0004674; GO:1900225; GO:1901532; GO:1902036; GO:1902033; GO:0043330; GO:0035455; GO:0032496; GO:0009612; GO:0009636; GO:0009615; GO:0033197; GO:0006351 "ATP binding; RNA binding; activation of MAPKK activity; defense response to virus; innate immune response; negative regulation of osteoblast proliferation; negative regulation of translation; negative regulation of viral genome replication; non-membrane spanning protein tyrosine kinase activity; nucleus; peptidyl-tyrosine phosphorylation; perinuclear region of cytoplasm; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB cascade; positive regulation of apoptotic process; positive regulation of chemokine production; positive regulation of stress-activated MAPK cascade; protein autophosphorylation; protein kinase activity; protein serine/threonine kinase activity; regulation of NLRP3 inflammasome complex assembly; regulation of hematopoietic progenitor cell differentiation; regulation of hematopoietic stem cell differentiation; regulation of hematopoietic stem cell proliferation; response to exogenous dsRNA; response to interferon-alpha; response to lipopolysaccharide; response to mechanical stimulus; response to toxic substance; response to virus; response to vitamin E; transcription, DNA-dependent" IPR014720; IPR011009; IPR000719; IPR017441; IPR008271; "Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2)" Eif2ak2 Prkr Rattus norvegicus (Rat) TR11149_c0_g1_i1 Q29RU2 OIT3_BOVIN 8.00E-12 GO:0005509; GO:0005635 calcium ion binding; nuclear envelope IPR000742; IPR000152; IPR018097; IPR009030; IPR001507; Oncoprotein-induced transcript 3 protein OIT3 Bos taurus (Bovine) TR11155_c1_g1_i1 Q9MYP6 DHB14_BOVIN 3.00E-67 GO:0005813; GO:0005829; GO:0004303; GO:0006706; GO:0047045 centrosome; cytosol; estradiol 17-beta-dehydrogenase activity; steroid catabolic process; testosterone 17-beta-dehydrogenase (NADP+) activity IPR002198; IPR002347; IPR016040; IPR020904; 17-beta-hydroxysteroid dehydrogenase 14 (17-beta-HSD 14) (EC 1.1.1.-) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) HSD17B14 DHRS10 SDR3 Bos taurus (Bovine) TR11155_c1_g1_i2 O32185 YUSS_BACSU 1.00E-07 GO:0055114; GO:0016491 oxidation-reduction process; oxidoreductase activity IPR002198; IPR002347; IPR016040; Short-chain dehydrogenase/reductase homolog YusS yusS BSU32910 Bacillus subtilis (strain 168) TR11156_c2_g1_i1 Q7ZU99 TERA_DANRE 3.00E-39 GO:0005524; GO:0030433; GO:0007049; GO:0005829; GO:0006302; GO:0009790; GO:0008289; GO:0017111; GO:0005634; GO:0018279; GO:0016567; GO:2000058; GO:0035861; GO:0019985; GO:0006810 ATP binding; ER-associated protein catabolic process; cell cycle; cytosol; double-strand break repair; embryo development; lipid binding; nucleoside-triphosphatase activity; nucleus; protein N-linked glycosylation via asparagine; protein ubiquitination; regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; site of double-strand break; translesion synthesis; transport IPR003593; IPR005938; IPR009010; IPR003959; IPR003960; IPR004201; IPR003338; IPR027417; IPR015415; Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (Protein CDC48) (Valosin-containing protein) (VCP) vcp cdc48 si:ch211-113n10.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR11157_c0_g2_i1 P10978 POLX_TOBAC 5.00E-08 GO:0015074; GO:0003964; GO:0004190; GO:0004519; GO:0003676; GO:0090305; GO:0006508; GO:0008270 DNA integration; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis; proteolysis; zinc ion binding IPR025724; IPR001584; IPR018061; IPR012337; IPR013103; IPR001878; Retrovirus-related Pol polyprotein from transposon TNT 1-94 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] Nicotiana tabacum (Common tobacco) TR11161_c0_g1_i1 P48066 S6A11_HUMAN 5.00E-20 GO:0007420; GO:0042995; GO:0005737; GO:0005332; GO:0016021; GO:0005887; GO:0042165; GO:0007269; GO:0005328; GO:0005886; GO:0042493; GO:0055085 brain development; cell projection; cytoplasm; gamma-aminobutyric acid:sodium symporter activity; integral to membrane; integral to plasma membrane; neurotransmitter binding; neurotransmitter secretion; neurotransmitter:sodium symporter activity; plasma membrane; response to drug; transmembrane transport IPR000175; IPR002982; Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11) SLC6A11 GABT3 GAT3 Homo sapiens (Human) TR11168_c0_g1_i2 P14618 KPYM_HUMAN 1.00E-146 GO:0005524; GO:0005929; GO:0005829; GO:0070062; GO:0006096; GO:0000287; GO:0005739; GO:0005634; GO:0005886; GO:0030955; GO:0012501; GO:0004743; GO:0044281 Q9WMX2; P49407; P32121; P53355; Q9H6Z9; Q16665; P04049 ATP binding; cilium; cytosol; extracellular vesicular exosome; glycolysis; magnesium ion binding; mitochondrion; nucleus; plasma membrane; potassium ion binding; programmed cell death; pyruvate kinase activity; small molecule metabolic process IPR001697; IPR015813; IPR011037; IPR015794; IPR018209; IPR015793; IPR015795; IPR015806; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (p58) PKM OIP3 PK2 PK3 PKM2 Homo sapiens (Human) TR11183_c1_g1_i1 Q9XT77 SC5A6_RABIT 8.00E-06 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR001734; IPR018212; IPR019900; Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (Solute carrier family 5 member 6) SLC5A6 SMVT Oryctolagus cuniculus (Rabbit) TR11193_c0_g1_i1 Q8BRH0 TMTC3_MOUSE 2.00E-20 GO:0060447; GO:0016021; GO:0048286; GO:0048747; GO:0009791; GO:0010468 bud outgrowth involved in lung branching; integral to membrane; lung alveolus development; muscle fiber development; post-embryonic development; regulation of gene expression IPR013618; IPR013026; IPR011990; IPR019734; Transmembrane and TPR repeat-containing protein 3 Tmtc3 Mus musculus (Mouse) TR11209_c0_g1_i1 O16025 AOSL_PLEHO 1.00E-32 GO:0047677; GO:0019369; GO:0004096; GO:0005737; GO:0020037; GO:0047987; GO:0005506; GO:0016020; GO:0031408 arachidonate 8(R)-lipoxygenase activity; arachidonic acid metabolic process; catalase activity; cytoplasm; heme binding; hydroperoxide dehydratase activity; iron ion binding; membrane; oxylipin biosynthetic process IPR020835; IPR011614; IPR008976; IPR000907; IPR013819; IPR020834; IPR020833; IPR001885; IPR001024; Lipid metabolism; arachidonate metabolism. Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (EC 4.2.1.92) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)] Plexaura homomalla (Black sea rod) TR11217_c1_g1_i1 Q8K0U4 HS12A_MOUSE 8.00E-07 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR11220_c1_g1_i1 Q9DEI1 PRKDC_XENLA 3.00E-30 GO:0005524; GO:0003677; GO:0004677; GO:0006303; GO:0070419; GO:0005730 ATP binding; DNA binding; DNA-dependent protein kinase activity; double-strand break repair via nonhomologous end joining; nonhomologous end joining complex; nucleolus IPR011989; IPR016024; IPR003152; IPR011009; IPR012582; IPR000403; IPR018936; IPR003151; IPR014009; DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) prkdc Xenopus laevis (African clawed frog) TR11220_c2_g1_i1 Q54UC0 PRKDC_DICDI 7.00E-12 GO:0005524; GO:0003677; GO:0006975; GO:0006310; GO:0004677; GO:0005958; GO:0006302; GO:0006303; GO:0004672 ATP binding; DNA binding; DNA damage induced protein phosphorylation; DNA recombination; DNA-dependent protein kinase activity; DNA-dependent protein kinase-DNA ligase 4 complex; double-strand break repair; double-strand break repair via nonhomologous end joining; protein kinase activity IPR016024; IPR003152; IPR011009; IPR012582; IPR000403; IPR018936; IPR003151; IPR014009; DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) dnapkcs DDB_G0281167 Dictyostelium discoideum (Slime mold) TR11221_c0_g1_i1 Q5REU2 RL23_PONAB 1.00E-45 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR019972; IPR023571; IPR000218; 60S ribosomal protein L23 RPL23 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR1123_c0_g1_i1 P82596 PLC_HALLA 1.00E-52 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR1124_c0_g1_i1 Q63HN8 RN213_HUMAN 3.00E-07 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR018957; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) TR11249_c0_g1_i1 P53001 AAT1_BACSU 2.00E-12 GO:0004069; GO:0080130; GO:0009058; GO:0005737; GO:0030170 L-aspartate:2-oxoglutarate aminotransferase activity; L-phenylalanine:2-oxoglutarate aminotransferase activity; biosynthetic process; cytoplasm; pyridoxal phosphate binding IPR004839; IPR004838; IPR015424; IPR015421; IPR015422; Aspartate aminotransferase (AspAT) (EC 2.6.1.1) (Transaminase A) aspB BSU22370 Bacillus subtilis (strain 168) TR11249_c0_g2_i1 E9L7A5 PAT_PETHY 1.00E-12 GO:0004069; GO:0009094; GO:0080130; GO:0009095; GO:0033853; GO:0009507; GO:0033854; GO:0042802; GO:0030170 "L-aspartate:2-oxoglutarate aminotransferase activity; L-phenylalanine biosynthetic process; L-phenylalanine:2-oxoglutarate aminotransferase activity; aromatic amino acid family biosynthetic process, prephenate pathway; aspartate-prephenate aminotransferase activity; chloroplast; glutamate-prephenate aminotransferase activity; identical protein binding; pyridoxal phosphate binding" IPR004839; IPR004838; IPR015424; IPR015421; IPR015422; Amino-acid biosynthesis; L-phenylalanine biosynthesis; L-arogenate from prephenate (L-Asp route): step 1/1. Amino-acid biosynthesis; L-phenylalanine biosynthesis; L-arogenate from prephenate (L-Glu route): step 1/1. Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase (PhPPA-AT) (EC 2.6.1.1) (EC 2.6.1.78) (EC 2.6.1.79) Petunia hybrida (Petunia) TR11251_c0_g1_i1 O75626 PRDM1_HUMAN 2.00E-08 GO:0045165; GO:0005737; GO:0001892; GO:0042462; GO:0007281; GO:0001893; GO:0046872; GO:0008168; GO:0030889; GO:0031665; GO:0000122; GO:0005634; GO:0045579; GO:0010628; GO:0043565; GO:0003700; GO:0006351 O75925; P63165 "cell fate commitment; cytoplasm; embryonic placenta development; eye photoreceptor cell development; germ cell development; maternal placenta development; metal ion binding; methyltransferase activity; negative regulation of B cell proliferation; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of B cell differentiation; positive regulation of gene expression; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001214; IPR007087; IPR015880; IPR013087; IPR016608; PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1) PRDM1 BLIMP1 Homo sapiens (Human) TR11252_c0_g1_i2 P16086 SPTN1_RAT 2.00E-66 GO:0031532; GO:0051693; GO:0005509; GO:0005829; GO:0005886; GO:0043234; GO:0008091 actin cytoskeleton reorganization; actin filament capping; calcium ion binding; cytosol; plasma membrane; protein complex; spectrin IPR011992; IPR014837; IPR018247; IPR002048; IPR001452; IPR018159; IPR013315; IPR002017; "Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain)" Sptan1 Spna2 Spta2 Rattus norvegicus (Rat) TR11257_c1_g1_i1 Q64701 RBL1_MOUSE 2.00E-60 GO:0007049; GO:0016568; GO:0000122; GO:0005634; GO:0051726; GO:0043550; GO:0005667; GO:0006351 Q155P7 "cell cycle; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; nucleus; regulation of cell cycle; regulation of lipid kinase activity; transcription factor complex; transcription, DNA-dependent" IPR013763; IPR002720; IPR002719; IPR015030; IPR028309; IPR024599; IPR028310; Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) Rbl1 Mus musculus (Mouse) TR11261_c0_g1_i1 Q5VXM1 CDCP2_HUMAN 3.00E-11 GO:0005576 extracellular region IPR000859; CUB domain-containing protein 2 CDCP2 Homo sapiens (Human) TR11266_c0_g2_i1 P56556 NDUA6_HUMAN 2.00E-38 GO:0008137; GO:0006120; GO:0005747; GO:0006979; GO:0044281 "NADH dehydrogenase (ubiquinone) activity; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I; response to oxidative stress; small molecule metabolic process" IPR008011; IPR016488; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (Complex I-B14) (CI-B14) (LYR motif-containing protein 6) (NADH-ubiquinone oxidoreductase B14 subunit) NDUFA6 LYRM6 NADHB14 Homo sapiens (Human) TR11275_c0_g2_i1 P08548 LIN1_NYCCO 1.00E-07 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR11278_c2_g1_i1 Q9ERU2 ZNF22_RAT 4.00E-06 GO:0003677; GO:0046872; GO:0005730; GO:0005634; GO:0042476; GO:0005886; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleolus; nucleus; odontogenesis; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 22 (Zinc finger protein Krox-25) Znf22 Krox25 Zfp422 Rattus norvegicus (Rat) TR11278_c2_g2_i1 O95625 ZBT11_HUMAN 1.00E-06 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 11 ZBTB11 Homo sapiens (Human) TR11290_c0_g2_i2 P53568 CEBPG_MOUSE 3.00E-14 GO:0030183; GO:0006338; GO:0003690; GO:0043353; GO:0001889; GO:0016071; GO:0042267; GO:0043433; GO:0006337; GO:0005634; GO:0045739; GO:0045078; GO:0046982; GO:0042803; GO:0006357; GO:0043565; GO:0008134; GO:0006351 "B cell differentiation; chromatin remodeling; double-stranded DNA binding; enucleate erythrocyte differentiation; liver development; mRNA metabolic process; natural killer cell mediated cytotoxicity; negative regulation of sequence-specific DNA binding transcription factor activity; nucleosome disassembly; nucleus; positive regulation of DNA repair; positive regulation of interferon-gamma biosynthetic process; protein heterodimerization activity; protein homodimerization activity; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding; transcription, DNA-dependent" IPR004827; CCAAT/enhancer-binding protein gamma (C/EBP gamma) (Granulocyte colony-stimulating factor promoter element 1-binding protein) (GPE1-BP) (GPE1-binding protein) (Immunoglobulin enhancer-binding protein 1) (IG/EBP-1) Cebpg Mus musculus (Mouse) TR11291_c1_g1_i1 Q6EE31 TCPQ_CHICK 1.00E-39 GO:0005524; GO:0005737; GO:0005815; GO:0006457 ATP binding; cytoplasm; microtubule organizing center; protein folding IPR012721; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) CCT8 Gallus gallus (Chicken) TR11292_c0_g2_i1 Q39610 DYHA_CHLRE 4.00E-39 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013602; IPR001298; IPR017868; IPR011043; IPR013783; IPR014756; IPR002909; IPR015915; IPR011498; IPR027417; IPR001736; "Dynein alpha chain, flagellar outer arm (DHC alpha)" ODA11 ODA-11 Chlamydomonas reinhardtii (Chlamydomonas smithii) TR11292_c1_g1_i1 P39057 DYHC_ANTCR 3.00E-78 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein beta chain, ciliary" Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR11315_c0_g1_i1 P13608 PGCA_BOVIN 5.00E-12 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 Q9UNA0; P49747 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Bos taurus (Bovine) TR11315_c0_g1_i2 P06734 FCER2_HUMAN 3.00E-17 GO:0007219; GO:0030246; GO:0009897; GO:0005576; GO:0005887; GO:0005178; GO:0046872; GO:0002925; GO:0051712; GO:0051000; GO:0051770 Notch signaling pathway; carbohydrate binding; external side of plasma membrane; extracellular region; integral to plasma membrane; integrin binding; metal ion binding; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of killing of cells of other organism; positive regulation of nitric-oxide synthase activity; positive regulation of nitric-oxide synthase biosynthetic process IPR001304; IPR016186; IPR018378; IPR016187; Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form] FCER2 CD23A CLEC4J FCE2 IGEBF Homo sapiens (Human) TR11324_c0_g1_i1 P51957 NEK4_HUMAN 1.00E-19 GO:0005524; GO:0051301; GO:0046872; GO:0007067; GO:0005634; GO:0004674 ATP binding; cell division; metal ion binding; mitosis; nucleus; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) NEK4 STK2 Homo sapiens (Human) TR11326_c0_g1_i1 A2AR95 LRAD3_MOUSE 4.00E-10 GO:0001540; GO:0016021; GO:0005886; GO:0006898; GO:0070613 beta-amyloid binding; integral to membrane; plasma membrane; receptor-mediated endocytosis; regulation of protein processing IPR023415; IPR002172; Low-density lipoprotein receptor class A domain-containing protein 3 Ldlrad3 Mus musculus (Mouse) TR1134_c0_g2_i1 Q3T0B7 RS27L_BOVIN 1.00E-48 GO:0046872; GO:0005840; GO:0003735; GO:0006412 metal ion binding; ribosome; structural constituent of ribosome; translation IPR000592; IPR023407; IPR011332; 40S ribosomal protein S27-like RPS27L Bos taurus (Bovine) TR11340_c1_g1_i1 Q6PB70 ANO8_MOUSE 5.00E-28 GO:0016021; GO:0005622; GO:0005886 integral to membrane; intracellular; plasma membrane IPR007632; Anoctamin-8 (Transmembrane protein 16H) Ano8 Kiaa1623 Tmem16h Mus musculus (Mouse) TR11349_c0_g1_i1 Q5JTW2 CEP78_HUMAN 9.00E-11 GO:0000086; GO:0005813; GO:0005829 G2/M transition of mitotic cell cycle; centrosome; cytosol IPR026212; Centrosomal protein of 78 kDa (Cep78) CEP78 C9orf81 Homo sapiens (Human) TR11354_c0_g1_i1 O96081 CALMB_HALRO 3.00E-21 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-B (CaM B) Halocynthia roretzi (Sea squirt) TR11355_c0_g1_i1 P19378 HSP7C_CRIGR 1.00E-28 GO:0005524; GO:0000974; GO:0008380; GO:0006397; GO:0042470; GO:0045892; GO:0005730; GO:0006950; GO:0030529; GO:0005681; GO:0006351 "ATP binding; Prp19 complex; RNA splicing; mRNA processing; melanosome; negative regulation of transcription, DNA-dependent; nucleolus; response to stress; ribonucleoprotein complex; spliceosomal complex; transcription, DNA-dependent" IPR018181; IPR013126; Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) HSPA8 HSC70 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR11361_c0_g1_i1 Q9EPQ1 TLR1_MOUSE 4.00E-14 GO:0002755; GO:0035354; GO:0007250; GO:0071727; GO:0006952; GO:0042495; GO:0006954; GO:0045087; GO:0016021; GO:0042116; GO:0016020; GO:0045335; GO:0030670; GO:0045410; GO:0042535; GO:0050707; GO:0034130; GO:0004888; GO:0042497 MyD88-dependent toll-like receptor signaling pathway; Toll-like receptor 1-Toll-like receptor 2 protein complex; activation of NF-kappaB-inducing kinase activity; cellular response to triacyl bacterial lipopeptide; defense response; detection of triacyl bacterial lipopeptide; inflammatory response; innate immune response; integral to membrane; macrophage activation; membrane; phagocytic vesicle; phagocytic vesicle membrane; positive regulation of interleukin-6 biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; regulation of cytokine secretion; toll-like receptor 1 signaling pathway; transmembrane signaling receptor activity; triacyl lipopeptide binding IPR000483; IPR001611; IPR025875; IPR000157; IPR027190; IPR017241; Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) Tlr1 Mus musculus (Mouse) TR11364_c0_g1_i1 Q9BZA8 PC11Y_HUMAN 1.00E-17 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR013164; IPR013585; Protocadherin-11 Y-linked (Protocadherin-11) (Protocadherin on the Y chromosome) (PCDH-Y) (Protocadherin prostate cancer) (Protocadherin-PC) (Protocadherin-22) PCDH11Y PCDH11 PCDH22 PCDHY Homo sapiens (Human) TR11372_c0_g2_i1 Q9P2E3 ZNFX1_HUMAN 8.00E-15 GO:0046872 metal ion binding IPR016024; IPR027417; NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) TR11374_c0_g1_i1 Q96MM6 HS12B_HUMAN 9.00E-07 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR11376_c0_g1_i1 Q9VW71 FAT2_DROME 4.00E-14 GO:0009925; GO:0005509; GO:0016339; GO:0050839; GO:0050829; GO:0042247; GO:0030950; GO:0005925; GO:0007440; GO:0007295; GO:0007442; GO:0007156; GO:0005887; GO:0045571; GO:0007424; GO:0045089; GO:0004872; GO:0007431 basal plasma membrane; calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; defense response to Gram-negative bacterium; establishment of planar polarity of follicular epithelium; establishment or maintenance of actin cytoskeleton polarity; focal adhesion; foregut morphogenesis; growth of a germarium-derived egg chamber; hindgut morphogenesis; homophilic cell adhesion; integral to plasma membrane; negative regulation of imaginal disc growth; open tracheal system development; positive regulation of innate immune response; receptor activity; salivary gland development IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Fat-like cadherin-related tumor suppressor homolog (Protein kugelei) kug fat2 CG7749 Drosophila melanogaster (Fruit fly) TR11379_c0_g1_i1 A2A9C3 SZT2_MOUSE 6.00E-48 GO:0007417; GO:0005777; GO:0043473; GO:0009791 central nervous system development; peroxisome; pigmentation; post-embryonic development Protein SZT2 (Seizure threshold 2 protein) (Transcript increased in glutamate resistance) (TIGR) Szt2 Mus musculus (Mouse) TR11383_c1_g1_i1 Q9Y5Q5 CORIN_HUMAN 1.00E-08 GO:0009986; GO:0005576; GO:0007565; GO:0016021; GO:0005887; GO:0016486; GO:0005886; GO:0006508; GO:0035813; GO:0003050; GO:0005044; GO:0004252; GO:0070008 cell surface; extracellular region; female pregnancy; integral to membrane; integral to plasma membrane; peptide hormone processing; plasma membrane; proteolysis; regulation of renal sodium excretion; regulation of systemic arterial blood pressure by atrial natriuretic peptide; scavenger receptor activity; serine-type endopeptidase activity; serine-type exopeptidase activity IPR020067; IPR023415; IPR002172; IPR001254; IPR018114; IPR017052; IPR017448; IPR009003; "Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Heart-specific serine proteinase ATC2) (Pro-ANP-converting enzyme) (Transmembrane protease serine 10) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]" CORIN CRN TMPRSS10 Homo sapiens (Human) TR11386_c1_g1_i1 A1A5X5 F132A_DANRE 6.00E-43 GO:0016055; GO:0005576; GO:0007275 Wnt receptor signaling pathway; extracellular region; multicellular organismal development IPR001073; IPR008983; IPR009143; Protein FAM132A fam132a c1qdc2 zgc:158358 Danio rerio (Zebrafish) (Brachydanio rerio) TR11418_c1_g1_i1 Q5JTW2 CEP78_HUMAN 5.00E-20 GO:0000086; GO:0005813; GO:0005829 G2/M transition of mitotic cell cycle; centrosome; cytosol IPR026212; Centrosomal protein of 78 kDa (Cep78) CEP78 C9orf81 Homo sapiens (Human) TR11433_c0_g1_i1 Q6XDT4 IKZF_OIKDI 2.00E-07 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Ikaros family zinc finger protein (Ikaros-like transcription factor) (OIL) Oikopleura dioica (Tunicate) TR11433_c1_g1_i1 Q92766 RREB1_HUMAN 2.00E-15 GO:0003677; GO:0007265; GO:0005737; GO:0046872; GO:0007275; GO:0045892; GO:0016604; GO:0016607; GO:0045893; GO:0003700; GO:0006366 "DNA binding; Ras protein signal transduction; cytoplasm; metal ion binding; multicellular organismal development; negative regulation of transcription, DNA-dependent; nuclear body; nuclear speck; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter" IPR007087; IPR015880; IPR013087; Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) RREB1 FINB Homo sapiens (Human) TR11444_c0_g1_i1 P10040 CRB_DROME 3.00E-10 GO:0016324; GO:0016327; GO:0005509; GO:0061336; GO:0046664; GO:0045198; GO:0016332; GO:0016334; GO:0016021; GO:0035002; GO:0035090; GO:0061024; GO:0045746; GO:0046621; GO:0048477; GO:0045494; GO:0008284; GO:0042327; GO:0008104; GO:0035330; GO:0045570; GO:0016028; GO:0042052; GO:0007435; GO:0005918; GO:0030507; GO:0035003; GO:0045186; GO:0045218 Q0E974 "apical plasma membrane; apicolateral plasma membrane; calcium ion binding; cell morphogenesis involved in Malpighian tubule morphogenesis; dorsal closure, amnioserosa morphology change; establishment of epithelial cell apical/basal polarity; establishment or maintenance of polarity of embryonic epithelium; establishment or maintenance of polarity of follicular epithelium; integral to membrane; liquid clearance, open tracheal system; maintenance of apical/basal cell polarity; membrane organization; negative regulation of Notch signaling pathway; negative regulation of organ growth; oogenesis; photoreceptor cell maintenance; positive regulation of cell proliferation; positive regulation of phosphorylation; protein localization; regulation of hippo signaling cascade; regulation of imaginal disc growth; rhabdomere; rhabdomere development; salivary gland morphogenesis; septate junction; spectrin binding; subapical complex; zonula adherens assembly; zonula adherens maintenance" IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protein crumbs (95F) crb CG6383 Drosophila melanogaster (Fruit fly) TR11445_c1_g1_i1 Q8BV66 IFI44_MOUSE 6.00E-06 GO:0005737 cytoplasm IPR024644; IPR027417; IPR006571; Interferon-induced protein 44 (Microtubule-associated protein 44) Ifi44 Mtap44 Mus musculus (Mouse) TR11445_c3_g1_i1 Q9BDB7 IF44L_MOUSE 8.00E-12 GO:0005737; GO:0006955 cytoplasm; immune response IPR024644; IPR027417; Interferon-induced protein 44-like [Cleaved into: Minor histocompatibility antigen HA-28 (HLA-HA28) (IFL8)] Ifi44l H28 Mus musculus (Mouse) TR11447_c3_g1_i1 Q9P0W8 SPAT7_HUMAN 5.00E-07 GO:0050896; GO:0007601 response to stimulus; visual perception Spermatogenesis-associated protein 7 (HSD-3.1) (Spermatogenesis-associated protein HSD3) SPATA7 HSD3 Homo sapiens (Human) TR11454_c0_g1_i1 Q9FPH0 XB34_ARATH 2.00E-10 GO:0016874; GO:0016567; GO:0008270 ligase activity; protein ubiquitination; zinc ion binding IPR002110; IPR020683; IPR001841; IPR013083; Protein modification; protein ubiquitination. Putative E3 ubiquitin-protein ligase XBAT34 (EC 6.3.2.-) (Ankyrin repeat domain and RING finger-containing protein XBAT34) (Protein XB3 homolog 4) XBAT34 At4g14365 dl3220c FCAALL.222 Arabidopsis thaliana (Mouse-ear cress) TR11462_c0_g1_i1 A8QZJ5 MCTX1_MILDI 4.00E-12 GO:0005576; GO:0042151 extracellular region; nematocyst IPR026645; Millepora cytotoxin-1 (MCTx-1) Millepora dichotoma (Net fire coral) TR11465_c0_g2_i1 A2ASS6 TITIN_MOUSE 2.00E-06 GO:0005524; GO:0031430; GO:0030018; GO:0007512; GO:0055003; GO:0043056; GO:0003007; GO:0001701; GO:0046872; GO:0006936; GO:0005859; GO:0005634; GO:0018108; GO:0004674; GO:0004713; GO:1901897; GO:0045214; GO:0001756; GO:0005200 ATP binding; M band; Z disc; adult heart development; cardiac myofibril assembly; forward locomotion; heart morphogenesis; in utero embryonic development; metal ion binding; muscle contraction; muscle myosin complex; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of relaxation of cardiac muscle; sarcomere organization; somitogenesis; structural constituent of cytoskeleton IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) TR11474_c1_g1_i1 Q98SP7 BBS2_DANRE 4.00E-18 GO:0070121; GO:0042384; GO:0060170; GO:0005737; GO:0007368; GO:0046907; GO:0032402; GO:0005815; GO:0051877 Kupffer's vesicle development; cilium assembly; cilium membrane; cytoplasm; determination of left/right symmetry; intracellular transport; melanosome transport; microtubule organizing center; pigment granule aggregation in cell center IPR016616; IPR015943; IPR017986; Bardet-Biedl syndrome 2 protein homolog bbs2 Danio rerio (Zebrafish) (Brachydanio rerio) TR11477_c0_g1_i1 Q8K4L3 SVIL_MOUSE 2.00E-18 GO:0030054; GO:0043034; GO:0007010; GO:0071437; GO:0005634; GO:0005886; GO:0002102; GO:0007519 cell junction; costamere; cytoskeleton organization; invadopodium; nucleus; plasma membrane; podosome; skeletal muscle tissue development IPR007123; IPR015628; IPR007122; IPR003128; Supervillin (Archvillin) (p205/p250) Svil Mus musculus (Mouse) TR11482_c1_g1_i1 Q8IY45 AMN1_HUMAN 5.00E-19 IPR026738; Protein AMN1 homolog AMN1 Homo sapiens (Human) TR11484_c0_g1_i1 Q96L46 CPNS2_HUMAN 1.00E-21 GO:0005509; GO:0005737; GO:0005886 calcium ion binding; cytoplasm; plasma membrane IPR011992; IPR002048; Calpain small subunit 2 (CSS2) (Calcium-dependent protease small subunit 2) CAPNS2 Homo sapiens (Human) TR11485_c1_g1_i1 Q91XQ0 DYH8_MOUSE 4.00E-61 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018; GO:0031514 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement; motile cilium IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 8, axonemal (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8)" Dnahc8 Mus musculus (Mouse) TR11496_c0_g2_i1 Q99758 ABCA3_HUMAN 1.00E-08 GO:0005524; GO:0042626; GO:0097208; GO:0097233; GO:0016021; GO:0005886; GO:0042493 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; alveolar lamellar body; alveolar lamellar body membrane; integral to membrane; plasma membrane; response to drug" IPR003593; IPR026082; IPR003439; IPR017871; IPR026969; IPR027417; ATP-binding cassette sub-family A member 3 (ABC-C transporter) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) ABCA3 ABC3 Homo sapiens (Human) TR11506_c1_g1_i1 Q2WEA5 TRPM1_RAT 3.00E-13 GO:0007216; GO:0005262; GO:0060402; GO:0016021; GO:0005886 G-protein coupled glutamate receptor signaling pathway; calcium channel activity; calcium ion transport into cytosol; integral to membrane; plasma membrane IPR005821; Transient receptor potential cation channel subfamily M member 1 (Melastatin-1) Trpm1 Rattus norvegicus (Rat) TR11509_c0_g1_i1 Q91727 CDK4_XENLA 2.00E-08 GO:0005524; GO:0051301; GO:0004693 P50755; Q6GLD3 ATP binding; cell division; cyclin-dependent protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) cdk4 Xenopus laevis (African clawed frog) TR11520_c0_g1_i1 Q8WZ42 TITIN_HUMAN 2.00E-18 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR11529_c3_g1_i1 Q80U35 ARHGH_MOUSE 3.00E-24 GO:0005089; GO:0030036; GO:0035023 Rho guanyl-nucleotide exchange factor activity; actin cytoskeleton organization; regulation of Rho protein signal transduction IPR000219; IPR011993; IPR015943; IPR017986; Rho guanine nucleotide exchange factor 17 Arhgef17 Kiaa0337 Mus musculus (Mouse) TR11538_c0_g1_i1 Q6UWX4 HIPL2_HUMAN 1.00E-20 GO:0005975; GO:0005576; GO:0016901; GO:0048038 "carbohydrate metabolic process; extracellular region; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor; quinone binding" IPR011042; IPR018143; IPR012938; IPR011041; HHIP-like protein 2 HHIPL2 HHIP3 KIAA1822L UNQ841/PRO1779 Homo sapiens (Human) TR11551_c0_g2_i1 Q01538 MYT1_HUMAN 3.00E-09 GO:0003677; GO:0030154; GO:0007399; GO:0005634; GO:0003700; GO:0006351; GO:0008270 "DNA binding; cell differentiation; nervous system development; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR013681; IPR002515; Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) MYT1 KIAA0835 KIAA1050 MTF1 MYTI PLPB1 Homo sapiens (Human) TR11554_c0_g1_i1 P35750 CAN1_PIG 4.00E-23 GO:0005509; GO:0004198; GO:0005737; GO:0005886; GO:0006508; GO:0032801 calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cytoplasm; plasma membrane; proteolysis; receptor catabolic process IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Micromolar-calpain) (muCANP) CAPN1 Sus scrofa (Pig) TR11557_c2_g1_i1 Q02246 CNTN2_HUMAN 2.00E-08 GO:0007628; GO:0031225; GO:0007411; GO:0007413; GO:0030246; GO:0007155; GO:0009986; GO:0034613; GO:0022010; GO:0021853; GO:0045163; GO:0071206; GO:0042802; GO:0005887; GO:0044224; GO:0007612; GO:0000226; GO:0043209; GO:0045665; GO:0001764; GO:0043025; GO:0033268; GO:0060168; GO:0010954; GO:0031623; GO:0048710; GO:0031133; GO:0048168; GO:0045202; GO:0008076 adult walking behavior; anchored to membrane; axon guidance; axonal fasciculation; carbohydrate binding; cell adhesion; cell surface; cellular protein localization; central nervous system myelination; cerebral cortex GABAergic interneuron migration; clustering of voltage-gated potassium channels; establishment of protein localization to juxtaparanode region of axon; identical protein binding; integral to plasma membrane; juxtaparanode region of axon; learning; microtubule cytoskeleton organization; myelin sheath; negative regulation of neuron differentiation; neuron migration; neuronal cell body; node of Ranvier; positive regulation of adenosine receptor signaling pathway; positive regulation of protein processing; receptor internalization; regulation of astrocyte differentiation; regulation of axon diameter; regulation of neuronal synaptic plasticity; synapse; voltage-gated potassium channel complex IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Contactin-2 (Axonal glycoprotein TAG-1) (Axonin-1) (Transient axonal glycoprotein 1) (TAX-1) CNTN2 AXT TAG1 TAX1 Homo sapiens (Human) TR11564_c1_g1_i1 Q8IYT3 CC170_HUMAN 3.00E-17 Coiled-coil domain-containing protein 170 CCDC170 C6orf97 Homo sapiens (Human) TR11573_c1_g1_i1 Q8K0U4 HS12A_MOUSE 1.00E-10 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR11584_c0_g1_i1 Q8K2J9 BTBD6_MOUSE 9.00E-10 GO:0000932 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6 Btbd6 Mus musculus (Mouse) TR11590_c1_g1_i1 B4MR28 PTK7_DROWI 2.00E-06 GO:0005524; GO:0007155; GO:0050839; GO:0016021; GO:0018108; GO:0005886; GO:0004672; GO:0004713; GO:0004872; GO:0031290 ATP binding; cell adhesion; cell adhesion molecule binding; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; protein kinase activity; protein tyrosine kinase activity; receptor activity; retinal ganglion cell axon guidance IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase-like otk (Tyrosine-protein kinase-like 7 homolog) otk GK21983 Drosophila willistoni (Fruit fly) TR11597_c0_g2_i1 P97329 KI20A_MOUSE 2.00E-17 GO:0005524; GO:0005794; GO:0000910; GO:0005871; GO:0005874; GO:0001578; GO:0003777; GO:0007018; GO:0015031; GO:0005819 ATP binding; Golgi apparatus; cytokinesis; kinesin complex; microtubule; microtubule bundle formation; microtubule motor activity; microtubule-based movement; protein transport; spindle IPR027326; IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF20A (Kinesin-like protein 174) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) Kif20a Rab6kifl Mus musculus (Mouse) TR11601_c0_g2_i1 Q6P5D8 SMHD1_MOUSE 4.00E-32 GO:0005524; GO:0001740; GO:0051276; GO:0060821 ATP binding; Barr body; chromosome organization; inactivation of X chromosome by DNA methylation IPR003594; IPR010935; Structural maintenance of chromosomes flexible hinge domain-containing protein 1 Smchd1 Kiaa0650 Mus musculus (Mouse) TR11619_c2_g1_i1 Q9VAC5 ADA17_DROME 4.00E-32 GO:0016021; GO:0006509; GO:0004222; GO:0008270 integral to membrane; membrane protein ectodomain proteolysis; metalloendopeptidase activity; zinc ion binding IPR001762; IPR024079; IPR001590; IPR002870; ADAM 17-like protease (EC 3.4.24.-) Tace CG7908 Drosophila melanogaster (Fruit fly) TR11630_c3_g1_i1 Q8VBV4 FBXW7_MOUSE 3.00E-13 GO:0005794; GO:0007219; GO:0019005; GO:0031146; GO:0005783; GO:0030324; GO:0005634; GO:0048471; GO:0016567; GO:0003700; GO:0001570 Golgi apparatus; Notch signaling pathway; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; endoplasmic reticulum; lung development; nucleus; perinuclear region of cytoplasm; protein ubiquitination; sequence-specific DNA binding transcription factor activity; vasculogenesis IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10) Fbxw7 Fbw7 Fbwd6 Fbxw6 Mus musculus (Mouse) TR11632_c0_g1_i1 Q8TD57 DYH3_HUMAN 3.00E-37 GO:0005524; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR026983; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 3, axonemal (Axonemal beta dynein heavy chain 3) (HsADHC3) (Ciliary dynein heavy chain 3) (Dnahc3-b)" DNAH3 DNAHC3B Homo sapiens (Human) TR11632_c1_g1_i1 Q8BW94 DYH3_MOUSE 4.00E-32 GO:0005524; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR026983; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 3, axonemal (Axonemal beta dynein heavy chain 3) (Ciliary dynein heavy chain 3)" Dnah3 Dnahc3 Mus musculus (Mouse) TR11633_c0_g1_i1 O15145 ARPC3_HUMAN 9.00E-07 GO:0034314; GO:0005885; GO:0038096; GO:0006928; GO:0005829; GO:0045087; GO:0030027; GO:0005200 Arp2/3 complex-mediated actin nucleation; Arp2/3 protein complex; Fc-gamma receptor signaling pathway involved in phagocytosis; cellular component movement; cytosol; innate immune response; lamellipodium; structural constituent of cytoskeleton IPR007204; Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC) ARPC3 ARC21 Homo sapiens (Human) TR11635_c0_g2_i1 Q6P9I7 SMC6_XENLA 2.00E-26 GO:0005524; GO:0016605; GO:0030915; GO:0090398; GO:0000781; GO:0000724; GO:0000722 "ATP binding; PML body; Smc5-Smc6 complex; cellular senescence; chromosome, telomeric region; double-strand break repair via homologous recombination; telomere maintenance via recombination" IPR027417; IPR003395; IPR027132; IPR010935; Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (xSMC6) smc6 smc6l1 Xenopus laevis (African clawed frog) TR11637_c1_g1_i1 P57101 HAND2_XENLA 9.00E-06 GO:0003677; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011598; "Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND)" hand2 dhand Xenopus laevis (African clawed frog) TR11640_c0_g1_i1 Q9Y2X3 NOP58_HUMAN 4.00E-22 GO:0015030; GO:0031428; GO:0016049; GO:0005737; GO:0070761; GO:0006364; GO:0006608; GO:0030515 Q96RS0 Cajal body; box C/D snoRNP complex; cell growth; cytoplasm; pre-snoRNP complex; rRNA processing; snRNP protein import into nucleus; snoRNA binding IPR012974; IPR002687; IPR012976; Nucleolar protein 58 (Nucleolar protein 5) NOP58 NOL5 NOP5 HSPC120 Homo sapiens (Human) TR11640_c1_g1_i1 Q3V2Q8 N42L1_MOUSE 5.00E-18 IPR026567; IPR027417; NEDD4-binding protein 2-like 1 N4bp2l1 Mus musculus (Mouse) TR11641_c1_g1_i1 B0S5Y3 S5A3A_DANRE 1.00E-66 GO:0016021; GO:0005886; GO:0006810 integral to membrane; plasma membrane; transport IPR009357; "Solute carrier family 52, riboflavin transporter, member 3-A (Riboflavin transporter 2-A) (RFT2-A)" slc52a3a rft2a si:dkeyp-53e12.7 zgc:136909 Danio rerio (Zebrafish) (Brachydanio rerio) TR11642_c1_g1_i1 P47236 PAX1_CHICK 1.00E-29 GO:0003677; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009057; IPR001523; IPR011991; Paired box protein Pax-1 (Fragment) PAX1 GPX-1 Gallus gallus (Chicken) TR11648_c0_g1_i1 Q3KP44 ANR55_HUMAN 1.00E-06 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 55 ANKRD55 Homo sapiens (Human) TR11648_c1_g1_i1 P16157 ANK1_HUMAN 1.00E-19 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR11649_c0_g1_i1 H2A0L1 TYRO2_PINMG 7.00E-15 GO:0005576; GO:0046872; GO:0016491 extracellular region; metal ion binding; oxidoreductase activity IPR002227; IPR008922; Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2) Pinctada margaritifera (Black-lipped pearl oyster) TR11651_c0_g1_i1 Q92090 CP2K1_ONCMY 1.00E-36 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 2K1 (EC 1.14.14.1) (CYPIIK1) (Cytochrome P450 LMC2) cyp2k1 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR11651_c1_g1_i1 Q54D38 C520A_DICDI 2.00E-06 GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705 "heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Probable cytochrome P450 520A1 (EC 1.14.-.-) cyp520A1 DDB_G0292496 Dictyostelium discoideum (Slime mold) TR11653_c0_g1_i1 Q04721 NOTC2_HUMAN 1.00E-24 GO:0000139; GO:0007220; GO:0061314; GO:0006915; GO:0060413; GO:0046849; GO:0005509; GO:0007050; GO:0001709; GO:0016049; GO:0009986; GO:0005789; GO:0005576; GO:0030097; GO:0005887; GO:0043066; GO:0008285; GO:0007399; GO:0005654; GO:0046579; GO:0003184; GO:0004872; GO:0006355; GO:0019827; GO:0006367 "Golgi membrane; Notch receptor processing; Notch signaling involved in heart development; apoptotic process; atrial septum morphogenesis; bone remodeling; calcium ion binding; cell cycle arrest; cell fate determination; cell growth; cell surface; endoplasmic reticulum membrane; extracellular region; hemopoiesis; integral to plasma membrane; negative regulation of apoptotic process; negative regulation of cell proliferation; nervous system development; nucleoplasm; positive regulation of Ras protein signal transduction; pulmonary valve morphogenesis; receptor activity; regulation of transcription, DNA-dependent; stem cell maintenance; transcription initiation from RNA polymerase II promoter" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022336; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation; Notch 2 intracellular domain] NOTCH2 Homo sapiens (Human) TR11658_c0_g1_i1 O73817 PSB3_ONCMY 2.00E-71 GO:0005737; GO:0005634; GO:0005839; GO:0051603; GO:0004298 cytoplasm; nucleus; proteasome core complex; proteolysis involved in cellular protein catabolic process; threonine-type endopeptidase activity IPR016050; IPR001353; IPR023333; Proteasome subunit beta type-3 (EC 3.4.25.1) (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain) psmb3 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR11663_c0_g1_i1 C3YWU0 FUCO_BRAFL 1.00E-45 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR11663_c0_g2_i1 P17164 FUCO_RAT 7.00E-45 GO:0004560; GO:0042806; GO:0006004; GO:0016139; GO:0005764 alpha-L-fucosidase activity; fucose binding; fucose metabolic process; glycoside catabolic process; lysosome IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) Fuca1 Fuca Rattus norvegicus (Rat) TR11665_c0_g1_i1 Q53RE8 ANR39_HUMAN 2.00E-06 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 39 ANKRD39 HSPC200 Homo sapiens (Human) TR11667_c1_g1_i1 Q6ZMV9 KIF6_HUMAN 5.00E-98 GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0007018 Q92624 ATP binding; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF6 KIF6 C6orf102 Homo sapiens (Human) TR11675_c0_g1_i1 Q5SPC5 OTOF_DANRE 2.00E-27 GO:0016323; GO:0005509; GO:0030054; GO:0005789; GO:0016021; GO:0016079; GO:0030672 basolateral plasma membrane; calcium ion binding; cell junction; endoplasmic reticulum membrane; integral to membrane; synaptic vesicle exocytosis; synaptic vesicle membrane IPR000008; IPR012968; IPR012561; Otoferlin (Fer-1-like protein 2) otof fer1l2 si:dkey-181f18.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR11675_c1_g1_i1 Q9ESF1 OTOF_MOUSE 3.00E-26 GO:0016323; GO:0005509; GO:0030054; GO:0005789; GO:0016021; GO:0007605; GO:0016079; GO:0030672 basolateral plasma membrane; calcium ion binding; cell junction; endoplasmic reticulum membrane; integral to membrane; sensory perception of sound; synaptic vesicle exocytosis; synaptic vesicle membrane IPR000008; IPR012968; IPR012561; Otoferlin (Fer-1-like protein 2) Otof Fer1l2 Mus musculus (Mouse) TR11676_c1_g1_i1 Q9CZJ2 HS12B_MOUSE 3.00E-18 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR11685_c0_g1_i1 Q3SX04 T3HPD_BOVIN 2.00E-22 GO:0016836; GO:0050346 hydro-lyase activity; trans-L-3-hydroxyproline dehydratase activity IPR008794; Trans-L-3-hydroxyproline dehydratase (EC 4.2.1.77) (Trans-3-hydroxy-l-proline dehydratase) L3HYPDH Bos taurus (Bovine) TR11687_c0_g3_i1 P26011 ITB7_MOUSE 4.00E-12 GO:0007160; GO:0008305; GO:0007229; GO:0050900; GO:0007275; GO:0004872 cell-matrix adhesion; integrin complex; integrin-mediated signaling pathway; leukocyte migration; multicellular organismal development; receptor activity IPR013111; IPR015812; IPR015437; IPR014836; IPR002369; IPR012896; IPR016201; IPR002035; Integrin beta-7 (Integrin beta-P) (M290 IEL antigen) Itgb7 Mus musculus (Mouse) TR11698_c0_g1_i1 Q27245 YH24_CAEEL 9.00E-39 GO:0004177; GO:0005737; GO:0030145; GO:0008235; GO:0006508 aminopeptidase activity; cytoplasm; manganese ion binding; metalloexopeptidase activity; proteolysis IPR011356; IPR000819; Putative aminopeptidase W07G4.4 (EC 3.4.11.-) W07G4.4 Caenorhabditis elegans TR11708_c3_g1_i1 Q5VT06 CE350_HUMAN 5.00E-15 GO:0005813; GO:0005737; GO:0005634; GO:0005819 centrosome; cytoplasm; nucleus; spindle IPR000938; Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) CEP350 CAP350 KIAA0480 GM133 Homo sapiens (Human) TR11712_c0_g1_i1 P18445 RL27A_RAT 2.00E-62 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001196; IPR021131; 60S ribosomal protein L27a Rpl27a Rattus norvegicus (Rat) TR11713_c0_g1_i1 Q9U489 LIN41_CAEEL 4.00E-25 GO:0005737; GO:0009957; GO:0007276; GO:0044268; GO:0042787; GO:0040034; GO:0045604; GO:0045138; GO:0004842; GO:0008270 "cytoplasm; epidermal cell fate specification; gamete generation; multicellular organismal protein metabolic process; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of development, heterochronic; regulation of epidermal cell differentiation; tail tip morphogenesis; ubiquitin-protein ligase activity; zinc ion binding" IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; Protein lin-41 (Abnormal cell lineage protein 41) lin-41 C12C8.3 Caenorhabditis elegans TR11722_c0_g1_i1 Q90953 CSPG2_CHICK 2.00E-17 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Gallus gallus (Chicken) TR11726_c0_g1_i1 Q16706 MA2A1_HUMAN 6.00E-06 GO:0000139; GO:0006491; GO:0030246; GO:0016799; GO:0001701; GO:0016021; GO:0001889; GO:0048286; GO:0006013; GO:0004572; GO:0007005; GO:0043687; GO:0018279; GO:0007585; GO:0007033; GO:0008270 "Golgi membrane; N-glycan processing; carbohydrate binding; hydrolase activity, hydrolyzing N-glycosyl compounds; in utero embryonic development; integral to membrane; liver development; lung alveolus development; mannose metabolic process; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity; mitochondrion organization; post-translational protein modification; protein N-linked glycosylation via asparagine; respiratory gaseous exchange; vacuole organization; zinc ion binding" IPR011013; IPR011330; IPR013780; IPR027291; IPR011682; IPR015341; IPR000602; Protein modification; protein glycosylation. "Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)" MAN2A1 MANA2 Homo sapiens (Human) TR11736_c0_g1_i1 Q6ZWR6 SYNE1_MOUSE 3.00E-06 GO:0005856; GO:0040023; GO:0016021; GO:0005635; GO:0005640; GO:0042803; GO:0030017 cytoskeleton; establishment of nucleus localization; integral to membrane; nuclear envelope; nuclear outer membrane; protein homodimerization activity; sarcomere IPR001589; IPR001715; IPR012315; IPR018159; IPR002017; Nesprin-1 (Enaptin) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) Syne1 Mus musculus (Mouse) TR11737_c0_g1_i1 Q460N5 PAR14_HUMAN 8.00E-10 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR11738_c1_g1_i1 Q28811 PHR_POTTR 1.00E-26 GO:0003677; GO:0006281; GO:0003904; GO:0018298 DNA binding; DNA repair; deoxyribodipyrimidine photo-lyase activity; protein-chromophore linkage IPR008148; IPR006050; IPR005101; IPR014729; Deoxyribodipyrimidine photo-lyase (EC 4.1.99.3) (DNA photolyase) (Photoreactivating enzyme) PHR Potorous tridactylus (Potoroo) TR11739_c0_g1_i1 P0CB85 NDUB8_PONAB 9.00E-23 GO:0008137; GO:0016021; GO:0006120; GO:0005747 "NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I" IPR016551; IPR008699; "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (Complex I-ASHI) (CI-ASHI) (NADH-ubiquinone oxidoreductase ASHI subunit)" NDUFB8 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR11742_c0_g1_i1 P86855 PWAPL_MYTGA 8.00E-47 GO:0005576; GO:0010466; GO:0030414 extracellular region; negative regulation of peptidase activity; peptidase inhibitor activity IPR008197; Perlwapin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR11746_c0_g2_i1 A2A935 PRD16_MOUSE 5.00E-06 GO:0050873; GO:0046872; GO:0030853; GO:0000122; GO:0030512; GO:0022008; GO:0060021; GO:0045893; GO:0043457; GO:0043565; GO:0035019; GO:0043586; GO:0003713; GO:0006351; GO:0017053; GO:0050872 "brown fat cell differentiation; metal ion binding; negative regulation of granulocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; neurogenesis; palate development; positive regulation of transcription, DNA-dependent; regulation of cellular respiration; sequence-specific DNA binding; somatic stem cell maintenance; tongue development; transcription coactivator activity; transcription, DNA-dependent; transcriptional repressor complex; white fat cell differentiation" IPR001214; IPR007087; IPR015880; IPR013087; PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) Prdm16 Kiaa1675 Mel1 Mus musculus (Mouse) TR11749_c0_g1_i1 A2ASS6 TITIN_MOUSE 7.00E-12 GO:0005524; GO:0031430; GO:0030018; GO:0007512; GO:0055003; GO:0043056; GO:0003007; GO:0001701; GO:0046872; GO:0006936; GO:0005859; GO:0005634; GO:0018108; GO:0004674; GO:0004713; GO:1901897; GO:0045214; GO:0001756; GO:0005200 ATP binding; M band; Z disc; adult heart development; cardiac myofibril assembly; forward locomotion; heart morphogenesis; in utero embryonic development; metal ion binding; muscle contraction; muscle myosin complex; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of relaxation of cardiac muscle; sarcomere organization; somitogenesis; structural constituent of cytoskeleton IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) TR11754_c1_g1_i1 P84675 PFM_CHAGB 9.00E-06 GO:0050832; GO:0031640 defense response to fungus; killing of cells of other organism IPR002889; IPR013994; Putative fungistatic metabolite CHGG_05463 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) TR11763_c1_g1_i1 A6QPA3 BTBDJ_BOVIN 1.00E-24 IPR011705; IPR000210; IPR011333; IPR013069; BTB/POZ domain-containing protein 19 BTBD19 Bos taurus (Bovine) TR11763_c3_g1_i1 Q0IHH9 SPOPB_XENLA 6.00E-13 GO:0031463; GO:0016607; GO:0005634; GO:0043161; GO:0016567 Cul3-RING ubiquitin ligase complex; nuclear speck; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination IPR000210; IPR011333; IPR013069; IPR002083; IPR008974; Protein modification; protein ubiquitination. Speckle-type POZ protein B spop-b Xenopus laevis (African clawed frog) TR11766_c0_g1_i1 Q5RC80 RBM39_PONAB 1.00E-66 GO:0003723; GO:0008380; GO:0006397; GO:0016607; GO:0000166; GO:0006355; GO:0006351 "RNA binding; RNA splicing; mRNA processing; nuclear speck; nucleotide binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006509; IPR012677; IPR000504; RNA-binding protein 39 (RNA-binding motif protein 39) RBM39 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR1177_c0_g1_i1 P28841 NEC2_RAT 7.00E-20 GO:0030425; GO:0009790; GO:0034230; GO:0005615; GO:0030070; GO:0034231; GO:0016020; GO:0007399; GO:0043204; GO:0016540; GO:0006508; GO:0004252; GO:0030133 P27682 dendrite; embryo development; enkephalin processing; extracellular space; insulin processing; islet amyloid polypeptide processing; membrane; nervous system development; perikaryon; protein autoprocessing; proteolysis; serine-type endopeptidase activity; transport vesicle IPR008979; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2) Pcsk2 Nec-2 Nec2 Rpc2 Rattus norvegicus (Rat) TR11779_c1_g1_i1 Q8N1F8 S11IP_HUMAN 4.00E-14 GO:0005765; GO:0008104 lysosomal membrane; protein localization IPR001611; Serine/threonine-protein kinase 11-interacting protein (LKB1-interacting protein 1) STK11IP KIAA1898 LIP1 LKB1IP STK11IP1 Homo sapiens (Human) TR11781_c0_g1_i1 O88658 KIF1B_RAT 4.00E-43 GO:0005524; GO:0016887; GO:0008089; GO:0030659; GO:0005871; GO:0005874; GO:0005875; GO:0003777; GO:0005739; GO:0007274; GO:0043005; GO:0007270; GO:0005543 P61023 ATP binding; ATPase activity; anterograde axon cargo transport; cytoplasmic vesicle membrane; kinesin complex; microtubule; microtubule associated complex; microtubule motor activity; mitochondrion; neuromuscular synaptic transmission; neuron projection; neuron-neuron synaptic transmission; phospholipid binding IPR000253; IPR022140; IPR022164; IPR027640; IPR019821; IPR001752; IPR027417; IPR011993; IPR001849; IPR008984; Kinesin-like protein KIF1B Kif1b Rattus norvegicus (Rat) TR11786_c0_g3_i1 A4IF63 TRIM2_BOVIN 2.00E-19 GO:0005737; GO:0043523; GO:0004842; GO:0008270 cytoplasm; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) TR11788_c0_g1_i1 Q8ISH7 FCAP_APLCA 2.00E-10 GO:0005576; GO:0007218 extracellular region; neuropeptide signaling pathway Feeding circuit activating peptides (FCAP) [Cleaved into: Feeding circuit activating peptide a (FCAPa); Feeding circuit activating peptide b (FCAPb); Feeding circuit activating peptide c (FCAPc); Feeding circuit activating peptide d (FCAPd); Feeding circuit activating peptide e (FCAPe); Feeding circuit activating peptide f (FCAPf); Feeding circuit activating peptide g (FCAPg); Feeding circuit activating peptide h (FCAPh)] Aplysia californica (California sea hare) TR11802_c0_g1_i1 Q96LX8 ZN597_HUMAN 1.00E-18 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 597 ZNF597 Homo sapiens (Human) TR11802_c0_g1_i2 Q6ZMW2 ZN782_HUMAN 1.00E-32 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 782 ZNF782 Homo sapiens (Human) TR11806_c0_g1_i1 Q8BX70 VP13C_MOUSE 1.00E-25 IPR015412; IPR026847; IPR026854; IPR009543; Vacuolar protein sorting-associated protein 13C Vps13c Kiaa3021 Mus musculus (Mouse) TR11806_c1_g1_i1 Q96RL7 VP13A_HUMAN 3.00E-17 GO:0006895; GO:0008219; GO:0031045; GO:0005622; GO:0007626; GO:0007399; GO:0008104; GO:0015031; GO:0035176 P16333 Golgi to endosome transport; cell death; dense core granule; intracellular; locomotory behavior; nervous system development; protein localization; protein transport; social behavior IPR015412; IPR026847; IPR026854; IPR009543; Vacuolar protein sorting-associated protein 13A (Chorea-acanthocytosis protein) (Chorein) VPS13A CHAC KIAA0986 Homo sapiens (Human) TR1181_c0_g1_i1 Q8TEU7 RPGF6_HUMAN 6.00E-31 GO:0030742; GO:0017016; GO:0007265; GO:0005737; GO:0005085; GO:0005886; GO:0043087; GO:0051056 Q12923 GTP-dependent protein binding; Ras GTPase binding; Ras protein signal transduction; cytoplasm; guanyl-nucleotide exchange factor activity; plasma membrane; regulation of GTPase activity; regulation of small GTPase mediated signal transduction IPR018490; IPR000595; IPR001478; IPR000159; IPR000651; IPR008937; IPR023578; IPR001895; IPR014710; Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) RAPGEF6 PDZGEF2 Homo sapiens (Human) TR11813_c0_g2_i1 Q8NHV1 GIMA7_HUMAN 9.00E-32 GO:0005525; GO:0003924; GO:0005811 GTP binding; GTPase activity; lipid particle IPR006703; IPR027417; GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) TR11814_c1_g1_i1 P49013 FBP3_STRPU 2.00E-40 GO:0005509; GO:0005615 calcium ion binding; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) TR11819_c0_g1_i1 Q9P2K8 E2AK4_HUMAN 7.00E-30 GO:0005524; GO:0009267; GO:0022626; GO:0030968; GO:0004694; GO:0017148; GO:0006446; GO:0043558 ATP binding; cellular response to starvation; cytosolic ribosome; endoplasmic reticulum unfolded protein response; eukaryotic translation initiation factor 2alpha kinase activity; negative regulation of translation; regulation of translational initiation; regulation of translational initiation in response to stress IPR004154; IPR024435; IPR011009; IPR000719; IPR017441; IPR006575; IPR008271; IPR016255; IPR016135; Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) EIF2AK4 GCN2 KIAA1338 Homo sapiens (Human) TR1182_c0_g1_i1 Q00780 CO8A1_MOUSE 7.00E-07 GO:0001525; GO:0005604; GO:0048593; GO:0007155; GO:0005581; GO:0050673; GO:0010811 angiogenesis; basement membrane; camera-type eye morphogenesis; cell adhesion; collagen; epithelial cell proliferation; positive regulation of cell-substrate adhesion IPR001073; IPR008160; IPR008983; Collagen alpha-1(VIII) chain [Cleaved into: Vastatin] Col8a1 Mus musculus (Mouse) TR11821_c1_g1_i1 O75964 ATP5L_HUMAN 2.00E-12 GO:0006200; GO:0015078; GO:0042776; GO:0005753; GO:0000276; GO:0022904; GO:0022857 "ATP catabolic process; hydrogen ion transmembrane transporter activity; mitochondrial ATP synthesis coupled proton transport; mitochondrial proton-transporting ATP synthase complex; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); respiratory electron transport chain; transmembrane transporter activity" IPR016702; IPR006808; "ATP synthase subunit g, mitochondrial (ATPase subunit g)" ATP5L Homo sapiens (Human) TR11828_c0_g1_i1 Q2TBI2 THAP4_BOVIN 1.00E-08 GO:0003677; GO:0046872 DNA binding; metal ion binding IPR011038; IPR014878; IPR006612; THAP domain-containing protein 4 THAP4 Bos taurus (Bovine) TR11841_c0_g1_i1 Q9NPA5 ZF64A_HUMAN 5.00E-20 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; "Zinc finger protein 64 homolog, isoforms 1 and 2 (Zfp-64) (Zinc finger protein 338)" ZFP64 ZNF338 Homo sapiens (Human) TR11844_c1_g1_i1 D9HP27 CNR11_MAIZE 4.00E-07 GO:0016021 integral to membrane IPR006461; Cell number regulator 11 (ZmCNR11) CNR11 Zea mays (Maize) TR11858_c1_g1_i1 Q0KI50 DMDD_DROME 1.00E-24 GO:0003779; GO:0005509; GO:0005737; GO:0005856; GO:0016010; GO:0030010; GO:0008586; GO:0007474; GO:0046716; GO:0007517; GO:0007274; GO:0046928; GO:0048172; GO:0042383; GO:0005198; GO:0045202; GO:0008270 actin binding; calcium ion binding; cytoplasm; cytoskeleton; dystrophin-associated glycoprotein complex; establishment of cell polarity; imaginal disc-derived wing vein morphogenesis; imaginal disc-derived wing vein specification; muscle cell cellular homeostasis; muscle organ development; neuromuscular synaptic transmission; regulation of neurotransmitter secretion; regulation of short-term neuronal synaptic plasticity; sarcolemma; structural molecule activity; synapse; zinc ion binding IPR011992; IPR015153; IPR015154; IPR018159; IPR001202; IPR000433; "Dystrophin, isoform D (Protein detached)" Dys det CG34157 Drosophila melanogaster (Fruit fly) TR11862_c1_g1_i1 Q9EQZ7 RIMS2_MOUSE 2.00E-36 GO:0019933; GO:0017156; GO:0048791; GO:0030054; GO:0030073; GO:0006886; GO:0044325; GO:0046872; GO:0043005; GO:0006836; GO:0017157; GO:0042391; GO:0045202 cAMP-mediated signaling; calcium ion-dependent exocytosis; calcium ion-dependent exocytosis of neurotransmitter; cell junction; insulin secretion; intracellular protein transport; ion channel binding; metal ion binding; neuron projection; neurotransmitter transport; regulation of exocytosis; regulation of membrane potential; synapse IPR000008; IPR001478; IPR017455; IPR010911; IPR011011; IPR013083; Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 2) Rims2 Rab3ip2 Rim2 Mus musculus (Mouse) TR11866_c2_g1_i1 A6PWD2 FHAD1_MOUSE 2.00E-10 IPR000253; IPR008984; Forkhead-associated domain-containing protein 1 (FHA domain-containing protein 1) Fhad1 Mus musculus (Mouse) TR11876_c1_g1_i1 P80109 PHLD_BOVIN 3.00E-08 GO:0006507; GO:0002042; GO:0071277; GO:0071397; GO:0035690; GO:0071467; GO:0071401; GO:0002062; GO:0002430; GO:0005737; GO:0005615; GO:0004621; GO:0034364; GO:0008286; GO:0043231; GO:0008285; GO:0010897; GO:0001503; GO:0046470; GO:0010694; GO:0043065; GO:0045919; GO:0010595; GO:0010907; GO:0010983; GO:0035774; GO:0051044; GO:0010867; GO:0005578; GO:1900076; GO:0009749; GO:0017080; GO:0070633 GPI anchor release; cell migration involved in sprouting angiogenesis; cellular response to calcium ion; cellular response to cholesterol; cellular response to drug; cellular response to pH; cellular response to triglyceride; chondrocyte differentiation; complement receptor mediated signaling pathway; cytoplasm; extracellular space; glycosylphosphatidylinositol phospholipase D activity; high-density lipoprotein particle; insulin receptor signaling pathway; intracellular membrane-bounded organelle; negative regulation of cell proliferation; negative regulation of triglyceride catabolic process; ossification; phosphatidylcholine metabolic process; positive regulation of alkaline phosphatase activity; positive regulation of apoptotic process; positive regulation of cytolysis; positive regulation of endothelial cell migration; positive regulation of glucose metabolic process; positive regulation of high-density lipoprotein particle clearance; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of membrane protein ectodomain proteolysis; positive regulation of triglyceride biosynthetic process; proteinaceous extracellular matrix; regulation of cellular response to insulin stimulus; response to glucose stimulus; sodium channel regulator activity; transepithelial transport IPR013517; IPR001028; IPR013519; Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycoprotein phospholipase D) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D) GPLD1 PIGPLD Bos taurus (Bovine) TR11890_c0_g1_i1 O76054 S14L2_HUMAN 2.00E-27 GO:0005737; GO:0016021; GO:0005634; GO:0005543; GO:0045893; GO:0045540; GO:0006351; GO:0005215; GO:0008431 "cytoplasm; integral to membrane; nucleus; phospholipid binding; positive regulation of transcription, DNA-dependent; regulation of cholesterol biosynthetic process; transcription, DNA-dependent; transporter activity; vitamin E binding" IPR001071; IPR001251; IPR011074; IPR009038; SEC14-like protein 2 (Alpha-tocopherol-associated protein) (TAP) (hTAP) (Squalene transfer protein) (Supernatant protein factor) (SPF) SEC14L2 C22orf6 KIAA1186 KIAA1658 Homo sapiens (Human) TR11893_c0_g1_i1 Q3UQ28 PXDN_MOUSE 5.00E-08 GO:0005783; GO:0031012; GO:0030198; GO:0005201; GO:0005615; GO:0020037; GO:0042744; GO:0046872; GO:0004601; GO:0005578 endoplasmic reticulum; extracellular matrix; extracellular matrix organization; extracellular matrix structural constituent; extracellular space; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity; proteinaceous extracellular matrix IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; IPR001007; Peroxidasin homolog (EC 1.11.1.7) Pxdn Kiaa0230 Mus musculus (Mouse) TR11894_c1_g1_i1 Q62059 CSPG2_MOUSE 8.00E-17 GO:0005509; GO:0030246; GO:0007155; GO:0007507; GO:0005540; GO:0005578; GO:0001657 calcium ion binding; carbohydrate binding; cell adhesion; heart development; hyaluronic acid binding; proteinaceous extracellular matrix; ureteric bud development IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Large fibroblast proteoglycan) (PG-M) Vcan Cspg2 Mus musculus (Mouse) TR11895_c2_g1_i1 O75751 S22A3_HUMAN 5.00E-09 GO:0005329; GO:0015872; GO:0006855; GO:0051615; GO:0005887; GO:0015651; GO:0032098; GO:0044281; GO:1901998; GO:0019534 P00519 dopamine transmembrane transporter activity; dopamine transport; drug transmembrane transport; histamine uptake; integral to plasma membrane; quaternary ammonium group transmembrane transporter activity; regulation of appetite; small molecule metabolic process; toxin transport; toxin transporter activity IPR011701; IPR020846; IPR016196; IPR004749; IPR005829; Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3) SLC22A3 EMTH OCT3 Homo sapiens (Human) TR11896_c0_g1_i1 P10606 COX5B_HUMAN 2.00E-20 GO:0004129; GO:0046872; GO:0005743; GO:0022904; GO:0007585; GO:0044281 cytochrome-c oxidase activity; metal ion binding; mitochondrial inner membrane; respiratory electron transport chain; respiratory gaseous exchange; small molecule metabolic process IPR002124; IPR020893; "Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb)" COX5B Homo sapiens (Human) TR11909_c1_g1_i1 Q8IYJ2 CJ067_HUMAN 8.00E-12 Uncharacterized protein C10orf67 C10orf67 Homo sapiens (Human) TR11919_c1_g1_i1 Q5REG4 DTX3_PONAB 7.00E-19 GO:0007219; GO:0005737; GO:0016874; GO:0016567; GO:0008270 Notch signaling pathway; cytoplasm; ligase activity; protein ubiquitination; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase DTX3 (EC 6.3.2.-) (Protein deltex-3) (Deltex3) DTX3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR11920_c0_g1_i1 P34727 ARF_AJECA 2.00E-24 GO:0005525; GO:0005794; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor ARF Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum) TR11926_c0_g1_i1 P13360 GLAS_DROME 2.00E-23 GO:0003677; GO:0003705; GO:0001752; GO:0043153; GO:0046872; GO:0005634; GO:0045944; GO:0010114; GO:0035271; GO:0007605; GO:0007601 DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; compound eye photoreceptor fate commitment; entrainment of circadian clock by photoperiod; metal ion binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; response to red light; ring gland development; sensory perception of sound; visual perception IPR007087; IPR015880; IPR013087; Protein glass gl CG7672 Drosophila melanogaster (Fruit fly) TR1194_c0_g1_i1 Q8C0L6 PAOX_MOUSE 4.00E-10 GO:0052899; GO:0052904; GO:0052903; GO:0005777; GO:0006598; GO:0046592; GO:0052902; GO:0008215; GO:0052901 "N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; peroxisome; polyamine catabolic process; polyamine oxidase activity; spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity; spermine metabolic process; spermine:oxygen oxidoreductase (spermidine-forming) activity" IPR002937; IPR016040; Amine and polyamine metabolism; spermine metabolism. Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC 1.5.3.13) (Polyamine oxidase) Paox Pao Mus musculus (Mouse) TR11948_c0_g1_i1 P41437 IAP3_NPVOP 9.00E-11 GO:0006915; GO:0016874; GO:0039648; GO:0008270 apoptotic process; ligase activity; modulation by virus of host protein ubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; E3 ubiquitin-protein ligase IAP-3 (EC 6.3.2.-) (IAP-3) IAP3 IAP ORF35 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) TR11956_c1_g2_i1 Q66KE9 F161A_XENLA 1.00E-31 GO:0030030; GO:0005929; GO:0005737; GO:0005932 cell projection organization; cilium; cytoplasm; microtubule basal body IPR019579; Protein FAM161A fam161a Xenopus laevis (African clawed frog) TR11972_c1_g1_i1 P49013 FBP3_STRPU 7.00E-26 GO:0005509; GO:0005615 calcium ion binding; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) TR11974_c0_g1_i1 B3P5D2 FOSL_DROER 6.00E-06 GO:0003677; GO:0009790; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "DNA binding; embryo development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; IPR000837; Transcription factor kayak kay GG11694 Drosophila erecta (Fruit fly) TR11976_c1_g1_i1 Q552Z6 GTPA_DICDI 4.00E-07 GO:0005525 GTP binding IPR006703; IPR027417; GTP-binding protein A gtpA DDB_G0275441 Dictyostelium discoideum (Slime mold) TR11980_c1_g1_i1 Q28GW8 MELK_XENTR 8.00E-57 GO:0005524; GO:0006915; GO:0005509; GO:0005938; GO:0007049; GO:0030097; GO:0008289; GO:0061351; GO:0004715; GO:0005886; GO:0043065; GO:0046777; GO:0004674 ATP binding; apoptotic process; calcium ion binding; cell cortex; cell cycle; hemopoiesis; lipid binding; neural precursor cell proliferation; non-membrane spanning protein tyrosine kinase activity; plasma membrane; positive regulation of apoptotic process; protein autophosphorylation; protein serine/threonine kinase activity IPR028375; IPR001772; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Maternal embryonic leucine zipper kinase (EC 2.7.11.1) melk TEgg058f04.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR11980_c2_g1_i1 Q7RX99 ATG1_NEUCR 3.00E-07 GO:0005524; GO:0006914; GO:0034045; GO:0004674; GO:0015031 ATP binding; autophagy; pre-autophagosomal structure membrane; protein serine/threonine kinase activity; protein transport IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR022708; Serine/threonine-protein kinase atg-1 (EC 2.7.11.1) (Autophagy-related protein 1) atg-1 NCU00188 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR11988_c0_g1_i1 Q8N9F8 ZN454_HUMAN 7.00E-12 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 454 ZNF454 Homo sapiens (Human) TR11988_c0_g2_i1 Q8TBZ5 ZN502_HUMAN 7.00E-10 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 502 ZNF502 Homo sapiens (Human) TR11988_c1_g1_i1 Q6P2D0 ZFP1_HUMAN 1.00E-28 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 1 homolog (Zfp-1) (Zinc finger protein 475) ZFP1 ZNF475 Homo sapiens (Human) TR11998_c1_g1_i1 P82596 PLC_HALLA 2.00E-07 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR12001_c0_g1_i1 Q6NY15 TSG10_MOUSE 8.00E-17 GO:0030031; GO:0005737; GO:0031514; GO:0043005; GO:0031965; GO:0005198 Q61221-1 cell projection assembly; cytoplasm; motile cilium; neuron projection; nuclear membrane; structural molecule activity Testis-specific gene 10 protein Tsga10 Mus musculus (Mouse) TR12002_c0_g1_i1 Q0V8L6 PLD2_BOVIN 4.00E-17 GO:0070290; GO:0007154; GO:0016042; GO:0016020; GO:0035091; GO:0004630 NAPE-specific phospholipase D activity; cell communication; lipid catabolic process; membrane; phosphatidylinositol binding; phospholipase D activity IPR011993; IPR001683; IPR025202; IPR001849; IPR001736; IPR016555; IPR015679; Phospholipase D2 (PLD 2) (EC 3.1.4.4) (Choline phosphatase 2) (Phosphatidylcholine-hydrolyzing phospholipase D2) PLD2 Bos taurus (Bovine) TR12005_c2_g1_i1 Q28062 PGCB_BOVIN 7.00E-13 GO:0030246; GO:0007155; GO:0005540; GO:0005578 carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR007110; IPR013783; IPR003006; IPR013106; IPR003596; IPR000538; IPR000436; Brevican core protein BCAN Bos taurus (Bovine) TR12005_c4_g1_i1 Q9JI18 LRP1B_MOUSE 3.00E-22 GO:0005509; GO:0016021; GO:0050750; GO:0005041; GO:0016020 Q9WVI9-1; Q80VC8; P69566 calcium ion binding; integral to membrane; low-density lipoprotein particle receptor binding; low-density lipoprotein receptor activity; membrane IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) Lrp1b Lrpdit Mus musculus (Mouse) TR12005_c5_g1_i1 Q9H5Y7 SLIK6_HUMAN 4.00E-08 GO:0007409; GO:0016021 axonogenesis; integral to membrane IPR000483; IPR001611; IPR003591; SLIT and NTRK-like protein 6 SLITRK6 Homo sapiens (Human) TR12014_c1_g1_i1 Q0VBL6 HIF3A_MOUSE 2.00E-11 GO:0003677; GO:0005737; GO:0005634; GO:0001666; GO:0003700; GO:0004871; GO:0006366 DNA binding; cytoplasm; nucleus; response to hypoxia; sequence-specific DNA binding transcription factor activity; signal transducer activity; transcription from RNA polymerase II promoter IPR011598; IPR021537; IPR001610; IPR000014; IPR013767; Hypoxia-inducible factor 3-alpha (HIF-3-alpha) (HIF3-alpha) (Basic-helix-loop-helix-PAS protein MOP7) (HIF3-alpha-1) (Inhibitory PAS domain protein) (IPAS) (Member of PAS protein 7) Hif3a Mop7 Mus musculus (Mouse) TR12023_c0_g1_i1 A4IIK1 MFHA1_XENTR 7.00E-12 GO:0005525; GO:0007264 GTP binding; small GTPase mediated signal transduction IPR001611; IPR025875; IPR003591; IPR027417; IPR020859; IPR001806; Malignant fibrous histiocytoma-amplified sequence 1 homolog mfhas1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR12023_c1_g1_i1 Q6INV3 LRC57_XENLA 3.00E-09 IPR001611; IPR025875; IPR003591; Leucine-rich repeat-containing protein 57 lrrc57 Xenopus laevis (African clawed frog) TR12029_c0_g1_i1 Q7L266 ASGL1_HUMAN 2.00E-35 GO:0004067; GO:0033345; GO:0008798; GO:0005737; GO:0015630; GO:0005634; GO:0006508 asparaginase activity; asparagine catabolic process via L-aspartate; beta-aspartyl-peptidase activity; cytoplasm; microtubule cytoskeleton; nucleus; proteolysis IPR000246; Isoaspartyl peptidase/L-asparaginase (EC 3.4.19.5) (EC 3.5.1.1) (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain] ASRGL1 ALP CRASH Homo sapiens (Human) TR12029_c0_g2_i1 Q5JHT1 ASGX_PYRKO 2.00E-36 GO:0004067; GO:0008233; GO:0006508 asparaginase activity; peptidase activity; proteolysis IPR000246; Putative L-asparaginase (EC 3.5.1.1) (L-asparagine amidohydrolase) [Cleaved into: Putative L-asparaginase subunit alpha; Putative L-asparaginase subunit beta] TK2246 Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) TR12029_c1_g1_i1 Q29I93 ASGL1_DROPS 4.00E-24 GO:0003948; GO:0004067; GO:0033345; GO:0008798; GO:0005737; GO:0006508 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity; asparaginase activity; asparagine catabolic process via L-aspartate; beta-aspartyl-peptidase activity; cytoplasm; proteolysis IPR000246; Probable isoaspartyl peptidase/L-asparaginase GA20639 (EC 3.4.19.5) (EC 3.5.1.1) (Beta-aspartyl-peptidase GA20639) (Isoaspartyl dipeptidase GA20639) (L-asparagine amidohydrolase GA20639) [Cleaved into: Probable isoaspartyl peptidase/L-asparaginase GA20639 alpha chain; Probable isoaspartyl peptidase/L-asparaginase GA20639 beta chain] GA20639 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR12032_c1_g1_i1 Q8R0M8 MOT5_MOUSE 1.00E-10 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 5 (MCT 5) Slc16a4 Mct5 Mus musculus (Mouse) TR12032_c1_g2_i1 O15374 MOT5_HUMAN 8.00E-10 GO:0005887; GO:0008028; GO:0015293 integral to plasma membrane; monocarboxylic acid transmembrane transporter activity; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 5 (MCT 5) (Monocarboxylate transporter 4) (MCT 4) (Solute carrier family 16 member 4) SLC16A4 MCT4 MCT5 Homo sapiens (Human) TR12038_c0_g1_i1 Q27319 GELS_HOMAM 9.00E-15 GO:0051693; GO:0005737; GO:0005856; GO:0046872 actin filament capping; cytoplasm; cytoskeleton; metal ion binding IPR007123; IPR007122; "Gelsolin, cytoplasmic (Actin-depolymerizing factor) (ADF)" Homarus americanus (American lobster) TR12042_c0_g1_i1 Q6GMI7 ENOPH_DANRE 5.00E-35 GO:0019509; GO:0043874; GO:0005737; GO:0000287; GO:0005634 L-methionine salvage from methylthioadenosine; acireductone synthase activity; cytoplasm; magnesium ion binding; nucleus IPR023943; IPR027511; IPR023214; IPR006439; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6. Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6. "Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase) (MASA homolog)" enoph1 masa zgc:91991 Danio rerio (Zebrafish) (Brachydanio rerio) TR12056_c0_g1_i1 Q9NTG7 SIR3_HUMAN 2.00E-27 GO:0003950; GO:0070403; GO:0032041; GO:0009060; GO:0016020; GO:0005759; GO:0005739; GO:0034983; GO:0006471; GO:0008270 P25705; Q13309 NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity (H3-K14 specific); aerobic respiration; membrane; mitochondrial matrix; mitochondrion; peptidyl-lysine deacetylation; protein ADP-ribosylation; zinc ion binding IPR017328; IPR003000; IPR026591; IPR026590; "NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 3.5.1.-) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3)" SIRT3 SIR2L3 Homo sapiens (Human) TR12085_c0_g1_i1 Q13946 PDE7A_HUMAN 2.00E-09 GO:0004115; GO:0006198; GO:0005829; GO:0046872; GO:0007165 "3',5'-cyclic-AMP phosphodiesterase activity; cAMP catabolic process; cytosol; metal ion binding; signal transduction" IPR003607; IPR023088; IPR002073; IPR023174; "Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1." "High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.53) (HCP1) (TM22)" PDE7A Homo sapiens (Human) TR1209_c0_g1_i1 Q27274 RO60_CAEEL 7.00E-17 GO:0003723; GO:0005737; GO:0046872; GO:0030529 RNA binding; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein homolog rop-1 C12D8.11 Caenorhabditis elegans TR12095_c0_g1_i1 Q28480 IDH3A_MACFA 7.00E-44 GO:0051287; GO:0004449; GO:0000287; GO:0005739; GO:0006099 NAD binding; isocitrate dehydrogenase (NAD+) activity; magnesium ion binding; mitochondrion; tricarboxylic acid cycle IPR019818; IPR001804; IPR004434; IPR024084; "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha) (Fragment)" IDH3A Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR12095_c1_g1_i1 P28834 IDH1_YEAST 6.00E-11 GO:0051287; GO:0003723; GO:0005829; GO:0006537; GO:0004449; GO:0006102; GO:0000287; GO:0005758; GO:0005962; GO:0042645; GO:0006099 P28241 NAD binding; RNA binding; cytosol; glutamate biosynthetic process; isocitrate dehydrogenase (NAD+) activity; isocitrate metabolic process; magnesium ion binding; mitochondrial intermembrane space; mitochondrial isocitrate dehydrogenase complex (NAD+); mitochondrial nucleoid; tricarboxylic acid cycle IPR019818; IPR001804; IPR004434; IPR024084; "Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase) (NAD(+)-specific ICDH)" IDH1 YNL037C N2690 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR12099_c0_g1_i1 P56719 OX2R_RAT 8.00E-06 GO:0022410; GO:0007631; GO:0016021; GO:0007218; GO:0016499; GO:0017046; GO:0007200; GO:0005886 circadian sleep/wake cycle process; feeding behavior; integral to membrane; neuropeptide signaling pathway; orexin receptor activity; peptide hormone binding; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane IPR000276; IPR017452; IPR000204; IPR004060; Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Rattus norvegicus (Rat) TR12104_c1_g1_i1 O19183 PGH2_HORSE 7.00E-139 GO:0042640; GO:0050873; GO:0071456; GO:0019371; GO:0005737; GO:0051213; GO:0005789; GO:0020037; GO:0046872; GO:0043005; GO:0005634; GO:0004601; GO:0090336; GO:0031622; GO:0004666; GO:0008217; GO:0042127; GO:0006979 anagen; brown fat cell differentiation; cellular response to hypoxia; cyclooxygenase pathway; cytoplasm; dioxygenase activity; endoplasmic reticulum membrane; heme binding; metal ion binding; neuron projection; nucleus; peroxidase activity; positive regulation of brown fat cell differentiation; positive regulation of fever generation; prostaglandin-endoperoxide synthase activity; regulation of blood pressure; regulation of cell proliferation; response to oxidative stress IPR000742; IPR010255; IPR002007; IPR019791; Lipid metabolism; prostaglandin biosynthesis. Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) PTGS2 COX2 Equus caballus (Horse) TR12108_c1_g1_i1 A2AV25 FBCD1_MOUSE 2.00E-23 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 Fibcd1 Mus musculus (Mouse) TR12111_c0_g1_i1 Q6ZNA5 FRRS1_HUMAN 1.00E-10 GO:0000293; GO:0016021; GO:0046872 ferric-chelate reductase activity; integral to membrane; metal ion binding IPR006593; IPR005018; IPR002861; Ferric-chelate reductase 1 (EC 1.-.-.-) (Stromal cell-derived receptor 2) (SDR-2) FRRS1 SDFR2 SDR2 Homo sapiens (Human) TR12126_c0_g1_i1 P49746 TSP3_HUMAN 4.00E-26 GO:0060346; GO:0005509; GO:0007160; GO:0005576; GO:0003417; GO:0008201; GO:0043931; GO:0048471 bone trabecula formation; calcium ion binding; cell-matrix adhesion; extracellular region; growth plate cartilage development; heparin binding; ossification involved in bone maturation; perinuclear region of cytoplasm IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR018097; IPR001791; IPR024665; IPR003367; IPR017897; IPR008859; Thrombospondin-3 THBS3 TSP3 Homo sapiens (Human) TR12126_c1_g1_i1 Q8JGW0 TSP4B_DANRE 1.00E-17 GO:0005509; GO:0016337; GO:0007160; GO:0031012; GO:0005615; GO:0008201; GO:0051781; GO:0016529 calcium ion binding; cell-cell adhesion; cell-matrix adhesion; extracellular matrix; extracellular space; heparin binding; positive regulation of cell division; sarcoplasmic reticulum IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR018097; IPR001791; IPR024665; IPR003367; IPR017897; IPR008859; Thrombospondin-4-B (Thbs4-B) thbs4b thbs4 tsp4 Danio rerio (Zebrafish) (Brachydanio rerio) TR12126_c3_g1_i1 Q61220 NELL2_MOUSE 2.00E-09 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR009030; IPR001791; IPR001007; Protein kinase C-binding protein NELL2 (MEL91 protein) (NEL-like protein 2) Nell2 Mel91 Mus musculus (Mouse) TR12126_c5_g1_i1 Q03350 TSP2_MOUSE 3.00E-14 GO:0005604; GO:0005509; GO:0007155; GO:0008201; GO:0016525 Q63722; Q07954 basement membrane; calcium ion binding; cell adhesion; heparin binding; negative regulation of angiogenesis IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR024731; IPR001791; IPR000884; IPR015455; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-2 Thbs2 Tsp2 Mus musculus (Mouse) TR12127_c1_g1_i1 P35738 ODBB_RAT 7.00E-54 GO:0003863; GO:0003826; GO:0009083; GO:0005947; GO:0051591; GO:0051384; GO:0007584 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity; alpha-ketoacid dehydrogenase activity; branched-chain amino acid catabolic process; mitochondrial alpha-ketoglutarate dehydrogenase complex; response to cAMP; response to glucocorticoid stimulus; response to nutrient IPR009014; IPR005475; IPR005476; "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDE1B) (BCKDH E1-beta)" Bckdhb Rattus norvegicus (Rat) TR1214_c0_g1_i1 Q9P2K1 C2D2A_HUMAN 2.00E-46 GO:0036038; GO:0042384; GO:0005737; GO:0005932; GO:0007224 TCTN-B9D complex; cilium assembly; cytoplasm; microtubule basal body; smoothened signaling pathway IPR000008; Coiled-coil and C2 domain-containing protein 2A CC2D2A KIAA1345 Homo sapiens (Human) TR12151_c1_g1_i1 Q9QUM9 PSA6_MOUSE 7.00E-70 GO:0003723; GO:0000932; GO:0005829; GO:0016363; GO:0005844; GO:0051092; GO:0019773; GO:0051603; GO:0030017; GO:0007519; GO:0004298; GO:0006511 "RNA binding; cytoplasmic mRNA processing body; cytosol; nuclear matrix; polysome; positive regulation of NF-kappaB transcription factor activity; proteasome core complex, alpha-subunit complex; proteolysis involved in cellular protein catabolic process; sarcomere; skeletal muscle tissue development; threonine-type endopeptidase activity; ubiquitin-dependent protein catabolic process" IPR000426; IPR023332; IPR001353; Proteasome subunit alpha type-6 (EC 3.4.25.1) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain) Psma6 Mus musculus (Mouse) TR12152_c0_g1_i1 Q54F46 WARA_DICDI 2.00E-13 GO:0009653; GO:0007275; GO:0005634; GO:0045595; GO:0043565; GO:0003700; GO:0006351 "anatomical structure morphogenesis; multicellular organismal development; nucleus; regulation of cell differentiation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR002110; IPR020683; IPR017970; IPR001356; IPR009057; Homeobox protein Wariai (Homeobox protein 1) (DdHbx-1) warA hbx1 wri DDB_G0291075 Dictyostelium discoideum (Slime mold) TR1216_c0_g1_i1 A5A8Y8 EGFL8_PIG 3.00E-06 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR011489; IPR009030; Epidermal growth factor-like protein 8 (EGF-like protein 8) EGFL8 Sus scrofa (Pig) TR12161_c0_g1_i1 Q53H47 SETMR_HUMAN 2.00E-10 GO:0000737; GO:0000729; GO:0015074; GO:0005694; GO:0004519; GO:0018024; GO:0071157; GO:2001251; GO:0005634; GO:2001034; GO:0043566; GO:0004803; GO:0006313; GO:0008270 "DNA catabolic process, endonucleolytic; DNA double-strand break processing; DNA integration; chromosome; endonuclease activity; histone-lysine N-methyltransferase activity; negative regulation of cell cycle arrest; negative regulation of chromosome organization; nucleus; positive regulation of double-strand break repair via nonhomologous end joining; structure-specific DNA binding; transposase activity; transposition, DNA-mediated; zinc ion binding" IPR003616; IPR007728; IPR003606; IPR001214; IPR001888; IPR002492; Histone-lysine N-methyltransferase SETMAR (SET domain and mariner transposase fusion gene-containing protein) (HsMar1) (Metnase) [Includes: Histone-lysine N-methyltransferase (EC 2.1.1.43); Mariner transposase Hsmar1 (EC 3.1.-.-)] SETMAR Homo sapiens (Human) TR12169_c0_g1_i1 O96790 DPGN_DIPMA 8.00E-13 GO:0005576; GO:0050819; GO:0004867 extracellular region; negative regulation of coagulation; serine-type endopeptidase inhibitor activity IPR002350; Serine protease inhibitor dipetalogastin (Dipetalin) (Fragment) Dipetalogaster maximus (Blood-sucking bug) TR12177_c0_g1_i1 Q8R151 ZNFX1_MOUSE 4.00E-22 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR12182_c1_g1_i1 Q2KJE4 ETFA_BOVIN 1.00E-30 GO:0009055; GO:0050660; GO:0005759; GO:0055114 electron carrier activity; flavin adenine dinucleotide binding; mitochondrial matrix; oxidation-reduction process IPR001308; IPR014730; IPR014731; IPR018206; IPR014729; "Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF)" ETFA Bos taurus (Bovine) TR12191_c0_g1_i1 Q4KL91 S36A4_XENLA 2.00E-33 GO:0006865; GO:0016021; GO:0015293 amino acid transport; integral to membrane; symporter activity IPR013057; Proton-coupled amino acid transporter 4 (Proton/amino acid transporter 4) (Solute carrier family 36 member 4) slc36a4 pat4 Xenopus laevis (African clawed frog) TR12201_c1_g1_i1 Q0VA42 F188B_XENTR 2.00E-28 IPR025257; Protein FAM188B fam188b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR12201_c2_g1_i1 Q5RF72 F188B_PONAB 6.00E-31 IPR025257; Protein FAM188B FAM188B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR12202_c2_g1_i1 P82596 PLC_HALLA 4.00E-16 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR12205_c0_g1_i2 Q9DBE0 CSAD_MOUSE 2.00E-25 GO:0019452; GO:0016831; GO:0030170; GO:0004782; GO:0042412 L-cysteine catabolic process to taurine; carboxy-lyase activity; pyridoxal phosphate binding; sulfinoalanine decarboxylase activity; taurine biosynthetic process IPR002129; IPR015424; IPR015421; IPR015422; IPR021115; Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 2/2. Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase) Csad Mus musculus (Mouse) TR12207_c0_g1_i1 Q9SXE1 GSOX3_ARATH 2.00E-10 GO:0080102; GO:0080103; GO:0080104; GO:0080105; GO:0080106; GO:0080107; GO:0004499; GO:0050661; GO:0050660; GO:0019761; GO:0016021 "3-methylthiopropyl glucosinolate S-oxygenase activity; 4-methylthiopropyl glucosinolate S-oxygenase activity; 5-methylthiopropyl glucosinolate S-oxygenase activity; 6-methylthiopropyl glucosinolate S-oxygenase activity; 7-methylthiopropyl glucosinolate S-oxygenase activity; 8-methylthiopropyl glucosinolate S-oxygenase activity; N,N-dimethylaniline monooxygenase activity; NADP binding; flavin adenine dinucleotide binding; glucosinolate biosynthetic process; integral to membrane" IPR000960; IPR020946; Flavin-containing monooxygenase FMO GS-OX3 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase 3) FMOGS-OX3 At1g62560 T3P18.12 Arabidopsis thaliana (Mouse-ear cress) TR12207_c3_g1_i1 P97872 FMO5_MOUSE 4.00E-27 GO:0004499; GO:0050661; GO:0005789; GO:0050660; GO:0016021 "N,N-dimethylaniline monooxygenase activity; NADP binding; endoplasmic reticulum membrane; flavin adenine dinucleotide binding; integral to membrane" IPR012143; IPR000960; IPR020946; IPR002257; IPR016040; Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5) Fmo5 Mus musculus (Mouse) TR12207_c4_g1_i1 P17635 FMO2_RABIT 4.00E-30 GO:0004499; GO:0050661; GO:0070995; GO:0005789; GO:0050660; GO:0016021; GO:0016020 "N,N-dimethylaniline monooxygenase activity; NADP binding; NADPH oxidation; endoplasmic reticulum membrane; flavin adenine dinucleotide binding; integral to membrane; membrane" IPR012143; IPR000960; IPR020946; IPR002254; IPR016040; Dimethylaniline monooxygenase [N-oxide-forming] 2 (EC 1.14.13.8) (Dimethylaniline oxidase 2) (FMO 1B1) (Pulmonary flavin-containing monooxygenase 2) (FMO 2) FMO2 Oryctolagus cuniculus (Rabbit) TR12211_c0_g1_i1 Q6GQD1 CYFP2_XENLA 3.00E-37 GO:0006915; GO:0007155; GO:0005737 apoptotic process; cell adhesion; cytoplasm IPR008081; IPR016536; Cytoplasmic FMR1-interacting protein 2 cyfip2 Xenopus laevis (African clawed frog) TR12219_c0_g1_i1 P20825 POL2_DROME 7.00E-18 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR12227_c0_g1_i1 P24821 TENA_HUMAN 3.00E-27 GO:0005604; GO:0007155; GO:0030198; GO:0005615; GO:0005614; GO:0060739; GO:0007528; GO:0014012; GO:0008284; GO:0010628; GO:0060740; GO:0009611 basement membrane; cell adhesion; extracellular matrix organization; extracellular space; interstitial matrix; mesenchymal-epithelial cell signaling involved in prostate gland development; neuromuscular junction development; peripheral nervous system axon regeneration; positive regulation of cell proliferation; positive regulation of gene expression; prostate gland epithelium morphogenesis; response to wounding IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) TNC HXB Homo sapiens (Human) TR12237_c0_g1_i1 O43181 NDUS4_HUMAN 1.00E-39 GO:0008137; GO:0007420; GO:0019933; GO:0006120; GO:0005747; GO:0032981; GO:0048146; GO:0072593; GO:0001932; GO:0051591; GO:0044281 "NADH dehydrogenase (ubiquinone) activity; brain development; cAMP-mediated signaling; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I; mitochondrial respiratory chain complex I assembly; positive regulation of fibroblast proliferation; reactive oxygen species metabolic process; regulation of protein phosphorylation; response to cAMP; small molecule metabolic process" IPR006885; "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (CI-18 kDa) (Complex I-AQDQ) (CI-AQDQ) (NADH-ubiquinone oxidoreductase 18 kDa subunit)" NDUFS4 Homo sapiens (Human) TR12240_c0_g1_i1 Q8IYW2 TTC40_HUMAN 2.00E-31 IPR011990; Tetratricopeptide repeat protein 40 TTC40 C10orf123 C10orf124 C10orf92 C10orf93 Homo sapiens (Human) TR12245_c1_g2_i1 Q8CC12 CDAN1_MOUSE 5.00E-43 GO:0031497; GO:0005737; GO:0016021; GO:0008156; GO:0005634 chromatin assembly; cytoplasm; integral to membrane; negative regulation of DNA replication; nucleus IPR028171; Codanin-1 Cdan1 Mus musculus (Mouse) TR12245_c2_g1_i1 Q8T626 DLT_DROME 5.00E-21 GO:0005737; GO:0007560; GO:0046331; GO:0001738; GO:0042048; GO:0042127 cytoplasm; imaginal disc morphogenesis; lateral inhibition; morphogenesis of a polarized epithelium; olfactory behavior; regulation of cell proliferation IPR028171; Protein disks lost (Codanin 1 homolog) (Protein vanaso) dlt VA CG32315 Drosophila melanogaster (Fruit fly) TR12248_c2_g1_i1 P0CY46 EGFR_APIME 6.00E-59 GO:0005524; GO:0016021; GO:0007275; GO:0018108; GO:0004714; GO:0007169 ATP binding; integral to membrane; multicellular organismal development; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000494; IPR006211; IPR006212; IPR009030; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Epidermal growth factor receptor (Egfr) (EC 2.7.10.1) Egfr Apis mellifera (Honeybee) TR1225_c0_g1_i1 Q99572 P2RX7_HUMAN 5.00E-12 GO:0005524; GO:0043132; GO:0043029; GO:0042098; GO:0000187; GO:0097190; GO:0032059; GO:0032060; GO:0000902; GO:0006884; GO:0005911; GO:0031668; GO:0046513; GO:0032963; GO:0005507; GO:0019835; GO:0005737; GO:0050830; GO:0009897; GO:0004931; GO:0048873; GO:0006954; GO:0045087; GO:0005639; GO:0005887; GO:0001530; GO:0000287; GO:0006900; GO:0051899; GO:0006509; GO:0045121; GO:0007005; GO:0044254; GO:0043409; GO:0045779; GO:0031594; GO:0043025; GO:0035872; GO:0001845; GO:0006649; GO:0045332; GO:0007009; GO:0046931; GO:0001916; GO:0043065; GO:0030501; GO:0010524; GO:0045919; GO:0051495; GO:0014054; GO:0014049; GO:0050717; GO:0050718; GO:0032755; GO:0051901; GO:0032308; GO:0043234; GO:0042803; GO:0051259; GO:0006468; GO:0016485; GO:0001614; GO:0072593; GO:0005102; GO:0019228; GO:0051709; GO:0002028; GO:0051209; GO:0033198; GO:0051592; GO:0042493; GO:0051602; GO:0034405; GO:0032496; GO:0009612; GO:0010043; GO:0019233; GO:0048705; GO:0016079; GO:0043195; GO:0008270 P00519; P62993; P16333 "ATP binding; NAD transport; T cell homeostasis; T cell proliferation; activation of MAPK activity; apoptotic signaling pathway; bleb; bleb assembly; cell morphogenesis; cell volume homeostasis; cell-cell junction; cellular response to extracellular stimulus; ceramide biosynthetic process; collagen metabolic process; copper ion binding; cytolysis; cytoplasm; defense response to Gram-positive bacterium; external side of plasma membrane; extracellular ATP-gated cation channel activity; homeostasis of number of cells within a tissue; inflammatory response; innate immune response; integral to nuclear inner membrane; integral to plasma membrane; lipopolysaccharide binding; magnesium ion binding; membrane budding; membrane depolarization; membrane protein ectodomain proteolysis; membrane raft; mitochondrion organization; multicellular organismal protein catabolic process; negative regulation of MAPK cascade; negative regulation of bone resorption; neuromuscular junction; neuronal cell body; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; phagolysosome assembly; phospholipid transfer to membrane; phospholipid translocation; plasma membrane organization; pore complex assembly; positive regulation of T cell mediated cytotoxicity; positive regulation of apoptotic process; positive regulation of bone mineralization; positive regulation of calcium ion transport into cytosol; positive regulation of cytolysis; positive regulation of cytoskeleton organization; positive regulation of gamma-aminobutyric acid secretion; positive regulation of glutamate secretion; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 production; positive regulation of mitochondrial depolarization; positive regulation of prostaglandin secretion; protein complex; protein homodimerization activity; protein oligomerization; protein phosphorylation; protein processing; purinergic nucleotide receptor activity; reactive oxygen species metabolic process; receptor binding; regulation of action potential in neuron; regulation of killing of cells of other organism; regulation of sodium ion transport; release of sequestered calcium ion into cytosol; response to ATP; response to calcium ion; response to drug; response to electrical stimulus; response to fluid shear stress; response to lipopolysaccharide; response to mechanical stimulus; response to zinc ion; sensory perception of pain; skeletal system morphogenesis; synaptic vesicle exocytosis; terminal bouton; zinc ion binding" IPR003050; IPR027309; IPR001429; P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2RX7 Homo sapiens (Human) TR12251_c0_g1_i1 Q8N6D5 ANR29_HUMAN 8.00E-13 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 29 ANKRD29 Homo sapiens (Human) TR12262_c0_g1_i1 O75382 TRIM3_HUMAN 3.00E-11 GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0015031; GO:0008270 cytoplasm; early endosome; nervous system development; protein C-terminus binding; protein transport; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) TR12273_c0_g2_i1 Q1XG90 LYS2_CRAVI 8.00E-33 GO:0019835; GO:0042742; GO:0005576; GO:0003796 cytolysis; defense response to bacterium; extracellular region; lysozyme activity IPR008597; IPR023346; "Lysozyme 2 (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase 2) (cv-lysozyme 2)" lysoz2 Crassostrea virginica (Eastern oyster) TR12280_c1_g1_i1 Q03669 AT2A2_CHICK 1.00E-40 GO:0005524; GO:0006984; GO:0005388; GO:0006874; GO:0016021; GO:0046872; GO:0045822; GO:0002026; GO:0042493; GO:0016529; GO:0033017 ATP binding; ER-nucleus signaling pathway; calcium-transporting ATPase activity; cellular calcium ion homeostasis; integral to membrane; metal ion binding; negative regulation of heart contraction; regulation of the force of heart contraction; response to drug; sarcoplasmic reticulum; sarcoplasmic reticulum membrane IPR005782; IPR006068; IPR004014; IPR023299; IPR018303; IPR023298; IPR008250; IPR001757; IPR023214; "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 3.6.3.8) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)" ATP2A2 Gallus gallus (Chicken) TR12290_c1_g1_i1 P35246 SFTPD_BOVIN 9.00E-06 GO:0030246; GO:0005581; GO:0005615; GO:0048286; GO:0007585; GO:0043129 carbohydrate binding; collagen; extracellular space; lung alveolus development; respiratory gaseous exchange; surfactant homeostasis IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; IPR015097; Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (Lung surfactant protein D) SFTPD SFTP4 Bos taurus (Bovine) TR12291_c0_g1_i1 P10394 POL4_DROME 6.00E-06 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR12307_c0_g1_i1 A2RUS2 DEND3_HUMAN 4.00E-07 GO:0017112; GO:0044257; GO:0008333 Rab guanyl-nucleotide exchange factor activity; cellular protein catabolic process; endosome to lysosome transport IPR005112; IPR001194; IPR005113; IPR015943; IPR001680; IPR019775; IPR017986; DENN domain-containing protein 3 DENND3 KIAA0870 Homo sapiens (Human) TR12317_c0_g1_i1 Q14517 FAT1_HUMAN 5.00E-09 GO:0007015; GO:0009653; GO:0005509; GO:0016477; GO:0016337; GO:0005911; GO:0007267; GO:0007163; GO:0030175; GO:0007156; GO:0005887; GO:0030027; GO:0005634; GO:0048471 Q8N8S7; Q9NSC5; Q99JP6 actin filament organization; anatomical structure morphogenesis; calcium ion binding; cell migration; cell-cell adhesion; cell-cell junction; cell-cell signaling; establishment or maintenance of cell polarity; filopodium; homophilic cell adhesion; integral to plasma membrane; lamellipodium; nucleus; perinuclear region of cytoplasm IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) TR12320_c0_g1_i1 P18718 ZG3_XENLA 5.00E-18 GO:0003677; GO:0046872; GO:0005634 DNA binding; metal ion binding; nucleus IPR007087; IPR015880; IPR013087; Gastrula zinc finger protein xLCGF3.1 (Fragment) Xenopus laevis (African clawed frog) TR12331_c0_g1_i1 Q6DK72 SUMO3_XENTR 3.00E-35 GO:0005737; GO:0005634; GO:0016925 cytoplasm; nucleus; protein sumoylation IPR022617; IPR027218; IPR000626; Small ubiquitin-related modifier 3 (SUMO-3) sumo3 TEgg028f07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR12333_c0_g1_i1 P05205 HP1_DROME 2.00E-18 GO:0044026; GO:0005721; GO:0003682; GO:0030702; GO:0000780; GO:0006343; GO:0034773; GO:0042393; GO:0003729; GO:0022008; GO:0005720; GO:0005704; GO:0005701; GO:0005703; GO:0035012; GO:0045893; GO:0000182; GO:0042981; GO:0031060; GO:0003696; GO:0000723; GO:0006351 Q9W0Z5; Q95RV2; Q9VIE6 "DNA hypermethylation; centromeric heterochromatin; chromatin binding; chromatin silencing at centromere; condensed nuclear chromosome, centromeric region; establishment of chromatin silencing; histone H4-K20 trimethylation; histone binding; mRNA binding; neurogenesis; nuclear heterochromatin; polytene chromosome band; polytene chromosome chromocenter; polytene chromosome puff; polytene chromosome, telomeric region; positive regulation of transcription, DNA-dependent; rDNA binding; regulation of apoptotic process; regulation of histone methylation; satellite DNA binding; telomere maintenance; transcription, DNA-dependent" IPR017984; IPR023780; IPR000953; IPR008251; IPR016197; IPR023779; Heterochromatin protein 1 (HP1) (Non-histone chromosomal protein C1A9 antigen) Su(var)205 HP1 CG8409 Drosophila melanogaster (Fruit fly) TR12341_c0_g1_i1 P62914 RL11_RAT 4.00E-108 GO:0022625; GO:0005730; GO:0034504; GO:0006605; GO:0019843; GO:0006364; GO:0042273; GO:0003735; GO:0006412 cytosolic large ribosomal subunit; nucleolus; protein localization to nucleus; protein targeting; rRNA binding; rRNA processing; ribosomal large subunit biogenesis; structural constituent of ribosome; translation IPR002132; IPR020929; IPR022803; 60S ribosomal protein L11 Rpl11 Rattus norvegicus (Rat) TR12345_c0_g1_i1 Q17551 RPM1_CAEEL 3.00E-06 GO:0030424; GO:0010171; GO:0040011; GO:0043409; GO:0031594; GO:0005634; GO:0018991; GO:0036062; GO:0031647; GO:0050807; GO:0006355; GO:0006351; GO:0004842; GO:0008270 "axon; body morphogenesis; locomotion; negative regulation of MAPK cascade; neuromuscular junction; nucleus; oviposition; presynaptic periactive zone; regulation of protein stability; regulation of synapse organization; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR004939; IPR008979; IPR027047; IPR012983; IPR009091; IPR000408; IPR000315; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase rpm-1 (EC 6.3.2.-) (Pam/highwire/rpm-1 protein) (Regulator of presynaptic morphology protein 1) (Synapse defective protein 3) rpm-1 syd-3 C01B7.6 Caenorhabditis elegans TR12345_c3_g1_i1 Q13263 TIF1B_HUMAN 6.00E-06 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR12349_c0_g1_i1 Q29RQ3 DC1I1_BOVIN 9.00E-80 GO:0000777; GO:0005868; GO:0005874; GO:0007018; GO:0003774; GO:0000922; GO:0006810; GO:0031982 condensed chromosome kinetochore; cytoplasmic dynein complex; microtubule; microtubule-based movement; motor activity; spindle pole; transport; vesicle IPR025956; IPR015943; IPR001680; IPR017986; "Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1)" DYNC1I1 Bos taurus (Bovine) TR12351_c0_g1_i1 O00358 FOXE1_HUMAN 6.00E-13 GO:0008301; GO:0003705; GO:0016477; GO:0003690; GO:0048562; GO:0031069; GO:0060022; GO:0002089; GO:0000122; GO:0005634; GO:0007389; GO:0060465; GO:0045893; GO:0051090; GO:0043565; GO:0060023; GO:0048538; GO:0030878; GO:0006590; GO:0008134; GO:0005667 "DNA binding, bending; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; cell migration; double-stranded DNA binding; embryonic organ morphogenesis; hair follicle morphogenesis; hard palate development; lens morphogenesis in camera-type eye; negative regulation of transcription from RNA polymerase II promoter; nucleus; pattern specification process; pharynx development; positive regulation of transcription, DNA-dependent; regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; soft palate development; thymus development; thyroid gland development; thyroid hormone generation; transcription factor binding; transcription factor complex" IPR001766; IPR018122; IPR011991; Forkhead box protein E1 (Forkhead box protein E2) (Forkhead-related protein FKHL15) (HFKH4) (HNF-3/fork head-like protein 5) (HFKL5) (Thyroid transcription factor 2) (TTF-2) FOXE1 FKHL15 FOXE2 TITF2 TTF2 Homo sapiens (Human) TR12353_c1_g1_i1 Q8IZJ3 CPMD8_HUMAN 2.00E-10 GO:0005615; GO:0010951; GO:0005886; GO:0004867 extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR002350; IPR001599; IPR019742; IPR019565; IPR022041; IPR008930; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 CPAMD8 KIAA1283 Homo sapiens (Human) TR12371_c2_g1_i1 Q2T9X8 SPICE_BOVIN 8.00E-26 GO:0051301; GO:0005814; GO:0046599; GO:0005819; GO:0090307 cell division; centriole; regulation of centriole replication; spindle; spindle assembly involved in mitosis Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) SPICE1 CCDC52 Bos taurus (Bovine) TR12379_c0_g1_i1 A2AR95 LRAD3_MOUSE 8.00E-14 GO:0001540; GO:0016021; GO:0005886; GO:0006898; GO:0070613 beta-amyloid binding; integral to membrane; plasma membrane; receptor-mediated endocytosis; regulation of protein processing IPR023415; IPR002172; Low-density lipoprotein receptor class A domain-containing protein 3 Ldlrad3 Mus musculus (Mouse) TR12382_c1_g1_i1 P23685 NAC1_CANFA 2.00E-24 GO:0030315; GO:0016323; GO:1901660; GO:0070509; GO:0005432; GO:0055013; GO:0060048; GO:0007154; GO:0034614; GO:0035050; GO:0001892; GO:0003007; GO:0005887; GO:0046872; GO:0048747; GO:0009791; GO:0002026; GO:0071436; GO:0097369 T-tubule; basolateral plasma membrane; calcium ion export; calcium ion import; calcium:sodium antiporter activity; cardiac muscle cell development; cardiac muscle contraction; cell communication; cellular response to reactive oxygen species; embryonic heart tube development; embryonic placenta development; heart morphogenesis; integral to plasma membrane; metal ion binding; muscle fiber development; post-embryonic development; regulation of the force of heart contraction; sodium ion export; sodium ion import IPR003644; IPR001623; IPR004836; IPR002987; IPR004837; Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1) SLC8A1 Canis familiaris (Dog) (Canis lupus familiaris) TR12382_c1_g2_i1 Q6H641 MHX2_ORYSJ 2.00E-13 GO:0016021; GO:0006811; GO:0055085; GO:0005774 integral to membrane; ion transport; transmembrane transport; vacuolar membrane IPR004837; Magnesium/proton exchanger 2 (Mg(2+)/H(+) exchanger 2) (Zinc/proton exchanger 2) (Zn(2+)/H(+) exchanger 2) MHX2 Os02g0644900 LOC_Os02g43110 OJ1282_H11.33 P0030D07.11 Oryza sativa subsp. japonica (Rice) TR12386_c0_g2_i1 Q1L8Y6 BBIP1_DANRE 8.00E-22 GO:0034464; GO:0070121; GO:0005929; GO:0042384; GO:0005737; GO:0032402 BBSome; Kupffer's vesicle development; cilium; cilium assembly; cytoplasm; melanosome transport IPR028233; BBSome-interacting protein 1 (BBSome-interacting protein of 10 kDa) bbip1 bbip10 si:ch211-159c12.2 si:ch211-197i12.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR12389_c0_g1_i1 P08548 LIN1_NYCCO 3.00E-12 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR12389_c0_g1_i2 P11369 POL2_MOUSE 5.00E-10 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR013544; IPR005135; IPR000477; Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element-1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] Pol Gm17492 Mus musculus (Mouse) TR1239_c0_g1_i1 Q800K6 TOB1A_XENLA 2.00E-16 GO:0003677; GO:0006281; GO:0000076; GO:0006270; GO:0071165; GO:0000785; GO:0003682; GO:0005737; GO:0005815; GO:0005634; GO:0035563; GO:0033138; GO:0045860; GO:0071168; GO:0030174; GO:0006974; GO:0000922 D3IUT5 DNA binding; DNA repair; DNA replication checkpoint; DNA replication initiation; GINS complex assembly; chromatin; chromatin binding; cytoplasm; microtubule organizing center; nucleus; positive regulation of chromatin binding; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase activity; protein localization to chromatin; regulation of DNA-dependent DNA replication initiation; response to DNA damage stimulus; spindle pole IPR001357; IPR016126; IPR026993; DNA topoisomerase 2-binding protein 1-A (Cut5 protein) (DNA topoisomerase II-binding protein 1-A) (TopBP1-A) (XtopBP) topbp1-A cut5 Xenopus laevis (African clawed frog) TR12390_c1_g1_i1 O88202 LPP60_RAT 1.00E-13 GO:0003847; GO:0004067; GO:0006528; GO:0016042; GO:0004622; GO:0006644 1-alkyl-2-acetylglycerophosphocholine esterase activity; asparaginase activity; asparagine metabolic process; lipid catabolic process; lysophospholipase activity; phospholipid metabolic process IPR002110; IPR020683; IPR006033; IPR006034; IPR027475; IPR027473; IPR027474; 60 kDa lysophospholipase (EC 3.1.1.5) [Includes: L-asparaginase (EC 3.5.1.1) (L-asparagine amidohydrolase); Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47)] Aspg Rattus norvegicus (Rat) TR12390_c2_g1_i1 P57044 ILK_CAVPO 3.00E-08 GO:0005524; GO:0005925; GO:0030027; GO:0005886; GO:0030513; GO:0090263; GO:0045669; GO:0042327; GO:0045893; GO:0004674; GO:0030017 "ATP binding; focal adhesion; lamellipodium; plasma membrane; positive regulation of BMP signaling pathway; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of osteoblast differentiation; positive regulation of phosphorylation; positive regulation of transcription, DNA-dependent; protein serine/threonine kinase activity; sarcomere" IPR002110; IPR020683; IPR016253; IPR011009; IPR000719; IPR001245; Integrin-linked protein kinase (EC 2.7.11.1) (Beta-integrin-linked kinase) ILK Cavia porcellus (Guinea pig) TR12395_c0_g1_i1 Q15751 HERC1_HUMAN 9.00E-29 GO:0005086; GO:0005794; GO:0021702; GO:0005829; GO:0016020; GO:0010507; GO:0050885; GO:0031175; GO:0006810; GO:0004842 ARF guanyl-nucleotide exchange factor activity; Golgi apparatus; cerebellar Purkinje cell differentiation; cytosol; membrane; negative regulation of autophagy; neuromuscular process controlling balance; neuron projection development; transport; ubiquitin-protein ligase activity IPR001870; IPR008985; IPR000569; IPR009091; IPR000408; IPR018355; IPR003877; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HERC1 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 1) (p532) (p619) HERC1 Homo sapiens (Human) TR12400_c0_g1_i1 P35953 VLDLR_RABIT 9.00E-30 GO:0005509; GO:0008203; GO:0005905; GO:0034436; GO:0034437; GO:0016021; GO:0006869; GO:0000122; GO:1900006; GO:0038025; GO:0021517; GO:0034361; GO:0034189; GO:0034447; GO:0030229 calcium ion binding; cholesterol metabolic process; coated pit; glycoprotein transport; glycoprotein transporter activity; integral to membrane; lipid transport; negative regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite development; reelin receptor activity; ventral spinal cord development; very-low-density lipoprotein particle; very-low-density lipoprotein particle binding; very-low-density lipoprotein particle clearance; very-low-density lipoprotein particle receptor activity IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) VLDLR Oryctolagus cuniculus (Rabbit) TR12405_c0_g1_i1 P08361 POL_MLVCB 2.00E-12 GO:0015074; GO:0075713; GO:0046872; GO:0003676; GO:0046718 DNA integration; establishment of integrated proviral latency; metal ion binding; nucleic acid binding; viral entry into host cell IPR001584; IPR012337; Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Integrase p46 (IN)] (Fragment) gag-pol Cas-Br-E murine leukemia virus TR12407_c1_g1_i1 Q8TEP8 CE192_HUMAN 4.00E-11 GO:0000086; GO:0005814; GO:0005813; GO:0051298; GO:0005829; GO:0010923; GO:0019902; GO:0051225 P62136 G2/M transition of mitotic cell cycle; centriole; centrosome; centrosome duplication; cytosol; negative regulation of phosphatase activity; phosphatase binding; spindle assembly Centrosomal protein of 192 kDa (Cep192) CEP192 KIAA1569 PP8407 Homo sapiens (Human) TR12415_c1_g1_i1 Q9Y4F3 MARF1_HUMAN 5.00E-45 GO:0003723; GO:0030154; GO:0007143; GO:0010923; GO:0000166; GO:0048477; GO:0005777; GO:0010468 RNA binding; cell differentiation; female meiosis; negative regulation of phosphatase activity; nucleotide binding; oogenesis; peroxisome; regulation of gene expression IPR024582; IPR024768; IPR012677; IPR021139; IPR025605; IPR000504; Meiosis arrest female protein 1 (Limkain-b1) KIAA0430 LKAP MARF1 Homo sapiens (Human) TR12421_c2_g1_i1 Q17770 PDI2_CAEEL 4.00E-91 GO:0045454; GO:0005783; GO:0005788; GO:0006662; GO:0055114; GO:0018401; GO:0080058; GO:0003756; GO:0015035; GO:0003810 cell redox homeostasis; endoplasmic reticulum; endoplasmic reticulum lumen; glycerol ether metabolic process; oxidation-reduction process; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; protein deglutathionylation; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; protein-glutamine gamma-glutamyltransferase activity IPR005788; IPR005792; IPR005746; IPR012336; IPR017937; IPR013766; Protein disulfide-isomerase 2 (EC 5.3.4.1) (PDI 1) (Prolyl 4-hydroxylase subunit beta-2) pdi-2 C07A12.4 Caenorhabditis elegans TR12423_c1_g1_i1 Q9V535 RBM8A_DROME 3.00E-36 GO:0071013; GO:0005737; GO:0007173; GO:0046595; GO:0035145; GO:0007294; GO:0003729; GO:0006406; GO:0000398; GO:0000226; GO:0000166; GO:0007312; GO:0045451; GO:0007317 P49028 "catalytic step 2 spliceosome; cytoplasm; epidermal growth factor receptor signaling pathway; establishment of pole plasm mRNA localization; exon-exon junction complex; germarium-derived oocyte fate determination; mRNA binding; mRNA export from nucleus; mRNA splicing, via spliceosome; microtubule cytoskeleton organization; nucleotide binding; oocyte nucleus migration involved in oocyte dorsal/ventral axis specification; pole plasm oskar mRNA localization; regulation of pole plasm oskar mRNA localization" IPR012677; IPR008111; IPR000504; RNA-binding protein 8A (Protein tsunagi) tsu Y14 CG8781 Drosophila melanogaster (Fruit fly) TR12425_c1_g1_i1 O46644 CELA1_MACFA 2.00E-08 GO:0005576; GO:0046872; GO:0006508; GO:0004252 extracellular region; metal ion binding; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Chymotrypsin-like elastase family member 1 (EC 3.4.21.36) (Elastase-1) CELA1 ELA1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR12427_c0_g1_i1 Q5THJ4 VP13D_HUMAN 1.00E-12 IPR009060; IPR015940; IPR000449; IPR026847; IPR026854; IPR009543; Vacuolar protein sorting-associated protein 13D VPS13D KIAA0453 Homo sapiens (Human) TR12432_c0_g2_i1 Q8SSK6 ALDR_ENCCU 6.00E-27 GO:0004032; GO:0005737 alditol:NADP+ 1-oxidoreductase activity; cytoplasm IPR001395; IPR018170; IPR020471; IPR023210; Aldose reductase (AR) (EC 1.1.1.21) (Aldehyde reductase) ECU01_0970 Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) TR1244_c0_g1_i1 O75095 MEGF6_HUMAN 4.00E-17 GO:0005509; GO:0005576 O15265; O00555 calcium ion binding; extracellular region IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR002049; IPR011489; IPR009030; Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) TR12441_c0_g1_i1 P48067 SC6A9_HUMAN 1.00E-33 GO:0015375; GO:0005887; GO:0005328 glycine:sodium symporter activity; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) SLC6A9 Homo sapiens (Human) TR12442_c0_g1_i1 O75445 USH2A_HUMAN 3.00E-06 GO:0016324; GO:0005604; GO:0005518; GO:0005737; GO:0035315; GO:0060113; GO:0016021; GO:0048496; GO:0017022; GO:0045494; GO:0050896; GO:0050953; GO:0007605; GO:0002142; GO:0060171; GO:0007601 apical plasma membrane; basement membrane; collagen binding; cytoplasm; hair cell differentiation; inner ear receptor cell differentiation; integral to membrane; maintenance of organ identity; myosin binding; photoreceptor cell maintenance; response to stimulus; sensory perception of light stimulus; sensory perception of sound; stereocilia ankle link complex; stereocilium membrane; visual perception IPR008985; IPR013320; IPR002049; IPR003961; IPR013783; IPR006558; IPR001791; IPR008211; IPR026915; Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein) USH2A Homo sapiens (Human) TR12449_c0_g1_i1 A7E2V4 K0913_HUMAN 5.00E-13 GO:0008270 zinc ion binding IPR007527; Zinc finger SWIM domain-containing protein 8 ZSWIM8 KIAA0913 Homo sapiens (Human) TR1245_c0_g1_i1 Q9BXS5 AP1M1_HUMAN 3.00E-40 GO:0000139; GO:0019886; GO:0030131; GO:0030665; GO:0030659; GO:0005829; GO:0035646; GO:0006886; GO:0005765; GO:0032438; GO:0019048; GO:0006892; GO:0050690; GO:0032588; GO:0016032 O95751; Q14872 Golgi membrane; antigen processing and presentation of exogenous peptide antigen via MHC class II; clathrin adaptor complex; clathrin-coated vesicle membrane; cytoplasmic vesicle membrane; cytosol; endosome to melanosome transport; intracellular protein transport; lysosomal membrane; melanosome organization; modulation by virus of host morphology or physiology; post-Golgi vesicle-mediated transport; regulation of defense response to virus by virus; trans-Golgi network membrane; viral process IPR022775; IPR001392; IPR008968; IPR018240; IPR011012; AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adapter-related protein complex 1 subunit mu-1) (Adaptor protein complex AP-1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin) AP1M1 CLTNM Homo sapiens (Human) TR12451_c0_g1_i2 O97508 THIO_HORSE 2.00E-25 GO:0045454; GO:0005829; GO:0005576; GO:0006662; GO:0005739; GO:0046826; GO:0000122; GO:0005634; GO:0055114; GO:0015037; GO:0043388; GO:0015035; GO:0033158; GO:0009314; GO:0006351 "cell redox homeostasis; cytosol; extracellular region; glycerol ether metabolic process; mitochondrion; negative regulation of protein export from nucleus; negative regulation of transcription from RNA polymerase II promoter; nucleus; oxidation-reduction process; peptide disulfide oxidoreductase activity; positive regulation of DNA binding; protein disulfide oxidoreductase activity; regulation of protein import into nucleus, translocation; response to radiation; transcription, DNA-dependent" IPR005746; IPR012336; IPR017937; IPR013766; Thioredoxin (Trx) TXN Equus caballus (Horse) TR12453_c0_g1_i1 A6QLU6 GP133_BOVIN 5.00E-15 GO:0004930; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR008985; IPR013320; IPR017981; IPR000832; IPR017983; IPR000203; Probable G-protein coupled receptor 133 GPR133 Bos taurus (Bovine) TR12473_c0_g1_i1 Q8NBN7 RDH13_HUMAN 8.00E-49 GO:0005739; GO:0016491 mitochondrion; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Retinol dehydrogenase 13 (EC 1.1.1.-) RDH13 PSEC0082 UNQ736/PRO1430 Homo sapiens (Human) TR12482_c1_g1_i1 P55273 CDN2D_HUMAN 3.00E-10 GO:0000731; GO:0000082; GO:0048102; GO:0007050; GO:0004861; GO:0005829; GO:0030308; GO:0008285; GO:0043154; GO:1902230; GO:0005634; GO:0000079; GO:0009411; GO:0032526; GO:0033280; GO:0007605 Q00534 DNA synthesis involved in DNA repair; G1/S transition of mitotic cell cycle; autophagic cell death; cell cycle arrest; cyclin-dependent protein serine/threonine kinase inhibitor activity; cytosol; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; nucleus; regulation of cyclin-dependent protein serine/threonine kinase activity; response to UV; response to retinoic acid; response to vitamin D; sensory perception of sound IPR002110; IPR020683; Cyclin-dependent kinase 4 inhibitor D (p19-INK4d) CDKN2D Homo sapiens (Human) TR12485_c0_g1_i1 Q9C0G6 DYH6_HUMAN 5.00E-65 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 6, axonemal (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6)" DNAH6 DNAHC6 DNHL1 HL2 KIAA1697 Homo sapiens (Human) TR12485_c2_g1_i1 Q0VDD8 DYH14_HUMAN 1.00E-24 GO:0005524; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR026983; IPR024743; IPR024317; IPR004273; IPR027417; "Dynein heavy chain 14, axonemal (Axonemal beta dynein heavy chain 14) (Ciliary dynein heavy chain 14)" DNAH14 C1orf67 Homo sapiens (Human) TR12485_c4_g1_i1 Q8VHE6 DYH5_MOUSE 5.00E-22 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 5, axonemal (Axonemal beta dynein heavy chain 5) (mDNAH5) (Ciliary dynein heavy chain 5)" Dnah5 Dnahc5 Mus musculus (Mouse) TR12487_c0_g1_i1 Q60HC5 DHC24_MACFA 5.00E-34 GO:0000139; GO:0008762; GO:0006695; GO:0050614; GO:0005783; GO:0005789; GO:0019899; GO:0050660; GO:0016021; GO:0043066; GO:0043154; GO:0005634; GO:0042605; GO:0006979; GO:0043588; GO:0009888 Golgi membrane; UDP-N-acetylmuramate dehydrogenase activity; cholesterol biosynthetic process; delta24-sterol reductase activity; endoplasmic reticulum; endoplasmic reticulum membrane; enzyme binding; flavin adenine dinucleotide binding; integral to membrane; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; nucleus; peptide antigen binding; response to oxidative stress; skin development; tissue development IPR016169; IPR016166; IPR006094; Steroid biosynthesis; cholesterol biosynthesis. Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol delta-24-reductase) DHCR24 QmoA-12363 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR12491_c1_g1_i1 Q5R439 VIGLN_PONAB 1.00E-31 GO:0003723; GO:0008203; GO:0005737; GO:0034364; GO:0006869; GO:0005634 RNA binding; cholesterol metabolic process; cytoplasm; high-density lipoprotein particle; lipid transport; nucleus IPR004087; IPR004088; Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) HDLBP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR12497_c0_g1_i1 Q6NY15 TSG10_MOUSE 5.00E-29 GO:0030031; GO:0005737; GO:0031514; GO:0043005; GO:0031965; GO:0005198 Q61221-1 cell projection assembly; cytoplasm; motile cilium; neuron projection; nuclear membrane; structural molecule activity Testis-specific gene 10 protein Tsga10 Mus musculus (Mouse) TR12499_c0_g2_i1 Q8K368 FANCI_MOUSE 2.00E-17 GO:0006281; GO:0007049; GO:0005634; GO:0005886; GO:0031398 DNA repair; cell cycle; nucleus; plasma membrane; positive regulation of protein ubiquitination IPR026171; Fanconi anemia group I protein homolog (Protein FACI) Fanci Mus musculus (Mouse) TR12499_c1_g1_i1 Q9NVI1 FANCI_HUMAN 1.00E-20 GO:0003677; GO:0006281; GO:0007049; GO:0005654; GO:0005886; GO:0031398 Q9BXW9 DNA binding; DNA repair; cell cycle; nucleoplasm; plasma membrane; positive regulation of protein ubiquitination IPR026171; Fanconi anemia group I protein (Protein FACI) FANCI KIAA1794 Homo sapiens (Human) TR12500_c0_g1_i1 Q6EGI0 COX1_PAPBU 5.00E-72 GO:0009060; GO:0004129; GO:0009055; GO:0020037; GO:0016021; GO:0005506; GO:0005743; GO:0006119; GO:0045277 aerobic respiration; cytochrome-c oxidase activity; electron carrier activity; heme binding; integral to membrane; iron ion binding; mitochondrial inner membrane; oxidative phosphorylation; respiratory chain complex IV IPR000883; IPR023615; IPR023616; Energy metabolism; oxidative phosphorylation. Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide I) MT-CO1 COI COXI MTCO1 Pappogeomys bulleri (Buller's pocket gopher) TR12500_c0_g2_i1 Q0H8X8 AI2_USTMA 2.00E-10 GO:0003677; GO:0009060; GO:0004129; GO:0009055; GO:0004519; GO:0020037; GO:0016021; GO:0006314; GO:0005506; GO:0005739; GO:0090305 DNA binding; aerobic respiration; cytochrome-c oxidase activity; electron carrier activity; endonuclease activity; heme binding; integral to membrane; intron homing; iron ion binding; mitochondrion; nucleic acid phosphodiester bond hydrolysis IPR000883; IPR023616; IPR001982; IPR027434; Probable intron-encoded endonuclease aI2 [Cleaved into: Truncated non-functional cytochrome oxidase 1; Intron-encoded endonuclease aI2 (EC 3.1.-.-)] aI2 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR12500_c1_g1_i1 O21079 COX1_MYXGL 5.00E-62 GO:0009060; GO:0004129; GO:0009055; GO:0020037; GO:0016021; GO:0005506; GO:0005743; GO:0006119; GO:0045277 aerobic respiration; cytochrome-c oxidase activity; electron carrier activity; heme binding; integral to membrane; iron ion binding; mitochondrial inner membrane; oxidative phosphorylation; respiratory chain complex IV IPR000883; IPR023615; IPR023616; Energy metabolism; oxidative phosphorylation. Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide I) MT-CO1 COI COXI MTCO1 Myxine glutinosa (Atlantic hagfish) TR12513_c1_g1_i1 B4LPX5 TRET1_DROVI 9.00E-18 GO:0016021; GO:0005886; GO:0015574 integral to membrane; plasma membrane; trehalose transmembrane transporter activity IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; Facilitated trehalose transporter Tret1 Tret1 GJ20366 Drosophila virilis (Fruit fly) TR12513_c1_g2_i1 B4LPX5 TRET1_DROVI 9.00E-18 GO:0016021; GO:0005886; GO:0015574 integral to membrane; plasma membrane; trehalose transmembrane transporter activity IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; Facilitated trehalose transporter Tret1 Tret1 GJ20366 Drosophila virilis (Fruit fly) TR12515_c2_g1_i1 P84104 SRSF3_MOUSE 1.00E-24 GO:0003723; GO:0008380; GO:0008286; GO:0006397; GO:0016607; GO:0000166 RNA binding; RNA splicing; insulin receptor signaling pathway; mRNA processing; nuclear speck; nucleotide binding IPR012677; IPR000504; "Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Protein X16) (Splicing factor, arginine/serine-rich 3)" Srsf3 Sfrs3 Srp20 X16 Mus musculus (Mouse) TR12520_c1_g1_i1 Q8NAP3 ZBT38_HUMAN 1.00E-08 GO:0003677; GO:0046872; GO:0005634; GO:0045944; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 38 ZBTB38 Homo sapiens (Human) TR12534_c0_g1_i1 P18142 D2_DICDI 3.00E-21 GO:0004091; GO:0033118 carboxylesterase activity; esterosome membrane IPR002018; IPR019826; IPR019819; cAMP-regulated D2 protein D2 DDB_G0283085 Dictyostelium discoideum (Slime mold) TR12556_c0_g1_i1 Q8BH16 FBXL2_MOUSE 6.00E-07 GO:0016020; GO:0006513; GO:0006511; GO:0004842 membrane; protein monoubiquitination; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR001810; IPR006553; F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) Fbxl2 Fbl2 Mus musculus (Mouse) TR12560_c0_g1_i1 P08548 LIN1_NYCCO 5.00E-06 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR12563_c1_g1_i1 P42674 BP10_PARLI 3.00E-12 GO:0005938; GO:0005615; GO:0004222; GO:0048471; GO:0006508; GO:0008270 cell cortex; extracellular space; metalloendopeptidase activity; perinuclear region of cytoplasm; proteolysis; zinc ion binding IPR000859; IPR000742; IPR013032; IPR024079; IPR001506; IPR006026; IPR017369; Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) TR12571_c0_g1_i1 Q9UFB7 ZBT47_HUMAN 2.00E-11 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 47 (Zinc finger protein 651) ZBTB47 KIAA1190 ZNF651 Homo sapiens (Human) TR12571_c2_g1_i1 Q6ZSB9 ZBT49_HUMAN 3.00E-10 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR020542; IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) ZBTB49 ZNF509 Homo sapiens (Human) TR12574_c0_g2_i1 Q66J90 SET1B_XENLA 8.00E-12 GO:0003723; GO:0005694; GO:0034968; GO:0018024; GO:0016607; GO:0000166; GO:0006355; GO:0006351 "RNA binding; chromosome; histone lysine methylation; histone-lysine N-methyltransferase activity; nuclear speck; nucleotide binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR024657; IPR015722; IPR012677; IPR003616; IPR000504; IPR001214; Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.43) (SET domain-containing protein 1B) setd1b Xenopus laevis (African clawed frog) TR12580_c1_g1_i1 Q6ZWH5 NEK10_HUMAN 2.00E-23 GO:0005524; GO:0046872; GO:0018108; GO:0004674; GO:0004713 ATP binding; metal ion binding; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity IPR011989; IPR016024; IPR011009; IPR000719; IPR017441; IPR002290; IPR008266; Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (Never in mitosis A-related kinase 10) (NimA-related protein kinase 10) NEK10 Homo sapiens (Human) TR12581_c0_g1_i1 O81884 GALDH_ARATH 7.00E-51 GO:0019853; GO:0010349; GO:0005829; GO:0006012 L-ascorbic acid biosynthetic process; L-galactose dehydrogenase activity; cytosol; galactose metabolic process IPR001395; IPR023210; L-galactose dehydrogenase (At-GalDH) (L-GalDH) (EC 1.1.1.316) LGALDH At4g33670 T16L1.160 Arabidopsis thaliana (Mouse-ear cress) TR12584_c1_g1_i1 P82987 ATL3_HUMAN 4.00E-06 GO:0008237; GO:0005578; GO:0008270 metallopeptidase activity; proteinaceous extracellular matrix; zinc ion binding IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013273; IPR010909; IPR000884; ADAMTS-like protein 3 (ADAMTSL-3) (Punctin-2) ADAMTSL3 KIAA1233 Homo sapiens (Human) TR12586_c0_g2_i1 O88279 SLIT1_RAT 3.00E-15 GO:0048846; GO:0007420; GO:0005509; GO:0005737; GO:0033563; GO:0040023; GO:0005615; GO:0043395; GO:0008045; GO:0050919; GO:0048843; GO:0051964; GO:0031290; GO:0021510; GO:0022028 axon extension involved in axon guidance; brain development; calcium ion binding; cytoplasm; dorsal/ventral axon guidance; establishment of nucleus localization; extracellular space; heparan sulfate proteoglycan binding; motor neuron axon guidance; negative chemotaxis; negative regulation of axon extension involved in axon guidance; negative regulation of synapse assembly; retinal ganglion cell axon guidance; spinal cord development; tangential migration from the subventricular zone to the olfactory bulb IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4) Slit1 Megf4 Rattus norvegicus (Rat) TR12588_c0_g1_i1 Q29450 ADCY7_BOVIN 3.00E-16 GO:0005524; GO:0004016; GO:0071361; GO:0016021; GO:0035556; GO:0046872; GO:0005886; GO:0030819 ATP binding; adenylate cyclase activity; cellular response to ethanol; integral to membrane; intracellular signal transduction; metal ion binding; plasma membrane; positive regulation of cAMP biosynthetic process IPR001054; IPR018297; IPR009398; Adenylate cyclase type 7 (EC 4.6.1.1) (ATP pyrophosphate-lyase 7) (Adenylate cyclase type VII) (Adenylyl cyclase 7) ADCY7 Bos taurus (Bovine) TR12588_c0_g2_i1 Q07553 GCY3E_DROME 2.00E-31 GO:0005524; GO:0005525; GO:0004383; GO:0005887; GO:0035556; GO:0004872; GO:0016772 "ATP binding; GTP binding; guanylate cyclase activity; integral to plasma membrane; intracellular signal transduction; receptor activity; transferase activity, transferring phosphorus-containing groups" IPR001054; IPR018297; IPR001828; IPR011009; IPR028082; IPR000719; IPR001245; Guanylate cyclase 32E (EC 4.6.1.2) Gyc32E GC CG33114 Drosophila melanogaster (Fruit fly) TR12592_c0_g1_i1 Q96CN5 LRC45_HUMAN 1.00E-11 GO:0005813 centrosome Leucine-rich repeat-containing protein 45 LRRC45 Homo sapiens (Human) TR12601_c0_g1_i1 P50580 PA2G4_MOUSE 8.00E-18 GO:0003677; GO:0003723; GO:0005737; GO:0045892; GO:0005730; GO:0005634; GO:0006364; GO:0006417; GO:0030529; GO:0003700; GO:0006351 "DNA binding; RNA binding; cytoplasm; negative regulation of transcription, DNA-dependent; nucleolus; nucleus; rRNA processing; regulation of translation; ribonucleoprotein complex; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004545; IPR000994; IPR018349; IPR011991; Proliferation-associated protein 2G4 (IRES-specific cellular trans-acting factor 45 kDa) (ITAF45) (Mpp1) (Proliferation-associated protein 1) (Protein p38-2G4) Pa2g4 Ebp1 Plfap Mus musculus (Mouse) TR12612_c0_g2_i1 P51689 ARSD_HUMAN 5.00E-07 GO:0004065; GO:0005788; GO:0006687; GO:0005764; GO:0046872; GO:0043687; GO:0044281 arylsulfatase activity; endoplasmic reticulum lumen; glycosphingolipid metabolic process; lysosome; metal ion binding; post-translational protein modification; small molecule metabolic process IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase D (ASD) (EC 3.1.6.-) ARSD Homo sapiens (Human) TR1262_c0_g1_i1 Q9UPU7 TBD2B_HUMAN 8.00E-10 GO:0005097; GO:0005543; GO:0032851 O95166; Q9H0R8; P60520; Q9GZQ8; Q9BXW4 Rab GTPase activator activity; phospholipid binding; positive regulation of Rab GTPase activity IPR011993; IPR001849; IPR000195; TBC1 domain family member 2B TBC1D2B KIAA1055 Homo sapiens (Human) TR12624_c0_g1_i1 Q6DFF7 ENC2_XENLA 1.00E-11 GO:0031463; GO:0042787; GO:0006446 Cul3-RING ubiquitin ligase complex; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of translational initiation IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 25 (Ectoderm-neural cortex protein 2) (ENC-2) klhl25 enc2 Xenopus laevis (African clawed frog) TR12624_c2_g1_i1 Q6PF15 KLH35_HUMAN 1.00E-06 IPR011705; IPR015916; IPR006652; Kelch-like protein 35 KLHL35 Homo sapiens (Human) TR12632_c0_g1_i1 P27708 PYR1_HUMAN 1.00E-39 GO:0044205; GO:0006207; GO:0005524; GO:0006228; GO:0070335; GO:0004070; GO:0070409; GO:0004088; GO:0035690; GO:0071364; GO:0005829; GO:0004151; GO:0017144; GO:0009790; GO:0007565; GO:0006543; GO:0006541; GO:0042802; GO:0007595; GO:0046872; GO:0043025; GO:0016363; GO:0031100; GO:0018107; GO:0046777; GO:0043234; GO:0004672; GO:0046134; GO:0014075; GO:0031000; GO:0051414; GO:0033574; GO:0043195 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; ATP binding; UTP biosynthetic process; aspartate binding; aspartate carbamoyltransferase activity; carbamoyl phosphate biosynthetic process; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; cellular response to drug; cellular response to epidermal growth factor stimulus; cytosol; dihydroorotase activity; drug metabolic process; embryo development; female pregnancy; glutamine catabolic process; glutamine metabolic process; identical protein binding; lactation; metal ion binding; neuronal cell body; nuclear matrix; organ regeneration; peptidyl-threonine phosphorylation; protein autophosphorylation; protein complex; protein kinase activity; pyrimidine nucleoside biosynthetic process; response to amine stimulus; response to caffeine; response to cortisol stimulus; response to testosterone stimulus; terminal bouton IPR006132; IPR006130; IPR002082; IPR006131; IPR011761; IPR013815; IPR013816; IPR006275; IPR005481; IPR005480; IPR006274; IPR002474; IPR005479; IPR005483; IPR002195; IPR017926; IPR011059; IPR011607; IPR016185; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] CAD Homo sapiens (Human) TR12632_c0_g2_i1 P27708 PYR1_HUMAN 1.00E-39 GO:0044205; GO:0006207; GO:0005524; GO:0006228; GO:0070335; GO:0004070; GO:0070409; GO:0004088; GO:0035690; GO:0071364; GO:0005829; GO:0004151; GO:0017144; GO:0009790; GO:0007565; GO:0006543; GO:0006541; GO:0042802; GO:0007595; GO:0046872; GO:0043025; GO:0016363; GO:0031100; GO:0018107; GO:0046777; GO:0043234; GO:0004672; GO:0046134; GO:0014075; GO:0031000; GO:0051414; GO:0033574; GO:0043195 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; ATP binding; UTP biosynthetic process; aspartate binding; aspartate carbamoyltransferase activity; carbamoyl phosphate biosynthetic process; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; cellular response to drug; cellular response to epidermal growth factor stimulus; cytosol; dihydroorotase activity; drug metabolic process; embryo development; female pregnancy; glutamine catabolic process; glutamine metabolic process; identical protein binding; lactation; metal ion binding; neuronal cell body; nuclear matrix; organ regeneration; peptidyl-threonine phosphorylation; protein autophosphorylation; protein complex; protein kinase activity; pyrimidine nucleoside biosynthetic process; response to amine stimulus; response to caffeine; response to cortisol stimulus; response to testosterone stimulus; terminal bouton IPR006132; IPR006130; IPR002082; IPR006131; IPR011761; IPR013815; IPR013816; IPR006275; IPR005481; IPR005480; IPR006274; IPR002474; IPR005479; IPR005483; IPR002195; IPR017926; IPR011059; IPR011607; IPR016185; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] CAD Homo sapiens (Human) TR12633_c1_g1_i1 O15973 OPSD1_MIZYE 4.00E-34 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR000856; IPR027430; "Rhodopsin, GQ-coupled (GQ-rhodopsin)" SCOP1 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) TR12643_c0_g1_i1 P56395 CYB5_MOUSE 7.00E-22 GO:0005789; GO:0006631; GO:0020037; GO:0016021; GO:0016020; GO:0046872; GO:0005739; GO:0004768 endoplasmic reticulum membrane; fatty acid metabolic process; heme binding; integral to membrane; membrane; metal ion binding; mitochondrion; stearoyl-CoA 9-desaturase activity IPR001199; IPR018506; Cytochrome b5 Cyb5a Cyb5 Mus musculus (Mouse) TR12651_c0_g1_i1 Q9XZP2 CALM2_BRAFL 6.00E-22 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-2 (CaM 2) CAM2 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR12659_c1_g1_i1 Q9WVM6 TLL2_MOUSE 2.00E-38 GO:0005509; GO:0030154; GO:0005576; GO:0004222; GO:0007275; GO:0006508; GO:0008270 calcium ion binding; cell differentiation; extracellular region; metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Tolloid-like protein 2 (EC 3.4.24.-) Tll2 Mus musculus (Mouse) TR12659_c3_g1_i1 O70244 CUBN_RAT 2.00E-27 GO:0031526; GO:0005509; GO:0008203; GO:0031419; GO:0030666; GO:0010008; GO:0030492; GO:0020028; GO:0042802; GO:0001701; GO:0043202; GO:0005765; GO:0043234; GO:0070207; GO:0004872; GO:0006898; GO:0007584; GO:0006766 Itself brush border membrane; calcium ion binding; cholesterol metabolic process; cobalamin binding; endocytic vesicle membrane; endosome membrane; hemoglobin binding; hemoglobin import; identical protein binding; in utero embryonic development; lysosomal lumen; lysosomal membrane; protein complex; protein homotrimerization; receptor activity; receptor-mediated endocytosis; response to nutrient; vitamin metabolic process IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; Cubilin (460 kDa receptor) (Glycoprotein 280) (gp280) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) Cubn Ifcr Rattus norvegicus (Rat) TR12659_c4_g1_i1 Q4A3R3 DMBT1_PIG 5.00E-11 GO:0030154; GO:0005576; GO:0019898; GO:0016021; GO:0007275; GO:0015031; GO:0005044; GO:0030658; GO:0035375; GO:0042589 cell differentiation; extracellular region; extrinsic to membrane; integral to membrane; multicellular organismal development; protein transport; scavenger receptor activity; transport vesicle membrane; zymogen binding; zymogen granule membrane IPR000859; IPR001190; IPR017448; IPR001507; IPR017977; Deleted in malignant brain tumors 1 protein (Hensin) DMBT1 Sus scrofa (Pig) TR12659_c6_g1_i1 Q96PD2 DCBD2_HUMAN 4.00E-11 GO:0007155; GO:0009986; GO:0005887; GO:0030522; GO:0030308; GO:0042060 P46109 cell adhesion; cell surface; integral to plasma membrane; intracellular receptor signaling pathway; negative regulation of cell growth; wound healing IPR000421; IPR000859; IPR008979; IPR004043; "Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein)" DCBLD2 CLCP1 ESDN Homo sapiens (Human) TR12670_c2_g1_i1 Q5T2S8 ARMC4_HUMAN 4.00E-114 IPR011989; IPR016024; IPR000225; IPR026959; IPR023231; Armadillo repeat-containing protein 4 ARMC4 Homo sapiens (Human) TR12679_c1_g1_i1 O95393 BMP10_HUMAN 2.00E-07 GO:0030509; GO:0030018; GO:0032924; GO:0007512; GO:0055009; GO:0060038; GO:0014898; GO:0007155; GO:0009986; GO:0030198; GO:0005615; GO:0060347; GO:0005179; GO:0010614; GO:0030308; GO:0010596; GO:0060389; GO:0060045; GO:0010613; GO:2000138; GO:0010862; GO:0060298; GO:0045893; GO:0033612; GO:0055117; GO:0045214; GO:0055015; GO:0055010 "BMP signaling pathway; Z disc; activin receptor signaling pathway; adult heart development; atrial cardiac muscle tissue morphogenesis; cardiac muscle cell proliferation; cardiac muscle hypertrophy in response to stress; cell adhesion; cell surface; extracellular matrix organization; extracellular space; heart trabecula formation; hormone activity; negative regulation of cardiac muscle hypertrophy; negative regulation of cell growth; negative regulation of endothelial cell migration; pathway-restricted SMAD protein phosphorylation; positive regulation of cardiac muscle cell proliferation; positive regulation of cardiac muscle hypertrophy; positive regulation of cell proliferation involved in heart morphogenesis; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of sarcomere organization; positive regulation of transcription, DNA-dependent; receptor serine/threonine kinase binding; regulation of cardiac muscle contraction; sarcomere organization; ventricular cardiac muscle cell development; ventricular cardiac muscle tissue morphogenesis" IPR002405; IPR001839; IPR001111; IPR015615; IPR017948; Bone morphogenetic protein 10 (BMP-10) BMP10 Homo sapiens (Human) TR1268_c0_g1_i1 Q76LL6 FHOD3_MOUSE 1.00E-28 GO:0030018; GO:0051639; GO:0007015; GO:0005856; GO:0030837; GO:0030017; GO:0045214 Z disc; actin filament network formation; actin filament organization; cytoskeleton; negative regulation of actin filament polymerization; sarcomere; sarcomere organization IPR016024; IPR014767; IPR015425; IPR027651; IPR014768; FH1/FH2 domain-containing protein 3 (Formin homolog overexpressed in spleen 2) (mFHOS2) Fhod3 Fhos2 Kiaa1695 Mus musculus (Mouse) TR12681_c0_g1_i1 Q6PGP7 TTC37_HUMAN 9.00E-23 GO:0055087; GO:0005634; GO:0035327 Q8N7H5 Ski complex; nucleus; transcriptionally active chromatin IPR006597; IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 37 (TPR repeat protein 37) (SKI3 homolog) (Ski3) (Tricho-hepatic-enteric syndrome protein) (Thespin) TTC37 KIAA0372 Homo sapiens (Human) TR12684_c0_g1_i1 P46429 GST2_MANSE 2.00E-23 GO:0004364 glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase 2 (EC 2.5.1.18) (GST class-sigma) GST2 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) TR12686_c0_g1_i1 O35142 COPB2_RAT 5.00E-54 GO:0030663; GO:0000139; GO:0006886; GO:0030117; GO:0005198; GO:0016192 COPI-coated vesicle membrane; Golgi membrane; intracellular protein transport; membrane coat; structural molecule activity; vesicle-mediated transport IPR006692; IPR016453; IPR020472; IPR015943; IPR001680; IPR017986; Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) Copb2 Rattus norvegicus (Rat) TR1269_c0_g1_i1 Q8N2E2 VWDE_HUMAN 2.00E-14 GO:0005576 extracellular region IPR000742; IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) TR12697_c0_g1_i1 P17563 SBP1_MOUSE 5.00E-17 GO:0050873; GO:0005829; GO:0016020; GO:0005634; GO:0015031; GO:0008430 brown fat cell differentiation; cytosol; membrane; nucleus; protein transport; selenium binding IPR008826; IPR015943; Selenium-binding protein 1 (56 kDa selenium-binding protein) (SBP56) (SP56) Selenbp1 Lpsb Mus musculus (Mouse) TR12699_c1_g1_i1 Q7TQE7 K0895_MOUSE 1.00E-35 IPR012548; Uncharacterized protein KIAA0895 Kiaa0895 Mus musculus (Mouse) TR12703_c1_g1_i1 Q99PW8 KIF17_MOUSE 9.00E-52 GO:0005524; GO:0036064; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0007018; GO:0007017; GO:0031503; GO:0015031; GO:0016192 Q9Z0V2 ATP binding; cilium basal body; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement; microtubule-based process; protein complex localization; protein transport; vesicle-mediated transport IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF17 (MmKIF17) Kif17 Mus musculus (Mouse) TR12709_c0_g2_i1 Q56R14 TRI33_XENLA 2.00E-07 GO:0003677; GO:0016874; GO:0005634; GO:0016567; GO:0006355; GO:0006351; GO:0008270 "DNA binding; ligase activity; nucleus; protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 ecto Xenopus laevis (African clawed frog) TR12711_c0_g1_i1 O77487 FUT2_PONPY 9.00E-06 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2)" FUT2 Pongo pygmaeus (Bornean orangutan) TR12728_c0_g1_i1 Q80SU7 GVIN1_MOUSE 5.00E-07 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR027417; Interferon-induced very large GTPase 1 (Very large-inducible GTPase-1) (VLIG-1) Gvin1 Mus musculus (Mouse) TR12734_c0_g2_i1 P86952 TYRO_PINMA 3.00E-12 GO:0005576; GO:0046872; GO:0055114; GO:0016491 extracellular region; metal ion binding; oxidation-reduction process; oxidoreductase activity IPR002227; IPR008922; Tyrosinase-like protein (Tyrosinase-2) Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) TR12737_c0_g1_i1 B2RR83 YTDC2_MOUSE 1.00E-44 GO:0005524; GO:0008026; GO:0003676 ATP binding; ATP-dependent helicase activity; nucleic acid binding IPR002110; IPR020683; IPR011545; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; IPR001374; IPR007275; Probable ATP-dependent RNA helicase YTHDC2 (EC 3.6.4.13) Ythdc2 Mus musculus (Mouse) TR12738_c0_g1_i1 Q9JJZ5 EGFL6_MOUSE 1.00E-07 GO:0005604; GO:0005509; GO:0007155; GO:0030154; GO:0030198; GO:0016020; GO:0007275; GO:0010811 basement membrane; calcium ion binding; cell adhesion; cell differentiation; extracellular matrix organization; membrane; multicellular organismal development; positive regulation of cell-substrate adhesion IPR008985; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR000998; Epidermal growth factor-like protein 6 (EGF-like protein 6) (MAM and EGF domains-containing gene protein) (Protein W80) Egfl6 Maeg Mus musculus (Mouse) TR12738_c0_g2_i1 Q0PMG2 MDGA1_MOUSE 2.00E-25 GO:0046658; GO:0021799; GO:0001764 anchored to plasma membrane; cerebral cortex radially oriented cell migration; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 Mdga1 Mus musculus (Mouse) TR12741_c1_g1_i1 Q9P2N4 ATS9_HUMAN 1.00E-16 GO:0005615; GO:0006516; GO:0004222; GO:0008237; GO:0007275; GO:0045636; GO:0005578; GO:0006508; GO:0008270 extracellular space; glycoprotein catabolic process; metalloendopeptidase activity; metallopeptidase activity; multicellular organismal development; positive regulation of melanocyte differentiation; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR012314; IPR001590; IPR013273; IPR002870; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAM-TS 9) (ADAM-TS9) (ADAMTS-9) (EC 3.4.24.-) ADAMTS9 KIAA1312 Homo sapiens (Human) TR12750_c0_g1_i1 Q9Y2G8 DJC16_HUMAN 2.00E-08 GO:0045454; GO:0016021 cell redox homeostasis; integral to membrane IPR001623; IPR018253; IPR012336; IPR013766; DnaJ homolog subfamily C member 16 DNAJC16 KIAA0962 Homo sapiens (Human) TR12758_c0_g1_i1 O14792 HS3S1_HUMAN 9.00E-16 GO:0005796; GO:0008467; GO:0005975; GO:0006024; GO:0016021; GO:0044281; GO:0008146 Golgi lumen; [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity; carbohydrate metabolic process; glycosaminoglycan biosynthetic process; integral to membrane; small molecule metabolic process; sulfotransferase activity IPR027417; IPR000863; Heparan sulfate glucosamine 3-O-sulfotransferase 1 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1) (3-OST-1) (Heparan sulfate 3-O-sulfotransferase 1) (h3-OST-1) HS3ST1 3OST 3OST1 Homo sapiens (Human) TR12761_c1_g1_i1 Q9H6R0 DHX33_HUMAN 7.00E-19 GO:0005524; GO:0008026; GO:0005730; GO:0005654; GO:0045943; GO:0000182 ATP binding; ATP-dependent helicase activity; nucleolus; nucleoplasm; positive regulation of transcription from RNA polymerase I promoter; rDNA binding IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Putative ATP-dependent RNA helicase DHX33 (EC 3.6.4.13) (DEAH box protein 33) DHX33 DDX33 Homo sapiens (Human) TR12762_c0_g1_i1 Q90WJ8 AJL2_ANGJA 2.00E-08 GO:0030246; GO:0050829; GO:0005576; GO:0043152 carbohydrate binding; defense response to Gram-negative bacterium; extracellular region; induction of bacterial agglutination IPR001304; IPR016186; IPR018378; IPR016187; Lactose-binding lectin l-2 (Ajl-2) l-2 Anguilla japonica (Japanese eel) TR12766_c0_g1_i1 Q9P2N4 ATS9_HUMAN 3.00E-28 GO:0005615; GO:0006516; GO:0004222; GO:0008237; GO:0007275; GO:0045636; GO:0005578; GO:0006508; GO:0008270 extracellular space; glycoprotein catabolic process; metalloendopeptidase activity; metallopeptidase activity; multicellular organismal development; positive regulation of melanocyte differentiation; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR012314; IPR001590; IPR013273; IPR002870; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAM-TS 9) (ADAM-TS9) (ADAMTS-9) (EC 3.4.24.-) ADAMTS9 KIAA1312 Homo sapiens (Human) TR12766_c0_g2_i1 P59510 ATS20_HUMAN 4.00E-33 GO:0030198; GO:0005615; GO:0004222; GO:0043066; GO:0045636; GO:0009967; GO:0005578; GO:0006508; GO:0008270 extracellular matrix organization; extracellular space; metalloendopeptidase activity; negative regulation of apoptotic process; positive regulation of melanocyte differentiation; positive regulation of signal transduction; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR012314; IPR001590; IPR013273; IPR002870; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAM-TS 20) (ADAM-TS20) (ADAMTS-20) (EC 3.4.24.-) ADAMTS20 Homo sapiens (Human) TR12774_c2_g1_i1 Q28C33 TBC30_XENTR 4.00E-52 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; TBC1 domain family member 30 tbc1d30 TEgg107a03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR12777_c0_g1_i1 Q15008 PSMD6_HUMAN 6.00E-31 GO:0016887; GO:0006977; GO:0000082; GO:0031145; GO:0002479; GO:0006915; GO:0005829; GO:0010467; GO:0016071; GO:0043066; GO:0051436; GO:0005654; GO:0051437; GO:0022624; GO:0000209; GO:0006521; GO:0016032 "ATPase activity; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G1/S transition of mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic process; cytosol; gene expression; mRNA metabolic process; negative regulation of apoptotic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; proteasome accessory complex; protein polyubiquitination; regulation of cellular amino acid metabolic process; viral process" IPR019585; IPR000717; IPR011991; 26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A) PSMD6 KIAA0107 PFAAP4 Homo sapiens (Human) TR12782_c0_g1_i1 Q9NYU1 UGGG2_HUMAN 9.00E-16 GO:0003980; GO:0005788; GO:0005793; GO:0043687; GO:0018279; GO:0006457 UDP-glucose:glycoprotein glucosyltransferase activity; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment; post-translational protein modification; protein N-linked glycosylation via asparagine; protein folding IPR002495; IPR009448; Protein modification; protein glycosylation. UDP-glucose:glycoprotein glucosyltransferase 2 (UGT2) (hUGT2) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase 2) (UDP-glucose ceramide glucosyltransferase-like 1) UGGT2 UGCGL2 UGT2 Homo sapiens (Human) TR12784_c0_g1_i1 Q9NY64 GTR8_HUMAN 7.00E-58 GO:0005975; GO:0030659; GO:0005536; GO:0005355; GO:0008286; GO:0005887; GO:0005765; GO:0007141; GO:0001666; GO:0008021 carbohydrate metabolic process; cytoplasmic vesicle membrane; glucose binding; glucose transmembrane transporter activity; insulin receptor signaling pathway; integral to plasma membrane; lysosomal membrane; male meiosis I; response to hypoxia; synaptic vesicle IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 8 (Glucose transporter type 8) (GLUT-8) (Glucose transporter type X1)" SLC2A8 GLUT8 GLUTX1 Homo sapiens (Human) TR12789_c0_g1_i1 P59034 LRRC3_MOUSE 4.00E-10 GO:0016021 integral to membrane IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing protein 3 Lrrc3 Mus musculus (Mouse) TR12795_c0_g1_i1 P08472 M130_STRPU 1.00E-05 GO:0031225; GO:0016787; GO:0009166; GO:0005886 anchored to membrane; hydrolase activity; nucleotide catabolic process; plasma membrane IPR006179; IPR015943; Mesenchyme-specific cell surface glycoprotein (MSP130) Strongylocentrotus purpuratus (Purple sea urchin) TR12801_c0_g1_i1 P09648 CATL1_CHICK 9.00E-36 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; Cathepsin L1 (EC 3.4.22.15) (Cathepsin L) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain] (Fragments) CTSL CTSL1 Gallus gallus (Chicken) TR12802_c0_g1_i1 Q03350 TSP2_MOUSE 3.00E-10 GO:0005604; GO:0005509; GO:0007155; GO:0008201; GO:0016525 Q63722; Q07954 basement membrane; calcium ion binding; cell adhesion; heparin binding; negative regulation of angiogenesis IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR024731; IPR001791; IPR000884; IPR015455; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-2 Thbs2 Tsp2 Mus musculus (Mouse) TR12802_c1_g1_i1 P35441 TSP1_MOUSE 1.00E-08 GO:0048266; GO:0048514; GO:0005509; GO:0007155; GO:0003197; GO:0050840; GO:0005615; GO:0003417; GO:0008201; GO:0006954; GO:0016525; GO:0003151; GO:0010811; GO:0010759; GO:0030511; GO:0034976; GO:0016529 behavioral response to pain; blood vessel morphogenesis; calcium ion binding; cell adhesion; endocardial cushion development; extracellular matrix binding; extracellular space; growth plate cartilage development; heparin binding; inflammatory response; negative regulation of angiogenesis; outflow tract morphogenesis; positive regulation of cell-substrate adhesion; positive regulation of macrophage chemotaxis; positive regulation of transforming growth factor beta receptor signaling pathway; response to endoplasmic reticulum stress; sarcoplasmic reticulum IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR001791; IPR000884; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-1 Thbs1 Tsp1 Mus musculus (Mouse) TR12806_c0_g1_i1 Q03278 PO21_NASVI 7.00E-06 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR000477; IPR007087; IPR015880; Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 (Retrovirus-related Pol polyprotein from type I retrotransposable element R2) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] (Fragment) Nasonia vitripennis (Parasitic wasp) TR12823_c0_g2_i1 Q53CG2 COX7C_MACSL 3.00E-14 GO:0004129; GO:0016021; GO:0005743 cytochrome-c oxidase activity; integral to membrane; mitochondrial inner membrane IPR004202; "Cytochrome c oxidase subunit 7C, mitochondrial (Cytochrome c oxidase polypeptide VIIc)" COX7C Macaca silenus (Lion-tailed macaque) TR12826_c0_g1_i1 P49065 ALBU_RABIT 6.00E-71 GO:0003677; GO:0009267; GO:0008144; GO:0005615; GO:0005504; GO:0019836; GO:0051659; GO:0046872; GO:0043066; GO:0043234; GO:0030170; GO:0015643; GO:0006810 DNA binding; cellular response to starvation; drug binding; extracellular space; fatty acid binding; hemolysis by symbiont of host erythrocytes; maintenance of mitochondrion location; metal ion binding; negative regulation of apoptotic process; protein complex; pyridoxal phosphate binding; toxic substance binding; transport IPR000264; IPR001703; IPR020858; IPR021177; IPR020857; IPR014760; Serum albumin ALB Oryctolagus cuniculus (Rabbit) TR12826_c1_g1_i1 P21848 ALBU1_SALSA 8.00E-08 GO:0005615; GO:0008289; GO:0046872; GO:0006810 extracellular space; lipid binding; metal ion binding; transport IPR000264; IPR020858; IPR021177; IPR020857; IPR014760; Serum albumin 1 alb1 Salmo salar (Atlantic salmon) TR12846_c0_g1_i1 Q9WV25 PUF60_RAT 2.00E-12 GO:0003677; GO:0003723; GO:0008380; GO:0006915; GO:0019907; GO:0006397; GO:0000166; GO:0006355; GO:0030529; GO:0006351 "DNA binding; RNA binding; RNA splicing; apoptotic process; cyclin-dependent protein kinase activating kinase holoenzyme complex; mRNA processing; nucleotide binding; regulation of transcription, DNA-dependent; ribonucleoprotein complex; transcription, DNA-dependent" IPR012677; IPR006532; IPR000504; Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (RNA-binding protein Siah-BP) (Siah-binding protein 1) Puf60 Siahbp1 Rattus norvegicus (Rat) TR12847_c1_g1_i1 Q8IW92 GLBL2_HUMAN 6.00E-24 GO:0004565; GO:0005975; GO:0005576 beta-galactosidase activity; carbohydrate metabolic process; extracellular region IPR026283; IPR008979; IPR019801; IPR013781; IPR001944; IPR017853; Beta-galactosidase-1-like protein 2 (EC 3.2.1.-) GLB1L2 MSTP014 UNQ210/PRO236 Homo sapiens (Human) TR12858_c0_g1_i1 Q07954 LRP1_HUMAN 8.00E-14 GO:0035909; GO:0034185; GO:0043277; GO:0097242; GO:0005509; GO:0008203; GO:0005905; GO:0030666; GO:0005887; GO:0070325; GO:0042954; GO:0005765; GO:0030178; GO:2000587; GO:0014912; GO:0005634; GO:0007603; GO:0010875; GO:0032403; GO:0004872; GO:0006898; GO:0032956; GO:0032429; GO:0001523 O00213; Q15485; Q63722; P11226; Q03350 "aorta morphogenesis; apolipoprotein binding; apoptotic cell clearance; beta-amyloid clearance; calcium ion binding; cholesterol metabolic process; coated pit; endocytic vesicle membrane; integral to plasma membrane; lipoprotein particle receptor binding; lipoprotein transporter activity; lysosomal membrane; negative regulation of Wnt receptor signaling pathway; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; negative regulation of smooth muscle cell migration; nucleus; phototransduction, visible light; positive regulation of cholesterol efflux; protein complex binding; receptor activity; receptor-mediated endocytosis; regulation of actin cytoskeleton organization; regulation of phospholipase A2 activity; retinoid metabolic process" IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)] LRP1 A2MR APR Homo sapiens (Human) TR12861_c1_g1_i1 Q16KN5 RETM_AEDAE 3.00E-17 GO:0016021; GO:0005739; GO:0006810 integral to membrane; mitochondrion; transport IPR001251; IPR011074; IPR009038; IPR006797; Protein real-time retm AAEL012929 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR12861_c1_g2_i1 Q92503 S14L1_HUMAN 1.00E-50 GO:0005794; GO:0016021; GO:0016020; GO:0006810 Golgi apparatus; integral to membrane; membrane; transport IPR001251; IPR011074; IPR009038; IPR006797; SEC14-like protein 1 SEC14L1 SEC14L Homo sapiens (Human) TR12869_c1_g1_i1 Q6UB98 ANR12_HUMAN 1.00E-07 GO:0005737; GO:0005634 cytoplasm; nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) ANKRD12 ANCO2 KIAA0874 Homo sapiens (Human) TR12878_c0_g1_i1 O75369 FLNB_HUMAN 9.00E-34 GO:0030018; GO:0003779; GO:0015629; GO:0030036; GO:0005938; GO:0030154; GO:0019221; GO:0007016; GO:0005829; GO:0005925; GO:0016021; GO:0005886; GO:0007519; GO:0001725 Itself; P21333; P62993; P05161; Q13233; Q9Y6R4; P16333; P63000 Z disc; actin binding; actin cytoskeleton; actin cytoskeleton organization; cell cortex; cell differentiation; cytokine-mediated signaling pathway; cytoskeletal anchoring at plasma membrane; cytosol; focal adhesion; integral to membrane; plasma membrane; skeletal muscle tissue development; stress fiber IPR001589; IPR001715; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) FLNB FLN1L FLN3 TABP TAP Homo sapiens (Human) TR12886_c0_g1_i1 Q9R044 NPHN_RAT 2.00E-06 GO:0007155; GO:0003094; GO:0016021; GO:0045121; GO:0007517; GO:0005886; GO:0043234; GO:0036057 P97710 cell adhesion; glomerular filtration; integral to membrane; membrane raft; muscle organ development; plasma membrane; protein complex; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Rattus norvegicus (Rat) TR12892_c0_g1_i1 Q8BVD5 MPP7_MOUSE 9.00E-22 GO:0097025; GO:0031334; GO:0032947; GO:0019904; GO:0046982; GO:0071896; GO:0005923; GO:0070830 MPP7-DLG1-LIN7 complex; positive regulation of protein complex assembly; protein complex scaffold; protein domain specific binding; protein heterodimerization activity; protein localization to adherens junction; tight junction; tight junction assembly IPR008145; IPR008144; IPR020590; IPR004172; IPR014775; IPR027417; IPR001478; IPR011511; IPR001452; MAGUK p55 subfamily member 7 Mpp7 Mus musculus (Mouse) TR12896_c2_g1_i1 Q0VB07 PGRP4_MOUSE 5.00E-11 GO:0008745; GO:0042742; GO:0005576; GO:0044117; GO:0045087; GO:0032689; GO:0032827; GO:0042834; GO:0009253; GO:0008270 N-acetylmuramoyl-L-alanine amidase activity; defense response to bacterium; extracellular region; growth of symbiont in host; innate immune response; negative regulation of interferon-gamma production; negative regulation of natural killer cell differentiation involved in immune response; peptidoglycan binding; peptidoglycan catabolic process; zinc ion binding IPR002502; IPR015510; IPR006619; Peptidoglycan recognition protein 4 (Peptidoglycan recognition protein I-beta) (PGLYRPIbeta) (PGRP-I-beta) (Peptidoglycan recognition protein intermediate beta) Pglyrp4 Pgrpib Mus musculus (Mouse) TR1290_c0_g1_i1 Q501Z5 GTPB3_DANRE 4.00E-17 GO:0005525; GO:0003924; GO:0005739; GO:0006400 GTP binding; GTPase activity; mitochondrion; tRNA modification IPR018948; IPR006073; IPR004520; IPR025867; IPR027368; IPR027417; IPR005225; IPR027266; "tRNA modification GTPase GTPBP3, mitochondrial (GTP-binding protein 3)" gtpbp3 zgc:112394 Danio rerio (Zebrafish) (Brachydanio rerio) TR12905_c0_g1_i1 Q5BJE1 CR034_HUMAN 1.00E-12 Coiled-coil domain-containing protein 178 CCDC178 C18orf34 Homo sapiens (Human) TR12914_c0_g1_i1 Q5DU56 NLRC3_MOUSE 2.00E-13 GO:0005524; GO:0007249; GO:0042110; GO:0005737; GO:0043124; GO:0032088; GO:0031396; GO:0032496 ATP binding; I-kappaB kinase/NF-kappaB cascade; T cell activation; cytoplasm; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of NF-kappaB transcription factor activity; regulation of protein ubiquitination; response to lipopolysaccharide IPR007111; IPR027417; Protein NLRC3 Nlrc3 Mus musculus (Mouse) TR12925_c2_g1_i1 P91252 GST6_CAEEL 1.00E-07 GO:0004364 glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Probable glutathione S-transferase 6 (EC 2.5.1.18) (GST class-sigma) gst-6 F11G11.3 Caenorhabditis elegans TR12931_c1_g1_i1 Q63170 DYH7_RAT 1.00E-120 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0005509; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; calcium ion binding; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR026983; IPR026979; IPR024743; IPR024317; IPR004273; IPR013602; IPR018247; IPR002048; IPR027417; "Dynein heavy chain 7, axonemal (Axonemal beta dynein heavy chain 7) (Axonemal dynein heavy chain b) (Ciliary dynein heavy chain 7) (Dynein-like protein 7)" Dnah7 Axob Dlp7 Rattus norvegicus (Rat) TR12933_c1_g1_i1 Q96MM6 HS12B_HUMAN 2.00E-06 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR12935_c1_g1_i1 Q10998 CP1_APLCA 2.00E-23 GO:0005576 extracellular region Cerebral peptide 1 (CP1) (Connecting peptide 3) (CP3) [Cleaved into: APGW-amide; Cerebral peptide 1 (CP1); C-terminal peptide (CTP)] Aplysia californica (California sea hare) TR12939_c1_g1_i1 P41383 TBA2_PATVU 6.00E-107 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-2/alpha-4 chain TUB2; TUB4 Patella vulgata (Common limpet) TR12942_c1_g1_i1 P86858 MYT2_MYTCA 1.00E-18 GO:0005576 extracellular region Mytilin-2 (Mytilus uncharacterized protein 2) (MUSP-2) Mytilus californianus (California mussel) TR12943_c0_g1_i1 Q09103 DGK2_DROME 1.00E-11 GO:0005524; GO:0003951; GO:0007015; GO:0016059; GO:0004143; GO:0035556; GO:0046834; GO:0016020; GO:0046872; GO:0005875; GO:0006654; GO:0006661; GO:0045494; GO:0007205; GO:0016056; GO:0007608; GO:0007605; GO:0043052; GO:0007601 ATP binding; NAD+ kinase activity; actin filament organization; deactivation of rhodopsin mediated signaling; diacylglycerol kinase activity; intracellular signal transduction; lipid phosphorylation; membrane; metal ion binding; microtubule associated complex; phosphatidic acid biosynthetic process; phosphatidylinositol biosynthetic process; photoreceptor cell maintenance; protein kinase C-activating G-protein coupled receptor signaling pathway; rhodopsin mediated signaling pathway; sensory perception of smell; sensory perception of sound; thermotaxis; visual perception IPR002110; IPR020683; IPR016064; IPR000756; IPR001206; IPR002219; Eye-specific diacylglycerol kinase (DAG kinase 2) (DGK 2) (Diglyceride kinase 2) (EC 2.7.1.107) (Retinal degeneration A protein) rdgA DGK2 CG34344 Drosophila melanogaster (Fruit fly) TR12948_c0_g1_i1 Q9ULJ7 ANR50_HUMAN 1.00E-28 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) TR12953_c1_g1_i1 P49756 RBM25_HUMAN 1.00E-49 GO:0008380; GO:0005737; GO:0097194; GO:0003729; GO:0006397; GO:0016607; GO:0000166; GO:0000381 "RNA splicing; cytoplasm; execution phase of apoptosis; mRNA binding; mRNA processing; nuclear speck; nucleotide binding; regulation of alternative mRNA splicing, via spliceosome" IPR012677; IPR002483; IPR000504; RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) RBM25 RNPC7 Homo sapiens (Human) TR12967_c1_g1_i1 P62925 IF5A_SPOFR 2.00E-26 GO:0005737; GO:0008612; GO:0045901; GO:0045905; GO:0043022; GO:0003746; GO:0006452 cytoplasm; peptidyl-lysine modification to hypusine; positive regulation of translational elongation; positive regulation of translational termination; ribosome binding; translation elongation factor activity; translational frameshifting IPR012340; IPR014722; IPR019769; IPR001884; IPR020189; IPR008991; Eukaryotic translation initiation factor 5A (eIF-5A) eIF-5A eIF5A Spodoptera frugiperda (Fall armyworm) TR12979_c0_g1_i1 Q3UHD1 BAI1_MOUSE 4.00E-15 GO:0004930; GO:0016021; GO:0016525; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; negative regulation of angiogenesis; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR008077; IPR001879; IPR000832; IPR000203; IPR000884; Brain-specific angiogenesis inhibitor 1 Bai1 Mus musculus (Mouse) TR12984_c1_g1_i1 Q8WXX0 DYH7_HUMAN 1.00E-44 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0005509; GO:0001539; GO:0005929; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; calcium ion binding; ciliary or bacterial-type flagellar motility; cilium; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR026983; IPR026979; IPR024743; IPR024317; IPR004273; IPR013602; IPR018247; IPR002048; IPR027417; "Dynein heavy chain 7, axonemal (Axonemal beta dynein heavy chain 7) (Ciliary dynein heavy chain 7) (Dynein heavy chain-like protein 2) (hDHC2)" DNAH7 KIAA0944 Homo sapiens (Human) TR12986_c2_g1_i1 Q91VL8 TE2IP_MOUSE 9.00E-06 GO:0003677; GO:0030870; GO:0005737; GO:0048239; GO:0032205; GO:0000784; GO:0000783; GO:0005654; GO:0043123; GO:0051092; GO:0070198; GO:0010569; GO:0010833; GO:0006351 "DNA binding; Mre11 complex; cytoplasm; negative regulation of DNA recombination at telomere; negative regulation of telomere maintenance; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleoplasm; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; protein localization to chromosome, telomeric region; regulation of double-strand break repair via homologous recombination; telomere maintenance via telomere lengthening; transcription, DNA-dependent" IPR009057; IPR021661; IPR015010; Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Repressor/activator protein 1 homolog) (RAP1 homolog) Terf2ip Rap1 MNCb-0448 MNCb-0628 Mus musculus (Mouse) TR1299_c0_g1_i1 A0JM12 MEG10_XENTR 9.00E-10 GO:0007155; GO:0016021; GO:0006909; GO:0005886; GO:0014719; GO:0014816; GO:0014841 cell adhesion; integral to membrane; phagocytosis; plasma membrane; satellite cell activation; satellite cell differentiation; satellite cell proliferation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR12994_c0_g1_i1 P11369 POL2_MOUSE 9.00E-06 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR013544; IPR005135; IPR000477; Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element-1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] Pol Gm17492 Mus musculus (Mouse) TR12996_c0_g2_i1 P80035 LIPG_CANFA 3.00E-92 GO:0005576; GO:0016042; GO:0004806 extracellular region; lipid catabolic process; triglyceride lipase activity IPR000073; IPR006693; IPR025483; Gastric triacylglycerol lipase (GL) (Gastric lipase) (EC 3.1.1.3) LIPF Canis familiaris (Dog) (Canis lupus familiaris) TR13008_c0_g1_i1 Q7YR75 RM12_BOVIN 8.00E-28 GO:0005762; GO:0003735; GO:0006412 mitochondrial large ribosomal subunit; structural constituent of ribosome; translation IPR014719; IPR013823; IPR008932; "39S ribosomal protein L12, mitochondrial (L12mt) (MRP-L12)" MRPL12 Bos taurus (Bovine) TR13017_c0_g1_i1 Q9NP78 ABCB9_HUMAN 2.00E-28 GO:0005524; GO:0042288; GO:0042825; GO:0046978; GO:0046979; GO:0005765; GO:0015421; GO:0042605; GO:0005886; GO:0001916; GO:0042803; GO:0015031; GO:0046980 ATP binding; MHC class I protein binding; TAP complex; TAP1 binding; TAP2 binding; lysosomal membrane; oligopeptide-transporting ATPase activity; peptide antigen binding; plasma membrane; positive regulation of T cell mediated cytotoxicity; protein homodimerization activity; protein transport; tapasin binding IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; ATP-binding cassette sub-family B member 9 (ATP-binding cassette transporter 9) (ABC transporter 9 protein) (hABCB9) (TAP-like protein) (TAPL) ABCB9 KIAA1520 Homo sapiens (Human) TR13019_c2_g1_i1 Q91Z46 DUS7_MOUSE 7.00E-83 GO:0017017; GO:0005829; GO:0006470; GO:0004725 MAP kinase tyrosine/serine/threonine phosphatase activity; cytosol; protein dephosphorylation; protein tyrosine phosphatase activity IPR000340; IPR020422; IPR024950; IPR008343; IPR001763; IPR000387; Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) Dusp7 Mus musculus (Mouse) TR13022_c0_g2_i1 Q20191 NAS13_CAEEL 2.00E-06 GO:0005576; GO:0004222; GO:0006508; GO:0008270 extracellular region; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR001506; IPR006026; IPR003582; Zinc metalloproteinase nas-13 (EC 3.4.24.21) (Nematode astacin 13) nas-13 F39D8.4 Caenorhabditis elegans TR13030_c1_g1_i1 O43301 HS12A_HUMAN 3.00E-30 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR13035_c0_g2_i1 Q8K1S3 UNC5B_MOUSE 4.00E-13 GO:0033564; GO:0006915; GO:0005829; GO:0016021; GO:2001240; GO:0005886; GO:0007165 Q7TNP2 anterior/posterior axon guidance; apoptotic process; cytosol; integral to membrane; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; plasma membrane; signal transduction IPR011029; IPR000488; IPR007110; IPR013783; IPR013098; IPR003598; IPR000884; IPR000906; Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) Unc5b Unc5h2 Mus musculus (Mouse) TR13039_c0_g1_i1 Q86Z23 C1QL4_HUMAN 1.00E-06 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) C1QL4 CTRP11 Homo sapiens (Human) TR13046_c0_g1_i1 Q8MQJ9 BRAT_DROME 5.00E-14 GO:0008356; GO:0055060; GO:0007411; GO:0007420; GO:0005737; GO:0007402; GO:0007406; GO:0048477; GO:0006909; GO:0009303; GO:0035282; GO:0030371; GO:0008270 asymmetric cell division; asymmetric neuroblast division resulting in ganglion mother cell formation; axon guidance; brain development; cytoplasm; ganglion mother cell fate determination; negative regulation of neuroblast proliferation; oogenesis; phagocytosis; rRNA transcription; segmentation; translation repressor activity; zinc ion binding IPR011042; IPR001258; IPR013017; IPR000315; Brain tumor protein brat CG10719 Drosophila melanogaster (Fruit fly) TR13047_c0_g1_i1 Q00780 CO8A1_MOUSE 3.00E-07 GO:0001525; GO:0005604; GO:0048593; GO:0007155; GO:0005581; GO:0050673; GO:0010811 angiogenesis; basement membrane; camera-type eye morphogenesis; cell adhesion; collagen; epithelial cell proliferation; positive regulation of cell-substrate adhesion IPR001073; IPR008160; IPR008983; Collagen alpha-1(VIII) chain [Cleaved into: Vastatin] Col8a1 Mus musculus (Mouse) TR13049_c1_g1_i1 Q6PBC1 RL35_XENTR 1.00E-24 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001854; IPR018254; 60S ribosomal protein L35 rpl35 TGas044l18.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR13054_c1_g1_i1 A8DYE2 TRPCG_DROME 2.00E-09 GO:0005261; GO:0034703; GO:0016049; GO:0070838; GO:0010960; GO:0046873; GO:0007005; GO:0055069 cation channel activity; cation channel complex; cell growth; divalent metal ion transport; magnesium ion homeostasis; metal ion transmembrane transporter activity; mitochondrion organization; zinc ion homeostasis IPR005821; Transient receptor potential cation channel trpm trpm CG44240 Drosophila melanogaster (Fruit fly) TR13058_c1_g1_i1 Q9TT16 CLCN6_RABIT 5.00E-62 GO:0005524; GO:0015297; GO:0010008; GO:0016021; GO:0005247 ATP binding; antiporter activity; endosome membrane; integral to membrane; voltage-gated chloride channel activity IPR000644; IPR014743; IPR001807; IPR002248; Chloride transport protein 6 (Chloride channel protein 6) (ClC-6) CLCN6 Oryctolagus cuniculus (Rabbit) TR13060_c0_g1_i1 A2RT62 FXL16_MOUSE 3.00E-31 IPR001810; F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16) Fbxl16 Mus musculus (Mouse) TR13061_c0_g1_i1 E1C2I2 GWL_CHICK 4.00E-32 GO:0005524; GO:0000086; GO:0051301; GO:0005813; GO:0032154; GO:0005737; GO:0007067; GO:0034048; GO:0005634; GO:0051721; GO:0004674; GO:0051726; GO:0006974 ATP binding; G2/M transition of mitotic cell cycle; cell division; centrosome; cleavage furrow; cytoplasm; mitosis; negative regulation of protein phosphatase type 2A activity; nucleus; protein phosphatase 2A binding; protein serine/threonine kinase activity; regulation of cell cycle; response to DNA damage stimulus IPR000961; IPR011009; IPR000719; IPR008271; Serine/threonine-protein kinase greatwall (GW) (GWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) MASTL GW GWL Gallus gallus (Chicken) TR13073_c0_g1_i1 Q8R422 CD109_MOUSE 1.00E-14 GO:0031225; GO:0005615; GO:0010951; GO:0005886; GO:0004867 anchored to membrane; extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; CD109 antigen (GPI-anchored alpha-2 macroglobulin-related protein) (CD antigen CD109) Cd109 Mus musculus (Mouse) TR13076_c2_g1_i1 Q9I919 GPR85_DANRE 6.00E-10 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR000276; IPR017452; Probable G protein-coupled receptor 85 (Super conserved receptor expressed in brain 2) (zSREB2) gpr85 sreb2 si:dkey-223l3.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR13080_c0_g1_i1 Q5UPG5 YL093_MIMIV 3.00E-15 IPR002110; IPR020683; Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) TR13083_c0_g1_i1 P18933 NU6M_DROME 6.00E-08 GO:0008137; GO:0016021; GO:0031966; GO:0070469 NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial membrane; respiratory chain IPR001457; NADH-ubiquinone oxidoreductase chain 6 (EC 1.6.5.3) (NADH dehydrogenase subunit 6) mt:ND6 ND6 Drosophila melanogaster (Fruit fly) TR13084_c0_g1_i1 P14381 YTX2_XENLA 1.00E-08 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR13086_c0_g1_i1 Q641K1 CBPC1_MOUSE 1.00E-11 GO:0035609; GO:0007628; GO:0008219; GO:0021702; GO:0005829; GO:0001754; GO:0004181; GO:0005739; GO:0007005; GO:0050905; GO:0042133; GO:0005634; GO:0021772; GO:0035610; GO:0006508; GO:0060041; GO:0015631; GO:0008270 C-terminal protein deglutamylation; adult walking behavior; cell death; cerebellar Purkinje cell differentiation; cytosol; eye photoreceptor cell differentiation; metallocarboxypeptidase activity; mitochondrion; mitochondrion organization; neuromuscular process; neurotransmitter metabolic process; nucleus; olfactory bulb development; protein side chain deglutamylation; proteolysis; retina development in camera-type eye; tubulin binding; zinc ion binding IPR011989; IPR016024; IPR000834; Cytosolic carboxypeptidase 1 (EC 3.4.17.-) (ATP/GTP-binding protein 1) (Nervous system nuclear protein induced by axotomy protein 1) Agtpbp1 Ccp1 Nna1 Mus musculus (Mouse) TR13090_c0_g1_i1 P38977 ANTA_HYDVU 1.00E-12 GO:0007596; GO:0005576; GO:0008201; GO:0004867 blood coagulation; extracellular region; heparin binding; serine-type endopeptidase inhibitor activity IPR004094; IPR011061; Antistasin (ATS) (Blood coagulation factor Xa/proclotting enzyme inhibitor) Hydra vulgaris (Hydra) (Hydra attenuata) TR13090_c0_g1_i2 P38977 ANTA_HYDVU 6.00E-13 GO:0007596; GO:0005576; GO:0008201; GO:0004867 blood coagulation; extracellular region; heparin binding; serine-type endopeptidase inhibitor activity IPR004094; IPR011061; Antistasin (ATS) (Blood coagulation factor Xa/proclotting enzyme inhibitor) Hydra vulgaris (Hydra) (Hydra attenuata) TR13094_c0_g1_i1 Q9BXX0 EMIL2_HUMAN 1.00E-09 GO:0007155; GO:0005581; GO:0030023; GO:0005576 cell adhesion; collagen; extracellular matrix constituent conferring elasticity; extracellular region IPR001073; IPR011489; IPR008983; EMILIN-2 (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10) EMILIN2 Homo sapiens (Human) TR13103_c0_g1_i1 Q96ST8 CEP89_HUMAN 6.00E-08 GO:0005814; GO:0042384; GO:0005829; GO:0005758; GO:0005886; GO:0000922 centriole; cilium assembly; cytosol; mitochondrial intermembrane space; plasma membrane; spindle pole Centrosomal protein of 89 kDa (Cep89) (Coiled-coil domain-containing protein 123) CEP89 CCDC123 Homo sapiens (Human) TR13115_c0_g2_i1 Q6NUB3 S22AF_XENLA 1.00E-16 GO:0016021; GO:0006811; GO:0022857 integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Solute carrier family 22 member 15 slc22a15 Xenopus laevis (African clawed frog) TR13115_c1_g1_i1 Q9VCA2 ORCT_DROME 5.00E-30 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR13116_c0_g1_i1 P90789 NDUB7_CAEEL 5.00E-21 GO:0008137; GO:0005743; GO:0005758; GO:0070469 NADH dehydrogenase (ubiquinone) activity; mitochondrial inner membrane; mitochondrial intermembrane space; respiratory chain IPR008698; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 D2030.4 Caenorhabditis elegans TR13121_c0_g1_i1 P49065 ALBU_RABIT 6.00E-41 GO:0003677; GO:0009267; GO:0008144; GO:0005615; GO:0005504; GO:0019836; GO:0051659; GO:0046872; GO:0043066; GO:0043234; GO:0030170; GO:0015643; GO:0006810 DNA binding; cellular response to starvation; drug binding; extracellular space; fatty acid binding; hemolysis by symbiont of host erythrocytes; maintenance of mitochondrion location; metal ion binding; negative regulation of apoptotic process; protein complex; pyridoxal phosphate binding; toxic substance binding; transport IPR000264; IPR001703; IPR020858; IPR021177; IPR020857; IPR014760; Serum albumin ALB Oryctolagus cuniculus (Rabbit) TR13128_c2_g1_i1 Q8C190 CP007_MOUSE 1.00E-09 GO:0005737; GO:0005634 cytoplasm; nucleus IPR003123; VPS9 domain-containing protein 1 (5-day ovary-specific transcript 1 protein) Vps9d1 Mus musculus (Mouse) TR13133_c0_g1_i1 Q64512 PTN13_MOUSE 4.00E-09 GO:0005737; GO:0005856; GO:0030027; GO:0005634; GO:0004725 O88665 cytoplasm; cytoskeleton; lamellipodium; nucleus; protein tyrosine phosphatase activity IPR019749; IPR019750; IPR014352; IPR019748; IPR000299; IPR018979; IPR018980; IPR011019; IPR001478; IPR011993; IPR000387; IPR012153; IPR000242; Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (PTP36) (Protein tyrosine phosphatase DPZPTP) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) Ptpn13 Ptp14 Mus musculus (Mouse) TR13140_c0_g1_i1 Q9QZQ1 AFAD_MOUSE 3.00E-06 GO:0045177; GO:0007155; GO:0005913; GO:0005737; GO:0007165 apical part of cell; cell adhesion; cell-cell adherens junction; cytoplasm; signal transduction IPR018444; IPR002710; IPR000253; IPR001478; IPR000159; IPR008984; Afadin (Protein Af-6) Mllt4 Af6 Mus musculus (Mouse) TR13140_c1_g1_i1 B7ZC32 KLP6_HUMAN 2.00E-42 GO:0005524; GO:0005871; GO:0003777; GO:0031966; GO:0007005; GO:0072384 ATP binding; kinesin complex; microtubule motor activity; mitochondrial membrane; mitochondrion organization; organelle transport along microtubule IPR000253; IPR022140; IPR027640; IPR001752; IPR027417; IPR008984; Kinesin-like protein KLP6 (Kinesin-like protein 6) KLP6 Homo sapiens (Human) TR13141_c1_g1_i1 Q3TDN0 DISP1_MOUSE 4.00E-22 GO:0007368; GO:0060539; GO:0009953; GO:0009880; GO:0008158; GO:0016021; GO:0007225; GO:0015197; GO:0007224 determination of left/right symmetry; diaphragm development; dorsal/ventral pattern formation; embryonic pattern specification; hedgehog receptor activity; integral to membrane; patched ligand maturation; peptide transporter activity; smoothened signaling pathway IPR003392; IPR000731; Protein dispatched homolog 1 (Mdispa) Disp1 Disp Dispa Icb Icbins Mus musculus (Mouse) TR13151_c2_g1_i1 Q61212 NPY6R_MOUSE 2.00E-09 GO:0016021; GO:0001601; GO:0005886 integral to membrane; peptide YY receptor activity; plasma membrane IPR000276; IPR017452; IPR000986; IPR000611; Neuropeptide Y receptor type 6 (NPY6-R) (Pancreatic polypeptide receptor 2) (PP2) Npy6r Npy5r Ppyr2 Y2b Mus musculus (Mouse) TR13156_c2_g1_i1 O02827 MYLK_SHEEP 3.00E-11 GO:0005524; GO:0032154; GO:0005737; GO:0005856; GO:0030027; GO:0046872; GO:0004687 ATP binding; cleavage furrow; cytoplasm; cytoskeleton; lamellipodium; metal ion binding; myosin light chain kinase activity IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR020675; IPR000719; IPR002290; IPR008271; "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] (Fragment)" MYLK Ovis aries (Sheep) TR13157_c0_g1_i1 P12938 CP2D3_RAT 2.00E-17 GO:0070330; GO:0005789; GO:0020037; GO:0005506; GO:0001889; GO:0004497 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding; liver development; monooxygenase activity IPR001128; IPR017972; IPR002401; IPR008069; Cytochrome P450 2D3 (EC 1.14.14.1) (CYPIID3) (Cytochrome P450-DB3) (Debrisoquine 4-hydroxylase) Cyp2d3 Cyp2d-3 Rattus norvegicus (Rat) TR13171_c0_g1_i1 Q9UMN6 MLL4_HUMAN 2.00E-26 GO:0003677; GO:0048096; GO:0016458; GO:0080182; GO:0042800; GO:0035097; GO:0009994; GO:0001541; GO:0030728; GO:0051569; GO:0003700; GO:0006351; GO:0008270 P16333 "DNA binding; chromatin-mediated maintenance of transcription; gene silencing; histone H3-K4 trimethylation; histone methyltransferase activity (H3-K4 specific); histone methyltransferase complex; oocyte differentiation; ovarian follicle development; ovulation; regulation of histone H3-K4 methylation; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR017956; IPR003889; IPR003888; IPR016569; IPR003616; IPR001214; IPR002857; IPR011011; IPR001965; IPR019787; IPR013083; Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.43) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) KMT2B HRX2 KIAA0304 MLL2 MLL4 TRX2 WBP7 Homo sapiens (Human) TR13172_c1_g1_i1 Q9GL24 CATL1_CANFA 1.00E-16 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L1 (EC 3.4.22.15) (Cathepsin L) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain] CTSL CTSL1 Canis familiaris (Dog) (Canis lupus familiaris) TR13178_c0_g2_i1 Q9VLM5 DAD1_DROME 2.00E-56 GO:0006915; GO:0004579; GO:0016021; GO:0008250; GO:0006486 apoptotic process; dolichyl-diphosphooligosaccharide-protein glycotransferase activity; integral to membrane; oligosaccharyltransferase complex; protein glycosylation IPR003038; Protein modification; protein glycosylation. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (DAD-1) (Defender against cell death 1) (Oligosaccharyl transferase subunit DAD1) (EC 2.4.99.18) CG13393 Drosophila melanogaster (Fruit fly) TR13184_c0_g1_i1 Q1EG27 MYO3B_MOUSE 6.00E-11 GO:0005524; GO:0005737; GO:0032433; GO:0000146; GO:0016459; GO:0018105; GO:0018107; GO:0001917; GO:0001750; GO:0051491; GO:0046777; GO:0004674; GO:0050896; GO:0032426; GO:0007601 ATP binding; cytoplasm; filopodium tip; microfilament motor activity; myosin complex; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; photoreceptor inner segment; photoreceptor outer segment; positive regulation of filopodium assembly; protein autophosphorylation; protein serine/threonine kinase activity; response to stimulus; stereocilium bundle tip; visual perception IPR000048; IPR011009; IPR001609; IPR027417; IPR000719; IPR017441; IPR002290; IPR008271; Myosin-IIIb (EC 2.7.11.1) Myo3b Mus musculus (Mouse) TR13188_c0_g1_i1 Q5T619 ZN648_HUMAN 1.00E-07 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 648 ZNF648 Homo sapiens (Human) TR13190_c0_g2_i1 Q6INN8 SAMH1_XENLA 1.00E-18 GO:0003723; GO:0051607; GO:0045087; GO:0008152; GO:0046872; GO:0005634; GO:0008081; GO:0045088 RNA binding; defense response to virus; innate immune response; metabolic process; metal ion binding; nucleus; phosphoric diester hydrolase activity; regulation of innate immune response IPR003607; IPR006674; IPR001660; IPR013761; IPR011510; Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) samhd1 Xenopus laevis (African clawed frog) TR13194_c2_g1_i1 O15553 MEFV_HUMAN 4.00E-07 GO:0003779; GO:0005829; GO:0006954; GO:0045087; GO:0005874; GO:0005875; GO:0050728; GO:0032691; GO:0032695; GO:0071641; GO:0035872; GO:0005634; GO:2001056; GO:0008270 "actin binding; cytosol; inflammatory response; innate immune response; microtubule; microtubule associated complex; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-12 production; negative regulation of macrophage inflammatory protein 1 alpha production; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; nucleus; positive regulation of cysteine-type endopeptidase activity; zinc ion binding" IPR001870; IPR003879; IPR008985; IPR004020; IPR011029; IPR006574; IPR018355; IPR003877; IPR000315; Pyrin (Marenostrin) MEFV MEF Homo sapiens (Human) TR13206_c0_g2_i1 Q7Z5L3 C1QL2_HUMAN 4.00E-08 GO:0005581; GO:0051259 collagen; protein oligomerization IPR001073; IPR008160; IPR008983; Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) TR1321_c0_g1_i1 P16395 ACM1_DROME 7.00E-12 GO:0016907; GO:0030054; GO:0005887; GO:0007200; GO:0045211 G-protein coupled acetylcholine receptor activity; cell junction; integral to plasma membrane; phospholipase C-activating G-protein coupled receptor signaling pathway; postsynaptic membrane IPR000276; IPR017452; IPR000995; Muscarinic acetylcholine receptor DM1 mAcR-60C AcrC CG4356 Drosophila melanogaster (Fruit fly) TR13211_c2_g1_i1 Q8TCQ1 MARH1_HUMAN 6.00E-38 GO:0005794; GO:0042287; GO:0002495; GO:0030659; GO:0031901; GO:0005789; GO:0006955; GO:0016021; GO:0031902; GO:0005765; GO:0005886; GO:0000209; GO:0032588; GO:0004842; GO:0008270 Golgi apparatus; MHC protein binding; antigen processing and presentation of peptide antigen via MHC class II; cytoplasmic vesicle membrane; early endosome membrane; endoplasmic reticulum membrane; immune response; integral to membrane; late endosome membrane; lysosomal membrane; plasma membrane; protein polyubiquitination; trans-Golgi network membrane; ubiquitin-protein ligase activity; zinc ion binding IPR011016; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MARCH1 (EC 6.3.2.-) (Membrane-associated RING finger protein 1) (Membrane-associated RING-CH protein I) (MARCH-I) (RING finger protein 171) MARCH1 RNF171 Homo sapiens (Human) TR13211_c3_g1_i1 Q6ZQ89 MARH6_MOUSE 7.00E-11 GO:0030176; GO:0070936; GO:0004842; GO:0008270 integral to endoplasmic reticulum membrane; protein K48-linked ubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR011016; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MARCH6 (EC 6.3.2.-) (Membrane-associated RING finger protein 6) (Membrane-associated RING-CH protein VI) (MARCH-VI) March6 Kiaa0597 Mus musculus (Mouse) TR13213_c0_g1_i1 O75594 PGRP1_HUMAN 4.00E-22 GO:0008745; GO:0050830; GO:0016045; GO:0005576; GO:0044117; GO:0045087; GO:0032689; GO:0032827; GO:0042834; GO:0009253; GO:0016019; GO:0008270 N-acetylmuramoyl-L-alanine amidase activity; defense response to Gram-positive bacterium; detection of bacterium; extracellular region; growth of symbiont in host; innate immune response; negative regulation of interferon-gamma production; negative regulation of natural killer cell differentiation involved in immune response; peptidoglycan binding; peptidoglycan catabolic process; peptidoglycan receptor activity; zinc ion binding IPR002502; IPR017331; IPR015510; IPR006619; Peptidoglycan recognition protein 1 (Peptidoglycan recognition protein short) (PGRP-S) PGLYRP1 PGLYRP PGRP TNFSF3L SBBI68 UNQ639/PRO1269 Homo sapiens (Human) TR13216_c0_g1_i1 P16157 ANK1_HUMAN 3.00E-11 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR13219_c0_g1_i2 O15442 MPPD1_HUMAN 1.00E-84 GO:0016787 hydrolase activity IPR024201; IPR004843; Metallophosphoesterase domain-containing protein 1 (EC 3.1.-.-) (Adult brain protein 239) (239AB) MPPED1 C22orf1 FAM1A Homo sapiens (Human) TR13221_c0_g1_i1 Q9UPW8 UN13A_HUMAN 2.00E-47 GO:0050435; GO:0030054; GO:0005737; GO:0019992; GO:0060384; GO:0035556; GO:0046872; GO:0031594; GO:0007528; GO:0001956; GO:0042734; GO:0048172; GO:0035249; GO:0016081; GO:0016188; GO:0016082 "beta-amyloid metabolic process; cell junction; cytoplasm; diacylglycerol binding; innervation; intracellular signal transduction; metal ion binding; neuromuscular junction; neuromuscular junction development; positive regulation of neurotransmitter secretion; presynaptic membrane; regulation of short-term neuronal synaptic plasticity; synaptic transmission, glutamatergic; synaptic vesicle docking involved in exocytosis; synaptic vesicle maturation; synaptic vesicle priming" IPR000008; IPR010439; IPR014770; IPR014772; IPR019558; IPR002219; IPR027080; IPR027082; Protein unc-13 homolog A (Munc13-1) UNC13A KIAA1032 Homo sapiens (Human) TR13227_c0_g1_i1 Q10751 ACE_CHICK 5.00E-35 GO:0004180; GO:0016021; GO:0046872; GO:0008237; GO:0008241; GO:0006508 carboxypeptidase activity; integral to membrane; metal ion binding; metallopeptidase activity; peptidyl-dipeptidase activity; proteolysis IPR001548; Angiotensin-converting enzyme (ACE) (EC 3.2.1.-) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (Fragment) ACE DCP1 Gallus gallus (Chicken) TR13229_c0_g2_i1 O88277 FAT2_RAT 4.00E-13 GO:0005509; GO:0005913; GO:0010631; GO:0007156; GO:0016021; GO:0005634; GO:0005886 calcium ion binding; cell-cell adherens junction; epithelial cell migration; homophilic cell adhesion; integral to membrane; nucleus; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR013032; IPR001791; Protocadherin Fat 2 (Multiple epidermal growth factor-like domains protein 1) (Multiple EGF-like domains protein 1) Fat2 Fath2 Megf1 Rattus norvegicus (Rat) TR13229_c2_g1_i1 Q9NYQ8 FAT2_HUMAN 2.00E-11 GO:0005509; GO:0005913; GO:0010631; GO:0007156; GO:0016021; GO:0005634; GO:0005886 calcium ion binding; cell-cell adherens junction; epithelial cell migration; homophilic cell adhesion; integral to membrane; nucleus; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR013032; IPR001791; Protocadherin Fat 2 (hFat2) (Cadherin family member 8) (Multiple epidermal growth factor-like domains protein 1) (Multiple EGF-like domains protein 1) FAT2 CDHF8 KIAA0811 MEGF1 Homo sapiens (Human) TR13254_c0_g1_i1 Q7TPH6 MYCB2_MOUSE 2.00E-06 GO:0030424; GO:0021785; GO:0021952; GO:0015630; GO:0042177; GO:0005634; GO:0051493; GO:0032880; GO:0006355; GO:0006351; GO:0004842; GO:0008270 Q63633 "axon; branchiomotor neuron axon guidance; central nervous system projection neuron axonogenesis; microtubule cytoskeleton; negative regulation of protein catabolic process; nucleus; regulation of cytoskeleton organization; regulation of protein localization; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR004939; IPR017868; IPR008979; IPR027047; IPR013783; IPR014756; IPR012983; IPR009091; IPR000408; IPR003646; IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc) Mycbp2 Pam Phr1 Mus musculus (Mouse) TR13254_c1_g1_i1 Q8K2J9 BTBD6_MOUSE 4.00E-19 GO:0000932 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6 Btbd6 Mus musculus (Mouse) TR13258_c0_g1_i1 C8YR32 LOXH1_MOUSE 2.00E-13 GO:0005262; GO:0050982; GO:0016020; GO:0007605; GO:0032420 calcium channel activity; detection of mechanical stimulus; membrane; sensory perception of sound; stereocilium IPR008976; IPR001024; Lipoxygenase homology domain-containing protein 1 Loxhd1 Mus musculus (Mouse) TR13258_c0_g1_i2 P51399 LOX5_MESAU 8.00E-11 GO:0004051; GO:0005829; GO:0005506; GO:0019370; GO:0005641; GO:0016363; GO:0031965 arachidonate 5-lipoxygenase activity; cytosol; iron ion binding; leukotriene biosynthetic process; nuclear envelope lumen; nuclear matrix; nuclear membrane IPR008976; IPR000907; IPR013819; IPR020834; IPR020833; IPR001885; IPR001024; Lipid metabolism; leukotriene A4 biosynthesis. Arachidonate 5-lipoxygenase (5-LO) (5-lipoxygenase) (EC 1.13.11.34) ALOX5 Mesocricetus auratus (Golden hamster) TR13265_c1_g1_i1 Q01617 CPO_DROME 6.00E-34 GO:0022611; GO:0003729; GO:0007275; GO:0000166; GO:0005634; GO:0042048; GO:0035206; GO:0007268 dormancy process; mRNA binding; multicellular organismal development; nucleotide binding; nucleus; olfactory behavior; regulation of hemocyte proliferation; synaptic transmission IPR012677; IPR000504; Protein couch potato cpo CG43738 Drosophila melanogaster (Fruit fly) TR13269_c0_g1_i1 Q3V129 ULK4_MOUSE 2.00E-42 GO:0005524; GO:0060271; GO:0003351; GO:0004674; GO:0021591 ATP binding; cilium morphogenesis; epithelial cilium movement; protein serine/threonine kinase activity; ventricular system development IPR011989; IPR016024; IPR011009; IPR000719; Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4) Ulk4 Mus musculus (Mouse) TR13271_c0_g1_i1 Q6UXP7 F151B_HUMAN 8.00E-24 IPR019356; Protein FAM151B FAM151B UNQ9217/PRO28685 Homo sapiens (Human) TR13273_c0_g1_i1 O94813 SLIT2_HUMAN 1.00E-41 GO:0005095; GO:0035385; GO:0061364; GO:0048846; GO:0048754; GO:0005509; GO:0002042; GO:0009986; GO:0016337; GO:0071504; GO:0032870; GO:0045499; GO:0021836; GO:0021972; GO:0005737; GO:0033563; GO:0005615; GO:0008201; GO:0001701; GO:0050929; GO:0043237; GO:0060763; GO:0001656; GO:0008045; GO:0030837; GO:0030308; GO:0008285; GO:0090288; GO:0070100; GO:0010596; GO:0010629; GO:0010593; GO:0090027; GO:0071676; GO:0090024; GO:0001933; GO:0090260; GO:0051058; GO:0071672; GO:0043116; GO:0005886; GO:0043065; GO:0050772; GO:0042803; GO:0051414; GO:0031290; GO:0001657 Itself GTPase inhibitor activity; Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; branching morphogenesis of an epithelial tube; calcium ion binding; cell migration involved in sprouting angiogenesis; cell surface; cell-cell adhesion; cellular response to heparin; cellular response to hormone stimulus; chemorepellent activity; chemorepulsion involved in postnatal olfactory bulb interneuron migration; corticospinal neuron axon guidance through spinal cord; cytoplasm; dorsal/ventral axon guidance; extracellular space; heparin binding; in utero embryonic development; induction of negative chemotaxis; laminin-1 binding; mammary duct terminal end bud growth; metanephros development; motor neuron axon guidance; negative regulation of actin filament polymerization; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cellular response to growth factor stimulus; negative regulation of chemokine-mediated signaling pathway; negative regulation of endothelial cell migration; negative regulation of gene expression; negative regulation of lamellipodium assembly; negative regulation of monocyte chemotaxis; negative regulation of mononuclear cell migration; negative regulation of neutrophil chemotaxis; negative regulation of protein phosphorylation; negative regulation of retinal ganglion cell axon guidance; negative regulation of small GTPase mediated signal transduction; negative regulation of smooth muscle cell chemotaxis; negative regulation of vascular permeability; plasma membrane; positive regulation of apoptotic process; positive regulation of axonogenesis; protein homodimerization activity; response to cortisol stimulus; retinal ganglion cell axon guidance; ureteric bud development IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product] SLIT2 SLIL3 Homo sapiens (Human) TR13273_c1_g1_i1 A6H789 LRC3B_BOVIN 2.00E-08 GO:0016021 integral to membrane IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing protein 3B LRRC3B Bos taurus (Bovine) TR13278_c0_g1_i1 Q9QYS1 WNT16_MOUSE 3.00E-51 GO:0016055; GO:0060317; GO:0045165; GO:0005737; GO:0005615; GO:0005109; GO:0030216; GO:0043616; GO:0060548; GO:0030182; GO:0090403; GO:0046330; GO:0010628; GO:0014068; GO:0005578; GO:0090399 Wnt receptor signaling pathway; cardiac epithelial to mesenchymal transition; cell fate commitment; cytoplasm; extracellular space; frizzled binding; keratinocyte differentiation; keratinocyte proliferation; negative regulation of cell death; neuron differentiation; oxidative stress-induced premature senescence; positive regulation of JNK cascade; positive regulation of gene expression; positive regulation of phosphatidylinositol 3-kinase cascade; proteinaceous extracellular matrix; replicative senescence IPR005817; IPR013304; IPR018161; Protein Wnt-16 Wnt16 Mus musculus (Mouse) TR13278_c1_g1_i1 P28105 WNT7A_ALOVU 5.00E-18 GO:0016055; GO:0007275; GO:0005578 Wnt receptor signaling pathway; multicellular organismal development; proteinaceous extracellular matrix IPR005817; IPR013300; Protein Wnt-7a (Fragment) WNT-7A Alopias vulpinus (Thresher shark) (Squalus vulpinus) TR13279_c0_g1_i1 Q8K0U4 HS12A_MOUSE 6.00E-17 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR13279_c2_g1_i1 Q96MM6 HS12B_HUMAN 8.00E-25 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR13284_c0_g1_i1 Q8BX70 VP13C_MOUSE 3.00E-09 IPR015412; IPR026847; IPR026854; IPR009543; Vacuolar protein sorting-associated protein 13C Vps13c Kiaa3021 Mus musculus (Mouse) TR13292_c2_g1_i1 Q9W6F8 WIF1_XENLA 7.00E-10 GO:0016055; GO:0005576; GO:0007275 Wnt receptor signaling pathway; extracellular region; multicellular organismal development IPR000742; IPR013032; IPR003306; IPR013309; Wnt inhibitory factor 1 (WIF-1) wif1 Xenopus laevis (African clawed frog) TR13302_c0_g1_i1 O00602 FCN1_HUMAN 3.00E-38 GO:0003823; GO:0005509; GO:0030246; GO:0005581; GO:0001867; GO:0005576; GO:0008228 Q2TS39 "antigen binding; calcium ion binding; carbohydrate binding; collagen; complement activation, lectin pathway; extracellular region; opsonization" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) FCN1 FCNM Homo sapiens (Human) TR13327_c1_g1_i1 Q9HBR0 S38AA_HUMAN 3.00E-10 GO:0006865; GO:0060348; GO:0016021; GO:0006814 amino acid transport; bone development; integral to membrane; sodium ion transport IPR013057; Putative sodium-coupled neutral amino acid transporter 10 (Solute carrier family 38 member 10) SLC38A10 PP1744 Homo sapiens (Human) TR13336_c0_g1_i1 P0CI65 NPHP3_DANRE 4.00E-22 GO:0016055; GO:0060271; GO:0072372 Wnt receptor signaling pathway; cilium morphogenesis; primary cilium IPR027417; IPR013026; IPR011990; IPR019734; Nephrocystin-3 nphp3 si:dkey-56l10.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR13340_c0_g2_i1 Q9JIQ8 TMPS2_MOUSE 5.00E-06 GO:0005576; GO:0016021; GO:0005886; GO:0006508; GO:0005044; GO:0004252 extracellular region; integral to membrane; plasma membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity IPR023415; IPR002172; IPR001254; IPR018114; IPR001314; IPR001190; IPR017448; IPR009003; Transmembrane protease serine 2 (EC 3.4.21.-) (Epitheliasin) (Plasmic transmembrane protein X) [Cleaved into: Transmembrane protease serine 2 non-catalytic chain; Transmembrane protease serine 2 catalytic chain] Tmprss2 Mus musculus (Mouse) TR13341_c0_g1_i1 Q3MHV9 SERC1_BOVIN 2.00E-19 GO:0005789; GO:0016021; GO:0008654 endoplasmic reticulum membrane; integral to membrane; phospholipid biosynthetic process IPR005016; Serine incorporator 1 (Tumor differentially expressed protein 2) SERINC1 TDE2 Bos taurus (Bovine) TR13344_c0_g1_i1 Q9NUV9 GIMA4_HUMAN 3.00E-08 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR13345_c1_g1_i1 Q14BP6 YV012_MOUSE 3.00E-16 IPR001611; Leucine-rich repeat-containing protein LOC400891 homolog Mus musculus (Mouse) TR13346_c0_g1_i1 Q96XY5 Y2383_SULTO 1.00E-07 IPR002589; Uncharacterized protein STK_23830 STK_23830 Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) TR13349_c2_g1_i1 Q8CJ67 STAU2_MOUSE 9.00E-16 GO:0003725; GO:0005783; GO:0005874; GO:0005730; GO:0006810 double-stranded RNA binding; endoplasmic reticulum; microtubule; nucleolus; transport IPR014720; Double-stranded RNA-binding protein Staufen homolog 2 Stau2 Mus musculus (Mouse) TR13357_c0_g1_i1 Q29041 FCN2_PIG 1.00E-16 GO:0005581; GO:0001867 "collagen; complement activation, lectin pathway" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) FCN2 Sus scrofa (Pig) TR13358_c2_g1_i1 Q14249 NUCG_HUMAN 5.00E-53 GO:0006309; GO:0004519; GO:0001701; GO:0046872; GO:0005739; GO:0003676; GO:0043065; GO:0046677; GO:0034612 apoptotic DNA fragmentation; endonuclease activity; in utero embryonic development; metal ion binding; mitochondrion; nucleic acid binding; positive regulation of apoptotic process; response to antibiotic; response to tumor necrosis factor IPR018524; IPR001604; IPR020821; "Endonuclease G, mitochondrial (Endo G) (EC 3.1.30.-)" ENDOG Homo sapiens (Human) TR13359_c0_g1_i1 O13835 IMP3_SCHPO 8.00E-07 GO:0005730; GO:0019843; GO:0006364; GO:0030532; GO:0005732; GO:0032040; GO:0030515 nucleolus; rRNA binding; rRNA processing; small nuclear ribonucleoprotein complex; small nucleolar ribonucleoprotein complex; small-subunit processome; snoRNA binding IPR022801; IPR001912; IPR002942; U3 small nucleolar ribonucleoprotein protein imp3 (U3 snoRNP protein imp3) imp3 SPAC19D5.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR13359_c0_g1_i2 P29314 RS9_RAT 4.00E-109 GO:0022627; GO:0019843; GO:0003735; GO:0006412 cytosolic small ribosomal subunit; rRNA binding; structural constituent of ribosome; translation IPR022801; IPR005710; IPR001912; IPR018079; IPR002942; 40S ribosomal protein S9 Rps9 Rattus norvegicus (Rat) TR13360_c0_g1_i1 Q00546 TENR_CHICK 2.00E-18 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR013032; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin-R (TN-R) (Restrictin) TNR Gallus gallus (Chicken) TR13361_c0_g1_i1 Q8CI17 MB213_MOUSE 1.00E-11 IPR024810; IPR024802; Protein mab-21-like 3 Mab21L3 Mus musculus (Mouse) TR13361_c0_g2_i1 Q8N8X9 MB213_HUMAN 3.00E-12 IPR024810; IPR024802; Protein mab-21-like 3 MAB21L3 C1orf161 Homo sapiens (Human) TR13362_c0_g1_i1 Q68VK5 TSN5_RAT 3.00E-44 GO:0007155; GO:0008283; GO:0016021 cell adhesion; cell proliferation; integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-5 (Tspan-5) (Transmembrane 4 superfamily member 9) Tspan5 Tm4sf9 Rattus norvegicus (Rat) TR13366_c0_g1_i1 P0DKQ8 ACTP_CONCN 1.00E-10 GO:0019835; GO:0044179; GO:0016021; GO:0006811; GO:0044218 cytolysis; hemolysis in other organism; integral to membrane; ion transport; other organism cell membrane IPR015926; Conoporin-Cn1 Conus consors (Singed cone) TR13371_c0_g1_i1 Q9Z125 CR3L1_MOUSE 6.00E-06 GO:0001077; GO:0003682; GO:0005783; GO:0005789; GO:0016021; GO:0005634; GO:0030500; GO:0006986; GO:0043565 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; chromatin binding; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nucleus; regulation of bone mineralization; response to unfolded protein; sequence-specific DNA binding IPR004827; IPR001630; Cyclic AMP-responsive element-binding protein 3-like protein 1 (cAMP-responsive element-binding protein 3-like protein 1) (Old astrocyte specifically-induced substance) (OASIS) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 1] Creb3l1 Oasis Mus musculus (Mouse) TR13375_c0_g1_i1 Q98930 SORL_CHICK 3.00E-06 GO:0008203; GO:0006897; GO:0016021; GO:0006869; GO:0034362 cholesterol metabolic process; endocytosis; integral to membrane; lipid transport; low-density lipoprotein particle IPR011042; IPR003961; IPR013783; IPR023415; IPR000033; IPR002172; IPR006581; Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (Fragment) SORL1 Gallus gallus (Chicken) TR13383_c0_g1_i1 P08154 EGR1_RAT 3.00E-15 GO:0030509; GO:0001077; GO:0000979; GO:0030217; GO:0071236; GO:0071320; GO:0035690; GO:0071372; GO:0071480; GO:0071363; GO:0071504; GO:0071455; GO:0071456; GO:0032869; GO:0071317; GO:0071260; GO:0071506; GO:0071383; GO:0007623; GO:0005737; GO:0003690; GO:0072110; GO:0070498; GO:0007611; GO:0060291; GO:0046872; GO:0043066; GO:0090090; GO:0000122; GO:0005634; GO:0048709; GO:0072303; GO:0043525; GO:0048169; GO:0033233; GO:0001975; GO:0034465; GO:0042220; GO:0051602; GO:0045471; GO:0009749; GO:0071873; GO:0031667; GO:0035914 BMP signaling pathway; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II core promoter sequence-specific DNA binding; T cell differentiation; cellular response to antibiotic; cellular response to cAMP; cellular response to drug; cellular response to follicle-stimulating hormone stimulus; cellular response to gamma radiation; cellular response to growth factor stimulus; cellular response to heparin; cellular response to hyperoxia; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to isoquinoline alkaloid; cellular response to mechanical stimulus; cellular response to mycophenolic acid; cellular response to steroid hormone stimulus; circadian rhythm; cytoplasm; double-stranded DNA binding; glomerular mesangial cell proliferation; interleukin-1-mediated signaling pathway; learning or memory; long-term synaptic potentiation; metal ion binding; negative regulation of apoptotic process; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; oligodendrocyte differentiation; positive regulation of glomerular metanephric mesangial cell proliferation; positive regulation of neuron apoptotic process; regulation of long-term neuronal synaptic plasticity; regulation of protein sumoylation; response to amphetamine; response to carbon monoxide; response to cocaine; response to electrical stimulus; response to ethanol; response to glucose stimulus; response to norepinephrine stimulus; response to nutrient levels; skeletal muscle cell differentiation IPR021839; IPR021849; IPR007087; IPR015880; IPR013087; Early growth response protein 1 (EGR-1) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor Zif268) (Zinc finger protein Krox-24) Egr1 Rattus norvegicus (Rat) TR13390_c0_g1_i1 P39057 DYHC_ANTCR 4.00E-87 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein beta chain, ciliary" Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR13392_c2_g1_i1 Q99JY3 GIMA4_MOUSE 9.00E-09 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Mus musculus (Mouse) TR13399_c1_g1_i1 P04634 LIPG_RAT 4.00E-50 GO:0007586; GO:0005576; GO:0016298; GO:0016042; GO:0016615; GO:0006108; GO:0005739; GO:0004806 digestion; extracellular region; lipase activity; lipid catabolic process; malate dehydrogenase activity; malate metabolic process; mitochondrion; triglyceride lipase activity IPR000073; IPR006693; IPR025483; Gastric triacylglycerol lipase (GL) (Gastric lipase) (EC 3.1.1.3) (Lingual lipase) Lipf Rattus norvegicus (Rat) TR13403_c1_g1_i1 Q178L7 SDHF2_AEDAE 2.00E-35 GO:0006121; GO:0005739; GO:0018293 "mitochondrial electron transport, succinate to ubiquinone; mitochondrion; protein-FAD linkage" IPR005631; "Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (Succinate dehydrogenase subunit 5, mitochondrial)" AAEL005866 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR13405_c0_g1_i1 Q8BZ25 ANKK1_MOUSE 8.00E-10 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR001245; IPR008271; Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) Ankk1 Mus musculus (Mouse) TR13405_c0_g1_i2 Q3UMR0 ANR27_MOUSE 7.00E-15 GO:0005096; GO:0005769; GO:0045022; GO:0005085; GO:0005764; GO:0043547 Q8QZZ8 GTPase activator activity; early endosome; early endosome to late endosome transport; guanyl-nucleotide exchange factor activity; lysosome; positive regulation of GTPase activity IPR002110; IPR020683; IPR003123; IPR013995; Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein) (VPS9-ankyrin-repeat protein) Ankrd27 Varp Mus musculus (Mouse) TR13405_c2_g1_i1 Q9W0T5 PYX_DROME 2.00E-13 GO:0005262; GO:0034703; GO:0048060; GO:0051290; GO:0009408 calcium channel activity; cation channel complex; negative gravitaxis; protein heterotetramerization; response to heat IPR002110; IPR020683; IPR005821; Transient receptor potential channel pyrexia pyx CG17142 Drosophila melanogaster (Fruit fly) TR13408_c1_g2_i1 Q1ENI8 PXDN_CAEEL 9.00E-45 GO:0005576; GO:0020037; GO:0042744; GO:0046872; GO:0004601 extracellular region; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR000372; Peroxidasin homolog (EC 1.11.1.7) pxn-1 ZK994.3 Caenorhabditis elegans TR13408_c3_g1_i1 P05979 PGH1_SHEEP 3.00E-07 GO:0005737; GO:0051213; GO:0005789; GO:0020037; GO:0016021; GO:0046872; GO:0005634; GO:0004601; GO:0001516; GO:0004666; GO:0008217; GO:0006979 cytoplasm; dioxygenase activity; endoplasmic reticulum membrane; heme binding; integral to membrane; metal ion binding; nucleus; peroxidase activity; prostaglandin biosynthetic process; prostaglandin-endoperoxide synthase activity; regulation of blood pressure; response to oxidative stress IPR000742; IPR010255; IPR002007; IPR019791; Lipid metabolism; prostaglandin biosynthesis. Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1) PTGS1 COX1 Ovis aries (Sheep) TR13414_c0_g1_i1 Q9DBG6 RPN2_MOUSE 2.00E-16 GO:0007568; GO:0000421; GO:0016021; GO:0005634; GO:0008250; GO:0006487; GO:0042493; GO:0043022; GO:0005791; GO:0016757 "aging; autophagic vacuole membrane; integral to membrane; nucleus; oligosaccharyltransferase complex; protein N-linked glycosylation; response to drug; ribosome binding; rough endoplasmic reticulum; transferase activity, transferring glycosyl groups" IPR008814; Protein modification; protein glycosylation. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (EC 2.4.99.18) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (Ribophorin II) (RPN-II) (Ribophorin-2) Rpn2 Mus musculus (Mouse) TR13414_c1_g1_i1 Q9GL01 RPN2_PIG 2.00E-11 GO:0016021; GO:0008250; GO:0006487; GO:0016757 "integral to membrane; oligosaccharyltransferase complex; protein N-linked glycosylation; transferase activity, transferring glycosyl groups" IPR008814; Protein modification; protein glycosylation. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (EC 2.4.99.18) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (Ribophorin II) (RPN-II) (Ribophorin-2) RPN2 Sus scrofa (Pig) TR13415_c0_g1_i1 Q7SXP4 SRS1A_DANRE 4.00E-34 GO:0003723; GO:0008380; GO:0006397; GO:0000166; GO:0005634 RNA binding; RNA splicing; mRNA processing; nucleotide binding; nucleus IPR012677; IPR000504; "Serine/arginine-rich splicing factor 1A (Splicing factor, arginine/serine-rich 1) (Splicing factor, arginine/serine-rich 1A)" srsf1a sfrs1a sfrs1l zgc:66146 Danio rerio (Zebrafish) (Brachydanio rerio) TR13430_c2_g1_i1 Q99081 HTF4_HUMAN 2.00E-09 GO:0070888; GO:0006955; GO:0007517; GO:0005634; GO:0045666; GO:0045893; GO:0006357; GO:0003700; GO:0005667; GO:0006351 "E-box binding; immune response; muscle organ development; nucleus; positive regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent" IPR011598; Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) TCF12 BHLHB20 HEB HTF4 Homo sapiens (Human) TR13439_c0_g1_i2 P04157 PTPRC_RAT 5.00E-07 GO:0030183; GO:0042100; GO:0050853; GO:0030217; GO:0042098; GO:0050852; GO:0000187; GO:0048539; GO:0009986; GO:0051607; GO:0009897; GO:0005925; GO:0002244; GO:0008201; GO:0034113; GO:0002378; GO:0005887; GO:0009898; GO:0007159; GO:0045121; GO:0001915; GO:0006933; GO:0001960; GO:0050732; GO:0031953; GO:0006469; GO:0045060; GO:0030890; GO:0001916; GO:0042102; GO:0046641; GO:0050857; GO:0043065; GO:0045588; GO:2000473; GO:0002925; GO:0048304; GO:2000648; GO:0045059; GO:0019901; GO:0019887; GO:0045577; GO:0050855; GO:0051726; GO:0051209; GO:0010332; GO:0048864; GO:0005001 B cell differentiation; B cell proliferation; B cell receptor signaling pathway; T cell differentiation; T cell proliferation; T cell receptor signaling pathway; activation of MAPK activity; bone marrow development; cell surface; defense response to virus; external side of plasma membrane; focal adhesion; hematopoietic progenitor cell differentiation; heparin binding; heterotypic cell-cell adhesion; immunoglobulin biosynthetic process; integral to plasma membrane; internal side of plasma membrane; leukocyte cell-cell adhesion; membrane raft; negative regulation of T cell mediated cytotoxicity; negative regulation of cell adhesion involved in substrate-bound cell migration; negative regulation of cytokine-mediated signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein autophosphorylation; negative regulation of protein kinase activity; negative thymic T cell selection; positive regulation of B cell proliferation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of alpha-beta T cell proliferation; positive regulation of antigen receptor-mediated signaling pathway; positive regulation of apoptotic process; positive regulation of gamma-delta T cell differentiation; positive regulation of hematopoietic stem cell migration; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of isotype switching to IgG isotypes; positive regulation of stem cell proliferation; positive thymic T cell selection; protein kinase binding; protein kinase regulator activity; regulation of B cell differentiation; regulation of B cell receptor signaling pathway; regulation of cell cycle; release of sequestered calcium ion into cytosol; response to gamma radiation; stem cell development; transmembrane receptor protein tyrosine phosphatase activity IPR003961; IPR013783; IPR016335; IPR024739; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45) Ptprc Rattus norvegicus (Rat) TR1344_c0_g1_i1 Q8C790 F221A_MOUSE 6.00E-60 IPR026755; Protein FAM221A Fam221a Mus musculus (Mouse) TR13472_c0_g2_i1 O75962 TRIO_HUMAN 2.00E-77 GO:0005524; GO:0005089; GO:0097190; GO:0007411; GO:0005829; GO:0005085; GO:0048011; GO:0005543; GO:0043065; GO:0004674; GO:0035023; GO:0051056; GO:0007264; GO:0007185 Q9NRI5 ATP binding; Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; axon guidance; cytosol; guanyl-nucleotide exchange factor activity; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of apoptotic process; protein serine/threonine kinase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine phosphatase signaling pathway IPR001251; IPR000219; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR002290; IPR008271; IPR001452; IPR018159; IPR002017; Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) TRIO Homo sapiens (Human) TR13475_c0_g1_i1 Q9ULJ7 ANR50_HUMAN 3.00E-15 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) TR13482_c0_g1_i1 Q90733 COT2_CHICK 8.00E-24 GO:0009952; GO:0048514; GO:0009566; GO:0030900; GO:0004879; GO:0060173; GO:0001893; GO:0045736; GO:0010596; GO:0001937; GO:0000122; GO:0001764; GO:0005634; GO:0060674; GO:0045893; GO:0009956; GO:0060849; GO:0001972; GO:0043565; GO:0007519; GO:0003707; GO:0060707; GO:0008270 "anterior/posterior pattern specification; blood vessel morphogenesis; fertilization; forebrain development; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; limb development; maternal placenta development; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter; neuron migration; nucleus; placenta blood vessel development; positive regulation of transcription, DNA-dependent; radial pattern formation; regulation of transcription involved in lymphatic endothelial cell fate commitment; retinoic acid binding; sequence-specific DNA binding; skeletal muscle tissue development; steroid hormone receptor activity; trophoblast giant cell differentiation; zinc ion binding" IPR003068; IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; COUP transcription factor 2 (COUP-TF2) (COUP transcription factor II) (COUP-TF II) (Nuclear receptor subfamily 2 group F member 2) NR2F2 TFCOUP2 Gallus gallus (Chicken) TR13486_c1_g1_i1 Q1L673 VDRB_DANRE 4.00E-12 GO:0008434; GO:0005634; GO:0043565; GO:0003707; GO:0070561; GO:0008270 calcitriol receptor activity; nucleus; sequence-specific DNA binding; steroid hormone receptor activity; vitamin D receptor signaling pathway; zinc ion binding IPR008946; IPR000536; IPR001723; IPR000324; IPR001628; IPR013088; "Vitamin D3 receptor B (VDR-B) (1,25-dihydroxyvitamin D3 receptor B) (Nuclear receptor subfamily 1 group I member 1-B)" vdrb nr1i1b gb:dq017633 Danio rerio (Zebrafish) (Brachydanio rerio) TR13486_c1_g2_i1 Q21878 NHR1_CAEEL 3.00E-09 GO:0005634; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Nuclear hormone receptor family member nhr-1 nhr-1 R09G11.2 Caenorhabditis elegans TR13487_c1_g2_i1 Q7RTX9 MOT14_HUMAN 5.00E-10 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR13498_c1_g1_i1 Q27421 OSP_DROME 8.00E-40 GO:0005543 phospholipid binding IPR011993; IPR001849; Protein outspread osp CG3479 Drosophila melanogaster (Fruit fly) TR13502_c0_g1_i1 Q3UVK0 ERMP1_MOUSE 9.00E-44 GO:0005789; GO:0016021; GO:0046872; GO:0008237; GO:0006508 endoplasmic reticulum membrane; integral to membrane; metal ion binding; metallopeptidase activity; proteolysis IPR007484; Endoplasmic reticulum metallopeptidase 1 (EC 3.4.-.-) (Felix-ina) Ermp1 D19Wsu12e Fxna Kiaa1815 Mus musculus (Mouse) TR13509_c0_g1_i1 P27918 PROP_HUMAN 4.00E-08 GO:0006957; GO:0042742; GO:0005615; GO:0030449 "complement activation, alternative pathway; defense response to bacterium; extracellular space; regulation of complement activation" IPR000884; Properdin (Complement factor P) CFP PFC Homo sapiens (Human) TR13509_c0_g1_i2 P35448 TSP1_XENLA 6.00E-20 GO:0005509; GO:0007155; GO:0005576; GO:0008201; GO:0016529 calcium ion binding; cell adhesion; extracellular region; heparin binding; sarcoplasmic reticulum IPR026823; IPR008985; IPR013320; IPR000742; IPR013032; IPR024731; IPR001791; IPR000884; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-1 thbs1 tsp1 Xenopus laevis (African clawed frog) TR13511_c0_g1_i1 Q86BA1 MICAL_DROME 4.00E-08 GO:0071949; GO:0070995; GO:0043914; GO:0003779; GO:0030042; GO:0030047; GO:0007411; GO:0005829; GO:0048813; GO:0016322; GO:0016709; GO:0005886; GO:0045214; GO:0019417; GO:0043195; GO:0008270 "FAD binding; NADPH oxidation; NADPH:sulfur oxidoreductase activity; actin binding; actin filament depolymerization; actin modification; axon guidance; cytosol; dendrite morphogenesis; neuron remodeling; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; plasma membrane; sarcomere organization; sulfur oxidation; terminal bouton; zinc ion binding" IPR001715; IPR022735; IPR001781; Protein-methionine sulfoxide oxidase Mical (EC 1.14.13.-) (Molecule interacting with CasL protein homolog) Mical CG33208 Drosophila melanogaster (Fruit fly) TR13520_c3_g1_i1 F8WLE0 KLP6_RAT 2.00E-63 GO:0005524; GO:0005871; GO:0003777; GO:0031966; GO:0007005; GO:0072384 ATP binding; kinesin complex; microtubule motor activity; mitochondrial membrane; mitochondrion organization; organelle transport along microtubule IPR000253; IPR022140; IPR027640; IPR019821; IPR001752; IPR027417; IPR008984; Kinesin-like protein KLP6 (Kinesin-like protein 6) Klp6 Rattus norvegicus (Rat) TR13533_c0_g1_i1 Q9CQN6 TM14C_MOUSE 2.00E-30 GO:0006783; GO:0016021; GO:0031966; GO:0005739 heme biosynthetic process; integral to membrane; mitochondrial membrane; mitochondrion IPR005349; Transmembrane protein 14C Tmem14c Mus musculus (Mouse) TR13537_c0_g2_i1 Q7T076 LSM11_XENLA 1.00E-23 GO:0003723; GO:0006397; GO:0005634; GO:0030529 RNA binding; mRNA processing; nucleus; ribonucleoprotein complex IPR010920; IPR001163; IPR006649; U7 snRNA-associated Sm-like protein LSm11 lsm11 Xenopus laevis (African clawed frog) TR1354_c0_g1_i1 Q9CPU2 NDUB2_MOUSE 2.00E-13 GO:0005747; GO:0005739; GO:0055114 mitochondrial respiratory chain complex I; mitochondrion; oxidation-reduction process IPR026627; "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (Complex I-AGGG) (CI-AGGG) (NADH-ubiquinone oxidoreductase AGGG subunit)" Ndufb2 Mus musculus (Mouse) TR13547_c0_g1_i1 Q6WCQ1 MPRIP_HUMAN 9.00E-10 GO:0005737; GO:0005856; GO:0005543 Q10728 cytoplasm; cytoskeleton; phospholipid binding IPR011993; IPR001849; Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) MPRIP KIAA0864 MRIP RHOIP3 Homo sapiens (Human) TR13548_c1_g1_i1 Q69Z36 MEX3B_MOUSE 1.00E-16 GO:0003723; GO:0000932; GO:0005634; GO:0008270 RNA binding; cytoplasmic mRNA processing body; nucleus; zinc ion binding IPR004087; IPR004088; IPR001841; IPR013083; RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) Mex3b Kiaa2009 Rkhd3 Mus musculus (Mouse) TR13550_c2_g1_i1 P03977 KV3A4_MOUSE 9.00E-07 GO:0003823 antigen binding IPR007110; IPR013783; IPR013106; IPR003596; Ig kappa chain V-III region 50S10.1 Mus musculus (Mouse) TR13553_c1_g1_i1 Q4ZJM9 C1QL4_MOUSE 1.00E-07 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) TR13554_c1_g1_i1 Q940M4 OCT7_ARATH 1.00E-07 GO:0005524; GO:0090417; GO:0016021; GO:0090416; GO:0005886; GO:0022857 ATP binding; N-methylnicotinate transporter activity; integral to membrane; nicotinate transporter activity; plasma membrane; transmembrane transporter activity IPR020846; IPR016196; IPR005828; IPR005829; Organic cation/carnitine transporter 7 (AtOCT7) OCT7 7-Oct At3g13050 MGH6.16 Arabidopsis thaliana (Mouse-ear cress) TR13556_c0_g1_i1 Q7S8J7 DCL1_NEUCR 6.00E-11 GO:0005524; GO:0003677; GO:0003723; GO:0006396; GO:0051607; GO:0004386; GO:0046872; GO:0050688; GO:0004525 ATP binding; DNA binding; RNA binding; RNA processing; defense response to virus; helicase activity; metal ion binding; regulation of defense response to virus; ribonuclease III activity IPR005034; IPR006935; IPR014001; IPR001650; IPR027417; IPR000999; Dicer-like protein 1 [Includes: Endoribonuclease dcl-1 (EC 3.1.26.-); ATP-dependent helicase dcl-1 (EC 3.6.4.-)] dcl-1 NCU08270 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR13559_c0_g1_i1 Q8IV45 UN5CL_HUMAN 1.00E-23 GO:0005737; GO:0016021; GO:0007165 cytoplasm; integral to membrane; signal transduction IPR011029; IPR000488; IPR000906; UNC5C-like protein (Protein unc-5 homolog C-like) (ZU5 and death domain-containing protein) UNC5CL ZUD Homo sapiens (Human) TR13559_c0_g2_i1 O08747 UNC5C_MOUSE 3.00E-06 GO:0033564; GO:0006915; GO:0007420; GO:0016021; GO:0005042; GO:0005886; GO:0043065; GO:0030334 anterior/posterior axon guidance; apoptotic process; brain development; integral to membrane; netrin receptor activity; plasma membrane; positive regulation of apoptotic process; regulation of cell migration IPR011029; IPR000488; IPR007110; IPR013783; IPR013098; IPR003598; IPR000884; IPR000906; Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C) (Rostral cerebellar malformation protein) Unc5c Rcm Unc5h3 Mus musculus (Mouse) TR13570_c1_g1_i1 Q61066 NR0B1_MOUSE 3.00E-06 GO:0032448; GO:0033327; GO:0003723; GO:0060008; GO:0030325; GO:0004879; GO:0030238; GO:0016020; GO:0045596; GO:0033144; GO:0043433; GO:0000122; GO:0005634; GO:0042788; GO:0008104; GO:0035902; GO:0043565; GO:0007283; GO:0006694; GO:0003707; GO:0003714 Q61539; Q80Z64; P20263; Q6PR54; P70414 DNA hairpin binding; Leydig cell differentiation; RNA binding; Sertoli cell differentiation; adrenal gland development; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; male sex determination; membrane; negative regulation of cell differentiation; negative regulation of intracellular steroid hormone receptor signaling pathway; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; nucleus; polysomal ribosome; protein localization; response to immobilization stress; sequence-specific DNA binding; spermatogenesis; steroid biosynthetic process; steroid hormone receptor activity; transcription corepressor activity IPR008946; IPR000536; IPR025900; IPR001723; Nuclear receptor subfamily 0 group B member 1 (Nuclear receptor DAX-1) Nr0b1 Ahch Dax1 Mus musculus (Mouse) TR13577_c0_g1_i1 Q6UWL6 KIRR2_HUMAN 5.00E-09 GO:0007155; GO:0016337; GO:0016021; GO:0001933; GO:0005886; GO:0036057 cell adhesion; cell-cell adhesion; integral to membrane; negative regulation of protein phosphorylation; plasma membrane; slit diaphragm IPR013162; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Kin of IRRE-like protein 2 (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3) KIRREL2 NEPH3 UNQ5827/PRO19646 Homo sapiens (Human) TR13578_c0_g1_i1 Q9W705 NCOA2_XENLA 2.00E-07 GO:0009790; GO:0016573; GO:0004402; GO:0035556; GO:0005634; GO:0006355; GO:0004871; GO:0046966; GO:0030375; GO:0006351 "embryo development; histone acetylation; histone acetyltransferase activity; intracellular signal transduction; nucleus; regulation of transcription, DNA-dependent; signal transducer activity; thyroid hormone receptor binding; thyroid hormone receptor coactivator activity; transcription, DNA-dependent" IPR011598; IPR010011; IPR009110; IPR014920; IPR017426; IPR000014; IPR013767; IPR014935; IPR008955; Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (xTIF2) ncoa2 tif2 Xenopus laevis (African clawed frog) TR13581_c0_g1_i1 P25723 TLD_DROME 5.00E-08 GO:0007378; GO:0005509; GO:0005576; GO:0008586; GO:0007313; GO:0004222; GO:0010629; GO:0030513; GO:0016485; GO:0006508; GO:0017015; GO:0007362; GO:0008293; GO:0008270 "amnioserosa formation; calcium ion binding; extracellular region; imaginal disc-derived wing vein morphogenesis; maternal specification of dorsal/ventral axis, oocyte, soma encoded; metalloendopeptidase activity; negative regulation of gene expression; positive regulation of BMP signaling pathway; protein processing; proteolysis; regulation of transforming growth factor beta receptor signaling pathway; terminal region determination; torso signaling pathway; zinc ion binding" IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Dorsal-ventral patterning protein tolloid (EC 3.4.24.-) tld CG6868 Drosophila melanogaster (Fruit fly) TR13581_c1_g1_i1 Q7Z407 CSMD3_HUMAN 1.00E-09 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 3 (CUB and sushi multiple domains protein 3) CSMD3 KIAA1894 Homo sapiens (Human) TR13584_c1_g2_i1 Q9NVE5 UBP40_HUMAN 9.00E-12 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.4.19.12) (Deubiquitinating enzyme 40) (Ubiquitin thioesterase 40) (Ubiquitin-specific-processing protease 40) USP40 Homo sapiens (Human) TR13588_c0_g1_i1 Q14134 TRI29_HUMAN 5.00E-06 GO:0005737; GO:1900181; GO:0000122; GO:0003700; GO:0006366; GO:0008270 O15169; O14641; Q96CN9; P49841 cytoplasm; negative regulation of protein localization to nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; zinc ion binding IPR000315; Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein) TRIM29 ATDC Homo sapiens (Human) TR13599_c0_g1_i1 Q60754 MARCO_MOUSE 9.00E-08 GO:0043277; GO:0005581; GO:0045087; GO:0016021; GO:0005886; GO:0005044 apoptotic cell clearance; collagen; innate immune response; integral to membrane; plasma membrane; scavenger receptor activity IPR008160; IPR001190; IPR017448; Macrophage receptor MARCO (Macrophage receptor with collagenous structure) Marco Mus musculus (Mouse) TR13614_c0_g1_i1 Q9D024 CCD47_MOUSE 9.00E-111 GO:0006983; GO:0005509; GO:0055074; GO:0009790; GO:0005783; GO:0016021; GO:0009791 ER overload response; calcium ion binding; calcium ion homeostasis; embryo development; endoplasmic reticulum; integral to membrane; post-embryonic development IPR012879; Coiled-coil domain-containing protein 47 (Adipocyte-specific protein 4) Ccdc47 Asp4 Mus musculus (Mouse) TR13622_c0_g1_i1 P35440 TSP2_CHICK 3.00E-13 GO:0005604; GO:0005509; GO:0007155; GO:0008201; GO:0016525 basement membrane; calcium ion binding; cell adhesion; heparin binding; negative regulation of angiogenesis IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR024731; IPR001791; IPR000884; IPR015455; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-2 THBS2 TSP2 Gallus gallus (Chicken) TR13627_c0_g1_i1 A5GZY1 NEURM_APLCA 8.00E-10 GO:0005576 extracellular region Neuromacin-like protein Aplysia californica (California sea hare) TR13642_c0_g2_i1 O15442 MPPD1_HUMAN 7.00E-28 GO:0016787 hydrolase activity IPR024201; IPR004843; Metallophosphoesterase domain-containing protein 1 (EC 3.1.-.-) (Adult brain protein 239) (239AB) MPPED1 C22orf1 FAM1A Homo sapiens (Human) TR13646_c0_g1_i1 Q24563 DOPR2_DROME 3.00E-25 GO:0008227; GO:0007191; GO:0004935; GO:0071875; GO:0001588; GO:0005887; GO:0030285 "G-protein coupled amine receptor activity; adenylate cyclase-activating dopamine receptor signaling pathway; adrenergic receptor activity; adrenergic receptor signaling pathway; dopamine neurotransmitter receptor activity, coupled via Gs; integral to plasma membrane; integral to synaptic vesicle membrane" IPR002233; IPR000276; IPR017452; Dopamine receptor 2 DopR2 DAMB DopR99B CG18741 Drosophila melanogaster (Fruit fly) TR13646_c0_g2_i1 Q61224 5HT1D_MOUSE 2.00E-24 GO:0007193; GO:0005887; GO:0014827; GO:0050795; GO:0040012; GO:0009636; GO:0051378; GO:0004993; GO:0007268; GO:0042310 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; integral to plasma membrane; intestine smooth muscle contraction; regulation of behavior; regulation of locomotion; response to toxic substance; serotonin binding; serotonin receptor activity; synaptic transmission; vasoconstriction IPR000505; IPR002231; IPR000276; IPR017452; 5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin receptor 1D) Htr1d Gpcr14 Mus musculus (Mouse) TR13646_c1_g1_i1 Q24563 DOPR2_DROME 9.00E-08 GO:0008227; GO:0007191; GO:0004935; GO:0071875; GO:0001588; GO:0005887; GO:0030285 "G-protein coupled amine receptor activity; adenylate cyclase-activating dopamine receptor signaling pathway; adrenergic receptor activity; adrenergic receptor signaling pathway; dopamine neurotransmitter receptor activity, coupled via Gs; integral to plasma membrane; integral to synaptic vesicle membrane" IPR002233; IPR000276; IPR017452; Dopamine receptor 2 DopR2 DAMB DopR99B CG18741 Drosophila melanogaster (Fruit fly) TR13650_c0_g1_i1 Q29041 FCN2_PIG 2.00E-21 GO:0005581; GO:0001867 "collagen; complement activation, lectin pathway" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) FCN2 Sus scrofa (Pig) TR13656_c0_g1_i1 Q9DFQ7 RL24_GILMI 7.00E-61 GO:0005840 ribosome IPR023442; IPR023441; IPR000988; IPR011017; 60S ribosomal protein L24 rpl24 Gillichthys mirabilis (Long-jawed mudsucker) TR13670_c0_g1_i1 Q12955 ANK3_HUMAN 2.00E-06 GO:0043001; GO:0030315; GO:0007411; GO:0043194; GO:0007409; GO:0016323; GO:0045296; GO:0009986; GO:0043034; GO:0014704; GO:0044325; GO:0016328; GO:0005764; GO:0072660; GO:0071709; GO:0000281; GO:0033268; GO:0033270; GO:0010628; GO:1900827; GO:0045838; GO:2000651; GO:0010765; GO:0045211; GO:0030674; GO:0072661; GO:0019228; GO:0043266; GO:0007165; GO:0030507; GO:0014731; GO:0005200; GO:0050808 "Golgi to plasma membrane protein transport; T-tubule; axon guidance; axon initial segment; axonogenesis; basolateral plasma membrane; cadherin binding; cell surface; costamere; intercalated disc; ion channel binding; lateral plasma membrane; lysosome; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; node of Ranvier; paranode region of axon; positive regulation of gene expression; positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; postsynaptic membrane; protein binding, bridging; protein targeting to plasma membrane; regulation of action potential in neuron; regulation of potassium ion transport; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton; synapse organization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) TR13684_c0_g1_i1 Q3T0F5 RAB7A_BOVIN 7.00E-60 GO:0005525; GO:0045022; GO:0005770; GO:0005764; GO:0042470; GO:0045335; GO:0030670; GO:0090383; GO:0090385; GO:0015031; GO:0007264 GTP binding; early endosome to late endosome transport; late endosome; lysosome; melanosome; phagocytic vesicle; phagocytic vesicle membrane; phagosome acidification; phagosome-lysosome fusion; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-7a RAB7A RAB7 Bos taurus (Bovine) TR13684_c2_g1_i1 P36411 RAB7A_DICDI 3.00E-48 GO:0005525; GO:0005764; GO:0045335; GO:0006909; GO:0005886; GO:0015031; GO:0007264 GTP binding; lysosome; phagocytic vesicle; phagocytosis; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-7A rab7A rab7 DDB_G0269236 Dictyostelium discoideum (Slime mold) TR13686_c3_g1_i1 Q7LGC8 CHST3_HUMAN 8.00E-09 GO:0000139; GO:0043029; GO:0005975; GO:0008459; GO:0030206; GO:0016021; GO:0050698 Golgi membrane; T cell homeostasis; carbohydrate metabolic process; chondroitin 6-sulfotransferase activity; chondroitin sulfate biosynthetic process; integral to membrane; proteoglycan sulfotransferase activity IPR016469; IPR027417; IPR000863; Carbohydrate sulfotransferase 3 (EC 2.8.2.17) (Chondroitin 6-O-sulfotransferase 1) (C6ST-1) (Chondroitin 6-sulfotransferase) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0) (GST-0) CHST3 Homo sapiens (Human) TR13688_c0_g1_i1 Q5U239 TM145_XENLA 9.00E-22 GO:0007186; GO:0016021; GO:0019236 G-protein coupled receptor signaling pathway; integral to membrane; response to pheromone IPR019336; Transmembrane protein 145 tmem145 Xenopus laevis (African clawed frog) TR13689_c0_g2_i1 F6ZQ54 TRI13_XENTR 2.00E-12 GO:0005789; GO:0016021; GO:0016874; GO:0016567; GO:0008270 endoplasmic reticulum membrane; integral to membrane; ligase activity; protein ubiquitination; zinc ion binding IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif containing 13 trim13 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR13695_c0_g1_i1 A2RUS2 DEND3_HUMAN 1.00E-06 GO:0017112; GO:0044257; GO:0008333 Rab guanyl-nucleotide exchange factor activity; cellular protein catabolic process; endosome to lysosome transport IPR005112; IPR001194; IPR005113; IPR015943; IPR001680; IPR019775; IPR017986; DENN domain-containing protein 3 DENND3 KIAA0870 Homo sapiens (Human) TR1370_c0_g1_i1 Q5RDQ8 GRM7_PONAB 2.00E-13 GO:0001642; GO:0016021; GO:0005886; GO:0007608 group III metabotropic glutamate receptor activity; integral to membrane; plasma membrane; sensory perception of smell IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR000162; IPR001883; IPR028082; Metabotropic glutamate receptor 7 (mGluR7) GRM7 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR13703_c1_g1_i1 P03360 POL_AVIRE 2.00E-11 GO:0015074; GO:0006310; GO:0003887; GO:0003964; GO:0075713; GO:0003676; GO:0090305; GO:0004523; GO:0046718 DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA-directed DNA polymerase activity; establishment of integrated proviral latency; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis; ribonuclease H activity; viral entry into host cell IPR001584; IPR012337; IPR002156; Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN)] (Fragment) pol Avian reticuloendotheliosis virus TR13707_c2_g1_i1 A0JMA9 KATL2_XENTR 3.00E-47 GO:0005524; GO:0005737; GO:0005874; GO:0051013; GO:0008568 ATP binding; cytoplasm; microtubule; microtubule severing; microtubule-severing ATPase activity IPR003593; IPR003959; IPR027497; IPR006594; IPR013720; IPR027417; Katanin p60 ATPase-containing subunit A-like 2 (Katanin p60 subunit A-like 2) (EC 3.6.4.3) (p60 katanin-like 2) katnal2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR13711_c0_g2_i1 Q91WQ5 TAF5L_MOUSE 6.00E-54 GO:0030914; GO:0043966; GO:0004402; GO:0006355; GO:0003713; GO:0033276; GO:0006351 "STAGA complex; histone H3 acetylation; histone acetyltransferase activity; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription factor TFTC complex; transcription, DNA-dependent" IPR020472; IPR007582; IPR015943; IPR001680; IPR019775; IPR017986; TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65-beta) Taf5l Paf65b Mus musculus (Mouse) TR13717_c0_g1_i1 Q5PR68 CE112_MOUSE 4.00E-30 GO:0005813; GO:0005737 centrosome; cytoplasm IPR027831; Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46) Cep112 Ccdc46 Mus musculus (Mouse) TR13724_c0_g1_i1 Q460N3 PAR15_HUMAN 2.00E-22 GO:0003950; GO:0005634; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) TR13736_c1_g1_i1 Q8C525 M21D2_MOUSE 3.00E-06 IPR024810; IPR024803; Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) TR13737_c1_g1_i1 Q32L40 TCPA_BOVIN 2.00E-42 GO:0005524; GO:0005737; GO:0005815; GO:0006457 ATP binding; cytoplasm; microtubule organizing center; protein folding IPR012715; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) TCP1 CCT1 Bos taurus (Bovine) TR13746_c1_g1_i1 Q5T4S7 UBR4_HUMAN 5.00E-06 GO:0005737; GO:0005856; GO:0016021; GO:0019048; GO:0005634; GO:0042787; GO:0004842; GO:0008270 P03129 cytoplasm; cytoskeleton; integral to membrane; modulation by virus of host morphology or physiology; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR016024; IPR025704; IPR017986; IPR003126; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UBR4 (EC 6.3.2.-) (600 kDa retinoblastoma protein-associated factor) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) (p600) (Zinc finger UBR1-type protein 1) UBR4 KIAA0462 KIAA1307 RBAF600 ZUBR1 Homo sapiens (Human) TR13751_c0_g1_i1 A2VDR2 ACBD6_BOVIN 8.00E-11 GO:0005737; GO:0000062; GO:0008289; GO:0005634 cytoplasm; fatty-acyl-CoA binding; lipid binding; nucleus IPR000582; IPR002110; IPR020683; IPR014352; Acyl-CoA-binding domain-containing protein 6 ACBD6 Bos taurus (Bovine) TR13752_c1_g1_i1 Q9P0K9 FRS1L_HUMAN 1.00E-08 GO:0030054; GO:0016021; GO:0005886; GO:0045202 cell junction; integral to membrane; plasma membrane; synapse IPR005018; DOMON domain-containing protein FRRS1L (Brain protein CG-6) (Ferric-chelate reductase 1-like protein) FRRS1L C9orf4 Homo sapiens (Human) TR13753_c0_g1_i1 Q6F6B3 TANC1_RAT 7.00E-16 GO:0030054; GO:0014069; GO:0045211 Q9UKE5 cell junction; postsynaptic density; postsynaptic membrane IPR002110; IPR020683; IPR027417; IPR013026; IPR011990; IPR013105; IPR019734; "Protein TANC1 (TPR domain, ankyrin-repeat and coiled-coil domain-containing protein 1)" Tanc1 Tanc Rattus norvegicus (Rat) TR13754_c0_g1_i1 P70711 U2D2B_RAT 2.00E-24 GO:0005524; GO:0004842 ATP binding; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 D2B (EC 6.3.2.19) (Ubiquitin carrier protein D2B) (Ubiquitin-conjugating enzyme E2(17)KB 2B) (Ubiquitin-conjugating enzyme E2-17 kDa 2B) (Ubiquitin-protein ligase D2B) Ube2d2b Ube2d2 Rattus norvegicus (Rat) TR13756_c0_g1_i1 Q9NYC9 DYH9_HUMAN 6.00E-54 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0030030; GO:0006928; GO:0035085; GO:0005874; GO:0003777; GO:0007018; GO:0007283 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; cell projection organization; cellular component movement; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement; spermatogenesis IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 9, axonemal (Axonemal beta dynein heavy chain 9) (Ciliary dynein heavy chain 9)" DNAH9 DNAH17L DNAL1 KIAA0357 Homo sapiens (Human) TR13757_c0_g1_i1 Q63347 PRS7_RAT 5.00E-66 GO:0005524; GO:0000932; GO:0017111; GO:0005634; GO:0022624; GO:0030163 ATP binding; cytoplasmic mRNA processing body; nucleoside-triphosphatase activity; nucleus; proteasome accessory complex; protein catabolic process IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) (Protein MSS1) Psmc2 Mss1 Rattus norvegicus (Rat) TR13761_c0_g1_i1 Q8WTN9 CHSTF_OMMSL 9.00E-23 GO:0000139; GO:0050659 Golgi membrane; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IPR027417; IPR000863; Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST) (Fragments) GALNAC4S6ST Ommastrephes sloanei (Arrow squid) (Sloane's squid) TR13761_c0_g2_i1 Q91XQ5 CHSTF_MOUSE 2.00E-41 GO:0050656; GO:0000139; GO:0050659; GO:0019319; GO:0016021 3'-phosphoadenosine 5'-phosphosulfate binding; Golgi membrane; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity; hexose biosynthetic process; integral to membrane IPR027417; IPR000863; Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (B-cell RAG-associated gene protein) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST) Chst15 Brag Galnac4s6st Kiaa0598 Mus musculus (Mouse) TR13764_c1_g1_i1 Q24119 TRH_DROME 9.00E-07 GO:0007443; GO:0048813; GO:0007425; GO:0072175; GO:0046331; GO:0005634; GO:0046982; GO:0007435; GO:0043565; GO:0000981; GO:0004871; GO:0035277 "Malpighian tubule morphogenesis; dendrite morphogenesis; epithelial cell fate determination, open tracheal system; epithelial tube formation; lateral inhibition; nucleus; protein heterodimerization activity; salivary gland morphogenesis; sequence-specific DNA binding; sequence-specific DNA binding RNA polymerase II transcription factor activity; signal transducer activity; spiracle morphogenesis, open tracheal system" IPR011598; IPR001610; IPR000014; IPR013767; IPR013655; Protein trachealess trh CG6883 Drosophila melanogaster (Fruit fly) TR13766_c1_g1_i1 Q49HH9 TS1R3_CANFA 4.00E-08 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR001828; IPR000337; IPR011500; IPR017978; IPR028082; Taste receptor type 1 member 3 (Sweet taste receptor T1R3) TAS1R3 T1R3 Canis familiaris (Dog) (Canis lupus familiaris) TR13766_c1_g1_i2 Q863I4 GRM6_RABIT 2.00E-10 GO:0007216; GO:0004930; GO:0000139; GO:0030425; GO:0050908; GO:0005789; GO:0008066; GO:0005887; GO:0090280 G-protein coupled glutamate receptor signaling pathway; G-protein coupled receptor activity; Golgi membrane; dendrite; detection of light stimulus involved in visual perception; endoplasmic reticulum membrane; glutamate receptor activity; integral to plasma membrane; positive regulation of calcium ion import IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR000162; IPR000112; IPR028082; Metabotropic glutamate receptor 6 (mGluR6) GRM6 Oryctolagus cuniculus (Rabbit) TR13779_c1_g1_i1 Q5FWN8 DNJ6A_XENLA 8.00E-15 GO:0005634; GO:0048471 nucleus; perinuclear region of cytoplasm IPR001623; IPR018253; DnaJ homolog subfamily B member 6-A dnajb6-a Xenopus laevis (African clawed frog) TR13779_c1_g2_i1 A7TGR0 JJJ2_VANPO 2.00E-06 GO:0005737; GO:0005634 cytoplasm; nucleus IPR001623; IPR018253; J protein JJJ2 JJJ2 Kpol_2001p27 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus) TR13794_c1_g1_i1 Q8CG46 SMC5_MOUSE 3.00E-31 GO:0005524; GO:0016605; GO:0030915; GO:0051301; GO:0090398; GO:0000781; GO:0000724; GO:0007067; GO:0034184; GO:0045842; GO:0000722 "ATP binding; PML body; Smc5-Smc6 complex; cell division; cellular senescence; chromosome, telomeric region; double-strand break repair via homologous recombination; mitosis; positive regulation of maintenance of mitotic sister chromatid cohesion; positive regulation of mitotic metaphase/anaphase transition; telomere maintenance via recombination" IPR027417; IPR003395; IPR027131; Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (mSMC5) (Protein expressed in male leptotene and zygotene spermatocytes 453) (MLZ-453) Smc5 Kiaa0594 Smc5l1 Mus musculus (Mouse) TR13796_c0_g1_i1 O14578 CTRO_HUMAN 2.00E-18 GO:0005524; GO:0015629; GO:0000910; GO:0016358; GO:0048699; GO:0035556; GO:0046872; GO:0007091; GO:0007067; GO:0000070; GO:0050774; GO:0005543; GO:0004674; GO:0001726; GO:0005083; GO:0007283; GO:0005773 ATP binding; actin cytoskeleton; cytokinesis; dendrite development; generation of neurons; intracellular signal transduction; metal ion binding; metaphase/anaphase transition of mitotic cell cycle; mitosis; mitotic sister chromatid segregation; negative regulation of dendrite morphogenesis; phospholipid binding; protein serine/threonine kinase activity; ruffle; small GTPase regulator activity; spermatogenesis; vacuole IPR000961; IPR001180; IPR017405; IPR011009; IPR011993; IPR017892; IPR001849; IPR002219; IPR000719; IPR017441; IPR020684; IPR002290; IPR008271; Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) CIT CRIK KIAA0949 STK21 Homo sapiens (Human) TR13798_c0_g1_i1 Q9VE04 RM55_DROME 1.00E-16 GO:0005762; GO:0007275; GO:0003735; GO:0006412 mitochondrial large ribosomal subunit; multicellular organismal development; structural constituent of ribosome; translation IPR018615; "39S ribosomal protein L55, mitochondrial (L55mt) (MRP-L55)" mRpL55 CG14283 Drosophila melanogaster (Fruit fly) TR13801_c0_g1_i1 Q9UM22 EPDR1_HUMAN 6.00E-09 GO:0005509; GO:0007160; GO:0005576; GO:0005764 calcium ion binding; cell-matrix adhesion; extracellular region; lysosome IPR001299; IPR018224; Mammalian ependymin-related protein 1 (MERP-1) (Upregulated in colorectal cancer gene 1 protein) EPDR1 MERP1 UCC1 Homo sapiens (Human) TR13807_c0_g1_i1 Q9CPW5 SSRB_MOUSE 4.00E-76 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR008856; Translocon-associated protein subunit beta (TRAP-beta) (Signal sequence receptor subunit beta) (SSR-beta) Ssr2 Mus musculus (Mouse) TR13810_c0_g1_i1 A6NED2 RCCD1_HUMAN 2.00E-28 GO:0005737; GO:0005886 cytoplasm; plasma membrane IPR009091; IPR000408; RCC1 domain-containing protein 1 RCCD1 Homo sapiens (Human) TR13814_c3_g1_i1 Q7Z5J8 ANKAR_HUMAN 5.00E-17 GO:0016021 integral to membrane IPR002110; IPR020683; IPR011989; IPR016024; IPR000225; Ankyrin and armadillo repeat-containing protein ANKAR Homo sapiens (Human) TR13816_c0_g1_i1 Q9WVH6 ANGP4_MOUSE 6.00E-07 GO:0048014; GO:0001525; GO:0071456; GO:0007492; GO:0005615; GO:0016525; GO:0043066; GO:0043537; GO:0045766; GO:0043536; GO:0030297; GO:0005172 Tie signaling pathway; angiogenesis; cellular response to hypoxia; endoderm development; extracellular space; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of blood vessel endothelial cell migration; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; transmembrane receptor protein tyrosine kinase activator activity; vascular endothelial growth factor receptor binding IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3) Angpt4 Agpt4 Ang3 Mus musculus (Mouse) TR13817_c0_g1_i1 Q9ULJ7 ANR50_HUMAN 6.00E-10 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) TR1382_c1_g1_i1 Q4R3Y4 S27A4_MACFA 1.00E-16 GO:0006631; GO:0016021; GO:0016874; GO:0006869; GO:0000166 fatty acid metabolic process; integral to membrane; ligase activity; lipid transport; nucleotide binding IPR025110; IPR020845; IPR000873; IPR022272; Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (EC 6.2.1.-) (Solute carrier family 27 member 4) SLC27A4 FATP4 QtsA-13277 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR13827_c0_g1_i1 P27085 RS26_OCTVU 6.00E-45 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000892; 40S ribosomal protein S26 RPS26 Octopus vulgaris (Common octopus) TR13830_c0_g1_i1 Q96MM6 HS12B_HUMAN 2.00E-15 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR13831_c1_g1_i1 P01130 LDLR_HUMAN 6.00E-22 GO:0005794; GO:0005509; GO:0042632; GO:0070508; GO:0008203; GO:0030669; GO:0005905; GO:0005769; GO:0010008; GO:0009897; GO:0005887; GO:0030299; GO:0005770; GO:0042159; GO:0042157; GO:0034362; GO:0030169; GO:0034383; GO:0005041; GO:0005764; GO:0019048; GO:0015914; GO:0007603; GO:0010867; GO:0010899; GO:0001523; GO:0044281; GO:0030229 Q8NBP7 "Golgi apparatus; calcium ion binding; cholesterol homeostasis; cholesterol import; cholesterol metabolic process; clathrin-coated endocytic vesicle membrane; coated pit; early endosome; endosome membrane; external side of plasma membrane; integral to plasma membrane; intestinal cholesterol absorption; late endosome; lipoprotein catabolic process; lipoprotein metabolic process; low-density lipoprotein particle; low-density lipoprotein particle binding; low-density lipoprotein particle clearance; low-density lipoprotein receptor activity; lysosome; modulation by virus of host morphology or physiology; phospholipid transport; phototransduction, visible light; positive regulation of triglyceride biosynthetic process; regulation of phosphatidylcholine catabolic process; retinoid metabolic process; small molecule metabolic process; very-low-density lipoprotein particle receptor activity" IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor (LDL receptor) LDLR Homo sapiens (Human) TR13833_c0_g1_i1 Q96N64 PWP2A_HUMAN 2.00E-36 Q13547 IPR000313; PWWP domain-containing protein 2A PWWP2A KIAA1935 MST101 Homo sapiens (Human) TR13836_c1_g1_i1 Q0MQJ3 NDUBB_PONPY 2.00E-07 GO:0016021; GO:0005743; GO:0055114; GO:0070469 integral to membrane; mitochondrial inner membrane; oxidation-reduction process; respiratory chain IPR019329; "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (Complex I-ESSS) (CI-ESSS) (NADH-ubiquinone oxidoreductase ESSS subunit)" NDUFB11 Pongo pygmaeus (Bornean orangutan) TR13839_c0_g1_i1 Q4J781 ADH_SULAC 2.00E-11 GO:0004022; GO:0008270 alcohol dehydrogenase (NAD) activity; zinc ion binding IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; NAD-dependent alcohol dehydrogenase (EC 1.1.1.1) adh Saci_2057 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) TR13839_c0_g1_i2 O97764 QOR_BOVIN 2.00E-08 GO:0003677; GO:0050661; GO:0070402; GO:0003960; GO:0005829; GO:0003730; GO:0051289; GO:0042178; GO:0008270 DNA binding; NADP binding; NADPH binding; NADPH:quinone reductase activity; cytosol; mRNA 3'-UTR binding; protein homotetramerization; xenobiotic catabolic process; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; IPR002364; Zeta-crystallin CRYZ Bos taurus (Bovine) TR13842_c1_g1_i1 Q2LK54 COL12_CHICK 2.00E-10 GO:0030246; GO:0005581; GO:0016021; GO:0046872 carbohydrate binding; collagen; integral to membrane; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-12 (Collectin-3) (CL-3) (cCL-3) COLEC12 CL3 Gallus gallus (Chicken) TR13845_c0_g2_i1 Q3U3V8 XRRA1_MOUSE 1.00E-24 GO:0005737; GO:0005634; GO:0010165 cytoplasm; nucleus; response to X-ray IPR001611; X-ray radiation resistance-associated protein 1 Xrra1 Mus musculus (Mouse) TR13848_c1_g1_i1 O60663 LMX1B_HUMAN 3.00E-30 GO:0008219; GO:0008283; GO:0021954; GO:0021587; GO:0030199; GO:0071542; GO:0009953; GO:0001701; GO:0035108; GO:0030901; GO:0030182; GO:0001764; GO:0005634; GO:0035265; GO:0045944; GO:0043565; GO:0003700; GO:0002930; GO:0006351; GO:0008270 "cell death; cell proliferation; central nervous system neuron development; cerebellum morphogenesis; collagen fibril organization; dopaminergic neuron differentiation; dorsal/ventral pattern formation; in utero embryonic development; limb morphogenesis; midbrain development; neuron differentiation; neuron migration; nucleus; organ growth; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; trabecular meshwork development; transcription, DNA-dependent; zinc ion binding" IPR017970; IPR001356; IPR009057; IPR001781; LIM homeobox transcription factor 1-beta (LIM/homeobox protein 1.2) (LMX-1.2) (LIM/homeobox protein LMX1B) LMX1B Homo sapiens (Human) TR13848_c3_g1_i1 P53410 ISL2_CHICK 2.00E-16 GO:0007275; GO:0005634; GO:0043565; GO:0003700; GO:0008270 multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; zinc ion binding IPR017970; IPR001356; IPR009057; IPR001781; Insulin gene enhancer protein ISL-2 (Islet-2) (Fragment) ISL2 ISL-2 Gallus gallus (Chicken) TR13858_c0_g1_i1 Q54F46 WARA_DICDI 6.00E-28 GO:0009653; GO:0007275; GO:0005634; GO:0045595; GO:0043565; GO:0003700; GO:0006351 "anatomical structure morphogenesis; multicellular organismal development; nucleus; regulation of cell differentiation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR002110; IPR020683; IPR017970; IPR001356; IPR009057; Homeobox protein Wariai (Homeobox protein 1) (DdHbx-1) warA hbx1 wri DDB_G0291075 Dictyostelium discoideum (Slime mold) TR13869_c1_g1_i1 Q6YHK3 CD109_HUMAN 3.00E-07 GO:0031225; GO:0005615; GO:0010951; GO:0005886; GO:0004867 anchored to membrane; extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) TR13872_c0_g1_i1 P32037 GTR3_MOUSE 2.00E-22 GO:0055056; GO:0002080; GO:0033300; GO:0016021; GO:0005886 D-glucose transmembrane transporter activity; acrosomal membrane; dehydroascorbic acid transporter activity; integral to membrane; plasma membrane IPR002945; IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3)" Slc2a3 Glut-3 Glut3 Mus musculus (Mouse) TR13872_c0_g2_i1 P43427 GTR5_RAT 6.00E-20 GO:0016324; GO:0071332; GO:0005353; GO:0005355; GO:0016021 apical plasma membrane; cellular response to fructose stimulus; fructose transmembrane transporter activity; glucose transmembrane transporter activity; integral to membrane IPR002442; IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5)" Slc2a5 Glut5 Rattus norvegicus (Rat) TR13878_c1_g1_i1 Q5ZIJ9 MIB2_CHICK 1.00E-30 GO:0007219; GO:0005737; GO:0004842; GO:0008270 Notch signaling pathway; cytoplasm; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) TR13881_c1_g1_i1 O60500 NPHN_HUMAN 2.00E-09 GO:0007254; GO:0007155; GO:0042995; GO:0007588; GO:0032836; GO:0072015; GO:0005887; GO:0007520; GO:0030838; GO:0044062; GO:0007519; GO:0036057 P46940; P16333 JNK cascade; cell adhesion; cell projection; excretion; glomerular basement membrane development; glomerular visceral epithelial cell development; integral to plasma membrane; myoblast fusion; positive regulation of actin filament polymerization; regulation of excretion; skeletal muscle tissue development; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) NPHS1 NPHN Homo sapiens (Human) TR13887_c0_g1_i1 O75467 Z324A_HUMAN 1.00E-12 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 324A (Zinc finger protein ZF5128) ZNF324 ZNF324A Homo sapiens (Human) TR13889_c0_g1_i1 P30437 CP17A_ONCMY 1.00E-41 GO:0047442; GO:0020037; GO:0005506; GO:0016020; GO:0004508; GO:0006694 17-alpha-hydroxyprogesterone aldolase activity; heme binding; iron ion binding; membrane; steroid 17-alpha-monooxygenase activity; steroid biosynthetic process IPR001128; IPR017972; IPR002401; Lipid metabolism; steroid biosynthesis. "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.99.9) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" cyp17a1 cyp17 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR13892_c0_g1_i1 P02269 H2A_ASTRU 3.00E-47 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR002119; Histone H2A Asterias rubens (Common European starfish) (Asterias vulgaris) TR13900_c0_g2_i1 Q7Z442 PK1L2_HUMAN 7.00E-27 GO:0005509; GO:0030246; GO:0016021; GO:0006811; GO:0007218 calcium ion binding; carbohydrate binding; integral to membrane; ion transport; neuropeptide signaling pathway IPR001304; IPR016186; IPR016187; IPR000203; IPR000922; IPR008976; IPR002859; IPR013122; IPR003915; IPR001024; IPR014010; Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) PKD1L2 KIAA1879 PC1L2 Homo sapiens (Human) TR13907_c0_g1_i1 Q5ZHY5 CHIP_CHICK 3.00E-51 GO:0006281; GO:0071218; GO:0005737; GO:0006515; GO:0042405; GO:0090035; GO:0032436; GO:0031398; GO:0043161; GO:0070534; GO:0051865; GO:0042803; GO:0000209; GO:0031943; GO:0000151; GO:0030579; GO:0034450 DNA repair; cellular response to misfolded protein; cytoplasm; misfolded or incompletely synthesized protein catabolic process; nuclear inclusion body; positive regulation of chaperone-mediated protein complex assembly; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; proteasomal ubiquitin-dependent protein catabolic process; protein K63-linked ubiquitination; protein autoubiquitination; protein homodimerization activity; protein polyubiquitination; regulation of glucocorticoid metabolic process; ubiquitin ligase complex; ubiquitin-dependent SMAD protein catabolic process; ubiquitin-ubiquitin ligase activity IPR013026; IPR011990; IPR013105; IPR019734; IPR003613; IPR013083; STIP1 homology and U box-containing protein 1 (EC 6.3.2.-) STUB1 RCJMB04_32b21 Gallus gallus (Chicken) TR13907_c1_g1_i1 Q9SRS9 CHIP_ARATH 2.00E-23 GO:0009737; GO:0009651; GO:0009266; GO:0000151; GO:0004842 response to abscisic acid stimulus; response to salt stress; response to temperature stimulus; ubiquitin ligase complex; ubiquitin-protein ligase activity IPR013026; IPR011990; IPR013105; IPR019734; IPR003613; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase CHIP (EC 6.3.2.-) (Carboxyl terminus of HSC70-interacting protein) (AtCHIP) (Plant U-box protein 61) (U-box domain-containing protein 61) CHIP PUB61 At3g07370 F21O3.8 Arabidopsis thaliana (Mouse-ear cress) TR13914_c0_g1_i1 Q9UIF3 TEKT2_HUMAN 4.00E-24 GO:0030030; GO:0001539; GO:0035085; GO:0005874; GO:0000226; GO:0030317 cell projection organization; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule cytoskeleton organization; sperm motility IPR000435; Tektin-2 (Tektin-t) (Testicular tektin) (Testicular tektin B1-like protein) (TEKTB1) (Tektin-B1) TEKT2 Homo sapiens (Human) TR13917_c0_g1_i1 Q4JIJ3 METH_BOVIN 1.00E-42 GO:0031419; GO:0005737; GO:0008898; GO:0008705; GO:0042558; GO:0008270 cobalamin binding; cytoplasm; homocysteine S-methyltransferase activity; methionine synthase activity; pteridine-containing compound metabolic process; zinc ion binding IPR003759; IPR006158; IPR011005; IPR011822; IPR000489; IPR003726; IPR004223; Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1. Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Vitamin-B12 dependent methionine synthase) (MS) MTR Bos taurus (Bovine) TR13920_c0_g1_i1 Q2T9K6 FEM1C_XENLA 2.00E-07 GO:0005737; GO:0016567 cytoplasm; protein ubiquitination IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog C (FEM1c) (FEM1-gamma) fem1c Xenopus laevis (African clawed frog) TR13920_c0_g1_i2 Q96JP0 FEM1C_HUMAN 2.00E-07 GO:0005737; GO:0016567 cytoplasm; protein ubiquitination IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog C (FEM1c) (FEM1-gamma) FEM1C KIAA1785 Homo sapiens (Human) TR13927_c0_g1_i1 Q8K448 ABCA5_MOUSE 5.00E-16 GO:0005524; GO:0006200; GO:0016887; GO:0000139; GO:0033344; GO:0034375; GO:0016021; GO:0005770; GO:0031902; GO:0005765; GO:0005764; GO:0010745; GO:0043691 ATP binding; ATP catabolic process; ATPase activity; Golgi membrane; cholesterol efflux; high-density lipoprotein particle remodeling; integral to membrane; late endosome; late endosome membrane; lysosomal membrane; lysosome; negative regulation of macrophage derived foam cell differentiation; reverse cholesterol transport IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 5 Abca5 Kiaa1888 Mus musculus (Mouse) TR13929_c1_g1_i1 Q8NEE6 FXL13_HUMAN 1.00E-44 IPR001810; IPR006553; F-box/LRR-repeat protein 13 (F-box and leucine-rich repeat protein 13) FBXL13 FBL13 Homo sapiens (Human) TR13935_c0_g1_i1 Q3UQ28 PXDN_MOUSE 3.00E-07 GO:0005783; GO:0031012; GO:0030198; GO:0005201; GO:0005615; GO:0020037; GO:0042744; GO:0046872; GO:0004601; GO:0005578 endoplasmic reticulum; extracellular matrix; extracellular matrix organization; extracellular matrix structural constituent; extracellular space; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity; proteinaceous extracellular matrix IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; IPR001007; Peroxidasin homolog (EC 1.11.1.7) Pxdn Kiaa0230 Mus musculus (Mouse) TR13938_c1_g1_i1 Q8K083 ZN536_MOUSE 4.00E-06 GO:0046872; GO:0045665; GO:0048387; GO:0005634; GO:0006355; GO:0044323; GO:0006351 "metal ion binding; negative regulation of neuron differentiation; negative regulation of retinoic acid receptor signaling pathway; nucleus; regulation of transcription, DNA-dependent; retinoic acid-responsive element binding; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 536 Znf536 Kiaa0390 Zfp536 Mus musculus (Mouse) TR13939_c1_g1_i1 P25059 POL_BLVAU 5.00E-06 GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0075713; GO:0090305; GO:0004523; GO:0046718 DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; establishment of integrated proviral latency; nucleic acid phosphodiester bond hydrolysis; ribonuclease H activity; viral entry into host cell IPR001037; IPR001584; IPR012337; IPR002156; IPR000477; Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN)] pol Bovine leukemia virus (isolate Australian) (BLV) TR13939_c1_g2_i2 P10394 POL4_DROME 1.00E-16 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR13941_c0_g1_i1 P40480 HOS4_YEAST 2.00E-09 GO:0034967; GO:0016575; GO:0045835 P38262 Set3 complex; histone deacetylation; negative regulation of meiosis IPR002110; IPR020683; Protein HOS4 HOS4 YIL112W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR13941_c0_g2_i1 Q80YE7 DAPK1_MOUSE 1.00E-12 GO:0005524; GO:0015629; GO:0005516; GO:0004683; GO:0071346; GO:0005829; GO:0008625; GO:0007243; GO:0043066; GO:1902042; GO:0017148; GO:0046777; GO:0004672; GO:2000310 Q01097 ATP binding; actin cytoskeleton; calmodulin binding; calmodulin-dependent protein kinase activity; cellular response to interferon-gamma; cytosol; extrinsic apoptotic signaling pathway via death domain receptors; intracellular protein kinase cascade; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of translation; protein autophosphorylation; protein kinase activity; regulation of N-methyl-D-aspartate selective glutamate receptor activity IPR002110; IPR020683; IPR011029; IPR000488; IPR011009; IPR020675; IPR027417; IPR000719; IPR017441; IPR002290; IPR008271; Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) Dapk1 Mus musculus (Mouse) TR13944_c1_g1_i1 P26928 HGFL_MOUSE 1.00E-05 GO:0007566; GO:0005576; GO:0006508; GO:0004252 embryo implantation; extracellular region; proteolysis; serine-type endopeptidase activity IPR024174; IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR001254; IPR001314; IPR009003; Hepatocyte growth factor-like protein (Macrophage stimulatory protein) (MSP) [Cleaved into: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain] Mst1 Hgfl Mus musculus (Mouse) TR13959_c0_g1_i1 Q9P275 UBP36_HUMAN 1.00E-22 GO:0008234; GO:0005730; GO:0004221; GO:0006511 cysteine-type peptidase activity; nucleolus; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) USP36 KIAA1453 Homo sapiens (Human) TR13966_c2_g1_i1 Q6DIV6 VIAAT_XENTR 5.00E-25 GO:0030659; GO:0016021; GO:0006836 cytoplasmic vesicle membrane; integral to membrane; neurotransmitter transport IPR013057; Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) slc32a1 viaat Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR13969_c0_g1_i1 Q0IUU4 CML2_ORYSJ 1.00E-15 GO:0005509; GO:0016020 calcium ion binding; membrane IPR011992; IPR018247; IPR002048; Putative calmodulin-like protein 2 CML2 Os11g0134400 LOC_Os11g03980 OsJ_031538 Oryza sativa subsp. japonica (Rice) TR13981_c0_g1_i1 P0CW18 PRS56_HUMAN 1.00E-19 GO:0043010; GO:0005783; GO:0006508; GO:0004252 camera-type eye development; endoplasmic reticulum; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Serine protease 56 (EC 3.4.21.-) PRSS56 Homo sapiens (Human) TR13981_c1_g1_i1 Q29461 CEL2A_BOVIN 2.00E-07 GO:0005576; GO:0006508; GO:0004252 extracellular region; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Chymotrypsin-like elastase family member 2A (EC 3.4.21.71) (Elastase II) (Elastase-2) (Elastase-2A) CELA2A ELA2 ELA2A Bos taurus (Bovine) TR13983_c1_g1_i1 Q9P2D0 IBTK_HUMAN 4.00E-20 GO:0005737; GO:0016020; GO:0005634; GO:0019901; GO:0030292; GO:0051209 cytoplasm; membrane; nucleus; protein kinase binding; protein tyrosine kinase inhibitor activity; release of sequestered calcium ion into cytosol IPR002110; IPR020683; IPR000210; IPR011333; IPR013069; IPR009091; IPR000408; Inhibitor of Bruton tyrosine kinase (IBtk) IBTK BTKI KIAA1417 Homo sapiens (Human) TR13987_c1_g1_i1 P85831 PROH4_APIME 3.00E-12 GO:0005576 extracellular region IPR023415; IPR002172; Prohormone-4 [Cleaved into: Brain peptide IDLSRFYGHFNT; Brain peptide IDLSRFYGHFN; Brain peptide IDLSRFYGHF; Brain peptide DLSRFYGHFNT; Brain peptide DLSRFYGHFN; Brain peptide DLSRFYGHF] Apis mellifera (Honeybee) TR13991_c2_g1_i1 P17136 RSMB_RAT 5.00E-35 GO:0003723; GO:0008380; GO:0005683; GO:0006397; GO:0005681 RNA binding; RNA splicing; U7 snRNP; mRNA processing; spliceosomal complex IPR010920; IPR001163; IPR006649; IPR017131; Small nuclear ribonucleoprotein-associated protein B (snRNP-B) (snRPB) (SM11) (Sm protein B) (Sm-B) (SmB) (Fragment) Snrpb Rattus norvegicus (Rat) TR1401_c0_g1_i1 Q6YBV0 S36A4_HUMAN 6.00E-07 GO:0015808; GO:0016021; GO:0015824; GO:0015293; GO:0015827 L-alanine transport; integral to membrane; proline transport; symporter activity; tryptophan transport IPR013057; Proton-coupled amino acid transporter 4 (Proton/amino acid transporter 4) (Solute carrier family 36 member 4) SLC36A4 PAT4 Homo sapiens (Human) TR14013_c1_g1_i1 Q8HZM5 GLNA_CANFA 6.00E-47 GO:0005524; GO:0004351; GO:0004356; GO:0006542; GO:0005739 ATP binding; glutamate decarboxylase activity; glutamate-ammonia ligase activity; glutamine biosynthetic process; mitochondrion IPR008147; IPR014746; IPR008146; IPR027303; IPR027302; Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate decarboxylase) (EC 4.1.1.15) (Glutamate--ammonia ligase) GLUL Canis familiaris (Dog) (Canis lupus familiaris) TR14024_c1_g1_i1 P86854 PLCL_MYTGA 1.00E-10 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR14024_c1_g2_i1 Q5IS41 NCAN_PANTR 1.00E-08 GO:0005509; GO:0030246; GO:0007155; GO:0005576; GO:0005540 calcium ion binding; carbohydrate binding; cell adhesion; extracellular region; hyaluronic acid binding IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Neurocan core protein (Chondroitin sulfate proteoglycan 3) NCAN CSPG3 Pan troglodytes (Chimpanzee) TR14025_c0_g1_i1 Q9NP73 ALG13_HUMAN 9.00E-19 GO:0004577; GO:0030246; GO:0008234; GO:0006488; GO:0005789; GO:0030259; GO:0043687; GO:0018279; GO:0006508 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity; carbohydrate binding; cysteine-type peptidase activity; dolichol-linked oligosaccharide biosynthetic process; endoplasmic reticulum membrane; lipid glycosylation; post-translational protein modification; protein N-linked glycosylation via asparagine; proteolysis IPR007235; IPR003323; IPR002999; Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (EC 2.4.1.141) (EC 3.4.19.12) (Asparagine-linked glycosylation 13 homolog) (Glycosyltransferase 28 domain-containing protein 1) (UDP-N-acetylglucosamine transferase subunit ALG13 homolog) ALG13 CXorf45 GLT28D1 MDS031 Homo sapiens (Human) TR14025_c0_g1_i2 P10383 OTU_DROME 4.00E-07 GO:0051276; GO:0005737; GO:0019099; GO:0048134; GO:0048477; GO:0032877 chromosome organization; cytoplasm; female germ-line sex determination; germ-line cyst formation; oogenesis; positive regulation of DNA endoreduplication IPR003323; IPR002999; Protein ovarian tumor locus otu CG12743 Drosophila melanogaster (Fruit fly) TR14037_c0_g1_i1 Q499N5 ACSF2_RAT 2.00E-54 GO:0005524; GO:0006631; GO:0016874; GO:0005739 ATP binding; fatty acid metabolic process; ligase activity; mitochondrion IPR025110; IPR020845; IPR000873; "Acyl-CoA synthetase family member 2, mitochondrial (EC 6.2.1.-)" Acsf2 Rattus norvegicus (Rat) TR14039_c1_g1_i1 Q96QE3 ATAD5_HUMAN 9.00E-11 GO:0005524; GO:0017111; GO:0005634; GO:0006974 ATP binding; nucleoside-triphosphatase activity; nucleus; response to DNA damage stimulus IPR003593; IPR003959; IPR027417; ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) ATAD5 C17orf41 FRAG1 Homo sapiens (Human) TR14041_c1_g1_i1 A2AM05 CNTLN_MOUSE 3.00E-14 GO:0005814 centriole Centlein (Centrosomal protein) Cntln Mus musculus (Mouse) TR14048_c0_g1_i1 Q8CFE4 SCYL2_MOUSE 2.00E-31 GO:0005524; GO:0005794; GO:0030136; GO:0010008; GO:0008333; GO:0090090; GO:0048471; GO:2000370; GO:0002092; GO:0004672; GO:2000286 ATP binding; Golgi apparatus; clathrin-coated vesicle; endosome membrane; endosome to lysosome transport; negative regulation of canonical Wnt receptor signaling pathway; perinuclear region of cytoplasm; positive regulation of clathrin-mediated endocytosis; positive regulation of receptor internalization; protein kinase activity; receptor internalization involved in canonical Wnt receptor signaling pathway IPR011989; IPR016024; IPR011009; IPR000719; SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa) Scyl2 Cvak104 D10Ertd802e Mus musculus (Mouse) TR14050_c0_g1_i1 Q9UPZ3 HPS5_HUMAN 3.00E-22 GO:0007596; GO:0005829; GO:0006996; GO:0043473 blood coagulation; cytosol; organelle organization; pigmentation IPR017217; IPR015943; IPR017986; Hermansky-Pudlak syndrome 5 protein (Alpha-integrin-binding protein 63) (Ruby-eye protein 2 homolog) (Ru2) HPS5 AIBP63 KIAA1017 Homo sapiens (Human) TR14052_c0_g1_i1 Q641F3 COLA1_XENLA 1.00E-08 GO:0005581; GO:0005737 collagen; cytoplasm IPR008160; IPR008985; IPR013320; IPR001791; IPR002035; Collagen alpha-1(XXI) chain col21a1 Xenopus laevis (African clawed frog) TR14072_c1_g1_i1 Q96266 GSTF8_ARATH 1.00E-07 GO:0009941; GO:0009570; GO:0005829; GO:0042742; GO:0043295; GO:0004364; GO:0005634; GO:0004601; GO:0009409; GO:0080167; GO:0009651; GO:0009636; GO:0010319; GO:0009579; GO:0009407; GO:0005774 chloroplast envelope; chloroplast stroma; cytosol; defense response to bacterium; glutathione binding; glutathione transferase activity; nucleus; peroxidase activity; response to cold; response to karrikin; response to salt stress; response to toxic substance; stromule; thylakoid; toxin catabolic process; vacuolar membrane IPR010987; IPR004045; IPR004046; IPR012336; "Glutathione S-transferase F8, chloroplastic (AtGSTF8) (EC 2.5.1.18) (AtGSTF5) (GST class-phi member 8) (Glutathione S-transferase 6)" GSTF8 GST6 GSTF5 At2g47730 F17A22.12 Arabidopsis thaliana (Mouse-ear cress) TR14072_c1_g2_i1 P30568 GSTA_PLEPL 5.00E-34 GO:0005737; GO:0004364 cytoplasm; glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase A (GST-A) (EC 2.5.1.18) (GST class-theta) Pleuronectes platessa (European plaice) TR14076_c0_g2_i1 Q91YT0 NDUV1_MOUSE 5.00E-16 GO:0051539; GO:0010181; GO:0051287; GO:0008137; GO:0046872; GO:0005743; GO:0005747 "4 iron, 4 sulfur cluster binding; FMN binding; NAD binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; mitochondrial inner membrane; mitochondrial respiratory chain complex I" IPR001949; IPR019575; IPR011537; IPR011538; IPR019554; "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-51kD) (CI-51kD) (NADH-ubiquinone oxidoreductase 51 kDa subunit)" Ndufv1 Mus musculus (Mouse) TR14085_c0_g2_i1 Q9R0A3 SPAT7_RAT 5.00E-14 GO:0007283 spermatogenesis Spermatogenesis-associated protein 7 homolog (Fertility-related protein WMP1) (Rat sperm DNA no.3) (RSD-3) Spata7 Rsd3 Rattus norvegicus (Rat) TR14087_c1_g1_i1 Q9VZF4 FBXW7_DROME 6.00E-08 GO:0042023; GO:0019005; GO:0007411; GO:0035147; GO:0071456; GO:0030332; GO:0008054; GO:1900038; GO:0060253; GO:0045926; GO:0005634; GO:0016567; GO:0007096; GO:0030162; GO:0060438 Q9W4S7 "DNA endoreduplication; SCF ubiquitin ligase complex; axon guidance; branch fusion, open tracheal system; cellular response to hypoxia; cyclin binding; cyclin catabolic process; negative regulation of cellular response to hypoxia; negative regulation of glial cell proliferation; negative regulation of growth; nucleus; protein ubiquitination; regulation of exit from mitosis; regulation of proteolysis; trachea development" IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (Protein archipelago) ago CG15010 Drosophila melanogaster (Fruit fly) TR14095_c0_g1_i1 P34727 ARF_AJECA 8.00E-18 GO:0005525; GO:0005794; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor ARF Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum) TR14100_c2_g1_i2 A8C750 THADA_CANFA 1.00E-12 IPR016024; IPR019442; Thyroid adenoma-associated protein homolog THADA Canis familiaris (Dog) (Canis lupus familiaris) TR14102_c0_g1_i1 Q9JLJ0 LITAF_MOUSE 1.00E-08 GO:0005794; GO:0050699; GO:0006915; GO:0071222; GO:0005765; GO:0042347; GO:0005886; GO:0043123; GO:0001817; GO:0006355; GO:0004871; GO:0006351 P46935 "Golgi apparatus; WW domain binding; apoptotic process; cellular response to lipopolysaccharide; lysosomal membrane; negative regulation of NF-kappaB import into nucleus; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of cytokine production; regulation of transcription, DNA-dependent; signal transducer activity; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Estrogen-enhanced transcript protein) (mEET) (LITAF-like protein) (NEDD4 WW domain-binding protein 3) Litaf N4wbp3 Tbx1 Mus musculus (Mouse) TR14103_c0_g1_i1 P08228 SODC_MOUSE 5.00E-31 GO:0000187; GO:0007568; GO:0008089; GO:0060088; GO:0007569; GO:0006879; GO:0051087; GO:0005507; GO:0031410; GO:0005829; GO:0032839; GO:0007566; GO:0031012; GO:0005615; GO:0006749; GO:0060047; GO:0050665; GO:0007626; GO:0005739; GO:0046716; GO:0002262; GO:0045541; GO:0043524; GO:0060052; GO:0043025; GO:0005634; GO:0001541; GO:0032287; GO:0005777; GO:0005886; GO:0001819; GO:1902177; GO:0032930; GO:0043234; GO:0030346; GO:0032314; GO:0008217; GO:0051881; GO:0040014; GO:0060087; GO:0019430; GO:0001975; GO:0048678; GO:0046688; GO:0042493; GO:0045471; GO:0009408; GO:0042542; GO:0031667; GO:0001895; GO:0008090; GO:0007605; GO:0007283; GO:0042554; GO:0004784; GO:0008270 P63001 activation of MAPK activity; aging; anterograde axon cargo transport; auditory receptor cell stereocilium organization; cell aging; cellular iron ion homeostasis; chaperone binding; copper ion binding; cytoplasmic vesicle; cytosol; dendrite cytoplasm; embryo implantation; extracellular matrix; extracellular space; glutathione metabolic process; heart contraction; hydrogen peroxide biosynthetic process; locomotory behavior; mitochondrion; muscle cell cellular homeostasis; myeloid cell homeostasis; negative regulation of cholesterol biosynthetic process; negative regulation of neuron apoptotic process; neurofilament cytoskeleton organization; neuronal cell body; nucleus; ovarian follicle development; peripheral nervous system myelin maintenance; peroxisome; plasma membrane; positive regulation of cytokine production; positive regulation of intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of superoxide anion generation; protein complex; protein phosphatase 2B binding; regulation of Rac GTPase activity; regulation of blood pressure; regulation of mitochondrial membrane potential; regulation of multicellular organism growth; relaxation of vascular smooth muscle; removal of superoxide radicals; response to amphetamine; response to axon injury; response to copper ion; response to drug; response to ethanol; response to heat; response to hydrogen peroxide; response to nutrient levels; retina homeostasis; retrograde axon cargo transport; sensory perception of sound; spermatogenesis; superoxide anion generation; superoxide dismutase activity; zinc ion binding IPR024134; IPR018152; IPR001424; Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) Sod1 Mus musculus (Mouse) TR14103_c3_g1_i1 O74423 ENT1_SCHPO 3.00E-09 GO:0005096; GO:0030479; GO:0000147; GO:0007015; GO:0030276; GO:0006897; GO:0016020; GO:0005546; GO:0043130 "GTPase activator activity; actin cortical patch; actin cortical patch assembly; actin filament organization; clathrin binding; endocytosis; membrane; phosphatidylinositol-4,5-bisphosphate binding; ubiquitin binding" IPR013182; IPR008942; IPR013809; IPR001026; IPR003903; Epsin-1 ent1 SPCC162.07 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR14105_c0_g1_i1 Q86WI1 PKHL1_HUMAN 5.00E-41 GO:0005829; GO:0005615; GO:0006955; GO:0016021; GO:0004872 cytosol; extracellular space; immune response; integral to membrane; receptor activity IPR008972; IPR019316; IPR013783; IPR014756; IPR002909; IPR011658; IPR006626; IPR011050; Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) PKHD1L1 Homo sapiens (Human) TR14108_c0_g1_i1 Q76NI1 VKIND_HUMAN 6.00E-06 GO:0005088; GO:0021707; GO:0030425; GO:0032045; GO:0043025; GO:0001934; GO:0004674; GO:0048814; GO:0051056; GO:0007264 Ras guanyl-nucleotide exchange factor activity; cerebellar granule cell differentiation; dendrite; guanyl-nucleotide exchange factor complex; neuronal cell body; positive regulation of protein phosphorylation; protein serine/threonine kinase activity; regulation of dendrite morphogenesis; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR011009; IPR011019; IPR000651; IPR023578; IPR001895; Protein very KIND (Cerebral protein 9) (KIND domain-containing protein 1) (Kinase non-catalytic C-lobe domain-containing protein 1) (Ras-GEF domain-containing family member 2) KNDC1 C10orf23 KIAA1768 RASGEF2 VKIND hucep-9 Homo sapiens (Human) TR14109_c1_g1_i1 Q0IHQ9 ACPL2_XENTR 3.00E-22 GO:0003993; GO:0005576 acid phosphatase activity; extracellular region IPR000560; Acid phosphatase-like protein 2 (EC 3.1.3.2) acpl2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR14110_c0_g1_i1 Q6ZUK4 TMM26_HUMAN 7.00E-14 GO:0016021 integral to membrane IPR019169; Transmembrane protein 26 TMEM26 Homo sapiens (Human) TR14113_c1_g1_i1 Q9JLC8 SACS_MOUSE 5.00E-08 GO:0005524; GO:0050750; GO:0005739; GO:0090084; GO:0005634 ATP binding; low-density lipoprotein particle receptor binding; mitochondrion; negative regulation of inclusion body assembly; nucleus IPR001623; IPR003594; IPR007842; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) TR14116_c0_g1_i1 O77460 IPYR_DROME 2.00E-32 GO:0016589; GO:0005737; GO:0035076; GO:0004427; GO:0000287; GO:0042766; GO:0006796; GO:0045747; GO:0035206; GO:0006355; GO:0006351 "NURF complex; cytoplasm; ecdysone receptor-mediated signaling pathway; inorganic diphosphatase activity; magnesium ion binding; nucleosome mobilization; phosphate-containing compound metabolic process; positive regulation of Notch signaling pathway; regulation of hemocyte proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR008162; Inorganic pyrophosphatase (EC 3.6.1.1) (Nucleosome-remodeling factor 38 kDa subunit) (Pyrophosphate phospho-hydrolase) (PPase) Nurf-38 CG4634 Drosophila melanogaster (Fruit fly) TR14118_c3_g1_i1 Q80TL7 MON2_MOUSE 2.00E-69 GO:0005086; GO:0006895; GO:0030036; GO:0015031; GO:0005802 ARF guanyl-nucleotide exchange factor activity; Golgi to endosome transport; actin cytoskeleton organization; protein transport; trans-Golgi network IPR011989; IPR016024; IPR015403; IPR026829; Protein MON2 homolog (Protein SF21) Mon2 Kiaa1040 Sf21 Mus musculus (Mouse) TR14122_c0_g1_i2 O97741 SCNNA_RABIT 1.00E-14 GO:0016324; GO:0016021; GO:0015280; GO:0050896; GO:0050909; GO:0035725 apical plasma membrane; integral to membrane; ligand-gated sodium channel activity; response to stimulus; sensory perception of taste; sodium ion transmembrane transport IPR004724; IPR001873; IPR020903; Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA) SCNN1A Oryctolagus cuniculus (Rabbit) TR14127_c1_g1_i1 Q60636 PRDM1_MOUSE 3.00E-23 GO:0003677; GO:0045165; GO:0005737; GO:0042462; GO:0007281; GO:0042826; GO:0001893; GO:0046872; GO:0008168; GO:0007275; GO:0030889; GO:0031665; GO:0000122; GO:0005634; GO:0045579; GO:0010628; GO:0006355; GO:0043565; GO:0006351; GO:0060707 P63165 "DNA binding; cell fate commitment; cytoplasm; eye photoreceptor cell development; germ cell development; histone deacetylase binding; maternal placenta development; metal ion binding; methyltransferase activity; multicellular organismal development; negative regulation of B cell proliferation; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of B cell differentiation; positive regulation of gene expression; regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription, DNA-dependent; trophoblast giant cell differentiation" IPR001214; IPR007087; IPR015880; IPR013087; IPR016608; PR domain zinc finger protein 1 (EC 2.1.1.-) (B lymphocyte-induced maturation protein 1) (Blimp-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) Prdm1 Blimp1 Mus musculus (Mouse) TR14148_c0_g2_i1 A8MXQ7 YH010_HUMAN 1.00E-10 IPR002110; IPR020683; IPR000048; Putative IQ motif and ankyrin repeat domain-containing protein LOC642574 Homo sapiens (Human) TR14149_c0_g1_i1 O60522 TDRD6_HUMAN 7.00E-11 GO:0043186; GO:0033391; GO:0005783; GO:0007281; GO:0007275; GO:0007283 P granule; chromatoid body; endoplasmic reticulum; germ cell development; multicellular organismal development; spermatogenesis IPR002999; Tudor domain-containing protein 6 (Antigen NY-CO-45) (Cancer/testis antigen 41.2) (CT41.2) TDRD6 Homo sapiens (Human) TR14150_c0_g1_i1 O01761 UNC89_CAEEL 2.00E-13 GO:0005524; GO:0031430; GO:0005089; GO:0005543; GO:0004672; GO:0035023; GO:0030241 ATP binding; M band; Rho guanyl-nucleotide exchange factor activity; phospholipid binding; protein kinase activity; regulation of Rho protein signal transduction; skeletal muscle myosin thick filament assembly IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR007850; IPR001452; Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans TR14150_c0_g2_i1 Q15746 MYLK_HUMAN 5.00E-12 GO:0005524; GO:0060414; GO:0032060; GO:0071476; GO:0032154; GO:0005829; GO:0030027; GO:0046872; GO:0004687; GO:0005886; GO:0051928; GO:0030335; GO:0090303; GO:0001725; GO:0014820 P16333 ATP binding; aorta smooth muscle tissue morphogenesis; bleb assembly; cellular hypotonic response; cleavage furrow; cytosol; lamellipodium; metal ion binding; myosin light chain kinase activity; plasma membrane; positive regulation of calcium ion transport; positive regulation of cell migration; positive regulation of wound healing; stress fiber; tonic smooth muscle contraction IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR020675; IPR000719; IPR017441; IPR002290; IPR008271; "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]" MYLK MLCK MLCK1 MYLK1 Homo sapiens (Human) TR14158_c1_g1_i1 Q9CYI4 LUC7L_MOUSE 8.00E-14 GO:0005685; GO:0003729; GO:0006376; GO:0045843; GO:0005634 U1 snRNP; mRNA binding; mRNA splice site selection; negative regulation of striated muscle tissue development; nucleus IPR004882; Putative RNA-binding protein Luc7-like 1 Luc7l Mus musculus (Mouse) TR14162_c1_g1_i1 Q8IV33 K0825_HUMAN 1.00E-42 IPR027993; Uncharacterized protein KIAA0825 KIAA0825 C5orf36 Homo sapiens (Human) TR14163_c3_g1_i1 Q28HF6 LNP_XENTR 3.00E-30 GO:0016021 integral to membrane IPR019273; Protein lunapark lnp TEgg059h15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR14165_c3_g1_i1 P61210 ARF1_LOCMI 7.00E-55 GO:0005525; GO:0005794; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor 1 (lARF1) ARF1 Locusta migratoria (Migratory locust) TR14183_c1_g1_i1 Q27256 WHITE_ANOGA 1.00E-73 GO:0005524; GO:0006200; GO:0016887; GO:0016021; GO:0031409; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; integral to membrane; pigment binding; transport IPR003593; IPR013525; IPR003439; IPR017871; IPR027417; IPR005284; Protein white w AGAP000553 Anopheles gambiae (African malaria mosquito) TR14183_c1_g2_i1 O07190 FLQE1_MYCTU 2.00E-11 GO:0005524; GO:0006200; GO:0016887; GO:0042891; GO:0015562; GO:0005886; GO:0046677 ATP binding; ATP catabolic process; ATPase activity; antibiotic transport; efflux transmembrane transporter activity; plasma membrane; response to antibiotic IPR003593; IPR003439; IPR027417; Fluoroquinolones export ATP-binding protein Rv2688c/MT2762 (EC 3.6.3.-) Rv2688c MT2762 Mycobacterium tuberculosis TR1419_c0_g1_i1 Q3U898 MYOV2_MOUSE 4.00E-16 Myeloma-overexpressed gene 2 protein homolog Myeov2 Mus musculus (Mouse) TR14197_c1_g1_i1 Q8BZN6 DOC10_MOUSE 2.00E-14 GO:0005089; GO:0005543; GO:0007264 Rho guanyl-nucleotide exchange factor activity; phospholipid binding; small GTPase mediated signal transduction IPR016024; IPR027007; IPR027357; IPR026791; IPR010703; IPR021816; IPR026796; IPR011993; IPR001849; Dedicator of cytokinesis protein 10 (Zizimin-3) Dock10 Kiaa0694 Ziz3 Mus musculus (Mouse) TR14197_c3_g1_i1 Q8BIK4 DOCK9_MOUSE 6.00E-21 GO:0005089; GO:0012505; GO:0016020; GO:0005543; GO:0007264 Rho guanyl-nucleotide exchange factor activity; endomembrane system; membrane; phospholipid binding; small GTPase mediated signal transduction IPR016024; IPR027007; IPR027357; IPR026791; IPR010703; IPR021816; IPR026796; IPR011993; IPR001849; Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) Dock9 D14Wsu89e Kiaa1058 Mus musculus (Mouse) TR14198_c0_g1_i1 Q5RI75 RASEF_MOUSE 3.00E-24 GO:0005525; GO:0048471; GO:0015031; GO:0007264 GTP binding; perinuclear region of cytoplasm; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras and EF-hand domain-containing protein homolog Rasef Mus musculus (Mouse) TR14207_c0_g1_i1 Q5YLM1 DGLA_RAT 7.00E-18 GO:0019369; GO:0071926; GO:0016021; GO:0016042; GO:0046872; GO:0007405; GO:0042136; GO:0005886; GO:0004806 arachidonic acid metabolic process; endocannabinoid signaling pathway; integral to membrane; lipid catabolic process; metal ion binding; neuroblast proliferation; neurotransmitter biosynthetic process; plasma membrane; triglyceride lipase activity IPR002921; Sn1-specific diacylglycerol lipase alpha (DGL-alpha) (EC 3.1.1.-) (Neural stem cell-derived dendrite regulator) Dagla Nsddr Rattus norvegicus (Rat) TR14215_c1_g1_i1 P27590 UROM_RAT 5.00E-14 GO:0005794; GO:0031225; GO:0016324; GO:0016323; GO:0005509; GO:0048878; GO:0060170; GO:0016023; GO:0007588; GO:0005615; GO:0045121; GO:0072218; GO:0072221; GO:0072233; GO:0072372; GO:2000021; GO:0010033; GO:0000922 Golgi apparatus; anchored to membrane; apical plasma membrane; basolateral plasma membrane; calcium ion binding; chemical homeostasis; cilium membrane; cytoplasmic membrane-bounded vesicle; excretion; extracellular space; membrane raft; metanephric ascending thin limb development; metanephric distal convoluted tubule development; metanephric thick ascending limb development; primary cilium; regulation of ion homeostasis; response to organic substance; spindle pole IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR023413; IPR009030; IPR001507; IPR017977; "Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]" Umod Rattus norvegicus (Rat) TR14215_c2_g1_i1 P19218 GP2_RAT 1.00E-16 GO:0031225; GO:0005576; GO:0005886 anchored to membrane; extracellular region; plasma membrane IPR001507; IPR017977; Pancreatic secretory granule membrane major glycoprotein GP2 (Glycoprotein 80) (gp80) (Pancreatic zymogen granule membrane protein GP-2) Gp2 Rattus norvegicus (Rat) TR14235_c4_g1_i1 P26041 MOES_MOUSE 1.00E-13 GO:0016324; GO:0016323; GO:0005737; GO:0005856; GO:0003725; GO:0070062; GO:0019898; GO:0030175; GO:0005925; GO:0007159; GO:0050900; GO:0022614; GO:0031528; GO:0005730; GO:2000401; GO:0001931 apical plasma membrane; basolateral plasma membrane; cytoplasm; cytoskeleton; double-stranded RNA binding; extracellular vesicular exosome; extrinsic to membrane; filopodium; focal adhesion; leukocyte cell-cell adhesion; leukocyte migration; membrane to membrane docking; microvillus membrane; nucleolus; regulation of lymphocyte migration; uropod IPR019749; IPR019750; IPR011174; IPR011259; IPR000798; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR008954; IPR011993; Moesin (Membrane-organizing extension spike protein) Msn Mus musculus (Mouse) TR14239_c1_g1_i1 Q8K0U4 HS12A_MOUSE 4.00E-12 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR14240_c0_g1_i1 Q8NHV1 GIMA7_HUMAN 2.00E-18 GO:0005525; GO:0003924; GO:0005811 GTP binding; GTPase activity; lipid particle IPR006703; IPR027417; GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) TR14242_c0_g1_i1 E9Q7X6 HEG1_MOUSE 7.00E-13 GO:0005509; GO:0003209; GO:0005911; GO:0045216; GO:0001886; GO:0009897; GO:0001701; GO:0016021; GO:0030324; GO:0003017; GO:0001945; GO:0035264; GO:0060039; GO:0009791; GO:0050878; GO:0001570; GO:0048845; GO:0003281 calcium ion binding; cardiac atrium morphogenesis; cell-cell junction; cell-cell junction organization; endothelial cell morphogenesis; external side of plasma membrane; in utero embryonic development; integral to membrane; lung development; lymph circulation; lymph vessel development; multicellular organism growth; pericardium development; post-embryonic development; regulation of body fluid levels; vasculogenesis; venous blood vessel morphogenesis; ventricular septum development IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; Protein HEG homolog 1 Heg1 Mus musculus (Mouse) TR14242_c1_g1_i1 Q6V0I7 FAT4_HUMAN 4.00E-21 GO:0005509; GO:0007156; GO:0016021; GO:0005886 Q9H2K2 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) TR14250_c3_g1_i1 Q5ZIJ9 MIB2_CHICK 4.00E-19 GO:0007219; GO:0005737; GO:0004842; GO:0008270 Notch signaling pathway; cytoplasm; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) TR14252_c0_g1_i1 Q9U641 CMFB_DICDI 3.00E-23 GO:0016021; GO:0055114; GO:0016491 integral to membrane; oxidation-reduction process; oxidoreductase activity IPR002938; IPR003042; Conditioned medium factor receptor 1 cmfB cmfr1 DDB_G0289157 Dictyostelium discoideum (Slime mold) TR14255_c0_g1_i1 Q91318 CRBB2_LITCT 5.00E-11 GO:0005212 structural constituent of eye lens IPR001064; IPR011024; Beta-crystallin B2 (Beta-B2 crystallin) (Beta-crystallin Bp) Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) TR14255_c1_g1_i1 Q8WXF5 CRGN_HUMAN 9.00E-06 IPR001064; IPR011024; Gamma-crystallin N (Gamma-N-crystallin) CRYGN Homo sapiens (Human) TR14281_c0_g1_i1 Q6P011 EMC4_DANRE 2.00E-38 GO:0072546 ER membrane protein complex IPR009445; ER membrane protein complex subunit 4 (Transmembrane protein 85) emc4 tmem85 zgc:77852 Danio rerio (Zebrafish) (Brachydanio rerio) TR14287_c0_g1_i1 Q9BYG5 PAR6B_HUMAN 5.00E-23 GO:0045177; GO:0007409; GO:0005938; GO:0007049; GO:0051301; GO:0005829; GO:0007163; GO:0005634; GO:0005886; GO:0043234; GO:0006461; GO:0030334; GO:0005923; GO:0070830 P60953; Q8TEW0; Q8ND90; P41743; Q05513; P63000; Q04917 apical part of cell; axonogenesis; cell cortex; cell cycle; cell division; cytosol; establishment or maintenance of cell polarity; nucleus; plasma membrane; protein complex; protein complex assembly; regulation of cell migration; tight junction; tight junction assembly IPR000270; IPR001478; Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B) PARD6B PAR6B Homo sapiens (Human) TR14289_c0_g1_i1 Q0JKV1 AKT1_ORYSJ 8.00E-07 GO:0016021; GO:0005249 integral to membrane; voltage-gated potassium channel activity IPR002110; IPR020683; IPR018490; IPR000595; IPR005821; IPR021789; IPR003938; IPR014710; Potassium channel AKT1 (OsAKT1) AKT1 Os01g0648000 LOC_Os01g45990 Oryza sativa subsp. japonica (Rice) TR1429_c0_g1_i1 P33248 TYB12_LATJA 1.00E-13 GO:0030036; GO:0005737; GO:0005856; GO:0042989 actin cytoskeleton organization; cytoplasm; cytoskeleton; sequestering of actin monomers IPR001152; IPR016323; Thymosin beta-12 Lateolabrax japonicus (Japanese sea perch) (Japanese sea bass) TR14298_c1_g1_i1 Q7KLV9 PSD11_DROME 3.00E-29 GO:0005875; GO:0043161; GO:0008541 "microtubule associated complex; proteasomal ubiquitin-dependent protein catabolic process; proteasome regulatory particle, lid subcomplex" IPR013143; IPR000717; IPR011990; IPR011991; 26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory complex subunit p42B) (26S proteasome regulatory subunit Rpn6) Rpn6 CG10149 Drosophila melanogaster (Fruit fly) TR14308_c0_g1_i1 Q865U8 ANKR1_PIG 1.00E-21 GO:0003677; GO:0031674; GO:0001105; GO:0055008; GO:0035690; GO:0071347; GO:0071222; GO:0071260; GO:0071560; GO:0071356; GO:0005829; GO:2000279; GO:0005634; GO:0048471; GO:0043517; GO:0043065; GO:0050714; GO:0035994; GO:0035914; GO:0003714; GO:0005667 "DNA binding; I band; RNA polymerase II transcription coactivator activity; cardiac muscle tissue morphogenesis; cellular response to drug; cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; cytosol; negative regulation of DNA biosynthetic process; nucleus; perinuclear region of cytoplasm; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of apoptotic process; positive regulation of protein secretion; response to muscle stretch; skeletal muscle cell differentiation; transcription corepressor activity; transcription factor complex" IPR002110; IPR020683; Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) ANKRD1 CARP Sus scrofa (Pig) TR14319_c0_g1_i1 Q8TCA0 LRC20_HUMAN 7.00E-07 IPR001611; Leucine-rich repeat-containing protein 20 LRRC20 UNQ2429/PRO4989 Homo sapiens (Human) TR14321_c0_g1_i1 Q17LW0 MYO7A_AEDAE 1.00E-88 GO:0005524; GO:0030048; GO:0030898; GO:0048800; GO:0008407; GO:0005737; GO:0035317; GO:0003774; GO:0016459; GO:0032027; GO:0007605 ATP binding; actin filament-based movement; actin-dependent ATPase activity; antennal morphogenesis; chaeta morphogenesis; cytoplasm; imaginal disc-derived wing hair organization; motor activity; myosin complex; myosin light chain binding; sensory perception of sound IPR019749; IPR014352; IPR019748; IPR000299; IPR018979; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; IPR001452; Myosin-VIIa (Protein crinkled) ck AAEL001220 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR14328_c4_g1_i1 B4HF64 FOXO_DROSE 1.00E-52 GO:0007049; GO:0030154; GO:0005737; GO:0042593; GO:0010259; GO:0030308; GO:0008285; GO:0046627; GO:0005634; GO:0019216; GO:0043565; GO:0003700; GO:0006351 "cell cycle; cell differentiation; cytoplasm; glucose homeostasis; multicellular organismal aging; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of insulin receptor signaling pathway; nucleus; regulation of lipid metabolic process; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; Forkhead box protein O foxo GM24148 Drosophila sechellia (Fruit fly) TR1433_c0_g1_i1 Q9VLT5 POE_DROME 1.00E-08 GO:0005516; GO:0042066; GO:0016567; GO:0050896; GO:0007291; GO:0004842; GO:0007601; GO:0008270 calmodulin binding; perineurial glial growth; protein ubiquitination; response to stimulus; sperm individualization; ubiquitin-protein ligase activity; visual perception; zinc ion binding IPR025704; IPR017986; IPR003126; IPR013993; Protein purity of essence (Interaction calmodulin and colossal molecular mass protein) (Protein Calossin) (Protein pushover) poe calo push CG14472 Drosophila melanogaster (Fruit fly) TR14333_c1_g1_i1 Q5R686 CLIP3_PONAB 5.00E-10 GO:0005795; GO:0072321; GO:0031901; GO:0045444; GO:0035594; GO:0044091; GO:0045121; GO:0008017; GO:0031115; GO:0018230; GO:0005886; GO:0043065; GO:0045807; GO:0090004; GO:0010828; GO:0001934; GO:0055038; GO:0032588 Golgi stack; chaperone-mediated protein transport; early endosome membrane; fat cell differentiation; ganglioside binding; membrane biogenesis; membrane raft; microtubule binding; negative regulation of microtubule polymerization; peptidyl-L-cysteine S-palmitoylation; plasma membrane; positive regulation of apoptotic process; positive regulation of endocytosis; positive regulation of establishment of protein localization to plasma membrane; positive regulation of glucose transport; positive regulation of protein phosphorylation; recycling endosome membrane; trans-Golgi network membrane IPR002110; IPR020683; IPR000938; CAP-Gly domain-containing linker protein 3 (Cytoplasmic linker protein 170-related 59 kDa protein) (CLIP-170-related 59 kDa protein) (CLIPR-59) CLIP3 CLIPR59 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR14335_c1_g1_i1 Q63120 MRP2_RAT 3.00E-29 GO:0005524; GO:0006200; GO:0042626; GO:0016324; GO:0030644; GO:0006855; GO:0005887; GO:0046581; GO:0008514; GO:0015732; GO:0046685; GO:0043627; GO:0009408; GO:0031427; GO:0006979; GO:0070327 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; apical plasma membrane; cellular chloride ion homeostasis; drug transmembrane transport; integral to plasma membrane; intercellular canaliculus; organic anion transmembrane transporter activity; prostaglandin transport; response to arsenic-containing substance; response to estrogen stimulus; response to heat; response to methotrexate; response to oxidative stress; thyroid hormone transport" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Canalicular multispecific organic anion transporter 1 (ATP-binding cassette sub-family C member 2) (Canalicular multidrug resistance protein) (Multidrug resistance-associated protein 2) Abcc2 Cmoat Cmrp Mrp2 Rattus norvegicus (Rat) TR14348_c1_g1_i1 P20585 MSH3_HUMAN 1.00E-30 GO:0005524; GO:0008094; GO:0032302; GO:0000403; GO:0019237; GO:0003684; GO:0000406; GO:0000404; GO:0043570; GO:0000710; GO:0045910; GO:0000228; GO:0051096; GO:0007131; GO:0016447 P43246 ATP binding; DNA-dependent ATPase activity; MutSbeta complex; Y-form DNA binding; centromeric DNA binding; damaged DNA binding; double-strand/single-strand DNA junction binding; loop DNA binding; maintenance of DNA repeat elements; meiotic mismatch repair; negative regulation of DNA recombination; nuclear chromosome; positive regulation of helicase activity; reciprocal meiotic recombination; somatic recombination of immunoglobulin gene segments IPR007695; IPR000432; IPR007861; IPR007696; IPR016151; IPR007860; IPR027417; DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1) MSH3 DUC1 DUG Homo sapiens (Human) TR14349_c1_g1_i1 O43301 HS12A_HUMAN 2.00E-20 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR14353_c0_g1_i1 Q497B2 TM45B_RAT 1.00E-10 GO:0016021 integral to membrane IPR006904; Transmembrane protein 45B Tmem45b Rattus norvegicus (Rat) TR14353_c1_g1_i1 Q96B21 TM45B_HUMAN 1.00E-09 GO:0016021 integral to membrane IPR006904; Transmembrane protein 45B TMEM45B Homo sapiens (Human) TR14360_c0_g2_i1 Q13489 BIRC3_HUMAN 1.00E-11 GO:0038061; GO:0035666; GO:0006915; GO:0007166; GO:0005829; GO:0045087; GO:0070266; GO:0043066; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0043123; GO:0039535; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0034138; GO:0034142; GO:0004842; GO:0008270 Q13546; O43353; Q9Y572; P57078; Q12933 NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; apoptotic process; cell surface receptor signaling pathway; cytosol; innate immune response; necroptosis; negative regulation of apoptotic process; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of RIG-I signaling pathway; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Apoptosis inhibitor 2) (API2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (IAP-1) (hIAP-1) (hIAP1) (RING finger protein 49) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 IAP1 MIHC RNF49 Homo sapiens (Human) TR14363_c0_g1_i1 Q9VXG8 ATR_DROME 9.00E-07 GO:0005524; GO:0003677; GO:0007015; GO:0007349; GO:0030261; GO:0045002; GO:0045003; GO:0001700; GO:0016321; GO:0007444; GO:0000706; GO:0033314; GO:0007095; GO:0005634; GO:0048477; GO:0004672; GO:0004674; GO:0007131; GO:0008360; GO:0007088; GO:0007348; GO:0009314; GO:0000723 ATP binding; DNA binding; actin filament organization; cellularization; chromosome condensation; double-strand break repair via single-strand annealing; double-strand break repair via synthesis-dependent strand annealing; embryonic development via the syncytial blastoderm; female meiosis chromosome segregation; imaginal disc development; meiotic DNA double-strand break processing; mitotic DNA replication checkpoint; mitotic G2 DNA damage checkpoint; nucleus; oogenesis; protein kinase activity; protein serine/threonine kinase activity; reciprocal meiotic recombination; regulation of cell shape; regulation of mitosis; regulation of syncytial blastoderm mitotic cell cycle; response to radiation; telomere maintenance IPR016024; IPR003152; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR011990; IPR012993; Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein homolog) (ATR homolog) (dATR) (Meiotic protein 41) mei-41 CG4252 Drosophila melanogaster (Fruit fly) TR14363_c1_g1_i1 Q13535 ATR_HUMAN 4.00E-28 GO:0005524; GO:0003677; GO:0000077; GO:0006281; GO:0006260; GO:0032405; GO:0032407; GO:0016605; GO:0001741; GO:0034644; GO:0071480; GO:0005694; GO:0007275; GO:0008156; GO:0005654; GO:0018105; GO:0043517; GO:0046777; GO:0004674; GO:0043393; GO:0090399 Q99459; P50750; Q9Y6K9; O43156 "ATP binding; DNA binding; DNA damage checkpoint; DNA repair; DNA replication; MutLalpha complex binding; MutSalpha complex binding; PML body; XY body; cellular response to UV; cellular response to gamma radiation; chromosome; multicellular organismal development; negative regulation of DNA replication; nucleoplasm; peptidyl-serine phosphorylation; positive regulation of DNA damage response, signal transduction by p53 class mediator; protein autophosphorylation; protein serine/threonine kinase activity; regulation of protein binding; replicative senescence" IPR011989; IPR016024; IPR003152; IPR021133; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR011990; IPR012993; Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1) ATR FRP1 Homo sapiens (Human) TR14365_c0_g1_i1 Q94126 CES2_CAEEL 8.00E-18 GO:0001012; GO:0006915; GO:0005634; GO:0043068; GO:0043565; GO:0003700; GO:0006351 "RNA polymerase II regulatory region DNA binding; apoptotic process; nucleus; positive regulation of programmed cell death; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; Cell death specification protein 2 ces-2 ZK909.4 Caenorhabditis elegans TR14369_c3_g1_i1 Q2WGJ6 KLH38_HUMAN 7.00E-20 P08238 IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 38 KLHL38 C8orfK36 Homo sapiens (Human) TR14372_c1_g1_i1 O76039 CDKL5_HUMAN 6.00E-36 GO:0005524; GO:0048365; GO:0004693; GO:0032839; GO:0044294; GO:0001764; GO:0005634; GO:0032855; GO:0045773; GO:0050775; GO:0046777; GO:0004674 ATP binding; Rac GTPase binding; cyclin-dependent protein serine/threonine kinase activity; dendrite cytoplasm; dendritic growth cone; neuron migration; nucleus; positive regulation of Rac GTPase activity; positive regulation of axon extension; positive regulation of dendrite morphogenesis; protein autophosphorylation; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9) CDKL5 STK9 Homo sapiens (Human) TR14374_c0_g1_i1 Q8ITC3 RS19_AEQIR 6.00E-71 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001266; IPR018277; IPR011991; 40S ribosomal protein S19 RPS19 Argopecten irradians (Bay scallop) (Aequipecten irradians) TR14380_c0_g1_i1 Q9BUY5 ZN426_HUMAN 3.00E-20 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 426 ZNF426 Homo sapiens (Human) TR14381_c1_g1_i1 Q9Y4D1 DAAM1_HUMAN 6.00E-48 GO:0030036; GO:0005737; GO:0005886; GO:0001725 Itself; Q5T0N5; P61586; P00523; Q15642-2 actin cytoskeleton organization; cytoplasm; plasma membrane; stress fiber IPR011989; IPR016024; IPR027650; IPR014767; IPR015425; IPR010472; IPR010473; IPR014768; Disheveled-associated activator of morphogenesis 1 DAAM1 KIAA0666 Homo sapiens (Human) TR14382_c0_g1_i1 Q9PU85 PIM3_COTJA 9.00E-127 GO:0005524; GO:0005737; GO:0004674 ATP binding; cytoplasm; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase pim-3 (EC 2.7.11.1) (qpim) PIM3 PIM-3 Coturnix coturnix japonica (Japanese quail) (Coturnix japonica) TR14395_c1_g1_i1 O94988 FA13A_HUMAN 2.00E-30 GO:0005096; GO:0005829; GO:0043547; GO:0051056; GO:0007264 GTPase activator activity; cytosol; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR008936; IPR000198; Protein FAM13A FAM13A FAM13A1 KIAA0914 Homo sapiens (Human) TR14403_c0_g2_i1 Q8NCM8 DYHC2_HUMAN 5.00E-60 GO:0005524; GO:0006200; GO:0016887; GO:0005794; GO:0007030; GO:0019886; GO:0045177; GO:0008105; GO:0001539; GO:0042384; GO:0035085; GO:0005829; GO:0007368; GO:0009953; GO:0030286; GO:0030326; GO:0030900; GO:0005874; GO:0003777; GO:0007018; GO:0031512; GO:0003774; GO:0005886; GO:0016485; GO:0021522 ATP binding; ATP catabolic process; ATPase activity; Golgi apparatus; Golgi organization; antigen processing and presentation of exogenous peptide antigen via MHC class II; apical part of cell; asymmetric protein localization; ciliary or bacterial-type flagellar motility; cilium assembly; cilium axoneme; cytosol; determination of left/right symmetry; dorsal/ventral pattern formation; dynein complex; embryonic limb morphogenesis; forebrain development; microtubule; microtubule motor activity; microtubule-based movement; motile primary cilium; motor activity; plasma membrane; protein processing; spinal cord motor neuron differentiation IPR003593; IPR011704; IPR026983; IPR026815; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; Cytoplasmic dynein 2 heavy chain 1 (Cytoplasmic dynein 2 heavy chain) (Dynein cytoplasmic heavy chain 2) (Dynein heavy chain 11) (hDHC11) (Dynein heavy chain isotype 1B) DYNC2H1 DHC1B DHC2 DNCH2 DYH1B KIAA1997 Homo sapiens (Human) TR14403_c1_g1_i1 Q19542 DYHC2_CAEEL 1.00E-19 GO:0005524; GO:0006200; GO:0016887; GO:0007635; GO:0001539; GO:0005929; GO:0042384; GO:0060170; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018; GO:0007275; GO:0030512; GO:0008104 ATP binding; ATP catabolic process; ATPase activity; chemosensory behavior; ciliary or bacterial-type flagellar motility; cilium; cilium assembly; cilium membrane; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement; multicellular organismal development; negative regulation of transforming growth factor beta receptor signaling pathway; protein localization IPR003593; IPR011704; IPR026983; IPR026815; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; Cytoplasmic dynein 2 heavy chain 1 (Abnormal chemotaxis protein 3) che-3 F18C12.1 Caenorhabditis elegans TR14423_c0_g1_i1 Q3UP23 TMM26_MOUSE 5.00E-09 GO:0016021 integral to membrane IPR019169; Transmembrane protein 26 Tmem26 Mus musculus (Mouse) TR14428_c1_g1_i1 G5E8K5 ANK3_MOUSE 1.00E-11 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR1444_c0_g1_i1 P63170 DYL1_RAT 1.00E-14 GO:0008180; GO:0006915; GO:0005813; GO:0005868; GO:0005829; GO:0004857; GO:0000776; GO:0016020; GO:0005874; GO:0007017; GO:0005739; GO:0072686; GO:0003774; GO:0042326; GO:0042133; GO:0006809; GO:0030235; GO:0042803; GO:0006355; GO:0006351; GO:0006810 "COP9 signalosome; apoptotic process; centrosome; cytoplasmic dynein complex; cytosol; enzyme inhibitor activity; kinetochore; membrane; microtubule; microtubule-based process; mitochondrion; mitotic spindle; motor activity; negative regulation of phosphorylation; neurotransmitter metabolic process; nitric oxide biosynthetic process; nitric-oxide synthase regulator activity; protein homodimerization activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent; transport" IPR019763; IPR001372; "Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN)" Dynll1 Dncl1 Dnclc1 Pin Rattus norvegicus (Rat) TR14444_c0_g1_i1 P38942 CAT2_CLOK5 2.00E-22 GO:0006084; GO:0016740 acetyl-CoA metabolic process; transferase activity IPR026888; IPR003702; 4-hydroxybutyrate coenzyme A transferase (EC 2.8.3.-) cat2 CKL_3018 Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) TR14446_c0_g2_i1 P42766 RL35_HUMAN 1.00E-46 GO:0006614; GO:0022625; GO:0003729; GO:0000184; GO:0005730; GO:0003735; GO:0006414; GO:0006413; GO:0006415; GO:0019083 O43586 "SRP-dependent cotranslational protein targeting to membrane; cytosolic large ribosomal subunit; mRNA binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleolus; structural constituent of ribosome; translational elongation; translational initiation; translational termination; viral transcription" IPR001854; IPR018254; 60S ribosomal protein L35 RPL35 Homo sapiens (Human) TR14455_c0_g2_i1 Q460N3 PAR15_HUMAN 7.00E-10 GO:0003950; GO:0005634; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) TR14458_c0_g1_i1 Q47944 SDH_GLUOY 2.00E-06 GO:0006066; GO:0008812; GO:0050660 alcohol metabolic process; choline dehydrogenase activity; flavin adenine dinucleotide binding IPR012132; IPR000172; IPR007867; L-sorbose 1-dehydrogenase (SDH) (EC 1.1.99.32) Gluconobacter oxydans (Gluconobacter suboxydans) TR14458_c1_g1_i1 P18172 DHGL_DROPS 2.00E-10 GO:0006066; GO:0008812; GO:0005576; GO:0050660 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR14460_c0_g1_i1 Q5E9S2 NFYA_BOVIN 8.00E-38 GO:0016602; GO:0003677; GO:0006355; GO:0003700; GO:0006351 "CCAAT-binding factor complex; DNA binding; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR018362; IPR001289; Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) NFYA Bos taurus (Bovine) TR14465_c0_g1_i1 Q6DJ83 CADM2_XENTR 6.00E-07 GO:0016021 integral to membrane IPR013162; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; IPR003585; Cell adhesion molecule 2 (Immunoglobulin superfamily member 4D) (IgSF4D) cadm2 igsf4d Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR14469_c0_g2_i1 Q3TUF7 YETS2_MOUSE 9.00E-26 GO:0005671; GO:0043966; GO:0072686; GO:0000122; GO:0005634 Ada2/Gcn5/Ada3 transcription activator complex; histone H3 acetylation; mitotic spindle; negative regulation of transcription from RNA polymerase II promoter; nucleus IPR005033; YEATS domain-containing protein 2 Yeats2 Kiaa1197 Mus musculus (Mouse) TR14471_c1_g1_i1 P18724 ZG49_XENLA 1.00E-17 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Gastrula zinc finger protein XlCGF49.1 (Fragment) Xenopus laevis (African clawed frog) TR14473_c0_g1_i1 Q91VS7 MGST1_MOUSE 3.00E-30 GO:0033327; GO:0045177; GO:0071449; GO:0005783; GO:0005789; GO:0043295; GO:0006749; GO:0004602; GO:0004364; GO:0016021; GO:0005743; GO:0005741; GO:0005634; GO:0005778; GO:0070207; GO:0042493; GO:0032496; GO:0010243 Leydig cell differentiation; apical part of cell; cellular response to lipid hydroperoxide; endoplasmic reticulum; endoplasmic reticulum membrane; glutathione binding; glutathione metabolic process; glutathione peroxidase activity; glutathione transferase activity; integral to membrane; mitochondrial inner membrane; mitochondrial outer membrane; nucleus; peroxisomal membrane; protein homotrimerization; response to drug; response to lipopolysaccharide; response to organonitrogen compound IPR023352; IPR001129; Microsomal glutathione S-transferase 1 (Microsomal GST-1) (EC 2.5.1.18) (Microsomal GST-I) Mgst1 Mus musculus (Mouse) TR14482_c0_g1_i1 Q3SYV7 ZN345_BOVIN 1.00E-20 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 345 ZNF345 Bos taurus (Bovine) TR14485_c4_g1_i1 Q9JLI3 MMEL1_MOUSE 4.00E-14 GO:0005794; GO:0005783; GO:0005615; GO:0016021; GO:0004222; GO:0006508; GO:0008270 Golgi apparatus; endoplasmic reticulum; extracellular space; integral to membrane; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR000718; IPR018497; IPR008753; "Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) (Neprilysin-like 1) (NL-1) (Neprilysin-like peptidase) (NEPLP) (Soluble secreted endopeptidase) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]" Mmel1 Nep2 Nl1 Sep Mus musculus (Mouse) TR14488_c0_g1_i1 Q04721 NOTC2_HUMAN 3.00E-19 GO:0000139; GO:0007220; GO:0061314; GO:0006915; GO:0060413; GO:0046849; GO:0005509; GO:0007050; GO:0001709; GO:0016049; GO:0009986; GO:0005789; GO:0005576; GO:0030097; GO:0005887; GO:0043066; GO:0008285; GO:0007399; GO:0005654; GO:0046579; GO:0003184; GO:0004872; GO:0006355; GO:0019827; GO:0006367 "Golgi membrane; Notch receptor processing; Notch signaling involved in heart development; apoptotic process; atrial septum morphogenesis; bone remodeling; calcium ion binding; cell cycle arrest; cell fate determination; cell growth; cell surface; endoplasmic reticulum membrane; extracellular region; hemopoiesis; integral to plasma membrane; negative regulation of apoptotic process; negative regulation of cell proliferation; nervous system development; nucleoplasm; positive regulation of Ras protein signal transduction; pulmonary valve morphogenesis; receptor activity; regulation of transcription, DNA-dependent; stem cell maintenance; transcription initiation from RNA polymerase II promoter" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022336; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation; Notch 2 intracellular domain] NOTCH2 Homo sapiens (Human) TR14489_c0_g1_i1 P05765 RS21_RAT 1.00E-40 GO:0022627; GO:0000447; GO:0000461; GO:0043022; GO:0003735; GO:0006414 "cytosolic small ribosomal subunit; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ribosome binding; structural constituent of ribosome; translational elongation" IPR001931; IPR018279; 40S ribosomal protein S21 Rps21 Rattus norvegicus (Rat) TR14496_c1_g1_i1 P58406 HRH3_MOUSE 2.00E-12 GO:0004969; GO:0016021; GO:0005886; GO:0001505 histamine receptor activity; integral to membrane; plasma membrane; regulation of neurotransmitter levels IPR000276; IPR017452; IPR003980; Histamine H3 receptor (H3R) (HH3R) Hrh3 Mus musculus (Mouse) TR14497_c0_g1_i1 P0C594 DUPD1_PANTR 2.00E-19 GO:0005737; GO:0035335; GO:0004725; GO:0008138 cytoplasm; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR020417; IPR020405; IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Dual specificity phosphatase DUPD1 (EC 3.1.3.16) (EC 3.1.3.48) DUPD1 Pan troglodytes (Chimpanzee) TR14498_c0_g1_i1 Q64323 PIGA_MOUSE 1.00E-12 GO:0006506; GO:0005789; GO:0000506; GO:0016021; GO:0016757 "GPI anchor biosynthetic process; endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; integral to membrane; transferase activity, transferring glycosyl groups" IPR001296; IPR013234; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein (GlcNAc-PI synthesis protein) (Phosphatidylinositol-glycan biosynthesis class A protein) (PIG-A) Piga Mus musculus (Mouse) TR14509_c1_g1_i1 P97793 ALK_MOUSE 2.00E-11 GO:0005524; GO:0000187; GO:0005887; GO:0048666; GO:0004714; GO:0007169 ATP binding; activation of MAPK activity; integral to plasma membrane; neuron development; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR026830; IPR008985; IPR011009; IPR002172; IPR000998; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR002011; ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) Alk Mus musculus (Mouse) TR14510_c2_g1_i1 Q5R7Q3 NIPA2_PONAB 8.00E-34 GO:0005769; GO:0016021; GO:0015095; GO:0005886 early endosome; integral to membrane; magnesium ion transmembrane transporter activity; plasma membrane IPR008521; Magnesium transporter NIPA2 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog) NIPA2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR14512_c1_g1_i1 Q0P4F7 ACSF2_DANRE 3.00E-27 GO:0005524; GO:0006631; GO:0016874; GO:0005739 ATP binding; fatty acid metabolic process; ligase activity; mitochondrion IPR025110; IPR020845; IPR000873; "Acyl-CoA synthetase family member 2, mitochondrial (EC 6.2.1.-)" acsf2 zgc:152887 Danio rerio (Zebrafish) (Brachydanio rerio) TR14515_c0_g2_i1 Q8K0U4 HS12A_MOUSE 2.00E-46 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR14518_c0_g1_i1 Q9ERL9 GCYA3_MOUSE 4.00E-90 GO:0005525; GO:0006182; GO:0005737; GO:0004383; GO:0020037; GO:0035556; GO:0030828; GO:0008217; GO:0060087; GO:0052565 GTP binding; cGMP biosynthetic process; cytoplasm; guanylate cyclase activity; heme binding; intracellular signal transduction; positive regulation of cGMP biosynthetic process; regulation of blood pressure; relaxation of vascular smooth muscle; response to defense-related host nitric oxide production IPR001054; IPR018297; IPR011645; IPR011644; IPR024096; Guanylate cyclase soluble subunit alpha-3 (GCS-alpha-3) (EC 4.6.1.2) (GCS-alpha-1) (Soluble guanylate cyclase large subunit) Gucy1a3 Gucy1a1 Mus musculus (Mouse) TR14518_c0_g2_i1 P18293 ANPRA_MOUSE 1.00E-43 GO:0005524; GO:0005525; GO:0042417; GO:0004383; GO:0016021; GO:0035556; GO:0016941; GO:0048662; GO:0017046; GO:0005886; GO:0030828; GO:0004672; GO:0007168; GO:0050880 ATP binding; GTP binding; dopamine metabolic process; guanylate cyclase activity; integral to membrane; intracellular signal transduction; natriuretic peptide receptor activity; negative regulation of smooth muscle cell proliferation; peptide hormone binding; plasma membrane; positive regulation of cGMP biosynthetic process; protein kinase activity; receptor guanylyl cyclase signaling pathway; regulation of blood vessel size IPR001054; IPR018297; IPR001828; IPR011009; IPR001170; IPR028082; IPR000719; IPR001245; Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) Npr1 Npra Mus musculus (Mouse) TR14521_c0_g1_i1 Q9NUV9 GIMA4_HUMAN 7.00E-19 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR14521_c1_g1_i1 O81025 P2A03_ARATH 1.00E-12 GO:0005525; GO:0030246 GTP binding; carbohydrate binding IPR006703; IPR027417; IPR025886; Putative protein PHLOEM PROTEIN 2-LIKE A3 (AtPP2-A3) PP2A3 At2g26820 F12C20.14 Arabidopsis thaliana (Mouse-ear cress) TR14522_c0_g1_i1 P50416 CPT1A_HUMAN 7.00E-26 GO:0004095; GO:0009437; GO:0006853; GO:0042755; GO:0006635; GO:0006006; GO:0031307; GO:0001676; GO:0005743; GO:0032000; GO:0051260; GO:0050796; GO:0042493; GO:0014070; GO:0006641 carnitine O-palmitoyltransferase activity; carnitine metabolic process; carnitine shuttle; eating behavior; fatty acid beta-oxidation; glucose metabolic process; integral to mitochondrial outer membrane; long-chain fatty acid metabolic process; mitochondrial inner membrane; positive regulation of fatty acid beta-oxidation; protein homooligomerization; regulation of insulin secretion; response to drug; response to organic cyclic compound; triglyceride metabolic process IPR000542; Lipid metabolism; fatty acid beta-oxidation. "Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A)" CPT1A CPT1 Homo sapiens (Human) TR14524_c0_g1_i1 O14804 TAAR5_HUMAN 3.00E-12 GO:0005887; GO:0007268; GO:1990081 integral to plasma membrane; synaptic transmission; trimethylamine receptor activity IPR000276; IPR017452; IPR009132; Trace amine-associated receptor 5 (TaR-5) (Trace amine receptor 5) (hTaar5) (Putative neurotransmitter receptor) TAAR5 PNR Homo sapiens (Human) TR14524_c0_g2_i1 O14804 TAAR5_HUMAN 3.00E-12 GO:0005887; GO:0007268; GO:1990081 integral to plasma membrane; synaptic transmission; trimethylamine receptor activity IPR000276; IPR017452; IPR009132; Trace amine-associated receptor 5 (TaR-5) (Trace amine receptor 5) (hTaar5) (Putative neurotransmitter receptor) TAAR5 PNR Homo sapiens (Human) TR14531_c0_g1_i1 Q9UBQ7 GRHPR_HUMAN 2.00E-28 GO:0051287; GO:0070402; GO:0034641; GO:0007588; GO:0008465; GO:0046487; GO:0030267; GO:0016618; GO:0005782; GO:0042803; GO:0051259 NAD binding; NADPH binding; cellular nitrogen compound metabolic process; excretion; glycerate dehydrogenase activity; glyoxylate metabolic process; glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; peroxisomal matrix; protein homodimerization activity; protein oligomerization IPR006139; IPR006140; IPR016040; Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81) GRHPR GLXR MSTP035 Homo sapiens (Human) TR14537_c0_g1_i1 Q96RW7 HMCN1_HUMAN 4.00E-63 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR14540_c0_g1_i1 Q5S007 LRRK2_HUMAN 2.00E-06 GO:0005524; GO:0005525; GO:0034211; GO:0005096; GO:0003924; GO:0004708; GO:0000186; GO:0006914; GO:0032839; GO:0008340; GO:0035640; GO:0032473; GO:0048312; GO:0045121; GO:0034260; GO:2000173; GO:0061002; GO:0007406; GO:0014043; GO:0007528; GO:0070997; GO:0043025; GO:0018105; GO:0018107; GO:0005886; GO:0010508; GO:0060161; GO:0043068; GO:0032436; GO:0031398; GO:0046777; GO:0035564; GO:0040012; GO:0042391; GO:0006979; GO:0007264; GO:0008021; GO:0022028; GO:0005802; GO:0015631 Itself; Q9UKV8; P31749; Q8N6T3-2; Q62848; Q14155; Q16543; P60953; P30275; P53355; O00429; O00429-3; O14640-2; O14641; Q92997; Q13158; P11142; O75581; Q38SD2; P46734; P52564; O14733; P10636-8; P02687; P26038; Q13469; O60260; P30048; P61020; P61021; Q63481; P63000; Q99962; P37840; Q58A65; P31946; P62258; P61981; Q04917; P27348; P63104 ATP binding; GTP binding; GTP-dependent protein kinase activity; GTPase activator activity; GTPase activity; MAP kinase kinase activity; activation of MAPKK activity; autophagy; dendrite cytoplasm; determination of adult lifespan; exploration behavior; external side of mitochondrial outer membrane; intracellular distribution of mitochondria; membrane raft; negative regulation of GTPase activity; negative regulation of branching morphogenesis of a nerve; negative regulation of dendritic spine morphogenesis; negative regulation of neuroblast proliferation; negative regulation of neuron maturation; neuromuscular junction development; neuron death; neuronal cell body; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; plasma membrane; positive regulation of autophagy; positive regulation of dopamine receptor signaling pathway; positive regulation of programmed cell death; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; protein autophosphorylation; regulation of kidney size; regulation of locomotion; regulation of membrane potential; response to oxidative stress; small GTPase mediated signal transduction; synaptic vesicle; tangential migration from the subventricular zone to the olfactory bulb; trans-Golgi network; tubulin binding IPR020683; IPR011989; IPR016024; IPR011009; IPR001611; IPR025875; IPR003591; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR008271; IPR005225; IPR001806; IPR015943; IPR001680; IPR017986; Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin) LRRK2 PARK8 Homo sapiens (Human) TR14540_c2_g1_i1 A2AAJ9 OBSCN_MOUSE 3.00E-06 GO:0005524; GO:0031430; GO:0005089; GO:0030154; GO:0007275; GO:0018108; GO:0005543; GO:0004674; GO:0004713; GO:0035023 ATP binding; M band; Rho guanyl-nucleotide exchange factor activity; cell differentiation; multicellular organismal development; peptidyl-tyrosine phosphorylation; phospholipid binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of Rho protein signal transduction IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000048; IPR011009; IPR011993; IPR001849; IPR000719; IPR017441; IPR002290; IPR008271; IPR001452; IPR008266; Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Obscn Gm878 Mus musculus (Mouse) TR14552_c1_g1_i1 P42893 ECE1_RAT 7.00E-23 GO:0006915; GO:0005769; GO:0009897; GO:0016021; GO:0046872; GO:0004222; GO:0045745; GO:0030819; GO:0010613; GO:0001921; GO:0042803; GO:0016485; GO:0006508; GO:0070372; GO:0008217; GO:0042312; GO:0046686; GO:0042493; GO:0001666; GO:0035994; GO:0030141 apoptotic process; early endosome; external side of plasma membrane; integral to membrane; metal ion binding; metalloendopeptidase activity; positive regulation of G-protein coupled receptor protein signaling pathway; positive regulation of cAMP biosynthetic process; positive regulation of cardiac muscle hypertrophy; positive regulation of receptor recycling; protein homodimerization activity; protein processing; proteolysis; regulation of ERK1 and ERK2 cascade; regulation of blood pressure; regulation of vasodilation; response to cadmium ion; response to drug; response to hypoxia; response to muscle stretch; secretory granule IPR024079; IPR000718; IPR018497; IPR008753; Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) Ece1 Rattus norvegicus (Rat) TR14556_c0_g1_i1 P42345 MTOR_HUMAN 3.00E-37 GO:0005524; GO:0038095; GO:0000139; GO:0016605; GO:0001030; GO:0001031; GO:0001032; GO:0031295; GO:0001156; GO:0031929; GO:0031931; GO:0031932; GO:0016049; GO:0071456; GO:0031669; GO:0008144; GO:0012505; GO:0005789; GO:0007173; GO:0008543; GO:0007281; GO:0045087; GO:0008286; GO:0005765; GO:0070438; GO:0005741; GO:0051534; GO:0010507; GO:0045792; GO:0016242; GO:0048011; GO:0018105; GO:0018107; GO:0005942; GO:0048015; GO:0030838; GO:0001938; GO:0010592; GO:0046889; GO:0010831; GO:0050731; GO:0051897; GO:0001934; GO:0051496; GO:0045945; GO:0045727; GO:0046777; GO:0030163; GO:0004674; GO:0032314; GO:0032956; GO:0043610; GO:0031998; GO:0005979; GO:0045859; GO:0032095; GO:0043200; GO:0007584; GO:0043022; GO:0031529 Q8TB45; Q13541; Q9BVC4; Q8TCU6; Q6R327; Q8N122; Q96EB6; Q8NHX9 ATP binding; Fc-epsilon receptor signaling pathway; Golgi membrane; PML body; RNA polymerase III type 1 promoter DNA binding; RNA polymerase III type 2 promoter DNA binding; RNA polymerase III type 3 promoter DNA binding; T cell costimulation; TFIIIC-class transcription factor binding; TOR signaling cascade; TORC1 complex; TORC2 complex; cell growth; cellular response to hypoxia; cellular response to nutrient levels; drug binding; endomembrane system; endoplasmic reticulum membrane; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; germ cell development; innate immune response; insulin receptor signaling pathway; lysosomal membrane; mTOR-FKBP12-rapamycin complex; mitochondrial outer membrane; negative regulation of NFAT protein import into nucleus; negative regulation of autophagy; negative regulation of cell size; negative regulation of macroautophagy; neurotrophin TRK receptor signaling pathway; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphatidylinositol 3-kinase complex; phosphatidylinositol-mediated signaling; positive regulation of actin filament polymerization; positive regulation of endothelial cell proliferation; positive regulation of lamellipodium assembly; positive regulation of lipid biosynthetic process; positive regulation of myotube differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; positive regulation of transcription from RNA polymerase III promoter; positive regulation of translation; protein autophosphorylation; protein catabolic process; protein serine/threonine kinase activity; regulation of Rac GTPase activity; regulation of actin cytoskeleton organization; regulation of carbohydrate utilization; regulation of fatty acid beta-oxidation; regulation of glycogen biosynthetic process; regulation of protein kinase activity; regulation of response to food; response to amino acid stimulus; response to nutrient; ribosome binding; ruffle organization IPR011989; IPR016024; IPR024585; IPR003152; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR009076; IPR026683; IPR011990; Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 Homo sapiens (Human) TR14556_c1_g1_i1 P32600 TOR2_YEAST 4.00E-17 GO:0004430; GO:0005524; GO:0031929; GO:0031931; GO:0031932; GO:0030037; GO:0008144; GO:0030950; GO:0031234; GO:0000329; GO:0010507; GO:2001108; GO:0035025; GO:0045807; GO:0004674; GO:0051726; GO:0001558; GO:0042254 Q08236; Q04749; P47041; P41318; Q04372; P40061 1-phosphatidylinositol 4-kinase activity; ATP binding; TOR signaling cascade; TORC1 complex; TORC2 complex; actin filament reorganization involved in cell cycle; drug binding; establishment or maintenance of actin cytoskeleton polarity; extrinsic to internal side of plasma membrane; fungal-type vacuole membrane; negative regulation of autophagy; positive regulation of Rho guanyl-nucleotide exchange factor activity; positive regulation of Rho protein signal transduction; positive regulation of endocytosis; protein serine/threonine kinase activity; regulation of cell cycle; regulation of cell growth; ribosome biogenesis IPR011989; IPR016024; IPR024585; IPR003152; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR009076; IPR026683; Serine/threonine-protein kinase TOR2 (EC 2.7.1.67) (EC 2.7.11.1) (Dominant rapamycin resistance protein 2) (Phosphatidylinositol 4-kinase TOR2) (PI4-kinase TOR2) (PI4K TOR2) (PtdIns-4-kinase TOR2) (Target of rapamycin kinase 2) (Temperature-sensitive CSG2 suppressor protein 14) TOR2 DRR2 TSC14 YKL203C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR14558_c0_g1_i1 P0CC03 ST6B1_MOUSE 1.00E-07 GO:0005737; GO:0008146 cytoplasm; sulfotransferase activity IPR027417; IPR000863; Sulfotransferase 6B1 (ST6B1) (Thyroxine sulfotransferase) (EC 2.8.2.n2) Sult6b1 Mus musculus (Mouse) TR1456_c1_g1_i1 Q6AZW8 ZN660_HUMAN 2.00E-24 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 660 ZNF660 Homo sapiens (Human) TR14560_c1_g1_i1 P30974 TLR1_DROME 1.00E-09 GO:0004950; GO:0070098; GO:0006935; GO:0005887; GO:0004995 chemokine receptor activity; chemokine-mediated signaling pathway; chemotaxis; integral to plasma membrane; tachykinin receptor activity IPR000355; IPR000276; IPR017452; IPR001681; Tachykinin-like peptides receptor 86C (NKD) Takr86C NKD CG6515 Drosophila melanogaster (Fruit fly) TR14563_c1_g1_i2 P83425 HIP_MYTED 4.00E-08 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR14565_c0_g1_i1 Q810A1 ZNF18_MOUSE 1.00E-10 GO:0003677; GO:0046872; GO:0005634; GO:0000981 DNA binding; metal ion binding; nucleus; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR001909; IPR008916; IPR003309; IPR027764; IPR007087; IPR015880; IPR013087; Zinc finger protein 18 (Zinc finger protein 535) (Zinc finger protein with KRAB and SCAN domains 6) Znf18 Zfp535 Zkscan6 Mus musculus (Mouse) TR14567_c4_g1_i1 P33450 FAT_DROME 2.00E-15 GO:0005509; GO:0016339; GO:0050839; GO:0030054; GO:0000904; GO:0008283; GO:0045317; GO:0048105; GO:0045198; GO:0001737; GO:0035329; GO:0007156; GO:0007446; GO:0005887; GO:0090176; GO:0030178; GO:0008285; GO:0045571; GO:0016318; GO:0018149; GO:0004872; GO:0035159 "calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; cell junction; cell morphogenesis involved in differentiation; cell proliferation; equator specification; establishment of body hair planar orientation; establishment of epithelial cell apical/basal polarity; establishment of imaginal disc-derived wing hair orientation; hippo signaling cascade; homophilic cell adhesion; imaginal disc growth; integral to plasma membrane; microtubule cytoskeleton organization involved in establishment of planar polarity; negative regulation of Wnt receptor signaling pathway; negative regulation of cell proliferation; negative regulation of imaginal disc growth; ommatidial rotation; peptide cross-linking; receptor activity; regulation of tube length, open tracheal system" IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR013032; IPR001791; Cadherin-related tumor suppressor (Protein fat) ft CG3352 Drosophila melanogaster (Fruit fly) TR14576_c0_g1_i1 E3W9C4 C71A1_ZINZE 1.00E-18 GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705 "heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Alpha-humulene 10-hydroxylase (EC 1.14.13.150) CYP71BA1 Zingiber zerumbet (Shampoo ginger) (Amomum zerumbet) TR14576_c0_g2_i1 Q9Y6A2 CP46A_HUMAN 4.00E-41 GO:0006699; GO:0033781; GO:0006707; GO:0005789; GO:0020037; GO:0016021; GO:0005506; GO:0007399; GO:0008395; GO:0006805 bile acid biosynthetic process; cholesterol 24-hydroxylase activity; cholesterol catabolic process; endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding; nervous system development; steroid hydroxylase activity; xenobiotic metabolic process IPR001128; IPR017972; IPR002401; Cholesterol 24-hydroxylase (CH24H) (EC 1.14.13.98) (Cytochrome P450 46A1) CYP46A1 CYP46 Homo sapiens (Human) TR14576_c1_g1_i1 Q9WVK8 CP46A_MOUSE 9.00E-29 GO:0033781; GO:0006707; GO:0005789; GO:0020037; GO:0016021; GO:0005506; GO:0006805 cholesterol 24-hydroxylase activity; cholesterol catabolic process; endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding; xenobiotic metabolic process IPR001128; IPR017972; IPR002401; Cholesterol 24-hydroxylase (CH24H) (EC 1.14.13.98) (Cytochrome P450 46A1) Cyp46a1 Cyp46 Mus musculus (Mouse) TR14579_c0_g1_i1 Q14590 ZN235_HUMAN 4.00E-50 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) TR14579_c1_g1_i1 Q15697 ZN174_HUMAN 2.00E-22 GO:0015629; GO:0005737; GO:0046872; GO:0000122; GO:0005634; GO:0000981; GO:0044212 actin cytoskeleton; cytoplasm; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding RNA polymerase II transcription factor activity; transcription regulatory region DNA binding IPR027775; IPR008916; IPR003309; IPR027778; IPR007087; IPR015880; IPR013087; Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8) ZNF174 ZSCAN8 Homo sapiens (Human) TR14581_c0_g1_i2 Q95JH7 AK1C1_MACFA 2.00E-23 GO:0047006; GO:0047042; GO:0032052; GO:0008206; GO:0005829; GO:0007586; GO:0047718; GO:0051260; GO:0047115 "17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity; androsterone dehydrogenase (B-specific) activity; bile acid binding; bile acid metabolic process; cytosol; digestion; indanol dehydrogenase activity; protein homooligomerization; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity" IPR001395; IPR018170; IPR020471; IPR023210; Aldo-keto reductase family 1 member C1 homolog (EC 1.-.-.-) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Dihydrodiol dehydrogenase 1) (DD-1) (DD1) (Indanol dehydrogenase) (EC 1.1.1.112) AKR1C1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR14589_c0_g1_i1 Q9Z205 RFXK_MOUSE 9.00E-06 GO:0003677; GO:0007265; GO:0005737; GO:0042826; GO:0005634; GO:0045944; GO:0006351 "DNA binding; Ras protein signal transduction; cytoplasm; histone deacetylase binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR002110; IPR020683; IPR017362; DNA-binding protein RFXANK (Ankyrin repeat-containing adapter protein Tvl-1) (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein) Rfxank Rfxb Tvl1 Mus musculus (Mouse) TR14589_c0_g2_i1 Q6P9Z4 FEM1A_DANRE 3.00E-18 GO:0005737; GO:0051438; GO:0004842 cytoplasm; regulation of ubiquitin-protein ligase activity; ubiquitin-protein ligase activity IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog A (FEM1a) (FEM1-alpha) fem1a zgc:63483 Danio rerio (Zebrafish) (Brachydanio rerio) TR14589_c1_g1_i1 Q68DC2 ANKS6_HUMAN 7.00E-09 GO:0005737 cytoplasm IPR002110; IPR020683; IPR001660; IPR013761; IPR021129; Ankyrin repeat and SAM domain-containing protein 6 (Ankyrin repeat domain-containing protein 14) (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6) ANKS6 ANKRD14 PKDR1 SAMD6 Homo sapiens (Human) TR14590_c0_g1_i1 P52209 6PGD_HUMAN 4.00E-37 GO:0019521; GO:0050661; GO:0005829; GO:0019322; GO:0009051; GO:0004616 O95777 "D-gluconate metabolic process; NADP binding; cytosol; pentose biosynthetic process; pentose-phosphate shunt, oxidative branch; phosphogluconate dehydrogenase (decarboxylating) activity" IPR008927; IPR006114; IPR006113; IPR006115; IPR006184; IPR013328; IPR012284; IPR016040; Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. "6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)" PGD PGDH Homo sapiens (Human) TR14595_c0_g1_i1 Q3YK19 FANCJ_CHICK 3.00E-61 GO:0051539; GO:0005524; GO:0004003; GO:0003677; GO:0006281; GO:0046872; GO:0005654 "4 iron, 4 sulfur cluster binding; ATP binding; ATP-dependent DNA helicase activity; DNA binding; DNA repair; metal ion binding; nucleoplasm" IPR006555; IPR010614; IPR013020; IPR014013; IPR006554; IPR027417; Fanconi anemia group J protein homolog (Protein FACJ) (EC 3.6.4.13) (ATP-dependent RNA helicase BRIP1) BRIP1 FANCJ Gallus gallus (Chicken) TR1460_c0_g1_i1 Q08890 IDS_MOUSE 4.00E-11 GO:0004423; GO:0005764; GO:0046872; GO:0008484 iduronate-2-sulfatase activity; lysosome; metal ion binding; sulfuric ester hydrolase activity IPR017849; IPR017850; IPR000917; IPR024607; Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) Ids Mus musculus (Mouse) TR14612_c0_g1_i1 Q8QGW7 LITAF_CHICK 2.00E-13 GO:0005125; GO:0005737; GO:0006355; GO:0006351 "cytokine activity; cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) TR14617_c0_g1_i1 Q8BN82 S17A5_MOUSE 4.00E-36 GO:0006865; GO:0030054; GO:0016023; GO:0016021; GO:0005765; GO:0005886; GO:0015136; GO:0015739; GO:0015293; GO:0030672 amino acid transport; cell junction; cytoplasmic membrane-bounded vesicle; integral to membrane; lysosomal membrane; plasma membrane; sialic acid transmembrane transporter activity; sialic acid transport; symporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) Slc17a5 Mus musculus (Mouse) TR14617_c0_g2_i1 Q03567 YLD2_CAEEL 4.00E-41 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR011701; IPR020846; IPR016196; Uncharacterized transporter C38C10.2 C38C10.2 Caenorhabditis elegans TR14617_c1_g1_i1 Q9SDI4 PHT41_ORYSJ 1.00E-14 GO:0031969; GO:0016021; GO:0006811; GO:0055085 chloroplast membrane; integral to membrane; ion transport; transmembrane transport IPR011701; IPR020846; IPR016196; "Probable anion transporter 1, chloroplastic (Phosphate transporter 4;1)" PHT4;1 Os01g0279700 LOC_Os01g17240 OsJ_01311 OSJNBa0036E02.3 P0003H10.9 Oryza sativa subsp. japonica (Rice) TR14619_c2_g1_i1 Q11082 YT66_CAEEL 2.00E-09 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR000276; IPR017452; Probable G-protein coupled receptor B0563.6 B0563.6 Caenorhabditis elegans TR14622_c0_g1_i1 Q62623 CDC20_RAT 4.00E-12 GO:0051488; GO:0005680; GO:0031145; GO:0051301; GO:0005813; GO:0007067; GO:0048471; GO:0008284; GO:0090129; GO:0031915; GO:0043234; GO:0016567; GO:0050773; GO:0040020; GO:0000922 Q9UBN7 activation of anaphase-promoting complex activity; anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; centrosome; mitosis; perinuclear region of cytoplasm; positive regulation of cell proliferation; positive regulation of synapse maturation; positive regulation of synaptic plasticity; protein complex; protein ubiquitination; regulation of dendrite development; regulation of meiosis; spindle pole IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. Cell division cycle protein 20 homolog (p55CDC) Cdc20 Rattus norvegicus (Rat) TR14627_c0_g1_i1 P30304 MPIP1_HUMAN 3.00E-26 GO:0006260; GO:0000082; GO:0000086; GO:0051301; GO:0008283; GO:0034644; GO:0005829; GO:0007067; GO:0005654; GO:0035335; GO:0004725; GO:0000079 P04049; P31946; P63104 DNA replication; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; cell division; cell proliferation; cellular response to UV; cytosol; mitosis; nucleoplasm; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; regulation of cyclin-dependent protein serine/threonine kinase activity IPR000751; IPR001763; M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) CDC25A Homo sapiens (Human) TR14628_c2_g1_i1 Q9UL68 MYT1L_HUMAN 4.00E-17 GO:0003677; GO:0030154; GO:0007399; GO:0005634; GO:0003700; GO:0006351; GO:0008270 "DNA binding; cell differentiation; nervous system development; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR013681; IPR002515; Myelin transcription factor 1-like protein (MyT1-L) (MyT1L) MYT1L KIAA1106 Homo sapiens (Human) TR14641_c0_g1_i1 Q8MKI5 CASP3_CANFA 3.00E-12 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Canis familiaris (Dog) (Canis lupus familiaris) TR14670_c1_g1_i1 Q96NL3 ZN599_HUMAN 3.00E-11 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 599 ZNF599 Homo sapiens (Human) TR14673_c2_g1_i1 Q55E58 PATS1_DICDI 1.00E-06 GO:0005524; GO:0005525; GO:0042641; GO:0000281; GO:0004721; GO:0006470; GO:0004674; GO:0007264 ATP binding; GTP binding; actomyosin; mitotic cytokinesis; phosphoprotein phosphatase activity; protein dephosphorylation; protein serine/threonine kinase activity; small GTPase mediated signal transduction IPR011009; IPR001611; IPR013684; IPR010569; IPR017906; IPR027417; IPR000719; IPR011047; IPR020859; IPR001245; IPR008271; IPR005225; IPR001806; IPR015943; IPR001680; IPR017986; Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) TR14677_c2_g1_i1 A3KQS4 FA63A_DANRE 8.00E-106 IPR007518; Protein FAM63A fam63a si:ch211-210h11.5 Danio rerio (Zebrafish) (Brachydanio rerio) TR14679_c0_g1_i1 Q9Y2D4 EXC6B_HUMAN 4.00E-37 GO:0000145; GO:0015031; GO:0006904 exocyst; protein transport; vesicle docking involved in exocytosis IPR007225; Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2) EXOC6B KIAA0919 SEC15B SEC15L2 Homo sapiens (Human) TR14679_c0_g4_i1 Q9Y2D4 EXC6B_HUMAN 4.00E-37 GO:0000145; GO:0015031; GO:0006904 exocyst; protein transport; vesicle docking involved in exocytosis IPR007225; Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2) EXOC6B KIAA0919 SEC15B SEC15L2 Homo sapiens (Human) TR14693_c1_g2_i1 P25867 UBCD1_DROME 9.00E-13 GO:0005524; GO:0051276; GO:0001751; GO:0008054; GO:0048132; GO:0030718; GO:0007140; GO:0005875; GO:0007067; GO:0016322; GO:0045676; GO:0031647; GO:0007286; GO:0004842 ATP binding; chromosome organization; compound eye photoreceptor cell differentiation; cyclin catabolic process; female germ-line stem cell division; germ-line stem cell maintenance; male meiosis; microtubule associated complex; mitosis; neuron remodeling; regulation of R7 cell differentiation; regulation of protein stability; spermatid development; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2-17 kDa (EC 6.3.2.19) (Protein effete) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) eff UbcD1 CG7425 Drosophila melanogaster (Fruit fly) TR14699_c0_g1_i1 A8MXE2 YI036_HUMAN 1.00E-22 GO:0000139; GO:0008378; GO:0016021; GO:0006486 Golgi membrane; galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; "Putative UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase LOC402377 (EC 2.4.1.-)" Homo sapiens (Human) TR14700_c1_g2_i1 Q0IH86 SLX1_XENLA 1.00E-68 GO:0017108; GO:0006310; GO:0006281; GO:0033557; GO:0046872 5'-flap endonuclease activity; DNA recombination; DNA repair; Slx1-Slx4 complex; metal ion binding IPR000305; IPR027520; Structure-specific endonuclease subunit slx1 (EC 3.6.1.-) (GIY-YIG domain-containing protein 1) slx1a giyd1 slx1 Xenopus laevis (African clawed frog) TR14706_c2_g1_i1 Q9Z2D5 NPY2R_CAVPO 1.00E-07 GO:0016021; GO:0004983; GO:0005886 integral to membrane; neuropeptide Y receptor activity; plasma membrane IPR000276; IPR017452; IPR001358; IPR000611; Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor) (Y2 receptor) NPY2R Cavia porcellus (Guinea pig) TR14707_c0_g1_i1 P82596 PLC_HALLA 7.00E-73 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR1471_c0_g1_i1 Q9EQX9 UBE2N_RAT 3.00E-83 GO:0005524; GO:0006281; GO:0035370; GO:0070534; GO:0000151; GO:0006511; GO:0004842 ATP binding; DNA repair; UBC13-UEV1A complex; protein K63-linked ubiquitination; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 N (EC 6.3.2.19) (Bendless-like ubiquitin-conjugating enzyme) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N) Ube2n Rattus norvegicus (Rat) TR14715_c0_g1_i1 Q2ES47 IVBI4_DABRR 1.00E-07 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Protease inhibitor 4 (Kunitz protease inhibitor 4) (Kunitz protease inhibitor IV) Daboia russelii (Russel's viper) (Vipera russelii) TR14740_c0_g1_i1 O09160 FUT1_MOUSE 2.00E-24 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" Fut1 Mus musculus (Mouse) TR14746_c0_g1_i1 Q09460 PDFR1_CAEEL 5.00E-07 GO:0007189; GO:0004948; GO:0006874; GO:0016021; GO:0005886; GO:0045762 adenylate cyclase-activating G-protein coupled receptor signaling pathway; calcitonin receptor activity; cellular calcium ion homeostasis; integral to membrane; plasma membrane; positive regulation of adenylate cyclase activity IPR017981; IPR001879; IPR000832; IPR017983; Calcitonin receptor-like protein 1 (Pigment dispersing factor neuropeptide receptor homolog 1) pdfr-1 seb-1 C13B9.4 Caenorhabditis elegans TR14747_c1_g1_i1 Q9P2P6 STAR9_HUMAN 2.00E-08 GO:0005524; GO:0005814; GO:0008289; GO:0008017; GO:0003777; GO:0007018; GO:0005634; GO:0051225 ATP binding; centriole; lipid binding; microtubule binding; microtubule motor activity; microtubule-based movement; nucleus; spindle assembly IPR000253; IPR019821; IPR001752; IPR027417; IPR008984; IPR023393; IPR002913; StAR-related lipid transfer protein 9 (START domain-containing protein 9) (StARD9) STARD9 KIAA1300 Homo sapiens (Human) TR14755_c1_g1_i1 Q967D7 TUTL_DROME 5.00E-14 GO:0016199; GO:0007414; GO:0070593; GO:0007629; GO:0016021; GO:0030537; GO:0046331; GO:0048814; GO:0008039 Q9VQW7 axon midline choice point recognition; axonal defasciculation; dendrite self-avoidance; flight behavior; integral to membrane; larval behavior; lateral inhibition; regulation of dendrite morphogenesis; synaptic target recognition IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Protein turtle tutl CG15427 Drosophila melanogaster (Fruit fly) TR14755_c2_g1_i1 Q05BQ1 TUTLA_MOUSE 1.00E-14 GO:0030054; GO:0030425; GO:0016358; GO:0016021; GO:0005886; GO:0045202 cell junction; dendrite; dendrite development; integral to membrane; plasma membrane; synapse IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Protein turtle homolog A (Dendrite arborization and synapse maturation protein 1) (Immunoglobulin superfamily member 9A) (IgSF9A) Igsf9 Dasm1 Igsf9a Nrt1 Mus musculus (Mouse) TR14762_c1_g1_i1 P86854 PLCL_MYTGA 8.00E-26 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR14762_c1_g2_i1 P0DJC9 LECAB_BOTAS 9.00E-07 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR016187; Snaclec aspercetin subunit beta (Fragment) Bothrops asper (Terciopelo) TR14780_c0_g1_i1 Q8NF86 PRS33_HUMAN 1.00E-18 GO:0005615; GO:0006508; GO:0004252 extracellular space; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Serine protease 33 (EC 3.4.21.-) (Serine protease EOS) PRSS33 Homo sapiens (Human) TR14788_c0_g1_i1 P49916 DNLI3_HUMAN 2.00E-31 GO:0005524; GO:0003677; GO:0003910; GO:0051103; GO:0006284; GO:0051301; GO:0005694; GO:0006303; GO:0006273; GO:0043504; GO:0045910; GO:0005654; GO:0006289; GO:0007131; GO:0007283; GO:0000795; GO:0008270 ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligation involved in DNA repair; base-excision repair; cell division; chromosome; double-strand break repair via nonhomologous end joining; lagging strand elongation; mitochondrial DNA repair; negative regulation of DNA recombination; nucleoplasm; nucleotide-excision repair; reciprocal meiotic recombination; spermatogenesis; synaptonemal complex; zinc ion binding IPR001357; IPR000977; IPR012309; IPR012310; IPR016059; IPR012308; IPR012340; IPR001510; DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) LIG3 Homo sapiens (Human) TR14797_c0_g1_i1 Q08BY5 JMJD4_DANRE 2.00E-08 IPR003347; JmjC domain-containing protein 4 (Jumonji domain-containing protein 4) jmjd4 zgc:153974 Danio rerio (Zebrafish) (Brachydanio rerio) TR14799_c0_g1_i1 Q7PKQ5 ACTN_ANOGA 5.00E-81 GO:0005509 calcium ion binding IPR001589; IPR001715; IPR011992; IPR014837; IPR018247; IPR002048; IPR018159; IPR002017; "Alpha-actinin, sarcomeric (F-actin cross-linking protein)" Actn AGAP001497 Anopheles gambiae (African malaria mosquito) TR14799_c5_g1_i1 P07751 SPTN1_CHICK 7.00E-19 GO:0051693; GO:0005509; GO:0005938; GO:0005856 actin filament capping; calcium ion binding; cell cortex; cytoskeleton IPR011992; IPR014837; IPR018247; IPR002048; IPR001452; IPR018159; IPR013315; IPR002017; "Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain)" SPTAN1 SPTA2 Gallus gallus (Chicken) TR14800_c0_g1_i1 Q09596 GST5_CAEEL 1.00E-47 GO:0004364 glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Probable glutathione S-transferase 5 (EC 2.5.1.18) (GST class-sigma) gst-5 R03D7.6 Caenorhabditis elegans TR14803_c0_g1_i1 P15848 ARSB_HUMAN 3.00E-96 GO:0005794; GO:0003943; GO:0004065; GO:0006914; GO:0005975; GO:0007417; GO:0030207; GO:0005788; GO:0006687; GO:0043202; GO:0007041; GO:0007040; GO:0046872; GO:0005739; GO:0043687; GO:0043627; GO:0051597; GO:0007584; GO:0009268; GO:0005791 Golgi apparatus; N-acetylgalactosamine-4-sulfatase activity; arylsulfatase activity; autophagy; carbohydrate metabolic process; central nervous system development; chondroitin sulfate catabolic process; endoplasmic reticulum lumen; glycosphingolipid metabolic process; lysosomal lumen; lysosomal transport; lysosome organization; metal ion binding; mitochondrion; post-translational protein modification; response to estrogen stimulus; response to methylmercury; response to nutrient; response to pH; rough endoplasmic reticulum IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) ARSB Homo sapiens (Human) TR14803_c1_g1_i1 Q21376 SULF1_CAEEL 1.00E-05 GO:0005795; GO:0009986; GO:0005783; GO:0017095; GO:0015015; GO:0046872; GO:0008484 "Golgi stack; cell surface; endoplasmic reticulum; heparan sulfate 6-O-sulfotransferase activity; heparan sulfate proteoglycan biosynthetic process, enzymatic modification; metal ion binding; sulfuric ester hydrolase activity" IPR017849; IPR017850; IPR000917; IPR024607; Putative extracellular sulfatase Sulf-1 homolog (CeSulf-1) (EC 3.1.6.-) sul-1 K09C4.8 Caenorhabditis elegans TR14803_c1_g1_i2 P50428 ARSA_MOUSE 4.00E-28 GO:0007339; GO:0005509; GO:0004098; GO:0016021; GO:0005764; GO:0005886; GO:0008484 binding of sperm to zona pellucida; calcium ion binding; cerebroside-sulfatase activity; integral to membrane; lysosome; plasma membrane; sulfuric ester hydrolase activity IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase A (ASA) (EC 3.1.6.8) (Cerebroside-sulfatase) Arsa As2 Mus musculus (Mouse) TR14808_c0_g1_i1 P16641 KTRC_SCHMA 4.00E-17 GO:0005524; GO:0046872; GO:0016491; GO:0050324 ATP binding; metal ion binding; oxidoreductase activity; taurocyamine kinase activity IPR022415; IPR022414; IPR022413; IPR014746; Taurocyamine kinase (EC 2.7.3.4) (ATP:guanidino kinase Smc74) (ATP:guanidino phosphotransferase) (SmGK) Smp_194770 Schistosoma mansoni (Blood fluke) TR14808_c1_g1_i1 P11009 KCRS_CHICK 2.00E-40 GO:0005524; GO:0004111; GO:0005743 ATP binding; creatine kinase activity; mitochondrial inner membrane IPR022415; IPR022414; IPR022413; IPR014746; "Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK)" CKMT2 Gallus gallus (Chicken) TR14810_c2_g1_i1 Q9MYM7 B3GT1_PONPY 2.00E-07 GO:0000139; GO:0008378; GO:0016021; GO:0006486 Golgi membrane; galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) TR14815_c0_g1_i1 Q8R4C0 CAN5_RAT 6.00E-24 GO:0004198; GO:0009986; GO:0060014; GO:0005622; GO:0001553; GO:0001541; GO:0006508 calcium-dependent cysteine-type endopeptidase activity; cell surface; granulosa cell differentiation; intracellular; luteinization; ovarian follicle development; proteolysis IPR000008; IPR022684; IPR022682; IPR022683; IPR000169; IPR001300; Calpain-5 (EC 3.4.22.-) Capn5 Rattus norvegicus (Rat) TR14817_c0_g1_i1 Q6AZT2 SPAST_XENLA 6.00E-09 GO:0005524; GO:0043014; GO:0007409; GO:0048487; GO:0007049; GO:0051301; GO:0005813; GO:0016021; GO:0005874; GO:0008017; GO:0001578; GO:0051013; GO:0008568; GO:0005634; GO:0048471; GO:0031117; GO:0034214; GO:0051260 ATP binding; alpha-tubulin binding; axonogenesis; beta-tubulin binding; cell cycle; cell division; centrosome; integral to membrane; microtubule; microtubule binding; microtubule bundle formation; microtubule severing; microtubule-severing ATPase activity; nucleus; perinuclear region of cytoplasm; positive regulation of microtubule depolymerization; protein hexamerization; protein homooligomerization IPR003593; IPR003959; IPR003960; IPR007330; IPR027417; IPR017179; Spastin (EC 3.6.4.3) spast spg4 Xenopus laevis (African clawed frog) TR14830_c0_g1_i1 Q13263 TIF1B_HUMAN 6.00E-10 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR14837_c1_g1_i1 Q9USH8 GLU2B_SCHPO 7.00E-13 GO:0006491; GO:0005783; GO:0004573 N-glycan processing; endoplasmic reticulum; mannosyl-oligosaccharide glucosidase activity IPR026874; IPR002172; IPR009011; IPR028146; Glucosidase 2 subunit beta (Alpha-glucosidase 2 subunit beta) gtb1 gls2-beta SPCC825.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR14840_c1_g1_i1 Q91ZY8 TRIM9_RAT 2.00E-27 GO:0030054; GO:0005856; GO:0030425; GO:0035544; GO:0045955; GO:0043161; GO:0008021; GO:0016079; GO:0004842; GO:0008270 cell junction; cytoskeleton; dendrite; negative regulation of SNARE complex assembly; negative regulation of calcium ion-dependent exocytosis; proteasomal ubiquitin-dependent protein catabolic process; synaptic vesicle; synaptic vesicle exocytosis; ubiquitin-protein ligase activity; zinc ion binding IPR001870; IPR003649; IPR008985; IPR017903; IPR003961; IPR013783; IPR003877; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM9 (EC 6.3.2.-) (SNAP-25-interacting RING finger protein) (Tripartite motif-containing protein 9) Trim9 Spring Rattus norvegicus (Rat) TR14846_c0_g1_i1 Q5MCW4 ZN569_HUMAN 9.00E-29 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 569 ZNF569 Homo sapiens (Human) TR14867_c0_g1_i1 A4QNI8 ELAV4_XENTR 2.00E-67 GO:0003723; GO:0007275; GO:0000166; GO:0030529 RNA binding; multicellular organismal development; nucleotide binding; ribonucleoprotein complex IPR006548; IPR002343; IPR012677; IPR000504; ELAV-like protein 4 (Protein ElrD) elavl4 elrD Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR14911_c0_g1_i1 P74148 Y1388_SYNY3 6.00E-09 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein Sll1388 (USP Sll1388) sll1388 Synechocystis sp. (strain PCC 6803 / Kazusa) TR1492_c0_g1_i1 P40693 RLP7_YEAST 6.00E-28 GO:0000465; GO:0000463; GO:0005730; GO:0030687; GO:0019843 "exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleolus; preribosome, large subunit precursor; rRNA binding" IPR018038; IPR016082; Ribosome biogenesis protein RLP7 (Ribosomal protein L7-like) RLP7 RPL7 YNL002C N2014 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR1492_c0_g2_i1 O01802 RL7_CAEEL 6.00E-105 GO:0003723; GO:0005840 RNA binding; ribosome IPR018038; IPR016082; IPR012988; IPR005998; 60S ribosomal protein L7 rpl-7 F53G12.10 Caenorhabditis elegans TR14921_c0_g1_i1 Q6TMK4 POXA_DICDI 4.00E-19 GO:0005576; GO:0020037; GO:0042744; GO:0006955; GO:0004601 extracellular region; heme binding; hydrogen peroxide catabolic process; immune response; peroxidase activity IPR010255; IPR002007; IPR019791; Peroxinectin A (EC 1.11.1.7) poxA DDB_G0277275 Dictyostelium discoideum (Slime mold) TR14929_c0_g1_i1 P97479 MYO7A_MOUSE 2.00E-52 GO:0005524; GO:0030048; GO:0016324; GO:0060088; GO:0005516; GO:0005938; GO:0005829; GO:0050957; GO:0006886; GO:0005765; GO:0007040; GO:0042470; GO:0000146; GO:0016459; GO:0001845; GO:0032391; GO:0001917; GO:0001750; GO:0051904; GO:0048563; GO:0007605; GO:0032420; GO:0045202; GO:0007601 Q80T11 ATP binding; actin filament-based movement; apical plasma membrane; auditory receptor cell stereocilium organization; calmodulin binding; cell cortex; cytosol; equilibrioception; intracellular protein transport; lysosomal membrane; lysosome organization; melanosome; microfilament motor activity; myosin complex; phagolysosome assembly; photoreceptor connecting cilium; photoreceptor inner segment; photoreceptor outer segment; pigment granule transport; post-embryonic organ morphogenesis; sensory perception of sound; stereocilium; synapse; visual perception IPR019749; IPR014352; IPR019748; IPR000299; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; IPR001452; Unconventional myosin-VIIa Myo7a Myo7 Mus musculus (Mouse) TR14938_c0_g1_i1 P95607 CATA_RHOOP 5.00E-15 GO:0019439; GO:0018576; GO:0009712; GO:0008199 "aromatic compound catabolic process; catechol 1,2-dioxygenase activity; catechol-containing compound metabolic process; ferric iron binding" IPR007535; IPR012800; IPR000627; IPR015889; "Catechol 1,2-dioxygenase (EC 1.13.11.1) (1,2-CTD) (Fragment)" catA Rhodococcus opacus (Nocardia opaca) TR14948_c0_g2_i1 Q69ZJ7 RIC1_MOUSE 3.00E-46 GO:0016021 integral to membrane IPR011044; IPR009771; IPR015943; Protein RIC1 homolog Kiaa1432 Mus musculus (Mouse) TR14952_c2_g1_i1 Q91755 GRIK2_XENLA 1.00E-19 GO:0030054; GO:0005234; GO:0016021; GO:0004970; GO:0035235; GO:0045211 cell junction; extracellular-glutamate-gated ion channel activity; integral to membrane; ionotropic glutamate receptor activity; ionotropic glutamate receptor signaling pathway; postsynaptic membrane IPR001320; IPR001508; "Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6) (Fragment)" grik2 glur6 Xenopus laevis (African clawed frog) TR14953_c0_g1_i1 Q9CQF4 CF203_MOUSE 2.00E-06 GO:0005739 mitochondrion Uncharacterized protein C6orf203 homolog Mus musculus (Mouse) TR14955_c0_g1_i1 Q9XZC8 SEM2A_SCHGR 2.00E-17 GO:0030154; GO:0005576; GO:0016020; GO:0007399; GO:0004872 cell differentiation; extracellular region; membrane; nervous system development; receptor activity IPR007110; IPR013783; IPR003599; IPR016201; IPR001627; IPR027231; IPR015943; Semaphorin-2A (Sema-2A) (Sema II) SEMA-2A Schistocerca gregaria (Desert locust) TR14959_c1_g1_i1 P15619 SRYC_DROME 6.00E-12 GO:0003677; GO:0046872; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Serendipity locus protein H-1 (Protein pourquoi-pas) (Protein wings-down) wdn pqp sry h-1 Sry-c CG1454 Drosophila melanogaster (Fruit fly) TR14961_c0_g1_i1 Q8K3K9 GIMA4_RAT 4.00E-21 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) TR14966_c1_g1_i1 Q6PDK2 MLL2_MOUSE 4.00E-40 GO:0006342; GO:0051568; GO:0018024; GO:0001701; GO:0005634; GO:0001555; GO:0006351; GO:0008270 "chromatin silencing; histone H3-K4 methylation; histone-lysine N-methyltransferase activity; in utero embryonic development; nucleus; oocyte growth; transcription, DNA-dependent; zinc ion binding" IPR003889; IPR003888; IPR009071; IPR003616; IPR001214; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.43) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Kmt2d Mll2 Mll4 Mus musculus (Mouse) TR14978_c0_g1_i1 P70097 C560_CRIGR 1.00E-13 GO:0009055; GO:0020037; GO:0016021; GO:0046872; GO:0005749; GO:0000104; GO:0006099 electron carrier activity; heme binding; integral to membrane; metal ion binding; mitochondrial respiratory chain complex II; succinate dehydrogenase activity; tricarboxylic acid cycle IPR018495; IPR014314; IPR014361; IPR000701; Carbohydrate metabolism; tricarboxylic acid cycle. "Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Integral membrane protein CII-3) (QPs-1) (QPs1)" SDHC Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR14981_c1_g1_i1 Q6P3V7 GNN_RAT 2.00E-15 GO:0005737 cytoplasm IPR027417; IPR011990; Tetratricopeptide repeat protein GNN (TPR repeat protein GNN) (Grp94-neighboring nucleotidase) Gnn Rattus norvegicus (Rat) TR14984_c0_g2_i1 Q63HM2 PCX4_HUMAN 1.00E-10 GO:0016021 integral to membrane IPR007735; Pecanex-like protein 4 (Hepatitis C virus F protein-binding protein 2) (HCV F protein-binding protein 2) PCNXL4 C14orf135 FBP2 Homo sapiens (Human) TR14990_c0_g1_i1 O35460 ANGP1_RAT 1.00E-18 GO:0001525; GO:0030154; GO:0005615; GO:0072012; GO:0043066; GO:0031100; GO:0001541; GO:0051260; GO:0043627; GO:0001666; GO:0033552 angiogenesis; cell differentiation; extracellular space; glomerulus vasculature development; negative regulation of apoptotic process; organ regeneration; ovarian follicle development; protein homooligomerization; response to estrogen stimulus; response to hypoxia; response to vitamin B3 IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-1 (ANG-1) Angpt1 Rattus norvegicus (Rat) TR150_c0_g1_i1 P14381 YTX2_XENLA 3.00E-06 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR15000_c0_g2_i1 Q6AZJ9 RS21_XENLA 6.00E-34 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001931; IPR018279; 40S ribosomal protein S21 rps21 Xenopus laevis (African clawed frog) TR15005_c0_g1_i1 Q9UAS2 FABP1_FASGI 7.00E-08 GO:0008289; GO:0005215 lipid binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; Fatty acid-binding protein 1 FABP-1 Fasciola gigantica (Giant liver fluke) TR15009_c0_g1_i1 Q8K2Y7 RM47_MOUSE 2.00E-37 GO:0005761; GO:0005739; GO:0003735; GO:0006412 mitochondrial ribosome; mitochondrion; structural constituent of ribosome; translation IPR010729; "39S ribosomal protein L47, mitochondrial (L47mt) (MRP-L47)" Mrpl47 Mus musculus (Mouse) TR15012_c0_g1_i1 A1A4K8 U2AF1_BOVIN 2.00E-38 GO:0003723; GO:0008380; GO:0071013; GO:0006397; GO:0046872; GO:0016607; GO:0000166 RNA binding; RNA splicing; catalytic step 2 spliceosome; mRNA processing; metal ion binding; nuclear speck; nucleotide binding IPR012677; IPR000504; IPR009145; IPR000571; Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 snRNP auxiliary factor small subunit) U2AF1 Bos taurus (Bovine) TR15027_c1_g2_i2 Q8TDX7 NEK7_HUMAN 4.00E-170 GO:0005524; GO:0000910; GO:0005737; GO:0046872; GO:0005874; GO:0005815; GO:0005634; GO:0004674; GO:0007346; GO:0051225; GO:0000922 ATP binding; cytokinesis; cytoplasm; metal ion binding; microtubule; microtubule organizing center; nucleus; protein serine/threonine kinase activity; regulation of mitotic cell cycle; spindle assembly; spindle pole IPR011009; IPR000719; IPR017441; IPR001245; IPR002290; IPR008271; Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) NEK7 Homo sapiens (Human) TR15029_c0_g1_i1 Q62671 UBR5_RAT 1.00E-39 GO:0006281; GO:0003723; GO:0005737; GO:2000780; GO:1901315; GO:0005634; GO:0050847; GO:0042787; GO:0006974; GO:0004842; GO:0008270 DNA repair; RNA binding; cytoplasm; negative regulation of double-strand break repair; negative regulation of histone H2A K63-linked ubiquitination; nucleus; progesterone receptor signaling pathway; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; response to DNA damage stimulus; ubiquitin-protein ligase activity; zinc ion binding IPR024725; IPR000569; IPR002004; IPR009091; IPR003126; IPR013993; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase UBR5 (EC 6.3.2.-) (100 kDa protein) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog)" Ubr5 Dd5 Edd Edd1 Hyd Rattus norvegicus (Rat) TR15036_c1_g1_i1 Q2LK54 COL12_CHICK 7.00E-09 GO:0030246; GO:0005581; GO:0016021; GO:0046872 carbohydrate binding; collagen; integral to membrane; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-12 (Collectin-3) (CL-3) (cCL-3) COLEC12 CL3 Gallus gallus (Chicken) TR15037_c0_g1_i1 P16157 ANK1_HUMAN 1.00E-23 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR15037_c1_g1_i1 Q6DRG7 MYPT1_DANRE 3.00E-10 GO:0071889; GO:0072357; GO:0051017; GO:0005737; GO:0001889; GO:0019208; GO:0030155; GO:0035507 14-3-3 protein binding; PTW/PP1 phosphatase complex; actin filament bundle assembly; cytoplasm; liver development; phosphatase regulator activity; regulation of cell adhesion; regulation of myosin-light-chain-phosphatase activity IPR002110; IPR020683; IPR017401; Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) ppp1r12a mbs mypt1 si:dkey-28j4.1 zgc:110448 Danio rerio (Zebrafish) (Brachydanio rerio) TR15037_c2_g1_i1 O75832 PSD10_HUMAN 4.00E-12 GO:0006977; GO:0000082; GO:0015629; GO:0031145; GO:0002479; GO:0006915; GO:0007253; GO:0005829; GO:0010467; GO:0045111; GO:0016071; GO:0043518; GO:0043409; GO:0032088; GO:0043066; GO:0090201; GO:0000122; GO:0051436; GO:0005654; GO:0030307; GO:0045737; GO:0032436; GO:0051437; GO:0005838; GO:0070682; GO:0000209; GO:0006521; GO:0044281; GO:0016032 P43358; P43686 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G1/S transition of mitotic cell cycle; actin cytoskeleton; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic process; cytoplasmic sequestering of NF-kappaB; cytosol; gene expression; intermediate filament cytoskeleton; mRNA metabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of MAPK cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of apoptotic process; negative regulation of release of cytochrome c from mitochondria; negative regulation of transcription from RNA polymerase II promoter; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of cell growth; positive regulation of cyclin-dependent protein kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; proteasome regulatory particle; proteasome regulatory particle assembly; protein polyubiquitination; regulation of cellular amino acid metabolic process; small molecule metabolic process; viral process" IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK)) PSMD10 Homo sapiens (Human) TR15041_c3_g1_i1 Q60636 PRDM1_MOUSE 9.00E-06 GO:0003677; GO:0045165; GO:0005737; GO:0042462; GO:0007281; GO:0042826; GO:0001893; GO:0046872; GO:0008168; GO:0007275; GO:0030889; GO:0031665; GO:0000122; GO:0005634; GO:0045579; GO:0010628; GO:0006355; GO:0043565; GO:0006351; GO:0060707 P63165 "DNA binding; cell fate commitment; cytoplasm; eye photoreceptor cell development; germ cell development; histone deacetylase binding; maternal placenta development; metal ion binding; methyltransferase activity; multicellular organismal development; negative regulation of B cell proliferation; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of B cell differentiation; positive regulation of gene expression; regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription, DNA-dependent; trophoblast giant cell differentiation" IPR001214; IPR007087; IPR015880; IPR013087; IPR016608; PR domain zinc finger protein 1 (EC 2.1.1.-) (B lymphocyte-induced maturation protein 1) (Blimp-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) Prdm1 Blimp1 Mus musculus (Mouse) TR15049_c1_g1_i1 Q8BX70 VP13C_MOUSE 1.00E-17 IPR015412; IPR026847; IPR026854; IPR009543; Vacuolar protein sorting-associated protein 13C Vps13c Kiaa3021 Mus musculus (Mouse) TR15049_c2_g1_i1 Q9BGZ0 VP13A_MACFA 3.00E-15 GO:0015031 protein transport IPR015412; IPR026847; Vacuolar protein sorting-associated protein 13A (Chorea-acanthocytosis protein homolog) (Chorein) (Fragment) VPS13A CHAC QflA-11022 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR15055_c0_g1_i1 A8P5H7 AMPP1_COPC7 4.00E-18 GO:0004177; GO:0009987; GO:0046872; GO:0008237; GO:0006508 aminopeptidase activity; cellular process; metal ion binding; metallopeptidase activity; proteolysis IPR000587; IPR000994; Probable Xaa-Pro aminopeptidase P (AMPP) (Aminopeptidase P) (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Prolidase) AMPP CC1G_05499 Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata) TR15062_c0_g2_i1 Q5JUK3 KCNT1_HUMAN 2.00E-17 GO:0015269; GO:0005249; GO:0008076 calcium-activated potassium channel activity; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR013099; IPR003929; IPR016040; Potassium channel subfamily T member 1 (KCa4.1) KCNT1 KIAA1422 Homo sapiens (Human) TR15068_c1_g2_i1 Q9BZA8 PC11Y_HUMAN 3.00E-14 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR013164; IPR013585; Protocadherin-11 Y-linked (Protocadherin-11) (Protocadherin on the Y chromosome) (PCDH-Y) (Protocadherin prostate cancer) (Protocadherin-PC) (Protocadherin-22) PCDH11Y PCDH11 PCDH22 PCDHY Homo sapiens (Human) TR15068_c1_g3_i1 Q08174 PCDH1_HUMAN 1.00E-11 GO:0005509; GO:0005911; GO:0007267; GO:0007156; GO:0005887; GO:0007399 calcium ion binding; cell-cell junction; cell-cell signaling; homophilic cell adhesion; integral to plasma membrane; nervous system development IPR002126; IPR015919; IPR020894; IPR013164; IPR013585; Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) PCDH1 Homo sapiens (Human) TR15072_c0_g2_i1 P05549 AP2A_HUMAN 2.00E-81 GO:0005794; GO:0000978; GO:0001078; GO:0001077; GO:0000979; GO:0000980; GO:0001105; GO:0001106; GO:0021506; GO:0071711; GO:0060349; GO:0071281; GO:0005813; GO:0003682; GO:0061303; GO:0010172; GO:0048701; GO:0035115; GO:0009880; GO:0048730; GO:0061029; GO:0060325; GO:0021884; GO:0042472; GO:0003334; GO:0001822; GO:0060235; GO:0072210; GO:0043066; GO:0008285; GO:0042059; GO:2000378; GO:0010944; GO:0014032; GO:0005634; GO:0021623; GO:0003409; GO:0003404; GO:0003151; GO:0060021; GO:0030501; GO:0030335; GO:0043525; GO:0070172; GO:0042803; GO:0045595; GO:0045664; GO:0010842; GO:0007605; GO:0043565; GO:0048485; GO:0003713; GO:0021559 Q09472; P06748 Golgi apparatus; RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II transcription coactivator activity; RNA polymerase II transcription corepressor activity; anterior neuropore closure; basement membrane organization; bone morphogenesis; cellular response to iron ion; centrosome; chromatin binding; cornea development in camera-type eye; embryonic body morphogenesis; embryonic cranial skeleton morphogenesis; embryonic forelimb morphogenesis; embryonic pattern specification; epidermis morphogenesis; eyelid development in camera-type eye; face morphogenesis; forebrain neuron development; inner ear morphogenesis; keratinocyte development; kidney development; lens induction in camera-type eye; metanephric nephron development; negative regulation of apoptotic process; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of reactive oxygen species metabolic process; negative regulation of transcription by competitive promoter binding; neural crest cell development; nucleus; oculomotor nerve formation; optic cup structural organization; optic vesicle morphogenesis; outflow tract morphogenesis; palate development; positive regulation of bone mineralization; positive regulation of cell migration; positive regulation of neuron apoptotic process; positive regulation of tooth mineralization; protein homodimerization activity; regulation of cell differentiation; regulation of neuron differentiation; retina layer formation; sensory perception of sound; sequence-specific DNA binding; sympathetic nervous system development; transcription coactivator activity; trigeminal nerve development IPR004979; IPR008121; IPR013854; Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) TFAP2A AP2TF TFAP2 Homo sapiens (Human) TR15074_c0_g2_i1 Q99719 SEPT5_HUMAN 5.00E-89 GO:0005525; GO:0003924; GO:0000910; GO:0005886; GO:0017157; GO:0031105; GO:0005198; GO:0008021; GO:0016080; GO:0043195 Q9NVA2 GTP binding; GTPase activity; cytokinesis; plasma membrane; regulation of exocytosis; septin complex; structural molecule activity; synaptic vesicle; synaptic vesicle targeting; terminal bouton IPR000038; IPR027417; IPR016491; Septin-5 (Cell division control-related protein 1) (CDCrel-1) (Peanut-like protein 1) SEPT5 PNUTL1 Homo sapiens (Human) TR15075_c0_g1_i1 Q98931 LRP8_CHICK 2.00E-13 GO:0005509; GO:0006897; GO:0016021; GO:0021517 calcium ion binding; endocytosis; integral to membrane; ventral spinal cord development IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2) (Protein LR8B) LRP8 LR8B Gallus gallus (Chicken) TR15075_c0_g2_i1 Q14114 LRP8_HUMAN 5.00E-12 GO:0021541; GO:0034185; GO:0007596; GO:0005509; GO:0005901; GO:0019221; GO:0005576; GO:0016021; GO:0021819; GO:0000122; GO:0007603; GO:0032793; GO:1900006; GO:0061003; GO:0061098; GO:0006508; GO:0038025; GO:0050804; GO:0001523; GO:0030229 "ammon gyrus development; apolipoprotein binding; blood coagulation; calcium ion binding; caveola; cytokine-mediated signaling pathway; extracellular region; integral to membrane; layer formation in cerebral cortex; negative regulation of transcription from RNA polymerase II promoter; phototransduction, visible light; positive regulation of CREB transcription factor activity; positive regulation of dendrite development; positive regulation of dendritic spine morphogenesis; positive regulation of protein tyrosine kinase activity; proteolysis; reelin receptor activity; regulation of synaptic transmission; retinoid metabolic process; very-low-density lipoprotein particle receptor activity" IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2) LRP8 APOER2 Homo sapiens (Human) TR15078_c0_g2_i1 Q54P70 Y4757_DICDI 2.00E-09 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR003323; OTU domain-containing protein DDB_G0284757 (EC 3.1.2.-) DDB_G0284757 Dictyostelium discoideum (Slime mold) TR15083_c5_g1_i1 Q5SGD2 PPM1L_HUMAN 2.00E-80 GO:0000165; GO:0005789; GO:0016021; GO:0046872; GO:0006470; GO:0004722; GO:0044281; GO:0030148; GO:0007178 MAPK cascade; endoplasmic reticulum membrane; integral to membrane; metal ion binding; protein dephosphorylation; protein serine/threonine phosphatase activity; small molecule metabolic process; sphingolipid biosynthetic process; transmembrane receptor protein serine/threonine kinase signaling pathway IPR001932; IPR000222; IPR015655; Protein phosphatase 1L (EC 3.1.3.16) (Protein phosphatase 1-like) (Protein phosphatase 2C isoform epsilon) (PP2C-epsilon) PPM1L PP2CE Homo sapiens (Human) TR15087_c0_g1_i1 Q19746 INX3_CAEEL 3.00E-23 GO:0005737; GO:0005921; GO:0055077; GO:0016021; GO:0006811; GO:0005886 cytoplasm; gap junction; gap junction hemi-channel activity; integral to membrane; ion transport; plasma membrane IPR000990; Innexin-3 (Protein opu-3) inx-3 opu-3 F22F4.2 Caenorhabditis elegans TR15091_c0_g1_i1 Q689D1 TLR2_CANFA 5.00E-17 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Canis familiaris (Dog) (Canis lupus familiaris) TR15092_c0_g1_i1 Q96Q15 SMG1_HUMAN 4.00E-17 GO:0005524; GO:0006281; GO:0005829; GO:0010467; GO:0006406; GO:0046872; GO:0000184; GO:0005634; GO:0018105; GO:0046854; GO:0046777; GO:0004674; GO:0006950 P11940; Q9HAU5 "ATP binding; DNA repair; cytosol; gene expression; mRNA export from nucleus; metal ion binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus; peptidyl-serine phosphorylation; phosphatidylinositol phosphorylation; protein autophosphorylation; protein serine/threonine kinase activity; response to stress" IPR016024; IPR003152; IPR011009; IPR000403; IPR018936; IPR014009; Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (61E3.4) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) SMG1 ATX KIAA0421 LIP Homo sapiens (Human) TR15094_c8_g1_i1 O35819 KLF6_RAT 6.00E-46 GO:0071409; GO:0070301; GO:1901653; GO:0003690; GO:0046872; GO:0005634; GO:0045944; GO:0003700; GO:0006351; GO:0042060 "cellular response to cycloheximide; cellular response to hydrogen peroxide; cellular response to peptide; double-stranded DNA binding; metal ion binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; wound healing" IPR007087; IPR015880; IPR013087; Krueppel-like factor 6 (Core promoter element-binding protein) (Transcription factor Zf9) Klf6 Copeb Rattus norvegicus (Rat) TR15096_c1_g1_i1 O70342 NPY5R_MOUSE 3.00E-06 GO:0003214; GO:0005737; GO:0042755; GO:0060112; GO:0016021; GO:0016020; GO:0014050; GO:0032229; GO:0003151; GO:0001602; GO:0001601; GO:0005886; GO:0002675; GO:0048661 "cardiac left ventricle morphogenesis; cytoplasm; eating behavior; generation of ovulation cycle rhythm; integral to membrane; membrane; negative regulation of glutamate secretion; negative regulation of synaptic transmission, GABAergic; outflow tract morphogenesis; pancreatic polypeptide receptor activity; peptide YY receptor activity; plasma membrane; positive regulation of acute inflammatory response; positive regulation of smooth muscle cell proliferation" IPR000276; IPR017452; IPR000393; IPR000611; Neuropeptide Y receptor type 5 (NPY5-R) (NPY-Y5 receptor) (NPYY5-R) (Y5 receptor) Npy5r Npy5 Mus musculus (Mouse) TR15098_c0_g1_i1 Q9D1E5 LMBRL_MOUSE 2.00E-38 GO:0006897; GO:0016021; GO:0005886 endocytosis; integral to membrane; plasma membrane IPR008075; IPR006876; Protein LMBR1L (Uteroglobin receptor) Lmbr1l D15Ertd735e Kiaa1174 Mus musculus (Mouse) TR15099_c1_g1_i1 O43301 HS12A_HUMAN 5.00E-10 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR15099_c3_g1_i1 Q9CZJ2 HS12B_MOUSE 7.00E-11 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR151_c0_g1_i1 P35524 CLCN1_RAT 6.00E-28 GO:0030554; GO:0034707; GO:0005247 adenyl nucleotide binding; chloride channel complex; voltage-gated chloride channel activity IPR000644; IPR014743; IPR001807; IPR002243; "Chloride channel protein 1 (ClC-1) (Chloride channel protein, skeletal muscle)" Clcn1 Rattus norvegicus (Rat) TR151_c1_g1_i1 Q9WU45 CLCN2_CAVPO 2.00E-20 GO:0030554; GO:0060689; GO:0034707; GO:0060041; GO:0005247 adenyl nucleotide binding; cell differentiation involved in salivary gland development; chloride channel complex; retina development in camera-type eye; voltage-gated chloride channel activity IPR000644; IPR002244; IPR014743; IPR001807; Chloride channel protein 2 (ClC-2) CLCN2 Cavia porcellus (Guinea pig) TR15103_c0_g1_i1 O00339 MATN2_HUMAN 2.00E-26 GO:0007411; GO:0005604; GO:0005509; GO:0031104; GO:0008347; GO:0001764; GO:0005578; GO:0048678 O15265; O00555 axon guidance; basement membrane; calcium ion binding; dendrite regeneration; glial cell migration; neuron migration; proteinaceous extracellular matrix; response to axon injury IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR009030; IPR019466; IPR002035; Matrilin-2 MATN2 UNQ193/PRO219 Homo sapiens (Human) TR15111_c0_g1_i1 Q071E0 SET8A_DANRE 6.00E-21 GO:0051301; GO:0005694; GO:0009953; GO:0018024; GO:0007067; GO:0005634; GO:0010628; GO:0006355; GO:0006351 "cell division; chromosome; dorsal/ventral pattern formation; histone-lysine N-methyltransferase activity; mitosis; nucleus; positive regulation of gene expression; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR016858; IPR001214; N-lysine methyltransferase SETD8-A (EC 2.1.1.-) (Histone-lysine N-methyltransferase SETD8-A) (EC 2.1.1.43) (SET domain-containing protein 8-A) setd8a set8a setd8 zgc:153719 Danio rerio (Zebrafish) (Brachydanio rerio) TR15111_c0_g2_i1 Q22795 SET1_CAEEL 2.00E-13 GO:0009792; GO:0034968; GO:0018024; GO:0005634; GO:0006355; GO:0006351 "embryo development ending in birth or egg hatching; histone lysine methylation; histone-lysine N-methyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR016858; IPR001214; Probable histone-lysine N-methyltransferase set-1 (EC 2.1.1.43) set-1 T26A5.7 Caenorhabditis elegans TR15115_c0_g1_i1 Q9GKW8 AND1A_MACFA 2.00E-24 GO:0007165 signal transduction IPR002110; IPR020683; IPR011029; IPR000488; Ankyrin repeat and death domain-containing protein 1A (Fragment) ANKDD1A QccE-18247 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR15116_c0_g1_i1 Q75WF2 DNA2_ACAPL 8.00E-52 GO:0006259; GO:0006915; GO:0004531; GO:0005576; GO:0090305 DNA metabolic process; apoptotic process; deoxyribonuclease II activity; extracellular region; nucleic acid phosphodiester bond hydrolysis IPR004947; Plancitoxin-1 (EC 3.1.22.1) (Plancitoxin I) (Plan-I) [Cleaved into: Plancitoxin-1 subunit alpha; Plancitoxin-1 subunit beta] Acanthaster planci (Crown-of-thorns starfish) TR15128_c1_g1_i1 Q6NS59 F135A_MOUSE 1.00E-18 IPR022122; IPR007751; Protein FAM135A Fam135a Mus musculus (Mouse) TR15148_c0_g1_i1 Q502K2 SAMH1_DANRE 9.00E-06 GO:0003723; GO:0051607; GO:0045087; GO:0008152; GO:0046872; GO:0005634; GO:0008081; GO:0045088 RNA binding; defense response to virus; innate immune response; metabolic process; metal ion binding; nucleus; phosphoric diester hydrolase activity; regulation of innate immune response IPR003607; IPR006674; IPR001660; IPR013761; IPR011510; Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) samhd1 Danio rerio (Zebrafish) (Brachydanio rerio) TR15158_c1_g1_i1 Q8JHV9 BIR7A_XENLA 1.00E-45 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR15166_c0_g1_i1 Q9UK73 FEM1B_HUMAN 3.00E-32 GO:0006915; GO:0060442; GO:0005737; GO:0005123; GO:0060743; GO:0005634; GO:2000001; GO:1902041; GO:0051438; GO:0004842 P49593 apoptotic process; branching involved in prostate gland morphogenesis; cytoplasm; death receptor binding; epithelial cell maturation involved in prostate gland development; nucleus; regulation of DNA damage checkpoint; regulation of extrinsic apoptotic signaling pathway via death domain receptors; regulation of ubiquitin-protein ligase activity; ubiquitin-protein ligase activity IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha) FEM1B F1AA KIAA0396 Homo sapiens (Human) TR15166_c1_g1_i1 Q9SAR5 AKR2_ARATH 6.00E-06 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 2 (AtAKR2) AKR2 AFT At4g35450 F15J1.20 Arabidopsis thaliana (Mouse-ear cress) TR15189_c0_g1_i1 A5PK27 R144B_BOVIN 3.00E-15 GO:0006915; GO:0016021; GO:0016874; GO:0031966; GO:0016567; GO:0008270 apoptotic process; integral to membrane; ligase activity; mitochondrial membrane; protein ubiquitination; zinc ion binding IPR002867; IPR001841; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF144B (EC 6.3.2.-) (RING finger protein 144B) RNF144B Bos taurus (Bovine) TR15189_c1_g1_i1 Q6DH94 R1442_DANRE 2.00E-20 GO:0016021; GO:0016874; GO:0016567; GO:0008270 integral to membrane; ligase activity; protein ubiquitination; zinc ion binding IPR002867; IPR001841; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase RNF144A-B (EC 6.3.2.-) (RING finger protein 144A-B) rnf144ab rnf144 rnf144a si:dkeyp-7f8.1 zgc:92582 Danio rerio (Zebrafish) (Brachydanio rerio) TR15196_c2_g3_i1 Q9Z0L0 TPBG_MOUSE 5.00E-06 GO:0005783; GO:0016021 endoplasmic reticulum; integral to membrane IPR000483; IPR001611; IPR003591; IPR000372; Trophoblast glycoprotein (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) Tpbg 5t4 Mus musculus (Mouse) TR152_c0_g1_i1 Q9NRC8 SIR7_HUMAN 6.00E-36 GO:0070403; GO:0097372; GO:0003682; GO:0005737; GO:0070932; GO:0046872; GO:0000122; GO:0005731; GO:0007072; GO:0009303 NAD+ binding; NAD-dependent histone deacetylase activity (H3-K18 specific); chromatin binding; cytoplasm; histone H3 deacetylation; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleolus organizer region; positive regulation of transcription on exit from mitosis; rRNA transcription IPR003000; IPR026590; NAD-dependent protein deacetylase sirtuin-7 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7) SIRT7 SIR2L7 Homo sapiens (Human) TR15202_c0_g1_i1 Q9VEU5 GCYDB_DROME 4.00E-22 GO:0005525; GO:0006184; GO:0004383; GO:0008074; GO:0020037; GO:0035556; GO:0046872; GO:0055093; GO:0001666; GO:0000302 "GTP binding; GTP catabolic process; guanylate cyclase activity; guanylate cyclase complex, soluble; heme binding; intracellular signal transduction; metal ion binding; response to hyperoxia; response to hypoxia; response to reactive oxygen species" IPR001054; IPR018297; IPR011645; IPR011644; IPR024096; Soluble guanylate cyclase 89Db (EC 4.6.1.2) Gyc-89Db CG14886 Drosophila melanogaster (Fruit fly) TR15202_c1_g1_i1 P18910 ANPRA_RAT 1.00E-59 GO:0005524; GO:0005525; GO:0007166; GO:0042417; GO:0004383; GO:0016021; GO:0035556; GO:0016941; GO:0048662; GO:0017046; GO:0005886; GO:0030828; GO:0004672; GO:0019901; GO:0007168; GO:0050880 ATP binding; GTP binding; cell surface receptor signaling pathway; dopamine metabolic process; guanylate cyclase activity; integral to membrane; intracellular signal transduction; natriuretic peptide receptor activity; negative regulation of smooth muscle cell proliferation; peptide hormone binding; plasma membrane; positive regulation of cGMP biosynthetic process; protein kinase activity; protein kinase binding; receptor guanylyl cyclase signaling pathway; regulation of blood vessel size IPR001054; IPR018297; IPR001828; IPR011009; IPR001170; IPR028082; IPR000719; IPR001245; Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) Npr1 Rattus norvegicus (Rat) TR15202_c2_g1_i1 P11528 GCY_ARBPU 5.00E-21 GO:0005524; GO:0005525; GO:0004383; GO:0016021; GO:0004672 ATP binding; GTP binding; guanylate cyclase activity; integral to membrane; protein kinase activity IPR001828; IPR011009; IPR028082; IPR000719; IPR001245; Resact receptor (EC 4.6.1.2) (Guanylate cyclase) Arbacia punctulata (Punctuate sea urchin) TR15203_c0_g1_i1 Q7RTY0 MOT13_HUMAN 2.00E-18 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 13 (MCT 13) (Solute carrier family 16 member 13) SLC16A13 MCT13 Homo sapiens (Human) TR15204_c1_g1_i1 P09480 ACHA2_CHICK 4.00E-26 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 Gallus gallus (Chicken) TR15209_c1_g1_i1 Q6P2X9 MOT12_XENTR 8.00E-07 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR15210_c0_g2_i1 Q7ZYD9 A13CB_XENLA 1.00E-99 GO:0005789 endoplasmic reticulum membrane IPR021832; IPR002110; IPR020683; Ankyrin repeat domain-containing protein 13C-B ankrd13c-b Xenopus laevis (African clawed frog) TR15211_c0_g1_i1 Q3TUU5 TEX30_MOUSE 5.00E-58 IPR026555; Testis-expressed sequence 30 protein Tex30 Mus musculus (Mouse) TR15216_c0_g1_i1 O96102 CALM_PHYPO 7.00E-17 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Physarum polycephalum (Slime mold) TR15226_c0_g1_i2 Q5XHX6 TXND2_RAT 3.00E-08 GO:0030154; GO:0045454; GO:0005737; GO:0006662; GO:0007275; GO:0005730; GO:0001520; GO:0015035; GO:0007283 cell differentiation; cell redox homeostasis; cytoplasm; glycerol ether metabolic process; multicellular organismal development; nucleolus; outer dense fiber; protein disulfide oxidoreductase activity; spermatogenesis IPR005746; IPR012336; IPR013766; Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) Txndc2 Sptrx Sptrx1 Rattus norvegicus (Rat) TR15239_c0_g1_i1 P18172 DHGL_DROPS 2.00E-13 GO:0006066; GO:0008812; GO:0005576; GO:0050660 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR1524_c0_g1_i1 Q8R151 ZNFX1_MOUSE 2.00E-21 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR15240_c0_g1_i1 Q9EPL2 CSTN1_MOUSE 1.00E-15 GO:0000139; GO:0005509; GO:0030054; GO:0042995; GO:0006874; GO:0005789; GO:0005576; GO:0007156; GO:0016021; GO:0005634; GO:0045211; GO:0007268 Q8CD76 Golgi membrane; calcium ion binding; cell junction; cell projection; cellular calcium ion homeostasis; endoplasmic reticulum membrane; extracellular region; homophilic cell adhesion; integral to membrane; nucleus; postsynaptic membrane; synaptic transmission IPR002126; IPR015919; IPR026914; IPR008985; IPR013320; Calsyntenin-1 (Alcadein-alpha) (Alc-alpha) [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)] Clstn1 Cs1 Cstn1 Kiaa0911 Mus musculus (Mouse) TR15241_c0_g1_i1 Q622X0 UNC58_CAEBR 1.00E-06 GO:0016021; GO:0040011; GO:0006936; GO:0007567; GO:0005267 integral to membrane; locomotion; muscle contraction; parturition; potassium channel activity IPR003280; IPR013099; Uncoordinated protein 58 unc-58 CBG01980 Caenorhabditis briggsae TR15241_c0_g2_i1 P97438 KCNK2_MOUSE 3.00E-31 GO:0007186; GO:0030322; GO:0005249; GO:0008076 G-protein coupled receptor signaling pathway; stabilization of membrane potential; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR003280; IPR013099; IPR003976; Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two pore potassium channel TPKC1) Kcnk2 Mus musculus (Mouse) TR15255_c1_g1_i1 Q38RX1 COX2_PRAJA 5.00E-25 GO:0005507; GO:0004129; GO:0022900; GO:0016021; GO:0005743; GO:0045277 copper ion binding; cytochrome-c oxidase activity; electron transport chain; integral to membrane; mitochondrial inner membrane; respiratory chain complex IV IPR001505; IPR008972; IPR014222; IPR002429; IPR011759; Cytochrome c oxidase subunit 2 (Cytochrome c oxidase polypeptide II) MT-CO2 COII COXII MTCO2 Praomys jacksoni (African forest rat) (Jackson's soft-furred mouse) TR15257_c1_g1_i1 Q6P5E8 DGKQ_MOUSE 1.00E-62 GO:0005524; GO:0003951; GO:0019933; GO:0005856; GO:0005829; GO:0004143; GO:0046872; GO:0016607; GO:0005886; GO:0070528; GO:0007205; GO:0033198; GO:0070493 ATP binding; NAD+ kinase activity; cAMP-mediated signaling; cytoskeleton; cytosol; diacylglycerol kinase activity; metal ion binding; nuclear speck; plasma membrane; protein kinase C signaling cascade; protein kinase C-activating G-protein coupled receptor signaling pathway; response to ATP; thrombin receptor signaling pathway IPR016064; IPR020454; IPR000756; IPR001206; IPR002219; IPR000159; Diacylglycerol kinase theta (DAG kinase theta) (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) Dgkq Mus musculus (Mouse) TR15257_c3_g2_i1 Q6NS52 DGKB_MOUSE 1.00E-31 GO:0005524; GO:0003951; GO:0005509; GO:0005737; GO:0004143; GO:0035556; GO:0005886; GO:0007205 ATP binding; NAD+ kinase activity; calcium ion binding; cytoplasm; diacylglycerol kinase activity; intracellular signal transduction; plasma membrane; protein kinase C-activating G-protein coupled receptor signaling pathway IPR016064; IPR000756; IPR001206; IPR011992; IPR018247; IPR002048; IPR002219; Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) Dgkb Kiaa0718 Mus musculus (Mouse) TR15257_c3_g3_i1 Q9R1C6 DGKE_MOUSE 2.00E-31 GO:0005524; GO:0003951; GO:0005737; GO:0004143; GO:0016021; GO:0035556; GO:0046872; GO:0007205 ATP binding; NAD+ kinase activity; cytoplasm; diacylglycerol kinase activity; integral to membrane; intracellular signal transduction; metal ion binding; protein kinase C-activating G-protein coupled receptor signaling pathway IPR016064; IPR000756; IPR001206; IPR002219; Diacylglycerol kinase epsilon (DAG kinase epsilon) (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) Dgke Mus musculus (Mouse) TR15268_c1_g1_i1 O42569 SOX2_XENLA 3.00E-73 GO:0030154; GO:0007399; GO:0005634; GO:0045944; GO:0043565; GO:0006351 "cell differentiation; nervous system development; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent" IPR009071; IPR022097; Transcription factor Sox-2 (XSox2) (XlSox-2) (SRY (sex determining region Y)-box 2) sox2 Xenopus laevis (African clawed frog) TR15268_c1_g2_i1 Q6RVD7 SX21B_DANRE 1.00E-53 GO:0002088; GO:0000122; GO:0005634; GO:0043565; GO:0006351 "lens development in camera-type eye; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding; transcription, DNA-dependent" IPR009071; IPR022097; Transcription factor Sox-21-B (SRY-box containing gene 21b) sox21b si:ch211-247e2.1 zgc:110678 Danio rerio (Zebrafish) (Brachydanio rerio) TR15273_c0_g1_i1 Q6NMM8 F8H_ARATH 3.00E-08 GO:0005794; GO:0000139; GO:0010417; GO:0016021; GO:0016757 "Golgi apparatus; Golgi membrane; glucuronoxylan biosynthetic process; integral to membrane; transferase activity, transferring glycosyl groups" IPR004263; Probable glucuronoxylan glucuronosyltransferase F8H (EC 2.4.1.-) (FRA8 homolog) (Protein FRAGILE FIBER 8 homolog) F8H At5g22940 MRN17.17 Arabidopsis thaliana (Mouse-ear cress) TR15277_c2_g1_i1 P51143 SC6A2_BOVIN 9.00E-51 GO:0005887; GO:0005328 integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR002435; Sodium-dependent noradrenaline transporter (Norepinephrine transporter) (NET) (Solute carrier family 6 member 2) SLC6A2 NORADR Bos taurus (Bovine) TR1528_c0_g1_i1 P49165 RL4_URECA 0 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR025755; IPR002136; IPR013000; IPR023574; 60S ribosomal protein L4 (L1) RPL4 RPL1 Urechis caupo (Innkeeper worm) (Spoonworm) TR15280_c1_g1_i1 Q9TWL9 COMA_CONMA 9.00E-09 GO:0005576; GO:0016042; GO:0004623 extracellular region; lipid catabolic process; phospholipase A2 activity IPR016090; Conodipine-M alpha chain (PLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) Conus magus (Magus cone) (Magician's cone snail) TR15286_c3_g1_i1 P31646 S6A13_RAT 1.00E-17 GO:0005332; GO:0005887; GO:0042165; GO:0006836; GO:0005328 gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; neurotransmitter binding; neurotransmitter transport; neurotransmitter:sodium symporter activity IPR000175; IPR002981; Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13) Slc6a13 Gabt2 Gat-2 Rattus norvegicus (Rat) TR15294_c0_g1_i1 Q2V897 TLR2_BOSTR 2.00E-07 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Boselaphus tragocamelus (Nilgai) TR15294_c0_g2_i1 Q6R5P0 TLR11_MOUSE 5.00E-13 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0009617; GO:0034170; GO:0004888 E1WGJ5 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to bacterium; toll-like receptor 11 signaling pathway; transmembrane signaling receptor activity IPR003591; IPR000157; IPR027194; Toll-like receptor 11 Tlr11 Gm287 Mus musculus (Mouse) TR15296_c0_g1_i1 Q8AVY1 ODF3A_XENLA 8.00E-63 GO:0005737 cytoplasm IPR010736; Outer dense fiber protein 3 (Outer dense fiber of sperm tails protein 3) odf3 Xenopus laevis (African clawed frog) TR15297_c0_g1_i1 Q28J44 S39AB_XENTR 5.00E-104 GO:0016021; GO:0046873; GO:0006829 integral to membrane; metal ion transmembrane transporter activity; zinc ion transport IPR003689; Zinc transporter ZIP11 (Solute carrier family 39 member 11) (Zrt- and Irt-like protein 11) (ZIP-11) slc39a11 zip11 TNeu027c15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR153_c0_g1_i1 Q108T9 CTTB2_LOXAF 4.00E-07 GO:0005938; GO:0043197 cell cortex; dendritic spine IPR002110; IPR020683; IPR019131; Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Loxodonta africana (African elephant) TR15303_c3_g1_i1 Q8NFA0 UBP32_HUMAN 2.00E-36 GO:0005794; GO:0005509; GO:0008234; GO:0016020; GO:0016579; GO:0004221; GO:0006511 Golgi apparatus; calcium ion binding; cysteine-type peptidase activity; membrane; protein deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR011992; IPR018247; IPR002048; IPR006615; IPR018200; IPR001394; IPR001125; IPR028135; Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) USP32 USP10 Homo sapiens (Human) TR15306_c0_g1_i1 P0A4A5 RS12_STRLI 2.00E-09 GO:0019843; GO:0046677; GO:0015935; GO:0003735; GO:0000049; GO:0006412 rRNA binding; response to antibiotic; small ribosomal subunit; structural constituent of ribosome; tRNA binding; translation IPR012340; IPR006032; IPR005679; 30S ribosomal protein S12 rpsL Streptomyces lividans TR15306_c0_g3_i1 Q86FP7 RS23_DERVA 7.00E-92 GO:0015935; GO:0003735; GO:0006412 small ribosomal subunit; structural constituent of ribosome; translation IPR012340; IPR006032; IPR005680; 40S ribosomal protein S23 RpS23 Dermacentor variabilis (American dog tick) TR15310_c0_g1_i1 Q8Q0U0 Y045_METMA 3.00E-35 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR15311_c0_g1_i1 Q00690 LYAM2_MOUSE 3.00E-06 GO:0030029; GO:0007202; GO:0005901; GO:0005905; GO:0030863; GO:0005615; GO:0007157; GO:0016021; GO:0050901; GO:0070492; GO:0048471; GO:0002687; GO:0002092; GO:0070555; GO:0033691; GO:0004888 actin filament-based process; activation of phospholipase C activity; caveola; coated pit; cortical cytoskeleton; extracellular space; heterophilic cell-cell adhesion; integral to membrane; leukocyte tethering or rolling; oligosaccharide binding; perinuclear region of cytoplasm; positive regulation of leukocyte migration; positive regulation of receptor internalization; response to interleukin-1; sialic acid binding; transmembrane signaling receptor activity IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR002396; IPR000436; E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E) Sele Elam-1 Mus musculus (Mouse) TR15314_c1_g1_i2 Q9V4M2 WECH_DROME 7.00E-07 GO:0030154; GO:0002168; GO:0005622; GO:0016203; GO:0005927; GO:0033632; GO:0008270 cell differentiation; instar larval development; intracellular; muscle attachment; muscle tendon junction; regulation of cell-cell adhesion mediated by integrin; zinc ion binding IPR011042; IPR001258; IPR013017; IPR000315; Protein wech (Protein dappled) wech dpld CG42396 Drosophila melanogaster (Fruit fly) TR15315_c1_g1_i1 Q9C098 DCLK3_HUMAN 1.00E-46 GO:0005524; GO:0005737; GO:0005634; GO:0004674 ATP binding; cytoplasm; nucleus; protein serine/threonine kinase activity IPR020636; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase DCLK3 (EC 2.7.11.1) (Doublecortin domain-containing protein 3C) (Doublecortin-like and CAM kinase-like 3) (Doublecortin-like kinase 3) DCLK3 DCAMKL3 DCDC3C KIAA1765 Homo sapiens (Human) TR15322_c2_g1_i1 P0C032 RUB3_ORYSJ 2.00E-08 GO:0005737; GO:0005634 cytoplasm; nucleus IPR019956; IPR019954; IPR000626; Ubiquitin-like protein-NEDD8-like protein RUB3 [Cleaved into: Ubiquitin-like protein; NEDD8-like protein RUB3 (OsRUB3) (Ubiquitin-related protein 3)] RUB3 NEDD8 UBL1 Os01g0641600 LOC_Os01g45400 P0039G05.16 P0510C12.1 Oryza sativa subsp. japonica (Rice) TR15323_c1_g1_i1 P59240 NPHP4_MOUSE 2.00E-06 GO:0005911; GO:0005813; GO:0005929; GO:0005737; GO:0005932; GO:0060041; GO:0005923 Q9QY53; Q8CG73 cell-cell junction; centrosome; cilium; cytoplasm; microtubule basal body; retina development in camera-type eye; tight junction Nephrocystin-4 (Nephroretinin) Nphp4 Mus musculus (Mouse) TR15328_c0_g1_i1 Q6P9H5 GIMA6_HUMAN 2.00E-16 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 6 (Immunity-associated nucleotide 2 protein) (IAN-2) (hIAN2) (Immunity-associated nucleotide 6 protein) (IAN-6) (hIAN6) GIMAP6 IAN2 IAN6 Homo sapiens (Human) TR15331_c0_g1_i1 Q8R151 ZNFX1_MOUSE 5.00E-31 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR15334_c1_g1_i1 Q01622 HLOX2_HELRO 9.00E-47 GO:0007275; GO:0005634; GO:0043565; GO:0003700 multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein LOX2 (Fragment) LOX2 Helobdella robusta (Californian leech) TR15337_c1_g1_i1 Q9NGQ2 KIF1_DICDI 2.00E-44 GO:0005524; GO:0030659; GO:0005871; GO:0005874; GO:0003777; GO:0007018; GO:0005543; GO:0006810 ATP binding; cytoplasmic vesicle membrane; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement; phospholipid binding; transport IPR000253; IPR022140; IPR027640; IPR019821; IPR001752; IPR027417; IPR011993; IPR001849; IPR008984; Kinesin-related protein 1 (Kinesin family member 1) (Kinesin-3) kif1 kif1A unc104 DDB_G0290963 Dictyostelium discoideum (Slime mold) TR15337_c1_g2_i1 O43896 KIF1C_HUMAN 7.00E-43 GO:0005524; GO:0005794; GO:0005783; GO:0005871; GO:0005874; GO:0003777; GO:0007018; GO:0003774; GO:0006890 A0JNT9 "ATP binding; Golgi apparatus; endoplasmic reticulum; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement; motor activity; retrograde vesicle-mediated transport, Golgi to ER" IPR000253; IPR027640; IPR019821; IPR001752; IPR027417; IPR008984; Kinesin-like protein KIF1C KIF1C KIAA0706 Homo sapiens (Human) TR15346_c0_g1_i1 Q28199 CD5R1_BOVIN 9.00E-10 GO:0007213; GO:0030424; GO:0007411; GO:0007413; GO:0007420; GO:0045296; GO:0005509; GO:0021799; GO:0043292; GO:0016534; GO:0016533; GO:0043197; GO:0009790; GO:0048013; GO:0030426; GO:0035235; GO:0016301; GO:0016020; GO:0045892; GO:0031594; GO:0007158; GO:0001764; GO:0043025; GO:0005634; GO:0018105; GO:0018107; GO:0048471; GO:0005886; GO:0043525; GO:0014069; GO:0043539; GO:0032956; GO:0061001; GO:0070507 "G-protein coupled acetylcholine receptor signaling pathway; axon; axon guidance; axonal fasciculation; brain development; cadherin binding; calcium ion binding; cerebral cortex radially oriented cell migration; contractile fiber; cyclin-dependent protein kinase 5 activator activity; cyclin-dependent protein kinase 5 holoenzyme complex; dendritic spine; embryo development; ephrin receptor signaling pathway; growth cone; ionotropic glutamate receptor signaling pathway; kinase activity; membrane; negative regulation of transcription, DNA-dependent; neuromuscular junction; neuron cell-cell adhesion; neuron migration; neuronal cell body; nucleus; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; perinuclear region of cytoplasm; plasma membrane; positive regulation of neuron apoptotic process; postsynaptic density; protein serine/threonine kinase activator activity; regulation of actin cytoskeleton organization; regulation of dendritic spine morphogenesis; regulation of microtubule cytoskeleton organization" IPR004944; IPR013763; "Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)]" CDK5R1 CDK5R NCK5A Bos taurus (Bovine) TR15349_c0_g1_i1 P28828 PTPRM_MOUSE 3.00E-20 GO:0045296; GO:0005913; GO:0007156; GO:0016021; GO:0030027; GO:0016525; GO:0010596; GO:0001937; GO:0048471; GO:0045909; GO:0042493; GO:0010842; GO:0031290; GO:0005001 cadherin binding; cell-cell adherens junction; homophilic cell adhesion; integral to membrane; lamellipodium; negative regulation of angiogenesis; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; perinuclear region of cytoplasm; positive regulation of vasodilation; response to drug; retina layer formation; retinal ganglion cell axon guidance; transmembrane receptor protein tyrosine phosphatase activity IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR013151; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Ptprm Kiaa4044 Mus musculus (Mouse) TR15352_c0_g1_i1 Q9VBW3 CAD96_DROME 4.00E-17 GO:0005524; GO:0007030; GO:0005509; GO:0016339; GO:0007156; GO:0005887; GO:0045792; GO:0004713; GO:0004714 ATP binding; Golgi organization; calcium ion binding; calcium-dependent cell-cell adhesion; homophilic cell adhesion; integral to plasma membrane; negative regulation of cell size; protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity IPR002126; IPR015919; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14) Cad96Ca HD-14 CG10244 Drosophila melanogaster (Fruit fly) TR15361_c0_g1_i1 Q7ZXS8 CALRL_XENLA 8.00E-13 GO:0004948; GO:0016021; GO:0005886 calcitonin receptor activity; integral to membrane; plasma membrane IPR003287; IPR017981; IPR003289; IPR001879; IPR000832; IPR017983; Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) calcrl Xenopus laevis (African clawed frog) TR15362_c0_g2_i1 P07996 TSP1_HUMAN 2.00E-23 GO:0000187; GO:0048266; GO:0005509; GO:0007155; GO:0007050; GO:0016477; GO:0034605; GO:0002544; GO:0070052; GO:0003197; GO:0043652; GO:0009897; GO:0031012; GO:0030198; GO:0070062; GO:0070051; GO:0005577; GO:0017134; GO:0001968; GO:0003417; GO:0008201; GO:0042802; GO:0006955; GO:0005178; GO:0043236; GO:0030169; GO:0016525; GO:0002581; GO:0043066; GO:0043537; GO:0010754; GO:0043154; GO:0002605; GO:0001937; GO:2001237; GO:0051918; GO:0040037; GO:0051895; GO:0032695; GO:0010751; GO:0010748; GO:0010757; GO:0003151; GO:0018149; GO:0001786; GO:0030168; GO:0031093; GO:0002576; GO:0045766; GO:0043536; GO:0010811; GO:2000353; GO:1900119; GO:1902043; GO:0010763; GO:0043032; GO:0010759; GO:0051897; GO:2000379; GO:0030511; GO:0032914; GO:0045727; GO:0042535; GO:0043394; GO:0051592; GO:0042493; GO:0034976; GO:0009749; GO:0001666; GO:0032026; GO:0032570; GO:0016529; GO:0002040; GO:0050431 P01137 activation of MAPK activity; behavioral response to pain; calcium ion binding; cell adhesion; cell cycle arrest; cell migration; cellular response to heat; chronic inflammatory response; collagen V binding; endocardial cushion development; engulfment of apoptotic cell; external side of plasma membrane; extracellular matrix; extracellular matrix organization; extracellular vesicular exosome; fibrinogen binding; fibrinogen complex; fibroblast growth factor binding; fibronectin binding; growth plate cartilage development; heparin binding; identical protein binding; immune response; integrin binding; laminin binding; low-density lipoprotein particle binding; negative regulation of angiogenesis; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; negative regulation of apoptotic process; negative regulation of blood vessel endothelial cell migration; negative regulation of cGMP-mediated signaling; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of dendritic cell antigen processing and presentation; negative regulation of endothelial cell proliferation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of fibrinolysis; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of focal adhesion assembly; negative regulation of interleukin-12 production; negative regulation of nitric oxide mediated signal transduction; negative regulation of plasma membrane long-chain fatty acid transport; negative regulation of plasminogen activation; outflow tract morphogenesis; peptide cross-linking; phosphatidylserine binding; platelet activation; platelet alpha granule lumen; platelet degranulation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell-substrate adhesion; positive regulation of endothelial cell apoptotic process; positive regulation of execution phase of apoptosis; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of fibroblast migration; positive regulation of macrophage activation; positive regulation of macrophage chemotaxis; positive regulation of protein kinase B signaling cascade; positive regulation of reactive oxygen species metabolic process; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of transforming growth factor beta1 production; positive regulation of translation; positive regulation of tumor necrosis factor biosynthetic process; proteoglycan binding; response to calcium ion; response to drug; response to endoplasmic reticulum stress; response to glucose stimulus; response to hypoxia; response to magnesium ion; response to progesterone stimulus; sarcoplasmic reticulum; sprouting angiogenesis; transforming growth factor beta binding IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR001791; IPR000884; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-1 THBS1 TSP TSP1 Homo sapiens (Human) TR15365_c0_g1_i1 Q5UNW9 YR718_MIMIV 2.00E-08 IPR025475; Uncharacterized protein R718 MIMI_R718 Acanthamoeba polyphaga mimivirus (APMV) TR15371_c0_g2_i1 Q9J507 V228_FOWPN 2.00E-07 IPR002110; IPR020683; IPR018272; Putative ankyrin repeat protein FPV228 FPV228 Fowlpox virus (strain NVSL) (FPV) TR15375_c0_g1_i1 P13277 CYSP1_HOMAM 9.00E-06 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Digestive cysteine proteinase 1 (EC 3.4.22.-) LCP1 Homarus americanus (American lobster) TR15379_c1_g3_i1 Q49B93 SC5AC_MOUSE 2.00E-23 GO:0016324; GO:0016021; GO:0006814; GO:0015293 apical plasma membrane; integral to membrane; sodium ion transport; symporter activity IPR001734; IPR019900; Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12) Slc5a12 Smct2 Mus musculus (Mouse) TR15380_c0_g1_i2 P05099 MATN1_CHICK 7.00E-07 GO:0005578 proteinaceous extracellular matrix IPR000742; IPR013032; IPR019466; IPR002035; Cartilage matrix protein (Matrilin-1) MATN1 CMP Gallus gallus (Chicken) TR15381_c0_g1_i1 P97435 ENTK_MOUSE 3.00E-15 GO:0016021; GO:0006508; GO:0005044; GO:0004252 integral to membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity IPR008985; IPR000859; IPR023415; IPR002172; IPR000998; IPR011163; IPR001254; IPR018114; IPR001314; IPR000082; IPR001190; IPR017448; IPR009003; Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain] Tmprss15 Entk Prss7 Mus musculus (Mouse) TR15382_c0_g1_i1 O35460 ANGP1_RAT 1.00E-11 GO:0001525; GO:0030154; GO:0005615; GO:0072012; GO:0043066; GO:0031100; GO:0001541; GO:0051260; GO:0043627; GO:0001666; GO:0033552 angiogenesis; cell differentiation; extracellular space; glomerulus vasculature development; negative regulation of apoptotic process; organ regeneration; ovarian follicle development; protein homooligomerization; response to estrogen stimulus; response to hypoxia; response to vitamin B3 IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-1 (ANG-1) Angpt1 Rattus norvegicus (Rat) TR15387_c1_g1_i1 Q8BW66 S2548_MOUSE 5.00E-16 GO:0016021; GO:0005743; GO:0005739; GO:0006810 integral to membrane; mitochondrial inner membrane; mitochondrion; transport IPR018108; IPR023395; Solute carrier family 25 member 48 Slc25a48 Mus musculus (Mouse) TR15390_c1_g1_i1 P70371 TERF1_MOUSE 3.00E-06 GO:0008301; GO:0000086; GO:0001309; GO:0051301; GO:0003682; GO:0008656; GO:0005737; GO:0003691; GO:0097194; GO:0007067; GO:0007094; GO:0032211; GO:0000783; GO:0005654; GO:0031116; GO:0045840; GO:0045931; GO:0051260; GO:0005819; GO:0010521 Q6ZQJ5 "DNA binding, bending; G2/M transition of mitotic cell cycle; age-dependent telomere shortening; cell division; chromatin binding; cysteine-type endopeptidase activator activity involved in apoptotic process; cytoplasm; double-stranded telomeric DNA binding; execution phase of apoptosis; mitosis; mitotic spindle assembly checkpoint; negative regulation of telomere maintenance via telomerase; nuclear telomere cap complex; nucleoplasm; positive regulation of microtubule polymerization; positive regulation of mitosis; positive regulation of mitotic cell cycle; protein homooligomerization; spindle; telomerase inhibitor activity" IPR009057; IPR017930; IPR001005; IPR017357; IPR013867; Telomeric repeat-binding factor 1 (TTAGGG repeat-binding factor 1) Terf1 Trf1 Mus musculus (Mouse) TR15392_c2_g1_i1 Q502K3 ANR52_DANRE 1.00E-12 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) TR15401_c0_g1_i1 Q6NWH0 CK068_DANRE 4.00E-11 IPR015034; IPR023398; UPF0696 protein C11orf68 homolog P5436 zgc:63470 Danio rerio (Zebrafish) (Brachydanio rerio) TR15410_c0_g1_i1 Q91W50 CSDE1_MOUSE 3.00E-15 GO:0070937; GO:0003677; GO:0003723; GO:0005743; GO:0070966; GO:0006355 "CRD-mediated mRNA stability complex; DNA binding; RNA binding; mitochondrial inner membrane; nuclear-transcribed mRNA catabolic process, no-go decay; regulation of transcription, DNA-dependent" IPR019844; IPR011129; IPR002059; IPR012340; IPR024642; Cold shock domain-containing protein E1 Csde1 D3Jfr1 Mus musculus (Mouse) TR15415_c0_g2_i1 Q2HZX7 FUZZY_XENTR 1.00E-18 GO:0042384; GO:0005737; GO:0005856; GO:0010172; GO:0048704; GO:0001736; GO:0001843; GO:0015031; GO:0008589 Q6GNL4 cilium assembly; cytoplasm; cytoskeleton; embryonic body morphogenesis; embryonic skeletal system morphogenesis; establishment of planar polarity; neural tube closure; protein transport; regulation of smoothened signaling pathway IPR026069; Protein fuzzy homolog (Xfy) fuz fuzzy fy Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR15418_c0_g2_i1 Q13387 JIP2_HUMAN 2.00E-19 GO:0005078; GO:0000165; GO:0001662; GO:0001540; GO:0005737; GO:0048813; GO:0019894; GO:0097481; GO:0046958; GO:0030295; GO:0046328; GO:2000310; GO:2000311; GO:0060079; GO:0051966; GO:0007172; GO:0035176 P00533; P04626 "MAP-kinase scaffold activity; MAPK cascade; behavioral fear response; beta-amyloid binding; cytoplasm; dendrite morphogenesis; kinesin binding; neuronal postsynaptic density; nonassociative learning; protein kinase activator activity; regulation of JNK cascade; regulation of N-methyl-D-aspartate selective glutamate receptor activity; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; regulation of excitatory postsynaptic membrane potential; regulation of synaptic transmission, glutamatergic; signal complex assembly; social behavior" IPR011993; IPR006020; IPR001452; C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2) MAPK8IP2 IB2 JIP2 PRKM8IPL Homo sapiens (Human) TR15418_c1_g1_i1 Q9W0K0 JIP1_DROME 8.00E-25 GO:0007254; GO:0048490; GO:0019896; GO:0005737; GO:0048812; GO:0046328; GO:0048491 Itself; P14599; Q23977 JNK cascade; anterograde synaptic vesicle transport; axon transport of mitochondrion; cytoplasm; neuron projection morphogenesis; regulation of JNK cascade; retrograde synaptic vesicle transport IPR011993; IPR006020; IPR001452; JNK-interacting protein 1 (JIP-1) (APP-like-interacting protein 1) (APLIP1) (Protein eye developmental SP512) Aplip1 SP512 CG1200 Drosophila melanogaster (Fruit fly) TR15419_c2_g1_i1 Q9DBB9 CPN2_MOUSE 3.00E-10 GO:0005576 extracellular region IPR000483; IPR001611; IPR025875; IPR003591; IPR000372; Carboxypeptidase N subunit 2 (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N large subunit) (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N regulatory subunit) Cpn2 Mus musculus (Mouse) TR15419_c3_g1_i1 Q13591 SEM5A_HUMAN 4.00E-08 GO:0007411; GO:0008046; GO:0007155; GO:0007267; GO:0016021; GO:0001569; GO:0005886 axon guidance; axon guidance receptor activity; cell adhesion; cell-cell signaling; integral to membrane; patterning of blood vessels; plasma membrane IPR016201; IPR002165; IPR001627; IPR027231; IPR000884; IPR015943; Semaphorin-5A (Semaphorin-F) (Sema F) SEMA5A SEMAF Homo sapiens (Human) TR15422_c0_g1_i1 Q9NBX4 RTXE_DROME 2.00E-06 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR15432_c0_g1_i1 Q9H1U4 MEGF9_HUMAN 6.00E-13 GO:0005509; GO:0016021 calcium ion binding; integral to membrane IPR013032; IPR002049; IPR001368; Multiple epidermal growth factor-like domains protein 9 (Multiple EGF-like domains protein 9) (Epidermal growth factor-like protein 5) (EGF-like protein 5) MEGF9 EGFL5 KIAA0818 UNQ671/PRO1305 Homo sapiens (Human) TR15433_c1_g1_i1 O43451 MGA_HUMAN 2.00E-52 GO:0004558; GO:0016160; GO:0016324; GO:0030246; GO:0004339; GO:0016021; GO:0032450; GO:0005886; GO:0044245; GO:0044281; GO:0005983 "alpha-glucosidase activity; amylase activity; apical plasma membrane; carbohydrate binding; glucan 1,4-alpha-glucosidase activity; integral to membrane; maltose alpha-glucosidase activity; plasma membrane; polysaccharide digestion; small molecule metabolic process; starch catabolic process" IPR011013; IPR000322; IPR017853; IPR000519; IPR017957; "Maltase-glucoamylase, intestinal [Includes: Maltase (EC 3.2.1.20) (Alpha-glucosidase); Glucoamylase (EC 3.2.1.3) (Glucan 1,4-alpha-glucosidase)]" MGAM MGA MGAML Homo sapiens (Human) TR15436_c1_g1_i1 Q5RJI4 PKDCC_MOUSE 2.00E-39 GO:0005524; GO:0005794; GO:0030282; GO:0030154; GO:0048566; GO:0048286; GO:0035264; GO:0042997; GO:0060021; GO:0030501; GO:0032332; GO:0004672; GO:0015031; GO:0001501 ATP binding; Golgi apparatus; bone mineralization; cell differentiation; embryonic digestive tract development; lung alveolus development; multicellular organism growth; negative regulation of Golgi to plasma membrane protein transport; palate development; positive regulation of bone mineralization; positive regulation of chondrocyte differentiation; protein kinase activity; protein transport; skeletal system development IPR022049; IPR011009; IPR000719; "Protein kinase domain-containing protein, cytoplasmic (EC 2.7.-.-) (Protein kinase-like protein SgK493) (Sugen kinase 493) (Vertebrate lonesome kinase)" Pkdcc Sgk493 Vlk Mus musculus (Mouse) TR15439_c3_g1_i1 Q9NXT0 ZN586_HUMAN 2.00E-19 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 586 ZNF586 Homo sapiens (Human) TR15439_c3_g2_i1 Q9UDV7 ZN282_HUMAN 2.00E-23 GO:0003677; GO:0045892; GO:0005634; GO:0006351; GO:0008270 "DNA binding; negative regulation of transcription, DNA-dependent; nucleus; transcription, DNA-dependent; zinc ion binding" IPR022137; IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1) ZNF282 HUB1 Homo sapiens (Human) TR15439_c3_g3_i1 P0CG24 ZN883_HUMAN 3.00E-24 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 883 ZNF883 Homo sapiens (Human) TR15439_c5_g1_i1 Q8IX07 FOG1_HUMAN 9.00E-06 GO:0003677; GO:0001078; GO:0002295; GO:0060413; GO:0003181; GO:0007596; GO:0055008; GO:0005737; GO:0060318; GO:0035162; GO:0030218; GO:0030851; GO:0035855; GO:0030219; GO:0046872; GO:0003192; GO:0045599; GO:0045403; GO:0060377; GO:0032091; GO:0003151; GO:0030220; GO:0045078; GO:0060319; GO:0032642; GO:0010724; GO:0005667; GO:0071733; GO:0017053; GO:0003195; GO:0060412 P49841; Q09028 DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; T-helper cell lineage commitment; atrial septum morphogenesis; atrioventricular valve morphogenesis; blood coagulation; cardiac muscle tissue morphogenesis; cytoplasm; definitive erythrocyte differentiation; embryonic hemopoiesis; erythrocyte differentiation; granulocyte differentiation; megakaryocyte development; megakaryocyte differentiation; metal ion binding; mitral valve formation; negative regulation of fat cell differentiation; negative regulation of interleukin-4 biosynthetic process; negative regulation of mast cell differentiation; negative regulation of protein binding; outflow tract morphogenesis; platelet formation; positive regulation of interferon-gamma biosynthetic process; primitive erythrocyte differentiation; regulation of chemokine production; regulation of definitive erythrocyte differentiation; transcription factor complex; transcriptional activation by promoter-enhancer looping; transcriptional repressor complex; tricuspid valve formation; ventricular septum morphogenesis IPR007087; IPR015880; IPR013087; Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) ZFPM1 FOG1 ZFN89A Homo sapiens (Human) TR15445_c3_g1_i1 P02588 TNNC2_CHICK 8.00E-13 GO:0005509; GO:0003009; GO:0005861 calcium ion binding; skeletal muscle contraction; troponin complex IPR011992; IPR018247; IPR002048; "Troponin C, skeletal muscle" TNNC2 Gallus gallus (Chicken) TR15445_c4_g1_i1 A8CEP3 CALM_SACJA 1.00E-26 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) cam Saccharina japonica (Sweet kelp) (Laminaria japonica) TR15447_c0_g1_i1 Q8VBX0 ASB13_MOUSE 2.00E-09 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 13 (ASB-13) Asb13 Mus musculus (Mouse) TR15453_c2_g2_i1 O54983 CRYM_MOUSE 7.00E-101 GO:0050661; GO:0042562; GO:0005739; GO:0000122; GO:0005634; GO:0005886; GO:0007605; GO:0047127; GO:0070324; GO:0042403; GO:0070327; GO:0003714 NADP binding; hormone binding; mitochondrion; negative regulation of transcription from RNA polymerase II promoter; nucleus; plasma membrane; sensory perception of sound; thiomorpholine-carboxylate dehydrogenase activity; thyroid hormone binding; thyroid hormone metabolic process; thyroid hormone transport; transcription corepressor activity IPR016040; IPR003462; IPR023401; Ketimine reductase mu-crystallin (EC 1.5.1.25) (NADP-regulated thyroid-hormone-binding protein) Crym Mus musculus (Mouse) TR15483_c0_g1_i1 Q8VZI2 Y4370_ARATH 1.00E-10 GO:0030554; GO:0016021; GO:0005886 adenyl nucleotide binding; integral to membrane; plasma membrane IPR000644; IPR002550; DUF21 domain-containing protein At4g33700 (CBS domain-containing protein CBSDUF6) CBSDUF6 At4g33700 T16L1_190 Arabidopsis thaliana (Mouse-ear cress) TR15488_c1_g1_i1 Q9D826 SOX_MOUSE 2.00E-10 GO:0033514; GO:0050031; GO:0005777; GO:0008115; GO:0046653 L-lysine catabolic process to acetyl-CoA via L-pipecolate; L-pipecolate oxidase activity; peroxisome; sarcosine oxidase activity; tetrahydrofolate metabolic process IPR006076; IPR006281; Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase) Pipox Pso Mus musculus (Mouse) TR15489_c0_g1_i1 P28840 NEC1_RAT 2.00E-40 GO:0043679; GO:0030425; GO:0009790; GO:0005615; GO:0043559; GO:0022008; GO:0031016; GO:0016486; GO:0043204; GO:0048471; GO:0021983; GO:0050714; GO:0016540; GO:0006508; GO:0048678; GO:0051592; GO:0010157; GO:0042493; GO:0070542; GO:0051384; GO:0009749; GO:0070555; GO:0032496; GO:0043278; GO:0031667; GO:0043434; GO:0005791; GO:0030141; GO:0004252; GO:0005802; GO:0030133 axon terminus; dendrite; embryo development; extracellular space; insulin binding; neurogenesis; pancreas development; peptide hormone processing; perikaryon; perinuclear region of cytoplasm; pituitary gland development; positive regulation of protein secretion; protein autoprocessing; proteolysis; response to axon injury; response to calcium ion; response to chlorate; response to drug; response to fatty acid; response to glucocorticoid stimulus; response to glucose stimulus; response to interleukin-1; response to lipopolysaccharide; response to morphine; response to nutrient levels; response to peptide hormone stimulus; rough endoplasmic reticulum; secretory granule; serine-type endopeptidase activity; trans-Golgi network; transport vesicle IPR008979; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR022005; IPR009020; IPR002884; Neuroendocrine convertase 1 (NEC 1) (EC 3.4.21.93) (Prohormone convertase 1) (Proprotein convertase 1) (PC1) Pcsk1 Bdp Nec-1 Nec1 Rattus norvegicus (Rat) TR15490_c0_g1_i1 P97868 RBBP6_MOUSE 4.00E-29 GO:0005694; GO:0005737; GO:0048568; GO:0001701; GO:0005815; GO:0035264; GO:0003676; GO:0005730; GO:0042787; GO:0061053; GO:0004842; GO:0008270 chromosome; cytoplasm; embryonic organ development; in utero embryonic development; microtubule organizing center; multicellular organism growth; nucleic acid binding; nucleolus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; somite development; ubiquitin-protein ligase activity; zinc ion binding IPR014891; IPR001878; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RBBP6 (EC 6.3.2.-) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) Rbbp6 P2pr Pact Mus musculus (Mouse) TR15491_c1_g1_i1 P51544 KARG_HALMK 1.00E-66 GO:0005524; GO:0004054 ATP binding; arginine kinase activity IPR022415; IPR022414; IPR022413; IPR014746; Arginine kinase (AK) (EC 2.7.3.3) Haliotis madaka (Giant abalone) (Nordotis madaka) TR15492_c0_g1_i1 Q9VUL9 FUCTA_DROME 6.00E-06 GO:0033932; GO:0032580; GO:0005797; GO:0036071; GO:0018392; GO:0016021; GO:0007399; GO:0006486 Q9VG62 "1,3-alpha-L-fucosidase activity; Golgi cisterna membrane; Golgi medial cisterna; N-glycan fucosylation; glycoprotein 3-alpha-L-fucosyltransferase activity; integral to membrane; nervous system development; protein glycosylation" IPR001503; Protein modification; protein glycosylation. "Glycoprotein 3-alpha-L-fucosyltransferase A (EC 2.4.1.214) (Core alpha-(1,3)-fucosyltransferase)" FucTA CG6869 Drosophila melanogaster (Fruit fly) TR15496_c1_g1_i1 Q2KHZ8 GLCM_BOVIN 4.00E-48 GO:0005975; GO:0004348; GO:0005765; GO:0006665 carbohydrate metabolic process; glucosylceramidase activity; lysosomal membrane; sphingolipid metabolic process IPR013780; IPR001139; IPR013781; IPR017853; Glucosylceramidase (EC 3.2.1.45) (Acid beta-glucosidase) (Beta-glucocerebrosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) GBA Bos taurus (Bovine) TR15504_c0_g1_i2 P22105 TENX_HUMAN 2.00E-09 GO:0030036; GO:0007155; GO:0016337; GO:0007160; GO:0030199; GO:0032963; GO:0048251; GO:0043206; GO:0005615; GO:0006631; GO:0008201; GO:0005178; GO:0005622; GO:0005578; GO:0043506; GO:0006641 actin cytoskeleton organization; cell adhesion; cell-cell adhesion; cell-matrix adhesion; collagen fibril organization; collagen metabolic process; elastic fiber assembly; extracellular fibril organization; extracellular space; fatty acid metabolic process; heparin binding; integrin binding; intracellular; proteinaceous extracellular matrix; regulation of JUN kinase activity; triglyceride metabolic process IPR000742; IPR013032; IPR014716; IPR014715; IPR002181; IPR020837; IPR003961; IPR013783; Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) TR15505_c1_g2_i1 A9ULZ2 BIR7B_XENLA 1.00E-07 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) TR15505_c1_g3_i1 Q6R7D0 IAP3_OSHVF 3.00E-08 IPR001370; Putative apoptosis inhibitor ORF99 ORF99 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) TR1551_c0_g1_i1 B5XGE7 TPC2L_SALSA 1.00E-75 GO:0006888; GO:0005794; GO:0005783; GO:0048471 ER to Golgi vesicle-mediated transport; Golgi apparatus; endoplasmic reticulum; perinuclear region of cytoplasm IPR011012; IPR006722; Trafficking protein particle complex subunit 2-like protein trappc2l tpc2l Salmo salar (Atlantic salmon) TR15511_c0_g1_i1 Q9UPU5 UBP24_HUMAN 2.00E-38 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR016024; IPR018200; IPR001394; IPR009060; IPR015940; Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) USP24 KIAA1057 Homo sapiens (Human) TR15521_c0_g1_i1 P46405 RS12_PIG 5.00E-42 GO:0022627; GO:0003735; GO:0006412 cytosolic small ribosomal subunit; structural constituent of ribosome; translation IPR004038; IPR000530; 40S ribosomal protein S12 RPS12 Sus scrofa (Pig) TR15523_c2_g1_i1 Q9VW71 FAT2_DROME 5.00E-08 GO:0009925; GO:0005509; GO:0016339; GO:0050839; GO:0050829; GO:0042247; GO:0030950; GO:0005925; GO:0007440; GO:0007295; GO:0007442; GO:0007156; GO:0005887; GO:0045571; GO:0007424; GO:0045089; GO:0004872; GO:0007431 basal plasma membrane; calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; defense response to Gram-negative bacterium; establishment of planar polarity of follicular epithelium; establishment or maintenance of actin cytoskeleton polarity; focal adhesion; foregut morphogenesis; growth of a germarium-derived egg chamber; hindgut morphogenesis; homophilic cell adhesion; integral to plasma membrane; negative regulation of imaginal disc growth; open tracheal system development; positive regulation of innate immune response; receptor activity; salivary gland development IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Fat-like cadherin-related tumor suppressor homolog (Protein kugelei) kug fat2 CG7749 Drosophila melanogaster (Fruit fly) TR15526_c0_g2_i1 Q9U0E6 PROF_SUBDO 5.00E-38 GO:0030036 actin cytoskeleton organization IPR027310; IPR005455; Profilin Suberites domuncula (Sponge) TR15527_c2_g1_i1 Q7LHG5 YI31B_YEAST 3.00E-06 GO:0005524; GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0005737; GO:0008233; GO:0006508; GO:0000943; GO:0004523; GO:0004540; GO:0032197; GO:0046797; GO:0008270 "ATP binding; DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; cytoplasm; peptidase activity; proteolysis; retrotransposon nucleocapsid; ribonuclease H activity; ribonuclease activity; transposition, RNA-mediated; viral procapsid maturation; zinc ion binding" IPR001584; IPR024650; IPR021109; IPR005162; IPR012337; IPR000477; IPR001878; Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR15533_c0_g1_i1 Q16566 KCC4_HUMAN 1.00E-18 GO:0005524; GO:0007202; GO:0004683; GO:0005829; GO:0007173; GO:0008543; GO:0006954; GO:0045087; GO:0007616; GO:0043011; GO:0007270; GO:0048011; GO:0006913; GO:0005730; GO:0005654; GO:0046827; GO:0045893; GO:0006468; GO:0033081; GO:0045670; GO:0007268 "ATP binding; activation of phospholipase C activity; calmodulin-dependent protein kinase activity; cytosol; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; inflammatory response; innate immune response; long-term memory; myeloid dendritic cell differentiation; neuron-neuron synaptic transmission; neurotrophin TRK receptor signaling pathway; nucleocytoplasmic transport; nucleolus; nucleoplasm; positive regulation of protein export from nucleus; positive regulation of transcription, DNA-dependent; protein phosphorylation; regulation of T cell differentiation in thymus; regulation of osteoclast differentiation; synaptic transmission" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) CAMK4 CAMK CAMK-GR CAMKIV Homo sapiens (Human) TR15537_c0_g1_i2 A9JTP3 BIRC7_XENTR 4.00E-21 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP) (Embryonic/Egg IAP) (EIAP/XLX) birc7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR15537_c0_g1_i3 Q8JHV9 BIR7A_XENLA 2.00E-19 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR15541_c1_g1_i1 P08953 TOLL_DROME 6.00E-18 GO:0033565; GO:0008063; GO:0019732; GO:0007155; GO:0019955; GO:0050830; GO:0005769; GO:0009897; GO:0007507; GO:0035172; GO:0030097; GO:0045087; GO:0016021; GO:0006963; GO:0006967; GO:0045610; GO:0007416; GO:0016201; GO:0004888; GO:0007352 Itself; Q7K105 ESCRT-0 complex; Toll signaling pathway; antifungal humoral response; cell adhesion; cytokine binding; defense response to Gram-positive bacterium; early endosome; external side of plasma membrane; heart development; hemocyte proliferation; hemopoiesis; innate immune response; integral to membrane; positive regulation of antibacterial peptide biosynthetic process; positive regulation of antifungal peptide biosynthetic process; regulation of hemocyte differentiation; synapse assembly; synaptic target inhibition; transmembrane signaling receptor activity; zygotic specification of dorsal/ventral axis IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) TR15543_c0_g1_i1 Q8C8H8 KY_MOUSE 4.00E-08 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) TR15546_c3_g1_i1 Q9H611 PIF1_HUMAN 5.00E-13 GO:0005524; GO:0043141; GO:0033682; GO:0006310; GO:0006281; GO:0000287; GO:0005739; GO:0051974; GO:0000784; GO:0032204; GO:0017116; GO:0000723; GO:0042162 "ATP binding; ATP-dependent 5'-3' DNA helicase activity; ATP-dependent 5'-3' DNA/RNA helicase activity; DNA recombination; DNA repair; magnesium ion binding; mitochondrion; negative regulation of telomerase activity; nuclear chromosome, telomeric region; regulation of telomere maintenance; single-stranded DNA-dependent ATP-dependent DNA helicase activity; telomere maintenance; telomeric DNA binding" IPR003840; IPR010285; IPR027417; ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (DNA repair and recombination helicase PIF1) (PIF1/RRM3 DNA helicase-like protein) PIF1 C15orf20 Homo sapiens (Human) TR15547_c1_g1_i1 Q8MJC3 CASP3_RABIT 1.00E-24 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Oryctolagus cuniculus (Rabbit) TR15559_c1_g1_i1 Q05654 RTF21_SCHPO 2.00E-06 TR15559_c2_g1_i1 Q5DTZ0 NYNRI_MOUSE 3.00E-07 GO:0015074; GO:0016021; GO:0003676 DNA integration; integral to membrane; nucleic acid binding IPR001584; IPR021869; IPR012337; Protein NYNRIN (NYN domain and retroviral integrase catalytic domain-containing protein) (Pol-like protein) Nynrin Kiaa1305 Mus musculus (Mouse) TR15560_c0_g1_i1 Q8VHI7 CCD65_MOUSE 1.00E-18 Coiled-coil domain-containing protein 65 (Testis development protein NYD-SP28) Ccdc65 Mus musculus (Mouse) TR15564_c1_g1_i1 Q00492 SUM1_LYTVA 5.00E-43 GO:0003677; GO:0007517; GO:0005634; GO:0006355; GO:0006351 "DNA binding; muscle organ development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002546; IPR011598; IPR022032; Transcription factor SUM-1 (Sea urchin myogenic factor 1) SUM-1 Lytechinus variegatus (Green sea urchin) (Variegated urchin) TR15570_c1_g1_i1 Q2PZL6 FAT4_MOUSE 3.00E-21 GO:0045177; GO:0001658; GO:0005509; GO:0048565; GO:0001736; GO:0003007; GO:0007156; GO:0060122; GO:0016021; GO:0001822; GO:0043931; GO:0005886; GO:0007009 apical part of cell; branching involved in ureteric bud morphogenesis; calcium ion binding; digestive tract development; establishment of planar polarity; heart morphogenesis; homophilic cell adhesion; inner ear receptor stereocilium organization; integral to membrane; kidney development; ossification involved in bone maturation; plasma membrane; plasma membrane organization IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) Fat4 Fatj Mus musculus (Mouse) TR15582_c0_g1_i1 Q5ZID0 NMRL1_CHICK 6.00E-37 GO:0005730; GO:0048471 nucleolus; perinuclear region of cytoplasm IPR016040; IPR008030; NmrA-like family domain-containing protein 1 NMRAL1 RCJMB04_27o15 Gallus gallus (Chicken) TR15589_c0_g1_i1 Q4PMB3 RS4_IXOSC 9.00E-150 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR005824; IPR000876; IPR013845; IPR013843; IPR018199; IPR002942; 40S ribosomal protein S4 RpS4 Ixodes scapularis (Black-legged tick) (Deer tick) TR15590_c0_g1_i1 Q9H251 CAD23_HUMAN 7.00E-08 GO:0005509; GO:0006816; GO:0016339; GO:0051480; GO:0050957; GO:0007156; GO:0016021; GO:0016020; GO:0045494; GO:0005886; GO:0050896; GO:0050953; GO:0007605; GO:0032420; GO:0007601 calcium ion binding; calcium ion transport; calcium-dependent cell-cell adhesion; cytosolic calcium ion homeostasis; equilibrioception; homophilic cell adhesion; integral to membrane; membrane; photoreceptor cell maintenance; plasma membrane; response to stimulus; sensory perception of light stimulus; sensory perception of sound; stereocilium; visual perception IPR002126; IPR015919; IPR020894; Cadherin-23 (Otocadherin) CDH23 KIAA1774 KIAA1812 UNQ1894/PRO4340 Homo sapiens (Human) TR15595_c1_g1_i1 Q9BQT8 ODC_HUMAN 9.00E-47 GO:0034641; GO:0016021; GO:0006554; GO:0005743; GO:0055085 cellular nitrogen compound metabolic process; integral to membrane; lysine catabolic process; mitochondrial inner membrane; transmembrane transport IPR002067; IPR018108; IPR023395; Mitochondrial 2-oxodicarboxylate carrier (Solute carrier family 25 member 21) SLC25A21 ODC Homo sapiens (Human) TR15596_c1_g1_i1 Q80WN8 B4GT3_CRIGR 4.00E-19 GO:0032580; GO:0003945; GO:0003831; GO:0016021; GO:0046872; GO:0006486 "Golgi cisterna membrane; N-acetyllactosamine synthase activity; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; integral to membrane; metal ion binding; protein glycosylation" IPR003859; IPR027791; IPR027995; Protein modification; protein glycosylation. "Beta-1,4-galactosyltransferase 3 (Beta-1,4-GalTase 3) (Beta4Gal-T3) (b4Gal-T3) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3) [Includes: N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthase); Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)]" B4GALT3 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR15599_c1_g2_i1 P56719 OX2R_RAT 7.00E-14 GO:0022410; GO:0007631; GO:0016021; GO:0007218; GO:0016499; GO:0017046; GO:0007200; GO:0005886 circadian sleep/wake cycle process; feeding behavior; integral to membrane; neuropeptide signaling pathway; orexin receptor activity; peptide hormone binding; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane IPR000276; IPR017452; IPR000204; IPR004060; Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Rattus norvegicus (Rat) TR1560_c0_g1_i1 Q5R6B1 LRRT1_PONAB 2.00E-06 GO:0030054; GO:0016021; GO:0045211 cell junction; integral to membrane; postsynaptic membrane IPR001611; IPR003591; IPR000372; Leucine-rich repeat transmembrane neuronal protein 1 LRRTM1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR15602_c0_g1_i1 Q9QXW9 LAT2_MOUSE 6.00E-15 GO:0015179; GO:0005275; GO:0016323; GO:0005737; GO:0016021; GO:0015101; GO:0005886; GO:0019534 L-amino acid transmembrane transporter activity; amine transmembrane transporter activity; basolateral plasma membrane; cytoplasm; integral to membrane; organic cation transmembrane transporter activity; plasma membrane; toxin transporter activity IPR002293; IPR004760; Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (mLAT2) (Solute carrier family 7 member 8) Slc7a8 Lat2 Mus musculus (Mouse) TR15603_c1_g1_i1 O15050 TRNK1_HUMAN 1.00E-11 GO:0005524; GO:0016787 ATP binding; hydrolase activity IPR002110; IPR020683; IPR014017; IPR027417; IPR013026; IPR011990; IPR014016; TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) TR15620_c0_g1_i1 P52505 ACPM_BOVIN 5.00E-36 GO:0008137; GO:0005504; GO:0006633; GO:0006120; GO:0005759; GO:0005747 "NADH dehydrogenase (ubiquinone) activity; fatty acid binding; fatty acid biosynthetic process; mitochondrial electron transport, NADH to ubiquinone; mitochondrial matrix; mitochondrial respiratory chain complex I" IPR003231; IPR009081; IPR006162; "Acyl carrier protein, mitochondrial (ACP) (CI-SDAP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit)" NDUFAB1 Bos taurus (Bovine) TR15627_c1_g1_i1 P02549 SPTA1_HUMAN 2.00E-31 GO:0051015; GO:0051693; GO:0007015; GO:0007411; GO:0005509; GO:0032437; GO:0005829; GO:0030097; GO:0031235; GO:0002260; GO:0007009; GO:0006779; GO:0042102; GO:0032092; GO:0008360; GO:0008091; GO:0014731; GO:0005200 Q8IZP0; Q01082 actin filament binding; actin filament capping; actin filament organization; axon guidance; calcium ion binding; cuticular plate; cytosol; hemopoiesis; intrinsic to internal side of plasma membrane; lymphocyte homeostasis; plasma membrane organization; porphyrin-containing compound biosynthetic process; positive regulation of T cell proliferation; positive regulation of protein binding; regulation of cell shape; spectrin; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR011992; IPR014837; IPR002048; IPR001452; IPR018159; IPR013315; IPR002017; "Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin)" SPTA1 SPTA Homo sapiens (Human) TR15627_c2_g1_i1 P13395 SPTCA_DROME 5.00E-48 GO:0005794; GO:0003779; GO:0051693; GO:0016199; GO:0016323; GO:0005509; GO:0007417; GO:0045169; GO:0045478; GO:0030727; GO:0007294; GO:0005811; GO:0042062; GO:0048790; GO:0008017; GO:0007026; GO:0031594; GO:0007274; GO:0007308; GO:0030707; GO:0007009; GO:0008360; GO:0008091; GO:0045170; GO:0030721 Golgi apparatus; actin binding; actin filament capping; axon midline choice point recognition; basolateral plasma membrane; calcium ion binding; central nervous system development; fusome; fusome organization; germarium-derived female germ-line cyst formation; germarium-derived oocyte fate determination; lipid particle; long-term strengthening of neuromuscular junction; maintenance of presynaptic active zone structure; microtubule binding; negative regulation of microtubule depolymerization; neuromuscular junction; neuromuscular synaptic transmission; oocyte construction; ovarian follicle cell development; plasma membrane organization; regulation of cell shape; spectrin; spectrosome; spectrosome organization IPR011992; IPR014837; IPR018247; IPR002048; IPR001452; IPR018159; IPR013315; IPR002017; Spectrin alpha chain alpha-Spec SPEC-A CG1977 Drosophila melanogaster (Fruit fly) TR15628_c0_g2_i2 Q8WZ42 TITIN_HUMAN 3.00E-06 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR15634_c0_g1_i1 Q5VU97 CAHD1_HUMAN 1.00E-94 GO:0006816; GO:0016021 calcium ion transport; integral to membrane IPR004010; IPR013608; IPR002035; VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) CACHD1 KIAA1573 VWCD1 Homo sapiens (Human) TR15636_c0_g1_i1 Q9J5I3 V018_FOWPN 1.00E-09 IPR002110; IPR020683; IPR018272; Putative ankyrin repeat protein FPV018 FPV018 Fowlpox virus (strain NVSL) (FPV) TR15636_c0_g2_i1 Q5UPG5 YL093_MIMIV 5.00E-16 IPR002110; IPR020683; Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) TR15640_c0_g1_i1 Q9XWD6 CED1_CAEEL 2.00E-27 GO:0031532; GO:0006915; GO:0009986; GO:0034620; GO:0042742; GO:0043652; GO:0045184; GO:0016021; GO:0001891; GO:0030670; GO:0001845; GO:0012501; GO:0031260; GO:0043654; GO:0005044 actin cytoskeleton reorganization; apoptotic process; cell surface; cellular response to unfolded protein; defense response to bacterium; engulfment of apoptotic cell; establishment of protein localization; integral to membrane; phagocytic cup; phagocytic vesicle membrane; phagolysosome assembly; programmed cell death; pseudopodium membrane; recognition of apoptotic cell; scavenger receptor activity IPR000742; IPR013032; IPR002049; IPR011489; IPR006212; Cell death abnormality protein 1 ced-1 Y47H9C.4 Caenorhabditis elegans TR15648_c0_g1_i1 Q6DRF9 WDR55_DANRE 1.00E-94 GO:0001654; GO:0005730; GO:0060465; GO:0006364; GO:0048794; GO:0048538 eye development; nucleolus; pharynx development; rRNA processing; swim bladder development; thymus development IPR015943; IPR001680; IPR019775; IPR017986; IPR017422; WD repeat-containing protein 55 wdr55 Danio rerio (Zebrafish) (Brachydanio rerio) TR15658_c0_g1_i1 Q8N8V4 ANS4B_HUMAN 5.00E-09 GO:0005886 plasma membrane IPR002110; IPR020683; IPR001660; IPR013761; IPR021129; Ankyrin repeat and SAM domain-containing protein 4B (Harmonin-interacting ankyrin repeat-containing protein) (Harp) ANKS4B HARP Homo sapiens (Human) TR15659_c1_g1_i1 Q69Z23 DYH17_MOUSE 4.00E-67 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 17, axonemal (Axonemal beta dynein heavy chain 17) (Ciliary dynein heavy chain 17)" Dnah17 Dnahc17 Kiaa3028 Mus musculus (Mouse) TR15660_c2_g1_i1 Q6P698 PLSL_DANRE 2.00E-16 GO:0005509; GO:0005737 calcium ion binding; cytoplasm IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; Plastin-2 (L-plastin) (Lymphocyte cytosolic plastin 1) lcp1 pls2 Danio rerio (Zebrafish) (Brachydanio rerio) TR15671_c1_g1_i1 Q05688 IGF1R_BOVIN 5.00E-40 GO:0005524; GO:0006955; GO:0051389; GO:0043559; GO:0043560; GO:0005520; GO:0005010; GO:0016021; GO:0043231; GO:0043066; GO:0043548; GO:0048015; GO:0045740; GO:0030335; GO:0046777; GO:0051262; GO:0046328 ATP binding; immune response; inactivation of MAPKK activity; insulin binding; insulin receptor substrate binding; insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; integral to membrane; intracellular membrane-bounded organelle; negative regulation of apoptotic process; phosphatidylinositol 3-kinase binding; phosphatidylinositol-mediated signaling; positive regulation of DNA replication; positive regulation of cell migration; protein autophosphorylation; protein tetramerization; regulation of JNK cascade IPR003961; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR002011; Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (Fragment) IGF1R Bos taurus (Bovine) TR15671_c1_g2_i1 P00529 ROS_AVISU 2.00E-27 GO:0005524; GO:0016020; GO:0018108; GO:0004714; GO:0007169 ATP binding; membrane; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR002011; Tyrosine-protein kinase transforming protein ros (EC 2.7.10.1) V-ROS UR2 sarcoma virus (UR2SV) (Avian sarcoma virus (strain UR2)) TR15671_c2_g1_i1 Q5XJV6 LMTK3_MOUSE 4.00E-09 GO:0005524; GO:0030424; GO:0030425; GO:0016021; GO:0010923; GO:0018108; GO:0004674; GO:0004713 ATP binding; axon; dendrite; integral to membrane; negative regulation of phosphatase activity; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; Serine/threonine-protein kinase LMTK3 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 3) (Lemur tyrosine kinase 3) Lmtk3 Aatyk3 Mus musculus (Mouse) TR15672_c0_g1_i1 Q9JLC8 SACS_MOUSE 1.00E-08 GO:0005524; GO:0050750; GO:0005739; GO:0090084; GO:0005634 ATP binding; low-density lipoprotein particle receptor binding; mitochondrion; negative regulation of inclusion body assembly; nucleus IPR001623; IPR003594; IPR007842; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) TR15677_c3_g1_i1 Q3U288 ZN710_MOUSE 3.00E-14 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 710 Znf710 Zfp710 Mus musculus (Mouse) TR15678_c0_g1_i1 Q56K04 CRIP1_BOVIN 7.00E-18 GO:0003680; GO:0008301; GO:0071493; GO:0071236; GO:0005737; GO:0008630; GO:0042277; GO:0010043; GO:0008270 "AT DNA binding; DNA binding, bending; cellular response to UV-B; cellular response to antibiotic; cytoplasm; intrinsic apoptotic signaling pathway in response to DNA damage; peptide binding; response to zinc ion; zinc ion binding" IPR001781; Cysteine-rich protein 1 (CRP-1) CRIP1 Bos taurus (Bovine) TR15689_c0_g1_i1 Q06806 TIE1_MOUSE 4.00E-11 GO:0005524; GO:0001525; GO:0001701; GO:0016021; GO:0016525; GO:0030336; GO:0018108; GO:0005886; GO:0045026; GO:0032526; GO:0004714 ATP binding; angiogenesis; in utero embryonic development; integral to membrane; negative regulation of angiogenesis; negative regulation of cell migration; peptidyl-tyrosine phosphorylation; plasma membrane; plasma membrane fusion; response to retinoic acid; transmembrane receptor protein tyrosine kinase activity IPR000742; IPR013032; IPR003961; IPR007110; IPR013783; IPR003599; IPR013151; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) Tie1 Tie Tie-1 Mus musculus (Mouse) TR15689_c0_g2_i1 Q80V70 MEGF6_MOUSE 5.00E-10 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR013111; IPR002049; IPR011489; IPR009030; Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) TR157_c1_g1_i1 P51544 KARG_HALMK 3.00E-39 GO:0005524; GO:0004054 ATP binding; arginine kinase activity IPR022415; IPR022414; IPR022413; IPR014746; Arginine kinase (AK) (EC 2.7.3.3) Haliotis madaka (Giant abalone) (Nordotis madaka) TR15701_c0_g1_i1 Q17RB8 LONF1_HUMAN 3.00E-106 GO:0004176; GO:0006508; GO:0008270 ATP-dependent peptidase activity; proteolysis; zinc ion binding IPR003111; IPR015947; IPR013026; IPR011990; IPR013105; IPR019734; IPR001841; IPR013083; IPR017907; LON peptidase N-terminal domain and RING finger protein 1 (RING finger protein 191) LONRF1 RNF191 Homo sapiens (Human) TR15701_c2_g1_i1 P25407 STI1L_PLAFA 9.00E-18 IPR013026; IPR011990; IPR001440; IPR019734; STI1-like protein (Fragment) Plasmodium falciparum TR15703_c1_g1_i1 Q6ZT12 UBR3_HUMAN 2.00E-32 GO:0009790; GO:0001701; GO:0016021; GO:0042048; GO:0007608; GO:0001967; GO:0006511; GO:0004842; GO:0008270 embryo development; in utero embryonic development; integral to membrane; olfactory behavior; sensory perception of smell; suckling behavior; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR003126; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UBR3 (EC 6.3.2.-) (N-recognin-3) (Ubiquitin-protein ligase E3-alpha-3) (Ubiquitin-protein ligase E3-alpha-III) (Zinc finger protein 650) UBR3 KIAA2024 ZNF650 Homo sapiens (Human) TR15704_c0_g1_i1 P09208 INSR_DROME 5.00E-11 GO:0005524; GO:0051425; GO:0042169; GO:0007411; GO:0005911; GO:0007623; GO:0008340; GO:0007391; GO:0048132; GO:0008585; GO:0060180; GO:0007390; GO:0060250; GO:0007446; GO:0043559; GO:0005899; GO:0043560; GO:0005009; GO:0007626; GO:0048133; GO:0046872; GO:0010507; GO:0043548; GO:0030307; GO:0008284; GO:0045793; GO:0040018; GO:0046622; GO:0007285; GO:0046777; GO:0051290; GO:2000377; GO:0006974; GO:0034059; GO:0042220; GO:0007584; GO:0006979; GO:0007296 Itself; Q9XTN2 ATP binding; PTB domain binding; SH2 domain binding; axon guidance; cell-cell junction; circadian rhythm; determination of adult lifespan; dorsal closure; female germ-line stem cell division; female gonad development; female mating behavior; germ-band shortening; germ-line stem-cell niche homeostasis; imaginal disc growth; insulin binding; insulin receptor complex; insulin receptor substrate binding; insulin-activated receptor activity; locomotory behavior; male germ-line stem cell division; metal ion binding; negative regulation of autophagy; phosphatidylinositol 3-kinase binding; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cell size; positive regulation of multicellular organism growth; positive regulation of organ growth; primary spermatocyte growth; protein autophosphorylation; protein heterotetramerization; regulation of reactive oxygen species metabolic process; response to DNA damage stimulus; response to anoxia; response to cocaine; response to nutrient; response to oxidative stress; vitellogenesis IPR000494; IPR003961; IPR006211; IPR006212; IPR009030; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR002011; Insulin-like receptor (dIR) (dInr) (EC 2.7.10.1) (dIRH) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1; Insulin-like receptor subunit beta 2] InR dinr Dir-a Inr-a CG18402 Drosophila melanogaster (Fruit fly) TR15705_c0_g1_i1 O22348 TBA2_ELEIN 2.00E-15 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR013838; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-2 chain (Alpha-2-tubulin) TUBA2 TUA2 Eleusine indica (Goosegrass) (Cynosurus indicus) TR15706_c0_g1_i1 P84675 PFM_CHAGB 2.00E-10 GO:0050832; GO:0031640 defense response to fungus; killing of cells of other organism IPR002889; IPR013994; Putative fungistatic metabolite CHGG_05463 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) TR15707_c0_g1_i1 P15621 ZNF44_HUMAN 3.00E-42 GO:0003677; GO:0005737; GO:0046872; GO:0015630; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cytoplasm; metal ion binding; microtubule cytoskeleton; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 44 (Gonadotropin-inducible ovary transcription repressor 2) (GIOT-2) (Zinc finger protein 55) (Zinc finger protein 58) (Zinc finger protein KOX7) ZNF44 GIOT2 KOX7 ZNF55 ZNF58 Homo sapiens (Human) TR15707_c1_g1_i1 Q14590 ZN235_HUMAN 9.00E-55 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) TR15723_c0_g2_i1 P58195 PLS1_RAT 3.00E-45 GO:0042609; GO:0003677; GO:0005794; GO:0001077; GO:0017124; GO:0006915; GO:0005509; GO:0005829; GO:0051607; GO:0005154; GO:0031012; GO:0006955; GO:0005887; GO:0045121; GO:0045071; GO:0005730; GO:0017128; GO:2000373; GO:0045089; GO:0060368; GO:0033003 CD4 receptor binding; DNA binding; Golgi apparatus; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; SH3 domain binding; apoptotic process; calcium ion binding; cytosol; defense response to virus; epidermal growth factor receptor binding; extracellular matrix; immune response; integral to plasma membrane; membrane raft; negative regulation of viral genome replication; nucleolus; phospholipid scramblase activity; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity; positive regulation of innate immune response; regulation of Fc receptor mediated stimulatory signaling pathway; regulation of mast cell activation IPR005552; Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) Plscr1 Rattus norvegicus (Rat) TR15726_c0_g1_i1 O43763 TLX2_HUMAN 6.00E-16 GO:0005737; GO:0048484; GO:0001707; GO:0050774; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "cytoplasm; enteric nervous system development; mesoderm formation; negative regulation of dendrite morphogenesis; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR020479; IPR009057; T-cell leukemia homeobox protein 2 (Homeobox protein Hox-11L1) (Neural crest homeobox protein) TLX2 HOX11L1 NCX Homo sapiens (Human) TR15726_c0_g2_i1 Q2PYN8 LBX1_XENLA 5.00E-48 GO:0030154; GO:0007517; GO:0051450; GO:0000122; GO:0005634; GO:0003700; GO:0005667; GO:0000976; GO:0006351 "cell differentiation; muscle organ development; myoblast proliferation; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription regulatory region sequence-specific DNA binding; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; IPR000047; Transcription factor LBX1 (Ladybird homeobox protein homolog 1) lbx1 Xenopus laevis (African clawed frog) TR15727_c0_g1_i1 Q86VH2 KIF27_HUMAN 2.00E-15 GO:0005524; GO:0005929; GO:0042384; GO:0005737; GO:0003351; GO:0005871; GO:0005874; GO:0003777; GO:0021591 ATP binding; cilium; cilium assembly; cytoplasm; epithelial cilium movement; kinesin complex; microtubule; microtubule motor activity; ventricular system development IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF27 KIF27 Homo sapiens (Human) TR15730_c0_g1_i1 D3Z7P3 GLSK_MOUSE 2.00E-08 GO:0005829; GO:0006537; GO:0004359; GO:0006543; GO:0005739; GO:0051289; GO:0002087; GO:0001967; GO:0007268 cytosol; glutamate biosynthetic process; glutaminase activity; glutamine catabolic process; mitochondrion; protein homotetramerization; regulation of respiratory gaseous exchange by neurological system process; suckling behavior; synaptic transmission IPR002110; IPR020683; IPR012338; IPR015868; "Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2)" Gls Gls1 Kiaa0838 Mus musculus (Mouse) TR15731_c0_g1_i1 Q6UPE0 CHDH_RAT 7.00E-31 GO:0008812; GO:0050660; GO:0019285; GO:0005743 choline dehydrogenase activity; flavin adenine dinucleotide binding; glycine betaine biosynthetic process from choline; mitochondrial inner membrane IPR012132; IPR000172; IPR007867; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. "Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)" Chdh Rattus norvegicus (Rat) TR15732_c1_g1_i1 Q5F389 WWOX_CHICK 1.00E-16 GO:0016055; GO:0006915; GO:0005737; GO:0005634; GO:0016491 Wnt receptor signaling pathway; apoptotic process; cytoplasm; nucleus; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR001202; WW domain-containing oxidoreductase (EC 1.1.1.-) WWOX RCJMB04_28b1 Gallus gallus (Chicken) TR15732_c1_g2_i1 Q0IH28 DRS7B_XENLA 2.00E-06 GO:0016021; GO:0016491; GO:0005778 integral to membrane; oxidoreductase activity; peroxisomal membrane IPR002198; IPR002347; IPR016040; IPR020904; Dehydrogenase/reductase SDR family member 7B (EC 1.1.-.-) dhrs7b Xenopus laevis (African clawed frog) TR15736_c0_g1_i1 P33431 SODC_CAVPO 2.00E-43 GO:0000187; GO:0008089; GO:0006309; GO:0060088; GO:0007569; GO:0006879; GO:0051087; GO:0005507; GO:0031410; GO:0005829; GO:0032839; GO:0006302; GO:0007566; GO:0031012; GO:0005615; GO:0006749; GO:0060047; GO:0050665; GO:0007626; GO:0005739; GO:0046716; GO:0002262; GO:0045541; GO:0043524; GO:0060052; GO:0043025; GO:0005634; GO:0001541; GO:0032287; GO:0005886; GO:0001819; GO:1902177; GO:0032930; GO:0043234; GO:0030346; GO:0032314; GO:0008217; GO:0051881; GO:0040014; GO:0060087; GO:0019430; GO:0048678; GO:0042493; GO:0045471; GO:0009408; GO:0042542; GO:0001895; GO:0008090; GO:0007605; GO:0007283; GO:0042554; GO:0004784; GO:0008270 activation of MAPK activity; anterograde axon cargo transport; apoptotic DNA fragmentation; auditory receptor cell stereocilium organization; cell aging; cellular iron ion homeostasis; chaperone binding; copper ion binding; cytoplasmic vesicle; cytosol; dendrite cytoplasm; double-strand break repair; embryo implantation; extracellular matrix; extracellular space; glutathione metabolic process; heart contraction; hydrogen peroxide biosynthetic process; locomotory behavior; mitochondrion; muscle cell cellular homeostasis; myeloid cell homeostasis; negative regulation of cholesterol biosynthetic process; negative regulation of neuron apoptotic process; neurofilament cytoskeleton organization; neuronal cell body; nucleus; ovarian follicle development; peripheral nervous system myelin maintenance; plasma membrane; positive regulation of cytokine production; positive regulation of intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of superoxide anion generation; protein complex; protein phosphatase 2B binding; regulation of Rac GTPase activity; regulation of blood pressure; regulation of mitochondrial membrane potential; regulation of multicellular organism growth; relaxation of vascular smooth muscle; removal of superoxide radicals; response to axon injury; response to drug; response to ethanol; response to heat; response to hydrogen peroxide; retina homeostasis; retrograde axon cargo transport; sensory perception of sound; spermatogenesis; superoxide anion generation; superoxide dismutase activity; zinc ion binding IPR024134; IPR018152; IPR001424; Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) SOD1 Cavia porcellus (Guinea pig) TR15741_c0_g1_i1 Q8J0I9 GUN16_TRIHA 7.00E-06 GO:0005576; GO:0005615; GO:0046557; GO:0004348; GO:0016798; GO:0005976; GO:0006665 "extracellular region; extracellular space; glucan endo-1,6-beta-glucosidase activity; glucosylceramidase activity; hydrolase activity, acting on glycosyl bonds; polysaccharide metabolic process; sphingolipid metabolic process" IPR013780; IPR001139; IPR013781; IPR017853; "Endo-1,6-beta-D-glucanase BGN16.3 (EC 3.2.1.75) (Beta-1,6-glucanase BGN16.3) (Glucan endo-1,6-beta-glucosidase BGN16.3)" Trichoderma harzianum (Hypocrea lixii) TR15744_c0_g1_i1 Q20719 NDUV2_CAEEL 3.00E-64 GO:0051537; GO:0008137; GO:0046872; GO:0006120; GO:0005747 "2 iron, 2 sulfur cluster binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I" IPR002023; IPR012336; "Probable NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3)" F53F4.10 Caenorhabditis elegans TR15750_c0_g1_i1 Q3TUF7 YETS2_MOUSE 4.00E-09 GO:0005671; GO:0043966; GO:0072686; GO:0000122; GO:0005634 Ada2/Gcn5/Ada3 transcription activator complex; histone H3 acetylation; mitotic spindle; negative regulation of transcription from RNA polymerase II promoter; nucleus IPR005033; YEATS domain-containing protein 2 Yeats2 Kiaa1197 Mus musculus (Mouse) TR15758_c0_g1_i1 Q5UR02 CHLE_MIMIV 4.00E-16 GO:0004091; GO:0004104 carboxylesterase activity; cholinesterase activity IPR002018; IPR019826; IPR019819; Probable cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) MIMI_L906 Acanthamoeba polyphaga mimivirus (APMV) TR15758_c1_g1_i1 P23654 NRT_DROME 7.00E-33 GO:0007411; GO:0007413; GO:0016323; GO:0004091; GO:0007155; GO:0007417; GO:0016021 axon guidance; axonal fasciculation; basolateral plasma membrane; carboxylesterase activity; cell adhesion; central nervous system development; integral to membrane IPR002018; IPR019819; Neurotactin Nrt CG9704 Drosophila melanogaster (Fruit fly) TR15767_c0_g1_i1 Q9UMX9 S45A2_HUMAN 8.00E-11 GO:0048066; GO:0016021; GO:0042438; GO:0033162; GO:0050896; GO:0007601 developmental pigmentation; integral to membrane; melanin biosynthetic process; melanosome membrane; response to stimulus; visual perception IPR016196; Membrane-associated transporter protein (Melanoma antigen AIM1) (Protein AIM-1) (Solute carrier family 45 member 2) SLC45A2 AIM1 MATP Homo sapiens (Human) TR15767_c2_g1_i1 Q9FE59 SUC4_ARATH 3.00E-09 GO:0005801; GO:0005887; GO:0005886; GO:0005985; GO:0008515; GO:0015293; GO:0005773 cis-Golgi network; integral to plasma membrane; plasma membrane; sucrose metabolic process; sucrose transmembrane transporter activity; symporter activity; vacuole IPR016196; IPR005989; Glycan biosynthesis; sucrose metabolism. Sucrose transport protein SUC4 (Sucrose permease 4) (Sucrose transporter 4) (Sucrose-proton symporter 4) SUC4 SUT4 At1g09960 F21M12.35 Arabidopsis thaliana (Mouse-ear cress) TR15767_c3_g1_i1 Q8K0H7 S45A3_MOUSE 5.00E-09 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR016196; Solute carrier family 45 member 3 (Prostate cancer-associated protein 6) (Prostein) Slc45a3 Pcanap6 Prst Mus musculus (Mouse) TR15772_c0_g1_i1 O82330 SOT10_ARATH 1.00E-06 GO:0016131; GO:0080118; GO:0005737; GO:0009735 brassinosteroid metabolic process; brassinosteroid sulfotransferase activity; cytoplasm; response to cytokinin stimulus IPR027417; IPR000863; Cytosolic sulfotransferase 10 (AtSOT10) (EC 2.8.2.-) (Sulfotransferase 4a) (AtST4a) SOT10 ST4A At2g14920 T26I20 Arabidopsis thaliana (Mouse-ear cress) TR15772_c1_g3_i1 Q7T2V2 ST1S3_DANRE 1.00E-11 GO:0006584; GO:0005737; GO:0008202; GO:0008146; GO:0006805 catecholamine metabolic process; cytoplasm; steroid metabolic process; sulfotransferase activity; xenobiotic metabolic process IPR027417; IPR000863; Cytosolic sulfotransferase 3 (EC 2.8.2.-) (SULT1 ST3) sult1st3 Danio rerio (Zebrafish) (Brachydanio rerio) TR15772_c1_g4_i1 Q9WUW9 S1C2A_RAT 2.00E-17 GO:0005764; GO:0008146 lysosome; sulfotransferase activity IPR027417; IPR000863; Sulfotransferase 1C2A (ST1C2A) (rSULT1C2A) (EC 2.8.2.-) (Sulfotransferase K2) Sult1c2a Sultk2 Rattus norvegicus (Rat) TR15778_c0_g1_i1 Q8HXW4 PYGM_MACFA 8.00E-44 GO:0005977; GO:0008184; GO:0000166; GO:0030170 glycogen metabolic process; glycogen phosphorylase activity; nucleotide binding; pyridoxal phosphate binding IPR011833; IPR000811; "Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase)" PYGM QccE-10224 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR15781_c0_g1_i1 Q92963 RIT1_HUMAN 6.00E-10 GO:0005525; GO:0003924; GO:0007265; GO:0005516; GO:0048011; GO:0005886 Q13129 GTP binding; GTPase activity; Ras protein signal transduction; calmodulin binding; neurotrophin TRK receptor signaling pathway; plasma membrane IPR027417; IPR005225; IPR001806; IPR020849; GTP-binding protein Rit1 (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1) RIT1 RIBB RIT ROC1 Homo sapiens (Human) TR15782_c0_g1_i1 Q22036 CAN5_CAEEL 2.00E-17 GO:0004198; GO:0030154; GO:0019099; GO:0042004; GO:0005622; GO:0016020; GO:0031293; GO:0016540; GO:0007548 calcium-dependent cysteine-type endopeptidase activity; cell differentiation; female germ-line sex determination; feminization of hermaphrodite soma; intracellular; membrane; membrane protein intracellular domain proteolysis; protein autoprocessing; sex differentiation IPR000008; IPR022684; IPR022682; IPR022683; IPR000169; IPR001300; Calpain-5 (EC 3.4.22.-) (Sex-determining transformer protein 3) tra-3 clp-5 LLC1.1 Caenorhabditis elegans TR15784_c0_g1_i1 Q6CPK7 KAPR_KLULA 5.00E-06 GO:0030552; GO:0005952; GO:0008603 cAMP binding; cAMP-dependent protein kinase complex; cAMP-dependent protein kinase regulator activity IPR002373; IPR012198; IPR003117; IPR018490; IPR018488; IPR000595; IPR014710; cAMP-dependent protein kinase regulatory subunit (PKA regulatory subunit) PKAR KLLA0E04070g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR15791_c0_g1_i1 Q5UPX0 YR290_MIMIV 1.00E-06 GO:0005524; GO:0043140; GO:0006310; GO:0006281; GO:0006260; GO:0003676 ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA recombination; DNA repair; DNA replication; nucleic acid binding IPR011545; IPR004589; IPR014001; IPR001650; IPR027417; IPR018982; IPR011991; Putative ATP-dependent RNA helicase R290 (EC 3.6.4.13) MIMI_R290 Acanthamoeba polyphaga mimivirus (APMV) TR15797_c1_g1_i1 P17972 KCNAW_DROME 2.00E-17 GO:0005251; GO:0051260; GO:0030431; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; sleep; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR015572; IPR003131; IPR028325; Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) TR1580_c0_g1_i1 Q8BPP0 ZN436_MOUSE 4.00E-16 GO:0003677; GO:0005737; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cytoplasm; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 436 (Zinc finger protein 46) (Zfp-46) (Zinc finger protein MLZ-4) Znf436 Kiaa1710 Mlz-4 Zfp46 Mus musculus (Mouse) TR15801_c0_g1_i1 Q9Y4D2 DGLA_HUMAN 5.00E-31 GO:0019369; GO:0008219; GO:0046340; GO:0071926; GO:0016021; GO:0046872; GO:0007405; GO:0042136; GO:0005886; GO:0030168; GO:0004806 arachidonic acid metabolic process; cell death; diacylglycerol catabolic process; endocannabinoid signaling pathway; integral to membrane; metal ion binding; neuroblast proliferation; neurotransmitter biosynthetic process; plasma membrane; platelet activation; triglyceride lipase activity IPR002921; Sn1-specific diacylglycerol lipase alpha (DGL-alpha) (EC 3.1.1.-) (Neural stem cell-derived dendrite regulator) DAGLA C11orf11 KIAA0659 NSDDR Homo sapiens (Human) TR15819_c0_g1_i1 Q47944 SDH_GLUOY 2.00E-06 GO:0006066; GO:0008812; GO:0050660 alcohol metabolic process; choline dehydrogenase activity; flavin adenine dinucleotide binding IPR012132; IPR000172; IPR007867; L-sorbose 1-dehydrogenase (SDH) (EC 1.1.99.32) Gluconobacter oxydans (Gluconobacter suboxydans) TR15828_c0_g2_i1 Q5JUQ0 FA78A_HUMAN 2.00E-77 Protein FAM78A FAM78A C9orf59 Homo sapiens (Human) TR15831_c1_g1_i1 Q8N895 ZN366_HUMAN 1.00E-24 GO:0003677; GO:0030331; GO:0046872; GO:0033147; GO:0000122; GO:0005634; GO:0043627; GO:0003714; GO:0006351 Q13363; P03372; P48552 "DNA binding; estrogen receptor binding; metal ion binding; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; response to estrogen stimulus; transcription corepressor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 366 ZNF366 Homo sapiens (Human) TR15832_c0_g1_i1 P23593 APOD_RAT 3.00E-13 GO:0007568; GO:0007420; GO:0015485; GO:0022626; GO:0030425; GO:0005783; GO:0005615; GO:0006006; GO:0006629; GO:2000405; GO:1900016; GO:0051895; GO:0060588; GO:0071638; GO:0010642; GO:0042308; GO:0048662; GO:2000098; GO:0043025; GO:0048471; GO:0014012; GO:0042493; GO:0000302; GO:0042246; GO:0005215 aging; brain development; cholesterol binding; cytosolic ribosome; dendrite; endoplasmic reticulum; extracellular space; glucose metabolic process; lipid metabolic process; negative regulation of T cell migration; negative regulation of cytokine production involved in inflammatory response; negative regulation of focal adhesion assembly; negative regulation of lipoprotein lipid oxidation; negative regulation of monocyte chemotactic protein-1 production; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein import into nucleus; negative regulation of smooth muscle cell proliferation; negative regulation of smooth muscle cell-matrix adhesion; neuronal cell body; perinuclear region of cytoplasm; peripheral nervous system axon regeneration; response to drug; response to reactive oxygen species; tissue regeneration; transporter activity IPR026222; IPR002969; IPR012674; IPR011038; IPR002345; IPR022271; IPR022272; IPR000566; Apolipoprotein D (Apo-D) (ApoD) Apod Rattus norvegicus (Rat) TR15833_c0_g1_i1 Q24292 DS_DROME 3.00E-17 GO:0005509; GO:0016339; GO:0050839; GO:0000904; GO:0008283; GO:0045317; GO:0045198; GO:0001737; GO:0007156; GO:0007480; GO:0005887; GO:0090176; GO:0016318; GO:0018149; GO:0004872; GO:0090175; GO:0035159; GO:0004871; GO:0035222 "calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; cell morphogenesis involved in differentiation; cell proliferation; equator specification; establishment of epithelial cell apical/basal polarity; establishment of imaginal disc-derived wing hair orientation; homophilic cell adhesion; imaginal disc-derived leg morphogenesis; integral to plasma membrane; microtubule cytoskeleton organization involved in establishment of planar polarity; ommatidial rotation; peptide cross-linking; receptor activity; regulation of establishment of planar polarity; regulation of tube length, open tracheal system; signal transducer activity; wing disc pattern formation" IPR002126; IPR015919; IPR020894; IPR000233; Protein dachsous (Adherin) ds CG17941 Drosophila melanogaster (Fruit fly) TR15833_c1_g1_i1 Q9VGW1 CAD86_DROME 3.00E-06 GO:0005509; GO:0016339; GO:0007156; GO:0005887; GO:0008360; GO:0035003 calcium ion binding; calcium-dependent cell-cell adhesion; homophilic cell adhesion; integral to plasma membrane; regulation of cell shape; subapical complex IPR002126; IPR015919; IPR020894; Cadherin-86C Cad86C CG4509 Drosophila melanogaster (Fruit fly) TR15836_c0_g1_i1 O94111 DYL1_EMENI 2.00E-13 GO:0030029; GO:0048315; GO:0005868; GO:0005874; GO:0003774; GO:0030473; GO:0005643; GO:0051292; GO:0005777; GO:0043935 actin filament-based process; conidium formation; cytoplasmic dynein complex; microtubule; motor activity; nuclear migration along microtubule; nuclear pore; nuclear pore complex assembly; peroxisome; sexual sporulation resulting in formation of a cellular spore IPR019763; IPR001372; "Dynein light chain, cytoplasmic (8 kDa cytoplasmic dynein light chain)" nudG AN0420 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR15840_c0_g1_i1 P35979 RL12_MOUSE 3.00E-36 GO:0003723; GO:0005840; GO:0003735; GO:0006412 RNA binding; ribosome; structural constituent of ribosome; translation IPR000911; IPR020783; IPR020785; IPR020784; 60S ribosomal protein L12 Rpl12 Mus musculus (Mouse) TR15840_c1_g1_i1 O29712 RL11_ARCFU 4.00E-12 GO:0070180; GO:0005840; GO:0003735; GO:0006412 LSU rRNA binding; ribosome; structural constituent of ribosome; translation IPR000911; IPR020786; IPR020783; IPR020785; IPR020784; 50S ribosomal protein L11 rpl11 AF_0538 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) TR15844_c1_g1_i1 P13705 MSH3_MOUSE 2.00E-07 GO:0005524; GO:0008094; GO:0032302; GO:0000403; GO:0019237; GO:0003684; GO:0000406; GO:0000404; GO:0043570; GO:0000710; GO:0000228; GO:0007131; GO:0016447 ATP binding; DNA-dependent ATPase activity; MutSbeta complex; Y-form DNA binding; centromeric DNA binding; damaged DNA binding; double-strand/single-strand DNA junction binding; loop DNA binding; maintenance of DNA repeat elements; meiotic mismatch repair; nuclear chromosome; reciprocal meiotic recombination; somatic recombination of immunoglobulin gene segments IPR007695; IPR000432; IPR007861; IPR007696; IPR016151; IPR007860; IPR027417; DNA mismatch repair protein Msh3 (Protein repair-1) (REP-1) (Protein repair-3) (REP-3) Msh3 Rep-3 Mus musculus (Mouse) TR15849_c0_g1_i1 Q8BKF1 RPOM_MOUSE 8.00E-50 GO:0003677; GO:0003899; GO:0005739; GO:0006351 "DNA binding; DNA-directed RNA polymerase activity; mitochondrion; transcription, DNA-dependent" IPR024075; IPR002092; IPR002885; "DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6)" Polrmt Mus musculus (Mouse) TR15849_c3_g1_i1 Q8BKF1 RPOM_MOUSE 7.00E-49 GO:0003677; GO:0003899; GO:0005739; GO:0006351 "DNA binding; DNA-directed RNA polymerase activity; mitochondrion; transcription, DNA-dependent" IPR024075; IPR002092; IPR002885; "DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6)" Polrmt Mus musculus (Mouse) TR15850_c0_g2_i1 O57579 AMPN_CHICK 5.00E-17 GO:0004177; GO:0016021; GO:0008237; GO:0005886; GO:0006508; GO:0008270 aminopeptidase activity; integral to membrane; metallopeptidase activity; plasma membrane; proteolysis; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (EC 3.4.11.2) (Aminopeptidase Ey) (EC 3.4.11.20) ANPEP APDE Gallus gallus (Chicken) TR15851_c0_g1_i1 Q06806 TIE1_MOUSE 7.00E-07 GO:0005524; GO:0001525; GO:0001701; GO:0016021; GO:0016525; GO:0030336; GO:0018108; GO:0005886; GO:0045026; GO:0032526; GO:0004714 ATP binding; angiogenesis; in utero embryonic development; integral to membrane; negative regulation of angiogenesis; negative regulation of cell migration; peptidyl-tyrosine phosphorylation; plasma membrane; plasma membrane fusion; response to retinoic acid; transmembrane receptor protein tyrosine kinase activity IPR000742; IPR013032; IPR003961; IPR007110; IPR013783; IPR003599; IPR013151; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) Tie1 Tie Tie-1 Mus musculus (Mouse) TR15853_c1_g2_i1 Q6YHK3 CD109_HUMAN 1.00E-13 GO:0031225; GO:0005615; GO:0010951; GO:0005886; GO:0004867 anchored to membrane; extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) TR15866_c4_g1_i1 Q2F637 1433Z_BOMMO 2.00E-44 GO:0005737 cytoplasm IPR000308; IPR023409; IPR023410; 14-3-3 protein zeta 14-3-3zeta Bombyx mori (Silk moth) TR15866_c5_g1_i1 Q26537 14332_SCHMA 6.00E-35 IPR000308; IPR023409; IPR023410; 14-3-3 protein homolog 2 (14-3-3-2) (Fragment) Schistosoma mansoni (Blood fluke) TR1587_c0_g2_i1 Q8JFN7 ACH91_ONCMY 2.00E-15 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-9-I (Nicotinic acetylcholine receptor subunit alpha-9-I) (NACHR alpha-9-I) nachra9 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR15873_c1_g1_i1 Q97AU0 Y719_THEVO 8.00E-10 IPR002589; Uncharacterized protein TV0719 TV0719 TVG0726109 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) TR15877_c3_g1_i1 Q9ES72 CYR61_RAT 8.00E-08 GO:0007155; GO:0006935; GO:0008201; GO:0045766; GO:0030335; GO:0005578; GO:0001558 cell adhesion; chemotaxis; heparin binding; positive regulation of angiogenesis; positive regulation of cell migration; proteinaceous extracellular matrix; regulation of cell growth IPR006208; IPR006207; IPR009030; IPR000867; IPR012395; IPR017891; IPR000884; IPR001007; Protein CYR61 (CCN family member 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) Cyr61 Ccn1 Igfbp10 Rattus norvegicus (Rat) TR15878_c0_g1_i1 Q96KG7 MEG10_HUMAN 5.00E-07 GO:0016323; GO:0042995; GO:0034109; GO:0016021; GO:0055001; GO:0001891; GO:0043654; GO:0051147; GO:0048641; GO:0014719; GO:0014816; GO:0014841 basolateral plasma membrane; cell projection; homotypic cell-cell adhesion; integral to membrane; muscle cell development; phagocytic cup; recognition of apoptotic cell; regulation of muscle cell differentiation; regulation of skeletal muscle tissue development; satellite cell activation; satellite cell differentiation; satellite cell proliferation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) TR15880_c0_g2_i1 Q66H96 CABP7_RAT 1.00E-06 GO:0005794; GO:0005509; GO:0016021; GO:0048471; GO:0005886; GO:0032588 Golgi apparatus; calcium ion binding; integral to membrane; perinuclear region of cytoplasm; plasma membrane; trans-Golgi network membrane IPR011992; IPR018247; IPR002048; IPR001751; Calcium-binding protein 7 (CaBP7) (Calneuron II) (Calneuron-2) Cabp7 Caln2 Rattus norvegicus (Rat) TR15880_c0_g3_i1 Q9FZ75 CML15_ARATH 8.00E-09 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Probable calcium-binding protein CML15 (Calmodulin-like protein 15) CML15 At1g18530 F25I16.13 Arabidopsis thaliana (Mouse-ear cress) TR15882_c0_g1_i1 Q09884 DCR1_SCHPO 2.00E-13 GO:0005524; GO:0016442; GO:0007049; GO:0034613; GO:0031048; GO:0007059; GO:0033562; GO:0005829; GO:0003690; GO:0003725; GO:0035389; GO:1990188; GO:0004386; GO:0031618; GO:0005719; GO:0034399; GO:0005643; GO:0030422; GO:0090052; GO:0051570; GO:0004525; GO:0004540; GO:0008270 ATP binding; RISC complex; cell cycle; cellular protein localization; chromatin silencing by small RNA; chromosome segregation; co-transcriptional gene silencing by RNA interference machinery; cytosol; double-stranded DNA binding; double-stranded RNA binding; establishment of chromatin silencing at silent mating-type cassette; euchromatin binding; helicase activity; nuclear centromeric heterochromatin; nuclear euchromatin; nuclear periphery; nuclear pore; production of siRNA involved in RNA interference; regulation of chromatin silencing at centromere; regulation of histone H3-K9 methylation; ribonuclease III activity; ribonuclease activity; zinc ion binding IPR005034; IPR006935; IPR014001; IPR001650; IPR027417; IPR000999; Protein Dicer (Cell cycle control protein dcr1) (RNA interference pathway protein dcr1) [Includes: Endoribonuclease dcr1 (EC 3.1.26.-); ATP-dependent helicase dcr1 (EC 3.6.4.-)] dcr1 SPCC188.13c SPCC584.10c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR15883_c1_g2_i1 P84987 LECG_CRORU 9.00E-08 GO:0030246; GO:0005576; GO:0046872 carbohydrate binding; extracellular region; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; C-type Lectin CRL (CTL) Crotalus ruber ruber (Red diamond rattlesnake) TR15890_c0_g1_i1 Q6QBQ4 PLS3_RAT 6.00E-14 GO:0006915; GO:0071222; GO:0016021; GO:0031966 apoptotic process; cellular response to lipopolysaccharide; integral to membrane; mitochondrial membrane IPR005552; Phospholipid scramblase 3 (PL scramblase 3) (Ca(2+)-dependent phospholipid scramblase 3) Plscr3 Pls3 Rattus norvegicus (Rat) TR15892_c2_g1_i1 P29995 ITPR2_RAT 3.00E-35 GO:0030424; GO:0005509; GO:0071456; GO:0005789; GO:0070679; GO:0005220; GO:0016021; GO:0043209; GO:0016529 "axon; calcium ion binding; cellular response to hypoxia; endoplasmic reticulum membrane; inositol 1,4,5 trisphosphate binding; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; integral to membrane; myelin sheath; sarcoplasmic reticulum" IPR016024; IPR000699; IPR014821; IPR000493; IPR005821; IPR016093; IPR013662; IPR015925; "Inositol 1,4,5-trisphosphate receptor type 2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor)" Itpr2 Rattus norvegicus (Rat) TR15897_c1_g1_i2 Q9US35 DSD1_SCHPO 1.00E-12 GO:0008721; GO:0008784; GO:0005829; GO:0071852; GO:0005634 D-serine ammonia-lyase activity; alanine racemase activity; cytosol; fungal-type cell wall organization or biogenesis; nucleus IPR001608; IPR026956; D-serine dehydratase (EC 4.3.1.18) (D-serine deaminase) (DSD) SPAC1039.06 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR15902_c0_g1_i1 Q297K8 JAGN_DROPS 2.00E-18 GO:0022416; GO:0005789; GO:0007029; GO:0006887; GO:0016021; GO:0001555 chaeta development; endoplasmic reticulum membrane; endoplasmic reticulum organization; exocytosis; integral to membrane; oocyte growth IPR009787; Protein jagunal jagn GA10683 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR15907_c0_g1_i1 A6NK53 ZN233_HUMAN 7.00E-06 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 233 ZNF233 Homo sapiens (Human) TR15910_c0_g1_i1 Q7Z0T3 TEMPT_APLCA 7.00E-26 GO:0005576 extracellular region Temptin Aplysia californica (California sea hare) TR15913_c2_g1_i1 Q5RK09 EIF3G_RAT 5.00E-23 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0000166; GO:0005634; GO:0048471; GO:0006446; GO:0003743; GO:0006413 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; nucleotide binding; nucleus; perinuclear region of cytoplasm; regulation of translational initiation; translation initiation factor activity; translational initiation IPR017334; IPR024675; IPR012677; IPR000504; Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) Eif3g Eif3s4 Rattus norvegicus (Rat) TR15924_c2_g1_i1 P04843 RPN1_HUMAN 2.00E-26 GO:0006614; GO:0004579; GO:0016021; GO:0042470; GO:0008250; GO:0043687; GO:0018279; GO:0005791; GO:0006412 SRP-dependent cotranslational protein targeting to membrane; dolichyl-diphosphooligosaccharide-protein glycotransferase activity; integral to membrane; melanosome; oligosaccharyltransferase complex; post-translational protein modification; protein N-linked glycosylation via asparagine; rough endoplasmic reticulum; translation IPR007676; Protein modification; protein glycosylation. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (EC 2.4.99.18) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) RPN1 Homo sapiens (Human) TR15926_c1_g1_i1 P54185 OBA5_DROME 1.00E-06 GO:0005576 extracellular region IPR001858; IPR008914; Putative odorant-binding protein A5 (Antennal protein 5) a5 CG5430 Drosophila melanogaster (Fruit fly) TR15926_c1_g1_i2 Q09288 YQK4_CAEEL 1.00E-06 IPR008914; Uncharacterized protein C56G2.4 C56G2.4 Caenorhabditis elegans TR15926_c3_g1_i1 Q9XFK7 MFT_ARATH 1.00E-07 GO:0005737; GO:0005634; GO:0010030; GO:0009737 cytoplasm; nucleus; positive regulation of seed germination; response to abscisic acid stimulus IPR001858; IPR008914; Protein MOTHER of FT and TF 1 MFT At1g18100 E12A11 T10F20.11 T10F20.7 Arabidopsis thaliana (Mouse-ear cress) TR15929_c2_g1_i1 Q866A2 ACHA7_MACMU 7.00E-24 GO:0042113; GO:0042110; GO:0042166; GO:0015464; GO:0004889; GO:0005892; GO:0000187; GO:0016324; GO:0008306; GO:0048149; GO:0035095; GO:0001540; GO:0006816; GO:0030054; GO:0006874; GO:0017081; GO:0050890; GO:0006897; GO:0009897; GO:0060112; GO:0007613; GO:0050728; GO:0032691; GO:0032715; GO:0032720; GO:0045766; GO:0008284; GO:0001988; GO:0045211; GO:0042803; GO:0042391; GO:0014061; GO:0032225; GO:0032094; GO:0001666; GO:0035094; GO:0030317; GO:0007271; GO:0015643 "B cell activation; T cell activation; acetylcholine binding; acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; activation of MAPK activity; apical plasma membrane; associative learning; behavioral response to ethanol; behavioral response to nicotine; beta-amyloid binding; calcium ion transport; cell junction; cellular calcium ion homeostasis; chloride channel regulator activity; cognition; endocytosis; external side of plasma membrane; generation of ovulation cycle rhythm; memory; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production; positive regulation of angiogenesis; positive regulation of cell proliferation; positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure; postsynaptic membrane; protein homodimerization activity; regulation of membrane potential; regulation of norepinephrine secretion; regulation of synaptic transmission, dopaminergic; response to food; response to hypoxia; response to nicotine; sperm motility; synaptic transmission, cholinergic; toxic substance binding" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 Macaca mulatta (Rhesus macaque) TR15929_c3_g1_i1 Q494W8 CRFM7_HUMAN 7.00E-15 GO:0005230; GO:0016021 extracellular ligand-gated ion channel activity; integral to membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; CHRNA7-FAM7A fusion protein (CHRNA7-DR1) (D-10) CHRFAM7A Homo sapiens (Human) TR15931_c0_g2_i1 Q9NWC5 TM45A_HUMAN 6.00E-08 GO:0016021 integral to membrane IPR006904; Transmembrane protein 45A (DNA polymerase-transactivated protein 4) (Dermal papilla-derived protein 7) TMEM45A DERP7 DNAPTP4 Homo sapiens (Human) TR15931_c1_g1_i1 Q6NS09 TM45B_XENLA 4.00E-15 GO:0016021 integral to membrane IPR006904; Transmembrane protein 45B tmem45b Xenopus laevis (African clawed frog) TR15938_c0_g2_i1 Q13489 BIRC3_HUMAN 3.00E-10 GO:0038061; GO:0035666; GO:0006915; GO:0007166; GO:0005829; GO:0045087; GO:0070266; GO:0043066; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0043123; GO:0039535; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0034138; GO:0034142; GO:0004842; GO:0008270 Q13546; O43353; Q9Y572; P57078; Q12933 NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; apoptotic process; cell surface receptor signaling pathway; cytosol; innate immune response; necroptosis; negative regulation of apoptotic process; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of RIG-I signaling pathway; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Apoptosis inhibitor 2) (API2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (IAP-1) (hIAP-1) (hIAP1) (RING finger protein 49) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 IAP1 MIHC RNF49 Homo sapiens (Human) TR1594_c0_g1_i1 P48733 UROM_BOVIN 7.00E-18 GO:0031225; GO:0016324; GO:0016323; GO:0005509; GO:0060170; GO:0005576; GO:0072372; GO:0000922 anchored to membrane; apical plasma membrane; basolateral plasma membrane; calcium ion binding; cilium membrane; extracellular region; primary cilium; spindle pole IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR023413; IPR009030; IPR001507; IPR017977; "Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]" UMOD Bos taurus (Bovine) TR15940_c3_g1_i1 Q6YHK3 CD109_HUMAN 3.00E-08 GO:0031225; GO:0005615; GO:0010951; GO:0005886; GO:0004867 anchored to membrane; extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) TR15947_c0_g1_i1 O60500 NPHN_HUMAN 1.00E-06 GO:0007254; GO:0007155; GO:0042995; GO:0007588; GO:0032836; GO:0072015; GO:0005887; GO:0007520; GO:0030838; GO:0044062; GO:0007519; GO:0036057 P46940; P16333 JNK cascade; cell adhesion; cell projection; excretion; glomerular basement membrane development; glomerular visceral epithelial cell development; integral to plasma membrane; myoblast fusion; positive regulation of actin filament polymerization; regulation of excretion; skeletal muscle tissue development; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) NPHS1 NPHN Homo sapiens (Human) TR1595_c0_g1_i1 Q5H8A4 PIGG_HUMAN 4.00E-11 GO:0006501; GO:0051267; GO:0005789; GO:0016021; GO:0016254 C-terminal protein lipidation; CP2 mannose-ethanolamine phosphotransferase activity; endoplasmic reticulum membrane; integral to membrane; preassembly of GPI anchor in ER membrane IPR017849; IPR017850; IPR002591; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (GPI7 homolog) (hGPI7) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G) PIGG GPI7 UNQ1930/PRO4405 Homo sapiens (Human) TR15950_c2_g1_i1 O60673 DPOLZ_HUMAN 2.00E-10 GO:0051539; GO:0003677; GO:0006261; GO:0003887; GO:0005694; GO:0046872; GO:0000166; GO:0005634; GO:0019985; GO:0016035 Q9UI95 "4 iron, 4 sulfur cluster binding; DNA binding; DNA-dependent DNA replication; DNA-directed DNA polymerase activity; chromosome; metal ion binding; nucleotide binding; nucleus; translesion synthesis; zeta DNA polymerase complex" IPR006172; IPR017964; IPR006133; IPR006134; IPR023211; IPR012337; IPR025687; DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) REV3L POLZ REV3 Homo sapiens (Human) TR15951_c0_g1_i1 P51954 NEK1_MOUSE 5.00E-43 GO:0005524; GO:0051301; GO:0030030; GO:0005813; GO:0005737; GO:0046872; GO:0007067; GO:0005634; GO:0018108; GO:0004672; GO:0004674; GO:0004713; GO:0006974; GO:0010212 ATP binding; cell division; cell projection organization; centrosome; cytoplasm; metal ion binding; mitosis; nucleus; peptidyl-tyrosine phosphorylation; protein kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; response to DNA damage stimulus; response to ionizing radiation IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) Nek1 Mus musculus (Mouse) TR15955_c0_g1_i1 Q8JHV9 BIR7A_XENLA 1.00E-34 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR15955_c0_g2_i1 A9JTP3 BIRC7_XENTR 1.00E-23 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP) (Embryonic/Egg IAP) (EIAP/XLX) birc7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR15959_c0_g1_i1 Q9LQU4 PCR2_ARATH 7.00E-13 GO:0016021; GO:0005886; GO:0006979 integral to membrane; plasma membrane; response to oxidative stress IPR006461; Protein PLANT CADMIUM RESISTANCE 2 (AtPCR2) PCR2 At1g14870 F10B6.27 Arabidopsis thaliana (Mouse-ear cress) TR15971_c1_g1_i1 P35448 TSP1_XENLA 3.00E-07 GO:0005509; GO:0007155; GO:0005576; GO:0008201; GO:0016529 calcium ion binding; cell adhesion; extracellular region; heparin binding; sarcoplasmic reticulum IPR026823; IPR008985; IPR013320; IPR000742; IPR013032; IPR024731; IPR001791; IPR000884; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-1 thbs1 tsp1 Xenopus laevis (African clawed frog) TR15972_c0_g1_i1 Q5RCT0 CX6B1_PONAB 5.00E-29 GO:0004129; GO:0005758 cytochrome-c oxidase activity; mitochondrial intermembrane space IPR003213; Cytochrome c oxidase subunit 6B1 (Cytochrome c oxidase subunit VIb isoform 1) (COX VIb-1) COX6B1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR15973_c0_g1_i1 Q2T9W3 CCD63_BOVIN 2.00E-37 Coiled-coil domain-containing protein 63 CCDC63 Bos taurus (Bovine) TR15974_c0_g1_i1 P62083 RS7_RAT 2.00E-113 GO:0030686; GO:0022627; GO:0005815; GO:0006364; GO:0042274; GO:0032040; GO:0003735; GO:0006412 90S preribosome; cytosolic small ribosomal subunit; microtubule organizing center; rRNA processing; ribosomal small subunit biogenesis; small-subunit processome; structural constituent of ribosome; translation IPR000554; 40S ribosomal protein S7 (S8) Rps7 Rattus norvegicus (Rat) TR15976_c0_g1_i1 Q0V9W6 BTBD6_XENTR 9.00E-06 GO:0000932 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6 btbd6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR15976_c3_g1_i1 P58545 BTBD3_MOUSE 2.00E-07 IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 3 Btbd3 Mus musculus (Mouse) TR15980_c2_g1_i1 Q8R189 PAQRA_MOUSE 2.00E-15 GO:0000139; GO:0019835; GO:0016021; GO:0048471 Golgi membrane; cytolysis; integral to membrane; perinuclear region of cytoplasm IPR004254; IPR005744; Monocyte to macrophage differentiation factor 2 (Progestin and adipoQ receptor family member X) Mmd2 Paqr10 Mus musculus (Mouse) TR15984_c0_g1_i1 Q5RD73 DUS3_PONAB 3.00E-17 GO:0033549; GO:0005829; GO:0001772; GO:0070373; GO:0046329; GO:0050868; GO:0050860; GO:0005634; GO:0045931; GO:0004725; GO:0008138 MAP kinase phosphatase activity; cytosol; immunological synapse; negative regulation of ERK1 and ERK2 cascade; negative regulation of JNK cascade; negative regulation of T cell activation; negative regulation of T cell receptor signaling pathway; nucleus; positive regulation of mitotic cell cycle; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR020417; IPR020405; IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Vaccinia H1-related phosphatase) (VHR) DUSP3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR15988_c2_g1_i1 Q9BZE3 BARH1_HUMAN 2.00E-10 GO:0001077; GO:0030901; GO:0043524; GO:0001764; GO:0005634; GO:0007605; GO:0043565 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; midbrain development; negative regulation of neuron apoptotic process; neuron migration; nucleus; sensory perception of sound; sequence-specific DNA binding IPR017970; IPR001356; IPR020479; IPR009057; BarH-like 1 homeobox protein BARHL1 FKSG31 Homo sapiens (Human) TR15993_c2_g1_i1 Q0IIY2 WSCD1_XENTR 1.00E-09 GO:0016021; GO:0008146 integral to membrane; sulfotransferase activity IPR027417; IPR000863; IPR002889; IPR013994; WSC domain-containing protein 1 wscd1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR15995_c0_g1_i1 Q5PPV2 TEKT4_XENLA 7.00E-23 GO:0035085; GO:0005874; GO:0000226 cilium axoneme; microtubule; microtubule cytoskeleton organization IPR000435; Tektin-4 tekt4 Xenopus laevis (African clawed frog) TR15996_c2_g1_i1 Q9CUS9 SPPL3_MOUSE 3.00E-67 GO:0030660; GO:0042500; GO:0071458; GO:0071556; GO:0042803; GO:0006508; GO:0005791 "Golgi-associated vesicle membrane; aspartic endopeptidase activity, intramembrane cleaving; integral to cytosolic side of endoplasmic reticulum membrane; integral to lumenal side of endoplasmic reticulum membrane; protein homodimerization activity; proteolysis; rough endoplasmic reticulum" IPR007369; IPR006639; Signal peptide peptidase-like 3 (SPP-like 3) (EC 3.4.23.-) (Intramembrane protease 2) (IMP-2) (Presenilin-like protein 4) Sppl3 Imp2 Psl4 Usmg3 Mus musculus (Mouse) TR15997_c1_g1_i1 P35031 TRY1_SALSA 1.00E-15 GO:0007586; GO:0005615; GO:0046872; GO:0006508; GO:0004252 digestion; extracellular space; metal ion binding; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Trypsin-1 (EC 3.4.21.4) (Trypsin I) Salmo salar (Atlantic salmon) TR16008_c0_g1_i1 Q8ISP0 RS18_BRABE 2.00E-80 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR027437; IPR001892; IPR010979; IPR018269; 40S ribosomal protein S18 RPS18 Branchiostoma belcheri (Amphioxus) TR16010_c0_g1_i1 O75095 MEGF6_HUMAN 1.00E-09 GO:0005509; GO:0005576 O15265; O00555 calcium ion binding; extracellular region IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR002049; IPR011489; IPR009030; Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) TR16020_c0_g1_i1 A2CI35 DUSTY_STRPU 3.00E-20 GO:0005524; GO:0005737; GO:0018108; GO:0004674; GO:0004712; GO:0004713 ATP binding; cytoplasm; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (Receptor-interacting serine/threonine-protein kinase 5) DSTYK RIPK5 Strongylocentrotus purpuratus (Purple sea urchin) TR16023_c1_g2_i1 Q5J6M8 RTN3A_XENLA 2.00E-30 GO:0000139; GO:0005789; GO:0016021; GO:0016192 Golgi membrane; endoplasmic reticulum membrane; integral to membrane; vesicle-mediated transport IPR003388; Reticulon-3-A (RTN3.1) rtn3-a Xenopus laevis (African clawed frog) TR16023_c1_g3_i1 Q9NQC3 RTN4_HUMAN 1.00E-34 GO:0001525; GO:0006915; GO:0007413; GO:0060317; GO:0042995; GO:0021801; GO:0071786; GO:0030176; GO:0030517; GO:0043025; GO:0048011; GO:0005635; GO:0005886; GO:0042981; GO:2000172; GO:0030334 Q8WXF7; O43639 angiogenesis; apoptotic process; axonal fasciculation; cardiac epithelial to mesenchymal transition; cell projection; cerebral cortex radial glia guided migration; endoplasmic reticulum tubular network organization; integral to endoplasmic reticulum membrane; negative regulation of axon extension; neuronal cell body; neurotrophin TRK receptor signaling pathway; nuclear envelope; plasma membrane; regulation of apoptotic process; regulation of branching morphogenesis of a nerve; regulation of cell migration IPR003388; Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) RTN4 KIAA0886 NOGO My043 SP1507 Homo sapiens (Human) TR16023_c1_g4_i1 Q99P72 RTN4_MOUSE 5.00E-33 GO:0001525; GO:0007413; GO:0060317; GO:0042995; GO:0021801; GO:0071786; GO:0030176; GO:0030517; GO:0043025; GO:0005635; GO:2000172; GO:0030334 angiogenesis; axonal fasciculation; cardiac epithelial to mesenchymal transition; cell projection; cerebral cortex radial glia guided migration; endoplasmic reticulum tubular network organization; integral to endoplasmic reticulum membrane; negative regulation of axon extension; neuronal cell body; nuclear envelope; regulation of branching morphogenesis of a nerve; regulation of cell migration IPR003388; Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) Rtn4 Kiaa0886 Nogo Mus musculus (Mouse) TR16023_c2_g1_i1 A7MC64 RTN1_XENTR 2.00E-23 GO:0005789; GO:0016021; GO:0005634 endoplasmic reticulum membrane; integral to membrane; nucleus IPR003388; Reticulon-1 rtn1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR16027_c0_g1_i1 Q09437 YP62_CAEEL 1.00E-32 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR002290; IPR008271; Putative serine/threonine-protein kinase B0495.2 (EC 2.7.11.1) B0495.2 Caenorhabditis elegans TR16027_c0_g2_i1 Q5E9Y0 CDK2_BOVIN 3.00E-93 GO:0005524; GO:0015030; GO:0006281; GO:0007265; GO:0000805; GO:0000806; GO:0051301; GO:0000781; GO:0000793; GO:0000307; GO:0004693; GO:0005768; GO:0035173; GO:0007126; GO:0046872; GO:0005815; GO:0007067; GO:0005634; GO:0032298; GO:0008284; GO:0045893; GO:0006813; GO:0060968; GO:0005667 "ATP binding; Cajal body; DNA repair; Ras protein signal transduction; X chromosome; Y chromosome; cell division; chromosome, telomeric region; condensed chromosome; cyclin-dependent protein kinase holoenzyme complex; cyclin-dependent protein serine/threonine kinase activity; endosome; histone kinase activity; meiosis; metal ion binding; microtubule organizing center; mitosis; nucleus; positive regulation of DNA-dependent DNA replication initiation; positive regulation of cell proliferation; positive regulation of transcription, DNA-dependent; potassium ion transport; regulation of gene silencing; transcription factor complex" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) CDK2 CDKN2 Bos taurus (Bovine) TR16028_c0_g1_i1 Q9NUV9 GIMA4_HUMAN 7.00E-07 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR16037_c1_g1_i1 A0JMD4 TPC2_DANRE 1.00E-30 GO:0072345; GO:0016021; GO:0005765; GO:0006939; GO:0005245 NAADP-sensitive calcium-release channel activity; integral to membrane; lysosomal membrane; smooth muscle contraction; voltage-gated calcium channel activity IPR027359; IPR005821; Two pore calcium channel protein 2 (Voltage-dependent calcium channel protein TPC2) tpcn2 tpc2 zgc:152898 Danio rerio (Zebrafish) (Brachydanio rerio) TR16039_c0_g1_i1 Q26636 CATL_SARPE 5.00E-129 GO:0030154; GO:0008234; GO:0005764; GO:0007275; GO:0006508 cell differentiation; cysteine-type peptidase activity; lysosome; multicellular organismal development; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) TR16047_c0_g1_i1 Q9GLV6 DDX58_PIG 8.00E-10 GO:0005524; GO:0008026; GO:0039529; GO:0015629; GO:0005737; GO:0003725; GO:0045087; GO:0002230; GO:0032727; GO:0032728; GO:0030334; GO:0032587; GO:0003727; GO:0005923; GO:0008270 ATP binding; ATP-dependent helicase activity; RIG-I signaling pathway; actin cytoskeleton; cytoplasm; double-stranded RNA binding; innate immune response; positive regulation of defense response to virus by host; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; regulation of cell migration; ruffle membrane; single-stranded RNA binding; tight junction; zinc ion binding IPR011545; IPR014001; IPR001650; IPR027417; IPR021673; Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RHIV-1) (RIG-I-like receptor 1) (RLR-1) (RNA helicase induced by virus) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) DDX58 Sus scrofa (Pig) TR16061_c1_g1_i1 Q8IXQ5 KLHL7_HUMAN 7.00E-22 GO:0031463; GO:0005737; GO:0005730; GO:0005886; GO:0042803; GO:0016567 Cul3-RING ubiquitin ligase complex; cytoplasm; nucleolus; plasma membrane; protein homodimerization activity; protein ubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 7 KLHL7 Homo sapiens (Human) TR16079_c1_g1_i1 Q9UPN3 MACF1_HUMAN 2.00E-32 GO:0016887; GO:0005794; GO:0043001; GO:0016055; GO:0015629; GO:0051015; GO:0005509; GO:0007050; GO:0006928; GO:0007163; GO:0001707; GO:0005874; GO:0008017; GO:0030177; GO:0006620; GO:0010632; GO:0051893; GO:0032886; GO:0032587; GO:0042060 Q9NRI5 ATPase activity; Golgi apparatus; Golgi to plasma membrane protein transport; Wnt receptor signaling pathway; actin cytoskeleton; actin filament binding; calcium ion binding; cell cycle arrest; cellular component movement; establishment or maintenance of cell polarity; mesoderm formation; microtubule; microtubule binding; positive regulation of Wnt receptor signaling pathway; posttranslational protein targeting to membrane; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of microtubule-based process; ruffle membrane; wound healing IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; IPR003108; IPR001101; IPR018159; IPR002017; "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)" MACF1 ABP620 ACF7 KIAA0465 KIAA1251 Homo sapiens (Human) TR16088_c1_g1_i1 P45878 FKBP2_MOUSE 2.00E-47 GO:0005528; GO:0005789; GO:0016020; GO:0003755; GO:0006457 FK506 binding; endoplasmic reticulum membrane; membrane; peptidyl-prolyl cis-trans isomerase activity; protein folding IPR023566; IPR001179; Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (13 kDa FK506-binding protein) (13 kDa FKBP) (FKBP-13) (FK506-binding protein 2) (FKBP-2) (Immunophilin FKBP13) (Rotamase) Fkbp2 Fkbp13 Mus musculus (Mouse) TR16093_c0_g1_i1 Q22366 RIM_CAEEL 5.00E-53 GO:0030742; GO:0017137; GO:0030424; GO:0005509; GO:0030054; GO:0030421; GO:0006886; GO:0040011; GO:0007626; GO:0007617; GO:0040018; GO:0032224; GO:0048786; GO:0008104; GO:0043051; GO:0007271; GO:0016082 "GTP-dependent protein binding; Rab GTPase binding; axon; calcium ion binding; cell junction; defecation; intracellular protein transport; locomotion; locomotory behavior; mating behavior; positive regulation of multicellular organism growth; positive regulation of synaptic transmission, cholinergic; presynaptic active zone; protein localization; regulation of pharyngeal pumping; synaptic transmission, cholinergic; synaptic vesicle priming" IPR000008; IPR001478; IPR017455; IPR010911; IPR011011; IPR013083; Rab-3-interacting molecule unc-10 (Rim) (Uncoordinated protein 10) unc-10 T10A3.1 Caenorhabditis elegans TR16093_c0_g2_i1 Q9UQ26 RIMS2_HUMAN 8.00E-69 GO:0019933; GO:0017156; GO:0048791; GO:0030054; GO:0030073; GO:0006886; GO:0046872; GO:0042734; GO:0017157; GO:0042391 P16333 cAMP-mediated signaling; calcium ion-dependent exocytosis; calcium ion-dependent exocytosis of neurotransmitter; cell junction; insulin secretion; intracellular protein transport; metal ion binding; presynaptic membrane; regulation of exocytosis; regulation of membrane potential IPR000008; IPR001478; IPR017455; IPR010911; IPR011011; IPR013083; Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) RIMS2 KIAA0751 RAB3IP3 RIM2 Homo sapiens (Human) TR16093_c3_g1_i1 Q9Y6V0 PCLO_HUMAN 1.00E-10 GO:0019933; GO:0005509; GO:0005544; GO:0030054; GO:0005856; GO:0007010; GO:0030073; GO:0016020; GO:0005522; GO:0017157; GO:0045202; GO:0008021; GO:0016079; GO:0005215 cAMP-mediated signaling; calcium ion binding; calcium-dependent phospholipid binding; cell junction; cytoskeleton; cytoskeleton organization; insulin secretion; membrane; profilin binding; regulation of exocytosis; synapse; synaptic vesicle; synaptic vesicle exocytosis; transporter activity IPR000008; IPR001565; IPR011011; IPR008899; IPR013083; Protein piccolo (Aczonin) PCLO ACZ KIAA0559 Homo sapiens (Human) TR16096_c0_g1_i1 Q54FC5 Y0965_DICDI 7.00E-06 GO:0005737; GO:0008270 cytoplasm; zinc ion binding IPR008974; IPR001841; IPR013083; IPR001293; TNF receptor-associated factor family protein DDB_G0290965 DDB_G0290965 Dictyostelium discoideum (Slime mold) TR16096_c1_g1_i1 Q60803 TRAF3_MOUSE 3.00E-87 GO:0035631; GO:0008063; GO:0006915; GO:0005768; GO:0045087; GO:0009898; GO:0032088; GO:0042981; GO:0050688; GO:0032648; GO:0030162; GO:0002224; GO:0033209; GO:0004842; GO:0008270 Q8VCF0; O35305; P47741; P39429 CD40 receptor complex; Toll signaling pathway; apoptotic process; endosome; innate immune response; internal side of plasma membrane; negative regulation of NF-kappaB transcription factor activity; regulation of apoptotic process; regulation of defense response to virus; regulation of interferon-beta production; regulation of proteolysis; toll-like receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR013323; IPR012227; IPR008974; IPR027128; IPR001841; IPR013083; IPR017907; IPR001293; TNF receptor-associated factor 3 (EC 6.3.2.-) (CD40 receptor-associated factor 1) (CRAF1) (TRAFAMN) Traf3 Craf1 Trafamn Mus musculus (Mouse) TR16097_c0_g1_i1 P79266 GASR_BOVIN 3.00E-06 GO:0048565; GO:0007204; GO:0001696; GO:0015054; GO:0048732; GO:0016021; GO:0005886; GO:0008284 digestive tract development; elevation of cytosolic calcium ion concentration; gastric acid secretion; gastrin receptor activity; gland development; integral to membrane; plasma membrane; positive regulation of cell proliferation IPR009126; IPR000314; IPR000276; IPR017452; Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R) CCKBR Bos taurus (Bovine) TR16098_c0_g1_i1 Q66KX4 MED29_XENLA 4.00E-32 GO:0016592; GO:0006355; GO:0006351 "mediator complex; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR021018; Mediator of RNA polymerase II transcription subunit 29 (Intersex-like protein) (Mediator complex subunit 29) med29 ixl Xenopus laevis (African clawed frog) TR1610_c0_g1_i1 Q80ZD8 AMGO1_MOUSE 5.00E-06 GO:0007413; GO:0007409; GO:0007157; GO:0007156; GO:0016021; GO:0042552; GO:0005886; GO:0050772 Q03717 axonal fasciculation; axonogenesis; heterophilic cell-cell adhesion; homophilic cell adhesion; integral to membrane; myelination; plasma membrane; positive regulation of axonogenesis IPR000483; IPR007110; IPR013783; IPR013098; IPR003599; IPR001611; IPR003591; IPR000372; Amphoterin-induced protein 1 (AMIGO-1) (Alivin-2) Amigo1 Ali2 Amigo Kiaa1163 Mus musculus (Mouse) TR16101_c0_g1_i1 P57756 FCN2_RAT 2.00E-34 GO:0005581; GO:0001867 "collagen; complement activation, lectin pathway" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) Fcn2 Fcnb Rattus norvegicus (Rat) TR16107_c3_g2_i1 Q9N0W2 FUT8_BOVIN 2.00E-76 GO:0032580; GO:0036071; GO:0008424; GO:0016021; GO:0033578 Golgi cisterna membrane; N-glycan fucosylation; glycoprotein 6-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation in Golgi IPR015827; IPR027350; IPR001452; Protein modification; protein glycosylation. "Alpha-(1,6)-fucosyltransferase (Alpha1-6FucT) (EC 2.4.1.68) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase)" FUT8 Bos taurus (Bovine) TR1611_c0_g1_i3 P54802 ANAG_HUMAN 5.00E-20 GO:0004561; GO:0005975; GO:0021680; GO:0006027; GO:0060119; GO:0045475; GO:0043202; GO:0007040; GO:0042474; GO:0007399; GO:0046548; GO:0044281 alpha-N-acetylglucosaminidase activity; carbohydrate metabolic process; cerebellar Purkinje cell layer development; glycosaminoglycan catabolic process; inner ear receptor cell development; locomotor rhythm; lysosomal lumen; lysosome organization; middle ear morphogenesis; nervous system development; retinal rod cell development; small molecule metabolic process IPR017853; IPR007781; IPR024732; IPR024240; IPR024733; Alpha-N-acetylglucosaminidase (EC 3.2.1.50) (N-acetyl-alpha-glucosaminidase) (NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form] NAGLU UFHSD1 Homo sapiens (Human) TR16115_c0_g1_i1 Q9QZH0 FZD4_RAT 4.00E-27 GO:0004930; GO:0030165; GO:0007223; GO:0042813; GO:0007420; GO:0060070; GO:0042995; GO:0009986; GO:0005911; GO:0061301; GO:0005737; GO:0009790; GO:0035426; GO:0016021; GO:0031987; GO:0010812; GO:0005886; GO:0043507; GO:0051091; GO:0045893; GO:0042701; GO:0030947; GO:0061304; GO:0007605; GO:0034446; GO:0001570 "G-protein coupled receptor activity; PDZ domain binding; Wnt receptor signaling pathway, calcium modulating pathway; Wnt-activated receptor activity; brain development; canonical Wnt receptor signaling pathway; cell projection; cell surface; cell-cell junction; cerebellum vasculature morphogenesis; cytoplasm; embryo development; extracellular matrix-cell signaling; integral to membrane; locomotion involved in locomotory behavior; negative regulation of cell-substrate adhesion; plasma membrane; positive regulation of JUN kinase activity; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; progesterone secretion; regulation of vascular endothelial growth factor receptor signaling pathway; retinal blood vessel morphogenesis; sensory perception of sound; substrate adhesion-dependent cell spreading; vasculogenesis" IPR000539; IPR015526; IPR020067; IPR026551; IPR017981; Frizzled-4 (Fz-4) (rFz4) (CD antigen CD344) Fzd4 Rattus norvegicus (Rat) TR16120_c3_g1_i1 Q8NEP7 KLDC9_HUMAN 3.00E-09 IPR011043; IPR015915; Kelch domain-containing protein 9 (Kelch/ankyrin repeat-containing cyclin A1-interacting protein) KLHDC9 KARCA1 Homo sapiens (Human) TR16122_c0_g1_i1 P24032 MLRN_CHICK 3.00E-79 GO:0005509; GO:0016459 calcium ion binding; myosin complex IPR011992; IPR018247; IPR002048; "Myosin regulatory light chain 2, smooth muscle minor isoform (MLC-2) (DTNB) (G1) (Isoform L20-B1)" Gallus gallus (Chicken) TR16126_c0_g1_i1 Q3ZMH1 SC5A8_DANRE 3.00E-31 GO:0016021; GO:0015355; GO:0006814; GO:0015293 integral to membrane; secondary active monocarboxylate transmembrane transporter activity; sodium ion transport; symporter activity IPR001734; IPR019900; Sodium-coupled monocarboxylate transporter 1 (Electrogenic sodium monocarboxylate cotransporter) (zSMCTe) (Sodium solute symporter family 5 member 8 protein) (Solute carrier family 5 member 8) slc5a8 slc5a8l smcte zgc:152716 Danio rerio (Zebrafish) (Brachydanio rerio) TR16135_c2_g1_i1 P49193 RALB_TODPA 1.00E-35 GO:0016021; GO:0050896; GO:0006810; GO:0007601 integral to membrane; response to stimulus; transport; visual perception IPR001251; IPR009038; Retinal-binding protein (RALBP) Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus) TR16135_c3_g1_i1 P49193 RALB_TODPA 2.00E-32 GO:0016021; GO:0050896; GO:0006810; GO:0007601 integral to membrane; response to stimulus; transport; visual perception IPR001251; IPR009038; Retinal-binding protein (RALBP) Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus) TR16135_c8_g1_i1 O76054 S14L2_HUMAN 3.00E-19 GO:0005737; GO:0016021; GO:0005634; GO:0005543; GO:0045893; GO:0045540; GO:0006351; GO:0005215; GO:0008431 "cytoplasm; integral to membrane; nucleus; phospholipid binding; positive regulation of transcription, DNA-dependent; regulation of cholesterol biosynthetic process; transcription, DNA-dependent; transporter activity; vitamin E binding" IPR001071; IPR001251; IPR011074; IPR009038; SEC14-like protein 2 (Alpha-tocopherol-associated protein) (TAP) (hTAP) (Squalene transfer protein) (Supernatant protein factor) (SPF) SEC14L2 C22orf6 KIAA1186 KIAA1658 Homo sapiens (Human) TR16138_c2_g1_i1 P53349 M3K1_MOUSE 7.00E-27 GO:0005524; GO:0008545; GO:0004709; GO:0000186; GO:0008637; GO:0005829; GO:0003382; GO:0061029; GO:0030838; GO:0030334; GO:0007179; GO:0042060; GO:0008270 ATP binding; JUN kinase kinase activity; MAP kinase kinase kinase activity; activation of MAPKK activity; apoptotic mitochondrial changes; cytosol; epithelial cell morphogenesis; eyelid development in camera-type eye; positive regulation of actin filament polymerization; regulation of cell migration; transforming growth factor beta receptor signaling pathway; wound healing; zinc ion binding IPR016024; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR001841; IPR013083; IPR007527; Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) Map3k1 Mekk Mekk1 Mus musculus (Mouse) TR16139_c0_g1_i1 O75165 DJC13_HUMAN 2.00E-34 GO:0005765 lysosomal membrane IPR011989; IPR016024; IPR001623; IPR025640; IPR003169; DnaJ homolog subfamily C member 13 (Required for receptor-mediated endocytosis 8) (RME-8) DNAJC13 KIAA0678 RME8 Homo sapiens (Human) TR16141_c1_g1_i1 A8E4S7 MB213_DANRE 2.00E-11 IPR024810; Protein mab-21-like 3 mab21L3 si:ch211-246m4.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR16141_c1_g1_i2 Q8N8X9 MB213_HUMAN 5.00E-13 IPR024810; IPR024802; Protein mab-21-like 3 MAB21L3 C1orf161 Homo sapiens (Human) TR16146_c0_g2_i1 Q17031 CDC42_ANOGA 5.00E-11 GO:0005525; GO:0005912; GO:0005622; GO:0007275; GO:0005886; GO:0007264 GTP binding; adherens junction; intracellular; multicellular organismal development; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Cdc42 homolog (25 kDa GTP-binding protein) Cdc42 AGAP002440 Anopheles gambiae (African malaria mosquito) TR16153_c0_g1_i2 Q5UPA0 YL025_MIMIV 8.00E-08 IPR002110; IPR020683; Putative ankyrin repeat protein L25 MIMI_L25 Acanthamoeba polyphaga mimivirus (APMV) TR16155_c0_g1_i1 Q02858 TIE2_MOUSE 3.00E-06 GO:0005524; GO:0048014; GO:0016337; GO:0007160; GO:0005737; GO:0005856; GO:0001935; GO:0005576; GO:0005925; GO:0060347; GO:0030097; GO:0016021; GO:0005887; GO:0016525; GO:2000352; GO:0001569; GO:0005886; GO:0070374; GO:0045766; GO:0010595; GO:0051894; GO:0033138; GO:0043552; GO:0014068; GO:0051897; GO:0030949; GO:0046777; GO:0004713; GO:0004872; GO:0001936; GO:0032878; GO:0032526; GO:0002040; GO:0034446; GO:0004714; GO:0001570 Q60631; Q03160 ATP binding; Tie signaling pathway; cell-cell adhesion; cell-matrix adhesion; cytoplasm; cytoskeleton; endothelial cell proliferation; extracellular region; focal adhesion; heart trabecula formation; hemopoiesis; integral to membrane; integral to plasma membrane; negative regulation of angiogenesis; negative regulation of endothelial cell apoptotic process; patterning of blood vessels; plasma membrane; positive regulation of ERK1 and ERK2 cascade; positive regulation of angiogenesis; positive regulation of endothelial cell migration; positive regulation of focal adhesion assembly; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of vascular endothelial growth factor receptor signaling pathway; protein autophosphorylation; protein tyrosine kinase activity; receptor activity; regulation of endothelial cell proliferation; regulation of establishment or maintenance of cell polarity; response to retinoic acid; sprouting angiogenesis; substrate adhesion-dependent cell spreading; transmembrane receptor protein tyrosine kinase activity; vasculogenesis IPR000742; IPR013032; IPR002049; IPR003961; IPR007110; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR018941; IPR008266; IPR020635; Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b) Tek Hyk Tie-2 Tie2 Mus musculus (Mouse) TR16155_c0_g2_i1 Q06807 TIE2_BOVIN 3.00E-07 GO:0005524; GO:0048014; GO:0005884; GO:0016324; GO:0009925; GO:0009986; GO:0005911; GO:0005737; GO:0001935; GO:0005576; GO:0005925; GO:0060347; GO:0005887; GO:0045121; GO:0005902; GO:0016525; GO:2000352; GO:0070374; GO:2000251; GO:0045766; GO:0010595; GO:0051894; GO:0043552; GO:0014068; GO:0051897; GO:0001934; GO:0046777; GO:0051259; GO:0004713; GO:0032878; GO:0002040; GO:0001725; GO:0034446; GO:0004714 ATP binding; Tie signaling pathway; actin filament; apical plasma membrane; basal plasma membrane; cell surface; cell-cell junction; cytoplasm; endothelial cell proliferation; extracellular region; focal adhesion; heart trabecula formation; integral to plasma membrane; membrane raft; microvillus; negative regulation of angiogenesis; negative regulation of endothelial cell apoptotic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of actin cytoskeleton reorganization; positive regulation of angiogenesis; positive regulation of endothelial cell migration; positive regulation of focal adhesion assembly; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of protein phosphorylation; protein autophosphorylation; protein oligomerization; protein tyrosine kinase activity; regulation of establishment or maintenance of cell polarity; sprouting angiogenesis; stress fiber; substrate adhesion-dependent cell spreading; transmembrane receptor protein tyrosine kinase activity IPR000742; IPR013032; IPR002049; IPR003961; IPR007110; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR018941; IPR008266; IPR020635; Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TIE-2) (CD antigen CD202b) TEK TIE-2 TIE2 Bos taurus (Bovine) TR16155_c2_g1_i1 Q14162 SREC_HUMAN 4.00E-07 GO:0007155; GO:0006707; GO:0016358; GO:0030666; GO:0016021; GO:0030169; GO:0016322; GO:0005886; GO:0048680; GO:0005044; GO:0004888 cell adhesion; cholesterol catabolic process; dendrite development; endocytic vesicle membrane; integral to membrane; low-density lipoprotein particle binding; neuron remodeling; plasma membrane; positive regulation of axon regeneration; scavenger receptor activity; transmembrane signaling receptor activity IPR000742; IPR013032; IPR002049; IPR009030; Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) TR16170_c0_g1_i1 Q9ET47 ESPN_MOUSE 3.00E-06 GO:0017124; GO:0051015; GO:0051639; GO:0005903; GO:0030054; GO:0005737; GO:0043197; GO:0031941; GO:0007626; GO:0051494; GO:0030046; GO:0051491; GO:0007605; GO:0032420; GO:0032426 SH3 domain binding; actin filament binding; actin filament network formation; brush border; cell junction; cytoplasm; dendritic spine; filamentous actin; locomotory behavior; negative regulation of cytoskeleton organization; parallel actin filament bundle assembly; positive regulation of filopodium assembly; sensory perception of sound; stereocilium; stereocilium bundle tip IPR002110; IPR020683; IPR003124; Espin (Ectoplasmic specialization protein) Espn Mus musculus (Mouse) TR16170_c1_g1_i1 Q60J38 ANKHM_CAEBR 6.00E-06 GO:0003723; GO:0005737 RNA binding; cytoplasm IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat and KH domain-containing protein CBG24701 CBG24701 Caenorhabditis briggsae TR16173_c0_g1_i1 Q0EEE2 PTHD3_MOUSE 5.00E-46 GO:0008158; GO:0016021 hedgehog receptor activity; integral to membrane IPR003392; IPR000731; Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) TR16174_c0_g1_i1 P04157 PTPRC_RAT 3.00E-17 GO:0030183; GO:0042100; GO:0050853; GO:0030217; GO:0042098; GO:0050852; GO:0000187; GO:0048539; GO:0009986; GO:0051607; GO:0009897; GO:0005925; GO:0002244; GO:0008201; GO:0034113; GO:0002378; GO:0005887; GO:0009898; GO:0007159; GO:0045121; GO:0001915; GO:0006933; GO:0001960; GO:0050732; GO:0031953; GO:0006469; GO:0045060; GO:0030890; GO:0001916; GO:0042102; GO:0046641; GO:0050857; GO:0043065; GO:0045588; GO:2000473; GO:0002925; GO:0048304; GO:2000648; GO:0045059; GO:0019901; GO:0019887; GO:0045577; GO:0050855; GO:0051726; GO:0051209; GO:0010332; GO:0048864; GO:0005001 B cell differentiation; B cell proliferation; B cell receptor signaling pathway; T cell differentiation; T cell proliferation; T cell receptor signaling pathway; activation of MAPK activity; bone marrow development; cell surface; defense response to virus; external side of plasma membrane; focal adhesion; hematopoietic progenitor cell differentiation; heparin binding; heterotypic cell-cell adhesion; immunoglobulin biosynthetic process; integral to plasma membrane; internal side of plasma membrane; leukocyte cell-cell adhesion; membrane raft; negative regulation of T cell mediated cytotoxicity; negative regulation of cell adhesion involved in substrate-bound cell migration; negative regulation of cytokine-mediated signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein autophosphorylation; negative regulation of protein kinase activity; negative thymic T cell selection; positive regulation of B cell proliferation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of alpha-beta T cell proliferation; positive regulation of antigen receptor-mediated signaling pathway; positive regulation of apoptotic process; positive regulation of gamma-delta T cell differentiation; positive regulation of hematopoietic stem cell migration; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of isotype switching to IgG isotypes; positive regulation of stem cell proliferation; positive thymic T cell selection; protein kinase binding; protein kinase regulator activity; regulation of B cell differentiation; regulation of B cell receptor signaling pathway; regulation of cell cycle; release of sequestered calcium ion into cytosol; response to gamma radiation; stem cell development; transmembrane receptor protein tyrosine phosphatase activity IPR003961; IPR013783; IPR016335; IPR024739; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45) Ptprc Rattus norvegicus (Rat) TR16177_c1_g1_i1 Q8JFN7 ACH91_ONCMY 3.00E-25 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-9-I (Nicotinic acetylcholine receptor subunit alpha-9-I) (NACHR alpha-9-I) nachra9 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR16182_c0_g1_i1 P17437 XP2_XENLA 6.00E-20 GO:0005576 extracellular region IPR000519; IPR017994; IPR017957; Skin secretory protein xP2 (Protein APEG) p2 Xenopus laevis (African clawed frog) TR1619_c0_g1_i1 Q9D309 FAM3B_MOUSE 2.00E-06 GO:0006915; GO:0005125; GO:0005576; GO:0005615; GO:0030073; GO:0005641 apoptotic process; cytokine activity; extracellular region; extracellular space; insulin secretion; nuclear envelope lumen IPR026101; Protein FAM3B (Cytokine-like protein 2-21) (Pancreatic-derived factor) (PANDER) Fam3b ORF9 Mus musculus (Mouse) TR16199_c0_g2_i1 Q9UKP4 ATS7_HUMAN 7.00E-06 GO:0009986; GO:0004222; GO:0008237; GO:0005578; GO:0006508; GO:0008270 cell surface; metalloendopeptidase activity; metallopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS 7) (ADAM-TS7) (ADAMTS-7) (EC 3.4.24.-) (COMPase) ADAMTS7 Homo sapiens (Human) TR16201_c1_g1_i1 Q6NSJ0 K1161_HUMAN 1.00E-28 GO:0005975; GO:0004553; GO:0016021; GO:0031965; GO:0043568; GO:0051897; GO:0048741 "carbohydrate metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; integral to membrane; nuclear membrane; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of protein kinase B signaling cascade; skeletal muscle fiber development" IPR013785; IPR000322; IPR017853; Uncharacterized family 31 glucosidase KIAA1161 (EC 3.2.1.-) KIAA1161 Homo sapiens (Human) TR16209_c0_g1_i1 Q9ES30 C1QT3_MOUSE 2.00E-09 GO:0005581; GO:0005615; GO:0042593; GO:0042802; GO:0045721; GO:0070374; GO:0070165; GO:0050715; GO:0051897; GO:0051259 collagen; extracellular space; glucose homeostasis; identical protein binding; negative regulation of gluconeogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of adiponectin secretion; positive regulation of cytokine secretion; positive regulation of protein kinase B signaling cascade; protein oligomerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1qtnf3 Cors26 Ctrp3 Mus musculus (Mouse) TR1621_c0_g1_i1 Q8TD57 DYH3_HUMAN 3.00E-30 GO:0005524; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR026983; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 3, axonemal (Axonemal beta dynein heavy chain 3) (HsADHC3) (Ciliary dynein heavy chain 3) (Dnahc3-b)" DNAH3 DNAHC3B Homo sapiens (Human) TR16210_c0_g1_i1 P35398 RORA_HUMAN 1.00E-26 GO:0046068; GO:0021702; GO:0004879; GO:0006809; GO:0005654; GO:0045944; GO:0043030; GO:0043565; GO:0003707; GO:0006367; GO:0008270 P51843 cGMP metabolic process; cerebellar Purkinje cell differentiation; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nitric oxide biosynthetic process; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; regulation of macrophage activation; sequence-specific DNA binding; steroid hormone receptor activity; transcription initiation from RNA polymerase II promoter; zinc ion binding IPR008946; IPR000536; IPR003079; IPR001723; IPR001628; IPR013088; Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (Retinoid-related orphan receptor-alpha) RORA NR1F1 RZRA Homo sapiens (Human) TR16212_c0_g1_i1 Q5DTZ0 NYNRI_MOUSE 3.00E-07 GO:0015074; GO:0016021; GO:0003676 DNA integration; integral to membrane; nucleic acid binding IPR001584; IPR021869; IPR012337; Protein NYNRIN (NYN domain and retroviral integrase catalytic domain-containing protein) (Pol-like protein) Nynrin Kiaa1305 Mus musculus (Mouse) TR16221_c0_g1_i2 Q9NZM3 ITSN2_HUMAN 2.00E-09 GO:0005089; GO:0005070; GO:0005509; GO:0005737; GO:0006897; GO:0005543; GO:0035023 Q9WNA9 Rho guanyl-nucleotide exchange factor activity; SH3/SH2 adaptor activity; calcium ion binding; cytoplasm; endocytosis; phospholipid binding; regulation of Rho protein signal transduction IPR000008; IPR000219; IPR011992; IPR018247; IPR002048; IPR000261; IPR027029; IPR000108; IPR011993; IPR001849; IPR011511; IPR001452; Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) ITSN2 KIAA1256 SH3D1B SWAP Homo sapiens (Human) TR16224_c0_g1_i1 A7HHM9 URED_ANADF 1.00E-31 GO:0005737; GO:0016151; GO:0006807 cytoplasm; nickel cation binding; nitrogen compound metabolic process IPR002669; Urease accessory protein UreD ureD Anae109_4047 Anaeromyxobacter sp. (strain Fw109-5) TR16227_c0_g1_i1 Q9Z2J0 S23A1_MOUSE 4.00E-26 GO:0008520; GO:0016324; GO:0009925; GO:0007420; GO:0005903; GO:0005737; GO:0033300; GO:0016021; GO:0043229; GO:0030324; GO:0009636; GO:0070890; GO:0070904 L-ascorbate:sodium symporter activity; apical plasma membrane; basal plasma membrane; brain development; brush border; cytoplasm; dehydroascorbic acid transporter activity; integral to membrane; intracellular organelle; lung development; response to toxic substance; sodium-dependent L-ascorbate transmembrane transporter activity; transepithelial L-ascorbic acid transport IPR006043; Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (Yolk sac permease-like molecule 3) Slc23a1 Svct1 Yspl3 Mus musculus (Mouse) TR16235_c1_g1_i1 Q2HJ10 ZNT2_MOUSE 4.00E-36 GO:0008324; GO:0016021; GO:0005774; GO:0006829 cation transmembrane transporter activity; integral to membrane; vacuolar membrane; zinc ion transport IPR002524; IPR027469; Zinc transporter 2 (ZnT-2) (Solute carrier family 30 member 2) Slc30a2 Znt2 Mus musculus (Mouse) TR16239_c2_g1_i1 Q3UVK0 ERMP1_MOUSE 2.00E-08 GO:0005789; GO:0016021; GO:0046872; GO:0008237; GO:0006508 endoplasmic reticulum membrane; integral to membrane; metal ion binding; metallopeptidase activity; proteolysis IPR007484; Endoplasmic reticulum metallopeptidase 1 (EC 3.4.-.-) (Felix-ina) Ermp1 D19Wsu12e Fxna Kiaa1815 Mus musculus (Mouse) TR16240_c1_g1_i1 P35241 RADI_HUMAN 3.00E-74 GO:0051693; GO:0045177; GO:0045176; GO:0032154; GO:0005737; GO:0005856; GO:0019898; GO:0030175; GO:0030027; GO:0030033; GO:0005886; GO:0001726; GO:0032420 P05107 actin filament capping; apical part of cell; apical protein localization; cleavage furrow; cytoplasm; cytoskeleton; extrinsic to membrane; filopodium; lamellipodium; microvillus assembly; plasma membrane; ruffle; stereocilium IPR019749; IPR019750; IPR011174; IPR011259; IPR000798; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR008954; IPR011993; Radixin RDX Homo sapiens (Human) TR16242_c0_g1_i1 Q502M6 ANR29_DANRE 8.00E-12 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) TR16243_c0_g1_i1 Q56A06 TMTC2_MOUSE 4.00E-24 GO:0005783; GO:0016021 endoplasmic reticulum; integral to membrane IPR013618; IPR013026; IPR011990; IPR019734; Transmembrane and TPR repeat-containing protein 2 Tmtc2 Mus musculus (Mouse) TR16245_c0_g1_i1 Q40191 RB11A_LOTJA 8.00E-17 GO:0005525; GO:0005886; GO:0015031; GO:0007264 GTP binding; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab11A RAB11A Lotus japonicus (Lotus corniculatus var. japonicus) TR16245_c0_g2_i1 P16976 YPTM1_MAIZE 4.00E-22 GO:0005525; GO:0005886; GO:0015031; GO:0007264 GTP binding; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; GTP-binding protein YPTM1 YPTM1 Zea mays (Maize) TR1625_c0_g1_i1 P33527 MRP1_HUMAN 1.00E-41 GO:0005524; GO:0042626; GO:0005794; GO:0019369; GO:0009235; GO:0005887; GO:0006691; GO:0005634; GO:0042493 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; Golgi apparatus; arachidonic acid metabolic process; cobalamin metabolic process; integral to plasma membrane; leukotriene metabolic process; nucleus; response to drug" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP MRP1 Homo sapiens (Human) TR16255_c1_g2_i1 Q54QX0 CBPB_DICDI 8.00E-21 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calcium-binding protein B cbpB DDB_G0283533 Dictyostelium discoideum (Slime mold) TR16257_c0_g2_i1 P47237 PAX6_CHICK 3.00E-07 GO:0007275; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; Paired box protein Pax-6 (Fragment) PAX6 Gallus gallus (Chicken) TR16257_c0_g3_i1 O95076 ALX3_HUMAN 3.00E-07 GO:0035115; GO:0035116; GO:0048704; GO:0005634; GO:0007389; GO:0042981; GO:0043565; GO:0003700; GO:0006351 "embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic skeletal system morphogenesis; nucleus; pattern specification process; regulation of apoptotic process; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; Homeobox protein aristaless-like 3 (Proline-rich transcription factor ALX3) ALX3 Homo sapiens (Human) TR16258_c2_g1_i1 Q9Z2D5 NPY2R_CAVPO 1.00E-06 GO:0016021; GO:0004983; GO:0005886 integral to membrane; neuropeptide Y receptor activity; plasma membrane IPR000276; IPR017452; IPR001358; IPR000611; Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor) (Y2 receptor) NPY2R Cavia porcellus (Guinea pig) TR16265_c0_g1_i1 Q2KIR8 TDH_BOVIN 7.00E-140 GO:0008743; GO:0019518; GO:0050662; GO:0005739 L-threonine 3-dehydrogenase activity; L-threonine catabolic process to glycine; coenzyme binding; mitochondrion IPR001509; IPR016040; Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2. "L-threonine 3-dehydrogenase, mitochondrial (EC 1.1.1.103)" TDH Bos taurus (Bovine) TR16265_c0_g1_i2 Q4L3L8 Y2450_STAHJ 6.00E-86 GO:0003824; GO:0044237; GO:0050662 catalytic activity; cellular metabolic process; coenzyme binding IPR001509; IPR016040; Uncharacterized epimerase/dehydratase SH2450 SH2450 Staphylococcus haemolyticus (strain JCSC1435) TR16268_c1_g1_i1 Q5R9S5 ZN182_PONAB 6.00E-26 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 182 (Zinc finger protein 21) ZNF182 ZNF21 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR16268_c1_g1_i2 Q24732 GLAS_DROVI 2.00E-20 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0050896; GO:0006351; GO:0007601 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; response to stimulus; transcription, DNA-dependent; visual perception" IPR007087; IPR015880; IPR013087; Protein glass gl GJ10836 Drosophila virilis (Fruit fly) TR16269_c2_g1_i1 Q8R1Q3 ANGL7_MOUSE 7.00E-13 GO:0005576 extracellular region IPR014716; IPR014715; IPR002181; Angiopoietin-related protein 7 (Angiopoietin-like protein 7) Angptl7 Mus musculus (Mouse) TR16271_c0_g1_i1 Q9UBI1 COMD3_HUMAN 1.00E-45 Q8N668 IPR017920; IPR009886; COMM domain-containing protein 3 (Protein Bup) (Protein PIL) COMMD3 BUP C10orf8 Homo sapiens (Human) TR16276_c3_g1_i1 A6JUQ6 CLVS2_RAT 2.00E-41 GO:0005794; GO:0030136; GO:0031901; GO:0005768; GO:0007040; GO:0080025; GO:0005802; GO:0005215 "Golgi apparatus; clathrin-coated vesicle; early endosome membrane; endosome; lysosome organization; phosphatidylinositol-3,5-bisphosphate binding; trans-Golgi network; transporter activity" IPR001071; IPR001251; IPR011074; Clavesin-2 (Retinaldehyde-binding protein 1-like 2) Clvs2 Rlbp1l2 Rattus norvegicus (Rat) TR16281_c1_g1_i1 Q8BGS3 ZKSC1_MOUSE 8.00E-25 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein with KRAB and SCAN domains 1 Zkscan1 Mus musculus (Mouse) TR16281_c1_g1_i2 Q9QZ48 ZBT7A_RAT 6.00E-26 GO:0003677; GO:0030154; GO:0035035; GO:0046872; GO:0007275; GO:0045892; GO:0005634; GO:0045670; GO:0003700; GO:0006351 "DNA binding; cell differentiation; histone acetyltransferase binding; metal ion binding; multicellular organismal development; negative regulation of transcription, DNA-dependent; nucleus; regulation of osteoclast differentiation; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma-related factor) (Osteoclast-derived zinc finger protein) Zbtb7a Lrf Oczf Zbtb7 Rattus norvegicus (Rat) TR16281_c1_g1_i3 Q14590 ZN235_HUMAN 8.00E-45 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) TR16284_c0_g1_i1 Q9PU36 PCLO_CHICK 2.00E-06 GO:0005509; GO:0005544; GO:0030054; GO:0007010; GO:0005522; GO:0045202 calcium ion binding; calcium-dependent phospholipid binding; cell junction; cytoskeleton organization; profilin binding; synapse IPR000008; IPR001478; IPR011011; IPR008899; IPR013083; Protein piccolo (Aczonin) (Fragment) PCLO ACZ Gallus gallus (Chicken) TR16284_c1_g2_i1 Q86YS7 K0528_HUMAN 3.00E-41 GO:0005509; GO:0005544; GO:0005938; GO:0030659; GO:0038028; GO:0065002; GO:2001275; GO:0010828; GO:0090314; GO:0031340; GO:0072659; GO:0032587; GO:0006906 calcium ion binding; calcium-dependent phospholipid binding; cell cortex; cytoplasmic vesicle membrane; insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade; intracellular protein transmembrane transport; positive regulation of glucose import in response to insulin stimulus; positive regulation of glucose transport; positive regulation of protein targeting to membrane; positive regulation of vesicle fusion; protein localization to plasma membrane; ruffle membrane; vesicle fusion IPR000008; C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa) C2CD5 CDP138 KIAA0528 Homo sapiens (Human) TR16288_c1_g1_i1 Q61656 DDX5_MOUSE 4.00E-129 GO:0005524; GO:0008026; GO:0003723; GO:0003724; GO:0008380; GO:0050681; GO:0007623; GO:0030331; GO:0001701; GO:0072332; GO:0006397; GO:0000122; GO:0005730; GO:0043517; GO:0045944; GO:0000381; GO:0060765; GO:0045667; GO:2001014; GO:0030529; GO:0005681; GO:0003713; GO:0006351 "ATP binding; ATP-dependent helicase activity; RNA binding; RNA helicase activity; RNA splicing; androgen receptor binding; circadian rhythm; estrogen receptor binding; in utero embryonic development; intrinsic apoptotic signaling pathway by p53 class mediator; mRNA processing; negative regulation of transcription from RNA polymerase II promoter; nucleolus; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of transcription from RNA polymerase II promoter; regulation of alternative mRNA splicing, via spliceosome; regulation of androgen receptor signaling pathway; regulation of osteoblast differentiation; regulation of skeletal muscle cell differentiation; ribonucleoprotein complex; spliceosomal complex; transcription coactivator activity; transcription, DNA-dependent" IPR011545; IPR014001; IPR001650; IPR027417; IPR012587; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box RNA helicase DEAD1) (mDEAD1) (DEAD box protein 5) (RNA helicase p68) Ddx5 Tnz2 Mus musculus (Mouse) TR16288_c2_g2_i1 Q6FJG1 FAL1_CANGA 3.00E-27 GO:0005524; GO:0008026; GO:0003723; GO:0005730; GO:0006364 ATP binding; ATP-dependent helicase activity; RNA binding; nucleolus; rRNA processing IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase FAL1 (EC 3.6.4.13) FAL1 CAGL0M06567g Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) TR16289_c1_g1_i1 Q96Q27 ASB2_HUMAN 5.00E-09 GO:0031466; GO:0035556; GO:0045445; GO:0000209; GO:0042787; GO:0007165; GO:0035914; GO:0004842 Q93034; Q9UBF6 Cul5-RING ubiquitin ligase complex; intracellular signal transduction; myoblast differentiation; protein polyubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; signal transduction; skeletal muscle cell differentiation; ubiquitin-protein ligase activity IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 2 (ASB-2) ASB2 Homo sapiens (Human) TR16289_c1_g2_i1 Q86YR6 POTED_HUMAN 4.00E-08 GO:0005886 plasma membrane IPR002110; IPR020683; "POTE ankyrin domain family member D (ANKRD26-like family B member 3) (Ankyrin repeat domain-containing protein 21) (Prostate, ovary, testis-expressed protein) (Protein POTE)" POTED A26B3 ANKRD21 POTE Homo sapiens (Human) TR16297_c1_g1_i1 Q9NZJ4 SACS_HUMAN 3.00E-26 GO:0005524; GO:0030424; GO:0070852; GO:0008219; GO:0051087; GO:0030425; GO:0005739; GO:0090084; GO:0005634; GO:0006457 ATP binding; axon; cell body fiber; cell death; chaperone binding; dendrite; mitochondrion; negative regulation of inclusion body assembly; nucleus; protein folding IPR001623; IPR003594; IPR007842; IPR000626; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) TR16299_c0_g1_i1 Q28E45 MCM10_XENTR 2.00E-43 GO:0003677; GO:0006260; GO:0046872; GO:0005634 DNA binding; DNA replication; metal ion binding; nucleus IPR015411; IPR015408; Protein MCM10 homolog mcm10 TEgg053h10.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR16300_c1_g1_i1 Q9C0G6 DYH6_HUMAN 5.00E-15 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 6, axonemal (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6)" DNAH6 DNAHC6 DNHL1 HL2 KIAA1697 Homo sapiens (Human) TR16300_c1_g2_i1 Q8TD57 DYH3_HUMAN 2.00E-29 GO:0005524; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR026983; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 3, axonemal (Axonemal beta dynein heavy chain 3) (HsADHC3) (Ciliary dynein heavy chain 3) (Dnahc3-b)" DNAH3 DNAHC3B Homo sapiens (Human) TR16302_c0_g1_i1 Q9NBX4 RTXE_DROME 6.00E-11 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR16305_c0_g1_i2 Q923L3 CSMD1_MOUSE 8.00E-06 GO:0016021 integral to membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 1 (CUB and sushi multiple domains protein 1) Csmd1 Mus musculus (Mouse) TR16308_c0_g1_i1 Q9BQS8 FYCO1_HUMAN 4.00E-13 GO:0005776; GO:0031410; GO:0016021; GO:0005770; GO:0005764; GO:0046872; GO:0072383 O95166; Q9H0R8; P60520; O60341; Q9GZQ8; Q9BXW4; Q96LA8 autophagic vacuole; cytoplasmic vesicle; integral to membrane; late endosome; lysosome; metal ion binding; plus-end-directed vesicle transport along microtubule IPR009038; IPR004012; IPR000306; IPR017455; IPR011011; IPR013083; FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) FYCO1 ZFYVE7 Homo sapiens (Human) TR16311_c0_g1_i1 P46436 GST1_ASCSU 1.00E-30 GO:0004364 glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase 1 (EC 2.5.1.18) (GST class-sigma) GST1 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) TR16312_c0_g1_i1 A7MBB8 DOK2_BOVIN 1.00E-07 GO:0007265; GO:0005543; GO:0005057; GO:0007169 Ras protein signal transduction; phospholipid binding; receptor signaling protein activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR002404; IPR011993; IPR001849; Docking protein 2 (Downstream of tyrosine kinase 2) DOK2 Bos taurus (Bovine) TR16313_c7_g1_i1 Q96JH7 VCIP1_HUMAN 2.00E-32 GO:0090168; GO:0005795; GO:0005737; GO:0005783; GO:0016320; GO:0007067; GO:0035871; GO:0071108; GO:0016567; GO:0006508; GO:0004843 Golgi reassembly; Golgi stack; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane fusion; mitosis; protein K11-linked deubiquitination; protein K48-linked deubiquitination; protein ubiquitination; proteolysis; ubiquitin-specific protease activity IPR003323; Deubiquitinating protein VCIP135 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) VCPIP1 KIAA1850 VCIP135 Homo sapiens (Human) TR16314_c1_g1_i1 Q8WYQ3 CHC10_HUMAN 6.00E-10 GO:0006754; GO:0005739; GO:2000984; GO:0006119 ATP biosynthetic process; mitochondrion; negative regulation of ATP citrate synthase activity; oxidative phosphorylation IPR010625; "Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial (Protein N27C7-4)" CHCHD10 C22orf16 Homo sapiens (Human) TR16322_c0_g1_i1 Q9Y2I7 FYV1_HUMAN 8.00E-17 GO:0000285; GO:0016308; GO:0005524; GO:0000139; GO:0044267; GO:0031410; GO:0005829; GO:0031901; GO:0035556; GO:0031902; GO:0045121; GO:0046872; GO:0032288; GO:0048471; GO:0043813; GO:0034504; GO:0042147; GO:0044281 "1-phosphatidylinositol-3-phosphate 5-kinase activity; 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding; Golgi membrane; cellular protein metabolic process; cytoplasmic vesicle; cytosol; early endosome membrane; intracellular signal transduction; late endosome membrane; membrane raft; metal ion binding; myelin assembly; perinuclear region of cytoplasm; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; protein localization to nucleus; retrograde transport, endosome to Golgi; small molecule metabolic process" IPR002423; IPR000591; IPR027409; IPR027483; IPR002498; IPR027484; IPR016034; IPR027410; IPR011991; IPR000306; IPR017455; IPR011011; IPR013083; 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) PIKFYVE KIAA0981 PIP5K3 Homo sapiens (Human) TR16330_c5_g1_i1 Q9R0E0 CEGT_RAT 5.00E-12 GO:0000139; GO:0008120; GO:0016021; GO:0006665 Golgi membrane; ceramide glucosyltransferase activity; integral to membrane; sphingolipid metabolic process IPR025993; Lipid metabolism; sphingolipid metabolism. Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase) Ugcg Rattus norvegicus (Rat) TR16334_c1_g1_i1 P20483 MPIP_DROME 3.00E-40 GO:0000086; GO:0007030; GO:0051301; GO:0008283; GO:0007099; GO:0005694; GO:0007369; GO:0046331; GO:0007498; GO:0007067; GO:0045792; GO:0045930; GO:0005634; GO:0007424; GO:0007422; GO:0008284; GO:0045977; GO:0004725; GO:0008138; GO:0060305 "G2/M transition of mitotic cell cycle; Golgi organization; cell division; cell proliferation; centriole replication; chromosome; gastrulation; lateral inhibition; mesoderm development; mitosis; negative regulation of cell size; negative regulation of mitotic cell cycle; nucleus; open tracheal system development; peripheral nervous system development; positive regulation of cell proliferation; positive regulation of mitotic cell cycle, embryonic; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; regulation of cell diameter" IPR000751; IPR001763; M-phase inducer phosphatase (EC 3.1.3.48) (Cdc25-like protein) (Protein string) stg cdc25 CG1395 Drosophila melanogaster (Fruit fly) TR16335_c0_g1_i1 Q99PV8 BC11B_MOUSE 5.00E-09 GO:0000978; GO:0001077; GO:0033077; GO:0033153; GO:0046632; GO:0003382; GO:0003334; GO:0046872; GO:0043066; GO:0008285; GO:0005634; GO:0042475; GO:0071678; GO:0043368; GO:0031077; GO:0010837; GO:0019216; GO:0045664; GO:0021773; GO:0048538 RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; T cell differentiation in thymus; T cell receptor V(D)J recombination; alpha-beta T cell differentiation; epithelial cell morphogenesis; keratinocyte development; metal ion binding; negative regulation of apoptotic process; negative regulation of cell proliferation; nucleus; odontogenesis of dentin-containing tooth; olfactory bulb axon guidance; positive T cell selection; post-embryonic camera-type eye development; regulation of keratinocyte proliferation; regulation of lipid metabolic process; regulation of neuron differentiation; striatal medium spiny neuron differentiation; thymus development IPR007087; IPR015880; IPR013087; B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (mRit1) Bcl11b Ctip2 Rit1 Mus musculus (Mouse) TR16335_c0_g2_i1 Q9UL36 ZN236_HUMAN 2.00E-15 GO:0003677; GO:0071333; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; cellular response to glucose stimulus; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 236 ZNF236 Homo sapiens (Human) TR16338_c0_g1_i1 P50476 HOX3_XENLA 3.00E-35 GO:0007275; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein XHOX-3 xhox3 Xenopus laevis (African clawed frog) TR16341_c1_g2_i1 O75899 GABR2_HUMAN 9.00E-28 GO:0004965; GO:0038039; GO:0030054; GO:0005737; GO:0007214; GO:0005887; GO:0007194; GO:0043005; GO:0045211; GO:0007268 P46459 G-protein coupled GABA receptor activity; G-protein coupled receptor heterodimeric complex; cell junction; cytoplasm; gamma-aminobutyric acid signaling pathway; integral to plasma membrane; negative regulation of adenylate cyclase activity; neuron projection; postsynaptic membrane; synaptic transmission IPR001828; IPR000337; IPR017978; IPR017979; IPR002455; IPR002457; IPR028082; Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20) GABBR2 GPR51 GPRC3B Homo sapiens (Human) TR16344_c0_g1_i1 Q9HCK4 ROBO2_HUMAN 2.00E-07 GO:0061364; GO:0030673; GO:0008046; GO:0016199; GO:0009986; GO:0032870; GO:0007156; GO:0042802; GO:0016021; GO:0001656; GO:0050925; GO:0051964; GO:0021891; GO:0050772; GO:0031290; GO:0001657 apoptotic process involved in luteolysis; axolemma; axon guidance receptor activity; axon midline choice point recognition; cell surface; cellular response to hormone stimulus; homophilic cell adhesion; identical protein binding; integral to membrane; metanephros development; negative regulation of negative chemotaxis; negative regulation of synapse assembly; olfactory bulb interneuron development; positive regulation of axonogenesis; retinal ganglion cell axon guidance; ureteric bud development IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; Roundabout homolog 2 ROBO2 KIAA1568 Homo sapiens (Human) TR16345_c1_g1_i1 P61374 ISL1_RAT 3.00E-75 GO:0001105; GO:0060413; GO:0031103; GO:0060913; GO:0003215; GO:0071385; GO:0003203; GO:0001158; GO:0030331; GO:0060384; GO:0016922; GO:0050728; GO:0033147; GO:0043524; GO:0090074; GO:0000122; GO:0048665; GO:0005634; GO:0003148; GO:0048936; GO:0060037; GO:0045766; GO:0071657; GO:0032725; GO:0032024; GO:0032729; GO:0032730; GO:0032731; GO:0032735; GO:0032755; GO:0045944; GO:0032760; GO:0010575; GO:0003139; GO:0048880; GO:0043565; GO:0003700; GO:0021559; GO:0055010; GO:0008270 RNA polymerase II transcription coactivator activity; atrial septum morphogenesis; axon regeneration; cardiac cell fate determination; cardiac right ventricle morphogenesis; cellular response to glucocorticoid stimulus; endocardial cushion morphogenesis; enhancer sequence-specific DNA binding; estrogen receptor binding; innervation; ligand-dependent nuclear receptor binding; negative regulation of inflammatory response; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of neuron apoptotic process; negative regulation of protein homodimerization activity; negative regulation of transcription from RNA polymerase II promoter; neuron fate specification; nucleus; outflow tract septum morphogenesis; peripheral nervous system neuron axonogenesis; pharyngeal system development; positive regulation of angiogenesis; positive regulation of granulocyte colony-stimulating factor production; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of insulin secretion; positive regulation of interferon-gamma production; positive regulation of interleukin-1 alpha production; positive regulation of interleukin-1 beta production; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; positive regulation vascular endothelial growth factor production; secondary heart field specification; sensory system development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; trigeminal nerve development; ventricular cardiac muscle tissue morphogenesis; zinc ion binding IPR017970; IPR001356; IPR009057; IPR001781; Insulin gene enhancer protein ISL-1 (Islet-1) Isl1 Rattus norvegicus (Rat) TR16345_c3_g1_i1 P53407 ISL2B_DANRE 4.00E-37 GO:0007275; GO:0005634; GO:0043565; GO:0003700; GO:0008270 multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; zinc ion binding IPR017970; IPR001356; IPR009057; IPR001781; Insulin gene enhancer protein isl-2b (Islet-2B) (Insulin gene enhancer protein isl-3) (Islet-3) isl2b isl-3 isl3 zgc:109840 Danio rerio (Zebrafish) (Brachydanio rerio) TR16348_c0_g1_i1 P46088 GST_OMMSL 1.00E-41 GO:0005737; GO:0004364 cytoplasm; glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR003083; IPR012336; Glutathione S-transferase (EC 2.5.1.18) (GST class-sigma) Ommastrephes sloanei (Arrow squid) (Sloane's squid) TR16372_c0_g1_i1 Q63921 PGH1_RAT 2.00E-12 GO:0007568; GO:0005737; GO:0051213; GO:0005789; GO:0020037; GO:0007612; GO:0008289; GO:0035633; GO:0007613; GO:0046872; GO:0032811; GO:0010700; GO:0005635; GO:0004601; GO:0045987; GO:0045907; GO:0001516; GO:0004666; GO:0008217; GO:0051412; GO:0070542; GO:0010243; GO:0006979; GO:0019233 aging; cytoplasm; dioxygenase activity; endoplasmic reticulum membrane; heme binding; learning; lipid binding; maintenance of blood-brain barrier; memory; metal ion binding; negative regulation of epinephrine secretion; negative regulation of norepinephrine secretion; nuclear envelope; peroxidase activity; positive regulation of smooth muscle contraction; positive regulation of vasoconstriction; prostaglandin biosynthetic process; prostaglandin-endoperoxide synthase activity; regulation of blood pressure; response to corticosterone stimulus; response to fatty acid; response to organonitrogen compound; response to oxidative stress; sensory perception of pain IPR000742; IPR010255; IPR002007; IPR019791; Lipid metabolism; prostaglandin biosynthesis. Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1) Ptgs1 Cox-1 Cox1 Rattus norvegicus (Rat) TR16383_c0_g1_i1 Q3V1M1 IGS10_MOUSE 1.00E-17 GO:0005576; GO:0001503 extracellular region; ossification IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Immunoglobulin superfamily member 10 (IgSF10) Igsf10 Mus musculus (Mouse) TR16394_c0_g1_i1 A9ULZ2 BIR7B_XENLA 5.00E-11 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) TR16394_c2_g1_i1 P41437 IAP3_NPVOP 4.00E-15 GO:0006915; GO:0016874; GO:0039648; GO:0008270 apoptotic process; ligase activity; modulation by virus of host protein ubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; E3 ubiquitin-protein ligase IAP-3 (EC 6.3.2.-) (IAP-3) IAP3 IAP ORF35 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) TR16394_c2_g2_i1 O62640 PIAP_PIG 9.00E-17 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR16397_c0_g1_i1 Q94IW5 C90D2_ORYSJ 5.00E-20 GO:0016132; GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705 "brassinosteroid biosynthetic process; heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Plant hormone biosynthesis; brassinosteroid biosynthesis. Cytochrome P450 90D2 (EC 1.14.-.-) (C6-oxidase) CYP90D2 D2 Os01g0197100 LOC_Os01g10040 P0419B01.11 Oryza sativa subsp. japonica (Rice) TR16401_c1_g1_i1 Q9NXG0 CNTLN_HUMAN 3.00E-23 GO:0005814; GO:0005813; GO:0016020; GO:0005739; GO:0000155; GO:0000160; GO:0023014 centriole; centrosome; membrane; mitochondrion; phosphorelay sensor kinase activity; phosphorelay signal transduction system; signal transduction by phosphorylation IPR003661; Centlein (Centrosomal protein) CNTLN C9orf101 C9orf39 Homo sapiens (Human) TR16404_c0_g1_i1 Q8IZJ3 CPMD8_HUMAN 2.00E-27 GO:0005615; GO:0010951; GO:0005886; GO:0004867 extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR002350; IPR001599; IPR019742; IPR019565; IPR022041; IPR008930; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 CPAMD8 KIAA1283 Homo sapiens (Human) TR16408_c0_g2_i1 Q91X17 UROM_MOUSE 7.00E-08 GO:0031225; GO:0016324; GO:0016323; GO:0005509; GO:0048878; GO:0060170; GO:0007588; GO:0005576; GO:0072218; GO:0072221; GO:0072233; GO:0072372; GO:2000021; GO:0000922 anchored to membrane; apical plasma membrane; basolateral plasma membrane; calcium ion binding; chemical homeostasis; cilium membrane; excretion; extracellular region; metanephric ascending thin limb development; metanephric distal convoluted tubule development; metanephric thick ascending limb development; primary cilium; regulation of ion homeostasis; spindle pole IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR023413; IPR009030; IPR001507; IPR017977; "Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]" Umod Mus musculus (Mouse) TR16408_c0_g3_i1 P25291 GP2_CANFA 2.00E-11 GO:0031225; GO:0005576; GO:0005886 anchored to membrane; extracellular region; plasma membrane IPR001507; IPR017977; Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) GP2 Canis familiaris (Dog) (Canis lupus familiaris) TR16411_c0_g1_i1 B5X3W7 CTL2_SALSA 2.00E-44 GO:0016021; GO:0006810 integral to membrane; transport IPR007603; Choline transporter-like protein 2 (Solute carrier family 44 member 2) slc44a2 ctl2 Salmo salar (Atlantic salmon) TR16419_c1_g1_i1 A9JTP3 BIRC7_XENTR 1.00E-07 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP) (Embryonic/Egg IAP) (EIAP/XLX) birc7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR1642_c0_g1_i1 Q02372 NDUB8_BOVIN 4.00E-46 GO:0008137; GO:0016021; GO:0006120; GO:0005747 "NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I" IPR016551; IPR008699; "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (Complex I-ASHI) (CI-ASHI) (NADH-ubiquinone oxidoreductase ASHI subunit)" NDUFB8 Bos taurus (Bovine) TR16425_c1_g1_i1 P18172 DHGL_DROPS 8.00E-26 GO:0006066; GO:0008812; GO:0005576; GO:0050660 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR16426_c1_g1_i1 P02587 TNNC2_PIG 2.00E-07 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; "Troponin C, skeletal muscle" TNNC2 Sus scrofa (Pig) TR16428_c0_g1_i1 O60268 K0513_HUMAN 1.00E-22 GO:0005737 cytoplasm Uncharacterized protein KIAA0513 KIAA0513 Homo sapiens (Human) TR16434_c0_g1_i1 Q9TU71 ANKR1_RABIT 2.00E-20 GO:0005634 nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 1 (Cardiac adriamycin-responsive protein) (Cardiac ankyrin repeat protein) ANKRD1 CARP Oryctolagus cuniculus (Rabbit) TR16434_c0_g2_i1 G5E8K5 ANK3_MOUSE 4.00E-42 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR16434_c1_g1_i1 Q9XZC0 LCTA_LATTR 4.00E-25 GO:0006887; GO:0016021; GO:0072556 exocytosis; integral to membrane; other organism presynaptic membrane IPR002110; IPR020683; IPR028047; Alpha-latrocrustotoxin-Lt1a (Alpha-LCT-Lt1a) (Alpha-latrocrustotoxin) (Alpha-LCT) (Crusta1) (Fragment) Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus) TR16434_c2_g1_i1 Q5UQY4 YR886_MIMIV 7.00E-09 IPR002110; IPR020683; Putative ankyrin repeat protein R886 (Fragment) MIMI_R886 Acanthamoeba polyphaga mimivirus (APMV) TR16446_c1_g1_i1 Q7TPV2 DZIP3_MOUSE 5.00E-07 GO:0003723; GO:0005737; GO:0016874; GO:0019902; GO:0016567; GO:0008270 RNA binding; cytoplasm; ligase activity; phosphatase binding; protein ubiquitination; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog) Dzip3 Kiaa0675 Mus musculus (Mouse) TR1645_c0_g1_i1 A0JNB1 ZN227_BOVIN 1.00E-27 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 227 ZNF227 Bos taurus (Bovine) TR16457_c2_g1_i1 O73694 EGR1_SERCA 7.00E-15 GO:0046872; GO:0005634; GO:0045893; GO:0043565; GO:0003700; GO:0006351 "metal ion binding; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Early growth response protein 1 (EGR-1) (Zinc finger protein ZENK) (Fragment) EGR1 ZENK Serinus canaria (Island canary) (Fringilla canaria) TR16457_c2_g1_i2 Q13887 KLF5_HUMAN 5.00E-53 GO:0003677; GO:0005794; GO:0001525; GO:0046872; GO:0030033; GO:0005634; GO:0045893; GO:0003700; GO:0035914; GO:0006366 P0CG48 "DNA binding; Golgi apparatus; angiogenesis; metal ion binding; microvillus assembly; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; skeletal muscle cell differentiation; transcription from RNA polymerase II promoter" IPR007087; IPR015880; IPR013087; Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2) KLF5 BTEB2 CKLF IKLF Homo sapiens (Human) TR16465_c2_g1_i1 O70277 TRIM3_RAT 4.00E-06 GO:0005737; GO:0005769; GO:0015031; GO:0008270 cytoplasm; early endosome; protein transport; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) TR16466_c1_g1_i1 Q8NHV1 GIMA7_HUMAN 5.00E-33 GO:0005525; GO:0003924; GO:0005811 GTP binding; GTPase activity; lipid particle IPR006703; IPR027417; GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) TR16468_c0_g1_i1 Q60928 GGT1_MOUSE 4.00E-27 GO:0071260; GO:0019344; GO:0003840; GO:0006536; GO:0006750; GO:0006751; GO:0036374; GO:0005887; GO:0060427; GO:0002682; GO:0050727; GO:0007283 cellular response to mechanical stimulus; cysteine biosynthetic process; gamma-glutamyltransferase activity; glutamate metabolic process; glutathione biosynthetic process; glutathione catabolic process; glutathione hydrolase activity; integral to plasma membrane; lung connective tissue development; regulation of immune system process; regulation of inflammatory response; spermatogenesis IPR000101; Sulfur metabolism; glutathione metabolism. Gamma-glutamyltranspeptidase 1 (GGT 1) (EC 2.3.2.2) (Gamma-glutamyltransferase 1) (Glutathione hydrolase 1) (EC 3.4.19.13) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Gamma-glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain] Ggt1 Ggt Ggtp Mus musculus (Mouse) TR16468_c4_g1_i1 P54422 GGT_BACSU 9.00E-12 GO:0005576; GO:0003840; GO:0006750; GO:0036374 extracellular region; gamma-glutamyltransferase activity; glutathione biosynthetic process; glutathione hydrolase activity IPR000101; Sulfur metabolism; glutathione metabolism. Gamma-glutamyltranspeptidase (EC 2.3.2.2) (Glutathione hydrolase) (EC 3.4.19.13) [Cleaved into: Gamma-glutamyltranspeptidase large chain; Gamma-glutamyltranspeptidase small chain] ggt BSU18410 Bacillus subtilis (strain 168) TR16468_c5_g1_i1 Q9BX51 GGTL1_HUMAN 1.00E-22 GO:0031362; GO:0003840; GO:0006749; GO:0019370 anchored to external side of plasma membrane; gamma-glutamyltransferase activity; glutathione metabolic process; leukotriene biosynthetic process IPR000101; Gamma-glutamyltransferase light chain 1 (Gamma-glutamyltransferase-like activity 4) (Gamma-glutamyltransferase-like protein 6) GGTLC1 GGTLA4 Homo sapiens (Human) TR16470_c0_g1_i1 Q0VFV7 KCTD7_DANRE 9.00E-08 GO:0005829; GO:0005886; GO:0051260 cytosol; plasma membrane; protein homooligomerization IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein KCTD7 kctd7 zgc:136884 Danio rerio (Zebrafish) (Brachydanio rerio) TR16471_c0_g1_i1 Q9ZSE4 PP2A_HEVBR 2.00E-57 GO:0005737; GO:0046872; GO:0004721 cytoplasm; metal ion binding; phosphoprotein phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP2A catalytic subunit (EC 3.1.3.16) PP2A Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis) TR16471_c2_g1_i1 P48463 PP2AA_CHICK 2.00E-54 GO:0000775; GO:0005737; GO:0046872; GO:0043066; GO:0005634; GO:0004721; GO:0043161; GO:0046982; GO:0000159; GO:0010468; GO:0046677; GO:0042542; GO:0000922 "chromosome, centromeric region; cytoplasm; metal ion binding; negative regulation of apoptotic process; nucleus; phosphoprotein phosphatase activity; proteasomal ubiquitin-dependent protein catabolic process; protein heterodimerization activity; protein phosphatase type 2A complex; regulation of gene expression; response to antibiotic; response to hydrogen peroxide; spindle pole" IPR004843; IPR006186; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) PPP2CA Gallus gallus (Chicken) TR16473_c0_g1_i1 Q96253 ATP5E_ARATH 6.00E-12 GO:0015986; GO:0005753; GO:0000275; GO:0046933; GO:0046961 "ATP synthesis coupled proton transport; mitochondrial proton-transporting ATP synthase complex; mitochondrial proton-transporting ATP synthase complex, catalytic core F(1); proton-transporting ATP synthase activity, rotational mechanism; proton-transporting ATPase activity, rotational mechanism" IPR006721; "ATP synthase subunit epsilon, mitochondrial (ATPase subunit epsilon)" At1g51650 F19C24.25 Arabidopsis thaliana (Mouse-ear cress) TR16477_c0_g1_i1 A7SMR0 MEIG1_NEMVE 2.00E-37 GO:0005634 nucleus IPR020186; Meiosis expressed gene 1 protein homolog v1g237368 Nematostella vectensis (Starlet sea anemone) TR16478_c0_g1_i1 Q8TGM7 ART2_YEAST 7.00E-16 Putative uncharacterized protein ART2 (Antisense to ribosomal RNA transcript protein 2) ART2 YLR154W-A YLR154W-C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR16491_c0_g1_i1 Q5ZII6 KISHA_CHICK 8.00E-27 GO:0000139; GO:0016021 Golgi membrane; integral to membrane IPR009653; Protein kish-A (Transmembrane protein 167) (Transmembrane protein 167A) TMEM167A TMEM167 RCJMB04_25n4 Gallus gallus (Chicken) TR16494_c3_g1_i1 P33450 FAT_DROME 8.00E-09 GO:0005509; GO:0016339; GO:0050839; GO:0030054; GO:0000904; GO:0008283; GO:0045317; GO:0048105; GO:0045198; GO:0001737; GO:0035329; GO:0007156; GO:0007446; GO:0005887; GO:0090176; GO:0030178; GO:0008285; GO:0045571; GO:0016318; GO:0018149; GO:0004872; GO:0035159 "calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; cell junction; cell morphogenesis involved in differentiation; cell proliferation; equator specification; establishment of body hair planar orientation; establishment of epithelial cell apical/basal polarity; establishment of imaginal disc-derived wing hair orientation; hippo signaling cascade; homophilic cell adhesion; imaginal disc growth; integral to plasma membrane; microtubule cytoskeleton organization involved in establishment of planar polarity; negative regulation of Wnt receptor signaling pathway; negative regulation of cell proliferation; negative regulation of imaginal disc growth; ommatidial rotation; peptide cross-linking; receptor activity; regulation of tube length, open tracheal system" IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR013032; IPR001791; Cadherin-related tumor suppressor (Protein fat) ft CG3352 Drosophila melanogaster (Fruit fly) TR16495_c0_g3_i1 Q8CHJ2 AQP12_MOUSE 5.00E-08 GO:0005737; GO:0016021; GO:0005215 cytoplasm; integral to membrane; transporter activity IPR023271; IPR016697; IPR023265; IPR000425; Aquaporin-12 (AQP-12) Aqp12 Mus musculus (Mouse) TR16501_c2_g1_i1 Q17R00 EMX2_BOVIN 2.00E-29 GO:0009952; GO:0021846; GO:0021796; GO:0021542; GO:0021885; GO:0030182; GO:0005634; GO:0072001; GO:0042493; GO:0003700; GO:0000976 anterior/posterior pattern specification; cell proliferation in forebrain; cerebral cortex regionalization; dentate gyrus development; forebrain cell migration; neuron differentiation; nucleus; renal system development; response to drug; sequence-specific DNA binding transcription factor activity; transcription regulatory region sequence-specific DNA binding IPR017970; IPR001356; IPR020479; IPR009057; IPR000047; Homeobox protein EMX2 (Empty spiracles homolog 2) (Empty spiracles-like protein 2) EMX2 Bos taurus (Bovine) TR16505_c1_g1_i1 Q02357 ANK1_MOUSE 2.00E-24 GO:0030863; GO:0048821; GO:0016020; GO:0015672; GO:0006779; GO:0016529; GO:0007165; GO:0014731 cortical cytoskeleton; erythrocyte development; membrane; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; sarcoplasmic reticulum; signal transduction; spectrin-associated cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) TR16507_c1_g1_i1 P62321 RUXF_XENLA 1.00E-24 GO:0003723; GO:0008380; GO:0006397; GO:0005681 RNA binding; RNA splicing; mRNA processing; spliceosomal complex IPR010920; IPR001163; IPR006649; IPR016487; Small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) (SmF) snrpf Xenopus laevis (African clawed frog) TR16508_c0_g1_i1 Q58094 TKTN_METJA 8.00E-15 GO:0046872; GO:0004802 metal ion binding; transketolase activity IPR005474; Putative transketolase N-terminal section (TK) (EC 2.2.1.1) MJ0681 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR16508_c3_g1_i1 Q60HC7 TKT_MACFA 1.00E-39 GO:0046872; GO:0004802 metal ion binding; transketolase activity IPR009014; IPR005475; IPR020826; IPR005476; IPR005474; Transketolase (TK) (EC 2.2.1.1) TKT QflA-15469 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR16510_c0_g1_i1 Q80WQ4 K1456_MOUSE 4.00E-17 GO:0008168 methyltransferase activity IPR013216; Putative methyltransferase KIAA1456 (EC 2.1.1.-) Kiaa1456 Mus musculus (Mouse) TR16511_c0_g1_i1 Q80UJ9 SETMR_MOUSE 4.00E-57 GO:0005694; GO:0018024; GO:0005634; GO:0008270 chromosome; histone-lysine N-methyltransferase activity; nucleus; zinc ion binding IPR003616; IPR007728; IPR001214; Histone-lysine N-methyltransferase SETMAR (EC 2.1.1.43) (SET domain and mariner transposase fusion gene-containing protein homolog) Setmar Mus musculus (Mouse) TR16511_c0_g1_i2 Q0VD24 SETMR_BOVIN 1.00E-57 GO:0005694; GO:0018024; GO:0005634; GO:0008270 chromosome; histone-lysine N-methyltransferase activity; nucleus; zinc ion binding IPR003616; IPR007728; IPR001214; Histone-lysine N-methyltransferase SETMAR (EC 2.1.1.43) (SET domain and mariner transposase fusion gene-containing protein homolog) SETMAR Bos taurus (Bovine) TR16513_c2_g1_i1 P23759 PAX7_HUMAN 2.00E-48 GO:0000983; GO:0009653; GO:0051216; GO:0006338; GO:0021904; GO:0048706; GO:0060415; GO:0043066; GO:0048663; GO:0005634; GO:0031062; GO:2000288; GO:0045944; GO:0010453; GO:0043393; GO:0014813; GO:0043565; GO:0003700; GO:0043403; GO:0021527 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; anatomical structure morphogenesis; cartilage development; chromatin remodeling; dorsal/ventral neural tube patterning; embryonic skeletal system development; muscle tissue morphogenesis; negative regulation of apoptotic process; neuron fate commitment; nucleus; positive regulation of histone methylation; positive regulation of myoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell fate commitment; regulation of protein binding; satellite cell commitment; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; skeletal muscle tissue regeneration; spinal cord association neuron differentiation IPR017970; IPR001356; IPR009057; IPR001523; IPR022106; IPR011991; Paired box protein Pax-7 (HuP1) PAX7 HUP1 Homo sapiens (Human) TR16520_c1_g1_i1 Q3U2V3 NUD18_MOUSE 1.00E-15 GO:0044717; GO:0044716; GO:0044715; GO:0046712; GO:0046057; GO:0046067; GO:0000287 8-hydroxy-dADP phosphatase activity; 8-oxo-GDP phosphatase activity; 8-oxo-dGDP phosphatase activity; GDP catabolic process; dADP catabolic process; dGDP catabolic process; magnesium ion binding IPR020476; IPR020084; IPR000086; IPR015797; "8-oxo-dGDP phosphatase NUDT18 (EC 3.6.1.58) (2-hydroxy-dADP phosphatase) (7,8-dihydro-8-oxoguanine phosphatase) (MutT homolog 3) (Nucleoside diphosphate-linked moiety X motif 18) (Nudix motif 18)" Nudt18 Mth3 Mus musculus (Mouse) TR16522_c1_g1_i1 O09000 NCOA3_MOUSE 2.00E-27 GO:0003682; GO:0005737; GO:0048589; GO:0016573; GO:0004402; GO:0060713; GO:0060744; GO:0035264; GO:0005654; GO:0006355; GO:0004871; GO:0003713; GO:0006351; GO:0060068 "chromatin binding; cytoplasm; developmental growth; histone acetylation; histone acetyltransferase activity; labyrinthine layer morphogenesis; mammary gland branching involved in thelarche; multicellular organism growth; nucleoplasm; regulation of transcription, DNA-dependent; signal transducer activity; transcription coactivator activity; transcription, DNA-dependent; vagina development" IPR011598; IPR010011; IPR009110; IPR014920; IPR017426; IPR000014; IPR013767; IPR014935; IPR008955; Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (Amplified in breast cancer-1 protein homolog) (AIB-1) (CBP-interacting protein) (p/CIP) (pCIP) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (ACTR) (TRAM-1) Ncoa3 Aib1 Pcip Rac3 Tram1 Mus musculus (Mouse) TR16523_c2_g1_i1 P51690 ARSE_HUMAN 2.00E-11 GO:0005795; GO:0004065; GO:0005788; GO:0006687; GO:0046872; GO:0043687; GO:0001501; GO:0044281 Golgi stack; arylsulfatase activity; endoplasmic reticulum lumen; glycosphingolipid metabolic process; metal ion binding; post-translational protein modification; skeletal system development; small molecule metabolic process IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase E (ASE) (EC 3.1.6.-) ARSE Homo sapiens (Human) TR16528_c0_g2_i1 Q9H1A4 APC1_HUMAN 9.00E-48 GO:0005680; GO:0031145; GO:0051301; GO:0005829; GO:0007067; GO:0007094; GO:0051436; GO:0005654; GO:0051437; GO:0070979 anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; cytosol; mitosis; mitotic spindle assembly checkpoint; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; protein K11-linked ubiquitination IPR024990; Protein modification; protein ubiquitination. Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) ANAPC1 TSG24 Homo sapiens (Human) TR16529_c0_g1_i1 Q9UNW1 MINP1_HUMAN 3.00E-20 GO:0003993; GO:0034417; GO:0030282; GO:0005788; GO:0052826; GO:0043647; GO:0008969; GO:0006797 acid phosphatase activity; bisphosphoglycerate 3-phosphatase activity; bone mineralization; endoplasmic reticulum lumen; inositol hexakisphosphate 2-phosphatase activity; inositol phosphate metabolic process; phosphohistidine phosphatase activity; polyphosphate metabolic process IPR000560; IPR016274; "Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80) (Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase) (Ins(1,3,4,5)P(4) 3-phosphatase)" MINPP1 MIPP UNQ900/PRO1917 Homo sapiens (Human) TR16531_c3_g1_i1 Q80WQ4 K1456_MOUSE 5.00E-09 GO:0008168 methyltransferase activity IPR013216; Putative methyltransferase KIAA1456 (EC 2.1.1.-) Kiaa1456 Mus musculus (Mouse) TR16533_c2_g1_i1 P21328 RTJK_DROME 2.00E-07 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) TR16542_c0_g1_i1 Q8N3P4 VPS8_HUMAN 1.00E-19 GO:0008270 zinc ion binding IPR011044; IPR025941; IPR015943; IPR001680; IPR017986; IPR001841; IPR013083; Vacuolar protein sorting-associated protein 8 homolog VPS8 KIAA0804 Homo sapiens (Human) TR16549_c0_g1_i2 Q6NZQ0 CP093_MOUSE 3.00E-52 Coiled-coil domain-containing protein C16orf93 homolog Gm166 Mus musculus (Mouse) TR1655_c0_g1_i1 Q5RCD7 SSRG_PONAB 1.00E-78 GO:0005784; GO:0006613; GO:0030176 Sec61 translocon complex; cotranslational protein targeting to membrane; integral to endoplasmic reticulum membrane IPR009779; Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma) SSR3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR16555_c0_g1_i1 B1H3C9 OST48_XENTR 4.00E-55 GO:0004579; GO:0016021; GO:0008250; GO:0018279; GO:0006486 dolichyl-diphosphooligosaccharide-protein glycotransferase activity; integral to membrane; oligosaccharyltransferase complex; protein N-linked glycosylation via asparagine; protein glycosylation IPR005013; Protein modification; protein glycosylation. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit) (EC 2.4.99.18) ddost Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR1656_c0_g1_i1 P08548 LIN1_NYCCO 2.00E-13 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR16560_c0_g1_i2 Q4W4Y0 CN028_HUMAN 9.00E-08 Uncharacterized protein C14orf28 (Dopamine receptor-interacting protein 1) C14orf28 DRIP1 Homo sapiens (Human) TR16569_c0_g1_i1 Q99KI0 ACON_MOUSE 2.00E-17 GO:0051538; GO:0051539; GO:0003994; GO:0006101; GO:0005506; GO:0006102; GO:0005739; GO:0005634; GO:0006099 "3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity; citrate metabolic process; iron ion binding; isocitrate metabolic process; mitochondrion; nucleus; tricarboxylic acid cycle" IPR015931; IPR015937; IPR001030; IPR015928; IPR015932; IPR018136; IPR006248; IPR000573; Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. "Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)" Aco2 Mus musculus (Mouse) TR16573_c0_g1_i1 Q3L254 WNT7B_CHICK 1.00E-80 GO:0016055; GO:0045165; GO:0005615; GO:0005109; GO:0070307; GO:0030182; GO:0046330; GO:0005578 Wnt receptor signaling pathway; cell fate commitment; extracellular space; frizzled binding; lens fiber cell development; neuron differentiation; positive regulation of JNK cascade; proteinaceous extracellular matrix IPR005817; IPR013300; IPR018161; Protein Wnt-7b WNT7B Gallus gallus (Chicken) TR16578_c0_g1_i1 Q5RF50 VKGC_PONAB 5.00E-64 GO:0005789; GO:0008488; GO:0016021; GO:0017187 endoplasmic reticulum membrane; gamma-glutamyl carboxylase activity; integral to membrane; peptidyl-glutamic acid carboxylation IPR011020; IPR014710; IPR011051; IPR007782; Vitamin K-dependent gamma-carboxylase (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase) GGCX Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR16622_c1_g1_i1 Q9GMT4 MDGA2_MACFA 3.00E-10 GO:0031225; GO:0005886 anchored to membrane; plasma membrane IPR008985; IPR003961; IPR007110; IPR013783; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 2 (MAM domain-containing protein 1) (Fragment) MDGA2 MAMDC1 QccE-16296 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR16622_c1_g2_i1 Q8NFP4 MDGA1_HUMAN 2.00E-11 GO:0046658; GO:0007420; GO:0001764; GO:0021527 anchored to plasma membrane; brain development; neuron migration; spinal cord association neuron differentiation IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3) MDGA1 MAMDC3 Homo sapiens (Human) TR16631_c0_g1_i1 Q9Y5Z4 HEBP2_HUMAN 3.00E-20 GO:0005737; GO:0005739 cytoplasm; mitochondrion IPR011256; IPR006917; Heme-binding protein 2 (Placental protein 23) (PP23) (Protein SOUL) HEBP2 C6orf34 SOUL Homo sapiens (Human) TR16632_c1_g1_i1 Q9NXK8 FXL12_HUMAN 4.00E-09 GO:0005737; GO:0016567; GO:0000151; GO:0006511 P49918; Q9H0A6 cytoplasm; protein ubiquitination; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process IPR001810; Protein modification; protein ubiquitination. F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12) FBXL12 FBL12 Homo sapiens (Human) TR16636_c1_g1_i1 P13395 SPTCA_DROME 2.00E-39 GO:0005794; GO:0003779; GO:0051693; GO:0016199; GO:0016323; GO:0005509; GO:0007417; GO:0045169; GO:0045478; GO:0030727; GO:0007294; GO:0005811; GO:0042062; GO:0048790; GO:0008017; GO:0007026; GO:0031594; GO:0007274; GO:0007308; GO:0030707; GO:0007009; GO:0008360; GO:0008091; GO:0045170; GO:0030721 Golgi apparatus; actin binding; actin filament capping; axon midline choice point recognition; basolateral plasma membrane; calcium ion binding; central nervous system development; fusome; fusome organization; germarium-derived female germ-line cyst formation; germarium-derived oocyte fate determination; lipid particle; long-term strengthening of neuromuscular junction; maintenance of presynaptic active zone structure; microtubule binding; negative regulation of microtubule depolymerization; neuromuscular junction; neuromuscular synaptic transmission; oocyte construction; ovarian follicle cell development; plasma membrane organization; regulation of cell shape; spectrin; spectrosome; spectrosome organization IPR011992; IPR014837; IPR018247; IPR002048; IPR001452; IPR018159; IPR013315; IPR002017; Spectrin alpha chain alpha-Spec SPEC-A CG1977 Drosophila melanogaster (Fruit fly) TR16649_c1_g1_i1 Q6WV16 GALT6_DROME 8.00E-25 GO:0000139; GO:0005795; GO:0005783; GO:0016021; GO:0009312; GO:0004653; GO:0006486 Golgi membrane; Golgi stack; endoplasmic reticulum; integral to membrane; oligosaccharide biosynthetic process; polypeptide N-acetylgalactosaminyltransferase activity; protein glycosylation IPR001173; IPR000772; Protein modification; protein glycosylation. N-acetylgalactosaminyltransferase 6 (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase 6) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6) (pp-GaNTase 6) pgant6 CG2103 Drosophila melanogaster (Fruit fly) TR16650_c0_g1_i2 O88384 VTI1B_MOUSE 1.00E-54 GO:0005794; GO:0016021; GO:0006886; GO:0031902; GO:0005765; GO:0048471; GO:0016192 Golgi apparatus; integral to membrane; intracellular protein transport; late endosome membrane; lysosomal membrane; perinuclear region of cytoplasm; vesicle-mediated transport IPR010989; IPR000727; IPR007705; Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1) Vti1b Vti1l1 Mus musculus (Mouse) TR16654_c2_g1_i1 Q86WI1 PKHL1_HUMAN 1.00E-28 GO:0005829; GO:0005615; GO:0006955; GO:0016021; GO:0004872 cytosol; extracellular space; immune response; integral to membrane; receptor activity IPR008972; IPR019316; IPR013783; IPR014756; IPR002909; IPR011658; IPR006626; IPR011050; Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) PKHD1L1 Homo sapiens (Human) TR16654_c6_g1_i1 P08F94 PKHD1_HUMAN 4.00E-15 GO:0031362; GO:0016324; GO:0016337; GO:0005813; GO:0042384; GO:0005737; GO:0042592; GO:0016021; GO:0001822; GO:0005932; GO:0072686; GO:0051271; GO:0072372; GO:0004872; GO:0010824 anchored to external side of plasma membrane; apical plasma membrane; cell-cell adhesion; centrosome; cilium assembly; cytoplasm; homeostatic process; integral to membrane; kidney development; microtubule basal body; mitotic spindle; negative regulation of cellular component movement; primary cilium; receptor activity; regulation of centrosome duplication IPR019316; IPR013783; IPR014756; IPR002909; IPR006626; IPR012334; IPR011050; Fibrocystin (Polycystic kidney and hepatic disease 1 protein) (Polyductin) (Tigmin) PKHD1 FCYT TIGM1 Homo sapiens (Human) TR16654_c8_g1_i1 Q80ZA4 PKHL1_MOUSE 8.00E-15 GO:0016021 integral to membrane IPR008972; IPR019316; IPR013783; IPR014756; IPR002909; IPR011658; IPR006626; IPR011050; Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86) Pkhd1l1 Mus musculus (Mouse) TR16657_c0_g1_i1 Q9CPY0 RRMJ2_MOUSE 1.00E-66 GO:0008168; GO:0005739; GO:0005730; GO:0031167 methyltransferase activity; mitochondrion; nucleolus; rRNA methylation IPR015507; IPR002877; Putative ribosomal RNA methyltransferase 2 (EC 2.1.1.-) (Protein ftsJ homolog 2) (rRNA (uridine-2'-O-)-methyltransferase) Ftsj2 Mus musculus (Mouse) TR16660_c0_g1_i2 Q6DIN3 MBTD1_XENTR 2.00E-38 GO:0016568; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR004092; IPR012313; MBT domain-containing protein 1 mbtd1 TTpA012c17.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR16670_c0_g1_i1 Q7ZUG0 RUXE_DANRE 1.00E-37 GO:0003723; GO:0000398; GO:0005681 "RNA binding; mRNA splicing, via spliceosome; spliceosomal complex" IPR010920; IPR001163; IPR006649; IPR027078; Small nuclear ribonucleoprotein E (snRNP-E) (Sm protein E) (Sm-E) (SmE) snrpe zgc:56682 Danio rerio (Zebrafish) (Brachydanio rerio) TR16672_c0_g1_i2 Q8TGM6 TAR1_YEAST 6.00E-07 GO:0005739; GO:0043457 mitochondrion; regulation of cellular respiration Protein TAR1 (Transcript antisense to ribosomal RNA protein 1) TAR1 ART1 YLR154W-C YLR154W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR16679_c0_g1_i1 Q8N4Q1 MIA40_HUMAN 5.00E-23 GO:0051084; GO:0005758; GO:0015035; GO:0045041; GO:0022417 'de novo' posttranslational protein folding; mitochondrial intermembrane space; protein disulfide oxidoreductase activity; protein import into mitochondrial intermembrane space; protein maturation by protein folding IPR010625; Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4) CHCHD4 MIA40 Homo sapiens (Human) TR16685_c2_g1_i1 O75592 MYCB2_HUMAN 2.00E-88 GO:0030424; GO:0021785; GO:0021952; GO:0015630; GO:0005634; GO:0051493; GO:0032880; GO:0006355; GO:0006351; GO:0004842; GO:0008270 Q99IB8 "axon; branchiomotor neuron axon guidance; central nervous system projection neuron axonogenesis; microtubule cytoskeleton; nucleus; regulation of cytoskeleton organization; regulation of protein localization; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR004939; IPR017868; IPR008979; IPR027047; IPR013783; IPR014756; IPR012983; IPR009091; IPR000408; IPR003646; IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc) MYCBP2 KIAA0916 PAM Homo sapiens (Human) TR16686_c0_g1_i1 Q5UPG5 YL093_MIMIV 4.00E-16 IPR002110; IPR020683; Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) TR16687_c0_g1_i1 P02402 RLA1_ARTSA 1.00E-27 GO:0005840; GO:0003735; GO:0006414 ribosome; structural constituent of ribosome; translational elongation IPR001813; IPR027534; IPR001859; 60S acidic ribosomal protein P1 (eL12'/ eL12'-P) Artemia salina (Brine shrimp) TR16689_c3_g1_i1 Q14678 KANK1_HUMAN 5.00E-13 GO:0008013; GO:0005737; GO:0035024; GO:0030837; GO:0030336; GO:0046627; GO:2000393; GO:0010977; GO:1900028; GO:1900025; GO:0005634; GO:0030177; GO:0035413; GO:0090303; GO:2000114; GO:0006355; GO:0032587; GO:0006351 Q9UQB8; Q9UQB8-4; P35222; Q7Z4S6; P62258; P61981; Q04917; P27348 "beta-catenin binding; cytoplasm; negative regulation of Rho protein signal transduction; negative regulation of actin filament polymerization; negative regulation of cell migration; negative regulation of insulin receptor signaling pathway; negative regulation of lamellipodium morphogenesis; negative regulation of neuron projection development; negative regulation of ruffle assembly; negative regulation of substrate adhesion-dependent cell spreading; nucleus; positive regulation of Wnt receptor signaling pathway; positive regulation of catenin import into nucleus; positive regulation of wound healing; regulation of establishment of cell polarity; regulation of transcription, DNA-dependent; ruffle membrane; transcription, DNA-dependent" IPR002110; IPR020683; IPR021939; KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) KANK1 ANKRD15 KANK KIAA0172 Homo sapiens (Human) TR16690_c0_g1_i1 Q9ET66 PI16_MOUSE 4.00E-12 GO:0005576; GO:0016021; GO:0030414 extracellular region; integral to membrane; peptidase inhibitor activity IPR001283; IPR018244; IPR014044; Peptidase inhibitor 16 (PI-16) (Cysteine-rich protease inhibitor) Pi16 Cripi Mus musculus (Mouse) TR16690_c2_g1_i1 P35782 VA52_VESCR 6.00E-09 GO:0005576 extracellular region IPR001283; IPR018244; IPR014044; IPR002413; Venom allergen 5.02 (Allergen Vesp c V.02) (Antigen 5-2) (Ag5-2) (Cysteine-rich venom protein) (CRVP) (allergen Vesp c 5.02) Vespa crabro (European hornet) TR16698_c0_g1_i1 Q9ERI2 RB27A_MOUSE 2.00E-60 GO:0019003; GO:0005525; GO:0003924; GO:0005794; GO:0016324; GO:0007596; GO:0005829; GO:0043316; GO:0030425; GO:0070382; GO:0005764; GO:0030318; GO:0042470; GO:0032402; GO:0032585; GO:0071985; GO:0043320; GO:0001750; GO:0045921; GO:0006605; GO:0030141; GO:0030667; GO:0007264 P47708; Q8TDW5 GDP binding; GTP binding; GTPase activity; Golgi apparatus; apical plasma membrane; blood coagulation; cytosol; cytotoxic T cell degranulation; dendrite; exocytic vesicle; lysosome; melanocyte differentiation; melanosome; melanosome transport; multivesicular body membrane; multivesicular body sorting pathway; natural killer cell degranulation; photoreceptor outer segment; positive regulation of exocytosis; protein targeting; secretory granule; secretory granule membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-27A Rab27a Mus musculus (Mouse) TR1671_c0_g1_i1 Q1JP75 DCXR_BOVIN 5.00E-17 GO:0042732; GO:0050038; GO:0006739; GO:0005903; GO:0005881; GO:0006006; GO:0016020; GO:0005902; GO:0016655; GO:0051289; GO:0005997 "D-xylose metabolic process; L-xylulose reductase (NADP+) activity; NADP metabolic process; brush border; cytoplasmic microtubule; glucose metabolic process; membrane; microvillus; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; protein homotetramerization; xylulose metabolic process" IPR002198; IPR002347; IPR016040; IPR020904; L-xylulose reductase (XR) (EC 1.1.1.10) (Dicarbonyl/L-xylulose reductase) DCXR Bos taurus (Bovine) TR16710_c0_g1_i1 O70496 CLCN7_MOUSE 6.00E-59 GO:0005524; GO:0015297; GO:0031410; GO:0016021; GO:0005765; GO:0009268; GO:0005247 Q8BGT0 ATP binding; antiporter activity; cytoplasmic vesicle; integral to membrane; lysosomal membrane; response to pH; voltage-gated chloride channel activity IPR000644; IPR014743; IPR001807; IPR002249; H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) Clcn7 Clc7 Mus musculus (Mouse) TR16710_c1_g2_i1 P51798 CLCN7_HUMAN 8.00E-26 GO:0005524; GO:0015297; GO:0005254; GO:0031410; GO:0016021; GO:0005765; GO:0009268; GO:0005247 ATP binding; antiporter activity; chloride channel activity; cytoplasmic vesicle; integral to membrane; lysosomal membrane; response to pH; voltage-gated chloride channel activity IPR000644; IPR014743; IPR001807; IPR002249; H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) CLCN7 Homo sapiens (Human) TR16710_c5_g1_i1 P51797 CLCN6_HUMAN 2.00E-17 GO:0005524; GO:0015297; GO:0006884; GO:0010008; GO:0016021; GO:0005765; GO:0007165; GO:0005247 ATP binding; antiporter activity; cell volume homeostasis; endosome membrane; integral to membrane; lysosomal membrane; signal transduction; voltage-gated chloride channel activity IPR000644; IPR014743; IPR001807; IPR002248; Chloride transport protein 6 (Chloride channel protein 6) (ClC-6) CLCN6 KIAA0046 Homo sapiens (Human) TR16713_c2_g2_i1 P13596 NCAM1_RAT 7.00E-10 GO:0007568; GO:0016338; GO:0071241; GO:0008092; GO:0005104; GO:0030426; GO:0008201; GO:0016021; GO:0007611; GO:0033555; GO:0060548; GO:0043025; GO:0031100; GO:0014012; GO:0019902; GO:0005886; GO:0060045; GO:0051930; GO:0042220; GO:0014076; GO:0010288; GO:0021794 P16092; Q63237 aging; calcium-independent cell-cell adhesion; cellular response to inorganic substance; cytoskeletal protein binding; fibroblast growth factor receptor binding; growth cone; heparin binding; integral to membrane; learning or memory; multicellular organismal response to stress; negative regulation of cell death; neuronal cell body; organ regeneration; peripheral nervous system axon regeneration; phosphatase binding; plasma membrane; positive regulation of cardiac muscle cell proliferation; regulation of sensory perception of pain; response to cocaine; response to fluoxetine; response to lead ion; thalamus development IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR009138; Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56) Ncam1 Ncam Rattus norvegicus (Rat) TR16713_c3_g1_i1 Q6WRI0 IGS10_HUMAN 1.00E-08 GO:0030154; GO:0005576; GO:0007275; GO:0001503 cell differentiation; extracellular region; multicellular organismal development; ossification IPR000483; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR003591; IPR000372; Immunoglobulin superfamily member 10 (IgSF10) (Calvaria mechanical force protein 608) (CMF608) IGSF10 CMF608 Homo sapiens (Human) TR16714_c1_g1_i1 P54277 PMS1_HUMAN 1.00E-23 GO:0005524; GO:0016887; GO:0032389; GO:0032407; GO:0006298; GO:0030983; GO:0007131; GO:0003697 ATP binding; ATPase activity; MutLalpha complex; MutSalpha complex binding; mismatch repair; mismatched DNA binding; reciprocal meiotic recombination; single-stranded DNA binding IPR013507; IPR014762; IPR002099; IPR003594; IPR009071; IPR020568; IPR014721; PMS1 protein homolog 1 (DNA mismatch repair protein PMS1) PMS1 PMSL1 Homo sapiens (Human) TR16714_c2_g1_i1 Q8IMA8 PANG2_DROME 2.00E-06 GO:0003705; GO:0008013; GO:0060070; GO:0009880; GO:0007507; GO:0007476; GO:0007500; GO:0005875; GO:0030178; GO:0045892; GO:0005634; GO:0045944; GO:0045610; GO:0072091; GO:0007435; GO:0007367; GO:0043565; GO:0035277; GO:0005667; GO:0044212 "RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; beta-catenin binding; canonical Wnt receptor signaling pathway; embryonic pattern specification; heart development; imaginal disc-derived wing morphogenesis; mesodermal cell fate determination; microtubule associated complex; negative regulation of Wnt receptor signaling pathway; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of hemocyte differentiation; regulation of stem cell proliferation; salivary gland morphogenesis; segment polarity determination; sequence-specific DNA binding; spiracle morphogenesis, open tracheal system; transcription factor complex; transcription regulatory region DNA binding" IPR009071; IPR024940; "Protein pangolin, isoform J (dTCF)" pan TCF CG34403 Drosophila melanogaster (Fruit fly) TR16716_c0_g1_i1 Q8BGC3 MOT12_MOUSE 7.00E-23 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) Slc16a12 Mct12 Mus musculus (Mouse) TR16722_c0_g1_i1 Q5XHA1 MED27_XENTR 2.00E-75 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR021627; Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) med27 crsp8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR16728_c0_g1_i1 Q76CA2 ACTP2_CYMEC 8.00E-18 GO:0019835; GO:0044179; GO:0016021; GO:0006811; GO:0044218 cytolysis; hemolysis in other organism; integral to membrane; ion transport; other organism cell membrane IPR015926; Echotoxin-2 (Echt 2) Cymatium echo (Giant triton) (Monoplex echo) TR16732_c0_g1_i1 F4KD71 DUR3_ARATH 2.00E-13 GO:0016021; GO:0005886; GO:0015293; GO:0015204 integral to membrane; plasma membrane; symporter activity; urea transmembrane transporter activity IPR001734; IPR019900; Urea-proton symporter DUR3 (AtDUR3) (High-affinity urea active transporter DUR3) DUR3 At5g45380 MFC19.5 Arabidopsis thaliana (Mouse-ear cress) TR16736_c1_g1_i1 Q8NEZ4 MLL3_HUMAN 3.00E-28 GO:0003677; GO:0042800; GO:0035097; GO:0035556; GO:0006355; GO:0006351; GO:0008270 Q14686 "DNA binding; histone methyltransferase activity (H3-K4 specific); histone methyltransferase complex; intracellular signal transduction; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR017956; IPR003889; IPR003888; IPR009071; IPR000637; IPR003616; IPR002219; IPR001214; IPR001594; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.43) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) KMT2C HALR KIAA1506 MLL3 Homo sapiens (Human) TR16736_c4_g1_i1 Q8NEZ4 MLL3_HUMAN 1.00E-26 GO:0003677; GO:0042800; GO:0035097; GO:0035556; GO:0006355; GO:0006351; GO:0008270 Q14686 "DNA binding; histone methyltransferase activity (H3-K4 specific); histone methyltransferase complex; intracellular signal transduction; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR017956; IPR003889; IPR003888; IPR009071; IPR000637; IPR003616; IPR002219; IPR001214; IPR001594; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.43) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) KMT2C HALR KIAA1506 MLL3 Homo sapiens (Human) TR16737_c0_g1_i1 P35478 CYTX_BOVIN 2.00E-08 GO:0004869; GO:0005737; GO:0010951 cysteine-type endopeptidase inhibitor activity; cytoplasm; negative regulation of endopeptidase activity IPR000010; IPR018073; IPR001713; Stefin-C Bos taurus (Bovine) TR16737_c0_g1_i2 P01040 CYTA_HUMAN 2.00E-07 GO:0016337; GO:0001533; GO:0004869; GO:0005737; GO:0030216; GO:0005634; GO:0018149; GO:0030674; GO:0005198 "cell-cell adhesion; cornified envelope; cysteine-type endopeptidase inhibitor activity; cytoplasm; keratinocyte differentiation; nucleus; peptide cross-linking; protein binding, bridging; structural molecule activity" IPR000010; IPR018073; IPR001713; "Cystatin-A (Cystatin-AS) (Stefin-A) [Cleaved into: Cystatin-A, N-terminally processed]" CSTA STF1 STFA Homo sapiens (Human) TR16743_c0_g1_i1 Q8NFA0 UBP32_HUMAN 2.00E-64 GO:0005794; GO:0005509; GO:0008234; GO:0016020; GO:0016579; GO:0004221; GO:0006511 Golgi apparatus; calcium ion binding; cysteine-type peptidase activity; membrane; protein deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR011992; IPR018247; IPR002048; IPR006615; IPR018200; IPR001394; IPR001125; IPR028135; Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) USP32 USP10 Homo sapiens (Human) TR16757_c2_g1_i1 Q16760 DGKD_HUMAN 6.00E-26 GO:0005524; GO:0003951; GO:0016049; GO:0005737; GO:0016023; GO:0019992; GO:0004143; GO:0046339; GO:0006897; GO:0007173; GO:0046872; GO:0007275; GO:0005543; GO:0005886; GO:0030168; GO:0046982; GO:0042803; GO:0051260; GO:0007205; GO:0015031; GO:0010033; GO:0019932 O75923 ATP binding; NAD+ kinase activity; cell growth; cytoplasm; cytoplasmic membrane-bounded vesicle; diacylglycerol binding; diacylglycerol kinase activity; diacylglycerol metabolic process; endocytosis; epidermal growth factor receptor signaling pathway; metal ion binding; multicellular organismal development; phospholipid binding; plasma membrane; platelet activation; protein heterodimerization activity; protein homodimerization activity; protein homooligomerization; protein kinase C-activating G-protein coupled receptor signaling pathway; protein transport; response to organic substance; second-messenger-mediated signaling IPR016064; IPR000756; IPR001206; IPR011993; IPR001849; IPR002219; IPR001660; IPR013761; IPR011510; Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta) DGKD KIAA0145 Homo sapiens (Human) TR16757_c3_g1_i1 Q52KW0 SHAN2_XENLA 4.00E-12 GO:0030054; GO:0005737; GO:0014069; GO:0045211 cell junction; cytoplasm; postsynaptic density; postsynaptic membrane IPR001478; IPR001660; IPR013761; IPR021129; SH3 and multiple ankyrin repeat domains protein 2 (Shank2) shank2 Xenopus laevis (African clawed frog) TR16759_c0_g1_i1 Q7XM31 RDR2_ORYSJ 2.00E-09 GO:0003723; GO:0003968; GO:0031047 RNA binding; RNA-directed RNA polymerase activity; gene silencing by RNA IPR007855; Probable RNA-dependent RNA polymerase 2 (OsRDR2) (EC 2.7.7.48) RDR2 Os04g0465700 LOC_Os04g39160 OSJNBb0048E02.13 Oryza sativa subsp. japonica (Rice) TR16762_c0_g1_i1 P28797 GRN_CAVPO 6.00E-36 GO:0005615 extracellular space IPR000118; Granulins (Proepithelin) (PEPI) [Cleaved into: Acrogranin (Progranulin); Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7] (Fragment) GRN Cavia porcellus (Guinea pig) TR16769_c0_g1_i2 Q6BEA0 PLXA4_DANRE 3.00E-09 GO:0007411; GO:0007414; GO:0016021; GO:0005622; GO:0001763; GO:0005886; GO:0004872; GO:0007165 axon guidance; axonal defasciculation; integral to membrane; intracellular; morphogenesis of a branching structure; plasma membrane; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A4 plxna4 Danio rerio (Zebrafish) (Brachydanio rerio) TR16771_c0_g1_i1 E6ZHJ8 FXL15_DICLA 4.00E-08 GO:0000086; GO:0019005; GO:0031146; GO:0030282; GO:0005737; GO:0009953; GO:0030513; GO:0016567 G2/M transition of mitotic cell cycle; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; bone mineralization; cytoplasm; dorsal/ventral pattern formation; positive regulation of BMP signaling pathway; protein ubiquitination IPR001810; Protein modification; protein ubiquitination. F-box/LRR-repeat protein 15 fbxl15 DLA_Ib03740 DLA_Ib03750 Dicentrarchus labrax (European seabass) (Morone labrax) TR16777_c2_g1_i1 Q9VKA4 Y1760_DROME 4.00E-26 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR017978; Probable G-protein coupled receptor CG31760 CG31760 Drosophila melanogaster (Fruit fly) TR16778_c0_g1_i1 Q9FT51 AB27G_ARATH 1.00E-24 GO:0005524; GO:0006200; GO:0016887; GO:0016021; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; integral to membrane; transport IPR003593; IPR013525; IPR003439; IPR017871; IPR027417; ABC transporter G family member 27 (ABC transporter ABCG.27) (AtABCG27) (Probable white-brown complex homolog protein 28) (AtWBC28) ABCG27 WBC28 At3g52310 T25B15.80 Arabidopsis thaliana (Mouse-ear cress) TR1679_c0_g1_i1 O79407 COX3_SCYCA 2.00E-105 GO:0019646; GO:0004129; GO:0016021; GO:0005743; GO:0045277 aerobic electron transport chain; cytochrome-c oxidase activity; integral to membrane; mitochondrial inner membrane; respiratory chain complex IV IPR024791; IPR000298; IPR013833; Cytochrome c oxidase subunit 3 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide III) MT-CO3 COIII COXIII MTCO3 Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula) TR16790_c0_g2_i1 Q91XQ5 CHSTF_MOUSE 2.00E-53 GO:0050656; GO:0000139; GO:0050659; GO:0019319; GO:0016021 3'-phosphoadenosine 5'-phosphosulfate binding; Golgi membrane; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity; hexose biosynthetic process; integral to membrane IPR027417; IPR000863; Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (B-cell RAG-associated gene protein) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST) Chst15 Brag Galnac4s6st Kiaa0598 Mus musculus (Mouse) TR16795_c0_g1_i2 Q6ZR08 DYH12_HUMAN 9.00E-35 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 12, axonemal (Axonemal beta dynein heavy chain 12) (Axonemal dynein heavy chain 12-like protein) (Axonemal dynein heavy chain 7-like protein) (Ciliary dynein heavy chain 12) (Dynein heavy chain 7-like, axonemal) (Dynein heavy chain domain-containing protein 2)" DNAH12 DHC3 DLP12 DNAH12L DNAH7L DNAHC3 DNHD2 HDHC3 HL19 Homo sapiens (Human) TR16795_c1_g1_i1 Q9C0G6 DYH6_HUMAN 9.00E-40 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 6, axonemal (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6)" DNAH6 DNAHC6 DNHL1 HL2 KIAA1697 Homo sapiens (Human) TR16804_c0_g1_i1 Q9VY28 RT25_DROME 5.00E-48 GO:0005763; GO:0003735; GO:0006412 mitochondrial small ribosomal subunit; structural constituent of ribosome; translation IPR007741; IPR012336; "Probable 28S ribosomal protein S25, mitochondrial (MRP-S25) (S25mt)" mRpS25 CG14413 Drosophila melanogaster (Fruit fly) TR16807_c0_g1_i1 Q09470 KCNA1_HUMAN 1.00E-37 GO:0016324; GO:0005251; GO:0030425; GO:0044224; GO:0043025; GO:0051260; GO:0007268; GO:0008076 Q62936; P78352 apical plasma membrane; delayed rectifier potassium channel activity; dendrite; juxtaparanode region of axon; neuronal cell body; protein homooligomerization; synaptic transmission; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003972; IPR004048; IPR003131; IPR028325; Potassium voltage-gated channel subfamily A member 1 (Voltage-gated K(+) channel HuKI) (Voltage-gated potassium channel HBK1) (Voltage-gated potassium channel subunit Kv1.1) KCNA1 Homo sapiens (Human) TR16807_c1_g1_i1 Q09081 KCNA2_RABIT 4.00E-26 GO:0051260; GO:0005249; GO:0008076 protein homooligomerization; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003972; IPR003131; IPR028325; Potassium voltage-gated channel subfamily A member 2 (KC22) (Voltage-gated potassium channel subunit Kv1.2) (Fragment) KCNA2 Oryctolagus cuniculus (Rabbit) TR16807_c2_g1_i1 P17970 KCNAB_DROME 1.00E-24 GO:0005251; GO:0008345; GO:0048812; GO:0051260; GO:0001508; GO:0008016; GO:0060025; GO:0008076 delayed rectifier potassium channel activity; larval locomotory behavior; neuron projection morphogenesis; protein homooligomerization; regulation of action potential; regulation of heart contraction; regulation of synaptic activity; voltage-gated potassium channel complex IPR000210; IPR011333; IPR005821; IPR003091; IPR003968; IPR003971; IPR003131; IPR028325; Potassium voltage-gated channel protein Shab Shab CG43128 Drosophila melanogaster (Fruit fly) TR16808_c1_g1_i1 Q1PSW8 LIN41_MOUSE 2.00E-06 GO:0000082; GO:0000932; GO:0008543; GO:0035198; GO:0010586; GO:0035278; GO:0001843; GO:2000637; GO:0051865; GO:2000177; GO:0072089; GO:0004842; GO:0008270 G1/S transition of mitotic cell cycle; cytoplasmic mRNA processing body; fibroblast growth factor receptor signaling pathway; miRNA binding; miRNA metabolic process; negative regulation of translation involved in gene silencing by miRNA; neural tube closure; positive regulation of gene silencing by miRNA; protein autoubiquitination; regulation of neural precursor cell proliferation; stem cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (mLin41) (Tripartite motif-containing protein 71) Trim71 Gm1127 Lin41 Mus musculus (Mouse) TR16809_c0_g1_i1 P04646 RL35A_RAT 6.00E-53 GO:0005840; GO:0003735; GO:0000049; GO:0006412 ribosome; structural constituent of ribosome; tRNA binding; translation IPR001780; IPR018266; IPR009000; 60S ribosomal protein L35a Rpl35a Rattus norvegicus (Rat) TR1681_c0_g1_i1 Q3T0M7 RANG_BOVIN 2.00E-21 GO:0005096; GO:0046907; GO:0043547 GTPase activator activity; intracellular transport; positive regulation of GTPase activity IPR011993; IPR000156; Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) RANBP1 Bos taurus (Bovine) TR16811_c1_g1_i1 Q9TXJ8 RECQ1_CAEEL 5.00E-15 GO:0005524; GO:0008026; GO:0006310; GO:0003676; GO:0005634 ATP binding; ATP-dependent helicase activity; DNA recombination; nucleic acid binding; nucleus IPR011545; IPR004589; IPR014001; IPR001650; IPR027417; IPR011991; Putative ATP-dependent DNA helicase Q1 (EC 3.6.4.12) K02F3.12 Caenorhabditis elegans TR16812_c0_g1_i1 A1ZAU8 SSP4_DROME 4.00E-19 GO:0005813; GO:0005737; GO:0005874; GO:0051011; GO:0051013; GO:0030496; GO:0000022; GO:0007026; GO:0005819 centrosome; cytoplasm; microtubule; microtubule minus-end binding; microtubule severing; midbody; mitotic spindle elongation; negative regulation of microtubule depolymerization; spindle IPR022613; IPR001715; IPR014797; IPR011033; Short spindle protein 4 ssp4 l(2)k07433 CG33130 Drosophila melanogaster (Fruit fly) TR16820_c0_g1_i1 P34040 RL32_TRIHA 7.00E-15 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001515; IPR018263; 60S ribosomal protein L32 rpl32 Trichoderma harzianum (Hypocrea lixii) TR16820_c0_g2_i1 P84323 RL32_DROPS 1.00E-54 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001515; IPR018263; 60S ribosomal protein L32 (Ribosomal protein 49) RpL32 M(3)99D rp49 GA20704 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR16822_c1_g1_i1 Q91WJ7 SPS2L_MOUSE 4.00E-13 GO:0005737; GO:0005730 cytoplasm; nucleolus IPR009816; IPR009060; SPATS2-like protein Spats2l Mus musculus (Mouse) TR16822_c2_g1_i1 Q8K1N4 SPAS2_MOUSE 5.00E-13 GO:0005737 cytoplasm IPR009816; IPR009060; Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) Spats2 Scr59 Mus musculus (Mouse) TR16827_c1_g1_i2 Q66JA9 U19BA_XENLA 6.00E-59 GO:0030030; GO:0035869; GO:0008289; GO:0042953 cell projection organization; ciliary transition zone; lipid binding; lipoprotein transport IPR008015; IPR014756; Protein unc-119 homolog B-A unc119b-a Xenopus laevis (African clawed frog) TR16828_c1_g1_i1 Q9UPV0 CE164_HUMAN 2.00E-17 GO:0006281; GO:0000086; GO:0051301; GO:0005814; GO:0005929; GO:0042384; GO:0005829; GO:0007067; GO:0005634 Q53HC0; Q92997; Q7Z494; Q6IQ55 DNA repair; G2/M transition of mitotic cell cycle; cell division; centriole; cilium; cilium assembly; cytosol; mitosis; nucleus IPR001202; Centrosomal protein of 164 kDa (Cep164) CEP164 KIAA1052 NPHP15 Homo sapiens (Human) TR16830_c0_g1_i1 Q03173 ENAH_MOUSE 5.00E-13 GO:0017124; GO:0008154; GO:0007411; GO:0005829; GO:0030175; GO:0005925; GO:0046907; GO:0030027; GO:0001843; GO:0005522; GO:0001725; GO:0045202 Q9UQB8 SH3 domain binding; actin polymerization or depolymerization; axon guidance; cytosol; filopodium; focal adhesion; intracellular transport; lamellipodium; neural tube closure; profilin binding; stress fiber; synapse IPR011993; IPR000156; IPR014885; IPR000697; Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1) Enah Mena Ndpp1 Mus musculus (Mouse) TR16835_c1_g1_i1 P10040 CRB_DROME 1.00E-11 GO:0016324; GO:0016327; GO:0005509; GO:0061336; GO:0046664; GO:0045198; GO:0016332; GO:0016334; GO:0016021; GO:0035002; GO:0035090; GO:0061024; GO:0045746; GO:0046621; GO:0048477; GO:0045494; GO:0008284; GO:0042327; GO:0008104; GO:0035330; GO:0045570; GO:0016028; GO:0042052; GO:0007435; GO:0005918; GO:0030507; GO:0035003; GO:0045186; GO:0045218 Q0E974 "apical plasma membrane; apicolateral plasma membrane; calcium ion binding; cell morphogenesis involved in Malpighian tubule morphogenesis; dorsal closure, amnioserosa morphology change; establishment of epithelial cell apical/basal polarity; establishment or maintenance of polarity of embryonic epithelium; establishment or maintenance of polarity of follicular epithelium; integral to membrane; liquid clearance, open tracheal system; maintenance of apical/basal cell polarity; membrane organization; negative regulation of Notch signaling pathway; negative regulation of organ growth; oogenesis; photoreceptor cell maintenance; positive regulation of cell proliferation; positive regulation of phosphorylation; protein localization; regulation of hippo signaling cascade; regulation of imaginal disc growth; rhabdomere; rhabdomere development; salivary gland morphogenesis; septate junction; spectrin binding; subapical complex; zonula adherens assembly; zonula adherens maintenance" IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protein crumbs (95F) crb CG6383 Drosophila melanogaster (Fruit fly) TR16835_c1_g2_i1 Q90953 CSPG2_CHICK 5.00E-15 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Gallus gallus (Chicken) TR16835_c2_g1_i1 Q9UM47 NOTC3_HUMAN 8.00E-11 GO:0000139; GO:0007220; GO:0007219; GO:0005509; GO:0005829; GO:0005789; GO:0005576; GO:0030900; GO:0072104; GO:0016021; GO:0045665; GO:0048663; GO:0005654; GO:0005886; GO:0048661; GO:0006355; GO:0006367 Q9R1P4 "Golgi membrane; Notch receptor processing; Notch signaling pathway; calcium ion binding; cytosol; endoplasmic reticulum membrane; extracellular region; forebrain development; glomerular capillary formation; integral to membrane; negative regulation of neuron differentiation; neuron fate commitment; nucleoplasm; plasma membrane; positive regulation of smooth muscle cell proliferation; regulation of transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022331; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] NOTCH3 Homo sapiens (Human) TR1684_c0_g1_i1 Q9EQG6 KDIS_RAT 2.00E-06 GO:0030165; GO:0016482; GO:0005829; GO:0016021; GO:0005770; GO:0038180; GO:0010976; GO:0043234; GO:0019901; GO:0019887 P46109 PDZ domain binding; cytoplasmic transport; cytosol; integral to membrane; late endosome; nerve growth factor signaling pathway; positive regulation of neuron projection development; protein complex; protein kinase binding; protein kinase regulator activity IPR002110; IPR020683; IPR011646; IPR013761; Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) Kidins220 Arms Rattus norvegicus (Rat) TR16841_c0_g1_i1 O43301 HS12A_HUMAN 6.00E-10 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR16842_c0_g1_i1 Q864Z3 S22A6_BOVIN 3.00E-53 GO:0015742; GO:0016323; GO:0005452; GO:0005887; GO:0008514; GO:0097254 alpha-ketoglutarate transport; basolateral plasma membrane; inorganic anion exchanger activity; integral to plasma membrane; organic anion transmembrane transporter activity; renal tubular secretion IPR020846; IPR016196; IPR004749; IPR005828; Solute carrier family 22 member 6 (Organic anion transporter 1) (Renal organic anion transporter 1) (ROAT1) SLC22A6 OAT1 Bos taurus (Bovine) TR16842_c0_g1_i2 Q95R48 OCTL_DROME 8.00E-63 GO:0007390; GO:0016021; GO:0015101; GO:0030307; GO:0040018 germ-band shortening; integral to membrane; organic cation transmembrane transporter activity; positive regulation of cell growth; positive regulation of multicellular organism growth IPR020846; IPR016196; IPR005828; Organic cation transporter-like protein Orct2 CG13610 Drosophila melanogaster (Fruit fly) TR16851_c0_g1_i1 Q9ZR37 DUS1_ARATH 3.00E-15 GO:0005737; GO:0005634; GO:0035335; GO:0004725; GO:0008138 cytoplasm; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR020417; IPR000340; IPR020422; IPR024950; IPR000387; Dual specificity protein phosphatase 1 (AtDsPTP1) (EC 3.1.3.16) (EC 3.1.3.48) DSPTP1 At3g23610 MDB19.10 Arabidopsis thaliana (Mouse-ear cress) TR16865_c0_g1_i1 Q04666 HES1_RAT 1.00E-16 GO:0071820; GO:0001078; GO:0007262; GO:0021861; GO:2000978; GO:0060253; GO:0048715; GO:2000974; GO:0097150; GO:0005654; GO:0043388; GO:0048711; GO:0042517; GO:0006461; GO:0042803; GO:0043565 N-box binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; STAT protein import into nucleus; forebrain radial glial cell differentiation; negative regulation of forebrain neuron differentiation; negative regulation of glial cell proliferation; negative regulation of oligodendrocyte differentiation; negative regulation of pro-B cell differentiation; neuronal stem cell maintenance; nucleoplasm; positive regulation of DNA binding; positive regulation of astrocyte differentiation; positive regulation of tyrosine phosphorylation of Stat3 protein; protein complex assembly; protein homodimerization activity; sequence-specific DNA binding IPR011598; IPR003650; IPR018352; Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy-like protein) (RHL) Hes1 Hes-1 Hl Rattus norvegicus (Rat) TR16868_c1_g1_i1 Q09630 GRM1_CAEEL 5.00E-06 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR000162; IPR028082; Probable metabotropic glutamate receptor mgl-1 mgl-1 ZC506.4 Caenorhabditis elegans TR16869_c0_g1_i1 Q5ZKJ5 TM180_CHICK 3.00E-06 GO:0016021 integral to membrane IPR016196; Transmembrane protein 180 TMEM180 RCJMB04_10g6 Gallus gallus (Chicken) TR16880_c0_g2_i1 Q90WV8 IBP5_XENLA 3.00E-07 GO:0009952; GO:0005576; GO:0005520; GO:0048009; GO:0007399; GO:0001558 anterior/posterior pattern specification; extracellular region; insulin-like growth factor binding; insulin-like growth factor receptor signaling pathway; nervous system development; regulation of cell growth IPR009030; IPR012213; IPR000867; IPR009168; IPR022321; IPR017891; IPR000716; Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5) (xIGFBP-5) igfbp5 Xenopus laevis (African clawed frog) TR16882_c0_g1_i1 P26221 GUN4_THEFU 6.00E-42 GO:0008810; GO:0030248; GO:0030245 cellulase activity; cellulose binding; cellulose catabolic process IPR008928; IPR012341; IPR008965; IPR001956; IPR012291; IPR018366; IPR001919; IPR003961; IPR001701; IPR018221; IPR013783; Glycan metabolism; cellulose degradation. "Endoglucanase E-4 (EC 3.2.1.4) (Cellulase E-4) (Cellulase E4) (Endo-1,4-beta-glucanase E-4)" celD Thermobifida fusca (Thermomonospora fusca) TR16884_c1_g1_i1 Q8BKX6 SMG1_MOUSE 6.00E-27 GO:0005524; GO:0006281; GO:0005737; GO:0046872; GO:0000184; GO:0005634; GO:0018105; GO:0046854; GO:0046777; GO:0004674 "ATP binding; DNA repair; cytoplasm; metal ion binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus; peptidyl-serine phosphorylation; phosphatidylinositol phosphorylation; protein autophosphorylation; protein serine/threonine kinase activity" IPR016024; IPR003152; IPR011009; IPR000403; IPR018936; IPR014009; Serine/threonine-protein kinase SMG1 (SMG-1) (EC 2.7.11.1) Smg1 Kiaa0421 Mus musculus (Mouse) TR16889_c0_g1_i1 P43679 ACHB3_CHICK 2.00E-29 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit beta-3 CHRNB3 Gallus gallus (Chicken) TR16889_c1_g1_i1 P48180 ACH1_CAEEL 4.00E-30 GO:0004889; GO:0030054; GO:0042995; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; cell projection; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha-type acr-16 acr-16 Ce21 F25G6.3 Caenorhabditis elegans TR16890_c0_g1_i1 Q9VGH7 CLCN2_DROME 2.00E-56 GO:0015629; GO:0030554; GO:0034707; GO:0006821; GO:0005247 actin cytoskeleton; adenyl nucleotide binding; chloride channel complex; chloride transport; voltage-gated chloride channel activity IPR000644; IPR014743; IPR001807; Chloride channel protein 2 (ClC-2) (DmClC-2) (Chloride channel-a) ClC-a CG31116 Drosophila melanogaster (Fruit fly) TR16890_c0_g2_i1 P92941 CLCA_ARATH 5.00E-12 GO:0030554; GO:0034707; GO:0006821; GO:0005622; GO:0015112; GO:0010167; GO:0005247 adenyl nucleotide binding; chloride channel complex; chloride transport; intracellular; nitrate transmembrane transporter activity; response to nitrate; voltage-gated chloride channel activity IPR000644; IPR014743; IPR001807; IPR002251; Chloride channel protein CLC-a (AtCLC-a) (CBS domain-containing protein CBSCLC5) CLC-A CBSCLC5 At5g40890 MHK7.12 Arabidopsis thaliana (Mouse-ear cress) TR16893_c0_g1_i2 Q5ZIJ9 MIB2_CHICK 5.00E-17 GO:0007219; GO:0005737; GO:0004842; GO:0008270 Notch signaling pathway; cytoplasm; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) TR16895_c1_g1_i1 P55968 PO4F1_CHICK 1.00E-47 GO:0007275; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001356; IPR009057; IPR010982; IPR013847; IPR000327; "POU domain, class 4, transcription factor 1 (Brain-specific homeobox/POU domain protein 3A) (Brain-3A) (Brn-3A) (Fragment)" POU4F1 BRN-3A BRN3A Gallus gallus (Chicken) TR16902_c0_g1_i1 Q4V7B1 CC067_RAT 3.00E-11 IPR007714; Uncharacterized protein C3orf67 homolog Rattus norvegicus (Rat) TR16903_c2_g1_i1 A1YF12 ZNF16_GORGO 6.00E-12 GO:0003677; GO:0007049; GO:0051301; GO:0072707; GO:0046872; GO:0043066; GO:0005634; GO:1901989; GO:0051781; GO:0008284; GO:0045648; GO:0033674; GO:0045654; GO:0006355; GO:0006351 "DNA binding; cell cycle; cell division; cellular response to sodium dodecyl sulfate; metal ion binding; negative regulation of apoptotic process; nucleus; positive regulation of cell cycle phase transition; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of kinase activity; positive regulation of megakaryocyte differentiation; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 16 ZNF16 Gorilla gorilla gorilla (Lowland gorilla) TR16911_c0_g1_i1 O35235 TNF11_MOUSE 9.00E-06 GO:0070371; GO:0007257; GO:0045453; GO:0055074; GO:0005737; GO:0005615; GO:0006955; GO:0016021; GO:0005622; GO:0048535; GO:0060749; GO:0033598; GO:0002548; GO:0009887; GO:0001503; GO:0030316; GO:0002158; GO:0005886; GO:0071848; GO:0043123; GO:0046330; GO:0051092; GO:0050870; GO:0045780; GO:0051466; GO:0071812; GO:0034112; GO:0045672; GO:0051897; GO:0051091; GO:0045944; GO:0051260; GO:0033209 ERK1 and ERK2 cascade; activation of JUN kinase activity; bone resorption; calcium ion homeostasis; cytoplasm; extracellular space; immune response; integral to membrane; intracellular; lymph node development; mammary gland alveolus development; mammary gland epithelial cell proliferation; monocyte chemotaxis; organ morphogenesis; ossification; osteoclast differentiation; osteoclast proliferation; plasma membrane; positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell activation; positive regulation of bone resorption; positive regulation of corticotropin-releasing hormone secretion; positive regulation of fever generation by positive regulation of prostaglandin secretion; positive regulation of homotypic cell-cell adhesion; positive regulation of osteoclast differentiation; positive regulation of protein kinase B signaling cascade; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein homooligomerization; tumor necrosis factor-mediated signaling pathway IPR006052; IPR017355; IPR008983; "Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]" Tnfsf11 Opgl Rankl Trance Mus musculus (Mouse) TR16919_c0_g1_i1 O08623 SQSTM_RAT 4.00E-08 GO:0042169; GO:0016235; GO:0006915; GO:0005776; GO:0030154; GO:0000932; GO:0031410; GO:0005783; GO:0005770; GO:0005764; GO:0016236; GO:0005634; GO:0001934; GO:0000407; GO:0051291; GO:0042803; GO:0005080; GO:0043122; GO:0043130; GO:0008270 SH2 domain binding; aggresome; apoptotic process; autophagic vacuole; cell differentiation; cytoplasmic mRNA processing body; cytoplasmic vesicle; endoplasmic reticulum; late endosome; lysosome; macroautophagy; nucleus; positive regulation of protein phosphorylation; pre-autophagosomal structure; protein heterooligomerization; protein homodimerization activity; protein kinase C binding; regulation of I-kappaB kinase/NF-kappaB cascade; ubiquitin binding; zinc ion binding IPR000270; IPR009060; IPR015940; IPR000433; Sequestosome-1 (Protein kinase C-zeta-interacting protein) (PKC-zeta-interacting protein) (Ubiquitin-binding protein p62) Sqstm1 Zip Rattus norvegicus (Rat) TR16921_c0_g1_i1 Q99ML0 ZMY10_MOUSE 3.00E-16 GO:0005737; GO:0046872 cytoplasm; metal ion binding IPR017333; IPR002893; Zinc finger MYND domain-containing protein 10 (Protein BLu) Zmynd10 Blu Mus musculus (Mouse) TR16921_c1_g1_i1 O75800 ZMY10_HUMAN 8.00E-18 GO:0005737; GO:0046872 Q9Y3Q8 cytoplasm; metal ion binding IPR017333; IPR002893; Zinc finger MYND domain-containing protein 10 (Protein BLu) ZMYND10 BLU LUCA12.4 Homo sapiens (Human) TR16923_c0_g1_i1 Q059U7 INTU_MOUSE 7.00E-32 GO:0009986; GO:0042384; GO:0005737; GO:0060173; GO:0008589; GO:0021513 cell surface; cilium assembly; cytoplasm; limb development; regulation of smoothened signaling pathway; spinal cord dorsal/ventral patterning IPR001478; Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6) Intu Kiaa1284 Pdzd6 Mus musculus (Mouse) TR16925_c1_g1_i1 Q8C8M1 FA60A_MOUSE 4.00E-22 GO:0016580; GO:0030336 Sin3 complex; negative regulation of cell migration IPR026065; Protein FAM60A (Tera protein) Fam60a Tera Mus musculus (Mouse) TR16929_c0_g1_i1 Q96MR6 WDR65_HUMAN 1.00E-48 IPR011047; IPR015943; IPR001680; IPR017986; WD repeat-containing protein 65 WDR65 Homo sapiens (Human) TR16929_c1_g1_i1 Q96MR6 WDR65_HUMAN 2.00E-38 IPR011047; IPR015943; IPR001680; IPR017986; WD repeat-containing protein 65 WDR65 Homo sapiens (Human) TR16931_c1_g1_i1 Q3ZBD0 PSD7_BOVIN 6.00E-158 GO:0000502 proteasome complex IPR000555; IPR024969; 26S proteasome non-ATPase regulatory subunit 7 (26S proteasome regulatory subunit RPN8) PSMD7 Bos taurus (Bovine) TR16931_c1_g2_i1 B4NJR8 EI3F1_DROWI 6.00E-14 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0006446; GO:0003743 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; regulation of translational initiation; translation initiation factor activity IPR027531; IPR000555; IPR024969; Eukaryotic translation initiation factor 3 subunit F-1 (eIF3f-1) (Eukaryotic translation initiation factor 3 subunit 5-1) eIF3-S5-1 GK14430 Drosophila willistoni (Fruit fly) TR16935_c2_g1_i1 Q9ERI6 RDH14_MOUSE 3.00E-07 GO:0005783; GO:0005739; GO:0016491 endoplasmic reticulum; mitochondrion; oxidoreductase activity IPR002198; IPR002347; IPR016040; Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2) Rdh14 Mus musculus (Mouse) TR16939_c0_g2_i1 B1JP69 TATD_YERPY 4.00E-13 GO:0005737; GO:0016888; GO:0046872; GO:0006515; GO:0090305 "cytoplasm; endodeoxyribonuclease activity, producing 5'-phosphomonoesters; metal ion binding; misfolded or incompletely synthesized protein catabolic process; nucleic acid phosphodiester bond hydrolysis" IPR018228; IPR024918; IPR001130; Tat-linked quality control protein TatD (Deoxyribonuclease TatD) (DNase TatD) (EC 3.1.21.-) tatD YPK_3939 Yersinia pseudotuberculosis serotype O:3 (strain YPIII) TR16942_c1_g1_i1 Q9JK72 CCS_RAT 1.00E-32 GO:0005829; GO:0019899; GO:0015680; GO:0005743; GO:0005634; GO:0019430; GO:0004784; GO:0016532; GO:0008270 cytosol; enzyme binding; intracellular copper ion transport; mitochondrial inner membrane; nucleus; removal of superoxide radicals; superoxide dismutase activity; superoxide dismutase copper chaperone activity; zinc ion binding IPR006121; IPR024134; IPR018152; IPR001424; Copper chaperone for superoxide dismutase (Superoxide dismutase copper chaperone) Ccs Rattus norvegicus (Rat) TR16942_c1_g2_i1 O73872 SODC_DANRE 7.00E-56 GO:0005507; GO:0005829; GO:0005739; GO:0070050; GO:0005634; GO:0019430; GO:0010038; GO:0051597; GO:0009410; GO:0004784; GO:0008270 copper ion binding; cytosol; mitochondrion; neuron cellular homeostasis; nucleus; removal of superoxide radicals; response to metal ion; response to methylmercury; response to xenobiotic stimulus; superoxide dismutase activity; zinc ion binding IPR024134; IPR018152; IPR001424; Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) sod1 cuzn Danio rerio (Zebrafish) (Brachydanio rerio) TR16945_c0_g1_i1 P62752 RL23A_RAT 3.00E-62 GO:0008283; GO:0022625; GO:0000166; GO:0005634; GO:0019843; GO:0003735; GO:0006412 cell proliferation; cytosolic large ribosomal subunit; nucleotide binding; nucleus; rRNA binding; structural constituent of ribosome; translation IPR012677; IPR019985; IPR012678; IPR001014; IPR005633; IPR013025; 60S ribosomal protein L23a Rpl23a Rattus norvegicus (Rat) TR16946_c0_g1_i1 Q92622 RUBIC_HUMAN 4.00E-19 GO:0006914; GO:0005769; GO:0006897; GO:0005770; GO:0005764; GO:0010507; GO:0045806 autophagy; early endosome; endocytosis; late endosome; lysosome; negative regulation of autophagy; negative regulation of endocytosis IPR025258; IPR004012; Run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) KIAA0226 Homo sapiens (Human) TR16954_c1_g1_i1 P0C6F1 DYH2_MOUSE 7.00E-41 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR026976; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 2, axonemal (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2)" Dnah2 Dnahc2 Mus musculus (Mouse) TR16965_c0_g2_i1 Q9XZC8 SEM2A_SCHGR 4.00E-15 GO:0030154; GO:0005576; GO:0016020; GO:0007399; GO:0004872 cell differentiation; extracellular region; membrane; nervous system development; receptor activity IPR007110; IPR013783; IPR003599; IPR016201; IPR001627; IPR027231; IPR015943; Semaphorin-2A (Sema-2A) (Sema II) SEMA-2A Schistocerca gregaria (Desert locust) TR16969_c1_g1_i1 P17437 XP2_XENLA 5.00E-16 GO:0005576 extracellular region IPR000519; IPR017994; IPR017957; Skin secretory protein xP2 (Protein APEG) p2 Xenopus laevis (African clawed frog) TR16969_c1_g1_i2 Q05049 MUC1_XENLA 6.00E-24 GO:0005576 extracellular region IPR000519; IPR017994; IPR017957; Integumentary mucin C.1 (FIM-C.1) (Fragment) Xenopus laevis (African clawed frog) TR1697_c0_g1_i1 Q69Z23 DYH17_MOUSE 2.00E-49 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 17, axonemal (Axonemal beta dynein heavy chain 17) (Ciliary dynein heavy chain 17)" Dnah17 Dnahc17 Kiaa3028 Mus musculus (Mouse) TR16970_c0_g1_i1 Q6V0L0 CP26C_HUMAN 5.00E-36 GO:0009952; GO:0007417; GO:0005789; GO:0020037; GO:0016021; GO:0005506; GO:0048387; GO:0014032; GO:0048284; GO:0008401; GO:0001972; GO:0034653; GO:0006805 anterior/posterior pattern specification; central nervous system development; endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding; negative regulation of retinoic acid receptor signaling pathway; neural crest cell development; organelle fusion; retinoic acid 4-hydroxylase activity; retinoic acid binding; retinoic acid catabolic process; xenobiotic metabolic process IPR001128; IPR017972; IPR002403; Cytochrome P450 26C1 (EC 1.14.-.-) CYP26C1 Homo sapiens (Human) TR16970_c0_g2_i1 O43174 CP26A_HUMAN 1.00E-38 GO:0009952; GO:0071300; GO:0007417; GO:0005789; GO:0020037; GO:0005506; GO:0048387; GO:0014032; GO:0019825; GO:0008401; GO:0001972; GO:0034653; GO:0048384; GO:0006805 anterior/posterior pattern specification; cellular response to retinoic acid; central nervous system development; endoplasmic reticulum membrane; heme binding; iron ion binding; negative regulation of retinoic acid receptor signaling pathway; neural crest cell development; oxygen binding; retinoic acid 4-hydroxylase activity; retinoic acid binding; retinoic acid catabolic process; retinoic acid receptor signaling pathway; xenobiotic metabolic process IPR001128; IPR017972; IPR002403; Cytochrome P450 26A1 (EC 1.14.-.-) (Cytochrome P450 retinoic acid-inactivating 1) (Cytochrome P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome) CYP26A1 CYP26 P450RAI1 Homo sapiens (Human) TR16977_c1_g1_i1 Q6MZM0 HPHL1_HUMAN 1.00E-54 GO:0005507; GO:0006825; GO:0004322; GO:0016021 copper ion binding; copper ion transport; ferroxidase activity; integral to membrane IPR011706; IPR011707; IPR002355; IPR008972; Hephaestin-like protein 1 (EC 1.-.-.-) HEPHL1 Homo sapiens (Human) TR1698_c0_g2_i1 O77302 RS10_LUMRU 1.00E-65 GO:0005840 ribosome IPR005326; 40S ribosomal protein S10 RPS10 Lumbricus rubellus (Humus earthworm) TR16982_c0_g1_i1 Q9NS56 TOPRS_HUMAN 9.00E-10 GO:0003677; GO:0016605; GO:0019789; GO:0003823; GO:0005814; GO:0036064; GO:0000930; GO:0008630; GO:0051457; GO:0030496; GO:0043066; GO:0016607; GO:0035845; GO:0032391; GO:0045893; GO:0051443; GO:0043161; GO:0070936; GO:0006513; GO:0016925; GO:0042127; GO:0010842; GO:0046549; GO:0046548; GO:0000922; GO:0006351; GO:0004842; GO:0008270 "DNA binding; PML body; SUMO ligase activity; antigen binding; centriole; cilium basal body; gamma-tubulin complex; intrinsic apoptotic signaling pathway in response to DNA damage; maintenance of protein location in nucleus; midbody; negative regulation of apoptotic process; nuclear speck; photoreceptor cell outer segment organization; photoreceptor connecting cilium; positive regulation of transcription, DNA-dependent; positive regulation of ubiquitin-protein ligase activity; proteasomal ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; protein monoubiquitination; protein sumoylation; regulation of cell proliferation; retina layer formation; retinal cone cell development; retinal rod cell development; spindle pole; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) TOPORS LUN TP53BPL Homo sapiens (Human) TR16983_c0_g1_i1 Q55GU0 Y9955_DICDI 4.00E-07 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR001245; IPR002290; IPR008271; Probable serine/threonine-protein kinase DDB_G0267514 (EC 2.7.11.1) DDB_G0267514 Dictyostelium discoideum (Slime mold) TR16991_c0_g1_i1 Q95V84 RL38_BRABE 4.00E-21 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR002675; 60S ribosomal protein L38 RPL38 Branchiostoma belcheri (Amphioxus) TR16992_c0_g1_i1 Q5RFH3 NDKB_PONAB 5.00E-79 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0071944; GO:0005737; GO:0007229; GO:0030027; GO:0046872; GO:0004550; GO:0018106; GO:0005886; GO:0045944; GO:0004673; GO:0001726 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; cell periphery; cytoplasm; integrin-mediated signaling pathway; lamellipodium; metal ion binding; nucleoside diphosphate kinase activity; peptidyl-histidine phosphorylation; plasma membrane; positive regulation of transcription from RNA polymerase II promoter; protein histidine kinase activity; ruffle IPR001564; IPR023005; Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (Histidine protein kinase NDKB) (EC 2.7.13.3) NME2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR16993_c2_g2_i1 Q06561 UNC52_CAEEL 7.00E-16 GO:0005604; GO:0016477; GO:0009792; GO:0007173; GO:0031581; GO:0048644; GO:0030239; GO:0040017; GO:0005198 basement membrane; cell migration; embryo development ending in birth or egg hatching; epidermal growth factor receptor signaling pathway; hemidesmosome assembly; muscle organ morphogenesis; myofibril assembly; positive regulation of locomotion; structural molecule activity IPR008985; IPR013320; IPR000742; IPR013032; IPR002049; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR018031; IPR000034; IPR001791; IPR023415; IPR002172; Basement membrane proteoglycan (Perlecan homolog) (Uncoordinated protein 52) (Protein unc-52) unc-52 ZC101.2 Caenorhabditis elegans TR16993_c3_g1_i1 B4F785 EGFLA_RAT 2.00E-13 GO:0030054; GO:0005578; GO:0045202 cell junction; proteinaceous extracellular matrix; synapse IPR008985; IPR013320; IPR000742; IPR013032; IPR003961; IPR013783; IPR001791; "Pikachurin (EGF-like, fibronectin type-III and laminin G-like domain-containing protein)" Egflam Rattus norvegicus (Rat) TR1700_c0_g1_i1 Q9W141 ATPK_DROME 6.00E-36 GO:0006754; GO:0046331; GO:0005811; GO:0031966; GO:0015992; GO:0045263 Q9VTU0 "ATP biosynthetic process; lateral inhibition; lipid particle; mitochondrial membrane; proton transport; proton-transporting ATP synthase complex, coupling factor F(o)" IPR019344; "Putative ATP synthase subunit f, mitochondrial" CG4692 Drosophila melanogaster (Fruit fly) TR17018_c2_g1_i1 Q6YKA8 DRK_DROSI 1.00E-85 GO:0005070; GO:0005886; GO:0004871 SH3/SH2 adaptor activity; plasma membrane; signal transducer activity IPR000108; IPR000980; IPR001452; Protein E(sev)2B (Downstream of receptor kinase) (Protein enhancer of sevenless 2B) (SH2-SH3 adapter protein drk) drk E(sev)2B Drosophila simulans (Fruit fly) TR17019_c2_g1_i1 Q9PTS8 ACHA9_CHICK 3.00E-10 GO:0004889; GO:0005262; GO:0030054; GO:0007204; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; calcium channel activity; cell junction; elevation of cytosolic calcium ion concentration; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9) CHRNA9 Gallus gallus (Chicken) TR17020_c0_g1_i1 Q5ZJP7 KCTD7_CHICK 4.00E-24 GO:0005829; GO:0005886; GO:0051260 cytosol; plasma membrane; protein homooligomerization IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein KCTD7 KCTD7 RCJMB04_16j10 Gallus gallus (Chicken) TR17021_c1_g1_i1 P38866 FMO1_YEAST 5.00E-09 GO:0004499; GO:0050661; GO:0005789; GO:0050660; GO:0006457 "N,N-dimethylaniline monooxygenase activity; NADP binding; endoplasmic reticulum membrane; flavin adenine dinucleotide binding; protein folding" IPR000960; IPR020946; Thiol-specific monooxygenase (EC 1.14.13.-) (Flavin-dependent monooxygenase) FMO1 YHR176W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR17022_c0_g1_i1 P08181 CSK2A_DROME 9.00E-06 GO:0005524; GO:0016055; GO:0007411; GO:0022416; GO:0048749; GO:0005829; GO:0046331; GO:0045475; GO:0007067; GO:0031397; GO:0005634; GO:0007228; GO:0045880; GO:0005956; GO:0004674; GO:0031647 P13098 ATP binding; Wnt receptor signaling pathway; axon guidance; chaeta development; compound eye development; cytosol; lateral inhibition; locomotor rhythm; mitosis; negative regulation of protein ubiquitination; nucleus; positive regulation of hh target transcription factor activity; positive regulation of smoothened signaling pathway; protein kinase CK2 complex; protein serine/threonine kinase activity; regulation of protein stability IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Casein kinase II subunit alpha (CK II subunit alpha) (EC 2.7.11.1) CkIIalpha Cask-II-a CG17520 Drosophila melanogaster (Fruit fly) TR17022_c0_g2_i1 Q7TSJ6 LATS2_MOUSE 1.00E-59 GO:0005524; GO:0000082; GO:0051301; GO:0034613; GO:0005737; GO:0035329; GO:0009755; GO:0007243; GO:0030216; GO:0046872; GO:0005815; GO:0007067; GO:0090090; GO:0045736; GO:0005634; GO:0004674; GO:0046620; GO:0000922 ATP binding; G1/S transition of mitotic cell cycle; cell division; cellular protein localization; cytoplasm; hippo signaling cascade; hormone-mediated signaling pathway; intracellular protein kinase cascade; keratinocyte differentiation; metal ion binding; microtubule organizing center; mitosis; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of cyclin-dependent protein serine/threonine kinase activity; nucleus; protein serine/threonine kinase activity; regulation of organ growth; spindle pole IPR000961; IPR011009; IPR017892; IPR000719; IPR017441; IPR002290; IPR008271; IPR009060; IPR015940; Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) Lats2 Mus musculus (Mouse) TR17023_c2_g1_i1 Q803Q4 DEP1A_DANRE 3.00E-11 GO:0005096; GO:0005622; GO:0035556; GO:0043547 GTPase activator activity; intracellular; intracellular signal transduction; positive regulation of GTPase activity IPR000591; IPR008936; IPR000198; IPR011991; DEP domain-containing protein 1A depdc1a Danio rerio (Zebrafish) (Brachydanio rerio) TR17023_c2_g2_i1 Q803Q4 DEP1A_DANRE 8.00E-12 GO:0005096; GO:0005622; GO:0035556; GO:0043547 GTPase activator activity; intracellular; intracellular signal transduction; positive regulation of GTPase activity IPR000591; IPR008936; IPR000198; IPR011991; DEP domain-containing protein 1A depdc1a Danio rerio (Zebrafish) (Brachydanio rerio) TR17029_c1_g1_i1 Q921A4 CYGB_RAT 8.00E-06 GO:0005737; GO:0020037; GO:0005506; GO:0043005; GO:0043025; GO:0019825; GO:0005344; GO:0004601; GO:0006979 cytoplasm; heme binding; iron ion binding; neuron projection; neuronal cell body; oxygen binding; oxygen transporter activity; peroxidase activity; response to oxidative stress IPR000971; IPR009050; IPR012292; IPR013314; Cytoglobin (Histoglobin) (HGb) (Stellate cell activation-associated protein) Cygb Stap Rattus norvegicus (Rat) TR17038_c0_g1_i1 Q9XS41 SODM_HORSE 5.00E-35 GO:0001315; GO:0030145; GO:0005759; GO:0006357; GO:0004784; GO:0006801 age-dependent response to reactive oxygen species; manganese ion binding; mitochondrial matrix; regulation of transcription from RNA polymerase II promoter; superoxide dismutase activity; superoxide metabolic process IPR001189; IPR019833; IPR019832; IPR019831; "Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1) (Mn-SOD)" SOD2 Equus caballus (Horse) TR17038_c1_g1_i1 P41982 SODM_RABIT 2.00E-34 GO:0030145; GO:0005759; GO:0004784; GO:0006801 manganese ion binding; mitochondrial matrix; superoxide dismutase activity; superoxide metabolic process IPR001189; IPR019833; IPR019832; IPR019831; "Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1) (Fragment)" SOD2 Oryctolagus cuniculus (Rabbit) TR17040_c1_g1_i1 P12839 NFM_RAT 3.00E-11 GO:0030424; GO:0005856; GO:0005882; GO:0005198 axon; cytoskeleton; intermediate filament; structural molecule activity IPR001664; IPR006821; IPR018039; IPR002957; Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) Nefm Nef3 Nfm Rattus norvegicus (Rat) TR17040_c1_g2_i1 P48677 GFAP_CARAU 3.00E-12 GO:0005882; GO:0005198 intermediate filament; structural molecule activity IPR001664; IPR018039; IPR002957; Glial fibrillary acidic protein (GFAP) (Fragment) gfap Carassius auratus (Goldfish) TR17040_c2_g1_i1 Q01240 NF60_LOLPE 1.00E-70 GO:0005882; GO:0005198 intermediate filament; structural molecule activity IPR001664; IPR016451; IPR018039; 60 kDa neurofilament protein (NF60) Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR17041_c2_g1_i1 Q8IXJ9 ASXL1_HUMAN 1.00E-12 GO:0003677; GO:0035517; GO:0060348; GO:0046872; GO:0035522; GO:0045599; GO:0035359; GO:0048387; GO:0000122; GO:0000790; GO:0042975; GO:0048386; GO:0045944; GO:0032526; GO:0042974; GO:0003713; GO:0003714; GO:0006351 P31749; Q92560; P45973; O75530; P03372; Q15910; O60341; P10276; P28700; P68306 "DNA binding; PR-DUB complex; bone development; metal ion binding; monoubiquitinated histone H2A deubiquitination; negative regulation of fat cell differentiation; negative regulation of peroxisome proliferator activated receptor signaling pathway; negative regulation of retinoic acid receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; peroxisome proliferator activated receptor binding; positive regulation of retinoic acid receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; response to retinoic acid; retinoic acid receptor binding; transcription coactivator activity; transcription corepressor activity; transcription, DNA-dependent" IPR026905; IPR024811; IPR028020; IPR024815; IPR007759; Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1) ASXL1 KIAA0978 Homo sapiens (Human) TR17043_c1_g2_i1 Q4WMV5 FKBP4_ASPFU 3.00E-08 GO:0005528; GO:0000412; GO:0005730; GO:0003755; GO:0006457 FK506 binding; histone peptidyl-prolyl isomerization; nucleolus; peptidyl-prolyl cis-trans isomerase activity; protein folding IPR026257; IPR023566; IPR001179; FK506-binding protein 4 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) fpr4 AFUA_6G08580 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) TR17043_c1_g3_i1 Q54N80 FKBP3_DICDI 4.00E-13 GO:0005528; GO:0016021; GO:0016020; GO:0007275; GO:0003755; GO:0006457 FK506 binding; integral to membrane; membrane; multicellular organismal development; peptidyl-prolyl cis-trans isomerase activity; protein folding IPR023566; IPR001179; FK506-binding protein 3 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) fkbp3 impA DDB_G0285455 Dictyostelium discoideum (Slime mold) TR1705_c0_g1_i1 P18172 DHGL_DROPS 3.00E-09 GO:0006066; GO:0008812; GO:0005576; GO:0050660 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR17051_c1_g1_i1 P0CS66 AKR1_CRYNJ 1.00E-11 GO:0000139; GO:0031901; GO:0016021; GO:0016746; GO:0008270 "Golgi membrane; early endosome membrane; integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR002110; IPR020683; IPR001594; Palmitoyltransferase AKR1 (EC 2.3.1.225) (Ankyrin repeat-containing protein AKR1) AKR1 CNA04190 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR17051_c1_g2_i1 Q5Y5T5 ZDHC8_MOUSE 9.00E-48 GO:0030659; GO:0016021; GO:0007626; GO:0005739; GO:0048471; GO:0016746; GO:0008270 "cytoplasmic vesicle membrane; integral to membrane; locomotory behavior; mitochondrion; perinuclear region of cytoplasm; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) Zdhhc8 Mus musculus (Mouse) TR17053_c0_g1_i1 Q5XG64 CV032_XENLA 2.00E-14 GO:0016021; GO:0005739 integral to membrane; mitochondrion IPR018782; "Single-pass membrane protein with aspartate-rich tail 1, mitochondrial" smdt1 Xenopus laevis (African clawed frog) TR17073_c0_g1_i1 Q8N2E2 VWDE_HUMAN 2.00E-09 GO:0005576 extracellular region IPR000742; IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) TR17074_c0_g2_i1 Q7ZV84 DAAF1_DANRE 8.00E-25 GO:0035085; GO:0060271; GO:0045502; GO:0044458 cilium axoneme; cilium morphogenesis; dynein binding; motile cilium assembly IPR027734; IPR001611; "Dynein assembly factor 1, axonemal (Leucine-rich repeat-containing protein 50)" dnaaf1 lrrc50 zgc:56169 Danio rerio (Zebrafish) (Brachydanio rerio) TR17080_c0_g1_i1 O35186 CATK_RAT 5.00E-38 GO:0045453; GO:0008234; GO:0005615; GO:0001957; GO:0005764; GO:0006508 bone resorption; cysteine-type peptidase activity; extracellular space; intramembranous ossification; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR015644; IPR013201; Cathepsin K (EC 3.4.22.38) Ctsk Rattus norvegicus (Rat) TR17080_c0_g2_i1 P55097 CATK_MOUSE 2.00E-38 GO:0045453; GO:0008234; GO:0005615; GO:0001957; GO:0005764; GO:0006508 bone resorption; cysteine-type peptidase activity; extracellular space; intramembranous ossification; lysosome; proteolysis IPR000169; IPR025660; IPR013128; IPR000668; IPR015644; IPR013201; Cathepsin K (EC 3.4.22.38) Ctsk Mus musculus (Mouse) TR17080_c1_g1_i1 P12399 CTL2A_MOUSE 6.00E-06 GO:0008234; GO:0030425; GO:0005576; GO:0050728; GO:0010955; GO:0045589 cysteine-type peptidase activity; dendrite; extracellular region; negative regulation of inflammatory response; negative regulation of protein processing; regulation of regulatory T cell differentiation IPR013128; IPR013201; Protein CTLA-2-alpha (Cytotoxic T-lymphocyte-associated protein 2-alpha) Ctla2a Mus musculus (Mouse) TR17083_c0_g1_i1 Q6DIB5 MEG10_MOUSE 4.00E-29 GO:0016323; GO:0042995; GO:0034109; GO:0016021; GO:0055001; GO:0001891; GO:0043654; GO:0051147; GO:0048641; GO:0014719; GO:0014816; GO:0014841 basolateral plasma membrane; cell projection; homotypic cell-cell adhesion; integral to membrane; muscle cell development; phagocytic cup; recognition of apoptotic cell; regulation of muscle cell differentiation; regulation of skeletal muscle tissue development; satellite cell activation; satellite cell differentiation; satellite cell proliferation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) TR17090_c1_g1_i1 Q8BLQ7 CTR4_MOUSE 4.00E-31 GO:0015171; GO:0016021 amino acid transmembrane transporter activity; integral to membrane IPR002293; Cationic amino acid transporter 4 (CAT-4) (CAT4) (Solute carrier family 7 member 4) Slc7a4 Mus musculus (Mouse) TR1710_c0_g1_i1 Q9FWW9 GSXL2_ARATH 2.00E-15 GO:0004499; GO:0050661; GO:0050832; GO:0050660 "N,N-dimethylaniline monooxygenase activity; NADP binding; defense response to fungus; flavin adenine dinucleotide binding" IPR000960; IPR020946; Flavin-containing monooxygenase FMO GS-OX-like 2 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 2) At1g12200 T28K15.7 Arabidopsis thaliana (Mouse-ear cress) TR17105_c1_g1_i1 Q460N5 PAR14_HUMAN 3.00E-19 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR17106_c0_g1_i1 Q90511 EI2BB_TAKRU 3.00E-156 GO:0005524; GO:0005525; GO:0051716; GO:0005851; GO:0005085; GO:0042552; GO:0014003; GO:0006446; GO:0003743; GO:0006413 ATP binding; GTP binding; cellular response to stimulus; eukaryotic translation initiation factor 2B complex; guanyl-nucleotide exchange factor activity; myelination; oligodendrocyte development; regulation of translational initiation; translation initiation factor activity; translational initiation IPR000649; Translation initiation factor eIF-2B subunit beta (S20I15) (eIF-2B GDP-GTP exchange factor subunit beta) eif2b2 eif2bb Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR17111_c0_g1_i1 Q8TF45 ZN418_HUMAN 2.00E-20 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 418 ZNF418 KIAA1956 Homo sapiens (Human) TR17111_c0_g2_i1 O43298 ZBT43_HUMAN 5.00E-10 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 43 (Zinc finger and BTB domain-containing protein 22B) (Zinc finger protein 297B) (ZnF-x) ZBTB43 KIAA0414 ZBTB22B ZNF297B Homo sapiens (Human) TR17116_c1_g1_i1 Q8TCN5 ZN507_HUMAN 1.00E-19 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 507 ZNF507 KIAA1084 Homo sapiens (Human) TR17116_c4_g1_i1 Q68EA5 ZNF57_HUMAN 4.00E-14 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 57 (Zinc finger protein 424) ZNF57 ZNF424 Homo sapiens (Human) TR17117_c1_g1_i1 Q98982 NK1R_LITCT 4.00E-35 GO:0016021; GO:0005886; GO:0004995; GO:0007217 integral to membrane; plasma membrane; tachykinin receptor activity; tachykinin receptor signaling pathway IPR000276; IPR017452; IPR001681; IPR000046; Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1) TACR1 TAC1R Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) TR17120_c0_g1_i1 A0JMD4 TPC2_DANRE 1.00E-19 GO:0072345; GO:0016021; GO:0005765; GO:0006939; GO:0005245 NAADP-sensitive calcium-release channel activity; integral to membrane; lysosomal membrane; smooth muscle contraction; voltage-gated calcium channel activity IPR027359; IPR005821; Two pore calcium channel protein 2 (Voltage-dependent calcium channel protein TPC2) tpcn2 tpc2 zgc:152898 Danio rerio (Zebrafish) (Brachydanio rerio) TR17129_c0_g1_i1 B2RXS4 PLXB2_MOUSE 1.00E-10 GO:0007420; GO:0005887; GO:0005622; GO:0001843; GO:0007405; GO:0050772; GO:0032319; GO:0008360; GO:2001222; GO:0001932; GO:0017154 Q68FM7 brain development; integral to plasma membrane; intracellular; neural tube closure; neuroblast proliferation; positive regulation of axonogenesis; regulation of Rho GTPase activity; regulation of cell shape; regulation of neuron migration; regulation of protein phosphorylation; semaphorin receptor activity IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-B2 Plxnb2 Mus musculus (Mouse) TR17131_c0_g1_i1 Q5U4T7 BIC1B_XENLA 2.00E-26 GO:0003723; GO:0007275 RNA binding; multicellular organismal development IPR004087; IPR004088; IPR001660; IPR013761; IPR021129; Protein bicaudal C homolog 1-B (Bic-C-B) bicc1-b Xenopus laevis (African clawed frog) TR17133_c0_g1_i1 O93430 GLRA1_DANRE 2.00E-35 GO:0030054; GO:0034707; GO:0016934; GO:0016594; GO:0005887; GO:0045211; GO:0022824 cell junction; chloride channel complex; extracellular-glycine-gated chloride channel activity; glycine binding; integral to plasma membrane; postsynaptic membrane; transmitter-gated ion channel activity IPR006028; IPR008127; IPR008128; IPR006202; IPR006201; IPR006029; IPR018000; Glycine receptor subunit alphaZ1 glra1 Danio rerio (Zebrafish) (Brachydanio rerio) TR17133_c2_g1_i1 O09028 GBRP_RAT 1.00E-17 GO:0004890; GO:0030054; GO:0005254; GO:0034707; GO:0005230; GO:0045211 GABA-A receptor activity; cell junction; chloride channel activity; chloride channel complex; extracellular ligand-gated ion channel activity; postsynaptic membrane IPR006028; IPR008100; IPR006202; IPR006201; IPR006029; IPR018000; Gamma-aminobutyric acid receptor subunit pi (GABA(A) receptor subunit pi) Gabrp Rattus norvegicus (Rat) TR17134_c0_g1_i1 P48166 RL44_CAEEL 2.00E-53 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000552; IPR011332; 60S ribosomal protein L44 (L41) rpl-41 C09H10.2 Caenorhabditis elegans TR17137_c0_g1_i1 Q8WW62 TMED6_HUMAN 1.00E-10 GO:0005789; GO:0016021; GO:0006810 endoplasmic reticulum membrane; integral to membrane; transport IPR009038; Transmembrane emp24 domain-containing protein 6 (p24 family protein gamma-5) (p24gamma5) TMED6 UNQ9146/PRO34237 Homo sapiens (Human) TR17146_c1_g2_i1 Q863A5 DYXC1_GORGO 1.00E-101 GO:0005737; GO:0030331; GO:0001764; GO:0005634; GO:0033146; GO:0061136 cytoplasm; estrogen receptor binding; neuron migration; nucleus; regulation of intracellular estrogen receptor signaling pathway; regulation of proteasomal protein catabolic process IPR007052; IPR008978; IPR013026; IPR011990; IPR001440; IPR019734; Dyslexia susceptibility 1 candidate gene 1 protein homolog DYX1C1 EKN1 Gorilla gorilla gorilla (Lowland gorilla) TR17150_c2_g1_i1 Q52KB6 C2CD3_MOUSE 4.00E-20 GO:0007420; GO:0005814; GO:0036064; GO:0042733; GO:0001947; GO:0001701; GO:0021997; GO:0021915; GO:0035058; GO:0016485; GO:0030162; GO:0008589 brain development; centriole; cilium basal body; embryonic digit morphogenesis; heart looping; in utero embryonic development; neural plate axis specification; neural tube development; nonmotile primary cilium assembly; protein processing; regulation of proteolysis; regulation of smoothened signaling pathway IPR000008; C2 domain-containing protein 3 (Protein hearty) C2cd3 Hty Mus musculus (Mouse) TR17153_c1_g1_i1 P81140 GCDH_PIG 5.00E-22 GO:0003995; GO:0050660; GO:0005759; GO:0006568 acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; mitochondrial matrix; tryptophan metabolic process IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Amino-acid metabolism; lysine degradation. Amino-acid metabolism; tryptophan metabolism. "Glutaryl-CoA dehydrogenase, mitochondrial (GCD) (EC 1.3.8.6) (Fragment)" GCDH Sus scrofa (Pig) TR17157_c0_g1_i1 Q9NUV9 GIMA4_HUMAN 2.00E-22 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR17161_c1_g1_i1 Q8CIG3 KDM1B_MOUSE 6.00E-10 GO:0003677; GO:0043046; GO:0050660; GO:0034648; GO:0034649; GO:0007275; GO:0005634; GO:0016491; GO:0044030; GO:0006349; GO:0006355; GO:0006351; GO:0008270 "DNA binding; DNA methylation involved in gamete generation; flavin adenine dinucleotide binding; histone demethylase activity (H3-dimethyl-K4 specific); histone demethylase activity (H3-monomethyl-K4 specific); multicellular organismal development; nucleus; oxidoreductase activity; regulation of DNA methylation; regulation of gene expression by genetic imprinting; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR002937; IPR009057; IPR016040; IPR007526; IPR011991; IPR011124; Lysine-specific histone demethylase 1B (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 2) Kdm1b Aof1 Lsd2 Mus musculus (Mouse) TR17168_c0_g1_i1 P18715 ZG26_XENLA 2.00E-29 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Gastrula zinc finger protein XlCGF26.1 (Fragment) Xenopus laevis (African clawed frog) TR17169_c1_g1_i1 Q12908 NTCP2_HUMAN 3.00E-44 GO:0016324; GO:0008206; GO:0008508; GO:0005887; GO:0005634; GO:0000502 apical plasma membrane; bile acid metabolic process; bile acid:sodium symporter activity; integral to plasma membrane; nucleus; proteasome complex IPR004710; IPR002657; "Ileal sodium/bile acid cotransporter (Apical sodium-dependent bile acid transporter) (ASBT) (Ileal Na(+)/bile acid cotransporter) (Ileal sodium-dependent bile acid transporter) (IBAT) (ISBT) (Na(+)-dependent ileal bile acid transporter) (Sodium/taurocholate cotransporting polypeptide, ileal) (Solute carrier family 10 member 2)" SLC10A2 ASBT ISBT NTCP2 Homo sapiens (Human) TR17171_c0_g1_i1 O15439 MRP4_HUMAN 3.00E-30 GO:0016404; GO:0005524; GO:0006200; GO:0042626; GO:0016021; GO:0005886; GO:0030168; GO:0002576; GO:0031088; GO:0055085 "15-hydroxyprostaglandin dehydrogenase (NAD+) activity; ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; plasma membrane; platelet activation; platelet degranulation; platelet dense granule membrane; transmembrane transport" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) ABCC4 MRP4 Homo sapiens (Human) TR17179_c0_g1_i1 O16925 STDH4_CAEEL 2.00E-15 GO:0016491; GO:0006694 oxidoreductase activity; steroid biosynthetic process IPR002198; IPR002347; IPR016040; IPR020904; Putative steroid dehydrogenase 4 (EC 1.1.1.-) stdh-4 tag-57 F25G6.5 Caenorhabditis elegans TR17179_c2_g1_i1 Q5R7K0 HSDL1_PONAB 6.00E-46 GO:0005739; GO:0055114; GO:0016491 mitochondrion; oxidation-reduction process; oxidoreductase activity IPR002198; IPR002347; IPR016040; Inactive hydroxysteroid dehydrogenase-like protein 1 HSDL1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR17184_c0_g1_i1 Q9JKZ2 SC5A3_MOUSE 7.00E-29 GO:0006020; GO:0016021; GO:0015798; GO:0007422; GO:0043576; GO:0006814; GO:0015293 inositol metabolic process; integral to membrane; myo-inositol transport; peripheral nervous system development; regulation of respiratory gaseous exchange; sodium ion transport; symporter activity IPR001734; IPR018212; IPR019900; Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3) Slc5a3 Mus musculus (Mouse) TR17187_c0_g1_i1 P35129 UBC2_CAEEL 6.00E-77 GO:0005524; GO:0042787; GO:0004842 ATP binding; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 2 (EC 6.3.2.19) (Lethal protein 70) (Ubiquitin carrier protein 2) (Ubiquitin-protein ligase 2) let-70 ubc-2 M7.1 Caenorhabditis elegans TR17187_c1_g2_i1 P25867 UBCD1_DROME 1.00E-12 GO:0005524; GO:0051276; GO:0001751; GO:0008054; GO:0048132; GO:0030718; GO:0007140; GO:0005875; GO:0007067; GO:0016322; GO:0045676; GO:0031647; GO:0007286; GO:0004842 ATP binding; chromosome organization; compound eye photoreceptor cell differentiation; cyclin catabolic process; female germ-line stem cell division; germ-line stem cell maintenance; male meiosis; microtubule associated complex; mitosis; neuron remodeling; regulation of R7 cell differentiation; regulation of protein stability; spermatid development; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2-17 kDa (EC 6.3.2.19) (Protein effete) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) eff UbcD1 CG7425 Drosophila melanogaster (Fruit fly) TR17189_c0_g1_i1 Q710E6 SUCO_RAT 1.00E-11 GO:0016021; GO:0016020; GO:0007275; GO:0001503; GO:0032967; GO:0045669; GO:0046850; GO:0005791; GO:0030867 integral to membrane; membrane; multicellular organismal development; ossification; positive regulation of collagen biosynthetic process; positive regulation of osteoblast differentiation; regulation of bone remodeling; rough endoplasmic reticulum; rough endoplasmic reticulum membrane IPR008979; IPR012919; SUN domain-containing ossification factor (Membrane protein CH1) (Protein osteopotentia homolog) (SUN-like protein 1) Suco Dd25 Opt Rattus norvegicus (Rat) TR17208_c2_g1_i1 Q7ZYA0 LMBD2_XENLA 3.00E-18 GO:0016021 integral to membrane IPR006876; LMBR1 domain-containing protein 2 lmbrd2 Xenopus laevis (African clawed frog) TR17208_c4_g1_i1 Q61ZW5 LMBD2_CAEBR 7.00E-08 GO:0016021 integral to membrane IPR006876; LMBR1 domain-containing protein 2 homolog CBG02934 Caenorhabditis briggsae TR17226_c0_g2_i1 O27188 MFNA_METTH 3.00E-11 GO:0009108; GO:0030170; GO:0004837; GO:0006570 coenzyme biosynthetic process; pyridoxal phosphate binding; tyrosine decarboxylase activity; tyrosine metabolic process IPR002129; IPR015424; IPR015421; IPR015422; IPR020931; Cofactor biosynthesis; methanofuran biosynthesis. L-tyrosine decarboxylase (TDC) (EC 4.1.1.25) mfnA MTH_1116 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) TR17226_c1_g1_i1 Q54RV9 SGPL_DICDI 5.00E-37 GO:0030036; GO:0001667; GO:0016831; GO:0019752; GO:0008219; GO:0006874; GO:0006672; GO:0006935; GO:0005789; GO:0016021; GO:0031158; GO:0031276; GO:0046956; GO:0030170; GO:0030833; GO:0030587; GO:0008117; GO:0030149; GO:0030435 actin cytoskeleton organization; ameboidal cell migration; carboxy-lyase activity; carboxylic acid metabolic process; cell death; cellular calcium ion homeostasis; ceramide metabolic process; chemotaxis; endoplasmic reticulum membrane; integral to membrane; negative regulation of aggregate size involved in sorocarp development; negative regulation of lateral pseudopodium assembly; positive phototaxis; pyridoxal phosphate binding; regulation of actin filament polymerization; sorocarp development; sphinganine-1-phosphate aldolase activity; sphingolipid catabolic process; sporulation resulting in formation of a cellular spore IPR002129; IPR015424; IPR015421; Lipid metabolism; sphingolipid metabolism. Sphingosine-1-phosphate lyase (S1P lyase) (S1PL) (SP-lyase) (SPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase) sglA DDB_G0282819 Dictyostelium discoideum (Slime mold) TR17229_c1_g2_i1 P27590 UROM_RAT 6.00E-06 GO:0005794; GO:0031225; GO:0016324; GO:0016323; GO:0005509; GO:0048878; GO:0060170; GO:0016023; GO:0007588; GO:0005615; GO:0045121; GO:0072218; GO:0072221; GO:0072233; GO:0072372; GO:2000021; GO:0010033; GO:0000922 Golgi apparatus; anchored to membrane; apical plasma membrane; basolateral plasma membrane; calcium ion binding; chemical homeostasis; cilium membrane; cytoplasmic membrane-bounded vesicle; excretion; extracellular space; membrane raft; metanephric ascending thin limb development; metanephric distal convoluted tubule development; metanephric thick ascending limb development; primary cilium; regulation of ion homeostasis; response to organic substance; spindle pole IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR023413; IPR009030; IPR001507; IPR017977; "Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]" Umod Rattus norvegicus (Rat) TR17233_c0_g1_i1 O43903 GAS2_HUMAN 1.00E-07 GO:0005884; GO:0007050; GO:0006921; GO:0005829; GO:0016020; GO:0008360 actin filament; cell cycle arrest; cellular component disassembly involved in execution phase of apoptosis; cytosol; membrane; regulation of cell shape IPR001715; IPR003108; Growth arrest-specific protein 2 (GAS-2) GAS2 Homo sapiens (Human) TR17239_c0_g1_i2 Q5RDA3 CSTF2_PONAB 6.00E-06 GO:0003723; GO:0071920; GO:0005847; GO:0006397; GO:0000166 RNA binding; cleavage body; mRNA cleavage and polyadenylation specificity factor complex; mRNA processing; nucleotide binding IPR025742; IPR026896; IPR012677; IPR000504; Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) CSTF2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR17243_c0_g1_i1 Q17754 TIM9_CAEEL 2.00E-11 GO:0046872; GO:0005743; GO:0045039; GO:0040014; GO:0000003 metal ion binding; mitochondrial inner membrane; protein import into mitochondrial inner membrane; regulation of multicellular organism growth; reproduction IPR004217; Mitochondrial import inner membrane translocase subunit Tim9 tin-9.1 tim9a tin-9 C06G3.11 Caenorhabditis elegans TR17244_c0_g1_i1 O60344 ECE2_HUMAN 1.00E-40 GO:0000139; GO:0007420; GO:0010002; GO:0007267; GO:0030659; GO:0016021; GO:0046872; GO:0004222; GO:0008168; GO:0016486; GO:0006508 Golgi membrane; brain development; cardioblast differentiation; cell-cell signaling; cytoplasmic vesicle membrane; integral to membrane; metal ion binding; metalloendopeptidase activity; methyltransferase activity; peptide hormone processing; proteolysis IPR024079; IPR013216; IPR000718; IPR018497; IPR008753; Endothelin-converting enzyme 2 (ECE-2) [Includes: Methyltransferase-like region (EC 2.1.1.-); Endothelin-converting enzyme 2 region (EC 3.4.24.71)] ECE2 KIAA0604 UNQ403/PRO740 Homo sapiens (Human) TR17246_c0_g2_i1 Q9CR47 NSA2_MOUSE 3.00E-142 GO:0005730; GO:0006364; GO:0030529 nucleolus; rRNA processing; ribonucleoprotein complex IPR022309; Ribosome biogenesis protein NSA2 homolog (L-name-related protein 42) (LNR42) (TGF-beta-inducible nuclear protein 1) Nsa2 Tinp1 Mus musculus (Mouse) TR17259_c0_g1_i1 P58428 ABCG8_RAT 5.00E-18 GO:0005524; GO:0043190; GO:0016887; GO:0016324; GO:0033344; GO:0042632; GO:0017127; GO:0007588; GO:0016021; GO:0045796; GO:0010949; GO:0030300; GO:0042493; GO:0007584 ATP binding; ATP-binding cassette (ABC) transporter complex; ATPase activity; apical plasma membrane; cholesterol efflux; cholesterol homeostasis; cholesterol transporter activity; excretion; integral to membrane; negative regulation of intestinal cholesterol absorption; negative regulation of intestinal phytosterol absorption; regulation of intestinal cholesterol absorption; response to drug; response to nutrient IPR003593; IPR013525; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family G member 8 (Sterolin-2) Abcg8 Rattus norvegicus (Rat) TR17259_c1_g1_i1 P33302 PDR5_YEAST 1.00E-11 GO:0005524; GO:0016021; GO:0005886; GO:0046677; GO:0046898; GO:0008559 ATP binding; integral to membrane; plasma membrane; response to antibiotic; response to cycloheximide; xenobiotic-transporting ATPase activity IPR003593; IPR013525; IPR003439; IPR017871; IPR027417; IPR010929; IPR005285; Pleiotropic ABC efflux transporter of multiple drugs (Pleiotropic drug resistance protein 5) (Suppressor of toxicity of sporidesmin) PDR5 LEM1 STS1 YDR1 YOR153W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR1728_c0_g1_i1 B6ZLK2 CHD1_CHICK 3.00E-21 GO:0005524; GO:0003677; GO:0000775; GO:0004386; GO:0005634; GO:0006355; GO:0006351 "ATP binding; DNA binding; chromosome, centromeric region; helicase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR023780; IPR000953; IPR016197; IPR023779; IPR025260; IPR014001; IPR001650; IPR027417; IPR000330; Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase CHD1) CHD1 Gallus gallus (Chicken) TR17283_c0_g1_i1 P29590 PML_HUMAN 3.00E-06 GO:0003677; GO:0006977; GO:0016605; GO:0030578; GO:0007184; GO:0006919; GO:0006915; GO:0060444; GO:0007050; GO:0045165; GO:0071353; GO:0090398; GO:0050897; GO:0007182; GO:0005737; GO:0005829; GO:0051607; GO:0031901; GO:0032469; GO:0042406; GO:0060333; GO:0008630; GO:0042771; GO:0051457; GO:0019048; GO:0030099; GO:0016525; GO:0030308; GO:0008285; GO:0045930; GO:2000059; GO:0051974; GO:0032211; GO:0045892; GO:0032938; GO:0016363; GO:0031965; GO:0005730; GO:0005634; GO:0060058; GO:0002230; GO:2001238; GO:0031065; GO:0043161; GO:0006461; GO:0046982; GO:0050821; GO:0006605; GO:0045343; GO:0010522; GO:2000779; GO:0001932; GO:0009411; GO:0010332; GO:0001666; GO:0048384; GO:0003713; GO:0006351; GO:0007179; GO:0008270 P03243-1; P04489; P27958; P68400; Q9UER7; P25445; Q9Y2M5; Q13164; Q00987; P25788; P63165; Q13207; O14746; Q15583; P04637; Q05516 "DNA binding; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; PML body; PML body organization; SMAD protein import into nucleus; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; branching involved in mammary gland duct morphogenesis; cell cycle arrest; cell fate commitment; cellular response to interleukin-4; cellular senescence; cobalt ion binding; common-partner SMAD protein phosphorylation; cytoplasm; cytosol; defense response to virus; early endosome membrane; endoplasmic reticulum calcium ion homeostasis; extrinsic to endoplasmic reticulum membrane; interferon-gamma-mediated signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; maintenance of protein location in nucleus; modulation by virus of host morphology or physiology; myeloid cell differentiation; negative regulation of angiogenesis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of mitotic cell cycle; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; negative regulation of telomerase activity; negative regulation of telomere maintenance via telomerase; negative regulation of transcription, DNA-dependent; negative regulation of translation in response to oxidative stress; nuclear matrix; nuclear membrane; nucleolus; nucleus; positive regulation of apoptotic process involved in mammary gland involution; positive regulation of defense response to virus by host; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of histone deacetylation; proteasomal ubiquitin-dependent protein catabolic process; protein complex assembly; protein heterodimerization activity; protein stabilization; protein targeting; regulation of MHC class I biosynthetic process; regulation of calcium ion transport into cytosol; regulation of double-strand break repair; regulation of protein phosphorylation; response to UV; response to gamma radiation; response to hypoxia; retinoic acid receptor signaling pathway; transcription coactivator activity; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; zinc ion binding" IPR021978; IPR000315; IPR001841; IPR013083; IPR017907; Protein PML (Promyelocytic leukemia protein) (RING finger protein 71) (Tripartite motif-containing protein 19) PML MYL PP8675 RNF71 TRIM19 Homo sapiens (Human) TR17293_c1_g1_i1 O57311 ZIC3_XENLA 1.00E-38 GO:0005737; GO:0007368; GO:0000578; GO:0046872; GO:0007399; GO:0014034; GO:0005634; GO:0045944; GO:0043565; GO:0003700; GO:0006351 "cytoplasm; determination of left/right symmetry; embryonic axis specification; metal ion binding; nervous system development; neural crest cell fate commitment; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein ZIC 3 (XZic3) (XlZic3) (Zinc finger protein Zic3-A) (Zinc finger protein of the cerebellum 3) zic3 zic3-a Xenopus laevis (African clawed frog) TR17293_c1_g2_i1 Q61467 ZIC4_MOUSE 5.00E-42 GO:0003677; GO:0046872; GO:0005634 DNA binding; metal ion binding; nucleus IPR007087; IPR015880; IPR013087; Zinc finger protein ZIC 4 (Zinc finger protein of the cerebellum 4) Zic4 Mus musculus (Mouse) TR17298_c0_g1_i1 P31792 POL_FENV1 3.00E-17 GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0075713; GO:0090305; GO:0004523; GO:0046718 DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; establishment of integrated proviral latency; nucleic acid phosphodiester bond hydrolysis; ribonuclease H activity; viral entry into host cell IPR001584; IPR012337; IPR002156; IPR000477; Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN)] (Fragment) pol Feline endogenous virus ECE1 TR17298_c0_g2_i1 O92815 POL_WDSV 6.00E-16 GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0020002; GO:0016020; GO:0090305; GO:0006508; GO:0004523; GO:0039660; GO:0019013; GO:0008270 DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; host cell plasma membrane; membrane; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; structural constituent of virion; viral nucleocapsid; zinc ion binding IPR001584; IPR018061; IPR021109; IPR012337; IPR002156; IPR000477; IPR001878; Gag-Pol polyprotein [Cleaved into: Matrix protein p10 (MA); p20; Capsid protein p25 (CA); Nucleocapsid protein p14 (NC-pol); Protease p15 (PR) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H p90 (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase p46 (IN)] gag-pol Walleye dermal sarcoma virus (WDSV) TR17304_c2_g1_i1 Q5UQV1 YR354_MIMIV 5.00E-06 GO:0003677; GO:0004518; GO:0090305 DNA binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis IPR011604; IPR017482; IPR011335; IPR019080; Uncharacterized protein R354 MIMI_R354 Acanthamoeba polyphaga mimivirus (APMV) TR17305_c2_g1_i1 O97394 SDK_DROME 1.00E-06 GO:0007155; GO:0042675; GO:0005887; GO:0046533; GO:0050931 cell adhesion; compound eye cone cell differentiation; integral to plasma membrane; negative regulation of photoreceptor cell differentiation; pigment cell differentiation IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Protein sidekick sdk CG5227 Drosophila melanogaster (Fruit fly) TR17316_c2_g1_i1 Q9CZJ2 HS12B_MOUSE 4.00E-19 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR17323_c1_g1_i1 Q7TM99 MOT9_MOUSE 2.00E-09 GO:0016021; GO:0005886; GO:0015293; GO:0046415 integral to membrane; plasma membrane; symporter activity; urate metabolic process IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) Slc16a9 Mct9 Mus musculus (Mouse) TR17328_c6_g1_i1 Q91318 CRBB2_LITCT 6.00E-09 GO:0005212 structural constituent of eye lens IPR001064; IPR011024; Beta-crystallin B2 (Beta-B2 crystallin) (Beta-crystallin Bp) Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) TR17329_c0_g1_i1 A8C750 THADA_CANFA 7.00E-20 IPR016024; IPR019442; Thyroid adenoma-associated protein homolog THADA Canis familiaris (Dog) (Canis lupus familiaris) TR17330_c1_g1_i1 Q05714 CRBB2_CHICK 4.00E-08 GO:0005212 structural constituent of eye lens IPR001064; IPR011024; Beta-crystallin B2 (Beta-B2 crystallin) (Beta-crystallin Bp) CRYBB2 Gallus gallus (Chicken) TR17330_c2_g1_i1 A4L9I8 CRBS_RABIT 5.00E-06 GO:0002088; GO:0002009; GO:0005212 lens development in camera-type eye; morphogenesis of an epithelium; structural constituent of eye lens IPR001064; IPR011024; Beta-crystallin S (Gamma-S-crystallin) (Gamma-crystallin S) CRYGS Oryctolagus cuniculus (Rabbit) TR17335_c0_g1_i1 P38542 RAN_BRUMA 6.00E-64 GO:0005525; GO:0003924; GO:0006886; GO:0006913; GO:0005634; GO:0007264 GTP binding; GTPase activity; intracellular protein transport; nucleocytoplasmic transport; nucleus; small GTPase mediated signal transduction IPR027417; IPR002041; IPR005225; IPR001806; GTP-binding nuclear protein Ran (GTPase Ran) (Ras-like protein TC4) Bm1_44725 Brugia malayi (Filarial nematode worm) TR17337_c2_g1_i1 Q80TB8 VAT1L_MOUSE 2.00E-38 GO:0016491; GO:0008270 oxidoreductase activity; zinc ion binding IPR013154; IPR002085; IPR011032; IPR016040; IPR002364; Synaptic vesicle membrane protein VAT-1 homolog-like (EC 1.-.-.-) Vat1l Kiaa1576 Mus musculus (Mouse) TR17341_c0_g1_i1 Q9CQ86 MIEN1_MOUSE 1.00E-06 GO:0006915; GO:0045454; GO:0005829; GO:0031235; GO:0043066; GO:0030335; GO:0051491; GO:0008430 apoptotic process; cell redox homeostasis; cytosol; intrinsic to internal side of plasma membrane; negative regulation of apoptotic process; positive regulation of cell migration; positive regulation of filopodium assembly; selenium binding IPR011893; IPR012336; Migration and invasion enhancer 1 Mien1 Rdx12 Mus musculus (Mouse) TR17353_c0_g1_i1 Q8K2X1 AT10D_MOUSE 6.00E-35 GO:0005524; GO:0006812; GO:0019829; GO:0005789; GO:0016021; GO:0000287; GO:0005739; GO:0004012; GO:0005886 ATP binding; cation transport; cation-transporting ATPase activity; endoplasmic reticulum membrane; integral to membrane; magnesium ion binding; mitochondrion; phospholipid-translocating ATPase activity; plasma membrane IPR023299; IPR018303; IPR006539; IPR008250; IPR001757; IPR023214; Probable phospholipid-transporting ATPase VD (EC 3.6.3.1) (ATPase class V type 10D) Atp10d Mus musculus (Mouse) TR17353_c3_g1_i1 F1Q4S1 ATP9B_DANRE 9.00E-09 GO:0005524; GO:0005794; GO:0019829; GO:0016021; GO:0000287; GO:0004012 ATP binding; Golgi apparatus; cation-transporting ATPase activity; integral to membrane; magnesium ion binding; phospholipid-translocating ATPase activity IPR023299; IPR018303; IPR006539; IPR008250; IPR001757; IPR023214; Probable phospholipid-transporting ATPase IIB (EC 3.6.3.1) (ATPase class II type 9B) atp9b Danio rerio (Zebrafish) (Brachydanio rerio) TR17353_c4_g1_i1 Q5BL50 AT8B1_XENTR 3.00E-15 GO:0005524; GO:0019829; GO:0005783; GO:0016021; GO:0000287; GO:0004012; GO:0005886 ATP binding; cation-transporting ATPase activity; endoplasmic reticulum; integral to membrane; magnesium ion binding; phospholipid-translocating ATPase activity; plasma membrane IPR023299; IPR018303; IPR006539; IPR008250; IPR001757; IPR023214; Probable phospholipid-transporting ATPase IC (EC 3.6.3.1) (ATPase class I type 8B member 1) atp8b1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR17359_c1_g1_i1 Q8N2E2 VWDE_HUMAN 3.00E-09 GO:0005576 extracellular region IPR000742; IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) TR17363_c0_g1_i1 Q5QD24 TAAR3_RAT 8.00E-09 GO:0016021; GO:0005886; GO:0007606; GO:0001594 integral to membrane; plasma membrane; sensory perception of chemical stimulus; trace-amine receptor activity IPR000276; IPR017452; IPR009132; Trace amine-associated receptor 3 (TaR-3) (Trace amine receptor 3) Taar3 Rattus norvegicus (Rat) TR17369_c1_g1_i1 B6LI37 U722_BRAFL 3.00E-16 UPF0722 protein BRAFLDRAFT_119565 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR17375_c0_g1_i1 Q07E02 CAV1_ORNAN 2.00E-06 GO:0000139; GO:0031295; GO:0005901; GO:0005768 Golgi membrane; T cell costimulation; caveola; endosome IPR001612; IPR015504; IPR018361; Caveolin-1 CAV1 Ornithorhynchus anatinus (Duckbill platypus) TR17378_c4_g1_i1 P45447 E78C_DROME 1.00E-35 GO:0004879; GO:0005634; GO:0043565; GO:0003707; GO:0008270 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleus; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Ecdysone-induced protein 78C (DR-78) (Nuclear receptor subfamily 1 group E member 1) Eip78C NR1E1 CG18023 Drosophila melanogaster (Fruit fly) TR1738_c0_g1_i1 P82595 PLS_HALLA 9.00E-11 GO:0005576; GO:0001558 extracellular region; regulation of cell growth IPR009030; IPR000867; IPR017891; Perlustrin Haliotis laevigata (Abalone) TR17382_c0_g1_i1 Q9UBQ5 EIF3K_HUMAN 4.00E-74 GO:0005829; GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0005634; GO:0006446; GO:0043022; GO:0003743; GO:0006413 Q9Q2G4 cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; nucleus; regulation of translational initiation; ribosome binding; translation initiation factor activity; translational initiation IPR016024; IPR009374; IPR016020; IPR011991; Eukaryotic translation initiation factor 3 subunit K (eIF3k) (Eukaryotic translation initiation factor 3 subunit 12) (Muscle-specific gene M9 protein) (PLAC-24) (eIF-3 p25) (eIF-3 p28) EIF3K EIF3S12 ARG134 HSPC029 MSTP001 PTD001 Homo sapiens (Human) TR17388_c0_g1_i1 Q24157 BRN_DROME 6.00E-11 GO:0000139; GO:0005795; GO:0007219; GO:0046981; GO:0007298; GO:0005576; GO:0047915; GO:0007293; GO:0006688; GO:0008314; GO:0016021; GO:0042248; GO:0001744; GO:0007299; GO:0006486 "Golgi membrane; Golgi stack; Notch signaling pathway; beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity; border follicle cell migration; extracellular region; ganglioside galactosyltransferase activity; germarium-derived egg chamber formation; glycosphingolipid biosynthetic process; gurken receptor signaling pathway; integral to membrane; maintenance of polarity of follicular epithelium; optic lobe placode formation; ovarian follicle cell-cell adhesion; protein glycosylation" IPR002659; "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) TR17403_c0_g1_i1 Q5TZE1 BTB6B_DANRE 5.00E-06 GO:0030154; GO:0000932; GO:0007399 cell differentiation; cytoplasmic mRNA processing body; nervous system development IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6-B btbd6b btbd6 si:dkey-11b8.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR1741_c0_g1_i1 Q9JLB5 ACH10_RAT 2.00E-09 GO:0004889; GO:0030424; GO:0005262; GO:0030054; GO:0007204; GO:0016021; GO:0043204; GO:0045211; GO:0007271 "acetylcholine-activated cation-selective channel activity; axon; calcium channel activity; cell junction; elevation of cytosolic calcium ion concentration; integral to membrane; perikaryon; postsynaptic membrane; synaptic transmission, cholinergic" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) Chrna10 Rattus norvegicus (Rat) TR17411_c0_g1_i1 Q0IJ20 RN145_XENTR 5.00E-15 GO:0016021; GO:0008270 integral to membrane; zinc ion binding IPR025754; IPR001841; IPR013083; RING finger protein 145 rnf145 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR17412_c1_g1_i1 Q9H4Z3 PCIF1_HUMAN 2.00E-35 GO:0015629; GO:0005825; GO:0010923; GO:0005634 actin cytoskeleton; half bridge of spindle pole body; negative regulation of phosphatase activity; nucleus IPR022035; IPR001202; Phosphorylated CTD-interacting factor 1 PCIF1 C20orf67 Homo sapiens (Human) TR17414_c2_g1_i1 Q9VCP0 ELOA1_DROME 9.00E-16 GO:0003677; GO:0070449; GO:0016021; GO:0007275; GO:0032968; GO:0006368 DNA binding; elongin complex; integral to membrane; multicellular organismal development; positive regulation of transcription elongation from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter IPR010684; IPR017923; Transcription elongation factor B polypeptide 3 (Elongin-A) (RNA polymerase II transcription factor SIII subunit A) (dEloA) EloA CG6755 Drosophila melanogaster (Fruit fly) TR17417_c0_g1_i1 P19848 UBIQ_COPCO 6.00E-25 GO:0005737; GO:0005634 cytoplasm; nucleus IPR019956; IPR019954; IPR000626; Ubiquitin Coprinus congregatus (Inky cap fungus) TR17420_c0_g1_i1 Q9IA76 RL31_PAROL 5.00E-59 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000054; IPR020052; IPR023621; 60S ribosomal protein L31 rpl31 Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus) TR17422_c0_g1_i1 P79781 RS27A_CHICK 3.00E-75 GO:0002755; GO:0035419; GO:0007250; GO:0022627; GO:0045087; GO:0046872; GO:0005654; GO:0003735; GO:0035681; GO:0034134; GO:0035682; GO:0034138; GO:0034142; GO:0034146; GO:0034154; GO:0006412; GO:0019985 MyD88-dependent toll-like receptor signaling pathway; activation of MAPK activity involved in innate immune response; activation of NF-kappaB-inducing kinase activity; cytosolic small ribosomal subunit; innate immune response; metal ion binding; nucleoplasm; structural constituent of ribosome; toll-like receptor 15 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 21 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 7 signaling pathway; translation; translesion synthesis IPR002906; IPR011332; IPR019956; IPR019954; IPR000626; Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a] RPS27A UBA80 Gallus gallus (Chicken) TR17429_c0_g1_i1 P86854 PLCL_MYTGA 3.00E-15 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR17429_c0_g2_i1 Q8HY04 CD209_PAPHA 2.00E-08 GO:0007155; GO:0006897; GO:0045087; GO:0016021; GO:0005537; GO:0046872 cell adhesion; endocytosis; innate immune response; integral to membrane; mannose binding; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; CD209 antigen (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN1) (CD antigen CD209) CD209 Papio hamadryas (Hamadryas baboon) TR17434_c1_g1_i1 Q8JJC0 ZIC1_CHICK 7.00E-23 GO:0003677; GO:0007610; GO:0030154; GO:0005737; GO:0042472; GO:0046872; GO:0005634; GO:0007389; GO:0008589; GO:0006355; GO:0021510; GO:0006351 "DNA binding; behavior; cell differentiation; cytoplasm; inner ear morphogenesis; metal ion binding; nucleus; pattern specification process; regulation of smoothened signaling pathway; regulation of transcription, DNA-dependent; spinal cord development; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein ZIC 1 (Zinc finger protein of the cerebellum 1) ZIC1 ZIC Gallus gallus (Chicken) TR17437_c0_g1_i1 Q9UHP6 RTDR1_HUMAN 3.00E-18 IPR011989; IPR016024; Rhabdoid tumor deletion region protein 1 RTDR1 Homo sapiens (Human) TR1744_c0_g1_i1 Q9H222 ABCG5_HUMAN 3.00E-12 GO:0005524; GO:0006200; GO:0016887; GO:0016324; GO:0033344; GO:0042632; GO:0017127; GO:0007588; GO:0016021; GO:0030299; GO:0045796; GO:0010949; GO:0042493; GO:0010212; GO:0007584; GO:0055085 Q9H221; P16333 ATP binding; ATP catabolic process; ATPase activity; apical plasma membrane; cholesterol efflux; cholesterol homeostasis; cholesterol transporter activity; excretion; integral to membrane; intestinal cholesterol absorption; negative regulation of intestinal cholesterol absorption; negative regulation of intestinal phytosterol absorption; response to drug; response to ionizing radiation; response to nutrient; transmembrane transport IPR003593; IPR013525; IPR003439; IPR027417; ATP-binding cassette sub-family G member 5 (Sterolin-1) ABCG5 Homo sapiens (Human) TR17440_c0_g1_i1 P25067 CO8A2_HUMAN 1.00E-06 GO:0001525; GO:0005604; GO:0048593; GO:0016337; GO:0005581; GO:0030574; GO:0005788; GO:0050673; GO:0022617; GO:0005201; GO:0030674 "angiogenesis; basement membrane; camera-type eye morphogenesis; cell-cell adhesion; collagen; collagen catabolic process; endoplasmic reticulum lumen; epithelial cell proliferation; extracellular matrix disassembly; extracellular matrix structural constituent; protein binding, bridging" IPR001073; IPR008160; IPR008983; Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) TR17440_c0_g2_i1 Q9ESN4 C1QL3_MOUSE 3.00E-06 GO:0005581; GO:0005576; GO:0050807 collagen; extracellular region; regulation of synapse organization IPR001073; IPR008160; IPR008983; Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13) (CTRP13) (Gliacolin) C1ql3 C1ql Ctrp13 Mus musculus (Mouse) TR17442_c0_g1_i1 Q0VGY8 TANC1_MOUSE 2.00E-13 GO:0043679; GO:0030054; GO:0030425; GO:0097062; GO:0007520; GO:0043025; GO:0014069; GO:0045211; GO:0008542 axon terminus; cell junction; dendrite; dendritic spine maintenance; myoblast fusion; neuronal cell body; postsynaptic density; postsynaptic membrane; visual learning IPR002110; IPR020683; IPR027417; IPR013026; IPR011990; IPR013105; IPR019734; "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" Tanc1 Mus musculus (Mouse) TR17444_c0_g1_i1 P20825 POL2_DROME 1.00E-49 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR17449_c0_g1_i1 Q6ZS30 NBEL1_HUMAN 1.00E-11 IPR016024; IPR000409; IPR008985; IPR026916; IPR023362; IPR015943; IPR001680; IPR017986; Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) NBEAL1 ALS2CR16 ALS2CR17 Homo sapiens (Human) TR17451_c2_g1_i1 Q9VB31 C6A18_DROME 2.00E-20 GO:0005789; GO:0020037; GO:0005506; GO:0004497; GO:0016705 "endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Probable cytochrome P450 6a18 (EC 1.14.-.-) (CYPVIA18) Cyp6a18 CG13977 Drosophila melanogaster (Fruit fly) TR17454_c3_g1_i1 Q7Z7M0 MEGF8_HUMAN 2.00E-28 GO:0005509; GO:0071907; GO:0061371; GO:0016021; GO:0005634; GO:0004872; GO:0005198 O15265; O00555 calcium ion binding; determination of digestive tract left/right asymmetry; determination of heart left/right asymmetry; integral to membrane; nucleus; receptor activity; structural molecule activity IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR002049; IPR015915; IPR016201; IPR002165; Multiple epidermal growth factor-like domains protein 8 (Multiple EGF-like domains protein 8) (Epidermal growth factor-like protein 4) (EGF-like protein 4) MEGF8 C19orf49 EGFL4 KIAA0817 Homo sapiens (Human) TR17458_c1_g1_i1 A0RQR9 HLDE_CAMFF 1.00E-33 GO:0097171; GO:0005524; GO:0033785; GO:0033786; GO:0016773 "ADP-L-glycero-beta-D-manno-heptose biosynthetic process; ATP binding; heptose 7-phosphate kinase activity; heptose-1-phosphate adenylyltransferase activity; phosphotransferase activity, alcohol group as acceptor" IPR023030; IPR004821; IPR011611; IPR011913; IPR011914; IPR014729; Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4. Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4. Bifunctional protein HldE [Includes: D-beta-D-heptose 7-phosphate kinase (EC 2.7.1.167) (D-beta-D-heptose 7-phosphotransferase) (D-glycero-beta-D-manno-heptose-7-phosphate kinase); D-beta-D-heptose 1-phosphate adenylyltransferase (EC 2.7.7.70) (D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase)] hldE CFF8240_1413 Campylobacter fetus subsp. fetus (strain 82-40) TR17469_c0_g1_i1 Q6GQB9 EDEM3_XENLA 3.00E-136 GO:0005509; GO:0005788; GO:0004571; GO:0016020; GO:0006986 "calcium ion binding; endoplasmic reticulum lumen; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; membrane; response to unfolded protein" IPR001382; IPR003137; "ER degradation-enhancing alpha-mannosidase-like protein 3 (EC 3.2.1.113) (Alpha-1,2-mannosidase EDEM3)" edem3 Xenopus laevis (African clawed frog) TR17474_c2_g1_i1 Q8BGY9 SC5A7_MOUSE 1.00E-17 GO:0008292; GO:0033265; GO:0015220; GO:0005307; GO:0016021; GO:0007274; GO:0043025; GO:0005886; GO:0007271 P05067 "acetylcholine biosynthetic process; choline binding; choline transmembrane transporter activity; choline:sodium symporter activity; integral to membrane; neuromuscular synaptic transmission; neuronal cell body; plasma membrane; synaptic transmission, cholinergic" IPR001734; High affinity choline transporter 1 (Hemicholinium-3-sensitive choline transporter) (CHT) (Solute carrier family 5 member 7) Slc5a7 Cht1 Mus musculus (Mouse) TR17478_c1_g2_i1 Q96MD7 CI085_HUMAN 2.00E-06 IPR019351; Uncharacterized protein C9orf85 C9orf85 Homo sapiens (Human) TR17483_c1_g1_i1 Q9WUU9 MCM3A_MOUSE 2.00E-15 GO:0005737; GO:0005829; GO:0005634 cytoplasm; cytosol; nucleus IPR005062; Germinal-center associated nuclear protein (GANP) (GC-associated DNA primase) Mcm3ap Ganp Map80 Mus musculus (Mouse) TR17487_c0_g1_i1 Q02369 NDUB9_BOVIN 3.00E-25 GO:0005747; GO:0055114 mitochondrial respiratory chain complex I; oxidation-reduction process IPR008011; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (Complex I-B22) (CI-B22) (NADH-ubiquinone oxidoreductase B22 subunit) NDUFB9 UQOR22 Bos taurus (Bovine) TR17488_c1_g1_i1 Q6V0I7 FAT4_HUMAN 5.00E-06 GO:0005509; GO:0007156; GO:0016021; GO:0005886 Q9H2K2 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) TR17489_c0_g1_i1 P12270 TPR_HUMAN 8.00E-06 GO:0005524; GO:0000189; GO:0006404; GO:0005975; GO:0051301; GO:0035457; GO:0003682; GO:0019221; GO:0005868; GO:0070840; GO:0019898; GO:0015758; GO:0031072; GO:0000776; GO:0003729; GO:0031990; GO:0051019; GO:0007067; GO:0007077; GO:0072686; GO:0007094; GO:0046832; GO:0000122; GO:0045947; GO:0042405; GO:0031965; GO:0034399; GO:0044615; GO:0006999; GO:0005487; GO:0005654; GO:0031453; GO:0090267; GO:0046827; GO:0042307; GO:0042803; GO:0010827; GO:0010965; GO:1901673; GO:0070849; GO:0004828; GO:0006434; GO:0044281; GO:0055085; GO:0015631; GO:0016032 ATP binding; MAPK import into nucleus; RNA import into nucleus; carbohydrate metabolic process; cell division; cellular response to interferon-alpha; chromatin binding; cytokine-mediated signaling pathway; cytoplasmic dynein complex; dynein complex binding; extrinsic to membrane; glucose transport; heat shock protein binding; kinetochore; mRNA binding; mRNA export from nucleus in response to heat stress; mitogen-activated protein kinase binding; mitosis; mitotic nuclear envelope disassembly; mitotic spindle; mitotic spindle assembly checkpoint; negative regulation of RNA export from nucleus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of translational initiation; nuclear inclusion body; nuclear membrane; nuclear periphery; nuclear pore nuclear basket; nuclear pore organization; nucleocytoplasmic transporter activity; nucleoplasm; positive regulation of heterochromatin assembly; positive regulation of mitotic cell cycle spindle assembly checkpoint; positive regulation of protein export from nucleus; positive regulation of protein import into nucleus; protein homodimerization activity; regulation of glucose transport; regulation of mitotic sister chromatid separation; regulation of spindle assembly involved in mitosis; response to epidermal growth factor stimulus; serine-tRNA ligase activity; seryl-tRNA aminoacylation; small molecule metabolic process; transmembrane transport; tubulin binding; viral process IPR015866; IPR012929; Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) TPR Homo sapiens (Human) TR17498_c1_g1_i1 P35561 IRK2_MOUSE 4.00E-23 GO:0030425; GO:0016021; GO:0031224; GO:0005242; GO:0015693; GO:0043025; GO:0051289; GO:0086001 Itself; P24588; B2RYN6; Q15700-4; Q2YHQ3 dendrite; integral to membrane; intrinsic to membrane; inward rectifier potassium channel activity; magnesium ion transport; neuronal cell body; protein homotetramerization; regulation of cardiac muscle cell action potential IPR014756; IPR016449; IPR003271; IPR013518; IPR013673; "Inward rectifier potassium channel 2 (Inward rectifier K(+) channel Kir2.1) (IRK-1) (Potassium channel, inwardly rectifying subfamily J member 2)" Kcnj2 Irk1 Mus musculus (Mouse) TR17500_c2_g1_i1 Q05158 CSRP2_COTJA 2.00E-25 GO:0030154; GO:0007275; GO:0005634; GO:0008270 cell differentiation; multicellular organismal development; nucleus; zinc ion binding IPR001781; Cysteine and glycine-rich protein 2 (Cysteine-rich protein 2) (CRP2) CSRP2 Coturnix coturnix japonica (Japanese quail) (Coturnix japonica) TR17500_c3_g1_i1 Q24400 MLP2_DROME 7.00E-21 GO:0030018; GO:0007517; GO:0060537; GO:0005634; GO:0090175; GO:0045214; GO:0008307; GO:0008270 Z disc; muscle organ development; muscle tissue development; nucleus; regulation of establishment of planar polarity; sarcomere organization; structural constituent of muscle; zinc ion binding IPR001781; Muscle LIM protein Mlp84B Mlp84B LIM3 CG10699 Drosophila melanogaster (Fruit fly) TR17501_c0_g1_i1 P54145 AMT1_CAEEL 5.00E-32 GO:0008519; GO:0016021 ammonium transmembrane transporter activity; integral to membrane IPR001905; IPR018047; IPR024041; Putative ammonium transporter 1 amt-1 C05E11.4 Caenorhabditis elegans TR17501_c0_g1_i2 P54145 AMT1_CAEEL 9.00E-40 GO:0008519; GO:0016021 ammonium transmembrane transporter activity; integral to membrane IPR001905; IPR018047; IPR024041; Putative ammonium transporter 1 amt-1 C05E11.4 Caenorhabditis elegans TR17520_c1_g1_i1 Q8N539 FBCD1_HUMAN 3.00E-46 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 UNQ701/PRO1346 Homo sapiens (Human) TR17520_c1_g1_i2 Q95LU3 FBCD1_MACFA 2.00E-45 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR17526_c0_g1_i1 Q8HZM6 ANXA1_HORSE 7.00E-21 GO:0016323; GO:0005509; GO:0005544; GO:0005929; GO:0005737; GO:0005634; GO:0019834 basolateral plasma membrane; calcium ion binding; calcium-dependent phospholipid binding; cilium; cytoplasm; nucleus; phospholipase A2 inhibitor activity IPR001464; IPR018502; IPR018252; IPR002388; Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Lipocortin I) ANXA1 ANX1 Equus caballus (Horse) TR17528_c0_g1_i1 O89029 MATN4_MOUSE 1.00E-15 GO:0005576; GO:0048678 extracellular region; response to axon injury IPR000742; IPR013032; IPR000152; IPR009030; IPR019466; IPR002035; Matrilin-4 (MAT-4) Matn4 Mus musculus (Mouse) TR17531_c1_g2_i1 P34644 EAT4_CAEEL 7.00E-41 GO:0030054; GO:0016021; GO:0061096; GO:0006836; GO:0005886; GO:0043051; GO:0006814; GO:0015293; GO:0045202 cell junction; integral to membrane; negative regulation of turning behavior involved in mating; neurotransmitter transport; plasma membrane; regulation of pharyngeal pumping; sodium ion transport; symporter activity; synapse IPR011701; IPR020846; IPR016196; Probable vesicular glutamate transporter eat-4 (Abnormal pharyngeal pumping eat-4) eat-4 ZK512.6 Caenorhabditis elegans TR17534_c1_g1_i1 P14381 YTX2_XENLA 3.00E-29 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR17536_c2_g1_i1 Q13263 TIF1B_HUMAN 3.00E-12 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR17555_c0_g1_i1 P46023 GR101_LYMST 3.00E-15 GO:0016021; GO:0005886; GO:0016500 integral to membrane; plasma membrane; protein-hormone receptor activity IPR000276; IPR017452; IPR002131; IPR023415; IPR002172; IPR001611; IPR003591; IPR000372; G-protein coupled receptor GRL101 Lymnaea stagnalis (Great pond snail) TR17562_c1_g1_i1 Q11002 CANA_DROME 1.00E-13 GO:0021919; GO:0015629; GO:0005509; GO:0004198; GO:0042335; GO:0005737; GO:0008340; GO:0043025; GO:0006909; GO:0016540; GO:0006508 BMP signaling pathway involved in spinal cord dorsal/ventral patterning; actin cytoskeleton; calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cuticle development; cytoplasm; determination of adult lifespan; neuronal cell body; phagocytosis; protein autoprocessing; proteolysis IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-A (EC 3.4.22.-) (Calcium-activated neutral proteinase A) (CANP A) [Cleaved into: Calpain-A catalytic subunit] CalpA CG7563 Drosophila melanogaster (Fruit fly) TR17574_c0_g1_i1 Q9CZJ2 HS12B_MOUSE 2.00E-41 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR17578_c0_g1_i1 Q1M4T3 PSUG2_RHIL3 7.00E-35 GO:0016798; GO:0046872 "hydrolase activity, acting on glycosyl bonds; metal ion binding" IPR007342; Pseudouridine-5'-phosphate glycosidase 2 (PsiMP glycosidase 2) (EC 3.2.-.-) psuG2 pRL120175 Rhizobium leguminosarum bv. viciae (strain 3841) TR17582_c2_g1_i1 Q96RY7 IF140_HUMAN 1.00E-66 GO:0042384; GO:0035085; GO:0036064; GO:0030991; GO:0032391 cilium assembly; cilium axoneme; cilium basal body; intraflagellar transport particle A; photoreceptor connecting cilium IPR015943; IPR001680; IPR017986; Intraflagellar transport protein 140 homolog (WD and tetratricopeptide repeats protein 2) IFT140 KIAA0590 WDTC2 Homo sapiens (Human) TR17582_c2_g2_i1 Q96RY7 IF140_HUMAN 1.00E-66 GO:0042384; GO:0035085; GO:0036064; GO:0030991; GO:0032391 cilium assembly; cilium axoneme; cilium basal body; intraflagellar transport particle A; photoreceptor connecting cilium IPR015943; IPR001680; IPR017986; Intraflagellar transport protein 140 homolog (WD and tetratricopeptide repeats protein 2) IFT140 KIAA0590 WDTC2 Homo sapiens (Human) TR17592_c1_g1_i1 Q14315 FLNC_HUMAN 1.00E-15 GO:0030018; GO:0034329; GO:0043034; GO:0005856; GO:0005829; GO:0048747; GO:0042383; GO:0016528 P00519; P46108; O75923; P62993; Q9UBF9 Z disc; cell junction assembly; costamere; cytoskeleton; cytosol; muscle fiber development; sarcolemma; sarcoplasm IPR001589; IPR001715; IPR003961; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) FLNC ABPL FLN2 Homo sapiens (Human) TR17595_c1_g1_i1 P0CF52 KDM7B_DANRE 4.00E-67 GO:0071558; GO:0051864; GO:0032454; GO:0035575; GO:0030901; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "histone demethylase activity (H3-K27 specific); histone demethylase activity (H3-K36 specific); histone demethylase activity (H3-K9 specific); histone demethylase activity (H4-K20 specific); midbrain development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003347; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Lysine-specific demethylase 7B (DrKDM7b) (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 1D-B) jhdm1db kdm7b Danio rerio (Zebrafish) (Brachydanio rerio) TR17595_c2_g1_i1 P0CH95 PHF8_DANRE 7.00E-64 GO:0000082; GO:0007420; GO:0003682; GO:0071558; GO:0051864; GO:0032454; GO:0035575; GO:0035064; GO:0061188; GO:0005730; GO:0045943; GO:0006351; GO:0008270 "G1/S transition of mitotic cell cycle; brain development; chromatin binding; histone demethylase activity (H3-K27 specific); histone demethylase activity (H3-K36 specific); histone demethylase activity (H3-K9 specific); histone demethylase activity (H4-K20 specific); methylated histone residue binding; negative regulation of chromatin silencing at rDNA; nucleolus; positive regulation of transcription from RNA polymerase I promoter; transcription, DNA-dependent; zinc ion binding" IPR003347; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Histone lysine demethylase PHF8 (EC 1.14.11.-) (PHD finger protein 8) (zPHF8) phf8 Danio rerio (Zebrafish) (Brachydanio rerio) TR17597_c3_g1_i1 A2A6H3 FBX47_MOUSE 3.00E-13 IPR001810; F-box only protein 47 Fbxo47 Mus musculus (Mouse) TR17597_c4_g1_i1 Q5MNV8 FBX47_HUMAN 3.00E-12 IPR001810; F-box only protein 47 FBXO47 Homo sapiens (Human) TR17599_c0_g1_i1 Q5XII0 EPDR1_RAT 9.00E-11 GO:0005509; GO:0007160; GO:0005576; GO:0005764 calcium ion binding; cell-matrix adhesion; extracellular region; lysosome IPR001299; Mammalian ependymin-related protein 1 (MERP-1) Epdr1 Epdr2 Merp1 Merp2 Rattus norvegicus (Rat) TR17601_c2_g1_i1 Q8TDM0 BCAS4_HUMAN 8.00E-10 GO:0005737 cytoplasm IPR024857; Breast carcinoma-amplified sequence 4 BCAS4 Homo sapiens (Human) TR17601_c2_g2_i1 Q92918 M4K1_HUMAN 1.00E-09 GO:0005524; GO:0008349; GO:0007257; GO:0018105; GO:0005083 P00519; P46108; P46109; P06241; P62993; P16333; P27986; P19174 ATP binding; MAP kinase kinase kinase kinase activity; activation of JUN kinase activity; peptidyl-serine phosphorylation; small GTPase regulator activity IPR001180; IPR011009; IPR021160; IPR000719; IPR017441; IPR002290; Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) MAP4K1 HPK1 Homo sapiens (Human) TR17601_c2_g2_i2 Q86U02 CN165_HUMAN 3.00E-19 GO:0016021 integral to membrane Putative uncharacterized protein encoded by LINC00596 LINC00596 C14orf165 Homo sapiens (Human) TR1761_c0_g2_i1 P13395 SPTCA_DROME 1.00E-55 GO:0005794; GO:0003779; GO:0051693; GO:0016199; GO:0016323; GO:0005509; GO:0007417; GO:0045169; GO:0045478; GO:0030727; GO:0007294; GO:0005811; GO:0042062; GO:0048790; GO:0008017; GO:0007026; GO:0031594; GO:0007274; GO:0007308; GO:0030707; GO:0007009; GO:0008360; GO:0008091; GO:0045170; GO:0030721 Golgi apparatus; actin binding; actin filament capping; axon midline choice point recognition; basolateral plasma membrane; calcium ion binding; central nervous system development; fusome; fusome organization; germarium-derived female germ-line cyst formation; germarium-derived oocyte fate determination; lipid particle; long-term strengthening of neuromuscular junction; maintenance of presynaptic active zone structure; microtubule binding; negative regulation of microtubule depolymerization; neuromuscular junction; neuromuscular synaptic transmission; oocyte construction; ovarian follicle cell development; plasma membrane organization; regulation of cell shape; spectrin; spectrosome; spectrosome organization IPR011992; IPR014837; IPR018247; IPR002048; IPR001452; IPR018159; IPR013315; IPR002017; Spectrin alpha chain alpha-Spec SPEC-A CG1977 Drosophila melanogaster (Fruit fly) TR17611_c0_g1_i1 Q62388 ATM_MOUSE 5.00E-17 GO:0016303; GO:0005524; GO:0003677; GO:0000077; GO:0006975; GO:0006281; GO:0004677; GO:0031572; GO:0007420; GO:0007050; GO:0071480; GO:0000781; GO:0016023; GO:0007507; GO:0071044; GO:0016572; GO:0008630; GO:0042159; GO:0007094; GO:0030889; GO:0051402; GO:0005654; GO:0048599; GO:0018105; GO:0043517; GO:0043525; GO:0002331; GO:0047485; GO:0004674; GO:0090399; GO:0010212; GO:0001756; GO:0005819; GO:0000723 "1-phosphatidylinositol-3-kinase activity; ATP binding; DNA binding; DNA damage checkpoint; DNA damage induced protein phosphorylation; DNA repair; DNA-dependent protein kinase activity; G2 DNA damage checkpoint; brain development; cell cycle arrest; cellular response to gamma radiation; chromosome, telomeric region; cytoplasmic membrane-bounded vesicle; heart development; histone mRNA catabolic process; histone phosphorylation; intrinsic apoptotic signaling pathway in response to DNA damage; lipoprotein catabolic process; mitotic spindle assembly checkpoint; negative regulation of B cell proliferation; neuron apoptotic process; nucleoplasm; oocyte development; peptidyl-serine phosphorylation; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of neuron apoptotic process; pre-B cell allelic exclusion; protein N-terminus binding; protein serine/threonine kinase activity; replicative senescence; response to ionizing radiation; somitogenesis; spindle; telomere maintenance" IPR016024; IPR015519; IPR003152; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR021668; Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T mutated homolog) Atm Mus musculus (Mouse) TR17613_c0_g1_i1 Q7ZWG6 PCFT_DANRE 9.00E-06 GO:0005542; GO:0016021; GO:0055085 folic acid binding; integral to membrane; transmembrane transport IPR011701; IPR016196; Proton-coupled folate transporter (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1) slc46a1 hcp1 pcft zgc:56400 Danio rerio (Zebrafish) (Brachydanio rerio) TR17614_c0_g1_i1 B6ZLK2 CHD1_CHICK 3.00E-36 GO:0005524; GO:0003677; GO:0000775; GO:0004386; GO:0005634; GO:0006355; GO:0006351 "ATP binding; DNA binding; chromosome, centromeric region; helicase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR023780; IPR000953; IPR016197; IPR023779; IPR025260; IPR014001; IPR001650; IPR027417; IPR000330; Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase CHD1) CHD1 Gallus gallus (Chicken) TR17614_c3_g2_i1 Q14839 CHD4_HUMAN 1.00E-09 GO:0005524; GO:0004003; GO:0003677; GO:0016581; GO:0005813; GO:0016568; GO:0005737; GO:0006357; GO:0006351; GO:0008270 Q13547; P01106 "ATP binding; ATP-dependent DNA helicase activity; DNA binding; NuRD complex; centrosome; chromatin modification; cytoplasm; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; zinc ion binding" IPR012957; IPR012958; IPR023780; IPR000953; IPR016197; IPR002464; IPR009462; IPR009463; IPR014001; IPR001650; IPR027417; IPR000330; IPR019786; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) CHD4 Homo sapiens (Human) TR17624_c0_g1_i1 P01130 LDLR_HUMAN 2.00E-25 GO:0005794; GO:0005509; GO:0042632; GO:0070508; GO:0008203; GO:0030669; GO:0005905; GO:0005769; GO:0010008; GO:0009897; GO:0005887; GO:0030299; GO:0005770; GO:0042159; GO:0042157; GO:0034362; GO:0030169; GO:0034383; GO:0005041; GO:0005764; GO:0019048; GO:0015914; GO:0007603; GO:0010867; GO:0010899; GO:0001523; GO:0044281; GO:0030229 Q8NBP7 "Golgi apparatus; calcium ion binding; cholesterol homeostasis; cholesterol import; cholesterol metabolic process; clathrin-coated endocytic vesicle membrane; coated pit; early endosome; endosome membrane; external side of plasma membrane; integral to plasma membrane; intestinal cholesterol absorption; late endosome; lipoprotein catabolic process; lipoprotein metabolic process; low-density lipoprotein particle; low-density lipoprotein particle binding; low-density lipoprotein particle clearance; low-density lipoprotein receptor activity; lysosome; modulation by virus of host morphology or physiology; phospholipid transport; phototransduction, visible light; positive regulation of triglyceride biosynthetic process; regulation of phosphatidylcholine catabolic process; retinoid metabolic process; small molecule metabolic process; very-low-density lipoprotein particle receptor activity" IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor (LDL receptor) LDLR Homo sapiens (Human) TR17625_c1_g1_i1 Q68D10 SPT2_HUMAN 2.00E-11 IPR013256; Protein SPT2 homolog (Protein KU002155) (SPT2 domain-containing protein 1) SPTY2D1 Homo sapiens (Human) TR17626_c2_g1_i1 O60312 AT10A_HUMAN 2.00E-69 GO:0005524; GO:0019829; GO:0005783; GO:0005789; GO:0016021; GO:0034220; GO:0000287; GO:0045332; GO:0004012; GO:0005886; GO:0008360 ATP binding; cation-transporting ATPase activity; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; ion transmembrane transport; magnesium ion binding; phospholipid translocation; phospholipid-translocating ATPase activity; plasma membrane; regulation of cell shape IPR023299; IPR018303; IPR006539; IPR008250; IPR001757; IPR023214; Probable phospholipid-transporting ATPase VA (EC 3.6.3.1) (ATPase class V type 10A) (Aminophospholipid translocase VA) ATP10A ATP10C ATPVA ATPVC KIAA0566 Homo sapiens (Human) TR17627_c0_g1_i1 Q80X90 FLNB_MOUSE 1.00E-09 GO:0030018; GO:0005938; GO:0005737; GO:0005925; GO:0007519; GO:0001725 Z disc; cell cortex; cytoplasm; focal adhesion; skeletal muscle tissue development; stress fiber IPR001589; IPR001715; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-B (FLN-B) (ABP-280-like protein) (Actin-binding-like protein) (Beta-filamin) Flnb Mus musculus (Mouse) TR17630_c2_g1_i1 Q58CW4 NMUR2_BOVIN 3.00E-12 GO:0005525; GO:0043006; GO:0050482; GO:0006816; GO:0007417; GO:0007204; GO:0007625; GO:0048016; GO:0016021; GO:0005229; GO:0042924; GO:0001607; GO:0007200; GO:0005886; GO:0002023; GO:0048265 GTP binding; activation of phospholipase A2 activity by calcium-mediated signaling; arachidonic acid secretion; calcium ion transport; central nervous system development; elevation of cytosolic calcium ion concentration; grooming behavior; inositol phosphate-mediated signaling; integral to membrane; intracellular calcium activated chloride channel activity; neuromedin U binding; neuromedin U receptor activity; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; reduction of food intake in response to dietary excess; response to pain IPR000276; IPR017452; IPR005390; IPR005392; Neuromedin-U receptor 2 (NMU-R2) NMUR2 Bos taurus (Bovine) TR17633_c0_g1_i1 P22105 TENX_HUMAN 1.00E-11 GO:0030036; GO:0007155; GO:0016337; GO:0007160; GO:0030199; GO:0032963; GO:0048251; GO:0043206; GO:0005615; GO:0006631; GO:0008201; GO:0005178; GO:0005622; GO:0005578; GO:0043506; GO:0006641 actin cytoskeleton organization; cell adhesion; cell-cell adhesion; cell-matrix adhesion; collagen fibril organization; collagen metabolic process; elastic fiber assembly; extracellular fibril organization; extracellular space; fatty acid metabolic process; heparin binding; integrin binding; intracellular; proteinaceous extracellular matrix; regulation of JUN kinase activity; triglyceride metabolic process IPR000742; IPR013032; IPR014716; IPR014715; IPR002181; IPR020837; IPR003961; IPR013783; Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) TR17633_c1_g1_i1 Q9HCU4 CELR2_HUMAN 5.00E-07 GO:0004930; GO:0016055; GO:0005509; GO:0033326; GO:0042384; GO:0003341; GO:0005737; GO:0048813; GO:0007156; GO:0016021; GO:0021999; GO:0001764; GO:0007218; GO:0005886; GO:0022407; GO:0032880; GO:0006355; GO:0021591 "G-protein coupled receptor activity; Wnt receptor signaling pathway; calcium ion binding; cerebrospinal fluid secretion; cilium assembly; cilium movement; cytoplasm; dendrite morphogenesis; homophilic cell adhesion; integral to membrane; neural plate anterior/posterior regionalization; neuron migration; neuropeptide signaling pathway; plasma membrane; regulation of cell-cell adhesion; regulation of protein localization; regulation of transcription, DNA-dependent; ventricular system development" IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR001881; IPR013032; IPR000152; IPR002049; IPR017981; IPR001879; IPR000832; IPR000203; IPR009030; IPR001791; IPR001368; Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) CELSR2 CDHF10 EGFL2 KIAA0279 MEGF3 Homo sapiens (Human) TR17634_c0_g1_i1 Q71RI9 KAT3_MOUSE 4.00E-19 GO:0006103; GO:0009058; GO:0047804; GO:0047315; GO:0016212; GO:0005739; GO:0030170 2-oxoglutarate metabolic process; biosynthetic process; cysteine-S-conjugate beta-lyase activity; kynurenine-glyoxylate transaminase activity; kynurenine-oxoglutarate transaminase activity; mitochondrion; pyridoxal phosphate binding IPR004839; IPR015424; IPR015421; IPR015422; Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III) Ccbl2 Kat3 Mus musculus (Mouse) TR17649_c1_g1_i1 Q6ZUK4 TMM26_HUMAN 2.00E-11 GO:0016021 integral to membrane IPR019169; Transmembrane protein 26 TMEM26 Homo sapiens (Human) TR17653_c1_g1_i1 Q8NDA2 HMCN2_HUMAN 3.00E-08 GO:0005509; GO:0005578; GO:0050896 calcium ion binding; proteinaceous extracellular matrix; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 HMCN2 Homo sapiens (Human) TR17653_c1_g2_i1 Q96RW7 HMCN1_HUMAN 3.00E-09 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR17655_c0_g1_i1 Q6NYM1 KLH21_DANRE 7.00E-10 GO:0031463; GO:0051301; GO:0035853; GO:0005737; GO:0007067; GO:0005827; GO:0016567; GO:0032465 Cul3-RING ubiquitin ligase complex; cell division; chromosome passenger complex localization to spindle midzone; cytoplasm; mitosis; polar microtubule; protein ubiquitination; regulation of cytokinesis IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 21 klhl21 zgc:76933 Danio rerio (Zebrafish) (Brachydanio rerio) TR17656_c0_g1_i1 P78527 PRKDC_HUMAN 1.00E-32 GO:0005524; GO:0002326; GO:0003677; GO:0004677; GO:0005958; GO:0033077; GO:0002360; GO:0033153; GO:0006915; GO:0007420; GO:0032869; GO:0005829; GO:0006303; GO:0035234; GO:0007507; GO:0033152; GO:0045087; GO:0005730; GO:0005654; GO:0018105; GO:0043065; GO:0045944; GO:0032481; GO:0002328; GO:0031648; GO:0010332; GO:0001756; GO:0000723; GO:0005667 O43918; P42575; P14921; P50549; P09629; Q9HB75; P17947; P13010; P12956; P25490 ATP binding; B cell lineage commitment; DNA binding; DNA-dependent protein kinase activity; DNA-dependent protein kinase-DNA ligase 4 complex; T cell differentiation in thymus; T cell lineage commitment; T cell receptor V(D)J recombination; apoptotic process; brain development; cellular response to insulin stimulus; cytosol; double-strand break repair via nonhomologous end joining; germ cell programmed cell death; heart development; immunoglobulin V(D)J recombination; innate immune response; nucleolus; nucleoplasm; peptidyl-serine phosphorylation; positive regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of type I interferon production; pro-B cell differentiation; protein destabilization; response to gamma radiation; somitogenesis; telomere maintenance; transcription factor complex IPR011989; IPR016024; IPR003152; IPR011009; IPR012582; IPR000403; IPR018936; IPR003151; IPR014009; DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460) PRKDC HYRC HYRC1 Homo sapiens (Human) TR17664_c0_g1_i1 Q8UWA5 CAH2_TRIHK 6.00E-56 GO:0004089; GO:0005737; GO:0006730; GO:0005886; GO:0008270 carbonate dehydratase activity; cytoplasm; one-carbon metabolic process; plasma membrane; zinc ion binding IPR001148; IPR023561; IPR018338; Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II) ca2 Tribolodon hakonensis (Big-scaled redfin) (Leuciscus hakonensis) TR17667_c1_g1_i1 Q5SQM0 EMAL6_MOUSE 3.00E-30 GO:0005737; GO:0005874 cytoplasm; microtubule IPR005108; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like) Eml6 Eml5l Mus musculus (Mouse) TR17673_c0_g1_i1 P35441 TSP1_MOUSE 2.00E-06 GO:0048266; GO:0048514; GO:0005509; GO:0007155; GO:0003197; GO:0050840; GO:0005615; GO:0003417; GO:0008201; GO:0006954; GO:0016525; GO:0003151; GO:0010811; GO:0010759; GO:0030511; GO:0034976; GO:0016529 behavioral response to pain; blood vessel morphogenesis; calcium ion binding; cell adhesion; endocardial cushion development; extracellular matrix binding; extracellular space; growth plate cartilage development; heparin binding; inflammatory response; negative regulation of angiogenesis; outflow tract morphogenesis; positive regulation of cell-substrate adhesion; positive regulation of macrophage chemotaxis; positive regulation of transforming growth factor beta receptor signaling pathway; response to endoplasmic reticulum stress; sarcoplasmic reticulum IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR001791; IPR000884; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-1 Thbs1 Tsp1 Mus musculus (Mouse) TR17675_c0_g1_i1 Q91ZV7 PLDX1_MOUSE 6.00E-49 GO:0005737; GO:0016021; GO:0007275; GO:0005886; GO:0004872; GO:0005923 P08460 cytoplasm; integral to membrane; multicellular organismal development; plasma membrane; receptor activity; tight junction IPR016201; IPR002165; Plexin domain-containing protein 1 (Tumor endothelial marker 7) Plxdc1 Tem7 Mus musculus (Mouse) TR17676_c0_g1_i1 Q96RY7 IF140_HUMAN 5.00E-53 GO:0042384; GO:0035085; GO:0036064; GO:0030991; GO:0032391 cilium assembly; cilium axoneme; cilium basal body; intraflagellar transport particle A; photoreceptor connecting cilium IPR015943; IPR001680; IPR017986; Intraflagellar transport protein 140 homolog (WD and tetratricopeptide repeats protein 2) IFT140 KIAA0590 WDTC2 Homo sapiens (Human) TR17679_c0_g1_i1 Q8I7P9 POL5_DROME 2.00E-17 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0090305; GO:0005634; GO:0008233; GO:0006508; GO:0006313 "DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus; peptidase activity; proteolysis; transposition, DNA-mediated" IPR001584; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon opus [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR17681_c0_g1_i1 Q7M456 RNOY_CRAGI 2.00E-09 GO:0003723; GO:0005576; GO:0090305; GO:0033897 RNA binding; extracellular region; nucleic acid phosphodiester bond hydrolysis; ribonuclease T2 activity IPR001568; IPR018188; Ribonuclease Oy (RNase Oy) (EC 3.1.27.-) Crassostrea gigas (Pacific oyster) (Crassostrea angulata) TR17693_c2_g1_i1 Q4UMH6 Y381_RICFE 1.00E-06 GO:0015969 guanosine tetraphosphate metabolic process IPR002110; IPR020683; IPR007685; Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR17695_c0_g2_i1 O75592 MYCB2_HUMAN 2.00E-43 GO:0030424; GO:0021785; GO:0021952; GO:0015630; GO:0005634; GO:0051493; GO:0032880; GO:0006355; GO:0006351; GO:0004842; GO:0008270 Q99IB8 "axon; branchiomotor neuron axon guidance; central nervous system projection neuron axonogenesis; microtubule cytoskeleton; nucleus; regulation of cytoskeleton organization; regulation of protein localization; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR004939; IPR017868; IPR008979; IPR027047; IPR013783; IPR014756; IPR012983; IPR009091; IPR000408; IPR003646; IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc) MYCBP2 KIAA0916 PAM Homo sapiens (Human) TR1770_c0_g1_i1 Q9JKK8 ATR_MOUSE 4.00E-42 GO:0005524; GO:0003677; GO:0000077; GO:0006281; GO:0001741; GO:0005654; GO:0004674; GO:0043393 Q8BMG1 ATP binding; DNA binding; DNA damage checkpoint; DNA repair; XY body; nucleoplasm; protein serine/threonine kinase activity; regulation of protein binding IPR011989; IPR016024; IPR003152; IPR021133; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR011990; IPR012993; Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) Atr Kiaa4069 Mus musculus (Mouse) TR17705_c2_g2_i1 P08587 TGM2_CAVCU 9.00E-26 GO:0046872; GO:0018149; GO:0003810; GO:0008483 metal ion binding; peptide cross-linking; protein-glutamine gamma-glutamyltransferase activity; transaminase activity IPR023608; IPR013783; IPR014756; IPR002931; IPR008958; IPR013808; IPR001102; Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Tissue transglutaminase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase-2) (TGase-2) TGM2 Cavia cutleri (Guinea pig) TR17705_c2_g3_i1 Q01841 TGM2_CHICK 4.00E-25 GO:0046872; GO:0018149; GO:0003810 metal ion binding; peptide cross-linking; protein-glutamine gamma-glutamyltransferase activity IPR023608; IPR013783; IPR014756; IPR002931; IPR008958; IPR013808; IPR001102; Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Tissue transglutaminase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase-2) (TGase-2) TGL2 Gallus gallus (Chicken) TR17709_c0_g1_i1 Q80VL1 TDRKH_MOUSE 3.00E-20 GO:0043046; GO:0003723; GO:0030154; GO:0009566; GO:0031047; GO:0007140; GO:0005739; GO:0071546; GO:0071547; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; RNA binding; cell differentiation; fertilization; gene silencing by RNA; male meiosis; mitochondrion; pi-body; piP-body; piRNA metabolic process; spermatogenesis IPR004087; IPR004088; IPR002999; Tudor and KH domain-containing protein (Tudor domain-containing protein 2) Tdrkh Tdrd2 Mus musculus (Mouse) TR17710_c2_g2_i1 A1L1F6 I80DB_DANRE 5.00E-17 GO:0006310; GO:0006281; GO:0005634; GO:0006355; GO:0006351 "DNA recombination; DNA repair; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025927; INO80 complex subunit D-B ino80db zgc:153949 Danio rerio (Zebrafish) (Brachydanio rerio) TR17716_c1_g1_i1 P47844 CBR1_RABIT 3.00E-33 GO:0047021; GO:0004090; GO:0005737; GO:0017144; GO:0050221; GO:0042373 15-hydroxyprostaglandin dehydrogenase (NADP+) activity; carbonyl reductase (NADPH) activity; cytoplasm; drug metabolic process; prostaglandin-E2 9-reductase activity; vitamin K metabolic process IPR002198; IPR002347; IPR016040; IPR020904; Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) CBR1 CBR Oryctolagus cuniculus (Rabbit) TR17720_c6_g1_i1 Q28D01 WDR26_XENTR 4.00E-58 GO:0005737 cytoplasm IPR006595; IPR006594; IPR015943; IPR001680; IPR017986; WD repeat-containing protein 26 wdr26 TGas059a07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR17723_c0_g2_i1 P22770 ACHA7_CHICK 1.00E-09 GO:0042166; GO:0015464; GO:0004889; GO:0005892; GO:0000187; GO:0001540; GO:0006816; GO:0030054; GO:0006874; GO:0017081; GO:0050890; GO:0032720; GO:0045766; GO:0008284; GO:0045211; GO:0042803; GO:0001666; GO:0035094; GO:0015643 acetylcholine binding; acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; activation of MAPK activity; beta-amyloid binding; calcium ion transport; cell junction; cellular calcium ion homeostasis; chloride channel regulator activity; cognition; negative regulation of tumor necrosis factor production; positive regulation of angiogenesis; positive regulation of cell proliferation; postsynaptic membrane; protein homodimerization activity; response to hypoxia; response to nicotine; toxic substance binding IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 Gallus gallus (Chicken) TR17725_c2_g1_i1 Q9UNW1 MINP1_HUMAN 3.00E-26 GO:0003993; GO:0034417; GO:0030282; GO:0005788; GO:0052826; GO:0043647; GO:0008969; GO:0006797 acid phosphatase activity; bisphosphoglycerate 3-phosphatase activity; bone mineralization; endoplasmic reticulum lumen; inositol hexakisphosphate 2-phosphatase activity; inositol phosphate metabolic process; phosphohistidine phosphatase activity; polyphosphate metabolic process IPR000560; IPR016274; "Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80) (Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase) (Ins(1,3,4,5)P(4) 3-phosphatase)" MINPP1 MIPP UNQ900/PRO1917 Homo sapiens (Human) TR17729_c0_g1_i1 E1BD59 TRI56_BOVIN 1.00E-09 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) TR1773_c0_g1_i1 P53035 MIG2_YEAST 1.00E-12 GO:0000978; GO:0001078; GO:0005975; GO:0046872; GO:0005739; GO:0000433; GO:0005634; GO:1900436; GO:0045944 RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; carbohydrate metabolic process; metal ion binding; mitochondrion; negative regulation of transcription from RNA polymerase II promoter by glucose; nucleus; positive regulation of filamentous growth of a population of unicellular organisms in response to starvation; positive regulation of transcription from RNA polymerase II promoter IPR007087; IPR015880; IPR013087; Regulatory protein MIG2 MIG2 MLZ1 YGL209W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR1773_c0_g2_i1 Q8BQN6 OZF_MOUSE 3.00E-31 GO:0003677; GO:0005737; GO:0046872; GO:0005730 DNA binding; cytoplasm; metal ion binding; nucleolus IPR007087; IPR015880; IPR013087; Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146) Znf146 Ozf Zfp146 Mus musculus (Mouse) TR17731_c3_g1_i1 Q9NPD5 SO1B3_HUMAN 7.00E-20 GO:0016323; GO:0015721; GO:0008206; GO:0005737; GO:0005887; GO:0008514; GO:0043252 basolateral plasma membrane; bile acid and bile salt transport; bile acid metabolic process; cytoplasm; integral to plasma membrane; organic anion transmembrane transporter activity; sodium-independent organic anion transport IPR002350; IPR020846; IPR016196; IPR004156; Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8) "SLCO1B3 LST2 OATP1B3 OATP8,SLC21A8" Homo sapiens (Human) TR17731_c4_g1_i1 Q9GMU6 SO1C1_MACFA 2.00E-11 GO:0016021; GO:0006811; GO:0005886; GO:0005215 integral to membrane; ion transport; plasma membrane; transporter activity IPR002350; IPR016196; IPR004156; Solute carrier organic anion transporter family member 1C1 (Solute carrier family 21 member 14) (Thyroxine transporter) SLCO1C1 OATP1C1 SLC21A14 QnpA-13170 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR17740_c4_g2_i1 Q6AXC6 DDX11_MOUSE 3.00E-66 GO:0051539; GO:0005524; GO:0004003; GO:0003677; GO:0008094; GO:0003723; GO:0004386; GO:0046872; GO:0030496; GO:0000790; GO:0005730; GO:0007062; GO:0000922 "4 iron, 4 sulfur cluster binding; ATP binding; ATP-dependent DNA helicase activity; DNA binding; DNA-dependent ATPase activity; RNA binding; helicase activity; metal ion binding; midbody; nuclear chromatin; nucleolus; sister chromatid cohesion; spindle pole" IPR006555; IPR028331; IPR010614; IPR013020; IPR014013; IPR006554; IPR027417; Probable ATP-dependent RNA helicase DDX11 (EC 3.6.4.13) (DEAD/H box protein 11) Ddx11 Mus musculus (Mouse) TR17741_c0_g1_i1 Q80V91 DTX3_MOUSE 5.00E-39 GO:0007219; GO:0005737; GO:0016874; GO:0016567; GO:0008270 Notch signaling pathway; cytoplasm; ligase activity; protein ubiquitination; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase DTX3 (EC 6.3.2.-) (Protein deltex-3) (Deltex3) (mDTX3) Dtx3 Mus musculus (Mouse) TR17741_c1_g2_i1 Q5M7Z0 RNFT1_HUMAN 5.00E-08 GO:0016021; GO:0008270 integral to membrane; zinc ion binding IPR001841; IPR013083; IPR017907; RING finger and transmembrane domain-containing protein 1 (Protein PTD016) RNFT1 PTD016 Homo sapiens (Human) TR17742_c1_g1_i1 Q9R1C6 DGKE_MOUSE 2.00E-59 GO:0005524; GO:0003951; GO:0005737; GO:0004143; GO:0016021; GO:0035556; GO:0046872; GO:0007205 ATP binding; NAD+ kinase activity; cytoplasm; diacylglycerol kinase activity; integral to membrane; intracellular signal transduction; metal ion binding; protein kinase C-activating G-protein coupled receptor signaling pathway IPR016064; IPR000756; IPR001206; IPR002219; Diacylglycerol kinase epsilon (DAG kinase epsilon) (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) Dgke Mus musculus (Mouse) TR17750_c0_g1_i1 P41115 RS11_XENLA 7.00E-81 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR012340; IPR000266; IPR028333; IPR019979; 40S ribosomal protein S11 rps11 Xenopus laevis (African clawed frog) TR17754_c0_g1_i1 Q09225 NRF6_CAEEL 5.00E-18 GO:0016021; GO:0008289; GO:0006869; GO:0007275; GO:0016747 "integral to membrane; lipid binding; lipid transport; multicellular organismal development; transferase activity, transferring acyl groups other than amino-acyl groups" IPR002656; IPR006621; Nose resistant to fluoxetine protein 6 (Protein nrf-6) nrf-6 C08B11.4 Caenorhabditis elegans TR17757_c0_g1_i1 P0CP96 FKBP2_CRYNJ 1.00E-37 GO:0005783; GO:0003755; GO:0006457; GO:0000413 endoplasmic reticulum; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR023566; IPR001179; FK506-binding protein 2 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) FPR2 CNE02370 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR17757_c0_g2_i1 P20080 FKB1A_NEUCR 3.00E-24 GO:0005737; GO:0003755; GO:0006457; GO:0000413 cytoplasm; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR023566; IPR001179; Peptidyl-prolyl cis-trans isomerase fkr-2 (PPIase fkr-2) (EC 5.2.1.8) (FK506-binding protein 1A) (FKBP-1A) fkr-2 fpr-1a 9G6.180 NCU04140 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR17767_c0_g1_i1 Q6XHI1 THIO2_DROYA 3.00E-22 GO:0045454; GO:0006662; GO:0015035 cell redox homeostasis; glycerol ether metabolic process; protein disulfide oxidoreductase activity IPR005746; IPR012336; IPR017937; IPR013766; Thioredoxin-2 (Trx-2) Trx-2 Drosophila yakuba (Fruit fly) TR17771_c4_g1_i1 Q10751 ACE_CHICK 2.00E-66 GO:0004180; GO:0016021; GO:0046872; GO:0008237; GO:0008241; GO:0006508 carboxypeptidase activity; integral to membrane; metal ion binding; metallopeptidase activity; peptidyl-dipeptidase activity; proteolysis IPR001548; Angiotensin-converting enzyme (ACE) (EC 3.2.1.-) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (Fragment) ACE DCP1 Gallus gallus (Chicken) TR17777_c1_g1_i1 O35261 E2F3_MOUSE 3.00E-70 GO:0003677; GO:0007049; GO:0001047; GO:0005634; GO:0008284; GO:0045893; GO:0003700; GO:0005667; GO:0006351 "DNA binding; cell cycle; core promoter binding; nucleus; positive regulation of cell proliferation; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent" IPR015633; IPR003316; IPR011991; Transcription factor E2F3 (E2F-3) E2f3 Mus musculus (Mouse) TR17790_c0_g1_i1 A2VCL2 CC162_HUMAN 2.00E-20 Coiled-coil domain-containing protein 162 (Coiled-coil domain-containing protein 162 pseudogene) CCDC162P C6orf184 C6orf185 CCDC162 Homo sapiens (Human) TR17795_c1_g1_i1 P10039 TENA_CHICK 3.00E-21 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) TNC Gallus gallus (Chicken) TR17804_c0_g1_i1 O42993 FKBP_SCHPO 1.00E-46 GO:0000747; GO:0005829; GO:0005634; GO:0003755; GO:0006457; GO:0000413 conjugation with cellular fusion; cytosol; nucleus; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR023566; IPR001179; Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (FK506-binding protein) (FKBP) fkh1 SPBC24E9.17c SPBC839.17c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR1781_c0_g1_i1 Q28615 S13A2_RABIT 9.00E-37 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR001898; Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter) SLC13A2 NADC1 SDCT1 Oryctolagus cuniculus (Rabbit) TR17815_c0_g1_i1 Q9KX40 ESTB_BURGA 6.00E-14 GO:0005737; GO:0016787 cytoplasm; hydrolase activity IPR001466; IPR012338; IPR023650; Esterase EstB (EC 3.1.1.-) estB Burkholderia gladioli (Pseudomonas marginata) (Phytomonas marginata) TR17823_c0_g1_i1 P04461 MYH7_RABIT 9.00E-46 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR001609; IPR002928; IPR027417; "Myosin-7 (Beta isomyosin) (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) (Fragment)" MYH7 Oryctolagus cuniculus (Rabbit) TR17823_c2_g1_i1 P24733 MYS_AEQIR 9.00E-82 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR015650; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, striated muscle" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR17837_c0_g1_i1 O08680 EPHA3_RAT 2.00E-17 GO:0005524; GO:0005004; GO:0016477; GO:0005769; GO:0097156; GO:0097155; GO:0001660; GO:0005887; GO:0032319; GO:0032956; GO:0010717; GO:0051893; GO:0070507; GO:0034097; GO:0032496 ATP binding; GPI-linked ephrin receptor activity; cell migration; early endosome; fasciculation of motor neuron axon; fasciculation of sensory neuron axon; fever generation; integral to plasma membrane; regulation of Rho GTPase activity; regulation of actin cytoskeleton organization; regulation of epithelial to mesenchymal transition; regulation of focal adhesion assembly; regulation of microtubule cytoskeleton organization; response to cytokine stimulus; response to lipopolysaccharide IPR027936; IPR001090; IPR003961; IPR008979; IPR009030; IPR013783; IPR011009; IPR000719; IPR017441; IPR001660; IPR013761; IPR011510; IPR001245; IPR011641; IPR008266; IPR020635; IPR016257; IPR001426; Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (rEK4) (Tyrosine-protein kinase TYRO4) Epha3 Rek4 Tyro4 Rattus norvegicus (Rat) TR17837_c0_g2_i1 P00530 FPS_FUJSV 4.00E-18 GO:0005524; GO:0004715 ATP binding; non-membrane spanning protein tyrosine kinase activity IPR001060; IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR008266; IPR020635; IPR016250; Tyrosine-protein kinase transforming protein Fps (EC 2.7.10.2) V-FPS Fujinami sarcoma virus TR17837_c4_g1_i1 Q93105 INSR_AEDAE 3.00E-15 GO:0005524; GO:0051425; GO:0042169; GO:0043559; GO:0043560; GO:0005009; GO:0016021; GO:0046872; GO:0043548; GO:0046777; GO:0051290 ATP binding; PTB domain binding; SH2 domain binding; insulin binding; insulin receptor substrate binding; insulin-activated receptor activity; integral to membrane; metal ion binding; phosphatidylinositol 3-kinase binding; protein autophosphorylation; protein heterotetramerization IPR000494; IPR003961; IPR006211; IPR006212; IPR009030; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR016246; IPR002011; Insulin-like receptor (MIR) (EC 2.7.10.1) [Cleaved into: Insulin-like receptor alpha chain; Insulin-like receptor beta chain] InR AAEL002317 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR17843_c0_g1_i1 G3UZ78 ADGB_MOUSE 5.00E-06 GO:0004198; GO:0020037; GO:0005622; GO:0005506; GO:0019825; GO:0015671; GO:0006508 calcium-dependent cysteine-type endopeptidase activity; heme binding; intracellular; iron ion binding; oxygen binding; oxygen transport; proteolysis IPR012292; IPR000048; IPR001300; Androglobin (Calpain-7-like protein) Adgb Capn7l Mus musculus (Mouse) TR17851_c0_g1_i2 Q6NW29 RWDD4_HUMAN 2.00E-40 IPR006575; IPR016135; RWD domain-containing protein 4 (Protein FAM28A) RWDD4 FAM28A RWDD4A Homo sapiens (Human) TR17853_c6_g1_i1 Q6P158 DHX57_HUMAN 2.00E-16 GO:0005524; GO:0008026; GO:0046872; GO:0003676 ATP binding; ATP-dependent helicase activity; metal ion binding; nucleic acid binding IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; IPR006575; IPR009060; IPR015940; IPR000571; Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57) DHX57 Homo sapiens (Human) TR17858_c0_g1_i1 P86810 OXLA_SIGCA 3.00E-06 GO:0001716; GO:0042742; GO:0005576; GO:0045087 L-amino-acid oxidase activity; defense response to bacterium; extracellular region; innate immune response IPR002937; IPR001613; L-amino-acid oxidase (EC 1.4.3.2) (Antiparasitic protein) (APP) (Serum L-amino-acid oxidase) (SR-LAAO) Siganus canaliculatus (White-spotted spinefoot) (Chaetodon canaliculatus) TR17860_c0_g1_i1 Q94900 GLUCL_DROME 2.00E-33 GO:0030054; GO:0034707; GO:0008068; GO:0016021; GO:0048812; GO:0005886; GO:0045211 cell junction; chloride channel complex; extracellular-glutamate-gated chloride channel activity; integral to membrane; neuron projection morphogenesis; plasma membrane; postsynaptic membrane IPR006028; IPR006202; IPR006201; IPR006029; IPR018000; Glutamate-gated chloride channel (DrosGluCl) GluClalpha GluCl CG7535 Drosophila melanogaster (Fruit fly) TR17860_c1_g1_i1 P22933 GBRD_MOUSE 2.00E-23 GO:0004890; GO:0030054; GO:0005254; GO:0034707; GO:0005230; GO:0045211; GO:0007268 GABA-A receptor activity; cell junction; chloride channel activity; chloride channel complex; extracellular ligand-gated ion channel activity; postsynaptic membrane; synaptic transmission IPR006028; IPR008098; IPR006202; IPR006201; IPR006029; IPR018000; Gamma-aminobutyric acid receptor subunit delta (GABA(A) receptor subunit delta) Gabrd Mus musculus (Mouse) TR17865_c1_g2_i1 Q96M20 CT152_HUMAN 7.00E-06 IPR018490; IPR018488; IPR000595; IPR014710; Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) TR17869_c4_g1_i1 Q3SYG4 PTHB1_HUMAN 8.00E-78 GO:0034464; GO:0060170; GO:0005737; GO:0045444; GO:0005815; GO:0005634; GO:0005886; GO:0050896; GO:0007601 Q8NFJ9; Q8TAM1; Q6ZW61; Q9BXC9; Q8N3I7; Q9NQ48; Q8TAM2 BBSome; cilium membrane; cytoplasm; fat cell differentiation; microtubule organizing center; nucleus; plasma membrane; response to stimulus; visual perception IPR028074; IPR028073; IPR026511; Protein PTHB1 (Bardet-Biedl syndrome 9 protein) (Parathyroid hormone-responsive B1 gene protein) BBS9 PTHB1 Homo sapiens (Human) TR17877_c1_g1_i1 Q0VG85 CC162_MOUSE 1.00E-11 Coiled-coil domain-containing protein 162 (Protein CCDC162P) Ccdc162p Ccdc162 Mus musculus (Mouse) TR17884_c0_g2_i1 A5V8T0 PROA_SPHWW 2.00E-27 GO:0055129; GO:0050661; GO:0005737; GO:0004350 L-proline biosynthetic process; NADP binding; cytoplasm; glutamate-5-semialdehyde dehydrogenase activity IPR016161; IPR016163; IPR016162; IPR015590; IPR000965; IPR020593; IPR012134; Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase) (GSA dehydrogenase) proA Swit_2337 Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273) TR17884_c1_g1_i1 P54886 P5CS_HUMAN 6.00E-68 GO:0005524; GO:0055129; GO:0034641; GO:0019240; GO:0004349; GO:0006536; GO:0004350; GO:0005743; GO:0006592; GO:0006561 ATP binding; L-proline biosynthetic process; cellular nitrogen compound metabolic process; citrulline biosynthetic process; glutamate 5-kinase activity; glutamate metabolic process; glutamate-5-semialdehyde dehydrogenase activity; mitochondrial inner membrane; ornithine biosynthetic process; proline biosynthetic process IPR016161; IPR016163; IPR016162; IPR015590; IPR001048; IPR000965; IPR020593; IPR001057; IPR019797; IPR005766; Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] ALDH18A1 GSAS P5CS PYCS Homo sapiens (Human) TR1789_c0_g1_i1 Q91605 HTF4_XENLA 5.00E-20 GO:0070888; GO:0005634; GO:0045666; GO:0046982; GO:0006355; GO:0006351 "E-box binding; nucleus; positive regulation of neuron differentiation; protein heterodimerization activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011598; Transcription factor XE1.1 (Fragment) Xenopus laevis (African clawed frog) TR17890_c0_g1_i1 Q6ZS30 NBEL1_HUMAN 2.00E-14 IPR016024; IPR000409; IPR008985; IPR026916; IPR023362; IPR015943; IPR001680; IPR017986; Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) NBEAL1 ALS2CR16 ALS2CR17 Homo sapiens (Human) TR17890_c0_g2_i1 E7FAW3 NBEL2_DANRE 6.00E-12 GO:0005783 endoplasmic reticulum IPR011989; IPR016024; IPR000409; IPR008985; IPR026916; IPR023362; IPR015943; IPR001680; IPR017986; Neurobeachin-like protein 2 nbeal2 Danio rerio (Zebrafish) (Brachydanio rerio) TR17895_c0_g1_i1 A8QMS7 MYD88_TAKRU 9.00E-07 GO:0002755; GO:0005737; GO:0006954; GO:0045087; GO:0043123 MyD88-dependent toll-like receptor signaling pathway; cytoplasm; inflammatory response; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade IPR011029; IPR000488; IPR017281; IPR000157; Myeloid differentiation primary response protein MyD88 myd88 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR17897_c1_g1_i1 Q5RC90 NCS1_PONAB 1.00E-64 GO:0032580; GO:0005509; GO:0030054; GO:0048471; GO:0014069; GO:0045211; GO:0010975; GO:0005245 Golgi cisterna membrane; calcium ion binding; cell junction; perinuclear region of cytoplasm; postsynaptic density; postsynaptic membrane; regulation of neuron projection development; voltage-gated calcium channel activity IPR011992; IPR018247; IPR002048; IPR001125; Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) NCS1 FREQ Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR17902_c1_g1_i1 Q28811 PHR_POTTR 7.00E-69 GO:0003677; GO:0006281; GO:0003904; GO:0018298 DNA binding; DNA repair; deoxyribodipyrimidine photo-lyase activity; protein-chromophore linkage IPR008148; IPR006050; IPR005101; IPR014729; Deoxyribodipyrimidine photo-lyase (EC 4.1.99.3) (DNA photolyase) (Photoreactivating enzyme) PHR Potorous tridactylus (Potoroo) TR17903_c0_g1_i1 Q6TAW2 SERP2_MOUSE 1.00E-16 GO:0005789; GO:0016021; GO:0015031 endoplasmic reticulum membrane; integral to membrane; protein transport IPR010580; Stress-associated endoplasmic reticulum protein 2 (Ribosome-associated membrane protein RAMP4-2) Serp2 Mus musculus (Mouse) TR17904_c0_g1_i1 P54145 AMT1_CAEEL 4.00E-22 GO:0008519; GO:0016021 ammonium transmembrane transporter activity; integral to membrane IPR001905; IPR018047; IPR024041; Putative ammonium transporter 1 amt-1 C05E11.4 Caenorhabditis elegans TR17908_c4_g1_i1 Q7TN88 PK1L2_MOUSE 2.00E-13 GO:0005262; GO:0005509; GO:0030246; GO:0050982; GO:0016021; GO:0016020; GO:0007218 calcium channel activity; calcium ion binding; carbohydrate binding; detection of mechanical stimulus; integral to membrane; membrane; neuropeptide signaling pathway IPR001304; IPR016186; IPR016187; IPR000203; IPR000922; IPR008976; IPR022409; IPR002859; IPR013122; IPR003915; IPR000601; IPR001024; IPR014010; Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) Pkd1l2 Mus musculus (Mouse) TR17909_c2_g1_i1 Q9BQT8 ODC_HUMAN 7.00E-35 GO:0034641; GO:0016021; GO:0006554; GO:0005743; GO:0055085 cellular nitrogen compound metabolic process; integral to membrane; lysine catabolic process; mitochondrial inner membrane; transmembrane transport IPR002067; IPR018108; IPR023395; Mitochondrial 2-oxodicarboxylate carrier (Solute carrier family 25 member 21) SLC25A21 ODC Homo sapiens (Human) TR17917_c0_g1_i1 O77775 NCF2_BOVIN 4.00E-28 GO:0005737 cytoplasm IPR000270; IPR000108; IPR001452; IPR013026; IPR011990; IPR001440; IPR013105; IPR019734; Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (Neutrophil NADPH oxidase factor 2) (p67-phox) NCF2 Bos taurus (Bovine) TR17920_c0_g1_i1 Q12800 TFCP2_HUMAN 2.00E-17 GO:0003677; GO:0005634; GO:0006357; GO:0003700; GO:0006351 "DNA binding; nucleus; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007604; IPR013761; Alpha-globin transcription factor CP2 (SAA3 enhancer factor) (Transcription factor LSF) TFCP2 LSF SEF Homo sapiens (Human) TR17920_c2_g1_i1 Q3UNW5 TF2L1_MOUSE 3.00E-68 GO:0003677; GO:0000902; GO:0005737; GO:0007028; GO:0008340; GO:0002070; GO:0016020; GO:0005739; GO:0000122; GO:0005730; GO:0005634; GO:0045927; GO:0007431; GO:0005667; GO:0006351 Q61539 "DNA binding; cell morphogenesis; cytoplasm; cytoplasm organization; determination of adult lifespan; epithelial cell maturation; membrane; mitochondrion; negative regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; positive regulation of growth; salivary gland development; transcription factor complex; transcription, DNA-dependent" IPR007604; IPR013761; Transcription factor CP2-like protein 1 (CP2-related transcriptional repressor 1) (CRTR-1) Tfcp2l1 Crtr1 Tcfcp2l1 Mus musculus (Mouse) TR1793_c0_g1_i1 Q29488 CP2DH_MACFA 2.00E-19 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; IPR008069; Cytochrome P450 2D17 (EC 1.14.14.1) (CYPIID17) CYP2D17 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR17933_c0_g1_i1 Q3TLP5 ECHD2_MOUSE 8.00E-10 GO:0006631; GO:0016829; GO:0005739 fatty acid metabolic process; lyase activity; mitochondrion IPR014748; IPR001753; IPR018376; "Enoyl-CoA hydratase domain-containing protein 2, mitochondrial" Echdc2 D4Ertd765e Mus musculus (Mouse) TR17936_c0_g1_i1 P50898 MIG1_KLULA 1.00E-11 GO:0003677; GO:0005975; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; carbohydrate metabolic process; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Regulatory protein MIG1 MIG1 KLLA0E10989g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR17936_c0_g2_i1 P08155 KRUH_DROME 1.00E-12 GO:0003677; GO:0046872; GO:0007552; GO:0045316; GO:0035075 DNA binding; metal ion binding; metamorphosis; negative regulation of compound eye photoreceptor development; response to ecdysone IPR007087; IPR015880; IPR013087; Krueppel homologous protein 1 Kr-h1 Kr-h CG9167 Drosophila melanogaster (Fruit fly) TR17954_c0_g2_i1 Q95JQ1 SPT22_MACFA 5.00E-10 Spermatogenesis-associated protein 22 SPATA22 QnpA-20808 QtsA-14618 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR17955_c0_g2_i1 Q75K27 RS24_DICDI 1.00E-25 GO:0022627; GO:0000462; GO:0005730; GO:0000166; GO:0003735; GO:0006414 "cytosolic small ribosomal subunit; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleolus; nucleotide binding; structural constituent of ribosome; translational elongation" IPR012677; IPR012678; IPR001976; IPR018098; 40S ribosomal protein S24 rps24 DDB_G0275473 Dictyostelium discoideum (Slime mold) TR17955_c0_g3_i1 Q9W6X9 RS24_ORYLA 7.00E-40 GO:0000166; GO:0005840; GO:0003735; GO:0006412 nucleotide binding; ribosome; structural constituent of ribosome; translation IPR012677; IPR012678; IPR001976; IPR018098; 40S ribosomal protein S24 rps24 Oryzias latipes (Medaka fish) (Japanese ricefish) TR17955_c0_g4_i1 Q9W6X9 RS24_ORYLA 2.00E-30 GO:0000166; GO:0005840; GO:0003735; GO:0006412 nucleotide binding; ribosome; structural constituent of ribosome; translation IPR012677; IPR012678; IPR001976; IPR018098; 40S ribosomal protein S24 rps24 Oryzias latipes (Medaka fish) (Japanese ricefish) TR17959_c1_g1_i1 P82909 RT36_HUMAN 1.00E-10 GO:0005763; GO:0003735; GO:0006412 mitochondrial small ribosomal subunit; structural constituent of ribosome; translation "28S ribosomal protein S36, mitochondrial (MRP-S36) (S36mt)" MRPS36 DC47 Homo sapiens (Human) TR17963_c0_g1_i1 Q6ZVD8 PHLP2_HUMAN 4.00E-08 GO:0038095; GO:0005829; GO:0007173; GO:0008543; GO:0045087; GO:0046872; GO:0048011; GO:0005634; GO:0048015; GO:0001917; GO:0042622; GO:0006470; GO:0004722 Fc-epsilon receptor signaling pathway; cytosol; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; metal ion binding; neurotrophin TRK receptor signaling pathway; nucleus; phosphatidylinositol-mediated signaling; photoreceptor inner segment; photoreceptor outer segment membrane; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001611; IPR003591; IPR001932; PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like) PHLPP2 KIAA0931 PHLPPL Homo sapiens (Human) TR17966_c0_g1_i1 Q8TAT5 NEIL3_HUMAN 1.00E-13 GO:0019104; GO:0003906; GO:0006284; GO:0000405; GO:0003684; GO:0003690; GO:0006289; GO:0005634; GO:0003697; GO:0008270 DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; base-excision repair; bubble DNA binding; damaged DNA binding; double-stranded DNA binding; nucleotide-excision repair; nucleus; single-stranded DNA binding; zinc ion binding IPR015886; IPR015887; IPR012319; IPR010979; IPR000214; IPR010666; IPR001876; Endonuclease 8-like 3 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase FPG2) (DNA glycosylase/AP lyase Neil3) (Endonuclease VIII-like 3) (Nei-like protein 3) NEIL3 Homo sapiens (Human) TR17966_c0_g2_i1 Q6ZU11 YD002_HUMAN 6.00E-06 TR17967_c0_g1_i1 Q8C5V5 WDR27_MOUSE 4.00E-14 IPR011047; IPR015943; IPR001680; IPR017986; WD repeat-containing protein 27 Wdr27 Mus musculus (Mouse) TR17969_c0_g1_i1 P29240 5NTD_DISOM 2.00E-12 GO:0008253; GO:0031225; GO:0046872; GO:0000166; GO:0009166; GO:0005886 5'-nucleotidase activity; anchored to membrane; metal ion binding; nucleotide binding; nucleotide catabolic process; plasma membrane IPR008334; IPR006146; IPR006179; IPR004843; 5'-nucleotidase (EC 3.1.3.5) (Ecto-nucleotidase) Diplobatis ommata (Ocellated electric ray) (Discopyge ommata) TR17970_c1_g1_i1 Q5T6R2 TPT2L_HUMAN 4.00E-07 IPR000008; IPR014020; "Putative phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2P1" TPTE2P1 Homo sapiens (Human) TR17970_c1_g1_i2 Q6XPS3 TPTE2_HUMAN 4.00E-46 GO:0000139; GO:0005789; GO:0016021; GO:0005216; GO:0035335; GO:0006661; GO:0016314; GO:0004725; GO:0008138; GO:0044281 "Golgi membrane; endoplasmic reticulum membrane; integral to membrane; ion channel activity; peptidyl-tyrosine dephosphorylation; phosphatidylinositol biosynthetic process; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; small molecule metabolic process" IPR000008; IPR000340; IPR005821; IPR014019; IPR014020; IPR016130; "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (Lipid phosphatase TPIP) (TPTE and PTEN homologous inositol lipid phosphatase)" TPTE2 TPIP Homo sapiens (Human) TR17977_c0_g2_i2 P41208 CETN2_HUMAN 2.00E-46 GO:0005524; GO:0008026; GO:0000086; GO:0071942; GO:0005509; GO:0051301; GO:0005814; GO:0007099; GO:0005829; GO:0005932; GO:0007067; GO:0003676; GO:0006289; GO:0032391; GO:0032465; GO:0007283 O43303; A8K8P3; Q01831 ATP binding; ATP-dependent helicase activity; G2/M transition of mitotic cell cycle; XPC complex; calcium ion binding; cell division; centriole; centriole replication; cytosol; microtubule basal body; mitosis; nucleic acid binding; nucleotide-excision repair; photoreceptor connecting cilium; regulation of cytokinesis; spermatogenesis IPR011992; IPR018247; IPR002048; IPR000629; Centrin-2 (Caltractin isoform 1) CETN2 CALT CEN2 Homo sapiens (Human) TR17986_c1_g1_i1 P50170 RDH2_RAT 9.00E-27 GO:0005783; GO:0042573; GO:0004745; GO:0042572 endoplasmic reticulum; retinoic acid metabolic process; retinol dehydrogenase activity; retinol metabolic process IPR002198; IPR002347; IPR016040; IPR020904; Cofactor metabolism; retinol metabolism. Retinol dehydrogenase 2 (EC 1.1.1.105) (29 kDa protein) (Retinol dehydrogenase type II) (RODH II) Rdh2 Rodhii Rattus norvegicus (Rat) TR1799_c0_g1_i1 Q9D855 QCR7_MOUSE 1.00E-35 GO:0006122; GO:0005743; GO:0005750 "mitochondrial electron transport, ubiquinol to cytochrome c; mitochondrial inner membrane; mitochondrial respiratory chain complex III" IPR003197; Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) Uqcrb Mus musculus (Mouse) TR17991_c1_g1_i1 Q9MZK9 KLRD1_MACMU 9.00E-09 GO:0030246; GO:0016021 carbohydrate binding; integral to membrane IPR001304; IPR016186; IPR016187; Natural killer cells antigen CD94 (Killer cell lectin-like receptor subfamily D member 1) (NK cell receptor) (CD antigen CD94) KLRD1 CD94 Macaca mulatta (Rhesus macaque) TR17993_c0_g1_i1 Q9ULC3 RAB23_HUMAN 2.00E-90 GO:0005525; GO:0003924; GO:0005776; GO:0000045; GO:0006968; GO:0097094; GO:0042733; GO:0010008; GO:0045861; GO:0042992; GO:0045335; GO:0030670; GO:0005886; GO:0015031; GO:0008589; GO:0007264; GO:0021513 GTP binding; GTPase activity; autophagic vacuole; autophagic vacuole assembly; cellular defense response; craniofacial suture morphogenesis; embryonic digit morphogenesis; endosome membrane; negative regulation of proteolysis; negative regulation of transcription factor import into nucleus; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane; protein transport; regulation of smoothened signaling pathway; small GTPase mediated signal transduction; spinal cord dorsal/ventral patterning IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-23 RAB23 HSPC137 Homo sapiens (Human) TR17995_c0_g1_i1 A7MB89 FEM1C_BOVIN 3.00E-13 GO:0005737; GO:0016567 cytoplasm; protein ubiquitination IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog C (FEM1c) (FEM1-gamma) FEM1C Bos taurus (Bovine) TR17997_c0_g1_i1 Q14112 NID2_HUMAN 2.00E-15 GO:0005604; GO:0005509; GO:0007155; GO:0009986; GO:0007160; GO:0005518 basement membrane; calcium ion binding; cell adhesion; cell surface; cell-matrix adhesion; collagen binding IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR006605; IPR009017; IPR023413; IPR009030; IPR000033; IPR003886; IPR000716; Nidogen-2 (NID-2) (Osteonidogen) NID2 Homo sapiens (Human) TR17997_c1_g1_i1 P22105 TENX_HUMAN 3.00E-16 GO:0030036; GO:0007155; GO:0016337; GO:0007160; GO:0030199; GO:0032963; GO:0048251; GO:0043206; GO:0005615; GO:0006631; GO:0008201; GO:0005178; GO:0005622; GO:0005578; GO:0043506; GO:0006641 actin cytoskeleton organization; cell adhesion; cell-cell adhesion; cell-matrix adhesion; collagen fibril organization; collagen metabolic process; elastic fiber assembly; extracellular fibril organization; extracellular space; fatty acid metabolic process; heparin binding; integrin binding; intracellular; proteinaceous extracellular matrix; regulation of JUN kinase activity; triglyceride metabolic process IPR000742; IPR013032; IPR014716; IPR014715; IPR002181; IPR020837; IPR003961; IPR013783; Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) TR18003_c1_g1_i1 P84770 IRS1B_XENLA 1.00E-19 GO:0042169; GO:0005737; GO:0005158; GO:0008286; GO:0005159; GO:0048009; GO:0005634; GO:0043548; GO:0005543; GO:0004871 SH2 domain binding; cytoplasm; insulin receptor binding; insulin receptor signaling pathway; insulin-like growth factor receptor binding; insulin-like growth factor receptor signaling pathway; nucleus; phosphatidylinositol 3-kinase binding; phospholipid binding; signal transducer activity IPR002404; IPR011993; IPR001849; Insulin receptor substrate 1-B (IRS1-B) (xIRS-1-B) (XIRS-L') irs1-b Xenopus laevis (African clawed frog) TR18013_c0_g2_i1 Q80T91 MEG11_MOUSE 3.00E-53 GO:0016323; GO:0034109; GO:0016021; GO:0010842 basolateral plasma membrane; homotypic cell-cell adhesion; integral to membrane; retina layer formation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) TR18014_c1_g1_i1 Q96FN5 KIF12_HUMAN 7.00E-52 GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0007018 ATP binding; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF12 KIF12 Homo sapiens (Human) TR18014_c1_g4_i1 Q80TF6 STAR9_MOUSE 1.00E-15 GO:0005524; GO:0005814; GO:0008289; GO:0008017; GO:0003777; GO:0007018; GO:0005634; GO:0051225 ATP binding; centriole; lipid binding; microtubule binding; microtubule motor activity; microtubule-based movement; nucleus; spindle assembly IPR000253; IPR019821; IPR001752; IPR027417; IPR008984; IPR023393; IPR002913; StAR-related lipid transfer protein 9 (Kinesin-like protein Kif16a) (START domain-containing protein 9) (StARD9) Stard9 Kiaa1300 Kif16a Mus musculus (Mouse) TR18022_c0_g1_i1 O95407 TNF6B_HUMAN 4.00E-14 GO:0006915; GO:0005615; GO:0043066; GO:0004872 O43557 apoptotic process; extracellular space; negative regulation of apoptotic process; receptor activity IPR001368; Tumor necrosis factor receptor superfamily member 6B (Decoy receptor 3) (DcR3) (Decoy receptor for Fas ligand) (M68) TNFRSF6B DCR3 TR6 UNQ186/PRO212 Homo sapiens (Human) TR18026_c0_g1_i1 Q32P84 CK010_BOVIN 4.00E-39 GO:0016021 integral to membrane IPR007915; Transmembrane protein 258 TMEM258 Bos taurus (Bovine) TR18027_c3_g1_i1 Q24157 BRN_DROME 4.00E-10 GO:0000139; GO:0005795; GO:0007219; GO:0046981; GO:0007298; GO:0005576; GO:0047915; GO:0007293; GO:0006688; GO:0008314; GO:0016021; GO:0042248; GO:0001744; GO:0007299; GO:0006486 "Golgi membrane; Golgi stack; Notch signaling pathway; beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity; border follicle cell migration; extracellular region; ganglioside galactosyltransferase activity; germarium-derived egg chamber formation; glycosphingolipid biosynthetic process; gurken receptor signaling pathway; integral to membrane; maintenance of polarity of follicular epithelium; optic lobe placode formation; ovarian follicle cell-cell adhesion; protein glycosylation" IPR002659; "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) TR18030_c0_g1_i1 Q86UD7 TBC26_HUMAN 5.00E-08 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; TBC1 domain family member 26 TBC1D26 Homo sapiens (Human) TR18030_c1_g1_i1 Q92738 US6NL_HUMAN 4.00E-64 GO:0005794; GO:0007030; GO:0005097; GO:0016023; GO:0031410; GO:0035526 "Golgi apparatus; Golgi organization; Rab GTPase activator activity; cytoplasmic membrane-bounded vesicle; cytoplasmic vesicle; retrograde transport, plasma membrane to Golgi" IPR000195; USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) USP6NL KIAA0019 Homo sapiens (Human) TR18030_c1_g2_i1 Q92738 US6NL_HUMAN 3.00E-81 GO:0005794; GO:0007030; GO:0005097; GO:0016023; GO:0031410; GO:0035526 "Golgi apparatus; Golgi organization; Rab GTPase activator activity; cytoplasmic membrane-bounded vesicle; cytoplasmic vesicle; retrograde transport, plasma membrane to Golgi" IPR000195; USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) USP6NL KIAA0019 Homo sapiens (Human) TR18035_c2_g2_i1 Q9NBX4 RTXE_DROME 2.00E-07 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR18039_c2_g1_i1 Q1RMR4 RAB15_BOVIN 6.00E-48 GO:0005525; GO:0005886; GO:0015031; GO:0007264 GTP binding; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-15 RAB15 Bos taurus (Bovine) TR18042_c0_g1_i1 P0C6R2 ARMC2_BOVIN 1.00E-15 IPR011989; IPR016024; IPR000225; Armadillo repeat-containing protein 2 ARMC2 Bos taurus (Bovine) TR18055_c0_g1_i1 O14815 CAN9_HUMAN 6.00E-06 GO:0005509; GO:0004198; GO:0007586; GO:0005622; GO:0006508 calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; digestion; intracellular; proteolysis IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-9 (EC 3.4.22.-) (Digestive tract-specific calpain) (New calpain 4) (nCL-4) (Protein CG36) CAPN9 NCL4 Homo sapiens (Human) TR18058_c2_g1_i1 P08955 PYR1_MESAU 2.00E-90 GO:0044205; GO:0006207; GO:0005524; GO:0002134; GO:0070335; GO:0004070; GO:0070409; GO:0004088; GO:0005829; GO:0004151; GO:0006543; GO:0006541; GO:0046872; GO:0005739; GO:0016363; GO:0018107; GO:0046777; GO:0004672 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; ATP binding; UTP binding; aspartate binding; aspartate carbamoyltransferase activity; carbamoyl phosphate biosynthetic process; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; cytosol; dihydroorotase activity; glutamine catabolic process; glutamine metabolic process; metal ion binding; mitochondrion; nuclear matrix; peptidyl-threonine phosphorylation; protein autophosphorylation; protein kinase activity IPR006132; IPR006130; IPR002082; IPR006131; IPR011761; IPR013815; IPR013816; IPR006275; IPR005481; IPR005480; IPR006274; IPR002474; IPR005479; IPR005483; IPR002195; IPR017926; IPR011059; IPR011607; IPR016185; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] CAD Mesocricetus auratus (Golden hamster) TR18060_c4_g1_i1 Q3TDN0 DISP1_MOUSE 1.00E-14 GO:0007368; GO:0060539; GO:0009953; GO:0009880; GO:0008158; GO:0016021; GO:0007225; GO:0015197; GO:0007224 determination of left/right symmetry; diaphragm development; dorsal/ventral pattern formation; embryonic pattern specification; hedgehog receptor activity; integral to membrane; patched ligand maturation; peptide transporter activity; smoothened signaling pathway IPR003392; IPR000731; Protein dispatched homolog 1 (Mdispa) Disp1 Disp Dispa Icb Icbins Mus musculus (Mouse) TR18061_c1_g1_i1 O08564 LPP1_RAT 5.00E-23 GO:0016021; GO:0016020; GO:0008195; GO:0005886 integral to membrane; membrane; phosphatidate phosphatase activity; plasma membrane IPR000326; Lipid phosphate phosphohydrolase 1 (EC 3.1.3.4) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a) Ppap2a Lpp1 Rattus norvegicus (Rat) TR18061_c1_g2_i1 Q9V576 WUN_DROME 2.00E-26 GO:0045177; GO:0050829; GO:0009880; GO:0035234; GO:0035233; GO:0016021; GO:0045824; GO:0007424; GO:0008195; GO:0007280; GO:0042803; GO:0005918; GO:0019991 apical part of cell; defense response to Gram-negative bacterium; embryonic pattern specification; germ cell programmed cell death; germ cell repulsion; integral to membrane; negative regulation of innate immune response; open tracheal system development; phosphatidate phosphatase activity; pole cell migration; protein homodimerization activity; septate junction; septate junction assembly IPR000326; Putative phosphatidate phosphatase (EC 3.1.3.4) (Germ cell guidance factor) (Phosphatidic acid phosphatase type 2) (Protein wunen) wun CG8804 Drosophila melanogaster (Fruit fly) TR18061_c2_g1_i1 P97544 LPP3_RAT 3.00E-24 GO:0005789; GO:0016021; GO:0008152; GO:0008195 endoplasmic reticulum membrane; integral to membrane; metabolic process; phosphatidate phosphatase activity IPR000326; Lipid phosphate phosphohydrolase 3 (EC 3.1.3.4) (Differentially expressed in rat intestine 42) (Dri42) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) Ppap2b Lpp3 Rattus norvegicus (Rat) TR18066_c0_g1_i1 Q9VQ62 NPC2_DROME 5.00E-21 GO:0045456; GO:0005615; GO:0030882; GO:0001530; GO:0070891; GO:0042834; GO:0061057; GO:0055092; GO:0015918; GO:0008039 Q9VPU1 ecdysteroid biosynthetic process; extracellular space; lipid antigen binding; lipopolysaccharide binding; lipoteichoic acid binding; peptidoglycan binding; peptidoglycan recognition protein signaling pathway; sterol homeostasis; sterol transport; synaptic target recognition IPR014756; IPR003172; Protein NPC2 homolog (Niemann Pick type C2 protein homolog) Npc2a NPC2 CG7291 Drosophila melanogaster (Fruit fly) TR18067_c3_g1_i1 Q9CZJ2 HS12B_MOUSE 2.00E-13 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR18081_c0_g1_i1 A6NE52 K1875_HUMAN 3.00E-13 IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein KIAA1875 KIAA1875 Homo sapiens (Human) TR18085_c2_g1_i1 P08548 LIN1_NYCCO 5.00E-09 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR18086_c0_g1_i1 A6NNX1 RIAD1_HUMAN 2.00E-19 IPR003117; RIIa domain-containing protein 1 RIIAD1 C1orf230 Homo sapiens (Human) TR18090_c0_g1_i1 Q8R367 RERG_MOUSE 1.00E-10 GO:0005525; GO:0003924; GO:0005829; GO:0016020; GO:0030308; GO:0008285; GO:0005634; GO:0009725; GO:0007264 GTP binding; GTPase activity; cytosol; membrane; negative regulation of cell growth; negative regulation of cell proliferation; nucleus; response to hormone stimulus; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; Ras-related and estrogen-regulated growth inhibitor Rerg Mus musculus (Mouse) TR18092_c1_g1_i1 O93530 WRN_XENLA 2.00E-11 GO:0008408; GO:0005524; GO:0043140; GO:0003677; GO:0006259; GO:0006310; GO:0006281; GO:0006260; GO:0000287; GO:0030145; GO:0005634 3'-5' exonuclease activity; ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA binding; DNA metabolic process; DNA recombination; DNA repair; DNA replication; magnesium ion binding; manganese ion binding; nucleus IPR002562; IPR011545; IPR004589; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR012337; IPR018982; IPR011991; Werner syndrome ATP-dependent helicase homolog (EC 3.6.4.12) (Exonuclease WRN) (EC 3.1.-.-) (Focus-forming activity 1) (FFA-1) wrn ffa1 Xenopus laevis (African clawed frog) TR18097_c0_g1_i1 Q29J90 MOODY_DROPS 3.00E-10 GO:0004930; GO:0008366; GO:0048148; GO:0016021; GO:0005886 G-protein coupled receptor activity; axon ensheathment; behavioral response to cocaine; integral to membrane; plasma membrane IPR000276; IPR017452; G-protein coupled receptor moody moody GA18107 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR181_c0_g1_i1 P02598 CALM_TETPY 4.00E-94 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Tetrahymena pyriformis TR18103_c0_g1_i1 Q5U5A6 NRARP_XENLA 3.00E-25 GO:0007219; GO:0007275; GO:0006355; GO:0006351 "Notch signaling pathway; multicellular organismal development; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002110; IPR020683; Notch-regulated ankyrin repeat-containing protein nrarp Xenopus laevis (African clawed frog) TR18108_c0_g1_i1 Q9Y2B2 PIGL_HUMAN 1.00E-24 GO:0006501; GO:0000225; GO:0005789; GO:0016021; GO:0016254 C-terminal protein lipidation; N-acetylglucosaminylphosphatidylinositol deacetylase activity; endoplasmic reticulum membrane; integral to membrane; preassembly of GPI anchor in ER membrane IPR003737; IPR024078; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC 3.5.1.89) (Phosphatidylinositol-glycan biosynthesis class L protein) (PIG-L) PIGL Homo sapiens (Human) TR18108_c2_g1_i1 O35790 PIGL_RAT 6.00E-21 GO:0006506; GO:0000225; GO:0042406; GO:0016021 GPI anchor biosynthetic process; N-acetylglucosaminylphosphatidylinositol deacetylase activity; extrinsic to endoplasmic reticulum membrane; integral to membrane IPR003737; IPR024078; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC 3.5.1.89) (Phosphatidylinositol-glycan biosynthesis class L protein) (PIG-L) Pigl Rattus norvegicus (Rat) TR18109_c0_g1_i1 Q9VR07 INE_DROME 4.00E-10 GO:0016021; GO:0005328; GO:0005034; GO:0042066; GO:0009881; GO:0005886; GO:0047484; GO:0019226 integral to membrane; neurotransmitter:sodium symporter activity; osmosensor activity; perineurial glial growth; photoreceptor activity; plasma membrane; regulation of response to osmotic stress; transmission of nerve impulse IPR000175; IPR002944; Sodium- and chloride-dependent GABA transporter ine (Protein inebriated) (Protein receptor oscillation A) ine rosA CG15444 Drosophila melanogaster (Fruit fly) TR18110_c1_g1_i1 P91889 FMRF_SEPOF 1.00E-34 GO:0005576; GO:0007218 extracellular region; neuropeptide signaling pathway IPR002544; FMRFamide-related neuropeptides [Cleaved into: FIRF-amide; ALSGDAFLRF-amide; FLRF-amide; FMRF-amide 1; FMRF-amide 2; FMRF-amide 3; FMRF-amide 4; FMRF-amide 5; FMRF-amide 6; FMRF-amide 7; FMRF-amide 8; FMRF-amide 9; FMRF-amide 10; FMRF-amide 11] FMRFa Sepia officinalis (Common cuttlefish) TR18111_c0_g2_i1 Q6NUB7 ZRN1B_XENLA 0 GO:0016055; GO:0016477; GO:0005737; GO:0007010; GO:0005634; GO:0030177; GO:0035523; GO:1990168; GO:0070536; GO:0006508; GO:0022604; GO:0004221; GO:0004843; GO:0008270 Wnt receptor signaling pathway; cell migration; cytoplasm; cytoskeleton organization; nucleus; positive regulation of Wnt receptor signaling pathway; protein K29-linked deubiquitination; protein K33-linked deubiquitination; protein K63-linked deubiquitination; proteolysis; regulation of cell morphogenesis; ubiquitin thiolesterase activity; ubiquitin-specific protease activity; zinc ion binding IPR003323; IPR001876; Ubiquitin thioesterase zranb1-B (EC 3.4.19.12) (Zinc finger Ran-binding domain-containing protein 1B) zranb1-b Xenopus laevis (African clawed frog) TR18111_c0_g3_i1 Q6NUB7 ZRN1B_XENLA 6.00E-35 GO:0016055; GO:0016477; GO:0005737; GO:0007010; GO:0005634; GO:0030177; GO:0035523; GO:1990168; GO:0070536; GO:0006508; GO:0022604; GO:0004221; GO:0004843; GO:0008270 Wnt receptor signaling pathway; cell migration; cytoplasm; cytoskeleton organization; nucleus; positive regulation of Wnt receptor signaling pathway; protein K29-linked deubiquitination; protein K33-linked deubiquitination; protein K63-linked deubiquitination; proteolysis; regulation of cell morphogenesis; ubiquitin thiolesterase activity; ubiquitin-specific protease activity; zinc ion binding IPR003323; IPR001876; Ubiquitin thioesterase zranb1-B (EC 3.4.19.12) (Zinc finger Ran-binding domain-containing protein 1B) zranb1-b Xenopus laevis (African clawed frog) TR1812_c0_g1_i1 Q7ZT98 CRVP_OPHHA 3.00E-07 GO:0005576 extracellular region IPR001283; IPR018244; IPR014044; IPR013871; IPR003582; Cysteine-rich venom protein ophanin (CRVP) (Opharin) Ophiophagus hannah (King cobra) (Naja hannah) TR18120_c1_g1_i1 Q9QZ85 IIGP1_MOUSE 2.00E-14 GO:0019003; GO:0005525; GO:0003924; GO:0032580; GO:0035458; GO:0019221; GO:0050829; GO:0042832; GO:0005789; GO:0042802; GO:0045087; GO:0031965; GO:0010506; GO:0020005 GDP binding; GTP binding; GTPase activity; Golgi cisterna membrane; cellular response to interferon-beta; cytokine-mediated signaling pathway; defense response to Gram-negative bacterium; defense response to protozoan; endoplasmic reticulum membrane; identical protein binding; innate immune response; nuclear membrane; regulation of autophagy; symbiont-containing vacuole membrane IPR007743; IPR027417; Interferon-inducible GTPase 1 (EC 3.6.5.-) Iigp1 Irga6 Mus musculus (Mouse) TR1813_c0_g1_i1 Q9UAS2 FABP1_FASGI 5.00E-09 GO:0008289; GO:0005215 lipid binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; Fatty acid-binding protein 1 FABP-1 Fasciola gigantica (Giant liver fluke) TR18140_c0_g1_i1 Q5Q995 KTAP2_IXOSC 9.00E-39 GO:0005615; GO:0016021 extracellular space; integral to membrane IPR018614; Protein KRTCAP2 homolog Ixodes scapularis (Black-legged tick) (Deer tick) TR18142_c0_g1_i1 Q8HYJ6 FUT6_GORGO 9.00E-08 GO:0017060; GO:0032580; GO:0036065; GO:0016021; GO:0006486 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity; Golgi cisterna membrane; fucosylation; integral to membrane; protein glycosylation IPR001503; Protein modification; protein glycosylation. "Alpha-(1,3)-fucosyltransferase 6 (EC 2.4.1.65) (Fucosyltransferase 6) (Fucosyltransferase VI) (Fuc-TVI) (FucT-VI) (Galactoside 3-L-fucosyltransferase)" FUT6 Gorilla gorilla gorilla (Lowland gorilla) TR18149_c0_g1_i1 P69150 H31_TETTH 4.00E-66 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR000164; Histone H3 (H3S) (Histone H3-I/H3-II) (Major histone H3) [Cleaved into: H3F] HHT1 TTHERM_00570560; HHT2 TTHERM_00189180 Tetrahymena thermophila TR18149_c0_g2_i1 P83864 H3_LITVA 1.00E-07 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR000164; Histone H3 (Fragments) Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei) TR18150_c0_g1_i1 Q90953 CSPG2_CHICK 1.00E-12 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Gallus gallus (Chicken) TR18150_c1_g1_i1 P13944 COCA1_CHICK 6.00E-10 GO:0007155; GO:0005581 cell adhesion; collagen IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain (Fibrochimerin) COL12A1 Gallus gallus (Chicken) TR18151_c0_g1_i1 Q7Z2D5 LPPR4_HUMAN 4.00E-09 GO:0016021; GO:0008152; GO:0008195 integral to membrane; metabolic process; phosphatidate phosphatase activity IPR000326; Lipid phosphate phosphatase-related protein type 4 (EC 3.1.3.4) (Brain-specific phosphatidic acid phosphatase-like protein 1) (Plasticity-related gene 1 protein) (PRG-1) LPPR4 KIAA0455 PRG1 Homo sapiens (Human) TR18168_c2_g1_i1 Q8VI47 MRP2_MOUSE 3.00E-06 GO:0005524; GO:0006200; GO:0042626; GO:0016324; GO:0005887; GO:0046581 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; apical plasma membrane; integral to plasma membrane; intercellular canaliculus" IPR003593; IPR011527; IPR003439; IPR001140; IPR005292; IPR027417; Canalicular multispecific organic anion transporter 1 (ATP-binding cassette sub-family C member 2) Abcc2 Mus musculus (Mouse) TR18172_c0_g1_i1 Q9JKS4 LDB3_MOUSE 3.00E-06 GO:0030018; GO:0005856; GO:0051371; GO:0048471; GO:0005080; GO:0031143; GO:0045214; GO:0008270 Z disc; cytoskeleton; muscle alpha-actinin binding; perinuclear region of cytoplasm; protein kinase C binding; pseudopodium; sarcomere organization; zinc ion binding IPR001478; IPR006643; IPR001781; LIM domain-binding protein 3 (Protein cypher) (Protein oracle) (Z-band alternatively spliced PDZ-motif protein) Ldb3 Kiaa0613 Mus musculus (Mouse) TR18177_c0_g1_i1 A2AHJ4 BRWD3_MOUSE 3.00E-87 GO:0007010; GO:0008360 cytoskeleton organization; regulation of cell shape IPR001487; IPR015943; IPR001680; IPR019775; IPR017986; Bromodomain and WD repeat-containing protein 3 Brwd3 Gm596 Mus musculus (Mouse) TR18177_c2_g1_i1 Q9UIG0 BAZ1B_HUMAN 5.00E-10 GO:0005524; GO:0043044; GO:0034725; GO:0071778; GO:0005721; GO:0003682; GO:0048096; GO:0000793; GO:0006302; GO:0003007; GO:0070577; GO:0035173; GO:0004715; GO:0032947; GO:0004713; GO:0006351; GO:0071884; GO:0008270 O60264 "ATP binding; ATP-dependent chromatin remodeling; DNA replication-dependent nucleosome disassembly; WINAC complex; centromeric heterochromatin; chromatin binding; chromatin-mediated maintenance of transcription; condensed chromosome; double-strand break repair; heart morphogenesis; histone acetyl-lysine binding; histone kinase activity; non-membrane spanning protein tyrosine kinase activity; protein complex scaffold; protein tyrosine kinase activity; transcription, DNA-dependent; vitamin D receptor activator activity; zinc ion binding" IPR001487; IPR018359; IPR018500; IPR018501; IPR013136; IPR019786; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) BAZ1B WBSC10 WBSCR10 WBSCR9 WSTF Homo sapiens (Human) TR18179_c0_g1_i1 O15974 OPSD2_MIZYE 8.00E-20 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR002962; IPR027430; "Rhodopsin, G0-coupled (G0-rhodopsin)" SCOP2 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) TR18179_c0_g3_i1 Q6VZZ7 OPN5_MOUSE 1.00E-15 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR002962; IPR027430; Opsin-5 (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Neuropsin) Opn5 Gpr136 Pgr12 Mus musculus (Mouse) TR18180_c3_g1_i1 Q80SU7 GVIN1_MOUSE 2.00E-07 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR027417; Interferon-induced very large GTPase 1 (Very large-inducible GTPase-1) (VLIG-1) Gvin1 Mus musculus (Mouse) TR18187_c0_g1_i1 A6QLU6 GP133_BOVIN 8.00E-13 GO:0004930; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR008985; IPR013320; IPR017981; IPR000832; IPR017983; IPR000203; Probable G-protein coupled receptor 133 GPR133 Bos taurus (Bovine) TR18196_c1_g2_i1 Q9CUX1 P52K_MOUSE 6.00E-16 GO:0003677; GO:0046872; GO:0005634 DNA binding; metal ion binding; nucleus IPR025398; IPR008906; IPR012337; IPR006612; 52 kDa repressor of the inhibitor of the protein kinase (p52rIPK) (58 kDa interferon-induced protein kinase-interacting protein) (p58IPK-interacting protein) (THAP domain-containing protein 0) Prkrir Thap0 Mus musculus (Mouse) TR18199_c0_g1_i1 Q08BB2 P2012_DANRE 1.00E-29 GO:0005576; GO:0046872; GO:0008233; GO:0006508 extracellular region; metal ion binding; peptidase activity; proteolysis IPR002933; IPR011650; Probable carboxypeptidase PM20D1.2 (EC 3.4.17.-) (Peptidase M20 domain-containing protein 1.2) pm20d1.2 zgc:154035 Danio rerio (Zebrafish) (Brachydanio rerio) TR18204_c0_g1_i1 Q14204 DYHC1_HUMAN 8.00E-77 GO:0005524; GO:0042623; GO:0000086; GO:0005794; GO:0019886; GO:0008219; GO:0005813; GO:0005868; GO:0033962; GO:0005829; GO:0070062; GO:0005874; GO:0003777; GO:0007018; GO:0007052; GO:0034063; GO:0006810 Q9NRI5; P49810 "ATP binding; ATPase activity, coupled; G2/M transition of mitotic cell cycle; Golgi apparatus; antigen processing and presentation of exogenous peptide antigen via MHC class II; cell death; centrosome; cytoplasmic dynein complex; cytoplasmic mRNA processing body assembly; cytosol; extracellular vesicular exosome; microtubule; microtubule motor activity; microtubule-based movement; mitotic spindle organization; stress granule assembly; transport" IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)" DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 Homo sapiens (Human) TR18204_c2_g1_i1 P38650 DYHC1_RAT 1.00E-58 GO:0005524; GO:0006200; GO:0016887; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement; transport IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) (MAP 1C)" Dync1h1 Dhc1 Dnch1 Dnchc1 Dnec1 Dyhc Map1c Rattus norvegicus (Rat) TR18205_c0_g2_i1 Q8R081 HNRPL_MOUSE 2.00E-25 GO:0003723; GO:0005737; GO:0006397; GO:0005654; GO:0000166; GO:0045120; GO:0030529; GO:0044212 RNA binding; cytoplasm; mRNA processing; nucleoplasm; nucleotide binding; pronucleus; ribonucleoprotein complex; transcription regulatory region DNA binding IPR006536; IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein L (hnRNP L) Hnrnpl Hnrpl Mus musculus (Mouse) TR18209_c0_g1_i1 Q9UIF8 BAZ2B_HUMAN 4.00E-06 GO:0003677; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001487; IPR018359; IPR004022; IPR018500; IPR018501; IPR016177; IPR001739; IPR011011; IPR001965; IPR019787; IPR013083; Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) BAZ2B KIAA1476 Homo sapiens (Human) TR18210_c0_g1_i1 Q9WV04 KIF9_MOUSE 2.00E-85 GO:0005524; GO:0005829; GO:0005871; GO:0005874; GO:0003777; GO:0007018 ATP binding; cytosol; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF9 Kif9 Mus musculus (Mouse) TR18211_c0_g1_i1 Q3ZCX4 ZN568_HUMAN 3.00E-54 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 568 ZNF568 Homo sapiens (Human) TR18213_c1_g1_i1 Q9JIX5 CHD8_RAT 5.00E-09 GO:0005524; GO:0043044; GO:0003677; GO:0003678; GO:0008094; GO:0071339; GO:0008013; GO:0060070; GO:0001701; GO:0035064; GO:0030178; GO:0043066; GO:0045892; GO:0002039; GO:0045944; GO:0045945; GO:0006351 "ATP binding; ATP-dependent chromatin remodeling; DNA binding; DNA helicase activity; DNA-dependent ATPase activity; MLL1 complex; beta-catenin binding; canonical Wnt receptor signaling pathway; in utero embryonic development; methylated histone residue binding; negative regulation of Wnt receptor signaling pathway; negative regulation of apoptotic process; negative regulation of transcription, DNA-dependent; p53 binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; transcription, DNA-dependent" IPR006576; IPR023780; IPR000953; IPR016197; IPR014001; IPR001650; IPR027417; IPR000330; Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Axis duplication inhibitor) (Duplin) Chd8 Rattus norvegicus (Rat) TR18222_c0_g1_i1 Q95JD5 ST1B1_CANFA 5.00E-12 GO:0004062; GO:0005737; GO:0009812; GO:0008202; GO:0051923; GO:0042403; GO:0006805 aryl sulfotransferase activity; cytoplasm; flavonoid metabolic process; steroid metabolic process; sulfation; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (cSULT1B1) (EC 2.8.2.-) SULT1B1 ST1B2 Canis familiaris (Dog) (Canis lupus familiaris) TR18231_c0_g2_i1 P08548 LIN1_NYCCO 9.00E-33 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR18234_c1_g1_i1 Q09499 IRE1_CAEEL 4.00E-09 GO:0005524; GO:0030969; GO:0004521; GO:0030176; GO:0002119; GO:0004674 ATP binding; UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response; endoribonuclease activity; integral to endoplasmic reticulum membrane; nematode larval development; protein serine/threonine kinase activity IPR010513; IPR011009; IPR018391; IPR002372; IPR000719; IPR006567; IPR027295; IPR011047; IPR008271; Serine/threonine-protein kinase/endoribonuclease ire-1 (Inositol-requiring protein 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] ire-1 C41C4.4 Caenorhabditis elegans TR18241_c0_g1_i1 Q40588 ASO_TOBAC 7.00E-27 GO:0008447; GO:0005507; GO:0005576 L-ascorbate oxidase activity; copper ion binding; extracellular region IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; IPR017760; L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) AAO Nicotiana tabacum (Common tobacco) TR18248_c2_g1_i1 Q24119 TRH_DROME 1.00E-32 GO:0007443; GO:0048813; GO:0007425; GO:0072175; GO:0046331; GO:0005634; GO:0046982; GO:0007435; GO:0043565; GO:0000981; GO:0004871; GO:0035277 "Malpighian tubule morphogenesis; dendrite morphogenesis; epithelial cell fate determination, open tracheal system; epithelial tube formation; lateral inhibition; nucleus; protein heterodimerization activity; salivary gland morphogenesis; sequence-specific DNA binding; sequence-specific DNA binding RNA polymerase II transcription factor activity; signal transducer activity; spiracle morphogenesis, open tracheal system" IPR011598; IPR001610; IPR000014; IPR013767; IPR013655; Protein trachealess trh CG6883 Drosophila melanogaster (Fruit fly) TR18249_c0_g1_i1 Q14686 NCOA6_HUMAN 3.00E-19 GO:0006310; GO:0006281; GO:0006260; GO:0007420; GO:0044255; GO:0003682; GO:0030331; GO:0042921; GO:0007507; GO:0035097; GO:0030520; GO:0060716; GO:0030374; GO:0030099; GO:0045944; GO:0009725; GO:0046965; GO:0044281; GO:0046966; GO:0005667; GO:0006367 P10275; Q92793; Q8NEZ4; O14686; P06400 DNA recombination; DNA repair; DNA replication; brain development; cellular lipid metabolic process; chromatin binding; estrogen receptor binding; glucocorticoid receptor signaling pathway; heart development; histone methyltransferase complex; intracellular estrogen receptor signaling pathway; labyrinthine layer blood vessel development; ligand-dependent nuclear receptor transcription coactivator activity; myeloid cell differentiation; positive regulation of transcription from RNA polymerase II promoter; response to hormone stimulus; retinoid X receptor binding; small molecule metabolic process; thyroid hormone receptor binding; transcription factor complex; transcription initiation from RNA polymerase II promoter IPR026638; "Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)" NCOA6 AIB3 KIAA0181 RAP250 TRBP Homo sapiens (Human) TR18251_c1_g1_i1 Q94516 AT5F1_DROME 1.00E-35 GO:0015986; GO:0005811; GO:0000276; GO:0006909; GO:0046933 "ATP synthesis coupled proton transport; lipid particle; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); phagocytosis; proton-transporting ATP synthase activity, rotational mechanism" IPR008688; IPR013837; "ATP synthase subunit b, mitochondrial (ATPase subunit b) (FO-ATP synthase subunit b)" ATPsyn-b ATPsyn-beta CG8189 Drosophila melanogaster (Fruit fly) TR18255_c1_g1_i1 Q08477 CP4F3_HUMAN 2.00E-43 GO:0052871; GO:0019369; GO:0005789; GO:0020037; GO:0016021; GO:0005506; GO:0036101; GO:0050051; GO:0004497; GO:0006805 alpha-tocopherol omega-hydroxylase activity; arachidonic acid metabolic process; endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding; leukotriene B4 catabolic process; leukotriene-B4 20-monooxygenase activity; monooxygenase activity; xenobiotic metabolic process IPR001128; IPR017972; IPR002401; Lipid metabolism; leukotriene B4 degradation. Leukotriene-B(4) omega-hydroxylase 2 (EC 1.14.13.30) (CYPIVF3) (Cytochrome P450 4F3) (Cytochrome P450-LTB-omega) (Leukotriene-B(4) 20-monooxygenase 2) CYP4F3 LTB4H Homo sapiens (Human) TR18255_c1_g2_i1 Q42600 C84A1_ARATH 4.00E-09 GO:0005783; GO:0020037; GO:0016021; GO:0005506; GO:0009809; GO:0004497; GO:0016705; GO:0010224 "endoplasmic reticulum; heme binding; integral to membrane; iron ion binding; lignin biosynthetic process; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; response to UV-B" IPR001128; IPR017972; IPR002401; Aromatic compound metabolism; phenylpropanoid biosynthesis. Cytochrome P450 84A1 (EC 1.14.-.-) (Ferulate-5-hydroxylase) (F5H) CYP84A1 FAH1 At4g36220 F23E13.110 Arabidopsis thaliana (Mouse-ear cress) TR18262_c0_g2_i1 Q05941 ACHA7_RAT 3.00E-10 GO:0051117; GO:0042113; GO:0042110; GO:0042166; GO:0004889; GO:0005892; GO:0016324; GO:0008306; GO:0032279; GO:0030424; GO:0048149; GO:0035095; GO:0006816; GO:0030054; GO:0005737; GO:0043198; GO:0043197; GO:0042416; GO:0008144; GO:0006897; GO:0009897; GO:0060112; GO:0030426; GO:0045121; GO:0007613; GO:0050728; GO:0032691; GO:0032715; GO:0032720; GO:0043025; GO:0001988; GO:0014069; GO:0045211; GO:0042734; GO:0019228; GO:0014061; GO:0032225; GO:0032094; GO:0097110; GO:0030317; GO:0007271 "ATPase binding; B cell activation; T cell activation; acetylcholine binding; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; apical plasma membrane; associative learning; asymmetric synapse; axon; behavioral response to ethanol; behavioral response to nicotine; calcium ion transport; cell junction; cytoplasm; dendritic shaft; dendritic spine; dopamine biosynthetic process; drug binding; endocytosis; external side of plasma membrane; generation of ovulation cycle rhythm; growth cone; membrane raft; memory; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production; neuronal cell body; positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure; postsynaptic density; postsynaptic membrane; presynaptic membrane; regulation of action potential in neuron; regulation of norepinephrine secretion; regulation of synaptic transmission, dopaminergic; response to food; scaffold protein binding; sperm motility; synaptic transmission, cholinergic" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-7 Chrna7 Acra7 Rattus norvegicus (Rat) TR18266_c0_g1_i1 P45842 RL34_AEDAL 2.00E-45 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR008195; IPR018065; 60S ribosomal protein L34 (L31) RpL34 RpL31 Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta) TR18267_c0_g2_i1 Q5XHH9 TT39B_XENLA 4.00E-06 IPR019412; IPR011990; IPR001440; Tetratricopeptide repeat protein 39B (TPR repeat protein 39B) ttc39b Xenopus laevis (African clawed frog) TR18267_c1_g1_i1 Q8N584 TT39C_HUMAN 3.00E-43 IPR019412; IPR011990; Tetratricopeptide repeat protein 39C (TPR repeat protein 39C) TTC39C C18orf17 Homo sapiens (Human) TR18268_c3_g1_i1 Q8K3I9 GLCI1_MOUSE 3.00E-15 GO:0005737 cytoplasm IPR026639; IPR026642; Glucocorticoid-induced transcript 1 protein (Glucocorticoid-induced gene 18 protein) (Testhymin) (Thymocyte/spermatocyte selection protein 1) Glcci1 Gig18 Tssn1 Mus musculus (Mouse) TR18280_c0_g1_i1 P18146 EGR1_HUMAN 2.00E-07 GO:0030509; GO:0001077; GO:0000979; GO:0030217; GO:0071236; GO:0071320; GO:0035690; GO:0071372; GO:0071480; GO:0071371; GO:0071363; GO:0071504; GO:0071455; GO:0071456; GO:0032869; GO:0071317; GO:0071260; GO:0071506; GO:0071383; GO:0007623; GO:0005737; GO:0003690; GO:0072110; GO:0070498; GO:0007611; GO:0060291; GO:0046872; GO:0043066; GO:0090090; GO:0000122; GO:0005654; GO:0048709; GO:0072303; GO:0043525; GO:0045944; GO:0048169; GO:0033233; GO:0001975; GO:0034465; GO:0042220; GO:0051602; GO:0045471; GO:0009749; GO:0071873; GO:0031667; GO:0003700; GO:0035914; GO:0006366; GO:0000976; GO:0060337 Q8N726; P35222 BMP signaling pathway; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II core promoter sequence-specific DNA binding; T cell differentiation; cellular response to antibiotic; cellular response to cAMP; cellular response to drug; cellular response to follicle-stimulating hormone stimulus; cellular response to gamma radiation; cellular response to gonadotropin stimulus; cellular response to growth factor stimulus; cellular response to heparin; cellular response to hyperoxia; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to isoquinoline alkaloid; cellular response to mechanical stimulus; cellular response to mycophenolic acid; cellular response to steroid hormone stimulus; circadian rhythm; cytoplasm; double-stranded DNA binding; glomerular mesangial cell proliferation; interleukin-1-mediated signaling pathway; learning or memory; long-term synaptic potentiation; metal ion binding; negative regulation of apoptotic process; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; oligodendrocyte differentiation; positive regulation of glomerular metanephric mesangial cell proliferation; positive regulation of neuron apoptotic process; positive regulation of transcription from RNA polymerase II promoter; regulation of long-term neuronal synaptic plasticity; regulation of protein sumoylation; response to amphetamine; response to carbon monoxide; response to cocaine; response to electrical stimulus; response to ethanol; response to glucose stimulus; response to norepinephrine stimulus; response to nutrient levels; sequence-specific DNA binding transcription factor activity; skeletal muscle cell differentiation; transcription from RNA polymerase II promoter; transcription regulatory region sequence-specific DNA binding; type I interferon-mediated signaling pathway IPR021839; IPR021849; IPR007087; IPR015880; IPR013087; Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24) EGR1 KROX24 ZNF225 Homo sapiens (Human) TR18296_c0_g1_i1 Q9V8R9 41_DROME 8.00E-06 GO:0007527; GO:0061343; GO:0008362; GO:0008092; GO:0005856; GO:0007391; GO:0060857; GO:0007163; GO:0003015; GO:0035321; GO:0005886; GO:0006612; GO:0035151; GO:0007435; GO:0019991; GO:0005920; GO:0005198 "adult somatic muscle development; cell adhesion involved in heart morphogenesis; chitin-based embryonic cuticle biosynthetic process; cytoskeletal protein binding; cytoskeleton; dorsal closure; establishment of glial blood-brain barrier; establishment or maintenance of cell polarity; heart process; maintenance of imaginal disc-derived wing hair orientation; plasma membrane; protein targeting to membrane; regulation of tube size, open tracheal system; salivary gland morphogenesis; septate junction assembly; smooth septate junction; structural molecule activity" IPR008379; IPR019749; IPR019750; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; Protein 4.1 homolog (Protein coracle) cora CG11949 Drosophila melanogaster (Fruit fly) TR18303_c2_g1_i1 Q80U62 RUBIC_MOUSE 3.00E-106 GO:0005794; GO:0006914; GO:0005769; GO:0006897; GO:0005770; GO:0005764; GO:0010507; GO:0045806 Golgi apparatus; autophagy; early endosome; endocytosis; late endosome; lysosome; negative regulation of autophagy; negative regulation of endocytosis IPR025258; IPR004012; Run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) Kiaa0226 Mus musculus (Mouse) TR1831_c0_g1_i1 Q8K0U4 HS12A_MOUSE 4.00E-11 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR18318_c0_g1_i1 Q14162 SREC_HUMAN 5.00E-06 GO:0007155; GO:0006707; GO:0016358; GO:0030666; GO:0016021; GO:0030169; GO:0016322; GO:0005886; GO:0048680; GO:0005044; GO:0004888 cell adhesion; cholesterol catabolic process; dendrite development; endocytic vesicle membrane; integral to membrane; low-density lipoprotein particle binding; neuron remodeling; plasma membrane; positive regulation of axon regeneration; scavenger receptor activity; transmembrane signaling receptor activity IPR000742; IPR013032; IPR002049; IPR009030; Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) TR18324_c1_g1_i1 P25391 LAMA1_HUMAN 9.00E-10 GO:0007411; GO:0060445; GO:0007155; GO:0007166; GO:0005911; GO:0060441; GO:0045198; GO:0030198; GO:0005201; GO:0005615; GO:0043208; GO:0005606; GO:0005608; GO:0002011; GO:0030155; GO:0030334; GO:0045995; GO:0061304 Q8BDF8 axon guidance; branching involved in salivary gland morphogenesis; cell adhesion; cell surface receptor signaling pathway; cell-cell junction; epithelial tube branching involved in lung morphogenesis; establishment of epithelial cell apical/basal polarity; extracellular matrix organization; extracellular matrix structural constituent; extracellular space; glycosphingolipid binding; laminin-1 complex; laminin-3 complex; morphogenesis of an epithelial sheet; regulation of cell adhesion; regulation of cell migration; regulation of embryonic development; retinal blood vessel morphogenesis IPR008985; IPR013320; IPR002049; IPR018031; IPR000034; IPR001791; IPR009254; IPR010307; IPR008211; Laminin subunit alpha-1 (Laminin A chain) (Laminin-1 subunit alpha) (Laminin-3 subunit alpha) (S-laminin subunit alpha) (S-LAM alpha) LAMA1 LAMA Homo sapiens (Human) TR18326_c2_g1_i1 Q9UA35 S28A3_EPTST 3.00E-17 GO:0016021; GO:0005415 integral to membrane; nucleoside:sodium symporter activity IPR008276; IPR018270; IPR011657; IPR002668; Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT) SLC28A3 CNT3 Eptatretus stoutii (Pacific hagfish) TR18328_c0_g1_i1 Q1IJS7 NDK_KORVE 7.00E-07 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0005737; GO:0046872; GO:0004550 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; cytoplasm; metal ion binding; nucleoside diphosphate kinase activity IPR001564; Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) (Nucleoside-2-P kinase) ndk Acid345_3873 Koribacter versatilis (strain Ellin345) TR18330_c1_g1_i1 Q9MYM7 B3GT1_PONPY 7.00E-12 GO:0000139; GO:0008378; GO:0016021; GO:0006486 Golgi membrane; galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) TR18334_c0_g1_i1 Q8K480 MFRP_MOUSE 7.00E-07 GO:0016021 integral to membrane IPR000859; IPR020067; IPR023415; IPR002172; Membrane frizzled-related protein (Membrane-type frizzled-related protein) Mfrp Mus musculus (Mouse) TR18335_c1_g1_i1 Q8BVI5 STX16_MOUSE 7.00E-30 GO:0005794; GO:0000139; GO:0016021; GO:0006886; GO:0042147 O08700 "Golgi apparatus; Golgi membrane; integral to membrane; intracellular protein transport; retrograde transport, endosome to Golgi" IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin-16 Stx16 Mus musculus (Mouse) TR18336_c2_g1_i1 Q9QYP1 LRP4_RAT 1.00E-07 GO:0016055; GO:0005509; GO:0030154; GO:0009953; GO:0042733; GO:0006897; GO:0001942; GO:0016021; GO:0001822; GO:0090090; GO:0030279; GO:0042475; GO:0005886; GO:0009954; GO:0043113; GO:0001932; GO:0051124 Wnt receptor signaling pathway; calcium ion binding; cell differentiation; dorsal/ventral pattern formation; embryonic digit morphogenesis; endocytosis; hair follicle development; integral to membrane; kidney development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of ossification; odontogenesis of dentin-containing tooth; plasma membrane; proximal/distal pattern formation; receptor clustering; regulation of protein phosphorylation; synaptic growth at neuromuscular junction IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) Lrp4 Megf7 Rattus norvegicus (Rat) TR18343_c1_g1_i1 Q18297 TRPA1_CAEEL 1.00E-08 GO:0016021; GO:0005216; GO:0043025; GO:0031513; GO:0050896 integral to membrane; ion channel activity; neuronal cell body; nonmotile primary cilium; response to stimulus IPR002110; IPR020683; IPR005821; Transient receptor potential cation channel subfamily A member 1 homolog trpa-1 C29E6.2 Caenorhabditis elegans TR18343_c1_g2_i1 Q4UMH6 Y381_RICFE 2.00E-09 GO:0015969 guanosine tetraphosphate metabolic process IPR002110; IPR020683; IPR007685; Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR18343_c2_g1_i1 Q812A3 ANR23_MOUSE 7.00E-07 GO:0031674; GO:0015629; GO:0006631; GO:0005634 I band; actin cytoskeleton; fatty acid metabolic process; nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) Ankrd23 Darp Mus musculus (Mouse) TR18345_c2_g1_i1 P20825 POL2_DROME 4.00E-14 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR18345_c3_g1_i1 P20825 POL2_DROME 2.00E-35 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR18345_c4_g2_i1 P92523 M860_ARATH 6.00E-16 GO:0005739 mitochondrion Uncharacterized mitochondrial protein AtMg00860 (ORF158) AtMg00860 Arabidopsis thaliana (Mouse-ear cress) TR18351_c0_g2_i1 P74148 Y1388_SYNY3 3.00E-06 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein Sll1388 (USP Sll1388) sll1388 Synechocystis sp. (strain PCC 6803 / Kazusa) TR18352_c2_g1_i1 Q8N6F8 WBS27_HUMAN 7.00E-11 Williams-Beuren syndrome chromosomal region 27 protein WBSCR27 Homo sapiens (Human) TR18356_c0_g1_i1 P35832 PTP99_DROME 1.00E-26 GO:0030424; GO:0007415; GO:0016021; GO:0008045; GO:0005886; GO:0005001 axon; defasciculation of motor neuron axon; integral to membrane; motor neuron axon guidance; plasma membrane; transmembrane receptor protein tyrosine phosphatase activity IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase 99A (EC 3.1.3.48) (Receptor-linked protein-tyrosine phosphatase 99A) (DPTP99A) Ptp99A CG2005 Drosophila melanogaster (Fruit fly) TR18356_c4_g1_i1 P23470 PTPRG_HUMAN 5.00E-42 GO:0005887; GO:0007169; GO:0005001 P35222 integral to plasma membrane; transmembrane receptor protein tyrosine kinase signaling pathway; transmembrane receptor protein tyrosine phosphatase activity IPR001148; IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48) PTPRG PTPG Homo sapiens (Human) TR18356_c4_g2_i1 Q62656 PTPRZ_RAT 2.00E-39 GO:0016021; GO:0035335; GO:0004725 integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR001148; IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (3F8 chondroitin sulfate proteoglycan) (3H1 keratan sulfate proteoglycan) (Phosphacan) Ptprz1 Ptprz Ptpz Rattus norvegicus (Rat) TR18360_c3_g1_i1 Q6C5Y8 VAC8_YARLI 2.00E-13 GO:0005774; GO:0000011 vacuolar membrane; vacuole inheritance IPR011989; IPR016024; IPR000225; IPR026958; Vacuolar protein 8 VAC8 YALI0E13992g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR18361_c0_g1_i1 P0C6B8 SVEP1_RAT 7.00E-35 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) TR18361_c2_g1_i1 Q923P0 COKA1_MOUSE 3.00E-06 GO:0005581; GO:0005615 collagen; extracellular space IPR008160; IPR008985; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XX) chain Col20a1 Mus musculus (Mouse) TR18365_c0_g1_i1 Q6ZT12 UBR3_HUMAN 2.00E-21 GO:0009790; GO:0001701; GO:0016021; GO:0042048; GO:0007608; GO:0001967; GO:0006511; GO:0004842; GO:0008270 embryo development; in utero embryonic development; integral to membrane; olfactory behavior; sensory perception of smell; suckling behavior; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR003126; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UBR3 (EC 6.3.2.-) (N-recognin-3) (Ubiquitin-protein ligase E3-alpha-3) (Ubiquitin-protein ligase E3-alpha-III) (Zinc finger protein 650) UBR3 KIAA2024 ZNF650 Homo sapiens (Human) TR18366_c0_g1_i1 Q9SZ67 WRK19_ARATH 1.00E-08 GO:0043531; GO:0005524; GO:0009941; GO:0006952; GO:0017111; GO:0005634; GO:0004674; GO:0043565; GO:0003700; GO:0007165; GO:0006351 "ADP binding; ATP binding; chloroplast envelope; defense response; nucleoside-triphosphatase activity; nucleus; protein serine/threonine kinase activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; signal transduction; transcription, DNA-dependent" IPR003593; IPR000767; IPR000742; IPR011009; IPR001611; IPR011713; IPR002182; IPR027417; IPR003822; IPR000719; IPR002290; IPR000157; IPR003657; Probable WRKY transcription factor 19 (WRKY DNA-binding protein 19) WRKY19 At4g12020 F16J13.90 Arabidopsis thaliana (Mouse-ear cress) TR18366_c1_g1_i2 Q9Y2U5 M3K2_HUMAN 2.00E-14 GO:0005524; GO:0004709; GO:0007257; GO:0000186; GO:0071260; GO:0005737; GO:0046872; GO:0005634; GO:0045893; GO:0004674 Q9UNE7 "ATP binding; MAP kinase kinase kinase activity; activation of JUN kinase activity; activation of MAPKK activity; cellular response to mechanical stimulus; cytoplasm; metal ion binding; nucleus; positive regulation of transcription, DNA-dependent; protein serine/threonine kinase activity" IPR011009; IPR000270; IPR000719; IPR017441; IPR002290; Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) MAP3K2 MAPKKK2 MEKK2 Homo sapiens (Human) TR18366_c1_g1_i3 A4K2P5 STK4_COLGU 7.00E-15 GO:0005524; GO:0006915; GO:0005737; GO:0035329; GO:0046872; GO:0005634; GO:0004674 ATP binding; apoptotic process; cytoplasm; hippo signaling cascade; metal ion binding; nucleus; protein serine/threonine kinase activity IPR011009; IPR024205; IPR000719; IPR017441; IPR011524; IPR002290; Serine/threonine-protein kinase 4 (EC 2.7.11.1) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] STK4 Colobus guereza (Mantled guereza) (Eastern black-and-white colobus monkey) TR18370_c0_g2_i1 P30044 PRDX5_HUMAN 5.00E-35 GO:0070995; GO:0001016; GO:0016209; GO:0034614; GO:0043027; GO:0031410; GO:0005829; GO:0042744; GO:0006954; GO:0005739; GO:0043066; GO:0051354; GO:0016480; GO:0005634; GO:0048471; GO:0004601; GO:0051920; GO:0005782; GO:0005777; GO:0072541; GO:0032967; GO:0046983; GO:2001057; GO:0060785 NADPH oxidation; RNA polymerase III regulatory region DNA binding; antioxidant activity; cellular response to reactive oxygen species; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasmic vesicle; cytosol; hydrogen peroxide catabolic process; inflammatory response; mitochondrion; negative regulation of apoptotic process; negative regulation of oxidoreductase activity; negative regulation of transcription from RNA polymerase III promoter; nucleus; perinuclear region of cytoplasm; peroxidase activity; peroxiredoxin activity; peroxisomal matrix; peroxisome; peroxynitrite reductase activity; positive regulation of collagen biosynthetic process; protein dimerization activity; reactive nitrogen species metabolic process; regulation of apoptosis involved in tissue homeostasis IPR013740; IPR012336; "Peroxiredoxin-5, mitochondrial (EC 1.11.1.15) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin reductase)" PRDX5 ACR1 SBBI10 Homo sapiens (Human) TR18378_c1_g1_i1 P41183 BCL6_MOUSE 1.00E-28 GO:0030183; GO:0007266; GO:0030036; GO:0000902; GO:0031490; GO:0048821; GO:0002467; GO:0046872; GO:0035024; GO:0045629; GO:0043066; GO:0030308; GO:0008285; GO:0001953; GO:0048294; GO:0032764; GO:0000122; GO:0002829; GO:0005634; GO:0030890; GO:0043065; GO:0051272; GO:0000060; GO:0008104; GO:0032319; GO:0050727; GO:0043380; GO:0005657; GO:0006974; GO:0043565; GO:0003700; GO:0007283; GO:0006351; GO:0042092 Q9JKD8 "B cell differentiation; Rho protein signal transduction; actin cytoskeleton organization; cell morphogenesis; chromatin DNA binding; erythrocyte development; germinal center formation; metal ion binding; negative regulation of Rho protein signal transduction; negative regulation of T-helper 2 cell differentiation; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cell-matrix adhesion; negative regulation of isotype switching to IgE isotypes; negative regulation of mast cell cytokine production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of type 2 immune response; nucleus; positive regulation of B cell proliferation; positive regulation of apoptotic process; positive regulation of cellular component movement; protein import into nucleus, translocation; protein localization; regulation of Rho GTPase activity; regulation of inflammatory response; regulation of memory T cell differentiation; replication fork; response to DNA damage stimulus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; spermatogenesis; transcription, DNA-dependent; type 2 immune response" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; B-cell lymphoma 6 protein homolog Bcl6 Bcl-6 Mus musculus (Mouse) TR18378_c2_g1_i1 Q61624 ZN148_MOUSE 3.00E-22 GO:0003677; GO:0005794; GO:0003690; GO:0007276; GO:0046872; GO:0000122; GO:0005634; GO:0045944; GO:0006461; GO:0003700; GO:0000976; GO:0006351 "DNA binding; Golgi apparatus; double-stranded DNA binding; gamete generation; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of transcription from RNA polymerase II promoter; protein complex assembly; sequence-specific DNA binding transcription factor activity; transcription regulatory region sequence-specific DNA binding; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 148 (Beta enolase repressor factor 1) (G-rich box-binding protein) (Transcription factor BFCOL1) (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) Znf148 Zbp89 Zfp148 Mus musculus (Mouse) TR18380_c0_g1_i1 O35161 CELR1_MOUSE 9.00E-07 GO:0004930; GO:0007266; GO:0009952; GO:0045176; GO:0005509; GO:0007267; GO:0007417; GO:0048105; GO:0042249; GO:0001702; GO:0001942; GO:0007156; GO:0042472; GO:0005887; GO:0060490; GO:0007626; GO:0001843; GO:0001764; GO:0007218; GO:0060488; GO:0090179; GO:0060489; GO:0046983; GO:0090251; GO:0032956; GO:0046928; GO:0042060 Q7T0S3 G-protein coupled receptor activity; Rho protein signal transduction; anterior/posterior pattern specification; apical protein localization; calcium ion binding; cell-cell signaling; central nervous system development; establishment of body hair planar orientation; establishment of planar polarity of embryonic epithelium; gastrulation with mouth forming second; hair follicle development; homophilic cell adhesion; inner ear morphogenesis; integral to plasma membrane; lateral sprouting involved in lung morphogenesis; locomotory behavior; neural tube closure; neuron migration; neuropeptide signaling pathway; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis; planar cell polarity pathway involved in neural tube closure; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis; protein dimerization activity; protein localization involved in establishment of planar polarity; regulation of actin cytoskeleton organization; regulation of neurotransmitter secretion; wound healing IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR013032; IPR000152; IPR002049; IPR017981; IPR001879; IPR000832; IPR000203; IPR009030; IPR001791; Cadherin EGF LAG seven-pass G-type receptor 1 Celsr1 Mus musculus (Mouse) TR18384_c2_g1_i1 Q27746 DNMT1_PARLI 2.00E-54 GO:0003886; GO:0003677; GO:0005634; GO:0008270 DNA (cytosine-5-)-methyltransferase activity; DNA binding; nucleus; zinc ion binding IPR001025; IPR018117; IPR001525; IPR022702; IPR010506; IPR017198; IPR002857; DNA (cytosine-5)-methyltransferase PliMCI (EC 2.1.1.37) (DNA methyltransferase PliMCI) (DNA MTase PliMCI) (M.PliMCI) (Dnmt1) (MCMT) DNMT PLIMCIM Paracentrotus lividus (Common sea urchin) TR18386_c2_g1_i1 Q9FKC8 MT799_ARATH 3.00E-08 GO:0008168 methyltransferase activity IPR005299; Probable S-adenosylmethionine-dependent methyltransferase At5g37990 (EC 2.1.1.-) At5g37990 K18L3.150 Arabidopsis thaliana (Mouse-ear cress) TR18386_c2_g1_i2 Q9FYZ9 BAMT_ANTMA 2.00E-08 GO:0008168 methyltransferase activity IPR005299; Benzoate carboxyl methyltransferase (EC 2.1.1.-) (S-adenosyl-L-methionine:benzoic acid carboxyl methyltransferase) BAMT Antirrhinum majus (Garden snapdragon) TR18394_c0_g1_i1 Q03277 PO11_SCICO 3.00E-07 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis IPR005135; IPR000477; Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 (Retrovirus-related Pol polyprotein from type I retrotransposable element R1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] (Fragment) Sciara coprophila (Fungus gnat) TR18396_c0_g2_i1 Q9VZS3 SUI1_DROME 2.00E-43 GO:0071456; GO:0006417; GO:0003743 cellular response to hypoxia; regulation of translation; translation initiation factor activity IPR005874; IPR001950; Protein translation factor SUI1 homolog CG17737 Drosophila melanogaster (Fruit fly) TR18397_c1_g1_i1 P34269 TYR1_CAEEL 4.00E-29 GO:0046872; GO:0004497 metal ion binding; monooxygenase activity IPR003582; IPR002227; IPR008922; Putative tyrosinase-like protein tyr-1 tyr-1 C02C2.1/C02C2.2 Caenorhabditis elegans TR18399_c1_g1_i1 B1ANS9 WDR64_HUMAN 4.00E-21 IPR015943; IPR001680; IPR017986; WD repeat-containing protein 64 WDR64 Homo sapiens (Human) TR18400_c0_g1_i1 Q90Z12 HES4A_XENLA 2.00E-44 GO:0030509; GO:0008283; GO:0033504; GO:0002088; GO:0043066; GO:0000122; GO:0014029; GO:0005634; GO:0021501; GO:0043565; GO:0006351 "BMP signaling pathway; cell proliferation; floor plate development; lens development in camera-type eye; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter; neural crest formation; nucleus; prechordal plate formation; sequence-specific DNA binding; transcription, DNA-dependent" IPR011598; IPR003650; IPR018352; Transcription factor HES-4-A (Hairy and enhancer of split 4-A) (Protein hairy-2) (Xhairy2) (Protein hairy-2a) (Xhairy2a) hes4-a hairy2 hairy2a Xenopus laevis (African clawed frog) TR18404_c1_g1_i1 A6QLM0 TM189_BOVIN 3.00E-23 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR019547; Transmembrane protein 189 TMEM189 Bos taurus (Bovine) TR18408_c0_g1_i1 Q923L3 CSMD1_MOUSE 9.00E-06 GO:0016021 integral to membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 1 (CUB and sushi multiple domains protein 1) Csmd1 Mus musculus (Mouse) TR18413_c1_g1_i2 P49230 PROF_ENTHI 3.00E-09 GO:0030036; GO:0005737; GO:0005856 actin cytoskeleton organization; cytoplasm; cytoskeleton IPR027310; IPR005455; Profilin Entamoeba histolytica TR18418_c1_g1_i1 P23074 POL_SFV1 7.00E-08 GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0075713; GO:0030430; GO:0042025; GO:0046872; GO:0090305; GO:0006508; GO:0004523; GO:0046718; GO:0075732; GO:0019012 DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; establishment of integrated proviral latency; host cell cytoplasm; host cell nucleus; metal ion binding; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; viral entry into host cell; viral penetration into host nucleus; virion IPR001584; IPR012337; IPR002156; IPR000477; IPR001641; Pro-Pol polyprotein (Pr125Pol) [Cleaved into: Protease/Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (EC 3.4.23.-) (p87Pro-RT-RNaseH); Protease/Reverse transcriptase (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.4.23.-) (p65Pro-RT); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN) (p42In)] pol Simian foamy virus type 1 (SFVmac) (SFV-1) TR18418_c1_g2_i1 P10394 POL4_DROME 6.00E-09 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR18420_c1_g1_i1 Q9FT73 MED34_ARATH 4.00E-16 GO:0043138; GO:0005524; GO:0043140; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0009378; GO:0016592; GO:0046872; GO:0006355; GO:0006351 "3'-5' DNA helicase activity; ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA binding; DNA recombination; DNA repair; DNA replication; four-way junction helicase activity; mediator complex; metal ion binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011545; IPR004589; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR018982; IPR011991; Mediator of RNA polymerase II transcription subunit 34 (ATP-dependent DNA helicase Q-like 2) (EC 3.6.4.12) (RecQ-like protein 2) (AtRecQ2) (AtRecQl2) MED34 MED34_1 RECQ2 RECQL2 RQL2 At1g31360 T19E23.16 Arabidopsis thaliana (Mouse-ear cress) TR18422_c2_g1_i1 Q7L1S5 CHST9_HUMAN 1.00E-08 GO:0000139; GO:0001537; GO:0016051; GO:0005975; GO:0030206; GO:0005576; GO:0042446; GO:0016021 Golgi membrane; N-acetylgalactosamine 4-O-sulfotransferase activity; carbohydrate biosynthetic process; carbohydrate metabolic process; chondroitin sulfate biosynthetic process; extracellular region; hormone biosynthetic process; integral to membrane IPR018011; IPR005331; Carbohydrate sulfotransferase 9 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 2) (GalNAc-4-ST2) (GalNAc4ST-2) (N-acetylgalactosamine-4-O-sulfotransferase 2) CHST9 UNQ2549/PRO6175 Homo sapiens (Human) TR18426_c1_g1_i1 P55245 EGFR_MACMU 3.00E-13 GO:0005524; GO:0000139; GO:0016323; GO:0000902; GO:0008283; GO:0016337; GO:0071392; GO:0021795; GO:0003682; GO:0048546; GO:0001892; GO:0030139; GO:0005789; GO:0005768; GO:0010008; GO:0005006; GO:0001942; GO:0045121; GO:0060571; GO:0043066; GO:0042177; GO:0030235; GO:0031965; GO:0005634; GO:0048471; GO:0045739; GO:0045740; GO:0070374; GO:0043406; GO:0035413; GO:0030335; GO:0031659; GO:0050679; GO:0048146; GO:0045429; GO:0051897; GO:0001934; GO:0045944; GO:0046777; GO:0004713; GO:0050999; GO:0050730; GO:0070141; GO:0007435 ATP binding; Golgi membrane; basolateral plasma membrane; cell morphogenesis; cell proliferation; cell-cell adhesion; cellular response to estradiol stimulus; cerebral cortex cell migration; chromatin binding; digestive tract morphogenesis; embryonic placenta development; endocytic vesicle; endoplasmic reticulum membrane; endosome; endosome membrane; epidermal growth factor-activated receptor activity; hair follicle development; membrane raft; morphogenesis of an epithelial fold; negative regulation of apoptotic process; negative regulation of protein catabolic process; nitric-oxide synthase regulator activity; nuclear membrane; nucleus; perinuclear region of cytoplasm; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAP kinase activity; positive regulation of catenin import into nucleus; positive regulation of cell migration; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of nitric oxide biosynthetic process; positive regulation of protein kinase B signaling cascade; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein autophosphorylation; protein tyrosine kinase activity; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; response to UV-A; salivary gland morphogenesis IPR011009; IPR000719; IPR001245; Epidermal growth factor receptor (EC 2.7.10.1) (Fragment) EGFR Macaca mulatta (Rhesus macaque) TR18426_c2_g1_i1 P29376 LTK_HUMAN 2.00E-45 GO:0005524; GO:0008283; GO:0071300; GO:0005887; GO:0043066; GO:0014065; GO:0010666; GO:0010976; GO:0004714; GO:0007169 ATP binding; cell proliferation; cellular response to retinoic acid; integral to plasma membrane; negative regulation of apoptotic process; phosphatidylinositol 3-kinase cascade; positive regulation of cardiac muscle cell apoptotic process; positive regulation of neuron projection development; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR011009; IPR026984; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR002011; Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1) LTK TYK1 Homo sapiens (Human) TR18426_c2_g2_i1 P00543 FES_FSVST 4.00E-33 GO:0005524; GO:0004715; GO:0018108 ATP binding; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR008266; IPR020635; Tyrosine-protein kinase transforming protein Fes (EC 2.7.10.2) V-FES Feline sarcoma virus (strain Snyder-Theilen) TR18428_c0_g1_i1 A6H8I2 SGSM3_XENLA 1.00E-09 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; IPR004012; IPR001452; Small G protein signaling modulator 3 homolog (RUN and TBC1 domain-containing protein 3) sgsm3 rutbc3 Xenopus laevis (African clawed frog) TR18430_c0_g1_i1 O88828 RPAB2_RAT 4.00E-49 GO:0003677; GO:0005736; GO:0005665; GO:0005666; GO:0003899; GO:0006360; GO:0006366; GO:0006383 "DNA binding; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase activity; transcription from RNA polymerase I promoter; transcription from RNA polymerase II promoter; transcription from RNA polymerase III promoter" IPR020708; IPR006110; IPR012293; IPR028363; IPR006111; "DNA-directed RNA polymerases I, II, and III subunit RPABC2 (RNA polymerases I, II, and III subunit ABC2) (DNA-directed RNA polymerase II subunit F) (RPB6 homolog)" Polr2f Rattus norvegicus (Rat) TR18432_c0_g1_i1 Q6E2N3 TRI33_DANRE 5.00E-06 GO:0003677; GO:0016874; GO:0005634; GO:0016567; GO:0006355; GO:0006351; GO:0008270 "DNA binding; ligase activity; nucleus; protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (Protein moonshine) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 mon Danio rerio (Zebrafish) (Brachydanio rerio) TR18437_c0_g1_i1 Q86Z23 C1QL4_HUMAN 9.00E-14 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) C1QL4 CTRP11 Homo sapiens (Human) TR18441_c0_g1_i1 Q9VCA8 ANKHM_DROME 7.00E-13 GO:0003723; GO:0019730; GO:0051298; GO:0001751; GO:0005811; GO:0043066; GO:0046427; GO:0007169 RNA binding; antimicrobial humoral response; centrosome duplication; compound eye photoreceptor cell differentiation; lipid particle; negative regulation of apoptotic process; positive regulation of JAK-STAT cascade; transmembrane receptor protein tyrosine kinase signaling pathway IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) TR18441_c0_g2_i1 P16157 ANK1_HUMAN 6.00E-16 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR18445_c0_g2_i1 Q9N2V2 NAS30_CAEEL 2.00E-12 GO:0004222; GO:0006508; GO:0008270 metalloendopeptidase activity; proteolysis; zinc ion binding IPR000859; IPR024079; IPR001506; IPR006026; Zinc metalloproteinase nas-30 (EC 3.4.24.21) (Nematode astacin 30) nas-30 Y95B8A.1 Caenorhabditis elegans TR18445_c1_g1_i1 O57382 TLL2_XENLA 7.00E-16 GO:0005509; GO:0030154; GO:0005576; GO:0004222; GO:0007275; GO:0006508; GO:0008270 calcium ion binding; cell differentiation; extracellular region; metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Tolloid-like protein 2 (EC 3.4.24.-) (Metalloprotease xolloid) (Xenopus tolloid) tll2 xld Xenopus laevis (African clawed frog) TR18445_c1_g2_i1 Q9Y6L7 TLL2_HUMAN 1.00E-16 GO:0005509; GO:0030154; GO:0030198; GO:0005576; GO:0004222; GO:0007275; GO:0006508; GO:0008270 calcium ion binding; cell differentiation; extracellular matrix organization; extracellular region; metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Tolloid-like protein 2 (EC 3.4.24.-) TLL2 KIAA0932 Homo sapiens (Human) TR18449_c0_g1_i1 A2BGL3 WSCD2_DANRE 5.00E-10 GO:0016021; GO:0008146 integral to membrane; sulfotransferase activity IPR027417; IPR000863; IPR002889; IPR013994; WSC domain-containing protein 2 wscd2 si:ch211-240b21.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR18455_c0_g1_i1 Q8TEQ8 PIGO_HUMAN 7.00E-21 GO:0006501; GO:0005789; GO:0016021; GO:0016254; GO:0016740 C-terminal protein lipidation; endoplasmic reticulum membrane; integral to membrane; preassembly of GPI anchor in ER membrane; transferase activity IPR017849; IPR017850; IPR002591; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O) PIGO UNQ632/PRO1249 Homo sapiens (Human) TR18464_c0_g1_i1 Q2IBC0 MET_RHIFE 5.00E-48 GO:0005524; GO:0016021; GO:0007275; GO:0018108; GO:0004714; GO:0007169 ATP binding; integral to membrane; multicellular organismal development; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR013783; IPR014756; IPR002909; IPR011009; IPR016201; IPR002165; IPR000719; IPR017441; IPR001627; IPR001245; IPR008266; IPR020635; IPR016244; IPR015943; Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) MET Rhinolophus ferrumequinum (Greater horseshoe bat) TR18464_c1_g1_i1 P16056 MET_MOUSE 8.00E-13 GO:0005524; GO:0000187; GO:0030534; GO:0009925; GO:0007420; GO:0042593; GO:0005008; GO:0016021; GO:0001889; GO:0014812; GO:0051450; GO:0014902; GO:0001890; GO:0010828; GO:0046777; GO:0060665; GO:0060079; GO:0050804; GO:0007519 P14210; P35918 ATP binding; activation of MAPK activity; adult behavior; basal plasma membrane; brain development; glucose homeostasis; hepatocyte growth factor-activated receptor activity; integral to membrane; liver development; muscle cell migration; myoblast proliferation; myotube differentiation; placenta development; positive regulation of glucose transport; protein autophosphorylation; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; regulation of excitatory postsynaptic membrane potential; regulation of synaptic transmission; skeletal muscle tissue development IPR013783; IPR014756; IPR002909; IPR011009; IPR016201; IPR002165; IPR000719; IPR017441; IPR001627; IPR001245; IPR008266; IPR020635; IPR016244; IPR015943; Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) Met Mus musculus (Mouse) TR18469_c2_g1_i1 Q8R151 ZNFX1_MOUSE 1.00E-30 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR18469_c2_g2_i1 Q09820 RENT1_SCHPO 5.00E-07 GO:0005524; GO:0004004; GO:0003677; GO:0002184; GO:0005829; GO:0000184; GO:0008270 "ATP binding; ATP-dependent RNA helicase activity; DNA binding; cytoplasmic translational termination; cytosol; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; zinc ion binding" IPR003593; IPR014001; IPR027417; IPR018999; ATP-dependent helicase upf1 (EC 3.6.4.-) (Nonsense-mediated mRNA decay protein upf1) (Regulator of nonsense transcripts 1 homolog) (Up-frameshift suppressor 1) upf1 SPAC16C9.06c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR18471_c0_g2_i1 Q9NUV9 GIMA4_HUMAN 5.00E-15 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR18474_c0_g1_i1 Q9BZF1 OSBL8_HUMAN 4.00E-27 GO:0015485; GO:0045444; GO:0006869; GO:0010891; GO:0005543 cholesterol binding; fat cell differentiation; lipid transport; negative regulation of sequestering of triglyceride; phospholipid binding IPR000648; IPR018494; IPR011993; IPR001849; Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) OSBPL8 KIAA1451 ORP8 OSBP10 Homo sapiens (Human) TR18477_c0_g1_i1 Q7ZVQ8 NS1BB_DANRE 5.00E-38 GO:0005737; GO:0005856; GO:0005634 cytoplasm; cytoskeleton; nucleus IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Influenza virus NS1A-binding protein homolog B (NS1-BP homolog B) (NS1-binding protein homolog B) ivns1abpb Danio rerio (Zebrafish) (Brachydanio rerio) TR1848_c0_g1_i1 Q10751 ACE_CHICK 2.00E-21 GO:0004180; GO:0016021; GO:0046872; GO:0008237; GO:0008241; GO:0006508 carboxypeptidase activity; integral to membrane; metal ion binding; metallopeptidase activity; peptidyl-dipeptidase activity; proteolysis IPR001548; Angiotensin-converting enzyme (ACE) (EC 3.2.1.-) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (Fragment) ACE DCP1 Gallus gallus (Chicken) TR18482_c0_g1_i1 Q90593 GRP78_CHICK 3.00E-08 GO:0005524; GO:0008180; GO:0006983; GO:0006987; GO:0009986; GO:0042149; GO:0071353; GO:0021680; GO:0021589; GO:0034663; GO:0005788; GO:0005793; GO:0030176; GO:0030496; GO:0043066; GO:0030512; GO:0031398; GO:0051603; GO:0043022 Q8AYS8 ATP binding; COP9 signalosome; ER overload response; activation of signaling protein activity involved in unfolded protein response; cell surface; cellular response to glucose starvation; cellular response to interleukin-4; cerebellar Purkinje cell layer development; cerebellum structural organization; endoplasmic reticulum chaperone complex; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment; integral to endoplasmic reticulum membrane; midbody; negative regulation of apoptotic process; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of protein ubiquitination; proteolysis involved in cellular protein catabolic process; ribosome binding IPR018181; IPR013126; 78 kDa glucose-regulated protein (GRP-78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP) HSPA5 GRP78 Gallus gallus (Chicken) TR18482_c0_g1_i2 Q5TZF3 ANR45_HUMAN 3.00E-41 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 45 ANKRD45 Homo sapiens (Human) TR18484_c0_g1_i1 Q5R931 RL10_PONAB 1.00E-127 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001197; IPR016180; IPR018255; 60S ribosomal protein L10 RPL10 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR18487_c3_g1_i1 Q5RCJ4 D19L3_PONAB 1.00E-13 GO:0016021; GO:0016757 "integral to membrane; transferase activity, transferring glycosyl groups" IPR018732; Probable C-mannosyltransferase DPY19L3 (EC 2.4.1.-) (Dpy-19-like protein 3) (Protein dpy-19 homolog 3) DPY19L3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR18490_c0_g1_i1 P79781 RS27A_CHICK 2.00E-48 GO:0002755; GO:0035419; GO:0007250; GO:0022627; GO:0045087; GO:0046872; GO:0005654; GO:0003735; GO:0035681; GO:0034134; GO:0035682; GO:0034138; GO:0034142; GO:0034146; GO:0034154; GO:0006412; GO:0019985 MyD88-dependent toll-like receptor signaling pathway; activation of MAPK activity involved in innate immune response; activation of NF-kappaB-inducing kinase activity; cytosolic small ribosomal subunit; innate immune response; metal ion binding; nucleoplasm; structural constituent of ribosome; toll-like receptor 15 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 21 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 7 signaling pathway; translation; translesion synthesis IPR002906; IPR011332; IPR019956; IPR019954; IPR000626; Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a] RPS27A UBA80 Gallus gallus (Chicken) TR18490_c1_g2_i1 A6US53 RS27A_METVS 8.00E-06 GO:0005840; GO:0003735; GO:0006412; GO:0008270 ribosome; structural constituent of ribosome; translation; zinc ion binding IPR002906; IPR022845; IPR011332; 30S ribosomal protein S27ae rps27ae Mevan_1429 Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224) TR18496_c3_g1_i1 O01705 EXT2_CAEEL 9.00E-08 GO:0048598; GO:0050508; GO:0001888; GO:0042328; GO:0015012; GO:0016021; GO:0031227; GO:0060465 embryonic morphogenesis; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; heparan sulfate N-acetylglucosaminyltransferase activity; heparan sulfate proteoglycan biosynthetic process; integral to membrane; intrinsic to endoplasmic reticulum membrane; pharynx development IPR027674; IPR004263; IPR015338; Glycan metabolism; heparan sulfate biosynthesis. Exostosin-2 (EC 2.4.1.223) (EC 2.4.1.224) (Glucuronyl-galactosyl-proteoglycan/Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses homolog 2) rib-2 K01G5.6 Caenorhabditis elegans TR18498_c3_g1_i1 Q5MJS3 DMP4_MOUSE 1.00E-118 GO:0005509; GO:0097187; GO:0070166; GO:0005615; GO:0071895; GO:0036179; GO:0030501; GO:0045669; GO:0004674; GO:0040036; GO:0051174; GO:0001501 calcium ion binding; dentinogenesis; enamel mineralization; extracellular space; odontoblast differentiation; osteoclast maturation; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; protein serine/threonine kinase activity; regulation of fibroblast growth factor receptor signaling pathway; regulation of phosphorus metabolic process; skeletal system development IPR009581; IPR024869; Extracellular serine/threonine protein kinase FAM20C (EC 2.7.11.1) (Dentin matrix protein 4) (DMP-4) (Golgi-enriched fraction casein kinase) (GEF-CK) Fam20c Dmp4 Kiaa4081 Mus musculus (Mouse) TR18502_c0_g1_i1 Q5U4U6 T23O_XENLA 4.00E-40 GO:0020037; GO:0046872; GO:0004833; GO:0019441 "heme binding; metal ion binding; tryptophan 2,3-dioxygenase activity; tryptophan catabolic process to kynurenine" IPR004981; Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. "Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)" tdo2 Xenopus laevis (African clawed frog) TR18502_c1_g1_i1 Q17P71 T23O_AEDAE 1.00E-31 GO:0020037; GO:0046872; GO:0004833; GO:0019441 "heme binding; metal ion binding; tryptophan 2,3-dioxygenase activity; tryptophan catabolic process to kynurenine" IPR004981; Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. "Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)" AAEL000428 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR18503_c0_g1_i1 Q14152 EIF3A_HUMAN 7.00E-09 GO:0005829; GO:0016282; GO:0033290; GO:0005852; GO:0001732; GO:0001731; GO:0005730; GO:0006446; GO:0005198; GO:0003743 P55884; P08729; Q9Q2G4; Q92900-2 cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation initiation complex; formation of translation preinitiation complex; nucleolus; regulation of translational initiation; structural molecule activity; translation initiation factor activity IPR027512; IPR000717; Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) EIF3A EIF3S10 KIAA0139 Homo sapiens (Human) TR18503_c0_g1_i3 Q14152 EIF3A_HUMAN 4.00E-07 GO:0005829; GO:0016282; GO:0033290; GO:0005852; GO:0001732; GO:0001731; GO:0005730; GO:0006446; GO:0005198; GO:0003743 P55884; P08729; Q9Q2G4; Q92900-2 cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation initiation complex; formation of translation preinitiation complex; nucleolus; regulation of translational initiation; structural molecule activity; translation initiation factor activity IPR027512; IPR000717; Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) EIF3A EIF3S10 KIAA0139 Homo sapiens (Human) TR18504_c3_g1_i1 P16157 ANK1_HUMAN 2.00E-32 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR18506_c0_g1_i1 Q04833 LRP_CAEEL 3.00E-08 GO:0016324; GO:0005509; GO:0005905; GO:0042395; GO:0030139; GO:0006897; GO:0016021; GO:0002119; GO:0040017; GO:0040018; GO:0030334; GO:0015248 "apical plasma membrane; calcium ion binding; coated pit; ecdysis, collagen and cuticulin-based cuticle; endocytic vesicle; endocytosis; integral to membrane; nematode larval development; positive regulation of locomotion; positive regulation of multicellular organism growth; regulation of cell migration; sterol transporter activity" IPR011042; IPR000742; IPR001881; IPR013032; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein (LRP) lrp-1 F29D11.1 Caenorhabditis elegans TR18513_c2_g1_i1 Q2TAM9 TUSC1_HUMAN 2.00E-06 Tumor suppressor candidate gene 1 protein (TSG-9) (TSG9) TUSC1 Homo sapiens (Human) TR18513_c3_g1_i1 A8WG43 CCD89_DANRE 1.00E-22 GO:0005737; GO:0005634 cytoplasm; nucleus Coiled-coil domain-containing protein 89 (Bc8 orange-interacting protein) ccdc89 boip zgc:172182 Danio rerio (Zebrafish) (Brachydanio rerio) TR18515_c1_g1_i1 Q94511 NDUS1_DROME 4.00E-36 GO:0051537; GO:0051539; GO:0042773; GO:0008137; GO:0045333; GO:0009055; GO:0046872; GO:0005747 "2 iron, 2 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; ATP synthesis coupled electron transport; NADH dehydrogenase (ubiquinone) activity; cellular respiration; electron carrier activity; metal ion binding; mitochondrial respiratory chain complex I" IPR001041; IPR012675; IPR006656; IPR000283; IPR010228; IPR019574; IPR015405; "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-75kD) (CI-75kD)" ND75 CG2286 Drosophila melanogaster (Fruit fly) TR18515_c1_g2_i1 P86203 NDUS1_MESAU 1.00E-11 GO:0051537; GO:0051539; GO:0008137; GO:0046872; GO:0005743; GO:0070469 "2 iron, 2 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; mitochondrial inner membrane; respiratory chain" "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-75kD) (CI-75kD) (Fragments)" NDUFS1 Mesocricetus auratus (Golden hamster) TR18515_c1_g3_i1 Q66HF1 NDUS1_RAT 3.00E-57 GO:0051537; GO:0051539; GO:0046034; GO:0042773; GO:0008137; GO:0008637; GO:0045333; GO:0009055; GO:0046872; GO:0005758; GO:0005747; GO:0072593; GO:0051881 "2 iron, 2 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; ATP metabolic process; ATP synthesis coupled electron transport; NADH dehydrogenase (ubiquinone) activity; apoptotic mitochondrial changes; cellular respiration; electron carrier activity; metal ion binding; mitochondrial intermembrane space; mitochondrial respiratory chain complex I; reactive oxygen species metabolic process; regulation of mitochondrial membrane potential" IPR001041; IPR012675; IPR006656; IPR000283; IPR010228; IPR019574; IPR015405; "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3)" Ndufs1 Rattus norvegicus (Rat) TR18517_c1_g2_i1 Q8C008 DZAN1_MOUSE 3.00E-28 GO:0008270 zinc ion binding IPR002110; IPR020683; IPR025874; IPR001876; Double zinc ribbon and ankyrin repeat-containing protein 1 Dzank1 Mus musculus (Mouse) TR18520_c0_g1_i1 Q9ULJ7 ANR50_HUMAN 8.00E-28 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) TR18520_c0_g2_i1 Q5UPB9 YL042_MIMIV 1.00E-13 IPR002110; IPR020683; Putative ankyrin repeat protein L42 MIMI_L42 Acanthamoeba polyphaga mimivirus (APMV) TR18527_c0_g1_i1 Q53532 SAV1_STRVL 2.00E-07 GO:0005576 extracellular region IPR005469; IPR017889; IPR005468; Streptavidin-V1 (SA V1) Streptomyces violaceus (Streptomyces venezuelae) TR18536_c1_g1_i1 Q8TDJ6 DMXL2_HUMAN 2.00E-96 GO:0017137; GO:0030054; GO:0008021; GO:0030672 Rab GTPase binding; cell junction; synaptic vesicle; synaptic vesicle membrane IPR022033; IPR015943; IPR001680; IPR017986; DmX-like protein 2 (Rabconnectin-3) DMXL2 KIAA0856 Homo sapiens (Human) TR18537_c0_g1_i1 E1C3P4 CBPC1_CHICK 1.00E-43 GO:0015991; GO:0035609; GO:0021702; GO:0005829; GO:0001754; GO:0004181; GO:0005739; GO:0007005; GO:0050905; GO:0021772; GO:0035610; GO:0006508; GO:0046961; GO:0015631; GO:0000221; GO:0008270 "ATP hydrolysis coupled proton transport; C-terminal protein deglutamylation; cerebellar Purkinje cell differentiation; cytosol; eye photoreceptor cell differentiation; metallocarboxypeptidase activity; mitochondrion; mitochondrion organization; neuromuscular process; olfactory bulb development; protein side chain deglutamylation; proteolysis; proton-transporting ATPase activity, rotational mechanism; tubulin binding; vacuolar proton-transporting V-type ATPase, V1 domain; zinc ion binding" IPR016024; IPR004908; IPR000834; Cytosolic carboxypeptidase 1 (EC 3.4.17.-) (ATP/GTP-binding protein 1) AGTPBP1 CCP1K Gallus gallus (Chicken) TR18542_c1_g1_i1 O75592 MYCB2_HUMAN 6.00E-23 GO:0030424; GO:0021785; GO:0021952; GO:0015630; GO:0005634; GO:0051493; GO:0032880; GO:0006355; GO:0006351; GO:0004842; GO:0008270 Q99IB8 "axon; branchiomotor neuron axon guidance; central nervous system projection neuron axonogenesis; microtubule cytoskeleton; nucleus; regulation of cytoskeleton organization; regulation of protein localization; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR004939; IPR017868; IPR008979; IPR027047; IPR013783; IPR014756; IPR012983; IPR009091; IPR000408; IPR003646; IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc) MYCBP2 KIAA0916 PAM Homo sapiens (Human) TR18544_c0_g1_i1 Q20655 14332_CAEEL 2.00E-94 GO:0005737; GO:0005634 G5EC23; Q11184; Q21921 cytoplasm; nucleus IPR000308; IPR023409; IPR023410; 14-3-3-like protein 2 ftt-2 F52D10.3 Caenorhabditis elegans TR18548_c0_g1_i1 P83425 HIP_MYTED 5.00E-08 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR18551_c0_g1_i1 P62250 RS16_RAT 7.00E-83 GO:0003723; GO:0022627; GO:0006364; GO:0042274; GO:0003735; GO:0006412 RNA binding; cytosolic small ribosomal subunit; rRNA processing; ribosomal small subunit biogenesis; structural constituent of ribosome; translation IPR020568; IPR014721; IPR000754; IPR020574; 40S ribosomal protein S16 Rps16 Rattus norvegicus (Rat) TR18558_c1_g1_i1 Q9VZM5 PIGB_DROME 1.00E-25 GO:0006506; GO:0005789; GO:0016021; GO:0000030 GPI anchor biosynthetic process; endoplasmic reticulum membrane; integral to membrane; mannosyltransferase activity IPR005599; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. GPI mannosyltransferase 3 (EC 2.4.1.-) (GPI mannosyltransferase III) (GPI-MT-III) CG12006 Drosophila melanogaster (Fruit fly) TR18561_c0_g1_i1 Q7YW31 CTR1_OCTVU 3.00E-08 GO:0016021; GO:0005886; GO:0016500; GO:0005000 integral to membrane; plasma membrane; protein-hormone receptor activity; vasopressin receptor activity IPR000276; IPR017452; IPR001817; Cephalotocin receptor 1 (OC/CE-R 1) (OT/VP superfamily peptide receptor 1) CTR1 Octopus vulgaris (Common octopus) TR18565_c0_g1_i1 Q3UQ41 TM11A_MOUSE 3.00E-06 GO:0007049; GO:0005576; GO:0005887; GO:0006508; GO:0004252 cell cycle; extracellular region; integral to plasma membrane; proteolysis; serine-type endopeptidase activity IPR017329; IPR001254; IPR018114; IPR001314; IPR000082; IPR009003; Transmembrane protease serine 11A (EC 3.4.21.-) (Airway trypsin-like protease 1) (Serine protease DESC3) (DESC-3) Tmprss11a Desc3 Gm7 Hatl1 Mus musculus (Mouse) TR18568_c0_g2_i1 Q58DL5 BCAR3_BOVIN 8.00E-16 GO:0005085; GO:0005622; GO:0007264 guanyl-nucleotide exchange factor activity; intracellular; small GTPase mediated signal transduction IPR023578; IPR001895; IPR000980; Breast cancer anti-estrogen resistance protein 3 BCAR3 Bos taurus (Bovine) TR18575_c1_g1_i1 Q4KM79 DUS11_RAT 7.00E-35 GO:0003723; GO:0005634; GO:0035335; GO:0004725; GO:0008138 RNA binding; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR000387; IPR016130; RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Dual specificity protein phosphatase 11) (Phosphatase that interacts with RNA/RNP complex 1) Dusp11 Pir1 Rattus norvegicus (Rat) TR1858_c0_g1_i1 Q6ZTY8 CL063_HUMAN 7.00E-10 Putative uncharacterized protein C12orf63 C12orf63 Homo sapiens (Human) TR18580_c0_g1_i1 Q5EA64 COCH_BOVIN 3.00E-09 GO:0005615; GO:0008360 extracellular space; regulation of cell shape IPR004043; IPR002035; Cochlin COCH Bos taurus (Bovine) TR18585_c0_g1_i1 Q9JIM3 RAD26_MOUSE 5.00E-35 GO:0005524; GO:0008026; GO:0003677; GO:0006281; GO:0005737; GO:0005815; GO:0005634 ATP binding; ATP-dependent helicase activity; DNA binding; DNA repair; cytoplasm; microtubule organizing center; nucleus IPR002464; IPR014001; IPR001650; IPR027417; IPR000330; Putative DNA repair and recombination protein RAD26-like (EC 3.6.4.-) Rad26l Mus musculus (Mouse) TR18585_c1_g1_i1 Q99NG0 ARIP4_MOUSE 1.00E-11 GO:0005524; GO:0003677; GO:0004386; GO:0005634; GO:0003712 ATP binding; DNA binding; helicase activity; nucleus; transcription cofactor activity IPR014001; IPR001650; IPR027417; IPR000330; Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) (Steroid receptor-interacting SNF2 domain-containing protein-like) Rad54l2 Arip4 Srisnf2l Mus musculus (Mouse) TR18591_c1_g1_i1 Q9QW30 NOTC2_RAT 9.00E-06 GO:0007219; GO:0005509; GO:0007050; GO:0001709; GO:0016049; GO:0009986; GO:0005829; GO:0005576; GO:0005887; GO:0008285; GO:0005634; GO:0009887; GO:0046579; GO:0004872; GO:0050793; GO:0006355; GO:0042246; GO:0006351 "Notch signaling pathway; calcium ion binding; cell cycle arrest; cell fate determination; cell growth; cell surface; cytosol; extracellular region; integral to plasma membrane; negative regulation of cell proliferation; nucleus; organ morphogenesis; positive regulation of Ras protein signal transduction; receptor activity; regulation of developmental process; regulation of transcription, DNA-dependent; tissue regeneration; transcription, DNA-dependent" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022336; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 2 (Notch 2) [Cleaved into: Notch 2 extracellular truncation; Notch 2 intracellular domain] Notch2 Rattus norvegicus (Rat) TR18592_c2_g1_i1 P12798 KPBB_RABIT 2.00E-49 GO:0005977; GO:0004553; GO:0005886 "glycogen metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; plasma membrane" IPR008928; IPR011613; IPR008734; Glycan biosynthesis; glycogen metabolism. Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta) PHKB Oryctolagus cuniculus (Rabbit) TR18594_c0_g1_i1 O88563 MRP3_RAT 9.00E-06 GO:0005524; GO:0016323; GO:0015432; GO:0015722; GO:0016021; GO:0032355; GO:0032496; GO:0010243; GO:0008559 ATP binding; basolateral plasma membrane; bile acid-exporting ATPase activity; canalicular bile acid transport; integral to membrane; response to estradiol stimulus; response to lipopolysaccharide; response to organonitrogen compound; xenobiotic-transporting ATPase activity IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (MRP-like protein 2) (MLP-2) (Multidrug resistance-associated protein 3) Abcc3 Cmoat2 Mlp2 Mrp3 Rattus norvegicus (Rat) TR18595_c0_g1_i1 Q9UPU7 TBD2B_HUMAN 1.00E-11 GO:0005097; GO:0005543; GO:0032851 O95166; Q9H0R8; P60520; Q9GZQ8; Q9BXW4 Rab GTPase activator activity; phospholipid binding; positive regulation of Rab GTPase activity IPR011993; IPR001849; IPR000195; TBC1 domain family member 2B TBC1D2B KIAA1055 Homo sapiens (Human) TR18599_c0_g1_i1 O15943 CADN_DROME 1.00E-20 GO:0045467; GO:0045463; GO:0030424; GO:0048846; GO:0007412; GO:0007413; GO:0008013; GO:0005509; GO:0016339; GO:0050839; GO:0044331; GO:0005911; GO:0030425; GO:0007156; GO:0005887; GO:0050774; GO:0016318; GO:0004872; GO:0048841; GO:0031290 R7 cell development; R8 cell development; axon; axon extension involved in axon guidance; axon target recognition; axonal fasciculation; beta-catenin binding; calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; cell-cell adhesion mediated by cadherin; cell-cell junction; dendrite; homophilic cell adhesion; integral to plasma membrane; negative regulation of dendrite morphogenesis; ommatidial rotation; receptor activity; regulation of axon extension involved in axon guidance; retinal ganglion cell axon guidance IPR002126; IPR015919; IPR020894; IPR000233; IPR027397; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR009030; IPR001791; Neural-cadherin (Cadherin-N) (dN-cadherin) CadN CG7100 Drosophila melanogaster (Fruit fly) TR18604_c1_g1_i1 D3ZG52 DNA2_RAT 5.00E-62 GO:0051539; GO:0043139; GO:0017108; GO:0005524; GO:0003677; GO:0000729; GO:0000076; GO:0033567; GO:0043137; GO:0006284; GO:0005760; GO:0046872; GO:0043504; GO:0006264; GO:0042645; GO:0005634; GO:0045740; GO:0043142; GO:0016890 "4 iron, 4 sulfur cluster binding; 5'-3' DNA helicase activity; 5'-flap endonuclease activity; ATP binding; DNA binding; DNA double-strand break processing; DNA replication checkpoint; DNA replication, Okazaki fragment processing; DNA replication, removal of RNA primer; base-excision repair; gamma DNA polymerase complex; metal ion binding; mitochondrial DNA repair; mitochondrial DNA replication; mitochondrial nucleoid; nucleus; positive regulation of DNA replication; single-stranded DNA-dependent ATPase activity; site-specific endodeoxyribonuclease activity, specific for altered base" IPR026851; IPR014808; IPR027417; DNA replication ATP-dependent helicase/nuclease DNA2 (DNA replication ATP-dependent helicase-like homolog) [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent helicase DNA2 (EC 3.6.4.12)] Dna2 Rattus norvegicus (Rat) TR18615_c0_g1_i1 Q8R4V5 OIT3_MOUSE 6.00E-07 GO:0005635 nuclear envelope IPR000742; IPR001507; Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein) Oit3 Lzp Mus musculus (Mouse) TR18619_c0_g1_i1 F7AEX0 UVSSA_XENTR 3.00E-68 GO:0000993; GO:0005694; GO:0016567; GO:0009411; GO:0006283 RNA polymerase II core binding; chromosome; protein ubiquitination; response to UV; transcription-coupled nucleotide-excision repair IPR018610; UV-stimulated scaffold protein A uvssa Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR18623_c0_g1_i1 P0DKB4 T3HPD_SACKO 3.00E-17 GO:0016836; GO:0050346 hydro-lyase activity; trans-L-3-hydroxyproline dehydratase activity IPR008794; Trans-L-3-hydroxyproline dehydratase (EC 4.2.1.77) (Trans-3-hydroxy-l-proline dehydratase) l3hypdh Saccoglossus kowalevskii (Acorn worm) TR18630_c1_g1_i1 Q6P3R8 NEK5_HUMAN 1.00E-58 GO:0005524; GO:0046872; GO:0004674 ATP binding; metal ion binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase Nek5 (EC 2.7.11.1) (Never in mitosis A-related kinase 5) (NimA-related protein kinase 5) NEK5 Homo sapiens (Human) TR18630_c1_g1_i2 Q55GU0 Y9955_DICDI 1.00E-24 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR001245; IPR002290; IPR008271; Probable serine/threonine-protein kinase DDB_G0267514 (EC 2.7.11.1) DDB_G0267514 Dictyostelium discoideum (Slime mold) TR18637_c0_g2_i1 Q9P0L9 PK2L1_HUMAN 2.00E-11 GO:0005262; GO:0005509; GO:0015269; GO:0009986; GO:0071468; GO:0001581; GO:0050982; GO:0005783; GO:0042802; GO:0016021; GO:0005886; GO:0005272; GO:0033040 calcium channel activity; calcium ion binding; calcium-activated potassium channel activity; cell surface; cellular response to acidity; detection of chemical stimulus involved in sensory perception of sour taste; detection of mechanical stimulus; endoplasmic reticulum; identical protein binding; integral to membrane; plasma membrane; sodium channel activity; sour taste receptor activity IPR011992; IPR013122; IPR003915; Polycystic kidney disease 2-like 1 protein (Polycystin-2 homolog) (Polycystin-2L1) (Polycystin-L) (Polycystin-L1) PKD2L1 PKD2L PKDL Homo sapiens (Human) TR18643_c0_g1_i1 Q96NL6 SCLT1_HUMAN 1.00E-12 GO:0005814; GO:0042384; GO:0071439; GO:0045162; GO:0045111; GO:0017080 centriole; cilium assembly; clathrin complex; clustering of voltage-gated sodium channels; intermediate filament cytoskeleton; sodium channel regulator activity Sodium channel and clathrin linker 1 (Sodium channel-associated protein 1) SCLT1 SAP1 Homo sapiens (Human) TR18649_c1_g1_i1 Q9D7P6 ISCU_MOUSE 3.00E-41 GO:0005829; GO:0005506; GO:0016226; GO:0051536; GO:0005739 cytosol; iron ion binding; iron-sulfur cluster assembly; iron-sulfur cluster binding; mitochondrion IPR011339; IPR002871; "Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (NifU-like N-terminal domain-containing protein) (NifU-like protein)" Iscu Nifun Mus musculus (Mouse) TR18651_c0_g1_i1 F6RIX4 MCM9_XENTR 4.00E-14 GO:0005524; GO:0003677; GO:0006260; GO:0097362; GO:0000724; GO:0004386; GO:0005634 ATP binding; DNA binding; DNA replication; MCM8-MCM9 complex; double-strand break repair via homologous recombination; helicase activity; nucleus IPR003593; IPR001208; IPR012340; IPR027417; DNA helicase MCM9 (EC 3.6.4.12) (Minichromosome maintenance 9) mcm9 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR18654_c1_g1_i1 P35448 TSP1_XENLA 5.00E-27 GO:0005509; GO:0007155; GO:0005576; GO:0008201; GO:0016529 calcium ion binding; cell adhesion; extracellular region; heparin binding; sarcoplasmic reticulum IPR026823; IPR008985; IPR013320; IPR000742; IPR013032; IPR024731; IPR001791; IPR000884; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-1 thbs1 tsp1 Xenopus laevis (African clawed frog) TR18654_c2_g1_i1 P57110 ATS8_MOUSE 6.00E-13 GO:0008201; GO:0004222; GO:0005578; GO:0006508; GO:0008270 heparin binding; metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR013277; IPR001590; IPR013273; IPR002870; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAM-TS 8) (ADAM-TS8) (ADAMTS-8) (EC 3.4.24.-) (METH-2) Adamts8 Mus musculus (Mouse) TR18657_c1_g2_i1 Q9FY48 KEG_ARATH 7.00E-07 GO:0005524; GO:0005794; GO:0009738; GO:0006952; GO:0048589; GO:0005769; GO:0016197; GO:0009788; GO:0004672; GO:0004674; GO:0032940; GO:0005802; GO:0004842; GO:0008270 Q9SJN0 ATP binding; Golgi apparatus; abscisic acid mediated signaling pathway; defense response; developmental growth; early endosome; endosomal transport; negative regulation of abscisic acid mediated signaling pathway; protein kinase activity; protein serine/threonine kinase activity; secretion by cell; trans-Golgi network; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR011009; IPR000719; IPR027370; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase KEG (EC 2.7.11.1) (EC 6.3.2.-) (Protein KEEP ON GOING) (RING finger protein KEG) KEG At5g13530 T6I14.60 T6I14.70 Arabidopsis thaliana (Mouse-ear cress) TR18659_c0_g1_i1 P13611 CSPG2_HUMAN 4.00E-17 GO:0005796; GO:0005509; GO:0030246; GO:0005975; GO:0007155; GO:0008037; GO:0030206; GO:0030207; GO:0030208; GO:0030198; GO:0005615; GO:0008347; GO:0007507; GO:0005540; GO:0043202; GO:0007275; GO:0005578 P14780 Golgi lumen; calcium ion binding; carbohydrate binding; carbohydrate metabolic process; cell adhesion; cell recognition; chondroitin sulfate biosynthetic process; chondroitin sulfate catabolic process; dermatan sulfate biosynthetic process; extracellular matrix organization; extracellular space; glial cell migration; heart development; hyaluronic acid binding; lysosomal lumen; multicellular organismal development; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Homo sapiens (Human) TR18665_c0_g1_i2 Q5F356 PI42A_CHICK 8.00E-133 GO:0016309; GO:0005524; GO:0005737; GO:0005634; GO:0046854; GO:0005886 1-phosphatidylinositol-5-phosphate 4-kinase activity; ATP binding; cytoplasm; nucleus; phosphatidylinositol phosphorylation; plasma membrane IPR023610; IPR027483; IPR002498; IPR027484; IPR016034; Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(5)P-4-kinase isoform 2-alpha) PIP4K2A PIP5K2A RCJMB04_33l24 Gallus gallus (Chicken) TR18673_c0_g1_i1 B3A0Q8 PLSP2_LOTGI 2.00E-36 GO:0005576; GO:0020037; GO:0004601; GO:0006979 extracellular region; heme binding; peroxidase activity; response to oxidative stress IPR010255; IPR002007; IPR019791; Peroxidase-like protein 3 (Fragment) Lottia gigantea (Giant owl limpet) TR18693_c0_g1_i1 Q24799 MYPH_ECHGR 1.00E-24 IPR000557; IPR001715; IPR003096; Myophilin Echinococcus granulosus TR18694_c0_g1_i1 Q9CR61 NDUB7_MOUSE 5.00E-16 GO:0008137; GO:0005743; GO:0005758; GO:0005747 NADH dehydrogenase (ubiquinone) activity; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial respiratory chain complex I IPR008698; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (Complex I-B18) (CI-B18) (NADH-ubiquinone oxidoreductase B18 subunit) Ndufb7 Mus musculus (Mouse) TR18703_c1_g1_i1 P95607 CATA_RHOOP 2.00E-07 GO:0019439; GO:0018576; GO:0009712; GO:0008199 "aromatic compound catabolic process; catechol 1,2-dioxygenase activity; catechol-containing compound metabolic process; ferric iron binding" IPR007535; IPR012800; IPR000627; IPR015889; "Catechol 1,2-dioxygenase (EC 1.13.11.1) (1,2-CTD) (Fragment)" catA Rhodococcus opacus (Nocardia opaca) TR18703_c3_g1_i1 O67987 CLCA_RHOOP 6.00E-07 GO:0019439; GO:0018576; GO:0009712; GO:0018575; GO:0008199 "aromatic compound catabolic process; catechol 1,2-dioxygenase activity; catechol-containing compound metabolic process; chlorocatechol 1,2-dioxygenase activity; ferric iron binding" IPR007535; IPR012817; IPR000627; IPR015889; "Chlorocatechol 1,2-dioxygenase (EC 1.13.11.-)" clcA Rhodococcus opacus (Nocardia opaca) TR1871_c0_g1_i1 Q9QUG2 POLK_MOUSE 1.00E-30 GO:0006281; GO:0006260; GO:0003887; GO:0003684; GO:0046872; GO:0006297; GO:0005634 "DNA repair; DNA replication; DNA-directed DNA polymerase activity; damaged DNA binding; metal ion binding; nucleotide-excision repair, DNA gap filling; nucleus" IPR017961; IPR001126; IPR017963; IPR022880; IPR006642; DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP) Polk Dinb1 Mus musculus (Mouse) TR18711_c0_g2_i1 Q8NCW0 KREM2_HUMAN 2.00E-10 GO:0016055; GO:0016021 Wnt receptor signaling pathway; integral to membrane IPR000859; IPR017076; IPR000001; IPR013806; IPR018056; IPR002889; Kremen protein 2 (Dickkopf receptor 2) (Kringle domain-containing transmembrane protein 2) (Kringle-containing protein marking the eye and the nose) KREMEN2 KRM2 Homo sapiens (Human) TR18714_c2_g1_i1 Q4KLQ5 WDR76_XENLA 3.00E-17 IPR015943; IPR001680; IPR017986; WD repeat-containing protein 76 wdr76 Xenopus laevis (African clawed frog) TR18715_c1_g1_i1 Q9R1X5 MRP5_MOUSE 2.00E-08 GO:0005524; GO:0006200; GO:0042626; GO:0016021 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) Abcc5 Abcc5a Mrp5 Mus musculus (Mouse) TR18716_c2_g1_i1 A3KMX0 ER6L2_BOVIN 6.00E-08 DNA excision repair protein ERCC-6-like 2 ERCC6L2 Bos taurus (Bovine) TR18716_c3_g1_i1 Q9NEL2 SSL1_CAEEL 2.00E-20 GO:0005524; GO:0003677; GO:0016568; GO:0004386; GO:0007275; GO:0005634 ATP binding; DNA binding; chromatin modification; helicase activity; multicellular organismal development; nucleus IPR014012; IPR014001; IPR001650; IPR027417; IPR000330; Helicase ssl-1 (EC 3.6.4.-) (Swi/snf2-like protein 1) ssl-1 Y111B2A.22 Caenorhabditis elegans TR18720_c0_g1_i1 Q9UQ07 MOK_HUMAN 5.00E-35 GO:0005524; GO:0004693; GO:0005737; GO:0004674; GO:0007165 ATP binding; cyclin-dependent protein serine/threonine kinase activity; cytoplasm; protein serine/threonine kinase activity; signal transduction IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1) MOK RAGE RAGE1 Homo sapiens (Human) TR18721_c0_g1_i1 Q502G5 CA050_DANRE 1.00E-67 IPR019534; Uncharacterized protein C1orf50 homolog zgc:112255 Danio rerio (Zebrafish) (Brachydanio rerio) TR18736_c4_g1_i1 Q29BL9 LMBD2_DROPS 1.00E-32 GO:0016021 integral to membrane IPR006876; LMBR1 domain-containing protein 2 homolog GA20843 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR18737_c2_g1_i1 Q28983 ZAN_PIG 1.00E-64 GO:0007339; GO:0007155; GO:0050840; GO:0016021; GO:0005886 binding of sperm to zona pellucida; cell adhesion; extracellular matrix binding; integral to membrane; plasma membrane IPR008985; IPR000742; IPR013032; IPR000998; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; Zonadhesin ZAN Sus scrofa (Pig) TR18745_c0_g1_i1 Q8C3L1 CC032_MOUSE 5.00E-11 GO:0005737 cytoplasm IPR001305; Protein SSUH2 homolog (Protein ssu-2 homolog) Ssuh2 Ssu2 Mus musculus (Mouse) TR18745_c0_g2_i1 Q97BG9 DNAJ_THEVO 8.00E-06 GO:0005524; GO:0006260; GO:0005737; GO:0006457; GO:0009408; GO:0008270 ATP binding; DNA replication; cytoplasm; protein folding; response to heat; zinc ion binding IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; Chaperone protein DnaJ dnaJ TV0486 TVG0470348 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) TR18747_c0_g1_i1 Q9Y2I9 TBC30_HUMAN 8.00E-08 GO:0005097; GO:0005886; GO:0032851 Rab GTPase activator activity; plasma membrane; positive regulation of Rab GTPase activity IPR000195; TBC1 domain family member 30 TBC1D30 KIAA0984 Homo sapiens (Human) TR18747_c1_g2_i1 Q6PBU5 GRT1A_DANRE 3.00E-65 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; Growth hormone-regulated TBC protein 1-A grtp1a grtp1 Danio rerio (Zebrafish) (Brachydanio rerio) TR18747_c1_g3_i1 Q4QQU7 GRTP1_RAT 2.00E-27 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; Growth hormone-regulated TBC protein 1 Grtp1 Rattus norvegicus (Rat) TR18749_c0_g1_i1 P56558 OGT1_RAT 8.00E-09 GO:0006915; GO:0005829; GO:0080182; GO:0043984; GO:0043981; GO:0043982; GO:0000123; GO:0048029; GO:0042277; GO:0005547; GO:0048015; GO:0005886; GO:0045862; GO:0045944; GO:0016262; GO:0006493; GO:0070207; GO:0006110 Q9WVH3 "apoptotic process; cytosol; histone H3-K4 trimethylation; histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase complex; monosaccharide binding; peptide binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-mediated signaling; plasma membrane; positive regulation of proteolysis; positive regulation of transcription from RNA polymerase II promoter; protein N-acetylglucosaminyltransferase activity; protein O-linked glycosylation; protein homotrimerization; regulation of glycolysis" IPR013026; IPR011990; IPR001440; IPR019734; Protein modification; protein glycosylation. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) Ogt Rattus norvegicus (Rat) TR18749_c0_g2_i1 Q86TZ1 TTC6_HUMAN 4.00E-61 IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 6 (TPR repeat protein 6) TTC6 Homo sapiens (Human) TR18749_c1_g1_i1 Q86TZ1 TTC6_HUMAN 3.00E-28 IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 6 (TPR repeat protein 6) TTC6 Homo sapiens (Human) TR18756_c0_g1_i1 Q8K1S4 UNC5A_MOUSE 2.00E-09 GO:0033564; GO:0006915; GO:0005829; GO:0016021; GO:0005886; GO:0007165 anterior/posterior axon guidance; apoptotic process; cytosol; integral to membrane; plasma membrane; signal transduction IPR011029; IPR000488; IPR007110; IPR013783; IPR013098; IPR003599; IPR000884; IPR000906; Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A) Unc5a Kiaa1976 Unc5h1 Mus musculus (Mouse) TR18760_c0_g1_i1 Q3TWN3 CNNM2_MOUSE 5.00E-54 GO:0030554; GO:0016323; GO:0016021; GO:0010960; GO:0015693 adenyl nucleotide binding; basolateral plasma membrane; integral to membrane; magnesium ion homeostasis; magnesium ion transport IPR000644; IPR002550; IPR014710; Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (mACDP2) (Cyclin-M2) Cnnm2 Acdp2 Mus musculus (Mouse) TR18760_c2_g1_i1 Q8NE01 CNNM3_HUMAN 3.00E-18 GO:0030554; GO:0016021; GO:0006811; GO:0005886 Q99750 adenyl nucleotide binding; integral to membrane; ion transport; plasma membrane IPR000644; IPR002550; Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3) CNNM3 ACDP3 Homo sapiens (Human) TR18760_c3_g1_i1 Q3TWN3 CNNM2_MOUSE 4.00E-56 GO:0030554; GO:0016323; GO:0016021; GO:0010960; GO:0015693 adenyl nucleotide binding; basolateral plasma membrane; integral to membrane; magnesium ion homeostasis; magnesium ion transport IPR000644; IPR002550; IPR014710; Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (mACDP2) (Cyclin-M2) Cnnm2 Acdp2 Mus musculus (Mouse) TR18767_c0_g1_i1 Q9QUN7 TLR2_MOUSE 6.00E-10 GO:0002755; GO:0035354; GO:0035355; GO:0002752; GO:0071221; GO:0071223; GO:0071224; GO:0042892; GO:0050830; GO:0042498; GO:0009897; GO:0052063; GO:0006954; GO:0045087; GO:0016021; GO:0070891; GO:0044130; GO:0032695; GO:0032700; GO:0030670; GO:0032722; GO:0050715; GO:0050729; GO:0032728; GO:0032735; GO:0032741; GO:0032755; GO:0002687; GO:0060907; GO:0045429; GO:0051770; GO:0045944; GO:0042535; GO:0032760; GO:0046982; GO:0002238; GO:0034134; GO:0004888; GO:0042497 MyD88-dependent toll-like receptor signaling pathway; Toll-like receptor 1-Toll-like receptor 2 protein complex; Toll-like receptor 2-Toll-like receptor 6 protein complex; cell surface pattern recognition receptor signaling pathway; cellular response to bacterial lipopeptide; cellular response to lipoteichoic acid; cellular response to peptidoglycan; chloramphenicol transport; defense response to Gram-positive bacterium; diacyl lipopeptide binding; external side of plasma membrane; induction by symbiont of defense-related host nitric oxide production; inflammatory response; innate immune response; integral to membrane; lipoteichoic acid binding; negative regulation of growth of symbiont in host; negative regulation of interleukin-12 production; negative regulation of interleukin-17 production; phagocytic vesicle membrane; positive regulation of chemokine production; positive regulation of cytokine secretion; positive regulation of inflammatory response; positive regulation of interferon-beta production; positive regulation of interleukin-12 production; positive regulation of interleukin-18 production; positive regulation of interleukin-6 production; positive regulation of leukocyte migration; positive regulation of macrophage cytokine production; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of tumor necrosis factor production; protein heterodimerization activity; response to molecule of fungal origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity; triacyl lipopeptide binding IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) Tlr2 Mus musculus (Mouse) TR18771_c5_g1_i1 Q9JLC8 SACS_MOUSE 4.00E-14 GO:0005524; GO:0050750; GO:0005739; GO:0090084; GO:0005634 ATP binding; low-density lipoprotein particle receptor binding; mitochondrion; negative regulation of inclusion body assembly; nucleus IPR001623; IPR003594; IPR007842; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) TR18772_c3_g1_i1 Q4R6V2 TCPE_MACFA 5.00E-69 GO:0005524; GO:0005737; GO:0005815; GO:0006457 ATP binding; cytoplasm; microtubule organizing center; protein folding IPR012718; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon) CCT5 QtsA-17059 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR18782_c2_g1_i1 A2RU49 AGPD1_HUMAN 3.00E-31 GO:0005737; GO:0047992 cytoplasm; hydroxylysine kinase activity IPR002575; IPR011009; Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC 2.7.1.81) (Aminoglycoside phosphotransferase domain-containing protein 1) HYKK AGPHD1 Homo sapiens (Human) TR18794_c0_g1_i1 P98158 LRP2_RAT 1.00E-30 GO:0007568; GO:0016324; GO:0031526; GO:0005509; GO:0005905; GO:0016197; GO:0005768; GO:0005615; GO:0030492; GO:0020028; GO:0046879; GO:0016021; GO:0042953; GO:0045121; GO:0010951; GO:0031100; GO:0043234; GO:0004872; GO:0006898; GO:0010165; GO:0042493; GO:0032526; GO:0033280; GO:0045056; GO:0006766 O88797 aging; apical plasma membrane; brush border membrane; calcium ion binding; coated pit; endosomal transport; endosome; extracellular space; hemoglobin binding; hemoglobin import; hormone secretion; integral to membrane; lipoprotein transport; membrane raft; negative regulation of endopeptidase activity; organ regeneration; protein complex; receptor activity; receptor-mediated endocytosis; response to X-ray; response to drug; response to retinoic acid; response to vitamin D; transcytosis; vitamin metabolic process IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) Lrp2 Rattus norvegicus (Rat) TR18809_c1_g2_i1 O00560 SDCB1_HUMAN 2.00E-06 GO:0007265; GO:0030036; GO:0005912; GO:0007411; GO:0008093; GO:0005856; GO:0005829; GO:0005789; GO:0070062; GO:0005925; GO:0005137; GO:0005895; GO:0035556; GO:0042470; GO:0005634; GO:0046330; GO:0042327; GO:0006612; GO:0006930; GO:0007268; GO:0045545 Itself; O75084 "Ras protein signal transduction; actin cytoskeleton organization; adherens junction; axon guidance; cytoskeletal adaptor activity; cytoskeleton; cytosol; endoplasmic reticulum membrane; extracellular vesicular exosome; focal adhesion; interleukin-5 receptor binding; interleukin-5 receptor complex; intracellular signal transduction; melanosome; nucleus; positive regulation of JNK cascade; positive regulation of phosphorylation; protein targeting to membrane; substrate-dependent cell migration, cell extension; synaptic transmission; syndecan binding" IPR001478; Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1) SDCBP MDA9 SYCL Homo sapiens (Human) TR1881_c0_g1_i1 P51537 MYG_HALMK 1.00E-52 GO:0020037; GO:0046872; GO:0005344 heme binding; metal ion binding; oxygen transporter activity IPR000898; Myoglobin Haliotis madaka (Giant abalone) (Nordotis madaka) TR18812_c0_g1_i1 P14381 YTX2_XENLA 1.00E-14 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR18814_c0_g1_i1 A9JRD8 BTB6A_DANRE 1.00E-14 GO:0030154; GO:0000932; GO:0007399 cell differentiation; cytoplasmic mRNA processing body; nervous system development IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6-A btbd6a zgc:172197 Danio rerio (Zebrafish) (Brachydanio rerio) TR18818_c0_g1_i1 P28493 PR5_ARATH 8.00E-57 GO:0048046; GO:0005618; GO:0031540; GO:0010224; GO:0046686; GO:0009615; GO:0009627; GO:0005773 Q42403 apoplast; cell wall; regulation of anthocyanin biosynthetic process; response to UV-B; response to cadmium ion; response to virus; systemic acquired resistance; vacuole IPR001938; IPR017949; Pathogenesis-related protein 5 (PR-5) At1g75040 F9E10.11 Arabidopsis thaliana (Mouse-ear cress) TR18822_c0_g1_i1 Q39752 CALM_FAGSY 5.00E-29 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) CAMF1 CAMF-1 Fagus sylvatica (Beechnut) TR18822_c0_g2_i1 O97341 CALM_SUBDO 3.00E-33 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) Suberites domuncula (Sponge) TR18844_c0_g1_i2 Q501L1 P20D2_XENTR 4.00E-17 GO:0016787 hydrolase activity IPR017144; IPR002933; IPR011650; Peptidase M20 domain-containing protein 2 (Aminoacylase-1-like protein 2) pm20d2 acy1l2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR18847_c0_g1_i1 Q5RJK8 ACBD6_RAT 2.00E-11 GO:0005737; GO:0000062; GO:0008289; GO:0005634 cytoplasm; fatty-acyl-CoA binding; lipid binding; nucleus IPR000582; IPR002110; IPR020683; IPR014352; Acyl-CoA-binding domain-containing protein 6 Acbd6 Rattus norvegicus (Rat) TR18847_c2_g2_i1 Q8Q0U0 Y045_METMA 6.00E-11 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR18847_c3_g1_i1 Q9J4Z4 V246_FOWPN 2.00E-12 IPR002110; IPR020683; IPR018272; Putative ankyrin repeat protein FPV246 FPV246 Fowlpox virus (strain NVSL) (FPV) TR18847_c3_g1_i2 Q0VGY8 TANC1_MOUSE 6.00E-12 GO:0043679; GO:0030054; GO:0030425; GO:0097062; GO:0007520; GO:0043025; GO:0014069; GO:0045211; GO:0008542 axon terminus; cell junction; dendrite; dendritic spine maintenance; myoblast fusion; neuronal cell body; postsynaptic density; postsynaptic membrane; visual learning IPR002110; IPR020683; IPR027417; IPR013026; IPR011990; IPR013105; IPR019734; "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" Tanc1 Mus musculus (Mouse) TR18850_c0_g1_i1 Q6NS46 RRP5_MOUSE 3.00E-32 GO:0003723; GO:0006915; GO:0005829; GO:0006397; GO:0005730; GO:0043123; GO:0006364; GO:0006355 "RNA binding; apoptotic process; cytosol; mRNA processing; nucleolus; positive regulation of I-kappaB kinase/NF-kappaB cascade; rRNA processing; regulation of transcription, DNA-dependent" IPR003107; IPR012340; IPR003029; IPR022967; IPR008847; IPR013026; IPR011990; Protein RRP5 homolog (Apoptosis-linked gene 4 protein) (Programmed cell death protein 11) Pdcd11 Alg4 Kiaa0185 Mus musculus (Mouse) TR18852_c1_g1_i1 Q8TD26 CHD6_HUMAN 2.00E-25 GO:0005524; GO:0008026; GO:0003677; GO:0003682; GO:0006338; GO:0007399; GO:0005634; GO:0006355; GO:0006351 "ATP binding; ATP-dependent helicase activity; DNA binding; chromatin binding; chromatin remodeling; nervous system development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006576; IPR023780; IPR000953; IPR016197; IPR002464; IPR014001; IPR001650; IPR027417; IPR001005; IPR000330; Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.12) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) CHD6 CHD5 KIAA1335 RIGB Homo sapiens (Human) TR18852_c3_g1_i1 B0R0I6 CHD8_DANRE 9.00E-18 GO:0005524; GO:0003677; GO:0071339; GO:0016055; GO:0003682; GO:0016568; GO:0004386; GO:0006355; GO:0006351 "ATP binding; DNA binding; MLL1 complex; Wnt receptor signaling pathway; chromatin binding; chromatin modification; helicase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006576; IPR023780; IPR000953; IPR016197; IPR014001; IPR001650; IPR027417; IPR001005; IPR000330; Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) chd8 si:ch211-10e2.6 wu:fi45h08 Danio rerio (Zebrafish) (Brachydanio rerio) TR18857_c2_g1_i1 Q68RJ7 ACH92_ONCMY 2.00E-13 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-9-II (Nicotinic acetylcholine receptor subunit alpha-9-II) (NACHR alpha-9-II) Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR18860_c0_g1_i1 O02350 CBPA1_ANOGA 6.00E-11 GO:0007586; GO:0005615; GO:0004181; GO:0006508; GO:0008270 digestion; extracellular space; metallocarboxypeptidase activity; proteolysis; zinc ion binding IPR000834; IPR003146; IPR009020; Zinc carboxypeptidase A 1 (EC 3.4.17.-) (AgCP) AGAP009593 Anopheles gambiae (African malaria mosquito) TR18865_c0_g1_i1 Q7Z3Z2 RD3_HUMAN 1.00E-10 GO:0050896; GO:0060041; GO:0007601 response to stimulus; retina development in camera-type eye; visual perception IPR028092; Protein RD3 (Retinal degeneration protein 3) RD3 C1orf36 Homo sapiens (Human) TR18870_c0_g1_i1 Q6QHF9 PAOX_HUMAN 5.00E-12 GO:0052899; GO:0052904; GO:0052903; GO:0005782; GO:0006598; GO:0046592; GO:1901307; GO:0009446; GO:0009447; GO:0044281; GO:0046203; GO:0052902; GO:0046208; GO:0052901; GO:0006805 "N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; peroxisomal matrix; polyamine catabolic process; polyamine oxidase activity; positive regulation of spermidine biosynthetic process; putrescine biosynthetic process; putrescine catabolic process; small molecule metabolic process; spermidine catabolic process; spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity; spermine catabolic process; spermine:oxygen oxidoreductase (spermidine-forming) activity; xenobiotic metabolic process" IPR002937; Amine and polyamine metabolism; spermine metabolism. Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC 1.5.3.13) (Polyamine oxidase) PAOX PAO UNQ1923/PRO4398 Homo sapiens (Human) TR18870_c0_g2_i1 Q9NWM0 SMOX_HUMAN 1.00E-13 GO:0052895; GO:0005737; GO:0005829; GO:0052894; GO:0005634; GO:0006596; GO:0006598; GO:0046592; GO:0044281; GO:0046208; GO:0052901; GO:0006805 N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity; cytoplasm; cytosol; norspermine:oxygen oxidoreductase activity; nucleus; polyamine biosynthetic process; polyamine catabolic process; polyamine oxidase activity; small molecule metabolic process; spermine catabolic process; spermine:oxygen oxidoreductase (spermidine-forming) activity; xenobiotic metabolic process IPR002937; Amine and polyamine degradation; spermine degradation. Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1) SMOX C20orf16 SMO UNQ3039/PRO9854 Homo sapiens (Human) TR18876_c0_g1_i1 Q3UY51 LRC55_MOUSE 8.00E-14 GO:0016021; GO:0006811; GO:0005886 integral to membrane; ion transport; plasma membrane IPR000483; IPR001611; IPR000372; Leucine-rich repeat-containing protein 55 (BK channel auxiliary gamma subunit LRRC55) Lrrc55 Gm351 Mus musculus (Mouse) TR18879_c0_g1_i1 Q7T163 KDIS_DANRE 7.00E-14 GO:0016021; GO:0005770; GO:0007399 integral to membrane; late endosome; nervous system development IPR002110; IPR020683; IPR011646; Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) kidins220 arms kidins220b si:dkeyp-7f8.3 si:dz119j18.2 zgc:63531 Danio rerio (Zebrafish) (Brachydanio rerio) TR18882_c0_g1_i1 Q9BYX4 IFIH1_HUMAN 1.00E-21 GO:0005524; GO:0003677; GO:0039528; GO:0005829; GO:0009597; GO:0003725; GO:0004386; GO:0045087; GO:0019048; GO:0032480; GO:0005634; GO:0032727; GO:0032728; GO:0016925; GO:0042981; GO:0034344; GO:0043021; GO:0003727; GO:0008270 Q7Z434; P11207; P30927; Q9EMA9; P04487 ATP binding; DNA binding; cytoplasmic pattern recognition receptor signaling pathway in response to virus; cytosol; detection of virus; double-stranded RNA binding; helicase activity; innate immune response; modulation by virus of host morphology or physiology; negative regulation of type I interferon production; nucleus; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; protein sumoylation; regulation of apoptotic process; regulation of type III interferon production; ribonucleoprotein complex binding; single-stranded RNA binding; zinc ion binding IPR001315; IPR011029; IPR006935; IPR014001; IPR001650; IPR027417; IPR021673; Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116) IFIH1 MDA5 RH116 Homo sapiens (Human) TR18889_c1_g1_i1 Q7TNC8 GLRA2_MOUSE 2.00E-23 GO:0030054; GO:0034707; GO:0016934; GO:0016594; GO:0005887; GO:0007218; GO:0045211; GO:0022824 cell junction; chloride channel complex; extracellular-glycine-gated chloride channel activity; glycine binding; integral to plasma membrane; neuropeptide signaling pathway; postsynaptic membrane; transmitter-gated ion channel activity IPR006028; IPR008127; IPR008129; IPR006202; IPR006201; IPR006029; IPR018000; Glycine receptor subunit alpha-2 Glra2 Mus musculus (Mouse) TR18891_c1_g1_i1 Q9DGD1 MGT4C_CHICK 4.00E-15 GO:0000139; GO:0008454; GO:0016021; GO:0046872; GO:0006486 "Golgi membrane; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; integral to membrane; metal ion binding; protein glycosylation" IPR006759; Protein modification; protein glycosylation. "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.-) (EC 2.4.1.145) (N-acetylglucosaminyltransferase VI) (GnT-VI) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)" MGAT4C Gallus gallus (Chicken) TR18891_c2_g1_i1 A4IID1 MGT4A_XENTR 5.00E-10 GO:0000139; GO:0008454; GO:0016021; GO:0046872; GO:0006486 "Golgi membrane; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; integral to membrane; metal ion binding; protein glycosylation" IPR006759; Protein modification; protein glycosylation. "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa) (GlcNAc-T IVa) (GnT-IVa) (N-acetylglucosaminyltransferase IVa) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa)" mgat4a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR18894_c0_g1_i1 Q9BY76 ANGL4_HUMAN 5.00E-18 GO:0001525; GO:0030154; GO:0044255; GO:0004857; GO:0005615; GO:0043066; GO:0051005; GO:0045766; GO:0051260; GO:0005578; GO:0001666; GO:0044281; GO:0070328 P05556; P18084 angiogenesis; cell differentiation; cellular lipid metabolic process; enzyme inhibitor activity; extracellular space; negative regulation of apoptotic process; negative regulation of lipoprotein lipase activity; positive regulation of angiogenesis; protein homooligomerization; proteinaceous extracellular matrix; response to hypoxia; small molecule metabolic process; triglyceride homeostasis IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-related protein 4 (Angiopoietin-like protein 4) (Hepatic fibrinogen/angiopoietin-related protein) (HFARP) ANGPTL4 ARP4 HFARP PGAR PP1158 PSEC0166 UNQ171/PRO197 Homo sapiens (Human) TR18894_c1_g1_i1 P19477 FIBA_PARPA 1.00E-23 IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein A (FREP-A) Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) TR18894_c1_g2_i1 Q80YX1 TENA_MOUSE 1.00E-26 GO:0005604; GO:0007155; GO:0005615; GO:0005614; GO:0060739; GO:0007528; GO:0014012; GO:0008284; GO:0010628; GO:0060740; GO:0045545 basement membrane; cell adhesion; extracellular space; interstitial matrix; mesenchymal-epithelial cell signaling involved in prostate gland development; neuromuscular junction development; peripheral nervous system axon regeneration; positive regulation of cell proliferation; positive regulation of gene expression; prostate gland epithelium morphogenesis; syndecan binding IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin (TN) (Hexabrachion) (Tenascin-C) (TN-C) Tnc Hxb Mus musculus (Mouse) TR18898_c0_g1_i1 Q5TU55 HPS5_ANOGA 1.00E-11 GO:0006726; GO:0031409; GO:0006622; GO:0050896; GO:0007601 eye pigment biosynthetic process; pigment binding; protein targeting to lysosome; response to stimulus; visual perception IPR015943; IPR017986; Hermansky-Pudlak syndrome 5 protein homolog (Protein pink) p Anopheles gambiae (African malaria mosquito) TR18898_c0_g2_i1 O15040 TCPR2_HUMAN 7.00E-40 GO:0006914; GO:0008219 O95166; Q9H0R8; P60520; Q9BXW4 autophagy; cell death IPR006624; IPR009091; IPR015943; IPR001680; IPR017986; Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297) TECPR2 KIAA0297 KIAA0329 Homo sapiens (Human) TR18899_c0_g1_i1 Q8NCC3 PAG15_HUMAN 7.00E-17 GO:0008374; GO:0047499; GO:0006672; GO:0005576; GO:0009062; GO:0004622; GO:0005764; GO:0005739; GO:0046470; GO:0005543 O-acyltransferase activity; calcium-independent phospholipase A2 activity; ceramide metabolic process; extracellular region; fatty acid catabolic process; lysophospholipase activity; lysosome; mitochondrion; phosphatidylcholine metabolic process; phospholipid binding IPR003386; Group XV phospholipase A2 (EC 2.3.1.-) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) PLA2G15 LYPLA3 UNQ341/PRO540 Homo sapiens (Human) TR18900_c0_g1_i1 Q9C005 DPY30_HUMAN 4.00E-28 GO:0005794; GO:0048188; GO:0016197; GO:0051568; GO:0006355; GO:0005802; GO:0006351 Itself; Q9UBL3 "Golgi apparatus; Set1C/COMPASS complex; endosomal transport; histone H3-K4 methylation; regulation of transcription, DNA-dependent; trans-Golgi network; transcription, DNA-dependent" IPR007858; Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L) DPY30 Homo sapiens (Human) TR18901_c0_g1_i1 Q8BMD6 CN101_MOUSE 8.00E-34 GO:0016021 integral to membrane IPR021280; Transmembrane protein 260 Tmem260 Mus musculus (Mouse) TR18904_c2_g1_i1 P17945 HGF_RAT 3.00E-11 GO:0000187; GO:0060326; GO:0000902; GO:0008283; GO:0006928; GO:0035729; GO:0042056; GO:0005615; GO:0008083; GO:0005171; GO:0048012; GO:0030212; GO:0001889; GO:0051450; GO:0043066; GO:0043154; GO:1901299; GO:0090201; GO:0031100; GO:2000573; GO:0030335; GO:0008284; GO:0050731; GO:0014068; GO:0046982; GO:0006508; GO:0060665; GO:0004252 activation of MAPK activity; cell chemotaxis; cell morphogenesis; cell proliferation; cellular component movement; cellular response to hepatocyte growth factor stimulus; chemoattractant activity; extracellular space; growth factor activity; hepatocyte growth factor receptor binding; hepatocyte growth factor receptor signaling pathway; hyaluronan metabolic process; liver development; myoblast proliferation; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of hydrogen peroxide-mediated programmed cell death; negative regulation of release of cytochrome c from mitochondria; organ regeneration; positive regulation of DNA biosynthetic process; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase cascade; protein heterodimerization activity; proteolysis; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; serine-type endopeptidase activity IPR027284; IPR024174; IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR001254; IPR001314; IPR009003; Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain] Hgf Rattus norvegicus (Rat) TR18904_c2_g2_i1 Q2TV78 MSTP9_HUMAN 4.00E-10 GO:0005576; GO:0006508; GO:0004252 extracellular region; proteolysis; serine-type endopeptidase activity IPR024174; IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR001254; IPR001314; IPR009003; Putative macrophage stimulating 1-like protein (Brain rescue factor 1) (BRF-1) (Hepatocyte growth factor-like protein homolog) MST1L D1F15S1A MST1P9 MSTP9 Homo sapiens (Human) TR18904_c3_g1_i1 P42674 BP10_PARLI 7.00E-44 GO:0005938; GO:0005615; GO:0004222; GO:0048471; GO:0006508; GO:0008270 cell cortex; extracellular space; metalloendopeptidase activity; perinuclear region of cytoplasm; proteolysis; zinc ion binding IPR000859; IPR000742; IPR013032; IPR024079; IPR001506; IPR006026; IPR017369; Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) TR18909_c0_g1_i1 Q9FT51 AB27G_ARATH 2.00E-66 GO:0005524; GO:0006200; GO:0016887; GO:0016021; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; integral to membrane; transport IPR003593; IPR013525; IPR003439; IPR017871; IPR027417; ABC transporter G family member 27 (ABC transporter ABCG.27) (AtABCG27) (Probable white-brown complex homolog protein 28) (AtWBC28) ABCG27 WBC28 At3g52310 T25B15.80 Arabidopsis thaliana (Mouse-ear cress) TR18915_c0_g1_i1 P38150 YB9Z_YEAST 5.00E-18 GO:0016021 integral to membrane IPR001365; IPR006329; Inactive deaminase YBR284W YBR284W YBR2021 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR18915_c0_g2_i1 Q9DBT5 AMPD2_MOUSE 1.00E-64 GO:0003876; GO:0032264; GO:0046872 AMP deaminase activity; IMP salvage; metal ion binding IPR006650; IPR001365; IPR006329; Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1. AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L) Ampd2 Mus musculus (Mouse) TR18918_c1_g1_i1 Q8HYI9 PFD5_BOVIN 4.00E-35 GO:0051086; GO:0005829; GO:0090090; GO:0045892; GO:0005634; GO:0016272 "chaperone mediated protein folding independent of cofactor; cytosol; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of transcription, DNA-dependent; nucleus; prefoldin complex" IPR011599; IPR027236; IPR009053; IPR004127; Prefoldin subunit 5 PFDN5 Bos taurus (Bovine) TR18921_c0_g1_i1 Q1EG27 MYO3B_MOUSE 2.00E-30 GO:0005524; GO:0005737; GO:0032433; GO:0000146; GO:0016459; GO:0018105; GO:0018107; GO:0001917; GO:0001750; GO:0051491; GO:0046777; GO:0004674; GO:0050896; GO:0032426; GO:0007601 ATP binding; cytoplasm; filopodium tip; microfilament motor activity; myosin complex; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; photoreceptor inner segment; photoreceptor outer segment; positive regulation of filopodium assembly; protein autophosphorylation; protein serine/threonine kinase activity; response to stimulus; stereocilium bundle tip; visual perception IPR000048; IPR011009; IPR001609; IPR027417; IPR000719; IPR017441; IPR002290; IPR008271; Myosin-IIIb (EC 2.7.11.1) Myo3b Mus musculus (Mouse) TR18921_c0_g2_i1 Q9Y6X6 MYO16_HUMAN 2.00E-26 GO:0005524; GO:0051015; GO:0021549; GO:0005829; GO:0003774; GO:0016459; GO:2000134; GO:0008285; GO:0048812; GO:0005730; GO:0005654; GO:0048471; GO:0014065; GO:0005886 ATP binding; actin filament binding; cerebellum development; cytosol; motor activity; myosin complex; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell proliferation; neuron projection morphogenesis; nucleolus; nucleoplasm; perinuclear region of cytoplasm; phosphatidylinositol 3-kinase cascade; plasma membrane IPR002110; IPR020683; IPR000048; IPR001609; IPR027417; Unconventional myosin-XVI (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16) MYO16 KIAA0865 MYO16B NYAP3 Homo sapiens (Human) TR18930_c0_g1_i1 P52738 ZN140_HUMAN 4.00E-10 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 140 ZNF140 Homo sapiens (Human) TR18930_c0_g1_i2 O43474 KLF4_HUMAN 3.00E-11 GO:0001077; GO:0001085; GO:0001190; GO:0071363; GO:0000987; GO:0003690; GO:0009913; GO:0048730; GO:0045444; GO:0007500; GO:0070373; GO:0032088; GO:0090051; GO:0008285; GO:2000342; GO:0043154; GO:0034115; GO:0050728; GO:0045415; GO:0014740; GO:0014067; GO:0051898; GO:0060761; GO:0048662; GO:0000122; GO:0000790; GO:0035014; GO:0046985; GO:0031077; GO:0035166; GO:0032526; GO:0001010; GO:0019827; GO:0005667; GO:0008270 Q13363 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II transcription factor binding; RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; cellular response to growth factor stimulus; core promoter proximal region sequence-specific DNA binding; double-stranded DNA binding; epidermal cell differentiation; epidermis morphogenesis; fat cell differentiation; mesodermal cell fate determination; negative regulation of ERK1 and ERK2 cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell proliferation; negative regulation of chemokine (C-X-C motif) ligand 2 production; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of heterotypic cell-cell adhesion; negative regulation of inflammatory response; negative regulation of interleukin-8 biosynthetic process; negative regulation of muscle hyperplasia; negative regulation of phosphatidylinositol 3-kinase cascade; negative regulation of protein kinase B signaling cascade; negative regulation of response to cytokine stimulus; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; phosphatidylinositol 3-kinase regulator activity; positive regulation of hemoglobin biosynthetic process; post-embryonic camera-type eye development; post-embryonic hemopoiesis; response to retinoic acid; sequence-specific DNA binding transcription factor recruiting transcription factor activity; stem cell maintenance; transcription factor complex; zinc ion binding IPR007087; IPR015880; IPR013087; Krueppel-like factor 4 (Epithelial zinc finger protein EZF) (Gut-enriched krueppel-like factor) KLF4 EZF GKLF Homo sapiens (Human) TR18930_c0_g1_i3 Q5R4X5 ZNF22_PONAB 3.00E-08 GO:0003677; GO:0046872; GO:0005730; GO:0005886; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleolus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 22 ZNF22 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR18930_c0_g1_i4 P13682 ZNF35_HUMAN 1.00E-11 GO:0071300; GO:0046872; GO:0005634; GO:0048471; GO:0043565; GO:0003700; GO:0007283; GO:0006351 "cellular response to retinoic acid; metal ion binding; nucleus; perinuclear region of cytoplasm; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; spermatogenesis; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 35 (Zinc finger protein HF.10) ZNF35 Homo sapiens (Human) TR18939_c0_g1_i1 Q80SU7 GVIN1_MOUSE 1.00E-12 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR027417; Interferon-induced very large GTPase 1 (Very large-inducible GTPase-1) (VLIG-1) Gvin1 Mus musculus (Mouse) TR1894_c0_g1_i1 O67528 NDK_AQUAE 2.00E-22 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0005737; GO:0046872; GO:0004550 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; cytoplasm; metal ion binding; nucleoside diphosphate kinase activity IPR001564; IPR023005; Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) (Nucleoside-2-P kinase) ndk aq_1590 Aquifex aeolicus (strain VF5) TR1894_c1_g1_i1 Q9Y5B8 NDK7_HUMAN 5.00E-24 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0007420; GO:0005813; GO:0060830; GO:0007368; GO:0003351; GO:0042073; GO:0060972; GO:0046872; GO:0004550 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; brain development; centrosome; ciliary receptor clustering involved in smoothened signaling pathway; determination of left/right symmetry; epithelial cilium movement; intraflagellar transport; left/right pattern formation; metal ion binding; nucleoside diphosphate kinase activity IPR011410; IPR001564; IPR006602; Nucleoside diphosphate kinase 7 (NDK 7) (NDP kinase 7) (EC 2.7.4.6) (nm23-H7) NME7 Homo sapiens (Human) TR18942_c2_g1_i1 Q13263 TIF1B_HUMAN 8.00E-07 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR18947_c0_g1_i1 A2A3L6 TTC24_HUMAN 1.00E-10 IPR013026; IPR011990; IPR001440; IPR024812; IPR019734; Tetratricopeptide repeat protein 24 (TPR repeat protein 24) TTC24 Homo sapiens (Human) TR18949_c0_g1_i1 Q9D842 APLF_MOUSE 5.00E-09 GO:0008408; GO:0003906; GO:0005829; GO:0006302; GO:0004520; GO:0046872; GO:0000166; GO:0005634; GO:0000012 3'-5' exonuclease activity; DNA-(apurinic or apyrimidinic site) lyase activity; cytosol; double-strand break repair; endodeoxyribonuclease activity; metal ion binding; nucleotide binding; nucleus; single strand break repair IPR000253; IPR008984; IPR019406; Aprataxin and PNK-like factor (EC 4.2.99.18) (Apurinic-apyrimidinic endonuclease APLF) Aplf Mus musculus (Mouse) TR18949_c0_g1_i2 A0JNH9 APLF_BOVIN 1.00E-09 GO:0008408; GO:0003906; GO:0005829; GO:0006302; GO:0004520; GO:0046872; GO:0000166; GO:0005634; GO:0000012 3'-5' exonuclease activity; DNA-(apurinic or apyrimidinic site) lyase activity; cytosol; double-strand break repair; endodeoxyribonuclease activity; metal ion binding; nucleotide binding; nucleus; single strand break repair IPR008984; IPR019406; Aprataxin and PNK-like factor (EC 4.2.99.18) (Apurinic-apyrimidinic endonuclease APLF) APLF Bos taurus (Bovine) TR18950_c1_g1_i1 O05389 YRBE_BACSU 3.00E-26 GO:0016491 oxidoreductase activity IPR016040; IPR000683; IPR004104; Uncharacterized oxidoreductase YrbE (EC 1.-.-.-) yrbE BSU27770 Bacillus subtilis (strain 168) TR18952_c1_g1_i1 B0BLU1 RN168_XENTR 8.00E-24 GO:0070530; GO:0003682; GO:0006302; GO:0070535; GO:0035518; GO:0036351; GO:0036352; GO:0042393; GO:0045190; GO:0045900; GO:0005634; GO:0045739; GO:0010212; GO:0035861; GO:0000151; GO:0006511; GO:0004842; GO:0008270 K63-linked polyubiquitin binding; chromatin binding; double-strand break repair; histone H2A K63-linked ubiquitination; histone H2A monoubiquitination; histone H2A-K13 ubiquitination; histone H2A-K15 ubiquitination; histone binding; isotype switching; negative regulation of translational elongation; nucleus; positive regulation of DNA repair; response to ionizing radiation; site of double-strand break; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR018957; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF168 (EC 6.3.2.-) (RING finger protein 168) rnf168 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR18953_c0_g1_i1 P86854 PLCL_MYTGA 4.00E-13 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR18953_c0_g2_i1 Q91ZW9 C209C_MOUSE 8.00E-08 GO:0005537; GO:0046872 mannose binding; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; CD209 antigen-like protein C (DC-SIGN-related protein 2) (DC-SIGNR2) (CD antigen CD209) Cd209c Mus musculus (Mouse) TR18954_c1_g1_i3 Q9NQG7 HPS4_HUMAN 5.00E-18 GO:0007596; GO:0007599; GO:0005764; GO:0007040; GO:0030318; GO:0042470; GO:0016020; GO:0042827; GO:0048075; GO:0050821; GO:0006605 Q92902 blood coagulation; hemostasis; lysosome; lysosome organization; melanocyte differentiation; melanosome; membrane; platelet dense granule; positive regulation of eye pigmentation; protein stabilization; protein targeting IPR026091; Hermansky-Pudlak syndrome 4 protein (Light-ear protein homolog) HPS4 KIAA1667 Homo sapiens (Human) TR18955_c1_g1_i2 P86854 PLCL_MYTGA 7.00E-22 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR18956_c0_g1_i1 Q9NWQ9 CN119_HUMAN 7.00E-28 GO:0005739 mitochondrion IPR028019; Uncharacterized protein C14orf119 C14orf119 My028 Homo sapiens (Human) TR18975_c0_g2_i1 P08110 ENPL_CHICK 1.00E-30 GO:0005524; GO:0005783; GO:0005788; GO:0006457; GO:0006950 ATP binding; endoplasmic reticulum; endoplasmic reticulum lumen; protein folding; response to stress IPR015566; IPR003594; IPR019805; IPR001404; IPR020575; IPR020568; Endoplasmin (Heat shock 108 kDa protein) (HSP 108) (HSP108) (Heat shock protein 90 kDa beta member 1) (Transferrin-binding protein) HSP90B1 TRA1 Gallus gallus (Chicken) TR18976_c1_g2_i1 P58743 S26A5_HUMAN 4.00E-42 GO:0016323; GO:0016021; GO:0016328; GO:0008360; GO:0042391; GO:0008271; GO:0007605; GO:0008272 basolateral plasma membrane; integral to membrane; lateral plasma membrane; regulation of cell shape; regulation of membrane potential; secondary active sulfate transmembrane transporter activity; sensory perception of sound; sulfate transport IPR018045; IPR002645; IPR001902; IPR011547; Prestin (Solute carrier family 26 member 5) SLC26A5 PRES Homo sapiens (Human) TR18977_c2_g1_i1 P70232 CHL1_MOUSE 4.00E-12 GO:0008344; GO:0045177; GO:0007411; GO:0007155; GO:0050890; GO:0030425; GO:0035640; GO:0016021; GO:0043524; GO:0001764; GO:0005886; GO:0005578 Q9JMB8; P18052 adult locomotory behavior; apical part of cell; axon guidance; cell adhesion; cognition; dendrite; exploration behavior; integral to membrane; negative regulation of neuron apoptotic process; neuron migration; plasma membrane; proteinaceous extracellular matrix IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR026966; Neural cell adhesion molecule L1-like protein (Cell adhesion molecule with homology to L1CAM) (Chl1-like protein) (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] Chl1 Call Mus musculus (Mouse) TR18978_c0_g1_i1 P98164 LRP2_HUMAN 8.00E-13 GO:0005794; GO:0016324; GO:0031526; GO:0005509; GO:0008283; GO:0005905; GO:0030139; GO:0005783; GO:0005768; GO:0030900; GO:0016021; GO:0005765; GO:0007603; GO:0006486; GO:0006898; GO:0001523; GO:0042359 "Golgi apparatus; apical plasma membrane; brush border membrane; calcium ion binding; cell proliferation; coated pit; endocytic vesicle; endoplasmic reticulum; endosome; forebrain development; integral to membrane; lysosomal membrane; phototransduction, visible light; protein glycosylation; receptor-mediated endocytosis; retinoid metabolic process; vitamin D metabolic process" IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; IPR019825; Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) LRP2 Homo sapiens (Human) TR18979_c0_g1_i1 A6QPT6 ZN274_BOVIN 3.00E-20 GO:0005813; GO:0005737; GO:0046872; GO:0005166; GO:0005730; GO:0005634; GO:0043565; GO:0000981 centrosome; cytoplasm; metal ion binding; neurotrophin p75 receptor binding; nucleolus; nucleus; sequence-specific DNA binding; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Neurotrophin receptor-interacting factor homolog (Zinc finger protein 274) ZNF274 Bos taurus (Bovine) TR18981_c1_g1_i1 P40237 CD82_MOUSE 3.00E-07 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1 homolog) (CD antigen CD82) Cd82 Kai1 Mus musculus (Mouse) TR18985_c0_g1_i1 O75976 CBPD_HUMAN 0 GO:0016021; GO:0016020; GO:0004181; GO:0006508; GO:0004185; GO:0008270 integral to membrane; membrane; metallocarboxypeptidase activity; proteolysis; serine-type carboxypeptidase activity; zinc ion binding IPR008969; IPR014766; IPR015567; IPR000834; Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180) CPD Homo sapiens (Human) TR18985_c1_g2_i1 Q0II73 CBPO_BOVIN 4.00E-09 GO:0005576; GO:0004181; GO:0006508; GO:0008270 extracellular region; metallocarboxypeptidase activity; proteolysis; zinc ion binding IPR000834; Carboxypeptidase O (CPO) (EC 3.4.17.-) CPO Bos taurus (Bovine) TR18985_c1_g3_i1 Q2KIG3 CBPB2_BOVIN 2.00E-07 GO:0007596; GO:0005576; GO:0042730; GO:0004181; GO:0006508; GO:0008270 blood coagulation; extracellular region; fibrinolysis; metallocarboxypeptidase activity; proteolysis; zinc ion binding IPR000834; IPR003146; IPR009020; Carboxypeptidase B2 (EC 3.4.17.20) (Carboxypeptidase U) (CPU) (Plasma carboxypeptidase B) (pCPB) (Thrombin-activable fibrinolysis inhibitor) (TAFI) CPB2 Bos taurus (Bovine) TR18989_c0_g1_i1 Q6C9W0 UBC12_YARLI 5.00E-15 GO:0005524; GO:0016881; GO:0045116 ATP binding; acid-amino acid ligase activity; protein neddylation IPR000608; IPR023313; IPR016135; Protein modification; protein neddylation. NEDD8-conjugating enzyme UBC12 (EC 6.3.2.-) (RUB1-conjugating enzyme) (RUB1-protein ligase) (Ubiquitin carrier protein 12) UBC12 YALI0D07890g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR18996_c0_g1_i1 Q9WUL6 M3K14_MOUSE 2.00E-06 GO:0005524; GO:0007249; GO:0004709; GO:0000165; GO:0004704; GO:0000186; GO:0005737; GO:0006955 ATP binding; I-kappaB kinase/NF-kappaB cascade; MAP kinase kinase kinase activity; MAPK cascade; NF-kappaB-inducing kinase activity; activation of MAPKK activity; cytoplasm; immune response IPR011009; IPR017425; IPR000719; IPR017441; IPR008271; Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (Serine/threonine-protein kinase NIK) Map3k14 Nik Mus musculus (Mouse) TR18998_c0_g1_i1 P25067 CO8A2_HUMAN 2.00E-06 GO:0001525; GO:0005604; GO:0048593; GO:0016337; GO:0005581; GO:0030574; GO:0005788; GO:0050673; GO:0022617; GO:0005201; GO:0030674 "angiogenesis; basement membrane; camera-type eye morphogenesis; cell-cell adhesion; collagen; collagen catabolic process; endoplasmic reticulum lumen; epithelial cell proliferation; extracellular matrix disassembly; extracellular matrix structural constituent; protein binding, bridging" IPR001073; IPR008160; IPR008983; Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) TR18999_c2_g1_i1 O14746 TERT_HUMAN 3.00E-28 GO:0022616; GO:0016605; GO:0003723; GO:0006278; GO:0003964; GO:0005737; GO:0046872; GO:2001240; GO:0000783; GO:0005730; GO:0005654; GO:0042803; GO:0090399; GO:0005697; GO:0032203; GO:0007004; GO:0042162; GO:0070034; GO:0003721 P29590-5; Q9Y265; Q92900 DNA strand elongation; PML body; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; cytoplasm; metal ion binding; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; nuclear telomere cap complex; nucleolus; nucleoplasm; protein homodimerization activity; replicative senescence; telomerase holoenzyme complex; telomere formation via telomerase; telomere maintenance via telomerase; telomeric DNA binding; telomeric RNA binding; telomeric template RNA reverse transcriptase activity IPR000477; IPR021891; IPR003545; Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2) TERT EST2 TCS1 TRT Homo sapiens (Human) TR19001_c1_g1_i1 P20771 YNHA_RHOER 3.00E-17 GO:0016884 "carbon-nitrogen ligase activity, with glutamine as amido-N-donor" IPR000120; IPR023631; Uncharacterized protein in nthA 5'region (Fragment) Rhodococcus erythropolis (Arthrobacter picolinophilus) TR19001_c1_g1_i2 Q9CJ43 GATA_LACLA 1.00E-11 GO:0005524; GO:0050567; GO:0006412 ATP binding; glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity; translation IPR000120; IPR020556; IPR023631; IPR004412; Glutamyl-tRNA(Gln) amidotransferase subunit A (Glu-ADT subunit A) (EC 6.3.5.-) gatA LL0163 L0473 Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) TR19006_c0_g1_i1 P0CH38 FBSP1_RAT 1.00E-13 GO:0030054; GO:0007399; GO:0045211; GO:0042734; GO:0016567 cell junction; nervous system development; postsynaptic membrane; presynaptic membrane; protein ubiquitination IPR001870; IPR008985; IPR018355; IPR003877; Protein modification; protein ubiquitination. F-box/SPRY domain-containing protein 1 (F-box only protein 45) (Fragment) Fbxo45 Rattus norvegicus (Rat) TR19006_c0_g1_i3 Q5E9X6 SPSB1_BOVIN 1.00E-12 GO:0005737; GO:0035556; GO:0016567 cytoplasm; intracellular signal transduction; protein ubiquitination IPR001870; IPR008985; IPR001496; IPR018355; IPR003877; Protein modification; protein ubiquitination. SPRY domain-containing SOCS box protein 1 (SSB-1) SPSB1 SSB1 Bos taurus (Bovine) TR19007_c0_g1_i1 O15973 OPSD1_MIZYE 4.00E-13 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR000856; IPR027430; "Rhodopsin, GQ-coupled (GQ-rhodopsin)" SCOP1 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) TR19014_c0_g1_i1 P10675 FAS1_SCHAM 2.00E-13 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR000782; Fasciclin-1 (Fasciclin I) (FAS I) (FCN) FAS1 Schistocerca americana (American grasshopper) TR19016_c1_g1_i1 Q8C4U2 TM145_MOUSE 1.00E-48 GO:0007186; GO:0016021; GO:0019236 G-protein coupled receptor signaling pathway; integral to membrane; response to pheromone IPR019336; Transmembrane protein 145 Tmem145 Mus musculus (Mouse) TR19024_c0_g1_i1 Q66J99 RBM18_XENLA 4.00E-38 GO:0003723; GO:0000166 RNA binding; nucleotide binding IPR012677; IPR000504; Probable RNA-binding protein 18 (RNA-binding motif protein 18) rbm18 Xenopus laevis (African clawed frog) TR19026_c0_g1_i1 Q5UPE4 COLL1_MIMIV 6.00E-10 GO:0005581; GO:0019012 collagen; virion IPR008160; IPR021210; Collagen-like protein 1 MIMI_L71 Acanthamoeba polyphaga mimivirus (APMV) TR19027_c0_g1_i2 Q0D2G3 CJ057_BOVIN 1.00E-11 GO:0016021 integral to membrane IPR028110; Transmembrane protein 254 TMEM254 Bos taurus (Bovine) TR19029_c0_g1_i1 Q5SQM0 EMAL6_MOUSE 3.00E-28 GO:0005737; GO:0005874 cytoplasm; microtubule IPR005108; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like) Eml6 Eml5l Mus musculus (Mouse) TR1904_c1_g1_i1 Q8K3U7 PRDX2_CRIGR 2.00E-16 GO:0005737; GO:0004601; GO:0051920 cytoplasm; peroxidase activity; peroxiredoxin activity IPR000866; IPR024706; IPR019479; IPR012336; Peroxiredoxin-2 (EC 1.11.1.15) PRDX2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR19044_c0_g1_i1 P10076 ZFP26_MOUSE 4.00E-20 GO:0003677; GO:0046872; GO:0005634; GO:0006355 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 26 (Zfp-26) (Protein mKR3) Zfp26 Kiaa4196 Mkr3 Zfp-26 Mus musculus (Mouse) TR19044_c0_g1_i2 P17141 ZFP37_MOUSE 7.00E-19 GO:0003677; GO:0007281; GO:0007275; GO:0005634; GO:0006355; GO:0007283; GO:0006351; GO:0008270 "DNA binding; germ cell development; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; spermatogenesis; transcription, DNA-dependent; zinc ion binding" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 37 (Zfp-37) (Male germ cell-specific zinc finger protein) Zfp37 Zfp-37 Mus musculus (Mouse) TR19046_c1_g1_i1 Q46GW1 UCRI_PROMT 4.00E-08 GO:0051537; GO:0045158; GO:0016021; GO:0046872; GO:0015979; GO:0009496; GO:0042651; GO:0008121 "2 iron, 2 sulfur cluster binding; electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity; integral to membrane; metal ion binding; photosynthesis; plastoquinol--plastocyanin reductase activity; thylakoid membrane; ubiquinol-cytochrome-c reductase activity" IPR014909; IPR023960; IPR017941; IPR014349; IPR005805; IPR006311; Cytochrome b6-f complex iron-sulfur subunit (EC 1.10.9.1) (Plastohydroquinone:plastocyanin oxidoreductase iron-sulfur protein) (ISP) (RISP) (Rieske iron-sulfur protein) petC PMN2A_1794 Prochlorococcus marinus (strain NATL2A) TR19046_c1_g2_i1 Q69BK3 UCRI_PONPY 2.00E-72 GO:0051537; GO:0016021; GO:0046872; GO:0005743; GO:0070469; GO:0008121 "2 iron, 2 sulfur cluster binding; integral to membrane; metal ion binding; mitochondrial inner membrane; respiratory chain; ubiquinol-cytochrome-c reductase activity" IPR011070; IPR017941; IPR014349; IPR005805; IPR015248; IPR006317; IPR004192; "Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 1.10.2.2) (Complex III subunit 5) (Cytochrome b-c1 complex subunit 5) (Rieske iron-sulfur protein) (RISP) (Ubiquinol-cytochrome c reductase iron-sulfur subunit) [Cleaved into: Cytochrome b-c1 complex subunit 11 (Complex III subunit IX) (Ubiquinol-cytochrome c reductase 8 kDa protein)]" UQCRFS1 Pongo pygmaeus (Bornean orangutan) TR19051_c0_g1_i1 Q6P828 LITAF_XENTR 3.00E-17 GO:0005737; GO:0006355; GO:0006351 "cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) litaf TEgg087j16.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR19053_c0_g1_i1 Q8R151 ZNFX1_MOUSE 2.00E-38 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR19053_c2_g1_i2 Q8R151 ZNFX1_MOUSE 1.00E-28 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR19054_c0_g1_i1 Q99JY3 GIMA4_MOUSE 2.00E-19 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Mus musculus (Mouse) TR19057_c0_g1_i1 Q9R0B9 PLOD2_MOUSE 4.00E-30 GO:0031418; GO:0005506; GO:0008475; GO:0030867 L-ascorbic acid binding; iron ion binding; procollagen-lysine 5-dioxygenase activity; rough endoplasmic reticulum membrane IPR005123; IPR006620; IPR001006; "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (EC 1.14.11.4) (Lysyl hydroxylase 2) (LH2)" Plod2 Mus musculus (Mouse) TR19061_c1_g2_i1 Q13263 TIF1B_HUMAN 2.00E-07 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR19062_c0_g1_i1 P55641 Y4RH_RHISN 2.00E-11 GO:0005524; GO:0016874; GO:0046872 ATP binding; ligase activity; metal ion binding IPR011761; IPR013816; IPR005479; IPR016185; Uncharacterized protein y4rH NGR_a01790 y4rH Rhizobium sp. (strain NGR234) TR19062_c0_g2_i1 A5YM72 CRNS1_HUMAN 7.00E-66 GO:0005524; GO:0016887; GO:0035499; GO:0047730; GO:0046872 ATP binding; ATPase activity; carnosine biosynthetic process; carnosine synthase activity; metal ion binding IPR011761; IPR013816; Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) TR19067_c0_g1_i2 Q09506 YQI7_CAEEL 2.00E-27 GO:0030111 G5EF99 regulation of Wnt receptor signaling pathway IPR001478; IPR017268; Uncharacterized protein C45G9.7 C45G9.7 Caenorhabditis elegans TR19072_c0_g1_i1 E1BLZ4 ZFY26_BOVIN 6.00E-27 GO:0006281; GO:0005813; GO:0000910; GO:0005737; GO:0046872; GO:0030496; GO:0032266 DNA repair; centrosome; cytokinesis; cytoplasm; metal ion binding; midbody; phosphatidylinositol-3-phosphate binding IPR000306; IPR017455; IPR011011; IPR013083; Zinc finger FYVE domain-containing protein 26 ZFYVE26 Bos taurus (Bovine) TR19076_c0_g1_i1 P41234 ABCA2_MOUSE 2.00E-13 GO:0005524; GO:0016887; GO:0042632; GO:0016023; GO:0005768; GO:0010008; GO:0016021; GO:0005765; GO:0005815; GO:0032383; GO:0006357; GO:0048545; GO:0006810 ATP binding; ATPase activity; cholesterol homeostasis; cytoplasmic membrane-bounded vesicle; endosome; endosome membrane; integral to membrane; lysosomal membrane; microtubule organizing center; regulation of intracellular cholesterol transport; regulation of transcription from RNA polymerase II promoter; response to steroid hormone stimulus; transport IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 2 (ATP-binding cassette transporter 2) (ATP-binding cassette 2) Abca2 Abc2 Mus musculus (Mouse) TR19081_c0_g1_i1 O76217 PE1_ANOGA 2.00E-06 GO:0008061; GO:0006030; GO:0005576 chitin binding; chitin metabolic process; extracellular region IPR002557; Peritrophin-1 (AgAper-1) (Peritrophic matrix protein 1) (Peritrophin A) Aper1 AGAP006795 Anopheles gambiae (African malaria mosquito) TR19082_c1_g1_i1 Q8CDL9 CCD87_MOUSE 2.00E-29 GO:0000910; GO:0000226 cytokinesis; microtubule cytoskeleton organization IPR007145; Coiled-coil domain-containing protein 87 Ccdc87 Mus musculus (Mouse) TR19085_c0_g1_i2 Q86Y13 DZIP3_HUMAN 1.00E-06 GO:0003723; GO:0005737; GO:0019902; GO:0031593; GO:0000209; GO:0004842; GO:0008270 Q9H0E2 RNA binding; cytoplasm; phosphatase binding; polyubiquitin binding; protein polyubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) TR19086_c1_g2_i1 Q9Z139 ROR1_MOUSE 7.00E-07 GO:0005524; GO:0005887; GO:0004714; GO:0007169 ATP binding; integral to plasma membrane; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR020067; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000001; IPR013806; IPR018056; IPR000719; IPR001245; IPR008266; IPR020635; IPR016247; "Tyrosine-protein kinase transmembrane receptor ROR1 (mROR1) (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1)" Ror1 Ntrkr1 Mus musculus (Mouse) TR19087_c1_g1_i1 Q8K0U4 HS12A_MOUSE 1.00E-27 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR19091_c0_g1_i1 P24534 EF1B_HUMAN 5.00E-83 GO:0005829; GO:0005853; GO:0003746 P26641 cytosol; eukaryotic translation elongation factor 1 complex; translation elongation factor activity IPR018940; IPR010987; IPR014717; IPR001326; IPR014038; Elongation factor 1-beta (EF-1-beta) EEF1B2 EEF1B EF1B Homo sapiens (Human) TR19094_c0_g1_i1 P48375 FKB12_DROME 6.00E-39 GO:0005528; GO:0005737; GO:0016020; GO:0003755; GO:0006457; GO:0006974 FK506 binding; cytoplasm; membrane; peptidyl-prolyl cis-trans isomerase activity; protein folding; response to DNA damage stimulus IPR023566; IPR001179; 12 kDa FK506-binding protein (FKBP) (EC 5.2.1.8) (Macrolide-binding protein) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) FK506-bp2 FKBP12 CG11001 Drosophila melanogaster (Fruit fly) TR1910_c0_g1_i1 Q9Y818 UBC15_SCHPO 2.00E-12 GO:0005524; GO:0030466; GO:0005634; GO:0004842 ATP binding; chromatin silencing at silent mating-type cassette; nucleus; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 15 (EC 6.3.2.19) (Ubiquitin carrier protein 15) (Ubiquitin-protein ligase 15) ubc15 SPBC1105.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR19101_c0_g3_i1 Q9QZH2 BARD1_RAT 5.00E-13 GO:0031436; GO:0006281; GO:0005737; GO:0016874; GO:0043066; GO:0046826; GO:0043065; GO:0085020; GO:0042803; GO:0042325; GO:0007283; GO:0008270 BRCA1-BARD1 complex; DNA repair; cytoplasm; ligase activity; negative regulation of apoptotic process; negative regulation of protein export from nucleus; positive regulation of apoptotic process; protein K6-linked ubiquitination; protein homodimerization activity; regulation of phosphorylation; spermatogenesis; zinc ion binding IPR002110; IPR020683; IPR001357; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. BRCA1-associated RING domain protein 1 (BARD-1) (EC 6.3.2.-) Bard1 Rattus norvegicus (Rat) TR19101_c0_g3_i2 Q9H9B1 EHMT1_HUMAN 2.00E-19 GO:0006306; GO:0005694; GO:0009790; GO:0046976; GO:0046974; GO:0000122; GO:0045892; GO:0005634; GO:0018027; GO:0018026; GO:0008270 Q99549; Q04206; Q04207 "DNA methylation; chromosome; embryo development; histone methyltransferase activity (H3-K27 specific); histone methyltransferase activity (H3-K9 specific); negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; peptidyl-lysine dimethylation; peptidyl-lysine monomethylation; zinc ion binding" IPR002110; IPR020683; IPR007728; IPR003606; IPR001214; Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) EHMT1 EUHMTASE1 GLP KIAA1876 KMT1D Homo sapiens (Human) TR19102_c1_g1_i1 P28572 SC6A9_RAT 1.00E-71 GO:0015187; GO:0005887; GO:0005328; GO:0005283 P31016 glycine transmembrane transporter activity; integral to plasma membrane; neurotransmitter:sodium symporter activity; sodium:amino acid symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) Slc6a9 Rattus norvegicus (Rat) TR19104_c1_g1_i1 P13214 ANXA4_BOVIN 6.00E-34 GO:0005509; GO:0005544 calcium ion binding; calcium-dependent phospholipid binding IPR001464; IPR018502; IPR018252; IPR002391; Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Carbohydrate-binding protein p33/p41) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II) ANXA4 ANX4 Bos taurus (Bovine) TR19104_c1_g2_i1 Q3ZC08 ANXA9_BOVIN 8.00E-11 GO:0005509; GO:0005544 calcium ion binding; calcium-dependent phospholipid binding IPR001464; IPR018502; IPR018252; IPR009116; Annexin A9 (Annexin-9) ANXA9 Bos taurus (Bovine) TR19109_c0_g1_i1 P37167 ACTP_ACACA 4.00E-09 GO:0015629; GO:0030042; GO:0005737 actin cytoskeleton; actin filament depolymerization; cytoplasm IPR002108; IPR017904; Actophorin Acanthamoeba castellanii (Amoeba) TR19110_c4_g1_i1 Q9BVV6 K0586_HUMAN 2.00E-06 GO:0005813; GO:0060271; GO:0005737; GO:0007224 centrosome; cilium morphogenesis; cytoplasm; smoothened signaling pathway Protein TALPID3 KIAA0586 TALPID3 Homo sapiens (Human) TR19112_c1_g1_i2 P10611 CP4A4_RABIT 3.00E-29 GO:0070330; GO:0005789; GO:0020037; GO:0016021; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 4A4 (EC 1.14.14.1) (CYPIVA4) (Cytochrome P450-P-2) (Prostaglandin omega-hydroxylase) CYP4A4 Oryctolagus cuniculus (Rabbit) TR19112_c1_g2_i1 O46051 C4D14_DROME 8.00E-14 GO:0005789; GO:0020037; GO:0005506; GO:0004497; GO:0016705 "endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Probable cytochrome P450 4d14 (EC 1.14.-.-) (CYPIVD14) Cyp4d14 CG3540 Drosophila melanogaster (Fruit fly) TR19115_c0_g1_i1 Q6DDB9 PNO1_XENTR 1.00E-84 GO:0003723; GO:0005730 RNA binding; nucleolus IPR004087; IPR004088; RNA-binding protein PNO1 pno1 TTpA007f20.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR19121_c0_g1_i1 P08051 MLR_SPISA 3.00E-62 GO:0005509; GO:0016459 calcium ion binding; myosin complex IPR011992; IPR018247; IPR002048; "Myosin regulatory light chain, smooth muscle" Spisula sachalinensis (Sakhalin surf-clam) TR19124_c0_g1_i1 P22807 SLOU_DROME 8.00E-42 GO:0007501; GO:0007521; GO:0007517; GO:0000122; GO:0005634; GO:0043565; GO:0003700 mesodermal cell fate specification; muscle cell fate determination; muscle organ development; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein slou (Homeobox protein NK-1) (Protein slouch) (S59/2) slou NK1 S59 CG6534 Drosophila melanogaster (Fruit fly) TR19126_c1_g1_i1 O15990 KARG_LIOJA 3.00E-68 GO:0005524; GO:0004054 ATP binding; arginine kinase activity IPR022415; IPR022414; IPR022413; IPR014746; Arginine kinase (AK) (EC 2.7.3.3) Liolophura japonica (Chiton) (Acanthopleura japonica) TR19131_c0_g2_i2 Q17NH9 MED11_AEDAE 4.00E-33 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR019404; Mediator of RNA polymerase II transcription subunit 11 (Mediator complex subunit 11) MED11 AAEL000720 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR19133_c1_g1_i1 Q08821 HXA1_XENLA 1.00E-28 GO:0007275; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein Hox-A1 (Hox.lab2) (Fragment) hoxa1 Xenopus laevis (African clawed frog) TR19137_c0_g2_i1 Q7RTW8 OTOAN_HUMAN 9.00E-06 GO:0031225; GO:0016324; GO:0005578; GO:0007605 anchored to membrane; apical plasma membrane; proteinaceous extracellular matrix; sensory perception of sound IPR026663; IPR026664; Otoancorin OTOA Homo sapiens (Human) TR19140_c0_g1_i1 Q9BMX5 RS6_APLCA 2.00E-123 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR014401; IPR001377; IPR018282; 40S ribosomal protein S6 RPS6 Aplysia californica (California sea hare) TR19151_c0_g1_i1 P42577 FRIS_LYMST 5.00E-72 GO:0006879; GO:0005737; GO:0008199; GO:0004322; GO:0006826 cellular iron ion homeostasis; cytoplasm; ferric iron binding; ferroxidase activity; iron ion transport IPR001519; IPR009040; IPR009078; IPR012347; IPR014034; IPR008331; Soma ferritin (EC 1.16.3.1) Lymnaea stagnalis (Great pond snail) TR19153_c0_g1_i1 P10394 POL4_DROME 5.00E-24 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR19154_c1_g1_i1 O14544 SOCS6_HUMAN 2.00E-35 GO:0007259; GO:0005737; GO:0006952; GO:0001772; GO:0050868; GO:0009968; GO:0010498; GO:0016567; GO:0040008 JAK-STAT cascade; cytoplasm; defense response; immunological synapse; negative regulation of T cell activation; negative regulation of signal transduction; proteasomal protein catabolic process; protein ubiquitination; regulation of growth IPR000980; IPR001496; Protein modification; protein ubiquitination. Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4) SOCS6 CIS4 SOCS4 Homo sapiens (Human) TR19156_c0_g1_i1 Q1EA11 CCR4_COCIM 5.00E-09 GO:0003723; GO:0005737; GO:0046872; GO:0090305; GO:0005634; GO:0004535; GO:0006355; GO:0006351 "RNA binding; cytoplasm; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleus; poly(A)-specific ribonuclease activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR005135; IPR001611; IPR025875; Glucose-repressible alcohol dehydrogenase transcriptional effector (EC 3.1.13.4) (Carbon catabolite repressor protein 4) (Cytoplasmic deadenylase) CCR4 CIMG_00602 Coccidioides immitis (strain RS) (Valley fever fungus) TR19156_c2_g2_i1 Q5ZLN0 LRC40_CHICK 2.00E-21 IPR001611; IPR025875; IPR003591; Leucine-rich repeat-containing protein 40 LRRC40 RCJMB04_5h5 Gallus gallus (Chicken) TR19157_c0_g1_i1 Q8IZE3 PACE1_HUMAN 2.00E-28 GO:0005524; GO:0005794; GO:0016477; GO:0030027; GO:0006468; GO:0016772 P15311 "ATP binding; Golgi apparatus; cell migration; lamellipodium; protein phosphorylation; transferase activity, transferring phosphorus-containing groups" IPR011989; IPR016024; IPR021133; IPR011009; IPR000719; Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin-binding protein PACE-1) (SCY1-like protein 3) SCYL3 PACE1 Homo sapiens (Human) TR19161_c3_g1_i1 P17336 CATA_DROME 6.00E-60 GO:0004096; GO:0008340; GO:0020037; GO:0042744; GO:0046872; GO:0005777; GO:0035206; GO:0042542 catalase activity; determination of adult lifespan; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxisome; regulation of hemocyte proliferation; response to hydrogen peroxide IPR018028; IPR020835; IPR024708; IPR024711; IPR011614; IPR002226; IPR010582; Catalase (EC 1.11.1.6) Cat CG6871 Drosophila melanogaster (Fruit fly) TR19161_c5_g1_i1 Q59602 CATA_NEIGO 4.00E-28 GO:0004096; GO:0020037; GO:0042744; GO:0046872 catalase activity; heme binding; hydrogen peroxide catabolic process; metal ion binding IPR018028; IPR020835; IPR024708; IPR024711; IPR011614; IPR002226; IPR010582; Catalase (EC 1.11.1.6) katA Neisseria gonorrhoeae TR19162_c0_g1_i1 Q65YR7 CYTA2_DICDI 9.00E-15 GO:0004869; GO:0005829; GO:0006508 cysteine-type endopeptidase inhibitor activity; cytosol; proteolysis IPR000010; IPR001713; Cystatin-A2 cpiB DDB_G0280439 Dictyostelium discoideum (Slime mold) TR19167_c0_g1_i1 Q9BYK8 PR285_HUMAN 1.00E-09 GO:0005524; GO:0003677; GO:0044255; GO:0004386; GO:0030374; GO:0046872; GO:0005654; GO:0045944; GO:0044281; GO:0006351 "ATP binding; DNA binding; cellular lipid metabolic process; helicase activity; ligand-dependent nuclear receptor transcription coactivator activity; metal ion binding; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; small molecule metabolic process; transcription, DNA-dependent" IPR003593; IPR026122; IPR012340; IPR027417; IPR022966; IPR015880; "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) TR19167_c1_g1_i1 Q9BYK8 PR285_HUMAN 3.00E-13 GO:0005524; GO:0003677; GO:0044255; GO:0004386; GO:0030374; GO:0046872; GO:0005654; GO:0045944; GO:0044281; GO:0006351 "ATP binding; DNA binding; cellular lipid metabolic process; helicase activity; ligand-dependent nuclear receptor transcription coactivator activity; metal ion binding; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; small molecule metabolic process; transcription, DNA-dependent" IPR003593; IPR026122; IPR012340; IPR027417; IPR022966; IPR015880; "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) TR19168_c0_g2_i1 Q9CXE6 XRCC3_MOUSE 3.00E-12 GO:0005524; GO:0003677; GO:0006310; GO:0006281; GO:0008094; GO:0005759; GO:0005634; GO:0048471 ATP binding; DNA binding; DNA recombination; DNA repair; DNA-dependent ATPase activity; mitochondrial matrix; nucleus; perinuclear region of cytoplasm IPR013632; IPR016467; IPR020588; IPR027417; DNA repair protein XRCC3 (X-ray repair cross-complementing protein 3) Xrcc3 Mus musculus (Mouse) TR19168_c0_g2_i2 Q14565 DMC1_HUMAN 4.00E-165 GO:0005524; GO:0003677; GO:0008094; GO:0000781; GO:0000794; GO:0007292; GO:0007141; GO:0001556; GO:0001541; GO:0007131; GO:0007286; GO:0007283; GO:0007129 P51587 "ATP binding; DNA binding; DNA-dependent ATPase activity; chromosome, telomeric region; condensed nuclear chromosome; female gamete generation; male meiosis I; oocyte maturation; ovarian follicle development; reciprocal meiotic recombination; spermatid development; spermatogenesis; synapsis" IPR003593; IPR011940; IPR013632; IPR016467; IPR020588; IPR010995; IPR027417; IPR020587; Meiotic recombination protein DMC1/LIM15 homolog DMC1 DMC1H LIM15 Homo sapiens (Human) TR19173_c0_g1_i1 Q03958 PFD6_MOUSE 4.00E-30 GO:0051131; GO:0005634; GO:0016272; GO:0006457 chaperone-mediated protein complex assembly; nucleus; prefoldin complex; protein folding IPR002777; IPR009053; Prefoldin subunit 6 (Protein Ke2) Pfdn6 H2-Ke2 Pfd6 Mus musculus (Mouse) TR19176_c1_g1_i1 O43435 TBX1_HUMAN 9.00E-104 GO:0003677; GO:0001525; GO:0009952; GO:0035909; GO:0001974; GO:0001708; GO:0008283; GO:0044344; GO:0071300; GO:0090103; GO:0060982; GO:0007368; GO:0048703; GO:0070166; GO:0030855; GO:0060325; GO:0007507; GO:0001945; GO:0097152; GO:0007498; GO:0042474; GO:0042693; GO:0060415; GO:0045596; GO:2001054; GO:0001755; GO:0005634; GO:0071600; GO:0042473; GO:0003148; GO:0060017; GO:0060037; GO:0043410; GO:0050679; GO:0002053; GO:0001934; GO:0072513; GO:2001037; GO:0045944; GO:0045893; GO:0046983; GO:0042803; GO:2000027; GO:0048384; GO:0048752; GO:0007605; GO:0043565; GO:0035176; GO:0060023; GO:0048538; GO:0030878; GO:0043587; GO:0006351; GO:0021644 "DNA binding; angiogenesis; anterior/posterior pattern specification; aorta morphogenesis; blood vessel remodeling; cell fate specification; cell proliferation; cellular response to fibroblast growth factor stimulus; cellular response to retinoic acid; cochlea morphogenesis; coronary artery morphogenesis; determination of left/right symmetry; embryonic viscerocranium morphogenesis; enamel mineralization; epithelial cell differentiation; face morphogenesis; heart development; lymph vessel development; mesenchymal cell apoptotic process; mesoderm development; middle ear morphogenesis; muscle cell fate commitment; muscle tissue morphogenesis; negative regulation of cell differentiation; negative regulation of mesenchymal cell apoptotic process; neural crest cell migration; nucleus; otic vesicle morphogenesis; outer ear morphogenesis; outflow tract septum morphogenesis; parathyroid gland development; pharyngeal system development; positive regulation of MAPK cascade; positive regulation of epithelial cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of protein phosphorylation; positive regulation of secondary heart field cardioblast proliferation; positive regulation of tongue muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein dimerization activity; protein homodimerization activity; regulation of organ morphogenesis; retinoic acid receptor signaling pathway; semicircular canal morphogenesis; sensory perception of sound; sequence-specific DNA binding; social behavior; soft palate development; thymus development; thyroid gland development; tongue morphogenesis; transcription, DNA-dependent; vagus nerve morphogenesis" IPR008967; IPR001699; IPR018186; T-box transcription factor TBX1 (T-box protein 1) (Testis-specific T-box protein) TBX1 Homo sapiens (Human) TR19180_c2_g1_i1 Q9EPR2 PG12A_MOUSE 6.00E-23 GO:0005794; GO:0005509; GO:0005783; GO:0005576; GO:0016042; GO:0004623; GO:0006644 Golgi apparatus; calcium ion binding; endoplasmic reticulum; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR013090; IPR016090; IPR010711; Group XIIA secretory phospholipase A2 (GXII sPLA2) (sPLA2-XII) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A) Pla2g12a Pla2g12 Mus musculus (Mouse) TR19181_c2_g1_i1 P97481 EPAS1_MOUSE 1.00E-07 GO:0003677; GO:0001077; GO:0001525; GO:0001974; GO:0048469; GO:0005737; GO:0001892; GO:0030218; GO:0035035; GO:0030324; GO:0007005; GO:0048625; GO:0042415; GO:0005634; GO:0002027; GO:0043619; GO:0001666; GO:0043565; GO:0004871; GO:0043129; GO:0005667; GO:0007601 DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; angiogenesis; blood vessel remodeling; cell maturation; cytoplasm; embryonic placenta development; erythrocyte differentiation; histone acetyltransferase binding; lung development; mitochondrion organization; myoblast fate commitment; norepinephrine metabolic process; nucleus; regulation of heart rate; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; response to hypoxia; sequence-specific DNA binding; signal transducer activity; surfactant homeostasis; transcription factor complex; visual perception IPR011598; IPR014887; IPR021537; IPR001067; IPR001610; IPR000014; IPR013767; Endothelial PAS domain-containing protein 1 (EPAS-1) (HIF-1-alpha-like factor) (HLF) (mHLF) (HIF-related factor) (HRF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) Epas1 Hif2a Mus musculus (Mouse) TR19182_c0_g1_i1 Q60755 CALCR_MOUSE 3.00E-26 GO:0001669; GO:0007189; GO:0004948; GO:0005929; GO:0007204; GO:0016021; GO:0030279; GO:0030316; GO:0005886; GO:0043488 acrosomal vesicle; adenylate cyclase-activating G-protein coupled receptor signaling pathway; calcitonin receptor activity; cilium; elevation of cytosolic calcium ion concentration; integral to membrane; negative regulation of ossification; osteoclast differentiation; plasma membrane; regulation of mRNA stability IPR003287; IPR017981; IPR001688; IPR001879; IPR000832; IPR017983; Calcitonin receptor (CT-R) Calcr Mus musculus (Mouse) TR19188_c0_g1_i1 Q8BT51 CHCH8_MOUSE 5.00E-10 GO:0005739 mitochondrion IPR010625; "Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (Coiled-coil-helix-coiled-coil-helix domain-containing protein 8)" COA4 Chchd8 Mus musculus (Mouse) TR19192_c0_g1_i1 Q02386 ZNF45_HUMAN 6.00E-37 GO:0003677; GO:0046872; GO:0007275; GO:0005654; GO:0003700; GO:0006367 DNA binding; metal ion binding; multicellular organismal development; nucleoplasm; sequence-specific DNA binding transcription factor activity; transcription initiation from RNA polymerase II promoter IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 45 (BRC1744) (Zinc finger protein 13) (Zinc finger protein KOX5) ZNF45 KOX5 ZNF13 Homo sapiens (Human) TR19192_c1_g1_i1 Q7JUR5 Y2744_DROME 3.00E-06 GO:0003677; GO:0050832; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; defense response to fungus; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Uncharacterized zinc finger protein CG12744 CG12744 Drosophila melanogaster (Fruit fly) TR19193_c0_g1_i1 O09131 GSTO1_MOUSE 1.00E-51 GO:0019852; GO:0071243; GO:0005737; GO:0005829; GO:0045174; GO:0004364; GO:0050610; GO:0060315; GO:0060316; GO:0010880; GO:0042178 L-ascorbic acid metabolic process; cellular response to arsenic-containing substance; cytoplasm; cytosol; glutathione dehydrogenase (ascorbate) activity; glutathione transferase activity; methylarsonate reductase activity; negative regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of ryanodine-sensitive calcium-release channel activity; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; xenobiotic catabolic process IPR010987; IPR004045; IPR004046; IPR005442; IPR012336; Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R) (p28) Gsto1 Gstx Gtsttl Mus musculus (Mouse) TR19195_c0_g1_i1 Q6NS60 FBX41_MOUSE 5.00E-09 IPR001810; IPR015880; F-box only protein 41 Fbxo41 D6Ertd538e Kiaa1940 Mus musculus (Mouse) TR19201_c1_g2_i1 Q5ZXN6 ANKX_LEGPH 1.00E-08 GO:0030430; GO:0009405; GO:0044605; GO:0032313 host cell cytoplasm; pathogenesis; phosphocholine transferase activity; regulation of Rab GTPase activity IPR002110; IPR020683; IPR003812; Phosphocholine transferase AnkX (PC transferase) (EC 2.7.1.-) (Ankyrin repeat-containing protein X) ankX legA8 lpg0695 Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) TR19205_c0_g1_i1 P82987 ATL3_HUMAN 1.00E-09 GO:0008237; GO:0005578; GO:0008270 metallopeptidase activity; proteinaceous extracellular matrix; zinc ion binding IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013273; IPR010909; IPR000884; ADAMTS-like protein 3 (ADAMTSL-3) (Punctin-2) ADAMTSL3 KIAA1233 Homo sapiens (Human) TR19207_c1_g1_i1 Q5R4Q3 SEC62_PONAB 4.00E-25 GO:0016235; GO:0005789; GO:0016021; GO:0045111; GO:0008565; GO:0005791 aggresome; endoplasmic reticulum membrane; integral to membrane; intermediate filament cytoskeleton; protein transporter activity; rough endoplasmic reticulum IPR004728; Translocation protein SEC62 (Translocation protein 1) (TP-1) SEC62 TLOC1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR19208_c0_g1_i1 Q9R1F8 TLR2_CRIGR 6.00E-14 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR19216_c0_g2_i1 Q8CGC6 RBM28_MOUSE 2.00E-80 GO:0005794; GO:0003723; GO:0008380; GO:0006397; GO:0005730; GO:0000166; GO:0005681 Golgi apparatus; RNA binding; RNA splicing; mRNA processing; nucleolus; nucleotide binding; spliceosomal complex IPR012677; IPR000504; RNA-binding protein 28 (RNA-binding motif protein 28) Rbm28 Mus musculus (Mouse) TR19218_c2_g2_i1 Q5DRC8 PCDB6_PANTR 5.00E-16 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR013164; Protocadherin beta-6 (PCDH-beta-6) PCDHB6 Pan troglodytes (Chimpanzee) TR19220_c0_g1_i1 Q9SKK0 EBF1_ARATH 5.00E-10 GO:0009873; GO:0010105; GO:0005634; GO:0016567; GO:0009723; GO:0006511 O49484; O24606; Q39255; Q9FHW7; P43291 ethylene mediated signaling pathway; negative regulation of ethylene mediated signaling pathway; nucleus; protein ubiquitination; response to ethylene stimulus; ubiquitin-dependent protein catabolic process IPR001810; IPR006553; Protein modification; protein ubiquitination. EIN3-binding F-box protein 1 (F-box/LRR-repeat protein 6) EBF1 FBL6 At2g25490 F13B15.15 Arabidopsis thaliana (Mouse-ear cress) TR19226_c4_g1_i1 O57321 EAA1_AMBTI 3.00E-32 GO:0016021; GO:0017153 integral to membrane; sodium:dicarboxylate symporter activity IPR001991; IPR018107; Excitatory amino acid transporter 1 (SEAAT1) SLC1A3 EAAT1 Ambystoma tigrinum (Eastern tiger salamander) TR19226_c6_g1_i1 Q25605 EAAT_ONCVO 1.00E-28 GO:0016021; GO:0017153 integral to membrane; sodium:dicarboxylate symporter activity IPR001991; IPR018107; Excitatory amino acid transporter (Sodium-dependent glutamate/ aspartate transporter) GLT-1 Onchocerca volvulus TR19244_c0_g1_i1 Q9CR42 ANKR1_MOUSE 2.00E-16 GO:0003677; GO:0031674; GO:0001105; GO:0055008; GO:0035690; GO:0071456; GO:0071347; GO:0071222; GO:0071260; GO:0071407; GO:0071560; GO:0071356; GO:0005829; GO:2000279; GO:0000122; GO:0005634; GO:0043517; GO:0043065; GO:0010976; GO:0050714; GO:0006357; GO:0035994; GO:0035914; GO:0003714; GO:0005667 "DNA binding; I band; RNA polymerase II transcription coactivator activity; cardiac muscle tissue morphogenesis; cellular response to drug; cellular response to hypoxia; cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to organic cyclic compound; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; cytosol; negative regulation of DNA biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of apoptotic process; positive regulation of neuron projection development; positive regulation of protein secretion; regulation of transcription from RNA polymerase II promoter; response to muscle stretch; skeletal muscle cell differentiation; transcription corepressor activity; transcription factor complex" IPR002110; IPR020683; Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) Ankrd1 Carp Mus musculus (Mouse) TR19246_c0_g1_i1 Q9BX70 BTBD2_HUMAN 6.00E-13 GO:0000932 Q7L5N1; P04637 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) TR19247_c2_g1_i1 Q5VWJ9 SNX30_HUMAN 1.00E-13 GO:0007154; GO:0005737; GO:0035091; GO:0015031 O95219 cell communication; cytoplasm; phosphatidylinositol binding; protein transport IPR004148; IPR001683; Sorting nexin-30 SNX30 Homo sapiens (Human) TR19248_c0_g1_i1 P17671 E75BC_DROME 2.00E-30 GO:0003677; GO:0019730; GO:0018990; GO:0035072; GO:0020037; GO:0004879; GO:0005634; GO:0048477; GO:0007553; GO:0043565; GO:0003707; GO:0004887; GO:0008270 "DNA binding; antimicrobial humoral response; ecdysis, chitin-based cuticle; ecdysone-mediated induction of salivary gland cell autophagic cell death; heme binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleus; oogenesis; regulation of ecdysteroid metabolic process; sequence-specific DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001728; IPR001628; IPR013088; "Ecdysone-induced protein 75B, isoforms C/D (E75-A) (Nuclear receptor subfamily 1 group D member 3, isoforms C/D)" Eip75B NR1D3 CG8127 Drosophila melanogaster (Fruit fly) TR19256_c1_g1_i1 Q9UN19 DAPP1_HUMAN 4.00E-40 GO:0005829; GO:0005547; GO:0043325; GO:0005886; GO:0004725; GO:0007165 "cytosol; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; plasma membrane; protein tyrosine phosphatase activity; signal transduction" IPR011993; IPR001849; IPR000980; Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa) DAPP1 BAM32 HSPC066 Homo sapiens (Human) TR19256_c1_g2_i1 A6X942 SH24B_MOUSE 1.00E-07 IPR000980; SH2 domain-containing protein 4B Sh2d4b Mus musculus (Mouse) TR19259_c1_g1_i1 P33527 MRP1_HUMAN 2.00E-57 GO:0005524; GO:0042626; GO:0005794; GO:0019369; GO:0009235; GO:0005887; GO:0006691; GO:0005634; GO:0042493 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; Golgi apparatus; arachidonic acid metabolic process; cobalamin metabolic process; integral to plasma membrane; leukotriene metabolic process; nucleus; response to drug" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP MRP1 Homo sapiens (Human) TR19264_c0_g1_i1 Q96RW7 HMCN1_HUMAN 2.00E-31 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR19265_c0_g1_i1 A8XAC6 BAF1_CAEBR 4.00E-11 GO:0003677; GO:0005634 DNA binding; nucleus IPR004122; Barrier-to-autointegration factor 1 baf-1 CBG10084 Caenorhabditis briggsae TR19267_c0_g2_i1 P0C6B8 SVEP1_RAT 4.00E-13 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) TR1927_c0_g1_i1 P80912 HINT1_RABIT 1.00E-52 GO:0005737; GO:0000118; GO:0016787; GO:0072332; GO:0000166; GO:0009154; GO:0006355; GO:0006351 "cytoplasm; histone deacetylase complex; hydrolase activity; intrinsic apoptotic signaling pathway by p53 class mediator; nucleotide binding; purine ribonucleotide catabolic process; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019808; IPR001310; IPR011146; Histidine triad nucleotide-binding protein 1 (EC 3.-.-.-) (Adenosine 5'-monophosphoramidase) (P13.7) HINT1 HINT Oryctolagus cuniculus (Rabbit) TR19281_c0_g1_i1 P98160 PGBM_HUMAN 7.00E-17 GO:0005796; GO:0001525; GO:0005605; GO:0007420; GO:0005975; GO:0048738; GO:0060351; GO:0002062; GO:0030204; GO:0048704; GO:0001958; GO:0030198; GO:0005615; GO:0070062; GO:0006024; GO:0006027; GO:0042157; GO:0043202; GO:0046872; GO:0007603; GO:0005886; GO:0008104; GO:0001523 P35968 "Golgi lumen; angiogenesis; basal lamina; brain development; carbohydrate metabolic process; cardiac muscle tissue development; cartilage development involved in endochondral bone morphogenesis; chondrocyte differentiation; chondroitin sulfate metabolic process; embryonic skeletal system morphogenesis; endochondral ossification; extracellular matrix organization; extracellular space; extracellular vesicular exosome; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; lipoprotein metabolic process; lysosomal lumen; metal ion binding; phototransduction, visible light; plasma membrane; protein localization; retinoid metabolic process" IPR008985; IPR013320; IPR000742; IPR013032; IPR002049; IPR007110; IPR013783; IPR013098; IPR003598; IPR018031; IPR000034; IPR001791; IPR023415; IPR002172; IPR000082; Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] HSPG2 Homo sapiens (Human) TR19281_c1_g1_i1 Q80YN4 CORIN_RAT 3.00E-11 GO:0016023; GO:0005576; GO:0007565; GO:0005887; GO:0016486; GO:0006508; GO:0035813; GO:0003050; GO:0005044; GO:0004252; GO:0070008 cytoplasmic membrane-bounded vesicle; extracellular region; female pregnancy; integral to plasma membrane; peptide hormone processing; proteolysis; regulation of renal sodium excretion; regulation of systemic arterial blood pressure by atrial natriuretic peptide; scavenger receptor activity; serine-type endopeptidase activity; serine-type exopeptidase activity IPR020067; IPR023415; IPR002172; IPR001254; IPR017052; IPR001190; IPR017448; IPR009003; "Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Pro-ANP-converting enzyme) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment]" Corin Rattus norvegicus (Rat) TR19281_c2_g3_i1 P14543 NID1_HUMAN 3.00E-50 GO:0005605; GO:0005509; GO:0071944; GO:0007160; GO:0050840; GO:0032836; GO:0010811 basal lamina; calcium ion binding; cell periphery; cell-matrix adhesion; extracellular matrix binding; glomerular basement membrane development; positive regulation of cell-substrate adhesion IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR006605; IPR009017; IPR023413; IPR009030; IPR000033; IPR003886; IPR000716; Nidogen-1 (NID-1) (Entactin) NID1 NID Homo sapiens (Human) TR19281_c4_g1_i1 Q7QIQ6 CUE_ANOGA 4.00E-08 GO:0030154; GO:0016021; GO:0048477; GO:0005886; GO:0007283 cell differentiation; integral to membrane; oogenesis; plasma membrane; spermatogenesis IPR011042; IPR000742; IPR013032; IPR000033; Protein cueball cue AGAP007023 Anopheles gambiae (African malaria mosquito) TR19281_c4_g2_i1 O75096 LRP4_HUMAN 4.00E-169 GO:0016055; GO:0005509; GO:0030154; GO:0009953; GO:0042733; GO:0006897; GO:0030198; GO:0001942; GO:0016021; GO:0001822; GO:0090090; GO:0030279; GO:0042475; GO:0005886; GO:0009954; GO:0043113; GO:0001932; GO:0051124 Wnt receptor signaling pathway; calcium ion binding; cell differentiation; dorsal/ventral pattern formation; embryonic digit morphogenesis; endocytosis; extracellular matrix organization; hair follicle development; integral to membrane; kidney development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of ossification; odontogenesis of dentin-containing tooth; plasma membrane; proximal/distal pattern formation; receptor clustering; regulation of protein phosphorylation; synaptic growth at neuromuscular junction IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) TR19281_c4_g4_i1 O75096 LRP4_HUMAN 1.00E-163 GO:0016055; GO:0005509; GO:0030154; GO:0009953; GO:0042733; GO:0006897; GO:0030198; GO:0001942; GO:0016021; GO:0001822; GO:0090090; GO:0030279; GO:0042475; GO:0005886; GO:0009954; GO:0043113; GO:0001932; GO:0051124 Wnt receptor signaling pathway; calcium ion binding; cell differentiation; dorsal/ventral pattern formation; embryonic digit morphogenesis; endocytosis; extracellular matrix organization; hair follicle development; integral to membrane; kidney development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of ossification; odontogenesis of dentin-containing tooth; plasma membrane; proximal/distal pattern formation; receptor clustering; regulation of protein phosphorylation; synaptic growth at neuromuscular junction IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) TR19281_c4_g5_i1 Q99088 LDLR2_XENLA 1.00E-63 GO:0005509; GO:0008203; GO:0005905; GO:0006897; GO:0016021; GO:0006869; GO:0034362 calcium ion binding; cholesterol metabolic process; coated pit; endocytosis; integral to membrane; lipid transport; low-density lipoprotein particle IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor 2 (LDL receptor 2) ldlr-b ldlr2 Xenopus laevis (African clawed frog) TR19281_c5_g1_i1 O95460 MATN4_HUMAN 6.00E-13 GO:0030198; GO:0005576; GO:0048678 extracellular matrix organization; extracellular region; response to axon injury IPR000742; IPR013032; IPR000152; IPR009030; IPR019466; IPR002035; Matrilin-4 MATN4 Homo sapiens (Human) TR19281_c8_g1_i1 P01131 LDLR_BOVIN 3.00E-24 GO:0005794; GO:0009986; GO:0008203; GO:0005905; GO:0005769; GO:0006897; GO:0016021; GO:0005770; GO:0006869; GO:0034362; GO:0005764; GO:0005886 Golgi apparatus; cell surface; cholesterol metabolic process; coated pit; early endosome; endocytosis; integral to membrane; late endosome; lipid transport; low-density lipoprotein particle; lysosome; plasma membrane IPR011042; IPR000742; IPR000033; Low-density lipoprotein receptor (LDL receptor) (Fragment) LDLR Bos taurus (Bovine) TR19289_c0_g2_i1 Q8K430 KLH17_RAT 6.00E-10 GO:0015629; GO:0030036; GO:0051015; GO:0007420; GO:0030054; GO:0032839; GO:0043025; GO:0014069; GO:0045211; GO:0032947; GO:0016567 P31016; Q9JJ40; Q9QUH6 actin cytoskeleton; actin cytoskeleton organization; actin filament binding; brain development; cell junction; dendrite cytoplasm; neuronal cell body; postsynaptic density; postsynaptic membrane; protein complex scaffold; protein ubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 17 (Actinfilin) Klhl17 Rattus norvegicus (Rat) TR19291_c0_g1_i1 Q9HC56 PCDH9_HUMAN 3.00E-17 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR013164; IPR013585; Protocadherin-9 PCDH9 Homo sapiens (Human) TR19291_c2_g1_i1 Q5DRB3 PCDG7_PANTR 5.00E-16 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR013164; Protocadherin gamma-A7 (PCDH-gamma-A7) PCDHGA7 Pan troglodytes (Chimpanzee) TR19293_c2_g1_i1 Q9ULJ7 ANR50_HUMAN 5.00E-17 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) TR19293_c4_g1_i1 Q6JAN1 INVS_CANFA 8.00E-12 GO:0016055; GO:0005737; GO:0060971; GO:0001822; GO:0016020; GO:0005874; GO:0090090; GO:0005634; GO:0031016; GO:0009791; GO:0005819 Wnt receptor signaling pathway; cytoplasm; embryonic heart tube left/right pattern formation; kidney development; membrane; microtubule; negative regulation of canonical Wnt receptor signaling pathway; nucleus; pancreas development; post-embryonic development; spindle IPR002110; IPR020683; IPR000048; Inversin (Inversion of embryo turning protein) (Nephrocystin-2) INVS INV NPHP2 Canis familiaris (Dog) (Canis lupus familiaris) TR19299_c1_g1_i1 O08726 GALR2_RAT 8.00E-09 GO:0007189; GO:0007204; GO:0004966; GO:0043647; GO:0016021; GO:0007194; GO:0042923; GO:0046488; GO:0005886 adenylate cyclase-activating G-protein coupled receptor signaling pathway; elevation of cytosolic calcium ion concentration; galanin receptor activity; inositol phosphate metabolic process; integral to membrane; negative regulation of adenylate cyclase activity; neuropeptide binding; phosphatidylinositol metabolic process; plasma membrane IPR003907; IPR000405; IPR000276; IPR017452; Galanin receptor type 2 (GAL2-R) (GALR-2) Galr2 Galnr2 Rattus norvegicus (Rat) TR19304_c0_g1_i1 Q8WWI1 LMO7_HUMAN 9.00E-31 GO:0005737; GO:0005634; GO:0000151; GO:0004842; GO:0008270 cytoplasm; nucleus; ubiquitin ligase complex; ubiquitin-protein ligase activity; zinc ion binding IPR001715; IPR001478; IPR003096; IPR001781; LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) LMO7 FBX20 FBXO20 KIAA0858 Homo sapiens (Human) TR19304_c0_g2_i1 Q9R0C8 VAV3_MOUSE 2.00E-08 GO:0050853; GO:0030676; GO:0001525; GO:0016477; GO:0005737; GO:0007229; GO:0030032; GO:0046872; GO:0005543; GO:0005886; GO:0030890; GO:0045785; GO:0043552; GO:0043087; GO:0035023; GO:0006974; GO:0042493; GO:0007264; GO:0006906 B cell receptor signaling pathway; Rac guanyl-nucleotide exchange factor activity; angiogenesis; cell migration; cytoplasm; integrin-mediated signaling pathway; lamellipodium assembly; metal ion binding; phospholipid binding; plasma membrane; positive regulation of B cell proliferation; positive regulation of cell adhesion; positive regulation of phosphatidylinositol 3-kinase activity; regulation of GTPase activity; regulation of Rho protein signal transduction; response to DNA damage stimulus; response to drug; small GTPase mediated signal transduction; vesicle fusion IPR022613; IPR001715; IPR000219; IPR001331; IPR011993; IPR001849; IPR002219; IPR000980; IPR011511; IPR001452; IPR003096; Guanine nucleotide exchange factor VAV3 (VAV-3) Vav3 Mus musculus (Mouse) TR19308_c1_g1_i1 P29702 FNTA_BOVIN 1.00E-59 GO:0004662; GO:0004660; GO:0018342 CAAX-protein geranylgeranyltransferase activity; protein farnesyltransferase activity; protein prenylation IPR002088; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) FNTA Bos taurus (Bovine) TR19308_c1_g2_i1 O24304 FNTA_PEA 2.00E-45 GO:0004662; GO:0004660; GO:0018342 CAAX-protein geranylgeranyltransferase activity; protein farnesyltransferase activity; protein prenylation IPR002088; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) FTA Pisum sativum (Garden pea) TR19315_c1_g1_i1 Q17QF9 CBLN3_BOVIN 7.00E-06 GO:0005794; GO:0030054; GO:0005783; GO:0005576; GO:0045202 Golgi apparatus; cell junction; endoplasmic reticulum; extracellular region; synapse IPR001073; IPR008983; Cerebellin-3 CBLN3 Bos taurus (Bovine) TR19316_c0_g2_i1 Q60989 XIAP_MOUSE 8.00E-22 GO:0016055; GO:0005737; GO:0005829; GO:1990001; GO:0043066; GO:0043524; GO:0051402; GO:0005634; GO:0048471; GO:0043234; GO:0004842; GO:0008270 P53702; Q9JIY5 Wnt receptor signaling pathway; cytoplasm; cytosol; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of neuron apoptotic process; neuron apoptotic process; nucleus; perinuclear region of cytoplasm; protein complex; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (mIAP-3) (mIAP3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) Xiap Aipa Api3 Birc4 Miha Mus musculus (Mouse) TR19317_c0_g1_i1 P22933 GBRD_MOUSE 6.00E-39 GO:0004890; GO:0030054; GO:0005254; GO:0034707; GO:0005230; GO:0045211; GO:0007268 GABA-A receptor activity; cell junction; chloride channel activity; chloride channel complex; extracellular ligand-gated ion channel activity; postsynaptic membrane; synaptic transmission IPR006028; IPR008098; IPR006202; IPR006201; IPR006029; IPR018000; Gamma-aminobutyric acid receptor subunit delta (GABA(A) receptor subunit delta) Gabrd Mus musculus (Mouse) TR19327_c0_g1_i1 P08548 LIN1_NYCCO 2.00E-06 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR19330_c0_g1_i1 Q1ENI8 PXDN_CAEEL 6.00E-08 GO:0005576; GO:0020037; GO:0042744; GO:0046872; GO:0004601 extracellular region; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR000372; Peroxidasin homolog (EC 1.11.1.7) pxn-1 ZK994.3 Caenorhabditis elegans TR19330_c0_g2_i1 P98160 PGBM_HUMAN 2.00E-15 GO:0005796; GO:0001525; GO:0005605; GO:0007420; GO:0005975; GO:0048738; GO:0060351; GO:0002062; GO:0030204; GO:0048704; GO:0001958; GO:0030198; GO:0005615; GO:0070062; GO:0006024; GO:0006027; GO:0042157; GO:0043202; GO:0046872; GO:0007603; GO:0005886; GO:0008104; GO:0001523 P35968 "Golgi lumen; angiogenesis; basal lamina; brain development; carbohydrate metabolic process; cardiac muscle tissue development; cartilage development involved in endochondral bone morphogenesis; chondrocyte differentiation; chondroitin sulfate metabolic process; embryonic skeletal system morphogenesis; endochondral ossification; extracellular matrix organization; extracellular space; extracellular vesicular exosome; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; lipoprotein metabolic process; lysosomal lumen; metal ion binding; phototransduction, visible light; plasma membrane; protein localization; retinoid metabolic process" IPR008985; IPR013320; IPR000742; IPR013032; IPR002049; IPR007110; IPR013783; IPR013098; IPR003598; IPR018031; IPR000034; IPR001791; IPR023415; IPR002172; IPR000082; Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] HSPG2 Homo sapiens (Human) TR19330_c1_g1_i1 Q96RW7 HMCN1_HUMAN 9.00E-12 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR19330_c1_g2_i1 Q1LUA6 TRIO_DANRE 3.00E-06 GO:0005524; GO:0005089; GO:0005737; GO:0005543; GO:0004674; GO:0035023 ATP binding; Rho guanyl-nucleotide exchange factor activity; cytoplasm; phospholipid binding; protein serine/threonine kinase activity; regulation of Rho protein signal transduction IPR001251; IPR000219; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR017441; IPR002290; IPR008271; IPR001452; IPR018159; IPR002017; Triple functional domain protein (EC 2.7.11.1) trio si:dkey-158b13.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR19348_c0_g1_i1 Q68EA5 ZNF57_HUMAN 2.00E-11 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 57 (Zinc finger protein 424) ZNF57 ZNF424 Homo sapiens (Human) TR19349_c2_g1_i1 Q8UUZ1 MB212_DANRE 3.00E-14 GO:0048048; GO:0005634 embryonic eye morphogenesis; nucleus IPR024810; IPR024801; IPR000772; Protein mab-21-like 2 mab21l2 Danio rerio (Zebrafish) (Brachydanio rerio) TR19351_c1_g1_i1 Q5SPH9 RT10_DANRE 6.00E-06 GO:0005739; GO:0005840; GO:0003735; GO:0006412 mitochondrion; ribosome; structural constituent of ribosome; translation IPR001848; IPR027486; "Probable 28S ribosomal protein S10, mitochondrial (MRP-S10) (S10mt)" mrps10 im:6911513 si:ch211-51e12.6 Danio rerio (Zebrafish) (Brachydanio rerio) TR19351_c1_g1_i2 Q8JZS9 RM48_MOUSE 2.00E-11 GO:0005761 mitochondrial ribosome IPR027487; IPR027486; "39S ribosomal protein L48, mitochondrial (L48mt) (MRP-L48)" Mrpl48 Mus musculus (Mouse) TR19352_c0_g1_i1 O61462 RL37A_CRYST 1.00E-49 GO:0046872; GO:0005840; GO:0003735; GO:0006412 metal ion binding; ribosome; structural constituent of ribosome; translation IPR002674; IPR011331; IPR011332; 60S ribosomal protein L37a RPL37A Cryptochiton stelleri (Giant gumboot chiton) TR19354_c0_g2_i1 B0S6R1 NCKP1_DANRE 2.00E-19 GO:0016021; GO:0031258 integral to membrane; lamellipodium membrane IPR019137; Nck-associated protein 1 (NAP 1) nckap1 si:dkey-234n3.1 wu:fd05c01 Danio rerio (Zebrafish) (Brachydanio rerio) TR19356_c0_g1_i1 P80090 MPI3_LYMST 3.00E-08 GO:0005576; GO:0030133 extracellular region; transport vesicle IPR016179; IPR016724; IPR022353; IPR022352; Molluscan insulin-related peptide 3 (MIP III) [Cleaved into: Molluscan insulin-related peptide 3 B chain; Molluscan insulin-related peptide 3 A chain] Lymnaea stagnalis (Great pond snail) TR19358_c1_g2_i1 Q5U3C3 TM164_HUMAN 2.00E-41 GO:0016021 integral to membrane IPR026508; Transmembrane protein 164 TMEM164 Homo sapiens (Human) TR1936_c0_g1_i1 P10073 ZSC22_HUMAN 8.00E-18 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 22 (Krueppel-related zinc finger protein 2) (Protein HKR2) (Zinc finger protein 50) ZSCAN22 HKR2 ZNF50 Homo sapiens (Human) TR1936_c0_g2_i1 P51774 EGR2_RAT 1.00E-12 GO:0071320; GO:0071371; GO:0003682; GO:0005737; GO:0045444; GO:0007611; GO:0016874; GO:0046872; GO:0042552; GO:0043066; GO:0005634; GO:0045893; GO:0006611; GO:0016925; GO:0048168; GO:0032868; GO:0003700; GO:0035914; GO:0006366; GO:0044212 "cellular response to cAMP; cellular response to gonadotropin stimulus; chromatin binding; cytoplasm; fat cell differentiation; learning or memory; ligase activity; metal ion binding; myelination; negative regulation of apoptotic process; nucleus; positive regulation of transcription, DNA-dependent; protein export from nucleus; protein sumoylation; regulation of neuronal synaptic plasticity; response to insulin stimulus; sequence-specific DNA binding transcription factor activity; skeletal muscle cell differentiation; transcription from RNA polymerase II promoter; transcription regulatory region DNA binding" IPR021849; IPR007087; IPR015880; IPR013087; Protein modification; protein sumoylation. E3 SUMO-protein ligase EGR2 (EC 6.3.2.-) (Early growth response protein 2) (EGR-2) (Zinc finger protein Krox-20) Egr2 Egr-2 Krox-20 Krox20 Rattus norvegicus (Rat) TR19367_c1_g2_i1 Q9Z336 DYLT1_RAT 2.00E-55 GO:0005794; GO:0051301; GO:0005868; GO:0000132; GO:0006886; GO:0019060; GO:0005874; GO:0007067; GO:0003774; GO:0050768; GO:0048812; GO:0008277; GO:0032314; GO:0051493; GO:0005819 Q62968 Golgi apparatus; cell division; cytoplasmic dynein complex; establishment of mitotic spindle orientation; intracellular protein transport; intracellular transport of viral proteins in host cell; microtubule; mitosis; motor activity; negative regulation of neurogenesis; neuron projection morphogenesis; regulation of G-protein coupled receptor protein signaling pathway; regulation of Rac GTPase activity; regulation of cytoskeleton organization; spindle IPR005334; Dynein light chain Tctex-type 1 (Activator of G-protein signaling 2) (AGS2) (T-complex testis-specific protein 1 homolog) Dynlt1 Tctel1 Tctex-1 Tctex1 Rattus norvegicus (Rat) TR19368_c0_g1_i1 P50238 CRIP1_HUMAN 6.00E-36 GO:0003680; GO:0008301; GO:0008283; GO:0071493; GO:0071236; GO:0005737; GO:0007507; GO:0006955; GO:0008630; GO:0042277; GO:0060741; GO:0010468; GO:0010033; GO:0010043; GO:0008270 "AT DNA binding; DNA binding, bending; cell proliferation; cellular response to UV-B; cellular response to antibiotic; cytoplasm; heart development; immune response; intrinsic apoptotic signaling pathway in response to DNA damage; peptide binding; prostate gland stromal morphogenesis; regulation of gene expression; response to organic substance; response to zinc ion; zinc ion binding" IPR001781; Cysteine-rich protein 1 (CRP-1) (Cysteine-rich heart protein) (CRHP) (hCRHP) (Cysteine-rich intestinal protein) (CRIP) CRIP1 CRIP CRP1 Homo sapiens (Human) TR19369_c0_g1_i1 Q6P069 SORCN_MOUSE 3.00E-27 GO:0030018; GO:0005509; GO:0006816; GO:0042584; GO:0042994; GO:0005829; GO:0010459; GO:0060315; GO:2000678; GO:0005886; GO:0035774; GO:0051281; GO:0086004; GO:1901844; GO:1901841; GO:1901077; GO:0033017; GO:0031982 Z disc; calcium ion binding; calcium ion transport; chromaffin granule membrane; cytoplasmic sequestering of transcription factor; cytosol; negative regulation of heart rate; negative regulation of ryanodine-sensitive calcium-release channel activity; negative regulation of transcription regulatory region DNA binding; plasma membrane; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of release of sequestered calcium ion into cytosol; regulation of cardiac muscle cell contraction; regulation of cell communication by electrical coupling involved in cardiac conduction; regulation of high voltage-gated calcium channel activity; regulation of relaxation of muscle; sarcoplasmic reticulum membrane; vesicle IPR011992; IPR018247; IPR002048; Sorcin Sri Mus musculus (Mouse) TR19372_c4_g1_i2 Q3UIR3 DTX3L_MOUSE 1.00E-26 GO:0005737; GO:0006302; GO:0042393; GO:0010390; GO:0005634; GO:0004842; GO:0008270 cytoplasm; double-strand break repair; histone binding; histone monoubiquitination; nucleus; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (Protein deltex-3-like) Dtx3l Bbap Mus musculus (Mouse) TR19377_c0_g1_i1 Q1JP63 SVOP_BOVIN 3.00E-37 GO:0030054; GO:0016021; GO:0015075; GO:0030672 cell junction; integral to membrane; ion transmembrane transporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; IPR004749; IPR005828; Synaptic vesicle 2-related protein (SV2-related protein) SVOP Bos taurus (Bovine) TR19382_c0_g1_i1 P08169 MPRI_BOVIN 2.00E-35 GO:0009986; GO:0030139; GO:0001948; GO:0016021; GO:0005765; GO:0051219; GO:0005215 cell surface; endocytic vesicle; glycoprotein binding; integral to membrane; lysosomal membrane; phosphoprotein binding; transporter activity IPR000479; IPR000562; IPR013806; IPR009011; Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (CD antigen CD222) IGF2R M6P Bos taurus (Bovine) TR19385_c1_g1_i1 Q29122 MYO6_PIG 3.00E-38 GO:0043531; GO:0005524; GO:0030330; GO:0016591; GO:0005794; GO:0051015; GO:0030048; GO:0005516; GO:0005938; GO:0016023; GO:0006897; GO:0031941; GO:0006886; GO:0003774; GO:0016459; GO:0031965; GO:0048471; GO:0045944; GO:0051046; GO:0001726; GO:0007605 "ADP binding; ATP binding; DNA damage response, signal transduction by p53 class mediator; DNA-directed RNA polymerase II, holoenzyme; Golgi apparatus; actin filament binding; actin filament-based movement; calmodulin binding; cell cortex; cytoplasmic membrane-bounded vesicle; endocytosis; filamentous actin; intracellular protein transport; motor activity; myosin complex; nuclear membrane; perinuclear region of cytoplasm; positive regulation of transcription from RNA polymerase II promoter; regulation of secretion; ruffle; sensory perception of sound" IPR000048; IPR001609; IPR027417; Unconventional myosin-VI (Unconventional myosin-6) MYO6 Sus scrofa (Pig) TR19388_c0_g1_i1 O86034 BDHA_RHIME 1.00E-48 GO:0003858 3-hydroxybutyrate dehydrogenase activity IPR011294; IPR002198; IPR002347; IPR016040; IPR020904; D-beta-hydroxybutyrate dehydrogenase (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (3-HBDH) bdhA RB1136 SMb21010 Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) TR19392_c1_g1_i1 Q9UPU5 UBP24_HUMAN 4.00E-11 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR016024; IPR018200; IPR001394; IPR009060; IPR015940; Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) USP24 KIAA1057 Homo sapiens (Human) TR19395_c0_g1_i1 O15116 LSM1_HUMAN 4.00E-52 GO:0003723; GO:0000375; GO:0005829; GO:0043928; GO:0071044; GO:0006397; GO:0005634; GO:0030529 Q9Y333; P62310 "RNA binding; RNA splicing, via transesterification reactions; cytosol; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; histone mRNA catabolic process; mRNA processing; nucleus; ribonucleoprotein complex" IPR010920; IPR001163; IPR006649; U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm) LSM1 CASM Homo sapiens (Human) TR19396_c0_g1_i1 Q6PC91 BT3L4_DANRE 3.00E-53 IPR002715; Transcription factor BTF3 homolog 4 (Basic transcription factor 3-like 4) btf3l4 Danio rerio (Zebrafish) (Brachydanio rerio) TR19399_c1_g1_i1 Q8KQN8 CPHE_PSEAG 3.00E-10 GO:0044260; GO:0005576; GO:0006508; GO:0008236 cellular macromolecule metabolic process; extracellular region; proteolysis; serine-type peptidase activity IPR005320; IPR011811; Cyanophycinase (EC 3.4.15.6) (Extracellular CGPase) (CPHEpa) (Extracellular cyanophycinase) cphE Pseudomonas anguilliseptica TR1940_c0_g1_i1 Q1HPL8 NDUBA_BOMMO 2.00E-45 GO:0005743; GO:0055114; GO:0070469 mitochondrial inner membrane; oxidation-reduction process; respiratory chain IPR019377; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 Bombyx mori (Silk moth) TR19400_c0_g1_i1 P60623 CRVP_TRIST 4.00E-23 GO:0005576 extracellular region IPR001283; IPR018244; IPR014044; IPR013871; IPR003582; IPR002413; Cysteine-rich venom protein (CRVP) (Cysteine-rich secretory protein) (Stecrisp) (Fragment) Trimeresurus stejnegeri (Chinese green tree viper) (Viridovipera stejnegeri) TR19405_c2_g2_i1 Q0IP28 LAC25_ORYSJ 9.00E-21 GO:0048046; GO:0005507; GO:0052716; GO:0046274 apoplast; copper ion binding; hydroquinone:oxygen oxidoreductase activity; lignin catabolic process IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; IPR017761; Laccase-25 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 25) (Diphenol oxidase 25) (Urishiol oxidase 25) LAC25 Os12g0259800 LOC_Os12g15920 Oryza sativa subsp. japonica (Rice) TR19412_c0_g1_i1 Q9TTF0 NR2E3_BOVIN 1.00E-55 GO:0005634; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Photoreceptor-specific nuclear receptor (Nuclear receptor subfamily 2 group E member 3) (Retina-specific nuclear receptor) NR2E3 Bos taurus (Bovine) TR19413_c0_g1_i1 Q90660 BIR_CHICK 1.00E-11 GO:0006915; GO:0005737; GO:0043066; GO:0005634; GO:0008270 apoptotic process; cytoplasm; negative regulation of apoptotic process; nucleus; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Inhibitor of apoptosis protein (IAP) (Inhibitor of T-cell apoptosis protein) ITA IAP1 Gallus gallus (Chicken) TR19417_c3_g1_i1 Q8C0I1 ADAS_MOUSE 2.00E-06 GO:0071949; GO:0008762; GO:0008609; GO:0008611; GO:0005739; GO:0005778 FAD binding; UDP-N-acetylmuramate dehydrogenase activity; alkylglycerone-phosphate synthase activity; ether lipid biosynthetic process; mitochondrion; peroxisomal membrane IPR025650; IPR016169; IPR016166; IPR016167; IPR016164; IPR004113; IPR006094; Glycerolipid metabolism; ether lipid biosynthesis. "Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Alkylglycerone-phosphate synthase)" Agps Mus musculus (Mouse) TR19417_c3_g2_i2 A1L258 D2HDH_DANRE 2.00E-157 GO:0008762; GO:0050660; GO:0005739 UDP-N-acetylmuramate dehydrogenase activity; flavin adenine dinucleotide binding; mitochondrion IPR016169; IPR016166; IPR016167; IPR016164; IPR004113; IPR006094; IPR016171; "D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.-)" d2hgdh zgc:158661 Danio rerio (Zebrafish) (Brachydanio rerio) TR19417_c3_g3_i1 A1L258 D2HDH_DANRE 1.00E-88 GO:0008762; GO:0050660; GO:0005739 UDP-N-acetylmuramate dehydrogenase activity; flavin adenine dinucleotide binding; mitochondrion IPR016169; IPR016166; IPR016167; IPR016164; IPR004113; IPR006094; IPR016171; "D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.-)" d2hgdh zgc:158661 Danio rerio (Zebrafish) (Brachydanio rerio) TR19418_c1_g1_i1 A8DZE7 D42E1_DANRE 1.00E-11 GO:0003854; GO:0016021; GO:0006694 3-beta-hydroxy-delta5-steroid dehydrogenase activity; integral to membrane; steroid biosynthetic process IPR002225; IPR016040; Short-chain dehydrogenase/reductase family 42E member 1 (EC 1.1.1.-) sdr42e1 si:ch211-79l17.4 zgc:123280 Danio rerio (Zebrafish) (Brachydanio rerio) TR19420_c0_g2_i1 P10394 POL4_DROME 2.00E-21 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR19423_c0_g1_i1 Q6GP52 BECN1_XENLA 5.00E-175 GO:0000139; GO:0006914; GO:0000910; GO:0051607 Golgi membrane; autophagy; cytokinesis; defense response to virus IPR007243; Beclin-1 becn1 Xenopus laevis (African clawed frog) TR19424_c1_g1_i1 P23500 MRS4_YEAST 4.00E-06 GO:0016021; GO:0005381; GO:0006397; GO:0005743; GO:0048250 integral to membrane; iron ion transmembrane transporter activity; mRNA processing; mitochondrial inner membrane; mitochondrial iron ion transport IPR002067; IPR018108; IPR023395; Mitochondrial RNA-splicing protein MRS4 MRS4 YKR052C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR19424_c2_g1_i1 Q7T292 MFRN2_DANRE 5.00E-25 GO:0016021; GO:0006811; GO:0055072; GO:0005743 integral to membrane; ion transport; iron ion homeostasis; mitochondrial inner membrane IPR018108; IPR023395; Mitoferrin-2 (Mitochondrial iron transporter 2) (Solute carrier family 25 member 28) slc25a28 mfrn2 zgc:64212 Danio rerio (Zebrafish) (Brachydanio rerio) TR19426_c3_g1_i1 Q8MJC3 CASP3_RABIT 1.00E-34 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Oryctolagus cuniculus (Rabbit) TR19427_c0_g1_i1 P28494 MA2A1_RAT 8.00E-78 GO:0000139; GO:0004572; GO:0006486; GO:0008270 "Golgi membrane; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity; protein glycosylation; zinc ion binding" IPR011330; IPR027291; IPR015341; IPR000602; Protein modification; protein glycosylation. "Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) (Fragment)" Man2a1 Mana2 Rattus norvegicus (Rat) TR19435_c1_g1_i1 P38657 PDIA3_BOVIN 4.00E-73 GO:0045454; GO:0005783; GO:0005788; GO:0006662; GO:0042470; GO:0043065; GO:0003756; GO:0015035; GO:0006457 cell redox homeostasis; endoplasmic reticulum; endoplasmic reticulum lumen; glycerol ether metabolic process; melanosome; positive regulation of apoptotic process; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; protein folding IPR005788; IPR005792; IPR005746; IPR012336; IPR017937; IPR013766; Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) PDIA3 GRP58 Bos taurus (Bovine) TR19438_c4_g1_i1 A5HK05 APBP2_RAT 5.00E-15 GO:0030659; GO:0046907; GO:0005874; GO:0005634; GO:0015031 cytoplasmic vesicle membrane; intracellular transport; microtubule; nucleus; protein transport IPR013026; IPR011990; IPR019734; Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) Appbp2 Rattus norvegicus (Rat) TR19443_c0_g1_i1 O50655 XERD_SELRU 2.00E-09 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR19448_c2_g1_i1 Q54YF7 MANB_DICDI 3.00E-07 GO:0004559; GO:0030246; GO:0005576; GO:0006013; GO:0008270 alpha-mannosidase activity; carbohydrate binding; extracellular region; mannose metabolic process; zinc ion binding IPR011013; IPR011330; IPR013780; IPR027291; IPR011682; IPR015341; IPR000602; Alpha-mannosidase B (EC 3.2.1.24) manB DDB_G0278259 Dictyostelium discoideum (Slime mold) TR19448_c2_g1_i2 P28494 MA2A1_RAT 4.00E-25 GO:0000139; GO:0004572; GO:0006486; GO:0008270 "Golgi membrane; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity; protein glycosylation; zinc ion binding" IPR011330; IPR027291; IPR015341; IPR000602; Protein modification; protein glycosylation. "Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) (Fragment)" Man2a1 Mana2 Rattus norvegicus (Rat) TR19451_c0_g1_i1 Q5EAJ7 MVP_STRPU 0 GO:0005737; GO:0005634; GO:0030529 cytoplasm; nucleus; ribonucleoprotein complex IPR000048; IPR021870; IPR002499; Major vault protein (MVP) MVP Strongylocentrotus purpuratus (Purple sea urchin) TR19452_c2_g1_i1 Q8N8M0 NAT16_HUMAN 3.00E-08 GO:0008080 N-acetyltransferase activity IPR016181; IPR000182; Putative N-acetyltransferase 16 (EC 2.3.1.-) NAT16 C7orf52 Homo sapiens (Human) TR19454_c0_g2_i1 Q2IBC1 CAV1_RHIFE 4.00E-31 GO:0000139; GO:0031295; GO:0005901; GO:0005768 Golgi membrane; T cell costimulation; caveola; endosome IPR001612; IPR015504; IPR018361; Caveolin-1 CAV1 Rhinolophus ferrumequinum (Greater horseshoe bat) TR19456_c0_g2_i1 Q92081 ACES_MYXGL 9.00E-23 GO:0003990; GO:0004091; GO:0030054; GO:0005576; GO:0042135; GO:0005886; GO:0045202 acetylcholinesterase activity; carboxylesterase activity; cell junction; extracellular region; neurotransmitter catabolic process; plasma membrane; synapse IPR002018; IPR019826; IPR000997; Acetylcholinesterase (AChE) (EC 3.1.1.7) (Fragment) ache ace1 Myxine glutinosa (Atlantic hagfish) TR19460_c1_g1_i1 Q11002 CANA_DROME 8.00E-66 GO:0021919; GO:0015629; GO:0005509; GO:0004198; GO:0042335; GO:0005737; GO:0008340; GO:0043025; GO:0006909; GO:0016540; GO:0006508 BMP signaling pathway involved in spinal cord dorsal/ventral patterning; actin cytoskeleton; calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cuticle development; cytoplasm; determination of adult lifespan; neuronal cell body; phagocytosis; protein autoprocessing; proteolysis IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-A (EC 3.4.22.-) (Calcium-activated neutral proteinase A) (CANP A) [Cleaved into: Calpain-A catalytic subunit] CalpA CG7563 Drosophila melanogaster (Fruit fly) TR19461_c0_g2_i1 Q923S9 RAB30_MOUSE 8.00E-09 GO:0005525; GO:0031985; GO:0007030; GO:0005801; GO:0016020; GO:0015031; GO:0007264; GO:0005802 GTP binding; Golgi cisterna; Golgi organization; cis-Golgi network; membrane; protein transport; small GTPase mediated signal transduction; trans-Golgi network IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-30 Rab30 Rsb30 Mus musculus (Mouse) TR19462_c0_g1_i1 Q9H3S7 PTN23_HUMAN 8.00E-61 GO:0005929; GO:0060271; GO:0016023; GO:0005769; GO:0005932; GO:0005634; GO:0035335; GO:0015031; GO:0004725; GO:0043162 Q9H444; O75791; O89100; P62993; O75340; Q05397; Q99962; Q99816 cilium; cilium morphogenesis; cytoplasmic membrane-bounded vesicle; early endosome; microtubule basal body; nucleus; peptidyl-tyrosine dephosphorylation; protein transport; protein tyrosine phosphatase activity; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IPR025304; IPR004328; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) PTPN23 KIAA1471 Homo sapiens (Human) TR19462_c1_g1_i1 O88902 PTN23_RAT 5.00E-14 GO:0005929; GO:0060271; GO:0016023; GO:0005769; GO:0005932; GO:0005634; GO:0035335; GO:0015031; GO:0004725; GO:0043162 cilium; cilium morphogenesis; cytoplasmic membrane-bounded vesicle; early endosome; microtubule basal body; nucleus; peptidyl-tyrosine dephosphorylation; protein transport; protein tyrosine phosphatase activity; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IPR025304; IPR004328; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) (Fragment) Ptpn23 Rattus norvegicus (Rat) TR19464_c1_g1_i1 O60911 CATL2_HUMAN 1.00E-72 GO:0060008; GO:0004177; GO:0019886; GO:0048102; GO:0009267; GO:0004197; GO:0046697; GO:0009897; GO:0022617; GO:0005576; GO:0043202; GO:0005902; GO:0010259; GO:0021675; GO:0043005; GO:0042277; GO:0043204; GO:0006508; GO:0051384; GO:0009749; GO:0034698; GO:0007283 Sertoli cell differentiation; aminopeptidase activity; antigen processing and presentation of exogenous peptide antigen via MHC class II; autophagic cell death; cellular response to starvation; cysteine-type endopeptidase activity; decidualization; external side of plasma membrane; extracellular matrix disassembly; extracellular region; lysosomal lumen; microvillus; multicellular organismal aging; nerve development; neuron projection; peptide binding; perikaryon; proteolysis; response to glucocorticoid stimulus; response to glucose stimulus; response to gonadotropin stimulus; spermatogenesis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L2 (EC 3.4.22.43) (Cathepsin U) (Cathepsin V) CTSV CATL2 CTSL2 CTSU UNQ268/PRO305 Homo sapiens (Human) TR19464_c2_g1_i1 P05993 PAPA5_CARPA 1.00E-10 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR025661; IPR025660; IPR013128; IPR000668; Cysteine proteinase (EC 3.4.22.-) (Clone PLBPC13) (Fragment) Carica papaya (Papaya) TR19470_c0_g1_i1 Q6R5N8 TLR13_MOUSE 9.00E-30 GO:0002755; GO:0005768; GO:0010008; GO:0006954; GO:0045087; GO:0016021; GO:0042803; GO:0019843; GO:0043408; GO:0002237; GO:0009615; GO:0034178; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; endosome; endosome membrane; inflammatory response; innate immune response; integral to membrane; protein homodimerization activity; rRNA binding; regulation of MAPK cascade; response to molecule of bacterial origin; response to virus; toll-like receptor 13 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR003591; IPR000157; IPR027196; Toll-like receptor 13 Tlr13 Mus musculus (Mouse) TR19470_c0_g1_i2 Q68Y56 TLR4_PIG 1.00E-25 GO:0002755; GO:0050829; GO:0032497; GO:0006954; GO:0045087; GO:0001875; GO:0046696; GO:0042116; GO:0050707; GO:0034142; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-negative bacterium; detection of lipopolysaccharide; inflammatory response; innate immune response; lipopolysaccharide receptor activity; lipopolysaccharide receptor complex; macrophage activation; regulation of cytokine secretion; toll-like receptor 4 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR000157; IPR027168; IPR017241; Toll-like receptor 4 (CD antigen CD284) TLR4 Sus scrofa (Pig) TR19476_c1_g1_i1 Q9Z265 CHK2_MOUSE 2.00E-144 GO:0005524; GO:0006975; GO:0000086; GO:0016605; GO:0051301; GO:0006302; GO:0008630; GO:0046872; GO:0045893; GO:0046777; GO:0042803; GO:0004674; GO:0042176; GO:0010332; GO:0072428; GO:0090307; GO:0006351 "ATP binding; DNA damage induced protein phosphorylation; G2/M transition of mitotic cell cycle; PML body; cell division; double-strand break repair; intrinsic apoptotic signaling pathway in response to DNA damage; metal ion binding; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein homodimerization activity; protein serine/threonine kinase activity; regulation of protein catabolic process; response to gamma radiation; signal transduction involved in intra-S DNA damage checkpoint; spindle assembly involved in mitosis; transcription, DNA-dependent" IPR000253; IPR011009; IPR000719; IPR002290; IPR008271; IPR008984; Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Checkpoint kinase 2) Chek2 Chk2 Rad53 Mus musculus (Mouse) TR19477_c1_g1_i1 P27046 MA2A1_MOUSE 2.00E-56 GO:0000139; GO:0006491; GO:0030246; GO:0005801; GO:0016799; GO:0001701; GO:0016021; GO:0001889; GO:0048286; GO:0006013; GO:0015923; GO:0004572; GO:0007005; GO:0050769; GO:0007585; GO:0060042; GO:0007033; GO:0008270 "Golgi membrane; N-glycan processing; carbohydrate binding; cis-Golgi network; hydrolase activity, hydrolyzing N-glycosyl compounds; in utero embryonic development; integral to membrane; liver development; lung alveolus development; mannose metabolic process; mannosidase activity; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity; mitochondrion organization; positive regulation of neurogenesis; respiratory gaseous exchange; retina morphogenesis in camera-type eye; vacuole organization; zinc ion binding" IPR011013; IPR011330; IPR013780; IPR027291; IPR011682; IPR015341; IPR000602; Protein modification; protein glycosylation. "Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)" Man2a1 Mana2 Mus musculus (Mouse) TR19485_c0_g1_i1 Q60HE9 MA2B1_MACFA 4.00E-11 GO:0004559; GO:0030246; GO:0005764; GO:0006013; GO:0008270 alpha-mannosidase activity; carbohydrate binding; lysosome; mannose metabolic process; zinc ion binding IPR011013; IPR011330; IPR013780; IPR027291; IPR011682; IPR015341; IPR000602; Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) MAN2B1 QmoA-10471 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR19486_c0_g1_i2 Q8NB14 UBP38_HUMAN 4.00E-19 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.4.19.12) (Deubiquitinating enzyme 38) (HP43.8KD) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38) USP38 KIAA1891 Homo sapiens (Human) TR19486_c0_g1_i3 Q9P2H5 UBP35_HUMAN 5.00E-18 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR016024; IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.4.19.12) (Deubiquitinating enzyme 35) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35) USP35 KIAA1372 USP34 Homo sapiens (Human) TR19489_c1_g1_i1 Q2KIR7 GLYAT_BOVIN 1.00E-11 GO:0047961; GO:0047962; GO:0006544; GO:0005739; GO:0032787; GO:0009636 glycine N-acyltransferase activity; glycine N-benzoyltransferase activity; glycine metabolic process; mitochondrion; monocarboxylic acid metabolic process; response to toxic substance IPR016181; IPR010313; IPR013652; IPR015938; Glycine N-acyltransferase (EC 2.3.1.13) (EC 2.3.1.71) (Acyl-CoA:glycine N-acyltransferase) (AAc) (Aralkyl acyl-CoA N-acyltransferase) (Aralkyl acyl-CoA:amino acid N-acyltransferase) (Benzoyl-coenzyme A:glycine N-acyltransferase) (Glycine N-benzoyltransferase) GLYAT Bos taurus (Bovine) TR19490_c0_g1_i2 A3KQV2 BROX_DANRE 4.00E-84 GO:0016020 membrane IPR004328; BRO1 domain-containing protein BROX (BRO1 domain- and CAAX motif-containing protein) brox si:ch211-14a11.3 zgc:101706 Danio rerio (Zebrafish) (Brachydanio rerio) TR19492_c1_g1_i1 Q08999 RBL2_HUMAN 5.00E-68 GO:0003677; GO:0016568; GO:0005737; GO:0000278; GO:0005730; GO:0005654; GO:0051726; GO:0043550; GO:0006357; GO:0005667; GO:0006351 P03255; Q13574-2; Q6MZP7; P24610; P67775; Q923E4; Q61412 "DNA binding; chromatin modification; cytoplasm; mitotic cell cycle; nucleolus; nucleoplasm; regulation of cell cycle; regulation of lipid kinase activity; regulation of transcription from RNA polymerase II promoter; transcription factor complex; transcription, DNA-dependent" IPR013763; IPR028308; IPR002720; IPR002719; IPR028309; IPR024599; Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) RBL2 RB2 Homo sapiens (Human) TR19492_c2_g1_i1 P28749 RBL1_HUMAN 2.00E-86 GO:0016568; GO:0000278; GO:0019048; GO:0000122; GO:0005654; GO:0045944; GO:0051726; GO:0043550; GO:0005667; GO:0006367; GO:0007179 P03255; Q9BUH8; P11802; Q13574-2; Q7L2E3; Q13627; Q9Y463; Q14653; Q9Y5X4; P24610; P67775; Q923E4 chromatin modification; mitotic cell cycle; modulation by virus of host morphology or physiology; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; regulation of cell cycle; regulation of lipid kinase activity; transcription factor complex; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway IPR013763; IPR002720; IPR002719; IPR015030; IPR028309; IPR024599; IPR028310; Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) RBL1 Homo sapiens (Human) TR19494_c3_g1_i1 Q86VS3 IQCH_HUMAN 2.00E-47 IPR000048; IQ domain-containing protein H (Testis development protein NYD-SP5) IQCH Homo sapiens (Human) TR19497_c0_g1_i1 P0CB80 NDUA2_PONPY 3.00E-31 GO:0005743; GO:0055114; GO:0070469 mitochondrial inner membrane; oxidation-reduction process; respiratory chain IPR016464; IPR007741; IPR012336; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (Complex I-B8) (CI-B8) (NADH-ubiquinone oxidoreductase B8 subunit) NDUFA2 Pongo pygmaeus (Bornean orangutan) TR1950_c0_g1_i1 P46937 YAP1_HUMAN 2.00E-06 GO:0001076; GO:0008283; GO:0071480; GO:0003682; GO:0060242; GO:0005829; GO:0003143; GO:0035329; GO:0030216; GO:0048368; GO:0043066; GO:0030857; GO:0030903; GO:0005654; GO:0048339; GO:0090263; GO:0008284; GO:0046622; GO:0045944; GO:0010837; GO:0072091; GO:0006974; GO:0035019; GO:0003713; GO:0003714; GO:0005667; GO:0006367; GO:0044212; GO:0001570 P35222; O95835; Q15797; Q99593; P28347; Q13625-2; O15350-1; P97764; P31946; P63104 RNA polymerase II transcription factor binding transcription factor activity; cell proliferation; cellular response to gamma radiation; chromatin binding; contact inhibition; cytosol; embryonic heart tube morphogenesis; hippo signaling cascade; keratinocyte differentiation; lateral mesoderm development; negative regulation of apoptotic process; negative regulation of epithelial cell differentiation; notochord development; nucleoplasm; paraxial mesoderm development; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell proliferation; positive regulation of organ growth; positive regulation of transcription from RNA polymerase II promoter; regulation of keratinocyte proliferation; regulation of stem cell proliferation; response to DNA damage stimulus; somatic stem cell maintenance; transcription coactivator activity; transcription corepressor activity; transcription factor complex; transcription initiation from RNA polymerase II promoter; transcription regulatory region DNA binding; vasculogenesis IPR001202; Yorkie homolog (65 kDa Yes-associated protein) (YAP65) YAP1 YAP65 Homo sapiens (Human) TR19503_c0_g1_i1 Q1L9A2 OPA3_DANRE 2.00E-14 GO:0007626; GO:0005739; GO:0050881; GO:0031413 locomotory behavior; mitochondrion; musculoskeletal movement; regulation of buoyancy IPR010754; Optic atrophy 3 protein homolog opa3 si:dkey-12o15.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR19504_c1_g1_i1 O43795 MYO1B_HUMAN 5.00E-14 GO:0005524; GO:0051017; GO:0030048; GO:0005903; GO:0005737; GO:0030175; GO:0000146; GO:0016459; GO:0005547; GO:0005546; GO:0005886 "ATP binding; actin filament bundle assembly; actin filament-based movement; brush border; cytoplasm; filopodium; microfilament motor activity; myosin complex; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; plasma membrane" IPR000048; IPR001609; IPR010926; IPR027417; Unconventional myosin-Ib (MYH-1c) (Myosin I alpha) (MMI-alpha) (MMIa) MYO1B Homo sapiens (Human) TR19517_c0_g1_i1 O43583 DENR_HUMAN 5.00E-40 GO:0003743 Q9NX47; Q8WX92; P0CG48 translation initiation factor activity IPR005873; IPR001950; Density-regulated protein (DRP) (Protein DRP1) (Smooth muscle cell-associated protein 3) (SMAP-3) DENR DRP1 H14 Homo sapiens (Human) TR19519_c4_g1_i1 O88480 CABIN_RAT 4.00E-43 GO:0016568; GO:0005737; GO:0060548; GO:0005634; GO:0019904; GO:0030346; GO:0004864 chromatin modification; cytoplasm; negative regulation of cell death; nucleus; protein domain specific binding; protein phosphatase 2B binding; protein phosphatase inhibitor activity IPR015134; IPR013026; IPR011990; IPR019734; Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) Cabin1 Rattus norvegicus (Rat) TR19519_c5_g1_i1 Q9Y6J0 CABIN_HUMAN 4.00E-41 GO:0016235; GO:0007166; GO:0016568; GO:0005737; GO:0005634; GO:0004864 aggresome; cell surface receptor signaling pathway; chromatin modification; cytoplasm; nucleus; protein phosphatase inhibitor activity IPR015134; IPR013026; IPR011990; IPR019734; Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) CABIN1 KIAA0330 Homo sapiens (Human) TR1952_c0_g1_i1 Q8VCR2 DHB13_MOUSE 4.00E-08 GO:0005576; GO:0016491 extracellular region; oxidoreductase activity IPR002198; IPR002347; IPR016040; 17-beta-hydroxysteroid dehydrogenase 13 (17-beta-HSD 13) (EC 1.1.-.-) (Alcohol dehydrogenase PAN1B-like) (Short-chain dehydrogenase/reductase 9) Hsd17b13 Scdr9 Mus musculus (Mouse) TR19522_c0_g1_i1 O95498 VNN2_HUMAN 2.00E-32 GO:0031225; GO:0006928; GO:0017159; GO:0015939; GO:0005886 anchored to membrane; cellular component movement; pantetheine hydrolase activity; pantothenate metabolic process; plasma membrane IPR012101; IPR003010; Vascular non-inflammatory molecule 2 (Vanin-2) (EC 3.5.1.92) (Glycosylphosphatidyl inositol-anchored protein GPI-80) (Protein FOAP-4) VNN2 Homo sapiens (Human) TR19524_c0_g1_i3 Q9VQG2 APH1_DROME 1.00E-15 GO:0007219; GO:0004175; GO:0005887; GO:0043085; GO:0016485 Notch signaling pathway; endopeptidase activity; integral to plasma membrane; positive regulation of catalytic activity; protein processing IPR009294; Gamma-secretase subunit Aph-1 (Presenilin-stabilization factor) aph-1 PSF CG2855 Drosophila melanogaster (Fruit fly) TR19539_c0_g1_i1 B0BN95 HARB1_RAT 1.00E-17 GO:0005813; GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 centrosome; cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) Harbi1 Rattus norvegicus (Rat) TR19541_c4_g1_i1 Q8BMI0 FBX38_MOUSE 7.00E-50 GO:0005737; GO:0005634 cytoplasm; nucleus IPR001810; F-box only protein 38 (Modulator of KLF7 activity) (MoKA) Fbxo38 Mus musculus (Mouse) TR19542_c0_g1_i1 Q8WN22 PRKDC_CANFA 2.00E-79 GO:0005524; GO:0003677; GO:0006310; GO:0004677; GO:0006303; GO:0070419; GO:0005730 ATP binding; DNA binding; DNA recombination; DNA-dependent protein kinase activity; double-strand break repair via nonhomologous end joining; nonhomologous end joining complex; nucleolus IPR016024; IPR003152; IPR011009; IPR012582; IPR000403; IPR018936; IPR003151; IPR014009; DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) PRKDC Canis familiaris (Dog) (Canis lupus familiaris) TR19543_c0_g1_i1 P22448 RARB_CHICK 2.00E-127 GO:0071729; GO:0035108; GO:0005634; GO:0032526; GO:0003708; GO:0043565; GO:0003707; GO:0008270 beak morphogenesis; limb morphogenesis; nucleus; response to retinoic acid; retinoic acid receptor activity; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding IPR008946; IPR000536; IPR003078; IPR001723; IPR001628; IPR013088; Retinoic acid receptor beta (RAR-beta) (Nuclear receptor subfamily 1 group B member 2) RARB NR1B2 Gallus gallus (Chicken) TR19543_c0_g1_i2 Q08893 E75_MANSE 3.00E-44 GO:0005634; GO:0043565; GO:0003707; GO:0004887; GO:0008270 nucleus; sequence-specific DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; zinc ion binding IPR008946; IPR000536; IPR001723; IPR001728; IPR001628; IPR013088; Ecdysone-inducible protein E75 (Nuclear receptor subfamily 1 group D member 3) E75 NR1D3 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) TR19543_c0_g1_i3 P22448 RARB_CHICK 1.00E-127 GO:0071729; GO:0035108; GO:0005634; GO:0032526; GO:0003708; GO:0043565; GO:0003707; GO:0008270 beak morphogenesis; limb morphogenesis; nucleus; response to retinoic acid; retinoic acid receptor activity; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding IPR008946; IPR000536; IPR003078; IPR001723; IPR001628; IPR013088; Retinoic acid receptor beta (RAR-beta) (Nuclear receptor subfamily 1 group B member 2) RARB NR1B2 Gallus gallus (Chicken) TR19543_c0_g1_i4 P10826 RARB_HUMAN 1.00E-126 GO:0003677; GO:0005737; GO:0048566; GO:0048048; GO:0035116; GO:0003417; GO:0035264; GO:0061037; GO:0008285; GO:0032331; GO:0000122; GO:0022008; GO:0005654; GO:0043065; GO:0045944; GO:0003708; GO:0043565; GO:0003707; GO:0021756; GO:0006367; GO:0001657; GO:0055012; GO:0008270 P03255 DNA binding; cytoplasm; embryonic digestive tract development; embryonic eye morphogenesis; embryonic hindlimb morphogenesis; growth plate cartilage development; multicellular organism growth; negative regulation of cartilage development; negative regulation of cell proliferation; negative regulation of chondrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; neurogenesis; nucleoplasm; positive regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; retinoic acid receptor activity; sequence-specific DNA binding; steroid hormone receptor activity; striatum development; transcription initiation from RNA polymerase II promoter; ureteric bud development; ventricular cardiac muscle cell differentiation; zinc ion binding IPR008946; IPR000536; IPR003078; IPR001723; IPR001628; IPR013088; Retinoic acid receptor beta (RAR-beta) (HBV-activated protein) (Nuclear receptor subfamily 1 group B member 2) (RAR-epsilon) RARB HAP NR1B2 Homo sapiens (Human) TR19547_c0_g2_i1 Q6IFT4 RHG20_MOUSE 4.00E-14 GO:0005096; GO:0005622; GO:0005543; GO:0043547; GO:0007165 GTPase activator activity; intracellular; phospholipid binding; positive regulation of GTPase activity; signal transduction IPR011993; IPR001849; IPR000159; IPR008936; IPR000198; Rho GTPase-activating protein 20 (RA and RhoGAP domain-containing protein) (RARhoGAP) (Rho-type GTPase-activating protein 20) Arhgap20 Kiaa1391 Mus musculus (Mouse) TR19548_c0_g1_i1 Q6R520 CALM_OREMO 4.00E-42 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) calm Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica) TR19563_c0_g1_i1 Q4V9Y5 CRLD2_XENTR 9.00E-13 GO:0005576 extracellular region IPR001283; IPR018244; IPR014044; IPR004043; Cysteine-rich secretory protein LCCL domain-containing 2 crispld2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR19566_c2_g1_i1 Q6R5N8 TLR13_MOUSE 6.00E-11 GO:0002755; GO:0005768; GO:0010008; GO:0006954; GO:0045087; GO:0016021; GO:0042803; GO:0019843; GO:0043408; GO:0002237; GO:0009615; GO:0034178; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; endosome; endosome membrane; inflammatory response; innate immune response; integral to membrane; protein homodimerization activity; rRNA binding; regulation of MAPK cascade; response to molecule of bacterial origin; response to virus; toll-like receptor 13 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR003591; IPR000157; IPR027196; Toll-like receptor 13 Tlr13 Mus musculus (Mouse) TR19572_c0_g1_i1 P19039 EF1A_APIME 0 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; translation elongation factor activity IPR000795; IPR027417; IPR009000; IPR009001; IPR004539; IPR004161; IPR004160; Elongation factor 1-alpha (EF-1-alpha) Apis mellifera (Honeybee) TR19575_c0_g2_i1 P26262 KLKB1_MOUSE 1.00E-47 GO:0007596; GO:0005576; GO:0042730; GO:0006954; GO:0006508; GO:0004252 blood coagulation; extracellular region; fibrinolysis; inflammatory response; proteolysis; serine-type endopeptidase activity IPR000177; IPR003014; IPR003609; IPR001254; IPR018114; IPR001314; IPR009003; Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain] Klkb1 Klk3 Pk Mus musculus (Mouse) TR19575_c0_g3_i1 A8MTI9 PRS47_HUMAN 5.00E-13 GO:0005097; GO:0005576; GO:0032851; GO:0006508; GO:0004252 Rab GTPase activator activity; extracellular region; positive regulation of Rab GTPase activity; proteolysis; serine-type endopeptidase activity IPR001254; IPR001314; IPR000195; IPR009003; Putative serine protease 47 (EC 3.4.21.-) PRSS47 Homo sapiens (Human) TR19576_c1_g1_i1 Q00872 MYPC1_HUMAN 3.00E-08 GO:0007155; GO:0005829; GO:0030049; GO:0030016; GO:0032982; GO:0008307; GO:0031432 O75923; Q14324 cell adhesion; cytosol; muscle filament sliding; myofibril; myosin filament; structural constituent of muscle; titin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; "Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform)" MYBPC1 MYBPCS Homo sapiens (Human) TR19577_c0_g1_i1 C8VDQ4 GYP2_EMENI 9.00E-06 GO:0005097; GO:0005509; GO:0032851 Rab GTPase activator activity; calcium ion binding; positive regulation of Rab GTPase activity IPR011992; IPR000195; Putative GTPase-activating protein AN11010 AN11010 AN7784 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR19577_c1_g1_i1 Q6ZT07 TBCD9_HUMAN 4.00E-105 GO:0005097; GO:0005509; GO:0032851 Rab GTPase activator activity; calcium ion binding; positive regulation of Rab GTPase activity IPR011992; IPR002048; IPR004182; IPR000195; TBC1 domain family member 9 (TBC1 domain family member 9A) TBC1D9 KIAA0882 TBC1D9A Homo sapiens (Human) TR19582_c2_g1_i1 A2AVA0 SVEP1_MOUSE 3.00E-11 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)" Svep1 Mus musculus (Mouse) TR1959_c0_g1_i1 O95551 TYDP2_HUMAN 1.00E-08 GO:0070260; GO:0016605; GO:0007166; GO:0005737; GO:0006302; GO:0000287; GO:0030145; GO:0004518; GO:0090305; GO:0005730; GO:0003697; GO:0003714; GO:0036317 5'-tyrosyl-DNA phosphodiesterase activity; PML body; cell surface receptor signaling pathway; cytoplasm; double-strand break repair; magnesium ion binding; manganese ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleolus; single-stranded DNA binding; transcription corepressor activity; tyrosyl-RNA phosphodiesterase activity IPR005135; IPR009060; Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase) TDP2 EAP2 TTRAP AD-022 Homo sapiens (Human) TR19592_c1_g2_i1 Q8IYM9 TRI22_HUMAN 7.00E-06 GO:0015030; GO:0005794; GO:0051607; GO:0006955; GO:0016874; GO:0019048; GO:0016607; GO:0005634; GO:0070206; GO:0016567; GO:0009615; GO:0003700; GO:0003714; GO:0006351; GO:0008270 "Cajal body; Golgi apparatus; defense response to virus; immune response; ligase activity; modulation by virus of host morphology or physiology; nuclear speck; nucleus; protein trimerization; protein ubiquitination; response to virus; sequence-specific DNA binding transcription factor activity; transcription corepressor activity; transcription, DNA-dependent; zinc ion binding" IPR001870; IPR003879; IPR008985; IPR003877; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM22 (EC 6.3.2.-) (50 kDa-stimulated trans-acting factor) (RING finger protein 94) (Staf-50) (Tripartite motif-containing protein 22) TRIM22 RNF94 STAF50 Homo sapiens (Human) TR19592_c2_g1_i1 Q61010 DTX1_MOUSE 2.00E-23 GO:0007219; GO:0005829; GO:0010001; GO:0016874; GO:0045581; GO:0045665; GO:0005634; GO:0016567; GO:0008593; GO:0008270 Notch signaling pathway; cytosol; glial cell differentiation; ligase activity; negative regulation of T cell differentiation; negative regulation of neuron differentiation; nucleus; protein ubiquitination; regulation of Notch signaling pathway; zinc ion binding IPR004170; IPR018123; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DTX1 (EC 6.3.2.-) (FXI-T1) (Protein deltex-1) (Deltex1) (mDTX1) Dtx1 Mus musculus (Mouse) TR19592_c2_g1_i2 Q8TDB6 DTX3L_HUMAN 2.00E-37 GO:0005737; GO:0006302; GO:0042393; GO:0010390; GO:0005634; GO:0004842; GO:0008270 cytoplasm; double-strand break repair; histone binding; histone monoubiquitination; nucleus; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) TR19594_c0_g2_i1 Q95116 TSP2_BOVIN 3.00E-13 GO:0005509; GO:0007155; GO:0005576; GO:0008201 calcium ion binding; cell adhesion; extracellular region; heparin binding IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR024731; IPR001791; IPR000884; IPR015455; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-2 (Corticotropin-induced secreted protein) (CISP) THBS2 TSP-2 TSP2 Bos taurus (Bovine) TR19596_c1_g1_i1 Q05707 COEA1_HUMAN 3.00E-11 GO:0016337; GO:0005518; GO:0030574; GO:0030199; GO:0005596; GO:0005788; GO:0022617; GO:0005201; GO:0005615; GO:0048873; GO:0005614; GO:0030674; GO:0061050; GO:0003229 "cell-cell adhesion; collagen binding; collagen catabolic process; collagen fibril organization; collagen type XIV; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular matrix structural constituent; extracellular space; homeostasis of number of cells within a tissue; interstitial matrix; protein binding, bridging; regulation of cell growth involved in cardiac muscle cell development; ventricular cardiac muscle tissue development" IPR008160; IPR008985; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XIV) chain (Undulin) COL14A1 UND Homo sapiens (Human) TR19596_c1_g2_i1 Q9P218 COKA1_HUMAN 1.00E-06 GO:0005581; GO:0005788; GO:0030198; GO:0005576; GO:0005615 collagen; endoplasmic reticulum lumen; extracellular matrix organization; extracellular region; extracellular space IPR008160; IPR008985; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XX) chain COL20A1 KIAA1510 Homo sapiens (Human) TR19600_c0_g1_i1 Q1RLY6 KMO_DANRE 1.00E-67 GO:0009435; GO:0019674; GO:0016021; GO:0004502; GO:0005741; GO:0019805; GO:0006569 NAD biosynthetic process; NAD metabolic process; integral to membrane; kynurenine 3-monooxygenase activity; mitochondrial outer membrane; quinolinate biosynthetic process; tryptophan catabolic process IPR027545; IPR002938; IPR003042; Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3. Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase) kmo zgc:136684 Danio rerio (Zebrafish) (Brachydanio rerio) TR19602_c0_g1_i1 Q92503 S14L1_HUMAN 1.00E-76 GO:0005794; GO:0016021; GO:0016020; GO:0006810 Golgi apparatus; integral to membrane; membrane; transport IPR001251; IPR011074; IPR009038; IPR006797; SEC14-like protein 1 SEC14L1 SEC14L Homo sapiens (Human) TR19605_c0_g1_i1 O61463 RLA2_CRYST 3.00E-19 GO:0005840; GO:0003735; GO:0006414 ribosome; structural constituent of ribosome; translational elongation IPR001813; IPR027534; 60S acidic ribosomal protein P2 Cryptochiton stelleri (Giant gumboot chiton) TR1961_c0_g1_i1 Q7SZ78 THOC7_XENLA 2.00E-62 GO:0003723; GO:0008380; GO:0000445; GO:0005737; GO:0006397; GO:0051028 RNA binding; RNA splicing; THO complex part of transcription export complex; cytoplasm; mRNA processing; mRNA transport IPR008501; THO complex subunit 7 homolog thoc7 Xenopus laevis (African clawed frog) TR19611_c0_g1_i1 Q96MM6 HS12B_HUMAN 6.00E-18 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR19611_c1_g1_i1 B8I305 DNAK_CLOCE 3.00E-09 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK Ccel_1798 Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) TR19614_c2_g1_i1 Q6NS45 CCD66_MOUSE 2.00E-12 GO:0060060; GO:0046548 post-embryonic retina morphogenesis in camera-type eye; retinal rod cell development Coiled-coil domain-containing protein 66 Ccdc66 Mus musculus (Mouse) TR19619_c0_g1_i1 Q05975 RAB2_LYMST 5.00E-24 GO:0005525; GO:0000139; GO:0005789; GO:0033116; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi membrane; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-2 RAB2 Lymnaea stagnalis (Great pond snail) TR19625_c0_g1_i1 P42519 STAR_DROME 4.00E-11 GO:0005794; GO:0000139; GO:0048149; GO:0046845; GO:0046667; GO:0035225; GO:0005789; GO:0038004; GO:0007173; GO:0061331; GO:0007476; GO:0016021; GO:0007498; GO:0016318; GO:0048477; GO:0097038; GO:0007422; GO:0042461; GO:0005886; GO:0000042; GO:0048865; GO:0007421; GO:0007601 "Golgi apparatus; Golgi membrane; behavioral response to ethanol; branched duct epithelial cell fate determination, open tracheal system; compound eye retinal cell programmed cell death; determination of genital disc primordium; endoplasmic reticulum membrane; epidermal growth factor receptor ligand maturation; epidermal growth factor receptor signaling pathway; epithelial cell proliferation involved in Malpighian tubule morphogenesis; imaginal disc-derived wing morphogenesis; integral to membrane; mesoderm development; ommatidial rotation; oogenesis; perinuclear endoplasmic reticulum; peripheral nervous system development; photoreceptor cell development; plasma membrane; protein targeting to Golgi; stem cell fate commitment; stomatogastric nervous system development; visual perception" IPR006342; Protein Star S CG4385 Drosophila melanogaster (Fruit fly) TR19628_c0_g1_i1 P33527 MRP1_HUMAN 8.00E-98 GO:0005524; GO:0042626; GO:0005794; GO:0019369; GO:0009235; GO:0005887; GO:0006691; GO:0005634; GO:0042493 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; Golgi apparatus; arachidonic acid metabolic process; cobalamin metabolic process; integral to plasma membrane; leukotriene metabolic process; nucleus; response to drug" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP MRP1 Homo sapiens (Human) TR19630_c1_g1_i1 Q9HCD6 TANC2_HUMAN 3.00E-07 GO:0001701 in utero embryonic development IPR002110; IPR020683; IPR027417; IPR013026; IPR011990; IPR019734; "Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2)" TANC2 KIAA1148 KIAA1636 Homo sapiens (Human) TR19632_c5_g1_i1 Q5T7B8 KIF24_HUMAN 4.00E-52 GO:0005524; GO:0005814; GO:0042384; GO:0005871; GO:0005874; GO:0007019; GO:0003777; GO:0007018 O43303; Q8IW35 ATP binding; centriole; cilium assembly; kinesin complex; microtubule; microtubule depolymerization; microtubule motor activity; microtubule-based movement IPR027640; IPR019821; IPR001752; IPR027417; IPR001660; IPR013761; IPR021129; Kinesin-like protein KIF24 KIF24 C9orf48 Homo sapiens (Human) TR19635_c1_g1_i1 Q5RG82 NS1BA_DANRE 4.00E-18 GO:0005737; GO:0005856; GO:0005634 cytoplasm; cytoskeleton; nucleus IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Influenza virus NS1A-binding protein homolog A (NS1-BP homolog A) (NS1-binding protein homolog A) ivns1abpa si:dkeyp-11g8.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR19635_c2_g1_i1 Q70JS2 KELC_ANOST 6.00E-35 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR006652; Ring canal kelch homolog (Kelch-like protein 1) [Cleaved into: Kelch short protein] kel Anopheles stephensi (Indo-Pakistan malaria mosquito) TR19636_c0_g1_i1 Q99572 P2RX7_HUMAN 3.00E-15 GO:0005524; GO:0043132; GO:0043029; GO:0042098; GO:0000187; GO:0097190; GO:0032059; GO:0032060; GO:0000902; GO:0006884; GO:0005911; GO:0031668; GO:0046513; GO:0032963; GO:0005507; GO:0019835; GO:0005737; GO:0050830; GO:0009897; GO:0004931; GO:0048873; GO:0006954; GO:0045087; GO:0005639; GO:0005887; GO:0001530; GO:0000287; GO:0006900; GO:0051899; GO:0006509; GO:0045121; GO:0007005; GO:0044254; GO:0043409; GO:0045779; GO:0031594; GO:0043025; GO:0035872; GO:0001845; GO:0006649; GO:0045332; GO:0007009; GO:0046931; GO:0001916; GO:0043065; GO:0030501; GO:0010524; GO:0045919; GO:0051495; GO:0014054; GO:0014049; GO:0050717; GO:0050718; GO:0032755; GO:0051901; GO:0032308; GO:0043234; GO:0042803; GO:0051259; GO:0006468; GO:0016485; GO:0001614; GO:0072593; GO:0005102; GO:0019228; GO:0051709; GO:0002028; GO:0051209; GO:0033198; GO:0051592; GO:0042493; GO:0051602; GO:0034405; GO:0032496; GO:0009612; GO:0010043; GO:0019233; GO:0048705; GO:0016079; GO:0043195; GO:0008270 P00519; P62993; P16333 "ATP binding; NAD transport; T cell homeostasis; T cell proliferation; activation of MAPK activity; apoptotic signaling pathway; bleb; bleb assembly; cell morphogenesis; cell volume homeostasis; cell-cell junction; cellular response to extracellular stimulus; ceramide biosynthetic process; collagen metabolic process; copper ion binding; cytolysis; cytoplasm; defense response to Gram-positive bacterium; external side of plasma membrane; extracellular ATP-gated cation channel activity; homeostasis of number of cells within a tissue; inflammatory response; innate immune response; integral to nuclear inner membrane; integral to plasma membrane; lipopolysaccharide binding; magnesium ion binding; membrane budding; membrane depolarization; membrane protein ectodomain proteolysis; membrane raft; mitochondrion organization; multicellular organismal protein catabolic process; negative regulation of MAPK cascade; negative regulation of bone resorption; neuromuscular junction; neuronal cell body; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; phagolysosome assembly; phospholipid transfer to membrane; phospholipid translocation; plasma membrane organization; pore complex assembly; positive regulation of T cell mediated cytotoxicity; positive regulation of apoptotic process; positive regulation of bone mineralization; positive regulation of calcium ion transport into cytosol; positive regulation of cytolysis; positive regulation of cytoskeleton organization; positive regulation of gamma-aminobutyric acid secretion; positive regulation of glutamate secretion; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 production; positive regulation of mitochondrial depolarization; positive regulation of prostaglandin secretion; protein complex; protein homodimerization activity; protein oligomerization; protein phosphorylation; protein processing; purinergic nucleotide receptor activity; reactive oxygen species metabolic process; receptor binding; regulation of action potential in neuron; regulation of killing of cells of other organism; regulation of sodium ion transport; release of sequestered calcium ion into cytosol; response to ATP; response to calcium ion; response to drug; response to electrical stimulus; response to fluid shear stress; response to lipopolysaccharide; response to mechanical stimulus; response to zinc ion; sensory perception of pain; skeletal system morphogenesis; synaptic vesicle exocytosis; terminal bouton; zinc ion binding" IPR003050; IPR027309; IPR001429; P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2RX7 Homo sapiens (Human) TR19640_c1_g1_i1 Q96PQ7 KLHL5_HUMAN 3.00E-11 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR006652; Kelch-like protein 5 KLHL5 Homo sapiens (Human) TR19648_c0_g1_i1 P86854 PLCL_MYTGA 3.00E-07 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR19653_c0_g1_i1 Q8QG64 RBX1_SALSA 8.00E-30 GO:0031463; GO:0031464; GO:0031465; GO:0019788; GO:0019005; GO:0031146; GO:0005737; GO:0005634; GO:0006513; GO:0045116; GO:0006950; GO:0008270 Cul3-RING ubiquitin ligase complex; Cul4A-RING ubiquitin ligase complex; Cul4B-RING ubiquitin ligase complex; NEDD8 ligase activity; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cytoplasm; nucleus; protein monoubiquitination; protein neddylation; response to stress; zinc ion binding IPR001841; IPR013083; IPR024766; Protein modification; protein ubiquitination. RING-box protein 1 (Rbx1) (Hyperosmotic protein 21) (sHOP21) rbx1 hop21 Salmo salar (Atlantic salmon) TR19653_c1_g1_i1 Q08273 RBX1_YEAST 2.00E-17 GO:0031463; GO:0035361; GO:0000082; GO:0019005; GO:0031146; GO:0005737; GO:0005634; GO:0030674; GO:0042787; GO:0008270 P07834; Q12018; P38352; P14680; P53169; P40560 "Cul3-RING ubiquitin ligase complex; Cul8-RING ubiquitin ligase complex; G1/S transition of mitotic cell cycle; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cytoplasm; nucleus; protein binding, bridging; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; zinc ion binding" IPR001841; IPR013083; IPR024766; Protein modification; protein ubiquitination. RING-box protein HRT1 (RING-box protein 1) (E3 ubiquitin-protein ligase complex SCF subunit HRT1) (High level expression reduces Ty3 transposition protein 1) HRT1 RBX1 YOL133W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR19655_c1_g1_i1 O35245 PKD2_MOUSE 4.00E-12 GO:0007259; GO:0035904; GO:0045180; GO:0009925; GO:0001658; GO:0005262; GO:0005509; GO:0048763; GO:0007050; GO:0071498; GO:0071464; GO:0071470; GO:0042994; GO:0050982; GO:0003127; GO:0071910; GO:0001892; GO:0005783; GO:0031941; GO:0007507; GO:0001947; GO:0071458; GO:0071556; GO:0005887; GO:0001822; GO:0030027; GO:0001889; GO:0072177; GO:0072284; GO:0072218; GO:0072214; GO:0072219; GO:0072235; GO:0072075; GO:0035502; GO:0072208; GO:0005932; GO:0072686; GO:0031512; GO:2000134; GO:0060315; GO:0021915; GO:0031513; GO:0060674; GO:0005886; GO:0002133; GO:0071158; GO:0031659; GO:0010628; GO:0031587; GO:0045429; GO:0045944; GO:0005267; GO:0030814; GO:0090279; GO:0042127; GO:0051209; GO:0061441; GO:0061333; GO:0021510; GO:0005245; GO:0005248 "JAK-STAT cascade; aorta development; basal cortex; basal plasma membrane; branching involved in ureteric bud morphogenesis; calcium channel activity; calcium ion binding; calcium-induced calcium release activity; cell cycle arrest; cellular response to fluid shear stress; cellular response to hydrostatic pressure; cellular response to osmotic stress; cytoplasmic sequestering of transcription factor; detection of mechanical stimulus; detection of nodal flow; determination of liver left/right asymmetry; embryonic placenta development; endoplasmic reticulum; filamentous actin; heart development; heart looping; integral to cytosolic side of endoplasmic reticulum membrane; integral to lumenal side of endoplasmic reticulum membrane; integral to plasma membrane; kidney development; lamellipodium; liver development; mesonephric duct development; metanephric S-shaped body morphogenesis; metanephric ascending thin limb development; metanephric cortex development; metanephric cortical collecting duct development; metanephric distal tubule development; metanephric mesenchyme development; metanephric part of ureteric bud development; metanephric smooth muscle tissue development; microtubule basal body; mitotic spindle; motile primary cilium; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of ryanodine-sensitive calcium-release channel activity; neural tube development; nonmotile primary cilium; placenta blood vessel development; plasma membrane; polycystin complex; positive regulation of cell cycle arrest; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; positive regulation of nitric oxide biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; potassium channel activity; regulation of cAMP metabolic process; regulation of calcium ion import; regulation of cell proliferation; release of sequestered calcium ion into cytosol; renal artery morphogenesis; renal tubule morphogenesis; spinal cord development; voltage-gated calcium channel activity; voltage-gated sodium channel activity" IPR027359; IPR011992; IPR002048; IPR013122; IPR003915; Polycystin-2 (Polycystic kidney disease 2 protein homolog) Pkd2 Mus musculus (Mouse) TR19655_c1_g1_i3 Q9P0L9 PK2L1_HUMAN 1.00E-08 GO:0005262; GO:0005509; GO:0015269; GO:0009986; GO:0071468; GO:0001581; GO:0050982; GO:0005783; GO:0042802; GO:0016021; GO:0005886; GO:0005272; GO:0033040 calcium channel activity; calcium ion binding; calcium-activated potassium channel activity; cell surface; cellular response to acidity; detection of chemical stimulus involved in sensory perception of sour taste; detection of mechanical stimulus; endoplasmic reticulum; identical protein binding; integral to membrane; plasma membrane; sodium channel activity; sour taste receptor activity IPR011992; IPR013122; IPR003915; Polycystic kidney disease 2-like 1 protein (Polycystin-2 homolog) (Polycystin-2L1) (Polycystin-L) (Polycystin-L1) PKD2L1 PKD2L PKDL Homo sapiens (Human) TR19655_c2_g1_i1 Q7TN88 PK1L2_MOUSE 1.00E-16 GO:0005262; GO:0005509; GO:0030246; GO:0050982; GO:0016021; GO:0016020; GO:0007218 calcium channel activity; calcium ion binding; carbohydrate binding; detection of mechanical stimulus; integral to membrane; membrane; neuropeptide signaling pathway IPR001304; IPR016186; IPR016187; IPR000203; IPR000922; IPR008976; IPR022409; IPR002859; IPR013122; IPR003915; IPR000601; IPR001024; IPR014010; Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) Pkd1l2 Mus musculus (Mouse) TR19661_c1_g1_i1 Q9C098 DCLK3_HUMAN 2.00E-15 GO:0005524; GO:0005737; GO:0005634; GO:0004674 ATP binding; cytoplasm; nucleus; protein serine/threonine kinase activity IPR020636; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase DCLK3 (EC 2.7.11.1) (Doublecortin domain-containing protein 3C) (Doublecortin-like and CAM kinase-like 3) (Doublecortin-like kinase 3) DCLK3 DCAMKL3 DCDC3C KIAA1765 Homo sapiens (Human) TR19662_c0_g1_i1 A8WHP9 LRRC3_DANRE 4.00E-10 GO:0016021 integral to membrane IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing protein 3 lrrc3 sc:d0333 si:dkey-253a1.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR19662_c0_g2_i1 A8WHP9 LRRC3_DANRE 4.00E-07 GO:0016021 integral to membrane IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing protein 3 lrrc3 sc:d0333 si:dkey-253a1.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR19666_c0_g1_i1 Q9JKZ2 SC5A3_MOUSE 7.00E-42 GO:0006020; GO:0016021; GO:0015798; GO:0007422; GO:0043576; GO:0006814; GO:0015293 inositol metabolic process; integral to membrane; myo-inositol transport; peripheral nervous system development; regulation of respiratory gaseous exchange; sodium ion transport; symporter activity IPR001734; IPR018212; IPR019900; Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3) Slc5a3 Mus musculus (Mouse) TR19670_c0_g1_i1 Q08431 MFGM_HUMAN 5.00E-06 GO:0001525; GO:0007155; GO:0009897; GO:0005615; GO:0070062; GO:0019897; GO:0019048; GO:0006911; GO:0006910; GO:0008429; GO:0001786; GO:2000427; GO:0007338 "angiogenesis; cell adhesion; external side of plasma membrane; extracellular space; extracellular vesicular exosome; extrinsic to plasma membrane; modulation by virus of host morphology or physiology; phagocytosis, engulfment; phagocytosis, recognition; phosphatidylethanolamine binding; phosphatidylserine binding; positive regulation of apoptotic cell clearance; single fertilization" IPR000421; IPR000742; IPR013032; IPR008979; Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin] MFGE8 Homo sapiens (Human) TR19671_c1_g1_i1 P58544 BTBD1_MOUSE 6.00E-11 GO:0000932; GO:0043234; GO:0016567 cytoplasmic mRNA processing body; protein complex; protein ubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; Protein modification; protein ubiquitination. BTB/POZ domain-containing protein 1 (Glucose signal-repressing protein) Btbd1 Gsrp Mus musculus (Mouse) TR19675_c1_g1_i1 Q8SPU8 DHRS4_BOVIN 9.00E-08 GO:0004090; GO:0005739; GO:0005777 carbonyl reductase (NADPH) activity; mitochondrion; peroxisome IPR002198; IPR002347; IPR016040; IPR020904; Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) DHRS4 NDRD Bos taurus (Bovine) TR19679_c2_g1_i1 P38137 FAT2_YEAST 1.00E-12 GO:0016208; GO:0016874; GO:0003729; GO:0005782; GO:0005778 Itself AMP binding; ligase activity; mRNA binding; peroxisomal matrix; peroxisomal membrane IPR025110; IPR020845; IPR000873; Peroxisomal-coenzyme A synthetase (EC 6.-.-.-) PCS60 FAT2 YBR222C YBR1512 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR19679_c3_g1_i1 Q6GLK6 ACSF3_XENLA 3.00E-36 GO:0005524; GO:0006631; GO:0016874; GO:0005739 ATP binding; fatty acid metabolic process; ligase activity; mitochondrion IPR025110; IPR020845; IPR000873; "Acyl-CoA synthetase family member 3, mitochondrial (EC 6.2.1.-)" acsf3 Xenopus laevis (African clawed frog) TR19684_c1_g1_i1 P14381 YTX2_XENLA 2.00E-08 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR19690_c0_g1_i1 P0C605 KGP1_MOUSE 1.00E-07 GO:0005524; GO:0005794; GO:0030553; GO:0004692; GO:0005246; GO:0016358; GO:0030900; GO:0090331; GO:0001764; GO:0005886; GO:0043087; GO:0007165 O35607 ATP binding; Golgi apparatus; cGMP binding; cGMP-dependent protein kinase activity; calcium channel regulator activity; dendrite development; forebrain development; negative regulation of platelet aggregation; neuron migration; plasma membrane; regulation of GTPase activity; signal transduction IPR000961; IPR016232; IPR002374; IPR018490; IPR018488; IPR000595; IPR011009; IPR000719; IPR017441; IPR014710; IPR002290; IPR008271; cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) Prkg1 Prkg1b Prkgr1a Prkgr1b Mus musculus (Mouse) TR19696_c1_g1_i1 B2RXF0 T229A_HUMAN 8.00E-34 GO:0042025; GO:0016021; GO:0003700 host cell nucleus; integral to membrane; sequence-specific DNA binding transcription factor activity IPR001831 Transmembrane protein 229A TMEM229A Homo sapiens (Human) TR19699_c0_g2_i1 A4FV84 MRT4_BOVIN 3.00E-96 GO:0031965; GO:0005730; GO:0042254 nuclear membrane; nucleolus; ribosome biogenesis IPR001790; mRNA turnover protein 4 homolog MRTO4 Bos taurus (Bovine) TR19700_c0_g1_i1 P06144 H1_LYTPI 3.00E-22 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR005818; IPR005819; IPR011991; Late histone H1 Lytechinus pictus (Painted sea urchin) TR19702_c0_g1_i1 Q58WW2 DCAF6_HUMAN 2.00E-114 GO:0080008; GO:0030374; GO:0005634; GO:0045944; GO:0016567 Cul4-RING ubiquitin ligase complex; ligand-dependent nuclear receptor transcription coactivator activity; nucleus; positive regulation of transcription from RNA polymerase II promoter; protein ubiquitination IPR000048; IPR015943; IPR001680; IPR017986; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP) DCAF6 IQWD1 MSTP055 Homo sapiens (Human) TR19702_c0_g1_i2 Q8BUB4 WDFY2_MOUSE 5.00E-06 GO:0046872 metal ion binding IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; IPR000306; IPR017455; IPR013083; WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain-containing protein 2) Wdfy2 Mus musculus (Mouse) TR19709_c1_g1_i1 Q8MQW8 SPRI_DROME 2.00E-13 GO:0005096; GO:0007298; GO:0005938; GO:0030139; GO:0006897; GO:0005085; GO:0007275; GO:0043547; GO:0007165 GTPase activator activity; border follicle cell migration; cell cortex; endocytic vesicle; endocytosis; guanyl-nucleotide exchange factor activity; multicellular organismal development; positive regulation of GTPase activity; signal transduction IPR000159; IPR000980; IPR003123; IPR013995; Protein sprint (SH2 poly-proline-containing Ras-interactor protein) spri CG34414 Drosophila melanogaster (Fruit fly) TR19712_c0_g1_i1 Q9Y4F5 K0284_HUMAN 4.00E-11 GO:0005737; GO:0005874 cytoplasm; microtubule IPR000253; IPR008984; Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) CEP170B FAM68C KIAA0284 Homo sapiens (Human) TR19713_c0_g1_i1 Q6DCU6 SGMR1_XENLA 3.00E-89 GO:0000247; GO:0005789; GO:0006696; GO:0016021; GO:0006869; GO:0005637; GO:0005640; GO:0005886 C-8 sterol isomerase activity; endoplasmic reticulum membrane; ergosterol biosynthetic process; integral to membrane; lipid transport; nuclear inner membrane; nuclear outer membrane; plasma membrane IPR006716; Sigma non-opioid intracellular receptor 1 (Sigma 1-type opioid receptor) (Sigma1-receptor) (Sigma1R) sigmar1 oprs1 Xenopus laevis (African clawed frog) TR19723_c0_g2_i1 O75445 USH2A_HUMAN 2.00E-19 GO:0016324; GO:0005604; GO:0005518; GO:0005737; GO:0035315; GO:0060113; GO:0016021; GO:0048496; GO:0017022; GO:0045494; GO:0050896; GO:0050953; GO:0007605; GO:0002142; GO:0060171; GO:0007601 apical plasma membrane; basement membrane; collagen binding; cytoplasm; hair cell differentiation; inner ear receptor cell differentiation; integral to membrane; maintenance of organ identity; myosin binding; photoreceptor cell maintenance; response to stimulus; sensory perception of light stimulus; sensory perception of sound; stereocilia ankle link complex; stereocilium membrane; visual perception IPR008985; IPR013320; IPR002049; IPR003961; IPR013783; IPR006558; IPR001791; IPR008211; IPR026915; Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein) USH2A Homo sapiens (Human) TR19729_c5_g1_i1 P91645 CAC1A_DROME 1.00E-88 GO:0008344; GO:0016324; GO:0016323; GO:0005509; GO:0050908; GO:0042045; GO:0006887; GO:0008331; GO:0008332; GO:0045433; GO:0007275; GO:0007269; GO:0007602; GO:0045887; GO:0048786; GO:0002027; GO:0046928; GO:0007632; GO:0005891 "adult locomotory behavior; apical plasma membrane; basolateral plasma membrane; calcium ion binding; detection of light stimulus involved in visual perception; epithelial fluid transport; exocytosis; high voltage-gated calcium channel activity; low voltage-gated calcium channel activity; male courtship behavior, veined wing generated song production; multicellular organismal development; neurotransmitter secretion; phototransduction; positive regulation of synaptic growth at neuromuscular junction; presynaptic active zone; regulation of heart rate; regulation of neurotransmitter secretion; visual behavior; voltage-gated calcium channel complex" IPR027359; IPR002048; IPR005821; IPR014873; IPR002077; Voltage-dependent calcium channel type A subunit alpha-1 (Protein cacophony) (Protein nightblind A) (Protein no-on-transient B) (Dmca1A) cac nbA nonB CG43368 Drosophila melanogaster (Fruit fly) TR1973_c0_g1_i1 P33609 DPOLA_MOUSE 1.00E-25 GO:0008408; GO:0051539; GO:0003677; GO:0003896; GO:0006270; GO:0003887; GO:0005658; GO:0008283; GO:0000785; GO:0003682; GO:0005737; GO:0006303; GO:0006273; GO:0006272; GO:0046872; GO:0000084; GO:0005635; GO:0016363; GO:0005730; GO:0005654; GO:0001882; GO:0000166; GO:0019985 P33611; P20664 "3'-5' exonuclease activity; 4 iron, 4 sulfur cluster binding; DNA binding; DNA primase activity; DNA replication initiation; DNA-directed DNA polymerase activity; alpha DNA polymerase:primase complex; cell proliferation; chromatin; chromatin binding; cytoplasm; double-strand break repair via nonhomologous end joining; lagging strand elongation; leading strand elongation; metal ion binding; mitotic S phase; nuclear envelope; nuclear matrix; nucleolus; nucleoplasm; nucleoside binding; nucleotide binding; translesion synthesis" IPR006172; IPR017964; IPR006133; IPR006134; IPR004578; IPR024647; IPR023211; IPR012337; IPR015088; DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) Pola1 Pola Mus musculus (Mouse) TR19730_c2_g1_i1 Q9ESL4 MLTK_MOUSE 2.00E-12 GO:0005524; GO:0004709; GO:0000075; GO:0005737; GO:0007010; GO:0000287; GO:0005634; GO:0043065 ATP binding; MAP kinase kinase kinase activity; cell cycle checkpoint; cytoplasm; cytoskeleton organization; magnesium ion binding; nucleus; positive regulation of apoptotic process IPR011009; IPR000719; IPR001660; IPR013761; IPR021129; IPR001245; IPR008271; Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (Leucine zipper- and sterile alpha motif kinase ZAK) (MLK-like mitogen-activated protein triple kinase) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) Mltk Mus musculus (Mouse) TR19731_c0_g1_i1 A4IF63 TRIM2_BOVIN 2.00E-08 GO:0005737; GO:0043523; GO:0004842; GO:0008270 cytoplasm; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) TR19732_c0_g1_i1 P97739 ECE1_CAVPO 6.00E-45 GO:0016021; GO:0046872; GO:0004222; GO:0005886; GO:0006508 integral to membrane; metal ion binding; metalloendopeptidase activity; plasma membrane; proteolysis IPR024079; IPR000718; IPR018497; IPR008753; Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) ECE1 Cavia porcellus (Guinea pig) TR19738_c0_g1_i1 Q9PPU2 UNG_UREPA 2.00E-13 GO:0006284; GO:0005737; GO:0004844 base-excision repair; cytoplasm; uracil DNA N-glycosylase activity IPR018085; IPR002043; IPR005122; Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) ung UU548 Ureaplasma parvum serovar 3 (strain ATCC 700970) TR19738_c1_g1_i1 P97931 UNG_MOUSE 2.00E-39 GO:0006281; GO:0006284; GO:0005739; GO:0005634; GO:0016446; GO:0016447; GO:0004844 DNA repair; base-excision repair; mitochondrion; nucleus; somatic hypermutation of immunoglobulin genes; somatic recombination of immunoglobulin gene segments; uracil DNA N-glycosylase activity IPR018085; IPR002043; IPR005122; Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) Ung Ung1 Mus musculus (Mouse) TR19738_c2_g1_i1 P12887 UNG_YEAST 5.00E-20 GO:0006281; GO:0006284; GO:0005739; GO:0005634; GO:0004844 DNA repair; base-excision repair; mitochondrion; nucleus; uracil DNA N-glycosylase activity IPR018085; IPR002043; IPR005122; Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) UNG1 YML021C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR19740_c0_g1_i1 H2A0M0 NRP_PINMG 4.00E-10 GO:0005576 extracellular region IPR008985; Asparagine-rich protein (Prism uncharacterized shell protein 1) (PUSP1) Pinctada margaritifera (Black-lipped pearl oyster) TR19740_c0_g2_i1 P86860 PSM_MYTCA 4.00E-08 GO:0005576 extracellular region IPR008985; IPR013320; Shell matrix protein (Fragment) Mytilus californianus (California mussel) TR19749_c0_g1_i1 Q61361 PGCB_MOUSE 3.00E-16 GO:0030246; GO:0007155; GO:0021766; GO:0005540; GO:0005578 carbohydrate binding; cell adhesion; hippocampus development; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR007110; IPR013783; IPR003006; IPR013106; IPR003596; IPR000538; IPR000436; Brevican core protein Bcan Mus musculus (Mouse) TR19749_c0_g2_i1 P82596 PLC_HALLA 2.00E-15 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR19751_c0_g1_i1 P81178 ALDH2_MESAU 0 GO:0004029; GO:0006068; GO:0005759 aldehyde dehydrogenase (NAD) activity; ethanol catabolic process; mitochondrial matrix IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. "Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDH1)" ALDH2 Mesocricetus auratus (Golden hamster) TR19751_c0_g1_i2 Q802W2 A9A1B_DANRE 4.00E-83 GO:0004029; GO:0005737 aldehyde dehydrogenase (NAD) activity; cytoplasm IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Aldehyde dehydrogenase family 9 member A1-B (EC 1.2.1.3) aldh9a1b aldh9a1 si:ch211-284b7.5 Danio rerio (Zebrafish) (Brachydanio rerio) TR19754_c1_g1_i1 P09487 PPBT_BOVIN 2.00E-97 GO:0004035; GO:0031225; GO:0046872; GO:0005886; GO:0033280 alkaline phosphatase activity; anchored to membrane; metal ion binding; plasma membrane; response to vitamin D IPR017849; IPR001952; IPR018299; IPR017850; "Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)" ALPL Bos taurus (Bovine) TR19761_c1_g1_i1 Q7Z5M8 AB12B_HUMAN 3.00E-21 GO:0047372 acylglycerol lipase activity IPR026605; Abhydrolase domain-containing protein 12B (EC 3.-.-.-) ABHD12B C14orf29 Homo sapiens (Human) TR19761_c1_g2_i1 Q08C93 ABD12_DANRE 1.00E-35 GO:0047372; GO:0016021 acylglycerol lipase activity; integral to membrane IPR026605; Monoacylglycerol lipase ABHD12 (EC 3.1.1.23) (Abhydrolase domain-containing protein 12) abhd12 si:ch211-79l10.2 zgc:153367 Danio rerio (Zebrafish) (Brachydanio rerio) TR19765_c0_g1_i1 Q53FA7 QORX_HUMAN 9.00E-121 GO:0006739; GO:0070402; GO:0003960; GO:0008631; GO:0048038; GO:0008270 NADP metabolic process; NADPH binding; NADPH:quinone reductase activity; intrinsic apoptotic signaling pathway in response to oxidative stress; quinone binding; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; IPR014189; Quinone oxidoreductase PIG3 (EC 1.-.-.-) (Tumor protein p53-inducible protein 3) (p53-induced gene 3 protein) TP53I3 PIG3 Homo sapiens (Human) TR19765_c0_g1_i2 B0BNC9 QORL2_RAT 4.00E-25 GO:0005739; GO:0016491; GO:0008270 mitochondrion; oxidoreductase activity; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; Quinone oxidoreductase-like protein 2 (EC 1.-.-.-) Rattus norvegicus (Rat) TR19768_c0_g1_i1 Q91ZW7 C209E_MOUSE 5.00E-18 GO:0006897; GO:0016021; GO:0005537 endocytosis; integral to membrane; mannose binding IPR001304; IPR016186; IPR018378; IPR016187; CD209 antigen-like protein E (DC-SIGN-related protein 4) (DC-SIGNR4) (CD antigen CD209) Cd209e Mus musculus (Mouse) TR19768_c0_g2_i1 Q6QLQ4 CLC7A_MOUSE 2.00E-06 GO:0001872; GO:0001874; GO:0002752; GO:0016337; GO:0071226; GO:0001879; GO:0009897; GO:0006954; GO:0045087; GO:0016021; GO:0002366; GO:0046872; GO:0001846; GO:0006911; GO:0006910; GO:0050766; GO:0032760 "(1->3)-beta-D-glucan binding; (1->3)-beta-D-glucan receptor activity; cell surface pattern recognition receptor signaling pathway; cell-cell adhesion; cellular response to molecule of fungal origin; detection of yeast; external side of plasma membrane; inflammatory response; innate immune response; integral to membrane; leukocyte activation involved in immune response; metal ion binding; opsonin binding; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of phagocytosis; positive regulation of tumor necrosis factor production" IPR001304; IPR016186; IPR016187; C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1) Clec7a Bgr Clecsf12 Dectin1 Mus musculus (Mouse) TR19775_c0_g1_i1 Q9D3D9 ATPD_MOUSE 1.00E-42 GO:0006200; GO:0015986; GO:0005753; GO:0046933; GO:0045261; GO:0046961 "ATP catabolic process; ATP synthesis coupled proton transport; mitochondrial proton-transporting ATP synthase complex; proton-transporting ATP synthase activity, rotational mechanism; proton-transporting ATP synthase complex, catalytic core F(1); proton-transporting ATPase activity, rotational mechanism" IPR001469; IPR020546; IPR020547; "ATP synthase subunit delta, mitochondrial (F-ATPase delta subunit)" Atp5d Mus musculus (Mouse) TR19781_c0_g1_i1 Q8NCA9 ZN784_HUMAN 6.00E-20 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 784 ZNF784 Homo sapiens (Human) TR19781_c0_g2_i1 P39770 SALM_DROME 6.00E-08 GO:0003677; GO:0045466; GO:0045465; GO:0048098; GO:0046845; GO:0007427; GO:0008586; GO:0030539; GO:0008584; GO:0046872; GO:0048644; GO:0045892; GO:0035310; GO:0005634; GO:0007438; GO:0042659; GO:0007605; GO:0007525; GO:0035277; GO:0006351 "DNA binding; R7 cell differentiation; R8 cell differentiation; antennal joint development; branched duct epithelial cell fate determination, open tracheal system; epithelial cell migration, open tracheal system; imaginal disc-derived wing vein morphogenesis; male genitalia development; male gonad development; metal ion binding; muscle organ morphogenesis; negative regulation of transcription, DNA-dependent; notum cell fate specification; nucleus; oenocyte development; regulation of cell fate specification; sensory perception of sound; somatic muscle development; spiracle morphogenesis, open tracheal system; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Homeotic protein spalt-major salm sal CG6464 Drosophila melanogaster (Fruit fly) TR19781_c0_g3_i1 Q14590 ZN235_HUMAN 3.00E-52 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) TR19782_c2_g1_i1 Q9LJN4 BXL5_ARATH 2.00E-21 GO:0005975; GO:0005618; GO:0004553; GO:0005578 "carbohydrate metabolic process; cell wall; hydrolase activity, hydrolyzing O-glycosyl compounds; proteinaceous extracellular matrix" IPR026891; IPR026892; IPR002772; IPR001764; IPR017853; Probable beta-D-xylosidase 5 (AtBXL5) (EC 3.2.1.-) BXL5 At3g19620 MMB12.15 Arabidopsis thaliana (Mouse-ear cress) TR19789_c1_g1_i1 P47825 TAF4_DROME 2.00E-42 GO:0003677; GO:0051123; GO:0048813; GO:0007517; GO:0045944; GO:0003700; GO:0005669 P03255 DNA binding; RNA polymerase II transcriptional preinitiation complex assembly; dendrite morphogenesis; muscle organ development; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription factor TFIID complex IPR009072; IPR007900; IPR003894; Transcription initiation factor TFIID subunit 4 (110 kDa TBP-associated factor) (Transcription initiation factor TFIID 110 kDa subunit) (TAFII-110) (p110) Taf4 TAF110 CG5444 Drosophila melanogaster (Fruit fly) TR1979_c1_g1_i1 E6ZHJ8 FXL15_DICLA 1.00E-13 GO:0000086; GO:0019005; GO:0031146; GO:0030282; GO:0005737; GO:0009953; GO:0030513; GO:0016567 G2/M transition of mitotic cell cycle; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; bone mineralization; cytoplasm; dorsal/ventral pattern formation; positive regulation of BMP signaling pathway; protein ubiquitination IPR001810; Protein modification; protein ubiquitination. F-box/LRR-repeat protein 15 fbxl15 DLA_Ib03740 DLA_Ib03750 Dicentrarchus labrax (European seabass) (Morone labrax) TR19795_c0_g1_i1 O75460 ERN1_HUMAN 7.00E-41 GO:0005524; GO:0070055; GO:0006987; GO:0006915; GO:0007050; GO:0004521; GO:0030176; GO:0000287; GO:0005739; GO:0005637; GO:1900103; GO:0046777; GO:0004674; GO:0006355; GO:0006351 Itself; O08734; Q07812; Q07813; P20029; Q86TM6; Q9H2K8; Q12933 "ATP binding; HAC1-type intron splice site recognition and cleavage; activation of signaling protein activity involved in unfolded protein response; apoptotic process; cell cycle arrest; endoribonuclease activity; integral to endoplasmic reticulum membrane; magnesium ion binding; mitochondrion; nuclear inner membrane; positive regulation of endoplasmic reticulum unfolded protein response; protein autophosphorylation; protein serine/threonine kinase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR010513; IPR011009; IPR018391; IPR000719; IPR006567; IPR027295; IPR011047; IPR008271; Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] ERN1 IRE1 Homo sapiens (Human) TR19798_c0_g1_i2 P20782 ACHE_MOUSE 6.00E-11 GO:0004889; GO:0030054; GO:0016021; GO:0045211; GO:0042391 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane; regulation of membrane potential IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit epsilon Chrne Acre Mus musculus (Mouse) TR1980_c0_g1_i1 Q8K0U4 HS12A_MOUSE 2.00E-08 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR19805_c1_g1_i1 Q9WVT6 CAH14_MOUSE 2.00E-12 GO:0004089; GO:0016021; GO:0046872 carbonate dehydratase activity; integral to membrane; metal ion binding IPR018429; IPR001148; IPR023561; Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV) Ca14 Car14 Catm Mus musculus (Mouse) TR19807_c0_g1_i1 P42577 FRIS_LYMST 3.00E-98 GO:0006879; GO:0005737; GO:0008199; GO:0004322; GO:0006826 cellular iron ion homeostasis; cytoplasm; ferric iron binding; ferroxidase activity; iron ion transport IPR001519; IPR009040; IPR009078; IPR012347; IPR014034; IPR008331; Soma ferritin (EC 1.16.3.1) Lymnaea stagnalis (Great pond snail) TR19814_c3_g1_i1 Q811B3 ATS12_MOUSE 3.00E-06 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAM-TS 12) (ADAM-TS12) (ADAMTS-12) (EC 3.4.24.-) Adamts12 Mus musculus (Mouse) TR19815_c0_g1_i1 Q24524 SING_DROME 2.00E-141 GO:0015629; GO:0051015; GO:0048800; GO:0008407; GO:0035017; GO:0005737; GO:0016358; GO:0007163; GO:0046847; GO:0035099; GO:0035317; GO:0030034; GO:0043005; GO:0048812; GO:0043025; GO:0048477; GO:0042060 actin cytoskeleton; actin filament binding; antennal morphogenesis; chaeta morphogenesis; cuticle pattern formation; cytoplasm; dendrite development; establishment or maintenance of cell polarity; filopodium assembly; hemocyte migration; imaginal disc-derived wing hair organization; microvillar actin bundle assembly; neuron projection; neuron projection morphogenesis; neuronal cell body; oogenesis; wound healing IPR008999; IPR010431; IPR022768; IPR024703; Protein singed sn CG1536 Drosophila melanogaster (Fruit fly) TR19822_c2_g1_i1 H2A0M0 NRP_PINMG 6.00E-18 GO:0005576 extracellular region IPR008985; Asparagine-rich protein (Prism uncharacterized shell protein 1) (PUSP1) Pinctada margaritifera (Black-lipped pearl oyster) TR19824_c2_g1_i1 Q99N01 SO4A1_RAT 4.00E-18 GO:0016021; GO:0005886; GO:0042403; GO:0015349 integral to membrane; plasma membrane; thyroid hormone metabolic process; thyroid hormone transmembrane transporter activity IPR002350; IPR020846; IPR016196; IPR004156; Solute carrier organic anion transporter family member 4A1 (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) Slco4a1 Oatp4a1 Oatpe Slc21a12 Rattus norvegicus (Rat) TR19827_c0_g1_i1 P07919 QCR6_HUMAN 5.00E-10 GO:0009060; GO:0006122; GO:0005746; GO:0005750; GO:0006119; GO:0051291; GO:0022904; GO:0044281; GO:0008121 "aerobic respiration; mitochondrial electron transport, ubiquinol to cytochrome c; mitochondrial respiratory chain; mitochondrial respiratory chain complex III; oxidative phosphorylation; protein heterooligomerization; respiratory electron transport chain; small molecule metabolic process; ubiquinol-cytochrome-c reductase activity" IPR003422; IPR023184; "Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein)" UQCRH Homo sapiens (Human) TR19834_c0_g1_i1 Q9UPW6 SATB2_HUMAN 8.00E-13 GO:0051216; GO:0071310; GO:0003682; GO:0006338; GO:0005737; GO:0009880; GO:0048704; GO:0000118; GO:0000122; GO:0001764; GO:0016363; GO:0005634; GO:0002076; GO:0060021; GO:0045944; GO:0043565; GO:0003700; GO:0005667; GO:0006351 Q9H3D4-2 "cartilage development; cellular response to organic substance; chromatin binding; chromatin remodeling; cytoplasm; embryonic pattern specification; embryonic skeletal system morphogenesis; histone deacetylase complex; negative regulation of transcription from RNA polymerase II promoter; neuron migration; nuclear matrix; nucleus; osteoblast development; palate development; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent" IPR003350; IPR001356; IPR009057; IPR010982; DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) SATB2 KIAA1034 Homo sapiens (Human) TR19838_c0_g1_i1 Q98SN7 WNT2B_CHICK 4.00E-43 GO:0060219; GO:0060070; GO:0008283; GO:0061303; GO:0060900; GO:0035115; GO:0061072; GO:0002088; GO:0002011; GO:0045686; GO:0045665; GO:0045743; GO:0005578; GO:0060828; GO:0010842 camera-type eye photoreceptor cell differentiation; canonical Wnt receptor signaling pathway; cell proliferation; cornea development in camera-type eye; embryonic camera-type eye formation; embryonic forelimb morphogenesis; iris morphogenesis; lens development in camera-type eye; morphogenesis of an epithelial sheet; negative regulation of glial cell differentiation; negative regulation of neuron differentiation; positive regulation of fibroblast growth factor receptor signaling pathway; proteinaceous extracellular matrix; regulation of canonical Wnt receptor signaling pathway; retina layer formation IPR005817; IPR009140; IPR018161; Protein Wnt-2b WNT2B Gallus gallus (Chicken) TR19839_c0_g2_i1 Q8N5H7 SH2D3_HUMAN 6.00E-23 GO:0007254; GO:0005070; GO:0005737; GO:0005085; GO:0016020; GO:0007264 JNK cascade; SH3/SH2 adaptor activity; cytoplasm; guanyl-nucleotide exchange factor activity; membrane; small GTPase mediated signal transduction IPR023578; IPR001895; IPR000980; SH2 domain-containing protein 3C (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) SH2D3C NSP3 UNQ272/PRO309/PRO34088 Homo sapiens (Human) TR1984_c0_g2_i1 P91850 MIFH_BRUMA 8.00E-06 GO:0004167; GO:0005615; GO:0050178 dopachrome isomerase activity; extracellular space; phenylpyruvate tautomerase activity IPR001398; IPR019829; IPR014347; Macrophage migration inhibitory factor homolog (Bm-MIF-1) (BmMIF) (MIF) (EC 5.3.2.1) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) Bm1_28435 BMBAC01P19.1 Brugia malayi (Filarial nematode worm) TR19844_c0_g1_i4 P13821 SANT_PLAFW 3.00E-07 GO:0020003 symbiont-containing vacuole IPR008825; S-antigen protein Plasmodium falciparum (isolate Wellcome) TR19845_c2_g1_i1 P42325 NCAH_DROME 4.00E-32 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Neurocalcin homolog (DrosNCa) Nca CG7641 Drosophila melanogaster (Fruit fly) TR19850_c0_g1_i1 Q9EPN1 NBEA_MOUSE 3.00E-78 GO:0030054; GO:0005829; GO:0012505; GO:0006892; GO:0045211; GO:0051018; GO:0019901; GO:0006605; GO:0005802 cell junction; cytosol; endomembrane system; post-Golgi vesicle-mediated transport; postsynaptic membrane; protein kinase A binding; protein kinase binding; protein targeting; trans-Golgi network IPR016024; IPR000409; IPR008985; IPR013320; IPR010508; IPR023362; IPR015943; IPR001680; IPR017986; Neurobeachin (Lysosomal-trafficking regulator 2) Nbea Lyst2 Mus musculus (Mouse) TR19851_c1_g1_i1 Q9VW71 FAT2_DROME 3.00E-33 GO:0009925; GO:0005509; GO:0016339; GO:0050839; GO:0050829; GO:0042247; GO:0030950; GO:0005925; GO:0007440; GO:0007295; GO:0007442; GO:0007156; GO:0005887; GO:0045571; GO:0007424; GO:0045089; GO:0004872; GO:0007431 basal plasma membrane; calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; defense response to Gram-negative bacterium; establishment of planar polarity of follicular epithelium; establishment or maintenance of actin cytoskeleton polarity; focal adhesion; foregut morphogenesis; growth of a germarium-derived egg chamber; hindgut morphogenesis; homophilic cell adhesion; integral to plasma membrane; negative regulation of imaginal disc growth; open tracheal system development; positive regulation of innate immune response; receptor activity; salivary gland development IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Fat-like cadherin-related tumor suppressor homolog (Protein kugelei) kug fat2 CG7749 Drosophila melanogaster (Fruit fly) TR19852_c0_g2_i1 Q92010 ZF161_CHICK 2.00E-12 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 5) (ZF5) ZBTB14 ZFP161 Gallus gallus (Chicken) TR19873_c2_g1_i1 Q6UWR7 ENPP6_HUMAN 2.00E-15 GO:0031225; GO:0019695; GO:0005576; GO:0047390; GO:0008889; GO:0016042; GO:0006629; GO:0005886 anchored to membrane; choline metabolic process; extracellular region; glycerophosphocholine cholinephosphodiesterase activity; glycerophosphodiester phosphodiesterase activity; lipid catabolic process; lipid metabolic process; plasma membrane IPR017849; IPR017850; IPR024873; IPR002591; Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 (E-NPP 6) (NPP-6) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Glycerophosphocholine cholinephosphodiesterase) (GPC-Cpde) ENPP6 UNQ1889/PRO4334 Homo sapiens (Human) TR19873_c3_g1_i1 P84039 ENPP5_RAT 5.00E-24 GO:0007154; GO:0016787; GO:0016021; GO:0005886 cell communication; hydrolase activity; integral to membrane; plasma membrane IPR017849; IPR017850; IPR024873; IPR002591; Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (E-NPP 5) (NPP-5) (EC 3.1.-.-) Enpp5 Rattus norvegicus (Rat) TR19875_c0_g1_i1 Q8N587 ZN561_HUMAN 4.00E-09 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 561 ZNF561 Homo sapiens (Human) TR19879_c0_g1_i2 B1WB06 MET24_XENTR 7.00E-14 GO:0005576; GO:0008168 extracellular region; methyltransferase activity IPR025714; IPR026913; Methyltransferase-like protein 24 (EC 2.1.1.-) mettl24 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR1988_c0_g1_i1 Q08830 FGL1_HUMAN 4.00E-32 GO:0005577; GO:0035634 fibrinogen complex; response to stilbenoid IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein 1 (HP-041) (Hepassocin) (Hepatocyte-derived fibrinogen-related protein 1) (HFREP-1) (Liver fibrinogen-related protein 1) (LFIRE-1) FGL1 HFREP1 Homo sapiens (Human) TR19880_c2_g1_i1 P05934 CALM_STRPU 1.00E-16 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) (Fragment) Strongylocentrotus purpuratus (Purple sea urchin) TR19883_c2_g1_i1 Q8GSM3 LOX22_HORVU 3.00E-14 GO:0009507; GO:0005506; GO:0016165; GO:0031408 chloroplast; iron ion binding; linoleate 13S-lipoxygenase activity; oxylipin biosynthetic process IPR008976; IPR000907; IPR013819; IPR020834; IPR020833; IPR001246; IPR027433; IPR001024; Lipid metabolism; oxylipin biosynthesis. "Lipoxygenase 2.2, chloroplastic (EC 1.13.11.12) (LOX2:Hv:2)" LOX2.2 Hordeum vulgare (Barley) TR19884_c0_g1_i1 P82931 RT06_BOVIN 2.00E-23 GO:0005739; GO:0019843; GO:0005840; GO:0003735; GO:0006412 mitochondrion; rRNA binding; ribosome; structural constituent of ribosome; translation IPR000529; IPR014717; "28S ribosomal protein S6, mitochondrial (MRP-S6) (S6mt)" MRPS6 RPMS6 Bos taurus (Bovine) TR19900_c1_g2_i1 P29590 PML_HUMAN 6.00E-07 GO:0003677; GO:0006977; GO:0016605; GO:0030578; GO:0007184; GO:0006919; GO:0006915; GO:0060444; GO:0007050; GO:0045165; GO:0071353; GO:0090398; GO:0050897; GO:0007182; GO:0005737; GO:0005829; GO:0051607; GO:0031901; GO:0032469; GO:0042406; GO:0060333; GO:0008630; GO:0042771; GO:0051457; GO:0019048; GO:0030099; GO:0016525; GO:0030308; GO:0008285; GO:0045930; GO:2000059; GO:0051974; GO:0032211; GO:0045892; GO:0032938; GO:0016363; GO:0031965; GO:0005730; GO:0005634; GO:0060058; GO:0002230; GO:2001238; GO:0031065; GO:0043161; GO:0006461; GO:0046982; GO:0050821; GO:0006605; GO:0045343; GO:0010522; GO:2000779; GO:0001932; GO:0009411; GO:0010332; GO:0001666; GO:0048384; GO:0003713; GO:0006351; GO:0007179; GO:0008270 P03243-1; P04489; P27958; P68400; Q9UER7; P25445; Q9Y2M5; Q13164; Q00987; P25788; P63165; Q13207; O14746; Q15583; P04637; Q05516 "DNA binding; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; PML body; PML body organization; SMAD protein import into nucleus; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; branching involved in mammary gland duct morphogenesis; cell cycle arrest; cell fate commitment; cellular response to interleukin-4; cellular senescence; cobalt ion binding; common-partner SMAD protein phosphorylation; cytoplasm; cytosol; defense response to virus; early endosome membrane; endoplasmic reticulum calcium ion homeostasis; extrinsic to endoplasmic reticulum membrane; interferon-gamma-mediated signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; maintenance of protein location in nucleus; modulation by virus of host morphology or physiology; myeloid cell differentiation; negative regulation of angiogenesis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of mitotic cell cycle; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; negative regulation of telomerase activity; negative regulation of telomere maintenance via telomerase; negative regulation of transcription, DNA-dependent; negative regulation of translation in response to oxidative stress; nuclear matrix; nuclear membrane; nucleolus; nucleus; positive regulation of apoptotic process involved in mammary gland involution; positive regulation of defense response to virus by host; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of histone deacetylation; proteasomal ubiquitin-dependent protein catabolic process; protein complex assembly; protein heterodimerization activity; protein stabilization; protein targeting; regulation of MHC class I biosynthetic process; regulation of calcium ion transport into cytosol; regulation of double-strand break repair; regulation of protein phosphorylation; response to UV; response to gamma radiation; response to hypoxia; retinoic acid receptor signaling pathway; transcription coactivator activity; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; zinc ion binding" IPR021978; IPR000315; IPR001841; IPR013083; IPR017907; Protein PML (Promyelocytic leukemia protein) (RING finger protein 71) (Tripartite motif-containing protein 19) PML MYL PP8675 RNF71 TRIM19 Homo sapiens (Human) TR19903_c1_g1_i1 P98072 ENTK_BOVIN 3.00E-08 GO:0016021; GO:0006508; GO:0005044; GO:0004252 integral to membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity IPR008985; IPR000859; IPR023415; IPR002172; IPR000998; IPR011163; IPR001254; IPR018114; IPR001314; IPR000082; IPR001190; IPR017448; IPR009003; Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain] TMPRSS15 ENTK PRSS7 Bos taurus (Bovine) TR19904_c0_g1_i1 Q53F39 MPPE1_HUMAN 8.00E-21 GO:0006888; GO:0034235; GO:0006506; GO:0005794; GO:0005801; GO:0070971; GO:0005793; GO:0033116; GO:0016021; GO:0030145; GO:0008081 ER to Golgi vesicle-mediated transport; GPI anchor binding; GPI anchor biosynthetic process; Golgi apparatus; cis-Golgi network; endoplasmic reticulum exit site; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; manganese ion binding; phosphoric diester hydrolase activity IPR024654; Metallophosphoesterase 1 (EC 3.1.-.-) (Post-GPI attachment to proteins factor 5) MPPE1 PGAP5 PP579 Homo sapiens (Human) TR19904_c2_g2_i1 B1WC86 MPPE1_RAT 1.00E-22 GO:0006888; GO:0034235; GO:0006506; GO:0005794; GO:0005801; GO:0070971; GO:0005793; GO:0033116; GO:0016021; GO:0030145; GO:0008081 ER to Golgi vesicle-mediated transport; GPI anchor binding; GPI anchor biosynthetic process; Golgi apparatus; cis-Golgi network; endoplasmic reticulum exit site; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; manganese ion binding; phosphoric diester hydrolase activity IPR004843; Metallophosphoesterase 1 (EC 3.1.-.-) (Post-GPI attachment to proteins factor 5) Mppe1 Pgap5 Rattus norvegicus (Rat) TR19904_c2_g3_i1 C7G3A0 MPPE1_CRIGR 1.00E-24 GO:0006888; GO:0034235; GO:0006506; GO:0005794; GO:0005801; GO:0070971; GO:0005793; GO:0033116; GO:0016021; GO:0030145; GO:0008081 ER to Golgi vesicle-mediated transport; GPI anchor binding; GPI anchor biosynthetic process; Golgi apparatus; cis-Golgi network; endoplasmic reticulum exit site; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; manganese ion binding; phosphoric diester hydrolase activity IPR024654; Metallophosphoesterase 1 (EC 3.1.-.-) (Post-GPI attachment to proteins factor 5) MPPE1 PGAP5 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR19910_c0_g1_i1 O60522 TDRD6_HUMAN 6.00E-10 GO:0043186; GO:0033391; GO:0005783; GO:0007281; GO:0007275; GO:0007283 P granule; chromatoid body; endoplasmic reticulum; germ cell development; multicellular organismal development; spermatogenesis IPR002999; Tudor domain-containing protein 6 (Antigen NY-CO-45) (Cancer/testis antigen 41.2) (CT41.2) TDRD6 Homo sapiens (Human) TR19910_c1_g1_i1 Q58EK5 TDRD1_DANRE 3.00E-28 GO:0043046; GO:0031047; GO:0007281; GO:0007126; GO:0046872; GO:0007275; GO:0071546; GO:0034587; GO:0007283 Q8UVX0; A2CEI6 DNA methylation involved in gamete generation; gene silencing by RNA; germ cell development; meiosis; metal ion binding; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002999; IPR002893; Tudor domain-containing protein 1 tdrd1 im:7155161 Danio rerio (Zebrafish) (Brachydanio rerio) TR19917_c2_g1_i1 Q8BXX2 ZBT49_MOUSE 1.00E-11 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) Zbtb49 Zfp509 Znf509 Mus musculus (Mouse) TR19924_c0_g1_i1 Q6NT16 S18B1_HUMAN 3.00E-14 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR020846; IPR016196; MFS-type transporter SLC18B1 (Solute carrier family 18 member B1) SLC18B1 C6orf192 Homo sapiens (Human) TR19925_c0_g1_i1 Q460N3 PAR15_HUMAN 1.00E-12 GO:0003950; GO:0005634; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) TR19925_c0_g2_i1 Q8C1B2 PARPT_MOUSE 5.00E-23 GO:0003950; GO:0008209; GO:0008210; GO:0060325; GO:0008585; GO:0030097; GO:0001822; GO:0046872; GO:0044236; GO:0006807; GO:0060021; GO:0048008; GO:0009791; GO:0006471; GO:0048705; GO:0048745; GO:0001570 NAD+ ADP-ribosyltransferase activity; androgen metabolic process; estrogen metabolic process; face morphogenesis; female gonad development; hemopoiesis; kidney development; metal ion binding; multicellular organismal metabolic process; nitrogen compound metabolic process; palate development; platelet-derived growth factor receptor signaling pathway; post-embryonic development; protein ADP-ribosylation; skeletal system morphogenesis; smooth muscle tissue development; vasculogenesis IPR012317; IPR004170; IPR000571; TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) Tiparp Mus musculus (Mouse) TR19927_c1_g1_i1 Q0PMG2 MDGA1_MOUSE 8.00E-21 GO:0046658; GO:0021799; GO:0001764 anchored to plasma membrane; cerebral cortex radially oriented cell migration; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 Mdga1 Mus musculus (Mouse) TR19931_c0_g1_i1 Q3ZBG9 PLS2_BOVIN 4.00E-42 GO:0016021; GO:0046872 integral to membrane; metal ion binding IPR005552; Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) TR19933_c0_g1_i1 Q49MI3 CERKL_HUMAN 4.00E-17 GO:0005794; GO:0003951; GO:0004143; GO:0005783; GO:0043066; GO:0005730; GO:0007205 Golgi apparatus; NAD+ kinase activity; diacylglycerol kinase activity; endoplasmic reticulum; negative regulation of apoptotic process; nucleolus; protein kinase C-activating G-protein coupled receptor signaling pathway IPR016064; IPR001206; Ceramide kinase-like protein CERKL Homo sapiens (Human) TR19934_c1_g1_i2 Q3V2K1 CX065_MOUSE 8.00E-10 Uncharacterized protein CXorf65 homolog Gm614 Mus musculus (Mouse) TR19937_c1_g2_i1 O43313 ATMIN_HUMAN 5.00E-22 GO:0046872; GO:0005634; GO:0045893; GO:0006974; GO:0044212; GO:0006351 Q13315 "metal ion binding; nucleus; positive regulation of transcription, DNA-dependent; response to DNA damage stimulus; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR007087; IPR015880; ATM interactor (ATM/ATR-substrate CHK2-interacting zinc finger protein) (ASCIZ) (Zinc finger protein 822) ATMIN KIAA0431 ZNF822 Homo sapiens (Human) TR19939_c0_g1_i1 Q8IYX0 ZN679_HUMAN 1.00E-24 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 679 ZNF679 Homo sapiens (Human) TR19939_c0_g2_i1 Q8N9F8 ZN454_HUMAN 1.00E-28 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 454 ZNF454 Homo sapiens (Human) TR19939_c1_g1_i1 Q3UH06 RREB1_MOUSE 4.00E-11 GO:0003677; GO:0046872; GO:0045892; GO:0016607; GO:0003700; GO:0006351 "DNA binding; metal ion binding; negative regulation of transcription, DNA-dependent; nuclear speck; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Ras-responsive element-binding protein 1 (RREB-1) (RAS-responsive zinc finger transcription factor RREB) Rreb1 Mus musculus (Mouse) TR19944_c0_g1_i1 Q8JGT9 CRVP_RHATT 7.00E-24 GO:0005576 extracellular region IPR001283; IPR018244; IPR014044; IPR013871; IPR003582; Cysteine-rich venom protein tigrin (CRVP) (Cysteine-rich secretory protein RHA1) (CRISP-RHA1) Rhabdophis tigrinus tigrinus (Tiger keelback snake) TR19944_c0_g1_i2 A6QLZ7 CRLD2_BOVIN 7.00E-31 GO:0005576; GO:0030133 extracellular region; transport vesicle IPR001283; IPR018244; IPR014044; IPR004043; Cysteine-rich secretory protein LCCL domain-containing 2 CRISPLD2 Bos taurus (Bovine) TR19945_c2_g1_i1 Q9P2F6 RHG20_HUMAN 1.00E-11 GO:0005096; GO:0005829; GO:0005543; GO:0043547; GO:0051056; GO:0007264 GTPase activator activity; cytosol; phospholipid binding; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR011993; IPR001849; IPR000159; IPR008936; IPR000198; Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20) ARHGAP20 KIAA1391 Homo sapiens (Human) TR19947_c0_g1_i1 Q8WWF8 CAPSL_HUMAN 2.00E-23 GO:0005509; GO:0005737 calcium ion binding; cytoplasm IPR011992; IPR018247; IPR002048; IPR001125; Calcyphosin-like protein CAPSL Homo sapiens (Human) TR19947_c0_g3_i1 Q9ZSA3 CDPKM_ARATH 2.00E-08 GO:0005524; GO:0005509; GO:0016020; GO:0004674 ATP binding; calcium ion binding; membrane; protein serine/threonine kinase activity IPR011992; IPR018247; IPR002048; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium-dependent protein kinase 22 (EC 2.7.11.1) CPK22 At4g04710 T4B21.12 Arabidopsis thaliana (Mouse-ear cress) TR19949_c1_g1_i1 P34935 GRP78_PIG 1.00E-26 GO:0005524; GO:0005788; GO:0042470 ATP binding; endoplasmic reticulum lumen; melanosome IPR018181; IPR013126; 78 kDa glucose-regulated protein (GRP-78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP) (Fragment) HSPA5 GRP78 Sus scrofa (Pig) TR19949_c2_g1_i1 P20029 GRP78_MOUSE 4.00E-53 GO:0005524; GO:0008180; GO:0006983; GO:0006987; GO:0009986; GO:0042149; GO:0071353; GO:0021680; GO:0021589; GO:0034663; GO:0005788; GO:0005793; GO:0005576; GO:0030176; GO:0042470; GO:0030496; GO:0051787; GO:0043066; GO:0030512; GO:0040019; GO:0031398; GO:0051603; GO:0043022 O75460 ATP binding; COP9 signalosome; ER overload response; activation of signaling protein activity involved in unfolded protein response; cell surface; cellular response to glucose starvation; cellular response to interleukin-4; cerebellar Purkinje cell layer development; cerebellum structural organization; endoplasmic reticulum chaperone complex; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment; extracellular region; integral to endoplasmic reticulum membrane; melanosome; midbody; misfolded protein binding; negative regulation of apoptotic process; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of embryonic development; positive regulation of protein ubiquitination; proteolysis involved in cellular protein catabolic process; ribosome binding IPR018181; IPR013126; 78 kDa glucose-regulated protein (GRP-78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP) Hspa5 Grp78 Mus musculus (Mouse) TR19951_c0_g1_i1 Q06807 TIE2_BOVIN 7.00E-11 GO:0005524; GO:0048014; GO:0005884; GO:0016324; GO:0009925; GO:0009986; GO:0005911; GO:0005737; GO:0001935; GO:0005576; GO:0005925; GO:0060347; GO:0005887; GO:0045121; GO:0005902; GO:0016525; GO:2000352; GO:0070374; GO:2000251; GO:0045766; GO:0010595; GO:0051894; GO:0043552; GO:0014068; GO:0051897; GO:0001934; GO:0046777; GO:0051259; GO:0004713; GO:0032878; GO:0002040; GO:0001725; GO:0034446; GO:0004714 ATP binding; Tie signaling pathway; actin filament; apical plasma membrane; basal plasma membrane; cell surface; cell-cell junction; cytoplasm; endothelial cell proliferation; extracellular region; focal adhesion; heart trabecula formation; integral to plasma membrane; membrane raft; microvillus; negative regulation of angiogenesis; negative regulation of endothelial cell apoptotic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of actin cytoskeleton reorganization; positive regulation of angiogenesis; positive regulation of endothelial cell migration; positive regulation of focal adhesion assembly; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of protein phosphorylation; protein autophosphorylation; protein oligomerization; protein tyrosine kinase activity; regulation of establishment or maintenance of cell polarity; sprouting angiogenesis; stress fiber; substrate adhesion-dependent cell spreading; transmembrane receptor protein tyrosine kinase activity IPR000742; IPR013032; IPR002049; IPR003961; IPR007110; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR018941; IPR008266; IPR020635; Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TIE-2) (CD antigen CD202b) TEK TIE-2 TIE2 Bos taurus (Bovine) TR19957_c2_g2_i1 Q5RF73 TMM19_PONAB 2.00E-55 GO:0016021 integral to membrane IPR002794; Transmembrane protein 19 TMEM19 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR19961_c0_g2_i1 Q9HDD0 HRSL1_HUMAN 9.00E-15 GO:0046485; GO:0016021; GO:0016042; GO:0005641; GO:0005777; GO:0007031; GO:0004620; GO:0016740 ether lipid metabolic process; integral to membrane; lipid catabolic process; nuclear envelope lumen; peroxisome; peroxisome organization; phospholipase activity; transferase activity IPR007053; Phospholipid-metabolizing enzyme A-C1 (EC 2.3.1.-) (EC 3.1.1.-) (HRAS-like suppressor 1) (HRSL1) HRASLS Homo sapiens (Human) TR19965_c0_g1_i1 P20481 BUCC_APLCA 6.00E-11 GO:0005576; GO:0007218 extracellular region; neuropeptide signaling pathway Buccalin [Cleaved into: Buccalin-D; Buccalin-E; Buccalin-F; Buccalin-G; Buccalin-H; Buccalin-A; Buccalin-I; Buccalin-J; Buccalin-K; Buccalin-L; Buccalin-B (BUCb); Buccalin-M; Buccalin gene-predicted acidic peptide A (BGPAP A); Buccalin-N; Buccalin-O; Buccalin-P; Buccalin-Q; Buccalin-R; Buccalin-C; Buccalin-S; Buccalin gene-predicted acidic peptide B (BGPAP B)] Aplysia californica (California sea hare) TR19970_c0_g1_i1 O83142 5NTD_TREPA 7.00E-08 GO:0008253; GO:0046872; GO:0000166; GO:0009166; GO:0005886 5'-nucleotidase activity; metal ion binding; nucleotide binding; nucleotide catabolic process; plasma membrane IPR008334; IPR006146; IPR006179; IPR006420; IPR004843; Probable 5'-nucleotidase (EC 3.1.3.5) TP_0104 Treponema pallidum (strain Nichols) TR19971_c0_g1_i1 Q9JM83 CALM4_MOUSE 1.00E-10 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-4 (Calcium-binding protein Dd112) Calm4 Dd112 Mus musculus (Mouse) TR19983_c2_g1_i1 Q8BI22 CE128_MOUSE 7.00E-08 GO:0005814; GO:0000922 centriole; spindle pole Centrosomal protein of 128 kDa (Cep128) Cep128 Mus musculus (Mouse) TR19984_c1_g1_i2 A5PJY4 TM138_BOVIN 1.00E-43 GO:0005929; GO:0042384; GO:0016021; GO:0005774 cilium; cilium assembly; integral to membrane; vacuolar membrane IPR024133; Transmembrane protein 138 TMEM138 Bos taurus (Bovine) TR19985_c1_g1_i1 Q9VB31 C6A18_DROME 1.00E-06 GO:0005789; GO:0020037; GO:0005506; GO:0004497; GO:0016705 "endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Probable cytochrome P450 6a18 (EC 1.14.-.-) (CYPVIA18) Cyp6a18 CG13977 Drosophila melanogaster (Fruit fly) TR19988_c1_g1_i1 A3KMI0 DHX29_XENLA 1.00E-10 GO:0005524; GO:0008026; GO:0016282; GO:0043024; GO:0003743 ATP binding; ATP-dependent helicase activity; eukaryotic 43S preinitiation complex; ribosomal small subunit binding; translation initiation factor activity IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; ATP-dependent RNA helicase DHX29 (EC 3.6.4.13) (DEAH box protein 29) dhx29 Xenopus laevis (African clawed frog) TR19993_c0_g1_i1 A0JNC4 ELOV7_BOVIN 2.00E-26 GO:0005783; GO:0005789; GO:0034626; GO:0019367; GO:0016021; GO:0016740; GO:0042761 "endoplasmic reticulum; endoplasmic reticulum membrane; fatty acid elongation, polyunsaturated fatty acid; fatty acid elongation, saturated fatty acid; integral to membrane; transferase activity; very long-chain fatty acid biosynthetic process" IPR002076; Elongation of very long chain fatty acids protein 7 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL7) (ELOVL fatty acid elongase 7) (ELOVL FA elongase 7) (Very-long-chain 3-oxoacyl-CoA synthase 7) ELOVL7 Bos taurus (Bovine) TR19994_c0_g1_i1 Q8MJU1 CASP3_FELCA 4.00E-07 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Felis catus (Cat) (Felis silvestris catus) TR19995_c0_g1_i1 P48305 NDUB4_BOVIN 2.00E-08 GO:0008137; GO:0016021; GO:0005743; GO:0070469; GO:0006979 NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial inner membrane; respiratory chain; response to oxidative stress IPR009866; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (Complex I-B15) (CI-B15) (NADH-ubiquinone oxidoreductase B15 subunit) NDUFB4 Bos taurus (Bovine) TR19999_c2_g1_i1 Q96K83 ZN521_HUMAN 3.00E-43 GO:0003677; GO:0030154; GO:0046872; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cell differentiation; metal ion binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 521 (Early hematopoietic zinc finger protein) (LYST-interacting protein 3) ZNF521 EHZF LIP3 Homo sapiens (Human) TR20002_c0_g1_i1 Q9QZZ4 MYO15_MOUSE 2.00E-42 GO:0005524; GO:0005737; GO:0042472; GO:0007626; GO:0003774; GO:0016459; GO:0007605; GO:0032420 Q80VW5 ATP binding; cytoplasm; inner ear morphogenesis; locomotory behavior; motor activity; myosin complex; sensory perception of sound; stereocilium IPR019749; IPR019748; IPR000299; IPR000048; IPR001609; IPR000857; IPR027417; IPR011511; IPR001452; Unconventional myosin-XV (Unconventional myosin-15) Myo15a Myo15 Mus musculus (Mouse) TR20002_c0_g2_i1 Q9UKN7 MYO15_HUMAN 4.00E-44 GO:0005524; GO:0005737; GO:0042472; GO:0007626; GO:0003774; GO:0016459; GO:0007605; GO:0032420 ATP binding; cytoplasm; inner ear morphogenesis; locomotory behavior; motor activity; myosin complex; sensory perception of sound; stereocilium IPR019749; IPR019748; IPR000299; IPR000048; IPR001609; IPR000857; IPR027417; IPR011511; IPR001452; Unconventional myosin-XV (Unconventional myosin-15) MYO15A MYO15 Homo sapiens (Human) TR20003_c3_g1_i1 Q624D2 EFN4_CAEBR 2.00E-06 GO:0031225; GO:0007275; GO:0005886 anchored to membrane; multicellular organismal development; plasma membrane IPR008972; IPR001799; Ephrin-4 efn-4 CBG01610 Caenorhabditis briggsae TR20014_c0_g1_i1 Q8NB25 F184A_HUMAN 7.00E-19 Protein FAM184A FAM184A C6orf60 Homo sapiens (Human) TR20014_c1_g1_i1 Q9ULE4 F184B_HUMAN 3.00E-10 Protein FAM184B FAM184B KIAA1276 Homo sapiens (Human) TR20019_c0_g1_i1 O80763 NRX1_ARATH 1.00E-08 GO:0045454; GO:0005829; GO:0009860; GO:0010183; GO:0047134; GO:0080092; GO:0046686 cell redox homeostasis; cytosol; pollen tube growth; pollen tube guidance; protein-disulfide reductase activity; regulation of pollen tube growth; response to cadmium ion IPR011424; IPR012336; IPR017937; Probable nucleoredoxin 1 (AtNrx1) (EC 1.8.1.8) At1g60420 T13D8.29 Arabidopsis thaliana (Mouse-ear cress) TR20026_c1_g1_i1 Q8TC84 FANK1_HUMAN 5.00E-76 GO:0005737; GO:0005634 cytoplasm; nucleus IPR002110; IPR020683; IPR003961; IPR013783; Fibronectin type 3 and ankyrin repeat domains protein 1 FANK1 HSD13 UNQ6504/PRO21382 Homo sapiens (Human) TR20026_c2_g1_i1 Q91955 MTPN_CHICK 6.00E-08 GO:0030424; GO:0005829; GO:0005634; GO:0048471; GO:0051092; GO:0010613; GO:0030307; GO:0010557; GO:0051247; GO:2000812 axon; cytosol; nucleus; perinuclear region of cytoplasm; positive regulation of NF-kappaB transcription factor activity; positive regulation of cardiac muscle hypertrophy; positive regulation of cell growth; positive regulation of macromolecule biosynthetic process; positive regulation of protein metabolic process; regulation of barbed-end actin filament capping IPR002110; IPR020683; Myotrophin (Granule cell differentiation protein) (Protein V-1) MTPN RCJMB04_23o21 RCJMB04_35l16 Gallus gallus (Chicken) TR20034_c0_g1_i1 Q6HAA2 CTSP2_CRODU 3.00E-06 GO:0006952; GO:0005576 defense response; extracellular region IPR001855; Crotasin Cts-p2 Crotalus durissus terrificus (South American rattlesnake) TR20037_c1_g2_i2 Q6WRI0 IGS10_HUMAN 4.00E-11 GO:0030154; GO:0005576; GO:0007275; GO:0001503 cell differentiation; extracellular region; multicellular organismal development; ossification IPR000483; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR003591; IPR000372; Immunoglobulin superfamily member 10 (IgSF10) (Calvaria mechanical force protein 608) (CMF608) IGSF10 CMF608 Homo sapiens (Human) TR20043_c1_g1_i1 O75594 PGRP1_HUMAN 2.00E-20 GO:0008745; GO:0050830; GO:0016045; GO:0005576; GO:0044117; GO:0045087; GO:0032689; GO:0032827; GO:0042834; GO:0009253; GO:0016019; GO:0008270 N-acetylmuramoyl-L-alanine amidase activity; defense response to Gram-positive bacterium; detection of bacterium; extracellular region; growth of symbiont in host; innate immune response; negative regulation of interferon-gamma production; negative regulation of natural killer cell differentiation involved in immune response; peptidoglycan binding; peptidoglycan catabolic process; peptidoglycan receptor activity; zinc ion binding IPR002502; IPR017331; IPR015510; IPR006619; Peptidoglycan recognition protein 1 (Peptidoglycan recognition protein short) (PGRP-S) PGLYRP1 PGLYRP PGRP TNFSF3L SBBI68 UNQ639/PRO1269 Homo sapiens (Human) TR20044_c0_g1_i1 P07190 MAL2_DROME 1.00E-18 GO:0005975; GO:0043169; GO:0032450 carbohydrate metabolic process; cation binding; maltose alpha-glucosidase activity IPR015902; IPR006047; IPR006589; IPR013781; IPR017853; Probable maltase H (EC 3.2.1.20) (Larval visceral protein H) LvpH CG8696 Drosophila melanogaster (Fruit fly) TR20048_c1_g1_i1 Q28691 PE2R4_RABIT 3.00E-27 GO:0042093; GO:0007188; GO:0071260; GO:0016021; GO:0050710; GO:2000420; GO:0050728; GO:0033624; GO:0005886; GO:0050715; GO:0050729; GO:0004957; GO:0051492 T-helper cell differentiation; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; cellular response to mechanical stimulus; integral to membrane; negative regulation of cytokine secretion; negative regulation of eosinophil extravasation; negative regulation of inflammatory response; negative regulation of integrin activation; plasma membrane; positive regulation of cytokine secretion; positive regulation of inflammatory response; prostaglandin E receptor activity; regulation of stress fiber assembly IPR000276; IPR017452; IPR001758; IPR008365; IPR001244; Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 Oryctolagus cuniculus (Rabbit) TR20050_c0_g1_i1 Q17QS1 SNX24_BOVIN 2.00E-25 GO:0007154; GO:0030659; GO:0035091; GO:0015031 cell communication; cytoplasmic vesicle membrane; phosphatidylinositol binding; protein transport IPR001683; Sorting nexin-24 SNX24 Bos taurus (Bovine) TR20052_c1_g2_i1 Q02067 ASCL1_MOUSE 1.00E-25 GO:0070888; GO:0007219; GO:0061104; GO:0061103; GO:0048469; GO:0071259; GO:0021954; GO:0021892; GO:0021987; GO:0021902; GO:0003690; GO:0048484; GO:0061100; GO:0050883; GO:0043066; GO:0045665; GO:0045892; GO:0007400; GO:0007405; GO:0048665; GO:0001764; GO:0043025; GO:0003359; GO:0005634; GO:0060166; GO:0014003; GO:0048486; GO:0007389; GO:0045747; GO:0045787; GO:2000179; GO:0050769; GO:0043525; GO:0045666; GO:0045944; GO:0007346; GO:0060165; GO:0070849; GO:0051593; GO:0010226; GO:0032526; GO:0043565; GO:0003700; GO:0021527; GO:0021530; GO:0061102; GO:0060163; GO:0048485; GO:0000989; GO:0006351; GO:0021750 "E-box binding; Notch signaling pathway; adrenal chromaffin cell differentiation; carotid body glomus cell differentiation; cell maturation; cellular response to magnetism; central nervous system neuron development; cerebral cortex GABAergic interneuron differentiation; cerebral cortex development; commitment of neuronal cell to specific neuron type in forebrain; double-stranded DNA binding; enteric nervous system development; lung neuroendocrine cell differentiation; musculoskeletal movement, spinal reflex action; negative regulation of apoptotic process; negative regulation of neuron differentiation; negative regulation of transcription, DNA-dependent; neuroblast fate determination; neuroblast proliferation; neuron fate specification; neuron migration; neuronal cell body; noradrenergic neuron fate commitment; nucleus; olfactory pit development; oligodendrocyte development; parasympathetic nervous system development; pattern specification process; positive regulation of Notch signaling pathway; positive regulation of cell cycle; positive regulation of neural precursor cell proliferation; positive regulation of neurogenesis; positive regulation of neuron apoptotic process; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of mitotic cell cycle; regulation of timing of subpallium neuron differentiation; response to epidermal growth factor stimulus; response to folic acid; response to lithium ion; response to retinoic acid; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; spinal cord association neuron differentiation; spinal cord oligodendrocyte cell fate specification; stomach neuroendocrine cell differentiation; subpallium neuron fate commitment; sympathetic nervous system development; transcription factor binding transcription factor activity; transcription, DNA-dependent; vestibular nucleus development" IPR015660; IPR011598; Achaete-scute homolog 1 (ASH-1) (mASH-1) (mASH1) Ascl1 Ash1 Mash-1 Mash1 Mus musculus (Mouse) TR20052_c1_g3_i1 Q2EGB9 ASCL2_BOVIN 6.00E-17 GO:0070888; GO:0030154; GO:0005737; GO:0000122; GO:0007399; GO:0005634; GO:0001666; GO:0060712; GO:0006351 "E-box binding; cell differentiation; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; nervous system development; nucleus; response to hypoxia; spongiotrophoblast layer development; transcription, DNA-dependent" IPR015660; IPR011598; Achaete-scute homolog 2 (Mash2) ASCL2 MASH2 Bos taurus (Bovine) TR20057_c0_g1_i3 A4FUZ6 HSDL2_BOVIN 1.00E-07 GO:0016491; GO:0005777; GO:0032934 oxidoreductase activity; peroxisome; sterol binding IPR002198; IPR002347; IPR016040; IPR003033; Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-) HSDL2 Bos taurus (Bovine) TR20057_c0_g1_i4 Q4L8Y1 Y0585_STAHJ 2.00E-36 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; Uncharacterized oxidoreductase SH0585 (EC 1.-.-.-) SH0585 Staphylococcus haemolyticus (strain JCSC1435) TR20057_c0_g1_i5 Q49WS9 Y1627_STAS1 2.00E-44 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Uncharacterized oxidoreductase SSP1627 (EC 1.-.-.-) SSP1627 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) TR20061_c3_g1_i1 Q4H4B6 SCRIB_DANRE 2.00E-19 GO:0032863; GO:0060561; GO:0008283; GO:0005913; GO:0016337; GO:0060027; GO:0005737; GO:0035089; GO:0000132; GO:0045930; GO:0001764; GO:0005886; GO:0050918; GO:0043065; GO:0014021 activation of Rac GTPase activity; apoptotic process involved in morphogenesis; cell proliferation; cell-cell adherens junction; cell-cell adhesion; convergent extension involved in gastrulation; cytoplasm; establishment of apical/basal cell polarity; establishment of mitotic spindle orientation; negative regulation of mitotic cell cycle; neuron migration; plasma membrane; positive chemotaxis; positive regulation of apoptotic process; secondary neural tube formation IPR001611; IPR025875; IPR003591; IPR001478; Protein scribble homolog (Scribble1) scrib llk scrb1 Danio rerio (Zebrafish) (Brachydanio rerio) TR20067_c0_g1_i1 Q6QNK2 GP133_HUMAN 2.00E-07 GO:0004930; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR008985; IPR013320; IPR017981; IPR000832; IPR017983; IPR000203; Probable G-protein coupled receptor 133 (G-protein coupled receptor PGR25) GPR133 PGR25 Homo sapiens (Human) TR20067_c0_g2_i1 O14514 BAI1_HUMAN 1.00E-17 GO:0004930; GO:0007409; GO:0007155; GO:0005911; GO:0005887; GO:0016525; GO:0008285; GO:0007218; GO:0007422 G-protein coupled receptor activity; axonogenesis; cell adhesion; cell-cell junction; integral to plasma membrane; negative regulation of angiogenesis; negative regulation of cell proliferation; neuropeptide signaling pathway; peripheral nervous system development IPR022624; IPR017981; IPR008077; IPR001879; IPR000832; IPR000203; IPR000884; Brain-specific angiogenesis inhibitor 1 BAI1 Homo sapiens (Human) TR20067_c1_g1_i1 Q58Y75 GP113_MOUSE 2.00E-07 GO:0004930; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR001879; IPR000832; IPR017983; IPR000203; Probable G-protein coupled receptor 113 (G-protein coupled receptor PGR23) Gpr113 Gm1041 Pcr113 Pgr23 Mus musculus (Mouse) TR20067_c1_g1_i2 Q80T32 GP133_MOUSE 2.00E-08 GO:0004930; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR008985; IPR013320; IPR017981; IPR000832; IPR017983; IPR000203; Probable G-protein coupled receptor 133 (G-protein coupled receptor PGR25) Gpr133 Pgr25 Mus musculus (Mouse) TR20068_c1_g2_i1 P21329 RTJK_DROFU 7.00E-11 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) TR20070_c4_g1_i1 Q8R511 FNBP1_RAT 3.00E-09 GO:0005938; GO:0030154; GO:0005905; GO:0016023; GO:0005856; GO:0006897; GO:0008289; GO:0005764; GO:0007399; GO:0005886 P18545; P52198; O00401 cell cortex; cell differentiation; coated pit; cytoplasmic membrane-bounded vesicle; cytoskeleton; endocytosis; lipid binding; lysosome; nervous system development; plasma membrane IPR001060; IPR001452; Formin-binding protein 1 (Formin-binding protein 17) (Rapostlin) Fnbp1 Fbp17 Rattus norvegicus (Rat) TR20070_c5_g1_i1 Q6PFY1 FCSD1_MOUSE 3.00E-18 IPR001060; IPR001452; FCH and double SH3 domains protein 1 Fchsd1 Mus musculus (Mouse) TR20071_c1_g1_i1 Q640L5 CCD18_MOUSE 1.00E-08 Coiled-coil domain-containing protein 18 Ccdc18 Mus musculus (Mouse) TR20076_c1_g1_i1 Q01241 NF70_LOLPE 8.00E-06 GO:0005882; GO:0005198 intermediate filament; structural molecule activity IPR001664; IPR016451; IPR018039; IPR001322; 70 kDa neurofilament protein (NF70) Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR20083_c1_g1_i1 P49695 PKWA_THECU 2.00E-10 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR020472; IPR011009; IPR000719; IPR017441; IPR008271; IPR015943; IPR001680; IPR019775; IPR017986; Probable serine/threonine-protein kinase PkwA (EC 2.7.11.1) pkwA pkw1 Thermomonospora curvata TR20086_c1_g1_i1 Q4LDE5 SVEP1_HUMAN 4.00E-12 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) TR20086_c2_g2_i2 O35600 ABCA4_MOUSE 8.00E-24 GO:0005524; GO:0042626; GO:0005887; GO:0006649; GO:0004012; GO:0045494; GO:0050896; GO:0007601 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; integral to plasma membrane; phospholipid transfer to membrane; phospholipid-translocating ATPase activity; photoreceptor cell maintenance; response to stimulus; visual perception" IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; IPR005951; Retinal-specific ATP-binding cassette transporter (ATP-binding cassette sub-family A member 4) (RIM ABC transporter) (RIM protein) (RmP) Abca4 Abcr Mus musculus (Mouse) TR20093_c0_g2_i1 Q9Y234 LIPT_HUMAN 3.00E-12 GO:0006464; GO:0006629; GO:0005739; GO:0009249; GO:0016746 "cellular protein modification process; lipid metabolic process; mitochondrion; protein lipoylation; transferase activity, transferring acyl groups" IPR004143; IPR004562; Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2. "Lipoyltransferase 1, mitochondrial (EC 2.3.1.-) (Lipoate biosynthesis protein) (Lipoate-protein ligase) (Lipoyl ligase)" LIPT1 Homo sapiens (Human) TR20094_c0_g1_i2 O15164 TIF1A_HUMAN 4.00E-06 GO:0055074; GO:0071391; GO:0003682; GO:0005829; GO:0034056; GO:0070577; GO:0008285; GO:0045892; GO:0005719; GO:0005634; GO:0005726; GO:0045893; GO:0046777; GO:0030163; GO:0004672; GO:0005102; GO:0042981; GO:0031647; GO:0070562; GO:0043565; GO:0003713; GO:0006366; GO:0004842; GO:0008270 "calcium ion homeostasis; cellular response to estrogen stimulus; chromatin binding; cytosol; estrogen response element binding; histone acetyl-lysine binding; negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nucleus; perichromatin fibrils; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein catabolic process; protein kinase activity; receptor binding; regulation of apoptotic process; regulation of protein stability; regulation of vitamin D receptor signaling pathway; sequence-specific DNA binding; transcription coactivator activity; transcription from RNA polymerase II promoter; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR018359; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (Tripartite motif-containing protein 24) TRIM24 RNF82 TIF1 TIF1A Homo sapiens (Human) TR20098_c0_g1_i1 Q3UVY5 PCX4_MOUSE 8.00E-72 GO:0016021 integral to membrane IPR007735; Pecanex-like protein 4 Pcnxl4 Mus musculus (Mouse) TR20101_c1_g2_i1 Q8R0M8 MOT5_MOUSE 1.00E-09 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 5 (MCT 5) Slc16a4 Mct5 Mus musculus (Mouse) TR20107_c1_g2_i1 Q2TBX6 PSB1_BOVIN 7.00E-61 GO:0005737; GO:0005634; GO:0005839; GO:0051603; GO:0004298 cytoplasm; nucleus; proteasome core complex; proteolysis involved in cellular protein catabolic process; threonine-type endopeptidase activity IPR016050; IPR001353; IPR023333; Proteasome subunit beta type-1 (EC 3.4.25.1) PSMB1 Bos taurus (Bovine) TR20108_c1_g1_i1 Q8K0U4 HS12A_MOUSE 3.00E-14 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR20109_c0_g1_i1 A0JNC4 ELOV7_BOVIN 1.00E-50 GO:0005783; GO:0005789; GO:0034626; GO:0019367; GO:0016021; GO:0016740; GO:0042761 "endoplasmic reticulum; endoplasmic reticulum membrane; fatty acid elongation, polyunsaturated fatty acid; fatty acid elongation, saturated fatty acid; integral to membrane; transferase activity; very long-chain fatty acid biosynthetic process" IPR002076; Elongation of very long chain fatty acids protein 7 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL7) (ELOVL fatty acid elongase 7) (ELOVL FA elongase 7) (Very-long-chain 3-oxoacyl-CoA synthase 7) ELOVL7 Bos taurus (Bovine) TR20110_c0_g1_i1 Q9BYU1 PBX4_HUMAN 4.00E-07 GO:0001741; GO:0005634; GO:0045893; GO:0043565; GO:0003700; GO:0006366 "XY body; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter" IPR001356; IPR009057; IPR005542; Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4) PBX4 Homo sapiens (Human) TR20117_c0_g1_i1 Q9VE46 SC5A7_DROME 4.00E-58 GO:0008292; GO:0015171; GO:0015220; GO:0016021; GO:0006814; GO:0015293 acetylcholine biosynthetic process; amino acid transmembrane transporter activity; choline transmembrane transporter activity; integral to membrane; sodium ion transport; symporter activity IPR001734; High-affinity choline transporter 1 CG7708 Drosophila melanogaster (Fruit fly) TR20124_c1_g1_i1 P48057 SC6A1_MUSCO 4.00E-19 GO:0005332; GO:0005887; GO:0005328 gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR002980; Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) Slc6a1 Gabt1 Gat-1 Gat1 Mus cookii (Cook's mouse) TR20124_c2_g1_i1 A7Y2W8 SC6A9_XENLA 4.00E-25 GO:0005887; GO:0005328; GO:0005283 integral to plasma membrane; neurotransmitter:sodium symporter activity; sodium:amino acid symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9) slc6a9 glyt1 Xenopus laevis (African clawed frog) TR2013_c0_g1_i1 P86854 PLCL_MYTGA 7.00E-06 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR2014_c0_g1_i1 Q6AX44 FBCDA_XENLA 3.00E-19 GO:0008061; GO:0016021; GO:0046872 chitin binding; integral to membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1-A fibcd1-a Xenopus laevis (African clawed frog) TR20154_c1_g1_i1 Q6QI06 RICTR_MOUSE 1.00E-23 GO:0031929; GO:0031932; GO:0031532; GO:0009790; GO:0032008; GO:0030838; GO:0050731; GO:0032314; GO:0030334; GO:0051896; GO:0043022 Q9JLN9 TOR signaling cascade; TORC2 complex; actin cytoskeleton reorganization; embryo development; positive regulation of TOR signaling cascade; positive regulation of actin filament polymerization; positive regulation of peptidyl-tyrosine phosphorylation; regulation of Rac GTPase activity; regulation of cell migration; regulation of protein kinase B signaling cascade; ribosome binding IPR016024; IPR028268; IPR028267; IPR028272; Rapamycin-insensitive companion of mTOR (AVO3 homolog) (mAVO3) (Protein pianissimo) Rictor Kiaa1999 Mus musculus (Mouse) TR20154_c2_g1_i1 O77203 PIAA_DICDI 7.00E-09 GO:0031929; GO:0031932; GO:0007190; GO:0032148; GO:0031152; GO:0043327; GO:0005829; GO:0008047; GO:0030010; GO:0005085; GO:0000281; GO:0050765; GO:0051897; GO:0071902; GO:0043520 TOR signaling cascade; TORC2 complex; activation of adenylate cyclase activity; activation of protein kinase B activity; aggregation involved in sorocarp development; chemotaxis to cAMP; cytosol; enzyme activator activity; establishment of cell polarity; guanyl-nucleotide exchange factor activity; mitotic cytokinesis; negative regulation of phagocytosis; positive regulation of protein kinase B signaling cascade; positive regulation of protein serine/threonine kinase activity; regulation of myosin II filament assembly IPR016024; IPR028268; IPR028267; Protein pianissimo A (Developmental gene 1117 protein) (Protein pianissimo) (Target of rapamycin complex 2 subunit piaA) (TORC2 subunit piaA) piaA amiA DG1117 pia DDB_G0277399 Dictyostelium discoideum (Slime mold) TR20155_c0_g1_i1 P34714 SPRC_CAEEL 2.00E-46 GO:0005604; GO:0005509; GO:0005615; GO:0007275; GO:0007165 basement membrane; calcium ion binding; extracellular space; multicellular organismal development; signal transduction IPR011992; IPR018247; IPR003645; IPR015369; IPR002350; IPR001999; IPR019577; SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine) ost-1 sparc C44B12.2 Caenorhabditis elegans TR20156_c1_g1_i1 Q96JP2 MY15B_HUMAN 7.00E-19 GO:0005524; GO:0005737; GO:0003774; GO:0016459 ATP binding; cytoplasm; motor activity; myosin complex IPR000048; IPR001609; IPR000857; IPR027417; IPR011511; IPR001452; Unconventional myosin-XVB (Myosin XVBP) (Unconventional myosin-15B) MYO15B KIAA1783 MYO15BP Homo sapiens (Human) TR20157_c0_g3_i1 Q6AZW1 KISHB_DANRE 9.00E-15 GO:0000139; GO:0016021 Golgi membrane; integral to membrane IPR009653; Protein kish-B (Transmembrane protein 167B) tmem167b zgc:101127 Danio rerio (Zebrafish) (Brachydanio rerio) TR20160_c2_g1_i1 Q3UTQ8 CDKL5_MOUSE 3.00E-15 GO:0005524; GO:0004693; GO:0005737; GO:0016301; GO:0005634; GO:0046777 ATP binding; cyclin-dependent protein serine/threonine kinase activity; cytoplasm; kinase activity; nucleus; protein autophosphorylation IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase-like 5 (EC 2.7.11.22) Cdkl5 Mus musculus (Mouse) TR20165_c0_g1_i1 Q5ZHK9 LLPH_CHICK 2.00E-11 IPR018784; Protein LLP homolog (Protein LAPS18-like) LLPH RCJMB04_37b22 Gallus gallus (Chicken) TR20178_c1_g1_i1 Q5RAL3 GRM3_PONAB 1.00E-20 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR000162; IPR001234; IPR028082; Metabotropic glutamate receptor 3 (mGluR3) GRM3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR20190_c0_g2_i1 O77834 PRDX6_BOVIN 3.00E-95 GO:0016023; GO:0005829; GO:0004602; GO:0005764; GO:0004601; GO:0051920; GO:0004623; GO:0009395; GO:0000302 cytoplasmic membrane-bounded vesicle; cytosol; glutathione peroxidase activity; lysosome; peroxidase activity; peroxiredoxin activity; phospholipase A2 activity; phospholipid catabolic process; response to reactive oxygen species IPR000866; IPR024706; IPR019479; IPR012336; Peroxiredoxin-6 (EC 1.11.1.15) (1-Cys peroxiredoxin) (1-Cys PRX) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.-) (Antioxidant protein 2) (Ciliary body glutathione peroxidase) (Non-selenium glutathione peroxidase) (NSGPx) (EC 1.11.1.9) (PHGPx) PRDX6 AOP2 GPX PHGPX Bos taurus (Bovine) TR20191_c0_g1_i1 Q3TPE9 ANKY2_MOUSE 4.00E-07 GO:0005929; GO:0046872 cilium; metal ion binding IPR002110; IPR020683; IPR002893; Ankyrin repeat and MYND domain-containing protein 2 Ankmy2 Mus musculus (Mouse) TR20198_c1_g1_i1 Q7T3Y0 NARPA_DANRE 8.00E-10 GO:0007219; GO:0002043; GO:0045746; GO:0001755; GO:0001569; GO:0050931; GO:0090263; GO:0001938; GO:0022407; GO:0006355; GO:0006351 "Notch signaling pathway; blood vessel endothelial cell proliferation involved in sprouting angiogenesis; negative regulation of Notch signaling pathway; neural crest cell migration; patterning of blood vessels; pigment cell differentiation; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of endothelial cell proliferation; regulation of cell-cell adhesion; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002110; IPR020683; Notch-regulated ankyrin repeat-containing protein A nrarpa zgc:100826 Danio rerio (Zebrafish) (Brachydanio rerio) TR20198_c2_g1_i1 Q8Q0U0 Y045_METMA 2.00E-11 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR20198_c3_g1_i1 Q9ULJ7 ANR50_HUMAN 4.00E-07 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) TR2020_c0_g1_i1 Q20696 SMSR1_CAEEL 3.00E-15 GO:0016021; GO:0006686; GO:0016740 integral to membrane; sphingomyelin biosynthetic process; transferase activity IPR001660; IPR013761; IPR021129; IPR025749; Sphingomyelin synthase-related 1 (EC 2.7.8.-) F53B1.2 Caenorhabditis elegans TR20206_c0_g1_i1 O43422 P52K_HUMAN 7.00E-08 GO:0003677; GO:0046872; GO:0008285; GO:0005634; GO:0006950; GO:0007165 DNA binding; metal ion binding; negative regulation of cell proliferation; nucleus; response to stress; signal transduction IPR025398; IPR008906; IPR012337; IPR006612; 52 kDa repressor of the inhibitor of the protein kinase (p52rIPK) (58 kDa interferon-induced protein kinase-interacting protein) (p58IPK-interacting protein) (Death-associated protein 4) (THAP domain-containing protein 0) PRKRIR DAP4 P52RIPK THAP0 Homo sapiens (Human) TR20207_c0_g1_i1 P18503 CAS4_EPHMU 3.00E-06 GO:0005581 collagen IPR008160; Short-chain collagen C4 (Fragment) Ephydatia muelleri (Mueller's freshwater sponge) TR20209_c0_g1_i1 Q17QJ1 ACSF2_BOVIN 2.00E-17 GO:0005524; GO:0006631; GO:0016874; GO:0005739 ATP binding; fatty acid metabolic process; ligase activity; mitochondrion IPR025110; IPR020845; IPR000873; "Acyl-CoA synthetase family member 2, mitochondrial (EC 6.2.1.-)" ACSF2 Bos taurus (Bovine) TR20209_c0_g2_i1 B2U6V1 ACSA_RALPJ 2.00E-06 GO:0016208; GO:0005524; GO:0003987; GO:0019427; GO:0046872 AMP binding; ATP binding; acetate-CoA ligase activity; acetyl-CoA biosynthetic process from acetate; metal ion binding IPR011904; IPR025110; IPR020845; IPR000873; Acetyl-coenzyme A synthetase (AcCoA synthetase) (Acs) (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme) acsA Rpic_2099 Ralstonia pickettii (strain 12J) TR20210_c0_g1_i1 Q9UM22 EPDR1_HUMAN 5.00E-07 GO:0005509; GO:0007160; GO:0005576; GO:0005764 calcium ion binding; cell-matrix adhesion; extracellular region; lysosome IPR001299; IPR018224; Mammalian ependymin-related protein 1 (MERP-1) (Upregulated in colorectal cancer gene 1 protein) EPDR1 MERP1 UCC1 Homo sapiens (Human) TR20216_c0_g1_i1 Q3V2K1 CX065_MOUSE 1.00E-12 Uncharacterized protein CXorf65 homolog Gm614 Mus musculus (Mouse) TR20216_c0_g4_i1 Q3V2K1 CX065_MOUSE 7.00E-12 Uncharacterized protein CXorf65 homolog Gm614 Mus musculus (Mouse) TR2022_c0_g1_i1 Q66PY1 SCUB3_MOUSE 2.00E-07 GO:0005509; GO:0009986; GO:0005576; GO:0051291; GO:0051260 calcium ion binding; cell surface; extracellular region; protein heterooligomerization; protein homooligomerization IPR026823; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR011641; "Signal peptide, CUB and EGF-like domain-containing protein 3" Scube3 Mus musculus (Mouse) TR20221_c0_g1_i1 P45842 RL34_AEDAL 2.00E-42 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR008195; IPR018065; 60S ribosomal protein L34 (L31) RpL34 RpL31 Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta) TR20223_c0_g1_i1 Q3U0J8 TBD2B_MOUSE 8.00E-82 GO:0005097; GO:0005543; GO:0032851 Rab GTPase activator activity; phospholipid binding; positive regulation of Rab GTPase activity IPR011993; IPR001849; IPR000195; TBC1 domain family member 2B Tbc1d2b Kiaa1055 Mus musculus (Mouse) TR20224_c3_g1_i1 Q96DM1 PGBD4_HUMAN 2.00E-09 PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) TR20226_c0_g1_i1 Q17QU7 DHR13_BOVIN 2.00E-22 GO:0005576; GO:0016491 extracellular region; oxidoreductase activity IPR002198; IPR002347; IPR016040; Dehydrogenase/reductase SDR family member 13 (EC 1.1.-.-) DHRS13 Bos taurus (Bovine) TR20228_c0_g1_i1 P91443 HUM6_CAEEL 7.00E-43 GO:0005524; GO:0005737; GO:0003774; GO:0031476; GO:0007165 ATP binding; cytoplasm; motor activity; myosin VI complex; signal transduction IPR019749; IPR014352; IPR019748; IPR000299; IPR018979; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; Unconventional myosin heavy chain 6 hum-6 T10H10.1 Caenorhabditis elegans TR20228_c0_g2_i1 Q9V3Z6 MYO7A_DROME 2.00E-59 GO:0005524; GO:0003779; GO:0007015; GO:0030048; GO:0030898; GO:0048800; GO:0045179; GO:0008407; GO:0035293; GO:0035317; GO:0008586; GO:0005902; GO:0003774; GO:0031477; GO:0007605 ATP binding; actin binding; actin filament organization; actin filament-based movement; actin-dependent ATPase activity; antennal morphogenesis; apical cortex; chaeta morphogenesis; chitin-based larval cuticle pattern formation; imaginal disc-derived wing hair organization; imaginal disc-derived wing vein morphogenesis; microvillus; motor activity; myosin VII complex; sensory perception of sound IPR019749; IPR014352; IPR019748; IPR000299; IPR018979; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; IPR001452; Myosin-VIIa (DmVIIa) (Protein crinkled) ck CG7595 Drosophila melanogaster (Fruit fly) TR20228_c1_g1_i1 P47808 MYSH_ACACA 9.00E-07 GO:0005524; GO:0003774; GO:0016459 ATP binding; motor activity; myosin complex IPR000048; IPR001609; IPR000857; IPR027417; IPR001452; High molecular weight form of myosin-1 (High molecular weight form of myosin I) (HMWMI) Acanthamoeba castellanii (Amoeba) TR20232_c4_g1_i1 E1BPH3 TDRD5_BOVIN 4.00E-15 GO:0043046; GO:0030719; GO:0033391; GO:0071546; GO:0007286 DNA methylation involved in gamete generation; P granule organization; chromatoid body; pi-body; spermatid development IPR025605; IPR002999; Tudor domain-containing protein 5 TDRD5 Bos taurus (Bovine) TR20249_c0_g1_i1 Q23551 UNC22_CAEEL 6.00E-16 GO:0031672; GO:0005524; GO:0046872; GO:0004674 A band; ATP binding; metal ion binding; protein serine/threonine kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans TR20251_c1_g1_i1 Q54HW1 PSD10_DICDI 2.00E-07 IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) psmD10 DDB_G0289189 Dictyostelium discoideum (Slime mold) TR20252_c0_g1_i1 Q02085 SNAI1_MOUSE 2.00E-15 GO:0061314; GO:0001078; GO:0060536; GO:0016477; GO:0005737; GO:0003198; GO:0031069; GO:0060972; GO:0001707; GO:0046872; GO:0043518; GO:0060806; GO:1902230; GO:0010957; GO:0005634; GO:0001649; GO:0060021; GO:0030335; GO:0010718; GO:0045893; GO:2000810; GO:0043565; GO:0060707 P09874 "Notch signaling involved in heart development; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; cartilage morphogenesis; cell migration; cytoplasm; epithelial to mesenchymal transition involved in endocardial cushion formation; hair follicle morphogenesis; left/right pattern formation; mesoderm formation; metal ion binding; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of cell differentiation involved in embryonic placenta development; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of vitamin D biosynthetic process; nucleus; osteoblast differentiation; palate development; positive regulation of cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of transcription, DNA-dependent; regulation of tight junction assembly; sequence-specific DNA binding; trophoblast giant cell differentiation" IPR007087; IPR015880; IPR013087; Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna) Snai1 Sna Mus musculus (Mouse) TR20252_c1_g1_i1 Q9H7R5 ZN665_HUMAN 1.00E-57 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 665 (Zinc finger protein 160-like) ZNF665 ZFP160L Homo sapiens (Human) TR20252_c1_g1_i2 A6NGD5 ZSA5C_HUMAN 1.00E-25 GO:0046872; GO:0003676; GO:0005634; GO:0000981 metal ion binding; nucleic acid binding; nucleus; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 5C ZSCAN5C Homo sapiens (Human) TR20256_c0_g1_i1 Q76LX8 ATS13_HUMAN 2.00E-06 GO:0005509; GO:0009986; GO:0007160; GO:0005615; GO:0009100; GO:0005178; GO:0007229; GO:0004222; GO:0008237; GO:0043171; GO:0030168; GO:0016485; GO:0005578; GO:0006508; GO:0008270 P04275 calcium ion binding; cell surface; cell-matrix adhesion; extracellular space; glycoprotein metabolic process; integrin binding; integrin-mediated signaling pathway; metalloendopeptidase activity; metallopeptidase activity; peptide catabolic process; platelet activation; protein processing; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000859; IPR024079; IPR001590; IPR013273; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAM-TS 13) (ADAM-TS13) (ADAMTS-13) (EC 3.4.24.87) (von Willebrand factor-cleaving protease) (vWF-CP) (vWF-cleaving protease) ADAMTS13 C9orf8 UNQ6102/PRO20085 Homo sapiens (Human) TR20257_c0_g1_i1 Q6R7D0 IAP3_OSHVF 3.00E-09 IPR001370; Putative apoptosis inhibitor ORF99 ORF99 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) TR20257_c2_g2_i1 A1E2V0 BIRC3_CANFA 4.00E-25 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) BIRC3 Canis familiaris (Dog) (Canis lupus familiaris) TR20257_c2_g3_i1 Q13490 BIRC2_HUMAN 6.00E-26 GO:0035631; GO:0038061; GO:0035666; GO:0007166; GO:0006921; GO:0005829; GO:0045087; GO:0009898; GO:0070266; GO:0043066; GO:0005634; GO:0001890; GO:0043123; GO:0043161; GO:0000209; GO:0039535; GO:0051726; GO:0045595; GO:0042127; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0006355; GO:0034138; GO:0034142; GO:0003713; GO:0006351; GO:0004842; GO:0008270 P55210; Q9NR28; P63000; Q13546; O43353; Q9Y572; P57078; Q9NP84; Q12933 "CD40 receptor complex; NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; cell surface receptor signaling pathway; cellular component disassembly involved in execution phase of apoptosis; cytosol; innate immune response; internal side of plasma membrane; necroptosis; negative regulation of apoptotic process; nucleus; placenta development; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of RIG-I signaling pathway; regulation of cell cycle; regulation of cell differentiation; regulation of cell proliferation; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; regulation of transcription, DNA-dependent; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (IAP-2) (hIAP-2) (hIAP2) (RING finger protein 48) (TNFR2-TRAF-signaling complex protein 2) BIRC2 API1 IAP2 MIHB RNF48 Homo sapiens (Human) TR20258_c0_g1_i1 O43426 SYNJ1_HUMAN 1.00E-112 GO:0003723; GO:0005829; GO:0043647; GO:0004445; GO:0000166; GO:0006661; GO:0046856; GO:0004439; GO:0048488 "RNA binding; cytosol; inositol phosphate metabolic process; inositol-polyphosphate 5-phosphatase activity; nucleotide binding; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; synaptic vesicle endocytosis" IPR015047; IPR005135; IPR000300; IPR012677; IPR000504; IPR002013; "Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)" SYNJ1 KIAA0910 Homo sapiens (Human) TR20258_c3_g2_i1 P50942 INP52_YEAST 3.00E-07 GO:0030479; GO:0006897; GO:0046856; GO:0043813; GO:0004438; GO:0004439; GO:0043812; GO:0015031 P15891; Q06604; P32790 "actin cortical patch; endocytosis; phosphatidylinositol dephosphorylation; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; phosphatidylinositol-3-phosphatase activity; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; phosphatidylinositol-4-phosphate phosphatase activity; protein transport" IPR005135; IPR000300; IPR002013; "Polyphosphatidylinositol phosphatase INP52 (Synaptojanin-like protein 2) [Includes: SAC1-like phosphoinositide phosphatase (EC 3.1.3.-); Phosphatidylinositol 4,5-bisphosphate 5-phosphatase (EC 3.1.3.36)]" INP52 SJL2 YNL106C N2160 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR20258_c3_g3_i1 O43426 SYNJ1_HUMAN 2.00E-44 GO:0003723; GO:0005829; GO:0043647; GO:0004445; GO:0000166; GO:0006661; GO:0046856; GO:0004439; GO:0048488 "RNA binding; cytosol; inositol phosphate metabolic process; inositol-polyphosphate 5-phosphatase activity; nucleotide binding; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; synaptic vesicle endocytosis" IPR015047; IPR005135; IPR000300; IPR012677; IPR000504; IPR002013; "Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)" SYNJ1 KIAA0910 Homo sapiens (Human) TR20261_c1_g1_i1 Q0VCA5 SAMH1_BOVIN 3.00E-68 GO:0003723; GO:0051607; GO:0045087; GO:0008152; GO:0046872; GO:0005634; GO:0008081; GO:0045088 RNA binding; defense response to virus; innate immune response; metabolic process; metal ion binding; nucleus; phosphoric diester hydrolase activity; regulation of innate immune response IPR003607; IPR006674; IPR013761; Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) SAMHD1 Bos taurus (Bovine) TR20265_c0_g1_i1 Q6GPV5 RN181_XENLA 4.00E-45 GO:0016874; GO:0016567; GO:0008270 ligase activity; protein ubiquitination; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF181 (EC 6.3.2.-) (RING finger protein 181) rnf181 Xenopus laevis (African clawed frog) TR20277_c1_g1_i1 Q9AJD6 PNO_MICLT 1.00E-07 GO:0006066; GO:0008812; GO:0050660; GO:0050237; GO:0042820 alcohol metabolic process; choline dehydrogenase activity; flavin adenine dinucleotide binding; pyridoxine 4-oxidase activity; vitamin B6 catabolic process IPR012132; IPR000172; IPR007867; Cofactor degradation; B6 vitamer degradation; pyridoxal from pyridoxine (oxidase route): step 1/1. Pyridoxine 4-oxidase (EC 1.1.3.12) pno Microbacterium luteolum (Aureobacterium luteolum) TR20280_c0_g2_i1 Q6GM59 MOT12_XENLA 2.00E-23 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 Xenopus laevis (African clawed frog) TR20301_c0_g1_i1 O96567 DDC_DROSI 8.00E-38 GO:0004058; GO:0042423; GO:0006520; GO:0030170 aromatic-L-amino-acid decarboxylase activity; catecholamine biosynthetic process; cellular amino acid metabolic process; pyridoxal phosphate binding IPR010977; IPR002129; IPR015424; IPR015421; IPR015422; IPR021115; Aromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC) Ddc Drosophila simulans (Fruit fly) TR20301_c1_g1_i1 P20711 DDC_HUMAN 4.00E-114 GO:0016597; GO:0004058; GO:0030424; GO:0042423; GO:0006520; GO:0071312; GO:0035690; GO:0071363; GO:0007623; GO:0005829; GO:0042416; GO:0046219; GO:0033076; GO:0010259; GO:0043025; GO:0052314; GO:0030170; GO:0046684; GO:0042427; GO:0044281; GO:0008021; GO:0015842 P10275 amino acid binding; aromatic-L-amino-acid decarboxylase activity; axon; catecholamine biosynthetic process; cellular amino acid metabolic process; cellular response to alkaloid; cellular response to drug; cellular response to growth factor stimulus; circadian rhythm; cytosol; dopamine biosynthetic process; indolalkylamine biosynthetic process; isoquinoline alkaloid metabolic process; multicellular organismal aging; neuronal cell body; phytoalexin metabolic process; pyridoxal phosphate binding; response to pyrethroid; serotonin biosynthetic process; small molecule metabolic process; synaptic vesicle; synaptic vesicle amine transport IPR010977; IPR002129; IPR015424; IPR015421; IPR015422; IPR021115; Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2. Aromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC) DDC AADC Homo sapiens (Human) TR20302_c0_g1_i1 Q08462 ADCY2_HUMAN 3.00E-14 GO:0005524; GO:0007202; GO:0034199; GO:0004016; GO:0008179; GO:0007189; GO:0007193; GO:0008294; GO:0071377; GO:0005737; GO:0030425; GO:0006112; GO:0007173; GO:0008543; GO:0045087; GO:0016021; GO:0035556; GO:0045121; GO:0046872; GO:0048011; GO:0005886; GO:0043234; GO:0046982; GO:0007268; GO:0055085; GO:0006833 ATP binding; activation of phospholipase C activity; activation of protein kinase A activity; adenylate cyclase activity; adenylate cyclase binding; adenylate cyclase-activating G-protein coupled receptor signaling pathway; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; calcium- and calmodulin-responsive adenylate cyclase activity; cellular response to glucagon stimulus; cytoplasm; dendrite; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; integral to membrane; intracellular signal transduction; membrane raft; metal ion binding; neurotrophin TRK receptor signaling pathway; plasma membrane; protein complex; protein heterodimerization activity; synaptic transmission; transmembrane transport; water transport IPR001054; IPR018297; IPR009398; Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2) ADCY2 KIAA1060 Homo sapiens (Human) TR20304_c1_g1_i1 Q2PZL6 FAT4_MOUSE 6.00E-38 GO:0045177; GO:0001658; GO:0005509; GO:0048565; GO:0001736; GO:0003007; GO:0007156; GO:0060122; GO:0016021; GO:0001822; GO:0043931; GO:0005886; GO:0007009 apical part of cell; branching involved in ureteric bud morphogenesis; calcium ion binding; digestive tract development; establishment of planar polarity; heart morphogenesis; homophilic cell adhesion; inner ear receptor stereocilium organization; integral to membrane; kidney development; ossification involved in bone maturation; plasma membrane; plasma membrane organization IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) Fat4 Fatj Mus musculus (Mouse) TR20304_c1_g2_i1 Q9H251 CAD23_HUMAN 3.00E-28 GO:0005509; GO:0006816; GO:0016339; GO:0051480; GO:0050957; GO:0007156; GO:0016021; GO:0016020; GO:0045494; GO:0005886; GO:0050896; GO:0050953; GO:0007605; GO:0032420; GO:0007601 calcium ion binding; calcium ion transport; calcium-dependent cell-cell adhesion; cytosolic calcium ion homeostasis; equilibrioception; homophilic cell adhesion; integral to membrane; membrane; photoreceptor cell maintenance; plasma membrane; response to stimulus; sensory perception of light stimulus; sensory perception of sound; stereocilium; visual perception IPR002126; IPR015919; IPR020894; Cadherin-23 (Otocadherin) CDH23 KIAA1774 KIAA1812 UNQ1894/PRO4340 Homo sapiens (Human) TR20305_c3_g1_i1 O08625 SYT10_RAT 3.00E-15 GO:0030054; GO:0016021; GO:0046872; GO:0050803; GO:0030672; GO:0005215 cell junction; integral to membrane; metal ion binding; regulation of synapse structure and activity; synaptic vesicle membrane; transporter activity IPR000008; IPR001565; Synaptotagmin-10 (Synaptotagmin X) (SytX) Syt10 Rattus norvegicus (Rat) TR20305_c4_g1_i1 Q9BQG1 SYT3_HUMAN 4.00E-13 GO:0005544; GO:0030054; GO:0005768; GO:0016021; GO:0046872; GO:0030672; GO:0005215 calcium-dependent phospholipid binding; cell junction; endosome; integral to membrane; metal ion binding; synaptic vesicle membrane; transporter activity IPR000008; IPR001565; Synaptotagmin-3 (Synaptotagmin III) (SytIII) SYT3 Homo sapiens (Human) TR20315_c0_g1_i1 Q4G1G8 CH25H_PIG 8.00E-15 GO:0001567; GO:0005789; GO:0006633; GO:0016021; GO:0005506; GO:0016126 cholesterol 25-hydroxylase activity; endoplasmic reticulum membrane; fatty acid biosynthetic process; integral to membrane; iron ion binding; sterol biosynthetic process IPR006694; Cholesterol 25-hydroxylase (EC 1.14.99.38) (Cholesterol 25-monooxygenase) CH25H Sus scrofa (Pig) TR20318_c0_g1_i1 Q7ZU45 TTC25_DANRE 1.00E-34 IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 25 (TPR repeat protein 25) ttc25 Danio rerio (Zebrafish) (Brachydanio rerio) TR20319_c0_g1_i1 Q9I929 FUCL3_ANGJA 8.00E-06 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-3 Anguilla japonica (Japanese eel) TR2032_c0_g1_i1 Q9J504 V231_FOWPN 4.00E-11 IPR002110; IPR020683; Putative ankyrin repeat protein FPV231 FPV231 Fowlpox virus (strain NVSL) (FPV) TR20332_c0_g3_i1 Q62910 SYNJ1_RAT 3.00E-53 GO:0003723; GO:0017124; GO:0007420; GO:0005737; GO:0006897; GO:0043005; GO:0000166; GO:0046856; GO:0034595; GO:0004439; GO:0014015; GO:0048260; GO:0043234; GO:0032403; GO:0034097; GO:0032526 Q12965; Q99962; O35179; O35180 "RNA binding; SH3 domain binding; brain development; cytoplasm; endocytosis; neuron projection; nucleotide binding; phosphatidylinositol dephosphorylation; phosphatidylinositol phosphate 5-phosphatase activity; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; positive regulation of gliogenesis; positive regulation of receptor-mediated endocytosis; protein complex; protein complex binding; response to cytokine stimulus; response to retinoic acid" IPR015047; IPR005135; IPR000300; IPR012677; IPR000504; IPR002013; "Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)" Synj1 Rattus norvegicus (Rat) TR20332_c1_g1_i1 O43001 SYJ1_SCHPO 8.00E-16 GO:0032153; GO:0051286; GO:0005829; GO:0006897; GO:0048017; GO:0004445; GO:0046856; GO:0004439; GO:0015031 "cell division site; cell tip; cytosol; endocytosis; inositol lipid-mediated signaling; inositol-polyphosphate 5-phosphatase activity; phosphatidylinositol dephosphorylation; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; protein transport" IPR005135; IPR000300; IPR002013; "Inositol-1,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.36) (Synaptojanin-like protein 1)" syj1 SPBC2G2.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR20335_c0_g1_i1 Q93RV9 ECTD_STRCO 3.00E-12 GO:0016725 "oxidoreductase activity, acting on CH or CH2 groups" IPR012774; IPR008775; Ectoine hydroxylase (EC 1.17.-.-) ectD SCO1867 SCI39.14 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) TR20337_c0_g1_i1 Q8N539 FBCD1_HUMAN 6.00E-12 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 UNQ701/PRO1346 Homo sapiens (Human) TR20341_c0_g1_i1 O14815 CAN9_HUMAN 2.00E-14 GO:0005509; GO:0004198; GO:0007586; GO:0005622; GO:0006508 calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; digestion; intracellular; proteolysis IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-9 (EC 3.4.22.-) (Digestive tract-specific calpain) (New calpain 4) (nCL-4) (Protein CG36) CAPN9 NCL4 Homo sapiens (Human) TR20341_c0_g2_i1 Q92177 CAN3_CHICK 3.00E-14 GO:0030315; GO:0030018; GO:0005509; GO:0004198; GO:0071277; GO:0071472; GO:0005829; GO:0055103; GO:0043066; GO:0033234; GO:0045892; GO:0005634; GO:0051092; GO:0045862; GO:0051281; GO:0014718; GO:0045893; GO:0043234; GO:0006461; GO:0032947; GO:0072657; GO:0043122; GO:0014850; GO:0045214; GO:0097264; GO:0031402; GO:0008307; GO:0031432 "T-tubule; Z disc; calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cellular response to calcium ion; cellular response to salt stress; cytosol; ligase regulator activity; negative regulation of apoptotic process; negative regulation of protein sumoylation; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of proteolysis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of satellite cell activation involved in skeletal muscle regeneration; positive regulation of transcription, DNA-dependent; protein complex; protein complex assembly; protein complex scaffold; protein localization to membrane; regulation of I-kappaB kinase/NF-kappaB cascade; response to muscle activity; sarcomere organization; self proteolysis; sodium ion binding; structural constituent of muscle; titin binding" IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) CAPN3 Gallus gallus (Chicken) TR20347_c0_g2_i1 P00130 QCR9_BOVIN 3.00E-18 GO:0006122; GO:0005750 "mitochondrial electron transport, ubiquinol to cytochrome c; mitochondrial respiratory chain complex III" IPR008027; Cytochrome b-c1 complex subunit 9 (Complex III subunit 9) (Complex III subunit X) (Cytochrome c1 non-heme 7 kDa protein) (Ubiquinol-cytochrome c reductase complex 7.2 kDa protein) UQCR10 Bos taurus (Bovine) TR20351_c0_g1_i1 P07872 ACOX1_RAT 2.00E-39 GO:0003995; GO:0033540; GO:0005504; GO:0050660; GO:0006091; GO:0016401; GO:0005777; GO:0006693 acyl-CoA dehydrogenase activity; fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid binding; flavin adenine dinucleotide binding; generation of precursor metabolites and energy; palmitoyl-CoA oxidase activity; peroxisome; prostaglandin metabolic process IPR006091; IPR012258; IPR002655; IPR009075; IPR013786; IPR009100; Lipid metabolism; peroxisomal fatty acid beta-oxidation. "Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain]" Acox1 Acox Rattus norvegicus (Rat) TR20360_c1_g1_i1 P54612 2AAA_PIG 1.00E-50 GO:0003823; GO:0007059; GO:0000775; GO:0005829; GO:0070262; GO:0000159; GO:0004722; GO:0042981 "antigen binding; chromosome segregation; chromosome, centromeric region; cytosol; peptidyl-serine dephosphorylation; protein phosphatase type 2A complex; protein serine/threonine phosphatase activity; regulation of apoptotic process" IPR011989; IPR016024; IPR000357; IPR021133; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) PPP2R1A Sus scrofa (Pig) TR20369_c1_g1_i1 Q3U095 NXPE2_MOUSE 2.00E-06 GO:0016021 integral to membrane IPR013783; IPR014756; IPR026845; NXPE family member 2 (Protein FAM55B) Nxpe2 Fam55b Mus musculus (Mouse) TR20370_c0_g1_i1 P97278 ITIH1_MESAU 1.00E-23 GO:0005576; GO:0030212; GO:0004867 extracellular region; hyaluronan metabolic process; serine-type endopeptidase inhibitor activity IPR010600; IPR013694; IPR002035; Inter-alpha-trypsin inhibitor heavy chain H1 (ITI heavy chain H1) (ITI-HC1) (Inter-alpha-inhibitor heavy chain 1) ITIH1 Mesocricetus auratus (Golden hamster) TR20370_c0_g2_i1 P97280 ITIH3_MESAU 2.00E-22 GO:0005576; GO:0030212; GO:0004867 extracellular region; hyaluronan metabolic process; serine-type endopeptidase inhibitor activity IPR010600; IPR013694; IPR002035; Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) ITIH3 Mesocricetus auratus (Golden hamster) TR20370_c1_g1_i1 Q86UX2 ITIH5_HUMAN 1.00E-23 GO:0005576; GO:0030212; GO:0004867 extracellular region; hyaluronan metabolic process; serine-type endopeptidase inhibitor activity IPR010600; IPR013694; IPR002035; Inter-alpha-trypsin inhibitor heavy chain H5 (ITI heavy chain H5) (ITI-HC5) (Inter-alpha-inhibitor heavy chain 5) ITIH5 KIAA1953 PP14776 UNQ311/PRO354 Homo sapiens (Human) TR20373_c0_g2_i1 O13067 CND2_XENLA 8.00E-17 GO:0051301; GO:0005694; GO:0030261; GO:0005829; GO:0007067; GO:0005634 cell division; chromosome; chromosome condensation; cytosol; mitosis; nucleus IPR022816; Condensin complex subunit 2 (Barren homolog) (Chromosome assembly protein xCAP-H) (Chromosome-associated protein H) (Non-SMC condensin I complex subunit H) ncaph brrn1 caph Xenopus laevis (African clawed frog) TR20374_c0_g2_i1 Q9TSV3 CCHCR_PIG 2.00E-10 GO:0030154; GO:0005814; GO:0007275; GO:0005634; GO:0006611 cell differentiation; centriole; multicellular organismal development; nucleus; protein export from nucleus IPR009800; Coiled-coil alpha-helical rod protein 1 (Alpha-helical coiled-coil rod protein) (Fragment) CCHCR1 HCR Sus scrofa (Pig) TR20374_c7_g1_i1 Q8HZ58 CCHCR_PONPY 2.00E-14 GO:0030154; GO:0005814; GO:0007275; GO:0005634 cell differentiation; centriole; multicellular organismal development; nucleus IPR009800; Coiled-coil alpha-helical rod protein 1 (Alpha-helical coiled-coil rod protein) CCHCR1 HCR Pongo pygmaeus (Bornean orangutan) TR20378_c0_g1_i1 Q01484 ANK2_HUMAN 2.00E-13 GO:0051117; GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0007411; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005829; GO:0005887; GO:0014704; GO:0044325; GO:0086046; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307; GO:0070296 P11532-5; P62993 "ATPase binding; M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; axon guidance; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; cytosol; integral to plasma membrane; intercalated disc; ion channel binding; membrane depolarization involved in regulation of SA node cell action potential; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization; sarcoplasmic reticulum calcium ion transport" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) TR20378_c1_g1_i1 P81069 GABP2_MOUSE 1.00E-07 GO:0005634; GO:0045944; GO:0046982; GO:0042803; GO:0044212; GO:0006351 "nucleus; positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; protein homodimerization activity; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR002110; IPR020683; GA-binding protein subunit beta-2 (GABP subunit beta-2) (GABPB-2) (GA-binding protein beta-2-1) (GABP subunit beta-2-1) (GABPB2-1) Gabpb2 Mus musculus (Mouse) TR20394_c0_g1_i1 Q4GXG7 RL18_TIMBA 1.00E-97 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000039; IPR021131; IPR021132; 60S ribosomal protein L18 RpL18 Timarcha balearica TR20398_c1_g1_i1 Q6NZL6 TONSL_MOUSE 2.00E-07 GO:0005737; GO:0000724; GO:0042393; GO:0043596; GO:0031297 cytoplasm; double-strand break repair via homologous recombination; histone binding; nuclear replication fork; replication fork processing IPR002110; IPR020683; IPR013026; IPR011990; IPR019734; Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2) Tonsl Ikbr Nfkbil2 Mus musculus (Mouse) TR20398_c2_g1_i1 Q10311 YD58_SCHPO 2.00E-17 GO:0005829; GO:0005634; GO:0043161; GO:0005838 cytosol; nucleus; proteasomal ubiquitin-dependent protein catabolic process; proteasome regulatory particle IPR002110; IPR020683; Ankyrin repeat-containing protein C6C3.08 SPAC6C3.08 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR20400_c0_g2_i1 Q9EPR5 SORC2_MOUSE 1.00E-11 GO:0016021 integral to membrane IPR022409; IPR000601; IPR006581; VPS10 domain-containing receptor SorCS2 Sorcs2 Mus musculus (Mouse) TR20405_c1_g1_i1 P04569 SCP1_BRALA 8.00E-19 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; "Sarcoplasmic calcium-binding proteins I, III, and IV (SCP I, III, IV)" Branchiostoma lanceolatum (Common lancelet) (Amphioxus) TR20406_c1_g1_i1 Q9NUV9 GIMA4_HUMAN 1.00E-24 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR20408_c1_g1_i1 O08900 IKZF3_MOUSE 1.00E-10 GO:0042113; GO:0005737; GO:0046872; GO:0005634; GO:0005886; GO:0042803; GO:0045577; GO:0030888; GO:0042981; GO:0006355; GO:0043565; GO:0006351 "B cell activation; cytoplasm; metal ion binding; nucleus; plasma membrane; protein homodimerization activity; regulation of B cell differentiation; regulation of B cell proliferation; regulation of apoptotic process; regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein Aiolos (Ikaros family zinc finger protein 3) Ikzf3 Zfpn1a3 Znfn1a3 Mus musculus (Mouse) TR20420_c2_g1_i1 Q8BZZ3 WWP1_MOUSE 1.00E-11 GO:0030217; GO:0005737; GO:0030324; GO:0045892; GO:0005634; GO:0005886; GO:0043161; GO:0042787; GO:0004842 "T cell differentiation; cytoplasm; lung development; negative regulation of transcription, DNA-dependent; nucleus; plasma membrane; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity" IPR000008; IPR024928; IPR000569; IPR001202; Protein modification; protein ubiquitination. NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain-containing protein 1) Wwp1 Mus musculus (Mouse) TR20420_c2_g1_i2 Q9DBH0 WWP2_MOUSE 1.00E-10 GO:0005737; GO:0051224; GO:0043433; GO:0000122; GO:0032410; GO:0005634; GO:0043161; GO:0070534; GO:0042787; GO:0042391; GO:1901016; GO:0004842 cytoplasm; negative regulation of protein transport; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transporter activity; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein K63-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of membrane potential; regulation of potassium ion transmembrane transporter activity; ubiquitin-protein ligase activity IPR000008; IPR024928; IPR000569; IPR001202; Protein modification; protein ubiquitination. NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain-containing protein 2) Wwp2 Mus musculus (Mouse) TR20425_c0_g1_i1 P42858 HD_HUMAN 1.00E-29 GO:0006888; GO:0005794; GO:0007030; GO:0051938; GO:0009952; GO:0005776; GO:0030424; GO:0008088; GO:0048487; GO:0007569; GO:0000052; GO:0030659; GO:0005829; GO:0030425; GO:0008340; GO:0050809; GO:0007212; GO:0045505; GO:0005783; GO:0007029; GO:0016197; GO:0000132; GO:0042445; GO:0016234; GO:0030073; GO:0055072; GO:0019244; GO:0005770; GO:0007626; GO:2001237; GO:0043524; GO:0021990; GO:0051402; GO:0048666; GO:0005634; GO:0021988; GO:0048513; GO:0048341; GO:0043234; GO:0006606; GO:0019805; GO:0046902; GO:0051881; GO:0046825; GO:0034047; GO:0048167; GO:0051592; GO:0006890; GO:0035176; GO:0007283; GO:0021756; GO:0008134; GO:0000050; GO:0047496; GO:0008542 Itself; Q12873; Q14194; Q13011; Q2NKX8; Q9UI08-2; Q99689; P02792; Q9Y2X7; Q9H4A5; Q9UBP5; O00291; P68431; Q9NP66; O95163; Q9P2H0; Q8N7X4; Q9UIS9; Q9Y3C7; Q96HT8; O43312; Q14596; O00746; Q13177; P35080; Q8N2W9; O75400; P36578; Q99963; P37840; O14776; P04637; Q8IZQ1; Q8WTP9; P12956; Q8IUH5; G3V1X1; Q96NC0 "ER to Golgi vesicle-mediated transport; Golgi apparatus; Golgi organization; L-glutamate import; anterior/posterior pattern specification; autophagic vacuole; axon; axon cargo transport; beta-tubulin binding; cell aging; citrulline metabolic process; cytoplasmic vesicle membrane; cytosol; dendrite; determination of adult lifespan; diazepam binding; dopamine receptor signaling pathway; dynein intermediate chain binding; endoplasmic reticulum; endoplasmic reticulum organization; endosomal transport; establishment of mitotic spindle orientation; hormone metabolic process; inclusion body; insulin secretion; iron ion homeostasis; lactate biosynthetic process from pyruvate; late endosome; locomotory behavior; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of neuron apoptotic process; neural plate formation; neuron apoptotic process; neuron development; nucleus; olfactory lobe development; organ development; paraxial mesoderm formation; protein complex; protein import into nucleus; quinolinate biosynthetic process; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; regulation of protein export from nucleus; regulation of protein phosphatase type 2A activity; regulation of synaptic plasticity; response to calcium ion; retrograde vesicle-mediated transport, Golgi to ER; social behavior; spermatogenesis; striatum development; transcription factor binding; urea cycle; vesicle transport along microtubule; visual learning" IPR011989; IPR016024; IPR000091; IPR024613; Huntingtin (Huntington disease protein) (HD protein) HTT HD IT15 Homo sapiens (Human) TR20429_c1_g1_i2 Q03168 ASPP_AEDAE 5.00E-85 GO:0004190; GO:0005764; GO:0006508 aspartic-type endopeptidase activity; lysosome; proteolysis IPR001461; IPR001969; IPR012848; IPR021109; Lysosomal aspartic protease (EC 3.4.23.-) AAEL006169 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR20429_c3_g1_i1 O76856 CATD_DICDI 2.00E-64 GO:0004190; GO:0005576; GO:0005764; GO:0006508 aspartic-type endopeptidase activity; extracellular region; lysosome; proteolysis IPR001461; IPR001969; IPR021109; Cathepsin D (EC 3.4.23.5) (Ddp44) ctsD CatD DDB_G0279411 Dictyostelium discoideum (Slime mold) TR2043_c0_g2_i1 P83425 HIP_MYTED 4.00E-14 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR20431_c0_g1_i1 E9QAU8 RN165_MOUSE 8.00E-36 GO:0008270 zinc ion binding IPR001841; IPR013083; RING finger protein 165 Rnf165 Gm96 Mus musculus (Mouse) TR20432_c0_g1_i1 Q9UF02 CCG5_HUMAN 5.00E-26 GO:0032281; GO:0030054; GO:0014069; GO:0045211; GO:2000311; GO:0005245 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; cell junction; postsynaptic density; postsynaptic membrane; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; voltage-gated calcium channel activity IPR004031; IPR008369; IPR008368; Voltage-dependent calcium channel gamma-5 subunit (Neuronal voltage-gated calcium channel gamma-5 subunit) (Transmembrane AMPAR regulatory protein gamma-5) (TARP gamma-5) CACNG5 Homo sapiens (Human) TR20438_c0_g1_i1 P07439 LEC3_MEGRO 2.00E-10 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Lectin BRA-3 Megabalanus rosa (Acorn barnacle) TR20440_c1_g2_i2 P23978 SC6A1_RAT 1.00E-29 GO:0030424; GO:0009986; GO:0051939; GO:0005332; GO:0005887; GO:0007612; GO:0032229; GO:0043005; GO:0005328; GO:0005886; GO:0014054; GO:0051260; GO:0051592; GO:0042220; GO:0032355; GO:0010288; GO:0014074; GO:0009744; GO:0009636 "axon; cell surface; gamma-aminobutyric acid import; gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; learning; negative regulation of synaptic transmission, GABAergic; neuron projection; neurotransmitter:sodium symporter activity; plasma membrane; positive regulation of gamma-aminobutyric acid secretion; protein homooligomerization; response to calcium ion; response to cocaine; response to estradiol stimulus; response to lead ion; response to purine-containing compound; response to sucrose stimulus; response to toxic substance" IPR000175; IPR002980; Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) Slc6a1 Gabt1 Gat-1 Gat1 Rattus norvegicus (Rat) TR20441_c0_g1_i1 Q8BG19 TMTC4_MOUSE 3.00E-24 GO:0016021 integral to membrane IPR013618; IPR013026; IPR011990; IPR019734; Transmembrane and TPR repeat-containing protein 4 Tmtc4 Mus musculus (Mouse) TR20441_c1_g1_i1 Q5T4D3 TMTC4_HUMAN 3.00E-23 GO:0016021 integral to membrane IPR013618; IPR013026; IPR011990; IPR019734; Transmembrane and TPR repeat-containing protein 4 TMTC4 Homo sapiens (Human) TR20442_c0_g1_i1 A2CEI6 PIWL2_DANRE 5.00E-14 GO:0043046; GO:0000966; GO:0031047; GO:0030718; GO:0007126; GO:0007275; GO:0010991; GO:0005634; GO:0048477; GO:0071546; GO:0034584; GO:0034587; GO:0010628; GO:0006417 Q58EK5 DNA methylation involved in gamete generation; RNA 5'-end processing; gene silencing by RNA; germ-line stem cell maintenance; meiosis; multicellular organismal development; negative regulation of SMAD protein complex assembly; nucleus; oogenesis; pi-body; piRNA binding; piRNA metabolic process; positive regulation of gene expression; regulation of translation IPR003100; IPR003165; IPR012337; Piwi-like protein 2 piwil2 zili si:dkey-88f5.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR20455_c0_g1_i1 Q86SZ2 TPC6B_HUMAN 1.00E-38 GO:0005794; GO:0005783; GO:0016192 O43617 Golgi apparatus; endoplasmic reticulum; vesicle-mediated transport IPR024096; IPR007194; Trafficking protein particle complex subunit 6B TRAPPC6B Homo sapiens (Human) TR20457_c3_g1_i1 Q8TDY2 RBCC1_HUMAN 2.00E-40 GO:0007254; GO:0070969; GO:0000045; GO:0007049; GO:0005829; GO:0007507; GO:0001889; GO:0043066; GO:0005634; GO:0045793; GO:0001934; GO:0034045; GO:0010506; GO:0006355; GO:0006351 O75143; Q676U5; A7MCY6; O75385 "JNK cascade; ULK1-ATG13-FIP200 complex; autophagic vacuole assembly; cell cycle; cytosol; heart development; liver development; negative regulation of apoptotic process; nucleus; positive regulation of cell size; positive regulation of protein phosphorylation; pre-autophagosomal structure membrane; regulation of autophagy; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019460; RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) RB1CC1 KIAA0203 RBICC Homo sapiens (Human) TR20462_c0_g1_i1 P11372 CP2CF_RABIT 6.00E-15 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 2C15 (EC 1.14.14.1) (CYPIIC15) (Cytochrome P450 B32-3) (Fragment) CYP2C15 Oryctolagus cuniculus (Rabbit) TR20462_c1_g1_i1 P24470 CP2CN_RAT 1.00E-27 GO:0008392; GO:0019369; GO:0070330; GO:0005789; GO:0020037; GO:0043231; GO:0005506; GO:0033574 arachidonic acid epoxygenase activity; arachidonic acid metabolic process; aromatase activity; endoplasmic reticulum membrane; heme binding; intracellular membrane-bounded organelle; iron ion binding; response to testosterone stimulus IPR001128; IPR017972; IPR002401; Cytochrome P450 2C23 (EC 1.14.14.1) (Arachidonic acid epoxygenase) (CYPIIC23) Cyp2c23 Cyp2c-23 Rattus norvegicus (Rat) TR20462_c2_g1_i1 P12939 CP2DA_RAT 1.00E-19 GO:0070330; GO:0005789; GO:0020037; GO:0005506; GO:0004497 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity IPR001128; IPR017972; IPR002401; IPR008069; Cytochrome P450 2D10 (EC 1.14.14.1) (CYPIID10) (Cytochrome P450-CMF1B) (Cytochrome P450-DB5) (Debrisoquine 4-hydroxylase) Cyp2d10 Cyp2d-10 Cyp2d5 Rattus norvegicus (Rat) TR20469_c2_g2_i1 Q4R5T4 RNF32_MACFA 8.00E-61 GO:0005737; GO:0008270 cytoplasm; zinc ion binding IPR000048; IPR001841; IPR013083; RING finger protein 32 RNF32 QtsA-17885 QtsA-21017 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR2047_c0_g1_i1 Q9W6X3 CH10_ORYLA 2.00E-21 GO:0005524; GO:0005759; GO:0006457 ATP binding; mitochondrial matrix; protein folding IPR020818; IPR018369; IPR011032; "10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10)" hspe1 hsp10 Oryzias latipes (Medaka fish) (Japanese ricefish) TR20481_c0_g2_i1 O94812 BAIP3_HUMAN 4.00E-32 GO:0007186; GO:0007269; GO:0008022 G-protein coupled receptor signaling pathway; neurotransmitter secretion; protein C-terminus binding IPR000008; IPR014770; IPR014772; IPR019558; BAI1-associated protein 3 (BAP3) BAIAP3 KIAA0734 Homo sapiens (Human) TR20481_c2_g1_i1 Q9R189 UN13D_RAT 2.00E-11 GO:0006887; GO:0005770; GO:0005764; GO:0016020; GO:0055037; GO:0046903 exocytosis; late endosome; lysosome; membrane; recycling endosome; secretion IPR000008; IPR014770; IPR014772; IPR019558; Protein unc-13 homolog D (Munc13-4) Unc13d Unc13h4 Rattus norvegicus (Rat) TR20486_c0_g1_i1 Q5UR67 YR617_MIMIV 2.00E-19 IPR012816; Uncharacterized protein R617 MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) TR20488_c0_g1_i1 Q8MJC3 CASP3_RABIT 2.00E-12 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Oryctolagus cuniculus (Rabbit) TR20488_c1_g1_i1 Q9XYF4 ICENC_DROME 2.00E-07 GO:0006919; GO:0007417; GO:0048749; GO:0004197; GO:0005737; GO:0048813; GO:0008340; GO:0035234; GO:0008258; GO:0007516; GO:0035081; GO:0008285; GO:0016322; GO:0045476; GO:0046672; GO:0016540; GO:0042803; GO:0006508; GO:0035071; GO:0007291; GO:0031638 O01382; Q24306 activation of cysteine-type endopeptidase activity involved in apoptotic process; central nervous system development; compound eye development; cysteine-type endopeptidase activity; cytoplasm; dendrite morphogenesis; determination of adult lifespan; germ cell programmed cell death; head involution; hemocyte development; induction of programmed cell death by hormones; negative regulation of cell proliferation; neuron remodeling; nurse cell apoptotic process; positive regulation of compound eye retinal cell programmed cell death; protein autoprocessing; protein homodimerization activity; proteolysis; salivary gland cell autophagic cell death; sperm individualization; zymogen activation IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase Nc (EC 3.4.22.-) (NEDD2-like caspase DRONC) [Cleaved into: Caspase Nc subunit 1; Caspase Nc subunit 2] Nc CG8091 Drosophila melanogaster (Fruit fly) TR2049_c0_g1_i1 P09117 ALDOC_RAT 1.00E-18 GO:0007568; GO:0006915; GO:0030424; GO:0005737; GO:0030388; GO:0004332; GO:0006096; GO:0005739; GO:0031100; GO:0051290; GO:0051289; GO:0001666; GO:0014070; GO:0010243 "aging; apoptotic process; axon; cytoplasm; fructose 1,6-bisphosphate metabolic process; fructose-bisphosphate aldolase activity; glycolysis; mitochondrion; organ regeneration; protein heterotetramerization; protein homotetramerization; response to hypoxia; response to organic cyclic compound; response to organonitrogen compound" IPR000741; IPR013785; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) Aldoc Rattus norvegicus (Rat) TR20491_c1_g1_i2 P48758 CBR1_MOUSE 2.00E-45 GO:0047021; GO:0004090; GO:0005737; GO:0017144; GO:0050221; GO:0042373 15-hydroxyprostaglandin dehydrogenase (NADP+) activity; carbonyl reductase (NADPH) activity; cytoplasm; drug metabolic process; prostaglandin-E2 9-reductase activity; vitamin K metabolic process IPR002198; IPR002347; IPR016040; IPR020904; Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.197) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) Cbr1 Cbr Mus musculus (Mouse) TR20492_c0_g1_i1 O70528 5HT4R_CAVPO 3.00E-14 GO:0005768; GO:0005887; GO:0032098; GO:0004993; GO:0007210; GO:0007268 endosome; integral to plasma membrane; regulation of appetite; serotonin receptor activity; serotonin receptor signaling pathway; synaptic transmission IPR001520; IPR000276; IPR017452; 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) HTR4 Cavia porcellus (Guinea pig) TR20495_c0_g1_i1 Q1WIM2 CADM2_RAT 3.00E-07 GO:0030424; GO:0007420; GO:0007155; GO:0030054; GO:0005737; GO:0016021; GO:0032809; GO:0045202 axon; brain development; cell adhesion; cell junction; cytoplasm; integral to membrane; neuronal cell body membrane; synapse IPR013162; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; IPR003585; Cell adhesion molecule 2 (Immunoglobulin superfamily member 4D) (IgSF4D) (Nectin-like protein 3) (NECL-3) (Synaptic cell adhesion molecule 2) (SynCAM 2) Cadm2 Igsf4d Necl3 Rattus norvegicus (Rat) TR20498_c0_g1_i1 P25867 UBCD1_DROME 2.00E-52 GO:0005524; GO:0051276; GO:0001751; GO:0008054; GO:0048132; GO:0030718; GO:0007140; GO:0005875; GO:0007067; GO:0016322; GO:0045676; GO:0031647; GO:0007286; GO:0004842 ATP binding; chromosome organization; compound eye photoreceptor cell differentiation; cyclin catabolic process; female germ-line stem cell division; germ-line stem cell maintenance; male meiosis; microtubule associated complex; mitosis; neuron remodeling; regulation of R7 cell differentiation; regulation of protein stability; spermatid development; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2-17 kDa (EC 6.3.2.19) (Protein effete) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) eff UbcD1 CG7425 Drosophila melanogaster (Fruit fly) TR20498_c0_g1_i2 P33296 UBC6_YEAST 5.00E-16 GO:0005524; GO:0030433; GO:0005789; GO:0016021; GO:0006513; GO:0000209; GO:0004842 P39940 ATP binding; ER-associated protein catabolic process; endoplasmic reticulum membrane; integral to membrane; protein monoubiquitination; protein polyubiquitination; ubiquitin-protein ligase activity IPR000608; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 6 (EC 6.3.2.19) (Ubiquitin carrier protein UBC6) (Ubiquitin-protein ligase UBC6) UBC6 DOA2 YER100W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR20503_c0_g1_i2 Q15399 TLR1_HUMAN 5.00E-11 GO:0002755; GO:0042088; GO:0035354; GO:0071727; GO:0042496; GO:0042495; GO:0006955; GO:0006954; GO:0045087; GO:0005887; GO:0042116; GO:0030670; GO:0045410; GO:0042535; GO:0046982; GO:0050707; GO:0034150; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; T-helper 1 type immune response; Toll-like receptor 1-Toll-like receptor 2 protein complex; cellular response to triacyl bacterial lipopeptide; detection of diacyl bacterial lipopeptide; detection of triacyl bacterial lipopeptide; immune response; inflammatory response; innate immune response; integral to plasma membrane; macrophage activation; phagocytic vesicle membrane; positive regulation of interleukin-6 biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; protein heterodimerization activity; regulation of cytokine secretion; toll-like receptor 6 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR000157; IPR027187; IPR017241; Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) TLR1 KIAA0012 Homo sapiens (Human) TR20504_c0_g1_i1 Q502M6 ANR29_DANRE 2.00E-35 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) TR20504_c0_g2_i1 Q8NFD2 ANKK1_HUMAN 2.00E-40 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR001245; IPR008271; Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) TR20504_c2_g1_i1 Q1RK13 Y220_RICBR 9.00E-41 IPR002110; IPR020683; Putative ankyrin repeat protein RBE_0220 RBE_0220 Rickettsia bellii (strain RML369-C) TR20504_c2_g2_i1 P16157 ANK1_HUMAN 6.00E-38 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR20506_c0_g1_i1 Q03206 RAC1_CAEEL 1.00E-36 GO:0005525; GO:0003924; GO:0006915; GO:0048846; GO:0031103; GO:0010171; GO:0009986; GO:0031410; GO:0005829; GO:0033563; GO:0043652; GO:0016021; GO:0009898; GO:0008045; GO:0002119; GO:0001764; GO:0030334; GO:0050764; GO:0007264 GTP binding; GTPase activity; apoptotic process; axon extension involved in axon guidance; axon regeneration; body morphogenesis; cell surface; cytoplasmic vesicle; cytosol; dorsal/ventral axon guidance; engulfment of apoptotic cell; integral to membrane; internal side of plasma membrane; motor neuron axon guidance; nematode larval development; neuron migration; regulation of cell migration; regulation of phagocytosis; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Ras-related protein ced-10 (CErac1) (Cell death protein 10) (Cell-corpse engulfment protein ced-10) (Ras-related protein rac-1) ced-10 rac-1 C09G12.8 Caenorhabditis elegans TR2051_c0_g1_i1 Q9C0D5 TANC1_HUMAN 4.00E-07 GO:0043679; GO:0030054; GO:0030425; GO:0097062; GO:0007520; GO:0043025; GO:0014069; GO:0045211; GO:0008542 axon terminus; cell junction; dendrite; dendritic spine maintenance; myoblast fusion; neuronal cell body; postsynaptic density; postsynaptic membrane; visual learning IPR002110; IPR020683; IPR027417; IPR013026; IPR011990; IPR013105; IPR019734; "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" TANC1 KIAA1728 Homo sapiens (Human) TR20538_c1_g1_i1 Q5R1W5 SRSF2_PANTR 3.00E-21 GO:0003723; GO:0008380; GO:0006397; GO:0016607; GO:0000166 RNA binding; RNA splicing; mRNA processing; nuclear speck; nucleotide binding IPR012677; IPR000504; "Serine/arginine-rich splicing factor 2 (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)" SRSF2 SFRS2 Pan troglodytes (Chimpanzee) TR20542_c5_g1_i1 Q9EP86 NPFF1_RAT 9.00E-07 GO:0016021; GO:0008188; GO:0007218; GO:0005886 integral to membrane; neuropeptide receptor activity; neuropeptide signaling pathway; plasma membrane IPR000276; IPR017452; IPR005395; IPR005396; Neuropeptide FF receptor 1 (G-protein coupled receptor 147) (RFamide-related peptide receptor OT7T022) Npffr1 Gpr147 Npff1 Rattus norvegicus (Rat) TR20549_c1_g2_i1 Q9R1T3 CATZ_RAT 1.00E-65 GO:0004197; GO:0005783; GO:0060441; GO:0005615; GO:0006508 cysteine-type endopeptidase activity; endoplasmic reticulum; epithelial tube branching involved in lung morphogenesis; extracellular space; proteolysis IPR025661; IPR013128; IPR000668; Cathepsin Z (EC 3.4.18.1) (Cathepsin Y) Ctsz Ctsy Rattus norvegicus (Rat) TR20550_c1_g1_i1 A9ULE9 DJC22_XENTR 6.00E-23 GO:0016021 integral to membrane IPR001623; IPR007829; DnaJ homolog subfamily C member 22 dnajc22 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR20555_c1_g1_i1 P22031 LEG_ANTCR 1.00E-14 GO:0030246; GO:0005737 carbohydrate binding; cytoplasm IPR000922; D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL) Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR20558_c1_g1_i1 Q8IY45 AMN1_HUMAN 1.00E-15 IPR026738; Protein AMN1 homolog AMN1 Homo sapiens (Human) TR2056_c0_g1_i1 P05933 CALM_SCHPO 2.00E-17 GO:0031322; GO:0000935; GO:0005509; GO:0032153; GO:0005829; GO:0071990; GO:0044732; GO:0035841; GO:0005634; GO:0035840; GO:0090307 O14188 ascospore-type prospore-specific spindle pole body remodeling; barrier septum; calcium ion binding; cell division site; cytosol; maintenance of protein location in spindle pole body; mitotic spindle pole body; new growing cell tip; nucleus; old growing cell tip; spindle assembly involved in mitosis IPR011992; IPR018247; IPR002048; Calmodulin (CaM) cam1 SPAC3A12.14 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR20562_c1_g1_i1 Q7TN73 CASD1_MOUSE 4.00E-64 GO:0016021 integral to membrane IPR012419; IPR013763; IPR026057; CAS1 domain-containing protein 1 Casd1 Cas1 Cast1 Mus musculus (Mouse) TR20566_c1_g2_i1 Q9Y4D1 DAAM1_HUMAN 8.00E-12 GO:0030036; GO:0005737; GO:0005886; GO:0001725 Itself; Q5T0N5; P61586; P00523; Q15642-2 actin cytoskeleton organization; cytoplasm; plasma membrane; stress fiber IPR011989; IPR016024; IPR027650; IPR014767; IPR015425; IPR010472; IPR010473; IPR014768; Disheveled-associated activator of morphogenesis 1 DAAM1 KIAA0666 Homo sapiens (Human) TR20569_c0_g1_i1 Q96IM9 DYDC2_HUMAN 6.00E-07 IPR007858; DPY30 domain-containing protein 2 DYDC2 Homo sapiens (Human) TR20570_c0_g1_i1 Q8VE42 ANR49_MOUSE 8.00E-11 GO:0045893 "positive regulation of transcription, DNA-dependent" IPR002110; IPR020683; Ankyrin repeat domain-containing protein 49 (Fetal globin-increasing factor) (Fetal globin-inducing factor) Ankrd49 Fgif Gbif Mus musculus (Mouse) TR20570_c0_g2_i1 Q02357 ANK1_MOUSE 2.00E-10 GO:0030863; GO:0048821; GO:0016020; GO:0015672; GO:0006779; GO:0016529; GO:0007165; GO:0014731 cortical cytoskeleton; erythrocyte development; membrane; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; sarcoplasmic reticulum; signal transduction; spectrin-associated cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) TR20570_c1_g1_i1 Q18297 TRPA1_CAEEL 5.00E-11 GO:0016021; GO:0005216; GO:0043025; GO:0031513; GO:0050896 integral to membrane; ion channel activity; neuronal cell body; nonmotile primary cilium; response to stimulus IPR002110; IPR020683; IPR005821; Transient receptor potential cation channel subfamily A member 1 homolog trpa-1 C29E6.2 Caenorhabditis elegans TR20578_c0_g1_i1 A5D7V7 S46A3_BOVIN 8.00E-10 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR016196; Solute carrier family 46 member 3 SLC46A3 Bos taurus (Bovine) TR20586_c1_g1_i1 Q9I931 FUCL1_ANGJA 1.00E-08 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-1 Anguilla japonica (Japanese eel) TR20588_c0_g1_i1 P16112 PGCA_HUMAN 1.00E-08 GO:0005796; GO:0030246; GO:0005975; GO:0007155; GO:0030198; GO:0005201; GO:0005576; GO:0005540; GO:0018146; GO:0042340; GO:0043202; GO:0046872; GO:0005578; GO:0006508; GO:0001501 Golgi lumen; carbohydrate binding; carbohydrate metabolic process; cell adhesion; extracellular matrix organization; extracellular matrix structural constituent; extracellular region; hyaluronic acid binding; keratan sulfate biosynthetic process; keratan sulfate catabolic process; lysosomal lumen; metal ion binding; proteinaceous extracellular matrix; proteolysis; skeletal system development IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR007110; IPR013783; IPR003006; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2] ACAN AGC1 CSPG1 MSK16 Homo sapiens (Human) TR20591_c0_g1_i1 Q9QZ05 E2AK4_MOUSE 2.00E-08 GO:0005524; GO:0009267; GO:0022626; GO:0030968; GO:0004694; GO:0017148; GO:0043558 ATP binding; cellular response to starvation; cytosolic ribosome; endoplasmic reticulum unfolded protein response; eukaryotic translation initiation factor 2alpha kinase activity; negative regulation of translation; regulation of translational initiation in response to stress IPR004154; IPR024435; IPR011009; IPR000719; IPR017441; IPR006575; IPR008271; IPR016255; IPR016135; Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2) Eif2ak4 Gcn2 Kiaa1338 Mus musculus (Mouse) TR20594_c0_g1_i1 Q9PRL8 ACBP_CHICK 8.00E-36 GO:0005794; GO:0005783; GO:0000062; GO:0008289; GO:0006810 Golgi apparatus; endoplasmic reticulum; fatty-acyl-CoA binding; lipid binding; transport IPR022408; IPR000582; IPR014352; Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) DBI Gallus gallus (Chicken) TR20597_c1_g1_i1 F1REV3 KRIT1_DANRE 2.00E-08 GO:0001525; GO:0072554; GO:0030054; GO:0005737; GO:0001886; GO:0003007; GO:0005874; GO:0045602; GO:0005886; GO:0007033; GO:0001570 angiogenesis; blood vessel lumenization; cell junction; cytoplasm; endothelial cell morphogenesis; heart morphogenesis; microtubule; negative regulation of endothelial cell differentiation; plasma membrane; vacuole organization; vasculogenesis IPR002110; IPR020683; IPR019749; IPR014352; IPR019748; IPR000299; Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog) (Santa) krit1 ccm1 san zgc:63585 Danio rerio (Zebrafish) (Brachydanio rerio) TR206_c0_g1_i1 G5E8K5 ANK3_MOUSE 3.00E-19 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR206_c0_g1_i2 Q4UKJ3 Y1087_RICFE 2.00E-07 IPR002110; IPR020683; Putative ankyrin repeat protein RF_1087 RF_1087 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR206_c0_g1_i3 Q6TGW5 OSTF1_DANRE 2.00E-06 GO:0005737 cytoplasm IPR002110; IPR020683; IPR000108; IPR001452; Osteoclast-stimulating factor 1 ostf1 Danio rerio (Zebrafish) (Brachydanio rerio) TR206_c0_g1_i4 Q3UMT1 PP12C_MOUSE 2.00E-07 GO:0005737 cytoplasm IPR002110; IPR020683; IPR017401; Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) Ppp1r12c Mbs85 Mus musculus (Mouse) TR2061_c0_g1_i1 Q6AYF9 IIGP5_RAT 7.00E-12 GO:0005525; GO:0016817; GO:0016020 "GTP binding; hydrolase activity, acting on acid anhydrides; membrane" IPR007743; IPR027417; Interferon-inducible GTPase 5 (EC 3.6.5.-) (Immunity-related GTPase cinema 1) Irgc Iigp5 Irgc1 Rattus norvegicus (Rat) TR2061_c0_g3_i1 Q8C262 IIGP5_MOUSE 4.00E-10 GO:0005525; GO:0016817; GO:0016020 "GTP binding; hydrolase activity, acting on acid anhydrides; membrane" IPR007743; IPR027417; Interferon-inducible GTPase 5 (EC 3.6.5.-) (Immunity-related GTPase cinema 1) Irgc Gm1102 Iigp5 Irgc1 Mus musculus (Mouse) TR20612_c0_g1_i1 Q96XY5 Y2383_SULTO 1.00E-15 IPR002589; Uncharacterized protein STK_23830 STK_23830 Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) TR20618_c0_g1_i1 Q869C3 ACES_ANOGA 3.00E-08 GO:0003990; GO:0004091; GO:0030054; GO:0019695; GO:0042135; GO:0045202; GO:0007271 "acetylcholinesterase activity; carboxylesterase activity; cell junction; choline metabolic process; neurotransmitter catabolic process; synapse; synaptic transmission, cholinergic" IPR002018; IPR019826; IPR019819; IPR000997; Acetylcholinesterase (AChE) (EC 3.1.1.7) Ace ACE1 ACHE1 AGAP001356 Anopheles gambiae (African malaria mosquito) TR20618_c0_g1_i2 Q64285 CEL_MOUSE 3.00E-14 GO:0047372; GO:0004091; GO:0046514; GO:0006707; GO:0005829; GO:0005615; GO:0030157; GO:0004771; GO:0004806 acylglycerol lipase activity; carboxylesterase activity; ceramide catabolic process; cholesterol catabolic process; cytosol; extracellular space; pancreatic juice secretion; sterol esterase activity; triglyceride lipase activity IPR002018; IPR019826; IPR019819; Bile salt-activated lipase (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Cholesterol esterase) (Pancreatic lysophospholipase) (Sterol esterase) Cel Lip1 Mus musculus (Mouse) TR20626_c0_g1_i1 Q7RTY0 MOT13_HUMAN 5.00E-07 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 13 (MCT 13) (Solute carrier family 16 member 13) SLC16A13 MCT13 Homo sapiens (Human) TR20630_c0_g2_i1 Q5ZIR9 RN185_CHICK 2.00E-06 GO:0006914; GO:0016021; GO:0016874; GO:0005741; GO:0016567; GO:0008270 autophagy; integral to membrane; ligase activity; mitochondrial outer membrane; protein ubiquitination; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF185 (EC 6.3.2.-) (RING finger protein 185) RNF185 RCJMB04_23p11 Gallus gallus (Chicken) TR20637_c0_g1_i1 Q3U145 TMM64_MOUSE 6.00E-24 GO:0051480; GO:0005783; GO:0016021; GO:0045780; GO:0045672; GO:0043462 cytosolic calcium ion homeostasis; endoplasmic reticulum; integral to membrane; positive regulation of bone resorption; positive regulation of osteoclast differentiation; regulation of ATPase activity IPR015414; Transmembrane protein 64 Tmem64 Mus musculus (Mouse) TR20641_c0_g1_i1 Q90688 MYPC3_CHICK 4.00E-11 GO:0001671; GO:0007155; GO:0032982; GO:0032971 ATPase activator activity; cell adhesion; myosin filament; regulation of muscle filament sliding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; "Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)" MYBPC3 Gallus gallus (Chicken) TR20646_c0_g1_i1 P23955 MPPA_NEUCR 6.00E-14 GO:0046872; GO:0004222; GO:0017087; GO:0006627; GO:0006508 metal ion binding; metalloendopeptidase activity; mitochondrial processing peptidase complex; protein processing involved in protein targeting to mitochondrion; proteolysis IPR011249; IPR011237; IPR011765; IPR001431; IPR007863; Mitochondrial-processing peptidase subunit alpha (EC 3.4.24.64) (Alpha-MPP) mpp NCU06270 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR20646_c0_g2_i1 P23004 QCR2_BOVIN 2.00E-40 GO:0046872; GO:0004222; GO:0005743; GO:0055114; GO:0006508; GO:0070469 metal ion binding; metalloendopeptidase activity; mitochondrial inner membrane; oxidation-reduction process; proteolysis; respiratory chain IPR011249; IPR011237; IPR011765; IPR001431; IPR007863; "Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2)" UQCRC2 Bos taurus (Bovine) TR20651_c1_g1_i1 P98074 ENTK_PIG 2.00E-07 GO:0016021; GO:0006508; GO:0005044; GO:0004252 integral to membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity IPR008985; IPR000859; IPR023415; IPR002172; IPR000998; IPR011163; IPR001254; IPR018114; IPR001314; IPR000082; IPR001190; IPR017448; IPR009003; Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic mini chain; Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain] TMPRSS15 ENTK PRSS7 Sus scrofa (Pig) TR20653_c0_g1_i1 Q9H2G2 SLK_HUMAN 3.00E-37 GO:0005524; GO:0006915; GO:0005737; GO:0005886; GO:0046777; GO:0042803; GO:0004674 Itself ATP binding; apoptotic process; cytoplasm; plasma membrane; protein autophosphorylation; protein homodimerization activity; protein serine/threonine kinase activity IPR011009; IPR022165; IPR000719; IPR017441; IPR002290; IPR008271; IPR001943; STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) SLK KIAA0204 STK2 Homo sapiens (Human) TR20656_c0_g1_i1 P67884 RL30_OPHHA 6.00E-63 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000231; IPR022991; IPR004038; 60S ribosomal protein L30 RPL30 Ophiophagus hannah (King cobra) (Naja hannah) TR20664_c3_g1_i1 Q13219 PAPP1_HUMAN 8.00E-94 GO:0030154; GO:0044267; GO:0004175; GO:0005576; GO:0005615; GO:0007565; GO:0016020; GO:0008237; GO:0006508; GO:0032354; GO:0051384; GO:0008270 cell differentiation; cellular protein metabolic process; endopeptidase activity; extracellular region; extracellular space; female pregnancy; membrane; metallopeptidase activity; proteolysis; response to follicle-stimulating hormone stimulus; response to glucocorticoid stimulus; zinc ion binding IPR008985; IPR013320; IPR006558; IPR024079; IPR011936; IPR000800; IPR008754; IPR000436; Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A) PAPPA Homo sapiens (Human) TR20672_c0_g1_i1 Q95NI4 CALM_HALOK 4.00E-44 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Halichondria okadai (Marine sponge) (Reniera okadai) TR20694_c0_g1_i1 Q8Q0U0 Y045_METMA 4.00E-24 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR20697_c1_g1_i1 B1LB08 XYLA_THESQ 2.00E-25 GO:0042732; GO:0005737; GO:0000287; GO:0006098; GO:0009045 D-xylose metabolic process; cytoplasm; magnesium ion binding; pentose-phosphate shunt; xylose isomerase activity IPR013022; IPR013452; IPR001998; Xylose isomerase (EC 5.3.1.5) xylA TRQ2_1162 Thermotoga sp. (strain RQ2) TR20697_c2_g1_i1 Q3BMF2 XYLA_XANC5 1.00E-31 GO:0042732; GO:0005737; GO:0000287; GO:0006098; GO:0009045 D-xylose metabolic process; cytoplasm; magnesium ion binding; pentose-phosphate shunt; xylose isomerase activity IPR013022; IPR013452; IPR001998; Xylose isomerase (EC 5.3.1.5) xylA1 XCV1808 XCV4330 Xanthomonas campestris pv. vesicatoria (strain 85-10) TR20702_c0_g1_i1 Q6W5P4 NPSR1_HUMAN 6.00E-10 GO:0005737; GO:0016021; GO:0008188; GO:0007218; GO:0005886; GO:0005000 cytoplasm; integral to membrane; neuropeptide receptor activity; neuropeptide signaling pathway; plasma membrane; vasopressin receptor activity IPR000276; IPR017452; IPR027294; IPR001817; Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) (G-protein coupled receptor for asthma susceptibility) NPSR1 GPR154 GPRA PGR14 Homo sapiens (Human) TR20704_c3_g1_i2 Q9DD78 TLR21_CHICK 1.00E-11 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0005886; GO:0050729; GO:0050707; GO:0002237; GO:0035681; GO:0034134; GO:0034142; GO:0034146; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; plasma membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 15 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR018247; IPR001611; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 type-1 TLR2-1 Gallus gallus (Chicken) TR20705_c1_g1_i1 Q13263 TIF1B_HUMAN 7.00E-06 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR20712_c1_g1_i1 Q9VYS3 RENT1_DROME 5.00E-13 GO:0005524; GO:0003677; GO:0071456; GO:0005737; GO:0004386; GO:0000184; GO:2000624; GO:0008270 "ATP binding; DNA binding; cellular response to hypoxia; cytoplasm; helicase activity; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; zinc ion binding" IPR027417; IPR018999; Regulator of nonsense transcripts 1 homolog (EC 3.6.4.-) Upf1 CG1559 Drosophila melanogaster (Fruit fly) TR20712_c1_g2_i1 Q9BYK8 PR285_HUMAN 2.00E-17 GO:0005524; GO:0003677; GO:0044255; GO:0004386; GO:0030374; GO:0046872; GO:0005654; GO:0045944; GO:0044281; GO:0006351 "ATP binding; DNA binding; cellular lipid metabolic process; helicase activity; ligand-dependent nuclear receptor transcription coactivator activity; metal ion binding; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; small molecule metabolic process; transcription, DNA-dependent" IPR003593; IPR026122; IPR012340; IPR027417; IPR022966; IPR015880; "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) TR20712_c1_g3_i1 P30771 NAM7_YEAST 4.00E-16 GO:0005524; GO:0004004; GO:0003677; GO:0030466; GO:0005737; GO:0008298; GO:0070478; GO:0003676; GO:0005634; GO:0005844; GO:0016567; GO:0006449; GO:0043024; GO:0008270 "ATP binding; ATP-dependent RNA helicase activity; DNA binding; chromatin silencing at silent mating-type cassette; cytoplasm; intracellular mRNA localization; nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; nucleic acid binding; nucleus; polysome; protein ubiquitination; regulation of translational termination; ribosomal small subunit binding; zinc ion binding" IPR003593; IPR014001; IPR027417; IPR018999; ATP-dependent helicase NAM7 (EC 3.6.4.-) (Nonsense-mediated mRNA decay protein 1) (Nuclear accommodation of mitochondria 7 protein) (Up-frameshift suppressor 1) NAM7 IFS2 MOF4 UPF1 YMR080C YM9582.05C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR20719_c0_g1_i2 Q9H0Y0 ATG10_HUMAN 2.00E-34 GO:0019777; GO:0034263; GO:0005737; GO:0005622; GO:0031401; GO:0006497; GO:0032446; GO:0015031 O94817; O95166; Q9H0R8; P60520; Q9GZQ8; Q9BXW4 Atg12 ligase activity; autophagy in response to ER overload; cytoplasm; intracellular; positive regulation of protein modification process; protein lipidation; protein modification by small protein conjugation; protein transport IPR007135; Ubiquitin-like-conjugating enzyme ATG10 (EC 6.3.2.-) (Autophagy-related protein 10) (APG10-like) ATG10 APG10L PP12616 Homo sapiens (Human) TR20720_c0_g1_i1 P55068 PGCB_RAT 2.00E-10 GO:0031225; GO:0030246; GO:0007155; GO:0030425; GO:0005615; GO:0005540; GO:0005578; GO:0048168; GO:0045202 anchored to membrane; carbohydrate binding; cell adhesion; dendrite; extracellular space; hyaluronic acid binding; proteinaceous extracellular matrix; regulation of neuronal synaptic plasticity; synapse IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR007110; IPR013783; IPR003006; IPR013106; IPR003596; IPR000538; IPR000436; Brevican core protein (Brain-enriched hyaluronan-binding protein) (BEHAB) Bcan Behab Rattus norvegicus (Rat) TR20724_c1_g1_i1 Q7Z418 KCNKI_HUMAN 9.00E-29 GO:0015269; GO:0071467; GO:0005887; GO:0015271; GO:0071435; GO:0007268 calcium-activated potassium channel activity; cellular response to pH; integral to plasma membrane; outward rectifier potassium channel activity; potassium ion export; synaptic transmission IPR003280; IPR013099; Potassium channel subfamily K member 18 (TWIK-related individual potassium channel) (TWIK-related spinal cord potassium channel) KCNK18 TRESK TRIK Homo sapiens (Human) TR20727_c0_g1_i1 Q9CQ86 MIEN1_MOUSE 2.00E-07 GO:0006915; GO:0045454; GO:0005829; GO:0031235; GO:0043066; GO:0030335; GO:0051491; GO:0008430 apoptotic process; cell redox homeostasis; cytosol; intrinsic to internal side of plasma membrane; negative regulation of apoptotic process; positive regulation of cell migration; positive regulation of filopodium assembly; selenium binding IPR011893; IPR012336; Migration and invasion enhancer 1 Mien1 Rdx12 Mus musculus (Mouse) TR20730_c1_g1_i1 P78539 SRPX_HUMAN 2.00E-09 GO:0005776; GO:0006914; GO:0007155; GO:0009986; GO:0033554; GO:0005783; GO:0016020; GO:0060244; GO:0001845; GO:0043065 autophagic vacuole; autophagy; cell adhesion; cell surface; cellular response to stress; endoplasmic reticulum; membrane; negative regulation of cell proliferation involved in contact inhibition; phagolysosome assembly; positive regulation of apoptotic process IPR025232; IPR003410; IPR000436; Sushi repeat-containing protein SRPX SRPX ETX1 Homo sapiens (Human) TR20740_c1_g1_i1 P14410 SUIS_HUMAN 2.00E-15 GO:0005794; GO:0016324; GO:0005903; GO:0030246; GO:0005975; GO:0016021; GO:0004574; GO:0005886; GO:0044245; GO:0044281; GO:0004575 "Golgi apparatus; apical plasma membrane; brush border; carbohydrate binding; carbohydrate metabolic process; integral to membrane; oligo-1,6-glucosidase activity; plasma membrane; polysaccharide digestion; small molecule metabolic process; sucrose alpha-glucosidase activity" IPR011013; IPR000322; IPR017853; IPR000519; IPR017957; "Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]" SI Homo sapiens (Human) TR20746_c3_g1_i2 Q69YW0 CA222_HUMAN 7.00E-12 IPR008962; Uncharacterized protein C1orf222 C1orf222 Homo sapiens (Human) TR20753_c1_g1_i1 Q9JMK0 B4GT5_MOUSE 6.00E-15 GO:0032580; GO:0016021; GO:0046872; GO:0006486; GO:0016757 "Golgi cisterna membrane; integral to membrane; metal ion binding; protein glycosylation; transferase activity, transferring glycosyl groups" IPR003859; IPR027791; IPR027995; Protein modification; protein glycosylation. "Beta-1,4-galactosyltransferase 5 (Beta-1,4-GalTase 5) (Beta4Gal-T5) (b4Gal-T5) (EC 2.4.1.-) (Beta-1,4-GalT II) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5)" B4galt5 Bgt-5 Mus musculus (Mouse) TR20755_c3_g1_i1 Q15276 RABE1_HUMAN 5.00E-23 GO:0005096; GO:0006915; GO:0005769; GO:0030139; GO:0006897; GO:0061025; GO:0043547; GO:0015031; GO:0055037 O43747; O75843; Q9UJY5; Q9UJY4; Q9NZ52 GTPase activator activity; apoptotic process; early endosome; endocytic vesicle; endocytosis; membrane fusion; positive regulation of GTPase activity; protein transport; recycling endosome IPR003914; IPR018514; IPR015390; Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) RABEP1 RAB5EP RABPT5 RABPT5A Homo sapiens (Human) TR20761_c2_g1_i1 P09848 LPH_HUMAN 4.00E-32 GO:0016324; GO:0005975; GO:0017042; GO:0005887; GO:0000016; GO:0044245; GO:0044281 apical plasma membrane; carbohydrate metabolic process; glycosylceramidase activity; integral to plasma membrane; lactase activity; polysaccharide digestion; small molecule metabolic process IPR001360; IPR018120; IPR013781; IPR017853; Lactase-phlorizin hydrolase (Lactase-glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Phlorizin hydrolase (EC 3.2.1.62)] LCT LPH Homo sapiens (Human) TR20761_c3_g1_i1 Q0DA21 BGL25_ORYSJ 6.00E-20 GO:0008422; GO:0005975 beta-glucosidase activity; carbohydrate metabolic process IPR001360; IPR018120; IPR013781; IPR017853; Beta-glucosidase 25 (Os6bglu25) (EC 3.2.1.21) BGLU25 Os06g0683300 LOC_Os06g46940 Oryza sativa subsp. japonica (Rice) TR20761_c3_g1_i2 Q02401 LPH_RAT 2.00E-28 GO:0016324; GO:0005903; GO:0005975; GO:0017042; GO:0016021; GO:0000016; GO:0042493; GO:0043627; GO:0045471; GO:0001666; GO:0010040; GO:0010288; GO:0010045; GO:0007584; GO:0042594; GO:0009744; GO:0016740 apical plasma membrane; brush border; carbohydrate metabolic process; glycosylceramidase activity; integral to membrane; lactase activity; response to drug; response to estrogen stimulus; response to ethanol; response to hypoxia; response to iron(II) ion; response to lead ion; response to nickel cation; response to nutrient; response to starvation; response to sucrose stimulus; transferase activity IPR001360; IPR018120; IPR013781; IPR017853; Lactase-phlorizin hydrolase (Lactase-glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Phlorizin hydrolase (EC 3.2.1.62)] Lct Lph Rattus norvegicus (Rat) TR20761_c4_g1_i1 Q99N32 KLOTB_MOUSE 4.00E-31 GO:0005975; GO:0004553; GO:0016021; GO:0005886; GO:0090080; GO:0008284 "carbohydrate metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; integral to membrane; plasma membrane; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway; positive regulation of cell proliferation" IPR001360; IPR018120; IPR013781; IPR017853; Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein) Klb Betakl Mus musculus (Mouse) TR20765_c0_g1_i1 P22001 KCNA3_HUMAN 1.00E-38 GO:0005251; GO:0045121; GO:0015271; GO:0051260; GO:0007268; GO:0008076 delayed rectifier potassium channel activity; membrane raft; outward rectifier potassium channel activity; protein homooligomerization; synaptic transmission; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003972; IPR004050; IPR003131; IPR028325; Potassium voltage-gated channel subfamily A member 3 (HGK5) (HLK3) (HPCN3) (Voltage-gated K(+) channel HuKIII) (Voltage-gated potassium channel subunit Kv1.3) KCNA3 HGK5 Homo sapiens (Human) TR20767_c0_g1_i1 Q9CSP9 TTC14_MOUSE 4.00E-36 GO:0003723 RNA binding IPR012340; IPR003029; IPR022967; IPR013026; IPR011990; IPR019734; Tetratricopeptide repeat protein 14 (TPR repeat protein 14) Ttc14 Kiaa1980 Mus musculus (Mouse) TR20768_c2_g1_i2 Q99K43 PRC1_MOUSE 1.00E-09 GO:0000910; GO:0005737; GO:0005874; GO:0000226; GO:0005634; GO:0005819; GO:0000922 cytokinesis; cytoplasm; microtubule; microtubule cytoskeleton organization; nucleus; spindle; spindle pole IPR007145; Protein regulator of cytokinesis 1 Prc1 Mus musculus (Mouse) TR20771_c1_g2_i1 P21927 CHLE_RABIT 8.00E-10 GO:0003990; GO:0004091; GO:0005576; GO:0016020 acetylcholinesterase activity; carboxylesterase activity; extracellular region; membrane IPR014788; IPR002018; IPR019826; IPR019819; IPR000997; Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase) BCHE Oryctolagus cuniculus (Rabbit) TR20776_c1_g1_i1 P07692 ACES_TORMA 3.00E-19 GO:0001507; GO:0003990; GO:0031225; GO:0004091; GO:0030054; GO:0005886; GO:0045202 acetylcholine catabolic process in synaptic cleft; acetylcholinesterase activity; anchored to membrane; carboxylesterase activity; cell junction; plasma membrane; synapse IPR000908; IPR002018; IPR019826; IPR019819; IPR000997; Acetylcholinesterase (AChE) (EC 3.1.1.7) ache Torpedo marmorata (Marbled electric ray) TR20782_c0_g1_i1 Q7TM99 MOT9_MOUSE 7.00E-27 GO:0016021; GO:0005886; GO:0015293; GO:0046415 integral to membrane; plasma membrane; symporter activity; urate metabolic process IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) Slc16a9 Mct9 Mus musculus (Mouse) TR20782_c0_g2_i1 Q90632 MOT3_CHICK 2.00E-18 GO:0016021; GO:0005886; GO:0015355; GO:0015293 integral to membrane; plasma membrane; secondary active monocarboxylate transmembrane transporter activity; symporter activity IPR011701; IPR020846; IPR016196; IPR004743; Monocarboxylate transporter 3 (MCT 3) (Retinal epithelial membrane protein) (Solute carrier family 16 member 8) SLC16A3 MCT3 REMP Gallus gallus (Chicken) TR20782_c0_g3_i1 Q5ZJU0 MOT9_CHICK 3.00E-27 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 MCT9 RCJMB04_15m4 Gallus gallus (Chicken) TR20783_c2_g1_i1 Q92547 TOPB1_HUMAN 2.00E-21 GO:0003677; GO:0006281; GO:0016605; GO:0005694; GO:0000794; GO:0005737; GO:0001673; GO:0005815; GO:0008022; GO:0010212; GO:0000922 Itself; P31749; O75419; P03120; Q01094; Q13105 DNA binding; DNA repair; PML body; chromosome; condensed nuclear chromosome; cytoplasm; male germ cell nucleus; microtubule organizing center; protein C-terminus binding; response to ionizing radiation; spindle pole IPR001357; IPR016126; IPR026993; DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) TOPBP1 KIAA0259 Homo sapiens (Human) TR20787_c1_g1_i1 Q09524 TG124_CAEEL 5.00E-24 GO:0003723; GO:0009982; GO:0001522; GO:0008033 RNA binding; pseudouridine synthase activity; pseudouridine synthesis; tRNA processing IPR020103; IPR001406; IPR020097; IPR020095; IPR020094; Probable tRNA pseudouridine synthase tag-124 (EC 5.4.99.-) (tRNA pseudouridylate synthase) (tRNA-uridine isomerase) tag-124 E02H1.3 Caenorhabditis elegans TR20787_c1_g1_i2 Q3SX07 PUS3_BOVIN 1.00E-49 GO:0003723; GO:0005634; GO:0009982; GO:0001522; GO:0008033 RNA binding; nucleus; pseudouridine synthase activity; pseudouridine synthesis; tRNA processing IPR020103; IPR001406; IPR020097; IPR020095; IPR020094; tRNA pseudouridine(38/39) synthase (EC 5.4.99.45) (tRNA pseudouridine synthase 3) (tRNA pseudouridylate synthase 3) (tRNA-uridine isomerase 3) PUS3 Bos taurus (Bovine) TR20789_c1_g1_i1 O70628 PDE9A_MOUSE 2.00E-53 GO:0047555; GO:0005829; GO:0046872; GO:0007165 "3',5'-cyclic-GMP phosphodiesterase activity; cytosol; metal ion binding; signal transduction" IPR003607; IPR023088; IPR002073; IPR023174; "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35)" Pde9a Pde8b Mus musculus (Mouse) TR20791_c1_g1_i1 Q96DM1 PGBD4_HUMAN 8.00E-19 PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) TR20801_c0_g1_i1 O88280 SLIT3_RAT 5.00E-09 GO:0007420; GO:0005509; GO:0030154; GO:0005576; GO:0016020; GO:0021510 brain development; calcium ion binding; cell differentiation; extracellular region; membrane; spinal cord development IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 3 protein (Slit-3) (Multiple epidermal growth factor-like domains protein 5) (Multiple EGF-like domains protein 5) Slit3 Megf5 Rattus norvegicus (Rat) TR20815_c0_g1_i2 Q4UMH6 Y381_RICFE 7.00E-13 GO:0015969 guanosine tetraphosphate metabolic process IPR002110; IPR020683; IPR007685; Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR20815_c0_g1_i3 Q812A3 ANR23_MOUSE 4.00E-07 GO:0031674; GO:0015629; GO:0006631; GO:0005634 I band; actin cytoskeleton; fatty acid metabolic process; nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) Ankrd23 Darp Mus musculus (Mouse) TR20826_c0_g1_i1 Q6UVM4 KCNT2_RAT 2.00E-09 GO:0005524; GO:0015269; GO:0005228; GO:0005249; GO:0008076 ATP binding; calcium-activated potassium channel activity; intracellular sodium activated potassium channel activity; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR013099; IPR003929; IPR016040; Potassium channel subfamily T member 2 (Sequence like an intermediate conductance potassium channel subunit) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1) Kcnt2 Slick Rattus norvegicus (Rat) TR20830_c1_g1_i1 Q6NSZ9 ZN498_HUMAN 5.00E-08 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 25 (Zinc finger protein 498) ZSCAN25 ZNF498 Homo sapiens (Human) TR20830_c1_g2_i1 P13360 GLAS_DROME 1.00E-12 GO:0003677; GO:0003705; GO:0001752; GO:0043153; GO:0046872; GO:0005634; GO:0045944; GO:0010114; GO:0035271; GO:0007605; GO:0007601 DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; compound eye photoreceptor fate commitment; entrainment of circadian clock by photoperiod; metal ion binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; response to red light; ring gland development; sensory perception of sound; visual perception IPR007087; IPR015880; IPR013087; Protein glass gl CG7672 Drosophila melanogaster (Fruit fly) TR20837_c3_g1_i1 Q26430 ABDA_MANSE 1.00E-30 GO:0007275; GO:0005634; GO:0043565; GO:0003700 multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR022132; IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein abdominal-A homolog (Fragment) ABD-A Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) TR20841_c1_g1_i1 Q61122 NAB1_MOUSE 7.00E-08 GO:0014037; GO:0001958; GO:0042552; GO:0045892; GO:0005634; GO:0045682; GO:0006355; GO:0008134; GO:0006351 "Schwann cell differentiation; endochondral ossification; myelination; negative regulation of transcription, DNA-dependent; nucleus; regulation of epidermis development; regulation of transcription, DNA-dependent; transcription factor binding; transcription, DNA-dependent" IPR006986; IPR006989; IPR006988; NGFI-A-binding protein 1 (EGR-1-binding protein 1) Nab1 Mus musculus (Mouse) TR20848_c2_g1_i1 P24463 CP3AC_CANFA 7.00E-19 GO:0070330; GO:0005789; GO:0020037; GO:0005506; GO:0004497 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity IPR001128; IPR017972; IPR008072; IPR002402; Cytochrome P450 3A12 (EC 1.14.14.1) (CYPIIIA12) (Cytochrome P450-PBD-1) CYP3A12 Canis familiaris (Dog) (Canis lupus familiaris) TR20849_c2_g1_i1 Q6PR54 RIF1_MOUSE 2.00E-27 GO:0007049; GO:0000781; GO:0005737; GO:0001939; GO:0001940; GO:0006974; GO:0005819; GO:0019827; GO:0000723 Q80Z64; Q61066 "cell cycle; chromosome, telomeric region; cytoplasm; female pronucleus; male pronucleus; response to DNA damage stimulus; spindle; stem cell maintenance; telomere maintenance" IPR016024; IPR022031; Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) (mRif1) Rif1 Mus musculus (Mouse) TR2085_c0_g1_i1 Q0MQ89 NDUAD_GORGO 5.00E-22 GO:0008137; GO:0030262; GO:0097190; GO:0016021; GO:0005747; GO:0030308; GO:2001243; GO:0045892; GO:0017148; GO:0005654; GO:0072593 "NADH dehydrogenase (ubiquinone) activity; apoptotic nuclear changes; apoptotic signaling pathway; integral to membrane; mitochondrial respiratory chain complex I; negative regulation of cell growth; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of transcription, DNA-dependent; negative regulation of translation; nucleoplasm; reactive oxygen species metabolic process" IPR009346; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (Complex I-B16.6) (CI-B16.6) (NADH-ubiquinone oxidoreductase B16.6 subunit) NDUFA13 Gorilla gorilla gorilla (Lowland gorilla) TR20850_c7_g1_i1 Q6NXP0 EFC12_HUMAN 2.00E-07 GO:0005509 calcium ion binding IPR002048; EF-hand calcium-binding domain-containing protein 12 EFCAB12 C3orf25 Homo sapiens (Human) TR20851_c5_g1_i1 O93327 H2AY_CHICK 1.00E-09 GO:0003677; GO:0016568; GO:0000786; GO:0006334; GO:0005634 DNA binding; chromatin modification; nucleosome; nucleosome assembly; nucleus IPR021171; IPR009072; IPR007125; IPR002119; IPR002589; Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (H2A.y) (H2A/y) H2AFY Gallus gallus (Chicken) TR20851_c6_g2_i1 Q8CFF0 PAR11_MOUSE 2.00E-12 GO:0003950 NAD+ ADP-ribosyltransferase activity IPR012317; IPR004170; Poly [ADP-ribose] polymerase 11 (PARP-11) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 11) (ARTD11) Parp11 Mus musculus (Mouse) TR20859_c1_g1_i1 O35161 CELR1_MOUSE 4.00E-34 GO:0004930; GO:0007266; GO:0009952; GO:0045176; GO:0005509; GO:0007267; GO:0007417; GO:0048105; GO:0042249; GO:0001702; GO:0001942; GO:0007156; GO:0042472; GO:0005887; GO:0060490; GO:0007626; GO:0001843; GO:0001764; GO:0007218; GO:0060488; GO:0090179; GO:0060489; GO:0046983; GO:0090251; GO:0032956; GO:0046928; GO:0042060 Q7T0S3 G-protein coupled receptor activity; Rho protein signal transduction; anterior/posterior pattern specification; apical protein localization; calcium ion binding; cell-cell signaling; central nervous system development; establishment of body hair planar orientation; establishment of planar polarity of embryonic epithelium; gastrulation with mouth forming second; hair follicle development; homophilic cell adhesion; inner ear morphogenesis; integral to plasma membrane; lateral sprouting involved in lung morphogenesis; locomotory behavior; neural tube closure; neuron migration; neuropeptide signaling pathway; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis; planar cell polarity pathway involved in neural tube closure; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis; protein dimerization activity; protein localization involved in establishment of planar polarity; regulation of actin cytoskeleton organization; regulation of neurotransmitter secretion; wound healing IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR013032; IPR000152; IPR002049; IPR017981; IPR001879; IPR000832; IPR000203; IPR009030; IPR001791; Cadherin EGF LAG seven-pass G-type receptor 1 Celsr1 Mus musculus (Mouse) TR20859_c2_g1_i1 O88278 CELR3_RAT 2.00E-34 GO:0004930; GO:0007413; GO:0005509; GO:0042384; GO:0007156; GO:0016021; GO:0001764; GO:0007218; GO:0005886; GO:0032880 G-protein coupled receptor activity; axonal fasciculation; calcium ion binding; cilium assembly; homophilic cell adhesion; integral to membrane; neuron migration; neuropeptide signaling pathway; plasma membrane; regulation of protein localization IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR013032; IPR002049; IPR017981; IPR001879; IPR000832; IPR017983; IPR000203; IPR001791; Cadherin EGF LAG seven-pass G-type receptor 3 (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) Celsr3 Megf2 Rattus norvegicus (Rat) TR20864_c0_g1_i1 Q149C3 LIGO4_MOUSE 2.00E-12 GO:0016021 integral to membrane IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeat and immunoglobulin-like domain containing-NOGO receptor-interacting protein 4 (Leucine-rich repeat neuronal protein 6D) Lingo4 Lrrn6d Mus musculus (Mouse) TR20866_c0_g1_i1 A6NDR6 ME3L1_HUMAN 7.00E-19 GO:0005634; GO:0043565; GO:0003700 nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR001356; IPR008422; IPR009057; Putative homeobox protein Meis3-like 1 MEIS3P1 Homo sapiens (Human) TR20866_c1_g1_i1 O46339 HTH_DROME 6.00E-31 GO:0003677; GO:0003705; GO:0007420; GO:0001752; GO:0005737; GO:0048735; GO:0007480; GO:0007476; GO:0007479; GO:0005634; GO:0007422; GO:0045944; GO:0000060; GO:0042659; GO:0045664; GO:0007432; GO:0043565; GO:0007525; GO:0010092; GO:0007383; GO:0005667 P40427 "DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; brain development; compound eye photoreceptor fate commitment; cytoplasm; haltere morphogenesis; imaginal disc-derived leg morphogenesis; imaginal disc-derived wing morphogenesis; leg disc proximal/distal pattern formation; nucleus; peripheral nervous system development; positive regulation of transcription from RNA polymerase II promoter; protein import into nucleus, translocation; regulation of cell fate specification; regulation of neuron differentiation; salivary gland boundary specification; sequence-specific DNA binding; somatic muscle development; specification of organ identity; specification of segmental identity, antennal segment; transcription factor complex" IPR001356; IPR008422; IPR009057; Homeobox protein homothorax (Homeobox protein dorsotonals) hth dtl CG17117 Drosophila melanogaster (Fruit fly) TR20866_c1_g2_i1 Q5R6L1 PKNX2_PONAB 1.00E-36 GO:0005634; GO:0043565; GO:0003700 nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR001356; IPR008422; IPR009057; Homeobox protein PKNOX2 (PBX/knotted homeobox 2) PKNOX2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR20867_c0_g1_i1 Q502K3 ANR52_DANRE 7.00E-12 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) TR20867_c0_g1_i3 Q5DW34 EHMT1_MOUSE 2.00E-15 GO:0006306; GO:0005694; GO:0009790; GO:0046976; GO:0046974; GO:0000122; GO:0005634; GO:0018027; GO:0018026; GO:0008270 DNA methylation; chromosome; embryo development; histone methyltransferase activity (H3-K27 specific); histone methyltransferase activity (H3-K9 specific); negative regulation of transcription from RNA polymerase II promoter; nucleus; peptidyl-lysine dimethylation; peptidyl-lysine monomethylation; zinc ion binding IPR002110; IPR020683; IPR007728; IPR003606; IPR001214; Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Lysine N-methyltransferase 1D) Ehmt1 Euhmtase1 Glp Kmt1d Mus musculus (Mouse) TR20868_c0_g1_i1 Q7RTS9 DYM_HUMAN 3.00E-32 GO:0005794; GO:0007030; GO:0060348; GO:0005634; GO:0005886 Golgi apparatus; Golgi organization; bone development; nucleus; plasma membrane IPR019142; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) DYM Homo sapiens (Human) TR20872_c0_g1_i1 P0CK97 S35E2_HUMAN 3.00E-14 GO:0016021 integral to membrane IPR000620; Solute carrier family 35 member E2 SLC35E2 Homo sapiens (Human) TR20872_c0_g2_i1 P0CK97 S35E2_HUMAN 6.00E-13 GO:0016021 integral to membrane IPR000620; Solute carrier family 35 member E2 SLC35E2 Homo sapiens (Human) TR20879_c0_g1_i1 P02553 TBA_LYTPI 6.00E-50 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; Tubulin alpha chain (Fragment) Lytechinus pictus (Painted sea urchin) TR2088_c1_g1_i1 Q6YHK3 CD109_HUMAN 3.00E-12 GO:0031225; GO:0005615; GO:0010951; GO:0005886; GO:0004867 anchored to membrane; extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) TR20880_c0_g1_i1 Q9XSK2 CD63_BOVIN 4.00E-08 GO:0016021; GO:0031902; GO:0005765; GO:0005886 integral to membrane; late endosome membrane; lysosomal membrane; plasma membrane IPR000301; IPR018499; IPR018503; IPR008952; CD63 antigen (CD antigen CD63) CD63 Bos taurus (Bovine) TR20897_c1_g1_i1 Q8UW76 TBX20_CHICK 6.00E-59 GO:0000977; GO:0001105; GO:0003180; GO:0060413; GO:0008015; GO:0003207; GO:0055008; GO:0003215; GO:0008283; GO:0005737; GO:0009953; GO:0036306; GO:0003272; GO:0035922; GO:0001947; GO:0006936; GO:0010991; GO:0000122; GO:0001764; GO:0005634; GO:0003148; GO:0001569; GO:0003344; GO:0060045; GO:0003193; GO:0060577; GO:0003700; GO:0003175; GO:0021524 RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription coactivator activity; aortic valve morphogenesis; atrial septum morphogenesis; blood circulation; cardiac chamber formation; cardiac muscle tissue morphogenesis; cardiac right ventricle morphogenesis; cell proliferation; cytoplasm; dorsal/ventral pattern formation; embryonic heart tube elongation; endocardial cushion formation; foramen ovale closure; heart looping; muscle contraction; negative regulation of SMAD protein complex assembly; negative regulation of transcription from RNA polymerase II promoter; neuron migration; nucleus; outflow tract septum morphogenesis; patterning of blood vessels; pericardium morphogenesis; positive regulation of cardiac muscle cell proliferation; pulmonary valve formation; pulmonary vein morphogenesis; sequence-specific DNA binding transcription factor activity; tricuspid valve development; visceral motor neuron differentiation IPR008967; IPR001699; IPR018186; T-box transcription factor TBX20 (T-box protein 20) (cTbx20) TBX20 Gallus gallus (Chicken) TR20898_c0_g1_i1 A5D8S5 SH3R1_DANRE 2.00E-26 GO:0005794; GO:0030027; GO:0016874; GO:0048471; GO:0016567; GO:0008270 Golgi apparatus; lamellipodium; ligase activity; perinuclear region of cytoplasm; protein ubiquitination; zinc ion binding IPR000108; IPR001452; IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase SH3RF1 (EC 6.3.2.-) (Plenty of SH3s) (Protein POSH) (SH3 domain-containing RING finger protein 1) sh3rf1 posh si:dkey-15j16.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR20898_c1_g2_i1 Q8TEC5 SH3R2_HUMAN 2.00E-18 GO:0016874; GO:0010923; GO:0008157; GO:0004864; GO:0016567; GO:0008270 P62136 ligase activity; negative regulation of phosphatase activity; protein phosphatase 1 binding; protein phosphatase inhibitor activity; protein ubiquitination; zinc ion binding IPR011511; IPR001452; IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Putative E3 ubiquitin-protein ligase SH3RF2 (EC 6.3.2.-) (Heart protein phosphatase 1-binding protein) (HEPP1) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (SH3 domain-containing RING finger protein 2) SH3RF2 PPP1R39 RNF158 Homo sapiens (Human) TR20898_c1_g3_i1 Q8C120 SH3R3_MOUSE 9.00E-24 GO:0008270 zinc ion binding IPR000108; IPR001452; IPR018957; IPR001841; IPR013083; IPR017907; SH3 domain-containing RING finger protein 3 (Plenty of SH3s 2) (SH3 multiple domains protein 4) Sh3rf3 Posh2 Sh3md4 Mus musculus (Mouse) TR20903_c0_g1_i2 Q8HYJ4 FUT5_PONPY 3.00E-39 GO:0017060; GO:0032580; GO:0036065; GO:0016021; GO:0006486 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity; Golgi cisterna membrane; fucosylation; integral to membrane; protein glycosylation IPR001503; Protein modification; protein glycosylation. "Alpha-(1,3)-fucosyltransferase 5 (EC 2.4.1.65) (Fucosyltransferase 5) (Fucosyltransferase V) (Fuc-TV) (FucT-V) (Galactoside 3-L-fucosyltransferase)" FUT5 Pongo pygmaeus (Bornean orangutan) TR20906_c0_g1_i1 O00750 P3C2B_HUMAN 1.00E-23 GO:0016303; GO:0035005; GO:0005524; GO:0030139; GO:0005783; GO:0043231; GO:0001727; GO:0005634; GO:0005942; GO:0035091; GO:0048015; GO:0005886; GO:0043491; GO:0044281 P00533; P04626; P62993; P16333; P14373 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; endocytic vesicle; endoplasmic reticulum; intracellular membrane-bounded organelle; lipid kinase activity; nucleus; phosphatidylinositol 3-kinase complex; phosphatidylinositol binding; phosphatidylinositol-mediated signaling; plasma membrane; protein kinase B signaling cascade; small molecule metabolic process IPR016024; IPR000008; IPR011009; IPR001683; IPR000403; IPR018936; IPR002420; IPR000341; IPR015433; IPR001263; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta) PIK3C2B Homo sapiens (Human) TR20913_c0_g1_i1 P36958 RPB9_DROME 1.00E-69 GO:0003677; GO:0005665; GO:0003899; GO:0007067; GO:0007095; GO:0022008; GO:0006366; GO:0008270 "DNA binding; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase activity; mitosis; mitotic G2 DNA damage checkpoint; neurogenesis; transcription from RNA polymerase II promoter; zinc ion binding" IPR019761; IPR001529; IPR012164; IPR001222; DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (DNA-directed RNA polymerase II 15.1 kDa polypeptide) RpII15 CG3284 Drosophila melanogaster (Fruit fly) TR20915_c0_g1_i1 A6NK53 ZN233_HUMAN 3.00E-06 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 233 ZNF233 Homo sapiens (Human) TR20916_c0_g1_i1 Q5ZJL9 SAMH1_CHICK 6.00E-28 GO:0003723; GO:0051607; GO:0045087; GO:0008152; GO:0046872; GO:0005634; GO:0008081; GO:0045088 RNA binding; defense response to virus; innate immune response; metabolic process; metal ion binding; nucleus; phosphoric diester hydrolase activity; regulation of innate immune response IPR003607; IPR006674; Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) SAMHD1 RCJMB04_17d8 Gallus gallus (Chicken) TR20936_c1_g1_i1 O15439 MRP4_HUMAN 6.00E-79 GO:0016404; GO:0005524; GO:0006200; GO:0042626; GO:0016021; GO:0005886; GO:0030168; GO:0002576; GO:0031088; GO:0055085 "15-hydroxyprostaglandin dehydrogenase (NAD+) activity; ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; plasma membrane; platelet activation; platelet degranulation; platelet dense granule membrane; transmembrane transport" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) ABCC4 MRP4 Homo sapiens (Human) TR20936_c5_g1_i1 Q9FVV9 NAP5_ARATH 1.00E-25 GO:0005524; GO:0042626; GO:0016021 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; integral to membrane" IPR011527; IPR003439; IPR027417; Probable non-intrinsic ABC protein 5 (MRP-related protein 2) NAP5 At1g71330 F3I17.2 Arabidopsis thaliana (Mouse-ear cress) TR20941_c0_g1_i1 P78524 ST5_HUMAN 5.00E-28 GO:0017112; GO:0070374 Rab guanyl-nucleotide exchange factor activity; positive regulation of ERK1 and ERK2 cascade IPR005112; IPR001194; IPR005113; Suppression of tumorigenicity 5 protein (DENN domain-containing protein 2B) (HeLa tumor suppression 1) ST5 DENND2B HTS1 Homo sapiens (Human) TR20941_c0_g2_i1 Q86WG5 MTMRD_HUMAN 1.00E-12 GO:0017112; GO:0016020; GO:0042552; GO:0016791; GO:0019208; GO:0035091; GO:0051262; GO:0005774 Rab guanyl-nucleotide exchange factor activity; membrane; myelination; phosphatase activity; phosphatase regulator activity; phosphatidylinositol binding; protein tetramerization; vacuolar membrane IPR005112; IPR001194; IPR004182; IPR010569; IPR017906; IPR011993; IPR001849; IPR022096; IPR005113; Myotubularin-related protein 13 (SET-binding factor 2) SBF2 CMT4B2 KIAA1766 MTMR13 Homo sapiens (Human) TR20944_c0_g1_i1 Q8VEM8 MPCP_MOUSE 1.00E-161 GO:0016021; GO:0005743; GO:0015293 integral to membrane; mitochondrial inner membrane; symporter activity IPR018108; IPR023395; "Phosphate carrier protein, mitochondrial (Phosphate transport protein) (PTP) (Solute carrier family 25 member 3)" Slc25a3 Mus musculus (Mouse) TR20945_c0_g1_i1 Q9JMD3 PCTL_MOUSE 5.00E-10 GO:0005929; GO:0005737; GO:0008289; GO:0006869; GO:0016020 cilium; cytoplasm; lipid binding; lipid transport; membrane IPR023393; IPR002913; PCTP-like protein (PCTP-L) (START domain-containing protein 10) (StARD10) (Serologically defined colon cancer antigen 28 homolog) (StAR-related lipid transfer protein 10) Stard10 Pctpl Sdccag28 Sdccagg28 Mus musculus (Mouse) TR20947_c3_g1_i1 P47237 PAX6_CHICK 3.00E-36 GO:0007275; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; Paired box protein Pax-6 (Fragment) PAX6 Gallus gallus (Chicken) TR20955_c0_g1_i1 Q8LFQ6 GRXC4_ARATH 6.00E-19 GO:0005794; GO:0045454; GO:0009055; GO:0005783; GO:0015035 Golgi apparatus; cell redox homeostasis; electron carrier activity; endoplasmic reticulum; protein disulfide oxidoreductase activity IPR011767; IPR002109; IPR011899; IPR014025; IPR012336; Glutaredoxin-C4 (AtGrxC4) GRXC4 GLU1 At5g20500 F7C8.90 Arabidopsis thaliana (Mouse-ear cress) TR20962_c4_g1_i1 Q11002 CANA_DROME 8.00E-08 GO:0021919; GO:0015629; GO:0005509; GO:0004198; GO:0042335; GO:0005737; GO:0008340; GO:0043025; GO:0006909; GO:0016540; GO:0006508 BMP signaling pathway involved in spinal cord dorsal/ventral patterning; actin cytoskeleton; calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cuticle development; cytoplasm; determination of adult lifespan; neuronal cell body; phagocytosis; protein autoprocessing; proteolysis IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-A (EC 3.4.22.-) (Calcium-activated neutral proteinase A) (CANP A) [Cleaved into: Calpain-A catalytic subunit] CalpA CG7563 Drosophila melanogaster (Fruit fly) TR20978_c0_g2_i1 Q4R7D5 F227B_MACFA 1.00E-46 Protein FAM227B FAM227B QtsA-15558 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR20979_c0_g1_i1 Q8NFP4 MDGA1_HUMAN 1.00E-21 GO:0046658; GO:0007420; GO:0001764; GO:0021527 anchored to plasma membrane; brain development; neuron migration; spinal cord association neuron differentiation IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3) MDGA1 MAMDC3 Homo sapiens (Human) TR20979_c0_g2_i1 Q0PMG2 MDGA1_MOUSE 2.00E-22 GO:0046658; GO:0021799; GO:0001764 anchored to plasma membrane; cerebral cortex radially oriented cell migration; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 Mdga1 Mus musculus (Mouse) TR20980_c0_g3_i1 Q5T197 DCST1_HUMAN 2.00E-14 GO:0016021; GO:0008270 integral to membrane; zinc ion binding IPR012858; IPR001841; DC-STAMP domain-containing protein 1 DCST1 Homo sapiens (Human) TR20981_c0_g1_i1 Q6NY73 L3BPB_DANRE 9.00E-16 GO:0007155; GO:0016020; GO:0005578; GO:0005044 cell adhesion; membrane; proteinaceous extracellular matrix; scavenger receptor activity IPR011705; IPR000210; IPR011333; IPR013069; IPR001190; IPR017448; Galectin-3-binding protein B (Lectin galactoside-binding soluble 3-binding protein B) lgals3bpb zgc:77059 Danio rerio (Zebrafish) (Brachydanio rerio) TR20983_c0_g1_i1 P0C0T0 LITAF_RAT 2.00E-17 GO:0005794; GO:0050699; GO:0007568; GO:0006915; GO:0005576; GO:0005765; GO:0005886; GO:0043123; GO:0006355; GO:0004871; GO:0006351 "Golgi apparatus; WW domain binding; aging; apoptotic process; extracellular region; lysosomal membrane; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of transcription, DNA-dependent; signal transducer activity; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Estrogen-enhanced transcript protein 1) (Eet-1) Litaf Rattus norvegicus (Rat) TR20984_c0_g1_i1 Q9J513 V222_FOWPN 3.00E-06 IPR002110; IPR020683; IPR018272; Putative ankyrin repeat protein FPV222 FPV222 Fowlpox virus (strain NVSL) (FPV) TR20984_c0_g1_i2 Q9VCA8 ANKHM_DROME 5.00E-10 GO:0003723; GO:0019730; GO:0051298; GO:0001751; GO:0005811; GO:0043066; GO:0046427; GO:0007169 RNA binding; antimicrobial humoral response; centrosome duplication; compound eye photoreceptor cell differentiation; lipid particle; negative regulation of apoptotic process; positive regulation of JAK-STAT cascade; transmembrane receptor protein tyrosine kinase signaling pathway IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) TR20987_c0_g2_i1 Q96RI1 NR1H4_HUMAN 4.00E-08 GO:0000980; GO:0003705; GO:0001190; GO:0008206; GO:0038181; GO:0071229; GO:1902122; GO:0048565; GO:0038185; GO:0004879; GO:0016922; GO:0070858; GO:0000122; GO:0001080; GO:0005719; GO:0005654; GO:0042277; GO:2001250; GO:2000213; GO:0006109; GO:0090181; GO:0034255; GO:0009749; GO:0032496; GO:0003707; GO:0004887; GO:0003713; GO:0003714; GO:0006367; GO:0008270 RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; bile acid metabolic process; bile acid receptor activity; cellular response to acid; chenodeoxycholic acid binding; digestive tract development; intracellular bile acid receptor signaling pathway; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; ligand-dependent nuclear receptor binding; negative regulation of bile acid biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; nitrogen catabolite activation of transcription from RNA polymerase II promoter; nuclear euchromatin; nucleoplasm; peptide binding; positive regulation of ammonia assimilation cycle; positive regulation of glutamate metabolic process; regulation of carbohydrate metabolic process; regulation of cholesterol metabolic process; regulation of urea metabolic process; response to glucose stimulus; response to lipopolysaccharide; steroid hormone receptor activity; thyroid hormone receptor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; zinc ion binding IPR008946; IPR000536; IPR001723; IPR001728; IPR001628; IPR013088; Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14) NR1H4 BAR FXR HRR1 RIP14 Homo sapiens (Human) TR20989_c0_g1_i1 Q963B7 RL9_SPOFR 2.00E-80 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR000702; IPR020040; IPR002359; 60S ribosomal protein L9 RpL9 Spodoptera frugiperda (Fall armyworm) TR20990_c0_g1_i1 P86854 PLCL_MYTGA 5.00E-13 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR20994_c0_g1_i1 Q9H015 S22A4_HUMAN 3.00E-08 GO:0005524; GO:0016324; GO:0007589; GO:0009437; GO:0015226; GO:0015491; GO:0005887; GO:0005739; GO:0000166; GO:0008513; GO:0006814; GO:0015293; GO:0006641 ATP binding; apical plasma membrane; body fluid secretion; carnitine metabolic process; carnitine transmembrane transporter activity; cation:cation antiporter activity; integral to plasma membrane; mitochondrion; nucleotide binding; secondary active organic cation transmembrane transporter activity; sodium ion transport; symporter activity; triglyceride metabolic process IPR020846; IPR016196; IPR004749; IPR005828; IPR005829; Solute carrier family 22 member 4 (Ergothioneine transporter) (ET transporter) (Organic cation/carnitine transporter 1) SLC22A4 ETT OCTN1 UT2H Homo sapiens (Human) TR20994_c1_g2_i1 Q4W8A2 S22A8_MACFA 4.00E-11 GO:0016323; GO:0016021; GO:0015075; GO:0009636 basolateral plasma membrane; integral to membrane; ion transmembrane transporter activity; response to toxic substance IPR020846; IPR016196; IPR004749; IPR005828; IPR005829; Solute carrier family 22 member 8 (Organic anion transporter 3) (mkOAT3) SLC22A8 OAT3 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR20997_c0_g1_i2 P32214 CALCR_RAT 9.00E-10 GO:0007188; GO:0030424; GO:0032841; GO:0004948; GO:0016021; GO:0043025; GO:0005886 adenylate cyclase-modulating G-protein coupled receptor signaling pathway; axon; calcitonin binding; calcitonin receptor activity; integral to membrane; neuronal cell body; plasma membrane IPR003287; IPR017981; IPR001688; IPR001879; IPR000832; IPR017983; Calcitonin receptor (CT-R) (C1A/C1B) Calcr Rattus norvegicus (Rat) TR20997_c1_g1_i1 P30988 CALCR_HUMAN 8.00E-37 GO:0007189; GO:0032841; GO:0004948; GO:0007204; GO:0005887; GO:0045762; GO:0072659; GO:0008565; GO:0004872; GO:0031623; GO:0051384 adenylate cyclase-activating G-protein coupled receptor signaling pathway; calcitonin binding; calcitonin receptor activity; elevation of cytosolic calcium ion concentration; integral to plasma membrane; positive regulation of adenylate cyclase activity; protein localization to plasma membrane; protein transporter activity; receptor activity; receptor internalization; response to glucocorticoid stimulus IPR003287; IPR017981; IPR001688; IPR001879; IPR000832; IPR017983; Calcitonin receptor (CT-R) CALCR Homo sapiens (Human) TR20997_c1_g1_i2 Q68EK2 CALRL_DANRE 9.00E-36 GO:0001525; GO:0048844; GO:0004948; GO:0016021; GO:0005886; GO:0001756 angiogenesis; artery morphogenesis; calcitonin receptor activity; integral to membrane; plasma membrane; somitogenesis IPR003287; IPR017981; IPR003289; IPR001879; IPR000832; IPR017983; Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) calcrla calcrl si:dkey-249o24.2 zgc:100872 Danio rerio (Zebrafish) (Brachydanio rerio) TR20999_c0_g1_i1 P06802 ENPP1_MOUSE 2.00E-19 GO:0035529; GO:0016323; GO:0031214; GO:0046849; GO:0009986; GO:0005615; GO:0006955; GO:0016021; GO:0046872; GO:0045599; GO:0030279; GO:0003676; GO:0004528; GO:0005886; GO:0030247; GO:0005044 NADH pyrophosphatase activity; basolateral plasma membrane; biomineral tissue development; bone remodeling; cell surface; extracellular space; immune response; integral to membrane; metal ion binding; negative regulation of fat cell differentiation; negative regulation of ossification; nucleic acid binding; phosphodiesterase I activity; plasma membrane; polysaccharide binding; scavenger receptor activity IPR017849; IPR017850; IPR001604; IPR024873; IPR020821; IPR002591; IPR020436; IPR001212; Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Lymphocyte antigen 41) (Ly-41) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9)] Enpp1 Npps Pc1 Pdnp1 Mus musculus (Mouse) TR210_c0_g1_i1 O43301 HS12A_HUMAN 1.00E-10 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR21000_c0_g2_i1 P41366 VMO1_CHICK 2.00E-09 GO:0005576; GO:0030704 extracellular region; vitelline membrane formation IPR005515; Vitelline membrane outer layer protein 1 (VMO-1) (VMO-I) (VMOI) VMO1 Gallus gallus (Chicken) TR21002_c0_g1_i1 Q5XWD5 IF_CANFA 5.00E-07 GO:0031419; GO:0009235; GO:0015889; GO:0006824; GO:0005576 cobalamin binding; cobalamin metabolic process; cobalamin transport; cobalt ion transport; extracellular region IPR002157; IPR027954; Gastric intrinsic factor (Intrinsic factor) (IF) (INF) (Pancreatic intrinsic factor) GIF Canis familiaris (Dog) (Canis lupus familiaris) TR21008_c1_g1_i1 Q9D0P0 EBPL_MOUSE 1.00E-67 GO:0047750; GO:0005789; GO:0016021; GO:0016125 cholestenol delta-isomerase activity; endoplasmic reticulum membrane; integral to membrane; sterol metabolic process IPR007905; Emopamil-binding protein-like (Emopamil-binding-related protein) Ebpl Ebrp Erp Mus musculus (Mouse) TR21018_c1_g1_i1 Q96JT2 S45A3_HUMAN 1.00E-15 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR016196; Solute carrier family 45 member 3 (Prostate cancer-associated protein 6) (Prostein) SLC45A3 PCANAP6 PRST Homo sapiens (Human) TR21018_c4_g1_i1 P58355 S45A2_MOUSE 3.00E-15 GO:0048066; GO:0016021; GO:0042438; GO:0033162; GO:0050896; GO:0007601 developmental pigmentation; integral to membrane; melanin biosynthetic process; melanosome membrane; response to stimulus; visual perception IPR016196; Membrane-associated transporter protein (Melanoma antigen AIM1) (Protein AIM-1) (Protein underwhite) (Solute carrier family 45 member 2) Slc45a2 Aim1 Matp uw Mus musculus (Mouse) TR21018_c5_g1_i1 Q39232 SUC1_ARATH 2.00E-08 GO:0005887; GO:0005886; GO:0009506; GO:0009846; GO:0009624; GO:0005985; GO:0008506; GO:0005773 integral to plasma membrane; plasma membrane; plasmodesma; pollen germination; response to nematode; sucrose metabolic process; sucrose:hydrogen symporter activity; vacuole IPR016196; IPR005828; IPR005989; Glycan biosynthesis; sucrose metabolism. Sucrose transport protein SUC1 (Sucrose permease 1) (Sucrose-proton symporter 1) SUC1 At1g71880 F17M19.3 Arabidopsis thaliana (Mouse-ear cress) TR21027_c0_g1_i1 C3YWU0 FUCO_BRAFL 8.00E-72 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR21031_c1_g1_i1 Q8TD20 GTR12_HUMAN 1.00E-15 GO:0012505; GO:0015758; GO:0016021; GO:0048471; GO:0005886; GO:0022891; GO:0055085 endomembrane system; glucose transport; integral to membrane; perinuclear region of cytoplasm; plasma membrane; substrate-specific transmembrane transporter activity; transmembrane transport IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 12 (Glucose transporter type 12) (GLUT-12)" SLC2A12 GLUT12 GLUT8 Homo sapiens (Human) TR21031_c1_g1_i2 Q8BFW9 GTR12_MOUSE 9.00E-16 GO:0012505; GO:0015758; GO:0016021; GO:0016020; GO:0022891 endomembrane system; glucose transport; integral to membrane; membrane; substrate-specific transmembrane transporter activity IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 12 (Glucose transporter type 12) (GLUT-12)" Slc2a12 Glut12 Glut8 Mus musculus (Mouse) TR21034_c0_g1_i1 Q9CQ69 QCR8_MOUSE 1.00E-26 GO:0021680; GO:0021766; GO:0021854; GO:0030901; GO:0005743; GO:0021548; GO:0021860; GO:0070469; GO:0021539; GO:0021794; GO:0008121 cerebellar Purkinje cell layer development; hippocampus development; hypothalamus development; midbrain development; mitochondrial inner membrane; pons development; pyramidal neuron development; respiratory chain; subthalamus development; thalamus development; ubiquinol-cytochrome-c reductase activity IPR004205; Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C) Uqcrq Mus musculus (Mouse) TR21036_c0_g1_i1 A6NK75 ZNF98_HUMAN 2.00E-17 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 98 (Zinc finger protein 739) (Zinc finger protein F7175) ZNF98 ZNF739 Homo sapiens (Human) TR21040_c3_g1_i1 Q84ME1 LUL3_ARATH 7.00E-06 GO:0004842; GO:0008270 ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase LUL3 (EC 6.3.2.-) (Protein LOG2-LIKE UBIQUITIN LIGASE 3) (RING finger protein 398) LUL3 RF398 At5g19080 T16G12.120 Arabidopsis thaliana (Mouse-ear cress) TR21041_c0_g1_i1 Q7ZVZ6 PREP_DANRE 5.00E-10 GO:0046872; GO:0004222; GO:0005759; GO:0006508 metal ion binding; metalloendopeptidase activity; mitochondrial matrix; proteolysis IPR011249; IPR011237; IPR011765; IPR007863; IPR013578; "Presequence protease, mitochondrial (EC 3.4.24.-) (Pitrilysin metalloproteinase 1)" pitrm1 zgc:55469 Danio rerio (Zebrafish) (Brachydanio rerio) TR21049_c1_g1_i1 Q5BKJ7 TOR4A_XENTR 3.00E-07 GO:0005524; GO:0051085; GO:0016021 ATP binding; chaperone mediated protein folding requiring cofactor; integral to membrane IPR001270; IPR027417; IPR010448; Torsin-4A (Torsin family 4 member A) tor4a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR21049_c1_g2_i1 Q95NU5 TORS_CAEEL 5.00E-15 GO:0005524; GO:0005818; GO:0071218; GO:0051085; GO:0005783; GO:0005788; GO:0017111; GO:0048471; GO:0005886; GO:0000922 ATP binding; aster; cellular response to misfolded protein; chaperone mediated protein folding requiring cofactor; endoplasmic reticulum; endoplasmic reticulum lumen; nucleoside-triphosphatase activity; perinuclear region of cytoplasm; plasma membrane; spindle pole IPR003593; IPR001270; IPR027417; IPR010448; IPR017378; Torsin-like protein (Abnormal oocyte formation protein 5) ooc-5 C18E9.11 Caenorhabditis elegans TR21050_c0_g1_i1 Q90YP3 RS28_ICTPU 2.00E-26 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR012340; IPR000289; 40S ribosomal protein S28 rps28 Ictalurus punctatus (Channel catfish) (Silurus punctatus) TR21052_c0_g1_i1 Q8NBH2 KY_HUMAN 1.00E-16 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) KY Homo sapiens (Human) TR21059_c0_g1_i1 P98074 ENTK_PIG 5.00E-11 GO:0016021; GO:0006508; GO:0005044; GO:0004252 integral to membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity IPR008985; IPR000859; IPR023415; IPR002172; IPR000998; IPR011163; IPR001254; IPR018114; IPR001314; IPR000082; IPR001190; IPR017448; IPR009003; Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic mini chain; Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain] TMPRSS15 ENTK PRSS7 Sus scrofa (Pig) TR21065_c0_g1_i1 Q3UHG7 LCHN_MOUSE 7.00E-148 IPR018626; Protein LCHN Lchn Kiaa1147 Mus musculus (Mouse) TR21067_c0_g1_i1 Q8BRH0 TMTC3_MOUSE 2.00E-27 GO:0060447; GO:0016021; GO:0048286; GO:0048747; GO:0009791; GO:0010468 bud outgrowth involved in lung branching; integral to membrane; lung alveolus development; muscle fiber development; post-embryonic development; regulation of gene expression IPR013618; IPR013026; IPR011990; IPR019734; Transmembrane and TPR repeat-containing protein 3 Tmtc3 Mus musculus (Mouse) TR21067_c0_g2_i1 Q8BG19 TMTC4_MOUSE 6.00E-42 GO:0016021 integral to membrane IPR013618; IPR013026; IPR011990; IPR019734; Transmembrane and TPR repeat-containing protein 4 Tmtc4 Mus musculus (Mouse) TR21068_c0_g1_i1 O00625 PIR_HUMAN 9.00E-124 GO:0005737; GO:0046872; GO:0030224; GO:0005634; GO:0008127; GO:0006355; GO:0003712; GO:0006366 "cytoplasm; metal ion binding; monocyte differentiation; nucleus; quercetin 2,3-dioxygenase activity; regulation of transcription, DNA-dependent; transcription cofactor activity; transcription from RNA polymerase II promoter" IPR012093; IPR008778; IPR003829; IPR014710; IPR011051; Flavonoid metabolism; quercetin degradation. "Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase)" PIR Homo sapiens (Human) TR21069_c0_g2_i1 Q3MII6 TBC25_HUMAN 2.00E-13 GO:0005097; GO:0005776; GO:0006914; GO:0031410; GO:1901096 Rab GTPase activator activity; autophagic vacuole; autophagy; cytoplasmic vesicle; regulation of autophagic vacuole maturation IPR000195; TBC1 domain family member 25 TBC1D25 OATL1 Homo sapiens (Human) TR21079_c0_g2_i1 P14381 YTX2_XENLA 5.00E-11 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR21082_c0_g1_i1 P13590 NCAM1_CHICK 3.00E-08 GO:0007155; GO:0016021; GO:0005886 cell adhesion; integral to membrane; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR009138; Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) NCAM1 Gallus gallus (Chicken) TR21084_c0_g1_i1 P22031 LEG_ANTCR 2.00E-07 GO:0030246; GO:0005737 carbohydrate binding; cytoplasm IPR000922; D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL) Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR21086_c0_g1_i1 Q5ND28 SREC_MOUSE 5.00E-06 GO:0007155; GO:0016358; GO:0016021; GO:0030169; GO:0016322; GO:0005886; GO:0048680; GO:0005044 cell adhesion; dendrite development; integral to membrane; low-density lipoprotein particle binding; neuron remodeling; plasma membrane; positive regulation of axon regeneration; scavenger receptor activity IPR000742; IPR013032; IPR002049; IPR009030; Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) TR2109_c0_g1_i1 P12613 TCPA_DROME 2.00E-14 GO:0005524; GO:0008553; GO:0005875; GO:0005753; GO:0007052; GO:0006909; GO:0006457 "ATP binding; hydrogen-exporting ATPase activity, phosphorylative mechanism; microtubule associated complex; mitochondrial proton-transporting ATP synthase complex; mitotic spindle organization; phagocytosis; protein folding" IPR012715; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) T-cp1 CCT-1 Tcp-1 CG5374 Drosophila melanogaster (Fruit fly) TR21090_c3_g1_i1 P09884 DPOLA_HUMAN 8.00E-49 GO:0008408; GO:0051539; GO:0003677; GO:0006270; GO:0006269; GO:0003887; GO:0005658; GO:0008283; GO:0003682; GO:0005737; GO:0006303; GO:0006273; GO:0006272; GO:0046872; GO:0000084; GO:0019048; GO:0005635; GO:0016363; GO:0005730; GO:0005654; GO:0001882; GO:0000166; GO:0000083; GO:0000722; GO:0032201; GO:0019985 P03070; P04014; P27694; P10193 "3'-5' exonuclease activity; 4 iron, 4 sulfur cluster binding; DNA binding; DNA replication initiation; DNA replication, synthesis of RNA primer; DNA-directed DNA polymerase activity; alpha DNA polymerase:primase complex; cell proliferation; chromatin binding; cytoplasm; double-strand break repair via nonhomologous end joining; lagging strand elongation; leading strand elongation; metal ion binding; mitotic S phase; modulation by virus of host morphology or physiology; nuclear envelope; nuclear matrix; nucleolus; nucleoplasm; nucleoside binding; nucleotide binding; regulation of transcription involved in G1/S transition of mitotic cell cycle; telomere maintenance via recombination; telomere maintenance via semi-conservative replication; translesion synthesis" IPR006172; IPR017964; IPR006133; IPR006134; IPR004578; IPR024647; IPR023211; IPR012337; IPR015088; DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) POLA1 POLA Homo sapiens (Human) TR21092_c1_g1_i2 Q5T6V5 CI064_HUMAN 1.00E-111 IPR019438; UPF0553 protein C9orf64 C9orf64 Homo sapiens (Human) TR21095_c0_g1_i1 Q1L8G6 AKIB1_DANRE 1.00E-20 GO:0008270 zinc ion binding IPR002110; IPR020683; IPR003903; IPR002867; IPR001841; IPR013083; Ankyrin repeat and IBR domain-containing protein 1 ankib1 si:dkey-231l1.6 Danio rerio (Zebrafish) (Brachydanio rerio) TR21096_c0_g1_i1 O12947 ICMT_XENLA 1.00E-84 GO:0005789; GO:0016021; GO:0004671 endoplasmic reticulum membrane; integral to membrane; protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IPR007269; IPR025770; Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) (Farnesyl cysteine carboxyl methyltransferase) (FCMT) (Isoprenylcysteine carboxylmethyltransferase) (Prenylated protein carboxyl methyltransferase) (PPMT) (Prenylcysteine carboxyl methyltransferase) (pcCMT) icmt Xenopus laevis (African clawed frog) TR21115_c0_g1_i1 Q9Y394 DHRS7_HUMAN 1.00E-23 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Dehydrogenase/reductase SDR family member 7 (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) DHRS7 DHRS7A RETSDR4 CGI-86 UNQ285/PRO3448 Homo sapiens (Human) TR21116_c0_g1_i1 Q9Y5J7 TIM9_HUMAN 7.00E-27 GO:0044267; GO:0072321; GO:0005743; GO:0042719; GO:0045039; GO:0007605; GO:0005215; GO:0008270 P62072 cellular protein metabolic process; chaperone-mediated protein transport; mitochondrial inner membrane; mitochondrial intermembrane space protein transporter complex; protein import into mitochondrial inner membrane; sensory perception of sound; transporter activity; zinc ion binding IPR004217; Mitochondrial import inner membrane translocase subunit Tim9 TIMM9 TIM9 TIM9A TIMM9A Homo sapiens (Human) TR21121_c1_g1_i1 Q7M3S9 RNGB_DICDI 1.00E-06 GO:0005737; GO:0008270 cytoplasm; zinc ion binding IPR015915; IPR006652; IPR001841; IPR013083; RING finger protein B (Protein rngB) rngB DDB_G0268860 Dictyostelium discoideum (Slime mold) TR21121_c1_g2_i1 Q6R7I2 IAP1_OSHVF 1.00E-07 GO:0008270 zinc ion binding IPR001370; IPR001841; IPR013083; Putative apoptosis inhibitor ORF42 ORF42 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) TR21121_c1_g3_i1 Q8BVR6 RSPRY_MOUSE 2.00E-34 GO:0005576; GO:0008270 extracellular region; zinc ion binding IPR016024; IPR001870; IPR008985; IPR018355; IPR003877; IPR001841; IPR013083; RING finger and SPRY domain-containing protein 1 Rspry1 Kiaa1972 Mus musculus (Mouse) TR21121_c3_g1_i1 Q5XPI3 RN123_MOUSE 3.00E-11 GO:0005737; GO:0016874; GO:0016567; GO:0008270 cytoplasm; ligase activity; protein ubiquitination; zinc ion binding IPR001870; IPR008985; IPR018355; IPR003877; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF123 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) Rnf123 Kpc1 Mus musculus (Mouse) TR21122_c3_g1_i1 Q6DFV8 VWDE_MOUSE 2.00E-08 GO:0005576 extracellular region IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) TR21125_c2_g1_i1 P83941 ELOC_RAT 4.00E-50 GO:0030891; GO:0005634; GO:0032968; GO:0006351; GO:0006511 "VCB complex; nucleus; positive regulation of transcription elongation from RNA polymerase II promoter; transcription, DNA-dependent; ubiquitin-dependent protein catabolic process" IPR011333; IPR001232; IPR016073; Transcription elongation factor B polypeptide 1 (Elongin 15 kDa subunit) (Elongin-C) (EloC) (RNA polymerase II transcription factor SIII subunit C) (SIII p15) (Stromal membrane-associated protein SMAP1B homolog) Tceb1 Rattus norvegicus (Rat) TR21129_c2_g1_i1 Q3V0B4 CC108_MOUSE 1.00E-35 GO:0016021 integral to membrane Coiled-coil domain-containing protein 108 Ccdc108 Mus musculus (Mouse) TR21132_c0_g1_i1 O23320 CML8_ARATH 3.00E-09 GO:0005509; GO:0019722; GO:0005513 calcium ion binding; calcium-mediated signaling; detection of calcium ion IPR011992; IPR018247; IPR002048; Calmodulin-like protein 8 (AtCaM-8) CML8 CAM8 At4g14640 dl3360w FCAALL.157 Arabidopsis thaliana (Mouse-ear cress) TR21132_c0_g1_i2 P24044 CALM_PLAFA 6.00E-10 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) Plasmodium falciparum TR21133_c0_g2_i1 O94919 ENDD1_HUMAN 6.00E-19 GO:0004519; GO:0005576; GO:0046872; GO:0003676; GO:0090305 endonuclease activity; extracellular region; metal ion binding; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis IPR001604; IPR020821; Endonuclease domain-containing 1 protein (EC 3.1.30.-) ENDOD1 KIAA0830 Homo sapiens (Human) TR21134_c1_g1_i1 P61315 G3ST3_MOUSE 1.00E-14 GO:0032580; GO:0009058; GO:0001733; GO:0016021 Golgi cisterna membrane; biosynthetic process; galactosylceramide sulfotransferase activity; integral to membrane IPR009729; IPR027417; Protein modification; carbohydrate sulfation. "Galactose-3-O-sulfotransferase 3 (Gal3ST-3) (EC 2.8.2.-) (Beta-galactose-3-O-sulfotransferase 3) (Gal-beta-1, 3-GalNAc 3'-sulfotransferase 3)" Gal3st3 Mus musculus (Mouse) TR21139_c0_g1_i1 P17213 BPI_HUMAN 3.00E-10 GO:0005737; GO:0042742; GO:0005576; GO:0006955; GO:0005887; GO:0001530; GO:0032715; GO:0032717; GO:0043031; GO:0032720 cytoplasm; defense response to bacterium; extracellular region; immune response; integral to plasma membrane; lipopolysaccharide binding; negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; negative regulation of macrophage activation; negative regulation of tumor necrosis factor production IPR017943; IPR001124; IPR017954; IPR017942; Bactericidal permeability-increasing protein (BPI) (CAP 57) BPI Homo sapiens (Human) TR21139_c1_g1_i1 Q28739 BPI_RABIT 5.00E-08 GO:0042742; GO:0005576; GO:0008289; GO:0016020 defense response to bacterium; extracellular region; lipid binding; membrane IPR017943; IPR001124; IPR017942; Bactericidal permeability-increasing protein (BPI) (Fragment) BPI Oryctolagus cuniculus (Rabbit) TR21140_c1_g1_i1 Q9XUB2 MEX5_CAEEL 3.00E-11 GO:0003677; GO:0043186; GO:0005813; GO:0003730; GO:0046872; GO:0007275; GO:0008187; GO:0032880 DNA binding; P granule; centrosome; mRNA 3'-UTR binding; metal ion binding; multicellular organismal development; poly-pyrimidine tract binding; regulation of protein localization IPR000571; Zinc finger protein mex-5 mex-5 W02A2.7 Caenorhabditis elegans TR21140_c1_g2_i1 Q07352 TISB_HUMAN 2.00E-42 GO:0003677; GO:0033077; GO:0005829; GO:0010467; GO:0003729; GO:0016071; GO:0046872; GO:0000288; GO:0005634; GO:0043488; GO:0006417; GO:0003700; GO:0001570 Q16539 "DNA binding; T cell differentiation in thymus; cytosol; gene expression; mRNA binding; mRNA metabolic process; metal ion binding; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; nucleus; regulation of mRNA stability; regulation of translation; sequence-specific DNA binding transcription factor activity; vasculogenesis" IPR007635; IPR000571; "Zinc finger protein 36, C3H1 type-like 1 (Butyrate response factor 1) (EGF-response factor 1) (ERF-1) (Protein TIS11B)" ZFP36L1 BERG36 BRF1 ERF1 RNF162B TIS11B Homo sapiens (Human) TR21152_c1_g1_i1 P05363 NK2R_BOVIN 2.00E-19 GO:0016021; GO:0005886; GO:0004995; GO:0007217 integral to membrane; plasma membrane; tachykinin receptor activity; tachykinin receptor signaling pathway IPR000276; IPR017452; IPR001681; IPR000913; Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2) TACR2 TAC2R Bos taurus (Bovine) TR21152_c1_g2_i1 P25931 NPYR_DROME 1.00E-32 GO:0016021; GO:0004983; GO:0008188; GO:0005886 integral to membrane; neuropeptide Y receptor activity; neuropeptide receptor activity; plasma membrane IPR000276; IPR017452; IPR000611; Neuropeptide Y receptor (NPY-R) (PR4 receptor) NepYr CG5811 Drosophila melanogaster (Fruit fly) TR21152_c1_g4_i1 Q9EP86 NPFF1_RAT 2.00E-26 GO:0016021; GO:0008188; GO:0007218; GO:0005886 integral to membrane; neuropeptide receptor activity; neuropeptide signaling pathway; plasma membrane IPR000276; IPR017452; IPR005395; IPR005396; Neuropeptide FF receptor 1 (G-protein coupled receptor 147) (RFamide-related peptide receptor OT7T022) Npffr1 Gpr147 Npff1 Rattus norvegicus (Rat) TR21160_c0_g1_i1 Q1LZ75 ERCC1_BOVIN 1.00E-101 GO:0009650; GO:0008283; GO:0051276; GO:0003684; GO:0006302; GO:0004519; GO:0007281; GO:0045190; GO:0008584; GO:0006312; GO:0035264; GO:0010259; GO:0043066; GO:0032205; GO:0000784; GO:0000109; GO:0006295; GO:0006296; GO:0048477; GO:0035166; GO:0008022; GO:0000720; GO:0001302; GO:0010165; GO:0006979; GO:0003697; GO:0007283; GO:0006949; GO:0005669 "UV protection; cell proliferation; chromosome organization; damaged DNA binding; double-strand break repair; endonuclease activity; germ cell development; isotype switching; male gonad development; mitotic recombination; multicellular organism growth; multicellular organismal aging; negative regulation of apoptotic process; negative regulation of telomere maintenance; nuclear chromosome, telomeric region; nucleotide-excision repair complex; nucleotide-excision repair, DNA incision, 3'-to lesion; nucleotide-excision repair, DNA incision, 5'-to lesion; oogenesis; post-embryonic hemopoiesis; protein C-terminus binding; pyrimidine dimer repair by nucleotide-excision repair; replicative cell aging; response to X-ray; response to oxidative stress; single-stranded DNA binding; spermatogenesis; syncytium formation; transcription factor TFIID complex" IPR004579; IPR003583; IPR011335; IPR010994; DNA excision repair protein ERCC-1 ERCC1 Bos taurus (Bovine) TR21160_c0_g2_i1 Q9D773 RM02_MOUSE 4.00E-41 GO:0005762; GO:0003735; GO:0006412 mitochondrial large ribosomal subunit; structural constituent of ribosome; translation IPR012340; IPR022666; IPR014722; IPR002171; IPR022669; IPR014726; IPR008991; "39S ribosomal protein L2, mitochondrial (L2mt) (MRP-L2)" Mrpl2 Mus musculus (Mouse) TR21167_c1_g1_i1 Q8TF62 AT8B4_HUMAN 1.00E-65 GO:0005524; GO:0019829; GO:0016021; GO:0000287; GO:0004012 ATP binding; cation-transporting ATPase activity; integral to membrane; magnesium ion binding; phospholipid-translocating ATPase activity IPR023299; IPR018303; IPR006539; IPR008250; IPR001757; IPR023214; Probable phospholipid-transporting ATPase IM (EC 3.6.3.1) (ATPase class I type 8B member 4) ATP8B4 KIAA1939 Homo sapiens (Human) TR21174_c0_g1_i2 Q81CK1 KYNB_BACCR 4.00E-11 GO:0043420; GO:0004061; GO:0004328; GO:0019441 anthranilate metabolic process; arylformamidase activity; formamidase activity; tryptophan catabolic process to kynurenine IPR007325; IPR017484; Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. Kynurenine formamidase (KFA) (KFase) (EC 3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF) kynB BC_2758 Bacillus cereus (strain ATCC 14579 / DSM 31) TR21177_c0_g1_i1 Q8K0Q5 RHG18_MOUSE 5.00E-11 GO:0005096; GO:0005622; GO:0043547; GO:0007165 GTPase activator activity; intracellular; positive regulation of GTPase activity; signal transduction IPR008936; IPR000198; Rho GTPase-activating protein 18 (Rho-type GTPase-activating protein 18) Arhgap18 Mus musculus (Mouse) TR21178_c2_g1_i1 Q6P0D7 MPP7_DANRE 1.00E-41 GO:0005912; GO:0016020; GO:0005923 adherens junction; membrane; tight junction IPR008145; IPR008144; IPR020590; IPR004172; IPR014775; IPR027417; IPR001478; IPR011511; IPR001452; MAGUK p55 subfamily member 7 (Protein humpback) mpp7 dlg3 hmp Danio rerio (Zebrafish) (Brachydanio rerio) TR21180_c0_g2_i1 P37837 TALDO_HUMAN 2.00E-94 GO:0005829; GO:0006112; GO:0006098; GO:0004801; GO:0005999 cytosol; energy reserve metabolic process; pentose-phosphate shunt; sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity; xylulose biosynthetic process IPR013785; IPR001585; IPR004730; IPR018225; Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3. Transaldolase (EC 2.2.1.2) TALDO1 TAL TALDO TALDOR Homo sapiens (Human) TR21183_c0_g1_i1 Q93104 ERH_AEDAE 9.00E-29 GO:0007049 cell cycle IPR000781; Enhancer of rudimentary homolog Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR21206_c1_g1_i1 Q9NQQ7 S35C2_HUMAN 3.00E-76 GO:0005801; GO:0005793; GO:0016021; GO:0010629; GO:0045747; GO:0036066; GO:0006810 cis-Golgi network; endoplasmic reticulum-Golgi intermediate compartment; integral to membrane; negative regulation of gene expression; positive regulation of Notch signaling pathway; protein O-linked fucosylation; transport IPR004853; Solute carrier family 35 member C2 (Ovarian cancer-overexpressed gene 1 protein) SLC35C2 C20orf5 OVCOV1 CGI-15 Homo sapiens (Human) TR21213_c1_g1_i1 O55737 123R_IIV6 1.00E-12 GO:0035335; GO:0004725; GO:0008138 peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Putative tyrosine phosphatase 123R (EC 3.1.3.-) IIV6-123R Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) TR21213_c2_g1_i1 Q05922 DUS2_MOUSE 4.00E-33 GO:0017017; GO:0001706; GO:0005654; GO:0035335; GO:0004725; GO:0042981 P28482 MAP kinase tyrosine/serine/threonine phosphatase activity; endoderm formation; nucleoplasm; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; regulation of apoptotic process IPR020417; IPR000340; IPR020422; IPR024950; IPR008343; IPR001763; IPR000387; IPR016130; Dual specificity protein phosphatase 2 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PAC-1) Dusp2 Pac-1 Pac1 Mus musculus (Mouse) TR21214_c1_g2_i1 A1AV12 HLDE_PELPD 1.00E-15 GO:0097171; GO:0005524; GO:0033785; GO:0033786; GO:0016773 "ADP-L-glycero-beta-D-manno-heptose biosynthetic process; ATP binding; heptose 7-phosphate kinase activity; heptose-1-phosphate adenylyltransferase activity; phosphotransferase activity, alcohol group as acceptor" IPR023030; IPR004821; IPR011611; IPR011913; IPR011914; IPR014729; Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4. Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4. Bifunctional protein HldE [Includes: D-beta-D-heptose 7-phosphate kinase (EC 2.7.1.167) (D-beta-D-heptose 7-phosphotransferase) (D-glycero-beta-D-manno-heptose-7-phosphate kinase); D-beta-D-heptose 1-phosphate adenylyltransferase (EC 2.7.7.70) (D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase)] hldE Ppro_3591 Pelobacter propionicus (strain DSM 2379) TR21224_c0_g1_i1 Q6AW46 EST5A_MOUSE 2.00E-16 GO:0004091; GO:0005576 carboxylesterase activity; extracellular region IPR002018; IPR019826; IPR019819; Carboxylesterase 5A (EC 3.1.1.1) (Carboxylesterase-like urinary excreted protein homolog) (Cauxin) Ces5a Ces7 Mus musculus (Mouse) TR21226_c0_g1_i1 Q0EEE2 PTHD3_MOUSE 1.00E-28 GO:0008158; GO:0016021 hedgehog receptor activity; integral to membrane IPR003392; IPR000731; Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) TR21226_c4_g1_i1 Q0EEE2 PTHD3_MOUSE 1.00E-25 GO:0008158; GO:0016021 hedgehog receptor activity; integral to membrane IPR003392; IPR000731; Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) TR21230_c0_g1_i1 P43143 ACHA6_RAT 8.00E-27 GO:0004889; GO:0005892; GO:0030054; GO:0008144; GO:0045211; GO:0051291 acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; drug binding; postsynaptic membrane; protein heterooligomerization IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Acra6 Rattus norvegicus (Rat) TR21232_c1_g1_i1 Q63HN8 RN213_HUMAN 3.00E-18 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR018957; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) TR21233_c0_g1_i3 Q8K0U4 HS12A_MOUSE 4.00E-51 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR21236_c0_g1_i1 Q90660 BIR_CHICK 5.00E-11 GO:0006915; GO:0005737; GO:0043066; GO:0005634; GO:0008270 apoptotic process; cytoplasm; negative regulation of apoptotic process; nucleus; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Inhibitor of apoptosis protein (IAP) (Inhibitor of T-cell apoptosis protein) ITA IAP1 Gallus gallus (Chicken) TR21237_c1_g1_i1 Q9Y5Q9 TF3C3_HUMAN 1.00E-54 GO:0042791; GO:0003677; GO:0005654; GO:0042797; GO:0000127 5S class rRNA transcription from RNA polymerase III type 1 promoter; DNA binding; nucleoplasm; tRNA transcription from RNA polymerase III promoter; transcription factor TFIIIC complex IPR013026; IPR011990; IPR001440; IPR019734; General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) GTF3C3 Homo sapiens (Human) TR21242_c0_g1_i1 Q64319 SLC31_RAT 2.00E-88 GO:0006865; GO:0005975; GO:0003824; GO:0043169; GO:0005887; GO:0046982; GO:0005774 amino acid transport; carbohydrate metabolic process; catalytic activity; cation binding; integral to plasma membrane; protein heterodimerization activity; vacuolar membrane IPR015902; IPR006047; IPR006589; IPR013781; IPR017853; "Neutral and basic amino acid transport protein rBAT (B(0,+)-type amino acid transport protein) (NAA-TR) (D2) (Solute carrier family 3 member 1)" Slc3a1 Nbat Rattus norvegicus (Rat) TR21249_c2_g1_i1 Q25413 MYOM_LYMST 6.00E-07 GO:0005576; GO:0007218 extracellular region; neuropeptide signaling pathway Myomodulin neuropeptides [Cleaved into: GLQMLRL-amide; QIPMLRL-amide; SMSMLRL-amide; SLSMLRL-amide; Myomodulin-A (PMSMLRL-amide)] Lymnaea stagnalis (Great pond snail) TR21258_c2_g1_i2 Q9NX78 CN101_HUMAN 4.00E-28 GO:0016021 integral to membrane IPR021280; Transmembrane protein 260 TMEM260 C14orf101 Homo sapiens (Human) TR21260_c1_g1_i1 Q8VIJ8 NPRL3_MOUSE 2.00E-21 GO:0005096; GO:0035909; GO:0048738; GO:0060021; GO:0043547; GO:0003281 GTPase activator activity; aorta morphogenesis; cardiac muscle tissue development; palate development; positive regulation of GTPase activity; ventricular septum development IPR008979; IPR005365; Nitrogen permease regulator 3-like protein (Alpha-globin regulatory element-containing gene protein) Nprl3 Mare Mus musculus (Mouse) TR21260_c2_g1_i1 Q12980 NPRL3_HUMAN 1.00E-38 GO:0005096; GO:0043547 Q8WTW4 GTPase activator activity; positive regulation of GTPase activity IPR005365; Nitrogen permease regulator 3-like protein (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Protein CGTHBA) NPRL3 C16orf35 CGTHBA MARE Homo sapiens (Human) TR21265_c0_g2_i1 Q17GM7 CISY1_AEDAE 3.00E-09 GO:0005975; GO:0044262; GO:0004108; GO:0005759; GO:0006099 carbohydrate metabolic process; cellular carbohydrate metabolic process; citrate (Si)-synthase activity; mitochondrial matrix; tricarboxylic acid cycle IPR016142; IPR002020; IPR016141; IPR019810; IPR010109; Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2. "Probable citrate synthase 1, mitochondrial (EC 2.3.3.1)" AAEL002956 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR21273_c1_g1_i1 Q09927 AZET_SCHPO 2.00E-24 GO:0006526; GO:0046941; GO:0034599; GO:0005829; GO:0005634; GO:0006562 arginine biosynthetic process; azetidine-2-carboxylic acid acetyltransferase activity; cellular response to oxidative stress; cytosol; nucleus; proline catabolic process IPR016181; IPR000182; L-azetidine-2-carboxylic acid acetyltransferase (EC 2.3.1.-) ppr1 SPAC21E11.04 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR21275_c0_g1_i1 P08548 LIN1_NYCCO 1.00E-07 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR21277_c2_g1_i1 Q8IYB1 M21D2_HUMAN 4.00E-09 IPR024810; IPR024803; Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) TR21278_c0_g1_i1 Q5RG45 CP135_DANRE 5.00E-26 GO:0005814; GO:0007099; GO:0010457 centriole; centriole replication; centriole-centriole cohesion IPR026732; Centrosomal protein of 135 kDa (Cep135) cep135 si:dkeyp-117h8.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR21280_c1_g1_i1 O94431 YHKC_SCHPO 5.00E-26 GO:0005829; GO:0005634; GO:0030170; GO:0008483 cytosol; nucleus; pyridoxal phosphate binding; transaminase activity IPR000192; IPR015424; IPR015421; Uncharacterized aminotransferase C660.12c (EC 2.6.-.-) SPBC660.12c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR21280_c1_g2_i1 O94431 YHKC_SCHPO 3.00E-19 GO:0005829; GO:0005634; GO:0030170; GO:0008483 cytosol; nucleus; pyridoxal phosphate binding; transaminase activity IPR000192; IPR015424; IPR015421; Uncharacterized aminotransferase C660.12c (EC 2.6.-.-) SPBC660.12c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR21283_c1_g1_i1 Q09298 PINK1_CAEEL 1.00E-14 GO:0005524; GO:0048846; GO:0034599; GO:0046872; GO:0005739; GO:0007005; GO:0004674; GO:0034976 ATP binding; axon extension involved in axon guidance; cellular response to oxidative stress; metal ion binding; mitochondrion; mitochondrion organization; protein serine/threonine kinase activity; response to endoplasmic reticulum stress IPR011009; IPR000719; "Serine/threonine-protein kinase pink-1, mitochondrial (EC 2.7.11.1) (PTEN-induced kinase 1 homolog)" pink-1 EEED8.9 Caenorhabditis elegans TR21283_c2_g1_i1 Q99MQ3 PINK1_MOUSE 1.00E-23 GO:0005524; GO:0010857; GO:0097237; GO:0005829; GO:0016021; GO:0007243; GO:0000287; GO:0005741; GO:0005739; GO:0000422; GO:0043524; GO:0018105; GO:0043123; GO:0033603; GO:0090200; GO:0032226; GO:0004674; GO:0043254; GO:0031396; GO:0006950 "ATP binding; calcium-dependent protein kinase activity; cellular response to toxic substance; cytosol; integral to membrane; intracellular protein kinase cascade; magnesium ion binding; mitochondrial outer membrane; mitochondrion; mitochondrion degradation; negative regulation of neuron apoptotic process; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of dopamine secretion; positive regulation of release of cytochrome c from mitochondria; positive regulation of synaptic transmission, dopaminergic; protein serine/threonine kinase activity; regulation of protein complex assembly; regulation of protein ubiquitination; response to stress" IPR011009; IPR000719; IPR017441; IPR008271; "Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)" Pink1 Mus musculus (Mouse) TR21293_c0_g2_i1 Q9D2J7 ANKR5_MOUSE 8.00E-24 GO:0005509 calcium ion binding IPR002110; IPR020683; IPR011992; Ankyrin repeat and EF-hand domain-containing protein 1 (Ankyrin repeat domain-containing protein 5) Ankef1 Ankrd5 Mus musculus (Mouse) TR21298_c2_g1_i1 F1NTD6 ASCC3_CHICK 4.00E-171 GO:0005524; GO:0043140; GO:0006307; GO:0008283; GO:0005737; GO:0003676; GO:0005634; GO:0006355; GO:0006351 "ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA dealkylation involved in DNA repair; cell proliferation; cytoplasm; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003593; IPR011545; IPR014001; IPR001650; IPR014756; IPR027417; IPR004179; Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) ascc3 Gallus gallus (Chicken) TR21300_c0_g1_i1 O88279 SLIT1_RAT 2.00E-28 GO:0048846; GO:0007420; GO:0005509; GO:0005737; GO:0033563; GO:0040023; GO:0005615; GO:0043395; GO:0008045; GO:0050919; GO:0048843; GO:0051964; GO:0031290; GO:0021510; GO:0022028 axon extension involved in axon guidance; brain development; calcium ion binding; cytoplasm; dorsal/ventral axon guidance; establishment of nucleus localization; extracellular space; heparan sulfate proteoglycan binding; motor neuron axon guidance; negative chemotaxis; negative regulation of axon extension involved in axon guidance; negative regulation of synapse assembly; retinal ganglion cell axon guidance; spinal cord development; tangential migration from the subventricular zone to the olfactory bulb IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4) Slit1 Megf4 Rattus norvegicus (Rat) TR21313_c1_g1_i1 P11240 COX5A_RAT 4.00E-45 GO:0004129; GO:0046872; GO:0005743 cytochrome-c oxidase activity; metal ion binding; mitochondrial inner membrane IPR003204; "Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va)" Cox5a Rattus norvegicus (Rat) TR21319_c1_g1_i1 A6NK53 ZN233_HUMAN 7.00E-27 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 233 ZNF233 Homo sapiens (Human) TR21320_c1_g1_i1 Q08D64 ABCB6_XENTR 1.00E-47 GO:0005524; GO:0006200; GO:0042626; GO:0005794; GO:0005783; GO:0016021; GO:0005741; GO:0005886 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; Golgi apparatus; endoplasmic reticulum; integral to membrane; mitochondrial outer membrane; plasma membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; "ATP-binding cassette sub-family B member 6, mitochondrial" abcb6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR21323_c0_g1_i1 Q7T3E5 KAT3_DANRE 2.00E-60 GO:0009058; GO:0047804; GO:0047315; GO:0016212; GO:0030170 biosynthetic process; cysteine-S-conjugate beta-lyase activity; kynurenine-glyoxylate transaminase activity; kynurenine-oxoglutarate transaminase activity; pyridoxal phosphate binding IPR004839; IPR015424; IPR015421; IPR015422; Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III) ccbl2 kat3 zgc:63929 Danio rerio (Zebrafish) (Brachydanio rerio) TR21341_c0_g1_i1 Q3ZBF0 NADE_BOVIN 1.00E-75 GO:0005524; GO:0009435; GO:0003952; GO:0016810 "ATP binding; NAD biosynthetic process; NAD+ synthase (glutamine-hydrolyzing) activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds" IPR003010; IPR014445; IPR022310; IPR003694; IPR014729; Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1. Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) (NAD(+) synthetase) NADSYN1 Bos taurus (Bovine) TR21342_c0_g1_i1 Q8R151 ZNFX1_MOUSE 4.00E-17 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR21347_c4_g1_i1 P33527 MRP1_HUMAN 9.00E-39 GO:0005524; GO:0042626; GO:0005794; GO:0019369; GO:0009235; GO:0005887; GO:0006691; GO:0005634; GO:0042493 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; Golgi apparatus; arachidonic acid metabolic process; cobalamin metabolic process; integral to plasma membrane; leukotriene metabolic process; nucleus; response to drug" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP MRP1 Homo sapiens (Human) TR21352_c0_g1_i1 B2RYN7 SPAST_RAT 7.00E-76 GO:0005524; GO:0006888; GO:0043014; GO:0007409; GO:0048487; GO:0005813; GO:0007109; GO:0031410; GO:0005783; GO:0005768; GO:0016021; GO:0005874; GO:0008017; GO:0001578; GO:0051013; GO:0008568; GO:0030496; GO:0005634; GO:0048471; GO:0031117; GO:0034214; GO:0051260; GO:0005819 "ATP binding; ER to Golgi vesicle-mediated transport; alpha-tubulin binding; axonogenesis; beta-tubulin binding; centrosome; cytokinesis, completion of separation; cytoplasmic vesicle; endoplasmic reticulum; endosome; integral to membrane; microtubule; microtubule binding; microtubule bundle formation; microtubule severing; microtubule-severing ATPase activity; midbody; nucleus; perinuclear region of cytoplasm; positive regulation of microtubule depolymerization; protein hexamerization; protein homooligomerization; spindle" IPR003593; IPR003959; IPR003960; IPR007330; IPR027417; IPR017179; Spastin (EC 3.6.4.3) Spast Spg4 Rattus norvegicus (Rat) TR21352_c0_g2_i1 A9GRC9 FTSH1_SORC5 2.00E-17 GO:0005524; GO:0006200; GO:0016887; GO:0016021; GO:0004222; GO:0005886; GO:0030163; GO:0006508; GO:0008270 ATP binding; ATP catabolic process; ATPase activity; integral to membrane; metalloendopeptidase activity; plasma membrane; protein catabolic process; proteolysis; zinc ion binding IPR003593; IPR003959; IPR003960; IPR005936; IPR027417; IPR000642; ATP-dependent zinc metalloprotease FtsH 1 (EC 3.4.24.-) ftsH1 sce0417 Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56)) TR21352_c2_g1_i1 A7T395 SPAST_NEMVE 4.00E-48 GO:0005524; GO:0005737; GO:0016021; GO:0005874; GO:0005815; GO:0051013; GO:0008568; GO:0005634; GO:0031117; GO:0034214 ATP binding; cytoplasm; integral to membrane; microtubule; microtubule organizing center; microtubule severing; microtubule-severing ATPase activity; nucleus; positive regulation of microtubule depolymerization; protein hexamerization IPR003959; IPR003960; IPR027417; IPR017179; Spastin (EC 3.6.4.3) v1g144095 Nematostella vectensis (Starlet sea anemone) TR21358_c0_g2_i1 B0BLT0 ZN593_XENTR 2.00E-38 GO:0046872 metal ion binding IPR007087; IPR015880; IPR022755; Zinc finger protein 593 znf593 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR2136_c0_g1_i1 P50403 SFTPA_CAVPO 1.00E-07 GO:0030246; GO:0005581; GO:0005615; GO:0046872; GO:0007585 carbohydrate binding; collagen; extracellular space; metal ion binding; respiratory gaseous exchange IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Pulmonary surfactant-associated protein A (PSAP) (PSP-A) (SP-A) SFTPA1 SFTP1 SFTPA Cavia porcellus (Guinea pig) TR2136_c0_g2_i1 P86854 PLCL_MYTGA 1.00E-69 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR21366_c0_g1_i1 Q1HRV8 ELVL1_AEDAE 5.00E-21 GO:0006633; GO:0030176; GO:0016740 fatty acid biosynthetic process; integral to endoplasmic reticulum membrane; transferase activity IPR002076; Elongation of very long chain fatty acids protein AAEL008004 (EC 2.3.1.199) (3-keto acyl-CoA synthase AAEL008004) (Very-long-chain 3-oxoacyl-CoA synthase AAEL008004) AAEL008004 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR21369_c0_g1_i1 Q566C8 ANR54_RAT 8.00E-12 GO:0007049; GO:0005737; GO:0030496; GO:0006913; GO:0005634; GO:0045648; GO:0019887; GO:0010627 cell cycle; cytoplasm; midbody; nucleocytoplasmic transport; nucleus; positive regulation of erythrocyte differentiation; protein kinase regulator activity; regulation of intracellular protein kinase cascade IPR002110; IPR020683; Ankyrin repeat domain-containing protein 54 Ankrd54 Rattus norvegicus (Rat) TR21369_c0_g1_i2 Q02357 ANK1_MOUSE 4.00E-27 GO:0030863; GO:0048821; GO:0016020; GO:0015672; GO:0006779; GO:0016529; GO:0007165; GO:0014731 cortical cytoskeleton; erythrocyte development; membrane; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; sarcoplasmic reticulum; signal transduction; spectrin-associated cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) TR21369_c0_g1_i3 Q0VGY8 TANC1_MOUSE 1.00E-18 GO:0043679; GO:0030054; GO:0030425; GO:0097062; GO:0007520; GO:0043025; GO:0014069; GO:0045211; GO:0008542 axon terminus; cell junction; dendrite; dendritic spine maintenance; myoblast fusion; neuronal cell body; postsynaptic density; postsynaptic membrane; visual learning IPR002110; IPR020683; IPR027417; IPR013026; IPR011990; IPR013105; IPR019734; "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" Tanc1 Mus musculus (Mouse) TR21369_c0_g1_i4 Q5DU14 MYO16_MOUSE 5.00E-11 GO:0005524; GO:0051015; GO:0021549; GO:0005829; GO:0003774; GO:0016459; GO:2000134; GO:0008285; GO:0048812; GO:0005730; GO:0005654; GO:0048471; GO:0014065; GO:0005886 P28660 ATP binding; actin filament binding; cerebellum development; cytosol; motor activity; myosin complex; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell proliferation; neuron projection morphogenesis; nucleolus; nucleoplasm; perinuclear region of cytoplasm; phosphatidylinositol 3-kinase cascade; plasma membrane IPR002110; IPR020683; IPR000048; IPR001609; IPR027417; Unconventional myosin-XVI (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16) Myo16 Kiaa0865 Nyap3 Mus musculus (Mouse) TR21371_c0_g1_i1 Q8S920 UBC5A_ORYSJ 6.00E-15 GO:0005524; GO:0004842 ATP binding; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 5A (EC 6.3.2.19) (Ubiquitin carrier protein 5a) (OsUBC5a) (Ubiquitin-protein ligase 5A) UBC5A Os01g0658400 LOC_Os01g46926 OsJ_02884 Oryza sativa subsp. japonica (Rice) TR21371_c0_g1_i2 P70711 U2D2B_RAT 1.00E-19 GO:0005524; GO:0004842 ATP binding; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 D2B (EC 6.3.2.19) (Ubiquitin carrier protein D2B) (Ubiquitin-conjugating enzyme E2(17)KB 2B) (Ubiquitin-conjugating enzyme E2-17 kDa 2B) (Ubiquitin-protein ligase D2B) Ube2d2b Ube2d2 Rattus norvegicus (Rat) TR21373_c0_g2_i1 Q96AH8 RAB7B_HUMAN 7.00E-06 GO:0005525; GO:0005794; GO:0005770; GO:0034499; GO:0005764; GO:0034144; GO:0034164; GO:0045335; GO:0030670; GO:0051092; GO:0032755; GO:0045654; GO:0015031; GO:0007264; GO:0005802 GTP binding; Golgi apparatus; late endosome; late endosome to Golgi transport; lysosome; negative regulation of toll-like receptor 4 signaling pathway; negative regulation of toll-like receptor 9 signaling pathway; phagocytic vesicle; phagocytic vesicle membrane; positive regulation of NF-kappaB transcription factor activity; positive regulation of interleukin-6 production; positive regulation of megakaryocyte differentiation; protein transport; small GTPase mediated signal transduction; trans-Golgi network IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-7b RAB7B Homo sapiens (Human) TR21377_c4_g1_i1 P54310 LIPS_MOUSE 2.00E-16 GO:0005901; GO:0008203; GO:0005829; GO:0046340; GO:0033878; GO:0005811; GO:0042758; GO:0005739; GO:0005634; GO:0042134; GO:0006363; GO:0006361; GO:0019433; GO:0004806 caveola; cholesterol metabolic process; cytosol; diacylglycerol catabolic process; hormone-sensitive lipase activity; lipid particle; long-chain fatty acid catabolic process; mitochondrion; nucleus; rRNA primary transcript binding; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter; triglyceride catabolic process; triglyceride lipase activity IPR013094; IPR010468; IPR002168; Glycerolipid metabolism; triacylglycerol degradation. Hormone-sensitive lipase (HSL) (EC 3.1.1.79) Lipe Mus musculus (Mouse) TR21379_c0_g1_i1 Q9QUN7 TLR2_MOUSE 2.00E-36 GO:0002755; GO:0035354; GO:0035355; GO:0002752; GO:0071221; GO:0071223; GO:0071224; GO:0042892; GO:0050830; GO:0042498; GO:0009897; GO:0052063; GO:0006954; GO:0045087; GO:0016021; GO:0070891; GO:0044130; GO:0032695; GO:0032700; GO:0030670; GO:0032722; GO:0050715; GO:0050729; GO:0032728; GO:0032735; GO:0032741; GO:0032755; GO:0002687; GO:0060907; GO:0045429; GO:0051770; GO:0045944; GO:0042535; GO:0032760; GO:0046982; GO:0002238; GO:0034134; GO:0004888; GO:0042497 MyD88-dependent toll-like receptor signaling pathway; Toll-like receptor 1-Toll-like receptor 2 protein complex; Toll-like receptor 2-Toll-like receptor 6 protein complex; cell surface pattern recognition receptor signaling pathway; cellular response to bacterial lipopeptide; cellular response to lipoteichoic acid; cellular response to peptidoglycan; chloramphenicol transport; defense response to Gram-positive bacterium; diacyl lipopeptide binding; external side of plasma membrane; induction by symbiont of defense-related host nitric oxide production; inflammatory response; innate immune response; integral to membrane; lipoteichoic acid binding; negative regulation of growth of symbiont in host; negative regulation of interleukin-12 production; negative regulation of interleukin-17 production; phagocytic vesicle membrane; positive regulation of chemokine production; positive regulation of cytokine secretion; positive regulation of inflammatory response; positive regulation of interferon-beta production; positive regulation of interleukin-12 production; positive regulation of interleukin-18 production; positive regulation of interleukin-6 production; positive regulation of leukocyte migration; positive regulation of macrophage cytokine production; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of tumor necrosis factor production; protein heterodimerization activity; response to molecule of fungal origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity; triacyl lipopeptide binding IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) Tlr2 Mus musculus (Mouse) TR21379_c1_g1_i1 Q6WRI0 IGS10_HUMAN 7.00E-06 GO:0030154; GO:0005576; GO:0007275; GO:0001503 cell differentiation; extracellular region; multicellular organismal development; ossification IPR000483; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR003591; IPR000372; Immunoglobulin superfamily member 10 (IgSF10) (Calvaria mechanical force protein 608) (CMF608) IGSF10 CMF608 Homo sapiens (Human) TR2138_c0_g1_i1 P29174 CSDE1_CAVPO 5.00E-30 GO:0070937; GO:0003677; GO:0003723; GO:0005743; GO:0070966; GO:0006355 "CRD-mediated mRNA stability complex; DNA binding; RNA binding; mitochondrial inner membrane; nuclear-transcribed mRNA catabolic process, no-go decay; regulation of transcription, DNA-dependent" IPR011129; IPR002059; IPR012340; IPR024642; Cold shock domain-containing protein E1 (Protein UNR) (Fragment) CSDE1 UNR Cavia porcellus (Guinea pig) TR21384_c0_g1_i2 Q5XF90 AT134_MOUSE 1.00E-10 GO:0005524; GO:0006200; GO:0019829; GO:0016021; GO:0046872 ATP binding; ATP catabolic process; cation-transporting ATPase activity; integral to membrane; metal ion binding IPR004014; IPR006544; IPR023299; IPR018303; IPR008250; IPR001757; IPR023214; Probable cation-transporting ATPase 13A4 (EC 3.6.3.-) (P5-ATPase isoform 4) Atp13a4 Mus musculus (Mouse) TR21387_c1_g1_i1 Q9VBW3 CAD96_DROME 1.00E-22 GO:0005524; GO:0007030; GO:0005509; GO:0016339; GO:0007156; GO:0005887; GO:0045792; GO:0004713; GO:0004714 ATP binding; Golgi organization; calcium ion binding; calcium-dependent cell-cell adhesion; homophilic cell adhesion; integral to plasma membrane; negative regulation of cell size; protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity IPR002126; IPR015919; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14) Cad96Ca HD-14 CG10244 Drosophila melanogaster (Fruit fly) TR21387_c1_g2_i1 Q5GIT4 VGFR2_DANRE 7.00E-20 GO:0005524; GO:0001525; GO:0030154; GO:0030054; GO:0016023; GO:0005769; GO:0005887; GO:0005634; GO:0018108; GO:0048010; GO:0038084; GO:0005021 ATP binding; angiogenesis; cell differentiation; cell junction; cytoplasmic membrane-bounded vesicle; early endosome; integral to plasma membrane; nucleus; peptidyl-tyrosine phosphorylation; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor signaling pathway; vascular endothelial growth factor-activated receptor activity IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR001824; IPR009136; IPR009137; Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1b) (FLK-1b) (Kinase insert domain receptor) (Kinase insert domain receptor-B) (Protein-tyrosine kinase receptor flk-1b) (Vascular endothelial growth factor receptor 2 homolog B) (VEGFR-2 homolog B) kdr flk1b kdrb si:busm1-205d10.1 si:ch211-254j6.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR21387_c1_g3_i1 Q62190 RON_MOUSE 1.00E-20 GO:0005524; GO:0045087; GO:0016021; GO:0019048; GO:0007275; GO:0018108; GO:0005886; GO:0043406; GO:0051897; GO:0009615; GO:0001725; GO:0004714; GO:0007169 ATP binding; innate immune response; integral to membrane; modulation by virus of host morphology or physiology; multicellular organismal development; peptidyl-tyrosine phosphorylation; plasma membrane; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling cascade; response to virus; stress fiber; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR013783; IPR014756; IPR002909; IPR011009; IPR016201; IPR000719; IPR017441; IPR001627; IPR001245; IPR008266; IPR020635; IPR016244; IPR015943; Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (Stem cell-derived tyrosine kinase) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain] Mst1r Ron Stk Mus musculus (Mouse) TR21392_c0_g1_i1 Q8IPH9 SLOB_DROME 2.00E-34 GO:0005737; GO:0007274; GO:0004672; GO:0042391; GO:0050804; GO:0042594 P29310; Q03720 cytoplasm; neuromuscular synaptic transmission; protein kinase activity; regulation of membrane potential; regulation of synaptic transmission; response to starvation IPR011009; Slowpoke-binding protein Slob CG43756 Drosophila melanogaster (Fruit fly) TR21393_c2_g1_i1 P28024 PSB4_XENLA 7.00E-21 GO:0005737; GO:0005634; GO:0005839; GO:0051603; GO:0004298 cytoplasm; nucleus; proteasome core complex; proteolysis involved in cellular protein catabolic process; threonine-type endopeptidase activity IPR016050; IPR016295; IPR001353; IPR023333; Proteasome subunit beta type-4 (EC 3.4.25.1) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (Fragment) psmb4 Xenopus laevis (African clawed frog) TR21399_c3_g1_i1 Q13263 TIF1B_HUMAN 3.00E-08 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR21401_c1_g1_i1 Q86W56 PARG_HUMAN 3.00E-17 GO:0005975; GO:0005737; GO:0005829; GO:0016045; GO:0005759; GO:0005634; GO:0004649; GO:0006974 carbohydrate metabolic process; cytoplasm; cytosol; detection of bacterium; mitochondrial matrix; nucleus; poly(ADP-ribose) glycohydrolase activity; response to DNA damage stimulus IPR007724; Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) PARG Homo sapiens (Human) TR21411_c0_g1_i1 Q9DA42 CT085_MOUSE 1.00E-05 IPR020339; Uncharacterized protein C20orf85 homolog Mus musculus (Mouse) TR21414_c0_g2_i1 O08585 CLCA_MOUSE 7.00E-33 GO:0030132; GO:0030130; GO:0016023; GO:0006886; GO:0005198; GO:0016192 clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; cytoplasmic membrane-bounded vesicle; intracellular protein transport; structural molecule activity; vesicle-mediated transport IPR000996; Clathrin light chain A (Lca) Clta Mus musculus (Mouse) TR21419_c1_g1_i1 O75096 LRP4_HUMAN 2.00E-08 GO:0016055; GO:0005509; GO:0030154; GO:0009953; GO:0042733; GO:0006897; GO:0030198; GO:0001942; GO:0016021; GO:0001822; GO:0090090; GO:0030279; GO:0042475; GO:0005886; GO:0009954; GO:0043113; GO:0001932; GO:0051124 Wnt receptor signaling pathway; calcium ion binding; cell differentiation; dorsal/ventral pattern formation; embryonic digit morphogenesis; endocytosis; extracellular matrix organization; hair follicle development; integral to membrane; kidney development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of ossification; odontogenesis of dentin-containing tooth; plasma membrane; proximal/distal pattern formation; receptor clustering; regulation of protein phosphorylation; synaptic growth at neuromuscular junction IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) TR2142_c0_g1_i1 A4QNR8 LENG8_DANRE 2.00E-22 IPR005062; Leukocyte receptor cluster member 8 homolog leng8 zgc:158262 Danio rerio (Zebrafish) (Brachydanio rerio) TR2142_c0_g2_i1 Q8CBY3 LENG8_MOUSE 4.00E-25 IPR005062; Leukocyte receptor cluster member 8 homolog Leng8 Mus musculus (Mouse) TR21420_c0_g1_i1 P86854 PLCL_MYTGA 2.00E-22 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR21420_c0_g2_i1 Q5IS41 NCAN_PANTR 2.00E-17 GO:0005509; GO:0030246; GO:0007155; GO:0005576; GO:0005540 calcium ion binding; carbohydrate binding; cell adhesion; extracellular region; hyaluronic acid binding IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Neurocan core protein (Chondroitin sulfate proteoglycan 3) NCAN CSPG3 Pan troglodytes (Chimpanzee) TR21423_c0_g1_i1 Q8UVC1 INVS_DANRE 4.00E-23 GO:0016055; GO:0005737; GO:0005856; GO:0007275 Wnt receptor signaling pathway; cytoplasm; cytoskeleton; multicellular organismal development IPR002110; IPR020683; IPR000048; Inversin invs Danio rerio (Zebrafish) (Brachydanio rerio) TR21423_c0_g1_i2 Q12955 ANK3_HUMAN 4.00E-78 GO:0043001; GO:0030315; GO:0007411; GO:0043194; GO:0007409; GO:0016323; GO:0045296; GO:0009986; GO:0043034; GO:0014704; GO:0044325; GO:0016328; GO:0005764; GO:0072660; GO:0071709; GO:0000281; GO:0033268; GO:0033270; GO:0010628; GO:1900827; GO:0045838; GO:2000651; GO:0010765; GO:0045211; GO:0030674; GO:0072661; GO:0019228; GO:0043266; GO:0007165; GO:0030507; GO:0014731; GO:0005200; GO:0050808 "Golgi to plasma membrane protein transport; T-tubule; axon guidance; axon initial segment; axonogenesis; basolateral plasma membrane; cadherin binding; cell surface; costamere; intercalated disc; ion channel binding; lateral plasma membrane; lysosome; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; node of Ranvier; paranode region of axon; positive regulation of gene expression; positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; postsynaptic membrane; protein binding, bridging; protein targeting to plasma membrane; regulation of action potential in neuron; regulation of potassium ion transport; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton; synapse organization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) TR21423_c0_g2_i1 Q54GC8 ACBD6_DICDI 3.00E-10 GO:0005737; GO:0000062; GO:0008289 cytoplasm; fatty-acyl-CoA binding; lipid binding IPR000582; IPR002110; IPR020683; IPR014352; Acyl-CoA-binding domain-containing protein 6 homolog acbd6 DDB_G0290237 Dictyostelium discoideum (Slime mold) TR21428_c1_g1_i1 Q9P275 UBP36_HUMAN 2.00E-14 GO:0008234; GO:0005730; GO:0004221; GO:0006511 cysteine-type peptidase activity; nucleolus; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) USP36 KIAA1453 Homo sapiens (Human) TR21428_c2_g1_i1 Q24574 UBPE_DROME 4.00E-12 GO:0042675; GO:0008234; GO:0005737; GO:0005634; GO:0016579; GO:0050821; GO:0031935; GO:0004221; GO:0006511 compound eye cone cell differentiation; cysteine-type peptidase activity; cytoplasm; nucleus; protein deubiquitination; protein stabilization; regulation of chromatin silencing; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 64E (EC 3.4.19.12) (Ubiquitin thioesterase 64E) (Ubiquitin-specific-processing protease 64E) (Deubiquitinating enzyme 64E) Ubp64E D-UBP-64E CG5486 Drosophila melanogaster (Fruit fly) TR21428_c3_g1_i1 B1AQJ2 UBP36_MOUSE 6.00E-61 GO:0008234; GO:0005730; GO:0004221; GO:0006511 cysteine-type peptidase activity; nucleolus; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) Usp36 Kiaa1453 Mus musculus (Mouse) TR21432_c0_g1_i1 P86854 PLCL_MYTGA 9.00E-14 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR21435_c0_g1_i1 P00125 CY1_BOVIN 5.00E-120 GO:0030054; GO:0009055; GO:0020037; GO:0016021; GO:0005506; GO:0005743; GO:0055114; GO:0070469 cell junction; electron carrier activity; heme binding; integral to membrane; iron ion binding; mitochondrial inner membrane; oxidation-reduction process; respiratory chain IPR009056; IPR002326; IPR021157; "Cytochrome c1, heme protein, mitochondrial (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1)" CYC1 Bos taurus (Bovine) TR21437_c0_g2_i2 Q96RJ6 FER3L_HUMAN 2.00E-25 GO:0003677; GO:0045892; GO:0005634; GO:0006351 "DNA binding; negative regulation of transcription, DNA-dependent; nucleus; transcription, DNA-dependent" IPR011598; Fer3-like protein (Basic helix-loop-helix protein N-twist) (Class A basic helix-loop-helix protein 31) (bHLHa31) (Nephew of atonal 3) (Neuronal twist) FERD3L BHLHA31 NATO3 NTWIST Homo sapiens (Human) TR2144_c0_g1_i1 Q7ZWJ3 OSTC_DANRE 7.00E-77 GO:0016021 integral to membrane IPR021149; Oligosaccharyltransferase complex subunit ostc ostc zgc:56559 Danio rerio (Zebrafish) (Brachydanio rerio) TR21445_c4_g1_i1 Q5UPX1 YL289_MIMIV 2.00E-06 IPR002110; IPR020683; Putative ankyrin repeat protein L289 MIMI_L289 Acanthamoeba polyphaga mimivirus (APMV) TR21447_c2_g1_i1 O28550 Y1724_ARCFU 3.00E-11 GO:0016787 hydrolase activity IPR005502; Uncharacterized protein AF_1724 (EC 3.2.2.-) AF_1724 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) TR21448_c4_g1_i1 Q5VU97 CAHD1_HUMAN 3.00E-15 GO:0006816; GO:0016021 calcium ion transport; integral to membrane IPR004010; IPR013608; IPR002035; VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) CACHD1 KIAA1573 VWCD1 Homo sapiens (Human) TR21453_c1_g1_i1 Q14591 ZN271_HUMAN 6.00E-58 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 271 (CT-ZFP48) (Epstein-Barr virus-induced zinc finger protein) (EBV-induced zinc finger protein) (ZNF-EB) (Zinc finger protein HZF7) (Zinc finger protein ZNFphex133) (Zinc finger protein dp) (ZNF-dp) ZNF271 ZNFEB Homo sapiens (Human) TR21456_c0_g1_i1 A8WGS4 TLCD2_DANRE 8.00E-28 GO:0016021 integral to membrane IPR006634; TLC domain-containing protein 2 tlcd2 zgc:175098 Danio rerio (Zebrafish) (Brachydanio rerio) TR21467_c4_g1_i1 D3ZJP6 MYO10_RAT 2.00E-06 GO:0005524; GO:0051015; GO:0030898; GO:0005938; GO:0030705; GO:0005829; GO:0031527; GO:0032433; GO:0030027; GO:0016459; GO:0005547; GO:0060002; GO:0008360; GO:0051489; GO:0001726 "ATP binding; actin filament binding; actin-dependent ATPase activity; cell cortex; cytoskeleton-dependent intracellular transport; cytosol; filopodium membrane; filopodium tip; lamellipodium; myosin complex; phosphatidylinositol-3,4,5-trisphosphate binding; plus-end directed microfilament motor activity; regulation of cell shape; regulation of filopodium assembly; ruffle" IPR019749; IPR014352; IPR019748; IPR000299; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; IPR001849; Unconventional myosin-X (Unconventional myosin-10) Myo10 Rattus norvegicus (Rat) TR21469_c0_g1_i1 P07291 MLE_AEQIR 7.00E-65 GO:0005509; GO:0016459 calcium ion binding; myosin complex IPR011992; IPR002048; "Myosin essential light chain, striated adductor muscle (E-LC) (Sulfhydryl light chain) (SHLC)" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR21479_c1_g1_i1 Q8R151 ZNFX1_MOUSE 8.00E-14 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR21482_c0_g1_i1 Q6AZB8 HARB1_DANRE 7.00E-19 GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) TR21485_c1_g1_i1 Q9IB89 ZIC5_XENLA 3.00E-89 GO:0003677; GO:0046872; GO:0007399; GO:0014029; GO:0005634 DNA binding; metal ion binding; nervous system development; neural crest formation; nucleus IPR007087; IPR015880; IPR013087; Zinc finger protein ZIC 5 (XZic5) (XlZic5) (Zinc finger protein of the cerebellum 5) zic5 Xenopus laevis (African clawed frog) TR21488_c1_g1_i1 P09470 ACE_MOUSE 7.00E-28 GO:0004180; GO:0005576; GO:0060047; GO:0042447; GO:0016021; GO:0001822; GO:0046872; GO:0008237; GO:0002446; GO:0008241; GO:0005886; GO:0003084; GO:0006508; GO:0007283 carboxypeptidase activity; extracellular region; heart contraction; hormone catabolic process; integral to membrane; kidney development; metal ion binding; metallopeptidase activity; neutrophil mediated immunity; peptidyl-dipeptidase activity; plasma membrane; positive regulation of systemic arterial blood pressure; proteolysis; spermatogenesis IPR001548; "Angiotensin-converting enzyme (ACE) (EC 3.2.1.-) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form]" Ace Dcp1 Mus musculus (Mouse) TR21489_c4_g1_i1 O14975 S27A2_HUMAN 2.00E-11 GO:0005524; GO:0006699; GO:0005788; GO:0001561; GO:0006635; GO:0015245; GO:0030176; GO:0005779; GO:0044539; GO:0004467; GO:0097089; GO:0005739; GO:0050197; GO:0070251; GO:0042760; GO:0031957 ATP binding; bile acid biosynthetic process; endoplasmic reticulum lumen; fatty acid alpha-oxidation; fatty acid beta-oxidation; fatty acid transporter activity; integral to endoplasmic reticulum membrane; integral to peroxisomal membrane; long-chain fatty acid import; long-chain fatty acid-CoA ligase activity; methyl-branched fatty acid metabolic process; mitochondrion; phytanate-CoA ligase activity; pristanate-CoA ligase activity; very long-chain fatty acid catabolic process; very long-chain fatty acid-CoA ligase activity IPR025110; IPR020845; IPR000873; "Very long-chain acyl-CoA synthetase (VLACS) (VLCS) (EC 6.2.1.-) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 2) (THCA-CoA ligase) (Very long-chain-fatty-acid-CoA ligase)" SLC27A2 ACSVL1 FACVL1 FATP2 VLACS Homo sapiens (Human) TR21491_c0_g1_i1 Q5REG4 DTX3_PONAB 2.00E-14 GO:0007219; GO:0005737; GO:0016874; GO:0016567; GO:0008270 Notch signaling pathway; cytoplasm; ligase activity; protein ubiquitination; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase DTX3 (EC 6.3.2.-) (Protein deltex-3) (Deltex3) DTX3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR21498_c1_g1_i1 Q9HB20 PKHA3_HUMAN 7.00E-21 GO:0005545; GO:0005794; GO:0016020; GO:0005543 1-phosphatidylinositol binding; Golgi apparatus; membrane; phospholipid binding IPR011993; IPR001849; Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1) PLEKHA3 FAPP1 Homo sapiens (Human) TR21502_c0_g1_i1 Q0IHW8 CLU_XENTR 3.00E-43 GO:0005737; GO:0048312 cytoplasm; intracellular distribution of mitochondria IPR027523; IPR025697; IPR028275; IPR023231; IPR011990; Clustered mitochondria protein homolog cluh Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR2151_c0_g1_i1 P81004 VDAC2_XENLA 4.00E-141 GO:0005741; GO:0000166; GO:0046930; GO:0015288; GO:0008308 mitochondrial outer membrane; nucleotide binding; pore complex; porin activity; voltage-gated anion channel activity IPR023614; IPR001925; IPR027246; Voltage-dependent anion-selective channel protein 2 (VDAC-2) (Outer mitochondrial membrane protein porin) vdac2 Xenopus laevis (African clawed frog) TR21511_c1_g1_i2 P79403 GANAB_PIG 6.00E-29 GO:0005794; GO:0030246; GO:0005975; GO:0005783; GO:0033919; GO:0042470 "Golgi apparatus; carbohydrate binding; carbohydrate metabolic process; endoplasmic reticulum; glucan 1,3-alpha-glucosidase activity; melanosome" IPR011013; IPR000322; IPR025887; IPR017853; Glycan metabolism; N-glycan metabolism. Neutral alpha-glucosidase AB (EC 3.2.1.84) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) GANAB Sus scrofa (Pig) TR21514_c3_g1_i1 P0CK97 S35E2_HUMAN 1.00E-07 GO:0016021 integral to membrane IPR000620; Solute carrier family 35 member E2 SLC35E2 Homo sapiens (Human) TR21516_c1_g1_i1 Q8T2Q0 ZDHC6_DICDI 2.00E-11 GO:0016021; GO:0016746; GO:0008270 "integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR002110; IPR020683; IPR001594; Putative ZDHHC-type palmitoyltransferase 6 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 6) DDB_G0275149 Dictyostelium discoideum (Slime mold) TR21516_c3_g1_i1 Q9P0K7 RAI14_HUMAN 4.00E-08 GO:0005938; GO:0005856; GO:0005739; GO:0005634 cell cortex; cytoskeleton; mitochondrion; nucleus IPR002110; IPR020683; Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) RAI14 KIAA1334 NORPEG Homo sapiens (Human) TR21518_c1_g1_i1 Q8N2Z9 CENPS_HUMAN 5.00E-25 GO:0003677; GO:0006281; GO:0071821; GO:0043240; GO:0051301; GO:0003682; GO:0000777; GO:0005829; GO:0007067; GO:0000278; GO:0031398; GO:0031297; GO:0000712 A8MT69 DNA binding; DNA repair; FANCM-MHF complex; Fanconi anaemia nuclear complex; cell division; chromatin binding; condensed chromosome kinetochore; cytosol; mitosis; mitotic cell cycle; positive regulation of protein ubiquitination; replication fork processing; resolution of meiotic recombination intermediates IPR009072; Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain-containing protein 1) (FANCM-interacting histone fold protein 1) (Fanconi anemia-associated polypeptide of 16 kDa) APITD1 CENPS FAAP16 MHF1 Homo sapiens (Human) TR21520_c0_g2_i1 Q8BZ39 NMUR2_MOUSE 3.00E-18 GO:0005525; GO:0043006; GO:0050482; GO:0006816; GO:0007417; GO:0007204; GO:0007625; GO:0048016; GO:0016021; GO:0005229; GO:0042924; GO:0001607; GO:0008188; GO:0007200; GO:0005886; GO:0002023; GO:0048265 GTP binding; activation of phospholipase A2 activity by calcium-mediated signaling; arachidonic acid secretion; calcium ion transport; central nervous system development; elevation of cytosolic calcium ion concentration; grooming behavior; inositol phosphate-mediated signaling; integral to membrane; intracellular calcium activated chloride channel activity; neuromedin U binding; neuromedin U receptor activity; neuropeptide receptor activity; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; reduction of food intake in response to dietary excess; response to pain IPR000276; IPR017452; IPR005390; IPR005392; Neuromedin-U receptor 2 (NMU-R2) Nmur2 Mus musculus (Mouse) TR21520_c1_g1_i1 Q9JJI5 NMUR1_RAT 4.00E-26 GO:0016021; GO:0001607; GO:0005886 integral to membrane; neuromedin U receptor activity; plasma membrane IPR000276; IPR017452; IPR005390; IPR005391; Neuromedin-U receptor 1 (NMU-R1) (G-protein coupled receptor 66) (G-protein coupled receptor FM-3) Nmur1 Gpr66 Rattus norvegicus (Rat) TR21527_c0_g1_i1 P83425 HIP_MYTED 5.00E-38 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR21528_c0_g2_i1 P63170 DYL1_RAT 8.00E-13 GO:0008180; GO:0006915; GO:0005813; GO:0005868; GO:0005829; GO:0004857; GO:0000776; GO:0016020; GO:0005874; GO:0007017; GO:0005739; GO:0072686; GO:0003774; GO:0042326; GO:0042133; GO:0006809; GO:0030235; GO:0042803; GO:0006355; GO:0006351; GO:0006810 "COP9 signalosome; apoptotic process; centrosome; cytoplasmic dynein complex; cytosol; enzyme inhibitor activity; kinetochore; membrane; microtubule; microtubule-based process; mitochondrion; mitotic spindle; motor activity; negative regulation of phosphorylation; neurotransmitter metabolic process; nitric oxide biosynthetic process; nitric-oxide synthase regulator activity; protein homodimerization activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent; transport" IPR019763; IPR001372; "Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN)" Dynll1 Dncl1 Dnclc1 Pin Rattus norvegicus (Rat) TR21529_c2_g1_i1 Q96DM1 PGBD4_HUMAN 2.00E-59 PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) TR21532_c0_g1_i1 Q29RV0 CDN2D_BOVIN 2.00E-08 GO:0000731; GO:0000082; GO:0048102; GO:0007050; GO:0004861; GO:0005737; GO:0030308; GO:0008285; GO:0043154; GO:1902230; GO:0005634; GO:0000079; GO:0009411; GO:0032526; GO:0033280; GO:0007605 DNA synthesis involved in DNA repair; G1/S transition of mitotic cell cycle; autophagic cell death; cell cycle arrest; cyclin-dependent protein serine/threonine kinase inhibitor activity; cytoplasm; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; nucleus; regulation of cyclin-dependent protein serine/threonine kinase activity; response to UV; response to retinoic acid; response to vitamin D; sensory perception of sound IPR002110; IPR020683; Cyclin-dependent kinase 4 inhibitor D (p19-INK4d) CDKN2D Bos taurus (Bovine) TR21534_c0_g1_i2 Q5EBL2 ZN628_HUMAN 1.00E-15 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 628 ZNF628 Homo sapiens (Human) TR21538_c0_g1_i1 Q96KE9 BTBD6_HUMAN 1.00E-06 GO:0000932 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6 (Lens BTB domain protein) BTBD6 BDPL Homo sapiens (Human) TR21542_c1_g1_i1 Q94360 NDUS7_CAEEL 6.00E-69 GO:0051539; GO:0008137; GO:0046872; GO:0005739; GO:0048038; GO:0070469 "4 iron, 4 sulfur cluster binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; mitochondrion; quinone binding; respiratory chain" IPR006137; IPR006138; "Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit)" nduf-7 W10D5.2 Caenorhabditis elegans TR21544_c0_g1_i1 Q3T0Y3 ST1B1_BOVIN 7.00E-46 GO:0004062; GO:0005737; GO:0009812; GO:0008202; GO:0051923; GO:0042403; GO:0006805 aryl sulfotransferase activity; cytoplasm; flavonoid metabolic process; steroid metabolic process; sulfation; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) SULT1B1 Bos taurus (Bovine) TR21546_c0_g1_i2 Q6NUC1 CNFNA_XENLA 4.00E-09 IPR006461; Cornifelin homolog A cnfn-a Xenopus laevis (African clawed frog) TR21556_c1_g1_i1 Q08347 BDS1_YEAST 2.00E-46 GO:0018741; GO:0004065; GO:0018909; GO:0032934 alkyl sulfatase activity; arylsulfatase activity; dodecyl sulfate metabolic process; sterol binding IPR001279; IPR003033; Alkyl/aryl-sulfatase BDS1 (EC 3.1.6.-) (Bacterially-derived sulfatase 1) BDS1 YOL164W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR21556_c1_g1_i2 Q08347 BDS1_YEAST 3.00E-26 GO:0018741; GO:0004065; GO:0018909; GO:0032934 alkyl sulfatase activity; arylsulfatase activity; dodecyl sulfate metabolic process; sterol binding IPR001279; IPR003033; Alkyl/aryl-sulfatase BDS1 (EC 3.1.6.-) (Bacterially-derived sulfatase 1) BDS1 YOL164W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR21557_c0_g2_i1 Q9JI75 NQO2_MOUSE 5.00E-78 GO:0005737; GO:0001512; GO:0007613; GO:0046872 cytoplasm; dihydronicotinamide riboside quinone reductase activity; memory; metal ion binding IPR003680; Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.99.2) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2) Nqo2 Nmor2 Mus musculus (Mouse) TR21557_c0_g2_i2 P43340 YCAK_ECOLI 1.00E-07 GO:0010181; GO:0016491 FMN binding; oxidoreductase activity IPR003680; Uncharacterized NAD(P)H oxidoreductase YcaK (EC 1.6.99.-) ycaK b0901 JW0884 Escherichia coli (strain K12) TR21559_c0_g1_i1 Q921M4 GOGA2_MOUSE 1.00E-10 GO:0005794; GO:0032580; GO:0051645; GO:0005801; GO:0050772 Golgi apparatus; Golgi cisterna membrane; Golgi localization; cis-Golgi network; positive regulation of axonogenesis IPR024858; Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) Golga2 Mus musculus (Mouse) TR21562_c0_g1_i1 Q80V03 ADCK5_MOUSE 7.00E-38 GO:0016021; GO:0005739; GO:0004674 integral to membrane; mitochondrion; protein serine/threonine kinase activity IPR011009; IPR004147; Uncharacterized aarF domain-containing protein kinase 5 (EC 2.7.11.-) Adck5 Mus musculus (Mouse) TR21563_c0_g1_i1 Q3T0J3 RM16_BOVIN 3.00E-31 GO:0005739; GO:0019843; GO:0005840; GO:0003735; GO:0006412 mitochondrion; rRNA binding; ribosome; structural constituent of ribosome; translation IPR016180; IPR000114; "39S ribosomal protein L16, mitochondrial (L16mt) (MRP-L16)" MRPL16 Bos taurus (Bovine) TR21565_c0_g1_i1 Q27746 DNMT1_PARLI 2.00E-21 GO:0003886; GO:0003677; GO:0005634; GO:0008270 DNA (cytosine-5-)-methyltransferase activity; DNA binding; nucleus; zinc ion binding IPR001025; IPR018117; IPR001525; IPR022702; IPR010506; IPR017198; IPR002857; DNA (cytosine-5)-methyltransferase PliMCI (EC 2.1.1.37) (DNA methyltransferase PliMCI) (DNA MTase PliMCI) (M.PliMCI) (Dnmt1) (MCMT) DNMT PLIMCIM Paracentrotus lividus (Common sea urchin) TR21565_c1_g1_i1 Q9Z330 DNMT1_RAT 3.00E-24 GO:0051718; GO:0010424; GO:0046498; GO:0046499; GO:0046500; GO:0016568; GO:0003690; GO:0010216; GO:0008327; GO:0005634; GO:0043234; GO:0006355; GO:0006351; GO:0045322; GO:0008270 "DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates; DNA methylation on cytosine within a CG sequence; S-adenosylhomocysteine metabolic process; S-adenosylmethioninamine metabolic process; S-adenosylmethionine metabolic process; chromatin modification; double-stranded DNA binding; maintenance of DNA methylation; methyl-CpG binding; nucleus; protein complex; regulation of transcription, DNA-dependent; transcription, DNA-dependent; unmethylated CpG binding; zinc ion binding" IPR001025; IPR018117; IPR001525; IPR022702; IPR010506; IPR017198; IPR002857; DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (DNA MTase RnoIP) (M.RnoIP) (DNA methyltransferase I) (MCMT) Dnmt1 Rattus norvegicus (Rat) TR21565_c2_g1_i1 P26358 DNMT1_HUMAN 5.00E-25 GO:0003886; GO:0003677; GO:0003723; GO:0071230; GO:0005721; GO:0016568; GO:0016458; GO:0010216; GO:0008327; GO:0051573; GO:0000122; GO:0005634; GO:0010628; GO:0051571; GO:0042127; GO:0005657; GO:0006351; GO:0008270 O75530; Q15910; P48552; Q96EB6; Q96T88 "DNA (cytosine-5-)-methyltransferase activity; DNA binding; RNA binding; cellular response to amino acid stimulus; centromeric heterochromatin; chromatin modification; gene silencing; maintenance of DNA methylation; methyl-CpG binding; negative regulation of histone H3-K9 methylation; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of gene expression; positive regulation of histone H3-K4 methylation; regulation of cell proliferation; replication fork; transcription, DNA-dependent; zinc ion binding" IPR001025; IPR018117; IPR001525; IPR022702; IPR010506; IPR017198; IPR002857; DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) DNMT1 AIM CXXC9 DNMT Homo sapiens (Human) TR21566_c1_g1_i1 Q8C790 F221A_MOUSE 9.00E-54 IPR026755; Protein FAM221A Fam221a Mus musculus (Mouse) TR21569_c0_g2_i1 P86854 PLCL_MYTGA 2.00E-22 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR21569_c1_g1_i2 Q9WUB9 MARCO_MESAU 2.00E-08 GO:0005581; GO:0045087; GO:0016021; GO:0005044 collagen; innate immune response; integral to membrane; scavenger receptor activity IPR008160; IPR001190; IPR017448; Macrophage receptor MARCO (Macrophage receptor with collagenous structure) MARCO Mesocricetus auratus (Golden hamster) TR21574_c0_g1_i1 Q08D64 ABCB6_XENTR 4.00E-19 GO:0005524; GO:0006200; GO:0042626; GO:0005794; GO:0005783; GO:0016021; GO:0005741; GO:0005886 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; Golgi apparatus; endoplasmic reticulum; integral to membrane; mitochondrial outer membrane; plasma membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; "ATP-binding cassette sub-family B member 6, mitochondrial" abcb6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR21574_c0_g2_i1 O70595 ABCB6_RAT 2.00E-08 GO:0005524; GO:0042626; GO:0005794; GO:0007420; GO:0070574; GO:0071585; GO:0015562; GO:0005783; GO:0020037; GO:0015439; GO:0016021; GO:0031307; GO:0005739; GO:0005886; GO:0006779; GO:0043588; GO:0005774 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; Golgi apparatus; brain development; cadmium ion transmembrane transport; detoxification of cadmium ion; efflux transmembrane transporter activity; endoplasmic reticulum; heme binding; heme-transporting ATPase activity; integral to membrane; integral to mitochondrial outer membrane; mitochondrion; plasma membrane; porphyrin-containing compound biosynthetic process; skin development; vacuolar membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; "ATP-binding cassette sub-family B member 6, mitochondrial (Ubiquitously-expressed mammalian ABC half transporter)" Abcb6 Umat Rattus norvegicus (Rat) TR21576_c0_g1_i1 Q8N0N3 BGBP_PENMO 6.00E-38 GO:0001872; GO:0005975; GO:0005576; GO:0004553; GO:0045087 "(1->3)-beta-D-glucan binding; carbohydrate metabolic process; extracellular region; hydrolase activity, hydrolyzing O-glycosyl compounds; innate immune response" IPR008985; IPR013320; IPR000757; "Beta-1,3-glucan-binding protein (GBP)" Penaeus monodon (Giant tiger prawn) TR21576_c2_g1_i1 Q9NHB0 BGBP1_DROME 3.00E-20 GO:0001872; GO:0046658; GO:0005975; GO:0050830; GO:0005576; GO:0004553; GO:0045087; GO:0001530; GO:0042834; GO:0009253; GO:0008329 "(1->3)-beta-D-glucan binding; anchored to plasma membrane; carbohydrate metabolic process; defense response to Gram-positive bacterium; extracellular region; hydrolase activity, hydrolyzing O-glycosyl compounds; innate immune response; lipopolysaccharide binding; peptidoglycan binding; peptidoglycan catabolic process; signaling pattern recognition receptor activity" IPR008985; IPR013320; IPR000757; Gram-negative bacteria-binding protein 1 GNBP1 CG6895 Drosophila melanogaster (Fruit fly) TR21579_c1_g1_i1 Q96FC7 PHIPL_HUMAN 3.00E-34 GO:0005737; GO:0005739 cytoplasm; mitochondrion IPR003961; IPR013783; Phytanoyl-CoA hydroxylase-interacting protein-like PHYHIPL KIAA1796 UNQ6309/PRO20934 Homo sapiens (Human) TR21579_c1_g1_i2 Q6AX58 PHIPL_XENLA 2.00E-33 IPR003961; IPR013783; Phytanoyl-CoA hydroxylase-interacting protein-like phyhipl Xenopus laevis (African clawed frog) TR21580_c1_g1_i1 Q0IHB3 PTR1A_XENLA 5.00E-32 GO:0018342; GO:0008318 protein prenylation; protein prenyltransferase activity IPR002088; Protein prenyltransferase alpha subunit repeat-containing protein 1-A ptar1-a Xenopus laevis (African clawed frog) TR21581_c0_g1_i1 P82174 LYS_GALME 5.00E-21 GO:0016998; GO:0019835; GO:0042742; GO:0003796 cell wall macromolecule catabolic process; cytolysis; defense response to bacterium; lysozyme activity IPR001916; IPR019799; IPR000974; IPR023346; "Lysozyme (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase)" Galleria mellonella (Greater wax moth) TR21585_c0_g1_i1 B3DK56 PTPRU_DANRE 4.00E-12 GO:0007155; GO:0030154; GO:0030054; GO:0016021; GO:0035335; GO:0005886; GO:0004725; GO:0001757 cell adhesion; cell differentiation; cell junction; integral to membrane; peptidyl-tyrosine dephosphorylation; plasma membrane; protein tyrosine phosphatase activity; somite specification IPR008985; IPR003961; IPR013783; IPR003599; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi) ptpru rptppsi Danio rerio (Zebrafish) (Brachydanio rerio) TR21587_c0_g1_i1 Q8NG50 RDM1_HUMAN 3.00E-11 GO:0015030; GO:0003677; GO:0006310; GO:0006281; GO:0016605; GO:0003723; GO:0005737; GO:0005730; GO:0000166 Cajal body; DNA binding; DNA recombination; DNA repair; PML body; RNA binding; cytoplasm; nucleolus; nucleotide binding IPR012677; IPR007232; IPR000504; RAD52 motif-containing protein 1 (RAD52 homolog B) RDM1 RAD52B Homo sapiens (Human) TR21587_c0_g2_i1 Q8JFQ4 RDM1_CHICK 4.00E-11 GO:0003677; GO:0006310; GO:0006281; GO:0003723; GO:0005737; GO:0005730; GO:0000166 DNA binding; DNA recombination; DNA repair; RNA binding; cytoplasm; nucleolus; nucleotide binding IPR012677; IPR007232; IPR000504; RAD52 motif-containing protein 1 RDM1 Gallus gallus (Chicken) TR21588_c1_g1_i1 P43102 UBC4_CANAX 7.00E-07 GO:0005524; GO:0000209; GO:0004842 ATP binding; protein polyubiquitination; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 4 (EC 6.3.2.19) (Ubiquitin carrier protein 4) (Ubiquitin-protein ligase 4) UBC4 Candida albicans (Yeast) TR21588_c1_g2_i1 O88738 BIRC6_MOUSE 1.00E-55 GO:0005794; GO:0006915; GO:0051301; GO:0004869; GO:0005768; GO:0060711; GO:0016020; GO:0005815; GO:0030496; GO:0007067; GO:0043066; GO:0008284; GO:0032465; GO:0000922; GO:0060712; GO:0005802; GO:0004842 Golgi apparatus; apoptotic process; cell division; cysteine-type endopeptidase inhibitor activity; endosome; labyrinthine layer development; membrane; microtubule organizing center; midbody; mitosis; negative regulation of apoptotic process; positive regulation of cell proliferation; regulation of cytokinesis; spindle pole; spongiotrophoblast layer development; trans-Golgi network; ubiquitin-protein ligase activity IPR001370; IPR022103; IPR000608; IPR016135; IPR015943; IPR017986; Baculoviral IAP repeat-containing protein 6 (EC 6.3.2.-) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) Birc6 Kiaa1289 Mus musculus (Mouse) TR21588_c2_g1_i1 Q8K2Z8 UB2Q2_MOUSE 1.00E-09 GO:0005524; GO:0005737; GO:0070936; GO:0004842 ATP binding; cytoplasm; protein K48-linked ubiquitination; ubiquitin-protein ligase activity IPR006575; IPR000608; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin carrier protein Q2) (Ubiquitin-protein ligase Q2) Ube2q2 Mus musculus (Mouse) TR21594_c1_g1_i1 Q66H59 NPL_RAT 4.00E-52 GO:0019262; GO:0008747; GO:0005975; GO:0005737 N-acetylneuraminate catabolic process; N-acetylneuraminate lyase activity; carbohydrate metabolic process; cytoplasm IPR013785; IPR002220; Amino-sugar metabolism; N-acetylneuraminate degradation. N-acetylneuraminate lyase (NALase) (EC 4.1.3.3) (N-acetylneuraminate pyruvate-lyase) (N-acetylneuraminic acid aldolase) (Sialate lyase) (Sialate-pyruvate lyase) (Sialic acid aldolase) (Sialic acid lyase) Npl Rattus norvegicus (Rat) TR21597_c1_g2_i1 Q14767 LTBP2_HUMAN 6.00E-07 GO:0005509; GO:0005615; GO:0070062; GO:0008201; GO:0009306; GO:0006605; GO:0005578; GO:0007179 Q9UBX5 calcium ion binding; extracellular space; extracellular vesicular exosome; heparin binding; protein secretion; protein targeting; proteinaceous extracellular matrix; transforming growth factor beta receptor signaling pathway IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR017878; Latent-transforming growth factor beta-binding protein 2 (LTBP-2) LTBP2 C14orf141 LTBP3 Homo sapiens (Human) TR21597_c1_g3_i1 Q8IZU9 KIRR3_HUMAN 7.00E-10 GO:0030424; GO:0043198; GO:0005576; GO:0030097; GO:0016021; GO:0001764; GO:0005886; GO:0021740 axon; dendritic shaft; extracellular region; hemopoiesis; integral to membrane; neuron migration; plasma membrane; principal sensory nucleus of trigeminal nerve development IPR013162; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Kin of IRRE-like protein 3 (Kin of irregular chiasm-like protein 3) (Nephrin-like protein 2) KIRREL3 KIAA1867 NEPH2 UNQ5923/PRO4502/PRO19814 Homo sapiens (Human) TR21597_c1_g4_i1 Q8BR86 KIRR3_MOUSE 5.00E-10 GO:0030165; GO:0030424; GO:0043198; GO:0005576; GO:0030097; GO:0016021; GO:0001764; GO:0005886; GO:0021740 PDZ domain binding; axon; dendritic shaft; extracellular region; hemopoiesis; integral to membrane; neuron migration; plasma membrane; principal sensory nucleus of trigeminal nerve development IPR013162; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Kin of IRRE-like protein 3 (Kin of irregular chiasm-like protein 3) [Cleaved into: Processed kin of IRRE-like protein 3] Kirrel3 Kiaa1867 Mus musculus (Mouse) TR21597_c2_g1_i1 Q61851 FGFR3_MOUSE 1.00E-42 GO:0005524; GO:0000165; GO:0061144; GO:0060385; GO:0070977; GO:0060349; GO:0051216; GO:0022010; GO:0090102; GO:0016023; GO:0048546; GO:0005783; GO:0072148; GO:0017134; GO:1902178; GO:0005007; GO:0060113; GO:0005887; GO:0009898; GO:0070307; GO:0002089; GO:0005764; GO:0002009; GO:0048712; GO:0048640; GO:0050680; GO:0045839; GO:0045879; GO:0000122; GO:0048471; GO:0070374; GO:0090080; GO:0090263; GO:0045597; GO:0001938; GO:0043525; GO:0043552; GO:0010518; GO:0031398; GO:0042511; GO:0042517; GO:0036342; GO:0046777; GO:0048678; GO:0035019; GO:0021762 Q9JID9 ATP binding; MAPK cascade; alveolar secondary septum development; axonogenesis involved in innervation; bone maturation; bone morphogenesis; cartilage development; central nervous system myelination; cochlea development; cytoplasmic membrane-bounded vesicle; digestive tract morphogenesis; endoplasmic reticulum; epithelial cell fate commitment; fibroblast growth factor binding; fibroblast growth factor receptor signaling pathway involved in apoptotic process; fibroblast growth factor-activated receptor activity; inner ear receptor cell differentiation; integral to plasma membrane; internal side of plasma membrane; lens fiber cell development; lens morphogenesis in camera-type eye; lysosome; morphogenesis of an epithelium; negative regulation of astrocyte differentiation; negative regulation of developmental growth; negative regulation of epithelial cell proliferation; negative regulation of mitosis; negative regulation of smoothened signaling pathway; negative regulation of transcription from RNA polymerase II promoter; perinuclear region of cytoplasm; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell differentiation; positive regulation of endothelial cell proliferation; positive regulation of neuron apoptotic process; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phospholipase activity; positive regulation of protein ubiquitination; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tyrosine phosphorylation of Stat3 protein; post-anal tail morphogenesis; protein autophosphorylation; response to axon injury; somatic stem cell maintenance; substantia nigra development IPR028176; IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR013151; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (Heparin-binding growth factor receptor) (CD antigen CD333) Fgfr3 Mfr3 Sam3 Mus musculus (Mouse) TR21597_c2_g1_i2 Q9VBW3 CAD96_DROME 4.00E-53 GO:0005524; GO:0007030; GO:0005509; GO:0016339; GO:0007156; GO:0005887; GO:0045792; GO:0004713; GO:0004714 ATP binding; Golgi organization; calcium ion binding; calcium-dependent cell-cell adhesion; homophilic cell adhesion; integral to plasma membrane; negative regulation of cell size; protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity IPR002126; IPR015919; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14) Cad96Ca HD-14 CG10244 Drosophila melanogaster (Fruit fly) TR21597_c2_g2_i1 C0LGR3 Y4265_ARATH 5.00E-10 GO:0005524; GO:0016021; GO:0005886; GO:0004674 ATP binding; integral to membrane; plasma membrane; protein serine/threonine kinase activity IPR011009; IPR001611; IPR013210; IPR000719; IPR017441; IPR008271; Probable LRR receptor-like serine/threonine-protein kinase At4g26540 (EC 2.7.11.1) At4g26540 M3E9.30 Arabidopsis thaliana (Mouse-ear cress) TR21602_c0_g1_i1 P86855 PWAPL_MYTGA 3.00E-41 GO:0005576; GO:0010466; GO:0030414 extracellular region; negative regulation of peptidase activity; peptidase inhibitor activity IPR008197; Perlwapin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR21602_c0_g3_i1 P86855 PWAPL_MYTGA 8.00E-41 GO:0005576; GO:0010466; GO:0030414 extracellular region; negative regulation of peptidase activity; peptidase inhibitor activity IPR008197; Perlwapin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR21604_c2_g1_i1 Q9Z268 RASL1_MOUSE 2.00E-18 GO:0005099; GO:0005737; GO:0035556; GO:0031235; GO:0046872; GO:0046580; GO:0005543 Ras GTPase activator activity; cytoplasm; intracellular signal transduction; intrinsic to internal side of plasma membrane; metal ion binding; negative regulation of Ras protein signal transduction; phospholipid binding IPR000008; IPR011993; IPR001849; IPR001936; IPR023152; IPR008936; IPR001562; RasGAP-activating-like protein 1 Rasal1 Rasal Mus musculus (Mouse) TR21604_c5_g1_i1 Q9QYJ2 RASA3_RAT 2.00E-43 GO:0005099; GO:0005737; GO:0035556; GO:0031235; GO:0046872; GO:0046580; GO:0005543 Ras GTPase activator activity; cytoplasm; intracellular signal transduction; intrinsic to internal side of plasma membrane; metal ion binding; negative regulation of Ras protein signal transduction; phospholipid binding IPR000008; IPR011993; IPR001849; IPR001936; IPR023152; IPR008936; IPR001562; Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (R-ras GAP) Rasa3 Rattus norvegicus (Rat) TR21604_c6_g1_i1 P48423 GAP1_DROME 4.00E-37 GO:0005099; GO:0007265; GO:0008595; GO:0005737; GO:0016321; GO:0007476; GO:0031235; GO:0046872; GO:0007067; GO:0046580; GO:0005543; GO:0045678; GO:0007062; GO:0008293; GO:0007426 "Ras GTPase activator activity; Ras protein signal transduction; anterior/posterior axis specification, embryo; cytoplasm; female meiosis chromosome segregation; imaginal disc-derived wing morphogenesis; intrinsic to internal side of plasma membrane; metal ion binding; mitosis; negative regulation of Ras protein signal transduction; phospholipid binding; positive regulation of R7 cell differentiation; sister chromatid cohesion; torso signaling pathway; tracheal outgrowth, open tracheal system" IPR000008; IPR011993; IPR001849; IPR001936; IPR023152; IPR008936; IPR001562; GTPase-activating protein (Ras GTPase-activating protein) Gap1 CG6721 Drosophila melanogaster (Fruit fly) TR21609_c0_g1_i1 Q9D2G9 HIPL2_MOUSE 7.00E-11 GO:0005975; GO:0005576; GO:0016901; GO:0048038 "carbohydrate metabolic process; extracellular region; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor; quinone binding" IPR011042; IPR018143; IPR012938; IPR011041; HHIP-like protein 2 Hhipl2 Hhip3 Kiaa1822l Mus musculus (Mouse) TR21609_c0_g1_i2 Q7TN16 HHIP_MOUSE 6.00E-10 GO:0005975; GO:0009986; GO:0009953; GO:0060441; GO:0005576; GO:0005887; GO:0016525; GO:0045879; GO:0007405; GO:0016901; GO:0048038; GO:0040036; GO:0048705; GO:0007224; GO:0008270 "carbohydrate metabolic process; cell surface; dorsal/ventral pattern formation; epithelial tube branching involved in lung morphogenesis; extracellular region; integral to plasma membrane; negative regulation of angiogenesis; negative regulation of smoothened signaling pathway; neuroblast proliferation; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor; quinone binding; regulation of fibroblast growth factor receptor signaling pathway; skeletal system morphogenesis; smoothened signaling pathway; zinc ion binding" IPR011042; IPR000742; IPR013032; IPR018143; IPR012938; IPR011041; Hedgehog-interacting protein (HHIP) (HIP) Hhip Hip Mus musculus (Mouse) TR21611_c1_g1_i1 Q0AVU7 MOAC_SYNWW 2.00E-28 GO:0006777 Mo-molybdopterin cofactor biosynthetic process IPR023045; IPR023046; IPR002820; Cofactor biosynthesis; molybdopterin biosynthesis. Cyclic pyranopterin monophosphate synthase accessory protein (Molybdenum cofactor biosynthesis protein C) moaC Swol_1859 Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) TR21611_c1_g2_i1 A9AFU0 MOAC_BURM1 1.00E-30 GO:0006777 Mo-molybdopterin cofactor biosynthetic process IPR023045; IPR023046; IPR002820; Cofactor biosynthesis; molybdopterin biosynthesis. Cyclic pyranopterin monophosphate synthase accessory protein (Molybdenum cofactor biosynthesis protein C) moaC Bmul_0660 BMULJ_02600 Burkholderia multivorans (strain ATCC 17616 / 249) TR21611_c2_g1_i1 Q9NZB8 MOCS1_HUMAN 1.00E-171 GO:0051539; GO:0005525; GO:0006777; GO:0005829; GO:0016829; GO:0046872; GO:0019008; GO:0005634; GO:0006767 "4 iron, 4 sulfur cluster binding; GTP binding; Mo-molybdopterin cofactor biosynthetic process; cytosol; lyase activity; metal ion binding; molybdopterin synthase complex; nucleus; water-soluble vitamin metabolic process" IPR013785; IPR006638; IPR023045; IPR023046; IPR013483; IPR000385; IPR010505; IPR002820; IPR007197; Cofactor biosynthesis; molybdopterin biosynthesis. Molybdenum cofactor biosynthesis protein 1 (Cell migration-inducing gene 11 protein) (Molybdenum cofactor synthesis-step 1 protein A-B) [Includes: Cyclic pyranopterin monophosphate synthase (EC 4.1.99.18) (Molybdenum cofactor biosynthesis protein A); Cyclic pyranopterin monophosphate synthase accessory protein (Molybdenum cofactor biosynthesis protein C)] MOCS1 MIG11 Homo sapiens (Human) TR21621_c0_g1_i1 P55196 AFAD_HUMAN 2.00E-51 GO:0034332; GO:0045177; GO:0007155; GO:0034329; GO:0005913; GO:0005911; GO:0007267; GO:0005829; GO:0005634; GO:0005886; GO:0008022; GO:0007165 Q16643; Q92692; P12931 adherens junction organization; apical part of cell; cell adhesion; cell junction assembly; cell-cell adherens junction; cell-cell junction; cell-cell signaling; cytosol; nucleus; plasma membrane; protein C-terminus binding; signal transduction IPR018444; IPR002710; IPR000253; IPR001478; IPR000159; IPR008984; Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) MLLT4 AF6 Homo sapiens (Human) TR21622_c0_g1_i1 Q80V63 PRDM4_MOUSE 5.00E-19 GO:0003677; GO:0046872; GO:0008168; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; methyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001214; IPR007087; IPR015880; IPR013087; IPR017124; PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4) Prdm4 Mus musculus (Mouse) TR21622_c0_g1_i2 Q8C827 ZFP62_MOUSE 4.00E-16 GO:0046872; GO:0003676; GO:0005634; GO:0006355; GO:0006351 "metal ion binding; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 62 (Zfp-62) (ZT3) Zfp62 Mus musculus (Mouse) TR21624_c1_g1_i1 P21327 INPP_BOVIN 3.00E-08 GO:0004441; GO:0046872; GO:0046854 "inositol-1,4-bisphosphate 1-phosphatase activity; metal ion binding; phosphatidylinositol phosphorylation" IPR020583; IPR000760; IPR020550; Signal transduction; phosphatidylinositol signaling pathway. Inositol polyphosphate 1-phosphatase (IPP) (IPPase) (EC 3.1.3.57) INPP1 Bos taurus (Bovine) TR21624_c2_g1_i1 Q2YDR3 IMPA3_DANRE 2.00E-41 GO:0006021; GO:0008934; GO:0052832; GO:0052833; GO:0016021; GO:0046872; GO:0046854 inositol biosynthetic process; inositol monophosphate 1-phosphatase activity; inositol monophosphate 3-phosphatase activity; inositol monophosphate 4-phosphatase activity; integral to membrane; metal ion binding; phosphatidylinositol phosphorylation IPR000760; IPR020550; Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2. Inositol monophosphatase 3 (IMP 3) (IMPase 3) (EC 3.1.3.25) (Inositol monophosphatase domain-containing protein 1) (Inositol-1(or 4)-monophosphatase 3) (Myo-inositol monophosphatase A3) impad1 impa3 zgc:123256 Danio rerio (Zebrafish) (Brachydanio rerio) TR21627_c1_g1_i1 A6NHR9 SMHD1_HUMAN 5.00E-29 GO:0005524; GO:0001740; GO:0051276; GO:0060821 ATP binding; Barr body; chromosome organization; inactivation of X chromosome by DNA methylation IPR003594; IPR010935; Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) SMCHD1 KIAA0650 Homo sapiens (Human) TR21633_c0_g1_i1 Q9DG68 RLA0_RANSY 3.00E-150 GO:0005840; GO:0042254; GO:0003735; GO:0006414 ribosome; ribosome biogenesis; structural constituent of ribosome; translational elongation IPR001790; IPR001813; 60S acidic ribosomal protein P0 (60S ribosomal protein L10E) RPLP0 Rana sylvatica (Wood frog) TR21634_c3_g1_i1 Q4R6F2 CF070_MACFA 9.00E-10 GO:0016021 integral to membrane IPR025209; ER membrane-associated RNA degradation protein (Fragment) ERMARD QtsA-18153 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR21634_c3_g1_i2 Q5T6L9 CF070_HUMAN 9.00E-16 GO:0016021 integral to membrane IPR025209; ER membrane-associated RNA degradation protein ERMARD C6orf70 Homo sapiens (Human) TR21639_c0_g1_i1 O94915 FRYL_HUMAN 2.00E-19 GO:0006355; GO:0006351 Q16611; P31946; P61981 "regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011989; IPR016024; IPR025614; IPR025481; Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) FRYL AF4P12 KIAA0826 Homo sapiens (Human) TR21639_c1_g1_i1 Q5TBA9 FRY_HUMAN 4.00E-17 GO:0005737; GO:0005815; GO:0000922 cytoplasm; microtubule organizing center; spindle pole IPR016024; IPR025614; IPR025481; Protein furry homolog FRY C13orf14 Homo sapiens (Human) TR21641_c2_g1_i1 Q7TSA6 CS055_MOUSE 1.00E-10 Uncharacterized protein C19orf55 homolog Mus musculus (Mouse) TR21646_c0_g1_i1 Q9MYM7 B3GT1_PONPY 1.00E-47 GO:0000139; GO:0008378; GO:0016021; GO:0006486 Golgi membrane; galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) TR21652_c0_g1_i2 P19801 ABP1_HUMAN 3.00E-22 GO:0009308; GO:0005509; GO:0097185; GO:0071280; GO:0035874; GO:0071504; GO:0071420; GO:0005507; GO:0052597; GO:0008144; GO:0005615; GO:0008201; GO:0052598; GO:0052599; GO:0005777; GO:0005886; GO:0008131; GO:0052600; GO:0032403; GO:0048038; GO:0004872; GO:0046677; GO:0042493; GO:0005272; GO:0005923; GO:0008270 "amine metabolic process; calcium ion binding; cellular response to azide; cellular response to copper ion; cellular response to copper ion starvation; cellular response to heparin; cellular response to histamine; copper ion binding; diamine oxidase activity; drug binding; extracellular space; heparin binding; histamine oxidase activity; methylputrescine oxidase activity; peroxisome; plasma membrane; primary amine oxidase activity; propane-1,3-diamine oxidase activity; protein complex binding; quinone binding; receptor activity; response to antibiotic; response to drug; sodium channel activity; tight junction; zinc ion binding" IPR000269; IPR015798; IPR016182; IPR015800; IPR015801; IPR015802; Amiloride-sensitive amine oxidase [copper-containing] (DAO) (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase) (Kidney amine oxidase) (KAO) AOC1 ABP1 DAO1 Homo sapiens (Human) TR21654_c1_g1_i1 Q4AE62 GTDC1_HUMAN 1.00E-85 GO:0009058; GO:0016757 "biosynthetic process; transferase activity, transferring glycosyl groups" IPR001296; IPR022701; Glycosyltransferase-like domain-containing protein 1 (Mat-Xa) GTDC1 Homo sapiens (Human) TR21657_c0_g3_i1 Q7TNS2 MOS1_MOUSE 2.00E-30 GO:0016021; GO:0005743; GO:0005739 integral to membrane; mitochondrial inner membrane; mitochondrion IPR007512; Mitochondrial inner membrane organizing system protein 1 Minos1 Mus musculus (Mouse) TR21659_c0_g1_i1 Q4V9P6 ADAL_DANRE 4.00E-125 GO:0019239; GO:0016787; GO:0046872; GO:0009117; GO:0009168 deaminase activity; hydrolase activity; metal ion binding; nucleotide metabolic process; purine ribonucleoside monophosphate biosynthetic process IPR001365; Adenosine deaminase-like protein (EC 3.5.4.-) adal zgc:109912 Danio rerio (Zebrafish) (Brachydanio rerio) TR21660_c0_g1_i1 A4QNG1 CC167_XENTR 5.00E-06 GO:0016021 integral to membrane IPR028194; Coiled-coil domain-containing protein 167 ccdc167 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR21665_c0_g1_i1 Q4R5L5 ANXA7_MACFA 3.00E-20 GO:0005509; GO:0005544 calcium ion binding; calcium-dependent phospholipid binding IPR001464; IPR018502; IPR018252; IPR013286; Annexin A7 (Annexin VII) (Annexin-7) ANXA7 QccE-14346 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR21665_c1_g1_i1 P50994 ANXA4_CANFA 8.00E-10 GO:0005509; GO:0005544 calcium ion binding; calcium-dependent phospholipid binding IPR001464; IPR018502; IPR018252; IPR002391; Annexin A4 (36 kDa zymogen granule membrane-associated protein) (ZAP36) (Annexin IV) (Annexin-4) (Lipocortin IV) ANXA4 ANX4 Canis familiaris (Dog) (Canis lupus familiaris) TR21668_c2_g1_i1 P51513 NOVA1_HUMAN 9.00E-06 GO:0003723; GO:0008380; GO:0007626; GO:0003729; GO:0000398; GO:0005634; GO:0007268 "RNA binding; RNA splicing; locomotory behavior; mRNA binding; mRNA splicing, via spliceosome; nucleus; synaptic transmission" IPR004087; IPR004088; RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Onconeural ventral antigen 1) (Paraneoplastic Ri antigen) (Ventral neuron-specific protein 1) NOVA1 Homo sapiens (Human) TR21669_c0_g3_i1 A7Y2W8 SC6A9_XENLA 6.00E-27 GO:0005887; GO:0005328; GO:0005283 integral to plasma membrane; neurotransmitter:sodium symporter activity; sodium:amino acid symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9) slc6a9 glyt1 Xenopus laevis (African clawed frog) TR21673_c1_g1_i1 P16524 PATA_BACSU 4.00E-09 GO:0005737; GO:0019877; GO:0009089; GO:0030170; GO:0008483 cytoplasm; diaminopimelate biosynthetic process; lysine biosynthetic process via diaminopimelate; pyridoxal phosphate binding; transaminase activity IPR004839; IPR004838; IPR015424; IPR015421; IPR015422; "Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 2/3." Putative N-acetyl-LL-diaminopimelate aminotransferase (EC 2.6.1.-) (Putative aminotransferase A) patA uat BSU14000 Bacillus subtilis (strain 168) TR21678_c0_g1_i1 P54412 EF1G_CAEEL 3.00E-50 GO:0005853; GO:0003746 eukaryotic translation elongation factor 1 complex; translation elongation factor activity IPR010987; IPR004046; IPR012336; IPR001662; Probable elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) F17C11.9 Caenorhabditis elegans TR21678_c0_g2_i1 P26641 EF1G_HUMAN 3.00E-98 GO:0005829; GO:0005853; GO:0009615; GO:0003746 P24534; P29692; Q969Q1 cytosol; eukaryotic translation elongation factor 1 complex; response to virus; translation elongation factor activity IPR010987; IPR004045; IPR004046; IPR012336; IPR001662; Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) EEF1G EF1G PRO1608 Homo sapiens (Human) TR21681_c0_g1_i1 Q3IBX5 CDD_PSEHT 1.00E-06 GO:0004126; GO:0008270 cytidine deaminase activity; zinc ion binding IPR016192; IPR002125; IPR013171; IPR006263; IPR016193; IPR020797; Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) (CDA) cdd PSHAb0315 Pseudoalteromonas haloplanktis (strain TAC 125) TR21681_c0_g1_i3 P32320 CDD_HUMAN 6.00E-44 GO:0007166; GO:0004126; GO:0019858; GO:0005829; GO:0005576; GO:0030308; GO:0045980; GO:0001882; GO:0042803; GO:0051289; GO:0043097; GO:0008270 cell surface receptor signaling pathway; cytidine deaminase activity; cytosine metabolic process; cytosol; extracellular region; negative regulation of cell growth; negative regulation of nucleotide metabolic process; nucleoside binding; protein homodimerization activity; protein homotetramerization; pyrimidine nucleoside salvage; zinc ion binding IPR016192; IPR002125; IPR006262; IPR016193; Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) CDA CDD Homo sapiens (Human) TR21684_c0_g1_i1 Q17QH8 D39U1_BOVIN 6.00E-106 GO:0016491 oxidoreductase activity IPR013549; IPR016040; IPR010099; Epimerase family protein SDR39U1 (EC 1.1.1.-) (Short-chain dehydrogenase/reductase family 39U member 1) SDR39U1 Bos taurus (Bovine) TR21686_c3_g1_i1 Q54BA2 Y3800_DICDI 8.00E-10 IPR002110; IPR020683; IPR001487; IPR018359; IPR000210; IPR011333; IPR013069; IPR027353; "Ankyrin repeat, bromo and BTB domain-containing protein DDB_G0293800" DDB_G0293800 Dictyostelium discoideum (Slime mold) TR21687_c1_g1_i1 O43301 HS12A_HUMAN 4.00E-19 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR21687_c2_g3_i1 Q9HB20 PKHA3_HUMAN 6.00E-10 GO:0005545; GO:0005794; GO:0016020; GO:0005543 1-phosphatidylinositol binding; Golgi apparatus; membrane; phospholipid binding IPR011993; IPR001849; Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1) PLEKHA3 FAPP1 Homo sapiens (Human) TR21687_c3_g1_i1 O97125 HSP68_DROME 9.00E-06 GO:0005524; GO:0008340; GO:0005811; GO:0005875; GO:0022008; GO:0031427; GO:0042594 ATP binding; determination of adult lifespan; lipid particle; microtubule associated complex; neurogenesis; response to methotrexate; response to starvation IPR018181; IPR013126; Heat shock protein 68 Hsp68 CG5436 Drosophila melanogaster (Fruit fly) TR21689_c1_g1_i1 Q80W31 ZN569_MOUSE 5.00E-35 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 569 (Mszf21) (Zinc finger protein 74) (Zfp-74) Znf569 Zfp74 Mus musculus (Mouse) TR21690_c0_g2_i1 Q75A26 ARF_ASHGO 6.00E-40 GO:0006888; GO:0005525; GO:0005794; GO:0006893; GO:0016236; GO:0015031; GO:0007264 ER to Golgi vesicle-mediated transport; GTP binding; Golgi apparatus; Golgi to plasma membrane transport; macroautophagy; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor ARF1 ADR094W Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR21692_c0_g1_i1 P02637 SCP_MIZYE 2.00E-13 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Sarcoplasmic calcium-binding protein (SCP) Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) TR21702_c1_g1_i1 Q5MCW4 ZN569_HUMAN 5.00E-40 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 569 ZNF569 Homo sapiens (Human) TR21704_c0_g1_i1 P86854 PLCL_MYTGA 4.00E-11 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR21705_c0_g1_i1 Q86IV5 CTNA_DICDI 3.00E-23 GO:0030041; GO:0006928; GO:0005576; GO:0042593; GO:0007275; GO:0031158; GO:0030827; GO:0007162; GO:0032114; GO:0006110; GO:0004871 actin filament polymerization; cellular component movement; extracellular region; glucose homeostasis; multicellular organismal development; negative regulation of aggregate size involved in sorocarp development; negative regulation of cGMP biosynthetic process; negative regulation of cell adhesion; regulation of glucose-6-phosphatase activity; regulation of glycolysis; signal transducer activity IPR008139; Countin-1 ctnA DDB_G0274597 Dictyostelium discoideum (Slime mold) TR21719_c1_g1_i1 Q66H30 GIN1_RAT 1.00E-07 GO:0015074; GO:0003676 DNA integration; nucleic acid binding IPR001584; IPR012337; IPR015416; Gypsy retrotransposon integrase-like protein 1 (GIN-1) GIN1 Rattus norvegicus (Rat) TR21722_c0_g1_i1 Q2IBD7 CAV1_PONAB 9.00E-27 GO:0000139; GO:0031295; GO:0016324; GO:0097190; GO:0016323; GO:0005901; GO:0072584; GO:0071455; GO:0009267; GO:0031410; GO:0051480; GO:0005768; GO:0030514; GO:0090090; GO:0033137; GO:0032091; GO:0000122; GO:0010524; GO:0090263; GO:2001238; GO:2001244; GO:0033138; GO:2000286; GO:0030193; GO:0051592; GO:0032570; GO:0005198; GO:0016050 Golgi membrane; T cell costimulation; apical plasma membrane; apoptotic signaling pathway; basolateral plasma membrane; caveola; caveolin-mediated endocytosis; cellular response to hyperoxia; cellular response to starvation; cytoplasmic vesicle; cytosolic calcium ion homeostasis; endosome; negative regulation of BMP signaling pathway; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of peptidyl-serine phosphorylation; negative regulation of protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of calcium ion transport into cytosol; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of peptidyl-serine phosphorylation; receptor internalization involved in canonical Wnt receptor signaling pathway; regulation of blood coagulation; response to calcium ion; response to progesterone stimulus; structural molecule activity; vesicle organization IPR001612; IPR015504; IPR018361; Caveolin-1 CAV1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR21724_c0_g2_i1 Q9W5D4 POMT2_DROME 4.00E-15 GO:0004169; GO:0005783; GO:0005789; GO:0016021; GO:0030259; GO:0016203; GO:0035269; GO:0045214; GO:0007525 dolichyl-phosphate-mannose-protein mannosyltransferase activity; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; lipid glycosylation; muscle attachment; protein O-linked mannosylation; sarcomere organization; somatic muscle development IPR027005; IPR003342; IPR016093; Protein modification; protein glycosylation. Protein O-mannosyl-transferase 2 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 2) (DmPOMT2) (dPOMT2) (Protein twisted) tw Pomt2 CG12311 Drosophila melanogaster (Fruit fly) TR21726_c0_g1_i1 Q13422 IKZF1_HUMAN 5.00E-12 GO:0030183; GO:0003677; GO:0048541; GO:0030217; GO:0007049; GO:0005721; GO:0016568; GO:0005737; GO:0030900; GO:0048732; GO:0048535; GO:0007498; GO:0046872; GO:0001779; GO:0000122; GO:0003676; GO:0005634; GO:0051138; GO:0040018; GO:0045660; GO:0045944; GO:0060041; GO:0043565; GO:0003700; GO:0048538; GO:0006351 "B cell differentiation; DNA binding; Peyer's patch development; T cell differentiation; cell cycle; centromeric heterochromatin; chromatin modification; cytoplasm; forebrain development; gland development; lymph node development; mesoderm development; metal ion binding; natural killer cell differentiation; negative regulation of transcription from RNA polymerase II promoter; nucleic acid binding; nucleus; positive regulation of NK T cell differentiation; positive regulation of multicellular organism growth; positive regulation of neutrophil differentiation; positive regulation of transcription from RNA polymerase II promoter; retina development in camera-type eye; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; thymus development; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) IKZF1 IK1 IKAROS LYF1 ZNFN1A1 Homo sapiens (Human) TR21726_c0_g1_i2 Q14590 ZN235_HUMAN 4.00E-27 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) TR21730_c1_g1_i1 Q8NHV1 GIMA7_HUMAN 2.00E-19 GO:0005525; GO:0003924; GO:0005811 GTP binding; GTPase activity; lipid particle IPR006703; IPR027417; GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) TR21732_c0_g1_i1 P86854 PLCL_MYTGA 1.00E-13 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR21732_c0_g2_i1 P86854 PLCL_MYTGA 1.00E-13 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR21735_c1_g1_i1 O95954 FTCD_HUMAN 5.00E-70 GO:0005794; GO:0005814; GO:0007010; GO:0005829; GO:0005542; GO:0006760; GO:0030412; GO:0030409; GO:0006548; GO:0019556; GO:0019557; GO:0035999 Golgi apparatus; centriole; cytoskeleton organization; cytosol; folic acid binding; folic acid-containing compound metabolic process; formimidoyltetrahydrofolate cyclodeaminase activity; glutamate formimidoyltransferase activity; histidine catabolic process; histidine catabolic process to glutamate and formamide; histidine catabolic process to glutamate and formate; tetrahydrofolate interconversion IPR007044; IPR013802; IPR004227; IPR012886; IPR022384; Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1. One-carbon metabolism; tetrahydrofolate interconversion. Formimidoyltransferase-cyclodeaminase (Formiminotransferase-cyclodeaminase) (FTCD) (LCHC1) [Includes: Glutamate formimidoyltransferase (EC 2.1.2.5) (Glutamate formiminotransferase) (Glutamate formyltransferase); Formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) (Formiminotetrahydrofolate cyclodeaminase)] FTCD Homo sapiens (Human) TR21737_c1_g1_i1 P55918 MFAP4_BOVIN 5.00E-39 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR014716; IPR014715; IPR002181; Microfibril-associated glycoprotein 4 (36 kDa microfibril-associated glycoprotein) (36 kDa MAP) MFAP4 Bos taurus (Bovine) TR21739_c0_g1_i1 Q91W10 S39A8_MOUSE 7.00E-14 GO:0016021; GO:0046873; GO:0031090; GO:0006829 integral to membrane; metal ion transmembrane transporter activity; organelle membrane; zinc ion transport IPR003689; Zinc transporter ZIP8 (Solute carrier family 39 member 8) (Zrt- and Irt-like protein 8) (ZIP-8) Slc39a8 Zip8 Mus musculus (Mouse) TR21741_c1_g1_i1 Q95Q95 TOR_CAEEL 2.00E-08 GO:0016303; GO:0005524; GO:0031929; GO:0031931; GO:0031932; GO:0000492; GO:0005737; GO:0008340; GO:0008144; GO:0002119; GO:0005634; GO:0045727; GO:0004674 1-phosphatidylinositol-3-kinase activity; ATP binding; TOR signaling cascade; TORC1 complex; TORC2 complex; box C/D snoRNP assembly; cytoplasm; determination of adult lifespan; drug binding; nematode larval development; nucleus; positive regulation of translation; protein serine/threonine kinase activity IPR011989; IPR016024; IPR024585; IPR003152; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR009076; IPR026683; Target of rapamycin homolog (EC 2.7.11.1) (CeTOR) (Lethal protein 363) let-363 tor B0261.2 Caenorhabditis elegans TR21741_c2_g1_i1 P32600 TOR2_YEAST 6.00E-11 GO:0004430; GO:0005524; GO:0031929; GO:0031931; GO:0031932; GO:0030037; GO:0008144; GO:0030950; GO:0031234; GO:0000329; GO:0010507; GO:2001108; GO:0035025; GO:0045807; GO:0004674; GO:0051726; GO:0001558; GO:0042254 Q08236; Q04749; P47041; P41318; Q04372; P40061 1-phosphatidylinositol 4-kinase activity; ATP binding; TOR signaling cascade; TORC1 complex; TORC2 complex; actin filament reorganization involved in cell cycle; drug binding; establishment or maintenance of actin cytoskeleton polarity; extrinsic to internal side of plasma membrane; fungal-type vacuole membrane; negative regulation of autophagy; positive regulation of Rho guanyl-nucleotide exchange factor activity; positive regulation of Rho protein signal transduction; positive regulation of endocytosis; protein serine/threonine kinase activity; regulation of cell cycle; regulation of cell growth; ribosome biogenesis IPR011989; IPR016024; IPR024585; IPR003152; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR009076; IPR026683; Serine/threonine-protein kinase TOR2 (EC 2.7.1.67) (EC 2.7.11.1) (Dominant rapamycin resistance protein 2) (Phosphatidylinositol 4-kinase TOR2) (PI4-kinase TOR2) (PI4K TOR2) (PtdIns-4-kinase TOR2) (Target of rapamycin kinase 2) (Temperature-sensitive CSG2 suppressor protein 14) TOR2 DRR2 TSC14 YKL203C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR21741_c3_g1_i1 P42346 MTOR_RAT 2.00E-57 GO:0005524; GO:0000082; GO:0000139; GO:0016605; GO:0001030; GO:0001031; GO:0001032; GO:0031929; GO:0031931; GO:0031932; GO:0030030; GO:0071456; GO:0031669; GO:0005829; GO:0008144; GO:0005789; GO:0007281; GO:0005764; GO:0070438; GO:0005741; GO:0051534; GO:0010507; GO:0045792; GO:0016242; GO:0005634; GO:0018105; GO:0018107; GO:0030838; GO:0001938; GO:0010592; GO:0046889; GO:0010831; GO:0050731; GO:0051897; GO:0051496; GO:0045945; GO:0045727; GO:0046777; GO:0004674; GO:0032314; GO:0043610; GO:0031998; GO:0005979; GO:0045859; GO:0032095; GO:0043200; GO:0032868; GO:0043022; GO:0031529 Q8TB45 ATP binding; G1/S transition of mitotic cell cycle; Golgi membrane; PML body; RNA polymerase III type 1 promoter DNA binding; RNA polymerase III type 2 promoter DNA binding; RNA polymerase III type 3 promoter DNA binding; TOR signaling cascade; TORC1 complex; TORC2 complex; cell projection organization; cellular response to hypoxia; cellular response to nutrient levels; cytosol; drug binding; endoplasmic reticulum membrane; germ cell development; lysosome; mTOR-FKBP12-rapamycin complex; mitochondrial outer membrane; negative regulation of NFAT protein import into nucleus; negative regulation of autophagy; negative regulation of cell size; negative regulation of macroautophagy; nucleus; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of actin filament polymerization; positive regulation of endothelial cell proliferation; positive regulation of lamellipodium assembly; positive regulation of lipid biosynthetic process; positive regulation of myotube differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of stress fiber assembly; positive regulation of transcription from RNA polymerase III promoter; positive regulation of translation; protein autophosphorylation; protein serine/threonine kinase activity; regulation of Rac GTPase activity; regulation of carbohydrate utilization; regulation of fatty acid beta-oxidation; regulation of glycogen biosynthetic process; regulation of protein kinase activity; regulation of response to food; response to amino acid stimulus; response to insulin stimulus; ribosome binding; ruffle organization IPR011989; IPR016024; IPR024585; IPR003152; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR009076; IPR026683; IPR011990; Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin target protein 1) (RAPT1) Mtor Frap1 Raft1 Rattus norvegicus (Rat) TR21745_c1_g1_i1 Q94CI6 EDL18_ARATH 2.00E-07 GO:0008643; GO:0016021; GO:0022891 carbohydrate transport; integral to membrane; substrate-specific transmembrane transporter activity IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; Sugar transporter ERD6-like 18 (Sugar-porter family protein 2) SFP2 At5g27360 F21A20.70 Arabidopsis thaliana (Mouse-ear cress) TR21745_c2_g1_i1 Q5J316 GTR12_BOVIN 4.00E-19 GO:0008643; GO:0012505; GO:0016021; GO:0022891 carbohydrate transport; endomembrane system; integral to membrane; substrate-specific transmembrane transporter activity IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 12 (Glucose transporter type 12) (GLUT-12)" SLC2A12 GLUT12 Bos taurus (Bovine) TR21745_c2_g1_i2 Q0P4G6 GTR10_XENTR 8.00E-18 GO:0008643; GO:0012505; GO:0016021; GO:0048471; GO:0022891 carbohydrate transport; endomembrane system; integral to membrane; perinuclear region of cytoplasm; substrate-specific transmembrane transporter activity IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 10 (Glucose transporter type 10) (GLUT-10)" slc2a10 glut10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR21745_c3_g1_i1 Q8BFW9 GTR12_MOUSE 1.00E-21 GO:0012505; GO:0015758; GO:0016021; GO:0016020; GO:0022891 endomembrane system; glucose transport; integral to membrane; membrane; substrate-specific transmembrane transporter activity IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 12 (Glucose transporter type 12) (GLUT-12)" Slc2a12 Glut12 Glut8 Mus musculus (Mouse) TR21747_c0_g1_i1 P11118 CALM_EUGGR 2.00E-23 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Euglena gracilis TR21755_c0_g1_i1 Q95218 DMBT1_RABIT 3.00E-09 GO:0030154; GO:0005576; GO:0019898; GO:0007275; GO:0015031; GO:0005044; GO:0035375; GO:0042589 cell differentiation; extracellular region; extrinsic to membrane; multicellular organismal development; protein transport; scavenger receptor activity; zymogen binding; zymogen granule membrane IPR000859; IPR001190; IPR017448; IPR001507; IPR017977; Deleted in malignant brain tumors 1 protein (Hensin) Dmbt1 Oryctolagus cuniculus (Rabbit) TR21757_c1_g1_i1 Q26474 LACH_SCHAM 9.00E-07 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Lachesin LAC Schistocerca americana (American grasshopper) TR21758_c0_g1_i1 P43699 NKX21_HUMAN 1.00E-57 GO:0060486; GO:0033327; GO:0003705; GO:0060510; GO:0048646; GO:0007411; GO:0021892; GO:0021795; GO:0031128; GO:0007492; GO:0060441; GO:0021798; GO:0021877; GO:0021759; GO:0021766; GO:0007626; GO:0060430; GO:0042696; GO:0030336; GO:0010719; GO:0000122; GO:0030512; GO:0001764; GO:0005654; GO:0048709; GO:0006644; GO:0021983; GO:0045944; GO:0009725; GO:0043565; GO:0003700; GO:0030878; GO:0005667; GO:0044212 Q9P031; P16333 Clara cell differentiation; Leydig cell differentiation; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; Type II pneumocyte differentiation; anatomical structure formation involved in morphogenesis; axon guidance; cerebral cortex GABAergic interneuron differentiation; cerebral cortex cell migration; developmental induction; endoderm development; epithelial tube branching involved in lung morphogenesis; forebrain dorsal/ventral pattern formation; forebrain neuron fate commitment; globus pallidus development; hippocampus development; locomotory behavior; lung saccule development; menarche; negative regulation of cell migration; negative regulation of epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; neuron migration; nucleoplasm; oligodendrocyte differentiation; phospholipid metabolic process; pituitary gland development; positive regulation of transcription from RNA polymerase II promoter; response to hormone stimulus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; thyroid gland development; transcription factor complex; transcription regulatory region DNA binding IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein Nkx-2.1 (Homeobox protein NK-2 homolog A) (Thyroid nuclear factor 1) (Thyroid transcription factor 1) (TTF-1) NKX2-1 NKX2A TITF1 TTF1 Homo sapiens (Human) TR21759_c0_g1_i1 Q9WVJ4 SYJ2B_RAT 1.00E-13 GO:0009986; GO:0031307; GO:0048312; GO:0032926; GO:0032927; GO:2000010; GO:0002092 O55207-3 cell surface; integral to mitochondrial outer membrane; intracellular distribution of mitochondria; negative regulation of activin receptor signaling pathway; positive regulation of activin receptor signaling pathway; positive regulation of protein localization to cell surface; positive regulation of receptor internalization IPR001478; Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25) (NPW16) Synj2bp Omp25 Rattus norvegicus (Rat) TR21759_c0_g2_i1 Q5ZIK2 PDZ11_CHICK 3.00E-10 GO:0016323; GO:0005829; GO:0008022 basolateral plasma membrane; cytosol; protein C-terminus binding IPR001478; PDZ domain-containing protein 11 PDZD11 PDZK11 RCJMB04_25h3 Gallus gallus (Chicken) TR21759_c1_g1_i1 Q8BH75 RNF41_MOUSE 4.00E-07 GO:0005128; GO:0097191; GO:0005135; GO:0030336; GO:0008285; GO:0000209; GO:0031386; GO:0043408; GO:0045619; GO:0045637; GO:0051896; GO:2000377; GO:0004842; GO:0008270 erythropoietin receptor binding; extrinsic apoptotic signaling pathway; interleukin-3 receptor binding; negative regulation of cell migration; negative regulation of cell proliferation; protein polyubiquitination; protein tag; regulation of MAPK cascade; regulation of lymphocyte differentiation; regulation of myeloid cell differentiation; regulation of protein kinase B signaling cascade; regulation of reactive oxygen species metabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR013323; IPR008974; IPR015036; IPR018957; IPR001841; IPR013083; IPR017907; IPR013010; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase NRDP1 (EC 6.3.2.-) (RING finger protein 41) Rnf41 Flrf Nrdp1 Mus musculus (Mouse) TR21759_c1_g2_i1 Q6FPI4 RAD18_CANGA 6.00E-08 GO:0006281; GO:0003684; GO:0005634; GO:0005778; GO:0016558; GO:0004842; GO:0008270 DNA repair; damaged DNA binding; nucleus; peroxisomal membrane; protein import into peroxisome matrix; ubiquitin-protein ligase activity; zinc ion binding IPR004580; IPR003034; IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Postreplication repair E3 ubiquitin-protein ligase RAD18 (EC 6.3.2.-) RAD18 CAGL0J03586g Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) TR21759_c1_g3_i1 Q8N448 LNX2_HUMAN 3.00E-91 GO:0051260; GO:0008270 P09022 protein homooligomerization; zinc ion binding IPR001478; IPR018957; IPR001841; IPR013083; IPR017907; Ligand of Numb protein X 2 (Numb-binding protein 2) (PDZ domain-containing RING finger protein 1) LNX2 PDZRN1 Homo sapiens (Human) TR21764_c0_g1_i1 P56597 NDK5_HUMAN 2.00E-102 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0003351; GO:0043066; GO:0004550; GO:0009116; GO:0036126; GO:0007286; GO:0021591 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; epithelial cilium movement; negative regulation of apoptotic process; nucleoside diphosphate kinase activity; nucleoside metabolic process; sperm flagellum; spermatid development; ventricular system development IPR007858; IPR012410; IPR001564; Nucleoside diphosphate kinase homolog 5 (NDK-H 5) (NDP kinase homolog 5) (Inhibitor of p53-induced apoptosis-beta) (IPIA-beta) (Testis-specific nm23 homolog) (nm23-H5) NME5 Homo sapiens (Human) TR21765_c0_g1_i1 Q14656 TM187_HUMAN 1.00E-35 GO:0016021; GO:0030133 integral to membrane; transport vesicle IPR028066; Transmembrane protein 187 (Protein ITBA1) TMEM187 CXorf12 DXS9878E ITBA1 Homo sapiens (Human) TR21766_c0_g1_i1 Q5BIM1 TRI45_BOVIN 2.00E-06 GO:0005737; GO:0005634; GO:0008270 cytoplasm; nucleus; zinc ion binding IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) TR21769_c0_g2_i2 A2ASS6 TITIN_MOUSE 2.00E-07 GO:0005524; GO:0031430; GO:0030018; GO:0007512; GO:0055003; GO:0043056; GO:0003007; GO:0001701; GO:0046872; GO:0006936; GO:0005859; GO:0005634; GO:0018108; GO:0004674; GO:0004713; GO:1901897; GO:0045214; GO:0001756; GO:0005200 ATP binding; M band; Z disc; adult heart development; cardiac myofibril assembly; forward locomotion; heart morphogenesis; in utero embryonic development; metal ion binding; muscle contraction; muscle myosin complex; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of relaxation of cardiac muscle; sarcomere organization; somitogenesis; structural constituent of cytoskeleton IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) TR21772_c0_g1_i1 Q9LS44 PCR4_ARATH 5.00E-11 GO:0016021 integral to membrane IPR006461; Protein PLANT CADMIUM RESISTANCE 4 (AtPCR4) PCR4 At3g18460 MYF24.18 Arabidopsis thaliana (Mouse-ear cress) TR21773_c0_g1_i1 P55112 NAS4_CAEEL 2.00E-44 GO:0005576; GO:0004222; GO:0006508; GO:0008270 extracellular region; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR001506; IPR006026; Zinc metalloproteinase nas-4 (EC 3.4.24.21) (Nematode astacin 4) nas-4 C05D11.6 Caenorhabditis elegans TR21777_c1_g1_i1 Q95ZJ1 GALT5_CAEEL 1.00E-12 GO:0000139; GO:0016021; GO:0004653; GO:0018243 Golgi membrane; integral to membrane; polypeptide N-acetylgalactosaminyltransferase activity; protein O-linked glycosylation via threonine IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 5 (pp-GaNTase 5) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5) gly-5 Y39E4B.12 Caenorhabditis elegans TR21779_c0_g1_i1 Q13263 TIF1B_HUMAN 1.00E-06 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR21781_c1_g1_i1 Q32L96 PHIPL_BOVIN 2.00E-29 GO:0005737 cytoplasm IPR003961; IPR013783; Phytanoyl-CoA hydroxylase interacting protein-like PHYHIPL Bos taurus (Bovine) TR21783_c1_g1_i1 Q9I927 FUCL5_ANGJA 8.00E-07 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-5 Anguilla japonica (Japanese eel) TR21783_c1_g2_i1 Q9I926 FUCL6_ANGJA 1.00E-07 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-6 Anguilla japonica (Japanese eel) TR21789_c0_g1_i1 Q96RT1 LAP2_HUMAN 1.00E-17 GO:0005176; GO:0009925; GO:0045175; GO:0005604; GO:0007155; GO:0007049; GO:0016049; GO:0005737; GO:0007173; GO:0045197; GO:0030056; GO:0007229; GO:0045104; GO:0031965; GO:0005634; GO:0006605; GO:0005200 Q99569 ErbB-2 class receptor binding; basal plasma membrane; basal protein localization; basement membrane; cell adhesion; cell cycle; cell growth; cytoplasm; epidermal growth factor receptor signaling pathway; establishment or maintenance of epithelial cell apical/basal polarity; hemidesmosome; integrin-mediated signaling pathway; intermediate filament cytoskeleton organization; nuclear membrane; nucleus; protein targeting; structural constituent of cytoskeleton IPR001611; IPR025875; IPR001478; Protein LAP2 (Densin-180-like protein) (Erbb2-interacting protein) (Erbin) ERBB2IP ERBIN KIAA1225 LAP2 Homo sapiens (Human) TR21789_c0_g1_i2 Q9DBG9 TX1B3_MOUSE 5.00E-09 GO:0007266; GO:0016055; GO:0032864; GO:0005737; GO:0030178; GO:0008285; GO:2000009; GO:0005634; GO:0005886 Q02248 Rho protein signal transduction; Wnt receptor signaling pathway; activation of Cdc42 GTPase activity; cytoplasm; negative regulation of Wnt receptor signaling pathway; negative regulation of cell proliferation; negative regulation of protein localization to cell surface; nucleus; plasma membrane IPR001478; IPR017268; Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) Tax1bp3 Mus musculus (Mouse) TR21789_c0_g1_i3 Q09506 YQI7_CAEEL 8.00E-10 GO:0030111 G5EF99 regulation of Wnt receptor signaling pathway IPR001478; IPR017268; Uncharacterized protein C45G9.7 C45G9.7 Caenorhabditis elegans TR21790_c0_g1_i1 A6QQZ0 GDAP1_BOVIN 1.00E-34 GO:0031307; GO:0000266; GO:0006626; GO:0032526 integral to mitochondrial outer membrane; mitochondrial fission; protein targeting to mitochondrion; response to retinoic acid IPR010987; IPR004045; IPR012336; Ganglioside-induced differentiation-associated protein 1 (GDAP1) GDAP1 Bos taurus (Bovine) TR21791_c0_g1_i1 Q24157 BRN_DROME 7.00E-08 GO:0000139; GO:0005795; GO:0007219; GO:0046981; GO:0007298; GO:0005576; GO:0047915; GO:0007293; GO:0006688; GO:0008314; GO:0016021; GO:0042248; GO:0001744; GO:0007299; GO:0006486 "Golgi membrane; Golgi stack; Notch signaling pathway; beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity; border follicle cell migration; extracellular region; ganglioside galactosyltransferase activity; germarium-derived egg chamber formation; glycosphingolipid biosynthetic process; gurken receptor signaling pathway; integral to membrane; maintenance of polarity of follicular epithelium; optic lobe placode formation; ovarian follicle cell-cell adhesion; protein glycosylation" IPR002659; "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) TR21792_c0_g1_i1 Q9QUS6 TRIM1_MOUSE 1.00E-09 GO:0005813; GO:0005737; GO:0016874; GO:0005874; GO:0016567; GO:0008270 centrosome; cytoplasm; ligase activity; microtubule; protein ubiquitination; zinc ion binding IPR001870; IPR003649; IPR003879; IPR008985; IPR017903; IPR003961; IPR013783; IPR027727; IPR018355; IPR003877; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase MID2 (EC 6.3.2.-) (Midline defect 2) (Midline-2) (Tripartite motif-containing protein 1) Mid2 Fxy2 Trim1 Mus musculus (Mouse) TR21792_c1_g1_i1 Q29RQ5 TRIM9_BOVIN 2.00E-75 GO:0030054; GO:0005737; GO:0005856; GO:0030425; GO:0043161; GO:0008021; GO:0004842; GO:0008270 cell junction; cytoplasm; cytoskeleton; dendrite; proteasomal ubiquitin-dependent protein catabolic process; synaptic vesicle; ubiquitin-protein ligase activity; zinc ion binding IPR001870; IPR003649; IPR008985; IPR017903; IPR003961; IPR013783; IPR003877; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM9 (EC 6.3.2.-) (Tripartite motif-containing protein 9) TRIM9 Bos taurus (Bovine) TR21795_c0_g1_i1 Q4ZHR9 GCYB1_CANFA 0 GO:0005525; GO:0005737; GO:0004383; GO:0020037; GO:0035556; GO:0046872 GTP binding; cytoplasm; guanylate cyclase activity; heme binding; intracellular signal transduction; metal ion binding IPR001054; IPR018297; IPR011645; IPR011644; IPR024096; Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit) GUCY1B3 Canis familiaris (Dog) (Canis lupus familiaris) TR21797_c1_g1_i1 Q2NKJ3 CTC1_HUMAN 5.00E-13 GO:0070188; GO:0048539; GO:0071425; GO:0035264; GO:0045740; GO:0048146; GO:0010389; GO:0090399; GO:0006974; GO:0003697; GO:0048536; GO:0000723; GO:0010833; GO:0048538 Q9H668 Stn1-Ten1 complex; bone marrow development; hematopoietic stem cell proliferation; multicellular organism growth; positive regulation of DNA replication; positive regulation of fibroblast proliferation; regulation of G2/M transition of mitotic cell cycle; replicative senescence; response to DNA damage stimulus; single-stranded DNA binding; spleen development; telomere maintenance; telomere maintenance via telomere lengthening; thymus development CST complex subunit CTC1 (Conserved telomere maintenance component 1) (HBV DNAPTP1-transactivated protein B) CTC1 C17orf68 Homo sapiens (Human) TR21798_c0_g1_i1 Q5R9J9 TPPC4_PONAB 2.00E-105 GO:0006888; GO:0005795; GO:0030008; GO:0005801; GO:0030425; GO:0016358; GO:0005783; GO:0008021 ER to Golgi vesicle-mediated transport; Golgi stack; TRAPP complex; cis-Golgi network; dendrite; dendrite development; endoplasmic reticulum; synaptic vesicle IPR011012; IPR007233; Trafficking protein particle complex subunit 4 TRAPPC4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR21799_c0_g2_i2 Q9DAR0 CE049_MOUSE 2.00E-21 IPR027901; Uncharacterized protein C5orf49 homolog (Y regulated sperm protein) Mus musculus (Mouse) TR21808_c0_g1_i1 P30975 TLR2_DROME 3.00E-48 GO:0005887; GO:0004995 integral to plasma membrane; tachykinin receptor activity IPR000276; IPR017452; IPR001681; Tachykinin-like peptides receptor 99D (dTKR) Takr99D CG7887 Drosophila melanogaster (Fruit fly) TR21816_c1_g1_i1 Q04202 TCB2_CAEBR 2.00E-21 GO:0003677; GO:0015074; GO:0005634; GO:0004803; GO:0006313 "DNA binding; DNA integration; nucleus; transposase activity; transposition, DNA-mediated" IPR002492; Transposable element Tcb2 transposase Caenorhabditis briggsae TR21821_c0_g1_i1 Q9D1I5 MCEE_MOUSE 4.00E-64 GO:0046491; GO:0004493; GO:0005739 L-methylmalonyl-CoA metabolic process; methylmalonyl-CoA epimerase activity; mitochondrion IPR017515; "Methylmalonyl-CoA epimerase, mitochondrial (EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)" Mcee Mus musculus (Mouse) TR21823_c0_g1_i1 Q9QZS7 NPHN_MOUSE 6.00E-11 GO:0007254; GO:0007155; GO:0042995; GO:0032836; GO:0072015; GO:0005887; GO:0007520; GO:0030838; GO:0044062; GO:0007519; GO:0036057 JNK cascade; cell adhesion; cell projection; glomerular basement membrane development; glomerular visceral epithelial cell development; integral to plasma membrane; myoblast fusion; positive regulation of actin filament polymerization; regulation of excretion; skeletal muscle tissue development; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Mus musculus (Mouse) TR21826_c2_g1_i1 P97587 CGRF1_RAT 7.00E-19 GO:0007050; GO:0030308; GO:0005634; GO:0008270 cell cycle arrest; negative regulation of cell growth; nucleus; zinc ion binding IPR001841; IPR013083; Cell growth regulator with RING finger domain protein 1 (Cell growth regulatory gene 19 protein) Cgrrf1 Cgr19 Rattus norvegicus (Rat) TR21829_c0_g1_i1 P0C7N0 RWDD3_RAT 9.00E-38 GO:0005737; GO:0005634 cytoplasm; nucleus IPR010541; IPR006575; IPR016135; RWD domain-containing protein 3 (RWD domain-containing sumoylation enhancer) (RSUME) Rwdd3 Rattus norvegicus (Rat) TR21834_c0_g1_i1 Q9YGQ1 EF1B_CHICK 1.00E-37 GO:0005853; GO:0003746 eukaryotic translation elongation factor 1 complex; translation elongation factor activity IPR018940; IPR010987; IPR014717; IPR001326; IPR014038; Elongation factor 1-beta (EF-1-beta) EEF1B Gallus gallus (Chicken) TR21836_c0_g1_i1 Q92010 ZF161_CHICK 4.00E-15 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 5) (ZF5) ZBTB14 ZFP161 Gallus gallus (Chicken) TR21836_c2_g1_i1 Q03172 ZEP1_MOUSE 8.00E-08 GO:0003677; GO:0046872; GO:0000122; GO:0005634; GO:0006351 P63085 "DNA binding; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 40 (Alpha A-crystallin-binding protein 1) (Alpha A-CRYBP1) (Alpha A-crystallin-binding protein I) (Transcription factor alphaA-CRYBP1) Hivep1 Cryabp1 Znf40 Mus musculus (Mouse) TR21840_c0_g1_i1 Q8BZ20 PAR12_MOUSE 3.00E-17 GO:0003950; GO:0046872; GO:0005634 NAD+ ADP-ribosyltransferase activity; metal ion binding; nucleus IPR012317; IPR004170; IPR000571; Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) Parp12 Zc3hdc1 Mus musculus (Mouse) TR21842_c0_g1_i1 Q76B49 CD63_FELCA 2.00E-31 GO:0009986; GO:0034613; GO:0016021; GO:0031902; GO:0005765; GO:0005886; GO:2000680 cell surface; cellular protein localization; integral to membrane; late endosome membrane; lysosomal membrane; plasma membrane; regulation of rubidium ion transport IPR000301; IPR018499; IPR018503; IPR008952; CD63 antigen (CD antigen CD63) CD63 Felis catus (Cat) (Felis silvestris catus) TR21843_c0_g1_i1 P0CK98 CCD39_DANRE 4.00E-31 GO:0070286; GO:0060285; GO:0035085; GO:0005856; GO:0060287 axonemal dynein complex assembly; ciliary cell motility; cilium axoneme; cytoskeleton; epithelial cilium movement involved in determination of left/right asymmetry Coiled-coil domain-containing protein 39 (Fragment) ccdc39 Danio rerio (Zebrafish) (Brachydanio rerio) TR21843_c2_g2_i1 Q0V9R4 CCD39_XENTR 1.00E-78 GO:0070286; GO:0060285; GO:0035085; GO:0005856; GO:0060287 axonemal dynein complex assembly; ciliary cell motility; cilium axoneme; cytoskeleton; epithelial cilium movement involved in determination of left/right asymmetry IPR023139 Coiled-coil domain-containing protein 39 ccdc39 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR21844_c2_g1_i1 P97798 NEO1_MOUSE 5.00E-11 GO:0045296; GO:0007155; GO:0016021; GO:0007520; GO:0005886; GO:0004872; GO:0006355 F8VQB6 "cadherin binding; cell adhesion; integral to membrane; myoblast fusion; plasma membrane; receptor activity; regulation of transcription, DNA-dependent" IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR010560; Neogenin Neo1 Ngn Mus musculus (Mouse) TR21845_c0_g2_i1 O16025 AOSL_PLEHO 3.00E-09 GO:0047677; GO:0019369; GO:0004096; GO:0005737; GO:0020037; GO:0047987; GO:0005506; GO:0016020; GO:0031408 arachidonate 8(R)-lipoxygenase activity; arachidonic acid metabolic process; catalase activity; cytoplasm; heme binding; hydroperoxide dehydratase activity; iron ion binding; membrane; oxylipin biosynthetic process IPR020835; IPR011614; IPR008976; IPR000907; IPR013819; IPR020834; IPR020833; IPR001885; IPR001024; Lipid metabolism; arachidonate metabolism. Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (EC 4.2.1.92) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)] Plexaura homomalla (Black sea rod) TR21845_c1_g1_i1 Q02759 LX12L_RAT 3.00E-07 GO:0043277; GO:0004052; GO:0050473; GO:0019369; GO:0030282; GO:0035963; GO:0005829; GO:0019395; GO:0051120; GO:0051122; GO:0047977; GO:0005506; GO:0005811; GO:2001303; GO:0019372; GO:0002820; GO:0043066; GO:0045794; GO:0006646; GO:0070374; GO:0030838; GO:0030307; GO:0008284; GO:0010811; GO:0034116; GO:0019870; GO:1901074; GO:0042391; GO:0035358; GO:0034976; GO:0042383; GO:0042060 apoptotic cell clearance; arachidonate 12-lipoxygenase activity; arachidonate 15-lipoxygenase activity; arachidonic acid metabolic process; bone mineralization; cellular response to interleukin-13; cytosol; fatty acid oxidation; hepoxilin A3 synthase activity; hepoxilin biosynthetic process; hepoxilin-epoxide hydrolase activity; iron ion binding; lipid particle; lipoxin A4 biosynthetic process; lipoxygenase pathway; negative regulation of adaptive immune response; negative regulation of apoptotic process; negative regulation of cell volume; phosphatidylethanolamine biosynthetic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of actin filament polymerization; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cell-substrate adhesion; positive regulation of heterotypic cell-cell adhesion; potassium channel inhibitor activity; regulation of engulfment of apoptotic cell; regulation of membrane potential; regulation of peroxisome proliferator activated receptor signaling pathway; response to endoplasmic reticulum stress; sarcolemma; wound healing IPR008976; IPR000907; IPR013819; IPR020834; IPR020833; IPR001885; IPR001024; Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis. "Arachidonate 15-lipoxygenase (15-LOX) (EC 1.13.11.33) (12/15-lipoxygenase) (Arachidonate 12-lipoxygenase, leukocyte-type) (12-LOX) (EC 1.13.11.31) (Arachidonate omega-6 lipoxygenase)" Alox15 Alox12l Rattus norvegicus (Rat) TR21846_c2_g1_i1 Q24192 RHOL_DROME 1.00E-22 GO:0005525; GO:0003924; GO:0007298; GO:0005509; GO:0007155; GO:0007516; GO:0035099; GO:0005622; GO:0035011; GO:0007498; GO:0005886; GO:0022409; GO:0008360; GO:0006974; GO:0007264 GTP binding; GTPase activity; border follicle cell migration; calcium ion binding; cell adhesion; hemocyte development; hemocyte migration; intracellular; melanotic encapsulation of foreign target; mesoderm development; plasma membrane; positive regulation of cell-cell adhesion; regulation of cell shape; response to DNA damage stimulus; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Ras-like GTP-binding protein RhoL RhoL Drac3 CG9366 Drosophila melanogaster (Fruit fly) TR21848_c0_g1_i1 Q7PPA5 ATC1_ANOGA 2.00E-178 GO:0005524; GO:0005388; GO:0016021; GO:0046872; GO:0033017 ATP binding; calcium-transporting ATPase activity; integral to membrane; metal ion binding; sarcoplasmic reticulum membrane IPR005782; IPR006068; IPR004014; IPR023299; IPR018303; IPR023298; IPR008250; IPR001757; IPR023214; Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type (EC 3.6.3.8) (Calcium pump) Ca-P60A AGAP006186 Anopheles gambiae (African malaria mosquito) TR21856_c0_g1_i1 Q9WVB4 SLIT3_MOUSE 6.00E-12 GO:0035385; GO:0061364; GO:0048846; GO:0007411; GO:0005509; GO:0032870; GO:0005615; GO:0050919; GO:0030308; GO:0008285; GO:0070100; GO:0010629; GO:0009887; GO:0005102; GO:0051414 Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; axon guidance; calcium ion binding; cellular response to hormone stimulus; extracellular space; negative chemotaxis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of chemokine-mediated signaling pathway; negative regulation of gene expression; organ morphogenesis; receptor binding; response to cortisol stimulus IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 3 protein (Slit-3) (Slit3) Slit3 Mus musculus (Mouse) TR21856_c1_g2_i1 Q6P1C6 LRIG3_MOUSE 2.00E-06 GO:0030659; GO:0016021; GO:0007275; GO:0005886 cytoplasmic vesicle membrane; integral to membrane; multicellular organismal development; plasma membrane IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR025875; IPR003591; IPR000372; Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) Lrig3 Kiaa3016 Mus musculus (Mouse) TR21857_c1_g1_i1 P02594 CALM_ELEEL 1.00E-44 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) calm Electrophorus electricus (Electric eel) TR21857_c1_g1_i2 O01305 CAVP_BRAFL 9.00E-09 GO:0005509; GO:0005737 calcium ion binding; cytoplasm IPR011992; IPR018247; IPR002048; IPR001125; Calcium vector protein (CAVP) Branchiostoma floridae (Florida lancelet) (Amphioxus) TR21857_c1_g1_i3 P24044 CALM_PLAFA 3.00E-43 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) Plasmodium falciparum TR21859_c1_g1_i1 A0JM23 NPHP3_XENTR 1.00E-22 GO:0016055; GO:0060271; GO:0090090; GO:0072372; GO:2000095 "Wnt receptor signaling pathway; cilium morphogenesis; negative regulation of canonical Wnt receptor signaling pathway; primary cilium; regulation of Wnt receptor signaling pathway, planar cell polarity pathway" IPR027417; IPR013026; IPR011990; IPR019734; Nephrocystin-3 nphp3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR21860_c1_g1_i1 O15973 OPSD1_MIZYE 4.00E-16 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR000856; IPR027430; "Rhodopsin, GQ-coupled (GQ-rhodopsin)" SCOP1 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) TR21862_c1_g2_i1 Q8WXI2 CNKR2_HUMAN 9.00E-23 GO:0005737; GO:0043005; GO:0043025; GO:0005543; GO:0045211; GO:0009966 cytoplasm; neuron projection; neuronal cell body; phospholipid binding; postsynaptic membrane; regulation of signal transduction IPR010599; IPR017874; IPR019555; IPR001478; IPR011993; IPR001849; IPR001660; IPR013761; IPR021129; Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) CNKSR2 CNK2 KIAA0902 KSR2 Homo sapiens (Human) TR21863_c2_g1_i1 Q8N1F8 S11IP_HUMAN 6.00E-09 GO:0005765; GO:0008104 lysosomal membrane; protein localization IPR001611; Serine/threonine-protein kinase 11-interacting protein (LKB1-interacting protein 1) STK11IP KIAA1898 LIP1 LKB1IP STK11IP1 Homo sapiens (Human) TR21866_c2_g1_i1 Q5ZIW1 PEO1_CHICK 2.00E-16 GO:0043139; GO:0005524; GO:0006264; GO:0042645; GO:0003697 5'-3' DNA helicase activity; ATP binding; mitochondrial DNA replication; mitochondrial nucleoid; single-stranded DNA binding IPR007694; IPR027417; IPR027032; "Twinkle protein, mitochondrial (EC 3.6.4.12) (Progressive external ophthalmoplegia 1 protein homolog)" PEO1 RCJMB04_23c24 Gallus gallus (Chicken) TR21868_c1_g1_i1 Q761V0 SC6A5_MOUSE 2.00E-16 GO:0016021; GO:0005328 integral to membrane; neurotransmitter:sodium symporter activity IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) Slc6a5 Glyt2 Mus musculus (Mouse) TR21869_c0_g1_i1 A4FUD4 PEX12_BOVIN 2.00E-99 GO:0005779; GO:0007031; GO:0016558; GO:0008270 integral to peroxisomal membrane; peroxisome organization; protein import into peroxisome matrix; zinc ion binding IPR017375; IPR006845; IPR001841; IPR013083; Peroxisome assembly protein 12 (Peroxin-12) PEX12 Bos taurus (Bovine) TR21871_c0_g1_i2 P56719 OX2R_RAT 1.00E-17 GO:0022410; GO:0007631; GO:0016021; GO:0007218; GO:0016499; GO:0017046; GO:0007200; GO:0005886 circadian sleep/wake cycle process; feeding behavior; integral to membrane; neuropeptide signaling pathway; orexin receptor activity; peptide hormone binding; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane IPR000276; IPR017452; IPR000204; IPR004060; Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Rattus norvegicus (Rat) TR21872_c0_g1_i1 Q78P75 DYL2_RAT 3.00E-58 GO:0005813; GO:0005737; GO:0008092; GO:0030286; GO:0005874; GO:0007017; GO:0003774; GO:0016459; GO:0008039; GO:0006810 centrosome; cytoplasm; cytoskeletal protein binding; dynein complex; microtubule; microtubule-based process; motor activity; myosin complex; synaptic target recognition; transport IPR019763; IPR001372; "Dynein light chain 2, cytoplasmic (Dynein light chain LC8-type 2)" Dynll2 Dlc2 Rattus norvegicus (Rat) TR21877_c0_g1_i1 Q5VWZ2 LYPL1_HUMAN 2.00E-66 GO:0005829; GO:0004622; GO:0042997; GO:0002084 cytosol; lysophospholipase activity; negative regulation of Golgi to plasma membrane protein transport; protein depalmitoylation IPR003140; Lysophospholipase-like protein 1 (EC 3.1.2.-) LYPLAL1 Homo sapiens (Human) TR21879_c1_g1_i1 O60568 PLOD3_HUMAN 6.00E-30 GO:0031418; GO:0070831; GO:0006464; GO:0032870; GO:0030199; GO:0005789; GO:0001886; GO:0048730; GO:0030198; GO:0001701; GO:0005506; GO:0060425; GO:0021915; GO:0050211; GO:0033823; GO:0008475; GO:0008104; GO:0030867; GO:0042311 Q9BQY4 L-ascorbic acid binding; basement membrane assembly; cellular protein modification process; cellular response to hormone stimulus; collagen fibril organization; endoplasmic reticulum membrane; endothelial cell morphogenesis; epidermis morphogenesis; extracellular matrix organization; in utero embryonic development; iron ion binding; lung morphogenesis; neural tube development; procollagen galactosyltransferase activity; procollagen glucosyltransferase activity; procollagen-lysine 5-dioxygenase activity; protein localization; rough endoplasmic reticulum membrane; vasodilation IPR005123; IPR006620; IPR001006; "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3)" PLOD3 Homo sapiens (Human) TR21879_c3_g1_i1 O60568 PLOD3_HUMAN 5.00E-45 GO:0031418; GO:0070831; GO:0006464; GO:0032870; GO:0030199; GO:0005789; GO:0001886; GO:0048730; GO:0030198; GO:0001701; GO:0005506; GO:0060425; GO:0021915; GO:0050211; GO:0033823; GO:0008475; GO:0008104; GO:0030867; GO:0042311 Q9BQY4 L-ascorbic acid binding; basement membrane assembly; cellular protein modification process; cellular response to hormone stimulus; collagen fibril organization; endoplasmic reticulum membrane; endothelial cell morphogenesis; epidermis morphogenesis; extracellular matrix organization; in utero embryonic development; iron ion binding; lung morphogenesis; neural tube development; procollagen galactosyltransferase activity; procollagen glucosyltransferase activity; procollagen-lysine 5-dioxygenase activity; protein localization; rough endoplasmic reticulum membrane; vasodilation IPR005123; IPR006620; IPR001006; "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3)" PLOD3 Homo sapiens (Human) TR21880_c0_g1_i1 Q9VQ62 NPC2_DROME 7.00E-10 GO:0045456; GO:0005615; GO:0030882; GO:0001530; GO:0070891; GO:0042834; GO:0061057; GO:0055092; GO:0015918; GO:0008039 Q9VPU1 ecdysteroid biosynthetic process; extracellular space; lipid antigen binding; lipopolysaccharide binding; lipoteichoic acid binding; peptidoglycan binding; peptidoglycan recognition protein signaling pathway; sterol homeostasis; sterol transport; synaptic target recognition IPR014756; IPR003172; Protein NPC2 homolog (Niemann Pick type C2 protein homolog) Npc2a NPC2 CG7291 Drosophila melanogaster (Fruit fly) TR21883_c0_g1_i1 O95905 SGT1_HUMAN 7.00E-20 GO:0008283; GO:0005737; GO:0005634; GO:2000045; GO:0006110; GO:0006355; GO:0003713; GO:0006366 P08238; P63208 "cell proliferation; cytoplasm; nucleus; regulation of G1/S transition of mitotic cell cycle; regulation of glycolysis; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription from RNA polymerase II promoter" IPR010770; Protein SGT1 (hSGT1) (Protein ecdysoneless homolog) (Suppressor of GCR2) ECD SGT1 Homo sapiens (Human) TR21883_c1_g1_i1 Q9LSM5 SGT1_ARATH 1.00E-12 Q0Q0I7 IPR010770; Protein SGT1 homolog At5g65490 At5g65490 K19O4.2 Arabidopsis thaliana (Mouse-ear cress) TR21884_c2_g1_i1 Q0PMG2 MDGA1_MOUSE 2.00E-13 GO:0046658; GO:0021799; GO:0001764 anchored to plasma membrane; cerebral cortex radially oriented cell migration; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 Mdga1 Mus musculus (Mouse) TR21884_c4_g1_i1 Q5VYJ5 CJ112_HUMAN 5.00E-10 GO:0016021 integral to membrane IPR008985; IPR023415; IPR002172; IPR000998; MAM and LDL-receptor class A domain-containing protein C10orf112 C10orf112 Homo sapiens (Human) TR21886_c0_g1_i1 Q9DBV3 DHX34_MOUSE 8.00E-27 GO:0005524; GO:0008026; GO:0003723 ATP binding; ATP-dependent helicase activity; RNA binding IPR011545; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; IPR015880; Probable ATP-dependent RNA helicase DHX34 (EC 3.6.4.13) (DEAH box protein 34) Dhx34 Ddx34 Kiaa0134 Mus musculus (Mouse) TR21887_c2_g1_i1 Q3USF0 B3GN6_MOUSE 1.00E-10 GO:0000139; GO:0008378; GO:0016021; GO:0006486 Golgi membrane; galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (BGnT-6) (Beta-1,3-Gn-T6) (Beta-1,3-N-acetylglucosaminyltransferase 6) (Beta3Gn-T6) (EC 2.4.1.-) (Core 3 synthase)" B3gnt6 Mus musculus (Mouse) TR21887_c3_g1_i1 Q9Z0F0 B3GT4_MOUSE 4.00E-17 GO:0000139; GO:0047915; GO:0016021; GO:0006486 Golgi membrane; ganglioside galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 4 (Beta-1,3-GalTase 4) (Beta3Gal-T4) (Beta3GalT4) (b3Gal-T4) (EC 2.4.1.62) (Gal-T2) (Ganglioside galactosyltransferase) (UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase)" B3galt4 Mus musculus (Mouse) TR21888_c0_g1_i1 Q8N2A0 CX062_HUMAN 5.00E-19 Putative uncharacterized protein encoded by LINC00269 LINC00269 CXorf62 NCRNA00269 Homo sapiens (Human) TR21888_c0_g1_i2 Q8WTZ3 YS049_HUMAN 8.00E-18 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR013087; Zinc finger protein ENSP00000375192 Homo sapiens (Human) TR21890_c2_g1_i1 Q92954 PRG4_HUMAN 5.00E-12 GO:0008283; GO:0005615; GO:0071425; GO:0006955; GO:0045409; GO:0030247; GO:0042127; GO:0005044 cell proliferation; extracellular space; hematopoietic stem cell proliferation; immune response; negative regulation of interleukin-6 biosynthetic process; polysaccharide binding; regulation of cell proliferation; scavenger receptor activity IPR000585; IPR018487; IPR018486; IPR020436; IPR001212; Proteoglycan 4 (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Cleaved into: Proteoglycan 4 C-terminal part] PRG4 MSF SZP Homo sapiens (Human) TR21891_c1_g1_i1 Q8K4C0 FMO5_RAT 2.00E-21 GO:0004499; GO:0050661; GO:0005789; GO:0050660; GO:0016021 "N,N-dimethylaniline monooxygenase activity; NADP binding; endoplasmic reticulum membrane; flavin adenine dinucleotide binding; integral to membrane" IPR012143; IPR000960; IPR020946; IPR002257; IPR016040; Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5) Fmo5 Rattus norvegicus (Rat) TR21891_c1_g1_i2 Q9FWW9 GSXL2_ARATH 2.00E-11 GO:0004499; GO:0050661; GO:0050832; GO:0050660 "N,N-dimethylaniline monooxygenase activity; NADP binding; defense response to fungus; flavin adenine dinucleotide binding" IPR000960; IPR020946; Flavin-containing monooxygenase FMO GS-OX-like 2 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 2) At1g12200 T28K15.7 Arabidopsis thaliana (Mouse-ear cress) TR21896_c1_g1_i1 Q9P2Y4 ZN219_HUMAN 1.00E-07 GO:0003677; GO:0004969; GO:0016021; GO:0046872; GO:0045892; GO:0005634; GO:0001505; GO:0003700; GO:0006351 "DNA binding; histamine receptor activity; integral to membrane; metal ion binding; negative regulation of transcription, DNA-dependent; nucleus; regulation of neurotransmitter levels; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR003980; IPR007087; IPR015880; IPR013087; Zinc finger protein 219 ZNF219 Homo sapiens (Human) TR21896_c2_g1_i1 A0JNB1 ZN227_BOVIN 2.00E-43 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 227 ZNF227 Bos taurus (Bovine) TR21896_c3_g1_i1 A6NJL1 ZSA5B_HUMAN 2.00E-31 GO:0003677; GO:0046872; GO:0005634; GO:0000981 DNA binding; metal ion binding; nucleus; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 5B ZSCAN5B Homo sapiens (Human) TR21900_c1_g1_i1 O15232 MATN3_HUMAN 8.00E-06 GO:0030198; GO:0005201; GO:0005578; GO:0001501 extracellular matrix organization; extracellular matrix structural constituent; proteinaceous extracellular matrix; skeletal system development IPR000742; IPR013032; IPR009030; IPR019466; IPR002035; Matrilin-3 MATN3 Homo sapiens (Human) TR21903_c1_g1_i1 Q6J5K9 ARMI_DROME 9.00E-14 GO:0005524; GO:0003678; GO:0016246; GO:0070725; GO:0030424; GO:0005737; GO:0030425; GO:0046843; GO:0007616; GO:0031023; GO:0043025; GO:0000184; GO:0007318; GO:0045202 Q9W4W2; Q9VKM1 "ATP binding; DNA helicase activity; RNA interference; Yb body; axon; cytoplasm; dendrite; dorsal appendage formation; long-term memory; microtubule organizing center organization; neuronal cell body; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; pole plasm protein localization; synapse" IPR028327; IPR027417; Probable RNA helicase armi (EC 3.6.4.13) (Protein armitage) armi CG11513 Drosophila melanogaster (Fruit fly) TR21903_c2_g1_i1 Q9BYK8 PR285_HUMAN 4.00E-59 GO:0005524; GO:0003677; GO:0044255; GO:0004386; GO:0030374; GO:0046872; GO:0005654; GO:0045944; GO:0044281; GO:0006351 "ATP binding; DNA binding; cellular lipid metabolic process; helicase activity; ligand-dependent nuclear receptor transcription coactivator activity; metal ion binding; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; small molecule metabolic process; transcription, DNA-dependent" IPR003593; IPR026122; IPR012340; IPR027417; IPR022966; IPR015880; "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) TR21904_c0_g1_i1 Q66KB9 BL1S2_XENTR 3.00E-39 GO:0031083; GO:0008089; GO:0048490; GO:0005813; GO:0031175; GO:0005634; GO:0045944 BLOC-1 complex; anterograde axon cargo transport; anterograde synaptic vesicle transport; centrosome; neuron projection development; nucleus; positive regulation of transcription from RNA polymerase II promoter IPR019269; Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC-1 subunit 2) bloc1s2 TTpA018b22.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR21905_c3_g1_i1 Q9NUV9 GIMA4_HUMAN 6.00E-08 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR21908_c0_g1_i1 O43315 AQP9_HUMAN 2.00E-46 GO:0005275; GO:0016323; GO:0015722; GO:0046943; GO:0071320; GO:0007588; GO:0015254; GO:0006955; GO:0005887; GO:0043231; GO:0008152; GO:0015288; GO:0005345; GO:0005350; GO:0046689; GO:0006970; GO:0015250; GO:0030104 amine transmembrane transporter activity; basolateral plasma membrane; canalicular bile acid transport; carboxylic acid transmembrane transporter activity; cellular response to cAMP; excretion; glycerol channel activity; immune response; integral to plasma membrane; intracellular membrane-bounded organelle; metabolic process; porin activity; purine nucleobase transmembrane transporter activity; pyrimidine nucleobase transmembrane transporter activity; response to mercury ion; response to osmotic stress; water channel activity; water homeostasis IPR023271; IPR015685; IPR000425; IPR022357; Aquaporin-9 (AQP-9) (Aquaglyceroporin-9) (Small solute channel 1) AQP9 SSC1 Homo sapiens (Human) TR21910_c0_g1_i1 P39057 DYHC_ANTCR 3.00E-160 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein beta chain, ciliary" Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR21912_c0_g1_i1 Q5RDZ2 CRYL1_PONAB 4.00E-80 GO:0003857; GO:0050104; GO:0070403; GO:0005829; GO:0006631 3-hydroxyacyl-CoA dehydrogenase activity; L-gulonate 3-dehydrogenase activity; NAD+ binding; cytosol; fatty acid metabolic process IPR022694; IPR006180; IPR006176; IPR006108; IPR008927; IPR013328; IPR016040; Lambda-crystallin homolog (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) (Gul3DH) CRYL1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR21913_c0_g1_i1 Q9VE46 SC5A7_DROME 6.00E-20 GO:0008292; GO:0015171; GO:0015220; GO:0016021; GO:0006814; GO:0015293 acetylcholine biosynthetic process; amino acid transmembrane transporter activity; choline transmembrane transporter activity; integral to membrane; sodium ion transport; symporter activity IPR001734; High-affinity choline transporter 1 CG7708 Drosophila melanogaster (Fruit fly) TR21917_c0_g1_i1 Q920G2 NHRF2_RAT 6.00E-13 GO:0030165; GO:0016324; GO:0016247; GO:0005737; GO:0012505; GO:0048839; GO:0005634; GO:0045838; GO:0043234; GO:0032947 O35240 PDZ domain binding; apical plasma membrane; channel regulator activity; cytoplasm; endomembrane system; inner ear development; nucleus; positive regulation of membrane potential; protein complex; protein complex scaffold IPR015098; IPR017300; IPR001478; Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1) Slc9a3r2 Nherf2 Rattus norvegicus (Rat) TR21917_c0_g2_i1 A8MUH7 PDZ1P_HUMAN 8.00E-09 IPR001478; Putative PDZ domain-containing protein 1P PDZK1P1; PDZK1P2 Homo sapiens (Human) TR21921_c0_g1_i1 Q9NH13 RP43_RIFPA 2.00E-14 GO:0006033; GO:0030198 chitin localization; extracellular matrix organization IPR000859; Exoskeleton protein RP43 Riftia pachyptila (Vent tube worm) TR21921_c0_g2_i1 Q8BUJ9 LRP12_MOUSE 3.00E-25 GO:0005905; GO:0006897; GO:0005887 coated pit; endocytosis; integral to plasma membrane IPR000859; IPR023415; IPR002172; Low-density lipoprotein receptor-related protein 12 (LRP-12) Lrp12 Mus musculus (Mouse) TR21921_c1_g1_i1 Q7RTY7 OVCH1_HUMAN 3.00E-63 GO:0005576; GO:0046872; GO:0006508; GO:0004252 extracellular region; metal ion binding; proteolysis; serine-type endopeptidase activity IPR000859; IPR001254; IPR018114; IPR001314; IPR009003; Ovochymase-1 (EC 3.4.21.-) OVCH1 Homo sapiens (Human) TR21927_c0_g2_i1 Q92902 HPS1_HUMAN 1.00E-10 GO:0007596; GO:0016023; GO:0048069; GO:0005887; GO:0005764; GO:0007040; GO:0030318; GO:0032816; GO:0060041; GO:0033299; GO:0007601 Q9NQG7 blood coagulation; cytoplasmic membrane-bounded vesicle; eye pigmentation; integral to plasma membrane; lysosome; lysosome organization; melanocyte differentiation; positive regulation of natural killer cell activation; retina development in camera-type eye; secretion of lysosomal enzymes; visual perception IPR026053; Hermansky-Pudlak syndrome 1 protein HPS1 HPS Homo sapiens (Human) TR21930_c0_g1_i1 Q07120 GFI1_RAT 1.00E-18 GO:0071222; GO:0010956; GO:0010977; GO:0000122; GO:0016604; GO:0016363; GO:0070105; GO:0034121; GO:0044212; GO:0006351; GO:0017053; GO:0008270 Q96KQ7 "cellular response to lipopolysaccharide; negative regulation of calcidiol 1-monooxygenase activity; negative regulation of neuron projection development; negative regulation of transcription from RNA polymerase II promoter; nuclear body; nuclear matrix; positive regulation of interleukin-6-mediated signaling pathway; regulation of toll-like receptor signaling pathway; transcription regulatory region DNA binding; transcription, DNA-dependent; transcriptional repressor complex; zinc ion binding" IPR007087; IPR015880; IPR013087; IPR001878; Zinc finger protein Gfi-1 (Growth factor independent protein 1) Gfi1 Gfi-1 Rattus norvegicus (Rat) TR21934_c0_g1_i1 Q9P0L1 ZN167_HUMAN 2.00E-38 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein with KRAB and SCAN domains 7 (Zinc finger protein 167) (Zinc finger protein 448) (Zinc finger protein 64) ZKSCAN7 ZNF167 ZNF448 ZNF64 Homo sapiens (Human) TR21937_c2_g1_i1 Q86TL2 TM110_HUMAN 6.00E-24 GO:0016021 integral to membrane IPR022127; Transmembrane protein 110 TMEM110 Homo sapiens (Human) TR21940_c3_g1_i1 Q5U465 CC125_MOUSE 8.00E-13 GO:0005737; GO:0045111 cytoplasm; intermediate filament cytoskeleton Coiled-coil domain-containing protein 125 Ccdc125 Kenae Mus musculus (Mouse) TR21940_c3_g1_i2 A2BGP7 CC125_DANRE 2.00E-10 GO:0005737 cytoplasm Coiled-coil domain-containing protein 125 ccdc125 si:ch211-244p18.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR21951_c3_g1_i1 Q9JHB4 WDR31_MOUSE 8.00E-32 IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 31 (Spermatid WD repeat-containing protein) (spWD) Wdr31 Mus musculus (Mouse) TR21953_c0_g2_i1 P60517 GBRAP_RAT 3.00E-75 GO:0000139; GO:0015629; GO:0005776; GO:0000421; GO:0006914; GO:0044297; GO:0031410; GO:0008625; GO:0005764; GO:0005874; GO:0005875; GO:0000226; GO:0048471; GO:0005886; GO:0015031; GO:0005790 Golgi membrane; actin cytoskeleton; autophagic vacuole; autophagic vacuole membrane; autophagy; cell body; cytoplasmic vesicle; extrinsic apoptotic signaling pathway via death domain receptors; lysosome; microtubule; microtubule associated complex; microtubule cytoskeleton organization; perinuclear region of cytoplasm; plasma membrane; protein transport; smooth endoplasmic reticulum IPR004241; Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) Gabarap Rattus norvegicus (Rat) TR21957_c2_g2_i2 Q8HY06 CLC4M_GORGO 2.00E-06 GO:0006897; GO:0045087; GO:0016021; GO:0005537; GO:0046872 endocytosis; innate immune response; integral to membrane; mannose binding; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (CD antigen CD299) CLEC4M CD209L1 Gorilla gorilla gorilla (Lowland gorilla) TR21959_c3_g1_i1 Q8WVQ1 CANT1_HUMAN 1.00E-91 GO:0032580; GO:0005509; GO:0005789; GO:0016021; GO:0043123; GO:0030166; GO:0004871; GO:0045134 Golgi cisterna membrane; calcium ion binding; endoplasmic reticulum membrane; integral to membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteoglycan biosynthetic process; signal transducer activity; uridine-diphosphatase activity IPR009283; Soluble calcium-activated nucleotidase 1 (SCAN-1) (EC 3.6.1.6) (Apyrase homolog) (Putative MAPK-activating protein PM09) (Putative NF-kappa-B-activating protein 107) CANT1 SHAPY Homo sapiens (Human) TR21964_c1_g1_i1 E1BLZ4 ZFY26_BOVIN 2.00E-17 GO:0006281; GO:0005813; GO:0000910; GO:0005737; GO:0046872; GO:0030496; GO:0032266 DNA repair; centrosome; cytokinesis; cytoplasm; metal ion binding; midbody; phosphatidylinositol-3-phosphate binding IPR000306; IPR017455; IPR011011; IPR013083; Zinc finger FYVE domain-containing protein 26 ZFYVE26 Bos taurus (Bovine) TR21968_c0_g1_i1 P41040 CALM_MAIZE 1.00E-37 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) CALM1 Zea mays (Maize) TR21971_c3_g1_i1 O02414 DYL1_ANTCR 7.00E-13 GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0007017; GO:0003774 cilium; cytoplasm; dynein complex; microtubule; microtubule-based process; motor activity IPR019763; IPR001372; "Dynein light chain LC6, flagellar outer arm" Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR2198_c0_g1_i1 P49641 MA2A2_HUMAN 2.00E-14 GO:0000139; GO:0030246; GO:0016799; GO:0016021; GO:0006013; GO:0004572; GO:0043687; GO:0018279; GO:0008270 "Golgi membrane; carbohydrate binding; hydrolase activity, hydrolyzing N-glycosyl compounds; integral to membrane; mannose metabolic process; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity; post-translational protein modification; protein N-linked glycosylation via asparagine; zinc ion binding" IPR011013; IPR011330; IPR013780; IPR027291; IPR011682; IPR015341; IPR000602; Protein modification; protein glycosylation. "Alpha-mannosidase 2x (EC 3.2.1.114) (Alpha-mannosidase IIx) (Man IIx) (Mannosidase alpha class 2A member 2) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)" MAN2A2 MANA2X Homo sapiens (Human) TR21981_c2_g3_i1 O94889 KLH18_HUMAN 4.00E-38 IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 18 KLHL18 KIAA0795 OK/SW-cl.74 Homo sapiens (Human) TR21992_c0_g1_i1 Q9UKR8 TSN16_HUMAN 6.00E-08 GO:0016021 integral to membrane IPR000301; IPR018499; IPR008952; Tetraspanin-16 (Tspan-16) (Tetraspanin TM4-B) (Transmembrane 4 superfamily member 16) TSPAN16 TM4SF16 Homo sapiens (Human) TR21993_c1_g1_i2 P08548 LIN1_NYCCO 2.00E-10 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR21993_c1_g1_i4 P14381 YTX2_XENLA 1.00E-12 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR21993_c2_g1_i1 P14381 YTX2_XENLA 2.00E-12 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR21994_c0_g1_i1 Q9NBX4 RTXE_DROME 6.00E-12 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR2200_c0_g1_i1 Q9UJN7 ZN391_HUMAN 5.00E-18 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 391 ZNF391 Homo sapiens (Human) TR22001_c0_g2_i1 Q9D9X6 ZSWM2_MOUSE 3.00E-12 GO:0006915; GO:1902043; GO:0000209; GO:0043621; GO:0004842; GO:0008270 apoptotic process; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; protein polyubiquitination; protein self-association; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; IPR007527; IPR000433; E3 ubiquitin-protein ligase Zswim2 (EC 6.3.2.-) (MEKK1-related protein X) (MEX) (ZZ-type zinc finger-containing protein 2) (Zinc finger SWIM domain-containing protein 2) Zswim2 Mus musculus (Mouse) TR22001_c0_g2_i2 Q9D9X6 ZSWM2_MOUSE 8.00E-13 GO:0006915; GO:1902043; GO:0000209; GO:0043621; GO:0004842; GO:0008270 apoptotic process; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; protein polyubiquitination; protein self-association; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; IPR007527; IPR000433; E3 ubiquitin-protein ligase Zswim2 (EC 6.3.2.-) (MEKK1-related protein X) (MEX) (ZZ-type zinc finger-containing protein 2) (Zinc finger SWIM domain-containing protein 2) Zswim2 Mus musculus (Mouse) TR22005_c1_g1_i1 Q8CFA7 KLF17_MOUSE 1.00E-08 GO:0007276; GO:0046872; GO:0005634; GO:0006357; GO:0003700; GO:0044212; GO:0006351 "gamete generation; metal ion binding; nucleus; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Krueppel-like factor 17 (Germ cell-specific zinc finger protein) (Zinc finger protein 393) Klf17 Gzf Zfp393 Znf393 Mus musculus (Mouse) TR22006_c0_g1_i2 Q7YRK3 COX6C_PONPY 3.00E-09 GO:0004129; GO:0016021; GO:0005743 cytochrome-c oxidase activity; integral to membrane; mitochondrial inner membrane IPR004204; Cytochrome c oxidase subunit 6C (Cytochrome c oxidase polypeptide VIc) COX6C Pongo pygmaeus (Bornean orangutan) TR22008_c3_g1_i1 Q94900 GLUCL_DROME 2.00E-33 GO:0030054; GO:0034707; GO:0008068; GO:0016021; GO:0048812; GO:0005886; GO:0045211 cell junction; chloride channel complex; extracellular-glutamate-gated chloride channel activity; integral to membrane; neuron projection morphogenesis; plasma membrane; postsynaptic membrane IPR006028; IPR006202; IPR006201; IPR006029; IPR018000; Glutamate-gated chloride channel (DrosGluCl) GluClalpha GluCl CG7535 Drosophila melanogaster (Fruit fly) TR22009_c0_g2_i1 P47805 M1I1A_DANRE 1.00E-08 GO:0005737; GO:0005874; GO:0005634 cytoplasm; microtubule; nucleus IPR009786; Mid1-interacting protein 1A (Gastrulation-specific protein G12) mid1ip1a g12 Danio rerio (Zebrafish) (Brachydanio rerio) TR22015_c1_g1_i1 H2A0M3 AMO_PINMG 8.00E-62 GO:0009308; GO:0005507; GO:0005576; GO:0008131; GO:0048038 amine metabolic process; copper ion binding; extracellular region; primary amine oxidase activity; quinone binding IPR000269; IPR015798; IPR016182; IPR015801; Putative amine oxidase [copper-containing] (EC 1.4.3.-) Pinctada margaritifera (Black-lipped pearl oyster) TR22018_c1_g1_i1 Q5IS41 NCAN_PANTR 3.00E-15 GO:0005509; GO:0030246; GO:0007155; GO:0005576; GO:0005540 calcium ion binding; carbohydrate binding; cell adhesion; extracellular region; hyaluronic acid binding IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Neurocan core protein (Chondroitin sulfate proteoglycan 3) NCAN CSPG3 Pan troglodytes (Chimpanzee) TR22019_c1_g1_i1 Q08DZ3 ELMD2_BOVIN 3.00E-50 GO:0005096; GO:0005856; GO:0006909; GO:0050688 GTPase activator activity; cytoskeleton; phagocytosis; regulation of defense response to virus IPR006816; ELMO domain-containing protein 2 ELMOD2 Bos taurus (Bovine) TR22023_c0_g1_i2 Q75N62 GIMA8_MOUSE 4.00E-06 GO:0005525; GO:0005794; GO:0005829; GO:0005783; GO:0005739; GO:0005634 GTP binding; Golgi apparatus; cytosol; endoplasmic reticulum; mitochondrion; nucleus IPR006703; IPR027417; GTPase IMAP family member 8 (mGIMAP8) (Immune-associated nucleotide-binding protein 9) (IAN-9) (Immunity-associated protein 8) Gimap8 Ian9 Imap8 Mus musculus (Mouse) TR22028_c0_g1_i1 Q5UNW9 YR718_MIMIV 1.00E-07 IPR025475; Uncharacterized protein R718 MIMI_R718 Acanthamoeba polyphaga mimivirus (APMV) TR22034_c0_g2_i1 A3CN70 LDH_STRSV 2.00E-08 GO:0004459; GO:0044262; GO:0005737; GO:0006096 L-lactate dehydrogenase activity; cellular carbohydrate metabolic process; cytoplasm; glycolysis IPR001557; IPR011304; IPR018177; IPR022383; IPR001236; IPR015955; IPR016040; Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. L-lactate dehydrogenase (L-LDH) (EC 1.1.1.27) ldh SSA_1221 Streptococcus sanguinis (strain SK36) TR22034_c0_g2_i2 Q5NVR2 MDHM_PONAB 1.00E-167 GO:0030060; GO:0044262; GO:0006475; GO:0006108; GO:0005759; GO:0006099 L-malate dehydrogenase activity; cellular carbohydrate metabolic process; internal protein amino acid acetylation; malate metabolic process; mitochondrial matrix; tricarboxylic acid cycle IPR001557; IPR022383; IPR001236; IPR015955; IPR001252; IPR010097; IPR016040; "Malate dehydrogenase, mitochondrial (EC 1.1.1.37)" MDH2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR22039_c0_g1_i1 B4NG41 MTNA_DROWI 3.00E-142 GO:0019509; GO:0046523; GO:0005737; GO:0005634 L-methionine salvage from methylthioadenosine; S-methyl-5-thioribose-1-phosphate isomerase activity; cytoplasm; nucleus IPR000649; IPR005251; IPR011559; IPR027363; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. Methylthioribose-1-phosphate isomerase (M1Pi) (MTR-1-P isomerase) (EC 5.3.1.23) (S-methyl-5-thioribose-1-phosphate isomerase) (Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein) GK22419 Drosophila willistoni (Fruit fly) TR2204_c0_g1_i1 Q80SU7 GVIN1_MOUSE 6.00E-30 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR027417; Interferon-induced very large GTPase 1 (Very large-inducible GTPase-1) (VLIG-1) Gvin1 Mus musculus (Mouse) TR22042_c5_g1_i1 Q03468 ERCC6_HUMAN 2.00E-10 GO:0005524; GO:0003677; GO:0008094; GO:0007256; GO:0007257; GO:0006284; GO:0003682; GO:0004386; GO:0008630; GO:0035264; GO:0005730; GO:0045494; GO:0032786; GO:0032403; GO:0006290; GO:0009411; GO:0010224; GO:0010165; GO:0010332; GO:0006979; GO:0000303; GO:0009636; GO:0008023; GO:0006366; GO:0006283 Q13216-1 "ATP binding; DNA binding; DNA-dependent ATPase activity; activation of JNKK activity; activation of JUN kinase activity; base-excision repair; chromatin binding; helicase activity; intrinsic apoptotic signaling pathway in response to DNA damage; multicellular organism growth; nucleolus; photoreceptor cell maintenance; positive regulation of DNA-dependent transcription, elongation; protein complex binding; pyrimidine dimer repair; response to UV; response to UV-B; response to X-ray; response to gamma radiation; response to oxidative stress; response to superoxide; response to toxic substance; transcription elongation factor complex; transcription from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair" IPR014001; IPR001650; IPR027417; IPR000330; DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) ERCC6 CSB Homo sapiens (Human) TR22043_c0_g1_i1 Q7T2D0 SGSM3_DANRE 1.00E-38 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; IPR004012; IPR001452; Small G protein signaling modulator 3 (RUN and TBC1 domain-containing protein 3) sgsm3 rutbc3 Danio rerio (Zebrafish) (Brachydanio rerio) TR22045_c0_g1_i1 P0AG05 S3AD_ECOLX 3.00E-124 GO:0005524; GO:0009012; GO:0046677 ATP binding; aminoglycoside 3''-adenylyltransferase activity; response to antibiotic IPR025184; IPR002934; IPR024172; Streptomycin 3''-adenylyltransferase (EC 2.7.7.47) aadA Escherichia coli TR22045_c1_g1_i1 P0AG05 S3AD_ECOLX 1.00E-49 GO:0005524; GO:0009012; GO:0046677 ATP binding; aminoglycoside 3''-adenylyltransferase activity; response to antibiotic IPR025184; IPR002934; IPR024172; Streptomycin 3''-adenylyltransferase (EC 2.7.7.47) aadA Escherichia coli TR22048_c0_g1_i1 O94431 YHKC_SCHPO 8.00E-22 GO:0005829; GO:0005634; GO:0030170; GO:0008483 cytosol; nucleus; pyridoxal phosphate binding; transaminase activity IPR000192; IPR015424; IPR015421; Uncharacterized aminotransferase C660.12c (EC 2.6.-.-) SPBC660.12c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR22051_c0_g1_i1 O75695 XRP2_HUMAN 8.00E-46 GO:0005524; GO:0006241; GO:0005525; GO:0006183; GO:0005096; GO:0006228; GO:0000902; GO:0005929; GO:0005737; GO:0007010; GO:0004550; GO:0005886; GO:0006457; GO:0015031; GO:0051082; GO:0007601 ATP binding; CTP biosynthetic process; GTP binding; GTP biosynthetic process; GTPase activator activity; UTP biosynthetic process; cell morphogenesis; cilium; cytoplasm; cytoskeleton organization; nucleoside diphosphate kinase activity; plasma membrane; protein folding; protein transport; unfolded protein binding; visual perception IPR013912; IPR017901; IPR016098; IPR006599; IPR001564; IPR017332; IPR012945; Protein XRP2 RP2 Homo sapiens (Human) TR22051_c0_g2_i1 Q8AVX5 XRP2_XENLA 4.00E-44 GO:0005524; GO:0006241; GO:0005525; GO:0006183; GO:0005096; GO:0006228; GO:0000902; GO:0005737; GO:0007010; GO:0004550; GO:0005886 ATP binding; CTP biosynthetic process; GTP binding; GTP biosynthetic process; GTPase activator activity; UTP biosynthetic process; cell morphogenesis; cytoplasm; cytoskeleton organization; nucleoside diphosphate kinase activity; plasma membrane IPR013912; IPR017901; IPR016098; IPR006599; IPR001564; IPR017332; IPR012945; Protein XRP2 rp2 Xenopus laevis (African clawed frog) TR22051_c0_g4_i1 Q3SZE9 TBCC_BOVIN 6.00E-07 GO:0003924; GO:0000902; GO:0005829; GO:0032391; GO:0007023 GTPase activity; cell morphogenesis; cytosol; photoreceptor connecting cilium; post-chaperonin tubulin folding pathway IPR017901; IPR016098; IPR006599; IPR027684; IPR012945; Tubulin-specific chaperone C (Tubulin-folding cofactor C) (CFC) TBCC Bos taurus (Bovine) TR22052_c0_g1_i1 Q8BYI9 TENR_MOUSE 4.00E-35 GO:0008306; GO:0009986; GO:0005737; GO:0030198; GO:0035641; GO:0060291; GO:0045121; GO:0048692; GO:0022408; GO:0050805; GO:0050885; GO:0007158; GO:0005634; GO:0072534; GO:0051968; GO:0005578; GO:0046625; GO:0050808; GO:0022029 "associative learning; cell surface; cytoplasm; extracellular matrix organization; locomotory exploration behavior; long-term synaptic potentiation; membrane raft; negative regulation of axon extension involved in regeneration; negative regulation of cell-cell adhesion; negative regulation of synaptic transmission; neuromuscular process controlling balance; neuron cell-cell adhesion; nucleus; perineuronal net; positive regulation of synaptic transmission, glutamatergic; proteinaceous extracellular matrix; sphingolipid binding; synapse organization; telencephalon cell migration" IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin-R (TN-R) (Janusin) (Neural recognition molecule J1-160/180) (Restrictin) Tnr Mus musculus (Mouse) TR22053_c0_g1_i1 D3ZQX4 APC15_RAT 5.00E-14 GO:0005680; GO:0051301; GO:0007067; GO:0090266 anaphase-promoting complex; cell division; mitosis; regulation of mitotic cell cycle spindle assembly checkpoint IPR026182; Anaphase-promoting complex subunit 15 (APC15) Anapc15 Rattus norvegicus (Rat) TR22060_c1_g2_i1 P54864 JUN_SERCA 2.00E-43 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; IPR015558; IPR005643; IPR002112; IPR008917; Transcription factor AP-1 (Proto-oncogene c-Jun) JUN Serinus canaria (Island canary) (Fringilla canaria) TR22062_c2_g1_i1 Q9HCE9 ANO8_HUMAN 5.00E-11 GO:0016021; GO:0005622; GO:0034220; GO:0005886 integral to membrane; intracellular; ion transmembrane transport; plasma membrane IPR007632; Anoctamin-8 (Transmembrane protein 16H) ANO8 KIAA1623 TMEM16H Homo sapiens (Human) TR22070_c2_g1_i1 Q99680 GPR22_HUMAN 3.00E-11 GO:0004930; GO:0005887 G-protein coupled receptor activity; integral to plasma membrane IPR000276; IPR017452; Probable G-protein coupled receptor 22 GPR22 Homo sapiens (Human) TR22075_c0_g2_i1 Q8SSS9 QKGA_DICDI 1.00E-06 GO:0005524; GO:0005525; GO:0005737; GO:0031158; GO:0008285; GO:0006997; GO:0004674; GO:0007264 ATP binding; GTP binding; cytoplasm; negative regulation of aggregate size involved in sorocarp development; negative regulation of cell proliferation; nucleus organization; protein serine/threonine kinase activity; small GTPase mediated signal transduction IPR011009; IPR001611; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR001245; Probable serine/threonine-protein kinase qkgA (EC 2.7.11.1) (Quick growth protein qkgA) (Ras of complex proteins and C-terminal of roc 2) qkgA-1 roco2-1 DDB_G0273259; qkgA-2 roco2-2 DDB_G0273635 Dictyostelium discoideum (Slime mold) TR22077_c3_g1_i2 A0PJN4 U2QL1_MOUSE 9.00E-19 GO:0005524; GO:0004842 ATP binding; ubiquitin-protein ligase activity IPR000608; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2Q-like protein 1 (EC 6.3.2.19) Ube2ql1 Mus musculus (Mouse) TR22087_c0_g1_i1 Q978J0 Y1425_THEVO 2.00E-08 IPR002110; IPR020683; Putative ankyrin repeat protein TV1425 TV1425 TVG1472127 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) TR22090_c0_g1_i1 Q3SZW3 ARV1_BOVIN 8.00E-27 GO:0016021; GO:0006665 integral to membrane; sphingolipid metabolic process IPR007290; Protein ARV1 ARV1 Bos taurus (Bovine) TR22098_c2_g1_i1 Q99835 SMO_HUMAN 2.00E-43 GO:0004930; GO:0030165; GO:0042813; GO:0017147; GO:0021984; GO:0048846; GO:0060070; GO:0010002; GO:0001708; GO:0071397; GO:0021953; GO:0021696; GO:0060830; GO:0060170; GO:0005737; GO:0060248; GO:0003140; GO:0021904; GO:0008144; GO:0031076; GO:0048557; GO:0048702; GO:0048703; GO:0060684; GO:0031017; GO:0021561; GO:0021508; GO:0048853; GO:0008406; GO:0031069; GO:0001947; GO:0001701; GO:0016021; GO:0060644; GO:0072285; GO:0007494; GO:0035264; GO:0042693; GO:0043392; GO:0043066; GO:0030857; GO:0010629; GO:0051799; GO:0000122; GO:0001755; GO:0048663; GO:0031102; GO:0043025; GO:0042475; GO:0001649; GO:0032474; GO:0061113; GO:0005886; GO:0090190; GO:0050679; GO:0010628; GO:0007228; GO:0002053; GO:0002052; GO:0042307; GO:0045880; GO:0045944; GO:0072372; GO:0034504; GO:0050821; GO:2000826; GO:2000036; GO:0048752; GO:0021938; GO:0021910; GO:0061053; GO:0007283; GO:0021794; GO:0003323; GO:0001570; GO:0007371 G-protein coupled receptor activity; PDZ domain binding; Wnt-activated receptor activity; Wnt-protein binding; adenohypophysis development; axon extension involved in axon guidance; canonical Wnt receptor signaling pathway; cardioblast differentiation; cell fate specification; cellular response to cholesterol; central nervous system neuron differentiation; cerebellar cortex morphogenesis; ciliary receptor clustering involved in smoothened signaling pathway; cilium membrane; cytoplasm; detection of cell density by contact stimulus involved in contact inhibition; determination of left/right asymmetry in lateral mesoderm; dorsal/ventral neural tube patterning; drug binding; embryonic camera-type eye development; embryonic digestive tract morphogenesis; embryonic neurocranium morphogenesis; embryonic viscerocranium morphogenesis; epithelial-mesenchymal cell signaling; exocrine pancreas development; facial nerve development; floor plate formation; forebrain morphogenesis; gonad development; hair follicle morphogenesis; heart looping; in utero embryonic development; integral to membrane; mammary gland epithelial cell differentiation; mesenchymal to epithelial transition involved in metanephric renal vesicle formation; midgut development; multicellular organism growth; muscle cell fate commitment; negative regulation of DNA binding; negative regulation of apoptotic process; negative regulation of epithelial cell differentiation; negative regulation of gene expression; negative regulation of hair follicle development; negative regulation of transcription from RNA polymerase II promoter; neural crest cell migration; neuron fate commitment; neuron projection regeneration; neuronal cell body; odontogenesis of dentin-containing tooth; osteoblast differentiation; otolith morphogenesis; pancreas morphogenesis; plasma membrane; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of epithelial cell proliferation; positive regulation of gene expression; positive regulation of hh target transcription factor activity; positive regulation of mesenchymal cell proliferation; positive regulation of neuroblast proliferation; positive regulation of protein import into nucleus; positive regulation of smoothened signaling pathway; positive regulation of transcription from RNA polymerase II promoter; primary cilium; protein localization to nucleus; protein stabilization; regulation of heart morphogenesis; regulation of stem cell maintenance; semicircular canal morphogenesis; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation; smoothened signaling pathway involved in ventral spinal cord patterning; somite development; spermatogenesis; thalamus development; type B pancreatic cell development; vasculogenesis; ventral midline determination IPR000539; IPR015526; IPR020067; IPR017981; IPR026544; Smoothened homolog (SMO) (Protein Gx) SMO SMOH Homo sapiens (Human) TR22098_c3_g1_i1 P91682 SMO_DROME 2.00E-22 GO:0001746; GO:0004930; GO:0030165; GO:0042813; GO:0017147; GO:0007193; GO:0048099; GO:0048846; GO:0007350; GO:0060070; GO:0010002; GO:0021696; GO:0060830; GO:0005929; GO:0007368; GO:0005768; GO:0007455; GO:0008406; GO:0003007; GO:0008158; GO:0005887; GO:2000134; GO:0045746; GO:0043066; GO:0048663; GO:0031102; GO:0043025; GO:0030707; GO:0090004; GO:0002052; GO:0045880; GO:0021938; GO:0035019; GO:0001570; GO:0048100 O16844 "Bolwig's organ morphogenesis; G-protein coupled receptor activity; PDZ domain binding; Wnt-activated receptor activity; Wnt-protein binding; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; anterior/posterior lineage restriction, imaginal disc; axon extension involved in axon guidance; blastoderm segmentation; canonical Wnt receptor signaling pathway; cardioblast differentiation; cerebellar cortex morphogenesis; ciliary receptor clustering involved in smoothened signaling pathway; cilium; determination of left/right symmetry; endosome; eye-antennal disc morphogenesis; gonad development; heart morphogenesis; hedgehog receptor activity; integral to plasma membrane; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of Notch signaling pathway; negative regulation of apoptotic process; neuron fate commitment; neuron projection regeneration; neuronal cell body; ovarian follicle cell development; positive regulation of establishment of protein localization to plasma membrane; positive regulation of neuroblast proliferation; positive regulation of smoothened signaling pathway; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation; somatic stem cell maintenance; vasculogenesis; wing disc anterior/posterior pattern formation" IPR000539; IPR015526; IPR020067; IPR017981; IPR026544; Protein smoothened (SMOH) (Smooth) (dSMO) smo CG11561 Drosophila melanogaster (Fruit fly) TR2211_c0_g1_i1 Q12901 ZN155_HUMAN 4.00E-12 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 155 ZNF155 Homo sapiens (Human) TR22111_c0_g1_i1 P51569 AGAL_MOUSE 7.00E-26 GO:0005794; GO:0004557; GO:0005576; GO:0016139; GO:0046477; GO:0005764; GO:0045019; GO:0051001; GO:0009311; GO:0042803; GO:0052692; GO:0005102 Golgi apparatus; alpha-galactosidase activity; extracellular region; glycoside catabolic process; glycosylceramide catabolic process; lysosome; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; oligosaccharide metabolic process; protein homodimerization activity; raffinose alpha-galactosidase activity; receptor binding IPR013785; IPR013780; IPR002241; IPR000111; IPR017853; Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Melibiase) Gla Ags Mus musculus (Mouse) TR22111_c0_g2_i1 P06280 AGAL_HUMAN 2.00E-25 GO:0005794; GO:0004557; GO:0005576; GO:0016936; GO:0016139; GO:0046477; GO:0043202; GO:0045019; GO:0051001; GO:0009311; GO:0042803; GO:0052692; GO:0005102; GO:0044281 Golgi apparatus; alpha-galactosidase activity; extracellular region; galactoside binding; glycoside catabolic process; glycosylceramide catabolic process; lysosomal lumen; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; oligosaccharide metabolic process; protein homodimerization activity; raffinose alpha-galactosidase activity; receptor binding; small molecule metabolic process IPR013785; IPR013780; IPR002241; IPR000111; IPR017853; Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Melibiase) (Agalsidase) GLA Homo sapiens (Human) TR22114_c0_g1_i1 P42700 RO60_XENLA 6.00E-18 GO:0003723; GO:0030030; GO:0005737; GO:0046872; GO:0030529 RNA binding; cell projection organization; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) trove2 Xenopus laevis (African clawed frog) TR22115_c0_g1_i1 Q8Q0U0 Y045_METMA 2.00E-12 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR22115_c1_g1_i1 Q8WXD9 CSKI1_HUMAN 8.00E-07 GO:0005737; GO:0007165 cytoplasm; signal transduction IPR002110; IPR020683; IPR027013; IPR027001; IPR001660; IPR013761; IPR021129; IPR011511; IPR001452; Caskin-1 (CASK-interacting protein 1) CASKIN1 KIAA1306 Homo sapiens (Human) TR22115_c3_g1_i1 Q13418 ILK_HUMAN 7.00E-08 GO:0005524; GO:0001658; GO:0007569; GO:0007050; GO:0034329; GO:0008283; GO:0005911; GO:0007160; GO:0043034; GO:0005829; GO:0043198; GO:0045197; GO:0043206; GO:0005925; GO:0007229; GO:0030027; GO:0032288; GO:0022011; GO:0010667; GO:0043524; GO:0006469; GO:0014912; GO:0048662; GO:0021675; GO:0048812; GO:0043025; GO:0018105; GO:0005886; GO:0030513; GO:0043406; GO:0045773; GO:0090263; GO:0030335; GO:0008284; GO:0001954; GO:0050775; GO:0045663; GO:0045669; GO:0042327; GO:0051897; GO:0045893; GO:0043234; GO:0051291; GO:0043491; GO:0004674; GO:0032956; GO:0030017; GO:0004871; GO:0034446; GO:0043195 Q14790; P55211; Q9H0C8; P48059; Q9NVD7; Q6R327; Q9BWU0; Q9UMS6 "ATP binding; branching involved in ureteric bud morphogenesis; cell aging; cell cycle arrest; cell junction assembly; cell proliferation; cell-cell junction; cell-matrix adhesion; costamere; cytosol; dendritic shaft; establishment or maintenance of epithelial cell apical/basal polarity; extracellular fibril organization; focal adhesion; integrin-mediated signaling pathway; lamellipodium; myelin assembly; myelination in peripheral nervous system; negative regulation of cardiac muscle cell apoptotic process; negative regulation of neuron apoptotic process; negative regulation of protein kinase activity; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; nerve development; neuron projection morphogenesis; neuronal cell body; peptidyl-serine phosphorylation; plasma membrane; positive regulation of BMP signaling pathway; positive regulation of MAP kinase activity; positive regulation of axon extension; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of dendrite morphogenesis; positive regulation of myoblast differentiation; positive regulation of osteoblast differentiation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of transcription, DNA-dependent; protein complex; protein heterooligomerization; protein kinase B signaling cascade; protein serine/threonine kinase activity; regulation of actin cytoskeleton organization; sarcomere; signal transducer activity; substrate adhesion-dependent cell spreading; terminal bouton" IPR002110; IPR020683; IPR016253; IPR011009; IPR000719; IPR001245; Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (ILK-1) (ILK-2) (p59ILK) ILK ILK1 ILK2 Homo sapiens (Human) TR22116_c0_g1_i1 Q1KKZ1 SKAP2_TAKRU 2.00E-07 GO:0042113; GO:0005737; GO:0005543 B cell activation; cytoplasm; phospholipid binding IPR011993; IPR001849; IPR001452; Src kinase-associated phosphoprotein 2 (Src family-associated phosphoprotein 2) skap2 scap2 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR22116_c0_g2_i1 Q86WV1 SKAP1_HUMAN 7.00E-11 GO:0042169; GO:0005070; GO:0050852; GO:0003823; GO:0005737; GO:0005634; GO:0005543; GO:0005886; GO:0045944 O15117 SH2 domain binding; SH3/SH2 adaptor activity; T cell receptor signaling pathway; antigen binding; cytoplasm; nucleus; phospholipid binding; plasma membrane; positive regulation of transcription from RNA polymerase II promoter IPR011993; IPR001849; IPR001452; Src kinase-associated phosphoprotein 1 (Src family-associated phosphoprotein 1) (Src kinase-associated phosphoprotein of 55 kDa) (SKAP-55) (pp55) SKAP1 SCAP1 SKAP55 Homo sapiens (Human) TR2212_c0_g1_i1 P86854 PLCL_MYTGA 3.00E-19 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR22131_c0_g2_i1 P14381 YTX2_XENLA 2.00E-11 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR22132_c2_g1_i1 E9PVD1 CCD62_MOUSE 5.00E-22 GO:0005737; GO:0005634; GO:0005886 cytoplasm; nucleus; plasma membrane Coiled-coil domain-containing protein 62 Ccdc62 Mus musculus (Mouse) TR22134_c0_g2_i1 Q6P026 BAF_DANRE 1.00E-08 GO:0003677; GO:0005694; GO:0005634 DNA binding; chromosome; nucleus IPR004122; Barrier-to-autointegration factor banf1 baf zgc:77767 Danio rerio (Zebrafish) (Brachydanio rerio) TR22138_c1_g1_i1 Q7SIG2 CTR1_SOLIN 2.00E-19 GO:0005615; GO:0006508; GO:0004252 extracellular space; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Chymotrypsin-1 (EC 3.4.21.1) (Chymotrypsin I) (Soli C1) Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri) TR22141_c1_g1_i1 P0C227 GLB_NERAL 4.00E-16 GO:0005576; GO:0020037; GO:0005833; GO:0005506; GO:0019825; GO:0005344 extracellular region; heme binding; hemoglobin complex; iron ion binding; oxygen binding; oxygen transporter activity IPR002336; IPR000971; IPR009050; IPR012292; Globin (Myoglobin) Nerita albicilla (Ox-palate nerite) (Theliostyla albicilla) TR22144_c0_g1_i1 P18101 RL40_DROME 3.00E-87 GO:0006464; GO:0022625; GO:0005875; GO:0005634; GO:0003735; GO:0006412; GO:0006511 cellular protein modification process; cytosolic large ribosomal subunit; microtubule associated complex; nucleus; structural constituent of ribosome; translation; ubiquitin-dependent protein catabolic process IPR001975; IPR019956; IPR019954; IPR000626; Ubiquitin-60S ribosomal protein L40 (CEP52) [Cleaved into: Ubiquitin; 60S ribosomal protein L40] RpL40 Ubi-f UBI-F52 CG2960 Drosophila melanogaster (Fruit fly) TR22148_c0_g1_i1 A9XE49 IL17L_CRAGI 2.00E-08 GO:0005576; GO:0006954 extracellular region; inflammatory response IPR010345; Interleukin 17-like protein (CgIL-17) Crassostrea gigas (Pacific oyster) (Crassostrea angulata) TR22151_c1_g1_i1 Q28024 GBG12_BOVIN 4.00E-06 GO:0007186; GO:0005834; GO:0004871 G-protein coupled receptor signaling pathway; heterotrimeric G-protein complex; signal transducer activity IPR015898; IPR001770; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Gamma-S1) GNG12 GNGT12 Bos taurus (Bovine) TR22151_c1_g1_i2 Q28024 GBG12_BOVIN 4.00E-06 GO:0007186; GO:0005834; GO:0004871 G-protein coupled receptor signaling pathway; heterotrimeric G-protein complex; signal transducer activity IPR015898; IPR001770; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Gamma-S1) GNG12 GNGT12 Bos taurus (Bovine) TR22177_c0_g1_i1 Q5XJS5 THOC6_DANRE 2.00E-89 GO:0003723; GO:0008380; GO:0006915; GO:0006397; GO:0051028; GO:0007275; GO:0005634 RNA binding; RNA splicing; apoptotic process; mRNA processing; mRNA transport; multicellular organismal development; nucleus IPR015943; IPR001680; IPR019775; IPR017986; THO complex subunit 6 homolog (WD repeat-containing protein 58) thoc6 wdr58 zgc:101618 Danio rerio (Zebrafish) (Brachydanio rerio) TR22177_c0_g1_i2 Q54N86 FBXAL_DICDI 5.00E-11 GO:0008289 lipid binding IPR001810; IPR023393; IPR002913; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein A-like protein DDB_G0285445 Dictyostelium discoideum (Slime mold) TR22180_c3_g1_i2 O01393 UNC9_CAEEL 2.00E-40 GO:0005921; GO:0055077; GO:0016021; GO:0034220; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transmembrane transport; plasma membrane IPR000990; Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans TR22183_c0_g1_i1 P24044 CALM_PLAFA 3.00E-16 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) Plasmodium falciparum TR22184_c0_g1_i1 Q0DZP5 CML17_ORYSJ 2.00E-06 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Probable calcium-binding protein CML17 (Calmodulin-like protein 17) CML17 Os02g0606600 LOC_Os02g39380 Oryza sativa subsp. japonica (Rice) TR22189_c1_g1_i1 Q9NB04 PATJ_DROME 7.00E-11 GO:0005912; GO:0034334; GO:0045179; GO:0016324; GO:0045176; GO:0016327; GO:0001736; GO:0035088; GO:0016332; GO:0016334; GO:0005875; GO:0032033; GO:0035509; GO:0005635; GO:0045494; GO:0008594; GO:0035209; GO:0005918; GO:0035003; GO:0045186 Q0E974 adherens junction; adherens junction maintenance; apical cortex; apical plasma membrane; apical protein localization; apicolateral plasma membrane; establishment of planar polarity; establishment or maintenance of apical/basal cell polarity; establishment or maintenance of polarity of embryonic epithelium; establishment or maintenance of polarity of follicular epithelium; microtubule associated complex; myosin II light chain binding; negative regulation of myosin-light-chain-phosphatase activity; nuclear envelope; photoreceptor cell maintenance; photoreceptor cell morphogenesis; pupal development; septate junction; subapical complex; zonula adherens assembly IPR004172; IPR001478; Patj homolog Patj CG12021 Drosophila melanogaster (Fruit fly) TR22189_c4_g1_i1 Q6ZWJ1 STXB4_HUMAN 2.00E-31 GO:0005509; GO:0005737; GO:0015758; GO:0008286; GO:0045111; GO:0005634; GO:0006605 calcium ion binding; cytoplasm; glucose transport; insulin receptor signaling pathway; intermediate filament cytoskeleton; nucleus; protein targeting IPR011992; IPR001478; IPR001202; Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip) STXBP4 Homo sapiens (Human) TR22193_c1_g1_i1 Q6DE40 MANEA_XENLA 5.00E-64 GO:0000139; GO:0004569; GO:0016021 "Golgi membrane; glycoprotein endo-alpha-1,2-mannosidase activity; integral to membrane" IPR026071; "Glycoprotein endo-alpha-1,2-mannosidase (EC 3.2.1.130)" manea Xenopus laevis (African clawed frog) TR22194_c0_g1_i1 Q8CA72 GAN_MOUSE 2.00E-41 GO:0031463; GO:0008219; GO:0005737; GO:0005856; GO:0007010; GO:0016567 Cul3-RING ubiquitin ligase complex; cell death; cytoplasm; cytoskeleton; cytoskeleton organization; protein ubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Protein modification; protein ubiquitination. Gigaxonin Gan Mus musculus (Mouse) TR22194_c1_g1_i1 Q6DFU2 NS1BP_XENLA 2.00E-09 GO:0005737; GO:0005856; GO:0005634 cytoplasm; cytoskeleton; nucleus IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Influenza virus NS1A-binding protein homolog (NS1-BP) (NS1-binding protein homolog) ivns1abp Xenopus laevis (African clawed frog) TR22194_c3_g1_i1 Q5F3N5 KLH14_CHICK 6.00E-10 GO:0005829; GO:0005789 cytosol; endoplasmic reticulum membrane IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 14 KLHL14 RCJMB04_11g14 Gallus gallus (Chicken) TR22195_c0_g1_i1 Q8AVG0 ABR_XENLA 1.00E-20 GO:0005096; GO:0005089; GO:0005622; GO:0035556; GO:0005543; GO:0043547; GO:0035023 GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; intracellular; intracellular signal transduction; phospholipid binding; positive regulation of GTPase activity; regulation of Rho protein signal transduction IPR000008; IPR000219; IPR001331; IPR011993; IPR001849; IPR008936; IPR000198; Active breakpoint cluster region-related protein abr Xenopus laevis (African clawed frog) TR22195_c1_g1_i1 Q9V9S7 SYDE_DROME 3.00E-55 GO:0045467; GO:0005100; GO:0032862; GO:0048846; GO:0048789; GO:0005622; GO:0048790; GO:0048786; GO:0007165 R7 cell development; Rho GTPase activator activity; activation of Rho GTPase activity; axon extension involved in axon guidance; cytoskeletal matrix organization at active zone; intracellular; maintenance of presynaptic active zone structure; presynaptic active zone; signal transduction IPR000008; IPR001478; IPR008936; IPR000198; Rho GTPase-activating protein 100F (RhoGAP-100F) (Synapse defective protein 1 homolog) (Protein syd-1 homolog) RhoGAP100F CG1976 Drosophila melanogaster (Fruit fly) TR22195_c2_g1_i1 Q9JK83 PAR6B_MOUSE 2.00E-10 GO:0045177; GO:0005938; GO:0007049; GO:0051301; GO:0005634; GO:0005886; GO:0006461; GO:0005923 P60953; Q8TEW0 apical part of cell; cell cortex; cell cycle; cell division; nucleus; plasma membrane; protein complex assembly; tight junction IPR000270; IPR001478; Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B) Pard6b Par6b Mus musculus (Mouse) TR22201_c1_g1_i1 O16076 HSP83_DROPE 2.00E-38 GO:0005524; GO:0005737; GO:0006457; GO:0006950 ATP binding; cytoplasm; protein folding; response to stress IPR003594; IPR019805; IPR001404; IPR020575; Heat shock protein 83 (HSP 82) (Fragment) Hsp83 Hsp82 Drosophila persimilis (Fruit fly) TR22201_c2_g1_i1 P30946 HS90A_RABIT 2.00E-92 GO:0005524; GO:0016887; GO:0051131; GO:0042470; GO:0030235; GO:0045429; GO:0006457; GO:0045040; GO:0006950 ATP binding; ATPase activity; chaperone-mediated protein complex assembly; melanosome; nitric-oxide synthase regulator activity; positive regulation of nitric oxide biosynthetic process; protein folding; protein import into mitochondrial outer membrane; response to stress IPR003594; IPR019805; IPR001404; IPR020575; IPR020568; Heat shock protein HSP 90-alpha HSP90AA1 HSPCA Oryctolagus cuniculus (Rabbit) TR22205_c0_g1_i1 Q7TPV2 DZIP3_MOUSE 2.00E-09 GO:0003723; GO:0005737; GO:0016874; GO:0019902; GO:0016567; GO:0008270 RNA binding; cytoplasm; ligase activity; phosphatase binding; protein ubiquitination; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog) Dzip3 Kiaa0675 Mus musculus (Mouse) TR22206_c2_g1_i1 A7Y2X0 SC6A5_XENLA 3.00E-56 GO:0016021; GO:0005328 integral to membrane; neurotransmitter:sodium symporter activity IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (xGlyT2) (Solute carrier family 6 member 5) slc6a5 glyt2 Xenopus laevis (African clawed frog) TR22207_c0_g1_i1 Q09024 IMPL2_DROME 7.00E-16 GO:0007155; GO:0008340; GO:0005615; GO:0046627 cell adhesion; determination of adult lifespan; extracellular space; negative regulation of insulin receptor signaling pathway IPR007110; IPR013783; IPR013098; IPR003598; Neural/ectodermal development factor IMP-L2 ImpL2 CG15009 Drosophila melanogaster (Fruit fly) TR22211_c0_g1_i1 P54278 PMS2_HUMAN 8.00E-34 GO:0005524; GO:0016887; GO:0032389; GO:0004519; GO:0006298; GO:0090305; GO:0007131; GO:0042493; GO:0032138; GO:0016446; GO:0016447 P40692 ATP binding; ATPase activity; MutLalpha complex; endonuclease activity; mismatch repair; nucleic acid phosphodiester bond hydrolysis; reciprocal meiotic recombination; response to drug; single base insertion or deletion binding; somatic hypermutation of immunoglobulin genes; somatic recombination of immunoglobulin gene segments IPR013507; IPR014762; IPR002099; IPR003594; IPR014790; IPR020568; IPR014721; Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) PMS2 PMSL2 Homo sapiens (Human) TR22216_c3_g1_i1 O95780 ZN682_HUMAN 2.00E-33 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 682 ZNF682 Homo sapiens (Human) TR22216_c4_g2_i1 Q8WUU4 ZN296_HUMAN 2.00E-08 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0007283; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; spermatogenesis; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 296 (ZFP296) (Zinc finger protein 342) ZNF296 ZNF342 Homo sapiens (Human) TR22216_c5_g1_i1 Q62445 SP4_MOUSE 8.00E-16 GO:0003677; GO:0046872; GO:0005634; GO:0008016; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of heart contraction; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Transcription factor Sp4 Sp4 Mus musculus (Mouse) TR22216_c5_g1_i2 B0X0K1 KEN2_CULQU 5.00E-06 GO:0003677; GO:0045497; GO:0030540; GO:0045496; GO:0030539; GO:0046872; GO:0046426; GO:0005634; GO:0003700; GO:0006351 "DNA binding; female analia development; female genitalia development; male analia development; male genitalia development; metal ion binding; negative regulation of JAK-STAT cascade; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Transcription factor Ken 2 ken2 CPIJ012629 Culex quinquefasciatus (Southern house mosquito) (Culex pungens) TR22216_c5_g1_i3 O70494 SP3_MOUSE 1.00E-17 GO:0030183; GO:0016605; GO:0001078; GO:0000979; GO:0030217; GO:0003682; GO:0000987; GO:0060216; GO:0003690; GO:0048596; GO:0001892; GO:0060136; GO:0048706; GO:0043353; GO:0030851; GO:0001889; GO:0030324; GO:0030219; GO:0046872; GO:0030224; GO:0001779; GO:0001503; GO:0045893; GO:0017053; GO:0001829 "B cell differentiation; PML body; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II core promoter sequence-specific DNA binding; T cell differentiation; chromatin binding; core promoter proximal region sequence-specific DNA binding; definitive hemopoiesis; double-stranded DNA binding; embryonic camera-type eye morphogenesis; embryonic placenta development; embryonic process involved in female pregnancy; embryonic skeletal system development; enucleate erythrocyte differentiation; granulocyte differentiation; liver development; lung development; megakaryocyte differentiation; metal ion binding; monocyte differentiation; natural killer cell differentiation; ossification; positive regulation of transcription, DNA-dependent; transcriptional repressor complex; trophectodermal cell differentiation" IPR007087; IPR015880; IPR013087; Transcription factor Sp3 Sp3 Mus musculus (Mouse) TR22218_c1_g1_i1 O42563 CP3AR_ONCMY 2.00E-10 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR008072; IPR002402; Cytochrome P450 3A27 (EC 1.14.14.1) (CYPIIIA27) cyp3a27 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR22224_c1_g1_i1 P51522 ZNF83_HUMAN 6.00E-42 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 83 (Zinc finger protein 816B) (Zinc finger protein HPF1) ZNF83 ZNF816B Homo sapiens (Human) TR22224_c1_g1_i2 Q5R8X1 ZN665_PONAB 1.00E-41 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 665 ZNF665 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR22225_c0_g1_i1 P48305 NDUB4_BOVIN 1.00E-07 GO:0008137; GO:0016021; GO:0005743; GO:0070469; GO:0006979 NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial inner membrane; respiratory chain; response to oxidative stress IPR009866; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (Complex I-B15) (CI-B15) (NADH-ubiquinone oxidoreductase B15 subunit) NDUFB4 Bos taurus (Bovine) TR22226_c2_g1_i1 Q9VI93 RN_DROME 1.00E-46 GO:0003705; GO:0048749; GO:0007480; GO:0046872; GO:0000122; GO:0003676; GO:0005634 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; compound eye development; imaginal disc-derived leg morphogenesis; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleic acid binding; nucleus IPR007087; IPR015880; IPR013087; Zinc finger protein rotund (Zinc finger protein roughened eye) rn roe CG32466 Drosophila melanogaster (Fruit fly) TR22228_c2_g1_i1 Q58588 Y1187_METJA 2.00E-06 GO:0016787 hydrolase activity IPR005502; Uncharacterized protein MJ1187 (EC 3.2.2.-) MJ1187 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR22230_c2_g2_i1 Q9NQP4 PFD4_HUMAN 3.00E-41 GO:0051084; GO:0051087; GO:0005829; GO:0005739; GO:0005634; GO:0016272 'de novo' posttranslational protein folding; chaperone binding; cytosol; mitochondrion; nucleus; prefoldin complex IPR002777; IPR016661; IPR009053; Prefoldin subunit 4 (Protein C-1) PFDN4 PFD4 Homo sapiens (Human) TR22233_c0_g1_i1 Q96MM6 HS12B_HUMAN 5.00E-12 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR22235_c1_g2_i1 Q9P2D6 F135A_HUMAN 7.00E-15 IPR022122; IPR007751; Protein FAM135A FAM135A KIAA1411 Homo sapiens (Human) TR22235_c1_g3_i1 Q9DAI6 F135B_MOUSE 5.00E-17 IPR022122; IPR007751; Protein FAM135B Fam135b Mus musculus (Mouse) TR22237_c1_g1_i1 A4FUP9 GL1D1_MOUSE 1.00E-07 GO:0009058; GO:0005576; GO:0016757 "biosynthetic process; extracellular region; transferase activity, transferring glycosyl groups" IPR001296; Glycosyltransferase 1 domain-containing protein 1 (EC 2.4.-.-) Glt1d1 Mus musculus (Mouse) TR22239_c0_g1_i1 Q8BIK4 DOCK9_MOUSE 2.00E-20 GO:0005089; GO:0012505; GO:0016020; GO:0005543; GO:0007264 Rho guanyl-nucleotide exchange factor activity; endomembrane system; membrane; phospholipid binding; small GTPase mediated signal transduction IPR016024; IPR027007; IPR027357; IPR026791; IPR010703; IPR021816; IPR026796; IPR011993; IPR001849; Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) Dock9 D14Wsu89e Kiaa1058 Mus musculus (Mouse) TR22239_c0_g2_i1 Q8BZN6 DOC10_MOUSE 1.00E-24 GO:0005089; GO:0005543; GO:0007264 Rho guanyl-nucleotide exchange factor activity; phospholipid binding; small GTPase mediated signal transduction IPR016024; IPR027007; IPR027357; IPR026791; IPR010703; IPR021816; IPR026796; IPR011993; IPR001849; Dedicator of cytokinesis protein 10 (Zizimin-3) Dock10 Kiaa0694 Ziz3 Mus musculus (Mouse) TR22239_c1_g1_i1 Q5JSL3 DOC11_HUMAN 1.00E-26 GO:0005089; GO:0007596; GO:0005829; GO:0005543; GO:0007264 Rho guanyl-nucleotide exchange factor activity; blood coagulation; cytosol; phospholipid binding; small GTPase mediated signal transduction IPR016024; IPR027007; IPR027357; IPR026791; IPR010703; IPR021816; IPR026796; IPR011993; IPR001849; Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) DOCK11 ZIZ2 Homo sapiens (Human) TR2224_c0_g1_i1 Q5ZJQ3 LIN52_CHICK 6.00E-46 GO:0070176; GO:0007049; GO:0006351 "DRM complex; cell cycle; transcription, DNA-dependent" IPR018737; Protein lin-52 homolog LIN52 RCJMB04_16g11 Gallus gallus (Chicken) TR22245_c0_g1_i3 Q8TCT0 CERK1_HUMAN 9.00E-34 GO:0005524; GO:0003951; GO:0001729; GO:0006672; GO:0005737; GO:0004143; GO:0006687; GO:0016021; GO:0000287; GO:0005739; GO:0005634; GO:0005543; GO:0005886; GO:0007205; GO:0044281 ATP binding; NAD+ kinase activity; ceramide kinase activity; ceramide metabolic process; cytoplasm; diacylglycerol kinase activity; glycosphingolipid metabolic process; integral to membrane; magnesium ion binding; mitochondrion; nucleus; phospholipid binding; plasma membrane; protein kinase C-activating G-protein coupled receptor signaling pathway; small molecule metabolic process IPR016064; IPR001206; IPR001849; Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) TR22246_c5_g1_i1 Q8C5L6 INP5K_MOUSE 5.00E-07 GO:0071320; GO:0071364; GO:0032869; GO:0071356; GO:0005829; GO:0005783; GO:0042593; GO:0001701; GO:0016312; GO:0046855; GO:0046030; GO:0052659; GO:0052658; GO:0004445; GO:0043922; GO:0043407; GO:0051926; GO:0035305; GO:0010829; GO:2000466; GO:0045719; GO:0046627; GO:0033137; GO:0010801; GO:0051898; GO:0090315; GO:0045869; GO:0051497; GO:0045892; GO:0043005; GO:0005634; GO:0048471; GO:0046856; GO:0034485; GO:2001153; GO:0045893; GO:0035810; GO:0072661; GO:0097178; GO:0032587; GO:0005802; GO:0005000 "cellular response to cAMP; cellular response to epidermal growth factor stimulus; cellular response to insulin stimulus; cellular response to tumor necrosis factor; cytosol; endoplasmic reticulum; glucose homeostasis; in utero embryonic development; inositol bisphosphate phosphatase activity; inositol phosphate dephosphorylation; inositol trisphosphate phosphatase activity; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; inositol-1,4,5-trisphosphate 5-phosphatase activity; inositol-polyphosphate 5-phosphatase activity; negative regulation by host of viral transcription; negative regulation of MAP kinase activity; negative regulation of calcium ion transport; negative regulation of dephosphorylation; negative regulation of glucose transport; negative regulation of glycogen (starch) synthase activity; negative regulation of glycogen biosynthetic process; negative regulation of insulin receptor signaling pathway; negative regulation of peptidyl-serine phosphorylation; negative regulation of peptidyl-threonine phosphorylation; negative regulation of protein kinase B signaling cascade; negative regulation of protein targeting to membrane; negative regulation of retroviral genome replication; negative regulation of stress fiber assembly; negative regulation of transcription, DNA-dependent; neuron projection; nucleus; perinuclear region of cytoplasm; phosphatidylinositol dephosphorylation; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; positive regulation of renal water transport; positive regulation of transcription, DNA-dependent; positive regulation of urine volume; protein targeting to plasma membrane; ruffle assembly; ruffle membrane; trans-Golgi network; vasopressin receptor activity" IPR005135; IPR000300; Inositol polyphosphate 5-phosphatase K (EC 3.1.3.56) (Skeletal muscle and kidney-enriched inositol phosphatase) Inpp5k Pps Skip Mus musculus (Mouse) TR22249_c0_g2_i1 Q96HH4 TM169_HUMAN 2.00E-32 GO:0016021 integral to membrane Transmembrane protein 169 TMEM169 Homo sapiens (Human) TR22251_c3_g1_i1 A0ZSK4 STXB_SYNVE 2.00E-21 GO:0019835; GO:0005576; GO:0044179 cytolysis; extracellular region; hemolysis in other organism IPR001870; IPR003879; IPR008985; IPR006574; IPR018355; IPR003877; Neoverrucotoxin subunit beta (NeoVTX subunit beta) Synanceia verrucosa (Reef stonefish) TR22254_c0_g1_i1 Q0Z8U2 RS3_PIG 1.00E-151 GO:0003723; GO:0030529; GO:0015935; GO:0003735; GO:0006412 RNA binding; ribonucleoprotein complex; small ribosomal subunit; structural constituent of ribosome; translation IPR004087; IPR015946; IPR004044; IPR009019; IPR001351; IPR018280; IPR005703; 40S ribosomal protein S3 RPS3 Sus scrofa (Pig) TR22258_c1_g1_i1 Q7Z407 CSMD3_HUMAN 2.00E-09 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 3 (CUB and sushi multiple domains protein 3) CSMD3 KIAA1894 Homo sapiens (Human) TR22258_c4_g1_i1 Q4LDE5 SVEP1_HUMAN 8.00E-09 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) TR22261_c0_g1_i1 Q2UY09 COSA1_HUMAN 2.00E-06 GO:0005604; GO:0007155; GO:0005581; GO:0005788; GO:0030198; GO:0005576; GO:0004867 basement membrane; cell adhesion; collagen; endoplasmic reticulum lumen; extracellular matrix organization; extracellular region; serine-type endopeptidase inhibitor activity IPR008160; IPR002223; IPR020901; IPR002035; Collagen alpha-1(XXVIII) chain COL28A1 COL28 Homo sapiens (Human) TR22261_c0_g1_i2 Q29428 TKDP1_SHEEP 1.00E-10 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Trophoblast Kunitz domain protein 1 (TKDP-1) TKDP1 Ovis aries (Sheep) TR22264_c0_g1_i1 Q829L6 ECTD_STRAW 2.00E-07 GO:0016725 "oxidoreductase activity, acting on CH or CH2 groups" IPR012774; IPR008775; Ectoine hydroxylase (EC 1.17.-.-) ectD SAV_6395 Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680) TR22264_c0_g1_i2 Q5YW75 ECTD_NOCFA 5.00E-10 GO:0016725 "oxidoreductase activity, acting on CH or CH2 groups" IPR012774; IPR008775; Ectoine hydroxylase (EC 1.17.-.-) ectD NFA_27190 Nocardia farcinica (strain IFM 10152) TR22265_c0_g1_i1 Q9J5I9 V012_FOWPN 5.00E-06 IPR002110; IPR020683; IPR018272; Putative ankyrin repeat protein FPV012 FPV012 Fowlpox virus (strain NVSL) (FPV) TR22268_c0_g1_i1 P86854 PLCL_MYTGA 7.00E-75 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR22268_c0_g2_i1 P16112 PGCA_HUMAN 4.00E-23 GO:0005796; GO:0030246; GO:0005975; GO:0007155; GO:0030198; GO:0005201; GO:0005576; GO:0005540; GO:0018146; GO:0042340; GO:0043202; GO:0046872; GO:0005578; GO:0006508; GO:0001501 Golgi lumen; carbohydrate binding; carbohydrate metabolic process; cell adhesion; extracellular matrix organization; extracellular matrix structural constituent; extracellular region; hyaluronic acid binding; keratan sulfate biosynthetic process; keratan sulfate catabolic process; lysosomal lumen; metal ion binding; proteinaceous extracellular matrix; proteolysis; skeletal system development IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR007110; IPR013783; IPR003006; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2] ACAN AGC1 CSPG1 MSK16 Homo sapiens (Human) TR22270_c1_g1_i2 O94913 PCF11_HUMAN 1.00E-17 GO:0031124; GO:0006379; GO:0005849; GO:0000398; GO:0006369 "mRNA 3'-end processing; mRNA cleavage; mRNA cleavage factor complex; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription" IPR006569; IPR008942; IPR006903; Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) PCF11 KIAA0824 Homo sapiens (Human) TR22274_c0_g1_i1 P07247 KRUP_DROME 3.00E-18 GO:0061332; GO:0003705; GO:0007411; GO:0006342; GO:0048749; GO:0007402; GO:0046872; GO:0007517; GO:0000122; GO:0007400; GO:0005634; GO:0040034; GO:0035206; GO:0043565; GO:0035290; GO:0007419; GO:0035220; GO:0007354 "Malpighian tubule bud morphogenesis; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; axon guidance; chromatin silencing; compound eye development; ganglion mother cell fate determination; metal ion binding; muscle organ development; negative regulation of transcription from RNA polymerase II promoter; neuroblast fate determination; nucleus; regulation of development, heterochronic; regulation of hemocyte proliferation; sequence-specific DNA binding; trunk segmentation; ventral cord development; wing disc development; zygotic determination of anterior/posterior axis, embryo" IPR007087; IPR015880; IPR013087; Protein krueppel Kr CG3340 Drosophila melanogaster (Fruit fly) TR22274_c0_g2_i1 O60315 ZEB2_HUMAN 5.00E-11 GO:0046332; GO:0021846; GO:0005737; GO:0021766; GO:0046872; GO:0007399; GO:0001755; GO:0001843; GO:0005730; GO:0019208; GO:0043507; GO:0030177; GO:0043565; GO:0003700; GO:0001756; GO:0006351 "SMAD binding; cell proliferation in forebrain; cytoplasm; hippocampus development; metal ion binding; nervous system development; neural crest cell migration; neural tube closure; nucleolus; phosphatase regulator activity; positive regulation of JUN kinase activity; positive regulation of Wnt receptor signaling pathway; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; somitogenesis; transcription, DNA-dependent" IPR008598; IPR001356; IPR009057; IPR007087; IPR015880; IPR013087; Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) ZEB2 KIAA0569 SIP1 ZFHX1B ZFX1B HRIHFB2411 Homo sapiens (Human) TR22276_c0_g1_i3 Q96DM1 PGBD4_HUMAN 1.00E-12 PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) TR22277_c4_g2_i1 Q5U430 UBR3_MOUSE 7.00E-64 GO:0001701; GO:0016021; GO:0042048; GO:0007608; GO:0001967; GO:0006511; GO:0004842; GO:0008270 in utero embryonic development; integral to membrane; olfactory behavior; sensory perception of smell; suckling behavior; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR003126; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UBR3 (EC 6.3.2.-) (N-recognin-3) (Ubiquitin-protein ligase E3-alpha-3) (Ubiquitin-protein ligase E3-alpha-III) (Zinc finger protein 650) Ubr3 Kiaa2024 Zfp650 Znf650 Mus musculus (Mouse) TR22281_c0_g1_i1 Q96UF2 G3P2_MUCCL 0 GO:0051287; GO:0050661; GO:0005737; GO:0004365; GO:0006096 NAD binding; NADP binding; cytoplasm; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; glycolysis IPR020831; IPR020830; IPR020829; IPR020828; IPR006424; IPR016040; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. Glyceraldehyde-3-phosphate dehydrogenase 2 (GAPDH 2) (EC 1.2.1.12) GPD2 Mucor circinelloides f. lusitanicus (Mucor racemosus var. lusitanicus) TR22281_c0_g1_i2 Q96UF2 G3P2_MUCCL 0 GO:0051287; GO:0050661; GO:0005737; GO:0004365; GO:0006096 NAD binding; NADP binding; cytoplasm; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; glycolysis IPR020831; IPR020830; IPR020829; IPR020828; IPR006424; IPR016040; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. Glyceraldehyde-3-phosphate dehydrogenase 2 (GAPDH 2) (EC 1.2.1.12) GPD2 Mucor circinelloides f. lusitanicus (Mucor racemosus var. lusitanicus) TR22282_c0_g1_i1 Q6DIZ0 3HAO_XENTR 4.00E-94 GO:0000334; GO:0009435; GO:0005737; GO:0005506 "3-hydroxyanthranilate 3,4-dioxygenase activity; NAD biosynthetic process; cytoplasm; iron ion binding" IPR010329; IPR016700; IPR014710; IPR011051; Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. "3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) (3-hydroxyanthranilate oxygenase) (3-HAO) (3-hydroxyanthranilic acid dioxygenase) (HAD)" haao Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR22283_c0_g1_i1 Q96JI7 SPTCS_HUMAN 3.00E-12 GO:0008219; GO:0031410; GO:0005829; GO:0016021; GO:0005765; GO:0005730; GO:0005886 cell death; cytoplasmic vesicle; cytosol; integral to membrane; lysosomal membrane; nucleolus; plasma membrane IPR028103; IPR028107; Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) SPG11 KIAA1840 Homo sapiens (Human) TR22286_c0_g2_i1 Q6PDJ1 CAHD1_MOUSE 8.00E-58 GO:0006816; GO:0016021 calcium ion transport; integral to membrane IPR004010; IPR013608; IPR002035; VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) TR22286_c1_g1_i1 Q6UXX5 ITIH6_HUMAN 5.00E-11 GO:0005576; GO:0030212; GO:0004867 extracellular region; hyaluronan metabolic process; serine-type endopeptidase inhibitor activity IPR010600; IPR013694; IPR002035; Inter-alpha-trypsin inhibitor heavy chain H6 (Inter-alpha-trypsin inhibitor heavy chain H5-like protein) (Inter-alpha inhibitor H5-like protein) ITIH6 ITIH5L UNQ6369/PRO21074 Homo sapiens (Human) TR22289_c0_g1_i1 Q5QP82 DCA10_HUMAN 2.00E-45 GO:0080008; GO:0016567 Cul4-RING ubiquitin ligase complex; protein ubiquitination IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32) DCAF10 WDR32 Homo sapiens (Human) TR22291_c1_g1_i1 Q9EST3 4ET_MOUSE 3.00E-23 GO:0016605; GO:0005829; GO:0016607; GO:0005634; GO:0015031 PML body; cytosol; nuclear speck; nucleus; protein transport IPR018862; Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) Eif4enif1 Clast4 Mus musculus (Mouse) TR22292_c0_g1_i1 Q9U3S9 NAS6_CAEEL 2.00E-26 GO:0005576; GO:0004222; GO:0043050; GO:0060465; GO:0006508; GO:0008270 extracellular region; metalloendopeptidase activity; pharyngeal pumping; pharynx development; proteolysis; zinc ion binding IPR024079; IPR001506; IPR006026; IPR003582; Zinc metalloproteinase nas-6 (EC 3.4.24.21) (Nematode astacin 6) nas-6 4R79.1 Caenorhabditis elegans TR22292_c1_g1_i1 P91137 NAS9_CAEEL 9.00E-07 GO:0005576; GO:0004222; GO:0006508; GO:0008270 extracellular region; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR001506; IPR017368; IPR006026; IPR003582; Zinc metalloproteinase nas-9 (EC 3.4.24.21) (Nematode astacin 9) nas-9 C37H5.9 Caenorhabditis elegans TR22292_c2_g2_i1 Q8CG85 MAMC2_MOUSE 6.00E-18 GO:0005783; GO:0005539; GO:0005614; GO:0016020; GO:0019800 endoplasmic reticulum; glycosaminoglycan binding; interstitial matrix; membrane; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IPR008985; IPR000998; MAM domain-containing protein 2 (MAM domain-containing proteoglycan) (Mamcan) Mamdc2 Mus musculus (Mouse) TR22298_c1_g1_i1 Q54KF6 Y7365_DICDI 1.00E-06 IPR019316; Protein DDB_G0287365 DDB_G0287365 Dictyostelium discoideum (Slime mold) TR223_c0_g1_i1 O97490 TRFM_RABIT 2.00E-09 GO:0031225; GO:0006879; GO:0005576; GO:0008199; GO:0006826; GO:0005886 anchored to membrane; cellular iron ion homeostasis; extracellular region; ferric iron binding; iron ion transport; plasma membrane IPR016357; IPR001156; IPR018195; Melanotransferrin (Membrane-bound transferrin-like protein p97) (CD antigen CD228) Mfi2 Oryctolagus cuniculus (Rabbit) TR22303_c0_g1_i1 Q7XPJ0 KCBP_ORYSJ 1.00E-26 GO:0005524; GO:0005871; GO:0003777; GO:0007018; GO:0016491 ATP binding; kinesin complex; microtubule motor activity; microtubule-based movement; oxidoreductase activity IPR019749; IPR014352; IPR019748; IPR000299; IPR018979; IPR027640; IPR019821; IPR001752; IPR000857; IPR027417; IPR011254; Kinesin-like calmodulin-binding protein homolog Os04g0666900 LOC_Os04g57140 OSJNBa0087O24.20 Oryza sativa subsp. japonica (Rice) TR2232_c0_g1_i1 P59240 NPHP4_MOUSE 9.00E-07 GO:0005911; GO:0005813; GO:0005929; GO:0005737; GO:0005932; GO:0060041; GO:0005923 Q9QY53; Q8CG73 cell-cell junction; centrosome; cilium; cytoplasm; microtubule basal body; retina development in camera-type eye; tight junction Nephrocystin-4 (Nephroretinin) Nphp4 Mus musculus (Mouse) TR22321_c0_g1_i1 Q8C0R9 LRRD1_MOUSE 3.00E-33 IPR001611; IPR025875; IPR003591; Leucine-rich repeat and death domain-containing protein 1 Lrrd1 Mus musculus (Mouse) TR22322_c0_g1_i1 A2AV25 FBCD1_MOUSE 3.00E-16 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 Fibcd1 Mus musculus (Mouse) TR22324_c0_g1_i1 Q9LHK4 AB8B_ARATH 5.00E-19 GO:0005524; GO:0006200; GO:0042626; GO:0016021 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Putative ABC transporter B family member 8 (ABC transporter ABCB.8) (AtABCB8) (P-glycoprotein 8) (Putative multidrug resistance protein 22) ABCB8 MDR22 PGP8 At3g30875 MJI6.16 Arabidopsis thaliana (Mouse-ear cress) TR22324_c1_g1_i1 P08183 MDR1_HUMAN 2.00E-70 GO:0005524; GO:0042626; GO:0000086; GO:0000139; GO:0016324; GO:0009986; GO:0006855; GO:0016021; GO:0046581; GO:0072089; GO:0008559 Q86VI4; Q99496 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; G2/M transition of mitotic cell cycle; Golgi membrane; apical plasma membrane; cell surface; drug transmembrane transport; integral to membrane; intercellular canaliculus; stem cell proliferation; xenobiotic-transporting ATPase activity" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD antigen CD243) ABCB1 MDR1 PGY1 Homo sapiens (Human) TR22332_c0_g1_i1 Q06AT3 UCHL5_PIG 1.00E-84 GO:0006310; GO:0006281; GO:0005829; GO:0005634; GO:0008242; GO:0000502; GO:0016579; GO:0006355; GO:0006351; GO:0004221; GO:0006511; GO:0004843 "DNA recombination; DNA repair; cytosol; nucleus; omega peptidase activity; proteasome complex; protein deubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity" IPR001578; IPR017390; Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin thioesterase L5) UCHL5 Sus scrofa (Pig) TR22333_c1_g1_i1 Q3EBC8 DCL2_ARATH 5.00E-14 GO:0005524; GO:0008026; GO:0003723; GO:0005737; GO:0051607; GO:0010216; GO:0046872; GO:0090305; GO:0005634; GO:0010267; GO:0004525 O04492 ATP binding; ATP-dependent helicase activity; RNA binding; cytoplasm; defense response to virus; maintenance of DNA methylation; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleus; production of ta-siRNAs involved in RNA interference; ribonuclease III activity IPR005034; IPR011545; IPR014720; IPR014001; IPR001650; IPR027417; IPR003100; IPR000999; Endoribonuclease Dicer homolog 2 (EC 3.1.26.-) (Dicer-like protein 2) (AtDCL2) At3g03300 T17B22.1 Arabidopsis thaliana (Mouse-ear cress) TR22333_c1_g2_i1 Q09884 DCR1_SCHPO 2.00E-18 GO:0005524; GO:0016442; GO:0007049; GO:0034613; GO:0031048; GO:0007059; GO:0033562; GO:0005829; GO:0003690; GO:0003725; GO:0035389; GO:1990188; GO:0004386; GO:0031618; GO:0005719; GO:0034399; GO:0005643; GO:0030422; GO:0090052; GO:0051570; GO:0004525; GO:0004540; GO:0008270 ATP binding; RISC complex; cell cycle; cellular protein localization; chromatin silencing by small RNA; chromosome segregation; co-transcriptional gene silencing by RNA interference machinery; cytosol; double-stranded DNA binding; double-stranded RNA binding; establishment of chromatin silencing at silent mating-type cassette; euchromatin binding; helicase activity; nuclear centromeric heterochromatin; nuclear euchromatin; nuclear periphery; nuclear pore; production of siRNA involved in RNA interference; regulation of chromatin silencing at centromere; regulation of histone H3-K9 methylation; ribonuclease III activity; ribonuclease activity; zinc ion binding IPR005034; IPR006935; IPR014001; IPR001650; IPR027417; IPR000999; Protein Dicer (Cell cycle control protein dcr1) (RNA interference pathway protein dcr1) [Includes: Endoribonuclease dcr1 (EC 3.1.26.-); ATP-dependent helicase dcr1 (EC 3.6.4.-)] dcr1 SPCC188.13c SPCC584.10c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR22341_c0_g1_i1 P54822 PUR8_MOUSE 1.00E-13 GO:0044208; GO:0006189; GO:0070626; GO:0006167; GO:0004018; GO:0005739; GO:0051262 "'de novo' AMP biosynthetic process; 'de novo' IMP biosynthetic process; (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity; AMP biosynthetic process; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; mitochondrion; protein tetramerization" IPR019468; IPR024083; IPR020557; IPR000362; IPR022761; IPR008948; IPR004769; Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2. Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2. Adenylosuccinate lyase (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) Adsl Adl Mus musculus (Mouse) TR22344_c0_g2_i1 Q8BGB5 LIMD2_MOUSE 3.00E-18 GO:0008270 zinc ion binding IPR001781; LIM domain-containing protein 2 Limd2 Mus musculus (Mouse) TR22345_c0_g1_i1 P22792 CPN2_HUMAN 2.00E-07 GO:0030234; GO:0005576; GO:0050821 enzyme regulator activity; extracellular region; protein stabilization IPR000483; IPR001611; IPR025875; IPR003591; IPR000372; Carboxypeptidase N subunit 2 (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N large subunit) (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N regulatory subunit) CPN2 ACBP Homo sapiens (Human) TR22345_c2_g1_i1 Q15399 TLR1_HUMAN 5.00E-19 GO:0002755; GO:0042088; GO:0035354; GO:0071727; GO:0042496; GO:0042495; GO:0006955; GO:0006954; GO:0045087; GO:0005887; GO:0042116; GO:0030670; GO:0045410; GO:0042535; GO:0046982; GO:0050707; GO:0034150; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; T-helper 1 type immune response; Toll-like receptor 1-Toll-like receptor 2 protein complex; cellular response to triacyl bacterial lipopeptide; detection of diacyl bacterial lipopeptide; detection of triacyl bacterial lipopeptide; immune response; inflammatory response; innate immune response; integral to plasma membrane; macrophage activation; phagocytic vesicle membrane; positive regulation of interleukin-6 biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; protein heterodimerization activity; regulation of cytokine secretion; toll-like receptor 6 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR000157; IPR027187; IPR017241; Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) TLR1 KIAA0012 Homo sapiens (Human) TR22345_c3_g1_i1 Q9NYK1 TLR7_HUMAN 8.00E-15 GO:0000139; GO:0007252; GO:0002755; GO:0071260; GO:0051607; GO:0003725; GO:0008144; GO:0032009; GO:0036020; GO:0005789; GO:0006954; GO:0045087; GO:0016021; GO:0002282; GO:0052033; GO:0005886; GO:0042346; GO:0032722; GO:0050729; GO:0045356; GO:0045359; GO:0045078; GO:0032755; GO:0045416; GO:0032757; GO:0042221; GO:0035197; GO:0003727; GO:0034154; GO:0034162; GO:0004888 Golgi membrane; I-kappaB phosphorylation; MyD88-dependent toll-like receptor signaling pathway; cellular response to mechanical stimulus; defense response to virus; double-stranded RNA binding; drug binding; early phagosome; endolysosome membrane; endoplasmic reticulum membrane; inflammatory response; innate immune response; integral to membrane; microglial cell activation involved in immune response; pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response; plasma membrane; positive regulation of NF-kappaB import into nucleus; positive regulation of chemokine production; positive regulation of inflammatory response; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-6 production; positive regulation of interleukin-8 biosynthetic process; positive regulation of interleukin-8 production; response to chemical stimulus; siRNA binding; single-stranded RNA binding; toll-like receptor 7 signaling pathway; toll-like receptor 9 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000372; IPR026906; IPR000157; IPR026880; Toll-like receptor 7 TLR7 UNQ248/PRO285 Homo sapiens (Human) TR22345_c3_g2_i1 Q7TT36 GP125_MOUSE 4.00E-13 GO:0004930; GO:0009897; GO:0016021; GO:0007218 G-protein coupled receptor activity; external side of plasma membrane; integral to membrane; neuropeptide signaling pathway IPR000483; IPR017981; IPR001879; IPR000832; IPR000203; IPR007110; IPR013783; IPR013098; IPR003599; IPR001611; IPR003591; Probable G-protein coupled receptor 125 Gpr125 Mus musculus (Mouse) TR22347_c0_g1_i1 Q90600 RB_CHICK 7.00E-11 GO:0003677; GO:0007049; GO:0016568; GO:0019048; GO:0005634; GO:0051726; GO:0006357; GO:0006351 "DNA binding; cell cycle; chromatin modification; modulation by virus of host morphology or physiology; nucleus; regulation of cell cycle; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR013763; IPR015652; IPR002720; IPR002719; IPR015030; IPR028309; IPR024599; Retinoblastoma-associated protein (p104) (pRb) (Rb) RB1 Gallus gallus (Chicken) TR2235_c0_g1_i1 Q96MM6 HS12B_HUMAN 3.00E-07 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR22353_c0_g1_i1 Q5M929 RN135_RAT 1.00E-09 GO:0005737; GO:0045087; GO:0032728; GO:0045088; GO:0043021; GO:0004842; GO:0008270 cytoplasm; innate immune response; positive regulation of interferon-beta production; regulation of innate immune response; ribonucleoprotein complex binding; ubiquitin-protein ligase activity; zinc ion binding IPR001870; IPR003879; IPR008985; IPR006574; IPR003877; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF135 (EC 6.3.2.-) (RING finger protein 135) Rnf135 Rattus norvegicus (Rat) TR22362_c0_g1_i1 Q8BZW4 ZN120_MOUSE 2.00E-20 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 120 (Zinc finger protein 31) (mZF31) Zfp120 Mus musculus (Mouse) TR22362_c0_g2_i1 Q9EQJ4 ZN384_RAT 5.00E-16 GO:0017124; GO:0005925; GO:0046872; GO:0006913; GO:0005634; GO:0050714; GO:0045944; GO:0043565; GO:0006351 "SH3 domain binding; focal adhesion; metal ion binding; nucleocytoplasmic transport; nucleus; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 384 (Cas-associated zinc finger protein) (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) Znf384 Ciz Nmp4 Zfp384 Rattus norvegicus (Rat) TR22362_c1_g1_i1 P17036 ZNF3_HUMAN 6.00E-18 GO:0003677; GO:0030154; GO:0045321; GO:0007275; GO:0005634; GO:0003700; GO:0006351; GO:0008270 Itself; Q9UDV6 "DNA binding; cell differentiation; leukocyte activation; multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 3 (Zinc finger protein HF.12) (Zinc finger protein HZF3.1) (Zinc finger protein KOX25) ZNF3 KOX25 Homo sapiens (Human) TR22362_c1_g1_i2 Q02027 ESCA_PSYCI 4.00E-06 GO:0003677; GO:0046872; GO:0005634 DNA binding; metal ion binding; nucleus IPR007087; IPR015880; IPR013087; Escargot/snail protein homolog (Fragment) Psychoda cinerea (Psychod fly) TR22363_c0_g1_i1 Q3V1L4 5NTC_MOUSE 7.00E-57 GO:0008253; GO:0005737; GO:0046872; GO:0000166; GO:0009117 5'-nucleotidase activity; cytoplasm; metal ion binding; nucleotide binding; nucleotide metabolic process IPR023214; IPR008380; IPR016695; Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (Cytosolic 5'-nucleotidase II) Nt5c2 Mus musculus (Mouse) TR22364_c0_g1_i1 Q62217 SEM5A_MOUSE 2.00E-08 GO:0008046; GO:0016021; GO:0001569 axon guidance receptor activity; integral to membrane; patterning of blood vessels IPR016201; IPR002165; IPR001627; IPR027231; IPR000884; IPR015943; Semaphorin-5A (Semaphorin-F) (Sema F) Sema5a Semaf SemF Mus musculus (Mouse) TR22364_c0_g2_i1 Q13591 SEM5A_HUMAN 3.00E-09 GO:0007411; GO:0008046; GO:0007155; GO:0007267; GO:0016021; GO:0001569; GO:0005886 axon guidance; axon guidance receptor activity; cell adhesion; cell-cell signaling; integral to membrane; patterning of blood vessels; plasma membrane IPR016201; IPR002165; IPR001627; IPR027231; IPR000884; IPR015943; Semaphorin-5A (Semaphorin-F) (Sema F) SEMA5A SEMAF Homo sapiens (Human) TR22365_c0_g1_i1 O77081 TPSTA_CAEEL 2.00E-54 GO:0000139; GO:0032963; GO:0042338; GO:0016021; GO:0006478; GO:0008476; GO:0040012; GO:0061062; GO:0005802 Golgi membrane; collagen metabolic process; cuticle development involved in collagen and cuticulin-based cuticle molting cycle; integral to membrane; peptidyl-tyrosine sulfation; protein-tyrosine sulfotransferase activity; regulation of locomotion; regulation of nematode larval development; trans-Golgi network IPR027417; IPR026634; Protein-tyrosine sulfotransferase A (EC 2.8.2.20) (Tyrosylprotein sulfotransferase A) (TPST-A) tpst-1 Y111B2A.15 Caenorhabditis elegans TR22365_c1_g2_i1 A8XLL3 TPSTB_CAEBR 2.00E-21 GO:0006478; GO:0008476 peptidyl-tyrosine sulfation; protein-tyrosine sulfotransferase activity IPR027417; IPR026634; Putative protein-tyrosine sulfotransferase (EC 2.8.2.20) (Tyrosylprotein sulfotransferase) (TPST) tpst-2 CBG15241 Caenorhabditis briggsae TR22366_c0_g1_i1 Q7TNF8 RIMB1_MOUSE 8.00E-32 GO:0005739 mitochondrion IPR003961; IPR011511; IPR001452; Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIMS-binding protein 1) (RIM-BP1) Bzrap1 Kiaa0612 Rbp1 Mus musculus (Mouse) TR22372_c1_g1_i1 Q9FT51 AB27G_ARATH 7.00E-18 GO:0005524; GO:0006200; GO:0016887; GO:0016021; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; integral to membrane; transport IPR003593; IPR013525; IPR003439; IPR017871; IPR027417; ABC transporter G family member 27 (ABC transporter ABCG.27) (AtABCG27) (Probable white-brown complex homolog protein 28) (AtWBC28) ABCG27 WBC28 At3g52310 T25B15.80 Arabidopsis thaliana (Mouse-ear cress) TR22375_c1_g1_i1 Q01974 ROR2_HUMAN 3.00E-14 GO:0005524; GO:0007254; GO:0007223; GO:0060071; GO:0001502; GO:0030154; GO:0030538; GO:0042472; GO:0005887; GO:0007275; GO:0090090; GO:0008285; GO:0090263; GO:0030335; GO:0045893; GO:0001756; GO:0004714; GO:0007169 P08238 "ATP binding; JNK cascade; Wnt receptor signaling pathway, calcium modulating pathway; Wnt receptor signaling pathway, planar cell polarity pathway; cartilage condensation; cell differentiation; embryonic genitalia morphogenesis; inner ear morphogenesis; integral to plasma membrane; multicellular organismal development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of cell proliferation; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell migration; positive regulation of transcription, DNA-dependent; somitogenesis; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway" IPR020067; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000001; IPR013806; IPR018056; IPR000719; IPR001245; IPR008266; IPR020635; IPR016247; "Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2)" ROR2 NTRKR2 Homo sapiens (Human) TR22379_c0_g1_i1 Q9VE46 SC5A7_DROME 2.00E-62 GO:0008292; GO:0015171; GO:0015220; GO:0016021; GO:0006814; GO:0015293 acetylcholine biosynthetic process; amino acid transmembrane transporter activity; choline transmembrane transporter activity; integral to membrane; sodium ion transport; symporter activity IPR001734; High-affinity choline transporter 1 CG7708 Drosophila melanogaster (Fruit fly) TR22386_c4_g1_i1 Q96IZ5 RBM41_HUMAN 5.00E-37 GO:0003723; GO:0000166 RNA binding; nucleotide binding IPR012677; IPR000504; RNA-binding protein 41 (RNA-binding motif protein 41) RBM41 Homo sapiens (Human) TR22389_c0_g1_i2 Q9W1A4 TAMO_DROME 2.00E-11 GO:0005737; GO:0007275; GO:0015031; GO:0008270 P15330 cytoplasm; multicellular organismal development; protein transport; zinc ion binding IPR018997; IPR001876; Protein tamozhennic tamo CG4057 Drosophila melanogaster (Fruit fly) TR22390_c0_g1_i1 O06851 SYV_STRCO 6.00E-58 GO:0005524; GO:0002161; GO:0005737; GO:0006450; GO:0004832; GO:0006438 ATP binding; aminoacyl-tRNA editing activity; cytoplasm; regulation of translational fidelity; valine-tRNA ligase activity; valyl-tRNA aminoacylation IPR001412; IPR002300; IPR014729; IPR010978; IPR009080; IPR013155; IPR019499; IPR009008; IPR002303; Valine--tRNA ligase (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) valS SCO2615 SCC88.26c Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) TR22390_c0_g2_i1 Q04462 SYVC_RAT 0 GO:0005524; GO:0002161; GO:0006450; GO:0004832; GO:0006438 ATP binding; aminoacyl-tRNA editing activity; regulation of translational fidelity; valine-tRNA ligase activity; valyl-tRNA aminoacylation IPR001412; IPR002300; IPR010987; IPR004045; IPR004046; IPR014729; IPR009080; IPR013155; IPR009008; IPR002303; Valine--tRNA ligase (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) Vars Vars2 Rattus norvegicus (Rat) TR22395_c0_g2_i1 Q8BIG4 FBX28_MOUSE 1.00E-38 IPR001810; F-box only protein 28 Fbxo28 D1Ertd578e Kiaa0483 Mus musculus (Mouse) TR2240_c0_g1_i1 Q5U249 ELYS_XENLA 3.00E-14 GO:0003677; GO:0051028; GO:0005643; GO:0015031 DNA binding; mRNA transport; nuclear pore; protein transport IPR017956; IPR025151; IPR011047; IPR001680; Protein ELYS (Protein MEL-28) (xELYS) ahctf1 elys Xenopus laevis (African clawed frog) TR22400_c0_g1_i1 Q8I7C3 LASP1_DROME 6.00E-08 GO:0003779; GO:0005925; GO:0007279; GO:0045856; GO:0007291; GO:0070864; GO:0008270 actin binding; focal adhesion; pole cell formation; positive regulation of pole plasm oskar mRNA localization; sperm individualization; sperm individualization complex; zinc ion binding IPR000900; IPR001452; IPR001781; LIM and SH3 domain protein Lasp Lasp CG3849 Drosophila melanogaster (Fruit fly) TR22409_c1_g1_i1 Q62130 PTN14_MOUSE 1.00E-38 GO:0005737; GO:0005856; GO:0001946; GO:0008285; GO:0005634; GO:0004725; GO:0046825; GO:0006355; GO:0003712; GO:0006351 "cytoplasm; cytoskeleton; lymphangiogenesis; negative regulation of cell proliferation; nucleus; protein tyrosine phosphatase activity; regulation of protein export from nucleus; regulation of transcription, DNA-dependent; transcription cofactor activity; transcription, DNA-dependent" IPR019749; IPR019750; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; IPR000387; IPR016130; IPR014392; IPR000242; Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36) Ptpn14 Mus musculus (Mouse) TR22421_c0_g1_i1 Q8K3J1 NDUS8_MOUSE 3.00E-09 GO:0051539; GO:0008137; GO:0046872; GO:0005747; GO:0032981; GO:0005739; GO:0006979 "4 iron, 4 sulfur cluster binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; mitochondrial respiratory chain complex I; mitochondrial respiratory chain complex I assembly; mitochondrion; response to oxidative stress" IPR001450; IPR017896; IPR017900; IPR010226; "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-23kD) (CI-23kD) (NADH-ubiquinone oxidoreductase 23 kDa subunit)" Ndufs8 Mus musculus (Mouse) TR22422_c2_g1_i1 Q13263 TIF1B_HUMAN 1.00E-07 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR22429_c0_g1_i1 P51399 LOX5_MESAU 5.00E-18 GO:0004051; GO:0005829; GO:0005506; GO:0019370; GO:0005641; GO:0016363; GO:0031965 arachidonate 5-lipoxygenase activity; cytosol; iron ion binding; leukotriene biosynthetic process; nuclear envelope lumen; nuclear matrix; nuclear membrane IPR008976; IPR000907; IPR013819; IPR020834; IPR020833; IPR001885; IPR001024; Lipid metabolism; leukotriene A4 biosynthesis. Arachidonate 5-lipoxygenase (5-LO) (5-lipoxygenase) (EC 1.13.11.34) ALOX5 Mesocricetus auratus (Golden hamster) TR22429_c0_g1_i2 P09917 LOX5_HUMAN 4.00E-18 GO:0004051; GO:0019369; GO:0005829; GO:0005506; GO:0019370; GO:0002540; GO:2001300; GO:0019372; GO:0005641; GO:0016363; GO:0031965 Q14019 arachidonate 5-lipoxygenase activity; arachidonic acid metabolic process; cytosol; iron ion binding; leukotriene biosynthetic process; leukotriene production involved in inflammatory response; lipoxin metabolic process; lipoxygenase pathway; nuclear envelope lumen; nuclear matrix; nuclear membrane IPR008976; IPR000907; IPR013819; IPR020834; IPR020833; IPR001885; IPR001024; Lipid metabolism; leukotriene A4 biosynthesis. Arachidonate 5-lipoxygenase (5-LO) (5-lipoxygenase) (EC 1.13.11.34) ALOX5 LOG5 Homo sapiens (Human) TR22430_c2_g3_i1 Q6DFV1 CNDG2_MOUSE 2.00E-16 GO:0051301; GO:0030261; GO:0001833; GO:0007067; GO:0005634 cell division; chromosome condensation; inner cell mass cell proliferation; mitosis; nucleus IPR011989; IPR016024; IPR024741; Condensin-2 complex subunit G2 (Chromosome-associated protein G2) (CAP-G2) (Leucine zipper protein 5) (More than blood protein) (Non-SMC condensin II complex subunit G2) Ncapg2 Luzp5 Mtb Mus musculus (Mouse) TR22436_c0_g1_i1 Q9NUV9 GIMA4_HUMAN 7.00E-38 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR22444_c0_g1_i1 O43301 HS12A_HUMAN 2.00E-43 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR22446_c0_g1_i1 Q803C9 PTSS1_DANRE 1.00E-57 GO:0005789; GO:0016021; GO:0006659; GO:0016740 endoplasmic reticulum membrane; integral to membrane; phosphatidylserine biosynthetic process; transferase activity IPR004277; Phospholipid metabolism; phosphatidylserine biosynthesis. Phosphatidylserine synthase 1 (PSS-1) (PtdSer synthase 1) (EC 2.7.8.29) (Serine-exchange enzyme I) ptdss1 si:ch211-269k10 zgc:55906 Danio rerio (Zebrafish) (Brachydanio rerio) TR22448_c3_g1_i1 O05389 YRBE_BACSU 1.00E-09 GO:0016491 oxidoreductase activity IPR016040; IPR000683; IPR004104; Uncharacterized oxidoreductase YrbE (EC 1.-.-.-) yrbE BSU27770 Bacillus subtilis (strain 168) TR22453_c1_g1_i2 Q96P09 BIRC8_HUMAN 8.00E-06 GO:0005829; GO:0043154; GO:0043524; GO:0005634; GO:0048471; GO:0043234; GO:0008270 cytosol; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of neuron apoptotic process; nucleus; perinuclear region of cytoplasm; protein complex; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis-like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis) BIRC8 ILP2 Homo sapiens (Human) TR22453_c1_g1_i4 A2AWP0 BIRC7_MOUSE 3.00E-11 GO:0005794; GO:0006915; GO:0004869; GO:0043066; GO:0005634; GO:0042127; GO:0070247; GO:0004842; GO:0008270 Golgi apparatus; apoptotic process; cysteine-type endopeptidase inhibitor activity; negative regulation of apoptotic process; nucleus; regulation of cell proliferation; regulation of natural killer cell apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; IPR017907; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (Livin) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30 kDa subunit (Truncated livin) (p30-Livin) (tLivin)] Birc7 Livin Mus musculus (Mouse) TR2246_c0_g1_i1 Q96I24 FUBP3_HUMAN 3.00E-22 GO:0003677; GO:0003723; GO:0005737; GO:0005634; GO:0045893; GO:0006351 "DNA binding; RNA binding; cytoplasm; nucleus; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR004087; IPR004088; Far upstream element-binding protein 3 (FUSE-binding protein 3) FUBP3 FBP3 Homo sapiens (Human) TR22473_c0_g1_i1 P39963 CCNB3_CHICK 1.00E-31 GO:0007049; GO:0051301; GO:0005634; GO:0010389; GO:0000079 cell cycle; cell division; nucleus; regulation of G2/M transition of mitotic cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity IPR013763; IPR014400; IPR015452; IPR004367; IPR006671; G2/mitotic-specific cyclin-B3 CCNB3 CYCB3 Gallus gallus (Chicken) TR22476_c1_g1_i2 A2ASS6 TITIN_MOUSE 6.00E-07 GO:0005524; GO:0031430; GO:0030018; GO:0007512; GO:0055003; GO:0043056; GO:0003007; GO:0001701; GO:0046872; GO:0006936; GO:0005859; GO:0005634; GO:0018108; GO:0004674; GO:0004713; GO:1901897; GO:0045214; GO:0001756; GO:0005200 ATP binding; M band; Z disc; adult heart development; cardiac myofibril assembly; forward locomotion; heart morphogenesis; in utero embryonic development; metal ion binding; muscle contraction; muscle myosin complex; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of relaxation of cardiac muscle; sarcomere organization; somitogenesis; structural constituent of cytoskeleton IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) TR22477_c0_g1_i1 Q9NVI1 FANCI_HUMAN 3.00E-36 GO:0003677; GO:0006281; GO:0007049; GO:0005654; GO:0005886; GO:0031398 Q9BXW9 DNA binding; DNA repair; cell cycle; nucleoplasm; plasma membrane; positive regulation of protein ubiquitination IPR026171; Fanconi anemia group I protein (Protein FACI) FANCI KIAA1794 Homo sapiens (Human) TR22478_c0_g1_i1 P46405 RS12_PIG 2.00E-72 GO:0022627; GO:0003735; GO:0006412 cytosolic small ribosomal subunit; structural constituent of ribosome; translation IPR004038; IPR000530; 40S ribosomal protein S12 RPS12 Sus scrofa (Pig) TR22486_c0_g1_i1 P46013 KI67_HUMAN 1.00E-19 GO:0005524; GO:0006259; GO:0008283; GO:0034605; GO:0000775; GO:0000793; GO:0005737; GO:0007126; GO:0005730; GO:0031100 "ATP binding; DNA metabolic process; cell proliferation; cellular response to heat; chromosome, centromeric region; condensed chromosome; cytoplasm; meiosis; nucleolus; organ regeneration" IPR000253; IPR012568; IPR008984; Antigen KI-67 MKI67 Homo sapiens (Human) TR22488_c0_g1_i1 Q5CAZ6 B3GA2_CANFA 6.00E-64 GO:0000139; GO:0015018; GO:0016021; GO:0046872; GO:0006486 Golgi membrane; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity; integral to membrane; metal ion binding; protein glycosylation IPR005027; Protein modification; protein glycosylation. "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 2) (GlcAT-D) (UDP-glucuronosyltransferase S) (GlcAT-S) (Glucuronosyltransferase S)" B3GAT2 Canis familiaris (Dog) (Canis lupus familiaris) TR22490_c0_g1_i2 Q7LZR2 CO8A1_CHICK 6.00E-09 GO:0001525; GO:0005604; GO:0007155; GO:0005581 angiogenesis; basement membrane; cell adhesion; collagen IPR001073; IPR008160; IPR008983; Collagen alpha-1(VIII) chain COL8A1 Gallus gallus (Chicken) TR22496_c0_g1_i2 Q8HXB8 RL29_MACFA 8.00E-20 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR002673; 60S ribosomal protein L29 RPL29 QccE-11892 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR22499_c0_g1_i1 B3A0Q8 PLSP2_LOTGI 4.00E-11 GO:0005576; GO:0020037; GO:0004601; GO:0006979 extracellular region; heme binding; peroxidase activity; response to oxidative stress IPR010255; IPR002007; IPR019791; Peroxidase-like protein 3 (Fragment) Lottia gigantea (Giant owl limpet) TR22499_c1_g1_i1 P14650 PERT_RAT 1.00E-20 GO:0005509; GO:0009986; GO:0071732; GO:0020037; GO:0042446; GO:0042744; GO:0016021; GO:0004447; GO:0005886; GO:0033993; GO:0006590 calcium ion binding; cell surface; cellular response to nitric oxide; heme binding; hormone biosynthetic process; hydrogen peroxide catabolic process; integral to membrane; iodide peroxidase activity; plasma membrane; response to lipid; thyroid hormone generation IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR010255; IPR002007; IPR019791; IPR000436; Hormone biosynthesis; thyroid hormone biosynthesis. Thyroid peroxidase (TPO) (EC 1.11.1.8) Tpo Rattus norvegicus (Rat) TR22499_c5_g1_i1 Q01603 PERO_DROME 2.00E-12 GO:0042600; GO:0007306; GO:0005576; GO:0020037; GO:0042744; GO:0046872; GO:0022008; GO:0004601; GO:0006909 chorion; eggshell chorion assembly; extracellular region; heme binding; hydrogen peroxide catabolic process; metal ion binding; neurogenesis; peroxidase activity; phagocytosis IPR010255; IPR002007; IPR019791; Peroxidase (DmPO) (EC 1.11.1.7) (Chorion peroxidase) Pxd HDC14047 PO CG3477 Drosophila melanogaster (Fruit fly) TR22503_c1_g1_i1 Q96NL1 TMM74_HUMAN 1.00E-09 GO:0000421; GO:0006914; GO:0031410; GO:0016021; GO:0005765 autophagic vacuole membrane; autophagy; cytoplasmic vesicle; integral to membrane; lysosomal membrane Transmembrane protein 74 TMEM74 Homo sapiens (Human) TR22508_c1_g1_i1 O49561 G2OX8_ARATH 2.00E-14 GO:0052635; GO:0009686; GO:0009685; GO:0046872 C-20 gibberellin 2-beta-dioxygenase activity; gibberellin biosynthetic process; gibberellin metabolic process; metal ion binding IPR026992; IPR027443; IPR005123; Plant hormone biosynthesis; gibberellin biosynthesis. Gibberellin 2-beta-dioxygenase 8 (EC 1.14.11.13) (GA 2-oxidase 8) (Gibberellin 2-beta-hydroxylase 8) (Gibberellin 2-oxidase 8) GA2OX8 At4g21200 F7J7.140 Arabidopsis thaliana (Mouse-ear cress) TR22508_c1_g2_i1 Q9XG83 G2OX_PHACN 8.00E-18 GO:0045543; GO:0009686; GO:0005506 gibberellin 2-beta-dioxygenase activity; gibberellin biosynthetic process; iron ion binding IPR026992; IPR027443; IPR002283; IPR005123; Plant hormone biosynthesis; gibberellin biosynthesis. Gibberellin 2-beta-dioxygenase (EC 1.14.11.13) (GA 2-oxidase) (Gibberellin 2-beta-hydroxylase) (Gibberellin 2-oxidase) GA2OX1 Phaseolus coccineus (Scarlet runner bean) (Phaseolus multiflorus) TR22517_c1_g1_i1 Q1H9T6 ZBT48_MOUSE 2.00E-16 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 48 (Krueppel-related zinc finger protein 3) (Protein HKR3) Zbtb48 Hkr3 Mus musculus (Mouse) TR2252_c0_g1_i1 Q6PDJ1 CAHD1_MOUSE 2.00E-24 GO:0006816; GO:0016021 calcium ion transport; integral to membrane IPR004010; IPR013608; IPR002035; VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) TR22523_c0_g2_i1 P05934 CALM_STRPU 5.00E-09 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) (Fragment) Strongylocentrotus purpuratus (Purple sea urchin) TR22525_c1_g1_i2 Q4R9C4 G2E3_MACFA 8.00E-07 GO:0006915; GO:0005737; GO:0007275; GO:0005730; GO:0004842; GO:0008270 apoptotic process; cytoplasm; multicellular organismal development; nucleolus; ubiquitin-protein ligase activity; zinc ion binding IPR000569; IPR019786; IPR011011; IPR001965; IPR001841; IPR013083; Protein modification; protein ubiquitination. G2/M phase-specific E3 ubiquitin-protein ligase (EC 6.3.2.-) G2E3 QtsA-15505 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR22528_c2_g1_i1 A0JP43 EFCB5_MOUSE 2.00E-55 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR003018; EF-hand calcium-binding domain-containing protein 5 Efcab5 Mus musculus (Mouse) TR22530_c0_g1_i1 Q5TUE9 RM23_ANOGA 1.00E-23 GO:0005739; GO:0000166; GO:0005840; GO:0003735; GO:0006412 mitochondrion; nucleotide binding; ribosome; structural constituent of ribosome; translation IPR012677; IPR012678; IPR013025; "Probable 39S ribosomal protein L23, mitochondrial (L23mt) (MRP-L23)" mRpL23 AGAP010338 Anopheles gambiae (African malaria mosquito) TR22533_c0_g3_i1 Q92576 PHF3_HUMAN 3.00E-34 GO:0007275; GO:0005634; GO:0006351; GO:0008270 "multicellular organismal development; nucleus; transcription, DNA-dependent; zinc ion binding" IPR012921; IPR003618; IPR017890; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; PHD finger protein 3 PHF3 KIAA0244 Homo sapiens (Human) TR22548_c0_g1_i1 Q9PUB4 CP26A_CHICK 3.00E-13 GO:0005789; GO:0020037; GO:0005506; GO:0004497; GO:0016705; GO:0034653 "endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; retinoic acid catabolic process" IPR001128; IPR017972; IPR002403; Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-degrading enzyme CYP26) CYP26A1 CYP26 Gallus gallus (Chicken) TR22551_c2_g1_i1 Q5SYL1 SG494_MOUSE 6.00E-22 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR008271; Uncharacterized serine/threonine-protein kinase SgK494 (EC 2.7.11.1) (Sugen kinase 494) Sgk494 Mus musculus (Mouse) TR22551_c3_g1_i1 Q9Y1J3 PDPK1_CAEEL 7.00E-06 GO:0005524; GO:0030424; GO:0005737; GO:0040024; GO:0007611; GO:0043025; GO:0005634; GO:0005543; GO:0004674; GO:0050920 ATP binding; axon; cytoplasm; dauer larval development; learning or memory; neuronal cell body; nucleus; phospholipid binding; protein serine/threonine kinase activity; regulation of chemotaxis IPR011009; IPR011993; IPR001849; IPR000719; IPR002290; IPR008271; 3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (Pdk-class protein kinase 1) pdk-1 H42K12.1 Caenorhabditis elegans TR22551_c3_g2_i1 P10665 KS6AA_XENLA 1.00E-34 GO:0005524; GO:0007243; GO:0000287; GO:0004674 ATP binding; intracellular protein kinase cascade; magnesium ion binding; protein serine/threonine kinase activity IPR000961; IPR011009; IPR017892; IPR000719; IPR017441; IPR016239; IPR002290; IPR008271; Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (p90-RSK) rps6ka Xenopus laevis (African clawed frog) TR22551_c3_g3_i1 Q9LFA2 KIPK_ARATH 1.00E-11 GO:0005524; GO:0005737; GO:0005634; GO:0004672; GO:0004674 Q9FHN8 ATP binding; cytoplasm; nucleus; protein kinase activity; protein serine/threonine kinase activity IPR011009; IPR000719; IPR002290; IPR008271; Serine/threonine-protein kinase KIPK (EC 2.7.11.1) (KCBP-interacting protein kinase) KIPK At3g52890 F8J2_60 Arabidopsis thaliana (Mouse-ear cress) TR22555_c0_g1_i1 Q9UW86 PP1_NEUCR 3.00E-79 GO:0000077; GO:0000076; GO:0030437; GO:0007114; GO:0005935; GO:0006873; GO:0007059; GO:0000778; GO:0005977; GO:0016576; GO:0005847; GO:0001400; GO:0007126; GO:0046872; GO:0007094; GO:0005730; GO:0034501; GO:0000164; GO:0004722; GO:0006364; GO:0006109; GO:0000903; GO:0031297; GO:0009408; GO:0005816; GO:0030847; GO:0030846 "DNA damage checkpoint; DNA replication checkpoint; ascospore formation; cell budding; cellular bud neck; cellular ion homeostasis; chromosome segregation; condensed nuclear chromosome kinetochore; glycogen metabolic process; histone dephosphorylation; mRNA cleavage and polyadenylation specificity factor complex; mating projection base; meiosis; metal ion binding; mitotic spindle assembly checkpoint; nucleolus; protein localization to kinetochore; protein phosphatase type 1 complex; protein serine/threonine phosphatase activity; rRNA processing; regulation of carbohydrate metabolic process; regulation of cell shape during vegetative growth phase; replication fork processing; response to heat; spindle pole body; termination of RNA polymerase II transcription, exosome-dependent; termination of RNA polymerase II transcription, poly(A)-coupled" IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1 (EC 3.1.3.16) ppp-1 NCU00043 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR22555_c1_g1_i1 Q627N3 GLC7B_CAEBR 1.00E-94 GO:0051301; GO:0016568; GO:0005737; GO:0007126; GO:0046872; GO:0007067; GO:0007275; GO:0005634; GO:0004721 cell division; chromatin modification; cytoplasm; meiosis; metal ion binding; mitosis; multicellular organismal development; nucleus; phosphoprotein phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1-beta (EC 3.1.3.16) (Glc seven-like phosphatase 2) gsp-2 CBG00598 Caenorhabditis briggsae TR22559_c1_g1_i1 Q5RGJ8 GNPTA_DANRE 6.00E-92 GO:0000139; GO:0003976; GO:0005509; GO:0030154; GO:0016021; GO:0005634 Golgi membrane; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; calcium ion binding; cell differentiation; integral to membrane; nucleus IPR010506; IPR021520; IPR018247; IPR002048; IPR000800; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (EC 2.7.8.17) (GlcNAc-1-phosphotransferase subunits alpha/beta) (Stealth protein gnptab) (UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta) [Cleaved into: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta] gnptab gnpta si:ch211-234f20.3 zgc:122985 Danio rerio (Zebrafish) (Brachydanio rerio) TR22564_c1_g1_i1 P33897 ABCD1_HUMAN 0 GO:0005524; GO:0042626; GO:0036109; GO:0005829; GO:0033540; GO:0005779; GO:0043651; GO:0042758; GO:0005739; GO:0048471; GO:0005325; GO:0015919; GO:0007031; GO:0042803; GO:0042760 Itself; P48410; P28288; P40855 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; alpha-linolenic acid metabolic process; cytosol; fatty acid beta-oxidation using acyl-CoA oxidase; integral to peroxisomal membrane; linoleic acid metabolic process; long-chain fatty acid catabolic process; mitochondrion; perinuclear region of cytoplasm; peroxisomal fatty-acyl-CoA transporter activity; peroxisomal membrane transport; peroxisome organization; protein homodimerization activity; very long-chain fatty acid catabolic process" IPR003593; IPR011527; IPR010509; IPR003439; IPR017871; IPR005283; IPR027417; ATP-binding cassette sub-family D member 1 (Adrenoleukodystrophy protein) (ALDP) ABCD1 ALD Homo sapiens (Human) TR22569_c0_g1_i1 Q9CQE2 TM223_MOUSE 4.00E-12 GO:0016021; GO:0005739 integral to membrane; mitochondrion IPR026100; Transmembrane protein 223 Tmem223 Mus musculus (Mouse) TR2257_c0_g1_i1 P10323 ACRO_HUMAN 7.00E-16 GO:0003677; GO:0005798; GO:0043159; GO:0002077; GO:0007190; GO:0004040; GO:0007339; GO:0005507; GO:0008144; GO:0005576; GO:0042806; GO:0005537; GO:0032504; GO:0043234; GO:0009607; GO:0048545; GO:0004252; GO:0008270 DNA binding; Golgi-associated vesicle; acrosomal matrix; acrosome matrix dispersal; activation of adenylate cyclase activity; amidase activity; binding of sperm to zona pellucida; copper ion binding; drug binding; extracellular region; fucose binding; mannose binding; multicellular organism reproduction; protein complex; response to biotic stimulus; response to steroid hormone stimulus; serine-type endopeptidase activity; zinc ion binding IPR012267; IPR001254; IPR018114; IPR001314; IPR009003; Acrosin (EC 3.4.21.10) [Cleaved into: Acrosin light chain; Acrosin heavy chain] ACR ACRS Homo sapiens (Human) TR22579_c0_g1_i1 P31423 GRM4_RAT 2.00E-19 GO:0004930; GO:0000187; GO:0007196; GO:0031410; GO:0043198; GO:0014051; GO:0008066; GO:0005887; GO:0043066; GO:0008285; GO:0050805; GO:0031175; GO:0048787; GO:0043523; GO:0051932; GO:0035249; GO:0043195 "G-protein coupled receptor activity; activation of MAPK activity; adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway; cytoplasmic vesicle; dendritic shaft; gamma-aminobutyric acid secretion; glutamate receptor activity; integral to plasma membrane; negative regulation of apoptotic process; negative regulation of cell proliferation; negative regulation of synaptic transmission; neuron projection development; presynaptic active zone membrane; regulation of neuron apoptotic process; synaptic transmission, GABAergic; synaptic transmission, glutamatergic; terminal bouton" IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR000162; IPR001786; IPR028082; Metabotropic glutamate receptor 4 (mGluR4) Grm4 Gprc1d Mglur4 Rattus norvegicus (Rat) TR22579_c0_g2_i1 Q925D8 TS1R3_MOUSE 2.00E-10 GO:0004930; GO:0005887; GO:0050916; GO:0050917; GO:0033041 G-protein coupled receptor activity; integral to plasma membrane; sensory perception of sweet taste; sensory perception of umami taste; sweet taste receptor activity IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR028082; Taste receptor type 1 member 3 (Saccharin preference protein) (Sweet taste receptor T1R3) Tas1r3 Sac T1r3 Tr3 Mus musculus (Mouse) TR22579_c2_g1_i1 P35349 GRM6_RAT 7.00E-21 GO:0000139; GO:0001640; GO:0030425; GO:0050908; GO:0005789; GO:0005887; GO:0007626; GO:0035841; GO:0090280; GO:0060041; GO:0007268 Golgi membrane; adenylate cyclase inhibiting G-protein coupled glutamate receptor activity; dendrite; detection of light stimulus involved in visual perception; endoplasmic reticulum membrane; integral to plasma membrane; locomotory behavior; new growing cell tip; positive regulation of calcium ion import; retina development in camera-type eye; synaptic transmission IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR000162; IPR000112; IPR028082; Metabotropic glutamate receptor 6 (mGluR6) Grm6 Gprc1f Mglur6 Rattus norvegicus (Rat) TR22581_c0_g1_i1 Q640K3 NCKP1_XENLA 2.00E-08 GO:0016021; GO:0031258 integral to membrane; lamellipodium membrane IPR019137; Nck-associated protein 1 (NAP 1) nckap1 Xenopus laevis (African clawed frog) TR22585_c0_g1_i1 Q9VCY8 ADRL_DROME 2.00E-06 GO:0019395; GO:0042593; GO:0042562; GO:0009755; GO:0016021; GO:0032024; GO:0070328 fatty acid oxidation; glucose homeostasis; hormone binding; hormone-mediated signaling pathway; integral to membrane; positive regulation of insulin secretion; triglyceride homeostasis IPR004254; ADIPOR-like receptor CG5315 CG5315 Drosophila melanogaster (Fruit fly) TR22585_c3_g1_i1 Q86WK9 MPRA_HUMAN 9.00E-26 GO:0030154; GO:0016021; GO:0007275; GO:0048477; GO:0005886; GO:0005496 cell differentiation; integral to membrane; multicellular organismal development; oogenesis; plasma membrane; steroid binding IPR004254; Membrane progestin receptor alpha (mPR alpha) (Progestin and adipoQ receptor family member 7) (Progestin and adipoQ receptor family member VII) PAQR7 MRPA Homo sapiens (Human) TR22589_c0_g1_i1 P24014 SLIT_DROME 2.00E-12 GO:0035385; GO:0071666; GO:0016199; GO:0005509; GO:0048813; GO:0007502; GO:0035050; GO:0007427; GO:0008347; GO:0008406; GO:0008201; GO:0050929; GO:0046331; GO:0008078; GO:0001764; GO:0003151; GO:0005886; GO:0022409; GO:0005578; GO:2000274; GO:0007432 "Roundabout signaling pathway; Slit-Robo signaling complex; axon midline choice point recognition; calcium ion binding; dendrite morphogenesis; digestive tract mesoderm development; embryonic heart tube development; epithelial cell migration, open tracheal system; glial cell migration; gonad development; heparin binding; induction of negative chemotaxis; lateral inhibition; mesodermal cell migration; neuron migration; outflow tract morphogenesis; plasma membrane; positive regulation of cell-cell adhesion; proteinaceous extracellular matrix; regulation of epithelial cell migration, open tracheal system; salivary gland boundary specification" IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; IPR026906; Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) TR22591_c0_g1_i1 Q6PC64 ELOV6_DANRE 3.00E-73 GO:0005783; GO:0005789; GO:0019367; GO:0016021; GO:0042759; GO:0016740 "endoplasmic reticulum; endoplasmic reticulum membrane; fatty acid elongation, saturated fatty acid; integral to membrane; long-chain fatty acid biosynthetic process; transferase activity" IPR002076; Elongation of very long chain fatty acids protein 6 (EC 2.3.1.199) (3-keto acyl-CoA synthase elovl6) (ELOVL fatty acid elongase 6) (ELOVL FA elongase 6) (Very-long-chain 3-oxoacyl-CoA synthase 6) elovl6 Danio rerio (Zebrafish) (Brachydanio rerio) TR22592_c3_g1_i1 Q90404 AGRIN_DISOM 4.00E-07 GO:0030154; GO:0007275 cell differentiation; multicellular organismal development IPR008985; IPR013320; IPR000742; IPR013032; IPR000152; IPR002049; IPR003645; IPR002350; IPR001791; IPR000082; Agrin (Fragment) AGRN AGRIN Diplobatis ommata (Ocellated electric ray) (Discopyge ommata) TR22593_c0_g1_i1 Q91WS7 DEPD7_MOUSE 8.00E-54 GO:0035556 intracellular signal transduction IPR000591; IPR011991; DEP domain-containing protein 7 (Protein TR2/D15) Depdc7 Mus musculus (Mouse) TR22596_c0_g1_i1 A6QQ21 CSN6_BOVIN 2.00E-145 GO:0008180; GO:0005737 COP9 signalosome; cytoplasm IPR000555; IPR024969; COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) COPS6 Bos taurus (Bovine) TR22601_c1_g1_i1 H2A0L0 TYRO1_PINMG 2.00E-44 GO:0005576; GO:0046872; GO:0016491 extracellular region; metal ion binding; oxidoreductase activity IPR002227; IPR008922; Tyrosinase-like protein 1 (EC 1.14.18.-) (Tyrosinase 1) Pinctada margaritifera (Black-lipped pearl oyster) TR22604_c0_g1_i1 Q9WVB4 SLIT3_MOUSE 3.00E-08 GO:0035385; GO:0061364; GO:0048846; GO:0007411; GO:0005509; GO:0032870; GO:0005615; GO:0050919; GO:0030308; GO:0008285; GO:0070100; GO:0010629; GO:0009887; GO:0005102; GO:0051414 Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; axon guidance; calcium ion binding; cellular response to hormone stimulus; extracellular space; negative chemotaxis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of chemokine-mediated signaling pathway; negative regulation of gene expression; organ morphogenesis; receptor binding; response to cortisol stimulus IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 3 protein (Slit-3) (Slit3) Slit3 Mus musculus (Mouse) TR22614_c3_g1_i1 Q9UN72 PCDA7_HUMAN 7.00E-09 GO:0005509; GO:0007155; GO:0007156; GO:0005887; GO:0007399 calcium ion binding; cell adhesion; homophilic cell adhesion; integral to plasma membrane; nervous system development IPR002126; IPR015919; IPR020894; IPR013164; Protocadherin alpha-7 (PCDH-alpha-7) PCDHA7 CNRS4 Homo sapiens (Human) TR22614_c4_g1_i1 Q6B457 CDHR1_XENLA 2.00E-06 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; Cadherin-related family member 1 (Photoreceptor cadherin) (prCAD) (Protocadherin-21) cdhr1 pcdh21 prcad Xenopus laevis (African clawed frog) TR22623_c1_g1_i1 Q54S12 TM104_DICDI 3.00E-08 GO:0016021 integral to membrane IPR013057; Transmembrane protein 104 homolog tmem104 DDB_G0282723 Dictyostelium discoideum (Slime mold) TR22623_c3_g1_i1 Q8NE00 TM104_HUMAN 1.00E-29 GO:0016021 integral to membrane IPR013057; Transmembrane protein 104 TMEM104 Homo sapiens (Human) TR22630_c0_g1_i1 Q6AXY2 CF201_RAT 1.00E-05 IPR027827; Uncharacterized protein C6orf201 homolog Rattus norvegicus (Rat) TR22631_c0_g1_i2 Q0Q028 DFP3_ANTMY 6.00E-10 GO:0042742; GO:0042832; GO:0005576; GO:0045087 defense response to bacterium; defense response to protozoan; extracellular region; innate immune response IPR002861; Putative defense protein 3 (DFP-3) Antheraea mylitta (Tasar silkworm) TR22633_c3_g1_i1 Q9NS00 C1GLT_HUMAN 3.00E-09 GO:0000139; GO:0016266; GO:0001525; GO:0030154; GO:0016263; GO:0016021; GO:0001822; GO:0046872; GO:0043687 Q96EU7 Golgi membrane; O-glycan processing; angiogenesis; cell differentiation; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity; integral to membrane; kidney development; metal ion binding; post-translational protein modification IPR026842; IPR003378; Protein modification; protein glycosylation. "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (B3Gal-T8) (Core 1 O-glycan T-synthase) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Beta-1,3-galactosyltransferase) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1)" C1GALT1 Homo sapiens (Human) TR22633_c4_g1_i2 Q8BHT6 B3GLT_MOUSE 3.00E-51 GO:0005789; GO:0006004; GO:0016021; GO:0006486; GO:0016757 "endoplasmic reticulum membrane; fucose metabolic process; integral to membrane; protein glycosylation; transferase activity, transferring glycosyl groups" IPR003378; Protein modification; protein glycosylation. "Beta-1,3-glucosyltransferase (Beta3Glc-T) (EC 2.4.1.-) (Beta-3-glycosyltransferase-like)" B3galtl Gm1057 Mus musculus (Mouse) TR22635_c0_g1_i1 P58743 S26A5_HUMAN 2.00E-19 GO:0016323; GO:0016021; GO:0016328; GO:0008360; GO:0042391; GO:0008271; GO:0007605; GO:0008272 basolateral plasma membrane; integral to membrane; lateral plasma membrane; regulation of cell shape; regulation of membrane potential; secondary active sulfate transmembrane transporter activity; sensory perception of sound; sulfate transport IPR018045; IPR002645; IPR001902; IPR011547; Prestin (Solute carrier family 26 member 5) SLC26A5 PRES Homo sapiens (Human) TR22637_c1_g1_i2 O95714 HERC2_HUMAN 4.00E-10 GO:0006281; GO:0032183; GO:0005814; GO:0005737; GO:0005085; GO:0020037; GO:0006886; GO:0005634; GO:0042787; GO:0004842; GO:0008270 DNA repair; SUMO binding; centriole; cytoplasm; guanyl-nucleotide exchange factor activity; heme binding; intracellular protein transport; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR004939; IPR006624; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) HERC2 Homo sapiens (Human) TR22638_c5_g1_i1 O95427 PIGN_HUMAN 4.00E-61 GO:0006501; GO:0005789; GO:0016021; GO:0016254; GO:0016740 C-terminal protein lipidation; endoplasmic reticulum membrane; integral to membrane; preassembly of GPI anchor in ER membrane; transferase activity IPR017849; IPR017850; IPR007070; IPR017852; IPR002591; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (MCD4 homolog) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N) PIGN MCD4 Homo sapiens (Human) TR22643_c4_g1_i3 Q02241 KIF23_HUMAN 6.00E-29 GO:0005524; GO:0019886; GO:0007596; GO:0097149; GO:0005813; GO:0000910; GO:0005829; GO:0045171; GO:0005871; GO:0005874; GO:0008017; GO:0003777; GO:0007018; GO:0030496; GO:0000022; GO:0005654; GO:0032467; GO:0051256 P62330; P62331; Q9NR09; Q9H0H5; P63104 ATP binding; antigen processing and presentation of exogenous peptide antigen via MHC class II; blood coagulation; centralspindlin complex; centrosome; cytokinesis; cytosol; intercellular bridge; kinesin complex; microtubule; microtubule binding; microtubule motor activity; microtubule-based movement; midbody; mitotic spindle elongation; nucleoplasm; positive regulation of cytokinesis; spindle midzone assembly involved in mitosis IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) KIF23 KNSL5 MKLP1 Homo sapiens (Human) TR22650_c1_g1_i1 H2A0M0 NRP_PINMG 2.00E-06 GO:0005576 extracellular region IPR008985; Asparagine-rich protein (Prism uncharacterized shell protein 1) (PUSP1) Pinctada margaritifera (Black-lipped pearl oyster) TR22653_c1_g1_i1 Q9NRA2 S17A5_HUMAN 6.00E-58 GO:0006865; GO:0030054; GO:0005887; GO:0005765; GO:0015136; GO:0015739; GO:0005351; GO:0030672 amino acid transport; cell junction; integral to plasma membrane; lysosomal membrane; sialic acid transmembrane transporter activity; sialic acid transport; sugar:hydrogen symporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) TR22659_c0_g1_i1 P02213 GLB1_ANAIN 3.00E-15 GO:0005737; GO:0020037; GO:0005506; GO:0019825; GO:0005344 cytoplasm; heme binding; iron ion binding; oxygen binding; oxygen transporter activity IPR000971; IPR009050; IPR012292; Globin-1 (Dimeric hemoglobin) (Globin I) (HbI) Anadara inaequivalvis (Inequivalve ark) (Scapharca inaequivalvis) TR22659_c0_g1_i2 P0C227 GLB_NERAL 7.00E-16 GO:0005576; GO:0020037; GO:0005833; GO:0005506; GO:0019825; GO:0005344 extracellular region; heme binding; hemoglobin complex; iron ion binding; oxygen binding; oxygen transporter activity IPR002336; IPR000971; IPR009050; IPR012292; Globin (Myoglobin) Nerita albicilla (Ox-palate nerite) (Theliostyla albicilla) TR22661_c1_g1_i1 O00303 EIF3F_HUMAN 7.00E-77 GO:0008234; GO:0005829; GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0006508; GO:0006446; GO:0003743 P21127; P55884; Q969P5; Q9Q2G4 cysteine-type peptidase activity; cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; proteolysis; regulation of translational initiation; translation initiation factor activity IPR027531; IPR000555; IPR024969; Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC 3.4.19.12) (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47) EIF3F EIF3S5 Homo sapiens (Human) TR22665_c0_g1_i2 Q8BRH4 MLL3_MOUSE 8.00E-20 GO:0003677; GO:0042800; GO:0035097; GO:0035556; GO:0006355; GO:0006351; GO:0008270 "DNA binding; histone methyltransferase activity (H3-K4 specific); histone methyltransferase complex; intracellular signal transduction; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR017956; IPR003889; IPR003888; IPR009071; IPR000637; IPR003616; IPR002219; IPR001214; IPR001594; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.43) (Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog) Kmt2c Mll3 Mus musculus (Mouse) TR22669_c0_g1_i1 Q96C10 DHX58_HUMAN 4.00E-13 GO:0005524; GO:0003677; GO:0005737; GO:0051607; GO:0003725; GO:0004386; GO:0045087; GO:0019048; GO:0039534; GO:0039536; GO:0045824; GO:0032480; GO:1900245; GO:1900246; GO:0032481; GO:0009615; GO:0003727; GO:0008270 Q9UKV8; Q7L2E3; Q9UPY3; P19525; P56537; O15226; P11207; P30927; Q9EMA9; Q9NUL3 ATP binding; DNA binding; cytoplasm; defense response to virus; double-stranded RNA binding; helicase activity; innate immune response; modulation by virus of host morphology or physiology; negative regulation of MDA-5 signaling pathway; negative regulation of RIG-I signaling pathway; negative regulation of innate immune response; negative regulation of type I interferon production; positive regulation of MDA-5 signaling pathway; positive regulation of RIG-I signaling pathway; positive regulation of type I interferon production; response to virus; single-stranded RNA binding; zinc ion binding IPR006935; IPR014001; IPR001650; IPR027417; IPR021673; Probable ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (Probable ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR) DHX58 D11LGP2E LGP2 Homo sapiens (Human) TR22672_c0_g1_i1 Q9CZH3 PSMG3_MOUSE 1.00E-17 IPR018788; Proteasome assembly chaperone 3 (PAC-3) (mPAC3) Psmg3 Pac3 Mus musculus (Mouse) TR22676_c0_g2_i1 Q9VZ08 RME6_DROME 6.00E-13 GO:0032794; GO:0005096; GO:0005829; GO:0006897; GO:0005085; GO:0016020; GO:0043547; GO:0051223; GO:0051056; GO:0007165 GTPase activating protein binding; GTPase activator activity; cytosol; endocytosis; guanyl-nucleotide exchange factor activity; membrane; positive regulation of GTPase activity; regulation of protein transport; regulation of small GTPase mediated signal transduction; signal transduction IPR024767; IPR001936; IPR008936; IPR003123; IPR013995; Receptor-mediated endocytosis protein 6 homolog CG1657 Drosophila melanogaster (Fruit fly) TR22676_c2_g1_i1 A2RV61 GAPD1_XENLA 3.00E-31 GO:0032794; GO:0005096; GO:0005829; GO:0006897; GO:0005768; GO:0005085; GO:0016020; GO:0043547; GO:0051223; GO:0051056; GO:0007165 GTPase activating protein binding; GTPase activator activity; cytosol; endocytosis; endosome; guanyl-nucleotide exchange factor activity; membrane; positive regulation of GTPase activity; regulation of protein transport; regulation of small GTPase mediated signal transduction; signal transduction IPR001936; IPR008936; IPR003123; IPR013995; GTPase-activating protein and VPS9 domain-containing protein 1 gapvd1 Xenopus laevis (African clawed frog) TR22682_c0_g1_i1 Q0P4I1 CEP44_XENTR 2.00E-26 GO:0005813; GO:0005737; GO:0030496; GO:0000922 centrosome; cytoplasm; midbody; spindle pole Centrosomal protein of 44 kDa (Cep44) cep44 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR22683_c2_g1_i1 P50748 KNTC1_HUMAN 3.00E-22 GO:0051301; GO:0000777; GO:0005829; GO:0005828; GO:0007067; GO:0000278; GO:0007093; GO:0005634; GO:0006461; GO:0007096; GO:0000922 cell division; condensed chromosome kinetochore; cytosol; kinetochore microtubule; mitosis; mitotic cell cycle; mitotic cell cycle checkpoint; nucleus; protein complex assembly; regulation of exit from mitosis; spindle pole IPR019527; IPR017986; Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod) KNTC1 KIAA0166 Homo sapiens (Human) TR22689_c0_g1_i3 Q91ZW9 C209C_MOUSE 7.00E-07 GO:0005537; GO:0046872 mannose binding; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; CD209 antigen-like protein C (DC-SIGN-related protein 2) (DC-SIGNR2) (CD antigen CD209) Cd209c Mus musculus (Mouse) TR22691_c0_g1_i1 O88761 PSMD1_RAT 1.00E-14 GO:0030234; GO:0022624; GO:0050790; GO:0042176 enzyme regulator activity; proteasome accessory complex; regulation of catalytic activity; regulation of protein catabolic process IPR016642; IPR011989; IPR016024; IPR002015; 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112) Psmd1 Rattus norvegicus (Rat) TR22693_c1_g1_i1 Q5TZ24 MOXD1_DANRE 4.00E-29 GO:0006584; GO:0005507; GO:0004500; GO:0005789; GO:0016021 catecholamine metabolic process; copper ion binding; dopamine beta-monooxygenase activity; endoplasmic reticulum membrane; integral to membrane IPR014784; IPR000323; IPR000945; IPR005018; IPR008977; DBH-like monooxygenase protein 1 homolog (EC 1.14.17.-) moxd1 si:ch211-193l17.1 si:dkey-266k12.5 si:dkeyp-119b4.5 Danio rerio (Zebrafish) (Brachydanio rerio) TR22696_c0_g1_i1 Q9N294 B3GT5_PANPA 4.00E-14 GO:0000139; GO:0008378; GO:0016021; GO:0006486 Golgi membrane; galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5) (Fragment)" B3GALT5 Pan paniscus (Pygmy chimpanzee) (Bonobo) TR22697_c1_g1_i2 Q9DC26 S46A3_MOUSE 3.00E-08 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR016196; Solute carrier family 46 member 3 Slc46a3 Mus musculus (Mouse) TR22698_c0_g1_i1 Q9DA39 LFG4_MOUSE 2.00E-42 GO:0000139; GO:0005795; GO:0006915; GO:0016021; GO:0043066; GO:0050848 Golgi membrane; Golgi stack; apoptotic process; integral to membrane; negative regulation of apoptotic process; regulation of calcium-mediated signaling IPR006214; Protein lifeguard 4 (Transmembrane BAX inhibitor motif-containing protein 4) (Z-protein) Tmbim4 Lfg4 Mus musculus (Mouse) TR22699_c0_g1_i1 P21139 MA2C1_RAT 7.00E-20 GO:0004559; GO:0030246; GO:0005783; GO:0006013; GO:0008270 alpha-mannosidase activity; carbohydrate binding; endoplasmic reticulum; mannose metabolic process; zinc ion binding IPR011013; IPR011330; IPR027291; IPR011682; IPR015341; IPR000602; Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1) Man2c1 Rattus norvegicus (Rat) TR22701_c3_g1_i1 Q8BM75 ARI5B_MOUSE 1.00E-57 GO:0030325; GO:0048468; GO:0060325; GO:0045444; GO:0060613; GO:0008585; GO:0010761; GO:0001822; GO:0008584; GO:0035264; GO:0048644; GO:0006807; GO:0005634; GO:0060021; GO:0048008; GO:0051091; GO:0009791; GO:0048705; GO:0003713; GO:0044212; GO:0006351 "adrenal gland development; cell development; face morphogenesis; fat cell differentiation; fat pad development; female gonad development; fibroblast migration; kidney development; male gonad development; multicellular organism growth; muscle organ morphogenesis; nitrogen compound metabolic process; nucleus; palate development; platelet-derived growth factor receptor signaling pathway; positive regulation of sequence-specific DNA binding transcription factor activity; post-embryonic development; skeletal system morphogenesis; transcription coactivator activity; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR001606; AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (Developmentally and sexually retarded with transient immune abnormalities protein) (Desrt) (MRF1-like) (Modulator recognition factor protein 2) (MRF-2) Arid5b Desrt Mrf2 Mus musculus (Mouse) TR22701_c7_g1_i1 E7F888 ARI5B_DANRE 7.00E-33 GO:0060612; GO:0005634; GO:0051091; GO:0044212; GO:0006351 "adipose tissue development; nucleus; positive regulation of sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR001606; AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) arid5b Danio rerio (Zebrafish) (Brachydanio rerio) TR22704_c0_g1_i1 Q62193 RFA2_MOUSE 1.00E-47 GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0016605; GO:0005654; GO:0010569 DNA binding; DNA recombination; DNA repair; DNA replication; PML body; nucleoplasm; regulation of double-strand break repair via homologous recombination IPR012340; IPR014646; IPR014892; IPR011991; Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) Rpa2 Rpa34 Mus musculus (Mouse) TR22710_c2_g1_i1 Q7Z469 YK019_HUMAN 2.00E-12 GO:0016021; GO:0005743; GO:0006810 integral to membrane; mitochondrial inner membrane; transport IPR018108; IPR023395; Putative mitochondrial carrier protein LOC494141 Homo sapiens (Human) TR22710_c3_g1_i1 Q9H1U9 S2551_HUMAN 1.00E-38 GO:0016021; GO:0005743; GO:0006810 integral to membrane; mitochondrial inner membrane; transport IPR018108; IPR023395; Solute carrier family 25 member 51 (Mitochondrial carrier triple repeat protein 1) SLC25A51 MCART1 Homo sapiens (Human) TR22712_c1_g1_i1 Q6UPE0 CHDH_RAT 2.00E-25 GO:0008812; GO:0050660; GO:0019285; GO:0005743 choline dehydrogenase activity; flavin adenine dinucleotide binding; glycine betaine biosynthetic process from choline; mitochondrial inner membrane IPR012132; IPR000172; IPR007867; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. "Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)" Chdh Rattus norvegicus (Rat) TR22713_c0_g1_i1 P21369 PNCA_ECOLI 5.00E-11 GO:0008936; GO:0019363 nicotinamidase activity; pyridine nucleotide biosynthetic process IPR000868; Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1. Pyrazinamidase/nicotinamidase (PZAase) (EC 3.5.1.-) (EC 3.5.1.19) (Nicotine deamidase) (NAMase) pncA nam ydjB b1768 JW1757 Escherichia coli (strain K12) TR22713_c0_g2_i1 P21369 PNCA_ECOLI 5.00E-11 GO:0008936; GO:0019363 nicotinamidase activity; pyridine nucleotide biosynthetic process IPR000868; Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1. Pyrazinamidase/nicotinamidase (PZAase) (EC 3.5.1.-) (EC 3.5.1.19) (Nicotine deamidase) (NAMase) pncA nam ydjB b1768 JW1757 Escherichia coli (strain K12) TR22719_c0_g1_i1 O16797 RL3_DROME 0 GO:0051298; GO:0000022; GO:0005840; GO:0003735; GO:0006412 centrosome duplication; mitotic spindle elongation; ribosome; structural constituent of ribosome; translation IPR000597; IPR019926; IPR009000; 60S ribosomal protein L3 RpL3 CG4863 Drosophila melanogaster (Fruit fly) TR22719_c0_g1_i2 Q29293 RL3_PIG 9.00E-55 GO:0005730; GO:0005840; GO:0003735; GO:0006412 nucleolus; ribosome; structural constituent of ribosome; translation IPR000597; IPR019926; IPR009000; 60S ribosomal protein L3 (Fragment) RPL3 Sus scrofa (Pig) TR22723_c1_g1_i2 Q6UXB8 PI16_HUMAN 9.00E-06 GO:0005576; GO:0016021; GO:0030414 extracellular region; integral to membrane; peptidase inhibitor activity IPR001283; IPR018244; IPR014044; Peptidase inhibitor 16 (PI-16) (Cysteine-rich secretory protein 9) (CRISP-9) (PSP94-binding protein) PI16 CRISP9 PSPBP PSEC0164 UNQ289/PRO328 Homo sapiens (Human) TR22725_c0_g1_i1 P01267 THYG_BOVIN 2.00E-07 GO:0005615; GO:0042446; GO:0006590 extracellular space; hormone biosynthetic process; thyroid hormone generation IPR002018; IPR019819; IPR009030; IPR016324; IPR000716; IPR011641; Thyroglobulin (Tg) TG Bos taurus (Bovine) TR22725_c1_g1_i1 P10079 FBP1_STRPU 2.00E-15 GO:0032579; GO:0005509; GO:0016023; GO:0005615 apical lamina of hyaline layer; calcium ion binding; cytoplasmic membrane-bounded vesicle; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) TR22726_c0_g2_i1 Q7T312 CCD25_DANRE 2.00E-65 IPR008532; Coiled-coil domain-containing protein 25 ccdc25 zgc:64173 Danio rerio (Zebrafish) (Brachydanio rerio) TR22728_c1_g1_i1 A6QP05 DHR12_BOVIN 3.00E-53 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; Dehydrogenase/reductase SDR family member 12 (EC 1.1.-.-) DHRS12 Bos taurus (Bovine) TR22728_c2_g2_i1 Q8TC12 RDH11_HUMAN 2.00E-21 GO:0052650; GO:0005789; GO:0016021; GO:0007603; GO:0042574; GO:0004745 "NADP-retinol dehydrogenase activity; endoplasmic reticulum membrane; integral to membrane; phototransduction, visible light; retinal metabolic process; retinol dehydrogenase activity" IPR002198; IPR002347; IPR016040; Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) RDH11 ARSDR1 PSDR1 CGI-82 Homo sapiens (Human) TR22731_c0_g1_i1 Q90YT1 RL37_ICTPU 1.00E-30 GO:0046872; GO:0019843; GO:0005840; GO:0003735; GO:0006412 metal ion binding; rRNA binding; ribosome; structural constituent of ribosome; translation IPR011331; IPR001569; IPR018267; IPR011332; 60S ribosomal protein L37 rpl37 Ictalurus punctatus (Channel catfish) (Silurus punctatus) TR22735_c0_g1_i1 Q8VCD6 REEP2_MOUSE 6.00E-60 GO:0005881; GO:0005887; GO:0032596; GO:0050913; GO:0050916 cytoplasmic microtubule; integral to plasma membrane; protein transport into membrane raft; sensory perception of bitter taste; sensory perception of sweet taste IPR004345; Receptor expression-enhancing protein 2 Reep2 Mus musculus (Mouse) TR22736_c0_g1_i1 P17047 LAMP2_MOUSE 8.00E-08 GO:0016021; GO:0031902; GO:0005765; GO:0030670; GO:0005886 integral to membrane; late endosome membrane; lysosomal membrane; phagocytic vesicle membrane; plasma membrane IPR018134; IPR002000; Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (Lysosomal membrane glycoprotein type B) (LGP-B) (CD antigen CD107b) Lamp2 Lamp-2 Mus musculus (Mouse) TR22736_c0_g1_i2 P05300 LAMP1_CHICK 1.00E-23 GO:0010008; GO:0016021; GO:0005765; GO:0005886 endosome membrane; integral to membrane; lysosomal membrane; plasma membrane IPR018134; IPR002000; Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (Lysosome membrane glycoprotein LEP100) LAMP1 Gallus gallus (Chicken) TR22737_c2_g1_i1 P53624 MA121_DROME 9.00E-26 GO:0000139; GO:0005509; GO:0008340; GO:0035010; GO:0016021; GO:0004571; GO:0006486; GO:0072347 Q9VPM5; Q9V9Q6 "Golgi membrane; calcium ion binding; determination of adult lifespan; encapsulation of foreign target; integral to membrane; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; protein glycosylation; response to anesthetic" IPR001382; Protein modification; protein glycosylation. "Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Mannosidase-1)" alpha-Man-I ALPHA-MAN-1 mas-1 CG32684 Drosophila melanogaster (Fruit fly) TR22737_c6_g1_i1 P45701 MA1A1_RABIT 7.00E-158 GO:0000139; GO:0005509; GO:0005793; GO:0016021; GO:0004571; GO:0006486 "Golgi membrane; calcium ion binding; endoplasmic reticulum-Golgi intermediate compartment; integral to membrane; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; protein glycosylation" IPR001382; Protein modification; protein glycosylation. "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Mannosidase alpha class 1A member 1) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Fragment)" MAN1A1 Oryctolagus cuniculus (Rabbit) TR22740_c0_g1_i1 P38117 ETFB_HUMAN 5.00E-129 GO:0009055; GO:0005759; GO:0022904; GO:0044281 electron carrier activity; mitochondrial matrix; respiratory electron transport chain; small molecule metabolic process IPR000049; IPR014730; IPR012255; IPR014729; Electron transfer flavoprotein subunit beta (Beta-ETF) ETFB FP585 Homo sapiens (Human) TR22744_c0_g2_i1 Q8RWD9 ACBP5_ARATH 2.00E-06 GO:0005829; GO:0000062; GO:0008289; GO:0006869; GO:0009416 cytosol; fatty-acyl-CoA binding; lipid binding; lipid transport; response to light stimulus IPR000582; IPR014352; IPR015915; Acyl-CoA-binding domain-containing protein 5 (Acyl-CoA binding protein 5) ACBP5 At5g27630 F15A18.90 Arabidopsis thaliana (Mouse-ear cress) TR22744_c1_g1_i1 Q3USL1 KLDC9_MOUSE 7.00E-08 IPR011043; IPR015915; Kelch domain-containing protein 9 Klhdc9 Mus musculus (Mouse) TR22748_c2_g1_i1 Q8N184 ZN567_HUMAN 6.00E-12 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 567 ZNF567 Homo sapiens (Human) TR22748_c2_g1_i2 Q9ULD5 ZN777_HUMAN 3.00E-08 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR022137; IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 777 ZNF777 KIAA1285 Homo sapiens (Human) TR22752_c0_g1_i1 O88572 LRP6_MOUSE 1.00E-20 GO:0044332; GO:0021874; GO:0090244; GO:0042813; GO:0090245; GO:0046849; GO:0060444; GO:0061310; GO:0061324; GO:0005901; GO:0042074; GO:0009986; GO:0071397; GO:0021587; GO:0021795; GO:0060026; GO:0015026; GO:0071936; GO:0031410; GO:0071542; GO:0005769; GO:0048596; GO:0042733; GO:0035115; GO:0035116; GO:0009880; GO:0060059; GO:0005783; GO:0035261; GO:0060325; GO:0021861; GO:0021943; GO:0001947; GO:0016021; GO:0019210; GO:0005041; GO:0060596; GO:0030901; GO:0030917; GO:0050680; GO:0045599; GO:2000151; GO:2000162; GO:2000168; GO:2000164; GO:2000166; GO:2000149; GO:0071901; GO:0034392; GO:0014029; GO:0001843; GO:0043025; GO:0042475; GO:0060021; GO:0003344; GO:2000055; GO:0043065; GO:0045780; GO:0090263; GO:0045787; GO:0002053; GO:0045778; GO:0051091; GO:0045944; GO:0036342; GO:0090009; GO:0043235; GO:0090118; GO:0060284; GO:0051593; GO:0048705; GO:0045202; GO:0007268; GO:0021794; GO:0019534; GO:0060535 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt receptor signaling pathway involved in forebrain neuroblast division; Wnt receptor signaling pathway involved in somitogenesis; Wnt-activated receptor activity; axis elongation involved in somitogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development; canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; caveola; cell migration involved in gastrulation; cell surface; cellular response to cholesterol; cerebellum morphogenesis; cerebral cortex cell migration; convergent extension; coreceptor activity; coreceptor activity involved in Wnt receptor signaling pathway; cytoplasmic vesicle; dopaminergic neuron differentiation; early endosome; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic pattern specification; embryonic retina morphogenesis in camera-type eye; endoplasmic reticulum; external genitalia morphogenesis; face morphogenesis; forebrain radial glial cell differentiation; formation of radial glial scaffolds; heart looping; integral to membrane; kinase inhibitor activity; low-density lipoprotein receptor activity; mammary placode formation; midbrain development; midbrain-hindbrain boundary development; negative regulation of epithelial cell proliferation; negative regulation of fat cell differentiation; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis; negative regulation of planar cell polarity pathway involved in neural tube closure; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest formation; neural tube closure; neuronal cell body; odontogenesis of dentin-containing tooth; palate development; pericardium morphogenesis; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell cycle; positive regulation of mesenchymal cell proliferation; positive regulation of ossification; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; post-anal tail morphogenesis; primitive streak formation; receptor complex; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport; regulation of cell development; response to folic acid; skeletal system morphogenesis; synapse; synaptic transmission; thalamus development; toxin transporter activity; trachea cartilage morphogenesis IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 6 (LRP-6) Lrp6 Mus musculus (Mouse) TR22754_c0_g1_i1 O14514 BAI1_HUMAN 1.00E-22 GO:0004930; GO:0007409; GO:0007155; GO:0005911; GO:0005887; GO:0016525; GO:0008285; GO:0007218; GO:0007422 G-protein coupled receptor activity; axonogenesis; cell adhesion; cell-cell junction; integral to plasma membrane; negative regulation of angiogenesis; negative regulation of cell proliferation; neuropeptide signaling pathway; peripheral nervous system development IPR022624; IPR017981; IPR008077; IPR001879; IPR000832; IPR000203; IPR000884; Brain-specific angiogenesis inhibitor 1 BAI1 Homo sapiens (Human) TR22756_c0_g1_i1 Q32L92 CNN3_BOVIN 3.00E-37 GO:0003779; GO:0031032; GO:0008017 actin binding; actomyosin structure organization; microtubule binding IPR001997; IPR000557; IPR001715; IPR003096; "Calponin-3 (Calponin, acidic isoform)" CNN3 Bos taurus (Bovine) TR22757_c4_g1_i1 E6ZHJ8 FXL15_DICLA 8.00E-06 GO:0000086; GO:0019005; GO:0031146; GO:0030282; GO:0005737; GO:0009953; GO:0030513; GO:0016567 G2/M transition of mitotic cell cycle; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; bone mineralization; cytoplasm; dorsal/ventral pattern formation; positive regulation of BMP signaling pathway; protein ubiquitination IPR001810; Protein modification; protein ubiquitination. F-box/LRR-repeat protein 15 fbxl15 DLA_Ib03740 DLA_Ib03750 Dicentrarchus labrax (European seabass) (Morone labrax) TR22757_c5_g1_i1 Q9UKA2 FBXL4_HUMAN 9.00E-43 GO:0005737; GO:0005634; GO:0000151; GO:0006511 cytoplasm; nucleus; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process IPR001810; IPR006553; F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) (F-box protein FBL4/FBL5) FBXL4 FBL4 FBL5 Homo sapiens (Human) TR22760_c0_g1_i1 Q9V9J3 SRC42_DROME 6.00E-32 GO:0005524; GO:0007254; GO:0051017; GO:0005912; GO:0034332; GO:0043277; GO:0048749; GO:0007395; GO:0090136; GO:0046529; GO:0007476; GO:0042059; GO:0045886; GO:0004715; GO:0007424; GO:0004713; GO:0007435; GO:0007169; GO:0006099 "ATP binding; JNK cascade; actin filament bundle assembly; adherens junction; adherens junction organization; apoptotic cell clearance; compound eye development; dorsal closure, spreading of leading edge cells; epithelial cell-cell adhesion; imaginal disc fusion, thorax closure; imaginal disc-derived wing morphogenesis; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of synaptic growth at neuromuscular junction; non-membrane spanning protein tyrosine kinase activity; open tracheal system development; protein tyrosine kinase activity; salivary gland morphogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; tricarboxylic acid cycle" IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Tyrosine-protein kinase Src41) (Dsrc41) Src42A Src41 TK5 CG44128 Drosophila melanogaster (Fruit fly) TR22763_c0_g1_i3 Q63HN8 RN213_HUMAN 1.00E-17 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR018957; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) TR22764_c0_g1_i1 Q54H45 DRKB_DICDI 3.00E-39 GO:0005524; GO:0016021; GO:0004674 ATP binding; integral to membrane; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR001245; IPR008271; Probable serine/threonine-protein kinase drkB (EC 2.7.11.1) (Receptor-like kinase 2) (Receptor-like kinase B) (Vesicle-associated receptor tyrosine kinase-like protein 2) drkB rk2 DDB_G0289709 Dictyostelium discoideum (Slime mold) TR22767_c0_g1_i1 P05934 CALM_STRPU 4.00E-11 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) (Fragment) Strongylocentrotus purpuratus (Purple sea urchin) TR22767_c0_g1_i2 A3E4D8 CALM_PROMN 1.00E-29 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Prorocentrum minimum (Dinoflagellate) TR22768_c0_g1_i1 Q2PC93 SSPO_CHICK 6.00E-16 GO:0007155; GO:0005615 cell adhesion; extracellular space IPR000421; IPR006207; IPR008979; IPR023415; IPR002172; IPR000884; IPR002919; IPR014853; IPR001007; IPR001846; SCO-spondin SSPO Gallus gallus (Chicken) TR22769_c1_g1_i1 P38135 FADK_ECOLI 6.00E-25 GO:0005524; GO:0019395; GO:0016020; GO:0031955 ATP binding; fatty acid oxidation; membrane; short-chain fatty acid-CoA ligase activity IPR025110; IPR020845; IPR000873; Short-chain-fatty-acid--CoA ligase (EC 6.2.1.-) (Acyl-CoA synthetase) fadK ydiD b1701 JW5910 Escherichia coli (strain K12) TR22774_c0_g1_i2 Q9R0M5 TPK1_MOUSE 3.00E-73 GO:0005524; GO:0016301; GO:0009229; GO:0004788; GO:0006772 ATP binding; kinase activity; thiamine diphosphate biosynthetic process; thiamine diphosphokinase activity; thiamine metabolic process IPR006282; IPR016966; IPR007373; IPR007371; Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1. Thiamin pyrophosphokinase 1 (mTPK1) (EC 2.7.6.2) (Thiamine pyrophosphokinase 1) Tpk1 Mus musculus (Mouse) TR22775_c1_g2_i1 O00300 TR11B_HUMAN 2.00E-07 GO:0006915; GO:0005125; GO:0030198; GO:0005615; GO:0045779; GO:0042489; GO:0005578; GO:0004872; GO:0046685; GO:0042493; GO:0043627; GO:0032026; GO:0007584; GO:0007165; GO:0001501 apoptotic process; cytokine activity; extracellular matrix organization; extracellular space; negative regulation of bone resorption; negative regulation of odontogenesis of dentin-containing tooth; proteinaceous extracellular matrix; receptor activity; response to arsenic-containing substance; response to drug; response to estrogen stimulus; response to magnesium ion; response to nutrient; signal transduction; skeletal system development IPR011029; IPR000488; IPR001368; IPR022323; IPR017371; Tumor necrosis factor receptor superfamily member 11B (Osteoclastogenesis inhibitory factor) (Osteoprotegerin) TNFRSF11B OCIF OPG Homo sapiens (Human) TR22778_c0_g2_i1 P70665 SIAE_MOUSE 5.00E-19 GO:0004091; GO:0005764; GO:0001681 carboxylesterase activity; lysosome; sialate O-acetylesterase activity IPR005181; Sialate O-acetylesterase (EC 3.1.1.53) (Sialic acid-specific 9-O-acetylesterase) (Yolk sac protein 2) [Cleaved into: Sialate O-acetylesterase small subunit; Sialate O-acetylesterase large subunit] Siae Ysg2 Mus musculus (Mouse) TR22778_c3_g1_i1 Q9HAT2 SIAE_HUMAN 1.00E-47 GO:0004091; GO:0005576; GO:0005764; GO:0001681 carboxylesterase activity; extracellular region; lysosome; sialate O-acetylesterase activity IPR005181; Sialate O-acetylesterase (EC 3.1.1.53) (H-Lse) (Sialic acid-specific 9-O-acetylesterase) SIAE YSG2 Homo sapiens (Human) TR22780_c0_g1_i1 Q3MHL8 SMAP_BOVIN 9.00E-16 IPR026714; IPR028124; Small acidic protein SMAP Bos taurus (Bovine) TR22784_c0_g2_i1 Q58E76 ATD3A_XENLA 2.00E-132 GO:0005524; GO:0016021; GO:0005743; GO:0042645; GO:0017111 ATP binding; integral to membrane; mitochondrial inner membrane; mitochondrial nucleoid; nucleoside-triphosphatase activity IPR003593; IPR003959; IPR021911; IPR027417; ATPase family AAA domain-containing protein 3-A atad3-a Xenopus laevis (African clawed frog) TR22785_c1_g1_i1 A2RTY3 CQ066_HUMAN 4.00E-11 IPR011989; IPR016024; Uncharacterized protein C17orf66 C17orf66 Homo sapiens (Human) TR22788_c4_g1_i2 Q9NUV9 GIMA4_HUMAN 5.00E-25 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR22788_c5_g1_i1 Q96F15 GIMA5_HUMAN 5.00E-13 GO:0005525; GO:0030217; GO:0043029; GO:0016021; GO:0005764; GO:0005741; GO:0043011; GO:0050868; GO:0043066; GO:0032689; GO:0050995; GO:0045019; GO:0032831; GO:0010524; GO:0045588; GO:0002925; GO:0045838; GO:0002729; GO:0045954; GO:0046902; GO:0001659 "GTP binding; T cell differentiation; T cell homeostasis; integral to membrane; lysosome; mitochondrial outer membrane; myeloid dendritic cell differentiation; negative regulation of T cell activation; negative regulation of apoptotic process; negative regulation of interferon-gamma production; negative regulation of lipid catabolic process; negative regulation of nitric oxide biosynthetic process; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of calcium ion transport into cytosol; positive regulation of gamma-delta T cell differentiation; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of membrane potential; positive regulation of natural killer cell cytokine production; positive regulation of natural killer cell mediated cytotoxicity; regulation of mitochondrial membrane permeability; temperature homeostasis" IPR006703; IPR027417; GTPase IMAP family member 5 (Immunity-associated nucleotide 4-like 1 protein) (Immunity-associated nucleotide 5 protein) (IAN-5) (hIAN5) (Immunity-associated protein 3) GIMAP5 IAN4L1 IAN5 IMAP3 Homo sapiens (Human) TR22789_c2_g1_i1 O97725 NDUAC_BOVIN 3.00E-26 GO:0008137; GO:0009055; GO:0005747; GO:0006979 NADH dehydrogenase (ubiquinone) activity; electron carrier activity; mitochondrial respiratory chain complex I; response to oxidative stress IPR007763; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (Complex I-B17.2) (CI-B17.2) (CIB17.2) (NADH-ubiquinone oxidoreductase subunit B17.2) NDUFA12 Bos taurus (Bovine) TR22789_c2_g3_i1 Q9N2W7 NDUAC_CAEEL 1.00E-25 GO:0008137; GO:0009055; GO:0005743; GO:0005739; GO:0070469 NADH dehydrogenase (ubiquinone) activity; electron carrier activity; mitochondrial inner membrane; mitochondrion; respiratory chain IPR007763; Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (NADH-ubiquinone oxidoreductase 17.0 kDa subunit) Y94H6A.8 Caenorhabditis elegans TR2279_c0_g1_i1 Q7LHG5 YI31B_YEAST 4.00E-08 GO:0005524; GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0005737; GO:0008233; GO:0006508; GO:0000943; GO:0004523; GO:0004540; GO:0032197; GO:0046797; GO:0008270 "ATP binding; DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; cytoplasm; peptidase activity; proteolysis; retrotransposon nucleocapsid; ribonuclease H activity; ribonuclease activity; transposition, RNA-mediated; viral procapsid maturation; zinc ion binding" IPR001584; IPR024650; IPR021109; IPR005162; IPR012337; IPR000477; IPR001878; Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR22795_c0_g1_i1 Q92482 AQP3_HUMAN 2.00E-22 GO:0016323; GO:0005911; GO:0005737; GO:0007588; GO:0015254; GO:0016021; GO:0042476; GO:0005886; GO:0002684; GO:0045616; GO:0070295; GO:0051592; GO:0032526; GO:0033280; GO:0015840; GO:0015250 basolateral plasma membrane; cell-cell junction; cytoplasm; excretion; glycerol channel activity; integral to membrane; odontogenesis; plasma membrane; positive regulation of immune system process; regulation of keratinocyte differentiation; renal water absorption; response to calcium ion; response to retinoic acid; response to vitamin D; urea transport; water channel activity IPR023271; IPR023275; IPR000425; IPR022357; Aquaporin-3 (AQP-3) (Aquaglyceroporin-3) AQP3 Homo sapiens (Human) TR22796_c0_g1_i1 O34313 NTPES_BACSU 3.00E-10 GO:0008663; GO:0008254; GO:0008253; GO:0005618; GO:0005576; GO:0046872; GO:0000166; GO:0009166 "2',3'-cyclic-nucleotide 2'-phosphodiesterase activity; 3'-nucleotidase activity; 5'-nucleotidase activity; cell wall; extracellular region; metal ion binding; nucleotide binding; nucleotide catabolic process" IPR008334; IPR006146; IPR006179; IPR019931; IPR004843; "Trifunctional nucleotide phosphoesterase protein YfkN [Includes: 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase (EC 3.1.3.6) (EC 3.1.4.16); 5'-nucleotidase (EC 3.1.3.5)]" yfkN BSU07840 Bacillus subtilis (strain 168) TR22797_c2_g1_i1 Q40082 XYLA_HORVU 6.00E-36 GO:0042732; GO:0046872; GO:0006098; GO:0009045 D-xylose metabolic process; metal ion binding; pentose-phosphate shunt; xylose isomerase activity IPR013022; IPR013452; IPR001998; Xylose isomerase (EC 5.3.1.5) XYLA Hordeum vulgare (Barley) TR228_c0_g1_i1 Q4V8C9 LRC56_RAT 3.00E-14 IPR001611; IPR025875; IPR003603; Leucine-rich repeat-containing protein 56 Lrrc56 Rattus norvegicus (Rat) TR2280_c0_g1_i1 P21328 RTJK_DROME 2.00E-10 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) TR22802_c0_g1_i1 Q8BJ64 CHDH_MOUSE 0 GO:0008812; GO:0050660; GO:0019285; GO:0005743 choline dehydrogenase activity; flavin adenine dinucleotide binding; glycine betaine biosynthetic process from choline; mitochondrial inner membrane IPR011533; IPR012132; IPR000172; IPR007867; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. "Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)" Chdh Mus musculus (Mouse) TR22805_c2_g1_i1 Q5T655 CC147_HUMAN 4.00E-32 Coiled-coil domain-containing protein 147 CCDC147 C10orf80 Homo sapiens (Human) TR22808_c0_g1_i1 Q7ZV80 SPF30_DANRE 2.00E-53 GO:0015030; GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0016607; GO:0005681 Cajal body; RNA binding; RNA splicing; cytoplasm; mRNA processing; nuclear speck; spliceosomal complex IPR010304; IPR002999; Survival of motor neuron-related-splicing factor 30 (Survival motor neuron domain-containing protein 1) smndc1 spf30 Danio rerio (Zebrafish) (Brachydanio rerio) TR2281_c0_g1_i1 Q9P2K9 PTHD2_HUMAN 3.00E-07 GO:0042632; GO:0005783; GO:0008158; GO:0016021; GO:0031965; GO:0032368; GO:0007224 cholesterol homeostasis; endoplasmic reticulum; hedgehog receptor activity; integral to membrane; nuclear membrane; regulation of lipid transport; smoothened signaling pathway IPR004869; IPR003392; IPR000731; Patched domain-containing protein 2 (Protein dispatched homolog 3) PTCHD2 DISP3 KIAA1337 Homo sapiens (Human) TR22811_c0_g1_i1 A1YG61 EHF_PANPA 2.00E-22 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; ETS homologous factor (ETS domain-containing transcription factor) EHF Pan paniscus (Pygmy chimpanzee) (Bonobo) TR22812_c1_g1_i1 Q80VG1 SCML4_MOUSE 3.00E-16 GO:0003677; GO:0005634; GO:0006355; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR017956; IPR021987; IPR001660; IPR013761; IPR021129; Sex comb on midleg-like protein 4 Scml4 Mus musculus (Mouse) TR22812_c2_g1_i1 B2D6M2 LIN61_CAEEL 1.00E-18 GO:0000785; GO:0005634; GO:0006355; GO:0040025 "chromatin; nucleus; regulation of transcription, DNA-dependent; vulval development" IPR004092; Protein lin-61 (Abnormal cell lineage protein 61) lin-61 R06C7.7 Caenorhabditis elegans TR22812_c3_g1_i2 Q9VHA0 SCM_DROME 1.00E-52 GO:0035102; GO:0007409; GO:0016568; GO:0016458; GO:0030708; GO:0045892; GO:0030713; GO:0005700; GO:0006351; GO:0008270 Itself; P41046; P02299; P39769 "PRC1 complex; axonogenesis; chromatin modification; gene silencing; germarium-derived female germ-line cyst encapsulation; negative regulation of transcription, DNA-dependent; ovarian follicle cell stalk formation; polytene chromosome; transcription, DNA-dependent; zinc ion binding" IPR021987; IPR004092; IPR001660; IPR013761; IPR021129; IPR012313; IPR010507; Polycomb protein Scm (Sex comb on midleg protein) Scm CG9495 Drosophila melanogaster (Fruit fly) TR22812_c3_g1_i3 Q8BLB7 LMBL3_MOUSE 1.00E-21 GO:0016568; GO:0005634; GO:0006355; GO:0006351 "chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR004092; IPR001660; IPR013761; IPR021129; Lethal(3)malignant brain tumor-like protein 3 (L(3)mbt-like protein 3) (MBT-1) L3mbtl3 Mbt1 Mus musculus (Mouse) TR22818_c1_g1_i1 Q96MM6 HS12B_HUMAN 3.00E-66 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR22818_c1_g1_i2 Q96MM6 HS12B_HUMAN 3.00E-65 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR22825_c0_g1_i1 Q15370 ELOB_HUMAN 2.00E-17 GO:0031462; GO:0031466; GO:0005829; GO:0005654; GO:0050434; GO:0006461; GO:0016567; GO:0061418; GO:0006368; GO:0031625; GO:0016032 Q96G25; Q15369; P12504 Cul2-RING ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex; cytosol; nucleoplasm; positive regulation of viral transcription; protein complex assembly; protein ubiquitination; regulation of transcription from RNA polymerase II promoter in response to hypoxia; transcription elongation from RNA polymerase II promoter; ubiquitin protein ligase binding; viral process IPR000626; Protein modification; protein ubiquitination. Transcription elongation factor B polypeptide 2 (Elongin 18 kDa subunit) (Elongin-B) (EloB) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) TCEB2 Homo sapiens (Human) TR22830_c0_g1_i1 Q9Y561 LRP12_HUMAN 2.00E-08 GO:0005905; GO:0005887; GO:0005041; GO:0040008; GO:0007165 P63244; Q9NPI5; O95405 coated pit; integral to plasma membrane; low-density lipoprotein receptor activity; regulation of growth; signal transduction IPR000859; IPR023415; IPR002172; Low-density lipoprotein receptor-related protein 12 (LRP-12) (Suppressor of tumorigenicity 7 protein) LRP12 ST7 Homo sapiens (Human) TR22830_c0_g1_i2 P98073 ENTK_HUMAN 4.00E-07 GO:0005903; GO:0016021; GO:0006508; GO:0005044; GO:0004252 brush border; integral to membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity IPR008985; IPR000859; IPR023415; IPR002172; IPR000998; IPR001254; IPR018114; IPR001314; IPR000082; IPR001190; IPR017448; IPR009003; Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain] TMPRSS15 ENTK PRSS7 Homo sapiens (Human) TR22832_c0_g1_i2 Q9NX78 CN101_HUMAN 2.00E-10 GO:0016021 integral to membrane IPR021280; Transmembrane protein 260 TMEM260 C14orf101 Homo sapiens (Human) TR22841_c2_g1_i1 Q9HCU4 CELR2_HUMAN 6.00E-07 GO:0004930; GO:0016055; GO:0005509; GO:0033326; GO:0042384; GO:0003341; GO:0005737; GO:0048813; GO:0007156; GO:0016021; GO:0021999; GO:0001764; GO:0007218; GO:0005886; GO:0022407; GO:0032880; GO:0006355; GO:0021591 "G-protein coupled receptor activity; Wnt receptor signaling pathway; calcium ion binding; cerebrospinal fluid secretion; cilium assembly; cilium movement; cytoplasm; dendrite morphogenesis; homophilic cell adhesion; integral to membrane; neural plate anterior/posterior regionalization; neuron migration; neuropeptide signaling pathway; plasma membrane; regulation of cell-cell adhesion; regulation of protein localization; regulation of transcription, DNA-dependent; ventricular system development" IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR001881; IPR013032; IPR000152; IPR002049; IPR017981; IPR001879; IPR000832; IPR000203; IPR009030; IPR001791; IPR001368; Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) CELSR2 CDHF10 EGFL2 KIAA0279 MEGF3 Homo sapiens (Human) TR22841_c2_g1_i2 O75095 MEGF6_HUMAN 7.00E-28 GO:0005509; GO:0005576 O15265; O00555 calcium ion binding; extracellular region IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR002049; IPR011489; IPR009030; Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) TR22844_c0_g1_i1 Q196X6 VF232_IIV3 7.00E-06 GO:0006353; GO:0008234; GO:0006508 "DNA-dependent transcription, termination; cysteine-type peptidase activity; proteolysis" IPR003323; IPR011112; Putative ubiquitin thioesterase 232R (EC 3.4.19.12) IIV3-084L Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus) TR22845_c1_g3_i1 Q5XIR4 CCD33_RAT 6.00E-11 IPR000008; Coiled-coil domain-containing protein 33 Ccdc33 Rattus norvegicus (Rat) TR22846_c0_g2_i1 Q9Y5W8 SNX13_HUMAN 9.00E-49 GO:0007154; GO:0005769; GO:0031901; GO:0006886; GO:0035091; GO:0043547; GO:0038032 cell communication; early endosome; early endosome membrane; intracellular protein transport; phosphatidylinositol binding; positive regulation of GTPase activity; termination of G-protein coupled receptor signaling pathway IPR001683; IPR003114; IPR013996; IPR016137; IPR000342; IPR013937; Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1) SNX13 KIAA0713 Homo sapiens (Human) TR22846_c2_g1_i1 Q75C43 SNX4_ASHGO 2.00E-10 GO:0006914; GO:0007154; GO:0010008; GO:0035091; GO:0015031 autophagy; cell communication; endosome membrane; phosphatidylinositol binding; protein transport IPR001683; Sorting nexin-4 (Autophagy-related protein 24) SNX4 ATG24 ACR074W Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR22849_c0_g1_i1 Q4PM54 RL17_IXOSC 3.00E-93 GO:0015934; GO:0003735; GO:0006412 large ribosomal subunit; structural constituent of ribosome; translation IPR001063; IPR018260; IPR005721; 60S ribosomal protein L17 RpL17 Ixodes scapularis (Black-legged tick) (Deer tick) TR22850_c0_g1_i1 P35125 UBP6_HUMAN 7.00E-35 GO:0005097; GO:0004197; GO:0005764; GO:0003676; GO:0005886; GO:0032851; GO:0016579; GO:0055037; GO:0060627; GO:0004221; GO:0006511; GO:0004843 Q8N8A2; P10916 Rab GTPase activator activity; cysteine-type endopeptidase activity; lysosome; nucleic acid binding; plasma membrane; positive regulation of Rab GTPase activity; protein deubiquitination; recycling endosome; regulation of vesicle-mediated transport; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR018200; IPR001394; IPR000195; Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) USP6 HRP1 TRE2 Homo sapiens (Human) TR22850_c2_g1_i1 Q8NFA0 UBP32_HUMAN 9.00E-34 GO:0005794; GO:0005509; GO:0008234; GO:0016020; GO:0016579; GO:0004221; GO:0006511 Golgi apparatus; calcium ion binding; cysteine-type peptidase activity; membrane; protein deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR011992; IPR018247; IPR002048; IPR006615; IPR018200; IPR001394; IPR001125; IPR028135; Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) USP32 USP10 Homo sapiens (Human) TR22852_c3_g1_i1 Q4R8T1 EFCB6_MACFA 8.00E-19 GO:0005509; GO:0005634; GO:0006355; GO:0006351 "calcium ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011992; IPR015070; IPR002048; EF-hand calcium-binding domain-containing protein 6 (DJ-1-binding protein) (DJBP) (Fragment) EFCAB6 DJBP QtsA-11542 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR22852_c3_g2_i1 Q9C8Y1 CML23_ARATH 7.00E-06 GO:0005509; GO:0009909; GO:0080164 calcium ion binding; regulation of flower development; regulation of nitric oxide metabolic process IPR011992; IPR018247; IPR002048; Probable calcium-binding protein CML23 (Calmodulin-like protein 23) CML23 At1g66400 T27F4.15 Arabidopsis thaliana (Mouse-ear cress) TR22856_c0_g1_i1 Q3ZBF8 CERS2_BOVIN 2.00E-15 GO:0005789; GO:0016021; GO:0006629; GO:0031965; GO:0043565; GO:0003700 endoplasmic reticulum membrane; integral to membrane; lipid metabolic process; nuclear membrane; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR001356; IPR009057; IPR016439; IPR006634; Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) CERS2 LASS2 Bos taurus (Bovine) TR22856_c1_g2_i1 Q8C172 CERS6_MOUSE 4.00E-34 GO:0046513; GO:0005783; GO:0005789; GO:0016021; GO:0031965; GO:0043565; GO:0003700; GO:0050291 ceramide biosynthetic process; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nuclear membrane; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sphingosine N-acyltransferase activity IPR001356; IPR009057; IPR016439; IPR006634; Ceramide synthase 6 (CerS6) (LAG1 longevity assurance homolog 6) Cers6 Lass6 Mus musculus (Mouse) TR22859_c0_g1_i1 Q9I927 FUCL5_ANGJA 4.00E-11 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-5 Anguilla japonica (Japanese eel) TR22860_c0_g1_i2 P80571 DEFI_MYTGA 2.00E-17 GO:0042742; GO:0005576; GO:0045087 defense response to bacterium; extracellular region; innate immune response IPR001542; IPR003614; Defensin MGD-1 (Fragment) FH3 Mytilus galloprovincialis (Mediterranean mussel) TR22861_c4_g1_i1 Q8TBP0 TBC16_HUMAN 3.00E-51 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; TBC1 domain family member 16 TBC1D16 Homo sapiens (Human) TR22863_c0_g1_i1 Q01406 SRC8_CHICK 4.00E-48 GO:0005856; GO:0043197; GO:0005783; GO:0030027; GO:0005886; GO:0001726 P39054; Q8AYS8 cytoskeleton; dendritic spine; endoplasmic reticulum; lamellipodium; plasma membrane; ruffle IPR015503; IPR003134; IPR000108; IPR001452; Src substrate protein p85 (Cortactin) (p80) CTTN1 EMS1 P85.25 Gallus gallus (Chicken) TR22870_c1_g1_i1 Q68D06 SLN13_HUMAN 3.00E-06 GO:0005524; GO:0005622 ATP binding; intracellular IPR007421; IPR018647; IPR027417; Schlafen family member 13 SLFN13 Homo sapiens (Human) TR22872_c0_g1_i1 Q9VS60 SMSR1_DROME 3.00E-81 GO:0007030; GO:0046513; GO:0047493; GO:0030176; GO:0060305; GO:2000303; GO:0006686; GO:0033188 Golgi organization; ceramide biosynthetic process; ceramide cholinephosphotransferase activity; integral to endoplasmic reticulum membrane; regulation of cell diameter; regulation of ceramide biosynthetic process; sphingomyelin biosynthetic process; sphingomyelin synthase activity IPR001660; IPR013761; IPR025749; Sphingomyelin synthase-related 1 (Ceramide phosphoethanolamine synthase) (CPE synthase) (EC 2.7.8.-) SMSr CG32380 Drosophila melanogaster (Fruit fly) TR22881_c1_g2_i1 Q6IMK3 DJC27_DANRE 3.00E-50 GO:0005525; GO:0007264 GTP binding; small GTPase mediated signal transduction IPR001623; IPR027417; IPR005225; IPR001806; DnaJ homolog subfamily C member 27 (Rab and DnaJ domain-containing protein) dnajc27 rbj Danio rerio (Zebrafish) (Brachydanio rerio) TR22883_c0_g1_i1 Q13263 TIF1B_HUMAN 3.00E-13 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR22886_c1_g2_i1 A3KG59 P20D2_MOUSE 3.00E-44 GO:0016787 hydrolase activity IPR017439; IPR017144; IPR011650; Peptidase M20 domain-containing protein 2 (Aminoacylase-1-like protein 2) Pm20d2 Acy1l2 Gm424 Mus musculus (Mouse) TR22890_c1_g1_i1 Q3ZBF0 NADE_BOVIN 4.00E-74 GO:0005524; GO:0009435; GO:0003952; GO:0016810 "ATP binding; NAD biosynthetic process; NAD+ synthase (glutamine-hydrolyzing) activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds" IPR003010; IPR014445; IPR022310; IPR003694; IPR014729; Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1. Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) (NAD(+) synthetase) NADSYN1 Bos taurus (Bovine) TR22901_c1_g2_i1 Q8N3J2 METL4_HUMAN 4.00E-15 GO:0008168; GO:0003676; GO:0006139 methyltransferase activity; nucleic acid binding; nucleobase-containing compound metabolic process IPR002052; IPR007757; Methyltransferase-like protein 4 (EC 2.1.1.-) METTL4 Homo sapiens (Human) TR22909_c0_g1_i1 Q5UPX1 YL289_MIMIV 4.00E-06 IPR002110; IPR020683; Putative ankyrin repeat protein L289 MIMI_L289 Acanthamoeba polyphaga mimivirus (APMV) TR22910_c0_g1_i1 Q11118 WOS2_SCHPO 4.00E-22 GO:0007049; GO:0051087; GO:0005829; GO:0005634; GO:0032212; GO:0006457; GO:0007346 cell cycle; chaperone binding; cytosol; nucleus; positive regulation of telomere maintenance via telomerase; protein folding; regulation of mitotic cell cycle IPR007052; IPR008978; Protein wos2 (p21) wos2 SPAC9E9.13 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR22914_c1_g1_i1 P24014 SLIT_DROME 8.00E-10 GO:0035385; GO:0071666; GO:0016199; GO:0005509; GO:0048813; GO:0007502; GO:0035050; GO:0007427; GO:0008347; GO:0008406; GO:0008201; GO:0050929; GO:0046331; GO:0008078; GO:0001764; GO:0003151; GO:0005886; GO:0022409; GO:0005578; GO:2000274; GO:0007432 "Roundabout signaling pathway; Slit-Robo signaling complex; axon midline choice point recognition; calcium ion binding; dendrite morphogenesis; digestive tract mesoderm development; embryonic heart tube development; epithelial cell migration, open tracheal system; glial cell migration; gonad development; heparin binding; induction of negative chemotaxis; lateral inhibition; mesodermal cell migration; neuron migration; outflow tract morphogenesis; plasma membrane; positive regulation of cell-cell adhesion; proteinaceous extracellular matrix; regulation of epithelial cell migration, open tracheal system; salivary gland boundary specification" IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; IPR026906; Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) TR22914_c3_g1_i1 Q91W20 LRC26_MOUSE 2.00E-08 GO:0005737; GO:0005856; GO:0006811; GO:0015459; GO:0008076 cytoplasm; cytoskeleton; ion transport; potassium channel regulator activity; voltage-gated potassium channel complex IPR000483; IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing protein 26 (BK channel auxiliary gamma subunit LRRC26) Lrrc26 Mus musculus (Mouse) TR22914_c4_g1_i1 Q9WV82 TLR4_CRIGR 8.00E-09 GO:0002755; GO:0050829; GO:0032497; GO:0006954; GO:0045087; GO:0001875; GO:0046696; GO:0042116; GO:0050707; GO:0034142; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-negative bacterium; detection of lipopolysaccharide; inflammatory response; innate immune response; lipopolysaccharide receptor activity; lipopolysaccharide receptor complex; macrophage activation; regulation of cytokine secretion; toll-like receptor 4 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR025875; IPR003591; IPR000157; IPR027168; IPR017241; Toll-like receptor 4 (CD antigen CD284) TLR4 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR22915_c1_g1_i1 P07746 HMGT_ONCMY 2.00E-20 GO:0003677; GO:0005694; GO:0005634 DNA binding; chromosome; nucleus IPR009071; IPR017967; High mobility group-T protein (HMG-T) (HMG-T1) (HMG-1) Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR22920_c0_g1_i1 Q9NQV6 PRD10_HUMAN 2.00E-17 GO:0003677; GO:0046872; GO:0008168; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; methyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; IPR022755; PR domain zinc finger protein 10 (EC 2.1.1.-) (PR domain-containing protein 10) (Tristanin) PRDM10 KIAA1231 PFM7 TRIS Homo sapiens (Human) TR22921_c1_g1_i1 A2ASS6 TITIN_MOUSE 4.00E-06 GO:0005524; GO:0031430; GO:0030018; GO:0007512; GO:0055003; GO:0043056; GO:0003007; GO:0001701; GO:0046872; GO:0006936; GO:0005859; GO:0005634; GO:0018108; GO:0004674; GO:0004713; GO:1901897; GO:0045214; GO:0001756; GO:0005200 ATP binding; M band; Z disc; adult heart development; cardiac myofibril assembly; forward locomotion; heart morphogenesis; in utero embryonic development; metal ion binding; muscle contraction; muscle myosin complex; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of relaxation of cardiac muscle; sarcomere organization; somitogenesis; structural constituent of cytoskeleton IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) TR22927_c0_g1_i1 Q9QZS7 NPHN_MOUSE 2.00E-06 GO:0007254; GO:0007155; GO:0042995; GO:0032836; GO:0072015; GO:0005887; GO:0007520; GO:0030838; GO:0044062; GO:0007519; GO:0036057 JNK cascade; cell adhesion; cell projection; glomerular basement membrane development; glomerular visceral epithelial cell development; integral to plasma membrane; myoblast fusion; positive regulation of actin filament polymerization; regulation of excretion; skeletal muscle tissue development; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Mus musculus (Mouse) TR22928_c1_g1_i1 P17132 HNRPC_RAT 3.00E-06 GO:0003723; GO:0008380; GO:0006397; GO:0000166; GO:0005681 RNA binding; RNA splicing; mRNA processing; nucleotide binding; spliceosomal complex IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein C (hnRNP C) (hnRNP core protein C) (Fragment) Hnrnpc Hnrpc Rattus norvegicus (Rat) TR22928_c3_g1_i1 P21522 ROA1_SCHAM 1.00E-33 GO:0003723; GO:0000166; GO:0005634; GO:0030529 RNA binding; nucleotide binding; nucleus; ribonucleoprotein complex IPR012677; IPR000504; "Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog" HNRNP Schistocerca americana (American grasshopper) TR22929_c0_g1_i1 Q6TLH3 CUED2_DANRE 7.00E-19 GO:0005737; GO:0005634 cytoplasm; nucleus CUE domain-containing protein 2 cuedc2 zgc:92255 Danio rerio (Zebrafish) (Brachydanio rerio) TR22937_c1_g1_i1 P80025 PERL_BOVIN 1.00E-36 GO:0042742; GO:0005615; GO:0020037; GO:0042744; GO:0046872; GO:0004601 defense response to bacterium; extracellular space; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity IPR010255; IPR002007; IPR019791; Lactoperoxidase (LPO) (EC 1.11.1.7) LPO Bos taurus (Bovine) TR22937_c1_g1_i2 P80025 PERL_BOVIN 1.00E-33 GO:0042742; GO:0005615; GO:0020037; GO:0042744; GO:0046872; GO:0004601 defense response to bacterium; extracellular space; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity IPR010255; IPR002007; IPR019791; Lactoperoxidase (LPO) (EC 1.11.1.7) LPO Bos taurus (Bovine) TR22943_c3_g1_i1 P46023 GR101_LYMST 2.00E-22 GO:0016021; GO:0005886; GO:0016500 integral to membrane; plasma membrane; protein-hormone receptor activity IPR000276; IPR017452; IPR002131; IPR023415; IPR002172; IPR001611; IPR003591; IPR000372; G-protein coupled receptor GRL101 Lymnaea stagnalis (Great pond snail) TR22943_c5_g1_i1 P46023 GR101_LYMST 1.00E-30 GO:0016021; GO:0005886; GO:0016500 integral to membrane; plasma membrane; protein-hormone receptor activity IPR000276; IPR017452; IPR002131; IPR023415; IPR002172; IPR001611; IPR003591; IPR000372; G-protein coupled receptor GRL101 Lymnaea stagnalis (Great pond snail) TR22944_c0_g1_i1 Q9U639 HSP7D_MANSE 0 GO:0005524; GO:0005634; GO:0006950 ATP binding; nucleus; response to stress IPR018181; IPR013126; Heat shock 70 kDa protein cognate 4 (Hsc 70-4) Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) TR22945_c0_g1_i1 Q8CEI1 BOLA3_MOUSE 1.00E-27 GO:0005576 extracellular region IPR002634; BolA-like protein 3 Bola3 Mus musculus (Mouse) TR22949_c1_g1_i1 Q92851 CASPA_HUMAN 3.00E-10 GO:0097190; GO:0004197; GO:0005829; GO:0045087; GO:0005886; GO:0043123; GO:0006508; GO:0042981; GO:0097342 Q14790; O15519; O14730; Q13546 apoptotic signaling pathway; cysteine-type endopeptidase activity; cytosol; innate immune response; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteolysis; regulation of apoptotic process; ripoptosome IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] CASP10 MCH4 Homo sapiens (Human) TR22949_c1_g1_i3 O02002 CASP1_DROME 7.00E-07 GO:0007015; GO:0009267; GO:0006922; GO:0004197; GO:0007303; GO:0010623; GO:0009790; GO:1900074; GO:0016322; GO:0045476; GO:0016239; GO:0035071 "actin filament organization; cellular response to starvation; cleavage of lamin involved in execution phase of apoptosis; cysteine-type endopeptidase activity; cytoplasmic transport, nurse cell to oocyte; developmental programmed cell death; embryo development; negative regulation of neuromuscular synaptic transmission; neuron remodeling; nurse cell apoptotic process; positive regulation of macroautophagy; salivary gland cell autophagic cell death" IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-1 (EC 3.4.22.-) [Cleaved into: Caspase-1 subunit p22; Caspase-1 subunit p13] Dcp-1 CG5370 Drosophila melanogaster (Fruit fly) TR22955_c2_g1_i1 Q7L0X2 F194A_HUMAN 2.00E-24 Protein FAM194A FAM194A C3orf44 Homo sapiens (Human) TR2296_c0_g2_i1 Q7T3T9 ZAR1_TAKRU 2.00E-06 GO:0005737; GO:0007275 cytoplasm; multicellular organismal development IPR026775; IPR027377; Zygote arrest protein 1 (Oocyte-specific maternal effect factor) zar1 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR22968_c0_g1_i1 P86854 PLCL_MYTGA 1.00E-17 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR22969_c0_g2_i2 Q6IMN6 CAPR2_HUMAN 3.00E-11 GO:0003723; GO:0005739; GO:0030308; GO:0017148; GO:0090263; GO:0050775; GO:0061003; GO:0033138; GO:0032092; GO:0045944; GO:0043235 O75197 RNA binding; mitochondrion; negative regulation of cell growth; negative regulation of translation; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of dendrite morphogenesis; positive regulation of dendritic spine morphogenesis; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of transcription from RNA polymerase II promoter; receptor complex IPR001073; IPR022070; IPR008983; Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (Gastric cancer multidrug resistance-associated protein) (Protein EEG-1) (RNA granule protein 140) CAPRIN2 C1QDC1 EEG1 KIAA1873 RNG140 Homo sapiens (Human) TR2297_c0_g1_i1 Q8BQN6 OZF_MOUSE 2.00E-19 GO:0003677; GO:0005737; GO:0046872; GO:0005730 DNA binding; cytoplasm; metal ion binding; nucleolus IPR007087; IPR015880; IPR013087; Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146) Znf146 Ozf Zfp146 Mus musculus (Mouse) TR22971_c0_g2_i1 O35623 BET1_MOUSE 1.00E-14 GO:0006888; GO:0031985; GO:0000139; GO:0005801; GO:0005789; GO:0016021; GO:0015031; GO:0048280 ER to Golgi vesicle-mediated transport; Golgi cisterna; Golgi membrane; cis-Golgi network; endoplasmic reticulum membrane; integral to membrane; protein transport; vesicle fusion with Golgi apparatus IPR000727; BET1 homolog (mBET1) (Golgi vesicular membrane-trafficking protein p18) Bet1 Mus musculus (Mouse) TR2298_c0_g1_i1 Q3UQI9 F188B_MOUSE 8.00E-23 IPR025257; Protein FAM188B Fam188b Mus musculus (Mouse) TR22981_c4_g1_i1 Q15643 TRIPB_HUMAN 2.00E-16 GO:0005794; GO:0005856; GO:0016020; GO:0005634; GO:0000042; GO:0003713; GO:0006366; GO:0003281 Golgi apparatus; cytoskeleton; membrane; nucleus; protein targeting to Golgi; transcription coactivator activity; transcription from RNA polymerase II promoter; ventricular septum development IPR000237; Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) TRIP11 CEV14 Homo sapiens (Human) TR22988_c0_g1_i1 P11926 DCOR_HUMAN 1.00E-53 GO:0005829; GO:0001822; GO:0004586; GO:0006596; GO:0008284; GO:0033387; GO:0006521; GO:0009615; GO:0044281 O95190 cytosol; kidney development; ornithine decarboxylase activity; polyamine biosynthetic process; positive regulation of cell proliferation; putrescine biosynthetic process from ornithine; regulation of cellular amino acid metabolic process; response to virus; small molecule metabolic process IPR009006; IPR022643; IPR022657; IPR022644; IPR022653; IPR000183; IPR002433; Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1. Ornithine decarboxylase (ODC) (EC 4.1.1.17) ODC1 Homo sapiens (Human) TR22988_c1_g1_i1 Q9UQW9 DCOR_SCHPO 2.00E-45 GO:0005829; GO:0005634; GO:0019467; GO:0004586; GO:0015940; GO:0033387 "cytosol; nucleus; ornithine catabolic process, by decarboxylation; ornithine decarboxylase activity; pantothenate biosynthetic process; putrescine biosynthetic process from ornithine" IPR009006; IPR022643; IPR022644; IPR022653; IPR000183; IPR002433; Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1. Ornithine decarboxylase (ODC) (EC 4.1.1.17) spe1 SPAC144.04c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR22989_c0_g1_i1 Q7T105 MIER1_XENLA 8.00E-72 GO:0003677; GO:0003682; GO:0031937; GO:0006351; GO:0017053 "DNA binding; chromatin binding; positive regulation of chromatin silencing; transcription, DNA-dependent; transcriptional repressor complex" IPR000949; IPR009057; IPR001005; IPR017884; Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (Xmi-er1) mier1 Xenopus laevis (African clawed frog) TR22996_c0_g2_i1 O09131 GSTO1_MOUSE 4.00E-06 GO:0019852; GO:0071243; GO:0005737; GO:0005829; GO:0045174; GO:0004364; GO:0050610; GO:0060315; GO:0060316; GO:0010880; GO:0042178 L-ascorbic acid metabolic process; cellular response to arsenic-containing substance; cytoplasm; cytosol; glutathione dehydrogenase (ascorbate) activity; glutathione transferase activity; methylarsonate reductase activity; negative regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of ryanodine-sensitive calcium-release channel activity; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; xenobiotic catabolic process IPR010987; IPR004045; IPR004046; IPR005442; IPR012336; Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R) (p28) Gsto1 Gstx Gtsttl Mus musculus (Mouse) TR22998_c1_g1_i1 Q93009 UBP7_HUMAN 1.00E-14 GO:0016605; GO:0004197; GO:0005829; GO:0010216; GO:0019048; GO:0007275; GO:0032088; GO:0005634; GO:0002039; GO:0016579; GO:0006283; GO:0004221; GO:0006511; GO:0004843 P35226; Q9HC52; Q9UER7; P03211; P21145; Q00987; O15151; O35618; Q5U5Q3; Q99836; P35227; Q06587; Q99496; P84022; Q99426; P04637; Q86VY4 PML body; cysteine-type endopeptidase activity; cytosol; maintenance of DNA methylation; modulation by virus of host morphology or physiology; multicellular organismal development; negative regulation of NF-kappaB transcription factor activity; nucleus; p53 binding; protein deubiquitination; transcription-coupled nucleotide-excision repair; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR002083; IPR018200; IPR001394; IPR008974; IPR024729; Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) USP7 HAUSP Homo sapiens (Human) TR23001_c0_g1_i1 Q86WV6 TM173_HUMAN 3.00E-08 GO:0005794; GO:0002218; GO:0006915; GO:0071360; GO:0035458; GO:0061507; GO:0035438; GO:0030659; GO:0051607; GO:0005789; GO:0045087; GO:0016021; GO:0032608; GO:0005741; GO:0048471; GO:0005777; GO:0005886; GO:0002230; GO:0032092; GO:0033160; GO:0042993; GO:0045944; GO:0032481; GO:0042803; GO:0019901; GO:0008134 Itself; P27958; Q99IB8; Q96A33; P39656; Q16666; P51617; O94822; Q7Z434; Q96N66; O95470; P42226; P46977; O15260; Q9UHD2 "Golgi apparatus; activation of innate immune response; apoptotic process; cellular response to exogenous dsRNA; cellular response to interferon-beta; cyclic-GMP-AMP binding; cyclic-di-GMP binding; cytoplasmic vesicle membrane; defense response to virus; endoplasmic reticulum membrane; innate immune response; integral to membrane; interferon-beta production; mitochondrial outer membrane; perinuclear region of cytoplasm; peroxisome; plasma membrane; positive regulation of defense response to virus by host; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of type I interferon production; protein homodimerization activity; protein kinase binding; transcription factor binding" Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173) TMEM173 ERIS MITA STING Homo sapiens (Human) TR23001_c3_g1_i1 A8E5V9 TM173_XENTR 4.00E-07 GO:0002218; GO:0006915; GO:0061507; GO:0035438; GO:0051607; GO:0005789; GO:0045087; GO:0016021; GO:0032608; GO:0005741; GO:0048471; GO:0005886; GO:0042803 activation of innate immune response; apoptotic process; cyclic-GMP-AMP binding; cyclic-di-GMP binding; defense response to virus; endoplasmic reticulum membrane; innate immune response; integral to membrane; interferon-beta production; mitochondrial outer membrane; perinuclear region of cytoplasm; plasma membrane; protein homodimerization activity Stimulator of interferon genes protein (STING) (Transmembrane protein 173) tmem173 sting Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR23002_c0_g1_i1 Q4R793 SGK71_MACFA 4.00E-08 GO:0005524; GO:0004672 ATP binding; protein kinase activity IPR016024; IPR011009; IPR000719; Probable inactive protein kinase-like protein SgK071 (Sugen kinase 071) SGK071 QtsA-15869 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR23006_c0_g1_i1 B0BLS0 OST4_RAT 2.00E-12 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR018943; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 Ost4 Rattus norvegicus (Rat) TR23009_c1_g1_i1 Q6DDL7 UN93A_XENLA 1.00E-27 GO:0016021 integral to membrane IPR010291; IPR016196; Protein unc-93 homolog A (Unc-93A) unc93a Xenopus laevis (African clawed frog) TR23009_c2_g1_i1 Q9Y115 UN93L_DROME 3.00E-36 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR010291; IPR016196; UNC93-like protein CG4928 Drosophila melanogaster (Fruit fly) TR23010_c0_g2_i1 Q0V9Y8 LRC42_XENTR 3.00E-25 Leucine-rich repeat-containing protein 42 lrrc42 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR23014_c0_g1_i1 P82595 PLS_HALLA 3.00E-13 GO:0005576; GO:0001558 extracellular region; regulation of cell growth IPR009030; IPR000867; IPR017891; Perlustrin Haliotis laevigata (Abalone) TR23016_c0_g1_i1 P52503 NDUS6_MOUSE 9.00E-21 GO:0072358; GO:0006631; GO:0005747; GO:0005739; GO:0070584; GO:0035264; GO:0010259; GO:0006936; GO:0061458; GO:0022904 cardiovascular system development; fatty acid metabolic process; mitochondrial respiratory chain complex I; mitochondrion; mitochondrion morphogenesis; multicellular organism growth; multicellular organismal aging; muscle contraction; reproductive system development; respiratory electron transport chain IPR016668; IPR019401; "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit)" Ndufs6 Ip13 Mus musculus (Mouse) TR23016_c0_g1_i3 P23934 NDUS6_BOVIN 2.00E-19 GO:0005743; GO:0055114; GO:0070469 mitochondrial inner membrane; oxidation-reduction process; respiratory chain IPR016668; IPR019401; "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit)" NDUFS6 Bos taurus (Bovine) TR23017_c2_g1_i1 Q58E03 DJC25_XENLA 1.00E-70 GO:0016021 integral to membrane IPR001623; IPR018253; DnaJ homolog subfamily C member 25 dnajc25 Xenopus laevis (African clawed frog) TR23018_c4_g1_i1 O93852 ALO_CANAL 5.00E-10 GO:0003885; GO:0008762; GO:0009058; GO:0034599; GO:0009267; GO:0036170; GO:0050660; GO:0031966; GO:0005739; GO:0009405; GO:0005886; GO:0006767 "D-arabinono-1,4-lactone oxidase activity; UDP-N-acetylmuramate dehydrogenase activity; biosynthetic process; cellular response to oxidative stress; cellular response to starvation; filamentous growth of a population of unicellular organisms in response to starvation; flavin adenine dinucleotide binding; mitochondrial membrane; mitochondrion; pathogenesis; plasma membrane; water-soluble vitamin metabolic process" IPR007173; IPR016169; IPR016166; IPR016167; IPR010031; IPR023595; IPR006094; IPR006093; "Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2." "D-arabinono-1,4-lactone oxidase (ALO) (EC 1.1.3.37) (L-galactono-gamma-lactone oxidase)" ALO1 ALO CaO19.7551 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) TR23019_c0_g1_i1 Q9JI48 PLAC8_MOUSE 7.00E-19 GO:0050873; GO:0003682; GO:0042742; GO:0043066; GO:0040015; GO:0005634; GO:0008284; GO:0045944; GO:0009409 brown fat cell differentiation; chromatin binding; defense response to bacterium; negative regulation of apoptotic process; negative regulation of multicellular organism growth; nucleus; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; response to cold IPR006461; Placenta-specific gene 8 protein (Onzin) (Protein C15) Plac8 Mus musculus (Mouse) TR23019_c0_g1_i3 Q9BYD5 CNFN_HUMAN 1.00E-18 GO:0001533; GO:0005737; GO:0031424 cornified envelope; cytoplasm; keratinization IPR006461; Cornifelin CNFN Homo sapiens (Human) TR23021_c1_g1_i1 A4IGI5 TMM35_XENTR 4.00E-24 GO:0016023; GO:0016021; GO:0005778 cytoplasmic membrane-bounded vesicle; integral to membrane; peroxisomal membrane Transmembrane protein 35 tmem35 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR23023_c0_g1_i1 Q96DM1 PGBD4_HUMAN 5.00E-10 PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) TR23024_c1_g1_i1 Q97VF1 APE1_SULSO 3.00E-13 GO:0004177; GO:0005737; GO:0008237; GO:0006508; GO:0008270 aminopeptidase activity; cytoplasm; metallopeptidase activity; proteolysis; zinc ion binding IPR024571; IPR001930; IPR014782; Probable aminopeptidase 1 (EC 3.4.11.-) ape1 SSO2675 C30_037 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) TR23024_c1_g1_i2 Q10737 AMPN_HAECO 2.00E-25 GO:0004177; GO:0016021; GO:0008237; GO:0006508; GO:0008270 aminopeptidase activity; integral to membrane; metallopeptidase activity; proteolysis; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (AP-N) (EC 3.4.11.2) (Membrane glycoprotein H11) (Microsomal aminopeptidase) Haemonchus contortus (Barber pole worm) TR23024_c2_g1_i2 P79143 AMPN_CANFA 1.00E-31 GO:0004177; GO:0001525; GO:0030154; GO:0005793; GO:0009897; GO:0008237; GO:0019048; GO:0006508; GO:0009615; GO:0001618 aminopeptidase activity; angiogenesis; cell differentiation; endoplasmic reticulum-Golgi intermediate compartment; external side of plasma membrane; metallopeptidase activity; modulation by virus of host morphology or physiology; proteolysis; response to virus; virus receptor activity IPR024571; IPR001930; Aminopeptidase N (AP-N) (cAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) (Fragment) ANPEP Canis familiaris (Dog) (Canis lupus familiaris) TR23026_c0_g1_i1 Q5PR73 DIRA2_MOUSE 4.00E-99 GO:0005525; GO:0003924; GO:0005886; GO:0007264 GTP binding; GTPase activity; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; GTP-binding protein Di-Ras2 (Distinct subgroup of the Ras family member 2) Diras2 Mus musculus (Mouse) TR23027_c2_g1_i1 Q6ZSM3 MOT12_HUMAN 3.00E-22 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) SLC16A12 MCT12 Homo sapiens (Human) TR23027_c3_g2_i1 Q8R0M8 MOT5_MOUSE 2.00E-16 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 5 (MCT 5) Slc16a4 Mct5 Mus musculus (Mouse) TR23027_c5_g1_i1 Q7RTX9 MOT14_HUMAN 3.00E-24 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR23029_c2_g1_i1 Q2LD37 K1109_HUMAN 1.00E-27 GO:0016021; GO:0016020; GO:0005634; GO:0001558; GO:0030856 P35222 integral to membrane; membrane; nucleus; regulation of cell growth; regulation of epithelial cell differentiation IPR018863; Uncharacterized protein KIAA1109 (Fragile site-associated protein) KIAA1109 FSA KIAA1371 Homo sapiens (Human) TR23030_c1_g1_i1 Q4UMH6 Y381_RICFE 7.00E-06 GO:0015969 guanosine tetraphosphate metabolic process IPR002110; IPR020683; IPR007685; Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR23030_c4_g1_i1 Q8ZWC4 Y1861_PYRAE 3.00E-07 IPR002110; IPR020683; Putative ankyrin repeat protein PAE1861 PAE1861 Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827) TR23035_c0_g1_i2 P41950 YLK2_CAEEL 3.00E-14 GO:0003391; GO:0005509; GO:0007160; GO:0032590; GO:0016021 amphid sensory organ dendrite retrograde extension; calcium ion binding; cell-matrix adhesion; dendrite membrane; integral to membrane IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR023413; IPR009030; IPR003886; EGF-like domain-containing protein D1044.2 D1044.2 Caenorhabditis elegans TR23038_c1_g1_i1 Q07722 PLCB4_BOVIN 5.00E-141 GO:0005509; GO:0035556; GO:0016042; GO:0004435; GO:0004871 calcium ion binding; intracellular signal transduction; lipid catabolic process; phosphatidylinositol phospholipase C activity; signal transducer activity IPR000008; IPR011992; IPR001192; IPR016280; IPR009535; IPR017946; IPR015359; IPR000909; IPR001711; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (PCL-C1) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4) (Fragment)" PLCB4 Bos taurus (Bovine) TR23042_c0_g1_i1 P31584 YPTV1_VOLCA 6.00E-30 GO:0005525; GO:0005886; GO:0015031; GO:0007264 GTP binding; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; GTP-binding protein yptV1 YPTV1 Volvox carteri (Green alga) TR23045_c1_g1_i2 B2JS89 BETA_BURP8 1.00E-12 GO:0008802; GO:0008812; GO:0050660; GO:0019285 betaine-aldehyde dehydrogenase activity; choline dehydrogenase activity; flavin adenine dinucleotide binding; glycine betaine biosynthetic process from choline IPR011533; IPR012132; IPR000172; IPR007867; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. Oxygen-dependent choline dehydrogenase (CDH) (CHD) (EC 1.1.99.1) (Betaine aldehyde dehydrogenase) (BADH) (EC 1.2.1.8) betA Bphy_3310 Burkholderia phymatum (strain DSM 17167 / STM815) TR2305_c0_g1_i1 Q9Y253 POLH_HUMAN 9.00E-10 GO:0006260; GO:0000731; GO:0003887; GO:0005737; GO:0003684; GO:0046872; GO:0005654; GO:0006301; GO:0006290; GO:0006282; GO:0010225 Q6FI35; P0CG48 DNA replication; DNA synthesis involved in DNA repair; DNA-directed DNA polymerase activity; cytoplasm; damaged DNA binding; metal ion binding; nucleoplasm; postreplication repair; pyrimidine dimer repair; regulation of DNA repair; response to UV-C IPR017061; IPR017961; IPR001126; IPR017963; DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) POLH RAD30 RAD30A XPV Homo sapiens (Human) TR23050_c0_g1_i1 Q8K1K6 SPB10_MOUSE 4.00E-23 GO:0005737; GO:0005615; GO:0005634; GO:0030162; GO:0004867 cytoplasm; extracellular space; nucleus; regulation of proteolysis; serine-type endopeptidase inhibitor activity IPR023795; IPR023796; IPR000215; Serpin B10 Serpinb10 Mus musculus (Mouse) TR23053_c1_g1_i1 Q9U641 CMFB_DICDI 3.00E-64 GO:0016021; GO:0055114; GO:0016491 integral to membrane; oxidation-reduction process; oxidoreductase activity IPR002938; IPR003042; Conditioned medium factor receptor 1 cmfB cmfr1 DDB_G0289157 Dictyostelium discoideum (Slime mold) TR23056_c0_g1_i1 Q9TXQ1 PME5_CAEEL 5.00E-42 GO:0006281; GO:0003950; GO:0043069; GO:0005634; GO:0006471 DNA repair; NAD+ ADP-ribosyltransferase activity; negative regulation of programmed cell death; nucleus; protein ADP-ribosylation IPR002110; IPR020683; IPR012317; IPR004102; IPR008893; Poly(ADP-ribose) polymerase pme-5 (EC 2.4.2.30) (Poly ADP-ribose metabolism enzyme 5) pme-5 ZK1005.1 Caenorhabditis elegans TR23056_c4_g1_i1 O75762 TRPA1_HUMAN 2.00E-12 GO:0005262; GO:0015267; GO:0050968; GO:0050966; GO:0005887; GO:0006811; GO:0009409; GO:0042493; GO:0042542; GO:0048265; GO:0032421; GO:0050955 calcium channel activity; channel activity; detection of chemical stimulus involved in sensory perception of pain; detection of mechanical stimulus involved in sensory perception of pain; integral to plasma membrane; ion transport; response to cold; response to drug; response to hydrogen peroxide; response to pain; stereocilium bundle; thermoception IPR002110; IPR020683; IPR005821; Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) TRPA1 ANKTM1 Homo sapiens (Human) TR23056_c4_g2_i1 Q91955 MTPN_CHICK 3.00E-06 GO:0030424; GO:0005829; GO:0005634; GO:0048471; GO:0051092; GO:0010613; GO:0030307; GO:0010557; GO:0051247; GO:2000812 axon; cytosol; nucleus; perinuclear region of cytoplasm; positive regulation of NF-kappaB transcription factor activity; positive regulation of cardiac muscle hypertrophy; positive regulation of cell growth; positive regulation of macromolecule biosynthetic process; positive regulation of protein metabolic process; regulation of barbed-end actin filament capping IPR002110; IPR020683; Myotrophin (Granule cell differentiation protein) (Protein V-1) MTPN RCJMB04_23o21 RCJMB04_35l16 Gallus gallus (Chicken) TR23061_c0_g1_i1 Q9JJ80 RPF2_MOUSE 7.00E-138 GO:0005730 nucleolus IPR007109; Ribosome production factor 2 homolog (Brix domain-containing protein 1) (Ribosome biogenesis protein RPF2 homolog) Rpf2 Bxdc1 MNCb-4285 Mus musculus (Mouse) TR23069_c1_g1_i1 P25291 GP2_CANFA 6.00E-10 GO:0031225; GO:0005576; GO:0005886 anchored to membrane; extracellular region; plasma membrane IPR001507; IPR017977; Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) GP2 Canis familiaris (Dog) (Canis lupus familiaris) TR23069_c1_g2_i1 P07911 UROM_HUMAN 1.00E-10 GO:0005794; GO:0031225; GO:0016324; GO:0016323; GO:0005509; GO:0006968; GO:0048878; GO:0060170; GO:0031410; GO:0007588; GO:0005615; GO:0019898; GO:0045121; GO:0072218; GO:0072221; GO:0072233; GO:0008285; GO:0072372; GO:2000021; GO:0010033; GO:0000922 Golgi apparatus; anchored to membrane; apical plasma membrane; basolateral plasma membrane; calcium ion binding; cellular defense response; chemical homeostasis; cilium membrane; cytoplasmic vesicle; excretion; extracellular space; extrinsic to membrane; membrane raft; metanephric ascending thin limb development; metanephric distal convoluted tubule development; metanephric thick ascending limb development; negative regulation of cell proliferation; primary cilium; regulation of ion homeostasis; response to organic substance; spindle pole IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR023413; IPR009030; IPR001507; IPR017977; "Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]" UMOD Homo sapiens (Human) TR23069_c1_g3_i1 P19218 GP2_RAT 1.00E-11 GO:0031225; GO:0005576; GO:0005886 anchored to membrane; extracellular region; plasma membrane IPR001507; IPR017977; Pancreatic secretory granule membrane major glycoprotein GP2 (Glycoprotein 80) (gp80) (Pancreatic zymogen granule membrane protein GP-2) Gp2 Rattus norvegicus (Rat) TR23072_c1_g1_i1 Q6DHG8 SKA1_DANRE 2.00E-20 GO:0051301; GO:0007059; GO:0000940; GO:0005737; GO:0008017; GO:0007067; GO:0031110; GO:0005876 cell division; chromosome segregation; condensed chromosome outer kinetochore; cytoplasm; microtubule binding; mitosis; regulation of microtubule polymerization or depolymerization; spindle microtubule IPR009829; Spindle and kinetochore-associated protein 1 ska1 zgc:92321 Danio rerio (Zebrafish) (Brachydanio rerio) TR23073_c0_g2_i1 A7M9B2 YCF1_CUSRE 4.00E-06 GO:0016021; GO:0042170 integral to membrane; plastid membrane IPR008896; Putative membrane protein ycf1 ycf1 Cuscuta reflexa (Southern Asian dodder) TR23074_c0_g1_i1 Q9ASS6 CP20B_ARATH 5.00E-61 GO:0010275; GO:0031969; GO:0009533; GO:0009543; GO:0009535; GO:0042277; GO:0003755; GO:0006457; GO:0031977 Q9C5U2 NAD(P)H dehydrogenase complex assembly; chloroplast membrane; chloroplast stromal thylakoid; chloroplast thylakoid lumen; chloroplast thylakoid membrane; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein folding; thylakoid lumen IPR002130; IPR020892; "Peptidyl-prolyl cis-trans isomerase CYP20-2, chloroplastic (PPIase CYP20-2) (EC 5.2.1.8) (Cyclophilin of 20 kDa 2) (Rotamase CYP20-2) (Thylakoid lumen PPIase of 20 kDa) (TLP20)" CYP20-2 At5g13120 T19L5_80 Arabidopsis thaliana (Mouse-ear cress) TR23074_c0_g2_i1 Q39613 CYPH_CATRO 3.00E-76 GO:0005737; GO:0042277; GO:0003755; GO:0006457; GO:0000413 cytoplasm; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Cyclophilin) (Cyclosporin A-binding protein) (Rotamase) PCKR1 Catharanthus roseus (Madagascar periwinkle) (Vinca rosea) TR23075_c1_g1_i1 Q08DY9 CASP3_BOVIN 8.00E-35 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Bos taurus (Bovine) TR23084_c0_g1_i1 Q96KG7 MEG10_HUMAN 6.00E-17 GO:0016323; GO:0042995; GO:0034109; GO:0016021; GO:0055001; GO:0001891; GO:0043654; GO:0051147; GO:0048641; GO:0014719; GO:0014816; GO:0014841 basolateral plasma membrane; cell projection; homotypic cell-cell adhesion; integral to membrane; muscle cell development; phagocytic cup; recognition of apoptotic cell; regulation of muscle cell differentiation; regulation of skeletal muscle tissue development; satellite cell activation; satellite cell differentiation; satellite cell proliferation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) TR23084_c0_g1_i2 Q80V70 MEGF6_MOUSE 1.00E-12 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR013111; IPR002049; IPR011489; IPR009030; Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) TR23091_c0_g1_i1 Q26474 LACH_SCHAM 2.00E-13 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Lachesin LAC Schistocerca americana (American grasshopper) TR23096_c0_g1_i1 Q62255 SALL3_MOUSE 4.00E-42 GO:0003677; GO:0035136; GO:0035137; GO:0046872; GO:0045879; GO:0005634; GO:0021891; GO:0006355; GO:0006351 "DNA binding; forelimb morphogenesis; hindlimb morphogenesis; metal ion binding; negative regulation of smoothened signaling pathway; nucleus; olfactory bulb interneuron development; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Sal-like protein 3 (MSal) (Spalt-like protein 3) Sall3 Sal Mus musculus (Mouse) TR23097_c0_g1_i1 Q924H0 NPFF2_MOUSE 6.00E-38 GO:0015629; GO:0005887; GO:0008188; GO:0007218; GO:0043408; GO:0045761; GO:2000479 actin cytoskeleton; integral to plasma membrane; neuropeptide receptor activity; neuropeptide signaling pathway; regulation of MAPK cascade; regulation of adenylate cyclase activity; regulation of cAMP-dependent protein kinase activity IPR000276; IPR017452; IPR005395; IPR005397; Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide NPFF receptor) Npffr2 Gpr74 Npff2 Mus musculus (Mouse) TR23097_c0_g2_i1 P22270 OAR_DROME 4.00E-13 GO:0008227; GO:0005887; GO:0007211; GO:0004989; GO:1900738; GO:0010578; GO:0007608 G-protein coupled amine receptor activity; integral to plasma membrane; octopamine or tyramine signaling pathway; octopamine receptor activity; positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway; regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway; sensory perception of smell IPR000276; IPR017452; IPR002002; Tyramine/octopamine receptor (Tyr/Oct-Dro) Oct-TyrR OcR OctyR99AB TYR TyrR CG7485 Drosophila melanogaster (Fruit fly) TR23104_c0_g1_i1 Q9BV94 EDEM2_HUMAN 6.00E-34 GO:0005509; GO:0005788; GO:0005789; GO:0005576; GO:0043687; GO:0018279; GO:0006457; GO:0006986 calcium ion binding; endoplasmic reticulum lumen; endoplasmic reticulum membrane; extracellular region; post-translational protein modification; protein N-linked glycosylation via asparagine; protein folding; response to unfolded protein IPR001382; ER degradation-enhancing alpha-mannosidase-like protein 2 EDEM2 C20orf31 C20orf49 UNQ573/PRO1135 Homo sapiens (Human) TR23104_c1_g1_i1 A1D1W1 MNS1B_NEOFI 9.00E-06 GO:0005509; GO:0060205; GO:0004571; GO:0016020; GO:0006486 "calcium ion binding; cytoplasmic membrane-bounded vesicle lumen; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; membrane; protein glycosylation" IPR001382; Protein modification; protein glycosylation. "Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B (EC 3.2.1.113) (Class I alpha-mannosidase 1B) (Man(9)-alpha-mannosidase 1B)" mns1B msdS NFIA_010860 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) TR23110_c2_g1_i1 Q4KUS2 UN13A_MOUSE 0 GO:0050435; GO:0030054; GO:0005737; GO:0019992; GO:0060384; GO:0035556; GO:0046872; GO:0031594; GO:0007528; GO:0001956; GO:0042734; GO:0048172; GO:0035249; GO:0016081; GO:0016188; GO:0016082 "beta-amyloid metabolic process; cell junction; cytoplasm; diacylglycerol binding; innervation; intracellular signal transduction; metal ion binding; neuromuscular junction; neuromuscular junction development; positive regulation of neurotransmitter secretion; presynaptic membrane; regulation of short-term neuronal synaptic plasticity; synaptic transmission, glutamatergic; synaptic vesicle docking involved in exocytosis; synaptic vesicle maturation; synaptic vesicle priming" IPR000008; IPR010439; IPR014770; IPR014772; IPR019558; IPR002219; IPR027080; IPR027082; Protein unc-13 homolog A (Munc13-1) Unc13a Mus musculus (Mouse) TR23110_c3_g2_i1 B2RUP2 UN13D_MOUSE 2.00E-06 GO:0051607; GO:0070382; GO:0002467; GO:0002432; GO:0005770; GO:0005764; GO:0016020; GO:0043320; GO:0006909; GO:0045921; GO:0055037; GO:0043304 defense response to virus; exocytic vesicle; germinal center formation; granuloma formation; late endosome; lysosome; membrane; natural killer cell degranulation; phagocytosis; positive regulation of exocytosis; recycling endosome; regulation of mast cell degranulation IPR000008; IPR014770; IPR014772; IPR019558; Protein unc-13 homolog D (Munc13-4) Unc13d Mus musculus (Mouse) TR23110_c3_g2_i2 O94812 BAIP3_HUMAN 3.00E-07 GO:0007186; GO:0007269; GO:0008022 G-protein coupled receptor signaling pathway; neurotransmitter secretion; protein C-terminus binding IPR000008; IPR014770; IPR014772; IPR019558; BAI1-associated protein 3 (BAP3) BAIAP3 KIAA0734 Homo sapiens (Human) TR23110_c4_g1_i1 Q9Z1N9 UN13B_MOUSE 6.00E-90 GO:0005794; GO:0030054; GO:0019992; GO:0060384; GO:0035556; GO:0016020; GO:0046872; GO:0031594; GO:0007528; GO:0001566; GO:0048172; GO:0035249; GO:0016081; GO:0016082 "Golgi apparatus; cell junction; diacylglycerol binding; innervation; intracellular signal transduction; membrane; metal ion binding; neuromuscular junction; neuromuscular junction development; non-kinase phorbol ester receptor activity; regulation of short-term neuronal synaptic plasticity; synaptic transmission, glutamatergic; synaptic vesicle docking involved in exocytosis; synaptic vesicle priming" IPR000008; IPR010439; IPR014770; IPR014772; IPR019558; IPR002219; IPR027080; Protein unc-13 homolog B (Munc13-2) (munc13) Unc13b Unc13a Mus musculus (Mouse) TR23111_c2_g2_i1 Q6INS1 FBXL5_XENLA 4.00E-38 GO:0019005; GO:0031146; GO:0005506; GO:0055072; GO:0048471; GO:0016567 SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; iron ion binding; iron ion homeostasis; perinuclear region of cytoplasm; protein ubiquitination IPR001810; IPR012312; Protein modification; protein ubiquitination. F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5) fbxl5 Xenopus laevis (African clawed frog) TR23113_c0_g1_i1 Q9NZE8 RM35_HUMAN 1.00E-20 GO:0005761; GO:0003735; GO:0006412 mitochondrial ribosome; structural constituent of ribosome; translation IPR019338; IPR021137; "39S ribosomal protein L35, mitochondrial (L35mt) (MRP-L35)" MRPL35 BM-007 Homo sapiens (Human) TR23114_c1_g1_i1 P0C6Y7 PRDM9_RAT 8.00E-24 GO:0005694; GO:0034968; GO:0018024; GO:0007126; GO:0046872; GO:0003676; GO:0005634; GO:0006355; GO:0006351 "chromosome; histone lysine methylation; histone-lysine N-methyltransferase activity; meiosis; metal ion binding; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR003655; IPR001214; IPR019041; IPR007087; IPR015880; IPR013087; Histone-lysine N-methyltransferase PRDM9 (EC 2.1.1.43) (PR domain zinc finger protein 9) (PR domain-containing protein 9) Prdm9 Rattus norvegicus (Rat) TR23115_c1_g1_i1 P70031 CCKAR_XENLA 4.00E-25 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR009126; IPR000276; IPR017452; Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) TR23122_c2_g1_i1 Q8NE09 RGS22_HUMAN 2.00E-48 GO:0005096; GO:0005737; GO:0005886; GO:0038032 GTPase activator activity; cytoplasm; plasma membrane; termination of G-protein coupled receptor signaling pathway IPR016137; IPR000342; Regulator of G-protein signaling 22 (RGS22) RGS22 Homo sapiens (Human) TR23123_c2_g1_i1 A6NHY2 AKD1B_HUMAN 2.00E-06 GO:0007165 signal transduction IPR002110; IPR020683; IPR011029; IPR000488; Ankyrin repeat and death domain-containing protein 1B ANKDD1B Homo sapiens (Human) TR23130_c0_g1_i1 Q69ZQ2 ISY1_MOUSE 9.00E-120 GO:0008380; GO:0006397; GO:0005681 RNA splicing; mRNA processing; spliceosomal complex IPR009360; Pre-mRNA-splicing factor ISY1 homolog Isy1 Kiaa1160 Mus musculus (Mouse) TR23133_c0_g1_i1 Q02357 ANK1_MOUSE 4.00E-27 GO:0030863; GO:0048821; GO:0016020; GO:0015672; GO:0006779; GO:0016529; GO:0007165; GO:0014731 cortical cytoskeleton; erythrocyte development; membrane; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; sarcoplasmic reticulum; signal transduction; spectrin-associated cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) TR23137_c0_g1_i1 P09478 ACH1_DROME 9.00E-33 GO:0004889; GO:0005892; GO:0030054; GO:0045211; GO:0017085; GO:0007271 "acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; postsynaptic membrane; response to insecticide; synaptic transmission, cholinergic" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha-like 1 nAcRalpha-96Aa Acr96Aa AcrB als CG5610 Drosophila melanogaster (Fruit fly) TR23140_c0_g1_i1 Q9DGB6 TLR22_CHICK 3.00E-23 GO:0002755; GO:0042494; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0034134; GO:0002224; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; detection of bacterial lipoprotein; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; toll-like receptor 2 signaling pathway; toll-like receptor signaling pathway; transmembrane signaling receptor activity IPR000483; IPR018247; IPR001611; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 type-2 TLR2-2 Gallus gallus (Chicken) TR23147_c1_g3_i1 O14326 PUB3_SCHPO 5.00E-08 GO:0005543; GO:0006511; GO:0004842 phospholipid binding; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000008; IPR024928; IPR000569; IPR001202; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase pub3 (EC 6.3.2.-) pub3 SPBC16E9.11c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR23149_c0_g1_i1 Q5E9S3 TCF21_BOVIN 8.00E-36 GO:0070888; GO:0001078; GO:0001077; GO:0060008; GO:0001658; GO:0014707; GO:0060435; GO:0060539; GO:0048557; GO:0048732; GO:0048286; GO:0060425; GO:0060426; GO:0072277; GO:0072162; GO:0060766; GO:0005634; GO:0060021; GO:0007530; GO:0048536 E-box binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; Sertoli cell differentiation; branching involved in ureteric bud morphogenesis; branchiomeric skeletal muscle development; bronchiole development; diaphragm development; embryonic digestive tract morphogenesis; gland development; lung alveolus development; lung morphogenesis; lung vasculature development; metanephric glomerular capillary formation; metanephric mesenchymal cell differentiation; negative regulation of androgen receptor signaling pathway; nucleus; palate development; sex determination; spleen development IPR011598; Transcription factor 21 (TCF-21) TCF21 Bos taurus (Bovine) TR23150_c0_g1_i1 Q09326 MGAT2_RAT 2.00E-63 GO:0000139; GO:0005795; GO:0008455; GO:0030246; GO:0016021; GO:0009312; GO:0006487; GO:0018279 "Golgi membrane; Golgi stack; alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity; carbohydrate binding; integral to membrane; oligosaccharide biosynthetic process; protein N-linked glycosylation; protein N-linked glycosylation via asparagine" IPR007754; Protein modification; protein glycosylation. "Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143) (Beta-1,2-N-acetylglucosaminyltransferase II) (GlcNAc-T II) (GNT-II) (Mannoside acetylglucosaminyltransferase 2) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II)" Mgat2 Gnt2 Rattus norvegicus (Rat) TR23161_c1_g2_i1 Q9EQW7 KI13A_MOUSE 4.00E-53 GO:0005524; GO:0000139; GO:0043001; GO:0035459; GO:0005813; GO:0000910; GO:0010008; GO:0008333; GO:0005871; GO:0032438; GO:0005874; GO:0003777; GO:0030496; GO:0072383; GO:0032588 ATP binding; Golgi membrane; Golgi to plasma membrane protein transport; cargo loading into vesicle; centrosome; cytokinesis; endosome membrane; endosome to lysosome transport; kinesin complex; melanosome organization; microtubule; microtubule motor activity; midbody; plus-end-directed vesicle transport along microtubule; trans-Golgi network membrane IPR000253; IPR022140; IPR022164; IPR027640; IPR019821; IPR001752; IPR027417; IPR008984; Kinesin-like protein KIF13A Kif13a Mus musculus (Mouse) TR23161_c2_g1_i1 Q15058 KIF14_HUMAN 2.00E-10 GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0007018; GO:0005634; GO:0005819 O46385 ATP binding; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement; nucleus; spindle IPR000253; IPR027640; IPR019821; IPR001752; IPR027417; IPR008984; Kinesin-like protein KIF14 KIF14 KIAA0042 Homo sapiens (Human) TR23162_c1_g2_i1 Q8WTV0 SCRB1_HUMAN 6.00E-22 GO:0005545; GO:0051856; GO:0006702; GO:0043534; GO:0005901; GO:0007155; GO:0009986; GO:0006707; GO:0033344; GO:0042632; GO:0070508; GO:0032497; GO:0030666; GO:0001935; GO:0008035; GO:0034384; GO:0070506; GO:0034375; GO:0005887; GO:0001530; GO:0001875; GO:0015920; GO:0042157; GO:0030169; GO:0034383; GO:0005765; GO:0031528; GO:0019048; GO:0001786; GO:0015914; GO:0010886; GO:0010595; GO:0051000; GO:0010867; GO:0043654; GO:0050764; GO:0010899; GO:0043691; GO:0044281; GO:0005215; GO:0070328; GO:0042060 1-phosphatidylinositol binding; adhesion to symbiont; androgen biosynthetic process; blood vessel endothelial cell migration; caveola; cell adhesion; cell surface; cholesterol catabolic process; cholesterol efflux; cholesterol homeostasis; cholesterol import; detection of lipopolysaccharide; endocytic vesicle membrane; endothelial cell proliferation; high-density lipoprotein particle binding; high-density lipoprotein particle clearance; high-density lipoprotein particle receptor activity; high-density lipoprotein particle remodeling; integral to plasma membrane; lipopolysaccharide binding; lipopolysaccharide receptor activity; lipopolysaccharide transport; lipoprotein metabolic process; low-density lipoprotein particle binding; low-density lipoprotein particle clearance; lysosomal membrane; microvillus membrane; modulation by virus of host morphology or physiology; phosphatidylserine binding; phospholipid transport; positive regulation of cholesterol storage; positive regulation of endothelial cell migration; positive regulation of nitric-oxide synthase activity; positive regulation of triglyceride biosynthetic process; recognition of apoptotic cell; regulation of phagocytosis; regulation of phosphatidylcholine catabolic process; reverse cholesterol transport; small molecule metabolic process; transporter activity; triglyceride homeostasis; wound healing IPR002159; IPR005428; "Scavenger receptor class B member 1 (SRB1) (CD36 and LIMPII analogous 1) (CLA-1) (CD36 antigen-like 1) (Collagen type I receptor, thrombospondin receptor-like 1) (SR-BI) (CD antigen CD36)" SCARB1 CD36L1 CLA1 Homo sapiens (Human) TR23166_c4_g1_i1 Q93132 ACTM_BRAFL 5.00E-22 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin, muscle" Branchiostoma floridae (Florida lancelet) (Amphioxus) TR23166_c4_g2_i1 P53471 ACT2_SCHMA 6.00E-21 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; Actin-2 Schistosoma mansoni (Blood fluke) TR23166_c5_g1_i1 Q9UKK3 PARP4_HUMAN 1.00E-27 GO:0003677; GO:0006281; GO:0003950; GO:0008219; GO:0005737; GO:0019899; GO:0006954; GO:0005634; GO:0006471; GO:0042493; GO:0030529; GO:0005876; GO:0006810 Q9Q2G4 DNA binding; DNA repair; NAD+ ADP-ribosyltransferase activity; cell death; cytoplasm; enzyme binding; inflammatory response; nucleus; protein ADP-ribosylation; response to drug; ribonucleoprotein complex; spindle microtubule; transport IPR001357; IPR012317; IPR004102; IPR013694; IPR002035; Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) TR23168_c0_g1_i1 A8MXE2 YI036_HUMAN 7.00E-13 GO:0000139; GO:0008378; GO:0016021; GO:0006486 Golgi membrane; galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; "Putative UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase LOC402377 (EC 2.4.1.-)" Homo sapiens (Human) TR23169_c0_g1_i1 Q5SQM0 EMAL6_MOUSE 9.00E-51 GO:0005737; GO:0005874 cytoplasm; microtubule IPR005108; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like) Eml6 Eml5l Mus musculus (Mouse) TR23169_c1_g1_i1 Q9VUI3 EMAL_DROME 2.00E-08 GO:0008344; GO:0005737; GO:0035556; GO:0035011; GO:0005874; GO:0008017; GO:0071683; GO:0007605 adult locomotory behavior; cytoplasm; intracellular signal transduction; melanotic encapsulation of foreign target; microtubule; microtubule binding; sensory dendrite; sensory perception of sound IPR003533; IPR005108; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; Echinoderm microtubule-associated protein-like CG42247 DCX-EMAP CG42247 Drosophila melanogaster (Fruit fly) TR23170_c0_g1_i1 Q9JII1 INP5E_MOUSE 2.00E-61 GO:0032580; GO:0000139; GO:0035085; GO:0005856; GO:0046855; GO:0046856; GO:0004439 "Golgi cisterna membrane; Golgi membrane; cilium axoneme; cytoskeleton; inositol phosphate dephosphorylation; phosphatidylinositol dephosphorylation; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity" IPR005135; IPR000300; "72 kDa inositol polyphosphate 5-phosphatase (EC 3.1.3.36) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (Phosphatidylinositol polyphosphate 5-phosphatase type IV)" Inpp5e Mus musculus (Mouse) TR23174_c0_g1_i1 Q6P799 SYSC_RAT 0 GO:0005524; GO:0005737; GO:0097056; GO:0004828; GO:0006434 ATP binding; cytoplasm; selenocysteinyl-tRNA(Sec) biosynthetic process; serine-tRNA ligase activity; seryl-tRNA aminoacylation IPR002314; IPR006195; IPR002317; IPR015866; IPR010978; Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1. "Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)" Sars Sars1 Rattus norvegicus (Rat) TR23176_c0_g1_i1 Q6NYP0 TM208_DANRE 2.00E-34 GO:0006914; GO:0005789; GO:0016021 autophagy; endoplasmic reticulum membrane; integral to membrane IPR008506; Transmembrane protein 208 tmem208 zgc:77041 Danio rerio (Zebrafish) (Brachydanio rerio) TR23184_c0_g1_i1 Q9JLR1 S61A2_MOUSE 0 GO:0005789; GO:0016021; GO:0015031; GO:0043022 endoplasmic reticulum membrane; integral to membrane; protein transport; ribosome binding IPR002208; IPR023201; IPR019561; Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha-2) Sec61a2 Mus musculus (Mouse) TR23184_c0_g1_i2 Q60175 SECY_METJA 2.00E-55 GO:0016021; GO:0065002; GO:0005886; GO:0006605 integral to membrane; intracellular protein transmembrane transport; plasma membrane; protein targeting IPR026593; IPR002208; IPR023201; IPR019561; Protein translocase subunit SecY (Protein transport protein SEC61 subunit alpha homolog) secY MJ0478 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR23187_c0_g1_i1 Q9H2K2 TNKS2_HUMAN 2.00E-06 GO:0000139; GO:0003950; GO:0016055; GO:0046872; GO:0035264; GO:0000784; GO:0005635; GO:0000242; GO:0048471; GO:0090263; GO:0032212; GO:0070213; GO:0070198; GO:0000209; GO:0040014 O15084; O15169; Q9NWV8; P11274; Q6V0I7; Q9NWT6; Q92698; P78314; Q06649; O43815; P54274 "Golgi membrane; NAD+ ADP-ribosyltransferase activity; Wnt receptor signaling pathway; metal ion binding; multicellular organism growth; nuclear chromosome, telomeric region; nuclear envelope; pericentriolar material; perinuclear region of cytoplasm; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of telomere maintenance via telomerase; protein auto-ADP-ribosylation; protein localization to chromosome, telomeric region; protein polyubiquitination; regulation of multicellular organism growth" IPR002110; IPR020683; IPR012317; IPR001660; IPR013761; IPR011510; Tankyrase-2 (TANK2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-like protein) (Tankyrase-related protein) TNKS2 PARP5B TANK2 TNKL Homo sapiens (Human) TR23187_c2_g1_i1 Q6PCN7 HLTF_MOUSE 2.00E-90 GO:0005524; GO:0016887; GO:0003677; GO:0016568; GO:0005737; GO:0004386; GO:0016874; GO:0005730; GO:0005654; GO:0016567; GO:0006357; GO:0006351; GO:0008270 "ATP binding; ATPase activity; DNA binding; chromatin modification; cytoplasm; helicase activity; ligase activity; nucleolus; nucleoplasm; protein ubiquitination; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; zinc ion binding" IPR014001; IPR001650; IPR014905; IPR027417; IPR000330; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Helicase-like transcription factor (EC 3.6.4.-) (EC 6.3.2.-) (P113) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) (TNF-response element-binding protein) Hltf Smarca3 Snf2l3 Zbu1 Mus musculus (Mouse) TR23190_c0_g1_i1 P18172 DHGL_DROPS 4.00E-35 GO:0006066; GO:0008812; GO:0005576; GO:0050660 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR23191_c0_g1_i1 A7YWP4 HUTH_BOVIN 4.00E-94 GO:0009058; GO:0005737; GO:0004397; GO:0019556; GO:0019557 biosynthetic process; cytoplasm; histidine ammonia-lyase activity; histidine catabolic process to glutamate and formamide; histidine catabolic process to glutamate and formate IPR001106; IPR024083; IPR005921; IPR008948; IPR022313; Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3. Histidine ammonia-lyase (Histidase) (EC 4.3.1.3) HAL Bos taurus (Bovine) TR23193_c1_g1_i1 Q8K3Z0 NOD2_MOUSE 4.00E-07 GO:0005524; GO:0050700; GO:0035419; GO:0009986; GO:0071224; GO:0002367; GO:0005829; GO:0050830; GO:0016045; GO:0032498; GO:0016888; GO:0002381; GO:0006954; GO:0002227; GO:0071608; GO:0032500; GO:0032088; GO:0002710; GO:0044130; GO:0002862; GO:0032689; GO:0032695; GO:0032701; GO:0032703; GO:2000110; GO:0034136; GO:0032720; GO:0070431; GO:0042834; GO:0005886; GO:0070374; GO:0043123; GO:0046330; GO:0051092; GO:0045747; GO:0006965; GO:0002606; GO:0050679; GO:0002925; GO:0050718; GO:0032733; GO:0032735; GO:0032740; GO:0032755; GO:0051770; GO:0050731; GO:0050766; GO:0043552; GO:2000363; GO:0060585; GO:0031398; GO:0032760; GO:0002830; GO:0019901; GO:0051259; GO:0090022; GO:0043330; GO:0032496; GO:0031982 "ATP binding; CARD domain binding; activation of MAPK activity involved in innate immune response; cell surface; cellular response to peptidoglycan; cytokine production involved in immune response; cytosol; defense response to Gram-positive bacterium; detection of bacterium; detection of muramyl dipeptide; endodeoxyribonuclease activity, producing 5'-phosphomonoesters; immunoglobulin production involved in immunoglobulin mediated immune response; inflammatory response; innate immune response in mucosa; macrophage inflammatory protein-1 alpha production; muramyl dipeptide binding; negative regulation of NF-kappaB transcription factor activity; negative regulation of T cell mediated immunity; negative regulation of growth of symbiont in host; negative regulation of inflammatory response to antigenic stimulus; negative regulation of interferon-gamma production; negative regulation of interleukin-12 production; negative regulation of interleukin-18 production; negative regulation of interleukin-2 production; negative regulation of macrophage apoptotic process; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of tumor necrosis factor production; nucleotide-binding oligomerization domain containing 2 signaling pathway; peptidoglycan binding; plasma membrane; positive regulation of ERK1 and ERK2 cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of Notch signaling pathway; positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria; positive regulation of dendritic cell antigen processing and presentation; positive regulation of epithelial cell proliferation; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-17 production; positive regulation of interleukin-6 production; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phagocytosis; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of prostaglandin-E synthase activity; positive regulation of prostaglandin-endoperoxide synthase activity; positive regulation of protein ubiquitination; positive regulation of tumor necrosis factor production; positive regulation of type 2 immune response; protein kinase binding; protein oligomerization; regulation of neutrophil chemotaxis; response to exogenous dsRNA; response to lipopolysaccharide; vesicle" IPR001315; IPR011029; IPR018228; IPR007111; IPR027417; Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) Nod2 Card15 Mus musculus (Mouse) TR23193_c1_g2_i1 A0JPI9 CN16B_RAT 4.00E-24 Uncharacterized protein C14orf166B homolog Rattus norvegicus (Rat) TR23194_c1_g1_i1 Q9PVW8 SAL_SILAS 7.00E-15 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR000922; Rhamnose-binding lectin (RBL) (Roe lectin) (SAL) Silurus asotus (Amur catfish) (Parasilurus asotus) TR232_c0_g1_i1 Q8N6D5 ANR29_HUMAN 3.00E-23 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 29 ANKRD29 Homo sapiens (Human) TR232_c0_g2_i1 Q9QZH2 BARD1_RAT 2.00E-10 GO:0031436; GO:0006281; GO:0005737; GO:0016874; GO:0043066; GO:0046826; GO:0043065; GO:0085020; GO:0042803; GO:0042325; GO:0007283; GO:0008270 BRCA1-BARD1 complex; DNA repair; cytoplasm; ligase activity; negative regulation of apoptotic process; negative regulation of protein export from nucleus; positive regulation of apoptotic process; protein K6-linked ubiquitination; protein homodimerization activity; regulation of phosphorylation; spermatogenesis; zinc ion binding IPR002110; IPR020683; IPR001357; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. BRCA1-associated RING domain protein 1 (BARD-1) (EC 6.3.2.-) Bard1 Rattus norvegicus (Rat) TR23201_c0_g1_i1 P78774 ARPC1_SCHPO 1.00E-51 GO:0034314; GO:0005885; GO:0030479; GO:0000147; GO:0032153; GO:0051286; GO:0005829; GO:0006897; GO:0000281 Arp2/3 complex-mediated actin nucleation; Arp2/3 protein complex; actin cortical patch; actin cortical patch assembly; cell division site; cell tip; cytosol; endocytosis; mitotic cytokinesis IPR017383; IPR015943; IPR001680; IPR017986; Actin-related protein 2/3 complex subunit 1 (Arp2/3 complex 41 kDa subunit) (p41-ARC) arc1 sop2 SPBC14C8.06 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR23201_c2_g1_i1 Q92747 ARC1A_HUMAN 2.00E-79 GO:0038096; GO:0003779; GO:0015629; GO:0030036; GO:0005829; GO:0045087; GO:0030833 Fc-gamma receptor signaling pathway involved in phagocytosis; actin binding; actin cytoskeleton; actin cytoskeleton organization; cytosol; innate immune response; regulation of actin filament polymerization IPR017383; IPR015943; IPR001680; IPR017986; Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) ARPC1A SOP2L Homo sapiens (Human) TR23207_c0_g1_i1 P82596 PLC_HALLA 1.00E-29 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR23209_c0_g1_i1 Q32P51 RA1L2_HUMAN 6.00E-23 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0051028; GO:0000166; GO:0005681 RNA binding; RNA splicing; cytoplasm; mRNA processing; mRNA transport; nucleotide binding; spliceosomal complex IPR021662; IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2) HNRNPA1L2 HNRNPA1L Homo sapiens (Human) TR23209_c0_g1_i2 Q99020 ROAA_MOUSE 9.00E-46 GO:0003677; GO:0003723; GO:0005737; GO:0001837; GO:0000166; GO:0005634; GO:0045893; GO:0030529; GO:0006351 "DNA binding; RNA binding; cytoplasm; epithelial to mesenchymal transition; nucleotide binding; nucleus; positive regulation of transcription, DNA-dependent; ribonucleoprotein complex; transcription, DNA-dependent" IPR012956; IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A) Hnrnpab Cbf-a Cgbfa Hnrpab Mus musculus (Mouse) TR23209_c1_g1_i1 Q6GPV5 RN181_XENLA 1.00E-06 GO:0016874; GO:0016567; GO:0008270 ligase activity; protein ubiquitination; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF181 (EC 6.3.2.-) (RING finger protein 181) rnf181 Xenopus laevis (African clawed frog) TR23214_c0_g1_i1 Q5M7G4 KAD8_XENLA 8.00E-180 GO:0005524; GO:0004017; GO:0004127; GO:0005829; GO:0004550; GO:0009142 ATP binding; adenylate kinase activity; cytidylate kinase activity; cytosol; nucleoside diphosphate kinase activity; nucleoside triphosphate biosynthetic process IPR000850; IPR003117; IPR027417; Adenylate kinase 8 (AK 8) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 8) ak8 Xenopus laevis (African clawed frog) TR23224_c0_g1_i1 P43395 ATPBM_ACTDE 8.00E-76 GO:0005524; GO:0015991; GO:0015986; GO:0005743; GO:0046933; GO:0045261 "ATP binding; ATP hydrolysis coupled proton transport; ATP synthesis coupled proton transport; mitochondrial inner membrane; proton-transporting ATP synthase activity, rotational mechanism; proton-transporting ATP synthase complex, catalytic core F(1)" IPR020003; IPR005722; IPR000793; IPR000194; IPR024034; IPR027417; "ATP synthase subunit beta, mitochondrial (EC 3.6.3.14) (Fragment)" ATPB pKIWI505 Actinidia deliciosa (Kiwi) TR23224_c1_g1_i1 Q25117 ATPB_HEMPU 0 GO:0005524; GO:0015991; GO:0015986; GO:0005743; GO:0046933; GO:0045261 "ATP binding; ATP hydrolysis coupled proton transport; ATP synthesis coupled proton transport; mitochondrial inner membrane; proton-transporting ATP synthase activity, rotational mechanism; proton-transporting ATP synthase complex, catalytic core F(1)" IPR003593; IPR020003; IPR005722; IPR000793; IPR000194; IPR004100; IPR024034; IPR027417; "ATP synthase subunit beta, mitochondrial (EC 3.6.3.14)" Hemicentrotus pulcherrimus (Sea urchin) (Strongylocentrotus pulcherrimus) TR23225_c3_g1_i1 Q32L96 PHIPL_BOVIN 7.00E-26 GO:0005737 cytoplasm IPR003961; IPR013783; Phytanoyl-CoA hydroxylase interacting protein-like PHYHIPL Bos taurus (Bovine) TR23226_c1_g1_i1 Q10751 ACE_CHICK 1.00E-63 GO:0004180; GO:0016021; GO:0046872; GO:0008237; GO:0008241; GO:0006508 carboxypeptidase activity; integral to membrane; metal ion binding; metallopeptidase activity; peptidyl-dipeptidase activity; proteolysis IPR001548; Angiotensin-converting enzyme (ACE) (EC 3.2.1.-) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (Fragment) ACE DCP1 Gallus gallus (Chicken) TR23229_c0_g1_i1 Q6P823 H33_XENTR 2.00E-90 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR000164; Histone H3.3 TGas113e22.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR23235_c0_g2_i1 Q9VUL9 FUCTA_DROME 4.00E-31 GO:0033932; GO:0032580; GO:0005797; GO:0036071; GO:0018392; GO:0016021; GO:0007399; GO:0006486 Q9VG62 "1,3-alpha-L-fucosidase activity; Golgi cisterna membrane; Golgi medial cisterna; N-glycan fucosylation; glycoprotein 3-alpha-L-fucosyltransferase activity; integral to membrane; nervous system development; protein glycosylation" IPR001503; Protein modification; protein glycosylation. "Glycoprotein 3-alpha-L-fucosyltransferase A (EC 2.4.1.214) (Core alpha-(1,3)-fucosyltransferase)" FucTA CG6869 Drosophila melanogaster (Fruit fly) TR23246_c1_g1_i1 Q3UVD5 LGR6_MOUSE 2.00E-08 GO:0016055; GO:0016021; GO:0005886; GO:0016500 Wnt receptor signaling pathway; integral to membrane; plasma membrane; protein-hormone receptor activity IPR000276; IPR002131; IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing G-protein coupled receptor 6 Lgr6 Mus musculus (Mouse) TR23249_c0_g1_i1 P53677 AP3M2_HUMAN 2.00E-115 GO:0030119; GO:0005794; GO:0008089; GO:0048490; GO:0030131; GO:0006886 AP-type membrane coat adaptor complex; Golgi apparatus; anterograde axon cargo transport; anterograde synaptic vesicle transport; clathrin adaptor complex; intracellular protein transport IPR022775; IPR001392; IPR008968; IPR018240; IPR011012; AP-3 complex subunit mu-2 (Adapter-related protein complex 3 subunit mu-2) (Clathrin assembly protein assembly protein complex 3 mu-2 medium chain) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Mu3B-adaptin) (P47B) AP3M2 Homo sapiens (Human) TR23249_c0_g2_i1 Q3SYW1 AP1M2_BOVIN 5.00E-23 GO:0005794; GO:0030131; GO:0030665; GO:0006886; GO:0016192 Golgi apparatus; clathrin adaptor complex; clathrin-coated vesicle membrane; intracellular protein transport; vesicle-mediated transport IPR022775; IPR001392; IPR008968; IPR018240; IPR011012; AP-1 complex subunit mu-2 (AP-mu chain family member mu1B) (Adaptor protein complex AP-1 subunit mu-2) (Adaptor-related protein complex 1 subunit mu-2) (Clathrin assembly protein complex 1 mu-2 medium chain 2) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Mu-adaptin 2) (Mu1B-adaptin) AP1M2 Bos taurus (Bovine) TR23250_c0_g1_i1 P04069 CBPB_ASTFL 4.00E-70 GO:0005576; GO:0004181; GO:0006508; GO:0008270 extracellular region; metallocarboxypeptidase activity; proteolysis; zinc ion binding IPR000834; Carboxypeptidase B (EC 3.4.17.2) Astacus astacus (Noble crayfish) (Astacus fluviatilis) TR23255_c0_g1_i1 P22974 H1L_MYTCA 2.00E-29 GO:0003677; GO:0030154; GO:0030261; GO:0007275; GO:0000786; GO:0006334; GO:0005634; GO:0007283 DNA binding; cell differentiation; chromosome condensation; multicellular organismal development; nucleosome; nucleosome assembly; nucleus; spermatogenesis IPR005818; IPR005819; IPR011991; Sperm-specific protein PHI-2B (PL-II*) (Sperm-specific linker histone H1-like protein) Mytilus californianus (California mussel) TR23257_c0_g1_i1 O43581 SYT7_HUMAN 2.00E-85 GO:0005509; GO:0030054; GO:0016021; GO:0005764; GO:0005886; GO:0001778; GO:0017158; GO:0050796; GO:0030672; GO:0005215 calcium ion binding; cell junction; integral to membrane; lysosome; plasma membrane; plasma membrane repair; regulation of calcium ion-dependent exocytosis; regulation of insulin secretion; synaptic vesicle membrane; transporter activity IPR000008; IPR001565; IPR015427; Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII) SYT7 PCANAP7 Homo sapiens (Human) TR23259_c2_g1_i1 Q61409 PDE3B_MOUSE 3.00E-34 GO:0004114; GO:0005794; GO:0001525; GO:0032869; GO:0005829; GO:0031018; GO:0005783; GO:0042593; GO:0016021; GO:0016020; GO:0008152; GO:0046872; GO:0016525; GO:0050796; GO:0007165 "3',5'-cyclic-nucleotide phosphodiesterase activity; Golgi apparatus; angiogenesis; cellular response to insulin stimulus; cytosol; endocrine pancreas development; endoplasmic reticulum; glucose homeostasis; integral to membrane; membrane; metabolic process; metal ion binding; negative regulation of angiogenesis; regulation of insulin secretion; signal transduction" IPR003607; IPR002073; IPR023174; "cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (CGIPDE1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B)" Pde3b Mus musculus (Mouse) TR23259_c2_g2_i1 O60658 PDE8A_HUMAN 7.00E-136 GO:0004115; GO:0004114; GO:0006198; GO:0009187; GO:0005829; GO:0035556; GO:0046872; GO:0000156; GO:0006355 "3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cAMP catabolic process; cyclic nucleotide metabolic process; cytosol; intracellular signal transduction; metal ion binding; phosphorelay response regulator activity; regulation of transcription, DNA-dependent" IPR003607; IPR000014; IPR013767; IPR023088; IPR002073; IPR023174; IPR001789; "Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1." "High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53)" PDE8A Homo sapiens (Human) TR23259_c4_g1_i1 E9Q4S1 PDE8B_MOUSE 2.00E-77 GO:0004114; GO:0006198; GO:0035556; GO:0046872; GO:0000156; GO:0006355 "3',5'-cyclic-nucleotide phosphodiesterase activity; cAMP catabolic process; intracellular signal transduction; metal ion binding; phosphorelay response regulator activity; regulation of transcription, DNA-dependent" IPR003607; IPR000014; IPR023088; IPR002073; IPR023174; IPR013938; IPR001789; "Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1." "High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B) (EC 3.1.4.53) (Cell proliferation-inducing gene 22 protein)" Pde8b Mus musculus (Mouse) TR23264_c2_g1_i1 Q18297 TRPA1_CAEEL 3.00E-31 GO:0016021; GO:0005216; GO:0043025; GO:0031513; GO:0050896 integral to membrane; ion channel activity; neuronal cell body; nonmotile primary cilium; response to stimulus IPR002110; IPR020683; IPR005821; Transient receptor potential cation channel subfamily A member 1 homolog trpa-1 C29E6.2 Caenorhabditis elegans TR23268_c0_g1_i1 O95279 KCNK5_HUMAN 2.00E-12 GO:0007588; GO:0005887; GO:0005267; GO:0005244 excretion; integral to plasma membrane; potassium channel activity; voltage-gated ion channel activity IPR003280; IPR013099; IPR003092; Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2) KCNK5 TASK2 Homo sapiens (Human) TR23274_c2_g2_i1 O42329 GNRR2_CLAGA 5.00E-17 GO:0097211; GO:0004968; GO:0016021; GO:0005886 cellular response to gonadotropin-releasing hormone; gonadotropin-releasing hormone receptor activity; integral to membrane; plasma membrane IPR000276; IPR017452; IPR027983; IPR001658; Gonadotropin-releasing hormone II receptor (GnRH II receptor) (GnRH-II-R) (Type II GnRH receptor) Clarias gariepinus (African sharptooth catfish) (North African catfish) TR23278_c1_g1_i1 O05394 MCCB_BACSU 2.00E-88 GO:0080146; GO:0044540; GO:0004123; GO:0047982; GO:0008152; GO:0030170 L-cysteine desulfhydrase activity; L-cystine L-cysteine-lyase (deaminating); cystathionine gamma-lyase activity; homocysteine desulfhydrase activity; metabolic process; pyridoxal phosphate binding IPR000277; IPR015424; IPR015421; IPR015422; Cystathionine gamma-lyase (EC 4.4.1.1) (Gamma-cystathionase) (Homocysteine gamma-lyase) (EC 4.4.1.2) mccB yrhB BSU27250 Bacillus subtilis (strain 168) TR23279_c1_g2_i1 Q63734 KCNC4_RAT 5.00E-14 GO:0051260; GO:0005249; GO:0008076 protein homooligomerization; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR005405; IPR021105; IPR003131; IPR028325; Potassium voltage-gated channel subfamily C member 4 (Raw3) (Voltage-gated potassium channel subunit Kv3.4) Kcnc4 Rattus norvegicus (Rat) TR23280_c1_g1_i2 Q8BU91 S26A9_MOUSE 2.00E-06 GO:0015301; GO:0016324; GO:0015106; GO:0006821; GO:0016021; GO:0006885; GO:0008271; GO:0008272 anion:anion antiporter activity; apical plasma membrane; bicarbonate transmembrane transporter activity; chloride transport; integral to membrane; regulation of pH; secondary active sulfate transmembrane transporter activity; sulfate transport IPR002645; IPR001902; IPR011547; Solute carrier family 26 member 9 (Anion transporter/exchanger protein 9) Slc26a9 Mus musculus (Mouse) TR23280_c1_g2_i1 O70531 S26A2_RAT 7.00E-06 GO:0016021; GO:0001503; GO:0008271; GO:0015116; GO:0008272 integral to membrane; ossification; secondary active sulfate transmembrane transporter activity; sulfate transmembrane transporter activity; sulfate transport IPR018045; IPR002645; IPR001902; IPR011547; Sulfate transporter (Diastrophic dysplasia protein homolog) (Solute carrier family 26 member 2) Slc26a2 Dtdst Rattus norvegicus (Rat) TR23285_c0_g1_i1 Q9QZM9 FBX16_MOUSE 6.00E-07 IPR001810; F-box only protein 16 Fbxo16 Fbx16 Mus musculus (Mouse) TR23285_c2_g2_i1 Q8VBV4 FBXW7_MOUSE 5.00E-24 GO:0005794; GO:0007219; GO:0019005; GO:0031146; GO:0005783; GO:0030324; GO:0005634; GO:0048471; GO:0016567; GO:0003700; GO:0001570 Golgi apparatus; Notch signaling pathway; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; endoplasmic reticulum; lung development; nucleus; perinuclear region of cytoplasm; protein ubiquitination; sequence-specific DNA binding transcription factor activity; vasculogenesis IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10) Fbxw7 Fbw7 Fbwd6 Fbxw6 Mus musculus (Mouse) TR23294_c0_g1_i1 Q3BCR6 TPMT_HORSE 1.00E-10 GO:0005737; GO:0008119 cytoplasm; thiopurine S-methyltransferase activity IPR025835; IPR008854; Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) TPMT Equus caballus (Horse) TR23303_c0_g1_i1 P16257 TSPO_RAT 2.00E-46 GO:0030325; GO:0007568; GO:0005497; GO:0048266; GO:0008503; GO:0071476; GO:0071222; GO:0071294; GO:0006821; GO:0060242; GO:0008347; GO:0016021; GO:0005741; GO:0060253; GO:0045019; GO:0032720; GO:0014012; GO:0043065; GO:0051928; GO:0060252; GO:0051901; GO:0010940; GO:2000379; GO:0050810; GO:0042493; GO:0010042; GO:0032570; GO:0033574; GO:0010266; GO:0006694 adrenal gland development; aging; androgen binding; behavioral response to pain; benzodiazepine receptor activity; cellular hypotonic response; cellular response to lipopolysaccharide; cellular response to zinc ion; chloride transport; contact inhibition; glial cell migration; integral to membrane; mitochondrial outer membrane; negative regulation of glial cell proliferation; negative regulation of nitric oxide biosynthetic process; negative regulation of tumor necrosis factor production; peripheral nervous system axon regeneration; positive regulation of apoptotic process; positive regulation of calcium ion transport; positive regulation of glial cell proliferation; positive regulation of mitochondrial depolarization; positive regulation of necrotic cell death; positive regulation of reactive oxygen species metabolic process; regulation of steroid biosynthetic process; response to drug; response to manganese ion; response to progesterone stimulus; response to testosterone stimulus; response to vitamin B1; steroid biosynthetic process IPR004307; Translocator protein (Mitochondrial benzodiazepine receptor) (PKBS) (Peripheral-type benzodiazepine receptor) (PBR) Tspo Bzrp Mbr Rattus norvegicus (Rat) TR23308_c0_g1_i1 Q8WV16 DCAF4_HUMAN 7.00E-36 GO:0080008; GO:0016567 Cul4-RING ubiquitin ligase complex; protein ubiquitination IPR015943; IPR001680; IPR017986; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 4 (WD repeat-containing protein 21A) DCAF4 WDR21 WDR21A Homo sapiens (Human) TR23311_c3_g1_i1 Q11131 FUT7_MOUSE 9.00E-16 GO:0002361; GO:0032580; GO:0036065; GO:0008417; GO:0016021; GO:0002522; GO:0006486 "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; Golgi cisterna membrane; fucosylation; fucosyltransferase activity; integral to membrane; leukocyte migration involved in immune response; protein glycosylation" IPR001503; Protein modification; protein glycosylation. "Alpha-(1,3)-fucosyltransferase 7 (EC 2.4.1.-) (Fucosyltransferase 7) (Fucosyltransferase VII) (Fuc-TVII) (FucT-VII) (Galactoside 3-L-fucosyltransferase)" Fut7 Mus musculus (Mouse) TR23311_c8_g1_i1 P83088 FUCTC_DROME 3.00E-19 GO:0032580; GO:0036065; GO:0008417; GO:0016021; GO:0006486 Golgi cisterna membrane; fucosylation; fucosyltransferase activity; integral to membrane; protein glycosylation IPR001503; Protein modification; protein glycosylation. "Alpha-(1,3)-fucosyltransferase C (EC 2.4.1.-) (Galactoside 3-L-fucosyltransferase)" FucTC CG40305 Drosophila melanogaster (Fruit fly) TR23311_c8_g2_i1 Q11127 FUT4_MOUSE 5.00E-09 GO:0032580; GO:0071944; GO:0009986; GO:0036065; GO:0008417; GO:0016021; GO:0006486 Golgi cisterna membrane; cell periphery; cell surface; fucosylation; fucosyltransferase activity; integral to membrane; protein glycosylation IPR001503; Protein modification; protein glycosylation. "Alpha-(1,3)-fucosyltransferase 4 (EC 2.4.1.-) (Fucosyltransferase 4) (Fucosyltransferase IV) (Fuc-TIV) (FucT-IV) (Galactoside 3-L-fucosyltransferase)" Fut4 Elft Mus musculus (Mouse) TR23313_c1_g1_i2 Q04202 TCB2_CAEBR 1.00E-18 GO:0003677; GO:0015074; GO:0005634; GO:0004803; GO:0006313 "DNA binding; DNA integration; nucleus; transposase activity; transposition, DNA-mediated" IPR002492; Transposable element Tcb2 transposase Caenorhabditis briggsae TR23314_c0_g1_i2 Q3MHV6 SLAI2_BOVIN 3.00E-08 GO:0005813; GO:0005737; GO:0031122; GO:0015630; GO:0007020; GO:0035371; GO:0031116 centrosome; cytoplasm; cytoplasmic microtubule organization; microtubule cytoskeleton; microtubule nucleation; microtubule plus end; positive regulation of microtubule polymerization IPR026179; SLAIN motif-containing protein 2 SLAIN2 Bos taurus (Bovine) TR23317_c1_g1_i1 P39806 SALM_DROVI 7.00E-11 GO:0003677; GO:0046872; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Homeotic protein spalt-major salm Drosophila virilis (Fruit fly) TR23317_c3_g1_i1 P10073 ZSC22_HUMAN 3.00E-28 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 22 (Krueppel-related zinc finger protein 2) (Protein HKR2) (Zinc finger protein 50) ZSCAN22 HKR2 ZNF50 Homo sapiens (Human) TR23323_c0_g1_i1 Q28IK8 MARH8_XENTR 8.00E-08 GO:0030659; GO:0031901; GO:0005768; GO:0016021; GO:0005765; GO:0005764; GO:0004842; GO:0008270 cytoplasmic vesicle membrane; early endosome membrane; endosome; integral to membrane; lysosomal membrane; lysosome; ubiquitin-protein ligase activity; zinc ion binding IPR011016; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MARCH8 (EC 6.3.2.-) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (MARCH-VIII) march8 TNeu072c23.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR23333_c0_g1_i1 Q3SZZ7 FGL1_BOVIN 2.00E-15 GO:0005576 extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein 1 FGL1 Bos taurus (Bovine) TR23333_c0_g2_i1 Q29041 FCN2_PIG 3.00E-26 GO:0005581; GO:0001867 "collagen; complement activation, lectin pathway" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) FCN2 Sus scrofa (Pig) TR23335_c3_g2_i1 Q8C8H8 KY_MOUSE 1.00E-07 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) TR23340_c1_g1_i1 A4D263 CG072_HUMAN 4.00E-25 IPR027867; Uncharacterized protein C7orf72 C7orf72 Homo sapiens (Human) TR23345_c0_g4_i1 A0B5E6 RS15_METTP 2.00E-22 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR012606; IPR000589; IPR023029; IPR009068; 30S ribosomal protein S15 rps15 Mthe_0120 Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT)) TR23345_c0_g5_i1 P62278 RS13_RAT 2.00E-98 GO:0022627; GO:0003735; GO:0006412 cytosolic small ribosomal subunit; structural constituent of ribosome; translation IPR012606; IPR000589; IPR023029; IPR009068; 40S ribosomal protein S13 Rps13 Rattus norvegicus (Rat) TR23352_c0_g1_i1 Q06136 KDSR_HUMAN 5.00E-108 GO:0047560; GO:0006666; GO:0005789; GO:0005615; GO:0016021; GO:0030148 3-dehydrosphinganine reductase activity; 3-keto-sphinganine metabolic process; endoplasmic reticulum membrane; extracellular space; integral to membrane; sphingolipid biosynthetic process IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; sphingolipid metabolism. 3-ketodihydrosphingosine reductase (KDS reductase) (EC 1.1.1.102) (3-dehydrosphinganine reductase) (Follicular variant translocation protein 1) (FVT-1) KDSR FVT1 Homo sapiens (Human) TR23358_c0_g1_i1 P13608 PGCA_BOVIN 6.00E-08 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 Q9UNA0; P49747 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Bos taurus (Bovine) TR23358_c0_g2_i1 Q9NQ36 SCUB2_HUMAN 5.00E-10 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR026823; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR011641; "Signal peptide, CUB and EGF-like domain-containing protein 2 (Protein CEGP1)" SCUBE2 CEGP1 Homo sapiens (Human) TR23358_c3_g1_i1 O35516 NOTC2_MOUSE 7.00E-42 GO:0007219; GO:0060413; GO:0005509; GO:0007050; GO:0001709; GO:0016049; GO:0009986; GO:0061073; GO:0005829; GO:0030326; GO:0005576; GO:0072104; GO:0072015; GO:0001947; GO:0006959; GO:0001701; GO:0002437; GO:0005887; GO:0072602; GO:0070986; GO:0002011; GO:0008285; GO:0000122; GO:0005654; GO:0060674; GO:0030513; GO:0046579; GO:0043065; GO:0008284; GO:0045672; GO:0072014; GO:0006351; GO:0042060 "Notch signaling pathway; atrial septum morphogenesis; calcium ion binding; cell cycle arrest; cell fate determination; cell growth; cell surface; ciliary body morphogenesis; cytosol; embryonic limb morphogenesis; extracellular region; glomerular capillary formation; glomerular visceral epithelial cell development; heart looping; humoral immune response; in utero embryonic development; inflammatory response to antigenic stimulus; integral to plasma membrane; interleukin-4 secretion; left/right axis specification; morphogenesis of an epithelial sheet; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; placenta blood vessel development; positive regulation of BMP signaling pathway; positive regulation of Ras protein signal transduction; positive regulation of apoptotic process; positive regulation of cell proliferation; positive regulation of osteoclast differentiation; proximal tubule development; transcription, DNA-dependent; wound healing" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022336; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 2 (Notch 2) (Motch B) [Cleaved into: Notch 2 extracellular truncation; Notch 2 intracellular domain] Notch2 Mus musculus (Mouse) TR23358_c4_g2_i1 P49013 FBP3_STRPU 2.00E-39 GO:0005509; GO:0005615 calcium ion binding; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) TR23358_c5_g1_i1 Q6AZ60 EGFL7_RAT 2.00E-08 GO:0001525; GO:0005509; GO:0005576; GO:0001570 angiogenesis; calcium ion binding; extracellular region; vasculogenesis IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR013111; IPR011489; Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) Egfl7 Cbl20 Megf7 Rattus norvegicus (Rat) TR23359_c1_g1_i1 Q504Y3 ZCPW2_HUMAN 1.00E-07 GO:0008270 zinc ion binding IPR000313; IPR011124; Zinc finger CW-type PWWP domain protein 2 ZCWPW2 Homo sapiens (Human) TR23363_c1_g1_i1 Q66D54 BETA_YERPS 7.00E-08 GO:0008802; GO:0008812; GO:0050660; GO:0019285 betaine-aldehyde dehydrogenase activity; choline dehydrogenase activity; flavin adenine dinucleotide binding; glycine betaine biosynthetic process from choline IPR011533; IPR012132; IPR000172; IPR007867; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. Oxygen-dependent choline dehydrogenase (CDH) (CHD) (EC 1.1.99.1) (Betaine aldehyde dehydrogenase) (BADH) (EC 1.2.1.8) betA YPTB1195 Yersinia pseudotuberculosis serotype I (strain IP32953) TR23367_c0_g1_i1 P13608 PGCA_BOVIN 7.00E-16 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 Q9UNA0; P49747 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Bos taurus (Bovine) TR23367_c0_g2_i1 P86854 PLCL_MYTGA 1.00E-20 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR23373_c0_g1_i1 Q9NTG1 PKDRE_HUMAN 6.00E-09 GO:0007340; GO:0005262; GO:0005509; GO:0050982; GO:0016021; GO:0016020; GO:0007218; GO:0005886; GO:0060046 acrosome reaction; calcium channel activity; calcium ion binding; detection of mechanical stimulus; integral to membrane; membrane; neuropeptide signaling pathway; plasma membrane; regulation of acrosome reaction IPR000203; IPR008976; IPR002859; IPR013122; IPR003915; IPR001024; IPR014010; Polycystic kidney disease and receptor for egg jelly-related protein (PKD and REJ homolog) PKDREJ Homo sapiens (Human) TR23373_c0_g1_i2 Q9NTG1 PKDRE_HUMAN 2.00E-08 GO:0007340; GO:0005262; GO:0005509; GO:0050982; GO:0016021; GO:0016020; GO:0007218; GO:0005886; GO:0060046 acrosome reaction; calcium channel activity; calcium ion binding; detection of mechanical stimulus; integral to membrane; membrane; neuropeptide signaling pathway; plasma membrane; regulation of acrosome reaction IPR000203; IPR008976; IPR002859; IPR013122; IPR003915; IPR001024; IPR014010; Polycystic kidney disease and receptor for egg jelly-related protein (PKD and REJ homolog) PKDREJ Homo sapiens (Human) TR23373_c0_g2_i1 Q4GZT3 PKD2_BOVIN 8.00E-28 GO:0007259; GO:0035904; GO:0045180; GO:0009925; GO:0001658; GO:0005262; GO:0005509; GO:0048763; GO:0007050; GO:0005911; GO:0071498; GO:0071464; GO:0071470; GO:0042994; GO:0050982; GO:0003127; GO:0071910; GO:0001892; GO:0031941; GO:0001947; GO:0071458; GO:0071556; GO:0005887; GO:0030027; GO:0016020; GO:0072177; GO:0072284; GO:0072218; GO:0072214; GO:0072219; GO:0072235; GO:0072075; GO:0035502; GO:0072208; GO:0005932; GO:0072686; GO:0031512; GO:2000134; GO:0060315; GO:0021915; GO:0031513; GO:0060674; GO:0002133; GO:0071158; GO:0031659; GO:0031587; GO:0045429; GO:0045944; GO:0005267; GO:0030814; GO:0090279; GO:0042127; GO:0051209; GO:0061441; GO:0061333; GO:0021510; GO:0005245; GO:0005248 "JAK-STAT cascade; aorta development; basal cortex; basal plasma membrane; branching involved in ureteric bud morphogenesis; calcium channel activity; calcium ion binding; calcium-induced calcium release activity; cell cycle arrest; cell-cell junction; cellular response to fluid shear stress; cellular response to hydrostatic pressure; cellular response to osmotic stress; cytoplasmic sequestering of transcription factor; detection of mechanical stimulus; detection of nodal flow; determination of liver left/right asymmetry; embryonic placenta development; filamentous actin; heart looping; integral to cytosolic side of endoplasmic reticulum membrane; integral to lumenal side of endoplasmic reticulum membrane; integral to plasma membrane; lamellipodium; membrane; mesonephric duct development; metanephric S-shaped body morphogenesis; metanephric ascending thin limb development; metanephric cortex development; metanephric cortical collecting duct development; metanephric distal tubule development; metanephric mesenchyme development; metanephric part of ureteric bud development; metanephric smooth muscle tissue development; microtubule basal body; mitotic spindle; motile primary cilium; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of ryanodine-sensitive calcium-release channel activity; neural tube development; nonmotile primary cilium; placenta blood vessel development; polycystin complex; positive regulation of cell cycle arrest; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; positive regulation of nitric oxide biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; potassium channel activity; regulation of cAMP metabolic process; regulation of calcium ion import; regulation of cell proliferation; release of sequestered calcium ion into cytosol; renal artery morphogenesis; renal tubule morphogenesis; spinal cord development; voltage-gated calcium channel activity; voltage-gated sodium channel activity" IPR027359; IPR011992; IPR002048; IPR013122; IPR003915; Polycystin-2 (Polycystic kidney disease 2 protein homolog) PKD2 Bos taurus (Bovine) TR23373_c1_g1_i1 Q9U1S7 PKD2_CAEEL 1.00E-11 GO:0030424; GO:0005262; GO:0005509; GO:0060170; GO:0030425; GO:0050982; GO:0005783; GO:0005789; GO:0016021; GO:0043025; GO:0031513; GO:0043204; GO:0048471; GO:0034606; GO:0034608 axon; calcium channel activity; calcium ion binding; cilium membrane; dendrite; detection of mechanical stimulus; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; neuronal cell body; nonmotile primary cilium; perikaryon; perinuclear region of cytoplasm; response to hermaphrodite contact; vulval location IPR013122; IPR003915; Polycystin-2 (CePc2) (Polycystic kidney disease 2 protein homolog) pkd-2 Y73F8A.1 Caenorhabditis elegans TR23374_c1_g1_i1 Q5BJE1 CR034_HUMAN 5.00E-08 Coiled-coil domain-containing protein 178 CCDC178 C18orf34 Homo sapiens (Human) TR23382_c0_g1_i1 Q9R1R2 TRIM3_MOUSE 1.00E-12 GO:0005737; GO:0005769; GO:0015031; GO:0008270 cytoplasm; early endosome; protein transport; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) TR23389_c2_g1_i1 Q9P209 CEP72_HUMAN 4.00E-18 GO:0000086; GO:0005813; GO:0005829; GO:0033566; GO:0007051 O15265; Q2M2Z5 G2/M transition of mitotic cell cycle; centrosome; cytosol; gamma-tubulin complex localization; spindle organization IPR001611; IPR025875; IPR003603; Centrosomal protein of 72 kDa (Cep72) CEP72 KIAA1519 Homo sapiens (Human) TR2339_c0_g1_i1 P35953 VLDLR_RABIT 6.00E-17 GO:0005509; GO:0008203; GO:0005905; GO:0034436; GO:0034437; GO:0016021; GO:0006869; GO:0000122; GO:1900006; GO:0038025; GO:0021517; GO:0034361; GO:0034189; GO:0034447; GO:0030229 calcium ion binding; cholesterol metabolic process; coated pit; glycoprotein transport; glycoprotein transporter activity; integral to membrane; lipid transport; negative regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite development; reelin receptor activity; ventral spinal cord development; very-low-density lipoprotein particle; very-low-density lipoprotein particle binding; very-low-density lipoprotein particle clearance; very-low-density lipoprotein particle receptor activity IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) VLDLR Oryctolagus cuniculus (Rabbit) TR23397_c0_g1_i1 Q7K237 C1GLT_DROME 3.00E-129 GO:0016267; GO:0021551; GO:0009247; GO:0016263; GO:0016021; GO:0046872 "O-glycan processing, core 1; central nervous system morphogenesis; glycolipid biosynthetic process; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity; integral to membrane; metal ion binding" IPR026842; IPR003378; Protein modification; protein glycosylation. "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (Core 1 O-glycan T-synthase) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1)" C1GalTA CG9520 Drosophila melanogaster (Fruit fly) TR23400_c1_g1_i1 Q86XL3 ANKL2_HUMAN 2.00E-16 GO:0051301; GO:0030176; GO:0007067; GO:0007084; GO:0042326; GO:0035307; GO:0051721; GO:0008601 Q19848 cell division; integral to endoplasmic reticulum membrane; mitosis; mitotic nuclear envelope reassembly; negative regulation of phosphorylation; positive regulation of protein dephosphorylation; protein phosphatase 2A binding; protein phosphatase type 2A regulator activity IPR002110; IPR020683; IPR011015; IPR003887; IPR011320; Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) ANKLE2 KIAA0692 LEM4 Homo sapiens (Human) TR23403_c0_g1_i1 O77245 E75_METEN 1.00E-66 GO:0005634; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Nuclear hormone receptor E75 (Nuclear receptor subfamily 1 group D member 3) E75 NR1D3 Metapenaeus ensis (Greasyback shrimp) (Sand shrimp) TR23407_c0_g1_i1 Q9VUX2 MIB_DROME 1.00E-06 GO:0007219; GO:0045179; GO:0005829; GO:0006897; GO:0046331; GO:0045747; GO:0008104; GO:0007423; GO:0004842; GO:0008270 Notch signaling pathway; apical cortex; cytosol; endocytosis; lateral inhibition; positive regulation of Notch signaling pathway; protein localization; sensory organ development; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase mind-bomb (EC 6.3.2.-) (Mind bomb homolog) (D-mib) mib1 mind-bomb CG5841 Drosophila melanogaster (Fruit fly) TR23408_c0_g2_i1 Q9D5V2 KLH10_MOUSE 8.00E-96 GO:0000902; GO:0005737; GO:0009566; GO:0048873; GO:0048808; GO:0008584; GO:0016567; GO:0007286 cell morphogenesis; cytoplasm; fertilization; homeostasis of number of cells within a tissue; male genitalia morphogenesis; male gonad development; protein ubiquitination; spermatid development IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 10 Klhl10 Mus musculus (Mouse) TR23408_c0_g3_i1 Q6JEL2 KLH10_HUMAN 1.00E-31 GO:0000902; GO:0005737; GO:0009566; GO:0048873; GO:0048808; GO:0008584; GO:0016567; GO:0007286 cell morphogenesis; cytoplasm; fertilization; homeostasis of number of cells within a tissue; male genitalia morphogenesis; male gonad development; protein ubiquitination; spermatid development IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 10 KLHL10 Homo sapiens (Human) TR23415_c1_g1_i1 Q1H9T6 ZBT48_MOUSE 1.00E-15 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 48 (Krueppel-related zinc finger protein 3) (Protein HKR3) Zbtb48 Hkr3 Mus musculus (Mouse) TR23415_c1_g2_i1 Q642B9 ZNF18_RAT 4.00E-10 GO:0003677; GO:0046872; GO:0005634; GO:0000981 DNA binding; metal ion binding; nucleus; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR001909; IPR008916; IPR003309; IPR027764; IPR007087; IPR015880; IPR013087; Zinc finger protein 18 (Zinc finger protein 535) Znf18 Zfp18 Zfp535 Rattus norvegicus (Rat) TR23416_c2_g1_i1 B5EA63 MUTS_GEOBB 1.00E-19 GO:0005524; GO:0003684; GO:0006298; GO:0030983 ATP binding; damaged DNA binding; mismatch repair; mismatched DNA binding IPR005748; IPR007695; IPR000432; IPR007861; IPR007696; IPR016151; IPR007860; IPR027417; DNA mismatch repair protein MutS mutS Gbem_1753 Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622) TR23416_c2_g2_i1 P13705 MSH3_MOUSE 6.00E-72 GO:0005524; GO:0008094; GO:0032302; GO:0000403; GO:0019237; GO:0003684; GO:0000406; GO:0000404; GO:0043570; GO:0000710; GO:0000228; GO:0007131; GO:0016447 ATP binding; DNA-dependent ATPase activity; MutSbeta complex; Y-form DNA binding; centromeric DNA binding; damaged DNA binding; double-strand/single-strand DNA junction binding; loop DNA binding; maintenance of DNA repeat elements; meiotic mismatch repair; nuclear chromosome; reciprocal meiotic recombination; somatic recombination of immunoglobulin gene segments IPR007695; IPR000432; IPR007861; IPR007696; IPR016151; IPR007860; IPR027417; DNA mismatch repair protein Msh3 (Protein repair-1) (REP-1) (Protein repair-3) (REP-3) Msh3 Rep-3 Mus musculus (Mouse) TR23418_c1_g1_i1 Q9BYZ6 RHBT2_HUMAN 3.00E-06 GO:0005525; GO:0005829; GO:0005886; GO:0051056; GO:0007264 GTP binding; cytosol; plasma membrane; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR000210; IPR011333; IPR013069; IPR027417; IPR001806; IPR003578; Rho-related BTB domain-containing protein 2 (Deleted in breast cancer 2 gene protein) (p83) RHOBTB2 DBC2 KIAA0717 Homo sapiens (Human) TR23418_c3_g1_i1 O94844 RHBT1_HUMAN 1.00E-54 GO:0005525; GO:0005829; GO:0005886; GO:0051056; GO:0007264 GTP binding; cytosol; plasma membrane; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR000210; IPR011333; IPR013069; IPR027417; IPR001806; IPR003578; Rho-related BTB domain-containing protein 1 RHOBTB1 KIAA0740 Homo sapiens (Human) TR23418_c4_g1_i1 O94955 RHBT3_HUMAN 1.00E-11 GO:0005524; GO:0016887; GO:0005525; GO:0005794; GO:0042147; GO:0007264 P24408 "ATP binding; ATPase activity; GTP binding; Golgi apparatus; retrograde transport, endosome to Golgi; small GTPase mediated signal transduction" IPR000210; IPR011333; IPR013069; IPR027417; IPR001806; Rho-related BTB domain-containing protein 3 (EC 3.6.1.-) RHOBTB3 KIAA0878 Homo sapiens (Human) TR23425_c0_g1_i1 Q9JLB4 CUBN_MOUSE 7.00E-07 GO:0005794; GO:0016324; GO:0005903; GO:0005509; GO:0008203; GO:0005905; GO:0031419; GO:0030139; GO:0005783; GO:0005768; GO:0010008; GO:0042953; GO:0005765; GO:0004872; GO:0006898 Golgi apparatus; apical plasma membrane; brush border; calcium ion binding; cholesterol metabolic process; coated pit; cobalamin binding; endocytic vesicle; endoplasmic reticulum; endosome; endosome membrane; lipoprotein transport; lysosomal membrane; receptor activity; receptor-mediated endocytosis IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; Cubilin (Intrinsic factor-cobalamin receptor) Cubn Ifcr Mus musculus (Mouse) TR23426_c0_g1_i1 A3KPN8 TTC38_DANRE 5.00E-81 IPR011990; Tetratricopeptide repeat protein 38 (TPR repeat protein 38) ttc38 si:ch211-249g22.2 zgc:112407 Danio rerio (Zebrafish) (Brachydanio rerio) TR23428_c0_g1_i1 Q12830 BPTF_HUMAN 5.00E-65 GO:0016589; GO:0009952; GO:0007420; GO:0006338; GO:0005737; GO:0001892; GO:0007492; GO:0000122; GO:0045893; GO:0043565; GO:0008134; GO:0006351; GO:0008270 Q71DI3; P62805 "NURF complex; anterior/posterior pattern specification; brain development; chromatin remodeling; cytoplasm; embryonic placenta development; endoderm development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription factor binding; transcription, DNA-dependent; zinc ion binding" IPR001487; IPR018359; IPR004022; IPR018500; IPR018501; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) BPTF FAC1 FALZ Homo sapiens (Human) TR23433_c2_g1_i1 Q24306 IAP1_DROME 1.00E-27 GO:0019788; GO:0016055; GO:0048800; GO:0007298; GO:0008407; GO:0004869; GO:0005737; GO:0008354; GO:0097340; GO:1990001; GO:0043066; GO:0046673; GO:0005634; GO:0090263; GO:0031398; GO:0042787; GO:0045035; GO:0007289; GO:0004842; GO:0008270 P25843; Q86PE7; Q9XYF4; Q24475; Q24106 NEDD8 ligase activity; Wnt receptor signaling pathway; antennal morphogenesis; border follicle cell migration; chaeta morphogenesis; cysteine-type endopeptidase inhibitor activity; cytoplasm; germ cell migration; inhibition of cysteine-type endopeptidase activity; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of compound eye retinal cell programmed cell death; nucleus; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; sensory organ precursor cell division; spermatid nucleus differentiation; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; Apoptosis 1 inhibitor (EC 6.3.2.-) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (dIAP1) (Protein thread) th Iap1 CG12284 Drosophila melanogaster (Fruit fly) TR23433_c3_g1_i1 Q6R7I2 IAP1_OSHVF 1.00E-07 GO:0008270 zinc ion binding IPR001370; IPR001841; IPR013083; Putative apoptosis inhibitor ORF42 ORF42 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) TR23439_c0_g1_i1 Q9C0E4 GRIP2_HUMAN 2.00E-36 GO:0005829; GO:0005886; GO:0007268 cytosol; plasma membrane; synaptic transmission IPR001478; Glutamate receptor-interacting protein 2 (GRIP-2) GRIP2 KIAA1719 Homo sapiens (Human) TR23439_c3_g1_i1 P97879 GRIP1_RAT 2.00E-36 GO:0030054; GO:0005789; GO:0007399; GO:0043025; GO:0014069; GO:0045211; GO:0015031 Q8CGU4; P19491; P19492; P19493; Q9WTW1-3; P35400; Q13136; Q91Z79; Q91Z80; Q9WUL3 cell junction; endoplasmic reticulum membrane; nervous system development; neuronal cell body; postsynaptic density; postsynaptic membrane; protein transport IPR001478; Glutamate receptor-interacting protein 1 (GRIP-1) (AMPA receptor-interacting protein GRIP1) Grip1 Rattus norvegicus (Rat) TR23439_c4_g1_i1 P97879 GRIP1_RAT 7.00E-27 GO:0030054; GO:0005789; GO:0007399; GO:0043025; GO:0014069; GO:0045211; GO:0015031 Q8CGU4; P19491; P19492; P19493; Q9WTW1-3; P35400; Q13136; Q91Z79; Q91Z80; Q9WUL3 cell junction; endoplasmic reticulum membrane; nervous system development; neuronal cell body; postsynaptic density; postsynaptic membrane; protein transport IPR001478; Glutamate receptor-interacting protein 1 (GRIP-1) (AMPA receptor-interacting protein GRIP1) Grip1 Rattus norvegicus (Rat) TR23439_c5_g1_i1 Q9Z250 LIN7A_RAT 2.00E-09 GO:0016323; GO:0006887; GO:0043005; GO:0014069; GO:0045211; GO:0015031; GO:0045202; GO:0005923 basolateral plasma membrane; exocytosis; neuron projection; postsynaptic density; postsynaptic membrane; protein transport; synapse; tight junction IPR004172; IPR014775; IPR017365; IPR001478; Protein lin-7 homolog A (Lin-7A) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1) Lin7a Mals1 Veli1 Rattus norvegicus (Rat) TR23440_c0_g1_i1 Q7ZVP1 JADE3_DANRE 2.00E-16 GO:0008270 zinc ion binding IPR019542; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Protein Jade-3 (PHD finger protein 16) phf16 jade3 Danio rerio (Zebrafish) (Brachydanio rerio) TR23445_c1_g1_i1 A8XZB0 ATIF2_CAEBR 1.00E-10 GO:0004857; GO:0005739; GO:0043086; GO:0045980 enzyme inhibitor activity; mitochondrion; negative regulation of catalytic activity; negative regulation of nucleotide metabolic process IPR007648; "ATPase inhibitor mai-2, mitochondrial" mai-2 CBG21048 Caenorhabditis briggsae TR23447_c1_g1_i1 Q05DH4 F16A1_HUMAN 1.00E-36 IPR019384; Protein FAM160A1 FAM160A1 Homo sapiens (Human) TR23448_c3_g1_i1 Q502M6 ANR29_DANRE 4.00E-11 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) TR23449_c3_g2_i1 O74745 ANP1_SCHPO 4.00E-13 GO:0000138; GO:0000136; GO:0005783; GO:0005789; GO:0006487 "Golgi trans cisterna; alpha-1,6-mannosyltransferase complex; endoplasmic reticulum; endoplasmic reticulum membrane; protein N-linked glycosylation" IPR005109; Mannan polymerase II complex anp1 subunit (M-Pol II subunit anp1) anp1 SPBC1734.04 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR23451_c0_g1_i1 Q9DAK9 PHP14_MOUSE 5.00E-28 GO:0019855; GO:0005829; GO:2000984; GO:0050860; GO:0051350; GO:0035971; GO:0008969; GO:0004721; GO:2000147; GO:2000249 calcium channel inhibitor activity; cytosol; negative regulation of ATP citrate synthase activity; negative regulation of T cell receptor signaling pathway; negative regulation of lyase activity; peptidyl-histidine dephosphorylation; phosphohistidine phosphatase activity; phosphoprotein phosphatase activity; positive regulation of cell motility; regulation of actin cytoskeleton reorganization IPR007702; 14 kDa phosphohistidine phosphatase (EC 3.1.3.-) (Phosphohistidine phosphatase 1) Phpt1 Php14 Mus musculus (Mouse) TR23459_c0_g1_i1 O88572 LRP6_MOUSE 3.00E-08 GO:0044332; GO:0021874; GO:0090244; GO:0042813; GO:0090245; GO:0046849; GO:0060444; GO:0061310; GO:0061324; GO:0005901; GO:0042074; GO:0009986; GO:0071397; GO:0021587; GO:0021795; GO:0060026; GO:0015026; GO:0071936; GO:0031410; GO:0071542; GO:0005769; GO:0048596; GO:0042733; GO:0035115; GO:0035116; GO:0009880; GO:0060059; GO:0005783; GO:0035261; GO:0060325; GO:0021861; GO:0021943; GO:0001947; GO:0016021; GO:0019210; GO:0005041; GO:0060596; GO:0030901; GO:0030917; GO:0050680; GO:0045599; GO:2000151; GO:2000162; GO:2000168; GO:2000164; GO:2000166; GO:2000149; GO:0071901; GO:0034392; GO:0014029; GO:0001843; GO:0043025; GO:0042475; GO:0060021; GO:0003344; GO:2000055; GO:0043065; GO:0045780; GO:0090263; GO:0045787; GO:0002053; GO:0045778; GO:0051091; GO:0045944; GO:0036342; GO:0090009; GO:0043235; GO:0090118; GO:0060284; GO:0051593; GO:0048705; GO:0045202; GO:0007268; GO:0021794; GO:0019534; GO:0060535 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt receptor signaling pathway involved in forebrain neuroblast division; Wnt receptor signaling pathway involved in somitogenesis; Wnt-activated receptor activity; axis elongation involved in somitogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development; canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; caveola; cell migration involved in gastrulation; cell surface; cellular response to cholesterol; cerebellum morphogenesis; cerebral cortex cell migration; convergent extension; coreceptor activity; coreceptor activity involved in Wnt receptor signaling pathway; cytoplasmic vesicle; dopaminergic neuron differentiation; early endosome; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic pattern specification; embryonic retina morphogenesis in camera-type eye; endoplasmic reticulum; external genitalia morphogenesis; face morphogenesis; forebrain radial glial cell differentiation; formation of radial glial scaffolds; heart looping; integral to membrane; kinase inhibitor activity; low-density lipoprotein receptor activity; mammary placode formation; midbrain development; midbrain-hindbrain boundary development; negative regulation of epithelial cell proliferation; negative regulation of fat cell differentiation; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis; negative regulation of planar cell polarity pathway involved in neural tube closure; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest formation; neural tube closure; neuronal cell body; odontogenesis of dentin-containing tooth; palate development; pericardium morphogenesis; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell cycle; positive regulation of mesenchymal cell proliferation; positive regulation of ossification; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; post-anal tail morphogenesis; primitive streak formation; receptor complex; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport; regulation of cell development; response to folic acid; skeletal system morphogenesis; synapse; synaptic transmission; thalamus development; toxin transporter activity; trachea cartilage morphogenesis IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 6 (LRP-6) Lrp6 Mus musculus (Mouse) TR23459_c0_g2_i1 Q6V0K7 OIT3_RAT 2.00E-12 GO:0005635 nuclear envelope IPR000742; IPR001507; Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein) Oit3 Lzp Rattus norvegicus (Rat) TR23465_c0_g1_i1 Q9Y283 INVS_HUMAN 3.00E-18 GO:0016055; GO:0005929; GO:0005737; GO:0060971; GO:0001822; GO:0016020; GO:0005874; GO:0090090; GO:0005634; GO:0031016; GO:0009791; GO:0005819 Q9BPU9 Wnt receptor signaling pathway; cilium; cytoplasm; embryonic heart tube left/right pattern formation; kidney development; membrane; microtubule; negative regulation of canonical Wnt receptor signaling pathway; nucleus; pancreas development; post-embryonic development; spindle IPR002110; IPR020683; IPR000048; Inversin (Inversion of embryo turning homolog) (Nephrocystin-2) INVS INV NPHP2 Homo sapiens (Human) TR23465_c0_g1_i2 Q12955 ANK3_HUMAN 1.00E-25 GO:0043001; GO:0030315; GO:0007411; GO:0043194; GO:0007409; GO:0016323; GO:0045296; GO:0009986; GO:0043034; GO:0014704; GO:0044325; GO:0016328; GO:0005764; GO:0072660; GO:0071709; GO:0000281; GO:0033268; GO:0033270; GO:0010628; GO:1900827; GO:0045838; GO:2000651; GO:0010765; GO:0045211; GO:0030674; GO:0072661; GO:0019228; GO:0043266; GO:0007165; GO:0030507; GO:0014731; GO:0005200; GO:0050808 "Golgi to plasma membrane protein transport; T-tubule; axon guidance; axon initial segment; axonogenesis; basolateral plasma membrane; cadherin binding; cell surface; costamere; intercalated disc; ion channel binding; lateral plasma membrane; lysosome; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; node of Ranvier; paranode region of axon; positive regulation of gene expression; positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; postsynaptic membrane; protein binding, bridging; protein targeting to plasma membrane; regulation of action potential in neuron; regulation of potassium ion transport; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton; synapse organization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) TR23465_c1_g1_i1 Q9J4Z5 V245_FOWPN 1.00E-14 IPR002110; IPR020683; Putative ankyrin repeat protein FPV245 FPV245 Fowlpox virus (strain NVSL) (FPV) TR23468_c0_g4_i1 Q24432 OMB_DROME 3.00E-41 GO:0003677; GO:0001745; GO:0048066; GO:0007476; GO:0000122; GO:0005634; GO:0035265; GO:0003700; GO:0006351; GO:0048100 "DNA binding; compound eye morphogenesis; developmental pigmentation; imaginal disc-derived wing morphogenesis; negative regulation of transcription from RNA polymerase II promoter; nucleus; organ growth; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; wing disc anterior/posterior pattern formation" IPR021101; IPR008967; IPR001699; IPR018186; Optomotor-blind protein (Lethal(1)optomotor-blind) (L(1)omb) (Protein bifid) bi OMB CG3578 Drosophila melanogaster (Fruit fly) TR23468_c0_g4_i2 Q24432 OMB_DROME 6.00E-47 GO:0003677; GO:0001745; GO:0048066; GO:0007476; GO:0000122; GO:0005634; GO:0035265; GO:0003700; GO:0006351; GO:0048100 "DNA binding; compound eye morphogenesis; developmental pigmentation; imaginal disc-derived wing morphogenesis; negative regulation of transcription from RNA polymerase II promoter; nucleus; organ growth; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; wing disc anterior/posterior pattern formation" IPR021101; IPR008967; IPR001699; IPR018186; Optomotor-blind protein (Lethal(1)optomotor-blind) (L(1)omb) (Protein bifid) bi OMB CG3578 Drosophila melanogaster (Fruit fly) TR23468_c3_g1_i1 P70324 TBX3_MOUSE 2.00E-45 GO:0008595; GO:0003167; GO:0001568; GO:0060444; GO:0060923; GO:0090398; GO:0042733; GO:0035115; GO:0030540; GO:0046884; GO:0001947; GO:0001701; GO:0021761; GO:0032275; GO:0030539; GO:0060596; GO:0048332; GO:0043066; GO:0030857; GO:0045662; GO:0000122; GO:0045892; GO:0005634; GO:0003151; GO:0060021; GO:0045787; GO:2000648; GO:0045893; GO:0043565; GO:0003700; GO:0060931; GO:0001501; GO:0010159; GO:0019827; GO:0006351; GO:0060412 "anterior/posterior axis specification, embryo; atrioventricular bundle cell differentiation; blood vessel development; branching involved in mammary gland duct morphogenesis; cardiac muscle cell fate commitment; cellular senescence; embryonic digit morphogenesis; embryonic forelimb morphogenesis; female genitalia development; follicle-stimulating hormone secretion; heart looping; in utero embryonic development; limbic system development; luteinizing hormone secretion; male genitalia development; mammary placode formation; mesoderm morphogenesis; negative regulation of apoptotic process; negative regulation of epithelial cell differentiation; negative regulation of myoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; outflow tract morphogenesis; palate development; positive regulation of cell cycle; positive regulation of stem cell proliferation; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sinoatrial node cell development; skeletal system development; specification of organ position; stem cell maintenance; transcription, DNA-dependent; ventricular septum morphogenesis" IPR008967; IPR022582; IPR001699; IPR018186; T-box transcription factor TBX3 (T-box protein 3) Tbx3 Mus musculus (Mouse) TR23470_c1_g2_i1 Q10983 FUT2_RABIT 3.00E-06 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Secretor blood group alpha-2-fucosyltransferase)" FUT2 RFT-II SEC1 Oryctolagus cuniculus (Rabbit) TR23471_c0_g1_i1 A0M8R6 CAV1_PAPAN 9.00E-23 GO:0000139; GO:0031295; GO:0005901; GO:0005768 Golgi membrane; T cell costimulation; caveola; endosome IPR001612; IPR015504; IPR018361; Caveolin-1 CAV1 Papio anubis (Olive baboon) TR23472_c1_g2_i1 A8WGS4 TLCD2_DANRE 7.00E-19 GO:0016021 integral to membrane IPR006634; TLC domain-containing protein 2 tlcd2 zgc:175098 Danio rerio (Zebrafish) (Brachydanio rerio) TR23473_c0_g1_i1 Q921V7 CTL3_MOUSE 2.00E-07 GO:0016021 integral to membrane IPR007603; Choline transporter-like protein 3 (Solute carrier family 44 member 3) Slc44a3 Ctl3 Mus musculus (Mouse) TR23473_c2_g1_i1 Q8VII6 CTL1_RAT 6.00E-18 GO:0016021; GO:0006810 integral to membrane; transport IPR007603; Choline transporter-like protein 1 (Solute carrier family 44 member 1) (CD antigen CD92) Slc44a1 Cd92 Cdw92 Ctl1 Rattus norvegicus (Rat) TR23475_c1_g1_i1 Q03412 UNC7_CAEEL 9.00E-46 GO:0005921; GO:0016264; GO:0055077; GO:0016021; GO:0034220; GO:0040011; GO:0032589; GO:0018991; GO:0043051; GO:0042221 gap junction; gap junction assembly; gap junction hemi-channel activity; integral to membrane; ion transmembrane transport; locomotion; neuron projection membrane; oviposition; regulation of pharyngeal pumping; response to chemical stimulus IPR000990; Innexin unc-7 (Uncoordinated protein 7) unc-7 unc-12 unc-124 R07D5.1 Caenorhabditis elegans TR23475_c2_g1_i1 O01393 UNC9_CAEEL 2.00E-41 GO:0005921; GO:0055077; GO:0016021; GO:0034220; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transmembrane transport; plasma membrane IPR000990; Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans TR23481_c0_g2_i1 O92815 POL_WDSV 1.00E-08 GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0020002; GO:0016020; GO:0090305; GO:0006508; GO:0004523; GO:0039660; GO:0019013; GO:0008270 DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; host cell plasma membrane; membrane; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; structural constituent of virion; viral nucleocapsid; zinc ion binding IPR001584; IPR018061; IPR021109; IPR012337; IPR002156; IPR000477; IPR001878; Gag-Pol polyprotein [Cleaved into: Matrix protein p10 (MA); p20; Capsid protein p25 (CA); Nucleocapsid protein p14 (NC-pol); Protease p15 (PR) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H p90 (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase p46 (IN)] gag-pol Walleye dermal sarcoma virus (WDSV) TR23481_c1_g1_i1 P10401 POLY_DROME 3.00E-19 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0090305 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon gypsy [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR23481_c2_g1_i1 O93209 POL_FFV 2.00E-08 GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0075713; GO:0030430; GO:0042025; GO:0046872; GO:0090305; GO:0006508; GO:0004523; GO:0046718; GO:0075732; GO:0019012 DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; establishment of integrated proviral latency; host cell cytoplasm; host cell nucleus; metal ion binding; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; viral entry into host cell; viral penetration into host nucleus; virion IPR001584; IPR012337; IPR002156; IPR000477; IPR001641; Pro-Pol polyprotein (Pr125Pol) [Cleaved into: Protease/Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (EC 3.4.23.-) (p87Pro-RT-RNaseH); Protease/Reverse transcriptase (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.4.23.-) (p65Pro-RT); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN) (p42In)] pol Feline foamy virus (FFV) (Feline syncytial virus) TR23481_c2_g2_i1 Q7M732 RTL1_MOUSE 1.00E-05 GO:0016021; GO:0007275 integral to membrane; multicellular organismal development IPR021109; IPR005162; Retrotransposon-like protein 1 (Mammalian retrotransposon derived protein 1) (Paternally expressed gene 11 protein) (Retrotransposon-derived protein PEG11) Rtl1 Mar1 Mart1 Peg11 Mus musculus (Mouse) TR23481_c3_g1_i1 P92523 M860_ARATH 6.00E-17 GO:0005739 mitochondrion Uncharacterized mitochondrial protein AtMg00860 (ORF158) AtMg00860 Arabidopsis thaliana (Mouse-ear cress) TR23488_c0_g1_i1 Q99LZ3 SLD5_MOUSE 2.00E-81 GO:0006260; GO:0005737; GO:0005634 DNA replication; cytoplasm; nucleus IPR021151; IPR008591; "DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed]" Gins4 Sld5 Mus musculus (Mouse) TR23498_c0_g2_i1 P30904 MIF_RAT 2.00E-29 GO:0007568; GO:0007420; GO:0002035; GO:0070301; GO:0071456; GO:0005737; GO:0004167; GO:0042756; GO:0005615; GO:0001942; GO:0006954; GO:0045087; GO:0005634; GO:0050178; GO:0002675; GO:0048680; GO:0046326; GO:0045821; GO:0050778; GO:0043268; GO:0014911; GO:0032403; GO:0042493; GO:0032355; GO:0051384; GO:0009408; GO:0032868; GO:0032496; GO:0009612; GO:0032572; GO:0032570; GO:0033197; GO:0007283; GO:0042060 aging; brain development; brain renin-angiotensin system; cellular response to hydrogen peroxide; cellular response to hypoxia; cytoplasm; dopachrome isomerase activity; drinking behavior; extracellular space; hair follicle development; inflammatory response; innate immune response; nucleus; phenylpyruvate tautomerase activity; positive regulation of acute inflammatory response; positive regulation of axon regeneration; positive regulation of glucose import; positive regulation of glycolysis; positive regulation of immune response; positive regulation of potassium ion transport; positive regulation of smooth muscle cell migration; protein complex binding; response to drug; response to estradiol stimulus; response to glucocorticoid stimulus; response to heat; response to insulin stimulus; response to lipopolysaccharide; response to mechanical stimulus; response to menaquinone; response to progesterone stimulus; response to vitamin E; spermatogenesis; wound healing IPR001398; IPR019829; IPR014347; Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glutathione-binding 13 kDa protein) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) Mif Rattus norvegicus (Rat) TR23499_c3_g1_i3 Q5ZK63 TCP4_CHICK 3.00E-06 GO:0003677; GO:0005634; GO:0006355; GO:0003713; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent" IPR003173; IPR009044; Activated RNA polymerase II transcriptional coactivator p15 (SUB1 homolog) SUB1 RPO2TC1 RCJMB04_12p22 Gallus gallus (Chicken) TR23500_c0_g2_i1 Q5STE3 FSTL4_MOUSE 7.00E-13 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR011992; IPR018247; IPR002048; IPR007110; IPR013783; IPR013098; IPR003598; IPR002350; IPR015943; Follistatin-related protein 4 (Follistatin-like protein 4) (m-D/Bsp120I 1-1) Fstl4 Kiaa1061 Mus musculus (Mouse) TR23500_c0_g3_i1 Q6MZW2 FSTL4_HUMAN 2.00E-11 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR011992; IPR018247; IPR002048; IPR007110; IPR013783; IPR013098; IPR003598; IPR002350; IPR015943; Follistatin-related protein 4 (Follistatin-like protein 4) FSTL4 KIAA1061 Homo sapiens (Human) TR23500_c1_g1_i1 Q8N475 FSTL5_HUMAN 9.00E-16 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR011992; IPR018247; IPR002048; IPR007110; IPR013783; IPR013098; IPR003598; IPR002350; IPR015943; Follistatin-related protein 5 (Follistatin-like protein 5) FSTL5 KIAA1263 Homo sapiens (Human) TR23502_c0_g2_i1 P58283 RN216_MOUSE 3.00E-84 GO:0006915; GO:0005737; GO:0016874; GO:0043161; GO:0070936; GO:0050691; GO:0032648; GO:0008270 apoptotic process; cytoplasm; ligase activity; proteasomal ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; regulation of defense response to virus by host; regulation of interferon-beta production; zinc ion binding IPR002867; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF216 (EC 6.3.2.-) (RING finger protein 216) (Triad domain-containing protein 3) (UbcM4-interacting protein 83) (Ubiquitin-conjugating enzyme 7-interacting protein 1) Rnf216 Triad3 Ubce7ip1 Uip83 Zin Mus musculus (Mouse) TR23506_c0_g1_i1 Q924X6 LRP8_MOUSE 4.00E-20 GO:0021541; GO:0034185; GO:0005509; GO:0005615; GO:0016021; GO:0021819; GO:0005041; GO:0000122; GO:0005886; GO:0032793; GO:1900006; GO:0061003; GO:0061098; GO:0038025; GO:0050804; GO:0021517 Q62108; P35438 ammon gyrus development; apolipoprotein binding; calcium ion binding; extracellular space; integral to membrane; layer formation in cerebral cortex; low-density lipoprotein receptor activity; negative regulation of transcription from RNA polymerase II promoter; plasma membrane; positive regulation of CREB transcription factor activity; positive regulation of dendrite development; positive regulation of dendritic spine morphogenesis; positive regulation of protein tyrosine kinase activity; reelin receptor activity; regulation of synaptic transmission; ventral spinal cord development IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2) Lrp8 Apoer2 Mus musculus (Mouse) TR23506_c2_g1_i1 P98158 LRP2_RAT 3.00E-24 GO:0007568; GO:0016324; GO:0031526; GO:0005509; GO:0005905; GO:0016197; GO:0005768; GO:0005615; GO:0030492; GO:0020028; GO:0046879; GO:0016021; GO:0042953; GO:0045121; GO:0010951; GO:0031100; GO:0043234; GO:0004872; GO:0006898; GO:0010165; GO:0042493; GO:0032526; GO:0033280; GO:0045056; GO:0006766 O88797 aging; apical plasma membrane; brush border membrane; calcium ion binding; coated pit; endosomal transport; endosome; extracellular space; hemoglobin binding; hemoglobin import; hormone secretion; integral to membrane; lipoprotein transport; membrane raft; negative regulation of endopeptidase activity; organ regeneration; protein complex; receptor activity; receptor-mediated endocytosis; response to X-ray; response to drug; response to retinoic acid; response to vitamin D; transcytosis; vitamin metabolic process IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) Lrp2 Rattus norvegicus (Rat) TR23508_c0_g1_i1 P28824 NRP1_XENLA 2.00E-10 GO:0001525; GO:0007411; GO:0007155; GO:0035767; GO:0008201; GO:0016021; GO:0046872; GO:0009887; GO:0017154; GO:0048010; GO:0005021 angiogenesis; axon guidance; cell adhesion; endothelial cell chemotaxis; heparin binding; integral to membrane; metal ion binding; organ morphogenesis; semaphorin receptor activity; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor-activated receptor activity IPR000421; IPR008985; IPR000859; IPR008979; IPR000998; IPR014648; IPR022579; IPR027146; Neuropilin-1 (A5 antigen) (A5 protein) nrp1 Xenopus laevis (African clawed frog) TR23508_c0_g2_i1 Q6UXC1 AEGP_HUMAN 3.00E-14 GO:0016021; GO:0015031 integral to membrane; protein transport IPR008985; IPR023415; IPR002172; IPR000998; Apical endosomal glycoprotein (MAM domain-containing protein 4) MAMDC4 AEGP UNQ3001/PRO9742 Homo sapiens (Human) TR23511_c1_g1_i1 Q9BZF1 OSBL8_HUMAN 7.00E-19 GO:0015485; GO:0045444; GO:0006869; GO:0010891; GO:0005543 cholesterol binding; fat cell differentiation; lipid transport; negative regulation of sequestering of triglyceride; phospholipid binding IPR000648; IPR018494; IPR011993; IPR001849; Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) OSBPL8 KIAA1451 ORP8 OSBP10 Homo sapiens (Human) TR23511_c7_g1_i1 Q9H0X9 OSBL5_HUMAN 2.00E-24 GO:0006893; GO:0015485; GO:0008203; GO:0030301; GO:0005829; GO:0005789; GO:0016021; GO:0008142; GO:0005543 Golgi to plasma membrane transport; cholesterol binding; cholesterol metabolic process; cholesterol transport; cytosol; endoplasmic reticulum membrane; integral to membrane; oxysterol binding; phospholipid binding IPR000648; IPR018494; IPR011993; IPR001849; Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1) OSBPL5 KIAA1534 OBPH1 ORP5 Homo sapiens (Human) TR23513_c0_g2_i3 P42519 STAR_DROME 6.00E-07 GO:0005794; GO:0000139; GO:0048149; GO:0046845; GO:0046667; GO:0035225; GO:0005789; GO:0038004; GO:0007173; GO:0061331; GO:0007476; GO:0016021; GO:0007498; GO:0016318; GO:0048477; GO:0097038; GO:0007422; GO:0042461; GO:0005886; GO:0000042; GO:0048865; GO:0007421; GO:0007601 "Golgi apparatus; Golgi membrane; behavioral response to ethanol; branched duct epithelial cell fate determination, open tracheal system; compound eye retinal cell programmed cell death; determination of genital disc primordium; endoplasmic reticulum membrane; epidermal growth factor receptor ligand maturation; epidermal growth factor receptor signaling pathway; epithelial cell proliferation involved in Malpighian tubule morphogenesis; imaginal disc-derived wing morphogenesis; integral to membrane; mesoderm development; ommatidial rotation; oogenesis; perinuclear endoplasmic reticulum; peripheral nervous system development; photoreceptor cell development; plasma membrane; protein targeting to Golgi; stem cell fate commitment; stomatogastric nervous system development; visual perception" IPR006342; Protein Star S CG4385 Drosophila melanogaster (Fruit fly) TR23522_c1_g1_i1 Q8BIR2 ASTE1_MOUSE 4.00E-08 IPR026832; Protein asteroid homolog 1 Aste1 Mus musculus (Mouse) TR23524_c0_g2_i1 P46782 RS5_HUMAN 2.00E-129 GO:0006614; GO:0022627; GO:0003729; GO:0000184; GO:0006450; GO:0003735; GO:0006414; GO:0006413; GO:0006415; GO:0019083 "SRP-dependent cotranslational protein targeting to membrane; cytosolic small ribosomal subunit; mRNA binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; regulation of translational fidelity; structural constituent of ribosome; translational elongation; translational initiation; translational termination; viral transcription" IPR000235; IPR005716; IPR020606; IPR023798; "40S ribosomal protein S5 [Cleaved into: 40S ribosomal protein S5, N-terminally processed]" RPS5 Homo sapiens (Human) TR23536_c0_g1_i2 P49707 CCNE1_CHICK 1.00E-57 GO:0007049; GO:0051301; GO:0005634; GO:0000079 cell cycle; cell division; nucleus; regulation of cyclin-dependent protein serine/threonine kinase activity IPR013763; IPR014400; IPR004367; IPR006671; G1/S-specific cyclin-E1 CCNE1 CCNE Gallus gallus (Chicken) TR23536_c1_g1_i1 P39949 CCNE1_RAT 6.00E-50 GO:0001547; GO:0007049; GO:0051301; GO:0031670; GO:0005813; GO:0005737; GO:0001889; GO:0005634; GO:0031100; GO:0045597; GO:0000079; GO:0051412; GO:0034097; GO:0042493; GO:0032355; GO:0045471; GO:0051597; GO:0032570; GO:0014074; GO:0033197 antral ovarian follicle growth; cell cycle; cell division; cellular response to nutrient; centrosome; cytoplasm; liver development; nucleus; organ regeneration; positive regulation of cell differentiation; regulation of cyclin-dependent protein serine/threonine kinase activity; response to corticosterone stimulus; response to cytokine stimulus; response to drug; response to estradiol stimulus; response to ethanol; response to methylmercury; response to progesterone stimulus; response to purine-containing compound; response to vitamin E IPR013763; IPR014400; IPR004367; IPR006671; G1/S-specific cyclin-E1 Ccne1 Ccne Rattus norvegicus (Rat) TR23540_c2_g1_i1 Q70J99 UN13D_HUMAN 2.00E-06 GO:0051607; GO:0070382; GO:0002467; GO:0002432; GO:0005770; GO:0005764; GO:0016020; GO:0043320; GO:0006909; GO:0045921; GO:0055037; GO:0043304 defense response to virus; exocytic vesicle; germinal center formation; granuloma formation; late endosome; lysosome; membrane; natural killer cell degranulation; phagocytosis; positive regulation of exocytosis; recycling endosome; regulation of mast cell degranulation IPR000008; IPR014770; IPR014772; IPR019558; Protein unc-13 homolog D (Munc13-4) UNC13D Homo sapiens (Human) TR23542_c2_g1_i3 Q9UMZ2 SYNRG_HUMAN 2.00E-24 GO:0030121; GO:0005509; GO:0006897; GO:0006886 AP-1 adaptor complex; calcium ion binding; endocytosis; intracellular protein transport IPR011992; IPR000261; Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) SYNRG AP1GBP1 SYNG Homo sapiens (Human) TR23542_c3_g1_i1 Q9UMZ2 SYNRG_HUMAN 2.00E-36 GO:0030121; GO:0005509; GO:0006897; GO:0006886 AP-1 adaptor complex; calcium ion binding; endocytosis; intracellular protein transport IPR011992; IPR000261; Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) SYNRG AP1GBP1 SYNG Homo sapiens (Human) TR23543_c0_g1_i1 Q66J54 S226A_XENLA 3.00E-27 GO:0016021; GO:0015075; GO:0005886 integral to membrane; ion transmembrane transporter activity; plasma membrane IPR020846; IPR016196; IPR004749; IPR005828; IPR005829; Solute carrier family 22 member 6-A (Organic cation transporter 1-A) (Renal organic anion transporter 1-A) (ROAT1-A) slc22a6-a oat1-a Xenopus laevis (African clawed frog) TR23543_c0_g2_i2 Q6NUB3 S22AF_XENLA 4.00E-33 GO:0016021; GO:0006811; GO:0022857 integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Solute carrier family 22 member 15 slc22a15 Xenopus laevis (African clawed frog) TR23547_c4_g1_i1 Q22706 EXOC2_CAEEL 4.00E-08 GO:0006887; GO:0015031 exocytosis; protein transport IPR013783; IPR014756; IPR002909; Exocyst complex component 2 (Exocyst complex component Sec5) sec-5 T23G7.4 Caenorhabditis elegans TR23548_c2_g1_i1 Q9NUV9 GIMA4_HUMAN 5.00E-39 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR23554_c3_g2_i1 Q9P2E3 ZNFX1_HUMAN 8.00E-29 GO:0046872 metal ion binding IPR016024; IPR027417; NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) TR23554_c3_g2_i2 Q54I89 RENT1_DICDI 7.00E-13 GO:0005524; GO:0004004; GO:0003677; GO:0005737; GO:0000184; GO:0003676; GO:0008270 "ATP binding; ATP-dependent RNA helicase activity; DNA binding; cytoplasm; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleic acid binding; zinc ion binding" IPR027417; IPR018999; Regulator of nonsense transcripts 1 (EC 3.6.4.-) (Up-frameshift suppressor 1 homolog) upf1 DDB_G0288923 Dictyostelium discoideum (Slime mold) TR23555_c5_g1_i1 Q08E40 S39AC_BOVIN 2.00E-47 GO:0016021; GO:0046873; GO:0006829 integral to membrane; metal ion transmembrane transporter activity; zinc ion transport IPR003689; Zinc transporter ZIP12 (Solute carrier family 39 member 12) (Zrt- and Irt-like protein 12) (ZIP-12) SLC39A12 ZIP12 Bos taurus (Bovine) TR23558_c0_g1_i1 Q90ZZ5 NANO1_XENBO 1.00E-17 GO:0003723; GO:0007281; GO:0008354; GO:0060293; GO:0048471; GO:0030371; GO:0008270 RNA binding; germ cell development; germ cell migration; germ plasm; perinuclear region of cytoplasm; translation repressor activity; zinc ion binding IPR008705; IPR024161; Nanos homolog 1 (Xcat-2 protein) nanos1 xcat-2 Xenopus borealis (Kenyan clawed frog) TR23560_c3_g1_i1 O59933 MSMO_CANAL 1.00E-14 GO:0000254; GO:0000248; GO:0035690; GO:0005783; GO:0005789; GO:0006696; GO:0006633; GO:0036180; GO:0016021; GO:0005506; GO:0009405; GO:0005886 C-4 methylsterol oxidase activity; C-5 sterol desaturase activity; cellular response to drug; endoplasmic reticulum; endoplasmic reticulum membrane; ergosterol biosynthetic process; fatty acid biosynthetic process; filamentous growth of a population of unicellular organisms in response to biotic stimulus; integral to membrane; iron ion binding; pathogenesis; plasma membrane IPR006694; Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 3/6. Methylsterol monooxygenase (EC 1.14.13.72) (C-4 methylsterol oxidase) ERG25 CaO19.11216 CaO19.3732 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) TR23560_c3_g1_i2 Q96IV6 CE004_HUMAN 8.00E-42 GO:0006633; GO:0016021; GO:0005506; GO:0016491 fatty acid biosynthetic process; integral to membrane; iron ion binding; oxidoreductase activity IPR006694; Fatty acid hydroxylase domain-containing protein 2 FAXDC2 C5orf4 Homo sapiens (Human) TR23564_c2_g2_i1 Q6ZNF0 PAPL_HUMAN 1.00E-58 GO:0003993; GO:0005576; GO:0046872 acid phosphatase activity; extracellular region; metal ion binding IPR004843; IPR008963; IPR015914; IPR025733; Iron/zinc purple acid phosphatase-like protein (EC 3.1.3.2) PAPL Homo sapiens (Human) TR23566_c1_g1_i1 Q9HBF4 ZFYV1_HUMAN 7.00E-119 GO:0005545; GO:0005795; GO:0005783; GO:0010923; GO:0048471; GO:0005547; GO:0043325; GO:0008270 P62136 "1-phosphatidylinositol binding; Golgi stack; endoplasmic reticulum; negative regulation of phosphatase activity; perinuclear region of cytoplasm; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; zinc ion binding" IPR027417; IPR000306; IPR017455; IPR011011; IPR013083; Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (SR3) (Tandem FYVE fingers-1) ZFYVE1 DFCP1 KIAA1589 TAFF1 ZNFN2A1 PP10436 Homo sapiens (Human) TR23566_c1_g1_i2 Q6ZV73 FGD6_HUMAN 3.00E-09 GO:0005794; GO:0005089; GO:0030036; GO:0005856; GO:0046847; GO:0005085; GO:0030027; GO:0046872; GO:0005543; GO:0043088; GO:0008360; GO:0001726; GO:0031267 Golgi apparatus; Rho guanyl-nucleotide exchange factor activity; actin cytoskeleton organization; cytoskeleton; filopodium assembly; guanyl-nucleotide exchange factor activity; lamellipodium; metal ion binding; phospholipid binding; regulation of Cdc42 GTPase activity; regulation of cell shape; ruffle; small GTPase binding IPR000219; IPR011993; IPR001849; IPR000306; IPR017455; IPR013083; "FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24)" FGD6 KIAA1362 ZFYVE24 Homo sapiens (Human) TR23567_c5_g1_i1 Q6ZQY2 YV012_HUMAN 3.00E-20 Leucine-rich repeat-containing protein LOC400891 Homo sapiens (Human) TR2357_c0_g1_i1 Q96MM6 HS12B_HUMAN 1.00E-11 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR23581_c1_g1_i1 Q1JPJ9 FA86A_BOVIN 2.00E-19 GO:0005737 cytoplasm IPR019410; Protein FAM86A FAM86A Bos taurus (Bovine) TR23581_c2_g1_i1 Q96G04 FA86A_HUMAN 1.00E-20 GO:0005737 cytoplasm IPR019410; Protein FAM86A FAM86A SB153 Homo sapiens (Human) TR23583_c1_g1_i1 Q80WQ4 K1456_MOUSE 2.00E-22 GO:0008168 methyltransferase activity IPR013216; Putative methyltransferase KIAA1456 (EC 2.1.1.-) Kiaa1456 Mus musculus (Mouse) TR23586_c0_g1_i1 Q5EA95 IFT57_BOVIN 2.00E-167 GO:0003677; GO:0005794; GO:0006919; GO:0044292; GO:0005932; GO:0032391; GO:0006355; GO:0006351 "DNA binding; Golgi apparatus; activation of cysteine-type endopeptidase activity involved in apoptotic process; dendrite terminus; microtubule basal body; photoreceptor connecting cilium; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019530; Intraflagellar transport protein 57 homolog IFT57 Bos taurus (Bovine) TR23586_c0_g1_i6 Q5EA95 IFT57_BOVIN 3.00E-168 GO:0003677; GO:0005794; GO:0006919; GO:0044292; GO:0005932; GO:0032391; GO:0006355; GO:0006351 "DNA binding; Golgi apparatus; activation of cysteine-type endopeptidase activity involved in apoptotic process; dendrite terminus; microtubule basal body; photoreceptor connecting cilium; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019530; Intraflagellar transport protein 57 homolog IFT57 Bos taurus (Bovine) TR23588_c2_g1_i1 Q9BWF2 TRAIP_HUMAN 2.00E-11 GO:0006915; GO:0008283; GO:0005737; GO:0048471; GO:0005886; GO:0005057; GO:0007165; GO:0008270 P16333 apoptotic process; cell proliferation; cytoplasm; perinuclear region of cytoplasm; plasma membrane; receptor signaling protein activity; signal transduction; zinc ion binding IPR009053; IPR001841; IPR013083; TRAF-interacting protein (RING finger protein 206) TRAIP RNF206 TRIP Homo sapiens (Human) TR23591_c0_g1_i3 Q9JLJ0 LITAF_MOUSE 2.00E-17 GO:0005794; GO:0050699; GO:0006915; GO:0071222; GO:0005765; GO:0042347; GO:0005886; GO:0043123; GO:0001817; GO:0006355; GO:0004871; GO:0006351 P46935 "Golgi apparatus; WW domain binding; apoptotic process; cellular response to lipopolysaccharide; lysosomal membrane; negative regulation of NF-kappaB import into nucleus; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of cytokine production; regulation of transcription, DNA-dependent; signal transducer activity; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Estrogen-enhanced transcript protein) (mEET) (LITAF-like protein) (NEDD4 WW domain-binding protein 3) Litaf N4wbp3 Tbx1 Mus musculus (Mouse) TR23592_c0_g1_i2 Q1MX18 INSC_HUMAN 9.00E-09 GO:0045177; GO:0005737; GO:0000132; GO:0060487; GO:0007399 apical part of cell; cytoplasm; establishment of mitotic spindle orientation; lung epithelial cell differentiation; nervous system development IPR011989; IPR016024; Protein inscuteable homolog INSC Homo sapiens (Human) TR23595_c2_g1_i1 Q14CH1 MOCOS_MOUSE 0 GO:0006777; GO:0008265; GO:0030151; GO:0043545; GO:0030170; GO:0016740 Mo-molybdopterin cofactor biosynthetic process; Mo-molybdopterin cofactor sulfurase activity; molybdenum ion binding; molybdopterin cofactor metabolic process; pyridoxal phosphate binding; transferase activity IPR000192; IPR005302; IPR005303; IPR015424; IPR015421; IPR015422; IPR011037; Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (EC 2.8.1.9) (Molybdenum cofactor sulfurtransferase) Mocos Mus musculus (Mouse) TR23595_c2_g1_i2 Q14CH1 MOCOS_MOUSE 6.00E-129 GO:0006777; GO:0008265; GO:0030151; GO:0043545; GO:0030170; GO:0016740 Mo-molybdopterin cofactor biosynthetic process; Mo-molybdopterin cofactor sulfurase activity; molybdenum ion binding; molybdopterin cofactor metabolic process; pyridoxal phosphate binding; transferase activity IPR000192; IPR005302; IPR005303; IPR015424; IPR015421; IPR015422; IPR011037; Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (EC 2.8.1.9) (Molybdenum cofactor sulfurtransferase) Mocos Mus musculus (Mouse) TR23600_c0_g1_i1 Q9VKU7 GCP4_DROME 3.00E-58 GO:0045450; GO:0051298; GO:0008274; GO:0007112; GO:0005874; GO:0007020; GO:0007067; GO:0007052; GO:0007058; GO:0000922; GO:0005200 bicoid mRNA localization; centrosome duplication; gamma-tubulin ring complex; male meiosis cytokinesis; microtubule; microtubule nucleation; mitosis; mitotic spindle organization; spindle assembly involved in female meiosis II; spindle pole; structural constituent of cytoskeleton IPR007259; Gamma-tubulin complex component 4 homolog (Gamma-ring complex protein 75 kDa) (d75p) (dGrip75) Grip75 75p CG6176 Drosophila melanogaster (Fruit fly) TR23600_c0_g1_i2 Q9UGJ1 GCP4_HUMAN 0 GO:0000086; GO:0005813; GO:0005829; GO:0008274; GO:0005874; GO:0007020; GO:0006461; GO:0000922; GO:0005200 G2/M transition of mitotic cell cycle; centrosome; cytosol; gamma-tubulin ring complex; microtubule; microtubule nucleation; protein complex assembly; spindle pole; structural constituent of cytoskeleton IPR007259; Gamma-tubulin complex component 4 (GCP-4) (hGCP4) (Gamma-ring complex protein 76 kDa) (h76p) (hGrip76) TUBGCP4 76P GCP4 Homo sapiens (Human) TR23602_c0_g2_i1 Q9C1M7 DYHC_ASHGO 3.00E-13 GO:0005524; GO:0006200; GO:0016887; GO:0005737; GO:0030286; GO:0000741; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cytoplasm; dynein complex; karyogamy; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain, cytoplasmic (Dynein heavy chain, cytosolic) (DYHC)" DYN1 DHC1 ACR258W Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR23602_c2_g1_i1 Q0VDD8 DYH14_HUMAN 7.00E-38 GO:0005524; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR026983; IPR024743; IPR024317; IPR004273; IPR027417; "Dynein heavy chain 14, axonemal (Axonemal beta dynein heavy chain 14) (Ciliary dynein heavy chain 14)" DNAH14 C1orf67 Homo sapiens (Human) TR23602_c2_g1_i2 Q3V0Q1 DYH12_MOUSE 0 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018; GO:0016567 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement; protein ubiquitination IPR003593; IPR011704; IPR026983; IPR024317; IPR004273; IPR013602; IPR027417; Protein modification; protein ubiquitination. "Dynein heavy chain 12, axonemal (Axonemal beta dynein heavy chain 12) (Axonemal dynein heavy chain 12-like protein) (Axonemal dynein heavy chain 7-like protein) (Ciliary dynein heavy chain 12)" Dnah12 Dnah12l Dnah7l Dnahc12 Dnahc7l Mus musculus (Mouse) TR23609_c2_g1_i1 H2A0L0 TYRO1_PINMG 4.00E-18 GO:0005576; GO:0046872; GO:0016491 extracellular region; metal ion binding; oxidoreductase activity IPR002227; IPR008922; Tyrosinase-like protein 1 (EC 1.14.18.-) (Tyrosinase 1) Pinctada margaritifera (Black-lipped pearl oyster) TR23611_c0_g1_i1 Q9ULJ7 ANR50_HUMAN 2.00E-34 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) TR23611_c0_g1_i2 A2AS55 ANR16_MOUSE 1.00E-93 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 16 Ankrd16 Mus musculus (Mouse) TR23611_c0_g1_i3 A2AS55 ANR16_MOUSE 1.00E-93 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 16 Ankrd16 Mus musculus (Mouse) TR23612_c0_g1_i1 B5X7X4 LTOR2_SALSA 1.00E-51 GO:0071986; GO:0016049; GO:0034613; GO:0071230; GO:0005765; GO:0032008 Ragulator complex; cell growth; cellular protein localization; cellular response to amino acid stimulus; lysosomal membrane; positive regulation of TOR signaling cascade IPR004942; Ragulator complex protein LAMTOR2 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) lamtor2 Salmo salar (Atlantic salmon) TR23616_c1_g1_i1 Q9XSZ4 S4A4_RABIT 1.00E-29 GO:0016323; GO:0005452; GO:0016021; GO:0006814; GO:0015293 basolateral plasma membrane; inorganic anion exchanger activity; integral to membrane; sodium ion transport; symporter activity IPR013769; IPR011531; IPR003020; IPR003024; IPR016152; Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) SLC4A4 NBC1 NBCE1 Oryctolagus cuniculus (Rabbit) TR23620_c1_g1_i1 Q8N5Z5 KCD17_HUMAN 5.00E-07 GO:0051260 Itself; Q9H5I1 protein homooligomerization IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein KCTD17 KCTD17 Homo sapiens (Human) TR23620_c3_g1_i1 P16389 KCNA2_HUMAN 9.00E-43 GO:0005251; GO:0044224; GO:0021633; GO:0015271; GO:0051260; GO:0007268; GO:0008076 delayed rectifier potassium channel activity; juxtaparanode region of axon; optic nerve structural organization; outward rectifier potassium channel activity; protein homooligomerization; synaptic transmission; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003972; IPR004049; IPR003131; IPR028325; Potassium voltage-gated channel subfamily A member 2 (NGK1) (Voltage-gated K(+) channel HuKIV) (Voltage-gated potassium channel HBK5) (Voltage-gated potassium channel subunit Kv1.2) KCNA2 Homo sapiens (Human) TR23621_c1_g1_i1 Q1LZA4 PIGW_BOVIN 2.00E-27 GO:0006506; GO:0005789; GO:0016021; GO:0016746 "GPI anchor biosynthetic process; endoplasmic reticulum membrane; integral to membrane; transferase activity, transferring acyl groups" IPR009447; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Phosphatidylinositol-glycan biosynthesis class W protein (PIG-W) (EC 2.3.-.-) PIGW Bos taurus (Bovine) TR23621_c1_g2_i1 Q754I2 GWT1_ASHGO 2.00E-18 GO:0006506; GO:0005789; GO:0032216; GO:0016021 GPI anchor biosynthetic process; endoplasmic reticulum membrane; glucosaminyl-phosphotidylinositol O-acyltransferase activity; integral to membrane IPR009447; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. GPI-anchored wall transfer protein 1 (EC 2.3.-.-) GWT1 AFR094C Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR23626_c0_g1_i2 P80226 FABPL_CHICK 5.00E-14 GO:0005737; GO:0008289; GO:0005215 cytoplasm; lipid binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; "Fatty acid-binding protein, liver (Fatty acid-binding protein 1) (Liver basic FABP) (LB-FABP) (Liver bile acid-binding protein) (L-BABP) (Liver-type fatty acid-binding protein) (L-FABP)" FABP1 Gallus gallus (Chicken) TR23629_c0_g1_i1 Q9VAU9 ZN330_DROME 9.00E-108 GO:0000775; GO:0030496; GO:0005730; GO:0008270 Q5BI51; Q9W4I5 "chromosome, centromeric region; midbody; nucleolus; zinc ion binding" IPR010531; Zinc finger protein 330 homolog (Nucleolar autoantigen 36 homolog) Noa36 CG10009 Drosophila melanogaster (Fruit fly) TR23632_c0_g1_i1 Q91837 FASC_XENLA 9.00E-08 GO:0015629; GO:0030036; GO:0051015; GO:0005737 actin cytoskeleton; actin cytoskeleton organization; actin filament binding; cytoplasm IPR008999; IPR010431; IPR022768; IPR024703; Fascin fscn Xenopus laevis (African clawed frog) TR23633_c8_g2_i1 Q9Z2I7 SVOP_RAT 4.00E-11 GO:0030054; GO:0016021; GO:0015075; GO:0008021; GO:0030672 cell junction; integral to membrane; ion transmembrane transporter activity; synaptic vesicle; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; IPR004749; IPR005828; Synaptic vesicle 2-related protein (SV2-related protein) Svop Rattus norvegicus (Rat) TR23636_c2_g1_i1 O97507 FA12_PIG 2.00E-11 GO:0007596; GO:0005615; GO:0042730; GO:0006508; GO:0004252 blood coagulation; extracellular space; fibrinolysis; proteolysis; serine-type endopeptidase activity IPR014394; IPR000742; IPR013032; IPR000083; IPR000562; IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR009003; Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Coagulation factor XIIa light chain] F12 Sus scrofa (Pig) TR23636_c3_g2_i1 P26928 HGFL_MOUSE 5.00E-18 GO:0007566; GO:0005576; GO:0006508; GO:0004252 embryo implantation; extracellular region; proteolysis; serine-type endopeptidase activity IPR024174; IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR001254; IPR001314; IPR009003; Hepatocyte growth factor-like protein (Macrophage stimulatory protein) (MSP) [Cleaved into: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain] Mst1 Hgfl Mus musculus (Mouse) TR23636_c4_g1_i1 P06868 PLMN_BOVIN 8.00E-20 GO:0007596; GO:0005576; GO:0042730; GO:0006508; GO:0004252; GO:0048771 blood coagulation; extracellular region; fibrinolysis; proteolysis; serine-type endopeptidase activity; tissue remodeling IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Bos taurus (Bovine) TR23636_c4_g2_i1 P06868 PLMN_BOVIN 8.00E-19 GO:0007596; GO:0005576; GO:0042730; GO:0006508; GO:0004252; GO:0048771 blood coagulation; extracellular region; fibrinolysis; proteolysis; serine-type endopeptidase activity; tissue remodeling IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Bos taurus (Bovine) TR23636_c5_g1_i1 P60756 MDGA2_RAT 1.00E-10 GO:0031225; GO:0005886; GO:0021522 anchored to membrane; plasma membrane; spinal cord motor neuron differentiation IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 2 (MAM domain-containing protein 1) Mdga2 Mamdc1 Rattus norvegicus (Rat) TR23638_c2_g1_i1 P06144 H1_LYTPI 1.00E-09 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR005818; IPR005819; IPR011991; Late histone H1 Lytechinus pictus (Painted sea urchin) TR23638_c2_g1_i2 Q05831 H1L_MYTTR 1.00E-46 GO:0003677; GO:0030154; GO:0030261; GO:0007275; GO:0000786; GO:0006334; GO:0005634; GO:0007283 DNA binding; cell differentiation; chromosome condensation; multicellular organismal development; nucleosome; nucleosome assembly; nucleus; spermatogenesis IPR005818; IPR005819; IPR011991; Sperm-specific protein PHI-2B/PHI-3 [Cleaved into: Sperm-specific protein PHI-2B (PL-II*) (Sperm-specific linker histone H1-like protein); Sperm-specific protein PHI-3 (PL-IV) (Protamine-like protein PHI-3)] Mytilus trossulus (Blue mussel) TR23639_c0_g1_i1 P49951 CLHC1_BOVIN 2.00E-35 GO:0030132; GO:0030130; GO:0006886; GO:0042470; GO:0030117; GO:0005739; GO:0005198; GO:0016192 Itself clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; intracellular protein transport; melanosome; membrane coat; mitochondrion; structural molecule activity; vesicle-mediated transport IPR016024; IPR000547; IPR016025; IPR015348; IPR001473; IPR022365; IPR016341; IPR011990; Clathrin heavy chain 1 CLTC Bos taurus (Bovine) TR23639_c1_g1_i1 Q9U7D1 H3_MASBA 5.00E-08 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR000164; Histone H3 Mastigamoeba balamuthi (Phreatamoeba balamuthi) TR23639_c2_g1_i1 Q10161 CLH_SCHPO 1.00E-26 GO:0030132; GO:0030130; GO:0005737; GO:0006897; GO:0006886; GO:0005198 clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; cytoplasm; endocytosis; intracellular protein transport; structural molecule activity IPR016024; IPR000547; IPR016025; IPR015348; IPR001473; IPR022365; IPR016341; IPR011990; Probable clathrin heavy chain chc1 SPAC26A3.05 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR23641_c0_g1_i1 Q96I82 KAZD1_HUMAN 6.00E-39 GO:0030154; GO:0030198; GO:0005614; GO:0007275; GO:0001503; GO:0001558 cell differentiation; extracellular matrix organization; interstitial matrix; multicellular organismal development; ossification; regulation of cell growth IPR009030; IPR007110; IPR013783; IPR013098; IPR003598; IPR000867; IPR011390; IPR002350; Kazal-type serine protease inhibitor domain-containing protein 1 KAZALD1 FKSG28 FKSG40 UNQ2945/PRO21184 Homo sapiens (Human) TR23647_c1_g1_i1 Q01797 ESCA_CALVI 7.00E-08 GO:0003677; GO:0046872; GO:0005634 DNA binding; metal ion binding; nucleus IPR007087; IPR015880; IPR013087; Escargot/snail protein homolog (Fragment) Calliphora vicina (Blue blowfly) (Calliphora erythrocephala) TR23647_c1_g1_i2 Q13360 ZN177_HUMAN 9.00E-23 GO:0003677; GO:0046872; GO:0000122; GO:0005634; GO:0006351 "DNA binding; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 177 ZNF177 Homo sapiens (Human) TR23651_c2_g1_i2 Q96MM6 HS12B_HUMAN 4.00E-14 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR23653_c0_g1_i1 Q5VUM1 CF057_HUMAN 2.00E-18 GO:0005576; GO:0005739 extracellular region; mitochondrion IPR012875; UPF0369 protein C6orf57 C6orf57 Homo sapiens (Human) TR23654_c2_g1_i1 Q96DY7 MTBP_HUMAN 3.00E-11 GO:0007050; GO:0008285; GO:0007089 cell cycle arrest; negative regulation of cell proliferation; traversing start control point of mitotic cell cycle Mdm2-binding protein (hMTBP) MTBP Homo sapiens (Human) TR23654_c2_g1_i2 Q0P4G8 MTBP_XENTR 6.00E-13 GO:0007050 cell cycle arrest Mdm2-binding protein mtbp Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR23657_c1_g1_i1 P01041 CYTB_RAT 3.00E-23 GO:0008344; GO:0004869; GO:0005737; GO:0005730; GO:0042981 adult locomotory behavior; cysteine-type endopeptidase inhibitor activity; cytoplasm; nucleolus; regulation of apoptotic process IPR000010; IPR018073; IPR001713; Cystatin-B (Cystatin-beta) (Liver thiol proteinase inhibitor) (Stefin-B) Cstb Cst6 Rattus norvegicus (Rat) TR23663_c4_g1_i1 Q9UBT6 POLK_HUMAN 4.00E-15 GO:0006281; GO:0006260; GO:0003887; GO:0003684; GO:0046872; GO:0006297; GO:0005634 "DNA repair; DNA replication; DNA-directed DNA polymerase activity; damaged DNA binding; metal ion binding; nucleotide-excision repair, DNA gap filling; nucleus" IPR017961; IPR001126; IPR017963; IPR022880; IPR024728; IPR006642; DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP) POLK DINB1 Homo sapiens (Human) TR23665_c4_g1_i1 O73791 TIE2_DANRE 6.00E-07 GO:0005524; GO:0005737; GO:0005856; GO:0005925; GO:0007507; GO:0005887; GO:0018108; GO:0004714; GO:0007169 ATP binding; cytoplasm; cytoskeleton; focal adhesion; heart development; integral to plasma membrane; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000742; IPR013032; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR011009; IPR000719; IPR017441; IPR001245; IPR018941; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-2 (EC 2.7.10.1) (Tyrosine kinase with Ig and EGF homology domains-2) tie2 tie-2 Danio rerio (Zebrafish) (Brachydanio rerio) TR23667_c2_g1_i1 Q92870 APBB2_HUMAN 8.00E-46 GO:0007411; GO:0001540; GO:0007050; GO:0005737; GO:0030198; GO:0030426; GO:0035556; GO:0030027; GO:0016020; GO:0043066; GO:0030308; GO:0001764; GO:0005634; GO:0043065; GO:0006355; GO:0045202; GO:0008134 P05067; P00533 "axon guidance; beta-amyloid binding; cell cycle arrest; cytoplasm; extracellular matrix organization; growth cone; intracellular signal transduction; lamellipodium; membrane; negative regulation of apoptotic process; negative regulation of cell growth; neuron migration; nucleus; positive regulation of apoptotic process; regulation of transcription, DNA-dependent; synapse; transcription factor binding" IPR011993; IPR006020; IPR001202; Amyloid beta A4 precursor protein-binding family B member 2 (Protein Fe65-like 1) APBB2 FE65L FE65L1 Homo sapiens (Human) TR23668_c0_g2_i1 Q8H038 KATAM_ORYSJ 9.00E-13 GO:0032580; GO:0016021; GO:0006486; GO:0016757 "Golgi cisterna membrane; integral to membrane; protein glycosylation; transferase activity, transferring glycosyl groups" IPR004263; Protein modification; protein glycosylation. Xyloglucan galactosyltransferase KATAMARI1 homolog (EC 2.4.1.-) Os03g0144800 LOC_Os03g05110 OJ1172F09.5 Oryza sativa subsp. japonica (Rice) TR23671_c2_g1_i1 A2A935 PRD16_MOUSE 7.00E-06 GO:0050873; GO:0046872; GO:0030853; GO:0000122; GO:0030512; GO:0022008; GO:0060021; GO:0045893; GO:0043457; GO:0043565; GO:0035019; GO:0043586; GO:0003713; GO:0006351; GO:0017053; GO:0050872 "brown fat cell differentiation; metal ion binding; negative regulation of granulocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; neurogenesis; palate development; positive regulation of transcription, DNA-dependent; regulation of cellular respiration; sequence-specific DNA binding; somatic stem cell maintenance; tongue development; transcription coactivator activity; transcription, DNA-dependent; transcriptional repressor complex; white fat cell differentiation" IPR001214; IPR007087; IPR015880; IPR013087; PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) Prdm16 Kiaa1675 Mel1 Mus musculus (Mouse) TR23671_c2_g2_i1 P15619 SRYC_DROME 5.00E-07 GO:0003677; GO:0046872; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Serendipity locus protein H-1 (Protein pourquoi-pas) (Protein wings-down) wdn pqp sry h-1 Sry-c CG1454 Drosophila melanogaster (Fruit fly) TR23672_c0_g1_i1 O43301 HS12A_HUMAN 2.00E-17 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR23672_c2_g1_i1 Q96MM6 HS12B_HUMAN 2.00E-12 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR23678_c0_g1_i1 Q63170 DYH7_RAT 9.00E-20 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0005509; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; calcium ion binding; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR026983; IPR026979; IPR024743; IPR024317; IPR004273; IPR013602; IPR018247; IPR002048; IPR027417; "Dynein heavy chain 7, axonemal (Axonemal beta dynein heavy chain 7) (Axonemal dynein heavy chain b) (Ciliary dynein heavy chain 7) (Dynein-like protein 7)" Dnah7 Axob Dlp7 Rattus norvegicus (Rat) TR23678_c0_g2_i1 P39057 DYHC_ANTCR 5.00E-72 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein beta chain, ciliary" Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR23678_c1_g1_i1 Q8WXX0 DYH7_HUMAN 8.00E-35 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0005509; GO:0001539; GO:0005929; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; calcium ion binding; ciliary or bacterial-type flagellar motility; cilium; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR026983; IPR026979; IPR024743; IPR024317; IPR004273; IPR013602; IPR018247; IPR002048; IPR027417; "Dynein heavy chain 7, axonemal (Axonemal beta dynein heavy chain 7) (Ciliary dynein heavy chain 7) (Dynein heavy chain-like protein 2) (hDHC2)" DNAH7 KIAA0944 Homo sapiens (Human) TR23678_c1_g2_i1 Q27802 DYHC2_TRIGR 1.00E-18 GO:0005524; GO:0006200; GO:0016887; GO:0030031; GO:0001539; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018; GO:0007275; GO:0005886 ATP binding; ATP catabolic process; ATPase activity; cell projection assembly; ciliary or bacterial-type flagellar motility; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement; multicellular organismal development; plasma membrane IPR003593; IPR011704; IPR026983; IPR026815; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; Cytoplasmic dynein 2 heavy chain 1 (Dynein heavy chain isotype 1B) DYH1B Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla) TR23678_c3_g1_i1 P39057 DYHC_ANTCR 3.00E-119 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein beta chain, ciliary" Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR23679_c2_g1_i1 Q6GLJ0 MFN2A_XENLA 1.00E-27 GO:0016021; GO:0006811; GO:0055072; GO:0005743 integral to membrane; ion transport; iron ion homeostasis; mitochondrial inner membrane IPR018108; IPR023395; Mitoferrin-2A (Mitochondrial iron transporter 2-A) (Solute carrier family 25 member 28-A) slc25a28-a mfrn2-a Xenopus laevis (African clawed frog) TR23683_c0_g1_i1 Q13158 FADD_HUMAN 1.00E-07 GO:0031265; GO:0035666; GO:0006919; GO:0044297; GO:0071260; GO:0005829; GO:0005123; GO:0051607; GO:0008625; GO:0045087; GO:0045121; GO:0019048; GO:0070265; GO:0043005; GO:0043123; GO:0043065; GO:2001238; GO:0032757; GO:0045862; GO:0045944; GO:0032760; GO:0060340; GO:0051291; GO:2001239; GO:0097342; GO:0034138; GO:0034142 Itself; Q14790; Q14790-1; Q14790-5; P25445; P25446; P48023; Q5S007; O95243; Q99836; Q99497; P53350; Q13546 CD95 death-inducing signaling complex; TRIF-dependent toll-like receptor signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; cell body; cellular response to mechanical stimulus; cytosol; death receptor binding; defense response to virus; extrinsic apoptotic signaling pathway via death domain receptors; innate immune response; membrane raft; modulation by virus of host morphology or physiology; necrotic cell death; neuron projection; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptotic process; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of interleukin-8 production; positive regulation of proteolysis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; positive regulation of type I interferon-mediated signaling pathway; protein heterooligomerization; regulation of extrinsic apoptotic signaling pathway in absence of ligand; ripoptosome; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway IPR011029; IPR000488; IPR001875; IPR016729; Protein FADD (FAS-associated death domain protein) (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity) FADD MORT1 GIG3 Homo sapiens (Human) TR23683_c0_g1_i2 Q14790 CASP8_HUMAN 2.00E-07 GO:0031265; GO:0030690; GO:0035666; GO:0006919; GO:0001525; GO:0044297; GO:0006921; GO:0071260; GO:0005813; GO:0097153; GO:0005829; GO:0031264; GO:0097191; GO:0007507; GO:0045087; GO:0097193; GO:0030225; GO:0045121; GO:0005741; GO:0019048; GO:0043124; GO:0001841; GO:0043005; GO:0070423; GO:0005634; GO:0043123; GO:0045651; GO:1900740; GO:0045862; GO:0051291; GO:0051603; GO:2001239; GO:0046677; GO:0032025; GO:0009409; GO:0032355; GO:0045471; GO:0032496; GO:0034612; GO:0097342; GO:0034138; GO:0034142 P51572; Q92851; Q9UKL3; O15519-1; Q13618; Q13158; P25445; P48023; Q13418; Q9UDY8; O60936; P29350; Q13546; O00220 CD95 death-inducing signaling complex; Noc1p-Noc2p complex; TRIF-dependent toll-like receptor signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cell body; cellular component disassembly involved in execution phase of apoptosis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; cytosol; death-inducing signaling complex; extrinsic apoptotic signaling pathway; heart development; innate immune response; intrinsic apoptotic signaling pathway; macrophage differentiation; membrane raft; mitochondrial outer membrane; modulation by virus of host morphology or physiology; negative regulation of I-kappaB kinase/NF-kappaB cascade; neural tube formation; neuron projection; nucleotide-binding oligomerization domain containing signaling pathway; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macrophage differentiation; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of proteolysis; protein heterooligomerization; proteolysis involved in cellular protein catabolic process; regulation of extrinsic apoptotic signaling pathway in absence of ligand; response to antibiotic; response to cobalt ion; response to cold; response to estradiol stimulus; response to ethanol; response to lipopolysaccharide; response to tumor necrosis factor; ripoptosome; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] CASP8 MCH5 Homo sapiens (Human) TR23684_c0_g1_i2 Q502D1 GLOD5_DANRE 3.00E-59 IPR025870; Glyoxalase domain-containing protein 5 glod5 zgc:112315 Danio rerio (Zebrafish) (Brachydanio rerio) TR23688_c0_g1_i1 Q14114 LRP8_HUMAN 1.00E-33 GO:0021541; GO:0034185; GO:0007596; GO:0005509; GO:0005901; GO:0019221; GO:0005576; GO:0016021; GO:0021819; GO:0000122; GO:0007603; GO:0032793; GO:1900006; GO:0061003; GO:0061098; GO:0006508; GO:0038025; GO:0050804; GO:0001523; GO:0030229 "ammon gyrus development; apolipoprotein binding; blood coagulation; calcium ion binding; caveola; cytokine-mediated signaling pathway; extracellular region; integral to membrane; layer formation in cerebral cortex; negative regulation of transcription from RNA polymerase II promoter; phototransduction, visible light; positive regulation of CREB transcription factor activity; positive regulation of dendrite development; positive regulation of dendritic spine morphogenesis; positive regulation of protein tyrosine kinase activity; proteolysis; reelin receptor activity; regulation of synaptic transmission; retinoid metabolic process; very-low-density lipoprotein particle receptor activity" IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2) LRP8 APOER2 Homo sapiens (Human) TR23688_c0_g2_i1 O88572 LRP6_MOUSE 3.00E-34 GO:0044332; GO:0021874; GO:0090244; GO:0042813; GO:0090245; GO:0046849; GO:0060444; GO:0061310; GO:0061324; GO:0005901; GO:0042074; GO:0009986; GO:0071397; GO:0021587; GO:0021795; GO:0060026; GO:0015026; GO:0071936; GO:0031410; GO:0071542; GO:0005769; GO:0048596; GO:0042733; GO:0035115; GO:0035116; GO:0009880; GO:0060059; GO:0005783; GO:0035261; GO:0060325; GO:0021861; GO:0021943; GO:0001947; GO:0016021; GO:0019210; GO:0005041; GO:0060596; GO:0030901; GO:0030917; GO:0050680; GO:0045599; GO:2000151; GO:2000162; GO:2000168; GO:2000164; GO:2000166; GO:2000149; GO:0071901; GO:0034392; GO:0014029; GO:0001843; GO:0043025; GO:0042475; GO:0060021; GO:0003344; GO:2000055; GO:0043065; GO:0045780; GO:0090263; GO:0045787; GO:0002053; GO:0045778; GO:0051091; GO:0045944; GO:0036342; GO:0090009; GO:0043235; GO:0090118; GO:0060284; GO:0051593; GO:0048705; GO:0045202; GO:0007268; GO:0021794; GO:0019534; GO:0060535 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt receptor signaling pathway involved in forebrain neuroblast division; Wnt receptor signaling pathway involved in somitogenesis; Wnt-activated receptor activity; axis elongation involved in somitogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development; canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; caveola; cell migration involved in gastrulation; cell surface; cellular response to cholesterol; cerebellum morphogenesis; cerebral cortex cell migration; convergent extension; coreceptor activity; coreceptor activity involved in Wnt receptor signaling pathway; cytoplasmic vesicle; dopaminergic neuron differentiation; early endosome; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic pattern specification; embryonic retina morphogenesis in camera-type eye; endoplasmic reticulum; external genitalia morphogenesis; face morphogenesis; forebrain radial glial cell differentiation; formation of radial glial scaffolds; heart looping; integral to membrane; kinase inhibitor activity; low-density lipoprotein receptor activity; mammary placode formation; midbrain development; midbrain-hindbrain boundary development; negative regulation of epithelial cell proliferation; negative regulation of fat cell differentiation; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis; negative regulation of planar cell polarity pathway involved in neural tube closure; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest formation; neural tube closure; neuronal cell body; odontogenesis of dentin-containing tooth; palate development; pericardium morphogenesis; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell cycle; positive regulation of mesenchymal cell proliferation; positive regulation of ossification; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; post-anal tail morphogenesis; primitive streak formation; receptor complex; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport; regulation of cell development; response to folic acid; skeletal system morphogenesis; synapse; synaptic transmission; thalamus development; toxin transporter activity; trachea cartilage morphogenesis IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 6 (LRP-6) Lrp6 Mus musculus (Mouse) TR23690_c0_g1_i1 Q0VCH8 TMM65_BOVIN 4.00E-57 GO:0016021; GO:0005739 integral to membrane; mitochondrion IPR019537; Transmembrane protein 65 TMEM65 Bos taurus (Bovine) TR23691_c3_g1_i1 P28739 KLPA_EMENI 7.00E-74 GO:0005524; GO:0000235; GO:0005871; GO:0007019; GO:0007018; GO:0008569; GO:0008574; GO:0090307 ATP binding; astral microtubule; kinesin complex; microtubule depolymerization; microtubule-based movement; minus-end-directed microtubule motor activity; plus-end-directed microtubule motor activity; spindle assembly involved in mitosis IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein klpA klpA AN6340 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR23691_c5_g1_i1 P56536 KIF5C_RAT 3.00E-14 GO:0005524; GO:0005737; GO:0005871; GO:0051028; GO:0005874; GO:0003777; GO:0007018 Q8IXI2 ATP binding; cytoplasm; kinesin complex; mRNA transport; microtubule; microtubule motor activity; microtubule-based movement IPR027640; IPR019821; IPR001752; IPR027417; Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2) (Fragment) Kif5c Nkhc2 Rattus norvegicus (Rat) TR23692_c0_g1_i1 P0CW97 PCR3_ARATH 1.00E-09 GO:0016021 integral to membrane IPR006461; Protein PLANT CADMIUM RESISTANCE 3 (AtPCR3) PCR3 At5g35525 MOK9 Arabidopsis thaliana (Mouse-ear cress) TR23693_c0_g1_i1 P23403 RS20_XENLA 2.00E-71 GO:0003723; GO:0015935; GO:0003735; GO:0006412 RNA binding; small ribosomal subunit; structural constituent of ribosome; translation IPR001848; IPR018268; IPR027486; IPR005729; 40S ribosomal protein S20 (S22) rps20 Xenopus laevis (African clawed frog) TR23695_c0_g1_i1 Q97AU0 Y719_THEVO 8.00E-07 IPR002589; Uncharacterized protein TV0719 TV0719 TVG0726109 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) TR23695_c1_g1_i1 Q9NR21 PAR11_HUMAN 7.00E-07 GO:0003950 NAD+ ADP-ribosyltransferase activity IPR012317; IPR004170; Poly [ADP-ribose] polymerase 11 (PARP-11) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 11) (ARTD11) PARP11 C12orf6 Homo sapiens (Human) TR23695_c1_g1_i2 O95271 TNKS1_HUMAN 9.00E-11 GO:0005794; GO:0000139; GO:0003950; GO:0016055; GO:0051301; GO:0000775; GO:0051028; GO:0007067; GO:0007052; GO:0043392; GO:0000784; GO:0031965; GO:0005643; GO:0018105; GO:0018107; GO:0000242; GO:0090263; GO:0032212; GO:0045944; GO:0070213; GO:0070198; GO:0070212; GO:0000209; GO:0015031; GO:0051225; GO:0000922; GO:0008270 O35625; Q9HC77; Q96RU3; Q9NWT6 "Golgi apparatus; Golgi membrane; NAD+ ADP-ribosyltransferase activity; Wnt receptor signaling pathway; cell division; chromosome, centromeric region; mRNA transport; mitosis; mitotic spindle organization; negative regulation of DNA binding; nuclear chromosome, telomeric region; nuclear membrane; nuclear pore; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pericentriolar material; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of telomere maintenance via telomerase; positive regulation of transcription from RNA polymerase II promoter; protein auto-ADP-ribosylation; protein localization to chromosome, telomeric region; protein poly-ADP-ribosylation; protein polyubiquitination; protein transport; spindle assembly; spindle pole; zinc ion binding" IPR002110; IPR020683; IPR012317; IPR001660; IPR013761; IPR011510; Tankyrase-1 (TANK1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) TNKS PARP5A PARPL TIN1 TINF1 TNKS1 Homo sapiens (Human) TR23696_c0_g1_i2 Q8VE09 TT39C_MOUSE 2.00E-09 IPR019412; IPR011990; Tetratricopeptide repeat protein 39C (TPR repeat protein 39C) Ttc39c Mus musculus (Mouse) TR23696_c1_g1_i1 Q0VGK2 TT39C_RAT 1.00E-06 IPR019412; IPR011990; Tetratricopeptide repeat protein 39C (TPR repeat protein 39C) Ttc39c Rattus norvegicus (Rat) TR23697_c4_g1_i1 A2ASS6 TITIN_MOUSE 3.00E-06 GO:0005524; GO:0031430; GO:0030018; GO:0007512; GO:0055003; GO:0043056; GO:0003007; GO:0001701; GO:0046872; GO:0006936; GO:0005859; GO:0005634; GO:0018108; GO:0004674; GO:0004713; GO:1901897; GO:0045214; GO:0001756; GO:0005200 ATP binding; M band; Z disc; adult heart development; cardiac myofibril assembly; forward locomotion; heart morphogenesis; in utero embryonic development; metal ion binding; muscle contraction; muscle myosin complex; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of relaxation of cardiac muscle; sarcomere organization; somitogenesis; structural constituent of cytoskeleton IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) TR23697_c4_g1_i2 Q92626 PXDN_HUMAN 7.00E-09 GO:0005783; GO:0031012; GO:0030198; GO:0005201; GO:0005615; GO:0020037; GO:0042744; GO:0006955; GO:0005152; GO:0046872; GO:0004601; GO:0005578 endoplasmic reticulum; extracellular matrix; extracellular matrix organization; extracellular matrix structural constituent; extracellular space; heme binding; hydrogen peroxide catabolic process; immune response; interleukin-1 receptor antagonist activity; metal ion binding; peroxidase activity; proteinaceous extracellular matrix IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; IPR001007; Peroxidasin homolog (EC 1.11.1.7) (Melanoma-associated antigen MG50) (Vascular peroxidase 1) (p53-responsive gene 2 protein) PXDN KIAA0230 MG50 PRG2 VPO VPO1 Homo sapiens (Human) TR23699_c2_g1_i1 Q8AYS7 CENPI_CHICK 3.00E-46 GO:0034508; GO:0000776; GO:0005634 centromere complex assembly; kinetochore; nucleus IPR012485; Centromere protein I (CENP-I) CENPI Gallus gallus (Chicken) TR23702_c2_g1_i1 Q6ZN19 ZN841_HUMAN 4.00E-21 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 841 ZNF841 Homo sapiens (Human) TR23702_c2_g1_i2 Q6ZN19 ZN841_HUMAN 2.00E-22 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 841 ZNF841 Homo sapiens (Human) TR23702_c3_g1_i1 P41995 ODD1_CAEEL 5.00E-12 GO:0003677; GO:0046872; GO:0007275; GO:0005634 DNA binding; metal ion binding; multicellular organismal development; nucleus IPR007087; IPR015880; IPR013087; Zinc finger protein odd-1 odd-1 B0280.4 Caenorhabditis elegans TR23705_c3_g2_i1 Q13263 TIF1B_HUMAN 6.00E-12 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR23709_c1_g1_i1 Q5U206 CALL3_RAT 5.00E-16 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-like protein 3 Calml3 Rattus norvegicus (Rat) TR23711_c2_g2_i1 A2AX52 CO6A4_MOUSE 5.00E-14 GO:0007155; GO:0005581; GO:0005576; GO:0043234; GO:0070208 cell adhesion; collagen; extracellular region; protein complex; protein heterotrimerization IPR008160; IPR002035; Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) TR23711_c2_g4_i1 Q99715 COCA1_HUMAN 4.00E-10 GO:0007155; GO:0030574; GO:0030199; GO:0005595; GO:0005788; GO:0022617; GO:0030020; GO:0005615; GO:0070062; GO:0001501 cell adhesion; collagen catabolic process; collagen fibril organization; collagen type XII; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular matrix structural constituent conferring tensile strength; extracellular space; extracellular vesicular exosome; skeletal system development IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) TR23716_c0_g1_i1 Q9QUK3 CLN8_MOUSE 2.00E-56 GO:0051935; GO:0007628; GO:0001306; GO:0008306; GO:0008219; GO:0044257; GO:0006672; GO:0008203; GO:0005783; GO:0005789; GO:0005793; GO:0033116; GO:0016021; GO:0007040; GO:0007006; GO:0050881; GO:0043066; GO:0051348; GO:0060052; GO:0050885; GO:0050884; GO:0006644; GO:0045494; GO:0008361; GO:0060041; GO:0035176; GO:0021523; GO:0007601 L-glutamate uptake involved in synaptic transmission; adult walking behavior; age-dependent response to oxidative stress; associative learning; cell death; cellular protein catabolic process; ceramide metabolic process; cholesterol metabolic process; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; lysosome organization; mitochondrial membrane organization; musculoskeletal movement; negative regulation of apoptotic process; negative regulation of transferase activity; neurofilament cytoskeleton organization; neuromuscular process controlling balance; neuromuscular process controlling posture; phospholipid metabolic process; photoreceptor cell maintenance; regulation of cell size; retina development in camera-type eye; social behavior; somatic motor neuron differentiation; visual perception IPR006634; Protein CLN8 Cln8 Mus musculus (Mouse) TR23716_c0_g1_i2 Q9QUK3 CLN8_MOUSE 6.00E-56 GO:0051935; GO:0007628; GO:0001306; GO:0008306; GO:0008219; GO:0044257; GO:0006672; GO:0008203; GO:0005783; GO:0005789; GO:0005793; GO:0033116; GO:0016021; GO:0007040; GO:0007006; GO:0050881; GO:0043066; GO:0051348; GO:0060052; GO:0050885; GO:0050884; GO:0006644; GO:0045494; GO:0008361; GO:0060041; GO:0035176; GO:0021523; GO:0007601 L-glutamate uptake involved in synaptic transmission; adult walking behavior; age-dependent response to oxidative stress; associative learning; cell death; cellular protein catabolic process; ceramide metabolic process; cholesterol metabolic process; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; lysosome organization; mitochondrial membrane organization; musculoskeletal movement; negative regulation of apoptotic process; negative regulation of transferase activity; neurofilament cytoskeleton organization; neuromuscular process controlling balance; neuromuscular process controlling posture; phospholipid metabolic process; photoreceptor cell maintenance; regulation of cell size; retina development in camera-type eye; social behavior; somatic motor neuron differentiation; visual perception IPR006634; Protein CLN8 Cln8 Mus musculus (Mouse) TR23726_c0_g1_i1 P07796 H1G_STRPU 1.00E-07 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR005818; IPR005819; IPR011991; "Histone H1-gamma, late" Strongylocentrotus purpuratus (Purple sea urchin) TR23727_c3_g2_i1 P07602 SAP_HUMAN 2.00E-14 GO:0005794; GO:0071310; GO:0008047; GO:0060742; GO:0005615; GO:0006687; GO:0016021; GO:0008289; GO:0006869; GO:0043202; GO:0005765; GO:0005739; GO:0030168; GO:0002576; GO:0060736; GO:0043408; GO:0019216; GO:0044281 Golgi apparatus; cellular response to organic substance; enzyme activator activity; epithelial cell differentiation involved in prostate gland development; extracellular space; glycosphingolipid metabolic process; integral to membrane; lipid binding; lipid transport; lysosomal lumen; lysosomal membrane; mitochondrion; platelet activation; platelet degranulation; prostate gland growth; regulation of MAPK cascade; regulation of lipid metabolic process; small molecule metabolic process IPR003119; IPR007856; IPR008138; IPR008373; IPR011001; IPR021165; IPR008139; Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)] PSAP GLBA SAP1 Homo sapiens (Human) TR23738_c0_g1_i1 Q66HG4 GALM_RAT 3.00E-44 GO:0004034; GO:0030246; GO:0005737; GO:0019318 aldose 1-epimerase activity; carbohydrate binding; cytoplasm; hexose metabolic process IPR018052; IPR015443; IPR008183; IPR011013; IPR014718; Carbohydrate metabolism; hexose metabolism. Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase) Galm Rattus norvegicus (Rat) TR23741_c1_g1_i1 Q5R5H1 METK2_PONAB 2.00E-119 GO:0005524; GO:0006556; GO:0046872; GO:0004478; GO:0006730 ATP binding; S-adenosylmethionine biosynthetic process; metal ion binding; methionine adenosyltransferase activity; one-carbon metabolic process IPR022631; IPR022630; IPR022629; IPR022628; IPR002133; IPR022636; Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) MAT2A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR23741_c2_g2_i1 P31156 METK2_PETCR 1.00E-14 GO:0005524; GO:0006556; GO:0005737; GO:0046872; GO:0004478; GO:0006730 ATP binding; S-adenosylmethionine biosynthetic process; cytoplasm; metal ion binding; methionine adenosyltransferase activity; one-carbon metabolic process IPR022631; IPR022630; IPR002133; IPR022636; Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. S-adenosylmethionine synthase 2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Fragment) SMS-2 Petroselinum crispum (Parsley) (Petroselinum hortense) TR23742_c0_g1_i1 Q06055 AT5G2_HUMAN 3.00E-21 GO:0015991; GO:0015986; GO:0015078; GO:0016021; GO:0008289; GO:0005753; GO:0045263; GO:0045471; GO:0005215 "ATP hydrolysis coupled proton transport; ATP synthesis coupled proton transport; hydrogen ion transmembrane transporter activity; integral to membrane; lipid binding; mitochondrial proton-transporting ATP synthase complex; proton-transporting ATP synthase complex, coupling factor F(o); response to ethanol; transporter activity" IPR000454; IPR020537; IPR002379; "ATP synthase F(0) complex subunit C2, mitochondrial (ATP synthase lipid-binding protein) (ATP synthase proteolipid P2) (ATP synthase proton-transporting mitochondrial F(0) complex subunit C2) (ATPase protein 9) (ATPase subunit c)" ATP5G2 PSEC0033 Homo sapiens (Human) TR23743_c0_g1_i1 Q99M03 RWD2B_MOUSE 7.00E-65 IPR010541; IPR006575; IPR016135; IPR017359; RWD domain-containing protein 2B Rwdd2b ORF5 Mus musculus (Mouse) TR23749_c3_g1_i1 Q9P2E3 ZNFX1_HUMAN 4.00E-19 GO:0046872 metal ion binding IPR016024; IPR027417; NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) TR23750_c0_g1_i1 Q54T02 ABCGO_DICDI 2.00E-33 GO:0005524; GO:0006200; GO:0016887; GO:0031154; GO:0016021; GO:0031288; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; culmination involved in sorocarp development; integral to membrane; sorocarp morphogenesis; transport IPR003593; IPR013525; IPR003439; IPR017871; IPR013032; IPR027417; ABC transporter G family member 24 (ABC transporter ABCG.24) abcG24 DDB_G0282103 Dictyostelium discoideum (Slime mold) TR23750_c2_g1_i1 Q5MB13 ABCG2_MACMU 2.00E-49 GO:0005524; GO:0006200; GO:0016887; GO:0016021; GO:0005886; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; integral to membrane; plasma membrane; transport IPR003593; IPR013525; IPR003439; IPR027417; ATP-binding cassette sub-family G member 2 (Urate exporter) (CD antigen CD338) ABCG2 Macaca mulatta (Rhesus macaque) TR23750_c2_g3_i1 Q08409 AUS1_YEAST 1.00E-13 GO:0005524; GO:0016021; GO:0005886; GO:0035376; GO:0034041 ATP binding; integral to membrane; plasma membrane; sterol import; sterol-transporting ATPase activity IPR003593; IPR013525; IPR003439; IPR017871; IPR027417; IPR010929; ATP-dependent permease AUS1 AUS1 YOR011W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR23752_c1_g1_i1 Q29RU9 SOX_BOVIN 2.00E-14 GO:0033514; GO:0050031; GO:0005777; GO:0008115; GO:0046653 L-lysine catabolic process to acetyl-CoA via L-pipecolate; L-pipecolate oxidase activity; peroxisome; sarcosine oxidase activity; tetrahydrofolate metabolic process IPR006076; IPR006281; Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase) PIPOX Bos taurus (Bovine) TR23752_c2_g1_i1 P23342 MSOX_BACSN 9.00E-11 GO:0005737; GO:0008115; GO:0046653 cytoplasm; sarcosine oxidase activity; tetrahydrofolate metabolic process IPR006076; IPR006281; Monomeric sarcosine oxidase (MSOX) (EC 1.5.3.1) soxA Bacillus sp. (strain NS-129) TR23755_c0_g1_i1 Q6PBT5 PYRD1_DANRE 0 GO:0016491 oxidoreductase activity IPR013027; IPR023753; Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 (EC 1.8.1.-) pyroxd1 zgc:73254 Danio rerio (Zebrafish) (Brachydanio rerio) TR23755_c0_g1_i2 Q5JGP4 CDR_PYRKO 3.00E-09 GO:0050451; GO:0050661; GO:0045454; GO:0050660; GO:0003756; GO:0006457 CoA-disulfide reductase activity; NADP binding; cell redox homeostasis; flavin adenine dinucleotide binding; protein disulfide isomerase activity; protein folding IPR017758; IPR016156; IPR013027; IPR004099; IPR023753; IPR001327; Coenzyme A disulfide reductase (CoA-disulfide reductase) (CoADR) (EC 1.8.1.14) TK1299 Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) TR23755_c0_g1_i3 Q6PBT5 PYRD1_DANRE 0 GO:0016491 oxidoreductase activity IPR013027; IPR023753; Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 (EC 1.8.1.-) pyroxd1 zgc:73254 Danio rerio (Zebrafish) (Brachydanio rerio) TR23757_c5_g1_i1 Q96RW7 HMCN1_HUMAN 2.00E-20 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR23760_c0_g1_i1 Q9QW30 NOTC2_RAT 6.00E-18 GO:0007219; GO:0005509; GO:0007050; GO:0001709; GO:0016049; GO:0009986; GO:0005829; GO:0005576; GO:0005887; GO:0008285; GO:0005634; GO:0009887; GO:0046579; GO:0004872; GO:0050793; GO:0006355; GO:0042246; GO:0006351 "Notch signaling pathway; calcium ion binding; cell cycle arrest; cell fate determination; cell growth; cell surface; cytosol; extracellular region; integral to plasma membrane; negative regulation of cell proliferation; nucleus; organ morphogenesis; positive regulation of Ras protein signal transduction; receptor activity; regulation of developmental process; regulation of transcription, DNA-dependent; tissue regeneration; transcription, DNA-dependent" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022336; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 2 (Notch 2) [Cleaved into: Notch 2 extracellular truncation; Notch 2 intracellular domain] Notch2 Rattus norvegicus (Rat) TR23760_c0_g1_i2 P10079 FBP1_STRPU 7.00E-22 GO:0032579; GO:0005509; GO:0016023; GO:0005615 apical lamina of hyaline layer; calcium ion binding; cytoplasmic membrane-bounded vesicle; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) TR23763_c0_g1_i1 Q95KL9 TIMP1_MACMU 7.00E-09 GO:0005604; GO:0043249; GO:0046872; GO:0008191; GO:0051045; GO:1901164 basement membrane; erythrocyte maturation; metal ion binding; metalloendopeptidase inhibitor activity; negative regulation of membrane protein ectodomain proteolysis; negative regulation of trophoblast cell migration IPR001134; IPR001820; IPR008993; IPR015611; IPR027465; Metalloproteinase inhibitor 1 (Tissue inhibitor of metalloproteinases 1) (TIMP-1) TIMP1 Macaca mulatta (Rhesus macaque) TR23765_c0_g1_i1 Q969X5 ERGI1_HUMAN 2.00E-120 GO:0006888; GO:0000139; GO:0005789; GO:0005793; GO:0033116; GO:0016021 ER to Golgi vesicle-mediated transport; Golgi membrane; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane IPR012936; Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ER-Golgi intermediate compartment 32 kDa protein) (ERGIC-32) ERGIC1 ERGIC32 KIAA1181 HT034 Homo sapiens (Human) TR23765_c0_g1_i4 Q4R8X1 ERGI3_MACFA 2.00E-30 GO:0005794; GO:0005789; GO:0033116; GO:0016021; GO:0016192 Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; vesicle-mediated transport IPR012936; Endoplasmic reticulum-Golgi intermediate compartment protein 3 ERGIC3 QtsA-11239 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR23766_c0_g1_i1 Q5XII0 EPDR1_RAT 1.00E-09 GO:0005509; GO:0007160; GO:0005576; GO:0005764 calcium ion binding; cell-matrix adhesion; extracellular region; lysosome IPR001299; Mammalian ependymin-related protein 1 (MERP-1) Epdr1 Epdr2 Merp1 Merp2 Rattus norvegicus (Rat) TR23766_c0_g1_i2 A6QLI0 EPDR1_BOVIN 3.00E-08 GO:0005509; GO:0007160; GO:0005576; GO:0005764 calcium ion binding; cell-matrix adhesion; extracellular region; lysosome IPR001299; Mammalian ependymin-related protein 1 (MERP-1) EPDR1 MERP1 Bos taurus (Bovine) TR23767_c1_g1_i1 G3V801 NETR_RAT 5.00E-24 GO:0030424; GO:0031410; GO:0030425; GO:0006887; GO:0005576; GO:0005886; GO:0006508; GO:0005044; GO:0004252; GO:0043083; GO:0043195; GO:0031638 axon; cytoplasmic vesicle; dendrite; exocytosis; extracellular region; plasma membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity; synaptic cleft; terminal bouton; zymogen activation IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR001190; IPR017448; IPR009003; Neurotrypsin (EC 3.4.21.-) (Serine protease 12) Prss12 Rattus norvegicus (Rat) TR23772_c0_g1_i1 Q9H2Y9 SO5A1_HUMAN 1.00E-55 GO:0016021; GO:0005886; GO:0005215 integral to membrane; plasma membrane; transporter activity IPR002350; IPR020846; IPR016196; IPR004156; Solute carrier organic anion transporter family member 5A1 (Organic anion transporter polypeptide-related protein 4) (OATP-RP4) (OATPRP4) (Solute carrier family 21 member 15) SLCO5A1 OATP5A1 SLC21A15 Homo sapiens (Human) TR23772_c1_g1_i1 Q9H2Y9 SO5A1_HUMAN 4.00E-52 GO:0016021; GO:0005886; GO:0005215 integral to membrane; plasma membrane; transporter activity IPR002350; IPR020846; IPR016196; IPR004156; Solute carrier organic anion transporter family member 5A1 (Organic anion transporter polypeptide-related protein 4) (OATP-RP4) (OATPRP4) (Solute carrier family 21 member 15) SLCO5A1 OATP5A1 SLC21A15 Homo sapiens (Human) TR23779_c0_g1_i1 D3Z5L6 S18B1_MOUSE 1.00E-13 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR020846; IPR016196; MFS-type transporter SLC18B1 (Solute carrier family 18 member B1) Slc18b1 Mus musculus (Mouse) TR23779_c1_g1_i1 Q6NT16 S18B1_HUMAN 5.00E-09 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR020846; IPR016196; MFS-type transporter SLC18B1 (Solute carrier family 18 member B1) SLC18B1 C6orf192 Homo sapiens (Human) TR23796_c0_g1_i4 B6LS00 U728_BRAFL 1.00E-15 IPR027885; UPF0728 protein BRAFLDRAFT_270831 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR23797_c0_g1_i1 Q07984 SSRD_RAT 6.00E-45 GO:0005784; GO:0016021 Sec61 translocon complex; integral to membrane IPR008855; Translocon-associated protein subunit delta (TRAP-delta) (Signal sequence receptor subunit delta) (SSR-delta) Ssr4 Rattus norvegicus (Rat) TR23799_c0_g1_i1 P82917 RT18C_BOVIN 2.00E-27 GO:0005763; GO:0003735; GO:0006412 mitochondrial small ribosomal subunit; structural constituent of ribosome; translation IPR001648; IPR018275; "28S ribosomal protein S18c, mitochondrial (MRP-S18-c) (Mrps18-c) (S18mt-c) (28S ribosomal protein S18-1, mitochondrial) (MRP-S18-1)" MRPS18C Bos taurus (Bovine) TR23803_c1_g1_i1 Q8K2I9 FBX18_MOUSE 3.00E-13 GO:0005524; GO:0004003; GO:0003677; GO:0005634 ATP binding; ATP-dependent DNA helicase activity; DNA binding; nucleus IPR014017; IPR000212; IPR001810; IPR027417; IPR014016; F-box only protein 18 (EC 3.6.4.12) (F-box DNA helicase 1) Fbxo18 Fbh1 Fbx18 Mus musculus (Mouse) TR23806_c0_g1_i1 Q9NX01 TXN4B_HUMAN 3.00E-71 GO:0008380; GO:0006397; GO:0007067; GO:0005681 RNA splicing; mRNA processing; mitosis; spliceosomal complex IPR004123; IPR012336; Thioredoxin-like protein 4B (Dim1-like protein) TXNL4B DIM2 DLP Homo sapiens (Human) TR23809_c0_g1_i1 Q13639 5HT4R_HUMAN 1.00E-11 GO:0007187; GO:0005737; GO:0005768; GO:0005887; GO:0008284; GO:0032098; GO:0004993; GO:0007268 "G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; cytoplasm; endosome; integral to plasma membrane; positive regulation of cell proliferation; regulation of appetite; serotonin receptor activity; synaptic transmission" IPR001520; IPR000276; IPR017452; 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) HTR4 Homo sapiens (Human) TR23809_c1_g1_i1 Q29006 5HT4R_PIG 1.00E-08 GO:0005768; GO:0005887; GO:0032098; GO:0004993; GO:0007210; GO:0007268 endosome; integral to plasma membrane; regulation of appetite; serotonin receptor activity; serotonin receptor signaling pathway; synaptic transmission IPR001520; IPR000276; IPR017452; 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) (Fragment) HTR4 Sus scrofa (Pig) TR23814_c0_g1_i1 Q5IFJ8 PSMD5_MACFA 5.00E-83 GO:0022624; GO:0006457 proteasome accessory complex; protein folding IPR019538; IPR011989; IPR016024; 26S proteasome non-ATPase regulatory subunit 5 (26S protease subunit S5 basic) (26S proteasome subunit S5B) PSMD5 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR23820_c1_g1_i1 Q8K0L0 ASB2_MOUSE 1.00E-18 GO:0031466; GO:0035556; GO:0045445; GO:0000209; GO:0016567; GO:0042787; GO:0035914 Cul5-RING ubiquitin ligase complex; intracellular signal transduction; myoblast differentiation; protein polyubiquitination; protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; skeletal muscle cell differentiation IPR002110; IPR020683; IPR001496; IPR003903; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 2 (ASB-2) Asb2 Mus musculus (Mouse) TR23820_c1_g1_i2 Q5F478 ANR44_CHICK 3.00E-27 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) TR23820_c1_g1_i3 Q8N8A2 ANR44_HUMAN 2.00E-26 Q9UPN7; P35125-3 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 Homo sapiens (Human) TR23821_c2_g2_i1 Q9H720 PG2IP_HUMAN 2.00E-21 GO:0006506; GO:0016021 GPI anchor biosynthetic process; integral to membrane IPR005135; IPR027317; PGAP2-interacting protein (Cell wall biogenesis protein 43 C-terminal homolog) CWH43 PGAP2IP Homo sapiens (Human) TR23822_c2_g1_i1 Q8VIG1 REST_MOUSE 3.00E-18 GO:0001078; GO:0060379; GO:0035690; GO:0071257; GO:0071385; GO:0003682; GO:0001047; GO:0001046; GO:0005829; GO:0070933; GO:0046872; GO:0043922; GO:0032348; GO:2000798; GO:0045955; GO:0008285; GO:2000065; GO:2000706; GO:0046676; GO:0050768; GO:0045665; GO:0005634; GO:0015271; GO:0043065; GO:0043280; GO:0045893; GO:0017053 "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; cardiac muscle cell myoblast differentiation; cellular response to drug; cellular response to electrical stimulus; cellular response to glucocorticoid stimulus; chromatin binding; core promoter binding; core promoter sequence-specific DNA binding; cytosol; histone H4 deacetylation; metal ion binding; negative regulation by host of viral transcription; negative regulation of aldosterone biosynthetic process; negative regulation of amniotic stem cell differentiation; negative regulation of calcium ion-dependent exocytosis; negative regulation of cell proliferation; negative regulation of cortisol biosynthetic process; negative regulation of dense core granule biogenesis; negative regulation of insulin secretion; negative regulation of neurogenesis; negative regulation of neuron differentiation; nucleus; outward rectifier potassium channel activity; positive regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of transcription, DNA-dependent; transcriptional repressor complex" IPR027775; IPR027757; IPR007087; IPR015880; IPR013087; RE1-silencing transcription factor (Neural-restrictive silencer factor) Rest Nrsf Mus musculus (Mouse) TR23827_c4_g1_i1 O43166 SI1L1_HUMAN 9.00E-65 GO:0005096; GO:0031532; GO:0032861; GO:0030054; GO:0005737; GO:0043197; GO:0048013; GO:0014069; GO:0045211; GO:0050770; GO:0061001; GO:0048167 GTPase activator activity; actin cytoskeleton reorganization; activation of Rap GTPase activity; cell junction; cytoplasm; dendritic spine; ephrin receptor signaling pathway; postsynaptic density; postsynaptic membrane; regulation of axonogenesis; regulation of dendritic spine morphogenesis; regulation of synaptic plasticity IPR021818; IPR001478; IPR000331; Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) SIPA1L1 E6TP1 KIAA0440 Homo sapiens (Human) TR23827_c5_g1_i2 O60292 SI1L3_HUMAN 2.00E-58 GO:0005096; GO:0043547; GO:0051056 GTPase activator activity; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction IPR021818; IPR001478; IPR000331; Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) SIPA1L3 KIAA0545 SPAL3 Homo sapiens (Human) TR23829_c1_g1_i1 P40936 INMT_MOUSE 5.00E-29 GO:0030748; GO:0009308; GO:0005829; GO:0009636; GO:0004790 amine N-methyltransferase activity; amine metabolic process; cytosol; response to toxic substance; thioether S-methyltransferase activity IPR025817; IPR025820; IPR000940; Indolethylamine N-methyltransferase (Indolamine N-methyltransferase) (EC 2.1.1.49) (EC 2.1.1.96) (Aromatic alkylamine N-methyltransferase) (Amine N-methyltransferase) (Arylamine N-methyltransferase) (Thioether S-methyltransferase) (TEMT) Inmt Temt Mus musculus (Mouse) TR23830_c0_g1_i1 Q99LM9 TADA1_MOUSE 1.00E-63 GO:0030914; GO:0043966; GO:0004402; GO:0006355; GO:0003713; GO:0006351 "STAGA complex; histone H3 acetylation; histone acetyltransferase activity; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent" IPR024738; Transcriptional adapter 1 (Transcriptional adapter 1-like protein) Tada1 Tada1l Mus musculus (Mouse) TR23833_c0_g1_i1 P62845 RS15_RAT 2.00E-55 GO:0003723; GO:0022627; GO:0000028; GO:0003735; GO:0006412 RNA binding; cytosolic small ribosomal subunit; ribosomal small subunit assembly; structural constituent of ribosome; translation IPR002222; IPR020934; IPR023575; IPR005713; 40S ribosomal protein S15 (RIG protein) Rps15 Rig Rattus norvegicus (Rat) TR23836_c1_g1_i1 P02597 CALMS_CHICK 3.00E-29 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; "Calmodulin, striated muscle" CCM1 Gallus gallus (Chicken) TR23836_c1_g2_i1 P06787 CALM_YEAST 7.00E-22 GO:0006607; GO:0005509; GO:0048306; GO:0007114; GO:0005935; GO:0005934; GO:0005823; GO:0000131; GO:0000742; GO:0043332; GO:0016237; GO:0006661; GO:0006898; GO:0051300; GO:0042991; GO:0042144 P23287; Q04439; P32380 "NLS-bearing protein import into nucleus; calcium ion binding; calcium-dependent protein binding; cell budding; cellular bud neck; cellular bud tip; central plaque of spindle pole body; incipient cellular bud site; karyogamy involved in conjugation with cellular fusion; mating projection tip; microautophagy; phosphatidylinositol biosynthetic process; receptor-mediated endocytosis; spindle pole body organization; transcription factor import into nucleus; vacuole fusion, non-autophagic" IPR011992; IPR018247; IPR002048; Calmodulin (CaM) CMD1 YBR109C YBR0904 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR23837_c1_g1_i1 Q0IIF9 CP2U1_BOVIN 6.00E-28 GO:0070330; GO:0005789; GO:0020037; GO:0016021; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding IPR001128; IPR017972; IPR002401; IPR008069; Cytochrome P450 2U1 (EC 1.14.14.1) CYP2U1 Bos taurus (Bovine) TR23842_c0_g1_i1 Q9JJY3 NSMA2_MOUSE 2.00E-11 GO:0000137; GO:0000139; GO:0007049; GO:0046872; GO:0007275; GO:0030072; GO:0005886; GO:0007165; GO:0006684; GO:0004767 Golgi cis cisterna; Golgi membrane; cell cycle; metal ion binding; multicellular organismal development; peptide hormone secretion; plasma membrane; signal transduction; sphingomyelin metabolic process; sphingomyelin phosphodiesterase activity IPR005135; Lipid metabolism; sphingolipid metabolism. Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) Smpd3 Mus musculus (Mouse) TR23844_c0_g1_i1 Q6LXD9 RS14Z_METMP 4.00E-10 GO:0019843; GO:0015935; GO:0003735; GO:0006412; GO:0008270 rRNA binding; small ribosomal subunit; structural constituent of ribosome; translation; zinc ion binding IPR001209; IPR018271; IPR023676; 30S ribosomal protein S14 type Z rps14 MMP1413 Methanococcus maripaludis (strain S2 / LL) TR23844_c0_g1_i2 Q4PM47 RS29_IXOSC 6.00E-26 GO:0046872; GO:0005840; GO:0003735; GO:0006412 metal ion binding; ribosome; structural constituent of ribosome; translation IPR001209; IPR018271; 40S ribosomal protein S29 RpS29 Ixodes scapularis (Black-legged tick) (Deer tick) TR23848_c2_g1_i1 Q9CPU4 MGST3_MOUSE 3.00E-17 GO:0005783; GO:0005789; GO:0004602; GO:0004364; GO:0016021; GO:0005635 endoplasmic reticulum; endoplasmic reticulum membrane; glutathione peroxidase activity; glutathione transferase activity; integral to membrane; nuclear envelope IPR023352; IPR001129; Microsomal glutathione S-transferase 3 (Microsomal GST-3) (EC 2.5.1.18) (Microsomal GST-III) Mgst3 Mus musculus (Mouse) TR23858_c0_g1_i1 Q8TC84 FANK1_HUMAN 2.00E-14 GO:0005737; GO:0005634 cytoplasm; nucleus IPR002110; IPR020683; IPR003961; IPR013783; Fibronectin type 3 and ankyrin repeat domains protein 1 FANK1 HSD13 UNQ6504/PRO21382 Homo sapiens (Human) TR23859_c4_g1_i1 Q6IBW4 CNDH2_HUMAN 4.00E-12 GO:0005694; GO:0030261; GO:0005634 P42695; Q86XI2; O95347 chromosome; chromosome condensation; nucleus IPR009378; Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) NCAPH2 CAPH2 Homo sapiens (Human) TR23859_c5_g1_i1 Q3SZL8 CNDH2_BOVIN 2.00E-08 GO:0030261; GO:0005634 chromosome condensation; nucleus IPR009378; Condensin-2 complex subunit H2 (Non-SMC condensin II complex subunit H2) NCAPH2 Bos taurus (Bovine) TR2386_c0_g1_i1 Q6AYF9 IIGP5_RAT 6.00E-13 GO:0005525; GO:0016817; GO:0016020 "GTP binding; hydrolase activity, acting on acid anhydrides; membrane" IPR007743; IPR027417; Interferon-inducible GTPase 5 (EC 3.6.5.-) (Immunity-related GTPase cinema 1) Irgc Iigp5 Irgc1 Rattus norvegicus (Rat) TR23860_c0_g1_i1 Q54468 CHB_SERMA 4.00E-69 GO:0004563; GO:0006032; GO:0042597; GO:0030247; GO:0000272 beta-N-acetylhexosaminidase activity; chitin catabolic process; periplasmic space; polysaccharide binding; polysaccharide catabolic process IPR025705; IPR008965; IPR012291; IPR004866; IPR004867; IPR013812; IPR015883; IPR015882; IPR013781; IPR017853; IPR014756; Glycan degradation; chitin degradation. Chitobiase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (N-acetyl-beta-glucosaminidase) chb Serratia marcescens TR23861_c0_g1_i1 Q5RL73 RBM48_HUMAN 5.00E-23 GO:0003723; GO:0005634 RNA binding; nucleus RNA-binding protein 48 RBM48 C7orf64 HSPC304 Homo sapiens (Human) TR23862_c0_g1_i1 P79098 AMPN_BOVIN 2.00E-55 GO:0004177; GO:0001525; GO:0030154; GO:0016021; GO:0008237; GO:0006508; GO:0009615; GO:0001618; GO:0008270 aminopeptidase activity; angiogenesis; cell differentiation; integral to membrane; metallopeptidase activity; proteolysis; response to virus; virus receptor activity; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (AP-N) (bAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) ANPEP APN Bos taurus (Bovine) TR23862_c0_g2_i1 P79098 AMPN_BOVIN 1.00E-55 GO:0004177; GO:0001525; GO:0030154; GO:0016021; GO:0008237; GO:0006508; GO:0009615; GO:0001618; GO:0008270 aminopeptidase activity; angiogenesis; cell differentiation; integral to membrane; metallopeptidase activity; proteolysis; response to virus; virus receptor activity; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (AP-N) (bAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) ANPEP APN Bos taurus (Bovine) TR23862_c1_g1_i2 P91887 AMPN_PLUXY 7.00E-23 GO:0004177; GO:0031225; GO:0008237; GO:0005886; GO:0006508; GO:0008270 aminopeptidase activity; anchored to membrane; metallopeptidase activity; plasma membrane; proteolysis; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (AP-N) (EC 3.4.11.2) (Apn1) (Microsomal aminopeptidase) APN1 Plutella xylostella (Diamondback moth) (Plutella maculipennis) TR23864_c1_g1_i1 Q6PB06 AGPD1_XENLA 4.00E-56 GO:0005737; GO:0047992 cytoplasm; hydroxylysine kinase activity IPR002575; IPR011009; Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC 2.7.1.81) hykk agphd1 Xenopus laevis (African clawed frog) TR23869_c0_g1_i1 Q96EU6 RRP36_HUMAN 7.00E-34 GO:0005730; GO:0006364; GO:0042274 nucleolus; rRNA processing; ribosomal small subunit biogenesis IPR009292; Ribosomal RNA processing protein 36 homolog RRP36 C6orf153 HSPC253 Homo sapiens (Human) TR23875_c0_g1_i1 P51544 KARG_HALMK 0 GO:0005524; GO:0004054 ATP binding; arginine kinase activity IPR022415; IPR022414; IPR022413; IPR014746; Arginine kinase (AK) (EC 2.7.3.3) Haliotis madaka (Giant abalone) (Nordotis madaka) TR23880_c0_g2_i1 Q9BXX0 EMIL2_HUMAN 2.00E-09 GO:0007155; GO:0005581; GO:0030023; GO:0005576 cell adhesion; collagen; extracellular matrix constituent conferring elasticity; extracellular region IPR001073; IPR011489; IPR008983; EMILIN-2 (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10) EMILIN2 Homo sapiens (Human) TR23880_c3_g1_i1 Q09575 YRD6_CAEEL 2.00E-08 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR23884_c1_g1_i1 Q53HV7 SMUG1_HUMAN 4.00E-17 GO:0003677; GO:0045008; GO:0005730; GO:0005654; GO:0017065 Q93062 DNA binding; depyrimidination; nucleolus; nucleoplasm; single-strand selective uracil DNA N-glycosylase activity IPR005122; Single-strand selective monofunctional uracil DNA glycosylase (EC 3.2.2.-) SMUG1 Homo sapiens (Human) TR23885_c0_g1_i1 Q9D504 ANKR7_MOUSE 8.00E-15 GO:0005634 nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 7 Ankrd7 Mus musculus (Mouse) TR23885_c0_g1_i2 Q337A0 XB33_ORYSJ 4.00E-09 GO:0016874; GO:0016567; GO:0008270 ligase activity; protein ubiquitination; zinc ion binding IPR002110; IPR020683; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase XBOS33 (EC 6.3.2.-) (Ankyrin repeat domain and RING finger-containing protein XBOS33) (XB3 protein homolog 3) XBOS33 Os10g0521600 LOC_Os10g37730 OSJNBb0018B10.26 OSJNBb0028C01.29 Oryza sativa subsp. japonica (Rice) TR23885_c0_g2_i1 Q5ZIJ9 MIB2_CHICK 2.00E-13 GO:0007219; GO:0005737; GO:0004842; GO:0008270 Notch signaling pathway; cytoplasm; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) TR23885_c0_g3_i1 Q1RJR4 Y319_RICBR 3.00E-06 IPR002110; IPR020683; Putative ankyrin repeat protein RBE_0319 RBE_0319 Rickettsia bellii (strain RML369-C) TR23886_c0_g1_i1 P48733 UROM_BOVIN 4.00E-14 GO:0031225; GO:0016324; GO:0016323; GO:0005509; GO:0060170; GO:0005576; GO:0072372; GO:0000922 anchored to membrane; apical plasma membrane; basolateral plasma membrane; calcium ion binding; cilium membrane; extracellular region; primary cilium; spindle pole IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR023413; IPR009030; IPR001507; IPR017977; "Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]" UMOD Bos taurus (Bovine) TR23891_c0_g1_i1 Q9Z2G0 FEM1B_MOUSE 1.00E-66 GO:0006915; GO:0060442; GO:0005737; GO:0060743; GO:0005634; GO:0016567; GO:2000001; GO:1902041; GO:0051438; GO:0004842 apoptotic process; branching involved in prostate gland morphogenesis; cytoplasm; epithelial cell maturation involved in prostate gland development; nucleus; protein ubiquitination; regulation of DNA damage checkpoint; regulation of extrinsic apoptotic signaling pathway via death domain receptors; regulation of ubiquitin-protein ligase activity; ubiquitin-protein ligase activity IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha) (mt-Fem) Fem1b F1aa Kiaa0396 Mus musculus (Mouse) TR23893_c2_g1_i1 Q8BJM3 R3HCL_MOUSE 7.00E-40 GO:0000166 nucleotide binding IPR012677 R3H and coiled-coil domain-containing protein 1-like (Growth inhibition and differentiation-related protein 88 homolog) R3hcc1l D19Ertd386e Gidrp88 Mus musculus (Mouse) TR23901_c0_g1_i1 Q9NPG1 FZD3_HUMAN 2.00E-07 GO:0004930; GO:0007199; GO:0042813; GO:0045177; GO:0016324; GO:0030424; GO:0060070; GO:0033278; GO:0071679; GO:0005737; GO:0030425; GO:0001736; GO:0021754; GO:0008406; GO:0001942; GO:0042472; GO:0016021; GO:0016328; GO:0001843; GO:0001764; GO:0032589; GO:0043025; GO:0036342; GO:0048786; GO:0001944 G-protein coupled receptor activity; G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; Wnt-activated receptor activity; apical part of cell; apical plasma membrane; axon; canonical Wnt receptor signaling pathway; cell proliferation in midbrain; commissural neuron axon guidance; cytoplasm; dendrite; establishment of planar polarity; facial nucleus development; gonad development; hair follicle development; inner ear morphogenesis; integral to membrane; lateral plasma membrane; neural tube closure; neuron migration; neuron projection membrane; neuronal cell body; post-anal tail morphogenesis; presynaptic active zone; vasculature development IPR000539; IPR015526; IPR020067; IPR026553; IPR017981; Frizzled-3 (Fz-3) (hFz3) FZD3 Homo sapiens (Human) TR23906_c2_g1_i1 P68827 NAGPA_BOVIN 1.00E-68 GO:0032580; GO:0003944; GO:0016021; GO:0006486 Golgi cisterna membrane; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity; integral to membrane; protein glycosylation IPR018711; IPR000742; IPR013032; Protein modification; protein glycosylation. N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) (Mannose 6-phosphate-uncovering enzyme) (Phosphodiester alpha-GlcNAcase) NAGPA Bos taurus (Bovine) TR23906_c3_g1_i1 P22105 TENX_HUMAN 1.00E-14 GO:0030036; GO:0007155; GO:0016337; GO:0007160; GO:0030199; GO:0032963; GO:0048251; GO:0043206; GO:0005615; GO:0006631; GO:0008201; GO:0005178; GO:0005622; GO:0005578; GO:0043506; GO:0006641 actin cytoskeleton organization; cell adhesion; cell-cell adhesion; cell-matrix adhesion; collagen fibril organization; collagen metabolic process; elastic fiber assembly; extracellular fibril organization; extracellular space; fatty acid metabolic process; heparin binding; integrin binding; intracellular; proteinaceous extracellular matrix; regulation of JUN kinase activity; triglyceride metabolic process IPR000742; IPR013032; IPR014716; IPR014715; IPR002181; IPR020837; IPR003961; IPR013783; Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) TR23908_c0_g1_i1 Q17QM8 DUS14_BOVIN 9.00E-46 GO:0017017; GO:0035335; GO:0004725; GO:0008138 MAP kinase tyrosine/serine/threonine phosphatase activity; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR020417; IPR020420; IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Dual specificity protein phosphatase 14 (EC 3.1.3.16) (EC 3.1.3.48) DUSP14 Bos taurus (Bovine) TR23913_c0_g1_i1 P0C5E3 PALLD_RAT 8.00E-06 GO:0030018; GO:0044295; GO:0030054; GO:0071456; GO:0030175; GO:0031175; GO:0043025; GO:0002102; GO:0071803; GO:0001726; GO:0031529; GO:0001725; GO:0060707; GO:0042060 Z disc; axonal growth cone; cell junction; cellular response to hypoxia; filopodium; neuron projection development; neuronal cell body; podosome; positive regulation of podosome assembly; ruffle; ruffle organization; stress fiber; trophoblast giant cell differentiation; wound healing IPR007110; IPR013783; IPR013098; IPR003598; Palladin (Fragment) Palld Rattus norvegicus (Rat) TR23913_c0_g2_i1 O14511 NRG2_HUMAN 1.00E-07 GO:0038095; GO:0009790; GO:0007173; GO:0005576; GO:0008543; GO:0045087; GO:0016021; GO:0048011; GO:0048015; GO:0005886; GO:0005102 Fc-epsilon receptor signaling pathway; embryo development; epidermal growth factor receptor signaling pathway; extracellular region; fibroblast growth factor receptor signaling pathway; innate immune response; integral to membrane; neurotrophin TRK receptor signaling pathway; phosphatidylinositol-mediated signaling; plasma membrane; receptor binding IPR000742; IPR013032; IPR007110; IPR013783; IPR013098; IPR003598; IPR002154; "Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2) [Cleaved into: Neuregulin-2 (NRG-2) (Divergent of neuregulin-1) (DON-1) (Neural- and thymus-derived activator for ERBB kinases) (NTAK)]" NRG2 NTAK Homo sapiens (Human) TR23913_c2_g1_i1 Q9VS29 DSCL_DROME 5.00E-25 GO:0007156; GO:0005887; GO:0048812 homophilic cell adhesion; integral to plasma membrane; neuron projection morphogenesis IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Down syndrome cell adhesion molecule-like protein Dscam2 Dscam2 CG42256 Drosophila melanogaster (Fruit fly) TR23913_c3_g1_i1 P97527 CNTN5_RAT 3.00E-08 GO:0031225; GO:0007155; GO:0005737; GO:0005886; GO:0007605 anchored to membrane; cell adhesion; cytoplasm; plasma membrane; sensory perception of sound IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Contactin-5 (Neural recognition molecule NB-2) Cntn5 Rattus norvegicus (Rat) TR23913_c3_g2_i1 Q69Z26 CNTN4_MOUSE 1.00E-14 GO:0031225; GO:0007420; GO:0007155; GO:0005576; GO:0045665; GO:0031175; GO:0005886 anchored to membrane; brain development; cell adhesion; extracellular region; negative regulation of neuron differentiation; neuron projection development; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Contactin-4 (Brain-derived immunoglobulin superfamily protein 2) (BIG-2) Cntn4 Kiaa3024 Mus musculus (Mouse) TR23913_c4_g1_i1 Q9VS29 DSCL_DROME 1.00E-67 GO:0007156; GO:0005887; GO:0048812 homophilic cell adhesion; integral to plasma membrane; neuron projection morphogenesis IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Down syndrome cell adhesion molecule-like protein Dscam2 Dscam2 CG42256 Drosophila melanogaster (Fruit fly) TR23915_c0_g1_i1 Q3KPV7 PI15_XENLA 1.00E-17 GO:0005576; GO:0030414 extracellular region; peptidase inhibitor activity IPR001283; IPR018244; IPR014044; Peptidase inhibitor 15 pi15 Xenopus laevis (African clawed frog) TR2392_c0_g1_i1 B1AVY7 KI16B_MOUSE 2.00E-11 GO:0005524; GO:0006895; GO:0005769; GO:0031901; GO:0045022; GO:0007492; GO:0007173; GO:0008543; GO:0001704; GO:0005871; GO:0005874; GO:0007018; GO:0005547; GO:0043325; GO:0080025; GO:0032266; GO:0008574; GO:0032801; GO:0001919 "ATP binding; Golgi to endosome transport; early endosome; early endosome membrane; early endosome to late endosome transport; endoderm development; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; formation of primary germ layer; kinesin complex; microtubule; microtubule-based movement; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding; plus-end-directed microtubule motor activity; receptor catabolic process; regulation of receptor recycling" IPR000253; IPR027640; IPR019821; IPR001752; IPR027417; IPR001683; IPR008984; Kinesin-like protein KIF16B Kif16b Kiaa1590 Mus musculus (Mouse) TR23921_c2_g1_i3 Q7TPV2 DZIP3_MOUSE 4.00E-08 GO:0003723; GO:0005737; GO:0016874; GO:0019902; GO:0016567; GO:0008270 RNA binding; cytoplasm; ligase activity; phosphatase binding; protein ubiquitination; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog) Dzip3 Kiaa0675 Mus musculus (Mouse) TR23926_c0_g2_i1 Q2TBK2 RM09_BOVIN 1.00E-19 GO:0005739; GO:0005840; GO:0003735; GO:0006412 mitochondrion; ribosome; structural constituent of ribosome; translation IPR000244; IPR009027; IPR020070; "39S ribosomal protein L9, mitochondrial (L9mt) (MRP-L9)" MRPL9 Bos taurus (Bovine) TR23940_c2_g1_i2 Q28756 OXYR_SHEEP 4.00E-08 GO:0016021; GO:0004990; GO:0005886; GO:0005000 integral to membrane; oxytocin receptor activity; plasma membrane; vasopressin receptor activity IPR000276; IPR017452; IPR002062; IPR001817; Oxytocin receptor (OT-R) OXTR Ovis aries (Sheep) TR23944_c0_g1_i1 Q9UMZ3 PTPRQ_HUMAN 2.00E-08 GO:0042472; GO:0016021; GO:0035335; GO:0004725; GO:0045598 inner ear morphogenesis; integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; regulation of fat cell differentiation IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) PTPRQ Homo sapiens (Human) TR23944_c0_g2_i1 Q2EY14 PRTGA_DANRE 2.00E-12 GO:0016021; GO:0007275 integral to membrane; multicellular organismal development IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; Protogenin A prtga Danio rerio (Zebrafish) (Brachydanio rerio) TR23944_c2_g1_i1 Q2EY15 PRTG_MOUSE 3.00E-12 GO:0016021; GO:0007275 integral to membrane; multicellular organismal development IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; Protogenin (Protein Shen-Dan) Prtg Mus musculus (Mouse) TR23944_c3_g1_i1 Q8IVU1 IGDC3_HUMAN 2.00E-08 GO:0005887; GO:0050885 integral to plasma membrane; neuromuscular process controlling balance IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; Immunoglobulin superfamily DCC subclass member 3 (Putative neuronal cell adhesion molecule) IGDCC3 PUNC Homo sapiens (Human) TR23946_c0_g1_i2 Q0P5A1 DCTN3_BOVIN 7.00E-32 GO:0005813; GO:0032154; GO:0000777; GO:0000910; GO:0005869; GO:0007017; GO:0030496; GO:0007067; GO:0048471; GO:0005819 centrosome; cleavage furrow; condensed chromosome kinetochore; cytokinesis; dynactin complex; microtubule-based process; midbody; mitosis; perinuclear region of cytoplasm; spindle IPR009991; Dynactin subunit 3 DCTN3 Bos taurus (Bovine) TR23947_c1_g1_i2 P0C024 NUDT7_HUMAN 2.00E-31 GO:0046356; GO:0003986; GO:0050873; GO:0015938; GO:0016818; GO:0000287; GO:0030145; GO:0009132; GO:0005777; GO:0030515 "acetyl-CoA catabolic process; acetyl-CoA hydrolase activity; brown fat cell differentiation; coenzyme A catabolic process; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; magnesium ion binding; manganese ion binding; nucleoside diphosphate metabolic process; peroxisome; snoRNA binding" IPR000086; IPR015797; IPR000059; Peroxisomal coenzyme A diphosphatase NUDT7 (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 7) (Nudix motif 7) NUDT7 Homo sapiens (Human) TR23953_c3_g2_i1 P34410 TWK7_CAEEL 4.00E-29 GO:0016021; GO:0005267 integral to membrane; potassium channel activity IPR003280; IPR013099; IPR003092; TWiK family of potassium channels protein 7 twk-7 twk-8 F22B7.7 Caenorhabditis elegans TR23954_c0_g1_i1 Q4UMH6 Y381_RICFE 6.00E-13 GO:0015969 guanosine tetraphosphate metabolic process IPR002110; IPR020683; IPR007685; Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR23956_c2_g1_i1 Q7KRW1 TRC8_DROME 5.00E-11 GO:0005783; GO:0005789; GO:0016021; GO:0045926; GO:0007418; GO:0008270 Q9XZ58; Q9V3C1 endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; negative regulation of growth; ventral midline development; zinc ion binding IPR025754; IPR001841; IPR013083; Protein TRC8 homolog Trc8 CG2304 Drosophila melanogaster (Fruit fly) TR23957_c0_g1_i1 A2VDD2 TC1DB_XENLA 1.00E-22 IPR005334; Tctex1 domain-containing protein 1-B (Fragment) tctex1d1-b Xenopus laevis (African clawed frog) TR23964_c0_g1_i1 B6LS00 U728_BRAFL 1.00E-32 IPR027885; UPF0728 protein BRAFLDRAFT_270831 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR23969_c0_g1_i1 O48709 PI5K3_ARATH 5.00E-15 GO:0016308; GO:0005524; GO:0016324; GO:0005737; GO:0048768 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding; apical plasma membrane; cytoplasm; root hair cell tip growth IPR003409; IPR017163; IPR023610; IPR027483; IPR002498; IPR027484; IPR016034; Phosphatidylinositol 4-phosphate 5-kinase 3 (AtPIP5K3) (EC 2.7.1.68) (1-phosphatidylinositol 4-phosphate kinase 3) (Diphosphoinositide kinase 3) (PtdIns(4)P-5-kinase 3) PIP5K3 At2g26420 T9J22.9 Arabidopsis thaliana (Mouse-ear cress) TR23969_c0_g1_i2 Q8WYR4 RSPH1_HUMAN 1.00E-69 GO:0005829; GO:0007126; GO:0005634 cytosol; meiosis; nucleus IPR003409; Radial spoke head 1 homolog (Cancer/testis antigen 79) (CT79) (Male meiotic metaphase chromosome-associated acidic protein) (Meichroacidin) (Testis-specific gene A2 protein) RSPH1 TSA2 TSGA2 Homo sapiens (Human) TR23971_c0_g1_i1 Q1LWV4 LHX9_DANRE 4.00E-81 GO:0008045; GO:0045892; GO:0005634; GO:0043565; GO:0003700; GO:0021794; GO:0003714; GO:0008270 "motor neuron axon guidance; negative regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; thalamus development; transcription corepressor activity; zinc ion binding" IPR017970; IPR001356; IPR009057; IPR001781; LIM/homeobox protein Lhx9 (LIM homeobox protein 9) lhx9 Danio rerio (Zebrafish) (Brachydanio rerio) TR23973_c6_g1_i1 Q86WJ1 CHD1L_HUMAN 9.00E-35 GO:0005524; GO:0004003; GO:0003677; GO:0006281; GO:0006338; GO:0005737; GO:0000166; GO:0005634; GO:0005886 ATP binding; ATP-dependent DNA helicase activity; DNA binding; DNA repair; chromatin remodeling; cytoplasm; nucleotide binding; nucleus; plasma membrane IPR002464; IPR014001; IPR001650; IPR002589; IPR027417; IPR000330; Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.12) (Amplified in liver cancer protein 1) CHD1L ALC1 Homo sapiens (Human) TR23974_c0_g1_i1 P86948 MP_PINMA 1.00E-16 GO:0005576 extracellular region Mantle protein (MP) Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) TR23978_c1_g1_i1 P14282 CO8A1_RABIT 3.00E-06 GO:0001525; GO:0005604; GO:0007155; GO:0005581 angiogenesis; basement membrane; cell adhesion; collagen IPR001073; IPR008160; IPR008983; Collagen alpha-1(VIII) chain (Endothelial collagen) [Cleaved into: Vastatin] COL8A1 Oryctolagus cuniculus (Rabbit) TR23980_c0_g1_i1 Q64625 GPX6_RAT 7.00E-38 GO:0005576; GO:0004602; GO:0006979 extracellular region; glutathione peroxidase activity; response to oxidative stress IPR000889; IPR012336; Glutathione peroxidase 6 (GPx-6) (GSHPx-6) (EC 1.11.1.9) (Odorant-metabolizing protein RY2D1) Gpx6 Rattus norvegicus (Rat) TR23993_c0_g1_i1 Q80TR4 SLIT1_MOUSE 2.00E-13 GO:0048846; GO:0005509; GO:0005737; GO:0033563; GO:0040023; GO:0005615; GO:0008045; GO:0050919; GO:0051964; GO:0005102; GO:0031290; GO:0022028 axon extension involved in axon guidance; calcium ion binding; cytoplasm; dorsal/ventral axon guidance; establishment of nucleus localization; extracellular space; motor neuron axon guidance; negative chemotaxis; negative regulation of synapse assembly; receptor binding; retinal ganglion cell axon guidance; tangential migration from the subventricular zone to the olfactory bulb IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 1 protein (Slit-1) Slit1 Kiaa0813 Mus musculus (Mouse) TR23994_c1_g1_i1 Q14643 ITPR1_HUMAN 3.00E-89 GO:0038095; GO:0038096; GO:0007202; GO:0005955; GO:0032469; GO:0005789; GO:0006112; GO:0007173; GO:0008543; GO:0045087; GO:0005220; GO:0016021; GO:0005218; GO:0070059; GO:0048011; GO:0005637; GO:0005730; GO:0035091; GO:0030168; GO:0031088; GO:0031095; GO:0009791; GO:0014069; GO:0050796; GO:0051209; GO:0001666; GO:0016529; GO:0044281; GO:0050882 "Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; activation of phospholipase C activity; calcineurin complex; endoplasmic reticulum calcium ion homeostasis; endoplasmic reticulum membrane; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; integral to membrane; intracellular ligand-gated calcium channel activity; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; neurotrophin TRK receptor signaling pathway; nuclear inner membrane; nucleolus; phosphatidylinositol binding; platelet activation; platelet dense granule membrane; platelet dense tubular network membrane; post-embryonic development; postsynaptic density; regulation of insulin secretion; release of sequestered calcium ion into cytosol; response to hypoxia; sarcoplasmic reticulum; small molecule metabolic process; voluntary musculoskeletal movement" IPR016024; IPR000699; IPR014821; IPR000493; IPR005821; IPR016093; IPR013662; IPR015925; "Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)" ITPR1 INSP3R1 Homo sapiens (Human) TR23996_c2_g1_i1 Q15582 BGH3_HUMAN 4.00E-15 GO:0001525; GO:0007155; GO:0008283; GO:0050840; GO:0030198; GO:0005615; GO:0070062; GO:0005178; GO:0007162; GO:0005886; GO:0005578; GO:0050896; GO:0007601 angiogenesis; cell adhesion; cell proliferation; extracellular matrix binding; extracellular matrix organization; extracellular space; extracellular vesicular exosome; integrin binding; negative regulation of cell adhesion; plasma membrane; proteinaceous extracellular matrix; response to stimulus; visual perception IPR011489; IPR000782; IPR016666; Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) (Kerato-epithelin) (RGD-containing collagen-associated protein) (RGD-CAP) TGFBI BIGH3 Homo sapiens (Human) TR24002_c1_g1_i1 P55009 AIF1_RAT 6.00E-45 GO:0016601; GO:0051015; GO:0051017; GO:0030041; GO:0005509; GO:0031668; GO:0032870; GO:0071346; GO:0005856; GO:0005829; GO:0006954; GO:0030027; GO:0042116; GO:0043066; GO:0010629; GO:0005634; GO:0043204; GO:0001891; GO:0006911; GO:1900087; GO:2000406; GO:0042102; GO:0090026; GO:0014739; GO:0045429; GO:0001934; GO:0071673; GO:0048661; GO:0048678; GO:0051602; GO:0097178; GO:0032587 "Rac protein signal transduction; actin filament binding; actin filament bundle assembly; actin filament polymerization; calcium ion binding; cellular response to extracellular stimulus; cellular response to hormone stimulus; cellular response to interferon-gamma; cytoskeleton; cytosol; inflammatory response; lamellipodium; macrophage activation; negative regulation of apoptotic process; negative regulation of gene expression; nucleus; perikaryon; phagocytic cup; phagocytosis, engulfment; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of T cell migration; positive regulation of T cell proliferation; positive regulation of monocyte chemotaxis; positive regulation of muscle hyperplasia; positive regulation of nitric oxide biosynthetic process; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell chemotaxis; positive regulation of smooth muscle cell proliferation; response to axon injury; response to electrical stimulus; ruffle assembly; ruffle membrane" IPR011992; IPR002048; Allograft inflammatory factor 1 (AIF-1) (Ionized calcium-binding adapter molecule 1) (MRF-1) (Microglia response factor) Aif1 Iba1 Mrf1 Rattus norvegicus (Rat) TR24006_c0_g1_i1 Q8WXC6 MYOV2_HUMAN 1.00E-15 Myeloma-overexpressed gene 2 protein MYEOV2 Homo sapiens (Human) TR24013_c0_g1_i1 Q9D0B6 CX026_MOUSE 2.00E-42 IPR021148; IPR008476; IPR023139; Protein PBDC1 (Polysaccharide biosynthesis domain-containing protein 1) Pbdc1 Mus musculus (Mouse) TR24017_c4_g1_i1 Q00PJ1 CTTB2_ATEAB 2.00E-33 GO:0005938; GO:0043197 cell cortex; dendritic spine IPR002110; IPR020683; IPR019131; Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog) TR24023_c0_g1_i1 P24081 AN_NPVOP 4.00E-07 GO:0003677; GO:0004519; GO:0004527; GO:0042025; GO:0090305 DNA binding; endonuclease activity; exonuclease activity; host cell nucleus; nucleic acid phosphodiester bond hydrolysis IPR011604; IPR001616; IPR011335; Alkaline nuclease (AN) (EC 3.1.-.-) ALK-EXO ORF131 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) TR24026_c0_g2_i1 P35408 PE2R4_HUMAN 1.00E-52 GO:0070371; GO:0007254; GO:0042093; GO:0007188; GO:0060348; GO:0071260; GO:0016021; GO:0050710; GO:2000420; GO:0050728; GO:0033624; GO:0005886; GO:0050715; GO:0050729; GO:0004957; GO:0030278; GO:0051492; GO:0032496 ERK1 and ERK2 cascade; JNK cascade; T-helper cell differentiation; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; bone development; cellular response to mechanical stimulus; integral to membrane; negative regulation of cytokine secretion; negative regulation of eosinophil extravasation; negative regulation of inflammatory response; negative regulation of integrin activation; plasma membrane; positive regulation of cytokine secretion; positive regulation of inflammatory response; prostaglandin E receptor activity; regulation of ossification; regulation of stress fiber assembly; response to lipopolysaccharide IPR000276; IPR017452; IPR001758; IPR008365; IPR001244; Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 PTGER2 Homo sapiens (Human) TR24029_c0_g1_i1 Q28BZ2 HINT3_XENTR 8.00E-42 GO:0005737; GO:0016787; GO:0008152; GO:0000166; GO:0005634 cytoplasm; hydrolase activity; metabolic process; nucleotide binding; nucleus IPR001310; IPR011146; Histidine triad nucleotide-binding protein 3 (HINT-3) (EC 3.-.-.-) hint3 TEgg107p05.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR24030_c2_g1_i1 Q7TN88 PK1L2_MOUSE 4.00E-55 GO:0005262; GO:0005509; GO:0030246; GO:0050982; GO:0016021; GO:0016020; GO:0007218 calcium channel activity; calcium ion binding; carbohydrate binding; detection of mechanical stimulus; integral to membrane; membrane; neuropeptide signaling pathway IPR001304; IPR016186; IPR016187; IPR000203; IPR000922; IPR008976; IPR022409; IPR002859; IPR013122; IPR003915; IPR000601; IPR001024; IPR014010; Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) Pkd1l2 Mus musculus (Mouse) TR24031_c0_g1_i1 Q9W534 MOODY_DROME 5.00E-37 GO:0004930; GO:0008366; GO:0048148; GO:0048149; GO:0035095; GO:0030866; GO:0060857; GO:0016021; GO:0005886; GO:0005919; GO:0019991; GO:0007419 G-protein coupled receptor activity; axon ensheathment; behavioral response to cocaine; behavioral response to ethanol; behavioral response to nicotine; cortical actin cytoskeleton organization; establishment of glial blood-brain barrier; integral to membrane; plasma membrane; pleated septate junction; septate junction assembly; ventral cord development IPR000276; IPR017452; G-protein coupled receptor moody moody CG4322 Drosophila melanogaster (Fruit fly) TR24037_c0_g1_i3 Q7TPV2 DZIP3_MOUSE 3.00E-06 GO:0003723; GO:0005737; GO:0016874; GO:0019902; GO:0016567; GO:0008270 RNA binding; cytoplasm; ligase activity; phosphatase binding; protein ubiquitination; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog) Dzip3 Kiaa0675 Mus musculus (Mouse) TR24039_c0_g1_i1 P74897 YQA3_THEAQ 2.00E-08 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein in QAH/OAS sulfhydrylase 3'region (USP) Thermus aquaticus TR24039_c0_g1_i2 Q49YE0 Y1056_STAS1 4.00E-08 GO:0005737; GO:0006950 cytoplasm; response to stress IPR014729; IPR006015; IPR006016; Putative universal stress protein SSP1056 SSP1056 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) TR24040_c1_g1_i1 Q96MW7 TIGD1_HUMAN 2.00E-09 GO:0003677; GO:0005634 DNA binding; nucleus IPR004875; IPR009057; IPR006600; IPR007889; Tigger transposable element-derived protein 1 TIGD1 Homo sapiens (Human) TR24040_c5_g1_i2 Q8BUZ3 TIGD4_MOUSE 4.00E-06 GO:0003677; GO:0005634 DNA binding; nucleus IPR004875; IPR009057; IPR006600; IPR007889; Tigger transposable element-derived protein 4 Tigd4 Mus musculus (Mouse) TR24042_c0_g1_i2 Q8QGW7 LITAF_CHICK 2.00E-15 GO:0005125; GO:0005737; GO:0006355; GO:0006351 "cytokine activity; cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) TR24046_c0_g1_i2 A6QQV6 ANM7_BOVIN 0 GO:0043046; GO:0016277; GO:0030154; GO:0005829; GO:0044020; GO:0005634; GO:0035243; GO:0006349; GO:0006355; GO:0000387; GO:0006351 "DNA methylation involved in gamete generation; [myelin basic protein]-arginine N-methyltransferase activity; cell differentiation; cytosol; histone methyltransferase activity (H4-R3 specific); nucleus; protein-arginine omega-N symmetric methyltransferase activity; regulation of gene expression by genetic imprinting; regulation of transcription, DNA-dependent; spliceosomal snRNP assembly; transcription, DNA-dependent" IPR025799; IPR025801; IPR014644; IPR010456; Protein arginine N-methyltransferase 7 (EC 2.1.1.-) (Histone-arginine N-methyltransferase PRMT7) (EC 2.1.1.125) ([Myelin basic protein]-arginine N-methyltransferase PRMT7) (EC 2.1.1.126) PRMT7 Bos taurus (Bovine) TR24049_c2_g1_i1 Q708S4 ASI4A_DANRE 1.00E-19 GO:0005887; GO:0015280 integral to plasma membrane; ligand-gated sodium channel activity IPR001873; IPR020903; Acid-sensing ion channel 4 (ASIC4) (Acid-sensing ion channel 4.1) (Amiloride-sensitive cation channel 4-A) (ZASIC4.1) asic4 accn4a Danio rerio (Zebrafish) (Brachydanio rerio) TR24051_c3_g4_i1 A4QN56 NAGT1_DANRE 3.00E-34 GO:0016324; GO:0008643; GO:0016021; GO:0006814; GO:0015293 apical plasma membrane; carbohydrate transport; integral to membrane; sodium ion transport; symporter activity IPR011701; IPR016196; Sodium-dependent glucose transporter 1 naglt1 zgc:162161 Danio rerio (Zebrafish) (Brachydanio rerio) TR24052_c1_g2_i1 Q9WVH6 ANGP4_MOUSE 1.00E-15 GO:0048014; GO:0001525; GO:0071456; GO:0007492; GO:0005615; GO:0016525; GO:0043066; GO:0043537; GO:0045766; GO:0043536; GO:0030297; GO:0005172 Tie signaling pathway; angiogenesis; cellular response to hypoxia; endoderm development; extracellular space; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of blood vessel endothelial cell migration; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; transmembrane receptor protein tyrosine kinase activator activity; vascular endothelial growth factor receptor binding IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3) Angpt4 Agpt4 Ang3 Mus musculus (Mouse) TR24052_c1_g2_i2 Q24K15 ANGP4_BOVIN 2.00E-15 GO:0001525; GO:0005576 angiogenesis; extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) TR24052_c1_g3_i1 Q3SZZ7 FGL1_BOVIN 2.00E-40 GO:0005576 extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein 1 FGL1 Bos taurus (Bovine) TR24053_c4_g2_i1 Q09575 YRD6_CAEEL 2.00E-16 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR24053_c5_g1_i1 P10394 POL4_DROME 3.00E-13 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR24056_c3_g1_i1 A2A891 CMTA1_MOUSE 4.00E-25 GO:0003677; GO:0005737; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cytoplasm; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002110; IPR020683; IPR005559; IPR013783; IPR014756; IPR002909; IPR000048; Calmodulin-binding transcription activator 1 Camta1 Kiaa0833 Mus musculus (Mouse) TR24056_c6_g1_i1 Q9Y6Y1 CMTA1_HUMAN 1.00E-22 GO:0003677; GO:0005737; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cytoplasm; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002110; IPR020683; IPR005559; IPR013783; IPR014756; IPR002909; IPR000048; IPR027417; Calmodulin-binding transcription activator 1 CAMTA1 KIAA0833 MSTP023 Homo sapiens (Human) TR24059_c3_g1_i1 O02414 DYL1_ANTCR 8.00E-58 GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0007017; GO:0003774 cilium; cytoplasm; dynein complex; microtubule; microtubule-based process; motor activity IPR019763; IPR001372; "Dynein light chain LC6, flagellar outer arm" Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR24059_c3_g1_i2 Q78P75 DYL2_RAT 9.00E-58 GO:0005813; GO:0005737; GO:0008092; GO:0030286; GO:0005874; GO:0007017; GO:0003774; GO:0016459; GO:0008039; GO:0006810 centrosome; cytoplasm; cytoskeletal protein binding; dynein complex; microtubule; microtubule-based process; motor activity; myosin complex; synaptic target recognition; transport IPR019763; IPR001372; "Dynein light chain 2, cytoplasmic (Dynein light chain LC8-type 2)" Dynll2 Dlc2 Rattus norvegicus (Rat) TR24061_c0_g2_i1 Q6ZMW2 ZN782_HUMAN 5.00E-60 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 782 ZNF782 Homo sapiens (Human) TR24064_c1_g1_i1 Q29NC4 CBPA1_DROPS 1.00E-41 GO:0005615; GO:0004181; GO:0006508; GO:0008270 extracellular space; metallocarboxypeptidase activity; proteolysis; zinc ion binding IPR000834; IPR003146; IPR009020; Zinc carboxypeptidase A 1 (EC 3.4.17.-) GA14587 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR24072_c0_g3_i1 P86854 PLCL_MYTGA 6.00E-15 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR24074_c0_g1_i2 P82927 RM42_BOVIN 2.00E-16 GO:0005763; GO:0005886 mitochondrial small ribosomal subunit; plasma membrane IPR019346; "39S ribosomal protein L42, mitochondrial (L42mt) (MRP-L42) (28S ribosomal protein S32, mitochondrial) (MRP-S32) (S32mt)" MRPL42 MRPS32 Bos taurus (Bovine) TR24082_c0_g1_i1 Q6INU7 FRRS1_XENLA 5.00E-36 GO:0016021; GO:0016491 integral to membrane; oxidoreductase activity IPR006593; IPR005018; IPR002861; Putative ferric-chelate reductase 1 (EC 1.-.-.-) frrs1 Xenopus laevis (African clawed frog) TR24083_c1_g2_i1 Q8VHK2 CSKI1_RAT 3.00E-06 GO:0005737; GO:0019904; GO:0007165 Q9NYB9 cytoplasm; protein domain specific binding; signal transduction IPR002110; IPR020683; IPR027013; IPR027001; IPR001660; IPR013761; IPR021129; IPR011511; IPR001452; Caskin-1 (CASK-interacting protein 1) Caskin1 Rattus norvegicus (Rat) TR24087_c0_g1_i1 Q60648 SAP3_MOUSE 4.00E-11 GO:0004563; GO:0008047; GO:0006689; GO:0007611; GO:0019915; GO:0005764; GO:0005739; GO:0050885; GO:0005730; GO:0009313 beta-N-acetylhexosaminidase activity; enzyme activator activity; ganglioside catabolic process; learning or memory; lipid storage; lysosome; mitochondrion; neuromuscular process controlling balance; nucleolus; oligosaccharide catabolic process IPR003172; Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) Gm2a Mus musculus (Mouse) TR24089_c0_g1_i1 Q6UWX4 HIPL2_HUMAN 2.00E-26 GO:0005975; GO:0005576; GO:0016901; GO:0048038 "carbohydrate metabolic process; extracellular region; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor; quinone binding" IPR011042; IPR018143; IPR012938; IPR011041; HHIP-like protein 2 HHIPL2 HHIP3 KIAA1822L UNQ841/PRO1779 Homo sapiens (Human) TR24089_c1_g1_i1 Q96JK4 HIPL1_HUMAN 2.00E-26 GO:0005975; GO:0005576; GO:0016020; GO:0016901; GO:0048038; GO:0005044 "carbohydrate metabolic process; extracellular region; membrane; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor; quinone binding; scavenger receptor activity" IPR011042; IPR018143; IPR012938; IPR011041; IPR001190; IPR017448; HHIP-like protein 1 HHIPL1 HHIP2 KIAA1822 UNQ9245/PRO34761 Homo sapiens (Human) TR24090_c0_g1_i1 Q9Y234 LIPT_HUMAN 1.00E-18 GO:0006464; GO:0006629; GO:0005739; GO:0009249; GO:0016746 "cellular protein modification process; lipid metabolic process; mitochondrion; protein lipoylation; transferase activity, transferring acyl groups" IPR004143; IPR004562; Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2. "Lipoyltransferase 1, mitochondrial (EC 2.3.1.-) (Lipoate biosynthesis protein) (Lipoate-protein ligase) (Lipoyl ligase)" LIPT1 Homo sapiens (Human) TR24090_c1_g1_i1 C0Q7M8 LPLA_SALPC 2.00E-08 GO:0005524; GO:0005737; GO:0016979; GO:0018055; GO:0016740 ATP binding; cytoplasm; lipoate-protein ligase activity; peptidyl-lysine lipoylation; transferase activity IPR004143; IPR023741; IPR019491; IPR004562; Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2. Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2. Lipoate-protein ligase A (EC 2.7.7.63) (Lipoate--protein ligase) lplA SPC_4708 Salmonella paratyphi C (strain RKS4594) TR24091_c0_g1_i1 Q9Y3E0 GOT1B_HUMAN 5.00E-46 GO:0000139; GO:0005783; GO:0016021; GO:0043123; GO:0015031; GO:0004871; GO:0016192 Golgi membrane; endoplasmic reticulum; integral to membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein transport; signal transducer activity; vesicle-mediated transport IPR007305; Vesicle transport protein GOT1B (Germ cell tumor 2) (Golgi transport 1 homolog B) (Putative NF-kappa-B-activating protein 470) (hGOT1a) GOLT1B GCT2 GOT1A CGI-141 HDCMA39P UNQ432/PRO793 Homo sapiens (Human) TR24091_c0_g1_i2 Q20263 GOT1_CAEEL 1.00E-33 GO:0000139; GO:0016021; GO:0015031; GO:0016192 Golgi membrane; integral to membrane; protein transport; vesicle-mediated transport IPR007305; Probable Golgi transport protein 1 F41C3.4 Caenorhabditis elegans TR24105_c0_g1_i1 O02740 GUC2F_BOVIN 1.00E-16 GO:0005524; GO:0005525; GO:0004383; GO:0016021; GO:0035556; GO:0004672; GO:0007601 ATP binding; GTP binding; guanylate cyclase activity; integral to membrane; intracellular signal transduction; protein kinase activity; visual perception IPR001054; IPR018297; IPR001828; IPR011645; IPR011009; IPR028082; IPR000719; IPR001245; "Retinal guanylyl cyclase 2 (RETGC-2) (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (Guanylate cyclase F) (GC-F) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2)" GUCY2F GUC2F Bos taurus (Bovine) TR24105_c1_g1_i1 O19179 GUC2D_CANFA 8.00E-17 GO:0005524; GO:0005525; GO:0004383; GO:0016021; GO:0035556; GO:0004672; GO:0007601 ATP binding; GTP binding; guanylate cyclase activity; integral to membrane; intracellular signal transduction; protein kinase activity; visual perception IPR001054; IPR018297; IPR001828; IPR011645; IPR011009; IPR028082; IPR000719; IPR001245; "Retinal guanylyl cyclase 1 (RETGC-1) (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (Guanylate cyclase E) (GC-E) (Rod outer segment membrane guanylate cyclase) (ROS-GC)" GUCY2D GUC2D Canis familiaris (Dog) (Canis lupus familiaris) TR24108_c3_g1_i1 Q9JLI3 MMEL1_MOUSE 1.00E-141 GO:0005794; GO:0005783; GO:0005615; GO:0016021; GO:0004222; GO:0006508; GO:0008270 Golgi apparatus; endoplasmic reticulum; extracellular space; integral to membrane; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR000718; IPR018497; IPR008753; "Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) (Neprilysin-like 1) (NL-1) (Neprilysin-like peptidase) (NEPLP) (Soluble secreted endopeptidase) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]" Mmel1 Nep2 Nl1 Sep Mus musculus (Mouse) TR24112_c0_g1_i1 Q86VD9 PIGZ_HUMAN 4.00E-44 GO:0006506; GO:0000026; GO:0005783; GO:0005789; GO:0016021 "GPI anchor biosynthetic process; alpha-1,2-mannosyltransferase activity; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane" IPR005599; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. GPI mannosyltransferase 4 (EC 2.4.1.-) (GPI mannosyltransferase IV) (GPI-MT-IV) (Phosphatidylinositol-glycan biosynthesis class Z protein) (PIG-Z) (SMP3 homolog) (hSMP3) PIGZ SMP3 Homo sapiens (Human) TR24115_c0_g1_i1 Q8BNA6 FAT3_MOUSE 8.00E-13 GO:0005509; GO:0007156; GO:0016021; GO:0007275; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; multicellular organismal development; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Protocadherin Fat 3 (FAT tumor suppressor homolog 3) Fat3 Gm1132 Gm510 Mus musculus (Mouse) TR24115_c0_g2_i1 Q9NL29 EAT20_CAEEL 1.00E-07 GO:0030424; GO:0009986; GO:0016021 axon; cell surface; integral to membrane IPR000742; IPR013032; IPR003645; Abnormal pharyngeal pumping eat-20 eat-20 H30A04.1 Caenorhabditis elegans TR24115_c1_g1_i1 Q0WYX8 MDGA1_CHICK 9.00E-10 GO:0046658; GO:0001764 anchored to plasma membrane; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 MDGA1 Gallus gallus (Chicken) TR24118_c2_g1_i1 Q9QZ05 E2AK4_MOUSE 1.00E-38 GO:0005524; GO:0009267; GO:0022626; GO:0030968; GO:0004694; GO:0017148; GO:0043558 ATP binding; cellular response to starvation; cytosolic ribosome; endoplasmic reticulum unfolded protein response; eukaryotic translation initiation factor 2alpha kinase activity; negative regulation of translation; regulation of translational initiation in response to stress IPR004154; IPR024435; IPR011009; IPR000719; IPR017441; IPR006575; IPR008271; IPR016255; IPR016135; Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2) Eif2ak4 Gcn2 Kiaa1338 Mus musculus (Mouse) TR24120_c1_g1_i1 O18499 ACT1_SACKO 2.00E-164 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; Actin-1 Saccoglossus kowalevskii (Acorn worm) TR24120_c1_g2_i1 Q09849 ARP42_SCHPO 1.00E-27 GO:0016586; GO:0016514; GO:0006338; GO:0005829; GO:0000122; GO:0000790; GO:0045944; GO:0010570; GO:0006351 "RSC complex; SWI/SNF complex; chromatin remodeling; cytosol; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; positive regulation of transcription from RNA polymerase II promoter; regulation of filamentous growth; transcription, DNA-dependent" IPR004000; IPR004001; SWI/SNF and RSC complexes subunit arp42 (Actin-related protein 42) (Chromatin structure-remodeling complex subunit arp42) arp42 arp4 SPAC23D3.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR24121_c1_g1_i1 O75618 DEDD_HUMAN 7.00E-33 GO:0003677; GO:0005737; GO:0046697; GO:0008625; GO:0042177; GO:0045892; GO:0005730; GO:0042981; GO:0007283; GO:0006351 Q06481 "DNA binding; cytoplasm; decidualization; extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of protein catabolic process; negative regulation of transcription, DNA-dependent; nucleolus; regulation of apoptotic process; spermatogenesis; transcription, DNA-dependent" IPR011029; IPR001875; Death effector domain-containing protein (DEDPro1) (Death effector domain-containing testicular molecule) (FLDED-1) DEDD DEDPRO1 DEFT KE05 Homo sapiens (Human) TR24127_c0_g2_i1 Q9UKL6 PPCT_HUMAN 3.00E-13 GO:0008203; GO:0005829; GO:0031210; GO:0008525 cholesterol metabolic process; cytosol; phosphatidylcholine binding; phosphatidylcholine transporter activity IPR023393; IPR002913; Phosphatidylcholine transfer protein (PC-TP) (START domain-containing protein 2) (StARD2) (StAR-related lipid transfer protein 2) PCTP STARD2 Homo sapiens (Human) TR24127_c0_g3_i1 Q9NQZ5 STAR7_HUMAN 1.00E-51 GO:0008289; GO:0005739 lipid binding; mitochondrion IPR023393; IPR002913; "StAR-related lipid transfer protein 7, mitochondrial (Gestational trophoblastic tumor protein 1) (START domain-containing protein 7) (StARD7)" STARD7 GTT1 Homo sapiens (Human) TR24128_c0_g1_i1 Q8TC29 ENKUR_HUMAN 2.00E-78 GO:0005929 cilium IPR026150; IPR027012; Enkurin ENKUR C10orf63 Homo sapiens (Human) TR24128_c0_g1_i2 Q8TC29 ENKUR_HUMAN 4.00E-75 GO:0005929 cilium IPR026150; IPR027012; Enkurin ENKUR C10orf63 Homo sapiens (Human) TR2413_c0_g1_i1 O42563 CP3AR_ONCMY 3.00E-19 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR008072; IPR002402; Cytochrome P450 3A27 (EC 1.14.14.1) (CYPIIIA27) cyp3a27 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR24130_c0_g1_i1 Q13045 FLII_HUMAN 3.00E-98 GO:0003779; GO:0005813; GO:0005737; GO:0005925; GO:0007275; GO:0006936; GO:0005634; GO:0006355; GO:0006351 Q32MZ4 "actin binding; centrosome; cytoplasm; focal adhesion; multicellular organismal development; muscle contraction; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007123; IPR001611; IPR025875; IPR003591; IPR007122; Protein flightless-1 homolog FLII FLIL Homo sapiens (Human) TR24131_c0_g1_i1 P54276 MSH6_MOUSE 3.00E-28 GO:0043531; GO:0005524; GO:0008094; GO:0032301; GO:0003682; GO:0003684; GO:0008340; GO:0000400; GO:0032137; GO:0008630; GO:0045190; GO:0000287; GO:0043570; GO:0000710; GO:0035064; GO:0045910; GO:0000790; GO:0032357; GO:0051096; GO:0007131; GO:0009411; GO:0032138; GO:0032142; GO:0032143; GO:0016446 ADP binding; ATP binding; DNA-dependent ATPase activity; MutSalpha complex; chromatin binding; damaged DNA binding; determination of adult lifespan; four-way junction DNA binding; guanine/thymine mispair binding; intrinsic apoptotic signaling pathway in response to DNA damage; isotype switching; magnesium ion binding; maintenance of DNA repeat elements; meiotic mismatch repair; methylated histone residue binding; negative regulation of DNA recombination; nuclear chromatin; oxidized purine DNA binding; positive regulation of helicase activity; reciprocal meiotic recombination; response to UV; single base insertion or deletion binding; single guanine insertion binding; single thymine insertion binding; somatic hypermutation of immunoglobulin genes IPR017261; IPR015536; IPR007695; IPR000432; IPR007861; IPR007696; IPR016151; IPR007860; IPR027417; IPR000313; DNA mismatch repair protein Msh6 (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS-alpha 160 kDa subunit) (p160) Msh6 Gtmbp Mus musculus (Mouse) TR24134_c2_g1_i1 P30729 DRD4_RAT 2.00E-08 GO:0007195; GO:0008344; GO:0001662; GO:0048148; GO:0005938; GO:0007623; GO:0043197; GO:0035240; GO:0001591; GO:0008144; GO:0005887; GO:0007626; GO:0043025; GO:0008355; GO:0009648; GO:0005886; GO:2000463; GO:0060406; GO:0050848; GO:0042053; GO:0060080; GO:0046928; GO:0001975; GO:0048545; GO:0060041; GO:0007614; GO:0001963; GO:0043195; GO:0012506 "adenylate cyclase-inhibiting dopamine receptor signaling pathway; adult locomotory behavior; behavioral fear response; behavioral response to cocaine; cell cortex; circadian rhythm; dendritic spine; dopamine binding; dopamine neurotransmitter receptor activity, coupled via Gi/Go; drug binding; integral to plasma membrane; locomotory behavior; neuronal cell body; olfactory learning; photoperiodism; plasma membrane; positive regulation of excitatory postsynaptic membrane potential; positive regulation of penile erection; regulation of calcium-mediated signaling; regulation of dopamine metabolic process; regulation of inhibitory postsynaptic membrane potential; regulation of neurotransmitter secretion; response to amphetamine; response to steroid hormone stimulus; retina development in camera-type eye; short-term memory; synaptic transmission, dopaminergic; terminal bouton; vesicle membrane" IPR002185; IPR000929; IPR000276; IPR017452; D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor) Drd4 Rattus norvegicus (Rat) TR24134_c3_g1_i1 P08909 5HT2C_RAT 2.00E-10 GO:0007187; GO:0001587; GO:0001662; GO:0035095; GO:0051482; GO:0009897; GO:0007631; GO:0048016; GO:0005887; GO:0007626; GO:0045963; GO:0040013; GO:0031100; GO:0007208; GO:0031583; GO:0014057; GO:0014054; GO:0045907; GO:0032098; GO:0043397; GO:0051930; GO:0042493 "G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; Gq/11-coupled serotonin receptor activity; behavioral fear response; behavioral response to nicotine; elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; external side of plasma membrane; feeding behavior; inositol phosphate-mediated signaling; integral to plasma membrane; locomotory behavior; negative regulation of dopamine metabolic process; negative regulation of locomotion; organ regeneration; phospholipase C-activating serotonin receptor signaling pathway; phospholipase D-activating G-protein coupled receptor signaling pathway; positive regulation of acetylcholine secretion, neurotransmission; positive regulation of gamma-aminobutyric acid secretion; positive regulation of vasoconstriction; regulation of appetite; regulation of corticotropin-releasing hormone secretion; regulation of sensory perception of pain; response to drug" IPR000377; IPR002231; IPR000276; IPR017452; 5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C) Htr2c 5ht1c Htr1c Rattus norvegicus (Rat) TR24138_c0_g1_i1 P36110 PRY2_YEAST 4.00E-15 GO:0005576; GO:0032934; GO:0015918 extracellular region; sterol binding; sterol transport IPR001283; IPR018244; IPR014044; Protein PRY2 (Pathogen related in Sc 2) PRY2 YKR013W YK111 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR24138_c0_g1_i3 Q9H4G4 GAPR1_HUMAN 1.00E-30 GO:0000139; GO:0005576 Golgi membrane; extracellular region IPR001283; IPR018244; IPR014044; Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) GLIPR2 C9orf19 GAPR1 Homo sapiens (Human) TR24139_c3_g1_i1 P49193 RALB_TODPA 6.00E-20 GO:0016021; GO:0050896; GO:0006810; GO:0007601 integral to membrane; response to stimulus; transport; visual perception IPR001251; IPR009038; Retinal-binding protein (RALBP) Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus) TR24145_c0_g1_i1 Q922R0 PRKX_MOUSE 2.00E-154 GO:0005524; GO:0001525; GO:0004691; GO:0031589; GO:0005737; GO:0043542; GO:0001935; GO:0060562; GO:0060993; GO:0030099; GO:0005634; GO:0018105; GO:0046777; GO:0030155; GO:0030334; GO:2000696 ATP binding; angiogenesis; cAMP-dependent protein kinase activity; cell-substrate adhesion; cytoplasm; endothelial cell migration; endothelial cell proliferation; epithelial tube morphogenesis; kidney morphogenesis; myeloid cell differentiation; nucleus; peptidyl-serine phosphorylation; protein autophosphorylation; regulation of cell adhesion; regulation of cell migration; regulation of epithelial cell differentiation involved in kidney development IPR000961; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (PKA-related protein kinase) Prkx Pkare Mus musculus (Mouse) TR24146_c4_g1_i1 O95863 SNAI1_HUMAN 1.00E-11 GO:0061314; GO:0001078; GO:0060536; GO:0016477; GO:0005737; GO:0001837; GO:0031069; GO:0060972; GO:0001707; GO:0046872; GO:0043518; GO:0060806; GO:1902230; GO:0010957; GO:0005634; GO:0001649; GO:0060021; GO:0030335; GO:0010718; GO:0045893; GO:2000810; GO:0043565; GO:0060707 Q9Y297; P49841; O60341; P09874; P04637 "Notch signaling involved in heart development; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; cartilage morphogenesis; cell migration; cytoplasm; epithelial to mesenchymal transition; hair follicle morphogenesis; left/right pattern formation; mesoderm formation; metal ion binding; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of cell differentiation involved in embryonic placenta development; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of vitamin D biosynthetic process; nucleus; osteoblast differentiation; palate development; positive regulation of cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of transcription, DNA-dependent; regulation of tight junction assembly; sequence-specific DNA binding; trophoblast giant cell differentiation" IPR007087; IPR015880; IPR013087; Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna) SNAI1 SNAH Homo sapiens (Human) TR24146_c4_g1_i2 O95863 SNAI1_HUMAN 9.00E-12 GO:0061314; GO:0001078; GO:0060536; GO:0016477; GO:0005737; GO:0001837; GO:0031069; GO:0060972; GO:0001707; GO:0046872; GO:0043518; GO:0060806; GO:1902230; GO:0010957; GO:0005634; GO:0001649; GO:0060021; GO:0030335; GO:0010718; GO:0045893; GO:2000810; GO:0043565; GO:0060707 Q9Y297; P49841; O60341; P09874; P04637 "Notch signaling involved in heart development; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; cartilage morphogenesis; cell migration; cytoplasm; epithelial to mesenchymal transition; hair follicle morphogenesis; left/right pattern formation; mesoderm formation; metal ion binding; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of cell differentiation involved in embryonic placenta development; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of vitamin D biosynthetic process; nucleus; osteoblast differentiation; palate development; positive regulation of cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of transcription, DNA-dependent; regulation of tight junction assembly; sequence-specific DNA binding; trophoblast giant cell differentiation" IPR007087; IPR015880; IPR013087; Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna) SNAI1 SNAH Homo sapiens (Human) TR24148_c2_g1_i1 Q5SPX1 CC157_MOUSE 3.00E-16 Coiled-coil domain-containing protein 157 Ccdc157 Kiaa1656 Mus musculus (Mouse) TR24152_c0_g1_i1 P29503 NEUR_DROME 2.00E-25 GO:0003677; GO:0008356; GO:0048854; GO:0048749; GO:0005829; GO:0007398; GO:0030718; GO:0007476; GO:0002121; GO:0046331; GO:0031987; GO:0007616; GO:0007498; GO:0005634; GO:0042048; GO:0030707; GO:0048471; GO:0007422; GO:1901981; GO:0005886; GO:0045747; GO:0051260; GO:0008104; GO:0045314; GO:0016360; GO:0001964; GO:0004842; GO:0008270 DNA binding; asymmetric cell division; brain morphogenesis; compound eye development; cytosol; ectoderm development; germ-line stem cell maintenance; imaginal disc-derived wing morphogenesis; inter-male aggressive behavior; lateral inhibition; locomotion involved in locomotory behavior; long-term memory; mesoderm development; nucleus; olfactory behavior; ovarian follicle cell development; perinuclear region of cytoplasm; peripheral nervous system development; phosphatidylinositol phosphate binding; plasma membrane; positive regulation of Notch signaling pathway; protein homooligomerization; protein localization; regulation of compound eye photoreceptor development; sensory organ precursor cell fate determination; startle response; ubiquitin-protein ligase activity; zinc ion binding IPR006573; IPR001841; IPR013083; Protein neuralized neur neu CG11988 Drosophila melanogaster (Fruit fly) TR24156_c1_g1_i2 Q5R541 GEM_PONAB 4.00E-27 GO:0005525; GO:0003924; GO:0005886; GO:0007264 GTP binding; GTPase activity; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR017358; IPR020849; GTP-binding protein GEM GEM Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR24161_c0_g1_i1 Q5R1W4 TBA1B_PANTR 1.00E-29 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-1B chain (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) TUBA1B Pan troglodytes (Chimpanzee) TR24164_c6_g1_i1 Q62902 LMAN1_RAT 3.00E-83 GO:0006888; GO:0005794; GO:0000139; GO:0005509; GO:0005783; GO:0005789; GO:0005793; GO:0033116; GO:0042802; GO:0016021; GO:0005537; GO:0015031 ER to Golgi vesicle-mediated transport; Golgi apparatus; Golgi membrane; calcium ion binding; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; identical protein binding; integral to membrane; mannose binding; protein transport IPR008985; IPR013320; IPR005052; Protein ERGIC-53 (ER-Golgi intermediate compartment 53 kDa protein) (Lectin mannose-binding 1) (p58) Lman1 Ergic53 Rattus norvegicus (Rat) TR24168_c2_g1_i1 Q96BN6 F149B_HUMAN 7.00E-06 IPR022194; Protein FAM149B1 FAM149B1 KIAA0974 Homo sapiens (Human) TR24168_c4_g1_i1 A1L253 F149B_DANRE 6.00E-18 IPR022194; Protein FAM149B1 fam149b1 zgc:158651 Danio rerio (Zebrafish) (Brachydanio rerio) TR24172_c1_g1_i1 Q8IYT3 CC170_HUMAN 9.00E-07 Coiled-coil domain-containing protein 170 CCDC170 C6orf97 Homo sapiens (Human) TR24173_c1_g1_i2 Q96MM6 HS12B_HUMAN 2.00E-15 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR24175_c0_g1_i1 Q54468 CHB_SERMA 2.00E-13 GO:0004563; GO:0006032; GO:0042597; GO:0030247; GO:0000272 beta-N-acetylhexosaminidase activity; chitin catabolic process; periplasmic space; polysaccharide binding; polysaccharide catabolic process IPR025705; IPR008965; IPR012291; IPR004866; IPR004867; IPR013812; IPR015883; IPR015882; IPR013781; IPR017853; IPR014756; Glycan degradation; chitin degradation. Chitobiase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (N-acetyl-beta-glucosaminidase) chb Serratia marcescens TR24175_c1_g1_i1 Q04786 HEX_VIBVL 3.00E-15 GO:0004563; GO:0006032; GO:0030247; GO:0000272 beta-N-acetylhexosaminidase activity; chitin catabolic process; polysaccharide binding; polysaccharide catabolic process IPR025705; IPR008965; IPR012291; IPR004866; IPR013812; IPR015883; IPR015882; IPR013781; IPR017853; IPR014756; Glycan degradation; chitin degradation. Beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Chitobiase) (N-acetyl-beta-glucosaminidase) hex Vibrio vulnificus TR24178_c1_g1_i1 E1BCH6 ISPD_BOVIN 9.00E-61 GO:0008299; GO:0016779; GO:0035269 isoprenoid biosynthetic process; nucleotidyltransferase activity; protein O-linked mannosylation IPR001228; IPR018294; Protein modification; protein glycosylation. Isoprenoid synthase domain-containing protein (EC 2.7.7.-) (2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein) ISPD Bos taurus (Bovine) TR24182_c1_g1_i1 Q7Z9I2 YCP9_SCHPO 5.00E-23 GO:0005829; GO:0005634; GO:0016491 cytosol; nucleus; oxidoreductase activity IPR002198; IPR002347; IPR016040; Uncharacterized oxidoreductase C663.09c (EC 1.-.-.-) SPCC663.09c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR24183_c0_g1_i1 P86179 CSL3_ONCKE 6.00E-25 GO:0030246 carbohydrate binding IPR000922; L-rhamnose-binding lectin CSL3 Oncorhynchus keta (Chum salmon) (Salmo keta) TR24183_c0_g1_i2 Q9PVW8 SAL_SILAS 4.00E-23 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR000922; Rhamnose-binding lectin (RBL) (Roe lectin) (SAL) Silurus asotus (Amur catfish) (Parasilurus asotus) TR24187_c0_g1_i1 Q17QS4 PI5L1_BOVIN 4.00E-11 GO:0016308; GO:0005524; GO:0005737; GO:0016020; GO:0046854 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding; cytoplasm; membrane; phosphatidylinositol phosphorylation IPR023610; IPR027483; IPR002498; IPR027484; Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PI(4)P 5-kinase-like protein 1) (PtdIns(4)P-5-kinase-like protein 1) (EC 2.7.1.68) PIP5KL1 Bos taurus (Bovine) TR2419_c0_g1_i1 Q9VEW2 SERFL_DROME 1.00E-06 IPR007513; Putative SERF-like protein CG17931 Drosophila melanogaster (Fruit fly) TR24191_c0_g1_i1 O15164 TIF1A_HUMAN 3.00E-10 GO:0055074; GO:0071391; GO:0003682; GO:0005829; GO:0034056; GO:0070577; GO:0008285; GO:0045892; GO:0005719; GO:0005634; GO:0005726; GO:0045893; GO:0046777; GO:0030163; GO:0004672; GO:0005102; GO:0042981; GO:0031647; GO:0070562; GO:0043565; GO:0003713; GO:0006366; GO:0004842; GO:0008270 "calcium ion homeostasis; cellular response to estrogen stimulus; chromatin binding; cytosol; estrogen response element binding; histone acetyl-lysine binding; negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nucleus; perichromatin fibrils; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein catabolic process; protein kinase activity; receptor binding; regulation of apoptotic process; regulation of protein stability; regulation of vitamin D receptor signaling pathway; sequence-specific DNA binding; transcription coactivator activity; transcription from RNA polymerase II promoter; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR018359; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (Tripartite motif-containing protein 24) TRIM24 RNF82 TIF1 TIF1A Homo sapiens (Human) TR24191_c0_g1_i2 Q80VI1 TRI56_MOUSE 9.00E-16 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) TR24192_c2_g1_i1 Q8K442 ABC8A_MOUSE 2.00E-30 GO:0005524; GO:0006200; GO:0016887; GO:0016021; GO:0005886; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; integral to membrane; plasma membrane; transport IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 8-A Abca8a Mus musculus (Mouse) TR24192_c3_g1_i1 Q84M24 AB1A_ARATH 4.00E-31 GO:0005524; GO:0006200; GO:0016887; GO:0016021; GO:0006810; GO:0005774 ATP binding; ATP catabolic process; ATPase activity; integral to membrane; transport; vacuolar membrane IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ABC transporter A family member 1 (ABC transporter ABCA.1) (AtABCA1) (ABC one homolog protein 1) (AtAOH1) ABCA1 ABC1 AOH1 At2g41700 T32G6.22 Arabidopsis thaliana (Mouse-ear cress) TR24192_c5_g1_i1 Q99758 ABCA3_HUMAN 1.00E-49 GO:0005524; GO:0042626; GO:0097208; GO:0097233; GO:0016021; GO:0005886; GO:0042493 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; alveolar lamellar body; alveolar lamellar body membrane; integral to membrane; plasma membrane; response to drug" IPR003593; IPR026082; IPR003439; IPR017871; IPR026969; IPR027417; ATP-binding cassette sub-family A member 3 (ABC-C transporter) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) ABCA3 ABC3 Homo sapiens (Human) TR24192_c6_g1_i2 Q58429 Y1023_METJA 1.00E-08 GO:0005524; GO:0006200; GO:0016887; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; transport IPR003593; IPR003439; IPR017871; IPR027417; Uncharacterized ABC transporter ATP-binding protein MJ1023 MJ1023 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR24194_c0_g1_i1 Q7Z4K8 TRI46_HUMAN 9.00E-09 GO:0005622; GO:0008270 intracellular; zinc ion binding IPR001870; IPR008985; IPR017903; IPR003961; IPR013783; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; "Tripartite motif-containing protein 46 (Gene Y protein) (GeneY) (Tripartite, fibronectin type-III and C-terminal SPRY motif protein)" TRIM46 TRIFIC Homo sapiens (Human) TR24194_c0_g2_i1 P31721 C1QB_RAT 5.00E-08 GO:0007568; GO:0007420; GO:0005581; GO:0006958; GO:0005602; GO:0006955; GO:0045087; GO:0051384 "aging; brain development; collagen; complement activation, classical pathway; complement component C1 complex; immune response; innate immune response; response to glucocorticoid stimulus" IPR001073; IPR008160; IPR008983; Complement C1q subcomponent subunit B C1qb Rattus norvegicus (Rat) TR24197_c3_g1_i1 A8MT70 ZBBX_HUMAN 1.00E-19 GO:0005622; GO:0008270 intracellular; zinc ion binding IPR000315; Zinc finger B-box domain-containing protein 1 ZBBX Homo sapiens (Human) TR24199_c1_g3_i1 P83425 HIP_MYTED 4.00E-09 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR24199_c1_g3_i4 Q8CFR0 C1QL2_MOUSE 1.00E-05 GO:0005581; GO:0005576; GO:0042802; GO:0051259 collagen; extracellular region; identical protein binding; protein oligomerization IPR001073; IPR008160; IPR008983; Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) (C1qTNF10) (CTRP10) C1ql2 C1qtnf10 Ctrp10 Mus musculus (Mouse) TR24206_c0_g1_i1 P30568 GSTA_PLEPL 3.00E-61 GO:0005737; GO:0004364 cytoplasm; glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase A (GST-A) (EC 2.5.1.18) (GST class-theta) Pleuronectes platessa (European plaice) TR24208_c1_g1_i1 B3A0Q8 PLSP2_LOTGI 3.00E-24 GO:0005576; GO:0020037; GO:0004601; GO:0006979 extracellular region; heme binding; peroxidase activity; response to oxidative stress IPR010255; IPR002007; IPR019791; Peroxidase-like protein 3 (Fragment) Lottia gigantea (Giant owl limpet) TR24209_c0_g1_i1 Q9W740 NOGG2_DANRE 2.00E-33 GO:0051216; GO:0030154; GO:0005576; GO:0030514; GO:0045596 cartilage development; cell differentiation; extracellular region; negative regulation of BMP signaling pathway; negative regulation of cell differentiation IPR008717; Noggin-2 nog2 Danio rerio (Zebrafish) (Brachydanio rerio) TR24215_c0_g2_i1 Q8IZJ3 CPMD8_HUMAN 6.00E-60 GO:0005615; GO:0010951; GO:0005886; GO:0004867 extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR002350; IPR001599; IPR019742; IPR019565; IPR022041; IPR008930; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 CPAMD8 KIAA1283 Homo sapiens (Human) TR24215_c1_g1_i1 P01029 CO4B_MOUSE 2.00E-13 GO:0006958; GO:0004866; GO:0005615; GO:0006954; GO:0045087; GO:0010951 "complement activation, classical pathway; endopeptidase inhibitor activity; extracellular space; inflammatory response; innate immune response; negative regulation of endopeptidase activity" IPR009048; IPR011626; IPR002890; IPR011625; IPR000020; IPR018081; IPR001840; IPR001599; IPR019742; IPR019565; IPR001134; IPR018933; IPR008930; IPR008993; Complement C4-B [Cleaved into: Complement C4 beta chain; Complement C4 alpha chain; C4a anaphylatoxin; Complement C4 gamma chain] C4b C4 Mus musculus (Mouse) TR24218_c1_g2_i1 Q05360 WHITE_LUCCU 3.00E-42 GO:0005524; GO:0006200; GO:0016887; GO:0016021; GO:0031409; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; integral to membrane; pigment binding; transport IPR003593; IPR013525; IPR003439; IPR017871; IPR027417; IPR005284; Protein white W Lucilia cuprina (Green bottle fly) (Australian sheep blowfly) TR24223_c1_g1_i1 Q9VZW5 FMAR_DROME 7.00E-06 GO:0002209; GO:0007204; GO:0005887; GO:0008345; GO:0008188 behavioral defense response; elevation of cytosolic calcium ion concentration; integral to plasma membrane; larval locomotory behavior; neuropeptide receptor activity IPR000276; IPR017452; FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) TR24224_c0_g1_i1 P63102 1433Z_RAT 1.00E-87 GO:0031252; GO:0002553; GO:0042470; GO:0005739; GO:0048471; GO:0014069; GO:0043234; GO:0019904; GO:0006626 cell leading edge; histamine secretion by mast cell; melanosome; mitochondrion; perinuclear region of cytoplasm; postsynaptic density; protein complex; protein domain specific binding; protein targeting to mitochondrion IPR000308; IPR023409; IPR023410; 14-3-3 protein zeta/delta (Mitochondrial import stimulation factor S1 subunit) (Protein kinase C inhibitor protein 1) (KCIP-1) Ywhaz Msfs1 Rattus norvegicus (Rat) TR24229_c0_g1_i1 P20825 POL2_DROME 4.00E-52 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR24231_c1_g1_i1 Q9JJC8 NIPA2_MOUSE 1.00E-68 GO:0005769; GO:0016021; GO:0015095; GO:0015693; GO:0005886 early endosome; integral to membrane; magnesium ion transmembrane transporter activity; magnesium ion transport; plasma membrane IPR008521; Magnesium transporter NIPA2 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog) Nipa2 MNCb-2146 Mus musculus (Mouse) TR24237_c1_g1_i1 Q8TBZ3 WDR20_HUMAN 0 IPR015943; IPR001680; IPR017986; WD repeat-containing protein 20 (Protein DMR) WDR20 Homo sapiens (Human) TR24238_c2_g1_i1 Q9NUV9 GIMA4_HUMAN 3.00E-06 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR24245_c0_g1_i1 Q6R5N8 TLR13_MOUSE 6.00E-09 GO:0002755; GO:0005768; GO:0010008; GO:0006954; GO:0045087; GO:0016021; GO:0042803; GO:0019843; GO:0043408; GO:0002237; GO:0009615; GO:0034178; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; endosome; endosome membrane; inflammatory response; innate immune response; integral to membrane; protein homodimerization activity; rRNA binding; regulation of MAPK cascade; response to molecule of bacterial origin; response to virus; toll-like receptor 13 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR003591; IPR000157; IPR027196; Toll-like receptor 13 Tlr13 Mus musculus (Mouse) TR24247_c0_g1_i1 Q6GQT0 CC14A_MOUSE 7.00E-09 GO:0007049; GO:0051301; GO:0005737; GO:0005815; GO:0005634; GO:0035335; GO:0004725; GO:0008138; GO:0005819 cell cycle; cell division; cytoplasm; microtubule organizing center; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; spindle IPR000340; IPR020422; IPR026068; IPR000387; IPR016130; Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) Cdc14a Mus musculus (Mouse) TR24247_c0_g1_i3 Q6NT99 DUS23_MOUSE 2.00E-28 GO:0005829; GO:0005634; GO:0035335; GO:0004725; GO:0008138 cytosol; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR016130; Dual specificity protein phosphatase 23 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular mass dual specificity phosphatase 3) (LDP-3) Dusp23 Ldp3 Mus musculus (Mouse) TR24255_c1_g1_i1 Q8NBP5 MFSD9_HUMAN 3.00E-06 GO:0016021; GO:0005886; GO:0055085; GO:0005215 integral to membrane; plasma membrane; transmembrane transport; transporter activity IPR011701; IPR020846; IPR016196; IPR005829; IPR001958; Major facilitator superfamily domain-containing protein 9 MFSD9 PSEC0066 Homo sapiens (Human) TR24260_c0_g1_i2 Q86QN6 BDEF_BRABE 1.00E-16 GO:0050829; GO:0050830; GO:0050832; GO:0005576; GO:0031640 defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; defense response to fungus; extracellular region; killing of cells of other organism IPR028060; Big defensin (Defensin) Branchiostoma belcheri (Amphioxus) TR24262_c0_g1_i1 Q60755 CALCR_MOUSE 1.00E-09 GO:0001669; GO:0007189; GO:0004948; GO:0005929; GO:0007204; GO:0016021; GO:0030279; GO:0030316; GO:0005886; GO:0043488 acrosomal vesicle; adenylate cyclase-activating G-protein coupled receptor signaling pathway; calcitonin receptor activity; cilium; elevation of cytosolic calcium ion concentration; integral to membrane; negative regulation of ossification; osteoclast differentiation; plasma membrane; regulation of mRNA stability IPR003287; IPR017981; IPR001688; IPR001879; IPR000832; IPR017983; Calcitonin receptor (CT-R) Calcr Mus musculus (Mouse) TR24262_c2_g2_i2 Q68EK2 CALRL_DANRE 4.00E-31 GO:0001525; GO:0048844; GO:0004948; GO:0016021; GO:0005886; GO:0001756 angiogenesis; artery morphogenesis; calcitonin receptor activity; integral to membrane; plasma membrane; somitogenesis IPR003287; IPR017981; IPR003289; IPR001879; IPR000832; IPR017983; Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) calcrla calcrl si:dkey-249o24.2 zgc:100872 Danio rerio (Zebrafish) (Brachydanio rerio) TR24263_c0_g1_i1 Q2L897 QCR8_AILME 1.00E-15 GO:0021680; GO:0021766; GO:0021854; GO:0030901; GO:0005743; GO:0021548; GO:0021860; GO:0070469; GO:0021539; GO:0021794; GO:0008121 cerebellar Purkinje cell layer development; hippocampus development; hypothalamus development; midbrain development; mitochondrial inner membrane; pons development; pyramidal neuron development; respiratory chain; subthalamus development; thalamus development; ubiquinol-cytochrome-c reductase activity IPR004205; Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C) UQCRQ Ailuropoda melanoleuca (Giant panda) TR24266_c3_g1_i1 P91621 SIF1_DROME 5.00E-38 GO:0030676; GO:0030054; GO:0035556; GO:0005543; GO:0051491; GO:0005057; GO:0032314; GO:0050770; GO:0050803; GO:0045202 Rac guanyl-nucleotide exchange factor activity; cell junction; intracellular signal transduction; phospholipid binding; positive regulation of filopodium assembly; receptor signaling protein activity; regulation of Rac GTPase activity; regulation of axonogenesis; regulation of synapse structure and activity; synapse IPR000219; IPR001331; IPR001478; IPR011993; IPR001849; IPR003116; IPR000697; "Protein still life, isoform SIF type 1" sif CG34418 Drosophila melanogaster (Fruit fly) TR24278_c0_g2_i2 O46586 COX41_PERPO 2.00E-17 GO:0004129; GO:0005743 cytochrome-c oxidase activity; mitochondrial inner membrane IPR013288; IPR004203; "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) (Fragment)" COX4I1 COX4 Perodicticus potto edwarsi (Potto) TR24279_c1_g1_i1 A0E358 CATL2_PARTE 2.00E-35 GO:0008234; GO:0005576; GO:0006508 cysteine-type peptidase activity; extracellular region; proteolysis IPR000169; IPR013128; IPR000668; IPR013201; Cathepsin L 2 (EC 3.4.22.15) GSPATT00022898001 Paramecium tetraurelia TR24287_c0_g1_i2 P03934 TC1A_CAEEL 3.00E-13 GO:0003677; GO:0015074; GO:0004519; GO:0090305; GO:0005634; GO:0004803; GO:0006313 "DNA binding; DNA integration; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus; transposase activity; transposition, DNA-mediated" IPR002492; Transposable element Tc1 transposase tc1a tca T07D3.8 Caenorhabditis elegans TR24288_c2_g1_i1 Q62671 UBR5_RAT 1.00E-47 GO:0006281; GO:0003723; GO:0005737; GO:2000780; GO:1901315; GO:0005634; GO:0050847; GO:0042787; GO:0006974; GO:0004842; GO:0008270 DNA repair; RNA binding; cytoplasm; negative regulation of double-strand break repair; negative regulation of histone H2A K63-linked ubiquitination; nucleus; progesterone receptor signaling pathway; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; response to DNA damage stimulus; ubiquitin-protein ligase activity; zinc ion binding IPR024725; IPR000569; IPR002004; IPR009091; IPR003126; IPR013993; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase UBR5 (EC 6.3.2.-) (100 kDa protein) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog)" Ubr5 Dd5 Edd Edd1 Hyd Rattus norvegicus (Rat) TR24299_c3_g1_i1 Q4QQS1 T184A_RAT 3.00E-94 GO:0016021 integral to membrane IPR005178; Transmembrane protein 184A Tmem184a Rattus norvegicus (Rat) TR24299_c3_g1_i2 A2VDL9 T184B_BOVIN 2.00E-96 GO:0016021 integral to membrane IPR005178; Transmembrane protein 184B TMEM184B Bos taurus (Bovine) TR24301_c0_g2_i1 Q09225 NRF6_CAEEL 3.00E-14 GO:0016021; GO:0008289; GO:0006869; GO:0007275; GO:0016747 "integral to membrane; lipid binding; lipid transport; multicellular organismal development; transferase activity, transferring acyl groups other than amino-acyl groups" IPR002656; IPR006621; Nose resistant to fluoxetine protein 6 (Protein nrf-6) nrf-6 C08B11.4 Caenorhabditis elegans TR24302_c0_g2_i1 P26584 HMGB2_CHICK 2.00E-21 GO:0008301; GO:0006288; GO:0000793; GO:0005634; GO:0048471; GO:0006357 "DNA binding, bending; base-excision repair, DNA ligation; condensed chromosome; nucleus; perinuclear region of cytoplasm; regulation of transcription from RNA polymerase II promoter" IPR009071; IPR017967; High mobility group protein B2 (High mobility group protein 2) (HMG-2) HMGB2 HMG2 Gallus gallus (Chicken) TR24302_c1_g1_i1 P0C6E5 HMG3M_HUMAN 2.00E-12 GO:0003677; GO:0005694; GO:0005634 DNA binding; chromosome; nucleus IPR009071; IPR017967; Putative high mobility group protein B3-like protein Homo sapiens (Human) TR24305_c0_g1_i1 Q96L50 LLR1_HUMAN 9.00E-87 GO:0016567 protein ubiquitination IPR001611; IPR025875; Protein modification; protein ubiquitination. Leucine-rich repeat protein 1 (4-1BB-mediated-signaling molecule) (4-1BBlrr) (LRR-repeat protein 1) (LRR-1) (Peptidylprolyl isomerase-like 5) LRR1 PPIL5 Homo sapiens (Human) TR24305_c0_g1_i2 Q96L50 LLR1_HUMAN 2.00E-15 GO:0016567 protein ubiquitination IPR001611; IPR025875; Protein modification; protein ubiquitination. Leucine-rich repeat protein 1 (4-1BB-mediated-signaling molecule) (4-1BBlrr) (LRR-repeat protein 1) (LRR-1) (Peptidylprolyl isomerase-like 5) LRR1 PPIL5 Homo sapiens (Human) TR24306_c0_g2_i1 P41824 YBOXH_APLCA 4.00E-31 GO:0003677; GO:0003723; GO:0005634; GO:0006355; GO:0006351 "DNA binding; RNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019844; IPR011129; IPR002059; IPR012340; Y-box factor homolog (APY1) Aplysia californica (California sea hare) TR24307_c1_g1_i1 A2BG43 GLTP_DANRE 1.00E-30 GO:0005737; GO:0051861; GO:0046836; GO:0017089 cytoplasm; glycolipid binding; glycolipid transport; glycolipid transporter activity IPR014830; Glycolipid transfer protein (GLTP) gltp si:dkey-234h16.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR24307_c1_g1_i2 Q6NU44 GLTPB_XENLA 4.00E-27 GO:0005737; GO:0051861; GO:0046836; GO:0017089 cytoplasm; glycolipid binding; glycolipid transport; glycolipid transporter activity IPR014830; Glycolipid transfer protein B (GLTP-B) gltp-b Xenopus laevis (African clawed frog) TR24312_c0_g2_i1 Q80Z30 PPM1E_RAT 4.00E-31 GO:0035690; GO:0046872; GO:0005739; GO:0006469; GO:0005730; GO:0005634; GO:0035970; GO:0051496; GO:0043234; GO:0004722 P05065; P04797 cellular response to drug; metal ion binding; mitochondrion; negative regulation of protein kinase activity; nucleolus; nucleus; peptidyl-threonine dephosphorylation; positive regulation of stress fiber assembly; protein complex; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA) Ppm1e Camkn Rattus norvegicus (Rat) TR24312_c6_g1_i1 O15743 SPNA_DICDI 1.00E-09 GO:0007186; GO:0005525; GO:0006184; GO:0003924; GO:0009653; GO:0030154; GO:0005829; GO:0000287; GO:0030145; GO:0016020; GO:0005886; GO:0006470; GO:0004722; GO:0001726; GO:0004871 G-protein coupled receptor signaling pathway; GTP binding; GTP catabolic process; GTPase activity; anatomical structure morphogenesis; cell differentiation; cytosol; magnesium ion binding; manganese ion binding; membrane; plasma membrane; protein dephosphorylation; protein serine/threonine phosphatase activity; ruffle; signal transducer activity IPR001019; IPR011025; IPR027417; IPR001932; IPR000222; IPR015655; Protein spalten [Includes: Probable guanine nucleotide-binding protein spalten; Protein serine/threonine phosphatase spalten (EC 3.1.3.16)] spnA spn DDB_G0276155 Dictyostelium discoideum (Slime mold) TR24312_c6_g1_i2 Q8RXV3 P2C59_ARATH 2.00E-16 GO:0042742; GO:0044419; GO:0046872; GO:0005886; GO:0006470; GO:0004722 defense response to bacterium; interspecies interaction between organisms; metal ion binding; plasma membrane; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; Probable protein phosphatase 2C 59 (AtPP2C59) (EC 3.1.3.16) (HopW1-1-interacting protein 2) (Protein phosphatase 2C WIN2) (PP2C WIN2) WIN2 At4g31750 F28M20.60 Arabidopsis thaliana (Mouse-ear cress) TR24312_c7_g1_i1 Q80TL0 PPM1E_MOUSE 4.00E-32 GO:0035690; GO:0005737; GO:0046872; GO:0006469; GO:0005730; GO:0035970; GO:0051496; GO:0043234; GO:0006470; GO:0004722 cellular response to drug; cytoplasm; metal ion binding; negative regulation of protein kinase activity; nucleolus; peptidyl-threonine dephosphorylation; positive regulation of stress fiber assembly; protein complex; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA) Ppm1e Camkn Kiaa1072 Mus musculus (Mouse) TR24320_c0_g1_i1 O75439 MPPB_HUMAN 1.00E-63 GO:0044267; GO:0046872; GO:0004222; GO:0005743; GO:0005759; GO:0006626; GO:0006508 cellular protein metabolic process; metal ion binding; metalloendopeptidase activity; mitochondrial inner membrane; mitochondrial matrix; protein targeting to mitochondrion; proteolysis IPR011249; IPR011237; IPR011765; IPR001431; IPR007863; Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) (P-52) PMPCB MPPB Homo sapiens (Human) TR24320_c3_g1_i1 P07256 QCR1_YEAST 6.00E-09 GO:0009060; GO:0003824; GO:0046872; GO:0005750 P07257 aerobic respiration; catalytic activity; metal ion binding; mitochondrial respiratory chain complex III IPR011249; IPR011237; IPR011765; IPR007863; "Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1)" COR1 QCR1 YBL045C YBL0403 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR24321_c0_g1_i1 P17713 STK_HYDVU 4.00E-74 GO:0005524; GO:0004715; GO:0018108 ATP binding; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK) STK Hydra vulgaris (Hydra) (Hydra attenuata) TR24322_c0_g1_i1 A5PKG7 KCTD5_BOVIN 2.00E-98 GO:0005829; GO:0051260 cytosol; protein homooligomerization IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein KCTD5 KCTD5 Bos taurus (Bovine) TR24323_c0_g1_i1 P46023 GR101_LYMST 4.00E-14 GO:0016021; GO:0005886; GO:0016500 integral to membrane; plasma membrane; protein-hormone receptor activity IPR000276; IPR017452; IPR002131; IPR023415; IPR002172; IPR001611; IPR003591; IPR000372; G-protein coupled receptor GRL101 Lymnaea stagnalis (Great pond snail) TR24324_c2_g1_i1 Q7TPV2 DZIP3_MOUSE 7.00E-08 GO:0003723; GO:0005737; GO:0016874; GO:0019902; GO:0016567; GO:0008270 RNA binding; cytoplasm; ligase activity; phosphatase binding; protein ubiquitination; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog) Dzip3 Kiaa0675 Mus musculus (Mouse) TR24325_c1_g1_i1 Q13255 GRM1_HUMAN 6.00E-07 GO:0004930; GO:0038038; GO:0000187; GO:0000186; GO:0008219; GO:0071257; GO:0030425; GO:0008066; GO:0005887; GO:0007626; GO:0005634; GO:0014069; GO:0051930; GO:0019233; GO:0007268 P52294 G-protein coupled receptor activity; G-protein coupled receptor homodimeric complex; activation of MAPK activity; activation of MAPKK activity; cell death; cellular response to electrical stimulus; dendrite; glutamate receptor activity; integral to plasma membrane; locomotory behavior; nucleus; postsynaptic density; regulation of sensory perception of pain; sensory perception of pain; synaptic transmission IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR000162; IPR001256; IPR019588; IPR028082; Metabotropic glutamate receptor 1 (mGluR1) GRM1 GPRC1A MGLUR1 Homo sapiens (Human) TR24326_c2_g1_i1 Q13415 ORC1_HUMAN 4.00E-33 GO:0005524; GO:0003677; GO:0006270; GO:0005829; GO:0005664; GO:0005730; GO:0005654; GO:0017111; GO:0005886; GO:0000083 P03211; Q13416; Q9UBD5; O43913; Q13309; Q15554 ATP binding; DNA binding; DNA replication initiation; cytosol; nuclear origin of replication recognition complex; nucleolus; nucleoplasm; nucleoside-triphosphatase activity; plasma membrane; regulation of transcription involved in G1/S transition of mitotic cell cycle IPR003593; IPR003959; IPR001025; IPR015163; IPR020793; IPR027417; IPR011991; Origin recognition complex subunit 1 (Replication control protein 1) ORC1 ORC1L PARC1 Homo sapiens (Human) TR24326_c3_g1_i1 O16810 ORC1_DROME 1.00E-30 GO:0005524; GO:0006277; GO:0003677; GO:0006270; GO:0008283; GO:0022008; GO:0005664; GO:0017111 ATP binding; DNA amplification; DNA binding; DNA replication initiation; cell proliferation; neurogenesis; nuclear origin of replication recognition complex; nucleoside-triphosphatase activity IPR003593; IPR003959; IPR001025; IPR015163; IPR020793; IPR027417; Origin recognition complex subunit 1 (DmORC1) Orc1 CG10667 Drosophila melanogaster (Fruit fly) TR24327_c2_g1_i1 Q90953 CSPG2_CHICK 2.00E-12 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Gallus gallus (Chicken) TR24328_c0_g1_i1 Q2Y0W8 S4A8_HUMAN 6.00E-90 GO:0015701; GO:0005452; GO:0016021; GO:0005886; GO:0006814; GO:0055085 bicarbonate transport; inorganic anion exchanger activity; integral to membrane; plasma membrane; sodium ion transport; transmembrane transport IPR013769; IPR011531; IPR003020; IPR003024; IPR016152; Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na(+)-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3) SLC4A8 KIAA0739 NBC NBC3 NDCBE1 Homo sapiens (Human) TR24337_c3_g1_i1 Q13315 ATM_HUMAN 1.00E-45 GO:0016303; GO:0005524; GO:0003677; GO:0006975; GO:0006977; GO:0004677; GO:0031572; GO:0007420; GO:0007050; GO:0071480; GO:0016023; GO:0000724; GO:0007292; GO:0007507; GO:0071044; GO:0035174; GO:0008630; GO:0042159; GO:0007094; GO:0030889; GO:0043066; GO:0051402; GO:0005654; GO:0018105; GO:0043517; GO:0043065; GO:0043525; GO:0002331; GO:0047485; GO:0046777; GO:0032403; GO:0046983; GO:0007131; GO:0090399; GO:0001666; GO:0001756; GO:0005819 Q9NY61; O43313; Q9Y6K9; Q14676; Q9BQ15; Q9Y4R8; P54274; P54274-2; O43156 "1-phosphatidylinositol-3-kinase activity; ATP binding; DNA binding; DNA damage induced protein phosphorylation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA-dependent protein kinase activity; G2 DNA damage checkpoint; brain development; cell cycle arrest; cellular response to gamma radiation; cytoplasmic membrane-bounded vesicle; double-strand break repair via homologous recombination; female gamete generation; heart development; histone mRNA catabolic process; histone serine kinase activity; intrinsic apoptotic signaling pathway in response to DNA damage; lipoprotein catabolic process; mitotic spindle assembly checkpoint; negative regulation of B cell proliferation; negative regulation of apoptotic process; neuron apoptotic process; nucleoplasm; peptidyl-serine phosphorylation; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of apoptotic process; positive regulation of neuron apoptotic process; pre-B cell allelic exclusion; protein N-terminus binding; protein autophosphorylation; protein complex binding; protein dimerization activity; reciprocal meiotic recombination; replicative senescence; response to hypoxia; somitogenesis; spindle" IPR016024; IPR003152; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR021668; Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) ATM Homo sapiens (Human) TR24337_c5_g1_i1 P38110 ATM_YEAST 1.00E-31 GO:0005524; GO:0000077; GO:0006975; GO:0000781; GO:0006302; GO:0016572; GO:0005634; GO:0004672; GO:0004674; GO:0090399; GO:0010212; GO:0000723; GO:0042162 "ATP binding; DNA damage checkpoint; DNA damage induced protein phosphorylation; chromosome, telomeric region; double-strand break repair; histone phosphorylation; nucleus; protein kinase activity; protein serine/threonine kinase activity; replicative senescence; response to ionizing radiation; telomere maintenance; telomeric DNA binding" IPR015519; IPR003152; IPR011009; IPR000403; IPR018936; IPR014009; IPR021668; Serine/threonine-protein kinase TEL1 (EC 2.7.11.1) (ATM homolog) (DNA-damage checkpoint kinase TEL1) (Telomere length regulation protein 1) TEL1 YBL088C YBL0706 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR24341_c0_g2_i1 P0DJ25 RL40_TETTS 2.00E-25 GO:0005634; GO:0005840; GO:0003735; GO:0006412 nucleus; ribosome; structural constituent of ribosome; translation IPR001975; IPR011332; IPR019956; IPR019954; IPR000626; Ubiquitin-60S ribosomal protein L40 [Cleaved into: Ubiquitin; 60S ribosomal protein L40] RPL40 Tetrahymena thermophila (strain SB210) TR24341_c0_g2_i2 P0DJ25 RL40_TETTS 4.00E-26 GO:0005634; GO:0005840; GO:0003735; GO:0006412 nucleus; ribosome; structural constituent of ribosome; translation IPR001975; IPR011332; IPR019956; IPR019954; IPR000626; Ubiquitin-60S ribosomal protein L40 [Cleaved into: Ubiquitin; 60S ribosomal protein L40] RPL40 Tetrahymena thermophila (strain SB210) TR24341_c4_g1_i1 Q54MG4 Y5975_DICDI 2.00E-21 GO:0016020; GO:0016192 membrane; vesicle-mediated transport IPR010989; IPR000727; IPR013694; IPR002035; von Willebrand factor A domain-containing protein DDB_G0285975 DDB_G0285975 Dictyostelium discoideum (Slime mold) TR24342_c0_g1_i1 Q19338 MON2_CAEEL 3.00E-09 GO:0005086; GO:0005794; GO:0015031; GO:0005802; GO:0016192 ARF guanyl-nucleotide exchange factor activity; Golgi apparatus; protein transport; trans-Golgi network; vesicle-mediated transport IPR016024; IPR026829; Monensin-resistant homolog 2 mon-2 F11A10.4 Caenorhabditis elegans TR24342_c1_g1_i1 Q9VLT1 MON2_DROME 6.00E-58 GO:0005086; GO:0005794; GO:0031532; GO:0005768; GO:0007318; GO:0015031; GO:0005802; GO:0016192 ARF guanyl-nucleotide exchange factor activity; Golgi apparatus; actin cytoskeleton reorganization; endosome; pole plasm protein localization; protein transport; trans-Golgi network; vesicle-mediated transport IPR016024; IPR015403; IPR026829; Protein MON2 homolog mon2 CG8683 Drosophila melanogaster (Fruit fly) TR24347_c1_g1_i1 A6QQL5 CB073_BOVIN 3.00E-06 Uncharacterized protein C2orf73 homolog Bos taurus (Bovine) TR24349_c0_g1_i1 O88470 FOXL2_MOUSE 2.00E-51 GO:0008301; GO:0003705; GO:0006309; GO:0043028; GO:0003690; GO:0048048; GO:0002074; GO:0019101; GO:0060014; GO:0042703; GO:0000122; GO:0005634; GO:0001541; GO:0007389; GO:0043065; GO:0043280; GO:0045944; GO:0051090; GO:0043565; GO:0008134; GO:0005667; GO:0031624 "DNA binding, bending; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; apoptotic DNA fragmentation; cysteine-type endopeptidase regulator activity involved in apoptotic process; double-stranded DNA binding; embryonic eye morphogenesis; extraocular skeletal muscle development; female somatic sex determination; granulosa cell differentiation; menstruation; negative regulation of transcription from RNA polymerase II promoter; nucleus; ovarian follicle development; pattern specification process; positive regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of transcription from RNA polymerase II promoter; regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; transcription factor binding; transcription factor complex; ubiquitin conjugating enzyme binding" IPR001766; IPR018122; IPR011991; Forkhead box protein L2 (Pituitary forkhead factor) (P-Frk) Foxl2 Pfrk Mus musculus (Mouse) TR24350_c1_g1_i1 Q76I89 NDC80_CHICK 8.00E-21 GO:0031262; GO:0008608; GO:0051301; GO:0007059; GO:0000777; GO:0000942; GO:0005737; GO:0000132; GO:0005815; GO:0007067; GO:0007052 Q90ZF9; Q76I90 Ndc80 complex; attachment of spindle microtubules to kinetochore; cell division; chromosome segregation; condensed chromosome kinetochore; condensed nuclear chromosome outer kinetochore; cytoplasm; establishment of mitotic spindle orientation; microtubule organizing center; mitosis; mitotic spindle organization IPR005550; Kinetochore protein NDC80 homolog (Kinetochore protein Hec1) (Kinetochore-associated protein 2) NDC80 HEC1 KNTC2 RCJMB04_4o15 Gallus gallus (Chicken) TR24355_c5_g1_i1 Q9VCX1 RGS_DROME 2.00E-06 GO:0007186; GO:0005092; GO:0005096; GO:0045179; GO:0016324; GO:0055059; GO:0008105; GO:0032291; GO:0007049; GO:0030866; GO:0007303; GO:0050832; GO:0008069; GO:0000578; GO:0014045; GO:0060857; GO:0003015; GO:0007310; GO:0005886; GO:0005057; GO:0008277; GO:0009786; GO:0009408; GO:0006979; GO:0042594; GO:0019991; GO:0038032; GO:0007419 "G-protein coupled receptor signaling pathway; GDP-dissociation inhibitor activity; GTPase activator activity; apical cortex; apical plasma membrane; asymmetric neuroblast division; asymmetric protein localization; axon ensheathment in central nervous system; cell cycle; cortical actin cytoskeleton organization; cytoplasmic transport, nurse cell to oocyte; defense response to fungus; dorsal/ventral axis specification, ovarian follicular epithelium; embryonic axis specification; establishment of endothelial blood-brain barrier; establishment of glial blood-brain barrier; heart process; oocyte dorsal/ventral axis specification; plasma membrane; receptor signaling protein activity; regulation of G-protein coupled receptor protein signaling pathway; regulation of asymmetric cell division; response to heat; response to oxidative stress; response to starvation; septate junction assembly; termination of G-protein coupled receptor signaling pathway; ventral cord development" IPR003109; IPR001478; IPR011993; IPR006020; IPR003116; IPR024066; IPR016137; IPR000342; Regulator of G-protein signaling loco (RGS) (Locomotion defects protein) (Loco) loco CG5248 Drosophila melanogaster (Fruit fly) TR24355_c8_g1_i1 Q32PP1 CE045_DANRE 9.00E-25 UPF0544 protein C5orf45 homolog zgc:123335 Danio rerio (Zebrafish) (Brachydanio rerio) TR24360_c0_g2_i1 Q5ZME2 MDHC_CHICK 3.00E-81 GO:0030060; GO:0044262; GO:0005737; GO:0006094; GO:0006108; GO:0044281; GO:0006099 L-malate dehydrogenase activity; cellular carbohydrate metabolic process; cytoplasm; gluconeogenesis; malate metabolic process; small molecule metabolic process; tricarboxylic acid cycle IPR001557; IPR022383; IPR001236; IPR015955; IPR001252; IPR011274; IPR010945; IPR016040; "Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Cytosolic malate dehydrogenase)" MDH1 RCJMB04_2g5 Gallus gallus (Chicken) TR24363_c0_g1_i2 P82003 PTSP_BOMMO 4.00E-09 GO:0005615; GO:0002168 extracellular space; instar larval development Prothoracicostatic peptide (Bom-PTSP) Bombyx mori (Silk moth) TR24364_c1_g1_i1 P16610 NK2R_RAT 2.00E-08 GO:0016021; GO:0014827; GO:0016020; GO:0033685; GO:0035106; GO:0005886; GO:0014057; GO:0070474; GO:0043117; GO:0070459; GO:0016497 "integral to membrane; intestine smooth muscle contraction; membrane; negative regulation of luteinizing hormone secretion; operant conditioning; plasma membrane; positive regulation of acetylcholine secretion, neurotransmission; positive regulation of uterine smooth muscle contraction; positive regulation of vascular permeability; prolactin secretion; substance K receptor activity" IPR000276; IPR017452; IPR001681; IPR000913; Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2) Tacr2 Tac2r Rattus norvegicus (Rat) TR24364_c2_g1_i1 P70031 CCKAR_XENLA 4.00E-50 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR009126; IPR000276; IPR017452; Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) TR24365_c0_g1_i1 P35561 IRK2_MOUSE 1.00E-62 GO:0030425; GO:0016021; GO:0031224; GO:0005242; GO:0015693; GO:0043025; GO:0051289; GO:0086001 Itself; P24588; B2RYN6; Q15700-4; Q2YHQ3 dendrite; integral to membrane; intrinsic to membrane; inward rectifier potassium channel activity; magnesium ion transport; neuronal cell body; protein homotetramerization; regulation of cardiac muscle cell action potential IPR014756; IPR016449; IPR003271; IPR013518; IPR013673; "Inward rectifier potassium channel 2 (Inward rectifier K(+) channel Kir2.1) (IRK-1) (Potassium channel, inwardly rectifying subfamily J member 2)" Kcnj2 Irk1 Mus musculus (Mouse) TR24368_c0_g1_i1 Q3ZBW4 PCNA_BOVIN 7.00E-136 GO:0030337; GO:0006260; GO:0043626; GO:0070557; GO:0005737; GO:0032139; GO:0015630; GO:0006298; GO:0043596; GO:0032077; GO:0000701; GO:0006275; GO:0019985 DNA polymerase processivity factor activity; DNA replication; PCNA complex; PCNA-p21 complex; cytoplasm; dinucleotide insertion or deletion binding; microtubule cytoskeleton; mismatch repair; nuclear replication fork; positive regulation of deoxyribonuclease activity; purine-specific mismatch base pair DNA N-glycosylase activity; regulation of DNA replication; translesion synthesis IPR000730; IPR022649; IPR022659; IPR022648; Proliferating cell nuclear antigen (PCNA) PCNA Bos taurus (Bovine) TR24368_c0_g1_i2 Q3ZBW4 PCNA_BOVIN 2.00E-143 GO:0030337; GO:0006260; GO:0043626; GO:0070557; GO:0005737; GO:0032139; GO:0015630; GO:0006298; GO:0043596; GO:0032077; GO:0000701; GO:0006275; GO:0019985 DNA polymerase processivity factor activity; DNA replication; PCNA complex; PCNA-p21 complex; cytoplasm; dinucleotide insertion or deletion binding; microtubule cytoskeleton; mismatch repair; nuclear replication fork; positive regulation of deoxyribonuclease activity; purine-specific mismatch base pair DNA N-glycosylase activity; regulation of DNA replication; translesion synthesis IPR000730; IPR022649; IPR022659; IPR022648; Proliferating cell nuclear antigen (PCNA) PCNA Bos taurus (Bovine) TR24373_c3_g1_i1 O13134 S4A4_AMBTI 2.00E-19 GO:0016323; GO:0005452; GO:0016021; GO:0006814; GO:0015293 basolateral plasma membrane; inorganic anion exchanger activity; integral to membrane; sodium ion transport; symporter activity IPR013769; IPR011531; IPR003020; IPR003024; IPR016152; Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) SLC4A4 NBC NBCE1 Ambystoma tigrinum (Eastern tiger salamander) TR24373_c4_g1_i1 Q9R1N3 S4A7_RAT 1.00E-27 GO:0016324; GO:0016323; GO:0031410; GO:0005452; GO:0016021; GO:0006814; GO:0032420; GO:0015293 apical plasma membrane; basolateral plasma membrane; cytoplasmic vesicle; inorganic anion exchanger activity; integral to membrane; sodium ion transport; stereocilium; symporter activity IPR013769; IPR011531; IPR003020; IPR016152; Sodium bicarbonate cotransporter 3 (Electroneutral sodium bicarbonate cotransporter 1) (NBC-like protein) (Solute carrier family 4 member 7) Slc4a7 Nbc Nbc2 Nbc3 Nbcn1 Rattus norvegicus (Rat) TR24376_c0_g1_i1 Q3ZBK1 WDR89_BOVIN 5.00E-52 IPR015943; IPR001680; IPR017986; WD repeat-containing protein 89 WDR89 Bos taurus (Bovine) TR2438_c0_g1_i1 P0A962 ASPG1_ECOLI 5.00E-26 GO:0004067; GO:0033345; GO:0005737; GO:0042802 asparaginase activity; asparagine catabolic process via L-aspartate; cytoplasm; identical protein binding IPR006033; IPR006034; IPR020827; IPR027475; IPR027473; IPR027474; L-asparaginase 1 (EC 3.5.1.1) (L-asparaginase I) (L-ASNase I) (L-asparagine amidohydrolase I) ansA b1767 JW1756 Escherichia coli (strain K12) TR24380_c0_g1_i1 Q5R4W3 DPOE3_PONAB 3.00E-51 GO:0005671; GO:0003887; GO:0008622; GO:0043966; GO:0043565 Ada2/Gcn5/Ada3 transcription activator complex; DNA-directed DNA polymerase activity; epsilon DNA polymerase complex; histone H3 acetylation; sequence-specific DNA binding IPR003958; IPR009072; DNA polymerase epsilon subunit 3 (EC 2.7.7.7) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) POLE3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR24380_c0_g2_i1 P25211 NFYB_XENLA 7.00E-07 GO:0005634; GO:0006355; GO:0043565; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription, DNA-dependent" IPR003958; IPR009072; IPR003957; IPR003956; Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB) (Fragment) nfyb Xenopus laevis (African clawed frog) TR24384_c0_g3_i2 A4IGY6 S39AE_XENTR 1.00E-69 GO:0016021; GO:0046873; GO:0005886; GO:0071577 integral to membrane; metal ion transmembrane transporter activity; plasma membrane; zinc ion transmembrane transport IPR003689; Zinc transporter ZIP14 (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14) slc39a14 zip14 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR24389_c0_g1_i1 Q969H0 FBXW7_HUMAN 1.00E-48 GO:0005794; GO:0007219; GO:0019005; GO:0031146; GO:0034644; GO:0005783; GO:0055088; GO:0030324; GO:0019048; GO:0032876; GO:0045746; GO:2000639; GO:2000346; GO:0010868; GO:0005730; GO:0005654; GO:0070374; GO:0045741; GO:2000060; GO:0043234; GO:0050821; GO:0016567; GO:0010883; GO:0032880; GO:0006974; GO:0003700; GO:0007062; GO:0001944; GO:0001570 Q16204; P24941; P01106; P63208; Q9UBI4 Golgi apparatus; Notch signaling pathway; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cellular response to UV; endoplasmic reticulum; lipid homeostasis; lung development; modulation by virus of host morphology or physiology; negative regulation of DNA endoreduplication; negative regulation of Notch signaling pathway; negative regulation of SREBP signaling pathway; negative regulation of hepatocyte proliferation; negative regulation of triglyceride biosynthetic process; nucleolus; nucleoplasm; positive regulation of ERK1 and ERK2 cascade; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein complex; protein stabilization; protein ubiquitination; regulation of lipid storage; regulation of protein localization; response to DNA damage stimulus; sequence-specific DNA binding transcription factor activity; sister chromatid cohesion; vasculature development; vasculogenesis IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4) FBXW7 FBW7 FBX30 SEL10 Homo sapiens (Human) TR24389_c0_g2_i1 Q2TBP4 POC1A_BOVIN 6.00E-15 GO:0030030; GO:0005814; GO:0005932 cell projection organization; centriole; microtubule basal body IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; POC1 centriolar protein homolog A (WD repeat-containing protein 51A) POC1A WDR51A Bos taurus (Bovine) TR24389_c3_g1_i1 Q01277 SCONB_NEUCR 4.00E-16 GO:0016567; GO:0006355; GO:0006351 "protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001810; IPR020472; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. Probable E3 ubiquitin ligase complex SCF subunit scon-2 (Sulfur controller 2) (SCON2) (Sulfur metabolite repression control protein 2) scon-2 B13M15.090 NCU08563 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR24389_c4_g1_i1 Q8IX29 FBX16_HUMAN 1.00E-12 IPR001810; F-box only protein 16 FBXO16 FBX16 Homo sapiens (Human) TR24391_c0_g1_i1 A6NHM9 MOXD2_HUMAN 4.00E-12 GO:0006584; GO:0005507; GO:0004500 catecholamine metabolic process; copper ion binding; dopamine beta-monooxygenase activity IPR014784; IPR000323; IPR000945; IPR005018; IPR008977; Putative DBH-like monooxygenase protein 2 (EC 1.14.17.-) (DBH-like monooxygenase protein 2 pseudogene) MOXD2P MOXD2 Homo sapiens (Human) TR24391_c1_g1_i1 Q9XTQ6 TBH1_CAEEL 2.00E-21 GO:0006584; GO:0030054; GO:0005507; GO:0004500; GO:0042136; GO:0045202; GO:0008021 catecholamine metabolic process; cell junction; copper ion binding; dopamine beta-monooxygenase activity; neurotransmitter biosynthetic process; synapse; synaptic vesicle IPR014784; IPR020611; IPR000323; IPR000945; IPR005018; IPR008977; Tyramine beta-hydroxylase (EC 1.14.17.-) tbh-1 H13N06.6 Caenorhabditis elegans TR24393_c1_g1_i1 P19984 PROF2_ACACA 3.00E-10 GO:0030036; GO:0005737; GO:0005856 actin cytoskeleton organization; cytoplasm; cytoskeleton IPR027310; IPR005455; Profilin-2 (Basic profilin) (Profilin II) Acanthamoeba castellanii (Amoeba) TR24403_c1_g1_i1 Q460N5 PAR14_HUMAN 2.00E-29 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR24410_c0_g1_i1 A2ASS6 TITIN_MOUSE 3.00E-10 GO:0005524; GO:0031430; GO:0030018; GO:0007512; GO:0055003; GO:0043056; GO:0003007; GO:0001701; GO:0046872; GO:0006936; GO:0005859; GO:0005634; GO:0018108; GO:0004674; GO:0004713; GO:1901897; GO:0045214; GO:0001756; GO:0005200 ATP binding; M band; Z disc; adult heart development; cardiac myofibril assembly; forward locomotion; heart morphogenesis; in utero embryonic development; metal ion binding; muscle contraction; muscle myosin complex; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of relaxation of cardiac muscle; sarcomere organization; somitogenesis; structural constituent of cytoskeleton IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) TR24412_c1_g1_i1 P28039 AOAH_HUMAN 2.00E-36 GO:0050528; GO:0005576; GO:0006954; GO:0006629; GO:0008653; GO:0004465; GO:0050728 acyloxyacyl hydrolase activity; extracellular region; inflammatory response; lipid metabolic process; lipopolysaccharide metabolic process; lipoprotein lipase activity; negative regulation of inflammatory response IPR001087; IPR008138; IPR011001; IPR008139; IPR013831; Acyloxyacyl hydrolase (EC 3.1.1.77) [Cleaved into: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit] AOAH Homo sapiens (Human) TR24413_c0_g1_i1 Q02369 NDUB9_BOVIN 4.00E-26 GO:0005747; GO:0055114 mitochondrial respiratory chain complex I; oxidation-reduction process IPR008011; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (Complex I-B22) (CI-B22) (NADH-ubiquinone oxidoreductase B22 subunit) NDUFB9 UQOR22 Bos taurus (Bovine) TR24415_c1_g1_i1 O60308 CE104_HUMAN 5.00E-36 GO:0005814 centriole IPR011989; IPR016024; IPR008979; Centrosomal protein of 104 kDa (Cep104) CEP104 KIAA0562 Homo sapiens (Human) TR24419_c0_g1_i1 Q98902 L1CAM_TAKRU 2.00E-07 GO:0007155; GO:0016021; GO:0005886 cell adhesion; integral to membrane; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR026966; Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (L1-CAM) l1cam Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR24423_c0_g1_i1 Q9Y4E6 WDR7_HUMAN 5.00E-60 IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 7 (Rabconnectin-3 beta) (TGF-beta resistance-associated protein TRAG) WDR7 KIAA0541 TRAG Homo sapiens (Human) TR24426_c0_g1_i1 P10079 FBP1_STRPU 2.00E-10 GO:0032579; GO:0005509; GO:0016023; GO:0005615 apical lamina of hyaline layer; calcium ion binding; cytoplasmic membrane-bounded vesicle; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) TR24431_c0_g1_i1 Q96MM6 HS12B_HUMAN 6.00E-10 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR24434_c0_g1_i1 Q8BXB6 SO2B1_MOUSE 1.00E-70 GO:0016021; GO:0006811; GO:0005886; GO:0005215 integral to membrane; ion transport; plasma membrane; transporter activity IPR002350; IPR016196; IPR004156; Solute carrier organic anion transporter family member 2B1 (Solute carrier family 21 member 9) Slco2b1 Oatp2b1 Slc21a9 Mus musculus (Mouse) TR24436_c0_g2_i1 P62972 UBIQP_XENLA 1.00E-50 GO:0005737; GO:0005634 Q9NPC3 cytoplasm; nucleus IPR019956; IPR019954; IPR000626; Polyubiquitin [Cleaved into: Ubiquitin] (Fragment) Xenopus laevis (African clawed frog) TR24437_c0_g1_i1 Q9VGG5 CAD87_DROME 6.00E-50 GO:0005509; GO:0016339; GO:0007156; GO:0005887 calcium ion binding; calcium-dependent cell-cell adhesion; homophilic cell adhesion; integral to plasma membrane IPR002126; IPR015919; IPR020894; Cadherin-87A Cad87A CG6977 Drosophila melanogaster (Fruit fly) TR24437_c0_g1_i2 O35161 CELR1_MOUSE 3.00E-32 GO:0004930; GO:0007266; GO:0009952; GO:0045176; GO:0005509; GO:0007267; GO:0007417; GO:0048105; GO:0042249; GO:0001702; GO:0001942; GO:0007156; GO:0042472; GO:0005887; GO:0060490; GO:0007626; GO:0001843; GO:0001764; GO:0007218; GO:0060488; GO:0090179; GO:0060489; GO:0046983; GO:0090251; GO:0032956; GO:0046928; GO:0042060 Q7T0S3 G-protein coupled receptor activity; Rho protein signal transduction; anterior/posterior pattern specification; apical protein localization; calcium ion binding; cell-cell signaling; central nervous system development; establishment of body hair planar orientation; establishment of planar polarity of embryonic epithelium; gastrulation with mouth forming second; hair follicle development; homophilic cell adhesion; inner ear morphogenesis; integral to plasma membrane; lateral sprouting involved in lung morphogenesis; locomotory behavior; neural tube closure; neuron migration; neuropeptide signaling pathway; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis; planar cell polarity pathway involved in neural tube closure; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis; protein dimerization activity; protein localization involved in establishment of planar polarity; regulation of actin cytoskeleton organization; regulation of neurotransmitter secretion; wound healing IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR013032; IPR000152; IPR002049; IPR017981; IPR001879; IPR000832; IPR000203; IPR009030; IPR001791; Cadherin EGF LAG seven-pass G-type receptor 1 Celsr1 Mus musculus (Mouse) TR24437_c2_g1_i1 Q8IXH8 CAD26_HUMAN 1.00E-07 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; Cadherin-like protein 26 (Cadherin-like protein VR20) CDH26 Homo sapiens (Human) TR24441_c0_g1_i1 Q01490 PPIB_ORPSP 1.00E-44 GO:0005788; GO:0042277; GO:0003755; GO:0006457; GO:0000413 endoplasmic reticulum lumen; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) CYPB Orpinomyces sp. (strain PC-2) TR24442_c0_g1_i1 Q0D2K0 NIPA4_HUMAN 3.00E-08 GO:0016021; GO:0015095 integral to membrane; magnesium ion transmembrane transporter activity IPR008521; Magnesium transporter NIPA4 (Ichthyin) (NIPA-like protein 4) (Non-imprinted in Prader-Willi/Angelman syndrome region protein 4) NIPAL4 ICHN NIPA4 Homo sapiens (Human) TR24443_c1_g2_i1 Q8WWB3 DYDC1_HUMAN 3.00E-10 IPR007858; DPY30 domain-containing protein 1 DYDC1 DPY30D1 RSD-9 RSD9 Homo sapiens (Human) TR24444_c0_g1_i2 Q5F416 TIPIN_CHICK 2.00E-40 GO:0000076; GO:0051301; GO:0005737; GO:0031573; GO:0007067; GO:0000790; GO:0008284; GO:0048478 DNA replication checkpoint; cell division; cytoplasm; intra-S DNA damage checkpoint; mitosis; nuclear chromatin; positive regulation of cell proliferation; replication fork protection IPR012923; TIMELESS-interacting protein TIPIN RCJMB04_3n6 Gallus gallus (Chicken) TR24446_c0_g1_i1 Q6GMV3 PTRD1_HUMAN 7.00E-32 GO:0004045; GO:0035335; GO:0004725 aminoacyl-tRNA hydrolase activity; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR023476; IPR002833; IPR017867; Putative peptidyl-tRNA hydrolase PTRHD1 (EC 3.1.1.29) (Peptidyl-tRNA hydrolase domain-containing protein 1) PTRHD1 C2orf79 Homo sapiens (Human) TR24448_c0_g1_i1 O14562 UBFD1_HUMAN 4.00E-93 IPR019954; IPR000626; Ubiquitin domain-containing protein UBFD1 (Ubiquitin-binding protein homolog) UBFD1 UBPH Homo sapiens (Human) TR24450_c0_g1_i2 P27952 RS2_RAT 4.00E-135 GO:0003723; GO:0022627; GO:0001731; GO:0032403; GO:0000028; GO:0003735 RNA binding; cytosolic small ribosomal subunit; formation of translation preinitiation complex; protein complex binding; ribosomal small subunit assembly; structural constituent of ribosome IPR014720; IPR000851; IPR005324; IPR020568; IPR014721; IPR005711; IPR013810; IPR018192; 40S ribosomal protein S2 Rps2 Rattus norvegicus (Rat) TR24456_c1_g1_i2 Q6PG95 CRML_MOUSE 8.00E-25 GO:0003677; GO:0003682; GO:0005634 DNA binding; chromatin binding; nucleus IPR001005; IPR017884; Protein cramped-like (Hematological and neurological expressed 1-like protein) Cramp1l Hn1l Kiaa1426 Tce4 Mus musculus (Mouse) TR24458_c1_g1_i1 H2A0N9 KCP4_PINMG 1.00E-12 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR004094; IPR011061; IPR002223; IPR020901; BPTI/Kunitz domain-containing protein 4 (Nacre serine protease inhibitor 3) (NSPI3) Pinctada margaritifera (Black-lipped pearl oyster) TR24458_c3_g1_i1 P38977 ANTA_HYDVU 4.00E-20 GO:0007596; GO:0005576; GO:0008201; GO:0004867 blood coagulation; extracellular region; heparin binding; serine-type endopeptidase inhibitor activity IPR004094; IPR011061; Antistasin (ATS) (Blood coagulation factor Xa/proclotting enzyme inhibitor) Hydra vulgaris (Hydra) (Hydra attenuata) TR24459_c0_g3_i1 Q19673 TYR3_CAEEL 1.00E-12 GO:0046872; GO:0004497 metal ion binding; monooxygenase activity IPR003582; IPR002227; IPR008922; Putative tyrosinase-like protein tyr-3 tyr-3 F21C3.2 Caenorhabditis elegans TR24460_c0_g1_i1 Q8C172 CERS6_MOUSE 3.00E-06 GO:0046513; GO:0005783; GO:0005789; GO:0016021; GO:0031965; GO:0043565; GO:0003700; GO:0050291 ceramide biosynthetic process; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nuclear membrane; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sphingosine N-acyltransferase activity IPR001356; IPR009057; IPR016439; IPR006634; Ceramide synthase 6 (CerS6) (LAG1 longevity assurance homolog 6) Cers6 Lass6 Mus musculus (Mouse) TR24460_c0_g1_i2 Q9D6J1 CERS4_MOUSE 1.00E-13 GO:0046513; GO:0005783; GO:0005789; GO:0016021; GO:0031965; GO:0043565; GO:0003700; GO:0050291 ceramide biosynthetic process; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nuclear membrane; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sphingosine N-acyltransferase activity IPR001356; IPR009057; IPR016439; IPR006634; Ceramide synthase 4 (CerS4) (LAG1 longevity assurance homolog 4) (Translocating chain-associating membrane protein homolog 1) (TRAM homolog 1) Cers4 Lass4 Trh1 Mus musculus (Mouse) TR24461_c1_g1_i1 Q01279 EGFR_MOUSE 2.00E-14 GO:0005524; GO:0000139; GO:0016323; GO:0000902; GO:0008283; GO:0016337; GO:0071392; GO:0021795; GO:0003682; GO:0048546; GO:0001892; GO:0030139; GO:0005789; GO:0005768; GO:0010008; GO:0005006; GO:0001942; GO:0016021; GO:0045121; GO:0060571; GO:0043066; GO:0042177; GO:0030235; GO:0031965; GO:0005634; GO:0048471; GO:0045739; GO:0045740; GO:0070374; GO:0043406; GO:0035413; GO:0030335; GO:0031659; GO:0050679; GO:0048146; GO:0045429; GO:0051897; GO:0001934; GO:0045944; GO:0046777; GO:0004716; GO:0050999; GO:0050730; GO:0070141; GO:0007435; GO:0023014 P01133; P32883 ATP binding; Golgi membrane; basolateral plasma membrane; cell morphogenesis; cell proliferation; cell-cell adhesion; cellular response to estradiol stimulus; cerebral cortex cell migration; chromatin binding; digestive tract morphogenesis; embryonic placenta development; endocytic vesicle; endoplasmic reticulum membrane; endosome; endosome membrane; epidermal growth factor-activated receptor activity; hair follicle development; integral to membrane; membrane raft; morphogenesis of an epithelial fold; negative regulation of apoptotic process; negative regulation of protein catabolic process; nitric-oxide synthase regulator activity; nuclear membrane; nucleus; perinuclear region of cytoplasm; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAP kinase activity; positive regulation of catenin import into nucleus; positive regulation of cell migration; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of nitric oxide biosynthetic process; positive regulation of protein kinase B signaling cascade; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein autophosphorylation; receptor signaling protein tyrosine kinase activity; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; response to UV-A; salivary gland morphogenesis; signal transduction by phosphorylation IPR000494; IPR006211; IPR006212; IPR009030; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR016245; Epidermal growth factor receptor (EC 2.7.10.1) Egfr Mus musculus (Mouse) TR24461_c1_g2_i1 P0CY46 EGFR_APIME 3.00E-24 GO:0005524; GO:0016021; GO:0007275; GO:0018108; GO:0004714; GO:0007169 ATP binding; integral to membrane; multicellular organismal development; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000494; IPR006211; IPR006212; IPR009030; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Epidermal growth factor receptor (Egfr) (EC 2.7.10.1) Egfr Apis mellifera (Honeybee) TR24464_c2_g1_i1 Q8C1B2 PARPT_MOUSE 5.00E-26 GO:0003950; GO:0008209; GO:0008210; GO:0060325; GO:0008585; GO:0030097; GO:0001822; GO:0046872; GO:0044236; GO:0006807; GO:0060021; GO:0048008; GO:0009791; GO:0006471; GO:0048705; GO:0048745; GO:0001570 NAD+ ADP-ribosyltransferase activity; androgen metabolic process; estrogen metabolic process; face morphogenesis; female gonad development; hemopoiesis; kidney development; metal ion binding; multicellular organismal metabolic process; nitrogen compound metabolic process; palate development; platelet-derived growth factor receptor signaling pathway; post-embryonic development; protein ADP-ribosylation; skeletal system morphogenesis; smooth muscle tissue development; vasculogenesis IPR012317; IPR004170; IPR000571; TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) Tiparp Mus musculus (Mouse) TR24465_c0_g1_i1 Q5ATH9 BXLB_EMENI 9.00E-20 GO:0046556; GO:0005576; GO:0009044; GO:0045493; GO:0042285 "alpha-N-arabinofuranosidase activity; extracellular region; xylan 1,4-beta-xylosidase activity; xylan catabolic process; xylosyltransferase activity" IPR026891; IPR026892; IPR002772; IPR001764; IPR017853; Glycan degradation; xylan degradation. "Exo-1,4-beta-xylosidase bxlB (EC 3.2.1.37) (1,4-beta-D-xylan xylohydrolase bxlB) (Beta-xylosidase bxlB) (Xylobiase bxlB)" bxlB AN8401 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR24466_c3_g2_i1 Q8WSR4 ITPR_ASTPE 0 GO:0005789; GO:0005220; GO:0048016; GO:0016021; GO:0007275; GO:0007338 "endoplasmic reticulum membrane; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; inositol phosphate-mediated signaling; integral to membrane; multicellular organismal development; single fertilization" IPR016024; IPR000699; IPR014821; IPR000493; IPR005821; IPR016093; IPR013662; IPR015925; "Inositol 1,4,5-trisphosphate receptor (ApIP3R)" IP3R Patiria pectinifera (Starfish) (Asterina pectinifera) TR24467_c0_g1_i3 Q9C0I4 THS7B_HUMAN 9.00E-06 GO:0016021 integral to membrane IPR000884; Thrombospondin type-1 domain-containing protein 7B THSD7B KIAA1679 Homo sapiens (Human) TR24468_c0_g1_i1 Q18785 MIF2_CAEEL 2.00E-16 IPR001398; IPR019829; IPR014347; MIF-like protein mif-2 mif-2 C52E4.2 Caenorhabditis elegans TR24479_c1_g1_i1 Q4WUV8 XKS1_ASPFU 2.00E-28 GO:0005524; GO:0042732; GO:0005737; GO:0004856 ATP binding; D-xylose metabolic process; cytoplasm; xylulokinase activity IPR018485; IPR018484; Probable D-xylulose kinase A (Xylulokinase A) (EC 2.7.1.17) xkiA AFUA_5G09840 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) TR24479_c3_g1_i1 Q3TNA1 XYLB_MOUSE 5.00E-66 GO:0005524; GO:0042732; GO:0004856; GO:0005997 ATP binding; D-xylose metabolic process; xylulokinase activity; xylulose metabolic process IPR018485; IPR018484; Xylulose kinase (Xylulokinase) (EC 2.7.1.17) Xylb Mus musculus (Mouse) TR24483_c1_g1_i1 Q04833 LRP_CAEEL 1.00E-06 GO:0016324; GO:0005509; GO:0005905; GO:0042395; GO:0030139; GO:0006897; GO:0016021; GO:0002119; GO:0040017; GO:0040018; GO:0030334; GO:0015248 "apical plasma membrane; calcium ion binding; coated pit; ecdysis, collagen and cuticulin-based cuticle; endocytic vesicle; endocytosis; integral to membrane; nematode larval development; positive regulation of locomotion; positive regulation of multicellular organism growth; regulation of cell migration; sterol transporter activity" IPR011042; IPR000742; IPR001881; IPR013032; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein (LRP) lrp-1 F29D11.1 Caenorhabditis elegans TR24483_c6_g1_i1 Q8NFP4 MDGA1_HUMAN 6.00E-06 GO:0046658; GO:0007420; GO:0001764; GO:0021527 anchored to plasma membrane; brain development; neuron migration; spinal cord association neuron differentiation IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3) MDGA1 MAMDC3 Homo sapiens (Human) TR24486_c1_g1_i1 Q9D687 S6A19_MOUSE 5.00E-15 GO:0005887; GO:0005328; GO:0015175; GO:0005886; GO:0007584 integral to plasma membrane; neurotransmitter:sodium symporter activity; neutral amino acid transmembrane transporter activity; plasma membrane; response to nutrient IPR000175; IPR002438; Sodium-dependent neutral amino acid transporter B(0)AT1 (Solute carrier family 6 member 19) (System B(0) neutral amino acid transporter AT1) Slc6a19 B0at1 Mus musculus (Mouse) TR24489_c1_g5_i1 Q14162 SREC_HUMAN 8.00E-15 GO:0007155; GO:0006707; GO:0016358; GO:0030666; GO:0016021; GO:0030169; GO:0016322; GO:0005886; GO:0048680; GO:0005044; GO:0004888 cell adhesion; cholesterol catabolic process; dendrite development; endocytic vesicle membrane; integral to membrane; low-density lipoprotein particle binding; neuron remodeling; plasma membrane; positive regulation of axon regeneration; scavenger receptor activity; transmembrane signaling receptor activity IPR000742; IPR013032; IPR002049; IPR009030; Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) TR24489_c1_g5_i2 Q06805 TIE1_BOVIN 3.00E-19 GO:0005524; GO:0001525; GO:0016021; GO:0018108; GO:0005886; GO:0004714 ATP binding; angiogenesis; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; transmembrane receptor protein tyrosine kinase activity IPR000742; IPR013032; IPR003961; IPR013783; IPR003599; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE TIE-1 Bos taurus (Bovine) TR24489_c1_g6_i1 Q54KF7 SIBA_DICDI 9.00E-07 GO:0005509; GO:0009986; GO:0031589; GO:0005769; GO:0016021; GO:0006909; GO:0005886; GO:0055037 P54633 calcium ion binding; cell surface; cell-substrate adhesion; early endosome; integral to membrane; phagocytosis; plasma membrane; recycling endosome IPR015919; IPR000742; IPR013032; IPR002035; Integrin beta-like protein A (109 gene 1 protein) sibA DDB_G0287363 Dictyostelium discoideum (Slime mold) TR24489_c1_g7_i5 Q96KG7 MEG10_HUMAN 1.00E-20 GO:0016323; GO:0042995; GO:0034109; GO:0016021; GO:0055001; GO:0001891; GO:0043654; GO:0051147; GO:0048641; GO:0014719; GO:0014816; GO:0014841 basolateral plasma membrane; cell projection; homotypic cell-cell adhesion; integral to membrane; muscle cell development; phagocytic cup; recognition of apoptotic cell; regulation of muscle cell differentiation; regulation of skeletal muscle tissue development; satellite cell activation; satellite cell differentiation; satellite cell proliferation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) TR24489_c1_g7_i7 Q96GP6 SREC2_HUMAN 1.00E-18 GO:0007157; GO:0016021; GO:0005044 P16333 heterophilic cell-cell adhesion; integral to membrane; scavenger receptor activity IPR000742; IPR013032; IPR002049; IPR009030; Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) TR24496_c2_g2_i1 Q9JHA8 VWA7_MOUSE 9.00E-21 GO:0005576 extracellular region IPR002035; von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 D17h6s56e-3 G7c Mus musculus (Mouse) TR24498_c2_g1_i1 Q17RM4 CC142_HUMAN 2.00E-09 IPR026700; Coiled-coil domain-containing protein 142 CCDC142 PSEC0243 Homo sapiens (Human) TR245_c0_g1_i1 Q7LBC6 KDM3B_HUMAN 3.00E-28 GO:0016568; GO:0051213; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "chromatin modification; dioxygenase activity; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003347; Lysine-specific demethylase 3B (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) KDM3B C5orf7 JHDM2B JMJD1B KIAA1082 Homo sapiens (Human) TR24502_c3_g1_i1 Q02989 LITA_LATTR 2.00E-09 GO:0006887; GO:0016021; GO:0072556 exocytosis; integral to membrane; other organism presynaptic membrane IPR002110; IPR020683; IPR028047; Alpha-latroinsectotoxin-Lt1a (Alpha-LIT-Lt1a) (Alpha-latroinsectotoxin) (Alpha-LIT) (Fragment) Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus) TR24512_c1_g1_i1 Q5YCC5 TMC7_CHICK 2.00E-49 GO:0016021; GO:0006811 integral to membrane; ion transport IPR012496; Transmembrane channel-like protein 7 Tmc7 Gallus gallus (Chicken) TR24512_c1_g2_i1 Q6UXY8 TMC5_HUMAN 4.00E-30 GO:0016021; GO:0006811 integral to membrane; ion transport IPR012496; Transmembrane channel-like protein 5 TMC5 UNQ8238/PRO33604 Homo sapiens (Human) TR24515_c0_g1_i1 Q91WN4 KMO_MOUSE 2.00E-28 GO:0009435; GO:0019674; GO:0016174; GO:0050660; GO:0016021; GO:0004502; GO:0005743; GO:0005741; GO:0019805; GO:0009651; GO:0019441 NAD biosynthetic process; NAD metabolic process; NAD(P)H oxidase activity; flavin adenine dinucleotide binding; integral to membrane; kynurenine 3-monooxygenase activity; mitochondrial inner membrane; mitochondrial outer membrane; quinolinate biosynthetic process; response to salt stress; tryptophan catabolic process to kynurenine IPR027545; IPR002938; IPR003042; Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3. Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase) Kmo Mus musculus (Mouse) TR24515_c0_g2_i1 Q1RLY6 KMO_DANRE 6.00E-28 GO:0009435; GO:0019674; GO:0016021; GO:0004502; GO:0005741; GO:0019805; GO:0006569 NAD biosynthetic process; NAD metabolic process; integral to membrane; kynurenine 3-monooxygenase activity; mitochondrial outer membrane; quinolinate biosynthetic process; tryptophan catabolic process IPR027545; IPR002938; IPR003042; Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3. Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase) kmo zgc:136684 Danio rerio (Zebrafish) (Brachydanio rerio) TR24518_c0_g2_i1 Q505H4 VWC2L_MOUSE 2.00E-21 GO:0032281; GO:0030054; GO:0005615; GO:0030514; GO:0045666; GO:0045202 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; cell junction; extracellular space; negative regulation of BMP signaling pathway; positive regulation of neuron differentiation; synapse IPR001007; von Willebrand factor C domain-containing protein 2-like (Brorin-like) Vwc2l Mus musculus (Mouse) TR24520_c0_g3_i1 Q7TSV9 CP048_MOUSE 2.00E-35 GO:0005881 cytoplasmic microtubule IPR027710; IPR027012; Enkurin domain-containing protein 1 Enkd1 Mus musculus (Mouse) TR24521_c0_g1_i1 Q9H633 RPP21_HUMAN 2.00E-22 GO:0005730; GO:0042493; GO:0004526; GO:0008033 nucleolus; response to drug; ribonuclease P activity; tRNA processing IPR007175; Ribonuclease P protein subunit p21 (RNaseP protein p21) (EC 3.1.26.5) (Ribonuclease P/MRP 21 kDa subunit) (Ribonucleoprotein V) RPP21 C6orf135 CAT60 Homo sapiens (Human) TR24521_c0_g6_i1 Q5TM57 RPP21_MACMU 1.00E-22 GO:0005730; GO:0004526; GO:0008033 nucleolus; ribonuclease P activity; tRNA processing IPR007175; Ribonuclease P protein subunit p21 (RNaseP protein p21) (EC 3.1.26.5) RPP21 Macaca mulatta (Rhesus macaque) TR24525_c0_g1_i1 O08653 TEP1_RAT 7.00E-17 GO:0005524; GO:0003723; GO:0000781; GO:0005634; GO:0030529 "ATP binding; RNA binding; chromosome, telomeric region; nucleus; ribonucleoprotein complex" IPR025139; IPR007111; IPR027417; IPR008850; IPR008858; IPR015943; IPR001680; IPR019775; IPR017986; Telomerase protein component 1 (rTLP1) (Telomerase-associated protein 1) (Telomerase protein 1) (p230) (p240) (p80 telomerase homolog) Tep1 Tlp1 Rattus norvegicus (Rat) TR24525_c3_g1_i1 P97499 TEP1_MOUSE 9.00E-20 GO:0005524; GO:0003723; GO:0000781; GO:0005737; GO:0016363; GO:0003720; GO:0005697; GO:0000722 "ATP binding; RNA binding; chromosome, telomeric region; cytoplasm; nuclear matrix; telomerase activity; telomerase holoenzyme complex; telomere maintenance via recombination" IPR025139; IPR007111; IPR027417; IPR008850; IPR008858; IPR015943; IPR001680; IPR019775; IPR017986; Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog) Tep1 Tp1 Mus musculus (Mouse) TR24527_c0_g1_i1 Q68D06 SLN13_HUMAN 1.00E-07 GO:0005524; GO:0005622 ATP binding; intracellular IPR007421; IPR018647; IPR027417; Schlafen family member 13 SLFN13 Homo sapiens (Human) TR24527_c0_g1_i3 Q68D06 SLN13_HUMAN 5.00E-08 GO:0005524; GO:0005622 ATP binding; intracellular IPR007421; IPR018647; IPR027417; Schlafen family member 13 SLFN13 Homo sapiens (Human) TR24529_c0_g2_i1 O94511 YN67_SCHPO 3.00E-07 GO:0005789; GO:0016631; GO:0030497; GO:0016021; GO:0005739; GO:0019166; GO:0000038 endoplasmic reticulum membrane; enoyl-[acyl-carrier-protein] reductase activity; fatty acid elongation; integral to membrane; mitochondrion; trans-2-enoyl-CoA reductase (NADPH) activity; very long-chain fatty acid metabolic process IPR001104; IPR000626; Putative enoyl reductase C646.07c (EC 1.3.1.38) SPBC646.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR24529_c0_g2_i2 Q28891 S5A1_MACFA 4.00E-65 GO:0003865; GO:0030154; GO:0047751; GO:0005789; GO:0016021; GO:0007548; GO:0008202 3-oxo-5-alpha-steroid 4-dehydrogenase activity; cell differentiation; cholestenone 5-alpha-reductase activity; endoplasmic reticulum membrane; integral to membrane; sex differentiation; steroid metabolic process IPR016636; IPR001104; 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC 1.3.1.22) (SR type 1) (Steroid 5-alpha-reductase 1) (S5AR 1) SRD5A1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR2453_c0_g1_i1 Q8K3K9 GIMA4_RAT 3.00E-18 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) TR24530_c4_g1_i1 P42780 BPRX_DICNO 1.00E-09 GO:0005576; GO:0006508; GO:0004252 extracellular region; proteolysis; serine-type endopeptidase activity IPR008979; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR002884; Extracellular subtilisin-like protease (EC 3.4.21.-) Dichelobacter nodosus (Bacteroides nodosus) TR24530_c5_g1_i1 P28841 NEC2_RAT 7.00E-40 GO:0030425; GO:0009790; GO:0034230; GO:0005615; GO:0030070; GO:0034231; GO:0016020; GO:0007399; GO:0043204; GO:0016540; GO:0006508; GO:0004252; GO:0030133 P27682 dendrite; embryo development; enkephalin processing; extracellular space; insulin processing; islet amyloid polypeptide processing; membrane; nervous system development; perikaryon; protein autoprocessing; proteolysis; serine-type endopeptidase activity; transport vesicle IPR008979; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2) Pcsk2 Nec-2 Nec2 Rpc2 Rattus norvegicus (Rat) TR24531_c0_g1_i1 Q6ZM28 HRG1B_DANRE 2.00E-12 GO:0010008; GO:0015232; GO:0016021; GO:0005765 endosome membrane; heme transporter activity; integral to membrane; lysosomal membrane IPR026218; Heme transporter hrg1-B (Heme-responsive gene 1 protein homolog B) (HRG-1B) (Solute carrier family 48 member 1-A) slc48a1a hrg1b si:ch211-226m16.1 zgc:92662 Danio rerio (Zebrafish) (Brachydanio rerio) TR24531_c0_g1_i2 Q7T3B2 HRG1A_DANRE 4.00E-12 GO:0010008; GO:0048821; GO:0015232; GO:0016021; GO:0005765 endosome membrane; erythrocyte development; heme transporter activity; integral to membrane; lysosomal membrane IPR026218; Heme transporter hrg1-A (zHRG-1) (Heme-responsive gene 1 protein homolog A) (HRG-1A) (Solute carrier family 48 member 1-B) slc48a1b hrg1a zgc:63994 Danio rerio (Zebrafish) (Brachydanio rerio) TR24535_c0_g1_i1 P05935 CALM_LYTPI 1.00E-08 GO:0005509 calcium ion binding IPR011992; IPR002048; Calmodulin (CaM) (Fragment) Lytechinus pictus (Painted sea urchin) TR24535_c0_g1_i2 P02594 CALM_ELEEL 7.00E-93 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) calm Electrophorus electricus (Electric eel) TR24536_c4_g1_i1 Q14590 ZN235_HUMAN 2.00E-65 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) TR24541_c0_g1_i1 Q99943 PLCA_HUMAN 7.00E-75 GO:0003841; GO:0016024; GO:0005789; GO:0006112; GO:0016021; GO:0006654; GO:0031325; GO:0001819; GO:0001961; GO:0044281; GO:0019432 1-acylglycerol-3-phosphate O-acyltransferase activity; CDP-diacylglycerol biosynthetic process; endoplasmic reticulum membrane; energy reserve metabolic process; integral to membrane; phosphatidic acid biosynthetic process; positive regulation of cellular metabolic process; positive regulation of cytokine production; positive regulation of cytokine-mediated signaling pathway; small molecule metabolic process; triglyceride biosynthetic process IPR004552; IPR002123; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 1) (1-AGP acyltransferase 1) (1-AGPAT 1) (Lysophosphatidic acid acyltransferase alpha) (LPAAT-alpha) (Protein G15) AGPAT1 G15 Homo sapiens (Human) TR24556_c3_g1_i1 P55043 RAD_RAT 1.00E-12 GO:0005525; GO:0003924; GO:0030308; GO:0005886; GO:0007264 GTP binding; GTPase activity; negative regulation of cell growth; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR001806; IPR017358; IPR020849; GTP-binding protein RAD (RAD1) (Ras associated with diabetes) Rrad Rad Rattus norvegicus (Rat) TR24559_c4_g1_i1 Q93YS4 AB22G_ARATH 8.00E-09 GO:0005524; GO:0006200; GO:0016887; GO:0016021; GO:0005886; GO:0009414; GO:0010148 ATP binding; ATP catabolic process; ATPase activity; integral to membrane; plasma membrane; response to water deprivation; transpiration IPR003593; IPR013525; IPR003439; IPR017871; IPR027417; ABC transporter G family member 22 (ABC transporter ABCG.22) (AtABCG22) (White-brown complex homolog protein 23) (AtWBC23) ABCG22 WBC23 At5g06530 F15M7.6 Arabidopsis thaliana (Mouse-ear cress) TR24561_c0_g2_i1 Q8WWZ8 OIT3_HUMAN 8.00E-15 GO:0005509; GO:0005635 calcium ion binding; nuclear envelope IPR000742; IPR001881; IPR000152; IPR018097; IPR001507; Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein) OIT3 LZP UNQ826/PRO1753 Homo sapiens (Human) TR24567_c0_g1_i1 P24733 MYS_AEQIR 9.00E-28 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR015650; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, striated muscle" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR24570_c2_g1_i1 P43351 RAD52_HUMAN 2.00E-60 GO:0003677; GO:0000730; GO:0006312; GO:0005654; GO:0007131 Itself; Q06609; P35244; Q14191 DNA binding; DNA recombinase assembly; mitotic recombination; nucleoplasm; reciprocal meiotic recombination IPR004585; IPR007232; DNA repair protein RAD52 homolog RAD52 Homo sapiens (Human) TR24572_c0_g1_i1 P05933 CALM_SCHPO 2.00E-21 GO:0031322; GO:0000935; GO:0005509; GO:0032153; GO:0005829; GO:0071990; GO:0044732; GO:0035841; GO:0005634; GO:0035840; GO:0090307 O14188 ascospore-type prospore-specific spindle pole body remodeling; barrier septum; calcium ion binding; cell division site; cytosol; maintenance of protein location in spindle pole body; mitotic spindle pole body; new growing cell tip; nucleus; old growing cell tip; spindle assembly involved in mitosis IPR011992; IPR018247; IPR002048; Calmodulin (CaM) cam1 SPAC3A12.14 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR24572_c0_g1_i2 O81092 POLC3_OLEEU 4.00E-07 GO:0005509; GO:0012505; GO:0016020 calcium ion binding; endomembrane system; membrane IPR011992; IPR018247; IPR002048; Polcalcin Ole e 3 (Calcium-binding pollen allergen Ole e 3) (allergen Ole e 3) OLE3 Olea europaea (Common olive) TR24572_c0_g2_i1 O74435 CDC31_SCHPO 3.00E-06 GO:0005509; GO:0051301; GO:0034613; GO:0005829; GO:0005825; GO:0007067; GO:0007052; GO:0044732; GO:0005634; GO:0007096; GO:0033047; GO:0030474; GO:0005198 calcium ion binding; cell division; cellular protein localization; cytosol; half bridge of spindle pole body; mitosis; mitotic spindle organization; mitotic spindle pole body; nucleus; regulation of exit from mitosis; regulation of mitotic sister chromatid segregation; spindle pole body duplication; structural molecule activity IPR011992; IPR018247; IPR002048; Cell division control protein 31 cdc31 SPCC1682.04 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR24573_c0_g2_i1 Q9UJN7 ZN391_HUMAN 7.00E-25 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 391 ZNF391 Homo sapiens (Human) TR24574_c0_g1_i1 Q6PBF0 RL8_XENTR 3.00E-157 GO:0015934; GO:0019843; GO:0003735; GO:0006412 large ribosomal subunit; rRNA binding; structural constituent of ribosome; translation IPR012340; IPR022666; IPR014722; IPR002171; IPR023672; IPR022669; IPR022671; IPR014726; IPR008991; 60S ribosomal protein L8 rpl8 TTpA008p15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR24577_c2_g1_i1 D3Z5T1 CCD78_MOUSE 1.00E-14 GO:0048471; GO:0042383; GO:0016529; GO:0003009 perinuclear region of cytoplasm; sarcolemma; sarcoplasmic reticulum; skeletal muscle contraction Coiled-coil domain-containing protein 78 Ccdc78 Mus musculus (Mouse) TR24578_c0_g1_i1 Q9QYK7 RNF11_MOUSE 2.00E-55 GO:0005769; GO:0005634; GO:0042787; GO:0055037; GO:0000151; GO:0006511; GO:0008270 P46935 early endosome; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; recycling endosome; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; zinc ion binding IPR001841; IPR013083; RING finger protein 11 (NEDD4 WW domain-binding protein 2) (Sid 1669) Rnf11 N4wbp2 Sid1669 Mus musculus (Mouse) TR24580_c0_g1_i2 P35003 CTRL_HALRU 1.00E-59 GO:0005615; GO:0006508; GO:0004252 extracellular space; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Chymotrypsin-like serine proteinase (EC 3.4.21.-) Haliotis rufescens (California red abalone) TR24581_c0_g1_i1 Q9D787 PPIL2_MOUSE 1.00E-54 GO:0005634; GO:0003755; GO:0006457; GO:0000413; GO:0000151; GO:0004842 nucleus; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization; ubiquitin ligase complex; ubiquitin-protein ligase activity IPR002130; IPR020892; IPR026951; IPR027799; IPR003613; IPR013083; Peptidyl-prolyl cis-trans isomerase-like 2 (PPIase) (EC 5.2.1.8) (Cyclophilin-60) (Cyclophilin-like protein Cyp-60) (Rotamase PPIL2) Ppil2 Mus musculus (Mouse) TR24581_c2_g1_i1 Q5ZLV2 PPIL3_CHICK 3.00E-07 GO:0003755; GO:0006457; GO:0000413 peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase-like 3 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL3) (Rotamase PPIL3) PPIL3 RCJMB04_4l15 Gallus gallus (Chicken) TR24581_c4_g1_i1 P52012 CYP4_CAEEL 1.00E-55 GO:0030154; GO:0040022; GO:0003755; GO:0006457; GO:0000413; GO:0007548; GO:0000151; GO:0004842 Q21502 cell differentiation; feminization of hermaphroditic germ-line; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization; sex differentiation; ubiquitin ligase complex; ubiquitin-protein ligase activity IPR002130; IPR020892; IPR026951; IPR027799; IPR003613; IPR013083; Peptidyl-prolyl cis-trans isomerase 4 (PPIase 4) (EC 5.2.1.8) (Cyclophilin mog-6) (Cyclophilin-4) (Masculinization of germline protein 6) (Rotamase 4) cyn-4 cyp-4 mog-6 F59E10.2 Caenorhabditis elegans TR24582_c0_g2_i1 Q99JY3 GIMA4_MOUSE 1.00E-18 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Mus musculus (Mouse) TR24593_c0_g1_i1 Q8C7W7 DCR1B_MOUSE 1.00E-24 GO:0008409; GO:0000075; GO:0005813; GO:0000781; GO:0005737; GO:0006289; GO:0005634; GO:0031848; GO:0031860; GO:0031627 "5'-3' exonuclease activity; cell cycle checkpoint; centrosome; chromosome, telomeric region; cytoplasm; nucleotide-excision repair; nucleus; protection from non-homologous end joining at telomere; telomeric 3' overhang formation; telomeric loop formation" IPR001279; IPR011084; 5' exonuclease Apollo (EC 3.1.-.-) (DNA cross-link repair 1B protein) (SNM1 homolog B) Dclre1b Snm1b Mus musculus (Mouse) TR24593_c1_g1_i2 Q9D2R8 RT33_MOUSE 1.00E-19 GO:0005739; GO:0005840 mitochondrion; ribosome IPR013219; "28S ribosomal protein S33, mitochondrial (MRP-S33) (S33mt) (Ganglioside-induced differentiation-associated-protein 3)" Mrps33 Gdap3 Mus musculus (Mouse) TR24595_c0_g1_i1 P21613 KINH_LOLPE 3.00E-06 GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0007018 ATP binding; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement IPR027640; IPR019821; IPR001752; IPR027417; Kinesin heavy chain Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR24596_c0_g1_i1 Q5BKW7 ENPP6_DANRE 1.00E-90 GO:0031225; GO:0019695; GO:0047390; GO:0016042; GO:0006629; GO:0005886 anchored to membrane; choline metabolic process; glycerophosphocholine cholinephosphodiesterase activity; lipid catabolic process; lipid metabolic process; plasma membrane IPR017849; IPR017850; IPR024873; IPR002591; Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 (E-NPP 6) (NPP-6) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Glycerophosphocholine cholinephosphodiesterase) (GPC-Cpde) enpp6 zgc:103605 Danio rerio (Zebrafish) (Brachydanio rerio) TR24597_c2_g1_i1 Q95SX7 RTBS_DROME 3.00E-11 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR24599_c2_g1_i1 A0JM56 LRRC9_XENTR 7.00E-06 IPR001611; IPR025875; IPR003603; Leucine-rich repeat-containing protein 9 lrrc9 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR24599_c2_g1_i2 O43822 CU002_HUMAN 1.00E-43 GO:0030030; GO:0005737; GO:0007010; GO:0005886; GO:0008360 cell projection organization; cytoplasm; cytoskeleton organization; plasma membrane; regulation of cell shape IPR001611; IPR025875; IPR003603; Protein C21orf2 (C21orf-HUMF09G8.5) (YF5/A2) C21orf2 Homo sapiens (Human) TR24601_c1_g2_i2 Q9PT61 OTX5B_XENLA 2.00E-31 GO:0009952; GO:0042706; GO:0005634; GO:0045872; GO:0045944; GO:0043565; GO:0003700; GO:0006351 "anterior/posterior pattern specification; eye photoreceptor cell fate commitment; nucleus; positive regulation of rhodopsin gene expression; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; IPR003025; IPR013851; Homeobox protein otx5-B (Orthodenticle homolog 5-B) (XOtx5b) otx5-b otx5b Xenopus laevis (African clawed frog) TR24603_c3_g1_i1 Q92520 FAM3C_HUMAN 1.00E-13 GO:0005794; GO:0005125; GO:0016023; GO:0005576; GO:0007275 Golgi apparatus; cytokine activity; cytoplasmic membrane-bounded vesicle; extracellular region; multicellular organismal development IPR026101; Protein FAM3C (Interleukin-like EMT inducer) FAM3C ILEI GS3786 Homo sapiens (Human) TR24603_c4_g1_i1 Q91X88 PMGT1_MOUSE 5.00E-106 GO:0000139; GO:0008375; GO:0016021; GO:0006493 Golgi membrane; acetylglucosaminyltransferase activity; integral to membrane; protein O-linked glycosylation IPR004139; Protein modification; protein glycosylation. "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) (EC 2.4.1.-)" Pomgnt1 Mus musculus (Mouse) TR24604_c0_g1_i1 Q9NZJ4 SACS_HUMAN 1.00E-15 GO:0005524; GO:0030424; GO:0070852; GO:0008219; GO:0051087; GO:0030425; GO:0005739; GO:0090084; GO:0005634; GO:0006457 ATP binding; axon; cell body fiber; cell death; chaperone binding; dendrite; mitochondrion; negative regulation of inclusion body assembly; nucleus; protein folding IPR001623; IPR003594; IPR007842; IPR000626; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) TR24609_c1_g1_i1 Q8IX30 SCUB3_HUMAN 5.00E-14 GO:0005509; GO:0009986; GO:0005576; GO:0051291; GO:0051260 P08253; P14780; P37173 calcium ion binding; cell surface; extracellular region; protein heterooligomerization; protein homooligomerization IPR026823; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR009030; IPR011641; "Signal peptide, CUB and EGF-like domain-containing protein 3" SCUBE3 CEGF3 Homo sapiens (Human) TR24610_c1_g1_i1 Q9WVK8 CP46A_MOUSE 3.00E-48 GO:0033781; GO:0006707; GO:0005789; GO:0020037; GO:0016021; GO:0005506; GO:0006805 cholesterol 24-hydroxylase activity; cholesterol catabolic process; endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding; xenobiotic metabolic process IPR001128; IPR017972; IPR002401; Cholesterol 24-hydroxylase (CH24H) (EC 1.14.13.98) (Cytochrome P450 46A1) Cyp46a1 Cyp46 Mus musculus (Mouse) TR24613_c1_g1_i1 Q01082 SPTB2_HUMAN 9.00E-09 GO:0043001; GO:0031430; GO:0007184; GO:0003779; GO:0051693; GO:0030506; GO:0030673; GO:0007411; GO:0007182; GO:0032437; GO:0005829; GO:0071709; GO:0000281; GO:0005730; GO:0005543; GO:0072661; GO:0008091; GO:0014731; GO:0005200 Q9NRI5; P02549; Q13813 Golgi to plasma membrane protein transport; M band; SMAD protein import into nucleus; actin binding; actin filament capping; ankyrin binding; axolemma; axon guidance; common-partner SMAD protein phosphorylation; cuticular plate; cytosol; membrane assembly; mitotic cytokinesis; nucleolus; phospholipid binding; protein targeting to plasma membrane; spectrin; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR001589; IPR001715; IPR001605; IPR011993; IPR001849; IPR018159; IPR016343; IPR002017; "Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)" SPTBN1 SPTB2 Homo sapiens (Human) TR24614_c3_g1_i1 Q28WQ1 KIF1A_DROPS 1.00E-52 GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0005875; GO:0003777; GO:0005543; GO:0048489; GO:0047496 ATP binding; cytoplasm; kinesin complex; microtubule; microtubule associated complex; microtubule motor activity; phospholipid binding; synaptic vesicle transport; vesicle transport along microtubule IPR000253; IPR022140; IPR022164; IPR027640; IPR019821; IPR001752; IPR027417; IPR011993; IPR001849; IPR008984; Kinesin-like protein unc-104 unc-104 GA21168 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR24618_c5_g1_i1 Q8TD10 MIPO1_HUMAN 5.00E-33 GO:0005634 nucleus IPR026175; Mirror-image polydactyly gene 1 protein MIPOL1 Homo sapiens (Human) TR24619_c0_g1_i1 Q8R0F8 FAHD1_MOUSE 3.00E-63 GO:0018773; GO:0047621; GO:0005829; GO:0034545; GO:0046872; GO:0005743 acetylpyruvate hydrolase activity; acylpyruvate hydrolase activity; cytosol; fumarylpyruvate hydrolase activity; metal ion binding; mitochondrial inner membrane IPR002529; IPR011234; "Acylpyruvase FAHD1, mitochondrial (EC 3.7.1.5) (Fumarylacetoacetate hydrolase domain-containing protein 1)" Fahd1 MNCb-4134 Mus musculus (Mouse) TR24622_c0_g1_i1 Q3BAI2 YCX91_PHAAO 1.00E-16 GO:0009507 chloroplast Uncharacterized protein ORF91 Phalaenopsis aphrodite subsp. formosana (Moth orchid) TR24623_c1_g1_i1 O60755 GALR3_HUMAN 5.00E-16 GO:0007631; GO:0004966; GO:0016021; GO:0007611; GO:0007194; GO:0005886 feeding behavior; galanin receptor activity; integral to membrane; learning or memory; negative regulation of adenylate cyclase activity; plasma membrane IPR000405; IPR003908; IPR000276; IPR017452; Galanin receptor type 3 (GAL3-R) (GALR-3) GALR3 GALNR3 Homo sapiens (Human) TR24623_c2_g1_i1 Q8WPA2 AR_BOMMO 4.00E-30 GO:0004930; GO:0042562; GO:0016021; GO:0042923; GO:0005886 G-protein coupled receptor activity; hormone binding; integral to membrane; neuropeptide binding; plasma membrane IPR000405; IPR000276; IPR017452; Allatostatin-A receptor (BAR) AR Bombyx mori (Silk moth) TR24627_c1_g1_i1 Q925F4 RNF37_MOUSE 2.00E-23 GO:0005634; GO:0000209; GO:0000151; GO:0034450; GO:0008270 nucleus; protein polyubiquitination; ubiquitin ligase complex; ubiquitin-ubiquitin ligase activity; zinc ion binding IPR003613; IPR001841; IPR013083; IPR017907; RING finger protein 37 (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (Ubiquitin-conjugating enzyme 7-interacting protein 5) Ubox5 Rnf37 Ubce7ip5 Uip5 Mus musculus (Mouse) TR24627_c2_g1_i2 Q925F4 RNF37_MOUSE 1.00E-11 GO:0005634; GO:0000209; GO:0000151; GO:0034450; GO:0008270 nucleus; protein polyubiquitination; ubiquitin ligase complex; ubiquitin-ubiquitin ligase activity; zinc ion binding IPR003613; IPR001841; IPR013083; IPR017907; RING finger protein 37 (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (Ubiquitin-conjugating enzyme 7-interacting protein 5) Ubox5 Rnf37 Ubce7ip5 Uip5 Mus musculus (Mouse) TR24629_c0_g1_i1 Q7T2D0 SGSM3_DANRE 4.00E-12 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; IPR004012; IPR001452; Small G protein signaling modulator 3 (RUN and TBC1 domain-containing protein 3) sgsm3 rutbc3 Danio rerio (Zebrafish) (Brachydanio rerio) TR24630_c0_g2_i1 Q4R3S3 ANKR7_MACFA 4.00E-16 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 7 ANKRD7 QtsA-14614 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR24632_c0_g2_i1 Q503R4 KLH36_DANRE 2.00E-15 GO:0016567 protein ubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 36 klhl36 zgc:110268 Danio rerio (Zebrafish) (Brachydanio rerio) TR24632_c4_g1_i1 Q8BWA5 KLH31_MOUSE 9.00E-11 GO:0006355; GO:0006351 "regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 31 (Kelch repeat and BTB domain-containing protein 1) (Kelch-like protein KLHL) Klhl31 Kbtbd1 Klhl Mus musculus (Mouse) TR24632_c5_g1_i1 Q96PQ7 KLHL5_HUMAN 8.00E-08 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR006652; Kelch-like protein 5 KLHL5 Homo sapiens (Human) TR24638_c6_g1_i1 Q6DFJ6 TBK1_XENLA 2.00E-94 GO:0005524; GO:0005737; GO:0045087; GO:0004674 ATP binding; cytoplasm; innate immune response; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) tbk1 Xenopus laevis (African clawed frog) TR24642_c1_g1_i1 O09053 WRN_MOUSE 7.00E-33 GO:0008408; GO:0005524; GO:0043140; GO:0006310; GO:0006260; GO:0000731; GO:0051880; GO:0032389; GO:0000403; GO:0006284; GO:0000405; GO:0071480; GO:0009267; GO:0005813; GO:0006302; GO:0009378; GO:0000287; GO:0030145; GO:0010259; GO:0005730; GO:0032066; GO:0005654; GO:0051345; GO:0042981; GO:0040009; GO:0031297; GO:0001302; GO:0010225; GO:0006979; GO:0000723 3'-5' exonuclease activity; ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA recombination; DNA replication; DNA synthesis involved in DNA repair; G-quadruplex DNA binding; MutLalpha complex; Y-form DNA binding; base-excision repair; bubble DNA binding; cellular response to gamma radiation; cellular response to starvation; centrosome; double-strand break repair; four-way junction helicase activity; magnesium ion binding; manganese ion binding; multicellular organismal aging; nucleolus; nucleolus to nucleoplasm transport; nucleoplasm; positive regulation of hydrolase activity; regulation of apoptotic process; regulation of growth rate; replication fork processing; replicative cell aging; response to UV-C; response to oxidative stress; telomere maintenance IPR002562; IPR011545; IPR004589; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR012337; IPR018982; IPR011991; Werner syndrome ATP-dependent helicase homolog (EC 3.6.4.12) (Exonuclease WRN) (EC 3.1.-.-) Wrn Mus musculus (Mouse) TR24643_c0_g1_i1 P57791 FACE2_MOUSE 8.00E-34 GO:0071586; GO:0004197; GO:0005789; GO:0016021 CAAX-box protein processing; cysteine-type endopeptidase activity; endoplasmic reticulum membrane; integral to membrane IPR003675; CAAX prenyl protease 2 (EC 3.4.22.-) (Farnesylated proteins-converting enzyme 2) (FACE-2) (Prenyl protein-specific endoprotease 2) (RCE1 homolog) Rce1 Face2 Rce1a Mus musculus (Mouse) TR24643_c1_g2_i1 Q9Y256 FACE2_HUMAN 4.00E-33 GO:0071586; GO:0004197; GO:0005789; GO:0005887; GO:0004222; GO:0006508 CAAX-box protein processing; cysteine-type endopeptidase activity; endoplasmic reticulum membrane; integral to plasma membrane; metalloendopeptidase activity; proteolysis IPR003675; CAAX prenyl protease 2 (EC 3.4.22.-) (Farnesylated proteins-converting enzyme 2) (FACE-2) (Prenyl protein-specific endoprotease 2) (RCE1 homolog) (hRCE1) RCE1 FACE2 RCE1A RCE1B Homo sapiens (Human) TR24644_c0_g1_i1 Q0P5B7 AAAD_BOVIN 6.00E-60 GO:0004091; GO:0005789; GO:0016021; GO:0004806 carboxylesterase activity; endoplasmic reticulum membrane; integral to membrane; triglyceride lipase activity IPR013094; IPR017157; IPR002168; Arylacetamide deacetylase (EC 3.1.1.3) AADAC Bos taurus (Bovine) TR24644_c0_g1_i3 Q0P5B7 AAAD_BOVIN 2.00E-57 GO:0004091; GO:0005789; GO:0016021; GO:0004806 carboxylesterase activity; endoplasmic reticulum membrane; integral to membrane; triglyceride lipase activity IPR013094; IPR017157; IPR002168; Arylacetamide deacetylase (EC 3.1.1.3) AADAC Bos taurus (Bovine) TR24645_c0_g1_i1 A7TGY3 UBP4_VANPO 5.00E-13 GO:0008234; GO:0031902; GO:0004221; GO:0006511 cysteine-type peptidase activity; late endosome membrane; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; IPR001763; Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) DOA4 UBP4 Kpol_1032p28 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus) TR24645_c0_g2_i1 Q6GNI6 UB22A_XENLA 7.00E-156 GO:0007049; GO:0016568; GO:0008234; GO:0005634; GO:0006355; GO:0006351; GO:0004221; GO:0006511; GO:0008270 "cell cycle; chromatin modification; cysteine-type peptidase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; zinc ion binding" IPR018200; IPR001394; IPR013083; IPR001607; Ubiquitin carboxyl-terminal hydrolase 22-A (EC 3.4.19.12) (Deubiquitinating enzyme 22-A) (Ubiquitin thioesterase 22-A) (Ubiquitin-specific-processing protease 22-A) usp22-a Xenopus laevis (African clawed frog) TR24650_c2_g2_i1 Q2M3M2 SC5A9_HUMAN 2.00E-92 GO:0016021; GO:0005886; GO:0006814; GO:0055085; GO:0005215 integral to membrane; plasma membrane; sodium ion transport; transmembrane transport; transporter activity IPR001734; IPR018212; IPR019900; Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (hSGLT4) (Solute carrier family 5 member 9) SLC5A9 SGLT4 Homo sapiens (Human) TR24650_c3_g1_i1 P96169 SGLT_VIBPH 7.00E-31 GO:0008643; GO:0016021; GO:0005886; GO:0006814; GO:0015293 carbohydrate transport; integral to membrane; plasma membrane; sodium ion transport; symporter activity IPR001734; IPR018212; IPR019900; Sodium/glucose cotransporter (Na(+)/glucose symporter) sglT Vibrio parahaemolyticus TR24650_c3_g3_i1 A8WHP3 SC5A9_DANRE 5.00E-33 GO:0016021; GO:0006814; GO:0055085; GO:0005215 integral to membrane; sodium ion transport; transmembrane transport; transporter activity IPR001734; IPR018212; IPR019900; Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (Solute carrier family 5 member 9) slc5a9 si:dkey-7o6.5 Danio rerio (Zebrafish) (Brachydanio rerio) TR24652_c0_g1_i1 Q4V885 COL12_RAT 1.00E-15 GO:0030246; GO:0005581; GO:0006955; GO:0016021; GO:0030169; GO:0046872; GO:0006910; GO:0008329 "carbohydrate binding; collagen; immune response; integral to membrane; low-density lipoprotein particle binding; metal ion binding; phagocytosis, recognition; signaling pattern recognition receptor activity" IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-12 (Collectin placenta protein 1) (CL-P1) (Nurse cell scavenger receptor 2) Colec12 Clp1 Nsr2 Rattus norvegicus (Rat) TR24658_c2_g1_i1 P31647 S6A11_RAT 1.00E-18 GO:0007420; GO:0042995; GO:0005737; GO:0005332; GO:0005887; GO:0016020; GO:0042165; GO:0006836; GO:0005328; GO:0042493 brain development; cell projection; cytoplasm; gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; membrane; neurotransmitter binding; neurotransmitter transport; neurotransmitter:sodium symporter activity; response to drug IPR000175; IPR002982; Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11) Slc6a11 Gabt3 Gat-3 Gat-b Rattus norvegicus (Rat) TR24658_c2_g1_i2 Q9JMA9 S6A14_MOUSE 3.00E-23 GO:0005275; GO:0006865; GO:0005887; GO:0005328; GO:0009636 amine transmembrane transporter activity; amino acid transport; integral to plasma membrane; neurotransmitter:sodium symporter activity; response to toxic substance IPR000175; Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Colonic system B0+ amino acid transporter CATB0+) (Solute carrier family 6 member 14) Slc6a14 Mus musculus (Mouse) TR24661_c0_g1_i1 Q90YG6 T2AG_ONCMY 1.00E-54 GO:0006355; GO:0005672; GO:0006367 "regulation of transcription, DNA-dependent; transcription factor TFIIA complex; transcription initiation from RNA polymerase II promoter" IPR009083; IPR009088; IPR003194; IPR015871; IPR015872; Transcription initiation factor IIA subunit 2 (General transcription factor IIA subunit 2) (Transcription initiation factor IIA gamma chain) (TFIIA-gamma) gtf2a2 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR24664_c1_g1_i1 Q9ATL3 TIP44_MAIZE 1.00E-22 GO:0016021; GO:0005215; GO:0005774 integral to membrane; transporter activity; vacuolar membrane IPR023271; IPR000425; IPR022357; Aquaporin TIP4-4 (Tonoplast intrinsic protein 4-4) (ZmTIP4-4) (ZmTIP4;4) TIP4-4 Zea mays (Maize) TR24665_c0_g1_i1 P15870 H1D_STRPU 9.00E-18 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR005818; IPR005819; IPR011991; Histone H1-delta Strongylocentrotus purpuratus (Purple sea urchin) TR24674_c1_g1_i1 Q7LHG5 YI31B_YEAST 1.00E-22 GO:0005524; GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0005737; GO:0008233; GO:0006508; GO:0000943; GO:0004523; GO:0004540; GO:0032197; GO:0046797; GO:0008270 "ATP binding; DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; cytoplasm; peptidase activity; proteolysis; retrotransposon nucleocapsid; ribonuclease H activity; ribonuclease activity; transposition, RNA-mediated; viral procapsid maturation; zinc ion binding" IPR001584; IPR024650; IPR021109; IPR005162; IPR012337; IPR000477; IPR001878; Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR24674_c2_g2_i1 Q09575 YRD6_CAEEL 7.00E-26 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR24674_c4_g2_i1 P20825 POL2_DROME 3.00E-36 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR24676_c3_g1_i2 Q95PA1 CPLX_LOLPE 9.00E-13 GO:0005829; GO:0006887; GO:0016020; GO:0006836 cytosol; exocytosis; membrane; neurotransmitter transport IPR008849; Complexin (Synaphin) cpx Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR24678_c0_g1_i1 B0BM36 DHSB_XENTR 5.00E-68 GO:0051537; GO:0051538; GO:0051539; GO:0009055; GO:0046872; GO:0005749; GO:0008177; GO:0006099; GO:0048039 "2 iron, 2 sulfur cluster binding; 3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; electron carrier activity; metal ion binding; mitochondrial respiratory chain complex II; succinate dehydrogenase (ubiquinone) activity; tricarboxylic acid cycle; ubiquinone binding" IPR001041; IPR006058; IPR017896; IPR017900; IPR012675; IPR009051; IPR004489; IPR025192; Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip)" sdhb Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR24678_c1_g2_i1 Q9CQA3 DHSB_MOUSE 1.00E-65 GO:0051537; GO:0051538; GO:0051539; GO:0009055; GO:0046872; GO:0005749; GO:0022904; GO:0008177; GO:0006105; GO:0006099; GO:0048039 "2 iron, 2 sulfur cluster binding; 3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; electron carrier activity; metal ion binding; mitochondrial respiratory chain complex II; respiratory electron transport chain; succinate dehydrogenase (ubiquinone) activity; succinate metabolic process; tricarboxylic acid cycle; ubiquinone binding" IPR001041; IPR006058; IPR017896; IPR017900; IPR012675; IPR009051; IPR004489; IPR025192; Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip)" Sdhb Mus musculus (Mouse) TR24686_c0_g1_i1 Q00719 MDMC_STRMY 2.00E-22 GO:0008171; GO:0017000; GO:0046872 O-methyltransferase activity; antibiotic biosynthetic process; metal ion binding IPR002935; O-methyltransferase MdmC (EC 2.1.1.-) mdmC Streptomyces mycarofaciens TR24689_c0_g2_i1 Q61115 PTC1_MOUSE 4.00E-48 GO:0005794; GO:0007420; GO:0001658; GO:0005901; GO:0061005; GO:0072203; GO:0071397; GO:0015485; GO:0030326; GO:0008544; GO:0005576; GO:0042593; GO:0003007; GO:0008158; GO:0008201; GO:0035137; GO:0005887; GO:0043616; GO:0060603; GO:0060644; GO:0030496; GO:0051782; GO:0050680; GO:0040015; GO:0045668; GO:0043433; GO:0045879; GO:0000122; GO:0021997; GO:0001843; GO:0005113; GO:0048471; GO:0060037; GO:0010875; GO:0072372; GO:0032403; GO:0016485; GO:0072661; GO:0007346; GO:0032880; GO:0010157; GO:0060831; GO:0061053; GO:0021522; GO:0008270 Golgi apparatus; brain development; branching involved in ureteric bud morphogenesis; caveola; cell differentiation involved in kidney development; cell proliferation involved in metanephros development; cellular response to cholesterol; cholesterol binding; embryonic limb morphogenesis; epidermis development; extracellular region; glucose homeostasis; heart morphogenesis; hedgehog receptor activity; heparin binding; hindlimb morphogenesis; integral to plasma membrane; keratinocyte proliferation; mammary gland duct morphogenesis; mammary gland epithelial cell differentiation; midbody; negative regulation of cell division; negative regulation of epithelial cell proliferation; negative regulation of multicellular organism growth; negative regulation of osteoblast differentiation; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of smoothened signaling pathway; negative regulation of transcription from RNA polymerase II promoter; neural plate axis specification; neural tube closure; patched binding; perinuclear region of cytoplasm; pharyngeal system development; positive regulation of cholesterol efflux; primary cilium; protein complex binding; protein processing; protein targeting to plasma membrane; regulation of mitotic cell cycle; regulation of protein localization; response to chlorate; smoothened signaling pathway involved in dorsal/ventral neural tube patterning; somite development; spinal cord motor neuron differentiation; zinc ion binding IPR003392; IPR000731; IPR004766; Protein patched homolog 1 (PTC) (PTC1) Ptch1 Ptch Mus musculus (Mouse) TR24689_c1_g1_i1 Q09614 PTC1_CAEEL 9.00E-34 GO:0051301; GO:0008158; GO:0005887; GO:0007067; GO:0018996 "cell division; hedgehog receptor activity; integral to plasma membrane; mitosis; molting cycle, collagen and cuticulin-based cuticle" IPR003392; IPR000731; Protein patched homolog 1 ptc-1 ZK675.1 Caenorhabditis elegans TR24689_c5_g1_i1 O35595 PTC2_MOUSE 1.00E-46 GO:0008544; GO:0042633; GO:0008158; GO:0016021 epidermis development; hair cycle; hedgehog receptor activity; integral to membrane IPR003392; IPR000731; IPR004766; Protein patched homolog 2 (PTC2) Ptch2 Mus musculus (Mouse) TR24689_c6_g1_i1 Q90693 PTC1_CHICK 9.00E-52 GO:0008158; GO:0005887; GO:0007224 hedgehog receptor activity; integral to plasma membrane; smoothened signaling pathway IPR003392; IPR000731; IPR004766; Protein patched homolog 1 (PTC) (PTC1) PTCH1 PTC PTCH Gallus gallus (Chicken) TR24689_c6_g2_i1 Q13635 PTC1_HUMAN 8.00E-55 GO:0007420; GO:0001658; GO:0005901; GO:0061005; GO:0072203; GO:0071397; GO:0015485; GO:0009953; GO:0030326; GO:0008544; GO:0042593; GO:0003007; GO:0008158; GO:0008201; GO:0035137; GO:0016021; GO:0043231; GO:0043616; GO:0060603; GO:0060644; GO:0030496; GO:0051782; GO:0050680; GO:0040015; GO:0045668; GO:0043433; GO:0045879; GO:0000122; GO:0021997; GO:0001843; GO:0021532; GO:0009887; GO:0048471; GO:0060037; GO:0010875; GO:0072372; GO:0016485; GO:0072661; GO:0007346; GO:0032880; GO:0072001; GO:0010157; GO:0007224; GO:0060831; GO:0061053; GO:0021522 brain development; branching involved in ureteric bud morphogenesis; caveola; cell differentiation involved in kidney development; cell proliferation involved in metanephros development; cellular response to cholesterol; cholesterol binding; dorsal/ventral pattern formation; embryonic limb morphogenesis; epidermis development; glucose homeostasis; heart morphogenesis; hedgehog receptor activity; heparin binding; hindlimb morphogenesis; integral to membrane; intracellular membrane-bounded organelle; keratinocyte proliferation; mammary gland duct morphogenesis; mammary gland epithelial cell differentiation; midbody; negative regulation of cell division; negative regulation of epithelial cell proliferation; negative regulation of multicellular organism growth; negative regulation of osteoblast differentiation; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of smoothened signaling pathway; negative regulation of transcription from RNA polymerase II promoter; neural plate axis specification; neural tube closure; neural tube patterning; organ morphogenesis; perinuclear region of cytoplasm; pharyngeal system development; positive regulation of cholesterol efflux; primary cilium; protein processing; protein targeting to plasma membrane; regulation of mitotic cell cycle; regulation of protein localization; renal system development; response to chlorate; smoothened signaling pathway; smoothened signaling pathway involved in dorsal/ventral neural tube patterning; somite development; spinal cord motor neuron differentiation IPR003392; IPR000731; IPR004766; Protein patched homolog 1 (PTC) (PTC1) PTCH1 PTCH Homo sapiens (Human) TR24690_c0_g1_i2 Q16RX1 MED21_AEDAE 6.00E-34 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR021384; Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) MED21 AAEL010797 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR24690_c2_g1_i1 Q9SAK7 OCT5_ARATH 1.00E-15 GO:0005524; GO:0070417; GO:0071472; GO:0042631; GO:0016021; GO:0006811; GO:0009705; GO:0022857 ATP binding; cellular response to cold; cellular response to salt stress; cellular response to water deprivation; integral to membrane; ion transport; plant-type vacuole membrane; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation/carnitine transporter 5 (AtOCT5) OCT5 5-Oct At1g79410 T8K14.17 Arabidopsis thaliana (Mouse-ear cress) TR24690_c2_g1_i2 Q66J54 S226A_XENLA 4.00E-34 GO:0016021; GO:0015075; GO:0005886 integral to membrane; ion transmembrane transporter activity; plasma membrane IPR020846; IPR016196; IPR004749; IPR005828; IPR005829; Solute carrier family 22 member 6-A (Organic cation transporter 1-A) (Renal organic anion transporter 1-A) (ROAT1-A) slc22a6-a oat1-a Xenopus laevis (African clawed frog) TR24690_c3_g1_i2 Q1LVS8 SVOPL_DANRE 2.00E-06 GO:0016021; GO:0022857 integral to membrane; transmembrane transporter activity IPR011701; IPR020846; IPR016196; IPR005828; Putative transporter SVOPL (SVOP-like protein) svopl si:dkeyp-27e10.2 zgc:101741 Danio rerio (Zebrafish) (Brachydanio rerio) TR24692_c0_g1_i1 Q54DM9 ALG11_DICDI 1.00E-58 GO:0004377; GO:0000026; GO:0016021; GO:0006486 "GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity; alpha-1,2-mannosyltransferase activity; integral to membrane; protein glycosylation" IPR001296; "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC 2.4.1.131) (Asparagine-linked glycosylation protein 11 homolog) (Glycolipid 2-alpha-mannosyltransferase)" alg11 DDB_G0292118 Dictyostelium discoideum (Slime mold) TR24692_c0_g2_i1 Q08B22 ALG11_XENLA 2.00E-88 GO:0004377; GO:0009058; GO:0016021 "GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity; biosynthetic process; integral to membrane" IPR001296; "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC 2.4.1.131) (Asparagine-linked glycosylation protein 11 homolog) (Glycolipid 2-alpha-mannosyltransferase)" alg11 Xenopus laevis (African clawed frog) TR24693_c1_g1_i1 Q8K078 SO4A1_MOUSE 2.00E-63 GO:0016021; GO:0006811; GO:0005886; GO:0005215 integral to membrane; ion transport; plasma membrane; transporter activity IPR002350; IPR020846; IPR016196; IPR004156; Solute carrier organic anion transporter family member 4A1 (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) Slco4a1 Oatp4a1 Oatpe Slc21a12 Mus musculus (Mouse) TR24696_c0_g1_i1 Q15811 ITSN1_HUMAN 1.00E-65 GO:0005089; GO:0097190; GO:0005509; GO:0030054; GO:0005905; GO:0005829; GO:0030139; GO:0005085; GO:0019209; GO:0030027; GO:0043524; GO:0043005; GO:0048011; GO:0005543; GO:0005886; GO:0043065; GO:0051897; GO:0032947; GO:0035023; GO:0051056; GO:0007264; GO:0045202; GO:0048488 P22681; P60953-1; Q9NRI5; P50570; Q3UQN2; O15357; Q925Q9 Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; calcium ion binding; cell junction; coated pit; cytosol; endocytic vesicle; guanyl-nucleotide exchange factor activity; kinase activator activity; lamellipodium; negative regulation of neuron apoptotic process; neuron projection; neurotrophin TRK receptor signaling pathway; phospholipid binding; plasma membrane; positive regulation of apoptotic process; positive regulation of protein kinase B signaling cascade; protein complex scaffold; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; synapse; synaptic vesicle endocytosis IPR000008; IPR000219; IPR011992; IPR018247; IPR002048; IPR000261; IPR001331; IPR000108; IPR011993; IPR001849; IPR001452; Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) ITSN1 ITSN SH3D1A Homo sapiens (Human) TR24696_c1_g1_i1 Q9ZVT9 C2GR1_ARATH 6.00E-12 GO:0016021 integral to membrane IPR000008; IPR004182; C2 and GRAM domain-containing protein At1g03370 At1g03370 F15K9.2 Arabidopsis thaliana (Mouse-ear cress) TR24696_c1_g1_i2 Q5DTI8 ESYT3_MOUSE 3.00E-08 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR000008; Extended synaptotagmin-3 (E-Syt3) Esyt3 D9Ertd280e Fam62c Kiaa4186 Mus musculus (Mouse) TR24697_c4_g1_i1 Q8BVT6 PP2D1_MOUSE 2.00E-27 GO:0003824; GO:0008152 catalytic activity; metabolic process IPR001932; IPR015655; Protein phosphatase 2C-like domain-containing protein 1 Pp2d1 Mus musculus (Mouse) TR24697_c4_g1_i2 Q8BVT6 PP2D1_MOUSE 2.00E-24 GO:0003824; GO:0008152 catalytic activity; metabolic process IPR001932; IPR015655; Protein phosphatase 2C-like domain-containing protein 1 Pp2d1 Mus musculus (Mouse) TR24702_c0_g1_i1 Q8QGX4 PRKDC_CHICK 1.00E-68 GO:0005524; GO:0003677; GO:0004677; GO:0000724; GO:0006303; GO:0070419; GO:0005730; GO:0005654 ATP binding; DNA binding; DNA-dependent protein kinase activity; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; nonhomologous end joining complex; nucleolus; nucleoplasm IPR016024; IPR003152; IPR011009; IPR012582; IPR000403; IPR018936; IPR003151; IPR014009; DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) PRKDC XRCC7 Gallus gallus (Chicken) TR24702_c0_g1_i2 Q7RZT9 ATM_NEUCR 1.00E-19 GO:0005524; GO:0000077; GO:0006281; GO:0000781; GO:0016572; GO:0005634; GO:0004674; GO:0090399; GO:0010212; GO:0000723 "ATP binding; DNA damage checkpoint; DNA repair; chromosome, telomeric region; histone phosphorylation; nucleus; protein serine/threonine kinase activity; replicative senescence; response to ionizing radiation; telomere maintenance" IPR016024; IPR015519; IPR003152; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR021668; Serine/threonine-protein kinase tel-1 (EC 2.7.11.1) (ATM homolog) (DNA-damage checkpoint kinase tel-1) (Telomere length regulation protein 1) tel-1 NCU00274 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR24702_c0_g1_i3 Q9FKS4 ATR_ARATH 2.00E-17 GO:0005524; GO:0006281; GO:0007126; GO:0032504; GO:0005634; GO:0009506; GO:0004674; GO:0032204; GO:0010044; GO:0010332; GO:0043247; GO:0007004 ATP binding; DNA repair; meiosis; multicellular organism reproduction; nucleus; plasmodesma; protein serine/threonine kinase activity; regulation of telomere maintenance; response to aluminum ion; response to gamma radiation; telomere maintenance in response to DNA damage; telomere maintenance via telomerase IPR016024; IPR003152; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR011990; IPR012993; Serine/threonine-protein kinase ATR (AtATR) (EC 2.7.11.1) (Ataxia telangiectasia-mutated and Rad3-related homolog) (DNA repair protein ATR) (Rad3-like protein) (AtRAD3) ATR RAD3 At5g40820 MHK7.5 Arabidopsis thaliana (Mouse-ear cress) TR24702_c1_g1_i1 Q86X60 FA72B_HUMAN 5.00E-21 IPR026768; Protein FAM72B FAM72B Homo sapiens (Human) TR24702_c2_g1_i1 Q8QGX4 PRKDC_CHICK 4.00E-42 GO:0005524; GO:0003677; GO:0004677; GO:0000724; GO:0006303; GO:0070419; GO:0005730; GO:0005654 ATP binding; DNA binding; DNA-dependent protein kinase activity; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; nonhomologous end joining complex; nucleolus; nucleoplasm IPR016024; IPR003152; IPR011009; IPR012582; IPR000403; IPR018936; IPR003151; IPR014009; DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) PRKDC XRCC7 Gallus gallus (Chicken) TR24712_c0_g1_i1 Q9TTY1 TIMP2_CANFA 3.00E-11 GO:0005576; GO:0046872; GO:0008191 extracellular region; metal ion binding; metalloendopeptidase inhibitor activity IPR001134; IPR001820; IPR008993; IPR015613; IPR027465; Metalloproteinase inhibitor 2 (Tissue inhibitor of metalloproteinases 2) (TIMP-2) TIMP2 Canis familiaris (Dog) (Canis lupus familiaris) TR24713_c2_g1_i1 Q8TER0 SNED1_HUMAN 3.00E-09 GO:0005509; GO:0007160; GO:0005576 calcium ion binding; cell-matrix adhesion; extracellular region IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003961; IPR003645; IPR013783; IPR003886; IPR000436; "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" SNED1 Homo sapiens (Human) TR24713_c3_g2_i1 Q6V0I7 FAT4_HUMAN 1.00E-14 GO:0005509; GO:0007156; GO:0016021; GO:0005886 Q9H2K2 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) TR24732_c0_g1_i1 Q67E05 BPI_MOUSE 1.00E-07 GO:0005737; GO:0042742; GO:0005576; GO:0006955; GO:0001530; GO:0016020; GO:0032715; GO:0032717; GO:0043031; GO:0032720 cytoplasm; defense response to bacterium; extracellular region; immune response; lipopolysaccharide binding; membrane; negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; negative regulation of macrophage activation; negative regulation of tumor necrosis factor production IPR017943; IPR001124; IPR017942; Bactericidal permeability-increasing protein (BPI) Bpi Mus musculus (Mouse) TR24743_c1_g1_i1 A1YF12 ZNF16_GORGO 5.00E-69 GO:0003677; GO:0007049; GO:0051301; GO:0072707; GO:0046872; GO:0043066; GO:0005634; GO:1901989; GO:0051781; GO:0008284; GO:0045648; GO:0033674; GO:0045654; GO:0006355; GO:0006351 "DNA binding; cell cycle; cell division; cellular response to sodium dodecyl sulfate; metal ion binding; negative regulation of apoptotic process; nucleus; positive regulation of cell cycle phase transition; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of kinase activity; positive regulation of megakaryocyte differentiation; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 16 ZNF16 Gorilla gorilla gorilla (Lowland gorilla) TR24744_c1_g1_i1 P41823 SY65_APLCA 7.00E-32 GO:0000149; GO:0005509; GO:0030054; GO:0030285; GO:0045955; GO:0016079; GO:0005215 SNARE binding; calcium ion binding; cell junction; integral to synaptic vesicle membrane; negative regulation of calcium ion-dependent exocytosis; synaptic vesicle exocytosis; transporter activity IPR000008; IPR001565; Synaptotagmin-1 (Synaptotagmin I) (p65) SYT1 Aplysia californica (California sea hare) TR24749_c0_g1_i1 Q9VT65 CANB_DROME 9.00E-32 GO:0007298; GO:0005509; GO:0004198; GO:0005737; GO:0016020; GO:0016540; GO:0006508 P12370 border follicle cell migration; calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cytoplasm; membrane; protein autoprocessing; proteolysis IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-B (EC 3.4.22.-) (Calcium-activated neutral proteinase B) (CANP B) [Cleaved into: Calpain-B catalytic subunit 1; Calpain-B catalytic subunit 2] CalpB CG8107 Drosophila melanogaster (Fruit fly) TR24750_c0_g1_i1 O75343 GCYB2_HUMAN 4.00E-13 GO:0005525; GO:0007596; GO:0005737; GO:0004383; GO:0020037; GO:0035556; GO:0046872 GTP binding; blood coagulation; cytoplasm; guanylate cyclase activity; heme binding; intracellular signal transduction; metal ion binding IPR001054; IPR018297; IPR011645; IPR011644; IPR024096; Guanylate cyclase soluble subunit beta-2 (GCS-beta-2) (EC 4.6.1.2) GUCY1B2 Homo sapiens (Human) TR24754_c1_g1_i1 Q861W0 IKBL1_PANTR 2.00E-07 GO:0071222; GO:0032088; GO:0031665; GO:0034122; GO:0032720; GO:0005634 cellular response to lipopolysaccharide; negative regulation of NF-kappaB transcription factor activity; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production; nucleus IPR002110; IPR020683; NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like protein) (I-kappa-B-like protein) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1) NFKBIL1 IKBL Pan troglodytes (Chimpanzee) TR24757_c0_g1_i1 Q17QB3 ASAH1_BOVIN 3.00E-30 GO:0017040; GO:0006629; GO:0005764 ceramidase activity; lipid metabolic process; lysosome IPR016699; IPR003199; Acid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (N-acylsphingosine amidohydrolase) ASAH1 Bos taurus (Bovine) TR24757_c0_g2_i1 Q9D7V9 NAAA_MOUSE 2.00E-56 GO:0016810; GO:0006629; GO:0005764 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; lipid metabolic process; lysosome" IPR016699; IPR003199; N-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.-) (N-acylsphingosine amidohydrolase-like) (ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid amidase subunit alpha; N-acylethanolamine-hydrolyzing acid amidase subunit beta] Naaa Asahl Mus musculus (Mouse) TR24760_c0_g1_i1 Q24407 ATP5J_DROME 1.00E-16 GO:0015986; GO:0015078; GO:0046331; GO:0000276 "ATP synthesis coupled proton transport; hydrogen ion transmembrane transporter activity; lateral inhibition; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)" IPR008387; IPR016349; "ATP synthase-coupling factor 6, mitochondrial (ATPase subunit F6)" ATPsyn-Cf6 CG4412 Drosophila melanogaster (Fruit fly) TR24761_c0_g1_i1 Q5F364 MRP1_CHICK 3.00E-51 GO:0005524; GO:0006200; GO:0042626; GO:0016021; GO:0005886 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; plasma membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP1 RCJMB04_32d20 Gallus gallus (Chicken) TR24761_c0_g2_i1 P39109 YCFI_YEAST 8.00E-40 GO:0005524; GO:0015127; GO:0000329; GO:0015431; GO:0016021; GO:0046686; GO:0010038; GO:0042144 "ATP binding; bilirubin transmembrane transporter activity; fungal-type vacuole membrane; glutathione S-conjugate-exporting ATPase activity; integral to membrane; response to cadmium ion; response to metal ion; vacuole fusion, non-autophagic" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Metal resistance protein YCF1 (Yeast cadmium factor 1) YCF1 YDR135C YD9302.11C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR24776_c0_g1_i1 O75094 SLIT3_HUMAN 2.00E-06 GO:0035385; GO:0061364; GO:0048846; GO:0005509; GO:0032870; GO:0005615; GO:0005739; GO:0050919; GO:0030308; GO:0008285; GO:0070100; GO:0010629; GO:0009887; GO:0051414 Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; calcium ion binding; cellular response to hormone stimulus; extracellular space; mitochondrion; negative chemotaxis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of chemokine-mediated signaling pathway; negative regulation of gene expression; organ morphogenesis; response to cortisol stimulus IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 3 protein (Slit-3) (Multiple epidermal growth factor-like domains protein 5) (Multiple EGF-like domains protein 5) SLIT3 KIAA0814 MEGF5 SLIL2 UNQ691/PRO1336 Homo sapiens (Human) TR24776_c1_g1_i1 Q9EPQ1 TLR1_MOUSE 2.00E-21 GO:0002755; GO:0035354; GO:0007250; GO:0071727; GO:0006952; GO:0042495; GO:0006954; GO:0045087; GO:0016021; GO:0042116; GO:0016020; GO:0045335; GO:0030670; GO:0045410; GO:0042535; GO:0050707; GO:0034130; GO:0004888; GO:0042497 MyD88-dependent toll-like receptor signaling pathway; Toll-like receptor 1-Toll-like receptor 2 protein complex; activation of NF-kappaB-inducing kinase activity; cellular response to triacyl bacterial lipopeptide; defense response; detection of triacyl bacterial lipopeptide; inflammatory response; innate immune response; integral to membrane; macrophage activation; membrane; phagocytic vesicle; phagocytic vesicle membrane; positive regulation of interleukin-6 biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; regulation of cytokine secretion; toll-like receptor 1 signaling pathway; transmembrane signaling receptor activity; triacyl lipopeptide binding IPR000483; IPR001611; IPR025875; IPR000157; IPR027190; IPR017241; Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) Tlr1 Mus musculus (Mouse) TR24779_c0_g1_i1 B0S733 REN3A_DANRE 2.00E-19 GO:0003723; GO:0005737; GO:0051028; GO:0000184; GO:0000166; GO:0005634 "RNA binding; cytoplasm; mRNA transport; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleotide binding; nucleus" IPR005120; IPR012677; Regulator of nonsense transcripts 3A (Up-frameshift suppressor 3 homolog A) upf3a si:dkey-21o13.6 Danio rerio (Zebrafish) (Brachydanio rerio) TR24781_c0_g1_i1 Q3BAI2 YCX91_PHAAO 4.00E-12 GO:0009507 chloroplast Uncharacterized protein ORF91 Phalaenopsis aphrodite subsp. formosana (Moth orchid) TR24782_c0_g2_i1 Q9V6D6 CP301_DROME 8.00E-18 GO:0020037; GO:0005506; GO:0031966; GO:0004497; GO:0016705; GO:0007490 "heme binding; iron ion binding; mitochondrial membrane; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; tergite morphogenesis" IPR001128; IPR002401; "Probable cytochrome P450 301a1, mitochondrial (EC 1.14.-.-) (CYPCCCIA1)" Cyp301a1 CG8587 Drosophila melanogaster (Fruit fly) TR24782_c0_g4_i1 P48416 CP10_LYMST 3.00E-48 GO:0020037; GO:0005506; GO:0004497; GO:0016705 "heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Cytochrome P450 10 (EC 1.14.-.-) (CYPX) CYP10 Lymnaea stagnalis (Great pond snail) TR24784_c1_g1_i2 P86854 PLCL_MYTGA 5.00E-18 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR24784_c2_g1_i1 P82596 PLC_HALLA 8.00E-08 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR24786_c1_g1_i1 Q09274 UN105_CAEEL 2.00E-08 GO:0006816; GO:0030154; GO:0016021; GO:0005216; GO:0015693; GO:0007517; GO:0005272; GO:0035725 calcium ion transport; cell differentiation; integral to membrane; ion channel activity; magnesium ion transport; muscle organ development; sodium channel activity; sodium ion transmembrane transport IPR004726; IPR001873; IPR020903; Degenerin-like protein unc-105 (Uncoordinated protein 105) unc-105 C41C4.5 Caenorhabditis elegans TR24787_c0_g1_i1 O75691 UTP20_HUMAN 1.00E-34 GO:0030686; GO:0005737; GO:0000480; GO:0000447; GO:0000472; GO:0008285; GO:0005730; GO:0005654; GO:0030688; GO:0032040 Q5T8A7 "90S preribosome; cytoplasm; endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); negative regulation of cell proliferation; nucleolus; nucleoplasm; preribosome, small subunit precursor; small-subunit processome" IPR011989; IPR016024; IPR011430; Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) UTP20 DRIM Homo sapiens (Human) TR24792_c0_g1_i1 A3RLT6 RSSA_PINFU 3.00E-72 GO:0022627; GO:0000028; GO:0003735; GO:0006412 cytosolic small ribosomal subunit; ribosomal small subunit assembly; structural constituent of ribosome; translation IPR001865; IPR018130; IPR027498; IPR005707; IPR023591; 40S ribosomal protein SA Pinctada fucata (Pearl oyster) TR24792_c0_g2_i2 C4V7V1 RSSA_NOSCE 2.00E-18 GO:0022627; GO:0000028; GO:0003735; GO:0006412 cytosolic small ribosomal subunit; ribosomal small subunit assembly; structural constituent of ribosome; translation IPR001865; IPR027498; IPR005707; IPR023591; 40S ribosomal protein S0 RPS0 NCER_100543 Nosema ceranae (strain BRL01) (Microsporidian parasite) TR24793_c1_g1_i1 Q96A47 ISL2_HUMAN 9.00E-24 GO:0003677; GO:0045665; GO:0005634; GO:0048935; GO:0031290; GO:0043565; GO:0003700; GO:0021520; GO:0021524; GO:0008270 DNA binding; negative regulation of neuron differentiation; nucleus; peripheral nervous system neuron development; retinal ganglion cell axon guidance; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; spinal cord motor neuron cell fate specification; visceral motor neuron differentiation; zinc ion binding IPR017970; IPR001356; IPR009057; IPR001781; Insulin gene enhancer protein ISL-2 (Islet-2) ISL2 Homo sapiens (Human) TR24796_c1_g1_i2 Q923L3 CSMD1_MOUSE 7.00E-06 GO:0016021 integral to membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 1 (CUB and sushi multiple domains protein 1) Csmd1 Mus musculus (Mouse) TR24796_c2_g2_i1 Q8BNA6 FAT3_MOUSE 2.00E-22 GO:0005509; GO:0007156; GO:0016021; GO:0007275; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; multicellular organismal development; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Protocadherin Fat 3 (FAT tumor suppressor homolog 3) Fat3 Gm1132 Gm510 Mus musculus (Mouse) TR24796_c2_g2_i2 P21783 NOTCH_XENLA 2.00E-35 GO:0007219; GO:0005509; GO:0030154; GO:0016021; GO:0000122; GO:0007399; GO:0005654; GO:0004872; GO:0050793 Notch signaling pathway; calcium ion binding; cell differentiation; integral to membrane; negative regulation of transcription from RNA polymerase II promoter; nervous system development; nucleoplasm; receptor activity; regulation of developmental process IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022362; IPR000800; IPR010660; IPR011656; Neurogenic locus notch protein homolog (xOTCH) notch1 xotch Xenopus laevis (African clawed frog) TR24799_c0_g1_i1 Q3SZZ2 XBP1_BOVIN 7.00E-30 GO:0060691; GO:0031017; GO:0005634; GO:1900103; GO:0043565; GO:0003700; GO:0006351 "epithelial cell maturation involved in salivary gland development; exocrine pancreas development; nucleus; positive regulation of endoplasmic reticulum unfolded protein response; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; X-box-binding protein 1 (XBP-1) XBP1 Bos taurus (Bovine) TR24805_c0_g1_i3 Q96KG7 MEG10_HUMAN 1.00E-13 GO:0016323; GO:0042995; GO:0034109; GO:0016021; GO:0055001; GO:0001891; GO:0043654; GO:0051147; GO:0048641; GO:0014719; GO:0014816; GO:0014841 basolateral plasma membrane; cell projection; homotypic cell-cell adhesion; integral to membrane; muscle cell development; phagocytic cup; recognition of apoptotic cell; regulation of muscle cell differentiation; regulation of skeletal muscle tissue development; satellite cell activation; satellite cell differentiation; satellite cell proliferation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) TR24805_c0_g1_i4 Q06806 TIE1_MOUSE 5.00E-07 GO:0005524; GO:0001525; GO:0001701; GO:0016021; GO:0016525; GO:0030336; GO:0018108; GO:0005886; GO:0045026; GO:0032526; GO:0004714 ATP binding; angiogenesis; in utero embryonic development; integral to membrane; negative regulation of angiogenesis; negative regulation of cell migration; peptidyl-tyrosine phosphorylation; plasma membrane; plasma membrane fusion; response to retinoic acid; transmembrane receptor protein tyrosine kinase activity IPR000742; IPR013032; IPR003961; IPR007110; IPR013783; IPR003599; IPR013151; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) Tie1 Tie Tie-1 Mus musculus (Mouse) TR24811_c0_g1_i1 Q8N567 ZCHC9_HUMAN 2.00E-54 GO:0010923; GO:0003676; GO:0008270 negative regulation of phosphatase activity; nucleic acid binding; zinc ion binding IPR001878; Zinc finger CCHC domain-containing protein 9 ZCCHC9 Homo sapiens (Human) TR24812_c2_g1_i1 P34021 ECR_DROME 5.00E-42 GO:0001077; GO:0008232; GO:0006914; GO:0007409; GO:0007298; GO:0048738; GO:0010002; GO:0007155; GO:0008362; GO:0005737; GO:0030425; GO:0048813; GO:0008340; GO:0035053; GO:0018990; GO:0035072; GO:0004884; GO:0008544; GO:0007390; GO:0035188; GO:0008258; GO:0007488; GO:0007561; GO:0007476; GO:0035193; GO:0035180; GO:0007616; GO:0007517; GO:0016319; GO:0044130; GO:0045892; GO:0016322; GO:0007422; GO:0005700; GO:0043065; GO:0045938; GO:0046982; GO:0035073; GO:0035297; GO:0040034; GO:0035206; GO:0007468; GO:0008231; GO:0042220; GO:0007291; GO:0005496; GO:0000976; GO:0008270 "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; activator ecdysone receptor complex; autophagy; axonogenesis; border follicle cell migration; cardiac muscle tissue development; cardioblast differentiation; cell adhesion; chitin-based embryonic cuticle biosynthetic process; cytoplasm; dendrite; dendrite morphogenesis; determination of adult lifespan; dorsal vessel heart proper cell fate commitment; ecdysis, chitin-based cuticle; ecdysone-mediated induction of salivary gland cell autophagic cell death; ecdysteroid hormone receptor activity; epidermis development; germ-band shortening; hatching; head involution; histoblast morphogenesis; imaginal disc eversion; imaginal disc-derived wing morphogenesis; larval central nervous system remodeling; larval wandering behavior; long-term memory; muscle organ development; mushroom body development; negative regulation of growth of symbiont in host; negative regulation of transcription, DNA-dependent; neuron remodeling; peripheral nervous system development; polytene chromosome; positive regulation of apoptotic process; positive regulation of circadian sleep/wake cycle, sleep; protein heterodimerization activity; pupariation; regulation of Malpighian tubule diameter; regulation of development, heterochronic; regulation of hemocyte proliferation; regulation of rhodopsin gene expression; repressor ecdysone receptor complex; response to cocaine; sperm individualization; steroid binding; transcription regulatory region sequence-specific DNA binding; zinc ion binding" IPR003069; IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Ecdysone receptor (20-hydroxy-ecdysone receptor) (20E receptor) (EcRH) (Ecdysteroid receptor) (Nuclear receptor subfamily 1 group H member 1) EcR NR1H1 CG1765 Drosophila melanogaster (Fruit fly) TR24815_c1_g2_i1 P34479 YMJ2_CAEEL 3.00E-12 GO:0006865; GO:0016021 amino acid transport; integral to membrane IPR013057; Putative amino acid permease F59B2.2 F59B2.2 Caenorhabditis elegans TR24815_c3_g1_i1 Q4KL91 S36A4_XENLA 1.00E-39 GO:0006865; GO:0016021; GO:0015293 amino acid transport; integral to membrane; symporter activity IPR013057; Proton-coupled amino acid transporter 4 (Proton/amino acid transporter 4) (Solute carrier family 36 member 4) slc36a4 pat4 Xenopus laevis (African clawed frog) TR24815_c4_g1_i2 Q811P0 S36A3_MOUSE 2.00E-26 GO:0016021 integral to membrane IPR013057; Proton-coupled amino acid transporter 3 (Proton/amino acid transporter 3) (Solute carrier family 36 member 3) (Tramdorin-2) Slc36a3 Pat3 Tramd2 Mus musculus (Mouse) TR24816_c0_g1_i1 Q5BI42 CAHD1_DROME 2.00E-14 GO:0006816; GO:0016021 calcium ion transport; integral to membrane IPR002035; VWFA and cache domain-containing protein CG16868 CG16868 Drosophila melanogaster (Fruit fly) TR24816_c1_g1_i1 Q6PDJ1 CAHD1_MOUSE 1.00E-20 GO:0006816; GO:0016021 calcium ion transport; integral to membrane IPR004010; IPR013608; IPR002035; VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) TR24817_c3_g1_i1 Q8K0U4 HS12A_MOUSE 6.00E-20 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR24818_c2_g1_i1 H2A0L0 TYRO1_PINMG 2.00E-31 GO:0005576; GO:0046872; GO:0016491 extracellular region; metal ion binding; oxidoreductase activity IPR002227; IPR008922; Tyrosinase-like protein 1 (EC 1.14.18.-) (Tyrosinase 1) Pinctada margaritifera (Black-lipped pearl oyster) TR24820_c0_g1_i1 Q7ZYS1 RL19_XENLA 2.00E-86 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR027547; IPR023638; IPR000196; IPR015972; IPR015974; 60S ribosomal protein L19 rpl19 Xenopus laevis (African clawed frog) TR24822_c0_g1_i3 A8XAC6 BAF1_CAEBR 2.00E-15 GO:0003677; GO:0005634 DNA binding; nucleus IPR004122; Barrier-to-autointegration factor 1 baf-1 CBG10084 Caenorhabditis briggsae TR24824_c0_g1_i2 Q98943 CASP2_CHICK 1.00E-07 GO:0006915; GO:0004197; GO:0005622; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; intracellular; proteolysis; regulation of apoptotic process IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) TR24826_c0_g1_i1 Q90YV2 RL15_ICTPU 1.00E-97 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR024794; IPR000439; IPR020925; IPR012678; 60S ribosomal protein L15 rpl15 Ictalurus punctatus (Channel catfish) (Silurus punctatus) TR24829_c2_g1_i1 O09160 FUT1_MOUSE 5.00E-13 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" Fut1 Mus musculus (Mouse) TR24831_c0_g3_i1 O61231 RL10_DROME 7.00E-119 GO:0051298; GO:0000022; GO:0043025; GO:0005840; GO:0003735; GO:0006412 centrosome duplication; mitotic spindle elongation; neuronal cell body; ribosome; structural constituent of ribosome; translation IPR001197; IPR016180; IPR018255; 60S ribosomal protein L10 (QM protein homolog) (dQM) RpL10 Qm CG17521 Drosophila melanogaster (Fruit fly) TR24832_c0_g1_i1 Q9DCG9 TR112_MOUSE 1.00E-44 GO:0043234; GO:0008276 protein complex; protein methyltransferase activity IPR005651; tRNA methyltransferase 112 homolog (TRM112-like protein) Trmt112 Mus musculus (Mouse) TR24836_c1_g1_i1 Q3TTY0 PLB1_MOUSE 3.00E-48 GO:0016324; GO:0016021; GO:0016042; GO:0004622; GO:0004623 apical plasma membrane; integral to membrane; lipid catabolic process; lysophospholipase activity; phospholipase A2 activity IPR001087; IPR008265; IPR013831; "Phospholipase B1, membrane-associated (Phospholipase B) (Phospholipase B/lipase) (PLB/LIP) [Includes: Phospholipase A2 (EC 3.1.1.4); Lysophospholipase (EC 3.1.1.5)]" Plb1 Plb Mus musculus (Mouse) TR24838_c0_g1_i2 Q96HA9 PX11C_HUMAN 5.00E-31 GO:0005779; GO:0031231; GO:0016559; GO:0043234; GO:0044375 integral to peroxisomal membrane; intrinsic to peroxisomal membrane; peroxisome fission; protein complex; regulation of peroxisome size IPR008733; IPR026510; Peroxisomal membrane protein 11C (Peroxin-11C) (Peroxisomal biogenesis factor 11C) (Protein PEX11 homolog gamma) (PEX11-gamma) PEX11G PEX11C Homo sapiens (Human) TR24839_c3_g1_i1 Q98ST7 MOXD1_CHICK 1.00E-21 GO:0006584; GO:0005507; GO:0004500; GO:0005789; GO:0016021 catecholamine metabolic process; copper ion binding; dopamine beta-monooxygenase activity; endoplasmic reticulum membrane; integral to membrane IPR014784; IPR000323; IPR000945; IPR005018; IPR008977; DBH-like monooxygenase protein 1 (EC 1.14.17.-) (DBH-related protein) (Monooxygenase X) MOXD1 DBHR MOX Gallus gallus (Chicken) TR24839_c5_g1_i1 Q7Z0T3 TEMPT_APLCA 2.00E-13 GO:0005576 extracellular region Temptin Aplysia californica (California sea hare) TR24842_c3_g2_i1 Q80YA3 DDHD1_MOUSE 3.00E-42 GO:0005737; GO:0016787; GO:0016042; GO:0046872 cytoplasm; hydrolase activity; lipid catabolic process; metal ion binding IPR004177; Phospholipase DDHD1 (EC 3.1.1.-) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) Ddhd1 Mus musculus (Mouse) TR24845_c2_g1_i1 Q52KG5 KI26A_MOUSE 1.00E-11 GO:0005524; GO:0005737; GO:0048484; GO:0005871; GO:0005874; GO:0008017; GO:0009968; GO:0001560 Q60631 ATP binding; cytoplasm; enteric nervous system development; kinesin complex; microtubule; microtubule binding; negative regulation of signal transduction; regulation of cell growth by extracellular stimulus IPR027640; IPR001752; IPR027417; Kinesin-like protein KIF26A Kif26a Kiaa1236 Mus musculus (Mouse) TR24845_c3_g1_i1 Q2KJY2 KI26B_HUMAN 9.00E-23 GO:0005524; GO:0005737; GO:0030010; GO:0005871; GO:0005874; GO:0003777; GO:0007018; GO:0022409; GO:0072092 ATP binding; cytoplasm; establishment of cell polarity; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement; positive regulation of cell-cell adhesion; ureteric bud invasion IPR027640; IPR001752; IPR027417; Kinesin-like protein KIF26B KIF26B Homo sapiens (Human) TR24848_c1_g1_i1 O75832 PSD10_HUMAN 2.00E-10 GO:0006977; GO:0000082; GO:0015629; GO:0031145; GO:0002479; GO:0006915; GO:0007253; GO:0005829; GO:0010467; GO:0045111; GO:0016071; GO:0043518; GO:0043409; GO:0032088; GO:0043066; GO:0090201; GO:0000122; GO:0051436; GO:0005654; GO:0030307; GO:0045737; GO:0032436; GO:0051437; GO:0005838; GO:0070682; GO:0000209; GO:0006521; GO:0044281; GO:0016032 P43358; P43686 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G1/S transition of mitotic cell cycle; actin cytoskeleton; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic process; cytoplasmic sequestering of NF-kappaB; cytosol; gene expression; intermediate filament cytoskeleton; mRNA metabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of MAPK cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of apoptotic process; negative regulation of release of cytochrome c from mitochondria; negative regulation of transcription from RNA polymerase II promoter; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of cell growth; positive regulation of cyclin-dependent protein kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; proteasome regulatory particle; proteasome regulatory particle assembly; protein polyubiquitination; regulation of cellular amino acid metabolic process; small molecule metabolic process; viral process" IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK)) PSMD10 Homo sapiens (Human) TR24848_c2_g1_i1 Q01484 ANK2_HUMAN 7.00E-11 GO:0051117; GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0007411; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005829; GO:0005887; GO:0014704; GO:0044325; GO:0086046; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307; GO:0070296 P11532-5; P62993 "ATPase binding; M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; axon guidance; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; cytosol; integral to plasma membrane; intercalated disc; ion channel binding; membrane depolarization involved in regulation of SA node cell action potential; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization; sarcoplasmic reticulum calcium ion transport" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) TR24849_c1_g1_i2 Q4R8V8 CCD37_MACFA 1.00E-41 IPR025252; Coiled-coil domain-containing protein 37 CCDC37 QtsA-11340 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR24850_c1_g1_i1 Q7Z7A1 CNTRL_HUMAN 2.00E-17 GO:0000086; GO:0051301; GO:0005813; GO:0005829 G2/M transition of mitotic cell cycle; cell division; centrosome; cytosol IPR001611; Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110) CNTRL CEP1 CEP110 Homo sapiens (Human) TR24852_c0_g1_i2 Q9UHF1 EGFL7_HUMAN 2.00E-07 GO:0001525; GO:0005509; GO:0005576; GO:0005615; GO:0045746; GO:0030336; GO:0001938; GO:0001570 angiogenesis; calcium ion binding; extracellular region; extracellular space; negative regulation of Notch signaling pathway; negative regulation of cell migration; positive regulation of endothelial cell proliferation; vasculogenesis IPR000742; IPR001881; IPR013032; IPR018097; IPR013111; IPR011489; IPR009030; Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1) EGFL7 MEGF7 UNQ187/PRO1449 Homo sapiens (Human) TR24861_c3_g1_i1 O14511 NRG2_HUMAN 9.00E-09 GO:0038095; GO:0009790; GO:0007173; GO:0005576; GO:0008543; GO:0045087; GO:0016021; GO:0048011; GO:0048015; GO:0005886; GO:0005102 Fc-epsilon receptor signaling pathway; embryo development; epidermal growth factor receptor signaling pathway; extracellular region; fibroblast growth factor receptor signaling pathway; innate immune response; integral to membrane; neurotrophin TRK receptor signaling pathway; phosphatidylinositol-mediated signaling; plasma membrane; receptor binding IPR000742; IPR013032; IPR007110; IPR013783; IPR013098; IPR003598; IPR002154; "Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2) [Cleaved into: Neuregulin-2 (NRG-2) (Divergent of neuregulin-1) (DON-1) (Neural- and thymus-derived activator for ERBB kinases) (NTAK)]" NRG2 NTAK Homo sapiens (Human) TR24863_c1_g2_i1 Q01105 SET_HUMAN 6.00E-44 GO:0003677; GO:0006260; GO:0005829; GO:0005783; GO:0010467; GO:0042393; GO:0016071; GO:0035067; GO:0043524; GO:0045892; GO:0006913; GO:0005654; GO:0006334; GO:0006337; GO:0048471; GO:0043234; GO:0004864; GO:0008601 Q00987; P10644; P63000; Q15573; Q53T94; Q15572; P20226; P17480 "DNA binding; DNA replication; cytosol; endoplasmic reticulum; gene expression; histone binding; mRNA metabolic process; negative regulation of histone acetylation; negative regulation of neuron apoptotic process; negative regulation of transcription, DNA-dependent; nucleocytoplasmic transport; nucleoplasm; nucleosome assembly; nucleosome disassembly; perinuclear region of cytoplasm; protein complex; protein phosphatase inhibitor activity; protein phosphatase type 2A regulator activity" IPR002164; Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) SET Homo sapiens (Human) TR24864_c1_g1_i1 Q92002 MYO1C_LITCT 5.00E-17 GO:0005524; GO:0005737; GO:0003774; GO:0016459; GO:0060171 ATP binding; cytoplasm; motor activity; myosin complex; stereocilium membrane IPR000048; IPR001609; IPR010926; IPR027417; Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) (aMIb) Myo1c Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) TR24864_c2_g1_i1 Q9U1M8 MYOI_DICDI 2.00E-24 GO:0005524; GO:0003779; GO:0030048; GO:0030898; GO:0031252; GO:0000902; GO:0031589; GO:0005829; GO:0030175; GO:0046847; GO:0003774; GO:0016459; GO:0001891; GO:0006909; GO:0043621; GO:0009847 ATP binding; actin binding; actin filament-based movement; actin-dependent ATPase activity; cell leading edge; cell morphogenesis; cell-substrate adhesion; cytosol; filopodium; filopodium assembly; motor activity; myosin complex; phagocytic cup; phagocytosis; protein self-association; spore germination IPR019749; IPR019748; IPR000299; IPR018980; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; IPR011511; IPR001452; Myosin-I heavy chain (Class VII unconventional myosin) (DdMVII) (DdM7) myoI DDB_G0274455 Dictyostelium discoideum (Slime mold) TR24864_c3_g2_i1 Q56A36 HSH2D_DANRE 2.00E-30 IPR000980; Hematopoietic SH2 domain-containing protein homolog hsh2d Danio rerio (Zebrafish) (Brachydanio rerio) TR24864_c3_g2_i2 A6NKC9 SH2D7_HUMAN 1.00E-22 IPR000980; SH2 domain-containing protein 7 SH2D7 Homo sapiens (Human) TR24864_c3_g3_i1 Q56A36 HSH2D_DANRE 5.00E-12 IPR000980; Hematopoietic SH2 domain-containing protein homolog hsh2d Danio rerio (Zebrafish) (Brachydanio rerio) TR24864_c4_g1_i1 Q1EG27 MYO3B_MOUSE 2.00E-60 GO:0005524; GO:0005737; GO:0032433; GO:0000146; GO:0016459; GO:0018105; GO:0018107; GO:0001917; GO:0001750; GO:0051491; GO:0046777; GO:0004674; GO:0050896; GO:0032426; GO:0007601 ATP binding; cytoplasm; filopodium tip; microfilament motor activity; myosin complex; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; photoreceptor inner segment; photoreceptor outer segment; positive regulation of filopodium assembly; protein autophosphorylation; protein serine/threonine kinase activity; response to stimulus; stereocilium bundle tip; visual perception IPR000048; IPR011009; IPR001609; IPR027417; IPR000719; IPR017441; IPR002290; IPR008271; Myosin-IIIb (EC 2.7.11.1) Myo3b Mus musculus (Mouse) TR24864_c6_g1_i1 P04461 MYH7_RABIT 1.00E-06 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR001609; IPR002928; IPR027417; "Myosin-7 (Beta isomyosin) (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) (Fragment)" MYH7 Oryctolagus cuniculus (Rabbit) TR24866_c5_g1_i1 Q13075 BIRC1_HUMAN 2.00E-10 GO:0005524; GO:0016323; GO:0004869; GO:0005737; GO:0006954; GO:0045087; GO:0046872; GO:0043154; GO:0043524; GO:0007399; GO:0017111 ATP binding; basolateral plasma membrane; cysteine-type endopeptidase inhibitor activity; cytoplasm; inflammatory response; innate immune response; metal ion binding; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of neuron apoptotic process; nervous system development; nucleoside-triphosphatase activity IPR003593; IPR001370; IPR007111; IPR027417; Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein) NAIP BIRC1 Homo sapiens (Human) TR24869_c0_g1_i2 P25107 PTH1R_DIDVI 6.00E-65 GO:0007188; GO:0005887; GO:0004991; GO:0017046; GO:0043621 adenylate cyclase-modulating G-protein coupled receptor signaling pathway; integral to plasma membrane; parathyroid hormone receptor activity; peptide hormone binding; protein self-association IPR017981; IPR001879; IPR002170; IPR000832; IPR017983; Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) PTH1R PTHR PTHR1 Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) TR24869_c0_g1_i3 Q5R7Y0 BAI2_PONAB 5.00E-06 GO:0004930; GO:0016021; GO:0016525; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; negative regulation of angiogenesis; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR008077; IPR001879; IPR000832; IPR000203; IPR000884; Brain-specific angiogenesis inhibitor 2 BAI2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR24869_c0_g1_i4 Q8AXU4 CALRL_ONCGO 4.00E-45 GO:0004948; GO:0016021; GO:0005886 calcitonin receptor activity; integral to membrane; plasma membrane IPR003287; IPR017981; IPR003289; IPR001879; IPR000832; IPR017983; Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) calcrl Oncorhynchus gorbuscha (Pink salmon) (Salmo gorbuscha) TR24869_c0_g1_i5 P25107 PTH1R_DIDVI 3.00E-71 GO:0007188; GO:0005887; GO:0004991; GO:0017046; GO:0043621 adenylate cyclase-modulating G-protein coupled receptor signaling pathway; integral to plasma membrane; parathyroid hormone receptor activity; peptide hormone binding; protein self-association IPR017981; IPR001879; IPR002170; IPR000832; IPR017983; Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) PTH1R PTHR PTHR1 Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) TR24872_c0_g1_i1 Q2TBT8 RN151_BOVIN 2.00E-15 GO:0005634; GO:0004842; GO:0008270 nucleus; ubiquitin-protein ligase activity; zinc ion binding IPR013323; IPR008974; IPR001841; IPR013083; IPR017907; IPR013010; IPR001293; RING finger protein 151 RNF151 Bos taurus (Bovine) TR24873_c0_g1_i1 Q5XK91 FBCDB_XENLA 9.00E-57 GO:0008061; GO:0016021; GO:0046872 chitin binding; integral to membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1-B fibcd1-b Xenopus laevis (African clawed frog) TR24876_c0_g1_i1 Q9TWF8 KC3_ANESU 4.00E-10 GO:0005576; GO:0042151; GO:0004867 extracellular region; nematocyst; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Kunitz-type proteinase inhibitor kalicludin-3 (AsKC3) (Kalicludine-3) Anemonia sulcata (Mediterranean snakelocks sea anemone) (Anemonia viridis) TR24879_c0_g1_i1 Q4R0W1 DOIAD_STRRI 1.00E-29 GO:0016491; GO:0008270 oxidoreductase activity; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; Metabolic intermediate biosynthesis; 2-deoxystreptamine biosynthesis; 2-deoxystreptamine from D-glucose 6-phosphate: step 3/4. Antibiotic biosynthesis; ribostamycin biosynthesis. 2-deoxy-scyllo-inosamine dehydrogenase (DOIA dehydrogenase) (EC 1.1.1.329) rbmC ribE Streptomyces ribosidificus TR24882_c0_g1_i1 Q868T3 CCAPR_DROME 4.00E-23 GO:0018990; GO:0005887; GO:0008188; GO:0005000 "ecdysis, chitin-based cuticle; integral to plasma membrane; neuropeptide receptor activity; vasopressin receptor activity" IPR000276; IPR017452; IPR001817; Cardioacceleratory peptide receptor CcapR CG6111 Drosophila melanogaster (Fruit fly) TR24883_c1_g1_i1 Q3ZBG9 PLS2_BOVIN 7.00E-17 GO:0016021; GO:0046872 integral to membrane; metal ion binding IPR005552; Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) TR24884_c5_g1_i2 Q4V8R6 E4F1_DANRE 3.00E-07 GO:0003677; GO:0051301; GO:0005737; GO:0016874; GO:0046872; GO:0007067; GO:0005654; GO:0016567; GO:0040008; GO:0006355; GO:0006351 "DNA binding; cell division; cytoplasm; ligase activity; metal ion binding; mitosis; nucleoplasm; protein ubiquitination; regulation of growth; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Protein modification; protein ubiquitination. Transcription factor E4F1 (EC 6.3.2.-) (Putative E3 ubiquitin-protein ligase E4F1) (Transcription factor E4F) e4f1 zgc:114190 Danio rerio (Zebrafish) (Brachydanio rerio) TR24884_c5_g2_i1 Q0IHB8 OSR2B_XENLA 1.00E-08 GO:0046872; GO:0000122; GO:0003676; GO:0005634; GO:0048793; GO:0006351 "metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleic acid binding; nucleus; pronephros development; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Protein odd-skipped-related 2-B osr2-b osr2 Xenopus laevis (African clawed frog) TR24888_c2_g1_i1 Q6Y7W6 PERQ2_HUMAN 3.00E-18 GO:0008344; GO:0008219; GO:0044267; GO:0007631; GO:0048873; GO:0048009; GO:0031571; GO:0035264; GO:0050881; GO:0017148; GO:0050885; GO:0009791; GO:0021522 adult locomotory behavior; cell death; cellular protein metabolic process; feeding behavior; homeostasis of number of cells within a tissue; insulin-like growth factor receptor signaling pathway; mitotic G1 DNA damage checkpoint; multicellular organism growth; musculoskeletal movement; negative regulation of translation; neuromuscular process controlling balance; post-embryonic development; spinal cord motor neuron differentiation IPR003169; PERQ amino acid-rich with GYF domain-containing protein 2 (GRB10-interacting GYF protein 2) (Trinucleotide repeat-containing gene 15 protein) GIGYF2 KIAA0642 PERQ2 TNRC15 Homo sapiens (Human) TR24890_c2_g2_i1 P82147 L2EFL_DROME 3.00E-14 GO:0007275; GO:0010998 multicellular organismal development; regulation of translational initiation by eIF2 alpha phosphorylation IPR002068; IPR001436; IPR008978; Protein lethal(2)essential for life (Protein Efl21) l(2)efl CG4533 Drosophila melanogaster (Fruit fly) TR24891_c2_g1_i1 Q9ERG0 LIMA1_MOUSE 7.00E-10 GO:0051015; GO:0051017; GO:0003785; GO:0005737; GO:0005925; GO:0030835; GO:0031529; GO:0001725; GO:0008270 actin filament binding; actin filament bundle assembly; actin monomer binding; cytoplasm; focal adhesion; negative regulation of actin filament depolymerization; ruffle organization; stress fiber; zinc ion binding IPR001781; LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) (mEPLIN) Lima1 D15Ertd366e Eplin Mus musculus (Mouse) TR24891_c2_g1_i2 Q8BGB5 LIMD2_MOUSE 8.00E-12 GO:0008270 zinc ion binding IPR001781; LIM domain-containing protein 2 Limd2 Mus musculus (Mouse) TR24896_c0_g1_i1 Q9DAR0 CE049_MOUSE 3.00E-16 IPR027901; Uncharacterized protein C5orf49 homolog (Y regulated sperm protein) Mus musculus (Mouse) TR24901_c0_g1_i1 Q5EA92 AL14E_BOVIN 1.00E-22 GO:0005737 cytoplasm IPR026515; ARL14 effector protein (ARF7 effector protein) ARL14EP ARF7EP Bos taurus (Bovine) TR24904_c4_g1_i1 Q6R5N8 TLR13_MOUSE 9.00E-17 GO:0002755; GO:0005768; GO:0010008; GO:0006954; GO:0045087; GO:0016021; GO:0042803; GO:0019843; GO:0043408; GO:0002237; GO:0009615; GO:0034178; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; endosome; endosome membrane; inflammatory response; innate immune response; integral to membrane; protein homodimerization activity; rRNA binding; regulation of MAPK cascade; response to molecule of bacterial origin; response to virus; toll-like receptor 13 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR003591; IPR000157; IPR027196; Toll-like receptor 13 Tlr13 Mus musculus (Mouse) TR24904_c4_g1_i2 Q6QNU9 TLR12_MOUSE 8.00E-06 GO:0006954; GO:0045087; GO:0016021; GO:0009617; GO:0034174; GO:0004888 inflammatory response; innate immune response; integral to membrane; response to bacterium; toll-like receptor 12 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR003591; IPR000157; IPR027195; Toll-like receptor 12 Tlr12 Gm1365 Mus musculus (Mouse) TR24909_c0_g1_i1 Q5F3W5 SUV92_CHICK 2.00E-10 GO:0007049; GO:0030154; GO:0000785; GO:0006333; GO:0006338; GO:0000775; GO:0051567; GO:0046974; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "cell cycle; cell differentiation; chromatin; chromatin assembly or disassembly; chromatin remodeling; chromosome, centromeric region; histone H3-K9 methylation; histone methyltransferase activity (H3-K9 specific); nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR023780; IPR000953; IPR016197; IPR023779; IPR011381; IPR003616; IPR007728; IPR001214; Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.43) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2) SUV39H2 RCJMB04_5f7 Gallus gallus (Chicken) TR24909_c1_g1_i1 Q9H5I1 SUV92_HUMAN 3.00E-97 GO:0030154; GO:0000785; GO:0006333; GO:0003682; GO:0006338; GO:0000775; GO:0046974; GO:0007140; GO:0005720; GO:0006355; GO:0006351; GO:0008270 Q9BXL8; Q8N5Z5; Q8TBB5; Q9Y605; P16333; Q5T6S3; Q9UDV6 "cell differentiation; chromatin; chromatin assembly or disassembly; chromatin binding; chromatin remodeling; chromosome, centromeric region; histone methyltransferase activity (H3-K9 specific); male meiosis; nuclear heterochromatin; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR023780; IPR000953; IPR016197; IPR023779; IPR011381; IPR003616; IPR007728; IPR001214; Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2) SUV39H2 KMT1B Homo sapiens (Human) TR2491_c0_g1_i1 Q6ZPD9 D19L3_HUMAN 2.00E-29 GO:0016021; GO:0016757 "integral to membrane; transferase activity, transferring glycosyl groups" IPR018732; Probable C-mannosyltransferase DPY19L3 (EC 2.4.1.-) (Dpy-19-like protein 3) (Protein dpy-19 homolog 3) DPY19L3 Homo sapiens (Human) TR24910_c0_g1_i1 Q9WUW9 S1C2A_RAT 4.00E-34 GO:0005764; GO:0008146 lysosome; sulfotransferase activity IPR027417; IPR000863; Sulfotransferase 1C2A (ST1C2A) (rSULT1C2A) (EC 2.8.2.-) (Sulfotransferase K2) Sult1c2a Sultk2 Rattus norvegicus (Rat) TR24911_c0_g1_i1 P05099 MATN1_CHICK 2.00E-33 GO:0005578 proteinaceous extracellular matrix IPR000742; IPR013032; IPR019466; IPR002035; Cartilage matrix protein (Matrilin-1) MATN1 CMP Gallus gallus (Chicken) TR24911_c0_g2_i1 O42401 MATN3_CHICK 1.00E-15 GO:0005509; GO:0005578 calcium ion binding; proteinaceous extracellular matrix IPR000742; IPR001881; IPR013032; IPR009030; IPR019466; IPR002035; Matrilin-3 MATN3 Gallus gallus (Chicken) TR24912_c2_g1_i1 Q8T674 ABCGK_DICDI 2.00E-23 GO:0005524; GO:0043190; GO:0042626; GO:0016021 "ATP binding; ATP-binding cassette (ABC) transporter complex; ATPase activity, coupled to transmembrane movement of substances; integral to membrane" IPR003593; IPR013525; IPR000412; IPR003439; IPR017871; IPR027417; ABC transporter G family member 20 (ABC transporter ABCG.20) abcG20 DDB_G0267430 Dictyostelium discoideum (Slime mold) TR24914_c1_g1_i1 Q54P13 ABCC8_DICDI 5.00E-61 GO:0005524; GO:0042626; GO:0031154; GO:0016021; GO:0031288 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; culmination involved in sorocarp development; integral to membrane; sorocarp morphogenesis" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; ABC transporter C family member 8 (ABC transporter ABCC.8) abcC8 DDB_G0284867 Dictyostelium discoideum (Slime mold) TR24914_c1_g2_i1 B2RX12 MRP3_MOUSE 1.00E-82 GO:0005524; GO:0006200; GO:0042626; GO:0005887 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to plasma membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) Abcc3 Cmoat2 Mrp3 Mus musculus (Mouse) TR24914_c3_g1_i1 Q8CG09 MRP1_RAT 3.00E-80 GO:0005524; GO:0016323; GO:0060326; GO:0005737; GO:0043215; GO:0046618; GO:0015562; GO:0015431; GO:0034775; GO:0034634; GO:0005887; GO:0034040; GO:0005324; GO:1901215; GO:0016491; GO:0033700; GO:0015911; GO:0030335; GO:0006979; GO:0046624; GO:0008559 ATP binding; basolateral plasma membrane; cell chemotaxis; cytoplasm; daunorubicin transport; drug export; efflux transmembrane transporter activity; glutathione S-conjugate-exporting ATPase activity; glutathione transmembrane transport; glutathione transmembrane transporter activity; integral to plasma membrane; lipid-transporting ATPase activity; long-chain fatty acid transporter activity; negative regulation of neuron death; oxidoreductase activity; phospholipid efflux; plasma membrane long-chain fatty acid transport; positive regulation of cell migration; response to oxidative stress; sphingolipid transporter activity; xenobiotic-transporting ATPase activity IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR018170; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) Abcc1 Mrp1 Rattus norvegicus (Rat) TR24918_c1_g1_i1 Q99715 COCA1_HUMAN 1.00E-11 GO:0007155; GO:0030574; GO:0030199; GO:0005595; GO:0005788; GO:0022617; GO:0030020; GO:0005615; GO:0070062; GO:0001501 cell adhesion; collagen catabolic process; collagen fibril organization; collagen type XII; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular matrix structural constituent conferring tensile strength; extracellular space; extracellular vesicular exosome; skeletal system development IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) TR24922_c0_g1_i1 Q8IXM3 RM41_HUMAN 2.00E-13 GO:0006915; GO:0007049; GO:0005762; GO:0003735; GO:0006412 Q969Q1 apoptotic process; cell cycle; mitochondrial large ribosomal subunit; structural constituent of ribosome; translation IPR019189; "39S ribosomal protein L41, mitochondrial (L41mt) (MRP-L41) (39S ribosomal protein L27 homolog) (Bcl-2-interacting mitochondrial ribosomal protein L41) (Cell proliferation-inducing gene 3 protein) (MRP-L27 homolog)" MRPL41 BMRP MRPL27 RPML27 PIG3 Homo sapiens (Human) TR24927_c0_g1_i1 B0BMJ2 CC42M_XENTR 2.00E-76 IPR025252; Coiled-coil domain-containing protein 42 like-2 TNeu058c09.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR24927_c0_g1_i2 A7S8T5 CCD42_NEMVE 6.00E-115 IPR025252; Coiled-coil domain-containing protein 42 homolog v1g187067 Nematostella vectensis (Starlet sea anemone) TR24934_c0_g1_i1 P60954 NOL4_MOUSE 2.00E-39 GO:0005730 nucleolus IPR026747; Nucleolar protein 4 Nol4 Gm1262 Mus musculus (Mouse) TR24934_c1_g1_i1 Q96MY1 CT112_HUMAN 3.00E-48 Uncharacterized protein C20orf112 C20orf112 C20orf113 Homo sapiens (Human) TR24935_c0_g1_i2 P54318 LIPR2_RAT 2.00E-32 GO:0047372; GO:0005509; GO:0005615; GO:0047714; GO:0019376; GO:0004620; GO:0009395; GO:0009791; GO:0032094; GO:0051384; GO:0043434; GO:0004806; GO:0042589 acylglycerol lipase activity; calcium ion binding; extracellular space; galactolipase activity; galactolipid catabolic process; phospholipase activity; phospholipid catabolic process; post-embryonic development; response to food; response to glucocorticoid stimulus; response to peptide hormone stimulus; triglyceride lipase activity; zymogen granule membrane IPR000734; IPR008976; IPR013818; IPR002331; IPR016272; IPR001024; Pancreatic lipase-related protein 2 (PL-RP2) (EC 3.1.1.26) (EC 3.1.1.3) (Galactolipase) (Secretory glycoprotein GP-3) Pnliprp2 Plrp2 Rattus norvegicus (Rat) TR24936_c0_g1_i1 B2RXR6 ANR44_MOUSE 2.00E-20 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) Ankrd44 Mus musculus (Mouse) TR24939_c0_g1_i3 A7RT29 HBXIP_NEMVE 3.00E-21 GO:0071986; GO:0071230; GO:0005764; GO:0043066; GO:0043154; GO:0032008; GO:0061462; GO:0008361; GO:0019079 Ragulator complex; cellular response to amino acid stimulus; lysosome; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of TOR signaling cascade; protein localization to lysosome; regulation of cell size; viral genome replication IPR024135; Ragulator complex protein LAMTOR5 homolog (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5) v1g226489 Nematostella vectensis (Starlet sea anemone) TR24940_c0_g1_i1 P0C8Y1 MZT1_DANRE 7.00E-20 GO:0005813; GO:0033566; GO:0008274; GO:0005819 centrosome; gamma-tubulin complex localization; gamma-tubulin ring complex; spindle IPR022214; Mitotic-spindle organizing protein 1 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1) mzt1 mozart1 Danio rerio (Zebrafish) (Brachydanio rerio) TR24949_c0_g1_i1 Q15036 SNX17_HUMAN 9.00E-60 GO:0005794; GO:0006707; GO:0016023; GO:0030659; GO:0005829; GO:0005769; GO:0016197; GO:0006886; GO:0050750; GO:0016020; GO:0035091; GO:0006898; GO:0030100; GO:0007165 P16333; P19174 Golgi apparatus; cholesterol catabolic process; cytoplasmic membrane-bounded vesicle; cytoplasmic vesicle membrane; cytosol; early endosome; endosomal transport; intracellular protein transport; low-density lipoprotein particle receptor binding; membrane; phosphatidylinositol binding; receptor-mediated endocytosis; regulation of endocytosis; signal transduction IPR001683; IPR000159; Sorting nexin-17 SNX17 KIAA0064 Homo sapiens (Human) TR24949_c1_g1_i1 Q5RID7 SNX17_DANRE 2.00E-36 GO:0016023; GO:0030659; GO:0005829; GO:0005769; GO:0035091; GO:0015031; GO:0007165 cytoplasmic membrane-bounded vesicle; cytoplasmic vesicle membrane; cytosol; early endosome; phosphatidylinositol binding; protein transport; signal transduction IPR001683; IPR000159; Sorting nexin-17 snx17 si:ch211-101l18.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR24949_c1_g4_i1 Q19532 YTDK_CAEEL 2.00E-06 GO:0007154; GO:0035091 cell communication; phosphatidylinositol binding IPR001683; PX domain-containing protein F17H10.3 F17H10.3 Caenorhabditis elegans TR2495_c0_g1_i1 P16157 ANK1_HUMAN 2.00E-13 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR24951_c2_g1_i1 Q9NUJ3 T11L1_HUMAN 7.00E-49 GO:0005874 microtubule IPR008862; T-complex protein 11-like protein 1 TCP11L1 Homo sapiens (Human) TR24953_c0_g1_i1 Q8N6D5 ANR29_HUMAN 9.00E-09 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 29 ANKRD29 Homo sapiens (Human) TR24954_c0_g2_i1 C8YR32 LOXH1_MOUSE 4.00E-12 GO:0005262; GO:0050982; GO:0016020; GO:0007605; GO:0032420 calcium channel activity; detection of mechanical stimulus; membrane; sensory perception of sound; stereocilium IPR008976; IPR001024; Lipoxygenase homology domain-containing protein 1 Loxhd1 Mus musculus (Mouse) TR24956_c1_g1_i1 Q9VVR0 Y3380_DROME 6.00E-07 Uncharacterized protein CG13380 CG13380 Drosophila melanogaster (Fruit fly) TR24957_c2_g2_i1 A6NK53 ZN233_HUMAN 1.00E-62 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 233 ZNF233 Homo sapiens (Human) TR24961_c0_g1_i1 Q7Z7L9 ZSCA2_HUMAN 3.00E-07 GO:0003677; GO:0030154; GO:0046872; GO:0007275; GO:0005634; GO:0003700; GO:0007283; GO:0006351 "DNA binding; cell differentiation; metal ion binding; multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity; spermatogenesis; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) ZSCAN2 ZFP29 ZNF854 Homo sapiens (Human) TR24961_c0_g2_i1 Q8BX22 SALL4_MOUSE 2.00E-09 GO:0003677; GO:0005737; GO:0030326; GO:0000792; GO:0001833; GO:0046872; GO:0000122; GO:0001843; GO:0005634; GO:0045944; GO:0019827; GO:0005667; GO:0006351; GO:0003281 Q9R190; Q7TSZ8; Q9UHY1; O70230 "DNA binding; cytoplasm; embryonic limb morphogenesis; heterochromatin; inner cell mass cell proliferation; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; neural tube closure; nucleus; positive regulation of transcription from RNA polymerase II promoter; stem cell maintenance; transcription factor complex; transcription, DNA-dependent; ventricular septum development" IPR007087; IPR015880; IPR013087; Sal-like protein 4 (Zinc finger protein SALL4) Sall4 Mus musculus (Mouse) TR24963_c3_g1_i1 Q4VBE4 EGFLA_MOUSE 3.00E-08 GO:0005604; GO:0030054; GO:0030198; GO:0005539; GO:0005614; GO:0019800; GO:0010811; GO:0045202 Q62165 basement membrane; cell junction; extracellular matrix organization; glycosaminoglycan binding; interstitial matrix; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; positive regulation of cell-substrate adhesion; synapse IPR008985; IPR013320; IPR000742; IPR013032; IPR003961; IPR013783; IPR001791; "Pikachurin (EGF-like, fibronectin type-III and laminin G-like domain-containing protein) (Nectican)" Egflam Mus musculus (Mouse) TR24963_c4_g1_i2 P70407 CADH9_MOUSE 1.00E-25 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR000233; IPR027397; Cadherin-9 (T1-cadherin) Cdh9 Mus musculus (Mouse) TR24963_c5_g1_i1 O15943 CADN_DROME 9.00E-56 GO:0045467; GO:0045463; GO:0030424; GO:0048846; GO:0007412; GO:0007413; GO:0008013; GO:0005509; GO:0016339; GO:0050839; GO:0044331; GO:0005911; GO:0030425; GO:0007156; GO:0005887; GO:0050774; GO:0016318; GO:0004872; GO:0048841; GO:0031290 R7 cell development; R8 cell development; axon; axon extension involved in axon guidance; axon target recognition; axonal fasciculation; beta-catenin binding; calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; cell-cell adhesion mediated by cadherin; cell-cell junction; dendrite; homophilic cell adhesion; integral to plasma membrane; negative regulation of dendrite morphogenesis; ommatidial rotation; receptor activity; regulation of axon extension involved in axon guidance; retinal ganglion cell axon guidance IPR002126; IPR015919; IPR020894; IPR000233; IPR027397; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR009030; IPR001791; Neural-cadherin (Cadherin-N) (dN-cadherin) CadN CG7100 Drosophila melanogaster (Fruit fly) TR24968_c0_g1_i1 Q8CFK2 TF3B_MOUSE 2.00E-91 GO:0006352; GO:0005634; GO:0045893; GO:0043488; GO:0008270 "DNA-dependent transcription, initiation; nucleus; positive regulation of transcription, DNA-dependent; regulation of mRNA stability; zinc ion binding" IPR011665; IPR013763; IPR000812; IPR013150; IPR013137; Transcription factor IIIB 90 kDa subunit (TFIIIB90) (mTFIIIB90) (B-related factor 1) (BRF-1) Brf1 Mus musculus (Mouse) TR24968_c0_g1_i2 P48513 TF2B_SOYBN 2.00E-07 GO:0006352; GO:0005634; GO:0006355; GO:0008270 "DNA-dependent transcription, initiation; nucleus; regulation of transcription, DNA-dependent; zinc ion binding" IPR013763; IPR000812; IPR023486; IPR013150; IPR013137; Transcription initiation factor IIB (General transcription factor TFIIB) TFIIB1 Glycine max (Soybean) (Glycine hispida) TR24971_c0_g1_i1 Q05793 PGBM_MOUSE 3.00E-12 GO:0005796; GO:0001525; GO:0005605; GO:0007420; GO:0048738; GO:0060351; GO:0002062; GO:0048704; GO:0001958; GO:0030198; GO:0046872; GO:0008104 Golgi lumen; angiogenesis; basal lamina; brain development; cardiac muscle tissue development; cartilage development involved in endochondral bone morphogenesis; chondrocyte differentiation; embryonic skeletal system morphogenesis; endochondral ossification; extracellular matrix organization; metal ion binding; protein localization IPR008985; IPR013320; IPR000742; IPR013032; IPR002049; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR018031; IPR000034; IPR001791; IPR023415; IPR002172; IPR000082; Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) [Cleaved into: Endorepellin; LG3 peptide] Hspg2 Mus musculus (Mouse) TR24973_c4_g1_i1 Q5DRC7 PCDB7_PANTR 2.00E-22 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR013164; Protocadherin beta-7 (PCDH-beta-7) PCDHB7 Pan troglodytes (Chimpanzee) TR24973_c6_g1_i1 Q24292 DS_DROME 2.00E-07 GO:0005509; GO:0016339; GO:0050839; GO:0000904; GO:0008283; GO:0045317; GO:0045198; GO:0001737; GO:0007156; GO:0007480; GO:0005887; GO:0090176; GO:0016318; GO:0018149; GO:0004872; GO:0090175; GO:0035159; GO:0004871; GO:0035222 "calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; cell morphogenesis involved in differentiation; cell proliferation; equator specification; establishment of epithelial cell apical/basal polarity; establishment of imaginal disc-derived wing hair orientation; homophilic cell adhesion; imaginal disc-derived leg morphogenesis; integral to plasma membrane; microtubule cytoskeleton organization involved in establishment of planar polarity; ommatidial rotation; peptide cross-linking; receptor activity; regulation of establishment of planar polarity; regulation of tube length, open tracheal system; signal transducer activity; wing disc pattern formation" IPR002126; IPR015919; IPR020894; IPR000233; Protein dachsous (Adherin) ds CG17941 Drosophila melanogaster (Fruit fly) TR24979_c1_g2_i1 Q29460 PA1B3_BOVIN 7.00E-63 GO:0003847; GO:0005737; GO:0016042; GO:0007283 1-alkyl-2-acetylglycerophosphocholine esterase activity; cytoplasm; lipid catabolic process; spermatogenesis IPR013831; Platelet-activating factor acetylhydrolase IB subunit gamma (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma) PAFAH1B3 PAFAHG Bos taurus (Bovine) TR2498_c0_g1_i1 P16112 PGCA_HUMAN 2.00E-14 GO:0005796; GO:0030246; GO:0005975; GO:0007155; GO:0030198; GO:0005201; GO:0005576; GO:0005540; GO:0018146; GO:0042340; GO:0043202; GO:0046872; GO:0005578; GO:0006508; GO:0001501 Golgi lumen; carbohydrate binding; carbohydrate metabolic process; cell adhesion; extracellular matrix organization; extracellular matrix structural constituent; extracellular region; hyaluronic acid binding; keratan sulfate biosynthetic process; keratan sulfate catabolic process; lysosomal lumen; metal ion binding; proteinaceous extracellular matrix; proteolysis; skeletal system development IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR007110; IPR013783; IPR003006; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2] ACAN AGC1 CSPG1 MSK16 Homo sapiens (Human) TR2498_c0_g2_i1 P86854 PLCL_MYTGA 1.00E-20 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR24980_c0_g1_i1 Q5RF32 BHMT2_PONAB 4.00E-31 GO:0047150; GO:0005737; GO:0008898; GO:0009086; GO:0008270 betaine-homocysteine S-methyltransferase activity; cytoplasm; homocysteine S-methyltransferase activity; methionine biosynthetic process; zinc ion binding IPR017226; IPR003726; Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2) BHMT2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR24982_c4_g1_i1 Q19269 NAS14_CAEEL 2.00E-16 GO:0005576; GO:0004222; GO:0006508; GO:0008270 extracellular region; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR001506; IPR006026; IPR003582; Zinc metalloproteinase nas-14 (EC 3.4.24.21) (Nematode astacin 14) nas-14 F09E8.6 Caenorhabditis elegans TR24982_c4_g2_i1 Q20958 NAS29_CAEEL 3.00E-13 GO:0005576; GO:0004222; GO:0006508; GO:0008270 extracellular region; metalloendopeptidase activity; proteolysis; zinc ion binding IPR000859; IPR013032; IPR024079; IPR001506; IPR017050; IPR006026; Zinc metalloproteinase nas-29 (EC 3.4.24.21) (Nematode astacin 29) nas-29 F58A6.4 Caenorhabditis elegans TR24983_c0_g4_i2 P95506 HEMN_PASHA 1.00E-07 GO:0051539; GO:0051989; GO:0005737; GO:0046872; GO:0006782 "4 iron, 4 sulfur cluster binding; coproporphyrinogen dehydrogenase activity; cytoplasm; metal ion binding; protoporphyrinogen IX biosynthetic process" IPR023404 Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route): step 1/1. Oxygen-independent coproporphyrinogen-III oxidase (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.99.22) (Fragment) hemN Pasteurella haemolytica (Mannheimia haemolytica) TR24983_c0_g4_i3 A4IGH2 RSAD1_DANRE 4.00E-133 GO:0051539; GO:0004109; GO:0046872; GO:0005739; GO:0006779 "4 iron, 4 sulfur cluster binding; coproporphyrinogen oxidase activity; metal ion binding; mitochondrion; porphyrin-containing compound biosynthetic process" IPR004559; IPR006638; IPR010723; IPR007197; IPR023404; "Radical S-adenosyl methionine domain-containing protein 1, mitochondrial (EC 1.3.99.-) (Oxygen-independent coproporphyrinogen-III oxidase-like protein RSAD1)" rsad1 Danio rerio (Zebrafish) (Brachydanio rerio) TR24985_c0_g1_i1 Q4LDE5 SVEP1_HUMAN 2.00E-14 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) TR24985_c0_g1_i2 Q80T79 CSMD3_MOUSE 3.00E-12 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 3 (CUB and sushi multiple domains protein 3) Csmd3 Kiaa1894 Mus musculus (Mouse) TR24986_c0_g1_i1 Q5M9B1 SPSB3_XENLA 1.00E-33 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR001870; IPR008985; IPR001496; IPR003877; Protein modification; protein ubiquitination. SPRY domain-containing SOCS box protein 3 (SSB-3) spsb3 Xenopus laevis (African clawed frog) TR24987_c2_g1_i1 Q5XK92 CIP2A_XENLA 3.00E-45 GO:0006526; GO:0005737; GO:0004358; GO:0016021 arginine biosynthetic process; cytoplasm; glutamate N-acetyltransferase activity; integral to membrane IPR002813; IPR016024; Protein CIP2A homolog Xenopus laevis (African clawed frog) TR24992_c0_g2_i1 Q9NUV9 GIMA4_HUMAN 7.00E-13 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR24995_c0_g4_i1 Q6DFM9 TOM20_XENTR 3.00E-36 GO:0016021; GO:0005742; GO:0006605 integral to membrane; mitochondrial outer membrane translocase complex; protein targeting IPR002056; IPR022422; IPR023392; Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20) tomm20 TNeu065b24.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR25001_c1_g1_i1 Q64669 NQO1_MOUSE 2.00E-21 GO:0003955; GO:0007568; GO:0005829; GO:0043086; GO:0043025; GO:0043525; GO:0032355; GO:0045471; GO:0007584; GO:0006979; GO:0004784; GO:0006801 NAD(P)H dehydrogenase (quinone) activity; aging; cytosol; negative regulation of catalytic activity; neuronal cell body; positive regulation of neuron apoptotic process; response to estradiol stimulus; response to ethanol; response to nutrient; response to oxidative stress; superoxide dismutase activity; superoxide metabolic process IPR003680; NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1) Nqo1 Dia4 Nmo1 Nmor1 Mus musculus (Mouse) TR25001_c1_g2_i1 Q5RD31 NQO1_PONAB 5.00E-90 GO:0003955; GO:0005737; GO:0043086; GO:0006979 NAD(P)H dehydrogenase (quinone) activity; cytoplasm; negative regulation of catalytic activity; response to oxidative stress IPR003680; NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1) NQO1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR25002_c1_g1_i1 Q8TBB0 THAP6_HUMAN 2.00E-08 GO:0003677; GO:0046872; GO:0015630 DNA binding; metal ion binding; microtubule cytoskeleton IPR026517; IPR006612; THAP domain-containing protein 6 THAP6 Homo sapiens (Human) TR25003_c1_g1_i2 Q8IZJ3 CPMD8_HUMAN 4.00E-19 GO:0005615; GO:0010951; GO:0005886; GO:0004867 extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR002350; IPR001599; IPR019742; IPR019565; IPR022041; IPR008930; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 CPAMD8 KIAA1283 Homo sapiens (Human) TR25004_c1_g1_i1 Q6DFC2 CCD77_XENLA 2.00E-163 Coiled-coil domain-containing protein 77 ccdc77 Xenopus laevis (African clawed frog) TR25005_c2_g1_i1 Q5F364 MRP1_CHICK 3.00E-09 GO:0005524; GO:0006200; GO:0042626; GO:0016021; GO:0005886 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; plasma membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP1 RCJMB04_32d20 Gallus gallus (Chicken) TR25006_c0_g1_i1 Q9BZE7 EVG1_HUMAN 4.00E-38 IPR007914; UPF0193 protein EVG1 C22orf23 Homo sapiens (Human) TR25008_c2_g1_i1 Q7TT28 REXO1_MOUSE 1.00E-140 GO:0004527; GO:0003676; GO:0090305; GO:0005634 exonuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis; nucleus IPR006055; IPR013520; IPR012337; RNA exonuclease 1 homolog (EC 3.1.-.-) (Transcription elongation factor B polypeptide 3-binding protein 1) Rexo1 Kiaa1138 Tceb3bp1 Mus musculus (Mouse) TR25010_c0_g1_i1 Q9D4C1 ILFT1_MOUSE 2.00E-13 GO:0008283; GO:0005737; GO:0005882; GO:0005635; GO:0005198 cell proliferation; cytoplasm; intermediate filament; nuclear envelope; structural molecule activity IPR001664; IPR001322; Intermediate filament tail domain-containing protein 1 (Lamin-A-related sequence 1 protein) Ifltd1 Lmna-rs1 Mus musculus (Mouse) TR25010_c1_g1_i1 Q04948 IFE_BRALA 4.00E-06 GO:0005737; GO:0005882; GO:0005198 cytoplasm; intermediate filament; structural molecule activity IPR001664; IPR018039; IPR002957; Non-neuronal cytoplasmic intermediate filament protein Branchiostoma lanceolatum (Common lancelet) (Amphioxus) TR25014_c2_g1_i1 Q704V6 TLR6_BOVIN 3.00E-06 GO:0002755; GO:0042088; GO:0042496; GO:0006954; GO:0045087; GO:0016021; GO:0030670; GO:0005886; GO:0045410; GO:0050707; GO:0034150; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; T-helper 1 type immune response; detection of diacyl bacterial lipopeptide; inflammatory response; innate immune response; integral to membrane; phagocytic vesicle membrane; plasma membrane; positive regulation of interleukin-6 biosynthetic process; regulation of cytokine secretion; toll-like receptor 6 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR000157; IPR027187; IPR017241; Toll-like receptor 6 (CD antigen CD286) TLR6 Bos taurus (Bovine) TR25021_c3_g1_i1 Q7Z407 CSMD3_HUMAN 1.00E-08 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 3 (CUB and sushi multiple domains protein 3) CSMD3 KIAA1894 Homo sapiens (Human) TR25025_c1_g1_i1 Q6NY73 L3BPB_DANRE 1.00E-19 GO:0007155; GO:0016020; GO:0005578; GO:0005044 cell adhesion; membrane; proteinaceous extracellular matrix; scavenger receptor activity IPR011705; IPR000210; IPR011333; IPR013069; IPR001190; IPR017448; Galectin-3-binding protein B (Lectin galactoside-binding soluble 3-binding protein B) lgals3bpb zgc:77059 Danio rerio (Zebrafish) (Brachydanio rerio) TR25025_c1_g2_i1 Q8WXS8 ATS14_HUMAN 2.00E-07 GO:0030574; GO:0030199; GO:0030198; GO:0005576; GO:0004222; GO:0005578; GO:0006508; GO:0008270 collagen catabolic process; collagen fibril organization; extracellular matrix organization; extracellular region; metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAM-TS 14) (ADAM-TS14) (ADAMTS-14) (EC 3.4.24.-) ADAMTS14 Homo sapiens (Human) TR25026_c0_g1_i1 Q96C45 ULK4_HUMAN 8.00E-48 GO:0005524; GO:0060271; GO:0003351; GO:0004674; GO:0021591 ATP binding; cilium morphogenesis; epithelial cilium movement; protein serine/threonine kinase activity; ventricular system development IPR011989; IPR016024; IPR011009; IPR000719; Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4) ULK4 Homo sapiens (Human) TR25028_c2_g1_i1 Q7Z2W4 ZCCHV_HUMAN 2.00E-12 GO:0005794; GO:0003950; GO:0003723; GO:0071360; GO:0005737; GO:0051607; GO:0045087; GO:0046872; GO:0045071; GO:0005634; GO:0005886; GO:0043123; GO:1900246; GO:0032727; GO:0032728; GO:0061014; GO:0032481; GO:0009615 O95786 Golgi apparatus; NAD+ ADP-ribosyltransferase activity; RNA binding; cellular response to exogenous dsRNA; cytoplasm; defense response to virus; innate immune response; metal ion binding; negative regulation of viral genome replication; nucleus; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of RIG-I signaling pathway; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of mRNA catabolic process; positive regulation of type I interferon production; response to virus IPR012317; IPR004170; IPR000571; Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) ZC3HAV1 ZC3HDC2 PRO1677 Homo sapiens (Human) TR25028_c2_g1_i3 Q8BZ20 PAR12_MOUSE 6.00E-24 GO:0003950; GO:0046872; GO:0005634 NAD+ ADP-ribosyltransferase activity; metal ion binding; nucleus IPR012317; IPR004170; IPR000571; Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) Parp12 Zc3hdc1 Mus musculus (Mouse) TR25030_c0_g1_i1 P86854 PLCL_MYTGA 2.00E-10 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR25032_c4_g1_i1 Q9GZU5 NYX_HUMAN 4.00E-12 GO:0005622; GO:0005578; GO:0050896; GO:0007601 intracellular; proteinaceous extracellular matrix; response to stimulus; visual perception IPR000483; IPR003591; IPR000372; Nyctalopin NYX CLRP Homo sapiens (Human) TR25033_c0_g2_i1 Q7ZWI4 GSKIP_DANRE 2.00E-18 GO:0005737 cytoplasm IPR007967; IPR023231; GSK3-beta interaction protein (GSKIP) gskip zgc:55683 Danio rerio (Zebrafish) (Brachydanio rerio) TR25036_c0_g1_i1 A0JM12 MEG10_XENTR 1.00E-06 GO:0007155; GO:0016021; GO:0006909; GO:0005886; GO:0014719; GO:0014816; GO:0014841 cell adhesion; integral to membrane; phagocytosis; plasma membrane; satellite cell activation; satellite cell differentiation; satellite cell proliferation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR25036_c0_g2_i1 P59222 SREC2_MOUSE 6.00E-08 GO:0007157; GO:0016021; GO:0005044 heterophilic cell-cell adhesion; integral to membrane; scavenger receptor activity IPR000742; IPR013032; IPR009030; Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) TR25036_c2_g1_i1 A4IFW2 PTPRF_DANRE 5.00E-31 GO:0007155; GO:0008201; GO:0016021; GO:0035335; GO:0004725; GO:0097374 cell adhesion; heparin binding; integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; sensory neuron axon guidance IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) ptprf si:dkey-21k10.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR25042_c1_g1_i2 Q9ULD5 ZN777_HUMAN 2.00E-11 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR022137; IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 777 ZNF777 KIAA1285 Homo sapiens (Human) TR25044_c0_g1_i1 Q91YN9 BAG2_MOUSE 1.00E-19 GO:0019538 protein metabolic process IPR003103; BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2) Bag2 Mus musculus (Mouse) TR25046_c0_g1_i1 G5E8K5 ANK3_MOUSE 1.00E-07 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR25047_c2_g1_i1 Q8TAM1 BBS10_HUMAN 5.00E-14 GO:0005524; GO:0044267; GO:0051131; GO:0005929; GO:0035058; GO:0045494; GO:0043254; GO:0050896; GO:0007601 Q6ZW61; Q8IWZ6; Q3SYG4 ATP binding; cellular protein metabolic process; chaperone-mediated protein complex assembly; cilium; nonmotile primary cilium assembly; photoreceptor cell maintenance; regulation of protein complex assembly; response to stimulus; visual perception IPR002423; IPR027413; Bardet-Biedl syndrome 10 protein BBS10 C12orf58 Homo sapiens (Human) TR25048_c0_g1_i1 Q8N0S6 CENPL_HUMAN 7.00E-14 GO:0000775; GO:0005829; GO:0000278; GO:0005634 "chromosome, centromeric region; cytosol; mitotic cell cycle; nucleus" IPR025204; Centromere protein L (CENP-L) (Interphase centromere complex protein 33) CENPL C1orf155 ICEN33 Homo sapiens (Human) TR25049_c0_g1_i1 Q28CH8 YIPF6_XENTR 2.00E-67 GO:0016021 integral to membrane IPR006977; Protein YIPF6 (YIP1 family member 6) yipf6 TGas105o14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR25049_c0_g1_i2 Q54RZ2 YIPF6_DICDI 5.00E-32 GO:0016021 integral to membrane IPR006977; Protein YIPF6 homolog yipf6 DDB_G0282825 Dictyostelium discoideum (Slime mold) TR2505_c0_g1_i1 Q12955 ANK3_HUMAN 4.00E-10 GO:0043001; GO:0030315; GO:0007411; GO:0043194; GO:0007409; GO:0016323; GO:0045296; GO:0009986; GO:0043034; GO:0014704; GO:0044325; GO:0016328; GO:0005764; GO:0072660; GO:0071709; GO:0000281; GO:0033268; GO:0033270; GO:0010628; GO:1900827; GO:0045838; GO:2000651; GO:0010765; GO:0045211; GO:0030674; GO:0072661; GO:0019228; GO:0043266; GO:0007165; GO:0030507; GO:0014731; GO:0005200; GO:0050808 "Golgi to plasma membrane protein transport; T-tubule; axon guidance; axon initial segment; axonogenesis; basolateral plasma membrane; cadherin binding; cell surface; costamere; intercalated disc; ion channel binding; lateral plasma membrane; lysosome; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; node of Ranvier; paranode region of axon; positive regulation of gene expression; positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; postsynaptic membrane; protein binding, bridging; protein targeting to plasma membrane; regulation of action potential in neuron; regulation of potassium ion transport; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton; synapse organization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) TR25051_c4_g2_i1 Q8BUP8 FA43A_MOUSE 4.00E-33 IPR011993 Protein FAM43A Fam43a Mus musculus (Mouse) TR25053_c0_g1_i2 Q92753 RORB_HUMAN 1.00E-23 GO:0042462; GO:0004879; GO:0005654; GO:0045893; GO:0043565; GO:0003707; GO:0006367; GO:0007601; GO:0008270 O08785 "eye photoreceptor cell development; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleoplasm; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; steroid hormone receptor activity; transcription initiation from RNA polymerase II promoter; visual perception; zinc ion binding" IPR008946; IPR000536; IPR003079; IPR001723; IPR001628; IPR013088; Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta) RORB NR1F2 RZRB Homo sapiens (Human) TR25054_c0_g1_i1 Q15050 RRS1_HUMAN 2.00E-75 GO:0000794; GO:0005783; GO:0007080; GO:0005730; GO:0042254 condensed nuclear chromosome; endoplasmic reticulum; mitotic metaphase plate congression; nucleolus; ribosome biogenesis IPR007023; Ribosome biogenesis regulatory protein homolog RRS1 KIAA0112 RRR Homo sapiens (Human) TR25054_c0_g1_i2 O59678 RRS1_SCHPO 6.00E-30 GO:0005730; GO:0006364 nucleolus; rRNA processing IPR007023; Ribosome biogenesis regulatory protein homolog SPBC29A3.16 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR25062_c0_g1_i1 Q9DAC7 TTC32_MOUSE 5.00E-26 IPR013026; IPR011990; IPR019734; Tetratricopeptide repeat protein 32 (TPR repeat protein 32) Ttc32 Mus musculus (Mouse) TR25068_c0_g1_i1 Q53GL7 PAR10_HUMAN 9.00E-30 GO:0005794; GO:0003950; GO:0048147; GO:0005634; GO:0070212; GO:0010847 Q9Y530 Golgi apparatus; NAD+ ADP-ribosyltransferase activity; negative regulation of fibroblast proliferation; nucleus; protein poly-ADP-ribosylation; regulation of chromatin assembly IPR012317; IPR003903; Poly [ADP-ribose] polymerase 10 (PARP-10) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) PARP10 Homo sapiens (Human) TR25070_c0_g1_i2 P62311 LSM3_MOUSE 2.00E-34 GO:0003723; GO:0008380; GO:0071013; GO:0006397 RNA binding; RNA splicing; catalytic step 2 spliceosome; mRNA processing IPR010920; IPR001163; IPR006649; U6 snRNA-associated Sm-like protein LSm3 Lsm3 Mus musculus (Mouse) TR25071_c0_g1_i1 Q9D074 MGRN1_MOUSE 4.00E-07 GO:0005769; GO:0045744; GO:0043951; GO:0005634; GO:0005886; GO:0000209; GO:0004842; GO:0008270 P04273 early endosome; negative regulation of G-protein coupled receptor protein signaling pathway; negative regulation of cAMP-mediated signaling; nucleus; plasma membrane; protein polyubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin RING finger protein 1) Mgrn1 Kiaa0544 Mus musculus (Mouse) TR25072_c2_g1_i3 Q99JT6 TLCD1_MOUSE 5.00E-20 GO:0016021 integral to membrane IPR006634; TLC domain-containing protein 1 Tlcd1 Mus musculus (Mouse) TR25073_c1_g1_i1 Q9Y6U7 RN215_HUMAN 6.00E-33 GO:0016021; GO:0008270 integral to membrane; zinc ion binding IPR001841; IPR013083; RING finger protein 215 RNF215 Homo sapiens (Human) TR25076_c0_g1_i1 Q6TV19 DICER_DANRE 4.00E-112 GO:0005524; GO:0008026; GO:0016442; GO:0005737; GO:0035279; GO:0046872; GO:0070883; GO:0031054; GO:0030422; GO:0004525; GO:0030423; GO:0021591 ATP binding; ATP-dependent helicase activity; RISC complex; cytoplasm; mRNA cleavage involved in gene silencing by miRNA; metal ion binding; pre-miRNA binding; pre-miRNA processing; production of siRNA involved in RNA interference; ribonuclease III activity; targeting of mRNA for destruction involved in RNA interference; ventricular system development IPR005034; IPR011545; IPR014720; IPR014001; IPR001650; IPR027417; IPR003100; IPR000999; Endoribonuclease Dicer (EC 3.1.26.-) dicer1 Danio rerio (Zebrafish) (Brachydanio rerio) TR2508_c0_g1_i1 P60755 MDGA2_MOUSE 3.00E-12 GO:0031225; GO:0007389; GO:0005886 anchored to membrane; pattern specification process; plasma membrane IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 2 (MAM domain-containing protein 1) Mdga2 Mamdc1 Mus musculus (Mouse) TR25080_c1_g1_i1 O43301 HS12A_HUMAN 3.00E-24 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR25081_c3_g1_i1 Q6PFY8 TRI45_MOUSE 6.00E-07 GO:0060348; GO:0005737; GO:0005634; GO:0008270 bone development; cytoplasm; nucleus; zinc ion binding IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) TR25081_c3_g1_i2 Q13263 TIF1B_HUMAN 5.00E-07 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR25081_c3_g1_i3 Q9H8W5 TRI45_HUMAN 4.00E-06 GO:0060348; GO:0005737; GO:0005634; GO:0008270 bone development; cytoplasm; nucleus; zinc ion binding IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) TR25088_c1_g1_i1 P06857 LIPR1_CANFA 2.00E-60 GO:0005509; GO:0003824; GO:0005576; GO:0016042 calcium ion binding; catalytic activity; extracellular region; lipid catabolic process IPR000734; IPR008976; IPR013818; IPR002331; IPR016272; IPR001024; Inactive pancreatic lipase-related protein 1 (PL-RP1) PNLIPRP1 PLRP1 Canis familiaris (Dog) (Canis lupus familiaris) TR25089_c1_g2_i1 Q9WUF2 EGR4_MOUSE 3.00E-09 GO:0003677; GO:0071320; GO:0071371; GO:0005737; GO:0046872; GO:0043066; GO:0005634; GO:0003700; GO:0006351 "DNA binding; cellular response to cAMP; cellular response to gonadotropin stimulus; cytoplasm; metal ion binding; negative regulation of apoptotic process; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Early growth response protein 4 (EGR-4) Egr4 Mus musculus (Mouse) TR25093_c2_g1_i1 O15020 SPTN2_HUMAN 8.00E-19 GO:0003779; GO:0051693; GO:0030534; GO:0019886; GO:0007411; GO:0008219; GO:0021692; GO:0005829; GO:0035264; GO:0043025; GO:0005543; GO:0008091; GO:0005200; GO:0007416; GO:0016192 actin binding; actin filament capping; adult behavior; antigen processing and presentation of exogenous peptide antigen via MHC class II; axon guidance; cell death; cerebellar Purkinje cell layer morphogenesis; cytosol; multicellular organism growth; neuronal cell body; phospholipid binding; spectrin; structural constituent of cytoskeleton; synapse assembly; vesicle-mediated transport IPR001589; IPR001715; IPR001605; IPR011993; IPR001849; IPR018159; IPR016343; IPR002017; "Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)" SPTBN2 KIAA0302 SCA5 Homo sapiens (Human) TR25093_c3_g1_i1 Q00963 SPTCB_DROME 8.00E-34 GO:0003779; GO:0051693; GO:0030506; GO:0016327; GO:0030424; GO:0016199; GO:0045169; GO:0045478; GO:0016328; GO:0005811; GO:0042062; GO:0048790; GO:0008017; GO:0007026; GO:0031594; GO:0007274; GO:0005546; GO:0072499; GO:0007009; GO:0008091; GO:0045170; GO:0030721; GO:0005200 "actin binding; actin filament capping; ankyrin binding; apicolateral plasma membrane; axon; axon midline choice point recognition; fusome; fusome organization; lateral plasma membrane; lipid particle; long-term strengthening of neuromuscular junction; maintenance of presynaptic active zone structure; microtubule binding; negative regulation of microtubule depolymerization; neuromuscular junction; neuromuscular synaptic transmission; phosphatidylinositol-4,5-bisphosphate binding; photoreceptor cell axon guidance; plasma membrane organization; spectrin; spectrosome; spectrosome organization; structural constituent of cytoskeleton" IPR001589; IPR001715; IPR001605; IPR011993; IPR001849; IPR018159; IPR016343; IPR002017; Spectrin beta chain beta-Spec Spec-b CG5870 Drosophila melanogaster (Fruit fly) TR25094_c0_g1_i1 Q5RA91 TAF11_PONAB 4.00E-51 GO:0043923; GO:0006355; GO:0003713; GO:0005669; GO:0006367 "positive regulation by host of viral transcription; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription factor TFIID complex; transcription initiation from RNA polymerase II promoter" IPR009072; IPR006809; Transcription initiation factor TFIID subunit 11 (TFIID subunit p30-beta) (Transcription initiation factor TFIID 28 kDa subunit) (TAF(II)28) (TAFII-28) (TAFII28) TAF11 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR25097_c2_g1_i1 Q502K3 ANR52_DANRE 8.00E-18 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) TR25097_c3_g1_i1 Q9WV71 ASB4_MOUSE 8.00E-07 GO:0031462; GO:0031466; GO:0035556; GO:2001214; GO:0051865; GO:0031625; GO:0004842 Cul2-RING ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex; intracellular signal transduction; positive regulation of vasculogenesis; protein autoubiquitination; ubiquitin protein ligase binding; ubiquitin-protein ligase activity IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 4 (ASB-4) Asb4 Mus musculus (Mouse) TR25097_c3_g1_i2 Q0VGY8 TANC1_MOUSE 1.00E-10 GO:0043679; GO:0030054; GO:0030425; GO:0097062; GO:0007520; GO:0043025; GO:0014069; GO:0045211; GO:0008542 axon terminus; cell junction; dendrite; dendritic spine maintenance; myoblast fusion; neuronal cell body; postsynaptic density; postsynaptic membrane; visual learning IPR002110; IPR020683; IPR027417; IPR013026; IPR011990; IPR013105; IPR019734; "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" Tanc1 Mus musculus (Mouse) TR25098_c1_g1_i1 Q684M4 KEAP1_PIG 2.00E-19 GO:0031463; GO:0005737; GO:0005634; GO:0010499; GO:0016567; GO:0006355; GO:0006351 "Cul3-RING ubiquitin ligase complex; cytoplasm; nucleus; proteasomal ubiquitin-independent protein catabolic process; protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) KEAP1 INRF2 Sus scrofa (Pig) TR25098_c1_g1_i2 A9JRD8 BTB6A_DANRE 6.00E-39 GO:0030154; GO:0000932; GO:0007399 cell differentiation; cytoplasmic mRNA processing body; nervous system development IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6-A btbd6a zgc:172197 Danio rerio (Zebrafish) (Brachydanio rerio) TR25101_c0_g1_i1 Q68FU5 CI085_RAT 5.00E-24 IPR019351; Uncharacterized protein C9orf85 homolog Rattus norvegicus (Rat) TR25108_c1_g2_i1 Q9P0M2 AKA7G_HUMAN 1.00E-25 GO:0016208; GO:0030315; GO:0016324; GO:0003824; GO:0005829; GO:0070382; GO:0008152; GO:0005634; GO:0043234; GO:0051018; GO:0010738; GO:0016529 AMP binding; T-tubule; apical plasma membrane; catalytic activity; cytosol; exocytic vesicle; metabolic process; nucleus; protein complex; protein kinase A binding; regulation of protein kinase A signaling cascade; sarcoplasmic reticulum IPR019510; IPR019511; IPR009097; A-kinase anchor protein 7 isoform gamma (AKAP-7 isoform gamma) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoform gamma) (PRKA7 isoform gamma) AKAP7 AKAP18 Homo sapiens (Human) TR25108_c1_g2_i2 Q6JP77 AKA7G_RAT 6.00E-24 GO:0016208; GO:0030315; GO:0016324; GO:0003824; GO:0005829; GO:0070382; GO:0008152; GO:0005634; GO:0043234; GO:0032947; GO:0034237; GO:0008104; GO:0010738; GO:0016529 P61016 AMP binding; T-tubule; apical plasma membrane; catalytic activity; cytosol; exocytic vesicle; metabolic process; nucleus; protein complex; protein complex scaffold; protein kinase A regulatory subunit binding; protein localization; regulation of protein kinase A signaling cascade; sarcoplasmic reticulum IPR019510; IPR019511; IPR009097; A-kinase anchor protein 7 isoforms delta and gamma (AKAP-7 isoforms delta and gamma) (A-kinase anchor protein 18) (AKAP-18) (Protein kinase A-anchoring protein 7 isoforms delta and gamma) (PRKA7 isoforms delta and gamma) Akap7 Akap18 Rattus norvegicus (Rat) TR25110_c1_g1_i1 Q148E0 CI021_BOVIN 3.00E-28 IPR012336; Thioredoxin-like protein AAED1 (AhpC/TSA antioxidant enzyme domain-containing protein 1) AAED1 Bos taurus (Bovine) TR25114_c0_g1_i1 Q54EM5 C519D_DICDI 7.00E-07 GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705 "heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Probable cytochrome P450 519D1 (EC 1.14.-.-) cyp519D1 DDB_G0291448 Dictyostelium discoideum (Slime mold) TR25114_c1_g1_i1 Q29496 CP3AO_SHEEP 5.00E-93 GO:0070330; GO:0005789; GO:0020037; GO:0005506; GO:0004497 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity IPR001128; IPR017972; IPR008072; IPR002402; Cytochrome P450 3A24 (EC 1.14.14.1) (CYPIIIA24) CYP3A24 Ovis aries (Sheep) TR25119_c1_g1_i1 Q5ZKK5 ODFP2_CHICK 6.00E-61 GO:0030154; GO:0005929; GO:0005737; GO:0005874; GO:0005815; GO:0007275; GO:0007283 cell differentiation; cilium; cytoplasm; microtubule; microtubule organizing center; multicellular organismal development; spermatogenesis IPR026099; Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) ODF2 RCJMB04_10e12 Gallus gallus (Chicken) TR25119_c1_g1_i3 Q4R8C3 ODFP2_MACFA 3.00E-44 GO:0030154; GO:0005814; GO:0005929; GO:0005874; GO:0007275; GO:0007283; GO:0000922 cell differentiation; centriole; cilium; microtubule; multicellular organismal development; spermatogenesis; spindle pole IPR026099; Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) ODF2 QtsA-12846 QtsA-13326 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR25119_c1_g2_i1 Q2MJU7 ODFP2_MESAU 1.00E-16 GO:0030154; GO:0005814; GO:0005929; GO:0005874; GO:0007275; GO:0007283; GO:0000922 cell differentiation; centriole; cilium; microtubule; multicellular organismal development; spermatogenesis; spindle pole IPR026099; Outer dense fiber protein 2 (84 kDa outer dense fiber protein) (Cenexin) (Outer dense fiber of sperm tails protein 2) (Fragment) ODF2 Mesocricetus auratus (Golden hamster) TR25122_c2_g1_i1 Q6JAN0 GPR98_DANRE 1.00E-09 GO:0004930; GO:0042462; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; eye photoreceptor cell development; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR003644; IPR008985; IPR013320; IPR009039; IPR017981; IPR000832; IPR026919; IPR000203; IPR001791; IPR003609; G-protein coupled receptor 98 (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) gpr98 mass1 vlgr1 Danio rerio (Zebrafish) (Brachydanio rerio) TR25122_c2_g2_i1 P16144 ITB4_HUMAN 3.00E-06 GO:0009925; GO:0005604; GO:0007155; GO:0031252; GO:0048870; GO:0009986; GO:0007160; GO:0030198; GO:0046847; GO:0030056; GO:0031581; GO:0008305; GO:0007229; GO:0007275; GO:0004872; GO:0009611 Q96B67; Q8R5M8-2; P23229; Q15149 basal plasma membrane; basement membrane; cell adhesion; cell leading edge; cell motility; cell surface; cell-matrix adhesion; extracellular matrix organization; filopodium assembly; hemidesmosome; hemidesmosome assembly; integrin complex; integrin-mediated signaling pathway; multicellular organismal development; receptor activity; response to wounding IPR003644; IPR013032; IPR013111; IPR003961; IPR013783; IPR015812; IPR012013; IPR002369; IPR012896; IPR016201; IPR002035; Integrin beta-4 (GP150) (CD antigen CD104) ITGB4 Homo sapiens (Human) TR25122_c3_g1_i1 P48768 NAC2_RAT 7.00E-09 GO:1990034; GO:1990035; GO:0060402; GO:0005432; GO:0007154; GO:0043197; GO:0016021; GO:0005874; GO:0005739; GO:0043025; GO:0005886; GO:0033280; GO:0021537 calcium ion export from cell; calcium ion import into cell; calcium ion transport into cytosol; calcium:sodium antiporter activity; cell communication; dendritic spine; integral to membrane; microtubule; mitochondrion; neuronal cell body; plasma membrane; response to vitamin D; telencephalon development IPR003644; IPR004836; IPR004837; Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2) Slc8a2 Ncx2 Rattus norvegicus (Rat) TR25124_c0_g1_i1 Q9HAS0 NJMU_HUMAN 4.00E-36 GO:0007283 spermatogenesis IPR028280; Protein Njmu-R1 C17orf75 Homo sapiens (Human) TR25126_c0_g1_i2 Q9WVT6 CAH14_MOUSE 5.00E-28 GO:0004089; GO:0016021; GO:0046872 carbonate dehydratase activity; integral to membrane; metal ion binding IPR018429; IPR001148; IPR023561; Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV) Ca14 Car14 Catm Mus musculus (Mouse) TR25128_c3_g1_i1 Q9QY06 MYO9B_MOUSE 2.00E-34 GO:0005524; GO:0005096; GO:0005100; GO:0007266; GO:0005938; GO:0030010; GO:0032433; GO:0035556; GO:0030027; GO:0072673; GO:0048246; GO:0046872; GO:0000146; GO:0002548; GO:0016459; GO:0048471; GO:0043547; GO:0001726 ATP binding; GTPase activator activity; Rho GTPase activator activity; Rho protein signal transduction; cell cortex; establishment of cell polarity; filopodium tip; intracellular signal transduction; lamellipodium; lamellipodium morphogenesis; macrophage chemotaxis; metal ion binding; microfilament motor activity; monocyte chemotaxis; myosin complex; perinuclear region of cytoplasm; positive regulation of GTPase activity; ruffle IPR000048; IPR001609; IPR027417; IPR002219; IPR000159; IPR008936; IPR000198; Unconventional myosin-IXb (Unconventional myosin-9b) Myo9b Myr5 Mus musculus (Mouse) TR25128_c3_g1_i2 B2RTY4 MYO9A_HUMAN 1.00E-37 GO:0005524; GO:0005096; GO:0005829; GO:0016021; GO:0046872; GO:0003774; GO:0043547; GO:0051056; GO:0007264; GO:0016461; GO:0007601 ATP binding; GTPase activator activity; cytosol; integral to membrane; metal ion binding; motor activity; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; unconventional myosin complex; visual perception IPR000048; IPR001609; IPR027417; IPR002219; IPR000159; IPR008936; IPR000198; Unconventional myosin-IXa (Unconventional myosin-9a) MYO9A MYR7 Homo sapiens (Human) TR25134_c1_g1_i1 Q03278 PO21_NASVI 2.00E-09 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR000477; IPR007087; IPR015880; Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 (Retrovirus-related Pol polyprotein from type I retrotransposable element R2) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] (Fragment) Nasonia vitripennis (Parasitic wasp) TR25134_c2_g1_i1 Q9NBX4 RTXE_DROME 3.00E-11 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR25137_c0_g1_i1 Q65AC2 S26A2_HORSE 3.00E-78 GO:0016021; GO:0008271; GO:0008272 integral to membrane; secondary active sulfate transmembrane transporter activity; sulfate transport IPR018045; IPR002645; IPR001902; IPR011547; Sulfate transporter (Solute carrier family 26 member 2) SLC26A2 Equus caballus (Horse) TR25144_c0_g1_i1 Q8BGS2 BOLA2_MOUSE 3.00E-23 IPR002634; BolA-like protein 2 Bola2 Mus musculus (Mouse) TR25144_c0_g1_i2 Q8CEI1 BOLA3_MOUSE 1.00E-07 GO:0005576 extracellular region IPR002634; BolA-like protein 3 Bola3 Mus musculus (Mouse) TR25146_c1_g1_i1 O35516 NOTC2_MOUSE 8.00E-20 GO:0007219; GO:0060413; GO:0005509; GO:0007050; GO:0001709; GO:0016049; GO:0009986; GO:0061073; GO:0005829; GO:0030326; GO:0005576; GO:0072104; GO:0072015; GO:0001947; GO:0006959; GO:0001701; GO:0002437; GO:0005887; GO:0072602; GO:0070986; GO:0002011; GO:0008285; GO:0000122; GO:0005654; GO:0060674; GO:0030513; GO:0046579; GO:0043065; GO:0008284; GO:0045672; GO:0072014; GO:0006351; GO:0042060 "Notch signaling pathway; atrial septum morphogenesis; calcium ion binding; cell cycle arrest; cell fate determination; cell growth; cell surface; ciliary body morphogenesis; cytosol; embryonic limb morphogenesis; extracellular region; glomerular capillary formation; glomerular visceral epithelial cell development; heart looping; humoral immune response; in utero embryonic development; inflammatory response to antigenic stimulus; integral to plasma membrane; interleukin-4 secretion; left/right axis specification; morphogenesis of an epithelial sheet; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; placenta blood vessel development; positive regulation of BMP signaling pathway; positive regulation of Ras protein signal transduction; positive regulation of apoptotic process; positive regulation of cell proliferation; positive regulation of osteoclast differentiation; proximal tubule development; transcription, DNA-dependent; wound healing" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022336; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 2 (Notch 2) (Motch B) [Cleaved into: Notch 2 extracellular truncation; Notch 2 intracellular domain] Notch2 Mus musculus (Mouse) TR25147_c1_g1_i2 A6H5Z3 EXC6B_MOUSE 1.00E-134 GO:0000145; GO:0006904 exocyst; vesicle docking involved in exocytosis IPR007225; Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2) Exoc6b Sec15b Sec15l2 Mus musculus (Mouse) TR25160_c0_g1_i1 P22674 CCNO_HUMAN 2.00E-35 GO:0007049; GO:0051301; GO:0045008; GO:0005654; GO:0000079; GO:0004844 cell cycle; cell division; depyrimidination; nucleoplasm; regulation of cyclin-dependent protein serine/threonine kinase activity; uracil DNA N-glycosylase activity IPR013763; IPR014400; IPR004367; IPR006671; Cyclin-O CCNO Homo sapiens (Human) TR25164_c0_g1_i2 Q9H0I3 CC113_HUMAN 7.00E-92 GO:0005737; GO:0005634; GO:0043234 cytoplasm; nucleus; protein complex IPR025254; Coiled-coil domain-containing protein 113 CCDC113 HSPC065 Homo sapiens (Human) TR25167_c0_g1_i1 Q9P1Z9 CI174_HUMAN 4.00E-33 GO:0016021 integral to membrane IPR028089; IPR027914; IPR026701; Coiled-coil domain-containing protein 180 CCDC180 C9orf174 KIAA1529 Homo sapiens (Human) TR25167_c1_g3_i1 Q9P1Z9 CI174_HUMAN 3.00E-11 GO:0016021 integral to membrane IPR028089; IPR027914; IPR026701; Coiled-coil domain-containing protein 180 CCDC180 C9orf174 KIAA1529 Homo sapiens (Human) TR25174_c0_g1_i1 Q17678 TIKI1_CAEEL 1.00E-07 GO:0016021; GO:0046872; GO:0008237; GO:0006508 integral to membrane; metal ion binding; metallopeptidase activity; proteolysis IPR002816; Metalloprotease TIKI homolog (EC 3.4.-.-) C05G5.5 Caenorhabditis elegans TR25174_c0_g2_i1 I1FQB6 TIKI1_AMPQE 1.00E-09 GO:0016021; GO:0046872; GO:0008237; GO:0006508 integral to membrane; metal ion binding; metallopeptidase activity; proteolysis IPR002816; Metalloprotease TIKI homolog (EC 3.4.-.-) Amphimedon queenslandica (Sponge) TR25174_c2_g1_i1 F6PTN1 TIKI1_XENTR 1.00E-32 GO:0016055; GO:0017147; GO:0060322; GO:0031301; GO:0005887; GO:0046872; GO:0004222; GO:0030178; GO:0018158; GO:0006508 Wnt receptor signaling pathway; Wnt-protein binding; head development; integral to organelle membrane; integral to plasma membrane; metal ion binding; metalloendopeptidase activity; negative regulation of Wnt receptor signaling pathway; protein oxidation; proteolysis IPR002816; Metalloprotease TIKI1 (EC 3.4.-.-) (TRAB domain-containing protein 2A) trabd2a tiki1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR25174_c2_g1_i2 B1ATG9 TIKI2_MOUSE 4.00E-50 GO:0016055; GO:0017147; GO:0031301; GO:0005887; GO:0046872; GO:0004222; GO:0030178; GO:0018158; GO:0006508 Wnt receptor signaling pathway; Wnt-protein binding; integral to organelle membrane; integral to plasma membrane; metal ion binding; metalloendopeptidase activity; negative regulation of Wnt receptor signaling pathway; protein oxidation; proteolysis IPR002816; "Metalloprotease TIKI2 (EC 3.4.-.-) (Heart, kidney and adipose-enriched transmembrane protein) (TRAB domain-containing protein 2B)" Trabd2b Gm12824 Hkat Tiki2 Mus musculus (Mouse) TR25174_c3_g1_i1 E7F6V0 TIKI1_DANRE 1.00E-43 GO:0016055; GO:0017147; GO:0060322; GO:0031301; GO:0005887; GO:0046872; GO:0004222; GO:0030178; GO:0018158; GO:0006508 Wnt receptor signaling pathway; Wnt-protein binding; head development; integral to organelle membrane; integral to plasma membrane; metal ion binding; metalloendopeptidase activity; negative regulation of Wnt receptor signaling pathway; protein oxidation; proteolysis IPR002816; Metalloprotease TIKI1 (EC 3.4.-.-) (TRAB domain-containing protein 2A) trabd2a tiki1 wu:fc66h01 Danio rerio (Zebrafish) (Brachydanio rerio) TR25179_c1_g1_i1 A5A761 SFXN1_PIG 6.00E-138 GO:0008324; GO:0030218; GO:0016021; GO:0055072; GO:0006826; GO:0005743 cation transmembrane transporter activity; erythrocyte differentiation; integral to membrane; iron ion homeostasis; iron ion transport; mitochondrial inner membrane IPR004686; Sideroflexin-1 SFXN1 Sus scrofa (Pig) TR2518_c0_g1_i1 B0JZG0 S23A2_XENTR 1.00E-19 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR006042; IPR006043; Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR25180_c0_g1_i1 Q626H5 PLX2_CAEBR 4.00E-18 GO:0030154; GO:0016021; GO:0005622; GO:0007275; GO:0005886; GO:0004872; GO:0007165 cell differentiation; integral to membrane; intracellular; multicellular organismal development; plasma membrane; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR008936; IPR001627; IPR015943; Plexin-2 plx-2 CBG00979 Caenorhabditis briggsae TR25180_c1_g1_i1 Q8CJH3 PLXB1_MOUSE 2.00E-24 GO:0005887; GO:0005622; GO:0033689; GO:0048812; GO:0043931; GO:0032321; GO:0050772; GO:0014068; GO:0008360; GO:0051493; GO:0017154; GO:0002116; GO:1900220 Q68FM7; Q8R4H2 integral to plasma membrane; intracellular; negative regulation of osteoblast proliferation; neuron projection morphogenesis; ossification involved in bone maturation; positive regulation of Rho GTPase activity; positive regulation of axonogenesis; positive regulation of phosphatidylinositol 3-kinase cascade; regulation of cell shape; regulation of cytoskeleton organization; semaphorin receptor activity; semaphorin receptor complex; semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-B1 Plxnb1 Kiaa0407 Mus musculus (Mouse) TR25184_c0_g1_i1 Q6DIB5 MEG10_MOUSE 4.00E-12 GO:0016323; GO:0042995; GO:0034109; GO:0016021; GO:0055001; GO:0001891; GO:0043654; GO:0051147; GO:0048641; GO:0014719; GO:0014816; GO:0014841 basolateral plasma membrane; cell projection; homotypic cell-cell adhesion; integral to membrane; muscle cell development; phagocytic cup; recognition of apoptotic cell; regulation of muscle cell differentiation; regulation of skeletal muscle tissue development; satellite cell activation; satellite cell differentiation; satellite cell proliferation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) TR25184_c0_g2_i1 Q06806 TIE1_MOUSE 1.00E-13 GO:0005524; GO:0001525; GO:0001701; GO:0016021; GO:0016525; GO:0030336; GO:0018108; GO:0005886; GO:0045026; GO:0032526; GO:0004714 ATP binding; angiogenesis; in utero embryonic development; integral to membrane; negative regulation of angiogenesis; negative regulation of cell migration; peptidyl-tyrosine phosphorylation; plasma membrane; plasma membrane fusion; response to retinoic acid; transmembrane receptor protein tyrosine kinase activity IPR000742; IPR013032; IPR003961; IPR007110; IPR013783; IPR003599; IPR013151; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) Tie1 Tie Tie-1 Mus musculus (Mouse) TR25186_c0_g1_i1 Q80TP3 UBR5_MOUSE 1.00E-14 GO:0006281; GO:0003723; GO:0005737; GO:2000780; GO:1901315; GO:0005634; GO:0050847; GO:0042787; GO:0006974; GO:0004842; GO:0008270 DNA repair; RNA binding; cytoplasm; negative regulation of double-strand break repair; negative regulation of histone H2A K63-linked ubiquitination; nucleus; progesterone receptor signaling pathway; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; response to DNA damage stimulus; ubiquitin-protein ligase activity; zinc ion binding IPR024725; IPR000569; IPR002004; IPR009091; IPR003126; IPR013993; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase UBR5 (EC 6.3.2.-) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog)" Ubr5 Edd Edd1 Kiaa0896 Mus musculus (Mouse) TR25186_c1_g1_i1 O95071 UBR5_HUMAN 3.00E-91 GO:0006281; GO:0003723; GO:0008283; GO:0005737; GO:2000780; GO:1901315; GO:0005634; GO:0090263; GO:0035413; GO:0033160; GO:0050847; GO:0000209; GO:0042787; GO:0006974; GO:0034450; GO:0008270 Q9BPZ3 "DNA repair; RNA binding; cell proliferation; cytoplasm; negative regulation of double-strand break repair; negative regulation of histone H2A K63-linked ubiquitination; nucleus; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of catenin import into nucleus; positive regulation of protein import into nucleus, translocation; progesterone receptor signaling pathway; protein polyubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; response to DNA damage stimulus; ubiquitin-ubiquitin ligase activity; zinc ion binding" IPR024725; IPR000569; IPR002004; IPR009091; IPR003126; IPR013993; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase UBR5 (EC 6.3.2.-) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)" UBR5 EDD EDD1 HYD KIAA0896 Homo sapiens (Human) TR25188_c1_g2_i1 Q8MH63 LAT1N_HUMAN 7.00E-14 GO:0015171; GO:0016021 amino acid transmembrane transporter activity; integral to membrane IPR002293; Putative L-type amino acid transporter 1-like protein MLAS (hLAT1 3-transmembrane protein MLAS) (hLAT1 3TM MLAS) SLC7A5P1 MLAS Homo sapiens (Human) TR25188_c2_g1_i1 Q9N1R6 BAT1_RABIT 1.00E-21 GO:0016021; GO:0015175; GO:0042605 integral to membrane; neutral amino acid transmembrane transporter activity; peptide antigen binding IPR002293; "B(0,+)-type amino acid transporter 1 (B(0,+)AT) (4F2-LC6) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)" SLC7A9 BAT1 Oryctolagus cuniculus (Rabbit) TR25189_c0_g1_i1 Q9VLM5 DAD1_DROME 6.00E-56 GO:0006915; GO:0004579; GO:0016021; GO:0008250; GO:0006486 apoptotic process; dolichyl-diphosphooligosaccharide-protein glycotransferase activity; integral to membrane; oligosaccharyltransferase complex; protein glycosylation IPR003038; Protein modification; protein glycosylation. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (DAD-1) (Defender against cell death 1) (Oligosaccharyl transferase subunit DAD1) (EC 2.4.99.18) CG13393 Drosophila melanogaster (Fruit fly) TR25191_c0_g3_i1 Q8WXK1 ASB15_HUMAN 1.00E-32 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 15 (ASB-15) ASB15 Homo sapiens (Human) TR25191_c0_g3_i2 Q08DV6 ASB3_BOVIN 2.00E-55 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 3 (ASB-3) ASB3 Bos taurus (Bovine) TR25191_c0_g3_i3 Q5F478 ANR44_CHICK 2.00E-27 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) TR25197_c0_g1_i1 Q6W8P9 AK1CO_HORSE 5.00E-64 GO:0005737; GO:0016491; GO:0008202 cytoplasm; oxidoreductase activity; steroid metabolic process IPR001395; IPR018170; IPR020471; IPR023210; Aldo-keto reductase family 1 member C23-like protein (EC 1.1.1.-) (Putative prostaglandin F synthase) PGFS Equus caballus (Horse) TR252_c1_g1_i1 Q9QYS2 GRM3_MOUSE 4.00E-14 GO:0030424; GO:0005246; GO:0043197; GO:0001641; GO:0016021; GO:0014069; GO:0045211; GO:0048786; GO:0042734; GO:0051930; GO:0019233; GO:0035249 "axon; calcium channel regulator activity; dendritic spine; group II metabotropic glutamate receptor activity; integral to membrane; postsynaptic density; postsynaptic membrane; presynaptic active zone; presynaptic membrane; regulation of sensory perception of pain; sensory perception of pain; synaptic transmission, glutamatergic" IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR000162; IPR001234; IPR028082; Metabotropic glutamate receptor 3 (mGluR3) Grm3 Gprc1c Mglur3 Mus musculus (Mouse) TR25202_c1_g1_i1 Q4UMH6 Y381_RICFE 1.00E-15 GO:0015969 guanosine tetraphosphate metabolic process IPR002110; IPR020683; IPR007685; Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR25205_c1_g1_i2 P34257 TC3A_CAEEL 5.00E-12 GO:0003677; GO:0015074; GO:0005634; GO:0004803; GO:0006313 "DNA binding; DNA integration; nucleus; transposase activity; transposition, DNA-mediated" IPR009057; IPR025898; IPR002492; Transposable element Tc3 transposase tc3a B0303.5 Caenorhabditis elegans TR25207_c3_g1_i1 P08021 FMRF_APLCA 2.00E-47 GO:0005576; GO:0007218 extracellular region; neuropeptide signaling pathway IPR002544; FMRF-amide neuropeptides [Cleaved into: FLRF-amide; FMRF-amide] Aplysia californica (California sea hare) TR25208_c1_g1_i1 Q6UZF7 RL35_HIPCM 2.00E-44 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001854; IPR018254; 60S ribosomal protein L35 rpl35 Hippocampus comes (Tiger tail seahorse) TR25212_c0_g1_i1 Q09225 NRF6_CAEEL 2.00E-37 GO:0016021; GO:0008289; GO:0006869; GO:0007275; GO:0016747 "integral to membrane; lipid binding; lipid transport; multicellular organismal development; transferase activity, transferring acyl groups other than amino-acyl groups" IPR002656; IPR006621; Nose resistant to fluoxetine protein 6 (Protein nrf-6) nrf-6 C08B11.4 Caenorhabditis elegans TR25217_c0_g2_i2 O13082 COX6A_CYPCA 1.00E-32 GO:0004129; GO:0005751 cytochrome-c oxidase activity; mitochondrial respiratory chain complex IV IPR001349; IPR018507; "Cytochrome c oxidase subunit 6A, mitochondrial (Cytochrome c oxidase polypeptide VIa)" Cyprinus carpio (Common carp) TR25220_c0_g1_i1 Q9BXX0 EMIL2_HUMAN 2.00E-06 GO:0007155; GO:0005581; GO:0030023; GO:0005576 cell adhesion; collagen; extracellular matrix constituent conferring elasticity; extracellular region IPR001073; IPR011489; IPR008983; EMILIN-2 (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10) EMILIN2 Homo sapiens (Human) TR25223_c2_g1_i1 Q9QZQ1 AFAD_MOUSE 2.00E-29 GO:0045177; GO:0007155; GO:0005913; GO:0005737; GO:0007165 apical part of cell; cell adhesion; cell-cell adherens junction; cytoplasm; signal transduction IPR018444; IPR002710; IPR000253; IPR001478; IPR000159; IPR008984; Afadin (Protein Af-6) Mllt4 Af6 Mus musculus (Mouse) TR25226_c0_g1_i1 P63245 GBLP_RAT 0 GO:0042169; GO:0007049; GO:0008656; GO:0005856; GO:0030425; GO:0007369; GO:0008200; GO:0030496; GO:0030178; GO:0030308; GO:0050765; GO:0051898; GO:0017148; GO:0043025; GO:0005634; GO:0043204; GO:0048471; GO:0001891; GO:0043547; GO:0043065; GO:0030335; GO:2000543; GO:2001244; GO:0032436; GO:0032464; GO:0001934; GO:0005080; GO:0007205; GO:0030292; GO:0030971; GO:0051726; GO:0051302; GO:2000114; GO:0090003; GO:0048511; GO:0015935 SH2 domain binding; cell cycle; cysteine-type endopeptidase activator activity involved in apoptotic process; cytoskeleton; dendrite; gastrulation; ion channel inhibitor activity; midbody; negative regulation of Wnt receptor signaling pathway; negative regulation of cell growth; negative regulation of phagocytosis; negative regulation of protein kinase B signaling cascade; negative regulation of translation; neuronal cell body; nucleus; perikaryon; perinuclear region of cytoplasm; phagocytic cup; positive regulation of GTPase activity; positive regulation of apoptotic process; positive regulation of cell migration; positive regulation of gastrulation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein homooligomerization; positive regulation of protein phosphorylation; protein kinase C binding; protein kinase C-activating G-protein coupled receptor signaling pathway; protein tyrosine kinase inhibitor activity; receptor tyrosine kinase binding; regulation of cell cycle; regulation of cell division; regulation of establishment of cell polarity; regulation of establishment of protein localization to plasma membrane; rhythmic process; small ribosomal subunit IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; "Guanine nucleotide-binding protein subunit beta-2-like 1 (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) (RACK1) [Cleaved into: Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed]" Gnb2l1 Rattus norvegicus (Rat) TR25231_c0_g1_i1 Q6PC69 RL10A_DANRE 7.00E-99 GO:0003723; GO:0015934; GO:0003735; GO:0006412 RNA binding; large ribosomal subunit; structural constituent of ribosome; translation IPR002143; IPR023674; IPR028364; IPR016094; IPR016095; IPR023673; 60S ribosomal protein L10a rpl10a zgc:73082 Danio rerio (Zebrafish) (Brachydanio rerio) TR25232_c0_g1_i1 Q54RA4 Y3291_DICDI 2.00E-19 GO:0005506; GO:0016706 "iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" IPR026992; IPR027443; IPR002283; IPR005123; Probable iron/ascorbate oxidoreductase DDB_G0283291 (EC 1.14.-.-) DDB_G0283291 Dictyostelium discoideum (Slime mold) TR25236_c0_g1_i1 Q9I927 FUCL5_ANGJA 8.00E-10 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-5 Anguilla japonica (Japanese eel) TR25236_c0_g1_i4 Q7SIC1 FUCL_ANGAN 2.00E-08 GO:0005509; GO:0007155; GO:0005576; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular region; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin Anguilla anguilla (European freshwater eel) (Muraena anguilla) TR25237_c2_g1_i1 Q9NYL5 CP39A_HUMAN 2.00E-48 GO:0033782; GO:0006699; GO:0030573; GO:0006707; GO:0007586; GO:0005789; GO:0020037; GO:0005506; GO:0008396; GO:0008387; GO:0016125; GO:0006805 24-hydroxycholesterol 7alpha-hydroxylase activity; bile acid biosynthetic process; bile acid catabolic process; cholesterol catabolic process; digestion; endoplasmic reticulum membrane; heme binding; iron ion binding; oxysterol 7-alpha-hydroxylase activity; steroid 7-alpha-hydroxylase activity; sterol metabolic process; xenobiotic metabolic process IPR001128; IPR024204; IPR002403; 24-hydroxycholesterol 7-alpha-hydroxylase (EC 1.14.13.99) (Cytochrome P450 39A1) (hCYP39A1) (Oxysterol 7-alpha-hydroxylase) CYP39A1 Homo sapiens (Human) TR25241_c1_g1_i1 Q21389 LGE1_CAEEL 6.00E-23 GO:0000139; GO:0016021; GO:0016757 "Golgi membrane; integral to membrane; transferase activity, transferring glycosyl groups" IPR002495; Glycosyltransferase-like protein LARGE (EC 2.4.-.-) lge-1 K09C8.4 Caenorhabditis elegans TR25241_c4_g1_i1 Q66PG1 LARG2_DANRE 2.00E-74 GO:0005794; GO:0000139; GO:0016021; GO:0006486; GO:0016757 "Golgi apparatus; Golgi membrane; integral to membrane; protein glycosylation; transferase activity, transferring glycosyl groups" IPR002495; Glycosyltransferase-like protein LARGE2 (EC 2.4.-.-) (Glycosyltransferase-like 1B) gyltl1b large2 si:ch211-206g24.1 si:ch211-282n12.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR25249_c0_g1_i2 A7MCB7 TMA16_DANRE 1.00E-39 IPR021346; Translation machinery-associated protein 16 tma16 zgc:110664 Danio rerio (Zebrafish) (Brachydanio rerio) TR25249_c0_g1_i3 A7MCB7 TMA16_DANRE 3.00E-39 IPR021346; Translation machinery-associated protein 16 tma16 zgc:110664 Danio rerio (Zebrafish) (Brachydanio rerio) TR25252_c0_g1_i2 A8E4S7 MB213_DANRE 5.00E-07 IPR024810; Protein mab-21-like 3 mab21L3 si:ch211-246m4.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR25253_c1_g1_i1 Q6NTS2 BAFA_XENLA 2.00E-44 GO:0003677; GO:0005694; GO:0005634 DNA binding; chromosome; nucleus IPR004122; Barrier-to-autointegration factor A banf1-a baf-a Xenopus laevis (African clawed frog) TR25254_c1_g1_i1 Q14517 FAT1_HUMAN 3.00E-14 GO:0007015; GO:0009653; GO:0005509; GO:0016477; GO:0016337; GO:0005911; GO:0007267; GO:0007163; GO:0030175; GO:0007156; GO:0005887; GO:0030027; GO:0005634; GO:0048471 Q8N8S7; Q9NSC5; Q99JP6 actin filament organization; anatomical structure morphogenesis; calcium ion binding; cell migration; cell-cell adhesion; cell-cell junction; cell-cell signaling; establishment or maintenance of cell polarity; filopodium; homophilic cell adhesion; integral to plasma membrane; lamellipodium; nucleus; perinuclear region of cytoplasm IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) TR25254_c3_g1_i1 Q96TA0 PCDBI_HUMAN 2.00E-13 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR013164; Putative protocadherin beta-18 (PCDH-beta-18) (PCDH-psi2) PCDHB18 Homo sapiens (Human) TR25254_c4_g1_i1 Q24292 DS_DROME 4.00E-21 GO:0005509; GO:0016339; GO:0050839; GO:0000904; GO:0008283; GO:0045317; GO:0045198; GO:0001737; GO:0007156; GO:0007480; GO:0005887; GO:0090176; GO:0016318; GO:0018149; GO:0004872; GO:0090175; GO:0035159; GO:0004871; GO:0035222 "calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; cell morphogenesis involved in differentiation; cell proliferation; equator specification; establishment of epithelial cell apical/basal polarity; establishment of imaginal disc-derived wing hair orientation; homophilic cell adhesion; imaginal disc-derived leg morphogenesis; integral to plasma membrane; microtubule cytoskeleton organization involved in establishment of planar polarity; ommatidial rotation; peptide cross-linking; receptor activity; regulation of establishment of planar polarity; regulation of tube length, open tracheal system; signal transducer activity; wing disc pattern formation" IPR002126; IPR015919; IPR020894; IPR000233; Protein dachsous (Adherin) ds CG17941 Drosophila melanogaster (Fruit fly) TR25254_c4_g2_i1 Q96JQ0 PCD16_HUMAN 1.00E-15 GO:0005509; GO:0016339; GO:0007156; GO:0016021; GO:0016020; GO:0005886 calcium ion binding; calcium-dependent cell-cell adhesion; homophilic cell adhesion; integral to membrane; membrane; plasma membrane IPR002126; IPR015919; IPR020894; Protocadherin-16 (Cadherin-19) (Cadherin-25) (Fibroblast cadherin-1) (Protein dachsous homolog 1) DCHS1 CDH19 CDH25 FIB1 KIAA1773 PCDH16 Homo sapiens (Human) TR25258_c0_g1_i1 A7RWD2 CIAO1_NEMVE 3.00E-168 GO:0016226 iron-sulfur cluster assembly IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog v1g226592 Nematostella vectensis (Starlet sea anemone) TR25258_c0_g1_i2 Q9GL51 LIS1_PIG 6.00E-26 GO:0030154; GO:0051301; GO:0006928; GO:0005737; GO:0000132; GO:0016042; GO:0005874; GO:0005875; GO:0005815; GO:0007067; GO:0007399; GO:0031965; GO:0005819; GO:0006810 cell differentiation; cell division; cellular component movement; cytoplasm; establishment of mitotic spindle orientation; lipid catabolic process; microtubule; microtubule associated complex; microtubule organizing center; mitosis; nervous system development; nuclear membrane; spindle; transport IPR017252; IPR020472; IPR006594; IPR013720; IPR015943; IPR001680; IPR019775; IPR017986; Platelet-activating factor acetylhydrolase IB subunit alpha (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) PAFAH1B1 LIS1 PAFAHA Sus scrofa (Pig) TR25262_c1_g1_i1 Q496A3 SPAS1_HUMAN 3.00E-21 Spermatogenesis-associated serine-rich protein 1 SPATS1 Homo sapiens (Human) TR25263_c0_g1_i1 Q5XG73 ACBD5_MOUSE 1.00E-29 GO:0000062; GO:0016021; GO:0008289; GO:0005778; GO:0006810 fatty-acyl-CoA binding; integral to membrane; lipid binding; peroxisomal membrane; transport IPR022408; IPR000582; IPR014352; IPR016347; Acyl-CoA-binding domain-containing protein 5 Acbd5 Mus musculus (Mouse) TR25267_c1_g1_i1 D2GXS7 TRIM2_AILME 8.00E-06 GO:0005737; GO:0043523; GO:0004842; GO:0008270 cytoplasm; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) TR25272_c0_g1_i1 Q9MZD2 FLNB_RABIT 3.00E-30 GO:0005938; GO:0005856 cell cortex; cytoskeleton IPR001298; IPR017868; IPR013783; IPR014756; Filamin-B (FLN-B) (ABP-280-like protein) (Actin-binding-like protein) (Beta-filamin) (C254) (Fragment) FLNB Oryctolagus cuniculus (Rabbit) TR25277_c1_g1_i2 Q7T330 SPOP_DANRE 3.00E-14 GO:0031463; GO:0016607; GO:0005634; GO:0043161; GO:0016567 Cul3-RING ubiquitin ligase complex; nuclear speck; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination IPR000210; IPR011333; IPR013069; IPR002083; IPR008974; Protein modification; protein ubiquitination. Speckle-type POZ protein (HIB homolog 1) (SPOP1) spop zgc:64140 Danio rerio (Zebrafish) (Brachydanio rerio) TR25277_c1_g1_i3 Q5TZE1 BTB6B_DANRE 5.00E-28 GO:0030154; GO:0000932; GO:0007399 cell differentiation; cytoplasmic mRNA processing body; nervous system development IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6-B btbd6b btbd6 si:dkey-11b8.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR25278_c1_g1_i1 Q5XHM7 CHSTC_XENLA 9.00E-07 GO:0000139; GO:0016051; GO:0047756; GO:0016021 Golgi membrane; carbohydrate biosynthetic process; chondroitin 4-sulfotransferase activity; integral to membrane IPR018011; IPR005331; Carbohydrate sulfotransferase 12 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 2) (Chondroitin 4-sulfotransferase 2) (C4ST-2) (C4ST2) chst12 Xenopus laevis (African clawed frog) TR25278_c2_g1_i1 P69478 CHSTB_RAT 1.00E-16 GO:0000139; GO:0001537; GO:0050659; GO:0016051; GO:0002063; GO:0047756; GO:0030206; GO:0048589; GO:0042733; GO:0048703; GO:0016021; GO:0043066; GO:0030512; GO:0033037; GO:0036342; GO:0009791; GO:0042127; GO:0007585 Golgi membrane; N-acetylgalactosamine 4-O-sulfotransferase activity; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity; carbohydrate biosynthetic process; chondrocyte development; chondroitin 4-sulfotransferase activity; chondroitin sulfate biosynthetic process; developmental growth; embryonic digit morphogenesis; embryonic viscerocranium morphogenesis; integral to membrane; negative regulation of apoptotic process; negative regulation of transforming growth factor beta receptor signaling pathway; polysaccharide localization; post-anal tail morphogenesis; post-embryonic development; regulation of cell proliferation; respiratory gaseous exchange IPR018011; IPR005331; Carbohydrate sulfotransferase 11 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 1) (Chondroitin 4-sulfotransferase 1) (C4S-1) (C4ST-1) (C4ST1) Chst11 Rattus norvegicus (Rat) TR2528_c0_g1_i1 P18172 DHGL_DROPS 2.00E-13 GO:0006066; GO:0008812; GO:0005576; GO:0050660 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR25280_c2_g1_i1 P48066 S6A11_HUMAN 3.00E-09 GO:0007420; GO:0042995; GO:0005737; GO:0005332; GO:0016021; GO:0005887; GO:0042165; GO:0007269; GO:0005328; GO:0005886; GO:0042493; GO:0055085 brain development; cell projection; cytoplasm; gamma-aminobutyric acid:sodium symporter activity; integral to membrane; integral to plasma membrane; neurotransmitter binding; neurotransmitter secretion; neurotransmitter:sodium symporter activity; plasma membrane; response to drug; transmembrane transport IPR000175; IPR002982; Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11) SLC6A11 GABT3 GAT3 Homo sapiens (Human) TR25281_c0_g1_i1 E7EYQ9 TM216_DANRE 4.00E-23 GO:0042384; GO:0005737; GO:0016021; GO:0005932 cilium assembly; cytoplasm; integral to membrane; microtubule basal body IPR019184; Transmembrane protein 216 tmem216 Danio rerio (Zebrafish) (Brachydanio rerio) TR25282_c2_g1_i1 Q9JLC8 SACS_MOUSE 5.00E-13 GO:0005524; GO:0050750; GO:0005739; GO:0090084; GO:0005634 ATP binding; low-density lipoprotein particle receptor binding; mitochondrion; negative regulation of inclusion body assembly; nucleus IPR001623; IPR003594; IPR007842; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) TR25283_c0_g1_i2 P90978 U2AF2_CAEEL 1.00E-63 GO:0048589; GO:0010172; GO:0007281; GO:0000398; GO:0002119; GO:0005654; GO:0000166; GO:0030628; GO:0005681 "developmental growth; embryonic body morphogenesis; germ cell development; mRNA splicing, via spliceosome; nematode larval development; nucleoplasm; nucleotide binding; pre-mRNA 3'-splice site binding; spliceosomal complex" IPR012677; IPR000504; IPR006529; Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (U2AF65) (U2 snRNP auxiliary factor large subunit) uaf-1 Y92C3B.2 Caenorhabditis elegans TR25283_c0_g1_i3 Q63285 UHMK1_RAT 4.00E-07 GO:0005524; GO:0003723; GO:0030424; GO:0007050; GO:0005737; GO:0032839; GO:0031175; GO:0071598; GO:0005634; GO:0018105; GO:0045948; GO:0046777; GO:0004674; GO:0046825; GO:0043021 ATP binding; RNA binding; axon; cell cycle arrest; cytoplasm; dendrite cytoplasm; neuron projection development; neuronal ribonucleoprotein granule; nucleus; peptidyl-serine phosphorylation; positive regulation of translational initiation; protein autophosphorylation; protein serine/threonine kinase activity; regulation of protein export from nucleus; ribonucleoprotein complex binding IPR011009; IPR012677; IPR000719; IPR000504; Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (PAM COOH-terminal interactor protein 2) (P-CIP2) (U2AF homology motif kinase 1) Uhmk1 Kis Kist Rattus norvegicus (Rat) TR25283_c0_g1_i4 Q24562 U2AF2_DROME 1.00E-84 GO:0005686; GO:0003729; GO:0000398; GO:0007052; GO:0022008; GO:0051168; GO:0000166; GO:0008187; GO:0071011; GO:0000381 "U2 snRNP; mRNA binding; mRNA splicing, via spliceosome; mitotic spindle organization; neurogenesis; nuclear export; nucleotide binding; poly-pyrimidine tract binding; precatalytic spliceosome; regulation of alternative mRNA splicing, via spliceosome" IPR012677; IPR000504; IPR006529; Splicing factor U2AF 50 kDa subunit (U2 auxiliary factor 50 kDa subunit) (U2 snRNP auxiliary factor large subunit) U2af50 CG9998 Drosophila melanogaster (Fruit fly) TR25283_c0_g1_i5 Q24562 U2AF2_DROME 0 GO:0005686; GO:0003729; GO:0000398; GO:0007052; GO:0022008; GO:0051168; GO:0000166; GO:0008187; GO:0071011; GO:0000381 "U2 snRNP; mRNA binding; mRNA splicing, via spliceosome; mitotic spindle organization; neurogenesis; nuclear export; nucleotide binding; poly-pyrimidine tract binding; precatalytic spliceosome; regulation of alternative mRNA splicing, via spliceosome" IPR012677; IPR000504; IPR006529; Splicing factor U2AF 50 kDa subunit (U2 auxiliary factor 50 kDa subunit) (U2 snRNP auxiliary factor large subunit) U2af50 CG9998 Drosophila melanogaster (Fruit fly) TR25288_c1_g1_i1 Q61792 LASP1_MOUSE 2.00E-39 GO:0051015; GO:0030864; GO:0005925; GO:0015075; GO:0008270 actin filament binding; cortical actin cytoskeleton; focal adhesion; ion transmembrane transporter activity; zinc ion binding IPR000900; IPR001452; IPR001781; LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) Lasp1 Mln50 Mus musculus (Mouse) TR25288_c1_g1_i2 Q61792 LASP1_MOUSE 1.00E-39 GO:0051015; GO:0030864; GO:0005925; GO:0015075; GO:0008270 actin filament binding; cortical actin cytoskeleton; focal adhesion; ion transmembrane transporter activity; zinc ion binding IPR000900; IPR001452; IPR001781; LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) Lasp1 Mln50 Mus musculus (Mouse) TR25291_c0_g1_i1 Q03601 NHL1_CAEEL 3.00E-10 GO:0008270 G5EFS1; O62482 zinc ion binding IPR011042; IPR001258; IPR013017; IPR018957; IPR001841; IPR013083; IPR017907; RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans TR25293_c0_g1_i2 Q9W3T5 U640_DROME 2.00E-09 GO:0016021 Q9VYJ4 integral to membrane IPR028183; Small integral membrane protein 4 CG32736 Drosophila melanogaster (Fruit fly) TR25296_c5_g1_i2 O15078 CE290_HUMAN 2.00E-26 GO:0000086; GO:0036038; GO:0009986; GO:0005813; GO:0042384; GO:0005829; GO:0007163; GO:0042462; GO:0030902; GO:0005932; GO:0005634; GO:0030916; GO:0032391; GO:0045893; GO:0048793; GO:0015031; GO:0030814; GO:0060041 Q2M1K9 "G2/M transition of mitotic cell cycle; TCTN-B9D complex; cell surface; centrosome; cilium assembly; cytosol; establishment or maintenance of cell polarity; eye photoreceptor cell development; hindbrain development; microtubule basal body; nucleus; otic vesicle formation; photoreceptor connecting cilium; positive regulation of transcription, DNA-dependent; pronephros development; protein transport; regulation of cAMP metabolic process; retina development in camera-type eye" IPR026201; Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2) CEP290 BBS14 KIAA0373 NPHP6 Homo sapiens (Human) TR25296_c6_g1_i1 Q9TU23 CE290_BOVIN 7.00E-29 GO:0036038; GO:0005813; GO:0060271; GO:0005829; GO:0005932; GO:0005634; GO:0032391; GO:0045893; GO:0015031 "TCTN-B9D complex; centrosome; cilium morphogenesis; cytosol; microtubule basal body; nucleus; photoreceptor connecting cilium; positive regulation of transcription, DNA-dependent; protein transport" IPR026201; Centrosomal protein of 290 kDa (Cep290) (Nephrocystin-6) (Fragment) CEP290 NPHP6 Bos taurus (Bovine) TR25297_c3_g1_i1 P50393 PA24A_RAT 1.00E-36 GO:0007568; GO:0019369; GO:0005509; GO:0047498; GO:0005544; GO:0005829; GO:0046697; GO:0001554; GO:0004622; GO:0005634; GO:0001542; GO:0048471; GO:0009395; GO:0043065; GO:0030501; GO:0008284; GO:0031622; GO:0031394; GO:0031340; GO:0051592; GO:0051384; GO:0009408; GO:0042542; GO:0032496; GO:0051597; GO:0010243; GO:0033280; GO:0043129; GO:0042588 aging; arachidonic acid metabolic process; calcium ion binding; calcium-dependent phospholipase A2 activity; calcium-dependent phospholipid binding; cytosol; decidualization; luteolysis; lysophospholipase activity; nucleus; ovulation from ovarian follicle; perinuclear region of cytoplasm; phospholipid catabolic process; positive regulation of apoptotic process; positive regulation of bone mineralization; positive regulation of cell proliferation; positive regulation of fever generation; positive regulation of prostaglandin biosynthetic process; positive regulation of vesicle fusion; response to calcium ion; response to glucocorticoid stimulus; response to heat; response to hydrogen peroxide; response to lipopolysaccharide; response to methylmercury; response to organonitrogen compound; response to vitamin D; surfactant homeostasis; zymogen granule IPR016035; IPR000008; IPR002642; Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] Pla2g4a Cpla2 Pla2g4 Rattus norvegicus (Rat) TR25302_c0_g1_i1 P82103 MYNA_MYTGA 5.00E-12 GO:0042742; GO:0005576 defense response to bacterium; extracellular region IPR019631; Myticin-A Mytilus galloprovincialis (Mediterranean mussel) TR25303_c0_g1_i1 Q502M6 ANR29_DANRE 4.00E-22 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) TR25304_c0_g1_i2 P27080 ADT_CHLRE 2.00E-111 GO:0016021; GO:0005743; GO:0055085; GO:0005215 integral to membrane; mitochondrial inner membrane; transmembrane transport; transporter activity IPR002113; IPR002067; IPR018108; IPR023395; "ADP,ATP carrier protein (ADP/ATP translocase) (Adenine nucleotide translocator) (ANT)" ABT Chlamydomonas reinhardtii (Chlamydomonas smithii) TR25305_c0_g1_i2 O60762 DPM1_HUMAN 1.00E-121 GO:0006501; GO:0019673; GO:0006506; GO:0043178; GO:0019348; GO:0006488; GO:0033185; GO:0004582; GO:0004169; GO:0005789; GO:0005537; GO:0018279; GO:0035269 C-terminal protein lipidation; GDP-mannose metabolic process; GPI anchor biosynthetic process; alcohol binding; dolichol metabolic process; dolichol-linked oligosaccharide biosynthetic process; dolichol-phosphate-mannose synthase complex; dolichyl-phosphate beta-D-mannosyltransferase activity; dolichyl-phosphate-mannose-protein mannosyltransferase activity; endoplasmic reticulum membrane; mannose binding; protein N-linked glycosylation via asparagine; protein O-linked mannosylation IPR001173; Protein modification; protein glycosylation. Dolichol-phosphate mannosyltransferase (EC 2.4.1.83) (Dolichol-phosphate mannose synthase) (DPM synthase) (Dolichyl-phosphate beta-D-mannosyltransferase) (Mannose-P-dolichol synthase) (MPD synthase) DPM1 Homo sapiens (Human) TR25306_c0_g1_i2 P87304 YB22_SCHPO 1.00E-12 GO:0047617; GO:0006637; GO:0005829; GO:0006631; GO:0005634 acyl-CoA hydrolase activity; acyl-CoA metabolic process; cytosol; fatty acid metabolic process; nucleus IPR006683; Putative esterase C31F10.02 (EC 3.1.2.-) SPBC31F10.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR25306_c0_g1_i3 Q5R833 ACO13_PONAB 3.00E-18 GO:0016787; GO:0005739 hydrolase activity; mitochondrion IPR003736; IPR006683; "Acyl-coenzyme A thioesterase 13 (Acyl-CoA thioesterase 13) (EC 3.1.2.-) (Thioesterase superfamily member 2) [Cleaved into: Acyl-coenzyme A thioesterase 13, N-terminally processed]" ACOT13 THEM2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR25306_c0_g1_i4 O28020 Y2264_ARCFU 3.00E-06 GO:0016790 thiolester hydrolase activity IPR011973; IPR003736; IPR006683; Putative esterase AF_2264 (EC 3.1.2.-) AF_2264 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) TR25307_c3_g1_i1 P86177 CSL1_ONCKE 2.00E-10 GO:0030246 carbohydrate binding IPR000922; L-rhamnose-binding lectin CSL1 Oncorhynchus keta (Chum salmon) (Salmo keta) TR25309_c3_g1_i2 P02637 SCP_MIZYE 1.00E-07 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Sarcoplasmic calcium-binding protein (SCP) Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) TR25316_c0_g1_i1 Q9UBG0 MRC2_HUMAN 4.00E-08 GO:0030246; GO:0006897; GO:0016021 carbohydrate binding; endocytosis; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; C-type mannose receptor 2 (C-type lectin domain family 13 member E) (Endocytic receptor 180) (Macrophage mannose receptor 2) (Urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (Urokinase receptor-associated protein) (CD antigen CD280) MRC2 CLEC13E ENDO180 KIAA0709 UPARAP Homo sapiens (Human) TR25316_c0_g1_i2 Q66S61 MBL2_CALJA 2.00E-08 GO:0005581; GO:0006958; GO:0001867; GO:0005537 "collagen; complement activation, classical pathway; complement activation, lectin pathway; mannose binding" IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Mannose-binding protein C (MBP-C) (MBP1) (Mannan-binding protein) (Mannose-binding lectin) MBL2 Callithrix jacchus (White-tufted-ear marmoset) TR25316_c0_g1_i3 P20693 FCER2_MOUSE 2.00E-14 GO:0030246; GO:0009897; GO:0016021; GO:0046872; GO:0002925; GO:0051712; GO:0051000; GO:0051770 carbohydrate binding; external side of plasma membrane; integral to membrane; metal ion binding; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of killing of cells of other organism; positive regulation of nitric-oxide synthase activity; positive regulation of nitric-oxide synthase biosynthetic process IPR001304; IPR016186; IPR018378; IPR016187; Low affinity immunoglobulin epsilon Fc receptor (Fc-epsilon-RII) (Lymphocyte IgE receptor) (CD antigen CD23) Fcer2 Fcer2a Mus musculus (Mouse) TR25321_c1_g1_i1 P30122 CEL_BOVIN 5.00E-27 GO:0047372; GO:0004091; GO:0005829; GO:0005615; GO:0016042; GO:0004771; GO:0004806 acylglycerol lipase activity; carboxylesterase activity; cytosol; extracellular space; lipid catabolic process; sterol esterase activity; triglyceride lipase activity IPR002018; IPR019826; IPR019819; Bile salt-activated lipase (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Cholesterol esterase) (Pancreatic lysophospholipase) (Sterol esterase) (Fragment) CEL Bos taurus (Bovine) TR25321_c1_g2_i1 Q04791 SASB_ANAPL 9.00E-24 GO:0006633; GO:0016787 fatty acid biosynthetic process; hydrolase activity IPR002018; IPR019826; IPR019819; "Fatty acyl-CoA hydrolase precursor, medium chain (EC 3.1.2.-) (Thioesterase B)" Anas platyrhynchos (Domestic duck) (Anas boschas) TR25321_c2_g2_i1 Q8NFZ3 NLGNY_HUMAN 3.00E-25 GO:0007155; GO:0030054; GO:0009986; GO:0005887; GO:0042043; GO:0014069; GO:0045211; GO:0004872; GO:0045202; GO:0007416 cell adhesion; cell junction; cell surface; integral to plasma membrane; neurexin family protein binding; postsynaptic density; postsynaptic membrane; receptor activity; synapse; synapse assembly IPR002018; IPR019819; IPR000460; "Neuroligin-4, Y-linked (Neuroligin Y)" NLGN4Y KIAA0951 Homo sapiens (Human) TR25322_c0_g1_i2 P79171 AMPN_FELCA 7.00E-07 GO:0004177; GO:0001525; GO:0030154; GO:0016021; GO:0008237; GO:0019048; GO:0006508; GO:0009615; GO:0001618; GO:0008270 aminopeptidase activity; angiogenesis; cell differentiation; integral to membrane; metallopeptidase activity; modulation by virus of host morphology or physiology; proteolysis; response to virus; virus receptor activity; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (AP-N) (fAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) ANPEP APN Felis catus (Cat) (Felis silvestris catus) TR25323_c0_g1_i1 Q63769 SRPX_RAT 3.00E-10 GO:0005776; GO:0006914; GO:0009986; GO:0033554; GO:0005783; GO:0060244; GO:0001845; GO:0043065 autophagic vacuole; autophagy; cell surface; cellular response to stress; endoplasmic reticulum; negative regulation of cell proliferation involved in contact inhibition; phagolysosome assembly; positive regulation of apoptotic process IPR025232; IPR003410; IPR000436; Sushi repeat-containing protein SRPX (Down-regulated by v-SRC) (DRS) Srpx Drs Rattus norvegicus (Rat) TR25323_c0_g1_i2 Q501P1 FBLN7_MOUSE 4.00E-07 GO:0005509; GO:0007155; GO:0008201; GO:0005578 calcium ion binding; cell adhesion; heparin binding; proteinaceous extracellular matrix IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR000436; Fibulin-7 (FIBL-7) (Protein TM14) Fbln7 Tm14 Mus musculus (Mouse) TR25323_c0_g2_i1 Q4LDE5 SVEP1_HUMAN 2.00E-07 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) TR25325_c0_g1_i1 Q5PXE9 IPPK_RAT 7.00E-56 GO:0005524; GO:0005737; GO:0035299; GO:0052746; GO:0005634 ATP binding; cytoplasm; inositol pentakisphosphate 2-kinase activity; inositol phosphorylation; nucleus IPR009286; "Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase) (rIPK1)" Ippk Rattus norvegicus (Rat) TR25325_c0_g1_i3 Q5PXE9 IPPK_RAT 1.00E-25 GO:0005524; GO:0005737; GO:0035299; GO:0052746; GO:0005634 ATP binding; cytoplasm; inositol pentakisphosphate 2-kinase activity; inositol phosphorylation; nucleus IPR009286; "Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase) (rIPK1)" Ippk Rattus norvegicus (Rat) TR25326_c1_g1_i4 Q96RW7 HMCN1_HUMAN 9.00E-06 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR25327_c0_g1_i1 O08863 BIRC3_MOUSE 6.00E-08 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 P39429 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Inhibitor of apoptosis protein 1) (IAP-1) (mIAP-1) (mIAP1) Birc3 Birc2 Iap1 Mus musculus (Mouse) TR25327_c0_g1_i2 Q9S752 LOFG2_ARATH 2.00E-06 GO:0080144; GO:0005886; GO:0004842; GO:0008270 O81775 amino acid homeostasis; plasma membrane; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase LOG2 (EC 6.3.2.-) (Protein LOSS OF GDU2) (RING finger protein 215) LOG2 RF215 RIG2 At3g09770 F11F8.36 F8A24.18 Arabidopsis thaliana (Mouse-ear cress) TR25329_c0_g1_i6 Q92859 NEO1_HUMAN 4.00E-06 GO:0007411; GO:0007155; GO:0005887; GO:0055072; GO:0042692; GO:0007520; GO:0051149; GO:0004872; GO:0006355 "axon guidance; cell adhesion; integral to plasma membrane; iron ion homeostasis; muscle cell differentiation; myoblast fusion; positive regulation of muscle cell differentiation; receptor activity; regulation of transcription, DNA-dependent" IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR010560; Neogenin (Immunoglobulin superfamily DCC subclass member 2) NEO1 IGDCC2 NGN Homo sapiens (Human) TR25332_c0_g1_i1 Q4U0S5 PAF1_DANRE 4.00E-146 GO:0016593; GO:0000993; GO:0007507; GO:0000122; GO:0032968; GO:0045944; GO:0006351 "Cdc73/Paf1 complex; RNA polymerase II core binding; heart development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR007133; RNA polymerase II-associated factor 1 homolog (PD2-like protein) paf1 paf1l Danio rerio (Zebrafish) (Brachydanio rerio) TR25333_c3_g1_i1 P21803 FGFR2_MOUSE 6.00E-46 GO:0005524; GO:0005794; GO:0001525; GO:0006915; GO:0007409; GO:0030282; GO:0060667; GO:0060670; GO:0048755; GO:0060449; GO:0045165; GO:0060365; GO:0016023; GO:0048701; GO:0048557; GO:0009880; GO:0061031; GO:0060664; GO:0060076; GO:0005576; GO:0017134; GO:0035603; GO:0060595; GO:0035602; GO:0035607; GO:0035604; GO:0005007; GO:0031069; GO:0008201; GO:0016021; GO:0032808; GO:0060601; GO:0070307; GO:0060174; GO:0048286; GO:0060463; GO:0060484; GO:0060615; GO:0003149; GO:0060915; GO:0060916; GO:0030901; GO:0035264; GO:0008285; GO:0045839; GO:0000122; GO:0007528; GO:0005634; GO:0042476; GO:0035265; GO:0030916; GO:0003148; GO:0018108; GO:0005886; GO:0070374; GO:0090263; GO:0060045; GO:0045787; GO:0051781; GO:0060501; GO:0002053; GO:0045944; GO:0009791; GO:0060527; GO:0060523; GO:0021860; GO:0060687; GO:0010453; GO:0040036; GO:0040014; GO:0051150; GO:0008589; GO:0060529; GO:0048489; GO:0001657; GO:0060979; GO:0055010; GO:0021847 ATP binding; Golgi apparatus; angiogenesis; apoptotic process; axonogenesis; bone mineralization; branch elongation involved in salivary gland morphogenesis; branching involved in labyrinthine layer morphogenesis; branching morphogenesis of a nerve; bud elongation involved in lung branching; cell fate commitment; coronal suture morphogenesis; cytoplasmic membrane-bounded vesicle; embryonic cranial skeleton morphogenesis; embryonic digestive tract morphogenesis; embryonic pattern specification; endodermal digestive tract morphogenesis; epithelial cell proliferation involved in salivary gland morphogenesis; excitatory synapse; extracellular region; fibroblast growth factor binding; fibroblast growth factor receptor signaling pathway involved in hemopoiesis; fibroblast growth factor receptor signaling pathway involved in mammary gland specification; fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow; fibroblast growth factor-activated receptor activity; hair follicle morphogenesis; heparin binding; integral to membrane; lacrimal gland development; lateral sprouting from an epithelium; lens fiber cell development; limb bud formation; lung alveolus development; lung lobe morphogenesis; lung-associated mesenchyme development; mammary gland bud formation; membranous septum morphogenesis; mesenchymal cell differentiation involved in lung development; mesenchymal cell proliferation involved in lung development; midbrain development; multicellular organism growth; negative regulation of cell proliferation; negative regulation of mitosis; negative regulation of transcription from RNA polymerase II promoter; neuromuscular junction development; nucleus; odontogenesis; organ growth; otic vesicle formation; outflow tract septum morphogenesis; peptidyl-tyrosine phosphorylation; plasma membrane; positive regulation of ERK1 and ERK2 cascade; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle; positive regulation of cell division; positive regulation of epithelial cell proliferation involved in lung morphogenesis; positive regulation of mesenchymal cell proliferation; positive regulation of transcription from RNA polymerase II promoter; post-embryonic development; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; prostate epithelial cord elongation; pyramidal neuron development; regulation of branching involved in prostate gland morphogenesis; regulation of cell fate commitment; regulation of fibroblast growth factor receptor signaling pathway; regulation of multicellular organism growth; regulation of smooth muscle cell differentiation; regulation of smoothened signaling pathway; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; synaptic vesicle transport; ureteric bud development; vasculogenesis involved in coronary vascular morphogenesis; ventricular cardiac muscle tissue morphogenesis; ventricular zone neuroblast division IPR028175; IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (Keratinocyte growth factor receptor) (KGFR) (CD antigen CD332) Fgfr2 Bek Ect1 Mus musculus (Mouse) TR25333_c3_g2_i1 P55245 EGFR_MACMU 2.00E-14 GO:0005524; GO:0000139; GO:0016323; GO:0000902; GO:0008283; GO:0016337; GO:0071392; GO:0021795; GO:0003682; GO:0048546; GO:0001892; GO:0030139; GO:0005789; GO:0005768; GO:0010008; GO:0005006; GO:0001942; GO:0045121; GO:0060571; GO:0043066; GO:0042177; GO:0030235; GO:0031965; GO:0005634; GO:0048471; GO:0045739; GO:0045740; GO:0070374; GO:0043406; GO:0035413; GO:0030335; GO:0031659; GO:0050679; GO:0048146; GO:0045429; GO:0051897; GO:0001934; GO:0045944; GO:0046777; GO:0004713; GO:0050999; GO:0050730; GO:0070141; GO:0007435 ATP binding; Golgi membrane; basolateral plasma membrane; cell morphogenesis; cell proliferation; cell-cell adhesion; cellular response to estradiol stimulus; cerebral cortex cell migration; chromatin binding; digestive tract morphogenesis; embryonic placenta development; endocytic vesicle; endoplasmic reticulum membrane; endosome; endosome membrane; epidermal growth factor-activated receptor activity; hair follicle development; membrane raft; morphogenesis of an epithelial fold; negative regulation of apoptotic process; negative regulation of protein catabolic process; nitric-oxide synthase regulator activity; nuclear membrane; nucleus; perinuclear region of cytoplasm; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAP kinase activity; positive regulation of catenin import into nucleus; positive regulation of cell migration; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of nitric oxide biosynthetic process; positive regulation of protein kinase B signaling cascade; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein autophosphorylation; protein tyrosine kinase activity; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; response to UV-A; salivary gland morphogenesis IPR011009; IPR000719; IPR001245; Epidermal growth factor receptor (EC 2.7.10.1) (Fragment) EGFR Macaca mulatta (Rhesus macaque) TR25333_c3_g3_i2 Q9SYS3 CRK40_ARATH 1.00E-09 GO:0005524; GO:0016021; GO:0004674 ATP binding; integral to membrane; protein serine/threonine kinase activity IPR013320; IPR002902; IPR011009; IPR000719; IPR017441; IPR008271; Cysteine-rich receptor-like protein kinase 40 (Cysteine-rich RLK40) (EC 2.7.11.-) CRK40 At4g04570 F4H6.9 Arabidopsis thaliana (Mouse-ear cress) TR25335_c0_g1_i1 Q32PJ6 CIAO1_BOVIN 4.00E-09 GO:0097361; GO:0071817; GO:0007059; GO:0016226 CIA complex; MMXD complex; chromosome segregation; iron-sulfur cluster assembly IPR015943; IPR001680; IPR019775; IPR017986; Probable cytosolic iron-sulfur protein assembly protein CIAO1 (WD repeat-containing protein 39) CIAO1 WDR39 Bos taurus (Bovine) TR25335_c0_g1_i2 Q6ZMY6 WDR88_HUMAN 2.00E-84 IPR020472; IPR018391; IPR002372; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 88 (PQQ repeat and WD repeat-containing protein) WDR88 PQWD Homo sapiens (Human) TR25339_c1_g1_i1 Q8NEA9 GMCLL_HUMAN 8.00E-57 GO:0030154; GO:0007275; GO:0016363; GO:0016567; GO:0007283 Q9UEU5 cell differentiation; multicellular organismal development; nuclear matrix; protein ubiquitination; spermatogenesis IPR000210; IPR011333; IPR013069; Protein modification; protein ubiquitination. Putative germ cell-less protein-like 1-like GMCL1P1 GCL GMCL1L Homo sapiens (Human) TR25341_c0_g1_i1 P27615 SCRB2_RAT 7.00E-37 GO:0007155; GO:0016021; GO:0043202; GO:0005765; GO:0006622; GO:0004872 cell adhesion; integral to membrane; lysosomal lumen; lysosomal membrane; protein targeting to lysosome; receptor activity IPR002159; IPR005429; Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36) Scarb2 Cd36l2 Limpii Rattus norvegicus (Rat) TR25345_c1_g1_i1 Q95R48 OCTL_DROME 1.00E-34 GO:0007390; GO:0016021; GO:0015101; GO:0030307; GO:0040018 germ-band shortening; integral to membrane; organic cation transmembrane transporter activity; positive regulation of cell growth; positive regulation of multicellular organism growth IPR020846; IPR016196; IPR005828; Organic cation transporter-like protein Orct2 CG13610 Drosophila melanogaster (Fruit fly) TR25345_c1_g1_i2 Q8N4F4 S22AO_HUMAN 1.00E-13 GO:0016021; GO:0006811; GO:0055085 integral to membrane; ion transport; transmembrane transport IPR011701; IPR020846; IPR016196; Solute carrier family 22 member 24 SLC22A24 Homo sapiens (Human) TR25346_c2_g1_i1 Q8BX22 SALL4_MOUSE 2.00E-14 GO:0003677; GO:0005737; GO:0030326; GO:0000792; GO:0001833; GO:0046872; GO:0000122; GO:0001843; GO:0005634; GO:0045944; GO:0019827; GO:0005667; GO:0006351; GO:0003281 Q9R190; Q7TSZ8; Q9UHY1; O70230 "DNA binding; cytoplasm; embryonic limb morphogenesis; heterochromatin; inner cell mass cell proliferation; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; neural tube closure; nucleus; positive regulation of transcription from RNA polymerase II promoter; stem cell maintenance; transcription factor complex; transcription, DNA-dependent; ventricular septum development" IPR007087; IPR015880; IPR013087; Sal-like protein 4 (Zinc finger protein SALL4) Sall4 Mus musculus (Mouse) TR25346_c3_g1_i1 Q4R6C2 ZN383_MACFA 1.00E-49 GO:0003677; GO:0005737; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cytoplasm; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 383 ZNF383 QtsA-18358 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR25347_c0_g1_i1 Q502G2 T41AA_DANRE 3.00E-83 GO:0016021 integral to membrane IPR015414; Transmembrane protein 41A-A tmem41aa tmem41a si:dkeyp-30d5.3 zgc:112259 Danio rerio (Zebrafish) (Brachydanio rerio) TR25348_c1_g1_i1 P14084 SRC_AVISS 3.00E-07 GO:0005524; GO:0004715; GO:0018108 ATP binding; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) (p60-Src) (v-Src) V-SRC Avian sarcoma virus (strain S1) TR25351_c0_g1_i1 Q9Y7Z2 ARF6_SCHPO 1.00E-16 GO:0006888; GO:0005525; GO:0003924; GO:0000139; GO:0051519; GO:0000935; GO:0051285; GO:0006886; GO:0005886; GO:0007264 ER to Golgi vesicle-mediated transport; GTP binding; GTPase activity; Golgi membrane; activation of bipolar cell growth; barrier septum; cell cortex of cell tip; intracellular protein transport; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor 6 arf6 SPBC1539.08 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR25351_c0_g1_i2 Q8N8L6 ARL10_HUMAN 4.00E-16 GO:0005525; GO:0005622; GO:0007264 GTP binding; intracellular; small GTPase mediated signal transduction IPR027417; IPR024156; IPR006689; ADP-ribosylation factor-like protein 10 ARL10 ARL10A Homo sapiens (Human) TR25354_c1_g1_i1 Q8CDY7 TC1D4_MOUSE 4.00E-19 IPR005334; Tctex1 domain-containing protein 4 Tctex1d4 Mus musculus (Mouse) TR25355_c2_g1_i1 Q6ZWR6 SYNE1_MOUSE 3.00E-16 GO:0005856; GO:0040023; GO:0016021; GO:0005635; GO:0005640; GO:0042803; GO:0030017 cytoskeleton; establishment of nucleus localization; integral to membrane; nuclear envelope; nuclear outer membrane; protein homodimerization activity; sarcomere IPR001589; IPR001715; IPR012315; IPR018159; IPR002017; Nesprin-1 (Enaptin) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) Syne1 Mus musculus (Mouse) TR25359_c0_g3_i1 Q15256 PTPRR_HUMAN 5.00E-113 GO:0009986; GO:0005737; GO:0001701; GO:0016021; GO:0005634; GO:0048471; GO:0005886; GO:0019901; GO:0005001 Q16539 cell surface; cytoplasm; in utero embryonic development; integral to membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; protein kinase binding; transmembrane receptor protein tyrosine phosphatase activity IPR000387; IPR016130; IPR008356; IPR000242; IPR016334; Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1) PTPRR ECPTP PTPRQ Homo sapiens (Human) TR25361_c0_g1_i1 Q5R231 ACTP1_ACTVL 2.00E-06 GO:0006812; GO:0015267; GO:0019835; GO:0052331; GO:0042151; GO:0044218; GO:0046930; GO:0046931 cation transport; channel activity; cytolysis; hemolysis in other organism involved in symbiotic interaction; nematocyst; other organism cell membrane; pore complex; pore complex assembly IPR009104; IPR015926; Hemolytic toxin Avt-1 (Avt-I) Actineria villosa (Okinawan sea anemone) TR25366_c0_g1_i2 Q9NXL2 ARH38_HUMAN 4.00E-13 GO:0005089; GO:0035023 Rho guanyl-nucleotide exchange factor activity; regulation of Rho protein signal transduction IPR000219; Rho guanine nucleotide exchange factor 38 ARHGEF38 Homo sapiens (Human) TR25368_c3_g1_i1 O15013 ARHGA_HUMAN 7.00E-42 GO:0005089; GO:0005813; GO:0051298; GO:0005829; GO:0022011; GO:0033126; GO:0051496; GO:0035023; GO:0090307 O15066 Rho guanyl-nucleotide exchange factor activity; centrosome; centrosome duplication; cytosol; myelination in peripheral nervous system; positive regulation of GTP catabolic process; positive regulation of stress fiber assembly; regulation of Rho protein signal transduction; spindle assembly involved in mitosis IPR000219; IPR015943; IPR017986; Rho guanine nucleotide exchange factor 10 ARHGEF10 KIAA0294 Homo sapiens (Human) TR25368_c4_g1_i1 Q9H8V3 ECT2_HUMAN 1.00E-05 GO:0005096; GO:0005089; GO:0032863; GO:0032147; GO:0097190; GO:0000902; GO:0071277; GO:0070301; GO:0071479; GO:0097149; GO:0032154; GO:0000910; GO:0005829; GO:0030496; GO:0048011; GO:0005634; GO:0005543; GO:0043089; GO:0043123; GO:0043065; GO:0032467; GO:0045666; GO:0042307; GO:0042803; GO:0051260; GO:0015031; GO:0051988; GO:0004871; GO:0007264; GO:0005923; GO:0070830 P16333 GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; activation of Rac GTPase activity; activation of protein kinase activity; apoptotic signaling pathway; cell morphogenesis; cellular response to calcium ion; cellular response to hydrogen peroxide; cellular response to ionizing radiation; centralspindlin complex; cleavage furrow; cytokinesis; cytosol; midbody; neurotrophin TRK receptor signaling pathway; nucleus; phospholipid binding; positive regulation of Cdc42 GTPase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptotic process; positive regulation of cytokinesis; positive regulation of neuron differentiation; positive regulation of protein import into nucleus; protein homodimerization activity; protein homooligomerization; protein transport; regulation of attachment of spindle microtubules to kinetochore; signal transducer activity; small GTPase mediated signal transduction; tight junction; tight junction assembly IPR001357; IPR000219; IPR026817; IPR001331; IPR011993; IPR001849; Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) ECT2 Homo sapiens (Human) TR25372_c1_g1_i1 Q869Z0 Y5025_DICDI 7.00E-19 GO:0045454; GO:0005788; GO:0006662; GO:0003756; GO:0015035; GO:0006457 cell redox homeostasis; endoplasmic reticulum lumen; glycerol ether metabolic process; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; protein folding IPR005788; IPR005746; IPR012336; IPR017937; IPR013766; Putative protein disulfide-isomerase DDB_G0275025 (EC 5.3.4.1) DDB_G0275025 Dictyostelium discoideum (Slime mold) TR25372_c2_g1_i1 Q498R3 DJC10_RAT 2.00E-19 GO:0001671; GO:0030433; GO:0045454; GO:0034663; GO:0005788; GO:0070059; GO:0001933; GO:0016671; GO:0015035; GO:0034975 "ATPase activator activity; ER-associated protein catabolic process; cell redox homeostasis; endoplasmic reticulum chaperone complex; endoplasmic reticulum lumen; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; negative regulation of protein phosphorylation; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; protein disulfide oxidoreductase activity; protein folding in endoplasmic reticulum" IPR001623; IPR021170; IPR012336; IPR017937; IPR013766; DnaJ homolog subfamily C member 10 (EC 1.8.4.-) Dnajc10 Rattus norvegicus (Rat) TR25373_c0_g1_i1 B0VXE8 CDK14_CALJA 3.00E-63 GO:0005524; GO:0000086; GO:0016055; GO:0051301; GO:0004693; GO:0000308; GO:0005634; GO:0005886; GO:0060828 ATP binding; G2/M transition of mitotic cell cycle; Wnt receptor signaling pathway; cell division; cyclin-dependent protein serine/threonine kinase activity; cytoplasmic cyclin-dependent protein kinase holoenzyme complex; nucleus; plasma membrane; regulation of canonical Wnt receptor signaling pathway IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) CDK14 PFTK1 Callithrix jacchus (White-tufted-ear marmoset) TR25373_c0_g2_i1 B0VXE8 CDK14_CALJA 3.00E-63 GO:0005524; GO:0000086; GO:0016055; GO:0051301; GO:0004693; GO:0000308; GO:0005634; GO:0005886; GO:0060828 ATP binding; G2/M transition of mitotic cell cycle; Wnt receptor signaling pathway; cell division; cyclin-dependent protein serine/threonine kinase activity; cytoplasmic cyclin-dependent protein kinase holoenzyme complex; nucleus; plasma membrane; regulation of canonical Wnt receptor signaling pathway IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) CDK14 PFTK1 Callithrix jacchus (White-tufted-ear marmoset) TR25373_c1_g1_i1 Q96Q40 CDK15_HUMAN 3.00E-55 GO:0005524; GO:0004693; GO:0046872 P08238 ATP binding; cyclin-dependent protein serine/threonine kinase activity; metal ion binding IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 15 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) (Cell division protein kinase 15) (Serine/threonine-protein kinase ALS2CR7) (Serine/threonine-protein kinase PFTAIRE-2) CDK15 ALS2CR7 PFTK2 Homo sapiens (Human) TR25374_c0_g1_i1 Q9VTJ8 TIM14_DROME 2.00E-44 GO:0001671; GO:0016021; GO:0022008; GO:0001405; GO:0030150 ATPase activator activity; integral to membrane; neurogenesis; presequence translocase-associated import motor; protein import into mitochondrial matrix IPR001623; Mitochondrial import inner membrane translocase subunit TIM14 Tim14 CG7394 Drosophila melanogaster (Fruit fly) TR25376_c2_g1_i1 Q8IYR2 SMYD4_HUMAN 2.00E-51 GO:0046872; GO:0008168 metal ion binding; methyltransferase activity IPR001214; IPR011990; IPR002893; SET and MYND domain-containing protein 4 (EC 2.1.1.-) SMYD4 KIAA1936 Homo sapiens (Human) TR25376_c3_g1_i1 Q9D4H7 LONF3_MOUSE 3.00E-06 GO:0004176; GO:0006508; GO:0008270 ATP-dependent peptidase activity; proteolysis; zinc ion binding IPR003111; IPR015947; IPR013026; IPR011990; IPR013105; IPR019734; IPR001841; IPR013083; IPR017907; LON peptidase N-terminal domain and RING finger protein 3 (RING finger protein 127) Lonrf3 Rnf127 Mus musculus (Mouse) TR25377_c1_g1_i1 Q400C8 AMZ2_MOUSE 5.00E-33 GO:0008237; GO:0006508; GO:0008270 metallopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR012962; Archaemetzincin-2 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 2) Amz2 Mus musculus (Mouse) TR25379_c0_g1_i1 Q5BIM8 ERCC8_BOVIN 7.00E-138 GO:0031464; GO:0016363; GO:0000109; GO:0045739; GO:0043161; GO:0051865; GO:0043234; GO:0032403; GO:0000209; GO:0009411; GO:0006979; GO:0006283; GO:0004842 Cul4A-RING ubiquitin ligase complex; nuclear matrix; nucleotide-excision repair complex; positive regulation of DNA repair; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein complex; protein complex binding; protein polyubiquitination; response to UV; response to oxidative stress; transcription-coupled nucleotide-excision repair; ubiquitin-protein ligase activity IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. DNA excision repair protein ERCC-8 ERCC8 Bos taurus (Bovine) TR25383_c0_g2_i2 E9PUL5 PRRT2_MOUSE 9.00E-06 GO:0030054; GO:0016021; GO:0005886; GO:0009607; GO:0045202 cell junction; integral to membrane; plasma membrane; response to biotic stimulus; synapse IPR007593; Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3) Prrt2 Mus musculus (Mouse) TR25385_c0_g1_i1 Q5MYT9 OASL2_RAT 4.00E-24 GO:0001730; GO:0005524; GO:0051607; GO:0003725; GO:0045087; GO:0046872; GO:0006164; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; defense response to virus; double-stranded RNA binding; innate immune response; metal ion binding; purine nucleotide biosynthetic process; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR022617; IPR000626; 2'-5'-oligoadenylate synthase-like protein 2 (EC 2.7.7.84) Oasl2 Rattus norvegicus (Rat) TR25391_c2_g1_i1 P21369 PNCA_ECOLI 9.00E-25 GO:0008936; GO:0019363 nicotinamidase activity; pyridine nucleotide biosynthetic process IPR000868; Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1. Pyrazinamidase/nicotinamidase (PZAase) (EC 3.5.1.-) (EC 3.5.1.19) (Nicotine deamidase) (NAMase) pncA nam ydjB b1768 JW1757 Escherichia coli (strain K12) TR25394_c0_g1_i3 P57788 MOT4_CHICK 8.00E-22 GO:0015629; GO:0016021; GO:0031965; GO:0005886; GO:0015355; GO:0015293 actin cytoskeleton; integral to membrane; nuclear membrane; plasma membrane; secondary active monocarboxylate transmembrane transporter activity; symporter activity IPR011701; IPR020846; IPR016196; IPR004743; Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3) SLC16A3 MCT4 Gallus gallus (Chicken) TR25398_c0_g2_i2 Q9H9L3 I20L2_HUMAN 4.00E-33 GO:0004527; GO:0003676; GO:0090305; GO:0005730; GO:0005634; GO:0042254 O00423; P16333 exonuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis; nucleolus; nucleus; ribosome biogenesis IPR006055; IPR013520; IPR012337; Interferon-stimulated 20 kDa exonuclease-like 2 (EC 3.1.-.-) ISG20L2 HSD-38 HSD38 Homo sapiens (Human) TR25398_c0_g2_i3 Q5REE2 AEN_PONAB 1.00E-34 GO:0004527; GO:0042771; GO:0003676; GO:0005730; GO:0005654; GO:0010212 exonuclease activity; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; nucleic acid binding; nucleolus; nucleoplasm; response to ionizing radiation IPR006055; IPR013520; IPR012337; Apoptosis-enhancing nuclease (EC 3.1.-.-) (Interferon-stimulated 20 kDa exonuclease-like 1) AEN ISG20L1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR25401_c3_g2_i1 Q875S9 AKR1_LACK1 5.00E-06 GO:0000139; GO:0031901; GO:0016021; GO:0016746; GO:0008270 "Golgi membrane; early endosome membrane; integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR002110; IPR020683; IPR001594; Palmitoyltransferase AKR1 (EC 2.3.1.225) (Ankyrin repeat-containing protein AKR1) AKR1 Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / CCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651) (Yeast) (Saccharomyces kluyveri) TR25401_c5_g1_i1 Q5ZIJ9 MIB2_CHICK 2.00E-46 GO:0007219; GO:0005737; GO:0004842; GO:0008270 Notch signaling pathway; cytoplasm; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) TR25403_c1_g1_i1 P10417 BCL2_MOUSE 9.00E-22 GO:0001782; GO:0002326; GO:0042100; GO:0050853; GO:0043375; GO:0033077; GO:0043029; GO:0007015; GO:0031103; GO:0007409; GO:0001662; GO:0001658; GO:0007569; GO:0016049; GO:0016337; GO:0042149; GO:0071456; GO:0071310; GO:0015267; GO:0016248; GO:0021747; GO:0005829; GO:0051607; GO:0048589; GO:0048546; GO:0043583; GO:0032469; GO:0005789; GO:0097192; GO:0008625; GO:0048041; GO:0022612; GO:0032835; GO:0031069; GO:0048873; GO:0070059; GO:0008631; GO:0002320; GO:0008584; GO:0006582; GO:0030318; GO:0014031; GO:0001656; GO:0031966; GO:0005741; GO:0043209; GO:2000134; GO:2000811; GO:2001234; GO:0010523; GO:0030308; GO:0030336; GO:0032848; GO:2001243; GO:0045930; GO:0033033; GO:0043524; GO:0030279; GO:0033689; GO:0046671; GO:0051402; GO:0031965; GO:0048599; GO:0035265; GO:0001503; GO:0001541; GO:0018105; GO:0018107; GO:0048753; GO:0046930; GO:0030890; GO:0043085; GO:0030307; GO:0008284; GO:0045636; GO:0040018; GO:0014042; GO:0033138; GO:0048743; GO:0014911; GO:0009791; GO:0006470; GO:0051721; GO:0000209; GO:0072593; GO:0001952; GO:0010559; GO:0046902; GO:0051881; GO:0006808; GO:0043497; GO:0043496; GO:0032880; GO:0031647; GO:0022898; GO:0045069; GO:0001836; GO:0003014; GO:0006974; GO:0010224; GO:0001101; GO:0034097; GO:0042493; GO:0010332; GO:0051384; GO:0042542; GO:0010039; GO:0002931; GO:0035094; GO:0009636; GO:0043565; GO:0048536; GO:0048538 Q07813; O54918-1 "B cell homeostasis; B cell lineage commitment; B cell proliferation; B cell receptor signaling pathway; CD8-positive, alpha-beta T cell lineage commitment; T cell differentiation in thymus; T cell homeostasis; actin filament organization; axon regeneration; axonogenesis; behavioral fear response; branching involved in ureteric bud morphogenesis; cell aging; cell growth; cell-cell adhesion; cellular response to glucose starvation; cellular response to hypoxia; cellular response to organic substance; channel activity; channel inhibitor activity; cochlear nucleus development; cytosol; defense response to virus; developmental growth; digestive tract morphogenesis; ear development; endoplasmic reticulum calcium ion homeostasis; endoplasmic reticulum membrane; extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; focal adhesion assembly; gland morphogenesis; glomerulus development; hair follicle morphogenesis; homeostasis of number of cells within a tissue; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to oxidative stress; lymphoid progenitor cell differentiation; male gonad development; melanin metabolic process; melanocyte differentiation; mesenchymal cell development; metanephros development; mitochondrial membrane; mitochondrial outer membrane; myelin sheath; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of anoikis; negative regulation of apoptotic signaling pathway; negative regulation of calcium ion transport into cytosol; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cellular pH reduction; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of mitotic cell cycle; negative regulation of myeloid cell apoptotic process; negative regulation of neuron apoptotic process; negative regulation of ossification; negative regulation of osteoblast proliferation; negative regulation of retinal cell programmed cell death; neuron apoptotic process; nuclear membrane; oocyte development; organ growth; ossification; ovarian follicle development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pigment granule organization; pore complex; positive regulation of B cell proliferation; positive regulation of catalytic activity; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of melanocyte differentiation; positive regulation of multicellular organism growth; positive regulation of neuron maturation; positive regulation of peptidyl-serine phosphorylation; positive regulation of skeletal muscle fiber development; positive regulation of smooth muscle cell migration; post-embryonic development; protein dephosphorylation; protein phosphatase 2A binding; protein polyubiquitination; reactive oxygen species metabolic process; regulation of cell-matrix adhesion; regulation of glycoprotein biosynthetic process; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; regulation of nitrogen utilization; regulation of protein heterodimerization activity; regulation of protein homodimerization activity; regulation of protein localization; regulation of protein stability; regulation of transmembrane transporter activity; regulation of viral genome replication; release of cytochrome c from mitochondria; renal system process; response to DNA damage stimulus; response to UV-B; response to acid; response to cytokine stimulus; response to drug; response to gamma radiation; response to glucocorticoid stimulus; response to hydrogen peroxide; response to iron ion; response to ischemia; response to nicotine; response to toxic substance; sequence-specific DNA binding; spleen development; thymus development" IPR013278; IPR002475; IPR004725; IPR020717; IPR020726; IPR020728; IPR003093; IPR020731; IPR026298; Apoptosis regulator Bcl-2 Bcl2 Bcl-2 Mus musculus (Mouse) TR25405_c0_g1_i1 P90921 ATPL1_CAEEL 2.00E-09 GO:0015986; GO:0015078; GO:0000276 "ATP synthesis coupled proton transport; hydrogen ion transmembrane transporter activity; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)" IPR016702; IPR006808; "Probable ATP synthase subunit g 1, mitochondrial (ATPase subunit g 1)" asg-1 K07A12.3 Caenorhabditis elegans TR25405_c0_g1_i2 Q6PDU7 ATP5L_RAT 2.00E-21 GO:0046034; GO:0015986; GO:0015078; GO:0000276 "ATP metabolic process; ATP synthesis coupled proton transport; hydrogen ion transmembrane transporter activity; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)" IPR016702; IPR006808; "ATP synthase subunit g, mitochondrial (ATPase subunit g)" Atp5l Rattus norvegicus (Rat) TR25407_c0_g1_i1 Q8IYB7 DI3L2_HUMAN 1.00E-50 GO:0000175; GO:0003723; GO:0051301; GO:0000932; GO:0010587; GO:0051306; GO:0008285; GO:0000291; GO:0005844; GO:1990074; GO:0019827 "3'-5'-exoribonuclease activity; RNA binding; cell division; cytoplasmic mRNA processing body; miRNA catabolic process; mitotic sister chromatid separation; negative regulation of cell proliferation; nuclear-transcribed mRNA catabolic process, exonucleolytic; polysome; polyuridylation-dependent mRNA catabolic process; stem cell maintenance" IPR012340; IPR022966; DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-) DIS3L2 FAM6A Homo sapiens (Human) TR25410_c1_g1_i1 P50226 ST1A2_HUMAN 3.00E-35 GO:0050427; GO:0009309; GO:0004062; GO:0006584; GO:0005829; GO:0047894; GO:0018958; GO:0008202; GO:0051923; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; amine biosynthetic process; aryl sulfotransferase activity; catecholamine metabolic process; cytosol; flavonol 3-sulfotransferase activity; phenol-containing compound metabolic process; steroid metabolic process; sulfation; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase 1A2 (ST1A2) (EC 2.8.2.1) (Aryl sulfotransferase 2) (Phenol sulfotransferase 2) (Phenol-sulfating phenol sulfotransferase 2) (P-PST 2) SULT1A2 STP2 Homo sapiens (Human) TR25414_c0_g1_i1 Q6EMK4 VASN_HUMAN 7.00E-17 GO:0071456; GO:0071461; GO:0005576; GO:0016021; GO:0005765; GO:0005739; GO:0005886 cellular response to hypoxia; cellular response to redox state; extracellular region; integral to membrane; lysosomal membrane; mitochondrion; plasma membrane IPR000483; IPR000742; IPR013032; IPR003961; IPR013783; IPR001611; IPR003591; IPR000372; Vasorin (Protein slit-like 2) VASN SLITL2 UNQ314/PRO357/PRO1282 Homo sapiens (Human) TR25414_c0_g1_i2 Q9WVB4 SLIT3_MOUSE 7.00E-14 GO:0035385; GO:0061364; GO:0048846; GO:0007411; GO:0005509; GO:0032870; GO:0005615; GO:0050919; GO:0030308; GO:0008285; GO:0070100; GO:0010629; GO:0009887; GO:0005102; GO:0051414 Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; axon guidance; calcium ion binding; cellular response to hormone stimulus; extracellular space; negative chemotaxis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of chemokine-mediated signaling pathway; negative regulation of gene expression; organ morphogenesis; receptor binding; response to cortisol stimulus IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 3 protein (Slit-3) (Slit3) Slit3 Mus musculus (Mouse) TR25417_c0_g1_i1 P83425 HIP_MYTED 3.00E-124 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR25417_c0_g1_i2 Q4ZJM9 C1QL4_MOUSE 9.00E-07 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) TR25419_c1_g1_i1 Q5RC65 NHP2_PONAB 4.00E-55 GO:0015030; GO:0005730; GO:0031118; GO:0005732; GO:0030515 Cajal body; nucleolus; rRNA pseudouridine synthesis; small nucleolar ribonucleoprotein complex; snoRNA binding IPR002415; IPR004038; IPR018492; H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2) NHP2 NOLA2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR25432_c2_g1_i1 Q59WJ4 PFS2_CANAL 5.00E-08 GO:0051301; GO:0000753; GO:0007059; GO:0044182; GO:0006397; GO:0007067; GO:1900429; GO:0005634; GO:0000750 cell division; cell morphogenesis involved in conjugation with cellular fusion; chromosome segregation; filamentous growth of a population of unicellular organisms; mRNA processing; mitosis; negative regulation of filamentous growth of a population of unicellular organisms; nucleus; pheromone-dependent signal transduction involved in conjugation with cellular fusion IPR015943; IPR001680; IPR017986; Polyadenylation factor subunit 2 PFS2 CaO19.2307 CaO19.9843 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) TR25435_c0_g2_i1 Q7Z6K3 PTAR1_HUMAN 2.00E-26 GO:0018342; GO:0008318 protein prenylation; protein prenyltransferase activity IPR002088; Protein prenyltransferase alpha subunit repeat-containing protein 1 PTAR1 Homo sapiens (Human) TR25437_c0_g1_i1 Q9ESN4 C1QL3_MOUSE 2.00E-07 GO:0005581; GO:0005576; GO:0050807 collagen; extracellular region; regulation of synapse organization IPR001073; IPR008160; IPR008983; Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13) (CTRP13) (Gliacolin) C1ql3 C1ql Ctrp13 Mus musculus (Mouse) TR25443_c2_g1_i1 Q9CZJ2 HS12B_MOUSE 1.00E-25 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR25449_c0_g1_i1 P08419 CEL2A_PIG 9.00E-21 GO:0005576; GO:0006508; GO:0004252 extracellular region; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Chymotrypsin-like elastase family member 2A (EC 3.4.21.71) (Elastase-2) (Elastase-2A) CELA2A ELA2 ELA2A Sus scrofa (Pig) TR25453_c1_g1_i1 Q9WVB4 SLIT3_MOUSE 4.00E-13 GO:0035385; GO:0061364; GO:0048846; GO:0007411; GO:0005509; GO:0032870; GO:0005615; GO:0050919; GO:0030308; GO:0008285; GO:0070100; GO:0010629; GO:0009887; GO:0005102; GO:0051414 Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; axon guidance; calcium ion binding; cellular response to hormone stimulus; extracellular space; negative chemotaxis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of chemokine-mediated signaling pathway; negative regulation of gene expression; organ morphogenesis; receptor binding; response to cortisol stimulus IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 3 protein (Slit-3) (Slit3) Slit3 Mus musculus (Mouse) TR25455_c0_g2_i1 Q5QJC4 DCR1A_CHICK 7.00E-45 GO:0016787; GO:0005654; GO:0000715 "hydrolase activity; nucleoplasm; nucleotide-excision repair, DNA damage recognition" IPR001279; IPR011084; DNA cross-link repair 1A protein (SNM1 homolog A) (chSNM1A) DCLRE1A SNM1A Gallus gallus (Chicken) TR25457_c1_g1_i1 P15129 CP4B1_RAT 8.00E-43 GO:0070330; GO:0018879; GO:0008144; GO:0005789; GO:0042738; GO:0018917; GO:0018585; GO:0020037; GO:0043231; GO:0005506; GO:0004497 aromatase activity; biphenyl metabolic process; drug binding; endoplasmic reticulum membrane; exogenous drug catabolic process; fluorene metabolic process; fluorene oxygenase activity; heme binding; intracellular membrane-bounded organelle; iron ion binding; monooxygenase activity IPR001128; IPR017972; IPR002401; Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (Cytochrome P450 L-2) (Cytochrome P450 isozyme 5) Cyp4b1 Cyp4b-1 Rattus norvegicus (Rat) TR25457_c1_g1_i2 Q8N1L4 CP4Z2_HUMAN 1.00E-09 GO:0020037; GO:0016021; GO:0005506; GO:0016705 "heme binding; integral to membrane; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; Putative inactive cytochrome P450 family member 4Z2 CYP4Z2P Homo sapiens (Human) TR25457_c1_g1_i4 P15129 CP4B1_RAT 7.00E-16 GO:0070330; GO:0018879; GO:0008144; GO:0005789; GO:0042738; GO:0018917; GO:0018585; GO:0020037; GO:0043231; GO:0005506; GO:0004497 aromatase activity; biphenyl metabolic process; drug binding; endoplasmic reticulum membrane; exogenous drug catabolic process; fluorene metabolic process; fluorene oxygenase activity; heme binding; intracellular membrane-bounded organelle; iron ion binding; monooxygenase activity IPR001128; IPR017972; IPR002401; Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (Cytochrome P450 L-2) (Cytochrome P450 isozyme 5) Cyp4b1 Cyp4b-1 Rattus norvegicus (Rat) TR25462_c1_g1_i1 P59024 FKB14_MOUSE 5.00E-38 GO:0005528; GO:0005509; GO:0005788; GO:0016020; GO:0003755; GO:0006457 FK506 binding; calcium ion binding; endoplasmic reticulum lumen; membrane; peptidyl-prolyl cis-trans isomerase activity; protein folding IPR011992; IPR018247; IPR002048; IPR023566; IPR001179; Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (FK506-binding protein 14) (FKBP-14) (Rotamase) Fkbp14 Mus musculus (Mouse) TR25463_c1_g1_i1 Q2HJ46 RNF8_BOVIN 1.00E-15 GO:0051301; GO:0003682; GO:0000781; GO:0006303; GO:0070535; GO:0033523; GO:0042393; GO:0043486; GO:0045190; GO:0030496; GO:0007067; GO:0045900; GO:0005634; GO:0045739; GO:0070936; GO:0051865; GO:0042803; GO:0010212; GO:0035861; GO:0007286; GO:0000151; GO:0006511; GO:0004842; GO:0008270 "cell division; chromatin binding; chromosome, telomeric region; double-strand break repair via nonhomologous end joining; histone H2A K63-linked ubiquitination; histone H2B ubiquitination; histone binding; histone exchange; isotype switching; midbody; mitosis; negative regulation of translational elongation; nucleus; positive regulation of DNA repair; protein K48-linked ubiquitination; protein autoubiquitination; protein homodimerization activity; response to ionizing radiation; site of double-strand break; spermatid development; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding" IPR017335; IPR000253; IPR008984; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF8 (EC 6.3.2.-) (RING finger protein 8) RNF8 Bos taurus (Bovine) TR25463_c1_g2_i1 Q5R4I2 RNF8_PONAB 7.00E-15 GO:0051301; GO:0003682; GO:0000781; GO:0006303; GO:0070535; GO:0033523; GO:0042393; GO:0043486; GO:0045190; GO:0030496; GO:0007067; GO:0045900; GO:0005634; GO:0045739; GO:0070936; GO:0042803; GO:0010212; GO:0035861; GO:0007286; GO:0000151; GO:0006511; GO:0004842; GO:0008270 "cell division; chromatin binding; chromosome, telomeric region; double-strand break repair via nonhomologous end joining; histone H2A K63-linked ubiquitination; histone H2B ubiquitination; histone binding; histone exchange; isotype switching; midbody; mitosis; negative regulation of translational elongation; nucleus; positive regulation of DNA repair; protein K48-linked ubiquitination; protein homodimerization activity; response to ionizing radiation; site of double-strand break; spermatid development; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding" IPR017335; IPR000253; IPR008984; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF8 (EC 6.3.2.-) (RING finger protein 8) RNF8 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR25464_c1_g1_i1 Q48436 BUDC_KLEPN 5.00E-15 GO:0045150; GO:0052588 acetoin catabolic process; diacetyl reductase ((S)-acetoin forming) activity IPR014007; IPR002198; IPR002347; IPR016040; IPR020904; "Diacetyl reductase [(S)-acetoin forming] (EC 1.1.1.304) (Acetoin(diacetyl) reductase) (AR) (Meso-2,3-butanediol dehydrogenase)" budC Klebsiella pneumoniae TR25464_c1_g1_i2 Q5M875 DHB13_RAT 3.00E-59 GO:0005576; GO:0016491 extracellular region; oxidoreductase activity IPR002198; IPR002347; IPR016040; 17-beta-hydroxysteroid dehydrogenase 13 (17-beta-HSD 13) (EC 1.1.-.-) (Short-chain dehydrogenase/reductase 9) Hsd17b13 Scdr9 Rattus norvegicus (Rat) TR25464_c1_g1_i3 P46331 YXBG_BACSU 2.00E-06 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Uncharacterized oxidoreductase YxbG (EC 1.-.-.-) yxbG E3BR yxaU BSU39840 Bacillus subtilis (strain 168) TR25464_c1_g1_i4 Q5M875 DHB13_RAT 2.00E-45 GO:0005576; GO:0016491 extracellular region; oxidoreductase activity IPR002198; IPR002347; IPR016040; 17-beta-hydroxysteroid dehydrogenase 13 (17-beta-HSD 13) (EC 1.1.-.-) (Short-chain dehydrogenase/reductase 9) Hsd17b13 Scdr9 Rattus norvegicus (Rat) TR25469_c0_g1_i1 Q8VHC3 SELM_MOUSE 1.00E-08 GO:0005794; GO:0005783; GO:0048471 Golgi apparatus; endoplasmic reticulum; perinuclear region of cytoplasm IPR014912; IPR012336; Selenoprotein M (SelM) Selm Sepm Mus musculus (Mouse) TR25470_c0_g1_i1 Q19673 TYR3_CAEEL 2.00E-06 GO:0046872; GO:0004497 metal ion binding; monooxygenase activity IPR003582; IPR002227; IPR008922; Putative tyrosinase-like protein tyr-3 tyr-3 F21C3.2 Caenorhabditis elegans TR25476_c0_g1_i1 O46419 LIPT_BOVIN 2.00E-12 GO:0005739; GO:0009249; GO:0016746 "mitochondrion; protein lipoylation; transferase activity, transferring acyl groups" IPR004143; IPR004562; Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2. "Lipoyltransferase 1, mitochondrial (EC 2.3.1.-) (Lipoate biosynthesis protein) (Lipoate-protein ligase) (Lipoyl ligase)" LIPT1 Bos taurus (Bovine) TR25480_c0_g1_i1 Q9UIV1 CNOT7_HUMAN 4.00E-147 GO:0030014; GO:0003723; GO:0005975; GO:0000932; GO:0033962; GO:0005829; GO:0000290; GO:0043928; GO:0035195; GO:0046872; GO:0008285; GO:0000289; GO:0005634; GO:0004535; GO:0008284; GO:1900153; GO:0060213; GO:0045944; GO:0006417; GO:0003700; GO:0004871; GO:0006351 Q9UKV8; P62324; P78543; A5YKK6; Q9ULM6; P50616; P22893 "CCR4-NOT complex; RNA binding; carbohydrate metabolic process; cytoplasmic mRNA processing body; cytoplasmic mRNA processing body assembly; cytosol; deadenylation-dependent decapping of nuclear-transcribed mRNA; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; gene silencing by miRNA; metal ion binding; negative regulation of cell proliferation; nuclear-transcribed mRNA poly(A) tail shortening; nucleus; poly(A)-specific ribonuclease activity; positive regulation of cell proliferation; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; positive regulation of transcription from RNA polymerase II promoter; regulation of translation; sequence-specific DNA binding transcription factor activity; signal transducer activity; transcription, DNA-dependent" IPR006941; IPR012337; CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (BTG1-binding factor 1) (CCR4-associated factor 1) (CAF-1) (Caf1a) CNOT7 CAF1 Homo sapiens (Human) TR25481_c0_g1_i1 Q6ZPJ3 UBE2O_MOUSE 4.00E-14 GO:0005524; GO:0004842 ATP binding; ubiquitin-protein ligase activity IPR000608; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 O (EC 6.3.2.19) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) Ube2o Kiaa1734 Mus musculus (Mouse) TR25482_c0_g1_i1 Q8K3J9 GPC5C_MOUSE 4.00E-07 GO:0004930; GO:0016021; GO:0005739; GO:0005886; GO:0007601 G-protein coupled receptor activity; integral to membrane; mitochondrion; plasma membrane; visual perception IPR002956; IPR017978; G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) Gprc5c Raig3 Mus musculus (Mouse) TR25483_c0_g1_i1 A9JRD8 BTB6A_DANRE 2.00E-19 GO:0030154; GO:0000932; GO:0007399 cell differentiation; cytoplasmic mRNA processing body; nervous system development IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6-A btbd6a zgc:172197 Danio rerio (Zebrafish) (Brachydanio rerio) TR25483_c2_g1_i1 Q8C726 BTBD9_MOUSE 2.00E-06 GO:0008344; GO:0007155; GO:0042748; GO:0007616; GO:0060586; GO:1900242; GO:0050951; GO:0042428 "adult locomotory behavior; cell adhesion; circadian sleep/wake cycle, non-REM sleep; long-term memory; multicellular organismal iron ion homeostasis; regulation of synaptic vesicle endocytosis; sensory perception of temperature stimulus; serotonin metabolic process" IPR011705; IPR000210; IPR011333; IPR013069; IPR000421; IPR008979; BTB/POZ domain-containing protein 9 Btbd9 Mus musculus (Mouse) TR25486_c0_g1_i1 B6SFA4 MAA3_ARATH 5.00E-13 GO:0005524; GO:0009553; GO:0004386; GO:0005634; GO:0010183; GO:0009875 ATP binding; embryo sac development; helicase activity; nucleus; pollen tube guidance; pollen-pistil interaction IPR014001; IPR026852; IPR027417; Probable helicase MAGATAMA 3 (EC 3.6.4.-) (SEN1-like protein) MAA3 At4g15570 dl3825w Arabidopsis thaliana (Mouse-ear cress) TR25486_c2_g1_i1 Q92355 SEN1_SCHPO 8.00E-24 GO:0005524; GO:0043141; GO:0032575; GO:0035649; GO:0006397; GO:0005634; GO:0006364; GO:0016180; GO:0043144; GO:0008033; GO:0006369 ATP binding; ATP-dependent 5'-3' DNA helicase activity; ATP-dependent 5'-3' RNA helicase activity; Nrd1 complex; mRNA processing; nucleus; rRNA processing; snRNA processing; snoRNA processing; tRNA processing; termination of RNA polymerase II transcription IPR024714; IPR024481; IPR027417; Helicase sen1 (EC 3.6.4.-) sen1 SPAC6G9.10c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR25490_c2_g2_i1 Q6R7K3 RIR2_OSHVF 1.00E-16 GO:0006260; GO:0009186; GO:0046872; GO:0004748 "DNA replication; deoxyribonucleoside diphosphate metabolic process; metal ion binding; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor" IPR009078; IPR003812; IPR012348; IPR000358; Genetic information processing; DNA replication. Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) ORF20 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) TR25496_c1_g1_i1 Q9BX95 SGPP1_HUMAN 2.00E-24 GO:0006915; GO:0005789; GO:0016021; GO:0044281; GO:0006668; GO:0030148; GO:0006670; GO:0042392 apoptotic process; endoplasmic reticulum membrane; integral to membrane; small molecule metabolic process; sphinganine-1-phosphate metabolic process; sphingolipid biosynthetic process; sphingosine metabolic process; sphingosine-1-phosphate phosphatase activity IPR000326; Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) SGPP1 Homo sapiens (Human) TR25498_c1_g1_i1 Q9EQY0 ERN1_MOUSE 5.00E-10 GO:0005524; GO:0006987; GO:0007050; GO:0005789; GO:0004521; GO:0030176; GO:0070059; GO:0006397; GO:0000287; GO:0005739; GO:0005637; GO:1900103; GO:0046777; GO:0004674; GO:0006355; GO:0006351 P25118 "ATP binding; activation of signaling protein activity involved in unfolded protein response; cell cycle arrest; endoplasmic reticulum membrane; endoribonuclease activity; integral to endoplasmic reticulum membrane; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; mRNA processing; magnesium ion binding; mitochondrion; nuclear inner membrane; positive regulation of endoplasmic reticulum unfolded protein response; protein autophosphorylation; protein serine/threonine kinase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR010513; IPR011009; IPR018391; IPR000719; IPR006567; IPR027295; IPR011047; IPR008271; Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] Ern1 Ire1 Mus musculus (Mouse) TR25499_c0_g1_i1 A2VE52 ORN_BOVIN 8.00E-87 GO:0008408; GO:0005739; GO:0003676; GO:0090305; GO:0005730; GO:0005886 3'-5' exonuclease activity; mitochondrion; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis; nucleolus; plasma membrane IPR006055; IPR013520; IPR022894; IPR012337; "Oligoribonuclease, mitochondrial (EC 3.1.-.-) (RNA exonuclease 2 homolog) (Small fragment nuclease)" REXO2 Bos taurus (Bovine) TR25500_c1_g1_i1 Q3MHN0 PSB6_BOVIN 1.00E-90 GO:0005737; GO:0005634; GO:0005839; GO:0051603; GO:0004298 cytoplasm; nucleus; proteasome core complex; proteolysis involved in cellular protein catabolic process; threonine-type endopeptidase activity IPR000243; IPR016050; IPR001353; IPR023333; Proteasome subunit beta type-6 (EC 3.4.25.1) PSMB6 Bos taurus (Bovine) TR25502_c1_g1_i1 Q96HJ9 CG055_HUMAN 6.00E-24 GO:0005739 mitochondrion UPF0562 protein C7orf55 C7orf55 HSPC268 Homo sapiens (Human) TR25511_c0_g1_i1 A1X149 CAV1_ECHTE 2.00E-20 GO:0000139; GO:0031295; GO:0016324; GO:0097190; GO:0016323; GO:0005901; GO:0072584; GO:0071455; GO:0009267; GO:0031410; GO:0051480; GO:0005768; GO:0030514; GO:0090090; GO:0033137; GO:0032091; GO:0000122; GO:0010524; GO:0090263; GO:2001238; GO:2001244; GO:0033138; GO:2000286; GO:0030193; GO:0051592; GO:0032570; GO:0005198; GO:0016050 Golgi membrane; T cell costimulation; apical plasma membrane; apoptotic signaling pathway; basolateral plasma membrane; caveola; caveolin-mediated endocytosis; cellular response to hyperoxia; cellular response to starvation; cytoplasmic vesicle; cytosolic calcium ion homeostasis; endosome; negative regulation of BMP signaling pathway; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of peptidyl-serine phosphorylation; negative regulation of protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of calcium ion transport into cytosol; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of peptidyl-serine phosphorylation; receptor internalization involved in canonical Wnt receptor signaling pathway; regulation of blood coagulation; response to calcium ion; response to progesterone stimulus; structural molecule activity; vesicle organization IPR001612; IPR015504; IPR018361; Caveolin-1 CAV1 Echinops telfairi (Lesser hedgehog tenrec) TR25512_c1_g1_i1 P10073 ZSC22_HUMAN 6.00E-13 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 22 (Krueppel-related zinc finger protein 2) (Protein HKR2) (Zinc finger protein 50) ZSCAN22 HKR2 ZNF50 Homo sapiens (Human) TR25512_c1_g4_i1 Q61116 ZN235_MOUSE 4.00E-12 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 93) (Zfp-93) Znf235 Zfp93 Mus musculus (Mouse) TR25512_c1_g4_i2 Q49A33 Z876P_HUMAN 5.00E-13 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Putative zinc finger protein 876 ZNF876P Homo sapiens (Human) TR25516_c1_g1_i1 Q99707 METH_HUMAN 4.00E-101 GO:0034641; GO:0031419; GO:0009235; GO:0005829; GO:0008898; GO:0008705; GO:0032259; GO:0007399; GO:0042558; GO:0000096; GO:0006805; GO:0008270 Q15714 cellular nitrogen compound metabolic process; cobalamin binding; cobalamin metabolic process; cytosol; homocysteine S-methyltransferase activity; methionine synthase activity; methylation; nervous system development; pteridine-containing compound metabolic process; sulfur amino acid metabolic process; xenobiotic metabolic process; zinc ion binding IPR003759; IPR006158; IPR011005; IPR011822; IPR000489; IPR003726; IPR004223; Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1. Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Vitamin-B12 dependent methionine synthase) (MS) MTR Homo sapiens (Human) TR25516_c2_g1_i1 Q9I2Q2 METH_PSEAE 4.00E-73 GO:0006520; GO:0031419; GO:0008898; GO:0005622; GO:0008705; GO:0042558; GO:0008270 cellular amino acid metabolic process; cobalamin binding; homocysteine S-methyltransferase activity; intracellular; methionine synthase activity; pteridine-containing compound metabolic process; zinc ion binding IPR003759; IPR006158; IPR011005; IPR011822; IPR000489; IPR003726; IPR004223; Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1. "Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Methionine synthase, vitamin-B12 dependent) (MS)" metH PA1843 Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) TR25522_c0_g1_i1 Q6P2U9 CSN3_DANRE 0 GO:0008180; GO:0005737 COP9 signalosome; cytoplasm IPR000717; IPR011991; COP9 signalosome complex subunit 3 (Signalosome subunit 3) cops3 csn3 wu:fc32a02 Danio rerio (Zebrafish) (Brachydanio rerio) TR25525_c1_g1_i1 Q15751 HERC1_HUMAN 6.00E-98 GO:0005086; GO:0005794; GO:0021702; GO:0005829; GO:0016020; GO:0010507; GO:0050885; GO:0031175; GO:0006810; GO:0004842 ARF guanyl-nucleotide exchange factor activity; Golgi apparatus; cerebellar Purkinje cell differentiation; cytosol; membrane; negative regulation of autophagy; neuromuscular process controlling balance; neuron projection development; transport; ubiquitin-protein ligase activity IPR001870; IPR008985; IPR000569; IPR009091; IPR000408; IPR018355; IPR003877; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HERC1 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 1) (p532) (p619) HERC1 Homo sapiens (Human) TR25529_c5_g1_i1 P33945 WNT5B_XENLA 1.00E-143 GO:0016055; GO:0007275; GO:0005578 Wnt receptor signaling pathway; multicellular organismal development; proteinaceous extracellular matrix IPR005817; IPR026537; IPR018161; Protein Wnt-5b (Protein Wnt-5c) (XWnt-5C) wnt5b wnt5c Xenopus laevis (African clawed frog) TR25533_c0_g1_i1 Q66S64 MBL2_PONPY 2.00E-08 GO:0005581; GO:0006958; GO:0001867; GO:0005537 "collagen; complement activation, classical pathway; complement activation, lectin pathway; mannose binding" IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Mannose-binding protein C (MBP-C) (MBP1) (Mannan-binding protein) (Mannose-binding lectin) MBL2 Pongo pygmaeus (Bornean orangutan) TR25533_c0_g1_i2 P86854 PLCL_MYTGA 7.00E-41 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR25538_c0_g1_i1 Q4PM12 RL36_IXOSC 1.00E-40 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000509; 60S ribosomal protein L36 RpL36 Ixodes scapularis (Black-legged tick) (Deer tick) TR25539_c1_g1_i1 Q99542 MMP19_HUMAN 2.00E-24 GO:0001525; GO:0005509; GO:0030154; GO:0030574; GO:0022617; GO:0001554; GO:0004222; GO:0001541; GO:0001542; GO:0005578; GO:0006508; GO:0051591; GO:0009725; GO:0008270 angiogenesis; calcium ion binding; cell differentiation; collagen catabolic process; extracellular matrix disassembly; luteolysis; metalloendopeptidase activity; ovarian follicle development; ovulation from ovarian follicle; proteinaceous extracellular matrix; proteolysis; response to cAMP; response to hormone stimulus; zinc ion binding IPR000585; IPR018487; IPR024079; IPR001818; IPR021190; IPR016293; IPR006026; IPR002477; Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI) (Matrix metalloproteinase-18) (MMP-18) MMP19 MMP18 RASI Homo sapiens (Human) TR25540_c0_g1_i1 P28491 CALR_PIG 3.00E-150 GO:0042824; GO:0005509; GO:0030246; GO:0007050; GO:0090398; GO:0030866; GO:0005829; GO:0009897; GO:0005615; GO:0003729; GO:0033144; GO:0045665; GO:0048387; GO:0000122; GO:0002502; GO:0048471; GO:0005844; GO:0045740; GO:0045787; GO:0008284; GO:2000510; GO:0010628; GO:0050766; GO:1900026; GO:0006611; GO:0006457; GO:0034504; GO:0050821; GO:0040020; GO:0033018 MHC class I peptide loading complex; calcium ion binding; carbohydrate binding; cell cycle arrest; cellular senescence; cortical actin cytoskeleton organization; cytosol; external side of plasma membrane; extracellular space; mRNA binding; negative regulation of intracellular steroid hormone receptor signaling pathway; negative regulation of neuron differentiation; negative regulation of retinoic acid receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; peptide antigen assembly with MHC class I protein complex; perinuclear region of cytoplasm; polysome; positive regulation of DNA replication; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of dendritic cell chemotaxis; positive regulation of gene expression; positive regulation of phagocytosis; positive regulation of substrate adhesion-dependent cell spreading; protein export from nucleus; protein folding; protein localization to nucleus; protein stabilization; regulation of meiosis; sarcoplasmic reticulum lumen IPR001580; IPR018124; IPR009169; IPR009033; IPR008985; IPR013320; Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) CALR Sus scrofa (Pig) TR25541_c1_g1_i1 A8C756 THADA_MOUSE 2.00E-52 IPR011989; IPR016024; IPR019442; Thyroid adenoma-associated protein homolog Thada Kiaa1767 Mus musculus (Mouse) TR25542_c0_g1_i1 Q6GLJ1 BTBDH_XENLA 8.00E-33 GO:0005576 extracellular region IPR011705; IPR000210; IPR011333; IPR013069; BTB/POZ domain-containing protein 17 btbd17 Xenopus laevis (African clawed frog) TR25543_c3_g1_i1 Q7TN88 PK1L2_MOUSE 9.00E-18 GO:0005262; GO:0005509; GO:0030246; GO:0050982; GO:0016021; GO:0016020; GO:0007218 calcium channel activity; calcium ion binding; carbohydrate binding; detection of mechanical stimulus; integral to membrane; membrane; neuropeptide signaling pathway IPR001304; IPR016186; IPR016187; IPR000203; IPR000922; IPR008976; IPR022409; IPR002859; IPR013122; IPR003915; IPR000601; IPR001024; IPR014010; Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) Pkd1l2 Mus musculus (Mouse) TR25543_c6_g1_i1 Q2EG98 PK1L3_MOUSE 2.00E-13 GO:0005262; GO:0005509; GO:0030246; GO:0071468; GO:0001581; GO:0050982; GO:0016021; GO:0016020; GO:0007218 calcium channel activity; calcium ion binding; carbohydrate binding; cellular response to acidity; detection of chemical stimulus involved in sensory perception of sour taste; detection of mechanical stimulus; integral to membrane; membrane; neuropeptide signaling pathway IPR001304; IPR016186; IPR016187; IPR000203; IPR008976; IPR013122; IPR003915; IPR001024; Polycystic kidney disease protein 1-like 3 (PC1-like 3 protein) (Polycystin-1L3) Pkd1l3 71B10 Mus musculus (Mouse) TR25546_c0_g1_i1 Q8N5M1 ATPF2_HUMAN 1.00E-88 GO:0005739; GO:0016607; GO:0043461 mitochondrion; nuclear speck; proton-transporting ATP synthase complex assembly IPR011419; IPR023335; ATP synthase mitochondrial F1 complex assembly factor 2 (ATP12 homolog) ATPAF2 ATP12 LP3663 Homo sapiens (Human) TR25547_c1_g1_i1 Q9VED0 TAPT1_DROME 4.00E-33 GO:0016021 integral to membrane IPR008010; Protein TAPT1 homolog CG7218 Drosophila melanogaster (Fruit fly) TR25547_c2_g1_i1 O60067 TAPT1_SCHPO 1.00E-11 GO:0005794; GO:0005783; GO:0016021; GO:0005739; GO:0034975 Golgi apparatus; endoplasmic reticulum; integral to membrane; mitochondrion; protein folding in endoplasmic reticulum IPR008010; Protein TAPT1 homolog SPBC13G1.05 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR25547_c6_g1_i1 Q4VBD2 TAPT1_MOUSE 3.00E-42 GO:0048706; GO:0001701; GO:0016021; GO:0009791 embryonic skeletal system development; in utero embryonic development; integral to membrane; post-embryonic development IPR008010; Transmembrane anterior posterior transformation protein 1 Tapt1 Mus musculus (Mouse) TR25548_c1_g1_i1 Q95JD5 ST1B1_CANFA 1.00E-33 GO:0004062; GO:0005737; GO:0009812; GO:0008202; GO:0051923; GO:0042403; GO:0006805 aryl sulfotransferase activity; cytoplasm; flavonoid metabolic process; steroid metabolic process; sulfation; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (cSULT1B1) (EC 2.8.2.-) SULT1B1 ST1B2 Canis familiaris (Dog) (Canis lupus familiaris) TR25551_c2_g1_i1 Q6DE37 GXLT2_XENLA 5.00E-77 GO:0016266; GO:0035252; GO:0016021 O-glycan processing; UDP-xylosyltransferase activity; integral to membrane IPR002495; Glucoside xylosyltransferase 2 (EC 2.4.2.n2) (Glycosyltransferase 8 domain-containing protein 4) gxylt2 glt8d4 Xenopus laevis (African clawed frog) TR25553_c2_g2_i1 O83142 5NTD_TREPA 7.00E-29 GO:0008253; GO:0046872; GO:0000166; GO:0009166; GO:0005886 5'-nucleotidase activity; metal ion binding; nucleotide binding; nucleotide catabolic process; plasma membrane IPR008334; IPR006146; IPR006179; IPR006420; IPR004843; Probable 5'-nucleotidase (EC 3.1.3.5) TP_0104 Treponema pallidum (strain Nichols) TR25553_c3_g1_i1 Q61503 5NTD_MOUSE 6.00E-91 GO:0008253; GO:0006196; GO:0046086; GO:0031225; GO:0005737; GO:0070062; GO:0046872; GO:0050728; GO:0000166; GO:0005886 5'-nucleotidase activity; AMP catabolic process; adenosine biosynthetic process; anchored to membrane; cytoplasm; extracellular vesicular exosome; metal ion binding; negative regulation of inflammatory response; nucleotide binding; plasma membrane IPR008334; IPR006146; IPR006179; IPR004843; 5'-nucleotidase (5'-NT) (EC 3.1.3.5) (Ecto-5'-nucleotidase) (CD antigen CD73) Nt5e Nt5 Nte Mus musculus (Mouse) TR25555_c3_g3_i1 O77802 ANGP2_BOVIN 9.00E-15 GO:0048014; GO:0001525; GO:0030154; GO:0005615; GO:0046872; GO:0016525; GO:0043537; GO:0010812; GO:0050928 Tie signaling pathway; angiogenesis; cell differentiation; extracellular space; metal ion binding; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of cell-substrate adhesion; negative regulation of positive chemotaxis IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-2 (ANG-2) ANGPT2 ANG2 Bos taurus (Bovine) TR25557_c1_g3_i1 P14133 ASO_CUCSA 2.00E-28 GO:0008447; GO:0005507; GO:0005576 L-ascorbate oxidase activity; copper ion binding; extracellular region IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; IPR017760; L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) Cucumis sativus (Cucumber) TR25557_c2_g1_i1 Q9FLB5 LAC12_ARATH 2.00E-19 GO:0048046; GO:0005507; GO:0052716; GO:0046274 apoplast; copper ion binding; hydroquinone:oxygen oxidoreductase activity; lignin catabolic process IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; IPR017761; Laccase-12 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 12) (Diphenol oxidase 12) (Urishiol oxidase 12) LAC12 At5g05390 K18I23.20 Arabidopsis thaliana (Mouse-ear cress) TR25558_c0_g1_i1 P09057 DCOR_RAT 1.00E-145 GO:0005829; GO:0001822; GO:0004586; GO:0048471; GO:0008284; GO:0009446; GO:0033387; GO:0009615 cytosol; kidney development; ornithine decarboxylase activity; perinuclear region of cytoplasm; positive regulation of cell proliferation; putrescine biosynthetic process; putrescine biosynthetic process from ornithine; response to virus IPR009006; IPR022643; IPR022657; IPR022644; IPR022653; IPR000183; IPR002433; Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1. Ornithine decarboxylase (ODC) (EC 4.1.1.17) Odc1 Odc Rattus norvegicus (Rat) TR25558_c0_g1_i2 P09057 DCOR_RAT 1.00E-145 GO:0005829; GO:0001822; GO:0004586; GO:0048471; GO:0008284; GO:0009446; GO:0033387; GO:0009615 cytosol; kidney development; ornithine decarboxylase activity; perinuclear region of cytoplasm; positive regulation of cell proliferation; putrescine biosynthetic process; putrescine biosynthetic process from ornithine; response to virus IPR009006; IPR022643; IPR022657; IPR022644; IPR022653; IPR000183; IPR002433; Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1. Ornithine decarboxylase (ODC) (EC 4.1.1.17) Odc1 Odc Rattus norvegicus (Rat) TR25559_c0_g1_i1 B7QIN3 U608_IXOSC 2.00E-29 GO:0016021 integral to membrane Protein SMIM7 homolog ISCW013552 Ixodes scapularis (Black-legged tick) (Deer tick) TR25561_c0_g2_i1 Q75JF3 CLCC_DICDI 2.00E-34 GO:0030554; GO:0034707; GO:0005247 adenyl nucleotide binding; chloride channel complex; voltage-gated chloride channel activity IPR000644; IPR014743; IPR001807; Chloride channel protein C clcC DDB_G0276229 Dictyostelium discoideum (Slime mold) TR25562_c0_g1_i2 P15101 DOPO_BOVIN 1.00E-96 GO:0031418; GO:0034466; GO:0042584; GO:0005507; GO:0004500; GO:0016021; GO:0042421; GO:0030658 L-ascorbic acid binding; chromaffin granule lumen; chromaffin granule membrane; copper ion binding; dopamine beta-monooxygenase activity; integral to membrane; norepinephrine biosynthetic process; transport vesicle membrane IPR014784; IPR020611; IPR014783; IPR000323; IPR000945; IPR005018; IPR008977; Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1. Dopamine beta-hydroxylase (EC 1.14.17.1) (Dopamine beta-monooxygenase) [Cleaved into: Soluble dopamine beta-hydroxylase] DBH Bos taurus (Bovine) TR25563_c1_g1_i1 P58200 VTI1B_RAT 2.00E-18 GO:0005794; GO:0031201; GO:0016021; GO:0006886; GO:0031902; GO:0005765; GO:0016192 Golgi apparatus; SNARE complex; integral to membrane; intracellular protein transport; late endosome membrane; lysosomal membrane; vesicle-mediated transport IPR010989; IPR000727; IPR007705; Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1) Vti1b Vti1l1 Rattus norvegicus (Rat) TR25563_c1_g1_i2 Q96AJ9 VTI1A_HUMAN 9.00E-57 GO:0005794; GO:0000139; GO:0005484; GO:0031201; GO:0016023; GO:0016021; GO:0006886; GO:0042147 "Golgi apparatus; Golgi membrane; SNAP receptor activity; SNARE complex; cytoplasmic membrane-bounded vesicle; integral to membrane; intracellular protein transport; retrograde transport, endosome to Golgi" IPR010989; IPR000727; IPR007705; Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2) VTI1A Homo sapiens (Human) TR25566_c0_g1_i1 P42620 YQJG_ECOLI 2.00E-59 GO:0016491 oxidoreductase activity IPR010987; IPR004045; IPR016639; IPR012336; Glutathionyl-hydroquinone reductase YqjG (GS-HQR) (EC 1.8.-.-) yqjG b3102 JW3073 Escherichia coli (strain K12) TR25566_c1_g1_i1 O94524 GTO2_SCHPO 1.00E-42 GO:0005794; GO:0034599; GO:0005829; GO:0045174; GO:0004364; GO:0005634 Golgi apparatus; cellular response to oxidative stress; cytosol; glutathione dehydrogenase (ascorbate) activity; glutathione transferase activity; nucleus IPR010987; IPR004045; IPR016639; IPR012336; Glutathione S-transferase omega-like 2 (EC 2.5.1.18) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) gto2 SPCC1281.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR25567_c0_g1_i1 Q5RF01 LRC32_PONAB 6.00E-07 GO:0002755; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0009617; GO:0034170; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to bacterium; toll-like receptor 11 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR003591; IPR000372; IPR027194; Leucine-rich repeat-containing protein 32 LRRC32 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR25567_c1_g1_i1 P24014 SLIT_DROME 5.00E-17 GO:0035385; GO:0071666; GO:0016199; GO:0005509; GO:0048813; GO:0007502; GO:0035050; GO:0007427; GO:0008347; GO:0008406; GO:0008201; GO:0050929; GO:0046331; GO:0008078; GO:0001764; GO:0003151; GO:0005886; GO:0022409; GO:0005578; GO:2000274; GO:0007432 "Roundabout signaling pathway; Slit-Robo signaling complex; axon midline choice point recognition; calcium ion binding; dendrite morphogenesis; digestive tract mesoderm development; embryonic heart tube development; epithelial cell migration, open tracheal system; glial cell migration; gonad development; heparin binding; induction of negative chemotaxis; lateral inhibition; mesodermal cell migration; neuron migration; outflow tract morphogenesis; plasma membrane; positive regulation of cell-cell adhesion; proteinaceous extracellular matrix; regulation of epithelial cell migration, open tracheal system; salivary gland boundary specification" IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; IPR026906; Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) TR25568_c1_g2_i3 Q5E9B2 PAF_BOVIN 3.00E-10 GO:0006260; GO:0051297; GO:0003682; GO:0005634; GO:0048471; GO:0051726; GO:0009411; GO:0019985 DNA replication; centrosome organization; chromatin binding; nucleus; perinuclear region of cytoplasm; regulation of cell cycle; response to UV; translesion synthesis PCNA-associated factor (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) PAF Bos taurus (Bovine) TR25570_c0_g1_i1 Q5T6J7 GNTK_HUMAN 8.00E-18 GO:0005524; GO:0046177; GO:0005737; GO:0046316 ATP binding; D-gluconate catabolic process; cytoplasm; gluconokinase activity IPR027417; IPR000623; IPR006001; Carbohydrate acid metabolism; D-gluconate degradation. Probable gluconokinase (EC 2.7.1.12) (Gluconate kinase) IDNK C9orf103 Homo sapiens (Human) TR25570_c0_g2_i1 Q54PI5 GNTK_DICDI 8.00E-26 GO:0005524; GO:0046177; GO:0046316 ATP binding; D-gluconate catabolic process; gluconokinase activity IPR027417; IPR000623; IPR006001; Carbohydrate acid metabolism; D-gluconate degradation. Probable gluconokinase (EC 2.7.1.12) (Gluconate kinase) DDB_G0284557 Dictyostelium discoideum (Slime mold) TR25573_c2_g1_i2 O75161 NPHP4_HUMAN 1.00E-59 GO:0030036; GO:0016337; GO:0005911; GO:0005813; GO:0005929; GO:0005829; GO:0035329; GO:0016020; GO:0005932; GO:0060041; GO:0005198; GO:0005923; GO:0007632 actin cytoskeleton organization; cell-cell adhesion; cell-cell junction; centrosome; cilium; cytosol; hippo signaling cascade; membrane; microtubule basal body; retina development in camera-type eye; structural molecule activity; tight junction; visual behavior Nephrocystin-4 (Nephroretinin) NPHP4 KIAA0673 Homo sapiens (Human) TR25574_c3_g1_i1 O70451 MOT2_MOUSE 2.00E-08 GO:0016021; GO:0005886; GO:0015355; GO:0015293 integral to membrane; plasma membrane; secondary active monocarboxylate transmembrane transporter activity; symporter activity IPR027178; IPR011701; IPR020846; IPR016196; IPR004743; Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) Slc16a7 Mct2 Mus musculus (Mouse) TR25575_c1_g1_i1 Q9UIL4 KIF25_HUMAN 2.00E-102 GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0007018; GO:0000070; GO:0010507 ATP binding; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement; mitotic sister chromatid segregation; negative regulation of autophagy IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF25 (Kinesin-like protein 3) KIF25 KNSL3 Homo sapiens (Human) TR25575_c1_g1_i2 Q9UIL4 KIF25_HUMAN 4.00E-102 GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0007018; GO:0000070; GO:0010507 ATP binding; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement; mitotic sister chromatid segregation; negative regulation of autophagy IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF25 (Kinesin-like protein 3) KIF25 KNSL3 Homo sapiens (Human) TR25578_c1_g2_i1 Q96RW7 HMCN1_HUMAN 1.00E-25 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR25580_c0_g1_i1 P55864 PAX6_XENLA 2.00E-17 GO:0007275; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; IPR001523; IPR011991; Paired box protein Pax-6 pax6 Xenopus laevis (African clawed frog) TR25580_c0_g1_i2 A6NJT0 UNC4_HUMAN 4.00E-51 GO:0001502; GO:0035726; GO:0021516; GO:0005634; GO:0021889; GO:0007389; GO:0045595; GO:0043565; GO:0003700; GO:0006351 "cartilage condensation; common myeloid progenitor cell proliferation; dorsal spinal cord development; nucleus; olfactory bulb interneuron differentiation; pattern specification process; regulation of cell differentiation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; Homeobox protein unc-4 homolog (Homeobox protein Uncx4.1) UNCX UNCX4.1 Homo sapiens (Human) TR25580_c0_g1_i3 O08934 UNC4_MOUSE 4.00E-51 GO:0001502; GO:0035726; GO:0021516; GO:0005634; GO:0021889; GO:0007389; GO:0045595; GO:0010468; GO:0043565; GO:0003700; GO:0006351 "cartilage condensation; common myeloid progenitor cell proliferation; dorsal spinal cord development; nucleus; olfactory bulb interneuron differentiation; pattern specification process; regulation of cell differentiation; regulation of gene expression; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; Homeobox protein unc-4 homolog (Homeobox protein Uncx4.1) Uncx Uncx4.1 Mus musculus (Mouse) TR25580_c0_g1_i4 O08934 UNC4_MOUSE 3.00E-34 GO:0001502; GO:0035726; GO:0021516; GO:0005634; GO:0021889; GO:0007389; GO:0045595; GO:0010468; GO:0043565; GO:0003700; GO:0006351 "cartilage condensation; common myeloid progenitor cell proliferation; dorsal spinal cord development; nucleus; olfactory bulb interneuron differentiation; pattern specification process; regulation of cell differentiation; regulation of gene expression; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; Homeobox protein unc-4 homolog (Homeobox protein Uncx4.1) Uncx Uncx4.1 Mus musculus (Mouse) TR25582_c5_g1_i1 Q9H0F5 RNF38_HUMAN 4.00E-18 GO:0008270 zinc ion binding IPR001841; IPR013083; RING finger protein 38 RNF38 Homo sapiens (Human) TR25584_c0_g1_i2 Q9VCC3 RT24_DROME 1.00E-36 GO:0005762; GO:0005763; GO:0003735; GO:0006412 mitochondrial large ribosomal subunit; mitochondrial small ribosomal subunit; structural constituent of ribosome; translation IPR026146; "28S ribosomal protein S24, mitochondrial (MRP-S24) (S24mt)" mRpS24 CG13608 Drosophila melanogaster (Fruit fly) TR25585_c0_g1_i1 Q01797 ESCA_CALVI 1.00E-08 GO:0003677; GO:0046872; GO:0005634 DNA binding; metal ion binding; nucleus IPR007087; IPR015880; IPR013087; Escargot/snail protein homolog (Fragment) Calliphora vicina (Blue blowfly) (Calliphora erythrocephala) TR25585_c1_g1_i1 Q147U1 ZN846_HUMAN 5.00E-12 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 846 ZNF846 Homo sapiens (Human) TR25588_c2_g1_i1 P23414 ACH1_SCHGR 1.00E-15 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha-L1 Schistocerca gregaria (Desert locust) TR25588_c4_g2_i1 Q494W8 CRFM7_HUMAN 3.00E-07 GO:0005230; GO:0016021 extracellular ligand-gated ion channel activity; integral to membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; CHRNA7-FAM7A fusion protein (CHRNA7-DR1) (D-10) CHRFAM7A Homo sapiens (Human) TR25593_c1_g2_i1 Q9U6A1 PROS_DROVI 8.00E-70 GO:0003677; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR023082; IPR009057; IPR007738; Homeobox protein prospero pros Drosophila virilis (Fruit fly) TR25594_c0_g1_i1 Q5XGG3 PIHD2_XENTR 1.00E-38 IPR012981; PIH1 domain-containing protein 2 pih1d2 TNeu089n07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR25594_c0_g2_i1 Q7ZWY2 PIHD1_XENLA 3.00E-06 IPR012981; PIH1 domain-containing protein 1 pih1d1 Xenopus laevis (African clawed frog) TR25597_c0_g1_i2 Q9H8W5 TRI45_HUMAN 7.00E-06 GO:0060348; GO:0005737; GO:0005634; GO:0008270 bone development; cytoplasm; nucleus; zinc ion binding IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) TR25598_c3_g1_i1 P55302 AMRP_MOUSE 5.00E-32 GO:0009986; GO:1900116; GO:0005576; GO:0008201; GO:0050750; GO:1900222; GO:0032091; GO:0010916; GO:0005886; GO:0048237; GO:0031982 cell surface; extracellular negative regulation of signal transduction; extracellular region; heparin binding; low-density lipoprotein particle receptor binding; negative regulation of beta-amyloid clearance; negative regulation of protein binding; negative regulation of very-low-density lipoprotein particle clearance; plasma membrane; rough endoplasmic reticulum lumen; vesicle IPR010483; IPR009066; Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Heparin-binding protein 44) (HBP-44) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) Lrpap1 Mus musculus (Mouse) TR25599_c0_g1_i1 Q95KE5 RM43_BOVIN 2.00E-31 GO:0005739; GO:0005840 mitochondrion; ribosome IPR007741; IPR012336; "39S ribosomal protein L43, mitochondrial (L43mt) (MRP-L43) (Retina-specific 15.7 kDa protein)" MRPL43 Bos taurus (Bovine) TR25602_c0_g1_i1 Q5BJP5 TM230_RAT 5.00E-41 GO:0016021 integral to membrane IPR008590; Transmembrane protein 230 Tmem230 Rattus norvegicus (Rat) TR25604_c0_g1_i1 Q9GZ71 TPM_HALDV 2.00E-61 IPR000533; Tropomyosin Haliotis diversicolor (Abalone) (Sulculus diversicolor) TR25604_c0_g2_i3 Q9GZ71 TPM_HALDV 8.00E-141 IPR000533; Tropomyosin Haliotis diversicolor (Abalone) (Sulculus diversicolor) TR25606_c0_g1_i1 P63033 RHES_RAT 1.00E-41 GO:0005525; GO:0003924; GO:0007626; GO:0031397; GO:0005886; GO:0051897; GO:0033235; GO:0043949; GO:0007264; GO:0001963 "GTP binding; GTPase activity; locomotory behavior; negative regulation of protein ubiquitination; plasma membrane; positive regulation of protein kinase B signaling cascade; positive regulation of protein sumoylation; regulation of cAMP-mediated signaling; small GTPase mediated signal transduction; synaptic transmission, dopaminergic" IPR027417; IPR005225; IPR001806; IPR020849; GTP-binding protein Rhes (Ras homolog enriched in striatum) (SE6C) Rasd2 Rattus norvegicus (Rat) TR25608_c0_g1_i1 P62864 RS30_RAT 1.00E-21 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR006846; 40S ribosomal protein S30 Fau Rattus norvegicus (Rat) TR25609_c0_g2_i1 Q80VI1 TRI56_MOUSE 1.00E-06 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) TR25615_c0_g2_i1 Q6DFV8 VWDE_MOUSE 5.00E-11 GO:0005576 extracellular region IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) TR25616_c0_g1_i1 Q2KI79 ANRA2_BOVIN 2.00E-42 GO:0005856; GO:0005829; GO:0030169; GO:0016020; GO:0005634 cytoskeleton; cytosol; low-density lipoprotein particle binding; membrane; nucleus IPR002110; IPR020683; Ankyrin repeat family A protein 2 ANKRA2 Bos taurus (Bovine) TR25624_c0_g1_i1 P00533 EGFR_HUMAN 2.00E-14 GO:0005524; GO:0038095; GO:0000139; GO:0004709; GO:0070435; GO:0051015; GO:0043006; GO:0007202; GO:0007411; GO:0016323; GO:0008283; GO:0016337; GO:0071392; GO:0021795; GO:0003682; GO:0048546; GO:0003690; GO:0001892; GO:0030139; GO:0005789; GO:0005768; GO:0010008; GO:0005006; GO:0005615; GO:0008543; GO:0001942; GO:0045087; GO:0016021; GO:0045121; GO:0060571; GO:0043066; GO:0042059; GO:0042177; GO:0048011; GO:0031965; GO:0005634; GO:0001503; GO:0048471; GO:0048015; GO:0045739; GO:0045740; GO:0070374; GO:0043406; GO:0035413; GO:0030335; GO:0031659; GO:0050679; GO:0048146; GO:0045429; GO:0051897; GO:0045944; GO:0046777; GO:0046982; GO:0051205; GO:0004716; GO:0050999; GO:0050730; GO:0070141; GO:0007435 Itself; P42684; Q09666; Q02952; Q92625; Q96CW1; O00213; Q92870; O95704; Q9UKG1; P62158; P62161; P22681; P22682; Q7Z7G1; P46108; P46109; Q99418; Q6PKX4; P01133; P04626; P21860; Q15303; Q9UJM3; P03372; P03372-4; Q14318; P60520; P04406; P62993; Q9UBN7; P07900; P08238; P08107; P38646; P04792; P46940; O14654; P07948; P07948-1; Q9UQF2; Q13387; Q9Y2H9; P08581; O00750; P27986; O00459; Q92569; P19174; P16885; P18031; P20417; Q9UJ41; P20936; Q13671; Q01973; Q9UQQ2; P29353; P98077; P13866; P12931; P40763; P31948; P43405; Q9Y490; O75674; Q8K424; P09936; Q9P0L0; P27348; P63104 ATP binding; Fc-epsilon receptor signaling pathway; Golgi membrane; MAP kinase kinase kinase activity; Shc-EGFR complex; actin filament binding; activation of phospholipase A2 activity by calcium-mediated signaling; activation of phospholipase C activity; axon guidance; basolateral plasma membrane; cell proliferation; cell-cell adhesion; cellular response to estradiol stimulus; cerebral cortex cell migration; chromatin binding; digestive tract morphogenesis; double-stranded DNA binding; embryonic placenta development; endocytic vesicle; endoplasmic reticulum membrane; endosome; endosome membrane; epidermal growth factor-activated receptor activity; extracellular space; fibroblast growth factor receptor signaling pathway; hair follicle development; innate immune response; integral to membrane; membrane raft; morphogenesis of an epithelial fold; negative regulation of apoptotic process; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein catabolic process; neurotrophin TRK receptor signaling pathway; nuclear membrane; nucleus; ossification; perinuclear region of cytoplasm; phosphatidylinositol-mediated signaling; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAP kinase activity; positive regulation of catenin import into nucleus; positive regulation of cell migration; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of nitric oxide biosynthetic process; positive regulation of protein kinase B signaling cascade; positive regulation of transcription from RNA polymerase II promoter; protein autophosphorylation; protein heterodimerization activity; protein insertion into membrane; receptor signaling protein tyrosine kinase activity; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; response to UV-A; salivary gland morphogenesis IPR000494; IPR006211; IPR006212; IPR009030; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR016245; Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) EGFR ERBB ERBB1 HER1 Homo sapiens (Human) TR25625_c3_g1_i1 Q9Y2U5 M3K2_HUMAN 1.00E-61 GO:0005524; GO:0004709; GO:0007257; GO:0000186; GO:0071260; GO:0005737; GO:0046872; GO:0005634; GO:0045893; GO:0004674 Q9UNE7 "ATP binding; MAP kinase kinase kinase activity; activation of JUN kinase activity; activation of MAPKK activity; cellular response to mechanical stimulus; cytoplasm; metal ion binding; nucleus; positive regulation of transcription, DNA-dependent; protein serine/threonine kinase activity" IPR011009; IPR000270; IPR000719; IPR017441; IPR002290; Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) MAP3K2 MAPKKK2 MEKK2 Homo sapiens (Human) TR25625_c5_g1_i1 Q12469 SKM1_YEAST 3.00E-20 GO:0005524; GO:0000920; GO:0010629; GO:0005634; GO:0005543; GO:0005886; GO:0004674; GO:0035376 ATP binding; cytokinetic cell separation; negative regulation of gene expression; nucleus; phospholipid binding; plasma membrane; protein serine/threonine kinase activity; sterol import IPR000095; IPR011009; IPR011993; IPR001849; IPR000719; IPR002290; IPR008271; Serine/threonine-protein kinase SKM1 (EC 2.7.11.1) (Protein kinase 75490 D) SKM1 YOL113W HRA655 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR25627_c2_g1_i1 Q8VHE9 RETST_RAT 2.00E-13 GO:0051786; GO:0005789; GO:0005640 "all-trans-retinol 13,14-reductase activity; endoplasmic reticulum membrane; nuclear outer membrane" "All-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat) (PPAR-alpha-regulated and starvation-induced gene protein) (RMT-7)" Retsat Ppsig Rmt7 Rattus norvegicus (Rat) TR25627_c3_g1_i1 Q6NUM9 RETST_HUMAN 8.00E-24 GO:0051786; GO:0005789; GO:0005640 "all-trans-retinol 13,14-reductase activity; endoplasmic reticulum membrane; nuclear outer membrane" "All-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat) (PPAR-alpha-regulated and starvation-induced gene protein)" RETSAT PPSIG UNQ439/PRO872 Homo sapiens (Human) TR25628_c0_g2_i1 Q3UHD1 BAI1_MOUSE 1.00E-09 GO:0004930; GO:0016021; GO:0016525; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; negative regulation of angiogenesis; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR008077; IPR001879; IPR000832; IPR000203; IPR000884; Brain-specific angiogenesis inhibitor 1 Bai1 Mus musculus (Mouse) TR25629_c0_g1_i1 Q810B8 SLIK4_MOUSE 5.00E-08 GO:0007409; GO:0016021 axonogenesis; integral to membrane IPR000483; IPR001611; IPR003591; IPR000372; SLIT and NTRK-like protein 4 Slitrk4 Mus musculus (Mouse) TR25632_c1_g1_i2 Q6P7C4 LRC26_RAT 2.00E-16 GO:0005737; GO:0005856; GO:0006811; GO:0015459; GO:0008076 cytoplasm; cytoskeleton; ion transport; potassium channel regulator activity; voltage-gated potassium channel complex IPR000483; IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing protein 26 (BK channel auxiliary gamma subunit LRRC26) Lrrc26 Rattus norvegicus (Rat) TR25632_c1_g1_i3 P24014 SLIT_DROME 9.00E-20 GO:0035385; GO:0071666; GO:0016199; GO:0005509; GO:0048813; GO:0007502; GO:0035050; GO:0007427; GO:0008347; GO:0008406; GO:0008201; GO:0050929; GO:0046331; GO:0008078; GO:0001764; GO:0003151; GO:0005886; GO:0022409; GO:0005578; GO:2000274; GO:0007432 "Roundabout signaling pathway; Slit-Robo signaling complex; axon midline choice point recognition; calcium ion binding; dendrite morphogenesis; digestive tract mesoderm development; embryonic heart tube development; epithelial cell migration, open tracheal system; glial cell migration; gonad development; heparin binding; induction of negative chemotaxis; lateral inhibition; mesodermal cell migration; neuron migration; outflow tract morphogenesis; plasma membrane; positive regulation of cell-cell adhesion; proteinaceous extracellular matrix; regulation of epithelial cell migration, open tracheal system; salivary gland boundary specification" IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; IPR026906; Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) TR25634_c1_g1_i1 Q9Y399 RT02_HUMAN 3.00E-67 GO:0005739; GO:0015935; GO:0003735; GO:0006412 mitochondrion; small ribosomal subunit; structural constituent of ribosome; translation IPR001865; IPR005706; IPR018130; IPR023591; "28S ribosomal protein S2, mitochondrial (MRP-S2) (S2mt)" MRPS2 CGI-91 Homo sapiens (Human) TR25636_c0_g1_i1 Q3MHQ7 TM86A_BOVIN 9.00E-20 GO:0016021 integral to membrane IPR012506; Lysoplasmalogenase-like protein TMEM86A (Transmembrane protein 86A) TMEM86A Bos taurus (Bovine) TR25638_c0_g1_i1 Q2M3X9 ZN674_HUMAN 3.00E-14 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 674 ZNF674 Homo sapiens (Human) TR25638_c0_g2_i1 Q9P243 ZFAT_HUMAN 2.00E-25 GO:0003677; GO:0001077; GO:0005829; GO:0002244; GO:0046872; GO:0005634; GO:0060712 DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; cytosol; hematopoietic progenitor cell differentiation; metal ion binding; nucleus; spongiotrophoblast layer development IPR007087; IPR015880; IPR013087; Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) ZFAT KIAA1485 ZFAT1 ZNF406 Homo sapiens (Human) TR25638_c1_g2_i1 Q9NPA5 ZF64A_HUMAN 4.00E-13 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; "Zinc finger protein 64 homolog, isoforms 1 and 2 (Zfp-64) (Zinc finger protein 338)" ZFP64 ZNF338 Homo sapiens (Human) TR25638_c1_g3_i1 Q9P243 ZFAT_HUMAN 1.00E-57 GO:0003677; GO:0001077; GO:0005829; GO:0002244; GO:0046872; GO:0005634; GO:0060712 DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; cytosol; hematopoietic progenitor cell differentiation; metal ion binding; nucleus; spongiotrophoblast layer development IPR007087; IPR015880; IPR013087; Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) ZFAT KIAA1485 ZFAT1 ZNF406 Homo sapiens (Human) TR25640_c0_g1_i1 P83871 PHF5A_RAT 2.00E-62 GO:0003677; GO:0005689; GO:0005686; GO:0000398; GO:0016363; GO:0016607; GO:0045893; GO:0003700; GO:0006351 "DNA binding; U12-type spliceosomal complex; U2 snRNP; mRNA splicing, via spliceosome; nuclear matrix; nuclear speck; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR005345; PHD finger-like domain-containing protein 5A (PHD finger-like domain protein 5A) (Splicing factor 3B-associated 14 kDa protein) (SF3b14b) Phf5a Ini Rattus norvegicus (Rat) TR25641_c0_g1_i1 Q0R4F1 PIF1_XENLA 3.00E-173 GO:0005524; GO:0003677; GO:0032508; GO:0003678; GO:0006310; GO:0006281; GO:0005739; GO:0005634; GO:0000723 ATP binding; DNA binding; DNA duplex unwinding; DNA helicase activity; DNA recombination; DNA repair; mitochondrion; nucleus; telomere maintenance IPR003593; IPR003840; IPR010285; IPR027417; ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (DNA repair and recombination helicase PIF1) pif1 Xenopus laevis (African clawed frog) TR25643_c0_g1_i1 Q24K15 ANGP4_BOVIN 1.00E-47 GO:0001525; GO:0005576 angiogenesis; extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) TR25648_c0_g2_i1 Q63170 DYH7_RAT 4.00E-14 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0005509; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; calcium ion binding; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR026983; IPR026979; IPR024743; IPR024317; IPR004273; IPR013602; IPR018247; IPR002048; IPR027417; "Dynein heavy chain 7, axonemal (Axonemal beta dynein heavy chain 7) (Axonemal dynein heavy chain b) (Ciliary dynein heavy chain 7) (Dynein-like protein 7)" Dnah7 Axob Dlp7 Rattus norvegicus (Rat) TR25649_c2_g1_i1 Q5R546 ATPA_PONAB 0 GO:0005524; GO:0015991; GO:0015986; GO:0005753; GO:0005886; GO:0046933; GO:0045261; GO:0046961 "ATP binding; ATP hydrolysis coupled proton transport; ATP synthesis coupled proton transport; mitochondrial proton-transporting ATP synthase complex; plasma membrane; proton-transporting ATP synthase activity, rotational mechanism; proton-transporting ATP synthase complex, catalytic core F(1); proton-transporting ATPase activity, rotational mechanism" IPR020003; IPR023366; IPR005294; IPR000793; IPR000194; IPR004100; IPR027417; "ATP synthase subunit alpha, mitochondrial" ATP5A1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR25649_c2_g2_i1 B2S1S7 VATB_BORHD 3.00E-11 GO:0005524; GO:0042777; GO:0046933 "ATP binding; plasma membrane ATP synthesis coupled proton transport; proton-transporting ATP synthase activity, rotational mechanism" IPR000194; IPR004100; IPR027417; IPR022879; V-type ATP synthase beta chain (V-ATPase subunit B) atpB BH0093 Borrelia hermsii (strain HS1 / DAH) TR25649_c3_g1_i1 Q29596 ATPA2_PIG 1.00E-23 TR25655_c1_g1_i1 Q8BMG1 ATRIP_MOUSE 6.00E-12 GO:0006281; GO:0005634 Q9JKK8 DNA repair; nucleus ATR-interacting protein (ATM and Rad3-related-interacting protein) Atrip Mus musculus (Mouse) TR25656_c2_g1_i1 O75911 DHRS3_HUMAN 4.00E-35 GO:0052650; GO:0009055; GO:0016021; GO:0000166; GO:0042622; GO:0007603; GO:0042572; GO:0007601 "NADP-retinol dehydrogenase activity; electron carrier activity; integral to membrane; nucleotide binding; photoreceptor outer segment membrane; phototransduction, visible light; retinol metabolic process; visual perception" IPR002198; IPR002347; IPR016040; Short-chain dehydrogenase/reductase 3 (EC 1.1.1.300) (DD83.1) (Retinal short-chain dehydrogenase/reductase 1) (retSDR1) DHRS3 UNQ2424/PRO4983 Homo sapiens (Human) TR25656_c2_g1_i2 Q02338 BDH_HUMAN 8.00E-08 GO:0003858; GO:0060612; GO:0007420; GO:0044255; GO:0046951; GO:0046952; GO:0001889; GO:0005743; GO:0005759; GO:0005634; GO:0005543; GO:0046686; GO:0051412; GO:0042493; GO:0032355; GO:0045471; GO:0060416; GO:0032868; GO:0007584; GO:0042594; GO:0009636 3-hydroxybutyrate dehydrogenase activity; adipose tissue development; brain development; cellular lipid metabolic process; ketone body biosynthetic process; ketone body catabolic process; liver development; mitochondrial inner membrane; mitochondrial matrix; nucleus; phospholipid binding; response to cadmium ion; response to corticosterone stimulus; response to drug; response to estradiol stimulus; response to ethanol; response to growth hormone stimulus; response to insulin stimulus; response to nutrient; response to starvation; response to toxic substance IPR002198; IPR002347; IPR016040; IPR020904; "D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase)" BDH1 BDH Homo sapiens (Human) TR25658_c0_g1_i1 Q9Y4D1 DAAM1_HUMAN 7.00E-08 GO:0030036; GO:0005737; GO:0005886; GO:0001725 Itself; Q5T0N5; P61586; P00523; Q15642-2 actin cytoskeleton organization; cytoplasm; plasma membrane; stress fiber IPR011989; IPR016024; IPR027650; IPR014767; IPR015425; IPR010472; IPR010473; IPR014768; Disheveled-associated activator of morphogenesis 1 DAAM1 KIAA0666 Homo sapiens (Human) TR25658_c1_g1_i1 Q8BPM0 DAAM1_MOUSE 2.00E-128 GO:0030036; GO:0005737; GO:0005886; GO:0001725 O15085-2 actin cytoskeleton organization; cytoplasm; plasma membrane; stress fiber IPR011989; IPR016024; IPR027650; IPR014767; IPR015425; IPR010472; IPR010473; IPR014768; Disheveled-associated activator of morphogenesis 1 Daam1 Mus musculus (Mouse) TR25659_c0_g2_i1 Q9QUN7 TLR2_MOUSE 1.00E-13 GO:0002755; GO:0035354; GO:0035355; GO:0002752; GO:0071221; GO:0071223; GO:0071224; GO:0042892; GO:0050830; GO:0042498; GO:0009897; GO:0052063; GO:0006954; GO:0045087; GO:0016021; GO:0070891; GO:0044130; GO:0032695; GO:0032700; GO:0030670; GO:0032722; GO:0050715; GO:0050729; GO:0032728; GO:0032735; GO:0032741; GO:0032755; GO:0002687; GO:0060907; GO:0045429; GO:0051770; GO:0045944; GO:0042535; GO:0032760; GO:0046982; GO:0002238; GO:0034134; GO:0004888; GO:0042497 MyD88-dependent toll-like receptor signaling pathway; Toll-like receptor 1-Toll-like receptor 2 protein complex; Toll-like receptor 2-Toll-like receptor 6 protein complex; cell surface pattern recognition receptor signaling pathway; cellular response to bacterial lipopeptide; cellular response to lipoteichoic acid; cellular response to peptidoglycan; chloramphenicol transport; defense response to Gram-positive bacterium; diacyl lipopeptide binding; external side of plasma membrane; induction by symbiont of defense-related host nitric oxide production; inflammatory response; innate immune response; integral to membrane; lipoteichoic acid binding; negative regulation of growth of symbiont in host; negative regulation of interleukin-12 production; negative regulation of interleukin-17 production; phagocytic vesicle membrane; positive regulation of chemokine production; positive regulation of cytokine secretion; positive regulation of inflammatory response; positive regulation of interferon-beta production; positive regulation of interleukin-12 production; positive regulation of interleukin-18 production; positive regulation of interleukin-6 production; positive regulation of leukocyte migration; positive regulation of macrophage cytokine production; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of tumor necrosis factor production; protein heterodimerization activity; response to molecule of fungal origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity; triacyl lipopeptide binding IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) Tlr2 Mus musculus (Mouse) TR25659_c0_g3_i1 O60602 TLR5_HUMAN 5.00E-13 GO:0002755; GO:0071260; GO:0006954; GO:0045087; GO:0016021; GO:0005886; GO:0032757; GO:0034123; GO:0034166; GO:0034146 MyD88-dependent toll-like receptor signaling pathway; cellular response to mechanical stimulus; inflammatory response; innate immune response; integral to membrane; plasma membrane; positive regulation of interleukin-8 production; positive regulation of toll-like receptor signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway IPR000483; IPR001611; IPR003591; IPR000157; Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3) TLR5 TIL3 Homo sapiens (Human) TR25663_c3_g1_i1 P55212 CASP6_HUMAN 1.00E-06 GO:0006921; GO:0004197; GO:0005829; GO:0005654; GO:0006508 Itself; Q01826 cellular component disassembly involved in execution phase of apoptosis; cysteine-type endopeptidase activity; cytosol; nucleoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11] CASP6 MCH2 Homo sapiens (Human) TR25663_c3_g2_i1 P55210 CASP7_HUMAN 2.00E-07 GO:0008635; GO:0004190; GO:0006921; GO:0004197; GO:0005829; GO:0007507; GO:0097193; GO:0005654; GO:0043525; GO:0016485; GO:0006508; GO:0001836; GO:0009411 Q13490; Q13177; P17405; P98170 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; aspartic-type endopeptidase activity; cellular component disassembly involved in execution phase of apoptosis; cysteine-type endopeptidase activity; cytosol; heart development; intrinsic apoptotic signaling pathway; nucleoplasm; positive regulation of neuron apoptotic process; protein processing; proteolysis; release of cytochrome c from mitochondria; response to UV IPR015471; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Homo sapiens (Human) TR25665_c1_g1_i1 O17185 SUP9_CAEEL 6.00E-16 GO:0005887; GO:0036195; GO:0005267; GO:0006937; GO:0055120 integral to plasma membrane; muscle cell projection membrane; potassium channel activity; regulation of muscle contraction; striated muscle dense body IPR003280; IPR013099; IPR003092; Two pore potassium channel protein sup-9 (Suppressor of unc-93 protein 9) (n2P38) sup-9 F34D6.3 Caenorhabditis elegans TR25666_c0_g1_i1 P91924 ARF_DUGJA 4.00E-97 GO:0005525; GO:0005794; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor Dugesia japonica (Planarian) TR25667_c0_g1_i1 Q9NZ56 FMN2_HUMAN 1.00E-42 GO:0003779; GO:0005938; GO:0071456; GO:0030659; GO:0005856; GO:0005829; GO:0051295; GO:0070649; GO:0051758; GO:0035556; GO:0046907; GO:0007275; GO:0043066; GO:0042177; GO:0005730; GO:0048477; GO:0048471; GO:0005886; GO:0040038; GO:0015031; GO:0006974; GO:0016192 actin binding; cell cortex; cellular response to hypoxia; cytoplasmic vesicle membrane; cytoskeleton; cytosol; establishment of meiotic spindle localization; formin-nucleated actin cable assembly; homologous chromosome movement towards spindle pole involved in homologous chromosome segregation; intracellular signal transduction; intracellular transport; multicellular organismal development; negative regulation of apoptotic process; negative regulation of protein catabolic process; nucleolus; oogenesis; perinuclear region of cytoplasm; plasma membrane; polar body extrusion after meiotic divisions; protein transport; response to DNA damage stimulus; vesicle-mediated transport IPR000591; IPR015425; IPR009408; Formin-2 FMN2 Homo sapiens (Human) TR25669_c0_g1_i1 O75367 H2AY_HUMAN 7.00E-07 GO:0001740; GO:0003677; GO:0003682; GO:0016568; GO:0000793; GO:0007549; GO:0000786; GO:0006334 P04626 Barr body; DNA binding; chromatin binding; chromatin modification; condensed chromosome; dosage compensation; nucleosome; nucleosome assembly IPR021171; IPR009072; IPR007125; IPR002119; IPR002589; Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205) H2AFY MACROH2A1 Homo sapiens (Human) TR25672_c0_g1_i1 Q54NF8 SCAR_DICDI 7.00E-07 GO:0031209; GO:0030036; GO:0005938; GO:0016049; GO:0060187; GO:0005911; GO:0031589; GO:0043327; GO:0005856; GO:0006887; GO:0032433; GO:0000281; GO:0043148; GO:0006909; GO:0006907; GO:0030838; GO:0031143; GO:0031269; GO:0001726; GO:0031288 Q55FT9; Q54X65 SCAR complex; actin cytoskeleton organization; cell cortex; cell growth; cell pole; cell-cell junction; cell-substrate adhesion; chemotaxis to cAMP; cytoskeleton; exocytosis; filopodium tip; mitotic cytokinesis; mitotic spindle stabilization; phagocytosis; pinocytosis; positive regulation of actin filament polymerization; pseudopodium; pseudopodium assembly; ruffle; sorocarp morphogenesis IPR028288; IPR003124; Protein SCAR (Suppressor of cAMP receptor) scrA DDB_G0285253 Dictyostelium discoideum (Slime mold) TR25672_c2_g1_i1 Q9UPY6 WASF3_HUMAN 4.00E-15 GO:0030041; GO:0005737; GO:0005856; GO:0030027; GO:0030032; GO:0014003; GO:0031643; GO:0008360 actin filament polymerization; cytoplasm; cytoskeleton; lamellipodium; lamellipodium assembly; oligodendrocyte development; positive regulation of myelination; regulation of cell shape IPR028288; IPR003124; Wiskott-Aldrich syndrome protein family member 3 (WASP family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3) WASF3 KIAA0900 SCAR3 WAVE3 Homo sapiens (Human) TR25674_c0_g2_i1 Q969T3 SNX21_HUMAN 1.00E-31 GO:0007154; GO:0030659; GO:0035091; GO:0015031 cell communication; cytoplasmic vesicle membrane; phosphatidylinositol binding; protein transport IPR001683; IPR011990; Sorting nexin-21 (Sorting nexin L) (SNX-L) SNX21 C20orf161 SNXL Homo sapiens (Human) TR25676_c1_g1_i1 Q04211 BTG2_MOUSE 1.00E-42 GO:0001077; GO:0009952; GO:0008306; GO:0021954; GO:0021542; GO:0043066; GO:2000178; GO:0017148; GO:0031175; GO:0060213; GO:0006479; GO:0006974; GO:0051602; GO:0009612; GO:0014070; GO:0043434; GO:0035914 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; anterior/posterior pattern specification; associative learning; central nervous system neuron development; dentate gyrus development; negative regulation of apoptotic process; negative regulation of neural precursor cell proliferation; negative regulation of translation; neuron projection development; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; protein methylation; response to DNA damage stimulus; response to electrical stimulus; response to mechanical stimulus; response to organic cyclic compound; response to peptide hormone stimulus; skeletal muscle cell differentiation IPR002087; Protein BTG2 (BTG family member 2) (NGF-inducible protein TIS21) Btg2 Tis21 Mus musculus (Mouse) TR2568_c1_g1_i1 Q6TCH7 PAQR3_HUMAN 2.00E-12 GO:0000139; GO:0016021 Golgi membrane; integral to membrane IPR004254; Progestin and adipoQ receptor family member 3 (Progestin and adipoQ receptor family member III) (Raf kinase trapping to Golgi) (RKTG) PAQR3 Homo sapiens (Human) TR25683_c0_g1_i1 Q9VUN3 RANL_DROME 3.00E-21 GO:0005525; GO:0003924; GO:0005737; GO:0006886; GO:0006913; GO:0005634; GO:0007264 GTP binding; GTPase activity; cytoplasm; intracellular protein transport; nucleocytoplasmic transport; nucleus; small GTPase mediated signal transduction IPR027417; IPR002041; IPR005225; IPR001806; GTP-binding nuclear protein Ran-like ran-like CG7815 Drosophila melanogaster (Fruit fly) TR25683_c0_g2_i1 Q05974 RAB1A_LYMST 4.00E-133 GO:0005525; GO:0005794; GO:0005783; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; endoplasmic reticulum; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-1A RAB1A Lymnaea stagnalis (Great pond snail) TR25687_c3_g1_i3 Q3UES3 TNKS2_MOUSE 1.00E-07 GO:0000139; GO:0003950; GO:0016055; GO:0000781; GO:0046872; GO:0035264; GO:0005635; GO:0000242; GO:0048471; GO:0090263; GO:0070213; GO:0070198; GO:0000209; GO:0040014; GO:0000723 "Golgi membrane; NAD+ ADP-ribosyltransferase activity; Wnt receptor signaling pathway; chromosome, telomeric region; metal ion binding; multicellular organism growth; nuclear envelope; pericentriolar material; perinuclear region of cytoplasm; positive regulation of canonical Wnt receptor signaling pathway; protein auto-ADP-ribosylation; protein localization to chromosome, telomeric region; protein polyubiquitination; regulation of multicellular organism growth; telomere maintenance" IPR002110; IPR020683; IPR012317; IPR001660; IPR013761; IPR011510; Tankyrase-2 (TANK2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) Tnks2 Tank2 Mus musculus (Mouse) TR25689_c1_g1_i1 P14381 YTX2_XENLA 9.00E-39 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR25692_c1_g1_i1 Q16609 LPAL2_HUMAN 5.00E-14 GO:0005576 extracellular region IPR000001; IPR013806; IPR018056; Putative apolipoprotein(a)-like protein 2 (Apo(a)-like protein 2) (Lp(a)-liker protein 2) (Apolipoprotein a-related gene C protein) (Apo(a)rg-C) LPAL2 APOARGC Homo sapiens (Human) TR25699_c4_g1_i2 Q6XHB2 ROCO4_DICDI 3.00E-06 GO:0005524; GO:0005525; GO:0005829; GO:0004672; GO:0004674; GO:0031153; GO:0007264; GO:0031150 ATP binding; GTP binding; cytosol; protein kinase activity; protein serine/threonine kinase activity; slug development involved in sorocarp development; small GTPase mediated signal transduction; sorocarp stalk development IPR011009; IPR001611; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR001245; IPR015943; IPR001680; IPR017986; Probable serine/threonine-protein kinase roco4 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 4) roco4 DDB_G0288251 Dictyostelium discoideum (Slime mold) TR25702_c1_g1_i2 Q9BYN0 SRXN1_HUMAN 4.00E-47 GO:0005524; GO:0005829; GO:0016667; GO:0006979; GO:0032542 "ATP binding; cytosol; oxidoreductase activity, acting on a sulfur group of donors; response to oxidative stress; sulfiredoxin activity" IPR003115; IPR016692; Sulfiredoxin-1 (EC 1.8.98.2) SRXN1 C20orf139 SRX Homo sapiens (Human) TR25705_c0_g1_i1 Q8BNA6 FAT3_MOUSE 3.00E-48 GO:0005509; GO:0007156; GO:0016021; GO:0007275; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; multicellular organismal development; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Protocadherin Fat 3 (FAT tumor suppressor homolog 3) Fat3 Gm1132 Gm510 Mus musculus (Mouse) TR25705_c0_g1_i2 Q9V5N8 STAN_DROME 2.00E-29 GO:0004930; GO:0007464; GO:0048057; GO:0016055; GO:0007411; GO:0005509; GO:0016339; GO:0050839; GO:0005911; GO:0048813; GO:0070593; GO:0007156; GO:0005887; GO:0016319; GO:0030178; GO:0007218; GO:0016318; GO:0030177; GO:0005057; GO:0050770; GO:0090175; GO:0051963; GO:0035159; GO:0007367; GO:0004888 P18537 "G-protein coupled receptor activity; R3/R4 cell fate commitment; R3/R4 development; Wnt receptor signaling pathway; axon guidance; calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; cell-cell junction; dendrite morphogenesis; dendrite self-avoidance; homophilic cell adhesion; integral to plasma membrane; mushroom body development; negative regulation of Wnt receptor signaling pathway; neuropeptide signaling pathway; ommatidial rotation; positive regulation of Wnt receptor signaling pathway; receptor signaling protein activity; regulation of axonogenesis; regulation of establishment of planar polarity; regulation of synapse assembly; regulation of tube length, open tracheal system; segment polarity determination; transmembrane signaling receptor activity" IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR001881; IPR013032; IPR002049; IPR017981; IPR001879; IPR000832; IPR000203; IPR001791; Protocadherin-like wing polarity protein stan (Protein flamingo) (Protein starry night) stan fmi CG11895 Drosophila melanogaster (Fruit fly) TR25705_c1_g1_i1 Q9VW71 FAT2_DROME 1.00E-51 GO:0009925; GO:0005509; GO:0016339; GO:0050839; GO:0050829; GO:0042247; GO:0030950; GO:0005925; GO:0007440; GO:0007295; GO:0007442; GO:0007156; GO:0005887; GO:0045571; GO:0007424; GO:0045089; GO:0004872; GO:0007431 basal plasma membrane; calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; defense response to Gram-negative bacterium; establishment of planar polarity of follicular epithelium; establishment or maintenance of actin cytoskeleton polarity; focal adhesion; foregut morphogenesis; growth of a germarium-derived egg chamber; hindgut morphogenesis; homophilic cell adhesion; integral to plasma membrane; negative regulation of imaginal disc growth; open tracheal system development; positive regulation of innate immune response; receptor activity; salivary gland development IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Fat-like cadherin-related tumor suppressor homolog (Protein kugelei) kug fat2 CG7749 Drosophila melanogaster (Fruit fly) TR25707_c8_g1_i1 Q9TU34 ITPR1_BOVIN 1.00E-27 GO:0005789; GO:0005220; GO:0016021; GO:0005218; GO:0070059; GO:0035091; GO:0051209; GO:0030658 "endoplasmic reticulum membrane; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; integral to membrane; intracellular ligand-gated calcium channel activity; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; phosphatidylinositol binding; release of sequestered calcium ion into cytosol; transport vesicle membrane" IPR016024; IPR000699; IPR014821; IPR000493; IPR005821; IPR016093; IPR013662; IPR015925; "Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)" ITPR1 Bos taurus (Bovine) TR25707_c8_g1_i2 Q9TU34 ITPR1_BOVIN 8.00E-28 GO:0005789; GO:0005220; GO:0016021; GO:0005218; GO:0070059; GO:0035091; GO:0051209; GO:0030658 "endoplasmic reticulum membrane; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; integral to membrane; intracellular ligand-gated calcium channel activity; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; phosphatidylinositol binding; release of sequestered calcium ion into cytosol; transport vesicle membrane" IPR016024; IPR000699; IPR014821; IPR000493; IPR005821; IPR016093; IPR013662; IPR015925; "Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)" ITPR1 Bos taurus (Bovine) TR25709_c0_g1_i1 P42297 YXIE_BACSU 3.00E-12 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein YxiE (USP YxiE) yxiE BSU39250 N17E Bacillus subtilis (strain 168) TR25710_c0_g1_i1 Q5XGL1 CENPK_XENLA 2.00E-18 GO:0000777; GO:0005634 condensed chromosome kinetochore; nucleus IPR020993; Centromere protein K (CENP-K) cenpk Xenopus laevis (African clawed frog) TR25711_c0_g1_i1 Q7JUR5 Y2744_DROME 9.00E-06 GO:0003677; GO:0050832; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; defense response to fungus; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Uncharacterized zinc finger protein CG12744 CG12744 Drosophila melanogaster (Fruit fly) TR25711_c1_g1_i1 Q61116 ZN235_MOUSE 2.00E-19 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 93) (Zfp-93) Znf235 Zfp93 Mus musculus (Mouse) TR25711_c2_g2_i1 O08961 ZN423_RAT 7.00E-38 GO:0007219; GO:0030154; GO:0046872; GO:0045892; GO:0007399; GO:0005634; GO:0030513; GO:0045893; GO:0042803; GO:0043565; GO:0006351 "Notch signaling pathway; cell differentiation; metal ion binding; negative regulation of transcription, DNA-dependent; nervous system development; nucleus; positive regulation of BMP signaling pathway; positive regulation of transcription, DNA-dependent; protein homodimerization activity; sequence-specific DNA binding; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 423 (Olf1/EBF-associated zinc finger protein) (rOAZ) (Smad- and Olf-interacting zinc finger protein) Znf423 Oaz Zfp423 Rattus norvegicus (Rat) TR25711_c4_g1_i1 Q6NUD7 ZN521_XENLA 9.00E-25 GO:0003677; GO:0030154; GO:0046872; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cell differentiation; metal ion binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; IPR013083; Zinc finger protein 521 znf521 Xenopus laevis (African clawed frog) TR25711_c5_g1_i1 O88939 ZBT7A_MOUSE 5.00E-13 GO:0003677; GO:0051216; GO:0030154; GO:0046872; GO:0000122; GO:0005634; GO:0006351 O09106 "DNA binding; cartilage development; cell differentiation; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma-related factor) (POZ and Krueppel erythroid myeloid ontogenic factor) (POK erythroid myeloid ontogenic factor) (Pokemon) Zbtb7a Lrf Zbtb7 Mus musculus (Mouse) TR25711_c5_g1_i2 Q9UTM0 YIV2_SCHPO 9.00E-06 GO:0003677; GO:0006281; GO:0031011; GO:0016568; GO:0005829; GO:0046872; GO:0006357; GO:0006351 "DNA binding; DNA repair; Ino80 complex; chromatin modification; cytosol; metal ion binding; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; INO80 complex subunit 1 iec1 SPAC144.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR25713_c0_g1_i1 Q9FWW6 GSXL1_ARATH 1.00E-28 GO:0004499; GO:0050661; GO:0050660 "N,N-dimethylaniline monooxygenase activity; NADP binding; flavin adenine dinucleotide binding" IPR000960; IPR020946; Flavin-containing monooxygenase FMO GS-OX-like 1 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 1) At1g12160 T28K15.10 Arabidopsis thaliana (Mouse-ear cress) TR25713_c1_g2_i1 P49109 FMO5_CAVPO 2.00E-100 GO:0004499; GO:0050661; GO:0005789; GO:0050660; GO:0016021 "N,N-dimethylaniline monooxygenase activity; NADP binding; endoplasmic reticulum membrane; flavin adenine dinucleotide binding; integral to membrane" IPR012143; IPR000960; IPR020946; IPR002257; IPR016040; Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5) FMO5 Cavia porcellus (Guinea pig) TR25714_c0_g1_i1 Q8QFV0 KCNT1_CHICK 7.00E-30 GO:0015269; GO:0005249; GO:0008076 calcium-activated potassium channel activity; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR013099; IPR003929; IPR016040; Potassium channel subfamily T member 1 (Sequence like a calcium-activated potassium channel subunit) KCNT1 SLACK Gallus gallus (Chicken) TR25719_c0_g2_i1 Q5ZLS8 INT10_CHICK 7.00E-94 GO:0005737; GO:0032039; GO:0016180 cytoplasm; integrator complex; snRNA processing IPR026164; Integrator complex subunit 10 (Int10) INTS10 RCJMB04_4p16 Gallus gallus (Chicken) TR25720_c0_g1_i2 Q6IP57 F00BA_XENLA 3.00E-13 IPR009060; UBA-like domain-containing protein 2-A ubald2-a fam100b-a Xenopus laevis (African clawed frog) TR25722_c0_g1_i1 Q5THR3 EFCB6_HUMAN 3.00E-20 GO:0005509; GO:0005634; GO:0006355; GO:0006351 "calcium ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011992; IPR018247; IPR015070; IPR002048; EF-hand calcium-binding domain-containing protein 6 (CAP-binding protein complex-interacting protein 1) (DJ-1-binding protein) (DJBP) EFCAB6 DJBP KIAA1672 Homo sapiens (Human) TR25722_c2_g1_i1 Q5RE62 EFCB6_PONAB 2.00E-11 GO:0005509; GO:0005634; GO:0006355; GO:0006351 "calcium ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011992; IPR018247; IPR002048; EF-hand calcium-binding domain-containing protein 6 (DJ-1-binding protein) (DJBP) EFCAB6 DJBP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR25723_c0_g3_i1 Q10KF0 PSA2_ORYSJ 2.00E-77 GO:0005737; GO:0005634; GO:0019773; GO:0004298; GO:0006511 "cytoplasm; nucleus; proteasome core complex, alpha-subunit complex; threonine-type endopeptidase activity; ubiquitin-dependent protein catabolic process" IPR000426; IPR023332; IPR001353; Proteasome subunit alpha type-2 (EC 3.4.25.1) (20S proteasome alpha subunit B) (20S proteasome subunit alpha-2) PAB1 Os03g0387100 LOC_Os03g26970 OSJNBb0058G04.11 Oryza sativa subsp. japonica (Rice) TR25723_c0_g3_i2 P24495 PSA2_XENLA 2.00E-96 GO:0005737; GO:0005634; GO:0005839; GO:0019773; GO:0004298; GO:0006511 "cytoplasm; nucleus; proteasome core complex; proteasome core complex, alpha-subunit complex; threonine-type endopeptidase activity; ubiquitin-dependent protein catabolic process" IPR000426; IPR023332; IPR001353; Proteasome subunit alpha type-2 (EC 3.4.25.1) (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (xC3) (Proteasome component C3) psma2 Xenopus laevis (African clawed frog) TR25723_c0_g3_i3 P21243 PSA6_YEAST 3.00E-19 GO:0042175; GO:0005634; GO:0043161; GO:0010499; GO:0019773; GO:0034515; GO:0004298 P21242; P23639 "nuclear outer membrane-endoplasmic reticulum membrane network; nucleus; proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; proteasome core complex, alpha-subunit complex; proteasome storage granule; threonine-type endopeptidase activity" IPR000426; IPR023332; IPR001353; Proteasome subunit alpha type-1 (EC 3.4.25.1) (Macropain subunit C7-alpha) (Multicatalytic endopeptidase complex C7) (Proteasome component C7-alpha) (Proteasome component Y8) (Proteinase YSCE subunit 7) (SCL1 suppressor protein) SCL1 PRC2 PRS2 YGL011C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR25725_c0_g1_i1 Q8IS44 DRD2L_DROME 3.00E-47 GO:0008227; GO:0004952; GO:0016021; GO:0005887 G-protein coupled amine receptor activity; dopamine neurotransmitter receptor activity; integral to membrane; integral to plasma membrane IPR000929; IPR000276; IPR017452; Dopamine D2-like receptor (DD2R) D2R CG17004 Drosophila melanogaster (Fruit fly) TR25725_c1_g1_i1 P28286 5HT2B_DROME 1.00E-17 GO:0001586; GO:0007198; GO:0009649; GO:0016021; GO:0007208; GO:0005886 Gi/o-coupled serotonin receptor activity; adenylate cyclase-inhibiting serotonin receptor signaling pathway; entrainment of circadian clock; integral to membrane; phospholipase C-activating serotonin receptor signaling pathway; plasma membrane IPR000276; IPR017452; 5-hydroxytryptamine receptor 2B (5-HT receptor 2B) (5-hydroxytryptamine receptor 1B) (5-HT receptor 1B) (Serotonin receptor 1B) (Serotonin receptor 2B) 5-HT1B 5HT-R2B CG15113 Drosophila melanogaster (Fruit fly) TR25726_c1_g1_i2 Q9I9H8 APAF_DANRE 4.00E-07 GO:0043531; GO:0005524; GO:0006915; GO:0005737; GO:0006952; GO:0042981 ADP binding; ATP binding; apoptotic process; cytoplasm; defense response; regulation of apoptotic process IPR017251; IPR001315; IPR011029; IPR000767; IPR020472; IPR002182; IPR027417; IPR015943; IPR001680; IPR019775; IPR017986; Apoptotic protease-activating factor 1 (APAF-1) apaf1 Danio rerio (Zebrafish) (Brachydanio rerio) TR25729_c0_g1_i1 Q64337 SQSTM_MOUSE 6.00E-46 GO:0070530; GO:0042169; GO:0016235; GO:0006915; GO:0005776; GO:0030154; GO:0000932; GO:0031410; GO:0005783; GO:0042802; GO:0005770; GO:0005764; GO:0016236; GO:0005634; GO:0000407; GO:0005080; GO:0043122; GO:0003712; GO:0008270 Q14145; Q9Z2X8; Q9GZQ8; Q9WVS7 K63-linked polyubiquitin binding; SH2 domain binding; aggresome; apoptotic process; autophagic vacuole; cell differentiation; cytoplasmic mRNA processing body; cytoplasmic vesicle; endoplasmic reticulum; identical protein binding; late endosome; lysosome; macroautophagy; nucleus; pre-autophagosomal structure; protein kinase C binding; regulation of I-kappaB kinase/NF-kappaB cascade; transcription cofactor activity; zinc ion binding IPR000270; IPR009060; IPR015940; IPR000433; Sequestosome-1 (STONE14) (Ubiquitin-binding protein p62) Sqstm1 A170 STAP Mus musculus (Mouse) TR2573_c0_g1_i1 B1AXD8 AKIR2_MOUSE 1.00E-15 GO:0009790; GO:0045087; GO:0000122; GO:0008284; GO:0010950; GO:0032755; GO:0045944; GO:0032496; GO:0006351; GO:0017053 "embryo development; innate immune response; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation; positive regulation of endopeptidase activity; positive regulation of interleukin-6 production; positive regulation of transcription from RNA polymerase II promoter; response to lipopolysaccharide; transcription, DNA-dependent; transcriptional repressor complex" IPR024132; Akirin-2 Akirin2 Mus musculus (Mouse) TR25731_c1_g1_i1 P59222 SREC2_MOUSE 9.00E-12 GO:0007157; GO:0016021; GO:0005044 heterophilic cell-cell adhesion; integral to membrane; scavenger receptor activity IPR000742; IPR013032; IPR009030; Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) TR25731_c1_g1_i2 Q96GP6 SREC2_HUMAN 5.00E-11 GO:0007157; GO:0016021; GO:0005044 P16333 heterophilic cell-cell adhesion; integral to membrane; scavenger receptor activity IPR000742; IPR013032; IPR002049; IPR009030; Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) TR25731_c2_g1_i1 P41950 YLK2_CAEEL 2.00E-07 GO:0003391; GO:0005509; GO:0007160; GO:0032590; GO:0016021 amphid sensory organ dendrite retrograde extension; calcium ion binding; cell-matrix adhesion; dendrite membrane; integral to membrane IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR023413; IPR009030; IPR003886; EGF-like domain-containing protein D1044.2 D1044.2 Caenorhabditis elegans TR25734_c1_g1_i1 Q6XUX2 DUSTY_RAT 3.00E-26 GO:0005524; GO:0005737; GO:0045111; GO:0005634; GO:0018108; GO:0004674; GO:0004712; GO:0004713 ATP binding; cytoplasm; intermediate filament cytoskeleton; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (Receptor-interacting serine/threonine-protein kinase 5) Dstyk Ripk5 Rattus norvegicus (Rat) TR25736_c3_g1_i1 O88466 ZF106_MOUSE 4.00E-21 GO:0017124; GO:0005829; GO:0008286; GO:0016020; GO:0046872; GO:0005730 SH3 domain binding; cytosol; insulin receptor signaling pathway; membrane; metal ion binding; nucleolus IPR018391; IPR015943; IPR001680; IPR017986; IPR007087; IPR015880; Zinc finger protein 106 (Zfp-106) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant) (Zinc finger protein 474) Znf106 H3a Sh3bp3 Sirm Zfp106 Znf474 Mus musculus (Mouse) TR25742_c0_g2_i1 Q8BN82 S17A5_MOUSE 4.00E-63 GO:0006865; GO:0030054; GO:0016023; GO:0016021; GO:0005765; GO:0005886; GO:0015136; GO:0015739; GO:0015293; GO:0030672 amino acid transport; cell junction; cytoplasmic membrane-bounded vesicle; integral to membrane; lysosomal membrane; plasma membrane; sialic acid transmembrane transporter activity; sialic acid transport; symporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) Slc17a5 Mus musculus (Mouse) TR25742_c1_g1_i1 Q9V7S5 PICO_DROME 4.00E-40 GO:0005315; GO:0016021; GO:0015114; GO:0006817; GO:0006814; GO:0015293 Q9V4M9 inorganic phosphate transmembrane transporter activity; integral to membrane; phosphate ion transmembrane transporter activity; phosphate ion transport; sodium ion transport; symporter activity IPR011701; IPR020846; IPR016196; IPR004745; Putative inorganic phosphate cotransporter Picot CG8098 Drosophila melanogaster (Fruit fly) TR25742_c1_g1_i2 Q03567 YLD2_CAEEL 8.00E-48 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR011701; IPR020846; IPR016196; Uncharacterized transporter C38C10.2 C38C10.2 Caenorhabditis elegans TR25744_c2_g1_i2 Q96PB1 CASD1_HUMAN 7.00E-59 GO:0016021 integral to membrane IPR012419; IPR013763; IPR026057; CAS1 domain-containing protein 1 CASD1 C7orf12 Nbla04196 Homo sapiens (Human) TR25746_c1_g2_i1 Q0D2K2 KLH30_HUMAN 7.00E-17 IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 30 KLHL30 Homo sapiens (Human) TR25749_c0_g1_i1 P57058 HUNK_HUMAN 1.00E-29 GO:0005524; GO:0007275; GO:0004674; GO:0007165 ATP binding; multicellular organismal development; protein serine/threonine kinase activity; signal transduction IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (B19) (Serine/threonine-protein kinase MAK-V) HUNK MAKV Homo sapiens (Human) TR25749_c2_g1_i1 Q68UT7 HUNK_PANTR 9.00E-77 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) HUNK Pan troglodytes (Chimpanzee) TR25751_c0_g2_i1 P34269 TYR1_CAEEL 4.00E-22 GO:0046872; GO:0004497 metal ion binding; monooxygenase activity IPR003582; IPR002227; IPR008922; Putative tyrosinase-like protein tyr-1 tyr-1 C02C2.1/C02C2.2 Caenorhabditis elegans TR25751_c0_g2_i2 H2A0L1 TYRO2_PINMG 2.00E-34 GO:0005576; GO:0046872; GO:0016491 extracellular region; metal ion binding; oxidoreductase activity IPR002227; IPR008922; Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2) Pinctada margaritifera (Black-lipped pearl oyster) TR25754_c0_g1_i1 Q15937 ZNF79_HUMAN 2.00E-88 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 79 (ZNFpT7) ZNF79 Homo sapiens (Human) TR25760_c2_g1_i1 B8JK76 SDCG8_DANRE 5.00E-25 GO:0030054; GO:0005814 cell junction; centriole Serologically defined colon cancer antigen 8 homolog Sdccag8 si:dkey-60B15.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR25764_c3_g1_i1 Q8K0U4 HS12A_MOUSE 2.00E-13 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR25766_c0_g2_i1 Q9D270 ZDH21_MOUSE 2.00E-41 GO:0005794; GO:0001942; GO:0016021; GO:0016409; GO:0018230; GO:0048733; GO:0008270 Golgi apparatus; hair follicle development; integral to membrane; palmitoyltransferase activity; peptidyl-L-cysteine S-palmitoylation; sebaceous gland development; zinc ion binding IPR001594; Probable palmitoyltransferase ZDHHC21 (EC 2.3.1.225) (GABA-A receptor-associated membrane protein 3) (Zinc finger DHHC domain-containing protein 21) (DHHC-21) Zdhhc21 Gramp3 Mus musculus (Mouse) TR25767_c3_g1_i1 A5YM72 CRNS1_HUMAN 1.00E-92 GO:0005524; GO:0016887; GO:0035499; GO:0047730; GO:0046872 ATP binding; ATPase activity; carnosine biosynthetic process; carnosine synthase activity; metal ion binding IPR011761; IPR013816; Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) TR25767_c3_g1_i2 Q12X37 PUR2_METBU 8.00E-06 GO:0006189; GO:0005524; GO:0000287; GO:0030145; GO:0004637; GO:0009113 'de novo' IMP biosynthetic process; ATP binding; magnesium ion binding; manganese ion binding; phosphoribosylamine-glycine ligase activity; purine nucleobase biosynthetic process IPR011761; IPR013815; IPR013816; IPR016185; IPR020561; IPR000115; IPR020560; IPR020559; IPR020562; IPR011054; Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase) purD Mbur_1056 Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) TR25768_c2_g1_i1 Q9YHV4 FSTA_DANRE 3.00E-50 GO:0048263; GO:0005576; GO:0030901; GO:0009994; GO:0043049 determination of dorsal identity; extracellular region; midbrain development; oocyte differentiation; otic placode formation IPR003645; IPR015369; IPR002350; IPR017878; Follistatin-A (FS) (Activin-binding protein) (Follistatin-1) (zFst1) fsta fst fst1 si:dkey-111k10.2 si:dkeyp-88a5.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR25772_c1_g1_i1 Q9Z0J7 GDF15_MOUSE 1.00E-23 GO:0005615 extracellular space IPR001839; IPR015615; Growth/differentiation factor 15 (GDF-15) Gdf15 Sbf Mus musculus (Mouse) TR25776_c0_g1_i1 Q9D5S7 LRGUK_MOUSE 7.00E-51 GO:0005524; GO:0016301 ATP binding; kinase activity IPR008145; IPR008144; IPR001611; IPR027417; Leucine-rich repeat and guanylate kinase domain-containing protein Lrguk Mus musculus (Mouse) TR25776_c0_g1_i2 Q9D5S7 LRGUK_MOUSE 3.00E-167 GO:0005524; GO:0016301 ATP binding; kinase activity IPR008145; IPR008144; IPR001611; IPR027417; Leucine-rich repeat and guanylate kinase domain-containing protein Lrguk Mus musculus (Mouse) TR25780_c0_g1_i1 Q9W4Y2 PDFR_DROME 2.00E-18 GO:0004948; GO:0042332; GO:0005887; GO:0045475; GO:0043005; GO:0043025; GO:0008188; GO:0010579; GO:0042749 calcitonin receptor activity; gravitaxis; integral to plasma membrane; locomotor rhythm; neuron projection; neuronal cell body; neuropeptide receptor activity; positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway; regulation of circadian sleep/wake cycle IPR017981; IPR001879; IPR000832; IPR017983; PDF receptor (Pigment-dispersing factor receptor) (Protein groom-of-PDF) Pdfr gop Han CG13758 Drosophila melanogaster (Fruit fly) TR25782_c1_g1_i1 Q4VC17 ATS18_MOUSE 5.00E-09 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAM-TS 18) (ADAM-TS18) (ADAMTS-18) (EC 3.4.24.-) Adamts18 Mus musculus (Mouse) TR25782_c1_g1_i2 Q9H324 ATS10_HUMAN 3.00E-13 GO:0004222; GO:0001527; GO:0006508; GO:0008270 metalloendopeptidase activity; microfibril; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAM-TS 10) (ADAM-TS10) (ADAMTS-10) (EC 3.4.24.-) ADAMTS10 Homo sapiens (Human) TR25783_c4_g1_i2 B1AWJ5 TMM8B_MOUSE 3.00E-08 GO:0009986; GO:0007160; GO:0005783; GO:0016021; GO:0005739; GO:0005634; GO:0005886; GO:0040008 cell surface; cell-matrix adhesion; endoplasmic reticulum; integral to membrane; mitochondrion; nucleus; plasma membrane; regulation of growth IPR021910; IPR000742; IPR013032; Transmembrane protein 8B (Protein NGX6) Tmem8b Mus musculus (Mouse) TR25784_c0_g2_i1 Q9JID1 PDCD4_RAT 1.00E-109 GO:0003723; GO:0006915; GO:0007569; GO:0005829; GO:0043508; GO:0045892; GO:0005634 "RNA binding; apoptotic process; cell aging; cytosol; negative regulation of JUN kinase activity; negative regulation of transcription, DNA-dependent; nucleus" IPR016024; IPR003891; IPR016021; Programmed cell death protein 4 (Death up-regulated gene protein) Pdcd4 Dug Rattus norvegicus (Rat) TR25786_c0_g1_i1 O93470 MMP21_XENLA 1.00E-100 GO:0005509; GO:0031012; GO:0005576; GO:0004222; GO:0006508; GO:0008270 calcium ion binding; extracellular matrix; extracellular region; metalloendopeptidase activity; proteolysis; zinc ion binding IPR000585; IPR018487; IPR024079; IPR001818; IPR021190; IPR016293; IPR006026; IPR002477; Matrix metalloproteinase-21 (MMP-21) (xMMP) (EC 3.4.24.-) mmp21 mmp Xenopus laevis (African clawed frog) TR25787_c0_g1_i1 Q7PCJ8 SAT2_BOVIN 1.00E-57 GO:0005737; GO:0004145; GO:0009447 cytoplasm; diamine N-acetyltransferase activity; putrescine catabolic process IPR016181; IPR000182; Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1. Diamine acetyltransferase 2 (EC 2.3.1.57) (Polyamine N-acetyltransferase 2) (Spermidine/spermine N(1)-acetyltransferase 2) SAT2 SSAT2 Bos taurus (Bovine) TR25788_c0_g1_i1 Q6PCG7 I2BLB_XENLA 1.00E-139 GO:0046872; GO:0005634 metal ion binding; nucleus IPR022750; Interferon regulatory factor 2-binding protein-like B (Enhanced at puberty protein 1 homolog B) irf2bpl-b eap1-b Xenopus laevis (African clawed frog) TR25789_c0_g1_i1 P19823 ITIH2_HUMAN 5.00E-23 GO:0004866; GO:0005576; GO:0030212; GO:0004867 endopeptidase inhibitor activity; extracellular region; hyaluronan metabolic process; serine-type endopeptidase inhibitor activity IPR010600; IPR013694; IPR002035; Inter-alpha-trypsin inhibitor heavy chain H2 (ITI heavy chain H2) (ITI-HC2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP) ITIH2 IGHEP2 Homo sapiens (Human) TR25793_c0_g1_i1 Q869Z0 Y5025_DICDI 1.00E-09 GO:0045454; GO:0005788; GO:0006662; GO:0003756; GO:0015035; GO:0006457 cell redox homeostasis; endoplasmic reticulum lumen; glycerol ether metabolic process; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; protein folding IPR005788; IPR005746; IPR012336; IPR017937; IPR013766; Putative protein disulfide-isomerase DDB_G0275025 (EC 5.3.4.1) DDB_G0275025 Dictyostelium discoideum (Slime mold) TR25793_c2_g1_i1 Q54EN4 PDI2_DICDI 4.00E-08 GO:0045454; GO:0005788; GO:0006662; GO:0045335; GO:0003756; GO:0015035; GO:0009617; GO:0019953 cell redox homeostasis; endoplasmic reticulum lumen; glycerol ether metabolic process; phagocytic vesicle; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; response to bacterium; sexual reproduction IPR005788; IPR005792; IPR005746; IPR012336; IPR017937; IPR013766; Protein disulfide-isomerase 2 (PDI2) (EC 5.3.4.1) pdi2 DDB_G0291434 Dictyostelium discoideum (Slime mold) TR25793_c5_g1_i1 Q17770 PDI2_CAEEL 2.00E-06 GO:0045454; GO:0005783; GO:0005788; GO:0006662; GO:0055114; GO:0018401; GO:0080058; GO:0003756; GO:0015035; GO:0003810 cell redox homeostasis; endoplasmic reticulum; endoplasmic reticulum lumen; glycerol ether metabolic process; oxidation-reduction process; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; protein deglutathionylation; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; protein-glutamine gamma-glutamyltransferase activity IPR005788; IPR005792; IPR005746; IPR012336; IPR017937; IPR013766; Protein disulfide-isomerase 2 (EC 5.3.4.1) (PDI 1) (Prolyl 4-hydroxylase subunit beta-2) pdi-2 C07A12.4 Caenorhabditis elegans TR25793_c5_g2_i1 Q67UF5 PDI23_ORYSJ 6.00E-09 GO:0045454; GO:0005576; GO:0006662; GO:0003756; GO:0015035; GO:0006457 cell redox homeostasis; extracellular region; glycerol ether metabolic process; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; protein folding IPR005788; IPR005746; IPR012336; IPR017937; IPR013766; Protein disulfide isomerase-like 2-3 (OsPDIL2-3) (EC 5.3.4.1) (Protein disulfide isomerase-like 5-1) (OsPDIL5-1) PDIL2-3 PDIL5-1 Os09g0451500 LOC_Os09g27830 OJ1163_C07.26 P0488D02.3 Oryza sativa subsp. japonica (Rice) TR25793_c6_g1_i1 Q5R5L3 DJC10_PONAB 2.00E-33 GO:0030433; GO:0045454; GO:0005788; GO:0006662; GO:0016671; GO:0015035; GO:0034975 "ER-associated protein catabolic process; cell redox homeostasis; endoplasmic reticulum lumen; glycerol ether metabolic process; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; protein disulfide oxidoreductase activity; protein folding in endoplasmic reticulum" IPR001623; IPR021170; IPR005746; IPR012336; IPR017937; IPR013766; DnaJ homolog subfamily C member 10 (EC 1.8.4.-) DNAJC10 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR25793_c6_g1_i2 Q96EY1 DNJA3_HUMAN 5.00E-19 GO:0005524; GO:0033077; GO:0006919; GO:0006924; GO:0007569; GO:0030054; GO:0005829; GO:0009790; GO:0019897; GO:0005133; GO:0046872; GO:0006264; GO:0005759; GO:0042645; GO:0043124; GO:0032088; GO:0043066; GO:0008285; GO:0043154; GO:0060336; GO:0006469; GO:0000122; GO:0031594; GO:0007528; GO:0005634; GO:0042102; GO:0043065; GO:0031398; GO:0045211; GO:0006457; GO:0050821; GO:0009408; GO:0034341; GO:0071340; GO:0007264; GO:0005083 Q86X55; O60341; P08581; Q96LA8; P51692; P42232 ATP binding; T cell differentiation in thymus; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation-induced cell death of T cells; cell aging; cell junction; cytosol; embryo development; extrinsic to plasma membrane; interferon-gamma receptor binding; metal ion binding; mitochondrial DNA replication; mitochondrial matrix; mitochondrial nucleoid; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of apoptotic process; negative regulation of cell proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of interferon-gamma-mediated signaling pathway; negative regulation of protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; neuromuscular junction; neuromuscular junction development; nucleus; positive regulation of T cell proliferation; positive regulation of apoptotic process; positive regulation of protein ubiquitination; postsynaptic membrane; protein folding; protein stabilization; response to heat; response to interferon-gamma; skeletal muscle acetylcholine-gated channel clustering; small GTPase mediated signal transduction; small GTPase regulator activity IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; "DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)" DNAJA3 HCA57 TID1 Homo sapiens (Human) TR25793_c6_g1_i3 Q5R5L3 DJC10_PONAB 4.00E-33 GO:0030433; GO:0045454; GO:0005788; GO:0006662; GO:0016671; GO:0015035; GO:0034975 "ER-associated protein catabolic process; cell redox homeostasis; endoplasmic reticulum lumen; glycerol ether metabolic process; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; protein disulfide oxidoreductase activity; protein folding in endoplasmic reticulum" IPR001623; IPR021170; IPR005746; IPR012336; IPR017937; IPR013766; DnaJ homolog subfamily C member 10 (EC 1.8.4.-) DNAJC10 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR25794_c1_g2_i1 P47809 MP2K4_MOUSE 1.00E-171 GO:0005524; GO:0007257; GO:0006915; GO:0071260; GO:0005829; GO:0005634; GO:0018108; GO:0004674; GO:0004713 ATP binding; activation of JUN kinase activity; apoptotic process; cellular response to mechanical stimulus; cytosol; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) Map2k4 Jnkk1 Mek4 Mkk4 Prkmk4 Sek1 Serk1 Skk1 Mus musculus (Mouse) TR25797_c2_g2_i1 Q8R507 FKTN_MOUSE 3.00E-73 GO:0005794; GO:0000139; GO:0005801; GO:0005783; GO:0016021; GO:0046329; GO:0008285; GO:0001764; GO:0005634; GO:0060049; GO:0016740 Golgi apparatus; Golgi membrane; cis-Golgi network; endoplasmic reticulum; integral to membrane; negative regulation of JNK cascade; negative regulation of cell proliferation; neuron migration; nucleus; regulation of protein glycosylation; transferase activity IPR009644; IPR007074; Fukutin (EC 2.-.-.-) Fktn Fcmd Mus musculus (Mouse) TR25798_c0_g3_i1 P55043 RAD_RAT 4.00E-24 GO:0005525; GO:0003924; GO:0030308; GO:0005886; GO:0007264 GTP binding; GTPase activity; negative regulation of cell growth; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR001806; IPR017358; IPR020849; GTP-binding protein RAD (RAD1) (Ras associated with diabetes) Rrad Rad Rattus norvegicus (Rat) TR25803_c1_g1_i1 Q8N5C8 TAB3_HUMAN 2.00E-06 GO:0038095; GO:0007249; GO:0007254; GO:0002755; GO:0035666; GO:0000187; GO:0005829; GO:0010008; GO:0045087; GO:0070423; GO:0005886; GO:0051092; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124; GO:0008270 Q14457; O43318; Q62073 Fc-epsilon receptor signaling pathway; I-kappaB kinase/NF-kappaB cascade; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; activation of MAPK activity; cytosol; endosome membrane; innate immune response; nucleotide-binding oligomerization domain containing signaling pathway; plasma membrane; positive regulation of NF-kappaB transcription factor activity; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor TLR1:TLR2 signaling pathway; toll-like receptor TLR6:TLR2 signaling pathway; zinc ion binding IPR003892; IPR001876; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) TAB3 MAP3K7IP3 Homo sapiens (Human) TR25804_c1_g1_i2 P86854 PLCL_MYTGA 1.00E-07 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR25805_c0_g1_i1 Q9QX05 TLR4_RAT 5.00E-08 GO:0002755; GO:0009986; GO:0071260; GO:0005737; GO:0050829; GO:0042742; GO:0032497; GO:0016064; GO:0006954; GO:0045087; GO:0005887; GO:0006691; GO:0001530; GO:0001875; GO:0046696; GO:0002282; GO:0052033; GO:0043388; GO:0051092; GO:0043065; GO:0050729; GO:0050731; GO:0050707; GO:0051930; GO:0014823; GO:0045471; GO:0070542; GO:0001666; GO:0032868; GO:0006979; GO:0032570; GO:0009636; GO:0003009; GO:0034142; GO:0002224; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; cell surface; cellular response to mechanical stimulus; cytoplasm; defense response to Gram-negative bacterium; defense response to bacterium; detection of lipopolysaccharide; immunoglobulin mediated immune response; inflammatory response; innate immune response; integral to plasma membrane; leukotriene metabolic process; lipopolysaccharide binding; lipopolysaccharide receptor activity; lipopolysaccharide receptor complex; microglial cell activation involved in immune response; pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response; positive regulation of DNA binding; positive regulation of NF-kappaB transcription factor activity; positive regulation of apoptotic process; positive regulation of inflammatory response; positive regulation of peptidyl-tyrosine phosphorylation; regulation of cytokine secretion; regulation of sensory perception of pain; response to activity; response to ethanol; response to fatty acid; response to hypoxia; response to insulin stimulus; response to oxidative stress; response to progesterone stimulus; response to toxic substance; skeletal muscle contraction; toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR000157; IPR027168; IPR017241; Toll-like receptor 4 (Toll4) (CD antigen CD284) Tlr4 Rattus norvegicus (Rat) TR25806_c2_g1_i1 O97772 CCKAR_RABIT 5.00E-09 GO:0004951; GO:0038188; GO:0016021; GO:0005886 cholecystokinin receptor activity; cholecystokinin signaling pathway; integral to membrane; plasma membrane IPR009126; IPR000596; IPR015276; IPR000276; IPR017452; Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR Oryctolagus cuniculus (Rabbit) TR25806_c3_g1_i1 Q64121 PRLHR_RAT 3.00E-10 GO:0004930; GO:0007631; GO:0016021; GO:0004983; GO:0017046; GO:0005886 G-protein coupled receptor activity; feeding behavior; integral to membrane; neuropeptide Y receptor activity; peptide hormone binding; plasma membrane IPR000276; IPR017452; IPR001402; Prolactin-releasing peptide receptor (PrRP receptor) (PrRPR) (G-protein coupled receptor 10) (UHR-1) Prlhr Gpr10 Rattus norvegicus (Rat) TR25806_c4_g1_i1 Q9Y5X5 NPFF2_HUMAN 6.00E-10 GO:0004930; GO:0015629; GO:0009582; GO:0005887; GO:0008188; GO:0007218; GO:0043408; GO:0045761; GO:2000479 G-protein coupled receptor activity; actin cytoskeleton; detection of abiotic stimulus; integral to plasma membrane; neuropeptide receptor activity; neuropeptide signaling pathway; regulation of MAPK cascade; regulation of adenylate cyclase activity; regulation of cAMP-dependent protein kinase activity IPR000276; IPR017452; IPR005395; IPR005397; Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) NPFFR2 GPR74 NPFF2 NPGPR Homo sapiens (Human) TR25807_c0_g1_i1 A7Y2X0 SC6A5_XENLA 2.00E-34 GO:0016021; GO:0005328 integral to membrane; neurotransmitter:sodium symporter activity IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (xGlyT2) (Solute carrier family 6 member 5) slc6a5 glyt2 Xenopus laevis (African clawed frog) TR25807_c0_g1_i2 Q96N87 S6A18_HUMAN 1.00E-10 GO:0006865; GO:0005887; GO:0005328; GO:0005886; GO:0055085 amino acid transport; integral to plasma membrane; neurotransmitter:sodium symporter activity; plasma membrane; transmembrane transport IPR000175; IPR002438; Sodium-dependent neutral amino acid transporter B(0)AT3 (Sodium- and chloride-dependent transporter XTRP2) (Solute carrier family 6 member 18) (System B(0) neutral amino acid transporter AT3) SLC6A18 XTRP2 Homo sapiens (Human) TR25807_c0_g1_i3 A7Y2W8 SC6A9_XENLA 1.00E-29 GO:0005887; GO:0005328; GO:0005283 integral to plasma membrane; neurotransmitter:sodium symporter activity; sodium:amino acid symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9) slc6a9 glyt1 Xenopus laevis (African clawed frog) TR25808_c2_g1_i1 Q708W2 FXJ1A_XENLA 1.00E-57 GO:0003677; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "DNA binding; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; Forkhead box protein J1-A (FoxJ1-A) (FoxJ1a) (xFoxJ1) (Forkhead protein 5) (xFKH5) foxj1-a Xenopus laevis (African clawed frog) TR25810_c0_g2_i1 Q7LKZ7 BPH1_SCHPO 3.00E-06 GO:0005829; GO:0016020; GO:0046872; GO:0035091; GO:0043234; GO:0009268 cytosol; membrane; metal ion binding; phosphatidylinositol binding; protein complex; response to pH IPR000409; IPR008985; IPR013320; IPR023362; IPR015943; IPR001680; IPR017986; IPR000306; IPR011011; IPR013083; Beige protein homolog 1 lvs1 SPBC28E12.06c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR25810_c2_g1_i1 Q6VNB8 WDFY3_MOUSE 4.00E-32 GO:0005545; GO:0005776; GO:0003831; GO:0005737; GO:0019898; GO:0046872; GO:0005635 "1-phosphatidylinositol binding; autophagic vacuole; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; cytoplasm; extrinsic to membrane; metal ion binding; nuclear envelope" IPR011989; IPR016024; IPR000409; IPR008985; IPR023362; IPR015943; IPR001680; IPR019775; IPR017986; IPR000306; IPR017455; IPR011011; IPR013083; "WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1)" Wdfy3 Mus musculus (Mouse) TR25810_c3_g1_i1 Q6ZS81 WDFY4_HUMAN 3.00E-06 GO:0016021 integral to membrane IPR011989; IPR016024; IPR000409; IPR023362; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat- and FYVE domain-containing protein 4 WDFY4 C10orf64 KIAA1607 Homo sapiens (Human) TR25810_c3_g1_i3 Q5PQT2 MTMR3_RAT 1.00E-11 GO:0005737; GO:0016020; GO:0046872; GO:0046856; GO:0004438; GO:0004722; GO:0004725 cytoplasm; membrane; metal ion binding; phosphatidylinositol dephosphorylation; phosphatidylinositol-3-phosphatase activity; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity IPR010569; IPR017906; IPR016130; IPR000306; IPR017455; IPR011011; IPR013083; Myotubularin-related protein 3 (EC 3.1.3.48) Mtmr3 Rattus norvegicus (Rat) TR25810_c3_g1_i4 Q9H1K0 RBNS5_HUMAN 1.00E-06 GO:0007596; GO:0031901; GO:0016197; GO:0010008; GO:0005886; GO:0015031; GO:0008270 blood coagulation; early endosome membrane; endosomal transport; endosome membrane; plasma membrane; protein transport; zinc ion binding IPR021565; IPR007087; IPR015880; IPR000306; IPR017455; IPR011011; IPR013083; Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) ZFYVE20 Homo sapiens (Human) TR25810_c3_g4_i1 Q8W1K8 MUT11_CHLRE 8.00E-06 GO:0005634 nucleus IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Protein Mut11 (Mut11p) Mut11 Chlamydomonas reinhardtii (Chlamydomonas smithii) TR25810_c3_g4_i2 Q8IZQ1 WDFY3_HUMAN 0 GO:0005545; GO:0003831; GO:0005737; GO:0019898; GO:0046872; GO:0005635 Q9H1Y0; P42858 "1-phosphatidylinositol binding; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; cytoplasm; extrinsic to membrane; metal ion binding; nuclear envelope" IPR011989; IPR016024; IPR000409; IPR008985; IPR023362; IPR015943; IPR001680; IPR019775; IPR017986; IPR000306; IPR017455; IPR011011; IPR013083; WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy) WDFY3 KIAA0993 Homo sapiens (Human) TR25812_c0_g1_i1 Q58237 Y827_METJA 3.00E-19 GO:0016021 integral to membrane IPR001107; IPR018080; IPR001972; Uncharacterized protein MJ0827 MJ0827 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR25812_c0_g1_i2 Q19958 STO2_CAEEL 3.00E-51 GO:0016021 integral to membrane IPR001107; IPR018080; IPR001972; Stomatin-2 sto-2 F32A6.5 Caenorhabditis elegans TR25814_c4_g1_i1 Q498S8 FZD8_RAT 8.00E-48 GO:0004930; GO:0005794; GO:0030165; GO:0033077; GO:0042813; GO:0017147; GO:0007409; GO:0007420; GO:0060070; GO:0042995; GO:0005737; GO:0009790; GO:0008406; GO:0016021; GO:0005886; GO:0001944 G-protein coupled receptor activity; Golgi apparatus; PDZ domain binding; T cell differentiation in thymus; Wnt-activated receptor activity; Wnt-protein binding; axonogenesis; brain development; canonical Wnt receptor signaling pathway; cell projection; cytoplasm; embryo development; gonad development; integral to membrane; plasma membrane; vasculature development IPR000539; IPR015526; IPR020067; IPR026547; IPR017981; Frizzled-8 (Fz-8) Fzd8 Rattus norvegicus (Rat) TR25819_c0_g1_i1 O18598 GST1_BLAGE 5.00E-17 GO:0004364 glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase (EC 2.5.1.18) (GST class-sigma) (Major allergen Bla g 5) (allergen Bla g 5) Blattella germanica (German cockroach) (Blatta germanica) TR25823_c1_g1_i1 Q27J81 INF2_HUMAN 5.00E-24 GO:0030036; GO:0005783; GO:0005634; GO:0048471; GO:0090140 actin cytoskeleton organization; endoplasmic reticulum; nucleus; perinuclear region of cytoplasm; regulation of mitochondrial fission IPR016024; IPR015425; IPR010472; IPR010473; IPR014768; IPR027649; IPR003124; Inverted formin-2 (HBEBP2-binding protein C) INF2 C14orf151 C14orf173 Homo sapiens (Human) TR25825_c0_g1_i1 Q26474 LACH_SCHAM 2.00E-06 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Lachesin LAC Schistocerca americana (American grasshopper) TR25825_c1_g1_i1 Q98892 OBCAM_CHICK 2.00E-06 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Opioid-binding protein/cell adhesion molecule homolog (Neurite inhibitor GP55-A) (OBCAM protein gamma isoform) OPCML Gallus gallus (Chicken) TR25827_c2_g1_i1 Q9BXC9 BBS2_HUMAN 1.00E-52 GO:0034464; GO:0043001; GO:0030534; GO:0014824; GO:0048854; GO:0021987; GO:0060170; GO:0005737; GO:0045444; GO:0021766; GO:0032402; GO:0005932; GO:0031514; GO:0038108; GO:0010629; GO:0040015; GO:0045494; GO:0040018; GO:0033365; GO:0060296; GO:0007288; GO:0021756; GO:0042311; GO:0007601 P05062; Q8NFJ9; Q8IWZ6; Q3SYG4; Q9NPJ1 BBSome; Golgi to plasma membrane protein transport; adult behavior; artery smooth muscle contraction; brain morphogenesis; cerebral cortex development; cilium membrane; cytoplasm; fat cell differentiation; hippocampus development; melanosome transport; microtubule basal body; motile cilium; negative regulation of appetite by leptin-mediated signaling pathway; negative regulation of gene expression; negative regulation of multicellular organism growth; photoreceptor cell maintenance; positive regulation of multicellular organism growth; protein localization to organelle; regulation of cilium beat frequency involved in ciliary motility; sperm axoneme assembly; striatum development; vasodilation; visual perception IPR016616; IPR015943; IPR017986; Bardet-Biedl syndrome 2 protein BBS2 Homo sapiens (Human) TR25828_c1_g1_i1 Q76CA2 ACTP2_CYMEC 8.00E-29 GO:0019835; GO:0044179; GO:0016021; GO:0006811; GO:0044218 cytolysis; hemolysis in other organism; integral to membrane; ion transport; other organism cell membrane IPR015926; Echotoxin-2 (Echt 2) Cymatium echo (Giant triton) (Monoplex echo) TR25829_c0_g1_i1 Q0P6H9 TMM62_HUMAN 1.00E-68 GO:0016021 integral to membrane Transmembrane protein 62 TMEM62 Homo sapiens (Human) TR25830_c0_g2_i1 P26652 TIMP3_CHICK 9.00E-06 GO:0046872; GO:0008191; GO:0005578 metal ion binding; metalloendopeptidase inhibitor activity; proteinaceous extracellular matrix IPR001134; IPR001820; IPR008993; IPR027465; IPR015612; Metalloproteinase inhibitor 3 (21 kDa protein of extracellular matrix) (Tissue inhibitor of metalloproteinases 3) (TIMP-3) TIMP3 IMP-3 Gallus gallus (Chicken) TR25831_c3_g1_i1 Q08DX0 SNX29_BOVIN 7.00E-07 GO:0007154; GO:0035091 cell communication; phosphatidylinositol binding IPR001683; IPR004012; Sorting nexin-29 SNX29 Bos taurus (Bovine) TR25831_c3_g1_i2 Q4G017 NISCH_RAT 1.00E-59 GO:0008227; GO:0006915; GO:0005829; GO:0005769; GO:0006006; GO:0016020; GO:0048243; GO:0035091; GO:0005886; GO:0055037; GO:0008217; GO:0032228 "G-protein coupled amine receptor activity; apoptotic process; cytosol; early endosome; glucose metabolic process; membrane; norepinephrine secretion; phosphatidylinositol binding; plasma membrane; recycling endosome; regulation of blood pressure; regulation of synaptic transmission, GABAergic" IPR001611; IPR001683; Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline-1 receptor) (I1R) Nisch Rattus norvegicus (Rat) TR25834_c2_g1_i1 P51658 DHB2_MOUSE 3.00E-37 GO:0004303; GO:0001701; GO:0016021; GO:0001890; GO:0032526; GO:0006694; GO:0047035 estradiol 17-beta-dehydrogenase activity; in utero embryonic development; integral to membrane; placenta development; response to retinoic acid; steroid biosynthetic process; testosterone dehydrogenase (NAD+) activity IPR002198; IPR002347; IPR016040; IPR020904; Estradiol 17-beta-dehydrogenase 2 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 2) (17-beta-HSD 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) Hsd17b2 Edh17b2 Mus musculus (Mouse) TR25835_c0_g1_i1 Q2TV78 MSTP9_HUMAN 5.00E-26 GO:0005576; GO:0006508; GO:0004252 extracellular region; proteolysis; serine-type endopeptidase activity IPR024174; IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR001254; IPR001314; IPR009003; Putative macrophage stimulating 1-like protein (Brain rescue factor 1) (BRF-1) (Hepatocyte growth factor-like protein homolog) MST1L D1F15S1A MST1P9 MSTP9 Homo sapiens (Human) TR25835_c0_g1_i2 Q01177 PLMN_RAT 7.00E-43 GO:0006915; GO:0007596; GO:0004175; GO:0022617; GO:0005615; GO:0031232; GO:0042730; GO:0043231; GO:0060716; GO:0071674; GO:0046716; GO:0045445; GO:0010812; GO:0051918; GO:0005886; GO:0051919; GO:0051603; GO:0004252; GO:0042246; GO:0048771; GO:0060707 apoptotic process; blood coagulation; endopeptidase activity; extracellular matrix disassembly; extracellular space; extrinsic to external side of plasma membrane; fibrinolysis; intracellular membrane-bounded organelle; labyrinthine layer blood vessel development; mononuclear cell migration; muscle cell cellular homeostasis; myoblast differentiation; negative regulation of cell-substrate adhesion; negative regulation of fibrinolysis; plasma membrane; positive regulation of fibrinolysis; proteolysis involved in cellular protein catabolic process; serine-type endopeptidase activity; tissue regeneration; tissue remodeling; trophoblast giant cell differentiation IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]" Plg Rattus norvegicus (Rat) TR25839_c0_g1_i1 P58659 F176C_MOUSE 5.00E-17 GO:0030246; GO:0016021; GO:0005886 carbohydrate binding; integral to membrane; plasma membrane IPR000922; Protein eva-1 homolog C (Protein FAM176C) Eva1c Fam176c Mus musculus (Mouse) TR25839_c1_g1_i1 P86179 CSL3_ONCKE 1.00E-06 GO:0030246 carbohydrate binding IPR000922; L-rhamnose-binding lectin CSL3 Oncorhynchus keta (Chum salmon) (Salmo keta) TR25840_c4_g1_i1 A8JAM0 CC135_CHLRE 5.00E-06 GO:0030154; GO:0001539; GO:0031514; GO:0007283 cell differentiation; ciliary or bacterial-type flagellar motility; motile cilium; spermatogenesis IPR015915; IPR001611; Coiled-coil domain-containing protein lobo homolog (Flagellar-associated protein 50) (Fragment) FAP50 CHLREDRAFT_177591 Chlamydomonas reinhardtii (Chlamydomonas smithii) TR25841_c2_g1_i1 Q9BV94 EDEM2_HUMAN 5.00E-45 GO:0005509; GO:0005788; GO:0005789; GO:0005576; GO:0043687; GO:0018279; GO:0006457; GO:0006986 calcium ion binding; endoplasmic reticulum lumen; endoplasmic reticulum membrane; extracellular region; post-translational protein modification; protein N-linked glycosylation via asparagine; protein folding; response to unfolded protein IPR001382; ER degradation-enhancing alpha-mannosidase-like protein 2 EDEM2 C20orf31 C20orf49 UNQ573/PRO1135 Homo sapiens (Human) TR25841_c2_g2_i1 O02773 MA1A1_PIG 2.00E-06 GO:0005509; GO:0005789; GO:0016021; GO:0004571; GO:0006486 "calcium ion binding; endoplasmic reticulum membrane; integral to membrane; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; protein glycosylation" IPR001382; Protein modification; protein glycosylation. "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Man9-mannosidase) (Mannosidase alpha class 1A member 1) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA)" MAN1A1 MAN1A Sus scrofa (Pig) TR25850_c0_g1_i1 Q91WN1 DNJC9_MOUSE 4.00E-69 GO:0035176 social behavior IPR001623; IPR018253; DnaJ homolog subfamily C member 9 Dnajc9 Mus musculus (Mouse) TR25851_c0_g1_i1 O75489 NDUS3_HUMAN 5.00E-70 GO:0008137; GO:0009055; GO:0006120; GO:0005747; GO:0030308; GO:2001243; GO:0072593; GO:0044281 O75306 "NADH dehydrogenase (ubiquinone) activity; electron carrier activity; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I; negative regulation of cell growth; negative regulation of intrinsic apoptotic signaling pathway; reactive oxygen species metabolic process; small molecule metabolic process" IPR010218; IPR001268; IPR020396; "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-30kD) (CI-30kD) (NADH-ubiquinone oxidoreductase 30 kDa subunit)" NDUFS3 Homo sapiens (Human) TR25858_c4_g1_i1 Q13591 SEM5A_HUMAN 3.00E-73 GO:0007411; GO:0008046; GO:0007155; GO:0007267; GO:0016021; GO:0001569; GO:0005886 axon guidance; axon guidance receptor activity; cell adhesion; cell-cell signaling; integral to membrane; patterning of blood vessels; plasma membrane IPR016201; IPR002165; IPR001627; IPR027231; IPR000884; IPR015943; Semaphorin-5A (Semaphorin-F) (Sema F) SEMA5A SEMAF Homo sapiens (Human) TR25858_c4_g2_i1 Q62217 SEM5A_MOUSE 3.00E-70 GO:0008046; GO:0016021; GO:0001569 axon guidance receptor activity; integral to membrane; patterning of blood vessels IPR016201; IPR002165; IPR001627; IPR027231; IPR000884; IPR015943; Semaphorin-5A (Semaphorin-F) (Sema F) Sema5a Semaf SemF Mus musculus (Mouse) TR25860_c1_g1_i2 Q96JN8 NEUL4_HUMAN 4.00E-26 GO:0005814 O43303 centriole IPR008985; IPR006573; Neuralized-like protein 4 NEURL4 KIAA1787 Homo sapiens (Human) TR25862_c0_g1_i1 Q95029 CATL_DROME 2.00E-31 GO:0008234; GO:0007586; GO:0045169; GO:0005764; GO:0006508; GO:0035071 cysteine-type peptidase activity; digestion; fusome; lysosome; proteolysis; salivary gland cell autophagic cell death IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L (EC 3.4.22.15) (Cysteine proteinase 1) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] Cp1 fs(2)50Ca CG6692 Drosophila melanogaster (Fruit fly) TR25862_c0_g1_i2 Q94503 CYSP6_DICDI 8.00E-15 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cysteine proteinase 6 (EC 3.4.22.-) cprF CP6 DDB_G0279185 Dictyostelium discoideum (Slime mold) TR25864_c0_g1_i1 Q90773 CEPU1_CHICK 6.00E-06 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Protein CEPU-1 Gallus gallus (Chicken) TR25872_c0_g1_i1 Q9PKP3 PKN1_CHLMU 2.00E-21 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR016187; IPR005532; IPR011009; IPR000719; Serine/threonine-protein kinase pkn1 (EC 2.7.11.1) pkn1 TC_0422 Chlamydia muridarum (strain MoPn / Nigg) TR25872_c0_g1_i2 Q8R0F3 SUMF1_MOUSE 5.00E-98 GO:0005783; GO:0005788; GO:0046872; GO:0016491 endoplasmic reticulum; endoplasmic reticulum lumen; metal ion binding; oxidoreductase activity IPR016187; IPR005532; Protein modification; sulfatase oxidation. Sulfatase-modifying factor 1 (EC 1.8.99.-) (C-alpha-formylglycine-generating enzyme 1) Sumf1 Fge Mus musculus (Mouse) TR25876_c0_g1_i1 Q9D581 EFC10_MOUSE 3.00E-24 GO:0005509 calcium ion binding IPR003117; IPR011992; IPR002048; EF-hand calcium-binding domain-containing protein 10 Efcab10 Mus musculus (Mouse) TR25877_c0_g1_i1 Q4R5Y0 CK001_MACFA 3.00E-27 GO:0005634 nucleus IPR009524; UPF0686 protein C11orf1 homolog QtsA-19889 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR25878_c3_g1_i1 E1C1L6 ENTP5_CHICK 8.00E-64 GO:0051084; GO:0046034; GO:0016049; GO:0008283; GO:0005783; GO:0005789; GO:0006096; GO:0004382; GO:0016021; GO:0006487; GO:0014066; GO:0045134 'de novo' posttranslational protein folding; ATP metabolic process; cell growth; cell proliferation; endoplasmic reticulum; endoplasmic reticulum membrane; glycolysis; guanosine-diphosphatase activity; integral to membrane; protein N-linked glycosylation; regulation of phosphatidylinositol 3-kinase cascade; uridine-diphosphatase activity IPR000407; Protein modification; protein glycosylation. Ectonucleoside triphosphate diphosphohydrolase 5 (NTPDase 5) (EC 3.6.1.6) (Guanosine-diphosphatase ENTPD5) (GDPase ENTPD5) (EC 3.6.1.42) (Uridine-diphosphatase ENTPD5) (UDPase ENTPD5) ENTPD5 Gallus gallus (Chicken) TR25879_c0_g1_i1 E9QJ05 PT117_DANRE 1.00E-11 GO:0005739 mitochondrion "Protein PET117 homolog, mitochondrial" pet117 si:dkeyp-20e4.6 Danio rerio (Zebrafish) (Brachydanio rerio) TR25880_c2_g1_i1 Q2LZ62 POMT1_DROPS 2.00E-96 GO:0004169; GO:0005783; GO:0005789; GO:0016021; GO:0030259; GO:0007517; GO:0006493; GO:0007385 "dolichyl-phosphate-mannose-protein mannosyltransferase activity; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; lipid glycosylation; muscle organ development; protein O-linked glycosylation; specification of segmental identity, abdomen" IPR027005; IPR003342; IPR016093; Protein modification; protein glycosylation. Protein O-mannosyltransferase 1 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 1) (Protein rotated abdomen) rt GA19350 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR25883_c0_g1_i1 Q400C9 AMZ1_RAT 8.00E-12 GO:0046872; GO:0008237; GO:0006508 metal ion binding; metallopeptidase activity; proteolysis Archaemetzincin-1 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 1) Amz1 Rattus norvegicus (Rat) TR25883_c0_g1_i2 Q400C7 AMZ2_RAT 1.00E-25 GO:0008237; GO:0006508; GO:0008270 metallopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR012962; Archaemetzincin-2 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 2) Amz2 Rattus norvegicus (Rat) TR25883_c0_g3_i1 Q400C8 AMZ2_MOUSE 6.00E-16 GO:0008237; GO:0006508; GO:0008270 metallopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR012962; Archaemetzincin-2 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 2) Amz2 Mus musculus (Mouse) TR25888_c3_g1_i1 Q05084 ICA69_HUMAN 6.00E-40 GO:0000139; GO:0030054; GO:0005829; GO:0006836; GO:0005634; GO:0030667; GO:0030672; GO:0030658 Golgi membrane; cell junction; cytosol; neurotransmitter transport; nucleus; secretory granule membrane; synaptic vesicle membrane; transport vesicle membrane IPR027267; IPR010504; IPR024114; IPR006723; Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69) ICA1 Homo sapiens (Human) TR25889_c4_g2_i1 Q9P1Z9 CI174_HUMAN 2.00E-17 GO:0016021 integral to membrane IPR028089; IPR027914; IPR026701; Coiled-coil domain-containing protein 180 CCDC180 C9orf174 KIAA1529 Homo sapiens (Human) TR25892_c0_g1_i1 Q24400 MLP2_DROME 3.00E-37 GO:0030018; GO:0007517; GO:0060537; GO:0005634; GO:0090175; GO:0045214; GO:0008307; GO:0008270 Z disc; muscle organ development; muscle tissue development; nucleus; regulation of establishment of planar polarity; sarcomere organization; structural constituent of muscle; zinc ion binding IPR001781; Muscle LIM protein Mlp84B Mlp84B LIM3 CG10699 Drosophila melanogaster (Fruit fly) TR25894_c0_g1_i3 Q96FX8 PERP_HUMAN 2.00E-08 GO:0005794; GO:0097202; GO:0097186; GO:0006915; GO:0030054; GO:0030057; GO:0002934; GO:0034113; GO:0005887; GO:0005739; GO:0005634; GO:0005886; GO:0045862 Golgi apparatus; activation of cysteine-type endopeptidase activity; amelogenesis; apoptotic process; cell junction; desmosome; desmosome organization; heterotypic cell-cell adhesion; integral to plasma membrane; mitochondrion; nucleus; plasma membrane; positive regulation of proteolysis IPR015664; IPR004031; p53 apoptosis effector related to PMP-22 (Keratinocyte-associated protein 1) (KCP-1) (P53-induced protein PIGPC1) (Transmembrane protein THW) PERP KCP1 KRTCAP1 PIGPC1 THW Homo sapiens (Human) TR25896_c1_g1_i1 P46595 UBC4_SCHPO 7.00E-18 GO:0005524; GO:0008054; GO:0005829; GO:0000070; GO:0005634; GO:0071630; GO:0000209; GO:0016485; GO:0004842 ATP binding; cyclin catabolic process; cytosol; mitotic sister chromatid segregation; nucleus; nucleus-associated proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein processing; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 4 (EC 6.3.2.19) (Ubiquitin carrier protein 4) (Ubiquitin-protein ligase 4) ubc4 SPBC119.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR25896_c1_g2_i1 P15732 UBC5_YEAST 5.00E-16 GO:0005524; GO:0034605; GO:0000502; GO:0000209; GO:0004842 ATP binding; cellular response to heat; proteasome complex; protein polyubiquitination; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2-16 kDa (EC 6.3.2.19) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) UBC5 YDR059C D4234 YD9609.13C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR25896_c1_g2_i2 O74196 UBC1_COLGL 1.00E-16 GO:0005524; GO:0004842 ATP binding; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2-16 kDa (EC 6.3.2.19) (Colletotrichum hard-surface-induced protein 1) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) UBC1 CHIP1 Colletotrichum gloeosporioides (Anthracnose fungus) (Glomerella cingulata) TR25897_c0_g1_i1 Q3I5F7 ACOT6_HUMAN 5.00E-13 GO:0004091; GO:0005829 carboxylesterase activity; cytosol IPR014940; Putative acyl-coenzyme A thioesterase 6 (Putative acyl-CoA thioesterase 6) (EC 3.1.2.-) ACOT6 C14orf42 Homo sapiens (Human) TR25897_c1_g1_i1 Q8BGG9 ACNT2_MOUSE 8.00E-53 GO:0016410; GO:0006637; GO:0006631; GO:0005777; GO:0016790 N-acyltransferase activity; acyl-CoA metabolic process; fatty acid metabolic process; peroxisome; thiolester hydrolase activity IPR016662; IPR014940; IPR006862; Acyl-coenzyme A amino acid N-acyltransferase 2 (EC 2.3.1.-) Acnat2 Mus musculus (Mouse) TR25898_c0_g1_i1 Q9Z0V2 KCND2_MOUSE 6.00E-07 GO:0005250; GO:0009986; GO:0030425; GO:0016020; GO:0046872; GO:0051260; GO:0001508; GO:0008076 Q99PW8 A-type (transient outward) potassium channel activity; cell surface; dendrite; membrane; metal ion binding; protein homooligomerization; regulation of action potential; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003975; IPR004055; IPR024587; IPR021645; IPR003131; IPR028325; Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2) Kcnd2 Kiaa1044 MNCb-7013 Mus musculus (Mouse) TR25898_c0_g2_i1 Q8BJK1 KCTD7_MOUSE 1.00E-26 GO:0005829; GO:0005886; GO:0051260 cytosol; plasma membrane; protein homooligomerization IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein KCTD7 Kctd7 Mus musculus (Mouse) TR259_c0_g1_i1 Q8C8H8 KY_MOUSE 1.00E-07 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) TR25901_c0_g1_i1 O86034 BDHA_RHIME 3.00E-64 GO:0003858 3-hydroxybutyrate dehydrogenase activity IPR011294; IPR002198; IPR002347; IPR016040; IPR020904; D-beta-hydroxybutyrate dehydrogenase (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (3-HBDH) bdhA RB1136 SMb21010 Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) TR25901_c0_g1_i2 Q9GME3 DHB8_CALJA 5.00E-08 GO:0003857; GO:0008209; GO:0004303; GO:0006703; GO:0006633; GO:0005740; GO:0005759; GO:0005886; GO:0047035 3-hydroxyacyl-CoA dehydrogenase activity; androgen metabolic process; estradiol 17-beta-dehydrogenase activity; estrogen biosynthetic process; fatty acid biosynthetic process; mitochondrial envelope; mitochondrial matrix; plasma membrane; testosterone dehydrogenase (NAD+) activity IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. Steroid biosynthesis; estrogen biosynthesis. Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239) (Fragment) HSD17B8 Callithrix jacchus (White-tufted-ear marmoset) TR25905_c0_g1_i1 O73888 HPGDS_CHICK 2.00E-21 GO:0005509; GO:0005737; GO:0004364; GO:0000287; GO:0005634; GO:0001516; GO:0006693; GO:0004667 calcium ion binding; cytoplasm; glutathione transferase activity; magnesium ion binding; nucleus; prostaglandin biosynthetic process; prostaglandin metabolic process; prostaglandin-D synthase activity IPR010987; IPR004045; IPR004046; IPR012336; Hematopoietic prostaglandin D synthase (H-PGDS) (EC 5.3.99.2) (GST class-sigma) (Glutathione S-transferase) (EC 2.5.1.18) (Glutathione-dependent PGD synthase) (Glutathione-requiring prostaglandin D synthase) (Prostaglandin-H2 D-isomerase) HPGDS GSTS PGDS PTGDS2 Gallus gallus (Chicken) TR25906_c0_g1_i1 Q9H0J9 PAR12_HUMAN 2.00E-09 GO:0003950; GO:0046872; GO:0005634 NAD+ ADP-ribosyltransferase activity; metal ion binding; nucleus IPR012317; IPR004170; IPR000571; Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) TR25906_c2_g1_i2 Q460N5 PAR14_HUMAN 1.00E-12 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR25906_c3_g1_i1 Q9WYX8 Y508_THEMA 5.00E-12 GO:0005524; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0009378 ATP binding; DNA binding; DNA recombination; DNA repair; DNA replication; four-way junction helicase activity IPR003593; IPR008824; IPR008921; IPR002589; IPR021886; IPR027417; Uncharacterized protein TM_0508 TM_0508 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR25910_c0_g1_i1 Q86UW6 N4BP2_HUMAN 2.00E-37 GO:0005524; GO:0046404; GO:0005829; GO:0004519 ATP binding; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; cytosol; endonuclease activity IPR003892; IPR013899; IPR027417; IPR002625; IPR009060; NEDD4-binding protein 2 (N4BP2) (EC 3.-.-.-) (BCL-3-binding protein) N4BP2 B3BP KIAA1413 Homo sapiens (Human) TR25914_c1_g1_i1 Q00547 HMMR_MOUSE 7.00E-06 GO:0009986; GO:0005737; GO:0005540 cell surface; cytoplasm; hyaluronic acid binding IPR026203; Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168) Hmmr Ihabp Rhamm Mus musculus (Mouse) TR25917_c0_g1_i1 Q6P819 RCD1_XENTR 0 GO:0030014; GO:0000932; GO:0031047; GO:0033147; GO:0005634; GO:2000327; GO:0006355; GO:0006417; GO:0006351 "CCR4-NOT complex; cytoplasmic mRNA processing body; gene silencing by RNA; negative regulation of intracellular estrogen receptor signaling pathway; nucleus; positive regulation of ligand-dependent nuclear receptor transcription coactivator activity; regulation of transcription, DNA-dependent; regulation of translation; transcription, DNA-dependent" IPR011989; IPR016024; IPR007216; Cell differentiation protein RCD1 homolog (Rcd-1) rqcd1 rcd1 TNeu111l17.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR2592_c0_g1_i1 O95239 KIF4A_HUMAN 4.00E-28 GO:0005524; GO:0003677; GO:0008089; GO:0019886; GO:0007411; GO:0007596; GO:0005694; GO:0005829; GO:0005871; GO:0003777; GO:0030496; GO:0016363; GO:0005634; GO:0006996; GO:0005876 ATP binding; DNA binding; anterograde axon cargo transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; axon guidance; blood coagulation; chromosome; cytosol; kinesin complex; microtubule motor activity; midbody; nuclear matrix; nucleus; organelle organization; spindle microtubule IPR027640; IPR019821; IPR001752; IPR027417; Chromosome-associated kinesin KIF4A (Chromokinesin-A) KIF4A KIF4 Homo sapiens (Human) TR25921_c1_g1_i1 Q6TGJ4 ATG9_CRYGA 5.00E-19 GO:0000139; GO:0006914; GO:0030659; GO:0005789; GO:0016021; GO:0034045; GO:0015031 Golgi membrane; autophagy; cytoplasmic vesicle membrane; endoplasmic reticulum membrane; integral to membrane; pre-autophagosomal structure membrane; protein transport IPR007241; Autophagy-related protein 9 ATG9 APG9 Cryptococcus gattii (Filobasidiella gattii) (Cryptococcus bacillisporus) TR25921_c3_g1_i2 P0CM40 ATG9_CRYNJ 1.00E-14 GO:0000139; GO:0006914; GO:0030659; GO:0005789; GO:0016021; GO:0034045; GO:0015031 Golgi membrane; autophagy; cytoplasmic vesicle membrane; endoplasmic reticulum membrane; integral to membrane; pre-autophagosomal structure membrane; protein transport IPR007241; Autophagy-related protein 9 ATG9 CND05590 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR25921_c4_g1_i1 Q5RCS0 ATG9A_PONAB 6.00E-74 GO:0005794; GO:0000421; GO:0006914; GO:0031410; GO:0016021; GO:0031902; GO:0015031 Golgi apparatus; autophagic vacuole membrane; autophagy; cytoplasmic vesicle; integral to membrane; late endosome membrane; protein transport IPR007241; Autophagy-related protein 9A (APG9-like 1) ATG9A APG9L1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR25923_c0_g1_i1 Q5RB79 RPP14_PONAB 8.00E-29 GO:0005634; GO:0004526; GO:0008033 nucleus; ribonuclease P activity; tRNA processing IPR002759; Ribonuclease P protein subunit p14 (EC 3.1.26.5) RPP14 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR25925_c0_g1_i1 F1NPG5 CENPT_CHICK 9.00E-18 GO:0003677; GO:0051301; GO:0007059; GO:0000777; GO:0051382; GO:0007067; GO:0005634 E1BSW7; P0DJH6 DNA binding; cell division; chromosome segregation; condensed chromosome kinetochore; kinetochore assembly; mitosis; nucleus IPR028255; IPR009072; Centromere protein T (CENP-T) CENPT Gallus gallus (Chicken) TR25929_c4_g1_i1 Q8JHV9 BIR7A_XENLA 6.00E-17 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR25929_c4_g1_i2 Q13490 BIRC2_HUMAN 3.00E-09 GO:0035631; GO:0038061; GO:0035666; GO:0007166; GO:0006921; GO:0005829; GO:0045087; GO:0009898; GO:0070266; GO:0043066; GO:0005634; GO:0001890; GO:0043123; GO:0043161; GO:0000209; GO:0039535; GO:0051726; GO:0045595; GO:0042127; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0006355; GO:0034138; GO:0034142; GO:0003713; GO:0006351; GO:0004842; GO:0008270 P55210; Q9NR28; P63000; Q13546; O43353; Q9Y572; P57078; Q9NP84; Q12933 "CD40 receptor complex; NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; cell surface receptor signaling pathway; cellular component disassembly involved in execution phase of apoptosis; cytosol; innate immune response; internal side of plasma membrane; necroptosis; negative regulation of apoptotic process; nucleus; placenta development; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of RIG-I signaling pathway; regulation of cell cycle; regulation of cell differentiation; regulation of cell proliferation; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; regulation of transcription, DNA-dependent; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (IAP-2) (hIAP-2) (hIAP2) (RING finger protein 48) (TNFR2-TRAF-signaling complex protein 2) BIRC2 API1 IAP2 MIHB RNF48 Homo sapiens (Human) TR25936_c1_g1_i1 Q60352 Y044_METJA 3.00E-20 GO:0005524; GO:0004349; GO:0006561 ATP binding; glutamate 5-kinase activity; proline biosynthetic process IPR001048; IPR024192; IPR001057; Isopentenyl phosphate kinase (IPK) (EC 2.7.4.26) MJ0044 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR25938_c1_g1_i2 Q6U841 S4A10_HUMAN 1.00E-34 GO:0016323; GO:0015701; GO:0006821; GO:0005452; GO:0016021; GO:0005886; GO:0006885; GO:0006814; GO:0015293; GO:0055085 basolateral plasma membrane; bicarbonate transport; chloride transport; inorganic anion exchanger activity; integral to membrane; plasma membrane; regulation of pH; sodium ion transport; symporter activity; transmembrane transport IPR013769; IPR011531; IPR003020; IPR003024; IPR016152; Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10) SLC4A10 NCBE Homo sapiens (Human) TR25940_c2_g1_i1 Q2XWK0 SVOP_XENLA 5.00E-23 GO:0030054; GO:0016021; GO:0030672; GO:0022857 cell junction; integral to membrane; synaptic vesicle membrane; transmembrane transporter activity IPR011701; IPR020846; IPR016196; IPR005828; Synaptic vesicle 2-related protein (SV2-related protein) svop Xenopus laevis (African clawed frog) TR25946_c0_g1_i1 Q9CR92 CCD96_MOUSE 4.00E-54 IPR025254; Coiled-coil domain-containing protein 96 Ccdc96 Mus musculus (Mouse) TR25952_c0_g1_i1 Q9NBX4 RTXE_DROME 2.00E-28 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR25955_c2_g1_i1 Q9DEX7 FADS2_DANRE 8.00E-58 GO:0005789; GO:0020037; GO:0016021; GO:0005506; GO:0016717; GO:0006636 "endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; unsaturated fatty acid biosynthetic process" IPR001199; IPR012171; IPR005804; Lipid metabolism; polyunsaturated fatty acid biosynthesis. Fatty acid desaturase 2 (EC 1.14.19.-) (Delta(5)/Delta(6) fatty acid desaturase) (D5D/D6D fatty acid desaturase) (Delta-5/Delta-6 fatty acid desaturase) fads2 fadsd6 Danio rerio (Zebrafish) (Brachydanio rerio) TR25955_c3_g1_i1 Q0VAX3 FS2P1_MOUSE 3.00E-48 GO:0005789; GO:0020037; GO:0016021; GO:0005506; GO:0016717; GO:0006636 "endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; unsaturated fatty acid biosynthetic process" IPR001199; IPR012171; IPR005804; Lipid metabolism; polyunsaturated fatty acid biosynthesis. Fatty acid desaturase 2-like protein FADS2P1 Fads2p1 Mus musculus (Mouse) TR25956_c1_g1_i1 Q5VV63 ATRN1_HUMAN 1.00E-32 GO:0007186; GO:0030246; GO:0016021; GO:0007275; GO:0004872 G-protein coupled receptor signaling pathway; carbohydrate binding; integral to membrane; multicellular organismal development; receptor activity IPR001304; IPR016186; IPR016187; IPR000859; IPR000742; IPR013032; IPR013111; IPR002049; IPR015915; IPR016201; IPR002165; Attractin-like protein 1 ATRNL1 KIAA0534 Homo sapiens (Human) TR25957_c3_g1_i1 Q9UF83 YM012_HUMAN 6.00E-10 Uncharacterized protein DKFZp434B061 Homo sapiens (Human) TR25957_c3_g2_i2 O43825 B3GT2_HUMAN 2.00E-42 GO:0000139; GO:0008499; GO:0016021; GO:0009312; GO:0006486 "Golgi membrane; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; integral to membrane; oligosaccharide biosynthetic process; protein glycosylation" IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 2 (Beta-1,3-GalTase 2) (Beta3Gal-T2) (Beta3GalT2) (EC 2.4.1.-) (UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2)" B3GALT2 Homo sapiens (Human) TR25958_c2_g1_i1 Q8CIY2 DUOX1_RAT 2.00E-08 GO:0016174; GO:0016324; GO:0005509; GO:0042335; GO:0019221; GO:0020037; GO:0042446; GO:0042744; GO:0016021; GO:0004601; GO:0051591; GO:0006590 NAD(P)H oxidase activity; apical plasma membrane; calcium ion binding; cuticle development; cytokine-mediated signaling pathway; heme binding; hormone biosynthetic process; hydrogen peroxide catabolic process; integral to membrane; peroxidase activity; response to cAMP; thyroid hormone generation IPR011992; IPR018247; IPR002048; IPR013112; IPR017927; IPR013130; IPR013121; IPR010255; IPR002007; IPR019791; IPR017938; Hormone biosynthesis; thyroid hormone biosynthesis. Dual oxidase 1 (EC 1.11.1.-) (EC 1.6.3.1) Duox1 Rattus norvegicus (Rat) TR25958_c4_g1_i1 H2A0M7 PLSP_PINMG 6.00E-44 GO:0005576; GO:0020037; GO:0004601; GO:0006979 extracellular region; heme binding; peroxidase activity; response to oxidative stress IPR010255; IPR002007; IPR019791; Peroxidase-like protein Pinctada margaritifera (Black-lipped pearl oyster) TR25961_c2_g1_i1 Q92108 ANXA1_CHICK 4.00E-06 GO:0016323; GO:0005509; GO:0005544; GO:0005929; GO:0005737; GO:0005634; GO:0019834 basolateral plasma membrane; calcium ion binding; calcium-dependent phospholipid binding; cilium; cytoplasm; nucleus; phospholipase A2 inhibitor activity IPR001464; IPR018502; IPR018252; IPR002388; Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) (Fragment) ANXA1 ANX1 Gallus gallus (Chicken) TR25961_c3_g1_i1 P27216 ANX13_HUMAN 2.00E-30 GO:0005509; GO:0005544; GO:0030154; GO:0005886 calcium ion binding; calcium-dependent phospholipid binding; cell differentiation; plasma membrane IPR001464; IPR018502; IPR018252; IPR009166; Annexin A13 (Annexin XIII) (Annexin-13) (Intestine-specific annexin) (ISA) ANXA13 ANX13 Homo sapiens (Human) TR25961_c4_g1_i1 P17153 ANXA5_CHICK 5.00E-11 GO:0005509; GO:0005544; GO:0050819 Q8AYS8 calcium ion binding; calcium-dependent phospholipid binding; negative regulation of coagulation IPR001464; IPR018502; IPR018252; IPR015473; IPR002392; Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CBP-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) ANXA5 ANX5 Gallus gallus (Chicken) TR25962_c2_g1_i1 Q3UHD1 BAI1_MOUSE 3.00E-14 GO:0004930; GO:0016021; GO:0016525; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; negative regulation of angiogenesis; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR008077; IPR001879; IPR000832; IPR000203; IPR000884; Brain-specific angiogenesis inhibitor 1 Bai1 Mus musculus (Mouse) TR25962_c2_g1_i2 Q8CGM1 BAI2_MOUSE 9.00E-10 GO:0004930; GO:0016021; GO:0016525; GO:0007218; GO:0007422; GO:0005886 Q06547 G-protein coupled receptor activity; integral to membrane; negative regulation of angiogenesis; neuropeptide signaling pathway; peripheral nervous system development; plasma membrane IPR022624; IPR017981; IPR008077; IPR001879; IPR000832; IPR000203; IPR000884; Brain-specific angiogenesis inhibitor 2 Bai2 Mus musculus (Mouse) TR25965_c0_g3_i1 O73791 TIE2_DANRE 3.00E-06 GO:0005524; GO:0005737; GO:0005856; GO:0005925; GO:0007507; GO:0005887; GO:0018108; GO:0004714; GO:0007169 ATP binding; cytoplasm; cytoskeleton; focal adhesion; heart development; integral to plasma membrane; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000742; IPR013032; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR011009; IPR000719; IPR017441; IPR001245; IPR018941; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-2 (EC 2.7.10.1) (Tyrosine kinase with Ig and EGF homology domains-2) tie2 tie-2 Danio rerio (Zebrafish) (Brachydanio rerio) TR25969_c1_g1_i1 P0AAR9 YBAV_SHIFL 3.00E-13 GO:0003677; GO:0006281 DNA binding; DNA repair IPR004509; IPR003583; IPR010994; Uncharacterized protein YbaV ybaV SF0387 S0393 Shigella flexneri TR25969_c2_g1_i1 Q93794 SEL10_CAEEL 1.00E-138 GO:0030424; GO:0005737; GO:0046660; GO:0045746 P17221; P49594; P34691; P14585; P31695; G5ECU1 axon; cytoplasm; female sex differentiation; negative regulation of Notch signaling pathway IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein sel-10 (Egg laying defective protein 41) (Suppressor/enhancer of lin-12 protein 10) sel-10 egl-41 F55B12.3 Caenorhabditis elegans TR25969_c2_g1_i2 Q969H0 FBXW7_HUMAN 0 GO:0005794; GO:0007219; GO:0019005; GO:0031146; GO:0034644; GO:0005783; GO:0055088; GO:0030324; GO:0019048; GO:0032876; GO:0045746; GO:2000639; GO:2000346; GO:0010868; GO:0005730; GO:0005654; GO:0070374; GO:0045741; GO:2000060; GO:0043234; GO:0050821; GO:0016567; GO:0010883; GO:0032880; GO:0006974; GO:0003700; GO:0007062; GO:0001944; GO:0001570 Q16204; P24941; P01106; P63208; Q9UBI4 Golgi apparatus; Notch signaling pathway; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cellular response to UV; endoplasmic reticulum; lipid homeostasis; lung development; modulation by virus of host morphology or physiology; negative regulation of DNA endoreduplication; negative regulation of Notch signaling pathway; negative regulation of SREBP signaling pathway; negative regulation of hepatocyte proliferation; negative regulation of triglyceride biosynthetic process; nucleolus; nucleoplasm; positive regulation of ERK1 and ERK2 cascade; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein complex; protein stabilization; protein ubiquitination; regulation of lipid storage; regulation of protein localization; response to DNA damage stimulus; sequence-specific DNA binding transcription factor activity; sister chromatid cohesion; vasculature development; vasculogenesis IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4) FBXW7 FBW7 FBX30 SEL10 Homo sapiens (Human) TR25971_c2_g1_i1 O15440 MRP5_HUMAN 4.00E-103 GO:0005524; GO:0006200; GO:0042626; GO:0005975; GO:0030213; GO:0005887; GO:0008514 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; carbohydrate metabolic process; hyaluronan biosynthetic process; integral to plasma membrane; organic anion transmembrane transporter activity" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) (pABC11) ABCC5 MRP5 Homo sapiens (Human) TR25972_c2_g1_i1 Q76L83 ASXL2_HUMAN 5.00E-24 GO:0003677; GO:0046872; GO:0005634; GO:0042975; GO:0045600; GO:0035360; GO:0045944; GO:0006351 "DNA binding; metal ion binding; nucleus; peroxisome proliferator activated receptor binding; positive regulation of fat cell differentiation; positive regulation of peroxisome proliferator activated receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR026905; IPR024811; IPR028020; IPR024817; IPR007759; Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) ASXL2 ASXH2 KIAA1685 Homo sapiens (Human) TR25976_c1_g1_i1 O75592 MYCB2_HUMAN 3.00E-84 GO:0030424; GO:0021785; GO:0021952; GO:0015630; GO:0005634; GO:0051493; GO:0032880; GO:0006355; GO:0006351; GO:0004842; GO:0008270 Q99IB8 "axon; branchiomotor neuron axon guidance; central nervous system projection neuron axonogenesis; microtubule cytoskeleton; nucleus; regulation of cytoskeleton organization; regulation of protein localization; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR004939; IPR017868; IPR008979; IPR027047; IPR013783; IPR014756; IPR012983; IPR009091; IPR000408; IPR003646; IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc) MYCBP2 KIAA0916 PAM Homo sapiens (Human) TR25976_c2_g1_i1 Q17551 RPM1_CAEEL 7.00E-22 GO:0030424; GO:0010171; GO:0040011; GO:0043409; GO:0031594; GO:0005634; GO:0018991; GO:0036062; GO:0031647; GO:0050807; GO:0006355; GO:0006351; GO:0004842; GO:0008270 "axon; body morphogenesis; locomotion; negative regulation of MAPK cascade; neuromuscular junction; nucleus; oviposition; presynaptic periactive zone; regulation of protein stability; regulation of synapse organization; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR004939; IPR008979; IPR027047; IPR012983; IPR009091; IPR000408; IPR000315; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase rpm-1 (EC 6.3.2.-) (Pam/highwire/rpm-1 protein) (Regulator of presynaptic morphology protein 1) (Synapse defective protein 3) rpm-1 syd-3 C01B7.6 Caenorhabditis elegans TR25976_c4_g1_i1 O75592 MYCB2_HUMAN 3.00E-15 GO:0030424; GO:0021785; GO:0021952; GO:0015630; GO:0005634; GO:0051493; GO:0032880; GO:0006355; GO:0006351; GO:0004842; GO:0008270 Q99IB8 "axon; branchiomotor neuron axon guidance; central nervous system projection neuron axonogenesis; microtubule cytoskeleton; nucleus; regulation of cytoskeleton organization; regulation of protein localization; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR004939; IPR017868; IPR008979; IPR027047; IPR013783; IPR014756; IPR012983; IPR009091; IPR000408; IPR003646; IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc) MYCBP2 KIAA0916 PAM Homo sapiens (Human) TR25979_c0_g1_i1 Q5R544 C1R_PONAB 4.00E-06 GO:0005509; GO:0006958; GO:0005576; GO:0045087; GO:0006508; GO:0004252 "calcium ion binding; complement activation, classical pathway; extracellular region; innate immune response; proteolysis; serine-type endopeptidase activity" IPR000859; IPR001881; IPR013032; IPR000152; IPR018097; IPR024175; IPR001254; IPR018114; IPR001314; IPR000436; IPR009003; Complement C1r subcomponent (EC 3.4.21.41) (Complement component 1 subcomponent r) [Cleaved into: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain] C1R Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR25979_c1_g1_i1 O57460 TLL1_DANRE 2.00E-24 GO:0001568; GO:0005509; GO:0048264; GO:0035124; GO:0035162; GO:0001885; GO:0005576; GO:0001707; GO:0004222; GO:0008237; GO:0030513; GO:0036342; GO:0006508; GO:0008270 blood vessel development; calcium ion binding; determination of ventral identity; embryonic caudal fin morphogenesis; embryonic hemopoiesis; endothelial cell development; extracellular region; mesoderm formation; metalloendopeptidase activity; metallopeptidase activity; positive regulation of BMP signaling pathway; post-anal tail morphogenesis; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Dorsal-ventral patterning tolloid-like protein 1 (EC 3.4.24.-) (Mini fin protein) tll1 mfn tld tolloid Danio rerio (Zebrafish) (Brachydanio rerio) TR25979_c1_g1_i4 P98070 BMP1_XENLA 8.00E-24 GO:0005794; GO:0005509; GO:0051216; GO:0030154; GO:0005615; GO:0004222; GO:0001503; GO:0005578; GO:0006508; GO:0008270 B5MFE9 Golgi apparatus; calcium ion binding; cartilage development; cell differentiation; extracellular space; metalloendopeptidase activity; ossification; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.-) bmp1 Xenopus laevis (African clawed frog) TR25980_c0_g1_i1 Q9CRB9 CHCH3_MOUSE 3.00E-18 GO:0001227; GO:0007007; GO:0008053; GO:0005743; GO:0005634; GO:0019902; GO:0032947 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; inner mitochondrial membrane organization; mitochondrial fusion; mitochondrial inner membrane; nucleus; phosphatase binding; protein complex scaffold IPR007964; "Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial" Chchd3 Mus musculus (Mouse) TR25982_c3_g1_i1 Q8IUK5 PLDX1_HUMAN 1.00E-08 GO:0001525; GO:0005737; GO:0005576; GO:0005615; GO:0016021; GO:0005622; GO:0005886; GO:0004872; GO:0005923 angiogenesis; cytoplasm; extracellular region; extracellular space; integral to membrane; intracellular; plasma membrane; receptor activity; tight junction IPR016201; IPR002165; Plexin domain-containing protein 1 (Tumor endothelial marker 3) (Tumor endothelial marker 7) PLXDC1 TEM3 TEM7 Homo sapiens (Human) TR25984_c0_g1_i1 F6ZQ54 TRI13_XENTR 8.00E-08 GO:0005789; GO:0016021; GO:0016874; GO:0016567; GO:0008270 endoplasmic reticulum membrane; integral to membrane; ligase activity; protein ubiquitination; zinc ion binding IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif containing 13 trim13 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR25987_c1_g1_i1 Q53G44 IF44L_HUMAN 3.00E-27 GO:0005737; GO:0051607; GO:0006955 cytoplasm; defense response to virus; immune response IPR024644; IPR027417; Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) TR25993_c2_g1_i1 Q8LGE9 CSTR1_ARATH 5.00E-17 GO:0000139; GO:0016021; GO:0005338; GO:0015780; GO:0015136; GO:0015739; GO:0005351 Golgi membrane; integral to membrane; nucleotide-sugar transmembrane transporter activity; nucleotide-sugar transport; sialic acid transmembrane transporter activity; sialic acid transport; sugar:hydrogen symporter activity IPR007271; IPR021189; IPR004689; CMP-sialic acid transporter 1 (CMP-SA-Tr 1) (CMP-Sia-Tr 1) At5g41760 K16L22.3 Arabidopsis thaliana (Mouse-ear cress) TR25994_c1_g1_i1 Q8K1P8 MOT8_RAT 4.00E-09 GO:0016021; GO:0005886; GO:0015293; GO:0015349 integral to membrane; plasma membrane; symporter activity; thyroid hormone transmembrane transporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 8 (MCT 8) (Solute carrier family 16 member 2) Slc16a2 Mct8 Rattus norvegicus (Rat) TR25994_c1_g2_i1 O15403 MOT7_HUMAN 5.00E-13 GO:0005887; GO:0008028; GO:0015293 integral to plasma membrane; monocarboxylic acid transmembrane transporter activity; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 7 (MCT 7) (Monocarboxylate transporter 6) (MCT 6) (Solute carrier family 16 member 6) SLC16A6 MCT6 MCT7 Homo sapiens (Human) TR25994_c2_g1_i1 Q6GM59 MOT12_XENLA 3.00E-13 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 Xenopus laevis (African clawed frog) TR25995_c1_g1_i1 Q7RTX9 MOT14_HUMAN 1.00E-12 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR25996_c0_g1_i1 Q6GLC9 FMR1_XENTR 2.00E-23 GO:0003723; GO:0005737; GO:0051028; GO:0045947; GO:0005634 RNA binding; cytoplasm; mRNA transport; negative regulation of translational initiation; nucleus IPR008395; IPR022034; IPR004087; IPR004088; Fragile X mental retardation protein 1 homolog (Protein FMR-1) (XtFmrp) (FMRP) fmr1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR25996_c1_g1_i1 P51114 FXR1_HUMAN 5.00E-15 GO:0002151; GO:0003723; GO:0006915; GO:0030154; GO:0043034; GO:0005737; GO:0003730; GO:0007517; GO:0017148; GO:0005730; GO:0005844 G-quadruplex RNA binding; RNA binding; apoptotic process; cell differentiation; costamere; cytoplasm; mRNA 3'-UTR binding; muscle organ development; negative regulation of translation; nucleolus; polysome IPR008395; IPR022034; IPR004087; IPR004088; Fragile X mental retardation syndrome-related protein 1 (hFXR1p) FXR1 Homo sapiens (Human) TR25998_c0_g1_i1 P86856 MANL_MYTCA 4.00E-178 GO:0005576 extracellular region IPR001148; IPR023561; Nacrein-like protein (Fragment) Mytilus californianus (California mussel) TR25998_c0_g2_i1 A0ZSF5 MAP2_MIZYE 4.00E-24 GO:0004089; GO:0046872; GO:0005578 carbonate dehydratase activity; metal ion binding; proteinaceous extracellular matrix IPR001148; IPR023561; IPR008160; Nacrein-like protein P2 (EC 4.2.1.1) Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) TR26001_c0_g1_i1 Q99L28 RLP24_MOUSE 3.00E-78 GO:0005730; GO:0042254 nucleolus; ribosome biogenesis IPR023442; IPR023441; IPR000988; IPR024546; IPR011017; Probable ribosome biogenesis protein RLP24 (Ribosomal L24 domain-containing protein 1) (Ribosomal protein L24-like) Rsl24d1 Mus musculus (Mouse) TR26002_c6_g1_i1 P51784 UBP11_HUMAN 3.00E-09 GO:0004197; GO:0005737; GO:0005634; GO:0016579; GO:0004221; GO:0006511; GO:0004843 P35226; Q9HC52; P03129; Q9DLK6; P15659; P35227; Q06587; Q99496; P04608 cysteine-type endopeptidase activity; cytoplasm; nucleus; protein deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR006615; IPR018200; IPR001394; IPR028135; IPR028134; Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.4.19.12) (Deubiquitinating enzyme 11) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11) USP11 UHX1 Homo sapiens (Human) TR26004_c3_g1_i1 Q9HCX4 TRPC7_HUMAN 1.00E-116 GO:0007411; GO:0005262; GO:0016021; GO:0006828; GO:0005635; GO:0005886; GO:0030168 axon guidance; calcium channel activity; integral to membrane; manganese ion transport; nuclear envelope; plasma membrane; platelet activation IPR002110; IPR020683; IPR005821; IPR004729; IPR013555; IPR005463; IPR002153; Short transient receptor potential channel 7 (TrpC7) (Transient receptor protein 7) (TRP-7) (hTRP7) TRPC7 TRP7 Homo sapiens (Human) TR26004_c4_g1_i1 Q9EQG6 KDIS_RAT 4.00E-06 GO:0030165; GO:0016482; GO:0005829; GO:0016021; GO:0005770; GO:0038180; GO:0010976; GO:0043234; GO:0019901; GO:0019887 P46109 PDZ domain binding; cytoplasmic transport; cytosol; integral to membrane; late endosome; nerve growth factor signaling pathway; positive regulation of neuron projection development; protein complex; protein kinase binding; protein kinase regulator activity IPR002110; IPR020683; IPR011646; IPR013761; Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) Kidins220 Arms Rattus norvegicus (Rat) TR26006_c0_g1_i1 Q91WF7 FIG4_MOUSE 2.00E-107 GO:0008219; GO:0010008; GO:0007626; GO:0032288; GO:0031642; GO:0048666; GO:0046488; GO:0042578; GO:0043473; GO:0007033 cell death; endosome membrane; locomotory behavior; myelin assembly; negative regulation of myelination; neuron development; phosphatidylinositol metabolic process; phosphoric ester hydrolase activity; pigmentation; vacuole organization IPR002013; "Polyphosphoinositide phosphatase (EC 3.1.3.-) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3)" Fig4 Kiaa0274 Sac3 Mus musculus (Mouse) TR26007_c6_g2_i1 Q8I7T3 SADA_DICDI 5.00E-07 GO:0015629; GO:0007015; GO:0005938; GO:0000902; GO:0031589; GO:0016021; GO:0000281; GO:0006909; GO:0005886; GO:0034394; GO:0050821 actin cytoskeleton; actin filament organization; cell cortex; cell morphogenesis; cell-substrate adhesion; integral to membrane; mitotic cytokinesis; phagocytosis; plasma membrane; protein localization to cell surface; protein stabilization IPR000742; IPR013032; Substrate-adhesion molecule sadA DDB_G0288511 Dictyostelium discoideum (Slime mold) TR26007_c6_g2_i2 Q00546 TENR_CHICK 5.00E-06 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR013032; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin-R (TN-R) (Restrictin) TNR Gallus gallus (Chicken) TR26009_c2_g2_i1 Q8C779 CX057_MOUSE 2.00E-17 IPR012340; Uncharacterized protein CXorf57 homolog Mus musculus (Mouse) TR26010_c0_g1_i1 Q8BKJ9 SIR7_MOUSE 2.00E-12 GO:0070403; GO:0097372; GO:0003682; GO:0005737; GO:0070932; GO:0046872; GO:0000122; GO:0005731; GO:0007072; GO:0009303 NAD+ binding; NAD-dependent histone deacetylase activity (H3-K18 specific); chromatin binding; cytoplasm; histone H3 deacetylation; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleolus organizer region; positive regulation of transcription on exit from mitosis; rRNA transcription IPR003000; IPR026590; NAD-dependent protein deacetylase sirtuin-7 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7) Sirt7 Sir2l7 Mus musculus (Mouse) TR26010_c0_g1_i2 Q9FE17 SIR1_ARATH 9.00E-16 GO:0070403; GO:0016787; GO:0046872; GO:0005634 NAD+ binding; hydrolase activity; metal ion binding; nucleus IPR003000; IPR026590; NAD-dependent protein deacetylase SRT1 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) SRT1 At5g55760 MDF20.20 Arabidopsis thaliana (Mouse-ear cress) TR26010_c1_g1_i1 B8ARK7 SIR1_ORYSI 5.00E-07 GO:0003677; GO:0070403; GO:0006342; GO:0005677; GO:0005737; GO:0016787; GO:0046872 DNA binding; NAD+ binding; chromatin silencing; chromatin silencing complex; cytoplasm; hydrolase activity; metal ion binding IPR003000; IPR026590; NAD-dependent protein deacetylase SRT1 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) SRT1 OsI_15145 Oryza sativa subsp. indica (Rice) TR26012_c1_g1_i1 P16423 POLR_DROME 3.00E-13 GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0046872; GO:0090305; GO:0006508 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR000477; IPR007087; IPR015880; Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM (Retrovirus-related Pol polyprotein from type II retrotransposable element R2DM) [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR26013_c0_g1_i1 Q28IE5 NIT2_XENTR 8.00E-144 GO:0005737; GO:0006807; GO:0050152 cytoplasm; nitrogen compound metabolic process; omega-amidase activity IPR003010; Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2) nit2 TNeu073c04.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR26014_c1_g1_i1 Q60YT6 NEUFC_CAEBR 6.00E-13 GO:0005576; GO:0020037 extracellular region; heme binding IPR001199; Neuferricin homolog (Cytochrome b5 domain-containing protein 2 homolog) tag-131 CBG18095 Caenorhabditis briggsae TR26014_c1_g1_i3 Q6IUR5 NENF_RAT 8.00E-35 GO:0005615; GO:0020037; GO:0046872; GO:0043410 extracellular space; heme binding; metal ion binding; positive regulation of MAPK cascade IPR001199; Neudesin (Neuron-derived neurotrophic factor) (SCIRP10-related protein) (Spinal cord injury-related protein 10) Nenf Scirp10 Rattus norvegicus (Rat) TR26015_c0_g1_i1 Q91WQ5 TAF5L_MOUSE 9.00E-22 GO:0030914; GO:0043966; GO:0004402; GO:0006355; GO:0003713; GO:0033276; GO:0006351 "STAGA complex; histone H3 acetylation; histone acetyltransferase activity; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription factor TFTC complex; transcription, DNA-dependent" IPR020472; IPR007582; IPR015943; IPR001680; IPR019775; IPR017986; TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65-beta) Taf5l Paf65b Mus musculus (Mouse) TR26015_c1_g1_i1 Q91WQ5 TAF5L_MOUSE 6.00E-18 GO:0030914; GO:0043966; GO:0004402; GO:0006355; GO:0003713; GO:0033276; GO:0006351 "STAGA complex; histone H3 acetylation; histone acetyltransferase activity; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription factor TFTC complex; transcription, DNA-dependent" IPR020472; IPR007582; IPR015943; IPR001680; IPR019775; IPR017986; TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65-beta) Taf5l Paf65b Mus musculus (Mouse) TR26020_c0_g1_i1 P25788 PSA3_HUMAN 1.00E-134 GO:0006977; GO:0000082; GO:0031145; GO:0002479; GO:0006915; GO:0005829; GO:0010467; GO:0016071; GO:0019048; GO:0043066; GO:0051436; GO:0005654; GO:0051437; GO:0005839; GO:0019773; GO:0000209; GO:0006521; GO:0044281; GO:0004298; GO:0016032 Q00987; P29590; P25786; P25789; P60900; O14818 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G1/S transition of mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic process; cytosol; gene expression; mRNA metabolic process; modulation by virus of host morphology or physiology; negative regulation of apoptotic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; proteasome core complex; proteasome core complex, alpha-subunit complex; protein polyubiquitination; regulation of cellular amino acid metabolic process; small molecule metabolic process; threonine-type endopeptidase activity; viral process" IPR000426; IPR023332; IPR001353; Proteasome subunit alpha type-3 (EC 3.4.25.1) (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) PSMA3 HC8 PSC8 Homo sapiens (Human) TR26021_c1_g1_i1 Q69ZU6 THS7A_MOUSE 2.00E-06 GO:0001525; GO:0030154; GO:0005576; GO:0016021; GO:0005886 angiogenesis; cell differentiation; extracellular region; integral to membrane; plasma membrane IPR000884; Thrombospondin type-1 domain-containing protein 7A Thsd7a Gm837 Kiaa0960 Mus musculus (Mouse) TR26021_c1_g1_i2 P98167 SSPO_BOVIN 9.00E-12 GO:0007155; GO:0005615; GO:0010466; GO:0030414 cell adhesion; extracellular space; negative regulation of peptidase activity; peptidase inhibitor activity IPR000421; IPR006207; IPR008979; IPR001545; IPR023415; IPR002172; IPR008037; IPR000884; IPR002919; IPR014853; IPR006552; IPR001007; IPR001846; SCO-spondin SSPO Bos taurus (Bovine) TR26023_c0_g1_i1 P91924 ARF_DUGJA 2.00E-69 GO:0005525; GO:0005794; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor Dugesia japonica (Planarian) TR26024_c3_g1_i1 Q13263 TIF1B_HUMAN 3.00E-07 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR26025_c0_g1_i1 Q5GIS3 GBB_PINFU 3.00E-54 GO:0005737; GO:0004871 cytoplasm; signal transducer activity IPR020472; IPR001632; IPR016346; IPR015943; IPR001680; IPR019775; IPR017986; Guanine nucleotide-binding protein subunit beta (pfGbeta1) (G protein subunit beta-1) Pinctada fucata (Pearl oyster) TR2603_c0_g1_i1 Q8BTM8 FLNA_MOUSE 2.00E-35 GO:0034988; GO:0031523; GO:0048365; GO:0051764; GO:0031532; GO:0051015; GO:0007195; GO:0005938; GO:0030030; GO:0005737; GO:0051220; GO:0005856; GO:0045022; GO:0001837; GO:0045184; GO:0001948; GO:0042177; GO:0043433; GO:0005634; GO:0005886; GO:0043123; GO:0042993; GO:0005080; GO:0034394; GO:0050821; GO:0043113; GO:0004871; GO:0090307; GO:0005802; GO:0008134 Q8CIH5 Fc-gamma receptor I complex binding; Myb complex; Rac GTPase binding; actin crosslink formation; actin cytoskeleton reorganization; actin filament binding; adenylate cyclase-inhibiting dopamine receptor signaling pathway; cell cortex; cell projection organization; cytoplasm; cytoplasmic sequestering of protein; cytoskeleton; early endosome to late endosome transport; epithelial to mesenchymal transition; establishment of protein localization; glycoprotein binding; negative regulation of protein catabolic process; negative regulation of sequence-specific DNA binding transcription factor activity; nucleus; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor import into nucleus; protein kinase C binding; protein localization to cell surface; protein stabilization; receptor clustering; signal transducer activity; spindle assembly involved in mitosis; trans-Golgi network; transcription factor binding IPR001589; IPR001715; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Flna Fln Fln1 Mus musculus (Mouse) TR26030_c0_g1_i2 Q801D8 MPRA_CYNNE 7.00E-19 GO:0030154; GO:0016021; GO:0007275; GO:0048477; GO:0005886; GO:0005496 cell differentiation; integral to membrane; multicellular organismal development; oogenesis; plasma membrane; steroid binding IPR004254; Membrane progestin receptor alpha (mPR alpha) (Membrane progesterone receptor) mpra Cynoscion nebulosus (Spotted seatrout) (Otolithus nebulosus) TR26032_c0_g1_i1 P36410 RAB14_DICDI 3.00E-21 GO:0005525; GO:0000331; GO:0005768; GO:0005764; GO:0016020; GO:0045335; GO:0015031; GO:0007264 GTP binding; contractile vacuole; endosome; lysosome; membrane; phagocytic vesicle; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-14 (Rab4-like GTPase) rab14 rab4 rabD DDB_G0281337 Dictyostelium discoideum (Slime mold) TR26032_c0_g1_i3 Q99KL7 RAB28_MOUSE 4.00E-110 GO:0019003; GO:0005525; GO:0035253; GO:0036064; GO:0005886; GO:0007264 GDP binding; GTP binding; ciliary rootlet; cilium basal body; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; Ras-related protein Rab-28 Rab28 Mus musculus (Mouse) TR26034_c0_g1_i1 Q8K3L6 GIMA5_RAT 2.00E-11 GO:0005525; GO:0030217; GO:0043029; GO:0016021; GO:0005764; GO:0005741; GO:0005739; GO:0043011; GO:0050868; GO:0043066; GO:0032689; GO:0050995; GO:0045019; GO:0032831; GO:0010524; GO:0045588; GO:0002925; GO:0045838; GO:0002729; GO:0045954; GO:0046902; GO:0001659 "GTP binding; T cell differentiation; T cell homeostasis; integral to membrane; lysosome; mitochondrial outer membrane; mitochondrion; myeloid dendritic cell differentiation; negative regulation of T cell activation; negative regulation of apoptotic process; negative regulation of interferon-gamma production; negative regulation of lipid catabolic process; negative regulation of nitric oxide biosynthetic process; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of calcium ion transport into cytosol; positive regulation of gamma-delta T cell differentiation; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of membrane potential; positive regulation of natural killer cell cytokine production; positive regulation of natural killer cell mediated cytotoxicity; regulation of mitochondrial membrane permeability; temperature homeostasis" IPR006703; IPR027417; GTPase IMAP family member 5 (Immunity-associated nucleotide 4 protein) (IAN-4) (Immunity-associated nucleotide 4-like 1 protein) Gimap5 Ian4 Ian4l1 Iddm1 Lyp Rattus norvegicus (Rat) TR26034_c2_g1_i1 Q9NUV9 GIMA4_HUMAN 1.00E-18 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR26035_c0_g1_i1 Q37546 NU1M_LUMTE 5.00E-114 GO:0008137; GO:0016021; GO:0005743; GO:0070469 NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial inner membrane; respiratory chain IPR001694; IPR018086; NADH-ubiquinone oxidoreductase chain 1 (EC 1.6.5.3) (NADH dehydrogenase subunit 1) ND1 Lumbricus terrestris (Common earthworm) TR26036_c0_g1_i1 P42750 UBC6_ARATH 7.00E-12 GO:0005524; GO:0006511; GO:0004842 ATP binding; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 6 (EC 6.3.2.19) (Ubiquitin carrier protein 6) (Ubiquitin-conjugating enzyme E2-21 kDa 3) (Ubiquitin-protein ligase 6) UBC6 At2g46030 T3F17.32 Arabidopsis thaliana (Mouse-ear cress) TR26036_c0_g1_i2 Q91W82 UB2E2_MOUSE 1.00E-32 GO:0005524; GO:0042296; GO:0032020; GO:0070979; GO:0070936; GO:0070534; GO:0004842 ATP binding; ISG15 ligase activity; ISG15-protein conjugation; protein K11-linked ubiquitination; protein K48-linked ubiquitination; protein K63-linked ubiquitination; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 E2 (EC 6.3.2.19) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2) Ube2e2 Mus musculus (Mouse) TR26036_c0_g2_i1 P46595 UBC4_SCHPO 2.00E-41 GO:0005524; GO:0008054; GO:0005829; GO:0000070; GO:0005634; GO:0071630; GO:0000209; GO:0016485; GO:0004842 ATP binding; cyclin catabolic process; cytosol; mitotic sister chromatid segregation; nucleus; nucleus-associated proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein processing; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 4 (EC 6.3.2.19) (Ubiquitin carrier protein 4) (Ubiquitin-protein ligase 4) ubc4 SPBC119.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR26038_c1_g1_i1 Q8BW70 UBP38_MOUSE 1.00E-13 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.4.19.12) (Deubiquitinating enzyme 38) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38) Usp38 Mus musculus (Mouse) TR26039_c2_g1_i1 P56655 CP238_MOUSE 1.00E-20 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 2C38 (EC 1.14.14.1) (CYPIIC38) Cyp2c38 Mus musculus (Mouse) TR26039_c2_g2_i2 Q27712 CP2L1_PANAR 2.00E-09 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 2L1 (EC 1.14.14.1) (CYPIIL1) CYP2L1 Panulirus argus (Caribbean spiny lobster) (Palinurus argus) TR26041_c0_g1_i1 P32240 PE2R4_MOUSE 8.00E-48 GO:0070371; GO:0007254; GO:0042093; GO:0007189; GO:0060348; GO:0071260; GO:0016021; GO:0050710; GO:2000420; GO:0050728; GO:0033624; GO:0005886; GO:0050715; GO:0050729; GO:0004957; GO:0030278; GO:0051492; GO:0032496 ERK1 and ERK2 cascade; JNK cascade; T-helper cell differentiation; adenylate cyclase-activating G-protein coupled receptor signaling pathway; bone development; cellular response to mechanical stimulus; integral to membrane; negative regulation of cytokine secretion; negative regulation of eosinophil extravasation; negative regulation of inflammatory response; negative regulation of integrin activation; plasma membrane; positive regulation of cytokine secretion; positive regulation of inflammatory response; prostaglandin E receptor activity; regulation of ossification; regulation of stress fiber assembly; response to lipopolysaccharide IPR000276; IPR017452; IPR001758; IPR008365; IPR001244; Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) Ptger4 Ptgerep4 Mus musculus (Mouse) TR26043_c0_g1_i1 Q96S96 PEBP4_HUMAN 3.00E-22 GO:0005764 P31749; P04049 lysosome IPR001858; IPR008914; Phosphatidylethanolamine-binding protein 4 (PEBP-4) (hPEBP4) (Protein cousin-of-RKIP 1) PEBP4 CORK1 UNQ1933/PRO4408 Homo sapiens (Human) TR26043_c0_g1_i2 Q9XFK7 MFT_ARATH 1.00E-18 GO:0005737; GO:0005634; GO:0010030; GO:0009737 cytoplasm; nucleus; positive regulation of seed germination; response to abscisic acid stimulus IPR001858; IPR008914; Protein MOTHER of FT and TF 1 MFT At1g18100 E12A11 T10F20.11 T10F20.7 Arabidopsis thaliana (Mouse-ear cress) TR26044_c0_g1_i1 Q502K3 ANR52_DANRE 2.00E-28 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) TR26044_c0_g2_i1 Q92625 ANS1A_HUMAN 5.00E-14 GO:0005737; GO:0048013; GO:0043005; GO:0016322; GO:0005634; GO:0006929 P00533; P04626 cytoplasm; ephrin receptor signaling pathway; neuron projection; neuron remodeling; nucleus; substrate-dependent cell migration IPR002110; IPR020683; IPR011993; IPR006020; IPR001660; IPR013761; IPR021129; Ankyrin repeat and SAM domain-containing protein 1A (Odin) ANKS1A ANKS1 KIAA0229 ODIN Homo sapiens (Human) TR26048_c1_g1_i1 Q9VUL9 FUCTA_DROME 1.00E-70 GO:0033932; GO:0032580; GO:0005797; GO:0036071; GO:0018392; GO:0016021; GO:0007399; GO:0006486 Q9VG62 "1,3-alpha-L-fucosidase activity; Golgi cisterna membrane; Golgi medial cisterna; N-glycan fucosylation; glycoprotein 3-alpha-L-fucosyltransferase activity; integral to membrane; nervous system development; protein glycosylation" IPR001503; Protein modification; protein glycosylation. "Glycoprotein 3-alpha-L-fucosyltransferase A (EC 2.4.1.214) (Core alpha-(1,3)-fucosyltransferase)" FucTA CG6869 Drosophila melanogaster (Fruit fly) TR26048_c1_g2_i1 Q8HZR3 FUT4_BOVIN 7.00E-21 GO:0032580; GO:0036065; GO:0008417; GO:0016021; GO:0006486 Golgi cisterna membrane; fucosylation; fucosyltransferase activity; integral to membrane; protein glycosylation IPR001503; Protein modification; protein glycosylation. "Alpha-(1,3)-fucosyltransferase 4 (EC 2.4.1.-) (Fucosyltransferase 4) (Fucosyltransferase IV) (Fuc-TIV) (FucT-IV) (Galactoside 3-L-fucosyltransferase)" FUT4 Bos taurus (Bovine) TR26048_c5_g1_i1 Q9VUL9 FUCTA_DROME 2.00E-41 GO:0033932; GO:0032580; GO:0005797; GO:0036071; GO:0018392; GO:0016021; GO:0007399; GO:0006486 Q9VG62 "1,3-alpha-L-fucosidase activity; Golgi cisterna membrane; Golgi medial cisterna; N-glycan fucosylation; glycoprotein 3-alpha-L-fucosyltransferase activity; integral to membrane; nervous system development; protein glycosylation" IPR001503; Protein modification; protein glycosylation. "Glycoprotein 3-alpha-L-fucosyltransferase A (EC 2.4.1.214) (Core alpha-(1,3)-fucosyltransferase)" FucTA CG6869 Drosophila melanogaster (Fruit fly) TR26050_c0_g1_i1 A9JTP3 BIRC7_XENTR 3.00E-25 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP) (Embryonic/Egg IAP) (EIAP/XLX) birc7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR26050_c1_g1_i1 Q8BM54 MYLIP_MOUSE 1.00E-07 GO:0006928; GO:0042632; GO:0005737; GO:0005856; GO:0019898; GO:0010989; GO:0007399; GO:0005886; GO:0045732; GO:0031648; GO:0042787; GO:0032803; GO:0055098; GO:0004842; GO:0008270 cellular component movement; cholesterol homeostasis; cytoplasm; cytoskeleton; extrinsic to membrane; negative regulation of low-density lipoprotein particle clearance; nervous system development; plasma membrane; positive regulation of protein catabolic process; protein destabilization; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of low-density lipoprotein particle receptor catabolic process; response to low-density lipoprotein particle stimulus; ubiquitin-protein ligase activity; zinc ion binding IPR019749; IPR019750; IPR000798; IPR014352; IPR019748; IPR000299; IPR018979; IPR011993; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MYLIP (EC 6.3.2.-) (Inducible degrader of the LDL-receptor) (Idol) (Myosin regulatory light chain-interacting protein) (MIR) Mylip Mus musculus (Mouse) TR26052_c0_g2_i1 P38225 FAT1_YEAST 3.00E-26 GO:0005783; GO:0016021; GO:0031235; GO:0005811; GO:0005324; GO:0005777; GO:0000038; GO:0031957 endoplasmic reticulum; integral to membrane; intrinsic to internal side of plasma membrane; lipid particle; long-chain fatty acid transporter activity; peroxisome; very long-chain fatty acid metabolic process; very long-chain fatty acid-CoA ligase activity IPR020845; IPR000873; Very long-chain fatty acid transport protein FAT1 YBR041W YBR0411 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR26052_c1_g1_i2 O24145 4CL1_TOBAC 3.00E-08 GO:0016207; GO:0005524; GO:0009698 4-coumarate-CoA ligase activity; ATP binding; phenylpropanoid metabolic process IPR025110; IPR020845; IPR000873; "Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2." 4-coumarate--CoA ligase 1 (4CL 1) (EC 6.2.1.12) (4-coumaroyl-CoA synthase 1) 4CL1 Nicotiana tabacum (Common tobacco) TR26052_c2_g1_i1 Q4LDG0 S27A5_MOUSE 4.00E-52 GO:0005524; GO:0009925; GO:0006699; GO:0008206; GO:0047747; GO:0005783; GO:0015245; GO:0030176; GO:0046951; GO:0004467; GO:0015911; GO:0043234; GO:0006642; GO:0000038; GO:0031957 ATP binding; basal plasma membrane; bile acid biosynthetic process; bile acid metabolic process; cholate-CoA ligase activity; endoplasmic reticulum; fatty acid transporter activity; integral to endoplasmic reticulum membrane; ketone body biosynthetic process; long-chain fatty acid-CoA ligase activity; plasma membrane long-chain fatty acid transport; protein complex; triglyceride mobilization; very long-chain fatty acid metabolic process; very long-chain fatty acid-CoA ligase activity IPR025110; IPR020845; IPR000873; Bile acyl-CoA synthetase (BACS) (EC 6.2.1.7) (Bile acid-CoA ligase) (BA-CoA ligase) (BAL) (Cholate--CoA ligase) (Fatty acid transport protein 5) (FATP-5) (Solute carrier family 27 member 5) (Very long-chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR) Slc27a5 Acsb Acsvl6 Fatp5 Vlacsr Mus musculus (Mouse) TR26052_c2_g1_i2 O88561 S27A3_MOUSE 5.00E-57 GO:0006637; GO:0004321; GO:0016021; GO:0004467; GO:0005739; GO:0000166 acyl-CoA metabolic process; fatty-acyl-CoA synthase activity; integral to membrane; long-chain fatty acid-CoA ligase activity; mitochondrion; nucleotide binding IPR025110; IPR020845; IPR000873; Long-chain fatty acid transport protein 3 (FATP-3) (Fatty acid transport protein 3) (EC 6.2.1.-) (Solute carrier family 27 member 3) Slc27a3 Acsvl3 Fatp3 Mus musculus (Mouse) TR26055_c1_g1_i1 P70684 PGDH_CAVPO 1.00E-56 GO:0016404; GO:0070403; GO:0005737; GO:0097070; GO:0007565; GO:0045786; GO:0030728; GO:0007567; GO:0004957; GO:0006693; GO:0070493; GO:0007179 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; NAD+ binding; cytoplasm; ductus arteriosus closure; female pregnancy; negative regulation of cell cycle; ovulation; parturition; prostaglandin E receptor activity; prostaglandin metabolic process; thrombin receptor signaling pathway; transforming growth factor beta receptor signaling pathway IPR002198; IPR002347; IPR016040; IPR020904; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) HPGD PGDH1 Cavia porcellus (Guinea pig) TR26057_c0_g1_i1 Q9Z0N2 IF2H_MOUSE 0 GO:0005525; GO:0006184; GO:0003924; GO:0003743 GTP binding; GTP catabolic process; GTPase activity; translation initiation factor activity IPR000795; IPR027417; IPR015256; IPR009000; IPR009001; IPR004161; "Eukaryotic translation initiation factor 2 subunit 3, Y-linked (Eukaryotic translation initiation factor 2 subunit gamma, Y-linked) (eIF-2-gamma Y)" Eif2s3y Mus musculus (Mouse) TR26059_c0_g1_i1 O97018 SXL_CHRRU 4.00E-08 GO:0003723; GO:0000166; GO:0005634 RNA binding; nucleotide binding; nucleus IPR002343; IPR012677; IPR000504; IPR006546; Sex-lethal homolog SXL Chrysomya rufifacies (Hairy maggot blowfly) (Lucilia rufifacies) TR26059_c0_g2_i1 Q7TP47 HNRPQ_RAT 4.00E-90 GO:0070937; GO:0070934; GO:0003723; GO:0008380; GO:0071013; GO:0071346; GO:0071204; GO:0006397; GO:0017148; GO:0005654; GO:0000166 CRD-mediated mRNA stability complex; CRD-mediated mRNA stabilization; RNA binding; RNA splicing; catalytic step 2 spliceosome; cellular response to interferon-gamma; histone pre-mRNA 3'end processing complex; mRNA processing; negative regulation of translation; nucleoplasm; nucleotide binding IPR006535; IPR012677; IPR000504; "Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Liver regeneration-related protein LRRG077) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein)" Syncrip Hnrpq Ab2-339 Rattus norvegicus (Rat) TR26063_c0_g1_i1 P48416 CP10_LYMST 2.00E-57 GO:0020037; GO:0005506; GO:0004497; GO:0016705 "heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Cytochrome P450 10 (EC 1.14.-.-) (CYPX) CYP10 Lymnaea stagnalis (Great pond snail) TR26065_c0_g1_i1 P31429 DPEP1_RABIT 2.00E-110 GO:0034235; GO:0031225; GO:0016999; GO:0045177; GO:0016324; GO:0071277; GO:0035690; GO:0071732; GO:0043027; GO:0008239; GO:0005615; GO:0050667; GO:0070573; GO:0031528; GO:0072341; GO:0043066; GO:0030336; GO:0005886; GO:0006508; GO:0008270 GPI anchor binding; anchored to membrane; antibiotic metabolic process; apical part of cell; apical plasma membrane; cellular response to calcium ion; cellular response to drug; cellular response to nitric oxide; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; dipeptidyl-peptidase activity; extracellular space; homocysteine metabolic process; metallodipeptidase activity; microvillus membrane; modified amino acid binding; negative regulation of apoptotic process; negative regulation of cell migration; plasma membrane; proteolysis; zinc ion binding IPR000180; IPR008257; Dipeptidase 1 (EC 3.4.13.19) (43 kDa renal band 3-related protein) (Microsomal dipeptidase) DPEP1 Oryctolagus cuniculus (Rabbit) TR26065_c0_g1_i2 C5PCN6 DPEP2_COCP7 3.00E-80 GO:0016805; GO:0008239; GO:0016021; GO:0046872; GO:0008235; GO:0006508 dipeptidase activity; dipeptidyl-peptidase activity; integral to membrane; metal ion binding; metalloexopeptidase activity; proteolysis IPR000180; IPR008257; Putative dipeptidase CPC735_014430 (EC 3.4.13.19) CPC735_014430 Coccidioides posadasii (strain C735) (Valley fever fungus) TR26069_c0_g2_i1 P0CG82 UBIQP_TETPY 3.00E-86 GO:0005737; GO:0005634 cytoplasm; nucleus IPR019956; IPR019954; IPR000626; Polyubiquitin [Cleaved into: Ubiquitin] TU20 Tetrahymena pyriformis TR26073_c0_g1_i2 Q9H0J9 PAR12_HUMAN 8.00E-11 GO:0003950; GO:0046872; GO:0005634 NAD+ ADP-ribosyltransferase activity; metal ion binding; nucleus IPR012317; IPR004170; IPR000571; Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) TR26075_c1_g1_i1 P17972 KCNAW_DROME 1.00E-24 GO:0005251; GO:0051260; GO:0030431; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; sleep; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR015572; IPR003131; IPR028325; Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) TR26075_c1_g1_i3 B1WC97 KCTD7_RAT 5.00E-06 GO:0005829; GO:0005886; GO:0051260 cytosol; plasma membrane; protein homooligomerization IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein KCTD7 Kctd7 Rattus norvegicus (Rat) TR26075_c1_g1_i4 Q8TDN2 KCNV2_HUMAN 1.00E-10 GO:0005251; GO:0005886; GO:0051260; GO:0007268; GO:0008076 delayed rectifier potassium channel activity; plasma membrane; protein homooligomerization; synaptic transmission; voltage-gated potassium channel complex IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003971; IPR003131; IPR028325; Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2) KCNV2 Homo sapiens (Human) TR26078_c3_g1_i2 Q29RY7 FGL2_BOVIN 4.00E-47 GO:0009986; GO:0005576; GO:0016504 cell surface; extracellular region; peptidase activator activity IPR014716; IPR014715; IPR002181; IPR020837; Fibroleukin (Fibrinogen-like protein 2) FGL2 Bos taurus (Bovine) TR26080_c0_g1_i1 Q5RB02 CATC_PONAB 4.00E-58 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR014882; IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] CTSC Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR26082_c0_g1_i1 P24368 PPIB_RAT 1.00E-43 GO:0005788; GO:0042470; GO:0051169; GO:0042277; GO:0003755; GO:0006457; GO:0000413; GO:0005790 endoplasmic reticulum lumen; melanosome; nuclear transport; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization; smooth endoplasmic reticulum IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) Ppib Rattus norvegicus (Rat) TR26086_c0_g1_i1 Q9VUL9 FUCTA_DROME 4.00E-33 GO:0033932; GO:0032580; GO:0005797; GO:0036071; GO:0018392; GO:0016021; GO:0007399; GO:0006486 Q9VG62 "1,3-alpha-L-fucosidase activity; Golgi cisterna membrane; Golgi medial cisterna; N-glycan fucosylation; glycoprotein 3-alpha-L-fucosyltransferase activity; integral to membrane; nervous system development; protein glycosylation" IPR001503; Protein modification; protein glycosylation. "Glycoprotein 3-alpha-L-fucosyltransferase A (EC 2.4.1.214) (Core alpha-(1,3)-fucosyltransferase)" FucTA CG6869 Drosophila melanogaster (Fruit fly) TR26089_c0_g1_i2 A8WGS4 TLCD2_DANRE 2.00E-08 GO:0016021 integral to membrane IPR006634; TLC domain-containing protein 2 tlcd2 zgc:175098 Danio rerio (Zebrafish) (Brachydanio rerio) TR26094_c1_g1_i1 Q8N5R6 CCD33_HUMAN 5.00E-20 Q96ED9 IPR000008; Coiled-coil domain-containing protein 33 (Cancer/testis antigen 61) (CT61) CCDC33 Homo sapiens (Human) TR26094_c2_g1_i1 Q8N5R6 CCD33_HUMAN 4.00E-08 Q96ED9 IPR000008; Coiled-coil domain-containing protein 33 (Cancer/testis antigen 61) (CT61) CCDC33 Homo sapiens (Human) TR26094_c2_g1_i2 Q5XIR4 CCD33_RAT 1.00E-09 IPR000008; Coiled-coil domain-containing protein 33 Ccdc33 Rattus norvegicus (Rat) TR26095_c0_g1_i1 Q8N5G0 CD052_HUMAN 7.00E-09 GO:0016021 integral to membrane IPR027917; Small integral membrane protein 20 SMIM20 C4orf52 Homo sapiens (Human) TR26097_c2_g1_i1 P38661 PDIA6_MEDSA 1.00E-07 GO:0045454; GO:0005788; GO:0006662; GO:0003756; GO:0015035; GO:0006457 cell redox homeostasis; endoplasmic reticulum lumen; glycerol ether metabolic process; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; protein folding IPR005788; IPR011679; IPR005746; IPR012336; IPR017937; IPR013766; Probable protein disulfide-isomerase A6 (EC 5.3.4.1) (P5) Medicago sativa (Alfalfa) TR26103_c0_g1_i1 P70541 EI2BG_RAT 3.00E-118 GO:0005851; GO:0005085; GO:0032057; GO:0016779; GO:0014003; GO:0009749; GO:0009408; GO:0043434; GO:0003743; GO:0006413 eukaryotic translation initiation factor 2B complex; guanyl-nucleotide exchange factor activity; negative regulation of translational initiation in response to stress; nucleotidyltransferase activity; oligodendrocyte development; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translation initiation factor activity; translational initiation IPR005835; Translation initiation factor eIF-2B subunit gamma (eIF-2B GDP-GTP exchange factor subunit gamma) Eif2b3 Eif2bg Rattus norvegicus (Rat) TR26105_c0_g1_i1 Q2TAC6 KIF19_HUMAN 3.00E-11 GO:0005524; GO:0060404; GO:0005929; GO:0005737; GO:0005871; GO:0005874; GO:0007018; GO:0070462; GO:0008574 ATP binding; axonemal microtubule depolymerization; cilium; cytoplasm; kinesin complex; microtubule; microtubule-based movement; plus-end specific microtubule depolymerization; plus-end-directed microtubule motor activity IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF19 KIF19 Homo sapiens (Human) TR26105_c2_g2_i1 Q8T135 KIF5_DICDI 6.00E-13 GO:0005524; GO:0051015; GO:0051017; GO:0005737; GO:0005871; GO:0005874; GO:0008017; GO:0003777; GO:0007018; GO:0006810 ATP binding; actin filament binding; actin filament bundle assembly; cytoplasm; kinesin complex; microtubule; microtubule binding; microtubule motor activity; microtubule-based movement; transport IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-related protein 5 (Kinesin family member 5) (Kinesin-1) kif5 kin5 DDB_G0276369 Dictyostelium discoideum (Slime mold) TR26106_c0_g1_i1 Q9D2H2 KAD7_MOUSE 1.00E-152 GO:0005524; GO:0004017; GO:0007420; GO:0035083; GO:0004127; GO:0005829; GO:0003351; GO:0002437; GO:0004550; GO:0009142; GO:0007283 ATP binding; adenylate kinase activity; brain development; cilium axoneme assembly; cytidylate kinase activity; cytosol; epithelial cilium movement; inflammatory response to antigenic stimulus; nucleoside diphosphate kinase activity; nucleoside triphosphate biosynthetic process; spermatogenesis IPR000850; IPR007858; IPR016040; IPR027417; Adenylate kinase 7 (AK 7) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 7) Ak7 Mus musculus (Mouse) TR26114_c3_g1_i1 Q9R0W5 ASIC5_RAT 5.00E-06 GO:0016021; GO:0015280; GO:0005886 integral to membrane; ligand-gated sodium channel activity; plasma membrane IPR001873; Acid-sensing ion channel 5 (ASIC5) (Amiloride-sensitive cation channel 5) (Brain-liver-intestine amiloride-sensitive Na(+) channel) (BLINaC) Asic5 Accn5 Blinac Rattus norvegicus (Rat) TR26116_c0_g1_i1 Q969N2 PIGT_HUMAN 1.00E-123 GO:0006501; GO:0003923; GO:0042765; GO:0016255; GO:0016023; GO:0051402; GO:0030182 C-terminal protein lipidation; GPI-anchor transamidase activity; GPI-anchor transamidase complex; attachment of GPI anchor to protein; cytoplasmic membrane-bounded vesicle; neuron apoptotic process; neuron differentiation IPR007245; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. GPI transamidase component PIG-T (Phosphatidylinositol-glycan biosynthesis class T protein) PIGT CGI-06 PSEC0163 UNQ716/PRO1379 Homo sapiens (Human) TR26116_c0_g1_i2 Q969N2 PIGT_HUMAN 2.00E-155 GO:0006501; GO:0003923; GO:0042765; GO:0016255; GO:0016023; GO:0051402; GO:0030182 C-terminal protein lipidation; GPI-anchor transamidase activity; GPI-anchor transamidase complex; attachment of GPI anchor to protein; cytoplasmic membrane-bounded vesicle; neuron apoptotic process; neuron differentiation IPR007245; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. GPI transamidase component PIG-T (Phosphatidylinositol-glycan biosynthesis class T protein) PIGT CGI-06 PSEC0163 UNQ716/PRO1379 Homo sapiens (Human) TR26121_c1_g1_i1 O18635 C12A2_MUSDO 2.00E-38 GO:0020037; GO:0005506; GO:0004497; GO:0016705 "heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Cytochrome P450 CYP12A2 (EC 1.14.-.-) (CYPXIIA2) CYP12A2 Musca domestica (House fly) TR26126_c3_g1_i1 Q5TB80 QN1_HUMAN 3.00E-27 GO:0005879; GO:0005814; GO:0042384; GO:0005634; GO:0005886; GO:0005819 axonemal microtubule; centriole; cilium assembly; nucleus; plasma membrane; spindle Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog) KIAA1009 C6orf84 CEP162 QN1 Homo sapiens (Human) TR26126_c4_g2_i1 Q91365 QN1_COTCO 3.00E-19 GO:0005879; GO:0005814; GO:0042384; GO:0005634 axonemal microtubule; centriole; cilium assembly; nucleus Centrosomal protein of 162 kDa (Cep162) (Protein quail neuroretina 1) (Fragment) CEP162 QN1 Coturnix coturnix (Common quail) (Tetrao coturnix) TR26130_c0_g1_i1 P24387 CRHBP_HUMAN 7.00E-41 GO:0043679; GO:0048149; GO:0071320; GO:0071277; GO:0071314; GO:0035690; GO:0071392; GO:0097211; GO:0035865; GO:0033554; GO:0071356; GO:0051424; GO:0030425; GO:0031045; GO:0005615; GO:0007565; GO:0042445; GO:0009755; GO:0006954; GO:0007611; GO:0002125; GO:0005874; GO:0005771; GO:0051460; GO:1900011; GO:0005634; GO:0043204; GO:0045055; GO:2000310; GO:0050795; GO:0005767; GO:0001963; GO:0043196 "axon terminus; behavioral response to ethanol; cellular response to cAMP; cellular response to calcium ion; cellular response to cocaine; cellular response to drug; cellular response to estradiol stimulus; cellular response to gonadotropin-releasing hormone; cellular response to potassium ion; cellular response to stress; cellular response to tumor necrosis factor; corticotropin-releasing hormone binding; dendrite; dense core granule; extracellular space; female pregnancy; hormone metabolic process; hormone-mediated signaling pathway; inflammatory response; learning or memory; maternal aggressive behavior; microtubule; multivesicular body; negative regulation of corticotropin secretion; negative regulation of corticotropin-releasing hormone receptor activity; nucleus; perikaryon; regulated secretory pathway; regulation of N-methyl-D-aspartate selective glutamate receptor activity; regulation of behavior; secondary lysosome; synaptic transmission, dopaminergic; varicosity" IPR008435; IPR000859; Corticotropin-releasing factor-binding protein (CRF-BP) (CRF-binding protein) (Corticotropin-releasing hormone-binding protein) (CRH-BP) CRHBP CRFBP Homo sapiens (Human) TR26131_c2_g1_i1 Q96C23 GALM_HUMAN 1.00E-45 GO:0004034; GO:0030246; GO:0005737; GO:0019318 aldose 1-epimerase activity; carbohydrate binding; cytoplasm; hexose metabolic process IPR018052; IPR015443; IPR008183; IPR011013; IPR014718; Carbohydrate metabolism; hexose metabolism. Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase) GALM BLOCK25 Homo sapiens (Human) TR26131_c2_g1_i2 Q5EA79 GALM_BOVIN 4.00E-50 GO:0004034; GO:0030246; GO:0005737; GO:0019318 aldose 1-epimerase activity; carbohydrate binding; cytoplasm; hexose metabolic process IPR018052; IPR015443; IPR008183; IPR011013; IPR014718; Carbohydrate metabolism; hexose metabolism. Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase) GALM Bos taurus (Bovine) TR26134_c1_g1_i2 Q8CQD9 PLS_STAES 2.00E-11 GO:0005618; GO:0005576; GO:0016020 cell wall; extracellular region; membrane IPR011098; IPR005877; IPR019948; IPR019931; Accumulation-associated protein SE_0175 Staphylococcus epidermidis (strain ATCC 12228) TR26135_c1_g1_i1 A6PW82 CX030_HUMAN 6.00E-56 Putative uncharacterized protein CXorf30 CXorf30 Homo sapiens (Human) TR26138_c2_g2_i2 Q9D4W2 CK065_MOUSE 3.00E-77 Uncharacterized protein C11orf65 homolog Mus musculus (Mouse) TR26141_c0_g2_i1 Q69CM7 MYBPP_RAT 5.00E-07 GO:0030154; GO:0005737; GO:0019897; GO:0007275; GO:0007605; GO:0007283; GO:0007268 cell differentiation; cytoplasm; extrinsic to plasma membrane; multicellular organismal development; sensory perception of sound; spermatogenesis; synaptic transmission MYCBP-associated protein (Organ of Corti membrane-associated protein of 106 kDa) Mycbpap Cod106 Rattus norvegicus (Rat) TR26141_c1_g1_i1 Q8TBZ2 MYBPP_HUMAN 2.00E-10 GO:0030154; GO:0005737; GO:0016020; GO:0007275; GO:0007283; GO:0007268 Q99417 cell differentiation; cytoplasm; membrane; multicellular organismal development; spermatogenesis; synaptic transmission MYCBP-associated protein (AMAM-1) (AMY-1-binding protein 1) (AMAP-1) MYCBPAP AMAP1 Homo sapiens (Human) TR26142_c0_g1_i2 Q5XFX0 TAGL2_RAT 1.00E-10 GO:0007517 muscle organ development IPR000557; IPR001715; IPR003096; IPR001061; Transgelin-2 Tagln2 Rattus norvegicus (Rat) TR26144_c3_g1_i1 A4IT60 KYNB_GEOTN 8.00E-08 GO:0043420; GO:0004061; GO:0004328; GO:0019441 anthranilate metabolic process; arylformamidase activity; formamidase activity; tryptophan catabolic process to kynurenine IPR007325; IPR017484; Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. Kynurenine formamidase (KFA) (KFase) (EC 3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF) kynB GTNG_3169 Geobacillus thermodenitrificans (strain NG80-2) TR26145_c1_g1_i1 Q8JHV9 BIR7A_XENLA 1.00E-50 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR26148_c0_g1_i1 Q9ULJ8 NEB1_HUMAN 9.00E-38 GO:0007015; GO:0019722; GO:0030054; GO:0030864; GO:0043197; GO:0030175; GO:0030426; GO:0031175; GO:0045202 P41220 actin filament organization; calcium-mediated signaling; cell junction; cortical actin cytoskeleton; dendritic spine; filopodium; growth cone; neuron projection development; synapse IPR001478; IPR001660; IPR013761; IPR011510; Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A) PPP1R9A KIAA1222 Homo sapiens (Human) TR26156_c2_g2_i1 Q60HE9 MA2B1_MACFA 1.00E-124 GO:0004559; GO:0030246; GO:0005764; GO:0006013; GO:0008270 alpha-mannosidase activity; carbohydrate binding; lysosome; mannose metabolic process; zinc ion binding IPR011013; IPR011330; IPR013780; IPR027291; IPR011682; IPR015341; IPR000602; Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) MAN2B1 QmoA-10471 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR26157_c0_g1_i1 A8WGS4 TLCD2_DANRE 3.00E-08 GO:0016021 integral to membrane IPR006634; TLC domain-containing protein 2 tlcd2 zgc:175098 Danio rerio (Zebrafish) (Brachydanio rerio) TR26159_c0_g1_i2 Q5F359 TPPC5_CHICK 3.00E-83 GO:0005794; GO:0030008; GO:0005783; GO:0016192 Golgi apparatus; TRAPP complex; endoplasmic reticulum; vesicle-mediated transport IPR024096; IPR016696; IPR007194; Trafficking protein particle complex subunit 5 TRAPPC5 RCJMB04_33f11 Gallus gallus (Chicken) TR26160_c0_g1_i1 Q54PZ6 Y5897_DICDI 2.00E-10 GO:0005096; GO:0043547 GTPase activator activity; positive regulation of GTPase activity IPR003123; Putative uncharacterized protein DDB_G0284213 DDB_G0284213 Dictyostelium discoideum (Slime mold) TR26162_c1_g1_i1 P14893 3BHS_BOVIN 2.00E-40 GO:0003854; GO:0016021; GO:0031966; GO:0030868; GO:0006694; GO:0004769 3-beta-hydroxy-delta5-steroid dehydrogenase activity; integral to membrane; mitochondrial membrane; smooth endoplasmic reticulum membrane; steroid biosynthetic process; steroid delta-isomerase activity IPR002225; IPR016040; Lipid metabolism; steroid biosynthesis. 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase (3-beta-HSD) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)] HSD3B Bos taurus (Bovine) TR26166_c1_g1_i2 Q9BYK8 PR285_HUMAN 6.00E-30 GO:0005524; GO:0003677; GO:0044255; GO:0004386; GO:0030374; GO:0046872; GO:0005654; GO:0045944; GO:0044281; GO:0006351 "ATP binding; DNA binding; cellular lipid metabolic process; helicase activity; ligand-dependent nuclear receptor transcription coactivator activity; metal ion binding; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; small molecule metabolic process; transcription, DNA-dependent" IPR003593; IPR026122; IPR012340; IPR027417; IPR022966; IPR015880; "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) TR26168_c4_g1_i1 Q9Y2M2 CC032_HUMAN 1.00E-19 GO:0005737 cytoplasm Protein SSUH2 homolog (Protein ssu-2 homolog) SSUH2 C3orf32 FLS485 Homo sapiens (Human) TR26168_c6_g2_i1 Q8C3L1 CC032_MOUSE 1.00E-37 GO:0005737 cytoplasm IPR001305; Protein SSUH2 homolog (Protein ssu-2 homolog) Ssuh2 Ssu2 Mus musculus (Mouse) TR26172_c0_g1_i1 P38565 MUCB1_XENLA 1.00E-08 GO:0005576 extracellular region IPR006208; IPR006207; IPR001007; Integumentary mucin B.1 (FIM-B.1) (Fragment) Xenopus laevis (African clawed frog) TR26172_c0_g1_i2 P38565 MUCB1_XENLA 2.00E-08 GO:0005576 extracellular region IPR006208; IPR006207; IPR001007; Integumentary mucin B.1 (FIM-B.1) (Fragment) Xenopus laevis (African clawed frog) TR26187_c1_g1_i1 Q8AWB5 FUT10_CHICK 2.00E-46 GO:0032580; GO:0046920; GO:0036065; GO:0016021; GO:0006486 Golgi cisterna membrane; alpha-(1->3)-fucosyltransferase activity; fucosylation; integral to membrane; protein glycosylation IPR017176; IPR001503; Protein modification; protein glycosylation. "Alpha-(1,3)-fucosyltransferase 10 (EC 2.4.1.-) (Fucosyltransferase X) (Fuc-TX) (FucT-X) (Galactoside 3-L-fucosyltransferase 10) (Fucosyltransferase 10)" FUT10 Gallus gallus (Chicken) TR26187_c1_g1_i2 Q5F2N3 FUT10_DANRE 9.00E-44 GO:0032580; GO:0046920; GO:0036065; GO:0016021; GO:0006486 Golgi cisterna membrane; alpha-(1->3)-fucosyltransferase activity; fucosylation; integral to membrane; protein glycosylation IPR017176; IPR001503; Protein modification; protein glycosylation. "Alpha-(1,3)-fucosyltransferase 10 (EC 2.4.1.-) (Fucosyltransferase X) (Fuc-TX) (FucT-X) (Galactoside 3-L-fucosyltransferase 10) (Fucosyltransferase 10)" fut10 zgc:195147 Danio rerio (Zebrafish) (Brachydanio rerio) TR26188_c2_g1_i1 P24524 GLRA3_RAT 1.00E-66 GO:0030054; GO:0034707; GO:0016934; GO:0016594; GO:0005887; GO:0045211; GO:0022824 cell junction; chloride channel complex; extracellular-glycine-gated chloride channel activity; glycine binding; integral to plasma membrane; postsynaptic membrane; transmitter-gated ion channel activity IPR006028; IPR008127; IPR008130; IPR006202; IPR006201; IPR006029; IPR018000; Glycine receptor subunit alpha-3 Glra3 Rattus norvegicus (Rat) TR26188_c2_g1_i3 Q5IS75 ACHB3_PANTR 5.00E-10 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit beta-3 CHRNB3 Pan troglodytes (Chimpanzee) TR26190_c0_g1_i1 P97493 THIOM_MOUSE 1.00E-40 GO:0045454; GO:0031669; GO:0030425; GO:0006662; GO:0005739; GO:0043025; GO:0005730; GO:0015035; GO:0048678; GO:0042493; GO:0009749; GO:0009725; GO:0001666; GO:0007584; GO:0014070; GO:0006979 cell redox homeostasis; cellular response to nutrient levels; dendrite; glycerol ether metabolic process; mitochondrion; neuronal cell body; nucleolus; protein disulfide oxidoreductase activity; response to axon injury; response to drug; response to glucose stimulus; response to hormone stimulus; response to hypoxia; response to nutrient; response to organic cyclic compound; response to oxidative stress IPR005746; IPR012336; IPR017937; IPR013766; "Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)" Txn2 Mus musculus (Mouse) TR26190_c0_g1_i2 Q6NPF9 TRXY1_ARATH 2.00E-14 GO:0045454; GO:0009570; GO:0008047; GO:0006662; GO:0016671; GO:0015035 "cell redox homeostasis; chloroplast stroma; enzyme activator activity; glycerol ether metabolic process; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; protein disulfide oxidoreductase activity" IPR005746; IPR012336; IPR017937; IPR013766; "Thioredoxin Y1, chloroplastic (AtTrxy1)" At1g76760 F28O16.13 Arabidopsis thaliana (Mouse-ear cress) TR26194_c0_g1_i1 P16423 POLR_DROME 9.00E-16 GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0046872; GO:0090305; GO:0006508 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR000477; IPR007087; IPR015880; Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM (Retrovirus-related Pol polyprotein from type II retrotransposable element R2DM) [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR26194_c1_g2_i1 P41366 VMO1_CHICK 6.00E-10 GO:0005576; GO:0030704 extracellular region; vitelline membrane formation IPR005515; Vitelline membrane outer layer protein 1 (VMO-1) (VMO-I) (VMOI) VMO1 Gallus gallus (Chicken) TR26196_c0_g1_i1 Q5W0B1 RN219_HUMAN 5.00E-33 GO:0008270 zinc ion binding IPR001841; IPR013083; RING finger protein 219 RNF219 C13orf7 Homo sapiens (Human) TR26198_c2_g1_i1 Q8N468 MFSD4_HUMAN 3.00E-13 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR016196; Major facilitator superfamily domain-containing protein 4 MFSD4 UNQ3064/PRO9894 Homo sapiens (Human) TR26200_c0_g1_i1 P63326 RS10_RAT 2.00E-56 GO:0022627; GO:0005730; GO:0000028; GO:0003735 cytosolic small ribosomal subunit; nucleolus; ribosomal small subunit assembly; structural constituent of ribosome IPR005326; 40S ribosomal protein S10 Rps10 Rattus norvegicus (Rat) TR26201_c5_g1_i1 Q99550 MPP9_HUMAN 6.00E-12 GO:0005794; GO:0000139; GO:0005814; GO:0000087; GO:0005634; GO:0005886 Golgi apparatus; Golgi membrane; centriole; mitotic M phase; nucleus; plasma membrane IPR026636; M-phase phosphoprotein 9 MPHOSPH9 MPP9 Homo sapiens (Human) TR26205_c0_g1_i1 P60204 CALM_EMENI 1.00E-27 GO:0005509; GO:0001411; GO:0051726; GO:0009847 calcium ion binding; hyphal tip; regulation of cell cycle; spore germination IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) camA cam AN2047 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR26206_c0_g1_i1 Q2YGT9 RL6_PIG 4.00E-72 GO:0022625; GO:0003735; GO:0006412 cytosolic large ribosomal subunit; structural constituent of ribosome; translation IPR000915; IPR014722; IPR005568; IPR008991; 60S ribosomal protein L6 RPL6 Sus scrofa (Pig) TR26207_c0_g1_i1 Q7ZWE7 NOL12_DANRE 8.00E-11 GO:0005730; GO:0019843 nucleolus; rRNA binding IPR019186; Nucleolar protein 12 nol12 zgc:56457 Danio rerio (Zebrafish) (Brachydanio rerio) TR26207_c0_g1_i2 Q5D1Z3 NOL12_RAT 4.00E-11 GO:0005730; GO:0019843 nucleolus; rRNA binding IPR019186; Nucleolar protein 12 (25 kDa nucleolar protein) Nol12 Nop25 Rattus norvegicus (Rat) TR26210_c1_g1_i1 O22845 CML5_ARATH 3.00E-10 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-like protein 5 (Protein MULTICOPY SUPPRESSORS OF SNF4 DEFICIENCY IN YEAST 3) CML5 MSS3 At2g43290 F14B2.33 T1O24.3 Arabidopsis thaliana (Mouse-ear cress) TR26211_c2_g1_i1 P16152 CBR1_HUMAN 2.00E-56 GO:0047021; GO:0004090; GO:0019371; GO:0005829; GO:0017144; GO:0016655; GO:0050221; GO:0042373 "15-hydroxyprostaglandin dehydrogenase (NADP+) activity; carbonyl reductase (NADPH) activity; cyclooxygenase pathway; cytosol; drug metabolic process; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; prostaglandin-E2 9-reductase activity; vitamin K metabolic process" IPR002198; IPR002347; IPR016040; IPR020904; Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.197) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) CBR1 CBR CRN Homo sapiens (Human) TR26213_c1_g1_i1 P70569 MYO5B_RAT 4.00E-32 GO:0005524; GO:0017137; GO:0043197; GO:0003774; GO:0016459; GO:0043025; GO:0048471; GO:0015031; GO:0032880 P19490 ATP binding; Rab GTPase binding; dendritic spine; motor activity; myosin complex; neuronal cell body; perinuclear region of cytoplasm; protein transport; regulation of protein localization IPR018444; IPR002710; IPR000048; IPR001609; IPR027417; Unconventional myosin-Vb (Myosin heavy chain myr 6) Myo5b Rattus norvegicus (Rat) TR26213_c3_g1_i1 Q02440 MYO5A_CHICK 1.00E-23 GO:0005524; GO:0000139; GO:0032869; GO:0031941; GO:0032593; GO:0060001; GO:0016459; GO:0072659; GO:0016192 P14649 ATP binding; Golgi membrane; cellular response to insulin stimulus; filamentous actin; insulin-responsive compartment; minus-end directed microfilament motor activity; myosin complex; protein localization to plasma membrane; vesicle-mediated transport IPR018444; IPR002710; IPR000048; IPR001609; IPR027417; "Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain p190) (Myosin-V)" MYO5A Gallus gallus (Chicken) TR26215_c1_g1_i1 Q6IMI6 ST1C3_HUMAN 3.00E-37 GO:0004027; GO:0004062; GO:0005737; GO:0006790 alcohol sulfotransferase activity; aryl sulfotransferase activity; cytoplasm; sulfur compound metabolic process IPR027417; IPR000863; Sulfotransferase 1C3 (ST1C3) (EC 2.8.2.2) SULT1C3 Homo sapiens (Human) TR26217_c1_g1_i1 P25207 NFYB_CHICK 2.00E-70 GO:0016602; GO:0006355; GO:0043565; GO:0006351 "CCAAT-binding factor complex; regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription, DNA-dependent" IPR003958; IPR009072; IPR003957; IPR003956; Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB) NFYB RCJMB04_7n24 Gallus gallus (Chicken) TR26218_c1_g1_i1 Q99549 MPP8_HUMAN 5.00E-09 GO:0007049; GO:0005737; GO:0035064; GO:0045892; GO:0005720; GO:0000788; GO:0005730; GO:0005886; GO:0044030; GO:0006351 Q9H9B1; P68431; Q15047 "cell cycle; cytoplasm; methylated histone residue binding; negative regulation of transcription, DNA-dependent; nuclear heterochromatin; nuclear nucleosome; nucleolus; plasma membrane; regulation of DNA methylation; transcription, DNA-dependent" IPR002110; IPR020683; IPR023780; IPR000953; IPR016197; IPR023779; M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) MPHOSPH8 MPP8 Homo sapiens (Human) TR26219_c0_g1_i2 Q503L9 NXN_DANRE 4.00E-34 GO:0016055; GO:0072358; GO:0030154; GO:0005829; GO:0030178; GO:0031397; GO:0005634; GO:0047134 Wnt receptor signaling pathway; cardiovascular system development; cell differentiation; cytosol; negative regulation of Wnt receptor signaling pathway; negative regulation of protein ubiquitination; nucleus; protein-disulfide reductase activity IPR012336; Nucleoredoxin (EC 1.8.1.8) nxn zgc:110449 Danio rerio (Zebrafish) (Brachydanio rerio) TR26221_c0_g1_i1 P55212 CASP6_HUMAN 3.00E-16 GO:0006921; GO:0004197; GO:0005829; GO:0005654; GO:0006508 Itself; Q01826 cellular component disassembly involved in execution phase of apoptosis; cysteine-type endopeptidase activity; cytosol; nucleoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11] CASP6 MCH2 Homo sapiens (Human) TR26223_c0_g1_i1 Q1HPL8 NDUBA_BOMMO 2.00E-44 GO:0005743; GO:0055114; GO:0070469 mitochondrial inner membrane; oxidation-reduction process; respiratory chain IPR019377; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 Bombyx mori (Silk moth) TR26230_c0_g1_i1 Q8BPB5 FBLN3_MOUSE 3.00E-12 GO:0005509; GO:0005154; GO:0005006; GO:0005615; GO:0032331; GO:0005578; GO:0006355 "calcium ion binding; epidermal growth factor receptor binding; epidermal growth factor-activated receptor activity; extracellular space; negative regulation of chondrocyte differentiation; proteinaceous extracellular matrix; regulation of transcription, DNA-dependent" IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; EGF-containing fibulin-like extracellular matrix protein 1 (Fibulin-3) (FIBL-3) Efemp1 Fbln3 Mus musculus (Mouse) TR26232_c2_g1_i1 Q5XH48 EDC3_XENLA 1.00E-51 GO:0003723; GO:0000932 RNA binding; cytoplasmic mRNA processing body IPR025762; IPR019050; IPR025609; IPR004443; Enhancer of mRNA-decapping protein 3 (YjeF domain-containing protein 1) edc3 yjdc Xenopus laevis (African clawed frog) TR26232_c6_g1_i1 Q5RDU9 EDC3_PONAB 9.00E-27 GO:0003723; GO:0000932 RNA binding; cytoplasmic mRNA processing body IPR025762; IPR019050; IPR025609; IPR004443; Enhancer of mRNA-decapping protein 3 (YjeF domain-containing protein 1) EDC3 YJDC Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR26237_c1_g1_i2 Q8C8H8 KY_MOUSE 2.00E-11 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) TR26238_c1_g1_i1 Q2TU62 CLCA1_HORSE 3.00E-48 GO:0006816; GO:0005615; GO:0016021; GO:0030141 calcium ion transport; extracellular space; integral to membrane; secretory granule IPR004727; IPR013642; IPR015394; IPR002035; Calcium-activated chloride channel regulator 1 (Calcium-activated chloride channel family member 1) (eCLCA1) CLCA1 Equus caballus (Horse) TR26240_c3_g1_i1 Q86YQ8 CPNE8_HUMAN 7.00E-62 IPR000008; IPR010734; IPR002035; Copine-8 (Copine VIII) CPNE8 Homo sapiens (Human) TR26240_c5_g1_i1 Q86YQ8 CPNE8_HUMAN 2.00E-122 IPR000008; IPR010734; IPR002035; Copine-8 (Copine VIII) CPNE8 Homo sapiens (Human) TR26244_c3_g1_i1 P83093 STIM2_MOUSE 3.00E-48 GO:0032237; GO:0005246; GO:0005509; GO:0006874; GO:0005783; GO:0005789; GO:0016021; GO:0005886; GO:0051928; GO:0015279 activation of store-operated calcium channel activity; calcium channel regulator activity; calcium ion binding; cellular calcium ion homeostasis; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; plasma membrane; positive regulation of calcium ion transport; store-operated calcium channel activity IPR001660; IPR013761; IPR011510; Stromal interaction molecule 2 Stim2 Kiaa1482 Mus musculus (Mouse) TR26246_c0_g2_i1 Q6L711 HABP2_RAT 1.00E-12 GO:0005576; GO:0006508; GO:0004252 extracellular region; proteolysis; serine-type endopeptidase activity IPR000742; IPR013032; IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR009003; Hyaluronan-binding protein 2 (EC 3.4.21.-) (Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form] Habp2 Phbp Rattus norvegicus (Rat) TR26246_c0_g2_i2 Q99MS4 PRS29_MOUSE 2.00E-16 GO:0005576; GO:0006508; GO:0004252 extracellular region; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Serine protease 29 (EC 3.4.21.-) (Implantation serine proteinase 2) (ISP-2) (Strypsin-2) (Strypsin-related protein) (Tryptase-like proteinase) Prss29 Isp2 Mus musculus (Mouse) TR26247_c0_g1_i1 Q6GMD3 CS066_XENLA 2.00E-38 IPR026795; UPF0515 protein C19orf66 homolog Xenopus laevis (African clawed frog) TR26247_c0_g1_i2 Q5RJN4 CS066_RAT 2.00E-20 IPR026795; UPF0515 protein C19orf66 homolog Rattus norvegicus (Rat) TR26249_c2_g1_i1 Q9UJU3 ZF112_HUMAN 2.00E-26 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 112 (Zfp-112) (Zinc finger protein 228) ZNF112 ZFP112 ZNF228 Homo sapiens (Human) TR26253_c2_g1_i1 Q1LY77 SE1BA_DANRE 7.00E-104 GO:0003723; GO:0005694; GO:0034968; GO:0018024; GO:0016607; GO:0000166; GO:0006355; GO:0006351 "RNA binding; chromosome; histone lysine methylation; histone-lysine N-methyltransferase activity; nuclear speck; nucleotide binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR024657; IPR015722; IPR012677; IPR003616; IPR000504; IPR001214; Histone-lysine N-methyltransferase SETD1B-A (EC 2.1.1.43) (SET domain-containing protein 1B-A) setd1ba setd1b si:dkey-237o15.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR26261_c1_g1_i1 Q9FT73 MED34_ARATH 6.00E-32 GO:0043138; GO:0005524; GO:0043140; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0009378; GO:0016592; GO:0046872; GO:0006355; GO:0006351 "3'-5' DNA helicase activity; ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA binding; DNA recombination; DNA repair; DNA replication; four-way junction helicase activity; mediator complex; metal ion binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011545; IPR004589; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR018982; IPR011991; Mediator of RNA polymerase II transcription subunit 34 (ATP-dependent DNA helicase Q-like 2) (EC 3.6.4.12) (RecQ-like protein 2) (AtRecQ2) (AtRecQl2) MED34 MED34_1 RECQ2 RECQL2 RQL2 At1g31360 T19E23.16 Arabidopsis thaliana (Mouse-ear cress) TR26261_c1_g1_i3 Q0UG00 MS116_PHANO 8.00E-09 GO:0005524; GO:0008026; GO:0003723; GO:0008380; GO:0006397; GO:0005759; GO:0006417 ATP binding; ATP-dependent helicase activity; RNA binding; RNA splicing; mRNA processing; mitochondrial matrix; regulation of translation IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; "ATP-dependent RNA helicase MSS116, mitochondrial (EC 3.6.4.13)" MSS116 SNOG_09314 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum) TR26263_c1_g1_i1 Q96514 C71B7_ARATH 1.00E-30 GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705 "heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Cytochrome P450 71B7 (EC 1.14.-.-) CYP71B7 At1g13110 F3F19.13 Arabidopsis thaliana (Mouse-ear cress) TR26263_c1_g1_i2 O18993 CP3AL_CALJA 2.00E-121 GO:0070330; GO:0005789; GO:0020037; GO:0005506; GO:0004497 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity IPR001128; IPR017972; IPR008072; IPR002402; Cytochrome P450 3A21 (EC 1.14.14.1) (CYPIIIA21) (Cytochrome P450 CM3A-10) CYP3A21 Callithrix jacchus (White-tufted-ear marmoset) TR26264_c0_g1_i1 Q9C0G0 ZN407_HUMAN 1.00E-07 GO:0003677; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR007087; IPR015880; IPR013087; IPR003604; Zinc finger protein 407 ZNF407 KIAA1703 Homo sapiens (Human) TR26264_c0_g2_i1 Q9C0G0 ZN407_HUMAN 4.00E-07 GO:0003677; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR007087; IPR015880; IPR013087; IPR003604; Zinc finger protein 407 ZNF407 KIAA1703 Homo sapiens (Human) TR26268_c0_g1_i1 Q9CWQ0 DPH5_MOUSE 3.00E-141 GO:0004164; GO:0017183 diphthine synthase activity; peptidyl-diphthamide biosynthetic process from peptidyl-histidine IPR000878; IPR014777; IPR014776; IPR004551; Protein modification; peptidyl-diphthamide biosynthesis. Diphthine synthase (EC 2.1.1.98) (Diphthamide biosynthesis methyltransferase) Dph5 Mus musculus (Mouse) TR2627_c0_g1_i1 Q9BXI9 C1QT6_HUMAN 2.00E-07 GO:0005581; GO:0005615; GO:0070208 collagen; extracellular space; protein heterotrimerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 6 C1QTNF6 CTRP6 UNQ581/PRO1151 Homo sapiens (Human) TR26270_c0_g1_i1 O97341 CALM_SUBDO 7.00E-25 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) Suberites domuncula (Sponge) TR26270_c0_g1_i2 P04352 CALM_CHLRE 3.00E-39 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Chlamydomonas reinhardtii (Chlamydomonas smithii) TR26270_c0_g1_i3 Q32LE3 CETN1_BOVIN 5.00E-23 GO:0005524; GO:0008026; GO:0005509; GO:0051301; GO:0034605; GO:0005813; GO:0005737; GO:0007067; GO:0003676; GO:0032391; GO:0000922 ATP binding; ATP-dependent helicase activity; calcium ion binding; cell division; cellular response to heat; centrosome; cytoplasm; mitosis; nucleic acid binding; photoreceptor connecting cilium; spindle pole IPR011992; IPR018247; IPR002048; IPR000629; Centrin-1 CETN1 Bos taurus (Bovine) TR26273_c1_g2_i1 Q6ICB0 DESI1_HUMAN 2.00E-63 GO:0005737; GO:0005634; GO:0008233; GO:0006508 cytoplasm; nucleus; peptidase activity; proteolysis IPR008580; Desumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 2) (Protein FAM152B) DESI1 FAM152B PPPDE2 Homo sapiens (Human) TR26277_c3_g1_i1 Q569A2 TSN12_RAT 3.00E-08 GO:0001525; GO:0007166; GO:0005887; GO:0045765; GO:0010842 angiogenesis; cell surface receptor signaling pathway; integral to plasma membrane; regulation of angiogenesis; retina layer formation IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-12 (Tspan-12) (Transmembrane 4 superfamily member 12) Tspan12 Tm4sf12 Rattus norvegicus (Rat) TR26278_c0_g2_i2 P20065 TYB4_MOUSE 2.00E-15 GO:0030036; GO:0005856; GO:0005829; GO:0005634; GO:0051152; GO:0014911; GO:0045893; GO:0042989 Q8WWQ8 "actin cytoskeleton organization; cytoskeleton; cytosol; nucleus; positive regulation of smooth muscle cell differentiation; positive regulation of smooth muscle cell migration; positive regulation of transcription, DNA-dependent; sequestering of actin monomers" IPR001152; IPR016323; Thymosin beta-4 (T beta 4) [Cleaved into: Hematopoietic system regulatory peptide (Seraspenide)] Tmsb4x Ptmb4 Tmsb4 Mus musculus (Mouse) TR26279_c6_g1_i1 B2LT62 TLR2_CAPIB 5.00E-20 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Capra ibex (Ibex) TR26280_c2_g1_i1 Q5NVK7 SPOP_PONAB 5.00E-11 GO:0031463; GO:0016607; GO:0005634; GO:0043161; GO:0016567 Cul3-RING ubiquitin ligase complex; nuclear speck; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination IPR000210; IPR011333; IPR013069; IPR002083; IPR008974; Protein modification; protein ubiquitination. Speckle-type POZ protein SPOP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR26282_c0_g1_i1 O88327 CTNL1_MOUSE 9.00E-80 GO:0007266; GO:0015629; GO:0007155; GO:0005829; GO:0005886; GO:0005198 Rho protein signal transduction; actin cytoskeleton; cell adhesion; cytosol; plasma membrane; structural molecule activity IPR001033; IPR006077; Alpha-catulin (Alpha-catenin-related protein) (ACRP) (Catenin alpha-like protein 1) Ctnnal1 Catnal1 Mus musculus (Mouse) TR26282_c0_g1_i2 P90947 HMP1_CAEEL 5.00E-08 GO:0015629; GO:0051015; GO:0043296; GO:0007155; GO:0042074; GO:0005913; GO:0007016; GO:0010172; GO:0032956; GO:0032880; GO:0005198 actin cytoskeleton; actin filament binding; apical junction complex; cell adhesion; cell migration involved in gastrulation; cell-cell adherens junction; cytoskeletal anchoring at plasma membrane; embryonic body morphogenesis; regulation of actin cytoskeleton organization; regulation of protein localization; structural molecule activity IPR001033; IPR006077; Protein humpback-1 hmp-1 R13H4.4 Caenorhabditis elegans TR26283_c0_g1_i1 P41105 RL28_MOUSE 2.00E-42 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR002672; 60S ribosomal protein L28 Rpl28 Mus musculus (Mouse) TR26285_c0_g1_i1 C3XVM1 GATC_BRAFL 7.00E-46 GO:0005524; GO:0016874; GO:0005739; GO:0006450; GO:0006412 ATP binding; ligase activity; mitochondrion; regulation of translational fidelity; translation IPR003837; "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (Glu-AdT subunit C) (EC 6.3.5.-)" BRAFLDRAFT_270748 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR26291_c2_g1_i1 A8V0B3 NEURM_HIRME 8.00E-09 GO:0005576 extracellular region Neuromacin Hirudo medicinalis (Medicinal leech) TR26293_c0_g1_i1 Q0MQ88 NDUAD_PONPY 1.00E-19 GO:0008137; GO:0030262; GO:0097190; GO:0016021; GO:0005747; GO:0030308; GO:2001243; GO:0045892; GO:0017148; GO:0005654; GO:0072593 "NADH dehydrogenase (ubiquinone) activity; apoptotic nuclear changes; apoptotic signaling pathway; integral to membrane; mitochondrial respiratory chain complex I; negative regulation of cell growth; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of transcription, DNA-dependent; negative regulation of translation; nucleoplasm; reactive oxygen species metabolic process" IPR009346; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (Complex I-B16.6) (CI-B16.6) (NADH-ubiquinone oxidoreductase B16.6 subunit) NDUFA13 Pongo pygmaeus (Bornean orangutan) TR26301_c0_g1_i1 Q7Z0T3 TEMPT_APLCA 4.00E-24 GO:0005576 extracellular region Temptin Aplysia californica (California sea hare) TR26302_c0_g1_i1 Q91ZW8 C209D_MOUSE 1.00E-12 GO:0042742; GO:0006897; GO:0016021; GO:0005537; GO:0046872; GO:0050715 defense response to bacterium; endocytosis; integral to membrane; mannose binding; metal ion binding; positive regulation of cytokine secretion IPR001304; IPR016186; IPR018378; IPR016187; CD209 antigen-like protein D (DC-SIGN-related protein 3) (DC-SIGNR3) (CD antigen CD209) Cd209d Mus musculus (Mouse) TR26302_c0_g2_i1 Q8HYC0 CLC4M_PANTR 2.00E-17 GO:0006897; GO:0045087; GO:0016021; GO:0005537; GO:0046872 endocytosis; innate immune response; integral to membrane; mannose binding; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (CD antigen CD299) CLEC4M CD209L1 Pan troglodytes (Chimpanzee) TR26303_c0_g2_i1 O70421 FZD1_MOUSE 3.00E-24 GO:0004930; GO:0007199; GO:0030165; GO:0007223; GO:0042813; GO:0045177; GO:0035425; GO:0007409; GO:0007420; GO:0060070; GO:0044338; GO:0044339; GO:0009986; GO:0007267; GO:0005737; GO:0030855; GO:0008406; GO:0060022; GO:0016021; GO:0048286; GO:0003149; GO:0003150; GO:0030514; GO:0090090; GO:0035414; GO:0045892; GO:0032589; GO:0003151; GO:0090179; GO:0001934; GO:0051091; GO:0045893; GO:0006357; GO:0042493; GO:0001944 "G-protein coupled receptor activity; G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; PDZ domain binding; Wnt receptor signaling pathway, calcium modulating pathway; Wnt-activated receptor activity; apical part of cell; autocrine signaling; axonogenesis; brain development; canonical Wnt receptor signaling pathway; canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation; canonical Wnt receptor signaling pathway involved in osteoblast differentiation; cell surface; cell-cell signaling; cytoplasm; epithelial cell differentiation; gonad development; hard palate development; integral to membrane; lung alveolus development; membranous septum morphogenesis; muscular septum morphogenesis; negative regulation of BMP signaling pathway; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of catenin import into nucleus; negative regulation of transcription, DNA-dependent; neuron projection membrane; outflow tract morphogenesis; planar cell polarity pathway involved in neural tube closure; positive regulation of protein phosphorylation; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; response to drug; vasculature development" IPR000539; IPR015526; IPR020067; IPR026548; IPR017981; Frizzled-1 (Fz-1) (mFz1) Fzd1 Mus musculus (Mouse) TR26304_c0_g2_i1 Q24251 ATP5H_DROME 5.00E-18 GO:0015986; GO:0015078; GO:0005811; GO:0005875; GO:0000276; GO:0005739 "ATP synthesis coupled proton transport; hydrogen ion transmembrane transporter activity; lipid particle; microtubule associated complex; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); mitochondrion" IPR008689; "ATP synthase subunit d, mitochondrial (ATPase subunit d)" ATPsyn-d CG6030 Drosophila melanogaster (Fruit fly) TR26312_c0_g1_i1 Q9TTT7 CX6A1_RABIT 6.00E-13 GO:0004129; GO:0005751 cytochrome-c oxidase activity; mitochondrial respiratory chain complex IV IPR001349; IPR018507; "Cytochrome c oxidase subunit 6A1, mitochondrial (Cytochrome c oxidase polypeptide VIa-liver)" COX6A1 COXVIA2 Oryctolagus cuniculus (Rabbit) TR26315_c2_g1_i1 P09487 PPBT_BOVIN 9.00E-93 GO:0004035; GO:0031225; GO:0046872; GO:0005886; GO:0033280 alkaline phosphatase activity; anchored to membrane; metal ion binding; plasma membrane; response to vitamin D IPR017849; IPR001952; IPR018299; IPR017850; "Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)" ALPL Bos taurus (Bovine) TR26322_c0_g1_i1 Q5ZM20 RMI2_CHICK 4.00E-10 GO:0003677; GO:0006260; GO:0005737; GO:0005634 DNA binding; DNA replication; cytoplasm; nucleus RecQ-mediated genome instability protein 2 RMI2 RCJMB04_3g8 Gallus gallus (Chicken) TR26326_c0_g3_i1 Q8TDG4 HELQ_HUMAN 1.00E-117 GO:0005524; GO:0008026; GO:0003676; GO:0005730 ATP binding; ATP-dependent helicase activity; nucleic acid binding; nucleolus IPR011545; IPR014001; IPR001650; IPR027417; Helicase POLQ-like (EC 3.6.4.12) (Mus308-like helicase) (POLQ-like helicase) HELQ HEL308 Homo sapiens (Human) TR26327_c1_g2_i1 Q3U0Y2 ZMYNB_MOUSE 8.00E-06 GO:0016021 integral to membrane Uncharacterized protein ZMYM6NB Zmym6nb Gm12942 Mus musculus (Mouse) TR26328_c0_g1_i1 Q29611 CLN3_CANFA 7.00E-12 GO:0000139; GO:0005795; GO:0042987; GO:0015809; GO:0005901; GO:0005769; GO:0006681; GO:0001575; GO:0006678; GO:0030176; GO:0005770; GO:0007042; GO:0035752; GO:0005765; GO:0043066; GO:0043005; GO:0005634; GO:0006898; GO:0006684; GO:0008021; GO:0005802; GO:0007034; GO:0047496 Golgi membrane; Golgi stack; amyloid precursor protein catabolic process; arginine transport; caveola; early endosome; galactosylceramide metabolic process; globoside metabolic process; glucosylceramide metabolic process; integral to endoplasmic reticulum membrane; late endosome; lysosomal lumen acidification; lysosomal lumen pH elevation; lysosomal membrane; negative regulation of apoptotic process; neuron projection; nucleus; receptor-mediated endocytosis; sphingomyelin metabolic process; synaptic vesicle; trans-Golgi network; vacuolar transport; vesicle transport along microtubule IPR003492; IPR018460; IPR016196; Battenin (Protein CLN3) CLN3 Canis familiaris (Dog) (Canis lupus familiaris) TR26328_c2_g1_i1 Q54F25 CLN3_DICDI 6.00E-31 GO:0015809; GO:0031301; GO:0005765; GO:0051453; GO:0007034; GO:0005773; GO:0007033 arginine transport; integral to organelle membrane; lysosomal membrane; regulation of intracellular pH; vacuolar transport; vacuole; vacuole organization IPR003492; IPR016196; Battenin (Protein CLN3 homolog) cln3 DDB_G0291157 Dictyostelium discoideum (Slime mold) TR26328_c3_g1_i3 Q54F25 CLN3_DICDI 6.00E-08 GO:0015809; GO:0031301; GO:0005765; GO:0051453; GO:0007034; GO:0005773; GO:0007033 arginine transport; integral to organelle membrane; lysosomal membrane; regulation of intracellular pH; vacuolar transport; vacuole; vacuole organization IPR003492; IPR016196; Battenin (Protein CLN3 homolog) cln3 DDB_G0291157 Dictyostelium discoideum (Slime mold) TR26331_c0_g1_i1 Q3ZBM4 ITBP1_BOVIN 1.00E-15 GO:0005092; GO:0007219; GO:0032148; GO:0031214; GO:0002043; GO:0030154; GO:0007160; GO:0044344; GO:0035924; GO:0005856; GO:0005829; GO:0033622; GO:0005178; GO:0007229; GO:0030027; GO:0051451; GO:0070373; GO:0006933; GO:0090051; GO:0008285; GO:0010764; GO:0051895; GO:0032091; GO:0006469; GO:0090315; GO:1900025; GO:0005634; GO:0048471; GO:0005886; GO:0045747; GO:0051781; GO:0008284; GO:0010595; GO:0051894; GO:0051897; GO:0090314; GO:0051496; GO:0045944; GO:0019901; GO:0008565; GO:0043113; GO:0043088; GO:0050880; GO:0033628; GO:2001044; GO:0001726; GO:0006351; GO:0035148 "GDP-dissociation inhibitor activity; Notch signaling pathway; activation of protein kinase B activity; biomineral tissue development; blood vessel endothelial cell proliferation involved in sprouting angiogenesis; cell differentiation; cell-matrix adhesion; cellular response to fibroblast growth factor stimulus; cellular response to vascular endothelial growth factor stimulus; cytoskeleton; cytosol; integrin activation; integrin binding; integrin-mediated signaling pathway; lamellipodium; myoblast migration; negative regulation of ERK1 and ERK2 cascade; negative regulation of cell adhesion involved in substrate-bound cell migration; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell proliferation; negative regulation of fibroblast migration; negative regulation of focal adhesion assembly; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of protein targeting to membrane; negative regulation of substrate adhesion-dependent cell spreading; nucleus; perinuclear region of cytoplasm; plasma membrane; positive regulation of Notch signaling pathway; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of endothelial cell migration; positive regulation of focal adhesion assembly; positive regulation of protein kinase B signaling cascade; positive regulation of protein targeting to membrane; positive regulation of stress fiber assembly; positive regulation of transcription from RNA polymerase II promoter; protein kinase binding; protein transporter activity; receptor clustering; regulation of Cdc42 GTPase activity; regulation of blood vessel size; regulation of cell adhesion mediated by integrin; regulation of integrin-mediated signaling pathway; ruffle; transcription, DNA-dependent; tube formation" IPR019517; IPR011993; IPR006020; Integrin beta-1-binding protein 1 ITGB1BP1 Bos taurus (Bovine) TR26333_c0_g1_i1 O57592 RL7A_TAKRU 2.00E-130 GO:0005840; GO:0042254 ribosome; ribosome biogenesis IPR001921; IPR004038; IPR018492; IPR004037; 60S ribosomal protein L7a (Surfeit locus protein 3) rpl7a surf3 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR26339_c0_g1_i1 P08106 HSP70_CHICK 4.00E-82 GO:0005524; GO:0009986; GO:0005576; GO:0009408 Q8AYS8 ATP binding; cell surface; extracellular region; response to heat IPR018181; IPR013126; Heat shock 70 kDa protein (HSP70) Gallus gallus (Chicken) TR26339_c0_g1_i2 P86204 HSP72_MESAU 4.00E-22 GO:0005524; GO:0036128; GO:0006950 ATP binding; CatSper complex; response to stress IPR013126; Heat shock-related 70 kDa protein 2 (Fragments) HSPA2 Mesocricetus auratus (Golden hamster) TR26339_c0_g1_i3 P54652 HSP72_HUMAN 8.00E-126 GO:0005524; GO:0036128; GO:0009986; GO:0051861; GO:0001673; GO:0007140; GO:0007141; GO:0005739; GO:0031662; GO:0006986; GO:0007286; GO:0000795; GO:0070194; GO:0051082 Q9NZL4 ATP binding; CatSper complex; cell surface; glycolipid binding; male germ cell nucleus; male meiosis; male meiosis I; mitochondrion; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle; response to unfolded protein; spermatid development; synaptonemal complex; synaptonemal complex disassembly; unfolded protein binding IPR018181; IPR013126; Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) HSPA2 Homo sapiens (Human) TR26339_c0_g1_i4 P08106 HSP70_CHICK 3.00E-127 GO:0005524; GO:0009986; GO:0005576; GO:0009408 Q8AYS8 ATP binding; cell surface; extracellular region; response to heat IPR018181; IPR013126; Heat shock 70 kDa protein (HSP70) Gallus gallus (Chicken) TR26339_c0_g1_i5 Q91291 HSP70_PLEWA 9.00E-110 GO:0005524; GO:0006950 ATP binding; response to stress IPR018181; IPR013126; Heat shock 70 kDa protein (HSP70) HSP70 Pleurodeles waltl (Iberian ribbed newt) TR26342_c3_g1_i1 P18173 DHGL_DROME 2.00E-33 GO:0006066; GO:0008812; GO:0005576; GO:0050660; GO:0004344; GO:0006006; GO:0008364; GO:0046693 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding; glucose dehydrogenase activity; glucose metabolic process; pupal chitin-based cuticle development; sperm storage IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld CG1152 Drosophila melanogaster (Fruit fly) TR26343_c1_g1_i1 Q9UA35 S28A3_EPTST 9.00E-148 GO:0016021; GO:0005415 integral to membrane; nucleoside:sodium symporter activity IPR008276; IPR018270; IPR011657; IPR002668; Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT) SLC28A3 CNT3 Eptatretus stoutii (Pacific hagfish) TR26344_c0_g1_i1 Q80T79 CSMD3_MOUSE 1.00E-22 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 3 (CUB and sushi multiple domains protein 3) Csmd3 Kiaa1894 Mus musculus (Mouse) TR26346_c0_g1_i1 Q9VX32 RG190_DROME 3.00E-102 GO:0005525; GO:0005096; GO:0007415; GO:0005622; GO:0016319; GO:0045792; GO:0043547; GO:0050770; GO:0007264 GTP binding; GTPase activator activity; defasciculation of motor neuron axon; intracellular; mushroom body development; negative regulation of cell size; positive regulation of GTPase activity; regulation of axonogenesis; small GTPase mediated signal transduction IPR027417; IPR008936; IPR000198; IPR001806; Rho GTPase-activating protein 190 (Rho GTPase-activating protein of 190 kDa) RhoGAPp190 CG32555 Drosophila melanogaster (Fruit fly) TR26348_c1_g2_i1 P80436 TRS1_STRTI 1.00E-17 GO:0005524; GO:0017000; GO:0016874 ATP binding; antibiotic biosynthetic process; ligase activity IPR025110; IPR020845; IPR000873; Triostin synthetase I (TrsI) (EC 6.3.2.-) (AMP-binding ligase) (Quinoxaline-2-carboxylic acid-activating enzyme) trsA Streptomyces triostinicus TR26348_c1_g2_i3 Q8VCW8 ACSF2_MOUSE 3.00E-23 GO:0005524; GO:0006631; GO:0016874; GO:0005739 ATP binding; fatty acid metabolic process; ligase activity; mitochondrion IPR025110; IPR020845; IPR000873; "Acyl-CoA synthetase family member 2, mitochondrial (EC 6.2.1.-)" Acsf2 Mus musculus (Mouse) TR26349_c1_g1_i1 Q9UBY0 SL9A2_HUMAN 3.00E-21 GO:0016021; GO:0005886; GO:0008104; GO:0006885; GO:0015385 integral to membrane; plasma membrane; protein localization; regulation of pH; sodium:hydrogen antiporter activity IPR006153; IPR018422; IPR001953; IPR004709; Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2) SLC9A2 NHE2 Homo sapiens (Human) TR26351_c6_g1_i1 Q5ZJL7 DDB2_CHICK 5.00E-65 GO:0003677; GO:0006281; GO:0005634; GO:0051865; GO:0043234; GO:0000209; GO:0009411; GO:0004842 DNA binding; DNA repair; nucleus; protein autoubiquitination; protein complex; protein polyubiquitination; response to UV; ubiquitin-protein ligase activity IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. DNA damage-binding protein 2 (Damage-specific DNA-binding protein 2) DDB2 RCJMB04_17d21 Gallus gallus (Chicken) TR26352_c0_g1_i1 Q9VCA2 ORCT_DROME 2.00E-45 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR26352_c0_g1_i2 Q9WTN6 S22AL_MOUSE 3.00E-20 GO:0005524; GO:0015226; GO:0016021; GO:0031231 ATP binding; carnitine transmembrane transporter activity; integral to membrane; intrinsic to peroxisomal membrane IPR020846; IPR016196; IPR004749; IPR005828; IPR005829; Solute carrier family 22 member 21 (Organic cation/carnitine transporter 3) (Solute carrier family 22 member 9) Slc22a21 Octn3 Slc22a9 Mus musculus (Mouse) TR26352_c0_g1_i3 O23492 INT4_ARATH 2.00E-08 GO:0016021; GO:0005366; GO:0005886 integral to membrane; myo-inositol:hydrogen symporter activity; plasma membrane IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; Inositol transporter 4 (Myo-inositol-proton symporter INT4) (Protein INOSITOL TRANSPORTER 4) INT4 At4g16480 dl4265w FCAALL.375 Arabidopsis thaliana (Mouse-ear cress) TR26355_c0_g1_i1 Q2NKT2 SOSSC_BOVIN 3.00E-15 GO:0006281; GO:0070876; GO:0010212 DNA repair; SOSS complex; response to ionizing radiation SOSS complex subunit C (INTS3- and NABP-interacting protein) (Sensor of single-strand DNA complex subunit C) (Sensor of ssDNA subunit C) (SOSS-C) (Single-stranded DNA-binding protein-interacting protein 1) (SSB-interacting protein 1) INIP SSBIP1 Bos taurus (Bovine) TR26358_c2_g1_i1 Q9NY59 NSMA2_HUMAN 6.00E-24 GO:0000137; GO:0000139; GO:0007049; GO:0006687; GO:0046872; GO:0007275; GO:0030072; GO:0005886; GO:0006685; GO:0004767 Golgi cis cisterna; Golgi membrane; cell cycle; glycosphingolipid metabolic process; metal ion binding; multicellular organismal development; peptide hormone secretion; plasma membrane; sphingomyelin catabolic process; sphingomyelin phosphodiesterase activity IPR005135; Lipid metabolism; sphingolipid metabolism. Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) SMPD3 Homo sapiens (Human) TR26361_c1_g1_i1 Q54IT3 AOFA_DICDI 4.00E-17 GO:0016491 oxidoreductase activity IPR002937; IPR001613; Probable flavin-containing monoamine oxidase A (EC 1.4.3.4) maoA DDB_G0288541 Dictyostelium discoideum (Slime mold) TR26361_c3_g1_i2 Q6PLK3 AOFB_PIG 4.00E-40 GO:0016021; GO:0005741; GO:0016491 integral to membrane; mitochondrial outer membrane; oxidoreductase activity IPR002937; IPR001613; IPR016040; Amine oxidase [flavin-containing] B (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B) MAOB Sus scrofa (Pig) TR26374_c0_g2_i1 Q07DZ7 ASZ1_ORNAN 5.00E-48 GO:0043046; GO:0030154; GO:0031047; GO:0007140; GO:0007275; GO:0071546; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; cell differentiation; gene silencing by RNA; male meiosis; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002110; IPR020683; IPR001660; IPR013761; IPR011510; "Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)" ASZ1 GASZ Ornithorhynchus anatinus (Duckbill platypus) TR26375_c4_g1_i1 P0C0E9 ECFA_STRPY 5.00E-07 GO:0005524; GO:0006200; GO:0016887; GO:0005886; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; plasma membrane; transport IPR003593; IPR003439; IPR017871; IPR015856; IPR027417; Energy-coupling factor transporter ATP-binding protein EcfA (ECF transporter A component EcfA) (EC 3.6.3.-) ecfA cbiO stpA Streptococcus pyogenes TR26375_c4_g2_i1 Q13I12 CCMA_BURXL 1.00E-08 GO:0005524; GO:0006200; GO:0017004; GO:0015439; GO:0030288; GO:0005886 ATP binding; ATP catabolic process; cytochrome complex assembly; heme-transporting ATPase activity; outer membrane-bounded periplasmic space; plasma membrane IPR003593; IPR003439; IPR017871; IPR005895; IPR027417; Cytochrome c biogenesis ATP-binding export protein CcmA (EC 3.6.3.41) (Heme exporter protein A) ccmA Bxeno_C0349 Bxe_C0370 Burkholderia xenovorans (strain LB400) TR26375_c5_g1_i1 Q9BZC7 ABCA2_HUMAN 3.00E-102 GO:0005524; GO:0043190; GO:0042626; GO:0042632; GO:0016023; GO:0005768; GO:0010008; GO:0016021; GO:0006629; GO:0005765; GO:0005764; GO:0005815; GO:0032383; GO:0006357; GO:0042493; GO:0048545 "ATP binding; ATP-binding cassette (ABC) transporter complex; ATPase activity, coupled to transmembrane movement of substances; cholesterol homeostasis; cytoplasmic membrane-bounded vesicle; endosome; endosome membrane; integral to membrane; lipid metabolic process; lysosomal membrane; lysosome; microtubule organizing center; regulation of intracellular cholesterol transport; regulation of transcription from RNA polymerase II promoter; response to drug; response to steroid hormone stimulus" IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 2 (ATP-binding cassette transporter 2) (ATP-binding cassette 2) ABCA2 ABC2 KIAA1062 Homo sapiens (Human) TR26375_c7_g1_i1 Q99758 ABCA3_HUMAN 1.00E-43 GO:0005524; GO:0042626; GO:0097208; GO:0097233; GO:0016021; GO:0005886; GO:0042493 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; alveolar lamellar body; alveolar lamellar body membrane; integral to membrane; plasma membrane; response to drug" IPR003593; IPR026082; IPR003439; IPR017871; IPR026969; IPR027417; ATP-binding cassette sub-family A member 3 (ABC-C transporter) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) ABCA3 ABC3 Homo sapiens (Human) TR26375_c9_g1_i1 Q45460 OPUBA_BACSU 5.00E-08 GO:0005524; GO:0006200; GO:0016887; GO:0031460; GO:0016020 ATP binding; ATP catabolic process; ATPase activity; glycine betaine transport; membrane IPR003593; IPR003439; IPR017871; IPR013785; IPR000644; IPR005892; IPR027417; Choline transport ATP-binding protein OpuBA opuBA proV BSU33730 Bacillus subtilis (strain 168) TR26375_c9_g1_i2 O31427 SKFE_BACSU 3.00E-09 GO:0005524; GO:0006200; GO:0005886; GO:0015419 ATP binding; ATP catabolic process; plasma membrane; sulfate transmembrane-transporting ATPase activity IPR003593; IPR003439; IPR027417; SkfA peptide export ATP-binding protein SkfE (EC 3.6.3.25) skfE ybdA BSU01950 Bacillus subtilis (strain 168) TR26376_c0_g1_i1 Q9JI35 HRH3_CAVPO 2.00E-13 GO:0004969; GO:0016021; GO:0005886; GO:0001505 histamine receptor activity; integral to membrane; plasma membrane; regulation of neurotransmitter levels IPR000276; IPR017452; IPR003980; Histamine H3 receptor (H3R) (HH3R) HRH3 Cavia porcellus (Guinea pig) TR26378_c0_g1_i2 A8X481 EAT20_CAEBR 1.00E-06 GO:0016021 integral to membrane IPR000742; IPR013032; IPR003645; Abnormal pharyngeal pumping eat-20 eat-20 CBG07717 Caenorhabditis briggsae TR26381_c1_g1_i1 Q8IV35 WDR49_HUMAN 6.00E-13 IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 49 WDR49 Homo sapiens (Human) TR26384_c1_g1_i1 Q8R0J4 TM134_MOUSE 2.00E-07 GO:0016021 integral to membrane IPR008590; Transmembrane protein 134 Tmem134 Mus musculus (Mouse) TR26390_c0_g1_i2 Q8VHX6 FLNC_MOUSE 2.00E-19 GO:0030018; GO:0003779; GO:0015629; GO:0030029; GO:0048747; GO:0042383 Z disc; actin binding; actin cytoskeleton; actin filament-based process; muscle fiber development; sarcolemma IPR001589; IPR001715; IPR003961; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-C (FLN-C) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Flnc Abpl Fln2 Mus musculus (Mouse) TR26391_c1_g2_i1 Q9QYP1 LRP4_RAT 5.00E-23 GO:0016055; GO:0005509; GO:0030154; GO:0009953; GO:0042733; GO:0006897; GO:0001942; GO:0016021; GO:0001822; GO:0090090; GO:0030279; GO:0042475; GO:0005886; GO:0009954; GO:0043113; GO:0001932; GO:0051124 Wnt receptor signaling pathway; calcium ion binding; cell differentiation; dorsal/ventral pattern formation; embryonic digit morphogenesis; endocytosis; hair follicle development; integral to membrane; kidney development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of ossification; odontogenesis of dentin-containing tooth; plasma membrane; proximal/distal pattern formation; receptor clustering; regulation of protein phosphorylation; synaptic growth at neuromuscular junction IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) Lrp4 Megf7 Rattus norvegicus (Rat) TR26391_c1_g2_i4 O88572 LRP6_MOUSE 2.00E-33 GO:0044332; GO:0021874; GO:0090244; GO:0042813; GO:0090245; GO:0046849; GO:0060444; GO:0061310; GO:0061324; GO:0005901; GO:0042074; GO:0009986; GO:0071397; GO:0021587; GO:0021795; GO:0060026; GO:0015026; GO:0071936; GO:0031410; GO:0071542; GO:0005769; GO:0048596; GO:0042733; GO:0035115; GO:0035116; GO:0009880; GO:0060059; GO:0005783; GO:0035261; GO:0060325; GO:0021861; GO:0021943; GO:0001947; GO:0016021; GO:0019210; GO:0005041; GO:0060596; GO:0030901; GO:0030917; GO:0050680; GO:0045599; GO:2000151; GO:2000162; GO:2000168; GO:2000164; GO:2000166; GO:2000149; GO:0071901; GO:0034392; GO:0014029; GO:0001843; GO:0043025; GO:0042475; GO:0060021; GO:0003344; GO:2000055; GO:0043065; GO:0045780; GO:0090263; GO:0045787; GO:0002053; GO:0045778; GO:0051091; GO:0045944; GO:0036342; GO:0090009; GO:0043235; GO:0090118; GO:0060284; GO:0051593; GO:0048705; GO:0045202; GO:0007268; GO:0021794; GO:0019534; GO:0060535 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt receptor signaling pathway involved in forebrain neuroblast division; Wnt receptor signaling pathway involved in somitogenesis; Wnt-activated receptor activity; axis elongation involved in somitogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development; canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; caveola; cell migration involved in gastrulation; cell surface; cellular response to cholesterol; cerebellum morphogenesis; cerebral cortex cell migration; convergent extension; coreceptor activity; coreceptor activity involved in Wnt receptor signaling pathway; cytoplasmic vesicle; dopaminergic neuron differentiation; early endosome; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic pattern specification; embryonic retina morphogenesis in camera-type eye; endoplasmic reticulum; external genitalia morphogenesis; face morphogenesis; forebrain radial glial cell differentiation; formation of radial glial scaffolds; heart looping; integral to membrane; kinase inhibitor activity; low-density lipoprotein receptor activity; mammary placode formation; midbrain development; midbrain-hindbrain boundary development; negative regulation of epithelial cell proliferation; negative regulation of fat cell differentiation; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis; negative regulation of planar cell polarity pathway involved in neural tube closure; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest formation; neural tube closure; neuronal cell body; odontogenesis of dentin-containing tooth; palate development; pericardium morphogenesis; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell cycle; positive regulation of mesenchymal cell proliferation; positive regulation of ossification; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; post-anal tail morphogenesis; primitive streak formation; receptor complex; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport; regulation of cell development; response to folic acid; skeletal system morphogenesis; synapse; synaptic transmission; thalamus development; toxin transporter activity; trachea cartilage morphogenesis IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 6 (LRP-6) Lrp6 Mus musculus (Mouse) TR26395_c3_g1_i1 Q17QP1 ABHD8_BOVIN 3.00E-12 GO:0016787; GO:0008152 hydrolase activity; metabolic process IPR000073; IPR000639; Abhydrolase domain-containing protein 8 (EC 3.-.-.-) ABHD8 Bos taurus (Bovine) TR26398_c1_g1_i1 Q8N8K9 K1958_HUMAN 4.00E-10 IPR021893; Uncharacterized protein KIAA1958 KIAA1958 Homo sapiens (Human) TR26403_c0_g1_i1 Q5M9G0 DCTD_RAT 4.00E-53 GO:0004132; GO:0009165; GO:0008270 dCMP deaminase activity; nucleotide biosynthetic process; zinc ion binding IPR016192; IPR002125; IPR015517; IPR016193; IPR016473; Deoxycytidylate deaminase (EC 3.5.4.12) (dCMP deaminase) Dctd Rattus norvegicus (Rat) TR26409_c1_g1_i1 P20364 TBB1_DAUCA 1.00E-18 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta-1 chain (Beta-1-tubulin) (Fragment) TUBB1 Daucus carota (Carrot) TR26409_c1_g1_i2 P85108 TBB2A_RAT 6.00E-39 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0005886; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; plasma membrane; protein polymerization; structural constituent of cytoskeleton IPR013838; IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta-2A chain Tubb2a Rattus norvegicus (Rat) TR26411_c0_g1_i2 Q24157 BRN_DROME 5.00E-30 GO:0000139; GO:0005795; GO:0007219; GO:0046981; GO:0007298; GO:0005576; GO:0047915; GO:0007293; GO:0006688; GO:0008314; GO:0016021; GO:0042248; GO:0001744; GO:0007299; GO:0006486 "Golgi membrane; Golgi stack; Notch signaling pathway; beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity; border follicle cell migration; extracellular region; ganglioside galactosyltransferase activity; germarium-derived egg chamber formation; glycosphingolipid biosynthetic process; gurken receptor signaling pathway; integral to membrane; maintenance of polarity of follicular epithelium; optic lobe placode formation; ovarian follicle cell-cell adhesion; protein glycosylation" IPR002659; "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) TR26416_c3_g2_i1 O60303 K0556_HUMAN 5.00E-146 GO:0005634; GO:0005886 nucleus; plasma membrane IPR027859; IPR026704; Uncharacterized protein KIAA0556 KIAA0556 Homo sapiens (Human) TR26420_c3_g1_i1 B1AVY7 KI16B_MOUSE 7.00E-32 GO:0005524; GO:0006895; GO:0005769; GO:0031901; GO:0045022; GO:0007492; GO:0007173; GO:0008543; GO:0001704; GO:0005871; GO:0005874; GO:0007018; GO:0005547; GO:0043325; GO:0080025; GO:0032266; GO:0008574; GO:0032801; GO:0001919 "ATP binding; Golgi to endosome transport; early endosome; early endosome membrane; early endosome to late endosome transport; endoderm development; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; formation of primary germ layer; kinesin complex; microtubule; microtubule-based movement; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding; plus-end-directed microtubule motor activity; receptor catabolic process; regulation of receptor recycling" IPR000253; IPR027640; IPR019821; IPR001752; IPR027417; IPR001683; IPR008984; Kinesin-like protein KIF16B Kif16b Kiaa1590 Mus musculus (Mouse) TR26421_c1_g1_i1 O75581 LRP6_HUMAN 3.00E-103 GO:0044332; GO:0021874; GO:0090244; GO:0042813; GO:0034185; GO:0090245; GO:0060349; GO:0046849; GO:0060444; GO:0061310; GO:0044335; GO:0061324; GO:0044340; GO:0042074; GO:0009986; GO:0071397; GO:0021587; GO:0021795; GO:0021987; GO:0060026; GO:0071936; GO:0031410; GO:0071542; GO:0005769; GO:0048596; GO:0042733; GO:0035115; GO:0035116; GO:0030326; GO:0009880; GO:0060059; GO:0005783; GO:0035261; GO:0060325; GO:0021861; GO:0021943; GO:0001947; GO:0016021; GO:0019210; GO:0005041; GO:0060596; GO:0030901; GO:0030917; GO:0050680; GO:0045599; GO:2000151; GO:2000162; GO:2000168; GO:2000164; GO:2000166; GO:2000149; GO:0071901; GO:0034392; GO:0014029; GO:0001843; GO:0043025; GO:0042475; GO:0060021; GO:0003344; GO:0005886; GO:2000055; GO:0043065; GO:0045780; GO:0090263; GO:0045787; GO:0002053; GO:0045778; GO:0051091; GO:0045944; GO:0036342; GO:0090009; GO:0043235; GO:0090118; GO:0060284; GO:0045598; GO:0030278; GO:0051593; GO:0045202; GO:0007268; GO:0021794; GO:0019534; GO:0060535 Q9Y4X0; Q9H6X2; O70239; Q03135; P98082; P49840; P49841; Q5S007; Q9ERE8 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt receptor signaling pathway involved in forebrain neuroblast division; Wnt receptor signaling pathway involved in somitogenesis; Wnt-activated receptor activity; apolipoprotein binding; axis elongation involved in somitogenesis; bone morphogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development; canonical Wnt receptor signaling pathway involved in neural crest cell differentiation; canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; canonical Wnt receptor signaling pathway involved in regulation of cell proliferation; cell migration involved in gastrulation; cell surface; cellular response to cholesterol; cerebellum morphogenesis; cerebral cortex cell migration; cerebral cortex development; convergent extension; coreceptor activity involved in Wnt receptor signaling pathway; cytoplasmic vesicle; dopaminergic neuron differentiation; early endosome; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; embryonic pattern specification; embryonic retina morphogenesis in camera-type eye; endoplasmic reticulum; external genitalia morphogenesis; face morphogenesis; forebrain radial glial cell differentiation; formation of radial glial scaffolds; heart looping; integral to membrane; kinase inhibitor activity; low-density lipoprotein receptor activity; mammary placode formation; midbrain development; midbrain-hindbrain boundary development; negative regulation of epithelial cell proliferation; negative regulation of fat cell differentiation; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis; negative regulation of planar cell polarity pathway involved in neural tube closure; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest formation; neural tube closure; neuronal cell body; odontogenesis of dentin-containing tooth; palate development; pericardium morphogenesis; plasma membrane; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell cycle; positive regulation of mesenchymal cell proliferation; positive regulation of ossification; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; post-anal tail morphogenesis; primitive streak formation; receptor complex; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport; regulation of cell development; regulation of fat cell differentiation; regulation of ossification; response to folic acid; synapse; synaptic transmission; thalamus development; toxin transporter activity; trachea cartilage morphogenesis IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 6 (LRP-6) LRP6 Homo sapiens (Human) TR26422_c0_g2_i1 Q7M3Y3 TNNI_CHLNI 7.00E-40 GO:0046872; GO:0005861 metal ion binding; troponin complex IPR001978; Troponin I (TnI) Chlamys nipponensis akazara (Akazara scallop) (Japanese scallop) TR26425_c1_g1_i1 O02073 TBX18_CAEEL 1.00E-08 GO:0003677; GO:0042464; GO:0005634; GO:0045944; GO:0003700; GO:0007530; GO:0006351 "DNA binding; dosage compensation by hypoactivation of X chromosome; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sex determination; transcription, DNA-dependent" IPR008967; IPR001699; IPR018186; T-box transcription factor 18 (Signal element on autosome protein 1) sea-1 tbx-18 F19B10.9 Caenorhabditis elegans TR26425_c2_g1_i1 Q9IAK8 TBX5A_DANRE 1.00E-65 GO:0015629; GO:0003294; GO:0003190; GO:0055007; GO:0035118; GO:0001947; GO:0060174; GO:0005634; GO:0003344; GO:0045893; GO:0003342; GO:0043565; GO:0003700; GO:0006351 "actin cytoskeleton; atrial ventricular junction remodeling; atrioventricular valve formation; cardiac muscle cell differentiation; embryonic pectoral fin morphogenesis; heart looping; limb bud formation; nucleus; pericardium morphogenesis; positive regulation of transcription, DNA-dependent; proepicardium development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008967; IPR001699; IPR018186; T-box transcription factor TBX5-A (zftbx5a) (T-box protein 5) (zTbx5) tbx5a heartstrings hst tbx5 tbx5.1 si:ch211-245e21.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR26425_c2_g1_i2 Q7ZTU9 TBX2_DANRE 3.00E-75 GO:0003677; GO:0048318; GO:0003205; GO:0007155; GO:0042074; GO:0008283; GO:0021538; GO:0001947; GO:0030903; GO:0005634; GO:0043704; GO:0008016; GO:0046549; GO:0046548; GO:0003700; GO:0006351 "DNA binding; axial mesoderm development; cardiac chamber development; cell adhesion; cell migration involved in gastrulation; cell proliferation; epithalamus development; heart looping; notochord development; nucleus; photoreceptor cell fate specification; regulation of heart contraction; retinal cone cell development; retinal rod cell development; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008967; IPR022582; IPR002070; IPR001699; IPR018186; T-box transcription factor TBX2b (T-box protein 2b) tbx2b tbx-c Danio rerio (Zebrafish) (Brachydanio rerio) TR26426_c0_g1_i1 Q10655 ELT2_CAEEL 4.00E-20 GO:0003705; GO:0000977; GO:0007586; GO:0003690; GO:0007492; GO:0002119; GO:0005634; GO:0045944; GO:0030856; GO:0008270 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; RNA polymerase II regulatory region sequence-specific DNA binding; digestion; double-stranded DNA binding; endoderm development; nematode larval development; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of epithelial cell differentiation; zinc ion binding IPR000679; IPR013088; Transcription factor elt-2 elt-2 C33D3.1 Caenorhabditis elegans TR26426_c0_g1_i2 Q91677 GATA4_XENLA 1.00E-51 GO:0048738; GO:0005634; GO:0045944; GO:0043565; GO:0003700; GO:0044212; GO:0006351; GO:0008270 "cardiac muscle tissue development; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding; transcription, DNA-dependent; zinc ion binding" IPR008013; IPR016375; IPR000679; IPR013088; Transcription factor GATA-4 (GATA-binding factor 4) (xGATA-4) gata4 Xenopus laevis (African clawed frog) TR26428_c5_g1_i1 Q9Y238 DLEC1_HUMAN 1.00E-20 GO:0005737; GO:0008285 cytoplasm; negative regulation of cell proliferation Deleted in lung and esophageal cancer protein 1 (Deleted in lung cancer protein 1) (DLC-1) DLEC1 DLC1 Homo sapiens (Human) TR26430_c1_g3_i1 Q8N5C6 SRBD1_HUMAN 5.00E-26 GO:0003723; GO:0016788; GO:0006139 "RNA binding; hydrolase activity, acting on ester bonds; nucleobase-containing compound metabolic process" IPR012340; IPR003029; IPR022967; IPR012337; IPR010994; IPR023323; IPR023319; IPR018974; IPR023097; IPR006641; S1 RNA-binding domain-containing protein 1 SRBD1 Homo sapiens (Human) TR26431_c0_g1_i1 Q7ZTM9 EIF3D_XENLA 2.00E-128 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0006446; GO:0003743; GO:0006413 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; regulation of translational initiation; translation initiation factor activity; translational initiation IPR007783; Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) eif3d eif3s7 Xenopus laevis (African clawed frog) TR26434_c0_g1_i1 P81600 ADHH_GADMO 0 GO:0051903; GO:0004022; GO:0005737; GO:0006069; GO:0008270 S-(hydroxymethyl)glutathione dehydrogenase activity; alcohol dehydrogenase (NAD) activity; cytoplasm; ethanol oxidation; zinc ion binding IPR014183; IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; Alcohol dehydrogenase class-3 chain H (EC 1.1.1.1) (Alcohol dehydrogenase class-III chain H) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) Gadus morhua (Atlantic cod) TR26435_c1_g1_i1 Q7SZF1 CE022_DANRE 3.00E-06 IPR024131; UPF0489 protein C5orf22 homolog zgc:56556 Danio rerio (Zebrafish) (Brachydanio rerio) TR26436_c0_g1_i1 Q460N5 PAR14_HUMAN 1.00E-12 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR26436_c1_g1_i1 Q8CFF0 PAR11_MOUSE 3.00E-09 GO:0003950 NAD+ ADP-ribosyltransferase activity IPR012317; IPR004170; Poly [ADP-ribose] polymerase 11 (PARP-11) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 11) (ARTD11) Parp11 Mus musculus (Mouse) TR26437_c0_g1_i1 Q92625 ANS1A_HUMAN 8.00E-16 GO:0005737; GO:0048013; GO:0043005; GO:0016322; GO:0005634; GO:0006929 P00533; P04626 cytoplasm; ephrin receptor signaling pathway; neuron projection; neuron remodeling; nucleus; substrate-dependent cell migration IPR002110; IPR020683; IPR011993; IPR006020; IPR001660; IPR013761; IPR021129; Ankyrin repeat and SAM domain-containing protein 1A (Odin) ANKS1A ANKS1 KIAA0229 ODIN Homo sapiens (Human) TR26438_c0_g1_i1 Q9WYX8 Y508_THEMA 7.00E-11 GO:0005524; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0009378 ATP binding; DNA binding; DNA recombination; DNA repair; DNA replication; four-way junction helicase activity IPR003593; IPR008824; IPR008921; IPR002589; IPR021886; IPR027417; Uncharacterized protein TM_0508 TM_0508 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR26443_c2_g1_i1 Q5T5N4 CF118_HUMAN 3.00E-12 Uncharacterized protein C6orf118 C6orf118 Homo sapiens (Human) TR26445_c1_g1_i1 Q9SEE4 PIRL_SOLLC 6.00E-64 GO:0005634 nucleus IPR012093; IPR008778; IPR003829; IPR014710; IPR011051; Pirin-like protein Solanum lycopersicum (Tomato) (Lycopersicon esculentum) TR26449_c1_g1_i1 P83425 HIP_MYTED 2.00E-08 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR26449_c1_g1_i6 Q9ES30 C1QT3_MOUSE 4.00E-06 GO:0005581; GO:0005615; GO:0042593; GO:0042802; GO:0045721; GO:0070374; GO:0070165; GO:0050715; GO:0051897; GO:0051259 collagen; extracellular space; glucose homeostasis; identical protein binding; negative regulation of gluconeogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of adiponectin secretion; positive regulation of cytokine secretion; positive regulation of protein kinase B signaling cascade; protein oligomerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1qtnf3 Cors26 Ctrp3 Mus musculus (Mouse) TR26449_c1_g2_i1 A6H6E2 MMRN2_MOUSE 5.00E-06 GO:0001525; GO:0005604; GO:0005615; GO:0090051; GO:0030948 angiogenesis; basement membrane; extracellular space; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of vascular endothelial growth factor receptor signaling pathway IPR001073; IPR011489; IPR008983; Multimerin-2 Mmrn2 Mus musculus (Mouse) TR26450_c0_g1_i1 P02720 PPCT_BOVIN 3.00E-78 GO:0005737; GO:0031210; GO:0008525 cytoplasm; phosphatidylcholine binding; phosphatidylcholine transporter activity IPR023393; IPR002913; Phosphatidylcholine transfer protein (PC-TP) (START domain-containing protein 2) (StARD2) (StAR-related lipid transfer protein 2) PCTP STARD2 Bos taurus (Bovine) TR26452_c1_g1_i1 Q9UJU3 ZF112_HUMAN 2.00E-70 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 112 (Zfp-112) (Zinc finger protein 228) ZNF112 ZFP112 ZNF228 Homo sapiens (Human) TR26452_c1_g2_i1 P17022 ZNF18_HUMAN 1.00E-33 GO:0003677; GO:0046872; GO:0005634; GO:0000981 DNA binding; metal ion binding; nucleus; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR001909; IPR008916; IPR003309; IPR027764; IPR007087; IPR015880; IPR013087; Zinc finger protein 18 (Heart development-specific gene 1 protein) (Zinc finger protein 535) (Zinc finger protein KOX11) (Zinc finger protein with KRAB and SCAN domains 6) ZNF18 HDSG1 KOX11 ZKSCAN6 ZNF535 Homo sapiens (Human) TR26461_c0_g1_i1 Q2VLG6 C163A_CANFA 8.00E-14 GO:0006953; GO:0005576; GO:0016021; GO:0005886; GO:0005044 acute-phase response; extracellular region; integral to membrane; plasma membrane; scavenger receptor activity IPR001190; IPR017448; Scavenger receptor cysteine-rich type 1 protein M130 (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)] CD163 M130 Canis familiaris (Dog) (Canis lupus familiaris) TR26461_c1_g1_i1 O08762 NETR_MOUSE 1.00E-17 GO:0031410; GO:0030425; GO:0006887; GO:0005576; GO:0005886; GO:0006508; GO:0005044; GO:0004252; GO:0043083; GO:0043195; GO:0031638 cytoplasmic vesicle; dendrite; exocytosis; extracellular region; plasma membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity; synaptic cleft; terminal bouton; zymogen activation IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR001190; IPR017448; IPR009003; Neurotrypsin (EC 3.4.21.-) (Brain-specific serine protease 3) (BSSP-3) (Motopsin) (Serine protease 12) Prss12 Bssp3 Mus musculus (Mouse) TR26461_c2_g1_i1 Q86UP6 CUZD1_HUMAN 9.00E-14 GO:0007049; GO:0051301; GO:0008283; GO:0016021; GO:0006931; GO:0030658; GO:0032023; GO:0042589 "cell cycle; cell division; cell proliferation; integral to membrane; substrate-dependent cell migration, cell attachment to substrate; transport vesicle membrane; trypsinogen activation; zymogen granule membrane" IPR000859; IPR001507; CUB and zona pellucida-like domain-containing protein 1 (CUB and ZP domain-containing protein 1) (Transmembrane protein UO-44) CUZD1 UNQ224/PRO257 Homo sapiens (Human) TR26461_c3_g1_i1 P30204 MSRE_MOUSE 1.00E-11 GO:0030301; GO:0005581; GO:0016021; GO:0042953; GO:0034362; GO:0030169; GO:0034381; GO:0005886; GO:0010886; GO:0010744; GO:0005044 cholesterol transport; collagen; integral to membrane; lipoprotein transport; low-density lipoprotein particle; low-density lipoprotein particle binding; plasma lipoprotein particle clearance; plasma membrane; positive regulation of cholesterol storage; positive regulation of macrophage derived foam cell differentiation; scavenger receptor activity IPR008160; IPR003543; IPR001190; IPR017448; Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor type A) (SR-A) (CD antigen CD204) Msr1 Scvr Mus musculus (Mouse) TR26463_c2_g1_i1 P38127 RIM2_YEAST 1.00E-08 GO:0016021; GO:0000002; GO:0005743; GO:0005739; GO:0015218 integral to membrane; mitochondrial genome maintenance; mitochondrial inner membrane; mitochondrion; pyrimidine nucleotide transmembrane transporter activity IPR002067; IPR018108; IPR023395; Mitochondrial carrier protein RIM2 RIM2 YBR192W YBR1402 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR26463_c2_g1_i2 Q05AQ3 S2542_XENTR 2.00E-87 GO:0015217; GO:0080122; GO:0005347; GO:0043262; GO:0015228; GO:0016021; GO:0005743; GO:0005739 ADP transmembrane transporter activity; AMP transmembrane transporter activity; ATP transmembrane transporter activity; adenosine-diphosphatase activity; coenzyme A transmembrane transporter activity; integral to membrane; mitochondrial inner membrane; mitochondrion IPR002167; IPR002067; IPR018108; IPR023395; Mitochondrial coenzyme A transporter SLC25A42 (Solute carrier family 25 member 42) slc25a42 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR26469_c0_g1_i1 Q4VBI7 STX18_DANRE 1.00E-102 GO:0005789; GO:0016021; GO:0006886; GO:0016192 endoplasmic reticulum membrane; integral to membrane; intracellular protein transport; vesicle-mediated transport IPR019529; IPR006012; Syntaxin-18 stx18 zgc:112326 Danio rerio (Zebrafish) (Brachydanio rerio) TR26471_c1_g1_i2 P52742 ZN135_HUMAN 5.00E-12 GO:0003677; GO:0007010; GO:0046872; GO:0005634; GO:0022604; GO:0003700; GO:0006351 "DNA binding; cytoskeleton organization; metal ion binding; nucleus; regulation of cell morphogenesis; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 135 (Zinc finger protein 61) (Zinc finger protein 78-like 1) ZNF135 ZNF61 ZNF78L1 Homo sapiens (Human) TR26471_c1_g2_i1 B4DU55 ZN879_HUMAN 6.00E-14 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 879 ZNF879 Homo sapiens (Human) TR26472_c1_g1_i1 B7ZRM8 EVI1B_XENLA 8.00E-13 GO:0003677; GO:0046872; GO:0016607; GO:0039013; GO:0039022; GO:0072196; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nuclear speck; pronephric distal tubule morphogenesis; pronephric duct development; proximal/distal pattern formation involved in pronephric nephron development; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; MDS1 and EVI1 complex locus protein EVI1-B (Ecotropic virus integration site 1 protein homolog-B) mecom-b evi1-b Xenopus laevis (African clawed frog) TR26472_c5_g1_i1 Q3UH06 RREB1_MOUSE 1.00E-23 GO:0003677; GO:0046872; GO:0045892; GO:0016607; GO:0003700; GO:0006351 "DNA binding; metal ion binding; negative regulation of transcription, DNA-dependent; nuclear speck; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Ras-responsive element-binding protein 1 (RREB-1) (RAS-responsive zinc finger transcription factor RREB) Rreb1 Mus musculus (Mouse) TR26478_c0_g1_i2 Q9UM22 EPDR1_HUMAN 1.00E-12 GO:0005509; GO:0007160; GO:0005576; GO:0005764 calcium ion binding; cell-matrix adhesion; extracellular region; lysosome IPR001299; IPR018224; Mammalian ependymin-related protein 1 (MERP-1) (Upregulated in colorectal cancer gene 1 protein) EPDR1 MERP1 UCC1 Homo sapiens (Human) TR26481_c3_g1_i1 Q96JK2 DCAF5_HUMAN 2.00E-96 GO:0080008; GO:0005739; GO:0016567 Cul4-RING ubiquitin ligase complex; mitochondrion; protein ubiquitination IPR015943; IPR001680; IPR017986; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) DCAF5 BCRG2 KIAA1824 WDR22 Homo sapiens (Human) TR26485_c0_g1_i1 Q9D3D9 ATPD_MOUSE 7.00E-47 GO:0006200; GO:0015986; GO:0005753; GO:0046933; GO:0045261; GO:0046961 "ATP catabolic process; ATP synthesis coupled proton transport; mitochondrial proton-transporting ATP synthase complex; proton-transporting ATP synthase activity, rotational mechanism; proton-transporting ATP synthase complex, catalytic core F(1); proton-transporting ATPase activity, rotational mechanism" IPR001469; IPR020546; IPR020547; "ATP synthase subunit delta, mitochondrial (F-ATPase delta subunit)" Atp5d Mus musculus (Mouse) TR26488_c0_g1_i1 Q9Z315 SNUT1_MOUSE 2.00E-27 GO:0015030; GO:0005794; GO:0008380; GO:0071013; GO:0006397; GO:0045585 Cajal body; Golgi apparatus; RNA splicing; catalytic step 2 spliceosome; mRNA processing; positive regulation of cytotoxic T cell differentiation IPR005011; U4/U6.U5 tri-snRNP-associated protein 1 (Hypoxia-associated factor) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (mSART-1) Sart1 Haf Mus musculus (Mouse) TR26488_c0_g2_i1 O43290 SNUT1_HUMAN 1.00E-52 GO:0015030; GO:0005794; GO:0071013; GO:0007050; GO:0005829; GO:0097193; GO:0045585; GO:0000387 Q13573; P63165; P55854 Cajal body; Golgi apparatus; catalytic step 2 spliceosome; cell cycle arrest; cytosol; intrinsic apoptotic signaling pathway; positive regulation of cytotoxic T cell differentiation; spliceosomal snRNP assembly IPR005011; U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) SART1 Homo sapiens (Human) TR26489_c0_g1_i1 P79334 PYGM_BOVIN 0 GO:0005977; GO:0008184; GO:0000166; GO:0030170 glycogen metabolic process; glycogen phosphorylase activity; nucleotide binding; pyridoxal phosphate binding IPR011833; IPR000811; "Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase)" PYGM Bos taurus (Bovine) TR2649_c0_g1_i1 Q9H8V3 ECT2_HUMAN 3.00E-18 GO:0005096; GO:0005089; GO:0032863; GO:0032147; GO:0097190; GO:0000902; GO:0071277; GO:0070301; GO:0071479; GO:0097149; GO:0032154; GO:0000910; GO:0005829; GO:0030496; GO:0048011; GO:0005634; GO:0005543; GO:0043089; GO:0043123; GO:0043065; GO:0032467; GO:0045666; GO:0042307; GO:0042803; GO:0051260; GO:0015031; GO:0051988; GO:0004871; GO:0007264; GO:0005923; GO:0070830 P16333 GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; activation of Rac GTPase activity; activation of protein kinase activity; apoptotic signaling pathway; cell morphogenesis; cellular response to calcium ion; cellular response to hydrogen peroxide; cellular response to ionizing radiation; centralspindlin complex; cleavage furrow; cytokinesis; cytosol; midbody; neurotrophin TRK receptor signaling pathway; nucleus; phospholipid binding; positive regulation of Cdc42 GTPase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptotic process; positive regulation of cytokinesis; positive regulation of neuron differentiation; positive regulation of protein import into nucleus; protein homodimerization activity; protein homooligomerization; protein transport; regulation of attachment of spindle microtubules to kinetochore; signal transducer activity; small GTPase mediated signal transduction; tight junction; tight junction assembly IPR001357; IPR000219; IPR026817; IPR001331; IPR011993; IPR001849; Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) ECT2 Homo sapiens (Human) TR26495_c0_g1_i1 P31249 HXD3_HUMAN 9.00E-28 GO:0007219; GO:0009952; GO:0051216; GO:0007160; GO:0048704; GO:0021615; GO:0005634; GO:0010628; GO:0045666; GO:0043565; GO:0003700; GO:0030878; GO:0006351 P09022 "Notch signaling pathway; anterior/posterior pattern specification; cartilage development; cell-matrix adhesion; embryonic skeletal system morphogenesis; glossopharyngeal nerve morphogenesis; nucleus; positive regulation of gene expression; positive regulation of neuron differentiation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; thyroid gland development; transcription, DNA-dependent" IPR025281; IPR001827; IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein Hox-D3 (Homeobox protein Hox-4A) HOXD3 HOX1D HOX4A Homo sapiens (Human) TR26495_c0_g2_i1 P70118 PDX1_MESAU 1.00E-35 GO:0005829; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "cytosol; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017995; IPR017970; IPR001356; IPR020479; IPR009057; Pancreas/duodenum homeobox protein 1 (Homeodomain protein PDX1) (Insulin promoter factor 1) (IPF-1) PDX1 IPF1 Mesocricetus auratus (Golden hamster) TR26496_c1_g1_i2 Q3USW5 FXRD2_MOUSE 0 GO:0030433; GO:0005788; GO:0050660; GO:0016491 ER-associated protein catabolic process; endoplasmic reticulum lumen; flavin adenine dinucleotide binding; oxidoreductase activity FAD-dependent oxidoreductase domain-containing protein 2 Foxred2 D15Bwg0759e Mus musculus (Mouse) TR26497_c0_g1_i2 Q32L97 VAMP4_BOVIN 9.00E-27 GO:0005794; GO:0016021; GO:0016192 Golgi apparatus; integral to membrane; vesicle-mediated transport IPR001388; IPR016444; Vesicle-associated membrane protein 4 (VAMP-4) VAMP4 Bos taurus (Bovine) TR26498_c8_g1_i1 Q9UGM6 SYWM_HUMAN 2.00E-62 GO:0005524; GO:0005759; GO:0006418; GO:0004830; GO:0006436; GO:0001570 ATP binding; mitochondrial matrix; tRNA aminoacylation for protein translation; tryptophan-tRNA ligase activity; tryptophanyl-tRNA aminoacylation; vasculogenesis IPR001412; IPR002305; IPR014729; IPR002306; IPR024109; "Tryptophan--tRNA ligase, mitochondrial (EC 6.1.1.2) ((Mt)TrpRS) (Tryptophanyl-tRNA synthetase) (TrpRS)" WARS2 Homo sapiens (Human) TR26498_c8_g1_i2 P00953 SYW_GEOSE 6.00E-44 GO:0005524; GO:0005737; GO:0004830; GO:0006436 ATP binding; cytoplasm; tryptophan-tRNA ligase activity; tryptophanyl-tRNA aminoacylation IPR001412; IPR002305; IPR014729; IPR002306; IPR024109; Tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) trpS Geobacillus stearothermophilus (Bacillus stearothermophilus) TR26501_c1_g1_i2 A2AAJ9 OBSCN_MOUSE 1.00E-06 GO:0005524; GO:0031430; GO:0005089; GO:0030154; GO:0007275; GO:0018108; GO:0005543; GO:0004674; GO:0004713; GO:0035023 ATP binding; M band; Rho guanyl-nucleotide exchange factor activity; cell differentiation; multicellular organismal development; peptidyl-tyrosine phosphorylation; phospholipid binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of Rho protein signal transduction IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000048; IPR011009; IPR011993; IPR001849; IPR000719; IPR017441; IPR002290; IPR008271; IPR001452; IPR008266; Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Obscn Gm878 Mus musculus (Mouse) TR26501_c1_g1_i4 A2ASS6 TITIN_MOUSE 1.00E-07 GO:0005524; GO:0031430; GO:0030018; GO:0007512; GO:0055003; GO:0043056; GO:0003007; GO:0001701; GO:0046872; GO:0006936; GO:0005859; GO:0005634; GO:0018108; GO:0004674; GO:0004713; GO:1901897; GO:0045214; GO:0001756; GO:0005200 ATP binding; M band; Z disc; adult heart development; cardiac myofibril assembly; forward locomotion; heart morphogenesis; in utero embryonic development; metal ion binding; muscle contraction; muscle myosin complex; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of relaxation of cardiac muscle; sarcomere organization; somitogenesis; structural constituent of cytoskeleton IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) TR26502_c2_g1_i1 P02746 C1QB_HUMAN 9.00E-06 GO:0005581; GO:0006958; GO:0005602; GO:0045087; GO:0048839 P02745 "collagen; complement activation, classical pathway; complement component C1 complex; innate immune response; inner ear development" IPR001073; IPR008160; IPR008983; Complement C1q subcomponent subunit B C1QB Homo sapiens (Human) TR26502_c2_g2_i1 Q9H8L6 MMRN2_HUMAN 2.00E-06 GO:0001525; GO:0005604; GO:0005615; GO:0090051; GO:0030948 angiogenesis; basement membrane; extracellular space; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of vascular endothelial growth factor receptor signaling pathway IPR001073; IPR011489; IPR008983; Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit) MMRN2 EMILIN3 Homo sapiens (Human) TR26507_c3_g1_i2 Q19417 YSNK_CAEEL 5.00E-08 GO:0016021 integral to membrane IPR008166; UPF0392 protein F13G3.3 F13G3.3 Caenorhabditis elegans TR26512_c0_g2_i1 Q54SZ9 Y2107_DICDI 3.00E-06 GO:0006869 lipid transport IPR014756; IPR003172; Putative phosphatidylglycerol/phosphatidylinositol transfer protein DDB_G0282107 DDB_G0282107 Dictyostelium discoideum (Slime mold) TR26520_c3_g1_i1 Q15043 S39AE_HUMAN 4.00E-59 GO:0005794; GO:0006882; GO:0005783; GO:0015093; GO:0005887; GO:0030027; GO:0071578; GO:0005385 Golgi apparatus; cellular zinc ion homeostasis; endoplasmic reticulum; ferrous iron transmembrane transporter activity; integral to plasma membrane; lamellipodium; zinc ion transmembrane import; zinc ion transmembrane transporter activity IPR003689; Zinc transporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14) SLC39A14 KIAA0062 ZIP14 Homo sapiens (Human) TR26523_c8_g1_i1 Q9D5Y0 CG031_MOUSE 2.00E-13 IPR027886; Uncharacterized protein C7orf31 homolog (Protein TISP74) Mus musculus (Mouse) TR26529_c0_g1_i1 Q5EA19 ARL15_BOVIN 4.00E-53 GO:0005525; GO:0005622; GO:0007264 GTP binding; intracellular; small GTPase mediated signal transduction IPR027417; IPR024156; IPR006689; ADP-ribosylation factor-like protein 15 ARL15 Bos taurus (Bovine) TR26529_c0_g1_i2 O45379 ARL3_CAEEL 5.00E-25 GO:0005525; GO:0005794; GO:0015031; GO:0007264; GO:0016192 Q18268; Q10658 GTP binding; Golgi apparatus; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 3 arl-3 F19H8.3 Caenorhabditis elegans TR2653_c0_g1_i1 Q9R0W5 ASIC5_RAT 8.00E-11 GO:0016021; GO:0015280; GO:0005886 integral to membrane; ligand-gated sodium channel activity; plasma membrane IPR001873; Acid-sensing ion channel 5 (ASIC5) (Amiloride-sensitive cation channel 5) (Brain-liver-intestine amiloride-sensitive Na(+) channel) (BLINaC) Asic5 Accn5 Blinac Rattus norvegicus (Rat) TR26533_c0_g1_i1 F6XZJ7 SAM15_MOUSE 6.00E-20 IPR001660; IPR013761; IPR021129; Sterile alpha motif domain-containing protein 15 (SAM domain-containing protein 15) Samd15 Gm263 Mus musculus (Mouse) TR26534_c0_g1_i1 Q02375 NDUS4_BOVIN 3.00E-57 GO:0008137; GO:0007420; GO:0019933; GO:0045333; GO:0022900; GO:0005747; GO:0032981; GO:0048146; GO:0072593; GO:0001932; GO:0051591 NADH dehydrogenase (ubiquinone) activity; brain development; cAMP-mediated signaling; cellular respiration; electron transport chain; mitochondrial respiratory chain complex I; mitochondrial respiratory chain complex I assembly; positive regulation of fibroblast proliferation; reactive oxygen species metabolic process; regulation of protein phosphorylation; response to cAMP IPR006885; "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (CI-18 kDa) (Complex I-AQDQ) (CI-AQDQ) (NADH-ubiquinone oxidoreductase 18 kDa subunit)" NDUFS4 Bos taurus (Bovine) TR26536_c2_g1_i1 E9Q555 RN213_MOUSE 1.00E-39 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) Rnf213 Mus musculus (Mouse) TR26540_c1_g1_i1 Q8NHV1 GIMA7_HUMAN 2.00E-27 GO:0005525; GO:0003924; GO:0005811 GTP binding; GTPase activity; lipid particle IPR006703; IPR027417; GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) TR26541_c1_g1_i1 Q9UGM3 DMBT1_HUMAN 1.00E-21 GO:0048306; GO:0051607; GO:0030855; GO:0005576; GO:0019898; GO:0043152; GO:0045087; GO:0001833; GO:0019048; GO:0030670; GO:0030858; GO:0015031; GO:0005578; GO:0005044; GO:0008329; GO:0035375; GO:0042589 calcium-dependent protein binding; defense response to virus; epithelial cell differentiation; extracellular region; extrinsic to membrane; induction of bacterial agglutination; innate immune response; inner cell mass cell proliferation; modulation by virus of host morphology or physiology; phagocytic vesicle membrane; positive regulation of epithelial cell differentiation; protein transport; proteinaceous extracellular matrix; scavenger receptor activity; signaling pattern recognition receptor activity; zymogen binding; zymogen granule membrane IPR000859; IPR001190; IPR017448; IPR001507; IPR017977; Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) TR26541_c1_g1_i2 Q5G267 NETR_MACMU 1.00E-18 GO:0030424; GO:0006887; GO:0005576; GO:0005886; GO:0006508; GO:0005044; GO:0004252 axon; exocytosis; extracellular region; plasma membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR001190; IPR017448; IPR009003; Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Macaca mulatta (Rhesus macaque) TR26546_c5_g1_i1 Q6ZT98 TTLL7_HUMAN 7.00E-62 GO:0030154; GO:0005929; GO:0005737; GO:0030425; GO:0016874; GO:0005932; GO:0007399; GO:0043204; GO:0018095 cell differentiation; cilium; cytoplasm; dendrite; ligase activity; microtubule basal body; nervous system development; perikaryon; protein polyglutamylation IPR004344; IPR027745; Tubulin polyglutamylase TTLL7 (EC 6.-.-.-) (Testis development protein NYD-SP30) (Tubulin--tyrosine ligase-like protein 7) TTLL7 Homo sapiens (Human) TR26547_c0_g1_i1 Q969Y2 GTPB3_HUMAN 1.00E-62 GO:0005525; GO:0003924; GO:0005739; GO:0005634; GO:0006400 GTP binding; GTPase activity; mitochondrion; nucleus; tRNA modification IPR018948; IPR006073; IPR004520; IPR025867; IPR027368; IPR027417; IPR005225; IPR027266; "tRNA modification GTPase GTPBP3, mitochondrial (GTP-binding protein 3) (Mitochondrial GTP-binding protein 1)" GTPBP3 MTGP1 Homo sapiens (Human) TR26547_c0_g1_i2 Q8D3I9 MNME_WIGBR 3.00E-28 GO:0005525; GO:0003924; GO:0005737; GO:0046872; GO:0006400 GTP binding; GTPase activity; cytoplasm; metal ion binding; tRNA modification IPR018948; IPR006073; IPR004520; IPR025867; IPR027368; IPR027417; IPR005225; IPR027266; tRNA modification GTPase MnmE (EC 3.6.-.-) mnmE thdF trmE WIGBR0120 Wigglesworthia glossinidia brevipalpis TR26548_c0_g1_i1 Q86ZU6 GLNA_TUBBO 4.00E-41 GO:0005524; GO:0005737; GO:0004356; GO:0006542 ATP binding; cytoplasm; glutamate-ammonia ligase activity; glutamine biosynthetic process IPR008147; IPR014746; IPR008146; IPR027303; IPR027302; Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) GLN1 Tuber borchii (White truffle) TR26548_c2_g1_i1 P09606 GLNA_RAT 1.00E-42 GO:0005524; GO:0019676; GO:0043679; GO:0008283; GO:0016595; GO:0004351; GO:0004356; GO:0006542; GO:0000287; GO:0030145; GO:0005739; GO:0042133; GO:0043204; GO:0050679; GO:0032024; GO:0051968; GO:0043234; GO:0051260; GO:0005791 "ATP binding; ammonia assimilation cycle; axon terminus; cell proliferation; glutamate binding; glutamate decarboxylase activity; glutamate-ammonia ligase activity; glutamine biosynthetic process; magnesium ion binding; manganese ion binding; mitochondrion; neurotransmitter metabolic process; perikaryon; positive regulation of epithelial cell proliferation; positive regulation of insulin secretion; positive regulation of synaptic transmission, glutamatergic; protein complex; protein homooligomerization; rough endoplasmic reticulum" IPR008147; IPR014746; IPR008146; IPR027303; IPR027302; Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate decarboxylase) (EC 4.1.1.15) (Glutamate--ammonia ligase) Glul Glns Rattus norvegicus (Rat) TR26548_c3_g1_i1 P51121 GLNA_XENLA 3.00E-46 GO:0005524; GO:0004351; GO:0004356; GO:0006542; GO:0005739 ATP binding; glutamate decarboxylase activity; glutamate-ammonia ligase activity; glutamine biosynthetic process; mitochondrion IPR008147; IPR014746; IPR008146; IPR027303; IPR027302; Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate decarboxylase) (EC 4.1.1.15) (Glutamate--ammonia ligase) glul Xenopus laevis (African clawed frog) TR26548_c3_g1_i2 Q02154 GLNA2_RHILP 2.00E-19 GO:0005524; GO:0005737; GO:0004356; GO:0006542; GO:0009399 ATP binding; cytoplasm; glutamate-ammonia ligase activity; glutamine biosynthetic process; nitrogen fixation IPR008147; IPR014746; IPR008146; IPR027303; IPR027302; Glutamine synthetase 2 (EC 6.3.1.2) (Glutamate--ammonia ligase II) (Glutamine synthetase II) (GSII) glnII Rhizobium leguminosarum bv. phaseoli TR26551_c0_g1_i1 B7ZRU9 EVI1A_XENLA 4.00E-09 GO:0003677; GO:0046872; GO:0000122; GO:0016607; GO:0039013; GO:0039022; GO:0072196; GO:0006351 "DNA binding; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nuclear speck; pronephric distal tubule morphogenesis; pronephric duct development; proximal/distal pattern formation involved in pronephric nephron development; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; MDS1 and EVI1 complex locus protein EVI1-A (Ecotropic virus integration site 1 protein homolog-A) (Evi-1) (xEvi-1) mecom-a evi1 evi1-a Xenopus laevis (African clawed frog) TR26551_c0_g1_i2 P14404 EVI1_MOUSE 1.00E-10 GO:0003677; GO:0006915; GO:0030154; GO:0035115; GO:0035116; GO:0030900; GO:0071425; GO:0001701; GO:0006954; GO:0046872; GO:0046329; GO:0043069; GO:0045892; GO:0001780; GO:0016607; GO:0060039; GO:0045944; GO:0009791; GO:0042803; GO:0051726; GO:0042127; GO:0072001; GO:0009617; GO:0003700; GO:0006351 Q9Z2D8; Q9Z2D8-1 "DNA binding; apoptotic process; cell differentiation; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; forebrain development; hematopoietic stem cell proliferation; in utero embryonic development; inflammatory response; metal ion binding; negative regulation of JNK cascade; negative regulation of programmed cell death; negative regulation of transcription, DNA-dependent; neutrophil homeostasis; nuclear speck; pericardium development; positive regulation of transcription from RNA polymerase II promoter; post-embryonic development; protein homodimerization activity; regulation of cell cycle; regulation of cell proliferation; renal system development; response to bacterium; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; MDS1 and EVI1 complex locus protein EVI1 (Ecotropic virus integration site 1 protein) (EVI-1) Mecom Evi1 Mus musculus (Mouse) TR26551_c1_g1_i1 Q12901 ZN155_HUMAN 2.00E-33 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 155 ZNF155 Homo sapiens (Human) TR26555_c1_g1_i1 Q9H8J5 MANS1_HUMAN 6.00E-07 GO:0016021 integral to membrane IPR013980; IPR011106; MANSC domain-containing protein 1 (Loss of heterozygosity 12 chromosomal region 3 protein) MANSC1 LOH12CR3 UNQ316/PRO361 Homo sapiens (Human) TR26559_c0_g1_i1 Q9DBJ6 JOS1_MOUSE 7.00E-58 GO:0005737; GO:0008242; GO:0005886; GO:0006508 cytoplasm; omega peptidase activity; plasma membrane; proteolysis IPR006155; Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein 1) Josd1 Mus musculus (Mouse) TR2656_c0_g2_i1 Q9BUT9 F195A_HUMAN 1.00E-20 Protein FAM195A FAM195A C16orf14 Homo sapiens (Human) TR26560_c0_g2_i1 Q7KVA1 XYLT_DROME 1.00E-64 GO:0042732; GO:0000139; GO:0008375; GO:0030206; GO:0005789; GO:0015012; GO:0016021; GO:0030158 D-xylose metabolic process; Golgi membrane; acetylglucosaminyltransferase activity; chondroitin sulfate biosynthetic process; endoplasmic reticulum membrane; heparan sulfate proteoglycan biosynthetic process; integral to membrane; protein xylosyltransferase activity IPR003406; IPR002889; IPR024448; Glycan metabolism; chondroitin sulfate biosynthesis. Glycan metabolism; heparan sulfate biosynthesis. Xylosyltransferase oxt (EC 2.4.2.26) (Imaginal disk type I) (Peptide O-xylosyltransferase) oxt CG17771 CG32300 Drosophila melanogaster (Fruit fly) TR26561_c0_g1_i1 P50729 RECS_BACSU 3.00E-38 GO:0005524; GO:0008026; GO:0003677; GO:0006310 ATP binding; ATP-dependent helicase activity; DNA binding; DNA recombination IPR011545; IPR002464; IPR004589; IPR014001; IPR001650; IPR027417; Probable ATP-dependent DNA helicase RecS (EC 3.6.4.12) (Recombination protein S) recS ypbC BSU23020 Bacillus subtilis (strain 168) TR26562_c12_g1_i1 P16157 ANK1_HUMAN 6.00E-13 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR26562_c14_g1_i1 Q4UMH6 Y381_RICFE 3.00E-17 GO:0015969 guanosine tetraphosphate metabolic process IPR002110; IPR020683; IPR007685; Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR26562_c14_g1_i2 Q502K3 ANR52_DANRE 1.00E-14 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) TR26562_c19_g1_i1 Q54BA2 Y3800_DICDI 2.00E-08 IPR002110; IPR020683; IPR001487; IPR018359; IPR000210; IPR011333; IPR013069; IPR027353; "Ankyrin repeat, bromo and BTB domain-containing protein DDB_G0293800" DDB_G0293800 Dictyostelium discoideum (Slime mold) TR26564_c0_g1_i1 Q8NCU4 K1407_HUMAN 7.00E-07 IPR026174; Coiled-coil domain-containing protein KIAA1407 KIAA1407 Homo sapiens (Human) TR26565_c0_g1_i1 Q6AXK4 BABA1_DANRE 3.00E-49 GO:0070531; GO:0070552; GO:0031572; GO:0016568; GO:0005737; GO:0006302; GO:0045739; GO:0070536; GO:0010212 BRCA1-A complex; BRISC complex; G2 DNA damage checkpoint; chromatin modification; cytoplasm; double-strand break repair; positive regulation of DNA repair; protein K63-linked deubiquitination; response to ionizing radiation IPR026126; BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) babam1 merit40 nba1 Zgc:100909 Danio rerio (Zebrafish) (Brachydanio rerio) TR26570_c1_g1_i1 Q0P5C2 MTDC_BOVIN 1.00E-104 GO:0009396; GO:0000287; GO:0004477; GO:0004487; GO:0004488; GO:0005739; GO:0006730; GO:0042301; GO:0046653 folic acid-containing compound biosynthetic process; magnesium ion binding; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; methylenetetrahydrofolate dehydrogenase (NADP+) activity; mitochondrion; one-carbon metabolic process; phosphate ion binding; tetrahydrofolate metabolic process IPR016040; IPR000672; IPR020630; IPR020867; IPR020631; "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]" MTHFD2 Bos taurus (Bovine) TR26572_c2_g1_i1 Q5UPI6 YL112_MIMIV 2.00E-07 IPR002110; IPR020683; Putative ankyrin repeat protein L112 MIMI_L112 Acanthamoeba polyphaga mimivirus (APMV) TR26574_c2_g1_i1 Q5XHB2 DUS22_XENTR 8.00E-59 GO:0005737; GO:0005634; GO:0035335; GO:0046330; GO:0004725; GO:0008138; GO:0042127; GO:0007179 cytoplasm; nucleus; peptidyl-tyrosine dephosphorylation; positive regulation of JNK cascade; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; regulation of cell proliferation; transforming growth factor beta receptor signaling pathway IPR020417; IPR000340; IPR020422; IPR024950; IPR000387; Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) dusp22 TEgg009e03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR26578_c0_g1_i1 Q7ZWF4 RN145_DANRE 1.00E-06 GO:0016021; GO:0008270 integral to membrane; zinc ion binding IPR025754; IPR001841; IPR013083; RING finger protein 145 rnf145 zgc:56435 Danio rerio (Zebrafish) (Brachydanio rerio) TR26584_c0_g1_i1 Q9BI23 YELL_DROER 1.00E-26 GO:0005576; GO:0007275 extracellular region; multicellular organismal development IPR011042; IPR017996; IPR003534; Protein yellow y Drosophila erecta (Fruit fly) TR26586_c2_g1_i1 O43734 CIKS_HUMAN 4.00E-12 GO:0001783; GO:0006959; GO:0048305; GO:0035556; GO:0043123 B cell apoptotic process; humoral immune response; immunoglobulin secretion; intracellular signal transduction; positive regulation of I-kappaB kinase/NF-kappaB cascade IPR013568; Adapter protein CIKS (Connection to IKK and SAPK/JNK) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2) TRAF3IP2 C6orf2 C6orf4 C6orf5 C6orf6 Homo sapiens (Human) TR26590_c0_g1_i1 Q13395 TARB1_HUMAN 7.00E-166 GO:0003723; GO:0001510; GO:0008173; GO:0006396; GO:0005634; GO:0006357 RNA binding; RNA methylation; RNA methyltransferase activity; RNA processing; nucleus; regulation of transcription from RNA polymerase II promoter IPR016024; IPR025806; IPR001537; Probable methyltransferase TARBP1 (EC 2.1.1.-) (TAR RNA-binding protein 1) (TAR RNA-binding protein of 185 kDa) (TRP-185) TARBP1 TRM3 TRP185 Homo sapiens (Human) TR26591_c4_g1_i1 Q9H9D4 ZN408_HUMAN 2.00E-14 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 Itself; Q8NHQ1; Q13868; Q14192; O95751; Q9Y333; Q99750 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 408 (PR domain zinc finger protein 17) ZNF408 PFM14 PRDM17 Homo sapiens (Human) TR26593_c3_g1_i2 Q8BMQ2 TF3C4_MOUSE 2.00E-09 GO:0003677; GO:0016573; GO:0004402; GO:0000127; GO:0006351 "DNA binding; histone acetylation; histone acetyltransferase activity; transcription factor TFIIIC complex; transcription, DNA-dependent" IPR024761; IPR024764; IPR017986; General transcription factor 3C polypeptide 4 (EC 2.3.1.48) (TF3C-delta) (Transcription factor IIIC 90 kDa subunit) (TFIIIC 90 kDa subunit) (TFIIIC90) (Transcription factor IIIC subunit delta) Gtf3c4 Mus musculus (Mouse) TR26594_c3_g1_i1 Q962P8 TBA6_NAEGR 1.00E-85 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005819; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; spindle; structural constituent of cytoskeleton IPR002452; IPR013838; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-6 chain TUBA6 Naegleria gruberi (Amoeba) TR26594_c3_g2_i1 P11833 TBB_PARLI 0 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR013838; IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta chain (Beta-tubulin) Paracentrotus lividus (Common sea urchin) TR26594_c3_g2_i2 P33632 TBB3_ANEPH 2.00E-64 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR003008; Tubulin beta-3 chain (Beta-3-tubulin) (Fragment) TUBB3 Anemia phyllitidis (Fern) (Osmunda phyllitidis) TR26594_c3_g3_i1 P33628 TBA_PICAB 3.00E-28 GO:0005525; GO:0005737; GO:0005874; GO:0007017; GO:0005200 GTP binding; cytoplasm; microtubule; microtubule-based process; structural constituent of cytoskeleton IPR002452; IPR000217; IPR003008; Tubulin alpha chain (Fragment) TUBA Picea abies (Norway spruce) (Picea excelsa) TR26598_c0_g1_i1 A9ULZ2 BIR7B_XENLA 7.00E-66 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) TR26601_c1_g1_i1 P10351 XDH_DROME 5.00E-84 GO:0051537; GO:0008762; GO:0006525; GO:0048072; GO:0008340; GO:0009055; GO:0050660; GO:0006650; GO:0005506; GO:0005875; GO:0043546; GO:0005777; GO:0006206; GO:0006568; GO:0009115; GO:0004854; GO:0004855 "2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; arginine metabolic process; compound eye pigmentation; determination of adult lifespan; electron carrier activity; flavin adenine dinucleotide binding; glycerophospholipid metabolic process; iron ion binding; microtubule associated complex; molybdopterin cofactor binding; peroxisome; pyrimidine nucleobase metabolic process; tryptophan metabolic process; xanthine catabolic process; xanthine dehydrogenase activity; xanthine oxidase activity" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; IPR022407; IPR014307; Xanthine dehydrogenase (XD) (EC 1.17.1.4) (Protein rosy locus) ry XDH CG7642 Drosophila melanogaster (Fruit fly) TR26604_c0_g1_i1 Q60847 COCA1_MOUSE 2.00E-26 GO:0007155; GO:0005581; GO:0005615; GO:0070062 cell adhesion; collagen; extracellular space; extracellular vesicular exosome IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain Col12a1 Mus musculus (Mouse) TR26605_c0_g1_i1 Q8BXX9 CC169_MOUSE 2.00E-11 IPR028022; Coiled-coil domain-containing protein 169 Ccdc169 Mus musculus (Mouse) TR26605_c0_g1_i2 A6NNP5 CC169_HUMAN 3.00E-27 IPR028022; Coiled-coil domain-containing protein 169 CCDC169 C13orf38 Homo sapiens (Human) TR26605_c0_g1_i4 Q3KPT0 CC169_XENLA 1.00E-24 IPR028022; Coiled-coil domain-containing protein 169 ccdc169 Xenopus laevis (African clawed frog) TR26606_c0_g1_i1 Q9U9Y8 NLK_CAEEL 2.00E-39 GO:0005524; GO:0004707; GO:0000165; GO:0016055; GO:0008356; GO:0045167; GO:0005938; GO:0001714; GO:0046872; GO:0042694; GO:0005634; GO:0010085; GO:0004674 Q21636; Q18171; Q10953; O76449 ATP binding; MAP kinase activity; MAPK cascade; Wnt receptor signaling pathway; asymmetric cell division; asymmetric protein localization involved in cell fate determination; cell cortex; endodermal cell fate specification; metal ion binding; muscle cell fate specification; nucleus; polarity specification of proximal/distal axis; protein serine/threonine kinase activity IPR011009; IPR003527; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine kinase NLK (EC 2.7.11.24) (Loss of intestine protein 1) (Nemo-like kinase) lit-1 nlk W06F12.1 Caenorhabditis elegans TR26606_c0_g2_i1 P49615 CDK5_MOUSE 0 GO:0005524; GO:0005176; GO:0043125; GO:0014044; GO:0030549; GO:0030424; GO:0048148; GO:0070509; GO:0051301; GO:0030054; GO:0007160; GO:0021954; GO:0021697; GO:0022038; GO:0030866; GO:0016533; GO:0004693; GO:0005829; GO:0030425; GO:0048813; GO:0009790; GO:0030175; GO:0030426; GO:0021766; GO:0006886; GO:0030027; GO:0021819; GO:0016020; GO:0008045; GO:0030517; GO:0045786; GO:0046826; GO:0031397; GO:0031914; GO:0045892; GO:0031594; GO:0051402; GO:0001764; GO:0043025; GO:0006913; GO:0005634; GO:0048709; GO:0018107; GO:0043204; GO:0045956; GO:0043525; GO:0032092; GO:0045860; GO:0090314; GO:0014069; GO:0045211; GO:0046777; GO:0035418; GO:0032801; GO:0043113; GO:0045055; GO:0030334; GO:0061001; GO:0060079; GO:0009611; GO:0019233; GO:0033136; GO:0007519; GO:0007416; GO:0001963; GO:0035249; GO:0048488; GO:0050321; GO:0008542 P61809 "ATP binding; ErbB-2 class receptor binding; ErbB-3 class receptor binding; Schwann cell development; acetylcholine receptor activator activity; axon; behavioral response to cocaine; calcium ion import; cell division; cell junction; cell-matrix adhesion; central nervous system neuron development; cerebellar cortex formation; corpus callosum development; cortical actin cytoskeleton organization; cyclin-dependent protein kinase 5 holoenzyme complex; cyclin-dependent protein serine/threonine kinase activity; cytosol; dendrite; dendrite morphogenesis; embryo development; filopodium; growth cone; hippocampus development; intracellular protein transport; lamellipodium; layer formation in cerebral cortex; membrane; motor neuron axon guidance; negative regulation of axon extension; negative regulation of cell cycle; negative regulation of protein export from nucleus; negative regulation of protein ubiquitination; negative regulation of synaptic plasticity; negative regulation of transcription, DNA-dependent; neuromuscular junction; neuron apoptotic process; neuron migration; neuronal cell body; nucleocytoplasmic transport; nucleus; oligodendrocyte differentiation; peptidyl-threonine phosphorylation; perikaryon; positive regulation of calcium ion-dependent exocytosis; positive regulation of neuron apoptotic process; positive regulation of protein binding; positive regulation of protein kinase activity; positive regulation of protein targeting to membrane; postsynaptic density; postsynaptic membrane; protein autophosphorylation; protein localization to synapse; receptor catabolic process; receptor clustering; regulated secretory pathway; regulation of cell migration; regulation of dendritic spine morphogenesis; regulation of excitatory postsynaptic membrane potential; response to wounding; sensory perception of pain; serine phosphorylation of STAT3 protein; skeletal muscle tissue development; synapse assembly; synaptic transmission, dopaminergic; synaptic transmission, glutamatergic; synaptic vesicle endocytosis; tau-protein kinase activity; visual learning" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 5 (EC 2.7.11.22) (CR6 protein kinase) (CRK6) (Cell division protein kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) Cdk5 Cdkn5 Crk6 Mus musculus (Mouse) TR26607_c0_g2_i1 Q6QUY7 ECTD_STRAQ 1.00E-14 GO:0016725 "oxidoreductase activity, acting on CH or CH2 groups" IPR012774; IPR008775; Ectoine hydroxylase (EC 1.17.-.-) ectD thpD Streptomyces anulatus (Streptomyces chrysomallus) TR26607_c0_g2_i2 Q5YW75 ECTD_NOCFA 3.00E-17 GO:0016725 "oxidoreductase activity, acting on CH or CH2 groups" IPR012774; IPR008775; Ectoine hydroxylase (EC 1.17.-.-) ectD NFA_27190 Nocardia farcinica (strain IFM 10152) TR2661_c0_g1_i1 Q9R0J8 LGMN_RAT 1.00E-40 GO:0004197; GO:0005764; GO:1901185; GO:0051603; GO:0032801; GO:0003014 cysteine-type endopeptidase activity; lysosome; negative regulation of ERBB signaling pathway; proteolysis involved in cellular protein catabolic process; receptor catabolic process; renal system process IPR001096; "Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1)" Lgmn Prsc1 Rattus norvegicus (Rat) TR26611_c0_g1_i1 Q2KID6 PLRG1_BOVIN 0 GO:0008380; GO:0071013; GO:0006397; GO:0016607 RNA splicing; catalytic step 2 spliceosome; mRNA processing; nuclear speck IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Pleiotropic regulator 1 PLRG1 Bos taurus (Bovine) TR26613_c3_g1_i1 E9Q555 RN213_MOUSE 5.00E-16 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) Rnf213 Mus musculus (Mouse) TR26618_c2_g1_i1 O75460 ERN1_HUMAN 6.00E-72 GO:0005524; GO:0070055; GO:0006987; GO:0006915; GO:0007050; GO:0004521; GO:0030176; GO:0000287; GO:0005739; GO:0005637; GO:1900103; GO:0046777; GO:0004674; GO:0006355; GO:0006351 Itself; O08734; Q07812; Q07813; P20029; Q86TM6; Q9H2K8; Q12933 "ATP binding; HAC1-type intron splice site recognition and cleavage; activation of signaling protein activity involved in unfolded protein response; apoptotic process; cell cycle arrest; endoribonuclease activity; integral to endoplasmic reticulum membrane; magnesium ion binding; mitochondrion; nuclear inner membrane; positive regulation of endoplasmic reticulum unfolded protein response; protein autophosphorylation; protein serine/threonine kinase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR010513; IPR011009; IPR018391; IPR000719; IPR006567; IPR027295; IPR011047; IPR008271; Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] ERN1 IRE1 Homo sapiens (Human) TR26618_c2_g2_i1 Q54WS5 ROCO6_DICDI 5.00E-06 GO:0005524; GO:0005525; GO:0016021; GO:0005543; GO:0004674; GO:0007264 ATP binding; GTP binding; integral to membrane; phospholipid binding; protein serine/threonine kinase activity; small GTPase mediated signal transduction IPR011009; IPR001611; IPR025875; IPR003591; IPR027417; IPR011993; IPR001849; IPR000719; IPR017441; IPR011047; IPR020859; IPR001245; IPR008271; IPR001806; IPR015943; IPR001680; Probable serine/threonine-protein kinase roco6 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 6) roco6 DDB_G0279417 Dictyostelium discoideum (Slime mold) TR26619_c0_g1_i1 P41596 DOPR1_DROME 8.00E-90 GO:0007191; GO:0071329; GO:0001588; GO:0005887; GO:0007613; GO:0090328; GO:0042594; GO:0040040; GO:0043052; GO:0008542 "adenylate cyclase-activating dopamine receptor signaling pathway; cellular response to sucrose stimulus; dopamine neurotransmitter receptor activity, coupled via Gs; integral to plasma membrane; memory; regulation of olfactory learning; response to starvation; thermosensory behavior; thermotaxis; visual learning" IPR000929; IPR000276; IPR017452; Dopamine receptor 1 (D-DOP1) (DmDop1) (dDA1) DopR DopR1 DopR35EF CG9652 Drosophila melanogaster (Fruit fly) TR26619_c0_g1_i2 Q16950 5HTB1_APLCA 4.00E-65 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR000276; IPR017452; 5-hydroxytryptamine receptor 1 (5-HTB1) (Serotonin receptor 1) 5HTB1 Aplysia californica (California sea hare) TR26619_c0_g1_i3 Q8IS44 DRD2L_DROME 2.00E-21 GO:0008227; GO:0004952; GO:0016021; GO:0005887 G-protein coupled amine receptor activity; dopamine neurotransmitter receptor activity; integral to membrane; integral to plasma membrane IPR000929; IPR000276; IPR017452; Dopamine D2-like receptor (DD2R) D2R CG17004 Drosophila melanogaster (Fruit fly) TR26620_c2_g1_i1 Q86XT4 TRI50_HUMAN 2.00E-10 GO:0005737; GO:0043231; GO:0016874; GO:0008270 cytoplasm; intracellular membrane-bounded organelle; ligase activity; zinc ion binding IPR001870; IPR003879; IPR008985; IPR006574; IPR003877; IPR000315; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM50 (EC 6.3.2.-) (Tripartite motif-containing protein 50) TRIM50 TRIM50A Homo sapiens (Human) TR26620_c2_g1_i2 Q8BFW4 TRI65_MOUSE 4.00E-09 GO:0008270 zinc ion binding IPR001870; IPR003879; IPR008985; IPR006574; IPR003877; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 65 Trim65 Mus musculus (Mouse) TR26620_c2_g1_i3 Q810I2 TRI50_MOUSE 2.00E-11 GO:0016235; GO:0005737; GO:0016874; GO:0070201; GO:0008270 aggresome; cytoplasm; ligase activity; regulation of establishment of protein localization; zinc ion binding IPR001870; IPR003879; IPR008985; IPR006574; IPR018355; IPR003877; IPR027370; IPR000315; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM50 (EC 6.3.2.-) (Tripartite motif-containing protein 50) Trim50 Mus musculus (Mouse) TR26621_c1_g1_i1 Q7XA72 AB21G_ARATH 8.00E-24 GO:0005524; GO:0006200; GO:0016887; GO:0016021; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; integral to membrane; transport IPR003593; IPR013525; IPR003439; IPR017871; IPR027417; ABC transporter G family member 21 (ABC transporter ABCG.21) (AtABCG21) (White-brown complex homolog protein 21) (AtWBC21) ABCG21 WBC21 At3g25620 T5M7.6 Arabidopsis thaliana (Mouse-ear cress) TR26628_c4_g1_i1 O61366 GPRS_DROME 3.00E-21 IPR011705; IPR000210; IPR011333; IPR013069; Serine-enriched protein gprs CG18471 Drosophila melanogaster (Fruit fly) TR26628_c5_g1_i1 Q9BXT6 M10L1_HUMAN 4.00E-52 GO:0005524; GO:0004004; GO:0003723; GO:0007281; GO:0005622; GO:0000287; GO:0007275; GO:0007283 ATP binding; ATP-dependent RNA helicase activity; RNA binding; germ cell development; intracellular; magnesium ion binding; multicellular organismal development; spermatogenesis IPR026125; IPR027417; Putative helicase Mov10l1 (EC 3.6.4.13) (Moloney leukemia virus 10-like protein 1) (MOV10-like protein 1) MOV10L1 Homo sapiens (Human) TR26633_c1_g1_i3 Q8VYA5 RSZ33_ARATH 4.00E-19 GO:0016607; GO:0003676; GO:0000166; GO:0000245; GO:0008270 nuclear speck; nucleic acid binding; nucleotide binding; spliceosomal complex assembly; zinc ion binding IPR012677; IPR000504; IPR001878; Serine/arginine-rich splicing factor RS2Z33 (RS-containing zinc finger protein 33) (At-RS2Z33) (At-RSZ33) RS2Z33 RSZ33 At2g37340 F3G5.13 Arabidopsis thaliana (Mouse-ear cress) TR26636_c3_g1_i1 P86854 PLCL_MYTGA 4.00E-15 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR26636_c3_g2_i1 P02707 LECH_CHICK 2.00E-14 GO:0030246; GO:0006897; GO:0016021 carbohydrate binding; endocytosis; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; Hepatic lectin Gallus gallus (Chicken) TR26637_c0_g1_i2 Q3UMF9 FAXC_MOUSE 9.00E-51 GO:0016021 integral to membrane IPR026928; IPR010987; IPR012336; Failed axon connections homolog Faxc Mus musculus (Mouse) TR26639_c2_g1_i1 Q5W0Q7 USPL1_HUMAN 9.00E-32 GO:0015030; GO:0030576; GO:0032183; GO:0070140; GO:0008283; GO:0016926; GO:0004221; GO:0006511 P63165; P61956; P55854 Cajal body; Cajal body organization; SUMO binding; SUMO-specific isopeptidase activity; cell proliferation; protein desumoylation; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR001394; SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) USPL1 C13orf22 D13S106 Homo sapiens (Human) TR26643_c0_g1_i1 P56705 WNT4_HUMAN 1.00E-28 GO:0005796; GO:0030325; GO:0006702; GO:0001658; GO:0060070; GO:0045165; GO:0009986; GO:0007267; GO:0071560; GO:0001838; GO:0005788; GO:0001837; GO:0090002; GO:0005201; GO:0005615; GO:0008585; GO:0030237; GO:0005109; GO:0033080; GO:0001889; GO:0008584; GO:0061180; GO:0060231; GO:0072164; GO:0072162; GO:0072273; GO:0043066; GO:0090090; GO:0045596; GO:0030336; GO:0040037; GO:2000019; GO:0061369; GO:2000225; GO:0045892; GO:0061045; GO:0030182; GO:0038030; GO:0048599; GO:0061205; GO:0005886; GO:0032321; GO:0032349; GO:0030501; GO:0090263; GO:0032967; GO:2000066; GO:0061184; GO:0051894; GO:0045836; GO:0045669; GO:0051496; GO:0045893; GO:0018345; GO:0005578; GO:0048018; GO:0022407; GO:0072033; GO:0072034; GO:0051145; GO:0060126; GO:0060748; GO:0060129; GO:0003714 "Golgi lumen; adrenal gland development; androgen biosynthetic process; branching involved in ureteric bud morphogenesis; canonical Wnt receptor signaling pathway; cell fate commitment; cell surface; cell-cell signaling; cellular response to transforming growth factor beta stimulus; embryonic epithelial tube formation; endoplasmic reticulum lumen; epithelial to mesenchymal transition; establishment of protein localization to plasma membrane; extracellular matrix structural constituent; extracellular space; female gonad development; female sex determination; frizzled binding; immature T cell proliferation in thymus; liver development; male gonad development; mammary gland epithelium development; mesenchymal to epithelial transition; mesonephric tubule development; metanephric mesenchymal cell differentiation; metanephric nephron morphogenesis; negative regulation of apoptotic process; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of cell differentiation; negative regulation of cell migration; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of male gonad development; negative regulation of testicular blood vessel morphogenesis; negative regulation of testosterone biosynthetic process; negative regulation of transcription, DNA-dependent; negative regulation of wound healing; neuron differentiation; non-canonical Wnt receptor signaling pathway via MAPK cascade; oocyte development; paramesonephric duct development; plasma membrane; positive regulation of Rho GTPase activity; positive regulation of aldosterone biosynthetic process; positive regulation of bone mineralization; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of collagen biosynthetic process; positive regulation of cortisol biosynthetic process; positive regulation of dermatome development; positive regulation of focal adhesion assembly; positive regulation of meiosis; positive regulation of osteoblast differentiation; positive regulation of stress fiber assembly; positive regulation of transcription, DNA-dependent; protein palmitoylation; proteinaceous extracellular matrix; receptor agonist activity; regulation of cell-cell adhesion; renal vesicle formation; renal vesicle induction; smooth muscle cell differentiation; somatotropin secreting cell differentiation; tertiary branching involved in mammary gland duct morphogenesis; thyroid-stimulating hormone-secreting cell differentiation; transcription corepressor activity" IPR005817; IPR009142; IPR018161; Protein Wnt-4 WNT4 UNQ426/PRO864 Homo sapiens (Human) TR26649_c1_g1_i1 Q8NEN0 ARMC2_HUMAN 1.00E-20 IPR011989; IPR016024; Armadillo repeat-containing protein 2 ARMC2 Homo sapiens (Human) TR26649_c2_g1_i1 Q8NEN0 ARMC2_HUMAN 7.00E-58 IPR011989; IPR016024; Armadillo repeat-containing protein 2 ARMC2 Homo sapiens (Human) TR26651_c0_g1_i1 Q90WJ8 AJL2_ANGJA 9.00E-16 GO:0030246; GO:0050829; GO:0005576; GO:0043152 carbohydrate binding; defense response to Gram-negative bacterium; extracellular region; induction of bacterial agglutination IPR001304; IPR016186; IPR018378; IPR016187; Lactose-binding lectin l-2 (Ajl-2) l-2 Anguilla japonica (Japanese eel) TR26652_c0_g1_i1 Q1LU86 F92A1_DANRE 6.00E-37 IPR009602; Protein FAM92A1 fam92a1 si:dkey-98l21.1 zgc:100998 Danio rerio (Zebrafish) (Brachydanio rerio) TR26652_c0_g1_i2 Q1RMK1 FA92B_BOVIN 8.00E-41 IPR027267; IPR009602; Protein FAM92B FAM92B Bos taurus (Bovine) TR26652_c0_g1_i3 Q3SZG6 F92A1_BOVIN 1.00E-36 IPR009602; Protein FAM92A1 FAM92A1 Bos taurus (Bovine) TR26655_c0_g1_i3 Q8K2P6 RFESD_MOUSE 6.00E-34 GO:0051537; GO:0046872; GO:0016491 "2 iron, 2 sulfur cluster binding; metal ion binding; oxidoreductase activity" IPR017941; Rieske domain-containing protein Rfesd Mus musculus (Mouse) TR26656_c0_g1_i1 Q0IJ20 RN145_XENTR 8.00E-15 GO:0016021; GO:0008270 integral to membrane; zinc ion binding IPR025754; IPR001841; IPR013083; RING finger protein 145 rnf145 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR26660_c2_g2_i1 Q28FY0 TILB_XENTR 3.00E-50 GO:0005929; GO:0005737 cilium; cytoplasm IPR001611; IPR003603; Protein tilB homolog (Leucine-rich repeat-containing protein 6) lrrc6 TGas012h22.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR26660_c3_g1_i1 B3DH20 TILB_DANRE 1.00E-37 GO:0005929; GO:0005737 cilium; cytoplasm IPR001611; IPR003603; Protein tilB homolog (Leucine-rich repeat-containing 6-like protein) (Leucine-rich repeat-containing protein 6) (Seahorse) lrrc6 lrrc6l Danio rerio (Zebrafish) (Brachydanio rerio) TR26662_c0_g2_i1 Q9Y233 PDE10_HUMAN 4.00E-158 GO:0047555; GO:0007596; GO:0030552; GO:0006198; GO:0030553; GO:0046069; GO:0004118; GO:0005829; GO:0046872; GO:0043949; GO:0010738; GO:0007165 "3',5'-cyclic-GMP phosphodiesterase activity; blood coagulation; cAMP binding; cAMP catabolic process; cGMP binding; cGMP catabolic process; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cytosol; metal ion binding; regulation of cAMP-mediated signaling; regulation of protein kinase A signaling cascade; signal transduction" IPR003018; IPR003607; IPR023088; IPR002073; IPR023174; "Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1." "cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17) (EC 3.1.4.35)" PDE10A Homo sapiens (Human) TR26663_c1_g1_i1 Q8C0R7 ZMY15_MOUSE 3.00E-32 GO:0005737; GO:0042826; GO:0046872; GO:0045892; GO:0005634; GO:0007286; GO:0006351 "cytoplasm; histone deacetylase binding; metal ion binding; negative regulation of transcription, DNA-dependent; nucleus; spermatid development; transcription, DNA-dependent" IPR002893; Zinc finger MYND domain-containing protein 15 Zmynd15 Mus musculus (Mouse) TR26666_c0_g1_i1 Q5RFP4 OZF_PONAB 2.00E-28 GO:0003677; GO:0005737; GO:0046872; GO:0005730 DNA binding; cytoplasm; metal ion binding; nucleolus IPR007087; IPR015880; IPR013087; Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146) ZNF146 OZF Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR26666_c0_g2_i1 Q60821 ZBT17_MOUSE 1.00E-17 GO:0003677; GO:0007398; GO:0001702; GO:0046872; GO:0005634; GO:0045893; GO:0003700; GO:0006351 "DNA binding; ectoderm development; gastrulation with mouth forming second; metal ion binding; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 17 (LP-1) (Polyomavirus late initiator promoter-binding protein) (Zinc finger protein 100) (Zfp-100) (Zinc finger protein 151) (Zinc finger protein Z13) Zbtb17 Zfp100 Znf151 Mus musculus (Mouse) TR26667_c0_g1_i1 P07704 CYB_DROYA 9.00E-166 GO:0009055; GO:0016021; GO:0046872; GO:0005743; GO:0016491; GO:0070469; GO:0022904 electron carrier activity; integral to membrane; metal ion binding; mitochondrial inner membrane; oxidoreductase activity; respiratory chain; respiratory electron transport chain IPR016175; IPR005798; IPR005797; IPR027387; IPR016174; Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit) mt:Cyt-b Cob cytb Drosophila yakuba (Fruit fly) TR26668_c0_g1_i1 Q6UX65 DRAM2_HUMAN 3.00E-14 GO:0005794; GO:0030262; GO:0016021; GO:0005765; GO:0005764 Golgi apparatus; apoptotic nuclear changes; integral to membrane; lysosomal membrane; lysosome IPR027315; IPR019402; DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77) DRAM2 TMEM77 PSEC0031 UNQ154/PRO180 Homo sapiens (Human) TR26671_c0_g1_i1 Q95M17 CHIA_BOVIN 6.00E-55 GO:0006915; GO:0008061; GO:0006032; GO:0004568; GO:0005737; GO:0005615; GO:0000272; GO:0090197; GO:0002532 apoptotic process; chitin binding; chitin catabolic process; chitinase activity; cytoplasm; extracellular space; polysaccharide catabolic process; positive regulation of chemokine secretion; production of molecular mediator involved in inflammatory response IPR002557; IPR011583; IPR001223; IPR001579; IPR013781; IPR017853; Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Chitin-binding protein b04) (CBPb04) CHIA Bos taurus (Bovine) TR26672_c1_g3_i2 P98164 LRP2_HUMAN 3.00E-37 GO:0005794; GO:0016324; GO:0031526; GO:0005509; GO:0008283; GO:0005905; GO:0030139; GO:0005783; GO:0005768; GO:0030900; GO:0016021; GO:0005765; GO:0007603; GO:0006486; GO:0006898; GO:0001523; GO:0042359 "Golgi apparatus; apical plasma membrane; brush border membrane; calcium ion binding; cell proliferation; coated pit; endocytic vesicle; endoplasmic reticulum; endosome; forebrain development; integral to membrane; lysosomal membrane; phototransduction, visible light; protein glycosylation; receptor-mediated endocytosis; retinoid metabolic process; vitamin D metabolic process" IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; IPR019825; Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) LRP2 Homo sapiens (Human) TR26672_c1_g3_i3 P35951 LDLR_MOUSE 2.00E-27 GO:0005794; GO:0005509; GO:0009986; GO:0042632; GO:0070508; GO:0008203; GO:0005905; GO:0005769; GO:0009897; GO:0016021; GO:0030299; GO:0005770; GO:0042159; GO:0034362; GO:0030169; GO:0034383; GO:0005041; GO:0005764; GO:0015914; GO:0005886; GO:0010867; GO:0010899; GO:0030229 Golgi apparatus; calcium ion binding; cell surface; cholesterol homeostasis; cholesterol import; cholesterol metabolic process; coated pit; early endosome; external side of plasma membrane; integral to membrane; intestinal cholesterol absorption; late endosome; lipoprotein catabolic process; low-density lipoprotein particle; low-density lipoprotein particle binding; low-density lipoprotein particle clearance; low-density lipoprotein receptor activity; lysosome; phospholipid transport; plasma membrane; positive regulation of triglyceride biosynthetic process; regulation of phosphatidylcholine catabolic process; very-low-density lipoprotein particle receptor activity IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor (LDL receptor) Ldlr Mus musculus (Mouse) TR26677_c0_g2_i1 Q5REG4 DTX3_PONAB 2.00E-56 GO:0007219; GO:0005737; GO:0016874; GO:0016567; GO:0008270 Notch signaling pathway; cytoplasm; ligase activity; protein ubiquitination; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase DTX3 (EC 6.3.2.-) (Protein deltex-3) (Deltex3) DTX3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR26679_c0_g1_i1 O45947 GLT10_CAEEL 2.00E-90 GO:0000139; GO:0016021; GO:0046872; GO:0004653; GO:0006486 Golgi membrane; integral to membrane; metal ion binding; polypeptide N-acetylgalactosaminyltransferase activity; protein glycosylation IPR001173; IPR000772; Protein modification; protein glycosylation. Putative polypeptide N-acetylgalactosaminyltransferase 10 (pp-GaNTase 10) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 10) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10) gly-10 Y45F10D.3 Caenorhabditis elegans TR26679_c1_g1_i1 O45947 GLT10_CAEEL 6.00E-44 GO:0000139; GO:0016021; GO:0046872; GO:0004653; GO:0006486 Golgi membrane; integral to membrane; metal ion binding; polypeptide N-acetylgalactosaminyltransferase activity; protein glycosylation IPR001173; IPR000772; Protein modification; protein glycosylation. Putative polypeptide N-acetylgalactosaminyltransferase 10 (pp-GaNTase 10) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 10) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10) gly-10 Y45F10D.3 Caenorhabditis elegans TR26680_c0_g1_i1 Q86YS6 RAB43_HUMAN 8.00E-83 GO:0005525; GO:0003924; GO:0005794; GO:0007030; GO:0045335; GO:0030670; GO:0090382; GO:0015031; GO:0035526; GO:0007264 "GTP binding; GTPase activity; Golgi apparatus; Golgi organization; phagocytic vesicle; phagocytic vesicle membrane; phagosome maturation; protein transport; retrograde transport, plasma membrane to Golgi; small GTPase mediated signal transduction" IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-43 (Ras-related protein Rab-41) RAB43 RAB41 Homo sapiens (Human) TR26681_c1_g1_i1 Q6ZW76 ANKS3_HUMAN 1.00E-76 IPR002110; IPR020683; IPR001660; IPR013761; IPR011510; Ankyrin repeat and SAM domain-containing protein 3 ANKS3 KIAA1977 Homo sapiens (Human) TR26681_c2_g2_i1 Q9H694 BICC1_HUMAN 1.00E-06 GO:0003723; GO:0007275; GO:0090090 RNA binding; multicellular organismal development; negative regulation of canonical Wnt receptor signaling pathway IPR004087; IPR004088; IPR001660; IPR013761; IPR021129; Protein bicaudal C homolog 1 (Bic-C) BICC1 Homo sapiens (Human) TR26683_c6_g1_i2 Q6ZN57 ZFP2_HUMAN 3.00E-71 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 2 homolog (Zfp-2) (Zinc finger protein 751) ZFP2 ZNF751 Homo sapiens (Human) TR26683_c6_g1_i3 Q6ZRF7 ZN818_HUMAN 1.00E-07 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Putative zinc finger protein 818 ZNF818P ZNF818 Homo sapiens (Human) TR26685_c0_g1_i2 Q5R9L9 POMP_PONAB 3.00E-28 GO:0005829; GO:0005783; GO:0005634; GO:0031090; GO:0043248; GO:0000502 cytosol; endoplasmic reticulum; nucleus; organelle membrane; proteasome assembly; proteasome complex IPR008012; Proteasome maturation protein (Proteassemblin) POMP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR26686_c0_g1_i1 Q0P4J6 CC90A_XENTR 1.00E-35 GO:0070509; GO:0051561; GO:0031305; GO:0006851 calcium ion import; elevation of mitochondrial calcium ion concentration; integral to mitochondrial inner membrane; mitochondrial calcium ion transport IPR024461; "Mitochondrial calcium uniporter regulator 1 (Coiled-coil domain-containing protein 90A, mitochondrial)" mcur1 ccdc90a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR26687_c0_g1_i1 P48465 ACT_CRYNV 2.00E-09 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; Actin CNAG_00483 Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) TR26688_c0_g2_i1 Q5U597 SKA2B_XENLA 1.00E-12 GO:0042113; GO:0005737; GO:0005543 B cell activation; cytoplasm; phospholipid binding IPR011993; IPR001849; IPR001452; Src kinase-associated phosphoprotein 2-B skap2-b Xenopus laevis (African clawed frog) TR26688_c0_g3_i1 Q5U597 SKA2B_XENLA 1.00E-12 GO:0042113; GO:0005737; GO:0005543 B cell activation; cytoplasm; phospholipid binding IPR011993; IPR001849; IPR001452; Src kinase-associated phosphoprotein 2-B skap2-b Xenopus laevis (African clawed frog) TR26689_c0_g1_i1 Q34946 ATP6_LUMTE 2.00E-33 GO:0015986; GO:0015078; GO:0016021; GO:0005743; GO:0045263 "ATP synthesis coupled proton transport; hydrogen ion transmembrane transporter activity; integral to membrane; mitochondrial inner membrane; proton-transporting ATP synthase complex, coupling factor F(o)" IPR000568; IPR023011; ATP synthase subunit a (F-ATPase protein 6) ATP6 Lumbricus terrestris (Common earthworm) TR26693_c1_g1_i1 Q5UNS9 COLL7_MIMIV 4.00E-08 GO:0005581; GO:0019012 collagen; virion IPR008160; Collagen-like protein 7 MIMI_L669 Acanthamoeba polyphaga mimivirus (APMV) TR26698_c6_g2_i1 Q9ULJ8 NEB1_HUMAN 8.00E-20 GO:0007015; GO:0019722; GO:0030054; GO:0030864; GO:0043197; GO:0030175; GO:0030426; GO:0031175; GO:0045202 P41220 actin filament organization; calcium-mediated signaling; cell junction; cortical actin cytoskeleton; dendritic spine; filopodium; growth cone; neuron projection development; synapse IPR001478; IPR001660; IPR013761; IPR011510; Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A) PPP1R9A KIAA1222 Homo sapiens (Human) TR26699_c0_g1_i2 P20645 MPRD_HUMAN 1.00E-06 GO:0009986; GO:0005768; GO:0008333; GO:0005887; GO:0005770; GO:0005765; GO:0005537; GO:0015578; GO:0006898; GO:0004888 cell surface; endosome; endosome to lysosome transport; integral to plasma membrane; late endosome; lysosomal membrane; mannose binding; mannose transmembrane transporter activity; receptor-mediated endocytosis; transmembrane signaling receptor activity IPR009011; IPR000296; Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46) M6PR MPR46 MPRD Homo sapiens (Human) TR26701_c2_g1_i1 Q54KA7 SECG_DICDI 2.00E-06 GO:0005086; GO:0031589; GO:0006935; GO:0005829; GO:0005764; GO:0005543; GO:0032012 ARF guanyl-nucleotide exchange factor activity; cell-substrate adhesion; chemotaxis; cytosol; lysosome; phospholipid binding; regulation of ARF protein signal transduction IPR002110; IPR020683; IPR011993; IPR001849; IPR023394; IPR000904; "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) TR26711_c0_g1_i1 Q801D8 MPRA_CYNNE 9.00E-40 GO:0030154; GO:0016021; GO:0007275; GO:0048477; GO:0005886; GO:0005496 cell differentiation; integral to membrane; multicellular organismal development; oogenesis; plasma membrane; steroid binding IPR004254; Membrane progestin receptor alpha (mPR alpha) (Membrane progesterone receptor) mpra Cynoscion nebulosus (Spotted seatrout) (Otolithus nebulosus) TR26711_c0_g1_i2 Q753H5 IZH1_ASHGO 2.00E-09 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR004254; ADIPOR-like receptor IZH1 IZH1 AFR337W Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR26711_c0_g1_i3 Q801D8 MPRA_CYNNE 1.00E-46 GO:0030154; GO:0016021; GO:0007275; GO:0048477; GO:0005886; GO:0005496 cell differentiation; integral to membrane; multicellular organismal development; oogenesis; plasma membrane; steroid binding IPR004254; Membrane progestin receptor alpha (mPR alpha) (Membrane progesterone receptor) mpra Cynoscion nebulosus (Spotted seatrout) (Otolithus nebulosus) TR26712_c0_g1_i1 A2A3V2 S2543_MOUSE 1.00E-76 GO:0016021; GO:0005743; GO:0005739; GO:0055085 integral to membrane; mitochondrial inner membrane; mitochondrion; transmembrane transport IPR002067; IPR018108; IPR023395; Solute carrier family 25 member 43 Slc25a43 Gm8 Mus musculus (Mouse) TR26716_c2_g1_i1 C1BXU5 UBL4A_ESOLU 6.00E-21 GO:0071818; GO:0071816; GO:0006810 BAT3 complex; tail-anchored membrane protein insertion into ER membrane; transport IPR019956; IPR019954; IPR000626; Ubiquitin-like protein 4A ubl4a Esox lucius (Northern pike) TR26720_c1_g1_i1 A8E4S7 MB213_DANRE 6.00E-06 IPR024810; Protein mab-21-like 3 mab21L3 si:ch211-246m4.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR26721_c1_g1_i1 Q8N5W9 F101B_HUMAN 7.00E-08 GO:0015629; GO:0030036; GO:0001837; GO:0031005 actin cytoskeleton; actin cytoskeleton organization; epithelial to mesenchymal transition; filamin binding IPR028215; Protein FAM101B FAM101B Homo sapiens (Human) TR26725_c0_g1_i3 Q5D0E6 DALD3_HUMAN 5.00E-42 GO:0005524; GO:0004814; GO:0006420 ATP binding; arginine-tRNA ligase activity; arginyl-tRNA aminoacylation IPR008909; IPR009080; DALR anticodon-binding domain-containing protein 3 DALRD3 Homo sapiens (Human) TR26726_c1_g2_i1 Q9H211 CDT1_HUMAN 1.00E-41 GO:0003677; GO:0006260; GO:0000076; GO:0005829; GO:0005654; GO:0030174; GO:0000083 Q99741; O75496; Q14566; P12004 DNA binding; DNA replication; DNA replication checkpoint; cytosol; nucleoplasm; regulation of DNA-dependent DNA replication initiation; regulation of transcription involved in G1/S transition of mitotic cell cycle IPR014939; DNA replication factor Cdt1 (Double parked homolog) (DUP) CDT1 Homo sapiens (Human) TR26726_c3_g1_i1 Q9I9A7 CDT1_XENLA 3.00E-11 GO:0003677; GO:0006260; GO:0007049; GO:0005634 O93352 DNA binding; DNA replication; cell cycle; nucleus IPR014939; DNA replication factor Cdt1 (XCDT1) cdt1 Xenopus laevis (African clawed frog) TR26727_c1_g1_i1 Q86VS3 IQCH_HUMAN 2.00E-38 IPR000048; IQ domain-containing protein H (Testis development protein NYD-SP5) IQCH Homo sapiens (Human) TR26728_c0_g1_i1 O00602 FCN1_HUMAN 5.00E-40 GO:0003823; GO:0005509; GO:0030246; GO:0005581; GO:0001867; GO:0005576; GO:0008228 Q2TS39 "antigen binding; calcium ion binding; carbohydrate binding; collagen; complement activation, lectin pathway; extracellular region; opsonization" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) FCN1 FCNM Homo sapiens (Human) TR26736_c1_g1_i1 Q99MI6 GIMA3_MOUSE 1.00E-11 GO:0005525; GO:0016021; GO:0033955; GO:0005741 GTP binding; integral to membrane; mitochondrial DNA inheritance; mitochondrial outer membrane IPR006703; IPR027417; GTPase IMAP family member 3 (Immunity-associated nucleotide 4 protein) (IAN-4) Gimap3 Ian4 Mus musculus (Mouse) TR26739_c0_g1_i1 Q640C5 DOPDB_XENLA 2.00E-08 GO:0033981; GO:0005737; GO:0042438 D-dopachrome decarboxylase activity; cytoplasm; melanin biosynthetic process IPR001398; IPR014347; D-dopachrome decarboxylase-B (EC 4.1.1.84) (D-dopachrome tautomerase-B) ddt-b Xenopus laevis (African clawed frog) TR26739_c0_g1_i2 Q18785 MIF2_CAEEL 7.00E-15 IPR001398; IPR019829; IPR014347; MIF-like protein mif-2 mif-2 C52E4.2 Caenorhabditis elegans TR26741_c1_g1_i1 Q9JKJ9 CP39A_MOUSE 9.00E-41 GO:0033782; GO:0006699; GO:0030573; GO:0006707; GO:0007586; GO:0005789; GO:0020037; GO:0043231; GO:0005506; GO:0008396; GO:0008387 24-hydroxycholesterol 7alpha-hydroxylase activity; bile acid biosynthetic process; bile acid catabolic process; cholesterol catabolic process; digestion; endoplasmic reticulum membrane; heme binding; intracellular membrane-bounded organelle; iron ion binding; oxysterol 7-alpha-hydroxylase activity; steroid 7-alpha-hydroxylase activity IPR001128; IPR024204; IPR002403; 24-hydroxycholesterol 7-alpha-hydroxylase (EC 1.14.13.99) (Cytochrome P450 39A1) (mCYP39A1) (Oxysterol 7-alpha-hydroxylase) Cyp39a1 Mus musculus (Mouse) TR26742_c4_g2_i1 Q5F3G0 RHG19_CHICK 1.00E-28 GO:0005096; GO:0005622; GO:0043547; GO:0007165 GTPase activator activity; intracellular; positive regulation of GTPase activity; signal transduction IPR008936; IPR000198; Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19) ARHGAP19 RCJMB04_18c11 Gallus gallus (Chicken) TR26744_c0_g2_i1 Q1LZH7 KANK2_BOVIN 3.00E-76 GO:0006915; GO:0005739; GO:2000134; GO:0008285; GO:0033147; GO:0043069; GO:0000122; GO:0006351 "apoptotic process; mitochondrion; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell proliferation; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of programmed cell death; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR002110; IPR020683; IPR021939; KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) KANK2 ANKRD25 Bos taurus (Bovine) TR26744_c0_g2_i2 Q14678 KANK1_HUMAN 3.00E-84 GO:0008013; GO:0005737; GO:0035024; GO:0030837; GO:0030336; GO:0046627; GO:2000393; GO:0010977; GO:1900028; GO:1900025; GO:0005634; GO:0030177; GO:0035413; GO:0090303; GO:2000114; GO:0006355; GO:0032587; GO:0006351 Q9UQB8; Q9UQB8-4; P35222; Q7Z4S6; P62258; P61981; Q04917; P27348 "beta-catenin binding; cytoplasm; negative regulation of Rho protein signal transduction; negative regulation of actin filament polymerization; negative regulation of cell migration; negative regulation of insulin receptor signaling pathway; negative regulation of lamellipodium morphogenesis; negative regulation of neuron projection development; negative regulation of ruffle assembly; negative regulation of substrate adhesion-dependent cell spreading; nucleus; positive regulation of Wnt receptor signaling pathway; positive regulation of catenin import into nucleus; positive regulation of wound healing; regulation of establishment of cell polarity; regulation of transcription, DNA-dependent; ruffle membrane; transcription, DNA-dependent" IPR002110; IPR020683; IPR021939; KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) KANK1 ANKRD15 KANK KIAA0172 Homo sapiens (Human) TR26745_c1_g1_i1 Q1PRL4 LIN41_CHICK 2.00E-06 GO:0000082; GO:0000932; GO:0008543; GO:0035198; GO:0010586; GO:0035278; GO:0001843; GO:0021915; GO:2000637; GO:0051865; GO:0060964; GO:2000177; GO:0072089; GO:0004842; GO:0008270 G1/S transition of mitotic cell cycle; cytoplasmic mRNA processing body; fibroblast growth factor receptor signaling pathway; miRNA binding; miRNA metabolic process; negative regulation of translation involved in gene silencing by miRNA; neural tube closure; neural tube development; positive regulation of gene silencing by miRNA; protein autoubiquitination; regulation of gene silencing by miRNA; regulation of neural precursor cell proliferation; stem cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Gallus gallus (Chicken) TR26748_c0_g2_i1 Q923Z0 GPC5B_MOUSE 4.00E-06 GO:0004930; GO:0005794; GO:0070062; GO:0016021; GO:0007626; GO:0005730; GO:0005886; GO:0010976 G-protein coupled receptor activity; Golgi apparatus; extracellular vesicular exosome; integral to membrane; locomotory behavior; nucleolus; plasma membrane; positive regulation of neuron projection development IPR017978; G-protein coupled receptor family C group 5 member B (Retinoic acid-induced gene 2 protein) (RAIG-2) Gprc5b Raig2 Mus musculus (Mouse) TR26750_c2_g3_i1 P56695 WFS1_MOUSE 1.00E-42 GO:0051117; GO:0030433; GO:0033613; GO:0030425; GO:0032469; GO:0030968; GO:0042593; GO:0030176; GO:0001822; GO:1902236; GO:0043524; GO:0043433; GO:2000675; GO:0070845; GO:0051928; GO:0045927; GO:0031398; GO:0045862; GO:0050821; GO:0051726; GO:0003091; GO:0007605; GO:0005215; GO:0031625; GO:0007601 ATPase binding; ER-associated protein catabolic process; activating transcription factor binding; dendrite; endoplasmic reticulum calcium ion homeostasis; endoplasmic reticulum unfolded protein response; glucose homeostasis; integral to endoplasmic reticulum membrane; kidney development; negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; negative regulation of neuron apoptotic process; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of type B pancreatic cell apoptotic process; polyubiquitinated misfolded protein transport; positive regulation of calcium ion transport; positive regulation of growth; positive regulation of protein ubiquitination; positive regulation of proteolysis; protein stabilization; regulation of cell cycle; renal water homeostasis; sensory perception of sound; transporter activity; ubiquitin protein ligase binding; visual perception IPR026208; IPR026209; Wolframin Wfs1 Mus musculus (Mouse) TR2676_c0_g1_i1 P97675 ENPP3_RAT 1.00E-20 GO:0035529; GO:0009986; GO:0005576; GO:0006955; GO:0016021; GO:0046872; GO:0003676; GO:0009143; GO:0047429; GO:0004551; GO:0048471; GO:0004528; GO:0030247; GO:0051150; GO:0005044 NADH pyrophosphatase activity; cell surface; extracellular region; immune response; integral to membrane; metal ion binding; nucleic acid binding; nucleoside triphosphate catabolic process; nucleoside-triphosphate diphosphatase activity; nucleotide diphosphatase activity; perinuclear region of cytoplasm; phosphodiesterase I activity; polysaccharide binding; regulation of smooth muscle cell differentiation; scavenger receptor activity IPR017849; IPR017850; IPR001604; IPR024873; IPR020821; IPR002591; IPR001212; Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (E-NPP 3) (B10) (Phosphodiesterase I beta) (PD-Ibeta) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (RB13-6 antigen) (CD antigen CD203c) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9)] Enpp3 Pdnp3 Rattus norvegicus (Rat) TR26764_c4_g1_i1 Q6UB98 ANR12_HUMAN 2.00E-15 GO:0005737; GO:0005634 cytoplasm; nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) ANKRD12 ANCO2 KIAA0874 Homo sapiens (Human) TR26764_c5_g1_i1 P42118 TDT_XENLA 3.00E-19 GO:0003677; GO:0006304; GO:0003912; GO:0003887; GO:0046872; GO:0005634 DNA binding; DNA modification; DNA nucleotidylexotransferase activity; DNA-directed DNA polymerase activity; metal ion binding; nucleus IPR001357; IPR002054; IPR019843; IPR010996; IPR028207; IPR018944; IPR022312; IPR027421; IPR001726; DNA nucleotidylexotransferase (EC 2.7.7.31) (Terminal addition enzyme) (Terminal deoxynucleotidyltransferase) (TDT) (Terminal transferase) dntt tdt Xenopus laevis (African clawed frog) TR26764_c6_g1_i1 Q7ZT11 ANKR1_CHICK 6.00E-07 GO:0005634 nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) ANKRD1 CARP Gallus gallus (Chicken) TR26764_c7_g1_i1 Q9NP87 DPOLM_HUMAN 1.00E-19 GO:0030183; GO:0003677; GO:0006310; GO:0006281; GO:0003887; GO:0046872; GO:0005634; GO:0016446 B cell differentiation; DNA binding; DNA recombination; DNA repair; DNA-directed DNA polymerase activity; metal ion binding; nucleus; somatic hypermutation of immunoglobulin genes IPR001357; IPR002054; IPR027249; IPR019843; IPR010996; IPR028207; IPR018944; IPR022312; IPR027421; IPR001726; DNA-directed DNA/RNA polymerase mu (Pol Mu) (EC 2.7.7.7) (Terminal transferase) POLM polmu Homo sapiens (Human) TR26764_c8_g3_i1 Q9QZH2 BARD1_RAT 8.00E-32 GO:0031436; GO:0006281; GO:0005737; GO:0016874; GO:0043066; GO:0046826; GO:0043065; GO:0085020; GO:0042803; GO:0042325; GO:0007283; GO:0008270 BRCA1-BARD1 complex; DNA repair; cytoplasm; ligase activity; negative regulation of apoptotic process; negative regulation of protein export from nucleus; positive regulation of apoptotic process; protein K6-linked ubiquitination; protein homodimerization activity; regulation of phosphorylation; spermatogenesis; zinc ion binding IPR002110; IPR020683; IPR001357; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. BRCA1-associated RING domain protein 1 (BARD-1) (EC 6.3.2.-) Bard1 Rattus norvegicus (Rat) TR26766_c0_g1_i1 Q8IW92 GLBL2_HUMAN 3.00E-76 GO:0004565; GO:0005975; GO:0005576 beta-galactosidase activity; carbohydrate metabolic process; extracellular region IPR026283; IPR008979; IPR019801; IPR013781; IPR001944; IPR017853; Beta-galactosidase-1-like protein 2 (EC 3.2.1.-) GLB1L2 MSTP014 UNQ210/PRO236 Homo sapiens (Human) TR26766_c1_g1_i1 Q3UPY5 GLBL2_MOUSE 1.00E-76 GO:0004565; GO:0005975; GO:0005576 beta-galactosidase activity; carbohydrate metabolic process; extracellular region IPR026283; IPR008979; IPR019801; IPR013781; IPR001944; IPR017853; Beta-galactosidase-1-like protein 2 (EC 3.2.1.-) Glb1l2 Mus musculus (Mouse) TR26771_c1_g1_i1 Q4R8G4 POC5_MACFA 6.00E-25 GO:0007049; GO:0005814 cell cycle; centriole Centrosomal protein POC5 (Protein of centriole 5) POC5 QtsA-12524 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR26771_c3_g1_i1 Q4V891 POC5_RAT 1.00E-32 GO:0007049; GO:0005814 cell cycle; centriole Centrosomal protein POC5 (Protein of centriole 5) Poc5 Rattus norvegicus (Rat) TR26774_c0_g1_i1 P34611 NCL1_CAEEL 2.00E-29 GO:0005737; GO:0090071; GO:0008270 Q22227; O45521; Q22174 cytoplasm; negative regulation of ribosome biogenesis; zinc ion binding IPR011042; IPR003649; IPR001258; IPR013017; IPR000315; B-box type zinc finger protein ncl-1 ncl-1 ZK112.2 Caenorhabditis elegans TR26784_c7_g1_i2 Q0P4Y8 LMF2_XENTR 1.00E-53 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR009613; Lipase maturation factor 2 lmf2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR26784_c8_g1_i1 Q13489 BIRC3_HUMAN 1.00E-06 GO:0038061; GO:0035666; GO:0006915; GO:0007166; GO:0005829; GO:0045087; GO:0070266; GO:0043066; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0043123; GO:0039535; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0034138; GO:0034142; GO:0004842; GO:0008270 Q13546; O43353; Q9Y572; P57078; Q12933 NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; apoptotic process; cell surface receptor signaling pathway; cytosol; innate immune response; necroptosis; negative regulation of apoptotic process; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of RIG-I signaling pathway; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Apoptosis inhibitor 2) (API2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (IAP-1) (hIAP-1) (hIAP1) (RING finger protein 49) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 IAP1 MIHC RNF49 Homo sapiens (Human) TR26785_c2_g1_i1 Q60778 IKBB_MOUSE 2.00E-14 GO:0005737; GO:0005634 Q9Z1K6; Q04207 cytoplasm; nucleus IPR002110; IPR020683; NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) Nfkbib Ikbb Mus musculus (Mouse) TR26785_c2_g2_i1 P20749 BCL3_HUMAN 1.00E-37 GO:0032996; GO:0033257; GO:0003677; GO:0030330; GO:0007249; GO:0042088; GO:0045064; GO:0019730; GO:0005737; GO:0042742; GO:0042832; GO:0030198; GO:0002268; GO:0002467; GO:0002455; GO:0042771; GO:0051457; GO:0002315; GO:0043066; GO:0045415; GO:0045892; GO:0042536; GO:0005634; GO:0048471; GO:0032729; GO:0045082; GO:0045944; GO:0045893; GO:0045727; GO:0030674; GO:0000060; GO:0051101; GO:0042345; GO:0010225; GO:0009615; GO:0003700; GO:0048536; GO:0006351 O95999; P56545; P06239 "Bcl3-Bcl10 complex; Bcl3/NF-kappaB2 complex; DNA binding; DNA damage response, signal transduction by p53 class mediator; I-kappaB kinase/NF-kappaB cascade; T-helper 1 type immune response; T-helper 2 cell differentiation; antimicrobial humoral response; cytoplasm; defense response to bacterium; defense response to protozoan; extracellular matrix organization; follicular dendritic cell differentiation; germinal center formation; humoral immune response mediated by circulating immunoglobulin; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; maintenance of protein location in nucleus; marginal zone B cell differentiation; negative regulation of apoptotic process; negative regulation of interleukin-8 biosynthetic process; negative regulation of transcription, DNA-dependent; negative regulation of tumor necrosis factor biosynthetic process; nucleus; perinuclear region of cytoplasm; positive regulation of interferon-gamma production; positive regulation of interleukin-10 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of translation; protein binding, bridging; protein import into nucleus, translocation; regulation of DNA binding; regulation of NF-kappaB import into nucleus; response to UV-C; response to virus; sequence-specific DNA binding transcription factor activity; spleen development; transcription, DNA-dependent" IPR002110; IPR020683; B-cell lymphoma 3 protein (BCL-3) (Proto-oncogene BCL3) BCL3 BCL4 D19S37 Homo sapiens (Human) TR26787_c0_g1_i3 P22897 MRC1_HUMAN 5.00E-07 GO:0010008; GO:0005887; GO:0005537; GO:0004872; GO:0006898 endosome membrane; integral to plasma membrane; mannose binding; receptor activity; receptor-mediated endocytosis IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206) MRC1 CLEC13D CLEC13DL MRC1L1 Homo sapiens (Human) TR26790_c0_g1_i1 P96576 YDAC_BACSU 9.00E-12 GO:0008168 methyltransferase activity IPR013216; Uncharacterized methyltransferase YdaC (EC 2.1.1.-) ydaC BSU04180 Bacillus subtilis (strain 168) TR26792_c1_g2_i1 Q9ULD5 ZN777_HUMAN 5.00E-07 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR022137; IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 777 ZNF777 KIAA1285 Homo sapiens (Human) TR26794_c1_g1_i1 Q9BWD1 THIC_HUMAN 2.00E-175 GO:0003985; GO:0006629; GO:0005739; GO:0005730 acetyl-CoA C-acetyltransferase activity; lipid metabolic process; mitochondrion; nucleolus IPR002155; IPR016039; IPR016038; IPR020610; IPR020617; IPR020613; IPR020616; "Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Acetyl-CoA transferase-like protein) (Cytosolic acetoacetyl-CoA thiolase)" ACAT2 ACTL Homo sapiens (Human) TR26797_c0_g3_i1 Q6NZQ0 CP093_MOUSE 2.00E-06 Coiled-coil domain-containing protein C16orf93 homolog Gm166 Mus musculus (Mouse) TR26797_c0_g3_i2 Q8CDT7 CJ107_MOUSE 9.00E-33 Uncharacterized protein C10orf107 homolog Mus musculus (Mouse) TR26801_c0_g1_i1 Q8IZ57 NRSN1_HUMAN 9.00E-17 GO:0030426; GO:0016021; GO:0007399; GO:0043025; GO:0030133 growth cone; integral to membrane; nervous system development; neuronal cell body; transport vesicle Neurensin-1 (Neuro-p24) (Vesicular membrane protein of 24 kDa) (Vesicular membrane protein p24) NRSN1 VMP Homo sapiens (Human) TR26807_c0_g1_i1 Q6PCL9 PAPOG_MOUSE 3.00E-45 GO:0005524; GO:0003723; GO:0006378; GO:0046872; GO:0005634; GO:0004652 ATP binding; RNA binding; mRNA polyadenylation; metal ion binding; nucleus; polynucleotide adenylyltransferase activity IPR002934; IPR011068; IPR007012; IPR007010; IPR014492; Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) Papolg Mus musculus (Mouse) TR26807_c1_g2_i1 Q9BWT3 PAPOG_HUMAN 2.00E-143 GO:0005524; GO:0003723; GO:0006378; GO:0046872; GO:0005634; GO:0004652 ATP binding; RNA binding; mRNA polyadenylation; metal ion binding; nucleus; polynucleotide adenylyltransferase activity IPR002934; IPR011068; IPR007012; IPR007010; IPR014492; Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) PAPOLG PAP2 PAPG Homo sapiens (Human) TR26809_c1_g1_i1 Q9V6X7 OFUT1_DROME 6.00E-55 GO:0005112; GO:0007219; GO:0016266; GO:0016337; GO:0031410; GO:0009790; GO:0006897; GO:0005783; GO:0006004; GO:0046331; GO:0045746; GO:0046922; GO:0030163; GO:0006355 Q9VXE7; Q9VDI1 "Notch binding; Notch signaling pathway; O-glycan processing; cell-cell adhesion; cytoplasmic vesicle; embryo development; endocytosis; endoplasmic reticulum; fucose metabolic process; lateral inhibition; negative regulation of Notch signaling pathway; peptide-O-fucosyltransferase activity; protein catabolic process; regulation of transcription, DNA-dependent" IPR019378; Protein modification; protein glycosylation. GDP-fucose protein O-fucosyltransferase 1 (EC 2.4.1.221) (Neurotic protein) (Peptide-O-fucosyltransferase 1) (O-FucT-1) O-fut1 nti CG12366 Drosophila melanogaster (Fruit fly) TR26809_c1_g2_i1 P83337 OFUT1_CRIGR 3.00E-14 GO:0007219; GO:0005783; GO:0006004; GO:0046922 Notch signaling pathway; endoplasmic reticulum; fucose metabolic process; peptide-O-fucosyltransferase activity IPR019378; Protein modification; protein glycosylation. GDP-fucose protein O-fucosyltransferase 1 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 1) (O-FucT-1) POFUT1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR26813_c1_g1_i1 Q613L4 HDA4_CAEBR 1.00E-16 GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0070932; GO:0070933; GO:0005634; GO:0006355; GO:0006351 "NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone H3 deacetylation; histone H4 deacetylation; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000286; IPR023801; Histone deacetylase 4 (EC 3.5.1.98) hda-4 CBG16328 Caenorhabditis briggsae TR26813_c5_g1_i1 Q6P3E7 HDA10_MOUSE 2.00E-39 GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0005737; GO:0070932; GO:0070933; GO:0004407; GO:0000118; GO:0000122; GO:0014003; GO:0006351 "NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); cytoplasm; histone H3 deacetylation; histone H4 deacetylation; histone deacetylase activity; histone deacetylase complex; negative regulation of transcription from RNA polymerase II promoter; oligodendrocyte development; transcription, DNA-dependent" IPR000286; IPR023801; Histone deacetylase 10 (HD10) (EC 3.5.1.98) Hdac10 Mus musculus (Mouse) TR26817_c1_g1_i1 P06734 FCER2_HUMAN 2.00E-07 GO:0007219; GO:0030246; GO:0009897; GO:0005576; GO:0005887; GO:0005178; GO:0046872; GO:0002925; GO:0051712; GO:0051000; GO:0051770 Notch signaling pathway; carbohydrate binding; external side of plasma membrane; extracellular region; integral to plasma membrane; integrin binding; metal ion binding; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of killing of cells of other organism; positive regulation of nitric-oxide synthase activity; positive regulation of nitric-oxide synthase biosynthetic process IPR001304; IPR016186; IPR018378; IPR016187; Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form] FCER2 CD23A CLEC4J FCE2 IGEBF Homo sapiens (Human) TR26817_c1_g1_i2 Q9UBG0 MRC2_HUMAN 6.00E-09 GO:0030246; GO:0006897; GO:0016021 carbohydrate binding; endocytosis; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; C-type mannose receptor 2 (C-type lectin domain family 13 member E) (Endocytic receptor 180) (Macrophage mannose receptor 2) (Urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (Urokinase receptor-associated protein) (CD antigen CD280) MRC2 CLEC13E ENDO180 KIAA0709 UPARAP Homo sapiens (Human) TR26819_c0_g1_i1 Q24498 RY44_DROME 3.00E-84 GO:0005509; GO:0006874; GO:0016021; GO:0005875; GO:0007275; GO:0006936; GO:0035206; GO:0072347; GO:0005219; GO:0033017 calcium ion binding; cellular calcium ion homeostasis; integral to membrane; microtubule associated complex; multicellular organismal development; muscle contraction; regulation of hemocyte proliferation; response to anesthetic; ryanodine-sensitive calcium-release channel activity; sarcoplasmic reticulum membrane IPR001870; IPR000699; IPR008985; IPR011992; IPR014821; IPR005821; IPR016093; IPR013662; IPR013333; IPR003032; IPR015925; IPR009460; IPR018355; IPR003877; Ryanodine receptor 44F Rya-r44F dry RyR CG10844 Drosophila melanogaster (Fruit fly) TR26821_c0_g1_i1 Q10162 YAU6_SCHPO 3.00E-30 GO:0005829; GO:0005634; GO:0016435 cytosol; nucleus; rRNA (guanine) methyltransferase activity IPR013216; IPR022238; Putative methyltransferase C26A3.06 SPAC26A3.06 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR26822_c1_g1_i1 P00732 CBPB1_BOVIN 5.00E-47 GO:0005576; GO:0004181; GO:0006508; GO:0008270 extracellular region; metallocarboxypeptidase activity; proteolysis; zinc ion binding IPR000834; IPR003146; IPR009020; Carboxypeptidase B (EC 3.4.17.2) CPB1 CPB Bos taurus (Bovine) TR26823_c0_g1_i1 P30532 ACHA5_HUMAN 2.00E-22 GO:0015464; GO:0004889; GO:0005892; GO:0035095; GO:0030054; GO:0045211 acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; behavioral response to nicotine; cell junction; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 NACHRA5 Homo sapiens (Human) TR26823_c0_g1_i2 Q9JLB5 ACH10_RAT 3.00E-30 GO:0004889; GO:0030424; GO:0005262; GO:0030054; GO:0007204; GO:0016021; GO:0043204; GO:0045211; GO:0007271 "acetylcholine-activated cation-selective channel activity; axon; calcium channel activity; cell junction; elevation of cytosolic calcium ion concentration; integral to membrane; perikaryon; postsynaptic membrane; synaptic transmission, cholinergic" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) Chrna10 Rattus norvegicus (Rat) TR26829_c1_g2_i1 P51156 RAB26_RAT 4.00E-101 GO:0019002; GO:0005525; GO:0003924; GO:0000139; GO:0043001; GO:0035272; GO:0031226; GO:0045055; GO:0017157; GO:0030667; GO:0007264; GO:0030658 GMP binding; GTP binding; GTPase activity; Golgi membrane; Golgi to plasma membrane protein transport; exocrine system development; intrinsic to plasma membrane; regulated secretory pathway; regulation of exocytosis; secretory granule membrane; small GTPase mediated signal transduction; transport vesicle membrane IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-26 Rab26 Rattus norvegicus (Rat) TR26830_c0_g2_i1 Q9Z2A0 PDPK1_MOUSE 0 GO:0004676; GO:0005524; GO:0032148; GO:0032869; GO:0016023; GO:0005829; GO:0097191; GO:0005925; GO:0048041; GO:0006972; GO:0035556; GO:0010667; GO:0006469; GO:0034122; GO:0030512; GO:0005634; GO:0018107; GO:0005886; GO:0090004; GO:0043122; GO:0010594; GO:0043304; GO:0006355; GO:0007165; GO:0006351; GO:0003323 "3-phosphoinositide-dependent protein kinase activity; ATP binding; activation of protein kinase B activity; cellular response to insulin stimulus; cytoplasmic membrane-bounded vesicle; cytosol; extrinsic apoptotic signaling pathway; focal adhesion; focal adhesion assembly; hyperosmotic response; intracellular signal transduction; negative regulation of cardiac muscle cell apoptotic process; negative regulation of protein kinase activity; negative regulation of toll-like receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; nucleus; peptidyl-threonine phosphorylation; plasma membrane; positive regulation of establishment of protein localization to plasma membrane; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of endothelial cell migration; regulation of mast cell degranulation; regulation of transcription, DNA-dependent; signal transduction; transcription, DNA-dependent; type B pancreatic cell development" IPR011009; IPR011993; IPR000719; IPR017441; IPR002290; IPR008271; 3-phosphoinositide-dependent protein kinase 1 (mPDK1) (EC 2.7.11.1) Pdpk1 Pdk1 Mus musculus (Mouse) TR26836_c5_g1_i1 Q9NZJ4 SACS_HUMAN 3.00E-07 GO:0005524; GO:0030424; GO:0070852; GO:0008219; GO:0051087; GO:0030425; GO:0005739; GO:0090084; GO:0005634; GO:0006457 ATP binding; axon; cell body fiber; cell death; chaperone binding; dendrite; mitochondrion; negative regulation of inclusion body assembly; nucleus; protein folding IPR001623; IPR003594; IPR007842; IPR000626; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) TR26837_c0_g1_i1 Q8TDG4 HELQ_HUMAN 2.00E-38 GO:0005524; GO:0008026; GO:0003676; GO:0005730 ATP binding; ATP-dependent helicase activity; nucleic acid binding; nucleolus IPR011545; IPR014001; IPR001650; IPR027417; Helicase POLQ-like (EC 3.6.4.12) (Mus308-like helicase) (POLQ-like helicase) HELQ HEL308 Homo sapiens (Human) TR26840_c0_g1_i1 P49395 RS3A_APLCA 2.00E-148 GO:0022627; GO:0003735; GO:0006412 cytosolic small ribosomal subunit; structural constituent of ribosome; translation IPR027500; IPR001593; IPR018281; 40S ribosomal protein S3a (Lysine-rich protein KRP-A) RPS3A KRP-A Aplysia californica (California sea hare) TR26843_c0_g1_i1 B0JZ65 LRWD1_XENTR 8.00E-62 GO:0006260; GO:0005721; GO:0003682; GO:0016568; GO:0006325; GO:0005737; GO:0071169; GO:0008327; GO:0035064; GO:0005815; GO:0005664; GO:0031933 DNA replication; centromeric heterochromatin; chromatin binding; chromatin modification; chromatin organization; cytoplasm; establishment of protein localization to chromatin; methyl-CpG binding; methylated histone residue binding; microtubule organizing center; nuclear origin of replication recognition complex; telomeric heterochromatin IPR001611; IPR003591; IPR015943; IPR001680; IPR019775; IPR017986; Leucine-rich repeat and WD repeat-containing protein 1 (ORC-associated protein) (ORCA) (Origin recognition complex-associated protein) lrwd1 orca Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR26847_c2_g1_i1 O14807 RASM_HUMAN 6.00E-77 GO:0005525; GO:0003924; GO:0007265; GO:0030036; GO:0007517; GO:0005886 GTP binding; GTPase activity; Ras protein signal transduction; actin cytoskeleton organization; muscle organ development; plasma membrane IPR027417; IPR005225; IPR001806; IPR020849; Ras-related protein M-Ras (Ras-related protein R-Ras3) MRAS RRAS3 Homo sapiens (Human) TR26848_c0_g1_i1 Q32P85 DLRB2_BOVIN 9.00E-49 GO:0005868; GO:0005874; GO:0003774; GO:0006810 cytoplasmic dynein complex; microtubule; motor activity; transport IPR004942; IPR016561; "Dynein light chain roadblock-type 2 (Dynein light chain 2B, cytoplasmic)" DYNLRB2 DNLC2B Bos taurus (Bovine) TR26850_c1_g2_i1 A4IIC5 S39A3_XENTR 2.00E-39 GO:0016021; GO:0046873; GO:0006829 integral to membrane; metal ion transmembrane transporter activity; zinc ion transport IPR003689; Zinc transporter ZIP3 (Solute carrier family 39 member 3) (Zrt- and Irt-like protein 3) (ZIP-3) slc39a3 zip3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR26858_c0_g1_i1 Q6T269 IVBI3_BITGA 8.00E-24 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Protease inhibitor bitisilin-3 (Two-Kunitz protease inhibitor) (Fragment) Bitis gabonica (Gaboon adder) (Gaboon viper) TR26858_c0_g1_i2 Q6T269 IVBI3_BITGA 2.00E-22 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Protease inhibitor bitisilin-3 (Two-Kunitz protease inhibitor) (Fragment) Bitis gabonica (Gaboon adder) (Gaboon viper) TR26860_c1_g1_i2 Q5ZIN1 NUDC_CHICK 8.00E-83 GO:0051301; GO:0005737; GO:0005874; GO:0007067 cell division; cytoplasm; microtubule; mitosis IPR007052; IPR008978; IPR025934; Nuclear migration protein nudC (Nuclear distribution protein C homolog) NUDC RCJMB04_24m10 Gallus gallus (Chicken) TR26862_c0_g1_i1 P86861 FND_MYTCA 5.00E-131 GO:0005576 extracellular region IPR003961; IPR013783; Fibronectin type III domain-containing protein (Fibronectin-like protein) (Fragment) Mytilus californianus (California mussel) TR26862_c0_g1_i2 P86861 FND_MYTCA 5.00E-131 GO:0005576 extracellular region IPR003961; IPR013783; Fibronectin type III domain-containing protein (Fibronectin-like protein) (Fragment) Mytilus californianus (California mussel) TR26864_c0_g1_i1 Q9BXJ4 C1QT3_HUMAN 1.00E-09 GO:0035356; GO:0005581; GO:0005615; GO:0045444; GO:0042593; GO:0042347; GO:0010629; GO:0045721; GO:0050728; GO:1900165; GO:0071638; GO:0070374; GO:0070165; GO:0050715; GO:0051897; GO:0070206 cellular triglyceride homeostasis; collagen; extracellular space; fat cell differentiation; glucose homeostasis; negative regulation of NF-kappaB import into nucleus; negative regulation of gene expression; negative regulation of gluconeogenesis; negative regulation of inflammatory response; negative regulation of interleukin-6 secretion; negative regulation of monocyte chemotactic protein-1 production; positive regulation of ERK1 and ERK2 cascade; positive regulation of adiponectin secretion; positive regulation of cytokine secretion; positive regulation of protein kinase B signaling cascade; protein trimerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) TR26866_c0_g1_i1 A6NJW4 LRR3C_HUMAN 6.00E-11 GO:0016021 integral to membrane IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing protein 3C LRRC3C Homo sapiens (Human) TR26872_c1_g1_i1 Q9W770 SPON1_CHICK 5.00E-15 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR002861; IPR009465; IPR000884; Spondin-1 (F-spondin) SPON1 Gallus gallus (Chicken) TR26872_c1_g1_i2 A6NMZ7 CO6A6_HUMAN 3.00E-11 GO:0007155; GO:0005581; GO:0030574; GO:0031012; GO:0022617; GO:0005576 cell adhesion; collagen; collagen catabolic process; extracellular matrix; extracellular matrix disassembly; extracellular region IPR008160; IPR002035; Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) TR26874_c0_g1_i1 Q5I0B9 ATG16_XENTR 2.00E-115 GO:0006914; GO:0005737; GO:0016020; GO:0015031 autophagy; cytoplasm; membrane; protein transport IPR013923; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Autophagy-related protein 16 (APG16-like 1) atg16 apg16l TEgg115a02.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR26877_c0_g1_i1 P35064 H2AX_TETTS 2.00E-46 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR002119; Histone H2AX (Histone H2A.1) (H2A1) (Histone H2A.X) HTA1 TTHERM_00790790 Tetrahymena thermophila (strain SB210) TR26879_c3_g2_i2 Q7TNJ0 DCSTP_MOUSE 3.00E-07 GO:0009986; GO:0071353; GO:0036006; GO:0071356; GO:0033116; GO:0010008; GO:0030176; GO:0005887; GO:0061025; GO:0043011; GO:0030308; GO:0072675; GO:0045780; GO:0034241; GO:0045657 cell surface; cellular response to interleukin-4; cellular response to macrophage colony-stimulating factor stimulus; cellular response to tumor necrosis factor; endoplasmic reticulum-Golgi intermediate compartment membrane; endosome membrane; integral to endoplasmic reticulum membrane; integral to plasma membrane; membrane fusion; myeloid dendritic cell differentiation; negative regulation of cell growth; osteoclast fusion; positive regulation of bone resorption; positive regulation of macrophage fusion; positive regulation of monocyte differentiation IPR012858; Dendritic cell-specific transmembrane protein (DC-STAMP) (mDC-STAMP) (Dendrocyte-expressed seven transmembrane protein) (Transmembrane 7 superfamily member 4) Dcstamp Tm7sf4 Mus musculus (Mouse) TR26879_c6_g1_i1 Q5T1A1 DCST2_HUMAN 8.00E-11 GO:0016021 integral to membrane IPR012858; DC-STAMP domain-containing protein 2 DCST2 Homo sapiens (Human) TR26881_c0_g1_i1 Q9Z139 ROR1_MOUSE 3.00E-18 GO:0005524; GO:0005887; GO:0004714; GO:0007169 ATP binding; integral to plasma membrane; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR020067; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000001; IPR013806; IPR018056; IPR000719; IPR001245; IPR008266; IPR020635; IPR016247; "Tyrosine-protein kinase transmembrane receptor ROR1 (mROR1) (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1)" Ror1 Ntrkr1 Mus musculus (Mouse) TR26881_c0_g2_i1 Q01177 PLMN_RAT 2.00E-39 GO:0006915; GO:0007596; GO:0004175; GO:0022617; GO:0005615; GO:0031232; GO:0042730; GO:0043231; GO:0060716; GO:0071674; GO:0046716; GO:0045445; GO:0010812; GO:0051918; GO:0005886; GO:0051919; GO:0051603; GO:0004252; GO:0042246; GO:0048771; GO:0060707 apoptotic process; blood coagulation; endopeptidase activity; extracellular matrix disassembly; extracellular space; extrinsic to external side of plasma membrane; fibrinolysis; intracellular membrane-bounded organelle; labyrinthine layer blood vessel development; mononuclear cell migration; muscle cell cellular homeostasis; myoblast differentiation; negative regulation of cell-substrate adhesion; negative regulation of fibrinolysis; plasma membrane; positive regulation of fibrinolysis; proteolysis involved in cellular protein catabolic process; serine-type endopeptidase activity; tissue regeneration; tissue remodeling; trophoblast giant cell differentiation IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]" Plg Rattus norvegicus (Rat) TR26882_c1_g1_i1 Q3TIX9 SNUT2_MOUSE 0 GO:0008380; GO:0007049; GO:0051301; GO:0006397; GO:0005681; GO:0004221; GO:0006511; GO:0008270 RNA splicing; cell cycle; cell division; mRNA processing; spliceosomal complex; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; zinc ion binding IPR001394; IPR015880; IPR013083; IPR001607; U4/U6.U5 tri-snRNP-associated protein 2 (Inactive ubiquitin-specific peptidase 39) Usp39 Mus musculus (Mouse) TR26883_c3_g1_i1 Q96BV0 ZN775_HUMAN 5.00E-15 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 775 ZNF775 Homo sapiens (Human) TR26883_c3_g1_i2 Q96N95 ZN396_HUMAN 1.00E-14 GO:0003677; GO:0005737; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; cytoplasm; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein 396 (Zinc finger and SCAN domain-containing protein 14) ZNF396 ZSCAN14 Homo sapiens (Human) TR26883_c3_g2_i1 Q8BGS3 ZKSC1_MOUSE 4.00E-31 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein with KRAB and SCAN domains 1 Zkscan1 Mus musculus (Mouse) TR26883_c3_g2_i2 Q969J2 ZKSC4_HUMAN 7.00E-24 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein with KRAB and SCAN domains 4 (P373c6.1) (Zinc finger protein 307) (Zinc finger protein 427) ZKSCAN4 ZNF307 ZNF427 Homo sapiens (Human) TR26884_c0_g1_i1 Q9ZMM2 HTPG_HELPJ 7.00E-13 GO:0005524; GO:0005737; GO:0006457; GO:0006950 ATP binding; cytoplasm; protein folding; response to stress IPR003594; IPR019805; IPR001404; IPR020575; IPR027058; IPR020568; Chaperone protein HtpG (Heat shock protein HtpG) (High temperature protein G) htpG jhp_0196 Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) TR26884_c2_g1_i1 Q04619 HS90B_CHICK 3.00E-103 GO:0005524; GO:0005829; GO:0042470; GO:0006457; GO:0006950 ATP binding; cytosol; melanosome; protein folding; response to stress IPR003594; IPR019805; IPR001404; IPR020575; IPR020568; Heat shock cognate protein HSP 90-beta HSP90AB1 HSPCB Gallus gallus (Chicken) TR26889_c1_g1_i3 Q9BSD7 NTPCR_HUMAN 3.00E-57 GO:0005524; GO:0017111; GO:0016740 ATP binding; nucleoside-triphosphatase activity; transferase activity IPR003593; IPR004948; IPR027417; Cancer-related nucleoside-triphosphatase (NTPase) (EC 3.6.1.15) (Nucleoside triphosphate phosphohydrolase) NTPCR C1orf57 Homo sapiens (Human) TR26892_c0_g1_i1 Q28CQ4 UBC9_XENTR 8.00E-100 GO:0005524; GO:0019789; GO:0051301; GO:0007059; GO:0007067; GO:0005634; GO:0016925 ATP binding; SUMO ligase activity; cell division; chromosome segregation; mitosis; nucleus; protein sumoylation IPR027230; IPR000608; IPR023313; IPR016135; Protein modification; protein sumoylation. SUMO-conjugating enzyme UBC9 (EC 6.3.2.-) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) ube2i ubc9 ubce9 TEgg019l14.1 TEgg096h05.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR26893_c0_g1_i1 Q52KB5 ZBT24_DANRE 3.00E-14 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017956; IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450) zbtb24 zfp450 zgc:194556 Danio rerio (Zebrafish) (Brachydanio rerio) TR26893_c0_g1_i2 Q3V080 ZN583_MOUSE 2.00E-15 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 583 Znf583 Zfp583 Mus musculus (Mouse) TR26895_c2_g2_i1 P58242 ASM3B_MOUSE 7.00E-30 GO:0005615; GO:0016798; GO:0006685; GO:0004767 "extracellular space; hydrolase activity, acting on glycosyl bonds; sphingomyelin catabolic process; sphingomyelin phosphodiesterase activity" IPR017064; IPR004843; Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-) Smpdl3b Asml3b Mus musculus (Mouse) TR26895_c2_g2_i2 Q92485 ASM3B_HUMAN 4.00E-30 GO:0005615; GO:0016798; GO:0006685; GO:0004767 "extracellular space; hydrolase activity, acting on glycosyl bonds; sphingomyelin catabolic process; sphingomyelin phosphodiesterase activity" IPR017064; IPR004843; Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-) SMPDL3B ASML3B Homo sapiens (Human) TR26895_c3_g1_i1 Q10916 ASM1_CAEEL 9.00E-09 GO:0046513; GO:0005576; GO:0016798; GO:0005764; GO:0006685; GO:0004767 "ceramide biosynthetic process; extracellular region; hydrolase activity, acting on glycosyl bonds; lysosome; sphingomyelin catabolic process; sphingomyelin phosphodiesterase activity" IPR004843; IPR011001; IPR008139; IPR011160; Lipid metabolism; sphingolipid metabolism. Sphingomyelin phosphodiesterase 1 (EC 3.1.4.12) (Acid sphingomyelinase 1) asm-1 B0252.2 Caenorhabditis elegans TR26899_c1_g1_i1 Q6ZSM3 MOT12_HUMAN 6.00E-25 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) SLC16A12 MCT12 Homo sapiens (Human) TR269_c0_g1_i1 Q9WUB9 MARCO_MESAU 1.00E-06 GO:0005581; GO:0045087; GO:0016021; GO:0005044 collagen; innate immune response; integral to membrane; scavenger receptor activity IPR008160; IPR001190; IPR017448; Macrophage receptor MARCO (Macrophage receptor with collagenous structure) MARCO Mesocricetus auratus (Golden hamster) TR26902_c2_g1_i1 Q801S4 K0930_XENLA 2.00E-78 IPR019141; Uncharacterized protein KIAA0930 homolog Xenopus laevis (African clawed frog) TR26905_c0_g1_i2 P10792 SODCP_PETHY 2.00E-31 GO:0009507; GO:0046872; GO:0004784; GO:0006801 chloroplast; metal ion binding; superoxide dismutase activity; superoxide metabolic process IPR024134; IPR018152; IPR001424; "Superoxide dismutase [Cu-Zn], chloroplastic (EC 1.15.1.1)" SODCP Petunia hybrida (Petunia) TR26906_c0_g1_i2 Q9I928 FUCL4_ANGJA 3.00E-09 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-4 Anguilla japonica (Japanese eel) TR2691_c0_g1_i1 H2A0M3 AMO_PINMG 4.00E-16 GO:0009308; GO:0005507; GO:0005576; GO:0008131; GO:0048038 amine metabolic process; copper ion binding; extracellular region; primary amine oxidase activity; quinone binding IPR000269; IPR015798; IPR016182; IPR015801; Putative amine oxidase [copper-containing] (EC 1.4.3.-) Pinctada margaritifera (Black-lipped pearl oyster) TR26914_c1_g1_i1 Q9Y5X5 NPFF2_HUMAN 6.00E-12 GO:0004930; GO:0015629; GO:0009582; GO:0005887; GO:0008188; GO:0007218; GO:0043408; GO:0045761; GO:2000479 G-protein coupled receptor activity; actin cytoskeleton; detection of abiotic stimulus; integral to plasma membrane; neuropeptide receptor activity; neuropeptide signaling pathway; regulation of MAPK cascade; regulation of adenylate cyclase activity; regulation of cAMP-dependent protein kinase activity IPR000276; IPR017452; IPR005395; IPR005397; Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) NPFFR2 GPR74 NPFF2 NPGPR Homo sapiens (Human) TR26914_c1_g1_i2 P97639 MCHR1_RAT 4.00E-12 GO:0007204; GO:0042562; GO:0016021; GO:0030273; GO:0007218; GO:0005886; GO:0051928; GO:0008022 elevation of cytosolic calcium ion concentration; hormone binding; integral to membrane; melanin-concentrating hormone receptor activity; neuropeptide signaling pathway; plasma membrane; positive regulation of calcium ion transport; protein C-terminus binding IPR000276; IPR017452; IPR004047; IPR008361; Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCH-R1) (MCHR-1) (G-protein coupled receptor 24) (MCH-1R) (MCH1R) (MCHR) (SLC-1) (Somatostatin receptor-like protein) (Fragment) Mchr1 Gpr24 Slc1 Rattus norvegicus (Rat) TR26914_c1_g1_i4 Q9Y5X5 NPFF2_HUMAN 1.00E-07 GO:0004930; GO:0015629; GO:0009582; GO:0005887; GO:0008188; GO:0007218; GO:0043408; GO:0045761; GO:2000479 G-protein coupled receptor activity; actin cytoskeleton; detection of abiotic stimulus; integral to plasma membrane; neuropeptide receptor activity; neuropeptide signaling pathway; regulation of MAPK cascade; regulation of adenylate cyclase activity; regulation of cAMP-dependent protein kinase activity IPR000276; IPR017452; IPR005395; IPR005397; Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) NPFFR2 GPR74 NPFF2 NPGPR Homo sapiens (Human) TR26915_c2_g1_i1 P30046 DOPD_HUMAN 8.00E-07 GO:0033981; GO:0005737; GO:0004167; GO:0042438 D-dopachrome decarboxylase activity; cytoplasm; dopachrome isomerase activity; melanin biosynthetic process IPR001398; IPR019829; IPR014347; D-dopachrome decarboxylase (EC 4.1.1.84) (D-dopachrome tautomerase) (Phenylpyruvate tautomerase II) DDT Homo sapiens (Human) TR26916_c0_g1_i1 P38892 CRG1_YEAST 4.00E-10 GO:0008757; GO:0005737; GO:0055088; GO:0003729 S-adenosylmethionine-dependent methyltransferase activity; cytoplasm; lipid homeostasis; mRNA binding IPR013216; Probable S-adenosylmethionine-dependent methyltransferase CRG1 (EC 2.1.1.-) (Cantharidin resistance protein 1) CRG1 YHR209W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR26916_c2_g1_i1 Q55EX9 Y8948_DICDI 4.00E-23 GO:0008168; GO:0045335 methyltransferase activity; phagocytic vesicle IPR013216; Putative methyltransferase DDB_G0268948 (EC 2.1.1.-) DDB_G0268948 Dictyostelium discoideum (Slime mold) TR26917_c1_g1_i1 Q02357 ANK1_MOUSE 3.00E-18 GO:0030863; GO:0048821; GO:0016020; GO:0015672; GO:0006779; GO:0016529; GO:0007165; GO:0014731 cortical cytoskeleton; erythrocyte development; membrane; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; sarcoplasmic reticulum; signal transduction; spectrin-associated cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) TR26917_c1_g2_i1 Q8NFD2 ANKK1_HUMAN 4.00E-16 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR001245; IPR008271; Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) TR2692_c0_g1_i1 Q02543 RL18A_HUMAN 2.00E-80 GO:0003723; GO:0006614; GO:0022625; GO:0000184; GO:0003735; GO:0006414; GO:0006413; GO:0006415; GO:0019083 "RNA binding; SRP-dependent cotranslational protein targeting to membrane; cytosolic large ribosomal subunit; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; translational elongation; translational initiation; translational termination; viral transcription" IPR021138; IPR023573; 60S ribosomal protein L18a RPL18A Homo sapiens (Human) TR26923_c1_g1_i1 A2BGA0 RFX4_DANRE 1.00E-22 GO:0003677; GO:0005634; GO:0006355; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003150; IPR011991; Transcription factor RFX4 (Regulatory factor X 4) rfx4 si:dkey-103i16.7 Danio rerio (Zebrafish) (Brachydanio rerio) TR26935_c1_g1_i1 Q8BQN6 OZF_MOUSE 2.00E-16 GO:0003677; GO:0005737; GO:0046872; GO:0005730 DNA binding; cytoplasm; metal ion binding; nucleolus IPR007087; IPR015880; IPR013087; Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146) Znf146 Ozf Zfp146 Mus musculus (Mouse) TR26937_c0_g1_i1 P07768 SUIS_RABIT 2.00E-08 GO:0016324; GO:0030246; GO:0005975; GO:0016021; GO:0004574; GO:0004575 "apical plasma membrane; carbohydrate binding; carbohydrate metabolic process; integral to membrane; oligo-1,6-glucosidase activity; sucrose alpha-glucosidase activity" IPR011013; IPR000322; IPR017853; IPR000519; IPR017957; "Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]" SI Oryctolagus cuniculus (Rabbit) TR26937_c1_g1_i1 Q2M2H8 MGAL2_HUMAN 2.00E-41 GO:0030246; GO:0005975; GO:0004553; GO:0016021 "carbohydrate binding; carbohydrate metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; integral to membrane" IPR011013; IPR000322; IPR017853; IPR000519; Putative inactive maltase-glucoamylase-like protein LOC93432 Homo sapiens (Human) TR26937_c1_g2_i1 Q6P7A9 LYAG_RAT 2.00E-53 GO:0004558; GO:0030246; GO:0005980; GO:0005765; GO:0005764; GO:0032450 alpha-glucosidase activity; carbohydrate binding; glycogen catabolic process; lysosomal membrane; lysosome; maltose alpha-glucosidase activity IPR011013; IPR000322; IPR025887; IPR017853; IPR000519; IPR017957; Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) Gaa Rattus norvegicus (Rat) TR26937_c2_g1_i1 O43451 MGA_HUMAN 5.00E-79 GO:0004558; GO:0016160; GO:0016324; GO:0030246; GO:0004339; GO:0016021; GO:0032450; GO:0005886; GO:0044245; GO:0044281; GO:0005983 "alpha-glucosidase activity; amylase activity; apical plasma membrane; carbohydrate binding; glucan 1,4-alpha-glucosidase activity; integral to membrane; maltose alpha-glucosidase activity; plasma membrane; polysaccharide digestion; small molecule metabolic process; starch catabolic process" IPR011013; IPR000322; IPR017853; IPR000519; IPR017957; "Maltase-glucoamylase, intestinal [Includes: Maltase (EC 3.2.1.20) (Alpha-glucosidase); Glucoamylase (EC 3.2.1.3) (Glucan 1,4-alpha-glucosidase)]" MGAM MGA MGAML Homo sapiens (Human) TR26938_c5_g1_i1 Q08DV6 ASB3_BOVIN 1.00E-09 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 3 (ASB-3) ASB3 Bos taurus (Bovine) TR26938_c6_g1_i1 Q812A3 ANR23_MOUSE 1.00E-10 GO:0031674; GO:0015629; GO:0006631; GO:0005634 I band; actin cytoskeleton; fatty acid metabolic process; nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) Ankrd23 Darp Mus musculus (Mouse) TR26943_c0_g1_i1 Q16829 DUS7_HUMAN 5.00E-16 GO:0017017; GO:0002755; GO:0035666; GO:0005829; GO:0045087; GO:0048011; GO:0005654; GO:0035335; GO:0004725; GO:0051403; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124 P10912 MAP kinase tyrosine/serine/threonine phosphatase activity; MyD88-dependent toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; cytosol; innate immune response; neurotrophin TRK receptor signaling pathway; nucleoplasm; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor TLR1:TLR2 signaling pathway; toll-like receptor TLR6:TLR2 signaling pathway IPR000340; IPR020422; IPR024950; IPR008343; IPR001763; IPR000387; Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST2) DUSP7 PYST2 Homo sapiens (Human) TR26943_c0_g1_i2 Q9JLY7 DUS14_MOUSE 3.00E-39 GO:0017017; GO:0005737; GO:0005634; GO:0035335; GO:0004725; GO:0008138 MAP kinase tyrosine/serine/threonine phosphatase activity; cytoplasm; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR020417; IPR020420; IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Dual specificity protein phosphatase 14 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6) Dusp14 Mkp6 Mus musculus (Mouse) TR26944_c1_g1_i1 P87033 GPA2_USTMA 5.00E-41 GO:0005525; GO:0003924; GO:0007189; GO:0046872; GO:0004871 GTP binding; GTPase activity; adenylate cyclase-activating G-protein coupled receptor signaling pathway; metal ion binding; signal transducer activity IPR002975; IPR001019; IPR011025; IPR027417; Guanine nucleotide-binding protein alpha-2 subunit GPA2 UM02517 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR26944_c1_g2_i1 Q9XZV3 GNAO_GEOCY 4.00E-56 GO:0007186; GO:0005525; GO:0006184; GO:0003924; GO:0046872; GO:0004871 G-protein coupled receptor signaling pathway; GTP binding; GTP catabolic process; GTPase activity; metal ion binding; signal transducer activity IPR001019; IPR011025; IPR027417; Guanine nucleotide-binding protein G(o) subunit alpha Geodia cydonium (Sponge) TR26946_c0_g1_i1 P25789 PSA4_HUMAN 1.00E-150 GO:0006977; GO:0000082; GO:0031145; GO:0002479; GO:0006915; GO:0000932; GO:0005829; GO:0010467; GO:0016071; GO:0019048; GO:0043066; GO:0051436; GO:0005654; GO:0051437; GO:0005839; GO:0019773; GO:0000209; GO:0006521; GO:0044281; GO:0004298; GO:0016032 P25786; P25787; P25788; P60900; O14818 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G1/S transition of mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic process; cytoplasmic mRNA processing body; cytosol; gene expression; mRNA metabolic process; modulation by virus of host morphology or physiology; negative regulation of apoptotic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; proteasome core complex; proteasome core complex, alpha-subunit complex; protein polyubiquitination; regulation of cellular amino acid metabolic process; small molecule metabolic process; threonine-type endopeptidase activity; viral process" IPR000426; IPR016050; IPR023332; IPR001353; Proteasome subunit alpha type-4 (EC 3.4.25.1) (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L) PSMA4 HC9 PSC9 Homo sapiens (Human) TR26947_c0_g1_i5 P37119 C71A3_SOLME 3.00E-06 GO:0020037; GO:0005506; GO:0004497; GO:0016705 "heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR002401; Cytochrome P450 71A3 (EC 1.14.-.-) (CYPLXXIA3) (Cytochrome P-450EG3) (Fragment) CYP71A3 CYPEG3 Solanum melongena (Eggplant) (Aubergine) TR26947_c0_g2_i1 Q92113 CP17A_SQUAC 5.00E-54 GO:0047442; GO:0020037; GO:0005506; GO:0016020; GO:0004508; GO:0006694 17-alpha-hydroxyprogesterone aldolase activity; heme binding; iron ion binding; membrane; steroid 17-alpha-monooxygenase activity; steroid biosynthetic process IPR001128; IPR017972; IPR002401; Lipid metabolism; steroid biosynthesis. "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.99.9) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Squalus acanthias (Spiny dogfish) TR26950_c0_g1_i1 O04226 P5CS_ORYSJ 2.00E-26 GO:0005524; GO:0055129; GO:0005737; GO:0004349; GO:0004350 ATP binding; L-proline biosynthetic process; cytoplasm; glutamate 5-kinase activity; glutamate-5-semialdehyde dehydrogenase activity IPR016161; IPR016163; IPR016162; IPR015590; IPR001048; IPR000965; IPR020593; IPR001057; IPR005715; IPR019797; IPR005766; Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. Delta-1-pyrroline-5-carboxylate synthase (P5CS) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] P5CS Os05g0455500 LOC_Os05g38150 OJ1651_D06.9 Oryza sativa subsp. japonica (Rice) TR26950_c2_g1_i2 Q5SH03 PROB_THET8 4.00E-08 GO:0005524; GO:0055129; GO:0003723; GO:0005737; GO:0004349 ATP binding; L-proline biosynthetic process; RNA binding; cytoplasm; glutamate 5-kinase activity IPR001048; IPR001057; IPR011529; IPR005715; IPR019797; IPR002478; IPR015947; Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. Glutamate 5-kinase (EC 2.7.2.11) (Gamma-glutamyl kinase) (GK) proB TTHA1927 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) TR26950_c2_g1_i3 P54889 ALH13_CAEEL 1.00E-39 GO:0005524; GO:0055129; GO:0004349; GO:0004350; GO:0005739 ATP binding; L-proline biosynthetic process; glutamate 5-kinase activity; glutamate-5-semialdehyde dehydrogenase activity; mitochondrion IPR016161; IPR016163; IPR016162; IPR015590; IPR001048; IPR000965; IPR020593; IPR001057; IPR005715; IPR019797; IPR005766; Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. Probable delta-1-pyrroline-5-carboxylate synthase (P5CS) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Aldehyde dehydrogenase family 13) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] alh-13 T22H6.2 Caenorhabditis elegans TR26953_c0_g1_i1 Q567G2 WDR73_DANRE 1.00E-47 IPR015943; IPR001680; IPR017986; WD repeat-containing protein 73 wdr73 zgc:112071 Danio rerio (Zebrafish) (Brachydanio rerio) TR26956_c1_g4_i2 Q9LPV5 NRT25_ARATH 1.00E-66 GO:0016021; GO:0042128; GO:0005886; GO:0055085 integral to membrane; nitrate assimilation; plasma membrane; transmembrane transport IPR011701; IPR016196; High affinity nitrate transporter 2.5 (AtNRT2:5) NRT2.5 At1g12940 F13K23.20 Arabidopsis thaliana (Mouse-ear cress) TR26958_c0_g2_i1 P29030 CHIT_BRUMA 8.00E-07 GO:0008061; GO:0006032; GO:0004568; GO:0005576; GO:0000272 chitin binding; chitin catabolic process; chitinase activity; extracellular region; polysaccharide catabolic process IPR002557; IPR011583; IPR001223; IPR001579; IPR013781; IPR017853; Endochitinase (EC 3.2.1.14) (MF1 antigen) Brugia malayi (Filarial nematode worm) TR26958_c0_g2_i3 P29030 CHIT_BRUMA 1.00E-06 GO:0008061; GO:0006032; GO:0004568; GO:0005576; GO:0000272 chitin binding; chitin catabolic process; chitinase activity; extracellular region; polysaccharide catabolic process IPR002557; IPR011583; IPR001223; IPR001579; IPR013781; IPR017853; Endochitinase (EC 3.2.1.14) (MF1 antigen) Brugia malayi (Filarial nematode worm) TR26959_c0_g1_i1 Q6TDU1 MGMT_CANFA 9.00E-36 GO:0003677; GO:0006281; GO:0046872; GO:0003908; GO:0005634 DNA binding; DNA repair; metal ion binding; methylated-DNA-[protein]-cysteine S-methyltransferase activity; nucleus IPR001497; IPR014048; IPR008332; IPR011991; Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase) MGMT Canis familiaris (Dog) (Canis lupus familiaris) TR26960_c1_g1_i1 O88974 SETB1_MOUSE 9.00E-19 GO:0003677; GO:0060348; GO:0005694; GO:0018024; GO:0001833; GO:0005634; GO:0006355; GO:0006351; GO:0008270 P81270 "DNA binding; bone development; chromosome; histone-lysine N-methyltransferase activity; inner cell mass cell proliferation; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR016177; IPR025796; IPR001739; IPR003616; IPR007728; IPR003606; IPR001214; IPR002999; Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.43) (ERG-associated protein with SET domain) (ESET) (SET domain bifurcated 1) Setdb1 Eset Kiaa0067 Mus musculus (Mouse) TR26970_c3_g1_i2 Q5T197 DCST1_HUMAN 2.00E-14 GO:0016021; GO:0008270 integral to membrane; zinc ion binding IPR012858; IPR001841; DC-STAMP domain-containing protein 1 DCST1 Homo sapiens (Human) TR26971_c1_g1_i1 A4QP81 FRRS1_DANRE 6.00E-08 GO:0016021; GO:0016491 integral to membrane; oxidoreductase activity IPR006593; IPR005018; IPR002861; Putative ferric-chelate reductase 1 (EC 1.-.-.-) frrs1 zgc:163022 Danio rerio (Zebrafish) (Brachydanio rerio) TR26971_c1_g1_i2 Q0Q028 DFP3_ANTMY 1.00E-12 GO:0042742; GO:0042832; GO:0005576; GO:0045087 defense response to bacterium; defense response to protozoan; extracellular region; innate immune response IPR002861; Putative defense protein 3 (DFP-3) Antheraea mylitta (Tasar silkworm) TR26972_c0_g1_i1 Q502K3 ANR52_DANRE 2.00E-21 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) TR26974_c3_g1_i1 Q29RY7 FGL2_BOVIN 1.00E-29 GO:0009986; GO:0005576; GO:0016504 cell surface; extracellular region; peptidase activator activity IPR014716; IPR014715; IPR002181; IPR020837; Fibroleukin (Fibrinogen-like protein 2) FGL2 Bos taurus (Bovine) TR26980_c1_g1_i1 Q947C5 HBL1_GOSHI 8.00E-14 GO:0020037; GO:0005506; GO:0019825; GO:0015671 heme binding; iron ion binding; oxygen binding; oxygen transport IPR000971; IPR009050; IPR012292; IPR001032; Non-symbiotic hemoglobin 1 (GOShi GLB1) (Hb1) HB1 GLB1 Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) TR26980_c1_g1_i2 Q947C5 HBL1_GOSHI 3.00E-16 GO:0020037; GO:0005506; GO:0019825; GO:0015671 heme binding; iron ion binding; oxygen binding; oxygen transport IPR000971; IPR009050; IPR012292; IPR001032; Non-symbiotic hemoglobin 1 (GOShi GLB1) (Hb1) HB1 GLB1 Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) TR26980_c1_g1_i3 P86881 NGB_DISMA 2.00E-15 GO:0005737; GO:0020037; GO:0005506; GO:0019825; GO:0005344; GO:0043204 cytoplasm; heme binding; iron ion binding; oxygen binding; oxygen transporter activity; perikaryon IPR000971; IPR009050; IPR012292; IPR001032; Neuroglobin Dissostichus mawsoni (Antarctic cod) TR26981_c2_g1_i1 Q5QJ74 TBCEL_HUMAN 2.00E-67 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR027933; IPR000626; Tubulin-specific chaperone cofactor E-like protein (EL) (Leucine-rich repeat-containing protein 35) TBCEL LRRC35 Homo sapiens (Human) TR26981_c2_g1_i2 Q5PQJ7 TBCEL_RAT 2.00E-65 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR027933; IPR000626; Tubulin-specific chaperone cofactor E-like protein (Leucine-rich repeat-containing protein 35) Tbcel Lrrc35 Rattus norvegicus (Rat) TR26981_c3_g1_i5 Q5QJ74 TBCEL_HUMAN 4.00E-08 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR027933; IPR000626; Tubulin-specific chaperone cofactor E-like protein (EL) (Leucine-rich repeat-containing protein 35) TBCEL LRRC35 Homo sapiens (Human) TR26984_c0_g1_i1 Q5TYP8 CA095_DANRE 1.00E-15 GO:0016021 integral to membrane IPR026673; Uncharacterized transmembrane protein C1orf95 homolog si:dkeyp-59a8.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR26985_c0_g1_i2 P70684 PGDH_CAVPO 3.00E-59 GO:0016404; GO:0070403; GO:0005737; GO:0097070; GO:0007565; GO:0045786; GO:0030728; GO:0007567; GO:0004957; GO:0006693; GO:0070493; GO:0007179 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; NAD+ binding; cytoplasm; ductus arteriosus closure; female pregnancy; negative regulation of cell cycle; ovulation; parturition; prostaglandin E receptor activity; prostaglandin metabolic process; thrombin receptor signaling pathway; transforming growth factor beta receptor signaling pathway IPR002198; IPR002347; IPR016040; IPR020904; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) HPGD PGDH1 Cavia porcellus (Guinea pig) TR26987_c0_g1_i1 Q8NG31 CASC5_HUMAN 2.00E-07 GO:0034080; GO:0001669; GO:0001675; GO:0008608; GO:0051301; GO:0000777; GO:0005829; GO:0007067; GO:0000278; GO:0010923; GO:0005654; GO:0034501; GO:0071173 P62136 CENP-A containing nucleosome assembly at centromere; acrosomal vesicle; acrosome assembly; attachment of spindle microtubules to kinetochore; cell division; condensed chromosome kinetochore; cytosol; mitosis; mitotic cell cycle; negative regulation of phosphatase activity; nucleoplasm; protein localization to kinetochore; spindle assembly checkpoint Protein CASC5 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore-null protein 1) (Protein D40/AF15q14) CASC5 KIAA1570 KNL1 Homo sapiens (Human) TR26989_c0_g1_i1 P53369 8ODP_RAT 3.00E-38 GO:0035539; GO:0008413; GO:0006200; GO:0047693; GO:0042262; GO:0006281; GO:0006184; GO:0001669; GO:0006203; GO:0046872; GO:0005759; GO:0031965; GO:0005634; GO:0030515 "8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity; ATP catabolic process; ATP diphosphatase activity; DNA protection; DNA repair; GTP catabolic process; acrosomal vesicle; dGTP catabolic process; metal ion binding; mitochondrial matrix; nuclear membrane; nucleus; snoRNA binding" IPR020476; IPR020084; IPR000086; IPR015797; IPR003563; "7,8-dihydro-8-oxoguanine triphosphatase (EC 3.6.1.55) (2-hydroxy-dATP diphosphatase) (EC 3.6.1.56) (8-oxo-dGTPase) (Nucleoside diphosphate-linked moiety X motif 1) (Nudix motif 1)" Nudt1 Mth1 Rattus norvegicus (Rat) TR26989_c0_g2_i1 P36639 8ODP_HUMAN 3.00E-39 GO:0035539; GO:0008413; GO:0006200; GO:0047693; GO:0042262; GO:0006281; GO:0003924; GO:0005829; GO:0006203; GO:0046872; GO:0005759; GO:0034656; GO:0005634; GO:0006979; GO:0030515 "8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity; ATP catabolic process; ATP diphosphatase activity; DNA protection; DNA repair; GTPase activity; cytosol; dGTP catabolic process; metal ion binding; mitochondrial matrix; nucleobase-containing small molecule catabolic process; nucleus; response to oxidative stress; snoRNA binding" IPR020476; IPR020084; IPR000086; IPR015797; IPR003563; "7,8-dihydro-8-oxoguanine triphosphatase (EC 3.6.1.55) (2-hydroxy-dATP diphosphatase) (EC 3.6.1.56) (8-oxo-dGTPase) (Nucleoside diphosphate-linked moiety X motif 1) (Nudix motif 1)" NUDT1 MTH1 Homo sapiens (Human) TR26990_c0_g1_i1 Q5D1E7 ZC12A_MOUSE 1.00E-61 GO:0001525; GO:0006915; GO:0030154; GO:0071222; GO:0005737; GO:0004519; GO:0046872; GO:0032088; GO:0010629; GO:0032715; GO:0045019; GO:0032720; GO:0090305; GO:0005634; GO:0005886; GO:0010508; GO:0045600; GO:0010628; GO:0010884; GO:2000379 O14920; P51617 angiogenesis; apoptotic process; cell differentiation; cellular response to lipopolysaccharide; cytoplasm; endonuclease activity; metal ion binding; negative regulation of NF-kappaB transcription factor activity; negative regulation of gene expression; negative regulation of interleukin-6 production; negative regulation of nitric oxide biosynthetic process; negative regulation of tumor necrosis factor production; nucleic acid phosphodiester bond hydrolysis; nucleus; plasma membrane; positive regulation of autophagy; positive regulation of fat cell differentiation; positive regulation of gene expression; positive regulation of lipid storage; positive regulation of reactive oxygen species metabolic process IPR021869; Ribonuclease ZC3H12A (EC 3.1.-.-) (MCP-induced protein 1) (Zinc finger CCCH domain-containing protein 12A) Zc3h12a Mcpip Mcpip1 Mus musculus (Mouse) TR26992_c0_g1_i1 O02811 PI4KA_BOVIN 2.00E-37 GO:0004430; GO:0005524; GO:0048015 1-phosphatidylinositol 4-kinase activity; ATP binding; phosphatidylinositol-mediated signaling IPR016024; IPR011009; IPR000403; IPR018936; IPR015433; IPR001263; Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) PI4KA PIK4CA Bos taurus (Bovine) TR26996_c0_g1_i1 G5EBU4 ZAG1_CAEEL 3.00E-06 GO:0007411; GO:0046872; GO:0000122; GO:0005634; GO:0045773; GO:0043565; GO:0003700; GO:0006351 "axon guidance; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of axon extension; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; IPR007087; IPR015880; IPR013087; Zinc finger E-box-binding homeobox protein zag-1 (Zinc finger involved in axon guidance 1) (ZAG-1) zag-1 F28F9.1 Caenorhabditis elegans TR26996_c0_g1_i2 A2T812 ZN287_PONPY 4.00E-18 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein 287 ZNF287 Pongo pygmaeus (Bornean orangutan) TR26998_c0_g1_i1 Q9P1V8 SAM15_HUMAN 1.00E-28 IPR001660; IPR013761; IPR011510; Sterile alpha motif domain-containing protein 15 (SAM domain-containing protein 15) SAMD15 C14orf174 FAM15A Homo sapiens (Human) TR2700_c0_g2_i1 Q08378 GOGA3_HUMAN 3.00E-06 GO:0032580; GO:0000139; GO:0017119; GO:0005793; GO:0006891; GO:0005634; GO:0005215 Golgi cisterna membrane; Golgi membrane; Golgi transport complex; endoplasmic reticulum-Golgi intermediate compartment; intra-Golgi vesicle-mediated transport; nucleus; transporter activity Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) GOLGA3 Homo sapiens (Human) TR27000_c0_g1_i1 Q6P3N6 CDK8_XENTR 0 GO:0005524; GO:0008353; GO:0004693; GO:0005634; GO:0006355; GO:0006351 "ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; cyclin-dependent protein serine/threonine kinase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit cdk8) (Mediator of RNA polymerase II transcription subunit cdk8) cdk8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR27002_c0_g1_i2 Q9VH78 ALG12_DROME 9.00E-134 GO:0000009; GO:0052917; GO:0006488; GO:0005783; GO:0005789; GO:0016021; GO:0006486 "alpha-1,6-mannosyltransferase activity; dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity; dolichol-linked oligosaccharide biosynthetic process; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; protein glycosylation" IPR005599; Protein modification; protein glycosylation. "Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (EC 2.4.1.260) (Asparagine-linked glycosylation protein 12 homolog) (Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase) (Mannosyltransferase ALG12 homolog)" CG8412 Drosophila melanogaster (Fruit fly) TR27002_c0_g1_i3 Q9VH78 ALG12_DROME 8.00E-135 GO:0000009; GO:0052917; GO:0006488; GO:0005783; GO:0005789; GO:0016021; GO:0006486 "alpha-1,6-mannosyltransferase activity; dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity; dolichol-linked oligosaccharide biosynthetic process; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; protein glycosylation" IPR005599; Protein modification; protein glycosylation. "Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (EC 2.4.1.260) (Asparagine-linked glycosylation protein 12 homolog) (Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase) (Mannosyltransferase ALG12 homolog)" CG8412 Drosophila melanogaster (Fruit fly) TR27005_c0_g1_i4 Q98TZ8 FLOT2_DANRE 2.00E-63 GO:0007155; GO:0030139; GO:0005768; GO:0016020 cell adhesion; endocytic vesicle; endosome; membrane IPR001107; IPR027705; Flotillin-2a (Reggie-1a) (REG-1) flot2a Danio rerio (Zebrafish) (Brachydanio rerio) TR27006_c1_g1_i1 Q7ZTZ2 RLP24_DANRE 5.00E-69 GO:0005730; GO:0042254 nucleolus; ribosome biogenesis IPR023442; IPR023441; IPR000988; IPR024546; IPR011017; Probable ribosome biogenesis protein RLP24 (Ribosomal L24 domain-containing protein 1) rsl24d1 zgc:56202 Danio rerio (Zebrafish) (Brachydanio rerio) TR27009_c0_g1_i2 Q95JD5 ST1B1_CANFA 3.00E-21 GO:0004062; GO:0005737; GO:0009812; GO:0008202; GO:0051923; GO:0042403; GO:0006805 aryl sulfotransferase activity; cytoplasm; flavonoid metabolic process; steroid metabolic process; sulfation; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (cSULT1B1) (EC 2.8.2.-) SULT1B1 ST1B2 Canis familiaris (Dog) (Canis lupus familiaris) TR27011_c0_g1_i2 A9UMU8 CG059_XENTR 2.00E-20 GO:0071986; GO:0071230; GO:0005764; GO:0032008; GO:0061462; GO:0008361 Ragulator complex; cellular response to amino acid stimulus; lysosome; positive regulation of TOR signaling cascade; protein localization to lysosome; regulation of cell size IPR004942; Ragulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4) lamtor4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR27011_c0_g1_i3 Q0P3X8 CG059_DANRE 4.00E-23 GO:0071986; GO:0071230; GO:0005764; GO:0032008; GO:0061462; GO:0008361 Ragulator complex; cellular response to amino acid stimulus; lysosome; positive regulation of TOR signaling cascade; protein localization to lysosome; regulation of cell size Ragulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4) lamtor4 si:dkey-159a18.7 Danio rerio (Zebrafish) (Brachydanio rerio) TR27011_c0_g1_i4 Q9VZL6 U539_DROME 5.00E-11 GO:0071986; GO:0071230; GO:0005764; GO:0032008; GO:0061462; GO:0008361 Q7K306 Ragulator complex; cellular response to amino acid stimulus; lysosome; positive regulation of TOR signaling cascade; protein localization to lysosome; regulation of cell size Ragulator complex protein LAMTOR4 homolog (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4) CG14977 Drosophila melanogaster (Fruit fly) TR27011_c0_g1_i5 Q54DY3 U539_DICDI 2.00E-06 GO:0071986; GO:0071230; GO:0005764; GO:0032008; GO:0061462; GO:0008361 Ragulator complex; cellular response to amino acid stimulus; lysosome; positive regulation of TOR signaling cascade; protein localization to lysosome; regulation of cell size Ragulator complex protein LAMTOR4 homolog (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4) DDB_G0291948 Dictyostelium discoideum (Slime mold) TR27012_c0_g1_i1 P62912 RL32_RAT 2.00E-76 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001515; IPR018263; 60S ribosomal protein L32 Rpl32 Rattus norvegicus (Rat) TR27014_c1_g2_i1 O89110 CASP8_MOUSE 4.00E-07 GO:0030690; GO:0006919; GO:0001525; GO:0071260; GO:0005813; GO:0097153; GO:0031264; GO:0008625; GO:0007507; GO:0097284; GO:0030225; GO:0005739; GO:0043124; GO:0060546; GO:0001841; GO:0043123; GO:2001238; GO:0045651; GO:0045862; GO:0051603; GO:0070243; GO:0034612 P10275; P19091; P25446; Q9D8Y7 Noc1p-Noc2p complex; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; death-inducing signaling complex; extrinsic apoptotic signaling pathway via death domain receptors; heart development; hepatocyte apoptotic process; macrophage differentiation; mitochondrion; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of necroptosis; neural tube formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of macrophage differentiation; positive regulation of proteolysis; proteolysis involved in cellular protein catabolic process; regulation of thymocyte apoptotic process; response to tumor necrosis factor IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] Casp8 Mus musculus (Mouse) TR27015_c1_g1_i2 Q9H147 TDIF1_HUMAN 5.00E-69 GO:0005634 nucleus IPR026064; Deoxynucleotidyltransferase terminal-interacting protein 1 (Terminal deoxynucleotidyltransferase-interacting factor 1) (TdIF1) (TdT-interacting factor 1) DNTTIP1 C20orf167 TDIF1 Homo sapiens (Human) TR27017_c3_g1_i1 B3NVC6 T23O_DROER 1.00E-136 GO:0020037; GO:0046872; GO:0006727; GO:0004833; GO:0019441 "heme binding; metal ion binding; ommochrome biosynthetic process; tryptophan 2,3-dioxygenase activity; tryptophan catabolic process to kynurenine" IPR004981; Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. Pigment biosynthesis; ommochrome biosynthesis. "Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Protein vermilion) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)" v GG18380 Drosophila erecta (Fruit fly) TR27020_c3_g1_i1 Q2YDP3 NC2A_BOVIN 3.00E-42 GO:0005634; GO:0006355; GO:0043565; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription, DNA-dependent" IPR003958; IPR009072; Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha) DRAP1 Bos taurus (Bovine) TR27021_c1_g1_i2 Q04833 LRP_CAEEL 5.00E-14 GO:0016324; GO:0005509; GO:0005905; GO:0042395; GO:0030139; GO:0006897; GO:0016021; GO:0002119; GO:0040017; GO:0040018; GO:0030334; GO:0015248 "apical plasma membrane; calcium ion binding; coated pit; ecdysis, collagen and cuticulin-based cuticle; endocytic vesicle; endocytosis; integral to membrane; nematode larval development; positive regulation of locomotion; positive regulation of multicellular organism growth; regulation of cell migration; sterol transporter activity" IPR011042; IPR000742; IPR001881; IPR013032; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein (LRP) lrp-1 F29D11.1 Caenorhabditis elegans TR27022_c0_g1_i2 Q9H6D7 HAUS4_HUMAN 8.00E-23 GO:0070652; GO:0051301; GO:0005813; GO:0051297; GO:0005737; GO:0005874; GO:0007067; GO:0005819; GO:0051225 HAUS complex; cell division; centrosome; centrosome organization; cytoplasm; microtubule; mitosis; spindle; spindle assembly IPR026214; HAUS augmin-like complex subunit 4 HAUS4 C14orf94 Homo sapiens (Human) TR27022_c0_g2_i1 Q8BFT2 HAUS4_MOUSE 3.00E-22 GO:0070652; GO:0051301; GO:0051297; GO:0005737; GO:0005874; GO:0005815; GO:0007067; GO:0005819; GO:0051225 HAUS complex; cell division; centrosome organization; cytoplasm; microtubule; microtubule organizing center; mitosis; spindle; spindle assembly IPR026214; HAUS augmin-like complex subunit 4 Haus4 D14Ertd500e Mus musculus (Mouse) TR27028_c0_g3_i1 Q7SXR3 MAEA_DANRE 4.00E-11 GO:0007049; GO:0051301; GO:0005737; GO:0005856; GO:0043249; GO:0016363; GO:0005886 cell cycle; cell division; cytoplasm; cytoskeleton; erythrocyte maturation; nuclear matrix; plasma membrane IPR013144; IPR024964; IPR006595; IPR006594; Macrophage erythroblast attacher maea zgc:63708 Danio rerio (Zebrafish) (Brachydanio rerio) TR27028_c0_g3_i2 Q640V2 RMD5A_XENTR 1.00E-152 IPR013144; IPR024964; IPR006595; IPR006594; IPR027370; IPR013083; Protein RMD5 homolog A rmnd5a TGas140j12.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR27031_c1_g1_i1 Q9DB20 ATPO_MOUSE 9.00E-57 GO:0015986; GO:0005753; GO:0000276; GO:0046933; GO:0005496 "ATP synthesis coupled proton transport; mitochondrial proton-transporting ATP synthase complex; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); proton-transporting ATP synthase activity, rotational mechanism; steroid binding" IPR000711; IPR020781; IPR026015; "ATP synthase subunit O, mitochondrial (Oligomycin sensitivity conferral protein) (OSCP)" Atp5o D12Wsu28e Mus musculus (Mouse) TR27034_c0_g1_i1 Q8C8H8 KY_MOUSE 3.00E-14 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) TR27035_c1_g1_i1 P30874 SSR2_HUMAN 8.00E-25 GO:0007187; GO:0007193; GO:0071392; GO:0071385; GO:0021549; GO:0005737; GO:0007586; GO:0030900; GO:0005887; GO:0008285; GO:0030432; GO:0006937; GO:0007584; GO:0042594; GO:0004994; GO:0007283 P27986; P32745 "G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; cellular response to estradiol stimulus; cellular response to glucocorticoid stimulus; cerebellum development; cytoplasm; digestion; forebrain development; integral to plasma membrane; negative regulation of cell proliferation; peristalsis; regulation of muscle contraction; response to nutrient; response to starvation; somatostatin receptor activity; spermatogenesis" IPR000276; IPR017452; IPR000586; IPR002074; Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SRIF-1) SSTR2 Homo sapiens (Human) TR27038_c0_g1_i1 Q9D5I4 TC1D1_MOUSE 8.00E-21 IPR005334; Tctex1 domain-containing protein 1 Tctex1d1 Mus musculus (Mouse) TR27042_c0_g2_i1 Q86H36 RPA1_DICDI 4.00E-31 GO:0003677; GO:0005736; GO:0003899; GO:0006360; GO:0008270 DNA binding; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase activity; transcription from RNA polymerase I promoter; zinc ion binding IPR015699; IPR000722; IPR006592; IPR007080; IPR007066; IPR007083; IPR007081; DNA-directed RNA polymerase I subunit rpa1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) polr1a rpa1 DDB_G0275759 Dictyostelium discoideum (Slime mold) TR27042_c0_g2_i2 Q196X0 RPB1_IIV3 3.00E-08 GO:0003677; GO:0003899; GO:0046872; GO:0006351 "DNA binding; DNA-directed RNA polymerase activity; metal ion binding; transcription, DNA-dependent" IPR000722; IPR006592; IPR007080; IPR007066; IPR007083; IPR007081; Probable DNA-directed RNA polymerase II subunit RPB1 homolog (EC 2.7.7.6) IIV3-090L Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus) TR27042_c0_g2_i3 P15398 RPA1_SCHPO 6.00E-30 GO:0003677; GO:0005736; GO:0003899; GO:0005829; GO:0006406; GO:0007000; GO:0034503; GO:0006360; GO:0008270 DNA binding; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase activity; cytosol; mRNA export from nucleus; nucleolus organization; protein localization to nucleolar rDNA repeats; transcription from RNA polymerase I promoter; zinc ion binding IPR015699; IPR000722; IPR006592; IPR007080; IPR007066; IPR007083; IPR007081; DNA-directed RNA polymerase I subunit rpa1 (EC 2.7.7.6) (DNA-directed RNA polymerase I 190 kDa polypeptide) (DNA-directed RNA polymerase I largest subunit) rpa1 nuc1 SPBC4C3.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR27043_c0_g1_i1 Q29RH4 THOC3_BOVIN 1.00E-163 GO:0003723; GO:0008380; GO:0006397; GO:0051028; GO:0005634 RNA binding; RNA splicing; mRNA processing; mRNA transport; nucleus IPR020472; IPR011659; IPR015943; IPR001680; IPR017986; THO complex subunit 3 (Tho3) THOC3 Bos taurus (Bovine) TR27043_c0_g2_i1 O00628 PEX7_HUMAN 8.00E-08 GO:0005829; GO:0001958; GO:0008611; GO:0006635; GO:0001764; GO:0005782; GO:0005053; GO:0042803; GO:0016558 cytosol; endochondral ossification; ether lipid biosynthetic process; fatty acid beta-oxidation; neuron migration; peroxisomal matrix; peroxisome matrix targeting signal-2 binding; protein homodimerization activity; protein import into peroxisome matrix IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7) PEX7 PTS2R Homo sapiens (Human) TR27045_c0_g1_i1 Q3ZBX1 PIGC_BOVIN 1.00E-88 GO:0006506; GO:0005789; GO:0016021; GO:0017176 GPI anchor biosynthetic process; endoplasmic reticulum membrane; integral to membrane; phosphatidylinositol N-acetylglucosaminyltransferase activity IPR009450; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class C protein) (PIG-C) PIGC Bos taurus (Bovine) TR27046_c6_g1_i1 Q80VI1 TRI56_MOUSE 1.00E-06 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) TR27048_c2_g3_i1 Q9UPW0 FOXJ3_HUMAN 7.00E-69 GO:0008301; GO:0009790; GO:0005634; GO:0007389; GO:0045893; GO:0043565; GO:0003700; GO:0009888; GO:0006351 "DNA binding, bending; embryo development; nucleus; pattern specification process; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; tissue development; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; Forkhead box protein J3 FOXJ3 KIAA1041 Homo sapiens (Human) TR27049_c0_g1_i1 Q8HXX6 SAP3_MACFA 9.00E-13 GO:0016787; GO:0005764; GO:0006665 hydrolase activity; lysosome; sphingolipid metabolic process IPR003172; Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) GM2A QccE-17591 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR27050_c0_g1_i2 Q8NBN7 RDH13_HUMAN 2.00E-78 GO:0005739; GO:0016491 mitochondrion; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Retinol dehydrogenase 13 (EC 1.1.1.-) RDH13 PSEC0082 UNQ736/PRO1430 Homo sapiens (Human) TR27050_c0_g1_i3 Q8NBN7 RDH13_HUMAN 9.00E-79 GO:0005739; GO:0016491 mitochondrion; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Retinol dehydrogenase 13 (EC 1.1.1.-) RDH13 PSEC0082 UNQ736/PRO1430 Homo sapiens (Human) TR27051_c0_g1_i1 P12107 COBA1_HUMAN 3.00E-54 GO:0001502; GO:0002063; GO:0030574; GO:0030199; GO:0005592; GO:0050910; GO:0048704; GO:0005788; GO:0050840; GO:0022617; GO:0005201; GO:0042472; GO:0046872; GO:0030674; GO:0006029; GO:0035989; GO:0055010; GO:0007601 "cartilage condensation; chondrocyte development; collagen catabolic process; collagen fibril organization; collagen type XI; detection of mechanical stimulus involved in sensory perception of sound; embryonic skeletal system morphogenesis; endoplasmic reticulum lumen; extracellular matrix binding; extracellular matrix disassembly; extracellular matrix structural constituent; inner ear morphogenesis; metal ion binding; protein binding, bridging; proteoglycan metabolic process; tendon development; ventricular cardiac muscle tissue morphogenesis; visual perception" IPR008160; IPR008985; IPR013320; IPR000885; IPR001791; Collagen alpha-1(XI) chain COL11A1 COLL6 Homo sapiens (Human) TR27052_c0_g1_i1 Q5VYJ5 CJ112_HUMAN 1.00E-23 GO:0016021 integral to membrane IPR008985; IPR023415; IPR002172; IPR000998; MAM and LDL-receptor class A domain-containing protein C10orf112 C10orf112 Homo sapiens (Human) TR27055_c0_g1_i1 Q1NZ26 YSMU_CAEEL 6.00E-83 GO:0003824; GO:0005739 catalytic activity; mitochondrion IPR013785; IPR005137; IPR011060; "Uncharacterized protein F13E9.13, mitochondrial" F13E9.13 Caenorhabditis elegans TR27056_c1_g2_i1 Q13797 ITA9_HUMAN 8.00E-07 GO:0007411; GO:0009925; GO:0007155; GO:0030198; GO:0008305; GO:0007229; GO:0046872; GO:0030593 axon guidance; basal plasma membrane; cell adhesion; extracellular matrix organization; integrin complex; integrin-mediated signaling pathway; metal ion binding; neutrophil chemotaxis IPR013517; IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha-9 (Integrin alpha-RLC) ITGA9 Homo sapiens (Human) TR27059_c6_g1_i1 A6H8Y1 BDP1_HUMAN 6.00E-06 GO:0003677; GO:0003682; GO:0005654; GO:0006355; GO:0006383 "DNA binding; chromatin binding; nucleoplasm; regulation of transcription, DNA-dependent; transcription from RNA polymerase III promoter" IPR009057; IPR001005; Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) BDP1 KIAA1241 KIAA1689 TFNR Homo sapiens (Human) TR27061_c0_g1_i2 Q6P6M7 SPCS_MOUSE 0 GO:0005737; GO:0005634; GO:0030170; GO:0001514; GO:0097056; GO:0000049; GO:0016785 "cytoplasm; nucleus; pyridoxal phosphate binding; selenocysteine incorporation; selenocysteinyl-tRNA(Sec) biosynthetic process; tRNA binding; transferase activity, transferring selenium-containing groups" IPR015424; IPR015421; IPR019872; IPR008829; Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2. O-phosphoseryl-tRNA(Sec) selenium transferase (EC 2.9.1.2) (Selenocysteine synthase) (Sec synthase) (Selenocysteinyl-tRNA(Sec) synthase) (Sep-tRNA:Sec-tRNA synthase) (SepSecS) (UGA suppressor tRNA-associated protein) Sepsecs D5Ertd135e Mus musculus (Mouse) TR27068_c1_g1_i1 D3ZR35 CF228_RAT 2.00E-09 GO:0016021 integral to membrane Small integral membrane protein 13 Smim13 Rattus norvegicus (Rat) TR27071_c0_g1_i1 P19761 TFPI1_RABIT 1.00E-22 GO:0007596; GO:0005576; GO:0004867 blood coagulation; extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR008296; IPR020901; Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI) TFPI Oryctolagus cuniculus (Rabbit) TR27071_c0_g1_i2 P84875 PCPI_SABMA 2.00E-27 GO:0008191; GO:0004867 metalloendopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Carboxypeptidase inhibitor SmCI Sabellastarte magnifica (Feather duster) TR27074_c0_g1_i2 O94817 ATG12_HUMAN 8.00E-41 GO:0000045; GO:0045087; GO:0032480; GO:0034045; GO:0043234 autophagic vacuole assembly; innate immune response; negative regulation of type I interferon production; pre-autophagosomal structure membrane; protein complex IPR007242; Ubiquitin-like protein ATG12 (Autophagy-related protein 12) (APG12-like) ATG12 APG12 APG12L Homo sapiens (Human) TR27076_c2_g1_i1 P15535 B4GT1_MOUSE 3.00E-67 GO:0005794; GO:0032580; GO:0000138; GO:0003945; GO:0002526; GO:0060055; GO:0016323; GO:0003831; GO:0007339; GO:0048754; GO:0031526; GO:0007155; GO:0009986; GO:0008092; GO:0030057; GO:0045136; GO:0002064; GO:0009897; GO:0030198; GO:0005576; GO:0006012; GO:0030112; GO:0016021; GO:0005989; GO:0004461; GO:0050900; GO:0030879; GO:0046872; GO:0008285; GO:0009312; GO:0007341; GO:0005886; GO:0060058; GO:0060054; GO:0006486; GO:0060046; GO:0051270 "Golgi apparatus; Golgi cisterna membrane; Golgi trans cisterna; N-acetyllactosamine synthase activity; acute inflammatory response; angiogenesis involved in wound healing; basolateral plasma membrane; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; binding of sperm to zona pellucida; branching morphogenesis of an epithelial tube; brush border membrane; cell adhesion; cell surface; cytoskeletal protein binding; desmosome; development of secondary sexual characteristics; epithelial cell development; external side of plasma membrane; extracellular matrix organization; extracellular region; galactose metabolic process; glycocalyx; integral to membrane; lactose biosynthetic process; lactose synthase activity; leukocyte migration; mammary gland development; metal ion binding; negative regulation of cell proliferation; oligosaccharide biosynthetic process; penetration of zona pellucida; plasma membrane; positive regulation of apoptotic process involved in mammary gland involution; positive regulation of epithelial cell proliferation involved in wound healing; protein glycosylation; regulation of acrosome reaction; regulation of cellular component movement" IPR003859; IPR027791; IPR027995; Protein modification; protein glycosylation. "Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1] [Includes: Lactose synthase A protein (EC 2.4.1.22); N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthase); Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)]" B4galt1 Ggtb Ggtb2 Mus musculus (Mouse) TR27077_c0_g1_i1 Q0V9D9 SELR1_XENTR 3.00E-30 IPR006597; IPR011990; Sel1 repeat-containing protein 1 (Beta-lactamase hcp-like protein SELRC1) selrc1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR27079_c1_g1_i1 Q7Z4K8 TRI46_HUMAN 2.00E-06 GO:0005622; GO:0008270 intracellular; zinc ion binding IPR001870; IPR008985; IPR017903; IPR003961; IPR013783; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; "Tripartite motif-containing protein 46 (Gene Y protein) (GeneY) (Tripartite, fibronectin type-III and C-terminal SPRY motif protein)" TRIM46 TRIFIC Homo sapiens (Human) TR27083_c0_g1_i1 P35745 ACYP2_RAT 2.00E-32 GO:0003998; GO:0005739 acylphosphatase activity; mitochondrion IPR020456; IPR027147; IPR001792; IPR017968; "Acylphosphatase-2 (EC 3.6.1.7) (Acylphosphatase, muscle type isozyme) (Acylphosphate phosphohydrolase 2)" Acyp2 Acyp Rattus norvegicus (Rat) TR27085_c0_g1_i1 P86854 PLCL_MYTGA 6.00E-14 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR27090_c1_g1_i1 Q9PTA5 PA2BD_BUNMU 6.00E-14 GO:0005509; GO:0016042; GO:0072556; GO:0004623; GO:0006644 calcium ion binding; lipid catabolic process; other organism presynaptic membrane; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Basic phospholipase A2 beta-bungarotoxin A-AL4 chain (Beta-BuTX A-AL4 chain) (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (Fragment) Bungarus multicinctus (Many-banded krait) TR27092_c1_g1_i1 Q9BSE2 TMM79_HUMAN 7.00E-06 GO:0016021 integral to membrane Transmembrane protein 79 TMEM79 Homo sapiens (Human) TR27093_c0_g1_i1 Q5BU09 EAPP_MOUSE 2.00E-39 GO:0005794; GO:0034244; GO:0005634; GO:0008284; GO:0032968 Golgi apparatus; negative regulation of transcription elongation from RNA polymerase II promoter; nucleus; positive regulation of cell proliferation; positive regulation of transcription elongation from RNA polymerase II promoter IPR019370; E2F-associated phosphoprotein (EAPP) Eapp Mus musculus (Mouse) TR27094_c1_g1_i1 P13002 ELF1_DROME 4.00E-76 GO:0007464; GO:0008362; GO:0003382; GO:0007402; GO:0005634; GO:0007009; GO:0045944; GO:0007428; GO:0042127; GO:0008360; GO:0035159; GO:0061041; GO:0042052; GO:0043565; GO:0003700; GO:0007426; GO:0006351; GO:0007419 "R3/R4 cell fate commitment; chitin-based embryonic cuticle biosynthetic process; epithelial cell morphogenesis; ganglion mother cell fate determination; nucleus; plasma membrane organization; positive regulation of transcription from RNA polymerase II promoter; primary branching, open tracheal system; regulation of cell proliferation; regulation of cell shape; regulation of tube length, open tracheal system; regulation of wound healing; rhabdomere development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; tracheal outgrowth, open tracheal system; transcription, DNA-dependent; ventral cord development" IPR007604; Protein grainyhead (DNA-binding protein ELF-1) (Element I-binding activity) (Protein grainy-head) (Transcription factor NTF-1) grh elf1 CG5058 Drosophila melanogaster (Fruit fly) TR27096_c0_g1_i1 Q60343 TRM4_METJA 2.00E-10 GO:0003723; GO:0005737; GO:0006364; GO:0016428 RNA binding; cytoplasm; rRNA processing; tRNA (cytosine-5-)-methyltransferase activity IPR001678; IPR018314; IPR011023; IPR023267; tRNA (cytosine(48)-C(5))-methyltransferase (EC 2.1.1.-) (aTrm4) (tRNA (cytosine-5-)-methyltransferase Trm4) trm4 MJ0026 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR27096_c0_g1_i2 Q96P11 NSUN5_HUMAN 7.00E-50 GO:0003723; GO:0008168 RNA binding; methyltransferase activity IPR001678; IPR023267; Putative methyltransferase NSUN5 (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein) NSUN5 WBSCR20 WBSCR20A Homo sapiens (Human) TR27097_c0_g1_i1 Q8N6F8 WBS27_HUMAN 5.00E-20 Williams-Beuren syndrome chromosomal region 27 protein WBSCR27 Homo sapiens (Human) TR27099_c1_g1_i1 O42586 PR6AB_XENLA 2.00E-23 GO:0005524; GO:0005737; GO:0017111; GO:0005634; GO:0022624; GO:0030163 ATP binding; cytoplasm; nucleoside-triphosphatase activity; nucleus; proteasome accessory complex; protein catabolic process IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 6A-B (26S proteasome AAA-ATPase subunit RPT5-B) (Proteasome 26S subunit ATPase 3-B) (Tat-binding protein 10) (TBP-10) psmc3-b tbp10 Xenopus laevis (African clawed frog) TR27099_c3_g1_i1 Q0VA52 SPA5L_XENTR 6.00E-66 GO:0005524; GO:0005737; GO:0017111 ATP binding; cytoplasm; nucleoside-triphosphatase activity IPR003593; IPR003959; IPR003960; IPR027417; Spermatogenesis-associated protein 5-like protein 1 spata5l1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR27099_c5_g1_i2 P54776 PRS6A_SOLLC 3.00E-23 GO:0005524; GO:0005737; GO:0017111; GO:0005634; GO:0000502; GO:0030163 ATP binding; cytoplasm; nucleoside-triphosphatase activity; nucleus; proteasome complex; protein catabolic process IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 6A homolog (LEMA-1) (Mg(2+)-dependent ATPase 1) (Tat-binding protein homolog 1) (TBP-1) TBP1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) TR27100_c0_g1_i1 Q6DFN1 NDUF3_XENTR 4.00E-31 GO:0005743; GO:0005634 mitochondrial inner membrane; nucleus IPR007523; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 ndufaf3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR27101_c1_g1_i1 Q5XJ85 MYD88_DANRE 6.00E-58 GO:0002755; GO:0002218; GO:0005737; GO:0006954; GO:0045087; GO:0043123; GO:0002237 MyD88-dependent toll-like receptor signaling pathway; activation of innate immune response; cytoplasm; inflammatory response; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; response to molecule of bacterial origin IPR011029; IPR000488; IPR017281; IPR000157; Myeloid differentiation primary response protein MyD88 myd88 Danio rerio (Zebrafish) (Brachydanio rerio) TR27110_c0_g1_i1 P39002 LCF3_YEAST 6.00E-07 GO:0005524; GO:0004467; GO:0031957 ATP binding; long-chain fatty acid-CoA ligase activity; very long-chain fatty acid-CoA ligase activity IPR020845; IPR000873; Long-chain-fatty-acid--CoA ligase 3 (EC 6.2.1.3) (Fatty acid activator 3) (Long-chain acyl-CoA synthetase 3) FAA3 YIL009W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR27110_c0_g2_i1 Q1ZXQ4 FCSB_DICDI 2.00E-10 GO:0005524; GO:0005783; GO:0016021; GO:0004467; GO:0005777; GO:0050766 ATP binding; endoplasmic reticulum; integral to membrane; long-chain fatty acid-CoA ligase activity; peroxisome; positive regulation of phagocytosis IPR020845; IPR000873; Fatty acyl-CoA synthetase B (EC 6.2.1.3) (Long chain fatty acyl coenzyme A-synthetase 2) (LC-FACS 2) (Long-chain-fatty-acid--CoA synthetase 2) fcsB DDB_G0269474 Dictyostelium discoideum (Slime mold) TR27110_c1_g1_i1 P41216 ACSL1_MOUSE 3.00E-44 GO:0005524; GO:0033211; GO:0005789; GO:0016021; GO:0008610; GO:0044539; GO:0004467; GO:0005741; GO:0005739; GO:0005778; GO:0005886; GO:0071902; GO:0042493; GO:0007584; GO:0034201; GO:0014070; GO:0006641; GO:0042178 ATP binding; adiponectin-mediated signaling pathway; endoplasmic reticulum membrane; integral to membrane; lipid biosynthetic process; long-chain fatty acid import; long-chain fatty acid-CoA ligase activity; mitochondrial outer membrane; mitochondrion; peroxisomal membrane; plasma membrane; positive regulation of protein serine/threonine kinase activity; response to drug; response to nutrient; response to oleic acid; response to organic cyclic compound; triglyceride metabolic process; xenobiotic catabolic process IPR020845; IPR000873; Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 1) (LACS 1) Acsl1 Acsl2 Facl2 Mus musculus (Mouse) TR27110_c3_g1_i2 P33121 ACSL1_HUMAN 4.00E-137 GO:0005524; GO:0033211; GO:0036109; GO:0005789; GO:0016021; GO:0043651; GO:0044539; GO:0004467; GO:0035338; GO:0005741; GO:0005778; GO:0005886; GO:0071902; GO:0042493; GO:0007584; GO:0034201; GO:0014070; GO:0019432; GO:0042178 ATP binding; adiponectin-mediated signaling pathway; alpha-linolenic acid metabolic process; endoplasmic reticulum membrane; integral to membrane; linoleic acid metabolic process; long-chain fatty acid import; long-chain fatty acid-CoA ligase activity; long-chain fatty-acyl-CoA biosynthetic process; mitochondrial outer membrane; peroxisomal membrane; plasma membrane; positive regulation of protein serine/threonine kinase activity; response to drug; response to nutrient; response to oleic acid; response to organic cyclic compound; triglyceride biosynthetic process; xenobiotic catabolic process IPR020845; IPR000873; Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2) ACSL1 FACL1 FACL2 LACS LACS1 LACS2 Homo sapiens (Human) TR27111_c3_g1_i1 P25943 VT2_RFVKA 4.00E-10 GO:0030683; GO:0005031 evasion or tolerance by virus of host immune response; tumor necrosis factor-activated receptor activity IPR010806; IPR011172; IPR001368; Tumor necrosis factor soluble receptor (Protein T2) s002L s002R T2 Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) TR27114_c1_g1_i1 Q9UL59 ZN214_HUMAN 1.00E-25 GO:0003677; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 214 (BWSCR2-associated zinc finger protein 1) (BAZ-1) ZNF214 BAZ1 Homo sapiens (Human) TR27114_c1_g1_i2 Q8N7K0 ZN433_HUMAN 4.00E-26 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 433 ZNF433 Homo sapiens (Human) TR27114_c1_g2_i1 Q96N20 ZN75A_HUMAN 2.00E-19 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 75A ZNF75A Homo sapiens (Human) TR27114_c2_g1_i1 Q8BU00 IKZF5_MOUSE 4.00E-08 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein Pegasus (Ikaros family zinc finger protein 5) Ikzf5 Zfpn1a5 Znfn1a5 Mus musculus (Mouse) TR27115_c0_g1_i1 Q68EH9 CRBN_DANRE 4.00E-06 GO:0004176; GO:0031464; GO:0005737; GO:0033333; GO:0060173; GO:0005634; GO:0071599; GO:0043161; GO:0016567 ATP-dependent peptidase activity; Cul4A-RING ubiquitin ligase complex; cytoplasm; fin development; limb development; nucleus; otic vesicle development; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination IPR003111; IPR015947; Protein modification; protein ubiquitination. Protein cereblon (zcrbn) crbn zgc:92404 Danio rerio (Zebrafish) (Brachydanio rerio) TR27116_c4_g1_i1 O92815 POL_WDSV 1.00E-08 GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0020002; GO:0016020; GO:0090305; GO:0006508; GO:0004523; GO:0039660; GO:0019013; GO:0008270 DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; host cell plasma membrane; membrane; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; structural constituent of virion; viral nucleocapsid; zinc ion binding IPR001584; IPR018061; IPR021109; IPR012337; IPR002156; IPR000477; IPR001878; Gag-Pol polyprotein [Cleaved into: Matrix protein p10 (MA); p20; Capsid protein p25 (CA); Nucleocapsid protein p14 (NC-pol); Protease p15 (PR) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H p90 (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase p46 (IN)] gag-pol Walleye dermal sarcoma virus (WDSV) TR27116_c6_g1_i1 Q09575 YRD6_CAEEL 1.00E-26 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR27116_c7_g1_i1 Q09575 YRD6_CAEEL 5.00E-13 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR27122_c0_g1_i1 Q8LGG8 USPAL_ARATH 1.00E-09 GO:0005886; GO:0006950 plasma membrane; response to stress IPR014729; IPR006015; IPR006016; Universal stress protein A-like protein At3g01520 F4P13.7 Arabidopsis thaliana (Mouse-ear cress) TR27123_c1_g1_i2 Q24JY3 SPC24_BOVIN 6.00E-06 GO:0031262; GO:0051301; GO:0000777; GO:0007067; GO:0005634 Ndc80 complex; cell division; condensed chromosome kinetochore; mitosis; nucleus IPR013252; Kinetochore protein Spc24 SPC24 SPBC24 Bos taurus (Bovine) TR27125_c0_g2_i2 Q9D1M4 MCA3_MOUSE 6.00E-40 GO:0006281; GO:0017101; GO:0005737; GO:0009790; GO:0008285; GO:0005634; GO:0043517; GO:0043065; GO:2001235; GO:0006412 "DNA repair; aminoacyl-tRNA synthetase multienzyme complex; cytoplasm; embryo development; negative regulation of cell proliferation; nucleus; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; translation" IPR010987; IPR004046; IPR012336; Eukaryotic translation elongation factor 1 epsilon-1 (Elongation factor p18) (Multisynthase complex auxiliary component p18) Eef1e1 Mus musculus (Mouse) TR27126_c0_g2_i1 Q7TN31 AGGF1_MOUSE 2.00E-50 GO:0001525; GO:0007155; GO:0030154; GO:0005576; GO:0003676; GO:0048471; GO:0045766; GO:0001938 angiogenesis; cell adhesion; cell differentiation; extracellular region; nucleic acid binding; perinuclear region of cytoplasm; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation IPR000253; IPR000467; IPR008984; Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (mVG5Q) Aggf1 Vg5q Mus musculus (Mouse) TR27127_c1_g1_i1 Q9P015 RM15_HUMAN 9.00E-87 GO:0015934; GO:0005739; GO:0003735; GO:0006412 large ribosomal subunit; mitochondrion; structural constituent of ribosome; translation IPR005749; IPR021131; "39S ribosomal protein L15, mitochondrial (L15mt) (MRP-L15)" MRPL15 HSPC145 Homo sapiens (Human) TR27128_c0_g1_i1 Q68EA5 ZNF57_HUMAN 7.00E-15 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 57 (Zinc finger protein 424) ZNF57 ZNF424 Homo sapiens (Human) TR27131_c2_g2_i1 B6CHA3 UHRF1_XENLA 0 GO:0007049; GO:0000791; GO:0044729; GO:0000792; GO:0016574; GO:0010216; GO:0035064; GO:0000122; GO:0000790; GO:0051865; GO:0042787; GO:0005657; GO:0006351; GO:0004842; GO:0008270 "cell cycle; euchromatin; hemi-methylated DNA-binding; heterochromatin; histone ubiquitination; maintenance of DNA methylation; methylated histone residue binding; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; protein autoubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; replication fork; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR021991; IPR015947; IPR014722; IPR003105; IPR000626; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UHRF1 (EC 6.3.2.-) (Nuclear zinc finger protein Np95) (XNp95) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) uhrf1 np95 Xenopus laevis (African clawed frog) TR27132_c0_g1_i1 Q9EPQ1 TLR1_MOUSE 1.00E-19 GO:0002755; GO:0035354; GO:0007250; GO:0071727; GO:0006952; GO:0042495; GO:0006954; GO:0045087; GO:0016021; GO:0042116; GO:0016020; GO:0045335; GO:0030670; GO:0045410; GO:0042535; GO:0050707; GO:0034130; GO:0004888; GO:0042497 MyD88-dependent toll-like receptor signaling pathway; Toll-like receptor 1-Toll-like receptor 2 protein complex; activation of NF-kappaB-inducing kinase activity; cellular response to triacyl bacterial lipopeptide; defense response; detection of triacyl bacterial lipopeptide; inflammatory response; innate immune response; integral to membrane; macrophage activation; membrane; phagocytic vesicle; phagocytic vesicle membrane; positive regulation of interleukin-6 biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; regulation of cytokine secretion; toll-like receptor 1 signaling pathway; transmembrane signaling receptor activity; triacyl lipopeptide binding IPR000483; IPR001611; IPR025875; IPR000157; IPR027190; IPR017241; Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) Tlr1 Mus musculus (Mouse) TR27132_c0_g1_i2 Q704V6 TLR6_BOVIN 1.00E-21 GO:0002755; GO:0042088; GO:0042496; GO:0006954; GO:0045087; GO:0016021; GO:0030670; GO:0005886; GO:0045410; GO:0050707; GO:0034150; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; T-helper 1 type immune response; detection of diacyl bacterial lipopeptide; inflammatory response; innate immune response; integral to membrane; phagocytic vesicle membrane; plasma membrane; positive regulation of interleukin-6 biosynthetic process; regulation of cytokine secretion; toll-like receptor 6 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR000157; IPR027187; IPR017241; Toll-like receptor 6 (CD antigen CD286) TLR6 Bos taurus (Bovine) TR27133_c0_g2_i2 A6QLH5 ERI3_BOVIN 2.00E-74 GO:0004527; GO:0046872; GO:0003676; GO:0090305 exonuclease activity; metal ion binding; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis IPR006055; IPR013520; IPR012337; ERI1 exoribonuclease 3 (EC 3.1.-.-) (Prion interactor 1) (Prion protein-interacting protein) ERI3 PINT1 PRNPIP PRNPIP1 Bos taurus (Bovine) TR27135_c2_g1_i1 Q91880 SUH_XENLA 0 GO:0000978; GO:0000982; GO:0005737; GO:0007275; GO:0005634; GO:0007221 RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity; cytoplasm; multicellular organismal development; nucleus; positive regulation of transcription of Notch receptor target IPR015350; IPR013783; IPR014756; IPR002909; IPR015351; IPR008967; Suppressor of hairless protein homolog (X-Su(H)) rbpj rbpsuh suh Xenopus laevis (African clawed frog) TR27136_c0_g1_i1 Q8BNA6 FAT3_MOUSE 4.00E-12 GO:0005509; GO:0007156; GO:0016021; GO:0007275; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; multicellular organismal development; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Protocadherin Fat 3 (FAT tumor suppressor homolog 3) Fat3 Gm1132 Gm510 Mus musculus (Mouse) TR27139_c3_g1_i1 O70566 DIAP2_MOUSE 2.00E-90 GO:0003779; GO:0030041; GO:0030154; GO:0007275; GO:0048477 actin binding; actin filament polymerization; cell differentiation; multicellular organismal development; oogenesis IPR016024; IPR014767; IPR010465; IPR015425; IPR010472; IPR010473; IPR014768; Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) (mDia3) Diaph2 Diap2 Mus musculus (Mouse) TR27140_c0_g1_i1 P78976 SAR1_HYPJE 8.00E-18 GO:0012507; GO:0005525; GO:0000139; GO:0005789; GO:0016787; GO:0006886; GO:0016192 ER to Golgi transport vesicle membrane; GTP binding; Golgi membrane; endoplasmic reticulum membrane; hydrolase activity; intracellular protein transport; vesicle-mediated transport IPR027417; IPR005225; IPR006689; IPR006687; Small COPII coat GTPase sar1 (EC 3.6.5.-) sar1 Hypocrea jecorina (Trichoderma reesei) TR27140_c0_g1_i2 Q5M9P8 ARL6_DANRE 2.00E-84 GO:0005525; GO:0070121; GO:0042384; GO:0035085; GO:0060170; GO:0007368; GO:0032402; GO:0046872; GO:0005932; GO:0033339; GO:0007264; GO:0007601 GTP binding; Kupffer's vesicle development; cilium assembly; cilium axoneme; cilium membrane; determination of left/right symmetry; melanosome transport; metal ion binding; microtubule basal body; pectoral fin development; small GTPase mediated signal transduction; visual perception IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 6 arl6 si:dkey-24h22.2 zgc:101762 Danio rerio (Zebrafish) (Brachydanio rerio) TR27140_c0_g2_i1 Q5M9P8 ARL6_DANRE 3.00E-07 GO:0005525; GO:0070121; GO:0042384; GO:0035085; GO:0060170; GO:0007368; GO:0032402; GO:0046872; GO:0005932; GO:0033339; GO:0007264; GO:0007601 GTP binding; Kupffer's vesicle development; cilium assembly; cilium axoneme; cilium membrane; determination of left/right symmetry; melanosome transport; metal ion binding; microtubule basal body; pectoral fin development; small GTPase mediated signal transduction; visual perception IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 6 arl6 si:dkey-24h22.2 zgc:101762 Danio rerio (Zebrafish) (Brachydanio rerio) TR27143_c0_g1_i2 Q6AXP4 CB081_RAT 1.00E-18 IPR028042; Uncharacterized protein C2orf81 homolog Rattus norvegicus (Rat) TR27144_c0_g2_i1 Q8HYL8 ACOX1_PHACI 1.00E-145 GO:0003995; GO:0003997; GO:0033540; GO:0019395; GO:0050660; GO:0006091; GO:0005777; GO:0006693 acyl-CoA dehydrogenase activity; acyl-CoA oxidase activity; fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid oxidation; flavin adenine dinucleotide binding; generation of precursor metabolites and energy; peroxisome; prostaglandin metabolic process IPR006091; IPR012258; IPR002655; IPR009075; IPR013786; IPR009100; Lipid metabolism; peroxisomal fatty acid beta-oxidation. Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) ACOX1 Phascolarctos cinereus (Koala) TR27144_c0_g5_i1 Q15067 ACOX1_HUMAN 3.00E-29 GO:0071949; GO:0003995; GO:0003997; GO:0036109; GO:0033540; GO:0005504; GO:0019395; GO:0050660; GO:0006091; GO:0055088; GO:0005739; GO:0016401; GO:0005782; GO:0005778; GO:0016559; GO:2000189; GO:0006693; GO:0007283; GO:0000038 FAD binding; acyl-CoA dehydrogenase activity; acyl-CoA oxidase activity; alpha-linolenic acid metabolic process; fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid binding; fatty acid oxidation; flavin adenine dinucleotide binding; generation of precursor metabolites and energy; lipid homeostasis; mitochondrion; palmitoyl-CoA oxidase activity; peroxisomal matrix; peroxisomal membrane; peroxisome fission; positive regulation of cholesterol homeostasis; prostaglandin metabolic process; spermatogenesis; very long-chain fatty acid metabolic process IPR006091; IPR012258; IPR002655; IPR009075; IPR013786; IPR009100; Lipid metabolism; peroxisomal fatty acid beta-oxidation. Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX) ACOX1 ACOX Homo sapiens (Human) TR27145_c0_g1_i1 Q0EEE2 PTHD3_MOUSE 2.00E-43 GO:0008158; GO:0016021 hedgehog receptor activity; integral to membrane IPR003392; IPR000731; Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) TR27146_c0_g3_i2 Q5NDL9 EOGT_CANFA 0 GO:0005788; GO:0016262; GO:0006493 endoplasmic reticulum lumen; protein N-acetylglucosaminyltransferase activity; protein O-linked glycosylation IPR007657; EGF domain-specific O-linked N-acetylglucosamine transferase (EC 2.4.1.255) (Extracellular O-linked N-acetylglucosamine transferase) EOGT AER61 Canis familiaris (Dog) (Canis lupus familiaris) TR27146_c0_g3_i3 Q5NDE3 GTDC2_TETNG 3.00E-09 GO:0008375; GO:0005783; GO:0005789; GO:0016021; GO:0006493 acetylglucosaminyltransferase activity; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; protein O-linked glycosylation IPR003961; IPR007657; IPR013783; Protein modification; protein glycosylation. "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2) (EC 2.4.1.-) (Extracellular O-linked N-acetylglucosamine transferase-like) (Glycosyltransferase-like domain-containing protein 2)" pomgnt2 ago61 gtdc2 GSTENG00012312001 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) TR27149_c0_g1_i1 P28648 CD63_RAT 6.00E-22 GO:0030855; GO:0016021; GO:0005765; GO:0005764; GO:0010633; GO:0005886; GO:0045785; GO:0045807; GO:0043234; GO:0032403; GO:0030658 Q03348; Q9WUD9 epithelial cell differentiation; integral to membrane; lysosomal membrane; lysosome; negative regulation of epithelial cell migration; plasma membrane; positive regulation of cell adhesion; positive regulation of endocytosis; protein complex; protein complex binding; transport vesicle membrane IPR000301; IPR018499; IPR018503; IPR008952; CD63 antigen (Mast cell antigen AD1) (CD antigen CD63) Cd63 Rattus norvegicus (Rat) TR27152_c0_g1_i1 P40656 SOX14_DROME 2.00E-39 GO:0008301; GO:0048813; GO:0007552; GO:0016322; GO:0005634; GO:0006357; GO:0043565; GO:0006351 "DNA binding, bending; dendrite morphogenesis; metamorphosis; neuron remodeling; nucleus; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent" IPR009071; Putative transcription factor SOX-14 Sox14 CG3090 Drosophila melanogaster (Fruit fly) TR27153_c5_g1_i1 Q920H4 ACM5_MOUSE 5.00E-06 GO:0016907; GO:0030054; GO:0015872; GO:0016934; GO:0001696; GO:0005887; GO:0045211; GO:0060304; GO:0019226 G-protein coupled acetylcholine receptor activity; cell junction; dopamine transport; extracellular-glycine-gated chloride channel activity; gastric acid secretion; integral to plasma membrane; postsynaptic membrane; regulation of phosphatidylinositol dephosphorylation; transmission of nerve impulse IPR000276; IPR017452; IPR000502; IPR000995; Muscarinic acetylcholine receptor M5 Chrm5 Mus musculus (Mouse) TR27153_c5_g2_i1 O77245 E75_METEN 2.00E-46 GO:0005634; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Nuclear hormone receptor E75 (Nuclear receptor subfamily 1 group D member 3) E75 NR1D3 Metapenaeus ensis (Greasyback shrimp) (Sand shrimp) TR27153_c5_g2_i2 P17671 E75BC_DROME 5.00E-24 GO:0003677; GO:0019730; GO:0018990; GO:0035072; GO:0020037; GO:0004879; GO:0005634; GO:0048477; GO:0007553; GO:0043565; GO:0003707; GO:0004887; GO:0008270 "DNA binding; antimicrobial humoral response; ecdysis, chitin-based cuticle; ecdysone-mediated induction of salivary gland cell autophagic cell death; heme binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleus; oogenesis; regulation of ecdysteroid metabolic process; sequence-specific DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001728; IPR001628; IPR013088; "Ecdysone-induced protein 75B, isoforms C/D (E75-A) (Nuclear receptor subfamily 1 group D member 3, isoforms C/D)" Eip75B NR1D3 CG8127 Drosophila melanogaster (Fruit fly) TR27154_c0_g1_i1 O95497 VNN1_HUMAN 2.00E-128 GO:0034235; GO:0002526; GO:0031225; GO:0016337; GO:0006928; GO:0002544; GO:0045087; GO:0016021; GO:0043066; GO:1902176; GO:0017159; GO:0015939; GO:0005886; GO:0033089; GO:0006979 GPI anchor binding; acute inflammatory response; anchored to membrane; cell-cell adhesion; cellular component movement; chronic inflammatory response; innate immune response; integral to membrane; negative regulation of apoptotic process; negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress; pantetheine hydrolase activity; pantothenate metabolic process; plasma membrane; positive regulation of T cell differentiation in thymus; response to oxidative stress IPR012101; IPR003010; Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Tiff66) (Vascular non-inflammatory molecule 1) (Vanin-1) VNN1 Homo sapiens (Human) TR27157_c0_g1_i2 Q96EL3 RM53_HUMAN 8.00E-11 GO:0005739; GO:0005840 mitochondrion; ribosome IPR019716; "39S ribosomal protein L53, mitochondrial (L53mt) (MRP-L53)" MRPL53 Homo sapiens (Human) TR27163_c10_g2_i1 O60522 TDRD6_HUMAN 2.00E-09 GO:0043186; GO:0033391; GO:0005783; GO:0007281; GO:0007275; GO:0007283 P granule; chromatoid body; endoplasmic reticulum; germ cell development; multicellular organismal development; spermatogenesis IPR002999; Tudor domain-containing protein 6 (Antigen NY-CO-45) (Cancer/testis antigen 41.2) (CT41.2) TDRD6 Homo sapiens (Human) TR27163_c8_g1_i1 Q4R3G4 RNF17_MACFA 5.00E-23 GO:0030154; GO:0005737; GO:0016788; GO:0007275; GO:0003676; GO:0005634; GO:0007283; GO:0008270 "cell differentiation; cytoplasm; hydrolase activity, acting on ester bonds; multicellular organismal development; nucleic acid binding; nucleus; spermatogenesis; zinc ion binding" IPR016071; IPR002999; IPR001841; IPR017907; RING finger protein 17 RNF17 QtsA-12695 QtsA-12850 QtsA-15623 QtsA-17057 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR27164_c5_g1_i1 Q57997 Y577_METJA 5.00E-08 GO:0005524; GO:0005737; GO:0006950 ATP binding; cytoplasm; response to stress IPR014729; IPR006015; IPR006016; Universal stress protein MJ0577 (USP MJ0577) MJ0577 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR27165_c0_g1_i1 O79428 NU2M_RABIT 5.00E-21 GO:0008137; GO:0016021; GO:0006120; GO:0005747 "NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I" IPR010933; IPR001750; IPR003917; NADH-ubiquinone oxidoreductase chain 2 (EC 1.6.5.3) (NADH dehydrogenase subunit 2) MT-ND2 MTND2 NADH2 ND2 Oryctolagus cuniculus (Rabbit) TR27171_c0_g2_i1 Q3M890 HCP_ANAVT 3.00E-07 GO:0051539; GO:0005737; GO:0050418; GO:0046872 "4 iron, 4 sulfur cluster binding; cytoplasm; hydroxylamine reductase activity; metal ion binding" IPR004137; IPR010048; IPR011254; IPR016099; IPR016100; Hydroxylamine reductase (EC 1.7.-.-) (Hybrid-cluster protein) (HCP) hcp Ava_3188 Anabaena variabilis (strain ATCC 29413 / PCC 7937) TR27172_c2_g2_i1 Q9UPN9 TRI33_HUMAN 6.00E-12 GO:0003677; GO:0030514; GO:0000122; GO:0005654; GO:0017015; GO:0006367; GO:0007179; GO:0004842; GO:0008270 Q15796; Q13485 DNA binding; negative regulation of BMP signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; regulation of transforming growth factor beta receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) TRIM33 KIAA1113 RFG7 TIF1G Homo sapiens (Human) TR27178_c5_g1_i1 Q6ZPS6 AKIB1_MOUSE 2.00E-57 GO:0008270 zinc ion binding IPR002110; IPR020683; IPR003903; IPR002867; IPR001841; IPR013083; Ankyrin repeat and IBR domain-containing protein 1 Ankib1 Kiaa1386 Mus musculus (Mouse) TR27189_c0_g1_i1 P83829 IFT81_RAT 0 GO:0030154; GO:0007275; GO:0007283 cell differentiation; multicellular organismal development; spermatogenesis Intraflagellar transport protein 81 homolog (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1) Ift81 Cdv1 Rattus norvegicus (Rat) TR27191_c1_g1_i1 Q922B6 TRAF7_MOUSE 1.00E-10 GO:0000185; GO:0016023; GO:0097194; GO:0005886; GO:0043410; GO:0006355; GO:0006351; GO:0000151; GO:0004842; GO:0008270 "activation of MAPKKK activity; cytoplasmic membrane-bounded vesicle; execution phase of apoptosis; plasma membrane; positive regulation of MAPK cascade; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin ligase complex; ubiquitin-protein ligase activity; zinc ion binding" IPR020472; IPR013323; IPR008974; IPR015943; IPR001680; IPR019775; IPR017986; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor-associated factor 7) Traf7 Mus musculus (Mouse) TR27191_c3_g1_i1 Q9Y0T2 FBXA_DICDI 8.00E-06 GO:0019005; GO:0031154; GO:0008289; GO:0045595; GO:0030435; GO:0006511; GO:0004842 SCF ubiquitin ligase complex; culmination involved in sorocarp development; lipid binding; regulation of cell differentiation; sporulation resulting in formation of a cellular spore; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR001810; IPR023393; IPR002913; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein A (F-box protein A) (Protein cheater A) fbxA chtA DDB_G0276887 Dictyostelium discoideum (Slime mold) TR27191_c4_g1_i1 P90648 MHCKB_DICDI 1.00E-27 GO:0005524; GO:0005826; GO:0000281; GO:0031037; GO:0016905; GO:0018107; GO:0046777 ATP binding; actomyosin contractile ring; mitotic cytokinesis; myosin II filament disassembly; myosin heavy chain kinase activity; peptidyl-threonine phosphorylation; protein autophosphorylation IPR020472; IPR011009; IPR004166; IPR015943; IPR001680; IPR019775; IPR017986; Myosin heavy chain kinase B (MHCK-B) (EC 2.7.11.7) mhkB mhckB DDB_G0289115 Dictyostelium discoideum (Slime mold) TR27191_c4_g1_i2 Q6Q0C0 TRAF7_HUMAN 5.00E-44 GO:0000185; GO:0016023; GO:0097194; GO:0043231; GO:0005886; GO:0043410; GO:0006355; GO:0006351; GO:0000151; GO:0004842; GO:0008270 Q99759; Q9ERK0 "activation of MAPKKK activity; cytoplasmic membrane-bounded vesicle; execution phase of apoptosis; intracellular membrane-bounded organelle; plasma membrane; positive regulation of MAPK cascade; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin ligase complex; ubiquitin-protein ligase activity; zinc ion binding" IPR020472; IPR013323; IPR008974; IPR015943; IPR001680; IPR019775; IPR017986; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRAF7 (EC 6.3.2.-) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (TNF receptor-associated factor 7) TRAF7 RFWD1 RNF119 Homo sapiens (Human) TR27196_c0_g1_i1 Q7T0Q5 NOL10_XENLA 0 GO:0005730 nucleolus IPR012580; IPR015943; IPR001680; IPR017986; Nucleolar protein 10 nol10 Xenopus laevis (African clawed frog) TR27198_c0_g1_i1 P51400 RED1_RAT 5.00E-10 GO:0006396; GO:0006382; GO:0003726; GO:0003725; GO:0016556; GO:0006397; GO:0046872; GO:0030336; GO:0008285; GO:0044387; GO:0005730; GO:0005654; GO:0045070; GO:0051726 RNA processing; adenosine to inosine editing; double-stranded RNA adenosine deaminase activity; double-stranded RNA binding; mRNA modification; mRNA processing; metal ion binding; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of protein kinase activity by regulation of protein phosphorylation; nucleolus; nucleoplasm; positive regulation of viral genome replication; regulation of cell cycle IPR002466; IPR014720; Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) Adarb1 Red1 Rattus norvegicus (Rat) TR27200_c0_g1_i2 P38977 ANTA_HYDVU 3.00E-06 GO:0007596; GO:0005576; GO:0008201; GO:0004867 blood coagulation; extracellular region; heparin binding; serine-type endopeptidase inhibitor activity IPR004094; IPR011061; Antistasin (ATS) (Blood coagulation factor Xa/proclotting enzyme inhibitor) Hydra vulgaris (Hydra) (Hydra attenuata) TR27202_c3_g1_i1 P18172 DHGL_DROPS 8.00E-42 GO:0006066; GO:0008812; GO:0005576; GO:0050660 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR27203_c0_g1_i1 Q90YI8 TAL1_TAKRU 3.00E-24 GO:0003677; GO:0001525; GO:0048844; GO:0060216; GO:0060214; GO:0030218; GO:0060217; GO:0060218; GO:0005634; GO:0006355; GO:0006351; GO:0001570 "DNA binding; angiogenesis; artery morphogenesis; definitive hemopoiesis; endocardium formation; erythrocyte differentiation; hemangioblast cell differentiation; hematopoietic stem cell differentiation; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; vasculogenesis" IPR011598; T-cell acute lymphocytic leukemia protein 1 (TAL-1) (FrSCL) (Stem cell protein) tal1 scl Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR27205_c0_g1_i1 Q9VZZ4 PXDN_DROME 1.00E-08 GO:0030198; GO:0020037; GO:0042744; GO:0046872; GO:0004601; GO:0006909; GO:0005578 extracellular matrix organization; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity; phagocytosis; proteinaceous extracellular matrix IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR003591; IPR000372; IPR001007; Peroxidasin (EC 1.11.1.7) Pxn CG12002 Drosophila melanogaster (Fruit fly) TR27205_c2_g1_i3 Q9IBG7 KCP_XENLA 2.00E-66 GO:0005576 extracellular region IPR008985; IPR001791; IPR002919; IPR014853; IPR001007; IPR001846; Kielin/chordin-like protein (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin) kcp crim2 Xenopus laevis (African clawed frog) TR27205_c3_g1_i1 Q8N8U9 BMPER_HUMAN 4.00E-45 GO:0002043; GO:0042118; GO:0005615; GO:0048839; GO:0030514; GO:0070374; GO:0010594; GO:0060393; GO:0001657 blood vessel endothelial cell proliferation involved in sprouting angiogenesis; endothelial cell activation; extracellular space; inner ear development; negative regulation of BMP signaling pathway; positive regulation of ERK1 and ERK2 cascade; regulation of endothelial cell migration; regulation of pathway-restricted SMAD protein phosphorylation; ureteric bud development IPR002919; IPR014853; IPR001007; IPR001846; BMP-binding endothelial regulator protein (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2) BMPER KIAA1965 Homo sapiens (Human) TR27206_c0_g1_i2 Q2HJH8 CK070_BOVIN 2.00E-93 Uncharacterized protein C11orf70 homolog Bos taurus (Bovine) TR27216_c0_g1_i3 P20481 BUCC_APLCA 1.00E-25 GO:0005576; GO:0007218 extracellular region; neuropeptide signaling pathway Buccalin [Cleaved into: Buccalin-D; Buccalin-E; Buccalin-F; Buccalin-G; Buccalin-H; Buccalin-A; Buccalin-I; Buccalin-J; Buccalin-K; Buccalin-L; Buccalin-B (BUCb); Buccalin-M; Buccalin gene-predicted acidic peptide A (BGPAP A); Buccalin-N; Buccalin-O; Buccalin-P; Buccalin-Q; Buccalin-R; Buccalin-C; Buccalin-S; Buccalin gene-predicted acidic peptide B (BGPAP B)] Aplysia californica (California sea hare) TR27218_c1_g1_i1 Q13938 CAYP1_HUMAN 2.00E-63 GO:0005509; GO:0005737; GO:0035556; GO:0005634; GO:0005886 calcium ion binding; cytoplasm; intracellular signal transduction; nucleus; plasma membrane IPR011992; IPR018247; IPR002048; Calcyphosin (Calcyphosine) CAPS Homo sapiens (Human) TR27219_c1_g1_i1 Q8CEE6 PASK_MOUSE 6.00E-112 GO:0005524; GO:0005737; GO:0045719; GO:0005634; GO:0035091; GO:0046777; GO:0004674; GO:2000505; GO:0070092; GO:0043576; GO:0004871 ATP binding; cytoplasm; negative regulation of glycogen biosynthetic process; nucleus; phosphatidylinositol binding; protein autophosphorylation; protein serine/threonine kinase activity; regulation of energy homeostasis; regulation of glucagon secretion; regulation of respiratory gaseous exchange; signal transducer activity IPR011009; IPR000014; IPR000719; IPR017441; IPR002290; IPR008271; PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (EC 2.7.11.1) Pask Kiaa0135 Mus musculus (Mouse) TR27220_c4_g1_i1 A2CI34 DUSTY_PIMPR 9.00E-21 GO:0005524; GO:0005737; GO:0018108; GO:0004674; GO:0004712; GO:0004713 ATP binding; cytoplasm; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (Receptor-interacting serine/threonine-protein kinase 5) dstyk ripk5 Pimephales promelas (Fathead minnow) TR27223_c0_g1_i1 Q5NVK7 SPOP_PONAB 2.00E-11 GO:0031463; GO:0016607; GO:0005634; GO:0043161; GO:0016567 Cul3-RING ubiquitin ligase complex; nuclear speck; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination IPR000210; IPR011333; IPR013069; IPR002083; IPR008974; Protein modification; protein ubiquitination. Speckle-type POZ protein SPOP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR27223_c0_g1_i4 Q5U504 KBTB5_XENLA 4.00E-07 GO:0007275; GO:0030017 multicellular organismal development; sarcomere IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 40 (Kelch repeat and BTB domain-containing protein 5) klhl40 kbtbd5 Xenopus laevis (African clawed frog) TR27223_c0_g1_i6 Q8K2J9 BTBD6_MOUSE 4.00E-21 GO:0000932 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6 Btbd6 Mus musculus (Mouse) TR27225_c0_g1_i1 Q5RK00 RM46_RAT 6.00E-29 GO:0016787; GO:0005739; GO:0005840 hydrolase activity; mitochondrion; ribosome IPR015797; IPR021757; "39S ribosomal protein L46, mitochondrial (L46mt) (MRP-L46)" Mrpl46 Rattus norvegicus (Rat) TR27227_c0_g1_i1 Q00PJ9 CAV1_ATEAB 4.00E-29 GO:0000139; GO:0031295; GO:0005901; GO:0005768 Golgi membrane; T cell costimulation; caveola; endosome IPR001612; IPR015504; IPR018361; Caveolin-1 CAV1 Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog) TR27228_c0_g1_i2 Q32P65 MIMIT_BOVIN 8.00E-15 GO:0005739 mitochondrion "Mimitin, mitochondrial (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2) (NDUFA12-like protein)" NDUFAF2 NDUFA12L Bos taurus (Bovine) TR27230_c0_g1_i1 Q6NWH5 TMM11_DANRE 2.00E-31 GO:0031305; GO:0007005 integral to mitochondrial inner membrane; mitochondrion organization IPR026120; "Transmembrane protein 11, mitochondrial" tmem11 zgc:110086 Danio rerio (Zebrafish) (Brachydanio rerio) TR27230_c0_g1_i2 A2BD92 TM11A_XENLA 2.00E-29 GO:0031305; GO:0007005 integral to mitochondrial inner membrane; mitochondrion organization IPR026120; "Transmembrane protein 11-A, mitochondrial" tmem11-a tmem11 Xenopus laevis (African clawed frog) TR27235_c3_g1_i1 P98164 LRP2_HUMAN 2.00E-11 GO:0005794; GO:0016324; GO:0031526; GO:0005509; GO:0008283; GO:0005905; GO:0030139; GO:0005783; GO:0005768; GO:0030900; GO:0016021; GO:0005765; GO:0007603; GO:0006486; GO:0006898; GO:0001523; GO:0042359 "Golgi apparatus; apical plasma membrane; brush border membrane; calcium ion binding; cell proliferation; coated pit; endocytic vesicle; endoplasmic reticulum; endosome; forebrain development; integral to membrane; lysosomal membrane; phototransduction, visible light; protein glycosylation; receptor-mediated endocytosis; retinoid metabolic process; vitamin D metabolic process" IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; IPR019825; Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) LRP2 Homo sapiens (Human) TR27237_c0_g1_i1 Q5RB31 SC61B_PONAB 3.00E-34 GO:0030433; GO:0031205; GO:0016021; GO:0000060; GO:0030970 "ER-associated protein catabolic process; endoplasmic reticulum Sec complex; integral to membrane; protein import into nucleus, translocation; retrograde protein transport, ER to cytosol" IPR016482; Protein transport protein Sec61 subunit beta SEC61B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR27241_c1_g1_i1 Q9STY0 PX11B_ARATH 6.00E-06 GO:0042802; GO:0005779; GO:0005778; GO:0016559; GO:0044375 identical protein binding; integral to peroxisomal membrane; peroxisomal membrane; peroxisome fission; regulation of peroxisome size IPR008733; Peroxisomal membrane protein 11B (Peroxin-11B) (AtPEX11b) PEX11B PEX11-4 At3g47430 T21L8.180 Arabidopsis thaliana (Mouse-ear cress) TR27241_c1_g1_i2 Q9Z210 PX11B_MOUSE 2.00E-31 GO:0005779; GO:0005739; GO:0016559; GO:0007031; GO:0043234; GO:0051260; GO:0044375; GO:0007165 integral to peroxisomal membrane; mitochondrion; peroxisome fission; peroxisome organization; protein complex; protein homooligomerization; regulation of peroxisome size; signal transduction IPR008733; Peroxisomal membrane protein 11B (Peroxin-11B) (Peroxisomal biogenesis factor 11B) (Protein PEX11 homolog beta) (PEX11-beta) Pex11b Mus musculus (Mouse) TR27242_c1_g1_i1 Q9BX70 BTBD2_HUMAN 3.00E-12 GO:0000932 Q7L5N1; P04637 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) TR27242_c1_g1_i2 Q6GR09 SPOPL_XENLA 3.00E-07 GO:0031463; GO:0031397; GO:0005634; GO:0043161; GO:0016567 Cul3-RING ubiquitin ligase complex; negative regulation of protein ubiquitination; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination IPR000210; IPR011333; IPR013069; IPR002083; IPR008974; Protein modification; protein ubiquitination. Speckle-type POZ protein-like spopl Xenopus laevis (African clawed frog) TR27244_c0_g1_i1 Q7KQL8 THIO_PLAF7 3.00E-25 GO:0045454; GO:0006662; GO:0015035 cell redox homeostasis; glycerol ether metabolic process; protein disulfide oxidoreductase activity IPR005746; IPR012336; IPR017937; IPR013766; Thioredoxin (Trx) PF14_0545 Plasmodium falciparum (isolate 3D7) TR27245_c1_g1_i1 B1AT66 MOT7_MOUSE 3.00E-07 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 7 (MCT 7) (Monocarboxylate transporter 6) (MCT 6) (Solute carrier family 16 member 6) Slc16a6 Mct7 Mus musculus (Mouse) TR27245_c2_g1_i1 Q8K1C7 MOT14_MOUSE 4.00E-12 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) Slc16a14 Mct14 Mus musculus (Mouse) TR27245_c5_g1_i1 Q5M8Z2 PREY_XENTR 1.00E-17 GO:0005739 mitochondrion IPR005651; "Protein preY, mitochondrial" pyurf pigy prey Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR27247_c0_g1_i1 P45672 DUS_AZOBR 6.00E-36 GO:0050660; GO:0017150; GO:0002943 flavin adenine dinucleotide binding; tRNA dihydrouridine synthase activity; tRNA dihydrouridine synthesis IPR013785; IPR024036; IPR004652; IPR001269; IPR018517; Probable tRNA-dihydrouridine synthase (EC 1.-.-.-) dus Azospirillum brasilense TR27247_c0_g1_i2 Q7ZWS1 DUS3L_XENLA 0 GO:0050660; GO:0046872; GO:0017150; GO:0002943 flavin adenine dinucleotide binding; metal ion binding; tRNA dihydrouridine synthase activity; tRNA dihydrouridine synthesis IPR013785; IPR001269; IPR018517; IPR000571; tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3-like) dus3l Xenopus laevis (African clawed frog) TR27247_c0_g1_i4 Q54CU9 DUS3L_DICDI 4.00E-144 GO:0005737; GO:0050660; GO:0046872; GO:0005634; GO:0017150 cytoplasm; flavin adenine dinucleotide binding; metal ion binding; nucleus; tRNA dihydrouridine synthase activity IPR013785; IPR001269; IPR018517; IPR000571; tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3-like) dus3l DDB_G0292686 Dictyostelium discoideum (Slime mold) TR2725_c0_g2_i1 Q4V817 CB068_XENLA 8.00E-19 IPR018888; UPF0561 protein C2orf68 homolog Xenopus laevis (African clawed frog) TR27250_c0_g1_i3 P29371 NK3R_HUMAN 4.00E-16 GO:0007568; GO:0042538; GO:0005887; GO:0005634; GO:0045777; GO:0010460; GO:0070474; GO:0042053; GO:0060259; GO:0042220; GO:0032355; GO:0043278; GO:0004995 Q9UHF0 aging; hyperosmotic salinity response; integral to plasma membrane; nucleus; positive regulation of blood pressure; positive regulation of heart rate; positive regulation of uterine smooth muscle contraction; regulation of dopamine metabolic process; regulation of feeding behavior; response to cocaine; response to estradiol stimulus; response to morphine; tachykinin receptor activity IPR000276; IPR017452; IPR001681; IPR001013; Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3) TACR3 NK3R TAC3R Homo sapiens (Human) TR27252_c2_g1_i1 P55210 CASP7_HUMAN 9.00E-76 GO:0008635; GO:0004190; GO:0006921; GO:0004197; GO:0005829; GO:0007507; GO:0097193; GO:0005654; GO:0043525; GO:0016485; GO:0006508; GO:0001836; GO:0009411 Q13490; Q13177; P17405; P98170 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; aspartic-type endopeptidase activity; cellular component disassembly involved in execution phase of apoptosis; cysteine-type endopeptidase activity; cytosol; heart development; intrinsic apoptotic signaling pathway; nucleoplasm; positive regulation of neuron apoptotic process; protein processing; proteolysis; release of cytochrome c from mitochondria; response to UV IPR015471; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Homo sapiens (Human) TR27252_c2_g1_i2 Q98943 CASP2_CHICK 3.00E-32 GO:0006915; GO:0004197; GO:0005622; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; intracellular; proteolysis; regulation of apoptotic process IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) TR27253_c0_g1_i1 O14681 EI24_HUMAN 4.00E-89 GO:0006915; GO:0006914; GO:0005789; GO:0016021; GO:0030308; GO:0031965; GO:0042493 apoptotic process; autophagy; endoplasmic reticulum membrane; integral to membrane; negative regulation of cell growth; nuclear membrane; response to drug IPR009890; Etoposide-induced protein 2.4 homolog (p53-induced gene 8 protein) EI24 PIG8 Homo sapiens (Human) TR27256_c0_g1_i1 O43247 TEX33_HUMAN 7.00E-07 Testis-expressed sequence 33 protein TEX33 C22orf33 EAN57 Homo sapiens (Human) TR27258_c0_g1_i1 O01666 ATPG_DROME 1.00E-125 GO:0015986; GO:0005811; GO:0005743; GO:0006909; GO:0046933; GO:0045261; GO:0046961 "ATP synthesis coupled proton transport; lipid particle; mitochondrial inner membrane; phagocytosis; proton-transporting ATP synthase activity, rotational mechanism; proton-transporting ATP synthase complex, catalytic core F(1); proton-transporting ATPase activity, rotational mechanism" IPR000131; IPR023632; IPR023633; "ATP synthase subunit gamma, mitochondrial (F-ATPase gamma subunit)" ATPsyn-gamma CG7610 Drosophila melanogaster (Fruit fly) TR27258_c0_g2_i1 P49377 ATPG_KLULA 3.00E-62 GO:0015986; GO:0005743; GO:0046933; GO:0045261; GO:0046961 "ATP synthesis coupled proton transport; mitochondrial inner membrane; proton-transporting ATP synthase activity, rotational mechanism; proton-transporting ATP synthase complex, catalytic core F(1); proton-transporting ATPase activity, rotational mechanism" IPR000131; IPR023632; IPR023633; "ATP synthase subunit gamma, mitochondrial (F-ATPase gamma subunit)" ATP3 MGI5 KLLA0B06886g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR27259_c0_g1_i1 B3E858 RL17_GEOLS 6.00E-15 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000456; 50S ribosomal protein L17 rplQ Glov_1374 Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ) TR27259_c0_g1_i2 Q3T0L3 RM17_BOVIN 4.00E-33 GO:0005739; GO:0005840; GO:0003735; GO:0006412 mitochondrion; ribosome; structural constituent of ribosome; translation IPR000456; "39S ribosomal protein L17, mitochondrial (L17mt) (MRP-L17)" MRPL17 Bos taurus (Bovine) TR27260_c0_g1_i2 P79222 CALCR_RABIT 3.00E-68 GO:0007202; GO:0032841; GO:0004948; GO:0016021; GO:0005886; GO:0045762 activation of phospholipase C activity; calcitonin binding; calcitonin receptor activity; integral to membrane; plasma membrane; positive regulation of adenylate cyclase activity IPR003287; IPR017981; IPR001688; IPR001879; IPR000832; IPR017983; Calcitonin receptor (CT-R) CALCR Oryctolagus cuniculus (Rabbit) TR27262_c2_g1_i1 P97467 AMD_MOUSE 8.00E-21 GO:0031418; GO:0005507; GO:0005829; GO:0005887; GO:0006518; GO:0004598; GO:0004504; GO:0030658 L-ascorbic acid binding; copper ion binding; cytosol; integral to plasma membrane; peptide metabolic process; peptidylamidoglycolate lyase activity; peptidylglycine monooxygenase activity; transport vesicle membrane IPR011042; IPR014784; IPR020611; IPR014783; IPR000323; IPR001258; IPR013017; IPR000720; IPR008977; Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)] Pam Mus musculus (Mouse) TR27262_c2_g1_i3 P19021 AMD_HUMAN 2.00E-21 GO:0031418; GO:0005509; GO:0009986; GO:0006464; GO:0007417; GO:0005507; GO:0005576; GO:0007507; GO:0016021; GO:0060173; GO:0001676; GO:0060135; GO:0043005; GO:0042476; GO:0022602; GO:0001519; GO:0006518; GO:0004598; GO:0004504; GO:0043204; GO:0048471; GO:0005886; GO:0018032; GO:0051260; GO:0032956; GO:0050708; GO:0006357; GO:0046688; GO:0042493; GO:0032355; GO:0051384; GO:0001666; GO:0009268; GO:0030141; GO:0030667; GO:0009404; GO:0005802; GO:0008270 L-ascorbic acid binding; calcium ion binding; cell surface; cellular protein modification process; central nervous system development; copper ion binding; extracellular region; heart development; integral to membrane; limb development; long-chain fatty acid metabolic process; maternal process involved in female pregnancy; neuron projection; odontogenesis; ovulation cycle process; peptide amidation; peptide metabolic process; peptidylamidoglycolate lyase activity; peptidylglycine monooxygenase activity; perikaryon; perinuclear region of cytoplasm; plasma membrane; protein amidation; protein homooligomerization; regulation of actin cytoskeleton organization; regulation of protein secretion; regulation of transcription from RNA polymerase II promoter; response to copper ion; response to drug; response to estradiol stimulus; response to glucocorticoid stimulus; response to hypoxia; response to pH; secretory granule; secretory granule membrane; toxin metabolic process; trans-Golgi network; zinc ion binding IPR011042; IPR014784; IPR020611; IPR014783; IPR000323; IPR001258; IPR013017; IPR000720; IPR008977; Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)] PAM Homo sapiens (Human) TR27263_c0_g1_i3 Q6P1E8 EFCB6_MOUSE 2.00E-07 GO:0005509; GO:0005634; GO:0006355; GO:0006351 "calcium ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011992; IPR018247; IPR015070; IPR002048; EF-hand calcium-binding domain-containing protein 6 (DJ-1-binding protein) (DJBP) Efcab6 Djbp Kiaa1672 Mus musculus (Mouse) TR27263_c1_g1_i1 Q38868 CDPK9_ARATH 5.00E-06 GO:0005524; GO:0005509; GO:0004683; GO:0005886; GO:0007165 ATP binding; calcium ion binding; calmodulin-dependent protein kinase activity; plasma membrane; signal transduction IPR011992; IPR018247; IPR002048; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium-dependent protein kinase 9 (EC 2.7.11.1) (Calmodulin-domain protein kinase CDPK isoform 9) CPK9 At3g20410 MQC12.23 Arabidopsis thaliana (Mouse-ear cress) TR27264_c2_g1_i1 Q09621 LACT2_CAEEL 2.00E-50 GO:0016021 integral to membrane IPR001466; IPR012338; Beta-lactamase domain-containing protein 2 lact-2 ZK945.1 Caenorhabditis elegans TR27266_c1_g1_i1 Q52KN7 CPE1B_XENLA 9.00E-151 GO:0003723; GO:0005737; GO:0006397; GO:0016020; GO:0046872; GO:0005815; GO:0000166; GO:0006417; GO:0030529; GO:0000922 RNA binding; cytoplasm; mRNA processing; membrane; metal ion binding; microtubule organizing center; nucleotide binding; regulation of translation; ribonucleoprotein complex; spindle pole IPR012677; IPR000504; Cytoplasmic polyadenylation element-binding protein 1-B (CPE-BP1-B) (CPE-binding protein 1-B) (CPEB-1-B) cpeb1-b Xenopus laevis (African clawed frog) TR27267_c0_g1_i1 Q6PB06 AGPD1_XENLA 4.00E-18 GO:0005737; GO:0047992 cytoplasm; hydroxylysine kinase activity IPR002575; IPR011009; Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC 2.7.1.81) hykk agphd1 Xenopus laevis (African clawed frog) TR27270_c0_g1_i1 P23471 PTPRZ_HUMAN 1.00E-13 GO:0007409; GO:0007417; GO:0005887; GO:0072534; GO:0008330; GO:0005578; GO:0005001 Q9UM73 axonogenesis; central nervous system development; integral to plasma membrane; perineuronal net; protein tyrosine/threonine phosphatase activity; proteinaceous extracellular matrix; transmembrane receptor protein tyrosine phosphatase activity IPR001148; IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2) PTPRZ1 HTPZP2 PTPRZ PTPRZ2 PTPZ Homo sapiens (Human) TR27274_c0_g1_i1 Q9NW81 AT5SL_HUMAN 1.00E-30 GO:0005739 mitochondrion IPR026303; ATP synthase subunit s-like protein ATP5SL Homo sapiens (Human) TR27277_c0_g2_i1 Q55E26 GXCB_DICDI 7.00E-07 GO:0005089; GO:0051764; GO:0051015; GO:0005938; GO:0006897; GO:0006887; GO:0035556; GO:0005770; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; actin crosslink formation; actin filament binding; cell cortex; endocytosis; exocytosis; intracellular signal transduction; late endosome; phospholipid binding; regulation of Rho protein signal transduction IPR001715; IPR000219; IPR001331; IPR011993; IPR001849; IPR003096; Rac guanine nucleotide exchange factor B gxcB Trix DDB_G0269424 Dictyostelium discoideum (Slime mold) TR27277_c0_g3_i1 Q24799 MYPH_ECHGR 2.00E-42 IPR000557; IPR001715; IPR003096; Myophilin Echinococcus granulosus TR27285_c0_g1_i1 P02637 SCP_MIZYE 1.00E-23 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Sarcoplasmic calcium-binding protein (SCP) Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) TR27289_c0_g1_i1 A2RUH7 MBPHL_HUMAN 1.00E-10 IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Myosin-binding protein H-like MYBPHL Homo sapiens (Human) TR27289_c1_g1_i1 Q8WZ42 TITIN_HUMAN 7.00E-28 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR27289_c1_g1_i2 Q8WZ42 TITIN_HUMAN 1.00E-30 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR27289_c1_g1_i3 P11799 MYLK_CHICK 2.00E-09 GO:0005524; GO:0005829; GO:0016020; GO:0046872; GO:0004687 ATP binding; cytosol; membrane; metal ion binding; myosin light chain kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR020675; IPR000719; IPR017441; IPR002290; IPR008271; "Myosin light chain kinase, smooth muscle (MLCK) (EC 2.7.11.18) (Telokin)" Gallus gallus (Chicken) TR27289_c1_g2_i1 O97394 SDK_DROME 3.00E-11 GO:0007155; GO:0042675; GO:0005887; GO:0046533; GO:0050931 cell adhesion; compound eye cone cell differentiation; integral to plasma membrane; negative regulation of photoreceptor cell differentiation; pigment cell differentiation IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Protein sidekick sdk CG5227 Drosophila melanogaster (Fruit fly) TR27289_c1_g2_i2 Q86VF2 IGFN1_HUMAN 2.00E-19 GO:0030018; GO:0005634 Z disc; nucleus IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Immunoglobulin-like and fibronectin type III domain-containing protein 1 (EEF1A2-binding protein 1) (KY-interacting protein 1) IGFN1 EEF1A2BP1 KYIP1 Homo sapiens (Human) TR27292_c0_g1_i1 Q9D0T2 DUS12_MOUSE 4.00E-59 GO:0005737; GO:0046872; GO:0005634; GO:0035335; GO:0033133; GO:0004725; GO:0008138 cytoplasm; metal ion binding; nucleus; peptidyl-tyrosine dephosphorylation; positive regulation of glucokinase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR020422; IPR024950; IPR016278; IPR000387; Dual specificity protein phosphatase 12 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase T-DSP4) (Dual specificity phosphatase VH1) Dusp12 Mus musculus (Mouse) TR27294_c0_g1_i3 Q5VTT2 CI135_HUMAN 8.00E-41 GO:0016021 integral to membrane IPR027905; Uncharacterized protein C9orf135 C9orf135 Homo sapiens (Human) TR27297_c3_g1_i1 Q07646 MEST_MOUSE 2.00E-96 GO:0005783; GO:0005789; GO:0016787; GO:0016021; GO:0008152; GO:0010883; GO:0032526 endoplasmic reticulum; endoplasmic reticulum membrane; hydrolase activity; integral to membrane; metabolic process; regulation of lipid storage; response to retinoic acid IPR000639; Mesoderm-specific transcript protein (EC 3.-.-.-) (Paternally-expressed gene 1 protein) Mest Peg1 121a Mus musculus (Mouse) TR27297_c3_g1_i2 P53750 YN93_YEAST 1.00E-07 GO:0004091; GO:0004301; GO:0009636 carboxylesterase activity; epoxide hydrolase activity; response to toxic substance IPR000073; Uncharacterized hydrolase YNR064C (EC 3.1.-.-) YNR064C N3535 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR27305_c0_g1_i1 Q8BTK5 SMYD4_MOUSE 1.00E-21 GO:0046872; GO:0008168 metal ion binding; methyltransferase activity IPR001214; IPR011990; IPR002893; SET and MYND domain-containing protein 4 (EC 2.1.1.-) Smyd4 Kiaa1936 Mus musculus (Mouse) TR27307_c2_g1_i1 Q7L9B9 EEPD1_HUMAN 3.00E-43 GO:0003677; GO:0006281 DNA binding; DNA repair IPR004509; IPR005135; IPR003583; IPR010994; Endonuclease/exonuclease/phosphatase family domain-containing protein 1 EEPD1 KIAA1706 Homo sapiens (Human) TR27308_c0_g1_i1 Q8C206 GP157_MOUSE 5.00E-18 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR022343; IPR017981; IPR000832; IPR017452; Probable G-protein coupled receptor 157 Gpr157 Mus musculus (Mouse) TR27309_c0_g1_i1 Q9H2G9 GO45_HUMAN 4.00E-39 GO:0003677; GO:0005796; GO:0000139; GO:0007030; GO:0043001; GO:0008283; GO:0000278; GO:0005634; GO:0001558; GO:0006357; GO:0003700 DNA binding; Golgi lumen; Golgi membrane; Golgi organization; Golgi to plasma membrane protein transport; cell proliferation; mitotic cell cycle; nucleus; regulation of cell growth; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity IPR027095; IPR013183; Golgin-45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor) BLZF1 JEM1 Homo sapiens (Human) TR27310_c2_g1_i1 Q76CA2 ACTP2_CYMEC 2.00E-28 GO:0019835; GO:0044179; GO:0016021; GO:0006811; GO:0044218 cytolysis; hemolysis in other organism; integral to membrane; ion transport; other organism cell membrane IPR015926; Echotoxin-2 (Echt 2) Cymatium echo (Giant triton) (Monoplex echo) TR27312_c3_g1_i1 P13944 COCA1_CHICK 1.00E-13 GO:0007155; GO:0005581 cell adhesion; collagen IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain (Fibrochimerin) COL12A1 Gallus gallus (Chicken) TR27312_c3_g1_i2 Q6DCQ6 VWA2_XENLA 5.00E-10 GO:0005576 extracellular region IPR000742; IPR013032; IPR002035; von Willebrand factor A domain-containing protein 2 (A domain-containing protein similar to matrilin and collagen) (AMACO) vwa2 Xenopus laevis (African clawed frog) TR27315_c1_g1_i1 O89033 CDC6_MOUSE 1.00E-23 GO:0005524; GO:0006260; GO:0051301; GO:0003682; GO:0005737; GO:0007067; GO:0017111; GO:0005634; GO:0051984; GO:0032467; GO:0030071; GO:0005819; GO:0051233; GO:0000922 ATP binding; DNA replication; cell division; chromatin binding; cytoplasm; mitosis; nucleoside-triphosphatase activity; nucleus; positive regulation of chromosome segregation; positive regulation of cytokinesis; regulation of mitotic metaphase/anaphase transition; spindle; spindle midzone; spindle pole IPR003593; IPR015163; IPR016314; IPR027417; IPR011991; Cell division control protein 6 homolog (CDC6-related protein) (p62(cdc6)) Cdc6 Mus musculus (Mouse) TR27315_c6_g1_i1 P54789 ORC1_SCHPO 4.00E-09 GO:0005524; GO:0016887; GO:0006270; GO:0003688; GO:0031261; GO:0033314; GO:0000790; GO:0005664; GO:0005656; GO:0043596 ATP binding; ATPase activity; DNA replication initiation; DNA replication origin binding; DNA replication preinitiation complex; mitotic DNA replication checkpoint; nuclear chromatin; nuclear origin of replication recognition complex; nuclear pre-replicative complex; nuclear replication fork IPR003593; IPR017956; IPR003959; IPR001025; IPR020793; IPR027417; Origin recognition complex subunit 1 orc1 orp1 SPBC29A10.15 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR27318_c0_g2_i1 Q9D0N7 CAF1B_MOUSE 3.00E-112 GO:0033186; GO:0006281; GO:0006260; GO:0007049; GO:0031497; GO:0005829; GO:0005654; GO:0006355; GO:0006351 "CAF-1 complex; DNA repair; DNA replication; cell cycle; chromatin assembly; cytosol; nucleoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001632; IPR015943; IPR001680; IPR019775; IPR017986; Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) Chaf1b Mus musculus (Mouse) TR27321_c1_g1_i1 O35551 RABE1_MOUSE 4.00E-46 GO:0005096; GO:0006915; GO:0005769; GO:0030139; GO:0006897; GO:0005768; GO:0043547; GO:0015031; GO:0055037 GTPase activator activity; apoptotic process; early endosome; endocytic vesicle; endocytosis; endosome; positive regulation of GTPase activity; protein transport; recycling endosome IPR003914; IPR018514; IPR015390; Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) Rabep1 Rab5ep Rabpt5 Rabpt5a Mus musculus (Mouse) TR27326_c3_g1_i1 Q32NR9 FRITZ_XENLA 7.00E-113 GO:0035085; GO:0060271; GO:0005856; GO:0060031; GO:0005886; GO:0016476; GO:0032880; GO:0032185 cilium axoneme; cilium morphogenesis; cytoskeleton; mediolateral intercalation; plasma membrane; regulation of embryonic cell shape; regulation of protein localization; septin cytoskeleton organization IPR024511; IPR015943; IPR017986; WD repeat-containing and planar cell polarity effector protein fritz homolog (WD repeat-containing and planar cell polarity effector protein) wdpcp fritz Xenopus laevis (African clawed frog) TR27329_c0_g1_i1 P28075 PSB5_RAT 2.00E-115 GO:0005737; GO:0005634; GO:0005839; GO:0051603; GO:0004298 cytoplasm; nucleus; proteasome core complex; proteolysis involved in cellular protein catabolic process; threonine-type endopeptidase activity IPR000243; IPR016050; IPR001353; IPR023333; Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit X) Psmb5 Rattus norvegicus (Rat) TR27329_c0_g1_i2 P28063 PSB8_MOUSE 2.00E-15 GO:0019882; GO:0005829; GO:0045444; GO:0005634; GO:0005839; GO:0051603; GO:1990111; GO:0004298 antigen processing and presentation; cytosol; fat cell differentiation; nucleus; proteasome core complex; proteolysis involved in cellular protein catabolic process; spermatoproteasome complex; threonine-type endopeptidase activity IPR000243; IPR016050; IPR001353; IPR023333; Proteasome subunit beta type-8 (EC 3.4.25.1) (Low molecular mass protein 7) (Macropain subunit C13) (Multicatalytic endopeptidase complex subunit C13) (Proteasome component C13) (Proteasome subunit beta-5i) Psmb8 Lmp7 Mc13 Mus musculus (Mouse) TR27331_c0_g1_i1 Q80ZN9 CX6B2_MOUSE 2.00E-09 GO:0004129; GO:0030061 cytochrome-c oxidase activity; mitochondrial crista IPR003213; "Cytochrome c oxidase subunit 6B2 (Cytochrome c oxidase subunit VIb isoform 2) (COX VIb-2) (Cytochrome c oxidase subunit VIb, testis-specific isoform)" Cox6b2 Mus musculus (Mouse) TR27331_c0_g1_i2 Q01519 COX12_YEAST 6.00E-12 GO:0004129; GO:0005758; GO:0005751; GO:0033617 cytochrome-c oxidase activity; mitochondrial intermembrane space; mitochondrial respiratory chain complex IV; mitochondrial respiratory chain complex IV assembly IPR003213; Cytochrome c oxidase subunit 6B (Cytochrome c oxidase polypeptide VIb) COX12 YLR038C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR27333_c0_g1_i1 Q5F3L3 K1467_CHICK 4.00E-09 GO:0016021 integral to membrane IPR027295; IPR011047; Uncharacterized protein KIAA1467 homolog RCJMB04_14d19 Gallus gallus (Chicken) TR27333_c0_g1_i2 Q5M7W6 ITFG3_RAT 6.00E-06 GO:0016021 integral to membrane IPR011047; Protein ITFG3 Itfg3 Rattus norvegicus (Rat) TR27334_c0_g1_i1 B3RFR8 HYDMA_HYDVU 9.00E-19 GO:0042742; GO:0045087; GO:0016020; GO:0044218 defense response to bacterium; innate immune response; membrane; other organism cell membrane Hydramacin-1 (Hm-1) Hydra vulgaris (Hydra) (Hydra attenuata) TR27336_c0_g1_i2 P30051 TEAD1_MOUSE 0 GO:0003677; GO:0003143; GO:0035329; GO:0048368; GO:0030903; GO:0005634; GO:0048339; GO:0045944; GO:0042127; GO:0003700; GO:0005667; GO:0006351 "DNA binding; embryonic heart tube morphogenesis; hippo signaling cascade; lateral mesoderm development; notochord development; nucleus; paraxial mesoderm development; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent" IPR000818; IPR016361; Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) Tead1 Tcf13 Tef-1 Tef1 Mus musculus (Mouse) TR27336_c0_g1_i3 P48984 TEAD4_CHICK 0 GO:0003677; GO:0035329; GO:0005634; GO:0003700; GO:0006351 "DNA binding; hippo signaling cascade; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000818; IPR016361; IPR027255; Transcriptional enhancer factor TEF-3 (M-CAT-binding factor) (RTEF-1) (TEA domain family member 4) (TEAD-4) (TEF-1) TEAD4 TEF-1 TEF3 Gallus gallus (Chicken) TR27336_c0_g1_i5 P48984 TEAD4_CHICK 0 GO:0003677; GO:0035329; GO:0005634; GO:0003700; GO:0006351 "DNA binding; hippo signaling cascade; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000818; IPR016361; IPR027255; Transcriptional enhancer factor TEF-3 (M-CAT-binding factor) (RTEF-1) (TEA domain family member 4) (TEAD-4) (TEF-1) TEAD4 TEF-1 TEF3 Gallus gallus (Chicken) TR27336_c0_g1_i6 Q19849 EGL44_CAEEL 1.00E-36 GO:0003677; GO:0035329; GO:0030182; GO:0005634; GO:0045944; GO:0000981 DNA binding; hippo signaling cascade; neuron differentiation; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR000818; IPR016361; Transcription enhancer factor-like protein egl-44 (Egg-laying defective protein 44) egl-44 F28B12.2 Caenorhabditis elegans TR27336_c0_g1_i9 P30051 TEAD1_MOUSE 0 GO:0003677; GO:0003143; GO:0035329; GO:0048368; GO:0030903; GO:0005634; GO:0048339; GO:0045944; GO:0042127; GO:0003700; GO:0005667; GO:0006351 "DNA binding; embryonic heart tube morphogenesis; hippo signaling cascade; lateral mesoderm development; notochord development; nucleus; paraxial mesoderm development; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent" IPR000818; IPR016361; Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) Tead1 Tcf13 Tef-1 Tef1 Mus musculus (Mouse) TR27337_c0_g2_i1 P49356 FNTB_HUMAN 7.00E-136 GO:0005829; GO:0004311; GO:0046872; GO:0005875; GO:0008285; GO:0045787; GO:0048146; GO:0051770; GO:0018343; GO:0004660; GO:0005965; GO:0022400; GO:0034097; GO:0010035; GO:0014070; GO:0016056; GO:0042060 P49354 cytosol; farnesyltranstransferase activity; metal ion binding; microtubule associated complex; negative regulation of cell proliferation; positive regulation of cell cycle; positive regulation of fibroblast proliferation; positive regulation of nitric-oxide synthase biosynthetic process; protein farnesylation; protein farnesyltransferase activity; protein farnesyltransferase complex; regulation of rhodopsin mediated signaling pathway; response to cytokine stimulus; response to inorganic substance; response to organic cyclic compound; rhodopsin mediated signaling pathway; wound healing IPR026872; IPR001330; IPR008930; Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) FNTB Homo sapiens (Human) TR27339_c0_g1_i1 Q61493 DPOLZ_MOUSE 7.00E-155 GO:0051539; GO:0003677; GO:0006260; GO:0003887; GO:0005694; GO:0046872; GO:0000166; GO:0005634; GO:0019985; GO:0016035 "4 iron, 4 sulfur cluster binding; DNA binding; DNA replication; DNA-directed DNA polymerase activity; chromosome; metal ion binding; nucleotide binding; nucleus; translesion synthesis; zeta DNA polymerase complex" IPR006172; IPR017964; IPR006133; IPR006134; IPR023211; IPR012337; IPR025687; DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (Seizure-related protein 4) Rev3l Polz Sez4 Mus musculus (Mouse) TR27339_c2_g1_i1 O60673 DPOLZ_HUMAN 2.00E-56 GO:0051539; GO:0003677; GO:0006261; GO:0003887; GO:0005694; GO:0046872; GO:0000166; GO:0005634; GO:0019985; GO:0016035 Q9UI95 "4 iron, 4 sulfur cluster binding; DNA binding; DNA-dependent DNA replication; DNA-directed DNA polymerase activity; chromosome; metal ion binding; nucleotide binding; nucleus; translesion synthesis; zeta DNA polymerase complex" IPR006172; IPR017964; IPR006133; IPR006134; IPR023211; IPR012337; IPR025687; DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) REV3L POLZ REV3 Homo sapiens (Human) TR27341_c6_g1_i1 A9CPT4 TDRD1_ORYLA 5.00E-07 GO:0043046; GO:0031047; GO:0007281; GO:0007126; GO:0046872; GO:0007275; GO:0071546; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; gene silencing by RNA; germ cell development; meiosis; metal ion binding; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002999; IPR002893; Tudor domain-containing protein 1 tdrd1 Oryzias latipes (Medaka fish) (Japanese ricefish) TR27341_c8_g1_i1 Q58EK5 TDRD1_DANRE 7.00E-13 GO:0043046; GO:0031047; GO:0007281; GO:0007126; GO:0046872; GO:0007275; GO:0071546; GO:0034587; GO:0007283 Q8UVX0; A2CEI6 DNA methylation involved in gamete generation; gene silencing by RNA; germ cell development; meiosis; metal ion binding; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002999; IPR002893; Tudor domain-containing protein 1 tdrd1 im:7155161 Danio rerio (Zebrafish) (Brachydanio rerio) TR27342_c2_g1_i1 Q9GZZ6 ACH10_HUMAN 3.00E-43 GO:0004889; GO:0030424; GO:0005262; GO:0030054; GO:0050910; GO:0007204; GO:0042472; GO:0016021; GO:0016020; GO:0043204; GO:0045211; GO:0005102; GO:0042127; GO:0007271 "acetylcholine-activated cation-selective channel activity; axon; calcium channel activity; cell junction; detection of mechanical stimulus involved in sensory perception of sound; elevation of cytosolic calcium ion concentration; inner ear morphogenesis; integral to membrane; membrane; perikaryon; postsynaptic membrane; receptor binding; regulation of cell proliferation; synaptic transmission, cholinergic" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 NACHRA10 Homo sapiens (Human) TR27345_c1_g1_i1 Q6DRC4 EIF3G_DANRE 2.00E-122 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0000166; GO:0006446; GO:0003743; GO:0006413 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; nucleotide binding; regulation of translational initiation; translation initiation factor activity; translational initiation IPR017334; IPR024675; IPR012677; IPR000504; Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) eif3g eif3s4 Danio rerio (Zebrafish) (Brachydanio rerio) TR27347_c0_g1_i1 P42317 YXJF_BACSU 2.00E-11 GO:0003858 3-hydroxybutyrate dehydrogenase activity IPR011294; IPR002198; IPR002347; IPR016040; IPR020904; Uncharacterized oxidoreductase YxjF (EC 1.-.-.-) yxjF BSU38970 N15M Bacillus subtilis (strain 168) TR27347_c2_g1_i2 Q9X6U2 BDHA_CUPNH 1.00E-48 GO:0003858 3-hydroxybutyrate dehydrogenase activity IPR011294; IPR002198; IPR002347; IPR016040; IPR020904; D-beta-hydroxybutyrate dehydrogenase (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (3-HBDH) hbdH1 H16_A1334 Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) TR27347_c2_g1_i3 O42866 FABG_SCHPO 1.00E-11 GO:0004316; GO:0009060; GO:0009107; GO:0005739 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; aerobic respiration; lipoate biosynthetic process; mitochondrion IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) oar2 SPAC3G9.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR27351_c2_g1_i1 Q61329 ZFHX3_MOUSE 5.00E-38 GO:0005739; GO:0007517; GO:0005634; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "mitochondrion; muscle organ development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR017970; IPR001356; IPR009057; IPR007087; IPR015880; IPR013087; IPR003604; Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) Zfhx3 Atbf1 Mus musculus (Mouse) TR27352_c0_g1_i1 Q91ZT9 ASB8_MOUSE 3.00E-75 GO:0005737; GO:0035556; GO:0016567 cytoplasm; intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 8 (ASB-8) Asb8 Mus musculus (Mouse) TR27352_c0_g1_i2 Q502K3 ANR52_DANRE 5.00E-22 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) TR27352_c0_g1_i3 Q91ZT9 ASB8_MOUSE 2.00E-74 GO:0005737; GO:0035556; GO:0016567 cytoplasm; intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 8 (ASB-8) Asb8 Mus musculus (Mouse) TR27353_c4_g1_i1 Q5RDU4 PARP6_PONAB 1.00E-119 GO:0003950 NAD+ ADP-ribosyltransferase activity IPR012317; Poly [ADP-ribose] polymerase 6 (PARP-6) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 17) (ARTD17) PARP6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR27354_c0_g1_i1 Q54CH1 ADCA_DICDI 2.00E-08 GO:0016021; GO:0044354; GO:0046872; GO:0045335; GO:0007165 integral to membrane; macropinosome; metal ion binding; phagocytic vesicle; signal transduction IPR011021; IPR014752; IPR011022; IPR014756; IPR000306; IPR017455; IPR011011; IPR013083; Arrestin domain-containing protein A adcA DDB_G0292924 Dictyostelium discoideum (Slime mold) TR27359_c5_g2_i1 Q86T24 KAISO_HUMAN 9.00E-06 GO:0003677; GO:0016055; GO:0005737; GO:0035556; GO:0046872; GO:0005730; GO:0005886; GO:0006355; GO:0006351 "DNA binding; Wnt receptor signaling pathway; cytoplasm; intracellular signal transduction; metal ion binding; nucleolus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33) ZBTB33 KAISO ZNF348 Homo sapiens (Human) TR27359_c5_g2_i3 Q8CE33 KLH11_MOUSE 1.00E-08 IPR011705; IPR000210; IPR011333; IPR013069; IPR015915; IPR006652; Kelch-like protein 11 Klhl11 Mus musculus (Mouse) TR27359_c5_g2_i4 Q8K2J9 BTBD6_MOUSE 2.00E-26 GO:0000932 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6 Btbd6 Mus musculus (Mouse) TR27363_c0_g1_i1 Q29RU2 OIT3_BOVIN 1.00E-16 GO:0005509; GO:0005635 calcium ion binding; nuclear envelope IPR000742; IPR000152; IPR018097; IPR009030; IPR001507; Oncoprotein-induced transcript 3 protein OIT3 Bos taurus (Bovine) TR27363_c0_g1_i2 Q29RU2 OIT3_BOVIN 3.00E-16 GO:0005509; GO:0005635 calcium ion binding; nuclear envelope IPR000742; IPR000152; IPR018097; IPR009030; IPR001507; Oncoprotein-induced transcript 3 protein OIT3 Bos taurus (Bovine) TR27366_c0_g1_i2 Q8K0U4 HS12A_MOUSE 5.00E-72 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR27366_c0_g1_i3 Q8K0U4 HS12A_MOUSE 9.00E-72 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR27367_c0_g1_i1 P50462 CSRP3_MOUSE 6.00E-14 GO:0030018; GO:0042805; GO:0060048; GO:0003300; GO:0055003; GO:0006874; GO:0005856; GO:0035995; GO:0007517; GO:0005634; GO:0033365; GO:0002026; GO:0008307; GO:0008270 Z disc; actinin binding; cardiac muscle contraction; cardiac muscle hypertrophy; cardiac myofibril assembly; cellular calcium ion homeostasis; cytoskeleton; detection of muscle stretch; muscle organ development; nucleus; protein localization to organelle; regulation of the force of heart contraction; structural constituent of muscle; zinc ion binding IPR001781; "Cysteine and glycine-rich protein 3 (Cysteine-rich protein 3) (CRP3) (LIM domain protein, cardiac) (Muscle LIM protein)" Csrp3 Clp Mlp Mus musculus (Mouse) TR27372_c1_g1_i1 Q9JJX8 ST32B_MOUSE 2.00E-117 GO:0005524; GO:0046872; GO:0004674 ATP binding; metal ion binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase 32B (EC 2.7.11.1) Stk32b Stk32 Mus musculus (Mouse) TR27373_c0_g1_i1 Q9DEY9 BLM_XENLA 5.00E-24 GO:0005524; GO:0043140; GO:0004003; GO:0003677; GO:0000729; GO:0006310; GO:0006260; GO:0005634 ATP binding; ATP-dependent 3'-5' DNA helicase activity; ATP-dependent DNA helicase activity; DNA binding; DNA double-strand break processing; DNA recombination; DNA replication; nucleus IPR012532; IPR011545; IPR002464; IPR004589; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR018982; IPR011991; Bloom syndrome protein homolog (xBLM) (EC 3.6.4.12) (RecQ helicase homolog) blm Xenopus laevis (African clawed frog) TR27373_c0_g2_i1 P54132 BLM_HUMAN 1.00E-20 GO:0005524; GO:0043140; GO:0004003; GO:0000729; GO:0051880; GO:0031572; GO:0016605; GO:0046632; GO:0036310; GO:0000405; GO:0072757; GO:0072711; GO:0071479; GO:0005737; GO:0000724; GO:0009378; GO:0000800; GO:0001673; GO:0000085; GO:0045910; GO:0051782; GO:0045950; GO:0016363; GO:0005730; GO:0046641; GO:0045893; GO:0045120; GO:0051259; GO:0051098; GO:0000079; GO:0005657; GO:0031297; GO:0048478; GO:0010165; GO:0003697; GO:0000723 Q9BX63; P39748; Q9H9A7; P27694; P54274; Q15554; Q14191 "ATP binding; ATP-dependent 3'-5' DNA helicase activity; ATP-dependent DNA helicase activity; DNA double-strand break processing; G-quadruplex DNA binding; G2 DNA damage checkpoint; PML body; alpha-beta T cell differentiation; annealing helicase activity; bubble DNA binding; cellular response to camptothecin; cellular response to hydroxyurea; cellular response to ionizing radiation; cytoplasm; double-strand break repair via homologous recombination; four-way junction helicase activity; lateral element; male germ cell nucleus; mitotic G2 phase; negative regulation of DNA recombination; negative regulation of cell division; negative regulation of mitotic recombination; nuclear matrix; nucleolus; positive regulation of alpha-beta T cell proliferation; positive regulation of transcription, DNA-dependent; pronucleus; protein oligomerization; regulation of binding; regulation of cyclin-dependent protein serine/threonine kinase activity; replication fork; replication fork processing; replication fork protection; response to X-ray; single-stranded DNA binding; telomere maintenance" IPR012532; IPR011545; IPR002464; IPR004589; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR018982; IPR011991; "Bloom syndrome protein (EC 3.6.4.12) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3)" BLM RECQ2 RECQL3 Homo sapiens (Human) TR27374_c0_g1_i4 P56819 BACE1_RAT 5.00E-135 GO:0005794; GO:0004190; GO:0030424; GO:0050435; GO:0009986; GO:0030659; GO:0005783; GO:0005768; GO:0005887; GO:0006508; GO:0005802 Golgi apparatus; aspartic-type endopeptidase activity; axon; beta-amyloid metabolic process; cell surface; cytoplasmic vesicle membrane; endoplasmic reticulum; endosome; integral to plasma membrane; proteolysis; trans-Golgi network IPR001461; IPR001969; IPR009119; IPR009120; IPR021109; Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2) Bace1 Bace Rattus norvegicus (Rat) TR27375_c2_g1_i2 Q66H10 FBX39_RAT 6.00E-18 IPR001810; F-box only protein 39 Fbxo39 Rattus norvegicus (Rat) TR27379_c0_g1_i1 P83425 HIP_MYTED 7.00E-07 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR2738_c0_g1_i1 Q54F46 WARA_DICDI 2.00E-06 GO:0009653; GO:0007275; GO:0005634; GO:0045595; GO:0043565; GO:0003700; GO:0006351 "anatomical structure morphogenesis; multicellular organismal development; nucleus; regulation of cell differentiation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR002110; IPR020683; IPR017970; IPR001356; IPR009057; Homeobox protein Wariai (Homeobox protein 1) (DdHbx-1) warA hbx1 wri DDB_G0291075 Dictyostelium discoideum (Slime mold) TR27380_c1_g1_i1 P29373 RABP2_HUMAN 9.00E-11 GO:0005737; GO:0035115; GO:0005783; GO:0008544; GO:0005634; GO:0006355; GO:0016918; GO:0001972; GO:0042573; GO:0005501; GO:0019841; GO:0007165; GO:0005215 "cytoplasm; embryonic forelimb morphogenesis; endoplasmic reticulum; epidermis development; nucleus; regulation of transcription, DNA-dependent; retinal binding; retinoic acid binding; retinoic acid metabolic process; retinoid binding; retinol binding; signal transduction; transporter activity" IPR012674; IPR011038; IPR000463; IPR000566; Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II) CRABP2 Homo sapiens (Human) TR27380_c1_g1_i3 Q5PXY7 RABP2_BOVIN 5.00E-19 GO:0005737; GO:0005783; GO:0005634; GO:0016918; GO:0019841; GO:0005215 cytoplasm; endoplasmic reticulum; nucleus; retinal binding; retinol binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II) CRABP2 Bos taurus (Bovine) TR27381_c3_g1_i1 Q8WN96 ITPR2_BOVIN 1.00E-12 GO:0005789; GO:0005220; GO:0048016; GO:0016021; GO:0030658 "endoplasmic reticulum membrane; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; inositol phosphate-mediated signaling; integral to membrane; transport vesicle membrane" IPR016024; IPR000699; IPR014821; IPR000493; IPR005821; IPR016093; IPR013662; IPR015925; "Inositol 1,4,5-trisphosphate receptor type 2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor)" ITPR2 Bos taurus (Bovine) TR27383_c1_g1_i1 Q9NUV9 GIMA4_HUMAN 2.00E-33 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR27383_c1_g1_i2 Q99JY3 GIMA4_MOUSE 4.00E-26 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Mus musculus (Mouse) TR27384_c0_g1_i2 O43529 CHSTA_HUMAN 3.00E-07 GO:0005794; GO:0000139; GO:0016232; GO:0016051; GO:0007155; GO:0016021; GO:0007612; GO:0007616; GO:0016020; GO:0008146 Golgi apparatus; Golgi membrane; HNK-1 sulfotransferase activity; carbohydrate biosynthetic process; cell adhesion; integral to membrane; learning; long-term memory; membrane; sulfotransferase activity IPR018011; IPR005331; Carbohydrate sulfotransferase 10 (EC 2.8.2.-) (HNK-1 sulfotransferase) (HNK-1ST) (HNK1ST) (HuHNK-1ST) CHST10 Homo sapiens (Human) TR27387_c0_g1_i1 O08740 RPB11_MOUSE 2.00E-62 GO:0003677; GO:0005665; GO:0003899; GO:0006351 "DNA binding; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase activity; transcription, DNA-dependent" IPR009025; IPR008193; DNA-directed RNA polymerase II subunit RPB11 (RNA polymerase II subunit B11) (DNA-directed RNA polymerase II subunit J) (RNA polymerase II 13.3 kDa subunit) (RPB14) Polr2j Rpo2-4 Mus musculus (Mouse) TR27391_c0_g1_i1 Q3SZE9 TBCC_BOVIN 2.00E-80 GO:0003924; GO:0000902; GO:0005829; GO:0032391; GO:0007023 GTPase activity; cell morphogenesis; cytosol; photoreceptor connecting cilium; post-chaperonin tubulin folding pathway IPR017901; IPR016098; IPR006599; IPR027684; IPR012945; Tubulin-specific chaperone C (Tubulin-folding cofactor C) (CFC) TBCC Bos taurus (Bovine) TR27401_c0_g2_i2 O61492 FLOT2_DROME 1.00E-07 GO:0007155; GO:0016600; GO:0035011; GO:0005198 cell adhesion; flotillin complex; melanotic encapsulation of foreign target; structural molecule activity IPR001107; IPR027705; Flotillin-2 Flo-2 FLODm-2 CG32593 Drosophila melanogaster (Fruit fly) TR27407_c0_g2_i1 D3ZUK3 DLK2_RAT 9.00E-08 GO:0005509; GO:0016021; GO:0045746; GO:0045598 calcium ion binding; integral to membrane; negative regulation of Notch signaling pathway; regulation of fat cell differentiation IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; Protein delta homolog 2 (DLK-2) (Endothelial cell-specific protein S-1) (Epidermal growth factor-like protein 9) (EGF-like protein 9) Dlk2 Egfl9 Rattus norvegicus (Rat) TR27407_c0_g2_i2 Q5T1H1 EYS_HUMAN 2.00E-07 GO:0005509; GO:0005576; GO:0050896; GO:0007601 calcium ion binding; extracellular region; response to stimulus; visual perception IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protein eyes shut homolog (Epidermal growth factor-like protein 10) (EGF-like protein 10) (Epidermal growth factor-like protein 11) (EGF-like protein 11) (Protein spacemaker homolog) EYS C6orf178 C6orf179 C6orf180 EGFL10 EGFL11 SPAM UNQ9424/PRO34591 Homo sapiens (Human) TR27409_c0_g2_i1 Q12955 ANK3_HUMAN 2.00E-69 GO:0043001; GO:0030315; GO:0007411; GO:0043194; GO:0007409; GO:0016323; GO:0045296; GO:0009986; GO:0043034; GO:0014704; GO:0044325; GO:0016328; GO:0005764; GO:0072660; GO:0071709; GO:0000281; GO:0033268; GO:0033270; GO:0010628; GO:1900827; GO:0045838; GO:2000651; GO:0010765; GO:0045211; GO:0030674; GO:0072661; GO:0019228; GO:0043266; GO:0007165; GO:0030507; GO:0014731; GO:0005200; GO:0050808 "Golgi to plasma membrane protein transport; T-tubule; axon guidance; axon initial segment; axonogenesis; basolateral plasma membrane; cadherin binding; cell surface; costamere; intercalated disc; ion channel binding; lateral plasma membrane; lysosome; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; node of Ranvier; paranode region of axon; positive regulation of gene expression; positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; postsynaptic membrane; protein binding, bridging; protein targeting to plasma membrane; regulation of action potential in neuron; regulation of potassium ion transport; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton; synapse organization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) TR27413_c0_g1_i1 Q8AWD2 MOCS3_DANRE 2.00E-143 GO:0005524; GO:0006777; GO:0042292; GO:0005829; GO:0018192; GO:0046872; GO:0016779; GO:0034227; GO:0002098; GO:0004792 ATP binding; Mo-molybdopterin cofactor biosynthetic process; URM1 activating enzyme activity; cytosol; enzyme active site formation via L-cysteine persulfide; metal ion binding; nucleotidyltransferase activity; tRNA thio-modification; tRNA wobble uridine modification; thiosulfate sulfurtransferase activity IPR007901; IPR009036; IPR016040; IPR001763; IPR000594; tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. Cofactor biosynthesis; molybdopterin biosynthesis. Adenylyltransferase and sulfurtransferase MOCS3 (Molybdenum cofactor synthesis protein 3) [Includes: Molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) (Adenylyltransferase MOCS3) (Sulfur carrier protein MOCS2A adenylyltransferase); Molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) (Sulfur carrier protein MOCS2A sulfurtransferase) (Sulfurtransferase MOCS3)] mocs3 uba4 zgc:55696 Danio rerio (Zebrafish) (Brachydanio rerio) TR27413_c0_g1_i3 P20973 UBE11_WHEAT 2.00E-12 GO:0005524; GO:0016874; GO:0016567; GO:0008641 ATP binding; ligase activity; protein ubiquitination; small protein activating enzyme activity IPR009036; IPR016040; IPR000594; IPR018965; IPR023280; IPR000127; IPR019572; IPR018075; IPR018074; IPR000011; Protein modification; protein ubiquitination. Ubiquitin-activating enzyme E1 1 UBA1 Triticum aestivum (Wheat) TR27419_c0_g1_i1 Q8BMT9 HHAT_MOUSE 9.00E-51 GO:0005525; GO:0005789; GO:0016021; GO:0007275; GO:0016409; GO:0018345; GO:0007224 GTP binding; endoplasmic reticulum membrane; integral to membrane; multicellular organismal development; palmitoyltransferase activity; protein palmitoylation; smoothened signaling pathway IPR004299; Protein-cysteine N-palmitoyltransferase HHAT (EC 2.3.1.-) (Hedgehog acyltransferase) (Skinny hedgehog protein) Hhat Skn Mus musculus (Mouse) TR2742_c0_g1_i1 P58353 GTR5_BOVIN 2.00E-07 GO:0016324; GO:0071332; GO:0005353; GO:0016021 apical plasma membrane; cellular response to fructose stimulus; fructose transmembrane transporter activity; integral to membrane IPR002442; IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5)" SLC2A5 GLUT5 Bos taurus (Bovine) TR27421_c2_g2_i1 Q9BXW9 FACD2_HUMAN 7.00E-60 GO:0006281; GO:0000793; GO:0007276; GO:0005654; GO:0010332; GO:0007129 P51587; Q9NVI1; Q16658; O00255; P49959; O60934 DNA repair; condensed chromosome; gamete generation; nucleoplasm; response to gamma radiation; synapsis Fanconi anemia group D2 protein (Protein FACD2) FANCD2 FACD Homo sapiens (Human) TR27423_c0_g1_i1 Q9VUL9 FUCTA_DROME 2.00E-37 GO:0033932; GO:0032580; GO:0005797; GO:0036071; GO:0018392; GO:0016021; GO:0007399; GO:0006486 Q9VG62 "1,3-alpha-L-fucosidase activity; Golgi cisterna membrane; Golgi medial cisterna; N-glycan fucosylation; glycoprotein 3-alpha-L-fucosyltransferase activity; integral to membrane; nervous system development; protein glycosylation" IPR001503; Protein modification; protein glycosylation. "Glycoprotein 3-alpha-L-fucosyltransferase A (EC 2.4.1.214) (Core alpha-(1,3)-fucosyltransferase)" FucTA CG6869 Drosophila melanogaster (Fruit fly) TR27427_c0_g1_i1 Q9D0A0 DET1_MOUSE 0 GO:0005634 nucleus IPR019138; DET1 homolog (De-etiolated-1 homolog) Det1 Mus musculus (Mouse) TR27432_c2_g1_i1 Q86WZ6 ZN227_HUMAN 2.00E-37 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 227 ZNF227 Homo sapiens (Human) TR27438_c3_g1_i1 Q9R0X4 ACOT9_MOUSE 8.00E-48 GO:0003986; GO:0047617; GO:0006637; GO:0004091; GO:0005739 acetyl-CoA hydrolase activity; acyl-CoA hydrolase activity; acyl-CoA metabolic process; carboxylesterase activity; mitochondrion "Acyl-coenzyme A thioesterase 9, mitochondrial (Acyl-CoA thioesterase 9) (EC 3.1.2.-) (Acyl coenzyme A thioester hydrolase 2) (MTE-2) (Acyl-CoA thioester hydrolase 9) (Mitochondrial 48 kDa acyl-CoA thioester hydrolase 1) (Mt-ACT48.1) (Protein U8) (p48)" Acot9 Acate2 Mus musculus (Mouse) TR27438_c3_g1_i2 Q3SWX2 ACOT9_BOVIN 1.00E-53 GO:0004091; GO:0005739 carboxylesterase activity; mitochondrion "Acyl-coenzyme A thioesterase 9, mitochondrial (Acyl-CoA thioesterase 9) (EC 3.1.2.-) (Acyl-CoA thioester hydrolase 9)" ACOT9 Bos taurus (Bovine) TR27439_c4_g2_i1 B1H2P5 CE120_XENTR 1.00E-51 GO:0005737; GO:0005815 cytoplasm; microtubule organizing center IPR000008; IPR022136; Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100) cep120 ccdc100 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR27439_c5_g1_i1 Q8N960 CE120_HUMAN 2.00E-74 GO:0030953; GO:0005813; GO:0021987; GO:0005737; GO:0022027; GO:0022008; GO:0032886; GO:0032880 astral microtubule organization; centrosome; cerebral cortex development; cytoplasm; interkinetic nuclear migration; neurogenesis; regulation of microtubule-based process; regulation of protein localization IPR000008; IPR022136; Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100) CEP120 CCDC100 Homo sapiens (Human) TR27440_c1_g1_i1 Q6EX42 PI5K1_ORYSJ 4.00E-10 GO:0016308; GO:0005524; GO:0030154; GO:0009908; GO:0046854 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding; cell differentiation; flower development; phosphatidylinositol phosphorylation IPR003409; IPR017163; IPR023610; IPR027483; IPR002498; IPR027484; IPR016034; Phosphatidylinositol 4-phosphate 5-kinase 1 (EC 2.7.1.68) (1-phosphatidylinositol 4-phosphate kinase) (Diphosphoinositide kinase) (PIP5K) (PtdIns(4)P-5-kinase) PIPK1 Os03g0701800 LOC_Os03g49510 Oryza sativa subsp. japonica (Rice) TR27440_c1_g1_i2 Q641X6 MORN1_RAT 3.00E-27 IPR003409; MORN repeat-containing protein 1 Morn1 Rattus norvegicus (Rat) TR27440_c3_g2_i1 Q5T089 MORN1_HUMAN 3.00E-10 IPR003409; MORN repeat-containing protein 1 MORN1 Homo sapiens (Human) TR27448_c0_g1_i2 A6NDJ8 RB43L_HUMAN 1.00E-06 GO:0005525; GO:0015031; GO:0007264 GTP binding; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Putative Rab-43-like protein ENSP00000330714 Homo sapiens (Human) TR27448_c0_g1_i3 A4IHM6 RABL3_XENTR 4.00E-80 GO:0005525; GO:0007264 GTP binding; small GTPase mediated signal transduction IPR027417; IPR001806; Rab-like protein 3 rabl3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR27448_c0_g1_i4 Q5HYI8 RABL3_HUMAN 4.00E-79 GO:0005525; GO:0007264 GTP binding; small GTPase mediated signal transduction IPR027417; IPR001806; Rab-like protein 3 RABL3 Homo sapiens (Human) TR27448_c0_g1_i6 Q5ZKR4 RABL3_CHICK 4.00E-80 GO:0005525; GO:0007264 GTP binding; small GTPase mediated signal transduction IPR027417; IPR025662; IPR001806; Rab-like protein 3 RABL3 RCJMB04_9j2 Gallus gallus (Chicken) TR27449_c0_g1_i2 Q9WV82 TLR4_CRIGR 3.00E-07 GO:0002755; GO:0050829; GO:0032497; GO:0006954; GO:0045087; GO:0001875; GO:0046696; GO:0042116; GO:0050707; GO:0034142; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-negative bacterium; detection of lipopolysaccharide; inflammatory response; innate immune response; lipopolysaccharide receptor activity; lipopolysaccharide receptor complex; macrophage activation; regulation of cytokine secretion; toll-like receptor 4 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR025875; IPR003591; IPR000157; IPR027168; IPR017241; Toll-like receptor 4 (CD antigen CD284) TLR4 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR27450_c2_g1_i1 O95786 DDX58_HUMAN 7.00E-17 GO:0005524; GO:0008026; GO:0039529; GO:0015629; GO:0005829; GO:0009597; GO:0003690; GO:0003725; GO:0045087; GO:0019048; GO:0032480; GO:0002230; GO:0032727; GO:0032728; GO:0051091; GO:0042993; GO:0045944; GO:0030334; GO:0034344; GO:0043330; GO:0032587; GO:0003727; GO:0005923; GO:0008270 Itself; P04543; Q920D5; Q9NQC7; O00571; Q7Z434; P21699; P04487; Q96S55; Q6IUF9; Q6IVU5; Q6UY62; Q6UY71; Q7Z2W4; Q7Z2W4-2 ATP binding; ATP-dependent helicase activity; RIG-I signaling pathway; actin cytoskeleton; cytosol; detection of virus; double-stranded DNA binding; double-stranded RNA binding; innate immune response; modulation by virus of host morphology or physiology; negative regulation of type I interferon production; positive regulation of defense response to virus by host; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of cell migration; regulation of type III interferon production; response to exogenous dsRNA; ruffle membrane; single-stranded RNA binding; tight junction; zinc ion binding IPR003593; IPR011029; IPR011545; IPR014001; IPR001650; IPR027417; IPR021673; Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) DDX58 Homo sapiens (Human) TR27452_c0_g1_i1 P57093 PAHX_RAT 4.00E-116 GO:0031418; GO:0048037; GO:0001561; GO:0006720; GO:0046872; GO:0097089; GO:0005739; GO:0005777; GO:0048244 L-ascorbic acid binding; cofactor binding; fatty acid alpha-oxidation; isoprenoid metabolic process; metal ion binding; methyl-branched fatty acid metabolic process; mitochondrion; peroxisome; phytanoyl-CoA dioxygenase activity IPR008775; Lipid metabolism; fatty acid metabolism. "Phytanoyl-CoA dioxygenase, peroxisomal (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH)" Phyh Rattus norvegicus (Rat) TR27452_c0_g1_i2 O18778 PAHX_BOVIN 2.00E-111 GO:0031418; GO:0006631; GO:0046872; GO:0005777; GO:0048244 L-ascorbic acid binding; fatty acid metabolic process; metal ion binding; peroxisome; phytanoyl-CoA dioxygenase activity IPR008775; Lipid metabolism; fatty acid metabolism. "Phytanoyl-CoA dioxygenase, peroxisomal (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH)" PHYH LN1 PAHX Bos taurus (Bovine) TR27456_c1_g1_i2 P70031 CCKAR_XENLA 1.00E-10 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR009126; IPR000276; IPR017452; Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) TR27456_c1_g1_i3 P70031 CCKAR_XENLA 1.00E-10 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR009126; IPR000276; IPR017452; Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) TR27457_c0_g1_i1 Q6RUV5 RAC1_RAT 2.00E-35 GO:0005525; GO:0003924; GO:0000139; GO:0016601; GO:0060071; GO:0007015; GO:0048532; GO:0002093; GO:0007411; GO:0045453; GO:0008283; GO:0045216; GO:0021799; GO:0090103; GO:0031410; GO:0048813; GO:0071542; GO:0021831; GO:0043652; GO:0003382; GO:0019897; GO:0006972; GO:0030027; GO:0030032; GO:0002551; GO:0042470; GO:0001891; GO:0045740; GO:0030838; GO:0043552; GO:0001934; GO:0030334; GO:0097178; GO:0032587; GO:0034446 "GTP binding; GTPase activity; Golgi membrane; Rac protein signal transduction; Wnt receptor signaling pathway, planar cell polarity pathway; actin filament organization; anatomical structure arrangement; auditory receptor cell morphogenesis; axon guidance; bone resorption; cell proliferation; cell-cell junction organization; cerebral cortex radially oriented cell migration; cochlea morphogenesis; cytoplasmic vesicle; dendrite morphogenesis; dopaminergic neuron differentiation; embryonic olfactory bulb interneuron precursor migration; engulfment of apoptotic cell; epithelial cell morphogenesis; extrinsic to plasma membrane; hyperosmotic response; lamellipodium; lamellipodium assembly; mast cell chemotaxis; melanosome; phagocytic cup; positive regulation of DNA replication; positive regulation of actin filament polymerization; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein phosphorylation; regulation of cell migration; ruffle assembly; ruffle membrane; substrate adhesion-dependent cell spreading" IPR027417; IPR005225; IPR001806; IPR003578; Ras-related C3 botulinum toxin substrate 1 (p21-Rac1) Rac1 Rattus norvegicus (Rat) TR27459_c1_g1_i1 O59826 KCAB_SCHPO 3.00E-43 GO:0005829; GO:0016021; GO:0005634; GO:0006813; GO:0005244 cytosol; integral to membrane; nucleus; potassium ion transport; voltage-gated ion channel activity IPR001395; IPR005399; IPR005400; IPR023210; Putative voltage-gated potassium channel subunit beta (K(+) channel subunit beta) SPCC965.06 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR27459_c1_g1_i2 P63144 KCAB1_RAT 4.00E-81 GO:0005737; GO:0016021; GO:0005249 cytoplasm; integral to membrane; voltage-gated potassium channel activity IPR001395; IPR005983; IPR005399; IPR005400; IPR023210; Voltage-gated potassium channel subunit beta-1 (K(+) channel subunit beta-1) (Kv-beta-1) Kcnab1 Kvb1 Rattus norvegicus (Rat) TR27459_c1_g1_i3 P97382 KCAB3_MOUSE 3.00E-44 GO:0005737; GO:0016021; GO:0005249 Q9JIP4 cytoplasm; integral to membrane; voltage-gated potassium channel activity IPR001395; IPR005983; IPR005399; IPR005402; IPR023210; Voltage-gated potassium channel subunit beta-3 (K(+) channel subunit beta-3) (Kv-beta-3) Kcnab3 Mus musculus (Mouse) TR27459_c2_g1_i1 Q13303 KCAB2_HUMAN 3.00E-29 GO:0005737; GO:0016021; GO:0044224; GO:0005886; GO:0015459; GO:0051291; GO:0007268; GO:0005249 cytoplasm; integral to membrane; juxtaparanode region of axon; plasma membrane; potassium channel regulator activity; protein heterooligomerization; synaptic transmission; voltage-gated potassium channel activity IPR001395; IPR005983; IPR005399; IPR005401; IPR023210; Voltage-gated potassium channel subunit beta-2 (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2) KCNAB2 KCNA2B KCNK2 Homo sapiens (Human) TR27459_c2_g1_i4 O05408 YRPG_BACSU 5.00E-07 GO:0016491 oxidoreductase activity IPR001395; IPR023210; Uncharacterized oxidoreductase YrpG (EC 1.-.-.-) yrpG BSU26850 Bacillus subtilis (strain 168) TR27460_c1_g1_i1 Q3U288 ZN710_MOUSE 2.00E-09 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 710 Znf710 Zfp710 Mus musculus (Mouse) TR27460_c1_g1_i2 P31629 ZEP2_HUMAN 1.00E-06 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) HIVEP2 Homo sapiens (Human) TR27460_c1_g2_i1 B2RRE4 Z518B_MOUSE 2.00E-06 GO:0003677; GO:0046872; GO:0005634; GO:0000981 DNA binding; metal ion binding; nucleus; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR007087; IPR015880; Zinc finger protein 518B Znf518b Kiaa1729 Zfp518b Mus musculus (Mouse) TR27462_c0_g1_i1 A9KJH8 RL18_CLOPH 3.00E-06 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR005484; IPR004389; 50S ribosomal protein L18 rplR Cphy_3651 Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) TR27462_c0_g1_i3 Q9H0U6 RM18_HUMAN 1.00E-33 GO:0008097; GO:0005761; GO:0035928; GO:0003735; GO:0006412 5S rRNA binding; mitochondrial ribosome; rRNA import into mitochondrion; structural constituent of ribosome; translation IPR005484; "39S ribosomal protein L18, mitochondrial (L18mt) (MRP-L18)" MRPL18 HSPC071 Homo sapiens (Human) TR27462_c0_g1_i4 Q5E898 RL18_VIBF1 2.00E-08 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR005484; IPR004389; 50S ribosomal protein L18 rplR VF_0253 Vibrio fischeri (strain ATCC 700601 / ES114) TR27463_c0_g1_i2 Q5JTJ3 CA031_HUMAN 5.00E-14 GO:0004129; GO:0005739 cytochrome-c oxidase activity; mitochondrion IPR003213; Cytochrome c oxidase assembly factor 6 homolog COA6 C1orf31 Homo sapiens (Human) TR27464_c0_g2_i1 Q16281 CNGA3_HUMAN 2.00E-140 GO:0030553; GO:0005887; GO:0005222; GO:0005223; GO:0001750; GO:0007603; GO:0042391; GO:0046549; GO:0007601; GO:0005249 "cGMP binding; integral to plasma membrane; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; photoreceptor outer segment; phototransduction, visible light; regulation of membrane potential; retinal cone cell development; visual perception; voltage-gated potassium channel activity" IPR018490; IPR018488; IPR000595; IPR005821; IPR014710; Cyclic nucleotide-gated cation channel alpha-3 (Cone photoreceptor cGMP-gated channel subunit alpha) (Cyclic nucleotide-gated channel alpha-3) (CNG channel alpha-3) (CNG-3) (CNG3) CNGA3 CNCG3 Homo sapiens (Human) TR27469_c0_g1_i1 O43704 ST1B1_HUMAN 2.00E-33 GO:0050427; GO:0004062; GO:0006576; GO:0005829; GO:0009812; GO:0008202; GO:0051923; GO:0008146; GO:0042403; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; aryl sulfotransferase activity; cellular biogenic amine metabolic process; cytosol; flavonoid metabolic process; steroid metabolic process; sulfation; sulfotransferase activity; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) (Sulfotransferase 1B2) (ST1B2) (Thyroid hormone sulfotransferase) SULT1B1 ST1B2 SULT1B2 Homo sapiens (Human) TR27469_c0_g2_i1 O43704 ST1B1_HUMAN 5.00E-14 GO:0050427; GO:0004062; GO:0006576; GO:0005829; GO:0009812; GO:0008202; GO:0051923; GO:0008146; GO:0042403; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; aryl sulfotransferase activity; cellular biogenic amine metabolic process; cytosol; flavonoid metabolic process; steroid metabolic process; sulfation; sulfotransferase activity; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) (Sulfotransferase 1B2) (ST1B2) (Thyroid hormone sulfotransferase) SULT1B1 ST1B2 SULT1B2 Homo sapiens (Human) TR27473_c0_g1_i1 P12659 HCYA_ENTDO 2.00E-127 GO:0046872; GO:0055114; GO:0016491; GO:0005344 metal ion binding; oxidation-reduction process; oxidoreductase activity; oxygen transporter activity IPR002227; IPR008922; "Hemocyanin A-type, units Ode to Odg (Fragment)" Enteroctopus dofleini (Giant octopus) (Octopus dofleini) TR27474_c3_g1_i1 Q8BYN3 ITPK1_MOUSE 4.00E-67 GO:0005524; GO:0016787; GO:0047325; GO:0032957; GO:0052726; GO:0052725; GO:0005622; GO:0016853; GO:0000287 "ATP binding; hydrolase activity; inositol tetrakisphosphate 1-kinase activity; inositol trisphosphate metabolic process; inositol-1,3,4-trisphosphate 5-kinase activity; inositol-1,3,4-trisphosphate 6-kinase activity; intracellular; isomerase activity; magnesium ion binding" IPR011761; IPR008656; "Inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134) (Inositol 1,3,4-trisphosphate 5/6-kinase) (Inositol-triphosphate 5/6-kinase) (Ins(1,3,4)P(3) 5/6-kinase) (EC 2.7.1.159)" Itpk1 Mus musculus (Mouse) TR27475_c1_g1_i1 Q8N682 DRAM1_HUMAN 8.00E-11 GO:0030262; GO:0006914; GO:0016021; GO:0005765; GO:0005764 apoptotic nuclear changes; autophagy; integral to membrane; lysosomal membrane; lysosome IPR027315; IPR019402; DNA damage-regulated autophagy modulator protein 1 (Damage-regulated autophagy modulator) DRAM1 DRAM Homo sapiens (Human) TR27475_c1_g1_i2 Q9CR48 DRAM2_MOUSE 3.00E-10 GO:0005794; GO:0030262; GO:0097194; GO:0016021; GO:0005765; GO:0005764 Golgi apparatus; apoptotic nuclear changes; execution phase of apoptosis; integral to membrane; lysosomal membrane; lysosome IPR027315; IPR019402; DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77) Dram2 Tmem77 Mus musculus (Mouse) TR27475_c1_g1_i3 Q9DC58 DRAM1_MOUSE 3.00E-09 GO:0030262; GO:0006914; GO:0016021; GO:0005765 apoptotic nuclear changes; autophagy; integral to membrane; lysosomal membrane IPR027315; IPR019402; DNA damage-regulated autophagy modulator protein 1 (Damage-regulated autophagy modulator) Dram1 Dram Mus musculus (Mouse) TR27476_c0_g1_i1 P49395 RS3A_APLCA 3.00E-155 GO:0022627; GO:0003735; GO:0006412 cytosolic small ribosomal subunit; structural constituent of ribosome; translation IPR027500; IPR001593; IPR018281; 40S ribosomal protein S3a (Lysine-rich protein KRP-A) RPS3A KRP-A Aplysia californica (California sea hare) TR27479_c0_g1_i2 Q9Y586 MB212_HUMAN 4.00E-16 GO:0043010; GO:0010172; GO:0048568; GO:0007399; GO:0005634; GO:0008284 camera-type eye development; embryonic body morphogenesis; embryonic organ development; nervous system development; nucleus; positive regulation of cell proliferation IPR024810; IPR024801; IPR000772; Protein mab-21-like 2 MAB21L2 Homo sapiens (Human) TR27483_c0_g1_i1 A4QP81 FRRS1_DANRE 2.00E-17 GO:0016021; GO:0016491 integral to membrane; oxidoreductase activity IPR006593; IPR005018; IPR002861; Putative ferric-chelate reductase 1 (EC 1.-.-.-) frrs1 zgc:163022 Danio rerio (Zebrafish) (Brachydanio rerio) TR27483_c0_g1_i3 A4QP81 FRRS1_DANRE 3.00E-17 GO:0016021; GO:0016491 integral to membrane; oxidoreductase activity IPR006593; IPR005018; IPR002861; Putative ferric-chelate reductase 1 (EC 1.-.-.-) frrs1 zgc:163022 Danio rerio (Zebrafish) (Brachydanio rerio) TR27486_c3_g1_i1 Q9TZM3 LRK1_CAEEL 6.00E-06 GO:0005524; GO:0005525; GO:0005794; GO:0048846; GO:0034613; GO:0046872; GO:0043025; GO:0004674; GO:0034976; GO:0006979; GO:0007264; GO:0048489 ATP binding; GTP binding; Golgi apparatus; axon extension involved in axon guidance; cellular protein localization; metal ion binding; neuronal cell body; protein serine/threonine kinase activity; response to endoplasmic reticulum stress; response to oxidative stress; small GTPase mediated signal transduction; synaptic vesicle transport IPR002110; IPR020683; IPR011009; IPR001611; IPR003591; IPR013684; IPR027417; IPR000719; IPR020859; IPR017986; "Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) (Leucine-rich repeats, ras-like domain, kinase protein 1) (PARK8-related kinase)" lrk-1 T27C10.6 Caenorhabditis elegans TR27486_c3_g1_i2 Q12955 ANK3_HUMAN 9.00E-12 GO:0043001; GO:0030315; GO:0007411; GO:0043194; GO:0007409; GO:0016323; GO:0045296; GO:0009986; GO:0043034; GO:0014704; GO:0044325; GO:0016328; GO:0005764; GO:0072660; GO:0071709; GO:0000281; GO:0033268; GO:0033270; GO:0010628; GO:1900827; GO:0045838; GO:2000651; GO:0010765; GO:0045211; GO:0030674; GO:0072661; GO:0019228; GO:0043266; GO:0007165; GO:0030507; GO:0014731; GO:0005200; GO:0050808 "Golgi to plasma membrane protein transport; T-tubule; axon guidance; axon initial segment; axonogenesis; basolateral plasma membrane; cadherin binding; cell surface; costamere; intercalated disc; ion channel binding; lateral plasma membrane; lysosome; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; node of Ranvier; paranode region of axon; positive regulation of gene expression; positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; postsynaptic membrane; protein binding, bridging; protein targeting to plasma membrane; regulation of action potential in neuron; regulation of potassium ion transport; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton; synapse organization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) TR27486_c3_g1_i4 Q07E15 CTTB2_MUSPF 3.00E-12 GO:0005938; GO:0043197 cell cortex; dendritic spine IPR002110; IPR020683; IPR019131; Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Mustela putorius furo (European domestic ferret) (Mustela furo) TR27486_c3_g1_i6 Q69ZU8 ANKR6_MOUSE 6.00E-14 GO:0005737; GO:0090090; GO:0005634; GO:0046330; GO:2000096 "cytoplasm; negative regulation of canonical Wnt receptor signaling pathway; nucleus; positive regulation of JNK cascade; positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway" IPR002110; IPR020683; Ankyrin repeat domain-containing protein 6 (Diversin) Ankrd6 Kiaa0957 Mus musculus (Mouse) TR27488_c0_g1_i1 P70082 H2AJ_CHICK 7.00E-42 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR002119; Histone H2A.J (H2a/j) (Histone H2A-IX) H2A-IX Gallus gallus (Chicken) TR27491_c1_g1_i1 Q6XPS3 TPTE2_HUMAN 9.00E-79 GO:0000139; GO:0005789; GO:0016021; GO:0005216; GO:0035335; GO:0006661; GO:0016314; GO:0004725; GO:0008138; GO:0044281 "Golgi membrane; endoplasmic reticulum membrane; integral to membrane; ion channel activity; peptidyl-tyrosine dephosphorylation; phosphatidylinositol biosynthetic process; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; small molecule metabolic process" IPR000008; IPR000340; IPR005821; IPR014019; IPR014020; IPR016130; "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (Lipid phosphatase TPIP) (TPTE and PTEN homologous inositol lipid phosphatase)" TPTE2 TPIP Homo sapiens (Human) TR27491_c1_g3_i1 Q8T9S7 PTEN_DICDI 3.00E-44 GO:0007015; GO:0007188; GO:0031152; GO:0051285; GO:0006928; GO:0043327; GO:0005829; GO:0030010; GO:0008289; GO:0000281; GO:0050919; GO:0071901; GO:0035335; GO:0046856; GO:0016314; GO:0048015; GO:0005886; GO:0051272; GO:0036051; GO:0004725; GO:0045761; GO:0022604; GO:0031272; GO:0031254 "actin filament organization; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; aggregation involved in sorocarp development; cell cortex of cell tip; cellular component movement; chemotaxis to cAMP; cytosol; establishment of cell polarity; lipid binding; mitotic cytokinesis; negative chemotaxis; negative regulation of protein serine/threonine kinase activity; peptidyl-tyrosine dephosphorylation; phosphatidylinositol dephosphorylation; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-mediated signaling; plasma membrane; positive regulation of cellular component movement; protein localization to trailing edge; protein tyrosine phosphatase activity; regulation of adenylate cyclase activity; regulation of cell morphogenesis; regulation of pseudopodium assembly; trailing edge" IPR000008; IPR014019; IPR014020; IPR016130; "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Pten 3-phosphoinositide phosphatase alpha)" pteN ptenA DDB_G0286557 Dictyostelium discoideum (Slime mold) TR27494_c2_g2_i1 O50655 XERD_SELRU 9.00E-07 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR27495_c0_g1_i1 P37153 APOD_RABIT 1.00E-18 GO:0007568; GO:0007420; GO:0015485; GO:0022626; GO:0030425; GO:0005783; GO:0005615; GO:0006006; GO:0006629; GO:2000405; GO:1900016; GO:0051895; GO:0060588; GO:0071638; GO:0010642; GO:0042308; GO:0048662; GO:2000098; GO:0043025; GO:0048471; GO:0014012; GO:0042493; GO:0000302; GO:0042246; GO:0005215 aging; brain development; cholesterol binding; cytosolic ribosome; dendrite; endoplasmic reticulum; extracellular space; glucose metabolic process; lipid metabolic process; negative regulation of T cell migration; negative regulation of cytokine production involved in inflammatory response; negative regulation of focal adhesion assembly; negative regulation of lipoprotein lipid oxidation; negative regulation of monocyte chemotactic protein-1 production; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein import into nucleus; negative regulation of smooth muscle cell proliferation; negative regulation of smooth muscle cell-matrix adhesion; neuronal cell body; perinuclear region of cytoplasm; peripheral nervous system axon regeneration; response to drug; response to reactive oxygen species; tissue regeneration; transporter activity IPR026222; IPR002969; IPR012674; IPR011038; IPR022271; IPR022272; IPR000566; Apolipoprotein D (Apo-D) (ApoD) APOD Oryctolagus cuniculus (Rabbit) TR27496_c1_g1_i1 Q68CP4 HGNAT_HUMAN 5.00E-41 GO:0005975; GO:0006027; GO:0015019; GO:0016021; GO:0005765; GO:0007041; GO:0051259; GO:0044281; GO:0016746 "carbohydrate metabolic process; glycosaminoglycan catabolic process; heparan-alpha-glucosaminide N-acetyltransferase activity; integral to membrane; lysosomal membrane; lysosomal transport; protein oligomerization; small molecule metabolic process; transferase activity, transferring acyl groups" IPR012429; Heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) (Transmembrane protein 76) HGSNAT TMEM76 Homo sapiens (Human) TR27496_c4_g1_i1 A1L3I5 NSAPC_XENLA 3.00E-09 GO:0003677; GO:0005737; GO:0040001; GO:0007126; GO:0005874; GO:0007067; GO:0000281; GO:0005634; GO:0005819 DNA binding; cytoplasm; establishment of mitotic spindle localization; meiosis; microtubule; mitosis; mitotic cytokinesis; nucleus; spindle IPR026756; Nucleolar and spindle-associated protein 1-C (NuSAP C) nusap1-c Xenopus laevis (African clawed frog) TR27496_c4_g1_i3 A1L2F3 NUSAP_DANRE 8.00E-19 GO:0003677; GO:0005737; GO:0040001; GO:0005874; GO:0007067; GO:0000281; GO:0001755; GO:0005634; GO:0005819 DNA binding; cytoplasm; establishment of mitotic spindle localization; microtubule; mitosis; mitotic cytokinesis; neural crest cell migration; nucleus; spindle IPR026756; Nucleolar and spindle-associated protein 1 (NuSAP) nusap1 Danio rerio (Zebrafish) (Brachydanio rerio) TR27497_c1_g1_i1 Q13416 ORC2_HUMAN 5.00E-137 GO:0006270; GO:0003688; GO:0000082; GO:0000939; GO:0000792; GO:0000122; GO:0005664; GO:0005654 Q99459; P03211; Q7L590; P25205; Q13415; O43929; O43913; Q15554 DNA replication initiation; DNA replication origin binding; G1/S transition of mitotic cell cycle; condensed chromosome inner kinetochore; heterochromatin; negative regulation of transcription from RNA polymerase II promoter; nuclear origin of replication recognition complex; nucleoplasm IPR007220; Origin recognition complex subunit 2 ORC2 ORC2L Homo sapiens (Human) TR27501_c0_g1_i1 D4A8G9 ZFY26_RAT 3.00E-18 GO:0006281; GO:0005813; GO:0000910; GO:0005737; GO:0046872; GO:0030496; GO:0032266 DNA repair; centrosome; cytokinesis; cytoplasm; metal ion binding; midbody; phosphatidylinositol-3-phosphate binding IPR000306; IPR017455; IPR011011; IPR013083; Zinc finger FYVE domain-containing protein 26 Zfyve26 Rattus norvegicus (Rat) TR27501_c1_g1_i2 D4A8G9 ZFY26_RAT 4.00E-37 GO:0006281; GO:0005813; GO:0000910; GO:0005737; GO:0046872; GO:0030496; GO:0032266 DNA repair; centrosome; cytokinesis; cytoplasm; metal ion binding; midbody; phosphatidylinositol-3-phosphate binding IPR000306; IPR017455; IPR011011; IPR013083; Zinc finger FYVE domain-containing protein 26 Zfyve26 Rattus norvegicus (Rat) TR27506_c0_g1_i1 D2KQB0 HHEX_ASTMI 2.00E-51 GO:0007275; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR020479; IPR009057; Hematopoietically-expressed homeobox protein HHEX homolog (AmHEX) (Homeobox protein HEX) (HEX homeodomain transcription factor) hhex hex Patiria miniata (Bat star) (Asterina miniata) TR27508_c0_g1_i1 Q9YGM8 CAV1_TAKRU 3.00E-39 GO:0000139; GO:0031295; GO:0005901; GO:0005783; GO:0005768; GO:0005198 Golgi membrane; T cell costimulation; caveola; endoplasmic reticulum; endosome; structural molecule activity IPR001612; IPR015504; IPR018361; Caveolin-1 cav1 cav-1 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR27510_c0_g1_i1 Q6AZB8 HARB1_DANRE 6.00E-11 GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) TR27515_c5_g1_i1 Q9XT10 GTR4_PIG 2.00E-27 GO:0032869; GO:0012505; GO:0005355; GO:0015758; GO:0032593; GO:0016021; GO:0048471; GO:0005886 cellular response to insulin stimulus; endomembrane system; glucose transmembrane transporter activity; glucose transport; insulin-responsive compartment; integral to membrane; perinuclear region of cytoplasm; plasma membrane IPR002441; IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4) (Fragment)" SLC2A4 GLUT4 Sus scrofa (Pig) TR27515_c6_g1_i1 P47842 GTR3_CANFA 9.00E-84 GO:0005355; GO:0015758; GO:0016021 glucose transmembrane transporter activity; glucose transport; integral to membrane IPR002945; IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3)" SLC2A3 GLUT3 Canis familiaris (Dog) (Canis lupus familiaris) TR27515_c6_g1_i2 Q8IRI6 GTR1_DROME 2.00E-59 GO:0008643; GO:0016021; GO:0022891 carbohydrate transport; integral to membrane; substrate-specific transmembrane transporter activity IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; Glucose transporter type 1 Glut1 CG43946 Drosophila melanogaster (Fruit fly) TR27515_c7_g1_i1 P23708 NFYA_MOUSE 1.00E-26 GO:0016602; GO:0003677; GO:0005654; GO:2000648; GO:0045944; GO:2000036; GO:0003700; GO:0006351 P08047 "CCAAT-binding factor complex; DNA binding; nucleoplasm; positive regulation of stem cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of stem cell maintenance; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR018362; IPR001289; Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) Nfya Mus musculus (Mouse) TR27515_c7_g1_i2 P23708 NFYA_MOUSE 7.00E-27 GO:0016602; GO:0003677; GO:0005654; GO:2000648; GO:0045944; GO:2000036; GO:0003700; GO:0006351 P08047 "CCAAT-binding factor complex; DNA binding; nucleoplasm; positive regulation of stem cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of stem cell maintenance; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR018362; IPR001289; Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) Nfya Mus musculus (Mouse) TR27524_c3_g1_i1 O70165 FCN1_MOUSE 2.00E-19 GO:0005581; GO:0045087; GO:0046872 collagen; innate immune response; metal ion binding IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) Fcn1 Fcna Mus musculus (Mouse) TR27524_c4_g1_i1 Q8VCM7 FIBG_MOUSE 4.00E-07 GO:0005938; GO:0009897; GO:0005577; GO:0046872; GO:0030168; GO:0031091; GO:0051258; GO:0051592; GO:0007165 cell cortex; external side of plasma membrane; fibrinogen complex; metal ion binding; platelet activation; platelet alpha granule; protein polymerization; response to calcium ion; signal transduction IPR014716; IPR014715; IPR002181; IPR012290; IPR020837; Fibrinogen gamma chain Fgg Mus musculus (Mouse) TR27525_c0_g1_i1 Q9QYG6 CP2DR_MESAU 7.00E-88 GO:0005789; GO:0020037; GO:0005506; GO:0016712 "endoplasmic reticulum membrane; heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen" IPR001128; IPR017972; IPR002401; IPR008069; Cytochrome P450 2D27 (EC 1.14.14.-) (CYPIID27) CYP2D27 Mesocricetus auratus (Golden hamster) TR27525_c0_g1_i2 P11372 CP2CF_RABIT 5.00E-61 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 2C15 (EC 1.14.14.1) (CYPIIC15) (Cytochrome P450 B32-3) (Fragment) CYP2C15 Oryctolagus cuniculus (Rabbit) TR27531_c0_g1_i1 P43218 GIPR_MESAU 8.00E-29 GO:0016519; GO:0038192; GO:0016021; GO:0005886 gastric inhibitory peptide receptor activity; gastric inhibitory peptide signaling pathway; integral to membrane; plasma membrane IPR017981; IPR001879; IPR001749; IPR000832; IPR017983; Gastric inhibitory polypeptide receptor (GIP-R) (Glucose-dependent insulinotropic polypeptide receptor) GIPR Mesocricetus auratus (Golden hamster) TR27531_c1_g2_i1 P49190 PTH2R_HUMAN 4.00E-38 GO:0005887; GO:0004991 integral to plasma membrane; parathyroid hormone receptor activity IPR017981; IPR001879; IPR000832; IPR017983; Parathyroid hormone 2 receptor (PTH2 receptor) PTH2R PTHR2 Homo sapiens (Human) TR27532_c0_g1_i2 Q9H299 SH3L3_HUMAN 6.00E-23 GO:0045454; GO:0005737; GO:0009055; GO:0005634; GO:0015035 cell redox homeostasis; cytoplasm; electron carrier activity; nucleus; protein disulfide oxidoreductase activity IPR006993; IPR002109; IPR012336; SH3 domain-binding glutamic acid-rich-like protein 3 (SH3 domain-binding protein 1) (SH3BP-1) SH3BGRL3 P1725 Homo sapiens (Human) TR27535_c0_g1_i1 Q6NXN4 D19P1_HUMAN 4.00E-36 GO:0016021; GO:0016757 "integral to membrane; transferase activity, transferring glycosyl groups" IPR018732; Putative C-mannosyltransferase DPY19L2P1 (EC 2.4.1.-) (Dpy-19-like protein 2 pseudogene 1) (Protein dpy-19 homolog 2-like 1) DPY19L2P1 Homo sapiens (Human) TR27535_c0_g2_i1 Q2PZI1 D19L1_HUMAN 7.00E-146 GO:0016021; GO:0016757 "integral to membrane; transferase activity, transferring glycosyl groups" IPR018732; Probable C-mannosyltransferase DPY19L1 (EC 2.4.1.-) (Dpy-19-like protein 1) (Protein dpy-19 homolog 1) DPY19L1 GA0500 KIAA0877 Homo sapiens (Human) TR27535_c0_g2_i2 Q9VWR8 DPY19_DROME 4.00E-26 GO:0016021; GO:0016757 Q9VW68 "integral to membrane; transferase activity, transferring glycosyl groups" IPR018732; C-mannosyltransferase dpy-19 homolog (EC 2.4.1.-) CG6659 Drosophila melanogaster (Fruit fly) TR27535_c0_g2_i3 Q2PZI1 D19L1_HUMAN 6.00E-133 GO:0016021; GO:0016757 "integral to membrane; transferase activity, transferring glycosyl groups" IPR018732; Probable C-mannosyltransferase DPY19L1 (EC 2.4.1.-) (Dpy-19-like protein 1) (Protein dpy-19 homolog 1) DPY19L1 GA0500 KIAA0877 Homo sapiens (Human) TR27538_c0_g1_i1 Q6DHL5 LRC57_DANRE 2.00E-11 IPR001611; IPR025875; Leucine-rich repeat-containing protein 57 lrrc57 zgc:92240 Danio rerio (Zebrafish) (Brachydanio rerio) TR27538_c1_g1_i1 Q3V1N1 MFHA1_MOUSE 2.00E-13 IPR001611; IPR025875; IPR003591; IPR027417; IPR020859; Malignant fibrous histiocytoma-amplified sequence 1 homolog Mfhas1 Mus musculus (Mouse) TR27538_c3_g1_i1 Q921G6 LRCH4_MOUSE 7.00E-06 IPR001715; IPR001611; IPR025875; IPR003591; Leucine-rich repeat and calponin homology domain-containing protein 4 Lrch4 Mus musculus (Mouse) TR27538_c3_g2_i1 Q01631 CYAA_NEUCR 6.00E-16 GO:0005524; GO:0004016; GO:0035556; GO:0000287 ATP binding; adenylate cyclase activity; intracellular signal transduction; magnesium ion binding IPR001054; IPR013716; IPR001611; IPR025875; IPR003591; IPR001932; IPR000159; Adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl cyclase) cr-1 nac NCU08377 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR27539_c0_g1_i1 Q8A800 DCDA_BACTN 9.00E-07 GO:0008836; GO:0009089; GO:0030170 diaminopimelate decarboxylase activity; lysine biosynthetic process via diaminopimelate; pyridoxal phosphate binding IPR009006; IPR002986; IPR022643; IPR022644; IPR022653; IPR000183; "Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1." Diaminopimelate decarboxylase (DAP decarboxylase) (DAPDC) (EC 4.1.1.20) lysA BT_1374 Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) TR27539_c0_g1_i3 P07805 DCOR_TRYBB 3.00E-106 GO:0004586; GO:0033387 ornithine decarboxylase activity; putrescine biosynthetic process from ornithine IPR009006; IPR022643; IPR022644; IPR022653; IPR000183; IPR002433; Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1. Ornithine decarboxylase (ODC) (EC 4.1.1.17) Trypanosoma brucei brucei TR27539_c0_g1_i4 P09057 DCOR_RAT 1.00E-114 GO:0005829; GO:0001822; GO:0004586; GO:0048471; GO:0008284; GO:0009446; GO:0033387; GO:0009615 cytosol; kidney development; ornithine decarboxylase activity; perinuclear region of cytoplasm; positive regulation of cell proliferation; putrescine biosynthetic process; putrescine biosynthetic process from ornithine; response to virus IPR009006; IPR022643; IPR022657; IPR022644; IPR022653; IPR000183; IPR002433; Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1. Ornithine decarboxylase (ODC) (EC 4.1.1.17) Odc1 Odc Rattus norvegicus (Rat) TR27540_c0_g2_i1 Q9R044 NPHN_RAT 9.00E-07 GO:0007155; GO:0003094; GO:0016021; GO:0045121; GO:0007517; GO:0005886; GO:0043234; GO:0036057 P97710 cell adhesion; glomerular filtration; integral to membrane; membrane raft; muscle organ development; plasma membrane; protein complex; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Rattus norvegicus (Rat) TR27541_c5_g1_i1 O17583 LIN10_CAEEL 5.00E-56 GO:0032580; GO:0000138; GO:0008105; GO:0007275; GO:0043005; GO:0007270; GO:0043025; GO:0005886; GO:0040026; GO:0050975; GO:0030140 Q19955; O01427; O45952; P54936; O62482 Golgi cisterna membrane; Golgi trans cisterna; asymmetric protein localization; multicellular organismal development; neuron projection; neuron-neuron synaptic transmission; neuronal cell body; plasma membrane; positive regulation of vulval development; sensory perception of touch; trans-Golgi network transport vesicle IPR001478; IPR011993; IPR006020; Protein lin-10 (Abnormal cell lineage protein 10) lin-10 C09H6.2 Caenorhabditis elegans TR27542_c0_g1_i1 P60843 IF4A1_MOUSE 0 GO:0005524; GO:0008026; GO:0003725; GO:0003743 Q6NZJ6; Q61823 ATP binding; ATP-dependent helicase activity; double-stranded RNA binding; translation initiation factor activity IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) Eif4a1 Ddx2a Eif4a Mus musculus (Mouse) TR27542_c0_g2_i1 Q2HCV7 ROK1_CHAGB 8.00E-09 GO:0005524; GO:0008026; GO:0003723; GO:0005730; GO:0006364 ATP binding; ATP-dependent helicase activity; RNA binding; nucleolus; rRNA processing IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; ATP-dependent RNA helicase ROK1 (EC 3.6.4.13) ROK1 CHGG_01947 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) TR27542_c0_g3_i1 Q9CL21 RECQ_PASMU 3.00E-10 GO:0005524; GO:0043140; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0009432; GO:0005622 ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA binding; DNA recombination; DNA repair; DNA replication; SOS response; intracellular IPR011545; IPR004589; IPR006293; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR018982; IPR011991; ATP-dependent DNA helicase RecQ (EC 3.6.4.12) recQ PM1427 Pasteurella multocida (strain Pm70) TR27546_c0_g1_i1 Q32NW2 LENG8_XENLA 2.00E-10 IPR005062; Leukocyte receptor cluster member 8 homolog leng8 Xenopus laevis (African clawed frog) TR27548_c0_g1_i1 Q9Y5B8 NDK7_HUMAN 9.00E-146 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0007420; GO:0005813; GO:0060830; GO:0007368; GO:0003351; GO:0042073; GO:0060972; GO:0046872; GO:0004550 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; brain development; centrosome; ciliary receptor clustering involved in smoothened signaling pathway; determination of left/right symmetry; epithelial cilium movement; intraflagellar transport; left/right pattern formation; metal ion binding; nucleoside diphosphate kinase activity IPR011410; IPR001564; IPR006602; Nucleoside diphosphate kinase 7 (NDK 7) (NDP kinase 7) (EC 2.7.4.6) (nm23-H7) NME7 Homo sapiens (Human) TR27549_c1_g1_i1 P59240 NPHP4_MOUSE 5.00E-11 GO:0005911; GO:0005813; GO:0005929; GO:0005737; GO:0005932; GO:0060041; GO:0005923 Q9QY53; Q8CG73 cell-cell junction; centrosome; cilium; cytoplasm; microtubule basal body; retina development in camera-type eye; tight junction Nephrocystin-4 (Nephroretinin) Nphp4 Mus musculus (Mouse) TR27556_c2_g1_i1 Q9VUX2 MIB_DROME 5.00E-13 GO:0007219; GO:0045179; GO:0005829; GO:0006897; GO:0046331; GO:0045747; GO:0008104; GO:0007423; GO:0004842; GO:0008270 Notch signaling pathway; apical cortex; cytosol; endocytosis; lateral inhibition; positive regulation of Notch signaling pathway; protein localization; sensory organ development; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase mind-bomb (EC 6.3.2.-) (Mind bomb homolog) (D-mib) mib1 mind-bomb CG5841 Drosophila melanogaster (Fruit fly) TR27556_c2_g1_i2 Q96AX9 MIB2_HUMAN 3.00E-15 GO:0007219; GO:0005768; GO:0043123; GO:0004871; GO:0004842; GO:0008270 Q9UHD2 Notch signaling pathway; endosome; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1) MIB2 SKD ZZANK1 Homo sapiens (Human) TR27559_c5_g1_i1 F4KD71 DUR3_ARATH 2.00E-25 GO:0016021; GO:0005886; GO:0015293; GO:0015204 integral to membrane; plasma membrane; symporter activity; urea transmembrane transporter activity IPR001734; IPR019900; Urea-proton symporter DUR3 (AtDUR3) (High-affinity urea active transporter DUR3) DUR3 At5g45380 MFC19.5 Arabidopsis thaliana (Mouse-ear cress) TR27561_c0_g1_i1 Q01289 POR_PEA 3.00E-13 GO:0015995; GO:0009507; GO:0015979; GO:0016630 chlorophyll biosynthetic process; chloroplast; photosynthesis; protochlorophyllide reductase activity IPR002198; IPR002347; IPR016040; IPR005979; Porphyrin-containing compound metabolism; chlorophyll biosynthesis. "Protochlorophyllide reductase, chloroplastic (PCR) (EC 1.3.1.33) (NADPH-protochlorophyllide oxidoreductase) (POR)" 3PCR Pisum sativum (Garden pea) TR27561_c0_g2_i1 A6QP05 DHR12_BOVIN 2.00E-16 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; Dehydrogenase/reductase SDR family member 12 (EC 1.1.-.-) DHRS12 Bos taurus (Bovine) TR27561_c2_g1_i1 Q8TC12 RDH11_HUMAN 8.00E-54 GO:0052650; GO:0005789; GO:0016021; GO:0007603; GO:0042574; GO:0004745 "NADP-retinol dehydrogenase activity; endoplasmic reticulum membrane; integral to membrane; phototransduction, visible light; retinal metabolic process; retinol dehydrogenase activity" IPR002198; IPR002347; IPR016040; Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) RDH11 ARSDR1 PSDR1 CGI-82 Homo sapiens (Human) TR27563_c0_g1_i1 B0JZG0 S23A2_XENTR 1.00E-112 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR006042; IPR006043; Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR27564_c0_g1_i1 Q8WXI8 CLC4D_HUMAN 3.00E-15 GO:0030246; GO:0045087; GO:0016021 carbohydrate binding; innate immune response; integral to membrane IPR001304; IPR016186; IPR016187; C-type lectin domain family 4 member D (C-type lectin superfamily member 8) (C-type lectin-like receptor 6) (CLEC-6) CLEC4D CLECSF8 MCL Homo sapiens (Human) TR27564_c0_g1_i2 P07439 LEC3_MEGRO 7.00E-11 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Lectin BRA-3 Megabalanus rosa (Acorn barnacle) TR27566_c0_g1_i1 Q8IR79 LIMK1_DROME 7.00E-11 GO:0005524; GO:0030036; GO:0005826; GO:0032154; GO:0048749; GO:0001737; GO:0030496; GO:0048812; GO:0004674; GO:0050770; GO:0051124; GO:0008270 ATP binding; actin cytoskeleton organization; actomyosin contractile ring; cleavage furrow; compound eye development; establishment of imaginal disc-derived wing hair orientation; midbody; neuron projection morphogenesis; protein serine/threonine kinase activity; regulation of axonogenesis; synaptic growth at neuromuscular junction; zinc ion binding IPR011009; IPR001478; IPR000719; IPR017441; IPR001781; LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1) (dLIMK) LIMK1 LIMK CG1848 Drosophila melanogaster (Fruit fly) TR27566_c0_g2_i1 Q54PX0 Y4251_DICDI 6.00E-28 GO:0005524; GO:0046872; GO:0004674 ATP binding; metal ion binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR001245; IPR002290; IPR008271; Probable serine/threonine-protein kinase DDB_G0284251 (EC 2.7.11.1) DDB_G0284251 Dictyostelium discoideum (Slime mold) TR27566_c0_g3_i2 Q99558 M3K14_HUMAN 4.00E-18 GO:0005524; GO:0007249; GO:0004709; GO:0000165; GO:0004704; GO:0031295; GO:0000186; GO:0071260; GO:0005829; GO:0006955; GO:0005634; GO:0043123 P05186; O15111; Q60680-2; O14920 ATP binding; I-kappaB kinase/NF-kappaB cascade; MAP kinase kinase kinase activity; MAPK cascade; NF-kappaB-inducing kinase activity; T cell costimulation; activation of MAPKK activity; cellular response to mechanical stimulus; cytosol; immune response; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade IPR011009; IPR017425; IPR000719; IPR017441; IPR008271; Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK) MAP3K14 NIK Homo sapiens (Human) TR27569_c1_g1_i1 O43301 HS12A_HUMAN 9.00E-18 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR27572_c2_g1_i1 O75093 SLIT1_HUMAN 4.00E-07 GO:0048846; GO:0005509; GO:0005737; GO:0033563; GO:0040023; GO:0005615; GO:0048853; GO:0008045; GO:0050919; GO:0048843; GO:0051964; GO:0031290; GO:0021510; GO:0022028 axon extension involved in axon guidance; calcium ion binding; cytoplasm; dorsal/ventral axon guidance; establishment of nucleus localization; extracellular space; forebrain morphogenesis; motor neuron axon guidance; negative chemotaxis; negative regulation of axon extension involved in axon guidance; negative regulation of synapse assembly; retinal ganglion cell axon guidance; spinal cord development; tangential migration from the subventricular zone to the olfactory bulb IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR009030; IPR001791; IPR001611; IPR025875; IPR003591; IPR000372; Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4) SLIT1 KIAA0813 MEGF4 SLIL1 Homo sapiens (Human) TR27580_c0_g1_i1 Q8VZ19 RL302_ARATH 6.00E-53 GO:0022625; GO:0003735; GO:0006412 cytosolic large ribosomal subunit; structural constituent of ribosome; translation IPR000231; IPR022991; IPR004038; 60S ribosomal protein L30-2 RPL30B At1g77940 F28K19.15 Arabidopsis thaliana (Mouse-ear cress) TR27580_c0_g1_i2 P67884 RL30_OPHHA 6.00E-65 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000231; IPR022991; IPR004038; 60S ribosomal protein L30 RPL30 Ophiophagus hannah (King cobra) (Naja hannah) TR27583_c2_g1_i1 Q0VB26 TEX26_MOUSE 3.00E-10 Testis-expressed sequence 26 protein Tex26 Mus musculus (Mouse) TR27586_c0_g1_i1 P0A0I0 FABG_STAAW 9.00E-23 GO:0004316; GO:0051287; GO:0050661; GO:0030497 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NAD binding; NADP binding; fatty acid elongation IPR011284; IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) (Beta-Ketoacyl-acyl carrier protein reductase) (Beta-ketoacyl-ACP reductase) fabG MW1114 Staphylococcus aureus (strain MW2) TR27586_c0_g1_i2 Q4V8F9 HSDL2_RAT 4.00E-50 GO:0016491; GO:0005777; GO:0032934 oxidoreductase activity; peroxisome; sterol binding IPR002198; IPR002347; IPR016040; IPR003033; Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-) Hsdl2 Rattus norvegicus (Rat) TR27589_c0_g1_i1 Q9UST4 IF5A2_SCHPO 2.00E-54 GO:0002182; GO:0002184; GO:0022626; GO:0005634; GO:0008612; GO:0045901; GO:0045905; GO:0043022; GO:0003746; GO:0006452 cytoplasmic translational elongation; cytoplasmic translational termination; cytosolic ribosome; nucleus; peptidyl-lysine modification to hypusine; positive regulation of translational elongation; positive regulation of translational termination; ribosome binding; translation elongation factor activity; translational frameshifting IPR005824; IPR012340; IPR014722; IPR019769; IPR001884; IPR020189; IPR008991; Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) tif51b SPBC336.10c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR27589_c0_g1_i2 Q07460 IF5A2_CHICK 3.00E-64 GO:0005789; GO:0051028; GO:0005643; GO:0008612; GO:0008284; GO:0045901; GO:0045905; GO:0015031; GO:0043022; GO:0003746; GO:0006452 endoplasmic reticulum membrane; mRNA transport; nuclear pore; peptidyl-lysine modification to hypusine; positive regulation of cell proliferation; positive regulation of translational elongation; positive regulation of translational termination; protein transport; ribosome binding; translation elongation factor activity; translational frameshifting IPR012340; IPR014722; IPR019769; IPR001884; IPR020189; IPR008991; Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2) (eIF-4D) EIF5A2 Gallus gallus (Chicken) TR27595_c0_g1_i1 Q8BLJ3 PLCX3_MOUSE 5.00E-87 GO:0016042; GO:0008081; GO:0004871 lipid catabolic process; phosphoric diester hydrolase activity; signal transducer activity IPR017946; IPR000909; PI-PLC X domain-containing protein 3 Plcxd3 Mus musculus (Mouse) TR27597_c0_g1_i1 P80928 MIF_PIG 4.00E-08 GO:0030330; GO:0007569; GO:0008283; GO:0009986; GO:0007166; GO:0042056; GO:0005737; GO:0004167; GO:0005615; GO:0006954; GO:0045087; GO:0043518; GO:0090344; GO:0071157; GO:0032269; GO:0010629; GO:1902166; GO:0002906; GO:0033033; GO:0050178; GO:0030890; GO:0070374; GO:0043406; GO:0090238; GO:2000343; GO:0050715; GO:0048146; GO:0031666; GO:0061081; GO:0033138; GO:0050731; GO:0061078; GO:0010739; GO:0001516; GO:0070207 "DNA damage response, signal transduction by p53 class mediator; cell aging; cell proliferation; cell surface; cell surface receptor signaling pathway; chemoattractant activity; cytoplasm; dopachrome isomerase activity; extracellular space; inflammatory response; innate immune response; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of cell aging; negative regulation of cell cycle arrest; negative regulation of cellular protein metabolic process; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of mature B cell apoptotic process; negative regulation of myeloid cell apoptotic process; phenylpyruvate tautomerase activity; positive regulation of B cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAP kinase activity; positive regulation of arachidonic acid secretion; positive regulation of chemokine (C-X-C motif) ligand 2 production; positive regulation of cytokine secretion; positive regulation of fibroblast proliferation; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of myeloid leukocyte cytokine production involved in immune response; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of prostaglandin secretion involved in immune response; positive regulation of protein kinase A signaling cascade; prostaglandin biosynthetic process; protein homotrimerization" IPR001398; IPR019829; IPR014347; Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) MIF Sus scrofa (Pig) TR27602_c0_g1_i1 Q53H12 AGK_HUMAN 5.00E-76 GO:0005524; GO:0003951; GO:0047620; GO:0046513; GO:0001729; GO:0004143; GO:0046486; GO:0031966; GO:0007205 ATP binding; NAD+ kinase activity; acylglycerol kinase activity; ceramide biosynthetic process; ceramide kinase activity; diacylglycerol kinase activity; glycerolipid metabolic process; mitochondrial membrane; protein kinase C-activating G-protein coupled receptor signaling pathway IPR016064; IPR001206; Lipid metabolism; glycerolipid metabolism. "Acylglycerol kinase, mitochondrial (hAGK) (EC 2.7.1.107) (EC 2.7.1.94) (Multiple substrate lipid kinase) (HsMuLK) (MuLK) (Multi-substrate lipid kinase)" AGK MULK Homo sapiens (Human) TR27607_c1_g1_i1 Q5W5X9 TTC23_HUMAN 1.00E-31 IPR011990; IPR013105; Tetratricopeptide repeat protein 23 (TPR repeat protein 23) (Cervical cancer proto-oncogene 8 protein) (HCC-8) TTC23 HCC8 Homo sapiens (Human) TR27609_c0_g2_i1 Q86QN6 BDEF_BRABE 2.00E-15 GO:0050829; GO:0050830; GO:0050832; GO:0005576; GO:0031640 defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; defense response to fungus; extracellular region; killing of cells of other organism IPR028060; Big defensin (Defensin) Branchiostoma belcheri (Amphioxus) TR27610_c0_g1_i4 Q3UHD1 BAI1_MOUSE 3.00E-06 GO:0004930; GO:0016021; GO:0016525; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; negative regulation of angiogenesis; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR008077; IPR001879; IPR000832; IPR000203; IPR000884; Brain-specific angiogenesis inhibitor 1 Bai1 Mus musculus (Mouse) TR27611_c1_g1_i1 Q96RW7 HMCN1_HUMAN 2.00E-55 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR27611_c1_g1_i2 Q8WXS8 ATS14_HUMAN 3.00E-11 GO:0030574; GO:0030199; GO:0030198; GO:0005576; GO:0004222; GO:0005578; GO:0006508; GO:0008270 collagen catabolic process; collagen fibril organization; extracellular matrix organization; extracellular region; metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAM-TS 14) (ADAM-TS14) (ADAMTS-14) (EC 3.4.24.-) ADAMTS14 Homo sapiens (Human) TR27614_c2_g1_i1 Q95ND5 CASP3_PIG 5.00E-23 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Sus scrofa (Pig) TR27614_c2_g1_i3 O08738 CASP6_MOUSE 5.00E-30 GO:0006915; GO:0004197; GO:0005829; GO:0005634; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytosol; nucleus; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11] Casp6 Mus musculus (Mouse) TR27614_c2_g1_i4 Q8MJC3 CASP3_RABIT 2.00E-26 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Oryctolagus cuniculus (Rabbit) TR27616_c0_g2_i1 Q9R1K7 TBD_MOUSE 2.00E-09 GO:0005525; GO:0003924; GO:0030154; GO:0005814; GO:0005737; GO:0005874; GO:0007017; GO:0007275; GO:0005634; GO:0051258; GO:0007283; GO:0005200 GTP binding; GTPase activity; cell differentiation; centriole; cytoplasm; microtubule; microtubule-based process; multicellular organismal development; nucleus; protein polymerization; spermatogenesis; structural constituent of cytoskeleton IPR002967; IPR008280; IPR000217; IPR023123; IPR017975; IPR003008; Tubulin delta chain (Delta-tubulin) Tubd1 Mus musculus (Mouse) TR27619_c2_g1_i2 Q8BP00 IQCB1_MOUSE 2.00E-14 GO:0005516; GO:0005813; GO:0042384; GO:0005737; GO:0048496; GO:0045494; GO:0032391; GO:0001750 P28658; Q6A078; O89019; Q8CG73 calmodulin binding; centrosome; cilium assembly; cytoplasm; maintenance of organ identity; photoreceptor cell maintenance; photoreceptor connecting cilium; photoreceptor outer segment IPR016024; IPR000048; IPR027417; IQ calmodulin-binding motif-containing protein 1 Iqcb1 Kiaa0036 Mus musculus (Mouse) TR27620_c3_g1_i2 P35803 GPM6B_MOUSE 2.00E-21 GO:0085029; GO:0016021; GO:0045121; GO:2000009; GO:0051612; GO:0001503; GO:0005886; GO:0030501; GO:0015031; GO:0032956; GO:0051893 extracellular matrix assembly; integral to membrane; membrane raft; negative regulation of protein localization to cell surface; negative regulation of serotonin uptake; ossification; plasma membrane; positive regulation of bone mineralization; protein transport; regulation of actin cytoskeleton organization; regulation of focal adhesion assembly IPR001614; IPR018237; Neuronal membrane glycoprotein M6-b (M6b) Gpm6b M6b Mus musculus (Mouse) TR27634_c3_g1_i1 Q9UPZ3 HPS5_HUMAN 9.00E-21 GO:0007596; GO:0005829; GO:0006996; GO:0043473 blood coagulation; cytosol; organelle organization; pigmentation IPR017217; IPR015943; IPR017986; Hermansky-Pudlak syndrome 5 protein (Alpha-integrin-binding protein 63) (Ruby-eye protein 2 homolog) (Ru2) HPS5 AIBP63 KIAA1017 Homo sapiens (Human) TR27636_c0_g1_i2 Q2KI56 CSN7B_BOVIN 2.00E-87 GO:0008180; GO:0010388; GO:0005737 COP9 signalosome; cullin deneddylation; cytoplasm IPR027530; IPR000717; COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) COPS7B Bos taurus (Bovine) TR27638_c0_g1_i2 O44437 SMD3_DROME 6.00E-50 GO:0071013; GO:0007417; GO:0048542; GO:0000398; GO:0007067; GO:0007052; GO:0007517; GO:0030182; GO:0007422; GO:0045495; GO:0045451; GO:0071011; GO:0030532 "catalytic step 2 spliceosome; central nervous system development; lymph gland development; mRNA splicing, via spliceosome; mitosis; mitotic spindle organization; muscle organ development; neuron differentiation; peripheral nervous system development; pole plasm; pole plasm oskar mRNA localization; precatalytic spliceosome; small nuclear ribonucleoprotein complex" IPR027141; IPR010920; IPR001163; IPR006649; Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3) SmD3 guf2 CG8427 Drosophila melanogaster (Fruit fly) TR27639_c1_g3_i1 A4IG42 F115_DANRE 6.00E-45 Protein FAM115 (Protein FAM139A) fam115 fam139a zgc:162193 Danio rerio (Zebrafish) (Brachydanio rerio) TR27643_c1_g1_i1 P42573 CED3_CAEEL 5.00E-07 GO:0030972; GO:0004197; GO:0009792; GO:0016020; GO:0048471; GO:0016540; GO:0042981 Itself; P30429; P30429-2; P41958 cleavage of cytosolic proteins involved in execution phase of apoptosis; cysteine-type endopeptidase activity; embryo development ending in birth or egg hatching; membrane; perinuclear region of cytoplasm; protein autoprocessing; regulation of apoptotic process IPR001315; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Cell death protein 3 (EC 3.4.22.-) [Cleaved into: Cell death protein 3 subunit 1; Cell death protein 3 subunit 2] ced-3 C48D1.2 Caenorhabditis elegans TR27643_c1_g2_i1 Q14790 CASP8_HUMAN 4.00E-10 GO:0031265; GO:0030690; GO:0035666; GO:0006919; GO:0001525; GO:0044297; GO:0006921; GO:0071260; GO:0005813; GO:0097153; GO:0005829; GO:0031264; GO:0097191; GO:0007507; GO:0045087; GO:0097193; GO:0030225; GO:0045121; GO:0005741; GO:0019048; GO:0043124; GO:0001841; GO:0043005; GO:0070423; GO:0005634; GO:0043123; GO:0045651; GO:1900740; GO:0045862; GO:0051291; GO:0051603; GO:2001239; GO:0046677; GO:0032025; GO:0009409; GO:0032355; GO:0045471; GO:0032496; GO:0034612; GO:0097342; GO:0034138; GO:0034142 P51572; Q92851; Q9UKL3; O15519-1; Q13618; Q13158; P25445; P48023; Q13418; Q9UDY8; O60936; P29350; Q13546; O00220 CD95 death-inducing signaling complex; Noc1p-Noc2p complex; TRIF-dependent toll-like receptor signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cell body; cellular component disassembly involved in execution phase of apoptosis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; cytosol; death-inducing signaling complex; extrinsic apoptotic signaling pathway; heart development; innate immune response; intrinsic apoptotic signaling pathway; macrophage differentiation; membrane raft; mitochondrial outer membrane; modulation by virus of host morphology or physiology; negative regulation of I-kappaB kinase/NF-kappaB cascade; neural tube formation; neuron projection; nucleotide-binding oligomerization domain containing signaling pathway; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macrophage differentiation; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of proteolysis; protein heterooligomerization; proteolysis involved in cellular protein catabolic process; regulation of extrinsic apoptotic signaling pathway in absence of ligand; response to antibiotic; response to cobalt ion; response to cold; response to estradiol stimulus; response to ethanol; response to lipopolysaccharide; response to tumor necrosis factor; ripoptosome; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] CASP8 MCH5 Homo sapiens (Human) TR27643_c1_g2_i2 O89110 CASP8_MOUSE 2.00E-11 GO:0030690; GO:0006919; GO:0001525; GO:0071260; GO:0005813; GO:0097153; GO:0031264; GO:0008625; GO:0007507; GO:0097284; GO:0030225; GO:0005739; GO:0043124; GO:0060546; GO:0001841; GO:0043123; GO:2001238; GO:0045651; GO:0045862; GO:0051603; GO:0070243; GO:0034612 P10275; P19091; P25446; Q9D8Y7 Noc1p-Noc2p complex; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; death-inducing signaling complex; extrinsic apoptotic signaling pathway via death domain receptors; heart development; hepatocyte apoptotic process; macrophage differentiation; mitochondrion; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of necroptosis; neural tube formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of macrophage differentiation; positive regulation of proteolysis; proteolysis involved in cellular protein catabolic process; regulation of thymocyte apoptotic process; response to tumor necrosis factor IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] Casp8 Mus musculus (Mouse) TR27645_c1_g1_i2 Q9V439 MED22_DROME 3.00E-60 GO:0001104; GO:0016592; GO:0007067; GO:0006357 RNA polymerase II transcription cofactor activity; mediator complex; mitosis; regulation of transcription from RNA polymerase II promoter IPR009332; Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (dMED24) MED22 Med24 CG3034 Drosophila melanogaster (Fruit fly) TR27654_c1_g1_i2 A8WHP3 SC5A9_DANRE 4.00E-109 GO:0016021; GO:0006814; GO:0055085; GO:0005215 integral to membrane; sodium ion transport; transmembrane transport; transporter activity IPR001734; IPR018212; IPR019900; Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (Solute carrier family 5 member 9) slc5a9 si:dkey-7o6.5 Danio rerio (Zebrafish) (Brachydanio rerio) TR27654_c2_g1_i1 O70247 SC5A6_RAT 4.00E-06 GO:0015878; GO:0031526; GO:0016021; GO:0015887; GO:0008523; GO:0012506 biotin transport; brush border membrane; integral to membrane; pantothenate transmembrane transport; sodium-dependent multivitamin transmembrane transporter activity; vesicle membrane IPR001734; IPR018212; IPR019900; Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (Solute carrier family 5 member 6) Slc5a6 Smvt Rattus norvegicus (Rat) TR27660_c0_g1_i1 P27393 CO4A2_ASCSU 3.00E-121 GO:0005604; GO:0005581; GO:0005201 basement membrane; collagen; extracellular matrix structural constituent IPR016187; IPR008160; IPR001442; Collagen alpha-2(IV) chain Ascaris suum (Pig roundworm) (Ascaris lumbricoides) TR27661_c3_g1_i1 Q1RHT6 Y997_RICBR 2.00E-07 GO:0006541; GO:0016787 glutamine metabolic process; hydrolase activity IPR002110; IPR020683; IPR017926; IPR011697; Putative ankyrin repeat protein RBE_0997 RBE_0997 Rickettsia bellii (strain RML369-C) TR27662_c1_g2_i1 Q9WVT6 CAH14_MOUSE 2.00E-50 GO:0004089; GO:0016021; GO:0046872 carbonate dehydratase activity; integral to membrane; metal ion binding IPR018429; IPR001148; IPR023561; Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV) Ca14 Car14 Catm Mus musculus (Mouse) TR27663_c0_g1_i1 Q6GME2 CK054_XENLA 2.00E-107 GO:0016787; GO:0046872; GO:0005634 hydrolase activity; metal ion binding; nucleus IPR015021; Ester hydrolase C11orf54 homolog (EC 3.1.-.-) Xenopus laevis (African clawed frog) TR27675_c0_g1_i1 O14512 SOCS7_HUMAN 3.00E-51 GO:0017124; GO:0005737; GO:0045444; GO:0008286; GO:0035556; GO:0009968; GO:0005634; GO:0005886; GO:0016567; GO:0040008 Q8IZP0; Q14141 SH3 domain binding; cytoplasm; fat cell differentiation; insulin receptor signaling pathway; intracellular signal transduction; negative regulation of signal transduction; nucleus; plasma membrane; protein ubiquitination; regulation of growth IPR000980; IPR001496; Protein modification; protein ubiquitination. "Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4)" SOCS7 NAP4 SOCS6 Homo sapiens (Human) TR2768_c0_g1_i1 Q8IVG9 HUNIN_HUMAN 1.00E-07 GO:0006915; GO:0006879; GO:0005576; GO:0030595; GO:0005739; GO:0043066; GO:0048471; GO:0048019 apoptotic process; cellular iron ion homeostasis; extracellular region; leukocyte chemotaxis; mitochondrion; negative regulation of apoptotic process; perinuclear region of cytoplasm; receptor antagonist activity IPR028139; Putative humanin peptide MT-RNR2 Homo sapiens (Human) TR27684_c1_g1_i1 Q96BY7 ATG2B_HUMAN 2.00E-87 GO:0006914; GO:0005811; GO:0034045 autophagy; lipid particle; pre-autophagosomal structure membrane IPR026849; IPR026885; IPR015412; IPR026854; Autophagy-related protein 2 homolog B ATG2B C14orf103 Homo sapiens (Human) TR27684_c1_g1_i2 P0CM30 ATG2_CRYNJ 4.00E-26 GO:0032258; GO:0005770; GO:0030242 CVT pathway; late endosome; peroxisome degradation IPR026849; IPR026886; IPR015412; IPR026854; Autophagy-related protein 2 ATG2 CNB00700 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR27684_c2_g1_i1 Q96BY7 ATG2B_HUMAN 3.00E-17 GO:0006914; GO:0005811; GO:0034045 autophagy; lipid particle; pre-autophagosomal structure membrane IPR026849; IPR026885; IPR015412; IPR026854; Autophagy-related protein 2 homolog B ATG2B C14orf103 Homo sapiens (Human) TR27685_c0_g1_i2 Q19417 YSNK_CAEEL 3.00E-07 GO:0016021 integral to membrane IPR008166; UPF0392 protein F13G3.3 F13G3.3 Caenorhabditis elegans TR27687_c11_g1_i1 Q9NRZ9 HELLS_HUMAN 4.00E-30 GO:0005524; GO:0003677; GO:0051301; GO:0005721; GO:0031508; GO:0003682; GO:0004386; GO:0046651; GO:0010216; GO:0006346; GO:0007067; GO:0007275; GO:0043066; GO:0005634; GO:0006351; GO:0001655 O00716 "ATP binding; DNA binding; cell division; centromeric heterochromatin; centromeric heterochromatin assembly; chromatin binding; helicase activity; lymphocyte proliferation; maintenance of DNA methylation; methylation-dependent chromatin silencing; mitosis; multicellular organismal development; negative regulation of apoptotic process; nucleus; transcription, DNA-dependent; urogenital system development" IPR014001; IPR001650; IPR027417; IPR000330; Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) HELLS PASG SMARCA6 Nbla10143 Homo sapiens (Human) TR27687_c5_g1_i1 Q9NRZ9 HELLS_HUMAN 2.00E-66 GO:0005524; GO:0003677; GO:0051301; GO:0005721; GO:0031508; GO:0003682; GO:0004386; GO:0046651; GO:0010216; GO:0006346; GO:0007067; GO:0007275; GO:0043066; GO:0005634; GO:0006351; GO:0001655 O00716 "ATP binding; DNA binding; cell division; centromeric heterochromatin; centromeric heterochromatin assembly; chromatin binding; helicase activity; lymphocyte proliferation; maintenance of DNA methylation; methylation-dependent chromatin silencing; mitosis; multicellular organismal development; negative regulation of apoptotic process; nucleus; transcription, DNA-dependent; urogenital system development" IPR014001; IPR001650; IPR027417; IPR000330; Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) HELLS PASG SMARCA6 Nbla10143 Homo sapiens (Human) TR27687_c5_g2_i1 O60264 SMCA5_HUMAN 2.00E-101 GO:0005524; GO:0016887; GO:0034080; GO:0003677; GO:0006352; GO:0016589; GO:0031213; GO:0003682; GO:0000183; GO:0005677; GO:0000793; GO:0006302; GO:0009790; GO:0004386; GO:0005730; GO:0005654; GO:0016584; GO:0045893; GO:0006357 Q9UIG0; P62805; Q96T23 "ATP binding; ATPase activity; CENP-A containing nucleosome assembly at centromere; DNA binding; DNA-dependent transcription, initiation; NURF complex; RSF complex; chromatin binding; chromatin silencing at rDNA; chromatin silencing complex; condensed chromosome; double-strand break repair; embryo development; helicase activity; nucleolus; nucleoplasm; nucleosome positioning; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter" IPR020838; IPR014001; IPR001650; IPR009057; IPR015194; IPR027417; IPR001005; IPR017884; IPR015195; IPR000330; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) SMARCA5 SNF2H WCRF135 Homo sapiens (Human) TR27687_c7_g1_i2 Q9W539 HR4_DROME 2.00E-14 GO:0071456; GO:0040007; GO:0030518; GO:0004879; GO:0005634; GO:0048638; GO:0043565; GO:0003707; GO:0008270 cellular response to hypoxia; growth; intracellular steroid hormone receptor signaling pathway; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleus; regulation of developmental growth; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Hormone receptor 4 (dHR4) (Nuclear receptor subfamily 6 group A member 2) Hr4 NR6A2 CG43934 Drosophila melanogaster (Fruit fly) TR27688_c2_g1_i1 H2A0M3 AMO_PINMG 2.00E-133 GO:0009308; GO:0005507; GO:0005576; GO:0008131; GO:0048038 amine metabolic process; copper ion binding; extracellular region; primary amine oxidase activity; quinone binding IPR000269; IPR015798; IPR016182; IPR015801; Putative amine oxidase [copper-containing] (EC 1.4.3.-) Pinctada margaritifera (Black-lipped pearl oyster) TR27688_c2_g1_i2 Q43077 AMO_PEA 3.00E-40 GO:0052595; GO:0009308; GO:0052594; GO:0097185; GO:0005507; GO:0052597; GO:0052596; GO:0008131; GO:0048038; GO:0052593 aliphatic-amine oxidase activity; amine metabolic process; aminoacetone:oxygen oxidoreductase(deaminating) activity; cellular response to azide; copper ion binding; diamine oxidase activity; phenethylamine:oxygen oxidoreductase (deaminating) activity; primary amine oxidase activity; quinone binding; tryptamine:oxygen oxidoreductase (deaminating) activity IPR000269; IPR015798; IPR016182; IPR015800; IPR015801; IPR015802; Primary amine oxidase (EC 1.4.3.21) (Amine oxidase [copper-containing]) Pisum sativum (Garden pea) TR27690_c0_g1_i1 Q9ZQA8 PABPX_ARATH 7.00E-23 GO:0003723; GO:0005737; GO:0000166; GO:0005634; GO:0006417 RNA binding; cytoplasm; nucleotide binding; nucleus; regulation of translation IPR012677; IPR006515; IPR002004; IPR000504; Polyadenylate-binding protein 7 (PABP-7) (Poly(A)-binding protein 7) PAB7 At2g36660 F13K3.6 Arabidopsis thaliana (Mouse-ear cress) TR27690_c0_g2_i1 Q9UT83 MUG28_SCHPO 8.00E-09 GO:0003723; GO:0005619; GO:0031321; GO:0005737; GO:0007126; GO:0000166; GO:0005628 RNA binding; ascospore wall; ascospore-type prospore assembly; cytoplasm; meiosis; nucleotide binding; prospore membrane IPR012677; IPR000504; Meiotically up-regulated gene 28 protein mug28 SPAC343.07 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR27690_c2_g1_i1 P04147 PABP_YEAST 1.00E-23 GO:0010494; GO:0006397; GO:0051028; GO:0000166; GO:0005634; GO:0008143; GO:0060211; GO:0006446; GO:0008428; GO:0005840 P39935; P39936 cytoplasmic stress granule; mRNA processing; mRNA transport; nucleotide binding; nucleus; poly(A) RNA binding; regulation of nuclear-transcribed mRNA poly(A) tail shortening; regulation of translational initiation; ribonuclease inhibitor activity; ribosome IPR012677; IPR006515; IPR002004; IPR000504; "Polyadenylate-binding protein, cytoplasmic and nuclear (PABP) (Poly(A)-binding protein) (ARS consensus-binding protein ACBP-67) (Polyadenylate tail-binding protein)" PAB1 YER165W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR27690_c2_g1_i2 Q98SP8 EPABA_XENLA 2.00E-44 GO:0043009; GO:0005737; GO:0006397; GO:0048255; GO:0060212; GO:0000166; GO:0008143; GO:0006412 O73932; A8KBF3 chordate embryonic development; cytoplasm; mRNA processing; mRNA stabilization; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; nucleotide binding; poly(A) RNA binding; translation IPR012677; IPR006515; IPR002004; IPR000504; Embryonic polyadenylate-binding protein A (Embryonic poly(A)-binding protein A) (ePAB-A) (ePABP-A) (XePABP-A) epabp-a epab Xenopus laevis (African clawed frog) TR27691_c2_g2_i1 B1WB06 MET24_XENTR 2.00E-13 GO:0005576; GO:0008168 extracellular region; methyltransferase activity IPR025714; IPR026913; Methyltransferase-like protein 24 (EC 2.1.1.-) mettl24 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR27695_c0_g1_i1 Q8VE97 SRSF4_MOUSE 3.00E-07 GO:0003723; GO:0008380; GO:0006397; GO:0048025; GO:0016607; GO:0000166 "RNA binding; RNA splicing; mRNA processing; negative regulation of mRNA splicing, via spliceosome; nuclear speck; nucleotide binding" IPR012677; IPR000504; "Serine/arginine-rich splicing factor 4 (Splicing factor, arginine/serine-rich 4)" Srsf4 Sfrs4 MNCb-2616 Mus musculus (Mouse) TR27696_c1_g1_i2 A8QMS7 MYD88_TAKRU 2.00E-63 GO:0002755; GO:0005737; GO:0006954; GO:0045087; GO:0043123 MyD88-dependent toll-like receptor signaling pathway; cytoplasm; inflammatory response; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade IPR011029; IPR000488; IPR017281; IPR000157; Myeloid differentiation primary response protein MyD88 myd88 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR27697_c2_g2_i1 Q5XIA2 SZRD1_RAT 6.00E-14 IPR024771; IPR024642; SUZ domain-containing protein 1 Szrd1 Rattus norvegicus (Rat) TR27698_c1_g1_i1 Q9Y5I1 PCDAB_HUMAN 8.00E-47 GO:0005509; GO:0007155; GO:0007156; GO:0005887; GO:0007399 calcium ion binding; cell adhesion; homophilic cell adhesion; integral to plasma membrane; nervous system development IPR002126; IPR015919; IPR020894; IPR013164; Protocadherin alpha-11 (PCDH-alpha-11) PCDHA11 CNRS7 Homo sapiens (Human) TR27698_c2_g1_i1 Q5DRE5 PCDA7_PANTR 1.00E-19 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR013164; Protocadherin alpha-7 (PCDH-alpha-7) PCDHA7 Pan troglodytes (Chimpanzee) TR27698_c2_g1_i2 Q08174 PCDH1_HUMAN 4.00E-31 GO:0005509; GO:0005911; GO:0007267; GO:0007156; GO:0005887; GO:0007399 calcium ion binding; cell-cell junction; cell-cell signaling; homophilic cell adhesion; integral to plasma membrane; nervous system development IPR002126; IPR015919; IPR020894; IPR013164; IPR013585; Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) PCDH1 Homo sapiens (Human) TR27706_c0_g1_i1 P22760 AAAD_HUMAN 5.00E-39 GO:0004091; GO:0019213; GO:0005789; GO:0016021; GO:0010898; GO:0017171; GO:0004806 carboxylesterase activity; deacetylase activity; endoplasmic reticulum membrane; integral to membrane; positive regulation of triglyceride catabolic process; serine hydrolase activity; triglyceride lipase activity IPR013094; IPR017157; IPR002168; Arylacetamide deacetylase (EC 3.1.1.3) AADAC DAC Homo sapiens (Human) TR2771_c0_g1_i1 Q9JI18 LRP1B_MOUSE 8.00E-22 GO:0005509; GO:0016021; GO:0050750; GO:0005041; GO:0016020 Q9WVI9-1; Q80VC8; P69566 calcium ion binding; integral to membrane; low-density lipoprotein particle receptor binding; low-density lipoprotein receptor activity; membrane IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) Lrp1b Lrpdit Mus musculus (Mouse) TR27710_c1_g2_i1 Q99J23 GHDC_MOUSE 1.00E-68 GO:0005783; GO:0005635 endoplasmic reticulum; nuclear envelope IPR004993; GH3 domain-containing protein Ghdc D11lgp1e Lgp1 Mus musculus (Mouse) TR27710_c2_g1_i3 Q9FZ87 GH317_ARATH 6.00E-08 GO:0010252; GO:0005737; GO:0010279; GO:0005634; GO:0009733 auxin homeostasis; cytoplasm; indole-3-acetic acid amido synthetase activity; nucleus; response to auxin stimulus IPR004993; Indole-3-acetic acid-amido synthetase GH3.17 (EC 6.3.2.-) (Auxin-responsive GH3-like protein 17) (AtGH3-17) GH3.17 At1g28130 F13K9.22 F3H9.21 F3H9_19 Arabidopsis thaliana (Mouse-ear cress) TR27716_c1_g1_i2 Q6UY09 CEA20_HUMAN 2.00E-06 GO:0016021 integral to membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Carcinoembryonic antigen-related cell adhesion molecule 20 CEACAM20 UNQ9366/PRO34155 Homo sapiens (Human) TR27718_c2_g1_i2 Q7Z407 CSMD3_HUMAN 2.00E-16 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 3 (CUB and sushi multiple domains protein 3) CSMD3 KIAA1894 Homo sapiens (Human) TR27718_c2_g1_i5 Q923L3 CSMD1_MOUSE 5.00E-18 GO:0016021 integral to membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 1 (CUB and sushi multiple domains protein 1) Csmd1 Mus musculus (Mouse) TR27718_c2_g1_i6 Q8CFG9 C1RB_MOUSE 5.00E-06 GO:0005509; GO:0006958; GO:0005576; GO:0045087; GO:0006508; GO:0004252 "calcium ion binding; complement activation, classical pathway; extracellular region; innate immune response; proteolysis; serine-type endopeptidase activity" IPR000859; IPR001881; IPR013032; IPR000152; IPR018097; IPR024175; IPR001254; IPR018114; IPR001314; IPR000436; IPR009003; Complement C1r-B subcomponent (EC 3.4.21.41) (Complement component 1 subcomponent r-B) [Cleaved into: Complement C1r-B subcomponent heavy chain; Complement C1r-B subcomponent light chain] C1rb C1r Mus musculus (Mouse) TR27718_c2_g1_i7 P98064 MASP1_MOUSE 3.00E-09 GO:0005509; GO:0001867; GO:0005615; GO:0042803; GO:0006508; GO:0004252 "calcium ion binding; complement activation, lectin pathway; extracellular space; protein homodimerization activity; proteolysis; serine-type endopeptidase activity" IPR000859; IPR001881; IPR013032; IPR018097; IPR024175; IPR001254; IPR018114; IPR001314; IPR000436; IPR009003; Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain] Masp1 Crarf Masp3 Mus musculus (Mouse) TR27720_c0_g2_i1 P71359 RECQ_HAEIN 1.00E-27 GO:0005524; GO:0043140; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0009432; GO:0005622 ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA binding; DNA recombination; DNA repair; DNA replication; SOS response; intracellular IPR011545; IPR004589; IPR006293; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR018982; IPR011991; ATP-dependent DNA helicase RecQ (EC 3.6.4.12) recQ HI_0728 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) TR27720_c0_g2_i2 Q5UPX0 YR290_MIMIV 3.00E-17 GO:0005524; GO:0043140; GO:0006310; GO:0006281; GO:0006260; GO:0003676 ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA recombination; DNA repair; DNA replication; nucleic acid binding IPR011545; IPR004589; IPR014001; IPR001650; IPR027417; IPR018982; IPR011991; Putative ATP-dependent RNA helicase R290 (EC 3.6.4.13) MIMI_R290 Acanthamoeba polyphaga mimivirus (APMV) TR27722_c2_g1_i1 Q63415 PCSK6_RAT 6.00E-76 GO:0005794; GO:0005615; GO:0016486; GO:0006508; GO:0004252 Golgi apparatus; extracellular space; peptide hormone processing; proteolysis; serine-type endopeptidase activity IPR000742; IPR006212; IPR008979; IPR009030; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR010909; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4) Pcsk6 Pace4 Rattus norvegicus (Rat) TR27723_c0_g2_i1 P50226 ST1A2_HUMAN 6.00E-17 GO:0050427; GO:0009309; GO:0004062; GO:0006584; GO:0005829; GO:0047894; GO:0018958; GO:0008202; GO:0051923; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; amine biosynthetic process; aryl sulfotransferase activity; catecholamine metabolic process; cytosol; flavonol 3-sulfotransferase activity; phenol-containing compound metabolic process; steroid metabolic process; sulfation; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase 1A2 (ST1A2) (EC 2.8.2.1) (Aryl sulfotransferase 2) (Phenol sulfotransferase 2) (Phenol-sulfating phenol sulfotransferase 2) (P-PST 2) SULT1A2 STP2 Homo sapiens (Human) TR27723_c0_g2_i2 P52840 ST1A1_MOUSE 3.00E-19 GO:0004062; GO:0005737; GO:0000166; GO:0008202; GO:0008146 aryl sulfotransferase activity; cytoplasm; nucleotide binding; steroid metabolic process; sulfotransferase activity IPR027417; IPR000863; Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase) (Phenol sulfotransferase) (Phenol/aryl sulfotransferase) (mSTp1) (ST1A4) (Sulfokinase) Sult1a1 St1a1 Stp Stp1 Mus musculus (Mouse) TR27724_c0_g1_i2 Q9V0D5 MDH_PYRAB 2.00E-60 GO:0030060; GO:0005737; GO:0006099 L-malate dehydrogenase activity; cytoplasm; tricarboxylic acid cycle IPR003767; Malate dehydrogenase (EC 1.1.1.37) mdh PYRAB08550 PAB1791 Pyrococcus abyssi (strain GE5 / Orsay) TR27725_c0_g2_i2 Q84L09 GONS2_ARATH 2.00E-08 GO:0015784; GO:0000139; GO:0008643; GO:0016021 GDP-mannose transport; Golgi membrane; carbohydrate transport; integral to membrane IPR004853; GDP-mannose transporter GONST2 (Protein GOLGI NUCLEOTIDE SUGAR TRANSPORTER 2) GONST2 At1g07290 F22G5.37 Arabidopsis thaliana (Mouse-ear cress) TR27725_c0_g2_i3 Q15B89 S35D2_PIG 1.00E-111 GO:0000139; GO:0008643; GO:0016021 Golgi membrane; carbohydrate transport; integral to membrane IPR004853; UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (Solute carrier family 35 member D2) (Fragment) SLC35D2 Sus scrofa (Pig) TR27727_c1_g1_i1 P37024 HRPB_ECOLI 1.00E-09 GO:0005524; GO:0008026; GO:0003676 ATP binding; ATP-dependent helicase activity; nucleic acid binding IPR011545; IPR007502; IPR014001; IPR001650; IPR027417; IPR010225; IPR013689; ATP-dependent RNA helicase HrpB (EC 3.6.4.13) hrpB yadO b0148 JW0144 Escherichia coli (strain K12) TR27727_c2_g1_i1 Q6P158 DHX57_HUMAN 9.00E-88 GO:0005524; GO:0008026; GO:0046872; GO:0003676 ATP binding; ATP-dependent helicase activity; metal ion binding; nucleic acid binding IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; IPR006575; IPR009060; IPR015940; IPR000571; Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57) DHX57 Homo sapiens (Human) TR27730_c0_g1_i1 Q9UBZ4 APEX2_HUMAN 5.00E-142 GO:0003677; GO:0006310; GO:0006281; GO:0003906; GO:0007049; GO:0004519; GO:0004527; GO:0005743; GO:0090305; GO:0005634; GO:0008270 DNA binding; DNA recombination; DNA repair; DNA-(apurinic or apyrimidinic site) lyase activity; cell cycle; endonuclease activity; exonuclease activity; mitochondrial inner membrane; nucleic acid phosphodiester bond hydrolysis; nucleus; zinc ion binding IPR004808; IPR020847; IPR005135; IPR010666; DNA-(apurinic or apyrimidinic site) lyase 2 (EC 3.1.-.-) (EC 4.2.99.18) (AP endonuclease XTH2) (APEX nuclease 2) (APEX nuclease-like 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2) APEX2 APE2 APEXL2 XTH2 Homo sapiens (Human) TR27732_c0_g1_i1 Q2NKU0 CENPX_BOVIN 8.00E-15 GO:0006281; GO:0071821; GO:0043240; GO:0051301; GO:0000777; GO:0003690; GO:0051382; GO:0007067; GO:0031297; GO:0000712 DNA repair; FANCM-MHF complex; Fanconi anaemia nuclear complex; cell division; condensed chromosome kinetochore; double-stranded DNA binding; kinetochore assembly; mitosis; replication fork processing; resolution of meiotic recombination intermediates IPR018552; Centromere protein X (CENP-X) (FANCM-interacting histone fold protein 2) (Fanconi anemia-associated polypeptide of 10 kDa) (Stimulated by retinoic acid gene 13 protein homolog) STRA13 CENPX FAAP10 MHF2 Bos taurus (Bovine) TR27733_c2_g1_i1 Q5R503 PTCD2_PONAB 4.00E-14 GO:0006397; GO:0005739; GO:0050684 mRNA processing; mitochondrion; regulation of mRNA processing IPR002885; IPR019266; "Pentatricopeptide repeat-containing protein 2, mitochondrial" PTCD2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR27733_c2_g1_i3 A1L2L5 PTCD2_XENLA 1.00E-08 GO:0006397; GO:0005739; GO:0050684 mRNA processing; mitochondrion; regulation of mRNA processing IPR002885; IPR019266; "Pentatricopeptide repeat-containing protein 2, mitochondrial" ptcd2 Xenopus laevis (African clawed frog) TR27735_c0_g1_i1 Q8BTU1 CP080_MOUSE 1.00E-133 GO:0005929 cilium IPR007714; UPF0468 protein C16orf80 homolog (Gene trap locus 3 protein) Gtl3 Mus musculus (Mouse) TR27735_c0_g1_i2 Q8BTU1 CP080_MOUSE 5.00E-112 GO:0005929 cilium IPR007714; UPF0468 protein C16orf80 homolog (Gene trap locus 3 protein) Gtl3 Mus musculus (Mouse) TR27736_c0_g2_i4 O60602 TLR5_HUMAN 1.00E-08 GO:0002755; GO:0071260; GO:0006954; GO:0045087; GO:0016021; GO:0005886; GO:0032757; GO:0034123; GO:0034166; GO:0034146 MyD88-dependent toll-like receptor signaling pathway; cellular response to mechanical stimulus; inflammatory response; innate immune response; integral to membrane; plasma membrane; positive regulation of interleukin-8 production; positive regulation of toll-like receptor signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway IPR000483; IPR001611; IPR003591; IPR000157; Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3) TLR5 TIL3 Homo sapiens (Human) TR27736_c0_g2_i5 Q689D1 TLR2_CANFA 2.00E-15 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Canis familiaris (Dog) (Canis lupus familiaris) TR27746_c0_g1_i1 Q6DGX3 ANR54_DANRE 7.00E-07 GO:0005737; GO:0030496; GO:0005634 cytoplasm; midbody; nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 54 ankrd54 zgc:110569 zgc:92735 Danio rerio (Zebrafish) (Brachydanio rerio) TR27746_c0_g4_i2 Q566C8 ANR54_RAT 2.00E-41 GO:0007049; GO:0005737; GO:0030496; GO:0006913; GO:0005634; GO:0045648; GO:0019887; GO:0010627 cell cycle; cytoplasm; midbody; nucleocytoplasmic transport; nucleus; positive regulation of erythrocyte differentiation; protein kinase regulator activity; regulation of intracellular protein kinase cascade IPR002110; IPR020683; Ankyrin repeat domain-containing protein 54 Ankrd54 Rattus norvegicus (Rat) TR27746_c0_g4_i3 Q9J5H8 V023_FOWPN 5.00E-08 IPR002110; IPR020683; Putative ankyrin repeat protein FPV023 FPV023 Fowlpox virus (strain NVSL) (FPV) TR27748_c0_g1_i2 Q4V7T8 ROP1L_XENLA 6.00E-89 IPR003117; Ropporin-1-like protein ropn1l Xenopus laevis (African clawed frog) TR27750_c1_g1_i1 Q9NYT6 ZN226_HUMAN 5.00E-19 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 226 ZNF226 Homo sapiens (Human) TR27755_c0_g1_i2 Q66KU2 SC61G_XENLA 2.00E-25 GO:0015450; GO:0005789; GO:0016021; GO:0045047; GO:0008565 P-P-bond-hydrolysis-driven protein transmembrane transporter activity; endoplasmic reticulum membrane; integral to membrane; protein targeting to ER; protein transporter activity IPR023391; IPR008158; IPR001901; Protein transport protein Sec61 subunit gamma sec61g Xenopus laevis (African clawed frog) TR27756_c0_g1_i2 B1LBL4 RS11_THESQ 6.00E-23 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR001971; IPR019981; IPR018102; 30S ribosomal protein S11 rpsK TRQ2_1368 Thermotoga sp. (strain RQ2) TR27757_c0_g1_i1 Q95ND5 CASP3_PIG 5.00E-13 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Sus scrofa (Pig) TR27758_c0_g3_i1 Q96JA1 LRIG1_HUMAN 1.00E-10 GO:0016021 integral to membrane IPR000483; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) LRIG1 LIG1 Homo sapiens (Human) TR27758_c0_g3_i2 O08852 PKD1_MOUSE 1.00E-07 GO:0007259; GO:0016323; GO:0048754; GO:0005262; GO:0030246; GO:0001502; GO:0007050; GO:0005737; GO:0042994; GO:0050982; GO:0048565; GO:0001892; GO:0048806; GO:0007507; GO:0016021; GO:0001822; GO:0001889; GO:0060428; GO:0072177; GO:0072218; GO:0072205; GO:0072287; GO:0072237; GO:0031512; GO:0021915; GO:0007218; GO:0006807; GO:0005634; GO:0018105; GO:0060674; GO:0005886; GO:0002133; GO:0031659; GO:0032092; GO:0045944; GO:0006611; GO:0060236; GO:0043588; GO:0021510 JAK-STAT cascade; basolateral plasma membrane; branching morphogenesis of an epithelial tube; calcium channel activity; carbohydrate binding; cartilage condensation; cell cycle arrest; cytoplasm; cytoplasmic sequestering of transcription factor; detection of mechanical stimulus; digestive tract development; embryonic placenta development; genitalia development; heart development; integral to membrane; kidney development; liver development; lung epithelium development; mesonephric duct development; metanephric ascending thin limb development; metanephric collecting duct development; metanephric distal tubule morphogenesis; metanephric proximal tubule development; motile primary cilium; neural tube development; neuropeptide signaling pathway; nitrogen compound metabolic process; nucleus; peptidyl-serine phosphorylation; placenta blood vessel development; plasma membrane; polycystin complex; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of protein binding; positive regulation of transcription from RNA polymerase II promoter; protein export from nucleus; regulation of mitotic spindle organization; skin development; spinal cord development IPR001304; IPR016186; IPR016187; IPR000483; IPR000203; IPR001611; IPR003591; IPR008976; IPR000372; IPR022409; IPR002859; IPR013122; IPR000434; IPR000601; IPR001024; IPR006228; IPR014010; IPR002889; IPR013994; Polycystin-1 (Autosomal dominant polycystic kidney disease 1 protein homolog) Pkd1 Mus musculus (Mouse) TR27759_c1_g3_i1 Q66HC7 FA48A_RAT 3.00E-57 GO:0000124; GO:0007369; GO:0003712 SAGA complex; gastrulation; transcription cofactor activity IPR021950; Transcription factor SPT20 homolog Supt20h Fam48a Supt20 Rattus norvegicus (Rat) TR27762_c2_g1_i5 Q9HDX8 ALO_SCHPO 4.00E-06 GO:0003885; GO:0008762; GO:0009058; GO:0034599; GO:0050660; GO:0031307 "D-arabinono-1,4-lactone oxidase activity; UDP-N-acetylmuramate dehydrogenase activity; biosynthetic process; cellular response to oxidative stress; flavin adenine dinucleotide binding; integral to mitochondrial outer membrane" IPR007173; IPR016169; IPR016166; IPR016167; IPR010031; IPR023595; IPR006094; "Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2." "D-arabinono-1,4-lactone oxidase (ALO) (EC 1.1.3.37) (L-galactono-gamma-lactone oxidase)" alo1 SPAPB1A10.12c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR27763_c7_g1_i1 Q8WZ42 TITIN_HUMAN 7.00E-17 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR27763_c8_g1_i1 Q26474 LACH_SCHAM 4.00E-08 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Lachesin LAC Schistocerca americana (American grasshopper) TR27765_c1_g1_i1 Q4QQU7 GRTP1_RAT 2.00E-11 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; Growth hormone-regulated TBC protein 1 Grtp1 Rattus norvegicus (Rat) TR27765_c5_g1_i1 Q4KMP7 TB10B_HUMAN 3.00E-82 GO:0005097; GO:0005737 Rab GTPase activator activity; cytoplasm IPR000195; TBC1 domain family member 10B (Rab27A-GAP-beta) TBC1D10B FP2461 Homo sapiens (Human) TR27769_c1_g1_i1 O43900 PRIC3_HUMAN 8.00E-62 GO:0008270 P00519; P06241 zinc ion binding IPR010442; IPR001781; Prickle-like protein 3 (LIM domain only protein 6) (LMO-6) (Triple LIM domain protein 6) PRICKLE3 LMO6 Homo sapiens (Human) TR27769_c1_g1_i2 Q90YH9 TES_CHICK 7.00E-78 GO:0005737; GO:0005925; GO:0008285; GO:0043234; GO:0008270 cytoplasm; focal adhesion; negative regulation of cell proliferation; protein complex; zinc ion binding IPR010442; IPR027683; IPR001781; Testin TES Gallus gallus (Chicken) TR27771_c1_g1_i2 Q8BWR4 UBP40_MOUSE 3.00E-51 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.4.19.12) (Deubiquitinating enzyme 40) (Ubiquitin thioesterase 40) (Ubiquitin-specific-processing protease 40) Usp40 Mus musculus (Mouse) TR27773_c2_g3_i1 Q9UMZ2 SYNRG_HUMAN 8.00E-15 GO:0030121; GO:0005509; GO:0006897; GO:0006886 AP-1 adaptor complex; calcium ion binding; endocytosis; intracellular protein transport IPR011992; IPR000261; Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) SYNRG AP1GBP1 SYNG Homo sapiens (Human) TR27775_c0_g1_i1 Q9Y2V2 CHSP1_HUMAN 2.00E-41 GO:0003677; GO:0043186; GO:0000932; GO:0005829; GO:0035556; GO:0003730; GO:0019902; GO:0043488; GO:0006355 "DNA binding; P granule; cytoplasmic mRNA processing body; cytosol; intracellular signal transduction; mRNA 3'-UTR binding; phosphatase binding; regulation of mRNA stability; regulation of transcription, DNA-dependent" IPR019844; IPR011129; IPR002059; IPR012340; Calcium-regulated heat stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) CARHSP1 Homo sapiens (Human) TR27778_c0_g1_i2 Q8NBQ7 AQP11_HUMAN 6.00E-13 GO:0009986; GO:0005829; GO:0030425; GO:0005783; GO:0048388; GO:0016021; GO:0005886; GO:0051260; GO:0072014; GO:0055085; GO:0005215; GO:0006833 cell surface; cytosol; dendrite; endoplasmic reticulum; endosomal lumen acidification; integral to membrane; plasma membrane; protein homooligomerization; proximal tubule development; transmembrane transport; transporter activity; water transport IPR023271; IPR023266; IPR016697; IPR000425; Aquaporin-11 (AQP-11) AQP11 AQPX1 PSEC0027 Homo sapiens (Human) TR27778_c0_g1_i4 Q8NBQ7 AQP11_HUMAN 1.00E-12 GO:0009986; GO:0005829; GO:0030425; GO:0005783; GO:0048388; GO:0016021; GO:0005886; GO:0051260; GO:0072014; GO:0055085; GO:0005215; GO:0006833 cell surface; cytosol; dendrite; endoplasmic reticulum; endosomal lumen acidification; integral to membrane; plasma membrane; protein homooligomerization; proximal tubule development; transmembrane transport; transporter activity; water transport IPR023271; IPR023266; IPR016697; IPR000425; Aquaporin-11 (AQP-11) AQP11 AQPX1 PSEC0027 Homo sapiens (Human) TR27781_c0_g2_i1 Q9NQT4 EXOS5_HUMAN 6.00E-38 GO:0000175; GO:0045006; GO:0003723; GO:0005829; GO:0051607; GO:0043928; GO:0000178; GO:0005730; GO:0006364; GO:0035327 Q9Y3B2; Q9NQT5; Q96B26 3'-5'-exoribonuclease activity; DNA deamination; RNA binding; cytosol; defense response to virus; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; exosome (RNase complex); nucleolus; rRNA processing; transcriptionally active chromatin IPR001247; IPR015847; IPR027408; IPR020568; Exosome complex component RRP46 (Chronic myelogenous leukemia tumor antigen 28) (Exosome component 5) (Ribosomal RNA-processing protein 46) (p12B) EXOSC5 CML28 RRP46 Homo sapiens (Human) TR27781_c0_g3_i1 Q9NPD3 EXOS4_HUMAN 4.00E-14 GO:0000175; GO:0017091; GO:0045006; GO:0005829; GO:0051607; GO:0043928; GO:0000178; GO:0071044; GO:0000460; GO:0071028; GO:0005730; GO:0030307; GO:0035327 Q9Y3B2; Q01780; Q13868; Q9NQT5; Q06265 3'-5'-exoribonuclease activity; AU-rich element binding; DNA deamination; cytosol; defense response to virus; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; exosome (RNase complex); histone mRNA catabolic process; maturation of 5.8S rRNA; nuclear mRNA surveillance; nucleolus; positive regulation of cell growth; transcriptionally active chromatin IPR001247; IPR015847; IPR027408; IPR020568; Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A) EXOSC4 RRP41 SKI6 Homo sapiens (Human) TR27783_c0_g1_i1 Q9GZQ3 COMD5_HUMAN 1.00E-61 GO:0005634 nucleus IPR017920; IPR009886; COMM domain-containing protein 5 (Hypertension-related calcium-regulated gene protein) (HCaRG) COMMD5 HT002 Homo sapiens (Human) TR27786_c1_g1_i1 A2AX52 CO6A4_MOUSE 8.00E-16 GO:0007155; GO:0005581; GO:0005576; GO:0043234; GO:0070208 cell adhesion; collagen; extracellular region; protein complex; protein heterotrimerization IPR008160; IPR002035; Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) TR27788_c0_g2_i1 P86860 PSM_MYTCA 6.00E-17 GO:0005576 extracellular region IPR008985; IPR013320; Shell matrix protein (Fragment) Mytilus californianus (California mussel) TR27791_c0_g1_i1 Q00776 AP1M1_YEAST 2.00E-27 GO:0030121; GO:0006896; GO:0030276; GO:0005905; GO:0006886 P36000; P35181 AP-1 adaptor complex; Golgi to vacuole transport; clathrin binding; coated pit; intracellular protein transport IPR022775; IPR001392; IPR008968; IPR018240; IPR011012; AP-1 complex subunit mu-1-I (Clathrin assembly protein complex 1 mu-1-I medium chain) (Clathrin coat assembly protein AP54) (Clathrin coat-associated protein AP54) (Golgi adaptor AP-1 54 kDa protein) (HA1 54 kDa subunit) (Mu(1)-adaptin) (Mu1-I-adaptin) APM1 YAP54 YPL259C P0394 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR27791_c0_g1_i2 Q29RY8 AP4M1_BOVIN 2.00E-71 GO:0005794; GO:0006895; GO:0030131; GO:0005905; GO:0006886; GO:0005802 Golgi apparatus; Golgi to endosome transport; clathrin adaptor complex; coated pit; intracellular protein transport; trans-Golgi network IPR022775; IPR001392; IPR008968; IPR018240; IPR011012; AP-4 complex subunit mu-1 (AP-4 adapter complex mu subunit) (Adapter-related protein complex 4 subunit mu-1) (Mu subunit of AP-4) (Mu-adaptin-related protein 2) (mu-ARP2) (Mu4-adaptin) (mu4) AP4M1 Bos taurus (Bovine) TR27791_c0_g1_i5 Q9GPF0 AP4M_DICDI 6.00E-30 GO:0030124; GO:0030131; GO:0030659; GO:0006886; GO:0016192 AP-4 adaptor complex; clathrin adaptor complex; cytoplasmic vesicle membrane; intracellular protein transport; vesicle-mediated transport IPR022775; IPR001392; IPR008968; IPR011012; AP-4 complex subunit mu (AP-4 adapter complex mu4 subunit) (Adapter-related protein complex 4 subunit mu) (Clathrin-adaptor medium chain Apm4) (Mu4-adaptin) apm4 DDB_G0276945 Dictyostelium discoideum (Slime mold) TR27794_c0_g1_i1 Q9JLJ0 LITAF_MOUSE 1.00E-19 GO:0005794; GO:0050699; GO:0006915; GO:0071222; GO:0005765; GO:0042347; GO:0005886; GO:0043123; GO:0001817; GO:0006355; GO:0004871; GO:0006351 P46935 "Golgi apparatus; WW domain binding; apoptotic process; cellular response to lipopolysaccharide; lysosomal membrane; negative regulation of NF-kappaB import into nucleus; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of cytokine production; regulation of transcription, DNA-dependent; signal transducer activity; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Estrogen-enhanced transcript protein) (mEET) (LITAF-like protein) (NEDD4 WW domain-binding protein 3) Litaf N4wbp3 Tbx1 Mus musculus (Mouse) TR27794_c0_g1_i4 Q6GMG8 LITAF_DANRE 3.00E-17 GO:0005737; GO:0006355; GO:0006351 "cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) litaf zgc:91882 Danio rerio (Zebrafish) (Brachydanio rerio) TR27796_c0_g1_i1 P06400 RB_HUMAN 1.00E-41 GO:0016605; GO:0007265; GO:0035189; GO:0016514; GO:0050681; GO:0030521; GO:0007050; GO:0051301; GO:0048667; GO:0000785; GO:0006338; GO:0001047; GO:0048565; GO:0043353; GO:0019900; GO:0034088; GO:0007093; GO:0019048; GO:0045445; GO:2000134; GO:0050680; GO:0006469; GO:0043433; GO:0045879; GO:0007070; GO:0071930; GO:0051402; GO:0042551; GO:0031175; GO:0045651; GO:0045842; GO:0045944; GO:0045893; GO:0071459; GO:0090230; GO:0071922; GO:0043550; GO:0000083; GO:0003700; GO:0031134; GO:0035914; GO:0005819; GO:0051146; GO:0003713; GO:0006351 Itself; P03070; P03255; P03255-1; P03255-2; P24941; P30285; Q155P7; O14757; O96017; Q13574-2; Q13627; Q9Y463; Q01094; Q14209; O00716; A0MPS7; P03129; P04020; P06464; P06465; P06788; P42685; O60381; Q13547; P52927; Q9R002; Q14653; Q16539; Q00987; O15151; Q14686; P07197; Q8VSP9; Q9UQ80; P62136; P55345; Q00577; P04049; O75150; Q8WTS6; Q923E4; Q3TKT4; Q96PU4 "PML body; Ras protein signal transduction; Rb-E2F complex; SWI/SNF complex; androgen receptor binding; androgen receptor signaling pathway; cell cycle arrest; cell division; cell morphogenesis involved in neuron differentiation; chromatin; chromatin remodeling; core promoter binding; digestive tract development; enucleate erythrocyte differentiation; kinase binding; maintenance of mitotic sister chromatid cohesion; mitotic cell cycle checkpoint; modulation by virus of host morphology or physiology; myoblast differentiation; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of epithelial cell proliferation; negative regulation of protein kinase activity; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of smoothened signaling pathway; negative regulation of transcription from RNA polymerase II promoter during mitosis; negative regulation of transcription involved in G1/S transition of mitotic cell cycle; neuron apoptotic process; neuron maturation; neuron projection development; positive regulation of macrophage differentiation; positive regulation of mitotic metaphase/anaphase transition; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein localization to chromosome, centromeric region; regulation of centromere complex assembly; regulation of cohesin localization to chromatin; regulation of lipid kinase activity; regulation of transcription involved in G1/S transition of mitotic cell cycle; sequence-specific DNA binding transcription factor activity; sister chromatid biorientation; skeletal muscle cell differentiation; spindle; striated muscle cell differentiation; transcription coactivator activity; transcription, DNA-dependent" IPR013763; IPR015652; IPR002720; IPR002719; IPR015030; IPR028309; IPR024599; Retinoblastoma-associated protein (p105-Rb) (pRb) (Rb) (pp110) RB1 Homo sapiens (Human) TR27796_c0_g2_i1 O55081 RBL2_RAT 3.00E-22 GO:0003677; GO:0007049; GO:0000785; GO:0016568; GO:0005634; GO:0051726; GO:0006357; GO:0005667; GO:0006351 "DNA binding; cell cycle; chromatin; chromatin modification; nucleus; regulation of cell cycle; regulation of transcription from RNA polymerase II promoter; transcription factor complex; transcription, DNA-dependent" IPR013763; IPR028308; IPR002720; IPR002719; IPR028309; IPR024599; Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (PPAR-alpha-interacting complex protein 128) (PRIC128) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) Rbl2 Rattus norvegicus (Rat) TR27799_c2_g1_i1 Q8WZ42 TITIN_HUMAN 9.00E-12 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR27799_c2_g1_i2 P97528 CNTN6_RAT 4.00E-13 GO:0007219; GO:0046658; GO:0007155 Notch signaling pathway; anchored to plasma membrane; cell adhesion IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Contactin-6 (Neural recognition molecule NB-3) Cntn6 Rattus norvegicus (Rat) TR27799_c3_g2_i1 Q61330 CNTN2_MOUSE 1.00E-08 GO:0007628; GO:0031225; GO:0007411; GO:0007413; GO:0030246; GO:0007155; GO:0009986; GO:0022010; GO:0021853; GO:0045163; GO:0071206; GO:0001948; GO:0044224; GO:0007612; GO:0000226; GO:0043209; GO:0045665; GO:0001764; GO:0043025; GO:0033268; GO:0005886; GO:0060168; GO:0010954; GO:0031623; GO:0048710; GO:0031133; GO:0048168 adult walking behavior; anchored to membrane; axon guidance; axonal fasciculation; carbohydrate binding; cell adhesion; cell surface; central nervous system myelination; cerebral cortex GABAergic interneuron migration; clustering of voltage-gated potassium channels; establishment of protein localization to juxtaparanode region of axon; glycoprotein binding; juxtaparanode region of axon; learning; microtubule cytoskeleton organization; myelin sheath; negative regulation of neuron differentiation; neuron migration; neuronal cell body; node of Ranvier; plasma membrane; positive regulation of adenosine receptor signaling pathway; positive regulation of protein processing; receptor internalization; regulation of astrocyte differentiation; regulation of axon diameter; regulation of neuronal synaptic plasticity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Contactin-2 (Axonal glycoprotein TAG-1) (Axonin-1) (Transient axonal glycoprotein 1) (TAX-1) Cntn2 Tax Mus musculus (Mouse) TR27799_c3_g2_i2 Q9UPX0 TUTLB_HUMAN 8.00E-08 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Protein turtle homolog B (Immunoglobulin superfamily member 9B) (IgSF9B) IGSF9B KIAA1030 Homo sapiens (Human) TR27799_c4_g4_i1 Q96RW7 HMCN1_HUMAN 2.00E-20 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR27799_c4_g4_i2 Q9Y624 JAM1_HUMAN 4.00E-06 GO:0007596; GO:0007155; GO:0005911; GO:0030855; GO:0006954; GO:0016021; GO:0050900; GO:0019048; GO:0005886; GO:0005923; GO:0070830; GO:0007179 Q8TEW0 blood coagulation; cell adhesion; cell-cell junction; epithelial cell differentiation; inflammatory response; integral to membrane; leukocyte migration; modulation by virus of host morphology or physiology; plasma membrane; tight junction; tight junction assembly; transforming growth factor beta receptor signaling pathway IPR007110; IPR013783; IPR003598; IPR013106; IPR003596; Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet F11 receptor) (Platelet adhesion molecule 1) (PAM-1) (CD antigen CD321) F11R JAM1 JCAM UNQ264/PRO301 Homo sapiens (Human) TR27799_c4_g4_i3 Q6MZW2 FSTL4_HUMAN 2.00E-09 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR011992; IPR018247; IPR002048; IPR007110; IPR013783; IPR013098; IPR003598; IPR002350; IPR015943; Follistatin-related protein 4 (Follistatin-like protein 4) FSTL4 KIAA1061 Homo sapiens (Human) TR27799_c5_g1_i1 A2ASS6 TITIN_MOUSE 3.00E-18 GO:0005524; GO:0031430; GO:0030018; GO:0007512; GO:0055003; GO:0043056; GO:0003007; GO:0001701; GO:0046872; GO:0006936; GO:0005859; GO:0005634; GO:0018108; GO:0004674; GO:0004713; GO:1901897; GO:0045214; GO:0001756; GO:0005200 ATP binding; M band; Z disc; adult heart development; cardiac myofibril assembly; forward locomotion; heart morphogenesis; in utero embryonic development; metal ion binding; muscle contraction; muscle myosin complex; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of relaxation of cardiac muscle; sarcomere organization; somitogenesis; structural constituent of cytoskeleton IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) TR27799_c5_g1_i2 Q90478 L1CA1_DANRE 7.00E-14 GO:0007155; GO:0030154; GO:0016021; GO:0007399; GO:0005886 cell adhesion; cell differentiation; integral to membrane; nervous system development; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR026966; Neural cell adhesion molecule L1.1 (N-CAM-L1.1) (NCAM-L1.1) (Fragment) nadl1.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR27799_c5_g2_i1 Q32MD9 CDON_MOUSE 3.00E-06 GO:0009952; GO:0001708; GO:0009986; GO:0016337; GO:0021987; GO:0010172; GO:0060059; GO:0005887; GO:0002088; GO:0007520; GO:0043410; GO:0045663; GO:2000179; GO:0045666; GO:0001934; GO:0048643; GO:0051057; GO:0045944; GO:0043497; GO:0014816; GO:0007224 P00520 anterior/posterior pattern specification; cell fate specification; cell surface; cell-cell adhesion; cerebral cortex development; embryonic body morphogenesis; embryonic retina morphogenesis in camera-type eye; integral to plasma membrane; lens development in camera-type eye; myoblast fusion; positive regulation of MAPK cascade; positive regulation of myoblast differentiation; positive regulation of neural precursor cell proliferation; positive regulation of neuron differentiation; positive regulation of protein phosphorylation; positive regulation of skeletal muscle tissue development; positive regulation of small GTPase mediated signal transduction; positive regulation of transcription from RNA polymerase II promoter; regulation of protein heterodimerization activity; satellite cell differentiation; smoothened signaling pathway IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Cell adhesion molecule-related/down-regulated by oncogenes Cdon Cdo Mus musculus (Mouse) TR27799_c5_g2_i2 Q8N6G6 ATL1_HUMAN 2.00E-07 GO:0008237; GO:0005578; GO:0008270 metallopeptidase activity; proteinaceous extracellular matrix; zinc ion binding IPR007110; IPR013783; IPR013098; IPR003598; IPR013273; IPR010909; IPR000884; ADAMTS-like protein 1 (ADAMTSL-1) (Punctin-1) ADAMTSL1 ADAMTSR1 C9orf94 UNQ528/PRO1071 Homo sapiens (Human) TR278_c0_g1_i1 B0W6M9 SUR8_CULQU 1.00E-08 GO:0046579; GO:0000164 positive regulation of Ras protein signal transduction; protein phosphatase type 1 complex IPR001611; IPR025875; IPR003591; IPR027036; Leucine-rich repeat protein soc-2 homolog (Protein Sur-8 homolog) (Protein soc-2 homolog) Sur-8 CPIJ002780 Culex quinquefasciatus (Southern house mosquito) (Culex pungens) TR27800_c1_g1_i1 P64264 Y1310_MYCBO 4.00E-19 GO:0006066; GO:0008812; GO:0050660 alcohol metabolic process; choline dehydrogenase activity; flavin adenine dinucleotide binding IPR012132; IPR000172; IPR007867; Uncharacterized GMC-type oxidoreductase Mb1310 (EC 1.1.-.-) Mb1310 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) TR27802_c0_g1_i1 Q9I993 BCDO1_CHICK 4.00E-11 GO:0003834; GO:0046872; GO:0004497; GO:0001523; GO:0042572 "beta-carotene 15,15'-monooxygenase activity; metal ion binding; monooxygenase activity; retinoid metabolic process; retinol metabolic process" IPR004294; Cofactor metabolism; retinol metabolism. "Beta,beta-carotene 15,15'-monooxygenase (EC 1.14.99.36) (Beta-carotene dioxygenase 1)" BCMO1 BCDO Gallus gallus (Chicken) TR27802_c0_g1_i2 Q9YGX2 RPE65_CHICK 8.00E-22 GO:0052885; GO:0052884; GO:0005783; GO:0016853; GO:0046872; GO:0031090; GO:0005886; GO:0050896; GO:0042572; GO:0007601 "all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity; all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity; endoplasmic reticulum; isomerase activity; metal ion binding; organelle membrane; plasma membrane; response to stimulus; retinol metabolic process; visual perception" IPR004294; Retinoid isomerohydrolase (EC 3.1.1.64) (All-trans-retinyl-palmitate hydrolase) (Retinal pigment epithelium-specific 65 kDa protein) (Retinol isomerase) RPE65 Gallus gallus (Chicken) TR27804_c2_g1_i1 Q9W4E2 NBEA_DROME 2.00E-134 GO:0042675; GO:0005737; GO:0042462; GO:0016021; GO:0016319; GO:0007528; GO:0043025; GO:0008355; GO:0051018 compound eye cone cell differentiation; cytoplasm; eye photoreceptor cell development; integral to membrane; mushroom body development; neuromuscular junction development; neuronal cell body; olfactory learning; protein kinase A binding IPR016024; IPR000409; IPR008985; IPR013320; IPR010508; IPR023362; IPR015943; IPR001680; IPR017986; Neurobeachin (A-kinase anchor protein 550) (AKAP 550) (Protein rugose) (dAKAP550) rg Akap550 CG6775 Drosophila melanogaster (Fruit fly) TR27804_c2_g1_i2 Q9ESE1 LRBA_MOUSE 4.00E-112 GO:0005794; GO:0016023; GO:0005783; GO:0016197; GO:0016021; GO:0005764; GO:0005886; GO:0051018; GO:0008104; GO:0007165; GO:0005802 Golgi apparatus; cytoplasmic membrane-bounded vesicle; endoplasmic reticulum; endosomal transport; integral to membrane; lysosome; plasma membrane; protein kinase A binding; protein localization; signal transduction; trans-Golgi network IPR011989; IPR016024; IPR000409; IPR008985; IPR013320; IPR010508; IPR023362; IPR015943; IPR001680; IPR017986; Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) Lrba Bgl Lba Mus musculus (Mouse) TR27806_c3_g1_i1 Q7Z7A1 CNTRL_HUMAN 2.00E-19 GO:0000086; GO:0051301; GO:0005813; GO:0005829 G2/M transition of mitotic cell cycle; cell division; centrosome; cytosol IPR001611; Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110) CNTRL CEP1 CEP110 Homo sapiens (Human) TR27809_c0_g2_i1 O07137 ECHA8_MYCLE 4.00E-08 GO:0004300; GO:0006631 enoyl-CoA hydratase activity; fatty acid metabolic process IPR001753; IPR018376; Probable enoyl-CoA hydratase echA8 (EC 4.2.1.17) echA8 ML2402 MLCB1306.05c Mycobacterium leprae (strain TN) TR27809_c0_g2_i2 A5F465 FADB_VIBC3 1.00E-11 GO:0003857; GO:0008692; GO:0050662; GO:0004165; GO:0004300; GO:0006635 3-hydroxyacyl-CoA dehydrogenase activity; 3-hydroxybutyryl-CoA epimerase activity; coenzyme binding; dodecenoyl-CoA delta-isomerase activity; enoyl-CoA hydratase activity; fatty acid beta-oxidation IPR006180; IPR006176; IPR006108; IPR008927; IPR001753; IPR013328; IPR012799; IPR016040; Lipid metabolism; fatty acid beta-oxidation. Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase (EC 4.2.1.17) (EC 5.1.2.3) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)] fadB VC0395_A2534 VC395_0197 Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) TR27809_c0_g2_i3 A7MQP0 FADB_CROS8 2.00E-13 GO:0003857; GO:0008692; GO:0050662; GO:0004165; GO:0004300; GO:0006635 3-hydroxyacyl-CoA dehydrogenase activity; 3-hydroxybutyryl-CoA epimerase activity; coenzyme binding; dodecenoyl-CoA delta-isomerase activity; enoyl-CoA hydratase activity; fatty acid beta-oxidation IPR006180; IPR006176; IPR006108; IPR008927; IPR001753; IPR013328; IPR012799; IPR016040; Lipid metabolism; fatty acid beta-oxidation. Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase (EC 4.2.1.17) (EC 5.1.2.3) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)] fadB ESA_03714 Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii) TR27811_c1_g1_i1 P28824 NRP1_XENLA 2.00E-09 GO:0001525; GO:0007411; GO:0007155; GO:0035767; GO:0008201; GO:0016021; GO:0046872; GO:0009887; GO:0017154; GO:0048010; GO:0005021 angiogenesis; axon guidance; cell adhesion; endothelial cell chemotaxis; heparin binding; integral to membrane; metal ion binding; organ morphogenesis; semaphorin receptor activity; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor-activated receptor activity IPR000421; IPR008985; IPR000859; IPR008979; IPR000998; IPR014648; IPR022579; IPR027146; Neuropilin-1 (A5 antigen) (A5 protein) nrp1 Xenopus laevis (African clawed frog) TR27811_c1_g1_i2 Q5VYJ5 CJ112_HUMAN 1.00E-30 GO:0016021 integral to membrane IPR008985; IPR023415; IPR002172; IPR000998; MAM and LDL-receptor class A domain-containing protein C10orf112 C10orf112 Homo sapiens (Human) TR27814_c1_g2_i1 Q13751 LAMB3_HUMAN 6.00E-07 GO:0050873; GO:0007155; GO:0008544; GO:0030198; GO:0005576; GO:0031581; GO:0005610; GO:0005198 brown fat cell differentiation; cell adhesion; epidermis development; extracellular matrix organization; extracellular region; hemidesmosome assembly; laminin-5 complex; structural molecule activity IPR013032; IPR002049; IPR008211; Laminin subunit beta-3 (Epiligrin subunit bata) (Kalinin B1 chain) (Kalinin subunit beta) (Laminin B1k chain) (Laminin-5 subunit beta) (Nicein subunit beta) LAMB3 LAMNB1 Homo sapiens (Human) TR27814_c1_g2_i4 Q5ND28 SREC_MOUSE 1.00E-21 GO:0007155; GO:0016358; GO:0016021; GO:0030169; GO:0016322; GO:0005886; GO:0048680; GO:0005044 cell adhesion; dendrite development; integral to membrane; low-density lipoprotein particle binding; neuron remodeling; plasma membrane; positive regulation of axon regeneration; scavenger receptor activity IPR000742; IPR013032; IPR002049; IPR009030; Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) TR27814_c1_g2_i6 Q80V70 MEGF6_MOUSE 1.00E-15 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR013111; IPR002049; IPR011489; IPR009030; Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) TR27814_c1_g2_i7 Q06806 TIE1_MOUSE 3.00E-13 GO:0005524; GO:0001525; GO:0001701; GO:0016021; GO:0016525; GO:0030336; GO:0018108; GO:0005886; GO:0045026; GO:0032526; GO:0004714 ATP binding; angiogenesis; in utero embryonic development; integral to membrane; negative regulation of angiogenesis; negative regulation of cell migration; peptidyl-tyrosine phosphorylation; plasma membrane; plasma membrane fusion; response to retinoic acid; transmembrane receptor protein tyrosine kinase activity IPR000742; IPR013032; IPR003961; IPR007110; IPR013783; IPR003599; IPR013151; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) Tie1 Tie Tie-1 Mus musculus (Mouse) TR27822_c0_g1_i4 Q5RJ80 CAPR2_DANRE 9.00E-10 GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:2000055; GO:0090263; GO:0050775; GO:0061003; GO:0040008 RNA binding; cytoplasm; dorsal/ventral pattern formation; negative regulation of translation; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of dendrite morphogenesis; positive regulation of dendritic spine morphogenesis; regulation of growth IPR001073; IPR008983; Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR27823_c0_g1_i1 Q9Y345 SC6A5_HUMAN 6.00E-129 GO:0015375; GO:0016021; GO:0005328; GO:0005886; GO:0007268 glycine:sodium symporter activity; integral to membrane; neurotransmitter:sodium symporter activity; plasma membrane; synaptic transmission IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) TR27826_c1_g2_i1 Q9NR64 KLHL1_HUMAN 4.00E-06 GO:0003779; GO:0030036; GO:0007628; GO:0021680; GO:0005737; GO:0005856; GO:0030425; GO:0016358; GO:0043025 actin binding; actin cytoskeleton organization; adult walking behavior; cerebellar Purkinje cell layer development; cytoplasm; cytoskeleton; dendrite; dendrite development; neuronal cell body IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR006652; Kelch-like protein 1 KLHL1 KIAA1490 Homo sapiens (Human) TR27826_c1_g3_i1 Q70JS2 KELC_ANOST 1.00E-20 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR006652; Ring canal kelch homolog (Kelch-like protein 1) [Cleaved into: Kelch short protein] kel Anopheles stephensi (Indo-Pakistan malaria mosquito) TR27826_c1_g3_i2 Q96KE9 BTBD6_HUMAN 6.00E-36 GO:0000932 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6 (Lens BTB domain protein) BTBD6 BDPL Homo sapiens (Human) TR27826_c1_g3_i3 Q6GR09 SPOPL_XENLA 1.00E-15 GO:0031463; GO:0031397; GO:0005634; GO:0043161; GO:0016567 Cul3-RING ubiquitin ligase complex; negative regulation of protein ubiquitination; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination IPR000210; IPR011333; IPR013069; IPR002083; IPR008974; Protein modification; protein ubiquitination. Speckle-type POZ protein-like spopl Xenopus laevis (African clawed frog) TR27827_c1_g2_i1 Q6IMN6 CAPR2_HUMAN 3.00E-13 GO:0003723; GO:0005739; GO:0030308; GO:0017148; GO:0090263; GO:0050775; GO:0061003; GO:0033138; GO:0032092; GO:0045944; GO:0043235 O75197 RNA binding; mitochondrion; negative regulation of cell growth; negative regulation of translation; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of dendrite morphogenesis; positive regulation of dendritic spine morphogenesis; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of transcription from RNA polymerase II promoter; receptor complex IPR001073; IPR022070; IPR008983; Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (Gastric cancer multidrug resistance-associated protein) (Protein EEG-1) (RNA granule protein 140) CAPRIN2 C1QDC1 EEG1 KIAA1873 RNG140 Homo sapiens (Human) TR27828_c1_g1_i2 Q86IC8 CAMT2_DICDI 2.00E-27 GO:0042409; GO:0046872; GO:0045335; GO:0009617 caffeoyl-CoA O-methyltransferase activity; metal ion binding; phagocytic vesicle; response to bacterium IPR002935; Probable caffeoyl-CoA O-methyltransferase 2 (EC 2.1.1.104) (O-methyltransferase 6) omt6 DDB_G0275501 Dictyostelium discoideum (Slime mold) TR27828_c1_g1_i3 Q86IC8 CAMT2_DICDI 5.00E-15 GO:0042409; GO:0046872; GO:0045335; GO:0009617 caffeoyl-CoA O-methyltransferase activity; metal ion binding; phagocytic vesicle; response to bacterium IPR002935; Probable caffeoyl-CoA O-methyltransferase 2 (EC 2.1.1.104) (O-methyltransferase 6) omt6 DDB_G0275501 Dictyostelium discoideum (Slime mold) TR27829_c0_g1_i2 O43614 OX2R_HUMAN 9.00E-29 GO:0022410; GO:0007631; GO:0005887; GO:0008188; GO:0016499; GO:0017046; GO:0007200 circadian sleep/wake cycle process; feeding behavior; integral to plasma membrane; neuropeptide receptor activity; orexin receptor activity; peptide hormone binding; phospholipase C-activating G-protein coupled receptor signaling pathway IPR000276; IPR017452; IPR000204; IPR004060; Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) HCRTR2 Homo sapiens (Human) TR2783_c0_g1_i1 Q9Y2P5 S27A5_HUMAN 8.00E-16 GO:0005524; GO:0009925; GO:0015721; GO:0006699; GO:0047747; GO:0015245; GO:0030176; GO:0046951; GO:0015911; GO:0043234; GO:0006642; GO:0000038; GO:0031957 ATP binding; basal plasma membrane; bile acid and bile salt transport; bile acid biosynthetic process; cholate-CoA ligase activity; fatty acid transporter activity; integral to endoplasmic reticulum membrane; ketone body biosynthetic process; plasma membrane long-chain fatty acid transport; protein complex; triglyceride mobilization; very long-chain fatty acid metabolic process; very long-chain fatty acid-CoA ligase activity IPR025110; IPR020845; IPR000873; "Bile acyl-CoA synthetase (BACS) (EC 6.2.1.7) (Bile acid-CoA ligase) (BA-CoA ligase) (BAL) (Cholate--CoA ligase) (Fatty acid transport protein 5) (FATP-5) (Fatty-acid-coenzyme A ligase, very long-chain 3) (Solute carrier family 27 member 5) (Very long-chain acyl-CoA synthetase homolog 2) (VLCS-H2) (VLCSH2) (Very long-chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR)" SLC27A5 ACSB ACSVL6 FACVL3 FATP5 Homo sapiens (Human) TR27831_c0_g1_i3 Q9NPC3 CIP1_HUMAN 3.00E-59 GO:0006915; GO:0001825; GO:0051026; GO:0005694; GO:0016874; GO:0005634; GO:0035265; GO:0016567; GO:0007286; GO:0008270 P62972; P14635 apoptotic process; blastocyst formation; chiasma assembly; chromosome; ligase activity; nucleus; organ growth; protein ubiquitination; spermatid development; zinc ion binding IPR001841; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase CCNB1IP1 (EC 6.3.2.-) (Cyclin-B1-interacting protein 1) (Human enhancer of invasion 10) CCNB1IP1 C14orf18 HEI10 Homo sapiens (Human) TR27832_c4_g1_i1 Q28DR4 H4_XENTR 3.00E-29 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR001951; IPR019809; Histone H4 TGas006m08.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR27832_c4_g2_i2 Q6WV88 H2A_MYTGA 3.00E-50 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR002119; Histone H2A Mytilus galloprovincialis (Mediterranean mussel) TR27832_c4_g2_i3 Q6WV88 H2A_MYTGA 1.00E-51 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR002119; Histone H2A Mytilus galloprovincialis (Mediterranean mussel) TR27832_c4_g4_i1 P19374 H2B_PLADU 4.00E-51 GO:0003677; GO:0005811; GO:0000786; GO:0006334; GO:0005634 DNA binding; lipid particle; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR000558; Histone H2B Platynereis dumerilii (Dumeril's clam worm) TR27833_c0_g1_i1 Q9BUH6 CI142_HUMAN 5.00E-08 IPR027873; Uncharacterized protein C9orf142 C9orf142 Homo sapiens (Human) TR27837_c0_g1_i1 Q91W78 USB1_MOUSE 6.00E-59 GO:0000175; GO:0008380; GO:0034477; GO:0006397; GO:0005634 3'-5'-exoribonuclease activity; RNA splicing; U6 snRNA 3'-end processing; mRNA processing; nucleus IPR009097; IPR027521; U6 snRNA phosphodiesterase (EC 3.1.4.-) Usb1 Mus musculus (Mouse) TR27839_c0_g1_i1 Q3T0P5 CASP6_BOVIN 4.00E-09 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-6 (CASP-6) (EC 3.4.22.59) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11] CASP6 Bos taurus (Bovine) TR27839_c0_g1_i3 P97864 CASP7_MOUSE 2.00E-16 GO:0004190; GO:0097153; GO:0005737; GO:0097194; GO:0007507; GO:0005634; GO:0043525; GO:0016485; GO:0006508; GO:0001836; GO:0009411 P11103; P62270 aspartic-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cytoplasm; execution phase of apoptosis; heart development; nucleus; positive regulation of neuron apoptotic process; protein processing; proteolysis; release of cytochrome c from mitochondria; response to UV IPR015471; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; "Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11; Caspase-7, N-terminally processed]" Casp7 Lice2 Mch3 Mus musculus (Mouse) TR27839_c0_g1_i4 Q5IS99 CASP3_SAIBB 3.00E-16 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Saimiri boliviensis boliviensis (Bolivian squirrel monkey) TR27842_c0_g1_i1 A8WQK3 ACH1_CAEBR 2.00E-84 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha-type acr-16 acr-16 CBG01491 Caenorhabditis briggsae TR27843_c3_g2_i1 Q2EMV9 PAR14_MOUSE 4.00E-24 GO:0003950; GO:0005737; GO:0003676; GO:0005634; GO:0005886; GO:0006355; GO:0006351 P06745 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleic acid binding; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR000504; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) TR27843_c5_g1_i1 B5F961 YMDB_SALA4 2.00E-10 GO:0019213; GO:0060701; GO:0001883; GO:0042278; GO:0008428 deacetylase activity; negative regulation of ribonuclease activity; purine nucleoside binding; purine nucleoside metabolic process; ribonuclease inhibitor activity IPR002589; IPR024900; O-acetyl-ADP-ribose deacetylase (EC 3.5.1.-) (Regulator of RNase III activity) ymdB SeAg_B2042 Salmonella agona (strain SL483) TR27848_c0_g1_i1 Q03957 CTK1_YEAST 8.00E-23 GO:0005524; GO:0008353; GO:0032806; GO:0004693; GO:0005737; GO:0031124; GO:0005730; GO:0005654; GO:0018105; GO:0070816; GO:0032786; GO:0045943; GO:0045903; GO:0006974; GO:0006351; GO:0006412 P46962; P46963; P25555 "ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; carboxy-terminal domain protein kinase complex; cyclin-dependent protein serine/threonine kinase activity; cytoplasm; mRNA 3'-end processing; nucleolus; nucleoplasm; peptidyl-serine phosphorylation; phosphorylation of RNA polymerase II C-terminal domain; positive regulation of DNA-dependent transcription, elongation; positive regulation of transcription from RNA polymerase I promoter; positive regulation of translational fidelity; response to DNA damage stimulus; transcription, DNA-dependent; translation" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; CTD kinase subunit alpha (CTDK-I subunit alpha) (EC 2.7.11.23) (CTD kinase 58 kDa subunit) (CTD kinase subunit 1) CTK1 YKL139W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR27848_c0_g1_i3 Q3SZW1 TSSK1_BOVIN 6.00E-61 GO:0005524; GO:0001669; GO:0046872; GO:0031514; GO:0007275; GO:0004674; GO:0007286 ATP binding; acrosomal vesicle; metal ion binding; motile cilium; multicellular organismal development; protein serine/threonine kinase activity; spermatid development IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Testis-specific serine/threonine-protein kinase 1 (TSK-1) (TSK1) (TSSK-1) (Testis-specific kinase 1) (EC 2.7.11.1) TSSK1B TSSK1 Bos taurus (Bovine) TR27851_c4_g1_i1 P26818 ARBK2_BOVIN 5.00E-171 GO:0005524; GO:0004703; GO:0047696; GO:0005543; GO:0031623; GO:0007165; GO:0038032 ATP binding; G-protein coupled receptor kinase activity; beta-adrenergic receptor kinase activity; phospholipid binding; receptor internalization; signal transduction; termination of G-protein coupled receptor signaling pathway IPR000961; IPR000239; IPR011009; IPR011993; IPR001849; IPR000719; IPR017441; IPR016137; IPR000342; IPR002290; IPR008271; Beta-adrenergic receptor kinase 2 (Beta-ARK-2) (EC 2.7.11.15) (G-protein-coupled receptor kinase 3) ADRBK2 GRK3 Bos taurus (Bovine) TR27852_c0_g1_i1 Q5EA28 CXXC1_BOVIN 6.00E-72 GO:0003677; GO:0048188; GO:0016363; GO:0016607; GO:0006355; GO:0006351; GO:0008270 "DNA binding; Set1C/COMPASS complex; nuclear matrix; nuclear speck; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR022056; IPR019786; IPR002857; IPR011011; IPR001965; IPR019787; IPR013083; CpG-binding protein (CXXC-type zinc finger protein 1) (PHD finger and CXXC domain-containing protein 1) CXXC1 Bos taurus (Bovine) TR27852_c0_g1_i2 Q5EA28 CXXC1_BOVIN 7.00E-72 GO:0003677; GO:0048188; GO:0016363; GO:0016607; GO:0006355; GO:0006351; GO:0008270 "DNA binding; Set1C/COMPASS complex; nuclear matrix; nuclear speck; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR022056; IPR019786; IPR002857; IPR011011; IPR001965; IPR019787; IPR013083; CpG-binding protein (CXXC-type zinc finger protein 1) (PHD finger and CXXC domain-containing protein 1) CXXC1 Bos taurus (Bovine) TR27854_c0_g1_i1 Q7Z5L0 VMO1_HUMAN 7.00E-42 GO:0005576; GO:0030704 extracellular region; vitelline membrane formation IPR005515; Vitelline membrane outer layer protein 1 homolog VMO1 UNQ6350/PRO21055 Homo sapiens (Human) TR27855_c0_g1_i2 Q6NXP6 NXRD1_HUMAN 3.00E-20 GO:0006561; GO:0004735 proline biosynthetic process; pyrroline-5-carboxylate reductase activity IPR016040; IPR000304; NADP-dependent oxidoreductase domain-containing protein 1 (EC 1.-.-.-) (Pyrroline-5-carboxylate reductase-like protein C14orf148) NOXRED1 C14orf148 Homo sapiens (Human) TR27855_c1_g1_i1 A0JM24 NXRD1_XENTR 4.00E-21 GO:0006561; GO:0004735 proline biosynthetic process; pyrroline-5-carboxylate reductase activity IPR016040; IPR000304; NADP-dependent oxidoreductase domain-containing protein 1 (EC 1.-.-.-) (Pyrroline-5-carboxylate reductase-like protein C14orf148 homolog) noxred1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR27859_c3_g1_i1 Q86Y13 DZIP3_HUMAN 4.00E-07 GO:0003723; GO:0005737; GO:0019902; GO:0031593; GO:0000209; GO:0004842; GO:0008270 Q9H0E2 RNA binding; cytoplasm; phosphatase binding; polyubiquitin binding; protein polyubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) TR27860_c10_g1_i1 Q6DFV8 VWDE_MOUSE 1.00E-09 GO:0005576 extracellular region IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) TR27866_c0_g1_i1 Q95KI1 TB22A_MACFA 9.00E-77 GO:0005097; GO:0032851; GO:0042803 Rab GTPase activator activity; positive regulation of Rab GTPase activity; protein homodimerization activity IPR000195; TBC1 domain family member 22A (Fragment) TBC1D22A QtrA-11492 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR27866_c0_g3_i1 Q08484 GYP1_YEAST 3.00E-34 GO:0005794; GO:0005795; GO:0005097; GO:0016192 Golgi apparatus; Golgi stack; Rab GTPase activator activity; vesicle-mediated transport IPR000195; GTPase-activating protein GYP1 (GAP for YPT1) GYP1 YOR070C YOR29-21 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR27867_c0_g1_i1 Q8BUV8 GP107_MOUSE 4.00E-128 GO:0016021 integral to membrane IPR009637; Protein GPR107 Gpr107 Kiaa1624 Mus musculus (Mouse) TR27870_c0_g1_i1 Q09296 CBPC6_CAEEL 2.00E-130 GO:0005737; GO:0004181; GO:0035608; GO:0006508; GO:0008270 cytoplasm; metallocarboxypeptidase activity; protein deglutamylation; proteolysis; zinc ion binding IPR000834; Cytosolic carboxypeptidase 6 (EC 3.4.17.-) (ATP/GTP-binding protein-like 4 homolog) (CeAGBL4) ccpp-6 EEED8.6 Caenorhabditis elegans TR27870_c0_g1_i3 Q09LZ8 CBPC6_MOUSE 0 GO:0035609; GO:0005829; GO:0004181; GO:0035610; GO:0006508; GO:0015631; GO:0008270 C-terminal protein deglutamylation; cytosol; metallocarboxypeptidase activity; protein side chain deglutamylation; proteolysis; tubulin binding; zinc ion binding IPR000834; Cytosolic carboxypeptidase 6 (EC 3.4.17.-) (ATP/GTP-binding protein-like 4) Agbl4 Ccp6 Mus musculus (Mouse) TR27871_c0_g1_i1 Q9N1Q0 RSMB_MACEU 2.00E-51 GO:0008380; GO:0005689; GO:0005683; GO:0071013; GO:0005737; GO:0071204; GO:0071208; GO:0006397 RNA splicing; U12-type spliceosomal complex; U7 snRNP; catalytic step 2 spliceosome; cytoplasm; histone pre-mRNA 3'end processing complex; histone pre-mRNA DCP binding; mRNA processing IPR010920; IPR001163; IPR006649; IPR017131; Small nuclear ribonucleoprotein-associated protein B' (snRNP-B') (snRPB') (Sm protein B') (Sm-B') (SmB') SNRPB Macropus eugenii (Tammar wallaby) TR27874_c0_g2_i2 Q9Z0E1 CB065_MOUSE 2.00E-39 GO:0006396; GO:0030154; GO:0031497; GO:0005737; GO:0007292; GO:0016021; GO:0051308; GO:0007283 RNA processing; cell differentiation; chromatin assembly; cytoplasm; female gamete generation; integral to membrane; male meiosis chromosome separation; spermatogenesis IPR025891; Meiosis 1 arrest protein (Meiosis 1-arresting protein) (Meiosis 1-associated protein) (Spermatogenesis-associated protein 37) M1ap D6Mm5e Spata37 Mus musculus (Mouse) TR27878_c0_g1_i1 P36406 TRI23_HUMAN 0 GO:0019003; GO:0005525; GO:0003924; GO:0000139; GO:0008047; GO:0005765; GO:0019048; GO:0005634; GO:0007264; GO:0004842; GO:0008270 Itself; P55040; P09022 GDP binding; GTP binding; GTPase activity; Golgi membrane; enzyme activator activity; lysosomal membrane; modulation by virus of host morphology or physiology; nucleus; small GTPase mediated signal transduction; ubiquitin-protein ligase activity; zinc ion binding IPR003649; IPR027417; IPR005225; IPR024156; IPR006689; IPR000315; IPR007087; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM23 (EC 6.3.2.-) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (Tripartite motif-containing protein 23) TRIM23 ARD1 ARFD1 RNF46 Homo sapiens (Human) TR27878_c0_g1_i2 Q9FY48 KEG_ARATH 1.00E-07 GO:0005524; GO:0005794; GO:0009738; GO:0006952; GO:0048589; GO:0005769; GO:0016197; GO:0009788; GO:0004672; GO:0004674; GO:0032940; GO:0005802; GO:0004842; GO:0008270 Q9SJN0 ATP binding; Golgi apparatus; abscisic acid mediated signaling pathway; defense response; developmental growth; early endosome; endosomal transport; negative regulation of abscisic acid mediated signaling pathway; protein kinase activity; protein serine/threonine kinase activity; secretion by cell; trans-Golgi network; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR011009; IPR000719; IPR027370; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase KEG (EC 2.7.11.1) (EC 6.3.2.-) (Protein KEEP ON GOING) (RING finger protein KEG) KEG At5g13530 T6I14.60 T6I14.70 Arabidopsis thaliana (Mouse-ear cress) TR27880_c1_g1_i1 Q922K9 FRK_MOUSE 2.00E-11 GO:0005524; GO:0005737; GO:0004715; GO:0005634; GO:0018108 ATP binding; cytoplasm; non-membrane spanning protein tyrosine kinase activity; nucleus; peptidyl-tyrosine phosphorylation IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase FRK (EC 2.7.10.2) (Beta-cell Src-homology tyrosine kinase) (BSK) (FYN-related kinase) (Intestine tyrosine kinase) Frk Bsk Iyk Mus musculus (Mouse) TR27880_c1_g1_i2 Q62077 PLCG1_MOUSE 3.00E-13 GO:0050852; GO:0005509; GO:0071364; GO:0005829; GO:0001701; GO:0035556; GO:0030027; GO:0004435; GO:0005543; GO:0009395; GO:0010634; GO:0001726; GO:0004871 P14753; Q60631; O54957; P48356 T cell receptor signaling pathway; calcium ion binding; cellular response to epidermal growth factor stimulus; cytosol; in utero embryonic development; intracellular signal transduction; lamellipodium; phosphatidylinositol phospholipase C activity; phospholipid binding; phospholipid catabolic process; positive regulation of epithelial cell migration; ruffle; signal transducer activity IPR000008; IPR011992; IPR018247; IPR002048; IPR011993; IPR001192; IPR016279; IPR017946; IPR001849; IPR015359; IPR000909; IPR001711; IPR000980; IPR001452; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-gamma-1) (PLC-gamma-1)" Plcg1 Plcg-1 Mus musculus (Mouse) TR27880_c1_g1_i4 P52735 VAV2_HUMAN 2.00E-06 GO:0038095; GO:0038096; GO:0005089; GO:0001525; GO:0097190; GO:0007411; GO:0016477; GO:0005829; GO:0005085; GO:0045087; GO:0030032; GO:0046872; GO:0048011; GO:0005543; GO:0005886; GO:0030168; GO:0043065; GO:0043552; GO:0035023; GO:0051056; GO:0007264 Q8IZP0; P04626; P51956; P78314; O75674 Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; Rho guanyl-nucleotide exchange factor activity; angiogenesis; apoptotic signaling pathway; axon guidance; cell migration; cytosol; guanyl-nucleotide exchange factor activity; innate immune response; lamellipodium assembly; metal ion binding; neurotrophin TRK receptor signaling pathway; phospholipid binding; plasma membrane; platelet activation; positive regulation of apoptotic process; positive regulation of phosphatidylinositol 3-kinase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR001715; IPR000219; IPR001331; IPR011993; IPR001849; IPR002219; IPR000980; IPR011511; IPR001452; Guanine nucleotide exchange factor VAV2 (VAV-2) VAV2 Homo sapiens (Human) TR27882_c1_g1_i1 Q5ZM55 FEM1B_CHICK 3.00E-08 GO:0006915; GO:0005737; GO:0005634; GO:0016567; GO:2000001 apoptotic process; cytoplasm; nucleus; protein ubiquitination; regulation of DNA damage checkpoint IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog B (FEM1b) (FEM1-beta) FEM1B RCJMB04_3b14 Gallus gallus (Chicken) TR27882_c1_g1_i2 Q8WVL7 ANR49_HUMAN 1.00E-09 GO:0005634; GO:0045893 "nucleus; positive regulation of transcription, DNA-dependent" IPR002110; IPR020683; Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor) ANKRD49 FGIF Homo sapiens (Human) TR27883_c5_g1_i1 O42601 S17B1_XENLA 5.00E-21 GO:0016055; GO:0008013; GO:0007492; GO:0007369; GO:0007494; GO:0030178; GO:0000122; GO:0005634; GO:0045944; GO:0043565; GO:0006351 "Wnt receptor signaling pathway; beta-catenin binding; endoderm development; gastrulation; midgut development; negative regulation of Wnt receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent" IPR009071; IPR021934; Transcription factor Sox-17-beta.1 (SRY (sex determining region Y)-box 17-beta.1) (Transcription factor Sox-17-beta) (XSox17beta) sox17b.1 sox17b Xenopus laevis (African clawed frog) TR27887_c0_g1_i1 P33274 CP4F1_RAT 4.00E-109 GO:0050544; GO:0019369; GO:0008391; GO:0070330; GO:0005789; GO:0020037; GO:0043231; GO:0005506; GO:0009636 arachidonic acid binding; arachidonic acid metabolic process; arachidonic acid monooxygenase activity; aromatase activity; endoplasmic reticulum membrane; heme binding; intracellular membrane-bounded organelle; iron ion binding; response to toxic substance IPR001128; IPR017972; IPR002401; Cytochrome P450 4F1 (EC 1.14.14.1) (CYPIVF1) (Cytochrome P450-A3) Cyp4f1 Cyp4f-1 Cyp4f2 Rattus norvegicus (Rat) TR27893_c0_g1_i1 A4IHD2 ARIP4_XENTR 2.00E-10 GO:0005524; GO:0003677; GO:0004386; GO:0005634 ATP binding; DNA binding; helicase activity; nucleus IPR014001; IPR001650; IPR027417; IPR000330; Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) rad54l2 arip4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR27893_c6_g1_i1 A4IHD2 ARIP4_XENTR 1.00E-68 GO:0005524; GO:0003677; GO:0004386; GO:0005634 ATP binding; DNA binding; helicase activity; nucleus IPR014001; IPR001650; IPR027417; IPR000330; Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) rad54l2 arip4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR27899_c2_g2_i1 Q7Z7G8 VP13B_HUMAN 4.00E-79 GO:0015031 protein transport IPR015412; IPR026854; IPR009543; Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1) VPS13B CHS1 COH1 KIAA0532 Homo sapiens (Human) TR27899_c2_g2_i2 Q80TY5 VP13B_MOUSE 2.00E-76 GO:0015031 protein transport IPR015412; IPR026854; IPR009543; Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1 homolog) Vps13b Coh1 Kiaa0532 Mus musculus (Mouse) TR2790_c0_g1_i1 Q6TCG8 PAQR3_MOUSE 1.00E-39 GO:0000139; GO:0016021 Golgi membrane; integral to membrane IPR004254; Progestin and adipoQ receptor family member 3 (Progestin and adipoQ receptor family member III) (Raf kinase trapping to Golgi) (RKTG) Paqr3 Mus musculus (Mouse) TR27900_c1_g1_i1 Q9WVH6 ANGP4_MOUSE 3.00E-26 GO:0048014; GO:0001525; GO:0071456; GO:0007492; GO:0005615; GO:0016525; GO:0043066; GO:0043537; GO:0045766; GO:0043536; GO:0030297; GO:0005172 Tie signaling pathway; angiogenesis; cellular response to hypoxia; endoderm development; extracellular space; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of blood vessel endothelial cell migration; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; transmembrane receptor protein tyrosine kinase activator activity; vascular endothelial growth factor receptor binding IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3) Angpt4 Agpt4 Ang3 Mus musculus (Mouse) TR27900_c1_g2_i1 P19477 FIBA_PARPA 2.00E-20 IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein A (FREP-A) Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) TR27901_c0_g1_i2 A4Q9F6 TTL13_MOUSE 6.00E-123 GO:0006464; GO:0016874 cellular protein modification process; ligase activity IPR004344; Tubulin polyglutamylase TTLL13 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 13) Ttll13 Mus musculus (Mouse) TR27902_c1_g2_i1 Q9QZR0 RNF25_MOUSE 5.00E-56 GO:0051059; GO:0005829; GO:0005634; GO:0051092; GO:0004842; GO:0008270 NF-kappaB binding; cytosol; nucleus; positive regulation of NF-kappaB transcription factor activity; ubiquitin-protein ligase activity; zinc ion binding IPR006575; IPR016135; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF25 (EC 6.3.2.-) (RING finger protein 25) (RING finger protein AO7) Rnf25 Mus musculus (Mouse) TR27903_c0_g1_i1 P0CW27 CC166_HUMAN 7.00E-15 Coiled-coil domain-containing protein 166 CCDC166 Homo sapiens (Human) TR27905_c0_g1_i1 Q9HAJ7 SP30L_HUMAN 2.00E-67 GO:0003677; GO:0046872; GO:0005730; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleolus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR024145; IPR025718; IPR025717; Histone deacetylase complex subunit SAP30L (HCV non-structural protein 4A-transactivated protein 2) (Sin3 corepressor complex subunit SAP30L) (Sin3-associated protein p30-like) SAP30L NS4ATP2 Homo sapiens (Human) TR27908_c1_g1_i1 Q567G6 CC017_DANRE 1.00E-13 GO:0016021 integral to membrane IPR027951; Uncharacterized protein C3orf17 homolog si:dkey-22a1.3 zgc:112065 Danio rerio (Zebrafish) (Brachydanio rerio) TR27909_c0_g1_i1 Q61555 FBN2_MOUSE 3.00E-06 GO:0060346; GO:0005509; GO:0030326; GO:0005201; GO:0001527; GO:0030501; GO:0045669; GO:0035583 bone trabecula formation; calcium ion binding; embryonic limb morphogenesis; extracellular matrix structural constituent; microfibril; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; sequestering of TGFbeta in extracellular matrix IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR011398; IPR009030; IPR017878; Fibrillin-2 Fbn2 Fbn-2 Mus musculus (Mouse) TR27909_c0_g2_i1 P07207 NOTCH_DROME 5.00E-07 GO:0005796; GO:0061382; GO:0007219; GO:0048052; GO:0007464; GO:0045466; GO:0045463; GO:0007460; GO:0007015; GO:0005912; GO:0008356; GO:0007298; GO:0005509; GO:0009986; GO:0008407; GO:0003682; GO:0042676; GO:0046667; GO:0005829; GO:0008340; GO:0046843; GO:0007391; GO:0007451; GO:0007398; GO:0035165; GO:0005788; GO:0005768; GO:0061331; GO:0035153; GO:0035214; GO:0007440; GO:0060288; GO:0030718; GO:0030708; GO:0007403; GO:0008347; GO:0035172; GO:0007157; GO:0007446; GO:0016348; GO:0048803; GO:0008587; GO:0007474; GO:0016021; GO:0035171; GO:0046331; GO:0007616; GO:0035170; GO:0007498; GO:0008045; GO:0007521; GO:0046329; GO:0045316; GO:0035157; GO:0050768; GO:0035155; GO:0000122; GO:0007400; GO:0005654; GO:0007314; GO:0030720; GO:0030713; GO:0007422; GO:1900087; GO:0045747; GO:0008284; GO:0045944; GO:0043234; GO:0045468; GO:0042686; GO:0042689; GO:0051489; GO:0040008; GO:0009608; GO:0016330; GO:0007519; GO:0035003; GO:0006351; GO:0004888; GO:0007419; GO:0048190; GO:0007473 Q24279; P10041; P28159 "Golgi lumen; Malpighian tubule tip cell differentiation; Notch signaling pathway; R1/R6 cell differentiation; R3/R4 cell fate commitment; R7 cell differentiation; R8 cell development; R8 cell fate commitment; actin filament organization; adherens junction; asymmetric cell division; border follicle cell migration; calcium ion binding; cell surface; chaeta morphogenesis; chromatin binding; compound eye cone cell fate commitment; compound eye retinal cell programmed cell death; cytosol; determination of adult lifespan; dorsal appendage formation; dorsal closure; dorsal/ventral lineage restriction, imaginal disc; ectoderm development; embryonic crystal cell differentiation; endoplasmic reticulum lumen; endosome; epithelial cell proliferation involved in Malpighian tubule morphogenesis; epithelial cell type specification, open tracheal system; eye-antennal disc development; foregut morphogenesis; formation of a compartment boundary; germ-line stem cell maintenance; germarium-derived female germ-line cyst encapsulation; glial cell fate determination; glial cell migration; hemocyte proliferation; heterophilic cell-cell adhesion; imaginal disc growth; imaginal disc-derived leg joint morphogenesis; imaginal disc-derived male genitalia morphogenesis; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein specification; integral to membrane; lamellocyte differentiation; lateral inhibition; long-term memory; lymph gland crystal cell differentiation; mesoderm development; motor neuron axon guidance; muscle cell fate determination; negative regulation of JNK cascade; negative regulation of compound eye photoreceptor development; negative regulation of fusion cell fate specification; negative regulation of neurogenesis; negative regulation of terminal cell fate specification, open tracheal system; negative regulation of transcription from RNA polymerase II promoter; neuroblast fate determination; nucleoplasm; oocyte anterior/posterior axis specification; oocyte localization involved in germarium-derived egg chamber formation; ovarian follicle cell stalk formation; peripheral nervous system development; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of Notch signaling pathway; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; protein complex; regulation of R8 cell spacing in compound eye; regulation of cardioblast cell fate specification; regulation of crystal cell differentiation; regulation of filopodium assembly; regulation of growth; response to symbiont; second mitotic wave involved in compound eye morphogenesis; skeletal muscle tissue development; subapical complex; transcription, DNA-dependent; transmembrane signaling receptor activity; ventral cord development; wing disc dorsal/ventral pattern formation; wing disc proximal/distal pattern formation" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR000800; IPR010660; IPR011656; Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) TR27909_c1_g2_i1 Q06441 TSP4_XENLA 7.00E-31 GO:0005509; GO:0007155; GO:0031012; GO:0005615; GO:0051781; GO:0016529 calcium ion binding; cell adhesion; extracellular matrix; extracellular space; positive regulation of cell division; sarcoplasmic reticulum IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR018097; IPR023413; IPR009030; IPR001791; IPR024665; IPR003367; IPR017897; IPR008859; Thrombospondin-4 thbs4 tsp4 Xenopus laevis (African clawed frog) TR27920_c1_g2_i1 Q97E97 PTH_CLOAB 2.00E-17 GO:0004045; GO:0005737 aminoacyl-tRNA hydrolase activity; cytoplasm IPR001328; IPR018171; Peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29) pth CA_C3217 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) TR27920_c1_g2_i4 Q8BW00 PTH_MOUSE 2.00E-25 GO:0004045; GO:0005739 aminoacyl-tRNA hydrolase activity; mitochondrion IPR001328; IPR018171; Probable peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29) Ptrh1 Mus musculus (Mouse) TR27923_c0_g2_i1 Q5E9P5 PAMR1_BOVIN 6.00E-07 GO:0003824; GO:0005576; GO:0008152 catalytic activity; extracellular region; metabolic process IPR000859; IPR000742; IPR013032; IPR001254; IPR001314; IPR000436; IPR009003; Inactive serine protease PAMR1 (Peptidase domain-containing protein associated with muscle regeneration 1) (Regeneration-associated muscle protease homolog) PAMR1 RAMP Bos taurus (Bovine) TR27923_c2_g1_i1 Q9JLB4 CUBN_MOUSE 1.00E-25 GO:0005794; GO:0016324; GO:0005903; GO:0005509; GO:0008203; GO:0005905; GO:0031419; GO:0030139; GO:0005783; GO:0005768; GO:0010008; GO:0042953; GO:0005765; GO:0004872; GO:0006898 Golgi apparatus; apical plasma membrane; brush border; calcium ion binding; cholesterol metabolic process; coated pit; cobalamin binding; endocytic vesicle; endoplasmic reticulum; endosome; endosome membrane; lipoprotein transport; lysosomal membrane; receptor activity; receptor-mediated endocytosis IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; Cubilin (Intrinsic factor-cobalamin receptor) Cubn Ifcr Mus musculus (Mouse) TR27923_c2_g1_i2 Q7RTZ1 OVCH2_HUMAN 4.00E-11 GO:0005576; GO:0046872; GO:0006508; GO:0004252 extracellular region; metal ion binding; proteolysis; serine-type endopeptidase activity IPR000859; IPR001254; IPR018114; IPR001314; IPR009003; Ovochymase-2 (EC 3.4.21.-) (Oviductin) OVCH2 OVTN Homo sapiens (Human) TR27923_c2_g1_i3 P25723 TLD_DROME 9.00E-16 GO:0007378; GO:0005509; GO:0005576; GO:0008586; GO:0007313; GO:0004222; GO:0010629; GO:0030513; GO:0016485; GO:0006508; GO:0017015; GO:0007362; GO:0008293; GO:0008270 "amnioserosa formation; calcium ion binding; extracellular region; imaginal disc-derived wing vein morphogenesis; maternal specification of dorsal/ventral axis, oocyte, soma encoded; metalloendopeptidase activity; negative regulation of gene expression; positive regulation of BMP signaling pathway; protein processing; proteolysis; regulation of transforming growth factor beta receptor signaling pathway; terminal region determination; torso signaling pathway; zinc ion binding" IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Dorsal-ventral patterning protein tolloid (EC 3.4.24.-) tld CG6868 Drosophila melanogaster (Fruit fly) TR27924_c0_g1_i2 Q9QYK3 NRBF2_RAT 2.00E-18 GO:0005737; GO:0005634; GO:2000327; GO:0045893; GO:0006351 "cytoplasm; nucleus; positive regulation of ligand-dependent nuclear receptor transcription coactivator activity; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR015056; Nuclear receptor-binding factor 2 (NRBF-2) Nrbf2 Rattus norvegicus (Rat) TR27924_c0_g1_i3 Q8VCQ3 NRBF2_MOUSE 1.00E-17 GO:0005737; GO:0016922; GO:0005634; GO:0006357; GO:0003713; GO:0005667; GO:0006351 "cytoplasm; ligand-dependent nuclear receptor binding; nucleus; regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcription factor complex; transcription, DNA-dependent" IPR015056; Nuclear receptor-binding factor 2 (NRBF-2) Nrbf2 Mus musculus (Mouse) TR27927_c1_g2_i1 Q62231 SIX1_MOUSE 9.00E-124 GO:0035909; GO:0006915; GO:0001658; GO:0003682; GO:0090103; GO:0005737; GO:0048701; GO:0030855; GO:0021610; GO:0072172; GO:0072075; GO:0042474; GO:0051451; GO:0090191; GO:0043524; GO:0000122; GO:0048665; GO:0005730; GO:0005634; GO:0001759; GO:0071599; GO:0003151; GO:0007389; GO:0060037; GO:0090190; GO:2000729; GO:0072513; GO:0045944; GO:0072107; GO:0034504; GO:0072095; GO:0045664; GO:0032880; GO:0008582; GO:0007605; GO:0043565; GO:0003700; GO:0007519; GO:0048538; GO:0030878; GO:0005667; GO:0044212; GO:0006351; GO:0072193 P97767 "aorta morphogenesis; apoptotic process; branching involved in ureteric bud morphogenesis; chromatin binding; cochlea morphogenesis; cytoplasm; embryonic cranial skeleton morphogenesis; epithelial cell differentiation; facial nerve morphogenesis; mesonephric tubule formation; metanephric mesenchyme development; middle ear morphogenesis; myoblast migration; negative regulation of branching involved in ureteric bud morphogenesis; negative regulation of neuron apoptotic process; negative regulation of transcription from RNA polymerase II promoter; neuron fate specification; nucleolus; nucleus; organ induction; otic vesicle development; outflow tract morphogenesis; pattern specification process; pharyngeal system development; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of mesenchymal cell proliferation involved in ureter development; positive regulation of secondary heart field cardioblast proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of ureteric bud formation; protein localization to nucleus; regulation of branch elongation involved in ureteric bud branching; regulation of neuron differentiation; regulation of protein localization; regulation of synaptic growth at neuromuscular junction; sensory perception of sound; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; skeletal muscle tissue development; thymus development; thyroid gland development; transcription factor complex; transcription regulatory region DNA binding; transcription, DNA-dependent; ureter smooth muscle cell differentiation" IPR017970; IPR001356; IPR009057; Homeobox protein SIX1 (Sine oculis homeobox homolog 1) Six1 Mus musculus (Mouse) TR27927_c1_g2_i2 O42406 SIX3_CHICK 1.00E-77 GO:0003677; GO:0003705; GO:0007420; GO:0001654; GO:0030178; GO:0045892; GO:0005634; GO:0043565 "DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; brain development; eye development; negative regulation of Wnt receptor signaling pathway; negative regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding" IPR001356; IPR009057; Homeobox protein SIX3 (CSIX3) (Sine oculis homeobox homolog 3) SIX3 Gallus gallus (Chicken) TR27928_c0_g1_i1 Q641Z4 CDK9_RAT 1.00E-172 GO:0005524; GO:0006281; GO:0016605; GO:0008353; GO:0071345; GO:0004693; GO:0005737; GO:0071157; GO:0008024; GO:0006282; GO:0031056; GO:0006355; GO:0043111; GO:0044212; GO:0006351 "ATP binding; DNA repair; PML body; RNA polymerase II carboxy-terminal domain kinase activity; cellular response to cytokine stimulus; cyclin-dependent protein serine/threonine kinase activity; cytoplasm; negative regulation of cell cycle arrest; positive transcription elongation factor complex b; regulation of DNA repair; regulation of histone modification; regulation of transcription, DNA-dependent; replication fork arrest; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 9) Cdk9 Rattus norvegicus (Rat) TR27930_c3_g1_i1 Q9CQT2 RBM7_MOUSE 4.00E-20 GO:0003723; GO:0007126; GO:0000166 RNA binding; meiosis; nucleotide binding IPR012677; IPR000504; RNA-binding protein 7 (RNA-binding motif protein 7) Rbm7 Mus musculus (Mouse) TR27933_c0_g1_i1 Q92834 RPGR_HUMAN 3.00E-71 GO:0005794; GO:0005813; GO:0042384; GO:0035085; GO:0036064; GO:0042462; GO:0005085; GO:0006886; GO:0042073; GO:0001750; GO:0050896; GO:0036126; GO:0007601 O43924; O55057 Golgi apparatus; centrosome; cilium assembly; cilium axoneme; cilium basal body; eye photoreceptor cell development; guanyl-nucleotide exchange factor activity; intracellular protein transport; intraflagellar transport; photoreceptor outer segment; response to stimulus; sperm flagellum; visual perception IPR009091; IPR000408; X-linked retinitis pigmentosa GTPase regulator RPGR RP3 XLRP3 Homo sapiens (Human) TR2794_c0_g1_i1 Q96DL1 NXPE2_HUMAN 7.00E-12 GO:0016021 integral to membrane IPR014756; IPR026845; NXPE family member 2 (Protein FAM55B) NXPE2 FAM55B Homo sapiens (Human) TR27941_c0_g1_i1 Q3UIR3 DTX3L_MOUSE 5.00E-27 GO:0005737; GO:0006302; GO:0042393; GO:0010390; GO:0005634; GO:0004842; GO:0008270 cytoplasm; double-strand break repair; histone binding; histone monoubiquitination; nucleus; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (Protein deltex-3-like) Dtx3l Bbap Mus musculus (Mouse) TR27941_c1_g2_i2 Q3UIR3 DTX3L_MOUSE 1.00E-57 GO:0005737; GO:0006302; GO:0042393; GO:0010390; GO:0005634; GO:0004842; GO:0008270 cytoplasm; double-strand break repair; histone binding; histone monoubiquitination; nucleus; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (Protein deltex-3-like) Dtx3l Bbap Mus musculus (Mouse) TR27941_c1_g2_i4 Q5REG4 DTX3_PONAB 8.00E-57 GO:0007219; GO:0005737; GO:0016874; GO:0016567; GO:0008270 Notch signaling pathway; cytoplasm; ligase activity; protein ubiquitination; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase DTX3 (EC 6.3.2.-) (Protein deltex-3) (Deltex3) DTX3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR27942_c0_g1_i1 Q5I0E3 CG050_RAT 7.00E-21 IPR019327; Uncharacterized protein C7orf50 homolog Rattus norvegicus (Rat) TR27942_c0_g1_i2 Q5I0E3 CG050_RAT 7.00E-21 IPR019327; Uncharacterized protein C7orf50 homolog Rattus norvegicus (Rat) TR27943_c2_g1_i1 Q15399 TLR1_HUMAN 2.00E-07 GO:0002755; GO:0042088; GO:0035354; GO:0071727; GO:0042496; GO:0042495; GO:0006955; GO:0006954; GO:0045087; GO:0005887; GO:0042116; GO:0030670; GO:0045410; GO:0042535; GO:0046982; GO:0050707; GO:0034150; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; T-helper 1 type immune response; Toll-like receptor 1-Toll-like receptor 2 protein complex; cellular response to triacyl bacterial lipopeptide; detection of diacyl bacterial lipopeptide; detection of triacyl bacterial lipopeptide; immune response; inflammatory response; innate immune response; integral to plasma membrane; macrophage activation; phagocytic vesicle membrane; positive regulation of interleukin-6 biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; protein heterodimerization activity; regulation of cytokine secretion; toll-like receptor 6 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR000157; IPR027187; IPR017241; Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) TLR1 KIAA0012 Homo sapiens (Human) TR27944_c2_g1_i1 Q24372 LACH_DROME 8.00E-27 GO:0031225; GO:0061343; GO:0007156; GO:0035160; GO:0016331; GO:0005886; GO:0042803; GO:0035151; GO:0005918; GO:0019991 Q9VGH2 "anchored to membrane; cell adhesion involved in heart morphogenesis; homophilic cell adhesion; maintenance of epithelial integrity, open tracheal system; morphogenesis of embryonic epithelium; plasma membrane; protein homodimerization activity; regulation of tube size, open tracheal system; septate junction; septate junction assembly" IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Lachesin Lac CG12369 Drosophila melanogaster (Fruit fly) TR27947_c0_g1_i1 Q5RC21 TSNAX_PONAB 1.00E-76 GO:0005794; GO:0030154; GO:0046872; GO:0007275; GO:0005634; GO:0048471; GO:0043565; GO:0007283 Golgi apparatus; cell differentiation; metal ion binding; multicellular organismal development; nucleus; perinuclear region of cytoplasm; sequence-specific DNA binding; spermatogenesis IPR002848; IPR016069; IPR016068; Translin-associated protein X (Translin-associated factor X) TSNAX TRAX Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR27948_c2_g2_i1 E2RYF8 TPX2_ASTPE 4.00E-19 GO:0005737; GO:0005874; GO:0007067; GO:0005634; GO:0005819 cytoplasm; microtubule; mitosis; nucleus; spindle IPR027330; IPR009675; Targeting protein for Xklp2 homolog (TPX2 homolog) (Microtubule-associated protein TPX2 homolog) TPX2 Patiria pectinifera (Starfish) (Asterina pectinifera) TR27951_c0_g1_i1 P62184 CALM_RENRE 2.00E-66 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) Renilla reniformis (Sea pansy) TR27959_c0_g1_i1 P48148 RHO1_DROME 7.00E-116 GO:0005525; GO:0003924; GO:0007254; GO:0016055; GO:0051017; GO:0007298; GO:0035147; GO:0005938; GO:0090254; GO:0070451; GO:0007349; GO:0030866; GO:0005856; GO:0048813; GO:0070593; GO:0007368; GO:0046663; GO:0007395; GO:0006897; GO:0007173; GO:0001737; GO:0045184; GO:0008354; GO:0007377; GO:0008347; GO:0035099; GO:0035149; GO:0045199; GO:0035006; GO:0008045; GO:0007405; GO:0016318; GO:0007422; GO:0005886; GO:0071902; GO:0007374; GO:0030589; GO:0035298; GO:0050770; GO:0051493; GO:0016476; GO:0035159; GO:0006974; GO:0007435; GO:0007264; GO:0035277; GO:0007370; GO:0007601; GO:0042060 "GTP binding; GTPase activity; JNK cascade; Wnt receptor signaling pathway; actin filament bundle assembly; border follicle cell migration; branch fusion, open tracheal system; cell cortex; cell elongation involved in imaginal disc-derived wing morphogenesis; cell hair; cellularization; cortical actin cytoskeleton organization; cytoskeleton; dendrite morphogenesis; dendrite self-avoidance; determination of left/right symmetry; dorsal closure, leading edge cell differentiation; dorsal closure, spreading of leading edge cells; endocytosis; epidermal growth factor receptor signaling pathway; establishment of imaginal disc-derived wing hair orientation; establishment of protein localization; germ cell migration; germ-band extension; glial cell migration; hemocyte migration; lumen formation, open tracheal system; maintenance of epithelial cell apical/basal polarity; melanization defense response; motor neuron axon guidance; neuroblast proliferation; ommatidial rotation; peripheral nervous system development; plasma membrane; positive regulation of protein serine/threonine kinase activity; posterior midgut invagination; pseudocleavage involved in syncytial blastoderm formation; regulation of Malpighian tubule size; regulation of axonogenesis; regulation of cytoskeleton organization; regulation of embryonic cell shape; regulation of tube length, open tracheal system; response to DNA damage stimulus; salivary gland morphogenesis; small GTPase mediated signal transduction; spiracle morphogenesis, open tracheal system; ventral furrow formation; visual perception; wound healing" IPR027417; IPR005225; IPR001806; IPR003578; Ras-like GTP-binding protein Rho1 Rho1 CG8416 Drosophila melanogaster (Fruit fly) TR27959_c0_g1_i2 P41914 RAN_TETPY 8.00E-17 GO:0005525; GO:0003924; GO:0006886; GO:0006913; GO:0005634; GO:0007264 GTP binding; GTPase activity; intracellular protein transport; nucleocytoplasmic transport; nucleus; small GTPase mediated signal transduction IPR027417; IPR002041; IPR005225; IPR001806; GTP-binding nuclear protein Ran (GTPase Ran) (Ras-like protein TC4) Tetrahymena pyriformis TR27961_c0_g1_i1 Q95YM8 MBLK1_APIME 9.00E-22 GO:0007613; GO:0005634; GO:0045893; GO:0042803; GO:0043565; GO:0006351 "memory; nucleus; positive regulation of transcription, DNA-dependent; protein homodimerization activity; sequence-specific DNA binding; transcription, DNA-dependent" IPR009057; IPR007889; Mushroom body large-type Kenyon cell-specific protein 1 Mblk-1 Apis mellifera (Honeybee) TR27962_c1_g1_i1 Q6NRS2 PQLC1_XENLA 3.00E-78 GO:0016021 integral to membrane IPR006603; PQ-loop repeat-containing protein 1 pqlc1 Xenopus laevis (African clawed frog) TR27962_c1_g1_i2 Q03687 YMP0_YEAST 1.00E-07 GO:0016021 integral to membrane IPR006603; Uncharacterized membrane protein YMR010W YMR010W YM8270.13 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR27965_c0_g1_i2 Q9H853 TBA4B_HUMAN 1.00E-37 GO:0005525; GO:0005737; GO:0005874; GO:0007017; GO:0005200 GTP binding; cytoplasm; microtubule; microtubule-based process; structural constituent of cytoskeleton IPR002452; IPR000217; IPR003008; Putative tubulin-like protein alpha-4B (Alpha-tubulin 4B) TUBA4B TUBA4 Homo sapiens (Human) TR27965_c0_g1_i3 P86234 TBA3_MESAU 2.00E-33 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization IPR008280; IPR000217; IPR018316; IPR003008; Tubulin alpha-3 chain (Fragments) Mesocricetus auratus (Golden hamster) TR27965_c0_g1_i4 P41383 TBA2_PATVU 3.00E-103 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-2/alpha-4 chain TUB2; TUB4 Patella vulgata (Common limpet) TR27965_c0_g1_i8 P06605 TBA3_DROME 5.00E-103 GO:0005525; GO:0003924; GO:0005811; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; lipid particle; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-3 chain alphaTub84D TubA84D CG2512 Drosophila melanogaster (Fruit fly) TR27967_c4_g2_i1 Q80VI1 TRI56_MOUSE 1.00E-06 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) TR27968_c1_g1_i1 Q08DU1 UTP23_BOVIN 8.00E-36 GO:0005730; GO:0006364; GO:0032040 nucleolus; rRNA processing; small-subunit processome IPR006984; rRNA-processing protein UTP23 homolog UTP23 Bos taurus (Bovine) TR27969_c3_g1_i1 A4Q9F6 TTL13_MOUSE 2.00E-59 GO:0006464; GO:0016874 cellular protein modification process; ligase activity IPR004344; Tubulin polyglutamylase TTLL13 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 13) Ttll13 Mus musculus (Mouse) TR27973_c1_g1_i1 Q0CR95 PABP_ASPTN 3.00E-07 GO:0003723; GO:0005737; GO:0006397; GO:0051028; GO:0000166; GO:0005634; GO:0006417 RNA binding; cytoplasm; mRNA processing; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR012677; IPR006515; IPR002004; IPR000504; "Polyadenylate-binding protein, cytoplasmic and nuclear (PABP) (Poly(A)-binding protein) (Polyadenylate tail-binding protein)" pab1 ATEG_03789 Aspergillus terreus (strain NIH 2624 / FGSC A1156) TR27975_c1_g1_i1 Q8N7B6 PACRL_HUMAN 3.00E-40 IPR011989; IPR016024; IPR019399; PACRG-like protein PACRGL C4orf28 Homo sapiens (Human) TR27977_c0_g1_i3 P55567 Y4MH_RHISN 1.00E-30 GO:0003824 catalytic activity IPR006992; Uncharacterized protein y4mH NGR_a02510 y4mH Rhizobium sp. (strain NGR234) TR27979_c0_g1_i2 Q2VLH6 C163A_MOUSE 6.00E-15 GO:0006953; GO:0005576; GO:0016021; GO:0005886; GO:0005044 acute-phase response; extracellular region; integral to membrane; plasma membrane; scavenger receptor activity IPR001190; IPR017448; Scavenger receptor cysteine-rich type 1 protein M130 (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)] Cd163 M130 Mus musculus (Mouse) TR27979_c0_g1_i3 Q9NR16 C163B_HUMAN 1.00E-14 GO:0005576; GO:0016021; GO:0005886; GO:0005044 extracellular region; integral to membrane; plasma membrane; scavenger receptor activity IPR001190; IPR017448; Scavenger receptor cysteine-rich type 1 protein M160 (CD163 antigen-like 1) (CD antigen CD163b) CD163L1 CD163B M160 UNQ6434/PRO23202 Homo sapiens (Human) TR27984_c0_g1_i1 Q8CBA2 SLFN5_MOUSE 8.00E-24 GO:0005524; GO:0030154; GO:0005634 ATP binding; cell differentiation; nucleus IPR007421; IPR018647; IPR027417; Schlafen family member 5 Slfn5 Mus musculus (Mouse) TR27984_c3_g1_i1 Q08AF3 SLFN5_HUMAN 2.00E-15 GO:0005524; GO:0030154; GO:0005634 ATP binding; cell differentiation; nucleus IPR007421; IPR018647; IPR027417; Schlafen family member 5 SLFN5 Homo sapiens (Human) TR27986_c1_g1_i1 Q9ES30 C1QT3_MOUSE 6.00E-08 GO:0005581; GO:0005615; GO:0042593; GO:0042802; GO:0045721; GO:0070374; GO:0070165; GO:0050715; GO:0051897; GO:0051259 collagen; extracellular space; glucose homeostasis; identical protein binding; negative regulation of gluconeogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of adiponectin secretion; positive regulation of cytokine secretion; positive regulation of protein kinase B signaling cascade; protein oligomerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1qtnf3 Cors26 Ctrp3 Mus musculus (Mouse) TR27986_c1_g1_i2 P83425 HIP_MYTED 2.00E-11 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR27988_c0_g1_i1 Q8N967 LRTM2_HUMAN 3.00E-13 GO:0016021 integral to membrane IPR000483; IPR001611; IPR003591; IPR000372; Leucine-rich repeat and transmembrane domain-containing protein 2 LRTM2 Homo sapiens (Human) TR27988_c1_g1_i1 O93233 PLIB_GLOBS 1.00E-09 GO:0019834 phospholipase A2 inhibitor activity IPR000483; IPR001611; IPR003591; Phospholipase A2 inhibitor (beta-PLI) Gloydius brevicaudus siniticus (Chinese mamushi) (Agkistrodon blomhoffii siniticus) TR27991_c0_g1_i1 Q9NHX0 RBX1B_DROME 1.00E-21 GO:0019005; GO:0006919; GO:0008283; GO:0005737; GO:0019915; GO:0005634; GO:0030317; GO:0004842; GO:0008270 SCF ubiquitin ligase complex; activation of cysteine-type endopeptidase activity involved in apoptotic process; cell proliferation; cytoplasm; lipid storage; nucleus; sperm motility; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; IPR024766; Protein modification; protein ubiquitination. RING-box protein 1B (Regulator of cullins 1b) Roc1b ROC2 CG16988 Drosophila melanogaster (Fruit fly) TR27991_c0_g1_i2 Q9UBF6 RBX2_HUMAN 1.00E-49 GO:0031466; GO:0019788; GO:0005507; GO:0005737; GO:0008631; GO:0043066; GO:0005634; GO:0045116; GO:0016567; GO:0051775; GO:0008270 Q96Q27; Q9Y6K9; P12504 Cul5-RING ubiquitin ligase complex; NEDD8 ligase activity; copper ion binding; cytoplasm; intrinsic apoptotic signaling pathway in response to oxidative stress; negative regulation of apoptotic process; nucleus; protein neddylation; protein ubiquitination; response to redox state; zinc ion binding IPR001841; IPR013083; IPR024766; Protein modification; protein ubiquitination. RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein) RNF7 RBX2 ROC2 SAG Homo sapiens (Human) TR27991_c0_g1_i3 Q9LQM2 ATL81_ARATH 1.00E-06 GO:0016021; GO:0016567; GO:0008270 integral to membrane; protein ubiquitination; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. RING-H2 finger protein ATL81 ATL81 At1g32361 F27G20.11 F5D14.13 Arabidopsis thaliana (Mouse-ear cress) TR27993_c2_g1_i1 Q55DQ0 DCD3B_DICDI 6.00E-08 GO:0006672; GO:0016811; GO:0016021 "ceramide metabolic process; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; integral to membrane" IPR008901; Putative alkaline ceramidase dcd3B (EC 3.5.1.-) dcd3B DDB_G0269574 Dictyostelium discoideum (Slime mold) TR27993_c4_g1_i1 Q9D099 ACER3_MOUSE 9.00E-32 GO:0006672; GO:0030173; GO:0030176; GO:0070774; GO:0071602; GO:0008284; GO:0046512 ceramide metabolic process; integral to Golgi membrane; integral to endoplasmic reticulum membrane; phytoceramidase activity; phytosphingosine biosynthetic process; positive regulation of cell proliferation; sphingosine biosynthetic process IPR008901; Alkaline ceramidase 3 (AlkCDase 3) (Alkaline CDase 3) (EC 3.5.1.-) (Alkaline phytoceramidase) (aPHC) Acer3 Aphc Phca Mus musculus (Mouse) TR27993_c4_g1_i2 Q9D099 ACER3_MOUSE 8.00E-19 GO:0006672; GO:0030173; GO:0030176; GO:0070774; GO:0071602; GO:0008284; GO:0046512 ceramide metabolic process; integral to Golgi membrane; integral to endoplasmic reticulum membrane; phytoceramidase activity; phytosphingosine biosynthetic process; positive regulation of cell proliferation; sphingosine biosynthetic process IPR008901; Alkaline ceramidase 3 (AlkCDase 3) (Alkaline CDase 3) (EC 3.5.1.-) (Alkaline phytoceramidase) (aPHC) Acer3 Aphc Phca Mus musculus (Mouse) TR27995_c0_g1_i1 Q68FT3 PYRD2_RAT 1.00E-96 GO:0016491 oxidoreductase activity Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (EC 1.-.-.-) Pyroxd2 Rattus norvegicus (Rat) TR27996_c2_g1_i1 Q19546 WRN_CAEEL 4.00E-16 GO:0005524; GO:0043140; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0005694; GO:0008340; GO:0040007; GO:0005654; GO:0010212 ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA binding; DNA recombination; DNA repair; DNA replication; chromosome; determination of adult lifespan; growth; nucleoplasm; response to ionizing radiation IPR011545; IPR004589; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR018982; IPR011991; Probable Werner syndrome ATP-dependent helicase homolog 1 (EC 3.6.4.12) wrn-1 F18C5.2 Caenorhabditis elegans TR27998_c0_g2_i1 Q8Q0U0 Y045_METMA 8.00E-31 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR27998_c0_g2_i2 Q54KA7 SECG_DICDI 3.00E-23 GO:0005086; GO:0031589; GO:0006935; GO:0005829; GO:0005764; GO:0005543; GO:0032012 ARF guanyl-nucleotide exchange factor activity; cell-substrate adhesion; chemotaxis; cytosol; lysosome; phospholipid binding; regulation of ARF protein signal transduction IPR002110; IPR020683; IPR011993; IPR001849; IPR023394; IPR000904; "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) TR28005_c4_g1_i1 B2TLZ8 DNAJ_CLOBB 3.00E-09 GO:0005524; GO:0006260; GO:0005737; GO:0006457; GO:0009408; GO:0008270 ATP binding; DNA replication; cytoplasm; protein folding; response to heat; zinc ion binding IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; Chaperone protein DnaJ dnaJ CLL_A0892 Clostridium botulinum (strain Eklund 17B / Type B) TR28005_c4_g1_i2 Q8EUM4 DNAJ_MYCPE 2.00E-12 GO:0005524; GO:0006260; GO:0005737; GO:0006457; GO:0009408; GO:0008270 ATP binding; DNA replication; cytoplasm; protein folding; response to heat; zinc ion binding IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; Chaperone protein DnaJ dnaJ MYPE8970 Mycoplasma penetrans (strain HF-2) TR28005_c4_g1_i3 Q5R6H3 DJB14_PONAB 2.00E-12 GO:0016021 integral to membrane IPR001623; IPR018253; IPR015399; DnaJ homolog subfamily B member 14 DNAJB14 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR28006_c1_g1_i1 P17971 KCNAL_DROME 0 GO:0005250; GO:0030425; GO:0043204; GO:0051260; GO:0007268; GO:0008076 A-type (transient outward) potassium channel activity; dendrite; perikaryon; protein homooligomerization; synaptic transmission; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003975; IPR024587; IPR021645; IPR003131; IPR028325; Potassium voltage-gated channel protein Shal (Shaker cognate l) (Shal2) Shal SHAL2 CG9262 Drosophila melanogaster (Fruit fly) TR28009_c1_g2_i2 Q08828 ADCY1_HUMAN 2.00E-29 GO:0005524; GO:0007202; GO:0034199; GO:0007189; GO:0007193; GO:0007409; GO:0008294; GO:0005516; GO:0071377; GO:0007623; GO:0006112; GO:0007173; GO:0008543; GO:0045087; GO:0016021; GO:0035556; GO:0007616; GO:0046872; GO:0048011; GO:0005634; GO:0005886; GO:0042493; GO:0010226; GO:0007268; GO:0055085; GO:0006833 ATP binding; activation of phospholipase C activity; activation of protein kinase A activity; adenylate cyclase-activating G-protein coupled receptor signaling pathway; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; axonogenesis; calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding; cellular response to glucagon stimulus; circadian rhythm; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; integral to membrane; intracellular signal transduction; long-term memory; metal ion binding; neurotrophin TRK receptor signaling pathway; nucleus; plasma membrane; response to drug; response to lithium ion; synaptic transmission; transmembrane transport; water transport IPR001054; IPR018297; Adenylate cyclase type 1 (EC 4.6.1.1) (ATP pyrophosphate-lyase 1) (Adenylate cyclase type I) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) ADCY1 Homo sapiens (Human) TR28009_c4_g2_i1 Q03101 CYAG_DICDI 3.00E-12 GO:0005524; GO:0004016; GO:0016021; GO:0035556; GO:0016020; GO:0046872; GO:0046982; GO:0045859; GO:0006970; GO:0009847; GO:0030435 ATP binding; adenylate cyclase activity; integral to membrane; intracellular signal transduction; membrane; metal ion binding; protein heterodimerization activity; regulation of protein kinase activity; response to osmotic stress; spore germination; sporulation resulting in formation of a cellular spore IPR001054; IPR018297; IPR006189; "Adenylate cyclase, germination specific (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl cyclase)" acgA acg DDB_G0274569 Dictyostelium discoideum (Slime mold) TR28009_c4_g2_i2 O02298 GCY35_CAEEL 6.00E-11 GO:0005525; GO:0009454; GO:0007610; GO:0070025; GO:0005737; GO:0004383; GO:0020037; GO:0035556; GO:0046872; GO:0070026; GO:0019826; GO:0055093 GTP binding; aerotaxis; behavior; carbon monoxide binding; cytoplasm; guanylate cyclase activity; heme binding; intracellular signal transduction; metal ion binding; nitric oxide binding; oxygen sensor activity; response to hyperoxia IPR001054; IPR018297; IPR011645; IPR011644; IPR024096; Soluble guanylate cyclase gcy-35 (EC 4.6.1.2) gcy-35 T04D3.4 Caenorhabditis elegans TR28009_c4_g2_i3 Q08462 ADCY2_HUMAN 5.00E-35 GO:0005524; GO:0007202; GO:0034199; GO:0004016; GO:0008179; GO:0007189; GO:0007193; GO:0008294; GO:0071377; GO:0005737; GO:0030425; GO:0006112; GO:0007173; GO:0008543; GO:0045087; GO:0016021; GO:0035556; GO:0045121; GO:0046872; GO:0048011; GO:0005886; GO:0043234; GO:0046982; GO:0007268; GO:0055085; GO:0006833 ATP binding; activation of phospholipase C activity; activation of protein kinase A activity; adenylate cyclase activity; adenylate cyclase binding; adenylate cyclase-activating G-protein coupled receptor signaling pathway; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; calcium- and calmodulin-responsive adenylate cyclase activity; cellular response to glucagon stimulus; cytoplasm; dendrite; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; integral to membrane; intracellular signal transduction; membrane raft; metal ion binding; neurotrophin TRK receptor signaling pathway; plasma membrane; protein complex; protein heterodimerization activity; synaptic transmission; transmembrane transport; water transport IPR001054; IPR018297; IPR009398; Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2) ADCY2 KIAA1060 Homo sapiens (Human) TR2801_c0_g1_i1 Q6UX73 CP089_HUMAN 1.00E-09 GO:0005576 extracellular region UPF0764 protein C16orf89 C16orf89 UNQ904/PRO1925 Homo sapiens (Human) TR28011_c0_g1_i1 O75325 LRRN2_HUMAN 4.00E-29 GO:0007155; GO:0016021; GO:0004872; GO:0007165 cell adhesion; integral to membrane; receptor activity; signal transduction IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeat neuronal protein 2 (Glioma amplified on chromosome 1 protein) (Leucine-rich repeat neuronal protein 5) LRRN2 GAC1 LRRN5 UNQ256/PRO293 Homo sapiens (Human) TR28024_c1_g2_i1 A2AJ76 HMCN2_MOUSE 2.00E-07 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 Hmcn2 Mus musculus (Mouse) TR28024_c7_g2_i1 Q28260 VCAM1_CANFA 1.00E-07 GO:0016337; GO:0016021 cell-cell adhesion; integral to membrane IPR003987; IPR007110; IPR013783; IPR008424; IPR013098; IPR003599; IPR003598; IPR003989; Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (CD antigen CD106) VCAM1 Canis familiaris (Dog) (Canis lupus familiaris) TR28027_c1_g1_i1 Q32P85 DLRB2_BOVIN 1.00E-52 GO:0005868; GO:0005874; GO:0003774; GO:0006810 cytoplasmic dynein complex; microtubule; motor activity; transport IPR004942; IPR016561; "Dynein light chain roadblock-type 2 (Dynein light chain 2B, cytoplasmic)" DYNLRB2 DNLC2B Bos taurus (Bovine) TR28028_c2_g1_i2 Q9NXE8 CWC25_HUMAN 6.00E-12 IPR019339; IPR022209; Pre-mRNA-splicing factor CWC25 homolog (Coiled-coil domain-containing protein 49) (Spliceosome-associated protein homolog CWC25) CWC25 CCDC49 Homo sapiens (Human) TR28029_c0_g1_i1 A7Y2W8 SC6A9_XENLA 8.00E-47 GO:0005887; GO:0005328; GO:0005283 integral to plasma membrane; neurotransmitter:sodium symporter activity; sodium:amino acid symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9) slc6a9 glyt1 Xenopus laevis (African clawed frog) TR28029_c0_g1_i2 P23977 SC6A3_RAT 5.00E-39 GO:0021984; GO:0007568; GO:0030424; GO:0035240; GO:0042416; GO:0042420; GO:0015872; GO:0005330; GO:0008144; GO:0005887; GO:0007595; GO:0007626; GO:0043005; GO:0043025; GO:0005886; GO:0040018; GO:0060134; GO:0032403; GO:0042053; GO:0051591; GO:0042220; GO:0042493; GO:0045471; GO:0010039; GO:0035094; GO:0007608 adenohypophysis development; aging; axon; dopamine binding; dopamine biosynthetic process; dopamine catabolic process; dopamine transport; dopamine:sodium symporter activity; drug binding; integral to plasma membrane; lactation; locomotory behavior; neuron projection; neuronal cell body; plasma membrane; positive regulation of multicellular organism growth; prepulse inhibition; protein complex binding; regulation of dopamine metabolic process; response to cAMP; response to cocaine; response to drug; response to ethanol; response to iron ion; response to nicotine; sensory perception of smell IPR000175; IPR002436; Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3) Slc6a3 Rattus norvegicus (Rat) TR28030_c2_g3_i1 Q6DJ83 CADM2_XENTR 8.00E-09 GO:0016021 integral to membrane IPR013162; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; IPR003585; Cell adhesion molecule 2 (Immunoglobulin superfamily member 4D) (IgSF4D) cadm2 igsf4d Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28030_c2_g4_i1 Q5G265 NETR_SAGLB 1.00E-18 GO:0030424; GO:0006887; GO:0005576; GO:0005886; GO:0006508; GO:0005044; GO:0004252 axon; exocytosis; extracellular region; plasma membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR001190; IPR017448; IPR009003; Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Saguinus labiatus (Red-chested mustached tamarin) TR28035_c1_g1_i1 Q9NB71 HIW_DROME 1.00E-07 GO:0030509; GO:0007628; GO:0006914; GO:0016023; GO:0040011; GO:0030514; GO:0045886; GO:0005634; GO:0005886; GO:0050808; GO:0006351; GO:0004842; GO:0008270 "BMP signaling pathway; adult walking behavior; autophagy; cytoplasmic membrane-bounded vesicle; locomotion; negative regulation of BMP signaling pathway; negative regulation of synaptic growth at neuromuscular junction; nucleus; plasma membrane; synapse organization; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR004939; IPR017868; IPR008979; IPR027047; IPR013783; IPR014756; IPR012983; IPR009091; IPR000408; IPR003646; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase highwire (EC 6.3.2.-) (Protein pam/highwire/rpm-1) hiw CG32592 Drosophila melanogaster (Fruit fly) TR28035_c2_g1_i1 Q80VI1 TRI56_MOUSE 5.00E-19 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) TR28036_c1_g1_i1 Q91WC9 DGLB_MOUSE 9.00E-60 GO:0019369; GO:0016021; GO:0016042; GO:0046872; GO:0007405; GO:0042136; GO:0005886; GO:0004806 arachidonic acid metabolic process; integral to membrane; lipid catabolic process; metal ion binding; neuroblast proliferation; neurotransmitter biosynthetic process; plasma membrane; triglyceride lipase activity IPR002921; Sn1-specific diacylglycerol lipase beta (DGL-beta) (EC 3.1.1.-) Daglb Mus musculus (Mouse) TR28040_c0_g1_i1 Q9NSN8 SNTG1_HUMAN 3.00E-74 GO:0007154; GO:0005737; GO:0005856; GO:0005634; GO:0005543; GO:0032587; GO:0016013 cell communication; cytoplasm; cytoskeleton; nucleus; phospholipid binding; ruffle membrane; syntrophin complex IPR001478; IPR011993; IPR001849; IPR015482; IPR015483; Gamma-1-syntrophin (G1SYN) (Syntrophin-4) (SYN4) SNTG1 Homo sapiens (Human) TR28040_c0_g2_i1 Q9NSN8 SNTG1_HUMAN 1.00E-13 GO:0007154; GO:0005737; GO:0005856; GO:0005634; GO:0005543; GO:0032587; GO:0016013 cell communication; cytoplasm; cytoskeleton; nucleus; phospholipid binding; ruffle membrane; syntrophin complex IPR001478; IPR011993; IPR001849; IPR015482; IPR015483; Gamma-1-syntrophin (G1SYN) (Syntrophin-4) (SYN4) SNTG1 Homo sapiens (Human) TR28044_c0_g1_i1 Q08AX9 K1841_XENLA 5.00E-74 IPR021777; Uncharacterized protein KIAA1841 homolog Xenopus laevis (African clawed frog) TR28044_c0_g1_i2 Q08AX9 K1841_XENLA 7.00E-70 IPR021777; Uncharacterized protein KIAA1841 homolog Xenopus laevis (African clawed frog) TR28046_c1_g2_i1 P21128 ENDOU_HUMAN 6.00E-07 GO:0003723; GO:0005737; GO:0004521; GO:0005615; GO:0007565; GO:0008083; GO:0006955; GO:0030145; GO:0005886; GO:0030247; GO:0006508; GO:0005044; GO:0008236 RNA binding; cytoplasm; endoribonuclease activity; extracellular space; female pregnancy; growth factor activity; immune response; manganese ion binding; plasma membrane; polysaccharide binding; proteolysis; scavenger receptor activity; serine-type peptidase activity IPR018998; IPR020436; IPR001212; Poly(U)-specific endoribonuclease (EC 3.1.-.-) (Placental protein 11) (PP11) (Protein endoU) (Uridylate-specific endoribonuclease) ENDOU Homo sapiens (Human) TR28047_c0_g1_i1 O88280 SLIT3_RAT 3.00E-11 GO:0007420; GO:0005509; GO:0030154; GO:0005576; GO:0016020; GO:0021510 brain development; calcium ion binding; cell differentiation; extracellular region; membrane; spinal cord development IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 3 protein (Slit-3) (Multiple epidermal growth factor-like domains protein 5) (Multiple EGF-like domains protein 5) Slit3 Megf5 Rattus norvegicus (Rat) TR28047_c0_g1_i2 O75093 SLIT1_HUMAN 1.00E-14 GO:0048846; GO:0005509; GO:0005737; GO:0033563; GO:0040023; GO:0005615; GO:0048853; GO:0008045; GO:0050919; GO:0048843; GO:0051964; GO:0031290; GO:0021510; GO:0022028 axon extension involved in axon guidance; calcium ion binding; cytoplasm; dorsal/ventral axon guidance; establishment of nucleus localization; extracellular space; forebrain morphogenesis; motor neuron axon guidance; negative chemotaxis; negative regulation of axon extension involved in axon guidance; negative regulation of synapse assembly; retinal ganglion cell axon guidance; spinal cord development; tangential migration from the subventricular zone to the olfactory bulb IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR009030; IPR001791; IPR001611; IPR025875; IPR003591; IPR000372; Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4) SLIT1 KIAA0813 MEGF4 SLIL1 Homo sapiens (Human) TR28047_c0_g1_i3 Q13591 SEM5A_HUMAN 5.00E-08 GO:0007411; GO:0008046; GO:0007155; GO:0007267; GO:0016021; GO:0001569; GO:0005886 axon guidance; axon guidance receptor activity; cell adhesion; cell-cell signaling; integral to membrane; patterning of blood vessels; plasma membrane IPR016201; IPR002165; IPR001627; IPR027231; IPR000884; IPR015943; Semaphorin-5A (Semaphorin-F) (Sema F) SEMA5A SEMAF Homo sapiens (Human) TR28047_c0_g1_i4 O75093 SLIT1_HUMAN 4.00E-15 GO:0048846; GO:0005509; GO:0005737; GO:0033563; GO:0040023; GO:0005615; GO:0048853; GO:0008045; GO:0050919; GO:0048843; GO:0051964; GO:0031290; GO:0021510; GO:0022028 axon extension involved in axon guidance; calcium ion binding; cytoplasm; dorsal/ventral axon guidance; establishment of nucleus localization; extracellular space; forebrain morphogenesis; motor neuron axon guidance; negative chemotaxis; negative regulation of axon extension involved in axon guidance; negative regulation of synapse assembly; retinal ganglion cell axon guidance; spinal cord development; tangential migration from the subventricular zone to the olfactory bulb IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR009030; IPR001791; IPR001611; IPR025875; IPR003591; IPR000372; Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4) SLIT1 KIAA0813 MEGF4 SLIL1 Homo sapiens (Human) TR28048_c0_g2_i4 Q5R9E6 ATP5S_PONAB 4.00E-37 GO:0006754; GO:0046872; GO:0005743; GO:0015992; GO:0045263 "ATP biosynthetic process; metal ion binding; mitochondrial inner membrane; proton transport; proton-transporting ATP synthase complex, coupling factor F(o)" IPR026063; "ATP synthase subunit s, mitochondrial (ATP synthase-coupling factor B) (FB) (Mitochondrial ATP synthase regulatory component factor B)" ATP5S Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR28048_c0_g2_i6 Q5I0I4 AT5SL_RAT 1.00E-11 IPR026303; ATP synthase subunit s-like protein Atp5sl Rattus norvegicus (Rat) TR28049_c0_g1_i2 P86729 EPDR2_HALAI 5.00E-07 GO:0005509; GO:0007160; GO:0005576 calcium ion binding; cell-matrix adhesion; extracellular region IPR001299; Ependymin-related protein 2 Haliotis asinina (Donkey's ear abalone) (Ass's ear abalone) TR28051_c0_g1_i1 Q7Z0T3 TEMPT_APLCA 4.00E-15 GO:0005576 extracellular region Temptin Aplysia californica (California sea hare) TR28052_c1_g1_i1 Q9ERF3 WDR61_MOUSE 1.00E-07 GO:0016593; GO:0055087; GO:0016055; GO:0080182; GO:0045638; GO:0051571; GO:2001162; GO:0032968; GO:0045944; GO:0006351; GO:0035327 "Cdc73/Paf1 complex; Ski complex; Wnt receptor signaling pathway; histone H3-K4 trimethylation; negative regulation of myeloid cell differentiation; positive regulation of histone H3-K4 methylation; positive regulation of histone H3-K79 methylation; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; transcriptionally active chromatin" IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 61 (Meiotic recombination REC14 protein homolog) Wdr61 Mus musculus (Mouse) TR28052_c2_g1_i1 Q9D180 WDR65_MOUSE 3.00E-134 IPR011047; IPR015943; IPR001680; IPR017986; WD repeat-containing protein 65 Wdr65 Mus musculus (Mouse) TR28053_c2_g1_i1 Q6UWP2 DHR11_HUMAN 1.00E-69 GO:0005576; GO:0016491 extracellular region; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Dehydrogenase/reductase SDR family member 11 (EC 1.-.-.-) DHRS11 UNQ836/PRO1774 Homo sapiens (Human) TR28053_c2_g1_i2 P39884 YDFG_DICNO 8.00E-15 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; Probable NADP-dependent dehydrogenase in aabA 3'region (EC 1.1.1.-) (ORFB) (Fragment) Dichelobacter nodosus (Bacteroides nodosus) TR28053_c2_g2_i1 Q71R50 DHR11_CHICK 8.00E-25 GO:0005576; GO:0016491 extracellular region; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Dehydrogenase/reductase SDR family member 11 (EC 1.-.-.-) DHRS11 Gallus gallus (Chicken) TR28055_c0_g1_i2 Q03567 YLD2_CAEEL 2.00E-79 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR011701; IPR020846; IPR016196; Uncharacterized transporter C38C10.2 C38C10.2 Caenorhabditis elegans TR28055_c1_g1_i2 P42205 GUDP_PSEPU 1.00E-08 GO:0016021; GO:0005886; GO:0055085; GO:0005215 integral to membrane; plasma membrane; transmembrane transport; transporter activity IPR004744; IPR011701; IPR020846; IPR016196; Probable glucarate transporter (D-glucarate permease) gudP Pseudomonas putida (Arthrobacter siderocapsulatus) TR28056_c3_g1_i1 Q06807 TIE2_BOVIN 2.00E-07 GO:0005524; GO:0048014; GO:0005884; GO:0016324; GO:0009925; GO:0009986; GO:0005911; GO:0005737; GO:0001935; GO:0005576; GO:0005925; GO:0060347; GO:0005887; GO:0045121; GO:0005902; GO:0016525; GO:2000352; GO:0070374; GO:2000251; GO:0045766; GO:0010595; GO:0051894; GO:0043552; GO:0014068; GO:0051897; GO:0001934; GO:0046777; GO:0051259; GO:0004713; GO:0032878; GO:0002040; GO:0001725; GO:0034446; GO:0004714 ATP binding; Tie signaling pathway; actin filament; apical plasma membrane; basal plasma membrane; cell surface; cell-cell junction; cytoplasm; endothelial cell proliferation; extracellular region; focal adhesion; heart trabecula formation; integral to plasma membrane; membrane raft; microvillus; negative regulation of angiogenesis; negative regulation of endothelial cell apoptotic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of actin cytoskeleton reorganization; positive regulation of angiogenesis; positive regulation of endothelial cell migration; positive regulation of focal adhesion assembly; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of protein phosphorylation; protein autophosphorylation; protein oligomerization; protein tyrosine kinase activity; regulation of establishment or maintenance of cell polarity; sprouting angiogenesis; stress fiber; substrate adhesion-dependent cell spreading; transmembrane receptor protein tyrosine kinase activity IPR000742; IPR013032; IPR002049; IPR003961; IPR007110; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR018941; IPR008266; IPR020635; Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TIE-2) (CD antigen CD202b) TEK TIE-2 TIE2 Bos taurus (Bovine) TR28057_c0_g1_i1 P05934 CALM_STRPU 2.00E-17 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) (Fragment) Strongylocentrotus purpuratus (Purple sea urchin) TR28057_c0_g2_i1 O94739 CALM_PLEOS 1.00E-37 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) CMD1 Pleurotus ostreatus (Oyster mushroom) (White-rot fungus) TR28063_c0_g1_i1 Q5RL51 GSTCD_MOUSE 2.00E-103 IPR010987; IPR025714; Glutathione S-transferase C-terminal domain-containing protein Gstcd Mus musculus (Mouse) TR28063_c0_g1_i2 Q5RL51 GSTCD_MOUSE 2.00E-103 IPR010987; IPR025714; Glutathione S-transferase C-terminal domain-containing protein Gstcd Mus musculus (Mouse) TR28063_c0_g1_i3 A5PKL6 GSTCD_BOVIN 1.00E-102 IPR010987; IPR025714; Glutathione S-transferase C-terminal domain-containing protein GSTCD Bos taurus (Bovine) TR28066_c1_g1_i1 Q86VE9 SERC5_HUMAN 8.00E-58 GO:0005794; GO:0005789; GO:0016021; GO:0043209; GO:0042552; GO:0006658; GO:0008654; GO:0051347 Golgi apparatus; endoplasmic reticulum membrane; integral to membrane; myelin sheath; myelination; phosphatidylserine metabolic process; phospholipid biosynthetic process; positive regulation of transferase activity IPR005016; Serine incorporator 5 SERINC5 C5orf12 Homo sapiens (Human) TR28068_c0_g1_i1 Q9P035 HACD3_HUMAN 1.00E-40 GO:0005096; GO:0007249; GO:0016601; GO:0007266; GO:0007257; GO:0005789; GO:0006633; GO:0016021; GO:0016829 GTPase activator activity; I-kappaB kinase/NF-kappaB cascade; Rac protein signal transduction; Rho protein signal transduction; activation of JUN kinase activity; endoplasmic reticulum membrane; fatty acid biosynthetic process; integral to membrane; lyase activity IPR007052; IPR008978; IPR007482; Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 3) (HACD3) (Butyrate-induced protein 1) (B-ind1) (hB-ind1) (Protein tyrosine phosphatase-like protein PTPLAD1) (Protein-tyrosine phosphatase-like A domain-containing protein 1) PTPLAD1 BIND1 HACD3 Homo sapiens (Human) TR28074_c0_g1_i1 P42297 YXIE_BACSU 1.00E-08 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein YxiE (USP YxiE) yxiE BSU39250 N17E Bacillus subtilis (strain 168) TR28076_c3_g1_i1 P86860 PSM_MYTCA 0 GO:0005576 extracellular region IPR008985; IPR013320; Shell matrix protein (Fragment) Mytilus californianus (California mussel) TR28076_c4_g1_i1 C7G0B5 PIF_PINFU 1.00E-07 GO:0008061; GO:0006030; GO:0005578 chitin binding; chitin metabolic process; proteinaceous extracellular matrix IPR002557; IPR002035; Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] Pinctada fucata (Pearl oyster) TR28077_c3_g1_i1 Q9P2D7 DYH1_HUMAN 2.00E-13 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018; GO:0009612 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement; response to mechanical stimulus IPR011704; IPR026983; IPR026975; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 1, axonemal (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1) (Heat shock regulated protein 1) (HSRF-1) (hDHC7)" DNAH1 DHC7 DNAHC1 KIAA1410 Homo sapiens (Human) TR28085_c0_g1_i1 A3KGZ2 OGFD2_DANRE 2.00E-129 GO:0031418; GO:0005506; GO:0016706 "L-ascorbic acid binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" IPR005123; IPR006620; 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (EC 1.14.11.-) ogfod2 si:dkey-21k4.1 zgc:158437 Danio rerio (Zebrafish) (Brachydanio rerio) TR28088_c2_g1_i1 Q6VY07 PACS1_HUMAN 2.00E-46 GO:0030137; GO:0005829; GO:0019048; GO:0000042; GO:0072661; GO:0050690; GO:0016032 P67870; Q9NZ52; P11717 COPI-coated vesicle; cytosol; modulation by virus of host morphology or physiology; protein targeting to Golgi; protein targeting to plasma membrane; regulation of defense response to virus by virus; viral process IPR019381; Phosphofurin acidic cluster sorting protein 1 (PACS-1) PACS1 KIAA1175 Homo sapiens (Human) TR28088_c5_g2_i1 Q3V3Q7 PACS2_MOUSE 8.00E-44 GO:0006915; GO:0005788; GO:0005739 apoptotic process; endoplasmic reticulum lumen; mitochondrion IPR019381; Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) Pacs2 Kiaa0602 Pacs1l Mus musculus (Mouse) TR28088_c5_g2_i2 Q3V3Q7 PACS2_MOUSE 2.00E-44 GO:0006915; GO:0005788; GO:0005739 apoptotic process; endoplasmic reticulum lumen; mitochondrion IPR019381; Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) Pacs2 Kiaa0602 Pacs1l Mus musculus (Mouse) TR28092_c13_g1_i1 Q5T5C0 STXB5_HUMAN 1.00E-13 GO:0005892; GO:0030054; GO:0030659; GO:0006887; GO:0045921; GO:0015031; GO:0008021; GO:0017075 acetylcholine-gated channel complex; cell junction; cytoplasmic vesicle membrane; exocytosis; positive regulation of exocytosis; protein transport; synaptic vesicle; syntaxin-1 binding IPR000664; IPR013905; IPR013577; IPR001388; IPR015943; IPR001680; IPR019775; IPR017986; Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) STXBP5 LLGL3 Homo sapiens (Human) TR28092_c2_g1_i1 Q3TJ91 L2GL2_MOUSE 4.00E-08 GO:0007049; GO:0051301; GO:0005737; GO:0006887 cell cycle; cell division; cytoplasm; exocytosis IPR000664; IPR013577; IPR015943; IPR001680; IPR019775; IPR017986; Lethal(2) giant larvae protein homolog 2 (Lethal giant larvae-like protein 2) Llgl2 Llglh2 Mus musculus (Mouse) TR28092_c6_g1_i1 Q5DQR4 STB5L_MOUSE 4.00E-64 GO:0005737; GO:0006887; GO:0042593; GO:0016021; GO:0046676; GO:0005886; GO:0015031; GO:0017157; GO:0019905 cytoplasm; exocytosis; glucose homeostasis; integral to membrane; negative regulation of insulin secretion; plasma membrane; protein transport; regulation of exocytosis; syntaxin binding IPR000664; IPR013905; IPR013577; IPR001388; IPR015943; IPR001680; IPR019775; IPR017986; Syntaxin-binding protein 5-like (Lethal(2) giant larvae protein homolog 4) (Tomosyn-2) Stxbp5l Llgl4 Mus musculus (Mouse) TR28092_c7_g1_i2 Q3SZ48 TM55A_BOVIN 2.00E-59 GO:0016787; GO:0016021; GO:0031902; GO:0005765 hydrolase activity; integral to membrane; late endosome membrane; lysosomal membrane IPR019178; "Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A)" TMEM55A Bos taurus (Bovine) TR28097_c4_g1_i1 Q5UPG5 YL093_MIMIV 1.00E-36 IPR002110; IPR020683; Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) TR28099_c0_g1_i1 Q5AQL0 PPIH_EMENI 5.00E-76 GO:0005634; GO:0003755; GO:0006457; GO:0000413 nucleus; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC 5.2.1.8) (Rotamase H) cyp3 AN9420 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR28099_c0_g1_i3 O43447 PPIH_HUMAN 1.00E-96 GO:0071001; GO:0046540; GO:0016018; GO:0005737; GO:0000398; GO:0016607; GO:0003755; GO:0045070; GO:0006461; GO:0006457; GO:0043021; GO:0005681 O43172 "U4/U6 snRNP; U4/U6 x U5 tri-snRNP complex; cyclosporin A binding; cytoplasm; mRNA splicing, via spliceosome; nuclear speck; peptidyl-prolyl cis-trans isomerase activity; positive regulation of viral genome replication; protein complex assembly; protein folding; ribonucleoprotein complex binding; spliceosomal complex" IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC 5.2.1.8) (Rotamase H) (Small nuclear ribonucleoprotein particle-specific cyclophilin H) (CypH) (U-snRNP-associated cyclophilin SnuCyp-20) (USA-CYP) PPIH CYP20 CYPH Homo sapiens (Human) TR28100_c1_g1_i1 P54276 MSH6_MOUSE 3.00E-40 GO:0043531; GO:0005524; GO:0008094; GO:0032301; GO:0003682; GO:0003684; GO:0008340; GO:0000400; GO:0032137; GO:0008630; GO:0045190; GO:0000287; GO:0043570; GO:0000710; GO:0035064; GO:0045910; GO:0000790; GO:0032357; GO:0051096; GO:0007131; GO:0009411; GO:0032138; GO:0032142; GO:0032143; GO:0016446 ADP binding; ATP binding; DNA-dependent ATPase activity; MutSalpha complex; chromatin binding; damaged DNA binding; determination of adult lifespan; four-way junction DNA binding; guanine/thymine mispair binding; intrinsic apoptotic signaling pathway in response to DNA damage; isotype switching; magnesium ion binding; maintenance of DNA repeat elements; meiotic mismatch repair; methylated histone residue binding; negative regulation of DNA recombination; nuclear chromatin; oxidized purine DNA binding; positive regulation of helicase activity; reciprocal meiotic recombination; response to UV; single base insertion or deletion binding; single guanine insertion binding; single thymine insertion binding; somatic hypermutation of immunoglobulin genes IPR017261; IPR015536; IPR007695; IPR000432; IPR007861; IPR007696; IPR016151; IPR007860; IPR027417; IPR000313; DNA mismatch repair protein Msh6 (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS-alpha 160 kDa subunit) (p160) Msh6 Gtmbp Mus musculus (Mouse) TR28100_c2_g2_i1 A4R0R0 MSH3_MAGO7 2.00E-15 GO:0005524; GO:0006298; GO:0030983; GO:0005634 ATP binding; mismatch repair; mismatched DNA binding; nucleus IPR007695; IPR000432; IPR007861; IPR007696; IPR016151; IPR007860; IPR027417; DNA mismatch repair protein MSH3 (MutS protein homolog 3) MSH3 MGG_09306 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) TR28100_c2_g2_i2 O74502 MSH6_SCHPO 3.00E-17 GO:0005524; GO:0005829; GO:0032137; GO:0043570; GO:0006298; GO:0005634 ATP binding; cytosol; guanine/thymine mispair binding; maintenance of DNA repeat elements; mismatch repair; nucleus IPR017261; IPR015536; IPR007695; IPR000432; IPR007861; IPR007696; IPR016151; IPR007860; IPR027417; DNA mismatch repair protein msh6 msh6 SPCC285.16c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR28100_c2_g2_i3 B2V1M2 MUTS_CLOBA 2.00E-08 GO:0005524; GO:0003684; GO:0006298; GO:0030983 ATP binding; damaged DNA binding; mismatch repair; mismatched DNA binding IPR005748; IPR007695; IPR000432; IPR007861; IPR007696; IPR016151; IPR007860; IPR027417; DNA mismatch repair protein MutS mutS CLH_1684 Clostridium botulinum (strain Alaska E43 / Type E3) TR28101_c0_g1_i1 Q8K0U4 HS12A_MOUSE 1.00E-35 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR28106_c2_g1_i1 D2X5V5 MSMB_LOLPE 9.00E-06 GO:0007610; GO:0005576 behavior; extracellular region Beta-microseminoprotein (Beta-MSP) Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR28109_c0_g2_i1 A5PKG6 UBE4A_BOVIN 5.00E-111 GO:0000151; GO:0006511; GO:0034450 ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-ubiquitin ligase activity IPR019474; IPR003613; IPR013083; Ubiquitin conjugation factor E4 A UBE4A Bos taurus (Bovine) TR28109_c2_g2_i1 Q9HE05 UFD2_SCHPO 4.00E-49 GO:0005737; GO:0005634; GO:0000151; GO:0006511; GO:0034450 cytoplasm; nucleus; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-ubiquitin ligase activity IPR019474; IPR003613; IPR013083; Protein modification; protein ubiquitination. Ubiquitin conjugation factor E4 (EC 6.3.2.-) (Ubiquitin fusion degradation protein 2) (UB fusion protein 2) ufd2 SPAC145.04 SPAC20H4.10 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR28110_c2_g1_i1 Q86UL3 GPAT4_HUMAN 1.00E-09 GO:0016024; GO:0006637; GO:0046339; GO:0005789; GO:0006631; GO:0002071; GO:0004366; GO:0016021; GO:0007595; GO:0006654; GO:0006656; GO:0040014; GO:0019432 CDP-diacylglycerol biosynthetic process; acyl-CoA metabolic process; diacylglycerol metabolic process; endoplasmic reticulum membrane; fatty acid metabolic process; glandular epithelial cell maturation; glycerol-3-phosphate O-acyltransferase activity; integral to membrane; lactation; phosphatidic acid biosynthetic process; phosphatidylcholine biosynthetic process; regulation of multicellular organism growth; triglyceride biosynthetic process IPR002123; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. Glycerol-3-phosphate acyltransferase 4 (GPAT4) (EC 2.3.1.15) (1-acylglycerol-3-phosphate O-acyltransferase 6) (1-AGP acyltransferase 6) (1-AGPAT 6) (Acyl-CoA:glycerol-3-phosphate acyltransferase 4) (Lysophosphatidic acid acyltransferase zeta) (LPAAT-zeta) AGPAT6 GPAT4 UNQ551/PRO1108 Homo sapiens (Human) TR28110_c2_g1_i2 Q0KHU5 PCAT1_DROME 3.00E-35 GO:0047184; GO:0005794; GO:0000139; GO:0005509; GO:0005783; GO:0005789; GO:0016021; GO:0008654 1-acylglycerophosphocholine O-acyltransferase activity; Golgi apparatus; Golgi membrane; calcium ion binding; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; phospholipid biosynthetic process IPR011992; IPR002048; IPR002123; Lipid metabolism; phospholipid metabolism. 1-acylglycerophosphocholine O-acyltransferase 1 (EC 2.3.1.23) (Acyltransferase-like 2) CG32699 Drosophila melanogaster (Fruit fly) TR28110_c4_g1_i1 Q8NF37 PCAT1_HUMAN 6.00E-40 GO:0047184; GO:0047192; GO:0005794; GO:0000139; GO:0005509; GO:0005789; GO:0016021; GO:0005811; GO:2001246; GO:0006654; GO:0036151; GO:0036148; GO:0045732; GO:0060041; GO:0043129; GO:0019432 1-acylglycerophosphocholine O-acyltransferase activity; 1-alkylglycerophosphocholine O-acetyltransferase activity; Golgi apparatus; Golgi membrane; calcium ion binding; endoplasmic reticulum membrane; integral to membrane; lipid particle; negative regulation of phosphatidylcholine biosynthetic process; phosphatidic acid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; positive regulation of protein catabolic process; retina development in camera-type eye; surfactant homeostasis; triglyceride biosynthetic process IPR011992; IPR002048; IPR002123; Lipid metabolism; phospholipid metabolism. Lysophosphatidylcholine acyltransferase 1 (LPC acyltransferase 1) (LPCAT-1) (LysoPC acyltransferase 1) (EC 2.3.1.23) (1-acylglycerophosphocholine O-acyltransferase) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 2) (Phosphonoformate immuno-associated protein 3) LPCAT1 AYTL2 PFAAP3 Homo sapiens (Human) TR28110_c6_g2_i2 Q502J0 PCAT2_DANRE 1.00E-34 GO:0003841; GO:0047184; GO:0047192; GO:0000139; GO:0005509; GO:0005789; GO:0016021; GO:0005811; GO:0008654 1-acylglycerol-3-phosphate O-acyltransferase activity; 1-acylglycerophosphocholine O-acyltransferase activity; 1-alkylglycerophosphocholine O-acetyltransferase activity; Golgi membrane; calcium ion binding; endoplasmic reticulum membrane; integral to membrane; lipid particle; phospholipid biosynthetic process IPR011992; IPR018247; IPR002048; IPR002123; Lipid metabolism; phospholipid metabolism. Lysophosphatidylcholine acyltransferase 2 (LPC acyltransferase 2) (LPCAT-2) (LysoPC acyltransferase 2) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase 11) (1-AGP acyltransferase 11) (1-AGPAT 11) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acyltransferase-like 1) lpcat2 aytl1 zgc:112165 Danio rerio (Zebrafish) (Brachydanio rerio) TR28115_c0_g1_i2 Q8N0W5 IQCK_HUMAN 1.00E-20 IQ domain-containing protein K IQCK Homo sapiens (Human) TR28122_c1_g1_i1 Q60GI5 GA45A_FELCA 9.00E-21 GO:0007050; GO:0071479; GO:0071260; GO:0007098; GO:0001047; GO:0006469; GO:0005634; GO:2000379; GO:0042770 cell cycle arrest; cellular response to ionizing radiation; cellular response to mechanical stimulus; centrosome cycle; core promoter binding; negative regulation of protein kinase activity; nucleus; positive regulation of reactive oxygen species metabolic process; signal transduction in response to DNA damage IPR024824; IPR004038; Growth arrest and DNA damage-inducible protein GADD45 alpha GADD45A Felis catus (Cat) (Felis silvestris catus) TR28122_c1_g1_i2 Q5E9A5 GA45B_BOVIN 4.00E-17 GO:0000186; GO:0006915; GO:0030154; GO:0007275; GO:0006469; GO:0005634; GO:0051726; GO:0006950 activation of MAPKK activity; apoptotic process; cell differentiation; multicellular organismal development; negative regulation of protein kinase activity; nucleus; regulation of cell cycle; response to stress IPR024824; IPR004038; Growth arrest and DNA damage-inducible protein GADD45 beta GADD45B Bos taurus (Bovine) TR28124_c0_g1_i1 P70684 PGDH_CAVPO 5.00E-46 GO:0016404; GO:0070403; GO:0005737; GO:0097070; GO:0007565; GO:0045786; GO:0030728; GO:0007567; GO:0004957; GO:0006693; GO:0070493; GO:0007179 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; NAD+ binding; cytoplasm; ductus arteriosus closure; female pregnancy; negative regulation of cell cycle; ovulation; parturition; prostaglandin E receptor activity; prostaglandin metabolic process; thrombin receptor signaling pathway; transforming growth factor beta receptor signaling pathway IPR002198; IPR002347; IPR016040; IPR020904; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) HPGD PGDH1 Cavia porcellus (Guinea pig) TR28125_c0_g1_i4 P98074 ENTK_PIG 1.00E-08 GO:0016021; GO:0006508; GO:0005044; GO:0004252 integral to membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity IPR008985; IPR000859; IPR023415; IPR002172; IPR000998; IPR011163; IPR001254; IPR018114; IPR001314; IPR000082; IPR001190; IPR017448; IPR009003; Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic mini chain; Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain] TMPRSS15 ENTK PRSS7 Sus scrofa (Pig) TR28129_c0_g1_i1 Q5RB77 PDCL3_PONAB 2.00E-79 GO:0006915; GO:0005737; GO:0019048 apoptotic process; cytoplasm; modulation by virus of host morphology or physiology IPR006442; IPR024253; IPR012336; Phosducin-like protein 3 PDCL3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR28130_c0_g2_i1 Q99PV3 MKLN1_RAT 0 GO:0005737 cytoplasm IPR006595; IPR011043; IPR008979; IPR015915; IPR006594; IPR010565; Muskelin Mkln1 Msk Rattus norvegicus (Rat) TR28130_c0_g2_i2 Q93XW5 NSP5_ARATH 1.00E-07 GO:0005829; GO:0019762; GO:0080028 cytosol; glucosinolate catabolic process; nitrile biosynthetic process IPR015915; IPR006652; Nitrile-specifier protein 5 (AtNSP5) NSP5 At5g48180 MIF21.7 Arabidopsis thaliana (Mouse-ear cress) TR28132_c4_g1_i1 P30883 TBB4_XENLA 0 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR013838; IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta-4 chain tubb4 Xenopus laevis (African clawed frog) TR28132_c4_g1_i2 Q9D6T1 TBE_MOUSE 5.00E-46 GO:0005525; GO:0003924; GO:0051297; GO:0005874; GO:0000242; GO:0051258 GTP binding; GTPase activity; centrosome organization; microtubule; pericentriolar material; protein polymerization IPR004057; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin epsilon chain (Epsilon-tubulin) Tube1 Mus musculus (Mouse) TR28132_c5_g3_i1 P02556 TBB_LYTPI 3.00E-91 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; Tubulin beta chain (Beta-tubulin) (Fragment) Lytechinus pictus (Painted sea urchin) TR28133_c0_g1_i2 Q9QYT7 PIGQ_MOUSE 1.00E-57 GO:0006506; GO:0000506; GO:0016021; GO:0017176 GPI anchor biosynthetic process; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; integral to membrane; phosphatidylinositol N-acetylglucosaminyltransferase activity IPR007720; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (EC 2.4.1.198) (MGpi1p) (N-acetylglucosamyl transferase component GPI1) (Phosphatidylinositol-glycan biosynthesis class Q protein) (PIG-Q) Pigq Gpi1h Mgpi1 Mus musculus (Mouse) TR28134_c1_g1_i1 Q9H3H1 MOD5_HUMAN 5.00E-134 GO:0005524; GO:0046872; GO:0005739; GO:0052381; GO:0008033 ATP binding; metal ion binding; mitochondrion; tRNA dimethylallyltransferase activity; tRNA processing IPR002627; IPR027417; IPR018022; IPR022755; "tRNA dimethylallyltransferase, mitochondrial (EC 2.5.1.75) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPPT) (hGRO1) (tRNA isopentenyltransferase) (IPTase)" TRIT1 IPT MOD5 Homo sapiens (Human) TR28135_c2_g3_i1 P81133 SIM1_HUMAN 1.00E-101 GO:0003677; GO:0030154; GO:0007399; GO:0005634; GO:0003700; GO:0004871; GO:0006351; GO:0001657 "DNA binding; cell differentiation; nervous system development; nucleus; sequence-specific DNA binding transcription factor activity; signal transducer activity; transcription, DNA-dependent; ureteric bud development" IPR011598; IPR001610; IPR000014; IPR013767; IPR013655; IPR010578; Single-minded homolog 1 (Class E basic helix-loop-helix protein 14) (bHLHe14) SIM1 BHLHE14 Homo sapiens (Human) TR28135_c5_g1_i1 P90953 HLH34_CAEEL 1.00E-10 GO:0003677; GO:0030154; GO:0007399; GO:0005634; GO:0006355; GO:0004871; GO:0006351 "DNA binding; cell differentiation; nervous system development; nucleus; regulation of transcription, DNA-dependent; signal transducer activity; transcription, DNA-dependent" IPR011598; IPR000014; IPR013767; Helix-loop-helix 34 hlh-34 T01D3.2 Caenorhabditis elegans TR28136_c0_g1_i2 P62321 RUXF_XENLA 3.00E-40 GO:0003723; GO:0008380; GO:0006397; GO:0005681 RNA binding; RNA splicing; mRNA processing; spliceosomal complex IPR010920; IPR001163; IPR006649; IPR016487; Small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) (SmF) snrpf Xenopus laevis (African clawed frog) TR28138_c0_g1_i1 Q9VKV5 LIN1_DROME 6.00E-28 GO:0022416; GO:0048749; GO:0005634; GO:0006909; GO:0045742; GO:0090303; GO:0035220; GO:0042060 chaeta development; compound eye development; nucleus; phagocytosis; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of wound healing; wing disc development; wound healing IPR003169; CD2 antigen cytoplasmic tail-binding protein 2 homolog (Protein hole-in-one) holn1 CG5198 Drosophila melanogaster (Fruit fly) TR28141_c0_g1_i1 Q8R5I0 KCNKF_RAT 2.00E-14 GO:0016021; GO:0005267; GO:0005244 integral to membrane; potassium channel activity; voltage-gated ion channel activity IPR003280; IPR013099; IPR003092; IPR008073; Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (rTASK-5) (TWIK-related acid-sensitive K(+) channel 5) Kcnk15 Task5 Rattus norvegicus (Rat) TR28141_c2_g1_i1 Q18120 TWK18_CAEEL 3.00E-09 GO:0016021; GO:0040011; GO:0016020; GO:0006936; GO:0015271 integral to membrane; locomotion; membrane; muscle contraction; outward rectifier potassium channel activity IPR003280; IPR013099; TWiK family of potassium channels protein 18 twk-18 C24A3.6 Caenorhabditis elegans TR28144_c0_g1_i2 Q28IG8 TPPC2_XENTR 1.00E-71 GO:0006888; GO:0005794; GO:0005783; GO:0048471 ER to Golgi vesicle-mediated transport; Golgi apparatus; endoplasmic reticulum; perinuclear region of cytoplasm IPR011012; IPR006722; Trafficking protein particle complex subunit 2 trappc2 TNeu113o05.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28144_c0_g1_i3 Q28IG8 TPPC2_XENTR 2.00E-71 GO:0006888; GO:0005794; GO:0005783; GO:0048471 ER to Golgi vesicle-mediated transport; Golgi apparatus; endoplasmic reticulum; perinuclear region of cytoplasm IPR011012; IPR006722; Trafficking protein particle complex subunit 2 trappc2 TNeu113o05.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28145_c0_g1_i1 Q8K1A0 METL5_MOUSE 4.00E-54 GO:0008168; GO:0003676 methyltransferase activity; nucleic acid binding IPR002052; IPR007848; Methyltransferase-like protein 5 (EC 2.1.1.-) Mettl5 Mus musculus (Mouse) TR28146_c0_g1_i1 Q9Y3E5 PTH2_HUMAN 6.00E-51 GO:0004045; GO:0006915; GO:0005829; GO:0005739; GO:2000811; GO:0010629; GO:2000210 Q08117; Q05397 aminoacyl-tRNA hydrolase activity; apoptotic process; cytosol; mitochondrion; negative regulation of anoikis; negative regulation of gene expression; positive regulation of anoikis IPR023476; IPR002833; "Peptidyl-tRNA hydrolase 2, mitochondrial (PTH 2) (EC 3.1.1.29) (Bcl-2 inhibitor of transcription 1)" PTRH2 BIT1 PTH2 CGI-147 Homo sapiens (Human) TR28146_c0_g1_i3 Q5JDB8 PTH_PYRKO 2.00E-36 GO:0004045; GO:0005737 aminoacyl-tRNA hydrolase activity; cytoplasm IPR023476; IPR002833; Peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29) pth TK2300 Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) TR28147_c1_g1_i1 Q6DF55 VASN_XENTR 5.00E-07 GO:0016021 integral to membrane IPR000483; IPR000742; IPR013032; IPR001611; IPR003591; IPR000372; Vasorin vasn Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28147_c2_g2_i1 O43300 LRRT2_HUMAN 1.00E-07 GO:0030054; GO:0060076; GO:0016021; GO:0045211; GO:0050808 cell junction; excitatory synapse; integral to membrane; postsynaptic membrane; synapse organization IPR001611; IPR025875; IPR003591; IPR000372; Leucine-rich repeat transmembrane neuronal protein 2 (Leucine-rich repeat neuronal 2 protein) LRRTM2 KIAA0416 LRRN2 Homo sapiens (Human) TR28147_c2_g3_i1 Q9BXB1 LGR4_HUMAN 2.00E-08 GO:0004930; GO:0030282; GO:0046849; GO:0061290; GO:0072202; GO:0050673; GO:0045087; GO:0005887; GO:0030539; GO:0072224; GO:0072282; GO:0050710; GO:0034122; GO:0045892; GO:0001649; GO:0090190; GO:0090263; GO:0045893; GO:0007283 "G-protein coupled receptor activity; bone mineralization; bone remodeling; canonical Wnt receptor signaling pathway involved in metanephric kidney development; cell differentiation involved in metanephros development; epithelial cell proliferation; innate immune response; integral to plasma membrane; male genitalia development; metanephric glomerulus development; metanephric nephron tubule morphogenesis; negative regulation of cytokine secretion; negative regulation of toll-like receptor signaling pathway; negative regulation of transcription, DNA-dependent; osteoblast differentiation; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of transcription, DNA-dependent; spermatogenesis" IPR000276; IPR017452; IPR002131; IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48) LGR4 GPR48 Homo sapiens (Human) TR28150_c0_g1_i1 Q54HH2 SRR_DICDI 6.00E-57 GO:0005524; GO:0008721; GO:0070179; GO:0003941; GO:0006563; GO:0005737; GO:0000287; GO:0018249; GO:0030170; GO:0030378 ATP binding; D-serine ammonia-lyase activity; D-serine biosynthetic process; L-serine ammonia-lyase activity; L-serine metabolic process; cytoplasm; magnesium ion binding; protein dehydration; pyridoxal phosphate binding; serine racemase activity IPR001926; Probable serine racemase (EC 4.3.1.17) (EC 4.3.1.18) (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (L-serine ammonia-lyase) (L-serine dehydratase) srr DDB_G0289463 Dictyostelium discoideum (Slime mold) TR28150_c0_g2_i1 Q54HH2 SRR_DICDI 5.00E-27 GO:0005524; GO:0008721; GO:0070179; GO:0003941; GO:0006563; GO:0005737; GO:0000287; GO:0018249; GO:0030170; GO:0030378 ATP binding; D-serine ammonia-lyase activity; D-serine biosynthetic process; L-serine ammonia-lyase activity; L-serine metabolic process; cytoplasm; magnesium ion binding; protein dehydration; pyridoxal phosphate binding; serine racemase activity IPR001926; Probable serine racemase (EC 4.3.1.17) (EC 4.3.1.18) (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (L-serine ammonia-lyase) (L-serine dehydratase) srr DDB_G0289463 Dictyostelium discoideum (Slime mold) TR28151_c4_g1_i2 Q14590 ZN235_HUMAN 2.00E-54 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) TR28152_c1_g1_i1 Q55FJ2 WDR91_DICDI 1.00E-06 IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 91 homolog wdr91 DDB_G0268084 Dictyostelium discoideum (Slime mold) TR28152_c2_g1_i1 Q5R629 ARMC9_PONAB 6.00E-101 IPR011989; IPR016024; IPR006594; LisH domain-containing protein ARMC9 ARMC9 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR28152_c2_g1_i2 Q2KI89 ARMC9_BOVIN 2.00E-98 IPR011989; IPR016024; IPR006594; LisH domain-containing protein ARMC9 ARMC9 Bos taurus (Bovine) TR28152_c2_g4_i1 A0JMA8 ARMC9_XENTR 2.00E-32 IPR011989; IPR016024; IPR006594; LisH domain-containing protein ARMC9 armc9 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28155_c2_g1_i1 P17105 IP3KA_RAT 1.00E-74 GO:0005524; GO:0048365; GO:0030036; GO:0004683; GO:0043197; GO:0097062; GO:0006020; GO:0008440; GO:0061003; GO:0048167 "ATP binding; Rac GTPase binding; actin cytoskeleton organization; calmodulin-dependent protein kinase activity; dendritic spine; dendritic spine maintenance; inositol metabolic process; inositol-1,4,5-trisphosphate 3-kinase activity; positive regulation of dendritic spine morphogenesis; regulation of synaptic plasticity" IPR005522; "Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A)" Itpka Rattus norvegicus (Rat) TR28155_c2_g1_i3 P17105 IP3KA_RAT 8.00E-75 GO:0005524; GO:0048365; GO:0030036; GO:0004683; GO:0043197; GO:0097062; GO:0006020; GO:0008440; GO:0061003; GO:0048167 "ATP binding; Rac GTPase binding; actin cytoskeleton organization; calmodulin-dependent protein kinase activity; dendritic spine; dendritic spine maintenance; inositol metabolic process; inositol-1,4,5-trisphosphate 3-kinase activity; positive regulation of dendritic spine morphogenesis; regulation of synaptic plasticity" IPR005522; "Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A)" Itpka Rattus norvegicus (Rat) TR28158_c0_g1_i1 Q86FP7 RS23_DERVA 4.00E-86 GO:0015935; GO:0003735; GO:0006412 small ribosomal subunit; structural constituent of ribosome; translation IPR012340; IPR006032; IPR005680; 40S ribosomal protein S23 RpS23 Dermacentor variabilis (American dog tick) TR28159_c2_g1_i2 Q7K4B6 TMTC3_DROME 4.00E-21 GO:0016021 integral to membrane IPR013618; IPR013026; IPR011990; IPR019734; Transmembrane and TPR repeat-containing protein CG4050 CG4050 Drosophila melanogaster (Fruit fly) TR28159_c2_g1_i3 Q8IUR5 TMTC1_HUMAN 1.00E-64 GO:0016021; GO:0005739 integral to membrane; mitochondrion IPR013618; IPR013026; IPR011990; IPR001440; IPR019734; Transmembrane and TPR repeat-containing protein 1 TMTC1 ARG99 Homo sapiens (Human) TR28159_c2_g2_i1 Q3UV71 TMTC1_MOUSE 2.00E-13 GO:0016021; GO:0005739 integral to membrane; mitochondrion IPR013618; IPR013026; IPR011990; IPR013105; IPR019734; Transmembrane and TPR repeat-containing protein 1 Tmtc1 Mus musculus (Mouse) TR28161_c0_g1_i1 Q6P823 H33_XENTR 2.00E-89 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR000164; Histone H3.3 TGas113e22.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28163_c0_g1_i1 Q8NBH2 KY_HUMAN 7.00E-09 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) KY Homo sapiens (Human) TR28165_c1_g1_i2 Q7XK25 PCH2_ORYSJ 6.00E-57 GO:0005524; GO:0007126; GO:0017111 ATP binding; meiosis; nucleoside-triphosphatase activity IPR003593; IPR003959; IPR003960; IPR001270; IPR027417; Pachytene checkpoint protein 2 homolog Os04g0479000 LOC_Os04g40290 OsJ_15194 OSJNBa0044K18.20 Oryza sativa subsp. japonica (Rice) TR28165_c2_g1_i2 Q15645 PCH2_HUMAN 1.00E-82 GO:0005524; GO:0006302; GO:0007144; GO:0001673; GO:0007141; GO:0017111; GO:0005634; GO:0001556; GO:0048477; GO:0007131; GO:0007286; GO:0007283; GO:0007130; GO:0003712; GO:0006366 Q969Q4; Q9H0W9; Q9BWC7; O95865; Q8IVS8; Q9BSH5; Q14847; Q96JB6; Q15013; Q9GZT8; O60260; P67775; Q6P9B6; Q96HA8 ATP binding; double-strand break repair; female meiosis I; male germ cell nucleus; male meiosis I; nucleoside-triphosphatase activity; nucleus; oocyte maturation; oogenesis; reciprocal meiotic recombination; spermatid development; spermatogenesis; synaptonemal complex assembly; transcription cofactor activity; transcription from RNA polymerase II promoter IPR003593; IPR003959; IPR003960; IPR001270; IPR027417; Pachytene checkpoint protein 2 homolog (Human papillomavirus type 16 E1 protein-binding protein) (16E1-BP) (HPV16 E1 protein-binding protein) (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13) (TR-interacting protein 13) (TRIP-13) TRIP13 PCH2 Homo sapiens (Human) TR28168_c0_g1_i1 P25712 NDUV3_BOVIN 8.00E-06 GO:0005747; GO:0055114 mitochondrial respiratory chain complex I; oxidation-reduction process IPR026193; "NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (Complex I-9kD) (CI-9kD) (NADH-ubiquinone oxidoreductase 9 kDa subunit)" NDUFV3 Bos taurus (Bovine) TR28174_c0_g1_i1 Q7ZY60 SAE2B_XENLA 2.00E-113 GO:0005524; GO:0019948; GO:0016874; GO:0046872; GO:0005634; GO:0016925 ATP binding; SUMO activating enzyme activity; ligase activity; metal ion binding; nucleus; protein sumoylation IPR009036; IPR016040; IPR000594; IPR028077; IPR023280; IPR000127; IPR019572; IPR018074; Protein modification; protein sumoylation. SUMO-activating enzyme subunit 2-B (EC 6.3.2.-) (Ubiquitin-like 1-activating enzyme E1B-B) (Ubiquitin-like modifier-activating enzyme 2-B) uba2-b sae2-b uble1b-b Xenopus laevis (African clawed frog) TR28174_c0_g2_i1 Q28GH3 SAE2_XENTR 0 GO:0005524; GO:0019948; GO:0005737; GO:0016874; GO:0046872; GO:0005634; GO:0016925 ATP binding; SUMO activating enzyme activity; cytoplasm; ligase activity; metal ion binding; nucleus; protein sumoylation IPR009036; IPR016040; IPR000594; IPR028077; IPR023280; IPR000127; IPR019572; IPR018074; Protein modification; protein sumoylation. SUMO-activating enzyme subunit 2 (EC 6.3.2.-) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) uba2 sae2 uble1b TEgg032e11.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28176_c2_g1_i1 P55013 S12A2_SQUAC 1.00E-152 GO:0015377; GO:0016021; GO:0006813; GO:0006814 cation:chloride symporter activity; integral to membrane; potassium ion transport; sodium ion transport IPR004841; IPR013612; IPR002443; IPR002444; IPR004842; Solute carrier family 12 member 2 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) (NKCC) (Na-K-CL symporter) SLC12A2 NKCC1 Squalus acanthias (Spiny dogfish) TR28178_c1_g2_i1 Q9EPZ8 RN103_RAT 7.00E-47 GO:0005783; GO:0005789; GO:0016021; GO:0004842; GO:0008270 endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF103 (EC 6.3.2.-) (Protein ADRG34) (RING finger protein 103) (Zinc finger protein 103) (Zfp-103) Rnf103 Zfp103 Rattus norvegicus (Rat) TR28180_c1_g1_i1 Q8C5S7 REC8_MOUSE 1.00E-13 GO:0007059; GO:0000778; GO:0000724; GO:0009566; GO:0000800; GO:0030999; GO:0001673; GO:0007141; GO:0034991; GO:0005654; GO:0001556; GO:0072520; GO:0007286 chromosome segregation; condensed nuclear chromosome kinetochore; double-strand break repair via homologous recombination; fertilization; lateral element; linear element assembly; male germ cell nucleus; male meiosis I; nuclear meiotic cohesin complex; nucleoplasm; oocyte maturation; seminiferous tubule development; spermatid development IPR023093; IPR006909; IPR006910; Meiotic recombination protein REC8 homolog (Cohesin Rec8p) Rec8 Mei8 Rec8L1 Mus musculus (Mouse) TR28183_c0_g1_i1 O43172 PRP4_HUMAN 0 GO:0015030; GO:0071001; GO:0000398; GO:0016607; GO:0005681 Q92917; O43447 "Cajal body; U4/U6 snRNP; mRNA splicing, via spliceosome; nuclear speck; spliceosomal complex" IPR020472; IPR027106; IPR014906; IPR003648; IPR015943; IPR001680; IPR019775; IPR017986; U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) PRPF4 PRP4 Homo sapiens (Human) TR28189_c10_g1_i1 P13944 COCA1_CHICK 4.00E-06 GO:0007155; GO:0005581 cell adhesion; collagen IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain (Fibrochimerin) COL12A1 Gallus gallus (Chicken) TR28189_c11_g1_i1 O00339 MATN2_HUMAN 1.00E-07 GO:0007411; GO:0005604; GO:0005509; GO:0031104; GO:0008347; GO:0001764; GO:0005578; GO:0048678 O15265; O00555 axon guidance; basement membrane; calcium ion binding; dendrite regeneration; glial cell migration; neuron migration; proteinaceous extracellular matrix; response to axon injury IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR009030; IPR019466; IPR002035; Matrilin-2 MATN2 UNQ193/PRO219 Homo sapiens (Human) TR28189_c5_g1_i1 P12111 CO6A3_HUMAN 3.00E-11 GO:0007411; GO:0007155; GO:0030574; GO:0005589; GO:0005788; GO:0022617; GO:0005615; GO:0007517; GO:0042383; GO:0004867 axon guidance; cell adhesion; collagen catabolic process; collagen type VI; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular space; muscle organ development; sarcolemma; serine-type endopeptidase inhibitor activity IPR008160; IPR003961; IPR013783; IPR002223; IPR020901; IPR002035; Collagen alpha-3(VI) chain COL6A3 Homo sapiens (Human) TR28189_c5_g1_i2 O35701 MATN3_MOUSE 9.00E-07 GO:0005509; GO:0005578 calcium ion binding; proteinaceous extracellular matrix IPR000742; IPR001881; IPR013032; IPR009030; IPR019466; IPR002035; Matrilin-3 Matn3 Mus musculus (Mouse) TR28189_c6_g1_i1 A2AX52 CO6A4_MOUSE 2.00E-14 GO:0007155; GO:0005581; GO:0005576; GO:0043234; GO:0070208 cell adhesion; collagen; extracellular region; protein complex; protein heterotrimerization IPR008160; IPR002035; Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) TR28189_c6_g2_i3 Q63870 CO7A1_MOUSE 1.00E-08 GO:0005604; GO:0007155; GO:0005581; GO:0004867 Itself basement membrane; cell adhesion; collagen; serine-type endopeptidase inhibitor activity IPR008160; IPR003961; IPR013783; IPR002223; IPR020901; IPR002035; Collagen alpha-1(VII) chain (Long-chain collagen) (LC collagen) Col7a1 Mus musculus (Mouse) TR28190_c0_g1_i1 Q5E9K0 PSB2_BOVIN 6.00E-82 GO:0005737; GO:0005634; GO:0005839; GO:0051603; GO:0004298 cytoplasm; nucleus; proteasome core complex; proteolysis involved in cellular protein catabolic process; threonine-type endopeptidase activity IPR016050; IPR001353; IPR023333; Proteasome subunit beta type-2 (EC 3.4.25.1) PSMB2 Bos taurus (Bovine) TR28196_c4_g5_i1 Q2TBP2 HINFP_BOVIN 4.00E-107 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Histone H4 transcription factor (Histone nuclear factor P) (HiNF-P) (MBD2-interacting zinc finger protein) (Methyl-CpG-binding protein 2-interacting zinc finger protein) HINFP MIZF Bos taurus (Bovine) TR2820_c0_g1_i1 Q460N5 PAR14_HUMAN 2.00E-10 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR28203_c1_g1_i1 Q04833 LRP_CAEEL 5.00E-21 GO:0016324; GO:0005509; GO:0005905; GO:0042395; GO:0030139; GO:0006897; GO:0016021; GO:0002119; GO:0040017; GO:0040018; GO:0030334; GO:0015248 "apical plasma membrane; calcium ion binding; coated pit; ecdysis, collagen and cuticulin-based cuticle; endocytic vesicle; endocytosis; integral to membrane; nematode larval development; positive regulation of locomotion; positive regulation of multicellular organism growth; regulation of cell migration; sterol transporter activity" IPR011042; IPR000742; IPR001881; IPR013032; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein (LRP) lrp-1 F29D11.1 Caenorhabditis elegans TR28204_c0_g2_i1 Q7M1R5 SODC_SOYBN 4.00E-27 GO:0005737; GO:0046872; GO:0004784; GO:0006801 cytoplasm; metal ion binding; superoxide dismutase activity; superoxide metabolic process IPR024134; IPR018152; IPR001424; Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) SOD1 Glycine max (Soybean) (Glycine hispida) TR28204_c0_g2_i2 P27082 SODC_NICPL 4.00E-25 GO:0005737; GO:0046872; GO:0004784; GO:0006801 cytoplasm; metal ion binding; superoxide dismutase activity; superoxide metabolic process IPR024134; IPR018152; IPR001424; Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) SODCC Nicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco) TR28205_c2_g2_i2 Q14DK5 HIPL1_MOUSE 5.00E-52 GO:0005975; GO:0005576; GO:0016020; GO:0016901; GO:0048038; GO:0005044 "carbohydrate metabolic process; extracellular region; membrane; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor; quinone binding; scavenger receptor activity" IPR011042; IPR018143; IPR012938; IPR011041; IPR001190; IPR017448; HHIP-like protein 1 Hhipl1 Hhip2 Kiaa1822 Mus musculus (Mouse) TR28206_c0_g2_i1 Q9D9N8 PADC1_MOUSE 2.00E-40 GO:0005576 extracellular region IPR003137; Protease-associated domain-containing protein 1 (Protease-associated domain-containing protein of 21 kDa) Pradc1 Pap21 Mus musculus (Mouse) TR28209_c1_g2_i1 Q91YK0 LRC49_MOUSE 5.00E-13 GO:0005737; GO:0005874 cytoplasm; microtubule IPR001611; IPR025875; Leucine-rich repeat-containing protein 49 (Tubulin polyglutamylase complex subunit 4) (PGs4) (p79) Lrrc49 Mus musculus (Mouse) TR28211_c5_g1_i1 Q96RK0 CIC_HUMAN 1.00E-24 GO:0003677; GO:0005634; GO:0006355; GO:0006351 P54253; Q9HC77 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009071; Protein capicua homolog CIC KIAA0306 Homo sapiens (Human) TR28214_c1_g1_i4 Q9H7V2 SYNG1_HUMAN 4.00E-09 GO:0044297; GO:0030054; GO:0043198; GO:0043197; GO:0031901; GO:0060076; GO:0035254; GO:0005887; GO:0006886; GO:0051965; GO:0014069; GO:0045211; GO:0042803; GO:0009607; GO:0097091 cell body; cell junction; dendritic shaft; dendritic spine; early endosome membrane; excitatory synapse; glutamate receptor binding; integral to plasma membrane; intracellular protein transport; positive regulation of synapse assembly; postsynaptic density; postsynaptic membrane; protein homodimerization activity; response to biotic stimulus; synaptic vesicle clustering IPR007593; Synapse differentiation-inducing gene protein 1 (SynDIG1) (Dispanin subfamily C member 2) (DSPC2) (Transmembrane protein 90B) SYNDIG1 C20orf39 TMEM90B Homo sapiens (Human) TR28220_c3_g1_i1 Q3U0M1 TPPC9_MOUSE 2.00E-35 GO:0005794; GO:0030154; GO:0005783 Golgi apparatus; cell differentiation; endoplasmic reticulum IPR013935; Trafficking protein particle complex subunit 9 (NIK- and IKBKB-binding protein) Trappc9 Kiaa1882 Nibp Mus musculus (Mouse) TR28221_c1_g1_i1 Q7Z304 MAMC2_HUMAN 2.00E-21 GO:0005783; GO:0005539; GO:0005614; GO:0016020; GO:0019800 endoplasmic reticulum; glycosaminoglycan binding; interstitial matrix; membrane; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IPR008985; IPR000998; MAM domain-containing protein 2 (MAM domain-containing proteoglycan) (Mamcan) MAMDC2 Homo sapiens (Human) TR28221_c1_g1_i2 Q91641 THIB_XENLA 2.00E-19 GO:0005615; GO:0016020; GO:0007275 extracellular space; membrane; multicellular organismal development IPR008985; IPR000998; Thyroid hormone-induced protein B Xenopus laevis (African clawed frog) TR28224_c2_g1_i1 Q49YE0 Y1056_STAS1 6.00E-06 GO:0005737; GO:0006950 cytoplasm; response to stress IPR014729; IPR006015; IPR006016; Putative universal stress protein SSP1056 SSP1056 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) TR28224_c2_g1_i2 P42297 YXIE_BACSU 5.00E-07 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein YxiE (USP YxiE) yxiE BSU39250 N17E Bacillus subtilis (strain 168) TR28229_c0_g1_i1 P60707 ACTB_TRIVU 0 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin, cytoplasmic 1 (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]" ACTB Trichosurus vulpecula (Brush-tailed possum) TR28229_c0_g1_i2 P17126 ACT_HYDVU 0 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin, non-muscle 6.2" Hydra vulgaris (Hydra) (Hydra attenuata) TR28229_c0_g1_i3 Q61WW9 ARP3_CAEBR 4.00E-60 GO:0005524; GO:0034314; GO:0005885; GO:0005737 ATP binding; Arp2/3 complex-mediated actin nucleation; Arp2/3 protein complex; cytoplasm IPR004000; IPR020902; IPR015623; Actin-related protein 3 (Actin-like protein 3) arx-1 CBG04224 Caenorhabditis briggsae TR28229_c0_g1_i4 Q9Y896 ACT2_SCHCO 1.00E-175 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; Actin-2 ACT2 AKT2 Schizophyllum commune (Split gill fungus) TR28229_c0_g1_i5 Q940Z2 ARP5_ARATH 1.00E-25 GO:0006281; GO:0031011; GO:0005737; GO:0005654; GO:0006355 "DNA repair; Ino80 complex; cytoplasm; nucleoplasm; regulation of transcription, DNA-dependent" IPR004000; IPR027664; Actin-related protein 5 ARP5 At3g12380 MQC3.19 T2E22.30 Arabidopsis thaliana (Mouse-ear cress) TR28229_c0_g1_i6 P30163 ACT2_ONCVO 0 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; Actin-2 act-2b Onchocerca volvulus TR28230_c2_g1_i1 Q8BJA3 HMBX1_MOUSE 3.00E-14 GO:0005737; GO:0045892; GO:0005634; GO:0045893; GO:0043565; GO:0003700; GO:0006351 "cytoplasm; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR006899; IPR001356; IPR009057; IPR010982; Homeobox-containing protein 1 Hmbox1 Mus musculus (Mouse) TR28232_c0_g1_i4 O50655 XERD_SELRU 4.00E-08 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR28232_c0_g1_i5 A8WHP9 LRRC3_DANRE 1.00E-08 GO:0016021 integral to membrane IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing protein 3 lrrc3 sc:d0333 si:dkey-253a1.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR28232_c0_g2_i1 O75325 LRRN2_HUMAN 2.00E-15 GO:0007155; GO:0016021; GO:0004872; GO:0007165 cell adhesion; integral to membrane; receptor activity; signal transduction IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeat neuronal protein 2 (Glioma amplified on chromosome 1 protein) (Leucine-rich repeat neuronal protein 5) LRRN2 GAC1 LRRN5 UNQ256/PRO293 Homo sapiens (Human) TR28232_c0_g2_i2 Q9BZR6 RTN4R_HUMAN 8.00E-15 GO:0031225; GO:0007409; GO:0009986; GO:0005783; GO:0050771; GO:0048011; GO:0005886; GO:0004872 Q8IZA0 anchored to membrane; axonogenesis; cell surface; endoplasmic reticulum; negative regulation of axonogenesis; neurotrophin TRK receptor signaling pathway; plasma membrane; receptor activity IPR000483; IPR001611; IPR003591; IPR000372; Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor) RTN4R NOGOR UNQ330/PRO526 Homo sapiens (Human) TR28236_c0_g1_i1 Q6DFF6 KLH20_XENLA 8.00E-79 GO:0031463; GO:0016605; GO:0005737; GO:0019964; GO:0043066; GO:0048471; GO:0043161; GO:0004842 Cul3-RING ubiquitin ligase complex; PML body; cytoplasm; interferon-gamma binding; negative regulation of apoptotic process; perinuclear region of cytoplasm; proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 20 klhl20 Xenopus laevis (African clawed frog) TR28237_c0_g1_i2 Q95JD5 ST1B1_CANFA 1.00E-52 GO:0004062; GO:0005737; GO:0009812; GO:0008202; GO:0051923; GO:0042403; GO:0006805 aryl sulfotransferase activity; cytoplasm; flavonoid metabolic process; steroid metabolic process; sulfation; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (cSULT1B1) (EC 2.8.2.-) SULT1B1 ST1B2 Canis familiaris (Dog) (Canis lupus familiaris) TR28238_c1_g1_i1 Q9P2E3 ZNFX1_HUMAN 1.00E-91 GO:0046872 metal ion binding IPR016024; IPR027417; NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) TR28239_c4_g1_i1 Q8IUZ0 LRC49_HUMAN 1.00E-22 GO:0005737; GO:0005874 cytoplasm; microtubule IPR001611; IPR025875; Leucine-rich repeat-containing protein 49 (Tubulin polyglutamylase complex subunit 4) (PGs4) LRRC49 Homo sapiens (Human) TR28240_c0_g1_i1 B3S4I5 LIS1_TRIAD 2.00E-17 GO:0051301; GO:0006928; GO:0005737; GO:0000132; GO:0005874; GO:0005875; GO:0005815; GO:0007067; GO:0006810 cell division; cellular component movement; cytoplasm; establishment of mitotic spindle orientation; microtubule; microtubule associated complex; microtubule organizing center; mitosis; transport IPR017252; IPR020472; IPR006594; IPR013720; IPR015943; IPR001680; IPR019775; IPR017986; Lissencephaly-1 homolog TRIADDRAFT_50647 Trichoplax adhaerens (Trichoplax reptans) TR28240_c0_g1_i2 Q5ZK69 PAAF1_CHICK 8.00E-74 GO:0000502 proteasome complex IPR015943; IPR001680; IPR019775; IPR017986; Proteasomal ATPase-associated factor 1 (WD repeat-containing protein 71) PAAF1 WDR71 RCJMB04_12m19 Gallus gallus (Chicken) TR28242_c0_g1_i1 Q96IR7 HPDL_HUMAN 6.00E-58 GO:0003868; GO:0009072; GO:0046872 4-hydroxyphenylpyruvate dioxygenase activity; aromatic amino acid family metabolic process; metal ion binding IPR005956; 4-hydroxyphenylpyruvate dioxygenase-like protein (EC 1.13.-.-) (Glyoxalase domain-containing protein 1) HPDL GLOXD1 Homo sapiens (Human) TR28244_c1_g1_i1 P42583 NKX25_XENLA 1.00E-37 GO:0007275; GO:0005634; GO:0043565; GO:0003700 multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein Nkx-2.5 (xNKx-2.5) (Homeobox protein NK-2 homolog E) nkx-2.5 Xenopus laevis (African clawed frog) TR28244_c1_g1_i2 Q8TAU0 NKX23_HUMAN 2.00E-39 GO:0043367; GO:0048541; GO:0022612; GO:0001776; GO:0050900; GO:0048535; GO:0030225; GO:0005634; GO:0042475; GO:0002317; GO:0045944; GO:0048621; GO:0042127; GO:0043565; GO:0003700; GO:0048536; GO:0006351; GO:0006641 "CD4-positive, alpha-beta T cell differentiation; Peyer's patch development; gland morphogenesis; leukocyte homeostasis; leukocyte migration; lymph node development; macrophage differentiation; nucleus; odontogenesis of dentin-containing tooth; plasma cell differentiation; positive regulation of transcription from RNA polymerase II promoter; post-embryonic digestive tract morphogenesis; regulation of cell proliferation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; spleen development; transcription, DNA-dependent; triglyceride metabolic process" IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein Nkx-2.3 (Homeobox protein NK-2 homolog C) NKX2-3 NKX23 NKX2C Homo sapiens (Human) TR28245_c0_g1_i2 O14975 S27A2_HUMAN 4.00E-134 GO:0005524; GO:0006699; GO:0005788; GO:0001561; GO:0006635; GO:0015245; GO:0030176; GO:0005779; GO:0044539; GO:0004467; GO:0097089; GO:0005739; GO:0050197; GO:0070251; GO:0042760; GO:0031957 ATP binding; bile acid biosynthetic process; endoplasmic reticulum lumen; fatty acid alpha-oxidation; fatty acid beta-oxidation; fatty acid transporter activity; integral to endoplasmic reticulum membrane; integral to peroxisomal membrane; long-chain fatty acid import; long-chain fatty acid-CoA ligase activity; methyl-branched fatty acid metabolic process; mitochondrion; phytanate-CoA ligase activity; pristanate-CoA ligase activity; very long-chain fatty acid catabolic process; very long-chain fatty acid-CoA ligase activity IPR025110; IPR020845; IPR000873; "Very long-chain acyl-CoA synthetase (VLACS) (VLCS) (EC 6.2.1.-) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 2) (THCA-CoA ligase) (Very long-chain-fatty-acid-CoA ligase)" SLC27A2 ACSVL1 FACVL1 FATP2 VLACS Homo sapiens (Human) TR28246_c0_g1_i1 Q24372 LACH_DROME 7.00E-35 GO:0031225; GO:0061343; GO:0007156; GO:0035160; GO:0016331; GO:0005886; GO:0042803; GO:0035151; GO:0005918; GO:0019991 Q9VGH2 "anchored to membrane; cell adhesion involved in heart morphogenesis; homophilic cell adhesion; maintenance of epithelial integrity, open tracheal system; morphogenesis of embryonic epithelium; plasma membrane; protein homodimerization activity; regulation of tube size, open tracheal system; septate junction; septate junction assembly" IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Lachesin Lac CG12369 Drosophila melanogaster (Fruit fly) TR28247_c0_g1_i1 Q9D4C6 LR2BP_MOUSE 2.00E-57 GO:0005737 cytoplasm IPR006597; IPR013026; IPR011990; IPR013105; IPR019734; LRP2-binding protein Lrp2bp Mus musculus (Mouse) TR28248_c0_g1_i3 Q8BNA6 FAT3_MOUSE 1.00E-19 GO:0005509; GO:0007156; GO:0016021; GO:0007275; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; multicellular organismal development; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Protocadherin Fat 3 (FAT tumor suppressor homolog 3) Fat3 Gm1132 Gm510 Mus musculus (Mouse) TR28248_c1_g1_i1 Q04721 NOTC2_HUMAN 9.00E-33 GO:0000139; GO:0007220; GO:0061314; GO:0006915; GO:0060413; GO:0046849; GO:0005509; GO:0007050; GO:0001709; GO:0016049; GO:0009986; GO:0005789; GO:0005576; GO:0030097; GO:0005887; GO:0043066; GO:0008285; GO:0007399; GO:0005654; GO:0046579; GO:0003184; GO:0004872; GO:0006355; GO:0019827; GO:0006367 "Golgi membrane; Notch receptor processing; Notch signaling involved in heart development; apoptotic process; atrial septum morphogenesis; bone remodeling; calcium ion binding; cell cycle arrest; cell fate determination; cell growth; cell surface; endoplasmic reticulum membrane; extracellular region; hemopoiesis; integral to plasma membrane; negative regulation of apoptotic process; negative regulation of cell proliferation; nervous system development; nucleoplasm; positive regulation of Ras protein signal transduction; pulmonary valve morphogenesis; receptor activity; regulation of transcription, DNA-dependent; stem cell maintenance; transcription initiation from RNA polymerase II promoter" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022336; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation; Notch 2 intracellular domain] NOTCH2 Homo sapiens (Human) TR28250_c1_g1_i1 Q92564 DCNL4_HUMAN 3.00E-59 IPR014764; IPR005176; DCN1-like protein 4 (DCUN1 domain-containing protein 4) (Defective in cullin neddylation protein 1-like protein 4) DCUN1D4 KIAA0276 Homo sapiens (Human) TR28252_c1_g2_i2 Q659A1 NARG2_HUMAN 4.00E-17 GO:0005634 nucleus IPR019535; NMDA receptor-regulated protein 2 NARG2 BRCC1 UNQ3101/PRO10100 Homo sapiens (Human) TR28255_c0_g1_i1 Q9U1X4 MSS4_CAEEL 5.00E-11 GO:0005085; GO:0015031; GO:0007264; GO:0008270 guanyl-nucleotide exchange factor activity; protein transport; small GTPase mediated signal transduction; zinc ion binding IPR007515; IPR011057; IPR011323; Putative guanine nucleotide exchange factor MSS4 homolog Y62E10A.11 Caenorhabditis elegans TR28255_c0_g1_i2 Q91X96 MSS4_MOUSE 5.00E-38 GO:0005085; GO:0015031; GO:0007264; GO:0008270 guanyl-nucleotide exchange factor activity; protein transport; small GTPase mediated signal transduction; zinc ion binding IPR007515; IPR011057; IPR011323; Guanine nucleotide exchange factor MSS4 (Rab-interacting factor) Rabif Mus musculus (Mouse) TR28256_c0_g1_i2 Q9KA72 DPO3_BACHD 1.00E-07 GO:0008408; GO:0003677; GO:0006260; GO:0003887; GO:0005737; GO:0090305 3'-5' exonuclease activity; DNA binding; DNA replication; DNA-directed DNA polymerase activity; cytoplasm; nucleic acid phosphodiester bond hydrolysis IPR011708; IPR028112; IPR024754; IPR006054; IPR006055; IPR013520; IPR012340; IPR004365; IPR004013; IPR003141; IPR006308; IPR012337; DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC BH2418 Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) TR28260_c0_g1_i1 Q6TFL4 KLH24_HUMAN 1.00E-19 GO:0030424; GO:0005737; GO:0043204 axon; cytoplasm; perikaryon IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) KLHL24 DRE1 Homo sapiens (Human) TR28260_c2_g1_i1 D3Z8N4 KLH20_RAT 2.00E-48 GO:0031463; GO:0005794; GO:0016605; GO:0009986; GO:0005737; GO:0019964; GO:0043066; GO:0048471; GO:0043161; GO:0004842 Cul3-RING ubiquitin ligase complex; Golgi apparatus; PML body; cell surface; cytoplasm; interferon-gamma binding; negative regulation of apoptotic process; perinuclear region of cytoplasm; proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 20 Klhl20 Rattus norvegicus (Rat) TR28263_c3_g1_i1 P82102 MYNB_MYTGA 1.00E-07 GO:0042742; GO:0050832; GO:0005576; GO:0031640 defense response to bacterium; defense response to fungus; extracellular region; killing of cells of other organism IPR019631; Myticin-B Mytilus galloprovincialis (Mediterranean mussel) TR28264_c0_g1_i1 Q8VHT8 TF3A_RAT 3.00E-65 GO:0003677; GO:0003723; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; RNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Transcription factor IIIA (TFIIIA) Gtf3a Rattus norvegicus (Rat) TR28266_c2_g1_i1 Q69YH5 CDCA2_HUMAN 9.00E-06 GO:0051301; GO:0005737; GO:0007067; GO:0005634 cell division; cytoplasm; mitosis; nucleus IPR026149; Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) CDCA2 Homo sapiens (Human) TR28274_c1_g1_i1 P58545 BTBD3_MOUSE 2.00E-46 IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 3 Btbd3 Mus musculus (Mouse) TR28274_c1_g1_i3 Q8K2J9 BTBD6_MOUSE 8.00E-48 GO:0000932 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6 Btbd6 Mus musculus (Mouse) TR28275_c4_g1_i2 Q8C6C7 F204A_MOUSE 7.00E-18 Protein FAM204A Fam204a D19Ertd737e Mus musculus (Mouse) TR28277_c2_g2_i1 Q3ZBP8 CO040_BOVIN 2.00E-22 IPR003746; UPF0235 protein C15orf40 homolog Bos taurus (Bovine) TR28277_c2_g2_i2 B0TGP1 Y2027_HELMI 3.00E-14 IPR003746; UPF0235 protein Helmi_20270 Helmi_20270 HM1_2095 Heliobacterium modesticaldum (strain ATCC 51547 / Ice1) TR28283_c0_g1_i1 Q554G3 COMDA_DICDI 2.00E-19 IPR017920; IPR009886; COMM domain-containing protein 10 commd10 DDB_G0275249 Dictyostelium discoideum (Slime mold) TR28283_c0_g1_i2 Q9Y6G5 COMDA_HUMAN 9.00E-52 IPR017920; IPR009886; COMM domain-containing protein 10 COMMD10 HSPC305 PTD002 Homo sapiens (Human) TR28287_c2_g1_i1 Q9Z1Z3 EPN2_RAT 1.00E-109 GO:0030128; GO:0006897; GO:0008289; GO:0030100 clathrin coat of endocytic vesicle; endocytosis; lipid binding; regulation of endocytosis IPR008942; IPR013809; IPR001026; IPR003903; Epsin-2 (EPS-15-interacting protein 2) Epn2 Rattus norvegicus (Rat) TR28287_c2_g1_i2 Q54EH1 EPN_DICDI 2.00E-43 GO:0030276; GO:0030136; GO:0005905; GO:0000331; GO:0000281; GO:0005546; GO:0005886; GO:0035304; GO:0030435 "clathrin binding; clathrin-coated vesicle; coated pit; contractile vacuole; mitotic cytokinesis; phosphatidylinositol-4,5-bisphosphate binding; plasma membrane; regulation of protein dephosphorylation; sporulation resulting in formation of a cellular spore" IPR008942; IPR013809; IPR001026; Epsin epnA DDB_G0291512 Dictyostelium discoideum (Slime mold) TR28288_c1_g4_i1 Q8CI85 CAH12_MOUSE 4.00E-57 GO:0004089; GO:0016021; GO:0006730; GO:0008270 carbonate dehydratase activity; integral to membrane; one-carbon metabolic process; zinc ion binding IPR001148; IPR023561; IPR018338; IPR018430; Carbonic anhydrase 12 (EC 4.2.1.1) (Carbonate dehydratase XII) (Carbonic anhydrase XII) (CA-XII) Ca12 Car12 Mus musculus (Mouse) TR28288_c2_g1_i1 Q9H4E7 DEFI6_HUMAN 4.00E-32 GO:0005737; GO:0005634; GO:0005543; GO:0005886 cytoplasm; nucleus; phospholipid binding; plasma membrane IPR011993; IPR001849; Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) DEF6 IBP Homo sapiens (Human) TR28293_c0_g1_i2 Q869C3 ACES_ANOGA 1.00E-23 GO:0003990; GO:0004091; GO:0030054; GO:0019695; GO:0042135; GO:0045202; GO:0007271 "acetylcholinesterase activity; carboxylesterase activity; cell junction; choline metabolic process; neurotransmitter catabolic process; synapse; synaptic transmission, cholinergic" IPR002018; IPR019826; IPR019819; IPR000997; Acetylcholinesterase (AChE) (EC 3.1.1.7) Ace ACE1 ACHE1 AGAP001356 Anopheles gambiae (African malaria mosquito) TR28294_c0_g1_i2 P82649 RT22_BOVIN 1.00E-43 GO:0005739; GO:0005840 mitochondrion; ribosome IPR019374; "28S ribosomal protein S22, mitochondrial (MRP-S22) (S22mt)" MRPS22 Bos taurus (Bovine) TR28296_c0_g4_i1 Q5RFR6 K319L_PONAB 3.00E-46 GO:0031410; GO:0016021 cytoplasmic vesicle; integral to membrane IPR003961; IPR013980; IPR022409; IPR002859; IPR000601; Dyslexia-associated protein KIAA0319-like protein KIAA0319L Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR28299_c2_g1_i1 Q61K76 EIF3K_CAEBR 2.00E-48 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0006446; GO:0043022; GO:0003743 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; regulation of translational initiation; ribosome binding; translation initiation factor activity IPR016024; IPR009374; IPR005062; IPR016020; IPR011991; Eukaryotic translation initiation factor 3 subunit K (eIF3k) (eIF-3 p25) eif-3.K CBG09495 Caenorhabditis briggsae TR28299_c2_g1_i2 Q28C65 EIF3K_XENTR 3.00E-97 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0005634; GO:0006446; GO:0043022; GO:0003743; GO:0006413 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; nucleus; regulation of translational initiation; ribosome binding; translation initiation factor activity; translational initiation IPR016024; IPR009374; IPR016020; IPR011991; Eukaryotic translation initiation factor 3 subunit K (eIF3k) (Eukaryotic translation initiation factor 3 subunit 12) (eIF-3 p25) eif3k eif3s12 TTpA007f24.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28300_c0_g1_i1 Q9ERC1 MYO16_RAT 6.00E-11 GO:0005524; GO:0003779; GO:0051015; GO:0021549; GO:0005829; GO:0016020; GO:0003774; GO:0016459; GO:2000134; GO:0008285; GO:0005730; GO:0005654; GO:0048471; GO:0005886 ATP binding; actin binding; actin filament binding; cerebellum development; cytosol; membrane; motor activity; myosin complex; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell proliferation; nucleolus; nucleoplasm; perinuclear region of cytoplasm; plasma membrane IPR002110; IPR020683; IPR000048; IPR001609; IPR027417; Unconventional myosin-XVI (Myosin heavy chain myr 8) (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16) Myo16 Myr8 Nyap3 Rattus norvegicus (Rat) TR28300_c0_g2_i1 Q9Z2X3 PSD10_RAT 9.00E-13 GO:0006915; GO:0005737; GO:0007253; GO:0043518; GO:0043409; GO:0032088; GO:0043066; GO:0090201; GO:0000122; GO:0005634; GO:0030307; GO:0045737; GO:0032436; GO:0031398; GO:0070682 "apoptotic process; cytoplasm; cytoplasmic sequestering of NF-kappaB; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of MAPK cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of apoptotic process; negative regulation of release of cytochrome c from mitochondria; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of cell growth; positive regulation of cyclin-dependent protein kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; proteasome regulatory particle assembly" IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) Psmd10 Rattus norvegicus (Rat) TR28300_c0_g3_i1 Q5UPG5 YL093_MIMIV 1.00E-17 IPR002110; IPR020683; Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) TR28301_c0_g1_i1 Q6YHK3 CD109_HUMAN 9.00E-12 GO:0031225; GO:0005615; GO:0010951; GO:0005886; GO:0004867 anchored to membrane; extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) TR28302_c2_g1_i1 Q9QSK3 VF030_IIV6 3.00E-16 GO:0032508; GO:0003678; GO:0006281; GO:0000166; GO:0000723 DNA duplex unwinding; DNA helicase activity; DNA repair; nucleotide binding; telomere maintenance IPR003593; IPR010285; IPR027417; Uncharacterized protein 030L IIV6-030L Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) TR28303_c1_g1_i1 Q96FC7 PHIPL_HUMAN 2.00E-24 GO:0005737; GO:0005739 cytoplasm; mitochondrion IPR003961; IPR013783; Phytanoyl-CoA hydroxylase-interacting protein-like PHYHIPL KIAA1796 UNQ6309/PRO20934 Homo sapiens (Human) TR28310_c1_g1_i1 Q3KQF4 LRC69_XENLA 7.00E-49 IPR001611; IPR025875; IPR003591; Leucine-rich repeat-containing protein 69 lrrc69 Xenopus laevis (African clawed frog) TR28310_c3_g1_i2 Q60754 MARCO_MOUSE 3.00E-25 GO:0043277; GO:0005581; GO:0045087; GO:0016021; GO:0005886; GO:0005044 apoptotic cell clearance; collagen; innate immune response; integral to membrane; plasma membrane; scavenger receptor activity IPR008160; IPR001190; IPR017448; Macrophage receptor MARCO (Macrophage receptor with collagenous structure) Marco Mus musculus (Mouse) TR28316_c1_g2_i1 Q96GN5 CDA7L_HUMAN 4.00E-51 GO:0005737; GO:0005730; GO:0008284; GO:0006355; GO:0006351 "cytoplasm; nucleolus; positive regulation of cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR018866; Cell division cycle-associated 7-like protein (Protein JPO2) (Transcription factor RAM2) CDCA7L HR1 JPO2 R1 Homo sapiens (Human) TR28318_c0_g1_i1 P62262 1433E_SHEEP 2.00E-142 GO:0042470 melanosome IPR000308; IPR023409; IPR023410; 14-3-3 protein epsilon (14-3-3E) (Protein kinase C inhibitor protein 1) (KCIP-1) YWHAE Ovis aries (Sheep) TR28319_c1_g3_i1 O75311 GLRA3_HUMAN 2.00E-91 GO:0030054; GO:0034707; GO:0005230; GO:0016934; GO:0016594; GO:0016021; GO:0005887; GO:0005886; GO:0045211; GO:0007268; GO:0022824 cell junction; chloride channel complex; extracellular ligand-gated ion channel activity; extracellular-glycine-gated chloride channel activity; glycine binding; integral to membrane; integral to plasma membrane; plasma membrane; postsynaptic membrane; synaptic transmission; transmitter-gated ion channel activity IPR006028; IPR008127; IPR008130; IPR006202; IPR006201; IPR006029; IPR018000; Glycine receptor subunit alpha-3 GLRA3 Homo sapiens (Human) TR28320_c0_g1_i1 Q6RWA9 AT1A_TAESO 4.00E-65 GO:0005524; GO:0006754; GO:0016021; GO:0046872; GO:0005391 ATP binding; ATP biosynthetic process; integral to membrane; metal ion binding; sodium:potassium-exchanging ATPase activity IPR006068; IPR004014; IPR023299; IPR005775; IPR018303; IPR023298; IPR008250; IPR001757; IPR023214; Sodium/potassium-transporting ATPase subunit alpha (Na(+)/K(+) ATPase alpha subunit) (EC 3.6.3.9) (Sodium pump subunit alpha) (TNaK1-alpha) Taenia solium (Pork tapeworm) TR28321_c0_g1_i3 A3KQI3 MF2NB_DANRE 2.00E-30 IPR019320; Protein MEF2BNB (MEF2B neighbor gene protein homolog) (mef2b neighbor gene transcript) mef2bnb si:ch211-125m10.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR28321_c0_g1_i4 Q8IR45 MF2NB_DROME 4.00E-30 IPR019320; Protein MEF2BNB homolog CG32590 Drosophila melanogaster (Fruit fly) TR28322_c0_g1_i1 O57321 EAA1_AMBTI 1.00E-32 GO:0016021; GO:0017153 integral to membrane; sodium:dicarboxylate symporter activity IPR001991; IPR018107; Excitatory amino acid transporter 1 (SEAAT1) SLC1A3 EAAT1 Ambystoma tigrinum (Eastern tiger salamander) TR28322_c0_g2_i2 O57321 EAA1_AMBTI 2.00E-48 GO:0016021; GO:0017153 integral to membrane; sodium:dicarboxylate symporter activity IPR001991; IPR018107; Excitatory amino acid transporter 1 (SEAAT1) SLC1A3 EAAT1 Ambystoma tigrinum (Eastern tiger salamander) TR28324_c2_g1_i1 P23414 ACH1_SCHGR 7.00E-11 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha-L1 Schistocerca gregaria (Desert locust) TR28324_c2_g6_i2 P43143 ACHA6_RAT 4.00E-20 GO:0004889; GO:0005892; GO:0030054; GO:0008144; GO:0045211; GO:0051291 acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; drug binding; postsynaptic membrane; protein heterooligomerization IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Acra6 Rattus norvegicus (Rat) TR28329_c2_g1_i1 P79110 TXTP_BOVIN 3.00E-111 GO:0016021; GO:0005743; GO:0055085 integral to membrane; mitochondrial inner membrane; transmembrane transport IPR002067; IPR018108; IPR023395; "Tricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein)" SLC25A1 SLC20A3 Bos taurus (Bovine) TR28329_c2_g2_i1 Q551X6 MCFV_DICDI 2.00E-08 GO:0016021; GO:0005743; GO:0055085 integral to membrane; mitochondrial inner membrane; transmembrane transport IPR002067; IPR018108; IPR023395; Mitochondrial substrate carrier family protein V mcfV DDB_G0276261 Dictyostelium discoideum (Slime mold) TR2833_c0_g1_i1 Q9QZ85 IIGP1_MOUSE 6.00E-18 GO:0019003; GO:0005525; GO:0003924; GO:0032580; GO:0035458; GO:0019221; GO:0050829; GO:0042832; GO:0005789; GO:0042802; GO:0045087; GO:0031965; GO:0010506; GO:0020005 GDP binding; GTP binding; GTPase activity; Golgi cisterna membrane; cellular response to interferon-beta; cytokine-mediated signaling pathway; defense response to Gram-negative bacterium; defense response to protozoan; endoplasmic reticulum membrane; identical protein binding; innate immune response; nuclear membrane; regulation of autophagy; symbiont-containing vacuole membrane IPR007743; IPR027417; Interferon-inducible GTPase 1 (EC 3.6.5.-) Iigp1 Irga6 Mus musculus (Mouse) TR28330_c0_g1_i2 P02595 CALM_PATSP 4.00E-13 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) Patinopecten sp. (Scallop) TR28331_c0_g1_i1 Q1JPD2 ABHGA_BOVIN 1.00E-154 GO:0016787; GO:0016021 hydrolase activity; integral to membrane IPR026604; Abhydrolase domain-containing protein 16A (EC 3.-.-.-) (HLA-B-associated transcript 5) ABHD16A BAT5 Bos taurus (Bovine) TR28332_c0_g1_i1 O60669 MOT2_HUMAN 2.00E-39 GO:0005887; GO:0005477; GO:0015355; GO:0015293 integral to plasma membrane; pyruvate secondary active transmembrane transporter activity; secondary active monocarboxylate transmembrane transporter activity; symporter activity IPR027178; IPR011701; IPR020846; IPR016196; IPR004743; Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) SLC16A7 MCT2 Homo sapiens (Human) TR28333_c1_g2_i1 P09402 MLE_DICDI 9.00E-26 GO:0030898; GO:0042641; GO:0005509; GO:0016477; GO:0000281; GO:0016460; GO:0030587 actin-dependent ATPase activity; actomyosin; calcium ion binding; cell migration; mitotic cytokinesis; myosin II complex; sorocarp development IPR011992; IPR018247; IPR002048; "Myosin, essential light chain (EMLC) (Myosin light chain alkali)" mlcE mlcB DDB_G0277859 Dictyostelium discoideum (Slime mold) TR28333_c1_g3_i1 P62154 CALM_LOCMI 2.00E-97 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Locusta migratoria (Migratory locust) TR28333_c1_g3_i2 Q84VG0 CML7_ORYSJ 9.00E-46 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Probable calcium-binding protein CML7 (Calmodulin-like protein 7) CML7 Os08g0117400 LOC_Os08g02420 OsJ_024805 P0470F10.20 Oryza sativa subsp. japonica (Rice) TR28333_c1_g3_i3 O82040 POLC7_PHLPR 4.00E-08 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Polcalcin Phl p 7 (Calcium-binding pollen allergen Phl p 7) (P7) (allergen Phl p 7) Phleum pratense (Common timothy) TR28333_c1_g3_i4 P04630 CALL_CAEEL 2.00E-63 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-like protein cal-1 cmd-1 C13C12.1 Caenorhabditis elegans TR28333_c1_g3_i5 Q95NR9 CALM_METSE 2.00E-100 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Metridium senile (Brown sea anemone) (Frilled sea anemone) TR28333_c1_g3_i6 Q8STF0 CALM_STRIE 2.00E-88 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Strongylocentrotus intermedius (Sea urchin) TR28335_c1_g1_i1 P02637 SCP_MIZYE 9.00E-31 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Sarcoplasmic calcium-binding protein (SCP) Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) TR28336_c1_g1_i1 B1WB06 MET24_XENTR 5.00E-17 GO:0005576; GO:0008168 extracellular region; methyltransferase activity IPR025714; IPR026913; Methyltransferase-like protein 24 (EC 2.1.1.-) mettl24 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28337_c3_g2_i1 Q9V4M2 WECH_DROME 9.00E-07 GO:0030154; GO:0002168; GO:0005622; GO:0016203; GO:0005927; GO:0033632; GO:0008270 cell differentiation; instar larval development; intracellular; muscle attachment; muscle tendon junction; regulation of cell-cell adhesion mediated by integrin; zinc ion binding IPR011042; IPR001258; IPR013017; IPR000315; Protein wech (Protein dappled) wech dpld CG42396 Drosophila melanogaster (Fruit fly) TR28338_c2_g1_i1 Q8AXF4 FBX43_XENLA 3.00E-11 GO:0007126; GO:0016567; GO:0008270 meiosis; protein ubiquitination; zinc ion binding IPR001810; IPR002867; Protein modification; protein ubiquitination. F-box only protein 43 (Early mitotic inhibitor 2) (Emi1-related protein 1) (F-box protein 26) (Xerp1) fbxo43 emi2 erp1 fbx26 Xenopus laevis (African clawed frog) TR28340_c0_g1_i1 Q6ZNB6 NFXL1_HUMAN 4.00E-08 GO:0016021; GO:0005634; GO:0003700; GO:0008270 integral to membrane; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding IPR019786; IPR000967; IPR001841; NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) NFXL1 OZFP Homo sapiens (Human) TR28343_c0_g2_i1 Q0VCQ4 RRFM_BOVIN 5.00E-38 GO:0005739; GO:0006412 mitochondrion; translation IPR024946; IPR002661; IPR023584; "Ribosome-recycling factor, mitochondrial (RRF) (Ribosome-releasing factor, mitochondrial)" MRRF Bos taurus (Bovine) TR28343_c0_g2_i2 Q0VCQ4 RRFM_BOVIN 7.00E-38 GO:0005739; GO:0006412 mitochondrion; translation IPR024946; IPR002661; IPR023584; "Ribosome-recycling factor, mitochondrial (RRF) (Ribosome-releasing factor, mitochondrial)" MRRF Bos taurus (Bovine) TR28348_c0_g1_i1 Q8K0U4 HS12A_MOUSE 9.00E-11 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR28353_c0_g1_i1 O45228 PROD_CAEEL 0 GO:0071949; GO:0005509; GO:0006537; GO:0005759; GO:0010133; GO:0004657 FAD binding; calcium ion binding; glutamate biosynthetic process; mitochondrial matrix; proline catabolic process to glutamate; proline dehydrogenase activity IPR011992; IPR002872; IPR015659; Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2. "Proline dehydrogenase 1, mitochondrial (EC 1.5.99.8) (Proline oxidase)" B0513.5 Caenorhabditis elegans TR28356_c2_g1_i1 Q5EAW9 TAF3_XENLA 1.00E-23 GO:0005634; GO:0006355; GO:0006351; GO:0008270 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) taf3 Xenopus laevis (African clawed frog) TR28356_c3_g1_i1 Q5VWG9 TAF3_HUMAN 5.00E-33 GO:0051457; GO:0043433; GO:0000122; GO:0005669; GO:0006351; GO:0008270 P84243 "maintenance of protein location in nucleus; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; transcription factor TFIID complex; transcription, DNA-dependent; zinc ion binding" IPR006565; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140) TAF3 Homo sapiens (Human) TR28357_c0_g1_i1 A8MW99 MEI4L_HUMAN 4.00E-07 GO:0006310; GO:0000800; GO:0042138; GO:0048477; GO:0007283; GO:0007129 DNA recombination; lateral element; meiotic DNA double-strand break formation; oogenesis; spermatogenesis; synapsis IPR025888; Meiosis-specific protein MEI4-like MEI4 Homo sapiens (Human) TR28358_c0_g1_i1 P55012 S12A2_MOUSE 7.00E-63 GO:0016324; GO:0016323; GO:0060444; GO:0015377; GO:0050910; GO:0016021; GO:0060763; GO:0035264; GO:0006813; GO:0006814 P47811; Q9Z1W9 apical plasma membrane; basolateral plasma membrane; branching involved in mammary gland duct morphogenesis; cation:chloride symporter activity; detection of mechanical stimulus involved in sensory perception of sound; integral to membrane; mammary duct terminal end bud growth; multicellular organism growth; potassium ion transport; sodium ion transport IPR004841; IPR013612; IPR002443; IPR002444; IPR004842; Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) Slc12a2 Nkcc1 Mus musculus (Mouse) TR28361_c3_g1_i2 Q9NZR2 LRP1B_HUMAN 5.00E-10 GO:0005509; GO:0016021; GO:0005041; GO:0015031; GO:0006898 calcium ion binding; integral to membrane; low-density lipoprotein receptor activity; protein transport; receptor-mediated endocytosis IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) LRP1B LRPDIT Homo sapiens (Human) TR28361_c3_g1_i3 Q8WXD0 RXFP2_HUMAN 5.00E-06 GO:0007189; GO:0007193; GO:0016021; GO:0008584; GO:0043066; GO:0008285; GO:0001556; GO:0017046; GO:0005886; GO:0030819; GO:0016500 adenylate cyclase-activating G-protein coupled receptor signaling pathway; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; integral to membrane; male gonad development; negative regulation of apoptotic process; negative regulation of cell proliferation; oocyte maturation; peptide hormone binding; plasma membrane; positive regulation of cAMP biosynthetic process; protein-hormone receptor activity IPR000276; IPR017452; IPR023415; IPR002172; IPR001611; IPR003591; IPR000372; IPR008112; Relaxin receptor 2 (G-protein coupled receptor 106) (G-protein coupled receptor affecting testicular descent) (Leucine-rich repeat-containing G-protein coupled receptor 8) (Relaxin family peptide receptor 2) RXFP2 GPR106 GREAT LGR8 Homo sapiens (Human) TR28367_c0_g1_i2 Q1T7B7 CENPP_CHICK 8.00E-19 GO:0034080; GO:0000775; GO:0005634 "CENP-A containing nucleosome assembly at centromere; chromosome, centromeric region; nucleus" IPR027801; Centromere protein P (CENP-P) CENPP Gallus gallus (Chicken) TR28369_c0_g1_i2 Q8IVL1 NAV2_HUMAN 2.00E-28 GO:0005524; GO:0021563; GO:0004386; GO:0008201; GO:0005614; GO:0007626; GO:0005634; GO:0021554; GO:0003025; GO:0007608; GO:0007605; GO:0021564 ATP binding; glossopharyngeal nerve development; helicase activity; heparin binding; interstitial matrix; locomotory behavior; nucleus; optic nerve development; regulation of systemic arterial blood pressure by baroreceptor feedback; sensory perception of smell; sensory perception of sound; vagus nerve development IPR003593; IPR001715; IPR027417; Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2 Homo sapiens (Human) TR28369_c0_g1_i3 Q5TZ18 NAV3_DANRE 1.00E-27 GO:0005524; GO:0005640; GO:0017111 ATP binding; nuclear outer membrane; nucleoside-triphosphatase activity IPR003593; IPR003959; IPR001715; IPR027417; Neuron navigator 3 nav3 si:dkeyp-60g2.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR28370_c1_g1_i2 P19477 FIBA_PARPA 1.00E-38 IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein A (FREP-A) Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) TR28370_c1_g1_i4 Q9WVH6 ANGP4_MOUSE 8.00E-25 GO:0048014; GO:0001525; GO:0071456; GO:0007492; GO:0005615; GO:0016525; GO:0043066; GO:0043537; GO:0045766; GO:0043536; GO:0030297; GO:0005172 Tie signaling pathway; angiogenesis; cellular response to hypoxia; endoderm development; extracellular space; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of blood vessel endothelial cell migration; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; transmembrane receptor protein tyrosine kinase activator activity; vascular endothelial growth factor receptor binding IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3) Angpt4 Agpt4 Ang3 Mus musculus (Mouse) TR28371_c0_g1_i1 Q3KPR5 BIVM_XENLA 2.00E-37 GO:0005737; GO:0005634 cytoplasm; nucleus Basic immunoglobulin-like variable motif-containing protein bivm Xenopus laevis (African clawed frog) TR28371_c2_g2_i1 A8B6A2 BIVM_GIAIC 7.00E-07 Basic immunoglobulin-like variable motif-containing protein BIVM BIVML GL50803_13101 Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia) TR28372_c0_g1_i1 Q9MYP6 DHB14_BOVIN 6.00E-85 GO:0005813; GO:0005829; GO:0004303; GO:0006706; GO:0047045 centrosome; cytosol; estradiol 17-beta-dehydrogenase activity; steroid catabolic process; testosterone 17-beta-dehydrogenase (NADP+) activity IPR002198; IPR002347; IPR016040; IPR020904; 17-beta-hydroxysteroid dehydrogenase 14 (17-beta-HSD 14) (EC 1.1.1.-) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) HSD17B14 DHRS10 SDR3 Bos taurus (Bovine) TR28372_c0_g1_i3 O32185 YUSS_BACSU 1.00E-07 GO:0055114; GO:0016491 oxidation-reduction process; oxidoreductase activity IPR002198; IPR002347; IPR016040; Short-chain dehydrogenase/reductase homolog YusS yusS BSU32910 Bacillus subtilis (strain 168) TR28372_c0_g1_i4 Q9Z8P2 FABG_CHLPN 1.00E-31 GO:0004316; GO:0051287; GO:0006633 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NAD binding; fatty acid biosynthetic process IPR011284; IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) (Beta-Ketoacyl-acyl carrier protein reductase) (Beta-ketoacyl-ACP reductase) fabG CPn_0296 CP_0462 CpB0305 Chlamydia pneumoniae (Chlamydophila pneumoniae) TR28378_c1_g1_i1 O73791 TIE2_DANRE 7.00E-25 GO:0005524; GO:0005737; GO:0005856; GO:0005925; GO:0007507; GO:0005887; GO:0018108; GO:0004714; GO:0007169 ATP binding; cytoplasm; cytoskeleton; focal adhesion; heart development; integral to plasma membrane; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000742; IPR013032; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR011009; IPR000719; IPR017441; IPR001245; IPR018941; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-2 (EC 2.7.10.1) (Tyrosine kinase with Ig and EGF homology domains-2) tie2 tie-2 Danio rerio (Zebrafish) (Brachydanio rerio) TR28378_c2_g1_i1 Q80T91 MEG11_MOUSE 1.00E-73 GO:0016323; GO:0034109; GO:0016021; GO:0010842 basolateral plasma membrane; homotypic cell-cell adhesion; integral to membrane; retina layer formation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) TR28378_c2_g1_i2 O75095 MEGF6_HUMAN 1.00E-64 GO:0005509; GO:0005576 O15265; O00555 calcium ion binding; extracellular region IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR002049; IPR011489; IPR009030; Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) TR28378_c2_g1_i6 Q0D2K5 EGFEM_HUMAN 4.00E-13 Putative EGF-like and EMI domain-containing protein 1 EGFEM1P C3orf50 NCRNA00259 Homo sapiens (Human) TR28379_c0_g1_i2 H2A0L1 TYRO2_PINMG 4.00E-48 GO:0005576; GO:0046872; GO:0016491 extracellular region; metal ion binding; oxidoreductase activity IPR002227; IPR008922; Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2) Pinctada margaritifera (Black-lipped pearl oyster) TR28379_c0_g1_i3 P55025 TYRO_ORYLA 2.00E-06 GO:0016021; GO:0042438; GO:0033162; GO:0046872; GO:0004503 integral to membrane; melanin biosynthetic process; melanosome membrane; metal ion binding; monophenol monooxygenase activity IPR002227; IPR008922; Tyrosinase (EC 1.14.18.1) (Monophenol monooxygenase) tyr tyro Oryzias latipes (Medaka fish) (Japanese ricefish) TR28379_c0_g1_i4 H2A0L0 TYRO1_PINMG 2.00E-38 GO:0005576; GO:0046872; GO:0016491 extracellular region; metal ion binding; oxidoreductase activity IPR002227; IPR008922; Tyrosinase-like protein 1 (EC 1.14.18.-) (Tyrosinase 1) Pinctada margaritifera (Black-lipped pearl oyster) TR2838_c0_g1_i1 Q98943 CASP2_CHICK 4.00E-31 GO:0006915; GO:0004197; GO:0005622; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; intracellular; proteolysis; regulation of apoptotic process IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) TR28381_c0_g1_i1 P77735 YAJO_ECOLI 1.00E-57 GO:0016491; GO:0006772 oxidoreductase activity; thiamine metabolic process IPR001395; IPR020471; IPR023210; Uncharacterized oxidoreductase YajO (EC 1.-.-.-) yajO b0419 JW0409 Escherichia coli (strain K12) TR28381_c0_g1_i2 P77256 YDJG_ECOLI 2.00E-17 GO:0004033 aldo-keto reductase (NADP) activity IPR001395; IPR020471; IPR023210; Uncharacterized oxidoreductase YdjG (EC 1.-.-.-) ydjG b1771 JW1760 Escherichia coli (strain K12) TR28381_c0_g1_i3 O59826 KCAB_SCHPO 6.00E-34 GO:0005829; GO:0016021; GO:0005634; GO:0006813; GO:0005244 cytosol; integral to membrane; nucleus; potassium ion transport; voltage-gated ion channel activity IPR001395; IPR005399; IPR005400; IPR023210; Putative voltage-gated potassium channel subunit beta (K(+) channel subunit beta) SPCC965.06 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR28382_c0_g1_i1 Q8NWQ4 TDCB_STAAW 4.00E-34 GO:0004794; GO:0070689; GO:0000166; GO:0030170 L-threonine ammonia-lyase activity; L-threonine catabolic process to propionate; nucleotide binding; pyridoxal phosphate binding IPR000634; IPR005789; IPR001926; Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine: step 1/4. L-threonine dehydratase catabolic TdcB (EC 4.3.1.19) (Threonine deaminase) tdcB MW1327 Staphylococcus aureus (strain MW2) TR28385_c1_g4_i1 Q8NFZ5 TNIP2_HUMAN 3.00E-15 GO:0023035; GO:0007249; GO:0006915; GO:0071222; GO:0005829; GO:0006954; GO:0070498; GO:2000352; GO:0005634; GO:0031593; GO:0050871; GO:0043123; GO:0043032; GO:0045944; GO:0019901; GO:0050821; GO:0034134; GO:0034138; GO:0034162; GO:0006351 Q9Y6K9; P41279; P19838-1; Q15831 "CD40 signaling pathway; I-kappaB kinase/NF-kappaB cascade; apoptotic process; cellular response to lipopolysaccharide; cytosol; inflammatory response; interleukin-1-mediated signaling pathway; negative regulation of endothelial cell apoptotic process; nucleus; polyubiquitin binding; positive regulation of B cell activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macrophage activation; positive regulation of transcription from RNA polymerase II promoter; protein kinase binding; protein stabilization; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 9 signaling pathway; transcription, DNA-dependent" IPR022008; TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2) (ABIN-2) (Fetal liver LKB1-interacting protein) TNIP2 ABIN2 FLIP1 Homo sapiens (Human) TR28389_c1_g1_i1 Q5SDA5 GUC2F_MOUSE 8.00E-53 GO:0005524; GO:0005525; GO:0004383; GO:0016021; GO:0035556; GO:0004672; GO:0007601 ATP binding; GTP binding; guanylate cyclase activity; integral to membrane; intracellular signal transduction; protein kinase activity; visual perception IPR001054; IPR018297; IPR001828; IPR011009; IPR028082; IPR000719; IPR001245; Retinal guanylyl cyclase 2 (EC 4.6.1.2) Gucy2f Mus musculus (Mouse) TR28389_c4_g1_i1 Q7T6Y2 YR831_MIMIV 3.00E-07 GO:0005524; GO:0009190; GO:0016021; GO:0035556; GO:0016849; GO:0004674 ATP binding; cyclic nucleotide biosynthetic process; integral to membrane; intracellular signal transduction; phosphorus-oxygen lyase activity; protein serine/threonine kinase activity IPR001054; IPR011009; IPR024370; IPR000719; IPR017441; IPR001245; IPR002290; IPR008271; Putative serine/threonine-protein kinase/receptor R831 (EC 2.7.11.1) MIMI_R831 Acanthamoeba polyphaga mimivirus (APMV) TR28392_c0_g1_i2 Q6IRE4 TS101_RAT 4.00E-52 GO:0000813; GO:0007049; GO:0051301; GO:0008333; GO:0031902; GO:0030374; GO:0005634; GO:0006513; GO:0015031; GO:0040008; GO:0043162; GO:0046755 ESCRT I complex; cell cycle; cell division; endosome to lysosome transport; late endosome membrane; ligand-dependent nuclear receptor transcription coactivator activity; nucleus; protein monoubiquitination; protein transport; regulation of growth; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; viral budding IPR017916; IPR016135; IPR008883; Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) Tsg101 Rattus norvegicus (Rat) TR28394_c0_g1_i1 Q8K4M5 COMD1_MOUSE 4.00E-47 GO:0031462; GO:0030054; GO:0006878; GO:0005507; GO:0005737; GO:0032088; GO:0005730; GO:0005634; GO:0031398; GO:0032434 Cul2-RING ubiquitin ligase complex; cell junction; cellular copper ion homeostasis; copper ion binding; cytoplasm; negative regulation of NF-kappaB transcription factor activity; nucleolus; nucleus; positive regulation of protein ubiquitination; regulation of proteasomal ubiquitin-dependent protein catabolic process IPR017920; IPR009886; COMM domain-containing protein 1 (Protein Murr1) Commd1 Murr1 Mus musculus (Mouse) TR28396_c0_g1_i1 P49101 CDPK2_MAIZE 9.00E-11 GO:0005524; GO:0005509; GO:0004674 ATP binding; calcium ion binding; protein serine/threonine kinase activity IPR011992; IPR018247; IPR002048; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium-dependent protein kinase 2 (CDPK 2) (EC 2.7.11.1) CPK2 CDPK2 Zea mays (Maize) TR28396_c0_g1_i2 Q8RWL2 CDPKT_ARATH 8.00E-12 GO:0005524; GO:0005509; GO:0016020; GO:0004674 ATP binding; calcium ion binding; membrane; protein serine/threonine kinase activity IPR011992; IPR018247; IPR002048; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium-dependent protein kinase 29 (EC 2.7.11.1) CPK29 At1g76040 T4O12.25 Arabidopsis thaliana (Mouse-ear cress) TR28398_c1_g1_i2 Q9D8S9 BOLA1_MOUSE 4.00E-31 GO:0005576; GO:0005739 extracellular region; mitochondrion IPR002634; BolA-like protein 1 Bola1 Mus musculus (Mouse) TR28398_c1_g1_i3 Q84W65 SUFE_ARATH 7.00E-14 GO:0009570; GO:0008047; GO:0016226; GO:0005739 chloroplast stroma; enzyme activator activity; iron-sulfur cluster assembly; mitochondrion IPR002634; IPR003808; Cofactor biosynthesis; iron-sulfur cluster biosynthesis. "SufE-like protein, chloroplastic (Protein EMBRYO DEFECTIVE 1374) (Protein SULFUR E) (AtSUFE) (Protein SULFUR E 1) (AtSUFE1)" SUFE EMB1374 SUFE1 At4g26500 M3E9.70 Arabidopsis thaliana (Mouse-ear cress) TR28398_c1_g1_i4 Q5RCE5 BOLA1_PONAB 1.00E-29 GO:0005576; GO:0005739 extracellular region; mitochondrion IPR002634; BolA-like protein 1 BOLA1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR28400_c0_g1_i1 Q99MT2 MSH4_MOUSE 4.00E-47 GO:0005524; GO:0008094; GO:0051026; GO:0007292; GO:0045143; GO:0006298; GO:0030983; GO:0005654; GO:0001541; GO:0007131; GO:0007283; GO:0000795 ATP binding; DNA-dependent ATPase activity; chiasma assembly; female gamete generation; homologous chromosome segregation; mismatch repair; mismatched DNA binding; nucleoplasm; ovarian follicle development; reciprocal meiotic recombination; spermatogenesis; synaptonemal complex IPR000432; IPR007861; IPR007696; IPR007860; IPR027417; MutS protein homolog 4 (mMsh4) Msh4 Mus musculus (Mouse) TR28402_c0_g1_i1 Q91YL3 UCKL1_MOUSE 3.00E-118 GO:0005524; GO:0044206; GO:0005783; GO:0005634; GO:0016773; GO:0004849 "ATP binding; UMP salvage; endoplasmic reticulum; nucleus; phosphotransferase activity, alcohol group as acceptor; uridine kinase activity" IPR027417; IPR006083; IPR000764; Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. Uridine-cytidine kinase-like 1 (EC 2.7.1.-) Uckl1 Urkl1 Mus musculus (Mouse) TR28402_c2_g1_i1 Q55EL3 UCKA_DICDI 1.00E-80 GO:0005524; GO:0044211; GO:0044206; GO:0016773; GO:0008655; GO:0004849 "ATP binding; CTP salvage; UMP salvage; phosphotransferase activity, alcohol group as acceptor; pyrimidine-containing compound salvage; uridine kinase activity" IPR027417; IPR006083; IPR000764; Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. Uridine-cytidine kinase A (EC 2.7.1.48) (Cytidine monophosphokinase A) (Uridine kinase/uracil phosphoribosyltransferase) (UK-UPRT) (Uridine monophosphokinase A) udkA ukuprt DDB_G0269034 Dictyostelium discoideum (Slime mold) TR28403_c0_g1_i1 Q5NC57 F183B_MOUSE 1.00E-27 Protein FAM183B Fam183b Mus musculus (Mouse) TR28409_c0_g1_i1 Q6PB44 PTN23_MOUSE 2.00E-96 GO:0005929; GO:0060271; GO:0016023; GO:0005769; GO:0005932; GO:0005634; GO:0035335; GO:0015031; GO:0004725; GO:0043162 cilium; cilium morphogenesis; cytoplasmic membrane-bounded vesicle; early endosome; microtubule basal body; nucleus; peptidyl-tyrosine dephosphorylation; protein transport; protein tyrosine phosphatase activity; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IPR025304; IPR004328; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) Ptpn23 Kiaa1471 Mus musculus (Mouse) TR28410_c1_g1_i1 A8K855 EFCB7_HUMAN 2.00E-32 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; EF-hand calcium-binding domain-containing protein 7 EFCAB7 KIAA1799 Homo sapiens (Human) TR28410_c6_g2_i2 A8K855 EFCB7_HUMAN 1.00E-30 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; EF-hand calcium-binding domain-containing protein 7 EFCAB7 KIAA1799 Homo sapiens (Human) TR28414_c0_g1_i1 Q07E38 CAV1_NEONE 2.00E-42 GO:0000139; GO:0031295; GO:0005901; GO:0005768 Golgi membrane; T cell costimulation; caveola; endosome IPR001612; IPR015504; IPR018361; Caveolin-1 CAV1 Neofelis nebulosa (Clouded leopard) TR28414_c0_g1_i3 Q94051 CAV1_CAEEL 7.00E-17 GO:0000139; GO:0007265; GO:0005901; GO:0005938; GO:0060473; GO:0005887; GO:0009898; GO:0007126; GO:0048471; GO:0046662; GO:0030133 Golgi membrane; Ras protein signal transduction; caveola; cell cortex; cortical granule; integral to plasma membrane; internal side of plasma membrane; meiosis; perinuclear region of cytoplasm; regulation of oviposition; transport vesicle IPR001612; Caveolin-1 cav-1 T13F2.8 Caenorhabditis elegans TR28416_c0_g1_i1 Q04500 UTP14_YEAST 1.00E-30 GO:0005524; GO:0000480; GO:0000447; GO:0000472; GO:0005730; GO:0032040 "ATP binding; endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleolus; small-subunit processome" IPR006709; U3 small nucleolar RNA-associated protein 14 (U3 snoRNA-associated protein 14) (U three protein 14) UTP14 YML093W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR28416_c0_g1_i2 Q3T0Q8 UT14A_BOVIN 2.00E-42 GO:0005730; GO:0006364; GO:0032040 nucleolus; rRNA processing; small-subunit processome IPR006709; U3 small nucleolar RNA-associated protein 14 homolog A UTP14A Bos taurus (Bovine) TR28419_c3_g1_i1 Q08CY4 TELO2_XENTR 6.00E-37 GO:0000781; GO:0005737; GO:0016020; GO:0005634 "chromosome, telomeric region; cytoplasm; membrane; nucleus" IPR019337; Telomere length regulation protein TEL2 homolog telo2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28419_c4_g1_i1 Q6GPP1 TELO2_XENLA 1.00E-66 GO:0000781; GO:0005737; GO:0016020; GO:0005634 "chromosome, telomeric region; cytoplasm; membrane; nucleus" IPR016024; IPR019337; Telomere length regulation protein TEL2 homolog telo2 Xenopus laevis (African clawed frog) TR28420_c9_g2_i2 O43301 HS12A_HUMAN 2.00E-74 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR28420_c9_g2_i3 Q96MM6 HS12B_HUMAN 6.00E-44 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR28420_c9_g2_i7 O43301 HS12A_HUMAN 4.00E-80 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR28422_c0_g1_i1 Q55E31 RB32B_DICDI 9.00E-59 GO:0005525; GO:0015031; GO:0007264 GTP binding; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-32B rab32B DDB_G0269416 Dictyostelium discoideum (Slime mold) TR28423_c0_g1_i1 P13804 ETFA_HUMAN 2.00E-155 GO:0009055; GO:0050660; GO:0005759; GO:0016491; GO:0022904; GO:0044281 electron carrier activity; flavin adenine dinucleotide binding; mitochondrial matrix; oxidoreductase activity; respiratory electron transport chain; small molecule metabolic process IPR001308; IPR014730; IPR014731; IPR018206; IPR014729; "Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF)" ETFA Homo sapiens (Human) TR28426_c0_g1_i1 Q503Y4 OVCA2_DANRE 2.00E-70 IPR005645; Ovarian cancer-associated gene 2 protein homolog ovca2 zgc:110011 Danio rerio (Zebrafish) (Brachydanio rerio) TR28432_c0_g1_i1 Q6QMZ4 RL6_CHILA 1.00E-79 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000915; IPR014722; IPR005568; IPR008991; 60S ribosomal protein L6 RPL6 Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) TR28434_c0_g1_i1 O43396 TXNL1_HUMAN 5.00E-106 GO:0045454; GO:0005737; GO:0015036; GO:0006662; GO:0005634; GO:0000502; GO:0015035 cell redox homeostasis; cytoplasm; disulfide oxidoreductase activity; glycerol ether metabolic process; nucleus; proteasome complex; protein disulfide oxidoreductase activity IPR008979; IPR010400; IPR005746; IPR012336; IPR017937; IPR013766; Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein) TXNL1 TRP32 TXL TXNL Homo sapiens (Human) TR28434_c0_g1_i2 P25372 TRX3_YEAST 4.00E-17 GO:0045454; GO:0034599; GO:0015036; GO:0006662; GO:0005739; GO:0015035 cell redox homeostasis; cellular response to oxidative stress; disulfide oxidoreductase activity; glycerol ether metabolic process; mitochondrion; protein disulfide oxidoreductase activity IPR005746; IPR012336; IPR017937; IPR013766; "Thioredoxin-3, mitochondrial" TRX3 YCR083W YCR83W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR28438_c0_g1_i1 O74875 YJ83_SCHPO 5.00E-07 GO:0003958; GO:0005737; GO:0020037; GO:0042168; GO:0046872 NADPH-hemoprotein reductase activity; cytoplasm; heme binding; heme metabolic process; metal ion binding IPR001199; Uncharacterized heme-binding protein C330.03c SPCC330.03c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR28438_c0_g2_i1 O04354 CYB5_BOROF 2.00E-21 GO:0005789; GO:0020037; GO:0016021; GO:0046872; GO:0055114 endoplasmic reticulum membrane; heme binding; integral to membrane; metal ion binding; oxidation-reduction process IPR001199; IPR018506; Cytochrome b5 Borago officinalis (Bourrache) (Borage) TR28441_c0_g1_i1 P16368 TIMP2_BOVIN 5.00E-14 GO:0005576; GO:0046872; GO:0008191 extracellular region; metal ion binding; metalloendopeptidase inhibitor activity IPR001134; IPR001820; IPR008993; IPR015613; IPR027465; Metalloproteinase inhibitor 2 (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 2) (TIMP-2) TIMP2 Bos taurus (Bovine) TR28441_c0_g1_i2 Q9WUC6 TIMP2_CAVPO 1.00E-13 GO:0005576; GO:0046872; GO:0008191 extracellular region; metal ion binding; metalloendopeptidase inhibitor activity IPR001134; IPR001820; IPR008993; IPR015613; IPR027465; Metalloproteinase inhibitor 2 (Tissue inhibitor of metalloproteinases 2) (TIMP-2) TIMP2 Cavia porcellus (Guinea pig) TR28443_c1_g1_i1 B8DVU7 RL1_BIFA0 2.00E-07 GO:0015934; GO:0019843; GO:0006417; GO:0003735; GO:0000049; GO:0006412 large ribosomal subunit; rRNA binding; regulation of translation; structural constituent of ribosome; tRNA binding; translation IPR005878; IPR002143; IPR023674; IPR028364; IPR016094; IPR016095; IPR023673; 50S ribosomal protein L1 rplA BLA_0296 Bifidobacterium animalis subsp. lactis (strain AD011) TR28443_c1_g1_i3 O67759 RL1_AQUAE 4.00E-11 GO:0015934; GO:0019843; GO:0006417; GO:0003735; GO:0000049; GO:0006412 large ribosomal subunit; rRNA binding; regulation of translation; structural constituent of ribosome; tRNA binding; translation IPR005878; IPR002143; IPR023674; IPR028364; IPR016094; IPR016095; IPR023673; 50S ribosomal protein L1 rplA aq_1935 Aquifex aeolicus (strain VF5) TR28443_c1_g1_i4 Q99N96 RM01_MOUSE 7.00E-15 GO:0003723; GO:0015934; GO:0005739; GO:0003735; GO:0006412 RNA binding; large ribosomal subunit; mitochondrion; structural constituent of ribosome; translation IPR023674; IPR016094; IPR016095; IPR024663; IPR005879; "39S ribosomal protein L1, mitochondrial (L1mt) (MRP-L1)" Mrpl1 Mus musculus (Mouse) TR28444_c3_g1_i2 B5X3I6 TSN9_SALSA 3.00E-06 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-9 (Tspan-9) tspan9 Salmo salar (Atlantic salmon) TR28448_c0_g2_i1 O45870 NSMA_CAEEL 7.00E-61 GO:0016021; GO:0046872; GO:0006665; GO:0004767 integral to membrane; metal ion binding; sphingolipid metabolic process; sphingomyelin phosphodiesterase activity IPR005135; Lipid metabolism; sphingolipid metabolism. Putative neutral sphingomyelinase (EC 3.1.4.12) T27F6.6 Caenorhabditis elegans TR28448_c0_g2_i2 O45870 NSMA_CAEEL 9.00E-66 GO:0016021; GO:0046872; GO:0006665; GO:0004767 integral to membrane; metal ion binding; sphingolipid metabolic process; sphingomyelin phosphodiesterase activity IPR005135; Lipid metabolism; sphingolipid metabolism. Putative neutral sphingomyelinase (EC 3.1.4.12) T27F6.6 Caenorhabditis elegans TR28450_c0_g1_i1 Q80ZS3 RT26_MOUSE 4.00E-11 GO:0005763; GO:0005739 mitochondrial small ribosomal subunit; mitochondrion IPR026140; "28S ribosomal protein S26, mitochondrial (MRP-S26) (S26mt)" Mrps26 Mus musculus (Mouse) TR28453_c1_g1_i2 Q8BTQ0 PCGF3_MOUSE 1.00E-80 GO:0031519; GO:0006355; GO:0006351; GO:0008270 "PcG protein complex; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR018957; IPR001841; IPR013083; IPR017907; Polycomb group RING finger protein 3 (RING finger protein 3A) PcgF3 Rnf3 Rnf3a Mus musculus (Mouse) TR28453_c1_g1_i4 Q8BTQ0 PCGF3_MOUSE 2.00E-78 GO:0031519; GO:0006355; GO:0006351; GO:0008270 "PcG protein complex; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR018957; IPR001841; IPR013083; IPR017907; Polycomb group RING finger protein 3 (RING finger protein 3A) PcgF3 Rnf3 Rnf3a Mus musculus (Mouse) TR28460_c0_g3_i1 Q9D5V6 SYAP1_MOUSE 2.00E-49 GO:0005634 nucleus IPR005607; Synapse-associated protein 1 Syap1 Mus musculus (Mouse) TR28460_c0_g3_i3 Q960T2 SAP47_DROME 2.00E-36 GO:0008306; GO:0048172; GO:0045202; GO:0007268 associative learning; regulation of short-term neuronal synaptic plasticity; synapse; synaptic transmission IPR005607; Synapse-associated protein of 47 kDa Sap47 CG8884 Drosophila melanogaster (Fruit fly) TR28460_c0_g3_i5 Q9D5V6 SYAP1_MOUSE 4.00E-47 GO:0005634 nucleus IPR005607; Synapse-associated protein 1 Syap1 Mus musculus (Mouse) TR28465_c0_g1_i1 Q9P7A1 PITH1_SCHPO 3.00E-29 GO:0005829; GO:0005634; GO:0010498 cytosol; nucleus; proteasomal protein catabolic process IPR008979; IPR010400; PITH domain-containing protein P35G2.02 SPBP35G2.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR28465_c0_g1_i2 Q29L80 PITH1_DROPS 1.00E-84 IPR008979; IPR010400; PITH domain-containing protein GA19395 GA19395 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR28467_c6_g2_i1 Q61084 M3K3_MOUSE 4.00E-10 GO:0005524; GO:0004709; GO:0000165; GO:0000186; GO:0046872; GO:0046777; GO:0004672 Q9WVS7; P70196 ATP binding; MAP kinase kinase kinase activity; MAPK cascade; activation of MAPKK activity; metal ion binding; protein autophosphorylation; protein kinase activity IPR011009; IPR000270; IPR000719; IPR002290; Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Map3k3 Mekk3 Mus musculus (Mouse) TR28467_c6_g2_i2 Q61084 M3K3_MOUSE 2.00E-10 GO:0005524; GO:0004709; GO:0000165; GO:0000186; GO:0046872; GO:0046777; GO:0004672 Q9WVS7; P70196 ATP binding; MAP kinase kinase kinase activity; MAPK cascade; activation of MAPKK activity; metal ion binding; protein autophosphorylation; protein kinase activity IPR011009; IPR000270; IPR000719; IPR002290; Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Map3k3 Mekk3 Mus musculus (Mouse) TR28471_c0_g1_i1 Q6AY85 ALG14_RAT 4.00E-63 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR013969; UDP-N-acetylglucosamine transferase subunit ALG14 homolog Alg14 Rattus norvegicus (Rat) TR28476_c3_g1_i1 Q10311 YD58_SCHPO 3.00E-12 GO:0005829; GO:0005634; GO:0043161; GO:0005838 cytosol; nucleus; proteasomal ubiquitin-dependent protein catabolic process; proteasome regulatory particle IPR002110; IPR020683; Ankyrin repeat-containing protein C6C3.08 SPAC6C3.08 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR28476_c4_g1_i1 Q08DV6 ASB3_BOVIN 1.00E-10 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 3 (ASB-3) ASB3 Bos taurus (Bovine) TR28476_c5_g1_i1 C8YR32 LOXH1_MOUSE 4.00E-17 GO:0005262; GO:0050982; GO:0016020; GO:0007605; GO:0032420 calcium channel activity; detection of mechanical stimulus; membrane; sensory perception of sound; stereocilium IPR008976; IPR001024; Lipoxygenase homology domain-containing protein 1 Loxhd1 Mus musculus (Mouse) TR28478_c0_g1_i1 Q9CQM5 TXD17_MOUSE 2.00E-19 GO:0005829; GO:0009055; GO:0004601; GO:0047134; GO:0033209 cytosol; electron carrier activity; peroxidase activity; protein-disulfide reductase activity; tumor necrosis factor-mediated signaling pathway IPR010357; IPR012336; Thioredoxin domain-containing protein 17 (14 kDa thioredoxin-related protein) (TRP14) (Protein 42-9-9) (Thioredoxin-like protein 5) Txndc17 Txnl5 Mus musculus (Mouse) TR28478_c0_g2_i1 Q9CQM5 TXD17_MOUSE 2.00E-19 GO:0005829; GO:0009055; GO:0004601; GO:0047134; GO:0033209 cytosol; electron carrier activity; peroxidase activity; protein-disulfide reductase activity; tumor necrosis factor-mediated signaling pathway IPR010357; IPR012336; Thioredoxin domain-containing protein 17 (14 kDa thioredoxin-related protein) (TRP14) (Protein 42-9-9) (Thioredoxin-like protein 5) Txndc17 Txnl5 Mus musculus (Mouse) TR28482_c2_g1_i1 P63100 CANB1_RAT 3.00E-61 GO:0005509; GO:0005829; GO:0004721; GO:0006470 calcium ion binding; cytosol; phosphoprotein phosphatase activity; protein dephosphorylation IPR011992; IPR018247; IPR002048; Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1) Ppp3r1 Cna2 Cnb Rattus norvegicus (Rat) TR28483_c0_g1_i1 Q04786 HEX_VIBVL 7.00E-26 GO:0004563; GO:0006032; GO:0030247; GO:0000272 beta-N-acetylhexosaminidase activity; chitin catabolic process; polysaccharide binding; polysaccharide catabolic process IPR025705; IPR008965; IPR012291; IPR004866; IPR013812; IPR015883; IPR015882; IPR013781; IPR017853; IPR014756; Glycan degradation; chitin degradation. Beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Chitobiase) (N-acetyl-beta-glucosaminidase) hex Vibrio vulnificus TR28483_c2_g1_i1 P86956 HEX_PINMA 8.00E-27 GO:0004563; GO:0005975; GO:0006032; GO:0005576; GO:0030247 beta-N-acetylhexosaminidase activity; carbohydrate metabolic process; chitin catabolic process; extracellular region; polysaccharide binding IPR025705; IPR008965; IPR012291; IPR004866; IPR015883; IPR013781; IPR017853; Glycan degradation; chitin degradation. Putative beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Chitobiase) (N-acetyl-beta-glucosaminidase) Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) TR28483_c3_g1_i1 Q54468 CHB_SERMA 7.00E-43 GO:0004563; GO:0006032; GO:0042597; GO:0030247; GO:0000272 beta-N-acetylhexosaminidase activity; chitin catabolic process; periplasmic space; polysaccharide binding; polysaccharide catabolic process IPR025705; IPR008965; IPR012291; IPR004866; IPR004867; IPR013812; IPR015883; IPR015882; IPR013781; IPR017853; IPR014756; Glycan degradation; chitin degradation. Chitobiase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (N-acetyl-beta-glucosaminidase) chb Serratia marcescens TR28485_c0_g1_i1 Q641S2 OPA3_XENLA 4.00E-14 GO:0005739 mitochondrion IPR010754; Optic atrophy 3 protein homolog opa3 Xenopus laevis (African clawed frog) TR28488_c0_g1_i1 Q9CXS4 CENPV_MOUSE 2.00E-61 GO:0001667; GO:0016846; GO:0051301; GO:0031508; GO:0000777; GO:0005737; GO:0000776; GO:0007067; GO:0005634; GO:0032467; GO:0033044; GO:0051233 ameboidal cell migration; carbon-sulfur lyase activity; cell division; centromeric heterochromatin assembly; condensed chromosome kinetochore; cytoplasm; kinetochore; mitosis; nucleus; positive regulation of cytokinesis; regulation of chromosome organization; spindle midzone IPR006913; IPR011057; Centromere protein V (CENP-V) (Proline-rich protein 6) Cenpv Prr6 Mus musculus (Mouse) TR28488_c0_g1_i2 Q9CXS4 CENPV_MOUSE 5.00E-61 GO:0001667; GO:0016846; GO:0051301; GO:0031508; GO:0000777; GO:0005737; GO:0000776; GO:0007067; GO:0005634; GO:0032467; GO:0033044; GO:0051233 ameboidal cell migration; carbon-sulfur lyase activity; cell division; centromeric heterochromatin assembly; condensed chromosome kinetochore; cytoplasm; kinetochore; mitosis; nucleus; positive regulation of cytokinesis; regulation of chromosome organization; spindle midzone IPR006913; IPR011057; Centromere protein V (CENP-V) (Proline-rich protein 6) Cenpv Prr6 Mus musculus (Mouse) TR28489_c0_g1_i2 Q9BGT1 TTC9C_MACFA 2.00E-30 IPR023566; IPR013026; IPR011990; IPR013105; IPR019734; Tetratricopeptide repeat protein 9C (TPR repeat protein 9C) TTC9C QflA-13179 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR2849_c0_g1_i1 Q76B49 CD63_FELCA 1.00E-07 GO:0009986; GO:0034613; GO:0016021; GO:0031902; GO:0005765; GO:0005886; GO:2000680 cell surface; cellular protein localization; integral to membrane; late endosome membrane; lysosomal membrane; plasma membrane; regulation of rubidium ion transport IPR000301; IPR018499; IPR018503; IPR008952; CD63 antigen (CD antigen CD63) CD63 Felis catus (Cat) (Felis silvestris catus) TR28494_c2_g1_i2 Q54NW1 OPA3_DICDI 5.00E-12 IPR010754; OPA3-like protein DDB_G0284959 Dictyostelium discoideum (Slime mold) TR28494_c2_g1_i4 Q1L9A2 OPA3_DANRE 8.00E-13 GO:0007626; GO:0005739; GO:0050881; GO:0031413 locomotory behavior; mitochondrion; musculoskeletal movement; regulation of buoyancy IPR010754; Optic atrophy 3 protein homolog opa3 si:dkey-12o15.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR285_c0_g1_i1 Q5PR73 DIRA2_MOUSE 4.00E-33 GO:0005525; GO:0003924; GO:0005886; GO:0007264 GTP binding; GTPase activity; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; GTP-binding protein Di-Ras2 (Distinct subgroup of the Ras family member 2) Diras2 Mus musculus (Mouse) TR28501_c0_g2_i1 O94673 YG75_SCHPO 2.00E-17 GO:0005794; GO:0000139; GO:0015144; GO:0005783; GO:0005789; GO:0016021 Golgi apparatus; Golgi membrane; carbohydrate transmembrane transporter activity; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane IPR021261; Uncharacterized membrane protein C776.05 SPBC776.05 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR28502_c0_g1_i1 Q9UT45 ENG1_SCHPO 4.00E-15 GO:0043187; GO:0009986; GO:0016998; GO:0046379; GO:0042973; GO:0052861; GO:0052862; GO:0009313; GO:0030247; GO:0030994 "cell septum surface; cell surface; cell wall macromolecule catabolic process; extracellular polysaccharide metabolic process; glucan endo-1,3-beta-D-glucosidase activity; glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group; glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group; oligosaccharide catabolic process; polysaccharide binding; primary cell septum disassembly" IPR018909; IPR005200; "Endo-1,3(4)-beta-glucanase 1 (Endo-1,3-beta-glucanase 1) (Endo-1,4-beta-glucanase 1) (EC 3.2.1.6) (Laminarinase-1)" eng1 SPAC821.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR28503_c0_g1_i1 Q8K354 CBR3_MOUSE 9.00E-74 GO:0070402; GO:0004090; GO:0005829; GO:0005634 NADPH binding; carbonyl reductase (NADPH) activity; cytosol; nucleus IPR002198; IPR002347; IPR016040; IPR020904; Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) Cbr3 Mus musculus (Mouse) TR28503_c0_g1_i2 A6QP05 DHR12_BOVIN 8.00E-09 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; Dehydrogenase/reductase SDR family member 12 (EC 1.1.-.-) DHRS12 Bos taurus (Bovine) TR28505_c0_g1_i1 Q58D00 FBXW2_BOVIN 1.00E-44 IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) FBXW2 Bos taurus (Bovine) TR28512_c3_g1_i1 Q14590 ZN235_HUMAN 8.00E-39 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) TR28512_c3_g1_i10 P13360 GLAS_DROME 5.00E-35 GO:0003677; GO:0003705; GO:0001752; GO:0043153; GO:0046872; GO:0005634; GO:0045944; GO:0010114; GO:0035271; GO:0007605; GO:0007601 DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; compound eye photoreceptor fate commitment; entrainment of circadian clock by photoperiod; metal ion binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; response to red light; ring gland development; sensory perception of sound; visual perception IPR007087; IPR015880; IPR013087; Protein glass gl CG7672 Drosophila melanogaster (Fruit fly) TR28512_c3_g1_i11 Q1L8W0 ZN238_DANRE 1.00E-17 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 18 (Zinc finger protein 238) zbtb18 znf238 si:ch211-221n23.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR28512_c3_g1_i2 Q923B3 NRIF1_MOUSE 1.00E-28 GO:0005829; GO:0097191; GO:0046872; GO:0051402; GO:0005634; GO:0046328; GO:1990009; GO:0043565; GO:0000981 cytosol; extrinsic apoptotic signaling pathway; metal ion binding; neuron apoptotic process; nucleus; regulation of JNK cascade; retinal cell apoptotic process; sequence-specific DNA binding; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Neurotrophin receptor-interacting factor 1 (Neurotrophin receptor-interacting factor) (Zinc finger protein 110) Nrif1 Nrif Zfp110 Mus musculus (Mouse) TR28512_c3_g1_i3 Q9Y467 SALL2_HUMAN 6.00E-16 GO:0003677; GO:0016581; GO:0046872; GO:0000122; GO:0021915; GO:0005634; GO:0003700; GO:0006351 P08138 "DNA binding; NuRD complex; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; neural tube development; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Sal-like protein 2 (Zinc finger protein 795) (Zinc finger protein SALL2) (Zinc finger protein Spalt-2) (Sal-2) (hSal2) SALL2 KIAA0360 SAL2 ZNF795 Homo sapiens (Human) TR28512_c3_g1_i4 A6NGD5 ZSA5C_HUMAN 3.00E-32 GO:0046872; GO:0003676; GO:0005634; GO:0000981 metal ion binding; nucleic acid binding; nucleus; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 5C ZSCAN5C Homo sapiens (Human) TR28512_c3_g1_i5 Q60636 PRDM1_MOUSE 1.00E-40 GO:0003677; GO:0045165; GO:0005737; GO:0042462; GO:0007281; GO:0042826; GO:0001893; GO:0046872; GO:0008168; GO:0007275; GO:0030889; GO:0031665; GO:0000122; GO:0005634; GO:0045579; GO:0010628; GO:0006355; GO:0043565; GO:0006351; GO:0060707 P63165 "DNA binding; cell fate commitment; cytoplasm; eye photoreceptor cell development; germ cell development; histone deacetylase binding; maternal placenta development; metal ion binding; methyltransferase activity; multicellular organismal development; negative regulation of B cell proliferation; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of B cell differentiation; positive regulation of gene expression; regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription, DNA-dependent; trophoblast giant cell differentiation" IPR001214; IPR007087; IPR015880; IPR013087; IPR016608; PR domain zinc finger protein 1 (EC 2.1.1.-) (B lymphocyte-induced maturation protein 1) (Blimp-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) Prdm1 Blimp1 Mus musculus (Mouse) TR28512_c3_g1_i8 Q5EBM4 ZN542_HUMAN 2.00E-11 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Putative zinc finger protein 542 ZNF542 Homo sapiens (Human) TR28512_c3_g2_i1 A6NK53 ZN233_HUMAN 3.00E-43 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 233 ZNF233 Homo sapiens (Human) TR28512_c4_g1_i1 Q9UTA1 YL8J_SCHPO 8.00E-11 GO:0000978; GO:0046872; GO:0005634; GO:0006357 RNA polymerase II core promoter proximal region sequence-specific DNA binding; metal ion binding; nucleus; regulation of transcription from RNA polymerase II promoter IPR007087; IPR015880; IPR013087; Zinc finger protein C25B8.19c SPAC25B8.19c SPAC683.01c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR28514_c0_g1_i1 Q32PH0 TPPC9_BOVIN 4.00E-59 GO:0005794; GO:0030154; GO:0005783 Golgi apparatus; cell differentiation; endoplasmic reticulum IPR013935; Trafficking protein particle complex subunit 9 (NIK- and IKBKB-binding protein) TRAPPC9 NIBP Bos taurus (Bovine) TR28514_c0_g2_i2 Q9VIL0 BRU_DROME 1.00E-31 GO:0036063; GO:0000916; GO:0007112; GO:0007110; GO:0007111; GO:0043147; GO:0048137 acroblast; actomyosin contractile ring contraction; male meiosis cytokinesis; meiosis I cytokinesis; meiosis II cytokinesis; meiotic spindle stabilization; spermatocyte division IPR013935; Protein brunelleschi (NIK- and IKBKB-binding protein) bru CG2478 Drosophila melanogaster (Fruit fly) TR28515_c2_g1_i1 P62749 HPCL1_RAT 2.00E-23 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Hippocalcin-like protein 1 (Neural visinin-like protein 3) (NVL-3) (NVP-3) (Visinin-like protein 3) (VILIP-3) Hpcal1 Rattus norvegicus (Rat) TR28515_c3_g1_i1 Q16982 NECX_APLCA 6.00E-39 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Neurocalcin Aplysia californica (California sea hare) TR28521_c2_g2_i1 Q6DIN3 MBTD1_XENTR 5.00E-146 GO:0016568; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR004092; IPR012313; MBT domain-containing protein 1 mbtd1 TTpA012c17.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28522_c0_g1_i1 P41755 DHE2_ACHKL 1.00E-12 GO:0004352 glutamate dehydrogenase (NAD+) activity IPR019651; NAD-specific glutamate dehydrogenase (NAD-GDH) (EC 1.4.1.2) Achlya klebsiana TR28522_c0_g1_i3 P02826 HSP7A_DROSI 4.00E-46 GO:0005524; GO:0006950 ATP binding; response to stress IPR018181; IPR013126; Heat shock 70 kDa protein cognate 1 (Heat shock 70 kDa protein 70C) (Fragments) Hsc70-1 Hsc1 Drosophila simulans (Fruit fly) TR28522_c0_g1_i4 O06942 DNAK_STRMU 9.00E-12 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK SMU_82 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) TR28528_c1_g1_i1 O75897 ST1C4_HUMAN 2.00E-19 GO:0050427; GO:0005829; GO:0051923; GO:0008146; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; cytosol; sulfation; sulfotransferase activity; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.-) (Sulfotransferase 1C2) (SULT1C#2) SULT1C4 SULT1C2 Homo sapiens (Human) TR28528_c1_g2_i1 P19217 ST1E1_BOVIN 2.00E-19 GO:0005737; GO:0008210; GO:0004304; GO:0005496; GO:0050294 cytoplasm; estrogen metabolic process; estrone sulfotransferase activity; steroid binding; steroid sulfotransferase activity IPR027417; IPR000863; "Estrogen sulfotransferase (EC 2.8.2.4) (Sulfotransferase 1E1) (ST1E1) (Sulfotransferase, estrogen-preferring)" SULT1E1 OST STE Bos taurus (Bovine) TR28529_c0_g1_i2 A4K526 CQ061_BUFGR 8.00E-30 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR006696; Transmembrane protein 256 homolog Bufo gargarizans (Asian toad) (Bufo bufo gargarizans) TR28529_c0_g1_i3 Q568J8 CQ061_DANRE 2.00E-23 GO:0016021 integral to membrane IPR006696; Transmembrane protein 256 tmem256 zgc:110256 Danio rerio (Zebrafish) (Brachydanio rerio) TR28530_c1_g1_i1 Q9XTQ6 TBH1_CAEEL 3.00E-45 GO:0006584; GO:0030054; GO:0005507; GO:0004500; GO:0042136; GO:0045202; GO:0008021 catecholamine metabolic process; cell junction; copper ion binding; dopamine beta-monooxygenase activity; neurotransmitter biosynthetic process; synapse; synaptic vesicle IPR014784; IPR020611; IPR000323; IPR000945; IPR005018; IPR008977; Tyramine beta-hydroxylase (EC 1.14.17.-) tbh-1 H13N06.6 Caenorhabditis elegans TR28533_c0_g1_i1 Q9UAS2 FABP1_FASGI 4.00E-07 GO:0008289; GO:0005215 lipid binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; Fatty acid-binding protein 1 FABP-1 Fasciola gigantica (Giant liver fluke) TR28534_c1_g1_i1 P0CN26 DPOE_CRYNJ 7.00E-38 GO:0051539; GO:0003677; GO:0006260; GO:0003887; GO:0000166; GO:0005634; GO:0008270 "4 iron, 4 sulfur cluster binding; DNA binding; DNA replication; DNA-directed DNA polymerase activity; nucleotide binding; nucleus; zinc ion binding" IPR006172; IPR006133; IPR006134; IPR013697; IPR012337; DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A) POL2 CNK01430 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR28534_c1_g1_i2 Q9WVF7 DPOE1_MOUSE 5.00E-145 GO:0051539; GO:0003677; GO:0006260; GO:0000731; GO:0003887; GO:0000082; GO:0006287; GO:0003682; GO:0008622; GO:0000166; GO:0006297; GO:0008270 "4 iron, 4 sulfur cluster binding; DNA binding; DNA replication; DNA synthesis involved in DNA repair; DNA-directed DNA polymerase activity; G1/S transition of mitotic cell cycle; base-excision repair, gap-filling; chromatin binding; epsilon DNA polymerase complex; nucleotide binding; nucleotide-excision repair, DNA gap filling; zinc ion binding" IPR006172; IPR006133; IPR006134; IPR013697; IPR012337; DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A) Pole Pole1 Mus musculus (Mouse) TR28534_c1_g2_i1 Q6C4J0 DPOE_YARLI 7.00E-15 GO:0051539; GO:0003677; GO:0006260; GO:0003887; GO:0000166; GO:0005634; GO:0008270 "4 iron, 4 sulfur cluster binding; DNA binding; DNA replication; DNA-directed DNA polymerase activity; nucleotide binding; nucleus; zinc ion binding" IPR006172; IPR006133; IPR006134; IPR013697; IPR012337; DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A) POL2 YALI0E26367g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR28539_c0_g2_i1 Q9PU85 PIM3_COTJA 8.00E-107 GO:0005524; GO:0005737; GO:0004674 ATP binding; cytoplasm; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase pim-3 (EC 2.7.11.1) (qpim) PIM3 PIM-3 Coturnix coturnix japonica (Japanese quail) (Coturnix japonica) TR28541_c5_g1_i2 Q63HN8 RN213_HUMAN 2.00E-11 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR018957; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) TR28541_c8_g1_i1 E9Q555 RN213_MOUSE 3.00E-36 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) Rnf213 Mus musculus (Mouse) TR28546_c0_g2_i4 Q62318 TIF1B_MOUSE 1.00E-05 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0003713; GO:0003714; GO:0006351; GO:0004842; GO:0008270 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; transcription coactivator activity; transcription corepressor activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-A-interacting protein) (KRIP-1) (Tripartite motif-containing protein 28) Trim28 Krip1 Tif1b Mus musculus (Mouse) TR28547_c2_g1_i1 Q7ZXH3 TAB3_XENLA 5.00E-06 GO:0008270 zinc ion binding IPR003892; IPR001876; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 homolog map3k7ip3 Xenopus laevis (African clawed frog) TR28547_c2_g1_i2 Q5RFW2 TAB2_DANRE 5.00E-12 GO:0060027; GO:0007507; GO:0008270 convergent extension involved in gastrulation; heart development; zinc ion binding IPR003892; IPR001876; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TGF-beta-activated kinase 1-binding protein 2) tab2 map3k7ip2 zgc:77446 Danio rerio (Zebrafish) (Brachydanio rerio) TR28547_c2_g4_i1 Q99K90 TAB2_MOUSE 3.00E-12 GO:0070530; GO:0005829; GO:0007507; GO:0005654; GO:0043123; GO:0045860; GO:0008270 Q62073; P62991 K63-linked polyubiquitin binding; cytosol; heart development; nucleoplasm; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein kinase activity; zinc ion binding IPR003892; IPR001876; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) Tab2 Kiaa0733 Map3k7ip2 Mus musculus (Mouse) TR28548_c1_g1_i1 Q60547 SYCP3_MESAU 7.00E-52 GO:0000775; GO:0005634 "chromosome, centromeric region; nucleus" IPR006888; Synaptonemal complex protein 3 (SCP-3) (Meiotic chromosome core protein) (Synaptonemal complex protein COR1) SYCP3 COR1 Mesocricetus auratus (Golden hamster) TR2855_c0_g1_i1 P24823 PPBN_MOUSE 2.00E-07 GO:0004035; GO:0031225; GO:0046872; GO:0030016; GO:0005886 alkaline phosphatase activity; anchored to membrane; metal ion binding; myofibril; plasma membrane IPR017849; IPR001952; IPR018299; IPR017850; "Alkaline phosphatase, placental-like (EAP) (Embryonic alkaline phosphatase) (EC 3.1.3.1) (Alkaline phosphatase 5) (Embryonic-type alkaline phosphatase)" Alppl2 Akp5 Eap Mus musculus (Mouse) TR28550_c2_g1_i1 Q9GK12 PGRP1_CAMDR 2.00E-43 GO:0008745; GO:0042742; GO:0005576; GO:0045087; GO:0042834; GO:0009253; GO:0008270 N-acetylmuramoyl-L-alanine amidase activity; defense response to bacterium; extracellular region; innate immune response; peptidoglycan binding; peptidoglycan catabolic process; zinc ion binding IPR002502; IPR017331; IPR015510; IPR006619; Peptidoglycan recognition protein 1 (Peptidoglycan recognition protein short) (PGRP-S) PGLYRP1 PGLYRP PGRP Camelus dromedarius (Dromedary) (Arabian camel) TR28551_c1_g1_i1 Q66H95 DIRC2_RAT 5.00E-13 GO:0016021; GO:0005765; GO:0055085 integral to membrane; lysosomal membrane; transmembrane transport IPR011701; IPR016196; Disrupted in renal carcinoma protein 2 homolog Dirc2 Rattus norvegicus (Rat) TR28551_c1_g2_i1 Q6GNV7 DIRC2_XENLA 2.00E-19 GO:0016021; GO:0005765; GO:0055085 integral to membrane; lysosomal membrane; transmembrane transport IPR011701; IPR016196; Disrupted in renal carcinoma protein 2 homolog dirc2 Xenopus laevis (African clawed frog) TR28554_c0_g2_i1 Q5R6J1 S6A19_PONAB 9.00E-92 GO:0006865; GO:0005887; GO:0005328 amino acid transport; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR002438; Sodium-dependent neutral amino acid transporter B(0)AT1 (Solute carrier family 6 member 19) (System B(0) neutral amino acid transporter AT1) SLC6A19 B0AT1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR28554_c0_g2_i2 Q9GZN6 S6A16_HUMAN 2.00E-18 GO:0016021; GO:0005622; GO:0005326; GO:0005328 integral to membrane; intracellular; neurotransmitter transporter activity; neurotransmitter:sodium symporter activity IPR000175; Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 (Solute carrier family 6 member 16) SLC6A16 NTT5 Homo sapiens (Human) TR28554_c0_g2_i3 Q9Y345 SC6A5_HUMAN 0 GO:0015375; GO:0016021; GO:0005328; GO:0005886; GO:0007268 glycine:sodium symporter activity; integral to membrane; neurotransmitter:sodium symporter activity; plasma membrane; synaptic transmission IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) TR28557_c1_g1_i1 Q28596 TRFR_SHEEP 4.00E-08 GO:0016021; GO:0005886; GO:0004997 integral to membrane; plasma membrane; thyrotropin-releasing hormone receptor activity IPR000276; IPR017452; IPR002120; Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor) TRHR Ovis aries (Sheep) TR28559_c1_g1_i1 Q6DEY8 WDR67_XENTR 0 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; IPR015943; IPR001680; IPR019775; IPR017986; TBC1 domain family member 31 (WD repeat-containing protein 67) tbc1d31 wdr67 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28559_c3_g1_i1 Q6NXY1 WDR67_MOUSE 4.00E-100 GO:0005097; GO:0005813; GO:0032851 Rab GTPase activator activity; centrosome; positive regulation of Rab GTPase activity IPR000195; IPR015943; IPR001680; IPR019775; IPR017986; TBC1 domain family member 31 (Protein 4-B-3) (WD repeat-containing protein 67) Tbc1d31 Wdr67 Mus musculus (Mouse) TR28562_c6_g1_i1 A4IID4 PI4KB_XENTR 1.00E-169 GO:0004430; GO:0005524; GO:0005741; GO:0006661; GO:0048015; GO:0030867 1-phosphatidylinositol 4-kinase activity; ATP binding; mitochondrial outer membrane; phosphatidylinositol biosynthetic process; phosphatidylinositol-mediated signaling; rough endoplasmic reticulum membrane IPR011009; IPR027003; IPR000403; IPR018936; IPR015433; IPR001263; Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) pi4kb pik4cb Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28564_c8_g1_i1 Q9GZR1 SENP6_HUMAN 2.00E-43 GO:0016929; GO:0005737; GO:0005634; GO:0016926; GO:0016925; GO:0006508; GO:0090234; GO:0090169 SUMO-specific protease activity; cytoplasm; nucleus; protein desumoylation; protein sumoylation; proteolysis; regulation of kinetochore assembly; regulation of spindle assembly IPR003653; Protein modification; protein sumoylation. Sentrin-specific protease 6 (EC 3.4.22.68) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) SENP6 KIAA0797 SSP1 SUSP1 FKSG6 Homo sapiens (Human) TR28567_c0_g1_i1 P0A962 ASPG1_ECOLI 2.00E-59 GO:0004067; GO:0033345; GO:0005737; GO:0042802 asparaginase activity; asparagine catabolic process via L-aspartate; cytoplasm; identical protein binding IPR006033; IPR006034; IPR020827; IPR027475; IPR027473; IPR027474; L-asparaginase 1 (EC 3.5.1.1) (L-asparaginase I) (L-ASNase I) (L-asparagine amidohydrolase I) ansA b1767 JW1756 Escherichia coli (strain K12) TR28567_c1_g1_i1 Q9U518 ASPG_DIRIM 3.00E-94 GO:0004067; GO:0006528 asparaginase activity; asparagine metabolic process IPR002110; IPR020683; IPR006033; IPR006034; IPR020827; IPR027475; IPR027473; IPR027474; L-asparaginase (EC 3.5.1.1) (DiAsp) (L-asparagine amidohydrolase) Dirofilaria immitis (Canine heartworm) TR28567_c1_g1_i2 Q9U518 ASPG_DIRIM 1.00E-53 GO:0004067; GO:0006528 asparaginase activity; asparagine metabolic process IPR002110; IPR020683; IPR006033; IPR006034; IPR020827; IPR027475; IPR027473; IPR027474; L-asparaginase (EC 3.5.1.1) (DiAsp) (L-asparagine amidohydrolase) Dirofilaria immitis (Canine heartworm) TR28569_c1_g1_i1 Q05685 FOLR2_MOUSE 3.00E-49 GO:0031225; GO:0005542; GO:0008517; GO:0005886; GO:0006620 anchored to membrane; folic acid binding; folic acid transporter activity; plasma membrane; posttranslational protein targeting to membrane IPR004269; IPR018143; Folate receptor beta (FR-beta) (Folate receptor 2) (Folate-binding protein 2) Folr2 Fbp2 Folbp2 Mus musculus (Mouse) TR28572_c0_g2_i1 Q9JJK2 LANC2_MOUSE 4.00E-136 GO:0003824; GO:0030864; GO:0005829; GO:0008152; GO:0045892; GO:0005634; GO:0032266; GO:0070273; GO:0010314; GO:0005886; GO:0009789 "catalytic activity; cortical actin cytoskeleton; cytosol; metabolic process; negative regulation of transcription, DNA-dependent; nucleus; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; plasma membrane; positive regulation of abscisic acid mediated signaling pathway" IPR012341; IPR007822; IPR020464; LanC-like protein 2 (Testis-specific adriamycin sensitivity protein) Lancl2 Tasp Mus musculus (Mouse) TR28572_c0_g2_i2 Q9JJK2 LANC2_MOUSE 5.00E-74 GO:0003824; GO:0030864; GO:0005829; GO:0008152; GO:0045892; GO:0005634; GO:0032266; GO:0070273; GO:0010314; GO:0005886; GO:0009789 "catalytic activity; cortical actin cytoskeleton; cytosol; metabolic process; negative regulation of transcription, DNA-dependent; nucleus; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; plasma membrane; positive regulation of abscisic acid mediated signaling pathway" IPR012341; IPR007822; IPR020464; LanC-like protein 2 (Testis-specific adriamycin sensitivity protein) Lancl2 Tasp Mus musculus (Mouse) TR28578_c0_g1_i1 Q96MT7 WDR52_HUMAN 3.00E-32 IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 52 WDR52 Homo sapiens (Human) TR28579_c0_g1_i1 Q8BZ20 PAR12_MOUSE 2.00E-35 GO:0003950; GO:0046872; GO:0005634 NAD+ ADP-ribosyltransferase activity; metal ion binding; nucleus IPR012317; IPR004170; IPR000571; Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) Parp12 Zc3hdc1 Mus musculus (Mouse) TR28580_c0_g1_i2 Q8VE95 CH082_MOUSE 1.00E-68 GO:0005739 mitochondrion IPR028108; UPF0598 protein C8orf82 homolog Mus musculus (Mouse) TR28581_c0_g1_i1 Q6IWZ0 OXLA_APLCA 4.00E-69 GO:0001716; GO:0042742; GO:0050832; GO:0005576; GO:0031640 L-amino-acid oxidase activity; defense response to bacterium; defense response to fungus; extracellular region; killing of cells of other organism IPR002937; L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) (Escapin) Aplysia californica (California sea hare) TR28583_c2_g1_i1 Q32LL2 STML2_BOVIN 3.00E-133 GO:0035710; GO:0050852; GO:1901612; GO:0006874; GO:0019897; GO:0032623; GO:0010876; GO:0045121; GO:0042776; GO:0006851; GO:0005743; GO:0005758; GO:0034982; GO:1900210; GO:0090297; GO:0010918; GO:0051259; GO:1990046 "CD4-positive, alpha-beta T cell activation; T cell receptor signaling pathway; cardiolipin binding; cellular calcium ion homeostasis; extrinsic to plasma membrane; interleukin-2 production; lipid localization; membrane raft; mitochondrial ATP synthesis coupled proton transport; mitochondrial calcium ion transport; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial protein processing; positive regulation of cardiolipin metabolic process; positive regulation of mitochondrial DNA replication; positive regulation of mitochondrial membrane potential; protein oligomerization; stress-induced mitochondrial fusion" IPR001107; IPR001972; "Stomatin-like protein 2, mitochondrial (SLP-2)" STOML2 Bos taurus (Bovine) TR28584_c0_g1_i1 Q5RCU3 NAPEP_PONAB 1.00E-118 GO:0070290; GO:0016020; GO:0009395; GO:0008270 NAPE-specific phospholipase D activity; membrane; phospholipid catabolic process; zinc ion binding IPR001279; IPR024884; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (N-acyl phosphatidylethanolamine phospholipase D) (NAPE-PLD) (NAPE-hydrolyzing phospholipase D) (EC 3.1.4.54) NAPEPLD Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR28584_c0_g1_i4 Q5RCU3 NAPEP_PONAB 4.00E-119 GO:0070290; GO:0016020; GO:0009395; GO:0008270 NAPE-specific phospholipase D activity; membrane; phospholipid catabolic process; zinc ion binding IPR001279; IPR024884; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (N-acyl phosphatidylethanolamine phospholipase D) (NAPE-PLD) (NAPE-hydrolyzing phospholipase D) (EC 3.1.4.54) NAPEPLD Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR28586_c3_g1_i1 Q93075 TATD2_HUMAN 1.00E-09 GO:0006987; GO:0044267; GO:0016888; GO:0046872; GO:0090305; GO:0005654 "activation of signaling protein activity involved in unfolded protein response; cellular protein metabolic process; endodeoxyribonuclease activity, producing 5'-phosphomonoesters; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleoplasm" IPR018228; IPR001130; Putative deoxyribonuclease TATDN2 (EC 3.1.21.-) TATDN2 KIAA0218 Homo sapiens (Human) TR28587_c0_g1_i1 Q10981 FUT2_HUMAN 7.00E-36 GO:0032580; GO:0042355; GO:0008107; GO:0030173; GO:0006486 Golgi cisterna membrane; L-fucose catabolic process; galactoside 2-alpha-L-fucosyltransferase activity; integral to Golgi membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (SE2) (Secretor blood group alpha-2-fucosyltransferase) (Secretor factor) (Se)" FUT2 SEC2 Homo sapiens (Human) TR28589_c1_g1_i2 O43301 HS12A_HUMAN 7.00E-65 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR28590_c0_g1_i3 O60494 CUBN_HUMAN 6.00E-06 GO:0005794; GO:0016324; GO:0031526; GO:0005509; GO:0008203; GO:0005905; GO:0031419; GO:0009235; GO:0015889; GO:0005829; GO:0030139; GO:0005783; GO:0010008; GO:0031232; GO:0042157; GO:0042953; GO:0043202; GO:0005765; GO:0042803; GO:0004872; GO:0006898; GO:0001894; GO:0005215; GO:0042359 Golgi apparatus; apical plasma membrane; brush border membrane; calcium ion binding; cholesterol metabolic process; coated pit; cobalamin binding; cobalamin metabolic process; cobalamin transport; cytosol; endocytic vesicle; endoplasmic reticulum; endosome membrane; extrinsic to external side of plasma membrane; lipoprotein metabolic process; lipoprotein transport; lysosomal lumen; lysosomal membrane; protein homodimerization activity; receptor activity; receptor-mediated endocytosis; tissue homeostasis; transporter activity; vitamin D metabolic process IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR009030; Cubilin (460 kDa receptor) (Intestinal intrinsic factor receptor) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) CUBN IFCR Homo sapiens (Human) TR28592_c0_g1_i2 Q20681 BAT38_CAEEL 1.00E-09 IPR000210; IPR011333; IPR013069; IPR002083; IPR008974; BTB and MATH domain-containing protein 38 bath-38 F52H3.3 Caenorhabditis elegans TR28593_c0_g2_i1 P10735 RT12_DROME 9.00E-46 GO:0008049; GO:0007638; GO:0005763; GO:0001666; GO:0007605; GO:0003735; GO:0006412 male courtship behavior; mechanosensory behavior; mitochondrial small ribosomal subunit; response to hypoxia; sensory perception of sound; structural constituent of ribosome; translation IPR012340; IPR006032; IPR005679; "40S ribosomal protein S12, mitochondrial (MRP-S12) (S12mt) (MT-RPS12) (Protein technical knockout locus)" tko CG7925 Drosophila melanogaster (Fruit fly) TR28594_c0_g1_i1 A4IF62 RPC1_BOVIN 0 GO:0003677; GO:0005666; GO:0003899; GO:0051607; GO:0045087; GO:0032728; GO:0032549; GO:0006383; GO:0008270 DNA binding; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase activity; defense response to virus; innate immune response; positive regulation of interferon-beta production; ribonucleoside binding; transcription from RNA polymerase III promoter; zinc ion binding IPR000722; IPR015700; IPR006592; IPR007080; IPR007066; IPR007083; IPR007081; DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III subunit A) POLR3A Bos taurus (Bovine) TR28594_c0_g3_i1 Q5ZL98 RPC1_CHICK 0 GO:0003677; GO:0003899; GO:0005634; GO:0032549; GO:0006351; GO:0008270 "DNA binding; DNA-directed RNA polymerase activity; nucleus; ribonucleoside binding; transcription, DNA-dependent; zinc ion binding" IPR000722; IPR015700; IPR006592; IPR007080; IPR007066; IPR007083; IPR007081; DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III subunit A) POLR3A RCJMB04_7b9 Gallus gallus (Chicken) TR28596_c1_g1_i1 Q09299 YQOA_CAEEL 9.00E-47 GO:0003723; GO:0000166 RNA binding; nucleotide binding IPR001810; IPR012677; IPR000504; Putative RNA-binding protein EEED8.10 EEED8.10 Caenorhabditis elegans TR28596_c1_g1_i2 Q5BJ29 FBXL7_MOUSE 1.00E-19 GO:0000086; GO:0019005; GO:0031146; GO:0051301; GO:0008283; GO:0005813; GO:0005737; GO:0007067; GO:0016567 G2/M transition of mitotic cell cycle; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; cell proliferation; centrosome; cytoplasm; mitosis; protein ubiquitination IPR001810; IPR006553; Protein modification; protein ubiquitination. F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) Fbxl7 Kiaa0840 Mus musculus (Mouse) TR28598_c0_g2_i1 Q9ES30 C1QT3_MOUSE 2.00E-12 GO:0005581; GO:0005615; GO:0042593; GO:0042802; GO:0045721; GO:0070374; GO:0070165; GO:0050715; GO:0051897; GO:0051259 collagen; extracellular space; glucose homeostasis; identical protein binding; negative regulation of gluconeogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of adiponectin secretion; positive regulation of cytokine secretion; positive regulation of protein kinase B signaling cascade; protein oligomerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1qtnf3 Cors26 Ctrp3 Mus musculus (Mouse) TR28602_c0_g1_i1 P54985 PPIA_BLAGE 3.00E-82 GO:0005737; GO:0042277; GO:0003755; GO:0006457; GO:0000413 cytoplasm; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Cyclophilin) (Cyclosporin A-binding protein) (Rotamase) CYPA Blattella germanica (German cockroach) (Blatta germanica) TR28605_c1_g1_i1 Q41253 RAC13_GOSHI 1.00E-32 GO:0005525; GO:0005737; GO:0016020; GO:0007264 GTP binding; cytoplasm; membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Rac-like GTP-binding protein RAC13 RAC13 Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) TR28605_c1_g1_i2 Q03206 RAC1_CAEEL 5.00E-38 GO:0005525; GO:0003924; GO:0006915; GO:0048846; GO:0031103; GO:0010171; GO:0009986; GO:0031410; GO:0005829; GO:0033563; GO:0043652; GO:0016021; GO:0009898; GO:0008045; GO:0002119; GO:0001764; GO:0030334; GO:0050764; GO:0007264 GTP binding; GTPase activity; apoptotic process; axon extension involved in axon guidance; axon regeneration; body morphogenesis; cell surface; cytoplasmic vesicle; cytosol; dorsal/ventral axon guidance; engulfment of apoptotic cell; integral to membrane; internal side of plasma membrane; motor neuron axon guidance; nematode larval development; neuron migration; regulation of cell migration; regulation of phagocytosis; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Ras-related protein ced-10 (CErac1) (Cell death protein 10) (Cell-corpse engulfment protein ced-10) (Ras-related protein rac-1) ced-10 rac-1 C09G12.8 Caenorhabditis elegans TR28605_c2_g1_i1 P34147 RACA_DICDI 1.00E-49 GO:0005525; GO:0005622; GO:0007264 GTP binding; intracellular; small GTPase mediated signal transduction IPR000210; IPR011333; IPR013069; IPR027417; IPR005225; IPR001806; IPR003578; Rho-related protein racA racA DDB_G0286555 Dictyostelium discoideum (Slime mold) TR28605_c2_g1_i4 Q9CTN4 RHBT3_MOUSE 1.00E-20 GO:0005524; GO:0016887; GO:0005525; GO:0005794; GO:0042147; GO:0007264 "ATP binding; ATPase activity; GTP binding; Golgi apparatus; retrograde transport, endosome to Golgi; small GTPase mediated signal transduction" IPR000210; IPR011333; IPR013069; IPR027417; IPR001806; Rho-related BTB domain-containing protein 3 (EC 3.6.1.-) Rhobtb3 Kiaa0878 Mus musculus (Mouse) TR28606_c0_g2_i1 Q567I9 CB5D1_DANRE 3.00E-86 GO:0020037; GO:0046872 heme binding; metal ion binding IPR001199; Cytochrome b5 domain-containing protein 1 cyb5d1 zgc:112008 Danio rerio (Zebrafish) (Brachydanio rerio) TR28606_c0_g2_i2 Q567I9 CB5D1_DANRE 9.00E-64 GO:0020037; GO:0046872 heme binding; metal ion binding IPR001199; Cytochrome b5 domain-containing protein 1 cyb5d1 zgc:112008 Danio rerio (Zebrafish) (Brachydanio rerio) TR28607_c1_g1_i1 Q00780 CO8A1_MOUSE 4.00E-07 GO:0001525; GO:0005604; GO:0048593; GO:0007155; GO:0005581; GO:0050673; GO:0010811 angiogenesis; basement membrane; camera-type eye morphogenesis; cell adhesion; collagen; epithelial cell proliferation; positive regulation of cell-substrate adhesion IPR001073; IPR008160; IPR008983; Collagen alpha-1(VIII) chain [Cleaved into: Vastatin] Col8a1 Mus musculus (Mouse) TR28608_c0_g1_i3 Q2NKT1 PROF4_BOVIN 8.00E-33 GO:0030036; GO:0005737; GO:0005856; GO:0008289 actin cytoskeleton organization; cytoplasm; cytoskeleton; lipid binding IPR005455; Profilin-4 PFN4 Bos taurus (Bovine) TR28610_c0_g1_i2 Q9NL83 ORCKA_PROCL 2.00E-16 GO:0005576; GO:0005184; GO:0007218 extracellular region; neuropeptide hormone activity; neuropeptide signaling pathway Orcokinin peptides type A [Cleaved into: Orcomyotropin-like peptide; Orcokinin; Orcokinin-like peptide 1; Orcokinin-like peptide 2; Orcokinin-like peptide 3; Orcokinin-like peptide 4] Procambarus clarkii (Red swamp crayfish) TR28611_c5_g1_i1 P08548 LIN1_NYCCO 5.00E-12 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR28612_c0_g1_i1 Q9H095 IQCG_HUMAN 3.00E-44 IPR000048; IQ domain-containing protein G IQCG Homo sapiens (Human) TR28616_c0_g1_i2 Q80Z71 TENN_MOUSE 7.00E-11 GO:0007409; GO:0016049; GO:0016477; GO:0009986; GO:0007160; GO:0042802; GO:0005178; GO:0005578 axonogenesis; cell growth; cell migration; cell surface; cell-matrix adhesion; identical protein binding; integrin binding; proteinaceous extracellular matrix IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR020837; IPR003961; IPR013783; Tenascin-N (TN-N) Tnn Mus musculus (Mouse) TR28619_c1_g2_i1 Q8K4P8 HECW1_MOUSE 7.00E-50 GO:0005737; GO:0005634; GO:0042787; GO:0004842 cytoplasm; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000008; IPR000569; IPR001202; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase HECW1 (EC 6.3.2.-) (HECT, C2 and WW domain-containing protein 1) (NEDD4-like E3 ubiquitin-protein ligase 1) (mNEDL1)" Hecw1 Kiaa0322 Nedl1 Mus musculus (Mouse) TR28619_c3_g1_i1 Q6I6G8 HECW2_MOUSE 3.00E-21 GO:0005737; GO:0005634; GO:0042787; GO:0004842 cytoplasm; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000008; IPR000569; IPR001202; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase HECW2 (EC 6.3.2.-) (HECT, C2 and WW domain-containing protein 2) (NEDD4-like E3 ubiquitin-protein ligase 2)" Hecw2 Kiaa1301 Nedl2 Mus musculus (Mouse) TR28624_c0_g3_i1 A4FV97 RL1D1_BOVIN 6.00E-35 GO:0003723; GO:0005730; GO:0032880 RNA binding; nucleolus; regulation of protein localization IPR023674; IPR028364; IPR016094; IPR016095; Ribosomal L1 domain-containing protein 1 RSL1D1 Bos taurus (Bovine) TR28628_c0_g1_i1 Q80YG3 KLDC1_MOUSE 4.00E-36 GO:0005737 cytoplasm IPR011043; IPR015915; Kelch domain-containing protein 1 Klhdc1 Mus musculus (Mouse) TR28630_c4_g2_i1 Q17QR6 MOT13_BOVIN 1.00E-35 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 13 (MCT 13) (Solute carrier family 16 member 13) SLC16A13 MCT13 Bos taurus (Bovine) TR28630_c4_g2_i2 Q8CE94 MOT13_MOUSE 1.00E-36 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 13 (MCT 13) (Solute carrier family 16 member 13) Slc16a13 Mct13 Mus musculus (Mouse) TR28635_c0_g1_i1 A1CIF6 S2538_ASPCL 2.00E-14 GO:0016021; GO:0005743; GO:0006810 integral to membrane; mitochondrial inner membrane; transport IPR018108; IPR023395; Solute carrier family 25 member 38 homolog ACLA_051330 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) TR28635_c0_g1_i3 Q4V9P0 SAMC_DANRE 2.00E-97 GO:0000095; GO:0016021; GO:0005743 S-adenosyl-L-methionine transmembrane transporter activity; integral to membrane; mitochondrial inner membrane IPR018108; IPR023395; S-adenosylmethionine mitochondrial carrier protein (Mitochondrial S-adenosylmethionine transporter) (Solute carrier family 25 member 26) slc25a26 samc zgc:110080 Danio rerio (Zebrafish) (Brachydanio rerio) TR28636_c1_g2_i1 Q3MHX6 OS9_BOVIN 9.00E-65 GO:0030433; GO:0005788; GO:0001948; GO:0006621; GO:0042787; GO:0034976 ER-associated protein catabolic process; endoplasmic reticulum lumen; glycoprotein binding; protein retention in ER lumen; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; response to endoplasmic reticulum stress IPR009011; IPR012913; Protein OS-9 OS9 Bos taurus (Bovine) TR28642_c0_g3_i1 Q5SNQ7 SRAC1_DANRE 8.00E-97 GO:0006505; GO:0005783; GO:0016788; GO:0016021; GO:0006886; GO:0005739; GO:0008654 "GPI anchor metabolic process; endoplasmic reticulum; hydrolase activity, acting on ester bonds; integral to membrane; intracellular protein transport; mitochondrion; phospholipid biosynthetic process" IPR011989; IPR016024; IPR012908; Protein SERAC1 (Serine active site-containing protein 1) serac1 Danio rerio (Zebrafish) (Brachydanio rerio) TR28643_c3_g1_i1 Q5XI68 NC2B_RAT 3.00E-56 GO:0005634; GO:0006355; GO:0043565; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription, DNA-dependent" IPR003958; IPR009072; IPR003957; Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein) Dr1 Rattus norvegicus (Rat) TR28644_c1_g1_i1 Q4V887 S39A6_RAT 1.00E-64 GO:0006882; GO:0005887; GO:0031258; GO:0071578; GO:0071577; GO:0005385 cellular zinc ion homeostasis; integral to plasma membrane; lamellipodium membrane; zinc ion transmembrane import; zinc ion transmembrane transport; zinc ion transmembrane transporter activity IPR003689; Zinc transporter ZIP6 (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6) Slc39a6 Zip6 Rattus norvegicus (Rat) TR28644_c1_g1_i2 Q9VSL7 FOI_DROME 4.00E-46 GO:0035147; GO:0009986; GO:0007417; GO:0035262; GO:0007506; GO:0005887; GO:0022008; GO:0007280; GO:0005385 "branch fusion, open tracheal system; cell surface; central nervous system development; gonad morphogenesis; gonadal mesoderm development; integral to plasma membrane; neurogenesis; pole cell migration; zinc ion transmembrane transporter activity" IPR003689; Zinc transporter foi (Protein fear-of-intimacy) (Protein kastchen) foi CG6817 Drosophila melanogaster (Fruit fly) TR28646_c0_g1_i1 A8WHR0 DCA17_DANRE 7.00E-74 GO:0080008; GO:0016021; GO:0005730; GO:0016567 Cul4-RING ubiquitin ligase complex; integral to membrane; nucleolus; protein ubiquitination Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 17 dcaf17 si:ch211-245g15.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR28647_c3_g1_i2 Q9UHJ6 SHPK_HUMAN 2.00E-59 GO:0005524; GO:0035963; GO:0071353; GO:0071222; GO:0005737; GO:0009052; GO:0050727; GO:0043030; GO:0050277 "ATP binding; cellular response to interleukin-13; cellular response to interleukin-4; cellular response to lipopolysaccharide; cytoplasm; pentose-phosphate shunt, non-oxidative branch; regulation of inflammatory response; regulation of macrophage activation; sedoheptulokinase activity" IPR018484; Sedoheptulokinase (SHK) (EC 2.7.1.14) (Carbohydrate kinase-like protein) SHPK CARKL Homo sapiens (Human) TR28648_c1_g1_i1 P21783 NOTCH_XENLA 1.00E-09 GO:0007219; GO:0005509; GO:0030154; GO:0016021; GO:0000122; GO:0007399; GO:0005654; GO:0004872; GO:0050793 Notch signaling pathway; calcium ion binding; cell differentiation; integral to membrane; negative regulation of transcription from RNA polymerase II promoter; nervous system development; nucleoplasm; receptor activity; regulation of developmental process IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022362; IPR000800; IPR010660; IPR011656; Neurogenic locus notch protein homolog (xOTCH) notch1 xotch Xenopus laevis (African clawed frog) TR28649_c2_g1_i1 P06868 PLMN_BOVIN 3.00E-68 GO:0007596; GO:0005576; GO:0042730; GO:0006508; GO:0004252; GO:0048771 blood coagulation; extracellular region; fibrinolysis; proteolysis; serine-type endopeptidase activity; tissue remodeling IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Bos taurus (Bovine) TR28649_c2_g1_i2 P26928 HGFL_MOUSE 2.00E-49 GO:0007566; GO:0005576; GO:0006508; GO:0004252 embryo implantation; extracellular region; proteolysis; serine-type endopeptidase activity IPR024174; IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR001254; IPR001314; IPR009003; Hepatocyte growth factor-like protein (Macrophage stimulatory protein) (MSP) [Cleaved into: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain] Mst1 Hgfl Mus musculus (Mouse) TR28649_c2_g1_i3 Q61EX6 NAS36_CAEBR 2.00E-18 GO:0005576; GO:0004222; GO:0007275; GO:0006508; GO:0008270 extracellular region; metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR000859; IPR024079; IPR001506; IPR017050; IPR006026; IPR000884; Zinc metalloproteinase nas-36 (EC 3.4.24.21) (Nematode astacin 36) nas-36 CBG11886 Caenorhabditis briggsae TR28650_c2_g1_i1 P0C0T2 ANKS6_RAT 1.00E-88 GO:0005737; GO:0042803 cytoplasm; protein homodimerization activity IPR002110; IPR020683; IPR001660; IPR013761; IPR021129; Ankyrin repeat and SAM domain-containing protein 6 (Polycystic kidney disease protein 1) (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6) Anks6 Pkdr1 Samd6 Rattus norvegicus (Rat) TR28650_c4_g1_i1 Q5U4T7 BIC1B_XENLA 1.00E-07 GO:0003723; GO:0007275 RNA binding; multicellular organismal development IPR004087; IPR004088; IPR001660; IPR013761; IPR021129; Protein bicaudal C homolog 1-B (Bic-C-B) bicc1-b Xenopus laevis (African clawed frog) TR28652_c1_g1_i1 P10620 MGST1_HUMAN 8.00E-43 GO:0033327; GO:0045177; GO:0071449; GO:0005789; GO:0043295; GO:1901687; GO:0006749; GO:0004602; GO:0004364; GO:0016021; GO:0005743; GO:0005741; GO:0005739; GO:0005634; GO:0005778; GO:0070207; GO:0042493; GO:0032496; GO:0010243; GO:0044281; GO:0006805 Q8WX92 Leydig cell differentiation; apical part of cell; cellular response to lipid hydroperoxide; endoplasmic reticulum membrane; glutathione binding; glutathione derivative biosynthetic process; glutathione metabolic process; glutathione peroxidase activity; glutathione transferase activity; integral to membrane; mitochondrial inner membrane; mitochondrial outer membrane; mitochondrion; nucleus; peroxisomal membrane; protein homotrimerization; response to drug; response to lipopolysaccharide; response to organonitrogen compound; small molecule metabolic process; xenobiotic metabolic process IPR023352; IPR001129; Microsomal glutathione S-transferase 1 (Microsomal GST-1) (EC 2.5.1.18) (Microsomal GST-I) MGST1 GST12 MGST Homo sapiens (Human) TR28652_c1_g1_i3 A0SYQ0 PTGES_CANFA 6.00E-18 GO:0005737; GO:0043295; GO:0016021; GO:0008285; GO:0005641; GO:0001516; GO:0050220 cytoplasm; glutathione binding; integral to membrane; negative regulation of cell proliferation; nuclear envelope lumen; prostaglandin biosynthetic process; prostaglandin-E synthase activity IPR023352; IPR001129; Prostaglandin E synthase (EC 5.3.99.3) (Microsomal prostaglandin E synthase 1) (MPGES-1) PTGES PGES Canis familiaris (Dog) (Canis lupus familiaris) TR28653_c1_g1_i1 Q86V15 CASZ1_HUMAN 2.00E-41 GO:0003677; GO:0005737; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cytoplasm; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) CASZ1 CST SRG ZNF693 Homo sapiens (Human) TR28658_c0_g1_i1 Q9D411 TSSK4_MOUSE 5.00E-99 GO:0005524; GO:0001669; GO:0030154; GO:0000287; GO:0031514; GO:0007275; GO:0032793; GO:0004674; GO:0007283 ATP binding; acrosomal vesicle; cell differentiation; magnesium ion binding; motile cilium; multicellular organismal development; positive regulation of CREB transcription factor activity; protein serine/threonine kinase activity; spermatogenesis IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Testis-specific serine/threonine-protein kinase 4 (TSK-4) (TSSK-4) (Testis-specific kinase 4) (EC 2.7.11.1) Tssk4 Mus musculus (Mouse) TR28662_c0_g2_i1 Q5R9F5 S38A7_PONAB 4.00E-65 GO:0015186; GO:0030424; GO:0016021; GO:0043025; GO:0006814 L-glutamine transmembrane transporter activity; axon; integral to membrane; neuronal cell body; sodium ion transport IPR013057; Putative sodium-coupled neutral amino acid transporter 7 (Solute carrier family 38 member 7) SLC38A7 SNAT7 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR28662_c0_g3_i1 P38176 AVT5_YEAST 5.00E-17 GO:0006865; GO:0016021; GO:0005215; GO:0005774 amino acid transport; integral to membrane; transporter activity; vacuolar membrane IPR013057; Vacuolar amino acid transporter 5 AVT5 YBL089W YBL0703 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR28669_c0_g1_i1 P06144 H1_LYTPI 5.00E-19 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR005818; IPR005819; IPR011991; Late histone H1 Lytechinus pictus (Painted sea urchin) TR28671_c1_g1_i1 O43301 HS12A_HUMAN 6.00E-33 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR28673_c0_g1_i1 Q12447 PAA1_YEAST 5.00E-18 GO:0004059; GO:0006325; GO:0005737; GO:0004145 P39966; P34221; P38089 aralkylamine N-acetyltransferase activity; chromatin organization; cytoplasm; diamine N-acetyltransferase activity IPR016181; IPR000182; Polyamine N-acetyltransferase 1 (EC 2.3.1.-) (Arylalkylamine N-acetyltransferase homolog) (scAANAT) PAA1 YDR071C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR28673_c0_g1_i2 Q64666 SNAT_RAT 4.00E-15 GO:0071889; GO:0006474; GO:0004059; GO:0004060; GO:0071320; GO:0007623; GO:0043153; GO:0030187; GO:0048471; GO:0051592; GO:0046688; GO:0051412; GO:0034097; GO:0032868; GO:0034695; GO:0010043 14-3-3 protein binding; N-terminal protein amino acid acetylation; aralkylamine N-acetyltransferase activity; arylamine N-acetyltransferase activity; cellular response to cAMP; circadian rhythm; entrainment of circadian clock by photoperiod; melatonin biosynthetic process; perinuclear region of cytoplasm; response to calcium ion; response to copper ion; response to corticosterone stimulus; response to cytokine stimulus; response to insulin stimulus; response to prostaglandin E stimulus; response to zinc ion IPR016181; IPR000182; Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2. Serotonin N-acetyltransferase (Serotonin acetylase) (EC 2.3.1.87) (Aralkylamine N-acetyltransferase) (AA-NAT) Aanat Snat Rattus norvegicus (Rat) TR28674_c0_g1_i1 Q9NBX4 RTXE_DROME 3.00E-31 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR28675_c2_g1_i1 Q96JI7 SPTCS_HUMAN 5.00E-88 GO:0008219; GO:0031410; GO:0005829; GO:0016021; GO:0005765; GO:0005730; GO:0005886 cell death; cytoplasmic vesicle; cytosol; integral to membrane; lysosomal membrane; nucleolus; plasma membrane IPR028103; IPR028107; Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) SPG11 KIAA1840 Homo sapiens (Human) TR28676_c1_g1_i1 Q71RQ7 STBA1_TRIST 2.00E-08 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Snaclec stejaggregin-B subunit alpha Trimeresurus stejnegeri (Chinese green tree viper) (Viridovipera stejnegeri) TR28676_c1_g2_i2 P86854 PLCL_MYTGA 2.00E-20 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR28678_c1_g1_i1 Q502K1 EXOG_DANRE 1.00E-118 GO:0004519; GO:0046872; GO:0005743; GO:0003676; GO:0090305 endonuclease activity; metal ion binding; mitochondrial inner membrane; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis IPR001604; IPR020821; "Nuclease EXOG, mitochondrial (EC 3.1.30.-) (Endonuclease G-like 1) (Endo G-like 1)" exog endogl1 Danio rerio (Zebrafish) (Brachydanio rerio) TR28681_c0_g1_i1 Q9UKK9 NUDT5_HUMAN 3.00E-59 GO:0047631; GO:0019144; GO:0019303; GO:0005829; GO:0000287; GO:0034656; GO:0017110; GO:0009117; GO:0009191; GO:0030515 ADP-ribose diphosphatase activity; ADP-sugar diphosphatase activity; D-ribose catabolic process; cytosol; magnesium ion binding; nucleobase-containing small molecule catabolic process; nucleoside-diphosphatase activity; nucleotide metabolic process; ribonucleoside diphosphate catabolic process; snoRNA binding IPR020476; IPR020084; IPR000086; IPR015797; ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (YSA1H) NUDT5 HSPC115 Homo sapiens (Human) TR28681_c0_g1_i2 P45799 NUDE_ECOLI 2.00E-06 GO:0019144; GO:0046872 ADP-sugar diphosphatase activity; metal ion binding IPR020084; IPR000086; IPR015797; ADP compounds hydrolase NudE (EC 3.6.1.-) nudE yrfE b3397 JW3360 Escherichia coli (strain K12) TR28682_c2_g1_i1 O35048 3BHS7_RAT 5.00E-07 GO:0003854; GO:0008206; GO:0047016; GO:0005789; GO:0016021; GO:0043231; GO:0001558; GO:0006694 "3-beta-hydroxy-delta5-steroid dehydrogenase activity; bile acid metabolic process; cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity; endoplasmic reticulum membrane; integral to membrane; intracellular membrane-bounded organelle; regulation of cell growth; steroid biosynthetic process" IPR002225; IPR016040; Lipid metabolism; steroid biosynthesis. "3 beta-hydroxysteroid dehydrogenase type 7 (3 beta-hydroxysteroid dehydrogenase type VII) (3-beta-HSD VII) (3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase) (C(27) 3-beta-HSD) (EC 1.1.1.-) (Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase) (EC 1.1.1.181) (Confluent 3Y1 cell-associated 2)" Hsd3b7 Cca2 Rattus norvegicus (Rat) TR28682_c3_g1_i1 P26150 3BHS3_MOUSE 2.00E-22 GO:0003854; GO:0005789; GO:0016021; GO:0005743; GO:0006694; GO:0004769 3-beta-hydroxy-delta5-steroid dehydrogenase activity; endoplasmic reticulum membrane; integral to membrane; mitochondrial inner membrane; steroid biosynthetic process; steroid delta-isomerase activity IPR002225; IPR016040; Lipid metabolism; steroid biosynthesis. 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type III) (3-beta-HSD III) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)] Hsd3b3 Mus musculus (Mouse) TR28685_c0_g2_i2 A6H751 FOLC_BOVIN 1.00E-141 GO:0005524; GO:0005743; GO:0005759; GO:0006730; GO:0004326 ATP binding; mitochondrial inner membrane; mitochondrial matrix; one-carbon metabolic process; tetrahydrofolylpolyglutamate synthase activity IPR001645; IPR018109; IPR023600; IPR004101; IPR013221; Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis. "Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolate synthase) (Tetrahydrofolylpolyglutamate synthase)" FPGS Bos taurus (Bovine) TR28685_c0_g2_i5 Q8W035 FPGS3_ARATH 2.00E-92 GO:0005524; GO:0005737; GO:0006730; GO:0004326 ATP binding; cytoplasm; one-carbon metabolic process; tetrahydrofolylpolyglutamate synthase activity IPR001645; IPR018109; IPR023600; IPR004101; IPR013221; Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis. Folylpolyglutamate synthase (EC 6.3.2.17) (DHFS-FPGS homolog D) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase) FPGS3 ATDFD DFD FPGS4 FPGSD At3g55630 F1I16_40 Arabidopsis thaliana (Mouse-ear cress) TR28688_c3_g1_i1 Q9DAG5 CB061_MOUSE 3.00E-28 IPR010736; Uncharacterized protein C2orf61 homolog Mus musculus (Mouse) TR28688_c3_g1_i2 Q8N801 CB061_HUMAN 2.00E-13 IPR010736; Uncharacterized protein C2orf61 C2orf61 Homo sapiens (Human) TR28689_c3_g1_i1 Q8BXX2 ZBT49_MOUSE 2.00E-17 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) Zbtb49 Zfp509 Znf509 Mus musculus (Mouse) TR28690_c0_g2_i1 Q12972 PP1R8_HUMAN 6.00E-87 GO:0003677; GO:0003723; GO:0006401; GO:0008380; GO:0008283; GO:0005737; GO:0004519; GO:0006397; GO:0016607; GO:0008599; GO:0004865; GO:0006355; GO:0008995; GO:0005681; GO:0006351 P62136 "DNA binding; RNA binding; RNA catabolic process; RNA splicing; cell proliferation; cytoplasm; endonuclease activity; mRNA processing; nuclear speck; protein phosphatase type 1 regulator activity; protein serine/threonine phosphatase inhibitor activity; regulation of transcription, DNA-dependent; ribonuclease E activity; spliceosomal complex; transcription, DNA-dependent" IPR000253; IPR008984; Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)] PPP1R8 ARD1 NIPP1 Homo sapiens (Human) TR28691_c2_g1_i1 P02552 TBA1_CHICK 8.00E-138 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-1 chain (Fragment) Gallus gallus (Chicken) TR28691_c2_g1_i2 P18699 TBB_LYMST 1.00E-14 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; Tubulin beta chain (Beta-tubulin) (Fragment) Lymnaea stagnalis (Great pond snail) TR28691_c2_g1_i4 P02553 TBA_LYTPI 6.00E-104 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; Tubulin alpha chain (Fragment) Lytechinus pictus (Painted sea urchin) TR28691_c2_g2_i2 Q9H853 TBA4B_HUMAN 4.00E-97 GO:0005525; GO:0005737; GO:0005874; GO:0007017; GO:0005200 GTP binding; cytoplasm; microtubule; microtubule-based process; structural constituent of cytoskeleton IPR002452; IPR000217; IPR003008; Putative tubulin-like protein alpha-4B (Alpha-tubulin 4B) TUBA4B TUBA4 Homo sapiens (Human) TR28691_c2_g2_i3 P06603 TBA1_DROME 2.00E-153 GO:0005525; GO:0003924; GO:0019730; GO:0000235; GO:0005813; GO:0007094; GO:0007052; GO:0051258; GO:0005200 GTP binding; GTPase activity; antimicrobial humoral response; astral microtubule; centrosome; mitotic spindle assembly checkpoint; mitotic spindle organization; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-1 chain alphaTub84B tubA84B CG1913 Drosophila melanogaster (Fruit fly) TR28691_c2_g2_i4 Q9SEA4 TBGN_GUITH 3.00E-10 GO:0005525; GO:0003924; GO:0031122; GO:0000930; GO:0005874; GO:0007020; GO:0051258 GTP binding; GTPase activity; cytoplasmic microtubule organization; gamma-tubulin complex; microtubule; microtubule nucleation; protein polymerization IPR002454; IPR008280; IPR000217; IPR003008; "Tubulin gamma chain, nucleomorph (Nucleomorph gamma-tubulin)" tubG gtubNM Guillardia theta (Cryptomonas phi) TR28691_c3_g1_i1 P33626 TBA4_MAIZE 3.00E-25 GO:0005525; GO:0005737; GO:0005874; GO:0007017 GTP binding; cytoplasm; microtubule; microtubule-based process IPR000217; IPR003008; Tubulin alpha-4 chain (Alpha-4-tubulin) (Fragments) TUBA4 TUA4 Zea mays (Maize) TR28694_c0_g1_i1 Q0PMG2 MDGA1_MOUSE 8.00E-08 GO:0046658; GO:0021799; GO:0001764 anchored to plasma membrane; cerebral cortex radially oriented cell migration; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 Mdga1 Mus musculus (Mouse) TR28694_c4_g2_i1 Q5VYJ5 CJ112_HUMAN 6.00E-12 GO:0016021 integral to membrane IPR008985; IPR023415; IPR002172; IPR000998; MAM and LDL-receptor class A domain-containing protein C10orf112 C10orf112 Homo sapiens (Human) TR28694_c4_g2_i2 Q8NFP4 MDGA1_HUMAN 5.00E-16 GO:0046658; GO:0007420; GO:0001764; GO:0021527 anchored to plasma membrane; brain development; neuron migration; spinal cord association neuron differentiation IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3) MDGA1 MAMDC3 Homo sapiens (Human) TR28697_c0_g1_i2 P16924 P4HA1_CHICK 1.00E-28 GO:0031418; GO:0005788; GO:0005506; GO:0016702; GO:0004656 "L-ascorbic acid binding; endoplasmic reticulum lumen; iron ion binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; procollagen-proline 4-dioxygenase activity" IPR005123; IPR006620; IPR013547; IPR013026; IPR011990; IPR019734; "Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)" P4HA1 P4HA Gallus gallus (Chicken) TR28698_c2_g1_i1 Q3UR85 MRF_MOUSE 6.00E-88 GO:0003677; GO:0032286; GO:0016021; GO:0005634; GO:0031643; GO:0045893; GO:0043565; GO:0003700; GO:0006351 "DNA binding; central nervous system myelin maintenance; integral to membrane; nucleus; positive regulation of myelination; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR026933; IPR026932; IPR025719; IPR024061; IPR008967; "Myelin regulatory factor (EC 3.4.-.-) (Myelin gene regulatory factor) [Cleaved into: Myelin regulatory factor, N-terminal; Myelin regulatory factor, C-terminal]" Myrf Gm1804 Gm98 Mrf Mus musculus (Mouse) TR28702_c0_g1_i1 P0CS42 LIS1_CRYNJ 1.00E-17 GO:0051301; GO:0006928; GO:0005737; GO:0000132; GO:0005874; GO:0005875; GO:0007067; GO:0000922; GO:0006810 cell division; cellular component movement; cytoplasm; establishment of mitotic spindle orientation; microtubule; microtubule associated complex; mitosis; spindle pole; transport IPR017252; IPR020472; IPR006594; IPR015943; IPR001680; IPR019775; IPR017986; Nuclear distribution protein PAC1 (Lissencephaly-1 homolog) (LIS-1) (nudF homolog) PAC1 LIS1 CND02590 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR28702_c0_g1_i2 Q803V5 LST8_DANRE 0 GO:0005737 cytoplasm IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; "Target of rapamycin complex subunit lst8 (TORC subunit lst8) (G protein beta subunit-like) (Gable) (Protein GbetaL) (MTOR associated protein, LST8 homolog)" mlst8 gbl lst8 zgc:55455 zgc:85668 Danio rerio (Zebrafish) (Brachydanio rerio) TR28703_c1_g1_i1 Q1JQE6 NCEH1_BOVIN 2.00E-58 GO:0004091; GO:0005783; GO:0016021; GO:0016042; GO:0042301; GO:0006470; GO:0017171; GO:0006805 carboxylesterase activity; endoplasmic reticulum; integral to membrane; lipid catabolic process; phosphate ion binding; protein dephosphorylation; serine hydrolase activity; xenobiotic metabolic process IPR013094; IPR017157; IPR002168; Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Arylacetamide deacetylase-like 1) NCEH1 AADACL1 Bos taurus (Bovine) TR28711_c2_g1_i1 P19477 FIBA_PARPA 3.00E-38 IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein A (FREP-A) Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) TR28711_c2_g1_i2 Q1RMR1 ANGL1_BOVIN 3.00E-32 GO:0005615; GO:0007169 extracellular space; transmembrane receptor protein tyrosine kinase signaling pathway IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-related protein 1 (Angiopoietin-like protein 1) ANGPTL1 Bos taurus (Bovine) TR28711_c2_g1_i3 Q29116 TENA_PIG 7.00E-48 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (P230) (Tenascin-C) (TN-C) TNC HXB Sus scrofa (Pig) TR28712_c2_g2_i1 Q8MY85 FGFR2_DUGJA 3.00E-25 GO:0005524; GO:0016021; GO:0018108; GO:0004714 ATP binding; integral to membrane; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity IPR007110; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 2 (DjFgfr2) (FGFR-2) (EC 2.7.10.1) (DjPTK1) FGFR2 Dugesia japonica (Planarian) TR28716_c0_g1_i1 Q8R2V3 ZN445_MOUSE 6.00E-15 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein 445 Znf445 Zfp445 Mus musculus (Mouse) TR28716_c1_g1_i1 Q10076 YANB_SCHPO 6.00E-10 GO:0000978; GO:0046872; GO:0000790; GO:0043619; GO:0006351 "RNA polymerase II core promoter proximal region sequence-specific DNA binding; metal ion binding; nuclear chromatin; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Hydrogen peroxide stress regulator 1 hsr1 SPAC3H1.11 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR28717_c1_g1_i1 Q38PU2 GRIK3_MACFA 8.00E-93 GO:0001640; GO:0030054; GO:0043197; GO:0005234; GO:0016021; GO:0004970; GO:0045211 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity; cell junction; dendritic spine; extracellular-glutamate-gated ion channel activity; integral to membrane; ionotropic glutamate receptor activity; postsynaptic membrane IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; "Glutamate receptor ionotropic, kainate 3 (GluK3) (Glutamate receptor 7) (GluR-7) (GluR7)" GRIK3 GLUR7 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR28717_c1_g4_i2 Q91755 GRIK2_XENLA 1.00E-24 GO:0030054; GO:0005234; GO:0016021; GO:0004970; GO:0035235; GO:0045211 cell junction; extracellular-glutamate-gated ion channel activity; integral to membrane; ionotropic glutamate receptor activity; ionotropic glutamate receptor signaling pathway; postsynaptic membrane IPR001320; IPR001508; "Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6) (Fragment)" grik2 glur6 Xenopus laevis (African clawed frog) TR28718_c0_g2_i1 A7RHB3 U732_NEMVE 7.00E-06 UPF0732 protein v1g81173 v1g81173 Nematostella vectensis (Starlet sea anemone) TR28720_c0_g1_i1 Q63ZL2 HOP2_XENLA 5.00E-67 GO:0006310; GO:0007126; GO:0005634 DNA recombination; meiosis; nucleus IPR010776; IPR011991; Homologous-pairing protein 2 homolog (PSMC3-interacting protein) (Proteasome 26S ATPase subunit 3-interacting protein) psmc3ip Xenopus laevis (African clawed frog) TR28720_c0_g1_i2 Q9FX64 HOP2_ARATH 4.00E-23 GO:0006310; GO:0051026; GO:0005634 DNA recombination; chiasma assembly; nucleus IPR010776; Homologous-pairing protein 2 homolog (Protein AHP2) (AtAHP2) (Protein ARABIDOPSIS HOMOLOG PAIRING 2) (Protein HOP2) (AtHOP2) HOP2 AHP2 At1g13330 T6J4.9 Arabidopsis thaliana (Mouse-ear cress) TR28723_c0_g1_i1 Q9Y4C4 MFHA1_HUMAN 4.00E-21 IPR001611; IPR003591; IPR027417; IPR020859; Malignant fibrous histiocytoma-amplified sequence 1 (Malignant fibrous histiocytoma-amplified sequence with leucine-rich tandem repeats 1) MFHAS1 MASL1 Homo sapiens (Human) TR28724_c0_g2_i1 O15973 OPSD1_MIZYE 4.00E-11 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR000856; IPR027430; "Rhodopsin, GQ-coupled (GQ-rhodopsin)" SCOP1 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) TR28725_c0_g1_i2 Q7SZE8 TP8L1_DANRE 6.00E-47 IPR008477; Tumor necrosis factor alpha-induced protein 8-like protein 1 (TNF alpha-induced protein 8-like protein 1) (TNFAIP8-like protein 1) tnfaip8l1 tnfaip8 si:dkey-49m19.6 zgc:55331 Danio rerio (Zebrafish) (Brachydanio rerio) TR28728_c0_g1_i1 Q39016 CDPKB_ARATH 1.00E-07 GO:0005524; GO:0005509; GO:0004683; GO:0005829; GO:0005634; GO:0005886; GO:0009789; GO:0046777; GO:1901979; GO:0080092 Q9ZSK4; Q9C944; Q27GK5; Q940C2; Q94BN0; Q9CA67; Q39083; O23338; O04482; O80800; O23680 ATP binding; calcium ion binding; calmodulin-dependent protein kinase activity; cytosol; nucleus; plasma membrane; positive regulation of abscisic acid mediated signaling pathway; protein autophosphorylation; regulation of inward rectifier potassium channel activity; regulation of pollen tube growth IPR011992; IPR018247; IPR002048; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium-dependent protein kinase 11 (EC 2.7.11.1) (Calcium-dependent protein kinase isoform CDPK2) (AtCDPK2) CPK11 CDPK2 At1g35670 F15O4.8 Arabidopsis thaliana (Mouse-ear cress) TR28730_c0_g2_i1 Q07553 GCY3E_DROME 3.00E-26 GO:0005524; GO:0005525; GO:0004383; GO:0005887; GO:0035556; GO:0004872; GO:0016772 "ATP binding; GTP binding; guanylate cyclase activity; integral to plasma membrane; intracellular signal transduction; receptor activity; transferase activity, transferring phosphorus-containing groups" IPR001054; IPR018297; IPR001828; IPR011009; IPR028082; IPR000719; IPR001245; Guanylate cyclase 32E (EC 4.6.1.2) Gyc32E GC CG33114 Drosophila melanogaster (Fruit fly) TR28730_c0_g2_i2 Q07553 GCY3E_DROME 4.00E-26 GO:0005524; GO:0005525; GO:0004383; GO:0005887; GO:0035556; GO:0004872; GO:0016772 "ATP binding; GTP binding; guanylate cyclase activity; integral to plasma membrane; intracellular signal transduction; receptor activity; transferase activity, transferring phosphorus-containing groups" IPR001054; IPR018297; IPR001828; IPR011009; IPR028082; IPR000719; IPR001245; Guanylate cyclase 32E (EC 4.6.1.2) Gyc32E GC CG33114 Drosophila melanogaster (Fruit fly) TR28733_c0_g1_i1 Q7Z5L0 VMO1_HUMAN 3.00E-35 GO:0005576; GO:0030704 extracellular region; vitelline membrane formation IPR005515; Vitelline membrane outer layer protein 1 homolog VMO1 UNQ6350/PRO21055 Homo sapiens (Human) TR28734_c1_g1_i1 Q504A5 TPMT_DANRE 2.00E-30 GO:0005737; GO:0008119 cytoplasm; thiopurine S-methyltransferase activity IPR025835; IPR008854; Probable thiopurine S-methyltransferase (Thiopurine methyltransferase) (EC 2.1.1.67) tpmt zgc:109981 Danio rerio (Zebrafish) (Brachydanio rerio) TR28734_c1_g1_i2 Q3BCR4 TPMT_CHLAE 9.00E-33 GO:0005737; GO:0008119 cytoplasm; thiopurine S-methyltransferase activity IPR025835; IPR008854; Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) TPMT Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) TR28734_c1_g1_i3 Q3BCR6 TPMT_HORSE 5.00E-33 GO:0005737; GO:0008119 cytoplasm; thiopurine S-methyltransferase activity IPR025835; IPR008854; Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) TPMT Equus caballus (Horse) TR28737_c0_g1_i2 P86733 KCP_HALAI 3.00E-26 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; BPTI/Kunitz domain-containing protein (Fragment) Haliotis asinina (Donkey's ear abalone) (Ass's ear abalone) TR28738_c3_g1_i1 Q9HC77 CENPJ_HUMAN 4.00E-88 GO:0000086; GO:0051301; GO:0005814; GO:0007099; GO:0005829; GO:0008275; GO:0005874; GO:0007020; GO:0046785; GO:0046599; GO:0015631 Q66GS9; Q96RK0; Q5VTD9; Q9NYY3; Q15468; O95271 G2/M transition of mitotic cell cycle; cell division; centriole; centriole replication; cytosol; gamma-tubulin small complex; microtubule; microtubule nucleation; microtubule polymerization; regulation of centriole replication; tubulin binding IPR009852; IPR026581; Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1) CENPJ CPAP LAP LIP1 Homo sapiens (Human) TR28739_c0_g1_i1 O42260 GEMI2_XENLA 2.00E-52 GO:0097504; GO:0005737; GO:0005681; GO:0000245; GO:0000387 Gemini of coiled bodies; cytoplasm; spliceosomal complex; spliceosomal complex assembly; spliceosomal snRNP assembly IPR007022; IPR017364; Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1) gemin2 sip1 Xenopus laevis (African clawed frog) TR28742_c0_g1_i1 P86179 CSL3_ONCKE 1.00E-13 GO:0030246 carbohydrate binding IPR000922; L-rhamnose-binding lectin CSL3 Oncorhynchus keta (Chum salmon) (Salmo keta) TR28744_c0_g1_i1 A1TLB1 KYNB_ACIAC 1.00E-07 GO:0043420; GO:0004061; GO:0004328; GO:0019441 anthranilate metabolic process; arylformamidase activity; formamidase activity; tryptophan catabolic process to kynurenine IPR007325; IPR017484; Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. Kynurenine formamidase (KFA) (KFase) (EC 3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF) kynB Aave_1157 Acidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli) TR28746_c2_g1_i1 Q63625 PHRF1_RAT 4.00E-25 GO:0006397; GO:0019904; GO:0006366; GO:0008270 mRNA processing; protein domain specific binding; transcription from RNA polymerase II promoter; zinc ion binding IPR019786; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; PHD and RING finger domain-containing protein 1 (CTD-binding SR-like protein rA9) Phrf1 Rattus norvegicus (Rat) TR28747_c0_g1_i2 P30176 YBIA_ECOLI 8.00E-08 GO:0006928 cellular component movement IPR012816; Swarming motility protein YbiA ybiA b0798 JW0783 Escherichia coli (strain K12) TR28747_c0_g1_i4 Q5UR67 YR617_MIMIV 2.00E-29 IPR012816; Uncharacterized protein R617 MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) TR28749_c0_g1_i1 P13277 CYSP1_HOMAM 7.00E-59 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Digestive cysteine proteinase 1 (EC 3.4.22.-) LCP1 Homarus americanus (American lobster) TR28749_c0_g1_i2 Q91ZF2 CAT7_MOUSE 3.00E-44 GO:0005794; GO:0051301; GO:0008234; GO:0005768; GO:0005576; GO:0005615; GO:0005764; GO:0007067; GO:0045930; GO:0005634; GO:0008233; GO:0048471; GO:0006508; GO:0060707 Golgi apparatus; cell division; cysteine-type peptidase activity; endosome; extracellular region; extracellular space; lysosome; mitosis; negative regulation of mitotic cell cycle; nucleus; peptidase activity; perinuclear region of cytoplasm; proteolysis; trophoblast giant cell differentiation IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin 7 (EC 3.4.22.-) (Cathepsin 1) Cts7 Cts1 Epcs24 Mus musculus (Mouse) TR28751_c2_g1_i1 Q04638 ITT1_YEAST 3.00E-16 GO:0006449; GO:0008270 P05453 regulation of translational termination; zinc ion binding IPR002867; IPR001841; Translation termination inhibitor protein ITT1 ITT1 YML068W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR28751_c2_g1_i2 P36113 YKZ7_YEAST 8.00E-08 GO:0036205; GO:0016574; GO:0003676; GO:0004842; GO:0008270 histone catabolic process; histone ubiquitination; nucleic acid binding; ubiquitin-protein ligase activity; zinc ion binding IPR018957; IPR002867; IPR001878; IPR001841; IPR013083; IPR017907; RING finger protein YKR017C YKR017C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR28751_c2_g2_i1 Q9US46 ITT1_SCHPO 2.00E-22 GO:0002184; GO:0005829; GO:0005634; GO:0006449; GO:0004842; GO:0008270 cytoplasmic translational termination; cytosol; nucleus; regulation of translational termination; ubiquitin-protein ligase activity; zinc ion binding IPR006575; IPR016135; IPR002867; IPR001841; IPR013083; E3 ubiquitin-protein ligase itt1 (EC 6.3.2.-) (RING finger protein itt1) itt1 SPAC1002.14 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR28751_c2_g2_i2 Q9UBS8 RNF14_HUMAN 4.00E-67 GO:0030521; GO:0005737; GO:0005634; GO:0045893; GO:0016567; GO:0060765; GO:0006357; GO:0032355; GO:0019787; GO:0003713; GO:0006351; GO:0008270 P10275 "androgen receptor signaling pathway; cytoplasm; nucleus; positive regulation of transcription, DNA-dependent; protein ubiquitination; regulation of androgen receptor signaling pathway; regulation of transcription from RNA polymerase II promoter; response to estradiol stimulus; small conjugating protein ligase activity; transcription coactivator activity; transcription, DNA-dependent; zinc ion binding" IPR006575; IPR016135; IPR002867; IPR001841; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF14 (EC 6.3.2.-) (Androgen receptor-associated protein 54) (HFB30) (RING finger protein 14) (Triad2 protein) RNF14 ARA54 HRIHFB2038 Homo sapiens (Human) TR28754_c1_g1_i1 Q99704 DOK1_HUMAN 2.00E-09 GO:0007265; GO:0005829; GO:0008286; GO:0007243; GO:0005634; GO:0048471; GO:0005543; GO:0005057 Q9JIY2; P04626; Q9Q2G4; Q9H3Y6 Ras protein signal transduction; cytosol; insulin receptor signaling pathway; intracellular protein kinase cascade; nucleus; perinuclear region of cytoplasm; phospholipid binding; receptor signaling protein activity IPR002404; IPR011993; IPR001849; Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) DOK1 Homo sapiens (Human) TR28755_c0_g1_i1 Q9Y2S2 CRYL1_HUMAN 2.00E-94 GO:0003857; GO:0050104; GO:0070403; GO:0005829; GO:0006631 3-hydroxyacyl-CoA dehydrogenase activity; L-gulonate 3-dehydrogenase activity; NAD+ binding; cytosol; fatty acid metabolic process IPR022694; IPR006180; IPR006176; IPR006108; IPR008927; IPR013328; IPR016040; Lambda-crystallin homolog (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) (Gul3DH) CRYL1 CRY Homo sapiens (Human) TR28758_c0_g1_i2 O75691 UTP20_HUMAN 3.00E-48 GO:0030686; GO:0005737; GO:0000480; GO:0000447; GO:0000472; GO:0008285; GO:0005730; GO:0005654; GO:0030688; GO:0032040 Q5T8A7 "90S preribosome; cytoplasm; endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); negative regulation of cell proliferation; nucleolus; nucleoplasm; preribosome, small subunit precursor; small-subunit processome" IPR011989; IPR016024; IPR011430; Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) UTP20 DRIM Homo sapiens (Human) TR28758_c0_g2_i1 P35194 UTP20_YEAST 3.00E-12 GO:0030686; GO:0005737; GO:0000480; GO:0000447; GO:0000472; GO:0005730; GO:0005654; GO:0030688; GO:0032040 "90S preribosome; cytoplasm; endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleolus; nucleoplasm; preribosome, small subunit precursor; small-subunit processome" IPR011989; IPR016024; IPR011430; U3 small nucleolar RNA-associated protein 20 (U3 snoRNA-associated protein 20) (U three protein 20) UTP20 YBL004W YBL0101 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR2876_c0_g1_i1 P32198 CPT1A_RAT 3.00E-24 GO:0004095; GO:0009437; GO:0071398; GO:0042755; GO:0006635; GO:0006006; GO:0042802; GO:0031307; GO:0001676; GO:0005743; GO:0032000; GO:0051260; GO:0050796; GO:0042493; GO:0014070; GO:0006810; GO:0006641 carnitine O-palmitoyltransferase activity; carnitine metabolic process; cellular response to fatty acid; eating behavior; fatty acid beta-oxidation; glucose metabolic process; identical protein binding; integral to mitochondrial outer membrane; long-chain fatty acid metabolic process; mitochondrial inner membrane; positive regulation of fatty acid beta-oxidation; protein homooligomerization; regulation of insulin secretion; response to drug; response to organic cyclic compound; transport; triglyceride metabolic process IPR000542; Lipid metabolism; fatty acid beta-oxidation. "Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A)" Cpt1a Cpt-1 Cpt1 Rattus norvegicus (Rat) TR28769_c0_g1_i1 O75643 U520_HUMAN 0 GO:0005524; GO:0004004; GO:0005682; GO:0071013; GO:0000354; GO:0003676; GO:0005654 Itself; O15541 ATP binding; ATP-dependent RNA helicase activity; U5 snRNP; catalytic step 2 spliceosome; cis assembly of pre-catalytic spliceosome; nucleic acid binding; nucleoplasm IPR003593; IPR011545; IPR014001; IPR001650; IPR014756; IPR027417; IPR004179; U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) SNRNP200 ASCC3L1 HELIC2 KIAA0788 Homo sapiens (Human) TR28769_c1_g1_i1 Q9V0A9 HELS_PYRAB 5.00E-19 GO:0005524; GO:0008026; GO:0003677; GO:0006281 ATP binding; ATP-dependent helicase activity; DNA binding; DNA repair IPR011545; IPR014001; IPR001650; IPR022965; IPR003583; IPR027417; IPR014014; Putative ski2-type helicase (EC 3.6.4.-) PYRAB08810 PAB0592 Pyrococcus abyssi (strain GE5 / Orsay) TR28770_c3_g1_i1 P55245 EGFR_MACMU 1.00E-14 GO:0005524; GO:0000139; GO:0016323; GO:0000902; GO:0008283; GO:0016337; GO:0071392; GO:0021795; GO:0003682; GO:0048546; GO:0001892; GO:0030139; GO:0005789; GO:0005768; GO:0010008; GO:0005006; GO:0001942; GO:0045121; GO:0060571; GO:0043066; GO:0042177; GO:0030235; GO:0031965; GO:0005634; GO:0048471; GO:0045739; GO:0045740; GO:0070374; GO:0043406; GO:0035413; GO:0030335; GO:0031659; GO:0050679; GO:0048146; GO:0045429; GO:0051897; GO:0001934; GO:0045944; GO:0046777; GO:0004713; GO:0050999; GO:0050730; GO:0070141; GO:0007435 ATP binding; Golgi membrane; basolateral plasma membrane; cell morphogenesis; cell proliferation; cell-cell adhesion; cellular response to estradiol stimulus; cerebral cortex cell migration; chromatin binding; digestive tract morphogenesis; embryonic placenta development; endocytic vesicle; endoplasmic reticulum membrane; endosome; endosome membrane; epidermal growth factor-activated receptor activity; hair follicle development; membrane raft; morphogenesis of an epithelial fold; negative regulation of apoptotic process; negative regulation of protein catabolic process; nitric-oxide synthase regulator activity; nuclear membrane; nucleus; perinuclear region of cytoplasm; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAP kinase activity; positive regulation of catenin import into nucleus; positive regulation of cell migration; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of nitric oxide biosynthetic process; positive regulation of protein kinase B signaling cascade; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein autophosphorylation; protein tyrosine kinase activity; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; response to UV-A; salivary gland morphogenesis IPR011009; IPR000719; IPR001245; Epidermal growth factor receptor (EC 2.7.10.1) (Fragment) EGFR Macaca mulatta (Rhesus macaque) TR28770_c4_g1_i1 P11681 ABL_CALVI 5.00E-13 GO:0005524; GO:0005737; GO:0004715; GO:0018108 ATP binding; cytoplasm; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR011009; IPR000719; IPR001245; IPR008266; Tyrosine-protein kinase ABL (EC 2.7.10.2) (Fragment) ABL Calliphora vicina (Blue blowfly) (Calliphora erythrocephala) TR28770_c4_g1_i2 Q2IBC0 MET_RHIFE 8.00E-58 GO:0005524; GO:0016021; GO:0007275; GO:0018108; GO:0004714; GO:0007169 ATP binding; integral to membrane; multicellular organismal development; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR013783; IPR014756; IPR002909; IPR011009; IPR016201; IPR002165; IPR000719; IPR017441; IPR001627; IPR001245; IPR008266; IPR020635; IPR016244; IPR015943; Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) MET Rhinolophus ferrumequinum (Greater horseshoe bat) TR28771_c0_g1_i2 B5XG19 WIBGB_SALSA 3.00E-20 GO:0005737; GO:0035145; GO:0000184; GO:0005730; GO:0005654; GO:0045727; GO:0043022 "cytoplasm; exon-exon junction complex; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleolus; nucleoplasm; positive regulation of translation; ribosome binding" IPR015362; Partner of Y14 and mago B (Protein wibg homolog B) wibgb pymb Salmo salar (Atlantic salmon) TR28771_c0_g1_i3 B5XDD3 WIBGA_SALSA 1.00E-19 GO:0005737; GO:0035145; GO:0000184; GO:0005730; GO:0005654; GO:0045727; GO:0043022 "cytoplasm; exon-exon junction complex; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleolus; nucleoplasm; positive regulation of translation; ribosome binding" IPR015362; Partner of Y14 and mago A (Protein wibg homolog A) wibga pyma Salmo salar (Atlantic salmon) TR28774_c0_g2_i1 Q924Z6 XPO6_MOUSE 1.00E-168 GO:0005737; GO:0005634; GO:0006611 cytoplasm; nucleus; protein export from nucleus IPR011989; IPR016024; IPR013598; IPR001494; Exportin-6 (Exp6) (Ran-binding protein 20) Xpo6 Ranbp20 Mus musculus (Mouse) TR28775_c0_g2_i1 Q9C1X4 YKW3_SCHPO 8.00E-08 GO:0004842; GO:0008270 ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Uncharacterized RING finger protein P32A8.03c SPAP32A8.03c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR28775_c7_g1_i1 Q6NY19 KANK3_HUMAN 3.00E-13 IPR002110; IPR020683; IPR021939; KN motif and ankyrin repeat domain-containing protein 3 (Ankyrin repeat domain-containing protein 47) KANK3 ANKRD47 Homo sapiens (Human) TR28775_c7_g1_i3 Q86U02 CN165_HUMAN 4.00E-25 GO:0016021 integral to membrane Putative uncharacterized protein encoded by LINC00596 LINC00596 C14orf165 Homo sapiens (Human) TR28775_c7_g1_i4 Q8N976 YG039_HUMAN 1.00E-13 Putative uncharacterized protein FLJ38264 Homo sapiens (Human) TR28775_c7_g1_i5 Q96NF6 CH049_HUMAN 3.00E-09 GO:0016021 integral to membrane Putative uncharacterized protein C8orf49 C8orf49 Homo sapiens (Human) TR28775_c7_g1_i6 Q8WTZ3 YS049_HUMAN 2.00E-24 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR013087; Zinc finger protein ENSP00000375192 Homo sapiens (Human) TR28776_c1_g1_i1 O43299 AP5Z1_HUMAN 1.00E-58 GO:0044599; GO:0030119; GO:0008219; GO:0000724; GO:0016197; GO:0005730; GO:0015031 AP-5 adaptor complex; AP-type membrane coat adaptor complex; cell death; double-strand break repair via homologous recombination; endosomal transport; nucleolus; protein transport IPR028222; AP-5 complex subunit zeta-1 (Adapter-related protein complex 5 zeta subunit) (Zeta5) AP5Z1 KIAA0415 SPG48 Homo sapiens (Human) TR28776_c1_g1_i2 O43299 AP5Z1_HUMAN 7.00E-50 GO:0044599; GO:0030119; GO:0008219; GO:0000724; GO:0016197; GO:0005730; GO:0015031 AP-5 adaptor complex; AP-type membrane coat adaptor complex; cell death; double-strand break repair via homologous recombination; endosomal transport; nucleolus; protein transport IPR028222; AP-5 complex subunit zeta-1 (Adapter-related protein complex 5 zeta subunit) (Zeta5) AP5Z1 KIAA0415 SPG48 Homo sapiens (Human) TR28779_c0_g1_i2 Q5RB31 SC61B_PONAB 5.00E-23 GO:0030433; GO:0031205; GO:0016021; GO:0000060; GO:0030970 "ER-associated protein catabolic process; endoplasmic reticulum Sec complex; integral to membrane; protein import into nucleus, translocation; retrograde protein transport, ER to cytosol" IPR016482; Protein transport protein Sec61 subunit beta SEC61B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR28780_c0_g1_i1 P34743 BTG1_CHICK 6.00E-39 GO:0005737; GO:0019899; GO:0008285; GO:0005634; GO:0045766; GO:0045603; GO:2000271; GO:0045663 cytoplasm; enzyme binding; negative regulation of cell proliferation; nucleus; positive regulation of angiogenesis; positive regulation of endothelial cell differentiation; positive regulation of fibroblast apoptotic process; positive regulation of myoblast differentiation IPR002087; Protein BTG1 (B-cell translocation gene 1 protein) BTG1 Gallus gallus (Chicken) TR28781_c12_g1_i2 Q9UPV0 CE164_HUMAN 5.00E-09 GO:0006281; GO:0000086; GO:0051301; GO:0005814; GO:0005929; GO:0042384; GO:0005829; GO:0007067; GO:0005634 Q53HC0; Q92997; Q7Z494; Q6IQ55 DNA repair; G2/M transition of mitotic cell cycle; cell division; centriole; cilium; cilium assembly; cytosol; mitosis; nucleus IPR001202; Centrosomal protein of 164 kDa (Cep164) CEP164 KIAA1052 NPHP15 Homo sapiens (Human) TR28786_c0_g1_i1 Q1LUA8 EI3EB_DANRE 0 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0005634; GO:0006446; GO:0003743; GO:0006413 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; nucleus; regulation of translational initiation; translation initiation factor activity; translational initiation IPR016650; IPR019010; IPR000717; IPR011991; Eukaryotic translation initiation factor 3 subunit E-B (eIF3e-B) (Eukaryotic translation initiation factor 3 subunit 6-B) eif3eb eif3s6b si:ch211-129b17.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR28787_c1_g2_i1 Q9Y6C2 EMIL1_HUMAN 1.00E-06 GO:0007155; GO:0005581; GO:0030023; GO:0030198; GO:0070062; GO:0010811 cell adhesion; collagen; extracellular matrix constituent conferring elasticity; extracellular matrix organization; extracellular vesicular exosome; positive regulation of cell-substrate adhesion IPR001073; IPR008160; IPR011489; IPR008983; EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1) EMILIN1 EMI Homo sapiens (Human) TR28788_c0_g1_i1 Q91WL8 WWOX_MOUSE 2.00E-15 GO:0005794; GO:0016055; GO:0071560; GO:0005829; GO:0097191; GO:0072332; GO:0005902; GO:0005739; GO:0030178; GO:0005634; GO:0001649; GO:0016491; GO:0005886; GO:2001241; GO:0045944; GO:0048705 Golgi apparatus; Wnt receptor signaling pathway; cellular response to transforming growth factor beta stimulus; cytosol; extrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; microvillus; mitochondrion; negative regulation of Wnt receptor signaling pathway; nucleus; osteoblast differentiation; oxidoreductase activity; plasma membrane; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of transcription from RNA polymerase II promoter; skeletal system morphogenesis IPR002198; IPR002347; IPR016040; IPR001202; WW domain-containing oxidoreductase (EC 1.1.1.-) Wwox Wox1 Mus musculus (Mouse) TR28788_c1_g1_i1 A2RVM0 TIC32_ARATH 8.00E-16 GO:0009706; GO:0016491; GO:0005886; GO:0015031 chloroplast inner membrane; oxidoreductase activity; plasma membrane; protein transport IPR002198; IPR002347; IPR016040; "Short-chain dehydrogenase TIC 32, chloroplastic (EC 1.1.1.-) (Translocon at the inner envelope membrane of chloroplasts 32) (AtTIC32)" TIC32 At4g23430 F16G20.130 Arabidopsis thaliana (Mouse-ear cress) TR28790_c0_g1_i1 Q5R5M4 MOT9_PONAB 5.00E-38 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 MCT9 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR28790_c0_g1_i3 Q5R5M4 MOT9_PONAB 6.00E-38 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 MCT9 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR28792_c1_g1_i1 O62640 PIAP_PIG 6.00E-08 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR28792_c3_g1_i1 P16423 POLR_DROME 1.00E-08 GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0046872; GO:0090305; GO:0006508 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR000477; IPR007087; IPR015880; Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM (Retrovirus-related Pol polyprotein from type II retrotransposable element R2DM) [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR28796_c3_g1_i1 Q63942 RAB3D_RAT 5.00E-09 GO:0005525; GO:0006887; GO:0005886; GO:0015031; GO:0007264; GO:0030133 GTP binding; exocytosis; plasma membrane; protein transport; small GTPase mediated signal transduction; transport vesicle IPR027417; IPR005225; IPR001806; IPR003579; GTP-binding protein Rab-3D Rab3d Rab16 Rattus norvegicus (Rat) TR28800_c4_g1_i1 Q5ZIE8 MCAF1_CHICK 7.00E-30 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR026085; IPR003961; IPR013783; Activating transcription factor 7-interacting protein 1 (MBD1-containing chromatin-associated factor 1) ATF7IP MCAF1 RCJMB04_27g4 Gallus gallus (Chicken) TR28801_c3_g2_i2 Q8IYS1 P20D2_HUMAN 6.00E-73 GO:0016787 hydrolase activity IPR017144; IPR002933; IPR011650; Peptidase M20 domain-containing protein 2 (Aminoacylase-1-like protein 2) PM20D2 ACY1L2 Homo sapiens (Human) TR28801_c3_g3_i2 A3KG59 P20D2_MOUSE 2.00E-22 GO:0016787 hydrolase activity IPR017439; IPR017144; IPR011650; Peptidase M20 domain-containing protein 2 (Aminoacylase-1-like protein 2) Pm20d2 Acy1l2 Gm424 Mus musculus (Mouse) TR28802_c0_g1_i1 Q9JKW1 TIM22_RAT 1.00E-17 GO:0016021; GO:0005743; GO:0015031 integral to membrane; mitochondrial inner membrane; protein transport IPR003397; Mitochondrial import inner membrane translocase subunit Tim22 Timm22 Tim22 Rattus norvegicus (Rat) TR28803_c1_g1_i1 P24369 PPIB_MOUSE 2.00E-36 GO:0005788; GO:0042470; GO:0042277; GO:0003755; GO:0006457; GO:0000413 endoplasmic reticulum lumen; melanosome; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) Ppib Mus musculus (Mouse) TR28805_c2_g1_i1 Q0IP28 LAC25_ORYSJ 1.00E-19 GO:0048046; GO:0005507; GO:0052716; GO:0046274 apoplast; copper ion binding; hydroquinone:oxygen oxidoreductase activity; lignin catabolic process IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; IPR017761; Laccase-25 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 25) (Diphenol oxidase 25) (Urishiol oxidase 25) LAC25 Os12g0259800 LOC_Os12g15920 Oryza sativa subsp. japonica (Rice) TR28805_c3_g1_i1 B4JTF5 HH_DROGR 3.00E-28 GO:0009653; GO:0045168; GO:0005737; GO:0005615; GO:0016539; GO:0016015; GO:0005634; GO:0008233; GO:0005886; GO:0006508; GO:0007367 anatomical structure morphogenesis; cell-cell signaling involved in cell fate commitment; cytoplasm; extracellular space; intein-mediated protein splicing; morphogen activity; nucleus; peptidase activity; plasma membrane; proteolysis; segment polarity determination IPR001657; IPR009045; IPR000320; IPR001767; IPR003586; IPR003587; IPR006141; Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product] hh GH23852 Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) TR28805_c4_g1_i1 P56193 LAC1_THACU 4.00E-20 GO:0005507; GO:0005576; GO:0052716; GO:0046274 copper ion binding; extracellular region; hydroquinone:oxygen oxidoreductase activity; lignin catabolic process IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; Laccase-1 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 1) (Diphenol oxidase 1) (Urishiol oxidase 1) LCC1 Thanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani) TR28808_c1_g1_i1 Q13257 MD2L1_HUMAN 2.00E-56 GO:0031145; GO:0051301; GO:0000777; GO:0005829; GO:0000776; GO:0000070; GO:0072686; GO:0007094; GO:0043066; GO:0060564; GO:0005634; GO:0048471; GO:0090267; GO:0000922 Itself; P78536; Q12834; Q9Y6D9; Q15013; Q562F6 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; condensed chromosome kinetochore; cytosol; kinetochore; mitotic sister chromatid segregation; mitotic spindle; mitotic spindle assembly checkpoint; negative regulation of apoptotic process; negative regulation of mitotic anaphase-promoting complex activity; nucleus; perinuclear region of cytoplasm; positive regulation of mitotic cell cycle spindle assembly checkpoint; spindle pole IPR003511; IPR027097; Mitotic spindle assembly checkpoint protein MAD2A (HsMAD2) (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1) MAD2L1 MAD2 Homo sapiens (Human) TR28809_c0_g1_i1 Q1L6Q1 DUSTY_APIME 3.00E-22 GO:0005524; GO:0005737; GO:0018108; GO:0004674; GO:0004712; GO:0004713 ATP binding; cytoplasm; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (Receptor-interacting serine/threonine-protein kinase 5) DSTYK RIPK5 Apis mellifera (Honeybee) TR28810_c0_g1_i1 Q9J517 V218_FOWPN 1.00E-12 IPR002110; IPR020683; IPR018272; Putative ankyrin repeat protein FPV218 FPV218 Fowlpox virus (strain NVSL) (FPV) TR28814_c0_g1_i1 P0DKQ8 ACTP_CONCN 1.00E-28 GO:0019835; GO:0044179; GO:0016021; GO:0006811; GO:0044218 cytolysis; hemolysis in other organism; integral to membrane; ion transport; other organism cell membrane IPR015926; Conoporin-Cn1 Conus consors (Singed cone) TR28817_c2_g3_i1 Q14703 MBTP1_HUMAN 0 GO:0000139; GO:0005795; GO:0006987; GO:0044267; GO:0008203; GO:0005788; GO:0005789; GO:0016021; GO:0006629; GO:0006508; GO:0042990; GO:0004252; GO:0044281 Golgi membrane; Golgi stack; activation of signaling protein activity involved in unfolded protein response; cellular protein metabolic process; cholesterol metabolic process; endoplasmic reticulum lumen; endoplasmic reticulum membrane; integral to membrane; lipid metabolic process; proteolysis; regulation of transcription factor import into nucleus; serine-type endopeptidase activity; small molecule metabolic process IPR000209; IPR022398; IPR023828; IPR015500; Membrane-bound transcription factor site-1 protease (EC 3.4.21.112) (Endopeptidase S1P) (Subtilisin/kexin-isozyme 1) (SKI-1) MBTPS1 KIAA0091 S1P SKI1 Homo sapiens (Human) TR28818_c1_g1_i1 P0C026 NUD24_ARATH 2.00E-49 GO:0009507; GO:0016787; GO:0046872 chloroplast; hydrolase activity; metal ion binding IPR000086; IPR015797; "Nudix hydrolase 24, chloroplastic (AtNUDT24) (EC 3.6.1.-)" NUDT24 NUDX24 At5g19470 F7K24.220 Arabidopsis thaliana (Mouse-ear cress) TR28821_c2_g1_i2 Q2LK95 COL10_CHICK 5.00E-08 GO:0005581; GO:0005737; GO:0005537 collagen; cytoplasm; mannose binding IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-10 (Collectin-1) (CL-1) (cCL-1) COLEC10 CL1 Gallus gallus (Chicken) TR28821_c2_g1_i3 P82596 PLC_HALLA 7.00E-18 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR28825_c0_g1_i1 Q86WZ0 HEAT4_HUMAN 2.00E-37 IPR011989; IPR016024; IPR000357; HEAT repeat-containing protein 4 HEATR4 Homo sapiens (Human) TR28826_c0_g1_i1 A6BM06 ACCO1_DICMU 5.00E-15 GO:0009815; GO:0009693; GO:0005506; GO:0016706 "1-aminocyclopropane-1-carboxylate oxidase activity; ethylene biosynthetic process; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" IPR026992; IPR027443; IPR002283; IPR005123; Alkene biosynthesis; ethylene biosynthesis via S-adenosyl-L-methionine; ethylene from S-adenosyl-L-methionine: step 2/2. 1-aminocyclopropane-1-carboxylate oxidase (ACC oxidase) (Dmaco) (EC 1.14.17.4) (Ethylene-forming enzyme) (EFE) aco Dictyostelium mucoroides (Slime mold) TR28826_c0_g1_i2 Q7LL04 YQK1_SCHPO 2.00E-26 GO:0005829; GO:0005634; GO:0016706 "cytosol; nucleus; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" IPR026992; IPR027443; IPR005123; UPF0676 protein C1494.01 SPCC1494.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR28826_c0_g1_i3 Q54RA4 Y3291_DICDI 1.00E-11 GO:0005506; GO:0016706 "iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" IPR026992; IPR027443; IPR002283; IPR005123; Probable iron/ascorbate oxidoreductase DDB_G0283291 (EC 1.14.-.-) DDB_G0283291 Dictyostelium discoideum (Slime mold) TR28826_c0_g1_i4 A6BM06 ACCO1_DICMU 4.00E-11 GO:0009815; GO:0009693; GO:0005506; GO:0016706 "1-aminocyclopropane-1-carboxylate oxidase activity; ethylene biosynthetic process; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" IPR026992; IPR027443; IPR002283; IPR005123; Alkene biosynthesis; ethylene biosynthesis via S-adenosyl-L-methionine; ethylene from S-adenosyl-L-methionine: step 2/2. 1-aminocyclopropane-1-carboxylate oxidase (ACC oxidase) (Dmaco) (EC 1.14.17.4) (Ethylene-forming enzyme) (EFE) aco Dictyostelium mucoroides (Slime mold) TR28827_c4_g1_i1 Q5T4J0 GCNT6_HUMAN 2.00E-11 GO:0000139; GO:0008375; GO:0016021; GO:0006486 Golgi membrane; acetylglucosaminyltransferase activity; integral to membrane; protein glycosylation IPR003406; Protein modification; protein glycosylation. "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 6 (EC 2.4.1.-)" GCNT6 Homo sapiens (Human) TR28827_c5_g1_i1 O95395 GCNT3_HUMAN 3.00E-27 GO:0000139; GO:0008109; GO:0016266; GO:0047225; GO:0003829; GO:0002426; GO:0016021; GO:0050892; GO:0060993; GO:0043687; GO:0048729 "Golgi membrane; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity; O-glycan processing; acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; immunoglobulin production in mucosal tissue; integral to membrane; intestinal absorption; kidney morphogenesis; post-translational protein modification; tissue morphogenesis" IPR003406; Protein modification; protein glycosylation. "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (EC 2.4.1.102) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M) (hC2GnT-M) (Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase) (C2/4GnT)" GCNT3 Homo sapiens (Human) TR28828_c0_g1_i1 Q4R372 FBX25_MACFA 4.00E-52 GO:0019005; GO:0005634; GO:0016567 SCF ubiquitin ligase complex; nucleus; protein ubiquitination IPR001810; Protein modification; protein ubiquitination. F-box only protein 25 FBXO25 QtsA-19104 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR28829_c6_g2_i2 Q29RP1 UBP1_BOVIN 2.00E-32 GO:0006281; GO:0035520; GO:0005634; GO:0006282; GO:0009411; GO:0004221; GO:0006511; GO:0004843 DNA repair; monoubiquitinated protein deubiquitination; nucleus; regulation of DNA repair; response to UV; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) USP1 Bos taurus (Bovine) TR28830_c0_g1_i1 Q9CX47 XRCC2_MOUSE 2.00E-25 GO:0005524; GO:0003677; GO:0008094; GO:0000724; GO:0001701; GO:0043524; GO:0005634; GO:0050769; GO:0010165; GO:0010332 ATP binding; DNA binding; DNA-dependent ATPase activity; double-strand break repair via homologous recombination; in utero embryonic development; negative regulation of neuron apoptotic process; nucleus; positive regulation of neurogenesis; response to X-ray; response to gamma radiation IPR013632; IPR020588; IPR027417; DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2) Xrcc2 Mus musculus (Mouse) TR28830_c4_g1_i1 Q5UPG5 YL093_MIMIV 1.00E-27 IPR002110; IPR020683; Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) TR28830_c5_g1_i3 Q9VFD5 FEM1A_DROME 7.00E-18 GO:0051438; GO:0004842 regulation of ubiquitin-protein ligase activity; ubiquitin-protein ligase activity IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog CG6966 CG6966 Drosophila melanogaster (Fruit fly) TR28830_c5_g1_i4 Q07DX4 CTTB2_NOMLE 4.00E-13 GO:0005938; GO:0043197 cell cortex; dendritic spine IPR002110; IPR020683; IPR019131; Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) TR28830_c5_g1_i5 Q09YG9 CTTB2_SAIBB 8.00E-14 GO:0005938; GO:0043197 cell cortex; dendritic spine IPR002110; IPR020683; IPR019131; Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Saimiri boliviensis boliviensis (Bolivian squirrel monkey) TR28832_c0_g2_i2 Q14517 FAT1_HUMAN 1.00E-06 GO:0007015; GO:0009653; GO:0005509; GO:0016477; GO:0016337; GO:0005911; GO:0007267; GO:0007163; GO:0030175; GO:0007156; GO:0005887; GO:0030027; GO:0005634; GO:0048471 Q8N8S7; Q9NSC5; Q99JP6 actin filament organization; anatomical structure morphogenesis; calcium ion binding; cell migration; cell-cell adhesion; cell-cell junction; cell-cell signaling; establishment or maintenance of cell polarity; filopodium; homophilic cell adhesion; integral to plasma membrane; lamellipodium; nucleus; perinuclear region of cytoplasm IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) TR28833_c1_g2_i1 Q9H1A4 APC1_HUMAN 0 GO:0005680; GO:0031145; GO:0051301; GO:0005829; GO:0007067; GO:0007094; GO:0051436; GO:0005654; GO:0051437; GO:0070979 anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; cytosol; mitosis; mitotic spindle assembly checkpoint; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; protein K11-linked ubiquitination IPR024990; Protein modification; protein ubiquitination. Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) ANAPC1 TSG24 Homo sapiens (Human) TR28834_c0_g1_i1 Q92615 LAR4B_HUMAN 3.00E-60 GO:0003723; GO:0010494; GO:0005829; GO:0042788; GO:0045727 RNA binding; cytoplasmic stress granule; cytosol; polysomal ribosome; positive regulation of translation IPR006630; IPR000504; IPR011991; La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) LARP4B KIAA0217 LARP5 Homo sapiens (Human) TR28836_c0_g1_i1 P55350 Y4AC_RHISN 1.00E-08 GO:0016117; GO:0016767 carotenoid biosynthetic process; geranylgeranyl-diphosphate geranylgeranyltransferase activity IPR002060; IPR017828; IPR019845; IPR008949; Putative phytoene synthase (EC 2.5.1.32) NGR_a00440 y4aC Rhizobium sp. (strain NGR234) TR28836_c0_g1_i2 A7YVD7 NDUF6_BOVIN 1.00E-86 GO:0009058; GO:0005743; GO:0032981; GO:0016740 biosynthetic process; mitochondrial inner membrane; mitochondrial respiratory chain complex I assembly; transferase activity IPR002060; IPR008949; "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6" NDUFAF6 Bos taurus (Bovine) TR28836_c0_g1_i4 P49293 PSY_CUCME 1.00E-07 GO:0016117; GO:0009507; GO:0016767 carotenoid biosynthetic process; chloroplast; geranylgeranyl-diphosphate geranylgeranyltransferase activity IPR002060; IPR019845; IPR008949; Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1. "Phytoene synthase, chloroplastic (EC 2.5.1.32) (MEL5)" PSY Cucumis melo (Muskmelon) TR28838_c0_g1_i1 Q5RE47 DX39B_PONAB 6.00E-129 GO:0005524; GO:0008026; GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0051028; GO:0016607; GO:0005681 ATP binding; ATP-dependent helicase activity; RNA binding; RNA splicing; cytoplasm; mRNA processing; mRNA transport; nuclear speck; spliceosomal complex IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (DEAD box protein UAP56) DDX39B BAT1 UAP56 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR28838_c0_g1_i2 Q6BL34 DBP10_DEBHA 3.00E-21 GO:0005524; GO:0008026; GO:0003723; GO:0005730; GO:0006364 ATP binding; ATP-dependent helicase activity; RNA binding; nucleolus; rRNA processing IPR012541; IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DBP10 (EC 3.6.4.13) DBP10 DEHA2F16720g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR28838_c0_g1_i4 Q06218 DBP9_YEAST 3.00E-17 GO:0005524; GO:0004003; GO:0033680; GO:0004004; GO:0003723; GO:0000463; GO:0005730 "ATP binding; ATP-dependent DNA helicase activity; ATP-dependent DNA/RNA helicase activity; ATP-dependent RNA helicase activity; RNA binding; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleolus" IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; ATP-dependent RNA helicase DBP9 (EC 3.6.4.13) (DEAD box protein 9) DBP9 YLR276C L9328.3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR28838_c0_g1_i5 Q5RE47 DX39B_PONAB 0 GO:0005524; GO:0008026; GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0051028; GO:0016607; GO:0005681 ATP binding; ATP-dependent helicase activity; RNA binding; RNA splicing; cytoplasm; mRNA processing; mRNA transport; nuclear speck; spliceosomal complex IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (DEAD box protein UAP56) DDX39B BAT1 UAP56 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR28839_c3_g1_i1 Q8K4S1 PLCE1_MOUSE 1.00E-14 GO:0000139; GO:0000187; GO:0005509; GO:0005829; GO:0019899; GO:0032835; GO:0005085; GO:0016042; GO:0004435; GO:0007200; GO:0005886; GO:0008277; GO:0046578; GO:0004871; GO:0007264 Golgi membrane; activation of MAPK activity; calcium ion binding; cytosol; enzyme binding; glomerulus development; guanyl-nucleotide exchange factor activity; lipid catabolic process; phosphatidylinositol phospholipase C activity; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; regulation of G-protein coupled receptor protein signaling pathway; regulation of Ras protein signal transduction; signal transducer activity; small GTPase mediated signal transduction IPR000008; IPR011992; IPR001192; IPR017946; IPR015359; IPR000909; IPR001711; IPR000159; IPR023578; IPR001895; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1)" Plce1 Kiaa1516 Plce Mus musculus (Mouse) TR28839_c5_g1_i1 Q07722 PLCB4_BOVIN 1.00E-07 GO:0005509; GO:0035556; GO:0016042; GO:0004435; GO:0004871 calcium ion binding; intracellular signal transduction; lipid catabolic process; phosphatidylinositol phospholipase C activity; signal transducer activity IPR000008; IPR011992; IPR001192; IPR016280; IPR009535; IPR017946; IPR015359; IPR000909; IPR001711; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (PCL-C1) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4) (Fragment)" PLCB4 Bos taurus (Bovine) TR28840_c0_g1_i1 Q28GF4 CF162_XENTR 1.00E-15 GO:0016021 integral to membrane IPR026686; Small integral membrane protein 8 smim8 TEgg033e03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28840_c0_g1_i2 Q9CQQ0 CF162_MOUSE 1.00E-15 GO:0016021 integral to membrane IPR026686; Small integral membrane protein 8 Smim8 Mus musculus (Mouse) TR28841_c0_g1_i2 Q8R331 ZNHI1_MOUSE 2.00E-29 GO:0003682; GO:0046872; GO:0070317; GO:0000122; GO:0005634; GO:0042129; GO:0031063 chromatin binding; metal ion binding; negative regulation of G0 to G1 transition; negative regulation of transcription from RNA polymerase II promoter; nucleus; regulation of T cell proliferation; regulation of histone deacetylation IPR007529; Zinc finger HIT domain-containing protein 1 Znhit1 Mus musculus (Mouse) TR28842_c0_g1_i1 Q9CQR5 ZMAT5_MOUSE 5.00E-25 GO:0008380; GO:0005689; GO:0005737; GO:0006397; GO:0008270 RNA splicing; U12-type spliceosomal complex; cytoplasm; mRNA processing; zinc ion binding IPR000571; IPR013085; Zinc finger matrin-type protein 5 (U11/U12 small nuclear ribonucleoprotein 20 kDa protein) (U11/U12 snRNP 20 kDa protein) Zmat5 D11Bwg1548e Mus musculus (Mouse) TR28842_c0_g1_i2 Q0JP11 C3H3_ORYSJ 2.00E-14 GO:0003677; GO:0008270 DNA binding; zinc ion binding IPR000571; IPR013085; Zinc finger CCCH domain-containing protein 3 (OsC3H3) Os01g0252200 LOC_Os01g14870 Oryza sativa subsp. japonica (Rice) TR28843_c0_g1_i1 Q4U3Q4 PPARG_CANFA 7.00E-22 GO:0003677; GO:0001012; GO:0006919; GO:0050873; GO:0045165; GO:0048469; GO:0032869; GO:0071285; GO:0003682; GO:0005829; GO:0008144; GO:0030855; GO:0042593; GO:0004879; GO:0030374; GO:0042953; GO:0015909; GO:0045713; GO:0030224; GO:0010887; GO:0060336; GO:0010871; GO:0010891; GO:0048662; GO:0000122; GO:0005634; GO:0035357; GO:0001890; GO:0045600; GO:0051091; GO:0045944; GO:0008217; GO:0055098; GO:0032526; GO:0043565; GO:0003707; GO:0050872; GO:0008270 DNA binding; RNA polymerase II regulatory region DNA binding; activation of cysteine-type endopeptidase activity involved in apoptotic process; brown fat cell differentiation; cell fate commitment; cell maturation; cellular response to insulin stimulus; cellular response to lithium ion; chromatin binding; cytosol; drug binding; epithelial cell differentiation; glucose homeostasis; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; ligand-dependent nuclear receptor transcription coactivator activity; lipoprotein transport; long-chain fatty acid transport; low-density lipoprotein particle receptor biosynthetic process; monocyte differentiation; negative regulation of cholesterol storage; negative regulation of interferon-gamma-mediated signaling pathway; negative regulation of receptor biosynthetic process; negative regulation of sequestering of triglyceride; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; nucleus; peroxisome proliferator activated receptor signaling pathway; placenta development; positive regulation of fat cell differentiation; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of blood pressure; response to low-density lipoprotein particle stimulus; response to retinoic acid; sequence-specific DNA binding; steroid hormone receptor activity; white fat cell differentiation; zinc ion binding IPR003074; IPR003077; IPR008946; IPR000536; IPR022590; IPR001723; IPR001628; IPR013088; Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) PPARG NR1C3 Canis familiaris (Dog) (Canis lupus familiaris) TR28844_c6_g1_i1 Q9XSC3 WDR44_BOVIN 7.00E-97 GO:0005794; GO:0005829; GO:0010008; GO:0048471 Golgi apparatus; cytosol; endosome membrane; perinuclear region of cytoplasm IPR020472; IPR015943; IPR001680; IPR017986; WD repeat-containing protein 44 (Rab11-binding protein) (Rabphilin-11) WDR44 RAB11BP Bos taurus (Bovine) TR28845_c4_g1_i1 B1AS42 NB5R5_MOUSE 4.00E-60 GO:0004128 "cytochrome-b5 reductase activity, acting on NAD(P)H" IPR017927; IPR001709; IPR001834; IPR019180; IPR008333; IPR001433; IPR017938; NADH-cytochrome b5 reductase-like (EC 1.6.2.2) Cyb5rl Mus musculus (Mouse) TR28845_c4_g1_i4 Q54NC1 NCB5R_DICDI 6.00E-42 GO:0004128; GO:0005789; GO:0016021; GO:0005741 "cytochrome-b5 reductase activity, acting on NAD(P)H; endoplasmic reticulum membrane; integral to membrane; mitochondrial outer membrane" IPR017927; IPR001709; IPR001834; IPR008333; IPR001433; IPR017938; NADH-cytochrome b5 reductase 1 (EC 1.6.2.2) cyb5r1 DDB_G0285399 Dictyostelium discoideum (Slime mold) TR28847_c0_g1_i1 P49005 DPOD2_HUMAN 8.00E-161 GO:0003677; GO:0006271; GO:0003887; GO:0006284; GO:0000278; GO:0005654; GO:0006297; GO:0000722; GO:0032201; GO:0006283 P28340; Q15054; Q9HCU8; Q96S55 "DNA binding; DNA strand elongation involved in DNA replication; DNA-directed DNA polymerase activity; base-excision repair; mitotic cell cycle; nucleoplasm; nucleotide-excision repair, DNA gap filling; telomere maintenance via recombination; telomere maintenance via semi-conservative replication; transcription-coupled nucleotide-excision repair" IPR007185; IPR024826; DNA polymerase delta subunit 2 (EC 2.7.7.7) (DNA polymerase delta subunit p50) POLD2 Homo sapiens (Human) TR28848_c4_g1_i2 Q8R4G6 MGT5A_MOUSE 1.00E-75 GO:0000139; GO:0008375; GO:0030144; GO:0016021; GO:0006487 "Golgi membrane; acetylglucosaminyltransferase activity; alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity; integral to membrane; protein N-linked glycosylation" IPR027833; IPR026116; Protein modification; protein glycosylation. "Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.155) (Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase) (GlcNAc-T V) (GNT-V) (Mannoside acetylglucosaminyltransferase 5) (N-acetylglucosaminyl-transferase V)" Mgat5 Mus musculus (Mouse) TR28848_c5_g1_i1 Q8R4G6 MGT5A_MOUSE 3.00E-50 GO:0000139; GO:0008375; GO:0030144; GO:0016021; GO:0006487 "Golgi membrane; acetylglucosaminyltransferase activity; alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity; integral to membrane; protein N-linked glycosylation" IPR027833; IPR026116; Protein modification; protein glycosylation. "Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.155) (Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase) (GlcNAc-T V) (GNT-V) (Mannoside acetylglucosaminyltransferase 5) (N-acetylglucosaminyl-transferase V)" Mgat5 Mus musculus (Mouse) TR28853_c0_g1_i1 P33748 MSN2_YEAST 5.00E-08 GO:0000982; GO:0001324; GO:0071483; GO:0071406; GO:0006338; GO:0000987; GO:0005829; GO:0046872; GO:0005634; GO:0061401; GO:0061402; GO:0061422; GO:0061412; GO:0061395; GO:0061410; GO:0061409; GO:0061406; GO:0061408; GO:0061407; GO:0061405; GO:0061404; GO:0061403; GO:0097236; GO:0061434; GO:0001302 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity; age-dependent response to oxidative stress involved in chronological cell aging; cellular response to blue light; cellular response to methylmercury; chromatin remodeling; core promoter proximal region sequence-specific DNA binding; cytosol; metal ion binding; nucleus; positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment; positive regulation of transcription from RNA polymerase II promoter in response to acidity; positive regulation of transcription from RNA polymerase II promoter in response to alkalinity; positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation; positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance; positive regulation of transcription from RNA polymerase II promoter in response to ethanol; positive regulation of transcription from RNA polymerase II promoter in response to freezing; positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation; positive regulation of transcription from RNA polymerase II promoter in response to heat stress; positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide; positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure; positive regulation of transcription from RNA polymerase II promoter in response to increased salt; positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress; positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation; regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction; replicative cell aging IPR007087; IPR015880; IPR013087; Zinc finger protein MSN2 (Multicopy suppressor of SNF1 protein 2) MSN2 YMR037C YM9532.02C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR28853_c0_g2_i1 P39770 SALM_DROME 1.00E-25 GO:0003677; GO:0045466; GO:0045465; GO:0048098; GO:0046845; GO:0007427; GO:0008586; GO:0030539; GO:0008584; GO:0046872; GO:0048644; GO:0045892; GO:0035310; GO:0005634; GO:0007438; GO:0042659; GO:0007605; GO:0007525; GO:0035277; GO:0006351 "DNA binding; R7 cell differentiation; R8 cell differentiation; antennal joint development; branched duct epithelial cell fate determination, open tracheal system; epithelial cell migration, open tracheal system; imaginal disc-derived wing vein morphogenesis; male genitalia development; male gonad development; metal ion binding; muscle organ morphogenesis; negative regulation of transcription, DNA-dependent; notum cell fate specification; nucleus; oenocyte development; regulation of cell fate specification; sensory perception of sound; somatic muscle development; spiracle morphogenesis, open tracheal system; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Homeotic protein spalt-major salm sal CG6464 Drosophila melanogaster (Fruit fly) TR28853_c2_g1_i1 Q62255 SALL3_MOUSE 1.00E-30 GO:0003677; GO:0035136; GO:0035137; GO:0046872; GO:0045879; GO:0005634; GO:0021891; GO:0006355; GO:0006351 "DNA binding; forelimb morphogenesis; hindlimb morphogenesis; metal ion binding; negative regulation of smoothened signaling pathway; nucleus; olfactory bulb interneuron development; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Sal-like protein 3 (MSal) (Spalt-like protein 3) Sall3 Sal Mus musculus (Mouse) TR28855_c0_g1_i1 Q9Y3D9 RT23_HUMAN 3.00E-27 GO:0045111; GO:0005739; GO:0031965; GO:0005840; GO:0003735; GO:0006412 intermediate filament cytoskeleton; mitochondrion; nuclear membrane; ribosome; structural constituent of ribosome; translation IPR023611; IPR019520; "28S ribosomal protein S23, mitochondrial (MRP-S23) (S23mt)" MRPS23 CGI-138 HSPC329 Homo sapiens (Human) TR28858_c0_g1_i1 Q9VS29 DSCL_DROME 2.00E-06 GO:0007156; GO:0005887; GO:0048812 homophilic cell adhesion; integral to plasma membrane; neuron projection morphogenesis IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Down syndrome cell adhesion molecule-like protein Dscam2 Dscam2 CG42256 Drosophila melanogaster (Fruit fly) TR28858_c0_g1_i2 Q26474 LACH_SCHAM 6.00E-07 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Lachesin LAC Schistocerca americana (American grasshopper) TR28863_c0_g1_i1 Q9QY93 DCTP1_MOUSE 5.00E-44 GO:0005829; GO:0047840; GO:0000287; GO:0009143; GO:0047429; GO:0051289; GO:0032556 cytosol; dCTP diphosphatase activity; magnesium ion binding; nucleoside triphosphate catabolic process; nucleoside-triphosphate diphosphatase activity; protein homotetramerization; pyrimidine deoxyribonucleotide binding IPR009039; IPR004518; dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21-C6) (XTP3-transactivated gene A protein homolog) Dctpp1 Tdrg-TL1 Mus musculus (Mouse) TR28867_c1_g1_i1 Q91WQ5 TAF5L_MOUSE 2.00E-13 GO:0030914; GO:0043966; GO:0004402; GO:0006355; GO:0003713; GO:0033276; GO:0006351 "STAGA complex; histone H3 acetylation; histone acetyltransferase activity; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription factor TFTC complex; transcription, DNA-dependent" IPR020472; IPR007582; IPR015943; IPR001680; IPR019775; IPR017986; TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65-beta) Taf5l Paf65b Mus musculus (Mouse) TR28867_c1_g1_i2 A2RRH5 WDR27_HUMAN 2.00E-53 IPR011047; IPR015943; IPR001680; IPR017986; WD repeat-containing protein 27 WDR27 Homo sapiens (Human) TR28868_c0_g1_i1 Q5HZP1 RNH2B_XENLA 1.00E-55 GO:0006401; GO:0005634; GO:0032299 RNA catabolic process; nucleus; ribonuclease H2 complex IPR019024; Ribonuclease H2 subunit B (RNase H2 subunit B) (Ribonuclease HI subunit B) rnaseh2b Xenopus laevis (African clawed frog) TR28869_c0_g1_i1 P08051 MLR_SPISA 3.00E-56 GO:0005509; GO:0016459 calcium ion binding; myosin complex IPR011992; IPR018247; IPR002048; "Myosin regulatory light chain, smooth muscle" Spisula sachalinensis (Sakhalin surf-clam) TR28870_c0_g1_i1 P48353 HLJ1_YEAST 1.00E-14 GO:0001671; GO:0030433; GO:0005789 ATPase activator activity; ER-associated protein catabolic process; endoplasmic reticulum membrane IPR001623; IPR018253; Protein HLJ1 HLJ1 YMR161W YM8520.10 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR28874_c1_g1_i1 Q9UA35 S28A3_EPTST 2.00E-78 GO:0016021; GO:0005415 integral to membrane; nucleoside:sodium symporter activity IPR008276; IPR018270; IPR011657; IPR002668; Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT) SLC28A3 CNT3 Eptatretus stoutii (Pacific hagfish) TR28874_c1_g1_i2 P39141 NUPC_BACSU 3.00E-10 GO:0016021; GO:0005415; GO:0005886 integral to membrane; nucleoside:sodium symporter activity; plasma membrane IPR008276; IPR018270; IPR011657; IPR002668; Pyrimidine nucleoside transport protein nupC BSU39410 Bacillus subtilis (strain 168) TR28877_c4_g1_i1 Q10002 APN1_CAEEL 2.00E-31 GO:0003677; GO:0003906; GO:0006284; GO:0004519; GO:0005634; GO:0008081; GO:0008270 DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; base-excision repair; endonuclease activity; nucleus; phosphoric diester hydrolase activity; zinc ion binding IPR001719; IPR018246; IPR013022; DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (Apurinic-apyrimidinic endonuclease) (AP endonuclease) apn-1 T05H10.2 Caenorhabditis elegans TR28878_c1_g1_i1 Q24323 SEM2A_DROME 1.00E-35 GO:0007411; GO:0070983; GO:0042756; GO:0005576; GO:0007629; GO:0016020; GO:0004872; GO:0016201; GO:0007632 axon guidance; dendrite guidance; drinking behavior; extracellular region; flight behavior; membrane; receptor activity; synaptic target inhibition; visual behavior IPR007110; IPR013783; IPR003599; IPR016201; IPR001627; IPR027231; IPR015943; Semaphorin-2A (Semaphorin-II) (Sema II) Sema-2a dSema-II CG4700 Drosophila melanogaster (Fruit fly) TR28881_c1_g1_i1 Q01799 ESCA_SCICO 1.00E-09 GO:0003677; GO:0046872; GO:0005634 DNA binding; metal ion binding; nucleus IPR007087; IPR015880; IPR013087; Escargot/snail protein homolog (Fragment) Sciara coprophila (Fungus gnat) TR28881_c1_g2_i1 Q24732 GLAS_DROVI 8.00E-32 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0050896; GO:0006351; GO:0007601 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; response to stimulus; transcription, DNA-dependent; visual perception" IPR007087; IPR015880; IPR013087; Protein glass gl GJ10836 Drosophila virilis (Fruit fly) TR28881_c1_g2_i2 Q9QZP2 PRDM4_RAT 2.00E-53 GO:0003677; GO:0071363; GO:0031670; GO:0005829; GO:0046872; GO:0008168; GO:0030308; GO:0005654; GO:0006355; GO:0006351 "DNA binding; cellular response to growth factor stimulus; cellular response to nutrient; cytosol; metal ion binding; methyltransferase activity; negative regulation of cell growth; nucleoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001214; IPR007087; IPR015880; IPR013087; IPR017124; PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4) Prdm4 Rattus norvegicus (Rat) TR28881_c1_g2_i3 Q9QZ48 ZBT7A_RAT 3.00E-23 GO:0003677; GO:0030154; GO:0035035; GO:0046872; GO:0007275; GO:0045892; GO:0005634; GO:0045670; GO:0003700; GO:0006351 "DNA binding; cell differentiation; histone acetyltransferase binding; metal ion binding; multicellular organismal development; negative regulation of transcription, DNA-dependent; nucleus; regulation of osteoclast differentiation; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma-related factor) (Osteoclast-derived zinc finger protein) Zbtb7a Lrf Oczf Zbtb7 Rattus norvegicus (Rat) TR28881_c2_g1_i1 Q9H4Q4 PRD12_HUMAN 2.00E-16 GO:0003677; GO:0046872; GO:0008168; GO:0022008; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; methyltransferase activity; neurogenesis; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001214; IPR007087; IPR015880; IPR013087; IPR017126; PR domain zinc finger protein 12 (EC 2.1.1.-) (PR domain-containing protein 12) PRDM12 PFM9 Homo sapiens (Human) TR28882_c1_g1_i1 Q9DE07 NBN_CHICK 2.00E-49 GO:0030870; GO:0000781; GO:0000724; GO:0007126; GO:0007095; GO:0042405; GO:0005654; GO:0047485; GO:0048145; GO:0000723; GO:0008134 "Mre11 complex; chromosome, telomeric region; double-strand break repair via homologous recombination; meiosis; mitotic G2 DNA damage checkpoint; nuclear inclusion body; nucleoplasm; protein N-terminus binding; regulation of fibroblast proliferation; telomere maintenance; transcription factor binding" IPR001357; IPR013908; IPR000253; IPR016592; IPR008984; Nibrin (Nijmegen breakage syndrome protein 1 homolog) NBN NBS1 Gallus gallus (Chicken) TR28883_c0_g1_i1 Q9V3H2 PSDE_DROME 0 GO:0046872; GO:0008237; GO:0005875; GO:0032436; GO:0043161; GO:0008541 "metal ion binding; metallopeptidase activity; microtubule associated complex; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; proteasome regulatory particle, lid subcomplex" IPR000555; IPR024969; 26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory complex subunit p37B) (26S proteasome regulatory subunit rpn11) (Yippee-interacting protein 5) Rpn11 yip5 CG18174 Drosophila melanogaster (Fruit fly) TR28885_c1_g1_i1 A7YY07 CS066_DANRE 2.00E-28 IPR026795; UPF0515 protein C19orf66 homolog zgc:171711 Danio rerio (Zebrafish) (Brachydanio rerio) TR28885_c1_g1_i2 A0JP89 CS066_XENTR 4.00E-34 IPR026795; UPF0515 protein C19orf66 homolog Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28886_c1_g1_i2 Q9US35 DSD1_SCHPO 3.00E-39 GO:0008721; GO:0008784; GO:0005829; GO:0071852; GO:0005634 D-serine ammonia-lyase activity; alanine racemase activity; cytosol; fungal-type cell wall organization or biogenesis; nucleus IPR001608; IPR026956; D-serine dehydratase (EC 4.3.1.18) (D-serine deaminase) (DSD) SPAC1039.06 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR28888_c2_g2_i1 O18875 SC6A8_BOVIN 2.00E-67 GO:0005309; GO:0005887; GO:0005328 creatine:sodium symporter activity; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR002984; Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8) SLC6A8 Bos taurus (Bovine) TR28891_c1_g1_i2 P32240 PE2R4_MOUSE 6.00E-44 GO:0070371; GO:0007254; GO:0042093; GO:0007189; GO:0060348; GO:0071260; GO:0016021; GO:0050710; GO:2000420; GO:0050728; GO:0033624; GO:0005886; GO:0050715; GO:0050729; GO:0004957; GO:0030278; GO:0051492; GO:0032496 ERK1 and ERK2 cascade; JNK cascade; T-helper cell differentiation; adenylate cyclase-activating G-protein coupled receptor signaling pathway; bone development; cellular response to mechanical stimulus; integral to membrane; negative regulation of cytokine secretion; negative regulation of eosinophil extravasation; negative regulation of inflammatory response; negative regulation of integrin activation; plasma membrane; positive regulation of cytokine secretion; positive regulation of inflammatory response; prostaglandin E receptor activity; regulation of ossification; regulation of stress fiber assembly; response to lipopolysaccharide IPR000276; IPR017452; IPR001758; IPR008365; IPR001244; Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) Ptger4 Ptgerep4 Mus musculus (Mouse) TR28892_c1_g2_i1 Q5XJ34 KC15L_DANRE 7.00E-12 GO:0044335; GO:0090090; GO:0060037; GO:0051260 canonical Wnt receptor signaling pathway involved in neural crest cell differentiation; negative regulation of canonical Wnt receptor signaling pathway; pharyngeal system development; protein homooligomerization IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein kctd15-like kctd15l zgc:103747 Danio rerio (Zebrafish) (Brachydanio rerio) TR28895_c0_g1_i2 Q9EQ15 GNB1L_MOUSE 5.00E-56 GO:0005737; GO:0035176 cytoplasm; social behavior IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Guanine nucleotide-binding protein subunit beta-like protein 1 (G protein subunit beta-like protein 1) (WD repeat-containing protein 14) (WD40 repeat-containing protein deleted in VCFS) (WDVCF) Gnb1l Estm55 Wdr14 Mus musculus (Mouse) TR28898_c1_g1_i1 Q9H3G5 CPVL_HUMAN 3.00E-174 GO:0006508; GO:0004185 proteolysis; serine-type carboxypeptidase activity IPR001563; IPR018202; "Probable serine carboxypeptidase CPVL (EC 3.4.16.-) (Carboxypeptidase, vitellogenic-like) (Vitellogenic carboxypeptidase-like protein) (VCP-like protein) (hVLP)" CPVL VLP PSEC0124 UNQ197/PRO223 Homo sapiens (Human) TR28902_c0_g1_i1 P86789 GIGA6_CRAGI 2.00E-40 GO:0016021 integral to membrane IPR001466; IPR012338; Gigasin-6 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) TR28902_c0_g2_i1 Q7A3Q5 FLP_STAAN 7.00E-14 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR001466; IPR012338; Protein flp (FmtA-like protein) flp SA2230 Staphylococcus aureus (strain N315) TR28902_c0_g4_i1 P86789 GIGA6_CRAGI 6.00E-07 GO:0016021 integral to membrane IPR001466; IPR012338; Gigasin-6 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) TR28906_c1_g1_i1 Q7Z5N4 SDK1_HUMAN 2.00E-23 GO:0007155; GO:0016021 cell adhesion; integral to membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Protein sidekick-1 SDK1 Homo sapiens (Human) TR28910_c1_g1_i2 P82596 PLC_HALLA 2.00E-19 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR28910_c2_g3_i1 Q9Y6R7 FCGBP_HUMAN 1.00E-17 GO:0005737; GO:0005576 cytoplasm; extracellular region IPR003645; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) TR28911_c0_g1_i1 Q7JQD3 GELS1_LUMTE 1.00E-91 GO:0003779; GO:0051693; GO:0030043; GO:0030041; GO:0051014; GO:0045010; GO:0005509; GO:0005737; GO:0005856; GO:0007275 actin binding; actin filament capping; actin filament fragmentation; actin filament polymerization; actin filament severing; actin nucleation; calcium ion binding; cytoplasm; cytoskeleton; multicellular organismal development IPR007123; IPR007122; Gelsolin-like protein 1 (Actin-modulator) (EWAM) (EWAM-P1) AM Lumbricus terrestris (Common earthworm) TR28911_c0_g2_i1 Q29297 ADSV_PIG 3.00E-09 GO:0051693; GO:0032330 actin filament capping; regulation of chondrocyte differentiation IPR007123; IPR007122; Adseverin (Scinderin) (Fragment) SCIN Sus scrofa (Pig) TR28912_c0_g1_i1 P41696 AZF1_YEAST 9.00E-09 GO:0000978; GO:0001077; GO:0071322; GO:0005829; GO:0046872; GO:0005634; GO:0060237 RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; cellular response to carbohydrate stimulus; cytosol; metal ion binding; nucleus; regulation of fungal-type cell wall organization IPR007087; IPR015880; IPR013087; Asparagine-rich zinc finger protein AZF1 AZF1 YOR113W O3244 YOR3244W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR28912_c2_g1_i1 Q6ZN19 ZN841_HUMAN 2.00E-27 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 841 ZNF841 Homo sapiens (Human) TR28912_c2_g1_i2 A2T812 ZN287_PONPY 2.00E-24 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein 287 ZNF287 Pongo pygmaeus (Bornean orangutan) TR28914_c3_g1_i1 Q7ZUV1 PKHF2_DANRE 2.00E-103 GO:0031901; GO:0005783; GO:0046872; GO:0005543; GO:0015031 early endosome membrane; endoplasmic reticulum; metal ion binding; phospholipid binding; protein transport IPR011993; IPR001849; IPR000306; IPR017455; IPR011011; IPR013083; Pleckstrin homology domain-containing family F member 2 (PH domain-containing family F member 2) plekhf2 zgc:56073 Danio rerio (Zebrafish) (Brachydanio rerio) TR28914_c3_g1_i3 Q7Z3T8 ZFY16_HUMAN 7.00E-13 GO:0005545; GO:0030509; GO:0031901; GO:0016197; GO:0046872; GO:0005547; GO:0006622; GO:0008565; GO:0030100; GO:0016050 O60784 "1-phosphatidylinositol binding; BMP signaling pathway; early endosome membrane; endosomal transport; metal ion binding; phosphatidylinositol-3,4,5-trisphosphate binding; protein targeting to lysosome; protein transporter activity; regulation of endocytosis; vesicle organization" IPR022557; IPR000306; IPR017455; IPR011011; IPR017165; IPR013083; Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) ZFYVE16 KIAA0305 Homo sapiens (Human) TR28915_c0_g1_i1 Q5HZG4 TAF3_MOUSE 3.00E-12 GO:0051457; GO:0043433; GO:0000122; GO:0005669; GO:0006366; GO:0008270 Q6SJ95 maintenance of protein location in nucleus; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; transcription factor TFIID complex; transcription from RNA polymerase II promoter; zinc ion binding IPR006565; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140) Taf3 Mus musculus (Mouse) TR28915_c0_g1_i2 Q28J24 TAF8_XENTR 1.00E-67 GO:0030154; GO:0005737; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "cell differentiation; cytoplasm; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006565; IPR009072; IPR019473; Transcription initiation factor TFIID subunit 8 (TBP-associated factor 8) taf8 TNeu125i04.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28916_c0_g1_i2 Q6Y1H2 HACD2_HUMAN 1.00E-75 GO:0005789; GO:0006633; GO:0016021; GO:0016829 P51572 endoplasmic reticulum membrane; fatty acid biosynthetic process; integral to membrane; lyase activity IPR007482; Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 2) (HACD2) (Protein-tyrosine phosphatase-like member B) PTPLB HACD2 Homo sapiens (Human) TR28916_c0_g1_i4 B0YJ81 HACD1_HUMAN 8.00E-76 GO:0005789; GO:0006633; GO:0016021; GO:0016829; GO:0007275; GO:0004725; GO:0007165 endoplasmic reticulum membrane; fatty acid biosynthetic process; integral to membrane; lyase activity; multicellular organismal development; protein tyrosine phosphatase activity; signal transduction IPR007482; Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 1) (HACD1) (Cementum attachment protein) (Protein-tyrosine phosphatase-like member A) PTPLA HACD1 Homo sapiens (Human) TR28917_c0_g1_i1 Q58DM4 ALKB2_BOVIN 7.00E-86 GO:0006307; GO:0043734; GO:0051747; GO:0008198; GO:0005634; GO:0035511 DNA dealkylation involved in DNA repair; DNA-N1-methyladenine dioxygenase activity; cytosine C-5 DNA demethylase activity; ferrous iron binding; nucleus; oxidative DNA demethylation IPR027450; IPR005123; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 (EC 1.14.11.33) (Alkylated DNA repair protein alkB homolog 2) (DNA oxidative demethylase ALKBH2) ALKBH2 ABH2 Bos taurus (Bovine) TR28922_c0_g2_i1 Q5ZKL6 MBOA2_CHICK 3.00E-48 GO:0016021; GO:0008654; GO:0016746 "integral to membrane; phospholipid biosynthetic process; transferase activity, transferring acyl groups" IPR004299; Lipid metabolism; phospholipid metabolism. Membrane-bound O-acyltransferase domain-containing protein 2 (O-acyltransferase domain-containing protein 2) (EC 2.3.-.-) mboat2 oact2 RCJMB04_10b24 Gallus gallus (Chicken) TR28924_c3_g1_i1 Q15075 EEA1_HUMAN 9.00E-54 GO:0005545; GO:0030742; GO:0005516; GO:0005829; GO:0005769; GO:0031901; GO:0045022; GO:0019897; GO:0042803; GO:0055037; GO:0005969; GO:0016189; GO:0006906; GO:0008270 P04626; Q9UL26; P20339; P61020; Q63635 1-phosphatidylinositol binding; GTP-dependent protein binding; calmodulin binding; cytosol; early endosome; early endosome membrane; early endosome to late endosome transport; extrinsic to plasma membrane; protein homodimerization activity; recycling endosome; serine-pyruvate aminotransferase complex; synaptic vesicle to endosome fusion; vesicle fusion; zinc ion binding IPR007087; IPR015880; IPR000306; IPR017455; IPR011011; IPR013083; Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) EEA1 ZFYVE2 Homo sapiens (Human) TR28926_c0_g1_i1 A0JMU5 ANM10_XENLA 4.00E-11 GO:0005737; GO:0008276 cytoplasm; protein methyltransferase activity IPR025799; IPR010456; IPR013026; IPR011990; IPR019734; Putative protein arginine N-methyltransferase 10 (EC 2.1.1.-) prmt10 Xenopus laevis (African clawed frog) TR28926_c0_g1_i3 Q6NWG4 ANM6_DANRE 5.00E-99 GO:0006281; GO:0042393; GO:0070612; GO:0070611; GO:0044020; GO:0045892; GO:0005634; GO:0035242; GO:0035241; GO:0006351 "DNA repair; histone binding; histone methyltransferase activity (H2A-R3 specific); histone methyltransferase activity (H3-R2 specific); histone methyltransferase activity (H4-R3 specific); negative regulation of transcription, DNA-dependent; nucleus; protein-arginine omega-N asymmetric methyltransferase activity; protein-arginine omega-N monomethyltransferase activity; transcription, DNA-dependent" IPR025799; IPR026132; Protein arginine N-methyltransferase 6 (EC 2.1.1.-) (Histone-arginine N-methyltransferase PRMT6) (EC 2.1.1.125) prmt6 Danio rerio (Zebrafish) (Brachydanio rerio) TR28926_c0_g1_i4 B0JYW5 ANM6_XENTR 1.00E-107 GO:0006281; GO:0042393; GO:0070612; GO:0070611; GO:0044020; GO:0045892; GO:0005634; GO:0035242; GO:0035241; GO:0006351 "DNA repair; histone binding; histone methyltransferase activity (H2A-R3 specific); histone methyltransferase activity (H3-R2 specific); histone methyltransferase activity (H4-R3 specific); negative regulation of transcription, DNA-dependent; nucleus; protein-arginine omega-N asymmetric methyltransferase activity; protein-arginine omega-N monomethyltransferase activity; transcription, DNA-dependent" IPR025799; IPR026132; Protein arginine N-methyltransferase 6 (EC 2.1.1.-) (Histone-arginine N-methyltransferase PRMT6) (EC 2.1.1.125) prmt6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28926_c0_g1_i5 Q7Q2B7 CARM1_ANOGA 2.00E-38 GO:0006338; GO:0005737; GO:0034969; GO:0042054; GO:0008469; GO:0005634; GO:0035242; GO:0035241; GO:0006355; GO:0006351 "chromatin remodeling; cytoplasm; histone arginine methylation; histone methyltransferase activity; histone-arginine N-methyltransferase activity; nucleus; protein-arginine omega-N asymmetric methyltransferase activity; protein-arginine omega-N monomethyltransferase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025799; IPR025797; Histone-arginine methyltransferase CARMER (EC 2.1.1.-) (EC 2.1.1.125) (Coactivator-associated arginine methyltransferase 1) (AgCARM1) CARM1 AGAP003923 Anopheles gambiae (African malaria mosquito) TR28926_c0_g1_i6 Q6P2P2 ANM10_HUMAN 3.00E-13 GO:0005737; GO:0008276 cytoplasm; protein methyltransferase activity IPR025799; IPR010456; IPR013026; IPR011990; IPR013105; IPR019734; Putative protein arginine N-methyltransferase 10 (EC 2.1.1.-) PRMT10 Homo sapiens (Human) TR28931_c1_g1_i1 O54902 NRAM2_RAT 0 GO:0045177; GO:0046870; GO:0015086; GO:0071456; GO:0071281; GO:0071356; GO:0050897; GO:0015087; GO:0005507; GO:0005375; GO:0015093; GO:0016021; GO:0005506; GO:0055072; GO:0031902; GO:0015094; GO:0005765; GO:0030145; GO:0005384; GO:0016151; GO:0015099; GO:0046686; GO:0010288; GO:0010042; GO:0008270 apical part of cell; cadmium ion binding; cadmium ion transmembrane transporter activity; cellular response to hypoxia; cellular response to iron ion; cellular response to tumor necrosis factor; cobalt ion binding; cobalt ion transmembrane transporter activity; copper ion binding; copper ion transmembrane transporter activity; ferrous iron transmembrane transporter activity; integral to membrane; iron ion binding; iron ion homeostasis; late endosome membrane; lead ion transmembrane transporter activity; lysosomal membrane; manganese ion binding; manganese ion transmembrane transporter activity; nickel cation binding; nickel cation transmembrane transporter activity; response to cadmium ion; response to lead ion; response to manganese ion; zinc ion binding IPR001046; Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1) (Solute carrier family 11 member 2) Slc11a2 Dct1 Dmt1 Nramp2 Rattus norvegicus (Rat) TR28935_c0_g1_i1 P91753 MP62_LYTPI 5.00E-23 GO:0051301; GO:0007067; GO:0003676; GO:0005634 cell division; mitosis; nucleic acid binding; nucleus IPR004301; IPR024057; Mitotic apparatus protein p62 Lytechinus pictus (Painted sea urchin) TR28935_c0_g1_i2 P91753 MP62_LYTPI 4.00E-23 GO:0051301; GO:0007067; GO:0003676; GO:0005634 cell division; mitosis; nucleic acid binding; nucleus IPR004301; IPR024057; Mitotic apparatus protein p62 Lytechinus pictus (Painted sea urchin) TR28939_c7_g1_i3 Q196Y9 VF259_IIV3 1.00E-20 Uncharacterized protein 071L IIV3-071L Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus) TR28940_c0_g1_i1 Q9YH58 FTCD_CHICK 6.00E-48 GO:0005794; GO:0005814; GO:0005542; GO:0030412; GO:0030409; GO:0019556; GO:0019557; GO:0035999 Golgi apparatus; centriole; folic acid binding; formimidoyltetrahydrofolate cyclodeaminase activity; glutamate formimidoyltransferase activity; histidine catabolic process to glutamate and formamide; histidine catabolic process to glutamate and formate; tetrahydrofolate interconversion IPR007044; IPR013802; IPR004227; IPR012886; IPR022384; Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1. One-carbon metabolism; tetrahydrofolate interconversion. Formimidoyltransferase-cyclodeaminase (Formiminotransferase-cyclodeaminase) (FTCD) (p60) [Includes: Glutamate formimidoyltransferase (EC 2.1.2.5) (Glutamate formiminotransferase) (Glutamate formyltransferase); Formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) (Formiminotetrahydrofolate cyclodeaminase)] FTCD Gallus gallus (Chicken) TR28941_c0_g1_i1 Q5U3V9 SNF8_DANRE 6.00E-114 GO:0005737; GO:0015031 cytoplasm; protein transport IPR007286; IPR016689; IPR011991; Vacuolar-sorting protein SNF8 (ESCRT-II complex subunit VPS22) snf8 si:dkey-220f10.1 zgc:101578 Danio rerio (Zebrafish) (Brachydanio rerio) TR28942_c0_g1_i2 Q9CQ46 EFCB2_MOUSE 6.00E-74 GO:0005509 calcium ion binding IPR011992; IPR002048; EF-hand calcium-binding domain-containing protein 2 Efcab2 Mus musculus (Mouse) TR28943_c0_g1_i2 Q17ED3 U466_AEDAE 6.00E-06 GO:0016021; GO:0005739 integral to membrane; mitochondrion IPR018782; "Protein SMDT1 homolog, mitochondrial" AAEL003858 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR28944_c0_g1_i1 Q8BWF2 GIMA5_MOUSE 1.00E-36 GO:0005525; GO:0016021; GO:0005764; GO:0005741 GTP binding; integral to membrane; lysosome; mitochondrial outer membrane IPR006703; IPR027417; GTPase IMAP family member 5 (Immunity-associated nucleotide 4-like 1 protein) (Immunity-associated protein 3) Gimap5 Ian4l1 Imap3 Mus musculus (Mouse) TR28944_c0_g1_i2 Q5FVN6 GIMA6_RAT 1.00E-29 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 6 (Immunity-associated nucleotide 6 protein) (IAN-6) Gimap6 Ian6 Rattus norvegicus (Rat) TR28944_c0_g2_i1 Q8NHV1 GIMA7_HUMAN 2.00E-43 GO:0005525; GO:0003924; GO:0005811 GTP binding; GTPase activity; lipid particle IPR006703; IPR027417; GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) TR28945_c0_g1_i1 P05934 CALM_STRPU 5.00E-28 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) (Fragment) Strongylocentrotus purpuratus (Purple sea urchin) TR28945_c0_g1_i2 P02594 CALM_ELEEL 3.00E-71 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) calm Electrophorus electricus (Electric eel) TR28947_c0_g1_i1 Q9H1A3 METL9_HUMAN 1.00E-90 IPR007884; Methyltransferase-like protein 9 (DORA reverse strand protein) (DREV) (DREV1) METTL9 DREV CGI-81 Homo sapiens (Human) TR28948_c1_g3_i1 O93852 ALO_CANAL 5.00E-11 GO:0003885; GO:0008762; GO:0009058; GO:0034599; GO:0009267; GO:0036170; GO:0050660; GO:0031966; GO:0005739; GO:0009405; GO:0005886; GO:0006767 "D-arabinono-1,4-lactone oxidase activity; UDP-N-acetylmuramate dehydrogenase activity; biosynthetic process; cellular response to oxidative stress; cellular response to starvation; filamentous growth of a population of unicellular organisms in response to starvation; flavin adenine dinucleotide binding; mitochondrial membrane; mitochondrion; pathogenesis; plasma membrane; water-soluble vitamin metabolic process" IPR007173; IPR016169; IPR016166; IPR016167; IPR010031; IPR023595; IPR006094; IPR006093; "Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2." "D-arabinono-1,4-lactone oxidase (ALO) (EC 1.1.3.37) (L-galactono-gamma-lactone oxidase)" ALO1 ALO CaO19.7551 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) TR28950_c0_g1_i1 Q6KAS7 ZN521_MOUSE 3.00E-09 GO:0003677; GO:0030154; GO:0046872; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cell differentiation; metal ion binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 521 (Ecotropic viral integration site 3 protein) Znf521 Evi3 Zfp521 Mus musculus (Mouse) TR28950_c2_g1_i1 Q02975 Z354A_RAT 1.00E-13 GO:0003677; GO:0001822; GO:0046872; GO:0000122; GO:0007576; GO:0005730; GO:0051593; GO:0001666; GO:0003700; GO:0006351 "DNA binding; kidney development; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleolar fragmentation; nucleolus; response to folic acid; response to hypoxia; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; "Zinc finger protein 354A (Kidney, ischemia, and developmentally-regulated protein 1) (Renal transcription factor Kid-1) (Transcription factor 17) (TCF-17)" Znf354a Kid1 Tcf17 Zfp354a Rattus norvegicus (Rat) TR28950_c2_g2_i1 A6QNZ0 ZN187_BOVIN 4.00E-13 GO:0046872; GO:0003676; GO:0005634; GO:0003700; GO:0006351 "metal ion binding; nucleic acid binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 26 (Zinc finger protein 187) ZSCAN26 ZNF187 Bos taurus (Bovine) TR28950_c4_g1_i1 Q8CDC7 ZBTB9_MOUSE 4.00E-06 GO:0003677; GO:0046872; GO:0005739; GO:0005730; GO:0006355; GO:0006351 "DNA binding; metal ion binding; mitochondrion; nucleolus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 9 Zbtb9 Mus musculus (Mouse) TR28950_c7_g1_i1 P52738 ZN140_HUMAN 7.00E-09 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 140 ZNF140 Homo sapiens (Human) TR28951_c0_g1_i1 Q3ZCJ2 AK1A1_BOVIN 9.00E-35 GO:0008106 alcohol dehydrogenase (NADP+) activity IPR001395; IPR018170; IPR020471; IPR023210; Alcohol dehydrogenase [NADP(+)] (EC 1.1.1.2) (Aldehyde reductase) (Aldo-keto reductase family 1 member A1) AKR1A1 Bos taurus (Bovine) TR28951_c0_g1_i2 Q96JD6 AKCL2_HUMAN 1.00E-23 GO:0050571; GO:0005737 "1,5-anhydro-D-fructose reductase activity; cytoplasm" IPR001395; IPR018170; IPR020471; IPR023210; "1,5-anhydro-D-fructose reductase (AF reductase) (EC 1.1.1.263) (Aldo-keto reductase family 1 member C-like protein 2) (Aldo-keto reductase family 1 member E2) (LoopADR) (Testis-specific protein) (hTSP)" AKR1E2 AKR1CL2 AKRDC1 Homo sapiens (Human) TR28956_c2_g2_i1 Q700K0 SSPO_RAT 1.00E-15 GO:0007155; GO:0005615 cell adhesion; extracellular space IPR000421; IPR006207; IPR008979; IPR023415; IPR002172; IPR000884; IPR002919; IPR014853; IPR006552; IPR001007; IPR001846; SCO-spondin Sspo Rattus norvegicus (Rat) TR28956_c5_g1_i1 Q13591 SEM5A_HUMAN 1.00E-14 GO:0007411; GO:0008046; GO:0007155; GO:0007267; GO:0016021; GO:0001569; GO:0005886 axon guidance; axon guidance receptor activity; cell adhesion; cell-cell signaling; integral to membrane; patterning of blood vessels; plasma membrane IPR016201; IPR002165; IPR001627; IPR027231; IPR000884; IPR015943; Semaphorin-5A (Semaphorin-F) (Sema F) SEMA5A SEMAF Homo sapiens (Human) TR28957_c1_g1_i1 O59922 KAPR_EMENI 7.00E-11 GO:0030552; GO:0005952; GO:0008603 cAMP binding; cAMP-dependent protein kinase complex; cAMP-dependent protein kinase regulator activity IPR002373; IPR012198; IPR018490; IPR018488; IPR000595; IPR014710; cAMP-dependent protein kinase regulatory subunit (PKA regulatory subunit) pkaR AN4987 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR28960_c0_g1_i1 Q96C34 RUND1_HUMAN 9.00E-39 IPR004012; RUN domain-containing protein 1 RUNDC1 LP5161 Homo sapiens (Human) TR28960_c1_g2_i1 Q96C34 RUND1_HUMAN 4.00E-25 IPR004012; RUN domain-containing protein 1 RUNDC1 LP5161 Homo sapiens (Human) TR28961_c1_g1_i1 P15153 RAC2_HUMAN 3.00E-98 GO:0005525; GO:0003924; GO:0030036; GO:0007411; GO:0045453; GO:0030031; GO:0005829; GO:0005635; GO:0005886; GO:0030168; GO:0008284; GO:0010310; GO:0060263; GO:0051056; GO:0007264 GTP binding; GTPase activity; actin cytoskeleton organization; axon guidance; bone resorption; cell projection assembly; cytosol; nuclear envelope; plasma membrane; platelet activation; positive regulation of cell proliferation; regulation of hydrogen peroxide metabolic process; regulation of respiratory burst; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2) RAC2 Homo sapiens (Human) TR28961_c1_g1_i2 P53936 YNI9_YEAST 1.00E-08 Putative uncharacterized protein YNL089C YNL089C N2242 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR28964_c0_g1_i1 Q8LCY2 ISAM2_ARATH 6.00E-30 GO:0016226; GO:0051536; GO:0046872; GO:0005739; GO:0005198 iron-sulfur cluster assembly; iron-sulfur cluster binding; metal ion binding; mitochondrion; structural molecule activity IPR000361; IPR016092; "Iron-sulfur assembly protein IscA-like 2, mitochondrial" At5g03905 F8F6_110 MED24.21 Arabidopsis thaliana (Mouse-ear cress) TR28964_c0_g1_i2 Q86U28 ISCA2_HUMAN 9.00E-37 GO:0016226; GO:0051536; GO:0046872; GO:0005739; GO:0005198 iron-sulfur cluster assembly; iron-sulfur cluster binding; metal ion binding; mitochondrion; structural molecule activity IPR000361; IPR016092; IPR017870; "Iron-sulfur cluster assembly 2 homolog, mitochondrial (HESB-like domain-containing protein 1)" ISCA2 HBLD1 Homo sapiens (Human) TR28966_c0_g1_i2 O35129 PHB2_MOUSE 2.00E-136 GO:0060749; GO:0060744; GO:0005743; GO:0033147; GO:0033600; GO:0045892; GO:0005634; GO:0060762; GO:0006351 "mammary gland alveolus development; mammary gland branching involved in thelarche; mitochondrial inner membrane; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of mammary gland epithelial cell proliferation; negative regulation of transcription, DNA-dependent; nucleus; regulation of branching involved in mammary gland duct morphogenesis; transcription, DNA-dependent" IPR001107; IPR000163; Prohibitin-2 (B-cell receptor-associated protein BAP37) (Repressor of estrogen receptor activity) Phb2 Bap Bcap37 Rea Mus musculus (Mouse) TR28968_c3_g1_i1 P62810 EXPI_MOUSE 2.00E-09 GO:0005576; GO:0030414 extracellular region; peptidase inhibitor activity IPR008197; WAP four-disulfide core domain protein 18 (Extracellular peptidase inhibitor) (Protein WDNM1) Wfdc18 Expi Wdnm1 Mus musculus (Mouse) TR28968_c3_g2_i1 P14730 EXPI_RAT 3.00E-10 GO:0005576; GO:0030414 extracellular region; peptidase inhibitor activity IPR008197; WAP four-disulfide core domain protein 18 (Extracellular peptidase inhibitor) (Protein WDNM1) (Fragment) Wfdc18 Expi Wdnm1 Rattus norvegicus (Rat) TR28969_c0_g1_i1 Q9YHZ6 CDC45_XENLA 2.00E-47 GO:0006270; GO:0007049; GO:0003682; GO:0005654 DNA replication initiation; cell cycle; chromatin binding; nucleoplasm IPR003874; Cell division control protein 45 homolog cdc45 cdc45l Xenopus laevis (African clawed frog) TR28974_c7_g1_i2 Q8TEQ6 GEMI5_HUMAN 4.00E-48 GO:0097504; GO:0005829; GO:0034660; GO:0016604; GO:0006461; GO:0017069; GO:0005681; GO:0000387 P06730; Q16637; P62304 Gemini of coiled bodies; cytosol; ncRNA metabolic process; nuclear body; protein complex assembly; snRNA binding; spliceosomal complex; spliceosomal snRNP assembly IPR020472; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; Gem-associated protein 5 (Gemin5) GEMIN5 Homo sapiens (Human) TR28974_c7_g1_i3 Q8BX17 GEMI5_MOUSE 1.00E-20 GO:0008380; GO:0005737; GO:0006397; GO:0017069; GO:0005681 RNA splicing; cytoplasm; mRNA processing; snRNA binding; spliceosomal complex IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Gem-associated protein 5 (Gemin5) Gemin5 Mus musculus (Mouse) TR28975_c2_g1_i1 Q0IIF6 FAIM1_BOVIN 6.00E-69 GO:0006915; GO:0005737; GO:0043066 apoptotic process; cytoplasm; negative regulation of apoptotic process IPR010695; Fas apoptotic inhibitory molecule 1 FAIM Bos taurus (Bovine) TR28976_c0_g2_i1 P54357 MLC2_DROME 2.00E-36 GO:0030048; GO:0005509; GO:0016460; GO:0031475; GO:0031476; GO:0031477 actin filament-based movement; calcium ion binding; myosin II complex; myosin V complex; myosin VI complex; myosin VII complex IPR011992; IPR018247; IPR002048; Myosin-2 essential light chain (Myosin II essential light chain) (Non-muscle myosin essential light chain) Mlc-c CG3201 Drosophila melanogaster (Fruit fly) TR28976_c0_g3_i1 Q03509 CALM6_ARATH 3.00E-15 GO:0005509; GO:0019722 Q2V359; Q8LG64; Q42479; Q9SND6; P55737; D3K0M2; Q9FHN8; Q9SUP6 calcium ion binding; calcium-mediated signaling IPR011992; IPR018247; IPR002048; Calmodulin-6 (CaM-6) CAM6 At5g21274 F13M11.? Arabidopsis thaliana (Mouse-ear cress) TR28979_c1_g1_i1 Q5R454 AR6P1_PONAB 1.00E-38 GO:0005784; GO:0006613; GO:0005829; GO:0016021 Sec61 translocon complex; cotranslational protein targeting to membrane; cytosol; integral to membrane IPR003388; ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6-interacting protein 1) (Aip-1) (Protein TBX2) ARL6IP1 ARL6IP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR28979_c1_g1_i2 Q15041 AR6P1_HUMAN 1.00E-37 GO:0005784; GO:0006613; GO:0005829; GO:0005783; GO:0016021 P51116 Sec61 translocon complex; cotranslational protein targeting to membrane; cytosol; endoplasmic reticulum; integral to membrane IPR003388; ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6-interacting protein 1) (Aip-1) ARL6IP1 ARL6IP KIAA0069 Homo sapiens (Human) TR28980_c1_g1_i1 Q9SSM2 MDLL_ARATH 4.00E-07 GO:0006066; GO:0008812; GO:0050660; GO:0046593 alcohol metabolic process; choline dehydrogenase activity; flavin adenine dinucleotide binding; mandelonitrile lyase activity IPR012132; IPR000172; IPR007867; (R)-mandelonitrile lyase-like (EC 4.1.2.10) (Hydroxynitrile lyase-like) ((R)-oxynitrilase-like) At1g73050 F3N23.25 Arabidopsis thaliana (Mouse-ear cress) TR28980_c1_g1_i2 Q9S746 HTH_ARATH 1.00E-06 GO:0006066; GO:0007267; GO:0008812; GO:0009553; GO:0005576; GO:0010430; GO:0050660; GO:0046593 alcohol metabolic process; cell-cell signaling; choline dehydrogenase activity; embryo sac development; extracellular region; fatty acid omega-oxidation; flavin adenine dinucleotide binding; mandelonitrile lyase activity IPR012132; IPR000172; IPR007867; Protein HOTHEAD (Protein ADHESION OF CALYX EDGES) HTH ACE At1g72970 F3N23.17 Arabidopsis thaliana (Mouse-ear cress) TR28980_c2_g1_i1 P18173 DHGL_DROME 1.00E-32 GO:0006066; GO:0008812; GO:0005576; GO:0050660; GO:0004344; GO:0006006; GO:0008364; GO:0046693 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding; glucose dehydrogenase activity; glucose metabolic process; pupal chitin-based cuticle development; sperm storage IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld CG1152 Drosophila melanogaster (Fruit fly) TR28983_c3_g1_i3 Q28DB0 TT39B_XENTR 6.00E-56 IPR019412; IPR011990; IPR001440; Tetratricopeptide repeat protein 39B (TPR repeat protein 39B) ttc39b TEgg088o02.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR28986_c0_g1_i1 A0JMD2 LST2_DANRE 2.00E-77 GO:0005829; GO:0031901; GO:0046872; GO:0007175; GO:0032266 cytosol; early endosome membrane; metal ion binding; negative regulation of epidermal growth factor-activated receptor activity; phosphatidylinositol-3-phosphate binding IPR000306; IPR017455; IPR011011; IPR013083; Lateral signaling target protein 2 homolog (Zinc finger FYVE domain-containing protein 28) zfyve28 lst2 zgc:152894 Danio rerio (Zebrafish) (Brachydanio rerio) TR28986_c1_g1_i1 O13821 VPS27_SCHPO 2.00E-16 GO:0033565; GO:0031321; GO:0005829; GO:0006897; GO:0010008; GO:0006900; GO:0046872; GO:0005634; GO:0032266; GO:0005628; GO:0045053; GO:0043328; GO:0043130 ESCRT-0 complex; ascospore-type prospore assembly; cytosol; endocytosis; endosome membrane; membrane budding; metal ion binding; nucleus; phosphatidylinositol-3-phosphate binding; prospore membrane; protein retention in Golgi apparatus; protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ubiquitin binding IPR008942; IPR017073; IPR003903; IPR002014; IPR018205; IPR027427; IPR000306; IPR017455; IPR011011; IPR013083; Vacuolar protein sorting-associated protein 27 (Suppressor of ste12 deletion protein 4) sst4 vps27 SPAC19A8.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR28988_c2_g2_i1 Q7Z494 NPHP3_HUMAN 1.00E-120 GO:0016055; GO:0003283; GO:0060271; GO:0060027; GO:0071908; GO:0071910; GO:0035469; GO:0071909; GO:0060287; GO:0007163; GO:0030198; GO:0001947; GO:0060993; GO:0006629; GO:0030324; GO:0048496; GO:0090090; GO:0045494; GO:0072372; GO:0030814; GO:2000167; GO:0072189 Q9UPV0 Wnt receptor signaling pathway; atrial septum development; cilium morphogenesis; convergent extension involved in gastrulation; determination of intestine left/right asymmetry; determination of liver left/right asymmetry; determination of pancreatic left/right asymmetry; determination of stomach left/right asymmetry; epithelial cilium movement involved in determination of left/right asymmetry; establishment or maintenance of cell polarity; extracellular matrix organization; heart looping; kidney morphogenesis; lipid metabolic process; lung development; maintenance of organ identity; negative regulation of canonical Wnt receptor signaling pathway; photoreceptor cell maintenance; primary cilium; regulation of cAMP metabolic process; regulation of planar cell polarity pathway involved in neural tube closure; ureter development IPR027417; IPR013026; IPR011990; IPR019734; Nephrocystin-3 NPHP3 KIAA2000 Homo sapiens (Human) TR28991_c0_g1_i1 Q6P6S0 SNP47_RAT 2.00E-31 GO:0031083; GO:0012505; GO:0016020; GO:0048471 BLOC-1 complex; endomembrane system; membrane; perinuclear region of cytoplasm IPR000727; Synaptosomal-associated protein 47 (SNAP-47) (Synaptosomal-associated 47 kDa protein) Snap47 Rattus norvegicus (Rat) TR28993_c0_g1_i1 Q18785 MIF2_CAEEL 1.00E-13 IPR001398; IPR019829; IPR014347; MIF-like protein mif-2 mif-2 C52E4.2 Caenorhabditis elegans TR28993_c0_g1_i2 Q640C5 DOPDB_XENLA 2.00E-09 GO:0033981; GO:0005737; GO:0042438 D-dopachrome decarboxylase activity; cytoplasm; melanin biosynthetic process IPR001398; IPR014347; D-dopachrome decarboxylase-B (EC 4.1.1.84) (D-dopachrome tautomerase-B) ddt-b Xenopus laevis (African clawed frog) TR28993_c0_g1_i3 P90835 MIF3_CAEEL 4.00E-08 GO:0005634; GO:0010883; GO:0090087 nucleus; regulation of lipid storage; regulation of peptide transport IPR001398; IPR019829; IPR014347; MIF-like protein mif-3 mif-3 F13G3.9 Caenorhabditis elegans TR28994_c0_g1_i1 Q8VC42 MIC1_MOUSE 7.00E-35 IPR009755; IPR017986; Uncharacterized protein C18orf8 homolog (Colon cancer-associated protein Mic1) (Mic-1) Mic1 Mus musculus (Mouse) TR28994_c0_g2_i1 Q8VC42 MIC1_MOUSE 0 IPR009755; IPR017986; Uncharacterized protein C18orf8 homolog (Colon cancer-associated protein Mic1) (Mic-1) Mic1 Mus musculus (Mouse) TR28994_c0_g2_i2 Q96DM3 MIC1_HUMAN 0 GO:0005765 lysosomal membrane IPR009755; IPR015943; IPR017986; Uncharacterized protein C18orf8 (Colon cancer-associated protein Mic1) (Mic-1) C18orf8 MIC1 Homo sapiens (Human) TR28994_c0_g2_i3 Q54LC7 MIC1_DICDI 2.00E-26 IPR009755; IPR017986; Mic1 domain-containing protein DDB_G0286707 DDB_G0286707 Dictyostelium discoideum (Slime mold) TR28997_c1_g1_i1 O94889 KLH18_HUMAN 1.00E-95 IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 18 KLHL18 KIAA0795 OK/SW-cl.74 Homo sapiens (Human) TR28997_c1_g2_i1 O94889 KLH18_HUMAN 3.00E-157 IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 18 KLHL18 KIAA0795 OK/SW-cl.74 Homo sapiens (Human) TR290_c0_g1_i1 A3R064 DOK3_CHICK 3.00E-12 GO:0005737; GO:0005543; GO:0005886 cytoplasm; phospholipid binding; plasma membrane IPR002404; IPR011993; IPR001849; Docking protein 3 (Downstream of tyrosine kinase 3) DOK3 Gallus gallus (Chicken) TR29000_c0_g1_i1 Q9NUP1 CNO_HUMAN 1.00E-20 GO:0031083; GO:0008089; GO:0048490; GO:0032438; GO:0050885; GO:0031175; GO:0070527; GO:0006892 Q9UL45 BLOC-1 complex; anterograde axon cargo transport; anterograde synaptic vesicle transport; melanosome organization; neuromuscular process controlling balance; neuron projection development; platelet aggregation; post-Golgi vesicle-mediated transport IPR024857; Biogenesis of lysosome-related organelles complex 1 subunit 4 (BLOC-1 subunit 4) (Protein cappuccino homolog) BLOC1S4 CNO Homo sapiens (Human) TR29000_c0_g1_i2 Q8TDM0 BCAS4_HUMAN 5.00E-16 GO:0005737 cytoplasm IPR024857; Breast carcinoma-amplified sequence 4 BCAS4 Homo sapiens (Human) TR29001_c3_g1_i1 Q8N143 BCL6B_HUMAN 2.00E-08 GO:0003677; GO:0046872; GO:0000122; GO:0005634 DNA binding; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; B-cell CLL/lymphoma 6 member B protein (Bcl6-associated zinc finger protein) (Zinc finger protein 62) BCL6B BAZF ZNF62 Homo sapiens (Human) TR29002_c0_g2_i1 Q9ULQ1 TPC1_HUMAN 1.00E-13 GO:0072345; GO:0010008; GO:0016021; GO:0005765; GO:0005244 Itself; Q8NHX9 NAADP-sensitive calcium-release channel activity; endosome membrane; integral to membrane; lysosomal membrane; voltage-gated ion channel activity IPR027359; IPR005821; Two pore calcium channel protein 1 (Voltage-dependent calcium channel protein TPC1) TPCN1 KIAA1169 TPC1 Homo sapiens (Human) TR29002_c3_g1_i1 Q9WTN5 TPC1_RAT 2.00E-102 GO:0072345; GO:0010008; GO:0016021; GO:0005765; GO:0005244 NAADP-sensitive calcium-release channel activity; endosome membrane; integral to membrane; lysosomal membrane; voltage-gated ion channel activity IPR005821; Two pore calcium channel protein 1 (Voltage-dependent calcium channel protein TPC1) Tpcn1 Tpc1 Rattus norvegicus (Rat) TR29004_c0_g1_i1 Q8BFQ6 DIRC2_MOUSE 7.00E-34 GO:0016021; GO:0005765; GO:0006810 integral to membrane; lysosomal membrane; transport IPR016196; Disrupted in renal carcinoma protein 2 homolog Dirc2 Mus musculus (Mouse) TR29007_c0_g1_i1 Q9R0Q8 CLC4E_MOUSE 6.00E-10 GO:0030246; GO:0006955; GO:0016021; GO:0050715; GO:0004872 carbohydrate binding; immune response; integral to membrane; positive regulation of cytokine secretion; receptor activity IPR001304; IPR016186; IPR018378; IPR016187; C-type lectin domain family 4 member E (C-type lectin superfamily member 9) (Macrophage-inducible C-type lectin) Clec4e Clecsf9 Mincle Mus musculus (Mouse) TR29007_c0_g1_i2 P02707 LECH_CHICK 1.00E-13 GO:0030246; GO:0006897; GO:0016021 carbohydrate binding; endocytosis; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; Hepatic lectin Gallus gallus (Chicken) TR29007_c0_g1_i3 Q61830 MRC1_MOUSE 7.00E-06 GO:0009986; GO:0010008; GO:0016021; GO:0005537; GO:0005886; GO:0006898; GO:0004888 cell surface; endosome membrane; integral to membrane; mannose binding; plasma membrane; receptor-mediated endocytosis; transmembrane signaling receptor activity IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; Macrophage mannose receptor 1 (MMR) (CD antigen CD206) Mrc1 Mus musculus (Mouse) TR29007_c0_g1_i5 Q66S03 NATTE_THANI 4.00E-10 GO:0030246; GO:0005576; GO:0006954; GO:0046872 carbohydrate binding; extracellular region; inflammatory response; metal ion binding IPR001304; IPR016186; IPR016187; Galactose-specific lectin nattectin (CTL) Thalassophryne nattereri (Niquim) TR29007_c0_g2_i1 Q66S60 MBL2_GORGO 5.00E-06 GO:0005581; GO:0006958; GO:0001867; GO:0050830; GO:0005615; GO:0051873; GO:0005537; GO:0044130; GO:0050766 "collagen; complement activation, classical pathway; complement activation, lectin pathway; defense response to Gram-positive bacterium; extracellular space; killing by host of symbiont cells; mannose binding; negative regulation of growth of symbiont in host; positive regulation of phagocytosis" IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Mannose-binding protein C (MBP-C) (MBP1) (Mannan-binding protein) (Mannose-binding lectin) MBL2 Gorilla gorilla gorilla (Lowland gorilla) TR29008_c0_g1_i1 Q4V869 ACBD6_XENLA 1.00E-63 GO:0005737; GO:0000062; GO:0008289 cytoplasm; fatty-acyl-CoA binding; lipid binding IPR000582; IPR002110; IPR020683; IPR014352; Acyl-CoA-binding domain-containing protein 6 acbd6 Xenopus laevis (African clawed frog) TR29009_c2_g1_i4 Q03567 YLD2_CAEEL 5.00E-91 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR011701; IPR020846; IPR016196; Uncharacterized transporter C38C10.2 C38C10.2 Caenorhabditis elegans TR29016_c0_g1_i1 P14381 YTX2_XENLA 2.00E-25 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR29016_c0_g1_i2 P11369 POL2_MOUSE 2.00E-15 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR013544; IPR005135; IPR000477; Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element-1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] Pol Gm17492 Mus musculus (Mouse) TR29017_c1_g1_i1 Q7PR68 MED7_ANOGA 4.00E-87 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR009244; Mediator of RNA polymerase II transcription subunit 7 (Mediator complex subunit 7) MED7 AGAP002823 Anopheles gambiae (African malaria mosquito) TR29018_c3_g1_i1 Q54HW1 PSD10_DICDI 2.00E-08 IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) psmD10 DDB_G0289189 Dictyostelium discoideum (Slime mold) TR29018_c3_g1_i2 Q1RK13 Y220_RICBR 2.00E-15 IPR002110; IPR020683; Putative ankyrin repeat protein RBE_0220 RBE_0220 Rickettsia bellii (strain RML369-C) TR29018_c6_g1_i1 Q8VE42 ANR49_MOUSE 5.00E-06 GO:0045893 "positive regulation of transcription, DNA-dependent" IPR002110; IPR020683; Ankyrin repeat domain-containing protein 49 (Fetal globin-increasing factor) (Fetal globin-inducing factor) Ankrd49 Fgif Gbif Mus musculus (Mouse) TR29022_c0_g1_i1 Q6DI40 TTC33_DANRE 7.00E-57 IPR013026; IPR011990; IPR013105; IPR019734; Tetratricopeptide repeat protein 33 (TPR repeat protein 33) ttc33 si:dkey-204l11.4 zgc:86619 Danio rerio (Zebrafish) (Brachydanio rerio) TR29025_c0_g2_i1 Q98943 CASP2_CHICK 3.00E-10 GO:0006915; GO:0004197; GO:0005622; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; intracellular; proteolysis; regulation of apoptotic process IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) TR29027_c4_g1_i1 P20241 NRG_DROME 1.00E-37 GO:0008366; GO:0048675; GO:0005509; GO:0061343; GO:0048036; GO:0048813; GO:0007173; GO:0060857; GO:0008050; GO:0030175; GO:0007560; GO:0016021; GO:0016328; GO:0008049; GO:0035011; GO:0016319; GO:0021682; GO:0007158; GO:0005919; GO:0045924; GO:0035151; GO:0019991; GO:0050808; GO:0005923 "axon ensheathment; axon extension; calcium ion binding; cell adhesion involved in heart morphogenesis; central complex development; dendrite morphogenesis; epidermal growth factor receptor signaling pathway; establishment of glial blood-brain barrier; female courtship behavior; filopodium; imaginal disc morphogenesis; integral to membrane; lateral plasma membrane; male courtship behavior; melanotic encapsulation of foreign target; mushroom body development; nerve maturation; neuron cell-cell adhesion; pleated septate junction; regulation of female receptivity; regulation of tube size, open tracheal system; septate junction assembly; synapse organization; tight junction" IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013151; IPR026966; Neuroglian Nrg CG1634 Drosophila melanogaster (Fruit fly) TR29027_c6_g1_i1 Q13332 PTPRS_HUMAN 3.00E-12 GO:0007155; GO:0021549; GO:0021987; GO:0022038; GO:0030198; GO:0021766; GO:0005887; GO:0021510; GO:0005001 Q16849 cell adhesion; cerebellum development; cerebral cortex development; corpus callosum development; extracellular matrix organization; hippocampus development; integral to plasma membrane; spinal cord development; transmembrane receptor protein tyrosine phosphatase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma) PTPRS Homo sapiens (Human) TR29029_c0_g1_i1 Q8HXW6 PPT1_MACFA 6.00E-132 GO:0005794; GO:0006309; GO:0030424; GO:0051186; GO:0051181; GO:0005829; GO:0005576; GO:0016042; GO:0007042; GO:0005764; GO:0045121; GO:0031579; GO:0030308; GO:0043524; GO:0007399; GO:0005634; GO:0008474; GO:0016290; GO:0048549; GO:0048260; GO:0002084; GO:0015031; GO:0008021 Golgi apparatus; apoptotic DNA fragmentation; axon; cofactor metabolic process; cofactor transport; cytosol; extracellular region; lipid catabolic process; lysosomal lumen acidification; lysosome; membrane raft; membrane raft organization; negative regulation of cell growth; negative regulation of neuron apoptotic process; nervous system development; nucleus; palmitoyl-(protein) hydrolase activity; palmitoyl-CoA hydrolase activity; positive regulation of pinocytosis; positive regulation of receptor-mediated endocytosis; protein depalmitoylation; protein transport; synaptic vesicle IPR002472; Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1) PPT1 QnpA-18851 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR29030_c4_g1_i1 Q6PF15 KLH35_HUMAN 5.00E-13 IPR011705; IPR015916; IPR006652; Kelch-like protein 35 KLHL35 Homo sapiens (Human) TR29030_c4_g2_i1 O28112 Y2170_ARCFU 6.00E-07 IPR015916 Kelch domain-containing protein AF_2170 AF_2170 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) TR29030_c5_g1_i1 O95198 KLHL2_HUMAN 2.00E-28 GO:0031463; GO:0003779; GO:0015629; GO:0005737; GO:0005829; GO:0030027; GO:0016567; GO:0001726 Cul3-RING ubiquitin ligase complex; actin binding; actin cytoskeleton; cytoplasm; cytosol; lamellipodium; protein ubiquitination; ruffle IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 2 (Actin-binding protein Mayven) KLHL2 Homo sapiens (Human) TR29030_c5_g1_i2 Q6V595 KLHL6_MOUSE 2.00E-36 GO:0050853; GO:0002467 B cell receptor signaling pathway; germinal center formation IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 6 Klhl6 Mus musculus (Mouse) TR29031_c0_g1_i2 B5RG86 RIHC_SALG2 2.00E-18 GO:0016798; GO:0006144; GO:0006206 "hydrolase activity, acting on glycosyl bonds; purine nucleobase metabolic process; pyrimidine nucleobase metabolic process" IPR023186; IPR001910; IPR022976; Non-specific ribonucleoside hydrolase RihC (EC 3.2.-.-) (Purine/pyrimidine ribonucleoside hydrolase) rihC SG0054 Salmonella gallinarum (strain 287/91 / NCTC 13346) TR29031_c0_g1_i3 B4TPY1 RIHA_SALSV 3.00E-33 GO:0005737; GO:0015949; GO:0006206; GO:0045437 cytoplasm; nucleobase-containing small molecule interconversion; pyrimidine nucleobase metabolic process; uridine nucleosidase activity IPR015910; IPR023186; IPR001910; IPR022975; Pyrimidine-specific ribonucleoside hydrolase RihA (EC 3.2.-.-) (Cytidine/uridine-specific hydrolase) rihA SeSA_A0814 Salmonella schwarzengrund (strain CVM19633) TR29034_c2_g1_i1 P11372 CP2CF_RABIT 7.00E-69 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 2C15 (EC 1.14.14.1) (CYPIIC15) (Cytochrome P450 B32-3) (Fragment) CYP2C15 Oryctolagus cuniculus (Rabbit) TR29034_c2_g1_i2 P00178 CP2B4_RABIT 5.00E-98 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; IPR008068; Cytochrome P450 2B4 (EC 1.14.14.1) (CYPIIB4) (Cytochrome P450 isozyme 2) (Cytochrome P450 LM2) (Cytochrome P450 type B0) (Cytochrome P450 type B1) CYP2B4 Oryctolagus cuniculus (Rabbit) TR29035_c0_g1_i2 Q5BK01 MET24_RAT 7.00E-11 GO:0005576; GO:0008168 extracellular region; methyltransferase activity IPR025714; IPR026913; Methyltransferase-like protein 24 (EC 2.1.1.-) Mettl24 Rattus norvegicus (Rat) TR29036_c4_g1_i2 Q9NQM4 PIHD3_HUMAN 2.00E-24 IPR012981; IPR026697; Protein PIH1D3 (PIH1 domain-containing protein 3) (Sarcoma antigen NY-SAR-97) PIH1D3 CXorf41 Homo sapiens (Human) TR29039_c0_g1_i1 Q96MB7 HARB1_HUMAN 2.00E-15 GO:0005813; GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 centrosome; cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) HARBI1 C11orf77 Homo sapiens (Human) TR29041_c0_g1_i1 Q4KMC9 CA198_DANRE 3.00E-17 Uncharacterized protein C1orf198 homolog wu:fa18f11 Danio rerio (Zebrafish) (Brachydanio rerio) TR29041_c0_g1_i2 Q58CU6 CA198_BOVIN 6.00E-13 GO:0005737 cytoplasm Uncharacterized protein C1orf198 homolog Bos taurus (Bovine) TR29043_c2_g1_i1 P42679 MATK_HUMAN 5.00E-15 GO:0005524; GO:0008283; GO:0005829; GO:0016020; GO:0007498; GO:0004715; GO:0005634; GO:0008284; GO:0004713 P04626; P08238 ATP binding; cell proliferation; cytosol; membrane; mesoderm development; non-membrane spanning protein tyrosine kinase activity; nucleus; positive regulation of cell proliferation; protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK) MATK CTK HYL Homo sapiens (Human) TR29043_c3_g1_i2 Q0VCH3 CDPF1_BOVIN 1.00E-25 IPR018785; Cysteine-rich DPF motif domain-containing protein 1 CDPF1 Bos taurus (Bovine) TR29043_c4_g1_i1 Q8N490 PNKD_HUMAN 1.00E-92 GO:0006750; GO:0004416; GO:0016020; GO:0005739; GO:0005634; GO:0008270 glutathione biosynthetic process; hydroxyacylglutathione hydrolase activity; membrane; mitochondrion; nucleus; zinc ion binding IPR001279; IPR017782; Probable hydrolase PNKD (EC 3.-.-.-) (Myofibrillogenesis regulator 1) (MR-1) (Paroxysmal nonkinesiogenic dyskinesia protein) (Trans-activated by hepatitis C virus core protein 2) PNKD KIAA1184 MR1 TAHCCP2 FKSG19 UNQ2491/PRO5778 Homo sapiens (Human) TR29043_c6_g1_i1 P50904 RASA1_RAT 9.00E-139 GO:0005099; GO:0030036; GO:0007155; GO:0000910; GO:0005737; GO:0009790; GO:0031235; GO:0046580; GO:0001953; GO:0043524; GO:0005543; GO:0030833; GO:0007165; GO:0001570 Ras GTPase activator activity; actin cytoskeleton organization; cell adhesion; cytokinesis; cytoplasm; embryo development; intrinsic to internal side of plasma membrane; negative regulation of Ras protein signal transduction; negative regulation of cell-matrix adhesion; negative regulation of neuron apoptotic process; phospholipid binding; regulation of actin filament polymerization; signal transduction; vasculogenesis IPR000008; IPR011993; IPR001849; IPR001936; IPR023152; IPR008936; IPR000980; IPR001452; Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP) Rasa1 Rasa Rattus norvegicus (Rat) TR29043_c7_g1_i1 P50904 RASA1_RAT 9.00E-25 GO:0005099; GO:0030036; GO:0007155; GO:0000910; GO:0005737; GO:0009790; GO:0031235; GO:0046580; GO:0001953; GO:0043524; GO:0005543; GO:0030833; GO:0007165; GO:0001570 Ras GTPase activator activity; actin cytoskeleton organization; cell adhesion; cytokinesis; cytoplasm; embryo development; intrinsic to internal side of plasma membrane; negative regulation of Ras protein signal transduction; negative regulation of cell-matrix adhesion; negative regulation of neuron apoptotic process; phospholipid binding; regulation of actin filament polymerization; signal transduction; vasculogenesis IPR000008; IPR011993; IPR001849; IPR001936; IPR023152; IPR008936; IPR000980; IPR001452; Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP) Rasa1 Rasa Rattus norvegicus (Rat) TR29044_c11_g1_i1 A8K0R7 ZN839_HUMAN 1.00E-10 GO:0046872 metal ion binding IPR007087; IPR015880; Zinc finger protein 839 (Renal carcinoma antigen NY-REN-50) ZNF839 C14orf131 Homo sapiens (Human) TR29045_c2_g1_i1 Q8BR76 MKS3_MOUSE 5.00E-34 GO:0036038; GO:0048754; GO:0042384; GO:0030659; GO:0005789; GO:0016021; GO:0005932; GO:0010826; GO:0005886 TCTN-B9D complex; branching morphogenesis of an epithelial tube; cilium assembly; cytoplasmic vesicle membrane; endoplasmic reticulum membrane; integral to membrane; microtubule basal body; negative regulation of centrosome duplication; plasma membrane IPR009030; IPR019170; Meckelin (Meckel syndrome type 3 protein homolog) (Transmembrane protein 67) Tmem67 Mks3 Mus musculus (Mouse) TR29045_c3_g1_i2 Q5HYA8 MKS3_HUMAN 9.00E-158 GO:0030433; GO:0036038; GO:0005813; GO:0042384; GO:0060170; GO:0030659; GO:0005789; GO:0016021; GO:0005932; GO:0010826 ER-associated protein catabolic process; TCTN-B9D complex; centrosome; cilium assembly; cilium membrane; cytoplasmic vesicle membrane; endoplasmic reticulum membrane; integral to membrane; microtubule basal body; negative regulation of centrosome duplication IPR009030; IPR019170; Meckelin (Meckel syndrome type 3 protein) (Transmembrane protein 67) TMEM67 MKS3 Homo sapiens (Human) TR29050_c6_g1_i1 Q9MYM7 B3GT1_PONPY 2.00E-18 GO:0000139; GO:0008378; GO:0016021; GO:0006486 Golgi membrane; galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) TR29054_c0_g1_i1 Q3V2K1 CX065_MOUSE 1.00E-09 Uncharacterized protein CXorf65 homolog Gm614 Mus musculus (Mouse) TR29056_c0_g1_i1 Q66H96 CABP7_RAT 1.00E-18 GO:0005794; GO:0005509; GO:0016021; GO:0048471; GO:0005886; GO:0032588 Golgi apparatus; calcium ion binding; integral to membrane; perinuclear region of cytoplasm; plasma membrane; trans-Golgi network membrane IPR011992; IPR018247; IPR002048; IPR001751; Calcium-binding protein 7 (CaBP7) (Calneuron II) (Calneuron-2) Cabp7 Caln2 Rattus norvegicus (Rat) TR29056_c0_g1_i2 Q95NI4 CALM_HALOK 2.00E-64 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Halichondria okadai (Marine sponge) (Reniera okadai) TR29057_c0_g1_i1 Q96MG7 MAGG1_HUMAN 8.00E-42 GO:0006310; GO:0006281; GO:0030915; GO:0000781; GO:0005737; GO:0005634; GO:0031398; GO:0040008; GO:0006355 Q8N140; Q8WV22; Q9NXX6; Q8NG27 "DNA recombination; DNA repair; Smc5-Smc6 complex; chromosome, telomeric region; cytoplasm; nucleus; positive regulation of protein ubiquitination; regulation of growth; regulation of transcription, DNA-dependent" IPR002190; Melanoma-associated antigen G1 (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Necdin-like protein 2) NDNL2 HCA4 MAGEG1 Homo sapiens (Human) TR29057_c0_g1_i2 Q9H213 MAGH1_HUMAN 5.00E-20 GO:0006915; GO:0005737 apoptotic process; cytoplasm IPR002190; Melanoma-associated antigen H1 (Apoptosis-related protein 1) (APR-1) (MAGE-H1 antigen) (Restin) MAGEH1 APR1 Homo sapiens (Human) TR29057_c0_g1_i3 Q9UJ55 MAGL2_HUMAN 9.00E-29 IPR002190; MAGE-like protein 2 (Necdin-like protein 1) (Protein nM15) MAGEL2 NDNL1 Homo sapiens (Human) TR29058_c0_g1_i1 P21158 CSGA_MYXXA 1.00E-35 GO:0005576; GO:0055114; GO:0016491; GO:0030435 extracellular region; oxidation-reduction process; oxidoreductase activity; sporulation resulting in formation of a cellular spore IPR002198; IPR002347; IPR016040; C-factor (C signal) csgA spoC Myxococcus xanthus TR29058_c0_g1_i2 P21158 CSGA_MYXXA 5.00E-34 GO:0005576; GO:0055114; GO:0016491; GO:0030435 extracellular region; oxidation-reduction process; oxidoreductase activity; sporulation resulting in formation of a cellular spore IPR002198; IPR002347; IPR016040; C-factor (C signal) csgA spoC Myxococcus xanthus TR29061_c0_g1_i1 O70422 TF2H4_MOUSE 0 GO:0004003; GO:0008353; GO:0000439; GO:0005675; GO:0006289; GO:0006355; GO:0006366 "ATP-dependent DNA helicase activity; RNA polymerase II carboxy-terminal domain kinase activity; core TFIIH complex; holo TFIIH complex; nucleotide-excision repair; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter" IPR004598; General transcription factor IIH subunit 4 (Basic transcription factor 2 52 kDa subunit) (BTF2 p52) (General transcription factor IIH polypeptide 4) (TFIIH basal transcription factor complex p52 subunit) Gtf2h4 Mus musculus (Mouse) TR29061_c0_g1_i2 O70422 TF2H4_MOUSE 3.00E-168 GO:0004003; GO:0008353; GO:0000439; GO:0005675; GO:0006289; GO:0006355; GO:0006366 "ATP-dependent DNA helicase activity; RNA polymerase II carboxy-terminal domain kinase activity; core TFIIH complex; holo TFIIH complex; nucleotide-excision repair; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter" IPR004598; General transcription factor IIH subunit 4 (Basic transcription factor 2 52 kDa subunit) (BTF2 p52) (General transcription factor IIH polypeptide 4) (TFIIH basal transcription factor complex p52 subunit) Gtf2h4 Mus musculus (Mouse) TR29062_c0_g1_i1 Q5R6Q7 SNX16_PONAB 9.00E-61 GO:0007154; GO:0005769; GO:0031901; GO:0045022; GO:0008333; GO:0031313; GO:0005770; GO:0031902; GO:0005764; GO:0035091; GO:0006622 cell communication; early endosome; early endosome membrane; early endosome to late endosome transport; endosome to lysosome transport; extrinsic to endosome membrane; late endosome; late endosome membrane; lysosome; phosphatidylinositol binding; protein targeting to lysosome IPR001683; Sorting nexin-16 SNX16 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR29064_c0_g1_i1 P70399 TP53B_MOUSE 5.00E-32 GO:0006281; GO:0000777; GO:0003684; GO:0000776; GO:0035064; GO:0005634; GO:0006355; GO:0005657; GO:0042162; GO:0008134; GO:0006351 "DNA repair; condensed chromosome kinetochore; damaged DNA binding; kinetochore; methylated histone residue binding; nucleus; regulation of transcription, DNA-dependent; replication fork; telomeric DNA binding; transcription factor binding; transcription, DNA-dependent" IPR015125; IPR001357; IPR014722; Tumor suppressor p53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Tp53bp1 Trp53bp1 Mus musculus (Mouse) TR29065_c0_g1_i1 Q25413 MYOM_LYMST 4.00E-11 GO:0005576; GO:0007218 extracellular region; neuropeptide signaling pathway Myomodulin neuropeptides [Cleaved into: GLQMLRL-amide; QIPMLRL-amide; SMSMLRL-amide; SLSMLRL-amide; Myomodulin-A (PMSMLRL-amide)] Lymnaea stagnalis (Great pond snail) TR29066_c2_g1_i1 Q9WYX8 Y508_THEMA 5.00E-17 GO:0005524; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0009378 ATP binding; DNA binding; DNA recombination; DNA repair; DNA replication; four-way junction helicase activity IPR003593; IPR008824; IPR008921; IPR002589; IPR021886; IPR027417; Uncharacterized protein TM_0508 TM_0508 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR29067_c0_g1_i1 A6NJI9 LRC72_HUMAN 1.00E-38 IPR001611; Leucine-rich repeat-containing protein 72 LRRC72 Homo sapiens (Human) TR29068_c0_g1_i2 P86179 CSL3_ONCKE 4.00E-20 GO:0030246 carbohydrate binding IPR000922; L-rhamnose-binding lectin CSL3 Oncorhynchus keta (Chum salmon) (Salmo keta) TR29069_c1_g1_i1 Q8R151 ZNFX1_MOUSE 3.00E-25 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR29069_c1_g1_i10 Q9P2E3 ZNFX1_HUMAN 1.00E-39 GO:0046872 metal ion binding IPR016024; IPR027417; NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) TR29069_c1_g1_i2 Q8R151 ZNFX1_MOUSE 6.00E-38 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR29069_c1_g1_i3 Q9P2E3 ZNFX1_HUMAN 5.00E-41 GO:0046872 metal ion binding IPR016024; IPR027417; NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) TR29070_c6_g1_i1 O73791 TIE2_DANRE 1.00E-11 GO:0005524; GO:0005737; GO:0005856; GO:0005925; GO:0007507; GO:0005887; GO:0018108; GO:0004714; GO:0007169 ATP binding; cytoplasm; cytoskeleton; focal adhesion; heart development; integral to plasma membrane; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000742; IPR013032; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR011009; IPR000719; IPR017441; IPR001245; IPR018941; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-2 (EC 2.7.10.1) (Tyrosine kinase with Ig and EGF homology domains-2) tie2 tie-2 Danio rerio (Zebrafish) (Brachydanio rerio) TR29071_c1_g1_i1 Q7SIB2 CO4A1_BOVIN 3.00E-41 GO:0071230; GO:0005587; GO:0005201; GO:0007528 cellular response to amino acid stimulus; collagen type IV; extracellular matrix structural constituent; neuromuscular junction development IPR016187; IPR001442; Collagen alpha-1(IV) chain (Fragment) COL4A1 Bos taurus (Bovine) TR29074_c0_g1_i1 Q5H9U9 DDX6L_HUMAN 8.00E-18 GO:0005524; GO:0008026; GO:0003723 ATP binding; ATP-dependent helicase activity; RNA binding IPR011545; IPR014001; IPR001650; IPR027417; Probable ATP-dependent RNA helicase DDX60-like (EC 3.6.4.13) (DEAD box protein 60-like) DDX60L Homo sapiens (Human) TR29074_c0_g2_i1 Q15477 SKIV2_HUMAN 0 GO:0005524; GO:0004004; GO:0003723; GO:0055087; GO:0005634 ATP binding; ATP-dependent RNA helicase activity; RNA binding; Ski complex; nucleus IPR011545; IPR012961; IPR014001; IPR001650; IPR027417; IPR016438; IPR025696; Helicase SKI2W (Ski2) (EC 3.6.4.-) (Helicase-like protein) (HLP) SKIV2L DDX13 SKI2W SKIV2 W Homo sapiens (Human) TR29076_c5_g3_i2 Q5PQ71 ISOC2_XENLA 3.00E-10 GO:0003824; GO:0005739 catalytic activity; mitochondrion IPR000868; "Isochorismatase domain-containing protein 2, mitochondrial" isoc2 Xenopus laevis (African clawed frog) TR29077_c0_g1_i1 Q8RY60 Y1733_ARATH 2.00E-23 GO:0030554; GO:0016021; GO:0005886 adenyl nucleotide binding; integral to membrane; plasma membrane IPR000644; IPR002550; DUF21 domain-containing protein At1g47330 (CBS domain-containing protein CBSDUF7) CBSDUF7 At1g47330 T3F24.6 Arabidopsis thaliana (Mouse-ear cress) TR29077_c1_g1_i1 Q9NRU3 CNNM1_HUMAN 2.00E-16 GO:0030554; GO:0016021; GO:0006811; GO:0005886 adenyl nucleotide binding; integral to membrane; ion transport; plasma membrane IPR000644; IPR002550; Metal transporter CNNM1 (Ancient conserved domain-containing protein 1) (Cyclin-M1) CNNM1 ACDP1 Homo sapiens (Human) TR29077_c1_g2_i1 Q8VZI2 Y4370_ARATH 2.00E-26 GO:0030554; GO:0016021; GO:0005886 adenyl nucleotide binding; integral to membrane; plasma membrane IPR000644; IPR002550; DUF21 domain-containing protein At4g33700 (CBS domain-containing protein CBSDUF6) CBSDUF6 At4g33700 T16L1_190 Arabidopsis thaliana (Mouse-ear cress) TR29078_c2_g1_i1 Q1RJR6 Y317_RICBR 9.00E-22 IPR002110; IPR020683; Putative ankyrin repeat protein RBE_0317 RBE_0317 Rickettsia bellii (strain RML369-C) TR29078_c2_g1_i2 Q9Z2G0 FEM1B_MOUSE 1.00E-11 GO:0006915; GO:0060442; GO:0005737; GO:0060743; GO:0005634; GO:0016567; GO:2000001; GO:1902041; GO:0051438; GO:0004842 apoptotic process; branching involved in prostate gland morphogenesis; cytoplasm; epithelial cell maturation involved in prostate gland development; nucleus; protein ubiquitination; regulation of DNA damage checkpoint; regulation of extrinsic apoptotic signaling pathway via death domain receptors; regulation of ubiquitin-protein ligase activity; ubiquitin-protein ligase activity IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha) (mt-Fem) Fem1b F1aa Kiaa0396 Mus musculus (Mouse) TR29078_c2_g2_i1 Q6S5J6 KRIT1_MOUSE 1.00E-07 GO:0001525; GO:0045454; GO:0005911; GO:0005737; GO:0005874; GO:0008017; GO:0016525; GO:2000352; GO:0010596; GO:0001937; GO:0005546; GO:0005886; GO:0032092; GO:2000114; GO:0005083 "angiogenesis; cell redox homeostasis; cell-cell junction; cytoplasm; microtubule; microtubule binding; negative regulation of angiogenesis; negative regulation of endothelial cell apoptotic process; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; phosphatidylinositol-4,5-bisphosphate binding; plasma membrane; positive regulation of protein binding; regulation of establishment of cell polarity; small GTPase regulator activity" IPR002110; IPR020683; IPR019749; IPR014352; IPR019748; IPR000299; Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog) Krit1 Ccm1 Mus musculus (Mouse) TR29078_c2_g3_i1 Q10311 YD58_SCHPO 3.00E-13 GO:0005829; GO:0005634; GO:0043161; GO:0005838 cytosol; nucleus; proteasomal ubiquitin-dependent protein catabolic process; proteasome regulatory particle IPR002110; IPR020683; Ankyrin repeat-containing protein C6C3.08 SPAC6C3.08 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR29078_c2_g3_i3 P16157 ANK1_HUMAN 1.00E-21 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR29078_c2_g4_i1 Q6JAN1 INVS_CANFA 5.00E-16 GO:0016055; GO:0005737; GO:0060971; GO:0001822; GO:0016020; GO:0005874; GO:0090090; GO:0005634; GO:0031016; GO:0009791; GO:0005819 Wnt receptor signaling pathway; cytoplasm; embryonic heart tube left/right pattern formation; kidney development; membrane; microtubule; negative regulation of canonical Wnt receptor signaling pathway; nucleus; pancreas development; post-embryonic development; spindle IPR002110; IPR020683; IPR000048; Inversin (Inversion of embryo turning protein) (Nephrocystin-2) INVS INV NPHP2 Canis familiaris (Dog) (Canis lupus familiaris) TR29079_c0_g1_i1 Q96JN0 LCOR_HUMAN 8.00E-06 GO:0003677; GO:0000122; GO:0005634; GO:0003700; GO:0006366 DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter IPR009057; IPR007889; Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2) LCOR KIAA1795 MLR2 Homo sapiens (Human) TR29084_c0_g2_i1 Q8NA03 FSIP1_HUMAN 2.00E-07 IPR026246; Fibrous sheath-interacting protein 1 FSIP1 HSD10 Homo sapiens (Human) TR29085_c3_g1_i1 P62071 RRAS2_MOUSE 2.00E-93 GO:0005525; GO:0003924; GO:0007265; GO:0005622; GO:0005886; GO:0030335 GTP binding; GTPase activity; Ras protein signal transduction; intracellular; plasma membrane; positive regulation of cell migration IPR027417; IPR005225; IPR001806; IPR020849; Ras-related protein R-Ras2 Rras2 Mus musculus (Mouse) TR29089_c2_g2_i1 Q8LGU7 RNZN_ARATH 5.00E-52 GO:0042781; GO:0046872; GO:0005634; GO:0042780 3'-tRNA processing endoribonuclease activity; metal ion binding; nucleus; tRNA 3'-end processing IPR001279; Nuclear ribonuclease Z (RNase Z) (EC 3.1.26.11) (Zinc phosphodiesterase NUZ) (tRNA 3 endonuclease) (tRNase Z) NUZ At1g74700 F1M20.38 F25A4.32 Arabidopsis thaliana (Mouse-ear cress) TR29090_c0_g1_i1 Q91642 PEPE_XENLA 2.00E-118 GO:0005737; GO:0016805; GO:0006508; GO:0008236 cytoplasm; dipeptidase activity; proteolysis; serine-type peptidase activity IPR005320; Alpha-aspartyl dipeptidase (EC 3.4.13.21) (Asp-specific dipeptidase) (Dipeptidase E) aad-a Xenopus laevis (African clawed frog) TR29092_c1_g1_i1 Q10N05 GT32_ORYSJ 8.00E-09 GO:0000139; GO:0015018; GO:0016021 Golgi membrane; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity; integral to membrane IPR005027; Probable glucuronosyltransferase Os03g0287800 (EC 2.4.-.-) Os03g0287800 LOC_Os03g17850 Oryza sativa subsp. japonica (Rice) TR29092_c1_g1_i2 Q9WU47 B3GA3_CRIGR 7.00E-97 GO:0000139; GO:0015018; GO:0016021; GO:0046872; GO:0006486 Golgi membrane; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity; integral to membrane; metal ion binding; protein glycosylation IPR005027; Protein modification; protein glycosylation. "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 3) (Glucuronosyltransferase I) (GlcAT-I) (UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase) (GlcUAT-I)" B3GAT3 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR29094_c1_g1_i1 Q6PAL0 BEND3_MOUSE 6.00E-08 IPR018379; BEN domain-containing protein 3 Bend3 Kiaa1553 Mus musculus (Mouse) TR29095_c0_g1_i1 P11928 OAS1A_MOUSE 7.00E-22 GO:0001730; GO:0005524; GO:0051607; GO:0003725; GO:0005783; GO:0045087; GO:0046872; GO:0005739; GO:0005634; GO:0006164; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; defense response to virus; double-stranded RNA binding; endoplasmic reticulum; innate immune response; metal ion binding; mitochondrion; nucleus; purine nucleotide biosynthetic process; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 1A ((2-5')oligo(A) synthase 1A) (2-5A synthase 1A) (EC 2.7.7.84) (p42 OAS) Oas1a Oias1 Mus musculus (Mouse) TR29095_c0_g1_i2 Q8VI93 OAS3_MOUSE 9.00E-46 GO:0001730; GO:0005524; GO:0005737; GO:0051607; GO:0003725; GO:0045087; GO:0046872; GO:0045071; GO:0005634; GO:0060700; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; cytoplasm; defense response to virus; double-stranded RNA binding; innate immune response; metal ion binding; negative regulation of viral genome replication; nucleus; regulation of ribonuclease activity; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; "2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (2',5'-oligoadenylate synthetase-like 10)" Oas3 oasl10 Mus musculus (Mouse) TR29097_c0_g2_i1 P36032 MCH2_YEAST 9.00E-06 GO:0016021; GO:0016020; GO:0015293; GO:0005215 integral to membrane; membrane; symporter activity; transporter activity IPR011701; IPR016196; Probable transporter MCH2 MCH2 YKL221W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR29097_c0_g2_i6 Q6GM59 MOT12_XENLA 2.00E-40 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 Xenopus laevis (African clawed frog) TR29099_c0_g1_i1 Q3URF8 KCD21_MOUSE 1.00E-32 GO:0051260 protein homooligomerization IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein KCTD21 Kctd21 Mus musculus (Mouse) TR29099_c0_g1_i2 Q6DG99 KCTD6_DANRE 5.00E-37 GO:0051260 protein homooligomerization IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein KCTD6 kctd6 zgc:91884 Danio rerio (Zebrafish) (Brachydanio rerio) TR29106_c0_g1_i1 Q6P1V8 MCM6Z_XENTR 0 GO:0005524; GO:0003677; GO:0032508; GO:0003678; GO:0006270; GO:0042555; GO:0007049; GO:0046872; GO:0005634 ATP binding; DNA binding; DNA duplex unwinding; DNA helicase activity; DNA replication initiation; MCM complex; cell cycle; metal ion binding; nucleus IPR008049; IPR018525; IPR001208; IPR027925; IPR012340; IPR027417; IPR004039; Zygotic DNA replication licensing factor mcm6 (EC 3.6.4.12) (Zygotic minichromosome maintenance protein 6) (zMCM6) zmcm6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR29107_c0_g1_i4 Q7T3C6 CPSF5_DANRE 2.00E-124 GO:0017091; GO:0016787; GO:0003729; GO:0005849; GO:0006378; GO:0042382 AU-rich element binding; hydrolase activity; mRNA binding; mRNA cleavage factor complex; mRNA polyadenylation; paraspeckles IPR016706; IPR000086; IPR015797; Cleavage and polyadenylation specificity factor subunit 5 cpsf5 Danio rerio (Zebrafish) (Brachydanio rerio) TR29108_c1_g1_i2 Q24JV4 U390_DANRE 8.00E-09 IPR019034; UPF0390 protein zgc136864 zgc:136864 Danio rerio (Zebrafish) (Brachydanio rerio) TR29111_c0_g1_i1 P39849 XYLB_PSEPU 2.00E-08 GO:0019439; GO:0018456; GO:0008270 aromatic compound catabolic process; aryl-alcohol dehydrogenase (NAD+) activity; zinc ion binding IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; Aryl-alcohol dehydrogenase (EC 1.1.1.90) (Benzyl alcohol dehydrogenase) (BADH) xylB Pseudomonas putida (Arthrobacter siderocapsulatus) TR29111_c0_g1_i2 Q58D31 DHSO_BOVIN 6.00E-105 GO:0003939; GO:0051160; GO:0051287; GO:0046370; GO:0031966; GO:0031514; GO:0006062; GO:0030317; GO:0008270 L-iditol 2-dehydrogenase activity; L-xylitol catabolic process; NAD binding; fructose biosynthetic process; mitochondrial membrane; motile cilium; sorbitol catabolic process; sperm motility; zinc ion binding IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase) SORD Bos taurus (Bovine) TR29113_c0_g2_i1 Q08BZ4 MDH1B_DANRE 5.00E-48 GO:0005975; GO:0016615; GO:0006108; GO:0016616; GO:0006099 "carbohydrate metabolic process; malate dehydrogenase activity; malate metabolic process; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; tricarboxylic acid cycle" IPR022383; IPR015955; IPR010945; Putative malate dehydrogenase 1B (EC 1.1.1.-) mdh1b zgc:153922 Danio rerio (Zebrafish) (Brachydanio rerio) TR29113_c0_g3_i1 Q7NZ60 MDH_CHRVO 3.00E-17 GO:0030060; GO:0044262; GO:0006108; GO:0006099 L-malate dehydrogenase activity; cellular carbohydrate metabolic process; malate metabolic process; tricarboxylic acid cycle IPR001557; IPR022383; IPR001236; IPR015955; IPR010945; IPR016040; Malate dehydrogenase (EC 1.1.1.37) mdh CV_1062 Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757) TR29113_c0_g3_i2 Q8T773 MDH1B_BRAFL 1.00E-75 GO:0005975; GO:0045454; GO:0009055; GO:0016615; GO:0006108; GO:0016616; GO:0015035; GO:0006099 "carbohydrate metabolic process; cell redox homeostasis; electron carrier activity; malate dehydrogenase activity; malate metabolic process; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein disulfide oxidoreductase activity; tricarboxylic acid cycle" IPR002109; IPR022383; IPR001236; IPR015955; IPR010945; IPR016040; Putative malate dehydrogenase 1B (EC 1.1.1.-) MDH1B Branchiostoma floridae (Florida lancelet) (Amphioxus) TR29115_c0_g1_i2 Q0MQC8 NDUB2_GORGO 3.00E-10 GO:0005747; GO:0055114 mitochondrial respiratory chain complex I; oxidation-reduction process IPR026627; "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (Complex I-AGGG) (CI-AGGG) (NADH-ubiquinone oxidoreductase AGGG subunit)" NDUFB2 Gorilla gorilla gorilla (Lowland gorilla) TR29116_c0_g1_i2 Q6PFY8 TRI45_MOUSE 3.00E-07 GO:0060348; GO:0005737; GO:0005634; GO:0008270 bone development; cytoplasm; nucleus; zinc ion binding IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) TR29121_c1_g1_i1 Q9P2K1 C2D2A_HUMAN 8.00E-36 GO:0036038; GO:0042384; GO:0005737; GO:0005932; GO:0007224 TCTN-B9D complex; cilium assembly; cytoplasm; microtubule basal body; smoothened signaling pathway IPR000008; Coiled-coil and C2 domain-containing protein 2A CC2D2A KIAA1345 Homo sapiens (Human) TR29121_c1_g1_i2 Q9P2K1 C2D2A_HUMAN 7.00E-36 GO:0036038; GO:0042384; GO:0005737; GO:0005932; GO:0007224 TCTN-B9D complex; cilium assembly; cytoplasm; microtubule basal body; smoothened signaling pathway IPR000008; Coiled-coil and C2 domain-containing protein 2A CC2D2A KIAA1345 Homo sapiens (Human) TR29122_c0_g1_i1 O81908 PPR2_ARATH 8.00E-09 GO:0009507 chloroplast IPR002885; IPR011990; "Pentatricopeptide repeat-containing protein At1g02060, chloroplastic" At1g02060 T7I23.14 Arabidopsis thaliana (Mouse-ear cress) TR29122_c0_g1_i2 A2VD13 PTCD1_RAT 1.00E-65 GO:0005759; GO:0042780; GO:0000049 mitochondrial matrix; tRNA 3'-end processing; tRNA binding IPR002885; "Pentatricopeptide repeat-containing protein 1, mitochondrial" Ptcd1 Rattus norvegicus (Rat) TR29125_c2_g2_i1 B4L8V5 CUE_DROMO 2.00E-06 GO:0030154; GO:0016021; GO:0048477; GO:0005886; GO:0007283 cell differentiation; integral to membrane; oogenesis; plasma membrane; spermatogenesis IPR011042; IPR000742; IPR013032; IPR000033; Protein cueball cue GI16721 Drosophila mojavensis (Fruit fly) TR29129_c2_g1_i1 Q32L00 ALKB3_BOVIN 2.00E-90 GO:0006307; GO:0043734; GO:0008283; GO:0051747; GO:0008198; GO:0005739; GO:0005634; GO:0035552 DNA dealkylation involved in DNA repair; DNA-N1-methyladenine dioxygenase activity; cell proliferation; cytosine C-5 DNA demethylase activity; ferrous iron binding; mitochondrion; nucleus; oxidative single-stranded DNA demethylation IPR027450; IPR005123; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 3) ALKBH3 ABH3 Bos taurus (Bovine) TR29130_c0_g1_i2 A2BIG9 LSMD1_DANRE 7.00E-30 IPR010920; IPR001163; IPR006649; LSM domain-containing protein 1 lsmd1 si:ch211-30G3.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR29133_c0_g2_i1 Q91W34 CP058_MOUSE 6.00E-92 GO:0016021 integral to membrane IPR006968; UPF0420 protein C16orf58 homolog Mus musculus (Mouse) TR29137_c0_g1_i1 Q9BT17 MTG1_HUMAN 3.00E-93 GO:0005525; GO:0003924; GO:0005743; GO:0005761; GO:0005634; GO:0070129; GO:0044065; GO:0042254 P04156 GTP binding; GTPase activity; mitochondrial inner membrane; mitochondrial ribosome; nucleus; regulation of mitochondrial translation; regulation of respiratory system process; ribosome biogenesis IPR023179; IPR019991; IPR006073; IPR016478; IPR027417; Mitochondrial ribosome-associated GTPase 1 (GTP-binding protein 7) (Mitochondrial GTPase 1) MTG1 GTPBP7 Homo sapiens (Human) TR29138_c0_g1_i1 Q91VN0 LRP5_MOUSE 2.00E-08 GO:0044332; GO:0042813; GO:0060612; GO:0060033; GO:0009952; GO:1902262; GO:0048539; GO:0060349; GO:0046849; GO:0060444; GO:0060070; GO:0042074; GO:0060764; GO:0042632; GO:0008203; GO:0015026; GO:0048596; GO:0042733; GO:0060059; GO:0006897; GO:0005783; GO:0035426; GO:0001702; GO:0016021; GO:0005739; GO:0002076; GO:0005886; GO:0033690; GO:0051091; GO:0045944; GO:0043235; GO:0042981; GO:0046850; GO:0045598; GO:0061178; GO:0030278; GO:0061304; GO:0035019 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt-activated receptor activity; adipose tissue development; anatomical structure regression; anterior/posterior pattern specification; apoptotic process involved in patterning of blood vessels; bone marrow development; bone morphogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway; cell migration involved in gastrulation; cell-cell signaling involved in mammary gland development; cholesterol homeostasis; cholesterol metabolic process; coreceptor activity; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic retina morphogenesis in camera-type eye; endocytosis; endoplasmic reticulum; extracellular matrix-cell signaling; gastrulation with mouth forming second; integral to membrane; mitochondrion; osteoblast development; plasma membrane; positive regulation of osteoblast proliferation; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; receptor complex; regulation of apoptotic process; regulation of bone remodeling; regulation of fat cell differentiation; regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of ossification; retinal blood vessel morphogenesis; somatic stem cell maintenance IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7) (Lr3) Lrp5 Lrp7 Mus musculus (Mouse) TR29139_c2_g3_i1 Q9W6R5 XLRS1_TAKRU 2.00E-18 GO:0007155; GO:0005576 cell adhesion; extracellular region IPR000421; IPR008979; Retinoschisin (X-linked juvenile retinoschisis protein homolog) xlrs1 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR29139_c2_g3_i2 Q9D2L5 CPXM2_MOUSE 1.00E-19 GO:0007155; GO:0031012; GO:0005576; GO:0008270 cell adhesion; extracellular matrix; extracellular region; zinc ion binding IPR008969; IPR014766; IPR000421; IPR008979; IPR000834; Inactive carboxypeptidase-like protein X2 Cpxm2 Cpx2 Mus musculus (Mouse) TR2914_c0_g1_i1 Q3ZBZ8 STIP1_BOVIN 4.00E-48 GO:0005737; GO:0005634 cytoplasm; nucleus IPR006636; IPR013026; IPR011990; IPR001440; IPR019734; Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) STIP1 Bos taurus (Bovine) TR29141_c0_g4_i1 Q84MN0 CML4_ORYSJ 4.00E-06 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-like protein 4 CML4 Os03g0743500 LOC_Os03g53200 OSJNBb0036F07.4 Oryza sativa subsp. japonica (Rice) TR29143_c0_g1_i1 Q80ZI6 LRSM1_MOUSE 2.00E-10 GO:0005737; GO:0016020; GO:0045806; GO:0051865; GO:0030163; GO:0000209; GO:0015031; GO:0070086; GO:0004842; GO:0046755; GO:0008270 cytoplasm; membrane; negative regulation of endocytosis; protein autoubiquitination; protein catabolic process; protein polyubiquitination; protein transport; ubiquitin-dependent endocytosis; ubiquitin-protein ligase activity; viral budding; zinc ion binding IPR001611; IPR025875; IPR001660; IPR013761; IPR011510; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) Lrsam1 Mus musculus (Mouse) TR29143_c0_g1_i2 Q80ZI6 LRSM1_MOUSE 3.00E-10 GO:0005737; GO:0016020; GO:0045806; GO:0051865; GO:0030163; GO:0000209; GO:0015031; GO:0070086; GO:0004842; GO:0046755; GO:0008270 cytoplasm; membrane; negative regulation of endocytosis; protein autoubiquitination; protein catabolic process; protein polyubiquitination; protein transport; ubiquitin-dependent endocytosis; ubiquitin-protein ligase activity; viral budding; zinc ion binding IPR001611; IPR025875; IPR001660; IPR013761; IPR011510; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) Lrsam1 Mus musculus (Mouse) TR29145_c0_g1_i1 P09527 RAB7A_RAT 6.00E-50 GO:0019003; GO:0005525; GO:0003924; GO:0005794; GO:0097208; GO:0045453; GO:0045022; GO:0008333; GO:0007174; GO:0005770; GO:0005764; GO:0042470; GO:0045335; GO:0030670; GO:0090383; GO:0090385; GO:0006622; GO:0007264 P37727 GDP binding; GTP binding; GTPase activity; Golgi apparatus; alveolar lamellar body; bone resorption; early endosome to late endosome transport; endosome to lysosome transport; epidermal growth factor catabolic process; late endosome; lysosome; melanosome; phagocytic vesicle; phagocytic vesicle membrane; phagosome acidification; phagosome-lysosome fusion; protein targeting to lysosome; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-7a (Ras-related protein BRL-RAS) (Ras-related protein p23) Rab7a Rab7 Rattus norvegicus (Rat) TR29145_c0_g1_i2 Q06AU5 RAB32_PIG 4.00E-14 GO:0005525; GO:0005739; GO:0045335; GO:0030670; GO:0090382; GO:0015031; GO:0007264 GTP binding; mitochondrion; phagocytic vesicle; phagocytic vesicle membrane; phagosome maturation; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-32 RAB32 Sus scrofa (Pig) TR29145_c0_g1_i3 P97348 RHOD_MOUSE 5.00E-10 GO:0005525; GO:0005769; GO:0005886; GO:0007264 GTP binding; early endosome; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Rho-related GTP-binding protein RhoD Rhod Arhd Rhom Mus musculus (Mouse) TR2915_c0_g1_i1 Q1LVZ2 MARH2_DANRE 1.00E-17 GO:0031410; GO:0006897; GO:0005783; GO:0005789; GO:0010008; GO:0030097; GO:0016021; GO:0005765; GO:0004842; GO:0008270 cytoplasmic vesicle; endocytosis; endoplasmic reticulum; endoplasmic reticulum membrane; endosome membrane; hemopoiesis; integral to membrane; lysosomal membrane; ubiquitin-protein ligase activity; zinc ion binding IPR011016; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MARCH2 (EC 6.3.2.-) (Membrane-associated RING finger protein 2) (Membrane-associated RING-CH protein II) (MARCH-II) march2 si:ch211-197g15.3 zgc:158704 Danio rerio (Zebrafish) (Brachydanio rerio) TR29151_c0_g1_i2 P04047 KITH_CHICK 9.00E-79 GO:0005524; GO:0006260; GO:0005737; GO:0051289; GO:0004797; GO:0008270 Itself ATP binding; DNA replication; cytoplasm; protein homotetramerization; thymidine kinase activity; zinc ion binding IPR027417; IPR001267; IPR020633; "Thymidine kinase, cytosolic (EC 2.7.1.21)" TK1 Gallus gallus (Chicken) TR29152_c2_g1_i1 Q6V0K7 OIT3_RAT 2.00E-15 GO:0005635 nuclear envelope IPR000742; IPR001507; Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein) Oit3 Lzp Rattus norvegicus (Rat) TR29152_c2_g1_i3 Q6V0K7 OIT3_RAT 2.00E-15 GO:0005635 nuclear envelope IPR000742; IPR001507; Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein) Oit3 Lzp Rattus norvegicus (Rat) TR29153_c0_g1_i2 Q9UFG5 CS025_HUMAN 9.00E-06 Q15834 IPR028227; UPF0449 protein C19orf25 C19orf25 Homo sapiens (Human) TR29154_c2_g1_i1 Q04833 LRP_CAEEL 9.00E-15 GO:0016324; GO:0005509; GO:0005905; GO:0042395; GO:0030139; GO:0006897; GO:0016021; GO:0002119; GO:0040017; GO:0040018; GO:0030334; GO:0015248 "apical plasma membrane; calcium ion binding; coated pit; ecdysis, collagen and cuticulin-based cuticle; endocytic vesicle; endocytosis; integral to membrane; nematode larval development; positive regulation of locomotion; positive regulation of multicellular organism growth; regulation of cell migration; sterol transporter activity" IPR011042; IPR000742; IPR001881; IPR013032; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein (LRP) lrp-1 F29D11.1 Caenorhabditis elegans TR29155_c0_g1_i1 O58440 VAPC6_PYRHO 1.00E-07 GO:0004519; GO:0000287; GO:0090305; GO:0019843; GO:0004540; GO:0042254 endonuclease activity; magnesium ion binding; nucleic acid phosphodiester bond hydrolysis; rRNA binding; ribonuclease activity; ribosome biogenesis IPR002716; IPR022785; IPR022907; Endoribonuclease Nob1 (RNase Nob1) (EC 3.1.-.-) (Endonuclease VapC6) (Putative toxin VapC6) nob1 vapC6 PH0709 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) TR29155_c0_g2_i1 Q3T042 NOB1_BOVIN 3.00E-67 GO:0046872; GO:0005634 metal ion binding; nucleus IPR017117; IPR014881; IPR002716; RNA-binding protein NOB1 NOB1 Bos taurus (Bovine) TR29157_c0_g2_i1 A5WW21 RASEF_DANRE 2.00E-06 GO:0005525; GO:0005509; GO:0048471; GO:0015031; GO:0007264 GTP binding; calcium ion binding; perinuclear region of cytoplasm; protein transport; small GTPase mediated signal transduction IPR011992; IPR018247; IPR002048; IPR027417; IPR005225; IPR001806; IPR003579; Ras and EF-hand domain-containing protein rasef si:ch211-39k3.1 zgc:162879 Danio rerio (Zebrafish) (Brachydanio rerio) TR29157_c1_g3_i1 P70550 RAB8B_RAT 1.00E-16 GO:0019003; GO:0005525; GO:0034332; GO:0051286; GO:0005739; GO:0048471; GO:0005778; GO:0045335; GO:0030670; GO:0005886; GO:0031346; GO:0051461; GO:0045046; GO:0007264 GDP binding; GTP binding; adherens junction organization; cell tip; mitochondrion; perinuclear region of cytoplasm; peroxisomal membrane; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane; positive regulation of cell projection organization; positive regulation of corticotropin secretion; protein import into peroxisome membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-8B Rab8b Rattus norvegicus (Rat) TR29157_c1_g3_i2 P41924 RYL1_YARLI 3.00E-18 GO:0005525; GO:0005886; GO:0015031; GO:0007264 GTP binding; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-like GTP-binding protein RYL1 RYL1 YALI0E23067g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR29157_c1_g3_i3 P17609 YPT2_SCHPO 6.00E-17 GO:0005525; GO:0003924; GO:0006893; GO:0005829; GO:0006887; GO:0006886; GO:0005634; GO:0005886; GO:0007264; GO:0006906 GTP binding; GTPase activity; Golgi to plasma membrane transport; cytosol; exocytosis; intracellular protein transport; nucleus; plasma membrane; small GTPase mediated signal transduction; vesicle fusion IPR027417; IPR005225; IPR001806; IPR003579; GTP-binding protein ypt2 (SEC4 homolog) ypt2 SPAC9E9.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR29157_c1_g3_i4 Q92930 RAB8B_HUMAN 2.00E-16 GO:0019003; GO:0005525; GO:0003924; GO:0034332; GO:0051286; GO:0005739; GO:0048471; GO:0005778; GO:0045335; GO:0030670; GO:0005886; GO:0031346; GO:0051461; GO:0045046; GO:0007264 GDP binding; GTP binding; GTPase activity; adherens junction organization; cell tip; mitochondrion; perinuclear region of cytoplasm; peroxisomal membrane; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane; positive regulation of cell projection organization; positive regulation of corticotropin secretion; protein import into peroxisome membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-8B RAB8B Homo sapiens (Human) TR29161_c0_g1_i1 Q6NRK9 FA58A_XENLA 5.00E-83 GO:0000079; GO:0006355 "regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription, DNA-dependent" IPR013763; IPR015429; IPR006671; Cyclin-related protein FAM58A fam58a Xenopus laevis (African clawed frog) TR29163_c1_g1_i2 Q64LD2 WDR25_HUMAN 1.00E-65 IPR015943; IPR001680; IPR017986; WD repeat-containing protein 25 WDR25 Homo sapiens (Human) TR29164_c0_g1_i1 Q12981 SEC20_HUMAN 2.00E-31 GO:0031201; GO:0006914; GO:0016320; GO:0007029; GO:0097194; GO:0030176; GO:0005739; GO:0043066; GO:0005635; GO:0016192 SNARE complex; autophagy; endoplasmic reticulum membrane fusion; endoplasmic reticulum organization; execution phase of apoptosis; integral to endoplasmic reticulum membrane; mitochondrion; negative regulation of apoptotic process; nuclear envelope; vesicle-mediated transport IPR005606; Vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 1) (Transformation-related gene 8 protein) (TRG-8) BNIP1 NIP1 SEC20L TRG8 Homo sapiens (Human) TR29166_c0_g1_i1 P60901 PSA6_RAT 2.00E-151 GO:0003723; GO:0000932; GO:0016363; GO:0005844; GO:0051092; GO:0019773; GO:0051603; GO:0030017; GO:0004298; GO:0006511 "RNA binding; cytoplasmic mRNA processing body; nuclear matrix; polysome; positive regulation of NF-kappaB transcription factor activity; proteasome core complex, alpha-subunit complex; proteolysis involved in cellular protein catabolic process; sarcomere; threonine-type endopeptidase activity; ubiquitin-dependent protein catabolic process" IPR000426; IPR023332; IPR001353; Proteasome subunit alpha type-6 (EC 3.4.25.1) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain) Psma6 Rattus norvegicus (Rat) TR29167_c1_g1_i1 Q9DG02 KCC2D_XENLA 0 GO:0005524; GO:0004683 ATP binding; calmodulin-dependent protein kinase activity IPR020636; IPR013543; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium/calmodulin-dependent protein kinase type II delta chain (CaM kinase II subunit delta) (CaM-kinase II delta chain) (CaMK-II subunit delta) (EC 2.7.11.17) camk2d Xenopus laevis (African clawed frog) TR29169_c0_g1_i1 Q6GMG8 LITAF_DANRE 9.00E-19 GO:0005737; GO:0006355; GO:0006351 "cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) litaf zgc:91882 Danio rerio (Zebrafish) (Brachydanio rerio) TR29172_c0_g1_i1 Q4R4W5 IDI1_MACFA 1.00E-70 GO:0006695; GO:0050992; GO:0016787; GO:0004452; GO:0008299; GO:0046872; GO:0005777 cholesterol biosynthetic process; dimethylallyl diphosphate biosynthetic process; hydrolase activity; isopentenyl-diphosphate delta-isomerase activity; isoprenoid biosynthetic process; metal ion binding; peroxisome IPR011876; IPR000086; IPR015797; Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1. Isopentenyl-diphosphate Delta-isomerase 1 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 1) (IPP isomerase 1) (IPPI1) IDI1 QtrA-12624 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR29172_c0_g1_i3 Q39472 IDI1_CLABR 1.00E-73 GO:0015995; GO:0050992; GO:0016787; GO:0004452; GO:0008299; GO:0015979 chlorophyll biosynthetic process; dimethylallyl diphosphate biosynthetic process; hydrolase activity; isopentenyl-diphosphate delta-isomerase activity; isoprenoid biosynthetic process; photosynthesis IPR011876; IPR000086; IPR015797; Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1. Porphyrin-containing compound metabolism; chlorophyll biosynthesis. Isopentenyl-diphosphate Delta-isomerase I (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase I) (IPP isomerase I) IPI1 Clarkia breweri (Fairy fans) (Eucharidium breweri) TR29172_c0_g1_i4 Q82MJ7 IDI_STRAW 1.00E-16 GO:0005737; GO:0050992; GO:0016787; GO:0004452; GO:0008299; GO:0046872 cytoplasm; dimethylallyl diphosphate biosynthetic process; hydrolase activity; isopentenyl-diphosphate delta-isomerase activity; isoprenoid biosynthetic process; metal ion binding IPR011876; IPR000086; IPR015797; Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1. Isopentenyl-diphosphate Delta-isomerase (IPP isomerase) (EC 5.3.3.2) (IPP:DMAPP isomerase) (Isopentenyl pyrophosphate isomerase) idi SAV_1663 Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680) TR29172_c0_g1_i5 P58044 IDI1_MOUSE 2.00E-89 GO:0006695; GO:0050992; GO:0016787; GO:0004452; GO:0008299; GO:0000287; GO:0030145; GO:0005739; GO:0005777; GO:0035634 cholesterol biosynthetic process; dimethylallyl diphosphate biosynthetic process; hydrolase activity; isopentenyl-diphosphate delta-isomerase activity; isoprenoid biosynthetic process; magnesium ion binding; manganese ion binding; mitochondrion; peroxisome; response to stilbenoid IPR011876; IPR000086; IPR015797; Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1. Isopentenyl-diphosphate Delta-isomerase 1 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 1) (IPP isomerase 1) (IPPI1) Idi1 Mus musculus (Mouse) TR29173_c0_g1_i1 Q04310 Y4629_STRCO 1.00E-34 GO:0003677 DNA binding IPR003848; IPR014729; Uncharacterized protein SCO4629 SCO4629 SCD39.29 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) TR29174_c0_g1_i1 Q9ES88 S13A2_MOUSE 7.00E-104 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR001898; Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter) Slc13a2 Nadc1 Sdct1 Mus musculus (Mouse) TR29175_c2_g1_i1 Q7LHG5 YI31B_YEAST 2.00E-16 GO:0005524; GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0005737; GO:0008233; GO:0006508; GO:0000943; GO:0004523; GO:0004540; GO:0032197; GO:0046797; GO:0008270 "ATP binding; DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; cytoplasm; peptidase activity; proteolysis; retrotransposon nucleocapsid; ribonuclease H activity; ribonuclease activity; transposition, RNA-mediated; viral procapsid maturation; zinc ion binding" IPR001584; IPR024650; IPR021109; IPR005162; IPR012337; IPR000477; IPR001878; Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR29177_c1_g1_i1 Q09172 PP2C2_SCHPO 2.00E-10 GO:0071470; GO:0005829; GO:0030968; GO:0000173; GO:0046872; GO:0005634; GO:0006470; GO:0004722 cellular response to osmotic stress; cytosol; endoplasmic reticulum unfolded protein response; inactivation of MAPK activity involved in osmosensory signaling pathway; metal ion binding; nucleus; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; Protein phosphatase 2C homolog 2 (PP2C-2) (EC 3.1.3.16) ptc2 SPCC1223.11 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR29177_c1_g2_i1 O15297 PPM1D_HUMAN 4.00E-61 GO:0000086; GO:0046872; GO:0008285; GO:0005634; GO:0035970; GO:0004722; GO:0009617; GO:0009314 P16104; Q00987 G2/M transition of mitotic cell cycle; metal ion binding; negative regulation of cell proliferation; nucleus; peptidyl-threonine dephosphorylation; protein serine/threonine phosphatase activity; response to bacterium; response to radiation IPR001932; IPR000222; IPR015655; Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1) PPM1D WIP1 Homo sapiens (Human) TR29178_c0_g1_i1 Q3T0J1 FBX4_BOVIN 2.00E-45 GO:0019005; GO:0031146; GO:0005737; GO:0031398; GO:0000209; GO:0000723 SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cytoplasm; positive regulation of protein ubiquitination; protein polyubiquitination; telomere maintenance IPR001810; Protein modification; protein ubiquitination. F-box only protein 4 FBXO4 Bos taurus (Bovine) TR29180_c0_g1_i1 Q5TGI0 FAXC_HUMAN 1.00E-48 GO:0016021 integral to membrane IPR026928; IPR010987; IPR012336; Failed axon connections homolog FAXC C6orf168 Homo sapiens (Human) TR29182_c2_g1_i1 Q6PFY8 TRI45_MOUSE 6.00E-16 GO:0060348; GO:0005737; GO:0005634; GO:0008270 bone development; cytoplasm; nucleus; zinc ion binding IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) TR29185_c0_g1_i1 Q63ZI0 KCNK9_XENLA 8.00E-15 GO:0016021; GO:0005267; GO:0005244 integral to membrane; potassium channel activity; voltage-gated ion channel activity IPR003280; IPR013099; IPR003092; IPR005407; Potassium channel subfamily K member 9 kcnk9 Xenopus laevis (African clawed frog) TR29185_c0_g1_i2 Q8R5I0 KCNKF_RAT 2.00E-16 GO:0016021; GO:0005267; GO:0005244 integral to membrane; potassium channel activity; voltage-gated ion channel activity IPR003280; IPR013099; IPR003092; IPR008073; Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (rTASK-5) (TWIK-related acid-sensitive K(+) channel 5) Kcnk15 Task5 Rattus norvegicus (Rat) TR29185_c0_g1_i4 Q9Y257 KCNK6_HUMAN 8.00E-09 GO:0005242; GO:0007268; GO:0008076 inward rectifier potassium channel activity; synaptic transmission; voltage-gated potassium channel complex IPR003280; IPR013099; IPR003092; IPR005408; IPR005409; Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence) KCNK6 TOSS TWIK2 Homo sapiens (Human) TR29185_c0_g1_i5 O54912 KCNK3_RAT 2.00E-21 GO:0007420; GO:0071456; GO:0071294; GO:0090102; GO:0016021; GO:0005252; GO:0005886; GO:0022841; GO:0046982; GO:0042803; GO:0051481; GO:0042493 brain development; cellular response to hypoxia; cellular response to zinc ion; cochlea development; integral to membrane; open rectifier potassium channel activity; plasma membrane; potassium ion leak channel activity; protein heterodimerization activity; protein homodimerization activity; reduction of cytosolic calcium ion concentration; response to drug IPR003280; IPR013099; IPR003092; IPR005406; Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1) (Two pore K(+) channel KT3.1) Kcnk3 Task Task1 Rattus norvegicus (Rat) TR29185_c0_g1_i6 P34410 TWK7_CAEEL 2.00E-22 GO:0016021; GO:0005267 integral to membrane; potassium channel activity IPR003280; IPR013099; IPR003092; TWiK family of potassium channels protein 7 twk-7 twk-8 F22B7.7 Caenorhabditis elegans TR29186_c0_g1_i2 Q5XI37 RT15_RAT 2.00E-10 GO:0005763; GO:0031965; GO:0003735; GO:0006412 mitochondrial small ribosomal subunit; nuclear membrane; structural constituent of ribosome; translation IPR000589; IPR005290; IPR009068; "28S ribosomal protein S15, mitochondrial (MRP-S15) (S15mt)" Mrps15 Rattus norvegicus (Rat) TR29187_c0_g1_i5 Q8BKT8 HAUS7_MOUSE 7.00E-08 GO:0070652; GO:0051301; GO:0005813; GO:0051297; GO:0005737; GO:0005874; GO:0007067; GO:0005730; GO:0005886; GO:0005819; GO:0051225; GO:0031996 HAUS complex; cell division; centrosome; centrosome organization; cytoplasm; microtubule; mitosis; nucleolus; plasma membrane; spindle; spindle assembly; thioesterase binding HAUS augmin-like complex subunit 7 (26S proteasome-associated UCH37-interacting protein 1) (UCHL5-interacting protein) Haus7 Uchl5ip Uip1 Mus musculus (Mouse) TR29196_c6_g1_i1 O75817 POP7_HUMAN 2.00E-35 GO:0005655; GO:0004526; GO:0008033 Q9BUL9; P63162 nucleolar ribonuclease P complex; ribonuclease P activity; tRNA processing IPR014612; Ribonuclease P protein subunit p20 (RNaseP protein p20) (EC 3.1.26.5) (Ribonucleases P/MRP protein subunit POP7 homolog) (hPOP7) POP7 RPP20 Homo sapiens (Human) TR29196_c7_g1_i2 P0A550 DPO1_MYCTU 1.00E-15 GO:0008408; GO:0008409; GO:0003677; GO:0006281; GO:0006260; GO:0003887; GO:0005618; GO:0040007; GO:0090305; GO:0005886 3'-5' exonuclease activity; 5'-3' exonuclease activity; DNA binding; DNA repair; DNA replication; DNA-directed DNA polymerase activity; cell wall; growth; nucleic acid phosphodiester bond hydrolysis; plasma membrane IPR002562; IPR020046; IPR020045; IPR002421; IPR019760; IPR001098; IPR018320; IPR002298; IPR008918; IPR003583; IPR012337; DNA polymerase I (POL I) (EC 2.7.7.7) polA Rv1629 MT1665 MTCY01B2.21 Mycobacterium tuberculosis TR29196_c8_g1_i1 Q7Z5Q5 DPOLN_HUMAN 5.00E-33 GO:0003677; GO:0006281; GO:0006260; GO:0003887; GO:0005634 DNA binding; DNA repair; DNA replication; DNA-directed DNA polymerase activity; nucleus IPR001098; IPR002298; DNA polymerase nu (EC 2.7.7.7) POLN Homo sapiens (Human) TR29198_c0_g1_i1 Q92542 NICA_HUMAN 9.00E-56 GO:0005794; GO:0007220; GO:0007219; GO:0042098; GO:0042987; GO:0097190; GO:0050435; GO:0004175; GO:0005783; GO:0050673; GO:0005887; GO:0005765; GO:0042470; GO:0006509; GO:0031293; GO:0002262; GO:0048011; GO:0043065; GO:0043085; GO:0016485 Q96BI3; P49768; Q9NZ42; P49755 Golgi apparatus; Notch receptor processing; Notch signaling pathway; T cell proliferation; amyloid precursor protein catabolic process; apoptotic signaling pathway; beta-amyloid metabolic process; endopeptidase activity; endoplasmic reticulum; epithelial cell proliferation; integral to plasma membrane; lysosomal membrane; melanosome; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; myeloid cell homeostasis; neurotrophin TRK receptor signaling pathway; positive regulation of apoptotic process; positive regulation of catalytic activity; protein processing IPR008710; Nicastrin NCSTN KIAA0253 UNQ1874/PRO4317 Homo sapiens (Human) TR29198_c0_g1_i2 Q23316 NICA_CAEEL 2.00E-12 GO:0007219; GO:0060581; GO:0048598; GO:0016021; GO:0018991; GO:0060465; GO:0005886; GO:0016485 Notch signaling pathway; cell fate commitment involved in pattern specification; embryonic morphogenesis; integral to membrane; oviposition; pharynx development; plasma membrane; protein processing IPR008710; Nicastrin (Anterior-pharynx-defective protein 2) aph-2 ZC434.6 Caenorhabditis elegans TR29198_c1_g1_i2 Q92542 NICA_HUMAN 4.00E-51 GO:0005794; GO:0007220; GO:0007219; GO:0042098; GO:0042987; GO:0097190; GO:0050435; GO:0004175; GO:0005783; GO:0050673; GO:0005887; GO:0005765; GO:0042470; GO:0006509; GO:0031293; GO:0002262; GO:0048011; GO:0043065; GO:0043085; GO:0016485 Q96BI3; P49768; Q9NZ42; P49755 Golgi apparatus; Notch receptor processing; Notch signaling pathway; T cell proliferation; amyloid precursor protein catabolic process; apoptotic signaling pathway; beta-amyloid metabolic process; endopeptidase activity; endoplasmic reticulum; epithelial cell proliferation; integral to plasma membrane; lysosomal membrane; melanosome; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; myeloid cell homeostasis; neurotrophin TRK receptor signaling pathway; positive regulation of apoptotic process; positive regulation of catalytic activity; protein processing IPR008710; Nicastrin NCSTN KIAA0253 UNQ1874/PRO4317 Homo sapiens (Human) TR29199_c7_g1_i1 A9ULZ2 BIR7B_XENLA 1.00E-15 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) TR29201_c0_g1_i1 Q6XHB2 ROCO4_DICDI 3.00E-08 GO:0005524; GO:0005525; GO:0005829; GO:0004672; GO:0004674; GO:0031153; GO:0007264; GO:0031150 ATP binding; GTP binding; cytosol; protein kinase activity; protein serine/threonine kinase activity; slug development involved in sorocarp development; small GTPase mediated signal transduction; sorocarp stalk development IPR011009; IPR001611; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR001245; IPR015943; IPR001680; IPR017986; Probable serine/threonine-protein kinase roco4 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 4) roco4 DDB_G0288251 Dictyostelium discoideum (Slime mold) TR29203_c1_g1_i1 Q9NFT7 HXK2_DROME 2.00E-111 GO:0005524; GO:0001678; GO:0005829; GO:0008865; GO:0004340; GO:0006096; GO:0019158 ATP binding; cellular glucose homeostasis; cytosol; fructokinase activity; glucokinase activity; glycolysis; mannokinase activity IPR001312; IPR022673; IPR019807; IPR022672; Carbohydrate metabolism; hexose metabolism. Hexokinase type 2 (EC 2.7.1.1) Hex-t2 Hex CG32849 Drosophila melanogaster (Fruit fly) TR29205_c2_g1_i3 Q9NZJ4 SACS_HUMAN 6.00E-23 GO:0005524; GO:0030424; GO:0070852; GO:0008219; GO:0051087; GO:0030425; GO:0005739; GO:0090084; GO:0005634; GO:0006457 ATP binding; axon; cell body fiber; cell death; chaperone binding; dendrite; mitochondrion; negative regulation of inclusion body assembly; nucleus; protein folding IPR001623; IPR003594; IPR007842; IPR000626; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) TR29211_c0_g1_i1 Q862Z3 UROM_CANFA 8.00E-06 GO:0031225; GO:0016324; GO:0016323; GO:0005509; GO:0060170; GO:0005576; GO:0072372; GO:0000922 anchored to membrane; apical plasma membrane; basolateral plasma membrane; calcium ion binding; cilium membrane; extracellular region; primary cilium; spindle pole IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR023413; IPR009030; IPR001507; IPR017977; "Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]" UMOD Canis familiaris (Dog) (Canis lupus familiaris) TR29211_c0_g1_i2 Q91X17 UROM_MOUSE 3.00E-08 GO:0031225; GO:0016324; GO:0016323; GO:0005509; GO:0048878; GO:0060170; GO:0007588; GO:0005576; GO:0072218; GO:0072221; GO:0072233; GO:0072372; GO:2000021; GO:0000922 anchored to membrane; apical plasma membrane; basolateral plasma membrane; calcium ion binding; chemical homeostasis; cilium membrane; excretion; extracellular region; metanephric ascending thin limb development; metanephric distal convoluted tubule development; metanephric thick ascending limb development; primary cilium; regulation of ion homeostasis; spindle pole IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR023413; IPR009030; IPR001507; IPR017977; "Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]" Umod Mus musculus (Mouse) TR29211_c1_g1_i1 Q8N2E2 VWDE_HUMAN 1.00E-10 GO:0005576 extracellular region IPR000742; IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) TR29212_c1_g1_i1 Q13332 PTPRS_HUMAN 6.00E-24 GO:0007155; GO:0021549; GO:0021987; GO:0022038; GO:0030198; GO:0021766; GO:0005887; GO:0021510; GO:0005001 Q16849 cell adhesion; cerebellum development; cerebral cortex development; corpus callosum development; extracellular matrix organization; hippocampus development; integral to plasma membrane; spinal cord development; transmembrane receptor protein tyrosine phosphatase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma) PTPRS Homo sapiens (Human) TR29212_c2_g1_i1 P23471 PTPRZ_HUMAN 9.00E-23 GO:0007409; GO:0007417; GO:0005887; GO:0072534; GO:0008330; GO:0005578; GO:0005001 Q9UM73 axonogenesis; central nervous system development; integral to plasma membrane; perineuronal net; protein tyrosine/threonine phosphatase activity; proteinaceous extracellular matrix; transmembrane receptor protein tyrosine phosphatase activity IPR001148; IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2) PTPRZ1 HTPZP2 PTPRZ PTPRZ2 PTPZ Homo sapiens (Human) TR29212_c2_g1_i4 Q9W6V5 PTPRJ_CHICK 1.00E-24 GO:0005911; GO:0016021; GO:0043407; GO:0050860; GO:0042059; GO:0051898; GO:0035335; GO:0016791; GO:0005886; GO:0048008; GO:0051894; GO:0004725; GO:0032587 cell-cell junction; integral to membrane; negative regulation of MAP kinase activity; negative regulation of T cell receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein kinase B signaling cascade; peptidyl-tyrosine dephosphorylation; phosphatase activity; plasma membrane; platelet-derived growth factor receptor signaling pathway; positive regulation of focal adhesion assembly; protein tyrosine phosphatase activity; ruffle membrane IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (Supporting-cell antigen) PTPRJ Gallus gallus (Chicken) TR29212_c3_g1_i1 Q96GP6 SREC2_HUMAN 1.00E-10 GO:0007157; GO:0016021; GO:0005044 P16333 heterophilic cell-cell adhesion; integral to membrane; scavenger receptor activity IPR000742; IPR013032; IPR002049; IPR009030; Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) TR29212_c3_g2_i1 P59222 SREC2_MOUSE 2.00E-11 GO:0007157; GO:0016021; GO:0005044 heterophilic cell-cell adhesion; integral to membrane; scavenger receptor activity IPR000742; IPR013032; IPR009030; Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) TR29212_c3_g3_i1 Q99M80 PTPRT_MOUSE 3.00E-23 GO:0051393; GO:0045294; GO:0008013; GO:0009986; GO:0007156; GO:0016021; GO:0005886; GO:0004725; GO:0016790; GO:0007169 alpha-actinin binding; alpha-catenin binding; beta-catenin binding; cell surface; homophilic cell adhesion; integral to membrane; plasma membrane; protein tyrosine phosphatase activity; thiolester hydrolase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) TR29212_c3_g4_i1 Q8BUM3 PTN7_MOUSE 2.00E-18 GO:0005856; GO:0005829; GO:0009898; GO:0004725 cytoskeleton; cytosol; internal side of plasma membrane; protein tyrosine phosphatase activity IPR000387; IPR016130; IPR008356; IPR000242; Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Hematopoietic protein-tyrosine phosphatase) (HEPTP) Ptpn7 Mus musculus (Mouse) TR29215_c0_g1_i2 Q78WZ7 RPA43_MOUSE 4.00E-32 GO:0003899; GO:0015630; GO:0005730; GO:0006351 "DNA-directed RNA polymerase activity; microtubule cytoskeleton; nucleolus; transcription, DNA-dependent" IPR005576; DNA-directed RNA polymerase I subunit RPA43 (Twist neighbor protein) Twistnb Mus musculus (Mouse) TR29215_c0_g1_i5 Q3B726 RPA43_HUMAN 1.00E-34 GO:0003899; GO:0015630; GO:0005730; GO:0006351 "DNA-directed RNA polymerase activity; microtubule cytoskeleton; nucleolus; transcription, DNA-dependent" IPR005576; DNA-directed RNA polymerase I subunit RPA43 (Twist neighbor protein) TWISTNB Homo sapiens (Human) TR29217_c1_g1_i4 D3ZFW5 TM107_RAT 2.00E-37 GO:0042384; GO:0016021 cilium assembly; integral to membrane Transmembrane protein 107 Tmem107 Rattus norvegicus (Rat) TR29219_c0_g1_i1 Q8N531 FBXL6_HUMAN 1.00E-28 GO:0006508; GO:0004842 proteolysis; ubiquitin-protein ligase activity IPR001810; F-box/LRR-repeat protein 6 (F-box and leucine-rich repeat protein 6) (F-box protein FBL6) (FBL6A) FBXL6 FBL6 Homo sapiens (Human) TR29219_c0_g2_i1 Q9M0U9 SKI19_ARATH 1.00E-10 GO:0005634; GO:0016567 nucleus; protein ubiquitination IPR001810; IPR001611; Protein modification; protein ubiquitination. F-box protein SKIP19 (F-box/LRR-repeat protein 20) (SKP1-interacting partner 19) SKIP19 FBL20 At4g05460 C6L9.140 Arabidopsis thaliana (Mouse-ear cress) TR29220_c1_g1_i1 Q1LZ71 LFG2_BOVIN 8.00E-60 GO:0006915; GO:0030054; GO:0021702; GO:0021681; GO:0016021; GO:0045121; GO:0045211; GO:0043523 apoptotic process; cell junction; cerebellar Purkinje cell differentiation; cerebellar granular layer development; integral to membrane; membrane raft; postsynaptic membrane; regulation of neuron apoptotic process IPR006214; Protein lifeguard 2 (Fas apoptotic inhibitory molecule 2) FAIM2 LFG2 Bos taurus (Bovine) TR29222_c0_g1_i1 P78318 IGBP1_HUMAN 2.00E-52 GO:0042113; GO:0005737; GO:0043066; GO:0043154; GO:0035308; GO:0032873; GO:0000122; GO:0035306; GO:0045944; GO:0008601; GO:0060632; GO:0070555; GO:0034612; GO:0007165 P67775; P62714; P60510; O00743; O75663 B cell activation; cytoplasm; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of protein dephosphorylation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; positive regulation of dephosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein phosphatase type 2A regulator activity; regulation of microtubule-based movement; response to interleukin-1; response to tumor necrosis factor; signal transduction IPR007304; Immunoglobulin-binding protein 1 (B-cell signal transduction molecule alpha 4) (Protein alpha-4) (CD79a-binding protein 1) (Protein phosphatase 2/4/6 regulatory subunit) (Renal carcinoma antigen NY-REN-16) IGBP1 IBP1 Homo sapiens (Human) TR29225_c0_g1_i2 P10155 RO60_HUMAN 2.00E-19 GO:0003723; GO:0060271; GO:0005737; GO:0046872; GO:0005634; GO:0030529; GO:0006383 Q9UHX1 RNA binding; cilium morphogenesis; cytoplasm; metal ion binding; nucleus; ribonucleoprotein complex; transcription from RNA polymerase III promoter IPR008858; IPR018698; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) TR29225_c0_g1_i7 Q9RUW8 RO60_DEIRA 7.00E-06 GO:0003723; GO:0005737; GO:0046872; GO:0030529 RNA binding; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein homolog (Ro sixty-related protein) rsr DR_1262 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) TR29225_c0_g1_i8 O08848 RO60_MOUSE 1.00E-19 GO:0003723; GO:0060271; GO:0005737; GO:0046872; GO:0030529 RNA binding; cilium morphogenesis; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) Trove2 Ssa2 Mus musculus (Mouse) TR29226_c0_g1_i1 Q8R151 ZNFX1_MOUSE 4.00E-71 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR29227_c1_g1_i1 Q29042 FCN1_PIG 3.00E-51 GO:0005581; GO:0045087; GO:0046872 collagen; innate immune response; metal ion binding IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Ficolin-A) (Ficolin-alpha) FCN1 Sus scrofa (Pig) TR29227_c1_g1_i2 Q9WTS8 FCN1_RAT 1.00E-45 GO:0005581; GO:0045087; GO:0046872 collagen; innate immune response; metal ion binding IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) Fcn1 Fcna Rattus norvegicus (Rat) TR29227_c1_g1_i4 Q29042 FCN1_PIG 4.00E-49 GO:0005581; GO:0045087; GO:0046872 collagen; innate immune response; metal ion binding IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Ficolin-A) (Ficolin-alpha) FCN1 Sus scrofa (Pig) TR29229_c0_g1_i1 P17678 GATA1_CHICK 5.00E-54 GO:0005634; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR000679; IPR013088; Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (NF-E1 DNA-binding protein) (NF-E1a) GATA1 ERYF1 Gallus gallus (Chicken) TR29229_c0_g1_i2 P23824 GATA2_CHICK 3.00E-75 GO:0001077; GO:0000980; GO:0021533; GO:0001709; GO:0048469; GO:0021954; GO:0003682; GO:0060216; GO:0001892; GO:0035854; GO:0048873; GO:0042472; GO:0045746; GO:0045599; GO:0070345; GO:0045650; GO:2000178; GO:0000122; GO:0048663; GO:0005634; GO:0021983; GO:0045766; GO:0045648; GO:0045654; GO:0043234; GO:0035065; GO:0060872; GO:0035019; GO:0001655; GO:0021514; GO:0008270 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II distal enhancer sequence-specific DNA binding; cell differentiation in hindbrain; cell fate determination; cell maturation; central nervous system neuron development; chromatin binding; definitive hemopoiesis; embryonic placenta development; eosinophil fate commitment; homeostasis of number of cells within a tissue; inner ear morphogenesis; negative regulation of Notch signaling pathway; negative regulation of fat cell differentiation; negative regulation of fat cell proliferation; negative regulation of macrophage differentiation; negative regulation of neural precursor cell proliferation; negative regulation of transcription from RNA polymerase II promoter; neuron fate commitment; nucleus; pituitary gland development; positive regulation of angiogenesis; positive regulation of erythrocyte differentiation; positive regulation of megakaryocyte differentiation; protein complex; regulation of histone acetylation; semicircular canal development; somatic stem cell maintenance; urogenital system development; ventral spinal cord interneuron differentiation; zinc ion binding IPR016374; IPR000679; IPR013088; GATA-binding factor 2 (GATA-2) (Transcription factor NF-E1b) GATA2 Gallus gallus (Chicken) TR29229_c0_g1_i4 P23824 GATA2_CHICK 6.00E-75 GO:0001077; GO:0000980; GO:0021533; GO:0001709; GO:0048469; GO:0021954; GO:0003682; GO:0060216; GO:0001892; GO:0035854; GO:0048873; GO:0042472; GO:0045746; GO:0045599; GO:0070345; GO:0045650; GO:2000178; GO:0000122; GO:0048663; GO:0005634; GO:0021983; GO:0045766; GO:0045648; GO:0045654; GO:0043234; GO:0035065; GO:0060872; GO:0035019; GO:0001655; GO:0021514; GO:0008270 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II distal enhancer sequence-specific DNA binding; cell differentiation in hindbrain; cell fate determination; cell maturation; central nervous system neuron development; chromatin binding; definitive hemopoiesis; embryonic placenta development; eosinophil fate commitment; homeostasis of number of cells within a tissue; inner ear morphogenesis; negative regulation of Notch signaling pathway; negative regulation of fat cell differentiation; negative regulation of fat cell proliferation; negative regulation of macrophage differentiation; negative regulation of neural precursor cell proliferation; negative regulation of transcription from RNA polymerase II promoter; neuron fate commitment; nucleus; pituitary gland development; positive regulation of angiogenesis; positive regulation of erythrocyte differentiation; positive regulation of megakaryocyte differentiation; protein complex; regulation of histone acetylation; semicircular canal development; somatic stem cell maintenance; urogenital system development; ventral spinal cord interneuron differentiation; zinc ion binding IPR016374; IPR000679; IPR013088; GATA-binding factor 2 (GATA-2) (Transcription factor NF-E1b) GATA2 Gallus gallus (Chicken) TR29230_c2_g1_i1 P35622 TNNC_MIZYE 4.00E-55 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Troponin C (TN-C) Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) TR29230_c2_g1_i2 Q9BLG0 TNNC_TODPA 2.00E-56 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Troponin C (TN-C) Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus) TR29231_c4_g2_i1 Q568B7 GTDC1_DANRE 1.00E-32 GO:0009058; GO:0016757 "biosynthetic process; transferase activity, transferring glycosyl groups" IPR001296; IPR022701; Glycosyltransferase-like domain-containing protein 1 gtdc1 si:dkey-52o2.3 zgc:110568 Danio rerio (Zebrafish) (Brachydanio rerio) TR29232_c0_g1_i1 Q24423 NOC_DROME 9.00E-21 GO:0003677; GO:0007219; GO:0007420; GO:0008283; GO:0002121; GO:0035218; GO:0046872; GO:0010629; GO:0005634; GO:0008056; GO:0006357; GO:0007430; GO:0035220 Q9W512; Q9V3G9 "DNA binding; Notch signaling pathway; brain development; cell proliferation; inter-male aggressive behavior; leg disc development; metal ion binding; negative regulation of gene expression; nucleus; ocellus development; regulation of transcription from RNA polymerase II promoter; terminal branching, open tracheal system; wing disc development" IPR007087; IPR015880; IPR013087; Zinc finger protein Noc (Zinc finger protein NocA) noc nocA CG4491 Drosophila melanogaster (Fruit fly) TR29236_c6_g3_i2 Q9CQT9 CT024_MOUSE 5.00E-32 GO:0005739 mitochondrion IPR010742; Uncharacterized protein C20orf24 homolog Mus musculus (Mouse) TR29237_c0_g2_i1 Q99590 SCAFB_HUMAN 9.00E-10 GO:0005634; GO:0000245; GO:0008270 nucleus; spliceosomal complex assembly; zinc ion binding IPR001841; IPR013083; IPR017907; "Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129)" SCAF11 CASP11 SFRS2IP SIP1 SRSF2IP Homo sapiens (Human) TR29237_c0_g3_i1 A6H619 PHRF1_MOUSE 8.00E-29 GO:0070063; GO:0035556; GO:0006397; GO:0006366; GO:0008270 RNA polymerase binding; intracellular signal transduction; mRNA processing; transcription from RNA polymerase II promoter; zinc ion binding IPR002219; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; PHD and RING finger domain-containing protein 1 Phrf1 Kiaa1542 Mus musculus (Mouse) TR29238_c0_g1_i1 Q8N264 RHG24_HUMAN 1.00E-86 GO:0030675; GO:0032863; GO:0001525; GO:0030154; GO:0042995; GO:0005856; GO:0005829; GO:0005925; GO:0035021; GO:1900028; GO:0005543; GO:0005886; GO:0051056; GO:0007264; GO:0035313 P21333 "Rac GTPase activator activity; activation of Rac GTPase activity; angiogenesis; cell differentiation; cell projection; cytoskeleton; cytosol; focal adhesion; negative regulation of Rac protein signal transduction; negative regulation of ruffle assembly; phospholipid binding; plasma membrane; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; wound healing, spreading of epidermal cells" IPR011993; IPR001849; IPR008936; IPR000198; Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) ARHGAP24 FILGAP Homo sapiens (Human) TR29238_c0_g1_i4 O08967 CYH3_MOUSE 1.00E-11 GO:0005086; GO:0005737; GO:0090162; GO:0005547; GO:0005886; GO:0045785; GO:0032012; GO:0001726 "ARF guanyl-nucleotide exchange factor activity; cytoplasm; establishment of epithelial cell polarity; phosphatidylinositol-3,4,5-trisphosphate binding; plasma membrane; positive regulation of cell adhesion; regulation of ARF protein signal transduction; ruffle" IPR011993; IPR001849; IPR023394; IPR000904; "Cytohesin-3 (ARF nucleotide-binding site opener 3) (Protein ARNO3) (General receptor of phosphoinositides 1) (Grp1) (PH, SEC7 and coiled-coil domain-containing protein 3) (CLM3) (SEC7 homolog C) (mSec7-3)" Cyth3 Grp1 Pscd3 Mus musculus (Mouse) TR29239_c0_g1_i1 Q5D144 TFAM_PIG 3.00E-10 GO:0008301; GO:0003682; GO:0070363; GO:0042645; GO:0033108; GO:0045893; GO:0003700; GO:0006391 "DNA binding, bending; chromatin binding; mitochondrial light strand promoter sense binding; mitochondrial nucleoid; mitochondrial respiratory chain complex assembly; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription initiation from mitochondrial promoter" IPR009071; "Transcription factor A, mitochondrial (mtTFA)" TFAM Sus scrofa (Pig) TR29239_c0_g1_i3 Q5D144 TFAM_PIG 3.00E-10 GO:0008301; GO:0003682; GO:0070363; GO:0042645; GO:0033108; GO:0045893; GO:0003700; GO:0006391 "DNA binding, bending; chromatin binding; mitochondrial light strand promoter sense binding; mitochondrial nucleoid; mitochondrial respiratory chain complex assembly; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription initiation from mitochondrial promoter" IPR009071; "Transcription factor A, mitochondrial (mtTFA)" TFAM Sus scrofa (Pig) TR29239_c0_g1_i4 Q32L34 HMGB4_BOVIN 8.00E-06 GO:0003677; GO:0005694; GO:0005634 DNA binding; chromosome; nucleus IPR009071; High mobility group protein B4 HMGB4 Bos taurus (Bovine) TR29241_c1_g1_i1 O15550 KDM6A_HUMAN 7.00E-122 GO:0000978; GO:0060070; GO:0051213; GO:0007507; GO:0051568; GO:0071558; GO:0035097; GO:0001701; GO:0048333; GO:0046872; GO:0001843; GO:0048570; GO:0003016; GO:0032525 RNA polymerase II core promoter proximal region sequence-specific DNA binding; canonical Wnt receptor signaling pathway; dioxygenase activity; heart development; histone H3-K4 methylation; histone demethylase activity (H3-K27 specific); histone methyltransferase complex; in utero embryonic development; mesodermal cell differentiation; metal ion binding; neural tube closure; notochord morphogenesis; respiratory system process; somite rostral/caudal axis specification IPR003347; IPR013026; IPR011990; IPR001440; IPR019734; Lysine-specific demethylase 6A (EC 1.14.11.-) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) KDM6A UTX Homo sapiens (Human) TR29243_c0_g3_i1 Q13702 RAPSN_HUMAN 8.00E-60 GO:0005794; GO:0033130; GO:0030054; GO:0005737; GO:0005856; GO:0031594; GO:0005886; GO:0043525; GO:0045211; GO:0007271; GO:0008270 "Golgi apparatus; acetylcholine receptor binding; cell junction; cytoplasm; cytoskeleton; neuromuscular junction; plasma membrane; positive regulation of neuron apoptotic process; postsynaptic membrane; synaptic transmission, cholinergic; zinc ion binding" IPR001237; IPR018293; IPR019568; IPR013026; IPR011990; IPR001440; IPR019734; IPR001841; IPR013083; 43 kDa receptor-associated protein of the synapse (RAPsyn) (43 kDa postsynaptic protein) (Acetylcholine receptor-associated 43 kDa protein) (RING finger protein 205) RAPSN RNF205 Homo sapiens (Human) TR29244_c0_g5_i1 P35659 DEK_HUMAN 2.00E-22 GO:0003677; GO:0016568; GO:0042393; GO:0005634; GO:2000779; GO:2001032; GO:0006357; GO:0007165; GO:0006366; GO:0019079 DNA binding; chromatin modification; histone binding; nucleus; regulation of double-strand break repair; regulation of double-strand break repair via nonhomologous end joining; regulation of transcription from RNA polymerase II promoter; signal transduction; transcription from RNA polymerase II promoter; viral genome replication IPR014876; IPR009057; IPR003034; Protein DEK DEK Homo sapiens (Human) TR29250_c3_g1_i1 P89116 CASP1_SPOFR 3.00E-36 GO:0006915; GO:0004197; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-1 (EC 3.4.22.-) [Cleaved into: Caspase-1 subunit p19/18; Caspase-1 subunit p12] Spodoptera frugiperda (Fall armyworm) TR29250_c3_g1_i2 Q8MJC3 CASP3_RABIT 2.00E-42 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Oryctolagus cuniculus (Rabbit) TR29250_c3_g1_i5 O08738 CASP6_MOUSE 1.00E-32 GO:0006915; GO:0004197; GO:0005829; GO:0005634; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytosol; nucleus; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11] Casp6 Mus musculus (Mouse) TR29253_c1_g1_i1 P77735 YAJO_ECOLI 2.00E-51 GO:0016491; GO:0006772 oxidoreductase activity; thiamine metabolic process IPR001395; IPR020471; IPR023210; Uncharacterized oxidoreductase YajO (EC 1.-.-.-) yajO b0419 JW0409 Escherichia coli (strain K12) TR29255_c0_g1_i2 P18172 DHGL_DROPS 2.00E-37 GO:0006066; GO:0008812; GO:0005576; GO:0050660 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR29255_c0_g1_i4 Q1RFM3 BETA_ECOUT 2.00E-24 GO:0008802; GO:0008812; GO:0050660; GO:0019285 betaine-aldehyde dehydrogenase activity; choline dehydrogenase activity; flavin adenine dinucleotide binding; glycine betaine biosynthetic process from choline IPR011533; IPR012132; IPR000172; IPR007867; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. Oxygen-dependent choline dehydrogenase (CDH) (CHD) (EC 1.1.99.1) (Betaine aldehyde dehydrogenase) (BADH) (EC 1.2.1.8) betA UTI89_C0340 Escherichia coli (strain UTI89 / UPEC) TR29260_c1_g1_i1 Q8BHC1 RB39B_MOUSE 6.00E-79 GO:0005525; GO:0005794; GO:0005886; GO:0015031; GO:0007264; GO:0050808; GO:0016192 GTP binding; Golgi apparatus; plasma membrane; protein transport; small GTPase mediated signal transduction; synapse organization; vesicle-mediated transport IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-39B Rab39b Mus musculus (Mouse) TR29262_c2_g1_i1 Q9HBM0 VEZA_HUMAN 4.00E-08 GO:0001669; GO:0005912; GO:0016337; GO:0043009; GO:0016021; GO:0005634; GO:0005886; GO:0002142 acrosomal vesicle; adherens junction; cell-cell adhesion; chordate embryonic development; integral to membrane; nucleus; plasma membrane; stereocilia ankle link complex IPR026859; IPR026858; Vezatin VEZT Homo sapiens (Human) TR29263_c0_g2_i1 Q29RU9 SOX_BOVIN 4.00E-124 GO:0033514; GO:0050031; GO:0005777; GO:0008115; GO:0046653 L-lysine catabolic process to acetyl-CoA via L-pipecolate; L-pipecolate oxidase activity; peroxisome; sarcosine oxidase activity; tetrahydrofolate metabolic process IPR006076; IPR006281; Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase) PIPOX Bos taurus (Bovine) TR29265_c5_g1_i1 Q9V4A7 PLXB_DROME 7.00E-27 GO:0016021; GO:0005622; GO:0008045; GO:0035021; GO:0005886; GO:0035025; GO:0004872; GO:0007165 integral to membrane; intracellular; motor neuron axon guidance; negative regulation of Rac protein signal transduction; plasma membrane; positive regulation of Rho protein signal transduction; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-B plexB CG17245 Drosophila melanogaster (Fruit fly) TR29265_c5_g1_i2 O45657 PLX2_CAEEL 5.00E-13 GO:0030154; GO:0031252; GO:0009986; GO:0009792; GO:0016021; GO:0005622; GO:0002119; GO:0005886; GO:0004872; GO:0007165; GO:0045138 cell differentiation; cell leading edge; cell surface; embryo development ending in birth or egg hatching; integral to membrane; intracellular; nematode larval development; plasma membrane; receptor activity; signal transduction; tail tip morphogenesis IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-2 plx-2 K04B12.1 Caenorhabditis elegans TR29265_c5_g1_i4 Q9V4A7 PLXB_DROME 5.00E-28 GO:0016021; GO:0005622; GO:0008045; GO:0035021; GO:0005886; GO:0035025; GO:0004872; GO:0007165 integral to membrane; intracellular; motor neuron axon guidance; negative regulation of Rac protein signal transduction; plasma membrane; positive regulation of Rho protein signal transduction; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-B plexB CG17245 Drosophila melanogaster (Fruit fly) TR29267_c1_g1_i1 Q20363 SIP1_CAEEL 2.00E-09 GO:0008340 determination of adult lifespan IPR002068; IPR001436; IPR008978; Stress-induced protein 1 sip-1 F43D9.4 Caenorhabditis elegans TR29267_c1_g1_i2 P12812 P40_SCHMA 1.00E-07 IPR002068; IPR001436; IPR008978; Major egg antigen (p40) Schistosoma mansoni (Blood fluke) TR29268_c1_g1_i1 P45200 Y1430_HAEIN 1.00E-10 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Probable NADP-dependent dehydrogenase HI_1430 (EC 1.1.1.-) HI_1430 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) TR29268_c1_g1_i2 O86034 BDHA_RHIME 7.00E-59 GO:0003858 3-hydroxybutyrate dehydrogenase activity IPR011294; IPR002198; IPR002347; IPR016040; IPR020904; D-beta-hydroxybutyrate dehydrogenase (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (3-HBDH) bdhA RB1136 SMb21010 Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) TR29270_c0_g1_i2 O16025 AOSL_PLEHO 1.00E-22 GO:0047677; GO:0019369; GO:0004096; GO:0005737; GO:0020037; GO:0047987; GO:0005506; GO:0016020; GO:0031408 arachidonate 8(R)-lipoxygenase activity; arachidonic acid metabolic process; catalase activity; cytoplasm; heme binding; hydroperoxide dehydratase activity; iron ion binding; membrane; oxylipin biosynthetic process IPR020835; IPR011614; IPR008976; IPR000907; IPR013819; IPR020834; IPR020833; IPR001885; IPR001024; Lipid metabolism; arachidonate metabolism. Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (EC 4.2.1.92) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)] Plexaura homomalla (Black sea rod) TR29271_c4_g1_i1 Q9Y6R7 FCGBP_HUMAN 5.00E-07 GO:0005737; GO:0005576 cytoplasm; extracellular region IPR003645; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) TR29271_c5_g1_i1 Q9D1H9 MFAP4_MOUSE 2.00E-38 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR014716; IPR014715; IPR002181; Microfibril-associated glycoprotein 4 Mfap4 Mus musculus (Mouse) TR29272_c1_g2_i1 Q08013 SSRG_RAT 7.00E-61 GO:0005784; GO:0006613; GO:0030176 Sec61 translocon complex; cotranslational protein targeting to membrane; integral to endoplasmic reticulum membrane IPR009779; Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma) Ssr3 Rattus norvegicus (Rat) TR29273_c1_g1_i2 Q17Q97 CS060_BOVIN 6.00E-14 Uncharacterized protein C19orf60 homolog Bos taurus (Bovine) TR29277_c0_g1_i1 Q9VJ33 NEDD8_DROME 9.00E-32 GO:0008283; GO:0048812; GO:0005634; GO:0045116; GO:0031386; GO:0031647; GO:0030162; GO:0008589; GO:0051438; GO:0030431 cell proliferation; neuron projection morphogenesis; nucleus; protein neddylation; protein tag; regulation of protein stability; regulation of proteolysis; regulation of smoothened signaling pathway; regulation of ubiquitin-protein ligase activity; sleep IPR019956; IPR019954; IPR000626; NEDD8 (Neddylin) (Ubiquitin-like protein Nedd8) Nedd8 CG10679 Drosophila melanogaster (Fruit fly) TR29279_c4_g1_i1 Q86WC6 PPR27_HUMAN 4.00E-08 GO:0010923; GO:0019902; GO:0004864 P62136 negative regulation of phosphatase activity; phosphatase binding; protein phosphatase inhibitor activity IPR002110; IPR020683; Protein phosphatase 1 regulatory subunit 27 (Dysferlin-interacting protein 1) (Toonin) PPP1R27 DYSFIP1 Homo sapiens (Human) TR29279_c4_g1_i2 F1N6G5 HACE1_BOVIN 1.00E-19 GO:0032580; GO:0000139; GO:0007030; GO:0017137; GO:0007049; GO:0005783; GO:0061025; GO:0070936; GO:0042787; GO:0030334; GO:0006355; GO:0006351; GO:0004842 "Golgi cisterna membrane; Golgi membrane; Golgi organization; Rab GTPase binding; cell cycle; endoplasmic reticulum; membrane fusion; protein K48-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of cell migration; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity" IPR002110; IPR020683; IPR000569; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HACE1 (EC 6.3.2.-) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) HACE1 Bos taurus (Bovine) TR29279_c4_g2_i1 Q4V869 ACBD6_XENLA 1.00E-07 GO:0005737; GO:0000062; GO:0008289 cytoplasm; fatty-acyl-CoA binding; lipid binding IPR000582; IPR002110; IPR020683; IPR014352; Acyl-CoA-binding domain-containing protein 6 acbd6 Xenopus laevis (African clawed frog) TR29280_c0_g1_i1 Q8CH62 ORAV1_MOUSE 2.00E-16 IPR019191; Oral cancer-overexpressed protein 1 homolog Oraov1 Mus musculus (Mouse) TR29281_c1_g1_i1 Q9JLA3 UGGG1_RAT 2.00E-118 GO:0051084; GO:0003980; GO:0005788; GO:0005793; GO:0006486; GO:0051082 'de novo' posttranslational protein folding; UDP-glucose:glycoprotein glucosyltransferase activity; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment; protein glycosylation; unfolded protein binding IPR009448; Protein modification; protein glycosylation. UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (rUGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1) Uggt1 Gt Ugcgl1 Uggt Ugt1 Ugtr Rattus norvegicus (Rat) TR29281_c2_g1_i1 Q8T191 UGGG_DICDI 1.00E-08 GO:0003980; GO:0097359; GO:0005788; GO:0005793; GO:0006486; GO:0030587 UDP-glucose:glycoprotein glucosyltransferase activity; UDP-glucosylation; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment; protein glycosylation; sorocarp development IPR002495; IPR009448; Protein modification; protein glycosylation. Probable UDP-glucose:glycoprotein glucosyltransferase A (EC 2.4.1.-) (Developmental gene 1109 protein) ggtA DG1109 DDB_G0274103 Dictyostelium discoideum (Slime mold) TR29283_c0_g1_i1 P40851 AXL1_YEAST 4.00E-35 GO:0007120; GO:0005935; GO:0043332; GO:0046872; GO:0004222; GO:0007323; GO:0006508 axial cellular bud site selection; cellular bud neck; mating projection tip; metal ion binding; metalloendopeptidase activity; peptide pheromone maturation; proteolysis IPR011249; IPR011237; IPR011765; IPR001431; IPR007863; Putative protease AXL1 (EC 3.4.24.-) AXL1 YPR122W P9642.4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR29283_c0_g1_i3 P35559 IDE_RAT 4.00E-157 GO:0005524; GO:0016887; GO:0001540; GO:0050435; GO:0031626; GO:0010815; GO:0009986; GO:0031597; GO:0008340; GO:0005615; GO:0042447; GO:0043559; GO:1901143; GO:0004222; GO:0005739; GO:0045861; GO:0005634; GO:0005782; GO:0005886; GO:0032461; GO:0051291; GO:0042803; GO:0051289; GO:0051603; GO:0010992; GO:0008270 ATP binding; ATPase activity; beta-amyloid binding; beta-amyloid metabolic process; beta-endorphin binding; bradykinin catabolic process; cell surface; cytosolic proteasome complex; determination of adult lifespan; extracellular space; hormone catabolic process; insulin binding; insulin catabolic process; metalloendopeptidase activity; mitochondrion; negative regulation of proteolysis; nucleus; peroxisomal matrix; plasma membrane; positive regulation of protein oligomerization; protein heterooligomerization; protein homodimerization activity; protein homotetramerization; proteolysis involved in cellular protein catabolic process; ubiquitin homeostasis; zinc ion binding IPR011249; IPR011237; IPR011765; IPR001431; IPR007863; Insulin-degrading enzyme (EC 3.4.24.56) (Insulin protease) (Insulinase) (Insulysin) Ide Rattus norvegicus (Rat) TR29285_c3_g2_i2 Q9QZ73 DCNL1_MOUSE 3.00E-107 GO:0000151 ubiquitin ligase complex IPR014764; IPR005176; IPR009060; DCN1-like protein 1 (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Testis-specific protein 3) Dcun1d1 Dcun1l1 Rp42 Tes3 Mus musculus (Mouse) TR29285_c3_g2_i3 Q96GG9 DCNL1_HUMAN 3.00E-91 GO:0000151 ubiquitin ligase complex IPR014764; IPR005176; IPR009060; DCN1-like protein 1 (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene) DCUN1D1 DCUN1L1 RP42 SCCRO Homo sapiens (Human) TR29286_c0_g1_i1 P05990 PYR1_DROME 0 GO:0044205; GO:0006207; GO:0005524; GO:0016597; GO:0004070; GO:0070409; GO:0004088; GO:0005737; GO:0004151; GO:0006543; GO:0006541; GO:0046872 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; ATP binding; amino acid binding; aspartate carbamoyltransferase activity; carbamoyl phosphate biosynthetic process; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; cytoplasm; dihydroorotase activity; glutamine catabolic process; glutamine metabolic process; metal ion binding IPR006680; IPR006132; IPR006130; IPR002082; IPR006131; IPR011761; IPR013815; IPR013816; IPR006275; IPR005481; IPR005480; IPR006274; IPR002474; IPR005479; IPR005483; IPR002195; IPR017926; IPR011059; IPR011607; IPR016185; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. CAD protein (Protein rudimentary) [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] r CG18572 Drosophila melanogaster (Fruit fly) TR29286_c0_g1_i3 Q91437 PYR1_SQUAC 0 GO:0044205; GO:0006207; GO:0005524; GO:0016597; GO:0004070; GO:0070409; GO:0004088; GO:0005737; GO:0004151; GO:0006543; GO:0046872 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; ATP binding; amino acid binding; aspartate carbamoyltransferase activity; carbamoyl phosphate biosynthetic process; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; cytoplasm; dihydroorotase activity; glutamine catabolic process; metal ion binding IPR006680; IPR006132; IPR006130; IPR002082; IPR006131; IPR011761; IPR013815; IPR013816; IPR006275; IPR005481; IPR005480; IPR006274; IPR002474; IPR005479; IPR005483; IPR002195; IPR017926; IPR011059; IPR011607; IPR016185; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] CAD Squalus acanthias (Spiny dogfish) TR29291_c1_g1_i2 Q8MZC4 CRLS1_DROME 1.00E-53 GO:0006754; GO:0017169; GO:0008808; GO:0016021; GO:0005743; GO:0007006; GO:0008654 ATP biosynthetic process; CDP-alcohol phosphatidyltransferase activity; cardiolipin synthase activity; integral to membrane; mitochondrial inner membrane; mitochondrial membrane organization; phospholipid biosynthetic process IPR000462; Probable cardiolipin synthase (CLS) (EC 2.7.8.-) CLS CG4774 Drosophila melanogaster (Fruit fly) TR29291_c1_g1_i3 O01916 CRLS1_CAEEL 2.00E-40 GO:0032049; GO:0008808; GO:0016021; GO:0005743; GO:0005739; GO:0042127; GO:0051881 cardiolipin biosynthetic process; cardiolipin synthase activity; integral to membrane; mitochondrial inner membrane; mitochondrion; regulation of cell proliferation; regulation of mitochondrial membrane potential IPR000462; Probable cardiolipin synthase 1 (CLS) (EC 2.7.8.-) crls-1 F23H11.9 Caenorhabditis elegans TR29291_c1_g1_i4 Q8MZC4 CRLS1_DROME 4.00E-54 GO:0006754; GO:0017169; GO:0008808; GO:0016021; GO:0005743; GO:0007006; GO:0008654 ATP biosynthetic process; CDP-alcohol phosphatidyltransferase activity; cardiolipin synthase activity; integral to membrane; mitochondrial inner membrane; mitochondrial membrane organization; phospholipid biosynthetic process IPR000462; Probable cardiolipin synthase (CLS) (EC 2.7.8.-) CLS CG4774 Drosophila melanogaster (Fruit fly) TR29292_c0_g3_i1 Q06AU4 RAB34_PIG 2.00E-90 GO:0005525; GO:0005794; GO:0045335; GO:0030670; GO:0090385; GO:0015031; GO:0007264 GTP binding; Golgi apparatus; phagocytic vesicle; phagocytic vesicle membrane; phagosome-lysosome fusion; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-34 RAB34 Sus scrofa (Pig) TR29292_c0_g3_i3 P10536 RAB1B_RAT 1.00E-32 GO:0005525; GO:0005737; GO:0016020; GO:0015031; GO:0007264 GTP binding; cytoplasm; membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-1B Rab1b Rattus norvegicus (Rat) TR29296_c3_g1_i1 P98192 GNPAT_MOUSE 1.00E-37 GO:0021587; GO:0008611; GO:0016287; GO:0006650; GO:0061024; GO:0005739; GO:0016290; GO:0030913; GO:0005782; GO:0005778; GO:0042493; GO:0070542; GO:0007584; GO:0042594; GO:0007416 cerebellum morphogenesis; ether lipid biosynthetic process; glycerone-phosphate O-acyltransferase activity; glycerophospholipid metabolic process; membrane organization; mitochondrion; palmitoyl-CoA hydrolase activity; paranodal junction assembly; peroxisomal matrix; peroxisomal membrane; response to drug; response to fatty acid; response to nutrient; response to starvation; synapse assembly IPR028353; IPR022284; IPR002123; Membrane lipid metabolism; glycerophospholipid metabolism. Dihydroxyacetone phosphate acyltransferase (DAP-AT) (DHAP-AT) (EC 2.3.1.42) (Acyl-CoA:dihydroxyacetonephosphateacyltransferase) (Glycerone-phosphate O-acyltransferase) Gnpat Dhapat Mus musculus (Mouse) TR29296_c7_g1_i1 A4IF87 GNPAT_BOVIN 8.00E-56 GO:0016287; GO:0006650; GO:0005778 glycerone-phosphate O-acyltransferase activity; glycerophospholipid metabolic process; peroxisomal membrane IPR022284; IPR002123; Membrane lipid metabolism; glycerophospholipid metabolism. Dihydroxyacetone phosphate acyltransferase (DAP-AT) (DHAP-AT) (EC 2.3.1.42) (Acyl-CoA:dihydroxyacetonephosphateacyltransferase) (Glycerone-phosphate O-acyltransferase) GNPAT Bos taurus (Bovine) TR29299_c1_g1_i1 Q9ULR3 PPM1H_HUMAN 6.00E-47 GO:0008152; GO:0004721 metabolic process; phosphoprotein phosphatase activity IPR001932; IPR015655; Protein phosphatase 1H (EC 3.1.3.16) PPM1H ARHCL1 KIAA1157 URCC2 Homo sapiens (Human) TR29299_c2_g1_i2 Q28DF4 PPM1H_XENTR 1.00E-52 GO:0008152; GO:0004721 metabolic process; phosphoprotein phosphatase activity IPR001932; IPR015655; Protein phosphatase 1H (EC 3.1.3.16) ppm1h TEgg016i20.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR2930_c0_g1_i1 Q9VCA2 ORCT_DROME 2.00E-08 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR29302_c0_g2_i1 Q19673 TYR3_CAEEL 2.00E-38 GO:0046872; GO:0004497 metal ion binding; monooxygenase activity IPR003582; IPR002227; IPR008922; Putative tyrosinase-like protein tyr-3 tyr-3 F21C3.2 Caenorhabditis elegans TR29303_c0_g1_i1 Q8CB67 LRP11_MOUSE 2.00E-11 GO:0006897; GO:0016021 endocytosis; integral to membrane IPR023415; IPR002172; IPR013980; IPR011106; IPR022409; IPR000601; Low-density lipoprotein receptor-related protein 11 (LRP-11) Lrp11 Mus musculus (Mouse) TR29303_c0_g1_i2 Q5VV43 K0319_HUMAN 3.00E-99 GO:0005769; GO:0031901; GO:0016021; GO:2000171; GO:0001764; GO:0005886 early endosome; early endosome membrane; integral to membrane; negative regulation of dendrite development; neuron migration; plasma membrane IPR003961; IPR013980; IPR011106; IPR022409; IPR002859; IPR000601; Dyslexia-associated protein KIAA0319 KIAA0319 Homo sapiens (Human) TR29307_c0_g1_i1 Q6GL69 MK67I_XENTR 8.00E-39 GO:0003723; GO:0010923; GO:0005730; GO:0000166 RNA binding; negative regulation of phosphatase activity; nucleolus; nucleotide binding IPR021043; IPR012677; IPR000504; MKI67 FHA domain-interacting nucleolar phosphoprotein-like nifk mki67ipl Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR29308_c0_g1_i2 P21097 3BHS_VACCC 1.00E-29 GO:0003854; GO:0006694; GO:0004769 3-beta-hydroxy-delta5-steroid dehydrogenase activity; steroid biosynthetic process; steroid delta-isomerase activity IPR002225; IPR016040; Lipid metabolism; steroid biosynthesis. 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase (3-beta-HSD) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)] A44L Vaccinia virus (strain Copenhagen) (VACV) TR29308_c0_g1_i4 Q62878 3BHS4_RAT 6.00E-43 GO:0003854; GO:0006700; GO:0033327; GO:0006702; GO:0005789; GO:0021766; GO:0016021; GO:0031966; GO:0034757; GO:0046686; GO:0051412; GO:0034698; GO:0010288; GO:0004769; GO:0030283 3-beta-hydroxy-delta5-steroid dehydrogenase activity; C21-steroid hormone biosynthetic process; Leydig cell differentiation; androgen biosynthetic process; endoplasmic reticulum membrane; hippocampus development; integral to membrane; mitochondrial membrane; negative regulation of iron ion transport; response to cadmium ion; response to corticosterone stimulus; response to gonadotropin stimulus; response to lead ion; steroid delta-isomerase activity; testosterone dehydrogenase [NAD(P)] activity IPR002225; IPR016040; Lipid metabolism; steroid biosynthesis. 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type IV) (3-beta-HSD IV) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)] Hsd3b6 Rattus norvegicus (Rat) TR29310_c1_g1_i1 Q1HG43 DOXA1_HUMAN 7.00E-28 GO:0005789; GO:0016021; GO:0005886; GO:0045666; GO:2000379; GO:0015031 endoplasmic reticulum membrane; integral to membrane; plasma membrane; positive regulation of neuron differentiation; positive regulation of reactive oxygen species metabolic process; protein transport IPR018469; Dual oxidase maturation factor 1 (Dual oxidase activator 1) (Numb-interacting protein) DUOXA1 NIP NUMBIP Homo sapiens (Human) TR29310_c1_g1_i2 Q1HG43 DOXA1_HUMAN 8.00E-28 GO:0005789; GO:0016021; GO:0005886; GO:0045666; GO:2000379; GO:0015031 endoplasmic reticulum membrane; integral to membrane; plasma membrane; positive regulation of neuron differentiation; positive regulation of reactive oxygen species metabolic process; protein transport IPR018469; Dual oxidase maturation factor 1 (Dual oxidase activator 1) (Numb-interacting protein) DUOXA1 NIP NUMBIP Homo sapiens (Human) TR29314_c0_g1_i1 Q5R806 PTGR2_PONAB 7.00E-114 GO:0036132; GO:0047522; GO:0005737; GO:0006693 13-prostaglandin reductase activity; 15-oxoprostaglandin 13-oxidase activity; cytoplasm; prostaglandin metabolic process IPR013149; IPR002085; IPR011032; IPR016040; Prostaglandin reductase 2 (PRG-2) (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase) PTGR2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR29315_c1_g1_i1 P10790 FABPH_BOVIN 2.00E-27 GO:0008289; GO:0005759; GO:0005215 lipid binding; mitochondrial matrix; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; "Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP) (Mammary-derived growth inhibitor) (MDGI)" FABP3 Bos taurus (Bovine) TR29316_c0_g1_i1 Q575S8 CYGB2_DANRE 2.00E-16 GO:0005737; GO:0020037; GO:0005506; GO:0019825; GO:0005344 cytoplasm; heme binding; iron ion binding; oxygen binding; oxygen transporter activity IPR000971; IPR009050; IPR012292; IPR013314; Cytoglobin-2 cygb2 cygb-2 Danio rerio (Zebrafish) (Brachydanio rerio) TR29316_c0_g1_i2 Q8UUR3 CYGB1_DANRE 1.00E-10 GO:0005737; GO:0020037; GO:0005506; GO:0019825; GO:0005344; GO:0046686 cytoplasm; heme binding; iron ion binding; oxygen binding; oxygen transporter activity; response to cadmium ion IPR000971; IPR009050; IPR012292; IPR013314; Cytoglobin-1 cygb1 cygb cygb-1 zgc:109806 Danio rerio (Zebrafish) (Brachydanio rerio) TR29320_c1_g1_i2 P51156 RAB26_RAT 1.00E-14 GO:0019002; GO:0005525; GO:0003924; GO:0000139; GO:0043001; GO:0035272; GO:0031226; GO:0045055; GO:0017157; GO:0030667; GO:0007264; GO:0030658 GMP binding; GTP binding; GTPase activity; Golgi membrane; Golgi to plasma membrane protein transport; exocrine system development; intrinsic to plasma membrane; regulated secretory pathway; regulation of exocytosis; secretory granule membrane; small GTPase mediated signal transduction; transport vesicle membrane IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-26 Rab26 Rattus norvegicus (Rat) TR29328_c0_g1_i2 Q9CZJ2 HS12B_MOUSE 2.00E-95 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR29329_c0_g1_i1 Q9QXU2 SURF1_RAT 4.00E-26 GO:0016021; GO:0005743 integral to membrane; mitochondrial inner membrane IPR002994; Surfeit locus protein 1 Surf1 Surf-1 Rattus norvegicus (Rat) TR29333_c1_g1_i1 Q05876 FYN_CHICK 6.00E-06 GO:0005524; GO:0030900; GO:0046872; GO:0001764; GO:0004715; GO:0004713; GO:0008360; GO:0015631 ATP binding; forebrain development; metal ion binding; neuron migration; non-membrane spanning protein tyrosine kinase activity; protein tyrosine kinase activity; regulation of cell shape; tubulin binding IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene c-Fyn) (p59-Fyn) FYN Gallus gallus (Chicken) TR29333_c3_g2_i3 Q9ESJ4 SPN90_MOUSE 5.00E-86 GO:0008180 COP9 signalosome IPR018556; IPR001452; NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (VIP54) (90 kDa N-WASP-interacting protein) (90 kDa SH3 protein interacting with Nck) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-binding protein) (N-WASP-binding protein) Nckipsd Spin90 Wasbp Mus musculus (Mouse) TR29335_c2_g1_i3 O60315 ZEB2_HUMAN 8.00E-09 GO:0046332; GO:0021846; GO:0005737; GO:0021766; GO:0046872; GO:0007399; GO:0001755; GO:0001843; GO:0005730; GO:0019208; GO:0043507; GO:0030177; GO:0043565; GO:0003700; GO:0001756; GO:0006351 "SMAD binding; cell proliferation in forebrain; cytoplasm; hippocampus development; metal ion binding; nervous system development; neural crest cell migration; neural tube closure; nucleolus; phosphatase regulator activity; positive regulation of JUN kinase activity; positive regulation of Wnt receptor signaling pathway; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; somitogenesis; transcription, DNA-dependent" IPR008598; IPR001356; IPR009057; IPR007087; IPR015880; IPR013087; Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) ZEB2 KIAA0569 SIP1 ZFHX1B ZFX1B HRIHFB2411 Homo sapiens (Human) TR29336_c0_g2_i1 Q5PRC7 SOSB2_DANRE 2.00E-47 GO:0070876; GO:0000724; GO:0007093; GO:0010212; GO:0003697 SOSS complex; double-strand break repair via homologous recombination; mitotic cell cycle checkpoint; response to ionizing radiation; single-stranded DNA binding IPR012340; IPR004365; SOSS complex subunit B2 (Nucleic acid-binding protein 1) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2A) (Sensor of single-strand DNA complex subunit B2) (Sensor of ssDNA subunit B2) (SOSS-B2) (Single-stranded DNA-binding protein 2) nabp1 obfc2a ssb2 zgc:101644 Danio rerio (Zebrafish) (Brachydanio rerio) TR29339_c0_g1_i2 Q68FS3 FBX7_RAT 3.00E-48 GO:0005737; GO:0005634; GO:0043234; GO:0016567; GO:0031647 cytoplasm; nucleus; protein complex; protein ubiquitination; regulation of protein stability IPR001810; IPR021625; Protein modification; protein ubiquitination. F-box only protein 7 Fbxo7 Rattus norvegicus (Rat) TR29341_c0_g1_i1 Q503V0 CHMP6_DANRE 2.00E-44 GO:0012505; GO:0031902; GO:0015031 endomembrane system; late endosome membrane; protein transport IPR005024; Charged multivesicular body protein 6 (Chromatin-modifying protein 6) chmp6 chmp6l Danio rerio (Zebrafish) (Brachydanio rerio) TR29344_c0_g1_i1 Q5RBZ2 MEP50_PONAB 3.00E-73 GO:0005737; GO:0005634 cytoplasm; nucleus IPR015943; IPR001680; IPR019775; IPR017986; Methylosome protein 50 (MEP-50) (WD repeat-containing protein 77) WDR77 MEP50 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR29345_c1_g4_i1 Q80VI1 TRI56_MOUSE 2.00E-06 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) TR29347_c0_g1_i1 Q8N0N3 BGBP_PENMO 4.00E-116 GO:0001872; GO:0005975; GO:0005576; GO:0004553; GO:0045087 "(1->3)-beta-D-glucan binding; carbohydrate metabolic process; extracellular region; hydrolase activity, hydrolyzing O-glycosyl compounds; innate immune response" IPR008985; IPR013320; IPR000757; "Beta-1,3-glucan-binding protein (GBP)" Penaeus monodon (Giant tiger prawn) TR29347_c0_g1_i3 P23903 E13B_BACCI 2.00E-30 GO:0005975; GO:0005576; GO:0042973 "carbohydrate metabolic process; extracellular region; glucan endo-1,3-beta-D-glucosidase activity" IPR008985; IPR013320; IPR000757; IPR008263; "Glucan endo-1,3-beta-glucosidase A1 (EC 3.2.1.39) ((1->3)-beta-glucan endohydrolase) ((1->3)-beta-glucanase A1)" glcA Bacillus circulans TR29347_c0_g1_i4 Q8N0N3 BGBP_PENMO 4.00E-116 GO:0001872; GO:0005975; GO:0005576; GO:0004553; GO:0045087 "(1->3)-beta-D-glucan binding; carbohydrate metabolic process; extracellular region; hydrolase activity, hydrolyzing O-glycosyl compounds; innate immune response" IPR008985; IPR013320; IPR000757; "Beta-1,3-glucan-binding protein (GBP)" Penaeus monodon (Giant tiger prawn) TR29348_c0_g1_i3 O94690 RTC6_SCHPO 7.00E-07 GO:0005762; GO:0032543; GO:0003735 mitochondrial large ribosomal subunit; mitochondrial translation; structural constituent of ribosome IPR000473; "54S ribosomal protein c83.06c, mitochondrial" SPBC83.06c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR29349_c0_g1_i1 Q7Z6M2 FBX33_HUMAN 2.00E-36 GO:0016567 P67809 protein ubiquitination IPR001810; Protein modification; protein ubiquitination. F-box only protein 33 FBXO33 FBX33 Homo sapiens (Human) TR29350_c1_g1_i2 Q80TR4 SLIT1_MOUSE 4.00E-19 GO:0048846; GO:0005509; GO:0005737; GO:0033563; GO:0040023; GO:0005615; GO:0008045; GO:0050919; GO:0051964; GO:0005102; GO:0031290; GO:0022028 axon extension involved in axon guidance; calcium ion binding; cytoplasm; dorsal/ventral axon guidance; establishment of nucleus localization; extracellular space; motor neuron axon guidance; negative chemotaxis; negative regulation of synapse assembly; receptor binding; retinal ganglion cell axon guidance; tangential migration from the subventricular zone to the olfactory bulb IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 1 protein (Slit-1) Slit1 Kiaa0813 Mus musculus (Mouse) TR29350_c3_g1_i1 P02750 A2GL_HUMAN 5.00E-22 GO:0050873; GO:0005615; GO:0016020 brown fat cell differentiation; extracellular space; membrane IPR000483; IPR001611; IPR003591; Leucine-rich alpha-2-glycoprotein (LRG) LRG1 LRG Homo sapiens (Human) TR29350_c3_g1_i2 Q7Z2Q7 LRR70_HUMAN 4.00E-20 GO:0016021 integral to membrane IPR000483; IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing protein 70 (Synleurin) LRRC70 UNQ1891/PRO4337 Homo sapiens (Human) TR29350_c4_g1_i1 Q86YT5 S13A5_HUMAN 2.00E-126 GO:0016323; GO:0015137; GO:0016021; GO:0005886; GO:0017153; GO:0015141; GO:0055085 basolateral plasma membrane; citrate transmembrane transporter activity; integral to membrane; plasma membrane; sodium:dicarboxylate symporter activity; succinate transmembrane transporter activity; transmembrane transport IPR001898; Solute carrier family 13 member 5 (Na(+)/citrate cotransporter) (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) SLC13A5 NACT Homo sapiens (Human) TR29351_c0_g1_i1 Q14678 KANK1_HUMAN 4.00E-10 GO:0008013; GO:0005737; GO:0035024; GO:0030837; GO:0030336; GO:0046627; GO:2000393; GO:0010977; GO:1900028; GO:1900025; GO:0005634; GO:0030177; GO:0035413; GO:0090303; GO:2000114; GO:0006355; GO:0032587; GO:0006351 Q9UQB8; Q9UQB8-4; P35222; Q7Z4S6; P62258; P61981; Q04917; P27348 "beta-catenin binding; cytoplasm; negative regulation of Rho protein signal transduction; negative regulation of actin filament polymerization; negative regulation of cell migration; negative regulation of insulin receptor signaling pathway; negative regulation of lamellipodium morphogenesis; negative regulation of neuron projection development; negative regulation of ruffle assembly; negative regulation of substrate adhesion-dependent cell spreading; nucleus; positive regulation of Wnt receptor signaling pathway; positive regulation of catenin import into nucleus; positive regulation of wound healing; regulation of establishment of cell polarity; regulation of transcription, DNA-dependent; ruffle membrane; transcription, DNA-dependent" IPR002110; IPR020683; IPR021939; KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) KANK1 ANKRD15 KANK KIAA0172 Homo sapiens (Human) TR29351_c1_g1_i1 Q9D2X0 ANR39_MOUSE 9.00E-10 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 39 Ankrd39 Mus musculus (Mouse) TR29351_c3_g1_i1 Q86U10 LPP60_HUMAN 2.00E-06 GO:0003847; GO:0004067; GO:0006528; GO:0016042; GO:0004622; GO:0006644 1-alkyl-2-acetylglycerophosphocholine esterase activity; asparaginase activity; asparagine metabolic process; lipid catabolic process; lysophospholipase activity; phospholipid metabolic process IPR002110; IPR020683; IPR006033; IPR006034; IPR027475; IPR027473; IPR027474; 60 kDa lysophospholipase (EC 3.1.1.5) [Includes: L-asparaginase (EC 3.5.1.1) (L-asparagine amidohydrolase); Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47)] ASPG C14orf76 Homo sapiens (Human) TR29351_c3_g2_i1 Q02357 ANK1_MOUSE 7.00E-26 GO:0030863; GO:0048821; GO:0016020; GO:0015672; GO:0006779; GO:0016529; GO:0007165; GO:0014731 cortical cytoskeleton; erythrocyte development; membrane; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; sarcoplasmic reticulum; signal transduction; spectrin-associated cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) TR29351_c7_g1_i1 Q9EP71 RAI14_MOUSE 7.00E-07 GO:0005938; GO:0005856; GO:0005739; GO:0005634 cell cortex; cytoskeleton; mitochondrion; nucleus IPR002110; IPR020683; Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) (p125) Rai14 Kiaa1334 Norpeg Mus musculus (Mouse) TR29351_c7_g1_i2 P53355 DAPK1_HUMAN 1.00E-12 GO:0005524; GO:0015629; GO:0097190; GO:0005516; GO:0004683; GO:0071346; GO:0005737; GO:0007243; GO:0043066; GO:0017148; GO:0043065; GO:0046777; GO:2000310; GO:0010506 Itself; Q14457; Q9Y2M5; Q38SD2; Q5S007; P27361; O75340; P14618; P14618-1 ATP binding; actin cytoskeleton; apoptotic signaling pathway; calmodulin binding; calmodulin-dependent protein kinase activity; cellular response to interferon-gamma; cytoplasm; intracellular protein kinase cascade; negative regulation of apoptotic process; negative regulation of translation; positive regulation of apoptotic process; protein autophosphorylation; regulation of N-methyl-D-aspartate selective glutamate receptor activity; regulation of autophagy IPR002110; IPR020683; IPR011029; IPR000488; IPR011009; IPR020675; IPR027417; IPR000719; IPR017441; IPR002290; IPR008271; Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) DAPK1 DAPK Homo sapiens (Human) TR29353_c3_g3_i1 P18503 CAS4_EPHMU 1.00E-08 GO:0005581 collagen IPR008160; Short-chain collagen C4 (Fragment) Ephydatia muelleri (Mueller's freshwater sponge) TR29357_c1_g1_i2 Q52KW0 SHAN2_XENLA 4.00E-07 GO:0030054; GO:0005737; GO:0014069; GO:0045211 cell junction; cytoplasm; postsynaptic density; postsynaptic membrane IPR001478; IPR001660; IPR013761; IPR021129; SH3 and multiple ankyrin repeat domains protein 2 (Shank2) shank2 Xenopus laevis (African clawed frog) TR29357_c1_g1_i3 Q8TDF6 GRP4_HUMAN 1.00E-09 GO:0030742; GO:0005088; GO:0007202; GO:0005509; GO:0016049; GO:0008283; GO:0005737; GO:0019992; GO:0030099; GO:0005634; GO:0005886; GO:0046579; GO:0008277; GO:0009991; GO:0007264; GO:0007169 GTP-dependent protein binding; Ras guanyl-nucleotide exchange factor activity; activation of phospholipase C activity; calcium ion binding; cell growth; cell proliferation; cytoplasm; diacylglycerol binding; myeloid cell differentiation; nucleus; plasma membrane; positive regulation of Ras protein signal transduction; regulation of G-protein coupled receptor protein signaling pathway; response to extracellular stimulus; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway IPR020454; IPR002048; IPR002219; IPR000651; IPR008937; IPR023578; IPR001895; RAS guanyl-releasing protein 4 RASGRP4 Homo sapiens (Human) TR29359_c0_g2_i1 P10791 SODC_DROVI 2.00E-66 GO:0005737; GO:0046872; GO:0004784; GO:0006801 cytoplasm; metal ion binding; superoxide dismutase activity; superoxide metabolic process IPR024134; IPR018152; IPR001424; Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) Sod GJ11304 Drosophila virilis (Fruit fly) TR29362_c0_g1_i1 Q99260 YPT6_YEAST 4.00E-19 GO:0005525; GO:0003924; GO:0005794; GO:0006886; GO:0005886; GO:0042147; GO:0007264 P39958; P53633; P53093 "GTP binding; GTPase activity; Golgi apparatus; intracellular protein transport; plasma membrane; retrograde transport, endosome to Golgi; small GTPase mediated signal transduction" IPR027417; IPR005225; IPR001806; IPR003579; GTP-binding protein YPT6 YPT6 YLR262C L8479.11 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR29362_c0_g1_i2 Q91Z61 DIRA1_MOUSE 2.00E-07 GO:0005525; GO:0003924; GO:0005886; GO:0007264 GTP binding; GTPase activity; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; GTP-binding protein Di-Ras1 (Distinct subgroup of the Ras family member 1) (Small GTP-binding tumor suppressor 1) Diras1 Gbts1 Mus musculus (Mouse) TR29362_c0_g1_i3 Q9SJ11 RABG2_ARATH 5.00E-07 GO:0005525; GO:0003924; GO:0005886; GO:0015031; GO:0007264 GTP binding; GTPase activity; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; IPR020849; Ras-related protein RABG2 (AtRABG2) (Ras-related protein Rab77) (AtRab77) (Ras-related protein Rab7a) (AtRab7a) RABG2 RAB77 RAB7A At2g21880 F7D8.20 Arabidopsis thaliana (Mouse-ear cress) TR29364_c0_g1_i1 Q62059 CSPG2_MOUSE 5.00E-15 GO:0005509; GO:0030246; GO:0007155; GO:0007507; GO:0005540; GO:0005578; GO:0001657 calcium ion binding; carbohydrate binding; cell adhesion; heart development; hyaluronic acid binding; proteinaceous extracellular matrix; ureteric bud development IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Large fibroblast proteoglycan) (PG-M) Vcan Cspg2 Mus musculus (Mouse) TR29365_c0_g1_i2 Q2M2T6 ASTER_BOVIN 4.00E-56 GO:0016021 integral to membrane IPR005351; Protein Asterix (Protein WDR83OS homolog) WDR83OS Bos taurus (Bovine) TR29368_c3_g2_i2 Q05158 CSRP2_COTJA 2.00E-37 GO:0030154; GO:0007275; GO:0005634; GO:0008270 cell differentiation; multicellular organismal development; nucleus; zinc ion binding IPR001781; Cysteine and glycine-rich protein 2 (Cysteine-rich protein 2) (CRP2) CSRP2 Coturnix coturnix japonica (Japanese quail) (Coturnix japonica) TR29369_c3_g1_i1 Q8C9J3 SPEF2_MOUSE 9.00E-57 GO:0005524; GO:0005794; GO:0035082; GO:0048854; GO:0060271; GO:0048702; GO:0009566; GO:0002520; GO:0002177; GO:0010259; GO:0019205; GO:0006139; GO:0060541; GO:0097225; GO:0007283 ATP binding; Golgi apparatus; axoneme assembly; brain morphogenesis; cilium morphogenesis; embryonic neurocranium morphogenesis; fertilization; immune system development; manchette; multicellular organismal aging; nucleobase-containing compound kinase activity; nucleobase-containing compound metabolic process; respiratory system development; sperm midpiece; spermatogenesis IPR000850; IPR010441; IPR027417; Sperm flagellar protein 2 (Protein KPL2) Spef2 Kpl2 Mus musculus (Mouse) TR29369_c3_g1_i2 Q8C9J3 SPEF2_MOUSE 7.00E-61 GO:0005524; GO:0005794; GO:0035082; GO:0048854; GO:0060271; GO:0048702; GO:0009566; GO:0002520; GO:0002177; GO:0010259; GO:0019205; GO:0006139; GO:0060541; GO:0097225; GO:0007283 ATP binding; Golgi apparatus; axoneme assembly; brain morphogenesis; cilium morphogenesis; embryonic neurocranium morphogenesis; fertilization; immune system development; manchette; multicellular organismal aging; nucleobase-containing compound kinase activity; nucleobase-containing compound metabolic process; respiratory system development; sperm midpiece; spermatogenesis IPR000850; IPR010441; IPR027417; Sperm flagellar protein 2 (Protein KPL2) Spef2 Kpl2 Mus musculus (Mouse) TR29370_c1_g1_i1 P35442 TSP2_HUMAN 2.00E-15 GO:0005604; GO:0005509; GO:0007155; GO:0005576; GO:0008201; GO:0016525 P54290 basement membrane; calcium ion binding; cell adhesion; extracellular region; heparin binding; negative regulation of angiogenesis IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR024731; IPR001791; IPR000884; IPR015455; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-2 THBS2 TSP2 Homo sapiens (Human) TR29371_c0_g1_i1 C3YWU0 FUCO_BRAFL 3.00E-66 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR29371_c0_g4_i1 Q2KIM0 FUCO_BOVIN 1.00E-07 GO:0004560; GO:0042806; GO:0006004; GO:0005764 alpha-L-fucosidase activity; fucose binding; fucose metabolic process; lysosome IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) FUCA1 Bos taurus (Bovine) TR29372_c0_g1_i1 Q6AY94 TIDC1_RAT 3.00E-17 GO:0016021; GO:0005739 integral to membrane; mitochondrion IPR003397; Translocase of inner mitochondrial membrane domain-containing protein 1 Timmdc1 Rattus norvegicus (Rat) TR29373_c1_g2_i3 Q8JHV9 BIR7A_XENLA 2.00E-47 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR29373_c1_g2_i4 Q6R7C4 IAP4_OSHVF 3.00E-09 GO:0008270 zinc ion binding IPR001370; IPR001841; IPR013083; Putative apoptosis inhibitor ORF106 ORF106 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) TR29374_c0_g3_i2 E6ZIJ1 HOIL1_DICLA 7.00E-147 GO:0071797; GO:0016874; GO:0043123; GO:0097039; GO:0043130; GO:0008270 LUBAC complex; ligase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein linear polyubiquitination; ubiquitin binding; zinc ion binding IPR001876; IPR001841; IPR017907; RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 6.3.2.-) (Heme-oxidized IRP2 ubiquitin ligase 1 homolog) (HOIL-1) rbck1 DLA_XVIII01330 Dicentrarchus labrax (European seabass) (Morone labrax) TR29374_c0_g3_i5 E6ZIJ1 HOIL1_DICLA 1.00E-133 GO:0071797; GO:0016874; GO:0043123; GO:0097039; GO:0043130; GO:0008270 LUBAC complex; ligase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein linear polyubiquitination; ubiquitin binding; zinc ion binding IPR001876; IPR001841; IPR017907; RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 6.3.2.-) (Heme-oxidized IRP2 ubiquitin ligase 1 homolog) (HOIL-1) rbck1 DLA_XVIII01330 Dicentrarchus labrax (European seabass) (Morone labrax) TR29375_c0_g1_i1 Q5RC24 QCR7_PONAB 8.00E-24 GO:0006122; GO:0005750 "mitochondrial electron transport, ubiquinol to cytochrome c; mitochondrial respiratory chain complex III" IPR003197; Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) UQCRB Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR29375_c0_g1_i2 Q9GP40 QCR7_ECHMU 2.00E-11 GO:0006122; GO:0005750 "mitochondrial electron transport, ubiquinol to cytochrome c; mitochondrial respiratory chain complex III" IPR003197; Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) UBCRBP UCRP Echinococcus multilocularis TR29377_c0_g1_i1 Q6DMN8 SPAT4_PANTR 2.00E-37 GO:0005737 cytoplasm IPR010441; Spermatogenesis-associated protein 4 SPATA4 Pan troglodytes (Chimpanzee) TR29378_c1_g1_i2 Q3UIR3 DTX3L_MOUSE 2.00E-53 GO:0005737; GO:0006302; GO:0042393; GO:0010390; GO:0005634; GO:0004842; GO:0008270 cytoplasm; double-strand break repair; histone binding; histone monoubiquitination; nucleus; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (Protein deltex-3-like) Dtx3l Bbap Mus musculus (Mouse) TR29381_c1_g1_i1 Q8N9B4 ANR42_HUMAN 1.00E-10 GO:0005634; GO:0051092; GO:1900017 nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of cytokine production involved in inflammatory response IPR002110; IPR020683; IPR018247; Ankyrin repeat domain-containing protein 42 ANKRD42 Homo sapiens (Human) TR29390_c1_g2_i1 Q502K3 ANR52_DANRE 9.00E-20 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) TR29390_c1_g2_i2 P16157 ANK1_HUMAN 3.00E-23 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR29391_c1_g1_i1 Q9P2E2 KIF17_HUMAN 7.00E-97 GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0007018; GO:0031503; GO:0015031; GO:0016192 ATP binding; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement; protein complex localization; protein transport; vesicle-mediated transport IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF17 (KIF3-related motor protein) KIF17 KIAA1405 KIF3X Homo sapiens (Human) TR29392_c0_g1_i2 Q99KE3 DOK4_MOUSE 1.00E-21 GO:0000165; GO:0007399; GO:0005543; GO:0005057; GO:0007169 MAPK cascade; nervous system development; phospholipid binding; receptor signaling protein activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR002404; IPR011993; IPR001849; Docking protein 4 (Downstream of tyrosine kinase 4) Dok4 Mus musculus (Mouse) TR29394_c0_g1_i1 Q8IW36 ZN695_HUMAN 2.00E-36 GO:0046872; GO:0003676; GO:0005634; GO:0006355 "metal ion binding; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 695 (Zinc finger protein SBZF3) ZNF695 Homo sapiens (Human) TR29394_c0_g1_i2 P26632 EGR1_DANRE 1.00E-15 GO:0003677; GO:0043010; GO:0071320; GO:0071371; GO:0005737; GO:0046872; GO:0043066; GO:0005634; GO:0048169; GO:0003700; GO:0035914; GO:0006351 "DNA binding; camera-type eye development; cellular response to cAMP; cellular response to gonadotropin stimulus; cytoplasm; metal ion binding; negative regulation of apoptotic process; nucleus; regulation of long-term neuronal synaptic plasticity; sequence-specific DNA binding transcription factor activity; skeletal muscle cell differentiation; transcription, DNA-dependent" IPR021839; IPR021849; IPR007087; IPR015880; IPR013087; Early growth response protein 1 (EGR-1) (Zinc finger protein Krox-24) egr1 krox24 Danio rerio (Zebrafish) (Brachydanio rerio) TR29394_c0_g1_i3 Q8CJ78 ZN628_MOUSE 6.00E-35 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 628 (Zinc finger protein expressed in embryonal cells and certain adult organs) Znf628 Zec Zfp628 Mus musculus (Mouse) TR29394_c0_g1_i4 Q01792 KRUP_SCICO 5.00E-17 GO:0003677; GO:0046872; GO:0005634; GO:0035282 DNA binding; metal ion binding; nucleus; segmentation IPR007087; IPR015880; IPR013087; Protein krueppel (Fragment) Kr Sciara coprophila (Fungus gnat) TR29402_c3_g1_i1 Q8IYB1 M21D2_HUMAN 8.00E-07 IPR024810; IPR024803; Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) TR29402_c3_g1_i2 Q8CEZ4 CB054_MOUSE 5.00E-07 IPR024809; IPR024810; Uncharacterized protein C2orf54 homolog Mus musculus (Mouse) TR29402_c3_g1_i3 A8E4S7 MB213_DANRE 1.00E-31 IPR024810; Protein mab-21-like 3 mab21L3 si:ch211-246m4.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR29406_c1_g1_i1 B4K4M0 HH_DROMO 6.00E-08 GO:0009653; GO:0045168; GO:0005737; GO:0005615; GO:0016539; GO:0016015; GO:0005634; GO:0008233; GO:0005886; GO:0006508; GO:0007367 anatomical structure morphogenesis; cell-cell signaling involved in cell fate commitment; cytoplasm; extracellular space; intein-mediated protein splicing; morphogen activity; nucleus; peptidase activity; plasma membrane; proteolysis; segment polarity determination IPR001657; IPR009045; IPR000320; IPR001767; IPR003586; IPR003587; IPR006141; Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product] hh GI24573 Drosophila mojavensis (Fruit fly) TR29406_c2_g1_i1 Q90419 TWHH_DANRE 2.00E-06 GO:0007267; GO:0048702; GO:0048703; GO:0060956; GO:0005615; GO:0030900; GO:0042063; GO:0048663; GO:0008233; GO:0005886; GO:0006508; GO:0055002 cell-cell signaling; embryonic neurocranium morphogenesis; embryonic viscerocranium morphogenesis; endocardial cell differentiation; extracellular space; forebrain development; gliogenesis; neuron fate commitment; peptidase activity; plasma membrane; proteolysis; striated muscle cell development IPR001657; IPR009045; IPR000320; IPR001767; IPR003586; IPR003587; Tiggy-winkle hedgehog protein (TWHH) (Sonic hedgehog protein B) (SHHB) [Cleaved into: Tiggy-winkle hedgehog protein N-product; Tiggy-winkle hedgehog protein C-product] shhb twhh Danio rerio (Zebrafish) (Brachydanio rerio) TR29407_c0_g1_i1 Q66GT5 PTPM1_MOUSE 4.00E-54 GO:0032049; GO:0046855; GO:0005743; GO:0035335; GO:0008962; GO:0046488; GO:0004439; GO:0004725; GO:0008138 "cardiolipin biosynthetic process; inositol phosphate dephosphorylation; mitochondrial inner membrane; peptidyl-tyrosine dephosphorylation; phosphatidylglycerophosphatase activity; phosphatidylinositol metabolic process; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity" IPR000340; IPR024950; IPR000387; IPR016130; Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2. Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (EC 3.1.3.27) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase) (Protein-tyrosine phosphatase mitochondrial 1) (EC 3.1.3.16) (EC 3.1.3.48) Ptpmt1 Plip Mus musculus (Mouse) TR29408_c0_g2_i1 Q2KHY5 FAP24_BOVIN 8.00E-33 GO:0003677; GO:0006281; GO:0043240 DNA binding; DNA repair; Fanconi anaemia nuclear complex IPR026985; IPR010994; Fanconi anemia-associated protein of 24 kDa FAAP24 Bos taurus (Bovine) TR29410_c0_g1_i1 Q7TN88 PK1L2_MOUSE 2.00E-09 GO:0005262; GO:0005509; GO:0030246; GO:0050982; GO:0016021; GO:0016020; GO:0007218 calcium channel activity; calcium ion binding; carbohydrate binding; detection of mechanical stimulus; integral to membrane; membrane; neuropeptide signaling pathway IPR001304; IPR016186; IPR016187; IPR000203; IPR000922; IPR008976; IPR022409; IPR002859; IPR013122; IPR003915; IPR000601; IPR001024; IPR014010; Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) Pkd1l2 Mus musculus (Mouse) TR29410_c1_g1_i1 Q4GZT3 PKD2_BOVIN 3.00E-31 GO:0007259; GO:0035904; GO:0045180; GO:0009925; GO:0001658; GO:0005262; GO:0005509; GO:0048763; GO:0007050; GO:0005911; GO:0071498; GO:0071464; GO:0071470; GO:0042994; GO:0050982; GO:0003127; GO:0071910; GO:0001892; GO:0031941; GO:0001947; GO:0071458; GO:0071556; GO:0005887; GO:0030027; GO:0016020; GO:0072177; GO:0072284; GO:0072218; GO:0072214; GO:0072219; GO:0072235; GO:0072075; GO:0035502; GO:0072208; GO:0005932; GO:0072686; GO:0031512; GO:2000134; GO:0060315; GO:0021915; GO:0031513; GO:0060674; GO:0002133; GO:0071158; GO:0031659; GO:0031587; GO:0045429; GO:0045944; GO:0005267; GO:0030814; GO:0090279; GO:0042127; GO:0051209; GO:0061441; GO:0061333; GO:0021510; GO:0005245; GO:0005248 "JAK-STAT cascade; aorta development; basal cortex; basal plasma membrane; branching involved in ureteric bud morphogenesis; calcium channel activity; calcium ion binding; calcium-induced calcium release activity; cell cycle arrest; cell-cell junction; cellular response to fluid shear stress; cellular response to hydrostatic pressure; cellular response to osmotic stress; cytoplasmic sequestering of transcription factor; detection of mechanical stimulus; detection of nodal flow; determination of liver left/right asymmetry; embryonic placenta development; filamentous actin; heart looping; integral to cytosolic side of endoplasmic reticulum membrane; integral to lumenal side of endoplasmic reticulum membrane; integral to plasma membrane; lamellipodium; membrane; mesonephric duct development; metanephric S-shaped body morphogenesis; metanephric ascending thin limb development; metanephric cortex development; metanephric cortical collecting duct development; metanephric distal tubule development; metanephric mesenchyme development; metanephric part of ureteric bud development; metanephric smooth muscle tissue development; microtubule basal body; mitotic spindle; motile primary cilium; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of ryanodine-sensitive calcium-release channel activity; neural tube development; nonmotile primary cilium; placenta blood vessel development; polycystin complex; positive regulation of cell cycle arrest; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; positive regulation of nitric oxide biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; potassium channel activity; regulation of cAMP metabolic process; regulation of calcium ion import; regulation of cell proliferation; release of sequestered calcium ion into cytosol; renal artery morphogenesis; renal tubule morphogenesis; spinal cord development; voltage-gated calcium channel activity; voltage-gated sodium channel activity" IPR027359; IPR011992; IPR002048; IPR013122; IPR003915; Polycystin-2 (Polycystic kidney disease 2 protein homolog) PKD2 Bos taurus (Bovine) TR29410_c2_g1_i1 Q2EG98 PK1L3_MOUSE 6.00E-31 GO:0005262; GO:0005509; GO:0030246; GO:0071468; GO:0001581; GO:0050982; GO:0016021; GO:0016020; GO:0007218 calcium channel activity; calcium ion binding; carbohydrate binding; cellular response to acidity; detection of chemical stimulus involved in sensory perception of sour taste; detection of mechanical stimulus; integral to membrane; membrane; neuropeptide signaling pathway IPR001304; IPR016186; IPR016187; IPR000203; IPR008976; IPR013122; IPR003915; IPR001024; Polycystic kidney disease protein 1-like 3 (PC1-like 3 protein) (Polycystin-1L3) Pkd1l3 71B10 Mus musculus (Mouse) TR29411_c0_g1_i1 Q9NRM2 ZN277_HUMAN 9.00E-140 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; Zinc finger protein 277 (Nuclear receptor-interacting factor 4) ZNF277 NRIF4 ZNF277P Homo sapiens (Human) TR29412_c0_g2_i1 Q9GQF1 JIP3_DROME 4.00E-70 GO:0000139; GO:0005078; GO:0008088; GO:0019901; GO:0046328; GO:0030140; GO:0016192 Golgi membrane; MAP-kinase scaffold activity; axon cargo transport; protein kinase binding; regulation of JNK cascade; trans-Golgi network transport vesicle; vesicle-mediated transport IPR019143; IPR011044; IPR015943; JNK-interacting protein 3 (Protein sunday driver) syd CG8110 Drosophila melanogaster (Fruit fly) TR29413_c2_g1_i1 Q29RZ4 ZNF2_BOVIN 2.00E-24 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 2 ZNF2 Bos taurus (Bovine) TR29419_c0_g1_i1 Q8YWD8 MSRA2_NOSS1 2.00E-74 GO:0006464; GO:0008113 cellular protein modification process; peptide-methionine (S)-S-oxide reductase activity IPR002569; Peptide methionine sulfoxide reductase MsrA 2 (Protein-methionine-S-oxide reductase 2) (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase 2) (Peptide Met(O) reductase 2) msrA2 alr1675 Nostoc sp. (strain PCC 7120 / UTEX 2576) TR29419_c0_g3_i1 P86890 MSRAB_ENTFL 7.00E-16 GO:0033743; GO:0008113 peptide-methionine (R)-S-oxide reductase activity; peptide-methionine (S)-S-oxide reductase activity IPR002569; IPR002579; IPR011057; Peptide methionine sulfoxide reductase msrA/msrB [Includes: Peptide methionine sulfoxide reductase msrA (Protein-methionine-S-oxide reductase) (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase); Peptide methionine sulfoxide reductase msrB (EC 1.8.4.12) (Peptide-methionine (R)-S-oxide reductase)] msrAB Enterococcus faecalis (Streptococcus faecalis) TR29422_c3_g1_i1 Q8R2K4 TAF6L_MOUSE 2.00E-45 GO:0006352; GO:0005634; GO:0051090 "DNA-dependent transcription, initiation; nucleus; regulation of sequence-specific DNA binding transcription factor activity" IPR016024; IPR011442; IPR009072; IPR004823; TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (PCAF-associated factor 65-alpha) (PAF65-alpha) Taf6l Paf65a Mus musculus (Mouse) TR29423_c2_g1_i1 Q1PRL4 LIN41_CHICK 6.00E-09 GO:0000082; GO:0000932; GO:0008543; GO:0035198; GO:0010586; GO:0035278; GO:0001843; GO:0021915; GO:2000637; GO:0051865; GO:0060964; GO:2000177; GO:0072089; GO:0004842; GO:0008270 G1/S transition of mitotic cell cycle; cytoplasmic mRNA processing body; fibroblast growth factor receptor signaling pathway; miRNA binding; miRNA metabolic process; negative regulation of translation involved in gene silencing by miRNA; neural tube closure; neural tube development; positive regulation of gene silencing by miRNA; protein autoubiquitination; regulation of gene silencing by miRNA; regulation of neural precursor cell proliferation; stem cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Gallus gallus (Chicken) TR29424_c0_g1_i1 O43511 S26A4_HUMAN 2.00E-28 GO:0016324; GO:0031526; GO:0015108; GO:0016021; GO:0015111; GO:0006885; GO:0032880; GO:0008271; GO:0007605; GO:0015116; GO:0008272 apical plasma membrane; brush border membrane; chloride transmembrane transporter activity; integral to membrane; iodide transmembrane transporter activity; regulation of pH; regulation of protein localization; secondary active sulfate transmembrane transporter activity; sensory perception of sound; sulfate transmembrane transporter activity; sulfate transport IPR018045; IPR002645; IPR001902; IPR011547; Pendrin (Sodium-independent chloride/iodide transporter) (Solute carrier family 26 member 4) SLC26A4 PDS Homo sapiens (Human) TR29424_c3_g1_i1 Q69DJ1 S26A2_BUBBU 7.00E-09 GO:0016021; GO:0008271; GO:0008272 integral to membrane; secondary active sulfate transmembrane transporter activity; sulfate transport IPR018045; IPR002645; IPR001902; IPR011547; Sulfate transporter (Solute carrier family 26 member 2) SLC26A2 Bubalus bubalis (Domestic water buffalo) TR29425_c1_g1_i1 Q812A3 ANR23_MOUSE 9.00E-06 GO:0031674; GO:0015629; GO:0006631; GO:0005634 I band; actin cytoskeleton; fatty acid metabolic process; nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) Ankrd23 Darp Mus musculus (Mouse) TR29425_c1_g1_i3 Q9Z148 EHMT2_MOUSE 2.00E-07 GO:0010424; GO:0005694; GO:0009566; GO:0046976; GO:0046974; GO:0000122; GO:0005634; GO:0035265; GO:0018027; GO:0006275; GO:0007286; GO:0007130; GO:0008270 O70237 DNA methylation on cytosine within a CG sequence; chromosome; fertilization; histone methyltransferase activity (H3-K27 specific); histone methyltransferase activity (H3-K9 specific); negative regulation of transcription from RNA polymerase II promoter; nucleus; organ growth; peptidyl-lysine dimethylation; regulation of DNA replication; spermatid development; synaptonemal complex assembly; zinc ion binding IPR002110; IPR020683; IPR003616; IPR007728; IPR003606; IPR001214; Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Protein G9a) Ehmt2 Bat8 G9a Ng36 Mus musculus (Mouse) TR29425_c1_g1_i4 Q9H560 ANR19_HUMAN 6.00E-06 IPR002110; IPR020683; Putative ankyrin repeat domain-containing protein 19 (Ankyrin repeat domain-containing protein 19 pseudogene) ANKRD19P ANKRD19 Homo sapiens (Human) TR29427_c0_g1_i1 Q3T0C8 PDLI2_BOVIN 4.00E-06 GO:0009986; GO:0005737; GO:0005856; GO:0008270 cell surface; cytoplasm; cytoskeleton; zinc ion binding IPR001478; IPR001781; PDZ and LIM domain protein 2 PDLIM2 Bos taurus (Bovine) TR29427_c0_g1_i3 A1ZA47 ZASP_DROME 3.00E-11 GO:0030018; GO:0015629; GO:0051371; GO:0005927; GO:0030239; GO:0001952; GO:0008270 Z disc; actin cytoskeleton; muscle alpha-actinin binding; muscle tendon junction; myofibril assembly; regulation of cell-matrix adhesion; zinc ion binding IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) TR29427_c0_g1_i4 A1ZA47 ZASP_DROME 7.00E-10 GO:0030018; GO:0015629; GO:0051371; GO:0005927; GO:0030239; GO:0001952; GO:0008270 Z disc; actin cytoskeleton; muscle alpha-actinin binding; muscle tendon junction; myofibril assembly; regulation of cell-matrix adhesion; zinc ion binding IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) TR29430_c1_g2_i1 Q01414 ERG_LYTVA 2.00E-38 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR011991; Transcriptional regulator ERG homolog (Fragment) ERG Lytechinus variegatus (Green sea urchin) (Variegated urchin) TR29431_c4_g1_i2 Q9Y2I1 NISCH_HUMAN 8.00E-36 GO:0008227; GO:0016601; GO:0030036; GO:0006915; GO:0005829; GO:0005769; GO:0006006; GO:0030336; GO:0048243; GO:0035091; GO:0005886; GO:0055037; GO:0008217; GO:0032228 "G-protein coupled amine receptor activity; Rac protein signal transduction; actin cytoskeleton organization; apoptotic process; cytosol; early endosome; glucose metabolic process; negative regulation of cell migration; norepinephrine secretion; phosphatidylinositol binding; plasma membrane; recycling endosome; regulation of blood pressure; regulation of synaptic transmission, GABAergic" IPR001611; IPR001683; Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein) NISCH IRAS KIAA0975 Homo sapiens (Human) TR29432_c0_g1_i1 Q26481 RL5_STYCL 2.00E-119 GO:0008097; GO:0005840; GO:0003735; GO:0006412 5S rRNA binding; ribosome; structural constituent of ribosome; translation IPR005485; IPR025607; IPR005484; 60S ribosomal protein L5 RPL5 Styela clava (Sea squirt) TR29432_c0_g1_i2 Q95276 RL5_PIG 1.00E-45 GO:0008097; GO:0005730; GO:0005840; GO:0003735; GO:0006412 5S rRNA binding; nucleolus; ribosome; structural constituent of ribosome; translation IPR005485; IPR005484; 60S ribosomal protein L5 (Fragment) RPL5 Sus scrofa (Pig) TR29433_c1_g2_i1 Q9UNA4 POLI_HUMAN 2.00E-123 GO:0006281; GO:0006260; GO:0003887; GO:0003684; GO:0046872; GO:0005654 Q15038; Q6FI35; P0CG48; P18887 DNA repair; DNA replication; DNA-directed DNA polymerase activity; damaged DNA binding; metal ion binding; nucleoplasm IPR017961; IPR001126; IPR017963; DNA polymerase iota (EC 2.7.7.7) (Eta2) (RAD30 homolog B) POLI RAD30B Homo sapiens (Human) TR29437_c1_g1_i2 P51957 NEK4_HUMAN 2.00E-47 GO:0005524; GO:0051301; GO:0046872; GO:0007067; GO:0005634; GO:0004674 ATP binding; cell division; metal ion binding; mitosis; nucleus; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) NEK4 STK2 Homo sapiens (Human) TR29438_c1_g2_i4 Q14978 NOLC1_HUMAN 5.00E-28 GO:0005524; GO:0005525; GO:0005737; GO:0007067; GO:0005730; GO:0006364 P49407; P32121; P04591 ATP binding; GTP binding; cytoplasm; mitosis; nucleolus; rRNA processing IPR006594; IPR007718; Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) NOLC1 KIAA0035 NS5ATP13 Homo sapiens (Human) TR29441_c0_g1_i1 P18719 ZG32_XENLA 1.00E-21 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Gastrula zinc finger protein XlCGF32.1 (Fragment) Xenopus laevis (African clawed frog) TR29441_c1_g1_i1 Q02386 ZNF45_HUMAN 4.00E-68 GO:0003677; GO:0046872; GO:0007275; GO:0005654; GO:0003700; GO:0006367 DNA binding; metal ion binding; multicellular organismal development; nucleoplasm; sequence-specific DNA binding transcription factor activity; transcription initiation from RNA polymerase II promoter IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 45 (BRC1744) (Zinc finger protein 13) (Zinc finger protein KOX5) ZNF45 KOX5 ZNF13 Homo sapiens (Human) TR29442_c4_g2_i1 Q9H0J4 QRIC2_HUMAN 2.00E-52 Glutamine-rich protein 2 QRICH2 Homo sapiens (Human) TR29442_c4_g2_i2 A6NNT2 CP096_HUMAN 4.00E-18 Putative uncharacterized protein C16orf96 C16orf96 Homo sapiens (Human) TR29442_c4_g2_i3 Q9H0J4 QRIC2_HUMAN 6.00E-51 Glutamine-rich protein 2 QRICH2 Homo sapiens (Human) TR29443_c1_g2_i1 O55040 NMUR1_MOUSE 4.00E-06 GO:0005887; GO:0001607; GO:0008188 integral to plasma membrane; neuromedin U receptor activity; neuropeptide receptor activity IPR000276; IPR017452; IPR005390; IPR005391; Neuromedin-U receptor 1 (NMU-R1) (G-protein coupled receptor 66) (G-protein coupled receptor FM-3) Nmur1 Gpr66 Mus musculus (Mouse) TR29444_c1_g1_i1 Q80UG2 PLXA4_MOUSE 1.00E-10 GO:0021960; GO:0021793; GO:0021610; GO:0021615; GO:0016021; GO:0005622; GO:0005886; GO:0021784; GO:0048841; GO:0050923; GO:0017154; GO:0048485; GO:0021636; GO:0021644 O35464 anterior commissure morphogenesis; chemorepulsion of branchiomotor axon; facial nerve morphogenesis; glossopharyngeal nerve morphogenesis; integral to membrane; intracellular; plasma membrane; postganglionic parasympathetic nervous system development; regulation of axon extension involved in axon guidance; regulation of negative chemotaxis; semaphorin receptor activity; sympathetic nervous system development; trigeminal nerve morphogenesis; vagus nerve morphogenesis IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A4 Plxna4 Kiaa1550 Mus musculus (Mouse) TR29444_c1_g1_i3 Q8CJH3 PLXB1_MOUSE 2.00E-14 GO:0005887; GO:0005622; GO:0033689; GO:0048812; GO:0043931; GO:0032321; GO:0050772; GO:0014068; GO:0008360; GO:0051493; GO:0017154; GO:0002116; GO:1900220 Q68FM7; Q8R4H2 integral to plasma membrane; intracellular; negative regulation of osteoblast proliferation; neuron projection morphogenesis; ossification involved in bone maturation; positive regulation of Rho GTPase activity; positive regulation of axonogenesis; positive regulation of phosphatidylinositol 3-kinase cascade; regulation of cell shape; regulation of cytoskeleton organization; semaphorin receptor activity; semaphorin receptor complex; semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-B1 Plxnb1 Kiaa0407 Mus musculus (Mouse) TR29444_c2_g1_i1 Q9UIW2 PLXA1_HUMAN 1.00E-14 GO:0007411; GO:0005737; GO:0060666; GO:0016021; GO:0005634; GO:0005886; GO:0017154; GO:0002116 axon guidance; cytoplasm; dichotomous subdivision of terminal units involved in salivary gland branching; integral to membrane; nucleus; plasma membrane; semaphorin receptor activity; semaphorin receptor complex IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A1 (Semaphorin receptor NOV) PLXNA1 NOV PLXN1 Homo sapiens (Human) TR29444_c2_g2_i1 Q9V4A7 PLXB_DROME 5.00E-12 GO:0016021; GO:0005622; GO:0008045; GO:0035021; GO:0005886; GO:0035025; GO:0004872; GO:0007165 integral to membrane; intracellular; motor neuron axon guidance; negative regulation of Rac protein signal transduction; plasma membrane; positive regulation of Rho protein signal transduction; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-B plexB CG17245 Drosophila melanogaster (Fruit fly) TR29445_c0_g2_i1 Q53HC5 KLH26_HUMAN 7.00E-20 IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 26 KLHL26 Homo sapiens (Human) TR29445_c1_g2_i1 Q9CZ49 KLH35_MOUSE 3.00E-14 IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 35 Klhl35 Mus musculus (Mouse) TR29445_c1_g3_i1 Q70JS2 KELC_ANOST 4.00E-12 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR006652; Ring canal kelch homolog (Kelch-like protein 1) [Cleaved into: Kelch short protein] kel Anopheles stephensi (Indo-Pakistan malaria mosquito) TR29446_c1_g1_i2 A8J4S9 TREA_APIME 1.00E-157 GO:0004555; GO:0016021; GO:0005991 "alpha,alpha-trehalase activity; integral to membrane; trehalose metabolic process" IPR008928; IPR001661; IPR018232; "Trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase)" Apis mellifera (Honeybee) TR29447_c1_g2_i1 Q7RTY1 MOT9_HUMAN 7.00E-19 GO:0016021; GO:0005886; GO:0015293; GO:0046415 integral to membrane; plasma membrane; symporter activity; urate metabolic process IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 C10orf36 MCT9 Homo sapiens (Human) TR29447_c2_g1_i1 A1L1W9 MOT10_DANRE 3.00E-24 GO:0016021; GO:0005886; GO:0055085 integral to membrane; plasma membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 10 (MCT 10) (Solute carrier family 16 member 10) slc16a10 si:ch211-241j12.1 zgc:158478 Danio rerio (Zebrafish) (Brachydanio rerio) TR29450_c0_g1_i1 Q6GNV7 DIRC2_XENLA 4.00E-82 GO:0016021; GO:0005765; GO:0055085 integral to membrane; lysosomal membrane; transmembrane transport IPR011701; IPR016196; Disrupted in renal carcinoma protein 2 homolog dirc2 Xenopus laevis (African clawed frog) TR29458_c0_g2_i1 Q6PCW6 CNFN_MOUSE 3.00E-15 GO:0001533; GO:0005737; GO:0031424 cornified envelope; cytoplasm; keratinization IPR006461; Cornifelin Cnfn Mus musculus (Mouse) TR29461_c0_g1_i1 O43826 G6PT1_HUMAN 1.00E-72 GO:0005789; GO:0042593; GO:0006006; GO:0015758; GO:0015152; GO:0030176; GO:0016021; GO:0044281 endoplasmic reticulum membrane; glucose homeostasis; glucose metabolic process; glucose transport; glucose-6-phosphate transmembrane transporter activity; integral to endoplasmic reticulum membrane; integral to membrane; small molecule metabolic process IPR011701; IPR020846; IPR016196; IPR021159; IPR000849; Glucose-6-phosphate translocase (Glucose-5-phosphate transporter) (Solute carrier family 37 member 4) (Transformation-related gene 19 protein) (TRG-19) SLC37A4 G6PT G6PT1 PRO0685 TRG19 Homo sapiens (Human) TR29462_c0_g1_i1 Q9JJR5 AKIP1_MOUSE 2.00E-09 GO:0005634; GO:0034446 nucleus; substrate adhesion-dependent cell spreading A-kinase-interacting protein 1 (Breast cancer-associated gene 3 protein) (PKA-interacting protein) (Proline-rich protein BCA3) Akip1 Bca3 Mus musculus (Mouse) TR29465_c0_g1_i1 Q3ZBA3 PKHA2_BOVIN 2.00E-10 GO:0005737; GO:0005634; GO:0005543; GO:0005886 cytoplasm; nucleus; phospholipid binding; plasma membrane IPR011993; IPR001849; Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) PLEKHA2 Bos taurus (Bovine) TR29465_c2_g1_i3 Q8K0U4 HS12A_MOUSE 1.00E-49 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR29465_c2_g1_i4 Q37106 DNAK_CYAPA 2.00E-09 GO:0005524; GO:0009842; GO:0006457; GO:0006950 ATP binding; cyanelle; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein dnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK-A; dnaK-B Cyanophora paradoxa TR29468_c1_g1_i1 O55057 PDE6D_MOUSE 2.00E-81 GO:0047555; GO:0005095; GO:0031410; GO:0030659; GO:0005829; GO:0007602; GO:0033124; GO:0007601 Q92834; Q92834-2 "3',5'-cyclic-GMP phosphodiesterase activity; GTPase inhibitor activity; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; phototransduction; regulation of GTP catabolic process; visual perception" IPR008015; IPR014756; IPR017287; "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta)" Pde6d Mus musculus (Mouse) TR2947_c0_g1_i1 Q96MM6 HS12B_HUMAN 6.00E-10 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR29470_c0_g1_i1 Q0P5A2 COQ5_BOVIN 5.00E-117 GO:0008168; GO:0005739; GO:0006744 methyltransferase activity; mitochondrion; ubiquinone biosynthetic process IPR004033; IPR023576; IPR025765; Cofactor biosynthesis; ubiquinone biosynthesis. "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (EC 2.1.1.201) (Ubiquinone biosynthesis methyltransferase COQ5)" COQ5 Bos taurus (Bovine) TR29473_c0_g2_i1 Q07598 NLTP_CHICK 0 GO:0006869; GO:0005739; GO:0005777; GO:0033814; GO:0032934 lipid transport; mitochondrion; peroxisome; propanoyl-CoA C-acyltransferase activity; sterol binding IPR003033; IPR016039; IPR016038; IPR020615; IPR020617; IPR020613; IPR020616; Non-specific lipid-transfer protein (NSL-TP) (EC 2.3.1.176) (Propanoyl-CoA C-acyltransferase) (SCP-chi) (SCPX) (Sterol carrier protein 2) (SCP-2) (Sterol carrier protein X) (SCP-X) (Fragment) SCP2 Gallus gallus (Chicken) TR29477_c0_g1_i3 Q9BRT2 MNF1_HUMAN 3.00E-20 GO:0042645; GO:0005634 mitochondrial nucleoid; nucleus Ubiquinol-cytochrome-c reductase complex assembly factor 2 (Breast cancer-associated protein SGA-81M) (Mitochondrial nucleoid factor 1) (Mitochondrial protein M19) UQCC2 C6orf125 MNF1 Homo sapiens (Human) TR29484_c0_g1_i1 Q6P2X9 MOT12_XENTR 5.00E-26 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR29488_c0_g1_i1 O94762 RECQ5_HUMAN 1.00E-103 GO:0005524; GO:0008026; GO:0003678; GO:0006310; GO:0006281; GO:0006260; GO:0016591; GO:0000993; GO:0051301; GO:0051304; GO:0005737; GO:0007067; GO:0034244; GO:0031965; GO:0003676; GO:0005730 "ATP binding; ATP-dependent helicase activity; DNA helicase activity; DNA recombination; DNA repair; DNA replication; DNA-directed RNA polymerase II, holoenzyme; RNA polymerase II core binding; cell division; chromosome separation; cytoplasm; mitosis; negative regulation of transcription elongation from RNA polymerase II promoter; nuclear membrane; nucleic acid binding; nucleolus" IPR011545; IPR002464; IPR004589; IPR014001; IPR001650; IPR027417; IPR010716; IPR011991; "ATP-dependent DNA helicase Q5 (EC 3.6.4.12) (DNA helicase, RecQ-like type 5) (RecQ5) (RecQ protein-like 5)" RECQL5 RECQ5 Homo sapiens (Human) TR29489_c0_g1_i1 A6NAF9 TRD7A_DANRE 2.00E-17 GO:0005737; GO:0070306; GO:0002089; GO:0003729; GO:0010608; GO:0035770; GO:0007283 cytoplasm; lens fiber cell differentiation; lens morphogenesis in camera-type eye; mRNA binding; posttranscriptional regulation of gene expression; ribonucleoprotein granule; spermatogenesis IPR025605; IPR002999; Tudor domain-containing protein 7A tdrd7a tdrd7 zgc:56669 Danio rerio (Zebrafish) (Brachydanio rerio) TR29490_c3_g1_i1 F6UH96 SPRTN_XENTR 1.00E-31 GO:0070530; GO:0005694; GO:0046872; GO:0005634; GO:0031398; GO:0009411; GO:0019985 K63-linked polyubiquitin binding; chromosome; metal ion binding; nucleus; positive regulation of protein ubiquitination; response to UV; translesion synthesis IPR006640; SprT-like domain-containing protein Spartan (Protein with SprT-like domain at the N terminus) (Spartan) sprtn Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR29491_c1_g2_i1 Q75VX8 FA59B_HUMAN 8.00E-06 IPR025946; IPR013761; GRB2-associated and regulator of MAPK protein-like (GRB2-associated and regulator of MAPK1-like) GAREML FAM59B KIAA2038 HRIHFB2063 Homo sapiens (Human) TR29492_c1_g1_i1 A0MS83 ZN148_DANRE 8.00E-25 GO:0003677; GO:0030097; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; hemopoiesis; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) znf148 zbp89 si:dkey-101k6.6 Danio rerio (Zebrafish) (Brachydanio rerio) TR29492_c1_g2_i1 Q14590 ZN235_HUMAN 7.00E-47 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) TR29498_c3_g1_i1 Q9JI67 B3GT5_MOUSE 4.00E-12 GO:0000139; GO:0005783; GO:0008378; GO:0016021; GO:0006486 Golgi membrane; endoplasmic reticulum; galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (Stage-specific embryonic antigen 3 synthase) (SSEA-3 synthase) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5)" B3galt5 B3gt5 Mus musculus (Mouse) TR29498_c3_g1_i2 Q9Z0F0 B3GT4_MOUSE 2.00E-11 GO:0000139; GO:0047915; GO:0016021; GO:0006486 Golgi membrane; ganglioside galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 4 (Beta-1,3-GalTase 4) (Beta3Gal-T4) (Beta3GalT4) (b3Gal-T4) (EC 2.4.1.62) (Gal-T2) (Ganglioside galactosyltransferase) (UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase)" B3galt4 Mus musculus (Mouse) TR29500_c0_g1_i1 O14463 TRX1_SCHPO 1.00E-28 GO:0016209; GO:0045454; GO:0019344; GO:0005829; GO:0006662; GO:0042744; GO:0005634; GO:1900409; GO:0003756; GO:0015035; GO:0019379 "antioxidant activity; cell redox homeostasis; cysteine biosynthetic process; cytosol; glycerol ether metabolic process; hydrogen peroxide catabolic process; nucleus; positive regulation of cellular response to oxidative stress; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)" IPR005746; IPR012336; IPR017937; IPR013766; Thioredoxin-1 (TR-1) (Trx-1) trx1 trx2 SPAC7D4.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR29500_c0_g1_i2 P29429 THIO_EMENI 5.00E-22 GO:0045454; GO:0034599; GO:0015036; GO:0006662; GO:0015035 cell redox homeostasis; cellular response to oxidative stress; disulfide oxidoreductase activity; glycerol ether metabolic process; protein disulfide oxidoreductase activity IPR005746; IPR012336; IPR017937; IPR013766; Thioredoxin (Trx) TRX1 AN0170 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR29503_c2_g1_i1 Q19958 STO2_CAEEL 7.00E-28 GO:0016021 integral to membrane IPR001107; IPR018080; IPR001972; Stomatin-2 sto-2 F32A6.5 Caenorhabditis elegans TR29503_c4_g1_i2 Q6YN16 HSDL2_HUMAN 2.00E-19 GO:0005739; GO:0016491; GO:0005777; GO:0032934 mitochondrion; oxidoreductase activity; peroxisome; sterol binding IPR002198; IPR002347; IPR016040; IPR020904; IPR003033; Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-) HSDL2 C9orf99 Homo sapiens (Human) TR29507_c0_g1_i1 Q4G0P3 HYDIN_HUMAN 1.00E-39 IPR008962 Hydrocephalus-inducing protein homolog HYDIN HYDIN1 KIAA1864 Homo sapiens (Human) TR29507_c1_g2_i2 Q4G0P3 HYDIN_HUMAN 0 IPR008962 Hydrocephalus-inducing protein homolog HYDIN HYDIN1 KIAA1864 Homo sapiens (Human) TR2951_c0_g1_i1 Q9NYL2 MLTK_HUMAN 4.00E-20 GO:0005524; GO:0000077; GO:0004709; GO:0007257; GO:0007050; GO:0008219; GO:0030154; GO:0008283; GO:0005737; GO:0007010; GO:0000287; GO:0005634; GO:0043065; GO:0009314 Q16512; O75582; P63104 ATP binding; DNA damage checkpoint; MAP kinase kinase kinase activity; activation of JUN kinase activity; cell cycle arrest; cell death; cell differentiation; cell proliferation; cytoplasm; cytoskeleton organization; magnesium ion binding; nucleus; positive regulation of apoptotic process; response to radiation IPR011009; IPR000719; IPR001660; IPR013761; IPR021129; IPR001245; IPR008271; Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) MLTK ZAK HCCS4 Homo sapiens (Human) TR29511_c0_g1_i1 Q28479 IDH3B_MACFA 6.00E-151 GO:0051287; GO:0004449; GO:0000287; GO:0005739; GO:0006099 NAD binding; isocitrate dehydrogenase (NAD+) activity; magnesium ion binding; mitochondrion; tricarboxylic acid cycle IPR019818; IPR001804; IPR004434; IPR024084; "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta)" IDH3B QnpA-21101 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR29511_c0_g1_i2 Q68FX0 IDH3B_RAT 2.00E-151 GO:0006103; GO:0051287; GO:0006734; GO:0004449; GO:0006102; GO:0000287; GO:0005962; GO:0006099 2-oxoglutarate metabolic process; NAD binding; NADH metabolic process; isocitrate dehydrogenase (NAD+) activity; isocitrate metabolic process; magnesium ion binding; mitochondrial isocitrate dehydrogenase complex (NAD+); tricarboxylic acid cycle IPR019818; IPR001804; IPR004434; IPR024084; "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta)" Idh3B Rattus norvegicus (Rat) TR29512_c0_g1_i2 Q86V25 VASH2_HUMAN 1.00E-103 GO:0005737; GO:0045766; GO:0001938 cytoplasm; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation IPR028131; Vasohibin-2 (Vasohibin-like protein) VASH2 VASHL Homo sapiens (Human) TR29513_c0_g1_i1 Q17DK5 CRY1_AEDAE 1.00E-51 GO:0003913; GO:0006281; GO:0009882; GO:0005737; GO:0050660; GO:0045892; GO:0005641; GO:0048471; GO:0000060; GO:0018298; GO:0042752; GO:0048511; GO:0006351 "DNA photolyase activity; DNA repair; blue light photoreceptor activity; cytoplasm; flavin adenine dinucleotide binding; negative regulation of transcription, DNA-dependent; nuclear envelope lumen; perinuclear region of cytoplasm; protein import into nucleus, translocation; protein-chromophore linkage; regulation of circadian rhythm; rhythmic process; transcription, DNA-dependent" IPR002081; IPR018394; IPR006050; IPR005101; IPR014729; Cryptochrome-1 cry AAEL004146 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR29513_c0_g2_i1 Q4KML2 CRYD_DANRE 3.00E-12 GO:0003913; GO:0006281; GO:0018298 DNA photolyase activity; DNA repair; protein-chromophore linkage IPR002081; IPR014133; IPR006050; IPR005101; IPR014729; Cryptochrome DASH (Protein CRY-DASH) (zCRY-DASH) cry-dash Danio rerio (Zebrafish) (Brachydanio rerio) TR29513_c3_g1_i2 Q17DK5 CRY1_AEDAE 3.00E-117 GO:0003913; GO:0006281; GO:0009882; GO:0005737; GO:0050660; GO:0045892; GO:0005641; GO:0048471; GO:0000060; GO:0018298; GO:0042752; GO:0048511; GO:0006351 "DNA photolyase activity; DNA repair; blue light photoreceptor activity; cytoplasm; flavin adenine dinucleotide binding; negative regulation of transcription, DNA-dependent; nuclear envelope lumen; perinuclear region of cytoplasm; protein import into nucleus, translocation; protein-chromophore linkage; regulation of circadian rhythm; rhythmic process; transcription, DNA-dependent" IPR002081; IPR018394; IPR006050; IPR005101; IPR014729; Cryptochrome-1 cry AAEL004146 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR29516_c7_g1_i1 Q9Z2E9 BSCL2_MOUSE 4.00E-32 GO:0045444; GO:0030176; GO:0016042; GO:0034389; GO:0019915; GO:0050995 fat cell differentiation; integral to endoplasmic reticulum membrane; lipid catabolic process; lipid particle organization; lipid storage; negative regulation of lipid catabolic process IPR009617; Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog) Bscl2 Gng3lg MNCb-2630 Mus musculus (Mouse) TR29518_c0_g1_i1 P35478 CYTX_BOVIN 1.00E-09 GO:0004869; GO:0005737; GO:0010951 cysteine-type endopeptidase inhibitor activity; cytoplasm; negative regulation of endopeptidase activity IPR000010; IPR018073; IPR001713; Stefin-C Bos taurus (Bovine) TR29518_c0_g1_i3 P25417 CYTB_BOVIN 9.00E-09 GO:0004869; GO:0005737; GO:0010951 cysteine-type endopeptidase inhibitor activity; cytoplasm; negative regulation of endopeptidase activity IPR000010; IPR018073; IPR001713; Cystatin-B (Stefin-B) CSTB CST6 Bos taurus (Bovine) TR29518_c0_g1_i4 Q65YR7 CYTA2_DICDI 1.00E-07 GO:0004869; GO:0005829; GO:0006508 cysteine-type endopeptidase inhibitor activity; cytosol; proteolysis IPR000010; IPR001713; Cystatin-A2 cpiB DDB_G0280439 Dictyostelium discoideum (Slime mold) TR29519_c0_g1_i1 Q9BVG9 PTSS2_HUMAN 6.00E-87 GO:0003882; GO:0005789; GO:0016021; GO:0006659 CDP-diacylglycerol-serine O-phosphatidyltransferase activity; endoplasmic reticulum membrane; integral to membrane; phosphatidylserine biosynthetic process IPR004277; Phospholipid metabolism; phosphatidylserine biosynthesis. Phosphatidylserine synthase 2 (PSS-2) (PtdSer synthase 2) (EC 2.7.8.29) (Serine-exchange enzyme II) PTDSS2 PSS2 Homo sapiens (Human) TR29519_c1_g1_i1 Q803C9 PTSS1_DANRE 6.00E-31 GO:0005789; GO:0016021; GO:0006659; GO:0016740 endoplasmic reticulum membrane; integral to membrane; phosphatidylserine biosynthetic process; transferase activity IPR004277; Phospholipid metabolism; phosphatidylserine biosynthesis. Phosphatidylserine synthase 1 (PSS-1) (PtdSer synthase 1) (EC 2.7.8.29) (Serine-exchange enzyme I) ptdss1 si:ch211-269k10 zgc:55906 Danio rerio (Zebrafish) (Brachydanio rerio) TR29520_c0_g1_i1 O13834 PTR1_SCHPO 6.00E-20 GO:0006406; GO:0005634; GO:0004842 mRNA export from nucleus; nucleus; ubiquitin-protein ligase activity IPR025527; IPR010309; IPR010314; IPR000569; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase ptr1 (EC 6.3.2.-) (Poly(A)+ RNA transport protein 1) ptr1 SPAC19D5.04 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR29520_c3_g1_i1 Q6P560 ZN182_MOUSE 2.00E-16 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 182 (Zinc finger protein 21) Znf182 Zfp182 Znf21 Mus musculus (Mouse) TR29520_c4_g1_i2 Q7Z6Z7 HUWE1_HUMAN 2.00E-155 GO:0003677; GO:0006284; GO:0030154; GO:0005737; GO:0016574; GO:0005634; GO:0006513; GO:0000209; GO:0042787; GO:0004842 Q8N726; P04637; Q13107 DNA binding; base-excision repair; cell differentiation; cytoplasm; histone ubiquitination; nucleus; protein monoubiquitination; protein polyubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR016024; IPR025527; IPR010309; IPR010314; IPR000569; IPR009060; IPR015940; IPR000449; IPR004170; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase HUWE1 (EC 6.3.2.-) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)" HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272 Homo sapiens (Human) TR29520_c5_g1_i3 Q8H0T4 UPL2_ARATH 4.00E-17 GO:0005829; GO:0005739; GO:0005634; GO:0042787; GO:0004842 cytosol; mitochondrion; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR011989; IPR016024; IPR025527; IPR010309; IPR010314; IPR000569; IPR009060; IPR015940; IPR000449; IPR003903; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UPL2 (Ubiquitin-protein ligase 2) (EC 6.3.2.-) UPL2 At1g70320 F17O7.14/F17O7.15 Arabidopsis thaliana (Mouse-ear cress) TR29522_c8_g1_i1 P57709 AT2C1_BOVIN 0 GO:0005524; GO:0032468; GO:0032472; GO:0000139; GO:0031532; GO:0005509; GO:0016339; GO:0005388; GO:0030026; GO:0008544; GO:0016021; GO:0030145; GO:0015410; GO:0043123; GO:0004871; GO:0005802 ATP binding; Golgi calcium ion homeostasis; Golgi calcium ion transport; Golgi membrane; actin cytoskeleton reorganization; calcium ion binding; calcium-dependent cell-cell adhesion; calcium-transporting ATPase activity; cellular manganese ion homeostasis; epidermis development; integral to membrane; manganese ion binding; manganese-transporting ATPase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity; trans-Golgi network IPR006413; IPR006068; IPR004014; IPR018303; IPR023298; IPR008250; IPR001757; IPR023214; Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 3.6.3.8) (Secretory pathway Ca(2+)-transporting ATPase) ATP2C1 SPCA Bos taurus (Bovine) TR29524_c0_g1_i1 Q96BK5 PINX1_HUMAN 8.00E-61 GO:0000781; GO:0000777; GO:0000776; GO:0005739; GO:0007080; GO:0008285; GO:0000228; GO:0005730; GO:0005819; GO:0010521; GO:0007004; GO:0070034 P23526; P62158; Q14444; Q9BZE4; Q86YZ3; P11940; Q13310; Q9NW61; P62750; P62899; P46783; P62249; P39019; P62857; P61247; P10599 "chromosome, telomeric region; condensed chromosome kinetochore; kinetochore; mitochondrion; mitotic metaphase plate congression; negative regulation of cell proliferation; nuclear chromosome; nucleolus; spindle; telomerase inhibitor activity; telomere maintenance via telomerase; telomeric RNA binding" IPR000467; PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1) PINX1 LPTL LPTS Homo sapiens (Human) TR29525_c2_g1_i1 A9ULZ2 BIR7B_XENLA 5.00E-16 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) TR29526_c0_g1_i1 Q6IE26 EPHX4_MOUSE 3.00E-92 GO:0016787; GO:0016021; GO:0008152 hydrolase activity; integral to membrane; metabolic process IPR000073; IPR000639; Epoxide hydrolase 4 (EC 3.3.-.-) (Abhydrolase domain-containing protein 7) (Epoxide hydrolase-related protein) Ephx4 Abhd7 Ephxrp Mus musculus (Mouse) TR29530_c4_g3_i1 Q6A000 K0753_MOUSE 1.00E-12 Uncharacterized protein KIAA0753 Kiaa0753 Mus musculus (Mouse) TR29531_c0_g1_i1 Q8IX29 FBX16_HUMAN 6.00E-53 IPR001810; F-box only protein 16 FBXO16 FBX16 Homo sapiens (Human) TR29536_c0_g1_i1 Q9D9M5 PHOP2_MOUSE 4.00E-59 GO:0016311; GO:0046872; GO:0033883 dephosphorylation; metal ion binding; pyridoxal phosphatase activity IPR023214; IPR006383; IPR016965; IPR006384; Pyridoxal phosphate phosphatase PHOSPHO2 (EC 3.1.3.74) Phospho2 Mus musculus (Mouse) TR29538_c0_g1_i1 A2BDA5 DCA15_XENLA 1.00E-34 GO:0016567 protein ubiquitination Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 15 dcaf15 Xenopus laevis (African clawed frog) TR29541_c0_g1_i1 Q6WRX3 ZY11A_HUMAN 1.00E-27 IPR011989; IPR016024; Protein zyg-11 homolog A ZYG11A ZYG11 Homo sapiens (Human) TR29541_c1_g1_i1 Q3UFS0 ZY11B_MOUSE 1.00E-38 IPR011989; IPR016024; IPR001611; Protein zyg-11 homolog B Zyg11b Kiaa1730 Mus musculus (Mouse) TR29541_c4_g1_i1 Q9C0D3 ZY11B_HUMAN 5.00E-93 IPR011989; IPR016024; IPR001611; Protein zyg-11 homolog B ZYG11B KIAA1730 Homo sapiens (Human) TR29542_c0_g1_i2 Q9DBY5 CBX6_MOUSE 4.00E-21 GO:0031519; GO:0016568; GO:0000792; GO:0000122; GO:0003727; GO:0006351 "PcG protein complex; chromatin modification; heterochromatin; negative regulation of transcription from RNA polymerase II promoter; single-stranded RNA binding; transcription, DNA-dependent" IPR017984; IPR023780; IPR000953; IPR016197; IPR023779; Chromobox protein homolog 6 Cbx6 Mus musculus (Mouse) TR29544_c0_g1_i1 Q12908 NTCP2_HUMAN 4.00E-30 GO:0016324; GO:0008206; GO:0008508; GO:0005887; GO:0005634; GO:0000502 apical plasma membrane; bile acid metabolic process; bile acid:sodium symporter activity; integral to plasma membrane; nucleus; proteasome complex IPR004710; IPR002657; "Ileal sodium/bile acid cotransporter (Apical sodium-dependent bile acid transporter) (ASBT) (Ileal Na(+)/bile acid cotransporter) (Ileal sodium-dependent bile acid transporter) (IBAT) (ISBT) (Na(+)-dependent ileal bile acid transporter) (Sodium/taurocholate cotransporting polypeptide, ileal) (Solute carrier family 10 member 2)" SLC10A2 ASBT ISBT NTCP2 Homo sapiens (Human) TR29545_c3_g1_i1 Q91XA8 KLD8A_MOUSE 1.00E-20 IPR015916; IPR015915; IPR006652; Kelch domain-containing protein 8A Klhdc8a Mus musculus (Mouse) TR29546_c1_g1_i1 A5PJF4 TM218_BOVIN 1.00E-09 GO:0016021 integral to membrane IPR026771; Transmembrane protein 218 TMEM218 Bos taurus (Bovine) TR29546_c1_g1_i2 Q7SZ56 TM218_DANRE 1.00E-08 GO:0016021 integral to membrane IPR026771; Transmembrane protein 218 tmem218 zgc:63675 Danio rerio (Zebrafish) (Brachydanio rerio) TR29546_c2_g1_i1 Q2YDI0 RM11_BOVIN 1.00E-52 GO:0005739; GO:0005840; GO:0003735; GO:0006412 mitochondrion; ribosome; structural constituent of ribosome; translation IPR000911; IPR006519; IPR020783; IPR020784; "39S ribosomal protein L11, mitochondrial (L11mt) (MRP-L11)" MRPL11 Bos taurus (Bovine) TR29551_c1_g1_i1 Q96GY0 ZC21A_HUMAN 2.00E-47 GO:0046872 metal ion binding IPR026319; Zinc finger C2HC domain-containing protein 1A ZC2HC1A C8orf70 FAM164A CGI-62 Homo sapiens (Human) TR29552_c3_g2_i1 Q3T0Y3 ST1B1_BOVIN 1.00E-25 GO:0004062; GO:0005737; GO:0009812; GO:0008202; GO:0051923; GO:0042403; GO:0006805 aryl sulfotransferase activity; cytoplasm; flavonoid metabolic process; steroid metabolic process; sulfation; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) SULT1B1 Bos taurus (Bovine) TR29553_c0_g1_i1 Q3BAI2 YCX91_PHAAO 3.00E-11 GO:0009507 chloroplast Uncharacterized protein ORF91 Phalaenopsis aphrodite subsp. formosana (Moth orchid) TR29553_c0_g3_i1 Q3BAI2 YCX91_PHAAO 6.00E-11 GO:0009507 chloroplast Uncharacterized protein ORF91 Phalaenopsis aphrodite subsp. formosana (Moth orchid) TR29554_c2_g2_i1 Q80XP9 WNK3_MOUSE 8.00E-114 GO:0005524; GO:0005912; GO:0005737; GO:0090004; GO:0010800; GO:2000688; GO:2000682; GO:2000651; GO:0010765; GO:0046777; GO:0004672; GO:0004674; GO:0005923 ATP binding; adherens junction; cytoplasm; positive regulation of establishment of protein localization to plasma membrane; positive regulation of peptidyl-threonine phosphorylation; positive regulation of rubidium ion transmembrane transporter activity; positive regulation of rubidium ion transport; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; protein autophosphorylation; protein kinase activity; protein serine/threonine kinase activity; tight junction IPR011009; IPR024678; IPR000719; IPR002290; IPR008271; Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) Wnk3 Mus musculus (Mouse) TR29554_c2_g3_i2 Q6XUX1 DUSTY_MOUSE 1.00E-46 GO:0005524; GO:0005737; GO:0045111; GO:0005634; GO:0018108; GO:0004674; GO:0004712; GO:0004713 ATP binding; cytoplasm; intermediate filament cytoskeleton; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (Receptor-interacting serine/threonine-protein kinase 5) Dstyk Ripk5 Mus musculus (Mouse) TR29555_c0_g1_i1 Q8BZ25 ANKK1_MOUSE 6.00E-14 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR001245; IPR008271; Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) Ankk1 Mus musculus (Mouse) TR29555_c1_g1_i1 Q9Z2X2 PSD10_MOUSE 1.00E-05 GO:0015629; GO:0006915; GO:0005737; GO:0007253; GO:0045111; GO:0043518; GO:0043409; GO:0032088; GO:0043066; GO:0090201; GO:0000122; GO:0005634; GO:0030307; GO:0045737; GO:0032436; GO:0031398; GO:0070682; GO:0008540 "actin cytoskeleton; apoptotic process; cytoplasm; cytoplasmic sequestering of NF-kappaB; intermediate filament cytoskeleton; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of MAPK cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of apoptotic process; negative regulation of release of cytochrome c from mitochondria; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of cell growth; positive regulation of cyclin-dependent protein kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; proteasome regulatory particle assembly; proteasome regulatory particle, base subcomplex" IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) Psmd10 Mus musculus (Mouse) TR29556_c0_g1_i2 P29691 EF2_CAEEL 0 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; translation elongation factor activity IPR000795; IPR009022; IPR000640; IPR027417; IPR020568; IPR014721; IPR005225; IPR009000; IPR005517; IPR004161; Elongation factor 2 (EF-2) eef-2 F25H5.4 Caenorhabditis elegans TR29556_c0_g2_i1 Q8SQT7 EF2_ENCCU 3.00E-108 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0019843; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; rRNA binding; translation elongation factor activity IPR000795; IPR009022; IPR000640; IPR027417; IPR020568; IPR014721; IPR005225; IPR009000; IPR005517; IPR004161; Protein biosynthesis; polypeptide chain elongation. Elongation factor 2 (EF-2) (Eukaryotic elongation factor 2) (eEF2) (Ribosomal translocase) (Translation elongation factor 2) EFT1 ECU11_1460 Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) TR29558_c0_g2_i1 P11528 GCY_ARBPU 5.00E-45 GO:0005524; GO:0005525; GO:0004383; GO:0016021; GO:0004672 ATP binding; GTP binding; guanylate cyclase activity; integral to membrane; protein kinase activity IPR001828; IPR011009; IPR028082; IPR000719; IPR001245; Resact receptor (EC 4.6.1.2) (Guanylate cyclase) Arbacia punctulata (Punctuate sea urchin) TR29558_c3_g1_i1 P16065 GCY_STRPU 2.00E-106 GO:0005524; GO:0005525; GO:0004383; GO:0016021; GO:0035556; GO:0004672 ATP binding; GTP binding; guanylate cyclase activity; integral to membrane; intracellular signal transduction; protein kinase activity IPR001054; IPR018297; IPR001828; IPR011009; IPR028082; IPR000719; IPR001245; Speract receptor (EC 4.6.1.2) (Guanylate cyclase) Strongylocentrotus purpuratus (Purple sea urchin) TR29558_c4_g1_i1 Q6GQ29 CBPQ_XENLA 1.00E-180 GO:0005794; GO:0004180; GO:0005783; GO:0005615; GO:0005764; GO:0046872; GO:0070573; GO:0043171; GO:0042803; GO:0006508 Golgi apparatus; carboxypeptidase activity; endoplasmic reticulum; extracellular space; lysosome; metal ion binding; metallodipeptidase activity; peptide catabolic process; protein homodimerization activity; proteolysis IPR007484; Carboxypeptidase Q (EC 3.4.17.-) (Plasma glutamate carboxypeptidase) cpq pgcp Xenopus laevis (African clawed frog) TR29558_c4_g1_i2 Q6GQ29 CBPQ_XENLA 1.00E-17 GO:0005794; GO:0004180; GO:0005783; GO:0005615; GO:0005764; GO:0046872; GO:0070573; GO:0043171; GO:0042803; GO:0006508 Golgi apparatus; carboxypeptidase activity; endoplasmic reticulum; extracellular space; lysosome; metal ion binding; metallodipeptidase activity; peptide catabolic process; protein homodimerization activity; proteolysis IPR007484; Carboxypeptidase Q (EC 3.4.17.-) (Plasma glutamate carboxypeptidase) cpq pgcp Xenopus laevis (African clawed frog) TR29562_c10_g1_i1 P08F94 PKHD1_HUMAN 6.00E-06 GO:0031362; GO:0016324; GO:0016337; GO:0005813; GO:0042384; GO:0005737; GO:0042592; GO:0016021; GO:0001822; GO:0005932; GO:0072686; GO:0051271; GO:0072372; GO:0004872; GO:0010824 anchored to external side of plasma membrane; apical plasma membrane; cell-cell adhesion; centrosome; cilium assembly; cytoplasm; homeostatic process; integral to membrane; kidney development; microtubule basal body; mitotic spindle; negative regulation of cellular component movement; primary cilium; receptor activity; regulation of centrosome duplication IPR019316; IPR013783; IPR014756; IPR002909; IPR006626; IPR012334; IPR011050; Fibrocystin (Polycystic kidney and hepatic disease 1 protein) (Polyductin) (Tigmin) PKHD1 FCYT TIGM1 Homo sapiens (Human) TR29562_c2_g1_i1 Q86WI1 PKHL1_HUMAN 4.00E-51 GO:0005829; GO:0005615; GO:0006955; GO:0016021; GO:0004872 cytosol; extracellular space; immune response; integral to membrane; receptor activity IPR008972; IPR019316; IPR013783; IPR014756; IPR002909; IPR011658; IPR006626; IPR011050; Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) PKHD1L1 Homo sapiens (Human) TR29562_c3_g1_i2 P08F94 PKHD1_HUMAN 2.00E-06 GO:0031362; GO:0016324; GO:0016337; GO:0005813; GO:0042384; GO:0005737; GO:0042592; GO:0016021; GO:0001822; GO:0005932; GO:0072686; GO:0051271; GO:0072372; GO:0004872; GO:0010824 anchored to external side of plasma membrane; apical plasma membrane; cell-cell adhesion; centrosome; cilium assembly; cytoplasm; homeostatic process; integral to membrane; kidney development; microtubule basal body; mitotic spindle; negative regulation of cellular component movement; primary cilium; receptor activity; regulation of centrosome duplication IPR019316; IPR013783; IPR014756; IPR002909; IPR006626; IPR012334; IPR011050; Fibrocystin (Polycystic kidney and hepatic disease 1 protein) (Polyductin) (Tigmin) PKHD1 FCYT TIGM1 Homo sapiens (Human) TR29562_c7_g1_i1 Q80ZA4 PKHL1_MOUSE 4.00E-17 GO:0016021 integral to membrane IPR008972; IPR019316; IPR013783; IPR014756; IPR002909; IPR011658; IPR006626; IPR011050; Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86) Pkhd1l1 Mus musculus (Mouse) TR29564_c0_g1_i3 Q6P298 NUBP1_DANRE 0 GO:0051539; GO:0005524; GO:0005829; GO:0016226; GO:0051536; GO:0046872; GO:0017111 "4 iron, 4 sulfur cluster binding; ATP binding; cytosol; iron-sulfur cluster assembly; iron-sulfur cluster binding; metal ion binding; nucleoside-triphosphatase activity" IPR003593; IPR025669; IPR019591; IPR000808; IPR027417; Cytosolic Fe-S cluster assembly factor nubp1 (Nucleotide-binding protein 1) (NBP 1) nubp1 zgc:92138 Danio rerio (Zebrafish) (Brachydanio rerio) TR29565_c0_g1_i2 Q5VUG0 SMBT2_HUMAN 4.00E-55 GO:0042393; GO:0010629; GO:0005634; GO:0006355 "histone binding; negative regulation of gene expression; nucleus; regulation of transcription, DNA-dependent" IPR021987; IPR004092; IPR001660; IPR013761; IPR021129; Scm-like with four MBT domains protein 2 (Scm-like with 4 MBT domains protein 2) SFMBT2 KIAA1617 Homo sapiens (Human) TR29565_c3_g1_i1 Q8N228 SCML4_HUMAN 5.00E-15 GO:0003677; GO:0005634; GO:0006355; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR017956; IPR021987; IPR001660; IPR013761; IPR021129; Sex comb on midleg-like protein 4 SCML4 Homo sapiens (Human) TR29565_c3_g2_i1 Q9UHJ3 SMBT1_HUMAN 3.00E-72 GO:0030154; GO:0016568; GO:0042393; GO:0048635; GO:0045892; GO:0005634; GO:0007283; GO:0003714; GO:0006351 Q16695 "cell differentiation; chromatin modification; histone binding; negative regulation of muscle organ development; negative regulation of transcription, DNA-dependent; nucleus; spermatogenesis; transcription corepressor activity; transcription, DNA-dependent" IPR021987; IPR004092; IPR001660; IPR013761; IPR021129; Scm-like with four MBT domains protein 1 (hSFMBT) (Renal ubiquitous protein 1) SFMBT1 RU1 Homo sapiens (Human) TR29569_c0_g1_i1 Q60716 P4HA2_MOUSE 4.00E-12 GO:0031418; GO:0005788; GO:0005506; GO:0016702; GO:0018401; GO:0004656 "L-ascorbic acid binding; endoplasmic reticulum lumen; iron ion binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; procollagen-proline 4-dioxygenase activity" IPR005123; IPR006620; IPR013547; IPR013026; IPR011990; IPR019734; "Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2)" P4ha2 Mus musculus (Mouse) TR29570_c3_g1_i1 Q7T6X2 YR826_MIMIV 4.00E-20 GO:0005524; GO:0009190; GO:0016021; GO:0035556; GO:0016849; GO:0004674 ATP binding; cyclic nucleotide biosynthetic process; integral to membrane; intracellular signal transduction; phosphorus-oxygen lyase activity; protein serine/threonine kinase activity IPR001054; IPR011009; IPR024370; IPR000719; IPR017441; IPR001245; IPR002290; IPR008271; Putative serine/threonine-protein kinase/receptor R826 (EC 2.7.11.1) MIMI_R826 Acanthamoeba polyphaga mimivirus (APMV) TR29571_c1_g1_i2 O14095 YERC_SCHPO 2.00E-42 GO:0045454; GO:0005829; GO:0009968; GO:0005634; GO:0006457; GO:0019236; GO:0072668 cell redox homeostasis; cytosol; negative regulation of signal transduction; nucleus; protein folding; response to pheromone; tubulin complex biogenesis IPR012336; IPR013766; Thioredoxin domain-containing protein plp1 (Phosducin-like protein 1) plp1 SPAC2F3.12c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR29572_c0_g2_i1 Q6P828 LITAF_XENTR 3.00E-19 GO:0005737; GO:0006355; GO:0006351 "cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) litaf TEgg087j16.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR29573_c1_g3_i1 Q04870 T2FA_XENLA 2.00E-48 GO:0003677; GO:0005634; GO:0045893; GO:0006367; GO:0016740 "DNA binding; nucleus; positive regulation of transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; transferase activity" IPR008851; IPR011039; IPR011991; General transcription factor IIF subunit 1 (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) gtf2f1 rap74 Xenopus laevis (African clawed frog) TR29579_c2_g1_i1 O88466 ZF106_MOUSE 1.00E-14 GO:0017124; GO:0005829; GO:0008286; GO:0016020; GO:0046872; GO:0005730 SH3 domain binding; cytosol; insulin receptor signaling pathway; membrane; metal ion binding; nucleolus IPR018391; IPR015943; IPR001680; IPR017986; IPR007087; IPR015880; Zinc finger protein 106 (Zfp-106) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant) (Zinc finger protein 474) Znf106 H3a Sh3bp3 Sirm Zfp106 Znf474 Mus musculus (Mouse) TR29580_c0_g1_i3 Q9PTU6 ENDOU_PAROL 2.00E-12 GO:0003723; GO:0004521; GO:0005576; GO:0006955; GO:0046872; GO:0030247; GO:0005044 RNA binding; endoribonuclease activity; extracellular region; immune response; metal ion binding; polysaccharide binding; scavenger receptor activity IPR018998; IPR020436; IPR001212; Poly(U)-specific endoribonuclease (EC 3.1.-.-) (Pancreatic protein with two somatomedin-B domains) (Protein endoU) (Uridylate-specific endoribonuclease) endou ppsb Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus) TR29583_c1_g1_i1 Q58D31 DHSO_BOVIN 2.00E-118 GO:0003939; GO:0051160; GO:0051287; GO:0046370; GO:0031966; GO:0031514; GO:0006062; GO:0030317; GO:0008270 L-iditol 2-dehydrogenase activity; L-xylitol catabolic process; NAD binding; fructose biosynthetic process; mitochondrial membrane; motile cilium; sorbitol catabolic process; sperm motility; zinc ion binding IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase) SORD Bos taurus (Bovine) TR29583_c1_g1_i2 Q29318 DHSO_PIG 5.00E-30 GO:0003939; GO:0031966; GO:0031514; GO:0030317; GO:0008270 L-iditol 2-dehydrogenase activity; mitochondrial membrane; motile cilium; sperm motility; zinc ion binding IPR013154; IPR002085; IPR002328; IPR011032; Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase) (Fragment) SORD Sus scrofa (Pig) TR29584_c0_g3_i1 P22680 CP7A1_HUMAN 2.00E-58 GO:0006699; GO:0044255; GO:0071397; GO:0071333; GO:0008123; GO:0006707; GO:0042632; GO:0005789; GO:0020037; GO:0005506; GO:0070857; GO:0006805 bile acid biosynthetic process; cellular lipid metabolic process; cellular response to cholesterol; cellular response to glucose stimulus; cholesterol 7-alpha-monooxygenase activity; cholesterol catabolic process; cholesterol homeostasis; endoplasmic reticulum membrane; heme binding; iron ion binding; regulation of bile acid biosynthetic process; xenobiotic metabolic process IPR001128; IPR017972; IPR024204; IPR002403; Lipid metabolism; bile acid biosynthesis. Cholesterol 7-alpha-monooxygenase (EC 1.14.13.17) (CYPVII) (Cholesterol 7-alpha-hydroxylase) (Cytochrome P450 7A1) CYP7A1 CYP7 Homo sapiens (Human) TR29588_c0_g1_i1 Q9M1Y0 ATG4B_ARATH 1.00E-27 GO:0006914; GO:0008234; GO:0005737; GO:0015031; GO:0006508 autophagy; cysteine-type peptidase activity; cytoplasm; protein transport; proteolysis IPR005078; Cysteine protease ATG4b (EC 3.4.22.-) (Autophagy-related protein 4 homolog b) (AtAPG4b) (Protein autophagy 4b) ATG4B APG4B At3g59950 F24G16.220 Arabidopsis thaliana (Mouse-ear cress) TR29588_c2_g1_i1 Q684M2 ATG4D_PIG 3.00E-55 GO:0006915; GO:0006914; GO:0008234; GO:0005759; GO:0015031; GO:0006508 apoptotic process; autophagy; cysteine-type peptidase activity; mitochondrial matrix; protein transport; proteolysis IPR005078; "Cysteine protease ATG4D (EC 3.4.22.-) (Autophagin-4) (Autophagy-related protein 4 homolog D) [Cleaved into: Cysteine protease ATG4D, mitochondrial]" ATG4D APG4D Sus scrofa (Pig) TR29588_c2_g1_i2 Q684M2 ATG4D_PIG 3.00E-55 GO:0006915; GO:0006914; GO:0008234; GO:0005759; GO:0015031; GO:0006508 apoptotic process; autophagy; cysteine-type peptidase activity; mitochondrial matrix; protein transport; proteolysis IPR005078; "Cysteine protease ATG4D (EC 3.4.22.-) (Autophagin-4) (Autophagy-related protein 4 homolog D) [Cleaved into: Cysteine protease ATG4D, mitochondrial]" ATG4D APG4D Sus scrofa (Pig) TR29590_c0_g3_i1 Q1JQ93 DPM1_BOVIN 7.00E-11 GO:0006506; GO:0004582; GO:0004169; GO:0005789; GO:0035269 GPI anchor biosynthetic process; dolichyl-phosphate beta-D-mannosyltransferase activity; dolichyl-phosphate-mannose-protein mannosyltransferase activity; endoplasmic reticulum membrane; protein O-linked mannosylation IPR001173; Protein modification; protein glycosylation. Dolichol-phosphate mannosyltransferase (EC 2.4.1.83) (Dolichol-phosphate mannose synthase) (DPM synthase) (Dolichyl-phosphate beta-D-mannosyltransferase) (Mannose-P-dolichol synthase) (MPD synthase) DPM1 Bos taurus (Bovine) TR29590_c1_g1_i1 Q9Y673 ALG5_HUMAN 1.00E-74 GO:0007368; GO:0006488; GO:0004581; GO:0005789; GO:0016021; GO:0004576; GO:0043687; GO:0018279 determination of left/right symmetry; dolichol-linked oligosaccharide biosynthetic process; dolichyl-phosphate beta-glucosyltransferase activity; endoplasmic reticulum membrane; integral to membrane; oligosaccharyl transferase activity; post-translational protein modification; protein N-linked glycosylation via asparagine IPR001173; Protein modification; protein glycosylation. Dolichyl-phosphate beta-glucosyltransferase (DolP-glucosyltransferase) (EC 2.4.1.117) (Asparagine-linked glycosylation protein 5 homolog) ALG5 HSPC149 Homo sapiens (Human) TR29590_c1_g1_i2 D4GUA0 AGLD_HALVD 2.00E-08 GO:0045232; GO:0016021; GO:0005886; GO:0016757 "S-layer organization; integral to membrane; plasma membrane; transferase activity, transferring glycosyl groups" IPR001173; IPR022791; Cell surface structure biogenesis; S-layer biogenesis. Glycosyltransferase AglD (EC 2.4.1.-) (Archaeal glycosylation protein D) aglD HVO_0798 Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) TR29592_c0_g1_i1 Q8BHE8 CB047_MOUSE 1.00E-20 GO:0005739 mitochondrion "Uncharacterized protein C2orf47 homolog, mitochondrial" Mus musculus (Mouse) TR29593_c0_g1_i2 Q7ZVZ6 PREP_DANRE 3.00E-68 GO:0046872; GO:0004222; GO:0005759; GO:0006508 metal ion binding; metalloendopeptidase activity; mitochondrial matrix; proteolysis IPR011249; IPR011237; IPR011765; IPR007863; IPR013578; "Presequence protease, mitochondrial (EC 3.4.24.-) (Pitrilysin metalloproteinase 1)" pitrm1 zgc:55469 Danio rerio (Zebrafish) (Brachydanio rerio) TR29596_c3_g1_i1 Q9MBF8 DYH1B_CHLRE 6.00E-09 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein-1-beta heavy chain, flagellar inner arm I1 complex (1-beta DHC) (Dynein-1, subspecies f)" DHC10 IDA2 Chlamydomonas reinhardtii (Chlamydomonas smithii) TR29596_c3_g1_i2 Q9MBF8 DYH1B_CHLRE 7.00E-09 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein-1-beta heavy chain, flagellar inner arm I1 complex (1-beta DHC) (Dynein-1, subspecies f)" DHC10 IDA2 Chlamydomonas reinhardtii (Chlamydomonas smithii) TR29597_c10_g1_i1 Q96N38 ZN714_HUMAN 1.00E-16 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 714 ZNF714 Homo sapiens (Human) TR29597_c10_g2_i1 Q8N2A0 CX062_HUMAN 1.00E-27 Putative uncharacterized protein encoded by LINC00269 LINC00269 CXorf62 NCRNA00269 Homo sapiens (Human) TR29597_c10_g2_i2 Q96CB5 CH044_HUMAN 2.00E-21 Putative uncharacterized protein C8orf44 C8orf44 Homo sapiens (Human) TR29597_c10_g3_i1 Q9H2J1 CI037_HUMAN 6.00E-11 IPR007677; Uncharacterized protein C9orf37 C9orf37 AD038 Homo sapiens (Human) TR29597_c9_g1_i1 Q86U02 CN165_HUMAN 5.00E-21 GO:0016021 integral to membrane Putative uncharacterized protein encoded by LINC00596 LINC00596 C14orf165 Homo sapiens (Human) TR29597_c9_g1_i2 Q6ZRH3 YA014_HUMAN 8.00E-06 Uncharacterized protein FLJ46360 Homo sapiens (Human) TR29598_c0_g1_i1 Q08347 BDS1_YEAST 3.00E-69 GO:0018741; GO:0004065; GO:0018909; GO:0032934 alkyl sulfatase activity; arylsulfatase activity; dodecyl sulfate metabolic process; sterol binding IPR001279; IPR003033; Alkyl/aryl-sulfatase BDS1 (EC 3.1.6.-) (Bacterially-derived sulfatase 1) BDS1 YOL164W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR29601_c1_g1_i4 A4IG66 TM201_DANRE 8.00E-24 GO:0016021 integral to membrane IPR018861; IPR018617; Transmembrane protein 201 tmem201 zgc:162289 Danio rerio (Zebrafish) (Brachydanio rerio) TR29603_c0_g1_i1 Q5R833 ACO13_PONAB 2.00E-40 GO:0016787; GO:0005739 hydrolase activity; mitochondrion IPR003736; IPR006683; "Acyl-coenzyme A thioesterase 13 (Acyl-CoA thioesterase 13) (EC 3.1.2.-) (Thioesterase superfamily member 2) [Cleaved into: Acyl-coenzyme A thioesterase 13, N-terminally processed]" ACOT13 THEM2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR29604_c0_g1_i1 Q2HJ27 MYC_BOVIN 7.00E-14 GO:0070888; GO:0000165; GO:0006919; GO:0006309; GO:0060070; GO:0007050; GO:0006879; GO:0034644; GO:0035690; GO:0006338; GO:0097193; GO:0043066; GO:0051782; GO:0048147; GO:0045656; GO:0032873; GO:0000122; GO:0016604; GO:0005730; GO:2000573; GO:0050679; GO:0048146; GO:2001022; GO:0045944; GO:0032403; GO:0032204; GO:0001836; GO:0006974; GO:0042493; GO:0010332; GO:0003700; GO:0005819; GO:0006351 "E-box binding; MAPK cascade; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic DNA fragmentation; canonical Wnt receptor signaling pathway; cell cycle arrest; cellular iron ion homeostasis; cellular response to UV; cellular response to drug; chromatin remodeling; intrinsic apoptotic signaling pathway; negative regulation of apoptotic process; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; nuclear body; nucleolus; positive regulation of DNA biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of response to DNA damage stimulus; positive regulation of transcription from RNA polymerase II promoter; protein complex binding; regulation of telomere maintenance; release of cytochrome c from mitochondria; response to DNA damage stimulus; response to drug; response to gamma radiation; sequence-specific DNA binding transcription factor activity; spindle; transcription, DNA-dependent" IPR011598; IPR003327; IPR002418; IPR012682; Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Bos taurus (Bovine) TR29604_c0_g1_i2 Q61976 MYCN_MARMO 1.00E-16 GO:0003677; GO:0005634; GO:0003700 DNA binding; nucleus; sequence-specific DNA binding transcription factor activity IPR011598; IPR002418; IPR012682; N-myc proto-oncogene protein (N-myc1) MYCN NMYC NMYC1 Marmota monax (Woodchuck) TR29605_c0_g1_i1 Q7T2B9 MTPN_DANRE 1.00E-10 GO:0005634; GO:0048471 nucleus; perinuclear region of cytoplasm IPR002110; IPR020683; Myotrophin mtpn Danio rerio (Zebrafish) (Brachydanio rerio) TR29605_c1_g1_i1 P23631 LATA_LATTR 2.00E-11 GO:0006887; GO:0016021; GO:0072556 exocytosis; integral to membrane; other organism presynaptic membrane IPR002110; IPR020683; IPR028047; Alpha-latrotoxin-Lt1a (Alpha-LTX-Lt1a) (Alpha-latrotoxin) (Alpha-LTX) Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus) TR29605_c1_g2_i1 Q8BTI7 ANR52_MOUSE 2.00E-09 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) Ankrd52 Mus musculus (Mouse) TR29606_c0_g1_i1 Q0P4Q4 FRMD3_XENTR 3.00E-54 GO:0005737; GO:0005856; GO:0019898; GO:0016021 cytoplasm; cytoskeleton; extrinsic to membrane; integral to membrane IPR019749; IPR019750; IPR000798; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; FERM domain-containing protein 3 frmd3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR29606_c0_g1_i2 Q9WV92 E41L3_MOUSE 7.00E-140 GO:0006915; GO:0005911; GO:0030866; GO:0030865; GO:0005737; GO:0007016; GO:0005856; GO:0019898; GO:0044224; GO:0043217; GO:0048812; GO:0030913; GO:0033270; GO:0005886; GO:0071205; GO:0002175; GO:0072659; GO:0008360; GO:0005200 apoptotic process; cell-cell junction; cortical actin cytoskeleton organization; cortical cytoskeleton organization; cytoplasm; cytoskeletal anchoring at plasma membrane; cytoskeleton; extrinsic to membrane; juxtaparanode region of axon; myelin maintenance; neuron projection morphogenesis; paranodal junction assembly; paranode region of axon; plasma membrane; protein localization to juxtaparanode region of axon; protein localization to paranode region of axon; protein localization to plasma membrane; regulation of cell shape; structural constituent of cytoskeleton IPR008379; IPR019749; IPR019750; IPR021187; IPR000798; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; IPR007477; "Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]" Epb41l3 Dal1 Epb4.1l3 Kiaa0987 Mus musculus (Mouse) TR29607_c0_g1_i1 Q9Y5W5 WIF1_HUMAN 1.00E-07 GO:0016055; GO:0005576; GO:0007275; GO:0045600; GO:0007165 P27467; P22725 Wnt receptor signaling pathway; extracellular region; multicellular organismal development; positive regulation of fat cell differentiation; signal transduction IPR000742; IPR013032; IPR003306; IPR013309; Wnt inhibitory factor 1 (WIF-1) WIF1 UNQ191/PRO217 Homo sapiens (Human) TR29607_c0_g1_i2 Q95LI2 VITRN_BOVIN 5.00E-18 GO:0005578 proteinaceous extracellular matrix IPR004043; IPR002035; Vitrin VIT Bos taurus (Bovine) TR29607_c0_g1_i3 Q923P0 COKA1_MOUSE 1.00E-20 GO:0005581; GO:0005615 collagen; extracellular space IPR008160; IPR008985; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XX) chain Col20a1 Mus musculus (Mouse) TR29607_c0_g1_i4 Q9P218 COKA1_HUMAN 5.00E-18 GO:0005581; GO:0005788; GO:0030198; GO:0005576; GO:0005615 collagen; endoplasmic reticulum lumen; extracellular matrix organization; extracellular region; extracellular space IPR008160; IPR008985; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XX) chain COL20A1 KIAA1510 Homo sapiens (Human) TR29607_c0_g1_i5 Q923P0 COKA1_MOUSE 9.00E-21 GO:0005581; GO:0005615 collagen; extracellular space IPR008160; IPR008985; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XX) chain Col20a1 Mus musculus (Mouse) TR29608_c0_g1_i2 Q6PDJ1 CAHD1_MOUSE 2.00E-94 GO:0006816; GO:0016021 calcium ion transport; integral to membrane IPR004010; IPR013608; IPR002035; VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) TR29615_c0_g2_i1 O00602 FCN1_HUMAN 9.00E-49 GO:0003823; GO:0005509; GO:0030246; GO:0005581; GO:0001867; GO:0005576; GO:0008228 Q2TS39 "antigen binding; calcium ion binding; carbohydrate binding; collagen; complement activation, lectin pathway; extracellular region; opsonization" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) FCN1 FCNM Homo sapiens (Human) TR29616_c2_g1_i3 B0BN95 HARB1_RAT 7.00E-19 GO:0005813; GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 centrosome; cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) Harbi1 Rattus norvegicus (Rat) TR29616_c2_g2_i3 Q8BR93 HARB1_MOUSE 4.00E-13 GO:0005813; GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 centrosome; cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) Harbi1 Mus musculus (Mouse) TR29619_c0_g1_i1 Q5F478 ANR44_CHICK 1.00E-17 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) TR29620_c0_g1_i1 O75366 AVIL_HUMAN 7.00E-68 GO:0003779; GO:0015629; GO:0051693; GO:0030424; GO:0060271; GO:0005737; GO:0007010; GO:0043005; GO:0010976; GO:0006950 actin binding; actin cytoskeleton; actin filament capping; axon; cilium morphogenesis; cytoplasm; cytoskeleton organization; neuron projection; positive regulation of neuron projection development; response to stress IPR007123; IPR007122; IPR003128; Advillin (p92) AVIL Homo sapiens (Human) TR29620_c0_g1_i2 Q29297 ADSV_PIG 1.00E-25 GO:0051693; GO:0032330 actin filament capping; regulation of chondrocyte differentiation IPR007123; IPR007122; Adseverin (Scinderin) (Fragment) SCIN Sus scrofa (Pig) TR29621_c1_g2_i2 Q58377 Y967_METJA 8.00E-20 GO:0016798 "hydrolase activity, acting on glycosyl bonds" IPR006286; IPR002818; Uncharacterized protein MJ0967 MJ0967 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR29621_c1_g2_i3 P80876 GS18_BACSU 4.00E-36 GO:0016798; GO:0008233; GO:0006508; GO:0006950 "hydrolase activity, acting on glycosyl bonds; peptidase activity; proteolysis; response to stress" IPR006286; IPR002818; General stress protein 18 (GSP18) (EC 3.2.-.-) yfkM BSU07850 Bacillus subtilis (strain 168) TR29621_c1_g2_i5 O28987 Y1281_ARCFU 1.00E-46 GO:0016798 "hydrolase activity, acting on glycosyl bonds" IPR006286; IPR002818; Uncharacterized protein AF_1281 AF_1281 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) TR29622_c0_g1_i2 Q13202 DUS8_HUMAN 2.00E-94 GO:0017017; GO:0005737; GO:0005634; GO:0004725 MAP kinase tyrosine/serine/threonine phosphatase activity; cytoplasm; nucleus; protein tyrosine phosphatase activity IPR000340; IPR020422; IPR024950; IPR008343; IPR001763; IPR000387; IPR016130; Dual specificity protein phosphatase 8 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH-5) DUSP8 C11orf81 VH5 Homo sapiens (Human) TR29624_c0_g1_i1 P50224 ST1A3_HUMAN 1.00E-30 GO:0050427; GO:0006987; GO:0004062; GO:0006584; GO:0044267; GO:0005829; GO:0009812; GO:0008202; GO:0051923; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; activation of signaling protein activity involved in unfolded protein response; aryl sulfotransferase activity; catecholamine metabolic process; cellular protein metabolic process; cytosol; flavonoid metabolic process; steroid metabolic process; sulfation; xenobiotic metabolic process IPR027417; IPR000863; "Sulfotransferase 1A3/1A4 (ST1A3/ST1A4) (EC 2.8.2.1) (Aryl sulfotransferase 1A3/1A4) (Catecholamine-sulfating phenol sulfotransferase) (HAST3) (M-PST) (Monoamine-sulfating phenol sulfotransferase) (Placental estrogen sulfotransferase) (Sulfotransferase, monoamine-preferring) (Thermolabile phenol sulfotransferase) (TL-PST)" SULT1A3 STM; SULT1A4 Homo sapiens (Human) TR29626_c0_g1_i1 Q6DFV8 VWDE_MOUSE 5.00E-06 GO:0005576 extracellular region IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) TR29627_c0_g2_i1 A2RU67 K1467_HUMAN 1.00E-07 GO:0016021 integral to membrane IPR027295; IPR011047; Uncharacterized protein KIAA1467 KIAA1467 Homo sapiens (Human) TR29628_c1_g1_i1 Q58DT0 ELF5_BOVIN 6.00E-29 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; ETS-related transcription factor Elf-5 (E74-like factor 5) ELF5 Bos taurus (Bovine) TR29629_c0_g1_i1 Q9Z2P6 SNP29_RAT 7.00E-21 GO:0031201; GO:0000046; GO:0030054; GO:0043005; GO:0015031; GO:0045202 Q641Z6; Q9EQP2 SNARE complex; autophagic vacuole fusion; cell junction; neuron projection; protein transport; synapse IPR000928; IPR000727; Synaptosomal-associated protein 29 (SNAP-29) (Golgi SNARE of 32 kDa) (Gs32) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) Snap29 Rattus norvegicus (Rat) TR29630_c0_g1_i1 P37137 LHX5_XENLA 7.00E-105 GO:0007275; GO:0005634; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR017970; IPR001356; IPR009057; IPR001781; LIM/homeobox protein Lhx5 (LIM homeobox protein 5) (Homeobox protein LIM-5) (xLIM-5) (xLIM-2A) lhx5 lim2a lim5 Xenopus laevis (African clawed frog) TR29633_c0_g1_i1 P05090 APOD_HUMAN 5.00E-19 GO:0007568; GO:0001525; GO:0007420; GO:0015485; GO:0022626; GO:0030425; GO:0005783; GO:0005615; GO:0006006; GO:0006629; GO:0005319; GO:2000405; GO:1900016; GO:0051895; GO:0060588; GO:0071638; GO:0010642; GO:0042308; GO:0048662; GO:2000098; GO:0043025; GO:0048471; GO:0014012; GO:0042493; GO:0000302; GO:0042246 aging; angiogenesis; brain development; cholesterol binding; cytosolic ribosome; dendrite; endoplasmic reticulum; extracellular space; glucose metabolic process; lipid metabolic process; lipid transporter activity; negative regulation of T cell migration; negative regulation of cytokine production involved in inflammatory response; negative regulation of focal adhesion assembly; negative regulation of lipoprotein lipid oxidation; negative regulation of monocyte chemotactic protein-1 production; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein import into nucleus; negative regulation of smooth muscle cell proliferation; negative regulation of smooth muscle cell-matrix adhesion; neuronal cell body; perinuclear region of cytoplasm; peripheral nervous system axon regeneration; response to drug; response to reactive oxygen species; tissue regeneration IPR026222; IPR002969; IPR012674; IPR011038; IPR002345; IPR022271; IPR022272; IPR000566; Apolipoprotein D (Apo-D) (ApoD) APOD Homo sapiens (Human) TR29633_c0_g1_i2 P51909 APOD_CAVPO 2.00E-16 GO:0007568; GO:0007420; GO:0015485; GO:0022626; GO:0030425; GO:0005783; GO:0005615; GO:0006006; GO:0006629; GO:2000405; GO:1900016; GO:0051895; GO:0060588; GO:0071638; GO:0010642; GO:0042308; GO:0048662; GO:2000098; GO:0043025; GO:0048471; GO:0014012; GO:0042493; GO:0000302; GO:0042246; GO:0005215 aging; brain development; cholesterol binding; cytosolic ribosome; dendrite; endoplasmic reticulum; extracellular space; glucose metabolic process; lipid metabolic process; negative regulation of T cell migration; negative regulation of cytokine production involved in inflammatory response; negative regulation of focal adhesion assembly; negative regulation of lipoprotein lipid oxidation; negative regulation of monocyte chemotactic protein-1 production; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein import into nucleus; negative regulation of smooth muscle cell proliferation; negative regulation of smooth muscle cell-matrix adhesion; neuronal cell body; perinuclear region of cytoplasm; peripheral nervous system axon regeneration; response to drug; response to reactive oxygen species; tissue regeneration; transporter activity IPR026222; IPR002969; IPR012674; IPR011038; IPR022271; IPR022272; IPR000566; Apolipoprotein D (Apo-D) (ApoD) APOD Cavia porcellus (Guinea pig) TR29633_c0_g2_i3 P37153 APOD_RABIT 7.00E-17 GO:0007568; GO:0007420; GO:0015485; GO:0022626; GO:0030425; GO:0005783; GO:0005615; GO:0006006; GO:0006629; GO:2000405; GO:1900016; GO:0051895; GO:0060588; GO:0071638; GO:0010642; GO:0042308; GO:0048662; GO:2000098; GO:0043025; GO:0048471; GO:0014012; GO:0042493; GO:0000302; GO:0042246; GO:0005215 aging; brain development; cholesterol binding; cytosolic ribosome; dendrite; endoplasmic reticulum; extracellular space; glucose metabolic process; lipid metabolic process; negative regulation of T cell migration; negative regulation of cytokine production involved in inflammatory response; negative regulation of focal adhesion assembly; negative regulation of lipoprotein lipid oxidation; negative regulation of monocyte chemotactic protein-1 production; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein import into nucleus; negative regulation of smooth muscle cell proliferation; negative regulation of smooth muscle cell-matrix adhesion; neuronal cell body; perinuclear region of cytoplasm; peripheral nervous system axon regeneration; response to drug; response to reactive oxygen species; tissue regeneration; transporter activity IPR026222; IPR002969; IPR012674; IPR011038; IPR022271; IPR022272; IPR000566; Apolipoprotein D (Apo-D) (ApoD) APOD Oryctolagus cuniculus (Rabbit) TR29635_c0_g2_i1 Q84L30 RD23D_ARATH 1.00E-07 GO:0005829; GO:0003684; GO:0006289; GO:0005634; GO:0031593; GO:0043161; GO:0070628; GO:0009409 cytosol; damaged DNA binding; nucleotide-excision repair; nucleus; polyubiquitin binding; proteasomal ubiquitin-dependent protein catabolic process; proteasome binding; response to cold IPR004806; IPR006636; IPR009060; IPR015940; IPR000449; IPR000626; IPR015360; Ubiquitin receptor RAD23d (AtRAD23d) (Putative DNA repair protein RAD23-4) (RAD23-like protein 4) (AtRAD23-4) RAD23D RAD23 RAD23-4 At5g38470 MXI10.20 Arabidopsis thaliana (Mouse-ear cress) TR29635_c0_g2_i2 P0CG60 UBB_PONPY 8.00E-92 GO:0005737; GO:0005634 cytoplasm; nucleus IPR019956; IPR019954; IPR000626; Polyubiquitin-B [Cleaved into: Ubiquitin] UBB Pongo pygmaeus (Bornean orangutan) TR29635_c0_g2_i3 P69326 UBIQ_WHEAT 8.00E-44 GO:0005737; GO:0005634 cytoplasm; nucleus IPR019956; IPR019954; IPR000626; Ubiquitin Triticum aestivum (Wheat) TR29635_c0_g2_i4 P0C073 RUB1_DESAN 4.00E-57 GO:0005737; GO:0005634 cytoplasm; nucleus IPR019956; IPR019954; IPR000626; Ubiquitin-NEDD8-like protein RUB1 [Cleaved into: Ubiquitin; NEDD8-like protein RUB1 (DaRUB1) (Ubiquitin-related protein 1)] RUB1 Deschampsia antarctica (Antarctic hairgrass) TR29635_c0_g2_i5 P23398 UBIQP_STRPU 3.00E-67 GO:0005737; GO:0005634 cytoplasm; nucleus IPR019956; IPR019954; IPR000626; Polyubiquitin [Cleaved into: Ubiquitin] (Fragment) Strongylocentrotus purpuratus (Purple sea urchin) TR29636_c0_g1_i5 Q9H6L4 ARMC7_HUMAN 2.00E-71 IPR011989; IPR016024; IPR000225; Armadillo repeat-containing protein 7 ARMC7 Homo sapiens (Human) TR29637_c1_g1_i1 B7ZS37 BAZ2A_XENLA 1.00E-76 GO:0003677; GO:0006306; GO:0003723; GO:0000183; GO:0005677; GO:0070577; GO:0016575; GO:0005730; GO:0033553; GO:0006351; GO:0008270 "DNA binding; DNA methylation; RNA binding; chromatin silencing at rDNA; chromatin silencing complex; histone acetyl-lysine binding; histone deacetylation; nucleolus; rDNA heterochromatin; transcription, DNA-dependent; zinc ion binding" IPR017956; IPR001487; IPR018359; IPR004022; IPR018501; IPR016177; IPR001739; IPR011011; IPR001965; IPR019787; IPR013083; Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) baz2a tip5 Xenopus laevis (African clawed frog) TR29637_c2_g1_i2 Q9UIF8 BAZ2B_HUMAN 1.00E-17 GO:0003677; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001487; IPR018359; IPR004022; IPR018500; IPR018501; IPR016177; IPR001739; IPR011011; IPR001965; IPR019787; IPR013083; Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) BAZ2B KIAA1476 Homo sapiens (Human) TR29638_c2_g1_i3 Q9Y5K6 CD2AP_HUMAN 2.00E-06 GO:0051301; GO:0005737; GO:0031941; GO:0007067; GO:0005730; GO:0005886; GO:0006461; GO:0001726; GO:0007165; GO:0005200; GO:0006930 Q8WV28; P22681; Q13191; P06729; P62993; P46940; Q8WUM4; Q99816 "cell division; cytoplasm; filamentous actin; mitosis; nucleolus; plasma membrane; protein complex assembly; ruffle; signal transduction; structural constituent of cytoskeleton; substrate-dependent cell migration, cell extension" IPR001452; CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) CD2AP Homo sapiens (Human) TR29638_c3_g2_i1 Q8QFX1 RIMB2_CHICK 2.00E-35 GO:0030054; GO:0010923; GO:0005886; GO:0045202 cell junction; negative regulation of phosphatase activity; plasma membrane; synapse IPR003961; IPR013783; IPR011511; IPR001452; RIMS-binding protein 2 (RIM-BP2) RIMBP2 RBP2 Gallus gallus (Chicken) TR29639_c10_g2_i1 Q9CR88 RT14_MOUSE 2.00E-10 GO:0005763; GO:0031965; GO:0003735; GO:0006412 mitochondrial small ribosomal subunit; nuclear membrane; structural constituent of ribosome; translation IPR001209; "28S ribosomal protein S14, mitochondrial (MRP-S14) (S14mt)" Mrps14 Mus musculus (Mouse) TR29639_c10_g2_i2 Q9CR88 RT14_MOUSE 8.00E-10 GO:0005763; GO:0031965; GO:0003735; GO:0006412 mitochondrial small ribosomal subunit; nuclear membrane; structural constituent of ribosome; translation IPR001209; "28S ribosomal protein S14, mitochondrial (MRP-S14) (S14mt)" Mrps14 Mus musculus (Mouse) TR29639_c7_g1_i1 Q5NVA9 EME1_PONAB 5.00E-50 GO:0003677; GO:0006310; GO:0006281; GO:0004519; GO:0046872; GO:0090305; GO:0005730 DNA binding; DNA recombination; DNA repair; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleolus IPR006166; Crossover junction endonuclease EME1 (EC 3.1.22.-) EME1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR29639_c8_g2_i1 Q5P7Z5 RL27_AROAE 1.00E-08 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001684; IPR018261; 50S ribosomal protein L27 rpmA AZOSEA04440 ebC2 Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) TR29640_c2_g1_i4 P35590 TIE1_HUMAN 5.00E-10 GO:0005524; GO:0001525; GO:0001701; GO:0005887; GO:0007498; GO:0016525; GO:0030336; GO:0045026; GO:0032526; GO:0004714 Q15238 ATP binding; angiogenesis; in utero embryonic development; integral to plasma membrane; mesoderm development; negative regulation of angiogenesis; negative regulation of cell migration; plasma membrane fusion; response to retinoic acid; transmembrane receptor protein tyrosine kinase activity IPR000742; IPR013032; IPR003961; IPR013783; IPR003599; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE Homo sapiens (Human) TR29642_c2_g1_i3 Q8R033 LYRM2_MOUSE 1.00E-17 GO:0005739 mitochondrion IPR008011; IPR026868; LYR motif-containing protein 2 Lyrm2 Mus musculus (Mouse) TR29645_c1_g1_i2 Q8N4P6 LRC71_HUMAN 4.00E-31 Leucine-rich repeat-containing protein 71 LRRC71 C1orf92 Homo sapiens (Human) TR29646_c0_g1_i1 Q75C39 DBP5_ASHGO 1.00E-120 GO:0005524; GO:0008026; GO:0003723; GO:0005737; GO:0051028; GO:0031965; GO:0005643; GO:0015031 ATP binding; ATP-dependent helicase activity; RNA binding; cytoplasm; mRNA transport; nuclear membrane; nuclear pore; protein transport IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DBP5 (EC 3.6.4.13) DBP5 ACR078W Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR29646_c0_g1_i2 Q6BRE4 DBP5_DEBHA 2.00E-120 GO:0005524; GO:0008026; GO:0003723; GO:0005737; GO:0051028; GO:0031965; GO:0005643; GO:0015031 ATP binding; ATP-dependent helicase activity; RNA binding; cytoplasm; mRNA transport; nuclear membrane; nuclear pore; protein transport IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DBP5 (EC 3.6.4.13) DBP5 DEHA2D17072g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR29646_c0_g1_i3 Q3ZBV2 DD19A_BOVIN 0 GO:0005524; GO:0008026; GO:0003723; GO:0005737; GO:0051028; GO:0031965; GO:0005643; GO:0015031 ATP binding; ATP-dependent helicase activity; RNA binding; cytoplasm; mRNA transport; nuclear membrane; nuclear pore; protein transport IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; ATP-dependent RNA helicase DDX19A (EC 3.6.4.13) (DEAD box protein 19A) DDX19A Bos taurus (Bovine) TR29646_c0_g1_i4 Q58Z64 DHH1_CRYNV 1.00E-51 GO:0005524; GO:0008026; GO:0003723; GO:0000932; GO:0006397; GO:0051028; GO:0006417 ATP binding; ATP-dependent helicase activity; RNA binding; cytoplasmic mRNA processing body; mRNA processing; mRNA transport; regulation of translation IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase VAD1 (EC 3.6.4.13) (Virulence-associated DEAD box protein 1) VAD1 DHH1 CNAG_01537 Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) TR29646_c0_g1_i5 Q3ZBV2 DD19A_BOVIN 0 GO:0005524; GO:0008026; GO:0003723; GO:0005737; GO:0051028; GO:0031965; GO:0005643; GO:0015031 ATP binding; ATP-dependent helicase activity; RNA binding; cytoplasm; mRNA transport; nuclear membrane; nuclear pore; protein transport IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; ATP-dependent RNA helicase DDX19A (EC 3.6.4.13) (DEAD box protein 19A) DDX19A Bos taurus (Bovine) TR29649_c0_g1_i1 Q9W107 SYYM_DROME 4.00E-162 GO:0005524; GO:0003723; GO:0005759; GO:0004831; GO:0006437 ATP binding; RNA binding; mitochondrial matrix; tyrosine-tRNA ligase activity; tyrosyl-tRNA aminoacylation IPR001412; IPR002305; IPR014729; IPR002942; IPR002307; IPR024088; IPR024107; "Probable tyrosine--tRNA ligase, mitochondrial (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)" CG16912 Drosophila melanogaster (Fruit fly) TR29649_c0_g1_i2 P12063 SYYM_NEUCR 2.00E-65 GO:0005524; GO:0003723; GO:0006397; GO:0005759; GO:0004831; GO:0006437 ATP binding; RNA binding; mRNA processing; mitochondrial matrix; tyrosine-tRNA ligase activity; tyrosyl-tRNA aminoacylation IPR001412; IPR002305; IPR014729; IPR002942; IPR002307; IPR024088; "Tyrosine--tRNA ligase, mitochondrial (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)" cyt-18 B18P24.070 NCU03030 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR29650_c0_g3_i1 Q5RAA9 NPS3A_PONAB 1.00E-24 GO:0005829 cytosol IPR011008; IPR012577; Protein NipSnap homolog 3A (NipSnap3A) NIPSNAP3A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR29651_c1_g1_i1 Q5BJ29 FBXL7_MOUSE 9.00E-138 GO:0000086; GO:0019005; GO:0031146; GO:0051301; GO:0008283; GO:0005813; GO:0005737; GO:0007067; GO:0016567 G2/M transition of mitotic cell cycle; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; cell proliferation; centrosome; cytoplasm; mitosis; protein ubiquitination IPR001810; IPR006553; Protein modification; protein ubiquitination. F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) Fbxl7 Kiaa0840 Mus musculus (Mouse) TR29652_c0_g2_i1 Q96MM6 HS12B_HUMAN 1.00E-52 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR29655_c2_g2_i1 Q17778 NUC1_CAEEL 9.00E-32 GO:0006309; GO:0004531; GO:0005764; GO:0005634 apoptotic DNA fragmentation; deoxyribonuclease II activity; lysosome; nucleus IPR004947; Deoxyribonuclease-2 (EC 3.1.22.1) (Deoxyribonuclease II) (DNase II) nuc-1 C07B5.5 Caenorhabditis elegans TR29655_c2_g3_i1 Q75WF2 DNA2_ACAPL 9.00E-43 GO:0006259; GO:0006915; GO:0004531; GO:0005576; GO:0090305 DNA metabolic process; apoptotic process; deoxyribonuclease II activity; extracellular region; nucleic acid phosphodiester bond hydrolysis IPR004947; Plancitoxin-1 (EC 3.1.22.1) (Plancitoxin I) (Plan-I) [Cleaved into: Plancitoxin-1 subunit alpha; Plancitoxin-1 subunit beta] Acanthaster planci (Crown-of-thorns starfish) TR29658_c3_g1_i1 P59110 SENP1_MOUSE 6.00E-88 GO:0016929; GO:0006919; GO:0097190; GO:0005737; GO:0007275; GO:0032435; GO:0005634; GO:0045944; GO:0016926; GO:0006508; GO:0010724 SUMO-specific protease activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic signaling pathway; cytoplasm; multicellular organismal development; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; nucleus; positive regulation of transcription from RNA polymerase II promoter; protein desumoylation; proteolysis; regulation of definitive erythrocyte differentiation IPR003653; Sentrin-specific protease 1 (EC 3.4.22.68) (SUMO-1 protease 2) (SuPr-2) (Sentrin/SUMO-specific protease SENP1) Senp1 Supr2 Mus musculus (Mouse) TR29659_c0_g1_i3 Q8C6U2 PQLC3_MOUSE 1.00E-32 GO:0016021 integral to membrane IPR006603; IPR016817; PQ-loop repeat-containing protein 3 Pqlc3 Mus musculus (Mouse) TR29660_c0_g1_i1 Q6P1Z5 PED1A_MOUSE 2.00E-65 IPR026057; PC-esterase domain-containing protein 1A (Protein FAM113A) Pced1a Fam113a Mus musculus (Mouse) TR29660_c0_g1_i3 Q6P1Z5 PED1A_MOUSE 2.00E-67 IPR026057; PC-esterase domain-containing protein 1A (Protein FAM113A) Pced1a Fam113a Mus musculus (Mouse) TR29661_c0_g2_i1 A1L3G4 TM241_XENLA 2.00E-52 GO:0016021 integral to membrane Transmembrane protein 241 tmem241 Xenopus laevis (African clawed frog) TR29662_c0_g1_i1 Q10651 A4_CAEEL 2.00E-32 GO:0010171; GO:0030154; GO:0031410; GO:0042395; GO:0008201; GO:0016021; GO:0002119; GO:0007399; GO:0043005; GO:0043025; GO:0046914 "body morphogenesis; cell differentiation; cytoplasmic vesicle; ecdysis, collagen and cuticulin-based cuticle; heparin binding; integral to membrane; nematode larval development; nervous system development; neuron projection; neuronal cell body; transition metal ion binding" IPR008155; IPR011178; IPR024329; IPR008154; IPR019744; IPR015849; IPR019543; Beta-amyloid-like protein apl-1 C42D8.8 Caenorhabditis elegans TR29664_c0_g1_i1 Q9CPU4 MGST3_MOUSE 3.00E-23 GO:0005783; GO:0005789; GO:0004602; GO:0004364; GO:0016021; GO:0005635 endoplasmic reticulum; endoplasmic reticulum membrane; glutathione peroxidase activity; glutathione transferase activity; integral to membrane; nuclear envelope IPR023352; IPR001129; Microsomal glutathione S-transferase 3 (Microsomal GST-3) (EC 2.5.1.18) (Microsomal GST-III) Mgst3 Mus musculus (Mouse) TR29665_c1_g1_i1 E1C213 UBP37_CHICK 1.00E-35 GO:0000082; GO:0051301; GO:0004197; GO:0007067; GO:0035871; GO:0071108; GO:0004221; GO:0006511; GO:0004843 G1/S transition of mitotic cell cycle; cell division; cysteine-type endopeptidase activity; mitosis; protein K11-linked deubiquitination; protein K48-linked deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR018200; IPR001394; IPR003903; Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) USP37 Gallus gallus (Chicken) TR29665_c5_g1_i2 Q9HBJ7 UBP29_HUMAN 3.00E-17 GO:0006464; GO:0008234; GO:0004221; GO:0006511 cellular protein modification process; cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.4.19.12) (Deubiquitinating enzyme 29) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29) USP29 Homo sapiens (Human) TR29666_c0_g1_i1 Q91WG1 INSI2_MOUSE 2.00E-82 GO:0032933; GO:0032937; GO:0006695; GO:0060363; GO:0042472; GO:0042474; GO:0045717; GO:0010894; GO:0060021; GO:0070542; GO:0032868; GO:0006991; GO:0006641 SREBP signaling pathway; SREBP-SCAP-Insig complex; cholesterol biosynthetic process; cranial suture morphogenesis; inner ear morphogenesis; middle ear morphogenesis; negative regulation of fatty acid biosynthetic process; negative regulation of steroid biosynthetic process; palate development; response to fatty acid; response to insulin stimulus; response to sterol depletion; triglyceride metabolic process IPR009904; IPR025929; Insulin-induced gene 2 protein (INSIG-2) Insig2 Mus musculus (Mouse) TR29666_c0_g1_i2 Q91WG1 INSI2_MOUSE 2.00E-82 GO:0032933; GO:0032937; GO:0006695; GO:0060363; GO:0042472; GO:0042474; GO:0045717; GO:0010894; GO:0060021; GO:0070542; GO:0032868; GO:0006991; GO:0006641 SREBP signaling pathway; SREBP-SCAP-Insig complex; cholesterol biosynthetic process; cranial suture morphogenesis; inner ear morphogenesis; middle ear morphogenesis; negative regulation of fatty acid biosynthetic process; negative regulation of steroid biosynthetic process; palate development; response to fatty acid; response to insulin stimulus; response to sterol depletion; triglyceride metabolic process IPR009904; IPR025929; Insulin-induced gene 2 protein (INSIG-2) Insig2 Mus musculus (Mouse) TR29672_c0_g1_i2 O88561 S27A3_MOUSE 3.00E-118 GO:0006637; GO:0004321; GO:0016021; GO:0004467; GO:0005739; GO:0000166 acyl-CoA metabolic process; fatty-acyl-CoA synthase activity; integral to membrane; long-chain fatty acid-CoA ligase activity; mitochondrion; nucleotide binding IPR025110; IPR020845; IPR000873; Long-chain fatty acid transport protein 3 (FATP-3) (Fatty acid transport protein 3) (EC 6.2.1.-) (Solute carrier family 27 member 3) Slc27a3 Acsvl3 Fatp3 Mus musculus (Mouse) TR29672_c0_g1_i5 O88561 S27A3_MOUSE 3.00E-26 GO:0006637; GO:0004321; GO:0016021; GO:0004467; GO:0005739; GO:0000166 acyl-CoA metabolic process; fatty-acyl-CoA synthase activity; integral to membrane; long-chain fatty acid-CoA ligase activity; mitochondrion; nucleotide binding IPR025110; IPR020845; IPR000873; Long-chain fatty acid transport protein 3 (FATP-3) (Fatty acid transport protein 3) (EC 6.2.1.-) (Solute carrier family 27 member 3) Slc27a3 Acsvl3 Fatp3 Mus musculus (Mouse) TR29673_c0_g2_i1 P85831 PROH4_APIME 3.00E-18 GO:0005576 extracellular region IPR023415; IPR002172; Prohormone-4 [Cleaved into: Brain peptide IDLSRFYGHFNT; Brain peptide IDLSRFYGHFN; Brain peptide IDLSRFYGHF; Brain peptide DLSRFYGHFNT; Brain peptide DLSRFYGHFN; Brain peptide DLSRFYGHF] Apis mellifera (Honeybee) TR29675_c8_g1_i1 O35386 PAHX_MOUSE 3.00E-07 GO:0031418; GO:0003824; GO:0048037; GO:0001561; GO:0006720; GO:0046872; GO:0097089; GO:0005739; GO:0005777; GO:0048244 L-ascorbic acid binding; catalytic activity; cofactor binding; fatty acid alpha-oxidation; isoprenoid metabolic process; metal ion binding; methyl-branched fatty acid metabolic process; mitochondrion; peroxisome; phytanoyl-CoA dioxygenase activity IPR008775; Lipid metabolism; fatty acid metabolism. "Phytanoyl-CoA dioxygenase, peroxisomal (EC 1.14.11.18) (Lupus nephritis-associated peptide 1) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH)" Phyh Ln1 Lnap1 Pahx Mus musculus (Mouse) TR29675_c8_g1_i2 Q7W977 ECTD_BORPA 9.00E-11 GO:0016725 "oxidoreductase activity, acting on CH or CH2 groups" IPR012774; IPR008775; Ectoine hydroxylase (EC 1.17.-.-) ectD BPP1891 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) TR29678_c0_g2_i1 Q9H8Y5 ANKZ1_HUMAN 4.00E-17 GO:0046872 Q9Q2G4 metal ion binding IPR002110; IPR020683; IPR007087; IPR015880; Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744) ANKZF1 ZNF744 Homo sapiens (Human) TR29678_c1_g1_i1 Q66H85 ANKZ1_RAT 3.00E-18 GO:0046872 metal ion binding IPR002110; IPR020683; IPR007087; IPR015880; Ankyrin repeat and zinc finger domain-containing protein 1 Ankzf1 Rattus norvegicus (Rat) TR29679_c1_g1_i2 Q9U518 ASPG_DIRIM 6.00E-11 GO:0004067; GO:0006528 asparaginase activity; asparagine metabolic process IPR002110; IPR020683; IPR006033; IPR006034; IPR020827; IPR027475; IPR027473; IPR027474; L-asparaginase (EC 3.5.1.1) (DiAsp) (L-asparagine amidohydrolase) Dirofilaria immitis (Canine heartworm) TR29680_c1_g1_i1 Q17237 SGF3_BOMMO 1.00E-97 GO:0030154; GO:0007399; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "cell differentiation; nervous system development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; IPR010982; IPR013847; IPR000327; Silk gland factor 3 (SGF-3) (POU domain protein M1) SGF3 POU-M1 Bombyx mori (Silk moth) TR29680_c1_g1_i2 Q17237 SGF3_BOMMO 2.00E-96 GO:0030154; GO:0007399; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "cell differentiation; nervous system development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; IPR010982; IPR013847; IPR000327; Silk gland factor 3 (SGF-3) (POU domain protein M1) SGF3 POU-M1 Bombyx mori (Silk moth) TR29682_c0_g1_i1 Q2KI15 RF1ML_BOVIN 6.00E-97 GO:0005739; GO:0016149 "mitochondrion; translation release factor activity, codon specific" IPR014720; IPR005139; IPR000352; "Peptide chain release factor 1-like, mitochondrial (Mitochondrial translational release factor 1-like)" MTRF1L Bos taurus (Bovine) TR29683_c3_g1_i1 Q9P802 MIS18_SCHPO 1.00E-07 GO:0031511; GO:0051301; GO:0031055; GO:0000778; GO:0005737; GO:0016575; GO:0051382; GO:0000070; GO:0034501; GO:0031066 O94244 Mis6-Sim4 complex; cell division; chromatin remodeling at centromere; condensed nuclear chromosome kinetochore; cytoplasm; histone deacetylation; kinetochore assembly; mitotic sister chromatid segregation; protein localization to kinetochore; regulation of histone deacetylation at centromere IPR004910; Kinetochore protein mis18 mis18 SPCC970.12 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR29684_c1_g1_i1 Q8TC12 RDH11_HUMAN 4.00E-63 GO:0052650; GO:0005789; GO:0016021; GO:0007603; GO:0042574; GO:0004745 "NADP-retinol dehydrogenase activity; endoplasmic reticulum membrane; integral to membrane; phototransduction, visible light; retinal metabolic process; retinol dehydrogenase activity" IPR002198; IPR002347; IPR016040; Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) RDH11 ARSDR1 PSDR1 CGI-82 Homo sapiens (Human) TR29685_c1_g1_i1 A7Y2X0 SC6A5_XENLA 9.00E-71 GO:0016021; GO:0005328 integral to membrane; neurotransmitter:sodium symporter activity IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (xGlyT2) (Solute carrier family 6 member 5) slc6a5 glyt2 Xenopus laevis (African clawed frog) TR29685_c1_g1_i2 P23978 SC6A1_RAT 9.00E-63 GO:0030424; GO:0009986; GO:0051939; GO:0005332; GO:0005887; GO:0007612; GO:0032229; GO:0043005; GO:0005328; GO:0005886; GO:0014054; GO:0051260; GO:0051592; GO:0042220; GO:0032355; GO:0010288; GO:0014074; GO:0009744; GO:0009636 "axon; cell surface; gamma-aminobutyric acid import; gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; learning; negative regulation of synaptic transmission, GABAergic; neuron projection; neurotransmitter:sodium symporter activity; plasma membrane; positive regulation of gamma-aminobutyric acid secretion; protein homooligomerization; response to calcium ion; response to cocaine; response to estradiol stimulus; response to lead ion; response to purine-containing compound; response to sucrose stimulus; response to toxic substance" IPR000175; IPR002980; Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) Slc6a1 Gabt1 Gat-1 Gat1 Rattus norvegicus (Rat) TR2969_c0_g1_i1 P33626 TBA4_MAIZE 9.00E-18 GO:0005525; GO:0005737; GO:0005874; GO:0007017 GTP binding; cytoplasm; microtubule; microtubule-based process IPR000217; IPR003008; Tubulin alpha-4 chain (Alpha-4-tubulin) (Fragments) TUBA4 TUA4 Zea mays (Maize) TR2969_c1_g1_i1 P06603 TBA1_DROME 4.00E-61 GO:0005525; GO:0003924; GO:0019730; GO:0000235; GO:0005813; GO:0007094; GO:0007052; GO:0051258; GO:0005200 GTP binding; GTPase activity; antimicrobial humoral response; astral microtubule; centrosome; mitotic spindle assembly checkpoint; mitotic spindle organization; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-1 chain alphaTub84B tubA84B CG1913 Drosophila melanogaster (Fruit fly) TR29690_c1_g1_i1 Q0WU02 MTP10_ARATH 7.00E-55 GO:0008324; GO:0016021; GO:0005774 cation transmembrane transporter activity; integral to membrane; vacuolar membrane IPR002524; IPR027470; IPR027469; Metal tolerance protein 10 (AtMTP10) MTP10 At1g16310 F3O9.11 Arabidopsis thaliana (Mouse-ear cress) TR29691_c0_g1_i1 Q8N8K9 K1958_HUMAN 2.00E-16 IPR021893; Uncharacterized protein KIAA1958 KIAA1958 Homo sapiens (Human) TR29694_c1_g1_i1 Q04164 SAS_DROME 1.00E-07 GO:0016324; GO:0002168; GO:0005887; GO:0004872 apical plasma membrane; instar larval development; integral to plasma membrane; receptor activity IPR003961; IPR013783; IPR001007; Putative epidermal cell surface receptor (Stranded at second protein) sas CG2507 Drosophila melanogaster (Fruit fly) TR29698_c0_g1_i1 Q96MM6 HS12B_HUMAN 4.00E-22 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR29698_c1_g3_i1 O43301 HS12A_HUMAN 9.00E-38 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR29698_c1_g3_i2 Q96MM6 HS12B_HUMAN 2.00E-08 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR29700_c0_g1_i1 Q3KRF3 CA131_RAT 1.00E-08 IPR027973; Uncharacterized protein C1orf131 homolog Rattus norvegicus (Rat) TR29700_c0_g1_i2 Q8CIL4 CA131_MOUSE 3.00E-08 IPR027973; Uncharacterized protein C1orf131 homolog Mus musculus (Mouse) TR29701_c2_g1_i1 Q96NR8 RDH12_HUMAN 3.00E-88 GO:0005622; GO:0045494; GO:0060342; GO:0007603; GO:0004745; GO:0042572; GO:0007601 P0CG48 "intracellular; photoreceptor cell maintenance; photoreceptor inner segment membrane; phototransduction, visible light; retinol dehydrogenase activity; retinol metabolic process; visual perception" IPR002198; IPR002347; IPR016040; Retinol dehydrogenase 12 (EC 1.1.1.-) (All-trans and 9-cis retinol dehydrogenase) RDH12 Homo sapiens (Human) TR29702_c1_g1_i1 D2H0Y8 RN146_AILME 4.00E-52 GO:0016055; GO:0005829; GO:0005634; GO:0072572; GO:0090263; GO:0070936; GO:0051865; GO:0042787; GO:0004842; GO:0008270 Wnt receptor signaling pathway; cytosol; nucleus; poly-ADP-D-ribose binding; positive regulation of canonical Wnt receptor signaling pathway; protein K48-linked ubiquitination; protein autoubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR004170; IPR018123; IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF146 (EC 6.3.2.-) (Iduna) (RING finger protein 146) RNF146 PANDA_003130 Ailuropoda melanoleuca (Giant panda) TR29702_c1_g1_i2 D2H0Y8 RN146_AILME 4.00E-52 GO:0016055; GO:0005829; GO:0005634; GO:0072572; GO:0090263; GO:0070936; GO:0051865; GO:0042787; GO:0004842; GO:0008270 Wnt receptor signaling pathway; cytosol; nucleus; poly-ADP-D-ribose binding; positive regulation of canonical Wnt receptor signaling pathway; protein K48-linked ubiquitination; protein autoubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR004170; IPR018123; IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF146 (EC 6.3.2.-) (Iduna) (RING finger protein 146) RNF146 PANDA_003130 Ailuropoda melanoleuca (Giant panda) TR29703_c0_g1_i1 Q6Q7D1 DHI1L_BOVIN 2.00E-11 GO:0005576; GO:0016491 extracellular region; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Hydroxysteroid 11-beta-dehydrogenase 1-like protein (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type 3) (11-DH3) (11-beta-HSD3) HSD11B1L HSD3 Bos taurus (Bovine) TR29703_c0_g1_i2 Q9MYP6 DHB14_BOVIN 6.00E-71 GO:0005813; GO:0005829; GO:0004303; GO:0006706; GO:0047045 centrosome; cytosol; estradiol 17-beta-dehydrogenase activity; steroid catabolic process; testosterone 17-beta-dehydrogenase (NADP+) activity IPR002198; IPR002347; IPR016040; IPR020904; 17-beta-hydroxysteroid dehydrogenase 14 (17-beta-HSD 14) (EC 1.1.1.-) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) HSD17B14 DHRS10 SDR3 Bos taurus (Bovine) TR29705_c3_g1_i1 Q9VPW1 ASTE_DROME 3.00E-09 GO:0001752; GO:0007173; GO:0008586; GO:0007526 compound eye photoreceptor fate commitment; epidermal growth factor receptor signaling pathway; imaginal disc-derived wing vein morphogenesis; larval somatic muscle development IPR026832; Protein asteroid ast CG4426 Drosophila melanogaster (Fruit fly) TR29705_c4_g1_i1 Q1LYL8 ASTE1_DANRE 2.00E-13 IPR026832; Protein asteroid homolog 1 aste1 si:dkey-11p23.5 Danio rerio (Zebrafish) (Brachydanio rerio) TR29706_c0_g1_i2 Q6R5N8 TLR13_MOUSE 8.00E-24 GO:0002755; GO:0005768; GO:0010008; GO:0006954; GO:0045087; GO:0016021; GO:0042803; GO:0019843; GO:0043408; GO:0002237; GO:0009615; GO:0034178; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; endosome; endosome membrane; inflammatory response; innate immune response; integral to membrane; protein homodimerization activity; rRNA binding; regulation of MAPK cascade; response to molecule of bacterial origin; response to virus; toll-like receptor 13 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR003591; IPR000157; IPR027196; Toll-like receptor 13 Tlr13 Mus musculus (Mouse) TR29708_c3_g2_i1 A4IF63 TRIM2_BOVIN 3.00E-17 GO:0005737; GO:0043523; GO:0004842; GO:0008270 cytoplasm; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) TR29709_c0_g1_i1 O75575 RPC9_HUMAN 4.00E-32 GO:0009360; GO:0003899; GO:0001669; GO:0007340; GO:0001635; GO:0004948; GO:0051607; GO:0045087; GO:0007218; GO:0000166; GO:0005634; GO:0005886; GO:0006383 DNA polymerase III complex; DNA-directed RNA polymerase activity; acrosomal vesicle; acrosome reaction; calcitonin gene-related polypeptide receptor activity; calcitonin receptor activity; defense response to virus; innate immune response; neuropeptide signaling pathway; nucleotide binding; nucleus; plasma membrane; transcription from RNA polymerase III promoter IPR010997; IPR005574; IPR006590; DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17) CRCP Homo sapiens (Human) TR2971_c0_g1_i1 P16157 ANK1_HUMAN 2.00E-30 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR2971_c0_g2_i1 Q3U0D9 HACE1_MOUSE 8.00E-19 GO:0032580; GO:0000139; GO:0007030; GO:0017137; GO:0007049; GO:0005783; GO:0061025; GO:0005634; GO:0070936; GO:0042787; GO:0030334; GO:0006355; GO:0006351; GO:0004842 "Golgi cisterna membrane; Golgi membrane; Golgi organization; Rab GTPase binding; cell cycle; endoplasmic reticulum; membrane fusion; nucleus; protein K48-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of cell migration; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity" IPR002110; IPR020683; IPR000569; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HACE1 (EC 6.3.2.-) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) Hace1 Kiaa1320 Mus musculus (Mouse) TR29713_c1_g1_i1 Q63HN8 RN213_HUMAN 7.00E-30 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR018957; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) TR29714_c0_g1_i2 Q9VEB5 SRR1L_DROME 7.00E-19 GO:0007623 circadian rhythm IPR012942; SRR1-like protein CG7988 Drosophila melanogaster (Fruit fly) TR29714_c0_g1_i3 Q9UH36 SRR1L_HUMAN 4.00E-46 GO:0048511 rhythmic process IPR012942; SRR1-like protein (SRR1 domain-containing protein) SRRD SRR1L Homo sapiens (Human) TR29717_c0_g1_i1 A1XQU1 PSB7_PIG 2.00E-139 GO:0005737; GO:0005634; GO:0005839; GO:0051603; GO:0004298 cytoplasm; nucleus; proteasome core complex; proteolysis involved in cellular protein catabolic process; threonine-type endopeptidase activity IPR000243; IPR024689; IPR016050; IPR001353; IPR023333; Proteasome subunit beta type-7 (EC 3.4.25.1) PSMB7 Sus scrofa (Pig) TR29718_c2_g1_i1 Q5ND28 SREC_MOUSE 3.00E-07 GO:0007155; GO:0016358; GO:0016021; GO:0030169; GO:0016322; GO:0005886; GO:0048680; GO:0005044 cell adhesion; dendrite development; integral to membrane; low-density lipoprotein particle binding; neuron remodeling; plasma membrane; positive regulation of axon regeneration; scavenger receptor activity IPR000742; IPR013032; IPR002049; IPR009030; Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) TR29718_c2_g1_i2 Q14162 SREC_HUMAN 7.00E-07 GO:0007155; GO:0006707; GO:0016358; GO:0030666; GO:0016021; GO:0030169; GO:0016322; GO:0005886; GO:0048680; GO:0005044; GO:0004888 cell adhesion; cholesterol catabolic process; dendrite development; endocytic vesicle membrane; integral to membrane; low-density lipoprotein particle binding; neuron remodeling; plasma membrane; positive regulation of axon regeneration; scavenger receptor activity; transmembrane signaling receptor activity IPR000742; IPR013032; IPR002049; IPR009030; Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) TR29718_c4_g2_i1 P59222 SREC2_MOUSE 2.00E-07 GO:0007157; GO:0016021; GO:0005044 heterophilic cell-cell adhesion; integral to membrane; scavenger receptor activity IPR000742; IPR013032; IPR009030; Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) TR29718_c8_g1_i1 Q99M80 PTPRT_MOUSE 2.00E-83 GO:0051393; GO:0045294; GO:0008013; GO:0009986; GO:0007156; GO:0016021; GO:0005886; GO:0004725; GO:0016790; GO:0007169 alpha-actinin binding; alpha-catenin binding; beta-catenin binding; cell surface; homophilic cell adhesion; integral to membrane; plasma membrane; protein tyrosine phosphatase activity; thiolester hydrolase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) TR29720_c0_g1_i2 O00602 FCN1_HUMAN 2.00E-40 GO:0003823; GO:0005509; GO:0030246; GO:0005581; GO:0001867; GO:0005576; GO:0008228 Q2TS39 "antigen binding; calcium ion binding; carbohydrate binding; collagen; complement activation, lectin pathway; extracellular region; opsonization" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) FCN1 FCNM Homo sapiens (Human) TR29720_c0_g2_i3 P85031 TLLP_PHONI 2.00E-18 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Techylectin-like protein (Fragments) Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer) TR29720_c0_g2_i7 Q86XS5 ANGL5_HUMAN 1.00E-09 GO:0005576 extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-related protein 5 (Angiopoietin-like protein 5) ANGPTL5 UNQ5795/PRO19600 Homo sapiens (Human) TR29722_c1_g1_i1 Q568D2 CO026_DANRE 5.00E-34 Uncharacterized protein C15orf26 homolog zgc:110373 Danio rerio (Zebrafish) (Brachydanio rerio) TR29723_c0_g3_i1 Q9VR91 HERC2_DROME 4.00E-07 GO:0005814; GO:0005737; GO:0020037; GO:0046872; GO:0005634; GO:0042787; GO:0004842 centriole; cytoplasm; heme binding; metal ion binding; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR004939; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR009060; IPR015940; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) HERC2 CG11734 Drosophila melanogaster (Fruit fly) TR29724_c0_g1_i1 Q05120 UBIL_NPVOP 4.00E-39 IPR019956; IPR019954; IPR000626; Ubiquitin-like protein V-UBI ORF25 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) TR29724_c0_g1_i2 P59271 R27AA_ARATH 2.00E-45 GO:0005794; GO:0022627; GO:0046872; GO:0005634; GO:0005886; GO:0009506; GO:0003735; GO:0006412 Golgi apparatus; cytosolic small ribosomal subunit; metal ion binding; nucleus; plasma membrane; plasmodesma; structural constituent of ribosome; translation IPR002906; IPR011332; IPR019956; IPR019954; IPR000626; Ubiquitin-40S ribosomal protein S27a-1 [Cleaved into: Ubiquitin; 40S ribosomal protein S27a-1] RPS27AA UBQ16 At1g23410 F26F24.28 F28C11.5 Arabidopsis thaliana (Mouse-ear cress) TR29724_c0_g2_i1 P0CG53 UBB_BOVIN 2.00E-162 GO:0005737; GO:0005634 O14964; P38753; Q92783; P40343 cytoplasm; nucleus IPR019956; IPR019954; IPR000626; Polyubiquitin-B [Cleaved into: Ubiquitin] UBB Bos taurus (Bovine) TR29724_c0_g2_i11 D3Z3C6 ZFAN4_MOUSE 8.00E-15 GO:0008270 zinc ion binding IPR019956; IPR000626; IPR000058; AN1-type zinc finger protein 4 (AN1-type zinc finger and ubiquitin domain-containing protein-like 1) Zfand4 Anubl1 Mus musculus (Mouse) TR29724_c0_g2_i12 P23398 UBIQP_STRPU 8.00E-89 GO:0005737; GO:0005634 cytoplasm; nucleus IPR019956; IPR019954; IPR000626; Polyubiquitin [Cleaved into: Ubiquitin] (Fragment) Strongylocentrotus purpuratus (Purple sea urchin) TR29724_c0_g2_i13 P18101 RL40_DROME 7.00E-48 GO:0006464; GO:0022625; GO:0005875; GO:0005634; GO:0003735; GO:0006412; GO:0006511 cellular protein modification process; cytosolic large ribosomal subunit; microtubule associated complex; nucleus; structural constituent of ribosome; translation; ubiquitin-dependent protein catabolic process IPR001975; IPR019956; IPR019954; IPR000626; Ubiquitin-60S ribosomal protein L40 (CEP52) [Cleaved into: Ubiquitin; 60S ribosomal protein L40] RpL40 Ubi-f UBI-F52 CG2960 Drosophila melanogaster (Fruit fly) TR29724_c0_g2_i4 P0C276 RL40_SHEEP 2.00E-48 GO:0005634; GO:0005840; GO:0003735; GO:0006412 nucleus; ribosome; structural constituent of ribosome; translation IPR001975; IPR019956; IPR019954; IPR000626; Ubiquitin-60S ribosomal protein L40 (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; 60S ribosomal protein L40 (CEP52)] UBA52 UBCEP2 Ovis aries (Sheep) TR29724_c0_g2_i5 P0CG60 UBB_PONPY 5.00E-150 GO:0005737; GO:0005634 cytoplasm; nucleus IPR019956; IPR019954; IPR000626; Polyubiquitin-B [Cleaved into: Ubiquitin] UBB Pongo pygmaeus (Bornean orangutan) TR29728_c0_g1_i1 O22212 PRP4L_ARATH 6.00E-07 GO:0001709; GO:0007267; GO:0009560; GO:0000398; GO:0016607; GO:0005681 "cell fate determination; cell-cell signaling; embryo sac egg cell differentiation; mRNA splicing, via spliceosome; nuclear speck; spliceosomal complex" IPR020472; IPR027106; IPR014906; IPR003648; IPR015943; IPR001680; IPR019775; IPR017986; U4/U6 small nuclear ribonucleoprotein PRP4-like protein (Protein EMBRYO DEFECTIVE 2776) EMB2776 At2g41500 T26J13.9 T32G6.2 Arabidopsis thaliana (Mouse-ear cress) TR29728_c0_g1_i2 Q5XJP1 TSSC1_DANRE 0 IPR015943; IPR001680; IPR019775; IPR017986; Protein TSSC1 tssc1 zgc:101720 Danio rerio (Zebrafish) (Brachydanio rerio) TR29733_c0_g1_i1 Q8NCT1 ARRD4_HUMAN 1.00E-13 GO:0005768; GO:0005886; GO:0051443 endosome; plasma membrane; positive regulation of ubiquitin-protein ligase activity IPR011021; IPR011022; IPR014756; Arrestin domain-containing protein 4 ARRDC4 Homo sapiens (Human) TR29734_c1_g1_i1 Q8JI28 TLL1_XENLA 8.00E-10 GO:0005509; GO:0030154; GO:0005576; GO:0004222; GO:0007275; GO:0006508; GO:0008270 Q91713 calcium ion binding; cell differentiation; extracellular region; metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Tolloid-like protein 1 (EC 3.4.24.-) (Metalloprotease xolloid-like) (Xenopus tolloid-like protein 1) (Xlr) tll1 xlr Xenopus laevis (African clawed frog) TR29735_c0_g1_i1 Q9VCA2 ORCT_DROME 3.00E-127 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR29735_c0_g1_i2 Q9VCA2 ORCT_DROME 3.00E-120 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR29736_c1_g2_i1 Q27955 KCAB2_BOVIN 2.00E-26 GO:0005737; GO:0016021; GO:0044224; GO:0005249 cytoplasm; integral to membrane; juxtaparanode region of axon; voltage-gated potassium channel activity IPR001395; IPR005983; IPR005399; IPR005401; IPR023210; Voltage-gated potassium channel subunit beta-2 (K(+) channel subunit beta-2) (Kv-beta-2) KCNAB2 KVB2 Bos taurus (Bovine) TR29739_c0_g1_i1 Q8BXX2 ZBT49_MOUSE 6.00E-22 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) Zbtb49 Zfp509 Znf509 Mus musculus (Mouse) TR29739_c1_g1_i2 Q96MU6 ZN778_HUMAN 1.00E-17 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 778 ZNF778 Homo sapiens (Human) TR29739_c2_g1_i1 Q08875 SUHW_DROAN 8.00E-15 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Protein suppressor of hairy wing su(Hw) Drosophila ananassae (Fruit fly) TR29739_c2_g1_i2 Q8BXX2 ZBT49_MOUSE 4.00E-15 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) Zbtb49 Zfp509 Znf509 Mus musculus (Mouse) TR2974_c0_g1_i1 C4YDI6 CDC42_CANAW 1.00E-26 GO:0005525; GO:0007049; GO:0051301; GO:0005622; GO:0009405; GO:0005886; GO:0007264 GTP binding; cell cycle; cell division; intracellular; pathogenesis; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Cell division control protein 42 homolog CDC42 CAWG_00581 Candida albicans (strain WO-1) (Yeast) TR29741_c0_g1_i1 P46436 GST1_ASCSU 4.00E-42 GO:0004364 glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase 1 (EC 2.5.1.18) (GST class-sigma) GST1 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) TR29742_c0_g1_i1 O00308 WWP2_HUMAN 4.00E-11 GO:0001085; GO:0005737; GO:0019048; GO:0051224; GO:0043433; GO:0000122; GO:0032410; GO:0005634; GO:0043161; GO:0070534; GO:0042787; GO:0042391; GO:1901016; GO:0000151; GO:0004842; GO:0046718 P78563; Q01860; Q15796; P84022; O15105 RNA polymerase II transcription factor binding; cytoplasm; modulation by virus of host morphology or physiology; negative regulation of protein transport; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transporter activity; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein K63-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of membrane potential; regulation of potassium ion transmembrane transporter activity; ubiquitin ligase complex; ubiquitin-protein ligase activity; viral entry into host cell IPR000008; IPR024928; IPR000569; IPR001202; Protein modification; protein ubiquitination. NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (Atrophin-1-interacting protein 2) (AIP2) (WW domain-containing protein 2) WWP2 Homo sapiens (Human) TR29742_c0_g1_i2 Q5F389 WWOX_CHICK 3.00E-47 GO:0016055; GO:0006915; GO:0005737; GO:0005634; GO:0016491 Wnt receptor signaling pathway; apoptotic process; cytoplasm; nucleus; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR001202; WW domain-containing oxidoreductase (EC 1.1.1.-) WWOX RCJMB04_28b1 Gallus gallus (Chicken) TR29742_c1_g2_i1 Q9VLU5 WWOX_DROME 5.00E-37 GO:0016055; GO:0006915; GO:0005737; GO:0050829; GO:0016491; GO:2000377; GO:0010212 Wnt receptor signaling pathway; apoptotic process; cytoplasm; defense response to Gram-negative bacterium; oxidoreductase activity; regulation of reactive oxygen species metabolic process; response to ionizing radiation IPR002198; IPR002347; IPR016040; IPR001202; WW domain-containing oxidoreductase (EC 1.1.1.-) Wwox CG7221 Drosophila melanogaster (Fruit fly) TR29745_c1_g1_i1 Q6V0K7 OIT3_RAT 7.00E-13 GO:0005635 nuclear envelope IPR000742; IPR001507; Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein) Oit3 Lzp Rattus norvegicus (Rat) TR29745_c1_g1_i2 Q6DFV8 VWDE_MOUSE 8.00E-13 GO:0005576 extracellular region IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) TR29745_c1_g1_i3 P48733 UROM_BOVIN 8.00E-15 GO:0031225; GO:0016324; GO:0016323; GO:0005509; GO:0060170; GO:0005576; GO:0072372; GO:0000922 anchored to membrane; apical plasma membrane; basolateral plasma membrane; calcium ion binding; cilium membrane; extracellular region; primary cilium; spindle pole IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR023413; IPR009030; IPR001507; IPR017977; "Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]" UMOD Bos taurus (Bovine) TR29745_c2_g2_i3 Q862Z3 UROM_CANFA 1.00E-13 GO:0031225; GO:0016324; GO:0016323; GO:0005509; GO:0060170; GO:0005576; GO:0072372; GO:0000922 anchored to membrane; apical plasma membrane; basolateral plasma membrane; calcium ion binding; cilium membrane; extracellular region; primary cilium; spindle pole IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR023413; IPR009030; IPR001507; IPR017977; "Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]" UMOD Canis familiaris (Dog) (Canis lupus familiaris) TR29745_c2_g2_i4 Q29RU2 OIT3_BOVIN 5.00E-12 GO:0005509; GO:0005635 calcium ion binding; nuclear envelope IPR000742; IPR000152; IPR018097; IPR009030; IPR001507; Oncoprotein-induced transcript 3 protein OIT3 Bos taurus (Bovine) TR29746_c0_g1_i1 Q3E956 NAT9_ARATH 8.00E-09 GO:0016021; GO:0055085; GO:0005215 integral to membrane; transmembrane transport; transporter activity IPR006043; Putative nucleobase-ascorbate transporter 9 (AtNAT9) NAT9 At5g25420 F18G18.160 Arabidopsis thaliana (Mouse-ear cress) TR29746_c0_g2_i1 B0JZG0 S23A2_XENTR 2.00E-117 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR006042; IPR006043; Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR29750_c0_g1_i1 Q99NI4 IPMK_RAT 8.00E-52 GO:0005524; GO:0032958; GO:0000824; GO:0008440; GO:0000823; GO:0001841; GO:0005634 "ATP binding; inositol phosphate biosynthetic process; inositol tetrakisphosphate 3-kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; inositol-1,4,5-trisphosphate 6-kinase activity; neural tube formation; nucleus" IPR005522; "Inositol polyphosphate multikinase (EC 2.7.1.151) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase)" Ipmk Impk Rattus norvegicus (Rat) TR29750_c0_g1_i3 Q96PC2 IP6K3_HUMAN 3.00E-19 GO:0005524; GO:0005829; GO:0052723; GO:0052724; GO:0000832; GO:0000831; GO:0032958; GO:0008440; GO:0005634; GO:0046488; GO:0006468 "ATP binding; cytosol; inositol hexakisphosphate 1-kinase activity; inositol hexakisphosphate 3-kinase activity; inositol hexakisphosphate 5-kinase activity; inositol hexakisphosphate 6-kinase activity; inositol phosphate biosynthetic process; inositol-1,4,5-trisphosphate 3-kinase activity; nucleus; phosphatidylinositol metabolic process; protein phosphorylation" IPR005522; Inositol hexakisphosphate kinase 3 (InsP6 kinase 3) (EC 2.7.4.21) (Inositol hexaphosphate kinase 3) IP6K3 IHPK3 Homo sapiens (Human) TR29752_c0_g2_i1 Q61361 PGCB_MOUSE 6.00E-06 GO:0030246; GO:0007155; GO:0021766; GO:0005540; GO:0005578 carbohydrate binding; cell adhesion; hippocampus development; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR007110; IPR013783; IPR003006; IPR013106; IPR003596; IPR000538; IPR000436; Brevican core protein Bcan Mus musculus (Mouse) TR29753_c3_g1_i1 Q40517 NTF3_TOBAC 1.00E-07 GO:0005524; GO:0004707; GO:0000165 ATP binding; MAP kinase activity; MAPK cascade IPR011009; IPR003527; IPR000719; IPR017441; IPR002290; IPR008271; Mitogen-activated protein kinase homolog NTF3 (EC 2.7.11.24) (P43) NTF3 Nicotiana tabacum (Common tobacco) TR29753_c3_g1_i3 Q14012 KCC1A_HUMAN 2.00E-07 GO:0005524; GO:0004683; GO:0007049; GO:0005737; GO:0006913; GO:0005634; GO:0060999; GO:0051149; GO:0010976; GO:0046827; GO:0071902; GO:0051835; GO:0043393; GO:0032880; GO:0007165 ATP binding; calmodulin-dependent protein kinase activity; cell cycle; cytoplasm; nucleocytoplasmic transport; nucleus; positive regulation of dendritic spine development; positive regulation of muscle cell differentiation; positive regulation of neuron projection development; positive regulation of protein export from nucleus; positive regulation of protein serine/threonine kinase activity; positive regulation of synapse structural plasticity; regulation of protein binding; regulation of protein localization; signal transduction IPR020636; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) CAMK1 Homo sapiens (Human) TR29753_c3_g2_i1 P28583 CDPK_SOYBN 1.00E-07 GO:0005524; GO:0005509; GO:0004674 ATP binding; calcium ion binding; protein serine/threonine kinase activity IPR011992; IPR018247; IPR002048; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium-dependent protein kinase SK5 (CDPK) (EC 2.7.11.1) Glycine max (Soybean) (Glycine hispida) TR29753_c4_g1_i1 O00311 CDC7_HUMAN 2.00E-58 GO:0005524; GO:0006260; GO:0000082; GO:0051301; GO:0005737; GO:0016301; GO:0046872; GO:0005654; GO:0008284; GO:0004674 ATP binding; DNA replication; G1/S transition of mitotic cell cycle; cell division; cytoplasm; kinase activity; metal ion binding; nucleoplasm; positive regulation of cell proliferation; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) CDC7 CDC7L1 Homo sapiens (Human) TR29754_c0_g1_i1 Q9VE11 U488_DROME 1.00E-15 UPF0488 protein CG14286 CG14286 Drosophila melanogaster (Fruit fly) TR29754_c0_g1_i2 Q5BJC4 CH033_DANRE 2.00E-19 UPF0488 protein C8orf33 homolog zgc:112185 Danio rerio (Zebrafish) (Brachydanio rerio) TR29756_c0_g2_i1 Q8BHN5 RBM45_MOUSE 1.00E-44 GO:0003723; GO:0030154; GO:0005737; GO:0007399; GO:0000166; GO:0005634 RNA binding; cell differentiation; cytoplasm; nervous system development; nucleotide binding; nucleus IPR012677; IPR000504; RNA-binding protein 45 (Developmentally-regulated RNA-binding protein 1) (RB-1) (RNA-binding motif protein 45) Rbm45 Drb1 Drbp1 Mus musculus (Mouse) TR29756_c0_g2_i3 Q8BHN5 RBM45_MOUSE 3.00E-44 GO:0003723; GO:0030154; GO:0005737; GO:0007399; GO:0000166; GO:0005634 RNA binding; cell differentiation; cytoplasm; nervous system development; nucleotide binding; nucleus IPR012677; IPR000504; RNA-binding protein 45 (Developmentally-regulated RNA-binding protein 1) (RB-1) (RNA-binding motif protein 45) Rbm45 Drb1 Drbp1 Mus musculus (Mouse) TR29757_c0_g1_i1 Q68CZ1 FTM_HUMAN 1.00E-54 GO:0043010; GO:0005911; GO:0005813; GO:0021549; GO:0042384; GO:0035085; GO:0022038; GO:0007368; GO:0035115; GO:0035116; GO:0007163; GO:0060322; GO:0001701; GO:0001822; GO:0021670; GO:0001889; GO:0005932; GO:0045744; GO:0021532; GO:0043584; GO:0021772; GO:0060039; GO:0008589; GO:0005923 camera-type eye development; cell-cell junction; centrosome; cerebellum development; cilium assembly; cilium axoneme; corpus callosum development; determination of left/right symmetry; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; establishment or maintenance of cell polarity; head development; in utero embryonic development; kidney development; lateral ventricle development; liver development; microtubule basal body; negative regulation of G-protein coupled receptor protein signaling pathway; neural tube patterning; nose development; olfactory bulb development; pericardium development; regulation of smoothened signaling pathway; tight junction IPR000008; IPR021656; Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein) RPGRIP1L FTM KIAA1005 NPHP8 Homo sapiens (Human) TR29757_c1_g1_i1 Q96KN7 RPGR1_HUMAN 6.00E-23 GO:0005930; GO:0005929; GO:0042462; GO:0050896; GO:0060041; GO:0007601 axoneme; cilium; eye photoreceptor cell development; response to stimulus; retina development in camera-type eye; visual perception IPR000008; IPR021656; X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1) RPGRIP1 Homo sapiens (Human) TR29758_c0_g1_i1 P05932 CALMB_ARBPU 9.00E-45 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-beta (Cam B) (Fragment) Arbacia punctulata (Punctuate sea urchin) TR29758_c0_g1_i2 Q95NI4 CALM_HALOK 1.00E-45 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Halichondria okadai (Marine sponge) (Reniera okadai) TR29762_c1_g1_i1 Q5ZKJ5 TM180_CHICK 1.00E-29 GO:0016021 integral to membrane IPR016196; Transmembrane protein 180 TMEM180 RCJMB04_10g6 Gallus gallus (Chicken) TR29768_c0_g2_i2 Q8MU52 GST_PLAFA 4.00E-20 GO:0004364 glutathione transferase activity IPR010987; IPR004045; IPR012336; Glutathione S-transferase (EC 2.5.1.18) (PfGST) GST Plasmodium falciparum TR29774_c1_g1_i1 Q9D5U8 CT152_MOUSE 6.00E-12 IPR018490; IPR018488; IPR000595; IPR014710; Cyclic nucleotide-binding domain-containing protein 2 Cnbd2 Mus musculus (Mouse) TR29775_c1_g1_i1 Q9D845 TEX9_MOUSE 6.00E-81 Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1) Tex9 Mus musculus (Mouse) TR29776_c0_g1_i1 Q9QZC2 PLXC1_MOUSE 2.00E-34 GO:0016021; GO:0005622; GO:0007275; GO:0004872; GO:0007165 integral to membrane; intracellular; multicellular organismal development; receptor activity; signal transduction IPR013783; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-C1 (Virus-encoded semaphorin protein receptor) (CD antigen CD232) Plxnc1 Vespr Mus musculus (Mouse) TR29776_c0_g1_i2 Q6BEA0 PLXA4_DANRE 4.00E-45 GO:0007411; GO:0007414; GO:0016021; GO:0005622; GO:0001763; GO:0005886; GO:0004872; GO:0007165 axon guidance; axonal defasciculation; integral to membrane; intracellular; morphogenesis of a branching structure; plasma membrane; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A4 plxna4 Danio rerio (Zebrafish) (Brachydanio rerio) TR29781_c0_g1_i1 Q7TNM2 TRI46_MOUSE 7.00E-07 GO:0005622; GO:0008270 intracellular; zinc ion binding IPR001870; IPR008985; IPR017903; IPR003961; IPR013783; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; "Tripartite motif-containing protein 46 (Gene Y protein) (GeneY) (Tripartite, fibronectin type-III and C-terminal SPRY motif protein)" Trim46 Trific Mus musculus (Mouse) TR29781_c0_g1_i2 Q9UPN9 TRI33_HUMAN 6.00E-13 GO:0003677; GO:0030514; GO:0000122; GO:0005654; GO:0017015; GO:0006367; GO:0007179; GO:0004842; GO:0008270 Q15796; Q13485 DNA binding; negative regulation of BMP signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; regulation of transforming growth factor beta receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) TRIM33 KIAA1113 RFG7 TIF1G Homo sapiens (Human) TR29783_c0_g1_i1 Q5RF33 DSCR3_PONAB 4.00E-64 GO:0005634; GO:0030904; GO:0007034 nucleus; retromer complex; vacuolar transport IPR014756; IPR005377; Down syndrome critical region protein 3 homolog DSCR3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR29783_c0_g2_i1 O35075 DSCR3_MOUSE 6.00E-69 GO:0005634; GO:0030904; GO:0007034 nucleus; retromer complex; vacuolar transport IPR014756; IPR005377; Down syndrome critical region protein 3 homolog (Down syndrome critical region protein A homolog) Dscr3 Dcra Dscra Mus musculus (Mouse) TR29785_c5_g1_i1 Q9DBQ9 SWT1_MOUSE 1.00E-06 IPR002716; Transcriptional protein SWT1 Swt1 Mus musculus (Mouse) TR29785_c6_g1_i1 Q68FN9 FAKD3_RAT 4.00E-11 GO:0045333; GO:0005739; GO:0004672; GO:0006468 cellular respiration; mitochondrion; protein kinase activity; protein phosphorylation IPR013579; IPR010622; IPR013584; FAST kinase domain-containing protein 3 Fastkd3 Rattus norvegicus (Rat) TR29786_c0_g1_i1 A1USL0 RS7_BARBK 5.00E-29 GO:0019843; GO:0015935; GO:0003735; GO:0000049; GO:0006412 rRNA binding; small ribosomal subunit; structural constituent of ribosome; tRNA binding; translation IPR000235; IPR005717; IPR020606; IPR023798; 30S ribosomal protein S7 rpsG1 BARBAKC583_0662; rpsG2 BARBAKC583_0694 Bartonella bacilliformis (strain ATCC 35685 / KC583) TR29786_c0_g1_i2 Q5ZMU0 RT07_CHICK 1.00E-50 GO:0003723; GO:0022627; GO:0005739; GO:0003735; GO:0006412 RNA binding; cytosolic small ribosomal subunit; mitochondrion; structural constituent of ribosome; translation IPR000235; IPR023798; "28S ribosomal protein S7, mitochondrial (MRP-S7) (S7mt)" MRPS7 RCJMB04_1c20 Gallus gallus (Chicken) TR29787_c2_g1_i1 Q9NWZ3 IRAK4_HUMAN 3.00E-37 GO:0005524; GO:0007254; GO:0002755; GO:0001816; GO:0019221; GO:0005829; GO:0010008; GO:0045087; GO:0000287; GO:0005886; GO:0048661; GO:0045944; GO:0004674; GO:0034166; GO:0034134; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124 Q9HAT8; P58753 ATP binding; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; cytokine production; cytokine-mediated signaling pathway; cytosol; endosome membrane; innate immune response; magnesium ion binding; plasma membrane; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; protein serine/threonine kinase activity; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor TLR1:TLR2 signaling pathway; toll-like receptor TLR6:TLR2 signaling pathway IPR011029; IPR017428; IPR011009; IPR000719; Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) IRAK4 Homo sapiens (Human) TR29788_c0_g1_i1 Q8IXM7 OD3L1_HUMAN 2.00E-37 IPR010736; Outer dense fiber protein 3-like protein 1 ODF3L1 Homo sapiens (Human) TR29788_c0_g1_i2 A3KQA5 ODF3B_DANRE 4.00E-77 GO:0005737 cytoplasm IPR010736; Outer dense fiber protein 3-B (Outer dense fiber of sperm tails protein 3-B) (Outer dense fiber protein 3-like) odf3b odf3 odf3l si:dkey-238c7.9 si:dkeyp-1h4.4 zgc:63985 Danio rerio (Zebrafish) (Brachydanio rerio) TR29792_c1_g1_i1 Q8BUV3 GEPH_MOUSE 2.00E-46 GO:0005524; GO:0006777; GO:0030054; GO:0005737; GO:0008092; GO:0005856; GO:0007529; GO:0019897; GO:0005622; GO:0046872; GO:0045211; GO:0016740 P48168; Q9QUR7 ATP binding; Mo-molybdopterin cofactor biosynthetic process; cell junction; cytoplasm; cytoskeletal protein binding; cytoskeleton; establishment of synaptic specificity at neuromuscular junction; extrinsic to plasma membrane; intracellular; metal ion binding; postsynaptic membrane; transferase activity IPR020817; IPR008284; IPR005111; IPR005110; IPR001453; Cofactor biosynthesis; molybdopterin biosynthesis. Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)] Gphn Mus musculus (Mouse) TR29792_c1_g1_i2 Q8U3T3 MOAB_PYRFU 2.00E-10 GO:0005524; GO:0006777; GO:0016740 ATP binding; Mo-molybdopterin cofactor biosynthetic process; transferase activity IPR020817; IPR012245; IPR008284; IPR001453; Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) moaB PF0372 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) TR29792_c1_g1_i3 Q9NQX3 GEPH_HUMAN 2.00E-154 GO:0005524; GO:0006777; GO:0030054; GO:0005737; GO:0005856; GO:0007529; GO:0046872; GO:0032324; GO:0005886; GO:0045211; GO:0016740; GO:0006767 ATP binding; Mo-molybdopterin cofactor biosynthetic process; cell junction; cytoplasm; cytoskeleton; establishment of synaptic specificity at neuromuscular junction; metal ion binding; molybdopterin cofactor biosynthetic process; plasma membrane; postsynaptic membrane; transferase activity; water-soluble vitamin metabolic process IPR020817; IPR008284; IPR005111; IPR005110; IPR001453; Cofactor biosynthesis; molybdopterin biosynthesis. Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)] GPHN GPH KIAA1385 Homo sapiens (Human) TR29792_c1_g1_i5 Q9ZL45 MOG_HELPJ 5.00E-26 GO:0005524; GO:0006777; GO:0016740 ATP binding; Mo-molybdopterin cofactor biosynthetic process; transferase activity IPR020817; IPR008284; IPR001453; Cofactor biosynthesis; molybdopterin biosynthesis. Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) mog mogA jhp_0735 Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) TR29795_c0_g1_i1 O43325 LYRM1_HUMAN 4.00E-31 GO:0005739; GO:0005634 mitochondrion; nucleus IPR008011; LYR motif-containing protein 1 LYRM1 Homo sapiens (Human) TR29795_c0_g1_i5 Q54T58 LYRM1_DICDI 5.00E-10 IPR008011; LYR motif-containing protein 1 lyrm1 DDB_G0281987 Dictyostelium discoideum (Slime mold) TR29795_c0_g2_i1 B5X5L2 LYRM1_SALSA 9.00E-06 IPR008011; LYR motif-containing protein 1 lyrm1 Salmo salar (Atlantic salmon) TR29796_c0_g2_i2 Q91ZN5 S35B2_MOUSE 8.00E-139 GO:0046964; GO:0046963; GO:0000139; GO:0016021; GO:0043123; GO:0004871 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity; 3'-phosphoadenosine 5'-phosphosulfate transport; Golgi membrane; integral to membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity IPR013657; Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPS transporter 1) (Solute carrier family 35 member B2) Slc35b2 J207 Papst1 Mus musculus (Mouse) TR29796_c0_g2_i3 Q55DM5 S35B2_DICDI 8.00E-60 GO:0000139; GO:0016021; GO:0055085 Golgi membrane; integral to membrane; transmembrane transport IPR013657; Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPS transporter 1) (Solute carrier family 35 member B2) slc35b2 papst1 DDB_G0269602 Dictyostelium discoideum (Slime mold) TR29797_c0_g1_i1 Q6NWH0 CK068_DANRE 3.00E-18 IPR015034; IPR023398; UPF0696 protein C11orf68 homolog P5436 zgc:63470 Danio rerio (Zebrafish) (Brachydanio rerio) TR29799_c3_g1_i1 Q179T2 MUT7_AEDAE 2.00E-75 GO:0008408; GO:0003676; GO:0090305 3'-5' exonuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis IPR002562; IPR012337; Probable exonuclease mut-7 homolog (EC 3.1.-.-) (Exonuclease 3'-5' domain-containing protein 3 homolog) AAEL005527 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR29800_c0_g1_i1 Q90Z12 HES4A_XENLA 1.00E-50 GO:0030509; GO:0008283; GO:0033504; GO:0002088; GO:0043066; GO:0000122; GO:0014029; GO:0005634; GO:0021501; GO:0043565; GO:0006351 "BMP signaling pathway; cell proliferation; floor plate development; lens development in camera-type eye; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter; neural crest formation; nucleus; prechordal plate formation; sequence-specific DNA binding; transcription, DNA-dependent" IPR011598; IPR003650; IPR018352; Transcription factor HES-4-A (Hairy and enhancer of split 4-A) (Protein hairy-2) (Xhairy2) (Protein hairy-2a) (Xhairy2a) hes4-a hairy2 hairy2a Xenopus laevis (African clawed frog) TR29803_c0_g1_i3 P48556 PSMD8_HUMAN 1.00E-113 GO:0006977; GO:0000082; GO:0031145; GO:0002479; GO:0006915; GO:0005829; GO:0010467; GO:0016071; GO:0043066; GO:0051436; GO:0005654; GO:0051437; GO:0005838; GO:0000209; GO:0006521; GO:0044281; GO:0016032 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G1/S transition of mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic process; cytosol; gene expression; mRNA metabolic process; negative regulation of apoptotic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; proteasome regulatory particle; protein polyubiquitination; regulation of cellular amino acid metabolic process; small molecule metabolic process; viral process" IPR006746; 26S proteasome non-ATPase regulatory subunit 8 (26S proteasome regulatory subunit RPN12) (26S proteasome regulatory subunit S14) (p31) PSMD8 Homo sapiens (Human) TR29805_c3_g2_i1 Q8WV99 ZFN2B_HUMAN 7.00E-60 GO:0005783; GO:0008270 Q15038 endoplasmic reticulum; zinc ion binding IPR003903; IPR000058; AN1-type zinc finger protein 2B (Arsenite-inducible RNA-associated protein-like protein) (AIRAP-like protein) ZFAND2B AIRAPL Homo sapiens (Human) TR29806_c0_g1_i1 Q3T100 MGST3_BOVIN 5.00E-38 GO:0005783; GO:0005789; GO:0004602; GO:0004364; GO:0016021; GO:0005635 endoplasmic reticulum; endoplasmic reticulum membrane; glutathione peroxidase activity; glutathione transferase activity; integral to membrane; nuclear envelope IPR023352; IPR001129; Microsomal glutathione S-transferase 3 (Microsomal GST-3) (EC 2.5.1.18) MGST3 Bos taurus (Bovine) TR29809_c0_g1_i1 P24733 MYS_AEQIR 2.00E-89 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR015650; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, striated muscle" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR29811_c1_g2_i1 Q5R6L8 GPI8_PONAB 7.00E-136 GO:0003923; GO:0042765; GO:0016255; GO:0004197; GO:0006508 GPI-anchor transamidase activity; GPI-anchor transamidase complex; attachment of GPI anchor to protein; cysteine-type endopeptidase activity; proteolysis IPR028361; IPR001096; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. GPI-anchor transamidase (GPI transamidase) (EC 3.-.-.-) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K) PIGK Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR29812_c2_g1_i1 Q9UKV8 AGO2_HUMAN 0 GO:0038095; GO:0007219; GO:0016442; GO:0000340; GO:0000932; GO:0005829; GO:0070551; GO:0007173; GO:0008543; GO:0045087; GO:0003729; GO:0005845; GO:0035279; GO:0046872; GO:0035068; GO:0035278; GO:0045947; GO:0048011; GO:0005634; GO:0048015; GO:0005844; GO:1900153; GO:0060213; GO:0009791; GO:0031054; GO:0006355; GO:0035197; GO:0006351; GO:0003743 Q9UIV1; Q96C10; Q9UPY3; Q13541; P63244; O15397; Q5S007; Q15633; Q9UHD2; A7MCY6; Q8NDV7; Q9UPQ9; Q9HCJ0; Q9HA38 "Fc-epsilon receptor signaling pathway; Notch signaling pathway; RISC complex; RNA 7-methylguanosine cap binding; cytoplasmic mRNA processing body; cytosol; endoribonuclease activity, cleaving siRNA-paired mRNA; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; mRNA binding; mRNA cap binding complex; mRNA cleavage involved in gene silencing by miRNA; metal ion binding; micro-ribonucleoprotein complex; negative regulation of translation involved in gene silencing by miRNA; negative regulation of translational initiation; neurotrophin TRK receptor signaling pathway; nucleus; phosphatidylinositol-mediated signaling; polysome; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; post-embryonic development; pre-miRNA processing; regulation of transcription, DNA-dependent; siRNA binding; transcription, DNA-dependent; translation initiation factor activity" IPR014811; IPR003100; IPR003165; IPR012337; Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) AGO2 EIF2C2 Homo sapiens (Human) TR29813_c0_g1_i3 Q8TEA8 DTD1_HUMAN 1.00E-63 GO:0019478; GO:0003677; GO:0006260; GO:0005737; GO:0016788; GO:0046872; GO:0005730 "D-amino acid catabolic process; DNA binding; DNA replication; cytoplasm; hydrolase activity, acting on ester bonds; metal ion binding; nucleolus" IPR023509; IPR003732; D-tyrosyl-tRNA(Tyr) deacylase 1 (EC 3.1.-.-) (DNA-unwinding element-binding protein B) (DUE-B) (Histidyl-tRNA synthase-related) DTD1 C20orf88 DUEB HARS2 Homo sapiens (Human) TR29815_c0_g1_i1 Q5VVC0 CA146_HUMAN 8.00E-14 IPR027857; Uncharacterized protein C1orf146 C1orf146 Homo sapiens (Human) TR29816_c0_g1_i1 Q26630 IDLC_STRPU 3.00E-133 GO:0030286; GO:0003774 dynein complex; motor activity IPR019347; "33 kDa inner dynein arm light chain, axonemal (p33)" Strongylocentrotus purpuratus (Purple sea urchin) TR29820_c1_g1_i1 Q8BG94 COMD7_MOUSE 2.00E-70 GO:0032088; GO:0045892; GO:0033209 "negative regulation of NF-kappaB transcription factor activity; negative regulation of transcription, DNA-dependent; tumor necrosis factor-mediated signaling pathway" IPR017920; IPR009886; COMM domain-containing protein 7 Commd7 Mus musculus (Mouse) TR29821_c1_g1_i1 Q9DBX3 SUSD2_MOUSE 7.00E-62 GO:0006955; GO:0016021; GO:0030247; GO:0005044 immune response; integral to membrane; polysaccharide binding; scavenger receptor activity IPR005533; IPR001212; IPR000436; IPR001846; Sushi domain-containing protein 2 Susd2 Mus musculus (Mouse) TR29821_c3_g1_i2 Q9UGT4 SUSD2_HUMAN 5.00E-07 GO:0006955; GO:0016021; GO:0030247; GO:0005044 immune response; integral to membrane; polysaccharide binding; scavenger receptor activity IPR005533; IPR001212; IPR000436; IPR001846; Sushi domain-containing protein 2 SUSD2 Homo sapiens (Human) TR29825_c3_g1_i1 Q5T2D3 OTUD3_HUMAN 6.00E-67 GO:0035871; GO:0044313; GO:0006508; GO:0004843 protein K11-linked deubiquitination; protein K6-linked deubiquitination; proteolysis; ubiquitin-specific protease activity IPR003323; OTU domain-containing protein 3 (EC 3.4.19.12) OTUD3 KIAA0459 Homo sapiens (Human) TR29825_c3_g1_i2 Q01804 OTUD4_HUMAN 1.00E-11 GO:0071108; GO:0006508; GO:0004843 protein K48-linked deubiquitination; proteolysis; ubiquitin-specific protease activity IPR003323; OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) OTUD4 HIN1 KIAA1046 Homo sapiens (Human) TR29826_c2_g1_i1 Q8C8H8 KY_MOUSE 4.00E-24 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) TR29826_c2_g1_i3 Q8C8H8 KY_MOUSE 5.00E-24 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) TR29829_c0_g1_i1 Q5NDE4 GTDC2_TAKRU 6.00E-47 GO:0008375; GO:0005783; GO:0005789; GO:0016021; GO:0006493 acetylglucosaminyltransferase activity; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; protein O-linked glycosylation IPR003961; IPR007657; IPR013783; Protein modification; protein glycosylation. "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2) (EC 2.4.1.-) (Extracellular O-linked N-acetylglucosamine transferase-like) (Glycosyltransferase-like domain-containing protein 2)" pomgnt2 ago61 gtdc2 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR29829_c0_g2_i1 Q5NDE8 GTDC2_CHICK 4.00E-51 GO:0008375; GO:0005783; GO:0005789; GO:0016021; GO:0006493 acetylglucosaminyltransferase activity; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; protein O-linked glycosylation IPR003961; IPR007657; IPR013783; Protein modification; protein glycosylation. "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2) (EC 2.4.1.-) (Extracellular O-linked N-acetylglucosamine transferase-like) (Glycosyltransferase-like domain-containing protein 2)" POMGNT2 AGO61 GTDC2 Gallus gallus (Chicken) TR2983_c0_g1_i2 Q0P6D2 FA69C_HUMAN 2.00E-08 GO:0005789; GO:0016021; GO:0016772 "endoplasmic reticulum membrane; integral to membrane; transferase activity, transferring phosphorus-containing groups" IPR022049; IPR011009; Protein FAM69C FAM69C C18orf51 Homo sapiens (Human) TR29830_c1_g1_i1 Q9CPU9 COPT2_MOUSE 3.00E-07 GO:0005375; GO:0016021 copper ion transmembrane transporter activity; integral to membrane IPR007274; Probable low affinity copper uptake protein 2 (Copper transporter 2) (CTR2) (Solute carrier family 31 member 2) Slc31a2 Mus musculus (Mouse) TR29830_c1_g1_i3 Q9CPU9 COPT2_MOUSE 9.00E-06 GO:0005375; GO:0016021 copper ion transmembrane transporter activity; integral to membrane IPR007274; Probable low affinity copper uptake protein 2 (Copper transporter 2) (CTR2) (Solute carrier family 31 member 2) Slc31a2 Mus musculus (Mouse) TR29830_c1_g1_i4 O15432 COPT2_HUMAN 2.00E-06 GO:0005375; GO:0005887 copper ion transmembrane transporter activity; integral to plasma membrane IPR007274; Probable low affinity copper uptake protein 2 (Copper transporter 2) (hCTR2) (Solute carrier family 31 member 2) SLC31A2 COPT2 CTR2 Homo sapiens (Human) TR29831_c0_g1_i1 Q9CPW4 ARPC5_MOUSE 1.00E-48 GO:0005885; GO:0005737; GO:0030027; GO:0030833 Arp2/3 protein complex; cytoplasm; lamellipodium; regulation of actin filament polymerization IPR006789; Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC) Arpc5 Mus musculus (Mouse) TR29832_c2_g1_i1 Q5RBN8 LIN54_PONAB 1.00E-108 GO:0003677; GO:0007049; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cell cycle; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR005172; IPR028307; Protein lin-54 homolog LIN54 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR29833_c1_g1_i1 Q6P2C0 WDR93_HUMAN 1.00E-14 GO:0022900; GO:0016651 "electron transport chain; oxidoreductase activity, acting on NAD(P)H" IPR006885; IPR015943; IPR017986; WD repeat-containing protein 93 WDR93 Homo sapiens (Human) TR29833_c1_g2_i1 Q402B2 WDR93_MOUSE 6.00E-11 GO:0022900; GO:0016651 "electron transport chain; oxidoreductase activity, acting on NAD(P)H" IPR006885; IPR015943; IPR017986; WD repeat-containing protein 93 (Protein MA0035) Wdr93 Mus musculus (Mouse) TR29835_c0_g1_i1 Q6PKH6 DR4L2_HUMAN 1.00E-20 GO:0005576; GO:0016491 extracellular region; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Dehydrogenase/reductase SDR family member 4-like 2 (EC 1.1.-.-) DHRS4L2 Homo sapiens (Human) TR29835_c0_g1_i2 Q920P0 DCXR_RAT 4.00E-35 GO:0042732; GO:0050038; GO:0006739; GO:0005903; GO:0005881; GO:0006006; GO:0016020; GO:0005902; GO:0016655; GO:0051289; GO:0005997 "D-xylose metabolic process; L-xylulose reductase (NADP+) activity; NADP metabolic process; brush border; cytoplasmic microtubule; glucose metabolic process; membrane; microvillus; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; protein homotetramerization; xylulose metabolic process" IPR002198; IPR002347; IPR016040; IPR020904; L-xylulose reductase (XR) (EC 1.1.1.10) (Dicarbonyl/L-xylulose reductase) Dcxr Glb Rattus norvegicus (Rat) TR29838_c0_g1_i1 P46635 THTR_CRIGR 5.00E-55 GO:0008097; GO:0005759; GO:0035928; GO:0004792 5S rRNA binding; mitochondrial matrix; rRNA import into mitochondrion; thiosulfate sulfurtransferase activity IPR001763; IPR001307; Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese) TST Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR29839_c3_g1_i1 P21359 NF1_HUMAN 9.00E-133 GO:0000165; GO:0005099; GO:0007265; GO:0030036; GO:0030325; GO:0048844; GO:0030424; GO:0048593; GO:0021987; GO:0030199; GO:0005737; GO:0030425; GO:0021897; GO:0048853; GO:0007507; GO:0031235; GO:0001889; GO:0001656; GO:0022011; GO:0043407; GO:0035021; GO:0046580; GO:0016525; GO:0048712; GO:0030336; GO:0001953; GO:0001937; GO:0048147; GO:0007406; GO:0046929; GO:0048715; GO:0045671; GO:0042992; GO:0021915; GO:0005634; GO:0001649; GO:0014065; GO:0043473; GO:0045762; GO:0001938; GO:0043525; GO:0045765; GO:0043535; GO:0045124; GO:0001952; GO:0048169; GO:0032228; GO:0001666; GO:0007519; GO:0048745; GO:0021510; GO:0048485; GO:0008542; GO:0042060 P05067; P34741 "MAPK cascade; Ras GTPase activator activity; Ras protein signal transduction; actin cytoskeleton organization; adrenal gland development; artery morphogenesis; axon; camera-type eye morphogenesis; cerebral cortex development; collagen fibril organization; cytoplasm; dendrite; forebrain astrocyte development; forebrain morphogenesis; heart development; intrinsic to internal side of plasma membrane; liver development; metanephros development; myelination in peripheral nervous system; negative regulation of MAP kinase activity; negative regulation of Rac protein signal transduction; negative regulation of Ras protein signal transduction; negative regulation of angiogenesis; negative regulation of astrocyte differentiation; negative regulation of cell migration; negative regulation of cell-matrix adhesion; negative regulation of endothelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of neuroblast proliferation; negative regulation of neurotransmitter secretion; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of transcription factor import into nucleus; neural tube development; nucleus; osteoblast differentiation; phosphatidylinositol 3-kinase cascade; pigmentation; positive regulation of adenylate cyclase activity; positive regulation of endothelial cell proliferation; positive regulation of neuron apoptotic process; regulation of angiogenesis; regulation of blood vessel endothelial cell migration; regulation of bone resorption; regulation of cell-matrix adhesion; regulation of long-term neuronal synaptic plasticity; regulation of synaptic transmission, GABAergic; response to hypoxia; skeletal muscle tissue development; smooth muscle tissue development; spinal cord development; sympathetic nervous system development; visual learning; wound healing" IPR011989; IPR016024; IPR001251; IPR001936; IPR023152; IPR008936; Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] NF1 Homo sapiens (Human) TR29840_c1_g2_i2 Q9TTC7 FUT2_HYLLA 5.00E-32 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2)" FUT2 Hylobates lar (Common gibbon) (White-handed gibbon) TR29841_c4_g1_i1 Q5BKL8 XIAP_XENTR 5.00E-08 GO:0016055; GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0045861; GO:0008270 Wnt receptor signaling pathway; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; negative regulation of proteolysis; zinc ion binding IPR001370; IPR001841; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (X-linked inhibitor of apoptosis protein) (X-linked IAP) xiap birc4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR29841_c4_g1_i2 Q96P09 BIRC8_HUMAN 6.00E-11 GO:0005829; GO:0043154; GO:0043524; GO:0005634; GO:0048471; GO:0043234; GO:0008270 cytosol; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of neuron apoptotic process; nucleus; perinuclear region of cytoplasm; protein complex; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis-like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis) BIRC8 ILP2 Homo sapiens (Human) TR29841_c4_g1_i4 Q62210 BIRC2_MOUSE 7.00E-12 GO:0035631; GO:0006915; GO:0005737; GO:0009898; GO:0070266; GO:0060546; GO:1902443; GO:0005634; GO:0001890; GO:0043123; GO:0043161; GO:0070936; GO:0070534; GO:0042981; GO:0051726; GO:2000377; GO:0006355; GO:0003713; GO:0006351; GO:0004842; GO:0008270 "CD40 receptor complex; apoptotic process; cytoplasm; internal side of plasma membrane; necroptosis; negative regulation of necroptosis; negative regulation of ripoptosome assembly involved in necroptosis; nucleus; placenta development; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; protein K63-linked ubiquitination; regulation of apoptotic process; regulation of cell cycle; regulation of reactive oxygen species metabolic process; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (Inhibitor of apoptosis protein 2) (IAP-2) (mIAP-2) (mIAP2) Birc2 Birc3 Iap2 Mus musculus (Mouse) TR29841_c4_g1_i5 Q90660 BIR_CHICK 9.00E-13 GO:0006915; GO:0005737; GO:0043066; GO:0005634; GO:0008270 apoptotic process; cytoplasm; negative regulation of apoptotic process; nucleus; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Inhibitor of apoptosis protein (IAP) (Inhibitor of T-cell apoptosis protein) ITA IAP1 Gallus gallus (Chicken) TR29843_c0_g2_i1 Q9P2D7 DYH1_HUMAN 1.00E-71 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018; GO:0009612 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement; response to mechanical stimulus IPR011704; IPR026983; IPR026975; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 1, axonemal (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1) (Heat shock regulated protein 1) (HSRF-1) (hDHC7)" DNAH1 DHC7 DNAHC1 KIAA1410 Homo sapiens (Human) TR29843_c0_g2_i2 Q8BW94 DYH3_MOUSE 0 GO:0005524; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR026983; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 3, axonemal (Axonemal beta dynein heavy chain 3) (Ciliary dynein heavy chain 3)" Dnah3 Dnahc3 Mus musculus (Mouse) TR29843_c1_g1_i1 Q8TD57 DYH3_HUMAN 0 GO:0005524; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR026983; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 3, axonemal (Axonemal beta dynein heavy chain 3) (HsADHC3) (Ciliary dynein heavy chain 3) (Dnahc3-b)" DNAH3 DNAHC3B Homo sapiens (Human) TR29843_c1_g1_i2 Q27802 DYHC2_TRIGR 6.00E-76 GO:0005524; GO:0006200; GO:0016887; GO:0030031; GO:0001539; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018; GO:0007275; GO:0005886 ATP binding; ATP catabolic process; ATPase activity; cell projection assembly; ciliary or bacterial-type flagellar motility; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement; multicellular organismal development; plasma membrane IPR003593; IPR011704; IPR026983; IPR026815; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; Cytoplasmic dynein 2 heavy chain 1 (Dynein heavy chain isotype 1B) DYH1B Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla) TR29845_c1_g1_i1 Q5FW48 ASPD_XENTR 1.00E-99 GO:0009435; GO:0050661; GO:0006742; GO:0033735 NAD biosynthetic process; NADP binding; NADP catabolic process; aspartate dehydrogenase activity IPR005106; IPR002811; IPR011182; IPR016040; Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. Putative L-aspartate dehydrogenase (EC 1.4.1.21) (Aspartate dehydrogenase domain-containing protein) aspdh Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR29845_c1_g1_i5 Q5FW48 ASPD_XENTR 1.00E-99 GO:0009435; GO:0050661; GO:0006742; GO:0033735 NAD biosynthetic process; NADP binding; NADP catabolic process; aspartate dehydrogenase activity IPR005106; IPR002811; IPR011182; IPR016040; Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. Putative L-aspartate dehydrogenase (EC 1.4.1.21) (Aspartate dehydrogenase domain-containing protein) aspdh Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR29848_c0_g2_i3 Q9I073 Y2770_PSEAE 4.00E-31 GO:0009058; GO:0016853 biosynthetic process; isomerase activity IPR003719; Uncharacterized isomerase PA2770 (EC 5.1.-.-) PA2770 Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) TR29848_c0_g2_i6 P58293 Y3446_CLOAB 1.00E-13 GO:0009058; GO:0016853 biosynthetic process; isomerase activity IPR003719; Uncharacterized isomerase CA_C3446 (EC 5.1.-.-) CA_C3446 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) TR29848_c0_g2_i8 Q9DCG6 PBLD1_MOUSE 2.00E-49 GO:0009058; GO:0016853 biosynthetic process; isomerase activity IPR003719; Phenazine biosynthesis-like domain-containing protein 1 (EC 5.1.-.-) Pbld1 Mawbp2 Pbld Mus musculus (Mouse) TR29850_c0_g1_i1 Q5UQ40 UBC4_MIMIV 1.00E-10 GO:0005524; GO:0000151; GO:0004842; GO:0008270 ATP binding; ubiquitin ligase complex; ubiquitin-protein ligase activity; zinc ion binding IPR003613; IPR000608; IPR016135; IPR002035; IPR001841; IPR013083; IPR024766; Protein modification; protein ubiquitination. Probable bifunctional E2/E3 enzyme R795 [Includes: E3 ubiquitin-protein ligase (EC 6.3.2.-); Ubiquitin-conjugating enzyme E2 (EC 6.3.2.19)] MIMI_R795 Acanthamoeba polyphaga mimivirus (APMV) TR29850_c0_g1_i2 P62878 RBX1_MOUSE 7.00E-62 GO:0031462; GO:0031463; GO:0031464; GO:0031465; GO:0031466; GO:0006281; GO:0019788; GO:0019005; GO:0031146; GO:0005680; GO:0005829; GO:0008190; GO:0006513; GO:0045116; GO:0004842; GO:0008270 Cul2-RING ubiquitin ligase complex; Cul3-RING ubiquitin ligase complex; Cul4A-RING ubiquitin ligase complex; Cul4B-RING ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex; DNA repair; NEDD8 ligase activity; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; anaphase-promoting complex; cytosol; eukaryotic initiation factor 4E binding; protein monoubiquitination; protein neddylation; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; IPR024766; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase RBX1 (EC 6.3.2.-) (RING finger protein 75) (RING-box protein 1) (Rbx1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed]" Rbx1 Mus musculus (Mouse) TR29852_c2_g1_i1 Q4UKI1 Y1099_RICFE 2.00E-08 IPR002110; IPR020683; Putative ankyrin repeat protein RF_1099 RF_1099 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR29852_c3_g1_i1 Q9NU02 ANKR5_HUMAN 1.00E-41 GO:0005509 calcium ion binding IPR002110; IPR020683; IPR011992; IPR002048; Ankyrin repeat and EF-hand domain-containing protein 1 (Ankyrin repeat domain-containing protein 5) ANKEF1 ANKRD5 Homo sapiens (Human) TR29854_c2_g1_i1 Q8VDL4 ADPGK_MOUSE 2.00E-52 GO:0043843; GO:0005576; GO:0006096; GO:0046872 ADP-specific glucokinase activity; extracellular region; glycolysis; metal ion binding IPR007666; Carbohydrate degradation; glycolysis. ADP-dependent glucokinase (ADP-GK) (ADPGK) (EC 2.7.1.147) Adpgk Mus musculus (Mouse) TR29860_c0_g1_i1 P18709 VITA2_XENLA 3.00E-06 GO:0005319; GO:0045735 lipid transporter activity; nutrient reservoir activity IPR015819; IPR001747; IPR015816; IPR015258; IPR015255; IPR015817; IPR015818; IPR011030; IPR001846; Vitellogenin-A2 (VTG A2) [Cleaved into: Lipovitellin I; Lipovitellin II; Phosvitin] Xenopus laevis (African clawed frog) TR29860_c2_g1_i1 Q9U943 APLP_LOCMI 6.00E-62 GO:0016055; GO:0005576; GO:0008289; GO:0005319 Wnt receptor signaling pathway; extracellular region; lipid binding; lipid transporter activity IPR015819; IPR001747; IPR009454; IPR015816; IPR015255; IPR015817; IPR015818; IPR011030; IPR001846; Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)] Locusta migratoria (Migratory locust) TR29860_c2_g1_i2 Q9U943 APLP_LOCMI 6.00E-62 GO:0016055; GO:0005576; GO:0008289; GO:0005319 Wnt receptor signaling pathway; extracellular region; lipid binding; lipid transporter activity IPR015819; IPR001747; IPR009454; IPR015816; IPR015255; IPR015817; IPR015818; IPR011030; IPR001846; Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)] Locusta migratoria (Migratory locust) TR29860_c3_g1_i1 Q91062 VIT_ICHUN 2.00E-06 GO:0005319; GO:0045735 lipid transporter activity; nutrient reservoir activity IPR015819; IPR001747; IPR015816; IPR015258; IPR015255; IPR015817; IPR015818; IPR011030; IPR001846; Vitellogenin (VTG) [Cleaved into: Lipovitellin LV-1N; Lipovitellin LV-1C; Lipovitellin LV-2] Ichthyomyzon unicuspus (Silver lamprey) TR29862_c0_g1_i2 Q78S06 SYS1_MOUSE 2.00E-45 GO:0000139; GO:0016021; GO:0015031 Golgi membrane; integral to membrane; protein transport IPR016973; IPR019185; Protein SYS1 homolog Sys1 Mus musculus (Mouse) TR29866_c0_g1_i1 Q23445 SAR1_CAEEL 5.00E-62 GO:0005525; GO:0005794; GO:0005783; GO:0006886; GO:0016192 GTP binding; Golgi apparatus; endoplasmic reticulum; intracellular protein transport; vesicle-mediated transport IPR027417; IPR005225; IPR006689; IPR006687; GTP-binding protein SAR1 ZK180.4 Caenorhabditis elegans TR29866_c0_g1_i2 Q01474 SAR1B_ARATH 7.00E-61 GO:0006888; GO:0005525; GO:0005794; GO:0005829; GO:0005783; GO:0019898; GO:0006886; GO:0005886 ER to Golgi vesicle-mediated transport; GTP binding; Golgi apparatus; cytosol; endoplasmic reticulum; extrinsic to membrane; intracellular protein transport; plasma membrane IPR027417; IPR005225; IPR006689; IPR006687; GTP-binding protein SAR1B SAR1B SAR1 At1g56330 F14G9.6 Arabidopsis thaliana (Mouse-ear cress) TR29871_c3_g1_i1 P31843 RRPO_OENBE 1.00E-28 GO:0003723; GO:0006278; GO:0003964; GO:0003968; GO:0005739 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; RNA-directed RNA polymerase activity; mitochondrion IPR000477; RNA-directed DNA polymerase homolog (EC 2.7.7.48) (Reverse transcriptase homolog) Oenothera berteriana (Bertero's evening primrose) (Oenothera berteroana) TR29871_c5_g1_i1 Q77373 POL_HV1AN 3.00E-07 GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0075713; GO:0004533; GO:0030430; GO:0042025; GO:0020002; GO:0039651; GO:0016020; GO:0090305; GO:0006508; GO:0004523; GO:0005198; GO:0039604; GO:0046718; GO:0019013; GO:0075732; GO:0046797; GO:0008270 DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; establishment of integrated proviral latency; exoribonuclease H activity; host cell cytoplasm; host cell nucleus; host cell plasma membrane; induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process; membrane; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; structural molecule activity; suppression by virus of host translation; viral entry into host cell; viral nucleocapsid; viral penetration into host nucleus; viral procapsid maturation; zinc ion binding IPR001969; IPR000721; IPR001037; IPR001584; IPR017856; IPR003308; IPR000071; IPR012344; IPR018061; IPR001995; IPR021109; IPR008916; IPR008919; IPR010999; IPR012337; IPR002156; IPR000477; IPR010659; IPR010661; IPR001878; Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide p2; Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN)] gag-pol Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1) TR29871_c6_g1_i1 Q5DTZ0 NYNRI_MOUSE 2.00E-23 GO:0015074; GO:0016021; GO:0003676 DNA integration; integral to membrane; nucleic acid binding IPR001584; IPR021869; IPR012337; Protein NYNRIN (NYN domain and retroviral integrase catalytic domain-containing protein) (Pol-like protein) Nynrin Kiaa1305 Mus musculus (Mouse) TR29871_c6_g5_i1 P04323 POL3_DROME 7.00E-54 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR29873_c4_g1_i1 Q9NXS3 KLH28_HUMAN 5.00E-17 IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR015916; IPR017096; IPR006652; Kelch-like protein 28 (BTB/POZ domain-containing protein 5) KLHL28 BTBD5 Homo sapiens (Human) TR29874_c0_g2_i1 O29712 RL11_ARCFU 3.00E-12 GO:0070180; GO:0005840; GO:0003735; GO:0006412 LSU rRNA binding; ribosome; structural constituent of ribosome; translation IPR000911; IPR020786; IPR020783; IPR020785; IPR020784; 50S ribosomal protein L11 rpl11 AF_0538 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) TR29874_c0_g4_i1 P23358 RL12_RAT 2.00E-53 GO:0003723; GO:0005840; GO:0003735; GO:0006412 RNA binding; ribosome; structural constituent of ribosome; translation IPR000911; IPR020783; IPR020785; IPR020784; 60S ribosomal protein L12 Rpl12 Rattus norvegicus (Rat) TR29875_c0_g1_i1 Q5XIY8 PAXI1_DANRE 1.00E-25 GO:0006281; GO:0005634; GO:0006355; GO:0006351 "DNA repair; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001357; PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein) paxip1 zgc:92593 Danio rerio (Zebrafish) (Brachydanio rerio) TR29875_c2_g1_i1 A0JNA8 PAXI1_BOVIN 1.00E-44 GO:0006310; GO:0006281; GO:0016363; GO:0006355; GO:0006351 "DNA recombination; DNA repair; nuclear matrix; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001357; PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein) PAXIP1 Bos taurus (Bovine) TR29875_c4_g1_i1 A0JNA8 PAXI1_BOVIN 5.00E-55 GO:0006310; GO:0006281; GO:0016363; GO:0006355; GO:0006351 "DNA recombination; DNA repair; nuclear matrix; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001357; PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein) PAXIP1 Bos taurus (Bovine) TR29875_c5_g1_i1 O04251 Y4211_ARATH 4.00E-07 IPR001357; BRCT domain-containing protein At4g02110 At4g02110 T10M13.12 Arabidopsis thaliana (Mouse-ear cress) TR29876_c0_g1_i1 Q91YL7 PG2IP_MOUSE 2.00E-67 GO:0006506; GO:0016021 GPI anchor biosynthetic process; integral to membrane IPR005135; IPR027317; PGAP2-interacting protein (Cell wall biogenesis protein 43 C-terminal homolog) Cwh43 Pgap2ip Mus musculus (Mouse) TR29877_c1_g1_i1 Q6GQ71 NUF2B_XENLA 9.00E-16 GO:0031262; GO:0051301; GO:0000777; GO:0007067; GO:0005634 Ndc80 complex; cell division; condensed chromosome kinetochore; mitosis; nucleus IPR005549; Kinetochore protein Nuf2-B (Cell division cycle-associated protein 1-B) nuf2-b cdca1-b Xenopus laevis (African clawed frog) TR29880_c1_g1_i1 Q5T2E6 CJ076_HUMAN 1.00E-46 GO:0016021 integral to membrane IPR016024; IPR013636; UPF0668 protein C10orf76 C10orf76 Homo sapiens (Human) TR29881_c0_g1_i4 O75943 RAD17_HUMAN 6.00E-51 GO:0005524; GO:0000077; GO:0006281; GO:0006260; GO:0000076; GO:0007093; GO:0008156; GO:0005654; GO:0017111; GO:0042325 Q9UM11 ATP binding; DNA damage checkpoint; DNA repair; DNA replication; DNA replication checkpoint; mitotic cell cycle checkpoint; negative regulation of DNA replication; nucleoplasm; nucleoside-triphosphatase activity; regulation of phosphorylation IPR003593; IPR004582; IPR018324; IPR027417; Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) RAD17 R24L Homo sapiens (Human) TR29883_c0_g1_i1 P82596 PLC_HALLA 4.00E-11 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR29885_c0_g1_i1 O95620 DUS4L_HUMAN 6.00E-146 GO:0050660; GO:0017150; GO:0002943 flavin adenine dinucleotide binding; tRNA dihydrouridine synthase activity; tRNA dihydrouridine synthesis IPR013785; IPR001269; IPR018517; tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (EC 1.3.1.-) (pp35) (tRNA-dihydrouridine synthase 4-like) DUS4L Homo sapiens (Human) TR29885_c0_g1_i2 Q87KU1 DUSB_VIBPA 2.00E-21 GO:0050660; GO:0017150; GO:0002943 flavin adenine dinucleotide binding; tRNA dihydrouridine synthase activity; tRNA dihydrouridine synthesis IPR013785; IPR024036; IPR004652; IPR001269; IPR018517; tRNA-dihydrouridine synthase B (EC 1.-.-.-) dusB VP2884 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) TR29885_c0_g1_i3 Q54CU9 DUS3L_DICDI 3.00E-17 GO:0005737; GO:0050660; GO:0046872; GO:0005634; GO:0017150 cytoplasm; flavin adenine dinucleotide binding; metal ion binding; nucleus; tRNA dihydrouridine synthase activity IPR013785; IPR001269; IPR018517; IPR000571; tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3-like) dus3l DDB_G0292686 Dictyostelium discoideum (Slime mold) TR29885_c0_g1_i4 Q9HUW1 DUSB_PSEAE 5.00E-23 GO:0050660; GO:0017150; GO:0002943 flavin adenine dinucleotide binding; tRNA dihydrouridine synthase activity; tRNA dihydrouridine synthesis IPR013785; IPR024036; IPR004652; IPR001269; IPR018517; tRNA-dihydrouridine synthase B (EC 1.-.-.-) dusB PA4852 Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) TR29890_c0_g1_i1 P80020 FABP6_RAT 1.00E-07 GO:0005829; GO:0005504; GO:0008202; GO:0005215 cytosol; fatty acid binding; steroid metabolic process; transporter activity IPR012674; IPR011038; IPR000463; Gastrotropin (GT) (14 kDa bile acid-binding protein) (Fatty acid-binding protein 6) (I-BABP) (Ileal lipid-binding protein) (ILBP) (Intestinal 15 kDa protein) (I-15P) Fabp6 Ilbp Illbp Rattus norvegicus (Rat) TR29892_c0_g2_i1 Q2L875 TCTP_TRIPS 1.00E-08 GO:0005737 cytoplasm IPR011057; IPR011323; IPR018105; Translationally-controlled tumor protein homolog (TCTP) Trichinella pseudospiralis (Parasitic roundworm) TR29893_c2_g1_i2 Q5U2U6 LITFL_RAT 2.00E-10 GO:0042771; GO:0005634; GO:0033209 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; nucleus; tumor necrosis factor-mediated signaling pathway IPR006629; Cell death-inducing p53-target protein 1 (LITAF-like protein) Cdip1 Rattus norvegicus (Rat) TR29894_c0_g1_i1 O77408 OAR1_LYMST 5.00E-53 GO:0016907; GO:0007213; GO:0005887 G-protein coupled acetylcholine receptor activity; G-protein coupled acetylcholine receptor signaling pathway; integral to plasma membrane IPR000276; IPR017452; IPR000995; Octopamine receptor 1 (OA1) Lymnaea stagnalis (Great pond snail) TR29894_c0_g2_i1 Q93126 GPR9_BALAM 5.00E-54 GO:0004935; GO:0071875; GO:0016021; GO:0005886 adrenergic receptor activity; adrenergic receptor signaling pathway; integral to membrane; plasma membrane IPR002233; IPR000276; IPR017452; Probable G-protein coupled receptor No9 Amphibalanus amphitrite (Striped barnacle) (Balanus amphitrite) TR29894_c1_g1_i2 P34973 DRD2B_XENLA 3.00E-18 GO:0007195; GO:0004935; GO:0071875; GO:0004952; GO:0005887 adenylate cyclase-inhibiting dopamine receptor signaling pathway; adrenergic receptor activity; adrenergic receptor signaling pathway; dopamine neurotransmitter receptor activity; integral to plasma membrane IPR002233; IPR001922; IPR000929; IPR000276; IPR017452; D(2) dopamine receptor B (D2R-B) (D2R 2) (Fragment) drd2-b Xenopus laevis (African clawed frog) TR29895_c0_g1_i1 P98063 BMP1_MOUSE 4.00E-09 GO:0005794; GO:0005509; GO:0051216; GO:0030154; GO:0005615; GO:0004222; GO:0001503; GO:0061036; GO:0005578; GO:0006508; GO:0008270 Golgi apparatus; calcium ion binding; cartilage development; cell differentiation; extracellular space; metalloendopeptidase activity; ossification; positive regulation of cartilage development; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP) Bmp1 Mus musculus (Mouse) TR29897_c0_g2_i1 P41824 YBOXH_APLCA 5.00E-52 GO:0003677; GO:0003723; GO:0005634; GO:0006355; GO:0006351 "DNA binding; RNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019844; IPR011129; IPR002059; IPR012340; Y-box factor homolog (APY1) Aplysia californica (California sea hare) TR29899_c0_g1_i2 Q62897 KCND3_RAT 4.00E-19 GO:0005250; GO:0030425; GO:0005887; GO:0046872; GO:0043025; GO:0097038; GO:0051260; GO:0042383; GO:0008076 A-type (transient outward) potassium channel activity; dendrite; integral to plasma membrane; metal ion binding; neuronal cell body; perinuclear endoplasmic reticulum; protein homooligomerization; sarcolemma; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003975; IPR004056; IPR024587; IPR021645; IPR003131; IPR028325; Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3) Kcnd3 Rattus norvegicus (Rat) TR29899_c1_g1_i1 P22001 KCNA3_HUMAN 1.00E-29 GO:0005251; GO:0045121; GO:0015271; GO:0051260; GO:0007268; GO:0008076 delayed rectifier potassium channel activity; membrane raft; outward rectifier potassium channel activity; protein homooligomerization; synaptic transmission; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003972; IPR004050; IPR003131; IPR028325; Potassium voltage-gated channel subfamily A member 3 (HGK5) (HLK3) (HPCN3) (Voltage-gated K(+) channel HuKIII) (Voltage-gated potassium channel subunit Kv1.3) KCNA3 HGK5 Homo sapiens (Human) TR29899_c1_g1_i2 P22001 KCNA3_HUMAN 2.00E-29 GO:0005251; GO:0045121; GO:0015271; GO:0051260; GO:0007268; GO:0008076 delayed rectifier potassium channel activity; membrane raft; outward rectifier potassium channel activity; protein homooligomerization; synaptic transmission; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003972; IPR004050; IPR003131; IPR028325; Potassium voltage-gated channel subfamily A member 3 (HGK5) (HLK3) (HPCN3) (Voltage-gated K(+) channel HuKIII) (Voltage-gated potassium channel subunit Kv1.3) KCNA3 HGK5 Homo sapiens (Human) TR29900_c0_g1_i1 Q9D0U1 DTWD2_MOUSE 8.00E-30 IPR005636; DTW domain-containing protein 2 Dtwd2 Mus musculus (Mouse) TR29901_c0_g1_i2 A1A4J8 SCO1_BOVIN 9.00E-84 GO:0006878; GO:0005507; GO:0006825; GO:0005743; GO:0008535 cellular copper ion homeostasis; copper ion binding; copper ion transport; mitochondrial inner membrane; respiratory chain complex IV assembly IPR003782; IPR017276; IPR012336; "Protein SCO1 homolog, mitochondrial" SCO1 SCOD1 Bos taurus (Bovine) TR29903_c0_g1_i1 P55935 RS9_DROME 9.00E-21 GO:0000022; GO:0000228; GO:0005730; GO:0019843; GO:0005840; GO:0015935; GO:0003735; GO:0006412 mitotic spindle elongation; nuclear chromosome; nucleolus; rRNA binding; ribosome; small ribosomal subunit; structural constituent of ribosome; translation IPR022801; IPR005710; IPR001912; IPR018079; IPR002942; 40S ribosomal protein S9 RpS9 CG3395 Drosophila melanogaster (Fruit fly) TR29903_c0_g2_i1 P29314 RS9_RAT 1.00E-105 GO:0022627; GO:0019843; GO:0003735; GO:0006412 cytosolic small ribosomal subunit; rRNA binding; structural constituent of ribosome; translation IPR022801; IPR005710; IPR001912; IPR018079; IPR002942; 40S ribosomal protein S9 Rps9 Rattus norvegicus (Rat) TR29904_c0_g1_i2 Q68EK9 CDC26_DANRE 1.00E-13 GO:0005680; GO:0031145; GO:0051301; GO:0007067; GO:0000278; GO:0070979; GO:0007346; GO:0030071 anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitosis; mitotic cell cycle; protein K11-linked ubiquitination; regulation of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition IPR018860; Protein modification; protein ubiquitination. Anaphase-promoting complex subunit CDC26 (Cell division cycle protein 26 homolog) cdc26 si:dkey-190c14.5 zgc:100965 Danio rerio (Zebrafish) (Brachydanio rerio) TR29905_c1_g1_i1 Q28EL0 CCYL1_XENTR 1.00E-49 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IPR013763; IPR006671; IPR012399; Cyclin-Y-like protein 1 ccnyl1 TGas141j24.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR29905_c2_g1_i1 A8MT82 CTLFB_HUMAN 2.00E-11 GO:0008060; GO:0005543; GO:0043547; GO:0032312; GO:0008270 ARF GTPase activator activity; phospholipid binding; positive regulation of GTPase activity; regulation of ARF GTPase activity; zinc ion binding IPR002110; IPR020683; IPR001164; IPR011993; IPR001849; Putative centaurin-gamma-like family member 11P CTGLF11P Homo sapiens (Human) TR29906_c2_g1_i1 Q14191 WRN_HUMAN 5.00E-143 GO:0043138; GO:0008408; GO:0005524; GO:0043140; GO:0004003; GO:0006310; GO:0000731; GO:0051880; GO:0000403; GO:0006284; GO:0000405; GO:0007569; GO:0071480; GO:0009267; GO:0005813; GO:0006302; GO:0009378; GO:0000287; GO:0030145; GO:0010259; GO:0005730; GO:0032066; GO:0005654; GO:0051345; GO:0032403; GO:0042803; GO:0042981; GO:0040009; GO:0031297; GO:0001302; GO:0010225; GO:0006979; GO:0000723 P54132; P39748; P09874; P43351; P27694; Q96EB6; Q15554; P04637; P12956 3'-5' DNA helicase activity; 3'-5' exonuclease activity; ATP binding; ATP-dependent 3'-5' DNA helicase activity; ATP-dependent DNA helicase activity; DNA recombination; DNA synthesis involved in DNA repair; G-quadruplex DNA binding; Y-form DNA binding; base-excision repair; bubble DNA binding; cell aging; cellular response to gamma radiation; cellular response to starvation; centrosome; double-strand break repair; four-way junction helicase activity; magnesium ion binding; manganese ion binding; multicellular organismal aging; nucleolus; nucleolus to nucleoplasm transport; nucleoplasm; positive regulation of hydrolase activity; protein complex binding; protein homodimerization activity; regulation of apoptotic process; regulation of growth rate; replication fork processing; replicative cell aging; response to UV-C; response to oxidative stress; telomere maintenance IPR002562; IPR011545; IPR004589; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR012337; IPR018982; IPR011991; "Werner syndrome ATP-dependent helicase (EC 3.6.4.12) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2)" WRN RECQ3 RECQL2 Homo sapiens (Human) TR29909_c1_g2_i1 Q9NUV9 GIMA4_HUMAN 3.00E-52 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR29910_c0_g1_i1 Q99NA2 ATOH8_MOUSE 2.00E-25 GO:0003677; GO:0030154; GO:0007399; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cell differentiation; nervous system development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011598; Protein atonal homolog 8 (Helix-loop-helix protein mATH-6) (mATH6) (Okadin) Atoh8 Ath6 Mus musculus (Mouse) TR29912_c0_g1_i1 Q9Y547 HSB11_HUMAN 1.00E-40 GO:0007155; GO:0005929; GO:0030992; GO:0006950 cell adhesion; cilium; intraflagellar transport particle B; response to stress IPR000421; IPR008979; Intraflagellar transport protein 25 homolog (Heat shock protein beta-11) (Hspb11) (Placental protein 25) (PP25) HSPB11 C1orf41 IFT25 HSPC034 Homo sapiens (Human) TR29913_c1_g1_i3 Q6ZMV9 KIF6_HUMAN 5.00E-07 GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0007018 Q92624 ATP binding; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF6 KIF6 C6orf102 Homo sapiens (Human) TR29915_c1_g1_i1 P73789 PPI2_SYNY3 2.00E-43 GO:0003755; GO:0006457; GO:0000413 peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase slr1251 (PPIase slr1251) (EC 5.2.1.8) (Rotamase slr1251) slr1251 Synechocystis sp. (strain PCC 6803 / Kazusa) TR29915_c2_g1_i1 P24367 PPIB_CHICK 1.00E-47 GO:0005788; GO:0042277; GO:0003755; GO:0006457; GO:0000413 endoplasmic reticulum lumen; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB Gallus gallus (Chicken) TR29916_c1_g1_i2 Q6DGK9 CK049_DANRE 3.00E-87 UPF0705 protein C11orf49 homolog zgc:92873 Danio rerio (Zebrafish) (Brachydanio rerio) TR29919_c1_g1_i1 Q9NYA1 SPHK1_HUMAN 8.00E-10 GO:0051084; GO:0005524; GO:0017050; GO:0003677; GO:0003951; GO:0001568; GO:0007420; GO:0019722; GO:0005516; GO:0005829; GO:0004143; GO:0006954; GO:0000287; GO:0043066; GO:0005634; GO:0005886; GO:0042346; GO:0051092; GO:0045766; GO:0030307; GO:0030335; GO:0048146; GO:0045931; GO:0031398; GO:0045987; GO:0007205; GO:0032651; GO:0010803; GO:0008481; GO:0046521; GO:0030148; GO:0006670 P07858; P68104; Q14192; Q2M3C7; Q9Y4K3 'de novo' posttranslational protein folding; ATP binding; D-erythro-sphingosine kinase activity; DNA binding; NAD+ kinase activity; blood vessel development; brain development; calcium-mediated signaling; calmodulin binding; cytosol; diacylglycerol kinase activity; inflammatory response; magnesium ion binding; negative regulation of apoptotic process; nucleus; plasma membrane; positive regulation of NF-kappaB import into nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of angiogenesis; positive regulation of cell growth; positive regulation of cell migration; positive regulation of fibroblast proliferation; positive regulation of mitotic cell cycle; positive regulation of protein ubiquitination; positive regulation of smooth muscle contraction; protein kinase C-activating G-protein coupled receptor signaling pathway; regulation of interleukin-1 beta production; regulation of tumor necrosis factor-mediated signaling pathway; sphinganine kinase activity; sphingoid catabolic process; sphingolipid biosynthetic process; sphingosine metabolic process IPR016064; IPR001206; Sphingosine kinase 1 (SK 1) (SPK 1) (EC 2.7.1.91) SPHK1 SPHK SPK Homo sapiens (Human) TR29919_c2_g2_i2 Q8K4Q7 CERK1_MOUSE 8.00E-15 GO:0005524; GO:0003951; GO:0001729; GO:0006672; GO:0004143; GO:0016021; GO:0000287; GO:0005739; GO:0005634; GO:0007205 ATP binding; NAD+ kinase activity; ceramide kinase activity; ceramide metabolic process; diacylglycerol kinase activity; integral to membrane; magnesium ion binding; mitochondrion; nucleus; protein kinase C-activating G-protein coupled receptor signaling pathway IPR016064; IPR001206; Ceramide kinase (mCERK) (EC 2.7.1.138) (Acylsphingosine kinase) Cerk Mus musculus (Mouse) TR29921_c0_g1_i2 P19536 COX5B_MOUSE 1.00E-09 GO:0004129; GO:0046872; GO:0005743 cytochrome-c oxidase activity; metal ion binding; mitochondrial inner membrane IPR002124; IPR020893; "Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb)" Cox5b Mus musculus (Mouse) TR29922_c3_g1_i2 Q6P5D8 SMHD1_MOUSE 3.00E-31 GO:0005524; GO:0001740; GO:0051276; GO:0060821 ATP binding; Barr body; chromosome organization; inactivation of X chromosome by DNA methylation IPR003594; IPR010935; Structural maintenance of chromosomes flexible hinge domain-containing protein 1 Smchd1 Kiaa0650 Mus musculus (Mouse) TR29923_c1_g1_i1 Q6NRC7 TBC23_XENLA 1.00E-111 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; IPR001763; TBC1 domain family member 23 tbc1d23 Xenopus laevis (African clawed frog) TR29923_c2_g1_i1 Q5F415 TBC23_CHICK 3.00E-110 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; IPR001763; TBC1 domain family member 23 TBC1D23 RCJMB04_3n7 Gallus gallus (Chicken) TR29924_c0_g1_i1 P91917 TG210_CAEEL 8.00E-176 GO:0005524; GO:0005525; GO:0005783; GO:0016787 ATP binding; GTP binding; endoplasmic reticulum; hydrolase activity IPR012675; IPR004396; IPR013029; IPR006073; IPR027417; IPR012676; IPR023192; Obg-like ATPase 1 tag-210 W08E3.3 Caenorhabditis elegans TR29926_c0_g1_i1 O94985 CSTN1_HUMAN 1.00E-15 GO:0000139; GO:0005509; GO:0030054; GO:0042995; GO:0005789; GO:0005576; GO:0007156; GO:0016021; GO:0005634; GO:0045211 Q8CD76 Golgi membrane; calcium ion binding; cell junction; cell projection; endoplasmic reticulum membrane; extracellular region; homophilic cell adhesion; integral to membrane; nucleus; postsynaptic membrane IPR002126; IPR015919; IPR026914; IPR008985; IPR013320; Calsyntenin-1 (Alcadein-alpha) (Alc-alpha) (Alzheimer-related cadherin-like protein) (Non-classical cadherin XB31alpha) [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)] CLSTN1 CS1 KIAA0911 Homo sapiens (Human) TR29927_c0_g1_i1 Q9Y619 ORNT1_HUMAN 2.00E-88 GO:0000064; GO:0006520; GO:0016021; GO:0005743; GO:0000066; GO:0000050 L-ornithine transmembrane transporter activity; cellular amino acid metabolic process; integral to membrane; mitochondrial inner membrane; mitochondrial ornithine transport; urea cycle IPR018108; IPR023395; Mitochondrial ornithine transporter 1 (Solute carrier family 25 member 15) SLC25A15 ORNT1 SP1855 Homo sapiens (Human) TR29931_c3_g1_i1 Q8QFP8 LIMK1_CHICK 6.00E-138 GO:0005524; GO:0005737; GO:0005925; GO:0030426; GO:0051444; GO:0005634; GO:0032233; GO:0045773; GO:0004674; GO:0008270 ATP binding; cytoplasm; focal adhesion; growth cone; negative regulation of ubiquitin-protein ligase activity; nucleus; positive regulation of actin filament bundle assembly; positive regulation of axon extension; protein serine/threonine kinase activity; zinc ion binding IPR011009; IPR001478; IPR000719; IPR017441; IPR001245; IPR001781; LIM domain kinase 1 (LIMK-1) (chLIMK1) (EC 2.7.11.1) LIMK1 Gallus gallus (Chicken) TR29931_c3_g1_i2 P53670 LIMK2_RAT 3.00E-179 GO:0005524; GO:0005801; GO:0005829; GO:0005634; GO:0004674; GO:0007286; GO:0008270 ATP binding; cis-Golgi network; cytosol; nucleus; protein serine/threonine kinase activity; spermatid development; zinc ion binding IPR011009; IPR001478; IPR000719; IPR017441; IPR001245; IPR001781; LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1) Limk2 Rattus norvegicus (Rat) TR29932_c0_g1_i1 B3EDY3 SAHH_CHLL2 0 GO:0004013; GO:0005737; GO:0006730 adenosylhomocysteinase activity; cytoplasm; one-carbon metabolic process IPR000043; IPR015878; IPR016040; IPR020082; Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. Adenosylhomocysteinase (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) ahcY Clim_1642 Chlorobium limicola (strain DSM 245 / NBRC 103803) TR29932_c0_g1_i2 O93477 SAHHB_XENLA 0 GO:0004013; GO:0006730 adenosylhomocysteinase activity; one-carbon metabolic process IPR000043; IPR015878; IPR016040; IPR020082; Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. Adenosylhomocysteinase B (AdoHcyase B) (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase B) ahcy-b ahcy2 sahh Xenopus laevis (African clawed frog) TR29933_c1_g1_i2 Q28BQ6 TMED1_XENTR 2.00E-37 GO:0005794; GO:0005789; GO:0033116; GO:0016021; GO:0005886; GO:0015031 Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; plasma membrane; protein transport IPR009038; Transmembrane emp24 domain-containing protein 1 (p24 family protein gamma-1) (p24gamma1) tmed1 TNeu055d12.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR29933_c1_g1_i4 Q5R7E6 TMED1_PONAB 4.00E-35 GO:0005794; GO:0005789; GO:0033116; GO:0016021; GO:0005886; GO:0015031 Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; plasma membrane; protein transport IPR009038; Transmembrane emp24 domain-containing protein 1 (p24 family protein gamma-1) (p24gamma1) TMED1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR29934_c0_g1_i1 P52013 CYP5_CAEEL 5.00E-80 GO:0005737; GO:0003755; GO:0006457 cytoplasm; peptidyl-prolyl cis-trans isomerase activity; protein folding IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase 5 (PPIase 5) (EC 5.2.1.8) (Cyclophilin-5) (Rotamase 5) cyn-5 cyp-5 F31C3.1 Caenorhabditis elegans TR29934_c0_g1_i2 Q27774 PPIB_SCHJA 3.00E-81 GO:0005788; GO:0042277; GO:0003755; GO:0006457; GO:0000413 endoplasmic reticulum lumen; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) Schistosoma japonicum (Blood fluke) TR29935_c0_g1_i2 Q9CQ66 TC1D2_MOUSE 5.00E-52 IPR005334; Tctex1 domain-containing protein 2 Tctex1d2 Mus musculus (Mouse) TR29935_c0_g1_i3 Q8CDY7 TC1D4_MOUSE 2.00E-13 IPR005334; Tctex1 domain-containing protein 4 Tctex1d4 Mus musculus (Mouse) TR29937_c0_g1_i1 Q9Z2Q2 CP088_MOUSE 5.00E-07 GO:0005730 nucleolus IPR028125; IPR028124; Lysine-rich nucleolar protein 1 (Testis-specific gene 118 protein) Knop1 Tsg118 Mus musculus (Mouse) TR29937_c0_g1_i2 Q9Z2Q2 CP088_MOUSE 9.00E-07 GO:0005730 nucleolus IPR028125; IPR028124; Lysine-rich nucleolar protein 1 (Testis-specific gene 118 protein) Knop1 Tsg118 Mus musculus (Mouse) TR29939_c0_g1_i2 Q9VZW5 FMAR_DROME 1.00E-12 GO:0002209; GO:0007204; GO:0005887; GO:0008345; GO:0008188 behavioral defense response; elevation of cytosolic calcium ion concentration; integral to plasma membrane; larval locomotory behavior; neuropeptide receptor activity IPR000276; IPR017452; FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) TR29942_c1_g1_i2 P41177 DHKR_STRCM 2.00E-08 GO:0017000; GO:0016491 antibiotic biosynthetic process; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Antifungal biosynthesis; monensin biosynthesis. Monensin polyketide synthase putative ketoacyl reductase (EC 1.3.1.-) (ORF5) Streptomyces cinnamonensis TR29942_c1_g1_i3 Q9QYF1 RDH11_MOUSE 4.00E-96 GO:0052650; GO:0016062; GO:0005789; GO:0016021; GO:0005622; GO:0001917; GO:0042574; GO:0004745 NADP-retinol dehydrogenase activity; adaptation of rhodopsin mediated signaling; endoplasmic reticulum membrane; integral to membrane; intracellular; photoreceptor inner segment; retinal metabolic process; retinol dehydrogenase activity IPR002198; IPR002347; IPR016040; Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (Cell line MC/9.IL4-derived protein 1) (M42C60) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short-chain aldehyde dehydrogenase) (SCALD) Rdh11 Arsdr1 Mdt1 Psdr1 Mus musculus (Mouse) TR29944_c0_g1_i1 Q9D939 ST1C2_MOUSE 1.00E-34 GO:0005764; GO:0008146 lysosome; sulfotransferase activity IPR027417; IPR000863; Sulfotransferase 1C2 (ST1C2) (EC 2.8.2.-) Sult1c2 Sult1c1 Mus musculus (Mouse) TR29947_c0_g1_i1 Q96MN5 TEAN2_HUMAN 5.00E-54 GO:0003677; GO:0005634; GO:0006351 "DNA binding; nucleus; transcription, DNA-dependent" IPR003618; IPR017923; Transcription elongation factor A N-terminal and central domain-containing protein 2 TCEANC2 C1orf83 Homo sapiens (Human) TR29948_c0_g1_i1 Q9ZCN4 Y689_RICPR 1.00E-08 GO:0016021; GO:0016740 integral to membrane; transferase activity IPR007074; Uncharacterized protein RP689 RP689 Rickettsia prowazekii (strain Madrid E) TR29948_c0_g1_i2 Q8CG64 FKRP_MOUSE 2.00E-121 GO:0005794; GO:0000139; GO:0005615; GO:0009101; GO:0016021; GO:0016485; GO:0005791; GO:0042383; GO:0016740 Golgi apparatus; Golgi membrane; extracellular space; glycoprotein biosynthetic process; integral to membrane; protein processing; rough endoplasmic reticulum; sarcolemma; transferase activity IPR007074; Fukutin-related protein (EC 2.-.-.-) Fkrp Mus musculus (Mouse) TR29949_c0_g3_i1 H2A0N4 PIF_PINMG 2.00E-13 GO:0008061; GO:0006030; GO:0005576 chitin binding; chitin metabolic process; extracellular region IPR002557; IPR002035; Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] Pinctada margaritifera (Black-lipped pearl oyster) TR29950_c1_g1_i1 O88738 BIRC6_MOUSE 7.00E-19 GO:0005794; GO:0006915; GO:0051301; GO:0004869; GO:0005768; GO:0060711; GO:0016020; GO:0005815; GO:0030496; GO:0007067; GO:0043066; GO:0008284; GO:0032465; GO:0000922; GO:0060712; GO:0005802; GO:0004842 Golgi apparatus; apoptotic process; cell division; cysteine-type endopeptidase inhibitor activity; endosome; labyrinthine layer development; membrane; microtubule organizing center; midbody; mitosis; negative regulation of apoptotic process; positive regulation of cell proliferation; regulation of cytokinesis; spindle pole; spongiotrophoblast layer development; trans-Golgi network; ubiquitin-protein ligase activity IPR001370; IPR022103; IPR000608; IPR016135; IPR015943; IPR017986; Baculoviral IAP repeat-containing protein 6 (EC 6.3.2.-) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) Birc6 Kiaa1289 Mus musculus (Mouse) TR29950_c3_g1_i2 Q6DG60 UBE2Z_DANRE 3.00E-57 GO:0005524; GO:0006915; GO:0005737; GO:0005634; GO:0004842 ATP binding; apoptotic process; cytoplasm; nucleus; ubiquitin-protein ligase activity IPR000608; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 Z (EC 6.3.2.19) (Ubiquitin carrier protein Z) (Ubiquitin-protein ligase Z) ube2z zgc:92419 Danio rerio (Zebrafish) (Brachydanio rerio) TR29951_c2_g1_i2 Q6ZMI3 GLDN_HUMAN 4.00E-22 GO:0045162; GO:0005581; GO:0005615; GO:0034113; GO:0016021; GO:0032528; GO:0005886 clustering of voltage-gated sodium channels; collagen; extracellular space; heterotypic cell-cell adhesion; integral to membrane; microvillus organization; plasma membrane IPR008160; IPR003112; Gliomedin GLDN COLM UNQ9339/PRO34011 Homo sapiens (Human) TR29952_c0_g1_i1 P50580 PA2G4_MOUSE 8.00E-111 GO:0003677; GO:0003723; GO:0005737; GO:0045892; GO:0005730; GO:0005634; GO:0006364; GO:0006417; GO:0030529; GO:0003700; GO:0006351 "DNA binding; RNA binding; cytoplasm; negative regulation of transcription, DNA-dependent; nucleolus; nucleus; rRNA processing; regulation of translation; ribonucleoprotein complex; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004545; IPR000994; IPR018349; IPR011991; Proliferation-associated protein 2G4 (IRES-specific cellular trans-acting factor 45 kDa) (ITAF45) (Mpp1) (Proliferation-associated protein 1) (Protein p38-2G4) Pa2g4 Ebp1 Plfap Mus musculus (Mouse) TR29954_c0_g1_i2 E1BD59 TRI56_BOVIN 1.00E-13 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) TR29954_c1_g1_i1 Q6E2N3 TRI33_DANRE 2.00E-09 GO:0003677; GO:0016874; GO:0005634; GO:0016567; GO:0006355; GO:0006351; GO:0008270 "DNA binding; ligase activity; nucleus; protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (Protein moonshine) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 mon Danio rerio (Zebrafish) (Brachydanio rerio) TR29954_c1_g1_i2 Q9BRZ2 TRI56_HUMAN 3.00E-13 GO:0005829; GO:0051607; GO:0032608; GO:0032481; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytosol; defense response to virus; interferon-beta production; positive regulation of type I interferon production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) TR29957_c0_g1_i2 P62313 LSM6_MOUSE 6.00E-48 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0006364; GO:0005681; GO:0008033 RNA binding; RNA splicing; cytoplasm; mRNA processing; rRNA processing; spliceosomal complex; tRNA processing IPR010920; IPR001163; IPR006649; U6 snRNA-associated Sm-like protein LSm6 Lsm6 Mus musculus (Mouse) TR29959_c0_g1_i1 O35490 BHMT1_MOUSE 4.00E-54 GO:0006579; GO:0047150; GO:0005737; GO:0008898; GO:0009086; GO:0008270 amino-acid betaine catabolic process; betaine-homocysteine S-methyltransferase activity; cytoplasm; homocysteine S-methyltransferase activity; methionine biosynthetic process; zinc ion binding IPR017226; IPR003726; Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. Betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5) Bhmt Mus musculus (Mouse) TR29961_c0_g1_i1 Q75F72 TIM13_ASHGO 7.00E-09 GO:0046872; GO:0005743; GO:0015031 metal ion binding; mitochondrial inner membrane; protein transport IPR004217; Mitochondrial import inner membrane translocase subunit TIM13 TIM13 AAL144C Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR29961_c0_g1_i2 Q9VTN3 TIM13_DROME 2.00E-25 GO:0046872; GO:0005743; GO:0015031 metal ion binding; mitochondrial inner membrane; protein transport IPR004217; Mitochondrial import inner membrane translocase subunit Tim13 Tim13 CG11611 Drosophila melanogaster (Fruit fly) TR29963_c0_g1_i1 P55215 CASP2_RAT 4.00E-06 GO:0006977; GO:0007568; GO:0006915; GO:0007420; GO:0071260; GO:0004197; GO:0001554; GO:0016020; GO:0005739; GO:0003407; GO:0005634; GO:0043525; GO:0016485; GO:0006508 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; aging; apoptotic process; brain development; cellular response to mechanical stimulus; cysteine-type endopeptidase activity; luteolysis; membrane; mitochondrion; neural retina development; nucleus; positive regulation of neuron apoptotic process; protein processing; proteolysis" IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] Casp2 Ich1 Rattus norvegicus (Rat) TR29964_c0_g2_i1 Q6PFY8 TRI45_MOUSE 6.00E-06 GO:0060348; GO:0005737; GO:0005634; GO:0008270 bone development; cytoplasm; nucleus; zinc ion binding IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) TR29964_c1_g1_i1 Q8BTM8 FLNA_MOUSE 1.00E-61 GO:0034988; GO:0031523; GO:0048365; GO:0051764; GO:0031532; GO:0051015; GO:0007195; GO:0005938; GO:0030030; GO:0005737; GO:0051220; GO:0005856; GO:0045022; GO:0001837; GO:0045184; GO:0001948; GO:0042177; GO:0043433; GO:0005634; GO:0005886; GO:0043123; GO:0042993; GO:0005080; GO:0034394; GO:0050821; GO:0043113; GO:0004871; GO:0090307; GO:0005802; GO:0008134 Q8CIH5 Fc-gamma receptor I complex binding; Myb complex; Rac GTPase binding; actin crosslink formation; actin cytoskeleton reorganization; actin filament binding; adenylate cyclase-inhibiting dopamine receptor signaling pathway; cell cortex; cell projection organization; cytoplasm; cytoplasmic sequestering of protein; cytoskeleton; early endosome to late endosome transport; epithelial to mesenchymal transition; establishment of protein localization; glycoprotein binding; negative regulation of protein catabolic process; negative regulation of sequence-specific DNA binding transcription factor activity; nucleus; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor import into nucleus; protein kinase C binding; protein localization to cell surface; protein stabilization; receptor clustering; signal transducer activity; spindle assembly involved in mitosis; trans-Golgi network; transcription factor binding IPR001589; IPR001715; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Flna Fln Fln1 Mus musculus (Mouse) TR29966_c0_g2_i1 Q96I25 SPF45_HUMAN 5.00E-75 GO:0003723; GO:0008380; GO:0006397; GO:0000166; GO:0005634; GO:0005681 O43143; O75533; Q8IWZ8 RNA binding; RNA splicing; mRNA processing; nucleotide binding; nucleus; spliceosomal complex IPR000467; IPR012677; IPR003954; IPR016967; Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) RBM17 SPF45 Homo sapiens (Human) TR29966_c0_g2_i2 Q96I25 SPF45_HUMAN 2.00E-75 GO:0003723; GO:0008380; GO:0006397; GO:0000166; GO:0005634; GO:0005681 O43143; O75533; Q8IWZ8 RNA binding; RNA splicing; mRNA processing; nucleotide binding; nucleus; spliceosomal complex IPR000467; IPR012677; IPR003954; IPR016967; Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) RBM17 SPF45 Homo sapiens (Human) TR29967_c0_g1_i3 Q21339 NAD3_CAEEL 7.00E-29 GO:0008340; GO:0015362; GO:0016021; GO:0015141 determination of adult lifespan; high affinity sodium:dicarboxylate symporter activity; integral to membrane; succinate transmembrane transporter activity IPR001898; Sodium-dependent high-affinity dicarboxylate transporter 3 (Na(+)/dicarboxylate cotransporter 3) (NaDC-3) (ceNaDC3) nac-3 indy-2 nad-2 K08E5.2 Caenorhabditis elegans TR29967_c0_g3_i1 Q9ES88 S13A2_MOUSE 1.00E-57 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR001898; Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter) Slc13a2 Nadc1 Sdct1 Mus musculus (Mouse) TR29969_c1_g1_i1 A2ARV4 LRP2_MOUSE 2.00E-07 GO:0005794; GO:0016324; GO:0031526; GO:0005509; GO:0008283; GO:0005905; GO:0030139; GO:0005783; GO:0005768; GO:0030900; GO:0016021; GO:0004872; GO:0006898; GO:0006766 P97318; Q62108; Q9Z0G0; Q9WVI9; Q9ERE9; Q9D6K5 Golgi apparatus; apical plasma membrane; brush border membrane; calcium ion binding; cell proliferation; coated pit; endocytic vesicle; endoplasmic reticulum; endosome; forebrain development; integral to membrane; receptor activity; receptor-mediated endocytosis; vitamin metabolic process IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) Lrp2 Mus musculus (Mouse) TR29973_c0_g2_i1 Q3KQ71 SCNM1_XENLA 7.00E-27 GO:0008380; GO:0006397; GO:0046872; GO:0016607 RNA splicing; mRNA processing; metal ion binding; nuclear speck IPR015880; Sodium channel modifier 1 scnm1 Xenopus laevis (African clawed frog) TR29974_c0_g1_i1 Q0VCY1 VAPA_BOVIN 3.00E-67 GO:0008219; GO:0005783; GO:0005789; GO:0016021; GO:0005874; GO:0031175; GO:0070972; GO:0005198 cell death; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; microtubule; neuron projection development; protein localization to endoplasmic reticulum; structural molecule activity IPR000535; IPR008962; IPR016763; Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) VAPA Bos taurus (Bovine) TR29975_c0_g1_i1 Q2NL11 CH074_BOVIN 4.00E-22 Uncharacterized protein C8orf74 homolog Bos taurus (Bovine) TR29976_c0_g1_i1 Q29RU9 SOX_BOVIN 6.00E-123 GO:0033514; GO:0050031; GO:0005777; GO:0008115; GO:0046653 L-lysine catabolic process to acetyl-CoA via L-pipecolate; L-pipecolate oxidase activity; peroxisome; sarcosine oxidase activity; tetrahydrofolate metabolic process IPR006076; IPR006281; Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase) PIPOX Bos taurus (Bovine) TR29977_c0_g1_i1 Q8AVY8 DH12B_XENLA 4.00E-103 GO:0005789; GO:0004303; GO:0006703; GO:0016021 endoplasmic reticulum membrane; estradiol 17-beta-dehydrogenase activity; estrogen biosynthetic process; integral to membrane IPR002198; IPR002347; IPR016040; IPR020904; Steroid biosynthesis; estrogen biosynthesis. Estradiol 17-beta-dehydrogenase 12-B (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 12-B) (17-beta-HSD 12-B) hsd17b12-b Xenopus laevis (African clawed frog) TR29977_c0_g1_i2 Q8N3Y7 RDHE2_HUMAN 9.00E-09 GO:0050908; GO:0005789; GO:0016021; GO:0043616; GO:0042574; GO:0004745; GO:0042572 detection of light stimulus involved in visual perception; endoplasmic reticulum membrane; integral to membrane; keratinocyte proliferation; retinal metabolic process; retinol dehydrogenase activity; retinol metabolic process IPR002198; IPR002347; IPR016040; Cofactor metabolism; retinol metabolism. Epidermal retinol dehydrogenase 2 (EPHD-2) (RDH-E2) (EC 1.1.1.105) (Retinal short-chain dehydrogenase reductase 2) (retSDR2) (Short-chain dehydrogenase/reductase family 16C member 5) SDR16C5 RDHE2 Homo sapiens (Human) TR29979_c1_g1_i1 P53767 VGFR1_RAT 5.00E-43 GO:0005524; GO:0000186; GO:0001525; GO:0048514; GO:0030154; GO:0016477; GO:0006935; GO:0048598; GO:0005768; GO:0005887; GO:0030522; GO:0030335; GO:0048661; GO:0046777; GO:0004716; GO:0006940; GO:0001666; GO:0048010; GO:0005021 ATP binding; activation of MAPKK activity; angiogenesis; blood vessel morphogenesis; cell differentiation; cell migration; chemotaxis; embryonic morphogenesis; endosome; integral to plasma membrane; intracellular receptor signaling pathway; positive regulation of cell migration; positive regulation of smooth muscle cell proliferation; protein autophosphorylation; receptor signaling protein tyrosine kinase activity; regulation of smooth muscle contraction; response to hypoxia; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor-activated receptor activity IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR001824; IPR009135; Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase receptor FLT) Flt1 Flt-1 Vegfr1 Rattus norvegicus (Rat) TR29979_c1_g1_i2 P42159 RTK2_GEOCY 1.00E-17 GO:0005524; GO:0016021; GO:0018108; GO:0005886; GO:0004714; GO:0007169 ATP binding; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR007110; IPR013783; IPR011009; IPR000719; IPR001245; IPR008266; IPR020635; IPR002011; Class II receptor tyrosine kinase (EC 2.7.10.1) (GCTK) TK Geodia cydonium (Sponge) TR29979_c1_g1_i3 Q91147 FGFR2_NOTVI 7.00E-47 GO:0005524; GO:0005794; GO:0006915; GO:0016023; GO:0048701; GO:0005007; GO:0016021; GO:0018108; GO:0005886; GO:0008284 ATP binding; Golgi apparatus; apoptotic process; cytoplasmic membrane-bounded vesicle; embryonic cranial skeleton morphogenesis; fibroblast growth factor-activated receptor activity; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; positive regulation of cell proliferation IPR028175; IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) FGFR2 Notophthalmus viridescens (Eastern newt) (Triturus viridescens) TR29979_c1_g1_i4 O73791 TIE2_DANRE 3.00E-33 GO:0005524; GO:0005737; GO:0005856; GO:0005925; GO:0007507; GO:0005887; GO:0018108; GO:0004714; GO:0007169 ATP binding; cytoplasm; cytoskeleton; focal adhesion; heart development; integral to plasma membrane; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000742; IPR013032; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR011009; IPR000719; IPR017441; IPR001245; IPR018941; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-2 (EC 2.7.10.1) (Tyrosine kinase with Ig and EGF homology domains-2) tie2 tie-2 Danio rerio (Zebrafish) (Brachydanio rerio) TR29981_c0_g1_i1 Q9D110 MTHFS_MOUSE 2.00E-63 GO:0030272; GO:0005524; GO:0005542; GO:0009396; GO:0005739; GO:0046653 5-formyltetrahydrofolate cyclo-ligase activity; ATP binding; folic acid binding; folic acid-containing compound biosynthetic process; mitochondrion; tetrahydrofolate metabolic process IPR002698; IPR024185; "5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate synthetase) (MTHFS) (Methenyl-THF synthetase)" Mthfs Mus musculus (Mouse) TR29981_c0_g1_i2 Q9P7W2 FTHC_SCHPO 5.00E-18 GO:0030272; GO:0005524; GO:0009396; GO:0005739 5-formyltetrahydrofolate cyclo-ligase activity; ATP binding; folic acid-containing compound biosynthetic process; mitochondrion IPR002698; IPR024185; "Probable 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate synthetase) (MTHFS) (Methenyl-THF synthetase)" SPBC1703.08c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR29981_c0_g1_i3 Q9D110 MTHFS_MOUSE 5.00E-62 GO:0030272; GO:0005524; GO:0005542; GO:0009396; GO:0005739; GO:0046653 5-formyltetrahydrofolate cyclo-ligase activity; ATP binding; folic acid binding; folic acid-containing compound biosynthetic process; mitochondrion; tetrahydrofolate metabolic process IPR002698; IPR024185; "5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate synthetase) (MTHFS) (Methenyl-THF synthetase)" Mthfs Mus musculus (Mouse) TR29984_c0_g2_i1 Q5BIM1 TRI45_BOVIN 3.00E-06 GO:0005737; GO:0005634; GO:0008270 cytoplasm; nucleus; zinc ion binding IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) TR2999_c0_g1_i1 Q5R5X3 PUM1_PONAB 6.00E-10 GO:0003723; GO:0005737; GO:0006417 RNA binding; cytoplasm; regulation of translation IPR011989; IPR016024; IPR001313; Pumilio homolog 1 PUM1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR29991_c0_g1_i1 Q9WUN2 TBK1_MOUSE 2.00E-79 GO:0005524; GO:0002218; GO:0005829; GO:0050830; GO:0051607; GO:0045087; GO:0010629; GO:0003676; GO:0043123; GO:0032727; GO:0045359; GO:0032728; GO:0045944; GO:0004674 P70347; A2A9T0; Q3TBT3 ATP binding; activation of innate immune response; cytosol; defense response to Gram-positive bacterium; defense response to virus; innate immune response; negative regulation of gene expression; nucleic acid binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon-alpha production; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; positive regulation of transcription from RNA polymerase II promoter; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (T2K) (TANK-binding kinase 1) Tbk1 Mus musculus (Mouse) TR29994_c0_g2_i1 O50655 XERD_SELRU 4.00E-08 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR29994_c0_g2_i2 O50655 XERD_SELRU 2.00E-08 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR29995_c2_g1_i1 Q9BRS8 LARP6_HUMAN 2.00E-34 GO:0005794; GO:0003723; GO:0006396; GO:0000166; GO:0005634; GO:0006417; GO:0030529 Golgi apparatus; RNA binding; RNA processing; nucleotide binding; nucleus; regulation of translation; ribonucleoprotein complex IPR002344; IPR006630; IPR012677; IPR024642; IPR011991; La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) LARP6 Homo sapiens (Human) TR29997_c0_g1_i1 O94111 DYL1_EMENI 6.00E-09 GO:0030029; GO:0048315; GO:0005868; GO:0005874; GO:0003774; GO:0030473; GO:0005643; GO:0051292; GO:0005777; GO:0043935 actin filament-based process; conidium formation; cytoplasmic dynein complex; microtubule; motor activity; nuclear migration along microtubule; nuclear pore; nuclear pore complex assembly; peroxisome; sexual sporulation resulting in formation of a cellular spore IPR019763; IPR001372; "Dynein light chain, cytoplasmic (8 kDa cytoplasmic dynein light chain)" nudG AN0420 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR29998_c1_g1_i1 Q8P3K2 FUCD_XANCP 3.00E-12 GO:0050023; GO:0046872 L-fuconate dehydratase activity; metal ion binding IPR013342; IPR013341; IPR001354; L-fuconate dehydratase (FucD) (EC 4.2.1.68) XCC4069 Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568) TR29998_c2_g1_i1 Q0BA70 RHMD_BURCM 6.00E-93 GO:0050032; GO:0009063; GO:0000287 L-rhamnonate dehydratase activity; cellular amino acid catabolic process; magnesium ion binding IPR023444; IPR018110; IPR013342; IPR013341; IPR001354; L-rhamnonate dehydratase (RhamD) (EC 4.2.1.90) rhmD Bamb_3399 Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia (strain AMMD)) TR29998_c2_g1_i2 A4FLW9 RHMD_SACEN 8.00E-93 GO:0050032; GO:0009063; GO:0000287 L-rhamnonate dehydratase activity; cellular amino acid catabolic process; magnesium ion binding IPR023444; IPR018110; IPR013342; IPR013341; IPR001354; L-rhamnonate dehydratase (RhamD) (EC 4.2.1.90) rhmD SACE_5860 Saccharopolyspora erythraea (strain NRRL 23338) TR29999_c1_g1_i2 P15384 KCNA3_RAT 8.00E-17 GO:0005251; GO:0045121; GO:0015271; GO:0005886; GO:0051260; GO:0008076 P78352 delayed rectifier potassium channel activity; membrane raft; outward rectifier potassium channel activity; plasma membrane; protein homooligomerization; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003972; IPR004050; IPR003131; IPR028325; Potassium voltage-gated channel subfamily A member 3 (RCK3) (RGK5) (Voltage-gated potassium channel subunit Kv1.3) (Voltage-gated potassium channel subunit Kv3) Kcna3 Rattus norvegicus (Rat) TR29999_c1_g1_i3 Q7TSH7 KCNF1_MOUSE 4.00E-19 GO:0005251; GO:0051260; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003971; IPR003131; IPR028325; Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) Kcnf1 Mus musculus (Mouse) TR30001_c0_g1_i1 Q99932 SPAG8_HUMAN 4.00E-18 GO:0001669; GO:0016020; GO:0005634; GO:0032092; GO:0045944 acrosomal vesicle; membrane; nucleus; positive regulation of protein binding; positive regulation of transcription from RNA polymerase II promoter IPR026124; Sperm-associated antigen 8 (HSD-1) (Sperm membrane protein 1) (SMP-1) (Sperm membrane protein BS-84) SPAG8 Homo sapiens (Human) TR30004_c4_g2_i1 Q9QUS6 TRIM1_MOUSE 3.00E-30 GO:0005813; GO:0005737; GO:0016874; GO:0005874; GO:0016567; GO:0008270 centrosome; cytoplasm; ligase activity; microtubule; protein ubiquitination; zinc ion binding IPR001870; IPR003649; IPR003879; IPR008985; IPR017903; IPR003961; IPR013783; IPR027727; IPR018355; IPR003877; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase MID2 (EC 6.3.2.-) (Midline defect 2) (Midline-2) (Tripartite motif-containing protein 1) Mid2 Fxy2 Trim1 Mus musculus (Mouse) TR30005_c4_g2_i1 A6N7Y9 PIWL1_CHICK 7.00E-84 GO:0003677; GO:0043186; GO:0033391; GO:0031047; GO:0003729; GO:0005845; GO:0007126; GO:0007275; GO:0034584; GO:0034587; GO:0005844; GO:0006417; GO:0003727; GO:0007286 DNA binding; P granule; chromatoid body; gene silencing by RNA; mRNA binding; mRNA cap binding complex; meiosis; multicellular organismal development; piRNA binding; piRNA metabolic process; polysome; regulation of translation; single-stranded RNA binding; spermatid development IPR017956; IPR003100; IPR003165; IPR012337; Piwi-like protein 1 PIWIL1 Gallus gallus (Chicken) TR30005_c5_g1_i1 Q8N539 FBCD1_HUMAN 1.00E-50 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 UNQ701/PRO1346 Homo sapiens (Human) TR30005_c5_g1_i3 O70165 FCN1_MOUSE 4.00E-48 GO:0005581; GO:0045087; GO:0046872 collagen; innate immune response; metal ion binding IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) Fcn1 Fcna Mus musculus (Mouse) TR30006_c0_g1_i1 Q66IC8 TC1D1_DANRE 2.00E-17 IPR005334; Tctex1 domain-containing protein 1 tctex1d1 zgc:101774 Danio rerio (Zebrafish) (Brachydanio rerio) TR30007_c0_g1_i1 P46718 PDCD2_MOUSE 1.00E-97 GO:0003677; GO:0006915; GO:0005737; GO:0046872; GO:0005634 DNA binding; apoptotic process; cytoplasm; metal ion binding; nucleus IPR007320; IPR002893; Programmed cell death protein 2 (Zinc finger protein Rp-8) Pdcd2 Rp8 Mus musculus (Mouse) TR30008_c0_g1_i3 P16580 GLNA_CHICK 4.00E-74 GO:0005524; GO:0004351; GO:0004356; GO:0006542; GO:0005739 ATP binding; glutamate decarboxylase activity; glutamate-ammonia ligase activity; glutamine biosynthetic process; mitochondrion IPR008147; IPR014746; IPR008146; IPR027303; IPR027302; Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate decarboxylase) (EC 4.1.1.15) (Glutamate--ammonia ligase) (p42) GLUL GLNS Gallus gallus (Chicken) TR30009_c2_g1_i1 P21571 ATP5J_RAT 6.00E-12 GO:0046034; GO:0015986; GO:0015078; GO:0000276 "ATP metabolic process; ATP synthesis coupled proton transport; hydrogen ion transmembrane transporter activity; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)" IPR008387; IPR016349; "ATP synthase-coupling factor 6, mitochondrial (ATPase subunit F6)" Atp5j Rattus norvegicus (Rat) TR30011_c7_g1_i2 Q9NRD8 DUOX2_HUMAN 2.00E-119 GO:0016174; GO:0016324; GO:0005509; GO:0042335; GO:0019221; GO:0020037; GO:0042446; GO:0042744; GO:0016021; GO:0004601; GO:0051591; GO:0009615; GO:0006590 NAD(P)H oxidase activity; apical plasma membrane; calcium ion binding; cuticle development; cytokine-mediated signaling pathway; heme binding; hormone biosynthetic process; hydrogen peroxide catabolic process; integral to membrane; peroxidase activity; response to cAMP; response to virus; thyroid hormone generation IPR011992; IPR018247; IPR002048; IPR013112; IPR017927; IPR013130; IPR013121; IPR010255; IPR002007; IPR019791; IPR017938; Hormone biosynthesis; thyroid hormone biosynthesis. Dual oxidase 2 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 2) (Long NOX 2) (NADH/NADPH thyroid oxidase p138-tox) (NADPH oxidase/peroxidase DUOX2) (NADPH thyroid oxidase 2) (Thyroid oxidase 2) (p138 thyroid oxidase) DUOX2 LNOX2 THOX2 Homo sapiens (Human) TR30011_c7_g2_i1 Q9ES45 DUOX2_RAT 9.00E-59 GO:0016174; GO:0016324; GO:0005509; GO:0042335; GO:0019221; GO:0020037; GO:0042446; GO:0042744; GO:0016021; GO:0004601; GO:0051591; GO:0006590 NAD(P)H oxidase activity; apical plasma membrane; calcium ion binding; cuticle development; cytokine-mediated signaling pathway; heme binding; hormone biosynthetic process; hydrogen peroxide catabolic process; integral to membrane; peroxidase activity; response to cAMP; thyroid hormone generation IPR011992; IPR018247; IPR002048; IPR013112; IPR017927; IPR013130; IPR013121; IPR010255; IPR002007; IPR019791; IPR017938; Hormone biosynthesis; thyroid hormone biosynthesis. Dual oxidase 2 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 2) (Long NOX 2) (NADH/NADPH thyroid oxidase THOX2) (Thyroid oxidase 2) Duox2 Lnox2 Thox2 Rattus norvegicus (Rat) TR30012_c0_g1_i3 Q6R7E2 IAP2_OSHVF 3.00E-34 IPR001370; Putative apoptosis inhibitor ORF87 ORF87 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) TR30014_c4_g1_i1 Q9FKP2 CCX2_ARATH 4.00E-17 GO:0015297; GO:0016021; GO:0006813; GO:0006814 antiporter activity; integral to membrane; potassium ion transport; sodium ion transport IPR004837; Cation/calcium exchanger 2 (Protein CATION EXCHANGER 8) CCX2 CAX8 At5g17850 MPI7.1 MVA3.20 MVA3_200 Arabidopsis thaliana (Mouse-ear cress) TR30014_c4_g3_i1 P34322 NCX7_CAEEL 3.00E-34 GO:0015297; GO:0006816; GO:0016021; GO:0006814 antiporter activity; calcium ion transport; integral to membrane; sodium ion transport IPR004837; Putative sodium/calcium exchanger 7 (Na(+)/Ca(2+)-exchange protein 7) ncx-7 C07A9.11 Caenorhabditis elegans TR30014_c6_g1_i2 Q80ZF7 RDH10_RAT 2.00E-81 GO:0052650; GO:0060449; GO:0044297; GO:0043583; GO:0031076; GO:0035115; GO:0048703; GO:0005789; GO:0008406; GO:0001701; GO:0016021; GO:0001656; GO:0014032; GO:0043584; GO:0060431; GO:0042574; GO:0002138; GO:0004745; GO:0007601 NADP-retinol dehydrogenase activity; bud elongation involved in lung branching; cell body; ear development; embryonic camera-type eye development; embryonic forelimb morphogenesis; embryonic viscerocranium morphogenesis; endoplasmic reticulum membrane; gonad development; in utero embryonic development; integral to membrane; metanephros development; neural crest cell development; nose development; primary lung bud formation; retinal metabolic process; retinoic acid biosynthetic process; retinol dehydrogenase activity; visual perception IPR002198; IPR002347; IPR016040; IPR020904; Cofactor metabolism; retinol metabolism. Retinol dehydrogenase 10 (EC 1.1.1.300) Rdh10 Rattus norvegicus (Rat) TR30014_c7_g1_i1 Q6AXS0 NCKX6_RAT 1.00E-60 GO:0005432; GO:0042593; GO:0032592; GO:0006851; GO:0005743; GO:0050796; GO:0050896; GO:0042383 calcium:sodium antiporter activity; glucose homeostasis; integral to mitochondrial membrane; mitochondrial calcium ion transport; mitochondrial inner membrane; regulation of insulin secretion; response to stimulus; sarcolemma IPR004837; "Sodium/potassium/calcium exchanger 6, mitochondrial (Na(+)/K(+)/Ca(2+)-exchange protein 6) (Sodium/calcium exchanger protein, mitochondrial) (Solute carrier family 24 member 6) (Solute carrier family 8 member B1)" Slc8b1 Nckx6 Nclx Slc24a6 Rattus norvegicus (Rat) TR30017_c1_g1_i1 Q09575 YRD6_CAEEL 1.00E-37 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR30020_c1_g1_i1 Q3E956 NAT9_ARATH 5.00E-11 GO:0016021; GO:0055085; GO:0005215 integral to membrane; transmembrane transport; transporter activity IPR006043; Putative nucleobase-ascorbate transporter 9 (AtNAT9) NAT9 At5g25420 F18G18.160 Arabidopsis thaliana (Mouse-ear cress) TR30020_c2_g1_i3 Q9WTW7 S23A1_RAT 6.00E-68 GO:0008520; GO:0016324; GO:0009925; GO:0007420; GO:0005903; GO:0005737; GO:0033300; GO:0005887; GO:0043229; GO:0030324; GO:0009636; GO:0070890; GO:0070904 L-ascorbate:sodium symporter activity; apical plasma membrane; basal plasma membrane; brain development; brush border; cytoplasm; dehydroascorbic acid transporter activity; integral to plasma membrane; intracellular organelle; lung development; response to toxic substance; sodium-dependent L-ascorbate transmembrane transporter activity; transepithelial L-ascorbic acid transport IPR006043; Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) Slc23a1 Svct1 Rattus norvegicus (Rat) TR30021_c0_g1_i1 B3A0P4 USP26_LOTGI 1.00E-06 GO:0005576 extracellular region Uncharacterized shell protein 26 (BMSP-like protein) (Fragment) Lottia gigantea (Giant owl limpet) TR30021_c0_g2_i2 O76217 PE1_ANOGA 1.00E-13 GO:0008061; GO:0006030; GO:0005576 chitin binding; chitin metabolic process; extracellular region IPR002557; Peritrophin-1 (AgAper-1) (Peritrophic matrix protein 1) (Peritrophin A) Aper1 AGAP006795 Anopheles gambiae (African malaria mosquito) TR30023_c0_g1_i1 Q6NYB4 MB211_DANRE 0 GO:0048568; GO:0005634 embryonic organ development; nucleus IPR024810; IPR024801; Protein mab-21-like 1 mab21l1 Danio rerio (Zebrafish) (Brachydanio rerio) TR30025_c0_g1_i1 Q9CQ86 MIEN1_MOUSE 4.00E-08 GO:0006915; GO:0045454; GO:0005829; GO:0031235; GO:0043066; GO:0030335; GO:0051491; GO:0008430 apoptotic process; cell redox homeostasis; cytosol; intrinsic to internal side of plasma membrane; negative regulation of apoptotic process; positive regulation of cell migration; positive regulation of filopodium assembly; selenium binding IPR011893; IPR012336; Migration and invasion enhancer 1 Mien1 Rdx12 Mus musculus (Mouse) TR30026_c3_g1_i1 Q0WYX8 MDGA1_CHICK 5.00E-23 GO:0046658; GO:0001764 anchored to plasma membrane; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 MDGA1 Gallus gallus (Chicken) TR30026_c3_g1_i3 Q5VYJ5 CJ112_HUMAN 1.00E-20 GO:0016021 integral to membrane IPR008985; IPR023415; IPR002172; IPR000998; MAM and LDL-receptor class A domain-containing protein C10orf112 C10orf112 Homo sapiens (Human) TR30027_c0_g1_i1 Q5SPL2 PHF12_MOUSE 6.00E-72 GO:0001106; GO:0016580; GO:0035091; GO:0017053; GO:0008270 RNA polymerase II transcription corepressor activity; Sin3 complex; phosphatidylinositol binding; transcriptional repressor complex; zinc ion binding IPR000253; IPR008984; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; PHD finger protein 12 (PHD factor 1) (Pf1) Phf12 Kiaa1523 Mus musculus (Mouse) TR30027_c1_g1_i1 Q8TDI0 CHD5_HUMAN 2.00E-11 GO:0005524; GO:0008026; GO:0003677; GO:0016568; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "ATP binding; ATP-dependent helicase activity; DNA binding; chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR012957; IPR012958; IPR023780; IPR000953; IPR016197; IPR002464; IPR009462; IPR009463; IPR014001; IPR001650; IPR027417; IPR000330; IPR019786; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.12) (ATP-dependent helicase CHD5) CHD5 KIAA0444 Homo sapiens (Human) TR30028_c0_g1_i1 Q8IUK8 CBLN2_HUMAN 6.00E-08 GO:0005615; GO:0051965 extracellular space; positive regulation of synapse assembly IPR001073; IPR008983; Cerebellin-2 CBLN2 UNQ1892/PRO4338 Homo sapiens (Human) TR30028_c0_g1_i4 Q4ZJM9 C1QL4_MOUSE 6.00E-07 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) TR30029_c1_g1_i1 Q2QI47 USH2A_MOUSE 7.00E-07 GO:0016324; GO:0005604; GO:0005518; GO:0005737; GO:0035315; GO:0060113; GO:0016021; GO:0048496; GO:0045494; GO:0050896; GO:0007605; GO:0002142; GO:0060171; GO:0007601 apical plasma membrane; basement membrane; collagen binding; cytoplasm; hair cell differentiation; inner ear receptor cell differentiation; integral to membrane; maintenance of organ identity; photoreceptor cell maintenance; response to stimulus; sensory perception of sound; stereocilia ankle link complex; stereocilium membrane; visual perception IPR008985; IPR013320; IPR002049; IPR003961; IPR013783; IPR001791; IPR008211; IPR026915; Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog) Ush2A Gm676 Mus musculus (Mouse) TR3003_c0_g1_i1 Q8Q0U0 Y045_METMA 4.00E-07 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR30030_c0_g1_i1 Q7YRA3 EXOS4_BOVIN 2.00E-123 GO:0017091; GO:0045006; GO:0005737; GO:0051607; GO:0004527; GO:0000178; GO:0071044; GO:0000460; GO:0071028; GO:0090305; GO:0005730; GO:0030307; GO:0035327 AU-rich element binding; DNA deamination; cytoplasm; defense response to virus; exonuclease activity; exosome (RNase complex); histone mRNA catabolic process; maturation of 5.8S rRNA; nuclear mRNA surveillance; nucleic acid phosphodiester bond hydrolysis; nucleolus; positive regulation of cell growth; transcriptionally active chromatin IPR001247; IPR015847; IPR027408; IPR020568; Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) EXOSC4 RRP41 Bos taurus (Bovine) TR30031_c2_g1_i1 Q9CQW0 EMC6_MOUSE 5.00E-34 GO:0072546 ER membrane protein complex IPR008504; ER membrane protein complex subunit 6 (Transmembrane protein 93) Emc6 Tmem93 Mus musculus (Mouse) TR30032_c1_g2_i1 A2AVA0 SVEP1_MOUSE 4.00E-06 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)" Svep1 Mus musculus (Mouse) TR30032_c1_g2_i2 P0C6B8 SVEP1_RAT 4.00E-06 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) TR30033_c0_g1_i1 Q9HA65 TBC17_HUMAN 2.00E-25 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR021935; IPR000195; TBC1 domain family member 17 TBC1D17 Homo sapiens (Human) TR30033_c3_g1_i1 Q9UUH7 GYP7_SCHPO 8.00E-12 GO:0005097; GO:0005829; GO:0005634; GO:0032851; GO:0016192 Rab GTPase activator activity; cytosol; nucleus; positive regulation of Rab GTPase activity; vesicle-mediated transport IPR000195; GTPase-activating protein gyp7 (GAP for ypt7) gyp7 SPAC630.05 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR30035_c1_g2_i2 Q13075 BIRC1_HUMAN 2.00E-11 GO:0005524; GO:0016323; GO:0004869; GO:0005737; GO:0006954; GO:0045087; GO:0046872; GO:0043154; GO:0043524; GO:0007399; GO:0017111 ATP binding; basolateral plasma membrane; cysteine-type endopeptidase inhibitor activity; cytoplasm; inflammatory response; innate immune response; metal ion binding; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of neuron apoptotic process; nervous system development; nucleoside-triphosphatase activity IPR003593; IPR001370; IPR007111; IPR027417; Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein) NAIP BIRC1 Homo sapiens (Human) TR30035_c1_g2_i4 O62640 PIAP_PIG 5.00E-07 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR30035_c1_g2_i6 P41437 IAP3_NPVOP 3.00E-12 GO:0006915; GO:0016874; GO:0039648; GO:0008270 apoptotic process; ligase activity; modulation by virus of host protein ubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; E3 ubiquitin-protein ligase IAP-3 (EC 6.3.2.-) (IAP-3) IAP3 IAP ORF35 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) TR30035_c1_g2_i7 Q96CA5 BIRC7_HUMAN 2.00E-08 GO:0005794; GO:0007257; GO:0006309; GO:0004869; GO:0019899; GO:0043066; GO:0005634; GO:0042127; GO:0070247; GO:0004842; GO:0008270 P55211; Q9NR28; O43464 Golgi apparatus; activation of JUN kinase activity; apoptotic DNA fragmentation; cysteine-type endopeptidase inhibitor activity; enzyme binding; negative regulation of apoptotic process; nucleus; regulation of cell proliferation; regulation of natural killer cell apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; IPR017907; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)] BIRC7 KIAP LIVIN MLIAP RNF50 UNQ5800/PRO19607/PRO21344 Homo sapiens (Human) TR30035_c1_g2_i9 A9ULZ2 BIR7B_XENLA 3.00E-17 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) TR30039_c1_g1_i1 Q5G872 SCUB2_DANRE 7.00E-06 GO:0008015; GO:0005509; GO:0009897; GO:0005615; GO:0042694; GO:0048747; GO:0007517; GO:0030514; GO:0030141; GO:0007224; GO:0001756 blood circulation; calcium ion binding; external side of plasma membrane; extracellular space; muscle cell fate specification; muscle fiber development; muscle organ development; negative regulation of BMP signaling pathway; secretory granule; smoothened signaling pathway; somitogenesis IPR026823; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR011641; "Signal peptide, CUB and EGF-like domain-containing protein 2 (Protein You)" scube2 you Danio rerio (Zebrafish) (Brachydanio rerio) TR30039_c3_g1_i1 Q60997 DMBT1_MOUSE 5.00E-20 GO:0030154; GO:0019898; GO:0001833; GO:0016021; GO:0030858; GO:0015031; GO:0005578; GO:0005044; GO:0030658; GO:0035375; GO:0042589 cell differentiation; extrinsic to membrane; inner cell mass cell proliferation; integral to membrane; positive regulation of epithelial cell differentiation; protein transport; proteinaceous extracellular matrix; scavenger receptor activity; transport vesicle membrane; zymogen binding; zymogen granule membrane IPR000859; IPR001190; IPR017448; IPR001507; IPR017977; Deleted in malignant brain tumors 1 protein (Apactin) (CRP-ductin) (Glycoprotein 300) (gp300) (Hensin) (Mucin-like glycoprotein) (Muclin) (Vomeroglandin) (p80) Dmbt1 Crpd Mus musculus (Mouse) TR30040_c0_g1_i1 A9WRT1 UBIE_RENSM 4.00E-07 GO:0009234; GO:0008168 menaquinone biosynthetic process; methyltransferase activity IPR004033; IPR023576; Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 8/8. Demethylmenaquinone methyltransferase (EC 2.1.1.163) (Menaquinone biosynthesis C-methyltransferase UbiE) ubiE RSal33209_2638 Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) TR30040_c0_g1_i2 Q8N6F8 WBS27_HUMAN 6.00E-17 Williams-Beuren syndrome chromosomal region 27 protein WBSCR27 Homo sapiens (Human) TR30041_c1_g2_i2 Q91453 STXB_SYNHO 4.00E-39 GO:0019835; GO:0005576; GO:0044179 cytolysis; extracellular region; hemolysis in other organism IPR001870; IPR003879; IPR008985; IPR006574; IPR018355; IPR003877; Stonustoxin subunit beta (SNTX subunit beta) Synanceia horrida (Estuarine stonefish) (Scorpaena horrida) TR30041_c1_g2_i3 A0ZSK3 STXA_SYNVE 9.00E-44 GO:0019835; GO:0005576; GO:0044179 cytolysis; extracellular region; hemolysis in other organism IPR001870; IPR003879; IPR008985; IPR006574; IPR018355; IPR003877; Neoverrucotoxin subunit alpha (NeoVTX subunit alpha) Synanceia verrucosa (Reef stonefish) TR30045_c0_g2_i1 Q1AE95 T183B_HUMAN 4.00E-33 GO:0016021 integral to membrane IPR001810; IPR026509; Transmembrane protein 183B TMEM183B C1orf37-dup Homo sapiens (Human) TR30045_c0_g2_i2 Q5EA86 TM183_BOVIN 2.00E-34 GO:0016021 integral to membrane IPR001810; IPR026509; Transmembrane protein 183 TMEM183 Bos taurus (Bovine) TR30045_c0_g2_i3 Q68FS7 TM183_RAT 3.00E-33 GO:0016021 integral to membrane IPR001810; IPR026509; Transmembrane protein 183 Tmem183 Rattus norvegicus (Rat) TR30045_c0_g2_i4 Q5EA86 TM183_BOVIN 9.00E-35 GO:0016021 integral to membrane IPR001810; IPR026509; Transmembrane protein 183 TMEM183 Bos taurus (Bovine) TR30047_c0_g1_i1 Q9Y6D9 MD1L1_HUMAN 9.00E-98 GO:0015629; GO:0051301; GO:0005813; GO:0000777; GO:0005829; GO:0000776; GO:0005739; GO:0007067; GO:0000090; GO:0000278; GO:0000089; GO:0072686; GO:0007094; GO:0000093; GO:0005634; GO:0090235 Q13257; P61244 actin cytoskeleton; cell division; centrosome; condensed chromosome kinetochore; cytosol; kinetochore; mitochondrion; mitosis; mitotic anaphase; mitotic cell cycle; mitotic metaphase; mitotic spindle; mitotic spindle assembly checkpoint; mitotic telophase; nucleus; regulation of metaphase plate congression IPR008672; Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) MAD1L1 MAD1 TXBP181 Homo sapiens (Human) TR30047_c0_g1_i3 Q9Y6D9 MD1L1_HUMAN 2.00E-97 GO:0015629; GO:0051301; GO:0005813; GO:0000777; GO:0005829; GO:0000776; GO:0005739; GO:0007067; GO:0000090; GO:0000278; GO:0000089; GO:0072686; GO:0007094; GO:0000093; GO:0005634; GO:0090235 Q13257; P61244 actin cytoskeleton; cell division; centrosome; condensed chromosome kinetochore; cytosol; kinetochore; mitochondrion; mitosis; mitotic anaphase; mitotic cell cycle; mitotic metaphase; mitotic spindle; mitotic spindle assembly checkpoint; mitotic telophase; nucleus; regulation of metaphase plate congression IPR008672; Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) MAD1L1 MAD1 TXBP181 Homo sapiens (Human) TR30048_c0_g1_i1 P05167 ALEU_HORVU 2.00E-23 GO:0008234; GO:0006508; GO:0005773 cysteine-type peptidase activity; proteolysis; vacuole IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Thiol protease aleurain (EC 3.4.22.16) Hordeum vulgare (Barley) TR30048_c0_g2_i1 Q3ZKN1 CATK_CANFA 3.00E-51 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR015644; IPR013201; Cathepsin K (EC 3.4.22.38) CTSK Canis familiaris (Dog) (Canis lupus familiaris) TR30048_c0_g2_i2 P09648 CATL1_CHICK 3.00E-27 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; Cathepsin L1 (EC 3.4.22.15) (Cathepsin L) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain] (Fragments) CTSL CTSL1 Gallus gallus (Chicken) TR30048_c0_g3_i1 Q26534 CATL_SCHMA 7.00E-21 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L (EC 3.4.22.15) (SMCL1) CL1 Schistosoma mansoni (Blood fluke) TR30049_c1_g1_i1 A2AJ76 HMCN2_MOUSE 9.00E-17 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 Hmcn2 Mus musculus (Mouse) TR30049_c1_g1_i2 Q9NR99 MXRA5_HUMAN 4.00E-17 GO:0005576 extracellular region IPR000483; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR003591; IPR000372; Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican) MXRA5 Homo sapiens (Human) TR30050_c0_g1_i2 Q0ZLH3 PJVK_HUMAN 5.00E-20 GO:0043025; GO:0007605 neuronal cell body; sensory perception of sound IPR007677; Pejvakin (Autosomal recessive deafness type 59 protein) DFNB59 PJVK Homo sapiens (Human) TR30051_c2_g1_i1 Q5ZLN0 LRC40_CHICK 0 IPR001611; IPR025875; IPR003591; Leucine-rich repeat-containing protein 40 LRRC40 RCJMB04_5h5 Gallus gallus (Chicken) TR30053_c0_g1_i1 Q797A7 YFNA_BACSU 5.00E-11 GO:0015171; GO:0016021; GO:0005886 amino acid transmembrane transporter activity; integral to membrane; plasma membrane IPR002293; Uncharacterized amino acid permease YfnA yfnA BSU07340 Bacillus subtilis (strain 168) TR30053_c0_g1_i3 Q9N1R6 BAT1_RABIT 2.00E-122 GO:0016021; GO:0015175; GO:0042605 integral to membrane; neutral amino acid transmembrane transporter activity; peptide antigen binding IPR002293; "B(0,+)-type amino acid transporter 1 (B(0,+)AT) (4F2-LC6) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)" SLC7A9 BAT1 Oryctolagus cuniculus (Rabbit) TR30053_c0_g1_i4 Q9QXA6 BAT1_MOUSE 3.00E-127 GO:0016021; GO:0015175; GO:0042605 integral to membrane; neutral amino acid transmembrane transporter activity; peptide antigen binding IPR002293; "B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)" Slc7a9 Bat1 Mus musculus (Mouse) TR30055_c2_g1_i1 Q63210 GNA12_RAT 3.00E-159 GO:0031683; GO:0005525; GO:0003924; GO:0007266; GO:0007188; GO:0031526; GO:0030154; GO:0007212; GO:0042733; GO:0005834; GO:0001701; GO:0007243; GO:0046872; GO:0032006; GO:0008360; GO:0010762; GO:0032434; GO:0042493; GO:0004871 G-protein beta/gamma-subunit complex binding; GTP binding; GTPase activity; Rho protein signal transduction; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; brush border membrane; cell differentiation; dopamine receptor signaling pathway; embryonic digit morphogenesis; heterotrimeric G-protein complex; in utero embryonic development; intracellular protein kinase cascade; metal ion binding; regulation of TOR signaling cascade; regulation of cell shape; regulation of fibroblast migration; regulation of proteasomal ubiquitin-dependent protein catabolic process; response to drug; signal transducer activity IPR000469; IPR001019; IPR011025; IPR027417; Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12) Gna12 Rattus norvegicus (Rat) TR30056_c0_g1_i1 Q28HL3 CO041_XENTR 4.00E-62 Uncharacterized protein C15orf41 homolog TTpA007f23.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30056_c1_g1_i3 Q3U4G0 CO041_MOUSE 1.00E-18 Uncharacterized protein C15orf41 homolog Mus musculus (Mouse) TR30059_c0_g2_i3 Q9BXJ4 C1QT3_HUMAN 5.00E-12 GO:0035356; GO:0005581; GO:0005615; GO:0045444; GO:0042593; GO:0042347; GO:0010629; GO:0045721; GO:0050728; GO:1900165; GO:0071638; GO:0070374; GO:0070165; GO:0050715; GO:0051897; GO:0070206 cellular triglyceride homeostasis; collagen; extracellular space; fat cell differentiation; glucose homeostasis; negative regulation of NF-kappaB import into nucleus; negative regulation of gene expression; negative regulation of gluconeogenesis; negative regulation of inflammatory response; negative regulation of interleukin-6 secretion; negative regulation of monocyte chemotactic protein-1 production; positive regulation of ERK1 and ERK2 cascade; positive regulation of adiponectin secretion; positive regulation of cytokine secretion; positive regulation of protein kinase B signaling cascade; protein trimerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) TR30059_c0_g2_i5 Q9BXI9 C1QT6_HUMAN 6.00E-12 GO:0005581; GO:0005615; GO:0070208 collagen; extracellular space; protein heterotrimerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 6 C1QTNF6 CTRP6 UNQ581/PRO1151 Homo sapiens (Human) TR30059_c1_g1_i1 Q5RJ80 CAPR2_DANRE 2.00E-11 GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:2000055; GO:0090263; GO:0050775; GO:0061003; GO:0040008 RNA binding; cytoplasm; dorsal/ventral pattern formation; negative regulation of translation; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of dendrite morphogenesis; positive regulation of dendritic spine morphogenesis; regulation of growth IPR001073; IPR008983; Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR30059_c2_g2_i1 P14282 CO8A1_RABIT 4.00E-06 GO:0001525; GO:0005604; GO:0007155; GO:0005581 angiogenesis; basement membrane; cell adhesion; collagen IPR001073; IPR008160; IPR008983; Collagen alpha-1(VIII) chain (Endothelial collagen) [Cleaved into: Vastatin] COL8A1 Oryctolagus cuniculus (Rabbit) TR30059_c2_g2_i2 Q8R066 C1QT4_MOUSE 2.00E-08 GO:0005615 extracellular space IPR001073; IPR008983; Complement C1q tumor necrosis factor-related protein 4 C1qtnf4 Mus musculus (Mouse) TR30059_c2_g2_i3 Q8R066 C1QT4_MOUSE 6.00E-08 GO:0005615 extracellular space IPR001073; IPR008983; Complement C1q tumor necrosis factor-related protein 4 C1qtnf4 Mus musculus (Mouse) TR3006_c0_g2_i1 B3RFR8 HYDMA_HYDVU 3.00E-15 GO:0042742; GO:0045087; GO:0016020; GO:0044218 defense response to bacterium; innate immune response; membrane; other organism cell membrane Hydramacin-1 (Hm-1) Hydra vulgaris (Hydra) (Hydra attenuata) TR30060_c1_g1_i1 Q24K15 ANGP4_BOVIN 5.00E-45 GO:0001525; GO:0005576 angiogenesis; extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) TR30060_c1_g1_i3 O70497 FCN2_MOUSE 1.00E-45 GO:0005581; GO:0001867 "collagen; complement activation, lectin pathway" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) Fcn2 Fcnb Mus musculus (Mouse) TR30060_c1_g1_i4 O43827 ANGL7_HUMAN 3.00E-42 GO:0005576; GO:0006979 extracellular region; response to oxidative stress IPR014716; IPR014715; IPR002181; Angiopoietin-related protein 7 (Angiopoietin-like factor) (Angiopoietin-like protein 7) (Cornea-derived transcript 6 protein) ANGPTL7 CDT6 UNQ313/PRO356 Homo sapiens (Human) TR30060_c1_g1_i5 O00602 FCN1_HUMAN 7.00E-47 GO:0003823; GO:0005509; GO:0030246; GO:0005581; GO:0001867; GO:0005576; GO:0008228 Q2TS39 "antigen binding; calcium ion binding; carbohydrate binding; collagen; complement activation, lectin pathway; extracellular region; opsonization" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) FCN1 FCNM Homo sapiens (Human) TR30063_c1_g1_i1 Q80UX8 ABHDD_MOUSE 1.00E-77 GO:0016787; GO:0016021 hydrolase activity; integral to membrane Alpha/beta hydrolase domain-containing protein 13 (Abhydrolase domain-containing protein 13) (EC 3.-.-.-) Abhd13 Mus musculus (Mouse) TR30063_c1_g1_i3 Q5ZJL8 ABHDD_CHICK 7.00E-77 GO:0016787; GO:0016021 hydrolase activity; integral to membrane Alpha/beta hydrolase domain-containing protein 13 (Abhydrolase domain-containing protein 13) (EC 3.-.-.-) ABHD13 RCJMB04_17d11 Gallus gallus (Chicken) TR30064_c0_g1_i2 Q91XS8 ST17B_RAT 5.00E-89 GO:0005524; GO:0015629; GO:0006915; GO:0005793; GO:0007243; GO:0005634; GO:0005886; GO:2000271; GO:0046777; GO:0004674 P61023; Q9Z1Y0 ATP binding; actin cytoskeleton; apoptotic process; endoplasmic reticulum-Golgi intermediate compartment; intracellular protein kinase cascade; nucleus; plasma membrane; positive regulation of fibroblast apoptotic process; protein autophosphorylation; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2) Stk17b Drak2 Rattus norvegicus (Rat) TR30066_c1_g1_i1 Q9QXV3 ING1_MOUSE 2.00E-20 GO:0007049; GO:0005634; GO:0045893; GO:0006606; GO:0010941; GO:0008270 "cell cycle; nucleus; positive regulation of transcription, DNA-dependent; protein import into nucleus; regulation of cell death; zinc ion binding" IPR024610; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Inhibitor of growth protein 1 Ing1 Mus musculus (Mouse) TR30069_c0_g1_i1 Q8R066 C1QT4_MOUSE 7.00E-08 GO:0005615 extracellular space IPR001073; IPR008983; Complement C1q tumor necrosis factor-related protein 4 C1qtnf4 Mus musculus (Mouse) TR30071_c0_g1_i1 Q9JKP8 CHRC1_MOUSE 4.00E-08 GO:0003887; GO:0005634; GO:0043565 DNA-directed DNA polymerase activity; nucleus; sequence-specific DNA binding IPR003958; IPR009072; Chromatin accessibility complex protein 1 (CHRAC-1) (DNA polymerase epsilon subunit p15) (NF-YC-like protein) (YC-like protein 1) (YCL1) Chrac1 Mus musculus (Mouse) TR30071_c0_g1_i2 Q9NRG0 CHRC1_HUMAN 8.00E-10 GO:0008623; GO:0003677; GO:0003887; GO:0006338; GO:0008622; GO:0043565 CHRAC; DNA binding; DNA-directed DNA polymerase activity; chromatin remodeling; epsilon DNA polymerase complex; sequence-specific DNA binding IPR003958; IPR009072; Chromatin accessibility complex protein 1 (CHRAC-1) (Chromatin accessibility complex 15 kDa protein) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15) CHRAC1 CHRAC15 Homo sapiens (Human) TR30071_c0_g1_i3 Q9NR33 DPOE4_HUMAN 5.00E-27 GO:0005671; GO:0003887; GO:0008622; GO:0043966; GO:0043565 Q9Q2G4; Q9NRF9 Ada2/Gcn5/Ada3 transcription activator complex; DNA-directed DNA polymerase activity; epsilon DNA polymerase complex; histone H3 acetylation; sequence-specific DNA binding IPR003958; IPR009072; DNA polymerase epsilon subunit 4 (EC 2.7.7.7) (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12) POLE4 Homo sapiens (Human) TR30073_c0_g1_i2 P08155 KRUH_DROME 3.00E-13 GO:0003677; GO:0046872; GO:0007552; GO:0045316; GO:0035075 DNA binding; metal ion binding; metamorphosis; negative regulation of compound eye photoreceptor development; response to ecdysone IPR007087; IPR015880; IPR013087; Krueppel homologous protein 1 Kr-h1 Kr-h CG9167 Drosophila melanogaster (Fruit fly) TR30073_c0_g1_i4 Q9ULD5 ZN777_HUMAN 2.00E-11 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR022137; IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 777 ZNF777 KIAA1285 Homo sapiens (Human) TR30074_c0_g1_i1 Q96LX7 CCD17_HUMAN 2.00E-08 Coiled-coil domain-containing protein 17 CCDC17 Homo sapiens (Human) TR30076_c0_g2_i1 Q29RL1 CF165_BOVIN 0 IPR021897; UPF0704 protein C6orf165 homolog Bos taurus (Bovine) TR30077_c3_g1_i2 Q7M3K2 PELET_DROME 1.00E-12 GO:0015074; GO:0003693; GO:0046872; GO:0016740; GO:0004803; GO:0006313 "DNA integration; P-element binding; metal ion binding; transferase activity; transposase activity; transposition, DNA-mediated" IPR022242; IPR021896; IPR006612; Transposable element P transposase (P-element transposase) (EC 2.7.7.-) (THAP domain-containing protein) (DmTHAP) T Drosophila melanogaster (Fruit fly) TR30077_c3_g1_i3 Q7M3K2 PELET_DROME 1.00E-12 GO:0015074; GO:0003693; GO:0046872; GO:0016740; GO:0004803; GO:0006313 "DNA integration; P-element binding; metal ion binding; transferase activity; transposase activity; transposition, DNA-mediated" IPR022242; IPR021896; IPR006612; Transposable element P transposase (P-element transposase) (EC 2.7.7.-) (THAP domain-containing protein) (DmTHAP) T Drosophila melanogaster (Fruit fly) TR30078_c0_g4_i1 P29190 PCKG_HAECO 2.00E-38 GO:0005525; GO:0006094; GO:0046872; GO:0004613 GTP binding; gluconeogenesis; metal ion binding; phosphoenolpyruvate carboxykinase (GTP) activity IPR018091; IPR013035; IPR008209; IPR008210; Phosphoenolpyruvate carboxykinase [GTP] (PEPCK) (EC 4.1.1.32) (Phosphoenolpyruvate carboxylase) PEPCK Haemonchus contortus (Barber pole worm) TR30081_c0_g1_i1 Q67ER4 R113A_BOVIN 2.00E-121 GO:0008270 zinc ion binding IPR000571; IPR001841; IPR013083; IPR017907; RING finger protein 113A (Zinc finger protein 183) RNF113A ZNF183 Bos taurus (Bovine) TR30082_c1_g2_i1 O70212 5HT3A_CAVPO 8.00E-14 GO:0004890; GO:0006812; GO:0030054; GO:0005230; GO:0030285; GO:0045211 GABA-A receptor activity; cation transport; cell junction; extracellular ligand-gated ion channel activity; integral to synaptic vesicle membrane; postsynaptic membrane IPR008132; IPR008133; IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; 5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor) HTR3A 5HT3R HTR3 Cavia porcellus (Guinea pig) TR30082_c4_g1_i1 P09481 ACHA3_CHICK 8.00E-18 GO:0015464; GO:0004889; GO:0005892; GO:0035095; GO:0030054; GO:0007399; GO:0045211; GO:0060084 acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; behavioral response to nicotine; cell junction; nervous system development; postsynaptic membrane; synaptic transmission involved in micturition IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 Gallus gallus (Chicken) TR30082_c7_g3_i1 Q91DM0 POLG_PVCV1 8.00E-08 GO:0003677; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508; GO:0046740; GO:0006810; GO:0008270 "DNA binding; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis; spread of virus in host, cell to cell; transport; zinc ion binding" IPR000477; IPR001878; Genome polyprotein [Cleaved into: Movement protein (MP); Capsid protein (CP); Aspartic protease (PR) (EC 3.4.23.-); Reverse transcriptase (RT) (EC 2.7.7.49)] Petunia vein clearing virus (isolate Shepherd) (PVCV) TR30082_c8_g2_i1 P86854 PLCL_MYTGA 3.00E-41 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR30082_c8_g2_i2 Q56EB1 BJCA_BOTJA 2.00E-08 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Snaclec bothrojaracin subunit alpha (BJC subunit alpha) Bothropoides jararaca (Jararaca) (Bothrops jararaca) TR30083_c0_g1_i1 A8Y5U1 CE051_DANRE 6.00E-36 UPF0600 protein C5orf51 homolog si:dkey-46a10.3 wu:fd42g01 Danio rerio (Zebrafish) (Brachydanio rerio) TR30083_c0_g1_i2 A8Y5U1 CE051_DANRE 8.00E-11 UPF0600 protein C5orf51 homolog si:dkey-46a10.3 wu:fd42g01 Danio rerio (Zebrafish) (Brachydanio rerio) TR30084_c0_g1_i2 Q90WZ0 IF20A_XENLA 1.00E-60 GO:0005794; GO:0030030; GO:0005815 Golgi apparatus; cell projection organization; microtubule organizing center IPR028172; Intraflagellar transport protein 20 homolog A ift20-a Xenopus laevis (African clawed frog) TR30085_c0_g4_i1 P29496 MCM5_YEAST 2.00E-75 GO:0005524; GO:0032508; GO:0003678; GO:0006270; GO:0003688; GO:0031261; GO:0042555; GO:0003682; GO:0006348; GO:0005737; GO:0000727; GO:0006343; GO:0031939; GO:0000784; GO:0005656; GO:0006267; GO:0030174; GO:0031298 P25651; P24279 "ATP binding; DNA duplex unwinding; DNA helicase activity; DNA replication initiation; DNA replication origin binding; DNA replication preinitiation complex; MCM complex; chromatin binding; chromatin silencing at telomere; cytoplasm; double-strand break repair via break-induced replication; establishment of chromatin silencing; negative regulation of chromatin silencing at telomere; nuclear chromosome, telomeric region; nuclear pre-replicative complex; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; regulation of DNA-dependent DNA replication initiation; replication fork protection complex" IPR003593; IPR008048; IPR018525; IPR001208; IPR027925; IPR012340; IPR027417; Minichromosome maintenance protein 5 (EC 3.6.4.12) (Cell division control protein 46) MCM5 CDC46 YLR274W L9328.1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR30085_c0_g4_i5 Q6NX31 MCM7_XENTR 0 GO:0005524; GO:0006200; GO:0003677; GO:0003678; GO:0006270; GO:0006268; GO:0042555; GO:0007049; GO:0000785; GO:0046872; GO:0005634; GO:0030174 ATP binding; ATP catabolic process; DNA binding; DNA helicase activity; DNA replication initiation; DNA unwinding involved in DNA replication; MCM complex; cell cycle; chromatin; metal ion binding; nucleus; regulation of DNA-dependent DNA replication initiation IPR003593; IPR008050; IPR018525; IPR001208; IPR027925; IPR012340; IPR027417; DNA replication licensing factor mcm7 (EC 3.6.4.12) (CDC47 homolog) (Minichromosome maintenance protein 7) mcm7 TGas137h09.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30086_c0_g1_i2 Q9HAC7 CG010_HUMAN 2.00E-173 GO:0005739; GO:0047369 mitochondrion; succinate-hydroxymethylglutarate CoA-transferase activity IPR003673; IPR023606; Succinate--hydroxymethylglutarate CoA-transferase (EC 2.8.3.13) (Dermal papilla-derived protein 13) C7orf10 DERP13 Homo sapiens (Human) TR30088_c0_g1_i1 Q5RJN4 CS066_RAT 5.00E-18 IPR026795; UPF0515 protein C19orf66 homolog Rattus norvegicus (Rat) TR30088_c0_g3_i1 A7YY07 CS066_DANRE 1.00E-37 IPR026795; UPF0515 protein C19orf66 homolog zgc:171711 Danio rerio (Zebrafish) (Brachydanio rerio) TR30090_c2_g1_i1 Q8NB59 SYT14_HUMAN 7.00E-97 GO:0008219; GO:0016021; GO:0005543 cell death; integral to membrane; phospholipid binding IPR000008; Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV) SYT14 Homo sapiens (Human) TR30092_c1_g1_i1 Q9H4Z2 ZN335_HUMAN 4.00E-15 GO:0007420; GO:0080182; GO:0046872; GO:0048812; GO:0005634; GO:0050671; GO:0002052; GO:0040029; GO:0006355; GO:0044212; GO:0006351 "brain development; histone H3-K4 trimethylation; metal ion binding; neuron projection morphogenesis; nucleus; positive regulation of lymphocyte proliferation; positive regulation of neuroblast proliferation; regulation of gene expression, epigenetic; regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) ZNF335 Homo sapiens (Human) TR30092_c1_g1_i2 Q8N393 ZN786_HUMAN 2.00E-13 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 786 ZNF786 Homo sapiens (Human) TR30092_c1_g1_i3 P28698 MZF1_HUMAN 3.00E-14 GO:0046872; GO:0005634; GO:0003700; GO:0044212; GO:0006351 "metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Myeloid zinc finger 1 (MZF-1) (Zinc finger and SCAN domain-containing protein 6) (Zinc finger protein 42) MZF1 MZF ZNF42 ZSCAN6 Homo sapiens (Human) TR30092_c1_g1_i4 P52747 ZN143_HUMAN 1.00E-13 GO:0003677; GO:0046872; GO:0005654; GO:0006357; GO:0006359; GO:0006366; GO:0006383 DNA binding; metal ion binding; nucleoplasm; regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase III promoter; transcription from RNA polymerase II promoter; transcription from RNA polymerase III promoter IPR007087; IPR015880; IPR013087; Zinc finger protein 143 (SPH-binding factor) (Selenocysteine tRNA gene transcription-activating factor) (hStaf) ZNF143 SBF STAF Homo sapiens (Human) TR30093_c3_g1_i1 Q62210 BIRC2_MOUSE 2.00E-12 GO:0035631; GO:0006915; GO:0005737; GO:0009898; GO:0070266; GO:0060546; GO:1902443; GO:0005634; GO:0001890; GO:0043123; GO:0043161; GO:0070936; GO:0070534; GO:0042981; GO:0051726; GO:2000377; GO:0006355; GO:0003713; GO:0006351; GO:0004842; GO:0008270 "CD40 receptor complex; apoptotic process; cytoplasm; internal side of plasma membrane; necroptosis; negative regulation of necroptosis; negative regulation of ripoptosome assembly involved in necroptosis; nucleus; placenta development; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; protein K63-linked ubiquitination; regulation of apoptotic process; regulation of cell cycle; regulation of reactive oxygen species metabolic process; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (Inhibitor of apoptosis protein 2) (IAP-2) (mIAP-2) (mIAP2) Birc2 Birc3 Iap2 Mus musculus (Mouse) TR30095_c5_g2_i2 O43704 ST1B1_HUMAN 2.00E-44 GO:0050427; GO:0004062; GO:0006576; GO:0005829; GO:0009812; GO:0008202; GO:0051923; GO:0008146; GO:0042403; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; aryl sulfotransferase activity; cellular biogenic amine metabolic process; cytosol; flavonoid metabolic process; steroid metabolic process; sulfation; sulfotransferase activity; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) (Sulfotransferase 1B2) (ST1B2) (Thyroid hormone sulfotransferase) SULT1B1 ST1B2 SULT1B2 Homo sapiens (Human) TR30095_c5_g2_i3 O43704 ST1B1_HUMAN 1.00E-43 GO:0050427; GO:0004062; GO:0006576; GO:0005829; GO:0009812; GO:0008202; GO:0051923; GO:0008146; GO:0042403; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; aryl sulfotransferase activity; cellular biogenic amine metabolic process; cytosol; flavonoid metabolic process; steroid metabolic process; sulfation; sulfotransferase activity; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) (Sulfotransferase 1B2) (ST1B2) (Thyroid hormone sulfotransferase) SULT1B1 ST1B2 SULT1B2 Homo sapiens (Human) TR30099_c4_g2_i1 Q9JK91 MLH1_MOUSE 3.00E-13 GO:0005524; GO:0016887; GO:0032389; GO:0032390; GO:0032407; GO:0005712; GO:0006303; GO:0032137; GO:0008630; GO:0045190; GO:0001673; GO:0007060; GO:0043060; GO:0006298; GO:0045950; GO:0000289; GO:0005654; GO:0048477; GO:0000712; GO:0003697; GO:0016446; GO:0007283; GO:0051257; GO:0007129; GO:0000795 ATP binding; ATPase activity; MutLalpha complex; MutLbeta complex; MutSalpha complex binding; chiasma; double-strand break repair via nonhomologous end joining; guanine/thymine mispair binding; intrinsic apoptotic signaling pathway in response to DNA damage; isotype switching; male germ cell nucleus; male meiosis chromosome segregation; meiotic metaphase I plate congression; mismatch repair; negative regulation of mitotic recombination; nuclear-transcribed mRNA poly(A) tail shortening; nucleoplasm; oogenesis; resolution of meiotic recombination intermediates; single-stranded DNA binding; somatic hypermutation of immunoglobulin genes; spermatogenesis; spindle midzone assembly involved in meiosis; synapsis; synaptonemal complex IPR013507; IPR014762; IPR002099; IPR011186; IPR003594; IPR020568; IPR014721; DNA mismatch repair protein Mlh1 (MutL protein homolog 1) Mlh1 Mus musculus (Mouse) TR30099_c4_g2_i2 P40692 MLH1_HUMAN 0 GO:0005524; GO:0016887; GO:0032389; GO:0032390; GO:0005712; GO:0006303; GO:0032137; GO:0008630; GO:0045190; GO:0001673; GO:0007060; GO:0043060; GO:0006298; GO:0045950; GO:0000289; GO:0048477; GO:0007131; GO:0000712; GO:0016446; GO:0007283; GO:0051257; GO:0007129; GO:0000795 P63261; P07355; Q9BX63; P07858; P17661; Q16658; Q969T7; P54278; Q13813; P62328; O75152 ATP binding; ATPase activity; MutLalpha complex; MutLbeta complex; chiasma; double-strand break repair via nonhomologous end joining; guanine/thymine mispair binding; intrinsic apoptotic signaling pathway in response to DNA damage; isotype switching; male germ cell nucleus; male meiosis chromosome segregation; meiotic metaphase I plate congression; mismatch repair; negative regulation of mitotic recombination; nuclear-transcribed mRNA poly(A) tail shortening; oogenesis; reciprocal meiotic recombination; resolution of meiotic recombination intermediates; somatic hypermutation of immunoglobulin genes; spermatogenesis; spindle midzone assembly involved in meiosis; synapsis; synaptonemal complex IPR013507; IPR014762; IPR002099; IPR011186; IPR003594; IPR020568; IPR014721; DNA mismatch repair protein Mlh1 (MutL protein homolog 1) MLH1 COCA2 Homo sapiens (Human) TR30101_c0_g2_i1 Q5RD03 ARMC6_PONAB 2.00E-124 IPR011989; IPR016024; IPR000225; Armadillo repeat-containing protein 6 ARMC6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR30101_c0_g2_i2 Q54I71 AARA_DICDI 2.00E-10 GO:0051645; GO:0045180; GO:0007155; GO:0005911; GO:0006928; GO:0034613; GO:0005813; GO:0051642; GO:0003382; GO:0061245; GO:0051495; GO:0009306; GO:0036360 Golgi localization; basal cortex; cell adhesion; cell-cell junction; cellular component movement; cellular protein localization; centrosome; centrosome localization; epithelial cell morphogenesis; establishment or maintenance of bipolar cell polarity; positive regulation of cytoskeleton organization; protein secretion; sorocarp stalk morphogenesis IPR011989; IPR016024; IPR000225; IPR001810; Protein aardvark (Suppressor of amiB protein 16) aarA aar sab6 DDB_G0288877 Dictyostelium discoideum (Slime mold) TR30101_c0_g2_i3 Q8BNU0 ARMC6_MOUSE 1.00E-40 IPR011989; IPR016024; IPR000225; Armadillo repeat-containing protein 6 Armc6 Mus musculus (Mouse) TR30103_c5_g1_i1 Q3UH68 LIMC1_MOUSE 1.00E-19 GO:0031032; GO:0008270 actomyosin structure organization; zinc ion binding IPR001997; IPR001715; IPR001781; LIM and calponin homology domains-containing protein 1 Limch1 Kiaa1102 Mus musculus (Mouse) TR30104_c1_g1_i3 P38129 TAF5_YEAST 3.00E-06 GO:0051123; GO:0000124; GO:0046695; GO:0003682; GO:0016573; GO:0032947; GO:0006355; GO:0005669; GO:0043130 Itself; Q12060; P23255; P50105; P53040 "RNA polymerase II transcriptional preinitiation complex assembly; SAGA complex; SLIK (SAGA-like) complex; chromatin binding; histone acetylation; protein complex scaffold; regulation of transcription, DNA-dependent; transcription factor TFIID complex; ubiquitin binding" IPR020472; IPR006594; IPR013720; IPR007582; IPR015943; IPR001680; IPR019775; IPR017986; Transcription initiation factor TFIID subunit 5 (TAFII-90) (TBP-associated factor 5) (TBP-associated factor 90 kDa) TAF5 TAF90 YBR198C YBR1410 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR30104_c1_g1_i4 Q8BL74 TF3C2_MOUSE 4.00E-24 GO:0003677; GO:0000127; GO:0006383 DNA binding; transcription factor TFIIIC complex; transcription from RNA polymerase III promoter IPR015943; IPR001680; IPR019775; IPR017986; General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) Gtf3c2 Kiaa0011 Mus musculus (Mouse) TR30105_c7_g1_i1 Q0V9A9 LACB2_XENTR 3.00E-65 GO:0016787; GO:0046872 hydrolase activity; metal ion binding IPR001279; Beta-lactamase-like protein 2 (EC 3.-.-.-) lactb2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30108_c4_g1_i1 Q9QXQ1 PDE7B_MOUSE 1.00E-36 GO:0004115; GO:0006198; GO:0046872; GO:0007165 "3',5'-cyclic-AMP phosphodiesterase activity; cAMP catabolic process; metal ion binding; signal transduction" IPR003607; IPR023088; IPR002073; IPR023174; "Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1." "cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.53)" Pde7b Mus musculus (Mouse) TR30117_c0_g2_i1 Q9H3U5 MFSD1_HUMAN 6.00E-18 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Major facilitator superfamily domain-containing protein 1 (Smooth muscle cell-associated protein 4) (SMAP-4) MFSD1 SMAP4 UG0581B09 Homo sapiens (Human) TR30117_c0_g2_i2 Q9DC37 MFSD1_MOUSE 2.00E-17 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Major facilitator superfamily domain-containing protein 1 Mfsd1 Mus musculus (Mouse) TR30118_c1_g1_i3 O55043 ARHG7_RAT 1.00E-10 GO:0005089; GO:0043615; GO:0005938; GO:0005737; GO:0005925; GO:0030426; GO:0005085; GO:0030027; GO:0030032; GO:0005543; GO:0043065; GO:0035023; GO:0001726; GO:0007264 P41227; Q13177 Rho guanyl-nucleotide exchange factor activity; astrocyte cell migration; cell cortex; cytoplasm; focal adhesion; growth cone; guanyl-nucleotide exchange factor activity; lamellipodium; lamellipodium assembly; phospholipid binding; positive regulation of apoptotic process; regulation of Rho protein signal transduction; ruffle; small GTPase mediated signal transduction IPR000219; IPR001331; IPR011993; IPR001849; IPR011511; IPR001452; Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) Arhgef7 Pak3bp Pixb Rattus norvegicus (Rat) TR30118_c1_g1_i4 Q9JLQ0 CD2AP_MOUSE 1.00E-41 GO:0005938; GO:0051301; GO:0005829; GO:0031941; GO:0007067; GO:0032911; GO:0005730; GO:0005886; GO:1900182; GO:2000249; GO:0001726 cell cortex; cell division; cytosol; filamentous actin; mitosis; negative regulation of transforming growth factor beta1 production; nucleolus; plasma membrane; positive regulation of protein localization to nucleus; regulation of actin cytoskeleton reorganization; ruffle IPR000108; IPR001452; CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1) Cd2ap Mets1 Mus musculus (Mouse) TR30118_c1_g1_i6 Q9JLQ0 CD2AP_MOUSE 5.00E-26 GO:0005938; GO:0051301; GO:0005829; GO:0031941; GO:0007067; GO:0032911; GO:0005730; GO:0005886; GO:1900182; GO:2000249; GO:0001726 cell cortex; cell division; cytosol; filamentous actin; mitosis; negative regulation of transforming growth factor beta1 production; nucleolus; plasma membrane; positive regulation of protein localization to nucleus; regulation of actin cytoskeleton reorganization; ruffle IPR000108; IPR001452; CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1) Cd2ap Mets1 Mus musculus (Mouse) TR30120_c0_g1_i1 P40792 RAC1_DROME 1.00E-68 GO:0005525; GO:0003924; GO:0007254; GO:0051017; GO:0034334; GO:0048675; GO:0007413; GO:0007298; GO:0035212; GO:0030866; GO:0005829; GO:0048813; GO:0071907; GO:0046843; GO:0046664; GO:0007394; GO:0048615; GO:0042067; GO:0019897; GO:0007390; GO:0008347; GO:0008258; GO:0007516; GO:0035099; GO:0035320; GO:0002433; GO:0030032; GO:0035011; GO:0008078; GO:0007017; GO:0016335; GO:0008045; GO:0048747; GO:0007520; GO:0051450; GO:0010593; GO:0007422; GO:0051491; GO:0071902; GO:0050770; GO:0051726; GO:0048814; GO:0045610; GO:0051963; GO:0006974; GO:0016028; GO:0042052; GO:0007435; GO:0050975; GO:0007264; GO:0007426; GO:0007419 P25843; Q24213 "GTP binding; GTPase activity; JNK cascade; actin filament bundle assembly; adherens junction maintenance; axon extension; axonal fasciculation; border follicle cell migration; cell competition in a multicellular organism; cortical actin cytoskeleton organization; cytosol; dendrite morphogenesis; determination of digestive tract left/right asymmetry; dorsal appendage formation; dorsal closure, amnioserosa morphology change; dorsal closure, elongation of leading edge cells; embryonic anterior midgut (ectodermal) morphogenesis; establishment of ommatidial planar polarity; extrinsic to plasma membrane; germ-band shortening; glial cell migration; head involution; hemocyte development; hemocyte migration; imaginal disc-derived wing hair site selection; immune response-regulating cell surface receptor signaling pathway involved in phagocytosis; lamellipodium assembly; melanotic encapsulation of foreign target; mesodermal cell migration; microtubule-based process; morphogenesis of larval imaginal disc epithelium; motor neuron axon guidance; muscle fiber development; myoblast fusion; myoblast proliferation; negative regulation of lamellipodium assembly; peripheral nervous system development; positive regulation of filopodium assembly; positive regulation of protein serine/threonine kinase activity; regulation of axonogenesis; regulation of cell cycle; regulation of dendrite morphogenesis; regulation of hemocyte differentiation; regulation of synapse assembly; response to DNA damage stimulus; rhabdomere; rhabdomere development; salivary gland morphogenesis; sensory perception of touch; small GTPase mediated signal transduction; tracheal outgrowth, open tracheal system; ventral cord development" IPR027417; IPR005225; IPR001806; IPR003578; Ras-related protein Rac1 Rac1 RacA CG2248 Drosophila melanogaster (Fruit fly) TR30120_c0_g1_i2 P53879 RHO5_YEAST 5.00E-27 GO:0005525; GO:0003924; GO:0007266; GO:0012505; GO:0000329; GO:0005886 GTP binding; GTPase activity; Rho protein signal transduction; endomembrane system; fungal-type vacuole membrane; plasma membrane IPR027417; IPR005225; IPR001806; IPR003578; GTP-binding protein RHO5 RHO5 YNL180C N1644 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR30122_c0_g3_i1 Q6R5N8 TLR13_MOUSE 5.00E-18 GO:0002755; GO:0005768; GO:0010008; GO:0006954; GO:0045087; GO:0016021; GO:0042803; GO:0019843; GO:0043408; GO:0002237; GO:0009615; GO:0034178; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; endosome; endosome membrane; inflammatory response; innate immune response; integral to membrane; protein homodimerization activity; rRNA binding; regulation of MAPK cascade; response to molecule of bacterial origin; response to virus; toll-like receptor 13 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR003591; IPR000157; IPR027196; Toll-like receptor 13 Tlr13 Mus musculus (Mouse) TR30122_c0_g3_i2 P08953 TOLL_DROME 5.00E-20 GO:0033565; GO:0008063; GO:0019732; GO:0007155; GO:0019955; GO:0050830; GO:0005769; GO:0009897; GO:0007507; GO:0035172; GO:0030097; GO:0045087; GO:0016021; GO:0006963; GO:0006967; GO:0045610; GO:0007416; GO:0016201; GO:0004888; GO:0007352 Itself; Q7K105 ESCRT-0 complex; Toll signaling pathway; antifungal humoral response; cell adhesion; cytokine binding; defense response to Gram-positive bacterium; early endosome; external side of plasma membrane; heart development; hemocyte proliferation; hemopoiesis; innate immune response; integral to membrane; positive regulation of antibacterial peptide biosynthetic process; positive regulation of antifungal peptide biosynthetic process; regulation of hemocyte differentiation; synapse assembly; synaptic target inhibition; transmembrane signaling receptor activity; zygotic specification of dorsal/ventral axis IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) TR30125_c0_g1_i3 A4QNC6 F136A_XENTR 3.00E-36 GO:0005739 mitochondrion IPR008560; Protein FAM136A fam136a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30137_c3_g1_i1 Q8TDJ6 DMXL2_HUMAN 2.00E-64 GO:0017137; GO:0030054; GO:0008021; GO:0030672 Rab GTPase binding; cell junction; synaptic vesicle; synaptic vesicle membrane IPR022033; IPR015943; IPR001680; IPR017986; DmX-like protein 2 (Rabconnectin-3) DMXL2 KIAA0856 Homo sapiens (Human) TR30137_c3_g1_i2 Q9Y485 DMXL1_HUMAN 2.00E-66 IPR022033; IPR015943; IPR001680; IPR017986; DmX-like protein 1 (X-like 1 protein) DMXL1 XL1 Homo sapiens (Human) TR30139_c0_g1_i1 Q28IM6 HPCL1_XENTR 6.00E-26 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Hippocalcin-like protein 1 hpcal1 TNeu142p12.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30147_c1_g1_i1 Q9BWU0 NADAP_HUMAN 7.00E-06 GO:0005737; GO:0005634 Q13418 cytoplasm; nucleus IPR014720; IPR000253; IPR008984; Kanadaptin (Human lung cancer oncogene 3 protein) (HLC-3) (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein) SLC4A1AP HLC3 Homo sapiens (Human) TR30147_c1_g2_i1 Q9BWU0 NADAP_HUMAN 5.00E-110 GO:0005737; GO:0005634 Q13418 cytoplasm; nucleus IPR014720; IPR000253; IPR008984; Kanadaptin (Human lung cancer oncogene 3 protein) (HLC-3) (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein) SLC4A1AP HLC3 Homo sapiens (Human) TR30147_c1_g2_i3 Q8W4D8 DDL_ARATH 4.00E-14 GO:0003723; GO:0008283; GO:0009507; GO:0005829; GO:0005634; GO:0035196; GO:0048638 Q9SP32 RNA binding; cell proliferation; chloroplast; cytosol; nucleus; production of miRNAs involved in gene silencing by miRNA; regulation of developmental growth IPR000253; IPR008984; FHA domain-containing protein DDL (Protein DAWDLE) DDL At3g20550 K10D20.9 Arabidopsis thaliana (Mouse-ear cress) TR30148_c0_g1_i2 Q9VZS3 SUI1_DROME 3.00E-46 GO:0071456; GO:0006417; GO:0003743 cellular response to hypoxia; regulation of translation; translation initiation factor activity IPR005874; IPR001950; Protein translation factor SUI1 homolog CG17737 Drosophila melanogaster (Fruit fly) TR30150_c0_g1_i4 P40986 CDC1_YEAST 2.00E-09 GO:0006281; GO:0030036; GO:0007049; GO:0051301; GO:0030026; GO:0016311; GO:0005783; GO:0016787; GO:0016021; GO:0046872 P43603 DNA repair; actin cytoskeleton organization; cell cycle; cell division; cellular manganese ion homeostasis; dephosphorylation; endoplasmic reticulum; hydrolase activity; integral to membrane; metal ion binding IPR004843; Cell division control protein 1 (EC 3.1.-.-) CDC1 DSR1 ESP2 YDR182W YD9395.16 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR30151_c0_g5_i1 Q71FD5 ZNRF2_MOUSE 2.00E-41 GO:0030054; GO:0010008; GO:0016874; GO:0005765; GO:0042734; GO:0016567; GO:0008270 cell junction; endosome membrane; ligase activity; lysosomal membrane; presynaptic membrane; protein ubiquitination; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase ZNRF2 (EC 6.3.2.-) (Zinc/RING finger protein 2) Znrf2 Mus musculus (Mouse) TR30154_c0_g1_i1 P38166 SFT2_YEAST 4.00E-21 GO:0000139; GO:0006895; GO:0016021; GO:0015031 Itself; P25376; P39010; P11076; P46989; P54858; P43555; P43561; P38310; P19145; Q03554; P09620; P40527; P32854; P38929; P40975; P87284; Q12270; P43621; P53600; Q06208; Q03860; P38142; P25361; P38800; Q03730 Golgi membrane; Golgi to endosome transport; integral to membrane; protein transport IPR007305; IPR011691; Protein transport protein SFT2 SFT2 YBL102W YBL0812 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR30155_c0_g2_i2 Q6DK99 CNFNB_XENLA 1.00E-08 IPR006461; Cornifelin homolog B cnfn-b Xenopus laevis (African clawed frog) TR30155_c0_g2_i3 D9HP19 CNR3_MAIZE 6.00E-13 GO:0016021 integral to membrane IPR006461; Cell number regulator 3 (ZmCNR03) CNR3 Zea mays (Maize) TR30155_c0_g2_i4 D9HP19 CNR3_MAIZE 5.00E-13 GO:0016021 integral to membrane IPR006461; Cell number regulator 3 (ZmCNR03) CNR3 Zea mays (Maize) TR30156_c0_g1_i1 Q9JJK3 PEX3_CRILO 1.00E-110 GO:0005779; GO:0045046 integral to peroxisomal membrane; protein import into peroxisome membrane IPR006966; Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3) PEX3 Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster) TR30159_c0_g1_i2 P13010 XRCC5_HUMAN 9.00E-34 GO:0005524; GO:0004003; GO:0006310; GO:0043564; GO:0008283; GO:0005829; GO:0003684; GO:0006303; GO:0003690; GO:0075713; GO:0060218; GO:0045087; GO:0043066; GO:0045892; GO:0070419; GO:0000783; GO:0005654; GO:0050769; GO:0032481; GO:0000723; GO:0042162; GO:0044212; GO:0006351 Q8IW19; P38432; P09629; P78527; P12956 "ATP binding; ATP-dependent DNA helicase activity; DNA recombination; Ku70:Ku80 complex; cell proliferation; cytosol; damaged DNA binding; double-strand break repair via nonhomologous end joining; double-stranded DNA binding; establishment of integrated proviral latency; hematopoietic stem cell differentiation; innate immune response; negative regulation of apoptotic process; negative regulation of transcription, DNA-dependent; nonhomologous end joining complex; nuclear telomere cap complex; nucleoplasm; positive regulation of neurogenesis; positive regulation of type I interferon production; telomere maintenance; telomeric DNA binding; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR006164; IPR024193; IPR005160; IPR005161; IPR014893; IPR016194; IPR002035; X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) XRCC5 G22P2 Homo sapiens (Human) TR30159_c0_g1_i5 P27641 XRCC5_MOUSE 2.00E-36 GO:0051575; GO:0005524; GO:0004003; GO:0006310; GO:0043564; GO:0008283; GO:0005737; GO:0003684; GO:0006303; GO:0003691; GO:0060218; GO:0045892; GO:0070419; GO:0000784; GO:0005730; GO:0050769; GO:0000723; GO:0044212; GO:0006351 "5'-deoxyribose-5-phosphate lyase activity; ATP binding; ATP-dependent DNA helicase activity; DNA recombination; Ku70:Ku80 complex; cell proliferation; cytoplasm; damaged DNA binding; double-strand break repair via nonhomologous end joining; double-stranded telomeric DNA binding; hematopoietic stem cell differentiation; negative regulation of transcription, DNA-dependent; nonhomologous end joining complex; nuclear chromosome, telomeric region; nucleolus; positive regulation of neurogenesis; telomere maintenance; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR006164; IPR024193; IPR005160; IPR005161; IPR014893; IPR016194; IPR002035; X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku autoantigen protein p86 homolog) (Ku80) (Nuclear factor IV) Xrcc5 G22p2 Mus musculus (Mouse) TR30161_c5_g4_i1 Q3BAI2 YCX91_PHAAO 1.00E-21 GO:0009507 chloroplast Uncharacterized protein ORF91 Phalaenopsis aphrodite subsp. formosana (Moth orchid) TR30162_c0_g1_i2 Q9H6T3 RPAP3_HUMAN 1.00E-54 Q96MX6 IPR025986; IPR013026; IPR011990; IPR001440; IPR019734; RNA polymerase II-associated protein 3 RPAP3 Homo sapiens (Human) TR30162_c0_g1_i3 Q9H6T3 RPAP3_HUMAN 3.00E-54 Q96MX6 IPR025986; IPR013026; IPR011990; IPR001440; IPR019734; RNA polymerase II-associated protein 3 RPAP3 Homo sapiens (Human) TR30164_c1_g1_i3 Q95K79 ALKB8_MACFA 9.00E-122 GO:0003723; GO:0005829; GO:0046872; GO:0000166; GO:0005634; GO:0016706; GO:0006974; GO:0016300 "RNA binding; cytosol; metal ion binding; nucleotide binding; nucleus; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; response to DNA damage stimulus; tRNA (uracil) methyltransferase activity" IPR027450; IPR015095; IPR013216; IPR012677; IPR005123; Alkylated DNA repair protein alkB homolog 8 (EC 1.14.11.-) (Probable alpha-ketoglutarate-dependent dioxygenase ABH8) (S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8) (tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8) (EC 2.1.1.-) (EC 2.1.1.229) ALKBH8 QtrA-10552 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR30168_c0_g1_i1 Q8WTR2 DUS19_HUMAN 2.00E-54 GO:0007254; GO:0008579; GO:0005078; GO:0005737; GO:0000188; GO:0031435; GO:0046329; GO:0043508; GO:0035335; GO:0046330; GO:0043507; GO:0030295; GO:0004860; GO:0004725; GO:0008330 JNK cascade; JUN kinase phosphatase activity; MAP-kinase scaffold activity; cytoplasm; inactivation of MAPK activity; mitogen-activated protein kinase kinase kinase binding; negative regulation of JNK cascade; negative regulation of JUN kinase activity; peptidyl-tyrosine dephosphorylation; positive regulation of JNK cascade; positive regulation of JUN kinase activity; protein kinase activator activity; protein kinase inhibitor activity; protein tyrosine phosphatase activity; protein tyrosine/threonine phosphatase activity IPR020417; IPR000340; IPR020422; IPR024950; IPR000387; Dual specificity protein phosphatase 19 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase TS-DSP1) (Low molecular weight dual specificity phosphatase 3) (LMW-DSP3) (Protein phosphatase SKRP1) (Stress-activated protein kinase pathway-regulating phosphatase 1) (SAPK pathway-regulating phosphatase 1) DUSP19 DUSP17 LMWDSP3 SKRP1 Homo sapiens (Human) TR30170_c1_g1_i3 Q11131 FUT7_MOUSE 3.00E-36 GO:0002361; GO:0032580; GO:0036065; GO:0008417; GO:0016021; GO:0002522; GO:0006486 "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; Golgi cisterna membrane; fucosylation; fucosyltransferase activity; integral to membrane; leukocyte migration involved in immune response; protein glycosylation" IPR001503; Protein modification; protein glycosylation. "Alpha-(1,3)-fucosyltransferase 7 (EC 2.4.1.-) (Fucosyltransferase 7) (Fucosyltransferase VII) (Fuc-TVII) (FucT-VII) (Galactoside 3-L-fucosyltransferase)" Fut7 Mus musculus (Mouse) TR30171_c0_g1_i1 P35440 TSP2_CHICK 4.00E-22 GO:0005604; GO:0005509; GO:0007155; GO:0008201; GO:0016525 basement membrane; calcium ion binding; cell adhesion; heparin binding; negative regulation of angiogenesis IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR024731; IPR001791; IPR000884; IPR015455; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-2 THBS2 TSP2 Gallus gallus (Chicken) TR30171_c0_g1_i2 P11680 PROP_MOUSE 7.00E-18 GO:0006957; GO:0031012; GO:0005576 "complement activation, alternative pathway; extracellular matrix; extracellular region" IPR000884; Properdin (Complement factor P) Cfp Pfc Mus musculus (Mouse) TR30171_c0_g1_i3 P57110 ATS8_MOUSE 1.00E-08 GO:0008201; GO:0004222; GO:0005578; GO:0006508; GO:0008270 heparin binding; metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR013277; IPR001590; IPR013273; IPR002870; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAM-TS 8) (ADAM-TS8) (ADAMTS-8) (EC 3.4.24.-) (METH-2) Adamts8 Mus musculus (Mouse) TR30171_c0_g1_i4 P35440 TSP2_CHICK 2.00E-26 GO:0005604; GO:0005509; GO:0007155; GO:0008201; GO:0016525 basement membrane; calcium ion binding; cell adhesion; heparin binding; negative regulation of angiogenesis IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR024731; IPR001791; IPR000884; IPR015455; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-2 THBS2 TSP2 Gallus gallus (Chicken) TR30171_c0_g1_i5 Q700K0 SSPO_RAT 8.00E-09 GO:0007155; GO:0005615 cell adhesion; extracellular space IPR000421; IPR006207; IPR008979; IPR023415; IPR002172; IPR000884; IPR002919; IPR014853; IPR006552; IPR001007; IPR001846; SCO-spondin Sspo Rattus norvegicus (Rat) TR30172_c0_g2_i1 P63081 VATL_RAT 2.00E-52 GO:0015991; GO:0042625; GO:0005794; GO:0015078; GO:0016021; GO:0005764; GO:0033179; GO:0005774 "ATP hydrolysis coupled proton transport; ATPase activity, coupled to transmembrane movement of ions; Golgi apparatus; hydrogen ion transmembrane transporter activity; integral to membrane; lysosome; proton-transporting V-type ATPase, V0 domain; vacuolar membrane" IPR002379; IPR000245; IPR011555; V-type proton ATPase 16 kDa proteolipid subunit (V-ATPase 16 kDa proteolipid subunit) (Vacuolar proton pump 16 kDa proteolipid subunit) Atp6v0c Atp6c Atp6l Atpl Rattus norvegicus (Rat) TR30173_c0_g1_i1 D3Z8N4 KLH20_RAT 7.00E-35 GO:0031463; GO:0005794; GO:0016605; GO:0009986; GO:0005737; GO:0019964; GO:0043066; GO:0048471; GO:0043161; GO:0004842 Cul3-RING ubiquitin ligase complex; Golgi apparatus; PML body; cell surface; cytoplasm; interferon-gamma binding; negative regulation of apoptotic process; perinuclear region of cytoplasm; proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 20 Klhl20 Rattus norvegicus (Rat) TR30173_c0_g1_i2 Q6DFF6 KLH20_XENLA 9.00E-37 GO:0031463; GO:0016605; GO:0005737; GO:0019964; GO:0043066; GO:0048471; GO:0043161; GO:0004842 Cul3-RING ubiquitin ligase complex; PML body; cytoplasm; interferon-gamma binding; negative regulation of apoptotic process; perinuclear region of cytoplasm; proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 20 klhl20 Xenopus laevis (African clawed frog) TR30174_c4_g1_i1 Q9IBD8 PTPRC_CYPCA 4.00E-28 GO:0050852; GO:0016021; GO:0035335; GO:0004725 T cell receptor signaling pathway; integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR003961; IPR013783; IPR016335; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (CD antigen CD45) ptprc Cyprinus carpio (Common carp) TR30174_c4_g2_i1 P28828 PTPRM_MOUSE 7.00E-38 GO:0045296; GO:0005913; GO:0007156; GO:0016021; GO:0030027; GO:0016525; GO:0010596; GO:0001937; GO:0048471; GO:0045909; GO:0042493; GO:0010842; GO:0031290; GO:0005001 cadherin binding; cell-cell adherens junction; homophilic cell adhesion; integral to membrane; lamellipodium; negative regulation of angiogenesis; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; perinuclear region of cytoplasm; positive regulation of vasodilation; response to drug; retina layer formation; retinal ganglion cell axon guidance; transmembrane receptor protein tyrosine phosphatase activity IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR013151; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Ptprm Kiaa4044 Mus musculus (Mouse) TR30174_c4_g2_i2 Q15678 PTN14_HUMAN 1.00E-15 GO:0005737; GO:0005856; GO:0001946; GO:0008285; GO:0005634; GO:0004725; GO:0046825; GO:0006355; GO:0003712; GO:0006351 "cytoplasm; cytoskeleton; lymphangiogenesis; negative regulation of cell proliferation; nucleus; protein tyrosine phosphatase activity; regulation of protein export from nucleus; regulation of transcription, DNA-dependent; transcription cofactor activity; transcription, DNA-dependent" IPR019749; IPR019750; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; IPR000387; IPR016130; IPR014392; IPR000242; Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) PTPN14 PEZ PTPD2 Homo sapiens (Human) TR30174_c4_g4_i1 P28199 PTP7_STYPL 6.00E-14 GO:0035335; GO:0004725 peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR000242; Tyrosine-protein phosphatase 7 (EC 3.1.3.48) (Fragment) STY-7 Styela plicata (Sea squirt) (Ascidia plicata) TR30174_c5_g2_i2 P70289 PTPRV_MOUSE 3.00E-18 GO:0006977; GO:0044242; GO:0032869; GO:0042593; GO:0016021; GO:0008285; GO:0046676; GO:0031016; GO:0035335; GO:0018214; GO:0004725; GO:0044342 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; cellular lipid catabolic process; cellular response to insulin stimulus; glucose homeostasis; integral to membrane; negative regulation of cell proliferation; negative regulation of insulin secretion; pancreas development; peptidyl-tyrosine dephosphorylation; protein carboxylation; protein tyrosine phosphatase activity; type B pancreatic cell proliferation" IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase V (R-PTP-V) (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase) Ptprv Esp Mus musculus (Mouse) TR30177_c3_g1_i2 O89110 CASP8_MOUSE 2.00E-20 GO:0030690; GO:0006919; GO:0001525; GO:0071260; GO:0005813; GO:0097153; GO:0031264; GO:0008625; GO:0007507; GO:0097284; GO:0030225; GO:0005739; GO:0043124; GO:0060546; GO:0001841; GO:0043123; GO:2001238; GO:0045651; GO:0045862; GO:0051603; GO:0070243; GO:0034612 P10275; P19091; P25446; Q9D8Y7 Noc1p-Noc2p complex; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; death-inducing signaling complex; extrinsic apoptotic signaling pathway via death domain receptors; heart development; hepatocyte apoptotic process; macrophage differentiation; mitochondrion; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of necroptosis; neural tube formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of macrophage differentiation; positive regulation of proteolysis; proteolysis involved in cellular protein catabolic process; regulation of thymocyte apoptotic process; response to tumor necrosis factor IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] Casp8 Mus musculus (Mouse) TR30177_c3_g1_i3 P55214 CASP7_MESAU 2.00E-18 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR015471; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; "Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11; Caspase-7, N-terminally processed]" CASP7 MCH3 Mesocricetus auratus (Golden hamster) TR30177_c3_g1_i4 O89110 CASP8_MOUSE 2.00E-20 GO:0030690; GO:0006919; GO:0001525; GO:0071260; GO:0005813; GO:0097153; GO:0031264; GO:0008625; GO:0007507; GO:0097284; GO:0030225; GO:0005739; GO:0043124; GO:0060546; GO:0001841; GO:0043123; GO:2001238; GO:0045651; GO:0045862; GO:0051603; GO:0070243; GO:0034612 P10275; P19091; P25446; Q9D8Y7 Noc1p-Noc2p complex; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; death-inducing signaling complex; extrinsic apoptotic signaling pathway via death domain receptors; heart development; hepatocyte apoptotic process; macrophage differentiation; mitochondrion; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of necroptosis; neural tube formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of macrophage differentiation; positive regulation of proteolysis; proteolysis involved in cellular protein catabolic process; regulation of thymocyte apoptotic process; response to tumor necrosis factor IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] Casp8 Mus musculus (Mouse) TR30181_c0_g1_i2 Q6DRH5 NOP10_DANRE 3.00E-27 GO:0072588; GO:0005730; GO:0060215; GO:0001522; GO:0006364; GO:0030515 box H/ACA RNP complex; nucleolus; primitive hemopoiesis; pseudouridine synthesis; rRNA processing; snoRNA binding IPR007264; H/ACA ribonucleoprotein complex subunit 3 (Nucleolar protein 10) (Nucleolar protein family A member 3) (snoRNP protein NOP10) nop10 nola3 Danio rerio (Zebrafish) (Brachydanio rerio) TR30183_c1_g1_i1 Q9VMW8 MPU1_DROME 6.00E-21 GO:0016021; GO:0006810 Q9VK20 integral to membrane; transport IPR006603; IPR016817; Mannose-P-dolichol utilization defect 1 protein homolog CG3792 Drosophila melanogaster (Fruit fly) TR30185_c1_g1_i1 Q4V7Q6 ULK3_XENLA 5.00E-70 GO:0005524; GO:0006914; GO:0005737; GO:0045879; GO:0045880; GO:0046777; GO:0004674 ATP binding; autophagy; cytoplasm; negative regulation of smoothened signaling pathway; positive regulation of smoothened signaling pathway; protein autophosphorylation; protein serine/threonine kinase activity IPR011009; IPR007330; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) ulk3 Xenopus laevis (African clawed frog) TR30185_c3_g1_i1 O70405 ULK1_MOUSE 7.00E-30 GO:0005524; GO:0007265; GO:0070969; GO:0005776; GO:0000045; GO:0048675; GO:0021707; GO:0030659; GO:0005829; GO:0048671; GO:0043005; GO:0043025; GO:0010508; GO:0016239; GO:0034045; GO:0046777; GO:0008104; GO:0004674; GO:0021933; GO:0031623; GO:0051386 ATP binding; Ras protein signal transduction; ULK1-ATG13-FIP200 complex; autophagic vacuole; autophagic vacuole assembly; axon extension; cerebellar granule cell differentiation; cytoplasmic vesicle membrane; cytosol; negative regulation of collateral sprouting; neuron projection; neuronal cell body; positive regulation of autophagy; positive regulation of macroautophagy; pre-autophagosomal structure membrane; protein autophosphorylation; protein localization; protein serine/threonine kinase activity; radial glia guided migration of cerebellar granule cell; receptor internalization; regulation of neurotrophin TRK receptor signaling pathway IPR011009; IPR000719; IPR017441; IPR002290; IPR016237; IPR008271; IPR022708; Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Serine/threonine-protein kinase Unc51.1) (Unc-51-like kinase 1) Ulk1 Mus musculus (Mouse) TR30189_c2_g2_i1 Q4G0X9 CCD40_HUMAN 2.00E-45 GO:0070286; GO:0005929; GO:0005737; GO:0071907; GO:0071910; GO:0035469; GO:0060287; GO:0001947; GO:0030324; GO:0003356 axonemal dynein complex assembly; cilium; cytoplasm; determination of digestive tract left/right asymmetry; determination of liver left/right asymmetry; determination of pancreatic left/right asymmetry; epithelial cilium movement involved in determination of left/right asymmetry; heart looping; lung development; regulation of cilium beat frequency IPR013956; Coiled-coil domain-containing protein 40 CCDC40 KIAA1640 Homo sapiens (Human) TR30189_c3_g1_i1 Q8BI79 CCD40_MOUSE 2.00E-44 GO:0070286; GO:0005929; GO:0005737; GO:0071907; GO:0071910; GO:0035469; GO:0060287; GO:0001947; GO:0030324; GO:0003356 axonemal dynein complex assembly; cilium; cytoplasm; determination of digestive tract left/right asymmetry; determination of liver left/right asymmetry; determination of pancreatic left/right asymmetry; epithelial cilium movement involved in determination of left/right asymmetry; heart looping; lung development; regulation of cilium beat frequency IPR013956; Coiled-coil domain-containing protein 40 (Protein links) Ccdc40 Lnks Mus musculus (Mouse) TR30189_c5_g2_i2 Q4G0X9 CCD40_HUMAN 3.00E-69 GO:0070286; GO:0005929; GO:0005737; GO:0071907; GO:0071910; GO:0035469; GO:0060287; GO:0001947; GO:0030324; GO:0003356 axonemal dynein complex assembly; cilium; cytoplasm; determination of digestive tract left/right asymmetry; determination of liver left/right asymmetry; determination of pancreatic left/right asymmetry; epithelial cilium movement involved in determination of left/right asymmetry; heart looping; lung development; regulation of cilium beat frequency IPR013956; Coiled-coil domain-containing protein 40 CCDC40 KIAA1640 Homo sapiens (Human) TR30190_c8_g1_i1 Q7Z3K3 POGZ_HUMAN 2.00E-08 GO:0003677; GO:0051301; GO:0005737; GO:0051382; GO:0046872; GO:0007064; GO:0000790 P45973; P08047 DNA binding; cell division; cytoplasm; kinetochore assembly; metal ion binding; mitotic sister chromatid cohesion; nuclear chromatin IPR004875; IPR009057; IPR006600; IPR007087; IPR015880; Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) POGZ KIAA0461 SUHW5 ZNF280E ZNF635 Nbla00003 Homo sapiens (Human) TR30190_c8_g1_i6 Q8BZH4 POGZ_MOUSE 4.00E-06 GO:0003677; GO:0051301; GO:0005737; GO:0051382; GO:0046872; GO:0007064; GO:0000790 DNA binding; cell division; cytoplasm; kinetochore assembly; metal ion binding; mitotic sister chromatid cohesion; nuclear chromatin IPR004875; IPR009057; IPR006600; IPR007087; IPR015880; Pogo transposable element with ZNF domain Pogz Kiaa0461 Mus musculus (Mouse) TR30191_c1_g1_i1 P07314 GGT1_RAT 1.00E-166 GO:0007568; GO:0034599; GO:0005615; GO:0003840; GO:0006536; GO:0006750; GO:0006751; GO:0036374; GO:0005887; GO:0031179; GO:0032355; GO:0032496; GO:0034612 aging; cellular response to oxidative stress; extracellular space; gamma-glutamyltransferase activity; glutamate metabolic process; glutathione biosynthetic process; glutathione catabolic process; glutathione hydrolase activity; integral to plasma membrane; peptide modification; response to estradiol stimulus; response to lipopolysaccharide; response to tumor necrosis factor IPR000101; Sulfur metabolism; glutathione metabolism. Gamma-glutamyltranspeptidase 1 (GGT 1) (EC 2.3.2.2) (Gamma-glutamyltransferase 1) (Glutathione hydrolase 1) (EC 3.4.19.13) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Gamma-glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain] Ggt1 Ggt Rattus norvegicus (Rat) TR30192_c1_g1_i1 O35536 TFPI2_MOUSE 2.00E-23 GO:0007596; GO:0005576; GO:0004867 blood coagulation; extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR008296; IPR020901; Tissue factor pathway inhibitor 2 (TFPI-2) Tfpi2 Mus musculus (Mouse) TR30192_c1_g1_i2 P48307 TFPI2_HUMAN 2.00E-14 GO:0007596; GO:0005201; GO:0005578; GO:0004867 blood coagulation; extracellular matrix structural constituent; proteinaceous extracellular matrix; serine-type endopeptidase inhibitor activity IPR002223; IPR008296; IPR020901; Tissue factor pathway inhibitor 2 (TFPI-2) (Placental protein 5) (PP5) TFPI2 Homo sapiens (Human) TR30196_c0_g1_i1 Q9BSF4 CS052_HUMAN 9.00E-24 IPR019322; Uncharacterized protein C19orf52 C19orf52 Homo sapiens (Human) TR30197_c0_g1_i3 A8Y1P7 BRE4_CAEBR 7.00E-58 GO:0016021; GO:0046872; GO:0006486; GO:0016757 "integral to membrane; metal ion binding; protein glycosylation; transferase activity, transferring glycosyl groups" IPR003859; IPR027791; IPR027995; Protein modification; protein glycosylation. "Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.-) (Bacillus thuringiensis toxin-resistant protein 4) (Bt toxin-resistant protein 4) (Beta-4-GalNAcT)" bre-4 CBG22165 Caenorhabditis briggsae TR30198_c4_g1_i1 Q7SY73 ABH6B_XENLA 2.00E-17 GO:0047372; GO:0016021 acylglycerol lipase activity; integral to membrane IPR000073; Monoacylglycerol lipase abhd6-B (EC 3.1.1.23) (Abhydrolase domain-containing protein 6-B) abhd6-b Xenopus laevis (African clawed frog) TR30200_c0_g1_i2 A6BM06 ACCO1_DICMU 1.00E-11 GO:0009815; GO:0009693; GO:0005506; GO:0016706 "1-aminocyclopropane-1-carboxylate oxidase activity; ethylene biosynthetic process; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" IPR026992; IPR027443; IPR002283; IPR005123; Alkene biosynthesis; ethylene biosynthesis via S-adenosyl-L-methionine; ethylene from S-adenosyl-L-methionine: step 2/2. 1-aminocyclopropane-1-carboxylate oxidase (ACC oxidase) (Dmaco) (EC 1.14.17.4) (Ethylene-forming enzyme) (EFE) aco Dictyostelium mucoroides (Slime mold) TR30200_c0_g1_i6 Q7LL04 YQK1_SCHPO 5.00E-28 GO:0005829; GO:0005634; GO:0016706 "cytosol; nucleus; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" IPR026992; IPR027443; IPR005123; UPF0676 protein C1494.01 SPCC1494.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR30201_c0_g1_i1 Q3SZ21 RPP30_BOVIN 8.00E-64 GO:0005730; GO:0004526; GO:0008033 nucleolus; ribonuclease P activity; tRNA processing IPR016195; IPR002738; Ribonuclease P protein subunit p30 (RNaseP protein p30) (EC 3.1.26.5) (RNase P subunit 2) RPP30 RNASEP2 Bos taurus (Bovine) TR30201_c0_g1_i2 Q3SZ21 RPP30_BOVIN 4.00E-64 GO:0005730; GO:0004526; GO:0008033 nucleolus; ribonuclease P activity; tRNA processing IPR016195; IPR002738; Ribonuclease P protein subunit p30 (RNaseP protein p30) (EC 3.1.26.5) (RNase P subunit 2) RPP30 RNASEP2 Bos taurus (Bovine) TR30202_c0_g2_i4 P83425 HIP_MYTED 3.00E-09 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR30202_c0_g2_i5 Q8IUK8 CBLN2_HUMAN 3.00E-06 GO:0005615; GO:0051965 extracellular space; positive regulation of synapse assembly IPR001073; IPR008983; Cerebellin-2 CBLN2 UNQ1892/PRO4338 Homo sapiens (Human) TR30202_c0_g2_i6 P63182 CBLN1_RAT 1.00E-06 GO:0030054; GO:0005576; GO:0051965; GO:0045211; GO:0009306 cell junction; extracellular region; positive regulation of synapse assembly; postsynaptic membrane; protein secretion IPR001073; IPR008983; Cerebellin-1 (Precerebellin) [Cleaved into: Cerebellin (CER); [des-Ser1]-cerebellin (des-Ser(1)-cerebellin) ([des-Ser1]CER) (des-CER) (des-Ser1CER)] Cbln1 Rattus norvegicus (Rat) TR30203_c1_g1_i1 Q8R4Y8 RTTN_MOUSE 2.00E-21 GO:0036064; GO:0005737; GO:0007368; GO:0016021 cilium basal body; cytoplasm; determination of left/right symmetry; integral to membrane IPR011989; IPR016024; Rotatin Rttn Mus musculus (Mouse) TR30203_c8_g1_i1 Q8R4Y8 RTTN_MOUSE 4.00E-21 GO:0036064; GO:0005737; GO:0007368; GO:0016021 cilium basal body; cytoplasm; determination of left/right symmetry; integral to membrane IPR011989; IPR016024; Rotatin Rttn Mus musculus (Mouse) TR30206_c0_g1_i1 P62755 RS6_RAT 1.00E-116 GO:0031929; GO:0022627; GO:0042593; GO:0005730; GO:0043065; GO:0006364; GO:0000028; GO:0003735; GO:0006412 TOR signaling cascade; cytosolic small ribosomal subunit; glucose homeostasis; nucleolus; positive regulation of apoptotic process; rRNA processing; ribosomal small subunit assembly; structural constituent of ribosome; translation IPR014401; IPR001377; IPR018282; 40S ribosomal protein S6 Rps6 Rattus norvegicus (Rat) TR30211_c0_g1_i2 P14393 GLB_APLJU 4.00E-19 GO:0005576; GO:0020037; GO:0005833; GO:0005506; GO:0019825; GO:0005344 extracellular region; heme binding; hemoglobin complex; iron ion binding; oxygen binding; oxygen transporter activity IPR002336; IPR000971; IPR009050; IPR012292; Globin (Myoglobin) Aplysia juliana (Walking sea hare) (Juliana's sea hare) TR30211_c0_g1_i4 P29287 GLB_BURLE 3.00E-11 GO:0005576; GO:0020037; GO:0005833; GO:0005506; GO:0019825; GO:0005344 extracellular region; heme binding; hemoglobin complex; iron ion binding; oxygen binding; oxygen transporter activity IPR002336; IPR000971; IPR009050; IPR012292; Globin (Myoglobin) Bursatella leachii (Ragged sea hare) TR30212_c1_g1_i4 Q9VNL4 GRCR1_DROME 5.00E-57 GO:0045454; GO:0009055; GO:0015035 Q9I7J2 cell redox homeostasis; electron carrier activity; protein disulfide oxidoreductase activity IPR002109; IPR012336; Glutaredoxin domain-containing cysteine-rich protein CG31559 CG31559 Drosophila melanogaster (Fruit fly) TR30212_c1_g1_i5 Q9W4S1 GRCR2_DROME 5.00E-56 GO:0045454; GO:0009055; GO:0015035 cell redox homeostasis; electron carrier activity; protein disulfide oxidoreductase activity IPR002109; IPR012336; Glutaredoxin domain-containing cysteine-rich protein CG12206 CG12206 Drosophila melanogaster (Fruit fly) TR30212_c1_g1_i6 Q3TYR5 GRCR2_MOUSE 1.00E-12 IPR001305; Glutaredoxin domain-containing cysteine-rich protein 2 (GRXCR1-like protein) (Glutaredoxin domain-containing cysteine-rich protein 1-like protein) Grxcr2 Gm851 Mus musculus (Mouse) TR30215_c0_g2_i1 P19477 FIBA_PARPA 6.00E-28 IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein A (FREP-A) Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) TR30215_c0_g2_i2 E2IYB3 FCNV1_VARKO 2.00E-06 GO:0005576 extracellular region IPR008160; IPR014716; IPR002181; Veficolin-1 (Fragment) Varanus komodoensis (Komodo dragon) TR30217_c0_g1_i1 Q61466 SMRD1_MOUSE 0 GO:0016514; GO:0048096; GO:0071565; GO:0007399; GO:0071564; GO:0006337 P02340 SWI/SNF complex; chromatin-mediated maintenance of transcription; nBAF complex; nervous system development; npBAF complex; nucleosome disassembly IPR019835; IPR003121; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (60 kDa BRG-1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A) (Protein D15KZ1) (SWI/SNF complex 60 kDa subunit) Smarcd1 Baf60a D15Kz1 Mus musculus (Mouse) TR30217_c0_g1_i2 Q61466 SMRD1_MOUSE 0 GO:0016514; GO:0048096; GO:0071565; GO:0007399; GO:0071564; GO:0006337 P02340 SWI/SNF complex; chromatin-mediated maintenance of transcription; nBAF complex; nervous system development; npBAF complex; nucleosome disassembly IPR019835; IPR003121; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (60 kDa BRG-1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A) (Protein D15KZ1) (SWI/SNF complex 60 kDa subunit) Smarcd1 Baf60a D15Kz1 Mus musculus (Mouse) TR30217_c0_g1_i3 Q556Z0 SNF12_DICDI 3.00E-53 GO:0016568; GO:0005654; GO:0006355; GO:0006351 "chromatin modification; nucleoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003121; SWI/SNF complex component SNF12 homolog snf12-1 DDB_G0273203; snf12-2 DDB_G0273725 Dictyostelium discoideum (Slime mold) TR30217_c0_g1_i5 O74503 UAF30_SCHPO 3.00E-09 GO:0003677; GO:0000500; GO:0005829; GO:0045943; GO:0006351 "DNA binding; RNA polymerase I upstream activating factor complex; cytosol; positive regulation of transcription from RNA polymerase I promoter; transcription, DNA-dependent" IPR014876; IPR009057; IPR019835; IPR003121; Upstream activation factor subunit spp27 (Upstream activation factor 27 KDa subunit) (p27) (Upstream activation factor 30 KDa subunit) (p30) (Upstream activation factor subunit uaf30) spp27 uaf30 SPCC285.17 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR30218_c2_g1_i1 Q6AYP4 ZC21C_RAT 1.00E-12 GO:0046872 metal ion binding IPR026104; Zinc finger C2HC domain-containing protein 1C Zc2hc1c Fam164c Rattus norvegicus (Rat) TR30221_c0_g1_i2 Q15125 EBP_HUMAN 9.00E-67 GO:0000247; GO:0047750; GO:0006695; GO:0015238; GO:0005789; GO:0030097; GO:0005887; GO:0001501; GO:0004769; GO:0004888 C-8 sterol isomerase activity; cholestenol delta-isomerase activity; cholesterol biosynthetic process; drug transmembrane transporter activity; endoplasmic reticulum membrane; hemopoiesis; integral to plasma membrane; skeletal system development; steroid delta-isomerase activity; transmembrane signaling receptor activity IPR007905; Steroid biosynthesis; cholesterol biosynthesis. "3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Delta(8)-Delta(7) sterol isomerase) (D8-D7 sterol isomerase) (Emopamil-binding protein)" EBP Homo sapiens (Human) TR30221_c0_g1_i3 Q9JJ46 EBP_RAT 2.00E-69 GO:0000247; GO:0047750; GO:0006695; GO:0005789; GO:0016021; GO:0043231 C-8 sterol isomerase activity; cholestenol delta-isomerase activity; cholesterol biosynthetic process; endoplasmic reticulum membrane; integral to membrane; intracellular membrane-bounded organelle IPR007905; Steroid biosynthesis; cholesterol biosynthesis. "3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Delta(8)-Delta(7) sterol isomerase) (D8-D7 sterol isomerase) (Emopamil-binding protein) (Sterol 8-isomerase)" Ebp Rsi Rattus norvegicus (Rat) TR30221_c0_g1_i4 Q9D0P0 EBPL_MOUSE 8.00E-19 GO:0047750; GO:0005789; GO:0016021; GO:0016125 cholestenol delta-isomerase activity; endoplasmic reticulum membrane; integral to membrane; sterol metabolic process IPR007905; Emopamil-binding protein-like (Emopamil-binding-related protein) Ebpl Ebrp Erp Mus musculus (Mouse) TR30225_c2_g1_i1 Q8N539 FBCD1_HUMAN 9.00E-35 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 UNQ701/PRO1346 Homo sapiens (Human) TR30225_c2_g1_i2 Q15485 FCN2_HUMAN 8.00E-36 GO:0003823; GO:0005509; GO:0030246; GO:0005581; GO:0001867; GO:0005576; GO:0008228 Q07954 "antigen binding; calcium ion binding; carbohydrate binding; collagen; complement activation, lectin pathway; extracellular region; opsonization" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-2 (37 kDa elastin-binding protein) (Collagen/fibrinogen domain-containing protein 2) (EBP-37) (Ficolin-B) (Ficolin-beta) (Hucolin) (L-ficolin) (Serum lectin p35) FCN2 FCNL Homo sapiens (Human) TR30225_c2_g1_i4 P12804 FGL2_MOUSE 3.00E-24 GO:0019835; GO:0005576 cytolysis; extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Fibroleukin (Cytotoxic T-lymphocyte-specific protein) (Fibrinogen-like protein 2) (Prothrombinase) Fgl2 Fiblp Mus musculus (Mouse) TR30226_c0_g1_i1 P43610 IRC5_YEAST 2.00E-09 GO:0005524; GO:0003677; GO:0004386; GO:0006312; GO:0005634 ATP binding; DNA binding; helicase activity; mitotic recombination; nucleus IPR014001; IPR001650; IPR027417; IPR000330; Uncharacterized ATP-dependent helicase IRC5 (EC 3.6.4.-) (Increased recombination centers protein 5) IRC5 YFR038W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR30226_c0_g2_i1 O60264 SMCA5_HUMAN 3.00E-27 GO:0005524; GO:0016887; GO:0034080; GO:0003677; GO:0006352; GO:0016589; GO:0031213; GO:0003682; GO:0000183; GO:0005677; GO:0000793; GO:0006302; GO:0009790; GO:0004386; GO:0005730; GO:0005654; GO:0016584; GO:0045893; GO:0006357 Q9UIG0; P62805; Q96T23 "ATP binding; ATPase activity; CENP-A containing nucleosome assembly at centromere; DNA binding; DNA-dependent transcription, initiation; NURF complex; RSF complex; chromatin binding; chromatin silencing at rDNA; chromatin silencing complex; condensed chromosome; double-strand break repair; embryo development; helicase activity; nucleolus; nucleoplasm; nucleosome positioning; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter" IPR020838; IPR014001; IPR001650; IPR009057; IPR015194; IPR027417; IPR001005; IPR017884; IPR015195; IPR000330; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) SMARCA5 SNF2H WCRF135 Homo sapiens (Human) TR30227_c0_g1_i3 Q5ZID0 NMRL1_CHICK 2.00E-67 GO:0005730; GO:0048471 nucleolus; perinuclear region of cytoplasm IPR016040; IPR008030; NmrA-like family domain-containing protein 1 NMRAL1 RCJMB04_27o15 Gallus gallus (Chicken) TR30228_c1_g1_i1 Q3TLD5 RMP_MOUSE 1.00E-31 GO:0005665; GO:0001106; GO:0071363; GO:0071383; GO:0003682; GO:0005737; GO:0030425; GO:0005739; GO:2001243; GO:0010923; GO:0005634; GO:0016272; GO:0006457; GO:0004864; GO:0001558; GO:0009615 "DNA-directed RNA polymerase II, core complex; RNA polymerase II transcription corepressor activity; cellular response to growth factor stimulus; cellular response to steroid hormone stimulus; chromatin binding; cytoplasm; dendrite; mitochondrion; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of phosphatase activity; nucleus; prefoldin complex; protein folding; protein phosphatase inhibitor activity; regulation of cell growth; response to virus" IPR009053; IPR004127; Unconventional prefoldin RPB5 interactor (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein) Uri1 Nnx3 Ppp1r19 Rmp Uri Mus musculus (Mouse) TR30230_c1_g1_i1 Q9CPY6 GID4_MOUSE 1.00E-122 IPR018618; Glucose-induced degradation protein 4 homolog (Vacuolar import and degradation protein 24 homolog) Gid4 Mus musculus (Mouse) TR30232_c0_g2_i1 Q3V1H9 SAMD5_MOUSE 3.00E-25 IPR001660; IPR013761; IPR021129; Sterile alpha motif domain-containing protein 5 (SAM domain-containing protein 5) Samd5 Mus musculus (Mouse) TR30232_c1_g1_i1 A0JN71 SASH3_BOVIN 4.00E-18 GO:0005737; GO:0048873; GO:0005634; GO:0030890; GO:0043372; GO:0002726; GO:0042102; GO:0002639; GO:0032729; GO:0032733; GO:0032743; GO:0032753; GO:0046622; GO:0032760 "cytoplasm; homeostasis of number of cells within a tissue; nucleus; positive regulation of B cell proliferation; positive regulation of CD4-positive, alpha-beta T cell differentiation; positive regulation of T cell cytokine production; positive regulation of T cell proliferation; positive regulation of immunoglobulin production; positive regulation of interferon-gamma production; positive regulation of interleukin-10 production; positive regulation of interleukin-2 production; positive regulation of interleukin-4 production; positive regulation of organ growth; positive regulation of tumor necrosis factor production" IPR021090; IPR001660; IPR013761; IPR011510; IPR011511; IPR001452; SAM and SH3 domain-containing protein 3 SASH3 Bos taurus (Bovine) TR30232_c1_g4_i3 O94885 SASH1_HUMAN 5.00E-24 IPR021090; IPR001660; IPR013761; IPR011510; IPR021129; IPR011511; IPR001452; SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) SASH1 KIAA0790 PEPE1 Homo sapiens (Human) TR30233_c2_g1_i1 P21328 RTJK_DROME 2.00E-31 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) TR30233_c2_g1_i2 Q03274 PO22_POPJA 3.00E-09 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis IPR000477; Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 (Retrovirus-related Pol polyprotein from type I retrotransposable element R2) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] (Fragment) Popillia japonica (Japanese beetle) TR30233_c2_g1_i4 P48166 RL44_CAEEL 8.00E-53 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000552; IPR011332; 60S ribosomal protein L44 (L41) rpl-41 C09H10.2 Caenorhabditis elegans TR30235_c2_g3_i1 Q9EPW9 TLR6_MOUSE 1.00E-09 GO:0002755; GO:0042088; GO:0035355; GO:0071726; GO:0042496; GO:0042498; GO:0006954; GO:0045087; GO:0016021; GO:0030670; GO:0043123; GO:0043507; GO:0045084; GO:0045410; GO:0050707; GO:0034150; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; T-helper 1 type immune response; Toll-like receptor 2-Toll-like receptor 6 protein complex; cellular response to diacyl bacterial lipopeptide; detection of diacyl bacterial lipopeptide; diacyl lipopeptide binding; inflammatory response; innate immune response; integral to membrane; phagocytic vesicle membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JUN kinase activity; positive regulation of interleukin-12 biosynthetic process; positive regulation of interleukin-6 biosynthetic process; regulation of cytokine secretion; toll-like receptor 6 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR025875; IPR003591; IPR000157; IPR027187; IPR017241; Toll-like receptor 6 (CD antigen CD286) Tlr6 Mus musculus (Mouse) TR30235_c2_g3_i2 Q6QNU9 TLR12_MOUSE 4.00E-10 GO:0006954; GO:0045087; GO:0016021; GO:0009617; GO:0034174; GO:0004888 inflammatory response; innate immune response; integral to membrane; response to bacterium; toll-like receptor 12 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR003591; IPR000157; IPR027195; Toll-like receptor 12 Tlr12 Gm1365 Mus musculus (Mouse) TR30235_c2_g3_i3 Q6R5N8 TLR13_MOUSE 4.00E-16 GO:0002755; GO:0005768; GO:0010008; GO:0006954; GO:0045087; GO:0016021; GO:0042803; GO:0019843; GO:0043408; GO:0002237; GO:0009615; GO:0034178; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; endosome; endosome membrane; inflammatory response; innate immune response; integral to membrane; protein homodimerization activity; rRNA binding; regulation of MAPK cascade; response to molecule of bacterial origin; response to virus; toll-like receptor 13 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR003591; IPR000157; IPR027196; Toll-like receptor 13 Tlr13 Mus musculus (Mouse) TR30237_c4_g2_i1 O08710 THYG_MOUSE 7.00E-06 GO:0005576; GO:0005615; GO:0042446; GO:0015705; GO:0031641; GO:0030878; GO:0006590 extracellular region; extracellular space; hormone biosynthetic process; iodide transport; regulation of myelination; thyroid gland development; thyroid hormone generation IPR002018; IPR019819; IPR016324; IPR000716; IPR011641; Thyroglobulin (Tg) Tg Tgn Mus musculus (Mouse) TR30237_c5_g3_i1 P16109 LYAM3_HUMAN 3.00E-08 GO:0050829; GO:0009897; GO:0005615; GO:0042806; GO:0043208; GO:0008201; GO:0007157; GO:0006954; GO:0005887; GO:0007159; GO:0050900; GO:0050901; GO:0001530; GO:0005634; GO:0070492; GO:0030168; GO:0031092; GO:0002576; GO:0031088; GO:0002687; GO:0014068; GO:0010572; GO:0033623; GO:0032496; GO:0033691 defense response to Gram-negative bacterium; external side of plasma membrane; extracellular space; fucose binding; glycosphingolipid binding; heparin binding; heterophilic cell-cell adhesion; inflammatory response; integral to plasma membrane; leukocyte cell-cell adhesion; leukocyte migration; leukocyte tethering or rolling; lipopolysaccharide binding; nucleus; oligosaccharide binding; platelet activation; platelet alpha granule membrane; platelet degranulation; platelet dense granule membrane; positive regulation of leukocyte migration; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of platelet activation; regulation of integrin activation; response to lipopolysaccharide; sialic acid binding IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR002396; IPR000436; P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P) SELP GMRP GRMP Homo sapiens (Human) TR30237_c5_g3_i2 Q6GP28 SRPX2_XENLA 3.00E-30 GO:0001525; GO:0007155; GO:0005737; GO:0005576 angiogenesis; cell adhesion; cytoplasm; extracellular region IPR025232; IPR003410; IPR000436; Sushi repeat-containing protein SRPX2 srpx2 Xenopus laevis (African clawed frog) TR30237_c5_g4_i2 Q28768 LYAM1_PAPHA 2.00E-06 GO:0030246; GO:0007155; GO:0016021 carbohydrate binding; cell adhesion; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR016348; IPR002396; IPR000436; L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (CD antigen CD62L) SELL Papio hamadryas (Hamadryas baboon) TR30238_c0_g1_i2 Q9DAN9 CQ105_MOUSE 3.00E-21 Uncharacterized protein C17orf105 homolog Mus musculus (Mouse) TR30241_c2_g1_i1 Q10076 YANB_SCHPO 3.00E-09 GO:0000978; GO:0046872; GO:0000790; GO:0043619; GO:0006351 "RNA polymerase II core promoter proximal region sequence-specific DNA binding; metal ion binding; nuclear chromatin; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Hydrogen peroxide stress regulator 1 hsr1 SPAC3H1.11 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR30242_c1_g1_i1 Q5XJQ7 OSR1_DANRE 1.00E-45 GO:0035779; GO:0048389; GO:0048382; GO:0046872; GO:0000122; GO:0003676; GO:0005634; GO:0033339; GO:0035777; GO:0035775; GO:0035778; GO:0035776; GO:0006351 "angioblast cell differentiation; intermediate mesoderm development; mesendoderm development; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleic acid binding; nucleus; pectoral fin development; pronephric distal tubule development; pronephric glomerulus morphogenesis; pronephric nephron tubule epithelial cell differentiation; pronephric proximal tubule development; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Protein odd-skipped-related 1 (zOsr1) osr1 si:dkey-199e17.1 zgc:101674 Danio rerio (Zebrafish) (Brachydanio rerio) TR30242_c1_g1_i2 Q32NK7 OSR2A_XENLA 9.00E-45 GO:0046872; GO:0000122; GO:0003676; GO:0005634; GO:0048793; GO:0006351 "metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleic acid binding; nucleus; pronephros development; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Protein odd-skipped-related 2-A (XOsr2) osr2-a osr2 Xenopus laevis (African clawed frog) TR30245_c0_g1_i1 Q9VCA2 ORCT_DROME 1.00E-60 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR30252_c1_g1_i1 P42893 ECE1_RAT 7.00E-28 GO:0006915; GO:0005769; GO:0009897; GO:0016021; GO:0046872; GO:0004222; GO:0045745; GO:0030819; GO:0010613; GO:0001921; GO:0042803; GO:0016485; GO:0006508; GO:0070372; GO:0008217; GO:0042312; GO:0046686; GO:0042493; GO:0001666; GO:0035994; GO:0030141 apoptotic process; early endosome; external side of plasma membrane; integral to membrane; metal ion binding; metalloendopeptidase activity; positive regulation of G-protein coupled receptor protein signaling pathway; positive regulation of cAMP biosynthetic process; positive regulation of cardiac muscle hypertrophy; positive regulation of receptor recycling; protein homodimerization activity; protein processing; proteolysis; regulation of ERK1 and ERK2 cascade; regulation of blood pressure; regulation of vasodilation; response to cadmium ion; response to drug; response to hypoxia; response to muscle stretch; secretory granule IPR024079; IPR000718; IPR018497; IPR008753; Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) Ece1 Rattus norvegicus (Rat) TR30252_c5_g1_i1 P42891 ECE1_BOVIN 2.00E-08 GO:0016021; GO:0016020; GO:0046872; GO:0004222; GO:0016486; GO:0005886; GO:0006508 integral to membrane; membrane; metal ion binding; metalloendopeptidase activity; peptide hormone processing; plasma membrane; proteolysis IPR024079; IPR000718; IPR018497; IPR008753; Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) ECE1 Bos taurus (Bovine) TR30253_c1_g1_i1 O14578 CTRO_HUMAN 4.00E-15 GO:0005524; GO:0015629; GO:0000910; GO:0016358; GO:0048699; GO:0035556; GO:0046872; GO:0007091; GO:0007067; GO:0000070; GO:0050774; GO:0005543; GO:0004674; GO:0001726; GO:0005083; GO:0007283; GO:0005773 ATP binding; actin cytoskeleton; cytokinesis; dendrite development; generation of neurons; intracellular signal transduction; metal ion binding; metaphase/anaphase transition of mitotic cell cycle; mitosis; mitotic sister chromatid segregation; negative regulation of dendrite morphogenesis; phospholipid binding; protein serine/threonine kinase activity; ruffle; small GTPase regulator activity; spermatogenesis; vacuole IPR000961; IPR001180; IPR017405; IPR011009; IPR011993; IPR017892; IPR001849; IPR002219; IPR000719; IPR017441; IPR020684; IPR002290; IPR008271; Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) CIT CRIK KIAA0949 STK21 Homo sapiens (Human) TR30258_c0_g1_i1 Q3T001 H17B6_BOVIN 1.00E-65 GO:0005789; GO:0004303; GO:0004745; GO:0008202; GO:0047035 endoplasmic reticulum membrane; estradiol 17-beta-dehydrogenase activity; retinol dehydrogenase activity; steroid metabolic process; testosterone dehydrogenase (NAD+) activity IPR002198; IPR002347; IPR016040; IPR020904; 17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.239) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) HSD17B6 Bos taurus (Bovine) TR30261_c0_g1_i1 Q03206 RAC1_CAEEL 2.00E-76 GO:0005525; GO:0003924; GO:0006915; GO:0048846; GO:0031103; GO:0010171; GO:0009986; GO:0031410; GO:0005829; GO:0033563; GO:0043652; GO:0016021; GO:0009898; GO:0008045; GO:0002119; GO:0001764; GO:0030334; GO:0050764; GO:0007264 GTP binding; GTPase activity; apoptotic process; axon extension involved in axon guidance; axon regeneration; body morphogenesis; cell surface; cytoplasmic vesicle; cytosol; dorsal/ventral axon guidance; engulfment of apoptotic cell; integral to membrane; internal side of plasma membrane; motor neuron axon guidance; nematode larval development; neuron migration; regulation of cell migration; regulation of phagocytosis; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Ras-related protein ced-10 (CErac1) (Cell death protein 10) (Cell-corpse engulfment protein ced-10) (Ras-related protein rac-1) ced-10 rac-1 C09G12.8 Caenorhabditis elegans TR30262_c0_g1_i1 Q8UVY2 BRX1_XENLA 1.00E-129 GO:0005730; GO:0042254 nucleolus; ribosome biogenesis IPR004154; IPR007109; IPR026532; Ribosome biogenesis protein BRX1 homolog (Brix domain-containing protein 2) (Bx24) brix1 brix bxdc2 Xenopus laevis (African clawed frog) TR30264_c0_g1_i1 Q8IRC7 AWH_DROME 5.00E-63 GO:0048749; GO:0007444; GO:0005634; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "compound eye development; imaginal disc development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR001356; IPR009057; IPR001781; LIM/homeobox protein Awh (Protein arrowhead) Awh CG1072 Drosophila melanogaster (Fruit fly) TR30264_c0_g1_i2 Q8IRC7 AWH_DROME 3.00E-61 GO:0048749; GO:0007444; GO:0005634; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "compound eye development; imaginal disc development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR001356; IPR009057; IPR001781; LIM/homeobox protein Awh (Protein arrowhead) Awh CG1072 Drosophila melanogaster (Fruit fly) TR30267_c1_g1_i2 B1WB06 MET24_XENTR 5.00E-16 GO:0005576; GO:0008168 extracellular region; methyltransferase activity IPR025714; IPR026913; Methyltransferase-like protein 24 (EC 2.1.1.-) mettl24 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30268_c1_g1_i1 Q5BKL8 XIAP_XENTR 1.00E-26 GO:0016055; GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0045861; GO:0008270 Wnt receptor signaling pathway; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; negative regulation of proteolysis; zinc ion binding IPR001370; IPR001841; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (X-linked inhibitor of apoptosis protein) (X-linked IAP) xiap birc4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30268_c1_g1_i2 Q13490 BIRC2_HUMAN 4.00E-17 GO:0035631; GO:0038061; GO:0035666; GO:0007166; GO:0006921; GO:0005829; GO:0045087; GO:0009898; GO:0070266; GO:0043066; GO:0005634; GO:0001890; GO:0043123; GO:0043161; GO:0000209; GO:0039535; GO:0051726; GO:0045595; GO:0042127; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0006355; GO:0034138; GO:0034142; GO:0003713; GO:0006351; GO:0004842; GO:0008270 P55210; Q9NR28; P63000; Q13546; O43353; Q9Y572; P57078; Q9NP84; Q12933 "CD40 receptor complex; NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; cell surface receptor signaling pathway; cellular component disassembly involved in execution phase of apoptosis; cytosol; innate immune response; internal side of plasma membrane; necroptosis; negative regulation of apoptotic process; nucleus; placenta development; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of RIG-I signaling pathway; regulation of cell cycle; regulation of cell differentiation; regulation of cell proliferation; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; regulation of transcription, DNA-dependent; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (IAP-2) (hIAP-2) (hIAP2) (RING finger protein 48) (TNFR2-TRAF-signaling complex protein 2) BIRC2 API1 IAP2 MIHB RNF48 Homo sapiens (Human) TR30268_c1_g1_i4 Q8JHV9 BIR7A_XENLA 1.00E-16 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR30268_c1_g1_i5 Q62210 BIRC2_MOUSE 6.00E-19 GO:0035631; GO:0006915; GO:0005737; GO:0009898; GO:0070266; GO:0060546; GO:1902443; GO:0005634; GO:0001890; GO:0043123; GO:0043161; GO:0070936; GO:0070534; GO:0042981; GO:0051726; GO:2000377; GO:0006355; GO:0003713; GO:0006351; GO:0004842; GO:0008270 "CD40 receptor complex; apoptotic process; cytoplasm; internal side of plasma membrane; necroptosis; negative regulation of necroptosis; negative regulation of ripoptosome assembly involved in necroptosis; nucleus; placenta development; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; protein K63-linked ubiquitination; regulation of apoptotic process; regulation of cell cycle; regulation of reactive oxygen species metabolic process; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (Inhibitor of apoptosis protein 2) (IAP-2) (mIAP-2) (mIAP2) Birc2 Birc3 Iap2 Mus musculus (Mouse) TR30268_c1_g1_i6 Q5BKL8 XIAP_XENTR 6.00E-28 GO:0016055; GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0045861; GO:0008270 Wnt receptor signaling pathway; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; negative regulation of proteolysis; zinc ion binding IPR001370; IPR001841; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (X-linked inhibitor of apoptosis protein) (X-linked IAP) xiap birc4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30269_c0_g2_i1 Q6NXI6 RPRD2_MOUSE 3.00E-35 GO:0016591 "DNA-directed RNA polymerase II, holoenzyme" IPR006569; IPR008942; IPR006903; Regulation of nuclear pre-mRNA domain-containing protein 2 Rprd2 Kiaa0460 Mus musculus (Mouse) TR30269_c1_g1_i1 Q9NQG5 RPR1B_HUMAN 2.00E-22 GO:0016591; GO:0000993; GO:0070940; GO:0008284; GO:0045944; GO:0010564; GO:0006351 P24928 "DNA-directed RNA polymerase II, holoenzyme; RNA polymerase II core binding; dephosphorylation of RNA polymerase II C-terminal domain; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell cycle process; transcription, DNA-dependent" IPR006569; IPR008942; IPR006903; Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) RPRD1B C20orf77 CREPT Homo sapiens (Human) TR30271_c0_g1_i1 P04069 CBPB_ASTFL 9.00E-91 GO:0005576; GO:0004181; GO:0006508; GO:0008270 extracellular region; metallocarboxypeptidase activity; proteolysis; zinc ion binding IPR000834; Carboxypeptidase B (EC 3.4.17.2) Astacus astacus (Noble crayfish) (Astacus fluviatilis) TR30271_c0_g1_i4 P19223 CBPB1_RAT 8.00E-79 GO:0004180; GO:0005576; GO:0004181; GO:0006508; GO:0008270 carboxypeptidase activity; extracellular region; metallocarboxypeptidase activity; proteolysis; zinc ion binding IPR000834; IPR003146; IPR009020; Carboxypeptidase B (EC 3.4.17.2) Cpb1 Cpb Rattus norvegicus (Rat) TR30273_c0_g1_i1 Q66JD1 ATPF1_XENTR 9.00E-51 GO:0005739; GO:0006461 mitochondrion; protein complex assembly IPR010591; ATP synthase mitochondrial F1 complex assembly factor 1 atpaf1 TGas084p20.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30276_c0_g1_i2 Q96B45 CJ032_HUMAN 2.00E-17 UPF0693 protein C10orf32 C10orf32 Homo sapiens (Human) TR30279_c1_g1_i1 Q2M389 WASH7_HUMAN 0 GO:0071203; GO:0016197; GO:0005768 WASH complex; endosomal transport; endosome IPR028283; IPR028282; IPR028191; IPR027307; WASH complex subunit 7 KIAA1033 Homo sapiens (Human) TR3028_c1_g1_i1 P04066 FUCO_HUMAN 3.00E-13 GO:0004560; GO:0042806; GO:0006004; GO:0006027; GO:0005764 alpha-L-fucosidase activity; fucose binding; fucose metabolic process; glycosaminoglycan catabolic process; lysosome IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) FUCA1 Nbla10230 Homo sapiens (Human) TR30280_c0_g1_i1 Q15008 PSMD6_HUMAN 0 GO:0016887; GO:0006977; GO:0000082; GO:0031145; GO:0002479; GO:0006915; GO:0005829; GO:0010467; GO:0016071; GO:0043066; GO:0051436; GO:0005654; GO:0051437; GO:0022624; GO:0000209; GO:0006521; GO:0016032 "ATPase activity; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G1/S transition of mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic process; cytosol; gene expression; mRNA metabolic process; negative regulation of apoptotic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; proteasome accessory complex; protein polyubiquitination; regulation of cellular amino acid metabolic process; viral process" IPR019585; IPR000717; IPR011991; 26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A) PSMD6 KIAA0107 PFAAP4 Homo sapiens (Human) TR30280_c1_g2_i1 Q6PBY7 CE044_DANRE 0 IPR010378; Trafficking protein particle complex subunit 13 trappc13 zgc:73187 Danio rerio (Zebrafish) (Brachydanio rerio) TR30282_c1_g1_i1 Q54P77 4CL1_DICDI 2.00E-87 GO:0016207; GO:0005524; GO:0009698 4-coumarate-CoA ligase activity; ATP binding; phenylpropanoid metabolic process IPR025110; IPR000873; "Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2." Probable 4-coumarate--CoA ligase 1 (4CL 1) (EC 6.2.1.12) (4-coumaroyl-CoA synthase 1) 4cl1 DDB_G0284831 Dictyostelium discoideum (Slime mold) TR30282_c1_g3_i1 Q3ZKN0 S27A1_BOVIN 7.00E-12 GO:0005737; GO:0012505; GO:0006631; GO:0016021; GO:0016874; GO:0006869; GO:0000166; GO:0005886 cytoplasm; endomembrane system; fatty acid metabolic process; integral to membrane; ligase activity; lipid transport; nucleotide binding; plasma membrane IPR025110; IPR020845; IPR000873; Long-chain fatty acid transport protein 1 (FATP-1) (Fatty acid transport protein 1) (EC 6.2.1.-) (Solute carrier family 27 member 1) SLC27A1 FATP1 Bos taurus (Bovine) TR30283_c0_g1_i1 Q4R627 LARP7_MACFA 9.00E-50 GO:0003723; GO:0006396; GO:0005654; GO:0000166; GO:0030529 RNA binding; RNA processing; nucleoplasm; nucleotide binding; ribonucleoprotein complex IPR002344; IPR006630; IPR012677; IPR014886; IPR000504; IPR011991; La-related protein 7 (La ribonucleoprotein domain family member 7) LARP7 QtsA-19289 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR30285_c3_g1_i1 Q8C0V9 FRMD6_MOUSE 2.00E-72 GO:0003383; GO:0043296; GO:0034613; GO:0005856; GO:0005739; GO:0005886; GO:0032970 apical constriction; apical junction complex; cellular protein localization; cytoskeleton; mitochondrion; plasma membrane; regulation of actin filament-based process IPR019749; IPR014352; IPR019748; IPR000299; IPR018979; IPR018980; IPR011993; FERM domain-containing protein 6 Frmd6 Mus musculus (Mouse) TR30288_c0_g1_i1 P86734 EPDR1_HALAI 9.00E-20 GO:0005509; GO:0007160; GO:0005576 calcium ion binding; cell-matrix adhesion; extracellular region IPR001299; Ependymin-related protein 1 Sometsuke Haliotis asinina (Donkey's ear abalone) (Ass's ear abalone) TR30289_c0_g1_i1 Q8AVR4 PDC10_XENLA 1.00E-44 GO:0000139; GO:0001525; GO:0006915; GO:0005886 Golgi membrane; angiogenesis; apoptotic process; plasma membrane IPR009652; Programmed cell death protein 10 pdcd10 Xenopus laevis (African clawed frog) TR30290_c0_g1_i1 Q96ME1 FXL18_HUMAN 1.00E-23 IPR001810; F-box/LRR-repeat protein 18 (F-box and leucine-rich repeat protein 18) FBXL18 FBL18 Homo sapiens (Human) TR30294_c0_g1_i1 A8MV24 CQ098_HUMAN 1.00E-35 IPR028027; Uncharacterized protein C17orf98 C17orf98 Homo sapiens (Human) TR30295_c0_g1_i1 Q91V01 MBOA5_MOUSE 2.00E-123 GO:0047184; GO:0005789; GO:0016021; GO:0008654; GO:0097006 1-acylglycerophosphocholine O-acyltransferase activity; endoplasmic reticulum membrane; integral to membrane; phospholipid biosynthetic process; regulation of plasma lipoprotein particle levels IPR004299; Lipid metabolism; phospholipid metabolism. Lysophospholipid acyltransferase 5 (LPLAT 5) (EC 2.3.1.-) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Lysophosphatidylcholine acyltransferase 3) (Lyso-PC acyltransferase 3) (mLPCAT3) (Lysophosphatidylethanolamine acyltransferase) (LPEAT) (Lyso-PE acyltransferase) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 5) (O-acyltransferase domain-containing protein 5) Lpcat3 Grcc3f Mboat5 Oact5 Mus musculus (Mouse) TR30296_c0_g1_i2 Q9W4K2 Y3556_DROME 4.00E-09 GO:0031419; GO:0015889; GO:0005576 cobalamin binding; cobalamin transport; extracellular region IPR002157; IPR019554; IPR008930; Uncharacterized protein CG3556 CG3556 Drosophila melanogaster (Fruit fly) TR30296_c0_g1_i3 Q9XSC9 TCO2_BOVIN 3.00E-14 GO:0031419; GO:0009235; GO:0015889; GO:0006824; GO:0005576; GO:0046872 cobalamin binding; cobalamin metabolic process; cobalamin transport; cobalt ion transport; extracellular region; metal ion binding IPR002157; Transcobalamin-2 (TC-2) (Transcobalamin II) (TC II) (TCII) TCN2 Bos taurus (Bovine) TR30298_c0_g1_i1 Q17BB0 WDR12_AEDAE 1.00E-75 GO:0070545; GO:0000463; GO:0005654 "PeBoW complex; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleoplasm" IPR020472; IPR012972; IPR015943; IPR001680; IPR019775; IPR017986; Ribosome biogenesis protein WDR12 homolog AAEL005041 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR30298_c0_g3_i1 A8QB65 WDR12_BRUMA 5.00E-46 GO:0070545; GO:0000463; GO:0005654 "PeBoW complex; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleoplasm" IPR020472; IPR012972; IPR015943; IPR001680; IPR019775; IPR017986; Ribosome biogenesis protein WDR12 homolog Bm1_47965 Brugia malayi (Filarial nematode worm) TR30300_c1_g1_i1 Q6P1E7 CC111_MOUSE 2.00E-101 GO:0003896 DNA primase activity IPR002755; IPR004340; Coiled-coil domain-containing protein 111 (DNA-directed primase/polymerase protein) Primpol Ccdc111 Mus musculus (Mouse) TR30301_c0_g1_i1 Q3SYG4 PTHB1_HUMAN 2.00E-52 GO:0034464; GO:0060170; GO:0005737; GO:0045444; GO:0005815; GO:0005634; GO:0005886; GO:0050896; GO:0007601 Q8NFJ9; Q8TAM1; Q6ZW61; Q9BXC9; Q8N3I7; Q9NQ48; Q8TAM2 BBSome; cilium membrane; cytoplasm; fat cell differentiation; microtubule organizing center; nucleus; plasma membrane; response to stimulus; visual perception IPR028074; IPR028073; IPR026511; Protein PTHB1 (Bardet-Biedl syndrome 9 protein) (Parathyroid hormone-responsive B1 gene protein) BBS9 PTHB1 Homo sapiens (Human) TR30302_c1_g1_i2 P27105 STOM_HUMAN 5.00E-64 GO:0005737; GO:0005856; GO:0070062; GO:0005887; GO:0042470; GO:0045121; GO:0051260 cytoplasm; cytoskeleton; extracellular vesicular exosome; integral to plasma membrane; melanosome; membrane raft; protein homooligomerization IPR001107; IPR018080; IPR001972; Erythrocyte band 7 integral membrane protein (Protein 7.2b) (Stomatin) STOM BND7 EPB72 Homo sapiens (Human) TR30303_c1_g1_i3 Q8QGW7 LITAF_CHICK 1.00E-17 GO:0005125; GO:0005737; GO:0006355; GO:0006351 "cytokine activity; cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) TR30304_c0_g1_i2 Q24799 MYPH_ECHGR 2.00E-46 IPR000557; IPR001715; IPR003096; Myophilin Echinococcus granulosus TR30304_c0_g1_i3 Q15417 CNN3_HUMAN 9.00E-47 GO:0003779; GO:0031032; GO:0005516; GO:0043197; GO:0032780; GO:0043025; GO:0014069; GO:0006939; GO:0005523; GO:0030172 actin binding; actomyosin structure organization; calmodulin binding; dendritic spine; negative regulation of ATPase activity; neuronal cell body; postsynaptic density; smooth muscle contraction; tropomyosin binding; troponin C binding IPR001997; IPR000557; IPR001715; IPR003096; "Calponin-3 (Calponin, acidic isoform)" CNN3 Homo sapiens (Human) TR30305_c0_g1_i1 Q13114 TRAF3_HUMAN 4.00E-30 GO:0035631; GO:0035666; GO:0008063; GO:0006915; GO:0005829; GO:0005768; GO:0045087; GO:0009898; GO:0005739; GO:0032088; GO:0032480; GO:0042981; GO:0050688; GO:0032648; GO:0030162; GO:0004871; GO:0034138; GO:0034142; GO:0033209; GO:0004842; GO:0008270 Q9QYP6; P15056; P25942; P15314; Q92844; Q8TDR0; A2APF7; Q15326 CD40 receptor complex; TRIF-dependent toll-like receptor signaling pathway; Toll signaling pathway; apoptotic process; cytosol; endosome; innate immune response; internal side of plasma membrane; mitochondrion; negative regulation of NF-kappaB transcription factor activity; negative regulation of type I interferon production; regulation of apoptotic process; regulation of defense response to virus; regulation of interferon-beta production; regulation of proteolysis; signal transducer activity; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; tumor necrosis factor-mediated signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR013323; IPR012227; IPR008974; IPR027128; IPR001841; IPR013083; IPR017907; IPR001293; TNF receptor-associated factor 3 (EC 6.3.2.-) (CAP-1) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) TRAF3 CAP1 CRAF1 Homo sapiens (Human) TR30305_c0_g1_i2 Q9UPQ7 PZRN3_HUMAN 5.00E-11 GO:0031594; GO:0007528; GO:0004842; GO:0008270 neuromuscular junction; neuromuscular junction development; ubiquitin-protein ligase activity; zinc ion binding IPR001478; IPR013323; IPR008974; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase PDZRN3 (EC 6.3.2.-) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) PDZRN3 KIAA1095 LNX3 SEMCAP3 Homo sapiens (Human) TR30305_c0_g1_i3 Q61382 TRAF4_MOUSE 3.00E-32 GO:0006915; GO:0005737; GO:0005856; GO:0005634; GO:0048471; GO:0005886; GO:0046330; GO:0090073; GO:0045860; GO:0042981; GO:0007585; GO:0030323; GO:0007165; GO:0005923; GO:0004842; GO:0008270 apoptotic process; cytoplasm; cytoskeleton; nucleus; perinuclear region of cytoplasm; plasma membrane; positive regulation of JNK cascade; positive regulation of protein homodimerization activity; positive regulation of protein kinase activity; regulation of apoptotic process; respiratory gaseous exchange; respiratory tube development; signal transduction; tight junction; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR013323; IPR012227; IPR008974; IPR018957; IPR001841; IPR013083; IPR017907; IPR001293; TNF receptor-associated factor 4 (Cysteine-rich motif associated to RING and Traf domains protein 1) Traf4 Cart1 Mus musculus (Mouse) TR30307_c0_g1_i1 Q9DDA9 PACN2_XENLA 2.00E-94 GO:0005901; GO:0030659; GO:0005856; GO:0005769; GO:0006897; GO:0070300; GO:0032587 caveola; cytoplasmic vesicle membrane; cytoskeleton; early endosome; endocytosis; phosphatidic acid binding; ruffle membrane IPR001060; IPR001452; Protein kinase C and casein kinase substrate in neurons protein 2 (x-PACSIN2) pacsin2 Xenopus laevis (African clawed frog) TR30307_c0_g1_i2 Q9WVE8 PACN2_MOUSE 6.00E-96 GO:0005901; GO:0070836; GO:0072584; GO:0048858; GO:0030659; GO:0008092; GO:0005856; GO:0005829; GO:0005769; GO:0019898; GO:0097320; GO:0045806; GO:0070300; GO:0032587; GO:0007165 caveola; caveola assembly; caveolin-mediated endocytosis; cell projection morphogenesis; cytoplasmic vesicle membrane; cytoskeletal protein binding; cytoskeleton; cytosol; early endosome; extrinsic to membrane; membrane tubulation; negative regulation of endocytosis; phosphatidic acid binding; ruffle membrane; signal transduction IPR001060; IPR001452; Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) Pacsin2 Mus musculus (Mouse) TR30310_c0_g1_i1 Q99ND9 RWDD1_RAT 2.00E-45 IPR006575; IPR016135; RWD domain-containing protein 1 (Small androgen receptor-interacting protein) Rwdd1 Sarip Rattus norvegicus (Rat) TR30310_c0_g1_i2 Q9CQK7 RWDD1_MOUSE 2.00E-44 IPR006575; IPR016135; RWD domain-containing protein 1 (DRG family-regulatory protein 2) (IH1) Rwdd1 Dfrp2 Mus musculus (Mouse) TR30313_c0_g1_i1 P46874 KLP2_BOMMO 9.00E-35 GO:0005524; GO:0051301; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0007018; GO:0007067 ATP binding; cell division; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement; mitosis IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KLP2 (Fragment) Bombyx mori (Silk moth) TR30313_c0_g2_i1 P27895 CIN8_YEAST 5.00E-32 GO:0005524; GO:0000235; GO:0051301; GO:0000778; GO:0005871; GO:0005828; GO:0007019; GO:0007018; GO:0008569; GO:0005739; GO:0000070; GO:0000022; GO:0030472; GO:0008574; GO:0090307; GO:0000073 ATP binding; astral microtubule; cell division; condensed nuclear chromosome kinetochore; kinesin complex; kinetochore microtubule; microtubule depolymerization; microtubule-based movement; minus-end-directed microtubule motor activity; mitochondrion; mitotic sister chromatid segregation; mitotic spindle elongation; mitotic spindle organization in nucleus; plus-end-directed microtubule motor activity; spindle assembly involved in mitosis; spindle pole body separation IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein CIN8 (Chromosome instability protein 8) CIN8 KSL2 YEL061C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR30313_c1_g1_i1 P52732 KIF11_HUMAN 1.00E-71 GO:0005524; GO:0019886; GO:0007596; GO:0051301; GO:0005829; GO:0005871; GO:0005874; GO:0003777; GO:0007018; GO:0007100; GO:0032403; GO:0005819; GO:0090307; GO:0000922 ATP binding; antigen processing and presentation of exogenous peptide antigen via MHC class II; blood coagulation; cell division; cytosol; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement; mitotic centrosome separation; protein complex binding; spindle; spindle assembly involved in mitosis; spindle pole IPR025901; IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) KIF11 EG5 KNSL1 TRIP5 Homo sapiens (Human) TR30314_c0_g1_i1 Q5R5J3 PKRI1_PONAB 1.00E-34 GO:0003725; GO:0005730; GO:0004860 double-stranded RNA binding; nucleolus; protein kinase inhibitor activity IPR009548; PRKR-interacting protein 1 PRKRIP1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR30315_c0_g1_i1 P83088 FUCTC_DROME 2.00E-22 GO:0032580; GO:0036065; GO:0008417; GO:0016021; GO:0006486 Golgi cisterna membrane; fucosylation; fucosyltransferase activity; integral to membrane; protein glycosylation IPR001503; Protein modification; protein glycosylation. "Alpha-(1,3)-fucosyltransferase C (EC 2.4.1.-) (Galactoside 3-L-fucosyltransferase)" FucTC CG40305 Drosophila melanogaster (Fruit fly) TR30317_c0_g1_i2 Q5TZ51 MPV17_DANRE 1.00E-34 GO:0016021; GO:0005743 integral to membrane; mitochondrial inner membrane IPR007248; Protein Mpv17 mpv17 zgc:63573 Danio rerio (Zebrafish) (Brachydanio rerio) TR30317_c0_g1_i3 Q60SZ2 MPV17_CAEBR 7.00E-21 GO:0016021; GO:0005743 integral to membrane; mitochondrial inner membrane IPR007248; Mpv17-like protein (Fragment) CBG20693 Caenorhabditis briggsae TR30318_c1_g1_i1 Q5F389 WWOX_CHICK 4.00E-27 GO:0016055; GO:0006915; GO:0005737; GO:0005634; GO:0016491 Wnt receptor signaling pathway; apoptotic process; cytoplasm; nucleus; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR001202; WW domain-containing oxidoreductase (EC 1.1.1.-) WWOX RCJMB04_28b1 Gallus gallus (Chicken) TR30319_c0_g1_i1 Q03333 NEC2_PIG 0 GO:0006508; GO:0004252; GO:0030133 proteolysis; serine-type endopeptidase activity; transport vesicle IPR008979; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2) PCSK2 PC2 Sus scrofa (Pig) TR30323_c0_g2_i1 E1BD59 TRI56_BOVIN 4.00E-07 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) TR30330_c0_g1_i2 Q04833 LRP_CAEEL 1.00E-22 GO:0016324; GO:0005509; GO:0005905; GO:0042395; GO:0030139; GO:0006897; GO:0016021; GO:0002119; GO:0040017; GO:0040018; GO:0030334; GO:0015248 "apical plasma membrane; calcium ion binding; coated pit; ecdysis, collagen and cuticulin-based cuticle; endocytic vesicle; endocytosis; integral to membrane; nematode larval development; positive regulation of locomotion; positive regulation of multicellular organism growth; regulation of cell migration; sterol transporter activity" IPR011042; IPR000742; IPR001881; IPR013032; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein (LRP) lrp-1 F29D11.1 Caenorhabditis elegans TR30330_c0_g1_i3 P35951 LDLR_MOUSE 2.00E-09 GO:0005794; GO:0005509; GO:0009986; GO:0042632; GO:0070508; GO:0008203; GO:0005905; GO:0005769; GO:0009897; GO:0016021; GO:0030299; GO:0005770; GO:0042159; GO:0034362; GO:0030169; GO:0034383; GO:0005041; GO:0005764; GO:0015914; GO:0005886; GO:0010867; GO:0010899; GO:0030229 Golgi apparatus; calcium ion binding; cell surface; cholesterol homeostasis; cholesterol import; cholesterol metabolic process; coated pit; early endosome; external side of plasma membrane; integral to membrane; intestinal cholesterol absorption; late endosome; lipoprotein catabolic process; low-density lipoprotein particle; low-density lipoprotein particle binding; low-density lipoprotein particle clearance; low-density lipoprotein receptor activity; lysosome; phospholipid transport; plasma membrane; positive regulation of triglyceride biosynthetic process; regulation of phosphatidylcholine catabolic process; very-low-density lipoprotein particle receptor activity IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor (LDL receptor) Ldlr Mus musculus (Mouse) TR30331_c0_g1_i1 Q9NRA2 S17A5_HUMAN 3.00E-116 GO:0006865; GO:0030054; GO:0005887; GO:0005765; GO:0015136; GO:0015739; GO:0005351; GO:0030672 amino acid transport; cell junction; integral to plasma membrane; lysosomal membrane; sialic acid transmembrane transporter activity; sialic acid transport; sugar:hydrogen symporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) TR30331_c0_g1_i3 Q03567 YLD2_CAEEL 6.00E-106 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR011701; IPR020846; IPR016196; Uncharacterized transporter C38C10.2 C38C10.2 Caenorhabditis elegans TR30331_c0_g1_i4 Q03567 YLD2_CAEEL 4.00E-106 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR011701; IPR020846; IPR016196; Uncharacterized transporter C38C10.2 C38C10.2 Caenorhabditis elegans TR30331_c0_g1_i5 Q9NRA2 S17A5_HUMAN 3.00E-116 GO:0006865; GO:0030054; GO:0005887; GO:0005765; GO:0015136; GO:0015739; GO:0005351; GO:0030672 amino acid transport; cell junction; integral to plasma membrane; lysosomal membrane; sialic acid transmembrane transporter activity; sialic acid transport; sugar:hydrogen symporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) TR30334_c0_g1_i1 Q5BKR2 SL9B2_MOUSE 1.00E-43 GO:0016021; GO:0031966; GO:0006814; GO:0015299 integral to membrane; mitochondrial membrane; sodium ion transport; solute:hydrogen antiporter activity IPR006153; Mitochondrial sodium/hydrogen exchanger 9B2 (Mitochondrial Na(+)/H(+) exchanger NHA2) (NHA-oc) (Na(+)/H(+) exchanger-like domain-containing protein 2) (NHE domain-containing protein 2) (Sodium/hydrogen exchanger-like domain-containing protein 2) (Solute carrier family 9 subfamily B member 2) Slc9b2 Nha2 Nhedc2 Mus musculus (Mouse) TR30334_c7_g1_i2 Q5BKR2 SL9B2_MOUSE 3.00E-51 GO:0016021; GO:0031966; GO:0006814; GO:0015299 integral to membrane; mitochondrial membrane; sodium ion transport; solute:hydrogen antiporter activity IPR006153; Mitochondrial sodium/hydrogen exchanger 9B2 (Mitochondrial Na(+)/H(+) exchanger NHA2) (NHA-oc) (Na(+)/H(+) exchanger-like domain-containing protein 2) (NHE domain-containing protein 2) (Sodium/hydrogen exchanger-like domain-containing protein 2) (Solute carrier family 9 subfamily B member 2) Slc9b2 Nha2 Nhedc2 Mus musculus (Mouse) TR30335_c1_g1_i1 Q2KIA4 SCD5_BOVIN 1.00E-137 GO:0005789; GO:0006633; GO:0016021; GO:0005506; GO:0004768 endoplasmic reticulum membrane; fatty acid biosynthetic process; integral to membrane; iron ion binding; stearoyl-CoA 9-desaturase activity IPR005804; IPR001522; IPR015876; Stearoyl-CoA desaturase 5 (EC 1.14.19.1) (Acyl-CoA-desaturase 4) (Stearoyl-CoA 9-desaturase) SCD5 Bos taurus (Bovine) TR30335_c1_g1_i2 Q2KIA4 SCD5_BOVIN 1.00E-138 GO:0005789; GO:0006633; GO:0016021; GO:0005506; GO:0004768 endoplasmic reticulum membrane; fatty acid biosynthetic process; integral to membrane; iron ion binding; stearoyl-CoA 9-desaturase activity IPR005804; IPR001522; IPR015876; Stearoyl-CoA desaturase 5 (EC 1.14.19.1) (Acyl-CoA-desaturase 4) (Stearoyl-CoA 9-desaturase) SCD5 Bos taurus (Bovine) TR30336_c0_g1_i2 Q6UWH6 TX261_HUMAN 2.00E-71 GO:0016021 integral to membrane IPR007277; Protein TEX261 TEX261 UNQ1882/PRO4325 Homo sapiens (Human) TR30339_c1_g4_i1 Q5R5S4 PSMD1_PONAB 1.00E-14 GO:0030234; GO:0022624; GO:0050790; GO:0042176 enzyme regulator activity; proteasome accessory complex; regulation of catalytic activity; regulation of protein catabolic process IPR016642; IPR011989; IPR016024; IPR002015; 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) PSMD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR3034_c0_g1_i1 O14082 YEAH_SCHPO 1.00E-37 GO:0005829; GO:0005634; GO:0055114; GO:0016491 cytosol; nucleus; oxidation-reduction process; oxidoreductase activity IPR016040; IPR000683; IPR013944; Uncharacterized protein UNK4.17 SPAC2E11.17 SPACUNK4.17 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR30340_c0_g2_i1 Q93075 TATD2_HUMAN 7.00E-39 GO:0006987; GO:0044267; GO:0016888; GO:0046872; GO:0090305; GO:0005654 "activation of signaling protein activity involved in unfolded protein response; cellular protein metabolic process; endodeoxyribonuclease activity, producing 5'-phosphomonoesters; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleoplasm" IPR018228; IPR001130; Putative deoxyribonuclease TATDN2 (EC 3.1.21.-) TATDN2 KIAA0218 Homo sapiens (Human) TR30341_c3_g1_i1 P56161 ACES_ANOST 7.00E-45 GO:0001507; GO:0003990; GO:0031225; GO:0004091; GO:0030054; GO:0005886; GO:0045202 acetylcholine catabolic process in synaptic cleft; acetylcholinesterase activity; anchored to membrane; carboxylesterase activity; cell junction; plasma membrane; synapse IPR001445; IPR002018; IPR019826; IPR019819; IPR000997; Acetylcholinesterase (AChE) (EC 3.1.1.7) Anopheles stephensi (Indo-Pakistan malaria mosquito) TR30341_c3_g1_i2 P06276 CHLE_HUMAN 6.00E-62 GO:0003990; GO:0001540; GO:0004091; GO:0044267; GO:0019695; GO:0050783; GO:0005788; GO:0019899; GO:0005615; GO:0016020; GO:0005641; GO:0007271 Itself "acetylcholinesterase activity; beta-amyloid binding; carboxylesterase activity; cellular protein metabolic process; choline metabolic process; cocaine metabolic process; endoplasmic reticulum lumen; enzyme binding; extracellular space; membrane; nuclear envelope lumen; synaptic transmission, cholinergic" IPR014788; IPR002018; IPR019826; IPR019819; IPR000997; Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase) BCHE CHE1 Homo sapiens (Human) TR30341_c3_g1_i3 P56161 ACES_ANOST 7.00E-48 GO:0001507; GO:0003990; GO:0031225; GO:0004091; GO:0030054; GO:0005886; GO:0045202 acetylcholine catabolic process in synaptic cleft; acetylcholinesterase activity; anchored to membrane; carboxylesterase activity; cell junction; plasma membrane; synapse IPR001445; IPR002018; IPR019826; IPR019819; IPR000997; Acetylcholinesterase (AChE) (EC 3.1.1.7) Anopheles stephensi (Indo-Pakistan malaria mosquito) TR30341_c3_g1_i4 O62761 CHLE_PANTT 2.00E-58 GO:0003990; GO:0004091; GO:0005576; GO:0016020 acetylcholinesterase activity; carboxylesterase activity; extracellular region; membrane IPR014788; IPR002018; IPR019826; IPR019819; IPR000997; Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase) BCHE Panthera tigris tigris (Bengal tiger) TR30341_c3_g1_i5 P06276 CHLE_HUMAN 1.00E-64 GO:0003990; GO:0001540; GO:0004091; GO:0044267; GO:0019695; GO:0050783; GO:0005788; GO:0019899; GO:0005615; GO:0016020; GO:0005641; GO:0007271 Itself "acetylcholinesterase activity; beta-amyloid binding; carboxylesterase activity; cellular protein metabolic process; choline metabolic process; cocaine metabolic process; endoplasmic reticulum lumen; enzyme binding; extracellular space; membrane; nuclear envelope lumen; synaptic transmission, cholinergic" IPR014788; IPR002018; IPR019826; IPR019819; IPR000997; Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase) BCHE CHE1 Homo sapiens (Human) TR30341_c3_g1_i6 P22303 ACES_HUMAN 7.00E-56 GO:0006260; GO:0005794; GO:0042166; GO:0001507; GO:0003990; GO:0042982; GO:0031225; GO:0030424; GO:0005605; GO:0001540; GO:0004091; GO:0007155; GO:0030054; GO:0008283; GO:0009986; GO:0019695; GO:0005518; GO:0030425; GO:0005788; GO:0005615; GO:0043236; GO:0007517; GO:0032223; GO:0031594; GO:0042136; GO:0045212; GO:0005634; GO:0002076; GO:0048471; GO:0006656; GO:0050714; GO:0045211; GO:0042734; GO:0042803; GO:0051262; GO:0031623; GO:0050770; GO:0048814; GO:0001919; GO:0009611; GO:0060041; GO:0017171; GO:0007416 Q9Y215; P06733; P63244 "DNA replication; Golgi apparatus; acetylcholine binding; acetylcholine catabolic process in synaptic cleft; acetylcholinesterase activity; amyloid precursor protein metabolic process; anchored to membrane; axon; basal lamina; beta-amyloid binding; carboxylesterase activity; cell adhesion; cell junction; cell proliferation; cell surface; choline metabolic process; collagen binding; dendrite; endoplasmic reticulum lumen; extracellular space; laminin binding; muscle organ development; negative regulation of synaptic transmission, cholinergic; neuromuscular junction; neurotransmitter biosynthetic process; neurotransmitter receptor biosynthetic process; nucleus; osteoblast development; perinuclear region of cytoplasm; phosphatidylcholine biosynthetic process; positive regulation of protein secretion; postsynaptic membrane; presynaptic membrane; protein homodimerization activity; protein tetramerization; receptor internalization; regulation of axonogenesis; regulation of dendrite morphogenesis; regulation of receptor recycling; response to wounding; retina development in camera-type eye; serine hydrolase activity; synapse assembly" IPR014788; IPR002018; IPR019826; IPR019819; IPR000997; Acetylcholinesterase (AChE) (EC 3.1.1.7) ACHE Homo sapiens (Human) TR30342_c0_g1_i1 B4F7A7 CEP57_RAT 5.00E-11 GO:0005794; GO:0008543; GO:0005874; GO:0034453; GO:0005815; GO:0005634; GO:0051260; GO:0000060; GO:0007286 "Golgi apparatus; fibroblast growth factor receptor signaling pathway; microtubule; microtubule anchoring; microtubule organizing center; nucleus; protein homooligomerization; protein import into nucleus, translocation; spermatid development" IPR010597; IPR025913; IPR024957; Centrosomal protein of 57 kDa (Cep57) (Translokin) Cep57 Rattus norvegicus (Rat) TR30342_c0_g2_i3 Q6AXZ4 CE57L_RAT 9.00E-06 GO:0005737; GO:0005874; GO:0034453; GO:0005815 cytoplasm; microtubule; microtubule anchoring; microtubule organizing center IPR010597; IPR025913; IPR024957; Centrosomal protein CEP57L1 (Centrosomal protein 57kDa-like protein 1) (Centrosomal protein of 57 kDa-related protein) (Cep57R) (Cep57-related protein) Cep57l1 Cep57r Rattus norvegicus (Rat) TR30342_c2_g1_i1 Q5FWP9 CE57L_XENLA 7.00E-15 GO:0008608; GO:0005813; GO:0000777; GO:0005737; GO:0043015; GO:0000776; GO:0005876 attachment of spindle microtubules to kinetochore; centrosome; condensed chromosome kinetochore; cytoplasm; gamma-tubulin binding; kinetochore; spindle microtubule IPR010597; IPR025913; IPR024957; Centrosomal protein cep57l1 (Centrosomal protein 57kDa-like protein 1) (Centrosomal protein of 57 kDa) (Cep57) (XCep57) (Cep57-related protein) (Cep57R) cep57l1 cep57 cep57r Xenopus laevis (African clawed frog) TR30342_c5_g1_i1 Q86XR8 CEP57_HUMAN 6.00E-19 GO:0000086; GO:0005794; GO:0005813; GO:0005829; GO:0008543; GO:0005874; GO:0034453; GO:0005634; GO:0051260; GO:0000060; GO:0007286 P01106 "G2/M transition of mitotic cell cycle; Golgi apparatus; centrosome; cytosol; fibroblast growth factor receptor signaling pathway; microtubule; microtubule anchoring; nucleus; protein homooligomerization; protein import into nucleus, translocation; spermatid development" IPR010597; IPR025913; IPR024957; Centrosomal protein of 57 kDa (Cep57) (FGF2-interacting protein) (Testis-specific protein 57) (Translokin) CEP57 KIAA0092 TSP57 Homo sapiens (Human) TR30343_c0_g1_i1 A6QQM4 ZN474_BOVIN 4.00E-19 GO:0046872 metal ion binding IPR026319; Zinc finger protein 474 ZNF474 Bos taurus (Bovine) TR30347_c0_g1_i1 Q5R995 CELF1_PONAB 9.00E-08 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0000166; GO:0005634; GO:0043484 RNA binding; RNA splicing; cytoplasm; mRNA processing; nucleotide binding; nucleus; regulation of RNA splicing IPR012677; IPR000504; CUGBP Elav-like family member 1 (CELF-1) (Bruno-like protein 2) (CUG triplet repeat RNA-binding protein 1) (CUG-BP1) (CUG-BP- and ETR-3-like factor 1) (RNA-binding protein BRUNOL-2) CELF1 CUGBP1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR30347_c0_g1_i2 O94432 YHKF_SCHPO 1.00E-41 GO:0005737; GO:0003730; GO:0006379; GO:0005849; GO:0006378; GO:0000166 cytoplasm; mRNA 3'-UTR binding; mRNA cleavage; mRNA cleavage factor complex; mRNA polyadenylation; nucleotide binding IPR012677; IPR000504; Uncharacterized RNA-binding protein C660.15 SPBC660.15 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR30347_c0_g1_i3 Q2HJ60 ROA2_BOVIN 2.00E-67 GO:0003723; GO:0008380; GO:0050658; GO:0071013; GO:0005737; GO:0006397; GO:0005730; GO:0005654; GO:0000166; GO:0030529; GO:0043047 RNA binding; RNA splicing; RNA transport; catalytic step 2 spliceosome; cytoplasm; mRNA processing; nucleolus; nucleoplasm; nucleotide binding; ribonucleoprotein complex; single-stranded telomeric DNA binding IPR012677; IPR000504; Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) HNRNPA2B1 HNRPA2B1 Bos taurus (Bovine) TR30347_c0_g1_i4 Q14498 RBM39_HUMAN 4.00E-17 GO:0003723; GO:0006396; GO:0008380; GO:0005813; GO:0006397; GO:0016607; GO:0005654; GO:0000166; GO:0006355; GO:0006351 Q96SB4; P78362 "RNA binding; RNA processing; RNA splicing; centrosome; mRNA processing; nuclear speck; nucleoplasm; nucleotide binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006509; IPR012677; IPR000504; RNA-binding protein 39 (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1) RBM39 HCC1 RNPC2 Homo sapiens (Human) TR30347_c0_g1_i5 P04256 ROA1_RAT 2.00E-66 GO:0003723; GO:0016070; GO:0008380; GO:0005737; GO:0006397; GO:0051028; GO:0051168; GO:0051170; GO:0005654; GO:0000166; GO:0003697; GO:0005681 RNA binding; RNA metabolic process; RNA splicing; cytoplasm; mRNA processing; mRNA transport; nuclear export; nuclear import; nucleoplasm; nucleotide binding; single-stranded DNA binding; spliceosomal complex IPR021662; IPR012677; IPR000504; "Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (HDP) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]" Hnrnpa1 Hnrpa1 Rattus norvegicus (Rat) TR30349_c1_g1_i1 Q9NZJ6 COQ3_HUMAN 8.00E-69 GO:0008425; GO:0008689; GO:0008171; GO:0006071; GO:0004395; GO:0005759; GO:0006744 "2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; 3-demethylubiquinone-9 3-O-methyltransferase activity; O-methyltransferase activity; glycerol metabolic process; hexaprenyldihydroxybenzoate methyltransferase activity; mitochondrial matrix; ubiquinone biosynthetic process" IPR013216; IPR010233; Cofactor biosynthesis; ubiquinone biosynthesis. "Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial (EC 2.1.1.114) (2-polyprenyl-6-hydroxyphenol methylase) (EC 2.1.1.222) (3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase) (DHHB methyltransferase) (DHHB-MT) (DHHB-MTase) (3-demethylubiquinone-10 3-methyltransferase) (EC 2.1.1.64) (Dihydroxyhexaprenylbenzoate methyltransferase)" COQ3 UG0215E05 Homo sapiens (Human) TR30349_c1_g1_i2 Q9NZJ6 COQ3_HUMAN 4.00E-70 GO:0008425; GO:0008689; GO:0008171; GO:0006071; GO:0004395; GO:0005759; GO:0006744 "2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; 3-demethylubiquinone-9 3-O-methyltransferase activity; O-methyltransferase activity; glycerol metabolic process; hexaprenyldihydroxybenzoate methyltransferase activity; mitochondrial matrix; ubiquinone biosynthetic process" IPR013216; IPR010233; Cofactor biosynthesis; ubiquinone biosynthesis. "Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial (EC 2.1.1.114) (2-polyprenyl-6-hydroxyphenol methylase) (EC 2.1.1.222) (3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase) (DHHB methyltransferase) (DHHB-MT) (DHHB-MTase) (3-demethylubiquinone-10 3-methyltransferase) (EC 2.1.1.64) (Dihydroxyhexaprenylbenzoate methyltransferase)" COQ3 UG0215E05 Homo sapiens (Human) TR3035_c0_g1_i1 Q9NQP4 PFD4_HUMAN 8.00E-46 GO:0051084; GO:0051087; GO:0005829; GO:0005739; GO:0005634; GO:0016272 'de novo' posttranslational protein folding; chaperone binding; cytosol; mitochondrion; nucleus; prefoldin complex IPR002777; IPR016661; IPR009053; Prefoldin subunit 4 (Protein C-1) PFDN4 PFD4 Homo sapiens (Human) TR30353_c0_g1_i1 P41115 RS11_XENLA 8.00E-76 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR012340; IPR000266; IPR028333; IPR019979; 40S ribosomal protein S11 rps11 Xenopus laevis (African clawed frog) TR30354_c4_g1_i1 Q571H0 NPA1P_MOUSE 2.00E-33 GO:0005730 nucleolus IPR016024; IPR021714; Nucleolar pre-ribosomal-associated protein 1 (URB1 ribosome biogenesis 1 homolog) Urb1 Kiaa0539 Npa1 Mus musculus (Mouse) TR30354_c4_g1_i3 Q571H0 NPA1P_MOUSE 2.00E-07 GO:0005730 nucleolus IPR016024; IPR021714; Nucleolar pre-ribosomal-associated protein 1 (URB1 ribosome biogenesis 1 homolog) Urb1 Kiaa0539 Npa1 Mus musculus (Mouse) TR30355_c1_g1_i1 P35624 TIMP1_PIG 3.00E-06 GO:0043249; GO:0005576; GO:0046872; GO:0008191 erythrocyte maturation; extracellular region; metal ion binding; metalloendopeptidase inhibitor activity IPR001134; IPR001820; IPR008993; IPR015611; IPR027465; Metalloproteinase inhibitor 1 (Tissue inhibitor of metalloproteinases 1) (TIMP-1) TIMP1 Sus scrofa (Pig) TR30355_c1_g1_i2 Q5PXZ9 TIMP3_MACMU 1.00E-08 GO:0046872; GO:0008191; GO:0005578 metal ion binding; metalloendopeptidase inhibitor activity; proteinaceous extracellular matrix IPR001134; IPR001820; IPR008993; IPR027465; IPR015612; Metalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) (TIMP-3) TIMP3 Macaca mulatta (Rhesus macaque) TR30356_c0_g1_i2 B2RXS4 PLXB2_MOUSE 2.00E-06 GO:0007420; GO:0005887; GO:0005622; GO:0001843; GO:0007405; GO:0050772; GO:0032319; GO:0008360; GO:2001222; GO:0001932; GO:0017154 Q68FM7 brain development; integral to plasma membrane; intracellular; neural tube closure; neuroblast proliferation; positive regulation of axonogenesis; regulation of Rho GTPase activity; regulation of cell shape; regulation of neuron migration; regulation of protein phosphorylation; semaphorin receptor activity IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-B2 Plxnb2 Mus musculus (Mouse) TR30356_c1_g2_i1 Q75ZY9 MET_CANFA 4.00E-09 GO:0005524; GO:0000187; GO:0030534; GO:0009925; GO:0007420; GO:0048754; GO:0042593; GO:0005008; GO:0016021; GO:0001889; GO:0014812; GO:0051450; GO:0014902; GO:1901299; GO:0018108; GO:0001890; GO:0010828; GO:0045944; GO:0046777; GO:0060665; GO:0007519 ATP binding; activation of MAPK activity; adult behavior; basal plasma membrane; brain development; branching morphogenesis of an epithelial tube; glucose homeostasis; hepatocyte growth factor-activated receptor activity; integral to membrane; liver development; muscle cell migration; myoblast proliferation; myotube differentiation; negative regulation of hydrogen peroxide-mediated programmed cell death; peptidyl-tyrosine phosphorylation; placenta development; positive regulation of glucose transport; positive regulation of transcription from RNA polymerase II promoter; protein autophosphorylation; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; skeletal muscle tissue development IPR013783; IPR014756; IPR002909; IPR011009; IPR016201; IPR002165; IPR000719; IPR017441; IPR001627; IPR001245; IPR008266; IPR020635; IPR016244; IPR015943; Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) MET Canis familiaris (Dog) (Canis lupus familiaris) TR30359_c0_g1_i2 Q16819 MEP1A_HUMAN 1.00E-21 GO:0007586; GO:0005615; GO:0005887; GO:0017090; GO:0004222; GO:0006508; GO:0008270 P14780 digestion; extracellular space; integral to plasma membrane; meprin A complex; metalloendopeptidase activity; proteolysis; zinc ion binding IPR008985; IPR000742; IPR000998; IPR002083; IPR024079; IPR008294; IPR001506; IPR006026; IPR008974; Meprin A subunit alpha (EC 3.4.24.18) (Endopeptidase-2) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha) (PABA peptide hydrolase) (PPH alpha) MEP1A Homo sapiens (Human) TR30359_c0_g1_i3 Q8QFX6 NRP1A_DANRE 5.00E-13 GO:0001525; GO:0007411; GO:0007155; GO:0035767; GO:0008201; GO:0016021; GO:0046872; GO:0009887; GO:0045765; GO:0017154; GO:0048010; GO:0005021 angiogenesis; axon guidance; cell adhesion; endothelial cell chemotaxis; heparin binding; integral to membrane; metal ion binding; organ morphogenesis; regulation of angiogenesis; semaphorin receptor activity; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor-activated receptor activity IPR000421; IPR008985; IPR000859; IPR008979; IPR000998; IPR014648; IPR022579; IPR027146; Neuropilin-1a (znrp1) nrp1a np-1 nrp1 Danio rerio (Zebrafish) (Brachydanio rerio) TR30359_c1_g1_i1 Q7Z304 MAMC2_HUMAN 9.00E-20 GO:0005783; GO:0005539; GO:0005614; GO:0016020; GO:0019800 endoplasmic reticulum; glycosaminoglycan binding; interstitial matrix; membrane; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IPR008985; IPR000998; MAM domain-containing protein 2 (MAM domain-containing proteoglycan) (Mamcan) MAMDC2 Homo sapiens (Human) TR30360_c0_g1_i1 B3EWR1 LEC_MYTGA 2.00E-102 GO:0005534; GO:0031640 galactose binding; killing of cells of other organism Lectin (MytiLec) Mytilus galloprovincialis (Mediterranean mussel) TR30362_c0_g1_i1 Q8WW62 TMED6_HUMAN 5.00E-21 GO:0005789; GO:0016021; GO:0006810 endoplasmic reticulum membrane; integral to membrane; transport IPR009038; Transmembrane emp24 domain-containing protein 6 (p24 family protein gamma-5) (p24gamma5) TMED6 UNQ9146/PRO34237 Homo sapiens (Human) TR30364_c1_g1_i1 P59723 HIF1N_DANRE 3.00E-12 GO:0046872; GO:0005634; GO:0036140; GO:0042265; GO:0042264; GO:0036139; GO:0036138; GO:0048471; GO:0006355; GO:0006351 "metal ion binding; nucleus; peptidyl-asparagine 3-dioxygenase activity; peptidyl-asparagine hydroxylation; peptidyl-aspartic acid hydroxylation; peptidyl-histidine dioxygenase activity; peptidyl-histidine hydroxylation; perinuclear region of cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR027452; IPR003347; Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30) (EC 1.14.11.n4) (Hypoxia-inducible factor asparagine hydroxylase) hif1an si:rp71-68n3.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR30364_c1_g2_i2 Q497B8 KDM8_RAT 4.00E-91 GO:0000086; GO:0003682; GO:0051864; GO:0046872; GO:0005634; GO:0045893; GO:0006351 "G2/M transition of mitotic cell cycle; chromatin binding; histone demethylase activity (H3-K36 specific); metal ion binding; nucleus; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003347; Lysine-specific demethylase 8 (EC 1.14.11.27) (JmjC domain-containing protein 5) (Jumonji domain-containing protein 5) Kdm8 Jmjd5 Rattus norvegicus (Rat) TR30365_c0_g1_i2 Q5E9R6 CERS4_BOVIN 4.00E-41 GO:0005789; GO:0016021; GO:0006629; GO:0031965; GO:0043565; GO:0003700 endoplasmic reticulum membrane; integral to membrane; lipid metabolic process; nuclear membrane; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR001356; IPR009057; IPR016439; IPR006634; Ceramide synthase 4 (CerS4) (LAG1 longevity assurance homolog 4) CERS4 LASS4 Bos taurus (Bovine) TR30366_c0_g1_i2 Q9D7K2 TEN1L_MOUSE 7.00E-13 GO:0003677; GO:0070188 DNA binding; Stn1-Ten1 complex CST complex subunit TEN1 (Protein telomeric pathways with STN1 homolog) (Telomere length regulation protein TEN1 homolog) Ten1 Mus musculus (Mouse) TR30367_c0_g1_i2 P49256 LMAN2_CANFA 2.00E-104 GO:0000139; GO:0016021; GO:0046872; GO:0015031 Golgi membrane; integral to membrane; metal ion binding; protein transport IPR008985; IPR013320; IPR005052; Vesicular integral-membrane protein VIP36 (Lectin mannose-binding 2) (Vesicular integral-membrane protein 36) (VIP36) LMAN2 Canis familiaris (Dog) (Canis lupus familiaris) TR30369_c0_g2_i1 P59070 PA2SD_AUSSU 4.00E-07 GO:0005509; GO:0005576; GO:0016042; GO:0004623 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity IPR001211; IPR016090; Phospholipase A2 superbin d (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (Fragment) Austrelaps superbus (Lowland copperhead snake) (Hoplocephalus superbus) TR30369_c1_g1_i1 P81458 PA2B_DABRR 1.00E-19 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Basic phospholipase A2 RVV-VD (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (R1) Daboia russelii (Russel's viper) (Vipera russelii) TR30369_c1_g1_i2 Q92086 PA2AC_NAJSP 2.00E-22 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Acidic phospholipase A2 C (svPLA2) (EC 3.1.1.4) (NAJPLA-2C) (APLA) (Phosphatidylcholine 2-acylhydrolase) Naja sputatrix (Malayan spitting cobra) (Naja naja sputatrix) TR30369_c1_g1_i3 Q8AXY1 PA2A_BOTJR 2.00E-19 GO:0005509; GO:0042742; GO:0005576; GO:0016042; GO:0004623; GO:0006644; GO:0008217 calcium ion binding; defense response to bacterium; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process; regulation of blood pressure IPR001211; IPR013090; IPR016090; Acidic phospholipase A2 BthA-1 (svPLA2) (EC 3.1.1.4) (BOJU-III) (BthA-I-PLA2) (Hypotensive phospholipase A2) (Phosphatidylcholine 2-acylhydrolase) Bothrops jararacussu (Jararacussu) TR30370_c3_g1_i1 Q5R890 MINP1_PONAB 1.00E-10 GO:0003993; GO:0034417; GO:0016311; GO:0005788; GO:0052826 acid phosphatase activity; bisphosphoglycerate 3-phosphatase activity; dephosphorylation; endoplasmic reticulum lumen; inositol hexakisphosphate 2-phosphatase activity IPR000560; IPR016274; "Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80) (Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase) (Ins(1,3,4,5)P(4) 3-phosphatase)" MINPP1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR30370_c3_g1_i2 Q9UNW1 MINP1_HUMAN 1.00E-59 GO:0003993; GO:0034417; GO:0030282; GO:0005788; GO:0052826; GO:0043647; GO:0008969; GO:0006797 acid phosphatase activity; bisphosphoglycerate 3-phosphatase activity; bone mineralization; endoplasmic reticulum lumen; inositol hexakisphosphate 2-phosphatase activity; inositol phosphate metabolic process; phosphohistidine phosphatase activity; polyphosphate metabolic process IPR000560; IPR016274; "Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80) (Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase) (Ins(1,3,4,5)P(4) 3-phosphatase)" MINPP1 MIPP UNQ900/PRO1917 Homo sapiens (Human) TR30372_c2_g2_i1 P68943 MED28_RAT 3.00E-31 GO:0030864; GO:0016592; GO:0016020; GO:0051151; GO:0006355; GO:0019827; GO:0006351 "cortical actin cytoskeleton; mediator complex; membrane; negative regulation of smooth muscle cell differentiation; regulation of transcription, DNA-dependent; stem cell maintenance; transcription, DNA-dependent" IPR021640; Mediator of RNA polymerase II transcription subunit 28 (Mediator complex subunit 28) Med28 Rattus norvegicus (Rat) TR30372_c4_g1_i1 Q504G0 TM127_DANRE 7.00E-36 GO:0016021; GO:0005886 integral to membrane; plasma membrane Transmembrane protein 127 tmem127 si:dkey-49h9.5 zgc:109899 Danio rerio (Zebrafish) (Brachydanio rerio) TR30374_c0_g1_i2 Q9CQI4 CK074_MOUSE 2.00E-06 Uncharacterized protein C11orf74 homolog (Protein NWC) Nwc Mus musculus (Mouse) TR30375_c0_g1_i1 Q9CQ40 RM49_MOUSE 1.00E-27 GO:0005761; GO:0003735; GO:0006412 mitochondrial ribosome; structural constituent of ribosome; translation IPR007740; "39S ribosomal protein L49, mitochondrial (L49mt) (MRP-L49)" Mrpl49 Mus musculus (Mouse) TR30376_c2_g1_i1 Q8K0U4 HS12A_MOUSE 5.00E-24 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR30378_c1_g1_i1 P39101 CAJ1_YEAST 2.00E-06 GO:0051087; GO:0005634; GO:0006457 chaperone binding; nucleus; protein folding IPR001623; IPR018253; IPR026894; Protein CAJ1 CAJ1 YER048C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR30378_c1_g1_i2 Q642C0 DNJC8_RAT 2.00E-40 IPR001623; DnaJ homolog subfamily C member 8 Dnajc8 Rattus norvegicus (Rat) TR30379_c0_g4_i1 Q07E02 CAV1_ORNAN 2.00E-25 GO:0000139; GO:0031295; GO:0005901; GO:0005768 Golgi membrane; T cell costimulation; caveola; endosome IPR001612; IPR015504; IPR018361; Caveolin-1 CAV1 Ornithorhynchus anatinus (Duckbill platypus) TR30380_c1_g1_i1 Q5ZLS7 GLYR1_CHICK 1.00E-75 GO:0003677; GO:0050662; GO:0035064; GO:0005634; GO:0006098; GO:0004616 DNA binding; coenzyme binding; methylated histone residue binding; nucleus; pentose-phosphate shunt; phosphogluconate dehydrogenase (decarboxylating) activity IPR008927; IPR006115; IPR017956; IPR013328; IPR015815; IPR016040; IPR000313; Putative oxidoreductase GLYR1 (EC 1.-.-.-) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) GLYR1 NP60 RCJMB04_4p18 Gallus gallus (Chicken) TR30380_c1_g2_i1 Q5XXA9 PSIP1_CHICK 4.00E-10 GO:0001105; GO:0033613; GO:0003682; GO:0000395; GO:0005720; GO:0009408; GO:0006979; GO:0097100; GO:0035327 RNA polymerase II transcription coactivator activity; activating transcription factor binding; chromatin binding; mRNA 5'-splice site recognition; nuclear heterochromatin; response to heat; response to oxidative stress; supercoiled DNA binding; transcriptionally active chromatin IPR017956; IPR021567; IPR000313; Lens epithelium-derived growth factor PSIP1 LEDGF Gallus gallus (Chicken) TR30386_c0_g2_i2 Q95JD5 ST1B1_CANFA 8.00E-32 GO:0004062; GO:0005737; GO:0009812; GO:0008202; GO:0051923; GO:0042403; GO:0006805 aryl sulfotransferase activity; cytoplasm; flavonoid metabolic process; steroid metabolic process; sulfation; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (cSULT1B1) (EC 2.8.2.-) SULT1B1 ST1B2 Canis familiaris (Dog) (Canis lupus familiaris) TR30386_c0_g2_i3 Q3T0Y3 ST1B1_BOVIN 2.00E-25 GO:0004062; GO:0005737; GO:0009812; GO:0008202; GO:0051923; GO:0042403; GO:0006805 aryl sulfotransferase activity; cytoplasm; flavonoid metabolic process; steroid metabolic process; sulfation; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) SULT1B1 Bos taurus (Bovine) TR30387_c0_g1_i1 P38529 HSF1_CHICK 1.00E-87 GO:0005737; GO:0005634; GO:0009408; GO:0043565; GO:0003700; GO:0006351 "cytoplasm; nucleus; response to heat; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR027072; IPR000232; IPR027725; IPR010542; IPR011991; Heat shock factor protein 1 (HSF 1) (HSF 3A) (HSTF 3A) (Heat shock transcription factor 1) (HSTF 1) HSF1 Gallus gallus (Chicken) TR30388_c0_g1_i2 Q62059 CSPG2_MOUSE 2.00E-07 GO:0005509; GO:0030246; GO:0007155; GO:0007507; GO:0005540; GO:0005578; GO:0001657 calcium ion binding; carbohydrate binding; cell adhesion; heart development; hyaluronic acid binding; proteinaceous extracellular matrix; ureteric bud development IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Large fibroblast proteoglycan) (PG-M) Vcan Cspg2 Mus musculus (Mouse) TR30397_c0_g1_i1 Q9X248 FABG_THEMA 4.00E-47 GO:0004316; GO:0051287; GO:0050661; GO:0030497 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NAD binding; NADP binding; fatty acid elongation IPR011284; IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) (Beta-Ketoacyl-acyl carrier protein reductase) (Beta-ketoacyl-ACP reductase) fabG TM_1724 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR30397_c0_g1_i2 P27582 FABG6_BRANA 6.00E-19 GO:0004316; GO:0009507; GO:0006633 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; chloroplast; fatty acid biosynthetic process IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) (Fragments) Brassica napus (Rape) TR30399_c0_g1_i1 Q54IP0 DNJC7_DICDI 3.00E-06 GO:0045335 phagocytic vesicle IPR001623; IPR018253; IPR013026; IPR011990; IPR001440; IPR019734; DnaJ homolog subfamily C member 7 homolog dnajc7 DDB_G0288639 Dictyostelium discoideum (Slime mold) TR30399_c0_g1_i2 P25407 STI1L_PLAFA 5.00E-23 IPR013026; IPR011990; IPR001440; IPR019734; STI1-like protein (Fragment) Plasmodium falciparum TR304_c0_g1_i1 Q66HE7 CDKL1_RAT 2.00E-09 GO:0005524; GO:0004693; GO:0005737; GO:0007507; GO:0005634 ATP binding; cyclin-dependent protein serine/threonine kinase activity; cytoplasm; heart development; nucleus IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase-like 1 (EC 2.7.11.22) Cdkl1 Rattus norvegicus (Rat) TR30400_c0_g1_i1 Q8CJC5 NEUL3_MOUSE 7.00E-06 GO:0016874; GO:0016567; GO:0008270 ligase activity; protein ubiquitination; zinc ion binding IPR006573; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase NEURL3 (EC 6.3.2.-) (Lung-inducible neuralized-related C3CH4 RING domain protein) (Neuralized-like protein 3) Neurl3 Lincr Mus musculus (Mouse) TR30403_c0_g1_i1 P20061 TCO1_HUMAN 4.00E-13 GO:0031419; GO:0009235; GO:0015889; GO:0006824; GO:0005576 cobalamin binding; cobalamin metabolic process; cobalamin transport; cobalt ion transport; extracellular region IPR002157; IPR027954; Transcobalamin-1 (TC-1) (Transcobalamin I) (TC I) (TCI) TCN1 TC1 Homo sapiens (Human) TR30403_c0_g1_i2 Q9XSC9 TCO2_BOVIN 2.00E-14 GO:0031419; GO:0009235; GO:0015889; GO:0006824; GO:0005576; GO:0046872 cobalamin binding; cobalamin metabolic process; cobalamin transport; cobalt ion transport; extracellular region; metal ion binding IPR002157; Transcobalamin-2 (TC-2) (Transcobalamin II) (TC II) (TCII) TCN2 Bos taurus (Bovine) TR30404_c0_g1_i2 Q9NVG8 TBC13_HUMAN 2.00E-156 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; TBC1 domain family member 13 TBC1D13 Homo sapiens (Human) TR30406_c0_g1_i1 A6H791 TRM61_BOVIN 8.00E-86 GO:0005634; GO:0016429; GO:0031515 nucleus; tRNA (adenine-N1-)-methyltransferase activity; tRNA (m1A) methyltransferase complex IPR014816; IPR025809; tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (EC 2.1.1.220) (tRNA(m1A58)-methyltransferase subunit TRMT61A) (tRNA(m1A58)MTase subunit TRMT61A) TRMT61A TRM61 Bos taurus (Bovine) TR30408_c1_g1_i1 Q9BR01 ST4A1_HUMAN 3.00E-24 GO:0050427; GO:0005829; GO:0008202; GO:0008146; GO:0006805 Q13526 3'-phosphoadenosine 5'-phosphosulfate metabolic process; cytosol; steroid metabolic process; sulfotransferase activity; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase 4A1 (ST4A1) (EC 2.8.2.-) (Brain sulfotransferase-like protein) (hBR-STL) (hBR-STL-1) (Nervous system sulfotransferase) (NST) SULT4A1 SULTX3 Homo sapiens (Human) TR30408_c2_g1_i2 Q6IMI6 ST1C3_HUMAN 6.00E-30 GO:0004027; GO:0004062; GO:0005737; GO:0006790 alcohol sulfotransferase activity; aryl sulfotransferase activity; cytoplasm; sulfur compound metabolic process IPR027417; IPR000863; Sulfotransferase 1C3 (ST1C3) (EC 2.8.2.2) SULT1C3 Homo sapiens (Human) TR30408_c2_g1_i3 P52847 ST1B1_RAT 1.00E-32 GO:0004062; GO:0005829; GO:0009812; GO:0008202; GO:0051923; GO:0042403; GO:0006805 aryl sulfotransferase activity; cytosol; flavonoid metabolic process; steroid metabolic process; sulfation; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) (DOPA/tyrosine sulfotransferase) Sult1b1 St1b1 Rattus norvegicus (Rat) TR30408_c2_g1_i5 P63047 ST4A1_RAT 2.00E-41 GO:0005737; GO:0008202; GO:0008146; GO:0006790 cytoplasm; steroid metabolic process; sulfotransferase activity; sulfur compound metabolic process IPR027417; IPR000863; Sulfotransferase 4A1 (ST4A1) (EC 2.8.2.-) (Brain sulfotransferase-like protein) (rBR-STL) (Nervous system sulfotransferase) (NST) Sult4a1 Sultx3 Rattus norvegicus (Rat) TR30410_c2_g1_i1 Q9GV77 FREM2_LYTVA 1.00E-52 GO:0005509; GO:0007154; GO:0007156; GO:0016021; GO:0007275; GO:0005886 calcium ion binding; cell communication; homophilic cell adhesion; integral to membrane; multicellular organismal development; plasma membrane IPR002126; IPR003644; Extracellular matrix protein 3 (FREM2 homolog) ECM3 Lytechinus variegatus (Green sea urchin) (Variegated urchin) TR30410_c4_g4_i2 Q8NEZ2 VP37A_HUMAN 2.00E-29 GO:0000813; GO:0008219; GO:0005813; GO:0016197; GO:0031902; GO:0005634; GO:0015031; GO:0043162; GO:0019082; GO:0019068 ESCRT I complex; cell death; centrosome; endosomal transport; late endosome membrane; nucleus; protein transport; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; viral protein processing; virion assembly IPR009851; IPR016135; Vacuolar protein sorting-associated protein 37A (hVps37A) (ESCRT-I complex subunit VPS37A) (Hepatocellular carcinoma-related protein 1) VPS37A HCRP1 Homo sapiens (Human) TR30410_c6_g1_i1 Q6NVD0 FREM2_MOUSE 6.00E-44 GO:0005604; GO:0005509; GO:0007154; GO:0007156; GO:0048839; GO:0016021; GO:0002009; GO:0005886 basement membrane; calcium ion binding; cell communication; homophilic cell adhesion; inner ear development; integral to membrane; morphogenesis of an epithelium; plasma membrane IPR002126; IPR003644; FRAS1-related extracellular matrix protein 2 (ECM3 homolog) (NV domain-containing protein 1) Frem2 Nv1 Mus musculus (Mouse) TR30412_c1_g1_i1 B0G194 DYM_DICDI 1.00E-17 IPR019142; Dymeclin dym DDB_G0292524 Dictyostelium discoideum (Slime mold) TR30412_c3_g1_i1 Q6DCP6 DYM_XENLA 4.00E-48 GO:0005794 Golgi apparatus IPR019142; Dymeclin dym Xenopus laevis (African clawed frog) TR30413_c4_g3_i1 Q23490 MLT7_CAEEL 5.00E-73 GO:0042338; GO:0020037; GO:0046872; GO:0002119; GO:0018149; GO:0004601; GO:0040032; GO:0006979 cuticle development involved in collagen and cuticulin-based cuticle molting cycle; heme binding; metal ion binding; nematode larval development; peptide cross-linking; peroxidase activity; post-embryonic body morphogenesis; response to oxidative stress IPR010255; IPR002007; IPR019791; IPR003582; Peroxidase mlt-7 (EC 1.11.1.7) (Molting defective protein 7) (MoLT-7) [Cleaved into: Peroxidase mlt-7 light chain; Peroxidase mlt-7 heavy chain] mlt-7 ZK430.8 Caenorhabditis elegans TR30413_c4_g3_i4 Q23490 MLT7_CAEEL 8.00E-70 GO:0042338; GO:0020037; GO:0046872; GO:0002119; GO:0018149; GO:0004601; GO:0040032; GO:0006979 cuticle development involved in collagen and cuticulin-based cuticle molting cycle; heme binding; metal ion binding; nematode larval development; peptide cross-linking; peroxidase activity; post-embryonic body morphogenesis; response to oxidative stress IPR010255; IPR002007; IPR019791; IPR003582; Peroxidase mlt-7 (EC 1.11.1.7) (Molting defective protein 7) (MoLT-7) [Cleaved into: Peroxidase mlt-7 light chain; Peroxidase mlt-7 heavy chain] mlt-7 ZK430.8 Caenorhabditis elegans TR30413_c4_g3_i5 O61213 DUOX1_CAEEL 1.00E-20 GO:0016174; GO:0005509; GO:0042338; GO:0020037; GO:0042744; GO:0016021; GO:0002119; GO:0018149; GO:0004601; GO:0040032; GO:0006979 NAD(P)H oxidase activity; calcium ion binding; cuticle development involved in collagen and cuticulin-based cuticle molting cycle; heme binding; hydrogen peroxide catabolic process; integral to membrane; nematode larval development; peptide cross-linking; peroxidase activity; post-embryonic body morphogenesis; response to oxidative stress IPR011992; IPR002048; IPR013112; IPR017927; IPR013130; IPR013121; IPR010255; IPR002007; IPR019791; IPR017938; Dual oxidase 1 (DUOX1) (EC 1.11.1.-) (EC 1.6.3.1) (Blistered cuticle protein 3) (NADPH thyroid oxidase 1) bli-3 F56C11.1 Caenorhabditis elegans TR30414_c3_g1_i1 Q3V1N1 MFHA1_MOUSE 2.00E-07 IPR001611; IPR025875; IPR003591; IPR027417; IPR020859; Malignant fibrous histiocytoma-amplified sequence 1 homolog Mfhas1 Mus musculus (Mouse) TR30415_c0_g1_i1 Q8VBX0 ASB13_MOUSE 3.00E-68 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 13 (ASB-13) Asb13 Mus musculus (Mouse) TR30417_c0_g1_i1 Q8VZ37 AP3S_ARATH 3.00E-21 GO:0030123; GO:0006897; GO:0010008; GO:0006886; GO:0008565 AP-3 adaptor complex; endocytosis; endosome membrane; intracellular protein transport; protein transporter activity IPR016635; IPR022775; IPR027155; IPR000804; IPR011012; AP-3 complex subunit sigma (AP-3 complex subunit sigma-3) (Adapter-related protein complex 3 sigma subunit) (Sigma-adaptin 3) (Sigma3-adaptin) At3g50860 F18B3.140 Arabidopsis thaliana (Mouse-ear cress) TR30417_c0_g1_i2 Q9WVL1 AP4S1_MOUSE 1.00E-37 GO:0005794; GO:0005905; GO:0006886; GO:0008565; GO:0005802; GO:0016192 Golgi apparatus; coated pit; intracellular protein transport; protein transporter activity; trans-Golgi network; vesicle-mediated transport IPR016635; IPR022775; IPR011012; AP-4 complex subunit sigma-1 (AP-4 adapter complex subunit sigma-1) (Adapter-related protein complex 4 subunit sigma-1) (Sigma-1 subunit of AP-4) (Sigma-4-adaptin) (Sigma4-adaptin) Ap4s1 Mus musculus (Mouse) TR30417_c0_g1_i3 Q9WVL1 AP4S1_MOUSE 2.00E-38 GO:0005794; GO:0005905; GO:0006886; GO:0008565; GO:0005802; GO:0016192 Golgi apparatus; coated pit; intracellular protein transport; protein transporter activity; trans-Golgi network; vesicle-mediated transport IPR016635; IPR022775; IPR011012; AP-4 complex subunit sigma-1 (AP-4 adapter complex subunit sigma-1) (Adapter-related protein complex 4 subunit sigma-1) (Sigma-1 subunit of AP-4) (Sigma-4-adaptin) (Sigma4-adaptin) Ap4s1 Mus musculus (Mouse) TR30417_c0_g1_i4 Q8VZ37 AP3S_ARATH 1.00E-20 GO:0030123; GO:0006897; GO:0010008; GO:0006886; GO:0008565 AP-3 adaptor complex; endocytosis; endosome membrane; intracellular protein transport; protein transporter activity IPR016635; IPR022775; IPR027155; IPR000804; IPR011012; AP-3 complex subunit sigma (AP-3 complex subunit sigma-3) (Adapter-related protein complex 3 sigma subunit) (Sigma-adaptin 3) (Sigma3-adaptin) At3g50860 F18B3.140 Arabidopsis thaliana (Mouse-ear cress) TR30420_c1_g1_i1 Q3T906 GNPTA_HUMAN 8.00E-101 GO:0000139; GO:0003976; GO:0005509; GO:0046835; GO:0030154; GO:0016021; GO:0005634; GO:0009306 Golgi membrane; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; calcium ion binding; carbohydrate phosphorylation; cell differentiation; integral to membrane; nucleus; protein secretion IPR010506; IPR021520; IPR018247; IPR002048; IPR000800; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (EC 2.7.8.17) (GlcNAc-1-phosphotransferase subunits alpha/beta) (Stealth protein GNPTAB) (UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta) [Cleaved into: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta] GNPTAB GNPTA KIAA1208 Homo sapiens (Human) TR30422_c4_g3_i1 Q13263 TIF1B_HUMAN 1.00E-10 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR30426_c0_g1_i1 Q9LDH0 XYLT_ARATH 2.00E-20 GO:0032580; GO:0005797; GO:0000139; GO:0050513; GO:0016021; GO:0031204; GO:0006487 "Golgi cisterna membrane; Golgi medial cisterna; Golgi membrane; glycoprotein 2-beta-D-xylosyltransferase activity; integral to membrane; posttranslational protein targeting to membrane, translocation; protein N-linked glycosylation" IPR007657; Protein modification; protein glycosylation. "Beta-(1,2)-xylosyltransferase (EC 2.4.2.38)" XYLT At5g55500 MTE17.21 Arabidopsis thaliana (Mouse-ear cress) TR30427_c0_g1_i1 Q6PDY2 AEDO_MOUSE 9.00E-38 GO:0047800; GO:0046872; GO:0005739 cysteamine dioxygenase activity; metal ion binding; mitochondrion IPR012864; IPR014710; IPR011051; 2-aminoethanethiol dioxygenase (EC 1.13.11.19) (Cysteamine dioxygenase) Ado Gm237 Mus musculus (Mouse) TR30431_c0_g1_i1 Q3T168 CYBP_BOVIN 2.00E-36 GO:0030877; GO:0005641 beta-catenin destruction complex; nuclear envelope lumen IPR007052; IPR008978; IPR007699; IPR015120; Calcyclin-binding protein (CacyBP) CACYBP Bos taurus (Bovine) TR30435_c1_g3_i1 Q0P6D6 CCD15_HUMAN 6.00E-31 GO:0005813 centrosome Coiled-coil domain-containing protein 15 CCDC15 Homo sapiens (Human) TR30442_c0_g1_i6 Q7ZVE0 GAR1_DANRE 2.00E-45 GO:0003723; GO:0031429; GO:0060216; GO:0001522; GO:0006364 RNA binding; box H/ACA snoRNP complex; definitive hemopoiesis; pseudouridine synthesis; rRNA processing IPR007504; IPR021154; IPR009000; H/ACA ribonucleoprotein complex subunit 1 (Nucleolar protein family A member 1) (snoRNP protein GAR1) gar1 nola1 zgc:56086 Danio rerio (Zebrafish) (Brachydanio rerio) TR30443_c0_g3_i1 Q5ZKJ0 CLP1L_CHICK 2.00E-09 GO:0006915; GO:0016021 apoptotic process; integral to membrane IPR008429; Cleft lip and palate transmembrane protein 1-like protein (CLPTM1-like protein) CLPTM1L RCJMB04_10g15 Gallus gallus (Chicken) TR30443_c0_g4_i1 Q5ZKJ0 CLP1L_CHICK 0 GO:0006915; GO:0016021 apoptotic process; integral to membrane IPR008429; Cleft lip and palate transmembrane protein 1-like protein (CLPTM1-like protein) CLPTM1L RCJMB04_10g15 Gallus gallus (Chicken) TR30444_c2_g2_i1 Q19UN5 CK5P2_PANTR 3.00E-07 GO:0005794; GO:0007420; GO:0051297; GO:0007059; GO:0000132; GO:0005874; GO:0001578; GO:0046600; GO:0022008; GO:0000242; GO:0048471; GO:0045893; GO:0090231; GO:0000922; GO:0044212 "Golgi apparatus; brain development; centrosome organization; chromosome segregation; establishment of mitotic spindle orientation; microtubule; microtubule bundle formation; negative regulation of centriole replication; neurogenesis; pericentriolar material; perinuclear region of cytoplasm; positive regulation of transcription, DNA-dependent; regulation of spindle checkpoint; spindle pole; transcription regulatory region DNA binding" IPR012943; CDK5 regulatory subunit-associated protein 2 CDK5RAP2 Pan troglodytes (Chimpanzee) TR30444_c4_g1_i2 Q5VU43 MYOME_HUMAN 5.00E-09 GO:0005794; GO:0043623; GO:0005813; GO:0019899; GO:0030016; GO:0005634 Golgi apparatus; cellular protein complex assembly; centrosome; enzyme binding; myofibril; nucleus IPR010630; IPR012943; Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) PDE4DIP CMYA2 KIAA0454 KIAA0477 MMGL Homo sapiens (Human) TR30447_c2_g2_i2 Q8CEG5 CC28B_MOUSE 9.00E-23 GO:0005813; GO:0042384; GO:0005737 centrosome; cilium assembly; cytoplasm IPR025271; Coiled-coil domain-containing protein 28B Ccdc28b Mus musculus (Mouse) TR30449_c2_g1_i1 Q8R3V6 CUED1_MOUSE 5.00E-17 IPR003892; IPR009060; CUE domain-containing protein 1 Cuedc1 Mus musculus (Mouse) TR30452_c0_g1_i1 Q78PY7 SND1_MOUSE 0 GO:0016442; GO:0031047; GO:0042470; GO:0005739; GO:0004518; GO:0003676; GO:0090305; GO:0005634; GO:0006355; GO:0006351 "RISC complex; gene silencing by RNA; melanosome; mitochondrion; nuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR016685; IPR016071; IPR002071; IPR002999; Staphylococcal nuclease domain-containing protein 1 (100 kDa coactivator) (p100 co-activator) Snd1 Mus musculus (Mouse) TR30452_c0_g2_i1 Q863B3 SND1_BOVIN 2.00E-48 GO:0016442; GO:0031047; GO:0042470; GO:0005739; GO:0004518; GO:0003676; GO:0090305; GO:0005634; GO:0006355; GO:0006351 "RISC complex; gene silencing by RNA; melanosome; mitochondrion; nuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR016685; IPR016071; IPR002071; IPR002999; Staphylococcal nuclease domain-containing protein 1 (100 kDa coactivator) (p100 co-activator) SND1 Bos taurus (Bovine) TR30455_c2_g1_i1 Q8QFX1 RIMB2_CHICK 1.00E-14 GO:0030054; GO:0010923; GO:0005886; GO:0045202 cell junction; negative regulation of phosphatase activity; plasma membrane; synapse IPR003961; IPR013783; IPR011511; IPR001452; RIMS-binding protein 2 (RIM-BP2) RIMBP2 RBP2 Gallus gallus (Chicken) TR30456_c2_g1_i1 P02552 TBA1_CHICK 1.00E-111 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-1 chain (Fragment) Gallus gallus (Chicken) TR30456_c2_g1_i4 P24635 TBA_OCTVU 4.00E-97 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR003008; Tubulin alpha chain (Fragment) Octopus vulgaris (Common octopus) TR30456_c2_g1_i5 P02553 TBA_LYTPI 9.00E-49 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; Tubulin alpha chain (Fragment) Lytechinus pictus (Painted sea urchin) TR30459_c0_g1_i1 Q9UK61 F208A_HUMAN 3.00E-07 IPR022188; Protein FAM208A (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) FAM208A C3orf63 KIAA1105 Homo sapiens (Human) TR30460_c5_g1_i1 Q9D479 UVSSA_MOUSE 1.00E-50 GO:0000993; GO:0005694; GO:0016567; GO:0009411; GO:0006283 RNA polymerase II core binding; chromosome; protein ubiquitination; response to UV; transcription-coupled nucleotide-excision repair IPR018610; IPR008942; UV-stimulated scaffold protein A Uvssa Kiaa1530 Mus musculus (Mouse) TR30461_c1_g1_i1 P36194 HMGB1_CHICK 2.00E-23 TR30464_c0_g1_i1 O35737 HNRH1_MOUSE 1.00E-26 GO:0003723; GO:0008380; GO:0015629; GO:0071013; GO:0006397; GO:0005654; GO:0000166; GO:0043484 RNA binding; RNA splicing; actin cytoskeleton; catalytic step 2 spliceosome; mRNA processing; nucleoplasm; nucleotide binding; regulation of RNA splicing IPR012677; IPR000504; IPR012996; "Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed]" Hnrnph1 Hnrph Hnrph1 Mus musculus (Mouse) TR30464_c0_g1_i2 Q12849 GRSF1_HUMAN 4.00E-45 GO:0009952; GO:0003729; GO:0006378; GO:0042645; GO:0005739; GO:0016331; GO:0000166; GO:0008033 anterior/posterior pattern specification; mRNA binding; mRNA polyadenylation; mitochondrial nucleoid; mitochondrion; morphogenesis of embryonic epithelium; nucleotide binding; tRNA processing IPR012677; IPR000504; G-rich sequence factor 1 (GRSF-1) GRSF1 Homo sapiens (Human) TR30464_c0_g1_i3 Q9Y4C8 RBM19_HUMAN 2.00E-08 GO:0003723; GO:0005694; GO:0005737; GO:0007275; GO:0005730; GO:0005654; GO:0000166; GO:0040019 RNA binding; chromosome; cytoplasm; multicellular organismal development; nucleolus; nucleoplasm; nucleotide binding; positive regulation of embryonic development IPR012677; IPR000504; Probable RNA-binding protein 19 (RNA-binding motif protein 19) RBM19 KIAA0682 Homo sapiens (Human) TR30464_c0_g1_i5 Q6AY09 HNRH2_RAT 3.00E-77 GO:0003723; GO:0015629; GO:0005737; GO:0005654; GO:0000166; GO:0030529 RNA binding; actin cytoskeleton; cytoplasm; nucleoplasm; nucleotide binding; ribonucleoprotein complex IPR012677; IPR000504; IPR012996; "Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed]" Hnrnph2 Hnrph2 Rattus norvegicus (Rat) TR30466_c1_g1_i1 Q8NCW0 KREM2_HUMAN 2.00E-06 GO:0016055; GO:0016021 Wnt receptor signaling pathway; integral to membrane IPR000859; IPR017076; IPR000001; IPR013806; IPR018056; IPR002889; Kremen protein 2 (Dickkopf receptor 2) (Kringle domain-containing transmembrane protein 2) (Kringle-containing protein marking the eye and the nose) KREMEN2 KRM2 Homo sapiens (Human) TR30467_c0_g1_i1 Q66JG3 SYEM_XENTR 3.00E-142 GO:0005524; GO:0004818; GO:0006424; GO:0005759; GO:0000049 ATP binding; glutamate-tRNA ligase activity; glutamyl-tRNA aminoacylation; mitochondrial matrix; tRNA binding IPR008925; IPR020751; IPR001412; IPR004527; IPR000924; IPR020061; IPR020058; IPR014729; "Probable glutamate--tRNA ligase, mitochondrial (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS)" ears2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30467_c0_g1_i2 B4E6D7 GLUQ_BURCJ 2.00E-26 GO:0005524; GO:0004812; GO:0005737; GO:0043039; GO:0006400; GO:0008270 ATP binding; aminoacyl-tRNA ligase activity; cytoplasm; tRNA aminoacylation; tRNA modification; zinc ion binding IPR022380; IPR000924; IPR020058; IPR014729; Glutamyl-Q tRNA(Asp) synthetase (Glu-Q-RSs) (EC 6.1.1.-) gluQ BceJ2315_23710 BCAL2411 Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)) TR30469_c0_g2_i1 P05450 YAT7_RHOBL 6.00E-08 GO:0030246; GO:0007155 carbohydrate binding; cell adhesion IPR019019; ATP synthase subunits region ORF 7 Rhodopseudomonas blastica TR30470_c1_g1_i2 Q99946 PRRT1_HUMAN 1.00E-09 GO:0030054; GO:0016021; GO:0005886; GO:0009607; GO:0045202 cell junction; integral to membrane; plasma membrane; response to biotic stimulus; synapse IPR007593; Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) PRRT1 C6orf31 NG5 Homo sapiens (Human) TR30474_c0_g1_i1 Q5XGC5 PSMG2_XENTR 2.00E-63 GO:0005634; GO:0043248 nucleus; proteasome assembly IPR019151; IPR016562; Proteasome assembly chaperone 2 psmg2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30474_c0_g1_i2 Q1LXS2 PSMG2_DANRE 6.00E-68 GO:0005634; GO:0043248 nucleus; proteasome assembly IPR019151; IPR016562; Proteasome assembly chaperone 2 (Tumor necrosis factor superfamily member 5-induced protein 1 homolog) psmg2 tnfsf5ip1 si:dkey-263o22.1 wu:fb51b11 zgc:73278 Danio rerio (Zebrafish) (Brachydanio rerio) TR30475_c0_g1_i1 Q90966 RARA_CHICK 2.00E-17 GO:0021575; GO:0005634; GO:0032526; GO:0003708; GO:0043565; GO:0003707; GO:0008270 hindbrain morphogenesis; nucleus; response to retinoic acid; retinoic acid receptor activity; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding IPR008946; IPR000536; IPR003078; IPR001723; IPR001628; IPR013088; Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1) RARA NR1B1 Gallus gallus (Chicken) TR30475_c0_g1_i2 O35507 PPARA_CAVPO 3.00E-09 GO:0008144; GO:0070166; GO:0008544; GO:0006631; GO:0004879; GO:0008289; GO:0032099; GO:0010887; GO:0010871; GO:0010891; GO:0000122; GO:0005634; GO:0046321; GO:0045893; GO:0072366; GO:0072363; GO:0072369; GO:0043565; GO:0003707; GO:0042060; GO:0008270 "drug binding; enamel mineralization; epidermis development; fatty acid metabolic process; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; lipid binding; negative regulation of appetite; negative regulation of cholesterol storage; negative regulation of receptor biosynthetic process; negative regulation of sequestering of triglyceride; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of fatty acid oxidation; positive regulation of transcription, DNA-dependent; regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter; regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter; regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; steroid hormone receptor activity; wound healing; zinc ion binding" IPR003074; IPR003076; IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) PPARA NR1C1 Cavia porcellus (Guinea pig) TR30476_c0_g2_i1 P82670 RT10_BOVIN 3.00E-33 GO:0005739; GO:0005840 mitochondrion; ribosome IPR027486; "28S ribosomal protein S10, mitochondrial (MRP-S10) (S10mt)" MRPS10 Bos taurus (Bovine) TR30480_c0_g1_i2 Q06453 AL_DROME 1.00E-18 GO:0022416; GO:0035015; GO:0007480; GO:0045892; GO:0005634; GO:0045747; GO:0043234; GO:0003700; GO:0000976 P83949 "chaeta development; elongation of arista core; imaginal disc-derived leg morphogenesis; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of Notch signaling pathway; protein complex; sequence-specific DNA binding transcription factor activity; transcription regulatory region sequence-specific DNA binding" IPR017970; IPR001356; IPR009057; IPR000047; IPR003654; Homeobox protein aristaless al CG3935 Drosophila melanogaster (Fruit fly) TR30482_c0_g1_i1 Q9Z1K8 YLAT1_MOUSE 5.00E-30 GO:0015171; GO:0016323; GO:0016021 amino acid transmembrane transporter activity; basolateral plasma membrane; integral to membrane IPR002293; Y+L amino acid transporter 1 (Solute carrier family 7 member 7) (y(+)L-type amino acid transporter 1) (Y+LAT1) (y+LAT-1) Slc7a7 Mus musculus (Mouse) TR30482_c0_g2_i1 P82252 BAT1_RAT 2.00E-28 GO:0016021; GO:0015175; GO:0042605 integral to membrane; neutral amino acid transmembrane transporter activity; peptide antigen binding IPR002293; "B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)" Slc7a9 Bat1 Rattus norvegicus (Rat) TR30482_c1_g1_i2 Q8MH63 LAT1N_HUMAN 5.00E-28 GO:0015171; GO:0016021 amino acid transmembrane transporter activity; integral to membrane IPR002293; Putative L-type amino acid transporter 1-like protein MLAS (hLAT1 3-transmembrane protein MLAS) (hLAT1 3TM MLAS) SLC7A5P1 MLAS Homo sapiens (Human) TR30484_c0_g1_i1 Q4IJM4 CSN5_GIBZE 2.00E-07 GO:0008180; GO:0005737; GO:0046872; GO:0008237; GO:0006508 COP9 signalosome; cytoplasm; metal ion binding; metallopeptidase activity; proteolysis IPR000555; COP9 signalosome complex subunit 5 (EC 3.4.-.-) RRI1 CSN5 FGSG_02584 Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum) TR30484_c0_g1_i2 B5X8M4 BRCC3_SALSA 3.00E-110 GO:0070531; GO:0070552; GO:0031572; GO:0006302; GO:0070537; GO:0046872; GO:0008237; GO:0031593; GO:0045739; GO:0006508; GO:0010212; GO:0004221; GO:0004843 BRCA1-A complex; BRISC complex; G2 DNA damage checkpoint; double-strand break repair; histone H2A K63-linked deubiquitination; metal ion binding; metallopeptidase activity; polyubiquitin binding; positive regulation of DNA repair; proteolysis; response to ionizing radiation; ubiquitin thiolesterase activity; ubiquitin-specific protease activity IPR000555; Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36) brcc3 brcc36 Salmo salar (Atlantic salmon) TR30485_c1_g1_i1 Q6DHR8 NGBR_DANRE 8.00E-50 GO:0005789; GO:0016021; GO:0006486; GO:0002040; GO:0016765 "endoplasmic reticulum membrane; integral to membrane; protein glycosylation; sprouting angiogenesis; transferase activity, transferring alkyl or aryl (other than methyl) groups" IPR001441; Protein modification; protein glycosylation. Nogo-B receptor (NgBR) (Nuclear undecaprenyl pyrophosphate synthase 1 homolog) nus1 ngbr si:ch211-102b16.1 zgc:92136 Danio rerio (Zebrafish) (Brachydanio rerio) TR30486_c0_g1_i2 Q2YDF6 RT35_BOVIN 3.00E-74 GO:0005763 mitochondrial small ribosomal subunit IPR019349; "28S ribosomal protein S35, mitochondrial (MRP-S35) (S35mt) (28S ribosomal protein S28, mitochondrial) (MRP-S28) (S28mt)" MRPS35 MRPS28 Bos taurus (Bovine) TR30487_c0_g1_i1 Q8TEQ8 PIGO_HUMAN 5.00E-27 GO:0006501; GO:0005789; GO:0016021; GO:0016254; GO:0016740 C-terminal protein lipidation; endoplasmic reticulum membrane; integral to membrane; preassembly of GPI anchor in ER membrane; transferase activity IPR017849; IPR017850; IPR002591; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O) PIGO UNQ632/PRO1249 Homo sapiens (Human) TR30489_c0_g1_i1 Q9Z2U1 PSA5_MOUSE 8.00E-150 GO:0005829; GO:0005634; GO:0005839; GO:0019773; GO:0004298; GO:0006511 "cytosol; nucleus; proteasome core complex; proteasome core complex, alpha-subunit complex; threonine-type endopeptidase activity; ubiquitin-dependent protein catabolic process" IPR000426; IPR023332; IPR001353; Proteasome subunit alpha type-5 (EC 3.4.25.1) (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome zeta chain) Psma5 Mus musculus (Mouse) TR30489_c0_g1_i3 A3CW55 PSA_METMJ 3.00E-57 GO:0005737; GO:0019773; GO:0004298; GO:0006511 "cytoplasm; proteasome core complex, alpha-subunit complex; threonine-type endopeptidase activity; ubiquitin-dependent protein catabolic process" IPR019982; IPR000426; IPR023332; IPR001353; Proteasome subunit alpha (EC 3.4.25.1) (20S proteasome alpha subunit) (Proteasome core protein PsmA) psmA Memar_1678 Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) TR30489_c0_g1_i4 O82530 PSA4_PETHY 2.00E-51 GO:0005737; GO:0005634; GO:0019773; GO:0004298; GO:0006511 "cytoplasm; nucleus; proteasome core complex, alpha-subunit complex; threonine-type endopeptidase activity; ubiquitin-dependent protein catabolic process" IPR000426; IPR023332; IPR001353; Proteasome subunit alpha type-4 (EC 3.4.25.1) (20S proteasome alpha subunit C) (20S proteasome subunit alpha-3) PAC1 PRS1 Petunia hybrida (Petunia) TR30493_c0_g1_i1 Q7ZV55 EIF3I_DANRE 1.00E-161 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0006446; GO:0003743 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; regulation of translational initiation; translation initiation factor activity IPR027525; IPR015943; IPR001680; IPR019775; IPR017986; Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (eIF-3-beta) (eIF3 p36) eif3i eif3s2 Danio rerio (Zebrafish) (Brachydanio rerio) TR30494_c0_g1_i1 Q78JE5 FBX22_MOUSE 5.00E-36 GO:0030018; GO:0009267; GO:0005737; GO:0006913; GO:0005634; GO:0032436; GO:2000060; GO:0000209; GO:0010830; GO:0048742 Z disc; cellular response to starvation; cytoplasm; nucleocytoplasmic transport; nucleus; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of myotube differentiation; regulation of skeletal muscle fiber development IPR001810; IPR019494; F-box only protein 22 Fbxo22 Fbx22 Mus musculus (Mouse) TR30495_c0_g1_i1 P22147 XRN1_YEAST 1.00E-101 GO:0004534; GO:0003723; GO:0000932; GO:0005829; GO:0004536; GO:0000741; GO:0005874; GO:0070651; GO:0000956; GO:0000184; GO:0048471; GO:0006364; GO:0007089 P40070 "5'-3' exoribonuclease activity; RNA binding; cytoplasmic mRNA processing body; cytosol; deoxyribonuclease activity; karyogamy; microtubule; nonfunctional rRNA decay; nuclear-transcribed mRNA catabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; perinuclear region of cytoplasm; rRNA processing; traversing start control point of mitotic cell cycle" IPR027073; IPR016494; IPR004859; 5'-3' exoribonuclease 1 (EC 3.1.13.-) (DNA strand transfer protein beta) (STP-beta) (KAR(-)-enhancing mutation protein) (Strand exchange protein 1) (p175) XRN1 DST2 KEM1 RAR5 SEP1 SKI1 YGL173C G1645 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR30495_c1_g1_i1 Q8IZH2 XRN1_HUMAN 6.00E-174 GO:0008409; GO:0003677; GO:0005794; GO:0003723; GO:0000932; GO:0005829; GO:0043928; GO:0010467; GO:0071044; GO:0045111; GO:0071028; GO:0090305; GO:0005886; GO:0016075 5'-3' exonuclease activity; DNA binding; Golgi apparatus; RNA binding; cytoplasmic mRNA processing body; cytosol; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; gene expression; histone mRNA catabolic process; intermediate filament cytoskeleton; nuclear mRNA surveillance; nucleic acid phosphodiester bond hydrolysis; plasma membrane; rRNA catabolic process IPR027073; IPR016494; IPR004859; 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog) XRN1 SEP1 Homo sapiens (Human) TR30496_c0_g2_i1 Q5RBN9 TAD2B_PONAB 3.00E-41 GO:0003677; GO:0003682; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "DNA binding; chromatin binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR009057; IPR001005; IPR017884; IPR016827; IPR000433; Transcriptional adapter 2-beta TADA2B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR30497_c0_g1_i1 P22574 HXB4A_DANRE 1.00E-53 GO:0007275; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017995; IPR001827; IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein Hox-B4a (Hox-B4) (Homeobox protein Zf-13) hoxb4a hox-b4 hoxb4 zf13 Danio rerio (Zebrafish) (Brachydanio rerio) TR30502_c0_g1_i1 P38942 CAT2_CLOK5 2.00E-68 GO:0006084; GO:0016740 acetyl-CoA metabolic process; transferase activity IPR026888; IPR003702; 4-hydroxybutyrate coenzyme A transferase (EC 2.8.3.-) cat2 CKL_3018 Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) TR30503_c0_g1_i1 Q5ZII9 TFP11_CHICK 0 GO:0003677; GO:0008380; GO:0071013; GO:0006397; GO:0016607; GO:0006355; GO:0005681 "DNA binding; RNA splicing; catalytic step 2 spliceosome; mRNA processing; nuclear speck; regulation of transcription, DNA-dependent; spliceosomal complex" IPR000467; IPR022783; IPR024933; IPR022159; Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1) TFIP11 STIP RCJMB04_25m16 Gallus gallus (Chicken) TR30504_c0_g1_i3 Q6DRM0 WRB_DANRE 4.00E-32 GO:0005789; GO:0007507; GO:0016021; GO:0060041 endoplasmic reticulum membrane; heart development; integral to membrane; retina development in camera-type eye Tail-anchored protein insertion receptor WRB (Tryptophan-rich basic protein) (WRB) wrb Danio rerio (Zebrafish) (Brachydanio rerio) TR30506_c1_g1_i1 Q8N302 AGGF1_HUMAN 1.00E-17 GO:0006396; GO:0001525; GO:0007155; GO:0005576; GO:0003676; GO:0048471; GO:0045766; GO:0001938; GO:0001570 RNA processing; angiogenesis; cell adhesion; extracellular region; nucleic acid binding; perinuclear region of cytoplasm; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; vasculogenesis IPR000253; IPR000467; IPR008984; Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) AGGF1 GPATC7 GPATCH7 VG5Q Homo sapiens (Human) TR30506_c1_g1_i2 Q7TN31 AGGF1_MOUSE 4.00E-17 GO:0001525; GO:0007155; GO:0030154; GO:0005576; GO:0003676; GO:0048471; GO:0045766; GO:0001938 angiogenesis; cell adhesion; cell differentiation; extracellular region; nucleic acid binding; perinuclear region of cytoplasm; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation IPR000253; IPR000467; IPR008984; Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (mVG5Q) Aggf1 Vg5q Mus musculus (Mouse) TR30506_c1_g1_i7 Q8N302 AGGF1_HUMAN 2.00E-16 GO:0006396; GO:0001525; GO:0007155; GO:0005576; GO:0003676; GO:0048471; GO:0045766; GO:0001938; GO:0001570 RNA processing; angiogenesis; cell adhesion; extracellular region; nucleic acid binding; perinuclear region of cytoplasm; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; vasculogenesis IPR000253; IPR000467; IPR008984; Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) AGGF1 GPATC7 GPATCH7 VG5Q Homo sapiens (Human) TR30507_c2_g1_i1 P53750 YN93_YEAST 7.00E-07 GO:0004091; GO:0004301; GO:0009636 carboxylesterase activity; epoxide hydrolase activity; response to toxic substance IPR000073; Uncharacterized hydrolase YNR064C (EC 3.1.-.-) YNR064C N3535 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR30508_c3_g1_i1 A2AVA0 SVEP1_MOUSE 5.00E-13 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)" Svep1 Mus musculus (Mouse) TR30509_c0_g1_i2 Q6AYJ3 SPA6L_RAT 1.00E-30 IPR027208; Spermatogenesis associated 6-like protein Spata6l Rattus norvegicus (Rat) TR30510_c0_g1_i1 P61314 RL15_RAT 8.00E-102 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR024794; IPR000439; IPR020925; IPR012678; 60S ribosomal protein L15 Rpl15 Rattus norvegicus (Rat) TR30512_c2_g1_i1 Q6PCF9 S38AA_XENLA 2.00E-24 GO:0006865; GO:0016021; GO:0006814 amino acid transport; integral to membrane; sodium ion transport IPR013057; Putative sodium-coupled neutral amino acid transporter 10 (Solute carrier family 38 member 10) slc38a10 Xenopus laevis (African clawed frog) TR30513_c2_g1_i2 Q32L09 CS066_BOVIN 8.00E-30 IPR026795; UPF0515 protein C19orf66 homolog Bos taurus (Bovine) TR30514_c0_g2_i1 Q0Q028 DFP3_ANTMY 8.00E-11 GO:0042742; GO:0042832; GO:0005576; GO:0045087 defense response to bacterium; defense response to protozoan; extracellular region; innate immune response IPR002861; Putative defense protein 3 (DFP-3) Antheraea mylitta (Tasar silkworm) TR30514_c0_g2_i4 Q765V4 DFP11_SAMCR 1.00E-10 GO:0042742; GO:0042832; GO:0005576; GO:0045087 defense response to bacterium; defense response to protozoan; extracellular region; innate immune response IPR002861; Putative defense protein Hdd11-like Samia ricini (Indian eri silkmoth) (Samia cynthia ricini) TR30515_c1_g1_i1 A8MW92 P20L1_HUMAN 4.00E-37 GO:0008270 P68431; P62805 zinc ion binding IPR022255; IPR002999; IPR014002; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; PHD finger protein 20-like protein 1 PHF20L1 CGI-72 Homo sapiens (Human) TR30515_c2_g3_i1 A2VE56 P20L1_BOVIN 5.00E-33 IPR022255; IPR002999; IPR014002; PHD finger protein 20-like protein 1 PHF20L1 Bos taurus (Bovine) TR30517_c0_g1_i1 Q9BVA6 FICD_HUMAN 1.00E-139 GO:0005524; GO:0016021; GO:0034259; GO:0070733 ATP binding; integral to membrane; negative regulation of Rho GTPase activity; protein adenylyltransferase activity IPR003812; IPR013026; IPR011990; IPR019734; Adenosine monophosphate-protein transferase FICD (EC 2.7.7.n1) (AMPylator FICD) (FIC domain-containing protein) (Huntingtin yeast partner E) (Huntingtin-interacting protein 13) (HIP-13) (Huntingtin-interacting protein E) FICD HIP13 HYPE UNQ3041/PRO9857 Homo sapiens (Human) TR30518_c1_g1_i1 Q5VTH9 WDR78_HUMAN 0 IPR015943; IPR001680; IPR017986; WD repeat-containing protein 78 WDR78 Homo sapiens (Human) TR30519_c1_g1_i1 P25773 CATL1_FELCA 9.00E-09 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR025660; IPR013128; IPR000668; Cathepsin L1 (EC 3.4.22.15) (Cathepsin L) (Progesterone-dependent protein) (PDP) (Fragment) CTSL CTSL1 Felis catus (Cat) (Felis silvestris catus) TR30519_c2_g1_i1 Q26534 CATL_SCHMA 1.00E-37 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L (EC 3.4.22.15) (SMCL1) CL1 Schistosoma mansoni (Blood fluke) TR30519_c2_g2_i1 P32956 CYSP3_CARCN 2.00E-12 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR000169; IPR013128; IPR000668; Cysteine proteinase 3 (EC 3.4.22.-) (CC-III) (Cysteine proteinase III) (Fragment) Carica candamarcensis (Mountain papaya) (Vasconcellea cundinamarcensis) TR30523_c0_g1_i1 P52432 RPAC1_MOUSE 6.00E-177 GO:0003677; GO:0005736; GO:0005666; GO:0003899; GO:0006351 "DNA binding; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase activity; transcription, DNA-dependent" IPR001514; IPR011262; IPR011263; IPR009025; DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPC40) Polr1c Rpo1-1 Mus musculus (Mouse) TR30525_c0_g1_i1 Q96PN8 TSSK3_HUMAN 1.00E-42 GO:0005524; GO:0030154; GO:0000287; GO:0007275; GO:0004674; GO:0007283 ATP binding; cell differentiation; magnesium ion binding; multicellular organismal development; protein serine/threonine kinase activity; spermatogenesis IPR011009; IPR000719; IPR017441; IPR002290; Testis-specific serine/threonine-protein kinase 3 (TSK-3) (TSSK-3) (Testis-specific kinase 3) (EC 2.7.11.1) (Serine/threonine-protein kinase 22C) TSSK3 SPOGA3 STK22C Homo sapiens (Human) TR30525_c0_g1_i2 O54863 TSSK2_MOUSE 7.00E-37 GO:0005524; GO:0001669; GO:0005814; GO:0000287; GO:0007275; GO:0046777; GO:0004674; GO:0007286 ATP binding; acrosomal vesicle; centriole; magnesium ion binding; multicellular organismal development; protein autophosphorylation; protein serine/threonine kinase activity; spermatid development IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (Serine/threonine-protein kinase 22B) Tssk2 Stk22b Mus musculus (Mouse) TR30525_c0_g1_i3 P25333 HAL4_YEAST 4.00E-16 GO:0005524; GO:0000082; GO:0030003; GO:0034613; GO:0006470; GO:0004672; GO:0004674 ATP binding; G1/S transition of mitotic cell cycle; cellular cation homeostasis; cellular protein localization; protein dephosphorylation; protein kinase activity; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase HAL4/SAT4 (EC 2.7.11.1) (Halotolerance protein 4) SAT4 HAL4 YCR008W YCR046 YCR101 YCR8W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR30525_c0_g1_i4 Q641K5 NUAK1_MOUSE 1.00E-33 GO:0005524; GO:0007155; GO:0005737; GO:0005634; GO:0004674; GO:0030155; GO:2000772; GO:0035507; GO:0006974 ATP binding; cell adhesion; cytoplasm; nucleus; protein serine/threonine kinase activity; regulation of cell adhesion; regulation of cellular senescence; regulation of myosin-light-chain-phosphatase activity; response to DNA damage stimulus IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (Omphalocele kinase 1) Nuak1 Kiaa0537 Omphk1 Mus musculus (Mouse) TR30526_c6_g2_i1 Q5R7Y0 BAI2_PONAB 3.00E-28 GO:0004930; GO:0016021; GO:0016525; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; negative regulation of angiogenesis; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR008077; IPR001879; IPR000832; IPR000203; IPR000884; Brain-specific angiogenesis inhibitor 2 BAI2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR30526_c6_g2_i2 A6QLU6 GP133_BOVIN 4.00E-32 GO:0004930; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR008985; IPR013320; IPR017981; IPR000832; IPR017983; IPR000203; Probable G-protein coupled receptor 133 GPR133 Bos taurus (Bovine) TR30526_c6_g3_i1 Q9HAR2 LPHN3_HUMAN 5.00E-38 GO:0004930; GO:0030246; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; carbohydrate binding; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR001879; IPR003924; IPR015630; IPR003334; IPR000832; IPR017983; IPR000203; IPR000922; IPR003112; Latrophilin-3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Lectomedin-3) LPHN3 KIAA0768 LEC3 Homo sapiens (Human) TR30526_c7_g1_i1 P81112 ABA2_CRYAB 4.00E-08 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Snaclec alboaggregin-A subunit alpha' (Alboaggregin-A subunit 2) (AL-A subunit 2) Cryptelytrops albolabris (White-lipped pit viper) (Trimeresurus albolabris) TR30527_c1_g1_i1 Q3SX45 ASB2_BOVIN 2.00E-18 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 2 (ASB-2) ASB2 Bos taurus (Bovine) TR30527_c1_g2_i1 P16157 ANK1_HUMAN 1.00E-19 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR30528_c0_g1_i1 P08574 CY1_HUMAN 5.00E-88 GO:0030054; GO:0045155; GO:0020037; GO:0016021; GO:0005506; GO:0005743; GO:0070469; GO:0022904; GO:0044281 "cell junction; electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity; heme binding; integral to membrane; iron ion binding; mitochondrial inner membrane; respiratory chain; respiratory electron transport chain; small molecule metabolic process" IPR009056; IPR002326; IPR021157; "Cytochrome c1, heme protein, mitochondrial (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1)" CYC1 Homo sapiens (Human) TR30529_c4_g1_i1 Q8IYE0 CC146_HUMAN 1.00E-91 Coiled-coil domain-containing protein 146 CCDC146 KIAA1505 Homo sapiens (Human) TR30530_c0_g1_i1 Q4V832 AP4AT_XENLA 3.00E-31 IPR008942; IPR001026; AP-4 complex accessory subunit tepsin (ENTH domain-containing protein 2) (Tetra-epsin) enthd2 Xenopus laevis (African clawed frog) TR30531_c0_g2_i1 P53597 SUCA_HUMAN 4.00E-143 GO:0003878; GO:0019003; GO:0005525; GO:0048037; GO:0005743; GO:0005759; GO:0005886; GO:0044281; GO:0006105; GO:0004775; GO:0004776; GO:0045244; GO:0006104; GO:0006099 ATP citrate synthase activity; GDP binding; GTP binding; cofactor binding; mitochondrial inner membrane; mitochondrial matrix; plasma membrane; small molecule metabolic process; succinate metabolic process; succinate-CoA ligase (ADP-forming) activity; succinate-CoA ligase (GDP-forming) activity; succinate-CoA ligase complex (GDP-forming); succinyl-CoA metabolic process; tricarboxylic acid cycle IPR017440; IPR003781; IPR005810; IPR005811; IPR016040; IPR016102; Carbohydrate metabolism; tricarboxylic acid cycle. "Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)" SUCLG1 Homo sapiens (Human) TR30535_c1_g1_i1 Q8NBL1 PGLT1_HUMAN 2.00E-23 GO:0007219; GO:0035251; GO:0035252; GO:0072358; GO:0005788; GO:0006493; GO:0008593 Notch signaling pathway; UDP-glucosyltransferase activity; UDP-xylosyltransferase activity; cardiovascular system development; endoplasmic reticulum lumen; protein O-linked glycosylation; regulation of Notch signaling pathway IPR006598; Protein modification; protein glycosylation. Protein O-glucosyltransferase 1 (EC 2.4.1.-) (CAP10-like 46 kDa protein) (hCLP46) (KTEL motif-containing protein 1) (Myelodysplastic syndromes relative protein) POGLUT1 C3orf9 CLP46 KTELC1 MDSRP MDS010 UNQ490/PRO1006 Homo sapiens (Human) TR30535_c2_g1_i1 Q7ZVE6 KDEL1_DANRE 6.00E-113 GO:0005788 endoplasmic reticulum lumen IPR001298; IPR017868; IPR013783; IPR014756; IPR006598; KDEL motif-containing protein 1 kdelc1 si:dkey-22a1.1 zgc:56065 Danio rerio (Zebrafish) (Brachydanio rerio) TR30536_c0_g1_i1 Q6GM07 CINP_XENLA 1.00E-33 GO:0006281; GO:0006260; GO:0007049; GO:0051301; GO:0005634 DNA repair; DNA replication; cell cycle; cell division; nucleus IPR023250; Cyclin-dependent kinase 2-interacting protein cinp Xenopus laevis (African clawed frog) TR30536_c0_g1_i3 Q6GM07 CINP_XENLA 2.00E-33 GO:0006281; GO:0006260; GO:0007049; GO:0051301; GO:0005634 DNA repair; DNA replication; cell cycle; cell division; nucleus IPR023250; Cyclin-dependent kinase 2-interacting protein cinp Xenopus laevis (African clawed frog) TR30537_c2_g1_i2 Q5UR67 YR617_MIMIV 4.00E-18 IPR012816; Uncharacterized protein R617 MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) TR30539_c1_g1_i1 Q866E8 FUT1_CEBAP 2.00E-22 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" FUT1 Cebus apella (Brown-capped capuchin) TR30539_c1_g1_i2 Q9TUD6 FUT1_PANTR 4.00E-24 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" FUT1 Pan troglodytes (Chimpanzee) TR30540_c0_g1_i1 Q55DB6 AHSA_DICDI 2.00E-49 GO:0001671; GO:0005737; GO:0032781; GO:0006950 ATPase activator activity; cytoplasm; positive regulation of ATPase activity; response to stress IPR013538; IPR015310; IPR023393; Activator of 90 kDa heat shock protein ATPase homolog ahsa aha1 DDB_G0269712 Dictyostelium discoideum (Slime mold) TR30540_c0_g1_i2 O95433 AHSA1_HUMAN 2.00E-96 GO:0001671; GO:0051087; GO:0005737; GO:0005829; GO:0005783; GO:0006457; GO:0006950 P30793; P07900 ATPase activator activity; chaperone binding; cytoplasm; cytosol; endoplasmic reticulum; protein folding; response to stress IPR013538; IPR015310; IPR023393; Activator of 90 kDa heat shock protein ATPase homolog 1 (AHA1) (p38) AHSA1 C14orf3 HSPC322 Homo sapiens (Human) TR30541_c0_g1_i1 B2GUN4 MARF1_XENTR 3.00E-63 GO:0003723; GO:0000166; GO:0048477; GO:0005777; GO:0010468 RNA binding; nucleotide binding; oogenesis; peroxisome; regulation of gene expression IPR024582; IPR024768; IPR012677; IPR021139; IPR025605; IPR000504; Meiosis arrest female protein 1 homolog (Limkain-b1) marf1 lkap Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30541_c7_g1_i1 E1BZ85 MARF1_CHICK 2.00E-35 GO:0003723; GO:0010923; GO:0000166; GO:0048477; GO:0005777; GO:0010468 RNA binding; negative regulation of phosphatase activity; nucleotide binding; oogenesis; peroxisome; regulation of gene expression IPR024582; IPR024768; IPR012677; IPR021139; IPR025605; IPR000504; Meiosis arrest female protein 1 homolog (Limkain-b1) MARF1 LKAP Gallus gallus (Chicken) TR30542_c0_g1_i1 F6U5F9 INTU_XENTR 1.00E-35 GO:0009986; GO:0042384; GO:0005737; GO:0060173; GO:0007399; GO:0008589 cell surface; cilium assembly; cytoplasm; limb development; nervous system development; regulation of smoothened signaling pathway IPR001478; Protein inturned (Inturned planar cell polarity effector homolog) intu Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30542_c0_g1_i2 Q9ULD6 INTU_HUMAN 5.00E-45 GO:0009986; GO:0042384; GO:0005737; GO:0060173; GO:0007399; GO:0008589; GO:0021513 cell surface; cilium assembly; cytoplasm; limb development; nervous system development; regulation of smoothened signaling pathway; spinal cord dorsal/ventral patterning IPR001478; Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6) INTU KIAA1284 PDZD6 PDZK6 Homo sapiens (Human) TR30544_c5_g2_i1 Q8IWE5 PKHM2_HUMAN 3.00E-69 GO:0007030; GO:0005737; GO:0019894; GO:0005543 Golgi organization; cytoplasm; kinesin binding; phospholipid binding IPR011993; IPR001849; IPR004012; Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein) PLEKHM2 KIAA0842 SKIP Homo sapiens (Human) TR30546_c0_g2_i1 Q9VXG8 ATR_DROME 4.00E-14 GO:0005524; GO:0003677; GO:0007015; GO:0007349; GO:0030261; GO:0045002; GO:0045003; GO:0001700; GO:0016321; GO:0007444; GO:0000706; GO:0033314; GO:0007095; GO:0005634; GO:0048477; GO:0004672; GO:0004674; GO:0007131; GO:0008360; GO:0007088; GO:0007348; GO:0009314; GO:0000723 ATP binding; DNA binding; actin filament organization; cellularization; chromosome condensation; double-strand break repair via single-strand annealing; double-strand break repair via synthesis-dependent strand annealing; embryonic development via the syncytial blastoderm; female meiosis chromosome segregation; imaginal disc development; meiotic DNA double-strand break processing; mitotic DNA replication checkpoint; mitotic G2 DNA damage checkpoint; nucleus; oogenesis; protein kinase activity; protein serine/threonine kinase activity; reciprocal meiotic recombination; regulation of cell shape; regulation of mitosis; regulation of syncytial blastoderm mitotic cell cycle; response to radiation; telomere maintenance IPR016024; IPR003152; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR011990; IPR012993; Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein homolog) (ATR homolog) (dATR) (Meiotic protein 41) mei-41 CG4252 Drosophila melanogaster (Fruit fly) TR30546_c1_g1_i1 Q54ER4 ATR1_DICDI 1.00E-14 GO:0005524; GO:0006281; GO:0000075; GO:0005634; GO:0004672; GO:0004674 ATP binding; DNA repair; cell cycle checkpoint; nucleus; protein kinase activity; protein serine/threonine kinase activity IPR016024; IPR003152; IPR011009; IPR000403; IPR003151; IPR014009; IPR012993; Probable serine/threonine-protein kinase atr1 (EC 2.7.11.1) (Ataxia telangiectasia and rad3 related protein 1) atr1 DDB_G0291380 Dictyostelium discoideum (Slime mold) TR30546_c1_g2_i1 Q9DE14 ATR_XENLA 9.00E-39 GO:0005524; GO:0003677; GO:0006281; GO:0005634; GO:0018105; GO:0004674 ATP binding; DNA binding; DNA repair; nucleus; peptidyl-serine phosphorylation; protein serine/threonine kinase activity IPR011989; IPR016024; IPR003152; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR011990; IPR012993; Serine/threonine-protein kinase atr (Xatr) (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) atr Xenopus laevis (African clawed frog) TR30546_c1_g3_i1 Q02099 RAD3_SCHPO 4.00E-16 GO:0005524; GO:0006281; GO:0006260; GO:0005829; GO:0031573; GO:0007095; GO:0000228; GO:0043234; GO:0004674 P87074 ATP binding; DNA repair; DNA replication; cytosol; intra-S DNA damage checkpoint; mitotic G2 DNA damage checkpoint; nuclear chromosome; protein complex; protein serine/threonine kinase activity IPR003152; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR011990; IPR012993; Protein kinase rad3 (EC 2.7.11.1) (DNA repair protein rad3) rad3 SPBC216.05 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR30546_c3_g1_i1 Q9DE14 ATR_XENLA 1.00E-164 GO:0005524; GO:0003677; GO:0006281; GO:0005634; GO:0018105; GO:0004674 ATP binding; DNA binding; DNA repair; nucleus; peptidyl-serine phosphorylation; protein serine/threonine kinase activity IPR011989; IPR016024; IPR003152; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR011990; IPR012993; Serine/threonine-protein kinase atr (Xatr) (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) atr Xenopus laevis (African clawed frog) TR30549_c0_g1_i1 Q9CA40 NUDT1_ARATH 3.00E-24 GO:0008413; GO:0000210; GO:0005829; GO:0019177; GO:0046872; GO:0006974 "8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity; NAD+ diphosphatase activity; cytosol; dihydroneopterin triphosphate pyrophosphohydrolase activity; metal ion binding; response to DNA damage stimulus" IPR020476; IPR020084; IPR000086; IPR015797; "Nudix hydrolase 1 (AtNUDT1) (EC 3.6.1.-) (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTP diphosphatase) (8-oxo-dGTPase) (EC 3.6.1.55) (Dihydroneopterin triphosphate pyrophosphohydrolase) (DHNTP pyrophosphohydrolase) (NADH pyrophosphatase) (EC 3.6.1.22)" NUDT1 NUDX1 At1g68760 F14K14.13 Arabidopsis thaliana (Mouse-ear cress) TR30549_c0_g1_i2 Q8BG93 NUD15_MOUSE 2.00E-37 GO:0035539; GO:0008413; GO:0006184; GO:0006203; GO:0046872; GO:0000302 "8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity; GTP catabolic process; dGTP catabolic process; metal ion binding; response to reactive oxygen species" IPR020476; IPR020084; IPR000086; IPR015797; "Probable 8-oxo-dGTP diphosphatase NUDT15 (8-oxo-dGTPase NUDT15) (EC 3.6.1.55) (7,8-dihydro-8-oxoguanine-triphosphatase NUDT15) (MutT homolog 2) (mMTH2) (Nucleoside diphosphate-linked moiety X motif 15) (Nudix motif 15)" Nudt15 Mth2 Mus musculus (Mouse) TR30549_c1_g1_i2 Q8BG93 NUD15_MOUSE 3.00E-46 GO:0035539; GO:0008413; GO:0006184; GO:0006203; GO:0046872; GO:0000302 "8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity; GTP catabolic process; dGTP catabolic process; metal ion binding; response to reactive oxygen species" IPR020476; IPR020084; IPR000086; IPR015797; "Probable 8-oxo-dGTP diphosphatase NUDT15 (8-oxo-dGTPase NUDT15) (EC 3.6.1.55) (7,8-dihydro-8-oxoguanine-triphosphatase NUDT15) (MutT homolog 2) (mMTH2) (Nucleoside diphosphate-linked moiety X motif 15) (Nudix motif 15)" Nudt15 Mth2 Mus musculus (Mouse) TR30551_c0_g1_i1 P05934 CALM_STRPU 1.00E-24 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) (Fragment) Strongylocentrotus purpuratus (Purple sea urchin) TR30551_c0_g1_i2 Q5U206 CALL3_RAT 4.00E-57 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-like protein 3 Calml3 Rattus norvegicus (Rat) TR30552_c1_g1_i1 Q3UES3 TNKS2_MOUSE 3.00E-12 GO:0000139; GO:0003950; GO:0016055; GO:0000781; GO:0046872; GO:0035264; GO:0005635; GO:0000242; GO:0048471; GO:0090263; GO:0070213; GO:0070198; GO:0000209; GO:0040014; GO:0000723 "Golgi membrane; NAD+ ADP-ribosyltransferase activity; Wnt receptor signaling pathway; chromosome, telomeric region; metal ion binding; multicellular organism growth; nuclear envelope; pericentriolar material; perinuclear region of cytoplasm; positive regulation of canonical Wnt receptor signaling pathway; protein auto-ADP-ribosylation; protein localization to chromosome, telomeric region; protein polyubiquitination; regulation of multicellular organism growth; telomere maintenance" IPR002110; IPR020683; IPR012317; IPR001660; IPR013761; IPR011510; Tankyrase-2 (TANK2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) Tnks2 Tank2 Mus musculus (Mouse) TR30552_c4_g2_i1 Q9HCD6 TANC2_HUMAN 8.00E-17 GO:0001701 in utero embryonic development IPR002110; IPR020683; IPR027417; IPR013026; IPR011990; IPR019734; "Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2)" TANC2 KIAA1148 KIAA1636 Homo sapiens (Human) TR30553_c1_g1_i1 P34488 YMJC_CAEEL 2.00E-09 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR019427; IPR000276; IPR017452; Putative G-protein coupled receptor F59B2.13 F59B2.13 Caenorhabditis elegans TR30555_c0_g1_i1 Q3MHY7 RM10_BOVIN 3.00E-28 GO:0005762; GO:0042254; GO:0003735; GO:0006412 mitochondrial large ribosomal subunit; ribosome biogenesis; structural constituent of ribosome; translation IPR001790; "39S ribosomal protein L10, mitochondrial (L10mt) (MRP-L10)" MRPL10 Bos taurus (Bovine) TR30555_c0_g1_i2 Q5FTX5 RL10_GLUOX 4.00E-09 GO:0070180; GO:0005840; GO:0042254; GO:0006412 LSU rRNA binding; ribosome; ribosome biogenesis; translation IPR022973; IPR001790; 50S ribosomal protein L10 rplJ GOX0388 Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans) TR30558_c0_g1_i1 A8WGS4 TLCD2_DANRE 5.00E-31 GO:0016021 integral to membrane IPR006634; TLC domain-containing protein 2 tlcd2 zgc:175098 Danio rerio (Zebrafish) (Brachydanio rerio) TR30560_c0_g2_i2 A2AKY4 Z804A_MOUSE 1.00E-08 GO:0046872 metal ion binding IPR007087; IPR015880; IPR022755; Zinc finger protein 804A Znf804a Zfp804a Mus musculus (Mouse) TR30561_c0_g1_i1 Q5E9Z7 RPC4_BOVIN 2.00E-33 GO:0003677; GO:0005666; GO:0003899; GO:0051607; GO:0045087; GO:0045089; GO:0032728; GO:0006383 DNA binding; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase activity; defense response to virus; innate immune response; positive regulation of innate immune response; positive regulation of interferon-beta production; transcription from RNA polymerase III promoter IPR007811; DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) POLR3D Bos taurus (Bovine) TR30562_c2_g2_i1 P01130 LDLR_HUMAN 8.00E-07 GO:0005794; GO:0005509; GO:0042632; GO:0070508; GO:0008203; GO:0030669; GO:0005905; GO:0005769; GO:0010008; GO:0009897; GO:0005887; GO:0030299; GO:0005770; GO:0042159; GO:0042157; GO:0034362; GO:0030169; GO:0034383; GO:0005041; GO:0005764; GO:0019048; GO:0015914; GO:0007603; GO:0010867; GO:0010899; GO:0001523; GO:0044281; GO:0030229 Q8NBP7 "Golgi apparatus; calcium ion binding; cholesterol homeostasis; cholesterol import; cholesterol metabolic process; clathrin-coated endocytic vesicle membrane; coated pit; early endosome; endosome membrane; external side of plasma membrane; integral to plasma membrane; intestinal cholesterol absorption; late endosome; lipoprotein catabolic process; lipoprotein metabolic process; low-density lipoprotein particle; low-density lipoprotein particle binding; low-density lipoprotein particle clearance; low-density lipoprotein receptor activity; lysosome; modulation by virus of host morphology or physiology; phospholipid transport; phototransduction, visible light; positive regulation of triglyceride biosynthetic process; regulation of phosphatidylcholine catabolic process; retinoid metabolic process; small molecule metabolic process; very-low-density lipoprotein particle receptor activity" IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor (LDL receptor) LDLR Homo sapiens (Human) TR30562_c2_g2_i2 O75581 LRP6_HUMAN 2.00E-07 GO:0044332; GO:0021874; GO:0090244; GO:0042813; GO:0034185; GO:0090245; GO:0060349; GO:0046849; GO:0060444; GO:0061310; GO:0044335; GO:0061324; GO:0044340; GO:0042074; GO:0009986; GO:0071397; GO:0021587; GO:0021795; GO:0021987; GO:0060026; GO:0071936; GO:0031410; GO:0071542; GO:0005769; GO:0048596; GO:0042733; GO:0035115; GO:0035116; GO:0030326; GO:0009880; GO:0060059; GO:0005783; GO:0035261; GO:0060325; GO:0021861; GO:0021943; GO:0001947; GO:0016021; GO:0019210; GO:0005041; GO:0060596; GO:0030901; GO:0030917; GO:0050680; GO:0045599; GO:2000151; GO:2000162; GO:2000168; GO:2000164; GO:2000166; GO:2000149; GO:0071901; GO:0034392; GO:0014029; GO:0001843; GO:0043025; GO:0042475; GO:0060021; GO:0003344; GO:0005886; GO:2000055; GO:0043065; GO:0045780; GO:0090263; GO:0045787; GO:0002053; GO:0045778; GO:0051091; GO:0045944; GO:0036342; GO:0090009; GO:0043235; GO:0090118; GO:0060284; GO:0045598; GO:0030278; GO:0051593; GO:0045202; GO:0007268; GO:0021794; GO:0019534; GO:0060535 Q9Y4X0; Q9H6X2; O70239; Q03135; P98082; P49840; P49841; Q5S007; Q9ERE8 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt receptor signaling pathway involved in forebrain neuroblast division; Wnt receptor signaling pathway involved in somitogenesis; Wnt-activated receptor activity; apolipoprotein binding; axis elongation involved in somitogenesis; bone morphogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development; canonical Wnt receptor signaling pathway involved in neural crest cell differentiation; canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; canonical Wnt receptor signaling pathway involved in regulation of cell proliferation; cell migration involved in gastrulation; cell surface; cellular response to cholesterol; cerebellum morphogenesis; cerebral cortex cell migration; cerebral cortex development; convergent extension; coreceptor activity involved in Wnt receptor signaling pathway; cytoplasmic vesicle; dopaminergic neuron differentiation; early endosome; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; embryonic pattern specification; embryonic retina morphogenesis in camera-type eye; endoplasmic reticulum; external genitalia morphogenesis; face morphogenesis; forebrain radial glial cell differentiation; formation of radial glial scaffolds; heart looping; integral to membrane; kinase inhibitor activity; low-density lipoprotein receptor activity; mammary placode formation; midbrain development; midbrain-hindbrain boundary development; negative regulation of epithelial cell proliferation; negative regulation of fat cell differentiation; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis; negative regulation of planar cell polarity pathway involved in neural tube closure; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest formation; neural tube closure; neuronal cell body; odontogenesis of dentin-containing tooth; palate development; pericardium morphogenesis; plasma membrane; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell cycle; positive regulation of mesenchymal cell proliferation; positive regulation of ossification; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; post-anal tail morphogenesis; primitive streak formation; receptor complex; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport; regulation of cell development; regulation of fat cell differentiation; regulation of ossification; response to folic acid; synapse; synaptic transmission; thalamus development; toxin transporter activity; trachea cartilage morphogenesis IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 6 (LRP-6) LRP6 Homo sapiens (Human) TR30562_c2_g2_i3 A2ARV4 LRP2_MOUSE 2.00E-07 GO:0005794; GO:0016324; GO:0031526; GO:0005509; GO:0008283; GO:0005905; GO:0030139; GO:0005783; GO:0005768; GO:0030900; GO:0016021; GO:0004872; GO:0006898; GO:0006766 P97318; Q62108; Q9Z0G0; Q9WVI9; Q9ERE9; Q9D6K5 Golgi apparatus; apical plasma membrane; brush border membrane; calcium ion binding; cell proliferation; coated pit; endocytic vesicle; endoplasmic reticulum; endosome; forebrain development; integral to membrane; receptor activity; receptor-mediated endocytosis; vitamin metabolic process IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) Lrp2 Mus musculus (Mouse) TR30562_c2_g2_i4 Q05793 PGBM_MOUSE 6.00E-07 GO:0005796; GO:0001525; GO:0005605; GO:0007420; GO:0048738; GO:0060351; GO:0002062; GO:0048704; GO:0001958; GO:0030198; GO:0046872; GO:0008104 Golgi lumen; angiogenesis; basal lamina; brain development; cardiac muscle tissue development; cartilage development involved in endochondral bone morphogenesis; chondrocyte differentiation; embryonic skeletal system morphogenesis; endochondral ossification; extracellular matrix organization; metal ion binding; protein localization IPR008985; IPR013320; IPR000742; IPR013032; IPR002049; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR018031; IPR000034; IPR001791; IPR023415; IPR002172; IPR000082; Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) [Cleaved into: Endorepellin; LG3 peptide] Hspg2 Mus musculus (Mouse) TR30565_c2_g3_i1 Q5U249 ELYS_XENLA 2.00E-08 GO:0003677; GO:0051028; GO:0005643; GO:0015031 DNA binding; mRNA transport; nuclear pore; protein transport IPR017956; IPR025151; IPR011047; IPR001680; Protein ELYS (Protein MEL-28) (xELYS) ahctf1 elys Xenopus laevis (African clawed frog) TR30567_c0_g1_i1 Q9Y2X8 UB2D4_HUMAN 1.00E-34 GO:0005524; GO:0070979; GO:0044314; GO:0035519; GO:0070936; GO:0085020; GO:0070534; GO:0004842 Q86UW9; Q9Y3C5; Q9BV68; Q8ND25 ATP binding; protein K11-linked ubiquitination; protein K27-linked ubiquitination; protein K29-linked ubiquitination; protein K48-linked ubiquitination; protein K6-linked ubiquitination; protein K63-linked ubiquitination; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 D4 (EC 6.3.2.19) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4) UBE2D4 UBCH5D Homo sapiens (Human) TR30568_c6_g1_i1 Q04841 3MG_MOUSE 4.00E-52 GO:0003677; GO:0008725; GO:0052822; GO:0052821; GO:0043916; GO:0003905; GO:0006284; GO:0005634 DNA binding; DNA-3-methyladenine glycosylase activity; DNA-3-methylguanine glycosylase activity; DNA-7-methyladenine glycosylase activity; DNA-7-methylguanine glycosylase activity; alkylbase DNA N-glycosylase activity; base-excision repair; nucleus IPR011034; IPR003180; DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) Mpg Mid1 Mus musculus (Mouse) TR30568_c6_g1_i2 Q1RJJ3 3MGH_RICBR 2.00E-08 GO:0003677; GO:0003905; GO:0006284 DNA binding; alkylbase DNA N-glycosylase activity; base-excision repair IPR011034; IPR003180; IPR022438; Putative 3-methyladenine DNA glycosylase (EC 3.2.2.-) RBE_0390 Rickettsia bellii (strain RML369-C) TR30568_c6_g1_i3 P29372 3MG_HUMAN 2.00E-30 GO:0006307; GO:0008725; GO:0052822; GO:0052821; GO:0043916; GO:0003684; GO:0045007; GO:0005654 P04156 DNA dealkylation involved in DNA repair; DNA-3-methyladenine glycosylase activity; DNA-3-methylguanine glycosylase activity; DNA-7-methyladenine glycosylase activity; DNA-7-methylguanine glycosylase activity; damaged DNA binding; depurination; nucleoplasm IPR011034; IPR003180; DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) MPG AAG ANPG MID1 Homo sapiens (Human) TR30569_c0_g1_i1 P83425 HIP_MYTED 2.00E-08 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR30574_c0_g2_i4 A2ARA8 ITA8_MOUSE 4.00E-08 GO:0045177; GO:0007155; GO:0030030; GO:0045184; GO:0030198; GO:0042472; GO:0008305; GO:0007229; GO:0007613; GO:0046872; GO:0001656; GO:0007399; GO:2000721; GO:0030511; GO:0048745 apical part of cell; cell adhesion; cell projection organization; establishment of protein localization; extracellular matrix organization; inner ear morphogenesis; integrin complex; integrin-mediated signaling pathway; memory; metal ion binding; metanephros development; nervous system development; positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; positive regulation of transforming growth factor beta receptor signaling pathway; smooth muscle tissue development IPR013517; IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] Itga8 Mus musculus (Mouse) TR30575_c0_g2_i1 Q28362 SL9A3_DIDVI 2.00E-37 GO:0030165; GO:0016324; GO:0031526; GO:0016021; GO:0006885; GO:0015385 Q6P0Q8 PDZ domain binding; apical plasma membrane; brush border membrane; integral to membrane; regulation of pH; sodium:hydrogen antiporter activity IPR006153; IPR018422; IPR018410; IPR004709; Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3) SLC9A3 NHE3 Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) TR30575_c2_g1_i1 P48762 SL9A1_PIG 7.00E-33 GO:0048306; GO:0071468; GO:0005783; GO:0005789; GO:0016021; GO:0005886; GO:0051259; GO:0051453; GO:0001101; GO:0071436; GO:0015385 calcium-dependent protein binding; cellular response to acidity; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; plasma membrane; protein oligomerization; regulation of intracellular pH; response to acid; sodium ion export; sodium:hydrogen antiporter activity IPR006153; IPR018422; IPR001970; IPR004709; Sodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) SLC9A1 NHE1 Sus scrofa (Pig) TR30576_c2_g1_i1 Q9WYX8 Y508_THEMA 3.00E-27 GO:0005524; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0009378 ATP binding; DNA binding; DNA recombination; DNA repair; DNA replication; four-way junction helicase activity IPR003593; IPR008824; IPR008921; IPR002589; IPR021886; IPR027417; Uncharacterized protein TM_0508 TM_0508 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR30576_c2_g1_i3 Q80V91 DTX3_MOUSE 4.00E-45 GO:0007219; GO:0005737; GO:0016874; GO:0016567; GO:0008270 Notch signaling pathway; cytoplasm; ligase activity; protein ubiquitination; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase DTX3 (EC 6.3.2.-) (Protein deltex-3) (Deltex3) (mDTX3) Dtx3 Mus musculus (Mouse) TR30578_c0_g1_i2 P42029 NDUA8_BOVIN 1.00E-33 GO:0005758; GO:0005747; GO:0055114 mitochondrial intermembrane space; mitochondrial respiratory chain complex I; oxidation-reduction process IPR010625; IPR016680; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (Complex I-PGIV) (CI-PGIV) (NADH-ubiquinone oxidoreductase 19 kDa subunit) NDUFA8 Bos taurus (Bovine) TR30579_c6_g1_i2 Q9SE95 FIP2_ARATH 3.00E-17 GO:0051260; GO:0016567 protein homooligomerization; protein ubiquitination IPR001646; IPR000210; IPR011333; IPR003131; Protein modification; protein ubiquitination. FH protein interacting protein FIP2 (BTB/POZ domain-containing protein At5g55000) FIP2 At5g55000 MBG8.27 Arabidopsis thaliana (Mouse-ear cress) TR30581_c0_g2_i1 Q86NP2 NELFA_DROME 1.00E-75 GO:0032021; GO:0003723; GO:0005694; GO:0007275; GO:0034244; GO:0007070; GO:0006351; GO:0017053 "NELF complex; RNA binding; chromosome; multicellular organismal development; negative regulation of transcription elongation from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter during mitosis; transcription, DNA-dependent; transcriptional repressor complex" IPR026305; Negative elongation factor A Nelf-A CG5874 Drosophila melanogaster (Fruit fly) TR30585_c0_g1_i1 Q4UMH6 Y381_RICFE 8.00E-06 GO:0015969 guanosine tetraphosphate metabolic process IPR002110; IPR020683; IPR007685; Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR30585_c0_g1_i2 O90760 V031_FOWPN 3.00E-06 IPR002110; IPR020683; IPR018272; Putative ankyrin repeat protein FPV031 ANK3 FPV031 Fowlpox virus (strain NVSL) (FPV) TR30588_c8_g3_i1 A2VE29 ITIH5_BOVIN 7.00E-62 GO:0005576; GO:0030212; GO:0004867 extracellular region; hyaluronan metabolic process; serine-type endopeptidase inhibitor activity IPR010600; IPR013694; IPR002035; Inter-alpha-trypsin inhibitor heavy chain H5 (ITI heavy chain H5) (ITI-HC5) (Inter-alpha-inhibitor heavy chain 5) ITIH5 Bos taurus (Bovine) TR30588_c8_g3_i2 P97280 ITIH3_MESAU 6.00E-76 GO:0005576; GO:0030212; GO:0004867 extracellular region; hyaluronan metabolic process; serine-type endopeptidase inhibitor activity IPR010600; IPR013694; IPR002035; Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) ITIH3 Mesocricetus auratus (Golden hamster) TR30590_c0_g1_i2 Q96MP8 KCTD7_HUMAN 1.00E-19 GO:0008219; GO:0005829; GO:0005886; GO:0051260 cell death; cytosol; plasma membrane; protein homooligomerization IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein KCTD7 KCTD7 Homo sapiens (Human) TR30592_c0_g1_i3 Q96MM6 HS12B_HUMAN 7.00E-78 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR30594_c2_g1_i1 A2AIP0 F166B_MOUSE 6.00E-15 IPR018902; Protein FAM166B Fam166b Mus musculus (Mouse) TR30594_c2_g1_i2 A8MTA8 F166B_HUMAN 5.00E-14 IPR018902; Protein FAM166B FAM166B Homo sapiens (Human) TR30595_c1_g1_i1 O42281 PRPH2_CHICK 7.00E-13 GO:0007155; GO:0016021; GO:0060041; GO:0007601 cell adhesion; integral to membrane; retina development in camera-type eye; visual perception IPR000830; IPR018498; IPR018499; IPR008952; Peripherin-2 (CRDS1) (Photoreceptor outer segment membrane glycoprotein 1) (Retinal degeneration slow protein) PRPH2 RDS Gallus gallus (Chicken) TR30601_c0_g1_i2 Q20591 VA0E_CAEEL 5.00E-07 GO:0015991; GO:0043296; GO:0016324; GO:0009792; GO:0010172; GO:0015078; GO:0016787; GO:0016021; GO:0033179; GO:0060142 "ATP hydrolysis coupled proton transport; apical junction complex; apical plasma membrane; embryo development ending in birth or egg hatching; embryonic body morphogenesis; hydrogen ion transmembrane transporter activity; hydrolase activity; integral to membrane; proton-transporting V-type ATPase, V0 domain; regulation of syncytium formation by plasma membrane fusion" IPR008389; IPR017385; V-type proton ATPase subunit e (V-ATPase subunit e) (Vacuolar proton pump subunit e) vha-17 F49C12.13 Caenorhabditis elegans TR30602_c0_g1_i1 P83877 TXN4A_MOUSE 2.00E-90 GO:0008380; GO:0051301; GO:0006397; GO:0007067; GO:0005681 RNA splicing; cell division; mRNA processing; mitosis; spliceosomal complex IPR004123; IPR012336; Thioredoxin-like protein 4A (DIM1 protein homolog) (Spliceosomal U5 snRNP-specific 15 kDa protein) (Thioredoxin-like U5 snRNP protein U5-15kD) Txnl4a Dim1 Txnl4 Mus musculus (Mouse) TR30602_c0_g1_i2 P87215 DIMI_SCHPO 2.00E-75 GO:0046540; GO:0051301; GO:0045292; GO:0007067; GO:0005681 "U4/U6 x U5 tri-snRNP complex; cell division; mRNA cis splicing, via spliceosome; mitosis; spliceosomal complex" IPR004123; IPR012336; Mitosis protein dim1 dim1 SPCC16A11.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR30605_c1_g1_i1 Q99KC8 VMA5A_MOUSE 2.00E-07 IPR013694; IPR002035; von Willebrand factor A domain-containing protein 5A (Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog) Vwa5a Loh11cr2a Mus musculus (Mouse) TR30605_c1_g1_i3 Q75WE7 VWA5A_RAT 9.00E-06 IPR013694; IPR002035; von Willebrand factor A domain-containing protein 5A (Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog) (Mast cell surface antigen 1) (Masa-1) Vwa5a Loh11cr2a Masa1 Rattus norvegicus (Rat) TR30606_c0_g1_i2 O95671 ASML_HUMAN 3.00E-58 GO:0008171; GO:0005737 O-methyltransferase activity; cytoplasm IPR025772; IPR003697; IPR001077; IPR011991; N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-) ASMTL Homo sapiens (Human) TR30608_c0_g1_i1 Q9N1F5 GSTO1_PIG 5.00E-14 GO:0019852; GO:0071243; GO:0005737; GO:0005829; GO:0045174; GO:0004364; GO:0050610; GO:0042178 L-ascorbic acid metabolic process; cellular response to arsenic-containing substance; cytoplasm; cytosol; glutathione dehydrogenase (ascorbate) activity; glutathione transferase activity; methylarsonate reductase activity; xenobiotic catabolic process IPR010987; IPR004045; IPR004046; IPR005442; IPR012336; Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R) GSTO1 Sus scrofa (Pig) TR30608_c0_g1_i2 Q8L7C9 GSTUK_ARATH 1.00E-15 GO:0048046; GO:0009507; GO:0005829; GO:0004364; GO:0005634; GO:0040008; GO:2000030; GO:0009636; GO:0009407 apoplast; chloroplast; cytosol; glutathione transferase activity; nucleus; regulation of growth; regulation of response to red or far red light; response to toxic substance; toxin catabolic process IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase U20 (AtGSTU20) (EC 2.5.1.18) (FIN219-interacting protein 1) (GST class-tau member 20) GSTU20 FIP1 At1g78370 F3F9.11 Arabidopsis thaliana (Mouse-ear cress) TR30610_c2_g1_i1 Q08824 PARP1_ONCMA 5.00E-19 GO:0003677; GO:0003950; GO:0046872; GO:0005634; GO:0006471 DNA binding; NAD+ ADP-ribosyltransferase activity; metal ion binding; nucleus; protein ADP-ribosylation IPR012317; IPR004102; Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Fragment) parp1 adprt Oncorhynchus masou (Cherry salmon) (Masu salmon) TR30610_c2_g1_i2 Q9TXQ1 PME5_CAEEL 2.00E-57 GO:0006281; GO:0003950; GO:0043069; GO:0005634; GO:0006471 DNA repair; NAD+ ADP-ribosyltransferase activity; negative regulation of programmed cell death; nucleus; protein ADP-ribosylation IPR002110; IPR020683; IPR012317; IPR004102; IPR008893; Poly(ADP-ribose) polymerase pme-5 (EC 2.4.2.30) (Poly ADP-ribose metabolism enzyme 5) pme-5 ZK1005.1 Caenorhabditis elegans TR30610_c3_g1_i1 Q8C8R3 ANK2_MOUSE 2.00E-08 GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005887; GO:0014704; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086015; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307 "M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; integral to plasma membrane; intercalated disc; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of SA node cell action potential; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Brain ankyrin) Ank2 Mus musculus (Mouse) TR30611_c1_g1_i1 Q117Z4 UREF_TRIEI 9.00E-19 GO:0005737; GO:0016151; GO:0006807 cytoplasm; nickel cation binding; nitrogen compound metabolic process IPR002639; Urease accessory protein UreF ureF Tery_0751 Trichodesmium erythraeum (strain IMS101) TR30614_c1_g1_i1 Q27274 RO60_CAEEL 7.00E-43 GO:0003723; GO:0005737; GO:0046872; GO:0030529 RNA binding; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein homolog rop-1 C12D8.11 Caenorhabditis elegans TR30614_c1_g1_i2 P42700 RO60_XENLA 1.00E-48 GO:0003723; GO:0030030; GO:0005737; GO:0046872; GO:0030529 RNA binding; cell projection organization; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) trove2 Xenopus laevis (African clawed frog) TR30618_c0_g1_i1 Q96QE5 TEFM_HUMAN 3.00E-13 GO:0030337; GO:0042645; GO:0003676; GO:0006119; GO:0006355; GO:0030529; GO:0006390 "DNA polymerase processivity factor activity; mitochondrial nucleoid; nucleic acid binding; oxidative phosphorylation; regulation of transcription, DNA-dependent; ribonucleoprotein complex; transcription from mitochondrial promoter" IPR012337; IPR010994; IPR023097; "Transcription elongation factor, mitochondrial" TEFM C17orf42 Homo sapiens (Human) TR30620_c0_g1_i1 P55036 PSMD4_HUMAN 2.00E-129 GO:0006977; GO:0000082; GO:0031145; GO:0002479; GO:0006915; GO:0005829; GO:0010467; GO:0016071; GO:0043066; GO:0051436; GO:0005654; GO:0051437; GO:0022624; GO:0008540; GO:0000209; GO:0006521; GO:0044281; GO:0016032 Itself; Q16186; P48510; Q9SII8; P24610; P54725; Q84L32; P54727; Q62921; Q9P0W5; P0CG48; Q9UMX0; Q9UHD9; Q9Y5K5 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G1/S transition of mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic process; cytosol; gene expression; mRNA metabolic process; negative regulation of apoptotic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; proteasome accessory complex; proteasome regulatory particle, base subcomplex; protein polyubiquitination; regulation of cellular amino acid metabolic process; small molecule metabolic process; viral process" IPR027040; IPR003903; IPR002035; 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein) PSMD4 MCB1 Homo sapiens (Human) TR30621_c0_g1_i1 Q6DJF8 MET23_XENLA 1.00E-65 GO:0005737; GO:0016021; GO:0008168 cytoplasm; integral to membrane; methyltransferase activity IPR019410; Methyltransferase-like protein 23 (EC 2.1.1.-) mettl23 Xenopus laevis (African clawed frog) TR30622_c0_g1_i1 Q8N3Y1 FBXW8_HUMAN 2.00E-38 GO:0031467; GO:0005794; GO:0007030; GO:0019005; GO:0060716; GO:0048471; GO:0050775; GO:0060712 P01106 Cul7-RING ubiquitin ligase complex; Golgi apparatus; Golgi organization; SCF ubiquitin ligase complex; labyrinthine layer blood vessel development; perinuclear region of cytoplasm; positive regulation of dendrite morphogenesis; spongiotrophoblast layer development IPR001810; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29) FBXW8 FBW6 FBW8 FBX29 FBXO29 FBXW6 Homo sapiens (Human) TR30622_c0_g1_i2 Q8BIA4 FBXW8_MOUSE 8.00E-35 GO:0031467; GO:0005794; GO:0007030; GO:0019005; GO:0060716; GO:0048471; GO:0050775; GO:0060712; GO:0006511 Cul7-RING ubiquitin ligase complex; Golgi apparatus; Golgi organization; SCF ubiquitin ligase complex; labyrinthine layer blood vessel development; perinuclear region of cytoplasm; positive regulation of dendrite morphogenesis; spongiotrophoblast layer development; ubiquitin-dependent protein catabolic process IPR001810; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) Fbxw8 Mus musculus (Mouse) TR30624_c0_g1_i1 Q9GPQ9 RACJ_DICDI 2.00E-06 GO:0005525; GO:0005622; GO:0005886; GO:0019953; GO:0007264 GTP binding; intracellular; plasma membrane; sexual reproduction; small GTPase mediated signal transduction IPR027417; IPR001806; IPR003578; Rho-related protein racJ racJ DDB_G0292560 Dictyostelium discoideum (Slime mold) TR30624_c0_g1_i2 Q9SSX0 RAC1_ORYSJ 2.00E-37 GO:0005525; GO:0006915; GO:0005737; GO:0006952; GO:0016020; GO:0007264 GTP binding; apoptotic process; cytoplasm; defense response; membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Rac-like GTP-binding protein 1 (OsRac1) RAC1 Os01g0229400 LOC_Os01g12900 Oryza sativa subsp. japonica (Rice) TR30624_c0_g1_i3 Q24192 RHOL_DROME 2.00E-35 GO:0005525; GO:0003924; GO:0007298; GO:0005509; GO:0007155; GO:0007516; GO:0035099; GO:0005622; GO:0035011; GO:0007498; GO:0005886; GO:0022409; GO:0008360; GO:0006974; GO:0007264 GTP binding; GTPase activity; border follicle cell migration; calcium ion binding; cell adhesion; hemocyte development; hemocyte migration; intracellular; melanotic encapsulation of foreign target; mesoderm development; plasma membrane; positive regulation of cell-cell adhesion; regulation of cell shape; response to DNA damage stimulus; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Ras-like GTP-binding protein RhoL RhoL Drac3 CG9366 Drosophila melanogaster (Fruit fly) TR30624_c0_g1_i4 Q9JJL4 RHOQ_RAT 2.00E-43 GO:0005525; GO:0003924; GO:0005884; GO:0005737; GO:0008286; GO:0045121; GO:0005886; GO:0051491; GO:0046326; GO:0045944; GO:0007264 GTP binding; GTPase activity; actin filament; cytoplasm; insulin receptor signaling pathway; membrane raft; plasma membrane; positive regulation of filopodium assembly; positive regulation of glucose import; positive regulation of transcription from RNA polymerase II promoter; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) Rhoq Tc10 Rattus norvegicus (Rat) TR30625_c0_g1_i1 Q6P575 YV019_HUMAN 2.00E-17 GO:0005975; GO:0004553 "carbohydrate metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds" IPR008979; IPR006104; Putative uncharacterized protein LOC91316 Homo sapiens (Human) TR30625_c1_g1_i1 P05804 BGLR_ECOLI 2.00E-122 GO:0004566; GO:0019391 P18843 beta-glucuronidase activity; glucuronoside catabolic process IPR008979; IPR006101; IPR013812; IPR023232; IPR023230; IPR006102; IPR006104; IPR006103; IPR013781; IPR017853; Beta-glucuronidase (GUS) (EC 3.2.1.31) (Beta-D-glucuronoside glucuronosohydrolase) uidA gurA gusA b1617 JW1609 Escherichia coli (strain K12) TR30625_c1_g1_i2 Q4FAT7 BGLR_PIG 0 GO:0004566; GO:0005975; GO:0005764 beta-glucuronidase activity; carbohydrate metabolic process; lysosome IPR008979; IPR006101; IPR013812; IPR023232; IPR023230; IPR006102; IPR006104; IPR006103; IPR013781; IPR017853; Beta-glucuronidase (EC 3.2.1.31) GUSB Sus scrofa (Pig) TR30628_c0_g2_i1 Q9Y2U8 MAN1_HUMAN 9.00E-65 GO:0003677; GO:0005639; GO:0030514; GO:0032926; GO:0030512; GO:0000166; GO:0051726; GO:0035914 DNA binding; integral to nuclear inner membrane; negative regulation of BMP signaling pathway; negative regulation of activin receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; nucleotide binding; regulation of cell cycle; skeletal muscle cell differentiation IPR018996; IPR011015; IPR003887; IPR012677; Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) LEMD3 MAN1 Homo sapiens (Human) TR30629_c1_g3_i1 Q7PRB5 OPI10_ANOGA 3.00E-35 IPR008493; Protein OPI10 homolog AGAP002426 Anopheles gambiae (African malaria mosquito) TR30629_c1_g4_i1 Q6DCU7 HIKES_XENLA 1.00E-43 GO:0030544; GO:0034605; GO:0005829; GO:0005634; GO:0006606; GO:0008565 Hsp70 protein binding; cellular response to heat; cytosol; nucleus; protein import into nucleus; protein transporter activity IPR008493; Protein Hikeshi Xenopus laevis (African clawed frog) TR30631_c1_g1_i1 B6ZK76 IRL1A_DANRE 4.00E-10 GO:0005737; GO:0016021; GO:0004908; GO:0005886 cytoplasm; integral to membrane; interleukin-1 receptor activity; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR015621; IPR004074; IPR000157; Interleukin-1 receptor accessory protein-like 1-A il1rapl1a zgc:152866 Danio rerio (Zebrafish) (Brachydanio rerio) TR30631_c1_g2_i2 P59822 IL1AP_MACMU 2.00E-17 GO:0005576; GO:0016021; GO:0004908; GO:0005886 extracellular region; integral to membrane; interleukin-1 receptor activity; plasma membrane IPR007110; IPR013783; IPR003599; IPR015621; IPR004074; IPR000157; Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) IL1RAP Macaca mulatta (Rhesus macaque) TR30631_c2_g3_i1 Q9UL59 ZN214_HUMAN 1.00E-38 GO:0003677; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 214 (BWSCR2-associated zinc finger protein 1) (BAZ-1) ZNF214 BAZ1 Homo sapiens (Human) TR30634_c1_g1_i1 B6PLN3 RCL_BRAFL 1.00E-09 GO:0005737; GO:0070694; GO:0009159; GO:0050144; GO:0009117; GO:0005634; GO:0030307 cytoplasm; deoxyribonucleoside 5'-monophosphate N-glycosidase activity; deoxyribonucleoside monophosphate catabolic process; nucleoside deoxyribosyltransferase activity; nucleotide metabolic process; nucleus; positive regulation of cell growth IPR007710; Putative 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (EC 3.2.2.-) BRAFLDRAFT_288561 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR30634_c4_g1_i1 A7RLE5 RCL_NEMVE 1.00E-25 GO:0005737; GO:0070694; GO:0009159; GO:0050144; GO:0009117; GO:0005634; GO:0030307 cytoplasm; deoxyribonucleoside 5'-monophosphate N-glycosidase activity; deoxyribonucleoside monophosphate catabolic process; nucleoside deoxyribosyltransferase activity; nucleotide metabolic process; nucleus; positive regulation of cell growth IPR007710; Putative 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (EC 3.2.2.-) v1g160099 Nematostella vectensis (Starlet sea anemone) TR30635_c2_g2_i2 Q9NZ63 CI078_HUMAN 1.00E-71 GO:0005737; GO:0005634 cytoplasm; nucleus IPR010756; Uncharacterized protein C9orf78 (Hepatocellular carcinoma-associated antigen 59) C9orf78 HCA59 Homo sapiens (Human) TR30637_c1_g1_i1 Q9UIW2 PLXA1_HUMAN 7.00E-08 GO:0007411; GO:0005737; GO:0060666; GO:0016021; GO:0005634; GO:0005886; GO:0017154; GO:0002116 axon guidance; cytoplasm; dichotomous subdivision of terminal units involved in salivary gland branching; integral to membrane; nucleus; plasma membrane; semaphorin receptor activity; semaphorin receptor complex IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A1 (Semaphorin receptor NOV) PLXNA1 NOV PLXN1 Homo sapiens (Human) TR30637_c8_g1_i1 Q5VTM2 AGAP9_HUMAN 2.00E-24 GO:0008060; GO:0005543; GO:0043547; GO:0032312; GO:0008270 ARF GTPase activator activity; phospholipid binding; positive regulation of GTPase activity; regulation of ARF GTPase activity; zinc ion binding IPR020683; IPR001164; IPR027417; IPR011993; IPR001849; "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9 (AGAP-9) (Centaurin-gamma-like family member 6)" AGAP9 CTGLF6 Homo sapiens (Human) TR30637_c8_g1_i2 Q14692 BMS1_HUMAN 1.00E-145 GO:0005524; GO:0005730; GO:0042255 ATP binding; nucleolus; ribosome assembly IPR012948; IPR007034; IPR027417; Ribosome biogenesis protein BMS1 homolog (Ribosome assembly protein BMS1 homolog) BMS1 BMS1L KIAA0187 Homo sapiens (Human) TR30638_c3_g1_i1 Q9Y2I7 FYV1_HUMAN 4.00E-30 GO:0000285; GO:0016308; GO:0005524; GO:0000139; GO:0044267; GO:0031410; GO:0005829; GO:0031901; GO:0035556; GO:0031902; GO:0045121; GO:0046872; GO:0032288; GO:0048471; GO:0043813; GO:0034504; GO:0042147; GO:0044281 "1-phosphatidylinositol-3-phosphate 5-kinase activity; 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding; Golgi membrane; cellular protein metabolic process; cytoplasmic vesicle; cytosol; early endosome membrane; intracellular signal transduction; late endosome membrane; membrane raft; metal ion binding; myelin assembly; perinuclear region of cytoplasm; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; protein localization to nucleus; retrograde transport, endosome to Golgi; small molecule metabolic process" IPR002423; IPR000591; IPR027409; IPR027483; IPR002498; IPR027484; IPR016034; IPR027410; IPR011991; IPR000306; IPR017455; IPR011011; IPR013083; 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) PIKFYVE KIAA0981 PIP5K3 Homo sapiens (Human) TR30638_c9_g2_i1 Q9Z1T6 FYV1_MOUSE 3.00E-79 GO:0000285; GO:0016308; GO:0052810; GO:0005524; GO:0000139; GO:0044267; GO:0031410; GO:0030659; GO:0005829; GO:0031901; GO:0035556; GO:0031902; GO:0032288; GO:0048471; GO:0012506; GO:0008270 1-phosphatidylinositol-3-phosphate 5-kinase activity; 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-kinase activity; ATP binding; Golgi membrane; cellular protein metabolic process; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; early endosome membrane; intracellular signal transduction; late endosome membrane; myelin assembly; perinuclear region of cytoplasm; vesicle membrane; zinc ion binding IPR002423; IPR000591; IPR027409; IPR027483; IPR002498; IPR027484; IPR016034; IPR027410; IPR011991; IPR000306; IPR017455; IPR011011; IPR013083; 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (p235) Pikfyve Kiaa0981 Pip5k3 Mus musculus (Mouse) TR30638_c9_g2_i2 B0G126 FYV1_DICDI 6.00E-57 GO:0000285; GO:0005524; GO:0044267; GO:0046872; GO:0005739 1-phosphatidylinositol-3-phosphate 5-kinase activity; ATP binding; cellular protein metabolic process; metal ion binding; mitochondrion IPR002423; IPR027409; IPR027483; IPR002498; IPR027484; IPR000306; IPR017455; IPR011011; IPR013083; 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) pip5k3 DDB_G0279149 Dictyostelium discoideum (Slime mold) TR30640_c0_g2_i1 Q2TBT5 RNH2A_BOVIN 2.00E-106 GO:0003723; GO:0006401; GO:0046872; GO:0005634; GO:0004523; GO:0032299 RNA binding; RNA catabolic process; metal ion binding; nucleus; ribonuclease H activity; ribonuclease H2 complex IPR004649; IPR001352; IPR024567; IPR023160; IPR012337; Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A) RNASEH2A Bos taurus (Bovine) TR30644_c0_g2_i1 Q9CZJ2 HS12B_MOUSE 8.00E-107 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR30644_c0_g2_i2 Q54BE0 HS7C3_DICDI 4.00E-09 GO:0005524 ATP binding IPR018181; IPR013126; Heat shock cognate 70 kDa protein 3 (HSC70-3) DDB_G0293674 Dictyostelium discoideum (Slime mold) TR30644_c0_g2_i4 Q96MM6 HS12B_HUMAN 3.00E-89 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR30645_c4_g2_i1 A6NJL1 ZSA5B_HUMAN 7.00E-12 GO:0003677; GO:0046872; GO:0005634; GO:0000981 DNA binding; metal ion binding; nucleus; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 5B ZSCAN5B Homo sapiens (Human) TR30645_c4_g3_i1 Q0V8G8 ZBTB6_BOVIN 9.00E-07 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 6 (Zinc finger protein 482) ZBTB6 ZNF482 Bos taurus (Bovine) TR30646_c2_g2_i4 Q4ZJM9 C1QL4_MOUSE 9.00E-06 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) TR30647_c2_g2_i1 P61129 ZC3H6_HUMAN 2.00E-15 GO:0046872 metal ion binding IPR000571; Zinc finger CCCH domain-containing protein 6 ZC3H6 KIAA2035 ZC3HDC6 Homo sapiens (Human) TR30647_c4_g2_i1 O74463 YQC1_SCHPO 6.00E-06 GO:0005829; GO:0046872 cytosol; metal ion binding IPR026290; IPR000571; Uncharacterized protein C1739.01 SPCC1739.01 SPCC1906.05 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR30648_c0_g1_i1 P00378 DYR_CHICK 3.00E-37 GO:0050661; GO:0004146; GO:0008144; GO:0006545; GO:0003729; GO:0009165; GO:0006730; GO:0031427; GO:0046654; GO:0046653 NADP binding; dihydrofolate reductase activity; drug binding; glycine biosynthetic process; mRNA binding; nucleotide biosynthetic process; one-carbon metabolic process; response to methotrexate; tetrahydrofolate biosynthetic process; tetrahydrofolate metabolic process IPR012259; IPR024072; IPR017925; IPR001796; "Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1." Dihydrofolate reductase (EC 1.5.1.3) DHFR Gallus gallus (Chicken) TR30648_c0_g2_i1 Q54277 DYR_STAHA 3.00E-11 GO:0050661; GO:0004146; GO:0006545; GO:0009165; GO:0006730; GO:0046677; GO:0031427; GO:0046654 NADP binding; dihydrofolate reductase activity; glycine biosynthetic process; nucleotide biosynthetic process; one-carbon metabolic process; response to antibiotic; response to methotrexate; tetrahydrofolate biosynthetic process IPR012259; IPR024072; IPR017925; IPR001796; "Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1." Dihydrofolate reductase (EC 1.5.1.3) dfrD Staphylococcus haemolyticus TR30650_c0_g1_i1 I0IUP3 MCM8_CHICK 0 GO:0005524; GO:0003677; GO:0006260; GO:0097362; GO:0000724; GO:0004386; GO:0005634 ATP binding; DNA binding; DNA replication; MCM8-MCM9 complex; double-strand break repair via homologous recombination; helicase activity; nucleus IPR003593; IPR001208; IPR012340; IPR027417; IPR004039; DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8) MCM8 RCJMB04_5o15 Gallus gallus (Chicken) TR30650_c1_g2_i1 Q9UJA3 MCM8_HUMAN 0 GO:0005524; GO:0003677; GO:0006271; GO:0000082; GO:0097362; GO:0000724; GO:0007292; GO:0004386; GO:0048232; GO:0005654; GO:0006974 ATP binding; DNA binding; DNA strand elongation involved in DNA replication; G1/S transition of mitotic cell cycle; MCM8-MCM9 complex; double-strand break repair via homologous recombination; female gamete generation; helicase activity; male gamete generation; nucleoplasm; response to DNA damage stimulus IPR003593; IPR001208; IPR027925; IPR012340; IPR027417; DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8) MCM8 C20orf154 Homo sapiens (Human) TR30651_c1_g1_i1 Q96MP8 KCTD7_HUMAN 2.00E-13 GO:0008219; GO:0005829; GO:0005886; GO:0051260 cell death; cytosol; plasma membrane; protein homooligomerization IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein KCTD7 KCTD7 Homo sapiens (Human) TR30652_c0_g1_i2 Q9Y2R4 DDX52_HUMAN 2.00E-131 GO:0005524; GO:0008026; GO:0003723; GO:0005730 ATP binding; ATP-dependent helicase activity; RNA binding; nucleolus IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; Probable ATP-dependent RNA helicase DDX52 (EC 3.6.4.13) (ATP-dependent RNA helicase ROK1-like) (DEAD box protein 52) DDX52 ROK1 HUSSY-19 Homo sapiens (Human) TR30652_c0_g2_i1 A5DZT7 DBP10_LODEL 3.00E-26 GO:0005524; GO:0008026; GO:0003723; GO:0005730; GO:0006364 ATP binding; ATP-dependent helicase activity; RNA binding; nucleolus; rRNA processing IPR012541; IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DBP10 (EC 3.6.4.13) DBP10 LELG_02874 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus) TR30655_c0_g1_i1 O73817 PSB3_ONCMY 2.00E-127 GO:0005737; GO:0005634; GO:0005839; GO:0051603; GO:0004298 cytoplasm; nucleus; proteasome core complex; proteolysis involved in cellular protein catabolic process; threonine-type endopeptidase activity IPR016050; IPR001353; IPR023333; Proteasome subunit beta type-3 (EC 3.4.25.1) (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain) psmb3 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR30656_c2_g1_i1 Q8TCU4 ALMS1_HUMAN 4.00E-18 GO:0000086; GO:0005813; GO:0005929; GO:0005829; GO:0016197; GO:0005932; GO:0051492; GO:0000922 O75923 G2/M transition of mitotic cell cycle; centrosome; cilium; cytosol; endosomal transport; microtubule basal body; regulation of stress fiber assembly; spindle pole Alstrom syndrome protein 1 ALMS1 KIAA0328 Homo sapiens (Human) TR30657_c0_g1_i1 C3Z724 UBE2S_BRAFL 4.00E-87 GO:0005524; GO:0051488; GO:0005680; GO:0031145; GO:0051301; GO:0010458; GO:0010994; GO:0070979; GO:0004842 ATP binding; activation of anaphase-promoting complex activity; anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; exit from mitosis; free ubiquitin chain polymerization; protein K11-linked ubiquitination; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 S (EC 6.3.2.19) (Ubiquitin carrier protein S) (Ubiquitin-protein ligase S) BRAFLDRAFT_259979 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR30658_c0_g1_i1 Q5F339 CCHL_CHICK 2.00E-95 GO:0004408; GO:0046872; GO:0005743 holocytochrome-c synthase activity; metal ion binding; mitochondrial inner membrane IPR000511; Cytochrome c-type heme lyase (CCHL) (EC 4.4.1.17) (Holocytochrome c-type synthase) HCCS RCJMB04_37l21 Gallus gallus (Chicken) TR30662_c0_g1_i1 Q7A5L8 TDCB_STAAN 4.00E-48 GO:0004794; GO:0070689; GO:0000166; GO:0030170 L-threonine ammonia-lyase activity; L-threonine catabolic process to propionate; nucleotide binding; pyridoxal phosphate binding IPR000634; IPR005789; IPR001926; Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine: step 1/4. L-threonine dehydratase catabolic TdcB (EC 4.3.1.19) (Threonine deaminase) tdcB SA1271 Staphylococcus aureus (strain N315) TR30663_c1_g1_i1 Q92847 GHSR_HUMAN 1.00E-08 GO:0008154; GO:0008343; GO:0009986; GO:0032869; GO:0046697; GO:0001616; GO:0030252; GO:0016520; GO:0009755; GO:0016021; GO:0045121; GO:0050728; GO:0046676; GO:0032691; GO:0045409; GO:0042536; GO:0043005; GO:0017046; GO:0005886; GO:0032100; GO:0045923; GO:0043568; GO:0040018; GO:0043134; GO:0051963; GO:0032094 actin polymerization or depolymerization; adult feeding behavior; cell surface; cellular response to insulin stimulus; decidualization; growth hormone secretagogue receptor activity; growth hormone secretion; growth hormone-releasing hormone receptor activity; hormone-mediated signaling pathway; integral to membrane; membrane raft; negative regulation of inflammatory response; negative regulation of insulin secretion; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 biosynthetic process; negative regulation of tumor necrosis factor biosynthetic process; neuron projection; peptide hormone binding; plasma membrane; positive regulation of appetite; positive regulation of fatty acid metabolic process; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; regulation of hindgut contraction; regulation of synapse assembly; response to food IPR003905; IPR000276; IPR017452; Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) GHSR Homo sapiens (Human) TR30665_c2_g1_i1 Q57664 GALE_METJA 2.00E-17 GO:0003978; GO:0044237; GO:0050662; GO:0006012 UDP-glucose 4-epimerase activity; cellular metabolic process; coenzyme binding; galactose metabolic process IPR001509; IPR016040; Carbohydrate metabolism; galactose metabolism. Putative UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-galactose 4-epimerase) MJ0211 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR30668_c0_g2_i1 P0C660 PHYD1_CAEBR 3.00E-06 GO:0051213; GO:0046872 dioxygenase activity; metal ion binding IPR008775; Phytanoyl-CoA dioxygenase domain-containing protein 1 homolog (EC 1.-.-.-) CBG00325 Caenorhabditis briggsae TR30669_c0_g2_i1 F1QGZ6 MELK_DANRE 5.00E-27 GO:0005524; GO:0006915; GO:0005509; GO:0005938; GO:0007049; GO:0048821; GO:0008289; GO:0061351; GO:0004715; GO:0005886; GO:0043065; GO:0046777; GO:0004674; GO:0008016 ATP binding; apoptotic process; calcium ion binding; cell cortex; cell cycle; erythrocyte development; lipid binding; neural precursor cell proliferation; non-membrane spanning protein tyrosine kinase activity; plasma membrane; positive regulation of apoptotic process; protein autophosphorylation; protein serine/threonine kinase activity; regulation of heart contraction IPR028375; IPR001772; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Maternal embryonic leucine zipper kinase (zMelk) (EC 2.7.11.1) (Protein kinase PK38) melk Danio rerio (Zebrafish) (Brachydanio rerio) TR30671_c0_g1_i1 Q9Y248 PSF2_HUMAN 2.00E-80 GO:0006271; GO:0000278; GO:0005654 O96017 DNA strand elongation involved in DNA replication; mitotic cell cycle; nucleoplasm IPR021151; IPR007257; IPR016906; DNA replication complex GINS protein PSF2 (GINS complex subunit 2) GINS2 PSF2 CGI-122 DC5 HSPC037 Homo sapiens (Human) TR30672_c1_g2_i1 Q9VFP2 RDX_DROME 0 GO:0042067; GO:0046331; GO:0042308; GO:0045879; GO:0005634; GO:0046330; GO:0043065; GO:0031648; GO:0042803; GO:0016567; GO:0030162; GO:0007367 establishment of ommatidial planar polarity; lateral inhibition; negative regulation of protein import into nucleus; negative regulation of smoothened signaling pathway; nucleus; positive regulation of JNK cascade; positive regulation of apoptotic process; protein destabilization; protein homodimerization activity; protein ubiquitination; regulation of proteolysis; segment polarity determination IPR000210; IPR011333; IPR013069; IPR002083; IPR008974; Protein modification; protein ubiquitination. Protein roadkill (Hh-induced MATH and BTB domain-containing protein) rdx HIB CG12537 Drosophila melanogaster (Fruit fly) TR30674_c1_g1_i1 O35347 DGCR6_MOUSE 2.00E-47 IPR010849; Protein DGCR6 (DiGeorge syndrome critical region 6 homolog) Dgcr6 Mus musculus (Mouse) TR30675_c0_g1_i1 Q24K15 ANGP4_BOVIN 2.00E-54 GO:0001525; GO:0005576 angiogenesis; extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) TR30676_c0_g1_i1 Q9V4M2 WECH_DROME 1.00E-07 GO:0030154; GO:0002168; GO:0005622; GO:0016203; GO:0005927; GO:0033632; GO:0008270 cell differentiation; instar larval development; intracellular; muscle attachment; muscle tendon junction; regulation of cell-cell adhesion mediated by integrin; zinc ion binding IPR011042; IPR001258; IPR013017; IPR000315; Protein wech (Protein dappled) wech dpld CG42396 Drosophila melanogaster (Fruit fly) TR30678_c0_g1_i1 P58545 BTBD3_MOUSE 2.00E-121 IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 3 Btbd3 Mus musculus (Mouse) TR30678_c0_g2_i1 Q17551 RPM1_CAEEL 2.00E-11 GO:0030424; GO:0010171; GO:0040011; GO:0043409; GO:0031594; GO:0005634; GO:0018991; GO:0036062; GO:0031647; GO:0050807; GO:0006355; GO:0006351; GO:0004842; GO:0008270 "axon; body morphogenesis; locomotion; negative regulation of MAPK cascade; neuromuscular junction; nucleus; oviposition; presynaptic periactive zone; regulation of protein stability; regulation of synapse organization; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR004939; IPR008979; IPR027047; IPR012983; IPR009091; IPR000408; IPR000315; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase rpm-1 (EC 6.3.2.-) (Pam/highwire/rpm-1 protein) (Regulator of presynaptic morphology protein 1) (Synapse defective protein 3) rpm-1 syd-3 C01B7.6 Caenorhabditis elegans TR30679_c0_g1_i1 Q3U2J5 CMKMT_MOUSE 3.00E-76 GO:0005794; GO:0018025; GO:0005634 Golgi apparatus; calmodulin-lysine N-methyltransferase activity; nucleus IPR025800; IPR019410; Calmodulin-lysine N-methyltransferase (CLNMT) (CaM KMT) (EC 2.1.1.60) Camkmt Clnmt Mus musculus (Mouse) TR30680_c0_g1_i1 O14299 WIS4_SCHPO 2.00E-15 GO:0005524; GO:0004709; GO:0051519; GO:0005829; GO:0007346; GO:0051403 ATP binding; MAP kinase kinase kinase activity; activation of bipolar cell growth; cytosol; regulation of mitotic cell cycle; stress-activated MAPK cascade IPR011009; IPR017240; IPR000719; IPR002290; IPR008271; MAP kinase kinase kinase wis4 (EC 2.7.11.25) (MAP kinase kinase kinase wak1) (MAP kinase kinase kinase wik1) wis4 wak1 wik1 SPAC9G1.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR30680_c0_g1_i2 Q9Y0Y6 NRBP_DROME 7.00E-122 GO:0005524; GO:0006888; GO:0005794; GO:0005938; GO:0005829; GO:0012505; GO:0042803; GO:0009306; GO:0042127; GO:0008361; GO:0016772 "ATP binding; ER to Golgi vesicle-mediated transport; Golgi apparatus; cell cortex; cytosol; endomembrane system; protein homodimerization activity; protein secretion; regulation of cell proliferation; regulation of cell size; transferase activity, transferring phosphorus-containing groups" IPR011009; IPR000719; Nuclear receptor-binding protein homolog (MLF1-adaptor molecule) Madm CG1098 Drosophila melanogaster (Fruit fly) TR30680_c0_g1_i3 Q55CW1 SAMKD_DICDI 2.00E-08 GO:0005524; GO:0004672 ATP binding; protein kinase activity IPR011009; IPR000719; IPR001660; IPR013761; Probable inactive serine/threonine-protein kinase samkD (SAM domain-containing protein kinase D) samkD SAMK-D smkD DDB_G0270680 Dictyostelium discoideum (Slime mold) TR30680_c0_g1_i4 Q5RBH9 NRBP_PONAB 2.00E-133 GO:0006888; GO:0005938; GO:0012505; GO:0030027; GO:0016020; GO:0048471; GO:0006468; GO:0016772 "ER to Golgi vesicle-mediated transport; cell cortex; endomembrane system; lamellipodium; membrane; perinuclear region of cytoplasm; protein phosphorylation; transferase activity, transferring phosphorus-containing groups" IPR011009; IPR000719; Nuclear receptor-binding protein NRBP1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR30680_c0_g1_i5 Q2MHE4 HT1_ARATH 5.00E-12 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR001245; IPR008271; Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High leaf temperature protein 1) HT1 At1g62400 F24O1.13 Arabidopsis thaliana (Mouse-ear cress) TR30680_c0_g2_i2 Q91V36 NRBP2_MOUSE 7.00E-43 GO:0005524; GO:0005737; GO:0016242; GO:0043524; GO:0030182; GO:0004672 ATP binding; cytoplasm; negative regulation of macroautophagy; negative regulation of neuron apoptotic process; neuron differentiation; protein kinase activity IPR011009; IPR000719; Nuclear receptor-binding protein 2 Nrbp2 Mus musculus (Mouse) TR30686_c0_g1_i2 E2IYB3 FCNV1_VARKO 1.00E-31 GO:0005576 extracellular region IPR008160; IPR014716; IPR002181; Veficolin-1 (Fragment) Varanus komodoensis (Komodo dragon) TR30686_c0_g1_i3 D8VNT0 FCNV4_CERRY 3.00E-63 GO:0005576 extracellular region IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ryncolin-4 Cerberus rynchops (Dog-faced water snake) TR30691_c1_g1_i2 Q9BX68 HINT2_HUMAN 2.00E-49 GO:0006915; GO:0016787; GO:0005739; GO:0000166; GO:0006694 apoptotic process; hydrolase activity; mitochondrion; nucleotide binding; steroid biosynthetic process IPR019808; IPR001310; IPR011146; "Histidine triad nucleotide-binding protein 2, mitochondrial (HINT-2) (EC 3.-.-.-) (HINT-3) (HIT-17kDa) (PKCI-1-related HIT protein)" HINT2 Homo sapiens (Human) TR30691_c1_g1_i3 P62958 HINT1_BOVIN 8.00E-60 GO:0005737; GO:0000118; GO:0016787; GO:0072332; GO:0000166; GO:0005886; GO:0009154; GO:0006355; GO:0006351 "cytoplasm; histone deacetylase complex; hydrolase activity; intrinsic apoptotic signaling pathway by p53 class mediator; nucleotide binding; plasma membrane; purine ribonucleotide catabolic process; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019808; IPR001310; IPR011146; Histidine triad nucleotide-binding protein 1 (EC 3.-.-.-) (17 kDa inhibitor of protein kinase C) (Adenosine 5'-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1) HINT1 HINT PKCI1 Bos taurus (Bovine) TR30693_c0_g1_i1 P83941 ELOC_RAT 2.00E-68 GO:0030891; GO:0005634; GO:0032968; GO:0006351; GO:0006511 "VCB complex; nucleus; positive regulation of transcription elongation from RNA polymerase II promoter; transcription, DNA-dependent; ubiquitin-dependent protein catabolic process" IPR011333; IPR001232; IPR016073; Transcription elongation factor B polypeptide 1 (Elongin 15 kDa subunit) (Elongin-C) (EloC) (RNA polymerase II transcription factor SIII subunit C) (SIII p15) (Stromal membrane-associated protein SMAP1B homolog) Tceb1 Rattus norvegicus (Rat) TR30694_c0_g1_i1 Q9PU13 SPD1A_XENLA 6.00E-08 GO:0000187; GO:0006378; GO:0008315; GO:0007275; GO:0005634; GO:0001556; GO:0045737; GO:0051446 activation of MAPK activity; mRNA polyadenylation; meiotic G2/MI transition; multicellular organismal development; nucleus; oocyte maturation; positive regulation of cyclin-dependent protein kinase activity; positive regulation of meiotic cell cycle IPR020984; Speedy protein 1-A (Spy1-A) (Protein Ls26) (Rapid inducer of G2/M progression in oocytes A) (RINGO-A) (XSpy1-A) (p33 ringo-A) (xRINGO-A) spdya-a ls26 spdy1 Xenopus laevis (African clawed frog) TR30694_c4_g1_i1 Q9YGL1 SPD1B_XENLA 3.00E-08 GO:0000187; GO:0030332; GO:0006378; GO:0008315; GO:0007275; GO:0005634; GO:0001556; GO:0045737; GO:0051446 activation of MAPK activity; cyclin binding; mRNA polyadenylation; meiotic G2/MI transition; multicellular organismal development; nucleus; oocyte maturation; positive regulation of cyclin-dependent protein kinase activity; positive regulation of meiotic cell cycle IPR020984; Speedy protein 1-B (Spy1-B) (Protein Ls27) (Rapid inducer of G2/M progression in oocytes B) (RINGO-B) (XSpy1-B) (p33 ringo-B) (xRINGO-B) spdya-b ls27 spdy1 spy1 Xenopus laevis (African clawed frog) TR30694_c4_g2_i1 Q5MJ70 SPDYA_HUMAN 2.00E-07 GO:0000082; GO:0007140; GO:0007275; GO:0005634; GO:0008284; GO:0045737; GO:0006974 G1/S transition of mitotic cell cycle; male meiosis; multicellular organismal development; nucleus; positive regulation of cell proliferation; positive regulation of cyclin-dependent protein kinase activity; response to DNA damage stimulus IPR020984; Speedy protein A (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A) (Speedy-1) (Spy1) SPDYA SPDY1 SPY1 Homo sapiens (Human) TR30694_c5_g1_i1 Q8R496 SPDYA_RAT 3.00E-32 GO:0000082; GO:0007140; GO:0007275; GO:0005634; GO:0008284; GO:0045737; GO:0019901; GO:0006974 G1/S transition of mitotic cell cycle; male meiosis; multicellular organismal development; nucleus; positive regulation of cell proliferation; positive regulation of cyclin-dependent protein kinase activity; protein kinase binding; response to DNA damage stimulus IPR020984; Speedy protein A (GS4) (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (Speedy-1) (Spy1) Spdya Spdy1 Rattus norvegicus (Rat) TR30695_c3_g1_i1 O15394 NCAM2_HUMAN 2.00E-09 GO:0030424; GO:0016021; GO:0007158; GO:0005886 axon; integral to membrane; neuron cell-cell adhesion; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR009138; Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2) NCAM2 NCAM21 Homo sapiens (Human) TR30695_c3_g2_i1 Q149C3 LIGO4_MOUSE 6.00E-08 GO:0016021 integral to membrane IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeat and immunoglobulin-like domain containing-NOGO receptor-interacting protein 4 (Leucine-rich repeat neuronal protein 6D) Lingo4 Lrrn6d Mus musculus (Mouse) TR30695_c4_g1_i1 Q9ET54 PALLD_MOUSE 6.00E-11 GO:0030018; GO:0005884; GO:0005925; GO:0030027; GO:0005634; GO:0001726 Z disc; actin filament; focal adhesion; lamellipodium; nucleus; ruffle IPR007110; IPR013783; IPR013098; IPR003598; Palladin Palld Kiaa0992 Mus musculus (Mouse) TR30695_c4_g1_i2 Q8WX93 PALLD_HUMAN 6.00E-12 GO:0030018; GO:0005884; GO:0007010; GO:0005925; GO:0030027; GO:0051371; GO:0005634; GO:0001726 O94875 Z disc; actin filament; cytoskeleton organization; focal adhesion; lamellipodium; muscle alpha-actinin binding; nucleus; ruffle IPR007110; IPR013783; IPR013098; IPR003598; Palladin (SIH002) (Sarcoma antigen NY-SAR-77) PALLD KIAA0992 CGI-151 Homo sapiens (Human) TR30695_c5_g1_i1 Q15746 MYLK_HUMAN 1.00E-42 GO:0005524; GO:0060414; GO:0032060; GO:0071476; GO:0032154; GO:0005829; GO:0030027; GO:0046872; GO:0004687; GO:0005886; GO:0051928; GO:0030335; GO:0090303; GO:0001725; GO:0014820 P16333 ATP binding; aorta smooth muscle tissue morphogenesis; bleb assembly; cellular hypotonic response; cleavage furrow; cytosol; lamellipodium; metal ion binding; myosin light chain kinase activity; plasma membrane; positive regulation of calcium ion transport; positive regulation of cell migration; positive regulation of wound healing; stress fiber; tonic smooth muscle contraction IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR020675; IPR000719; IPR017441; IPR002290; IPR008271; "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]" MYLK MLCK MLCK1 MYLK1 Homo sapiens (Human) TR30695_c9_g1_i1 P16419 MYPC2_CHICK 8.00E-14 GO:0007155; GO:0032982 cell adhesion; myosin filament IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; "Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform)" MYBPC2 Gallus gallus (Chicken) TR30696_c1_g1_i1 P23025 XPA_HUMAN 5.00E-45 GO:0003684; GO:0008630; GO:0046872; GO:0035264; GO:0005654; GO:0000166; GO:0000718; GO:0009411; GO:0006979; GO:0009636 P15927; Q96EB6; Q9HCS7 "damaged DNA binding; intrinsic apoptotic signaling pathway in response to DNA damage; metal ion binding; multicellular organism growth; nucleoplasm; nucleotide binding; nucleotide-excision repair, DNA damage removal; response to UV; response to oxidative stress; response to toxic substance" IPR009061; IPR000465; IPR022656; IPR022658; IPR022652; DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein) XPA XPAC Homo sapiens (Human) TR30697_c0_g1_i1 Q94521 DNAT_DROME 4.00E-09 GO:0004059; GO:0004060; GO:0005737; GO:0048066; GO:0042420; GO:0030187; GO:0046334; GO:0045187; GO:0042429; GO:0030431 "aralkylamine N-acetyltransferase activity; arylamine N-acetyltransferase activity; cytoplasm; developmental pigmentation; dopamine catabolic process; melatonin biosynthetic process; octopamine catabolic process; regulation of circadian sleep/wake cycle, sleep; serotonin catabolic process; sleep" IPR016181; IPR000182; Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2. Dopamine N-acetyltransferase (EC 2.3.1.87) (Arylalkylamine N-acetyltransferase) (aaNAT1) Dat NAT1 CG3318 Drosophila melanogaster (Fruit fly) TR30698_c0_g2_i1 P46870 KLP1_CHLRE 4.00E-24 GO:0005524; GO:0030030; GO:0005929; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0007018 ATP binding; cell projection organization; cilium; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KLP1 KLP1 Chlamydomonas reinhardtii (Chlamydomonas smithii) TR30698_c2_g1_i1 Q9WV04 KIF9_MOUSE 2.00E-49 GO:0005524; GO:0005829; GO:0005871; GO:0005874; GO:0003777; GO:0007018 ATP binding; cytosol; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF9 Kif9 Mus musculus (Mouse) TR30699_c2_g1_i2 Q9UJN7 ZN391_HUMAN 3.00E-07 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 391 ZNF391 Homo sapiens (Human) TR3070_c0_g1_i1 Q6PG95 CRML_MOUSE 9.00E-10 GO:0003677; GO:0003682; GO:0005634 DNA binding; chromatin binding; nucleus IPR001005; IPR017884; Protein cramped-like (Hematological and neurological expressed 1-like protein) Cramp1l Hn1l Kiaa1426 Tce4 Mus musculus (Mouse) TR30700_c0_g1_i2 P24347 MMP11_HUMAN 6.00E-25 GO:0005796; GO:0005509; GO:0030574; GO:0022617; GO:0004222; GO:0007275; GO:0005578; GO:0006508; GO:0008270 Golgi lumen; calcium ion binding; collagen catabolic process; extracellular matrix disassembly; metalloendopeptidase activity; multicellular organismal development; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000585; IPR018487; IPR018486; IPR024079; IPR001818; IPR021190; IPR016293; IPR021158; IPR006026; Stromelysin-3 (SL-3) (ST3) (EC 3.4.24.-) (Matrix metalloproteinase-11) (MMP-11) MMP11 STMY3 Homo sapiens (Human) TR30700_c0_g2_i1 O55761 165R_IIV6 2.00E-10 GO:0031012; GO:0004222; GO:0006508; GO:0008270 extracellular matrix; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR001818; IPR021190; IPR006026; Putative metalloproteinase 165R (EC 3.4.24.-) IIV6-165R Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) TR30700_c0_g3_i1 Q0E587 MMP_SFAVA 4.00E-06 GO:0031012; GO:0004222; GO:0006508; GO:0008270 extracellular matrix; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR001818; IPR021190; IPR006026; Putative matrix metalloproteinase (EC 3.4.24.-) ORF14 Spodoptera frugiperda ascovirus 1a (SfAV-1a) TR30702_c2_g1_i1 Q8N695 SC5A8_HUMAN 4.00E-95 GO:0016324; GO:0006915; GO:0016021; GO:0006811; GO:0005886; GO:0006814; GO:0015293; GO:0055085 apical plasma membrane; apoptotic process; integral to membrane; ion transport; plasma membrane; sodium ion transport; symporter activity; transmembrane transport IPR001734; IPR019900; Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8) SLC5A8 AIT SMCT SMCT1 Homo sapiens (Human) TR30702_c2_g1_i3 Q8N695 SC5A8_HUMAN 2.00E-96 GO:0016324; GO:0006915; GO:0016021; GO:0006811; GO:0005886; GO:0006814; GO:0015293; GO:0055085 apical plasma membrane; apoptotic process; integral to membrane; ion transport; plasma membrane; sodium ion transport; symporter activity; transmembrane transport IPR001734; IPR019900; Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8) SLC5A8 AIT SMCT SMCT1 Homo sapiens (Human) TR30703_c0_g2_i1 Q7YZH1 RNO_DROME 5.00E-27 GO:0042051; GO:0042059; GO:0005634; GO:0008270 compound eye photoreceptor development; negative regulation of epidermal growth factor receptor signaling pathway; nucleus; zinc ion binding IPR019542; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; PHD finger protein rhinoceros rno CG7036 Drosophila melanogaster (Fruit fly) TR30703_c1_g1_i1 O94880 PHF14_HUMAN 5.00E-83 GO:0008270 zinc ion binding IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; PHD finger protein 14 PHF14 KIAA0783 Homo sapiens (Human) TR30704_c1_g1_i1 Q9VQ89 MIO_DROME 6.00E-06 GO:0006302; GO:0001674; GO:0007275; GO:0009994; GO:0030716; GO:0043234; GO:0040020 double-strand break repair; female germ cell nucleus; multicellular organismal development; oocyte differentiation; oocyte fate determination; protein complex; regulation of meiosis IPR015943; IPR001680; IPR017986; WD repeat-containing protein mio (Missing oocyte protein) mio CG7074 Drosophila melanogaster (Fruit fly) TR30704_c1_g2_i1 O14186 YDSB_SCHPO 3.00E-37 GO:0005829; GO:0005778; GO:0043234 cytosol; peroxisomal membrane; protein complex IPR015943; IPR001680; IPR019775; IPR017986; IPR013083; Uncharacterized WD repeat-containing protein C4F8.11 SPAC4F8.11 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR30704_c1_g2_i2 Q7ZVL2 WDR24_DANRE 3.00E-143 IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 24 wdr24 Danio rerio (Zebrafish) (Brachydanio rerio) TR30709_c0_g2_i2 A1L3F5 CMIP_XENLA 7.00E-114 GO:0005737; GO:0005634; GO:0005543 cytoplasm; nucleus; phospholipid binding IPR001849; C-Maf-inducing protein (c-Mip) cmip Xenopus laevis (African clawed frog) TR30709_c0_g2_i4 A1L3F5 CMIP_XENLA 1.00E-113 GO:0005737; GO:0005634; GO:0005543 cytoplasm; nucleus; phospholipid binding IPR001849; C-Maf-inducing protein (c-Mip) cmip Xenopus laevis (African clawed frog) TR30710_c1_g1_i1 Q00651 ITA4_MOUSE 8.00E-55 GO:0001974; GO:0016477; GO:0005911; GO:0007160; GO:0060710; GO:0009897; GO:0060324; GO:0001968; GO:0007157; GO:0008305; GO:0007229; GO:0007159; GO:0060485; GO:0046872; GO:0061032 blood vessel remodeling; cell migration; cell-cell junction; cell-matrix adhesion; chorio-allantoic fusion; external side of plasma membrane; face development; fibronectin binding; heterophilic cell-cell adhesion; integrin complex; integrin-mediated signaling pathway; leukocyte cell-cell adhesion; mesenchyme development; metal ion binding; visceral serous pericardium development IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (Lymphocyte Peyer patch adhesion molecules subunit alpha) (LPAM subunit alpha) (VLA-4 subunit alpha) (CD antigen CD49d) Itga4 Mus musculus (Mouse) TR30712_c0_g1_i1 P23786 CPT2_HUMAN 0 GO:0004095; GO:0006853; GO:0006635; GO:0005743; GO:0005730 carnitine O-palmitoyltransferase activity; carnitine shuttle; fatty acid beta-oxidation; mitochondrial inner membrane; nucleolus IPR000542; Lipid metabolism; fatty acid beta-oxidation. "Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II) (CPT II)" CPT2 CPT1 Homo sapiens (Human) TR30713_c0_g1_i1 Q60857 SC6A4_MOUSE 4.00E-99 GO:0051015; GO:0048854; GO:0071321; GO:0071310; GO:0071300; GO:0007623; GO:0019811; GO:0005829; GO:0012505; GO:0010008; GO:0005887; GO:0045121; GO:0007613; GO:0021941; GO:0045665; GO:0046621; GO:0032227; GO:0043005; GO:0005886; GO:0045787; GO:0010628; GO:0051260; GO:0051259; GO:0042493; GO:0032355; GO:0001666; GO:0007584; GO:0009636; GO:0051610; GO:0005335; GO:0035176; GO:0042713; GO:0021794; GO:0042310 "actin filament binding; brain morphogenesis; cellular response to cGMP; cellular response to organic substance; cellular response to retinoic acid; circadian rhythm; cocaine binding; cytosol; endomembrane system; endosome membrane; integral to plasma membrane; membrane raft; memory; negative regulation of cerebellar granule cell precursor proliferation; negative regulation of neuron differentiation; negative regulation of organ growth; negative regulation of synaptic transmission, dopaminergic; neuron projection; plasma membrane; positive regulation of cell cycle; positive regulation of gene expression; protein homooligomerization; protein oligomerization; response to drug; response to estradiol stimulus; response to hypoxia; response to nutrient; response to toxic substance; serotonin uptake; serotonin:sodium symporter activity; social behavior; sperm ejaculation; thalamus development; vasoconstriction" IPR000175; IPR013086; Sodium-dependent serotonin transporter (5HT transporter) (5HTT) (Solute carrier family 6 member 4) Slc6a4 Htt Sert Mus musculus (Mouse) TR30713_c0_g1_i2 O34383 YOCR_BACSU 3.00E-12 GO:0016021; GO:0005328; GO:0005886 integral to membrane; neurotransmitter:sodium symporter activity; plasma membrane IPR000175; Uncharacterized sodium-dependent transporter YocR yocR BSU19340 Bacillus subtilis (strain 168) TR30713_c0_g2_i1 P51905 SC6A4_DROME 1.00E-102 GO:0043679; GO:0005261; GO:0016021; GO:0005328; GO:0006909; GO:0015222; GO:0051610 axon terminus; cation channel activity; integral to membrane; neurotransmitter:sodium symporter activity; phagocytosis; serotonin transmembrane transporter activity; serotonin uptake IPR000175; Sodium-dependent serotonin transporter (5HT transporter) (5HTT) (Cocaine-sensitive serotonin transporter) (dSERT1) SerT CG4545 Drosophila melanogaster (Fruit fly) TR30715_c0_g1_i1 P21520 SCA_DROME 3.00E-47 GO:0007219; GO:0007460; GO:0005576; GO:0016321; GO:0008587; GO:0005770; GO:0046331; GO:0016318; GO:0045468; GO:0097305; GO:0004871 Notch signaling pathway; R8 cell fate commitment; extracellular region; female meiosis chromosome segregation; imaginal disc-derived wing margin morphogenesis; late endosome; lateral inhibition; ommatidial rotation; regulation of R8 cell spacing in compound eye; response to alcohol; signal transducer activity IPR014716; IPR014715; IPR002181; IPR020837; Protein scabrous sca CG17579 Drosophila melanogaster (Fruit fly) TR30715_c0_g1_i3 Q00546 TENR_CHICK 5.00E-45 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR013032; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin-R (TN-R) (Restrictin) TNR Gallus gallus (Chicken) TR30716_c2_g1_i2 Q8WZ42 TITIN_HUMAN 4.00E-06 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR30719_c5_g4_i1 P11928 OAS1A_MOUSE 4.00E-35 GO:0001730; GO:0005524; GO:0051607; GO:0003725; GO:0005783; GO:0045087; GO:0046872; GO:0005739; GO:0005634; GO:0006164; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; defense response to virus; double-stranded RNA binding; endoplasmic reticulum; innate immune response; metal ion binding; mitochondrion; nucleus; purine nucleotide biosynthetic process; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 1A ((2-5')oligo(A) synthase 1A) (2-5A synthase 1A) (EC 2.7.7.84) (p42 OAS) Oas1a Oias1 Mus musculus (Mouse) TR30719_c5_g4_i3 Q15646 OASL_HUMAN 8.00E-14 GO:0005524; GO:0003677; GO:0005829; GO:0051607; GO:0003725; GO:0060333; GO:0045071; GO:0005730; GO:0009615; GO:0046966; GO:0016740; GO:0060337 ATP binding; DNA binding; cytosol; defense response to virus; double-stranded RNA binding; interferon-gamma-mediated signaling pathway; negative regulation of viral genome replication; nucleolus; response to virus; thyroid hormone receptor binding; transferase activity; type I interferon-mediated signaling pathway IPR006117; IPR006116; IPR018952; IPR026774; IPR000626; 2'-5'-oligoadenylate synthase-like protein (2'-5'-OAS-related protein) (2'-5'-OAS-RP) (59 kDa 2'-5'-oligoadenylate synthase-like protein) (Thyroid receptor-interacting protein 14) (TR-interacting protein 14) (TRIP-14) (p59 OASL) (p59OASL) OASL TRIP14 Homo sapiens (Human) TR3072_c0_g1_i1 Q8K4Q8 COL12_MOUSE 9.00E-08 GO:0030246; GO:0005581; GO:0006955; GO:0016021; GO:0030169; GO:0046872; GO:0006910; GO:0008329 "carbohydrate binding; collagen; immune response; integral to membrane; low-density lipoprotein particle binding; metal ion binding; phagocytosis, recognition; signaling pattern recognition receptor activity" IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-12 (Collectin placenta protein 1) (CL-P1) (Scavenger receptor with C-type lectin) Colec12 Clp1 Srcl Mus musculus (Mouse) TR3072_c0_g2_i1 P13608 PGCA_BOVIN 3.00E-07 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 Q9UNA0; P49747 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Bos taurus (Bovine) TR30722_c1_g1_i1 Q9I8C7 ACH10_CHICK 8.00E-23 GO:0004889; GO:0005262; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; calcium channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 Gallus gallus (Chicken) TR30723_c2_g1_i1 O88319 NTR1_MOUSE 2.00E-06 GO:0016492; GO:0008344; GO:0005887 G-protein coupled neurotensin receptor activity; adult locomotory behavior; integral to plasma membrane IPR000276; IPR017452; IPR003985; IPR003984; Neurotensin receptor type 1 (NT-R-1) (NTR1) Ntsr1 Ntsr Mus musculus (Mouse) TR30727_c0_g1_i1 Q0V9S9 CC135_XENTR 3.00E-62 GO:0030154; GO:0001539; GO:0005929; GO:0007283 cell differentiation; ciliary or bacterial-type flagellar motility; cilium; spermatogenesis Coiled-coil domain-containing protein lobo homolog (Coiled-coil domain-containing protein 135) ccdc135 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30730_c0_g1_i5 Q9WVF8 TUSC2_MOUSE 4.00E-15 GO:0048469; GO:0071609; GO:0006954; GO:0032618; GO:0005739; GO:0001779; GO:0051881; GO:2000377 cell maturation; chemokine (C-C motif) ligand 5 production; inflammatory response; interleukin-15 production; mitochondrion; natural killer cell differentiation; regulation of mitochondrial membrane potential; regulation of reactive oxygen species metabolic process Tumor suppressor candidate 2 (Fusion 1 protein) (Fus-1 protein) (PDGFA-associated protein 2) Tusc2 Fus1 Lgcc Pdap2 Mus musculus (Mouse) TR30732_c0_g2_i1 P21328 RTJK_DROME 2.00E-11 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) TR30732_c1_g2_i1 Q10126 YSM6_CAEEL 6.00E-07 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR000477; Putative uncharacterized transposon-derived protein F52C9.6 F52C9.6 Caenorhabditis elegans TR30735_c0_g1_i2 P81546 TIMP1_CANFA 7.00E-10 GO:0043249; GO:0005576; GO:0046872; GO:0008191 erythrocyte maturation; extracellular region; metal ion binding; metalloendopeptidase inhibitor activity IPR001134; IPR001820; IPR008993; IPR015611; IPR027465; Metalloproteinase inhibitor 1 (Tissue inhibitor of metalloproteinases 1) (TIMP-1) TIMP1 Canis familiaris (Dog) (Canis lupus familiaris) TR30737_c2_g1_i1 Q8IVH2 FOXP4_HUMAN 4.00E-84 GO:0048617; GO:0007507; GO:0046872; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "embryonic foregut morphogenesis; heart development; metal ion binding; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; IPR015880; Forkhead box protein P4 (Fork head-related protein-like A) FOXP4 FKHLA Homo sapiens (Human) TR30738_c0_g4_i1 O97772 CCKAR_RABIT 5.00E-06 GO:0004951; GO:0038188; GO:0016021; GO:0005886 cholecystokinin receptor activity; cholecystokinin signaling pathway; integral to membrane; plasma membrane IPR009126; IPR000596; IPR015276; IPR000276; IPR017452; Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR Oryctolagus cuniculus (Rabbit) TR30741_c0_g2_i2 Q8VI33 TAF9_MOUSE 2.00E-66 GO:0003677; GO:0006352; GO:0071339; GO:0000125; GO:0030914; GO:0043966; GO:0004402; GO:0043066; GO:0032435; GO:0030307; GO:0060760; GO:0045944; GO:0070761; GO:0050821; GO:0070555; GO:0003713; GO:0005669; GO:0033276; GO:0044212 "DNA binding; DNA-dependent transcription, initiation; MLL1 complex; PCAF complex; STAGA complex; histone H3 acetylation; histone acetyltransferase activity; negative regulation of apoptotic process; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of cell growth; positive regulation of response to cytokine stimulus; positive regulation of transcription from RNA polymerase II promoter; pre-snoRNP complex; protein stabilization; response to interleukin-1; transcription coactivator activity; transcription factor TFIID complex; transcription factor TFTC complex; transcription regulatory region DNA binding" IPR009072; IPR003162; Transcription initiation factor TFIID subunit 9 (RNA polymerase II TBP-associated factor subunit G) (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII31) (Transcription initiation factor TFIID 32 kDa subunit) (TAFII-32) (TAFII32) Taf9 Taf2g Mus musculus (Mouse) TR30742_c0_g1_i1 Q28GP0 CD033_XENTR 6.00E-32 UPF0462 protein C4orf33 homolog TEgg072n04.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30742_c0_g1_i3 Q8BGN2 CD033_MOUSE 9.00E-44 UPF0462 protein C4orf33 homolog D3Ertd751e Mus musculus (Mouse) TR30744_c10_g7_i1 P28173 PUR1_CHICK 9.00E-105 GO:0006189; GO:0051539; GO:0004044; GO:0005829; GO:0006541; GO:0046872; GO:0009116; GO:0009113; GO:0006144 "'de novo' IMP biosynthetic process; 4 iron, 4 sulfur cluster binding; amidophosphoribosyltransferase activity; cytosol; glutamine metabolic process; metal ion binding; nucleoside metabolic process; purine nucleobase biosynthetic process; purine nucleobase metabolic process" IPR005854; IPR017932; IPR000583; IPR000836; Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT) PPAT GPAT Gallus gallus (Chicken) TR30744_c7_g1_i1 Q2TBI2 THAP4_BOVIN 4.00E-08 GO:0003677; GO:0046872 DNA binding; metal ion binding IPR011038; IPR014878; IPR006612; THAP domain-containing protein 4 THAP4 Bos taurus (Bovine) TR30744_c7_g1_i2 Q9H0W7 THAP2_HUMAN 4.00E-11 GO:0003677; GO:0046872; GO:0005730 DNA binding; metal ion binding; nucleolus IPR026521; IPR006612; THAP domain-containing protein 2 THAP2 Homo sapiens (Human) TR30744_c8_g1_i1 Q06203 PUR1_HUMAN 8.00E-105 GO:0006189; GO:0051539; GO:0000082; GO:0004044; GO:0035690; GO:0032869; GO:0005829; GO:0006543; GO:0001822; GO:0007595; GO:0060135; GO:0046872; GO:0009116; GO:0031100; GO:0051289; GO:0009113; GO:0006144; GO:0006164; GO:0009168 "'de novo' IMP biosynthetic process; 4 iron, 4 sulfur cluster binding; G1/S transition of mitotic cell cycle; amidophosphoribosyltransferase activity; cellular response to drug; cellular response to insulin stimulus; cytosol; glutamine catabolic process; kidney development; lactation; maternal process involved in female pregnancy; metal ion binding; nucleoside metabolic process; organ regeneration; protein homotetramerization; purine nucleobase biosynthetic process; purine nucleobase metabolic process; purine nucleotide biosynthetic process; purine ribonucleoside monophosphate biosynthetic process" IPR005854; IPR017932; IPR000583; IPR000836; Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT) PPAT GPAT Homo sapiens (Human) TR30745_c1_g1_i1 Q91WA3 HDA11_MOUSE 3.00E-141 GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0005737; GO:0070932; GO:0070933; GO:0004407; GO:0000118; GO:0005886; GO:0006355; GO:0008134; GO:0006351 "NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); cytoplasm; histone H3 deacetylation; histone H4 deacetylation; histone deacetylase activity; histone deacetylase complex; plasma membrane; regulation of transcription, DNA-dependent; transcription factor binding; transcription, DNA-dependent" IPR000286; IPR023801; Histone deacetylase 11 (HD11) (EC 3.5.1.98) Hdac11 Mus musculus (Mouse) TR30745_c1_g1_i2 P28606 Y1628_SYNP2 1.00E-28 GO:0016787 hydrolase activity IPR000286; IPR023801; Uncharacterized protein SYNPCC7002_A1628 SYNPCC7002_A1628 Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) TR30752_c1_g1_i1 Q5R6Q2 STX6_PONAB 5.00E-85 GO:0000139; GO:0048193; GO:0016021; GO:0006886 Golgi membrane; Golgi vesicle transport; integral to membrane; intracellular protein transport IPR015260; IPR006012; IPR010989; IPR000727; Syntaxin-6 STX6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR30754_c0_g1_i1 Q08DY9 CASP3_BOVIN 9.00E-29 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Bos taurus (Bovine) TR30755_c0_g4_i1 P40142 TKT_MOUSE 0 GO:0046872; GO:0040008; GO:0004802 metal ion binding; regulation of growth; transketolase activity IPR009014; IPR005475; IPR020826; IPR005476; IPR005474; Transketolase (TK) (EC 2.2.1.1) (P68) Tkt Mus musculus (Mouse) TR30755_c0_g4_i2 Q9D4D4 TKTL2_MOUSE 0 GO:0046872; GO:0004802 metal ion binding; transketolase activity IPR009014; IPR005475; IPR020826; IPR005476; IPR005474; Transketolase-like protein 2 (EC 2.2.1.1) Tktl2 Mus musculus (Mouse) TR30756_c2_g2_i1 Q8BUH7 RNF26_MOUSE 2.00E-09 GO:0016021; GO:0008270 integral to membrane; zinc ion binding IPR001841; IPR013083; Ring finger protein 26 Rnf26 Mus musculus (Mouse) TR30756_c2_g2_i3 Q8BUH7 RNF26_MOUSE 3.00E-10 GO:0016021; GO:0008270 integral to membrane; zinc ion binding IPR001841; IPR013083; Ring finger protein 26 Rnf26 Mus musculus (Mouse) TR30757_c0_g1_i1 Q96T60 PNKP_HUMAN 4.00E-85 GO:0005524; GO:0046404; GO:0042769; GO:0006261; GO:0003684; GO:0003690; GO:0004519; GO:0005730; GO:0019201; GO:0000718; GO:0046403; GO:0006979; GO:0009314 P18887; Q13426 "ATP binding; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; DNA damage response, detection of DNA damage; DNA-dependent DNA replication; damaged DNA binding; double-stranded DNA binding; endonuclease activity; nucleolus; nucleotide kinase activity; nucleotide-excision repair, DNA damage removal; polynucleotide 3'-phosphatase activity; response to oxidative stress; response to radiation" IPR000253; IPR023214; IPR006549; IPR027417; IPR013954; IPR006550; IPR006551; IPR008984; Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] PNKP Homo sapiens (Human) TR30758_c2_g3_i4 Q9ESN4 C1QL3_MOUSE 9.00E-15 GO:0005581; GO:0005576; GO:0050807 collagen; extracellular region; regulation of synapse organization IPR001073; IPR008160; IPR008983; Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13) (CTRP13) (Gliacolin) C1ql3 C1ql Ctrp13 Mus musculus (Mouse) TR30758_c3_g1_i1 P02746 C1QB_HUMAN 2.00E-07 GO:0005581; GO:0006958; GO:0005602; GO:0045087; GO:0048839 P02745 "collagen; complement activation, classical pathway; complement component C1 complex; innate immune response; inner ear development" IPR001073; IPR008160; IPR008983; Complement C1q subcomponent subunit B C1QB Homo sapiens (Human) TR30758_c3_g4_i1 Q5RJ80 CAPR2_DANRE 2.00E-07 GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:2000055; GO:0090263; GO:0050775; GO:0061003; GO:0040008 RNA binding; cytoplasm; dorsal/ventral pattern formation; negative regulation of translation; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of dendrite morphogenesis; positive regulation of dendritic spine morphogenesis; regulation of growth IPR001073; IPR008983; Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR30759_c0_g2_i1 O95835 LATS1_HUMAN 0 GO:0005524; GO:0000086; GO:0051301; GO:0051220; GO:0005829; GO:0035329; GO:0009755; GO:0030216; GO:0000287; GO:0005815; GO:0007067; GO:0090090; GO:0045736; GO:0033138; GO:0004674; GO:0030833; GO:0000819; GO:0000922 P06493; P53667; Q9H8S9; Q7L9L4; O60285; Q9GZV5; P46937; Q15942 ATP binding; G2/M transition of mitotic cell cycle; cell division; cytoplasmic sequestering of protein; cytosol; hippo signaling cascade; hormone-mediated signaling pathway; keratinocyte differentiation; magnesium ion binding; microtubule organizing center; mitosis; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of peptidyl-serine phosphorylation; protein serine/threonine kinase activity; regulation of actin filament polymerization; sister chromatid segregation; spindle pole IPR000961; IPR011009; IPR000719; IPR002290; IPR008271; IPR009060; IPR015940; IPR000449; Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) LATS1 WARTS Homo sapiens (Human) TR30764_c0_g1_i1 Q9BZQ6 EDEM3_HUMAN 9.00E-23 GO:0005509; GO:0005788; GO:0005789; GO:0006516; GO:0004569; GO:0004571; GO:0043687; GO:0043161; GO:0018279; GO:0006457; GO:0006986 "calcium ion binding; endoplasmic reticulum lumen; endoplasmic reticulum membrane; glycoprotein catabolic process; glycoprotein endo-alpha-1,2-mannosidase activity; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; post-translational protein modification; proteasomal ubiquitin-dependent protein catabolic process; protein N-linked glycosylation via asparagine; protein folding; response to unfolded protein" IPR001382; IPR003137; "ER degradation-enhancing alpha-mannosidase-like protein 3 (EC 3.2.1.113) (Alpha-1,2-mannosidase EDEM3)" EDEM3 C1orf22 Homo sapiens (Human) TR30766_c0_g1_i1 O28972 Y1297_ARCFU 6.00E-11 GO:0005524; GO:0017111 ATP binding; nucleoside-triphosphatase activity IPR003593; IPR005938; IPR009010; IPR003959; IPR003960; IPR004201; IPR003338; IPR027417; IPR015415; Cell division cycle protein 48 homolog AF_1297 AF_1297 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) TR30766_c0_g1_i2 Q0VD48 VPS4B_BOVIN 1.00E-45 GO:0005524; GO:0016887; GO:0007049; GO:0051301; GO:0005829; GO:0005769; GO:0007032; GO:0032510; GO:0032367; GO:0031902; GO:0005764; GO:0005634; GO:0006813; GO:0015031; GO:0033993; GO:0005774 ATP binding; ATPase activity; cell cycle; cell division; cytosol; early endosome; endosome organization; endosome to lysosome transport via multivesicular body sorting pathway; intracellular cholesterol transport; late endosome membrane; lysosome; nucleus; potassium ion transport; protein transport; response to lipid; vacuolar membrane IPR003593; IPR003959; IPR003960; IPR007330; IPR027417; IPR015415; Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) VPS4B Bos taurus (Bovine) TR30766_c0_g2_i1 Q4R7L3 PRS6B_MACFA 6.00E-10 GO:0005524; GO:0005737; GO:0017111; GO:0005634; GO:0022624; GO:0030163 ATP binding; cytoplasm; nucleoside-triphosphatase activity; nucleus; proteasome accessory complex; protein catabolic process IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (Proteasome 26S subunit ATPase 4) PSMC4 QtsA-14940 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR30766_c0_g3_i3 Q3B8D5 KATL2_XENLA 5.00E-14 GO:0005524; GO:0005737; GO:0005874; GO:0051013; GO:0008568 ATP binding; cytoplasm; microtubule; microtubule severing; microtubule-severing ATPase activity IPR003593; IPR003959; IPR027497; IPR006594; IPR013720; IPR027417; Katanin p60 ATPase-containing subunit A-like 2 (Katanin p60 subunit A-like 2) (EC 3.6.4.3) (p60 katanin-like 2) katnal2 Xenopus laevis (African clawed frog) TR30769_c0_g1_i1 Q7Z5L0 VMO1_HUMAN 8.00E-20 GO:0005576; GO:0030704 extracellular region; vitelline membrane formation IPR005515; Vitelline membrane outer layer protein 1 homolog VMO1 UNQ6350/PRO21055 Homo sapiens (Human) TR30770_c5_g2_i1 Q6DFV8 VWDE_MOUSE 8.00E-25 GO:0005576 extracellular region IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) TR30770_c5_g3_i1 Q29116 TENA_PIG 9.00E-07 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (P230) (Tenascin-C) (TN-C) TNC HXB Sus scrofa (Pig) TR30770_c5_g6_i1 P22105 TENX_HUMAN 9.00E-06 GO:0030036; GO:0007155; GO:0016337; GO:0007160; GO:0030199; GO:0032963; GO:0048251; GO:0043206; GO:0005615; GO:0006631; GO:0008201; GO:0005178; GO:0005622; GO:0005578; GO:0043506; GO:0006641 actin cytoskeleton organization; cell adhesion; cell-cell adhesion; cell-matrix adhesion; collagen fibril organization; collagen metabolic process; elastic fiber assembly; extracellular fibril organization; extracellular space; fatty acid metabolic process; heparin binding; integrin binding; intracellular; proteinaceous extracellular matrix; regulation of JUN kinase activity; triglyceride metabolic process IPR000742; IPR013032; IPR014716; IPR014715; IPR002181; IPR020837; IPR003961; IPR013783; Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) TR30770_c5_g7_i1 Q6DFV8 VWDE_MOUSE 3.00E-19 GO:0005576 extracellular region IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) TR30775_c0_g1_i1 P41250 SYG_HUMAN 0 GO:0005524; GO:0008219; GO:0005829; GO:0015966; GO:0004820; GO:0006426; GO:0005759; GO:0046983; GO:0030141; GO:0006418 ATP binding; cell death; cytosol; diadenosine tetraphosphate biosynthetic process; glycine-tRNA ligase activity; glycyl-tRNA aminoacylation; mitochondrial matrix; protein dimerization activity; secretory granule; tRNA aminoacylation for protein translation IPR002314; IPR006195; IPR004154; IPR027031; IPR009068; IPR002315; IPR000738; Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (AP-4-A synthetase) (Glycyl-tRNA synthetase) (GlyRS) GARS Homo sapiens (Human) TR30775_c0_g1_i2 Q04451 SYG_BOMMO 0 GO:0005524; GO:0005737; GO:0015966; GO:0004820; GO:0006426; GO:0046983 ATP binding; cytoplasm; diadenosine tetraphosphate biosynthetic process; glycine-tRNA ligase activity; glycyl-tRNA aminoacylation; protein dimerization activity IPR002314; IPR006195; IPR004154; IPR027031; IPR009068; IPR002315; IPR000738; Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (AP-4-A synthetase) (Glycyl-tRNA synthetase) (GlyRS) Bombyx mori (Silk moth) TR30775_c1_g1_i1 Q4V7F3 OSGP2_RAT 4.00E-68 GO:0005739; GO:0008033 mitochondrion; tRNA processing IPR000905; IPR017861; "Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial (EC 2.3.1.-) (O-sialoglycoprotein endopeptidase-like protein 1) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1) (tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1)" Osgepl1 Rattus norvegicus (Rat) TR30775_c1_g3_i1 Q6PEB4 OSGP2_MOUSE 6.00E-69 GO:0005739; GO:0008033 mitochondrion; tRNA processing IPR000905; IPR017861; "Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial (EC 2.3.1.-) (O-sialoglycoprotein endopeptidase-like protein 1) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1) (tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1)" Osgepl1 Mus musculus (Mouse) TR30780_c5_g1_i1 Q9D1E8 PLCE_MOUSE 2.00E-43 GO:0003841; GO:0016024; GO:0006639; GO:0005789; GO:0016021; GO:0005739; GO:0005635 1-acylglycerol-3-phosphate O-acyltransferase activity; CDP-diacylglycerol biosynthetic process; acylglycerol metabolic process; endoplasmic reticulum membrane; integral to membrane; mitochondrion; nuclear envelope IPR002123; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 5) (1-AGP acyltransferase 5) (1-AGPAT 5) (Lysophosphatidic acid acyltransferase epsilon) (LPAAT-epsilon) Agpat5 D8Ertd319e Mus musculus (Mouse) TR30781_c1_g2_i2 Q09003 COIL_XENLA 2.00E-13 GO:0071601 sphere organelle IPR024822; Coilin (Sphere organelles protein SPH-1) (Sphere protein 1) coil sph1 Xenopus laevis (African clawed frog) TR30789_c0_g1_i1 Q96Q11 TRNT1_HUMAN 1.00E-113 GO:0005524; GO:0052929; GO:0052928; GO:0052927; GO:0005813; GO:0005739; GO:0006626; GO:0042780; GO:0001680; GO:0004810; GO:0000049; GO:0009022 ATP binding; ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity; CTP:3'-cytidine-tRNA cytidylyltransferase activity; CTP:tRNA cytidylyltransferase activity; centrosome; mitochondrion; protein targeting to mitochondrion; tRNA 3'-end processing; tRNA 3'-terminal CCA addition; tRNA adenylyltransferase activity; tRNA binding; tRNA nucleotidyltransferase activity IPR002646; IPR026973; "CCA tRNA nucleotidyltransferase 1, mitochondrial (EC 2.7.7.72) (Mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt CCA-adding enzyme) (mt tRNA CCA-diphosphorylase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA adenylyltransferase)" TRNT1 CGI-47 Homo sapiens (Human) TR30790_c1_g1_i5 Q3UI66 CCD34_MOUSE 3.00E-17 Coiled-coil domain-containing protein 34 Ccdc34 Mus musculus (Mouse) TR30790_c1_g3_i1 Q62665 LEG8_RAT 4.00E-48 GO:0030246; GO:0005737 carbohydrate binding; cytoplasm IPR008985; IPR013320; IPR001079; Galectin-8 (Gal-8) (30 kDa S-type lectin) (RL-30) Lgals8 Rattus norvegicus (Rat) TR30791_c0_g1_i1 Q921Y2 IMP3_MOUSE 8.00E-78 GO:0005730; GO:0019843; GO:0006364; GO:0030529; GO:0030519 nucleolus; rRNA binding; rRNA processing; ribonucleoprotein complex; snoRNP binding IPR022801; IPR001912; IPR002942; U3 small nucleolar ribonucleoprotein protein IMP3 (U3 snoRNP protein IMP3) Imp3 Mus musculus (Mouse) TR30794_c0_g1_i2 Q02960 MIF_CHICK 3.00E-33 GO:0030330; GO:0007569; GO:0008283; GO:0009986; GO:0007166; GO:0042056; GO:0005737; GO:0004167; GO:0005615; GO:0006954; GO:0045087; GO:0043518; GO:0090344; GO:0071157; GO:0032269; GO:0010629; GO:1902166; GO:0002906; GO:0033033; GO:0050178; GO:0030890; GO:0070374; GO:0043406; GO:0090238; GO:2000343; GO:0050715; GO:0048146; GO:0031666; GO:0061081; GO:0033138; GO:0050731; GO:0061078; GO:0010739; GO:0001516; GO:0070207 "DNA damage response, signal transduction by p53 class mediator; cell aging; cell proliferation; cell surface; cell surface receptor signaling pathway; chemoattractant activity; cytoplasm; dopachrome isomerase activity; extracellular space; inflammatory response; innate immune response; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of cell aging; negative regulation of cell cycle arrest; negative regulation of cellular protein metabolic process; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of mature B cell apoptotic process; negative regulation of myeloid cell apoptotic process; phenylpyruvate tautomerase activity; positive regulation of B cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAP kinase activity; positive regulation of arachidonic acid secretion; positive regulation of chemokine (C-X-C motif) ligand 2 production; positive regulation of cytokine secretion; positive regulation of fibroblast proliferation; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of myeloid leukocyte cytokine production involved in immune response; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of prostaglandin secretion involved in immune response; positive regulation of protein kinase A signaling cascade; prostaglandin biosynthetic process; protein homotrimerization" IPR001398; IPR019829; IPR014347; Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) MIF Gallus gallus (Chicken) TR30794_c0_g1_i4 Q5ZMG0 DOPD_CHICK 6.00E-15 GO:0033981; GO:0005737; GO:0042438 D-dopachrome decarboxylase activity; cytoplasm; melanin biosynthetic process IPR001398; IPR019829; IPR014347; D-dopachrome decarboxylase (EC 4.1.1.84) (D-dopachrome tautomerase) DDT RCJMB04_2c16 Gallus gallus (Chicken) TR30795_c0_g1_i1 P06280 AGAL_HUMAN 3.00E-109 GO:0005794; GO:0004557; GO:0005576; GO:0016936; GO:0016139; GO:0046477; GO:0043202; GO:0045019; GO:0051001; GO:0009311; GO:0042803; GO:0052692; GO:0005102; GO:0044281 Golgi apparatus; alpha-galactosidase activity; extracellular region; galactoside binding; glycoside catabolic process; glycosylceramide catabolic process; lysosomal lumen; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; oligosaccharide metabolic process; protein homodimerization activity; raffinose alpha-galactosidase activity; receptor binding; small molecule metabolic process IPR013785; IPR013780; IPR002241; IPR000111; IPR017853; Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Melibiase) (Agalsidase) GLA Homo sapiens (Human) TR30798_c0_g1_i2 Q8IYA7 MKX_HUMAN 3.00E-33 GO:0030199; GO:0007517; GO:0045662; GO:0000122; GO:0005634; GO:0032967; GO:0010628; GO:0043565; GO:0000981; GO:0035990; GO:0002932 collagen fibril organization; muscle organ development; negative regulation of myoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of collagen biosynthetic process; positive regulation of gene expression; sequence-specific DNA binding; sequence-specific DNA binding RNA polymerase II transcription factor activity; tendon cell differentiation; tendon sheath development IPR017970; IPR001356; IPR008422; IPR009057; Homeobox protein Mohawk MKX C10orf48 IRXL1 Homo sapiens (Human) TR30802_c1_g1_i1 Q95LM1 UBE2U_MACFA 1.00E-38 GO:0005524; GO:0004842 ATP binding; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 U (EC 6.3.2.19) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U) UBE2U QtsA-20104 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR30802_c1_g1_i2 Q5VVX9 UBE2U_HUMAN 1.00E-39 GO:0005524; GO:0004842 ATP binding; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 U (EC 6.3.2.19) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U) UBE2U Homo sapiens (Human) TR30803_c0_g1_i1 Q5R5L7 ARRD3_PONAB 3.00E-30 GO:0005737 cytoplasm IPR011021; IPR011022; IPR014756; Arrestin domain-containing protein 3 ARRDC3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR30803_c0_g1_i2 Q8TBH0 ARRD2_HUMAN 5.00E-21 GO:0031410; GO:0005886; GO:0007165 cytoplasmic vesicle; plasma membrane; signal transduction IPR011021; IPR014752; IPR011022; IPR014756; Arrestin domain-containing protein 2 ARRDC2 PP2703 Homo sapiens (Human) TR30806_c1_g1_i1 Q61967 ZFP90_MOUSE 1.00E-34 GO:0003677; GO:0001078; GO:0046872; GO:0043392; GO:0005634; GO:0045893 "DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; metal ion binding; negative regulation of DNA binding; nucleus; positive regulation of transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 90 (Zfp-90) (Zinc finger protein NK10) Zfp90 Nk10 Mus musculus (Mouse) TR30806_c1_g1_i2 Q96N38 ZN714_HUMAN 3.00E-24 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 714 ZNF714 Homo sapiens (Human) TR30807_c0_g1_i3 Q5XIN7 PMGT1_RAT 3.00E-10 GO:0000139; GO:0008375; GO:0016021; GO:0006493 Golgi membrane; acetylglucosaminyltransferase activity; integral to membrane; protein O-linked glycosylation IPR004139; Protein modification; protein glycosylation. "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) (EC 2.4.1.-)" Pomgnt1 Rattus norvegicus (Rat) TR30807_c0_g1_i4 P27115 MGAT1_RABIT 8.00E-71 GO:0005797; GO:0000139; GO:0003827; GO:0016021; GO:0006013; GO:0046872; GO:0016262; GO:0006487 "Golgi medial cisterna; Golgi membrane; alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity; integral to membrane; mannose metabolic process; metal ion binding; protein N-acetylglucosaminyltransferase activity; protein N-linked glycosylation" IPR004139; Protein modification; protein glycosylation. "Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.101) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I) (GNT-I) (GlcNAc-T I)" MGAT1 GNT1 Oryctolagus cuniculus (Rabbit) TR30808_c0_g1_i1 P53692 SMC6_SCHPO 1.00E-30 GO:0005524; GO:0006281; GO:0030915; GO:0000724; GO:0007126; GO:0005634; GO:0048478 Q53EK2; Q4PIR3; Q9Y7U4; Q6BDR8; O94668; O13688; O13710 ATP binding; DNA repair; Smc5-Smc6 complex; double-strand break repair via homologous recombination; meiosis; nucleus; replication fork protection IPR027417; IPR003395; IPR027132; Structural maintenance of chromosomes protein 6 (DNA repair protein rad18) smc6 rad18 SPCC5E4.06 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR30808_c0_g1_i2 Q8IY18 SMC5_HUMAN 1.00E-08 GO:0005524; GO:0016605; GO:0030915; GO:0051301; GO:0090398; GO:0000781; GO:0000724; GO:0007067; GO:0034184; GO:0045842; GO:0000722 Q96SB8 "ATP binding; PML body; Smc5-Smc6 complex; cell division; cellular senescence; chromosome, telomeric region; double-strand break repair via homologous recombination; mitosis; positive regulation of maintenance of mitotic sister chromatid cohesion; positive regulation of mitotic metaphase/anaphase transition; telomere maintenance via recombination" IPR027417; IPR003395; IPR027131; Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) SMC5 KIAA0594 SMC5L1 Homo sapiens (Human) TR30808_c1_g1_i1 Q6P9I7 SMC6_XENLA 3.00E-115 GO:0005524; GO:0016605; GO:0030915; GO:0090398; GO:0000781; GO:0000724; GO:0000722 "ATP binding; PML body; Smc5-Smc6 complex; cellular senescence; chromosome, telomeric region; double-strand break repair via homologous recombination; telomere maintenance via recombination" IPR027417; IPR003395; IPR027132; IPR010935; Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (xSMC6) smc6 smc6l1 Xenopus laevis (African clawed frog) TR30808_c2_g1_i1 Q924W5 SMC6_MOUSE 4.00E-14 GO:0005524; GO:0016605; GO:0030915; GO:0090398; GO:0000781; GO:0000724; GO:0000722 "ATP binding; PML body; Smc5-Smc6 complex; cellular senescence; chromosome, telomeric region; double-strand break repair via homologous recombination; telomere maintenance via recombination" IPR027417; IPR003395; IPR027132; Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (mSMC6) Smc6 Kiaa4103 Smc6l1 Mus musculus (Mouse) TR30809_c4_g1_i1 Q96MM6 HS12B_HUMAN 5.00E-15 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR30810_c1_g1_i2 P79782 TCF15_CHICK 2.00E-30 GO:0003677; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011598; Transcription factor 15 (TCF-15) (Paraxis) (Protein bHLH-EC2) TCF15 BHLHEC2 Gallus gallus (Chicken) TR30811_c0_g1_i1 P92204 NELFE_DROME 2.00E-27 GO:0032021; GO:0005694; GO:0003729; GO:0034244; GO:0007070; GO:0022008; GO:0000166; GO:0045944; GO:0006368; GO:0017053 P02828 NELF complex; chromosome; mRNA binding; negative regulation of transcription elongation from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter during mitosis; neurogenesis; nucleotide binding; positive regulation of transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; transcriptional repressor complex IPR012677; IPR000504; Negative elongation factor E Nelf-E anon-66Da CG5994 Drosophila melanogaster (Fruit fly) TR30813_c4_g5_i1 Q5T848 GP158_HUMAN 3.00E-10 GO:0004930; GO:0016021; GO:0005886; GO:0072659; GO:0008277 G-protein coupled receptor activity; integral to membrane; plasma membrane; protein localization to plasma membrane; regulation of G-protein coupled receptor protein signaling pathway IPR017978; Probable G-protein coupled receptor 158 GPR158 KIAA1136 Homo sapiens (Human) TR30814_c0_g2_i1 Q28HC6 TGT_XENTR 2.00E-143 GO:0046872; GO:0008479; GO:0008616 metal ion binding; queuine tRNA-ribosyltransferase activity; queuosine biosynthetic process IPR004803; IPR002616; tRNA modification; tRNA-queuosine biosynthesis. Queuine tRNA-ribosyltransferase (EC 2.4.2.29) (Guanine insertion enzyme) (tRNA-guanine transglycosylase) qtrt1 TEgg001l19.1 TGas042b06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30814_c0_g2_i2 Q28HC6 TGT_XENTR 0 GO:0046872; GO:0008479; GO:0008616 metal ion binding; queuine tRNA-ribosyltransferase activity; queuosine biosynthetic process IPR004803; IPR002616; tRNA modification; tRNA-queuosine biosynthesis. Queuine tRNA-ribosyltransferase (EC 2.4.2.29) (Guanine insertion enzyme) (tRNA-guanine transglycosylase) qtrt1 TEgg001l19.1 TGas042b06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30814_c0_g2_i3 B7Q5K1 QTRD1_IXOSC 2.00E-21 GO:0046872; GO:0008479; GO:0008616 metal ion binding; queuine tRNA-ribosyltransferase activity; queuosine biosynthetic process IPR002616; tRNA modification; tRNA-queuosine biosynthesis. Queuine tRNA-ribosyltransferase subunit QTRTD1 homolog (EC 2.4.2.29) (Queuine tRNA-ribosyltransferase domain-containing protein 1) ISCW021855 Ixodes scapularis (Black-legged tick) (Deer tick) TR30817_c1_g2_i1 P61407 TDRD6_MOUSE 5.00E-18 GO:0043186; GO:0033391; GO:0005783; GO:0007281; GO:0007275; GO:0007283 P granule; chromatoid body; endoplasmic reticulum; germ cell development; multicellular organismal development; spermatogenesis IPR002999; Tudor domain-containing protein 6 Tdrd6 Mus musculus (Mouse) TR30817_c3_g1_i1 Q9BXT4 TDRD1_HUMAN 6.00E-17 GO:0043046; GO:0033391; GO:0031047; GO:0007281; GO:0007126; GO:0046872; GO:0007275; GO:0071546; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; chromatoid body; gene silencing by RNA; germ cell development; meiosis; metal ion binding; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002999; IPR002893; Tudor domain-containing protein 1 (Cancer/testis antigen 41.1) (CT41.1) TDRD1 Homo sapiens (Human) TR30818_c1_g1_i1 Q6NU40 CTF18_XENLA 2.00E-123 GO:0005524; GO:0003677; GO:0006260; GO:0007049; GO:0017111; GO:0005634 ATP binding; DNA binding; DNA replication; cell cycle; nucleoside-triphosphatase activity; nucleus IPR003593; IPR003959; IPR027417; Chromosome transmission fidelity protein 18 homolog chtf18 ctf18 Xenopus laevis (African clawed frog) TR30819_c7_g1_i1 Q9D3A8 CAPON_MOUSE 1.00E-40 IPR011993; IPR006020; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) Nos1ap Capon Kiaa0464 Mus musculus (Mouse) TR30822_c1_g1_i1 P22031 LEG_ANTCR 1.00E-11 GO:0030246; GO:0005737 carbohydrate binding; cytoplasm IPR000922; D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL) Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR30822_c1_g1_i2 P86179 CSL3_ONCKE 2.00E-11 GO:0030246 carbohydrate binding IPR000922; L-rhamnose-binding lectin CSL3 Oncorhynchus keta (Chum salmon) (Salmo keta) TR30822_c1_g1_i3 P86178 CSL2_ONCKE 6.00E-10 GO:0030246 carbohydrate binding IPR000922; L-rhamnose-binding lectin CSL2 Oncorhynchus keta (Chum salmon) (Salmo keta) TR30824_c0_g1_i3 Q8BMP6 GCP60_MOUSE 1.00E-58 GO:0000139; GO:0000062; GO:0016021; GO:0005739; GO:0006694; GO:0006810 Golgi membrane; fatty-acyl-CoA binding; integral to membrane; mitochondrion; steroid biosynthetic process; transport IPR022408; IPR000582; IPR014352; IPR009038; Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) Acbd3 Gcp60 Pap7 Mus musculus (Mouse) TR30827_c2_g1_i1 Q9MYP6 DHB14_BOVIN 9.00E-89 GO:0005813; GO:0005829; GO:0004303; GO:0006706; GO:0047045 centrosome; cytosol; estradiol 17-beta-dehydrogenase activity; steroid catabolic process; testosterone 17-beta-dehydrogenase (NADP+) activity IPR002198; IPR002347; IPR016040; IPR020904; 17-beta-hydroxysteroid dehydrogenase 14 (17-beta-HSD 14) (EC 1.1.1.-) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) HSD17B14 DHRS10 SDR3 Bos taurus (Bovine) TR30829_c1_g1_i1 Q55GK8 KIL1_DICDI 2.00E-11 GO:0042742; GO:0016021; GO:0006477; GO:0008146 defense response to bacterium; integral to membrane; protein sulfation; sulfotransferase activity IPR027417; IPR000863; Membrane-associated sulfotransferase kil1 (EC 2.8.2.-) kil1 DDB_G0267630 Dictyostelium discoideum (Slime mold) TR30829_c1_g1_i2 Q9QZS6 HS3SB_MOUSE 1.00E-107 GO:0000139; GO:0008467; GO:0033872; GO:0005887; GO:0006477 Golgi membrane; [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity; [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity; integral to plasma membrane; protein sulfation IPR027417; IPR000863; Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (EC 2.8.2.30) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1) (3-OST-3B) (Heparan sulfate 3-O-sulfotransferase 3B1) (m3-OST-3B) Hs3st3b1 3ost3b1 Hs3st3b Mus musculus (Mouse) TR30832_c1_g1_i1 Q92192 ACT_CALFI 6.00E-164 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; Actin (Fragment) Calanus finmarchicus (Calanus tonsus) TR30832_c1_g1_i3 P12716 ACTC_PISOC 0 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin, cytoplasmic" Pisaster ochraceus (Ochre sea star) (Asterias ochracea) TR30833_c1_g3_i1 P60815 FLVC2_RAT 4.00E-129 GO:0020037; GO:0015232; GO:0016021; GO:0005886; GO:0055085 heme binding; heme transporter activity; integral to membrane; plasma membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Feline leukemia virus subgroup C receptor-related protein 2 (Calcium-chelate transporter) (CCT) Flvcr2 Rattus norvegicus (Rat) TR30835_c0_g2_i2 B2RYG6 OTUB1_RAT 3.00E-90 GO:0006281; GO:0019784; GO:0005737; GO:2000780; GO:1901315; GO:0008242; GO:0071108; GO:0006508; GO:0006974; GO:0043130; GO:0004843 DNA repair; NEDD8-specific protease activity; cytoplasm; negative regulation of double-strand break repair; negative regulation of histone H2A K63-linked ubiquitination; omega peptidase activity; protein K48-linked deubiquitination; proteolysis; response to DNA damage stimulus; ubiquitin binding; ubiquitin-specific protease activity IPR003323; IPR019400; IPR016615; Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (Ubiquitin-specific-processing protease OTUB1) Otub1 Rattus norvegicus (Rat) TR30837_c0_g1_i1 Q3ZCB2 PLAC8_BOVIN 3.00E-09 GO:0050873; GO:0003682; GO:0042742; GO:0043066; GO:0040015; GO:0008284; GO:0045944; GO:0009409 brown fat cell differentiation; chromatin binding; defense response to bacterium; negative regulation of apoptotic process; negative regulation of multicellular organism growth; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; response to cold IPR006461; Placenta-specific gene 8 protein PLAC8 Bos taurus (Bovine) TR30838_c2_g1_i3 B3A0P4 USP26_LOTGI 4.00E-19 GO:0005576 extracellular region Uncharacterized shell protein 26 (BMSP-like protein) (Fragment) Lottia gigantea (Giant owl limpet) TR30840_c0_g1_i2 Q8C1B2 PARPT_MOUSE 8.00E-21 GO:0003950; GO:0008209; GO:0008210; GO:0060325; GO:0008585; GO:0030097; GO:0001822; GO:0046872; GO:0044236; GO:0006807; GO:0060021; GO:0048008; GO:0009791; GO:0006471; GO:0048705; GO:0048745; GO:0001570 NAD+ ADP-ribosyltransferase activity; androgen metabolic process; estrogen metabolic process; face morphogenesis; female gonad development; hemopoiesis; kidney development; metal ion binding; multicellular organismal metabolic process; nitrogen compound metabolic process; palate development; platelet-derived growth factor receptor signaling pathway; post-embryonic development; protein ADP-ribosylation; skeletal system morphogenesis; smooth muscle tissue development; vasculogenesis IPR012317; IPR004170; IPR000571; TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) Tiparp Mus musculus (Mouse) TR30843_c2_g2_i2 A4IJ15 K1430_XENTR 2.00E-12 UPF0501 protein KIAA1430 homolog Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30844_c5_g1_i2 O88845 AKA10_MOUSE 3.00E-53 GO:0005739; GO:0005886; GO:0051018; GO:0008104; GO:0038032 mitochondrion; plasma membrane; protein kinase A binding; protein localization; termination of G-protein coupled receptor signaling pathway IPR016137; IPR000342; "A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10)" Akap10 Mus musculus (Mouse) TR30844_c6_g3_i4 Q4V8S3 TM242_DANRE 1.00E-12 GO:0016021 integral to membrane IPR009792; Transmembrane protein 242 tmem242 si:dkey-60a16.5 Danio rerio (Zebrafish) (Brachydanio rerio) TR30846_c6_g1_i2 Q9R088 KITM_MOUSE 3.00E-77 GO:0005524; GO:0009262; GO:0006264; GO:0005743; GO:0016773; GO:0004797 "ATP binding; deoxyribonucleotide metabolic process; mitochondrial DNA replication; mitochondrial inner membrane; phosphotransferase activity, alcohol group as acceptor; thymidine kinase activity" IPR002624; IPR027417; "Thymidine kinase 2, mitochondrial (EC 2.7.1.21) (Mt-TK)" Tk2 Mus musculus (Mouse) TR30847_c0_g2_i2 P02637 SCP_MIZYE 7.00E-68 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Sarcoplasmic calcium-binding protein (SCP) Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) TR30848_c0_g1_i1 Q8VCX6 KPTN_MOUSE 3.00E-68 GO:0030426; GO:0048471; GO:0032420 growth cone; perinuclear region of cytoplasm; stereocilium Kaptin Kptn Mus musculus (Mouse) TR30849_c0_g1_i1 Q8CDF7 EXD1_MOUSE 3.00E-18 GO:0008408; GO:0003676; GO:0090305 3'-5' exonuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis IPR002562; IPR012337; Exonuclease 3'-5' domain-containing protein 1 (Exonuclease 3'-5' domain-like-containing protein 1) Exd1 Exdl1 Mus musculus (Mouse) TR30850_c0_g1_i1 P86855 PWAPL_MYTGA 7.00E-17 GO:0005576; GO:0010466; GO:0030414 extracellular region; negative regulation of peptidase activity; peptidase inhibitor activity IPR008197; Perlwapin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR30851_c0_g1_i1 Q93099 HGD_HUMAN 0 GO:0006559; GO:0034641; GO:0005829; GO:0004411; GO:0046872; GO:0006572 "L-phenylalanine catabolic process; cellular nitrogen compound metabolic process; cytosol; homogentisate 1,2-dioxygenase activity; metal ion binding; tyrosine catabolic process" IPR005708; IPR014710; IPR011051; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. "Homogentisate 1,2-dioxygenase (EC 1.13.11.5) (Homogentisate oxygenase) (Homogentisic acid oxidase) (Homogentisicase)" HGD HGO Homo sapiens (Human) TR30851_c0_g1_i2 A4JBW6 HGD_BURVG 4.00E-161 GO:0006559; GO:0004411; GO:0005506; GO:0006572 "L-phenylalanine catabolic process; homogentisate 1,2-dioxygenase activity; iron ion binding; tyrosine catabolic process" IPR005708; IPR022950; IPR014710; IPR011051; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. "Homogentisate 1,2-dioxygenase (EC 1.13.11.5) (Homogentisate oxygenase) (Homogentisic acid oxidase) (Homogentisicase)" hmgA Bcep1808_0757 Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808)) TR30851_c0_g1_i6 Q9KSB4 Y1345_VIBCH 1.00E-08 GO:0006559; GO:0004411; GO:0046872; GO:0016491; GO:0006570 "L-phenylalanine catabolic process; homogentisate 1,2-dioxygenase activity; metal ion binding; oxidoreductase activity; tyrosine metabolic process" IPR005708; IPR014710; IPR011051; Putative dioxygenase VC_1345 (EC 1.13.-.-) VC_1345 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) TR30851_c0_g2_i1 Q93099 HGD_HUMAN 2.00E-69 GO:0006559; GO:0034641; GO:0005829; GO:0004411; GO:0046872; GO:0006572 "L-phenylalanine catabolic process; cellular nitrogen compound metabolic process; cytosol; homogentisate 1,2-dioxygenase activity; metal ion binding; tyrosine catabolic process" IPR005708; IPR014710; IPR011051; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. "Homogentisate 1,2-dioxygenase (EC 1.13.11.5) (Homogentisate oxygenase) (Homogentisic acid oxidase) (Homogentisicase)" HGD HGO Homo sapiens (Human) TR30855_c2_g1_i1 Q9VAC5 ADA17_DROME 7.00E-102 GO:0016021; GO:0006509; GO:0004222; GO:0008270 integral to membrane; membrane protein ectodomain proteolysis; metalloendopeptidase activity; zinc ion binding IPR001762; IPR024079; IPR001590; IPR002870; ADAM 17-like protease (EC 3.4.24.-) Tace CG7908 Drosophila melanogaster (Fruit fly) TR30855_c2_g1_i2 O77636 ADA17_PIG 1.00E-21 GO:0007219; GO:0016020; GO:0006509; GO:0046872; GO:0004222 Notch signaling pathway; membrane; membrane protein ectodomain proteolysis; metal ion binding; metalloendopeptidase activity IPR024079; IPR001590; Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) (Fragment) ADAM17 TACE Sus scrofa (Pig) TR30858_c0_g1_i1 Q9NR30 DDX21_HUMAN 0 GO:0005524; GO:0004004; GO:0003725; GO:0005730; GO:0043330; GO:0009615 ATP binding; ATP-dependent RNA helicase activity; double-stranded RNA binding; nucleolus; response to exogenous dsRNA; response to virus IPR011545; IPR012562; IPR014001; IPR001650; IPR027417; IPR014014; Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) DDX21 Homo sapiens (Human) TR30858_c0_g1_i2 Q6YS30 RH5_ORYSJ 5.00E-59 GO:0005524; GO:0008026; GO:0003723; GO:0005730; GO:0006364 ATP binding; ATP-dependent helicase activity; RNA binding; nucleolus; rRNA processing IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; DEAD-box ATP-dependent RNA helicase 5 (EC 3.6.4.13) Os07g0301200 LOC_Os07g20580 B1114D08.16-1 Oryza sativa subsp. japonica (Rice) TR30861_c0_g1_i1 Q5M8F9 ALKMO_XENTR 1.00E-07 GO:0005783; GO:0005789; GO:0046485; GO:0006633; GO:0050479; GO:0016021; GO:0005506; GO:0006643 endoplasmic reticulum; endoplasmic reticulum membrane; ether lipid metabolic process; fatty acid biosynthetic process; glyceryl-ether monooxygenase activity; integral to membrane; iron ion binding; membrane lipid metabolic process IPR006694; Alkylglycerol monooxygenase (EC 1.14.16.5) (Transmembrane protein 195) agmo tmem195 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30861_c1_g1_i2 Q8BS35 ALKMO_MOUSE 5.00E-78 GO:0005783; GO:0005789; GO:0046485; GO:0006633; GO:0050479; GO:0016021; GO:0005506; GO:0006643 endoplasmic reticulum; endoplasmic reticulum membrane; ether lipid metabolic process; fatty acid biosynthetic process; glyceryl-ether monooxygenase activity; integral to membrane; iron ion binding; membrane lipid metabolic process IPR006694; Alkylglycerol monooxygenase (EC 1.14.16.5) (Transmembrane protein 195) Agmo Tmem195 Mus musculus (Mouse) TR30862_c3_g1_i1 B1H369 HDAC8_XENTR 7.00E-111 GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0005737; GO:0070932; GO:0070933; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); cytoplasm; histone H3 deacetylation; histone H4 deacetylation; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000286; IPR003084; IPR023801; Histone deacetylase 8 (HD8) (EC 3.5.1.98) hdac8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30862_c3_g1_i2 Q9LXN8 HDA17_ARATH 3.00E-14 GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0070932; GO:0070933; GO:0005634; GO:0006355; GO:0006351 "NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone H3 deacetylation; histone H4 deacetylation; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000286; IPR023801; Histone deacetylase 17 (EC 3.5.1.98) HDA17 At3g44490 F14L2.40 Arabidopsis thaliana (Mouse-ear cress) TR30865_c2_g1_i1 Q5F464 LPP_CHICK 1.00E-98 GO:0007155; GO:0005737; GO:0005925; GO:0005634; GO:0008270 cell adhesion; cytoplasm; focal adhesion; nucleus; zinc ion binding IPR001781; Lipoma-preferred partner homolog LPP RCJMB04_2l20 Gallus gallus (Chicken) TR30866_c0_g1_i1 Q8TGM7 ART2_YEAST 4.00E-30 Putative uncharacterized protein ART2 (Antisense to ribosomal RNA transcript protein 2) ART2 YLR154W-A YLR154W-C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR30867_c2_g1_i1 P47863 AQP4_RAT 8.00E-57 GO:0030315; GO:0015670; GO:0071392; GO:0071346; GO:0005737; GO:0009897; GO:0007565; GO:0042538; GO:0005887; GO:0050891; GO:0015288; GO:0043234; GO:0051260; GO:0051384; GO:0009314; GO:0015250 T-tubule; carbon dioxide transport; cellular response to estradiol stimulus; cellular response to interferon-gamma; cytoplasm; external side of plasma membrane; female pregnancy; hyperosmotic salinity response; integral to plasma membrane; multicellular organismal water homeostasis; porin activity; protein complex; protein homooligomerization; response to glucocorticoid stimulus; response to radiation; water channel activity IPR023271; IPR000425; IPR022357; Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4) Aqp4 Rattus norvegicus (Rat) TR3087_c0_g1_i1 Q8Q0U0 Y045_METMA 9.00E-12 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR30870_c1_g2_i1 Q969F8 KISSR_HUMAN 6.00E-47 GO:0000186; GO:0050482; GO:0007610; GO:0019722; GO:0009986; GO:0016021; GO:0008285; GO:0042923; GO:0008188; GO:0005886; GO:0046887; GO:0051496; GO:0050806 P67775 activation of MAPKK activity; arachidonic acid secretion; behavior; calcium-mediated signaling; cell surface; integral to membrane; negative regulation of cell proliferation; neuropeptide binding; neuropeptide receptor activity; plasma membrane; positive regulation of hormone secretion; positive regulation of stress fiber assembly; positive regulation of synaptic transmission IPR000276; IPR017452; IPR008103; KiSS-1 receptor (KiSS-1R) (G-protein coupled receptor 54) (G-protein coupled receptor OT7T175) (hOT7T175) (Hypogonadotropin-1) (Kisspeptins receptor) (Metastin receptor) KISS1R AXOR12 GPR54 Homo sapiens (Human) TR30873_c0_g1_i1 Q8R0F5 RBMX2_MOUSE 4.00E-68 GO:0003723; GO:0000166 RNA binding; nucleotide binding IPR012677; IPR000504; "RNA-binding motif protein, X-linked 2" Rbmx2 Mus musculus (Mouse) TR30874_c2_g1_i1 Q66JN8 RSG1_DANRE 1.00E-64 GO:0005525; GO:0034613; GO:0005929; GO:0042384; GO:0005737; GO:0006887; GO:0005932; GO:0015031; GO:0017157; GO:0031338; GO:0007264 GTP binding; cellular protein localization; cilium; cilium assembly; cytoplasm; exocytosis; microtubule basal body; protein transport; regulation of exocytosis; regulation of vesicle fusion; small GTPase mediated signal transduction IPR013684; IPR027417; IPR001806; REM2- and Rab-like small GTPase 1 rsg1 zgc:101035 Danio rerio (Zebrafish) (Brachydanio rerio) TR30874_c2_g1_i2 Q9BU20 RSG1_HUMAN 9.00E-76 GO:0005525; GO:0034613; GO:0005929; GO:0042384; GO:0005737; GO:0006887; GO:0005932; GO:0015031; GO:0017157; GO:0031338; GO:0007264 GTP binding; cellular protein localization; cilium; cilium assembly; cytoplasm; exocytosis; microtubule basal body; protein transport; regulation of exocytosis; regulation of vesicle fusion; small GTPase mediated signal transduction IPR013684; IPR027417; IPR001806; REM2- and Rab-like small GTPase 1 RSG1 C1orf89 Homo sapiens (Human) TR30879_c0_g1_i1 A2VDB3 RBM42_XENLA 2.00E-54 GO:0003723; GO:0005737; GO:0000166; GO:0005634 RNA binding; cytoplasm; nucleotide binding; nucleus IPR012677; IPR000504; RNA-binding protein 42 (RNA-binding motif protein 42) rbm42 Xenopus laevis (African clawed frog) TR30880_c0_g1_i1 A5PK45 GT251_BOVIN 0 GO:0005788; GO:0009103; GO:0050211 endoplasmic reticulum lumen; lipopolysaccharide biosynthetic process; procollagen galactosyltransferase activity IPR002654; Procollagen galactosyltransferase 1 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 1) (Glycosyltransferase 25 family member 1) (Hydroxylysine galactosyltransferase 1) COLGALT1 GLT25D1 Bos taurus (Bovine) TR30881_c11_g1_i1 Q8IXQ6 PARP9_HUMAN 5.00E-08 GO:0003950; GO:0016477; GO:0005737; GO:0005829; GO:0006302; GO:0005634; GO:0060330 NAD+ ADP-ribosyltransferase activity; cell migration; cytoplasm; cytosol; double-strand break repair; nucleus; regulation of response to interferon-gamma IPR002589; IPR012317; Poly [ADP-ribose] polymerase 9 (PARP-9) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 9) (ARTD9) (B aggressive lymphoma protein) PARP9 BAL BAL1 Homo sapiens (Human) TR30881_c8_g1_i1 Q8BFW4 TRI65_MOUSE 5.00E-06 GO:0008270 zinc ion binding IPR001870; IPR003879; IPR008985; IPR006574; IPR003877; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 65 Trim65 Mus musculus (Mouse) TR30881_c8_g2_i2 Q8TDB6 DTX3L_HUMAN 8.00E-40 GO:0005737; GO:0006302; GO:0042393; GO:0010390; GO:0005634; GO:0004842; GO:0008270 cytoplasm; double-strand break repair; histone binding; histone monoubiquitination; nucleus; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) TR30883_c0_g1_i1 Q8IV20 LACC1_HUMAN 8.00E-51 IPR003730; IPR011324; Laccase domain-containing protein 1 LACC1 C13orf31 Homo sapiens (Human) TR30884_c4_g1_i1 Q9QWW1 HOME2_MOUSE 5.00E-86 GO:0007216; GO:0030160; GO:0003779; GO:0045177; GO:0048148; GO:0035584; GO:0030054; GO:0048875; GO:0005737; GO:0030425; GO:0043025; GO:0014069; GO:0045211; GO:0008277 G-protein coupled glutamate receptor signaling pathway; GKAP/Homer scaffold activity; actin binding; apical part of cell; behavioral response to cocaine; calcium-mediated signaling using intracellular calcium source; cell junction; chemical homeostasis within a tissue; cytoplasm; dendrite; neuronal cell body; postsynaptic density; postsynaptic membrane; regulation of G-protein coupled receptor protein signaling pathway IPR011993; IPR000697; Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up-regulated during seizure and LTP 2) (Vesl-2) Homer2 Vesl2 Mus musculus (Mouse) TR30884_c4_g1_i2 Q5TJ65 VASP_DICDI 1.00E-09 GO:0051017; GO:0030041; GO:0045010; GO:0005938; GO:0031252; GO:0031589; GO:0006935; GO:0005856; GO:0005829; GO:0030175; GO:0046847; GO:0050922; GO:0051289 Q54N00 actin filament bundle assembly; actin filament polymerization; actin nucleation; cell cortex; cell leading edge; cell-substrate adhesion; chemotaxis; cytoskeleton; cytosol; filopodium; filopodium assembly; negative regulation of chemotaxis; protein homotetramerization IPR011993; IPR017354; IPR014885; IPR000697; IPR003124; Protein VASP homolog (DdVASP) vasp DDB_G0289541 Dictyostelium discoideum (Slime mold) TR30886_c1_g1_i1 Q14872 MTF1_HUMAN 2.00E-96 GO:0000979; GO:0001047; GO:0046872; GO:0005634; GO:0045944; GO:0006357; GO:0046686; GO:0010038; GO:0006979; GO:0003700; GO:0003713; GO:0006351 Q9BXS5 "RNA polymerase II core promoter sequence-specific DNA binding; core promoter binding; metal ion binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; response to cadmium ion; response to metal ion; response to oxidative stress; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Metal regulatory transcription factor 1 (MRE-binding transcription factor) (Transcription factor MTF-1) MTF1 Homo sapiens (Human) TR30887_c0_g1_i2 Q3SYK4 VRTN_MOUSE 1.00E-13 Vertnin Vrtn Mus musculus (Mouse) TR30890_c1_g1_i1 Q3UW12 CNGA4_MOUSE 3.00E-27 GO:0030552; GO:0030553; GO:0005887; GO:0005222; GO:0005223; GO:0007603; GO:0042391; GO:0007608; GO:0005249 "cAMP binding; cGMP binding; integral to plasma membrane; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; phototransduction, visible light; regulation of membrane potential; sensory perception of smell; voltage-gated potassium channel activity" IPR018490; IPR018488; IPR000595; IPR005821; IPR014710; Cyclic nucleotide-gated cation channel alpha-4 (Cyclic nucleotide-gated channel alpha-4) (CNG channel alpha-4) (CNG-4) (CNG4) Cnga4 Mus musculus (Mouse) TR30890_c1_g1_i2 Q03611 CNG_CAEEL 2.00E-31 GO:0009454; GO:0030553; GO:0030425; GO:0005887; GO:0005222; GO:0005223; GO:0048812; GO:0031513; GO:0042048; GO:0007603; GO:0045944; GO:0030516; GO:0042391; GO:0055093; GO:0040040; GO:0043052; GO:0005249 "aerotaxis; cGMP binding; dendrite; integral to plasma membrane; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; neuron projection morphogenesis; nonmotile primary cilium; olfactory behavior; phototransduction, visible light; positive regulation of transcription from RNA polymerase II promoter; regulation of axon extension; regulation of membrane potential; response to hyperoxia; thermosensory behavior; thermotaxis; voltage-gated potassium channel activity" IPR018490; IPR018488; IPR000595; IPR005821; IPR003938; IPR014710; Cyclic nucleotide-gated cation channel (Abnormal chemotaxis protein 4) tax-4 ZC84.2 Caenorhabditis elegans TR30890_c1_g2_i1 Q38898 AKT2_ARATH 2.00E-07 GO:0005789; GO:0016021; GO:0009506; GO:0042391; GO:0009737; GO:0005249 Itself; Q38998; Q39128; Q38849; P49598 endoplasmic reticulum membrane; integral to membrane; plasmodesma; regulation of membrane potential; response to abscisic acid stimulus; voltage-gated potassium channel activity IPR002110; IPR020683; IPR018490; IPR000595; IPR005821; IPR021789; IPR003938; IPR014710; Potassium channel AKT2/3 AKT2 AKT3 At4g22200 T10I14.30 Arabidopsis thaliana (Mouse-ear cress) TR30890_c1_g3_i1 Q90980 CNG3_CHICK 7.00E-41 GO:0030552; GO:0030553; GO:0005887; GO:0005222; GO:0005223; GO:0042622; GO:0007603; GO:0042391; GO:0007601; GO:0005249 "cAMP binding; cGMP binding; integral to plasma membrane; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; photoreceptor outer segment membrane; phototransduction, visible light; regulation of membrane potential; visual perception; voltage-gated potassium channel activity" IPR018490; IPR018488; IPR000595; IPR005821; IPR014710; Cyclic nucleotide-gated channel rod photoreceptor subunit alpha (CNG channel 3) (CNG-3) (CNG3) Gallus gallus (Chicken) TR30892_c0_g2_i1 Q69ZJ7 RIC1_MOUSE 2.00E-54 GO:0016021 integral to membrane IPR011044; IPR009771; IPR015943; Protein RIC1 homolog Kiaa1432 Mus musculus (Mouse) TR30892_c2_g1_i1 Q09417 RIC1_CAEEL 6.00E-44 GO:0016021 integral to membrane IPR009771; IPR015943; IPR017986; Protein RIC1 homolog R06F6.8 Caenorhabditis elegans TR30894_c0_g2_i1 Q16FT5 COQ4_AEDAE 4.00E-88 GO:0031314; GO:0006744 extrinsic to mitochondrial inner membrane; ubiquinone biosynthetic process IPR007715; IPR027540; Cofactor biosynthesis; ubiquinone biosynthesis. "Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial (Coenzyme Q biosynthesis protein 4 homolog)" AAEL014646 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR30895_c0_g1_i1 Q9Z2Q5 RM40_MOUSE 5.00E-18 GO:0005761 mitochondrial ribosome IPR019192; "39S ribosomal protein L40, mitochondrial (L40mt) (MRP-L40) (Nuclear localization signal-containing protein deleted in velocardiofacial syndrome homolog)" Mrpl40 Nlvcf Mus musculus (Mouse) TR30895_c0_g1_i3 Q9Z2Q5 RM40_MOUSE 1.00E-14 GO:0005761 mitochondrial ribosome IPR019192; "39S ribosomal protein L40, mitochondrial (L40mt) (MRP-L40) (Nuclear localization signal-containing protein deleted in velocardiofacial syndrome homolog)" Mrpl40 Nlvcf Mus musculus (Mouse) TR30896_c5_g1_i1 Q92636 FAN_HUMAN 1.00E-41 GO:0006672; GO:0005737; GO:0005057 P60709; O95166; Q9H0R8; P50552 ceramide metabolic process; cytoplasm; receptor signaling protein activity IPR000409; IPR004182; IPR023362; IPR015943; IPR001680; IPR017986; Protein FAN (Factor associated with neutral sphingomyelinase activation) (Factor associated with N-SMase activation) NSMAF FAN Homo sapiens (Human) TR30896_c5_g1_i2 Q6ZS30 NBEL1_HUMAN 0 IPR016024; IPR000409; IPR008985; IPR026916; IPR023362; IPR015943; IPR001680; IPR017986; Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) NBEAL1 ALS2CR16 ALS2CR17 Homo sapiens (Human) TR30898_c2_g1_i1 Q8CI17 MB213_MOUSE 7.00E-06 IPR024810; IPR024802; Protein mab-21-like 3 Mab21L3 Mus musculus (Mouse) TR3090_c0_g1_i1 Q6PBM1 GLRX5_DANRE 3.00E-53 GO:0051537; GO:0045454; GO:0009055; GO:0030097; GO:0016226; GO:0046872; GO:0005739; GO:0015035 "2 iron, 2 sulfur cluster binding; cell redox homeostasis; electron carrier activity; hemopoiesis; iron-sulfur cluster assembly; metal ion binding; mitochondrion; protein disulfide oxidoreductase activity" IPR002109; IPR004480; IPR012336; "Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5)" glrx5 grx5 shiraz si:ch211-121d13.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR30901_c0_g1_i3 P86734 EPDR1_HALAI 2.00E-08 GO:0005509; GO:0007160; GO:0005576 calcium ion binding; cell-matrix adhesion; extracellular region IPR001299; Ependymin-related protein 1 Sometsuke Haliotis asinina (Donkey's ear abalone) (Ass's ear abalone) TR30901_c0_g1_i6 P86734 EPDR1_HALAI 2.00E-08 GO:0005509; GO:0007160; GO:0005576 calcium ion binding; cell-matrix adhesion; extracellular region IPR001299; Ependymin-related protein 1 Sometsuke Haliotis asinina (Donkey's ear abalone) (Ass's ear abalone) TR30902_c2_g1_i1 A6N7Y9 PIWL1_CHICK 3.00E-39 GO:0003677; GO:0043186; GO:0033391; GO:0031047; GO:0003729; GO:0005845; GO:0007126; GO:0007275; GO:0034584; GO:0034587; GO:0005844; GO:0006417; GO:0003727; GO:0007286 DNA binding; P granule; chromatoid body; gene silencing by RNA; mRNA binding; mRNA cap binding complex; meiosis; multicellular organismal development; piRNA binding; piRNA metabolic process; polysome; regulation of translation; single-stranded RNA binding; spermatid development IPR017956; IPR003100; IPR003165; IPR012337; Piwi-like protein 1 PIWIL1 Gallus gallus (Chicken) TR30903_c5_g3_i2 Q8N884 M21D1_HUMAN 5.00E-11 GO:0005524; GO:0003677; GO:0005525; GO:0002218; GO:0071360; GO:0009190; GO:0061501; GO:0005829; GO:0051607; GO:0045087; GO:0046872; GO:0002230; GO:0032481 ATP binding; DNA binding; GTP binding; activation of innate immune response; cellular response to exogenous dsRNA; cyclic nucleotide biosynthetic process; cyclic-GMP-AMP synthase activity; cytosol; defense response to virus; innate immune response; metal ion binding; positive regulation of defense response to virus by host; positive regulation of type I interferon production IPR024810; IPR024805; Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (Mab-21 domain-containing protein 1) MB21D1 C6orf150 Homo sapiens (Human) TR30904_c0_g1_i3 Q9V0D5 MDH_PYRAB 2.00E-62 GO:0030060; GO:0005737; GO:0006099 L-malate dehydrogenase activity; cytoplasm; tricarboxylic acid cycle IPR003767; Malate dehydrogenase (EC 1.1.1.37) mdh PYRAB08550 PAB1791 Pyrococcus abyssi (strain GE5 / Orsay) TR30906_c1_g1_i1 P39524 ATC3_YEAST 6.00E-43 GO:0005524; GO:0005794; GO:0019829; GO:0006897; GO:0016021; GO:0006886; GO:0000287; GO:0045332; GO:0004012; GO:0006892; GO:0000028; GO:0005802 ATP binding; Golgi apparatus; cation-transporting ATPase activity; endocytosis; integral to membrane; intracellular protein transport; magnesium ion binding; phospholipid translocation; phospholipid-translocating ATPase activity; post-Golgi vesicle-mediated transport; ribosomal small subunit assembly; trans-Golgi network IPR023299; IPR018303; IPR006539; IPR008250; IPR001757; IPR023214; Probable phospholipid-transporting ATPase DRS2 (EC 3.6.3.1) DRS2 YAL026C FUN38 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR30906_c3_g1_i1 O54827 AT10A_MOUSE 3.00E-35 GO:0005524; GO:0019829; GO:0005789; GO:0016021; GO:0000287; GO:0004012; GO:0005886 ATP binding; cation-transporting ATPase activity; endoplasmic reticulum membrane; integral to membrane; magnesium ion binding; phospholipid-translocating ATPase activity; plasma membrane IPR023299; IPR018303; IPR006539; IPR008250; IPR001757; IPR023214; Probable phospholipid-transporting ATPase VA (EC 3.6.3.1) (ATPase class V type 10A) (P-locus fat-associated ATPase) Atp10a Atpc5 Pfatp Mus musculus (Mouse) TR30906_c5_g1_i1 P98198 AT8B2_HUMAN 2.00E-86 GO:0005524; GO:0019829; GO:0016021; GO:0034220; GO:0000287; GO:0004012; GO:0005886 ATP binding; cation-transporting ATPase activity; integral to membrane; ion transmembrane transport; magnesium ion binding; phospholipid-translocating ATPase activity; plasma membrane IPR023299; IPR018303; IPR006539; IPR008250; IPR001757; IPR023214; Probable phospholipid-transporting ATPase ID (EC 3.6.3.1) (ATPase class I type 8B member 2) ATP8B2 ATPID KIAA1137 Homo sapiens (Human) TR30908_c0_g1_i2 P14842 5HT2A_RAT 4.00E-47 GO:0071886; GO:0070371; GO:0001965; GO:0007568; GO:0014824; GO:0030424; GO:0048148; GO:0005901; GO:0070852; GO:0008219; GO:0016023; GO:0005829; GO:0043198; GO:0050966; GO:0050965; GO:0008144; GO:0007204; GO:0005887; GO:0007613; GO:0043267; GO:0051967; GO:0043025; GO:0014065; GO:0006661; GO:0004435; GO:0007208; GO:0005886; GO:0043406; GO:0008284; GO:0045907; GO:0050795; GO:0014059; GO:0046883; GO:0051209; GO:0042493; GO:0051378; GO:0004993; GO:0030431; GO:0001659; GO:0014832 P31421 "1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding; ERK1 and ERK2 cascade; G-protein alpha-subunit binding; aging; artery smooth muscle contraction; axon; behavioral response to cocaine; caveola; cell body fiber; cell death; cytoplasmic membrane-bounded vesicle; cytosol; dendritic shaft; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; drug binding; elevation of cytosolic calcium ion concentration; integral to plasma membrane; memory; negative regulation of potassium ion transport; negative regulation of synaptic transmission, glutamatergic; neuronal cell body; phosphatidylinositol 3-kinase cascade; phosphatidylinositol biosynthetic process; phosphatidylinositol phospholipase C activity; phospholipase C-activating serotonin receptor signaling pathway; plasma membrane; positive regulation of MAP kinase activity; positive regulation of cell proliferation; positive regulation of vasoconstriction; regulation of behavior; regulation of dopamine secretion; regulation of hormone secretion; release of sequestered calcium ion into cytosol; response to drug; serotonin binding; serotonin receptor activity; sleep; temperature homeostasis; urinary bladder smooth muscle contraction" IPR000455; IPR002231; IPR000276; IPR017452; 5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A) Htr2a Htr2 Rattus norvegicus (Rat) TR30908_c0_g3_i1 P34973 DRD2B_XENLA 1.00E-18 GO:0007195; GO:0004935; GO:0071875; GO:0004952; GO:0005887 adenylate cyclase-inhibiting dopamine receptor signaling pathway; adrenergic receptor activity; adrenergic receptor signaling pathway; dopamine neurotransmitter receptor activity; integral to plasma membrane IPR002233; IPR001922; IPR000929; IPR000276; IPR017452; D(2) dopamine receptor B (D2R-B) (D2R 2) (Fragment) drd2-b Xenopus laevis (African clawed frog) TR30912_c0_g1_i1 O95257 GA45G_HUMAN 2.00E-17 GO:0006281; GO:0000186; GO:0000185; GO:0006915; GO:0030154; GO:0007275; GO:0006469; GO:0005634; GO:0051726 Q8TAE8; Q92993; Q9P2H0; Q9Y3C7; Q9BVJ6 DNA repair; activation of MAPKK activity; activation of MAPKKK activity; apoptotic process; cell differentiation; multicellular organismal development; negative regulation of protein kinase activity; nucleus; regulation of cell cycle IPR024824; IPR004038; Growth arrest and DNA damage-inducible protein GADD45 gamma (Cytokine-responsive protein CR6) (DNA damage-inducible transcript 2 protein) (DDIT-2) GADD45G CR6 DDIT2 Homo sapiens (Human) TR30914_c7_g1_i1 Q8BG39 SV2B_MOUSE 3.00E-41 GO:0001669; GO:0030054; GO:0016021; GO:0006836; GO:0007268; GO:0008021; GO:0030672; GO:0022857 acrosomal vesicle; cell junction; integral to membrane; neurotransmitter transport; synaptic transmission; synaptic vesicle; synaptic vesicle membrane; transmembrane transporter activity IPR001646; IPR011701; IPR020846; IPR016196; IPR005828; IPR005829; IPR022308; Synaptic vesicle glycoprotein 2B (Synaptic vesicle protein 2B) Sv2b Kiaa0735 Mus musculus (Mouse) TR30914_c7_g1_i2 Q9Z2I6 SV2C_RAT 2.00E-41 GO:0030054; GO:0016021; GO:0006836; GO:0008021; GO:0030672; GO:0022857 cell junction; integral to membrane; neurotransmitter transport; synaptic vesicle; synaptic vesicle membrane; transmembrane transporter activity IPR001646; IPR011701; IPR020846; IPR016196; IPR005828; IPR005829; IPR022308; Synaptic vesicle glycoprotein 2C (Synaptic vesicle protein 2C) Sv2c Rattus norvegicus (Rat) TR30914_c7_g2_i1 Q940M4 OCT7_ARATH 4.00E-21 GO:0005524; GO:0090417; GO:0016021; GO:0090416; GO:0005886; GO:0022857 ATP binding; N-methylnicotinate transporter activity; integral to membrane; nicotinate transporter activity; plasma membrane; transmembrane transporter activity IPR020846; IPR016196; IPR005828; IPR005829; Organic cation/carnitine transporter 7 (AtOCT7) OCT7 7-Oct At3g13050 MGH6.16 Arabidopsis thaliana (Mouse-ear cress) TR30914_c9_g1_i1 Q8IVG5 SAM9L_HUMAN 2.00E-06 IPR001660; IPR013761; Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) SAMD9L C7orf6 DRIF2 KIAA2005 UEF Homo sapiens (Human) TR30919_c0_g1_i1 Q8CHP8 PGP_MOUSE 9.00E-56 GO:0005975; GO:0016311; GO:0008967 carbohydrate metabolic process; dephosphorylation; phosphoglycolate phosphatase activity IPR023214; IPR006357; IPR023215; IPR006349; Phosphoglycolate phosphatase (PGP) (PGPase) (EC 3.1.3.18) Pgp Mus musculus (Mouse) TR30923_c0_g1_i1 Q8CFN2 CDC42_RAT 6.00E-45 GO:0005525; GO:0003924; GO:0000139; GO:0007030; GO:0090135; GO:0051017; GO:0034332; GO:0045177; GO:0060070; GO:0003161; GO:0034613; GO:0005829; GO:0090136; GO:0060684; GO:0051683; GO:0030010; GO:0035088; GO:0030175; GO:0046847; GO:0031069; GO:0060789; GO:0060047; GO:0031424; GO:0003334; GO:0005815; GO:0030496; GO:0072686; GO:0035264; GO:0010629; GO:0031333; GO:0048664; GO:0043005; GO:0043025; GO:0007097; GO:0072384; GO:0005886; GO:0045740; GO:0046330; GO:0032467; GO:0010628; GO:0071338; GO:0090316; GO:0048554; GO:0043525; GO:0033138; GO:0043552; GO:0031274; GO:1900026; GO:0051835; GO:0051988; GO:0017157; GO:0051489; GO:0007088; GO:0042176; GO:0043497; GO:0045859; GO:0031647; GO:0009749; GO:0030141; GO:0007264; GO:0051233; GO:0002040; GO:0060661 Q9UQB8 GTP binding; GTPase activity; Golgi membrane; Golgi organization; actin filament branching; actin filament bundle assembly; adherens junction organization; apical part of cell; canonical Wnt receptor signaling pathway; cardiac conduction system development; cellular protein localization; cytosol; epithelial cell-cell adhesion; epithelial-mesenchymal cell signaling; establishment of Golgi localization; establishment of cell polarity; establishment or maintenance of apical/basal cell polarity; filopodium; filopodium assembly; hair follicle morphogenesis; hair follicle placode formation; heart contraction; keratinization; keratinocyte development; microtubule organizing center; midbody; mitotic spindle; multicellular organism growth; negative regulation of gene expression; negative regulation of protein complex assembly; neuron fate determination; neuron projection; neuronal cell body; nuclear migration; organelle transport along microtubule; plasma membrane; positive regulation of DNA replication; positive regulation of JNK cascade; positive regulation of cytokinesis; positive regulation of gene expression; positive regulation of hair follicle cell proliferation; positive regulation of intracellular protein transport; positive regulation of metalloenzyme activity; positive regulation of neuron apoptotic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of pseudopodium assembly; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of synapse structural plasticity; regulation of attachment of spindle microtubules to kinetochore; regulation of exocytosis; regulation of filopodium assembly; regulation of mitosis; regulation of protein catabolic process; regulation of protein heterodimerization activity; regulation of protein kinase activity; regulation of protein stability; response to glucose stimulus; secretory granule; small GTPase mediated signal transduction; spindle midzone; sprouting angiogenesis; submandibular salivary gland formation IPR027417; IPR005225; IPR001806; IPR003578; Cell division control protein 42 homolog Cdc42 Rattus norvegicus (Rat) TR30923_c0_g1_i2 Q9GPQ9 RACJ_DICDI 6.00E-10 GO:0005525; GO:0005622; GO:0005886; GO:0019953; GO:0007264 GTP binding; intracellular; plasma membrane; sexual reproduction; small GTPase mediated signal transduction IPR027417; IPR001806; IPR003578; Rho-related protein racJ racJ DDB_G0292560 Dictyostelium discoideum (Slime mold) TR30923_c0_g1_i3 P53879 RHO5_YEAST 2.00E-12 GO:0005525; GO:0003924; GO:0007266; GO:0012505; GO:0000329; GO:0005886 GTP binding; GTPase activity; Rho protein signal transduction; endomembrane system; fungal-type vacuole membrane; plasma membrane IPR027417; IPR005225; IPR001806; IPR003578; GTP-binding protein RHO5 RHO5 YNL180C N1644 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR30925_c0_g1_i3 Q9I8U0 COX41_THUOB 3.00E-21 GO:0004129; GO:0005743 cytochrome-c oxidase activity; mitochondrial inner membrane IPR013288; IPR004203; "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (EC 1.9.3.1) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1)" Thunnus obesus (Bigeye tuna) TR30926_c1_g1_i1 Q5GH61 XK_RAT 5.00E-13 GO:0006865; GO:0016021 amino acid transport; integral to membrane IPR018629; Membrane transport protein XK (XK homolog) (XK-related protein 1) Xk Xkh Xkr1 Xrg1 Rattus norvegicus (Rat) TR30926_c2_g2_i1 Q5GH73 XKR6_HUMAN 3.00E-45 GO:0016021 integral to membrane IPR018629; XK-related protein 6 XKR6 C8orf21 C8orf5 C8orf7 XRG6 Homo sapiens (Human) TR30928_c1_g1_i1 Q08AY6 SET8A_XENLA 1.00E-67 GO:0051301; GO:0005694; GO:0018024; GO:0007067; GO:0005634; GO:0006355; GO:0006351 "cell division; chromosome; histone-lysine N-methyltransferase activity; mitosis; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR016858; IPR001214; N-lysine methyltransferase SETD8-A (EC 2.1.1.-) (Histone-lysine N-methyltransferase SETD8-A) (EC 2.1.1.43) (SET domain-containing protein 8-A) setd8-a Xenopus laevis (African clawed frog) TR30932_c3_g2_i1 G5E8K5 ANK3_MOUSE 4.00E-33 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR30932_c3_g2_i2 Q1RMI3 GABP1_BOVIN 5.00E-16 GO:0005634; GO:0045944; GO:0044212; GO:0006351 "nucleus; positive regulation of transcription from RNA polymerase II promoter; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR002110; IPR020683; GA-binding protein subunit beta-1 (GABP subunit beta-1) (GABPB-1) (GABP subunit beta-2) (GABPB-2) GABPB1 GABPB2 Bos taurus (Bovine) TR30935_c1_g1_i1 P25325 THTM_HUMAN 3.00E-104 GO:0016784; GO:0030054; GO:0009440; GO:0070814; GO:0005739; GO:0043005; GO:0009636; GO:0045202; GO:0004792 3-mercaptopyruvate sulfurtransferase activity; cell junction; cyanate catabolic process; hydrogen sulfide biosynthetic process; mitochondrion; neuron projection; response to toxic substance; synapse; thiosulfate sulfurtransferase activity IPR001763; IPR001307; 3-mercaptopyruvate sulfurtransferase (MST) (EC 2.8.1.2) MPST TST2 Homo sapiens (Human) TR30937_c1_g1_i1 O08746 MATN2_MOUSE 9.00E-13 GO:0007411; GO:0005604; GO:0005509; GO:0031104; GO:0008347; GO:0001764; GO:0048678 axon guidance; basement membrane; calcium ion binding; dendrite regeneration; glial cell migration; neuron migration; response to axon injury IPR000742; IPR001881; IPR013032; IPR000152; IPR009030; IPR019466; IPR002035; Matrilin-2 Matn2 Mus musculus (Mouse) TR30937_c1_g2_i2 C7G0B5 PIF_PINFU 3.00E-14 GO:0008061; GO:0006030; GO:0005578 chitin binding; chitin metabolic process; proteinaceous extracellular matrix IPR002557; IPR002035; Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] Pinctada fucata (Pearl oyster) TR30939_c1_g1_i2 Q4UMH6 Y381_RICFE 7.00E-24 GO:0015969 guanosine tetraphosphate metabolic process IPR002110; IPR020683; IPR007685; Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR30942_c0_g1_i1 Q9D8W5 PSD12_MOUSE 0 GO:0022624 proteasome accessory complex IPR000717; IPR011991; 26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55) Psmd12 Mus musculus (Mouse) TR30948_c0_g1_i2 Q28DB1 MZT2B_XENTR 1.00E-16 GO:0005813; GO:0008274; GO:0005819 centrosome; gamma-tubulin ring complex; spindle IPR024332; Mitotic-spindle organizing protein 2B (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B) mzt2b fam128 mozart2 TEgg010b01.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30948_c0_g1_i6 Q28DB1 MZT2B_XENTR 1.00E-16 GO:0005813; GO:0008274; GO:0005819 centrosome; gamma-tubulin ring complex; spindle IPR024332; Mitotic-spindle organizing protein 2B (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B) mzt2b fam128 mozart2 TEgg010b01.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR30949_c2_g1_i1 Q5SQM0 EMAL6_MOUSE 9.00E-93 GO:0005737; GO:0005874 cytoplasm; microtubule IPR005108; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like) Eml6 Eml5l Mus musculus (Mouse) TR30949_c3_g1_i1 Q6P6T4 EMAL2_RAT 2.00E-22 GO:0003824; GO:0005737; GO:0008152; GO:0005874; GO:0008022; GO:0005102 catalytic activity; cytoplasm; metabolic process; microtubule; protein C-terminus binding; receptor binding IPR005108; IPR011047; IPR011041; IPR015943; IPR001680; IPR017986; Echinoderm microtubule-associated protein-like 2 (EMAP-2) Eml2 Emap2 Rattus norvegicus (Rat) TR30949_c3_g1_i2 O00423 EMAL1_HUMAN 6.00E-23 GO:0005509; GO:0005737; GO:0005874; GO:0005875 Q9H9L3 calcium ion binding; cytoplasm; microtubule; microtubule associated complex IPR005108; IPR011047; IPR015943; IPR001680; IPR017986; Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1) EML1 EMAP1 EMAPL EMAPL1 Homo sapiens (Human) TR30950_c3_g3_i1 O43615 TIM44_HUMAN 5.00E-46 GO:0005524; GO:0015450; GO:0044267; GO:0005743; GO:0005759; GO:0006626 P10398 ATP binding; P-P-bond-hydrolysis-driven protein transmembrane transporter activity; cellular protein metabolic process; mitochondrial inner membrane; mitochondrial matrix; protein targeting to mitochondrion IPR017303; IPR007379; Mitochondrial import inner membrane translocase subunit TIM44 TIMM44 MIMT44 TIM44 Homo sapiens (Human) TR30951_c1_g1_i2 Q32PF3 PCNP_BOVIN 7.00E-22 GO:0007049; GO:0005634; GO:0043161; GO:0016567 cell cycle; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) PCNP Bos taurus (Bovine) TR30952_c0_g1_i1 P15626 GSTM2_MOUSE 2.00E-64 GO:0005737; GO:0004364; GO:0046982; GO:0042803 cytoplasm; glutathione transferase activity; protein heterodimerization activity; protein homodimerization activity IPR010987; IPR004045; IPR004046; IPR003081; IPR012336; Glutathione S-transferase Mu 2 (EC 2.5.1.18) (GST 5-5) (GST class-mu 2) (Glutathione S-transferase pmGT2) Gstm2 Mus musculus (Mouse) TR30952_c0_g1_i4 Q9N0V4 GSTM1_BOVIN 6.00E-61 GO:0005737; GO:0004364 cytoplasm; glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR003081; IPR012336; Glutathione S-transferase Mu 1 (EC 2.5.1.18) (GST class-mu 1) (GSTM1-1) GSTM1 GSTM Bos taurus (Bovine) TR30954_c0_g1_i1 Q9CR24 NUDT8_MOUSE 7.00E-33 GO:0016787; GO:0046872; GO:0005739 hydrolase activity; metal ion binding; mitochondrion IPR000086; IPR015797; "Nucleoside diphosphate-linked moiety X motif 8, mitochondrial (Nudix motif 8) (EC 3.6.1.-)" Nudt8 Mus musculus (Mouse) TR30955_c1_g1_i1 Q1JP75 DCXR_BOVIN 4.00E-25 GO:0042732; GO:0050038; GO:0006739; GO:0005903; GO:0005881; GO:0006006; GO:0016020; GO:0005902; GO:0016655; GO:0051289; GO:0005997 "D-xylose metabolic process; L-xylulose reductase (NADP+) activity; NADP metabolic process; brush border; cytoplasmic microtubule; glucose metabolic process; membrane; microvillus; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; protein homotetramerization; xylulose metabolic process" IPR002198; IPR002347; IPR016040; IPR020904; L-xylulose reductase (XR) (EC 1.1.1.10) (Dicarbonyl/L-xylulose reductase) DCXR Bos taurus (Bovine) TR30955_c1_g1_i2 P94129 ACR1_ACIBI 2.00E-08 GO:0006629; GO:0016620 "lipid metabolic process; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" IPR002198; IPR002347; IPR016040; IPR020904; Fatty acyl-CoA reductase (EC 1.2.1.n2) acr1 Acinetobacter baylyi TR30955_c1_g1_i4 Q1JP75 DCXR_BOVIN 6.00E-25 GO:0042732; GO:0050038; GO:0006739; GO:0005903; GO:0005881; GO:0006006; GO:0016020; GO:0005902; GO:0016655; GO:0051289; GO:0005997 "D-xylose metabolic process; L-xylulose reductase (NADP+) activity; NADP metabolic process; brush border; cytoplasmic microtubule; glucose metabolic process; membrane; microvillus; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; protein homotetramerization; xylulose metabolic process" IPR002198; IPR002347; IPR016040; IPR020904; L-xylulose reductase (XR) (EC 1.1.1.10) (Dicarbonyl/L-xylulose reductase) DCXR Bos taurus (Bovine) TR30957_c0_g1_i1 P56536 KIF5C_RAT 5.00E-31 GO:0005524; GO:0005737; GO:0005871; GO:0051028; GO:0005874; GO:0003777; GO:0007018 Q8IXI2 ATP binding; cytoplasm; kinesin complex; mRNA transport; microtubule; microtubule motor activity; microtubule-based movement IPR027640; IPR019821; IPR001752; IPR027417; Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2) (Fragment) Kif5c Nkhc2 Rattus norvegicus (Rat) TR30957_c1_g1_i1 Q61771 KIF3B_MOUSE 2.00E-158 GO:0005524; GO:0005829; GO:0016939; GO:0005874; GO:0003777; GO:0007018; GO:0090307 ATP binding; cytosol; kinesin II complex; microtubule; microtubule motor activity; microtubule-based movement; spindle assembly involved in mitosis IPR027640; IPR019821; IPR001752; IPR027417; "Kinesin-like protein KIF3B (Microtubule plus end-directed kinesin motor 3B) [Cleaved into: Kinesin-like protein KIF3B, N-terminally processed]" Kif3b Mus musculus (Mouse) TR30958_c1_g1_i1 Q9P6I3 YHG7_SCHPO 2.00E-12 GO:0031362; GO:0051692; GO:0005783; GO:0005789; GO:0046379; GO:0009272; GO:0016021; GO:0008496 "anchored to external side of plasma membrane; cellular oligosaccharide catabolic process; endoplasmic reticulum; endoplasmic reticulum membrane; extracellular polysaccharide metabolic process; fungal-type cell wall biogenesis; integral to membrane; mannan endo-1,6-alpha-mannosidase activity" IPR008928; IPR012341; IPR005198; IPR014480; "Putative mannan endo-1,6-alpha-mannosidase C1198.07c (EC 3.2.1.101) (Endo-alpha-1->6-D-mannanase C1198.07c)" SPBC1198.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR30959_c1_g1_i1 Q8TCT0 CERK1_HUMAN 2.00E-78 GO:0005524; GO:0003951; GO:0001729; GO:0006672; GO:0005737; GO:0004143; GO:0006687; GO:0016021; GO:0000287; GO:0005739; GO:0005634; GO:0005543; GO:0005886; GO:0007205; GO:0044281 ATP binding; NAD+ kinase activity; ceramide kinase activity; ceramide metabolic process; cytoplasm; diacylglycerol kinase activity; glycosphingolipid metabolic process; integral to membrane; magnesium ion binding; mitochondrion; nucleus; phospholipid binding; plasma membrane; protein kinase C-activating G-protein coupled receptor signaling pathway; small molecule metabolic process IPR016064; IPR001206; IPR001849; Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) TR30960_c0_g2_i2 Q5ZKM0 DTBP1_CHICK 6.00E-25 GO:0031083; GO:0031532; GO:0008089; GO:0048490; GO:0030424; GO:0007596; GO:0030054; GO:0043197; GO:0005789; GO:0010008; GO:0030426; GO:0033162; GO:0048812; GO:0005634; GO:0060155; GO:0010628; GO:0001956; GO:0014069; GO:0045211; GO:0060159; GO:0014059; GO:0042383; GO:0016528; GO:0030672 BLOC-1 complex; actin cytoskeleton reorganization; anterograde axon cargo transport; anterograde synaptic vesicle transport; axon; blood coagulation; cell junction; dendritic spine; endoplasmic reticulum membrane; endosome membrane; growth cone; melanosome membrane; neuron projection morphogenesis; nucleus; platelet dense granule organization; positive regulation of gene expression; positive regulation of neurotransmitter secretion; postsynaptic density; postsynaptic membrane; regulation of dopamine receptor signaling pathway; regulation of dopamine secretion; sarcolemma; sarcoplasm; synaptic vesicle membrane IPR007531; Dysbindin (Biogenesis of lysosome-related organelles complex 1 subunit 8) (BLOC-1 subunit 8) (Dysbindin-1) (Dystrobrevin-binding protein 1) DTNBP1 Bloc1s8 RCJMB04_10b8 Gallus gallus (Chicken) TR30962_c0_g1_i1 O65154 KIWI_ARATH 8.00E-14 GO:0003677; GO:0005634; GO:0006355; GO:0003713; GO:0006351 O65155 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent" IPR003173; IPR009044; RNA polymerase II transcriptional coactivator KIWI KIWI At5g09250 T5E8_50 Arabidopsis thaliana (Mouse-ear cress) TR30962_c0_g1_i2 Q5ZK63 TCP4_CHICK 3.00E-15 GO:0003677; GO:0005634; GO:0006355; GO:0003713; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent" IPR003173; IPR009044; Activated RNA polymerase II transcriptional coactivator p15 (SUB1 homolog) SUB1 RPO2TC1 RCJMB04_12p22 Gallus gallus (Chicken) TR30962_c0_g1_i3 P11031 TCP4_MOUSE 2.00E-16 GO:0001205; GO:0005730; GO:0003697; GO:0003713; GO:0005667 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; nucleolus; single-stranded DNA binding; transcription coactivator activity; transcription factor complex IPR003173; IPR009044; Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (SUB1 homolog) (Single-stranded DNA-binding protein p9) (p14) Sub1 Pc4 Rpo2tc1 Mus musculus (Mouse) TR30967_c1_g1_i1 Q91085 VIPR_MELGA 1.00E-49 GO:0016021; GO:0005886; GO:0004999 integral to membrane; plasma membrane; vasoactive intestinal polypeptide receptor activity IPR017981; IPR001879; IPR000832; IPR017983; IPR001571; IPR001771; Vasoactive intestinal polypeptide receptor (VIP receptor) (VIP-R) VIPR1 Meleagris gallopavo (Common turkey) TR30967_c1_g1_i2 Q5FWI2 SCTR_MOUSE 1.00E-58 GO:0004930; GO:0005881; GO:0016021; GO:0005886 G-protein coupled receptor activity; cytoplasmic microtubule; integral to membrane; plasma membrane IPR017981; IPR001879; IPR000832; IPR017983; IPR002144; Secretin receptor (SCT-R) Sctr Mus musculus (Mouse) TR30972_c1_g1_i1 Q09660 CC44_CAEEL 1.00E-28 GO:0020037; GO:0005506; GO:0004497; GO:0016705 "heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Probable cytochrome P450 CYP44 (EC 1.14.-.-) cyp-44A1 ccp-44 cyp44 ZK177.5 Caenorhabditis elegans TR30972_c2_g1_i1 Q28827 CP11A_RABIT 2.00E-09 GO:0006700; GO:0008203; GO:0008386; GO:0020037; GO:0005506; GO:0031966 C21-steroid hormone biosynthetic process; cholesterol metabolic process; cholesterol monooxygenase (side-chain-cleaving) activity; heme binding; iron ion binding; mitochondrial membrane IPR001128; IPR002399; Lipid metabolism; C21-steroid hormone metabolism. "Cholesterol side-chain cleavage enzyme, mitochondrial (EC 1.14.15.6) (CYPXIA1) (Cholesterol desmolase) (Cytochrome P450 11A1) (Cytochrome P450(scc)) (Fragment)" CYP11A1 Oryctolagus cuniculus (Rabbit) TR30974_c1_g1_i1 Q5ZM14 NHRF1_CHICK 2.00E-12 GO:0016055; GO:0032782; GO:0017081; GO:0005737; GO:0012505; GO:0030175; GO:0034635; GO:0031528; GO:2000146; GO:0014067; GO:0010642; GO:0051898; GO:0045859; GO:0070293; GO:0001726 Wnt receptor signaling pathway; bile acid secretion; chloride channel regulator activity; cytoplasm; endomembrane system; filopodium; glutathione transport; microvillus membrane; negative regulation of cell motility; negative regulation of phosphatidylinositol 3-kinase cascade; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein kinase B signaling cascade; regulation of protein kinase activity; renal absorption; ruffle IPR015098; IPR017300; IPR001478; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) SLC9A3R1 NHERF NHERF1 RCJMB04_3g21 Gallus gallus (Chicken) TR30974_c1_g2_i1 Q8K4V4 SNX27_RAT 6.00E-101 GO:0005829; GO:0005769; GO:0031901; GO:0001772; GO:0006886; GO:0007399; GO:0032266; GO:0042493; GO:1990126; GO:0007165 "cytosol; early endosome; early endosome membrane; immunological synapse; intracellular protein transport; nervous system development; phosphatidylinositol-3-phosphate binding; response to drug; retrograde transport, endosome to plasma membrane; signal transduction" IPR001478; IPR001683; IPR000159; Sorting nexin-27 (MAP-responsive gene protein) (Methamphetamine-responsive transcript 1 protein) (PDZ-protein Mrt1) Snx27 Mrt1 Rattus norvegicus (Rat) TR30976_c0_g1_i1 Q5M856 SPC25_RAT 2.00E-16 GO:0031262; GO:0051301; GO:0007059; GO:0000777; GO:0007067; GO:0007052; GO:0005634 Ndc80 complex; cell division; chromosome segregation; condensed chromosome kinetochore; mitosis; mitotic spindle organization; nucleus IPR013255; Kinetochore protein Spc25 Spc25 Spbc25 Rattus norvegicus (Rat) TR3098_c0_g2_i1 P38822 BZZ1_YEAST 5.00E-15 GO:0030479; GO:0007015; GO:0006897; GO:0009651 P40563; P38266; P53933; Q12446; Q12342; Q04439; P40453; Q08989 actin cortical patch; actin filament organization; endocytosis; response to salt stress IPR001060; IPR001452; Protein BZZ1 (LAS17-binding protein 7) BZZ1 LSB7 YHR114W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR30981_c0_g1_i2 Q5PQ59 ALKB6_XENLA 2.00E-61 GO:0005737; GO:0046872; GO:0005634; GO:0016706 "cytoplasm; metal ion binding; nucleus; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" IPR027450; IPR005123; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 6) alkbh6 Xenopus laevis (African clawed frog) TR30982_c1_g1_i1 O77237 PELI_DROME 6.00E-177 GO:0008063; GO:0006955; GO:0019207 Toll signaling pathway; immune response; kinase regulator activity IPR006800; Protein pellino Pli CG5212 Drosophila melanogaster (Fruit fly) TR30985_c2_g1_i2 Q5C9L6 CNMT_THLFG 4.00E-76 GO:0030794; GO:0005737; GO:0008610 (S)-coclaurine-N-methyltransferase activity; cytoplasm; lipid biosynthetic process IPR003333; (S)-coclaurine N-methyltransferase (TfCNMT) (EC 2.1.1.140) Thalictrum flavum subsp. glaucum (Yellow meadow rue) TR30988_c0_g1_i3 Q8VIH3 S28A3_RAT 5.00E-147 GO:0016021; GO:0001882; GO:0005415; GO:0001895 integral to membrane; nucleoside binding; nucleoside:sodium symporter activity; retina homeostasis IPR008276; IPR018270; IPR011657; IPR011642; IPR002668; Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (rCNT3) Slc28a3 Cnt3 Rattus norvegicus (Rat) TR30989_c0_g1_i1 Q1MTN8 YGC1_SCHPO 1.00E-24 GO:0005730; GO:0043234 nucleolus; protein complex IPR013026; IPR011990; IPR019734; UPF0661 TPR repeat-containing protein C16D10.01c SPBC16D10.01c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR30990_c1_g2_i1 Q6P1D7 SLX4_MOUSE 3.00E-07 GO:0048257; GO:0017108; GO:0010792; GO:0006260; GO:0070522; GO:0048476; GO:0033557; GO:0008821; GO:0000724; GO:0008047; GO:0000790; GO:0000784; GO:0006289 "3'-flap endonuclease activity; 5'-flap endonuclease activity; DNA double-strand break processing involved in repair via single-strand annealing; DNA replication; ERCC4-ERCC1 complex; Holliday junction resolvase complex; Slx1-Slx4 complex; crossover junction endodeoxyribonuclease activity; double-strand break repair via homologous recombination; enzyme activator activity; nuclear chromatin; nuclear chromosome, telomeric region; nucleotide-excision repair" IPR000210; IPR011333; IPR013069; IPR018574; Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) Slx4 Btbd12 Mus musculus (Mouse) TR30991_c4_g1_i1 P85008 DEF1_CRAVI 7.00E-06 GO:0050829; GO:0050830; GO:0045087 defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; innate immune response IPR001542; IPR003614; Defensin-1 (American oyster defensin) (AOD) Crassostrea virginica (Eastern oyster) TR30992_c0_g1_i1 Q54V47 ARFJ_DICDI 1.00E-45 GO:0005525; GO:0005794; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor J arrJ DDB_G0280621 Dictyostelium discoideum (Slime mold) TR30993_c1_g1_i1 Q8VI63 MOB2_MOUSE 2.00E-69 GO:0030036; GO:0005737; GO:0046872; GO:0044306; GO:0005634; GO:0048471; GO:0010976; GO:0001934 actin cytoskeleton organization; cytoplasm; metal ion binding; neuron projection terminus; nucleus; perinuclear region of cytoplasm; positive regulation of neuron projection development; positive regulation of protein phosphorylation IPR005301; MOB kinase activator 2 (Mob2 homolog) (Mps one binder kinase activator-like 2) (Ovary-specific MOB-like protein) Mob2 Mmh Mus musculus (Mouse) TR30993_c1_g1_i3 Q54XJ0 MOB1A_DICDI 1.00E-45 GO:0046872 metal ion binding IPR005301; MOB kinase activator-like 1 homolog A (Mps one binder kinase activator-like 1 homolog A) mobA DDB_G0278907 Dictyostelium discoideum (Slime mold) TR30995_c1_g2_i1 P09926 SURF2_MOUSE 6.00E-25 IPR008833; Surfeit locus protein 2 (Surf-2) Surf2 Surf-2 Mus musculus (Mouse) TR30995_c1_g2_i2 P09926 SURF2_MOUSE 4.00E-25 IPR008833; Surfeit locus protein 2 (Surf-2) Surf2 Surf-2 Mus musculus (Mouse) TR30996_c0_g1_i1 O88794 PNPO_RAT 8.00E-76 GO:0010181; GO:0004733; GO:0008615 FMN binding; pyridoxamine-phosphate oxidase activity; pyridoxine biosynthetic process IPR000659; IPR019740; IPR011576; IPR019576; IPR012349; Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1. Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1. Pyridoxine-5'-phosphate oxidase (EC 1.4.3.5) (Pyridoxamine-phosphate oxidase) Pnpo Rattus norvegicus (Rat) TR30996_c0_g1_i2 B0C079 PDXH_ACAM1 5.00E-63 GO:0010181; GO:0042823; GO:0004733; GO:0008615 FMN binding; pyridoxal phosphate biosynthetic process; pyridoxamine-phosphate oxidase activity; pyridoxine biosynthetic process IPR000659; IPR019740; IPR011576; IPR019576; IPR012349; Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1. Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1. Pyridoxine/pyridoxamine 5'-phosphate oxidase (EC 1.4.3.5) (PNP/PMP oxidase) (PNPOx) (Pyridoxal 5'-phosphate synthase) pdxH AM1_4597 Acaryochloris marina (strain MBIC 11017) TR30998_c0_g1_i1 Q5XJQ7 OSR1_DANRE 2.00E-15 GO:0035779; GO:0048389; GO:0048382; GO:0046872; GO:0000122; GO:0003676; GO:0005634; GO:0033339; GO:0035777; GO:0035775; GO:0035778; GO:0035776; GO:0006351 "angioblast cell differentiation; intermediate mesoderm development; mesendoderm development; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleic acid binding; nucleus; pectoral fin development; pronephric distal tubule development; pronephric glomerulus morphogenesis; pronephric nephron tubule epithelial cell differentiation; pronephric proximal tubule development; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Protein odd-skipped-related 1 (zOsr1) osr1 si:dkey-199e17.1 zgc:101674 Danio rerio (Zebrafish) (Brachydanio rerio) TR30998_c0_g1_i2 Q60542 ZEB1_MESAU 1.00E-18 GO:0070888; GO:0046872; GO:0045892; GO:0005634; GO:0045666; GO:0043565; GO:0003700; GO:0006351 "E-box binding; metal ion binding; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of neuron differentiation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008598; IPR001356; IPR009057; IPR007087; IPR015880; IPR013087; Zinc finger E-box-binding homeobox 1 (Transcription factor 8) (TCF-8) (Zinc finger protein BZP) ZEB1 BZP TCF8 Mesocricetus auratus (Golden hamster) TR30998_c0_g2_i1 A6NK53 ZN233_HUMAN 2.00E-71 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 233 ZNF233 Homo sapiens (Human) TR30998_c0_g2_i2 P17040 ZSC20_HUMAN 2.00E-53 GO:0003677; GO:0003682; GO:0046872; GO:0005739; GO:0005634; GO:0003700; GO:0006351 "DNA binding; chromatin binding; metal ion binding; mitochondrion; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR008916; IPR001005; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 20 (Zinc finger protein 31) (Zinc finger protein 360) (Zinc finger protein KOX29) ZSCAN20 KOX29 ZNF31 ZNF360 Homo sapiens (Human) TR30998_c0_g2_i3 P53968 CRZ1_YEAST 7.00E-22 GO:0001077; GO:0006038; GO:0071483; GO:0000987; GO:0005737; GO:0046872; GO:0005634; GO:2001040; GO:0061423; GO:1900622; GO:0007329; GO:0061422; GO:0061400; GO:0061404; GO:0097301 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; cell wall chitin biosynthetic process; cellular response to blue light; core promoter proximal region sequence-specific DNA binding; cytoplasm; metal ion binding; nucleus; positive regulation of cellular response to drug; positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling; positive regulation of transcription from RNA polymerase II promoter by pheromones; positive regulation of transcription from RNA polymerase II promoter in response to alkalinity; positive regulation of transcription from RNA polymerase II promoter in response to calcium ion; positive regulation of transcription from RNA polymerase II promoter in response to increased salt; regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter IPR007087; IPR015880; IPR013087; Transcriptional regulator CRZ1 CRZ1 HAL8 TCN1 YNL027W N2760 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR30998_c0_g2_i4 Q00911 EGR4_RAT 3.00E-22 GO:0000977; GO:0071320; GO:0071371; GO:0071363; GO:0005737; GO:0046872; GO:0043066; GO:0005634; GO:0045944; GO:0003700; GO:0006351 "RNA polymerase II regulatory region sequence-specific DNA binding; cellular response to cAMP; cellular response to gonadotropin stimulus; cellular response to growth factor stimulus; cytoplasm; metal ion binding; negative regulation of apoptotic process; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Early growth response protein 4 (EGR-4) (Early response protein NGFI-C) (Nerve growth factor-induced protein C) (NGFI-C) Egr4 Egr-4 Ngfic Rattus norvegicus (Rat) TR30998_c0_g2_i5 Q3SWU4 ZBT44_RAT 4.00E-12 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 44 (BTB/POZ domain-containing protein 15) Zbtb44 Btbd15 Rattus norvegicus (Rat) TR30999_c0_g1_i1 Q921L7 HEMK1_MOUSE 1.00E-65 GO:0005739; GO:0003676; GO:0008276 mitochondrion; nucleic acid binding; protein methyltransferase activity IPR002052; IPR004556; IPR019874; HemK methyltransferase family member 1 (EC 2.1.1.-) Hemk1 Mus musculus (Mouse) TR3100_c0_g2_i1 Q8WQI5 RS8_SPOFR 2.00E-97 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001047; IPR022309; IPR018283; 40S ribosomal protein S8 RpS8 Spodoptera frugiperda (Fall armyworm) TR31002_c0_g1_i1 Q3MJ13 WDR72_HUMAN 3.00E-07 IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 72 WDR72 Homo sapiens (Human) TR31002_c0_g2_i1 Q920I9 WDR7_MOUSE 7.00E-14 IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 7 (TGF-beta resistance-associated protein TRAG) Wdr7 Kiaa0541 Trag Mus musculus (Mouse) TR31002_c1_g1_i1 Q6DIY8 M17L2_XENTR 1.00E-22 GO:0016021 integral to membrane IPR007248; Mpv17-like protein 2 mpv17l2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31003_c1_g2_i1 Q8WTR4 GDPD5_HUMAN 3.00E-61 GO:0021895; GO:0012505; GO:0006071; GO:0008889; GO:0030426; GO:0016021; GO:0006629; GO:0045746; GO:0031175; GO:0048471; GO:0048505; GO:0021522 cerebral cortex neuron differentiation; endomembrane system; glycerol metabolic process; glycerophosphodiester phosphodiesterase activity; growth cone; integral to membrane; lipid metabolic process; negative regulation of Notch signaling pathway; neuron projection development; perinuclear region of cytoplasm; regulation of timing of cell differentiation; spinal cord motor neuron differentiation IPR004129; IPR017946; Glycerophosphodiester phosphodiesterase domain-containing protein 5 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 2) GDPD5 GDE2 PP6037 PP9363 UNQ1850/PRO3580 Homo sapiens (Human) TR31004_c0_g1_i1 Q5BL35 SPOLA_DANRE 4.00E-13 GO:0031463; GO:0031397; GO:0005634; GO:0043161; GO:0016567 Cul3-RING ubiquitin ligase complex; negative regulation of protein ubiquitination; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination IPR000210; IPR011333; IPR013069; IPR002083; IPR008974; Protein modification; protein ubiquitination. Speckle-type POZ protein-like A (HIB homolog 2) spopla spopl zgc:101524 Danio rerio (Zebrafish) (Brachydanio rerio) TR31007_c1_g2_i1 P51650 SSDH_RAT 0 GO:0051287; GO:0031406; GO:0007417; GO:0009450; GO:0005739; GO:0006105; GO:0004777; GO:0009013 NAD binding; carboxylic acid binding; central nervous system development; gamma-aminobutyric acid catabolic process; mitochondrion; succinate metabolic process; succinate-semialdehyde dehydrogenase (NAD+) activity; succinate-semialdehyde dehydrogenase [NAD(P)+] activity IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR010102; Amino-acid degradation; 4-aminobutanoate degradation. "Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase)" Aldh5a1 Ssadh Rattus norvegicus (Rat) TR31007_c1_g2_i3 Q9US47 SSDH1_SCHPO 2.00E-168 GO:0005829; GO:0009450; GO:0006540; GO:0009013 cytosol; gamma-aminobutyric acid catabolic process; glutamate decarboxylation to succinate; succinate-semialdehyde dehydrogenase [NAD(P)+] activity IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR010102; Amino-acid degradation; 4-aminobutanoate degradation. Putative succinate-semialdehyde dehydrogenase C1002.12c [NADP(+)] (SSDH) (EC 1.2.1.16) SPAC1002.12c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR31008_c0_g1_i1 F7B645 TM231_XENTR 2.00E-47 GO:0036038; GO:0042384; GO:0060170; GO:0016021; GO:0007224 TCTN-B9D complex; cilium assembly; cilium membrane; integral to membrane; smoothened signaling pathway IPR019306; Transmembrane protein 231 tmem231 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31009_c1_g1_i1 Q8AWB6 S35B1_CHICK 7.00E-106 GO:0008643; GO:0005789; GO:0016021; GO:0055085 carbohydrate transport; endoplasmic reticulum membrane; integral to membrane; transmembrane transport IPR013657; Solute carrier family 35 member B1 (Endoplasmic reticulum nucleotide sugar transporter 1) SLC35B1 ERNST1 Gallus gallus (Chicken) TR31010_c1_g1_i1 A4IF63 TRIM2_BOVIN 3.00E-26 GO:0005737; GO:0043523; GO:0004842; GO:0008270 cytoplasm; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) TR31010_c1_g1_i3 Q9U489 LIN41_CAEEL 2.00E-17 GO:0005737; GO:0009957; GO:0007276; GO:0044268; GO:0042787; GO:0040034; GO:0045604; GO:0045138; GO:0004842; GO:0008270 "cytoplasm; epidermal cell fate specification; gamete generation; multicellular organismal protein metabolic process; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of development, heterochronic; regulation of epidermal cell differentiation; tail tip morphogenesis; ubiquitin-protein ligase activity; zinc ion binding" IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; Protein lin-41 (Abnormal cell lineage protein 41) lin-41 C12C8.3 Caenorhabditis elegans TR31012_c2_g1_i1 Q8K0U4 HS12A_MOUSE 1.00E-84 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR31012_c2_g1_i3 Q6L0S7 DNAK_PICTO 3.00E-07 GO:0005524; GO:0006457 ATP binding; protein folding IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK PTO0840 Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) TR31012_c2_g1_i5 Q8K0U4 HS12A_MOUSE 1.00E-84 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR31013_c0_g4_i1 Q9D1C2 CBY1_MOUSE 1.00E-21 GO:0005794; GO:0055007; GO:0042384; GO:0045444; GO:0005932; GO:0090090; GO:0045892; GO:0016607; GO:0008104; GO:0005802 "Golgi apparatus; cardiac muscle cell differentiation; cilium assembly; fat cell differentiation; microtubule basal body; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of transcription, DNA-dependent; nuclear speck; protein localization; trans-Golgi network" IPR028118; "Protein chibby homolog 1 (Cytosolic leucine-rich protein) (PIGEA-14) (PKD2 interactor, Golgi and endoplasmic reticulum-associated 1)" Cby1 Cby Pgea1 Mus musculus (Mouse) TR31017_c1_g2_i1 Q8N0N3 BGBP_PENMO 1.00E-84 GO:0001872; GO:0005975; GO:0005576; GO:0004553; GO:0045087 "(1->3)-beta-D-glucan binding; carbohydrate metabolic process; extracellular region; hydrolase activity, hydrolyzing O-glycosyl compounds; innate immune response" IPR008985; IPR013320; IPR000757; "Beta-1,3-glucan-binding protein (GBP)" Penaeus monodon (Giant tiger prawn) TR31017_c1_g2_i3 P23903 E13B_BACCI 1.00E-20 GO:0005975; GO:0005576; GO:0042973 "carbohydrate metabolic process; extracellular region; glucan endo-1,3-beta-D-glucosidase activity" IPR008985; IPR013320; IPR000757; IPR008263; "Glucan endo-1,3-beta-glucosidase A1 (EC 3.2.1.39) ((1->3)-beta-glucan endohydrolase) ((1->3)-beta-glucanase A1)" glcA Bacillus circulans TR31018_c1_g1_i1 Q7T0Y4 CC164_XENLA 0 GO:0070286; GO:0060285; GO:0035085; GO:0005856 axonemal dynein complex assembly; ciliary cell motility; cilium axoneme; cytoskeleton Dynein regulatory complex protein 1 (Coiled-coil domain-containing protein 164) drc1 ccdc164 Xenopus laevis (African clawed frog) TR31019_c0_g1_i2 Q6ZUT1 CK057_HUMAN 8.00E-14 Uncharacterized protein C11orf57 C11orf57 Homo sapiens (Human) TR31020_c0_g1_i1 Q5RFJ0 COA5_PONAB 2.00E-13 GO:0005739 mitochondrion IPR018793; Cytochrome c oxidase assembly factor 5 Coa5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR31021_c0_g1_i1 O07552 NHAX_BACSU 6.00E-09 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Stress response protein NhaX nhaX yheK BSU09690 Bacillus subtilis (strain 168) TR31021_c0_g1_i2 P42297 YXIE_BACSU 1.00E-08 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein YxiE (USP YxiE) yxiE BSU39250 N17E Bacillus subtilis (strain 168) TR31021_c0_g1_i5 P42297 YXIE_BACSU 5.00E-07 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein YxiE (USP YxiE) yxiE BSU39250 N17E Bacillus subtilis (strain 168) TR31022_c8_g1_i1 Q5PYH7 DLG2_DANRE 3.00E-24 GO:0010923; GO:0050808; GO:0007268 negative regulation of phosphatase activity; synapse organization; synaptic transmission IPR008145; IPR008144; IPR020590; IPR016313; IPR019590; IPR027417; IPR001478; IPR019583; IPR011511; IPR001452; Disks large homolog 2 (Postsynaptic density protein 93) (PSD-93) dlg2 Danio rerio (Zebrafish) (Brachydanio rerio) TR31022_c8_g1_i2 Q9QZR8 PDZD2_RAT 2.00E-23 GO:0045177; GO:0007155; GO:0005911; GO:0005783; GO:0005576; GO:0035556; GO:0043005; GO:0005634; GO:0014069 apical part of cell; cell adhesion; cell-cell junction; endoplasmic reticulum; extracellular region; intracellular signal transduction; neuron projection; nucleus; postsynaptic density IPR001478; PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Plakophilin-related armadillo repeat protein-interacting PDZ protein) [Cleaved into: Processed PDZ domain-containing protein 2] Pdzd2 Papin Pdzk3 Pin1 Rattus norvegicus (Rat) TR31026_c3_g1_i1 Q5R7B0 RPP29_PONAB 2.00E-49 GO:0003723; GO:0006379; GO:0005655; GO:0006364; GO:0000172; GO:0004526; GO:0008033 RNA binding; mRNA cleavage; nucleolar ribonuclease P complex; rRNA processing; ribonuclease MRP complex; ribonuclease P activity; tRNA processing IPR002730; IPR016848; IPR023534; Ribonuclease P protein subunit p29 (EC 3.1.26.5) POP4 RPP29 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR31028_c0_g1_i2 Q640Z9 LRC14_XENLA 4.00E-21 IPR001611; IPR026292; Leucine-rich repeat-containing protein 14 lrrc14 Xenopus laevis (African clawed frog) TR31031_c0_g1_i1 Q8IY51 TIGD4_HUMAN 2.00E-18 GO:0003677; GO:0005634 DNA binding; nucleus IPR004875; IPR009057; IPR006600; IPR007889; Tigger transposable element-derived protein 4 TIGD4 Homo sapiens (Human) TR31033_c0_g1_i1 Q3U2S4 OTUD5_MOUSE 5.00E-110 GO:0071108; GO:0070536; GO:0006508; GO:0032496; GO:0004843 protein K48-linked deubiquitination; protein K63-linked deubiquitination; proteolysis; response to lipopolysaccharide; ubiquitin-specific protease activity IPR003323; OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA) Otud5 DXImx46e Sfc7 Mus musculus (Mouse) TR31035_c0_g1_i1 Q9CXT6 KDM8_MOUSE 2.00E-16 GO:0000086; GO:0003682; GO:0051864; GO:0046872; GO:0005634; GO:0045893; GO:0006351 "G2/M transition of mitotic cell cycle; chromatin binding; histone demethylase activity (H3-K36 specific); metal ion binding; nucleus; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003347; Lysine-specific demethylase 8 (EC 1.14.11.27) (JmjC domain-containing protein 5) (Jumonji domain-containing protein 5) Kdm8 Jmjd5 Mus musculus (Mouse) TR31035_c0_g1_i3 P0C872 JMJD7_MOUSE 6.00E-29 IPR003347; JmjC domain-containing protein 7 (Jumonji domain-containing protein 7) Jmjd7 Mus musculus (Mouse) TR31035_c0_g1_i4 B5XF11 KDM8_SALSA 7.00E-18 GO:0000086; GO:0003682; GO:0051864; GO:0046872; GO:0005634; GO:0045893; GO:0006351 "G2/M transition of mitotic cell cycle; chromatin binding; histone demethylase activity (H3-K36 specific); metal ion binding; nucleus; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003347; Lysine-specific demethylase 8 (EC 1.14.11.27) (JmjC domain-containing protein 5) (Jumonji domain-containing protein 5) kdm8 jmjd5 Salmo salar (Atlantic salmon) TR31037_c0_g2_i1 A9CPT4 TDRD1_ORYLA 3.00E-10 GO:0043046; GO:0031047; GO:0007281; GO:0007126; GO:0046872; GO:0007275; GO:0071546; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; gene silencing by RNA; germ cell development; meiosis; metal ion binding; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002999; IPR002893; Tudor domain-containing protein 1 tdrd1 Oryzias latipes (Medaka fish) (Japanese ricefish) TR31037_c0_g2_i2 Q98SP8 EPABA_XENLA 3.00E-10 GO:0043009; GO:0005737; GO:0006397; GO:0048255; GO:0060212; GO:0000166; GO:0008143; GO:0006412 O73932; A8KBF3 chordate embryonic development; cytoplasm; mRNA processing; mRNA stabilization; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; nucleotide binding; poly(A) RNA binding; translation IPR012677; IPR006515; IPR002004; IPR000504; Embryonic polyadenylate-binding protein A (Embryonic poly(A)-binding protein A) (ePAB-A) (ePABP-A) (XePABP-A) epabp-a epab Xenopus laevis (African clawed frog) TR31037_c0_g3_i1 Q13310 PABP4_HUMAN 7.00E-11 GO:0006401; GO:0006396; GO:0007596; GO:0010494; GO:0000166; GO:0005634; GO:0008143; GO:0008266; GO:0006412 Q8WV24 RNA catabolic process; RNA processing; blood coagulation; cytoplasmic stress granule; nucleotide binding; nucleus; poly(A) RNA binding; poly(U) RNA binding; translation IPR012677; IPR006515; IPR002004; IPR000504; Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) TR31037_c1_g1_i1 Q99MW1 STK31_MOUSE 2.00E-43 GO:0005524; GO:0016788; GO:0003676; GO:0004674 "ATP binding; hydrolase activity, acting on ester bonds; nucleic acid binding; protein serine/threonine kinase activity" IPR011009; IPR000719; IPR016071; IPR002999; Serine/threonine-protein kinase 31 (EC 2.7.11.1) Stk31 Mus musculus (Mouse) TR31037_c1_g1_i2 Q8SSY6 SPKUL_DICDI 1.00E-06 GO:0005524; GO:0004674; GO:0004842 ATP binding; protein serine/threonine kinase activity; ubiquitin-protein ligase activity IPR000569; IPR011009; IPR000719; IPR009091; IPR000408; IPR008271; Protein modification; protein ubiquitination. Bifunctional serine/threonine-protein kinase/NEDD4-like E3 ubiquitin-protein ligase [Includes: Probable serine/threonine-protein kinase DDB_G0276527 (EC 2.7.11.1); Probable NEDD4-like E3 ubiquitin-protein ligase DDB_G0276527 (EC 6.3.2.-)] DDB_G0276527 Dictyostelium discoideum (Slime mold) TR31039_c0_g1_i1 A9A916 PAN_METM6 4.00E-37 GO:0005524; GO:0006200; GO:0016887; GO:0005737; GO:0010498; GO:0022623; GO:0043335 ATP binding; ATP catabolic process; ATPase activity; cytoplasm; proteasomal protein catabolic process; proteasome-activating nucleotidase complex; protein unfolding IPR005937; IPR003593; IPR003959; IPR003960; IPR023501; IPR027417; Proteasome-activating nucleotidase (PAN) (Proteasomal ATPase) (Proteasome regulatory ATPase) (Proteasome regulatory particle) pan MmarC6_1024 Methanococcus maripaludis (strain C6 / ATCC BAA-1332) TR31039_c0_g1_i2 Q54PT2 VPS4_DICDI 4.00E-93 GO:0005524; GO:0016197; GO:0005768; GO:0031902; GO:0017111; GO:0015031 ATP binding; endosomal transport; endosome; late endosome membrane; nucleoside-triphosphatase activity; protein transport IPR003593; IPR003959; IPR003960; IPR007330; IPR027417; IPR015415; Vacuolar protein sorting-associated protein 4 (EC 3.6.4.6) vps4 DDB_G0284347 Dictyostelium discoideum (Slime mold) TR31040_c1_g1_i1 P36633 ABP1_RAT 1.00E-111 GO:0009308; GO:0005261; GO:0097185; GO:0071280; GO:0035874; GO:0071420; GO:0005507; GO:0052597; GO:0008144; GO:0005615; GO:0008201; GO:0052598; GO:0052599; GO:0005886; GO:0008131; GO:0052600; GO:0032403; GO:0048038; GO:0004872; GO:0046677; GO:0042493; GO:0005923; GO:0008270 "amine metabolic process; cation channel activity; cellular response to azide; cellular response to copper ion; cellular response to copper ion starvation; cellular response to histamine; copper ion binding; diamine oxidase activity; drug binding; extracellular space; heparin binding; histamine oxidase activity; methylputrescine oxidase activity; plasma membrane; primary amine oxidase activity; propane-1,3-diamine oxidase activity; protein complex binding; quinone binding; receptor activity; response to antibiotic; response to drug; tight junction; zinc ion binding" IPR000269; IPR015798; IPR016182; IPR015800; IPR015801; IPR015802; Amiloride-sensitive amine oxidase [copper-containing] (DAO) (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase) Aoc1 Abp1 Rattus norvegicus (Rat) TR31042_c0_g1_i1 Q9DAK2 PACRG_MOUSE 9.00E-120 GO:0044297; GO:0005739; GO:0097225; GO:0007286 cell body; mitochondrion; sperm midpiece; spermatid development IPR019399; Parkin coregulated gene protein homolog (Hypertension-related protein 1-like protein) (PARK2 coregulated gene protein) Pacrg Mus musculus (Mouse) TR31046_c0_g1_i1 Q8LAD0 PDX2_ARATH 2.00E-48 GO:0005829; GO:0004359; GO:0006541; GO:0042823; GO:0008615; GO:0016740; GO:0042819 cytosol; glutaminase activity; glutamine metabolic process; pyridoxal phosphate biosynthetic process; pyridoxine biosynthetic process; transferase activity; vitamin B6 biosynthetic process IPR002161; IPR021196; Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis. Pyridoxal biosynthesis protein PDX2 (EC 2.6.-.-) (Probable glutamine amidotransferase) (AtPDX2) (Protein EMBRYO DEFECTIVE 2407) PDX2 EMB2407 At5g60540 muf9.190 Arabidopsis thaliana (Mouse-ear cress) TR31048_c2_g2_i1 E9Q555 RN213_MOUSE 3.00E-30 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) Rnf213 Mus musculus (Mouse) TR31049_c1_g1_i3 Q6P3D0 NUD16_MOUSE 2.00E-41 GO:0005525; GO:0046709; GO:1901641; GO:1901639; GO:1901640; GO:0006382; GO:0051276; GO:0050897; GO:0005737; GO:0035863; GO:0035870; GO:0050072; GO:0003729; GO:0006402; GO:0000287; GO:0030145; GO:0008235; GO:2000233; GO:0005730; GO:0005654; GO:0090068; GO:0008284; GO:2000781; GO:0042803; GO:0030515; GO:0016077 GTP binding; IDP catabolic process; ITP binding; XDP catabolic process; XTP binding; adenosine to inosine editing; chromosome organization; cobalt ion binding; cytoplasm; dITP catabolic process; dITP diphosphatase activity; m7G(5')pppN diphosphatase activity; mRNA binding; mRNA catabolic process; magnesium ion binding; manganese ion binding; metalloexopeptidase activity; negative regulation of rRNA processing; nucleolus; nucleoplasm; positive regulation of cell cycle process; positive regulation of cell proliferation; positive regulation of double-strand break repair; protein homodimerization activity; snoRNA binding; snoRNA catabolic process IPR000086; IPR015797; U8 snoRNA-decapping enzyme (EC 3.6.1.62) (IDP phosphatase) (IDPase) (EC 3.6.1.-) (Inosine diphosphate phosphatase) (Nucleoside diphosphate-linked moiety X motif 16) (Nudix motif 16) (m7GpppN-mRNA hydrolase) Nudt16 Mus musculus (Mouse) TR31051_c0_g2_i1 O88967 YMEL1_MOUSE 0 GO:0005524; GO:0008283; GO:0016021; GO:0046872; GO:0004222; GO:0006515; GO:0005743; GO:0007005; GO:0017111 ATP binding; cell proliferation; integral to membrane; metal ion binding; metalloendopeptidase activity; misfolded or incompletely synthesized protein catabolic process; mitochondrial inner membrane; mitochondrion organization; nucleoside-triphosphatase activity IPR003593; IPR003959; IPR003960; IPR005936; IPR027417; IPR000642; ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (YME1-like protein 1) Yme1l1 Mus musculus (Mouse) TR31051_c0_g2_i2 O88967 YMEL1_MOUSE 0 GO:0005524; GO:0008283; GO:0016021; GO:0046872; GO:0004222; GO:0006515; GO:0005743; GO:0007005; GO:0017111 ATP binding; cell proliferation; integral to membrane; metal ion binding; metalloendopeptidase activity; misfolded or incompletely synthesized protein catabolic process; mitochondrial inner membrane; mitochondrion organization; nucleoside-triphosphatase activity IPR003593; IPR003959; IPR003960; IPR005936; IPR027417; IPR000642; ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (YME1-like protein 1) Yme1l1 Mus musculus (Mouse) TR31052_c1_g1_i1 Q6R653 UN5CL_MOUSE 2.00E-12 GO:0005737; GO:0016021; GO:0007165 cytoplasm; integral to membrane; signal transduction IPR011029; IPR000488; IPR000906; UNC5C-like protein (Protein unc-5 homolog C-like) (ZU5 and death domain-containing protein) Unc5cl Zud Mus musculus (Mouse) TR31053_c0_g2_i1 Q9WTN6 S22AL_MOUSE 7.00E-64 GO:0005524; GO:0015226; GO:0016021; GO:0031231 ATP binding; carnitine transmembrane transporter activity; integral to membrane; intrinsic to peroxisomal membrane IPR020846; IPR016196; IPR004749; IPR005828; IPR005829; Solute carrier family 22 member 21 (Organic cation/carnitine transporter 3) (Solute carrier family 22 member 9) Slc22a21 Octn3 Slc22a9 Mus musculus (Mouse) TR31055_c1_g1_i1 Q5U595 ZRN1A_XENLA 3.00E-09 GO:0016055; GO:0016477; GO:0005737; GO:0007010; GO:0005634; GO:0030177; GO:0035523; GO:1990168; GO:0070536; GO:0006508; GO:0022604; GO:0004221; GO:0004843; GO:0008270 Wnt receptor signaling pathway; cell migration; cytoplasm; cytoskeleton organization; nucleus; positive regulation of Wnt receptor signaling pathway; protein K29-linked deubiquitination; protein K33-linked deubiquitination; protein K63-linked deubiquitination; proteolysis; regulation of cell morphogenesis; ubiquitin thiolesterase activity; ubiquitin-specific protease activity; zinc ion binding IPR003323; IPR001876; Ubiquitin thioesterase zranb1-A (EC 3.4.19.12) (Zinc finger Ran-binding domain-containing protein 1A) zranb1-a Xenopus laevis (African clawed frog) TR31055_c1_g1_i3 Q6GQQ9 OTU7B_HUMAN 2.00E-92 GO:0003677; GO:0005737; GO:0015630; GO:0002385; GO:0043124; GO:0005634; GO:0035871; GO:0071108; GO:0070536; GO:0006508; GO:0004221; GO:0004843; GO:0008270 Q8IVM0; Q99497 DNA binding; cytoplasm; microtubule cytoskeleton; mucosal immune response; negative regulation of I-kappaB kinase/NF-kappaB cascade; nucleus; protein K11-linked deubiquitination; protein K48-linked deubiquitination; protein K63-linked deubiquitination; proteolysis; ubiquitin thiolesterase activity; ubiquitin-specific protease activity; zinc ion binding IPR003323; IPR002653; OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) OTUD7B ZA20D1 Homo sapiens (Human) TR31058_c1_g1_i1 Q80UW2 FBX2_MOUSE 3.00E-32 GO:0030433; GO:0019005; GO:0031146; GO:0001540; GO:0030246; GO:0005829; GO:0043197; GO:0005783; GO:0001948; GO:0006516; GO:0031090; GO:0016567; GO:0031396 ER-associated protein catabolic process; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; beta-amyloid binding; carbohydrate binding; cytosol; dendritic spine; endoplasmic reticulum; glycoprotein binding; glycoprotein catabolic process; organelle membrane; protein ubiquitination; regulation of protein ubiquitination IPR007397; IPR001810; IPR008979; Protein modification; protein ubiquitination. F-box only protein 2 Fbxo2 Fbs1 Fbx2 Mus musculus (Mouse) TR31058_c1_g1_i2 Q9H4M3 FBX44_HUMAN 7.00E-36 GO:0019005; GO:0030163 SCF ubiquitin ligase complex; protein catabolic process IPR007397; IPR001810; IPR008979; F-box only protein 44 (F-box protein FBX30) (F-box/G-domain protein 3) FBXO44 FBG3 FBX30 FBX44 FBX6A FBXO6A Homo sapiens (Human) TR31058_c1_g1_i3 Q9H4M3 FBX44_HUMAN 7.00E-36 GO:0019005; GO:0030163 SCF ubiquitin ligase complex; protein catabolic process IPR007397; IPR001810; IPR008979; F-box only protein 44 (F-box protein FBX30) (F-box/G-domain protein 3) FBXO44 FBG3 FBX30 FBX44 FBX6A FBXO6A Homo sapiens (Human) TR31060_c4_g2_i2 O96185 YPF08_PLAF7 3.00E-06 Uncharacterized protein PFB0460c PFB0460c Plasmodium falciparum (isolate 3D7) TR31061_c2_g1_i1 A4IFB6 CNOTA_BOVIN 4.00E-164 GO:0030014 CCR4-NOT complex IPR011990; IPR001440; IPR019734; CCR4-NOT transcription complex subunit 10 CNOT10 Bos taurus (Bovine) TR31066_c0_g1_i1 P10620 MGST1_HUMAN 2.00E-38 GO:0033327; GO:0045177; GO:0071449; GO:0005789; GO:0043295; GO:1901687; GO:0006749; GO:0004602; GO:0004364; GO:0016021; GO:0005743; GO:0005741; GO:0005739; GO:0005634; GO:0005778; GO:0070207; GO:0042493; GO:0032496; GO:0010243; GO:0044281; GO:0006805 Q8WX92 Leydig cell differentiation; apical part of cell; cellular response to lipid hydroperoxide; endoplasmic reticulum membrane; glutathione binding; glutathione derivative biosynthetic process; glutathione metabolic process; glutathione peroxidase activity; glutathione transferase activity; integral to membrane; mitochondrial inner membrane; mitochondrial outer membrane; mitochondrion; nucleus; peroxisomal membrane; protein homotrimerization; response to drug; response to lipopolysaccharide; response to organonitrogen compound; small molecule metabolic process; xenobiotic metabolic process IPR023352; IPR001129; Microsomal glutathione S-transferase 1 (Microsomal GST-1) (EC 2.5.1.18) (Microsomal GST-I) MGST1 GST12 MGST Homo sapiens (Human) TR31069_c0_g1_i1 Q3SZW1 TSSK1_BOVIN 4.00E-102 GO:0005524; GO:0001669; GO:0046872; GO:0031514; GO:0007275; GO:0004674; GO:0007286 ATP binding; acrosomal vesicle; metal ion binding; motile cilium; multicellular organismal development; protein serine/threonine kinase activity; spermatid development IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Testis-specific serine/threonine-protein kinase 1 (TSK-1) (TSK1) (TSSK-1) (Testis-specific kinase 1) (EC 2.7.11.1) TSSK1B TSSK1 Bos taurus (Bovine) TR31069_c0_g1_i2 P07949 RET_HUMAN 6.00E-09 GO:0005524; GO:0000165; GO:0061146; GO:0005509; GO:0071300; GO:0001838; GO:0010008; GO:0048484; GO:0007156; GO:0005887; GO:0097021; GO:0033619; GO:0001755; GO:0007158; GO:0042551; GO:0033630; GO:0030335; GO:2001241; GO:0072300; GO:0010976; GO:0045893; GO:0007497; GO:0004713; GO:0004872; GO:0048265; GO:0007165; GO:0004714; GO:0007169; GO:0035799; GO:0001657 Q62985 "ATP binding; MAPK cascade; Peyer's patch morphogenesis; calcium ion binding; cellular response to retinoic acid; embryonic epithelial tube formation; endosome membrane; enteric nervous system development; homophilic cell adhesion; integral to plasma membrane; lymphocyte migration into lymphoid organs; membrane protein proteolysis; neural crest cell migration; neuron cell-cell adhesion; neuron maturation; positive regulation of cell adhesion mediated by integrin; positive regulation of cell migration; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of metanephric glomerulus development; positive regulation of neuron projection development; positive regulation of transcription, DNA-dependent; posterior midgut development; protein tyrosine kinase activity; receptor activity; response to pain; signal transduction; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway; ureter maturation; ureteric bud development" IPR002126; IPR015919; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR016249; Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] RET CDHF12 CDHR16 PTC RET51 Homo sapiens (Human) TR31070_c0_g1_i1 Q05AL1 ARMC8_DANRE 0 IPR011989; IPR016024; IPR000225; Armadillo repeat-containing protein 8 armc8 zgc:153683 Danio rerio (Zebrafish) (Brachydanio rerio) TR31072_c0_g1_i1 Q5RC45 S22AO_PONAB 1.00E-13 GO:0016021; GO:0006811; GO:0022857 integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Solute carrier family 22 member 24 SLC22A24 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR31072_c1_g1_i1 A1A5C7 S22AN_HUMAN 5.00E-07 GO:0016021; GO:0006811; GO:0022857 integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; IPR005829; Solute carrier family 22 member 23 SLC22A23 C6orf85 Homo sapiens (Human) TR31072_c1_g2_i1 Q9VCA2 ORCT_DROME 2.00E-64 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR31073_c0_g2_i1 Q3UUQ7 PGAP1_MOUSE 1.00E-156 GO:0006506; GO:0009948; GO:0009880; GO:0005783; GO:0005789; GO:0021871; GO:0060322; GO:0016021; GO:0006886; GO:0015798; GO:0004518; GO:0042578; GO:0007605 GPI anchor biosynthetic process; anterior/posterior axis specification; embryonic pattern specification; endoplasmic reticulum; endoplasmic reticulum membrane; forebrain regionalization; head development; integral to membrane; intracellular protein transport; myo-inositol transport; nuclease activity; phosphoric ester hydrolase activity; sensory perception of sound IPR012908; GPI inositol-deacylase (EC 3.1.-.-) (Post-GPI attachment to proteins factor 1) Pgap1 Mus musculus (Mouse) TR31074_c0_g1_i1 Q60HG7 CGL_MACFA 2.00E-175 GO:0080146; GO:0044540; GO:0004123; GO:0019344; GO:0005737; GO:0070814; GO:0043066; GO:0043123; GO:0051092; GO:0044524; GO:0018272; GO:0030170 L-cysteine desulfhydrase activity; L-cystine L-cysteine-lyase (deaminating); cystathionine gamma-lyase activity; cysteine biosynthetic process; cytoplasm; hydrogen sulfide biosynthetic process; negative regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; protein sulfhydration; protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; pyridoxal phosphate binding IPR000277; IPR015424; IPR015421; IPR015422; Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2. Cystathionine gamma-lyase (EC 4.4.1.1) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) CTH QccE-22305 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR31082_c0_g1_i2 P20664 PRI1_MOUSE 8.00E-173 GO:0003896; GO:0046872; GO:1990077 P33609 DNA primase activity; metal ion binding; primosome complex IPR002755; IPR014052; DNA primase small subunit (EC 2.7.7.-) (DNA primase 49 kDa subunit) (p49) Prim1 Mus musculus (Mouse) TR31083_c0_g2_i2 P62876 RPAB5_MOUSE 4.00E-40 GO:0003677; GO:0005665; GO:0003899; GO:0006366; GO:0008270 "DNA binding; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase activity; transcription from RNA polymerase II promoter; zinc ion binding" IPR009057; IPR023580; IPR020789; IPR000268; "DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RNA polymerases I, II, and III subunit ABC5) (DNA-directed RNA polymerase III subunit L) (RPB10 homolog)" Polr2l Mus musculus (Mouse) TR31085_c0_g1_i2 Q6ICH7 ASPH2_HUMAN 8.00E-54 GO:0051213; GO:0016021; GO:0018193 dioxygenase activity; integral to membrane; peptidyl-amino acid modification IPR007803; IPR027443; Aspartate beta-hydroxylase domain-containing protein 2 (EC 1.14.11.-) ASPHD2 Homo sapiens (Human) TR31090_c1_g1_i1 Q641W3 NUFP1_RAT 2.00E-18 GO:0000492; GO:0022626; GO:0046872; GO:0016363; GO:0005730; GO:0005726; GO:0045944; GO:0070761; GO:0048786; GO:0030515; GO:0008023 box C/D snoRNP assembly; cytosolic ribosome; metal ion binding; nuclear matrix; nucleolus; perichromatin fibrils; positive regulation of transcription from RNA polymerase II promoter; pre-snoRNP complex; presynaptic active zone; snoRNA binding; transcription elongation factor complex IPR019496; IPR007087; IPR015880; Nuclear fragile X mental retardation-interacting protein 1 (Nuclear FMRP-interacting protein 1) Nufip1 Rattus norvegicus (Rat) TR31091_c2_g1_i1 Q9GKS9 DZAN1_MACFA 1.00E-46 GO:0008270 zinc ion binding IPR002110; IPR020683; IPR025874; IPR001876; Double zinc ribbon and ankyrin repeat-containing protein 1 DZANK1 QccE-20932 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR31092_c0_g1_i1 Q91XV4 DCXR_MESAU 2.00E-70 GO:0042732; GO:0050038; GO:0001669; GO:0005881; GO:0006006; GO:0016020; GO:0051289; GO:0005997 D-xylose metabolic process; L-xylulose reductase (NADP+) activity; acrosomal vesicle; cytoplasmic microtubule; glucose metabolic process; membrane; protein homotetramerization; xylulose metabolic process IPR002198; IPR002347; IPR016040; IPR020904; L-xylulose reductase (XR) (EC 1.1.1.10) (Dicarbonyl/L-xylulose reductase) (Sperm antigen P26h) DCXR Mesocricetus auratus (Golden hamster) TR31093_c1_g1_i1 Q1RM03 TCHP_DANRE 5.00E-70 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR026773; Trichoplein keratin filament-binding protein (Protein TCHP) tchp zgc:136634 Danio rerio (Zebrafish) (Brachydanio rerio) TR31094_c1_g1_i1 Q5T2S8 ARMC4_HUMAN 1.00E-122 IPR011989; IPR016024; IPR000225; IPR026959; IPR023231; Armadillo repeat-containing protein 4 ARMC4 Homo sapiens (Human) TR31097_c0_g1_i1 Q8R3J4 MTER1_MOUSE 1.00E-59 GO:0005739; GO:0045892; GO:0044212; GO:0006351 "mitochondrion; negative regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR003690; "mTERF domain-containing protein 1, mitochondrial (Mitochondrial transcription termination factor 3) (mTERF3)" Mterfd1 Mus musculus (Mouse) TR31098_c4_g1_i1 Q8BYH3 TRM13_MOUSE 3.00E-84 GO:0046872; GO:0008168; GO:0008033 metal ion binding; methyltransferase activity; tRNA processing IPR007871; IPR022776; IPR021721; tRNA:m(4)X modification enzyme TRM13 homolog (EC 2.1.1.225) (Coiled-coil domain-containing protein 76) Trmt13 Ccdc76 Mus musculus (Mouse) TR31099_c2_g1_i1 A0JPG1 F16B1_XENLA 7.00E-129 IPR019384; Protein FAM160B1 fam160b1 Xenopus laevis (African clawed frog) TR31099_c3_g1_i1 A8P7J8 U518_BRUMA 3.00E-07 IPR019384; UPF0518 protein Bm1_18400 Bm1_18400 Brugia malayi (Filarial nematode worm) TR311_c0_g1_i1 P33527 MRP1_HUMAN 1.00E-55 GO:0005524; GO:0042626; GO:0005794; GO:0019369; GO:0009235; GO:0005887; GO:0006691; GO:0005634; GO:0042493 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; Golgi apparatus; arachidonic acid metabolic process; cobalamin metabolic process; integral to plasma membrane; leukotriene metabolic process; nucleus; response to drug" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP MRP1 Homo sapiens (Human) TR31100_c0_g1_i1 P30568 GSTA_PLEPL 2.00E-61 GO:0005737; GO:0004364 cytoplasm; glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase A (GST-A) (EC 2.5.1.18) (GST class-theta) Pleuronectes platessa (European plaice) TR31100_c0_g1_i2 P30568 GSTA_PLEPL 4.00E-44 GO:0005737; GO:0004364 cytoplasm; glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase A (GST-A) (EC 2.5.1.18) (GST class-theta) Pleuronectes platessa (European plaice) TR31101_c0_g2_i2 Q91WL8 WWOX_MOUSE 4.00E-32 GO:0005794; GO:0016055; GO:0071560; GO:0005829; GO:0097191; GO:0072332; GO:0005902; GO:0005739; GO:0030178; GO:0005634; GO:0001649; GO:0016491; GO:0005886; GO:2001241; GO:0045944; GO:0048705 Golgi apparatus; Wnt receptor signaling pathway; cellular response to transforming growth factor beta stimulus; cytosol; extrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; microvillus; mitochondrion; negative regulation of Wnt receptor signaling pathway; nucleus; osteoblast differentiation; oxidoreductase activity; plasma membrane; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of transcription from RNA polymerase II promoter; skeletal system morphogenesis IPR002198; IPR002347; IPR016040; IPR001202; WW domain-containing oxidoreductase (EC 1.1.1.-) Wwox Wox1 Mus musculus (Mouse) TR31102_c2_g1_i1 Q8VHH7 ADCY3_MOUSE 4.00E-36 GO:0005524; GO:0007190; GO:0004016; GO:0005929; GO:0005737; GO:0016021; GO:0035556; GO:0046872; GO:0005886; GO:0007608 ATP binding; activation of adenylate cyclase activity; adenylate cyclase activity; cilium; cytoplasm; integral to membrane; intracellular signal transduction; metal ion binding; plasma membrane; sensory perception of smell IPR001054; IPR018297; "Adenylate cyclase type 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylate cyclase type III) (AC-III) (Adenylate cyclase, olfactive type) (Adenylyl cyclase 3) (AC3)" Adcy3 Mus musculus (Mouse) TR31102_c5_g1_i2 O60503 ADCY9_HUMAN 4.00E-53 GO:0005524; GO:0007202; GO:0034199; GO:0004016; GO:0007189; GO:0007193; GO:0071377; GO:0006112; GO:0007173; GO:0008543; GO:0045087; GO:0005887; GO:0035556; GO:0046872; GO:0048011; GO:0007268; GO:0055085; GO:0006833 ATP binding; activation of phospholipase C activity; activation of protein kinase A activity; adenylate cyclase activity; adenylate cyclase-activating G-protein coupled receptor signaling pathway; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; cellular response to glucagon stimulus; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; integral to plasma membrane; intracellular signal transduction; metal ion binding; neurotrophin TRK receptor signaling pathway; synaptic transmission; transmembrane transport; water transport IPR001054; IPR018297; Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (Adenylyl cyclase 9) ADCY9 KIAA0520 Homo sapiens (Human) TR31106_c1_g2_i1 P04464 CALM_WHEAT 6.00E-41 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Triticum aestivum (Wheat) TR31106_c1_g2_i2 P08052 MLR_TODPA 2.00E-16 GO:0005509; GO:0016459 calcium ion binding; myosin complex IPR011992; IPR018247; IPR002048; "Myosin regulatory light chain LC-2, mantle muscle (RLC)" Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus) TR31107_c0_g1_i2 Q15751 HERC1_HUMAN 2.00E-45 GO:0005086; GO:0005794; GO:0021702; GO:0005829; GO:0016020; GO:0010507; GO:0050885; GO:0031175; GO:0006810; GO:0004842 ARF guanyl-nucleotide exchange factor activity; Golgi apparatus; cerebellar Purkinje cell differentiation; cytosol; membrane; negative regulation of autophagy; neuromuscular process controlling balance; neuron projection development; transport; ubiquitin-protein ligase activity IPR001870; IPR008985; IPR000569; IPR009091; IPR000408; IPR018355; IPR003877; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HERC1 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 1) (p532) (p619) HERC1 Homo sapiens (Human) TR31107_c0_g1_i3 Q05086 UBE3A_HUMAN 6.00E-84 GO:0030521; GO:0007420; GO:0005737; GO:0005829; GO:0019048; GO:0005634; GO:0001541; GO:0014068; GO:0045944; GO:0060736; GO:0000502; GO:0070936; GO:0042787; GO:0035037; GO:0003713; GO:0004842 P03126; P04019; P06463; P06931; Q77E16; P04637 androgen receptor signaling pathway; brain development; cytoplasm; cytosol; modulation by virus of host morphology or physiology; nucleus; ovarian follicle development; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of transcription from RNA polymerase II promoter; prostate gland growth; proteasome complex; protein K48-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; sperm entry; transcription coactivator activity; ubiquitin-protein ligase activity IPR000569; IPR017134; Protein modification; protein ubiquitination. Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54) UBE3A E6AP EPVE6AP HPVE6A Homo sapiens (Human) TR31107_c0_g1_i4 Q5PQN1 HERC4_RAT 0 GO:0030154; GO:0005737; GO:0005829; GO:0005634; GO:0042787; GO:0007283; GO:0004842 cell differentiation; cytoplasm; cytosol; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; spermatogenesis; ubiquitin-protein ligase activity IPR000569; IPR009091; IPR000408; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HERC4 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 4) Herc4 Rattus norvegicus (Rat) TR31107_c0_g1_i5 Q5PQN1 HERC4_RAT 2.00E-118 GO:0030154; GO:0005737; GO:0005829; GO:0005634; GO:0042787; GO:0007283; GO:0004842 cell differentiation; cytoplasm; cytosol; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; spermatogenesis; ubiquitin-protein ligase activity IPR000569; IPR009091; IPR000408; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HERC4 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 4) Herc4 Rattus norvegicus (Rat) TR31108_c3_g1_i1 Q6RVV4 TIC32_PEA 4.00E-12 GO:0009706; GO:0016491; GO:0015031 chloroplast inner membrane; oxidoreductase activity; protein transport IPR002198; IPR002347; IPR016040; "Short-chain dehydrogenase TIC 32, chloroplastic (EC 1.1.1.-) (Translocon at the inner envelope membrane of chloroplasts 32) (PsTIC32)" TIC32 HP32 IEP32 Pisum sativum (Garden pea) TR31108_c5_g3_i1 Q9HBH5 RDH14_HUMAN 1.00E-08 GO:0005783; GO:0005765; GO:0005739; GO:0016491 endoplasmic reticulum; lysosomal membrane; mitochondrion; oxidoreductase activity IPR002198; IPR002347; IPR016040; Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2) RDH14 PAN2 UNQ529/PRO1072 Homo sapiens (Human) TR31108_c5_g3_i2 Q8TC12 RDH11_HUMAN 4.00E-10 GO:0052650; GO:0005789; GO:0016021; GO:0007603; GO:0042574; GO:0004745 "NADP-retinol dehydrogenase activity; endoplasmic reticulum membrane; integral to membrane; phototransduction, visible light; retinal metabolic process; retinol dehydrogenase activity" IPR002198; IPR002347; IPR016040; Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) RDH11 ARSDR1 PSDR1 CGI-82 Homo sapiens (Human) TR31111_c0_g1_i5 Q5QQ53 XYLT_DROPS 3.00E-13 GO:0042732; GO:0000139; GO:0008375; GO:0030206; GO:0050650; GO:0005789; GO:0015012; GO:0016021; GO:0030158 D-xylose metabolic process; Golgi membrane; acetylglucosaminyltransferase activity; chondroitin sulfate biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process; endoplasmic reticulum membrane; heparan sulfate proteoglycan biosynthetic process; integral to membrane; protein xylosyltransferase activity IPR003406; IPR002889; IPR024448; Glycan metabolism; chondroitin sulfate biosynthesis. Glycan metabolism; heparan sulfate biosynthesis. Xylosyltransferase oxt (EC 2.4.2.26) (Peptide O-xylosyltransferase) oxt xt GA16815 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR31111_c0_g1_i7 Q5QQ53 XYLT_DROPS 3.00E-11 GO:0042732; GO:0000139; GO:0008375; GO:0030206; GO:0050650; GO:0005789; GO:0015012; GO:0016021; GO:0030158 D-xylose metabolic process; Golgi membrane; acetylglucosaminyltransferase activity; chondroitin sulfate biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process; endoplasmic reticulum membrane; heparan sulfate proteoglycan biosynthetic process; integral to membrane; protein xylosyltransferase activity IPR003406; IPR002889; IPR024448; Glycan metabolism; chondroitin sulfate biosynthesis. Glycan metabolism; heparan sulfate biosynthesis. Xylosyltransferase oxt (EC 2.4.2.26) (Peptide O-xylosyltransferase) oxt xt GA16815 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR31114_c0_g1_i2 Q7ZVX6 UBA3_DANRE 0 GO:0005524; GO:0016881; GO:0045116; GO:0008641 ATP binding; acid-amino acid ligase activity; protein neddylation; small protein activating enzyme activity IPR014929; IPR009036; IPR016040; IPR000594; IPR023318; IPR000127; IPR019572; IPR018074; Protein modification; protein neddylation. NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) uba3 ube1c zgc:55528 Danio rerio (Zebrafish) (Brachydanio rerio) TR31119_c1_g1_i2 Q9PUT6 PTEN_XENLA 1.00E-132 GO:0030165; GO:0016605; GO:0006915; GO:0005737; GO:0046855; GO:0051717; GO:0008289; GO:0000287; GO:0030336; GO:0008285; GO:0051895; GO:0051898; GO:0046856; GO:0016314; GO:0051800; GO:0004438; GO:0043491; GO:0004722; GO:0004725; GO:0008138; GO:0010975; GO:0031647 "PDZ domain binding; PML body; apoptotic process; cytoplasm; inositol phosphate dephosphorylation; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; lipid binding; magnesium ion binding; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of focal adhesion assembly; negative regulation of protein kinase B signaling cascade; phosphatidylinositol dephosphorylation; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphatase activity; protein kinase B signaling cascade; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; regulation of neuron projection development; regulation of protein stability" IPR017361; IPR000008; IPR000340; IPR014019; IPR014020; IPR016130; "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)" pten Xenopus laevis (African clawed frog) TR31120_c3_g1_i1 Q9NU22 MDN1_HUMAN 1.00E-114 GO:0005524; GO:0016887; GO:0005730; GO:0005634; GO:0006461; GO:0051082 Q8IZL8 ATP binding; ATPase activity; nucleolus; nucleus; protein complex assembly; unfolded protein binding IPR003593; IPR011704; IPR012099; IPR027417; IPR002035; Midasin (MIDAS-containing protein) MDN1 KIAA0301 Homo sapiens (Human) TR31120_c3_g1_i2 Q9NU22 MDN1_HUMAN 1.00E-75 GO:0005524; GO:0016887; GO:0005730; GO:0005634; GO:0006461; GO:0051082 Q8IZL8 ATP binding; ATPase activity; nucleolus; nucleus; protein complex assembly; unfolded protein binding IPR003593; IPR011704; IPR012099; IPR027417; IPR002035; Midasin (MIDAS-containing protein) MDN1 KIAA0301 Homo sapiens (Human) TR31121_c0_g1_i2 Q865R1 PAOX_BOVIN 9.00E-52 GO:0052899; GO:0052904; GO:0052903; GO:0005777; GO:0052902; GO:0008215; GO:0052901 "N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; peroxisome; spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity; spermine metabolic process; spermine:oxygen oxidoreductase (spermidine-forming) activity" IPR002937; IPR016040; Amine and polyamine metabolism; spermine metabolism. Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC 1.5.3.13) (Polyamine oxidase) PAOX PAO Bos taurus (Bovine) TR31122_c0_g2_i1 Q5ZMU6 PP4R2_CHICK 8.00E-38 GO:0005634; GO:0030289; GO:0030362; GO:0010569 nucleus; protein phosphatase 4 complex; protein phosphatase type 4 regulator activity; regulation of double-strand break repair via homologous recombination IPR015267; Serine/threonine-protein phosphatase 4 regulatory subunit 2 PPP4R2 RCJMB04_1c10 Gallus gallus (Chicken) TR31124_c1_g2_i1 Q9X248 FABG_THEMA 4.00E-53 GO:0004316; GO:0051287; GO:0050661; GO:0030497 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NAD binding; NADP binding; fatty acid elongation IPR011284; IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) (Beta-Ketoacyl-acyl carrier protein reductase) (Beta-ketoacyl-ACP reductase) fabG TM_1724 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR31124_c1_g2_i2 A4FUZ6 HSDL2_BOVIN 7.00E-18 GO:0016491; GO:0005777; GO:0032934 oxidoreductase activity; peroxisome; sterol binding IPR002198; IPR002347; IPR016040; IPR003033; Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-) HSDL2 Bos taurus (Bovine) TR31124_c2_g1_i3 P35731 FABG_YEAST 6.00E-15 GO:0004316; GO:0009060; GO:0006633; GO:0006631; GO:0005739 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; aerobic respiration; fatty acid biosynthetic process; fatty acid metabolic process; mitochondrion IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) OAR1 YKL055C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR31125_c0_g2_i1 Q9Y2I8 WDR37_HUMAN 2.00E-163 IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 37 WDR37 KIAA0982 Homo sapiens (Human) TR31126_c2_g1_i2 Q9JLG8 CAN15_MOUSE 1.00E-91 GO:0004198; GO:0005622; GO:0006508; GO:0008270 calcium-dependent cysteine-type endopeptidase activity; intracellular; proteolysis; zinc ion binding IPR022684; IPR000169; IPR001300; IPR001876; Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog) Capn15 Solh Mus musculus (Mouse) TR31127_c1_g1_i1 B5XBI1 IF43A_SALSA 9.00E-47 GO:0060271; GO:0035721 cilium morphogenesis; intraflagellar retrograde transport Intraflagellar transport protein 43 homolog A ift43a Salmo salar (Atlantic salmon) TR31129_c0_g1_i1 Q3E9A0 ANTR6_ARATH 9.00E-21 GO:0031969; GO:0005315; GO:0016021; GO:0009536 chloroplast membrane; inorganic phosphate transmembrane transporter activity; integral to membrane; plastid IPR011701; IPR020846; IPR016196; "Probable anion transporter 6, chloroplastic (Phosphate transporter PHT4;5)" ANTR6 PHT4;5 At5g20380 F5O24.270 Arabidopsis thaliana (Mouse-ear cress) TR31129_c0_g4_i1 Q9MZD1 S17A5_SHEEP 5.00E-35 GO:0016021; GO:0005765; GO:0015293 integral to membrane; lysosomal membrane; symporter activity IPR011701; IPR020846; IPR016196; Sialin (Membrane glycoprotein SP55) (Sodium/sialic acid cotransporter) (Solute carrier family 17 member 5) SLC17A5 Ovis aries (Sheep) TR31130_c1_g3_i1 Q9Y2K2 SIK3_HUMAN 9.00E-170 GO:0005524; GO:0005737; GO:0000287; GO:0004674 P63104 ATP binding; cytoplasm; magnesium ion binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR015940; Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK) SIK3 KIAA0999 QSK L19 Homo sapiens (Human) TR31130_c3_g1_i3 Q6P4S6 SIK3_MOUSE 4.00E-31 GO:0005524; GO:0060351; GO:0005737; GO:0001958; GO:0035108; GO:0000287; GO:0035264; GO:0004674; GO:0032880 ATP binding; cartilage development involved in endochondral bone morphogenesis; cytoplasm; endochondral ossification; limb morphogenesis; magnesium ion binding; multicellular organism growth; protein serine/threonine kinase activity; regulation of protein localization IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR015940; Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK) Sik3 Kiaa0999 Qsk Mus musculus (Mouse) TR31130_c3_g2_i1 Q6NSM8 SIK3_DANRE 4.00E-13 GO:0005524; GO:0000287; GO:0004674 ATP binding; magnesium ion binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR015940; Serine/threonine-protein kinase SIK3 homolog (EC 2.7.11.1) (Serine/threonine-protein kinase QSK homolog) zgc:66101 Danio rerio (Zebrafish) (Brachydanio rerio) TR31131_c1_g1_i1 Q9NJ15 PCSK5_BRACL 4.00E-93 GO:0005576; GO:0016021; GO:0005886; GO:0006508; GO:0004252 extracellular region; integral to membrane; plasma membrane; proteolysis; serine-type endopeptidase activity IPR000742; IPR006212; IPR008979; IPR009030; IPR000209; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase PC6-like) (aPC6) PC6 Branchiostoma californiense (California lancelet) (Amphioxus) TR31131_c1_g1_i2 P09958 FURIN_HUMAN 1.00E-119 GO:0005796; GO:0000139; GO:0007219; GO:0008283; GO:0009986; GO:0030574; GO:0022617; GO:0016021; GO:0045121; GO:0046872; GO:0032804; GO:0032911; GO:0048406; GO:0032455; GO:0032902; GO:0048011; GO:0042277; GO:0043043; GO:0017187; GO:0005886; GO:0051044; GO:0043687; GO:0006508; GO:0009966; GO:0032940; GO:0004252; GO:0004867; GO:0006465; GO:0005802; GO:0030140; GO:0007179; GO:0019082; GO:0019068 Golgi lumen; Golgi membrane; Notch signaling pathway; cell proliferation; cell surface; collagen catabolic process; extracellular matrix disassembly; integral to membrane; membrane raft; metal ion binding; negative regulation of low-density lipoprotein particle receptor catabolic process; negative regulation of transforming growth factor beta1 production; nerve growth factor binding; nerve growth factor processing; nerve growth factor production; neurotrophin TRK receptor signaling pathway; peptide binding; peptide biosynthetic process; peptidyl-glutamic acid carboxylation; plasma membrane; positive regulation of membrane protein ectodomain proteolysis; post-translational protein modification; proteolysis; regulation of signal transduction; secretion by cell; serine-type endopeptidase activity; serine-type endopeptidase inhibitor activity; signal peptide processing; trans-Golgi network; trans-Golgi network transport vesicle; transforming growth factor beta receptor signaling pathway; viral protein processing; virion assembly IPR006212; IPR008979; IPR009030; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE) FURIN FUR PACE PCSK3 Homo sapiens (Human) TR31131_c1_g1_i3 P23188 FURIN_MOUSE 4.00E-120 GO:0008283; GO:0009986; GO:0005769; GO:0005788; GO:0005615; GO:0016021; GO:0045121; GO:0046872; GO:0032804; GO:0032911; GO:0032902; GO:0042277; GO:0043043; GO:0016486; GO:0005886; GO:0016485; GO:0006508; GO:0009966; GO:0032940; GO:0004252; GO:0004867; GO:0006465; GO:0005802; GO:0012510 cell proliferation; cell surface; early endosome; endoplasmic reticulum lumen; extracellular space; integral to membrane; membrane raft; metal ion binding; negative regulation of low-density lipoprotein particle receptor catabolic process; negative regulation of transforming growth factor beta1 production; nerve growth factor production; peptide binding; peptide biosynthetic process; peptide hormone processing; plasma membrane; protein processing; proteolysis; regulation of signal transduction; secretion by cell; serine-type endopeptidase activity; serine-type endopeptidase inhibitor activity; signal peptide processing; trans-Golgi network; trans-Golgi network transport vesicle membrane IPR006212; IPR008979; IPR009030; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE) (Prohormone convertase 3) Furin Fur Pcsk3 Mus musculus (Mouse) TR31131_c2_g1_i1 Q92824 PCSK5_HUMAN 3.00E-100 GO:0005796; GO:0009952; GO:0007267; GO:0042089; GO:0007566; GO:0048566; GO:0048706; GO:0012505; GO:0005615; GO:0007507; GO:0016021; GO:0001822; GO:0035108; GO:0032455; GO:0048011; GO:0042277; GO:0043043; GO:0006508; GO:0002001; GO:0030323; GO:0030141; GO:0004252; GO:0006465; GO:0019058 Golgi lumen; anterior/posterior pattern specification; cell-cell signaling; cytokine biosynthetic process; embryo implantation; embryonic digestive tract development; embryonic skeletal system development; endomembrane system; extracellular space; heart development; integral to membrane; kidney development; limb morphogenesis; nerve growth factor processing; neurotrophin TRK receptor signaling pathway; peptide binding; peptide biosynthetic process; proteolysis; renin secretion into blood stream; respiratory tube development; secretory granule; serine-type endopeptidase activity; signal peptide processing; viral life cycle IPR000742; IPR006212; IPR008979; IPR009030; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5) PCSK5 PC5 PC6 Homo sapiens (Human) TR31135_c3_g1_i1 Q5RA73 PDGFD_PONAB 1.00E-10 GO:0071230; GO:0005576; GO:0016020; GO:0007275; GO:0048008; GO:0051781; GO:0050730 cellular response to amino acid stimulus; extracellular region; membrane; multicellular organismal development; platelet-derived growth factor receptor signaling pathway; positive regulation of cell division; regulation of peptidyl-tyrosine phosphorylation IPR000859; IPR000072; IPR027123; "Platelet-derived growth factor D (PDGF-D) [Cleaved into: Platelet-derived growth factor D, latent form (PDGFD latent form); Platelet-derived growth factor D, receptor-binding form (PDGFD receptor-binding form)]" PDGFD Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR31135_c3_g1_i2 Q20176 NAS39_CAEEL 2.00E-13 GO:0005509; GO:0005576; GO:0004222; GO:0006508; GO:0008270 calcium ion binding; extracellular region; metalloendopeptidase activity; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Zinc metalloproteinase nas-39 (EC 3.4.24.21) (Nematode astacin 39) nas-39 F38E9.2 Caenorhabditis elegans TR31135_c4_g1_i1 P98163 YL_DROME 2.00E-08 GO:0005509; GO:0030135; GO:0016021; GO:0048477; GO:0005886; GO:0008196 calcium ion binding; coated vesicle; integral to membrane; oogenesis; plasma membrane; vitellogenin receptor activity IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023415; IPR000033; IPR002172; Putative vitellogenin receptor (Protein yolkless) (YL) yl CG1372 Drosophila melanogaster (Fruit fly) TR31135_c4_g2_i1 Q9BE74 LRP12_MACFA 8.00E-35 GO:0005905; GO:0006897; GO:0016021 coated pit; endocytosis; integral to membrane IPR000859; IPR023415; IPR002172; Low-density lipoprotein receptor-related protein 12 (LRP-12) (Fragment) LRP12 QnpA-21564 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR31135_c5_g1_i1 Q9JI18 LRP1B_MOUSE 6.00E-14 GO:0005509; GO:0016021; GO:0050750; GO:0005041; GO:0016020 Q9WVI9-1; Q80VC8; P69566 calcium ion binding; integral to membrane; low-density lipoprotein particle receptor binding; low-density lipoprotein receptor activity; membrane IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) Lrp1b Lrpdit Mus musculus (Mouse) TR31136_c0_g1_i2 A7SE07 NUBP2_NEMVE 2.00E-119 GO:0051539; GO:0005524; GO:0005737; GO:0046872 "4 iron, 4 sulfur cluster binding; ATP binding; cytoplasm; metal ion binding" IPR025669; IPR019591; IPR000808; IPR027417; Cytosolic Fe-S cluster assembly factor NUBP2 homolog v1g229988 Nematostella vectensis (Starlet sea anemone) TR31136_c0_g1_i3 A7SE07 NUBP2_NEMVE 4.00E-119 GO:0051539; GO:0005524; GO:0005737; GO:0046872 "4 iron, 4 sulfur cluster binding; ATP binding; cytoplasm; metal ion binding" IPR025669; IPR019591; IPR000808; IPR027417; Cytosolic Fe-S cluster assembly factor NUBP2 homolog v1g229988 Nematostella vectensis (Starlet sea anemone) TR31137_c4_g2_i1 A6H6E2 MMRN2_MOUSE 9.00E-07 GO:0001525; GO:0005604; GO:0005615; GO:0090051; GO:0030948 angiogenesis; basement membrane; extracellular space; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of vascular endothelial growth factor receptor signaling pathway IPR001073; IPR011489; IPR008983; Multimerin-2 Mmrn2 Mus musculus (Mouse) TR31138_c0_g3_i1 Q5DTV4 ZC12C_MOUSE 2.00E-87 GO:0004519; GO:0046872; GO:0090305 endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR021869; IPR000571; Probable ribonuclease ZC3H12C (EC 3.1.-.-) (Zinc finger CCCH domain-containing protein 12C) Zc3h12c Kiaa1726 Mus musculus (Mouse) TR31139_c1_g2_i1 A4IH75 ATGA1_XENTR 8.00E-94 GO:0006914; GO:0000407 autophagy; pre-autophagosomal structure IPR012445; Autophagy-related protein 101 atg101 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31140_c1_g1_i1 Q9D0S4 NEUL2_MOUSE 3.00E-51 GO:0030891; GO:0035556; GO:0005927; GO:0016567; GO:0045214 VCB complex; intracellular signal transduction; muscle tendon junction; protein ubiquitination; sarcomere organization IPR006573; IPR001496; Protein modification; protein ubiquitination. Neuralized-like protein 2 Neurl2 Ozz Mus musculus (Mouse) TR31141_c0_g1_i1 Q6INU7 FRRS1_XENLA 3.00E-64 GO:0016021; GO:0016491 integral to membrane; oxidoreductase activity IPR006593; IPR005018; IPR002861; Putative ferric-chelate reductase 1 (EC 1.-.-.-) frrs1 Xenopus laevis (African clawed frog) TR31142_c0_g1_i2 Q6DRC3 CU059_DANRE 3.00E-125 IPR021298; Uncharacterized protein C21orf59 homolog Danio rerio (Zebrafish) (Brachydanio rerio) TR31142_c0_g1_i4 Q6DRC3 CU059_DANRE 4.00E-125 IPR021298; Uncharacterized protein C21orf59 homolog Danio rerio (Zebrafish) (Brachydanio rerio) TR31144_c1_g1_i1 Q8N5T2 TBC19_HUMAN 3.00E-13 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; TBC1 domain family member 19 TBC1D19 Homo sapiens (Human) TR31144_c2_g1_i2 Q8N5T2 TBC19_HUMAN 0 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; TBC1 domain family member 19 TBC1D19 Homo sapiens (Human) TR31146_c0_g1_i1 Q13591 SEM5A_HUMAN 4.00E-16 GO:0007411; GO:0008046; GO:0007155; GO:0007267; GO:0016021; GO:0001569; GO:0005886 axon guidance; axon guidance receptor activity; cell adhesion; cell-cell signaling; integral to membrane; patterning of blood vessels; plasma membrane IPR016201; IPR002165; IPR001627; IPR027231; IPR000884; IPR015943; Semaphorin-5A (Semaphorin-F) (Sema F) SEMA5A SEMAF Homo sapiens (Human) TR31146_c0_g1_i2 H2A0N4 PIF_PINMG 8.00E-13 GO:0008061; GO:0006030; GO:0005576 chitin binding; chitin metabolic process; extracellular region IPR002557; IPR002035; Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] Pinctada margaritifera (Black-lipped pearl oyster) TR31148_c7_g1_i1 P62597 POTE1_CHICK 7.00E-33 GO:0000781; GO:0000784; GO:0005654; GO:0043047; GO:0007004 "chromosome, telomeric region; nuclear chromosome, telomeric region; nucleoplasm; single-stranded telomeric DNA binding; telomere maintenance via telomerase" IPR012340; IPR011564; Protection of telomeres protein 1 (cPot1) (POT1-like telomere end-binding protein) POT1 Gallus gallus (Chicken) TR31148_c7_g1_i2 Q95K48 POTE1_MACFA 1.00E-30 GO:0000781; GO:0000784; GO:0043047; GO:0007004 "chromosome, telomeric region; nuclear chromosome, telomeric region; single-stranded telomeric DNA binding; telomere maintenance via telomerase" IPR012340; IPR011564; Protection of telomeres protein 1 (POT1-like telomere end-binding protein) POT1 QtrA-10940 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR31149_c0_g1_i1 Q8NG68 TTL_HUMAN 8.00E-119 GO:0005524; GO:0006464; GO:0000226; GO:0030516; GO:0004835 ATP binding; cellular protein modification process; microtubule cytoskeleton organization; regulation of axon extension; tubulin-tyrosine ligase activity IPR004344; Tubulin--tyrosine ligase (TTL) (EC 6.3.2.25) TTL Homo sapiens (Human) TR31150_c0_g1_i1 Q8UUY8 ADRB2_ONCMY 3.00E-10 GO:0007190; GO:0007189; GO:0004941; GO:0016021; GO:0005886; GO:0006940; GO:0042312 activation of adenylate cyclase activity; adenylate cyclase-activating G-protein coupled receptor signaling pathway; beta2-adrenergic receptor activity; integral to membrane; plasma membrane; regulation of smooth muscle contraction; regulation of vasodilation IPR002233; IPR000332; IPR000276; IPR017452; Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) adrb2 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR31150_c0_g1_i2 P79148 ADRB1_CANFA 4.00E-11 GO:0005088; GO:0071880; GO:0004940; GO:0005769; GO:0016021; GO:0005886; GO:0032320; GO:0030819; GO:0043950; GO:0045823; GO:0005057 Ras guanyl-nucleotide exchange factor activity; adenylate cyclase-activating adrenergic receptor signaling pathway; beta1-adrenergic receptor activity; early endosome; integral to membrane; plasma membrane; positive regulation of Ras GTPase activity; positive regulation of cAMP biosynthetic process; positive regulation of cAMP-mediated signaling; positive regulation of heart contraction; receptor signaling protein activity IPR002233; IPR000507; IPR000276; IPR017452; Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) ADRB1 Canis familiaris (Dog) (Canis lupus familiaris) TR31150_c1_g1_i2 P29371 NK3R_HUMAN 1.00E-24 GO:0007568; GO:0042538; GO:0005887; GO:0005634; GO:0045777; GO:0010460; GO:0070474; GO:0042053; GO:0060259; GO:0042220; GO:0032355; GO:0043278; GO:0004995 Q9UHF0 aging; hyperosmotic salinity response; integral to plasma membrane; nucleus; positive regulation of blood pressure; positive regulation of heart rate; positive regulation of uterine smooth muscle contraction; regulation of dopamine metabolic process; regulation of feeding behavior; response to cocaine; response to estradiol stimulus; response to morphine; tachykinin receptor activity IPR000276; IPR017452; IPR001681; IPR001013; Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3) TACR3 NK3R TAC3R Homo sapiens (Human) TR31150_c1_g1_i3 P31355 OPSD_RANPI 3.00E-06 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR027430; IPR000732; IPR019477; Rhodopsin RHO Rana pipiens (Northern leopard frog) TR31150_c1_g1_i4 P29371 NK3R_HUMAN 5.00E-16 GO:0007568; GO:0042538; GO:0005887; GO:0005634; GO:0045777; GO:0010460; GO:0070474; GO:0042053; GO:0060259; GO:0042220; GO:0032355; GO:0043278; GO:0004995 Q9UHF0 aging; hyperosmotic salinity response; integral to plasma membrane; nucleus; positive regulation of blood pressure; positive regulation of heart rate; positive regulation of uterine smooth muscle contraction; regulation of dopamine metabolic process; regulation of feeding behavior; response to cocaine; response to estradiol stimulus; response to morphine; tachykinin receptor activity IPR000276; IPR017452; IPR001681; IPR001013; Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3) TACR3 NK3R TAC3R Homo sapiens (Human) TR31151_c0_g1_i1 O42280 WNT9A_CHICK 8.00E-124 GO:0016055; GO:0061303; GO:0072498; GO:0061072; GO:0032331; GO:0005578 Wnt receptor signaling pathway; cornea development in camera-type eye; embryonic skeletal joint development; iris morphogenesis; negative regulation of chondrocyte differentiation; proteinaceous extracellular matrix IPR005817; IPR026535; IPR013303; IPR018161; Protein Wnt-9a (Wnt-14) WNT9A WNT14 Gallus gallus (Chicken) TR31153_c5_g2_i1 Q66KE3 CPSF4_XENTR 7.00E-15 GO:0003723; GO:0005847; GO:0006397; GO:0008270 RNA binding; mRNA cleavage and polyadenylation specificity factor complex; mRNA processing; zinc ion binding IPR000571; IPR001878; Cleavage and polyadenylation specificity factor subunit 4 cpsf4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31153_c5_g2_i2 Q3ED78 C3H7_ARATH 3.00E-42 GO:0003677; GO:0003723; GO:0046872; GO:0004518; GO:0090305 DNA binding; RNA binding; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis IPR000571; Zinc finger CCCH domain-containing protein 7 (AtC3H7) (EC 3.1.-.-) (AtSmicl) At1g21570 F24J8.21 Arabidopsis thaliana (Mouse-ear cress) TR31153_c5_g2_i3 Q8CHP0 ZC3H3_MOUSE 2.00E-48 GO:0070412; GO:0005847; GO:0006378; GO:0046872; GO:0016973; GO:0032927; GO:0010793 R-SMAD binding; mRNA cleavage and polyadenylation specificity factor complex; mRNA polyadenylation; metal ion binding; poly(A)+ mRNA export from nucleus; positive regulation of activin receptor signaling pathway; regulation of mRNA export from nucleus IPR000571; Zinc finger CCCH domain-containing protein 3 Zc3h3 Kiaa0150 Zc3hdc3 Zfp623 Mus musculus (Mouse) TR31154_c1_g1_i1 P56652 ITIH3_BOVIN 3.00E-15 GO:0005576; GO:0030212; GO:0004867 extracellular region; hyaluronan metabolic process; serine-type endopeptidase inhibitor activity IPR010600; IPR013694; IPR002035; Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) ITIH3 Bos taurus (Bovine) TR31156_c0_g1_i1 P09648 CATL1_CHICK 9.00E-101 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; Cathepsin L1 (EC 3.4.22.15) (Cathepsin L) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain] (Fragments) CTSL CTSL1 Gallus gallus (Chicken) TR31156_c0_g1_i2 Q26636 CATL_SARPE 1.00E-123 GO:0030154; GO:0008234; GO:0005764; GO:0007275; GO:0006508 cell differentiation; cysteine-type peptidase activity; lysosome; multicellular organismal development; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) TR31158_c0_g1_i2 Q0APM5 KYNB_MARMM 2.00E-06 GO:0043420; GO:0004061; GO:0004328; GO:0019441 anthranilate metabolic process; arylformamidase activity; formamidase activity; tryptophan catabolic process to kynurenine IPR007325; IPR017484; Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. Kynurenine formamidase (KFA) (KFase) (EC 3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF) kynB Mmar10_1470 Maricaulis maris (strain MCS10) TR31158_c0_g1_i4 Q0APM5 KYNB_MARMM 2.00E-06 GO:0043420; GO:0004061; GO:0004328; GO:0019441 anthranilate metabolic process; arylformamidase activity; formamidase activity; tryptophan catabolic process to kynurenine IPR007325; IPR017484; Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. Kynurenine formamidase (KFA) (KFase) (EC 3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF) kynB Mmar10_1470 Maricaulis maris (strain MCS10) TR31159_c1_g2_i1 Q9CYR6 AGM1_MOUSE 0 GO:0006048; GO:0005975; GO:0005829; GO:0009790; GO:0019255; GO:0030097; GO:0000287; GO:0004610; GO:0004614; GO:0007283 UDP-N-acetylglucosamine biosynthetic process; carbohydrate metabolic process; cytosol; embryo development; glucose 1-phosphate metabolic process; hemopoiesis; magnesium ion binding; phosphoacetylglucosamine mutase activity; phosphoglucomutase activity; spermatogenesis IPR005844; IPR016055; IPR005845; IPR005843; IPR016066; IPR016657; Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2. Phosphoacetylglucosamine mutase (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) (Phosphoglucomutase-3) (PGM 3) Pgm3 Agm1 Pgm-3 Mus musculus (Mouse) TR31159_c2_g2_i2 Q8TDN4 CABL1_HUMAN 1.00E-49 GO:0007596; GO:0007049; GO:0051301; GO:0016538; GO:0005829; GO:0007399; GO:0005634; GO:0051726; GO:0051302 Q00535; Q9H3D4-1 blood coagulation; cell cycle; cell division; cyclin-dependent protein serine/threonine kinase regulator activity; cytosol; nervous system development; nucleus; regulation of cell cycle; regulation of cell division IPR012388; IPR013763; IPR006671; CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) CABLES1 CABLES Homo sapiens (Human) TR31161_c2_g1_i1 O43614 OX2R_HUMAN 1.00E-08 GO:0022410; GO:0007631; GO:0005887; GO:0008188; GO:0016499; GO:0017046; GO:0007200 circadian sleep/wake cycle process; feeding behavior; integral to plasma membrane; neuropeptide receptor activity; orexin receptor activity; peptide hormone binding; phospholipase C-activating G-protein coupled receptor signaling pathway IPR000276; IPR017452; IPR000204; IPR004060; Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) HCRTR2 Homo sapiens (Human) TR31162_c1_g1_i3 Q9Y5K1 SPO11_HUMAN 3.00E-65 GO:0005524; GO:0003677; GO:0000781; GO:0007292; GO:0016787; GO:0007141; GO:0005634; GO:0001541; GO:0034502; GO:0007131; GO:0007286; GO:0007283; GO:0007129 "ATP binding; DNA binding; chromosome, telomeric region; female gamete generation; hydrolase activity; male meiosis I; nucleus; ovarian follicle development; protein localization to chromosome; reciprocal meiotic recombination; spermatid development; spermatogenesis; synapsis" IPR004084; IPR013048; IPR002815; IPR013049; IPR011991; Meiotic recombination protein SPO11 (Cancer/testis antigen 35) (CT35) SPO11 Homo sapiens (Human) TR31163_c2_g1_i2 Q08DB5 STX5_BOVIN 1.00E-114 GO:0000139; GO:0033116; GO:0016021; GO:0006886; GO:0042147 "Golgi membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; intracellular protein transport; retrograde transport, endosome to Golgi" IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin-5 STX5 Bos taurus (Bovine) TR31167_c0_g1_i1 B7Q290 YC029_IXOSC 1.00E-09 Uncharacterized protein ISCW010018 ISCW010018 Ixodes scapularis (Black-legged tick) (Deer tick) TR31171_c0_g1_i1 Q8WWX0 ASB5_HUMAN 9.00E-15 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 5 (ASB-5) ASB5 Homo sapiens (Human) TR31171_c0_g1_i3 Q96DX5 ASB9_HUMAN 1.00E-13 GO:0005737; GO:0035556; GO:0005739; GO:0005634; GO:0045732; GO:0016567 P12277; Q9NWT6 cytoplasm; intracellular signal transduction; mitochondrion; nucleus; positive regulation of protein catabolic process; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 9 (ASB-9) ASB9 Homo sapiens (Human) TR31171_c1_g1_i1 P16157 ANK1_HUMAN 5.00E-19 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR31171_c1_g1_i10 Q01317 NUC2_NEUCR 1.00E-06 GO:0004190; GO:0006071; GO:0008889; GO:0006629; GO:0006508 aspartic-type endopeptidase activity; glycerol metabolic process; glycerophosphodiester phosphodiesterase activity; lipid metabolic process; proteolysis IPR002110; IPR020683; IPR004129; IPR001995; IPR017946; IPR004331; Ankyrin repeat protein nuc-2 nuc-2 B23G1.010 NCU01847 NCU11426 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR31171_c1_g1_i11 Q9ERK0 RIPK4_MOUSE 2.00E-18 GO:0005524; GO:0005737; GO:0016020; GO:0004674 Q6Q0C0 ATP binding; cytoplasm; membrane; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR017441; IPR008271; Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-associated protein kinase) (PKC-regulated protein kinase) Ripk4 Ankrd3 Pkk Mus musculus (Mouse) TR31171_c1_g1_i5 Q04721 NOTC2_HUMAN 2.00E-15 GO:0000139; GO:0007220; GO:0061314; GO:0006915; GO:0060413; GO:0046849; GO:0005509; GO:0007050; GO:0001709; GO:0016049; GO:0009986; GO:0005789; GO:0005576; GO:0030097; GO:0005887; GO:0043066; GO:0008285; GO:0007399; GO:0005654; GO:0046579; GO:0003184; GO:0004872; GO:0006355; GO:0019827; GO:0006367 "Golgi membrane; Notch receptor processing; Notch signaling involved in heart development; apoptotic process; atrial septum morphogenesis; bone remodeling; calcium ion binding; cell cycle arrest; cell fate determination; cell growth; cell surface; endoplasmic reticulum membrane; extracellular region; hemopoiesis; integral to plasma membrane; negative regulation of apoptotic process; negative regulation of cell proliferation; nervous system development; nucleoplasm; positive regulation of Ras protein signal transduction; pulmonary valve morphogenesis; receptor activity; regulation of transcription, DNA-dependent; stem cell maintenance; transcription initiation from RNA polymerase II promoter" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022336; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation; Notch 2 intracellular domain] NOTCH2 Homo sapiens (Human) TR31171_c1_g1_i6 Q8Q0U0 Y045_METMA 8.00E-21 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR31171_c1_g1_i7 Q5UPG5 YL093_MIMIV 6.00E-17 IPR002110; IPR020683; Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) TR31171_c1_g1_i8 Q9W0T5 PYX_DROME 3.00E-16 GO:0005262; GO:0034703; GO:0048060; GO:0051290; GO:0009408 calcium channel activity; cation channel complex; negative gravitaxis; protein heterotetramerization; response to heat IPR002110; IPR020683; IPR005821; Transient receptor potential channel pyrexia pyx CG17142 Drosophila melanogaster (Fruit fly) TR31175_c0_g1_i1 Q9NVS2 RT18A_HUMAN 1.00E-20 GO:0005763; GO:0003735; GO:0006412 mitochondrial small ribosomal subunit; structural constituent of ribosome; translation IPR001648; "28S ribosomal protein S18a, mitochondrial (MRP-S18-a) (Mrps18a) (S18mt-a) (28S ribosomal protein S18-3, mitochondrial) (MRP-S18-3)" MRPS18A Homo sapiens (Human) TR31176_c0_g1_i1 A5PK00 VPS36_BOVIN 1.00E-161 GO:0005768; GO:0005770; GO:0016020; GO:0005634; GO:0032266; GO:0015031; GO:0006355; GO:0006351 "endosome; late endosome; membrane; nucleus; phosphatidylinositol-3-phosphate binding; protein transport; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007286; IPR021648; IPR011991; Vacuolar protein-sorting-associated protein 36 (ESCRT-II complex subunit VPS36) VPS36 Bos taurus (Bovine) TR31180_c1_g1_i1 Q7Z6J0 SH3R1_HUMAN 5.00E-29 GO:0005794; GO:0005829; GO:0030027; GO:0016874; GO:0043066; GO:0043154; GO:2001237; GO:0048471; GO:0016567; GO:0046328; GO:0008270 P63000; O43255 Golgi apparatus; cytosol; lamellipodium; ligase activity; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; perinuclear region of cytoplasm; protein ubiquitination; regulation of JNK cascade; zinc ion binding IPR000108; IPR001452; IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase SH3RF1 (EC 6.3.2.-) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2) SH3RF1 KIAA1494 POSH RNF142 SH3MD2 Homo sapiens (Human) TR31180_c1_g1_i4 Q69ZI1 SH3R1_MOUSE 3.00E-30 GO:0005794; GO:0030027; GO:0016874; GO:0048471; GO:0016567; GO:0008270 Q9Z2F7; Q8IUQ4 Golgi apparatus; lamellipodium; ligase activity; perinuclear region of cytoplasm; protein ubiquitination; zinc ion binding IPR000108; IPR001452; IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase SH3RF1 (EC 6.3.2.-) (Plenty of SH3s) (Protein POSH) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2) Sh3rf1 Kiaa1494 Posh Sh3md2 Mus musculus (Mouse) TR31181_c2_g2_i1 Q8R2E9 ERO1B_MOUSE 1.00E-156 GO:0005789; GO:0016671; GO:0003756; GO:0006457 "endoplasmic reticulum membrane; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; protein disulfide isomerase activity; protein folding" IPR007266; ERO1-like protein beta (ERO1-L-beta) (EC 1.8.4.-) (Endoplasmic oxidoreductin-1-like protein B) (Oxidoreductin-1-L-beta) Ero1lb Mus musculus (Mouse) TR31182_c0_g1_i2 Q9Z2Y1 TIM_RAT 2.00E-14 GO:0001658; GO:0051301; GO:0007623; GO:0001822; GO:0007067; GO:0045892; GO:0005634; GO:0042753; GO:0006974; GO:0006351 "branching involved in ureteric bud morphogenesis; cell division; circadian rhythm; kidney development; mitosis; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of circadian rhythm; response to DNA damage stimulus; transcription, DNA-dependent" IPR006906; IPR007725; Protein timeless homolog (rTIM) (Timeless-like protein) (rTLP) Timeless Rattus norvegicus (Rat) TR31183_c0_g2_i1 Q24733 ACT_DICVI 3.00E-14 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; Actin (Fragment) Dictyocaulus viviparus (Bovine lungworm) TR31183_c1_g1_i1 P69003 ACT1_HELTB 6.00E-104 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin CyI, cytoplasmic" Heliocidaris tuberculata (Sea urchin) TR31183_c1_g1_i2 P85911 ACT1_PSEMZ 5.00E-22 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; Actin-1 (Fragment) Pseudotsuga menziesii (Douglas-fir) (Abies menziesii) TR31183_c2_g1_i1 Q4P2E8 ARP4_USTMA 6.00E-16 GO:0006281; GO:0016568; GO:0005634; GO:0006355; GO:0006351 "DNA repair; chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR004000; IPR004001; Actin-related protein 4 (Actin-like protein ARP4) (Actin-like protein 4) ARP4 UM05715 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR31183_c2_g1_i2 P18602 ACT3_ARTSX 6.00E-90 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin, clone 302 (Fragment)" Artemia sp. (Brine shrimp) TR31185_c0_g1_i1 A5I348 MSRA_CLOBH 6.00E-22 GO:0006464; GO:0008113 cellular protein modification process; peptide-methionine (S)-S-oxide reductase activity IPR002569; Peptide methionine sulfoxide reductase MsrA (Protein-methionine-S-oxide reductase) (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) msrA CBO1923 CLC_1868 Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) TR31185_c0_g1_i2 A8M3K6 MSRA_SALAI 4.00E-22 GO:0006464; GO:0008113 cellular protein modification process; peptide-methionine (S)-S-oxide reductase activity IPR002569; Peptide methionine sulfoxide reductase MsrA (Protein-methionine-S-oxide reductase) (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) msrA Sare_0861 Salinispora arenicola (strain CNS-205) TR31185_c0_g1_i3 P08761 MSRA_DROME 3.00E-42 GO:0034599; GO:0008340; GO:0048812; GO:0008113; GO:0035071; GO:0000096 cellular response to oxidative stress; determination of adult lifespan; neuron projection morphogenesis; peptide-methionine (S)-S-oxide reductase activity; salivary gland cell autophagic cell death; sulfur amino acid metabolic process IPR002569; Peptide methionine sulfoxide reductase (EC 1.8.4.11) (Ecdysone-induced protein 28/29 kDa) (Methionine-S-sulfoxide reductase) (Peptide-methionine (S)-S-oxide reductase) Eip71CD Eip28/29 MsrA CG7266 Drosophila melanogaster (Fruit fly) TR31187_c0_g1_i1 P57110 ATS8_MOUSE 3.00E-11 GO:0008201; GO:0004222; GO:0005578; GO:0006508; GO:0008270 heparin binding; metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR013277; IPR001590; IPR013273; IPR002870; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAM-TS 8) (ADAM-TS8) (ADAMTS-8) (EC 3.4.24.-) (METH-2) Adamts8 Mus musculus (Mouse) TR31187_c0_g1_i2 P35440 TSP2_CHICK 3.00E-26 GO:0005604; GO:0005509; GO:0007155; GO:0008201; GO:0016525 basement membrane; calcium ion binding; cell adhesion; heparin binding; negative regulation of angiogenesis IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR024731; IPR001791; IPR000884; IPR015455; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-2 THBS2 TSP2 Gallus gallus (Chicken) TR31189_c1_g1_i1 Q9C8Y1 CML23_ARATH 2.00E-14 GO:0005509; GO:0009909; GO:0080164 calcium ion binding; regulation of flower development; regulation of nitric oxide metabolic process IPR011992; IPR018247; IPR002048; Probable calcium-binding protein CML23 (Calmodulin-like protein 23) CML23 At1g66400 T27F4.15 Arabidopsis thaliana (Mouse-ear cress) TR31189_c1_g1_i2 O82040 POLC7_PHLPR 8.00E-11 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Polcalcin Phl p 7 (Calcium-binding pollen allergen Phl p 7) (P7) (allergen Phl p 7) Phleum pratense (Common timothy) TR31189_c1_g1_i3 P14533 CABO_LOLPE 2.00E-33 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Squidulin (Optic lobe calcium-binding protein) (SCABP) Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR3119_c0_g1_i1 Q5ZI11 LRC45_CHICK 2.00E-22 Leucine-rich repeat-containing protein 45 LRRC45 RCJMB04_31i7 Gallus gallus (Chicken) TR31192_c0_g1_i1 Q8VHV8 SELS_RAT 1.00E-07 GO:0005881; GO:0030176; GO:0006886; GO:0008430 cytoplasmic microtubule; integral to endoplasmic reticulum membrane; intracellular protein transport; selenium binding IPR009703; Selenoprotein S (SelS) (Sg2) (VCP-interacting membrane protein) Vimp Sels Rattus norvegicus (Rat) TR31193_c0_g1_i1 P26153 ACHB4_CHICK 3.00E-55 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit beta-4 (Neuronal acetylcholine receptor non-alpha-3 chain) (N-alpha 3) (Fragment) CHRNB4 Gallus gallus (Chicken) TR31193_c0_g2_i1 P09478 ACH1_DROME 5.00E-71 GO:0004889; GO:0005892; GO:0030054; GO:0045211; GO:0017085; GO:0007271 "acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; postsynaptic membrane; response to insecticide; synaptic transmission, cholinergic" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha-like 1 nAcRalpha-96Aa Acr96Aa AcrB als CG5610 Drosophila melanogaster (Fruit fly) TR31193_c0_g2_i2 P09478 ACH1_DROME 8.00E-75 GO:0004889; GO:0005892; GO:0030054; GO:0045211; GO:0017085; GO:0007271 "acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; postsynaptic membrane; response to insecticide; synaptic transmission, cholinergic" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha-like 1 nAcRalpha-96Aa Acr96Aa AcrB als CG5610 Drosophila melanogaster (Fruit fly) TR31194_c1_g1_i1 Q9ULJ7 ANR50_HUMAN 6.00E-10 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) TR31194_c1_g1_i2 P16157 ANK1_HUMAN 2.00E-08 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR31194_c1_g1_i3 Q8C8R3 ANK2_MOUSE 1.00E-07 GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005887; GO:0014704; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086015; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307 "M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; integral to plasma membrane; intercalated disc; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of SA node cell action potential; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Brain ankyrin) Ank2 Mus musculus (Mouse) TR31197_c1_g2_i1 P48380 RFX3_HUMAN 0 GO:0003705; GO:0048469; GO:0060285; GO:0042384; GO:0031018; GO:0060287; GO:0045892; GO:0000790; GO:0045944; GO:2000078; GO:0050796; GO:0005667; GO:0044212; GO:0072560 "RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; cell maturation; ciliary cell motility; cilium assembly; endocrine pancreas development; epithelial cilium movement involved in determination of left/right asymmetry; negative regulation of transcription, DNA-dependent; nuclear chromatin; positive regulation of transcription from RNA polymerase II promoter; positive regulation of type B pancreatic cell development; regulation of insulin secretion; transcription factor complex; transcription regulatory region DNA binding; type B pancreatic cell maturation" IPR003150; IPR007668; IPR011991; Transcription factor RFX3 (Regulatory factor X 3) RFX3 Homo sapiens (Human) TR31197_c1_g2_i10 Q5EAP5 RFX2_DANRE 0 GO:0003677; GO:0005634; GO:0006355; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003150; IPR007668; IPR011991; DNA-binding protein RFX2 (Regulatory factor X 2) rfx2 zgc:91808 Danio rerio (Zebrafish) (Brachydanio rerio) TR31197_c1_g2_i12 P48380 RFX3_HUMAN 0 GO:0003705; GO:0048469; GO:0060285; GO:0042384; GO:0031018; GO:0060287; GO:0045892; GO:0000790; GO:0045944; GO:2000078; GO:0050796; GO:0005667; GO:0044212; GO:0072560 "RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; cell maturation; ciliary cell motility; cilium assembly; endocrine pancreas development; epithelial cilium movement involved in determination of left/right asymmetry; negative regulation of transcription, DNA-dependent; nuclear chromatin; positive regulation of transcription from RNA polymerase II promoter; positive regulation of type B pancreatic cell development; regulation of insulin secretion; transcription factor complex; transcription regulatory region DNA binding; type B pancreatic cell maturation" IPR003150; IPR007668; IPR011991; Transcription factor RFX3 (Regulatory factor X 3) RFX3 Homo sapiens (Human) TR31197_c1_g2_i3 P48377 RFX1_MOUSE 0 GO:0003677; GO:0005634; GO:0006355; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003150; IPR007668; IPR011991; MHC class II regulatory factor RFX1 (Regulatory factor X 1) (Transcription factor RFX1) Rfx1 Mus musculus (Mouse) TR31197_c1_g2_i4 P48380 RFX3_HUMAN 0 GO:0003705; GO:0048469; GO:0060285; GO:0042384; GO:0031018; GO:0060287; GO:0045892; GO:0000790; GO:0045944; GO:2000078; GO:0050796; GO:0005667; GO:0044212; GO:0072560 "RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; cell maturation; ciliary cell motility; cilium assembly; endocrine pancreas development; epithelial cilium movement involved in determination of left/right asymmetry; negative regulation of transcription, DNA-dependent; nuclear chromatin; positive regulation of transcription from RNA polymerase II promoter; positive regulation of type B pancreatic cell development; regulation of insulin secretion; transcription factor complex; transcription regulatory region DNA binding; type B pancreatic cell maturation" IPR003150; IPR007668; IPR011991; Transcription factor RFX3 (Regulatory factor X 3) RFX3 Homo sapiens (Human) TR31197_c1_g2_i8 P48383 SAK1_SCHPO 1.00E-07 GO:0003677; GO:0001078; GO:0005737; GO:0000790; GO:0031536 DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; cytoplasm; nuclear chromatin; positive regulation of exit from mitosis IPR003150; IPR011991; Protein sak1 sak1 SPAC3G9.14 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR31200_c2_g1_i1 Q7SZ59 RASLC_DANRE 3.00E-56 GO:0005525; GO:0003924; GO:0016020; GO:0007264 GTP binding; GTPase activity; membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; Ras-like protein family member 12 (RAS-like protein Ris) RASL12 zgc:63633 Danio rerio (Zebrafish) (Brachydanio rerio) TR31202_c0_g3_i2 Q5M819 SERB_RAT 3.00E-96 GO:0006564; GO:0005509; GO:0005737; GO:0000287; GO:0043005; GO:0004647; GO:0009612; GO:0031667; GO:0033574 L-serine biosynthetic process; calcium ion binding; cytoplasm; magnesium ion binding; neuron projection; phosphoserine phosphatase activity; response to mechanical stimulus; response to nutrient levels; response to testosterone stimulus IPR023214; IPR006383; IPR023190; IPR004469; Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3. Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (O-phosphoserine phosphohydrolase) Psph Rattus norvegicus (Rat) TR31206_c1_g2_i2 O50655 XERD_SELRU 3.00E-16 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR31206_c1_g2_i3 Q89703 POL_CSVMV 4.00E-07 GO:0003677; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0046872; GO:0090305; GO:0006508; GO:0004523 DNA binding; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity IPR000588; IPR000477; Putative enzymatic polyprotein [Includes: Protease (PR) (EC 3.4.23.-); Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4)] ORF 3 Cassava vein mosaic virus (CsVMV) TR31206_c1_g2_i6 Q89703 POL_CSVMV 3.00E-07 GO:0003677; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0046872; GO:0090305; GO:0006508; GO:0004523 DNA binding; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity IPR000588; IPR000477; Putative enzymatic polyprotein [Includes: Protease (PR) (EC 3.4.23.-); Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4)] ORF 3 Cassava vein mosaic virus (CsVMV) TR31206_c1_g2_i7 O50655 XERD_SELRU 2.00E-16 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR31207_c0_g1_i1 P34277 GSTO2_CAEEL 4.00E-41 GO:0005737; GO:0045174; GO:0004364; GO:0050610 cytoplasm; glutathione dehydrogenase (ascorbate) activity; glutathione transferase activity; methylarsonate reductase activity IPR010987; IPR004045; IPR004046; IPR005442; IPR012336; Probable glutathione transferase omega-2 (EC 2.5.1.18) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) gsto-2 C02D5.3 Caenorhabditis elegans TR31207_c0_g1_i2 P78417 GSTO1_HUMAN 4.00E-56 GO:0019852; GO:0071243; GO:0005829; GO:0045174; GO:1901687; GO:0004364; GO:0050610; GO:0060315; GO:0060316; GO:0014810; GO:0010881; GO:0042178 L-ascorbic acid metabolic process; cellular response to arsenic-containing substance; cytosol; glutathione dehydrogenase (ascorbate) activity; glutathione derivative biosynthetic process; glutathione transferase activity; methylarsonate reductase activity; negative regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; xenobiotic catabolic process IPR010987; IPR004045; IPR004046; IPR005442; IPR012336; Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R) GSTO1 GSTTLP28 Homo sapiens (Human) TR31207_c0_g1_i3 P42760 GSTF6_ARATH 4.00E-06 GO:2001147; GO:0005618; GO:0050897; GO:0005507; GO:0005829; GO:0042742; GO:0043295; GO:0004364; GO:0005739; GO:0009506; GO:2001227; GO:0046686; GO:0006979; GO:0009651; GO:0009636; GO:0009414; GO:0009407; GO:0005773 camalexin binding; cell wall; cobalt ion binding; copper ion binding; cytosol; defense response to bacterium; glutathione binding; glutathione transferase activity; mitochondrion; plasmodesma; quercitrin binding; response to cadmium ion; response to oxidative stress; response to salt stress; response to toxic substance; response to water deprivation; toxin catabolic process; vacuole IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase F6 (AtGSTF6) (EC 2.5.1.18) (AtGSTF3) (GST class-phi member 6) (Glutathione S-transferase 1) (AtGST1) (Protein EARLY RESPONSE TO DEHYDRATION 11) GSTF6 ERD11 GST1 GSTF3 At1g02930 F22D16.7 Arabidopsis thaliana (Mouse-ear cress) TR31208_c0_g1_i2 Q9DBW3 GTL3B_MOUSE 4.00E-17 IPR016181; Protein GTLF3B (Gene trap locus protein F3-2) (Gene trap locus protein F3b) Gtlf3b Gm16515 Mus musculus (Mouse) TR31208_c0_g1_i3 Q5D014 GTL3B_DANRE 5.00E-18 IPR016181; Protein GTLF3B gtlf3b zgc:110779 Danio rerio (Zebrafish) (Brachydanio rerio) TR31209_c0_g2_i2 P20483 MPIP_DROME 3.00E-69 GO:0000086; GO:0007030; GO:0051301; GO:0008283; GO:0007099; GO:0005694; GO:0007369; GO:0046331; GO:0007498; GO:0007067; GO:0045792; GO:0045930; GO:0005634; GO:0007424; GO:0007422; GO:0008284; GO:0045977; GO:0004725; GO:0008138; GO:0060305 "G2/M transition of mitotic cell cycle; Golgi organization; cell division; cell proliferation; centriole replication; chromosome; gastrulation; lateral inhibition; mesoderm development; mitosis; negative regulation of cell size; negative regulation of mitotic cell cycle; nucleus; open tracheal system development; peripheral nervous system development; positive regulation of cell proliferation; positive regulation of mitotic cell cycle, embryonic; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; regulation of cell diameter" IPR000751; IPR001763; M-phase inducer phosphatase (EC 3.1.3.48) (Cdc25-like protein) (Protein string) stg cdc25 CG1395 Drosophila melanogaster (Fruit fly) TR31211_c1_g1_i1 Q3SYV9 ARHL2_BOVIN 8.00E-82 GO:0046872; GO:0005759; GO:0005634; GO:0004649 metal ion binding; mitochondrial matrix; nucleus; poly(ADP-ribose) glycohydrolase activity IPR005502; Poly(ADP-ribose) glycohydrolase ARH3 (EC 3.2.1.143) (ADP-ribosylhydrolase 3) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ADPRHL2 ARH3 Bos taurus (Bovine) TR31211_c1_g2_i1 Q6ZQT0 YD023_HUMAN 3.00E-11 Putative uncharacterized protein FLJ45035 Homo sapiens (Human) TR31213_c6_g1_i1 Q9QUN7 TLR2_MOUSE 1.00E-26 GO:0002755; GO:0035354; GO:0035355; GO:0002752; GO:0071221; GO:0071223; GO:0071224; GO:0042892; GO:0050830; GO:0042498; GO:0009897; GO:0052063; GO:0006954; GO:0045087; GO:0016021; GO:0070891; GO:0044130; GO:0032695; GO:0032700; GO:0030670; GO:0032722; GO:0050715; GO:0050729; GO:0032728; GO:0032735; GO:0032741; GO:0032755; GO:0002687; GO:0060907; GO:0045429; GO:0051770; GO:0045944; GO:0042535; GO:0032760; GO:0046982; GO:0002238; GO:0034134; GO:0004888; GO:0042497 MyD88-dependent toll-like receptor signaling pathway; Toll-like receptor 1-Toll-like receptor 2 protein complex; Toll-like receptor 2-Toll-like receptor 6 protein complex; cell surface pattern recognition receptor signaling pathway; cellular response to bacterial lipopeptide; cellular response to lipoteichoic acid; cellular response to peptidoglycan; chloramphenicol transport; defense response to Gram-positive bacterium; diacyl lipopeptide binding; external side of plasma membrane; induction by symbiont of defense-related host nitric oxide production; inflammatory response; innate immune response; integral to membrane; lipoteichoic acid binding; negative regulation of growth of symbiont in host; negative regulation of interleukin-12 production; negative regulation of interleukin-17 production; phagocytic vesicle membrane; positive regulation of chemokine production; positive regulation of cytokine secretion; positive regulation of inflammatory response; positive regulation of interferon-beta production; positive regulation of interleukin-12 production; positive regulation of interleukin-18 production; positive regulation of interleukin-6 production; positive regulation of leukocyte migration; positive regulation of macrophage cytokine production; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of tumor necrosis factor production; protein heterodimerization activity; response to molecule of fungal origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity; triacyl lipopeptide binding IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) Tlr2 Mus musculus (Mouse) TR31213_c6_g1_i2 Q5I2M4 TLR9_SHEEP 4.00E-08 GO:0002755; GO:0032009; GO:0005783; GO:0005789; GO:0005768; GO:0006954; GO:0045087; GO:0016021; GO:0005764; GO:0050729; GO:0045356; GO:0045359; GO:0045078; GO:0050707; GO:0002237; GO:0035197; GO:0034162; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; early phagosome; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; inflammatory response; innate immune response; integral to membrane; lysosome; positive regulation of inflammatory response; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-gamma biosynthetic process; regulation of cytokine secretion; response to molecule of bacterial origin; siRNA binding; toll-like receptor 9 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR000157; IPR027181; Toll-like receptor 9 (CD antigen CD289) TLR9 Ovis aries (Sheep) TR31215_c0_g1_i1 Q4R708 NAA35_MACFA 0 GO:0005737; GO:0048659 cytoplasm; smooth muscle cell proliferation IPR007244; "N-alpha-acetyltransferase 35, NatC auxiliary subunit (Protein MAK10 homolog)" NAA35 MAK10 QtsA-16666 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR31216_c8_g1_i1 Q5ZKD7 MOV10_CHICK 1.00E-117 GO:0005524; GO:0003723; GO:0000932; GO:0004386; GO:0035279 ATP binding; RNA binding; cytoplasmic mRNA processing body; helicase activity; mRNA cleavage involved in gene silencing by miRNA IPR027417; Putative helicase MOV-10 (EC 3.6.4.13) MOV10 RCJMB04_11i10 Gallus gallus (Chicken) TR31216_c8_g1_i2 Q1LXK4 M10B1_DANRE 3.00E-126 GO:0005524; GO:0003723; GO:0000932; GO:0004386; GO:0035279 ATP binding; RNA binding; cytoplasmic mRNA processing body; helicase activity; mRNA cleavage involved in gene silencing by miRNA IPR003593; IPR027417; Putative helicase mov-10-B.1 (EC 3.6.4.13) mov10b.1 si:dkeyp-38g6.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR31217_c0_g1_i1 Q16982 NECX_APLCA 2.00E-28 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Neurocalcin Aplysia californica (California sea hare) TR31219_c0_g1_i1 Q8W471 AAE15_ARATH 8.00E-29 GO:0009941; GO:0030497; GO:0008922 chloroplast envelope; fatty acid elongation; long-chain fatty acid [acyl-carrier-protein] ligase activity IPR020845; IPR000873; "Long-chain-fatty-acid--[acyl-carrier-protein] ligase AEE15, chloroplastic (EC 6.2.1.20) (Acyl-[acyl-carrier-protein] synthetase) (Acyl-activating enzyme 15)" AAE15 At4g14070 dl3075c FCAALL.81 Arabidopsis thaliana (Mouse-ear cress) TR31219_c0_g1_i2 O95573 ACSL3_HUMAN 0 GO:0005524; GO:0005794; GO:0007420; GO:0005783; GO:0005789; GO:0006633; GO:0016021; GO:0005811; GO:0044539; GO:0004467; GO:0005741; GO:0048471; GO:0005778; GO:0042998; GO:2001247; GO:0051047; GO:0007584; GO:0014070; GO:0034379 ATP binding; Golgi apparatus; brain development; endoplasmic reticulum; endoplasmic reticulum membrane; fatty acid biosynthetic process; integral to membrane; lipid particle; long-chain fatty acid import; long-chain fatty acid-CoA ligase activity; mitochondrial outer membrane; perinuclear region of cytoplasm; peroxisomal membrane; positive regulation of Golgi to plasma membrane protein transport; positive regulation of phosphatidylcholine biosynthetic process; positive regulation of secretion; response to nutrient; response to organic cyclic compound; very-low-density lipoprotein particle assembly IPR020845; IPR000873; Long-chain-fatty-acid--CoA ligase 3 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 3) (LACS 3) ACSL3 ACS3 FACL3 LACS3 Homo sapiens (Human) TR31220_c1_g1_i1 P10394 POL4_DROME 5.00E-19 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR31220_c2_g2_i1 Q09575 YRD6_CAEEL 3.00E-25 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR31220_c2_g2_i2 P03364 POL_SMRVH 1.00E-09 GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0075713; GO:0090305; GO:0004523; GO:0046718; GO:0008270 DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; establishment of integrated proviral latency; nucleic acid phosphodiester bond hydrolysis; ribonuclease H activity; viral entry into host cell; zinc ion binding IPR001037; IPR001584; IPR017856; IPR003308; IPR012337; IPR002156; IPR000477; IPR010661; Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN)] pol Squirrel monkey retrovirus (SMRV-H) (SMRV-HLB) TR31221_c0_g1_i2 Q9CW42 MOSC1_MOUSE 5.00E-56 GO:0016021; GO:0005743; GO:0005741; GO:0030151; GO:0016491; GO:0030170 integral to membrane; mitochondrial inner membrane; mitochondrial outer membrane; molybdenum ion binding; oxidoreductase activity; pyridoxal phosphate binding IPR005302; IPR005303; IPR011037; "MOSC domain-containing protein 1, mitochondrial (EC 1.-.-.-) (Mitochondrial amidoxime reducing component 1) (mARC1) (Moco sulfurase C-terminal domain-containing protein 1) (Molybdenum cofactor sulfurase C-terminal domain-containing protein 1)" Marc1 Mosc1 Mus musculus (Mouse) TR31221_c0_g1_i3 Q5U534 MOSC1_XENLA 3.00E-55 GO:0016021; GO:0005741; GO:0030151; GO:0016491; GO:0030170 integral to membrane; mitochondrial outer membrane; molybdenum ion binding; oxidoreductase activity; pyridoxal phosphate binding IPR005302; IPR005303; IPR011037; "MOSC domain-containing protein 1, mitochondrial (EC 1.-.-.-)" mosc1 Xenopus laevis (African clawed frog) TR31222_c0_g1_i1 Q9Z1P6 NDUA7_MOUSE 6.00E-17 GO:0042773; GO:0008137; GO:0005743; GO:0005739; GO:0070469 ATP synthesis coupled electron transport; NADH dehydrogenase (ubiquinone) activity; mitochondrial inner membrane; mitochondrion; respiratory chain IPR009947; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (Complex I-B14.5a) (CI-B14.5a) (NADH-ubiquinone oxidoreductase subunit B14.5a) Ndufa7 Mus musculus (Mouse) TR31222_c0_g1_i2 Q9Z1P6 NDUA7_MOUSE 6.00E-17 GO:0042773; GO:0008137; GO:0005743; GO:0005739; GO:0070469 ATP synthesis coupled electron transport; NADH dehydrogenase (ubiquinone) activity; mitochondrial inner membrane; mitochondrion; respiratory chain IPR009947; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (Complex I-B14.5a) (CI-B14.5a) (NADH-ubiquinone oxidoreductase subunit B14.5a) Ndufa7 Mus musculus (Mouse) TR31223_c1_g3_i6 Q54HH2 SRR_DICDI 6.00E-61 GO:0005524; GO:0008721; GO:0070179; GO:0003941; GO:0006563; GO:0005737; GO:0000287; GO:0018249; GO:0030170; GO:0030378 ATP binding; D-serine ammonia-lyase activity; D-serine biosynthetic process; L-serine ammonia-lyase activity; L-serine metabolic process; cytoplasm; magnesium ion binding; protein dehydration; pyridoxal phosphate binding; serine racemase activity IPR001926; Probable serine racemase (EC 4.3.1.17) (EC 4.3.1.18) (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (L-serine ammonia-lyase) (L-serine dehydratase) srr DDB_G0289463 Dictyostelium discoideum (Slime mold) TR31224_c0_g1_i1 Q8CIS0 CAR11_MOUSE 3.00E-11 GO:0031295; GO:0042101; GO:0005737; GO:0045121; GO:0005886; GO:0030890; GO:0043123; GO:0051092; GO:0042102; GO:0001819; GO:0045086; GO:0045577; GO:0045580; GO:0042981; GO:0050776; GO:0007165; GO:0045061 T cell costimulation; T cell receptor complex; cytoplasm; membrane raft; plasma membrane; positive regulation of B cell proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell proliferation; positive regulation of cytokine production; positive regulation of interleukin-2 biosynthetic process; regulation of B cell differentiation; regulation of T cell differentiation; regulation of apoptotic process; regulation of immune response; signal transduction; thymic T cell selection IPR001315; IPR011029; IPR027417; IPR001478; Caspase recruitment domain-containing protein 11 Card11 Mus musculus (Mouse) TR31226_c0_g1_i1 Q8IWZ3 ANKH1_HUMAN 2.00E-07 GO:0003723; GO:0005737; GO:0005634 Q9NRI5 RNA binding; cytoplasm; nucleus IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) TR31226_c0_g1_i2 Q3U0V1 FUBP2_MOUSE 4.00E-19 GO:0003677; GO:0003723; GO:0008380; GO:0010494; GO:0005829; GO:0006397; GO:0051028; GO:0005634; GO:0006355; GO:0006351 "DNA binding; RNA binding; RNA splicing; cytoplasmic stress granule; cytosol; mRNA processing; mRNA transport; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR015096; IPR004087; IPR004088; Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) Khsrp Fubp2 Mus musculus (Mouse) TR31226_c0_g1_i4 P57724 PCBP4_MOUSE 4.00E-07 GO:0003677; GO:0003723; GO:0005737; GO:0030529 DNA binding; RNA binding; cytoplasm; ribonucleoprotein complex IPR004087; IPR004088; Poly(rC)-binding protein 4 (Alpha-CP4) Pcbp4 Mus musculus (Mouse) TR31227_c1_g1_i5 Q8IXM2 BAP18_HUMAN 3.00E-38 GO:0003677; GO:0071339; GO:0016589; GO:0003682; GO:0016568 DNA binding; MLL1 complex; NURF complex; chromatin binding; chromatin modification IPR009057; IPR001005; Chromatin complexes subunit BAP18 (BPTF-associated protein of 18 kDa) BAP18 C17orf49 Homo sapiens (Human) TR31228_c5_g1_i1 Q9H841 NPAL2_HUMAN 3.00E-59 GO:0016021; GO:0015095 integral to membrane; magnesium ion transmembrane transporter activity IPR008521; NIPA-like protein 2 NIPAL2 NPAL2 Homo sapiens (Human) TR31229_c0_g1_i1 Q8C8H8 KY_MOUSE 9.00E-08 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) TR31229_c0_g1_i4 Q8C8H8 KY_MOUSE 8.00E-08 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) TR31230_c0_g2_i2 P42237 GUDP_BACSU 9.00E-12 GO:0016021; GO:0005886; GO:0055085; GO:0005215 integral to membrane; plasma membrane; transmembrane transport; transporter activity IPR004744; IPR011701; IPR020846; IPR016196; Probable glucarate transporter (D-glucarate permease) gudP ycbE BSU02480 Bacillus subtilis (strain 168) TR31230_c0_g2_i3 Q03567 YLD2_CAEEL 9.00E-115 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR011701; IPR020846; IPR016196; Uncharacterized transporter C38C10.2 C38C10.2 Caenorhabditis elegans TR31230_c0_g2_i4 Q9V7S5 PICO_DROME 9.00E-91 GO:0005315; GO:0016021; GO:0015114; GO:0006817; GO:0006814; GO:0015293 Q9V4M9 inorganic phosphate transmembrane transporter activity; integral to membrane; phosphate ion transmembrane transporter activity; phosphate ion transport; sodium ion transport; symporter activity IPR011701; IPR020846; IPR016196; IPR004745; Putative inorganic phosphate cotransporter Picot CG8098 Drosophila melanogaster (Fruit fly) TR31231_c0_g1_i1 Q60876 4EBP1_MOUSE 1.00E-28 GO:0000082; GO:0031929; GO:0005737; GO:0008286; GO:0030324; GO:0031333; GO:0045947; GO:0005634; GO:0045931; GO:0043234; GO:0045471; GO:0030371 G1/S transition of mitotic cell cycle; TOR signaling cascade; cytoplasm; insulin receptor signaling pathway; lung development; negative regulation of protein complex assembly; negative regulation of translational initiation; nucleus; positive regulation of mitotic cell cycle; protein complex; response to ethanol; translation repressor activity IPR008606; Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) Eif4ebp1 Mus musculus (Mouse) TR31233_c2_g5_i1 Q02858 TIE2_MOUSE 9.00E-12 GO:0005524; GO:0048014; GO:0016337; GO:0007160; GO:0005737; GO:0005856; GO:0001935; GO:0005576; GO:0005925; GO:0060347; GO:0030097; GO:0016021; GO:0005887; GO:0016525; GO:2000352; GO:0001569; GO:0005886; GO:0070374; GO:0045766; GO:0010595; GO:0051894; GO:0033138; GO:0043552; GO:0014068; GO:0051897; GO:0030949; GO:0046777; GO:0004713; GO:0004872; GO:0001936; GO:0032878; GO:0032526; GO:0002040; GO:0034446; GO:0004714; GO:0001570 Q60631; Q03160 ATP binding; Tie signaling pathway; cell-cell adhesion; cell-matrix adhesion; cytoplasm; cytoskeleton; endothelial cell proliferation; extracellular region; focal adhesion; heart trabecula formation; hemopoiesis; integral to membrane; integral to plasma membrane; negative regulation of angiogenesis; negative regulation of endothelial cell apoptotic process; patterning of blood vessels; plasma membrane; positive regulation of ERK1 and ERK2 cascade; positive regulation of angiogenesis; positive regulation of endothelial cell migration; positive regulation of focal adhesion assembly; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of vascular endothelial growth factor receptor signaling pathway; protein autophosphorylation; protein tyrosine kinase activity; receptor activity; regulation of endothelial cell proliferation; regulation of establishment or maintenance of cell polarity; response to retinoic acid; sprouting angiogenesis; substrate adhesion-dependent cell spreading; transmembrane receptor protein tyrosine kinase activity; vasculogenesis IPR000742; IPR013032; IPR002049; IPR003961; IPR007110; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR018941; IPR008266; IPR020635; Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b) Tek Hyk Tie-2 Tie2 Mus musculus (Mouse) TR31233_c3_g1_i1 Q9WVM6 TLL2_MOUSE 1.00E-20 GO:0005509; GO:0030154; GO:0005576; GO:0004222; GO:0007275; GO:0006508; GO:0008270 calcium ion binding; cell differentiation; extracellular region; metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Tolloid-like protein 2 (EC 3.4.24.-) Tll2 Mus musculus (Mouse) TR31233_c3_g2_i1 Q5VXM1 CDCP2_HUMAN 7.00E-19 GO:0005576 extracellular region IPR000859; CUB domain-containing protein 2 CDCP2 Homo sapiens (Human) TR31233_c3_g3_i1 Q0VCX1 C1S_BOVIN 3.00E-06 GO:0005509; GO:0006958; GO:0005576; GO:0045087; GO:0006508; GO:0004252 "calcium ion binding; complement activation, classical pathway; extracellular region; innate immune response; proteolysis; serine-type endopeptidase activity" IPR000859; IPR001881; IPR000152; IPR018097; IPR024175; IPR001254; IPR018114; IPR001314; IPR000436; IPR009003; Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain] C1S Bos taurus (Bovine) TR31233_c3_g5_i2 P13497 BMP1_HUMAN 8.00E-20 GO:0005794; GO:0005509; GO:0001502; GO:0030154; GO:0030198; GO:0005576; GO:0005615; GO:0042157; GO:0004222; GO:0001503; GO:0061036; GO:0005578; GO:0006508; GO:0044281; GO:0008270 Golgi apparatus; calcium ion binding; cartilage condensation; cell differentiation; extracellular matrix organization; extracellular region; extracellular space; lipoprotein metabolic process; metalloendopeptidase activity; ossification; positive regulation of cartilage development; proteinaceous extracellular matrix; proteolysis; small molecule metabolic process; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR024079; IPR001506; IPR006026; Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP) BMP1 PCOLC Homo sapiens (Human) TR31233_c3_g5_i3 Q9EQT1 PDGFD_RAT 7.00E-08 GO:0071230; GO:0005576; GO:0016020; GO:0007275; GO:0048008; GO:0051781; GO:0050730 cellular response to amino acid stimulus; extracellular region; membrane; multicellular organismal development; platelet-derived growth factor receptor signaling pathway; positive regulation of cell division; regulation of peptidyl-tyrosine phosphorylation IPR000859; IPR000072; IPR027123; "Platelet-derived growth factor D (PDGF-D) (Iris-expressed growth factor) (Spinal cord-derived growth factor B) (SCDGF-B) [Cleaved into: Platelet-derived growth factor D, latent form (PDGFD latent form); Platelet-derived growth factor D, receptor-binding form (PDGFD receptor-binding form)]" Pdgfd Iegf Scdgfb Rattus norvegicus (Rat) TR31233_c3_g5_i4 Q9WVM6 TLL2_MOUSE 1.00E-19 GO:0005509; GO:0030154; GO:0005576; GO:0004222; GO:0007275; GO:0006508; GO:0008270 calcium ion binding; cell differentiation; extracellular region; metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Tolloid-like protein 2 (EC 3.4.24.-) Tll2 Mus musculus (Mouse) TR31234_c0_g1_i1 Q9NFT7 HXK2_DROME 1.00E-75 GO:0005524; GO:0001678; GO:0005829; GO:0008865; GO:0004340; GO:0006096; GO:0019158 ATP binding; cellular glucose homeostasis; cytosol; fructokinase activity; glucokinase activity; glycolysis; mannokinase activity IPR001312; IPR022673; IPR019807; IPR022672; Carbohydrate metabolism; hexose metabolism. Hexokinase type 2 (EC 2.7.1.1) Hex-t2 Hex CG32849 Drosophila melanogaster (Fruit fly) TR31236_c2_g1_i2 Q9NPB1 NT5M_HUMAN 8.00E-52 GO:0008253; GO:0006260; GO:0046079; GO:0046872; GO:0005759; GO:0000166; GO:0009223; GO:0006206; GO:0046135 5'-nucleotidase activity; DNA replication; dUMP catabolic process; metal ion binding; mitochondrial matrix; nucleotide binding; pyrimidine deoxyribonucleotide catabolic process; pyrimidine nucleobase metabolic process; pyrimidine nucleoside catabolic process IPR010708; IPR023214; "5'(3')-deoxyribonucleotidase, mitochondrial (5',3'-nucleotidase, mitochondrial) (EC 3.1.3.-) (Deoxy-5'-nucleotidase 2) (dNT-2)" NT5M DNT2 Homo sapiens (Human) TR31236_c2_g1_i3 Q8VCE6 NT5M_MOUSE 5.00E-52 GO:0008253; GO:0046079; GO:0046872; GO:0005739; GO:0000166 5'-nucleotidase activity; dUMP catabolic process; metal ion binding; mitochondrion; nucleotide binding IPR010708; IPR023214; "5'(3')-deoxyribonucleotidase, mitochondrial (5',3'-nucleotidase, mitochondrial) (EC 3.1.3.-) (Deoxy-5'-nucleotidase 2) (dNT-2)" Nt5m Dnt2 Mus musculus (Mouse) TR31237_c0_g1_i3 Q4V8E5 MFSD3_RAT 5.00E-69 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR016196; Major facilitator superfamily domain-containing protein 3 Mfsd3 Rattus norvegicus (Rat) TR31238_c1_g1_i1 F1Q930 T237A_DANRE 3.00E-06 GO:0035869; GO:0042384; GO:0016021; GO:0030111 ciliary transition zone; cilium assembly; integral to membrane; regulation of Wnt receptor signaling pathway Transmembrane protein 237A (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog A) tmem237a als2cr4a Danio rerio (Zebrafish) (Brachydanio rerio) TR31238_c1_g2_i1 A9ULX8 TM237_XENLA 4.00E-12 GO:0035869; GO:0042384; GO:0016021; GO:0030111 ciliary transition zone; cilium assembly; integral to membrane; regulation of Wnt receptor signaling pathway Transmembrane protein 237 tmem237 Xenopus laevis (African clawed frog) TR31239_c0_g1_i1 P56670 MAZ_MESAU 5.00E-12 GO:0003677; GO:0046872; GO:0005634; GO:0045944; GO:0006351 "DNA binding; metal ion binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Myc-associated zinc finger protein (MAZI) (Pur-1) (Purine-binding transcription factor) (Fragment) MAZ Mesocricetus auratus (Golden hamster) TR31239_c0_g2_i1 Q96N95 ZN396_HUMAN 1.00E-19 GO:0003677; GO:0005737; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; cytoplasm; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein 396 (Zinc finger and SCAN domain-containing protein 14) ZNF396 ZSCAN14 Homo sapiens (Human) TR31239_c1_g1_i1 Q14590 ZN235_HUMAN 1.00E-48 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) TR31239_c1_g1_i2 P41995 ODD1_CAEEL 4.00E-21 GO:0003677; GO:0046872; GO:0007275; GO:0005634 DNA binding; metal ion binding; multicellular organismal development; nucleus IPR007087; IPR015880; IPR013087; Zinc finger protein odd-1 odd-1 B0280.4 Caenorhabditis elegans TR31240_c0_g1_i2 Q148C8 MIEN1_BOVIN 4.00E-14 GO:0006915; GO:0045454; GO:0005829; GO:0031235; GO:0043066; GO:0030335; GO:0051491; GO:0008430 apoptotic process; cell redox homeostasis; cytosol; intrinsic to internal side of plasma membrane; negative regulation of apoptotic process; positive regulation of cell migration; positive regulation of filopodium assembly; selenium binding IPR011893; IPR012336; Migration and invasion enhancer 1 MIEN1 RDX12 Bos taurus (Bovine) TR31244_c2_g1_i1 Q5ZKN5 FA53A_CHICK 1.00E-07 GO:0005634; GO:0006606 nucleus; protein import into nucleus Protein FAM53A (Dorsal neural-tube nuclear protein) FAM53A DNTNP RCJMB04_33c19 RCJMB04_9o15 Gallus gallus (Chicken) TR31245_c0_g1_i1 Q3UHX9 CI114_MOUSE 2.00E-142 IPR012340; IPR003750; Uncharacterized protein C9orf114 homolog D2Wsu81e Mus musculus (Mouse) TR31245_c0_g1_i2 Q3UHX9 CI114_MOUSE 5.00E-128 IPR012340; IPR003750; Uncharacterized protein C9orf114 homolog D2Wsu81e Mus musculus (Mouse) TR31246_c0_g1_i1 D3ZAT9 FAXC_RAT 2.00E-47 GO:0016021 integral to membrane IPR026928; IPR010987; IPR012336; Failed axon connections homolog Faxc Rattus norvegicus (Rat) TR31248_c2_g1_i1 Q7T308 RN168_DANRE 1.00E-06 GO:0070530; GO:0003682; GO:0006302; GO:0070535; GO:0035518; GO:0036351; GO:0036352; GO:0042393; GO:0045190; GO:0045900; GO:0005634; GO:0045739; GO:0010212; GO:0035861; GO:0000151; GO:0006511; GO:0004842; GO:0008270 K63-linked polyubiquitin binding; chromatin binding; double-strand break repair; histone H2A K63-linked ubiquitination; histone H2A monoubiquitination; histone H2A-K13 ubiquitination; histone H2A-K15 ubiquitination; histone binding; isotype switching; negative regulation of translational elongation; nucleus; positive regulation of DNA repair; response to ionizing radiation; site of double-strand break; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR018957; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF168 (EC 6.3.2.-) (RING finger protein 168) rnf168 zgc:64185 Danio rerio (Zebrafish) (Brachydanio rerio) TR31248_c2_g1_i2 Q810I1 TRI50_RAT 2.00E-08 GO:0016235; GO:0005737; GO:0016874; GO:0070201; GO:0008270 aggresome; cytoplasm; ligase activity; regulation of establishment of protein localization; zinc ion binding IPR001870; IPR003879; IPR008985; IPR006574; IPR018355; IPR003877; IPR000315; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM50 (EC 6.3.2.-) (Tripartite motif-containing protein 50) Trim50 Rattus norvegicus (Rat) TR31248_c4_g1_i1 Q9ESN6 TRIM2_MOUSE 1.00E-13 GO:0005737; GO:0017022; GO:0043523; GO:0004842; GO:0008270 cytoplasm; myosin binding; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) TR31248_c4_g1_i2 O75382 TRIM3_HUMAN 3.00E-16 GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0015031; GO:0008270 cytoplasm; early endosome; nervous system development; protein C-terminus binding; protein transport; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) TR31248_c4_g2_i1 Q5R4I2 RNF8_PONAB 1.00E-07 GO:0051301; GO:0003682; GO:0000781; GO:0006303; GO:0070535; GO:0033523; GO:0042393; GO:0043486; GO:0045190; GO:0030496; GO:0007067; GO:0045900; GO:0005634; GO:0045739; GO:0070936; GO:0042803; GO:0010212; GO:0035861; GO:0007286; GO:0000151; GO:0006511; GO:0004842; GO:0008270 "cell division; chromatin binding; chromosome, telomeric region; double-strand break repair via nonhomologous end joining; histone H2A K63-linked ubiquitination; histone H2B ubiquitination; histone binding; histone exchange; isotype switching; midbody; mitosis; negative regulation of translational elongation; nucleus; positive regulation of DNA repair; protein K48-linked ubiquitination; protein homodimerization activity; response to ionizing radiation; site of double-strand break; spermatid development; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding" IPR017335; IPR000253; IPR008984; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF8 (EC 6.3.2.-) (RING finger protein 8) RNF8 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR31249_c0_g2_i1 Q58D13 DPOA2_BOVIN 6.00E-146 GO:0003677; GO:0006260; GO:0003887; GO:0005634 DNA binding; DNA replication; DNA-directed DNA polymerase activity; nucleus IPR007185; IPR016722; IPR013627; DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) POLA2 Bos taurus (Bovine) TR31250_c0_g1_i1 Q9VCX3 RM45_DROME 7.00E-74 GO:0005762; GO:0003735 mitochondrial large ribosomal subunit; structural constituent of ribosome IPR007379; "Probable 39S ribosomal protein L45, mitochondrial (L45mt) (MRP-L45)" mRpL45 CG6949 Drosophila melanogaster (Fruit fly) TR31254_c7_g1_i3 Q689D1 TLR2_CANFA 4.00E-06 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Canis familiaris (Dog) (Canis lupus familiaris) TR31254_c7_g1_i5 P08953 TOLL_DROME 1.00E-06 GO:0033565; GO:0008063; GO:0019732; GO:0007155; GO:0019955; GO:0050830; GO:0005769; GO:0009897; GO:0007507; GO:0035172; GO:0030097; GO:0045087; GO:0016021; GO:0006963; GO:0006967; GO:0045610; GO:0007416; GO:0016201; GO:0004888; GO:0007352 Itself; Q7K105 ESCRT-0 complex; Toll signaling pathway; antifungal humoral response; cell adhesion; cytokine binding; defense response to Gram-positive bacterium; early endosome; external side of plasma membrane; heart development; hemocyte proliferation; hemopoiesis; innate immune response; integral to membrane; positive regulation of antibacterial peptide biosynthetic process; positive regulation of antifungal peptide biosynthetic process; regulation of hemocyte differentiation; synapse assembly; synaptic target inhibition; transmembrane signaling receptor activity; zygotic specification of dorsal/ventral axis IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) TR31255_c1_g3_i2 O02833 ALS_PAPHA 4.00E-08 GO:0007155; GO:0005615 cell adhesion; extracellular space IPR000483; IPR001611; IPR003591; IPR000372; Insulin-like growth factor-binding protein complex acid labile subunit (ALS) IGFALS ALS Papio hamadryas (Hamadryas baboon) TR31256_c0_g1_i1 Q8BFR5 EFTU_MOUSE 3.00E-138 GO:0005525; GO:0006184; GO:0003924; GO:0005743; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; mitochondrial inner membrane; translation elongation factor activity IPR000795; IPR027417; IPR009000; IPR009001; IPR004161; IPR004541; IPR004160; "Elongation factor Tu, mitochondrial" Tufm Mus musculus (Mouse) TR31257_c0_g1_i1 P55067 NCAN_RAT 3.00E-10 GO:0005509; GO:0030246; GO:0007155; GO:0005576; GO:0005540; GO:0005886 calcium ion binding; carbohydrate binding; cell adhesion; extracellular region; hyaluronic acid binding; plasma membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Neurocan core protein (245 kDa early postnatal core glycoprotein) (Chondroitin sulfate proteoglycan 3) [Cleaved into: 150 kDa adult core glycoprotein] Ncan Cspg3 Rattus norvegicus (Rat) TR31257_c0_g1_i3 Q8BNA6 FAT3_MOUSE 6.00E-11 GO:0005509; GO:0007156; GO:0016021; GO:0007275; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; multicellular organismal development; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Protocadherin Fat 3 (FAT tumor suppressor homolog 3) Fat3 Gm1132 Gm510 Mus musculus (Mouse) TR31259_c0_g2_i1 P29693 EF1D_XENLA 1.00E-54 GO:0005853; GO:0003746 eukaryotic translation elongation factor 1 complex; translation elongation factor activity IPR018940; IPR014717; IPR001326; IPR014038; Elongation factor 1-delta (EF-1-delta) (P36) eef1d Xenopus laevis (African clawed frog) TR31260_c0_g1_i1 Q49117 Y182_METEA 1.00E-34 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Uncharacterized oxidoreductase MexAM1_META1p0182 (EC 1.-.-.-) (ORFC) MexAM1_META1p0182 Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1) TR31262_c0_g1_i1 Q9JJX7 TYDP2_MOUSE 6.00E-45 GO:0070260; GO:0016605; GO:0005737; GO:0006302; GO:0004519; GO:0000287; GO:0030145; GO:0005730; GO:0003697; GO:0036317 5'-tyrosyl-DNA phosphodiesterase activity; PML body; cytoplasm; double-strand break repair; endonuclease activity; magnesium ion binding; manganese ion binding; nucleolus; single-stranded DNA binding; tyrosyl-RNA phosphodiesterase activity IPR005135; Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (TRAF and TNF receptor-associated protein) Tdp2 Ttrap Mus musculus (Mouse) TR31262_c0_g1_i2 O95551 TYDP2_HUMAN 7.00E-51 GO:0070260; GO:0016605; GO:0007166; GO:0005737; GO:0006302; GO:0000287; GO:0030145; GO:0004518; GO:0090305; GO:0005730; GO:0003697; GO:0003714; GO:0036317 5'-tyrosyl-DNA phosphodiesterase activity; PML body; cell surface receptor signaling pathway; cytoplasm; double-strand break repair; magnesium ion binding; manganese ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleolus; single-stranded DNA binding; transcription corepressor activity; tyrosyl-RNA phosphodiesterase activity IPR005135; IPR009060; Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase) TDP2 EAP2 TTRAP AD-022 Homo sapiens (Human) TR31263_c0_g1_i2 P05375 PEM2_YEAST 3.00E-53 GO:0005789; GO:0016021; GO:0080101; GO:0000773; GO:0006656; GO:0004608 endoplasmic reticulum membrane; integral to membrane; phosphatidyl-N-dimethylethanolamine N-methyltransferase activity; phosphatidyl-N-methylethanolamine N-methyltransferase activity; phosphatidylcholine biosynthetic process; phosphatidylethanolamine N-methyltransferase activity IPR024960; IPR007318; Phospholipid metabolism; phosphatidylcholine biosynthesis. Phosphatidyl-N-methylethanolamine N-methyltransferase (PLMT) (EC 2.1.1.17) (EC 2.1.1.71) (Overproducer of inositol protein 3) (Unsaturated phospholipid methyltransferase) OPI3 PEM2 YJR073C J1824 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR31266_c0_g1_i2 Q9D404 OXSM_MOUSE 4.00E-158 GO:0004315; GO:0006637; GO:0051792; GO:0005739; GO:0051790 3-oxoacyl-[acyl-carrier-protein] synthase activity; acyl-CoA metabolic process; medium-chain fatty acid biosynthetic process; mitochondrion; short-chain fatty acid biosynthetic process IPR017568; IPR018201; IPR014031; IPR014030; IPR016039; IPR016038; Lipid metabolism; fatty acid biosynthesis. "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (EC 2.3.1.41) (Beta-ketoacyl-ACP synthase)" Oxsm Mus musculus (Mouse) TR31266_c0_g1_i3 Q8L3X9 KASM_ARATH 4.00E-125 GO:0004315; GO:0006633; GO:0005739 3-oxoacyl-[acyl-carrier-protein] synthase activity; fatty acid biosynthetic process; mitochondrion IPR017568; IPR018201; IPR014031; IPR014030; IPR016039; IPR016038; Lipid metabolism; fatty acid biosynthesis. "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (EC 2.3.1.41) (Beta-ketoacyl-ACP synthase) (mtKAS)" KAS At2g04540 T1O3.5 Arabidopsis thaliana (Mouse-ear cress) TR31268_c0_g2_i1 Q9ESS0 DUS10_MOUSE 2.00E-90 GO:0005794; GO:0017017; GO:0005737; GO:0046329; GO:0043508; GO:0060266; GO:0005634; GO:0035335; GO:0004725; GO:0002819; GO:0032496 Golgi apparatus; MAP kinase tyrosine/serine/threonine phosphatase activity; cytoplasm; negative regulation of JNK cascade; negative regulation of JUN kinase activity; negative regulation of respiratory burst involved in inflammatory response; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; regulation of adaptive immune response; response to lipopolysaccharide IPR020417; IPR000340; IPR020422; IPR024950; IPR008343; IPR001763; IPR000387; IPR016130; Dual specificity protein phosphatase 10 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5) Dusp10 Mkp5 Mus musculus (Mouse) TR31269_c3_g1_i2 Q8NEE8 TTC16_HUMAN 2.00E-54 IPR013026; IPR011990; IPR013105; IPR019734; Tetratricopeptide repeat protein 16 (TPR repeat protein 16) TTC16 Homo sapiens (Human) TR31270_c1_g1_i2 Q922Z0 OXDD_MOUSE 4.00E-70 GO:0019478; GO:0003884; GO:0008445; GO:0006533; GO:0006531; GO:0048037; GO:0007625; GO:0042445; GO:0007320; GO:0005777 D-amino acid catabolic process; D-amino-acid oxidase activity; D-aspartate oxidase activity; aspartate catabolic process; aspartate metabolic process; cofactor binding; grooming behavior; hormone metabolic process; insemination; peroxisome IPR023209; IPR006181; IPR006076; D-aspartate oxidase (DASOX) (DDO) (EC 1.4.3.1) Ddo Mus musculus (Mouse) TR31270_c1_g1_i3 O01739 OXDA1_CAEEL 2.00E-42 GO:0003884 D-amino-acid oxidase activity IPR023209; IPR006181; IPR006076; IPR016040; Putative D-amino-acid oxidase 1 (DAAO 1) (DAMOX 1) (DAO 1) (EC 1.4.3.-) F20H11.5 Caenorhabditis elegans TR31272_c0_g1_i1 Q575T0 CYGB1_ORYLA 6.00E-09 GO:0005737; GO:0020037; GO:0005506; GO:0019825; GO:0005344 cytoplasm; heme binding; iron ion binding; oxygen binding; oxygen transporter activity IPR000971; IPR009050; IPR012292; IPR013314; Cytoglobin-1 cygb1 cygb-1 Oryzias latipes (Medaka fish) (Japanese ricefish) TR31272_c0_g1_i2 Q575T0 CYGB1_ORYLA 6.00E-09 GO:0005737; GO:0020037; GO:0005506; GO:0019825; GO:0005344 cytoplasm; heme binding; iron ion binding; oxygen binding; oxygen transporter activity IPR000971; IPR009050; IPR012292; IPR013314; Cytoglobin-1 cygb1 cygb-1 Oryzias latipes (Medaka fish) (Japanese ricefish) TR31273_c0_g1_i1 O70445 BARD1_MOUSE 7.00E-10 GO:0070531; GO:0031436; GO:0006281; GO:0003723; GO:0005737; GO:0016874; GO:0043066; GO:0046826; GO:0043065; GO:0085020; GO:0046982; GO:0042803; GO:0042325; GO:0008270 BRCA1-A complex; BRCA1-BARD1 complex; DNA repair; RNA binding; cytoplasm; ligase activity; negative regulation of apoptotic process; negative regulation of protein export from nucleus; positive regulation of apoptotic process; protein K6-linked ubiquitination; protein heterodimerization activity; protein homodimerization activity; regulation of phosphorylation; zinc ion binding IPR002110; IPR020683; IPR001357; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. BRCA1-associated RING domain protein 1 (BARD-1) (EC 6.3.2.-) Bard1 Mus musculus (Mouse) TR31273_c0_g1_i2 Q9J5I3 V018_FOWPN 7.00E-10 IPR002110; IPR020683; IPR018272; Putative ankyrin repeat protein FPV018 FPV018 Fowlpox virus (strain NVSL) (FPV) TR31273_c1_g1_i1 Q5E9N5 CLPB_BOVIN 4.00E-117 GO:0005524; GO:0034605; GO:0017111 ATP binding; cellular response to heat; nucleoside-triphosphatase activity IPR003593; IPR002110; IPR020683; IPR013093; IPR019489; IPR001270; IPR027417; Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3) CLPB SKD3 Bos taurus (Bovine) TR31273_c1_g1_i2 Q89UL2 CLPB_BRAJA 7.00E-55 GO:0005524; GO:0005737; GO:0017111; GO:0016485; GO:0009408 ATP binding; cytoplasm; nucleoside-triphosphatase activity; protein processing; response to heat IPR003593; IPR013093; IPR003959; IPR017730; IPR019489; IPR004176; IPR001270; IPR018368; IPR028299; IPR023150; IPR027417; Chaperone protein ClpB clpB blr1404 Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110) TR31277_c0_g1_i1 Q34949 NU4M_LUMTE 6.00E-91 GO:0008137; GO:0016021; GO:0006120; GO:0031966; GO:0070469 "NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial electron transport, NADH to ubiquinone; mitochondrial membrane; respiratory chain" IPR001750; IPR003918; IPR000260; NADH-ubiquinone oxidoreductase chain 4 (EC 1.6.5.3) (NADH dehydrogenase subunit 4) ND4 Lumbricus terrestris (Common earthworm) TR31279_c0_g1_i1 Q5F478 ANR44_CHICK 4.00E-10 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) TR31280_c1_g1_i2 Q4N4N8 TXND_THEPA 3.00E-18 GO:0045454; GO:0005789; GO:0006662; GO:0016021; GO:0015035 cell redox homeostasis; endoplasmic reticulum membrane; glycerol ether metabolic process; integral to membrane; protein disulfide oxidoreductase activity IPR005746; IPR012336; IPR013766; Thioredoxin domain-containing protein (Membrane protein 23) (mp23) TP02_0602 Theileria parva (East coast fever infection agent) TR31280_c2_g1_i2 Q9CQI9 MED30_MOUSE 6.00E-34 GO:0001104; GO:0030521; GO:0016592; GO:0045893; GO:0004872; GO:0019827; GO:0006367 Q15528 "RNA polymerase II transcription cofactor activity; androgen receptor signaling pathway; mediator complex; positive regulation of transcription, DNA-dependent; receptor activity; stem cell maintenance; transcription initiation from RNA polymerase II promoter" IPR021019; Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (Thyroid hormone receptor-associated protein 6) (Thyroid hormone receptor-associated protein complex 25 kDa component) (Trap25) Med30 Thrap6 Trap25 Mus musculus (Mouse) TR31281_c3_g1_i1 P78424 PO6F2_HUMAN 2.00E-08 GO:0007417; GO:0007402; GO:0005634; GO:0043565; GO:0003700; GO:0006366; GO:0007601 central nervous system development; ganglion mother cell fate determination; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; visual perception IPR001356; IPR009057; IPR010982; IPR013847; IPR015585; IPR000327; "POU domain, class 6, transcription factor 2 (Retina-derived POU domain factor 1) (RPF-1)" POU6F2 RPF1 Homo sapiens (Human) TR31281_c4_g1_i1 Q29013 PO2F2_PIG 2.00E-42 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; IPR010982; IPR013847; IPR000327; IPR000972; "POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2)" POU2F2 OCT2 OTF2 Sus scrofa (Pig) TR31284_c0_g1_i1 Q8BSN3 CC151_MOUSE 2.00E-38 Coiled-coil domain-containing protein 151 Ccdc151 Mus musculus (Mouse) TR31287_c8_g2_i2 Q9ES53 UFD1_RAT 5.00E-111 GO:0005829; GO:0005634; GO:0043161 cytosol; nucleus; proteasomal ubiquitin-dependent protein catabolic process IPR004854; Protein degradation; proteasomal ubiquitin-dependent pathway. Ubiquitin fusion degradation protein 1 homolog (UB fusion protein 1) Ufd1l Rattus norvegicus (Rat) TR31288_c3_g1_i1 Q05654 RTF21_SCHPO 4.00E-81 TR31288_c3_g1_i2 Q09575 YRD6_CAEEL 5.00E-72 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR31288_c3_g1_i3 Q4R6I1 GIN1_MACFA 2.00E-14 GO:0015074; GO:0003676 DNA integration; nucleic acid binding IPR001584; IPR012337; IPR015416; Gypsy retrotransposon integrase-like protein 1 (GIN-1) GIN1 QtsA-18003 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR31288_c3_g2_i3 B9DHT4 ARIA_ARATH 8.00E-06 GO:0010187; GO:0005634; GO:0005886; GO:0016567; GO:0009737; GO:0009651 negative regulation of seed germination; nucleus; plasma membrane; protein ubiquitination; response to abscisic acid stimulus; response to salt stress IPR011989; IPR016024; IPR000225; IPR000210; IPR011333; IPR013069; Protein modification; protein ubiquitination. ARM REPEAT PROTEIN INTERACTING WITH ABF2 (ARIA) ARIA At5g19330 F7K24.80 Arabidopsis thaliana (Mouse-ear cress) TR31289_c1_g2_i1 O34678 YTBE_BACSU 3.00E-36 GO:0016491 oxidoreductase activity IPR001395; IPR018170; IPR020471; IPR023210; Uncharacterized oxidoreductase YtbE (EC 1.-.-.-) ytbE BSU29050 Bacillus subtilis (strain 168) TR31289_c3_g1_i2 P06632 DKGA_CORSC 3.00E-34 GO:0019853; GO:0005737; GO:0016491 L-ascorbic acid biosynthetic process; cytoplasm; oxidoreductase activity IPR001395; IPR018170; IPR020471; IPR023210; "2,5-diketo-D-gluconic acid reductase A (2,5-DKG reductase A) (2,5-DKGR A) (25DKGR-A) (EC 1.1.1.346) (AKR5C)" dkgA Corynebacterium sp. (strain ATCC 31090) TR31289_c3_g1_i3 A0QV10 Y2408_MYCS2 2.00E-48 GO:0016491 oxidoreductase activity IPR001395; IPR018170; IPR020471; IPR023210; Uncharacterized oxidoreductase MSMEG_2408/MSMEI_2347 (EC 1.-.-.-) MSMEG_2408 MSMEI_2347 Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) TR31289_c4_g1_i1 Q09632 YOF5_CAEEL 3.00E-32 GO:0016491 oxidoreductase activity IPR001395; IPR018170; IPR020471; IPR023210; Uncharacterized oxidoreductase ZK1290.5 (EC 1.-.-.-) ZK1290.5 Caenorhabditis elegans TR31289_c4_g1_i5 O14088 YER5_SCHPO 8.00E-34 GO:0042843; GO:0032866; GO:0032867; GO:0019568; GO:0005829; GO:0005634 D-xylose catabolic process; D-xylose:NADP reductase activity; L-arabinose:NADP reductase activity; arabinose catabolic process; cytosol; nucleus IPR001395; IPR018170; IPR020471; IPR023210; Uncharacterized oxidoreductase C2F3.05c (EC 1.-.-.-) SPAC2F3.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR31289_c5_g1_i1 P49378 XYL1_KLULA 2.00E-17 GO:0042843; GO:0016491 D-xylose catabolic process; oxidoreductase activity IPR001395; IPR018170; IPR020471; IPR023210; Carbohydrate metabolism; D-xylose degradation. NAD(P)H-dependent D-xylose reductase (XR) (EC 1.1.1.307) XYL1 KLLA0E21714g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR31289_c5_g1_i2 P76234 YEAE_ECOLI 2.00E-12 GO:0051596; GO:0016491 methylglyoxal catabolic process; oxidoreductase activity IPR001395; IPR020471; IPR023210; Uncharacterized protein YeaE yeaE b1781 JW1770 Escherichia coli (strain K12) TR31290_c3_g1_i2 Q52L45 ILEU_XENLA 1.00E-61 GO:0005737; GO:0005615; GO:0004867 cytoplasm; extracellular space; serine-type endopeptidase inhibitor activity IPR023795; IPR023796; IPR000215; Leukocyte elastase inhibitor (Serpin B1) serpinb1 Xenopus laevis (African clawed frog) TR31290_c3_g1_i5 P07385 SPI2_CWPXB 4.00E-12 GO:0004869; GO:0005615; GO:0030430; GO:0039650 cysteine-type endopeptidase inhibitor activity; extracellular space; host cell cytoplasm; suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process IPR023795; IPR023796; IPR000215; Serine proteinase inhibitor 2 (Serp-2) (Serpin-2) (Cytokine response modifier protein A) (Hemorrhage-inducing 38 kDa protein) (ICE inhibitor) CRMA SPI-2 CPXV207 Cowpox virus (strain Brighton Red) (CPV) TR31292_c0_g1_i1 Q3USY0 S38AB_MOUSE 2.00E-100 GO:0006865; GO:0016021; GO:0006814 amino acid transport; integral to membrane; sodium ion transport IPR013057; Putative sodium-coupled neutral amino acid transporter 11 (Solute carrier family 38 member 11) Slc38a11 Mus musculus (Mouse) TR31292_c0_g1_i3 Q3USY0 S38AB_MOUSE 2.00E-92 GO:0006865; GO:0016021; GO:0006814 amino acid transport; integral to membrane; sodium ion transport IPR013057; Putative sodium-coupled neutral amino acid transporter 11 (Solute carrier family 38 member 11) Slc38a11 Mus musculus (Mouse) TR31293_c0_g3_i3 Q96MU7 YTDC1_HUMAN 9.00E-66 GO:0008380; GO:0006397; GO:0005634 Q96SB4; P78362 RNA splicing; mRNA processing; nucleus IPR007275; YTH domain-containing protein 1 (Putative splicing factor YT521) YTHDC1 KIAA1966 YT521 Homo sapiens (Human) TR31295_c2_g1_i1 P80017 GLBD_CAUAR 4.00E-08 GO:0020037; GO:0005506; GO:0019825; GO:0005344 heme binding; iron ion binding; oxygen binding; oxygen transporter activity IPR000971; IPR009050; IPR012292; "Globin D, coelomic" Caudina arenicola (Sea cucumber) (Molpadia arenicola) TR31295_c2_g1_i10 Q575T0 CYGB1_ORYLA 3.00E-14 GO:0005737; GO:0020037; GO:0005506; GO:0019825; GO:0005344 cytoplasm; heme binding; iron ion binding; oxygen binding; oxygen transporter activity IPR000971; IPR009050; IPR012292; IPR013314; Cytoglobin-1 cygb1 cygb-1 Oryzias latipes (Medaka fish) (Japanese ricefish) TR31295_c2_g1_i2 Q575T0 CYGB1_ORYLA 2.00E-14 GO:0005737; GO:0020037; GO:0005506; GO:0019825; GO:0005344 cytoplasm; heme binding; iron ion binding; oxygen binding; oxygen transporter activity IPR000971; IPR009050; IPR012292; IPR013314; Cytoglobin-1 cygb1 cygb-1 Oryzias latipes (Medaka fish) (Japanese ricefish) TR31295_c2_g1_i7 Q90YJ2 NGB_DANRE 1.00E-11 GO:0005737; GO:0020037; GO:0005506; GO:0019825; GO:0005344; GO:0043204; GO:0001666 cytoplasm; heme binding; iron ion binding; oxygen binding; oxygen transporter activity; perikaryon; response to hypoxia IPR000971; IPR009050; IPR012292; IPR001032; Neuroglobin ngb si:ch211-233n24.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR31295_c2_g1_i9 P80017 GLBD_CAUAR 1.00E-08 GO:0020037; GO:0005506; GO:0019825; GO:0005344 heme binding; iron ion binding; oxygen binding; oxygen transporter activity IPR000971; IPR009050; IPR012292; "Globin D, coelomic" Caudina arenicola (Sea cucumber) (Molpadia arenicola) TR31296_c0_g2_i1 Q8CC88 VWA8_MOUSE 1.00E-23 GO:0005524; GO:0006200; GO:0016887; GO:0005576; GO:0005739 ATP binding; ATP catabolic process; ATPase activity; extracellular region; mitochondrion IPR003593; IPR011704; IPR027417; IPR002035; von Willebrand factor A domain-containing protein 8 Vwa8 Kiaa0564 Mus musculus (Mouse) TR31296_c0_g2_i3 A3KMH1 VWA8_HUMAN 0 GO:0005524; GO:0006200; GO:0016887; GO:0005576; GO:0005739 ATP binding; ATP catabolic process; ATPase activity; extracellular region; mitochondrion IPR003593; IPR011704; IPR027417; IPR002035; von Willebrand factor A domain-containing protein 8 VWA8 KIAA0564 Homo sapiens (Human) TR31296_c0_g2_i4 B0R0T1 VWA8_DANRE 0 GO:0005524; GO:0006200; GO:0016887 ATP binding; ATP catabolic process; ATPase activity IPR003593; IPR011704; IPR027417; IPR002035; von Willebrand factor A domain-containing protein 8 si:dkey-18l1.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR31296_c0_g4_i1 B0R0T1 VWA8_DANRE 2.00E-130 GO:0005524; GO:0006200; GO:0016887 ATP binding; ATP catabolic process; ATPase activity IPR003593; IPR011704; IPR027417; IPR002035; von Willebrand factor A domain-containing protein 8 si:dkey-18l1.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR31297_c0_g1_i2 P85971 6PGL_RAT 8.00E-73 GO:0017057; GO:0005737; GO:0048029; GO:0009051 "6-phosphogluconolactonase activity; cytoplasm; monosaccharide binding; pentose-phosphate shunt, oxidative branch" IPR005900; IPR006148; Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3. 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) Pgls Rattus norvegicus (Rat) TR31299_c6_g1_i1 P10895 PLCD1_BOVIN 6.00E-59 GO:0001525; GO:0005509; GO:0005829; GO:0035556; GO:0060716; GO:0016042; GO:0004435; GO:0005543; GO:0042127; GO:0004871 angiogenesis; calcium ion binding; cytosol; intracellular signal transduction; labyrinthine layer blood vessel development; lipid catabolic process; phosphatidylinositol phospholipase C activity; phospholipid binding; regulation of cell proliferation; signal transducer activity IPR000008; IPR011992; IPR018247; IPR002048; IPR011993; IPR001192; IPR017946; IPR001849; IPR015359; IPR000909; IPR001711; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-1) (Phospholipase C-III) (PLC-III) (Phospholipase C-delta-1) (PLC-delta-1)" PLCD1 Bos taurus (Bovine) TR31299_c7_g1_i1 Q07722 PLCB4_BOVIN 9.00E-37 GO:0005509; GO:0035556; GO:0016042; GO:0004435; GO:0004871 calcium ion binding; intracellular signal transduction; lipid catabolic process; phosphatidylinositol phospholipase C activity; signal transducer activity IPR000008; IPR011992; IPR001192; IPR016280; IPR009535; IPR017946; IPR015359; IPR000909; IPR001711; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (PCL-C1) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4) (Fragment)" PLCB4 Bos taurus (Bovine) TR31301_c0_g1_i2 Q6DCP5 SAAL1_XENLA 8.00E-71 GO:0006953; GO:0005576 acute-phase response; extracellular region IPR000096; Protein saal1 saal1 Xenopus laevis (African clawed frog) TR31301_c0_g1_i3 Q6DCP5 SAAL1_XENLA 3.00E-53 GO:0006953; GO:0005576 acute-phase response; extracellular region IPR000096; Protein saal1 saal1 Xenopus laevis (African clawed frog) TR31302_c2_g1_i1 Q9SZR0 CHMO_ARATH 4.00E-103 GO:0051537; GO:0019439; GO:0009570; GO:0019133; GO:0019285; GO:0005506; GO:0016708 "2 iron, 2 sulfur cluster binding; aromatic compound catabolic process; chloroplast stroma; choline monooxygenase activity; glycine betaine biosynthetic process from choline; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor" IPR017941; IPR015879; IPR001663; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1. "Choline monooxygenase, chloroplastic (EC 1.14.15.7)" At4g29890 F27B13.130 Arabidopsis thaliana (Mouse-ear cress) TR31302_c2_g1_i3 Q52028 BPHA_PSEPS 6.00E-19 GO:0051537; GO:0019439; GO:0018687; GO:0005506 "2 iron, 2 sulfur cluster binding; aromatic compound catabolic process; biphenyl 2,3-dioxygenase activity; iron ion binding" IPR017941; IPR015881; IPR015879; IPR001663; "Xenobiotic degradation; biphenyl degradation; 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 1/4." "Biphenyl dioxygenase subunit alpha (EC 1.14.12.18) (Biphenyl 2,3-dioxygenase)" bphA bphA1 Pseudomonas pseudoalcaligenes TR31304_c0_g1_i1 Q6UL01 MORN2_MOUSE 3.00E-23 IPR003409; MORN repeat-containing protein 2 (MORN motif protein in testis) Morn2 Mopt Mus musculus (Mouse) TR31304_c0_g1_i2 Q8WYR4 RSPH1_HUMAN 7.00E-14 GO:0005829; GO:0007126; GO:0005634 cytosol; meiosis; nucleus IPR003409; Radial spoke head 1 homolog (Cancer/testis antigen 79) (CT79) (Male meiotic metaphase chromosome-associated acidic protein) (Meichroacidin) (Testis-specific gene A2 protein) RSPH1 TSA2 TSGA2 Homo sapiens (Human) TR31304_c0_g1_i4 Q56YP2 PI5K1_ARATH 1.00E-14 GO:0016308; GO:0005524; GO:0051015; GO:0003785; GO:0005886; GO:0006950 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding; actin filament binding; actin monomer binding; plasma membrane; response to stress IPR003409; IPR017163; IPR023610; IPR027483; IPR002498; IPR027484; IPR016034; Phosphatidylinositol 4-phosphate 5-kinase 1 (AtPIP5K1) (EC 2.7.1.68) (1-phosphatidylinositol 4-phosphate kinase 1) (Diphosphoinositide kinase 1) (PtdIns(4)P-5-kinase 1) PIP5K1 P5K1 At1g21980 F2E2.1 Arabidopsis thaliana (Mouse-ear cress) TR31306_c0_g1_i1 Q5RDI0 SRBD1_PONAB 9.00E-98 GO:0003723; GO:0016788; GO:0006139 "RNA binding; hydrolase activity, acting on ester bonds; nucleobase-containing compound metabolic process" IPR012340; IPR003029; IPR022967; IPR012337; IPR010994; IPR023323; IPR023319; IPR018974; IPR023097; IPR006641; S1 RNA-binding domain-containing protein 1 SRBD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR31306_c1_g1_i1 O06147 RS1_MYCTU 3.00E-08 GO:0003723; GO:0005618; GO:0005829; GO:0040007; GO:0005886; GO:0005840; GO:0003735; GO:0006412 RNA binding; cell wall; cytosol; growth; plasma membrane; ribosome; structural constituent of ribosome; translation IPR012340; IPR003029; IPR000110; IPR022967; 30S ribosomal protein S1 rpsA Rv1630 MT1666 MTCY01B2.22 Mycobacterium tuberculosis TR31309_c2_g1_i1 P21783 NOTCH_XENLA 1.00E-25 GO:0007219; GO:0005509; GO:0030154; GO:0016021; GO:0000122; GO:0007399; GO:0005654; GO:0004872; GO:0050793 Notch signaling pathway; calcium ion binding; cell differentiation; integral to membrane; negative regulation of transcription from RNA polymerase II promoter; nervous system development; nucleoplasm; receptor activity; regulation of developmental process IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022362; IPR000800; IPR010660; IPR011656; Neurogenic locus notch protein homolog (xOTCH) notch1 xotch Xenopus laevis (African clawed frog) TR31312_c2_g1_i1 P39694 COMEA_BACSU 2.00E-06 GO:0003677; GO:0006281; GO:0030420; GO:0016021; GO:0005886 DNA binding; DNA repair; establishment of competence for transformation; integral to membrane; plasma membrane IPR004787; IPR004509; IPR000445; IPR003583; IPR010994; IPR019554; ComE operon protein 1 comEA comE1 BSU25590 Bacillus subtilis (strain 168) TR31312_c3_g1_i1 Q7L9B9 EEPD1_HUMAN 1.00E-42 GO:0003677; GO:0006281 DNA binding; DNA repair IPR004509; IPR005135; IPR003583; IPR010994; Endonuclease/exonuclease/phosphatase family domain-containing protein 1 EEPD1 KIAA1706 Homo sapiens (Human) TR31312_c3_g2_i1 Q6TEQ0 EEPD1_DANRE 6.00E-48 GO:0003677; GO:0006281 DNA binding; DNA repair IPR005135; IPR003583; IPR010994; Endonuclease/exonuclease/phosphatase family domain-containing protein 1 eepd1 zgc:77395 Danio rerio (Zebrafish) (Brachydanio rerio) TR31313_c0_g2_i1 Q1JQC1 MFSD1_BOVIN 3.00E-57 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Major facilitator superfamily domain-containing protein 1 MFSD1 Bos taurus (Bovine) TR31314_c6_g1_i1 Q9VW71 FAT2_DROME 9.00E-08 GO:0009925; GO:0005509; GO:0016339; GO:0050839; GO:0050829; GO:0042247; GO:0030950; GO:0005925; GO:0007440; GO:0007295; GO:0007442; GO:0007156; GO:0005887; GO:0045571; GO:0007424; GO:0045089; GO:0004872; GO:0007431 basal plasma membrane; calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; defense response to Gram-negative bacterium; establishment of planar polarity of follicular epithelium; establishment or maintenance of actin cytoskeleton polarity; focal adhesion; foregut morphogenesis; growth of a germarium-derived egg chamber; hindgut morphogenesis; homophilic cell adhesion; integral to plasma membrane; negative regulation of imaginal disc growth; open tracheal system development; positive regulation of innate immune response; receptor activity; salivary gland development IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Fat-like cadherin-related tumor suppressor homolog (Protein kugelei) kug fat2 CG7749 Drosophila melanogaster (Fruit fly) TR31320_c5_g1_i1 Q4UMH6 Y381_RICFE 7.00E-12 GO:0015969 guanosine tetraphosphate metabolic process IPR002110; IPR020683; IPR007685; Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR31321_c2_g2_i1 Q2VB19 PUM1_CHICK 5.00E-08 GO:0003723; GO:0005737; GO:0006417 RNA binding; cytoplasm; regulation of translation IPR011989; IPR016024; IPR001313; Pumilio homolog 1 PUM1 RCJMB04_1f11 Gallus gallus (Chicken) TR31321_c4_g1_i2 P25822 PUM_DROME 3.00E-175 GO:0008595; GO:0048149; GO:0001709; GO:0005737; GO:0048813; GO:0042078; GO:0008258; GO:0007616; GO:0003730; GO:0007067; GO:0097482; GO:0045786; GO:0042059; GO:0045892; GO:0031594; GO:0000288; GO:0048477; GO:0007280; GO:0045727; GO:0008582; GO:0050804; GO:0000900; GO:0061176; GO:0061177 "anterior/posterior axis specification, embryo; behavioral response to ethanol; cell fate determination; cytoplasm; dendrite morphogenesis; germ-line stem cell division; head involution; long-term memory; mRNA 3'-UTR binding; mitosis; muscle cell postsynaptic density; negative regulation of cell cycle; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of transcription, DNA-dependent; neuromuscular junction; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; oogenesis; pole cell migration; positive regulation of translation; regulation of synaptic growth at neuromuscular junction; regulation of synaptic transmission; translation repressor activity, nucleic acid binding; type Ib terminal bouton; type Is terminal bouton" IPR011989; IPR016024; IPR001313; Maternal protein pumilio pum CG9755 Drosophila melanogaster (Fruit fly) TR31321_c4_g1_i3 Q8TB72 PUM2_HUMAN 0 GO:0003723; GO:0010494; GO:0048471; GO:0006417; GO:0034063 Q9NQZ3; Q9Q2G4 RNA binding; cytoplasmic stress granule; perinuclear region of cytoplasm; regulation of translation; stress granule assembly IPR011989; IPR016024; IPR001313; Pumilio homolog 2 (Pumilio-2) PUM2 KIAA0235 PUMH2 Homo sapiens (Human) TR31323_c1_g1_i1 Q8K1A5 TM41B_MOUSE 2.00E-94 GO:0016021 integral to membrane IPR015414; Transmembrane protein 41B Tmem41b D7Ertd743e Kiaa0033 Mus musculus (Mouse) TR31324_c0_g1_i1 Q6C2X0 KAPR_YARLI 3.00E-06 GO:0030552; GO:0005952; GO:0008603 cAMP binding; cAMP-dependent protein kinase complex; cAMP-dependent protein kinase regulator activity IPR002373; IPR012198; IPR003117; IPR018490; IPR018488; IPR000595; IPR014710; cAMP-dependent protein kinase regulatory subunit (PKA regulatory subunit) PKAR YALI0F04422g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR31326_c0_g1_i1 Q8BTF7 DNLI4_MOUSE 2.00E-30 GO:0005524; GO:0003677; GO:0003910; GO:0032807; GO:0051102; GO:0051103; GO:0005958; GO:0033077; GO:0033153; GO:0007049; GO:0051301; GO:0008283; GO:0007417; GO:0005694; GO:0051276; GO:0000793; GO:0005737; GO:0006303; GO:0005925; GO:0033152; GO:0001701; GO:0045190; GO:0006273; GO:0046872; GO:0043524; GO:0051402; GO:0006289; GO:0006297; GO:0005886; GO:0048146; GO:0050769; GO:0002328; GO:0010165; GO:0010332; GO:0000012; GO:0035019 "ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligase IV complex; DNA ligation involved in DNA recombination; DNA ligation involved in DNA repair; DNA-dependent protein kinase-DNA ligase 4 complex; T cell differentiation in thymus; T cell receptor V(D)J recombination; cell cycle; cell division; cell proliferation; central nervous system development; chromosome; chromosome organization; condensed chromosome; cytoplasm; double-strand break repair via nonhomologous end joining; focal adhesion; immunoglobulin V(D)J recombination; in utero embryonic development; isotype switching; lagging strand elongation; metal ion binding; negative regulation of neuron apoptotic process; neuron apoptotic process; nucleotide-excision repair; nucleotide-excision repair, DNA gap filling; plasma membrane; positive regulation of fibroblast proliferation; positive regulation of neurogenesis; pro-B cell differentiation; response to X-ray; response to gamma radiation; single strand break repair; somatic stem cell maintenance" IPR001357; IPR000977; IPR012309; IPR012310; IPR016059; IPR012308; IPR021536; IPR012340; DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) Lig4 Mus musculus (Mouse) TR31326_c2_g1_i2 Q54CR9 DNLI4_DICDI 2.00E-29 GO:0005524; GO:0003677; GO:0003910; GO:0032807; GO:0006310; GO:0005958; GO:0005694; GO:0006303; GO:0006273; GO:0046872; GO:0006289; GO:0000012 ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligase IV complex; DNA recombination; DNA-dependent protein kinase-DNA ligase 4 complex; chromosome; double-strand break repair via nonhomologous end joining; lagging strand elongation; metal ion binding; nucleotide-excision repair; single strand break repair IPR001357; IPR000977; IPR012309; IPR012310; IPR012308; IPR021536; IPR012340; DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) lig4 DDB_G0292760 Dictyostelium discoideum (Slime mold) TR31326_c3_g1_i1 P12000 DNLI1_SCHPO 5.00E-17 GO:0005524; GO:0003677; GO:0003910; GO:0051103; GO:0006310; GO:0043137; GO:0006284; GO:0007049; GO:0051301; GO:0046872; GO:0005739; GO:0043596; GO:0006289; GO:0000723 "ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligation involved in DNA repair; DNA recombination; DNA replication, removal of RNA primer; base-excision repair; cell cycle; cell division; metal ion binding; mitochondrion; nuclear replication fork; nucleotide-excision repair; telomere maintenance" IPR000977; IPR012309; IPR012310; IPR016059; IPR012308; IPR012340; DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) cdc17 SPAC20G8.01 SPAC57A10.13c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR31326_c3_g2_i1 Q90YB1 DNLI4_CHICK 4.00E-61 GO:0005524; GO:0003677; GO:0003910; GO:0032807; GO:0051103; GO:0033151; GO:0007049; GO:0051301; GO:0005694; GO:0006303; GO:0006273; GO:0046872; GO:0070419; GO:0005654; GO:0006289 ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligase IV complex; DNA ligation involved in DNA repair; V(D)J recombination; cell cycle; cell division; chromosome; double-strand break repair via nonhomologous end joining; lagging strand elongation; metal ion binding; nonhomologous end joining complex; nucleoplasm; nucleotide-excision repair IPR001357; IPR000977; IPR012309; IPR012310; IPR016059; IPR012308; IPR021536; IPR012340; DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) LIG4 RCJMB04_10b2 Gallus gallus (Chicken) TR31330_c0_g1_i2 Q09621 LACT2_CAEEL 2.00E-48 GO:0016021 integral to membrane IPR001466; IPR012338; Beta-lactamase domain-containing protein 2 lact-2 ZK945.1 Caenorhabditis elegans TR31331_c0_g1_i1 A6QQF5 QORL2_BOVIN 4.00E-07 GO:0005739; GO:0016491; GO:0008270 mitochondrion; oxidoreductase activity; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; Quinone oxidoreductase-like protein 2 (EC 1.-.-.-) Bos taurus (Bovine) TR31331_c1_g1_i1 P12785 FAS_RAT 2.00E-137 GO:0047451; GO:0004317; GO:0004316; GO:0004315; GO:0005794; GO:0070402; GO:0004313; GO:0004314; GO:0006084; GO:0071353; GO:0008144; GO:0047117; GO:0004319; GO:0006633; GO:0004312; GO:0042587; GO:0042470; GO:0005739; GO:0016295; GO:0004320; GO:0016296; GO:0005886; GO:0042803; GO:0008270 Itself "3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; Golgi apparatus; NADPH binding; [acyl-carrier-protein] S-acetyltransferase activity; [acyl-carrier-protein] S-malonyltransferase activity; acetyl-CoA metabolic process; cellular response to interleukin-4; drug binding; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; fatty acid biosynthetic process; fatty acid synthase activity; glycogen granule; melanosome; mitochondrion; myristoyl-[acyl-carrier-protein] hydrolase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; plasma membrane; protein homodimerization activity; zinc ion binding" IPR001227; IPR009081; IPR014043; IPR016035; IPR013149; IPR023102; IPR011032; IPR018201; IPR014031; IPR014030; IPR016036; IPR013217; IPR016040; IPR020842; IPR020843; IPR013968; IPR006162; IPR001031; IPR016039; IPR016038; Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] Fasn Rattus norvegicus (Rat) TR31331_c1_g1_i2 P19096 FAS_MOUSE 6.00E-116 GO:0047451; GO:0004317; GO:0004316; GO:0004315; GO:0005794; GO:0004313; GO:0004314; GO:0071353; GO:0047117; GO:0004319; GO:0006633; GO:0042587; GO:0042470; GO:0005739; GO:0016295; GO:0004320; GO:0016296; GO:0005886; GO:0008270 "3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; Golgi apparatus; [acyl-carrier-protein] S-acetyltransferase activity; [acyl-carrier-protein] S-malonyltransferase activity; cellular response to interleukin-4; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; fatty acid biosynthetic process; glycogen granule; melanosome; mitochondrion; myristoyl-[acyl-carrier-protein] hydrolase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; plasma membrane; zinc ion binding" IPR001227; IPR009081; IPR014043; IPR016035; IPR013149; IPR023102; IPR011032; IPR018201; IPR014031; IPR014030; IPR016036; IPR013217; IPR016040; IPR020842; IPR020843; IPR013968; IPR006162; IPR001031; IPR016039; IPR016038; Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] Fasn Mus musculus (Mouse) TR31332_c0_g2_i2 P50426 GNS_CAPHI 3.00E-149 GO:0008449; GO:0030203; GO:0005764; GO:0046872 N-acetylglucosamine-6-sulfatase activity; glycosaminoglycan metabolic process; lysosome; metal ion binding IPR017849; IPR017850; IPR012251; IPR015981; IPR000917; IPR024607; N-acetylglucosamine-6-sulfatase (EC 3.1.6.14) (Glucosamine-6-sulfatase) (G6S) GNS Capra hircus (Goat) TR31333_c0_g1_i1 Q9UIJ7 KAD3_HUMAN 1.00E-88 GO:0046033; GO:0005524; GO:0005525; GO:0046039; GO:0046041; GO:0046051; GO:0007596; GO:0005759; GO:0046899; GO:0019201 AMP metabolic process; ATP binding; GTP binding; GTP metabolic process; ITP metabolic process; UTP metabolic process; blood coagulation; mitochondrial matrix; nucleoside triphosphate adenylate kinase activity; nucleotide kinase activity IPR006259; IPR000850; IPR007862; IPR027417; "GTP:AMP phosphotransferase AK3, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (AK 3) (Adenylate kinase 3 alpha-like 1)" AK3 AK3L1 AK6 AKL3L Homo sapiens (Human) TR31333_c0_g1_i2 Q9WTP7 KAD3_MOUSE 4.00E-89 GO:0046033; GO:0005524; GO:0005525; GO:0046039; GO:0046041; GO:0046051; GO:0004017; GO:0005759; GO:0046899 AMP metabolic process; ATP binding; GTP binding; GTP metabolic process; ITP metabolic process; UTP metabolic process; adenylate kinase activity; mitochondrial matrix; nucleoside triphosphate adenylate kinase activity IPR006259; IPR000850; IPR007862; IPR027417; "GTP:AMP phosphotransferase AK3, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (AK 3) (Adenylate kinase 3 alpha-like 1)" Ak3 Ak3l Ak3l1 Akl3l Mus musculus (Mouse) TR31335_c0_g2_i1 P54369 OAZ1_MOUSE 5.00E-32 GO:0008073; GO:0006595 ornithine decarboxylase inhibitor activity; polyamine metabolic process IPR016181; IPR002993; Ornithine decarboxylase antizyme 1 (ODC-Az) Oaz1 Oaz Mus musculus (Mouse) TR31336_c0_g1_i1 Q8C0Y1 TGIF2_MOUSE 3.00E-35 GO:0038092; GO:0005634; GO:0045666; GO:0010470; GO:0060041; GO:0043565; GO:0003700; GO:0006351 "nodal signaling pathway; nucleus; positive regulation of neuron differentiation; regulation of gastrulation; retina development in camera-type eye; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001356; IPR008422; IPR009057; Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2) Tgif2 Mus musculus (Mouse) TR31339_c0_g2_i1 Q24157 BRN_DROME 1.00E-38 GO:0000139; GO:0005795; GO:0007219; GO:0046981; GO:0007298; GO:0005576; GO:0047915; GO:0007293; GO:0006688; GO:0008314; GO:0016021; GO:0042248; GO:0001744; GO:0007299; GO:0006486 "Golgi membrane; Golgi stack; Notch signaling pathway; beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity; border follicle cell migration; extracellular region; ganglioside galactosyltransferase activity; germarium-derived egg chamber formation; glycosphingolipid biosynthetic process; gurken receptor signaling pathway; integral to membrane; maintenance of polarity of follicular epithelium; optic lobe placode formation; ovarian follicle cell-cell adhesion; protein glycosylation" IPR002659; "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) TR31340_c1_g1_i2 O02654 ENO_LOLPE 0 GO:0006096; GO:0000287; GO:0004634; GO:0000015 glycolysis; magnesium ion binding; phosphopyruvate hydratase activity; phosphopyruvate hydratase complex IPR000941; IPR020810; IPR020809; IPR020811; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5. Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR31340_c1_g2_i1 O30885 ENO_CAMFE 2.00E-42 GO:0009986; GO:0005576; GO:0006096; GO:0000287; GO:0004634; GO:0000015 cell surface; extracellular region; glycolysis; magnesium ion binding; phosphopyruvate hydratase activity; phosphopyruvate hydratase complex IPR000941; IPR020810; IPR020811; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5. Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) (Fragment) eno Campylobacter fetus TR31341_c3_g1_i1 Q9VH14 TIMP_DROME 1.00E-18 GO:0071711; GO:0007155; GO:0060232; GO:0030425; GO:0005576; GO:0048526; GO:0046872; GO:0008191; GO:0042331; GO:0007426; GO:0035202 "basement membrane organization; cell adhesion; delamination; dendrite; extracellular region; imaginal disc-derived wing expansion; metal ion binding; metalloendopeptidase inhibitor activity; phototaxis; tracheal outgrowth, open tracheal system; tracheal pit formation in open tracheal system" IPR001134; IPR001820; IPR008993; IPR027465; Tissue inhibitor of metalloproteases Timp CG6281 Drosophila melanogaster (Fruit fly) TR31341_c3_g1_i3 Q9VH14 TIMP_DROME 1.00E-19 GO:0071711; GO:0007155; GO:0060232; GO:0030425; GO:0005576; GO:0048526; GO:0046872; GO:0008191; GO:0042331; GO:0007426; GO:0035202 "basement membrane organization; cell adhesion; delamination; dendrite; extracellular region; imaginal disc-derived wing expansion; metal ion binding; metalloendopeptidase inhibitor activity; phototaxis; tracheal outgrowth, open tracheal system; tracheal pit formation in open tracheal system" IPR001134; IPR001820; IPR008993; IPR027465; Tissue inhibitor of metalloproteases Timp CG6281 Drosophila melanogaster (Fruit fly) TR31342_c0_g1_i1 O96064 MYSP_MYTGA 0 GO:0003774; GO:0030016; GO:0032982 motor activity; myofibril; myosin filament IPR015650; IPR002928; Paramyosin Mytilus galloprovincialis (Mediterranean mussel) TR31342_c0_g2_i1 P04460 MYH6_RABIT 2.00E-17 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR027401; IPR002928; "Myosin-6 (Alpha isomyosin) (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) (Fragment)" MYH6 Oryctolagus cuniculus (Rabbit) TR31347_c0_g1_i1 Q90964 FOXG1_CHICK 4.00E-61 GO:0007275; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; Forkhead box protein G1 (FoxG1) (Brain factor 1) (BF-1) (BF1) (cBF-1) (CEQ 3-1) (Forkhead-related protein FKHL1) (N-62-5) (Proto-oncogene C-QIN) FOXG1 FKHL1 FOXG1B QIN Gallus gallus (Chicken) TR31348_c0_g1_i1 P05786 K2C8_BOVIN 4.00E-12 GO:0005737; GO:0045095; GO:0016363; GO:0005654; GO:0005198 cytoplasm; keratin filament; nuclear matrix; nucleoplasm; structural molecule activity IPR001664; IPR018039; IPR003054; "Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Cytokeratin-A) (Keratin-8) (K8) (Type-II keratin Kb8)" KRT8 Bos taurus (Bovine) TR31348_c0_g1_i2 P22488 IFEA_HELAS 1.00E-132 GO:0005737; GO:0005882; GO:0005198 cytoplasm; intermediate filament; structural molecule activity IPR001664; IPR016451; IPR018039; Non-neuronal cytoplasmic intermediate filament protein (IF) Helix aspersa (Brown garden snail) (Cornu aspersum) TR31351_c7_g2_i1 O55012 PICA_RAT 2.00E-159 GO:0005545; GO:0005794; GO:0017124; GO:0007409; GO:0030276; GO:0030118; GO:0048268; GO:0005905; GO:0048813; GO:0005768; GO:0097481; GO:0005634; GO:0045211; GO:0042734; GO:0006898; GO:0030100; GO:0051223; GO:0008021 Itself; P63027; Q15836; O70404 1-phosphatidylinositol binding; Golgi apparatus; SH3 domain binding; axonogenesis; clathrin binding; clathrin coat; clathrin coat assembly; coated pit; dendrite morphogenesis; endosome; neuronal postsynaptic density; nucleus; postsynaptic membrane; presynaptic membrane; receptor-mediated endocytosis; regulation of endocytosis; regulation of protein transport; synaptic vesicle IPR011417; IPR014712; IPR008942; IPR013809; Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) (rCALM) Picalm Calm Rattus norvegicus (Rat) TR31351_c7_g2_i4 Q9VI75 PICA_DROME 5.00E-164 GO:0005545; GO:0005794; GO:0030276; GO:0030118; GO:0048268; GO:0005905; GO:0007270; GO:0007269; GO:0042331; GO:0006898; GO:0008021; GO:0016183 1-phosphatidylinositol binding; Golgi apparatus; clathrin binding; clathrin coat; clathrin coat assembly; coated pit; neuron-neuron synaptic transmission; neurotransmitter secretion; phototaxis; receptor-mediated endocytosis; synaptic vesicle; synaptic vesicle coating IPR011417; IPR014712; IPR008942; IPR013809; Phosphatidylinositol-binding clathrin assembly protein LAP (Like-AP180) lap CG2520 Drosophila melanogaster (Fruit fly) TR31353_c0_g2_i1 P57784 RU2A_MOUSE 1.00E-112 GO:0003723; GO:0008380; GO:0071013; GO:0006397 RNA binding; RNA splicing; catalytic step 2 spliceosome; mRNA processing IPR001611; IPR003603; U2 small nuclear ribonucleoprotein A' (U2 snRNP A') Snrpa1 Mus musculus (Mouse) TR31355_c0_g1_i1 Q6QLW4 CYC_PECGU 2.00E-60 GO:0009055; GO:0020037; GO:0005506; GO:0005758; GO:0055114; GO:0070469 electron carrier activity; heme binding; iron ion binding; mitochondrial intermembrane space; oxidation-reduction process; respiratory chain IPR009056; IPR002327; IPR003088; Cytochrome c Pectinaria gouldii (Trumpet worm) (Ice-cream cone worm) TR31356_c0_g1_i1 Q2TB18 ASTE1_HUMAN 5.00E-46 GO:0006281; GO:0004518; GO:0090305 DNA repair; nuclease activity; nucleic acid phosphodiester bond hydrolysis IPR026832; IPR006085; Protein asteroid homolog 1 ASTE1 HT001 Homo sapiens (Human) TR31361_c0_g1_i2 Q9VZW5 FMAR_DROME 2.00E-07 GO:0002209; GO:0007204; GO:0005887; GO:0008345; GO:0008188 behavioral defense response; elevation of cytosolic calcium ion concentration; integral to plasma membrane; larval locomotory behavior; neuropeptide receptor activity IPR000276; IPR017452; FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) TR31364_c0_g1_i2 P18101 RL40_DROME 1.00E-87 GO:0006464; GO:0022625; GO:0005875; GO:0005634; GO:0003735; GO:0006412; GO:0006511 cellular protein modification process; cytosolic large ribosomal subunit; microtubule associated complex; nucleus; structural constituent of ribosome; translation; ubiquitin-dependent protein catabolic process IPR001975; IPR019956; IPR019954; IPR000626; Ubiquitin-60S ribosomal protein L40 (CEP52) [Cleaved into: Ubiquitin; 60S ribosomal protein L40] RpL40 Ubi-f UBI-F52 CG2960 Drosophila melanogaster (Fruit fly) TR31365_c0_g1_i1 A4IGU3 MT21A_XENTR 3.00E-43 GO:0005737; GO:0016279 cytoplasm; protein-lysine N-methyltransferase activity IPR019410; Protein N-lysine methyltransferase METTL21A (EC 2.1.1.-) (Methyltransferase-like protein 21A) mettl21a Fam119a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31369_c0_g1_i2 O73888 HPGDS_CHICK 2.00E-41 GO:0005509; GO:0005737; GO:0004364; GO:0000287; GO:0005634; GO:0001516; GO:0006693; GO:0004667 calcium ion binding; cytoplasm; glutathione transferase activity; magnesium ion binding; nucleus; prostaglandin biosynthetic process; prostaglandin metabolic process; prostaglandin-D synthase activity IPR010987; IPR004045; IPR004046; IPR012336; Hematopoietic prostaglandin D synthase (H-PGDS) (EC 5.3.99.2) (GST class-sigma) (Glutathione S-transferase) (EC 2.5.1.18) (Glutathione-dependent PGD synthase) (Glutathione-requiring prostaglandin D synthase) (Prostaglandin-H2 D-isomerase) HPGDS GSTS PGDS PTGDS2 Gallus gallus (Chicken) TR31373_c2_g1_i1 Q99LJ0 CT2NL_MOUSE 8.00E-47 GO:0015629; GO:0005737 actin cytoskeleton; cytoplasm IPR019131; CTTNBP2 N-terminal-like protein Cttnbp2nl Kiaa1433 Mus musculus (Mouse) TR31373_c3_g1_i1 Q9Y5Y6 ST14_HUMAN 6.00E-11 GO:0005576; GO:0019897; GO:0005887; GO:0006508; GO:0004252; GO:0008236 extracellular region; extrinsic to plasma membrane; integral to plasma membrane; proteolysis; serine-type endopeptidase activity; serine-type peptidase activity IPR000859; IPR023415; IPR002172; IPR001254; IPR018114; IPR017051; IPR000082; IPR009003; Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein) ST14 PRSS14 SNC19 TADG15 Homo sapiens (Human) TR31373_c5_g1_i1 Q07DZ5 CTTB2_ORNAN 2.00E-08 GO:0005938; GO:0043197 cell cortex; dendritic spine IPR002110; IPR020683; IPR019131; Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Ornithorhynchus anatinus (Duckbill platypus) TR31373_c6_g1_i1 Q54HW1 PSD10_DICDI 4.00E-10 IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) psmD10 DDB_G0289189 Dictyostelium discoideum (Slime mold) TR31377_c0_g1_i2 A6QPI6 TOM22_BOVIN 9.00E-07 GO:0016021; GO:0005743; GO:0005742; GO:0045040 integral to membrane; mitochondrial inner membrane; mitochondrial outer membrane translocase complex; protein import into mitochondrial outer membrane IPR005683; Mitochondrial import receptor subunit TOM22 homolog (Translocase of outer membrane 22 kDa subunit homolog) TOMM22 Bos taurus (Bovine) TR3138_c0_g1_i1 P04927 SANT_PLAFF 9.00E-17 GO:0020003 symbiont-containing vacuole IPR008825; S-antigen protein Plasmodium falciparum (isolate FC27 / Papua New Guinea) TR31382_c8_g3_i1 Q63HN8 RN213_HUMAN 3.00E-33 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR018957; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) TR31382_c8_g3_i2 E9Q555 RN213_MOUSE 4.00E-34 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) Rnf213 Mus musculus (Mouse) TR31382_c9_g1_i1 Q63HN8 RN213_HUMAN 1.00E-09 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR018957; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) TR31383_c0_g1_i1 Q96L03 SPT17_HUMAN 2.00E-67 GO:0005737 cytoplasm IPR000048; IPR027417; Spermatogenesis-associated protein 17 SPATA17 Homo sapiens (Human) TR31384_c1_g1_i1 Q21166 SUR5_CAEEL 3.00E-86 GO:0005524; GO:0030729; GO:0005737; GO:0006631; GO:0005634 ATP binding; acetoacetate-CoA ligase activity; cytoplasm; fatty acid metabolic process; nucleus IPR005914; IPR025110; IPR020845; IPR000873; Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Suppressor of activated let-60 Ras protein 5) sur-5 K03A1.5 Caenorhabditis elegans TR31384_c2_g1_i1 Q5ZLG0 AACS_CHICK 8.00E-159 GO:0005524; GO:0030729; GO:0005829; GO:0006631 ATP binding; acetoacetate-CoA ligase activity; cytosol; fatty acid metabolic process IPR005914; IPR020845; IPR000873; Acetoacetyl-CoA synthetase (EC 6.2.1.16) AACS RCJMB04_6g9 Gallus gallus (Chicken) TR31387_c0_g1_i2 Q9DG23 POPD1_CHICK 2.00E-46 GO:0090136; GO:0016021; GO:0016328; GO:0007275; GO:0040017; GO:0001921; GO:0043088; GO:0032314; GO:0008360; GO:0005198; GO:0034446; GO:0005923; GO:0016192 epithelial cell-cell adhesion; integral to membrane; lateral plasma membrane; multicellular organismal development; positive regulation of locomotion; positive regulation of receptor recycling; regulation of Cdc42 GTPase activity; regulation of Rac GTPase activity; regulation of cell shape; structural molecule activity; substrate adhesion-dependent cell spreading; tight junction; vesicle-mediated transport IPR018490; IPR006916; Blood vessel epicardial substance (Popeye domain-containing protein 1) (Popeye protein 1) BVES POP1 POPDC1 Gallus gallus (Chicken) TR31391_c10_g1_i2 Q460N5 PAR14_HUMAN 3.00E-33 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR31391_c10_g1_i3 Q9H0J9 PAR12_HUMAN 5.00E-08 GO:0003950; GO:0046872; GO:0005634 NAD+ ADP-ribosyltransferase activity; metal ion binding; nucleus IPR012317; IPR004170; IPR000571; Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) TR31392_c3_g3_i1 Q4R7D5 F227B_MACFA 4.00E-20 Protein FAM227B FAM227B QtsA-15558 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR31393_c3_g1_i1 Q0IIH7 ST14_BOVIN 6.00E-13 GO:0016021; GO:0006508; GO:0004252 integral to membrane; proteolysis; serine-type endopeptidase activity IPR000859; IPR023415; IPR002172; IPR001254; IPR018114; IPR017051; IPR000082; IPR009003; Suppressor of tumorigenicity 14 protein homolog (EC 3.4.21.109) (Serine protease 14) ST14 PRSS14 Bos taurus (Bovine) TR31393_c6_g1_i1 P98165 VLDLR_CHICK 3.00E-27 GO:0005509; GO:0008203; GO:0005905; GO:0016021; GO:0006869; GO:0030228; GO:0021517; GO:0034361 calcium ion binding; cholesterol metabolic process; coated pit; integral to membrane; lipid transport; lipoprotein particle receptor activity; ventral spinal cord development; very-low-density lipoprotein particle IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023415; IPR000033; IPR002172; Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) (Vitellogenin receptor) (VTG receptor) VLDLR VTGR Gallus gallus (Chicken) TR31393_c6_g2_i1 O75074 LRP3_HUMAN 3.00E-06 GO:0005905; GO:0016021; GO:0006898 coated pit; integral to membrane; receptor-mediated endocytosis IPR000859; IPR023415; IPR002172; Low-density lipoprotein receptor-related protein 3 (LRP-3) (105 kDa low-density lipoprotein receptor-related protein) (hLRp105) LRP3 Homo sapiens (Human) TR31393_c7_g1_i1 Q04833 LRP_CAEEL 4.00E-28 GO:0016324; GO:0005509; GO:0005905; GO:0042395; GO:0030139; GO:0006897; GO:0016021; GO:0002119; GO:0040017; GO:0040018; GO:0030334; GO:0015248 "apical plasma membrane; calcium ion binding; coated pit; ecdysis, collagen and cuticulin-based cuticle; endocytic vesicle; endocytosis; integral to membrane; nematode larval development; positive regulation of locomotion; positive regulation of multicellular organism growth; regulation of cell migration; sterol transporter activity" IPR011042; IPR000742; IPR001881; IPR013032; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein (LRP) lrp-1 F29D11.1 Caenorhabditis elegans TR31393_c9_g2_i4 P98159 NUDEL_DROME 2.00E-08 GO:0008063; GO:0007343; GO:0007306; GO:0007313; GO:0016485; GO:0005578; GO:0006508; GO:0004252 "Toll signaling pathway; egg activation; eggshell chorion assembly; maternal specification of dorsal/ventral axis, oocyte, soma encoded; protein processing; proteinaceous extracellular matrix; proteolysis; serine-type endopeptidase activity" IPR023415; IPR002172; IPR001254; IPR018114; IPR015420; IPR009003; Serine protease nudel (EC 3.4.21.-) ndl CG10129 Drosophila melanogaster (Fruit fly) TR31394_c0_g1_i1 Q6AYU1 MO4L1_RAT 4.00E-80 GO:0035267; GO:0016580; GO:0008283; GO:0003682; GO:0000724; GO:0043968; GO:0043967; GO:0016575; GO:0040008; GO:0006355; GO:0006351 "NuA4 histone acetyltransferase complex; Sin3 complex; cell proliferation; chromatin binding; double-strand break repair via homologous recombination; histone H2A acetylation; histone H4 acetylation; histone deacetylation; regulation of growth; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000953; IPR016197; IPR017398; IPR008676; IPR026541; IPR025995; Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (Transcription factor-like protein MRG15) Morf4l1 Rattus norvegicus (Rat) TR31394_c0_g3_i1 Q5R6Y9 MS3L1_PONAB 2.00E-11 GO:0003677; GO:0072487; GO:0043984; GO:0035064; GO:0006355; GO:0006351 "DNA binding; MSL complex; histone H4-K16 acetylation; methylated histone residue binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000953; IPR016197; IPR008676; IPR026541; IPR025995; Male-specific lethal 3 homolog (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) MSL3 MSL3L1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR31398_c0_g4_i1 Q6TLE4 MMGT1_DANRE 1.00E-16 GO:0072546; GO:0005794; GO:0000139; GO:0005769; GO:0031901; GO:0015095 ER membrane protein complex; Golgi apparatus; Golgi membrane; early endosome; early endosome membrane; magnesium ion transmembrane transporter activity IPR018937; Membrane magnesium transporter 1 (ER membrane protein complex subunit 5) (Transmembrane protein 32) mmgt1 emc5 tmem32 zgc:92918 Danio rerio (Zebrafish) (Brachydanio rerio) TR31401_c1_g1_i1 Q5RK30 SBDS_RAT 2.00E-115 GO:0003723; GO:0008283; GO:0005737; GO:0042256; GO:0005730; GO:0005654; GO:0005634; GO:0006364; GO:0042273; GO:0043022; GO:0000922 RNA binding; cell proliferation; cytoplasm; mature ribosome assembly; nucleolus; nucleoplasm; nucleus; rRNA processing; ribosomal large subunit biogenesis; ribosome binding; spindle pole IPR018978; IPR018023; IPR019783; IPR002140; Ribosome maturation protein SBDS (Shwachman-Bodian-Diamond syndrome protein homolog) Sbds Rattus norvegicus (Rat) TR31401_c1_g1_i2 Q07953 SDO1_YEAST 3.00E-46 GO:0005737; GO:0005085; GO:0042256; GO:0005634 Itself; P39940; P02994 cytoplasm; guanyl-nucleotide exchange factor activity; mature ribosome assembly; nucleus IPR018978; IPR018023; IPR019783; IPR002140; Ribosome maturation protein SDO1 SDO1 YLR022C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR31404_c2_g1_i1 Q15075 EEA1_HUMAN 3.00E-10 GO:0005545; GO:0030742; GO:0005516; GO:0005829; GO:0005769; GO:0031901; GO:0045022; GO:0019897; GO:0042803; GO:0055037; GO:0005969; GO:0016189; GO:0006906; GO:0008270 P04626; Q9UL26; P20339; P61020; Q63635 1-phosphatidylinositol binding; GTP-dependent protein binding; calmodulin binding; cytosol; early endosome; early endosome membrane; early endosome to late endosome transport; extrinsic to plasma membrane; protein homodimerization activity; recycling endosome; serine-pyruvate aminotransferase complex; synaptic vesicle to endosome fusion; vesicle fusion; zinc ion binding IPR007087; IPR015880; IPR000306; IPR017455; IPR011011; IPR013083; Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) EEA1 ZFYVE2 Homo sapiens (Human) TR31407_c0_g1_i1 Q7T0X7 OXND1_XENLA 4.00E-70 GO:0016491 oxidoreductase activity IPR017927; IPR001433; IPR001221; IPR017938; Oxidoreductase NAD-binding domain-containing protein 1 (EC 1.-.-.-) oxnad1 Xenopus laevis (African clawed frog) TR3141_c0_g1_i1 P14629 ERCC5_XENLA 1.00E-38 GO:0004519; GO:0046872; GO:0090305; GO:0006289; GO:0005634; GO:0003697 endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleotide-excision repair; nucleus; single-stranded DNA binding IPR020045; IPR008918; IPR006086; IPR006084; IPR001044; IPR019974; IPR006085; DNA repair protein complementing XP-G cells homolog (EC 3.1.-.-) (Xeroderma pigmentosum group G-complementing protein homolog) ercc5 xpg xpgc Xenopus laevis (African clawed frog) TR31410_c0_g1_i1 Q23424 FZO1_CAEEL 9.00E-26 GO:0005525; GO:0003924; GO:0016021; GO:0008053; GO:0005741 GTP binding; GTPase activity; integral to membrane; mitochondrial fusion; mitochondrial outer membrane IPR001401; IPR006884; IPR027091; IPR027094; IPR027417; Transmembrane GTPase fzo-1 (EC 3.6.5.-) fzo-1 ZK1248.14 Caenorhabditis elegans TR31410_c0_g1_i2 Q7YU24 MARF_DROME 3.00E-40 GO:0005525; GO:0003924; GO:0016021; GO:0005740; GO:0008053; GO:0005741; GO:0010636 GTP binding; GTPase activity; integral to membrane; mitochondrial envelope; mitochondrial fusion; mitochondrial outer membrane; positive regulation of mitochondrial fusion IPR001401; IPR006884; IPR027091; IPR027094; IPR027417; Transmembrane GTPase Marf (EC 3.6.5.-) (Mitochondrial assembly regulatory factor) (Mitofusin) Marf dmfn CG3869 Drosophila melanogaster (Fruit fly) TR31412_c0_g2_i2 Q9Z160 COG1_MOUSE 0 GO:0000139; GO:0015031 Golgi membrane; protein transport Conserved oligomeric Golgi complex subunit 1 (COG complex subunit 1) (Component of oligomeric Golgi complex 1) (Low density lipoprotein receptor defect B-complementing protein) Cog1 Ldlb Mus musculus (Mouse) TR31413_c0_g1_i1 Q6DEF4 LYSM2_DANRE 3.00E-15 GO:0016998 cell wall macromolecule catabolic process IPR018392; LysM and putative peptidoglycan-binding domain-containing protein 2 lysmd2 si:ch211-12a1.4 zgc:91941 Danio rerio (Zebrafish) (Brachydanio rerio) TR31415_c0_g1_i2 Q8R015 MUTED_MOUSE 6.00E-22 GO:0031083; GO:0008089; GO:0048490; GO:0035646; GO:0032402; GO:0031175; GO:0032474; GO:0050942; GO:0030133 BLOC-1 complex; anterograde axon cargo transport; anterograde synaptic vesicle transport; endosome to melanosome transport; melanosome transport; neuron projection development; otolith morphogenesis; positive regulation of pigment cell differentiation; transport vesicle IPR017243; Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC-1 subunit 5) (Protein Muted homolog) Bloc1s5 Mu Muted Mus musculus (Mouse) TR31416_c2_g1_i1 Q8IUC8 GLT13_HUMAN 2.00E-77 GO:0000139; GO:0016266; GO:0016021; GO:0004653; GO:0043687 Golgi membrane; O-glycan processing; integral to membrane; polypeptide N-acetylgalactosaminyltransferase activity; post-translational protein modification IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 13 (EC 2.4.1.41) (Polypeptide GalNAc transferase 13) (GalNAc-T13) (pp-GaNTase 13) (Protein-UDP acetylgalactosaminyltransferase 13) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13) GALNT13 KIAA1918 Homo sapiens (Human) TR31416_c2_g2_i1 Q9U2C4 GALT9_CAEEL 2.00E-82 GO:0000139; GO:0016021; GO:0006486; GO:0016757 "Golgi membrane; integral to membrane; protein glycosylation; transferase activity, transferring glycosyl groups" IPR001173; IPR000772; Protein modification; protein glycosylation. Probable N-acetylgalactosaminyltransferase 9 (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase 9) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 9) (pp-GaNTase 9) gly-9 Y47D3A.23 Caenorhabditis elegans TR31417_c0_g1_i1 Q32KV4 DC2L1_BOVIN 5.00E-114 GO:0045177; GO:0042384; GO:0035085; GO:0007368; GO:0030286; GO:0030990; GO:0005874; GO:0031512; GO:0003774 apical part of cell; cilium assembly; cilium axoneme; determination of left/right symmetry; dynein complex; intraflagellar transport particle; microtubule; motile primary cilium; motor activity IPR022780; IPR027417; Cytoplasmic dynein 2 light intermediate chain 1 DYNC2LI1 Bos taurus (Bovine) TR31418_c0_g1_i1 Q60636 PRDM1_MOUSE 3.00E-53 GO:0003677; GO:0045165; GO:0005737; GO:0042462; GO:0007281; GO:0042826; GO:0001893; GO:0046872; GO:0008168; GO:0007275; GO:0030889; GO:0031665; GO:0000122; GO:0005634; GO:0045579; GO:0010628; GO:0006355; GO:0043565; GO:0006351; GO:0060707 P63165 "DNA binding; cell fate commitment; cytoplasm; eye photoreceptor cell development; germ cell development; histone deacetylase binding; maternal placenta development; metal ion binding; methyltransferase activity; multicellular organismal development; negative regulation of B cell proliferation; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of B cell differentiation; positive regulation of gene expression; regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription, DNA-dependent; trophoblast giant cell differentiation" IPR001214; IPR007087; IPR015880; IPR013087; IPR016608; PR domain zinc finger protein 1 (EC 2.1.1.-) (B lymphocyte-induced maturation protein 1) (Blimp-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) Prdm1 Blimp1 Mus musculus (Mouse) TR31418_c5_g1_i1 Q60636 PRDM1_MOUSE 1.00E-14 GO:0003677; GO:0045165; GO:0005737; GO:0042462; GO:0007281; GO:0042826; GO:0001893; GO:0046872; GO:0008168; GO:0007275; GO:0030889; GO:0031665; GO:0000122; GO:0005634; GO:0045579; GO:0010628; GO:0006355; GO:0043565; GO:0006351; GO:0060707 P63165 "DNA binding; cell fate commitment; cytoplasm; eye photoreceptor cell development; germ cell development; histone deacetylase binding; maternal placenta development; metal ion binding; methyltransferase activity; multicellular organismal development; negative regulation of B cell proliferation; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of B cell differentiation; positive regulation of gene expression; regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription, DNA-dependent; trophoblast giant cell differentiation" IPR001214; IPR007087; IPR015880; IPR013087; IPR016608; PR domain zinc finger protein 1 (EC 2.1.1.-) (B lymphocyte-induced maturation protein 1) (Blimp-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) Prdm1 Blimp1 Mus musculus (Mouse) TR31419_c7_g3_i1 Q13489 BIRC3_HUMAN 4.00E-19 GO:0038061; GO:0035666; GO:0006915; GO:0007166; GO:0005829; GO:0045087; GO:0070266; GO:0043066; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0043123; GO:0039535; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0034138; GO:0034142; GO:0004842; GO:0008270 Q13546; O43353; Q9Y572; P57078; Q12933 NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; apoptotic process; cell surface receptor signaling pathway; cytosol; innate immune response; necroptosis; negative regulation of apoptotic process; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of RIG-I signaling pathway; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Apoptosis inhibitor 2) (API2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (IAP-1) (hIAP-1) (hIAP1) (RING finger protein 49) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 IAP1 MIHC RNF49 Homo sapiens (Human) TR31421_c1_g1_i1 P38620 KPR2_YEAST 4.00E-37 GO:0006015; GO:0005524; GO:0005737; GO:0031505; GO:0016301; GO:0000287; GO:0009165; GO:0009156; GO:0004749 P32895; Q12265 5-phosphoribose 1-diphosphate biosynthetic process; ATP binding; cytoplasm; fungal-type cell wall organization; kinase activity; magnesium ion binding; nucleotide biosynthetic process; ribonucleoside monophosphate biosynthetic process; ribose phosphate diphosphokinase activity IPR000842; IPR005946; Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 2) PRS2 PRPS2 PRS YER099C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR31421_c2_g1_i1 Q9EWS0 KPRH_STRCO 3.00E-11 GO:0005524; GO:0005737; GO:0016301; GO:0000287; GO:0009165; GO:0009156; GO:0004749 ATP binding; cytoplasm; kinase activity; magnesium ion binding; nucleotide biosynthetic process; ribonucleoside monophosphate biosynthetic process; ribose phosphate diphosphokinase activity IPR005946; Putative ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) SCO0782 3SCF60.14c Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) TR31421_c2_g1_i2 Q14558 KPRA_HUMAN 5.00E-115 GO:0004857; GO:0000287; GO:0033673; GO:0006139; GO:0009165; GO:0004749; GO:0002189 enzyme inhibitor activity; magnesium ion binding; negative regulation of kinase activity; nucleobase-containing compound metabolic process; nucleotide biosynthetic process; ribose phosphate diphosphokinase activity; ribose phosphate diphosphokinase complex IPR005946; Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39) PRPSAP1 Homo sapiens (Human) TR31423_c10_g1_i1 Q6C3K2 ALG1_YARLI 1.00E-36 GO:0004578; GO:0005789; GO:0016021; GO:0006486 chitobiosyldiphosphodolichol beta-mannosyltransferase activity; endoplasmic reticulum membrane; integral to membrane; protein glycosylation IPR026051; Protein modification; protein glycosylation. "Chitobiosyldiphosphodolichol beta-mannosyltransferase (EC 2.4.1.142) (Asparagine-linked glycosylation protein 1) (Beta-1,4-mannosyltransferase) (GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase) (GDP-mannose-dolichol diphosphochitobiose mannosyltransferase)" ALG1 YALI0E34133g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR31423_c10_g2_i1 Q921Q3 ALG1_MOUSE 4.00E-75 GO:0004578; GO:0005789; GO:0016021; GO:0006486 chitobiosyldiphosphodolichol beta-mannosyltransferase activity; endoplasmic reticulum membrane; integral to membrane; protein glycosylation IPR026051; Protein modification; protein glycosylation. "Chitobiosyldiphosphodolichol beta-mannosyltransferase (EC 2.4.1.142) (Asparagine-linked glycosylation protein 1 homolog) (Beta-1,4-mannosyltransferase) (GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase) (GDP-mannose-dolichol diphosphochitobiose mannosyltransferase)" Alg1 Mus musculus (Mouse) TR31426_c0_g1_i2 Q640B4 MUS81_XENTR 2.00E-95 GO:0003677; GO:0006310; GO:0006281; GO:0004519; GO:0046872; GO:0090305; GO:0005634 DNA binding; DNA recombination; DNA repair; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleus IPR010996; IPR020819; IPR006166; IPR003583; IPR027420; IPR011335; Crossover junction endonuclease MUS81 (EC 3.1.22.-) mus81 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31427_c0_g1_i3 Q04202 TCB2_CAEBR 4.00E-15 GO:0003677; GO:0015074; GO:0005634; GO:0004803; GO:0006313 "DNA binding; DNA integration; nucleus; transposase activity; transposition, DNA-mediated" IPR002492; Transposable element Tcb2 transposase Caenorhabditis briggsae TR31430_c0_g1_i1 Q9TU53 CUBN_CANFA 2.00E-15 GO:0005509; GO:0008203; GO:0031419; GO:0010008; GO:0005765; GO:0015031 calcium ion binding; cholesterol metabolic process; cobalamin binding; endosome membrane; lysosomal membrane; protein transport IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR009030; Cubilin CUBN Canis familiaris (Dog) (Canis lupus familiaris) TR31432_c0_g1_i1 O50655 XERD_SELRU 1.00E-06 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR31433_c6_g2_i1 Q7M3K2 PELET_DROME 1.00E-17 GO:0015074; GO:0003693; GO:0046872; GO:0016740; GO:0004803; GO:0006313 "DNA integration; P-element binding; metal ion binding; transferase activity; transposase activity; transposition, DNA-mediated" IPR022242; IPR021896; IPR006612; Transposable element P transposase (P-element transposase) (EC 2.7.7.-) (THAP domain-containing protein) (DmTHAP) T Drosophila melanogaster (Fruit fly) TR31433_c7_g2_i1 Q5VZQ5 TEX36_HUMAN 2.00E-12 Testis-expressed sequence 36 protein TEX36 C10orf122 Homo sapiens (Human) TR31436_c0_g1_i2 Q8IWR1 TRI59_HUMAN 1.00E-06 GO:0005783; GO:0016021; GO:0043124; GO:0004842; GO:0008270 endoplasmic reticulum; integral to membrane; negative regulation of I-kappaB kinase/NF-kappaB cascade; ubiquitin-protein ligase activity; zinc ion binding IPR000315; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 59 (RING finger protein 104) (Tumor suppressor TSBF-1) TRIM59 RNF104 TRIM57 TSBF1 Homo sapiens (Human) TR31437_c0_g1_i1 Q9BXJ4 C1QT3_HUMAN 3.00E-10 GO:0035356; GO:0005581; GO:0005615; GO:0045444; GO:0042593; GO:0042347; GO:0010629; GO:0045721; GO:0050728; GO:1900165; GO:0071638; GO:0070374; GO:0070165; GO:0050715; GO:0051897; GO:0070206 cellular triglyceride homeostasis; collagen; extracellular space; fat cell differentiation; glucose homeostasis; negative regulation of NF-kappaB import into nucleus; negative regulation of gene expression; negative regulation of gluconeogenesis; negative regulation of inflammatory response; negative regulation of interleukin-6 secretion; negative regulation of monocyte chemotactic protein-1 production; positive regulation of ERK1 and ERK2 cascade; positive regulation of adiponectin secretion; positive regulation of cytokine secretion; positive regulation of protein kinase B signaling cascade; protein trimerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) TR31437_c0_g2_i1 Q9BXJ4 C1QT3_HUMAN 1.00E-09 GO:0035356; GO:0005581; GO:0005615; GO:0045444; GO:0042593; GO:0042347; GO:0010629; GO:0045721; GO:0050728; GO:1900165; GO:0071638; GO:0070374; GO:0070165; GO:0050715; GO:0051897; GO:0070206 cellular triglyceride homeostasis; collagen; extracellular space; fat cell differentiation; glucose homeostasis; negative regulation of NF-kappaB import into nucleus; negative regulation of gene expression; negative regulation of gluconeogenesis; negative regulation of inflammatory response; negative regulation of interleukin-6 secretion; negative regulation of monocyte chemotactic protein-1 production; positive regulation of ERK1 and ERK2 cascade; positive regulation of adiponectin secretion; positive regulation of cytokine secretion; positive regulation of protein kinase B signaling cascade; protein trimerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) TR31438_c0_g1_i1 D4A6D7 TTC19_RAT 2.00E-17 GO:0005743; GO:0034551 mitochondrial inner membrane; mitochondrial respiratory chain complex III assembly IPR013026; IPR011990; IPR013105; "Tetratricopeptide repeat protein 19, mitochondrial (TPR repeat protein 19)" Ttc19 Rattus norvegicus (Rat) TR31440_c2_g1_i1 Q566C7 NUDT3_RAT 3.00E-45 GO:0005737; GO:0071544; GO:0008486; GO:0052840; GO:0052846; GO:0052847; GO:0052843; GO:0052848; GO:0052844; GO:0052845; GO:0000287 "cytoplasm; diphosphoinositol polyphosphate catabolic process; diphosphoinositol-polyphosphate diphosphatase activity; inositol diphosphate tetrakisphosphate diphosphatase activity; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity; inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity; inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity; magnesium ion binding" IPR020084; IPR000086; IPR015797; "Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1) (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3)" Nudt3 Dipp Dipp1 Rattus norvegicus (Rat) TR31441_c1_g2_i1 Q96GE4 CEP95_HUMAN 6.00E-50 GO:0005813; GO:0005737; GO:0000922 centrosome; cytoplasm; spindle pole IPR026619; IPR001715; Centrosomal protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45) CEP95 CCDC45 CEP45 Homo sapiens (Human) TR31441_c4_g2_i3 O94362 YHOF_SCHPO 3.00E-45 GO:0005524; GO:0016887; GO:0005525; GO:0005829; GO:0005634 ATP binding; ATPase activity; GTP binding; cytosol; nucleus IPR006073; IPR013646; IPR027417; Uncharacterized GTP-binding protein C428.15 SPBC428.15 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR31441_c7_g1_i1 Q9P2F6 RHG20_HUMAN 1.00E-15 GO:0005096; GO:0005829; GO:0005543; GO:0043547; GO:0051056; GO:0007264 GTPase activator activity; cytosol; phospholipid binding; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR011993; IPR001849; IPR000159; IPR008936; IPR000198; Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20) ARHGAP20 KIAA1391 Homo sapiens (Human) TR31443_c1_g2_i1 Q8BSY0 ASPH_MOUSE 6.00E-101 GO:0097202; GO:0032237; GO:0070588; GO:0071277; GO:0032541; GO:0005737; GO:0060325; GO:0030176; GO:0016021; GO:0035108; GO:0008285; GO:0060021; GO:0007389; GO:0004597; GO:0042264; GO:0005886; GO:0010524; GO:0090316; GO:0045862; GO:0045893; GO:0031585; GO:1901879; GO:0031647; GO:0033198 "activation of cysteine-type endopeptidase activity; activation of store-operated calcium channel activity; calcium ion transmembrane transport; cellular response to calcium ion; cortical endoplasmic reticulum; cytoplasm; face morphogenesis; integral to endoplasmic reticulum membrane; integral to membrane; limb morphogenesis; negative regulation of cell proliferation; palate development; pattern specification process; peptide-aspartate beta-dioxygenase activity; peptidyl-aspartic acid hydroxylation; plasma membrane; positive regulation of calcium ion transport into cytosol; positive regulation of intracellular protein transport; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; regulation of protein depolymerization; regulation of protein stability; response to ATP" IPR007943; IPR007803; IPR027443; IPR013026; IPR011990; IPR013105; IPR019734; Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase) Asph Mus musculus (Mouse) TR31446_c0_g1_i1 P81908 CHLE_HORSE 1.00E-99 GO:0003990; GO:0004091; GO:0005576; GO:0016020 acetylcholinesterase activity; carboxylesterase activity; extracellular region; membrane IPR014788; IPR002018; IPR019826; IPR019819; IPR000997; Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (EQ-BCHE) (Pseudocholinesterase) BCHE Equus caballus (Horse) TR31446_c0_g1_i2 Q8WMH2 NLGN3_MACMU 5.00E-09 GO:0007155; GO:0030054; GO:0009986; GO:0005887; GO:0042043; GO:0004872; GO:0045202; GO:0007416 cell adhesion; cell junction; cell surface; integral to plasma membrane; neurexin family protein binding; receptor activity; synapse; synapse assembly IPR002018; IPR000460; Neuroligin-3 (Gliotactin homolog) (Fragment) NLGN3 Macaca mulatta (Rhesus macaque) TR31447_c0_g1_i1 Q9H8H3 MET7A_HUMAN 4.00E-51 GO:0005783; GO:0005811; GO:0016020; GO:0008168 endoplasmic reticulum; lipid particle; membrane; methyltransferase activity IPR013216; Methyltransferase-like protein 7A (EC 2.1.1.-) (Protein AAM-B) METTL7A PRO0066 UNQ1902/PRO4348 Homo sapiens (Human) TR31451_c1_g1_i1 Q2IBC2 CAV2_RHIFE 8.00E-21 GO:0031748; GO:0000139; GO:0005901; GO:0070836; GO:0007029; GO:0031234; GO:0007005; GO:0001937; GO:0005634; GO:0048471; GO:0060161; GO:0048741; GO:0048278; GO:0006906 D1 dopamine receptor binding; Golgi membrane; caveola; caveola assembly; endoplasmic reticulum organization; extrinsic to internal side of plasma membrane; mitochondrion organization; negative regulation of endothelial cell proliferation; nucleus; perinuclear region of cytoplasm; positive regulation of dopamine receptor signaling pathway; skeletal muscle fiber development; vesicle docking; vesicle fusion IPR001612; IPR018361; Caveolin-2 CAV2 Rhinolophus ferrumequinum (Greater horseshoe bat) TR31451_c1_g1_i2 P33724 CAV1_CANFA 2.00E-23 GO:0000139; GO:0000165; GO:0031295; GO:0002080; GO:0001525; GO:0016324; GO:0097190; GO:0016323; GO:0006816; GO:0005901; GO:0070836; GO:0072584; GO:0005938; GO:0071455; GO:0009267; GO:0042632; GO:0005929; GO:0051480; GO:0005783; GO:0005768; GO:0000188; GO:0005887; GO:0007595; GO:0019915; GO:0060056; GO:0051899; GO:0030514; GO:0090090; GO:0001960; GO:0001937; GO:0030857; GO:0045019; GO:0051001; GO:0033137; GO:0032091; GO:0000122; GO:0042524; GO:0033484; GO:0016504; GO:0048471; GO:0010524; GO:0090263; GO:2001238; GO:2001244; GO:0048554; GO:0033138; GO:0045907; GO:0043234; GO:0051260; GO:0008104; GO:2000286; GO:0030193; GO:0019217; GO:0006940; GO:0003057; GO:0051592; GO:0043627; GO:0001666; GO:0002931; GO:0032570; GO:0007519; GO:0005198; GO:0006641; GO:0001570; GO:0042310; GO:0016050 P35222 Golgi membrane; MAPK cascade; T cell costimulation; acrosomal membrane; angiogenesis; apical plasma membrane; apoptotic signaling pathway; basolateral plasma membrane; calcium ion transport; caveola; caveola assembly; caveolin-mediated endocytosis; cell cortex; cellular response to hyperoxia; cellular response to starvation; cholesterol homeostasis; cilium; cytosolic calcium ion homeostasis; endoplasmic reticulum; endosome; inactivation of MAPK activity; integral to plasma membrane; lactation; lipid storage; mammary gland involution; membrane depolarization; negative regulation of BMP signaling pathway; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of cytokine-mediated signaling pathway; negative regulation of endothelial cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; negative regulation of peptidyl-serine phosphorylation; negative regulation of protein binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of tyrosine phosphorylation of Stat5 protein; nitric oxide homeostasis; peptidase activator activity; perinuclear region of cytoplasm; positive regulation of calcium ion transport into cytosol; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of metalloenzyme activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of vasoconstriction; protein complex; protein homooligomerization; protein localization; receptor internalization involved in canonical Wnt receptor signaling pathway; regulation of blood coagulation; regulation of fatty acid metabolic process; regulation of smooth muscle contraction; regulation of the force of heart contraction by chemical signal; response to calcium ion; response to estrogen stimulus; response to hypoxia; response to ischemia; response to progesterone stimulus; skeletal muscle tissue development; structural molecule activity; triglyceride metabolic process; vasculogenesis; vasoconstriction; vesicle organization IPR001612; IPR015504; IPR018361; Caveolin-1 (Vesicular integral-membrane protein VIP21) CAV1 CAV Canis familiaris (Dog) (Canis lupus familiaris) TR31451_c1_g1_i3 Q2QL79 CAV1_DIDVI 2.00E-24 GO:0000139; GO:0031295; GO:0005901; GO:0005768 Golgi membrane; T cell costimulation; caveola; endosome IPR001612; IPR015504; IPR018361; Caveolin-1 CAV1 Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) TR31452_c1_g1_i1 P47980 TIS1_DROME 3.00E-43 GO:0061158; GO:0003677; GO:0016246; GO:0003730; GO:0046872; GO:0005634 3'-UTR-mediated mRNA destabilization; DNA binding; RNA interference; mRNA 3'-UTR binding; metal ion binding; nucleus IPR000571; Protein TIS11 (dTIS11) Tis11 TIScc1 CG4070 Drosophila melanogaster (Fruit fly) TR31452_c1_g1_i3 P47980 TIS1_DROME 1.00E-42 GO:0061158; GO:0003677; GO:0016246; GO:0003730; GO:0046872; GO:0005634 3'-UTR-mediated mRNA destabilization; DNA binding; RNA interference; mRNA 3'-UTR binding; metal ion binding; nucleus IPR000571; Protein TIS11 (dTIS11) Tis11 TIScc1 CG4070 Drosophila melanogaster (Fruit fly) TR31455_c0_g1_i3 Q4R7V3 FR1OP_MACFA 2.00E-36 GO:0005737; GO:0034453; GO:0005815 cytoplasm; microtubule anchoring; microtubule organizing center IPR018993; IPR006594; FGFR1 oncogene partner FGFR1OP QtsA-14293 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR31455_c0_g1_i4 P0CAX8 TGAP1_MOUSE 3.00E-09 T-cell activation GTPase-activating protein 1 Tagap1 Fksg15 Mus musculus (Mouse) TR31458_c0_g1_i3 Q29290 CYTB_PIG 4.00E-21 GO:0004869; GO:0005737; GO:0010951 cysteine-type endopeptidase inhibitor activity; cytoplasm; negative regulation of endopeptidase activity IPR000010; IPR018073; IPR001713; Cystatin-B (Stefin-B) CSTB CST6 STFB Sus scrofa (Pig) TR31459_c1_g2_i1 Q93008 USP9X_HUMAN 0 GO:0030509; GO:0045177; GO:0051301; GO:0007059; GO:0004197; GO:0005829; GO:0007292; GO:0007067; GO:0000122; GO:0016579; GO:0006367; GO:0007179; GO:0004221; GO:0006511 Q13485 BMP signaling pathway; apical part of cell; cell division; chromosome segregation; cysteine-type endopeptidase activity; cytosol; female gamete generation; mitosis; negative regulation of transcription from RNA polymerase II promoter; protein deubiquitination; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR016024; IPR018200; IPR001394; "Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)" USP9X DFFRX FAM USP9 Homo sapiens (Human) TR31460_c5_g3_i1 P12276 FAS_CHICK 3.00E-22 GO:0047451; GO:0004317; GO:0004316; GO:0004315; GO:0004313; GO:0004314; GO:0047117; GO:0004319; GO:0006633; GO:0016295; GO:0004320; GO:0016296; GO:0008270 "3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; [acyl-carrier-protein] S-acetyltransferase activity; [acyl-carrier-protein] S-malonyltransferase activity; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; fatty acid biosynthetic process; myristoyl-[acyl-carrier-protein] hydrolase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; zinc ion binding" IPR001227; IPR009081; IPR014043; IPR016035; IPR013149; IPR002198; IPR023102; IPR011032; IPR018201; IPR014031; IPR014030; IPR016036; IPR016040; IPR020842; IPR020843; IPR006162; IPR001031; IPR016039; IPR016038; Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] FASN FAS Gallus gallus (Chicken) TR31462_c0_g2_i1 Q9D722 CT111_MOUSE 2.00E-06 IPR008494; Oxidative stress-responsive serine-rich protein 1 (Oxidative stress-responsive protein 1) (Peroxide-inducible transcript 1 protein) Oser1 Mus musculus (Mouse) TR31463_c0_g1_i1 B3DL65 CCD58_XENTR 3.00E-39 IPR019171; Coiled-coil domain-containing protein 58 ccdc58 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31463_c0_g1_i3 Q6PBK1 CCD58_DANRE 1.00E-12 IPR019171; Coiled-coil domain-containing protein 58 ccdc58 zgc:73369 Danio rerio (Zebrafish) (Brachydanio rerio) TR31465_c1_g2_i1 P86789 GIGA6_CRAGI 1.00E-15 GO:0016021 integral to membrane IPR001466; IPR012338; Gigasin-6 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) TR31466_c1_g2_i3 P42519 STAR_DROME 2.00E-08 GO:0005794; GO:0000139; GO:0048149; GO:0046845; GO:0046667; GO:0035225; GO:0005789; GO:0038004; GO:0007173; GO:0061331; GO:0007476; GO:0016021; GO:0007498; GO:0016318; GO:0048477; GO:0097038; GO:0007422; GO:0042461; GO:0005886; GO:0000042; GO:0048865; GO:0007421; GO:0007601 "Golgi apparatus; Golgi membrane; behavioral response to ethanol; branched duct epithelial cell fate determination, open tracheal system; compound eye retinal cell programmed cell death; determination of genital disc primordium; endoplasmic reticulum membrane; epidermal growth factor receptor ligand maturation; epidermal growth factor receptor signaling pathway; epithelial cell proliferation involved in Malpighian tubule morphogenesis; imaginal disc-derived wing morphogenesis; integral to membrane; mesoderm development; ommatidial rotation; oogenesis; perinuclear endoplasmic reticulum; peripheral nervous system development; photoreceptor cell development; plasma membrane; protein targeting to Golgi; stem cell fate commitment; stomatogastric nervous system development; visual perception" IPR006342; Protein Star S CG4385 Drosophila melanogaster (Fruit fly) TR31467_c0_g1_i1 O42412 IOD3_CHICK 5.00E-45 GO:0010008; GO:0042446; GO:0016021; GO:0005886; GO:0004800; GO:0033798 endosome membrane; hormone biosynthetic process; integral to membrane; plasma membrane; thyroxine 5'-deiodinase activity; thyroxine 5-deiodinase activity IPR000643; IPR008261; IPR027252; IPR012336; Type III iodothyronine deiodinase (EC 1.97.1.11) (5DIII) (DIOIII) (Type 3 DI) (Type-III 5'-deiodinase) (Fragment) DIO3 Gallus gallus (Chicken) TR31467_c0_g1_i2 A7YD35 IOD3_SPAAU 4.00E-43 GO:0010008; GO:0042446; GO:0016021; GO:0005886; GO:0004800; GO:0033798 endosome membrane; hormone biosynthetic process; integral to membrane; plasma membrane; thyroxine 5'-deiodinase activity; thyroxine 5-deiodinase activity IPR000643; IPR008261; IPR027252; Type III iodothyronine deiodinase (EC 1.97.1.11) (5DIII) (DIOIII) (Type 3 DI) (Type-III 5'-deiodinase) dio3 Sparus aurata (Gilthead sea bream) TR31468_c4_g1_i3 Q9Z2J0 S23A1_MOUSE 7.00E-103 GO:0008520; GO:0016324; GO:0009925; GO:0007420; GO:0005903; GO:0005737; GO:0033300; GO:0016021; GO:0043229; GO:0030324; GO:0009636; GO:0070890; GO:0070904 L-ascorbate:sodium symporter activity; apical plasma membrane; basal plasma membrane; brain development; brush border; cytoplasm; dehydroascorbic acid transporter activity; integral to membrane; intracellular organelle; lung development; response to toxic substance; sodium-dependent L-ascorbate transmembrane transporter activity; transepithelial L-ascorbic acid transport IPR006043; Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (Yolk sac permease-like molecule 3) Slc23a1 Svct1 Yspl3 Mus musculus (Mouse) TR31469_c2_g1_i1 P35992 PTP10_DROME 3.00E-43 GO:0045177; GO:0030424; GO:0007417; GO:0016021; GO:0007616; GO:0008045; GO:0007424; GO:0005886; GO:0005001 apical part of cell; axon; central nervous system development; integral to membrane; long-term memory; motor neuron axon guidance; open tracheal system development; plasma membrane; transmembrane receptor protein tyrosine phosphatase activity IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase 10D (EC 3.1.3.48) (Receptor-linked protein-tyrosine phosphatase 10D) (DPTP10D) Ptp10D CG1817 Drosophila melanogaster (Fruit fly) TR31470_c0_g2_i1 Q2LPM2 RL13_SYNAS 2.00E-18 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR005822; IPR005823; IPR023563; IPR023564; 50S ribosomal protein L13 rplM SYNAS_03350 SYN_00232 Syntrophus aciditrophicus (strain SB) TR31470_c0_g2_i2 Q9VJ38 RM13_DROME 3.00E-51 GO:0005762; GO:0003735; GO:0006412 mitochondrial large ribosomal subunit; structural constituent of ribosome; translation IPR005822; IPR023564; "39S ribosomal protein L13, mitochondrial (L13mt) (MRP-L13)" mRpL13 CG10603 Drosophila melanogaster (Fruit fly) TR31472_c0_g2_i2 Q503M4 MT12B_DANRE 1.00E-34 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12-B (MCT 12-B) (Solute carrier family 16 member 12-B) slc16a12b slc16a12 zgc:110441 Danio rerio (Zebrafish) (Brachydanio rerio) TR31473_c0_g1_i1 P36039 EMC3_YEAST 5.00E-25 GO:0072546; GO:0034975 P53045; P54837; P53337; P19145; P40540; Q06144; Q02795 ER membrane protein complex; protein folding in endoplasmic reticulum IPR002809; IPR008568; ER membrane protein complex subunit 3 (Altered inheritance rate of mitochondria protein 27) EMC3 AIM27 YKL207W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR31473_c0_g1_i2 Q7SXW4 EMC3_DANRE 4.00E-90 GO:0072546; GO:0045494; GO:0060041; GO:0030140 ER membrane protein complex; photoreceptor cell maintenance; retina development in camera-type eye; trans-Golgi network transport vesicle IPR002809; IPR008568; ER membrane protein complex subunit 3 (Protein pob) (Transmembrane protein 111) emc3 pob tmem111 zgc:63727 Danio rerio (Zebrafish) (Brachydanio rerio) TR31476_c0_g1_i3 B0K019 BAG1_RAT 1.00E-30 GO:0006915; GO:0005829; GO:0005739; GO:0043066; GO:0005634; GO:0048471; GO:0042493; GO:0010226; GO:0035094 apoptotic process; cytosol; mitochondrion; negative regulation of apoptotic process; nucleus; perinuclear region of cytoplasm; response to drug; response to lithium ion; response to nicotine IPR003103; IPR017093; IPR000626; BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1) Bag1 Rattus norvegicus (Rat) TR31478_c3_g2_i1 Q8TAD4 ZNT5_HUMAN 0 GO:0000139; GO:0016324; GO:0044267; GO:0006882; GO:0006824; GO:0005887; GO:0005730; GO:0010155; GO:0010043; GO:0030667; GO:0008270; GO:0005385 Golgi membrane; apical plasma membrane; cellular protein metabolic process; cellular zinc ion homeostasis; cobalt ion transport; integral to plasma membrane; nucleolus; regulation of proton transport; response to zinc ion; secretory granule membrane; zinc ion binding; zinc ion transmembrane transporter activity IPR002524; IPR027469; Zinc transporter 5 (ZnT-5) (Solute carrier family 30 member 5) (ZnT-like transporter 1) (hZTL1) SLC30A5 ZNT5 ZNTL1 ZTL1 UNQ863/PRO1879 Homo sapiens (Human) TR31478_c3_g2_i2 Q5ZLF4 ZNT5_CHICK 5.00E-140 GO:0005794; GO:0016324; GO:0006882; GO:0006824; GO:0016021; GO:0005730; GO:0010043; GO:0030141; GO:0005385 Golgi apparatus; apical plasma membrane; cellular zinc ion homeostasis; cobalt ion transport; integral to membrane; nucleolus; response to zinc ion; secretory granule; zinc ion transmembrane transporter activity IPR002524; IPR027469; Zinc transporter 5 (ZnT-5) (Solute carrier family 30 member 5) SLC30A5 ZNT5 RCJMB04_6h4 Gallus gallus (Chicken) TR31479_c0_g2_i1 Q32PD8 LERL1_BOVIN 1.00E-39 GO:0016021 integral to membrane IPR007262; Leptin receptor overlapping transcript-like 1 LEPROTL1 Bos taurus (Bovine) TR31482_c3_g3_i1 P25067 CO8A2_HUMAN 3.00E-08 GO:0001525; GO:0005604; GO:0048593; GO:0016337; GO:0005581; GO:0030574; GO:0005788; GO:0050673; GO:0022617; GO:0005201; GO:0030674 "angiogenesis; basement membrane; camera-type eye morphogenesis; cell-cell adhesion; collagen; collagen catabolic process; endoplasmic reticulum lumen; epithelial cell proliferation; extracellular matrix disassembly; extracellular matrix structural constituent; protein binding, bridging" IPR001073; IPR008160; IPR008983; Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) TR31482_c3_g3_i2 P08125 COAA1_CHICK 3.00E-09 GO:0005581; GO:0005576 collagen; extracellular region IPR001073; IPR008160; IPR008983; Collagen alpha-1(X) chain COL10A1 Gallus gallus (Chicken) TR31483_c0_g1_i1 Q60961 LAP4A_MOUSE 5.00E-28 GO:0012505; GO:0016021; GO:0005886; GO:0006810 endomembrane system; integral to membrane; plasma membrane; transport IPR004687; IPR018396; Lysosomal-associated transmembrane protein 4A (Golgi 4-transmembrane-spanning transporter) (Mouse transporter protein) (MTP) Laptm4a Mtrp Mus musculus (Mouse) TR31484_c0_g1_i1 Q6P635 CSN5_XENTR 0 GO:0008180; GO:0046872; GO:0008237; GO:0048471; GO:0006508 COP9 signalosome; metal ion binding; metallopeptidase activity; perinuclear region of cytoplasm; proteolysis IPR000555; COP9 signalosome complex subunit 5 (Signalosome subunit 5) (EC 3.4.-.-) cops5 csn5 TTpA010d21.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31485_c3_g1_i1 B1WB06 MET24_XENTR 5.00E-11 GO:0005576; GO:0008168 extracellular region; methyltransferase activity IPR025714; IPR026913; Methyltransferase-like protein 24 (EC 2.1.1.-) mettl24 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31486_c7_g1_i1 Q9XWB9 BAT36_CAEEL 4.00E-06 IPR000210; IPR011333; IPR013069; IPR002083; IPR008974; BTB and MATH domain-containing protein 36 bath-36 Y75B12B.4 Caenorhabditis elegans TR31487_c0_g1_i1 Q5ZJJ2 RFA1_CHICK 8.00E-24 GO:0003677; GO:0006260; GO:0016605; GO:0015629; GO:0005737; GO:0000724; GO:0046872; GO:0005654 DNA binding; DNA replication; PML body; actin cytoskeleton; cytoplasm; double-strand break repair via homologous recombination; metal ion binding; nucleoplasm IPR012340; IPR004365; IPR013955; IPR007199; IPR004591; Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) RPA1 RCJMB04_17l6 Gallus gallus (Chicken) TR31487_c0_g1_i2 Q8VEE4 RFA1_MOUSE 7.00E-27 GO:0003677; GO:0006260; GO:0003682; GO:0051276; GO:0000724; GO:0030097; GO:0048873; GO:0001701; GO:0000800; GO:0001673; GO:0007126; GO:0046872; GO:0005654; GO:0008284 DNA binding; DNA replication; chromatin binding; chromosome organization; double-strand break repair via homologous recombination; hemopoiesis; homeostasis of number of cells within a tissue; in utero embryonic development; lateral element; male germ cell nucleus; meiosis; metal ion binding; nucleoplasm; positive regulation of cell proliferation IPR012340; IPR004365; IPR013955; IPR007199; IPR004591; "Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]" Rpa1 Mus musculus (Mouse) TR31488_c0_g1_i2 Q9PTS2 DCUP_DANRE 2.00E-142 GO:0005737; GO:0006782; GO:0004853 cytoplasm; protoporphyrinogen IX biosynthetic process; uroporphyrinogen decarboxylase activity IPR006361; IPR000257; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. Uroporphyrinogen decarboxylase (UPD) (URO-D) (EC 4.1.1.37) urod Danio rerio (Zebrafish) (Brachydanio rerio) TR31492_c0_g1_i1 Q0P467 RNKA_DANRE 6.00E-26 GO:0004521; GO:0016021; GO:0009303 endoribonuclease activity; integral to membrane; rRNA transcription IPR026770; Ribonuclease kappa-A (RNase K-A) (RNase kappa-A) (EC 3.1.-.-) rnaseka zgc:153350 Danio rerio (Zebrafish) (Brachydanio rerio) TR31492_c0_g1_i4 Q0P467 RNKA_DANRE 1.00E-24 GO:0004521; GO:0016021; GO:0009303 endoribonuclease activity; integral to membrane; rRNA transcription IPR026770; Ribonuclease kappa-A (RNase K-A) (RNase kappa-A) (EC 3.1.-.-) rnaseka zgc:153350 Danio rerio (Zebrafish) (Brachydanio rerio) TR31495_c1_g1_i1 O14088 YER5_SCHPO 6.00E-46 GO:0042843; GO:0032866; GO:0032867; GO:0019568; GO:0005829; GO:0005634 D-xylose catabolic process; D-xylose:NADP reductase activity; L-arabinose:NADP reductase activity; arabinose catabolic process; cytosol; nucleus IPR001395; IPR018170; IPR020471; IPR023210; Uncharacterized oxidoreductase C2F3.05c (EC 1.-.-.-) SPAC2F3.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR31497_c0_g1_i1 Q9EPW2 KLF15_MOUSE 2.00E-46 GO:0014898; GO:0010001; GO:0072112; GO:0015758; GO:0046872; GO:2000757; GO:0005730; GO:0005634; GO:0045944; GO:0045893; GO:0003700; GO:0044212; GO:0006351 "cardiac muscle hypertrophy in response to stress; glial cell differentiation; glomerular visceral epithelial cell differentiation; glucose transport; metal ion binding; negative regulation of peptidyl-lysine acetylation; nucleolus; nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Krueppel-like factor 15 (Cardiovascular Krueppel-like factor) Klf15 Cklf Mus musculus (Mouse) TR31499_c0_g1_i1 Q09660 CC44_CAEEL 1.00E-07 GO:0020037; GO:0005506; GO:0004497; GO:0016705 "heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Probable cytochrome P450 CYP44 (EC 1.14.-.-) cyp-44A1 ccp-44 cyp44 ZK177.5 Caenorhabditis elegans TR31501_c0_g2_i1 P41233 ABCA1_MOUSE 2.00E-121 GO:0005524; GO:0006200; GO:0016887; GO:0007186; GO:0005794; GO:0008509; GO:0034188; GO:0071222; GO:0071300; GO:0033344; GO:0042632; GO:0008203; GO:0017127; GO:0016197; GO:0034380; GO:0005887; GO:0050702; GO:0032367; GO:0007040; GO:0045121; GO:0002790; GO:0045335; GO:0006911; GO:0033700; GO:0055091; GO:0045332; GO:0005548; GO:0060155; GO:0030819; GO:0010875; GO:0006497; GO:0032489; GO:0034616; GO:0055098; GO:0043691 "ATP binding; ATP catabolic process; ATPase activity; G-protein coupled receptor signaling pathway; Golgi apparatus; anion transmembrane transporter activity; apolipoprotein A-I receptor activity; cellular response to lipopolysaccharide; cellular response to retinoic acid; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transporter activity; endosomal transport; high-density lipoprotein particle assembly; integral to plasma membrane; interleukin-1 beta secretion; intracellular cholesterol transport; lysosome organization; membrane raft; peptide secretion; phagocytic vesicle; phagocytosis, engulfment; phospholipid efflux; phospholipid homeostasis; phospholipid translocation; phospholipid transporter activity; platelet dense granule organization; positive regulation of cAMP biosynthetic process; positive regulation of cholesterol efflux; protein lipidation; regulation of Cdc42 protein signal transduction; response to laminar fluid shear stress; response to low-density lipoprotein particle stimulus; reverse cholesterol transport" IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) Abca1 Abc1 Mus musculus (Mouse) TR31501_c0_g3_i2 Q8IZY2 ABCA7_HUMAN 8.00E-31 GO:0005524; GO:0006200; GO:0043190; GO:0016887; GO:0005794; GO:0000139; GO:0016324; GO:0010008; GO:0016021; GO:0006909; GO:0033700; GO:0005548; GO:0005886; GO:0055085; GO:0005215 ATP binding; ATP catabolic process; ATP-binding cassette (ABC) transporter complex; ATPase activity; Golgi apparatus; Golgi membrane; apical plasma membrane; endosome membrane; integral to membrane; phagocytosis; phospholipid efflux; phospholipid transporter activity; plasma membrane; transmembrane transport; transporter activity IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 7 (ABCA-SSN) (Autoantigen SS-N) (Macrophage ABC transporter) ABCA7 Homo sapiens (Human) TR31501_c0_g3_i3 O95477 ABCA1_HUMAN 4.00E-40 GO:0005524; GO:0006200; GO:0016887; GO:0007186; GO:0005794; GO:0008509; GO:0034188; GO:0044255; GO:0071222; GO:0071300; GO:0015485; GO:0033344; GO:0042632; GO:0008203; GO:0017127; GO:0016197; GO:0034380; GO:0005887; GO:0050702; GO:0032367; GO:0042157; GO:0007040; GO:0045121; GO:0010887; GO:0010745; GO:0002790; GO:0045335; GO:0006911; GO:0005543; GO:0033700; GO:0055091; GO:0045332; GO:0005548; GO:0060155; GO:0030819; GO:0010875; GO:0006497; GO:0032489; GO:0034616; GO:0055098; GO:0043691 Q13424; Q13884 "ATP binding; ATP catabolic process; ATPase activity; G-protein coupled receptor signaling pathway; Golgi apparatus; anion transmembrane transporter activity; apolipoprotein A-I receptor activity; cellular lipid metabolic process; cellular response to lipopolysaccharide; cellular response to retinoic acid; cholesterol binding; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transporter activity; endosomal transport; high-density lipoprotein particle assembly; integral to plasma membrane; interleukin-1 beta secretion; intracellular cholesterol transport; lipoprotein metabolic process; lysosome organization; membrane raft; negative regulation of cholesterol storage; negative regulation of macrophage derived foam cell differentiation; peptide secretion; phagocytic vesicle; phagocytosis, engulfment; phospholipid binding; phospholipid efflux; phospholipid homeostasis; phospholipid translocation; phospholipid transporter activity; platelet dense granule organization; positive regulation of cAMP biosynthetic process; positive regulation of cholesterol efflux; protein lipidation; regulation of Cdc42 protein signal transduction; response to laminar fluid shear stress; response to low-density lipoprotein particle stimulus; reverse cholesterol transport" IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein) ABCA1 ABC1 CERP Homo sapiens (Human) TR31502_c0_g1_i1 Q1ENI8 PXDN_CAEEL 1.00E-14 GO:0005576; GO:0020037; GO:0042744; GO:0046872; GO:0004601 extracellular region; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR000372; Peroxidasin homolog (EC 1.11.1.7) pxn-1 ZK994.3 Caenorhabditis elegans TR31502_c0_g1_i2 P20241 NRG_DROME 3.00E-54 GO:0008366; GO:0048675; GO:0005509; GO:0061343; GO:0048036; GO:0048813; GO:0007173; GO:0060857; GO:0008050; GO:0030175; GO:0007560; GO:0016021; GO:0016328; GO:0008049; GO:0035011; GO:0016319; GO:0021682; GO:0007158; GO:0005919; GO:0045924; GO:0035151; GO:0019991; GO:0050808; GO:0005923 "axon ensheathment; axon extension; calcium ion binding; cell adhesion involved in heart morphogenesis; central complex development; dendrite morphogenesis; epidermal growth factor receptor signaling pathway; establishment of glial blood-brain barrier; female courtship behavior; filopodium; imaginal disc morphogenesis; integral to membrane; lateral plasma membrane; male courtship behavior; melanotic encapsulation of foreign target; mushroom body development; nerve maturation; neuron cell-cell adhesion; pleated septate junction; regulation of female receptivity; regulation of tube size, open tracheal system; septate junction assembly; synapse organization; tight junction" IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013151; IPR026966; Neuroglian Nrg CG1634 Drosophila melanogaster (Fruit fly) TR31505_c0_g1_i1 Q2NLA8 ITPA_XENLA 2.00E-92 GO:0005737; GO:0009204; GO:0046872; GO:0047429; GO:0000166; GO:0009117 cytoplasm; deoxyribonucleoside triphosphate catabolic process; metal ion binding; nucleoside-triphosphate diphosphatase activity; nucleotide binding; nucleotide metabolic process IPR002637; IPR027502; Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.19) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) itpa Xenopus laevis (African clawed frog) TR31506_c2_g1_i1 Q9Z0Z3 SKP2_MOUSE 2.00E-06 GO:0000082; GO:0000086; GO:0019005; GO:0005737; GO:0005634; GO:0033148; GO:0000209; GO:0051726; GO:0006511 G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; SCF ubiquitin ligase complex; cytoplasm; nucleus; positive regulation of intracellular estrogen receptor signaling pathway; protein polyubiquitination; regulation of cell cycle; ubiquitin-dependent protein catabolic process IPR001810; Protein modification; protein ubiquitination. S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/WD-40 protein 1) (FWD1) Skp2 Mus musculus (Mouse) TR31506_c3_g2_i1 Q4KLI9 FBXW5_RAT 5.00E-22 GO:0080008; GO:0019005; GO:0031146; GO:0051298; GO:0005737; GO:0016567 Cul4-RING ubiquitin ligase complex; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; centrosome duplication; cytoplasm; protein ubiquitination IPR001810; IPR015943; IPR001680; IPR017986; Protein modification; protein ubiquitination. F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) Fbxw5 Rattus norvegicus (Rat) TR31507_c2_g1_i1 Q1LYL8 ASTE1_DANRE 5.00E-19 IPR026832; Protein asteroid homolog 1 aste1 si:dkey-11p23.5 Danio rerio (Zebrafish) (Brachydanio rerio) TR31507_c2_g1_i2 Q8BIR2 ASTE1_MOUSE 5.00E-26 IPR026832; Protein asteroid homolog 1 Aste1 Mus musculus (Mouse) TR31508_c1_g1_i2 Q5DHJ5 IFT46_SCHJA 1.00E-46 GO:0005929; GO:0005737; GO:0042073; GO:0005932 cilium; cytoplasm; intraflagellar transport; microtubule basal body IPR022088; Intraflagellar transport protein 46 homolog SJCHGC08984 Schistosoma japonicum (Blood fluke) TR31508_c1_g2_i1 Q9NQC8 IFT46_HUMAN 2.00E-53 GO:0042384; GO:0005737; GO:0042073; GO:0005932; GO:0031514; GO:0031512; GO:0005634; GO:0008022; GO:0043234; GO:0050821 cilium assembly; cytoplasm; intraflagellar transport; microtubule basal body; motile cilium; motile primary cilium; nucleus; protein C-terminus binding; protein complex; protein stabilization IPR022088; Intraflagellar transport protein 46 homolog IFT46 C11orf2 C11orf60 Homo sapiens (Human) TR31508_c1_g2_i2 A7MBP4 IFT46_DANRE 7.00E-57 GO:0005929; GO:0005737; GO:0048264; GO:0042073; GO:0005932 cilium; cytoplasm; determination of ventral identity; intraflagellar transport; microtubule basal body IPR022088; Intraflagellar transport protein 46 homolog ift46 Danio rerio (Zebrafish) (Brachydanio rerio) TR31512_c3_g1_i1 Q868T3 CCAPR_DROME 3.00E-14 GO:0018990; GO:0005887; GO:0008188; GO:0005000 "ecdysis, chitin-based cuticle; integral to plasma membrane; neuropeptide receptor activity; vasopressin receptor activity" IPR000276; IPR017452; IPR001817; Cardioacceleratory peptide receptor CcapR CG6111 Drosophila melanogaster (Fruit fly) TR31514_c1_g1_i2 P98157 LRP1_CHICK 3.00E-16 GO:0005509; GO:0005905; GO:0006897; GO:0016021 calcium ion binding; coated pit; endocytosis; integral to membrane IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) LRP1 Gallus gallus (Chicken) TR31515_c4_g2_i1 P25867 UBCD1_DROME 8.00E-73 GO:0005524; GO:0051276; GO:0001751; GO:0008054; GO:0048132; GO:0030718; GO:0007140; GO:0005875; GO:0007067; GO:0016322; GO:0045676; GO:0031647; GO:0007286; GO:0004842 ATP binding; chromosome organization; compound eye photoreceptor cell differentiation; cyclin catabolic process; female germ-line stem cell division; germ-line stem cell maintenance; male meiosis; microtubule associated complex; mitosis; neuron remodeling; regulation of R7 cell differentiation; regulation of protein stability; spermatid development; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2-17 kDa (EC 6.3.2.19) (Protein effete) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) eff UbcD1 CG7425 Drosophila melanogaster (Fruit fly) TR31515_c4_g2_i2 P62257 UBE2H_MOUSE 5.00E-22 GO:0005524; GO:0070979; GO:0070936; GO:0004842 ATP binding; protein K11-linked ubiquitination; protein K48-linked ubiquitination; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 H (EC 6.3.2.19) (UBCH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H) Ube2h Mus musculus (Mouse) TR31520_c4_g1_i1 Q6TXF1 ARRD3_RAT 1.00E-37 GO:0005737 cytoplasm IPR011021; IPR011022; IPR014756; Arrestin domain-containing protein 3 (Liver regeneration-related protein LRRG00048) Arrdc3 Rattus norvegicus (Rat) TR31520_c4_g1_i2 Q6TXF1 ARRD3_RAT 8.00E-38 GO:0005737 cytoplasm IPR011021; IPR011022; IPR014756; Arrestin domain-containing protein 3 (Liver regeneration-related protein LRRG00048) Arrdc3 Rattus norvegicus (Rat) TR31521_c0_g1_i1 Q03278 PO21_NASVI 4.00E-08 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR000477; IPR007087; IPR015880; Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 (Retrovirus-related Pol polyprotein from type I retrotransposable element R2) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] (Fragment) Nasonia vitripennis (Parasitic wasp) TR31521_c2_g1_i1 P21328 RTJK_DROME 1.00E-20 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) TR31522_c4_g1_i1 O08653 TEP1_RAT 9.00E-24 GO:0005524; GO:0003723; GO:0000781; GO:0005634; GO:0030529 "ATP binding; RNA binding; chromosome, telomeric region; nucleus; ribonucleoprotein complex" IPR025139; IPR007111; IPR027417; IPR008850; IPR008858; IPR015943; IPR001680; IPR019775; IPR017986; Telomerase protein component 1 (rTLP1) (Telomerase-associated protein 1) (Telomerase protein 1) (p230) (p240) (p80 telomerase homolog) Tep1 Tlp1 Rattus norvegicus (Rat) TR31524_c0_g1_i1 Q4R3D4 EF1D_MACFA 6.00E-60 GO:0003677; GO:0005853; GO:0005634; GO:0006355; GO:0006351; GO:0003746 "DNA binding; eukaryotic translation elongation factor 1 complex; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; translation elongation factor activity" IPR018940; IPR014717; IPR001326; IPR014038; Elongation factor 1-delta (EF-1-delta) EEF1D QthA-21064 QtsA-17735 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR31524_c0_g1_i2 P29693 EF1D_XENLA 2.00E-59 GO:0005853; GO:0003746 eukaryotic translation elongation factor 1 complex; translation elongation factor activity IPR018940; IPR014717; IPR001326; IPR014038; Elongation factor 1-delta (EF-1-delta) (P36) eef1d Xenopus laevis (African clawed frog) TR31527_c0_g1_i1 Q9QX66 DPF1_MOUSE 1.00E-89 GO:0005737; GO:0071565; GO:0007399; GO:0003676; GO:0006355; GO:0006351; GO:0008270 "cytoplasm; nBAF complex; nervous system development; nucleic acid binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR025750; IPR007087; IPR015880; IPR013087; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; "Zinc finger protein neuro-d4 (BRG1-associated factor 45B) (BAF45B) (D4, zinc and double PHD fingers family 1)" Dpf1 Baf45b Neud4 Mus musculus (Mouse) TR31527_c0_g1_i2 P58269 DPF3_MOUSE 2.00E-92 GO:0016568; GO:0071565; GO:0007399; GO:0006355; GO:0006351; GO:0008270 "chromatin modification; nBAF complex; nervous system development; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR025750; IPR007087; IPR015880; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Zinc finger protein DPF3 (BRG1-associated factor 45C) (BAF45C) (Zinc finger protein cer-d4) Dpf3 Baf45c Cerd4 Mus musculus (Mouse) TR31527_c0_g1_i3 Q9QX66 DPF1_MOUSE 1.00E-89 GO:0005737; GO:0071565; GO:0007399; GO:0003676; GO:0006355; GO:0006351; GO:0008270 "cytoplasm; nBAF complex; nervous system development; nucleic acid binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR025750; IPR007087; IPR015880; IPR013087; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; "Zinc finger protein neuro-d4 (BRG1-associated factor 45B) (BAF45B) (D4, zinc and double PHD fingers family 1)" Dpf1 Baf45b Neud4 Mus musculus (Mouse) TR31527_c0_g1_i4 P58269 DPF3_MOUSE 1.00E-92 GO:0016568; GO:0071565; GO:0007399; GO:0006355; GO:0006351; GO:0008270 "chromatin modification; nBAF complex; nervous system development; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR025750; IPR007087; IPR015880; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Zinc finger protein DPF3 (BRG1-associated factor 45C) (BAF45C) (Zinc finger protein cer-d4) Dpf3 Baf45c Cerd4 Mus musculus (Mouse) TR31530_c1_g1_i1 P08775 RPB1_MOUSE 0 GO:0003677; GO:0005665; GO:0003899; GO:0046872; GO:0006366 "DNA binding; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase activity; metal ion binding; transcription from RNA polymerase II promoter" IPR000722; IPR000684; IPR006592; IPR007080; IPR007066; IPR007083; IPR007081; IPR007075; IPR007073; DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) Polr2a Rpii215 Rpo2-1 Mus musculus (Mouse) TR31530_c1_g1_i2 P04052 RPB1_DROME 0 GO:0003677; GO:0005665; GO:0003899; GO:0046872; GO:0007095; GO:0005703; GO:0006366 "DNA binding; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase activity; metal ion binding; mitotic G2 DNA damage checkpoint; polytene chromosome puff; transcription from RNA polymerase II promoter" IPR000722; IPR000684; IPR006592; IPR007080; IPR007066; IPR007083; IPR007081; IPR007075; IPR007073; DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) RpII215 CG1554 Drosophila melanogaster (Fruit fly) TR31533_c2_g2_i2 Q9UKX7 NUP50_HUMAN 6.00E-24 GO:0005975; GO:0019221; GO:0015758; GO:0046907; GO:0051028; GO:0007077; GO:0031965; GO:0005643; GO:0005654; GO:0015031; GO:0010827; GO:0044281; GO:0055085; GO:0016032 carbohydrate metabolic process; cytokine-mediated signaling pathway; glucose transport; intracellular transport; mRNA transport; mitotic nuclear envelope disassembly; nuclear membrane; nuclear pore; nucleoplasm; protein transport; regulation of glucose transport; small molecule metabolic process; transmembrane transport; viral process IPR015007; IPR011993; IPR000156; Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) NUP50 NPAP60L PRO1146 Homo sapiens (Human) TR31534_c0_g3_i2 Q1PSW8 LIN41_MOUSE 1.00E-24 GO:0000082; GO:0000932; GO:0008543; GO:0035198; GO:0010586; GO:0035278; GO:0001843; GO:2000637; GO:0051865; GO:2000177; GO:0072089; GO:0004842; GO:0008270 G1/S transition of mitotic cell cycle; cytoplasmic mRNA processing body; fibroblast growth factor receptor signaling pathway; miRNA binding; miRNA metabolic process; negative regulation of translation involved in gene silencing by miRNA; neural tube closure; positive regulation of gene silencing by miRNA; protein autoubiquitination; regulation of neural precursor cell proliferation; stem cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (mLin41) (Tripartite motif-containing protein 71) Trim71 Gm1127 Lin41 Mus musculus (Mouse) TR31534_c0_g3_i3 Q6VVB1 NHLC1_HUMAN 7.00E-07 GO:0005783; GO:0005634; GO:0048471; GO:0031398; GO:0043161; GO:0000209; GO:0004842; GO:0008270 Q9WUA5 endoplasmic reticulum; nucleus; perinuclear region of cytoplasm; positive regulation of protein ubiquitination; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR013017; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase NHLRC1 (EC 6.3.2.-) (Malin) (NHL repeat-containing protein 1) NHLRC1 EPM2B Homo sapiens (Human) TR31534_c0_g3_i4 D2GXS7 TRIM2_AILME 3.00E-34 GO:0005737; GO:0043523; GO:0004842; GO:0008270 cytoplasm; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) TR31534_c0_g3_i6 Q80VI1 TRI56_MOUSE 2.00E-14 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) TR31536_c2_g2_i1 Q28FJ2 ANR37_XENTR 6.00E-07 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 37 ankrd37 TNeu030j10.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31536_c2_g3_i1 Q54KA7 SECG_DICDI 1.00E-09 GO:0005086; GO:0031589; GO:0006935; GO:0005829; GO:0005764; GO:0005543; GO:0032012 ARF guanyl-nucleotide exchange factor activity; cell-substrate adhesion; chemotaxis; cytosol; lysosome; phospholipid binding; regulation of ARF protein signal transduction IPR002110; IPR020683; IPR011993; IPR001849; IPR023394; IPR000904; "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) TR31536_c5_g1_i1 Q91XL9 OSBL1_MOUSE 2.00E-113 GO:0015485; GO:0005770; GO:0006869; GO:0005634; GO:0005543 cholesterol binding; late endosome; lipid transport; nucleus; phospholipid binding IPR002110; IPR020683; IPR000648; IPR018494; IPR011993; IPR001849; Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1) Osbpl1a Orp1 Orp1a Orp1l Mus musculus (Mouse) TR31536_c6_g1_i1 Q75HP9 AKT2_ORYSJ 4.00E-06 GO:0016021; GO:0005249 integral to membrane; voltage-gated potassium channel activity IPR002110; IPR020683; IPR018490; IPR000595; IPR005821; IPR021789; IPR003938; IPR014710; Potassium channel AKT2 Os05g0428700 LOC_Os05g35410 OsJ_18626 OSJNBb0048I21.3 P0636F09.19 Oryza sativa subsp. japonica (Rice) TR31536_c6_g1_i2 Q9Z2X3 PSD10_RAT 1.00E-06 GO:0006915; GO:0005737; GO:0007253; GO:0043518; GO:0043409; GO:0032088; GO:0043066; GO:0090201; GO:0000122; GO:0005634; GO:0030307; GO:0045737; GO:0032436; GO:0031398; GO:0070682 "apoptotic process; cytoplasm; cytoplasmic sequestering of NF-kappaB; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of MAPK cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of apoptotic process; negative regulation of release of cytochrome c from mitochondria; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of cell growth; positive regulation of cyclin-dependent protein kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; proteasome regulatory particle assembly" IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) Psmd10 Rattus norvegicus (Rat) TR31537_c0_g1_i1 Q13472 TOP3A_HUMAN 0 GO:0005524; GO:0003677; GO:0003917; GO:0006265; GO:0016605; GO:0005694; GO:0007126; GO:0008270 ATP binding; DNA binding; DNA topoisomerase type I activity; DNA topological change; PML body; chromosome; meiosis; zinc ion binding IPR000380; IPR003601; IPR023406; IPR013497; IPR013824; IPR013825; IPR023405; IPR003602; IPR013498; IPR006171; IPR001878; IPR010666; DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha) TOP3A TOP3 Homo sapiens (Human) TR31538_c0_g1_i1 Q56K03 RL27A_BOVIN 2.00E-59 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001196; IPR021131; 60S ribosomal protein L27a RPL27A Bos taurus (Bovine) TR31540_c4_g1_i1 Q08830 FGL1_HUMAN 2.00E-48 GO:0005577; GO:0035634 fibrinogen complex; response to stilbenoid IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein 1 (HP-041) (Hepassocin) (Hepatocyte-derived fibrinogen-related protein 1) (HFREP-1) (Liver fibrinogen-related protein 1) (LFIRE-1) FGL1 HFREP1 Homo sapiens (Human) TR31540_c4_g1_i2 P19477 FIBA_PARPA 8.00E-51 IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein A (FREP-A) Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) TR31540_c4_g1_i3 E2IYB3 FCNV1_VARKO 2.00E-28 GO:0005576 extracellular region IPR008160; IPR014716; IPR002181; Veficolin-1 (Fragment) Varanus komodoensis (Komodo dragon) TR31540_c4_g1_i6 P19477 FIBA_PARPA 9.00E-51 IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein A (FREP-A) Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) TR31540_c4_g1_i8 E2IYB3 FCNV1_VARKO 3.00E-28 GO:0005576 extracellular region IPR008160; IPR014716; IPR002181; Veficolin-1 (Fragment) Varanus komodoensis (Komodo dragon) TR31540_c4_g1_i9 Q3SZZ7 FGL1_BOVIN 2.00E-48 GO:0005576 extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein 1 FGL1 Bos taurus (Bovine) TR31540_c4_g4_i3 P10039 TENA_CHICK 7.00E-41 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) TNC Gallus gallus (Chicken) TR31543_c0_g1_i1 P12689 REV1_YEAST 7.00E-18 GO:0006260; GO:0003887; GO:0003684; GO:0017125; GO:0070987; GO:0042276; GO:0000287; GO:0005739; GO:0005634; GO:0005657 P38927 DNA replication; DNA-directed DNA polymerase activity; damaged DNA binding; deoxycytidyl transferase activity; error-free translesion synthesis; error-prone translesion synthesis; magnesium ion binding; mitochondrion; nucleus; replication fork IPR001357; IPR017961; IPR001126; IPR017963; IPR012112; DNA repair protein REV1 (EC 2.7.7.-) (Reversionless protein 1) REV1 YOR346W O6339 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR31543_c1_g2_i1 Q5R4N7 REV1_PONAB 1.00E-101 GO:0006281; GO:0006260; GO:0003887; GO:0003684; GO:0000287; GO:0005634 DNA repair; DNA replication; DNA-directed DNA polymerase activity; damaged DNA binding; magnesium ion binding; nucleus IPR001357; IPR017961; IPR001126; IPR017963; IPR012112; DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase) REV1 REV1L Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR31543_c1_g2_i2 O94623 REV1_SCHPO 2.00E-41 GO:0006260; GO:0003887; GO:0003684; GO:0017125; GO:0000287; GO:0043504; GO:0005739; GO:0005730; GO:0035861; GO:0005819 DNA replication; DNA-directed DNA polymerase activity; damaged DNA binding; deoxycytidyl transferase activity; magnesium ion binding; mitochondrial DNA repair; mitochondrion; nucleolus; site of double-strand break; spindle IPR001357; IPR017961; IPR001126; IPR017963; IPR012112; DNA repair protein rev1 (EC 2.7.7.-) (Reversionless protein 1) rev1 SPBC1347.01c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR31544_c0_g1_i3 D4GYG7 AGLE_HALVD 1.00E-10 GO:0045232; GO:0005886; GO:0016757 "S-layer organization; plasma membrane; transferase activity, transferring glycosyl groups" IPR001173; Cell surface structure biogenesis; S-layer biogenesis. Glycosyltransferase AglE (EC 2.4.1.-) (Archaeal glycosylation protein E) aglE HVO_1523.1 HVO_1523A Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) TR31544_c0_g1_i4 Q1RIM7 Y706_RICBR 2.00E-08 GO:0016757 "transferase activity, transferring glycosyl groups" IPR001173; Uncharacterized glycosyltransferase RBE_0706 (EC 2.4.-.-) RBE_0706 Rickettsia bellii (strain RML369-C) TR31544_c0_g2_i1 Q6GV29 B3GNL_RAT 5.00E-105 GO:0016757 "transferase activity, transferring glycosyl groups" IPR001173; "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 (BGnT-like protein 1) (Beta1,3-N-acetylglucosaminyltransferase-like protein 1) (Beta3Gn-T-like protein 1) (Beta3GnTL1) (EC 2.4.1.-)" B3gntl1 Rattus norvegicus (Rat) TR31544_c0_g2_i2 Q6GV29 B3GNL_RAT 4.00E-104 GO:0016757 "transferase activity, transferring glycosyl groups" IPR001173; "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 (BGnT-like protein 1) (Beta1,3-N-acetylglucosaminyltransferase-like protein 1) (Beta3Gn-T-like protein 1) (Beta3GnTL1) (EC 2.4.1.-)" B3gntl1 Rattus norvegicus (Rat) TR31545_c0_g2_i1 Q9R0Q9 MPU1_MOUSE 2.00E-74 GO:0016021; GO:0006810 integral to membrane; transport IPR006603; IPR016817; Mannose-P-dolichol utilization defect 1 protein (Suppressor of Lec15 and Lec35 glycosylation mutation homolog) (SL15) Mpdu1 Supl15h Mus musculus (Mouse) TR31546_c1_g1_i1 Q62255 SALL3_MOUSE 6.00E-13 GO:0003677; GO:0035136; GO:0035137; GO:0046872; GO:0045879; GO:0005634; GO:0021891; GO:0006355; GO:0006351 "DNA binding; forelimb morphogenesis; hindlimb morphogenesis; metal ion binding; negative regulation of smoothened signaling pathway; nucleus; olfactory bulb interneuron development; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Sal-like protein 3 (MSal) (Spalt-like protein 3) Sall3 Sal Mus musculus (Mouse) TR31546_c5_g1_i1 Q8TB69 ZN519_HUMAN 6.00E-28 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 519 ZNF519 Homo sapiens (Human) TR31546_c5_g2_i1 Q9BYN7 ZN341_HUMAN 6.00E-55 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; IPR013083; Zinc finger protein 341 ZNF341 Homo sapiens (Human) TR31550_c4_g1_i1 Q9WTS5 TEN2_MOUSE 6.00E-113 GO:0005794; GO:0016605; GO:0007411; GO:0035584; GO:0050839; GO:0005911; GO:0043197; GO:0005783; GO:0030175; GO:0030426; GO:0007157; GO:0005887; GO:0000122; GO:0051491; GO:0045211; GO:0046982; GO:0042803; GO:0005102; GO:0006351 "Golgi apparatus; PML body; axon guidance; calcium-mediated signaling using intracellular calcium source; cell adhesion molecule binding; cell-cell junction; dendritic spine; endoplasmic reticulum; filopodium; growth cone; heterophilic cell-cell adhesion; integral to plasma membrane; negative regulation of transcription from RNA polymerase II promoter; positive regulation of filopodium assembly; postsynaptic membrane; protein heterodimerization activity; protein homodimerization activity; receptor binding; transcription, DNA-dependent" IPR011042; IPR008969; IPR000742; IPR013032; IPR022385; IPR027690; IPR009471; IPR006530; "Teneurin-2 (Ten-2) (Protein Odd Oz/ten-m homolog 2) (Tenascin-M2) (Ten-m2) (Teneurin transmembrane protein 2) [Cleaved into: Ten-2, soluble form; Ten-2 intracellular domain (Ten-2 ICD)]" Tenm2 Kiaa1127 Odz2 Tnm2 Mus musculus (Mouse) TR31550_c4_g2_i1 Q9P273 TEN3_HUMAN 2.00E-106 GO:0030424; GO:0007156; GO:0016021; GO:0016020; GO:0010976; GO:0046982; GO:0042803; GO:0007165 axon; homophilic cell adhesion; integral to membrane; membrane; positive regulation of neuron projection development; protein heterodimerization activity; protein homodimerization activity; signal transduction IPR011042; IPR008969; IPR000742; IPR013032; IPR022385; IPR027689; IPR009471; IPR017986; IPR006530; Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) TENM3 KIAA1455 ODZ3 TNM3 Homo sapiens (Human) TR31554_c0_g1_i2 P42519 STAR_DROME 4.00E-16 GO:0005794; GO:0000139; GO:0048149; GO:0046845; GO:0046667; GO:0035225; GO:0005789; GO:0038004; GO:0007173; GO:0061331; GO:0007476; GO:0016021; GO:0007498; GO:0016318; GO:0048477; GO:0097038; GO:0007422; GO:0042461; GO:0005886; GO:0000042; GO:0048865; GO:0007421; GO:0007601 "Golgi apparatus; Golgi membrane; behavioral response to ethanol; branched duct epithelial cell fate determination, open tracheal system; compound eye retinal cell programmed cell death; determination of genital disc primordium; endoplasmic reticulum membrane; epidermal growth factor receptor ligand maturation; epidermal growth factor receptor signaling pathway; epithelial cell proliferation involved in Malpighian tubule morphogenesis; imaginal disc-derived wing morphogenesis; integral to membrane; mesoderm development; ommatidial rotation; oogenesis; perinuclear endoplasmic reticulum; peripheral nervous system development; photoreceptor cell development; plasma membrane; protein targeting to Golgi; stem cell fate commitment; stomatogastric nervous system development; visual perception" IPR006342; Protein Star S CG4385 Drosophila melanogaster (Fruit fly) TR31555_c0_g1_i1 Q8IVB5 LIX1L_HUMAN 4.00E-136 LIX1-like protein LIX1L Homo sapiens (Human) TR31560_c0_g1_i1 Q9H1X1 RSPH9_HUMAN 7.00E-100 GO:0035085; GO:0035083; GO:0003341; GO:0005856 cilium axoneme; cilium axoneme assembly; cilium movement; cytoskeleton IPR006802; Radial spoke head protein 9 homolog RSPH9 C6orf206 MRPS18AL1 Homo sapiens (Human) TR31561_c0_g1_i1 A8MXY4 ZNF99_HUMAN 5.00E-19 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 99 ZNF99 C19orf9 Homo sapiens (Human) TR31561_c1_g1_i1 Q8NDX6 ZN740_HUMAN 1.00E-12 GO:0046872; GO:0003676; GO:0005634; GO:0006355; GO:0006351 "metal ion binding; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 740 (OriLyt TD-element-binding protein 7) ZNF740 TB7 Homo sapiens (Human) TR31564_c0_g2_i2 Q9NVH0 EXD2_HUMAN 7.00E-134 GO:0008408; GO:0003676; GO:0090305 3'-5' exonuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis IPR002562; IPR012337; Exonuclease 3'-5' domain-containing protein 2 (Exonuclease 3'-5' domain-like-containing protein 2) EXD2 C14orf114 EXDL2 Homo sapiens (Human) TR31565_c1_g2_i1 A4IFD0 KAD5_BOVIN 5.00E-16 GO:0005524; GO:0046034; GO:0004017; GO:0005813; GO:0005737; GO:0004550; GO:0019206; GO:0009142 ATP binding; ATP metabolic process; adenylate kinase activity; centrosome; cytoplasm; nucleoside diphosphate kinase activity; nucleoside kinase activity; nucleoside triphosphate biosynthetic process IPR000850; IPR006267; IPR003117; IPR027417; Adenylate kinase isoenzyme 5 (AK 5) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 5) Ak5 Bos taurus (Bovine) TR31565_c4_g1_i1 P00568 KAD1_HUMAN 2.00E-11 GO:0005524; GO:0046034; GO:0004017; GO:0007050; GO:0005829; GO:0015949; GO:0004550; GO:0009142; GO:0001520; GO:0005886; GO:0036126 ATP binding; ATP metabolic process; adenylate kinase activity; cell cycle arrest; cytosol; nucleobase-containing small molecule interconversion; nucleoside diphosphate kinase activity; nucleoside triphosphate biosynthetic process; outer dense fiber; plasma membrane; sperm flagellum IPR000850; IPR006267; IPR027417; Adenylate kinase isoenzyme 1 (AK 1) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (Myokinase) AK1 Homo sapiens (Human) TR31568_c0_g1_i1 Q5BLE8 RETST_DANRE 2.00E-87 GO:0051786; GO:0005789 "all-trans-retinol 13,14-reductase activity; endoplasmic reticulum membrane" "Putative all-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat)" retsat zgc:113107 Danio rerio (Zebrafish) (Brachydanio rerio) TR31570_c1_g1_i1 Q8SR86 CDK1_ENCCU 7.00E-12 GO:0005524; GO:0051301; GO:0004693; GO:0007067; GO:0005634 ATP binding; cell division; cyclin-dependent protein serine/threonine kinase activity; mitosis; nucleus IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 1 (CDK1) (Cell division control protein 28 homolog) (EC 2.7.11.22) (Cell division protein kinase 1) CDC28 CDK1 ECU08_1920 Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) TR31570_c1_g3_i1 Q9Y6R4 M3K4_HUMAN 1.00E-12 GO:0005524; GO:0007254; GO:0004709; GO:0060718; GO:0005737; GO:0019100; GO:0046872; GO:0048471; GO:0001890; GO:0043507; GO:0010468 O75369; O75293; Q96B97; P0CG48 ATP binding; JNK cascade; MAP kinase kinase kinase activity; chorionic trophoblast cell differentiation; cytoplasm; male germ-line sex determination; metal ion binding; perinuclear region of cytoplasm; placenta development; positive regulation of JUN kinase activity; regulation of gene expression IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) MAP3K4 KIAA0213 MAPKKK4 MEKK4 MTK1 Homo sapiens (Human) TR31570_c1_g3_i2 Q8XJL8 PKN2_CLOPE 1.00E-13 GO:0005524; GO:0008658; GO:0004674 ATP binding; penicillin binding; protein serine/threonine kinase activity IPR011009; IPR005543; IPR000719; IPR017441; IPR008271; Probable serine/threonine-protein kinase CPE1738 (EC 2.7.11.1) CPE1738 Clostridium perfringens (strain 13 / Type A) TR31570_c1_g3_i3 Q9QYZ3 SMK2B_MOUSE 9.00E-14 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR002290; IPR008271; Sperm motility kinase 2B (EC 2.7.11.1) Smok2b Gm1847 Mus musculus (Mouse) TR31570_c1_g3_i4 Q54XQ2 RCKA_DICDI 9.00E-11 GO:0005524; GO:0007189; GO:0005737; GO:0007275; GO:0005886; GO:0050921; GO:0004672; GO:0004674; GO:0038032 ATP binding; adenylate cyclase-activating G-protein coupled receptor signaling pathway; cytoplasm; multicellular organismal development; plasma membrane; positive regulation of chemotaxis; protein kinase activity; protein serine/threonine kinase activity; termination of G-protein coupled receptor signaling pathway IPR011009; IPR000719; IPR016137; IPR000342; IPR001245; IPR008271; RGS domain-containing serine/threonine-protein kinase A (EC 2.7.11.1) (RGS domain-containing serine/threonine-protein kinase 1) rckA rck1 DDB_G0278737 Dictyostelium discoideum (Slime mold) TR31574_c2_g1_i1 Q8N2E2 VWDE_HUMAN 3.00E-37 GO:0005576 extracellular region IPR000742; IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) TR31574_c3_g2_i1 O88278 CELR3_RAT 1.00E-11 GO:0004930; GO:0007413; GO:0005509; GO:0042384; GO:0007156; GO:0016021; GO:0001764; GO:0007218; GO:0005886; GO:0032880 G-protein coupled receptor activity; axonal fasciculation; calcium ion binding; cilium assembly; homophilic cell adhesion; integral to membrane; neuron migration; neuropeptide signaling pathway; plasma membrane; regulation of protein localization IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR013032; IPR002049; IPR017981; IPR001879; IPR000832; IPR017983; IPR000203; IPR001791; Cadherin EGF LAG seven-pass G-type receptor 3 (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) Celsr3 Megf2 Rattus norvegicus (Rat) TR31574_c3_g2_i2 Q96QV1 HHIP_HUMAN 3.00E-06 GO:0005975; GO:0009986; GO:0005737; GO:0009953; GO:0060441; GO:0005576; GO:0005887; GO:0045879; GO:0007405; GO:0016901; GO:0048038; GO:0040036; GO:0048705; GO:0007224; GO:0008270 "carbohydrate metabolic process; cell surface; cytoplasm; dorsal/ventral pattern formation; epithelial tube branching involved in lung morphogenesis; extracellular region; integral to plasma membrane; negative regulation of smoothened signaling pathway; neuroblast proliferation; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor; quinone binding; regulation of fibroblast growth factor receptor signaling pathway; skeletal system morphogenesis; smoothened signaling pathway; zinc ion binding" IPR011042; IPR000742; IPR013032; IPR018143; IPR012938; IPR011041; Hedgehog-interacting protein (HHIP) (HIP) HHIP HIP UNQ5825/PRO19644 Homo sapiens (Human) TR31575_c0_g1_i1 Q8D342 ARNC_WIGBR 4.00E-07 GO:0036108; GO:0016021; GO:0009245; GO:0009103; GO:0016780; GO:0005886; GO:0046677; GO:0016757 "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process; integral to membrane; lipid A biosynthetic process; lipopolysaccharide biosynthetic process; phosphotransferase activity, for other substituted phosphate groups; plasma membrane; response to antibiotic; transferase activity, transferring glycosyl groups" IPR022857; IPR001173; Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 1/2. Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase (EC 2.4.2.53) (Undecaprenyl-phosphate Ara4FN transferase) (Ara4FN transferase) arnC WIGBR1590 Wigglesworthia glossinidia brevipalpis TR31576_c2_g1_i1 Q0P4W3 RMD2_XENTR 2.00E-55 GO:0016021 integral to membrane IPR011990 Regulator of microtubule dynamics protein 2 (RMD-2) (Protein FAM82A1) rmdn2 fam82a fam82a1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31577_c0_g1_i1 Q9WYG0 Y325_THEMA 2.00E-26 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Uncharacterized oxidoreductase TM_0325 (EC 1.-.-.-) TM_0325 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR31577_c0_g1_i2 Q2FVD5 Y2778_STAA8 3.00E-23 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; Uncharacterized oxidoreductase SAOUHSC_02778 (EC 1.-.-.-) SAOUHSC_02778 Staphylococcus aureus (strain NCTC 8325) TR31577_c0_g1_i3 Q8MJY8 PGDH_MACFA 1.00E-60 GO:0016404; GO:0070403; GO:0005737; GO:0097070; GO:0007565; GO:0045786; GO:0030728; GO:0007567; GO:0004957; GO:0006693; GO:0070493; GO:0007179 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; NAD+ binding; cytoplasm; ductus arteriosus closure; female pregnancy; negative regulation of cell cycle; ovulation; parturition; prostaglandin E receptor activity; prostaglandin metabolic process; thrombin receptor signaling pathway; transforming growth factor beta receptor signaling pathway IPR002198; IPR002347; IPR016040; IPR020904; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) HPGD PGDH1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR31580_c0_g1_i1 P0C6B8 SVEP1_RAT 2.00E-16 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) TR31580_c0_g1_i2 Q2PZL6 FAT4_MOUSE 5.00E-19 GO:0045177; GO:0001658; GO:0005509; GO:0048565; GO:0001736; GO:0003007; GO:0007156; GO:0060122; GO:0016021; GO:0001822; GO:0043931; GO:0005886; GO:0007009 apical part of cell; branching involved in ureteric bud morphogenesis; calcium ion binding; digestive tract development; establishment of planar polarity; heart morphogenesis; homophilic cell adhesion; inner ear receptor stereocilium organization; integral to membrane; kidney development; ossification involved in bone maturation; plasma membrane; plasma membrane organization IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) Fat4 Fatj Mus musculus (Mouse) TR31580_c0_g1_i3 Q9NYQ8 FAT2_HUMAN 3.00E-12 GO:0005509; GO:0005913; GO:0010631; GO:0007156; GO:0016021; GO:0005634; GO:0005886 calcium ion binding; cell-cell adherens junction; epithelial cell migration; homophilic cell adhesion; integral to membrane; nucleus; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR013032; IPR001791; Protocadherin Fat 2 (hFat2) (Cadherin family member 8) (Multiple epidermal growth factor-like domains protein 1) (Multiple EGF-like domains protein 1) FAT2 CDHF8 KIAA0811 MEGF1 Homo sapiens (Human) TR31582_c1_g1_i1 Q7TNL4 STK40_RAT 4.00E-129 GO:0005524; GO:0005737; GO:0005634; GO:0004674 ATP binding; cytoplasm; nucleus; protein serine/threonine kinase activity IPR011009; IPR000719; IPR024236; IPR008271; IPR024104; Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine-protein kinase lyk4) Stk40 Lyk4 Rattus norvegicus (Rat) TR31582_c1_g1_i2 Q5GLH2 TRIB2_BOVIN 3.00E-27 GO:0005737; GO:0005856; GO:0045599; GO:0045081; GO:0006469; GO:0005634; GO:0032436; GO:0004860; GO:0043405; GO:0016772; GO:0055106 "cytoplasm; cytoskeleton; negative regulation of fat cell differentiation; negative regulation of interleukin-10 biosynthetic process; negative regulation of protein kinase activity; nucleus; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein kinase inhibitor activity; regulation of MAP kinase activity; transferase activity, transferring phosphorus-containing groups; ubiquitin-protein ligase regulator activity" IPR011009; IPR000719; IPR024104; Tribbles homolog 2 (TRB-2) TRIB2 Bos taurus (Bovine) TR31582_c1_g1_i3 Q8N2I9 STK40_HUMAN 5.00E-151 GO:0005524; GO:0005737; GO:0005634; GO:0004674 ATP binding; cytoplasm; nucleus; protein serine/threonine kinase activity IPR011009; IPR000719; IPR024236; IPR008271; IPR024104; Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase) (Sugen kinase 495) (SgK495) STK40 SGK495 SHIK Homo sapiens (Human) TR31583_c0_g1_i1 Q9DA37 SAMD8_MOUSE 1.00E-77 GO:0046513; GO:0030176; GO:2000303; GO:0006686; GO:0016740 ceramide biosynthetic process; integral to endoplasmic reticulum membrane; regulation of ceramide biosynthetic process; sphingomyelin biosynthetic process; transferase activity IPR001660; IPR013761; IPR021129; IPR025749; Sphingomyelin synthase-related protein 1 (SMSr) (EC 2.7.8.-) (Ceramide phosphoethanolamine synthase) (CPE synthase) (Sterile alpha motif domain-containing protein 8) (SAM domain-containing protein 8) Samd8 Mus musculus (Mouse) TR31585_c0_g1_i1 Q6GLJ1 BTBDH_XENLA 3.00E-08 GO:0005576 extracellular region IPR011705; IPR000210; IPR011333; IPR013069; BTB/POZ domain-containing protein 17 btbd17 Xenopus laevis (African clawed frog) TR31587_c1_g1_i1 O13770 YE98_SCHPO 2.00E-24 GO:0030134; GO:0006888; GO:0005794; GO:0005783; GO:0005789; GO:0016021; GO:0006886 ER to Golgi transport vesicle; ER to Golgi vesicle-mediated transport; Golgi apparatus; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; intracellular protein transport IPR009038; Uncharacterized membrane protein C17A5.08 SPAC17A5.08 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR31587_c1_g1_i2 D3ZTX0 TMED7_RAT 8.00E-52 GO:0030663; GO:0012507; GO:0005794; GO:0005783; GO:0005789; GO:0005793; GO:0033116; GO:0016021; GO:0015031 COPI-coated vesicle membrane; ER to Golgi transport vesicle membrane; Golgi apparatus; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; protein transport IPR009038; IPR015718; Transmembrane emp24 domain-containing protein 7 (p24 family protein gamma-3) (p24gamma3) (p27) Tmed7 Rattus norvegicus (Rat) TR31589_c1_g3_i1 Q9Y6F7 CDY2_HUMAN 2.00E-44 GO:0016573; GO:0004402; GO:0005634; GO:0007283 histone acetylation; histone acetyltransferase activity; nucleus; spermatogenesis IPR017984; IPR023780; IPR000953; IPR016197; IPR023779; IPR001753; Testis-specific chromodomain protein Y 2 (EC 2.3.1.48) CDY2A CDY2; CDY2B Homo sapiens (Human) TR31589_c7_g1_i1 Q9WTK2 CDYL_MOUSE 8.00E-08 GO:0016573; GO:0004402; GO:0035064; GO:0005634; GO:0006355; GO:0003714; GO:0006351 "histone acetylation; histone acetyltransferase activity; methylated histone residue binding; nucleus; regulation of transcription, DNA-dependent; transcription corepressor activity; transcription, DNA-dependent" IPR023780; IPR000953; IPR016197; IPR023779; IPR001753; Chromodomain Y-like protein (CDY-like) (EC 2.3.1.48) Cdyl Mus musculus (Mouse) TR31591_c0_g1_i1 Q9R1N3 S4A7_RAT 2.00E-09 GO:0016324; GO:0016323; GO:0031410; GO:0005452; GO:0016021; GO:0006814; GO:0032420; GO:0015293 apical plasma membrane; basolateral plasma membrane; cytoplasmic vesicle; inorganic anion exchanger activity; integral to membrane; sodium ion transport; stereocilium; symporter activity IPR013769; IPR011531; IPR003020; IPR016152; Sodium bicarbonate cotransporter 3 (Electroneutral sodium bicarbonate cotransporter 1) (NBC-like protein) (Solute carrier family 4 member 7) Slc4a7 Nbc Nbc2 Nbc3 Nbcn1 Rattus norvegicus (Rat) TR31591_c0_g2_i2 Q60648 SAP3_MOUSE 7.00E-11 GO:0004563; GO:0008047; GO:0006689; GO:0007611; GO:0019915; GO:0005764; GO:0005739; GO:0050885; GO:0005730; GO:0009313 beta-N-acetylhexosaminidase activity; enzyme activator activity; ganglioside catabolic process; learning or memory; lipid storage; lysosome; mitochondrion; neuromuscular process controlling balance; nucleolus; oligosaccharide catabolic process IPR003172; Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) Gm2a Mus musculus (Mouse) TR31591_c0_g2_i5 Q60648 SAP3_MOUSE 1.00E-11 GO:0004563; GO:0008047; GO:0006689; GO:0007611; GO:0019915; GO:0005764; GO:0005739; GO:0050885; GO:0005730; GO:0009313 beta-N-acetylhexosaminidase activity; enzyme activator activity; ganglioside catabolic process; learning or memory; lipid storage; lysosome; mitochondrion; neuromuscular process controlling balance; nucleolus; oligosaccharide catabolic process IPR003172; Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) Gm2a Mus musculus (Mouse) TR31591_c0_g3_i1 Q9R1N3 S4A7_RAT 6.00E-13 GO:0016324; GO:0016323; GO:0031410; GO:0005452; GO:0016021; GO:0006814; GO:0032420; GO:0015293 apical plasma membrane; basolateral plasma membrane; cytoplasmic vesicle; inorganic anion exchanger activity; integral to membrane; sodium ion transport; stereocilium; symporter activity IPR013769; IPR011531; IPR003020; IPR016152; Sodium bicarbonate cotransporter 3 (Electroneutral sodium bicarbonate cotransporter 1) (NBC-like protein) (Solute carrier family 4 member 7) Slc4a7 Nbc Nbc2 Nbc3 Nbcn1 Rattus norvegicus (Rat) TR31592_c1_g2_i1 P15626 GSTM2_MOUSE 1.00E-54 GO:0005737; GO:0004364; GO:0046982; GO:0042803 cytoplasm; glutathione transferase activity; protein heterodimerization activity; protein homodimerization activity IPR010987; IPR004045; IPR004046; IPR003081; IPR012336; Glutathione S-transferase Mu 2 (EC 2.5.1.18) (GST 5-5) (GST class-mu 2) (Glutathione S-transferase pmGT2) Gstm2 Mus musculus (Mouse) TR31596_c0_g1_i1 Q8VC34 RPAP2_MOUSE 3.00E-42 GO:0008420; GO:0016591; GO:0005737; GO:0070940; GO:0046872; GO:0009301 "CTD phosphatase activity; DNA-directed RNA polymerase II, holoenzyme; cytoplasm; dephosphorylation of RNA polymerase II C-terminal domain; metal ion binding; snRNA transcription" IPR007308; Putative RNA polymerase II subunit B1 CTD phosphatase Rpap2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2) Rpap2 Mus musculus (Mouse) TR316_c1_g1_i1 Q61398 PCOC1_MOUSE 2.00E-13 GO:0005518; GO:0031012; GO:0005615; GO:0070062; GO:0008201; GO:0016504; GO:0006508 collagen binding; extracellular matrix; extracellular space; extracellular vesicular exosome; heparin binding; peptidase activator activity; proteolysis IPR000859; IPR001134; IPR018933; IPR008993; Procollagen C-endopeptidase enhancer 1 (P14) (Procollagen COOH-terminal proteinase enhancer 1) (PCPE-1) (Procollagen C-proteinase enhancer 1) (Type 1 procollagen C-proteinase enhancer protein) (Type I procollagen COOH-terminal proteinase enhancer) Pcolce Pcpe1 Mus musculus (Mouse) TR3160_c0_g1_i1 Q5SZI1 LRAD2_HUMAN 2.00E-07 GO:0016021 integral to membrane IPR000859; IPR002172; Low-density lipoprotein receptor class A domain-containing protein 2 LDLRAD2 Homo sapiens (Human) TR31600_c2_g1_i1 Q5SUR0 PUR4_MOUSE 2.00E-105 GO:0006189; GO:0005524; GO:0005737; GO:0006541; GO:0004642 'de novo' IMP biosynthetic process; ATP binding; cytoplasm; glutamine metabolic process; phosphoribosylformylglycinamidine synthase activity IPR010918; IPR000728; IPR017926; IPR010073; IPR016188; Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribotide amidotransferase) (FGARAT) (Formylglycinamide ribotide synthetase) Pfas Kiaa0361 Mus musculus (Mouse) TR31601_c0_g1_i1 Q32PY2 LIPH_RAT 6.00E-57 GO:0005576; GO:0016787; GO:0016042; GO:0016020 extracellular region; hydrolase activity; lipid catabolic process; membrane IPR000734; IPR013818; IPR016272; Lipase member H (EC 3.1.1.-) Liph Rattus norvegicus (Rat) TR31601_c0_g1_i3 Q64424 LIPR2_MYOCO 1.00E-77 GO:0047372; GO:0005509; GO:0005615; GO:0047714; GO:0019376; GO:0004620; GO:0009395; GO:0004806 acylglycerol lipase activity; calcium ion binding; extracellular space; galactolipase activity; galactolipid catabolic process; phospholipase activity; phospholipid catabolic process; triglyceride lipase activity IPR000734; IPR008976; IPR013818; IPR002331; IPR016272; IPR001024; Pancreatic lipase-related protein 2 (PL-RP2) (EC 3.1.1.26) (EC 3.1.1.3) (Galactolipase) PNLIPRP2 Myocastor coypus (Coypu) (Nutria) TR31609_c1_g1_i1 Q9MYW9 OPRM_MACMU 1.00E-07 GO:0001965; GO:0004979; GO:0016021; GO:0038047; GO:0061358; GO:0007194; GO:0043951; GO:0045019; GO:0007200; GO:0005886; GO:0070374; GO:0050769; GO:0051481; GO:2000310; GO:0019233; GO:0005245 G-protein alpha-subunit binding; beta-endorphin receptor activity; integral to membrane; morphine receptor activity; negative regulation of Wnt protein secretion; negative regulation of adenylate cyclase activity; negative regulation of cAMP-mediated signaling; negative regulation of nitric oxide biosynthetic process; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; positive regulation of ERK1 and ERK2 cascade; positive regulation of neurogenesis; reduction of cytosolic calcium ion concentration; regulation of N-methyl-D-aspartate selective glutamate receptor activity; sensory perception of pain; voltage-gated calcium channel activity IPR000276; IPR017452; IPR000105; IPR001418; Mu-type opioid receptor (M-OR-1) (MOR-1) OPRM1 MOR1 Macaca mulatta (Rhesus macaque) TR31610_c1_g2_i1 O08715 AKAP1_MOUSE 1.00E-75 GO:0003723; GO:0005783; GO:0016021; GO:0005741; GO:0005739 Q16825; Q06986 RNA binding; endoplasmic reticulum; integral to membrane; mitochondrial outer membrane; mitochondrion IPR004087; IPR004088; IPR002999; "A-kinase anchor protein 1, mitochondrial (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein) (S-AKAP)" Akap1 Akap Mus musculus (Mouse) TR31610_c1_g2_i2 Q09285 YQK1_CAEEL 6.00E-48 GO:0003723 RNA binding IPR004087; IPR004088; IPR002999; KH domain-containing protein C56G2.1 C56G2.1/C56G2.2 Caenorhabditis elegans TR31613_c1_g1_i1 Q80YV3 TRRAP_MOUSE 0 GO:0035267; GO:0043968; GO:0043967; GO:0007093; GO:0016773; GO:0006355; GO:0003713; GO:0005667; GO:0006351 Q9JHD2 "NuA4 histone acetyltransferase complex; histone H2A acetylation; histone H4 acetylation; mitotic cell cycle checkpoint; phosphotransferase activity, alcohol group as acceptor; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription factor complex; transcription, DNA-dependent" IPR016024; IPR003152; IPR011009; IPR000403; IPR003151; IPR014009; IPR011990; Transformation/transcription domain-associated protein (Tra1 homolog) Trrap Mus musculus (Mouse) TR31613_c2_g1_i1 Q8I8U7 TRA1_DROME 0 GO:0035267; GO:0000124; GO:0005737; GO:0016573; GO:0043486; GO:0005875; GO:0006909; GO:0016773; GO:0005703; GO:0045747; GO:0006355; GO:0006351; GO:0035222 "NuA4 histone acetyltransferase complex; SAGA complex; cytoplasm; histone acetylation; histone exchange; microtubule associated complex; phagocytosis; phosphotransferase activity, alcohol group as acceptor; polytene chromosome puff; positive regulation of Notch signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; wing disc pattern formation" IPR011989; IPR016024; IPR003152; IPR011009; IPR000403; IPR003151; IPR014009; Transcription-associated protein 1 (dTRA1) Nipped-A Tra1 CG2905 Drosophila melanogaster (Fruit fly) TR31613_c3_g1_i1 Q9Y4A5 TRRAP_HUMAN 7.00E-31 GO:0035267; GO:0000125; GO:0030914; GO:0043968; GO:0043967; GO:0016578; GO:0007093; GO:0016773; GO:0006355; GO:0003713; GO:0003712; GO:0033276; GO:0006351 O15265; P38398; P11474; P01106 "NuA4 histone acetyltransferase complex; PCAF complex; STAGA complex; histone H2A acetylation; histone H4 acetylation; histone deubiquitination; mitotic cell cycle checkpoint; phosphotransferase activity, alcohol group as acceptor; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription cofactor activity; transcription factor TFTC complex; transcription, DNA-dependent" IPR011989; IPR016024; IPR003152; IPR011009; IPR000403; IPR003151; IPR014009; IPR011990; Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) TRRAP PAF400 Homo sapiens (Human) TR31613_c4_g1_i1 Q80YV3 TRRAP_MOUSE 5.00E-30 GO:0035267; GO:0043968; GO:0043967; GO:0007093; GO:0016773; GO:0006355; GO:0003713; GO:0005667; GO:0006351 Q9JHD2 "NuA4 histone acetyltransferase complex; histone H2A acetylation; histone H4 acetylation; mitotic cell cycle checkpoint; phosphotransferase activity, alcohol group as acceptor; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription factor complex; transcription, DNA-dependent" IPR016024; IPR003152; IPR011009; IPR000403; IPR003151; IPR014009; IPR011990; Transformation/transcription domain-associated protein (Tra1 homolog) Trrap Mus musculus (Mouse) TR31615_c1_g1_i1 Q12852 M3K12_HUMAN 6.00E-121 GO:0005524; GO:0007254; GO:0004709; GO:0005829; GO:0030426; GO:0016572; GO:0018105; GO:0018107; GO:0005886; GO:0046777; GO:0042803; GO:0004674 Q70Z53 ATP binding; JNK cascade; MAP kinase kinase kinase activity; cytosol; growth cone; histone phosphorylation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; plasma membrane; protein autophosphorylation; protein homodimerization activity; protein serine/threonine kinase activity IPR011009; IPR017419; IPR027257; IPR000719; IPR001245; IPR008271; Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) MAP3K12 ZPK Homo sapiens (Human) TR31616_c1_g1_i1 Q0VFN8 CI117_XENTR 3.00E-60 Uncharacterized protein C9orf117 homolog Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31616_c1_g1_i2 Q4V7B0 CI117_RAT 4.00E-43 Uncharacterized protein C9orf117 homolog Rattus norvegicus (Rat) TR31616_c1_g1_i3 Q0VFN8 CI117_XENTR 2.00E-51 Uncharacterized protein C9orf117 homolog Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31617_c5_g2_i1 Q90578 VDHAP_CHICK 2.00E-28 GO:0016884; GO:0016811; GO:0005743 "carbon-nitrogen ligase activity, with glutamine as amido-N-donor; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; mitochondrial inner membrane" IPR000120; IPR020556; IPR023631; IPR015830; Vitamin D3 hydroxylase-associated protein (VDHAP) Gallus gallus (Chicken) TR31618_c2_g1_i1 Q8C2L6 T161B_MOUSE 3.00E-90 GO:0016021 integral to membrane IPR019395; Transmembrane protein 161B Tmem161b Mus musculus (Mouse) TR31620_c1_g3_i2 Q5R8C0 PPA6_PONAB 3.00E-08 GO:0003993; GO:0005576; GO:2001311; GO:0052642; GO:0005739 acid phosphatase activity; extracellular region; lysobisphosphatidic acid metabolic process; lysophosphatidic acid phosphatase activity; mitochondrion IPR000560; "Lysophosphatidic acid phosphatase type 6 (EC 3.1.3.2) (Acid phosphatase 6, lysophosphatidic)" ACP6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR31620_c1_g3_i3 Q0P5F0 PPAL_BOVIN 1.00E-72 GO:0003993; GO:0016021; GO:0043202; GO:0005765; GO:0007040; GO:0001501 acid phosphatase activity; integral to membrane; lysosomal lumen; lysosomal membrane; lysosome organization; skeletal system development IPR000560; Lysosomal acid phosphatase (LAP) (EC 3.1.3.2) ACP2 Bos taurus (Bovine) TR31623_c4_g1_i1 Q9BZF3 OSBL6_HUMAN 4.00E-104 GO:0005829; GO:0006869; GO:0031965; GO:0097038; GO:0005543; GO:0005886 Q9Q2G4 cytosol; lipid transport; nuclear membrane; perinuclear endoplasmic reticulum; phospholipid binding; plasma membrane IPR000648; IPR018494; IPR011993; IPR001849; Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) OSBPL6 ORP6 Homo sapiens (Human) TR31625_c1_g1_i1 Q3UYK3 TBCD9_MOUSE 8.00E-108 GO:0005097; GO:0005509; GO:0032851 Rab GTPase activator activity; calcium ion binding; positive regulation of Rab GTPase activity IPR011992; IPR002048; IPR004182; IPR000195; TBC1 domain family member 9 Tbc1d9 Kiaa0882 Mus musculus (Mouse) TR31626_c2_g2_i1 P40818 UBP8_HUMAN 3.00E-143 GO:0007265; GO:0001669; GO:0008283; GO:0004197; GO:0005829; GO:0005769; GO:0010008; GO:0007032; GO:0019897; GO:0030496; GO:0000281; GO:0005634; GO:0071108; GO:0070536; GO:0004221; GO:0006511; GO:0004843 Q9HD42; Q7LBR1; Q96CF2; Q14596 Ras protein signal transduction; acrosomal vesicle; cell proliferation; cysteine-type endopeptidase activity; cytosol; early endosome; endosome membrane; endosome organization; extrinsic to plasma membrane; midbody; mitotic cytokinesis; nucleus; protein K48-linked deubiquitination; protein K63-linked deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR018200; IPR001394; IPR001763; IPR015063; Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) USP8 KIAA0055 UBPY Homo sapiens (Human) TR31627_c1_g1_i1 Q9BX70 BTBD2_HUMAN 4.00E-36 GO:0000932 Q7L5N1; P04637 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) TR31627_c1_g1_i2 Q9BX70 BTBD2_HUMAN 2.00E-36 GO:0000932 Q7L5N1; P04637 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) TR3163_c0_g1_i1 Q9WV30 NFAT5_MOUSE 8.00E-23 GO:0003677; GO:0001816; GO:0005737; GO:0005634; GO:0045944; GO:0070884; GO:0003700; GO:0006351 "DNA binding; cytokine production; cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of calcineurin-NFAT signaling cascade; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR013783; IPR014756; IPR002909; IPR008366; IPR015646; IPR008967; IPR011539; Nuclear factor of activated T-cells 5 (NF-AT5) (Rel domain-containing transcription factor NFAT5) (T-cell transcription factor NFAT5) Nfat5 Mus musculus (Mouse) TR31631_c0_g1_i2 Q29PG4 RM51_DROPS 6.00E-19 GO:0005762; GO:0003735; GO:0006412 mitochondrial large ribosomal subunit; structural constituent of ribosome; translation IPR019373; "39S ribosomal protein L51, mitochondrial (L51mt) (MRP-L51)" mRpL51 GA12045 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR31633_c0_g1_i1 Q8MPM1 GELS2_LUMTE 5.00E-123 GO:0051693; GO:0005737; GO:0005856 actin filament capping; cytoplasm; cytoskeleton IPR007123; IPR007122; Gelsolin-like protein 2 (Actin-modulator) (EWAM-P2) gelsolin Lumbricus terrestris (Common earthworm) TR31635_c0_g1_i1 B4HT15 ASPG1_DROSE 3.00E-112 GO:0003948; GO:0005764; GO:0008233; GO:0006517; GO:0006508 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity; lysosome; peptidase activity; protein deglycosylation; proteolysis IPR000246; Putative N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase GM21137 (EC 3.5.1.26) (Aspartylglucosaminidase) (AGA) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain] GM21137 Drosophila sechellia (Fruit fly) TR31635_c0_g1_i3 Q5BKW9 ASGL1_DANRE 1.00E-10 GO:0003948; GO:0004067; GO:0033345; GO:0008798; GO:0005737; GO:0006508 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity; asparaginase activity; asparagine catabolic process via L-aspartate; beta-aspartyl-peptidase activity; cytoplasm; proteolysis IPR000246; Isoaspartyl peptidase/L-asparaginase (EC 3.4.19.5) (EC 3.5.1.1) (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain] asrgl1 zgc:103568 Danio rerio (Zebrafish) (Brachydanio rerio) TR31636_c0_g2_i2 O70244 CUBN_RAT 6.00E-10 GO:0031526; GO:0005509; GO:0008203; GO:0031419; GO:0030666; GO:0010008; GO:0030492; GO:0020028; GO:0042802; GO:0001701; GO:0043202; GO:0005765; GO:0043234; GO:0070207; GO:0004872; GO:0006898; GO:0007584; GO:0006766 Itself brush border membrane; calcium ion binding; cholesterol metabolic process; cobalamin binding; endocytic vesicle membrane; endosome membrane; hemoglobin binding; hemoglobin import; identical protein binding; in utero embryonic development; lysosomal lumen; lysosomal membrane; protein complex; protein homotrimerization; receptor activity; receptor-mediated endocytosis; response to nutrient; vitamin metabolic process IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; Cubilin (460 kDa receptor) (Glycoprotein 280) (gp280) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) Cubn Ifcr Rattus norvegicus (Rat) TR31637_c0_g1_i1 Q00614 CACP_CANTR 4.00E-48 GO:0004092; GO:0006631; GO:0005743; GO:0005777; GO:0006810 carnitine O-acetyltransferase activity; fatty acid metabolic process; mitochondrial inner membrane; peroxisome; transport IPR000542; "Carnitine O-acetyltransferase, mitochondrial (Carnitine acetylase) (EC 2.3.1.7)" CAT2 CAT Candida tropicalis (Yeast) TR31637_c0_g1_i3 P50416 CPT1A_HUMAN 0 GO:0004095; GO:0009437; GO:0006853; GO:0042755; GO:0006635; GO:0006006; GO:0031307; GO:0001676; GO:0005743; GO:0032000; GO:0051260; GO:0050796; GO:0042493; GO:0014070; GO:0006641 carnitine O-palmitoyltransferase activity; carnitine metabolic process; carnitine shuttle; eating behavior; fatty acid beta-oxidation; glucose metabolic process; integral to mitochondrial outer membrane; long-chain fatty acid metabolic process; mitochondrial inner membrane; positive regulation of fatty acid beta-oxidation; protein homooligomerization; regulation of insulin secretion; response to drug; response to organic cyclic compound; triglyceride metabolic process IPR000542; Lipid metabolism; fatty acid beta-oxidation. "Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A)" CPT1A CPT1 Homo sapiens (Human) TR31638_c0_g2_i1 B1AY10 NFX1_MOUSE 3.00E-99 GO:0003677; GO:0016874; GO:0045347; GO:0000122; GO:0005634; GO:0003700; GO:0006351; GO:0008270 "DNA binding; ligase activity; negative regulation of MHC class II biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR001374; IPR019786; IPR000967; IPR019787; IPR001841; "Transcriptional repressor NF-X1 (m-Nfx.1) (EC 6.3.2.-) (Nuclear transcription factor, X box-binding protein 1)" Nfx1 Mus musculus (Mouse) TR31638_c0_g3_i1 Q54BK0 NFX1_DICDI 4.00E-21 GO:0003677; GO:0000122; GO:0000166; GO:0005634; GO:0003700; GO:0006366; GO:0008270 DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleotide binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; zinc ion binding IPR012677; IPR019786; IPR000967; IPR019787; IPR001841; Transcriptional repressor NF-X1 homolog nfx1 DDB_G0293590 Dictyostelium discoideum (Slime mold) TR31638_c2_g1_i1 A6QLA0 NFX1_BOVIN 1.00E-73 GO:0003677; GO:0016874; GO:0045347; GO:0000122; GO:0005634; GO:0003700; GO:0006351; GO:0008270 "DNA binding; ligase activity; negative regulation of MHC class II biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR001374; IPR019786; IPR000967; IPR019787; IPR001841; "Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding protein 1)" NFX1 Bos taurus (Bovine) TR31639_c4_g1_i1 Q5SSH7 ZZEF1_MOUSE 1.00E-91 GO:0005509; GO:0008270 calcium ion binding; zinc ion binding IPR004939; IPR000859; IPR011992; IPR002048; IPR008979; IPR000433; Zinc finger ZZ-type and EF-hand domain-containing protein 1 Zzef1 Kiaa0399 Mus musculus (Mouse) TR31639_c4_g1_i3 Q14999 CUL7_HUMAN 4.00E-12 GO:0031467; GO:0005794; GO:0007030; GO:0006987; GO:0005680; GO:0044267; GO:0005829; GO:0019048; GO:0048471; GO:0050775; GO:0016567; GO:0006508; GO:0006511; GO:0001570 P04637 Cul7-RING ubiquitin ligase complex; Golgi apparatus; Golgi organization; activation of signaling protein activity involved in unfolded protein response; anaphase-promoting complex; cellular protein metabolic process; cytosol; modulation by virus of host morphology or physiology; perinuclear region of cytoplasm; positive regulation of dendrite morphogenesis; protein ubiquitination; proteolysis; ubiquitin-dependent protein catabolic process; vasculogenesis IPR004939; IPR016024; IPR021097; IPR016158; IPR001373; IPR008979; IPR014722; Protein modification; protein ubiquitination. Cullin-7 (CUL-7) CUL7 KIAA0076 Homo sapiens (Human) TR31640_c0_g1_i1 P11240 COX5A_RAT 2.00E-35 GO:0004129; GO:0046872; GO:0005743 cytochrome-c oxidase activity; metal ion binding; mitochondrial inner membrane IPR003204; "Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va)" Cox5a Rattus norvegicus (Rat) TR31640_c0_g1_i3 B0VYY5 COX5A_MACPM 2.00E-35 GO:0004129; GO:0046872; GO:0005743 cytochrome-c oxidase activity; metal ion binding; mitochondrial inner membrane IPR003204; "Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va)" COX5A Macropus parma (Parma wallaby) TR31640_c0_g1_i4 B0VYY5 COX5A_MACPM 2.00E-33 GO:0004129; GO:0046872; GO:0005743 cytochrome-c oxidase activity; metal ion binding; mitochondrial inner membrane IPR003204; "Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va)" COX5A Macropus parma (Parma wallaby) TR31642_c0_g1_i1 Q6UPE0 CHDH_RAT 1.00E-28 GO:0008812; GO:0050660; GO:0019285; GO:0005743 choline dehydrogenase activity; flavin adenine dinucleotide binding; glycine betaine biosynthetic process from choline; mitochondrial inner membrane IPR012132; IPR000172; IPR007867; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. "Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)" Chdh Rattus norvegicus (Rat) TR31642_c0_g2_i1 A5WA97 BETA_PSEP1 4.00E-23 GO:0008802; GO:0008812; GO:0050660; GO:0019285 betaine-aldehyde dehydrogenase activity; choline dehydrogenase activity; flavin adenine dinucleotide binding; glycine betaine biosynthetic process from choline IPR011533; IPR012132; IPR000172; IPR007867; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. Oxygen-dependent choline dehydrogenase (CDH) (CHD) (EC 1.1.99.1) (Betaine aldehyde dehydrogenase) (BADH) (EC 1.2.1.8) betA Pput_4937 Pseudomonas putida (strain F1 / ATCC 700007) TR31642_c0_g2_i2 C3K3D3 BETA_PSEFS 3.00E-22 GO:0008802; GO:0008812; GO:0050660; GO:0019285 betaine-aldehyde dehydrogenase activity; choline dehydrogenase activity; flavin adenine dinucleotide binding; glycine betaine biosynthetic process from choline IPR011533; IPR012132; IPR000172; IPR007867; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. Oxygen-dependent choline dehydrogenase (CDH) (CHD) (EC 1.1.99.1) (Betaine aldehyde dehydrogenase) (BADH) (EC 1.2.1.8) betA PFLU_5686 Pseudomonas fluorescens (strain SBW25) TR31645_c0_g1_i1 Q9JLR1 S61A2_MOUSE 0 GO:0005789; GO:0016021; GO:0015031; GO:0043022 endoplasmic reticulum membrane; integral to membrane; protein transport; ribosome binding IPR002208; IPR023201; IPR019561; Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha-2) Sec61a2 Mus musculus (Mouse) TR31646_c0_g1_i2 Q9QYM8 CENPH_MOUSE 1.00E-08 GO:0007059; GO:0000777; GO:0000776; GO:0051382; GO:0043515; GO:0051383; GO:0007067; GO:0005634 chromosome segregation; condensed chromosome kinetochore; kinetochore; kinetochore assembly; kinetochore binding; kinetochore organization; mitosis; nucleus IPR008426; Centromere protein H (CENP-H) Cenph Enp Mus musculus (Mouse) TR31647_c1_g1_i2 Q9QZC1 TRPC3_MOUSE 4.00E-06 GO:0005262; GO:0016021 calcium channel activity; integral to membrane IPR002110; IPR020683; IPR005821; IPR004729; IPR013555; IPR005459; IPR002153; Short transient receptor potential channel 3 (TrpC3) (Receptor-activated cation channel TRP3) (Transient receptor protein 3) (TRP-3) (mTrp3) (Trp-related protein 3) Trpc3 Trp3 Trrp3 Mus musculus (Mouse) TR31649_c0_g1_i1 P45961 CEX2_CAEEL 1.00E-20 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calexcitin-2 cex-2 T09A5.1 Caenorhabditis elegans TR31651_c1_g1_i4 P58195 PLS1_RAT 2.00E-60 GO:0042609; GO:0003677; GO:0005794; GO:0001077; GO:0017124; GO:0006915; GO:0005509; GO:0005829; GO:0051607; GO:0005154; GO:0031012; GO:0006955; GO:0005887; GO:0045121; GO:0045071; GO:0005730; GO:0017128; GO:2000373; GO:0045089; GO:0060368; GO:0033003 CD4 receptor binding; DNA binding; Golgi apparatus; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; SH3 domain binding; apoptotic process; calcium ion binding; cytosol; defense response to virus; epidermal growth factor receptor binding; extracellular matrix; immune response; integral to plasma membrane; membrane raft; negative regulation of viral genome replication; nucleolus; phospholipid scramblase activity; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity; positive regulation of innate immune response; regulation of Fc receptor mediated stimulatory signaling pathway; regulation of mast cell activation IPR005552; Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) Plscr1 Rattus norvegicus (Rat) TR31651_c1_g1_i6 Q3ZBG9 PLS2_BOVIN 3.00E-71 GO:0016021; GO:0046872 integral to membrane; metal ion binding IPR005552; Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) TR31651_c1_g1_i7 Q3ZBG9 PLS2_BOVIN 5.00E-59 GO:0016021; GO:0046872 integral to membrane; metal ion binding IPR005552; Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) TR31655_c0_g1_i1 Q810D6 GRWD1_MOUSE 1.00E-163 GO:0005737; GO:0005730 cytoplasm; nucleolus IPR020472; IPR022052; IPR015943; IPR001680; IPR019775; IPR017986; Glutamate-rich WD repeat-containing protein 1 (Protein A301) Grwd1 A301 Mus musculus (Mouse) TR31656_c0_g1_i2 Q8BZB2 COAC_MOUSE 5.00E-79 GO:0015937; GO:0004633 coenzyme A biosynthetic process; phosphopantothenoylcysteine decarboxylase activity IPR003382; Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5. Phosphopantothenoylcysteine decarboxylase (PPC-DC) (EC 4.1.1.36) (CoaC) Ppcdc Coac Mus musculus (Mouse) TR31656_c0_g1_i3 Q8BZB2 COAC_MOUSE 1.00E-78 GO:0015937; GO:0004633 coenzyme A biosynthetic process; phosphopantothenoylcysteine decarboxylase activity IPR003382; Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5. Phosphopantothenoylcysteine decarboxylase (PPC-DC) (EC 4.1.1.36) (CoaC) Ppcdc Coac Mus musculus (Mouse) TR31658_c0_g2_i1 A8XZB0 ATIF2_CAEBR 2.00E-20 GO:0004857; GO:0005739; GO:0043086; GO:0045980 enzyme inhibitor activity; mitochondrion; negative regulation of catalytic activity; negative regulation of nucleotide metabolic process IPR007648; "ATPase inhibitor mai-2, mitochondrial" mai-2 CBG21048 Caenorhabditis briggsae TR31659_c0_g1_i3 Q9CY16 RT28_MOUSE 3.00E-25 GO:0005739; GO:0005840 mitochondrion; ribosome IPR019375; IPR022967; "28S ribosomal protein S28, mitochondrial (MRP-S28) (S28mt)" Mrps28 Mus musculus (Mouse) TR31661_c10_g1_i1 Q9FR82 SLD1_BOROF 3.00E-14 GO:0006633; GO:0020037; GO:0016021; GO:0005506; GO:0016717; GO:0006665 "fatty acid biosynthetic process; heme binding; integral to membrane; iron ion binding; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; sphingolipid metabolic process" IPR001199; IPR012171; IPR005804; Delta(8)-fatty-acid desaturase (EC 1.14.19.4) (Delta(8)-sphingolipid desaturase) sld1 Borago officinalis (Bourrache) (Borage) TR31661_c12_g1_i1 Q3U1V8 M3K9_MOUSE 2.00E-87 GO:0005524; GO:0004709; GO:0000165; GO:0000186; GO:0006915; GO:0018108; GO:0004713; GO:0006355; GO:0006950; GO:0006351 "ATP binding; MAP kinase kinase kinase activity; MAPK cascade; activation of MAPKK activity; apoptotic process; peptidyl-tyrosine phosphorylation; protein tyrosine kinase activity; regulation of transcription, DNA-dependent; response to stress; transcription, DNA-dependent" IPR011009; IPR016231; IPR015785; IPR000719; IPR017441; IPR001245; IPR008271; IPR001452; IPR020635; Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) Map3k9 Mus musculus (Mouse) TR31661_c4_g1_i2 Q3U1V8 M3K9_MOUSE 9.00E-95 GO:0005524; GO:0004709; GO:0000165; GO:0000186; GO:0006915; GO:0018108; GO:0004713; GO:0006355; GO:0006950; GO:0006351 "ATP binding; MAP kinase kinase kinase activity; MAPK cascade; activation of MAPKK activity; apoptotic process; peptidyl-tyrosine phosphorylation; protein tyrosine kinase activity; regulation of transcription, DNA-dependent; response to stress; transcription, DNA-dependent" IPR011009; IPR016231; IPR015785; IPR000719; IPR017441; IPR001245; IPR008271; IPR001452; IPR020635; Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) Map3k9 Mus musculus (Mouse) TR31661_c4_g2_i1 O53510 PKNL_MYCTU 3.00E-12 GO:0005524; GO:0016021; GO:0045717; GO:0018107; GO:0005886; GO:0046777; GO:0004674 ATP binding; integral to membrane; negative regulation of fatty acid biosynthetic process; peptidyl-threonine phosphorylation; plasma membrane; protein autophosphorylation; protein serine/threonine kinase activity IPR011009; IPR000719; IPR008271; Serine/threonine-protein kinase PknL (EC 2.7.11.1) pknL Rv2176 MT2232 MTV021.09 Mycobacterium tuberculosis TR31661_c7_g1_i1 Q9SWQ9 SLD1_EUGGR 1.00E-08 GO:0006633; GO:0020037; GO:0016021; GO:0005506; GO:0016717; GO:0006665 "fatty acid biosynthetic process; heme binding; integral to membrane; iron ion binding; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; sphingolipid metabolic process" IPR001199; IPR012171; IPR005804; Delta(8)-fatty-acid desaturase (EC 1.14.19.4) (Delta(8)-sphingolipid desaturase) efd1 Euglena gracilis TR31661_c7_g2_i1 O60427 FADS1_HUMAN 6.00E-62 GO:0000248; GO:0007568; GO:0036109; GO:0019369; GO:0007267; GO:0009267; GO:0005789; GO:0020037; GO:0046456; GO:0016021; GO:0005506; GO:0043651; GO:0005739; GO:0005634; GO:0008654; GO:0045595; GO:0006355; GO:0032868; GO:0014070; GO:0009744; GO:0033189; GO:0006636 Q9UBM7; Q9BRP4 "C-5 sterol desaturase activity; aging; alpha-linolenic acid metabolic process; arachidonic acid metabolic process; cell-cell signaling; cellular response to starvation; endoplasmic reticulum membrane; heme binding; icosanoid biosynthetic process; integral to membrane; iron ion binding; linoleic acid metabolic process; mitochondrion; nucleus; phospholipid biosynthetic process; regulation of cell differentiation; regulation of transcription, DNA-dependent; response to insulin stimulus; response to organic cyclic compound; response to sucrose stimulus; response to vitamin A; unsaturated fatty acid biosynthetic process" IPR001199; IPR012171; IPR005804; Lipid metabolism; polyunsaturated fatty acid biosynthesis. Fatty acid desaturase 1 (EC 1.14.19.-) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase) FADS1 FADSD5 Homo sapiens (Human) TR31665_c1_g1_i4 P02637 SCP_MIZYE 2.00E-29 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Sarcoplasmic calcium-binding protein (SCP) Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) TR31666_c0_g1_i1 Q03017 CACT_DROME 1.00E-28 GO:0008063; GO:0019732; GO:0005737; GO:0042994; GO:0046843; GO:0009950; GO:0030097; GO:0045087; GO:0007399; GO:0031594; GO:0006909; GO:0006967; GO:0006974; GO:0008134 P15330; Q9VEZ5; Q9V393 Toll signaling pathway; antifungal humoral response; cytoplasm; cytoplasmic sequestering of transcription factor; dorsal appendage formation; dorsal/ventral axis specification; hemopoiesis; innate immune response; nervous system development; neuromuscular junction; phagocytosis; positive regulation of antifungal peptide biosynthetic process; response to DNA damage stimulus; transcription factor binding IPR002110; IPR020683; NF-kappa-B inhibitor cactus cact CG5848 Drosophila melanogaster (Fruit fly) TR31669_c2_g1_i1 P35292 RAB17_MOUSE 1.00E-40 GO:0019003; GO:0005525; GO:0016324; GO:0016323; GO:0030425; GO:0032456; GO:0046847; GO:0002415; GO:0042470; GO:0032402; GO:0043025; GO:0015031; GO:0055038; GO:0050773; GO:0051489; GO:0051963; GO:0007264 GDP binding; GTP binding; apical plasma membrane; basolateral plasma membrane; dendrite; endocytic recycling; filopodium assembly; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor; melanosome; melanosome transport; neuronal cell body; protein transport; recycling endosome membrane; regulation of dendrite development; regulation of filopodium assembly; regulation of synapse assembly; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-17 Rab17 Mus musculus (Mouse) TR31669_c2_g1_i2 P22129 RB11B_DISOM 7.00E-78 GO:0019003; GO:0005525; GO:0003924; GO:0030054; GO:0071468; GO:0045054; GO:0035773; GO:0032402; GO:0045335; GO:0030670; GO:0001881; GO:0055038; GO:0045055; GO:0044070; GO:2001135; GO:2000008; GO:1990126; GO:0007264; GO:0008021; GO:0030672; GO:0033572 "GDP binding; GTP binding; GTPase activity; cell junction; cellular response to acidity; constitutive secretory pathway; insulin secretion involved in cellular response to glucose stimulus; melanosome transport; phagocytic vesicle; phagocytic vesicle membrane; receptor recycling; recycling endosome membrane; regulated secretory pathway; regulation of anion transport; regulation of endocytic recycling; regulation of protein localization to cell surface; retrograde transport, endosome to plasma membrane; small GTPase mediated signal transduction; synaptic vesicle; synaptic vesicle membrane; transferrin transport" IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-11B (ORA3) Diplobatis ommata (Ocellated electric ray) (Discopyge ommata) TR31670_c0_g1_i1 Q8N8K9 K1958_HUMAN 1.00E-07 IPR021893; Uncharacterized protein KIAA1958 KIAA1958 Homo sapiens (Human) TR31675_c2_g1_i1 O88741 GDAP1_MOUSE 1.00E-10 GO:0031307; GO:0000266; GO:0006626; GO:0032526 integral to mitochondrial outer membrane; mitochondrial fission; protein targeting to mitochondrion; response to retinoic acid IPR010987; IPR004045; IPR012336; Ganglioside-induced differentiation-associated protein 1 (GDAP1) Gdap1 Mus musculus (Mouse) TR31676_c0_g2_i2 Q04791 SASB_ANAPL 9.00E-77 GO:0006633; GO:0016787 fatty acid biosynthetic process; hydrolase activity IPR002018; IPR019826; IPR019819; "Fatty acyl-CoA hydrolase precursor, medium chain (EC 3.1.2.-) (Thioesterase B)" Anas platyrhynchos (Domestic duck) (Anas boschas) TR31677_c0_g2_i1 Q6QAJ8 TM220_HUMAN 8.00E-10 GO:0016021 integral to membrane Transmembrane protein 220 TMEM220 Homo sapiens (Human) TR3168_c0_g1_i1 Q8R081 HNRPL_MOUSE 2.00E-35 GO:0003723; GO:0005737; GO:0006397; GO:0005654; GO:0000166; GO:0045120; GO:0030529; GO:0044212 RNA binding; cytoplasm; mRNA processing; nucleoplasm; nucleotide binding; pronucleus; ribonucleoprotein complex; transcription regulatory region DNA binding IPR006536; IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein L (hnRNP L) Hnrnpl Hnrpl Mus musculus (Mouse) TR31680_c0_g1_i1 Q96RW7 HMCN1_HUMAN 4.00E-56 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR31684_c2_g1_i2 P55214 CASP7_MESAU 5.00E-17 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR015471; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; "Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11; Caspase-7, N-terminally processed]" CASP7 MCH3 Mesocricetus auratus (Golden hamster) TR31684_c3_g1_i2 Q98943 CASP2_CHICK 1.00E-11 GO:0006915; GO:0004197; GO:0005622; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; intracellular; proteolysis; regulation of apoptotic process IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) TR31684_c3_g1_i5 P42574 CASP3_HUMAN 7.00E-21 GO:0001782; GO:0043029; GO:0008635; GO:0006309; GO:0004190; GO:0045165; GO:0004861; GO:0004197; GO:0005829; GO:0008625; GO:0007507; GO:0035329; GO:0097193; GO:0008631; GO:0030216; GO:0005739; GO:0030889; GO:0046007; GO:0043066; GO:0045736; GO:0051402; GO:0048011; GO:0030264; GO:0005654; GO:0005886; GO:0043065; GO:0043525; GO:0016485; GO:0006508; GO:0001836; GO:0006974; GO:0009411; GO:0034612; GO:0009611; GO:0007605 Q9BYP7 B cell homeostasis; T cell homeostasis; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; apoptotic DNA fragmentation; aspartic-type endopeptidase activity; cell fate commitment; cyclin-dependent protein serine/threonine kinase inhibitor activity; cysteine-type endopeptidase activity; cytosol; extrinsic apoptotic signaling pathway via death domain receptors; heart development; hippo signaling cascade; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to oxidative stress; keratinocyte differentiation; mitochondrion; negative regulation of B cell proliferation; negative regulation of activated T cell proliferation; negative regulation of apoptotic process; negative regulation of cyclin-dependent protein serine/threonine kinase activity; neuron apoptotic process; neurotrophin TRK receptor signaling pathway; nuclear fragmentation involved in apoptotic nuclear change; nucleoplasm; plasma membrane; positive regulation of apoptotic process; positive regulation of neuron apoptotic process; protein processing; proteolysis; release of cytochrome c from mitochondria; response to DNA damage stimulus; response to UV; response to tumor necrosis factor; response to wounding; sensory perception of sound IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 CPP32 Homo sapiens (Human) TR31684_c3_g1_i8 P55865 CAS1A_XENLA 3.00E-08 GO:0006915; GO:0004197; GO:0005737; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis; regulation of apoptotic process IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-1-A (CASP-1-A) (EC 3.4.22.36) (Interleukin-1 beta convertase homolog A) (xICE-A) casp1-a casp1a Xenopus laevis (African clawed frog) TR31684_c4_g1_i1 P97864 CASP7_MOUSE 1.00E-08 GO:0004190; GO:0097153; GO:0005737; GO:0097194; GO:0007507; GO:0005634; GO:0043525; GO:0016485; GO:0006508; GO:0001836; GO:0009411 P11103; P62270 aspartic-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cytoplasm; execution phase of apoptosis; heart development; nucleus; positive regulation of neuron apoptotic process; protein processing; proteolysis; release of cytochrome c from mitochondria; response to UV IPR015471; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; "Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11; Caspase-7, N-terminally processed]" Casp7 Lice2 Mch3 Mus musculus (Mouse) TR31685_c1_g1_i1 Q6NUB3 S22AF_XENLA 6.00E-28 GO:0016021; GO:0006811; GO:0022857 integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Solute carrier family 22 member 15 slc22a15 Xenopus laevis (African clawed frog) TR31685_c1_g1_i3 Q9VCA2 ORCT_DROME 2.00E-81 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR31689_c0_g1_i1 Q6L6Q6 LYS_CRAGI 4.00E-32 GO:0019835; GO:0042742; GO:0005576; GO:0003796 cytolysis; defense response to bacterium; extracellular region; lysozyme activity IPR008597; IPR023346; "Lysozyme (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase)" lysoz Crassostrea gigas (Pacific oyster) (Crassostrea angulata) TR31689_c0_g1_i2 Q6L6Q5 LYS_OSTED 3.00E-28 GO:0019835; GO:0042742; GO:0005576; GO:0003796 cytolysis; defense response to bacterium; extracellular region; lysozyme activity IPR008597; IPR023346; "Lysozyme (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase)" lysoz Ostrea edulis (Native oyster) (European flat oyster) TR31689_c0_g1_i3 Q6L6Q6 LYS_CRAGI 3.00E-32 GO:0019835; GO:0042742; GO:0005576; GO:0003796 cytolysis; defense response to bacterium; extracellular region; lysozyme activity IPR008597; IPR023346; "Lysozyme (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase)" lysoz Crassostrea gigas (Pacific oyster) (Crassostrea angulata) TR31690_c2_g1_i2 Q652Q8 URH2_ORYSJ 4.00E-35 GO:0005737; GO:0045437 cytoplasm; uridine nucleosidase activity IPR023186; IPR001910; Probable uridine nucleosidase 2 (EC 3.2.2.3) (Uridine ribohydrolase 2) URH2 Os09g0567900 LOC_Os09g39440 OJ1003_C09.5 OsJ_30393 Oryza sativa subsp. japonica (Rice) TR31690_c2_g1_i3 Q6ZJ05 URH1_ORYSJ 1.00E-33 GO:0005737; GO:0045437 cytoplasm; uridine nucleosidase activity IPR023186; IPR001910; Probable uridine nucleosidase 1 (EC 3.2.2.3) (Uridine ribohydrolase 1) URH1 Os08g0557900 LOC_Os08g44370 OJ1150_A11.30 OsJ_28263 Oryza sativa subsp. japonica (Rice) TR31692_c0_g2_i1 Q15751 HERC1_HUMAN 3.00E-118 GO:0005086; GO:0005794; GO:0021702; GO:0005829; GO:0016020; GO:0010507; GO:0050885; GO:0031175; GO:0006810; GO:0004842 ARF guanyl-nucleotide exchange factor activity; Golgi apparatus; cerebellar Purkinje cell differentiation; cytosol; membrane; negative regulation of autophagy; neuromuscular process controlling balance; neuron projection development; transport; ubiquitin-protein ligase activity IPR001870; IPR008985; IPR000569; IPR009091; IPR000408; IPR018355; IPR003877; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HERC1 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 1) (p532) (p619) HERC1 Homo sapiens (Human) TR31693_c7_g1_i1 Q58D31 DHSO_BOVIN 3.00E-132 GO:0003939; GO:0051160; GO:0051287; GO:0046370; GO:0031966; GO:0031514; GO:0006062; GO:0030317; GO:0008270 L-iditol 2-dehydrogenase activity; L-xylitol catabolic process; NAD binding; fructose biosynthetic process; mitochondrial membrane; motile cilium; sorbitol catabolic process; sperm motility; zinc ion binding IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase) SORD Bos taurus (Bovine) TR31694_c0_g1_i1 Q53533 SAV2_STRVL 8.00E-16 GO:0005576 extracellular region IPR005469; IPR017889; IPR005468; Streptavidin-V2 (SA V2) Streptomyces violaceus (Streptomyces venezuelae) TR31696_c0_g1_i1 P13994 CC130_HUMAN 1.00E-103 GO:0009615 P49910 response to virus IPR007590; Coiled-coil domain-containing protein 130 (9 kDa protein) CCDC130 SB115 Homo sapiens (Human) TR31697_c1_g1_i1 Q96MM6 HS12B_HUMAN 5.00E-87 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR31698_c1_g2_i1 Q5M875 DHB13_RAT 7.00E-71 GO:0005576; GO:0016491 extracellular region; oxidoreductase activity IPR002198; IPR002347; IPR016040; 17-beta-hydroxysteroid dehydrogenase 13 (17-beta-HSD 13) (EC 1.1.-.-) (Short-chain dehydrogenase/reductase 9) Hsd17b13 Scdr9 Rattus norvegicus (Rat) TR31698_c1_g2_i2 Q8N3Y7 RDHE2_HUMAN 5.00E-96 GO:0050908; GO:0005789; GO:0016021; GO:0043616; GO:0042574; GO:0004745; GO:0042572 detection of light stimulus involved in visual perception; endoplasmic reticulum membrane; integral to membrane; keratinocyte proliferation; retinal metabolic process; retinol dehydrogenase activity; retinol metabolic process IPR002198; IPR002347; IPR016040; Cofactor metabolism; retinol metabolism. Epidermal retinol dehydrogenase 2 (EPHD-2) (RDH-E2) (EC 1.1.1.105) (Retinal short-chain dehydrogenase reductase 2) (retSDR2) (Short-chain dehydrogenase/reductase family 16C member 5) SDR16C5 RDHE2 Homo sapiens (Human) TR31698_c1_g2_i3 Q8N3Y7 RDHE2_HUMAN 5.00E-96 GO:0050908; GO:0005789; GO:0016021; GO:0043616; GO:0042574; GO:0004745; GO:0042572 detection of light stimulus involved in visual perception; endoplasmic reticulum membrane; integral to membrane; keratinocyte proliferation; retinal metabolic process; retinol dehydrogenase activity; retinol metabolic process IPR002198; IPR002347; IPR016040; Cofactor metabolism; retinol metabolism. Epidermal retinol dehydrogenase 2 (EPHD-2) (RDH-E2) (EC 1.1.1.105) (Retinal short-chain dehydrogenase reductase 2) (retSDR2) (Short-chain dehydrogenase/reductase family 16C member 5) SDR16C5 RDHE2 Homo sapiens (Human) TR31698_c1_g2_i4 P50941 FABG_RICPR 2.00E-20 GO:0004316; GO:0051287; GO:0050661; GO:0030497 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NAD binding; NADP binding; fatty acid elongation IPR011284; IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) (Beta-Ketoacyl-acyl carrier protein reductase) (Beta-ketoacyl-ACP reductase) fabG RP762 Rickettsia prowazekii (strain Madrid E) TR31698_c1_g2_i6 Q5M875 DHB13_RAT 7.00E-71 GO:0005576; GO:0016491 extracellular region; oxidoreductase activity IPR002198; IPR002347; IPR016040; 17-beta-hydroxysteroid dehydrogenase 13 (17-beta-HSD 13) (EC 1.1.-.-) (Short-chain dehydrogenase/reductase 9) Hsd17b13 Scdr9 Rattus norvegicus (Rat) TR31700_c0_g1_i1 Q91ZV7 PLDX1_MOUSE 2.00E-54 GO:0005737; GO:0016021; GO:0007275; GO:0005886; GO:0004872; GO:0005923 P08460 cytoplasm; integral to membrane; multicellular organismal development; plasma membrane; receptor activity; tight junction IPR016201; IPR002165; Plexin domain-containing protein 1 (Tumor endothelial marker 7) Plxdc1 Tem7 Mus musculus (Mouse) TR31700_c0_g1_i3 Q91ZV7 PLDX1_MOUSE 1.00E-55 GO:0005737; GO:0016021; GO:0007275; GO:0005886; GO:0004872; GO:0005923 P08460 cytoplasm; integral to membrane; multicellular organismal development; plasma membrane; receptor activity; tight junction IPR016201; IPR002165; Plexin domain-containing protein 1 (Tumor endothelial marker 7) Plxdc1 Tem7 Mus musculus (Mouse) TR31701_c1_g2_i1 P62810 EXPI_MOUSE 6.00E-07 GO:0005576; GO:0030414 extracellular region; peptidase inhibitor activity IPR008197; WAP four-disulfide core domain protein 18 (Extracellular peptidase inhibitor) (Protein WDNM1) Wfdc18 Expi Wdnm1 Mus musculus (Mouse) TR31701_c3_g1_i1 Q9NJ15 PCSK5_BRACL 5.00E-23 GO:0005576; GO:0016021; GO:0005886; GO:0006508; GO:0004252 extracellular region; integral to membrane; plasma membrane; proteolysis; serine-type endopeptidase activity IPR000742; IPR006212; IPR008979; IPR009030; IPR000209; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase PC6-like) (aPC6) PC6 Branchiostoma californiense (California lancelet) (Amphioxus) TR31701_c5_g2_i2 Q80ZF8 BAI3_MOUSE 7.00E-07 GO:0004930; GO:0016021; GO:0016525; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; negative regulation of angiogenesis; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR008077; IPR001879; IPR000832; IPR017983; IPR000203; IPR000884; Brain-specific angiogenesis inhibitor 3 Bai3 Mus musculus (Mouse) TR31701_c5_g2_i4 P33005 KALM_CHICK 1.00E-07 GO:0007155; GO:0009986; GO:0005576; GO:0004867 cell adhesion; cell surface; extracellular region; serine-type endopeptidase inhibitor activity IPR003961; IPR013783; IPR008197; Anosmin-1 (Kallmann syndrome protein homolog) KAL1 KAL Gallus gallus (Chicken) TR31701_c5_g2_i5 Q9NJ15 PCSK5_BRACL 1.00E-20 GO:0005576; GO:0016021; GO:0005886; GO:0006508; GO:0004252 extracellular region; integral to membrane; plasma membrane; proteolysis; serine-type endopeptidase activity IPR000742; IPR006212; IPR008979; IPR009030; IPR000209; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase PC6-like) (aPC6) PC6 Branchiostoma californiense (California lancelet) (Amphioxus) TR31701_c7_g1_i1 P13134 KEX2_YEAST 2.00E-24 GO:0005794; GO:0016021; GO:0046872; GO:0007323; GO:0006508; GO:0004252; GO:0005802 P32790 Golgi apparatus; integral to membrane; metal ion binding; peptide pheromone maturation; proteolysis; serine-type endopeptidase activity; trans-Golgi network IPR008979; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR002884; Kexin (EC 3.4.21.61) (Protease KEX2) (Proteinase YSCF) KEX2 QDS1 YNL238W N1122 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR31701_c7_g1_i3 P09231 KEX1A_KLULA 3.00E-23 GO:0016021; GO:0006508; GO:0004252 integral to membrane; proteolysis; serine-type endopeptidase activity IPR008979; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR002884; Protease KEX1 (EC 3.4.21.-) KEX1 KLLA0D19811g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR31701_c7_g2_i1 P29119 FURI1_XENLA 2.00E-20 GO:0016021; GO:0006508; GO:0004252 integral to membrane; proteolysis; serine-type endopeptidase activity IPR006212; IPR008979; IPR009030; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Furin-1 (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE) furin Xenopus laevis (African clawed frog) TR31701_c8_g1_i1 Q8IUB2 WFDC3_HUMAN 6.00E-13 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR008197; WAP four-disulfide core domain protein 3 (Putative protease inhibitor WAP14) WFDC3 WAP14 Homo sapiens (Human) TR31704_c2_g1_i1 Q8IV35 WDR49_HUMAN 1.00E-63 IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 49 WDR49 Homo sapiens (Human) TR31706_c0_g2_i2 P95607 CATA_RHOOP 6.00E-08 GO:0019439; GO:0018576; GO:0009712; GO:0008199 "aromatic compound catabolic process; catechol 1,2-dioxygenase activity; catechol-containing compound metabolic process; ferric iron binding" IPR007535; IPR012800; IPR000627; IPR015889; "Catechol 1,2-dioxygenase (EC 1.13.11.1) (1,2-CTD) (Fragment)" catA Rhodococcus opacus (Nocardia opaca) TR31707_c1_g1_i1 Q9NV72 ZN701_HUMAN 2.00E-24 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 701 ZNF701 Homo sapiens (Human) TR31707_c4_g1_i1 Q9QX96 SALL2_MOUSE 3.00E-06 GO:0003677; GO:0046872; GO:0000122; GO:0021915; GO:0005634; GO:0006351 "DNA binding; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; neural tube development; nucleus; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Sal-like protein 2 (Spalt-like protein 2) (Zinc finger protein Spalt-2) (Sal-2) (mSal-2) Sall2 Sal2 Mus musculus (Mouse) TR31710_c2_g1_i2 Q2M1D1 UFSP2_DROPS 1.00E-41 GO:0006508; GO:0019783; GO:0016790 proteolysis; small conjugating protein-specific protease activity; thiolester hydrolase activity IPR012462; Probable Ufm1-specific protease 2 (UfSP2) (EC 3.4.22.-) UFSP2 GA14252 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR31710_c2_g1_i3 Q6NVU6 UFSP1_HUMAN 3.00E-22 GO:0071567; GO:0016790 UFM1 hydrolase activity; thiolester hydrolase activity IPR012462; Inactive Ufm1-specific protease 1 (UfSP1) UFSP1 Homo sapiens (Human) TR31710_c2_g1_i4 Q9CZP0 UFSP1_MOUSE 2.00E-50 GO:0071567; GO:0006508; GO:0016790 UFM1 hydrolase activity; proteolysis; thiolester hydrolase activity IPR012462; Ufm1-specific protease 1 (UfSP1) (EC 3.4.22.-) Ufsp1 D5Ertd655e Mus musculus (Mouse) TR31711_c2_g1_i1 Q9NXG0 CNTLN_HUMAN 2.00E-27 GO:0005814; GO:0005813; GO:0016020; GO:0005739; GO:0000155; GO:0000160; GO:0023014 centriole; centrosome; membrane; mitochondrion; phosphorelay sensor kinase activity; phosphorelay signal transduction system; signal transduction by phosphorylation IPR003661; Centlein (Centrosomal protein) CNTLN C9orf101 C9orf39 Homo sapiens (Human) TR31713_c0_g1_i1 P29094 O16G_BACTR 7.00E-37 GO:0005975; GO:0043169; GO:0005737; GO:0004574 "carbohydrate metabolic process; cation binding; cytoplasm; oligo-1,6-glucosidase activity" IPR015902; IPR013780; IPR006047; IPR006589; IPR013781; IPR017853; "Oligo-1,6-glucosidase (EC 3.2.1.10) (Dextrin 6-alpha-D-glucanohydrolase) (Oligosaccharide alpha-1,6-glucosidase) (Sucrase-isomaltase) (Isomaltase)" malL Geobacillus thermoglucosidasius (Bacillus thermoglucosidasius) TR31713_c0_g2_i1 Q64319 SLC31_RAT 7.00E-51 GO:0006865; GO:0005975; GO:0003824; GO:0043169; GO:0005887; GO:0046982; GO:0005774 amino acid transport; carbohydrate metabolic process; catalytic activity; cation binding; integral to plasma membrane; protein heterodimerization activity; vacuolar membrane IPR015902; IPR006047; IPR006589; IPR013781; IPR017853; "Neutral and basic amino acid transport protein rBAT (B(0,+)-type amino acid transport protein) (NAA-TR) (D2) (Solute carrier family 3 member 1)" Slc3a1 Nbat Rattus norvegicus (Rat) TR31713_c0_g2_i2 Q64319 SLC31_RAT 2.00E-39 GO:0006865; GO:0005975; GO:0003824; GO:0043169; GO:0005887; GO:0046982; GO:0005774 amino acid transport; carbohydrate metabolic process; catalytic activity; cation binding; integral to plasma membrane; protein heterodimerization activity; vacuolar membrane IPR015902; IPR006047; IPR006589; IPR013781; IPR017853; "Neutral and basic amino acid transport protein rBAT (B(0,+)-type amino acid transport protein) (NAA-TR) (D2) (Solute carrier family 3 member 1)" Slc3a1 Nbat Rattus norvegicus (Rat) TR31714_c7_g1_i1 Q9BXT4 TDRD1_HUMAN 2.00E-27 GO:0043046; GO:0033391; GO:0031047; GO:0007281; GO:0007126; GO:0046872; GO:0007275; GO:0071546; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; chromatoid body; gene silencing by RNA; germ cell development; meiosis; metal ion binding; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002999; IPR002893; Tudor domain-containing protein 1 (Cancer/testis antigen 41.1) (CT41.1) TDRD1 Homo sapiens (Human) TR31714_c7_g1_i2 Q58EK5 TDRD1_DANRE 4.00E-24 GO:0043046; GO:0031047; GO:0007281; GO:0007126; GO:0046872; GO:0007275; GO:0071546; GO:0034587; GO:0007283 Q8UVX0; A2CEI6 DNA methylation involved in gamete generation; gene silencing by RNA; germ cell development; meiosis; metal ion binding; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002999; IPR002893; Tudor domain-containing protein 1 tdrd1 im:7155161 Danio rerio (Zebrafish) (Brachydanio rerio) TR31715_c0_g1_i1 Q8R035 ICT1_MOUSE 7.00E-28 GO:0004045; GO:0005762; GO:0070126; GO:0016150 "aminoacyl-tRNA hydrolase activity; mitochondrial large ribosomal subunit; mitochondrial translational termination; translation release factor activity, codon nonspecific" IPR000352; "Peptidyl-tRNA hydrolase ICT1, mitochondrial (EC 3.1.1.29) (39S ribosomal protein L58, mitochondrial) (MRP-L58) (Immature colon carcinoma transcript 1 protein homolog)" Ict1 Mrpl58 Mus musculus (Mouse) TR31715_c0_g1_i3 Q8R035 ICT1_MOUSE 7.00E-28 GO:0004045; GO:0005762; GO:0070126; GO:0016150 "aminoacyl-tRNA hydrolase activity; mitochondrial large ribosomal subunit; mitochondrial translational termination; translation release factor activity, codon nonspecific" IPR000352; "Peptidyl-tRNA hydrolase ICT1, mitochondrial (EC 3.1.1.29) (39S ribosomal protein L58, mitochondrial) (MRP-L58) (Immature colon carcinoma transcript 1 protein homolog)" Ict1 Mrpl58 Mus musculus (Mouse) TR31718_c1_g1_i4 Q28G67 F206A_XENTR 4.00E-50 GO:0006546; GO:0005960 glycine catabolic process; glycine cleavage complex IPR002930; IPR011053; Protein FAM206A fam206a TGas009a04.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31719_c1_g3_i1 Q8T880 AXP83_CIOIN 1.00E-62 IPR023247; IPR022110; Axonemal 84 kDa protein (Ci-AXP83.9) (p83.9) AXP83.9 Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) TR3172_c0_g1_i1 Q5R7G9 NUAK2_PONAB 1.00E-06 GO:0005524; GO:0030036; GO:0006915; GO:0042149; GO:0000287; GO:0043066; GO:0004674 ATP binding; actin cytoskeleton organization; apoptotic process; cellular response to glucose starvation; magnesium ion binding; negative regulation of apoptotic process; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; NUAK family SNF1-like kinase 2 (EC 2.7.11.1) NUAK2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR31723_c0_g3_i1 Q24048 ATPB2_DROME 3.00E-50 GO:0006812; GO:0061343; GO:0060857; GO:0006813; GO:0035158; GO:0035159; GO:0007605; GO:0005918; GO:0019991; GO:0006814; GO:0005890 "cation transport; cell adhesion involved in heart morphogenesis; establishment of glial blood-brain barrier; potassium ion transport; regulation of tube diameter, open tracheal system; regulation of tube length, open tracheal system; sensory perception of sound; septate junction; septate junction assembly; sodium ion transport; sodium:potassium-exchanging ATPase complex" IPR000402; Sodium/potassium-transporting ATPase subunit beta-2 (Protein nervana 2) (Sodium/potassium-dependent ATPase subunit beta-2) nrv2 CG9261 Drosophila melanogaster (Fruit fly) TR31723_c1_g1_i1 Q93235 AT1B1_CAEEL 3.00E-54 GO:0006813; GO:0006814; GO:0005890 potassium ion transport; sodium ion transport; sodium:potassium-exchanging ATPase complex IPR000402; Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1) nkb-1 C17E4.9 Caenorhabditis elegans TR31723_c1_g1_i2 Q24046 ATPB1_DROME 1.00E-34 GO:0006812; GO:0006813; GO:0006814; GO:0005890 cation transport; potassium ion transport; sodium ion transport; sodium:potassium-exchanging ATPase complex IPR000402; Sodium/potassium-transporting ATPase subunit beta-1 (Protein nervana 1) (Sodium/potassium-dependent ATPase subunit beta-1) nrv1 CG9258 Drosophila melanogaster (Fruit fly) TR31723_c1_g1_i4 Q93235 AT1B1_CAEEL 4.00E-54 GO:0006813; GO:0006814; GO:0005890 potassium ion transport; sodium ion transport; sodium:potassium-exchanging ATPase complex IPR000402; Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1) nkb-1 C17E4.9 Caenorhabditis elegans TR31724_c1_g1_i4 Q5D013 MET10_DANRE 7.00E-71 GO:0008168 methyltransferase activity IPR025714; IPR026635; Methyltransferase-like protein 10 (EC 2.1.1.-) mettl10 zgc:110805 Danio rerio (Zebrafish) (Brachydanio rerio) TR31724_c1_g1_i5 A1KG37 Y605_MYCBP 3.00E-06 GO:0005737 cytoplasm IPR025714; Uncharacterized protein BCG_0605c BCG_0605c Mycobacterium bovis (strain BCG / Pasteur 1173P2) TR31725_c0_g1_i1 P86220 PHB_MESAU 2.00E-23 GO:0006260; GO:0005743 DNA replication; mitochondrial inner membrane IPR000163; Prohibitin (Fragments) PHB Mesocricetus auratus (Golden hamster) TR31725_c0_g1_i2 P67779 PHB_RAT 6.00E-134 GO:0006260; GO:0031315; GO:0030061; GO:0043066; GO:0008285; GO:0005634; GO:0031100; GO:0001552; GO:0001541; GO:0034097; GO:0042493; GO:0045471; GO:0043434 DNA replication; extrinsic to mitochondrial outer membrane; mitochondrial crista; negative regulation of apoptotic process; negative regulation of cell proliferation; nucleus; organ regeneration; ovarian follicle atresia; ovarian follicle development; response to cytokine stimulus; response to drug; response to ethanol; response to peptide hormone stimulus IPR001107; IPR000163; Prohibitin Phb Rattus norvegicus (Rat) TR31725_c0_g1_i3 Q9BKU4 PHB1_CAEEL 2.00E-123 GO:0030421; GO:0009792; GO:0008406; GO:0035632; GO:0070584; GO:0048477; GO:0040018; GO:0002082; GO:0043051; GO:0006979; GO:0007283 defecation; embryo development ending in birth or egg hatching; gonad development; mitochondrial prohibitin complex; mitochondrion morphogenesis; oogenesis; positive regulation of multicellular organism growth; regulation of oxidative phosphorylation; regulation of pharyngeal pumping; response to oxidative stress; spermatogenesis IPR001107; IPR000163; Mitochondrial prohibitin complex protein 1 (Prohibitin-1) phb-1 Y37E3.9 Caenorhabditis elegans TR31730_c0_g1_i2 Q9VE46 SC5A7_DROME 8.00E-107 GO:0008292; GO:0015171; GO:0015220; GO:0016021; GO:0006814; GO:0015293 acetylcholine biosynthetic process; amino acid transmembrane transporter activity; choline transmembrane transporter activity; integral to membrane; sodium ion transport; symporter activity IPR001734; High-affinity choline transporter 1 CG7708 Drosophila melanogaster (Fruit fly) TR31730_c0_g1_i6 Q9VE46 SC5A7_DROME 3.00E-125 GO:0008292; GO:0015171; GO:0015220; GO:0016021; GO:0006814; GO:0015293 acetylcholine biosynthetic process; amino acid transmembrane transporter activity; choline transmembrane transporter activity; integral to membrane; sodium ion transport; symporter activity IPR001734; High-affinity choline transporter 1 CG7708 Drosophila melanogaster (Fruit fly) TR31732_c0_g1_i2 Q8TEB9 RHBL4_HUMAN 1.00E-65 GO:0030433; GO:0006915; GO:0034644; GO:0034620; GO:0044322; GO:0030176; GO:0031293; GO:0033619; GO:0005739; GO:0043066; GO:0045732; GO:0010954; GO:0051047; GO:0043687; GO:0004252; GO:0048515 ER-associated protein catabolic process; apoptotic process; cellular response to UV; cellular response to unfolded protein; endoplasmic reticulum quality control compartment; integral to endoplasmic reticulum membrane; membrane protein intracellular domain proteolysis; membrane protein proteolysis; mitochondrion; negative regulation of apoptotic process; positive regulation of protein catabolic process; positive regulation of protein processing; positive regulation of secretion; post-translational protein modification; serine-type endopeptidase activity; spermatid differentiation IPR022764; Rhomboid-related protein 4 (RRP4) (EC 3.4.21.105) (Rhomboid domain-containing protein 1) (Rhomboid-like protein 4) RHBDD1 RHBDL4 HSD-50 HSD50 Homo sapiens (Human) TR31735_c1_g3_i1 Q8MQJ9 BRAT_DROME 0 GO:0008356; GO:0055060; GO:0007411; GO:0007420; GO:0005737; GO:0007402; GO:0007406; GO:0048477; GO:0006909; GO:0009303; GO:0035282; GO:0030371; GO:0008270 asymmetric cell division; asymmetric neuroblast division resulting in ganglion mother cell formation; axon guidance; brain development; cytoplasm; ganglion mother cell fate determination; negative regulation of neuroblast proliferation; oogenesis; phagocytosis; rRNA transcription; segmentation; translation repressor activity; zinc ion binding IPR011042; IPR001258; IPR013017; IPR000315; Brain tumor protein brat CG10719 Drosophila melanogaster (Fruit fly) TR31736_c3_g1_i1 Q5RAP9 AT5G2_PONAB 9.00E-33 GO:0015991; GO:0015986; GO:0015078; GO:0016021; GO:0008289; GO:0031966; GO:0045263 "ATP hydrolysis coupled proton transport; ATP synthesis coupled proton transport; hydrogen ion transmembrane transporter activity; integral to membrane; lipid binding; mitochondrial membrane; proton-transporting ATP synthase complex, coupling factor F(o)" IPR000454; IPR020537; IPR002379; "ATP synthase F(0) complex subunit C2, mitochondrial (ATP synthase lipid-binding protein) (ATP synthase proteolipid P2) (ATPase protein 9) (ATPase subunit c)" ATP5G2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR31738_c0_g1_i3 Q8CH18 CCAR1_MOUSE 1.00E-118 GO:0006915; GO:0007049; GO:0030374; GO:0003676; GO:0048471; GO:0006355; GO:0006351 "apoptotic process; cell cycle; ligand-dependent nuclear receptor transcription coactivator activity; nucleic acid binding; perinuclear region of cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025224; IPR025954; IPR025223; IPR003034; Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) Ccar1 Carp1 Mus musculus (Mouse) TR31739_c0_g1_i3 Q6AXQ2 EFC11_RAT 2.00E-31 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; EF-hand calcium-binding domain-containing protein 11 Efcab11 Rattus norvegicus (Rat) TR31739_c0_g1_i7 Q6AXQ2 EFC11_RAT 4.00E-33 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; EF-hand calcium-binding domain-containing protein 11 Efcab11 Rattus norvegicus (Rat) TR31739_c0_g1_i8 O97341 CALM_SUBDO 2.00E-11 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) Suberites domuncula (Sponge) TR31743_c0_g2_i1 Q6AZB8 HARB1_DANRE 1.00E-29 GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) TR31745_c0_g1_i1 P41564 IDH3G_MACFA 1.00E-140 GO:0005524; GO:0051287; GO:0004449; GO:0006102; GO:0000287; GO:0005739; GO:0006099 ATP binding; NAD binding; isocitrate dehydrogenase (NAD+) activity; isocitrate metabolic process; magnesium ion binding; mitochondrion; tricarboxylic acid cycle IPR019818; IPR001804; IPR004434; IPR024084; "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma) (Fragment)" IDH3G Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR31745_c0_g1_i2 Q68XA5 IDH_RICTY 2.00E-56 GO:0051287; GO:0006097; GO:0004450; GO:0000287; GO:0006099 NAD binding; glyoxylate cycle; isocitrate dehydrogenase (NADP+) activity; magnesium ion binding; tricarboxylic acid cycle IPR019818; IPR001804; IPR014273; IPR024084; Isocitrate dehydrogenase [NADP] (IDH) (EC 1.1.1.42) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) icd RT0256 Rickettsia typhi (strain ATCC VR-144 / Wilmington) TR31745_c0_g1_i3 Q58991 AKSF_METJA 2.00E-44 GO:0003862; GO:0051287; GO:0019298; GO:0047046; GO:0009098; GO:0000287 3-isopropylmalate dehydrogenase activity; NAD binding; coenzyme B biosynthetic process; homoisocitrate dehydrogenase activity; leucine biosynthetic process; magnesium ion binding IPR019818; IPR001804; IPR024084; IPR011828; Organic acid metabolism; 2-oxosuberate biosynthesis. Homoisocitrate dehydrogenase (HICDH) (EC 1.1.1.87) (Isohomocitrate dehydrogenase) (IHDH) (NAD-dependent threo-isohomocitrate dehydrogenase) aksF icd MJ1596 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR31745_c0_g1_i5 Q945K7 IDH5_ARATH 1.00E-93 GO:0005524; GO:0051287; GO:0009507; GO:0004449; GO:0006102; GO:0000287; GO:0005739; GO:0006099; GO:0008270 ATP binding; NAD binding; chloroplast; isocitrate dehydrogenase (NAD+) activity; isocitrate metabolic process; magnesium ion binding; mitochondrion; tricarboxylic acid cycle; zinc ion binding IPR019818; IPR001804; IPR004434; IPR024084; "Isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial (EC 1.1.1.41) (IDH-V) (Isocitric dehydrogenase 5) (NAD(+)-specific ICDH 5)" IDH5 At5g03290 F12E4_20 MOK16.20 Arabidopsis thaliana (Mouse-ear cress) TR31745_c0_g1_i6 P41564 IDH3G_MACFA 4.00E-141 GO:0005524; GO:0051287; GO:0004449; GO:0006102; GO:0000287; GO:0005739; GO:0006099 ATP binding; NAD binding; isocitrate dehydrogenase (NAD+) activity; isocitrate metabolic process; magnesium ion binding; mitochondrion; tricarboxylic acid cycle IPR019818; IPR001804; IPR004434; IPR024084; "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma) (Fragment)" IDH3G Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR31746_c0_g1_i1 Q63486 RRAGA_RAT 0 GO:0005525; GO:0005794; GO:0006915; GO:0008219; GO:0034613; GO:0071230; GO:0005764; GO:0019048; GO:0005634; GO:0051219; GO:0045919; GO:0046982; GO:0042803 GTP binding; Golgi apparatus; apoptotic process; cell death; cellular protein localization; cellular response to amino acid stimulus; lysosome; modulation by virus of host morphology or physiology; nucleus; phosphoprotein binding; positive regulation of cytolysis; protein heterodimerization activity; protein homodimerization activity IPR006762; IPR027417; Ras-related GTP-binding protein A (Rag A) (RagA) Rraga Rattus norvegicus (Rat) TR31747_c4_g2_i1 Q99715 COCA1_HUMAN 2.00E-19 GO:0007155; GO:0030574; GO:0030199; GO:0005595; GO:0005788; GO:0022617; GO:0030020; GO:0005615; GO:0070062; GO:0001501 cell adhesion; collagen catabolic process; collagen fibril organization; collagen type XII; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular matrix structural constituent conferring tensile strength; extracellular space; extracellular vesicular exosome; skeletal system development IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) TR31747_c4_g2_i2 Q24372 LACH_DROME 6.00E-10 GO:0031225; GO:0061343; GO:0007156; GO:0035160; GO:0016331; GO:0005886; GO:0042803; GO:0035151; GO:0005918; GO:0019991 Q9VGH2 "anchored to membrane; cell adhesion involved in heart morphogenesis; homophilic cell adhesion; maintenance of epithelial integrity, open tracheal system; morphogenesis of embryonic epithelium; plasma membrane; protein homodimerization activity; regulation of tube size, open tracheal system; septate junction; septate junction assembly" IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Lachesin Lac CG12369 Drosophila melanogaster (Fruit fly) TR31747_c4_g2_i3 P28685 CNTN2_CHICK 6.00E-06 GO:0031225; GO:0007158; GO:0005886 anchored to membrane; neuron cell-cell adhesion; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Contactin-2 (Axonin-1) CNTN2 Gallus gallus (Chicken) TR31747_c4_g3_i2 Q60847 COCA1_MOUSE 2.00E-18 GO:0007155; GO:0005581; GO:0005615; GO:0070062 cell adhesion; collagen; extracellular space; extracellular vesicular exosome IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain Col12a1 Mus musculus (Mouse) TR31747_c4_g3_i3 Q80X19 COEA1_MOUSE 6.00E-19 GO:0007155; GO:0005581; GO:0030199; GO:0048873; GO:0005614; GO:0061050; GO:0003229 cell adhesion; collagen; collagen fibril organization; homeostasis of number of cells within a tissue; interstitial matrix; regulation of cell growth involved in cardiac muscle cell development; ventricular cardiac muscle tissue development IPR008160; IPR008985; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XIV) chain Col14a1 Mus musculus (Mouse) TR31747_c4_g3_i4 A2AX52 CO6A4_MOUSE 1.00E-16 GO:0007155; GO:0005581; GO:0005576; GO:0043234; GO:0070208 cell adhesion; collagen; extracellular region; protein complex; protein heterotrimerization IPR008160; IPR002035; Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) TR31747_c4_g5_i3 P13944 COCA1_CHICK 1.00E-08 GO:0007155; GO:0005581 cell adhesion; collagen IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain (Fibrochimerin) COL12A1 Gallus gallus (Chicken) TR31749_c6_g1_i1 Q8N4B1 SESQ1_HUMAN 9.00E-32 GO:0005794; GO:0030136; GO:0005769; GO:0007032; GO:0005543; GO:0001881; GO:0055037; GO:0042147; GO:0005802 "Golgi apparatus; clathrin-coated vesicle; early endosome; endosome organization; phospholipid binding; receptor recycling; recycling endosome; retrograde transport, endosome to Golgi; trans-Golgi network" IPR011993; IPR001849; Sesquipedalian-1 (Ses1) (27 kDa inositol polyphosphate phosphatase-interacting protein A) (IPIP27A) FAM109A Homo sapiens (Human) TR3175_c0_g1_i1 Q460N3 PAR15_HUMAN 3.00E-24 GO:0003950; GO:0005634; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) TR31750_c0_g1_i1 Q5ZJ74 ISCA1_CHICK 8.00E-60 GO:0016226; GO:0051536; GO:0046872; GO:0005739; GO:0005198 iron-sulfur cluster assembly; iron-sulfur cluster binding; metal ion binding; mitochondrion; structural molecule activity IPR000361; IPR016092; IPR017870; "Iron-sulfur cluster assembly 1 homolog, mitochondrial (HESB-like domain-containing protein 2) (Iron-sulfur assembly protein IscA)" ISCA1 HBLD2 RCJMB04_20e4 Gallus gallus (Chicken) TR31751_c0_g1_i1 P13608 PGCA_BOVIN 1.00E-18 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 Q9UNA0; P49747 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Bos taurus (Bovine) TR31751_c0_g1_i2 Q9UBG0 MRC2_HUMAN 2.00E-19 GO:0030246; GO:0006897; GO:0016021 carbohydrate binding; endocytosis; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; C-type mannose receptor 2 (C-type lectin domain family 13 member E) (Endocytic receptor 180) (Macrophage mannose receptor 2) (Urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (Urokinase receptor-associated protein) (CD antigen CD280) MRC2 CLEC13E ENDO180 KIAA0709 UPARAP Homo sapiens (Human) TR31753_c1_g1_i2 Q80TR4 SLIT1_MOUSE 6.00E-16 GO:0048846; GO:0005509; GO:0005737; GO:0033563; GO:0040023; GO:0005615; GO:0008045; GO:0050919; GO:0051964; GO:0005102; GO:0031290; GO:0022028 axon extension involved in axon guidance; calcium ion binding; cytoplasm; dorsal/ventral axon guidance; establishment of nucleus localization; extracellular space; motor neuron axon guidance; negative chemotaxis; negative regulation of synapse assembly; receptor binding; retinal ganglion cell axon guidance; tangential migration from the subventricular zone to the olfactory bulb IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 1 protein (Slit-1) Slit1 Kiaa0813 Mus musculus (Mouse) TR31753_c1_g1_i6 Q8IWK6 GP125_HUMAN 5.00E-71 GO:0004930; GO:0009897; GO:0016021; GO:0007218 G-protein coupled receptor activity; external side of plasma membrane; integral to membrane; neuropeptide signaling pathway IPR000483; IPR017981; IPR001879; IPR000832; IPR000203; IPR007110; IPR013783; IPR013098; IPR003599; IPR001611; IPR003591; Probable G-protein coupled receptor 125 GPR125 UNQ556/PRO1113 Homo sapiens (Human) TR31753_c1_g1_i7 Q96PE1 GP124_HUMAN 6.00E-63 GO:0004930; GO:0009986; GO:0007417; GO:0043542; GO:0016021; GO:1900747; GO:0007218; GO:0005886; GO:0010595; GO:0045765; GO:0050920; GO:0090210; GO:0002040 G-protein coupled receptor activity; cell surface; central nervous system development; endothelial cell migration; integral to membrane; negative regulation of vascular endothelial growth factor signaling pathway; neuropeptide signaling pathway; plasma membrane; positive regulation of endothelial cell migration; regulation of angiogenesis; regulation of chemotaxis; regulation of establishment of blood-brain barrier; sprouting angiogenesis IPR000483; IPR017981; IPR001879; IPR000832; IPR017983; IPR000203; IPR007110; IPR013783; IPR003599; IPR001611; IPR003591; G-protein coupled receptor 124 (Tumor endothelial marker 5) GPR124 KIAA1531 TEM5 Homo sapiens (Human) TR31753_c2_g1_i1 Q91ZV8 GP124_MOUSE 2.00E-39 GO:0004930; GO:0009986; GO:0007417; GO:0043542; GO:0016021; GO:1900747; GO:0007218; GO:0005886; GO:0010595; GO:0045765; GO:0050920; GO:0090210; GO:0002040 G-protein coupled receptor activity; cell surface; central nervous system development; endothelial cell migration; integral to membrane; negative regulation of vascular endothelial growth factor signaling pathway; neuropeptide signaling pathway; plasma membrane; positive regulation of endothelial cell migration; regulation of angiogenesis; regulation of chemotaxis; regulation of establishment of blood-brain barrier; sprouting angiogenesis IPR000483; IPR017981; IPR001879; IPR000832; IPR017983; IPR000203; IPR007110; IPR013783; IPR003599; IPR001611; IPR003591; G-protein coupled receptor 124 (Tumor endothelial marker 5) Gpr124 Tem5 Mus musculus (Mouse) TR31753_c2_g1_i2 Q7TT36 GP125_MOUSE 3.00E-56 GO:0004930; GO:0009897; GO:0016021; GO:0007218 G-protein coupled receptor activity; external side of plasma membrane; integral to membrane; neuropeptide signaling pathway IPR000483; IPR017981; IPR001879; IPR000832; IPR000203; IPR007110; IPR013783; IPR013098; IPR003599; IPR001611; IPR003591; Probable G-protein coupled receptor 125 Gpr125 Mus musculus (Mouse) TR31755_c0_g1_i1 Q9W138 U532_DROME 2.00E-37 GO:0008168 methyltransferase activity IPR021867; Probable methyltransferase BTM2 homolog (EC 2.1.1.-) CG3570 Drosophila melanogaster (Fruit fly) TR31755_c0_g1_i2 Q66J91 CG060_XENLA 2.00E-83 GO:0008168 methyltransferase activity IPR021867; Probable methyltransferase BTM2 homolog (EC 2.1.1.-) Xenopus laevis (African clawed frog) TR31755_c0_g1_i3 Q5ZJ87 CG060_CHICK 8.00E-87 GO:0008168 methyltransferase activity IPR021867; Probable methyltransferase BTM2 homolog (EC 2.1.1.-) RCJMB04_20b4 Gallus gallus (Chicken) TR31756_c0_g1_i1 A7RM45 LMBD1_NEMVE 2.00E-112 GO:0031419; GO:0016021; GO:0005765; GO:0006810 cobalamin binding; integral to membrane; lysosomal membrane; transport IPR006876; Probable lysosomal cobalamin transporter v1g160387 Nematostella vectensis (Starlet sea anemone) TR31756_c0_g1_i2 Q2TZ20 LMBD1_ASPOR 3.00E-34 GO:0031419; GO:0016021; GO:0005765; GO:0006810 cobalamin binding; integral to membrane; lysosomal membrane; transport IPR006876; Probable lysosomal cobalamin transporter AO090103000016 Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) TR31757_c1_g1_i1 Q9XYM0 CRK_DROME 3.00E-07 GO:0005070; GO:0007298; GO:0048013; GO:0046529; GO:0007520; GO:0046330; GO:0032319; GO:0032956 Q9VCH4 "SH3/SH2 adaptor activity; border follicle cell migration; ephrin receptor signaling pathway; imaginal disc fusion, thorax closure; myoblast fusion; positive regulation of JNK cascade; regulation of Rho GTPase activity; regulation of actin cytoskeleton organization" IPR000980; IPR011511; IPR001452; Adapter molecule Crk Crk CG1587 Drosophila melanogaster (Fruit fly) TR31757_c2_g1_i1 Q9TU19 NPHP1_CANFA 5.00E-61 GO:0005912; GO:0030154; GO:0030030; GO:0005911; GO:0035085; GO:0005856; GO:0007283; GO:0005923 adherens junction; cell differentiation; cell projection organization; cell-cell junction; cilium axoneme; cytoskeleton; spermatogenesis; tight junction IPR001452; Nephrocystin-1 (Fragment) NPHP1 NPH1 Canis familiaris (Dog) (Canis lupus familiaris) TR31758_c2_g1_i1 Q6TXF1 ARRD3_RAT 9.00E-23 GO:0005737 cytoplasm IPR011021; IPR011022; IPR014756; Arrestin domain-containing protein 3 (Liver regeneration-related protein LRRG00048) Arrdc3 Rattus norvegicus (Rat) TR31759_c0_g1_i1 Q6PE01 SNR40_MOUSE 0 GO:0008380; GO:0071013; GO:0005737; GO:0006397 RNA splicing; catalytic step 2 spliceosome; cytoplasm; mRNA processing IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; U5 small nuclear ribonucleoprotein 40 kDa protein (U5 snRNP 40 kDa protein) (WD repeat-containing protein 57) Snrnp40 Wdr57 Mus musculus (Mouse) TR31759_c0_g1_i2 P38123 SWD3_YEAST 6.00E-16 GO:0048188; GO:0006348; GO:0000781; GO:0051568; GO:0000723 P39706 "Set1C/COMPASS complex; chromatin silencing at telomere; chromosome, telomeric region; histone H3-K4 methylation; telomere maintenance" IPR015943; IPR001680; IPR019775; IPR017986; COMPASS component SWD3 (Complex proteins associated with SET1 protein SWD3) (Set1C component SWD3) SWD3 CPS30 SAF35 YBR175W YBR1237 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR31759_c0_g1_i3 Q00808 HETE1_PODAS 1.00E-49 GO:0005525 GTP binding IPR020472; IPR010730; IPR007111; IPR027417; IPR015943; IPR001680; IPR019775; IPR017986; Vegetative incompatibility protein HET-E-1 HET-E1 Podospora anserina (Pleurage anserina) TR31760_c3_g1_i1 Q96AX9 MIB2_HUMAN 7.00E-07 GO:0007219; GO:0005768; GO:0043123; GO:0004871; GO:0004842; GO:0008270 Q9UHD2 Notch signaling pathway; endosome; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1) MIB2 SKD ZZANK1 Homo sapiens (Human) TR31760_c3_g1_i2 Q13490 BIRC2_HUMAN 7.00E-15 GO:0035631; GO:0038061; GO:0035666; GO:0007166; GO:0006921; GO:0005829; GO:0045087; GO:0009898; GO:0070266; GO:0043066; GO:0005634; GO:0001890; GO:0043123; GO:0043161; GO:0000209; GO:0039535; GO:0051726; GO:0045595; GO:0042127; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0006355; GO:0034138; GO:0034142; GO:0003713; GO:0006351; GO:0004842; GO:0008270 P55210; Q9NR28; P63000; Q13546; O43353; Q9Y572; P57078; Q9NP84; Q12933 "CD40 receptor complex; NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; cell surface receptor signaling pathway; cellular component disassembly involved in execution phase of apoptosis; cytosol; innate immune response; internal side of plasma membrane; necroptosis; negative regulation of apoptotic process; nucleus; placenta development; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of RIG-I signaling pathway; regulation of cell cycle; regulation of cell differentiation; regulation of cell proliferation; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; regulation of transcription, DNA-dependent; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (IAP-2) (hIAP-2) (hIAP2) (RING finger protein 48) (TNFR2-TRAF-signaling complex protein 2) BIRC2 API1 IAP2 MIHB RNF48 Homo sapiens (Human) TR31760_c3_g2_i1 O62640 PIAP_PIG 3.00E-35 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR31760_c3_g2_i2 Q24307 IAP2_DROME 5.00E-38 GO:0050829; GO:0043066; GO:0043154; GO:0061057; GO:0006964; GO:0033160; GO:0070534; GO:0007423; GO:0008270 "defense response to Gram-negative bacterium; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; peptidoglycan recognition protein signaling pathway; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; positive regulation of protein import into nucleus, translocation; protein K63-linked ubiquitination; sensory organ development; zinc ion binding" IPR001370; IPR001841; IPR013083; Apoptosis 2 inhibitor (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) (dIAP2) Iap2 DIHA ILP CG8293 Drosophila melanogaster (Fruit fly) TR31760_c3_g2_i3 Q24306 IAP1_DROME 7.00E-20 GO:0019788; GO:0016055; GO:0048800; GO:0007298; GO:0008407; GO:0004869; GO:0005737; GO:0008354; GO:0097340; GO:1990001; GO:0043066; GO:0046673; GO:0005634; GO:0090263; GO:0031398; GO:0042787; GO:0045035; GO:0007289; GO:0004842; GO:0008270 P25843; Q86PE7; Q9XYF4; Q24475; Q24106 NEDD8 ligase activity; Wnt receptor signaling pathway; antennal morphogenesis; border follicle cell migration; chaeta morphogenesis; cysteine-type endopeptidase inhibitor activity; cytoplasm; germ cell migration; inhibition of cysteine-type endopeptidase activity; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of compound eye retinal cell programmed cell death; nucleus; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; sensory organ precursor cell division; spermatid nucleus differentiation; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; Apoptosis 1 inhibitor (EC 6.3.2.-) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (dIAP1) (Protein thread) th Iap1 CG12284 Drosophila melanogaster (Fruit fly) TR31762_c2_g1_i1 Q6IC98 GRAM4_HUMAN 1.00E-34 GO:0006915; GO:0016021; GO:0031966 apoptotic process; integral to membrane; mitochondrial membrane IPR004182; GRAM domain-containing protein 4 (Death-inducing protein) GRAMD4 DIP KIAA0767 Homo sapiens (Human) TR31762_c2_g2_i2 A2RV80 GRAM4_XENLA 3.00E-22 GO:0006915; GO:0016021; GO:0031966 apoptotic process; integral to membrane; mitochondrial membrane IPR004182; GRAM domain-containing protein 4 gramd4 Xenopus laevis (African clawed frog) TR31763_c0_g2_i1 Q8N1B4 VPS52_HUMAN 0 GO:0005794; GO:0010668; GO:0048611; GO:0010008; GO:0015031 Golgi apparatus; ectodermal cell differentiation; embryonic ectodermal digestive tract development; endosome membrane; protein transport IPR007258; Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein) VPS52 SACM2L Homo sapiens (Human) TR31763_c0_g3_i1 Q8N1B4 VPS52_HUMAN 1.00E-32 GO:0005794; GO:0010668; GO:0048611; GO:0010008; GO:0015031 Golgi apparatus; ectodermal cell differentiation; embryonic ectodermal digestive tract development; endosome membrane; protein transport IPR007258; Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein) VPS52 SACM2L Homo sapiens (Human) TR31764_c1_g1_i1 Q9S9V0 CDPKV_ARATH 3.00E-07 GO:0005524; GO:0005509; GO:0016020; GO:0004674; GO:0009751 ATP binding; calcium ion binding; membrane; protein serine/threonine kinase activity; response to salicylic acid stimulus IPR011992; IPR018247; IPR002048; IPR011009; IPR000719; IPR017441; IPR002290; Calcium-dependent protein kinase 31 (EC 2.7.11.1) CPK31 At4g04695 T19J18.7 Arabidopsis thaliana (Mouse-ear cress) TR31764_c1_g1_i2 Q9NZT1 CALL5_HUMAN 1.00E-07 GO:0005509; GO:0008544; GO:0007165 calcium ion binding; epidermis development; signal transduction IPR011992; IPR018247; IPR002048; Calmodulin-like protein 5 (Calmodulin-like skin protein) CALML5 CLSP Homo sapiens (Human) TR31766_c0_g2_i1 Q5R7X9 RAD1_PONAB 5.00E-120 GO:0008408; GO:0000077; GO:0006281; GO:0071479; GO:0008853; GO:0090305; GO:0005634 3'-5' exonuclease activity; DNA damage checkpoint; DNA repair; cellular response to ionizing radiation; exodeoxyribonuclease III activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR003011; IPR003021; Cell cycle checkpoint protein RAD1 (EC 3.1.11.2) (DNA repair exonuclease rad1 homolog) RAD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR31767_c2_g1_i1 Q8K4Q8 COL12_MOUSE 5.00E-12 GO:0030246; GO:0005581; GO:0006955; GO:0016021; GO:0030169; GO:0046872; GO:0006910; GO:0008329 "carbohydrate binding; collagen; immune response; integral to membrane; low-density lipoprotein particle binding; metal ion binding; phagocytosis, recognition; signaling pattern recognition receptor activity" IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-12 (Collectin placenta protein 1) (CL-P1) (Scavenger receptor with C-type lectin) Colec12 Clp1 Srcl Mus musculus (Mouse) TR31767_c5_g1_i1 Q8HY00 CD209_PONPY 3.00E-19 GO:0007155; GO:0006897; GO:0045087; GO:0016021; GO:0005537; GO:0046872 cell adhesion; endocytosis; innate immune response; integral to membrane; mannose binding; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; CD209 antigen (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN1) (CD antigen CD209) CD209 Pongo pygmaeus (Bornean orangutan) TR31767_c6_g1_i1 Q38HS3 KLRD1_CANFA 9.00E-06 GO:0030246; GO:0009897; GO:0016021 carbohydrate binding; external side of plasma membrane; integral to membrane IPR001304; IPR016186; IPR016187; Natural killer cells antigen CD94 (Killer cell lectin-like receptor subfamily D member 1) (CD antigen CD94) KLRD1 CD94 Canis familiaris (Dog) (Canis lupus familiaris) TR31767_c7_g1_i1 O54709 NKG2D_MOUSE 2.00E-06 GO:0032394; GO:0030246; GO:0071222; GO:0050830; GO:0009897; GO:0016021; GO:0030101; GO:0032729; GO:0045954; GO:0045429; GO:0042803; GO:0002223 MHC class Ib receptor activity; carbohydrate binding; cellular response to lipopolysaccharide; defense response to Gram-positive bacterium; external side of plasma membrane; integral to membrane; natural killer cell activation; positive regulation of interferon-gamma production; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of nitric oxide biosynthetic process; protein homodimerization activity; stimulatory C-type lectin receptor signaling pathway IPR001304; IPR016186; IPR016187; NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314) Klrk1 Nkg2d Mus musculus (Mouse) TR31767_c7_g3_i1 Q61830 MRC1_MOUSE 3.00E-30 GO:0009986; GO:0010008; GO:0016021; GO:0005537; GO:0005886; GO:0006898; GO:0004888 cell surface; endosome membrane; integral to membrane; mannose binding; plasma membrane; receptor-mediated endocytosis; transmembrane signaling receptor activity IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; Macrophage mannose receptor 1 (MMR) (CD antigen CD206) Mrc1 Mus musculus (Mouse) TR31767_c7_g5_i1 P13608 PGCA_BOVIN 3.00E-07 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 Q9UNA0; P49747 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Bos taurus (Bovine) TR31767_c8_g1_i1 O43854 EDIL3_HUMAN 9.00E-25 GO:0005509; GO:0007155; GO:0070062; GO:0005178; GO:0007275; GO:0010811 calcium ion binding; cell adhesion; extracellular vesicular exosome; integrin binding; multicellular organismal development; positive regulation of cell-substrate adhesion IPR000421; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR008979; EGF-like repeat and discoidin I-like domain-containing protein 3 (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1) EDIL3 DEL1 Homo sapiens (Human) TR31768_c4_g2_i2 Q9ULL5 PRR12_HUMAN 4.00E-18 GO:0003677 DNA binding IPR017956; IPR025451; Proline-rich protein 12 PRR12 KIAA1205 Homo sapiens (Human) TR31769_c0_g2_i1 Q8QGW7 LITAF_CHICK 1.00E-10 GO:0005125; GO:0005737; GO:0006355; GO:0006351 "cytokine activity; cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) TR31771_c1_g1_i2 Q9FKS8 LHT1_ARATH 3.00E-21 GO:0043090; GO:0015171; GO:0016021; GO:0005886; GO:0080167; GO:0015293 amino acid import; amino acid transmembrane transporter activity; integral to membrane; plasma membrane; response to karrikin; symporter activity IPR013057; Lysine histidine transporter 1 LHT1 At5g40780 K1B16.3 Arabidopsis thaliana (Mouse-ear cress) TR31772_c0_g1_i1 Q5E9D6 HDHD3_BOVIN 6.00E-55 GO:0016787; GO:0005739 hydrolase activity; mitochondrion IPR023214; IPR006439; IPR011949; Haloacid dehalogenase-like hydrolase domain-containing protein 3 HDHD3 Bos taurus (Bovine) TR31773_c0_g3_i1 Q75J93 CPAS1_DICDI 5.00E-117 GO:0030127; GO:0006888; GO:0005525; GO:0003924; GO:0006886; GO:0007264; GO:0008270 COPII vesicle coat; ER to Golgi vesicle-mediated transport; GTP binding; GTPase activity; intracellular protein transport; small GTPase mediated signal transduction; zinc ion binding IPR027417; IPR005225; IPR001806; IPR020849; IPR002035; IPR006895; Circularly permutated Ras protein 1 (DdiCPRas1) cpras1 DDB_G0277381 Dictyostelium discoideum (Slime mold) TR31776_c0_g1_i1 P18745 ZO22_XENLA 2.00E-29 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Oocyte zinc finger protein XlCOF22 Xenopus laevis (African clawed frog) TR31776_c0_g1_i2 P10076 ZFP26_MOUSE 2.00E-37 GO:0003677; GO:0046872; GO:0005634; GO:0006355 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 26 (Zfp-26) (Protein mKR3) Zfp26 Kiaa4196 Mkr3 Zfp-26 Mus musculus (Mouse) TR31777_c7_g1_i1 Q5ND28 SREC_MOUSE 4.00E-08 GO:0007155; GO:0016358; GO:0016021; GO:0030169; GO:0016322; GO:0005886; GO:0048680; GO:0005044 cell adhesion; dendrite development; integral to membrane; low-density lipoprotein particle binding; neuron remodeling; plasma membrane; positive regulation of axon regeneration; scavenger receptor activity IPR000742; IPR013032; IPR002049; IPR009030; Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) TR31779_c2_g1_i3 Q96MT7 WDR52_HUMAN 2.00E-06 IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 52 WDR52 Homo sapiens (Human) TR31782_c0_g2_i1 Q6GL75 DCC1_XENTR 6.00E-78 GO:0003677; GO:0006260; GO:0000785; GO:0034088; GO:0005634; GO:0006275 DNA binding; DNA replication; chromatin; maintenance of mitotic sister chromatid cohesion; nucleus; regulation of DNA replication IPR019128; Sister chromatid cohesion protein DCC1 dscc1 dcc1 TNeu038i11.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31783_c0_g1_i5 Q9W6G7 DPOG2_XENLA 8.00E-42 GO:0003677; GO:0006281; GO:0006260; GO:0003887; GO:0005739 DNA binding; DNA repair; DNA replication; DNA-directed DNA polymerase activity; mitochondrion IPR004154; IPR027031; IPR027030; "DNA polymerase subunit gamma-2, mitochondrial (EC 2.7.7.7) (Mitochondrial DNA polymerase accessory subunit) (MtPolB) (PolG-beta)" polg2 mtpolb Xenopus laevis (African clawed frog) TR31784_c0_g2_i1 P80009 PLMN_CANFA 1.00E-48 GO:0006915; GO:0007596; GO:0022617; GO:0005615; GO:0031232; GO:0042730; GO:0060716; GO:0071674; GO:0046716; GO:0045445; GO:0010812; GO:0051918; GO:0051919; GO:0006508; GO:0004252; GO:0042246; GO:0048771; GO:0060707 apoptotic process; blood coagulation; extracellular matrix disassembly; extracellular space; extrinsic to external side of plasma membrane; fibrinolysis; labyrinthine layer blood vessel development; mononuclear cell migration; muscle cell cellular homeostasis; myoblast differentiation; negative regulation of cell-substrate adhesion; negative regulation of fibrinolysis; positive regulation of fibrinolysis; proteolysis; serine-type endopeptidase activity; tissue regeneration; tissue remodeling; trophoblast giant cell differentiation IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR009003; Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Plasmin light chain B] (Fragment) PLG Canis familiaris (Dog) (Canis lupus familiaris) TR31785_c0_g1_i1 P77735 YAJO_ECOLI 6.00E-42 GO:0016491; GO:0006772 oxidoreductase activity; thiamine metabolic process IPR001395; IPR020471; IPR023210; Uncharacterized oxidoreductase YajO (EC 1.-.-.-) yajO b0419 JW0409 Escherichia coli (strain K12) TR31786_c3_g1_i1 O42603 CRFR2_XENLA 3.00E-71 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR017981; IPR003053; IPR003051; IPR001879; IPR000832; IPR017983; Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2) crhr2 crf2 Xenopus laevis (African clawed frog) TR31786_c3_g1_i2 Q16983 DIHR_ACHDO 6.00E-61 GO:0004930; GO:0008036; GO:0009755; GO:0016021; GO:0005886 G-protein coupled receptor activity; diuretic hormone receptor activity; hormone-mediated signaling pathway; integral to membrane; plasma membrane IPR017981; IPR002001; IPR001879; IPR000832; IPR017983; Diuretic hormone receptor (DH-R) Acheta domesticus (House cricket) TR31788_c0_g1_i1 Q9H9Y6 RPA2_HUMAN 0 GO:0003677; GO:0005736; GO:0003899; GO:0005737; GO:0009790; GO:0007566; GO:0046872; GO:0017126; GO:0005654; GO:0009303; GO:0032549; GO:0006363; GO:0006362; GO:0006361 O95602 DNA binding; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase activity; cytoplasm; embryo development; embryo implantation; metal ion binding; nucleologenesis; nucleoplasm; rRNA transcription; ribonucleoside binding; termination of RNA polymerase I transcription; transcription elongation from RNA polymerase I promoter; transcription initiation from RNA polymerase I promoter IPR015712; IPR007120; IPR007121; IPR007644; IPR009674; IPR007642; IPR007645; IPR007647; IPR007641; IPR014724; DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135) POLR1B Homo sapiens (Human) TR31788_c0_g2_i1 P70700 RPA2_MOUSE 0 GO:0003677; GO:0005736; GO:0003899; GO:0009790; GO:0007566; GO:0046872; GO:0017126; GO:0005654; GO:0009303; GO:0032549 DNA binding; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase activity; embryo development; embryo implantation; metal ion binding; nucleologenesis; nucleoplasm; rRNA transcription; ribonucleoside binding IPR015712; IPR007120; IPR007121; IPR007644; IPR009674; IPR007642; IPR007645; IPR007641; IPR014724; DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135) Polr1b Rpa2 Rpo1-2 Mus musculus (Mouse) TR31788_c0_g2_i3 O27123 RPOB2_METTH 1.00E-14 GO:0003677; GO:0003899; GO:0032549; GO:0006351 "DNA binding; DNA-directed RNA polymerase activity; ribonucleoside binding; transcription, DNA-dependent" IPR015712; IPR007644; IPR007642; IPR007645; DNA-directed RNA polymerase subunit B'' (EC 2.7.7.6) rpoB2 MTH_1049 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) TR31788_c0_g2_i5 Q9H9Y6 RPA2_HUMAN 0 GO:0003677; GO:0005736; GO:0003899; GO:0005737; GO:0009790; GO:0007566; GO:0046872; GO:0017126; GO:0005654; GO:0009303; GO:0032549; GO:0006363; GO:0006362; GO:0006361 O95602 DNA binding; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase activity; cytoplasm; embryo development; embryo implantation; metal ion binding; nucleologenesis; nucleoplasm; rRNA transcription; ribonucleoside binding; termination of RNA polymerase I transcription; transcription elongation from RNA polymerase I promoter; transcription initiation from RNA polymerase I promoter IPR015712; IPR007120; IPR007121; IPR007644; IPR009674; IPR007642; IPR007645; IPR007647; IPR007641; IPR014724; DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135) POLR1B Homo sapiens (Human) TR31790_c1_g1_i1 P70097 C560_CRIGR 2.00E-35 GO:0009055; GO:0020037; GO:0016021; GO:0046872; GO:0005749; GO:0000104; GO:0006099 electron carrier activity; heme binding; integral to membrane; metal ion binding; mitochondrial respiratory chain complex II; succinate dehydrogenase activity; tricarboxylic acid cycle IPR018495; IPR014314; IPR014361; IPR000701; Carbohydrate metabolism; tricarboxylic acid cycle. "Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Integral membrane protein CII-3) (QPs-1) (QPs1)" SDHC Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR31791_c5_g1_i1 P86854 PLCL_MYTGA 4.00E-15 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR31792_c1_g1_i1 Q9Y575 ASB3_HUMAN 2.00E-09 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 3 (ASB-3) ASB3 Homo sapiens (Human) TR31792_c2_g1_i1 Q8Q0U0 Y045_METMA 5.00E-09 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR31792_c3_g1_i1 Q9BZL4 PP12C_HUMAN 7.00E-10 GO:0005737 P84022 cytoplasm IPR002110; IPR020683; IPR017401; Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) PPP1R12C LENG3 MBS85 Homo sapiens (Human) TR31792_c4_g1_i1 Q9J507 V228_FOWPN 3.00E-06 IPR002110; IPR020683; IPR018272; Putative ankyrin repeat protein FPV228 FPV228 Fowlpox virus (strain NVSL) (FPV) TR31794_c0_g1_i1 Q6FMR7 ACN9_CANGA 9.00E-12 GO:0006094; GO:0005758 gluconeogenesis; mitochondrial intermembrane space IPR008381; IPR008011; "Acetate non-utilizing protein 9, mitochondrial" ACN9 CAGL0K05775g Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) TR31794_c0_g1_i2 Q5XIY4 ACN9_DANRE 3.00E-25 GO:0005739 mitochondrion IPR008381; "Protein ACN9 homolog, mitochondrial" acn9 zgc:92826 Danio rerio (Zebrafish) (Brachydanio rerio) TR31795_c0_g1_i1 Q92665 RT31_HUMAN 1.00E-35 GO:0005763; GO:0005739; GO:0003735 P40763 mitochondrial small ribosomal subunit; mitochondrion; structural constituent of ribosome IPR026299; "28S ribosomal protein S31, mitochondrial (MRP-S31) (S31mt) (Imogen 38)" MRPS31 IMOGN38 Homo sapiens (Human) TR31796_c0_g1_i1 Q96S52 PIGS_HUMAN 8.00E-52 GO:0006501; GO:0003923; GO:0042765; GO:0016255 C-terminal protein lipidation; GPI-anchor transamidase activity; GPI-anchor transamidase complex; attachment of GPI anchor to protein IPR019540; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. GPI transamidase component PIG-S (Phosphatidylinositol-glycan biosynthesis class S protein) PIGS UNQ1873/PRO4316 Homo sapiens (Human) TR31796_c0_g1_i2 Q10351 PIGS_SCHPO 5.00E-18 GO:0042765; GO:0016255; GO:0005783 GPI-anchor transamidase complex; attachment of GPI anchor to protein; endoplasmic reticulum IPR019540; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. GPI transamidase component PIG-S homolog gpi17 SPAC1F12.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR31798_c1_g1_i1 Q80TT2 BAIP3_MOUSE 8.00E-78 IPR000008; IPR014770; IPR014772; IPR019558; BAI1-associated protein 3 (BAP3) Baiap3 Gm937 Kiaa0734 Mus musculus (Mouse) TR31800_c0_g1_i1 Q5RCI5 MET12_PONAB 3.00E-21 GO:0008168; GO:0005739 methyltransferase activity; mitochondrion IPR025714; "Methyltransferase-like protein 12, mitochondrial (EC 2.1.1.-)" METTL12 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR31802_c2_g1_i1 Q7T320 GORAB_DANRE 2.00E-30 GO:0005794 Golgi apparatus IPR007033; RAB6-interacting golgin (N-terminal kinase-like-binding protein 1) (NTKL-BP1) (NTKL-binding protein 1) (SCY1-like 1-binding protein 1) (SCYL1-BP1) (SCYL1-binding protein 1) gorab scyl1bp1 zgc:64162 Danio rerio (Zebrafish) (Brachydanio rerio) TR31802_c2_g1_i3 Q7T320 GORAB_DANRE 3.00E-30 GO:0005794 Golgi apparatus IPR007033; RAB6-interacting golgin (N-terminal kinase-like-binding protein 1) (NTKL-BP1) (NTKL-binding protein 1) (SCY1-like 1-binding protein 1) (SCYL1-BP1) (SCYL1-binding protein 1) gorab scyl1bp1 zgc:64162 Danio rerio (Zebrafish) (Brachydanio rerio) TR31803_c1_g1_i1 P04323 POL3_DROME 7.00E-57 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR31803_c1_g2_i1 P92523 M860_ARATH 1.00E-17 GO:0005739 mitochondrion Uncharacterized mitochondrial protein AtMg00860 (ORF158) AtMg00860 Arabidopsis thaliana (Mouse-ear cress) TR31803_c2_g1_i1 Q7TD08 POL_CYLCV 2.00E-17 GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0046872; GO:0090305; GO:0006508 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR000588; IPR021109; IPR000477; Enzymatic polyprotein [Includes: Aspartic protease (EC 3.4.23.-); Endonuclease; Reverse transcriptase (EC 2.7.7.49)] ORF V Cestrum yellow leaf curling virus (CmYLCV) TR31803_c2_g2_i1 Q09575 YRD6_CAEEL 1.00E-13 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR31803_c2_g3_i1 P20825 POL2_DROME 2.00E-25 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR31803_c3_g1_i1 Q6NU91 NOC4B_XENLA 4.00E-129 GO:0016021; GO:0031965; GO:0005730; GO:0042254 integral to membrane; nuclear membrane; nucleolus; ribosome biogenesis IPR016024; IPR005612; IPR027193; Nucleolar complex protein 4 homolog B (NOC4 protein homolog B) (NOC4-like protein B) (Nucleolar complex-associated protein 4-like protein B) noc4l-b Xenopus laevis (African clawed frog) TR31804_c0_g1_i1 Q5ZJU3 ASNS_CHICK 0 GO:0005524; GO:0070981; GO:0004066; GO:0006541 ATP binding; L-asparagine biosynthetic process; asparagine synthase (glutamine-hydrolyzing) activity; glutamine metabolic process IPR006426; IPR001962; IPR017932; IPR000583; IPR014729; Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1. Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) (Glutamine-dependent asparagine synthetase) ASNS RCJMB04_15l3 Gallus gallus (Chicken) TR31805_c0_g1_i1 O22315 SRSF1_ARATH 4.00E-09 GO:0003723; GO:0008380; GO:0035061; GO:0006397; GO:0016607; GO:0000166 Q9LY75 RNA binding; RNA splicing; interchromatin granule; mRNA processing; nuclear speck; nucleotide binding IPR012677; IPR000504; Pre-mRNA-splicing factor SF2 (SR1 protein) SF2 At1g02840 F22D16.16 F22D16_30 Arabidopsis thaliana (Mouse-ear cress) TR31805_c0_g1_i10 Q29RT0 RBMX_BOVIN 3.00E-07 GO:0008380; GO:0071013; GO:0071347; GO:0003682; GO:0001047; GO:0070062; GO:0003729; GO:0006397; GO:0006509; GO:0048025; GO:0005719; GO:0000166; GO:0048026; GO:0045944; GO:0051260; GO:0000381; GO:0044530; GO:0006366 "RNA splicing; catalytic step 2 spliceosome; cellular response to interleukin-1; chromatin binding; core promoter binding; extracellular vesicular exosome; mRNA binding; mRNA processing; membrane protein ectodomain proteolysis; negative regulation of mRNA splicing, via spliceosome; nuclear euchromatin; nucleotide binding; positive regulation of mRNA splicing, via spliceosome; positive regulation of transcription from RNA polymerase II promoter; protein homooligomerization; regulation of alternative mRNA splicing, via spliceosome; supraspliceosomal complex; transcription from RNA polymerase II promoter" IPR012677; IPR012604; IPR000504; "RNA-binding motif protein, X chromosome (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]" RBMX HNRPG Bos taurus (Bovine) TR31805_c0_g1_i2 Q4WJT7 MRD1_ASPFU 4.00E-10 GO:0003723; GO:0000166; GO:0005634; GO:0006364; GO:0030529 RNA binding; nucleotide binding; nucleus; rRNA processing; ribonucleoprotein complex IPR012677; IPR000504; Multiple RNA-binding domain-containing protein 1 mrd1 AFUA_1G04840 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) TR31805_c0_g1_i7 Q8WXF0 SRS12_HUMAN 3.00E-40 GO:0003723; GO:0050733; GO:0000244; GO:0016482; GO:0000395; GO:0048025; GO:0005654; GO:0000166; GO:0000381; GO:0051082 "RNA binding; RS domain binding; assembly of spliceosomal tri-snRNP; cytoplasmic transport; mRNA 5'-splice site recognition; negative regulation of mRNA splicing, via spliceosome; nucleoplasm; nucleotide binding; regulation of alternative mRNA splicing, via spliceosome; unfolded protein binding" IPR012677; IPR000504; "Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)" SRSF12 SFRS13B SFRS19 SRRP35 Homo sapiens (Human) TR31807_c0_g1_i1 O70445 BARD1_MOUSE 1.00E-13 GO:0070531; GO:0031436; GO:0006281; GO:0003723; GO:0005737; GO:0016874; GO:0043066; GO:0046826; GO:0043065; GO:0085020; GO:0046982; GO:0042803; GO:0042325; GO:0008270 BRCA1-A complex; BRCA1-BARD1 complex; DNA repair; RNA binding; cytoplasm; ligase activity; negative regulation of apoptotic process; negative regulation of protein export from nucleus; positive regulation of apoptotic process; protein K6-linked ubiquitination; protein heterodimerization activity; protein homodimerization activity; regulation of phosphorylation; zinc ion binding IPR002110; IPR020683; IPR001357; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. BRCA1-associated RING domain protein 1 (BARD-1) (EC 6.3.2.-) Bard1 Mus musculus (Mouse) TR31807_c0_g1_i3 Q6DGX3 ANR54_DANRE 8.00E-14 GO:0005737; GO:0030496; GO:0005634 cytoplasm; midbody; nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 54 ankrd54 zgc:110569 zgc:92735 Danio rerio (Zebrafish) (Brachydanio rerio) TR31811_c3_g1_i1 Q67XX3 FB252_ARATH 3.00E-06 GO:0000987; GO:0043985; GO:0005634; GO:0010030 core promoter proximal region sequence-specific DNA binding; histone H4-R3 methylation; nucleus; positive regulation of seed germination IPR001810; IPR003347; F-box protein At5g06550 At5g06550 F15M7.8 Arabidopsis thaliana (Mouse-ear cress) TR31811_c3_g2_i1 Q5RHU7 MDM1_DANRE 5.00E-08 GO:0005634 nucleus Nuclear protein MDM1 mdm1 si:ch211-266a5.6 Danio rerio (Zebrafish) (Brachydanio rerio) TR31811_c3_g2_i3 Q5PQN4 MDM1_RAT 1.00E-14 GO:0005634 nucleus Nuclear protein MDM1 Mdm1 Rattus norvegicus (Rat) TR31815_c3_g2_i1 Q8BFR1 ZCCHL_MOUSE 3.00E-06 GO:0046872 metal ion binding IPR026693; IPR000571; Zinc finger CCCH-type antiviral protein 1-like Zc3hav1l Mus musculus (Mouse) TR31815_c5_g1_i1 O43390 HNRPR_HUMAN 3.00E-10 GO:0003723; GO:0071013; GO:0005737; GO:0000398; GO:0005654; GO:0000166 P16333 "RNA binding; catalytic step 2 spliceosome; cytoplasm; mRNA splicing, via spliceosome; nucleoplasm; nucleotide binding" IPR006535; IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein R (hnRNP R) HNRNPR HNRPR Homo sapiens (Human) TR31817_c0_g1_i1 Q2KIU2 PMVK_BOVIN 2.00E-62 GO:0005524; GO:0006695; GO:0019287; GO:0005777; GO:0004631 "ATP binding; cholesterol biosynthetic process; isopentenyl diphosphate biosynthetic process, mevalonate pathway; peroxisome; phosphomevalonate kinase activity" IPR027417; IPR005919; Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3. Phosphomevalonate kinase (PMKase) (EC 2.7.4.2) PMVK Bos taurus (Bovine) TR31819_c2_g1_i2 P25867 UBCD1_DROME 5.00E-94 GO:0005524; GO:0051276; GO:0001751; GO:0008054; GO:0048132; GO:0030718; GO:0007140; GO:0005875; GO:0007067; GO:0016322; GO:0045676; GO:0031647; GO:0007286; GO:0004842 ATP binding; chromosome organization; compound eye photoreceptor cell differentiation; cyclin catabolic process; female germ-line stem cell division; germ-line stem cell maintenance; male meiosis; microtubule associated complex; mitosis; neuron remodeling; regulation of R7 cell differentiation; regulation of protein stability; spermatid development; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2-17 kDa (EC 6.3.2.19) (Protein effete) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) eff UbcD1 CG7425 Drosophila melanogaster (Fruit fly) TR31820_c1_g1_i1 P34147 RACA_DICDI 2.00E-141 GO:0005525; GO:0005622; GO:0007264 GTP binding; intracellular; small GTPase mediated signal transduction IPR000210; IPR011333; IPR013069; IPR027417; IPR005225; IPR001806; IPR003578; Rho-related protein racA racA DDB_G0286555 Dictyostelium discoideum (Slime mold) TR31820_c1_g1_i2 O94955 RHBT3_HUMAN 8.00E-46 GO:0005524; GO:0016887; GO:0005525; GO:0005794; GO:0042147; GO:0007264 P24408 "ATP binding; ATPase activity; GTP binding; Golgi apparatus; retrograde transport, endosome to Golgi; small GTPase mediated signal transduction" IPR000210; IPR011333; IPR013069; IPR027417; IPR001806; Rho-related BTB domain-containing protein 3 (EC 3.6.1.-) RHOBTB3 KIAA0878 Homo sapiens (Human) TR31821_c3_g1_i1 P45219 FTSHL_HAEIN 2.00E-11 GO:0005524; GO:0006200; GO:0016887; GO:0016020; GO:0004222; GO:0030163; GO:0006508; GO:0008270 ATP binding; ATP catabolic process; ATPase activity; membrane; metalloendopeptidase activity; protein catabolic process; proteolysis; zinc ion binding IPR003959; IPR003960; IPR005936; IPR027417; IPR000642; ATP-dependent zinc metalloprotease FtsH homolog HI_1465 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) TR31821_c6_g1_i1 Q2EEX7 FTSHL_HELSJ 2.00E-13 GO:0005524; GO:0016021; GO:0017111; GO:0042170 ATP binding; integral to membrane; nucleoside-triphosphatase activity; plastid membrane IPR003593; IPR003959; IPR003960; IPR027417; ATP-dependent zinc metalloprotease FtsH homolog ftsH Helicosporidium sp. subsp. Simulium jonesii (Green alga) TR31821_c6_g1_i2 Q6P4W8 PCH2_XENTR 3.00E-16 GO:0005524; GO:0030154; GO:0006302; GO:0017111; GO:0048477; GO:0007131; GO:0007283; GO:0007130 ATP binding; cell differentiation; double-strand break repair; nucleoside-triphosphatase activity; oogenesis; reciprocal meiotic recombination; spermatogenesis; synaptonemal complex assembly IPR003593; IPR003959; IPR003960; IPR001270; IPR027417; Pachytene checkpoint protein 2 homolog (Thyroid hormone receptor interactor 13 homolog) (Thyroid receptor-interacting protein 13 homolog) (TR-interacting protein 13 homolog) (TRIP-13 homolog) trip13 pch2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31821_c6_g1_i3 Q3UMC0 SPAT5_MOUSE 2.00E-98 GO:0005524; GO:0030154; GO:0005739; GO:0007275; GO:0017111; GO:0007283 ATP binding; cell differentiation; mitochondrion; multicellular organismal development; nucleoside-triphosphatase activity; spermatogenesis IPR003593; IPR009010; IPR003959; IPR003960; IPR003338; IPR027417; Spermatogenesis-associated protein 5 (Spermatogenesis-associated factor protein) Spata5 Spaf Mus musculus (Mouse) TR31824_c0_g1_i1 O42978 LSM5_SCHPO 8.00E-23 GO:0003723; GO:0046540; GO:0005688; GO:0006402; GO:0045292; GO:0005730; GO:0006364; GO:0005732; GO:0005681; GO:0008033 "RNA binding; U4/U6 x U5 tri-snRNP complex; U6 snRNP; mRNA catabolic process; mRNA cis splicing, via spliceosome; nucleolus; rRNA processing; small nucleolar ribonucleoprotein complex; spliceosomal complex; tRNA processing" IPR010920; IPR001163; IPR006649; U6 snRNA-associated Sm-like protein LSm5 lsm5 SPBC20F10.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR31824_c0_g1_i3 Q5R628 LSM5_PONAB 3.00E-50 GO:0003723; GO:0008380; GO:0006397; GO:0005681 RNA binding; RNA splicing; mRNA processing; spliceosomal complex IPR010920; IPR001163; IPR006649; U6 snRNA-associated Sm-like protein LSm5 LSM5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR31825_c0_g1_i1 Q9Y6N1 COX11_HUMAN 2.00E-79 GO:0005507; GO:0004129; GO:0009055; GO:0016021; GO:0005743; GO:0005739; GO:0008535; GO:0007585 copper ion binding; cytochrome-c oxidase activity; electron carrier activity; integral to membrane; mitochondrial inner membrane; mitochondrion; respiratory chain complex IV assembly; respiratory gaseous exchange IPR023471; IPR007533; "Cytochrome c oxidase assembly protein COX11, mitochondrial" COX11 Homo sapiens (Human) TR31826_c0_g1_i1 Q641F8 TYW3_XENLA 1.00E-65 GO:0008168; GO:0008033 methyltransferase activity; tRNA processing IPR003827; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. tRNA wybutosine-synthesizing protein 3 homolog (EC 2.1.1.282) (tRNA-yW-synthesizing protein 3) tyw3 Xenopus laevis (African clawed frog) TR31827_c1_g1_i1 Q9M0X9 4CLL7_ARATH 1.00E-29 GO:0005524; GO:0004321; GO:0009695; GO:0016874; GO:0031408; GO:0005777 ATP binding; fatty-acyl-CoA synthase activity; jasmonic acid biosynthetic process; ligase activity; oxylipin biosynthetic process; peroxisome IPR025110; IPR020845; IPR000873; 4-coumarate--CoA ligase-like 7 (EC 6.2.1.-) (4-coumarate--CoA ligase isoform 6) (At4CL6) 4CLL7 At4g05160 C17L7.80 Arabidopsis thaliana (Mouse-ear cress) TR31827_c1_g1_i2 Q9C9G2 AEE22_ARATH 2.00E-16 GO:0006631; GO:0016874 fatty acid metabolic process; ligase activity IPR025110; IPR000873; Probable acyl-activating enzyme 22 (EC 6.2.1.-) AEE22 At1g68270 T22E19.10 Arabidopsis thaliana (Mouse-ear cress) TR31828_c1_g1_i1 Q29J90 MOODY_DROPS 4.00E-12 GO:0004930; GO:0008366; GO:0048148; GO:0016021; GO:0005886 G-protein coupled receptor activity; axon ensheathment; behavioral response to cocaine; integral to membrane; plasma membrane IPR000276; IPR017452; G-protein coupled receptor moody moody GA18107 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR31829_c1_g2_i1 Q4R8R3 CC112_MACFA 7.00E-53 Coiled-coil domain-containing protein 112 CCDC112 QtsA-11732 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR31831_c2_g1_i4 P41437 IAP3_NPVOP 7.00E-22 GO:0006915; GO:0016874; GO:0039648; GO:0008270 apoptotic process; ligase activity; modulation by virus of host protein ubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; E3 ubiquitin-protein ligase IAP-3 (EC 6.3.2.-) (IAP-3) IAP3 IAP ORF35 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) TR31833_c4_g1_i1 Q04779 RCO1_YEAST 1.00E-06 GO:0032221; GO:0016575; GO:0060195; GO:0030174; GO:0006368; GO:0008270 Rpd3S complex; histone deacetylation; negative regulation of antisense RNA transcription; regulation of DNA-dependent DNA replication initiation; transcription elongation from RNA polymerase II promoter; zinc ion binding IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Transcriptional regulatory protein RCO1 RCO1 YMR075W YM9916.14 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR31833_c4_g1_i2 Q9UIG0 BAZ1B_HUMAN 8.00E-37 GO:0005524; GO:0043044; GO:0034725; GO:0071778; GO:0005721; GO:0003682; GO:0048096; GO:0000793; GO:0006302; GO:0003007; GO:0070577; GO:0035173; GO:0004715; GO:0032947; GO:0004713; GO:0006351; GO:0071884; GO:0008270 O60264 "ATP binding; ATP-dependent chromatin remodeling; DNA replication-dependent nucleosome disassembly; WINAC complex; centromeric heterochromatin; chromatin binding; chromatin-mediated maintenance of transcription; condensed chromosome; double-strand break repair; heart morphogenesis; histone acetyl-lysine binding; histone kinase activity; non-membrane spanning protein tyrosine kinase activity; protein complex scaffold; protein tyrosine kinase activity; transcription, DNA-dependent; vitamin D receptor activator activity; zinc ion binding" IPR001487; IPR018359; IPR018500; IPR018501; IPR013136; IPR019786; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) BAZ1B WBSC10 WBSCR10 WBSCR9 WSTF Homo sapiens (Human) TR31833_c4_g1_i4 Q03330 GCN5_YEAST 6.00E-18 GO:0005671; GO:0010484; GO:0000124; GO:0046695; GO:0000775; GO:0005829; GO:0070577; GO:0032968; GO:0034401; GO:0003713; GO:0006351 Q02336; Q12060; Q00772 "Ada2/Gcn5/Ada3 transcription activator complex; H3 histone acetyltransferase activity; SAGA complex; SLIK (SAGA-like) complex; chromosome, centromeric region; cytosol; histone acetyl-lysine binding; positive regulation of transcription elongation from RNA polymerase II promoter; regulation of transcription by chromatin organization; transcription coactivator activity; transcription, DNA-dependent" IPR016181; IPR001487; IPR018359; IPR000182; Histone acetyltransferase GCN5 (EC 2.3.1.48) GCN5 ADA4 SWI9 YGR252W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR31833_c4_g2_i1 Q9UIG0 BAZ1B_HUMAN 1.00E-47 GO:0005524; GO:0043044; GO:0034725; GO:0071778; GO:0005721; GO:0003682; GO:0048096; GO:0000793; GO:0006302; GO:0003007; GO:0070577; GO:0035173; GO:0004715; GO:0032947; GO:0004713; GO:0006351; GO:0071884; GO:0008270 O60264 "ATP binding; ATP-dependent chromatin remodeling; DNA replication-dependent nucleosome disassembly; WINAC complex; centromeric heterochromatin; chromatin binding; chromatin-mediated maintenance of transcription; condensed chromosome; double-strand break repair; heart morphogenesis; histone acetyl-lysine binding; histone kinase activity; non-membrane spanning protein tyrosine kinase activity; protein complex scaffold; protein tyrosine kinase activity; transcription, DNA-dependent; vitamin D receptor activator activity; zinc ion binding" IPR001487; IPR018359; IPR018500; IPR018501; IPR013136; IPR019786; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) BAZ1B WBSC10 WBSCR10 WBSCR9 WSTF Homo sapiens (Human) TR31836_c2_g1_i2 Q68CJ6 SLIP_HUMAN 8.00E-28 GO:0005525; GO:0006184; GO:0003924; GO:0005634 GTP binding; GTP catabolic process; GTPase activity; nucleus IPR001401; IPR027417; Nuclear GTPase SLIP-GC (EC 3.6.1.-) (Speckled-like pattern in the germinal center) NUGGC C8orf80 HMFN0672 Homo sapiens (Human) TR31837_c2_g1_i1 Q9VHN6 RM19_DROME 8.00E-70 GO:0005762; GO:0003735; GO:0006412 mitochondrial large ribosomal subunit; structural constituent of ribosome; translation IPR001857; IPR008991; "39S ribosomal protein L19, mitochondrial (L19mt) (MRP-L19)" mRpL19 CG8039 Drosophila melanogaster (Fruit fly) TR31838_c0_g1_i1 O07552 NHAX_BACSU 2.00E-10 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Stress response protein NhaX nhaX yheK BSU09690 Bacillus subtilis (strain 168) TR31838_c0_g1_i2 O07552 NHAX_BACSU 6.00E-10 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Stress response protein NhaX nhaX yheK BSU09690 Bacillus subtilis (strain 168) TR3184_c0_g1_i1 P0C6F1 DYH2_MOUSE 3.00E-37 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR026976; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 2, axonemal (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2)" Dnah2 Dnahc2 Mus musculus (Mouse) TR31841_c1_g2_i1 Q9Y5Y6 ST14_HUMAN 2.00E-10 GO:0005576; GO:0019897; GO:0005887; GO:0006508; GO:0004252; GO:0008236 extracellular region; extrinsic to plasma membrane; integral to plasma membrane; proteolysis; serine-type endopeptidase activity; serine-type peptidase activity IPR000859; IPR023415; IPR002172; IPR001254; IPR018114; IPR017051; IPR000082; IPR009003; Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein) ST14 PRSS14 SNC19 TADG15 Homo sapiens (Human) TR31841_c1_g3_i1 P98167 SSPO_BOVIN 4.00E-18 GO:0007155; GO:0005615; GO:0010466; GO:0030414 cell adhesion; extracellular space; negative regulation of peptidase activity; peptidase inhibitor activity IPR000421; IPR006207; IPR008979; IPR001545; IPR023415; IPR002172; IPR008037; IPR000884; IPR002919; IPR014853; IPR006552; IPR001007; IPR001846; SCO-spondin SSPO Bos taurus (Bovine) TR31841_c1_g4_i1 P05156 CFAI_HUMAN 1.00E-06 GO:0006958; GO:0005576; GO:0005615; GO:0045087; GO:0016020; GO:0046872; GO:0006508; GO:0030449; GO:0005044; GO:0004252 "complement activation, classical pathway; extracellular region; extracellular space; innate immune response; membrane; metal ion binding; proteolysis; regulation of complement activation; scavenger receptor activity; serine-type endopeptidase activity" IPR003884; IPR002350; IPR023415; IPR002172; IPR001254; IPR018114; IPR001314; IPR001190; IPR017448; IPR009003; Complement factor I (EC 3.4.21.45) (C3B/C4B inactivator) [Cleaved into: Complement factor I heavy chain; Complement factor I light chain] CFI IF Homo sapiens (Human) TR31842_c0_g1_i1 Q5CZL8 CYBR1_XENTR 3.00E-46 GO:0016021; GO:0046872; GO:0016491 integral to membrane; metal ion binding; oxidoreductase activity IPR006593; IPR004877; Cytochrome b reductase 1 (EC 1.-.-.-) cybrd1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31842_c0_g1_i2 Q95245 CY561_PIG 7.00E-64 GO:0016021; GO:0046872; GO:0055114; GO:0030658 integral to membrane; metal ion binding; oxidation-reduction process; transport vesicle membrane IPR006593; IPR004877; Cytochrome b561 (Cytochrome b-561) CYB561 Sus scrofa (Pig) TR31843_c2_g1_i1 P74897 YQA3_THEAQ 1.00E-07 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein in QAH/OAS sulfhydrylase 3'region (USP) Thermus aquaticus TR31844_c0_g1_i1 Q54BM3 MCFG_DICDI 1.00E-59 GO:0016021; GO:0005743; GO:0006810 integral to membrane; mitochondrial inner membrane; transport IPR018108; IPR023395; Mitochondrial substrate carrier family protein G (Solute carrier family 25 member 20 homolog A) mcfG slc25a20A DDB_G0293556 Dictyostelium discoideum (Slime mold) TR31844_c0_g1_i2 Q9Z2Z6 MCAT_MOUSE 1.00E-144 GO:0016021; GO:0005743; GO:0006810 integral to membrane; mitochondrial inner membrane; transport IPR018108; IPR023395; Mitochondrial carnitine/acylcarnitine carrier protein (Carnitine/acylcarnitine translocase) (CAC) (mCAC) (Solute carrier family 25 member 20) Slc25a20 Cac Cact Mus musculus (Mouse) TR31845_c0_g1_i2 Q8TBY9 WDR66_HUMAN 0 GO:0005509 calcium ion binding IPR011992; IPR011047; IPR015943; IPR001680; IPR017986; WD repeat-containing protein 66 WDR66 Homo sapiens (Human) TR31845_c1_g1_i1 Q2TAF3 EMAL4_XENLA 4.00E-09 GO:0005737; GO:0005874 cytoplasm; microtubule IPR005108; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; Echinoderm microtubule-associated protein-like 4 (EMAP-4) eml4 Xenopus laevis (African clawed frog) TR31847_c2_g1_i2 P17133 RU17_DROME 6.00E-62 GO:0005685; GO:0071013; GO:0003729; GO:0000398; GO:0007052; GO:0048025; GO:0022008; GO:0016607; GO:0000166; GO:0071011; GO:0000381 "U1 snRNP; catalytic step 2 spliceosome; mRNA binding; mRNA splicing, via spliceosome; mitotic spindle organization; negative regulation of mRNA splicing, via spliceosome; neurogenesis; nuclear speck; nucleotide binding; precatalytic spliceosome; regulation of alternative mRNA splicing, via spliceosome" IPR012677; IPR000504; IPR022023; U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) snRNP-U1-70K snRNP27D snRNP70K CG8749 Drosophila melanogaster (Fruit fly) TR31849_c1_g2_i1 Q6NZ07 NCLN_DANRE 0 GO:0005789; GO:0016021; GO:0007275; GO:1900176; GO:0008233; GO:0005886; GO:0006508 endoplasmic reticulum membrane; integral to membrane; multicellular organismal development; negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; peptidase activity; plasma membrane; proteolysis IPR016574; IPR007484; Nicalin-1 (Nicastrin-like protein 1) ncl1 Danio rerio (Zebrafish) (Brachydanio rerio) TR31850_c1_g1_i1 O01761 UNC89_CAEEL 1.00E-17 GO:0005524; GO:0031430; GO:0005089; GO:0005543; GO:0004672; GO:0035023; GO:0030241 ATP binding; M band; Rho guanyl-nucleotide exchange factor activity; phospholipid binding; protein kinase activity; regulation of Rho protein signal transduction; skeletal muscle myosin thick filament assembly IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR007850; IPR001452; Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans TR31850_c1_g1_i2 Q96JA1 LRIG1_HUMAN 7.00E-30 GO:0016021 integral to membrane IPR000483; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) LRIG1 LIG1 Homo sapiens (Human) TR31850_c1_g1_i3 Q92626 PXDN_HUMAN 5.00E-20 GO:0005783; GO:0031012; GO:0030198; GO:0005201; GO:0005615; GO:0020037; GO:0042744; GO:0006955; GO:0005152; GO:0046872; GO:0004601; GO:0005578 endoplasmic reticulum; extracellular matrix; extracellular matrix organization; extracellular matrix structural constituent; extracellular space; heme binding; hydrogen peroxide catabolic process; immune response; interleukin-1 receptor antagonist activity; metal ion binding; peroxidase activity; proteinaceous extracellular matrix IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; IPR001007; Peroxidasin homolog (EC 1.11.1.7) (Melanoma-associated antigen MG50) (Vascular peroxidase 1) (p53-responsive gene 2 protein) PXDN KIAA0230 MG50 PRG2 VPO VPO1 Homo sapiens (Human) TR31851_c0_g1_i2 Q3U3R4 LMF1_MOUSE 2.00E-139 GO:0006888; GO:0034382; GO:0005789; GO:0016021; GO:0051006; GO:0033578; GO:0051604; GO:0009306; GO:0090181; GO:0090207 ER to Golgi vesicle-mediated transport; chylomicron remnant clearance; endoplasmic reticulum membrane; integral to membrane; positive regulation of lipoprotein lipase activity; protein glycosylation in Golgi; protein maturation; protein secretion; regulation of cholesterol metabolic process; regulation of triglyceride metabolic process IPR009613; Lipase maturation factor 1 (Transmembrane protein 112) Lmf1 Tmem112 Mus musculus (Mouse) TR31853_c0_g1_i1 P42297 YXIE_BACSU 2.00E-08 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein YxiE (USP YxiE) yxiE BSU39250 N17E Bacillus subtilis (strain 168) TR31853_c0_g3_i2 P72745 Y1101_SYNY3 1.00E-08 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein Slr1101 (USP Slr1101) slr1101 Synechocystis sp. (strain PCC 6803 / Kazusa) TR31854_c12_g2_i1 Q6TXF1 ARRD3_RAT 1.00E-92 GO:0005737 cytoplasm IPR011021; IPR011022; IPR014756; Arrestin domain-containing protein 3 (Liver regeneration-related protein LRRG00048) Arrdc3 Rattus norvegicus (Rat) TR31854_c8_g1_i1 Q9VFD5 FEM1A_DROME 5.00E-12 GO:0051438; GO:0004842 regulation of ubiquitin-protein ligase activity; ubiquitin-protein ligase activity IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog CG6966 CG6966 Drosophila melanogaster (Fruit fly) TR31856_c1_g1_i3 Q49AR2 CE022_HUMAN 5.00E-66 IPR024131; UPF0489 protein C5orf22 C5orf22 Homo sapiens (Human) TR31857_c0_g1_i2 Q6DGU5 S2546_DANRE 9.00E-105 GO:0016021; GO:0005743; GO:0006810 integral to membrane; mitochondrial inner membrane; transport IPR018108; IPR023395; Solute carrier family 25 member 46 slc25a46 si:ch211-220b11.2 zgc:92767 Danio rerio (Zebrafish) (Brachydanio rerio) TR31857_c0_g1_i3 Q6DGU5 S2546_DANRE 2.00E-60 GO:0016021; GO:0005743; GO:0006810 integral to membrane; mitochondrial inner membrane; transport IPR018108; IPR023395; Solute carrier family 25 member 46 slc25a46 si:ch211-220b11.2 zgc:92767 Danio rerio (Zebrafish) (Brachydanio rerio) TR31858_c0_g1_i1 Q8YTC2 Y2800_NOSS1 2.00E-07 GO:0043531; GO:0006952; GO:0006355 "ADP binding; defense response; regulation of transcription, DNA-dependent" IPR000767; IPR020472; IPR002182; IPR027417; IPR027728; IPR015943; IPR001680; IPR019775; IPR017986; Uncharacterized WD repeat-containing protein alr2800 alr2800 Nostoc sp. (strain PCC 7120 / UTEX 2576) TR31859_c1_g1_i1 Q9HB96 FANCE_HUMAN 4.00E-15 GO:0006281; GO:0043240 Q00597 DNA repair; Fanconi anaemia nuclear complex IPR021025; Fanconi anemia group E protein (Protein FACE) FANCE FACE Homo sapiens (Human) TR31861_c1_g1_i1 Q5R8V2 F16A2_PONAB 4.00E-27 GO:0070695; GO:0045022; GO:0007032; GO:0008333; GO:0007040; GO:0015031 FHF complex; early endosome to late endosome transport; endosome organization; endosome to lysosome transport; lysosome organization; protein transport IPR019384; FTS and Hook-interacting protein (FHIP) (Protein FAM160A2) FAM160A2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR31861_c1_g1_i2 Q17AI4 U518_AEDAE 1.00E-08 IPR019384; UPF0518 protein AAEL005291 AAEL005291 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR31862_c0_g1_i1 Q9D9K3 AVEN_MOUSE 1.00E-07 GO:0006915; GO:0012505; GO:0005622; GO:0016020; GO:0043066 apoptotic process; endomembrane system; intracellular; membrane; negative regulation of apoptotic process IPR026187; Cell death regulator Aven Aven Mus musculus (Mouse) TR31862_c0_g1_i5 Q9D9K3 AVEN_MOUSE 2.00E-07 GO:0006915; GO:0012505; GO:0005622; GO:0016020; GO:0043066 apoptotic process; endomembrane system; intracellular; membrane; negative regulation of apoptotic process IPR026187; Cell death regulator Aven Aven Mus musculus (Mouse) TR31863_c0_g1_i1 Q96NG3 TTC25_HUMAN 7.00E-24 GO:0005737 cytoplasm IPR011990; IPR019734; Tetratricopeptide repeat protein 25 (TPR repeat protein 25) TTC25 Homo sapiens (Human) TR31863_c0_g2_i1 Q7ZU45 TTC25_DANRE 3.00E-22 IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 25 (TPR repeat protein 25) ttc25 Danio rerio (Zebrafish) (Brachydanio rerio) TR31864_c1_g1_i1 Q9I928 FUCL4_ANGJA 2.00E-06 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-4 Anguilla japonica (Japanese eel) TR31864_c1_g1_i2 Q9I926 FUCL6_ANGJA 1.00E-07 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-6 Anguilla japonica (Japanese eel) TR31864_c2_g1_i1 Q6P4H8 F173B_HUMAN 4.00E-59 GO:0016021 integral to membrane IPR026170; Protein FAM173B FAM173B Homo sapiens (Human) TR31867_c1_g1_i1 Q5IS99 CASP3_SAIBB 1.00E-37 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Saimiri boliviensis boliviensis (Bolivian squirrel monkey) TR31867_c1_g1_i2 Q98943 CASP2_CHICK 3.00E-27 GO:0006915; GO:0004197; GO:0005622; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; intracellular; proteolysis; regulation of apoptotic process IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) TR31867_c1_g1_i3 P42575 CASP2_HUMAN 3.00E-28 GO:0006977; GO:0007568; GO:0097190; GO:0007420; GO:0071260; GO:0004197; GO:0005829; GO:0019899; GO:0097194; GO:0001554; GO:0016020; GO:0005739; GO:0003407; GO:0048011; GO:0005634; GO:0043065; GO:0043525; GO:0016485; GO:0006508; GO:0043281 P42575-1; P78560; P78527 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; aging; apoptotic signaling pathway; brain development; cellular response to mechanical stimulus; cysteine-type endopeptidase activity; cytosol; enzyme binding; execution phase of apoptosis; luteolysis; membrane; mitochondrion; neural retina development; neurotrophin TRK receptor signaling pathway; nucleus; positive regulation of apoptotic process; positive regulation of neuron apoptotic process; protein processing; proteolysis; regulation of cysteine-type endopeptidase activity involved in apoptotic process" IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 NEDD2 Homo sapiens (Human) TR31867_c1_g1_i4 Q5IS54 CASP3_PANTR 1.00E-35 GO:0001782; GO:0043029; GO:0006309; GO:0004190; GO:0045165; GO:0071310; GO:0004861; GO:0004197; GO:0005829; GO:0008625; GO:0007507; GO:0008631; GO:0030216; GO:0005739; GO:0030889; GO:0046007; GO:0043066; GO:0045736; GO:0051402; GO:0030264; GO:0005634; GO:0043525; GO:0016485; GO:0006508; GO:0001836; GO:0006974; GO:0009411; GO:0009611; GO:0007605 B cell homeostasis; T cell homeostasis; apoptotic DNA fragmentation; aspartic-type endopeptidase activity; cell fate commitment; cellular response to organic substance; cyclin-dependent protein serine/threonine kinase inhibitor activity; cysteine-type endopeptidase activity; cytosol; extrinsic apoptotic signaling pathway via death domain receptors; heart development; intrinsic apoptotic signaling pathway in response to oxidative stress; keratinocyte differentiation; mitochondrion; negative regulation of B cell proliferation; negative regulation of activated T cell proliferation; negative regulation of apoptotic process; negative regulation of cyclin-dependent protein serine/threonine kinase activity; neuron apoptotic process; nuclear fragmentation involved in apoptotic nuclear change; nucleus; positive regulation of neuron apoptotic process; protein processing; proteolysis; release of cytochrome c from mitochondria; response to DNA damage stimulus; response to UV; response to wounding; sensory perception of sound IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Pan troglodytes (Chimpanzee) TR31867_c1_g1_i5 Q8MJC3 CASP3_RABIT 4.00E-35 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Oryctolagus cuniculus (Rabbit) TR31870_c1_g1_i2 Q9NX08 COMD8_HUMAN 5.00E-40 IPR017920; IPR009886; COMM domain-containing protein 8 COMMD8 MDS022 Homo sapiens (Human) TR31871_c0_g1_i1 Q6DC04 CARM1_DANRE 0 GO:0005829; GO:0070577; GO:0035642; GO:0030374; GO:0005634; GO:0009405; GO:0045600; GO:0035242; GO:0033146; GO:0048742; GO:0006355; GO:0044212; GO:0006351 "cytosol; histone acetyl-lysine binding; histone methyltransferase activity (H3-R17 specific); ligand-dependent nuclear receptor transcription coactivator activity; nucleus; pathogenesis; positive regulation of fat cell differentiation; protein-arginine omega-N asymmetric methyltransferase activity; regulation of intracellular estrogen receptor signaling pathway; regulation of skeletal muscle fiber development; regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR025799; IPR025797; IPR020989; Histone-arginine methyltransferase CARM1 (EC 2.1.1.-) (EC 2.1.1.125) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4) carm1 si:dkey-204f11.63 zgc:100805 Danio rerio (Zebrafish) (Brachydanio rerio) TR31871_c0_g1_i2 Q9WVG6 CARM1_MOUSE 0 GO:0005829; GO:0060350; GO:0034970; GO:0070577; GO:0035642; GO:0030520; GO:0030374; GO:0032091; GO:0005634; GO:0009405; GO:0008284; GO:0045600; GO:0035242; GO:0003420; GO:0033146; GO:0006355; GO:0044212; GO:0006351 P68433 "cytosol; endochondral bone morphogenesis; histone H3-R2 methylation; histone acetyl-lysine binding; histone methyltransferase activity (H3-R17 specific); intracellular estrogen receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; negative regulation of protein binding; nucleus; pathogenesis; positive regulation of cell proliferation; positive regulation of fat cell differentiation; protein-arginine omega-N asymmetric methyltransferase activity; regulation of growth plate cartilage chondrocyte proliferation; regulation of intracellular estrogen receptor signaling pathway; regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR025799; IPR025797; IPR020989; Histone-arginine methyltransferase CARM1 (EC 2.1.1.-) (EC 2.1.1.125) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4) Carm1 Prmt4 Mus musculus (Mouse) TR31872_c0_g1_i2 Q7ZVS8 FTSJ1_DANRE 4.00E-100 GO:0006370; GO:0097310; GO:0005737; GO:0016021; GO:0004483; GO:0005634 7-methylguanosine mRNA capping; cap2 mRNA methylation; cytoplasm; integral to membrane; mRNA (nucleoside-2'-O-)-methyltransferase activity; nucleus IPR025807; IPR002877; Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.-) (Cap methyltransferase 2) (Cap2 2'O-ribose methyltransferase 2) (MTr2) (FtsJ methyltransferase domain-containing protein 1) cmtr2 ftsjd1 zgc:55686 Danio rerio (Zebrafish) (Brachydanio rerio) TR31872_c0_g1_i3 Q8IYT2 FTSJ1_HUMAN 2.00E-105 GO:0006370; GO:0097310; GO:0005737; GO:0016021; GO:0004483; GO:0005634 7-methylguanosine mRNA capping; cap2 mRNA methylation; cytoplasm; integral to membrane; mRNA (nucleoside-2'-O-)-methyltransferase activity; nucleus IPR025807; IPR002877; Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.-) (Cap methyltransferase 2) (Cap2 2'O-ribose methyltransferase 2) (HMTr2) (MTr2) (FtsJ methyltransferase domain-containing protein 1) (Protein adrift homolog) CMTR2 AFT FTSJD1 Homo sapiens (Human) TR31873_c1_g2_i1 Q99973 TEP1_HUMAN 4.00E-100 GO:0005524; GO:0003723; GO:0000781; GO:0005737; GO:0016363; GO:0005697; GO:0000722 "ATP binding; RNA binding; chromosome, telomeric region; cytoplasm; nuclear matrix; telomerase holoenzyme complex; telomere maintenance via recombination" IPR025139; IPR007111; IPR027417; IPR008850; IPR008858; IPR015943; IPR001680; IPR019775; IPR017986; Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog) TEP1 TLP1 TP1 Homo sapiens (Human) TR31873_c1_g2_i2 Q6CG48 LIS1_YARLI 2.00E-12 GO:0051301; GO:0006928; GO:0005737; GO:0000132; GO:0005874; GO:0005875; GO:0007067; GO:0000922; GO:0006810 cell division; cellular component movement; cytoplasm; establishment of mitotic spindle orientation; microtubule; microtubule associated complex; mitosis; spindle pole; transport IPR017252; IPR020472; IPR015943; IPR001680; IPR017986; Nuclear distribution protein PAC1 (Lissencephaly-1 homolog) (LIS-1) (nudF homolog) PAC1 LIS1 YALI0B00902g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR31875_c10_g1_i1 Q96LD4 TRI47_HUMAN 2.00E-06 GO:0005737; GO:0005634; GO:0008270 cytoplasm; nucleus; zinc ion binding IPR001870; IPR008985; IPR006574; IPR003877; IPR000315; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100) TRIM47 GOA RNF100 Homo sapiens (Human) TR31878_c0_g2_i2 Q9VAL0 SPCS1_DROME 5.00E-23 GO:0016021; GO:0008233; GO:0006508; GO:0005787; GO:0006465 integral to membrane; peptidase activity; proteolysis; signal peptidase complex; signal peptide processing IPR009542; Signal peptidase complex subunit 1 (EC 3.4.-.-) (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) Spase12 CG11500 Drosophila melanogaster (Fruit fly) TR31879_c6_g2_i2 A5PJK1 TMPPE_BOVIN 6.00E-52 GO:0016787; GO:0016021; GO:0046872 hydrolase activity; integral to membrane; metal ion binding IPR004843; Transmembrane protein with metallophosphoesterase domain (EC 3.1.-.-) TMPPE Bos taurus (Bovine) TR31879_c6_g2_i3 O34870 YKUE_BACSU 4.00E-07 GO:0016787; GO:0046872 hydrolase activity; metal ion binding IPR004843; IPR006311; Uncharacterized metallophosphoesterase YkuE ykuE BSU14050 Bacillus subtilis (strain 168) TR31879_c6_g2_i4 A5PJK1 TMPPE_BOVIN 3.00E-52 GO:0016787; GO:0016021; GO:0046872 hydrolase activity; integral to membrane; metal ion binding IPR004843; Transmembrane protein with metallophosphoesterase domain (EC 3.1.-.-) TMPPE Bos taurus (Bovine) TR3188_c0_g1_i1 Q9QXZ7 NR2E3_MOUSE 1.00E-24 GO:0042462; GO:0030522; GO:0004879; GO:0008285; GO:0000122; GO:0005634; GO:0045872; GO:0045944; GO:0060041; GO:0043565; GO:0003700; GO:0003707; GO:0005667; GO:0008270 eye photoreceptor cell development; intracellular receptor signaling pathway; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of rhodopsin gene expression; positive regulation of transcription from RNA polymerase II promoter; retina development in camera-type eye; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription factor complex; zinc ion binding IPR003068; IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Photoreceptor-specific nuclear receptor (Nuclear receptor subfamily 2 group E member 3) (Retina-specific nuclear receptor) Nr2e3 Pnr Rnr Mus musculus (Mouse) TR31882_c3_g1_i2 Q29RP8 SV421_BOVIN 6.00E-52 GO:0005694; GO:0034773; GO:0042799; GO:0018024; GO:0005634; GO:0006355; GO:0006351 "chromosome; histone H4-K20 trimethylation; histone methyltransferase activity (H4-K20 specific); histone-lysine N-methyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025790; IPR001214; Histone-lysine N-methyltransferase SUV420H1 (EC 2.1.1.43) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1) SUV420H1 Bos taurus (Bovine) TR31884_c0_g2_i1 Q08BC4 STPG2_DANRE 5.00E-88 IPR010736; Sperm-tail PG-rich repeat-containing protein 2 stpg2 zgc:153987 Danio rerio (Zebrafish) (Brachydanio rerio) TR31888_c0_g1_i1 Q9NUD7 CT096_HUMAN 7.00E-15 Uncharacterized protein C20orf96 C20orf96 Homo sapiens (Human) TR31889_c7_g2_i1 P31508 ESCA_APIME 2.00E-12 GO:0003677; GO:0046872; GO:0005634 DNA binding; metal ion binding; nucleus IPR007087; IPR015880; IPR013087; Escargot/snail protein homolog (Fragment) Apis mellifera (Honeybee) TR31889_c7_g2_i4 Q10938 YWS2_CAEEL 6.00E-09 GO:0003677; GO:0046872; GO:0005634 DNA binding; metal ion binding; nucleus IPR007087; IPR015880; IPR013087; Putative zinc finger protein B0310.2 B0310.2 Caenorhabditis elegans TR31889_c7_g2_i5 Q8TDD2 SP7_HUMAN 5.00E-14 GO:0017151; GO:0003677; GO:0005737; GO:0060218; GO:0046872; GO:0005634; GO:0001649; GO:2000738; GO:0045944; GO:0006351 "DEAD/H-box RNA helicase binding; DNA binding; cytoplasm; hematopoietic stem cell differentiation; metal ion binding; nucleus; osteoblast differentiation; positive regulation of stem cell differentiation; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Transcription factor Sp7 (Zinc finger protein osterix) SP7 OSX Homo sapiens (Human) TR31889_c7_g3_i1 O60384 ZN861_HUMAN 3.00E-08 GO:0046872; GO:0003676 metal ion binding; nucleic acid binding IPR007087; IPR013087; Putative zinc finger protein 861 ZNF861P Homo sapiens (Human) TR31889_c7_g3_i2 Q9JKD9 ZBT32_MOUSE 5.00E-16 GO:0003677; GO:0042098; GO:0030097; GO:0000228; GO:0001817; GO:0006355; GO:0003714; GO:0006351; GO:0008270 "DNA binding; T cell proliferation; hemopoiesis; nuclear chromosome; regulation of cytokine production; regulation of transcription, DNA-dependent; transcription corepressor activity; transcription, DNA-dependent; zinc ion binding" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 32 (Repressor of GATA) (Testis zinc finger protein) Zbtb32 Rog Tzfp Mus musculus (Mouse) TR31889_c9_g1_i1 Q5EAC5 ZN410_BOVIN 2.00E-37 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 410 ZNF410 Bos taurus (Bovine) TR31889_c9_g1_i2 O57311 ZIC3_XENLA 2.00E-25 GO:0005737; GO:0007368; GO:0000578; GO:0046872; GO:0007399; GO:0014034; GO:0005634; GO:0045944; GO:0043565; GO:0003700; GO:0006351 "cytoplasm; determination of left/right symmetry; embryonic axis specification; metal ion binding; nervous system development; neural crest cell fate commitment; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein ZIC 3 (XZic3) (XlZic3) (Zinc finger protein Zic3-A) (Zinc finger protein of the cerebellum 3) zic3 zic3-a Xenopus laevis (African clawed frog) TR31889_c9_g1_i3 Q96T25 ZIC5_HUMAN 1.00E-24 GO:0003677; GO:0030154; GO:0030900; GO:0046872; GO:0001843; GO:0005634; GO:0006355; GO:0003700 "DNA binding; cell differentiation; forebrain development; metal ion binding; neural tube closure; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity" IPR007087; IPR015880; IPR013087; Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5) ZIC5 Homo sapiens (Human) TR31889_c9_g3_i1 Q91VN1 ZNF24_MOUSE 2.00E-29 GO:0046872; GO:0042552; GO:0045892; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "metal ion binding; myelination; negative regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein 24 (Hypomyelinated CNS protein) (Zinc finger protein 191) (Zfp-191) (Zinc finger protein ZF-12) Znf24 Hmcns Zfp191 Mus musculus (Mouse) TR31889_c9_g3_i2 A6NK53 ZN233_HUMAN 2.00E-49 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 233 ZNF233 Homo sapiens (Human) TR31889_c9_g3_i3 Q96NI8 ZN570_HUMAN 3.00E-46 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 570 ZNF570 Homo sapiens (Human) TR31889_c9_g4_i1 A6NK53 ZN233_HUMAN 1.00E-44 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 233 ZNF233 Homo sapiens (Human) TR31889_c9_g4_i2 Q3MJ62 ZSC23_HUMAN 6.00E-37 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 23 (Zinc finger protein 390) (Zinc finger protein 453) ZSCAN23 ZNF390 ZNF453 Homo sapiens (Human) TR31889_c9_g4_i3 Q60636 PRDM1_MOUSE 3.00E-34 GO:0003677; GO:0045165; GO:0005737; GO:0042462; GO:0007281; GO:0042826; GO:0001893; GO:0046872; GO:0008168; GO:0007275; GO:0030889; GO:0031665; GO:0000122; GO:0005634; GO:0045579; GO:0010628; GO:0006355; GO:0043565; GO:0006351; GO:0060707 P63165 "DNA binding; cell fate commitment; cytoplasm; eye photoreceptor cell development; germ cell development; histone deacetylase binding; maternal placenta development; metal ion binding; methyltransferase activity; multicellular organismal development; negative regulation of B cell proliferation; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of B cell differentiation; positive regulation of gene expression; regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription, DNA-dependent; trophoblast giant cell differentiation" IPR001214; IPR007087; IPR015880; IPR013087; IPR016608; PR domain zinc finger protein 1 (EC 2.1.1.-) (B lymphocyte-induced maturation protein 1) (Blimp-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) Prdm1 Blimp1 Mus musculus (Mouse) TR31889_c9_g4_i4 O75626 PRDM1_HUMAN 2.00E-33 GO:0045165; GO:0005737; GO:0001892; GO:0042462; GO:0007281; GO:0001893; GO:0046872; GO:0008168; GO:0030889; GO:0031665; GO:0000122; GO:0005634; GO:0045579; GO:0010628; GO:0043565; GO:0003700; GO:0006351 O75925; P63165 "cell fate commitment; cytoplasm; embryonic placenta development; eye photoreceptor cell development; germ cell development; maternal placenta development; metal ion binding; methyltransferase activity; negative regulation of B cell proliferation; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of B cell differentiation; positive regulation of gene expression; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001214; IPR007087; IPR015880; IPR013087; IPR016608; PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1) PRDM1 BLIMP1 Homo sapiens (Human) TR31894_c2_g1_i1 P04041 GPX1_RAT 8.00E-34 GO:0007568; GO:0005829; GO:0043295; GO:0006749; GO:0004602; GO:0042744; GO:0005634; GO:0047066; GO:0032355; GO:0051593; GO:0009749; GO:0006982; GO:0035094; GO:0010269; GO:0008430 aging; cytosol; glutathione binding; glutathione metabolic process; glutathione peroxidase activity; hydrogen peroxide catabolic process; nucleus; phospholipid-hydroperoxide glutathione peroxidase activity; response to estradiol stimulus; response to folic acid; response to glucose stimulus; response to lipid hydroperoxide; response to nicotine; response to selenium ion; selenium binding IPR000889; IPR012336; Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase) Gpx1 Rattus norvegicus (Rat) TR31894_c2_g1_i2 Q95003 GPX3_CAEEL 3.00E-45 GO:0005615; GO:0004602; GO:0006979 extracellular space; glutathione peroxidase activity; response to oxidative stress IPR000889; IPR012336; Glutathione peroxidase 3 (EC 1.11.1.9) gpx-3 C11E4.2 Caenorhabditis elegans TR31894_c3_g2_i10 Q3SZ36 TMM18_BOVIN 2.00E-26 GO:0003677; GO:0016477; GO:0005737; GO:0016021; GO:0031965; GO:0006351 "DNA binding; cell migration; cytoplasm; integral to membrane; nuclear membrane; transcription, DNA-dependent" IPR026721; Transmembrane protein 18 TMEM18 Bos taurus (Bovine) TR31894_c3_g2_i5 Q641M3 TMM18_DANRE 2.00E-28 GO:0003677; GO:0016021; GO:0031965 DNA binding; integral to membrane; nuclear membrane IPR026721; Transmembrane protein 18 tmem18 zgc:101011 Danio rerio (Zebrafish) (Brachydanio rerio) TR31895_c0_g2_i3 Q8N6F8 WBS27_HUMAN 2.00E-18 Williams-Beuren syndrome chromosomal region 27 protein WBSCR27 Homo sapiens (Human) TR31896_c2_g2_i1 O60931 CTNS_HUMAN 2.00E-101 GO:0046034; GO:0015184; GO:0015811; GO:0007628; GO:0007420; GO:0050890; GO:0048058; GO:0006749; GO:0007625; GO:0016021; GO:0005770; GO:0007616; GO:0005765; GO:0005764; GO:0005886; GO:0008542 ATP metabolic process; L-cystine transmembrane transporter activity; L-cystine transport; adult walking behavior; brain development; cognition; compound eye corneal lens development; glutathione metabolic process; grooming behavior; integral to membrane; late endosome; long-term memory; lysosomal membrane; lysosome; plasma membrane; visual learning IPR006603; IPR005282; Cystinosin CTNS Homo sapiens (Human) TR31896_c2_g2_i3 Q9VCR7 CTNS_DROME 5.00E-92 GO:0015171; GO:0016021; GO:0005765 amino acid transmembrane transporter activity; integral to membrane; lysosomal membrane IPR006603; IPR005282; IPR010916; Cystinosin homolog CG17119 Drosophila melanogaster (Fruit fly) TR31896_c2_g2_i4 A7MB63 CTNS_BOVIN 3.00E-98 GO:0015184; GO:0007628; GO:0048058; GO:0007625; GO:0016021; GO:0007616; GO:0005765; GO:0008542 L-cystine transmembrane transporter activity; adult walking behavior; compound eye corneal lens development; grooming behavior; integral to membrane; long-term memory; lysosomal membrane; visual learning IPR006603; IPR005282; Cystinosin CTNS Bos taurus (Bovine) TR31897_c0_g1_i1 Q28FB9 THOC4_XENTR 2.00E-40 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0051028; GO:0016607; GO:0000166 RNA binding; RNA splicing; cytoplasm; mRNA processing; mRNA transport; nuclear speck; nucleotide binding IPR025715; IPR012677; IPR000504; THO complex subunit 4 (Tho4) (Aly/REF export factor) alyref thoc4 TEgg022b23.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31897_c0_g1_i2 Q28FB9 THOC4_XENTR 9.00E-40 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0051028; GO:0016607; GO:0000166 RNA binding; RNA splicing; cytoplasm; mRNA processing; mRNA transport; nuclear speck; nucleotide binding IPR025715; IPR012677; IPR000504; THO complex subunit 4 (Tho4) (Aly/REF export factor) alyref thoc4 TEgg022b23.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31898_c0_g1_i2 Q5R615 RB33B_PONAB 1.00E-99 GO:0005525; GO:0005796; GO:0000139; GO:0006914; GO:0015031; GO:2000785; GO:2000156; GO:0007264 "GTP binding; Golgi lumen; Golgi membrane; autophagy; protein transport; regulation of autophagic vacuole assembly; regulation of retrograde vesicle-mediated transport, Golgi to ER; small GTPase mediated signal transduction" IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-33B RAB33B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR31899_c1_g1_i1 Q09324 GCNT1_MOUSE 3.00E-57 GO:0031985; GO:0000139; GO:0003829; GO:0060352; GO:0009101; GO:0016021; GO:0060993; GO:0050901; GO:0006486; GO:0048729 "Golgi cisterna; Golgi membrane; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; cell adhesion molecule production; glycoprotein biosynthetic process; integral to membrane; kidney morphogenesis; leukocyte tethering or rolling; protein glycosylation; tissue morphogenesis" IPR003406; Protein modification; protein glycosylation. "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (Core 2-branching enzyme) (Core2-GlcNAc-transferase) (C2GNT)" Gcnt1 Mus musculus (Mouse) TR31903_c1_g1_i1 Q24733 ACT_DICVI 2.00E-14 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; Actin (Fragment) Dictyocaulus viviparus (Bovine lungworm) TR31903_c1_g2_i1 Q25381 ACTM_LYTPI 3.00E-70 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; "Actin, muscle (LPM) (Fragment)" Lytechinus pictus (Painted sea urchin) TR31903_c1_g2_i2 Q5AW89 ARP4_EMENI 7.00E-24 GO:0006281; GO:0016568; GO:0005634; GO:0006355; GO:0006351 "DNA repair; chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR004000; Actin-related protein 4 (Actin-like protein arp4) (Actin-like protein 4) arp4 AN7441 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR31903_c1_g2_i3 Q9QZB7 ARP10_MOUSE 3.00E-09 GO:0005737; GO:0005869; GO:0007018 P42025 cytoplasm; dynactin complex; microtubule-based movement IPR004000; IPR027127; Actin-related protein 10 (Actin-related protein 11) Actr10 Act11 Actr11 Arp11 Mus musculus (Mouse) TR31903_c1_g2_i4 P17126 ACT_HYDVU 1.00E-69 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin, non-muscle 6.2" Hydra vulgaris (Hydra) (Hydra attenuata) TR31904_c8_g3_i1 P38279 RTC2_YEAST 1.00E-17 GO:0034488; GO:0015326; GO:0071627; GO:0031966 basic amino acid transmembrane export from vacuole; cationic amino acid transmembrane transporter activity; integral to fungal-type vacuolar membrane; mitochondrial membrane IPR006603; Probable vacuolar amino acid transporter YPQ3 (PQ-loop repeat-containing protein 3) (Protein RTC2) (Restriction of telomere capping protein 2) RTC2 YPQ3 YBR147W YBR1124 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR31904_c8_g3_i2 Q5ZJX0 LAAT1_CHICK 5.00E-35 GO:0015189; GO:0080144; GO:0015181; GO:0031301; GO:0005765 L-lysine transmembrane transporter activity; amino acid homeostasis; arginine transmembrane transporter activity; integral to organelle membrane; lysosomal membrane IPR006603; Lysosomal amino acid transporter 1 homolog (PQ-loop repeat-containing protein 2) PQLC2 RCJMB04_14o18 Gallus gallus (Chicken) TR31907_c1_g1_i1 O88799 ZAN_MOUSE 2.00E-06 GO:0007155; GO:0016021; GO:0005886; GO:2000359 cell adhesion; integral to membrane; plasma membrane; regulation of binding of sperm to zona pellucida IPR008985; IPR000742; IPR013032; IPR003645; IPR000998; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; Zonadhesin Zan Mus musculus (Mouse) TR31907_c2_g1_i2 Q9YH85 TECTA_CHICK 2.00E-06 GO:0031225; GO:0007160; GO:0005886; GO:0005578; GO:0007605 anchored to membrane; cell-matrix adhesion; plasma membrane; proteinaceous extracellular matrix; sensory perception of sound IPR000742; IPR003886; IPR002919; IPR025615; IPR014853; IPR006552; IPR001846; IPR001507; IPR017977; Alpha-tectorin TECTA Gallus gallus (Chicken) TR31907_c3_g2_i1 P80009 PLMN_CANFA 3.00E-15 GO:0006915; GO:0007596; GO:0022617; GO:0005615; GO:0031232; GO:0042730; GO:0060716; GO:0071674; GO:0046716; GO:0045445; GO:0010812; GO:0051918; GO:0051919; GO:0006508; GO:0004252; GO:0042246; GO:0048771; GO:0060707 apoptotic process; blood coagulation; extracellular matrix disassembly; extracellular space; extrinsic to external side of plasma membrane; fibrinolysis; labyrinthine layer blood vessel development; mononuclear cell migration; muscle cell cellular homeostasis; myoblast differentiation; negative regulation of cell-substrate adhesion; negative regulation of fibrinolysis; positive regulation of fibrinolysis; proteolysis; serine-type endopeptidase activity; tissue regeneration; tissue remodeling; trophoblast giant cell differentiation IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR009003; Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Plasmin light chain B] (Fragment) PLG Canis familiaris (Dog) (Canis lupus familiaris) TR31907_c3_g2_i2 P06867 PLMN_PIG 1.00E-60 GO:0007596; GO:0005576; GO:0042730; GO:0006508; GO:0004252; GO:0048771 blood coagulation; extracellular region; fibrinolysis; proteolysis; serine-type endopeptidase activity; tissue remodeling IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Sus scrofa (Pig) TR31907_c3_g2_i3 Q8AXY6 MUSK_CHICK 5.00E-17 GO:0005524; GO:0030154; GO:0030054; GO:0016021; GO:0007275; GO:0018108; GO:0005886; GO:0045211; GO:0008582; GO:0004714 ATP binding; cell differentiation; cell junction; integral to membrane; multicellular organismal development; peptidyl-tyrosine phosphorylation; plasma membrane; postsynaptic membrane; regulation of synaptic growth at neuromuscular junction; transmembrane receptor protein tyrosine kinase activity IPR020067; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000001; IPR013806; IPR018056; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; "Muscle, skeletal receptor tyrosine protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)" MUSK Gallus gallus (Chicken) TR31908_c1_g1_i1 A8E5V9 TM173_XENTR 6.00E-12 GO:0002218; GO:0006915; GO:0061507; GO:0035438; GO:0051607; GO:0005789; GO:0045087; GO:0016021; GO:0032608; GO:0005741; GO:0048471; GO:0005886; GO:0042803 activation of innate immune response; apoptotic process; cyclic-GMP-AMP binding; cyclic-di-GMP binding; defense response to virus; endoplasmic reticulum membrane; innate immune response; integral to membrane; interferon-beta production; mitochondrial outer membrane; perinuclear region of cytoplasm; plasma membrane; protein homodimerization activity Stimulator of interferon genes protein (STING) (Transmembrane protein 173) tmem173 sting Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31909_c0_g3_i1 Q6AXX4 SAS10_RAT 1.00E-41 GO:0007420; GO:0016568; GO:0005730; GO:0005634 brain development; chromatin modification; nucleolus; nucleus IPR007146; IPR018972; Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (Disrupter of silencing SAS10) (UTP3 homolog) Utp3 Crlz1 Sas10 Rattus norvegicus (Rat) TR31912_c0_g2_i1 B6NXD5 BRE_BRAFL 2.00E-89 GO:0070531; GO:0070552; GO:0031572; GO:0006915; GO:0016568; GO:0005737; GO:0006302; GO:0031593; GO:0045739; GO:0010212 BRCA1-A complex; BRISC complex; G2 DNA damage checkpoint; apoptotic process; chromatin modification; cytoplasm; double-strand break repair; polyubiquitin binding; positive regulation of DNA repair; response to ionizing radiation IPR010358; BRCA1-A complex subunit BRE (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein) BRE BRAFLDRAFT_269508 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR31913_c0_g1_i1 H2A0L0 TYRO1_PINMG 1.00E-49 GO:0005576; GO:0046872; GO:0016491 extracellular region; metal ion binding; oxidoreductase activity IPR002227; IPR008922; Tyrosinase-like protein 1 (EC 1.14.18.-) (Tyrosinase 1) Pinctada margaritifera (Black-lipped pearl oyster) TR31914_c0_g1_i1 Q4V7E0 NAP1_RAT 8.00E-63 GO:0016787 hydrolase activity IPR001378; IPR023368; IPR023370; Nef-associated protein 1 (EC 3.1.2.-) (Thioesterase NAP1) Nap1 Rattus norvegicus (Rat) TR31914_c0_g1_i3 Q9BU70 NAP1_HUMAN 7.00E-62 GO:0016787; GO:0019048 hydrolase activity; modulation by virus of host morphology or physiology IPR001378; IPR023368; IPR023370; Nef-associated protein 1 (EC 3.1.2.-) (Thioesterase NAP1) C9orf156 NAP1 HSPC219 Homo sapiens (Human) TR31916_c0_g1_i1 Q9IB83 PSB1B_CARAU 4.00E-96 GO:0005737; GO:0005634; GO:0005839; GO:0051603; GO:0004298 cytoplasm; nucleus; proteasome core complex; proteolysis involved in cellular protein catabolic process; threonine-type endopeptidase activity IPR016050; IPR001353; IPR023333; Proteasome subunit beta type-1-B (EC 3.4.25.1) (20S proteasome beta-6 subunit B) (B6-B) psmb1-B Carassius auratus (Goldfish) TR31918_c2_g1_i1 Q5VUE5 CA053_HUMAN 5.00E-21 Uncharacterized protein C1orf53 C1orf53 Homo sapiens (Human) TR31918_c3_g2_i13 Q8K354 CBR3_MOUSE 5.00E-93 GO:0070402; GO:0004090; GO:0005829; GO:0005634 NADPH binding; carbonyl reductase (NADPH) activity; cytosol; nucleus IPR002198; IPR002347; IPR016040; IPR020904; Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) Cbr3 Mus musculus (Mouse) TR31918_c3_g2_i5 Q8K354 CBR3_MOUSE 4.00E-93 GO:0070402; GO:0004090; GO:0005829; GO:0005634 NADPH binding; carbonyl reductase (NADPH) activity; cytosol; nucleus IPR002198; IPR002347; IPR016040; IPR020904; Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) Cbr3 Mus musculus (Mouse) TR31918_c4_g1_i1 Q9D8P7 TF3C6_MOUSE 3.00E-18 GO:0003677; GO:0000127; GO:0006383 DNA binding; transcription factor TFIIIC complex; transcription from RNA polymerase III promoter IPR019481; General transcription factor 3C polypeptide 6 (Transcription factor IIIC 35 kDa subunit) (TFIIIC 35 kDa subunit) (TFIIIC35) (Transcription factor IIIC subunit 6) Gtf3c6 Mus musculus (Mouse) TR31919_c2_g1_i2 Q68FF9 S5A1_MOUSE 1.00E-77 GO:0003865; GO:0006702; GO:0030154; GO:0047751; GO:0005789; GO:0016021; GO:0007548 3-oxo-5-alpha-steroid 4-dehydrogenase activity; androgen biosynthetic process; cell differentiation; cholestenone 5-alpha-reductase activity; endoplasmic reticulum membrane; integral to membrane; sex differentiation IPR016636; IPR001104; 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC 1.3.1.22) (SR type 1) (Steroid 5-alpha-reductase 1) (S5AR 1) Srd5a1 Mus musculus (Mouse) TR31919_c2_g1_i4 Q55C17 TECR_DICDI 6.00E-19 GO:0030497; GO:0030176; GO:0016627; GO:0006694; GO:0042761 "fatty acid elongation; integral to endoplasmic reticulum membrane; oxidoreductase activity, acting on the CH-CH group of donors; steroid biosynthetic process; very long-chain fatty acid biosynthetic process" IPR001104; "Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2-like protein) (Trans-2,3-enoyl-CoA reductase) (TER)" gpsn2 DDB_G0270270 Dictyostelium discoideum (Slime mold) TR31923_c0_g2_i1 O54873 AIMP1_CRIGR 2.00E-81 GO:0005794; GO:0001525; GO:0006915; GO:0007155; GO:0005829; GO:0005783; GO:0005615; GO:0006006; GO:0006954; GO:0005634; GO:0000049; GO:0006412; GO:0030133 Golgi apparatus; angiogenesis; apoptotic process; cell adhesion; cytosol; endoplasmic reticulum; extracellular space; glucose metabolic process; inflammatory response; nucleus; tRNA binding; translation; transport vesicle IPR012340; IPR002547; Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Multisynthase complex auxiliary component p43) [Cleaved into: Endothelial monocyte-activating polypeptide 2 (EMAP-II) (Small inducible cytokine subfamily E member 1)] AIMP1 SCYE1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR31925_c2_g1_i1 B8JLV7 VMA21_DANRE 4.00E-18 GO:0030127; GO:0005789; GO:0033116; GO:0016021; GO:0070072 COPII vesicle coat; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; vacuolar proton-transporting V-type ATPase complex assembly IPR019013; Vacuolar ATPase assembly integral membrane protein vma21 vma21 si:ch73-26o5.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR31926_c0_g1_i1 Q8TTA0 RCL_METAC 4.00E-25 GO:0070694; GO:0009159; GO:0050144; GO:0009117 deoxyribonucleoside 5'-monophosphate N-glycosidase activity; deoxyribonucleoside monophosphate catabolic process; nucleoside deoxyribosyltransferase activity; nucleotide metabolic process IPR007710; Putative 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (EC 3.2.2.-) MA_0537 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) TR31926_c0_g1_i4 A7RLE5 RCL_NEMVE 5.00E-54 GO:0005737; GO:0070694; GO:0009159; GO:0050144; GO:0009117; GO:0005634; GO:0030307 cytoplasm; deoxyribonucleoside 5'-monophosphate N-glycosidase activity; deoxyribonucleoside monophosphate catabolic process; nucleoside deoxyribosyltransferase activity; nucleotide metabolic process; nucleus; positive regulation of cell growth IPR007710; Putative 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (EC 3.2.2.-) v1g160099 Nematostella vectensis (Starlet sea anemone) TR31926_c0_g1_i5 A7RLE5 RCL_NEMVE 2.00E-54 GO:0005737; GO:0070694; GO:0009159; GO:0050144; GO:0009117; GO:0005634; GO:0030307 cytoplasm; deoxyribonucleoside 5'-monophosphate N-glycosidase activity; deoxyribonucleoside monophosphate catabolic process; nucleoside deoxyribosyltransferase activity; nucleotide metabolic process; nucleus; positive regulation of cell growth IPR007710; Putative 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (EC 3.2.2.-) v1g160099 Nematostella vectensis (Starlet sea anemone) TR31930_c0_g1_i1 Q96C11 FGGY_HUMAN 0 GO:0005975; GO:0008219; GO:0016301; GO:0070050; GO:0016773 "carbohydrate metabolic process; cell death; kinase activity; neuron cellular homeostasis; phosphotransferase activity, alcohol group as acceptor" IPR006003; IPR018485; IPR018484; FGGY carbohydrate kinase domain-containing protein (EC 2.7.1.-) FGGY Homo sapiens (Human) TR31931_c0_g1_i1 Q7ZXH2 NSE2_XENLA 5.00E-31 GO:0016605; GO:0019789; GO:0030915; GO:0051301; GO:0090398; GO:0000781; GO:0000724; GO:0046872; GO:0007067; GO:0034184; GO:0045842; GO:0016925; GO:0000722 "PML body; SUMO ligase activity; Smc5-Smc6 complex; cell division; cellular senescence; chromosome, telomeric region; double-strand break repair via homologous recombination; metal ion binding; mitosis; positive regulation of maintenance of mitotic sister chromatid cohesion; positive regulation of mitotic metaphase/anaphase transition; protein sumoylation; telomere maintenance via recombination" IPR026846; IPR027370; IPR013083; Protein modification; protein sumoylation. E3 SUMO-protein ligase NSE2 (EC 6.3.2.-) (MMS21 homolog) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog) nsmce2 mms21 Xenopus laevis (African clawed frog) TR31931_c0_g1_i2 Q32KY9 NSE2_BOVIN 1.00E-21 GO:0016605; GO:0019789; GO:0030915; GO:0051301; GO:0090398; GO:0000781; GO:0000724; GO:0007067; GO:0034184; GO:0045842; GO:0016925; GO:0000722; GO:0008270 "PML body; SUMO ligase activity; Smc5-Smc6 complex; cell division; cellular senescence; chromosome, telomeric region; double-strand break repair via homologous recombination; mitosis; positive regulation of maintenance of mitotic sister chromatid cohesion; positive regulation of mitotic metaphase/anaphase transition; protein sumoylation; telomere maintenance via recombination; zinc ion binding" IPR026846; IPR004181; IPR013083; Protein modification; protein sumoylation. E3 SUMO-protein ligase NSE2 (EC 6.3.2.-) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog) NSMCE2 MMS21 Bos taurus (Bovine) TR31931_c0_g1_i5 Q7ZXH2 NSE2_XENLA 5.00E-31 GO:0016605; GO:0019789; GO:0030915; GO:0051301; GO:0090398; GO:0000781; GO:0000724; GO:0046872; GO:0007067; GO:0034184; GO:0045842; GO:0016925; GO:0000722 "PML body; SUMO ligase activity; Smc5-Smc6 complex; cell division; cellular senescence; chromosome, telomeric region; double-strand break repair via homologous recombination; metal ion binding; mitosis; positive regulation of maintenance of mitotic sister chromatid cohesion; positive regulation of mitotic metaphase/anaphase transition; protein sumoylation; telomere maintenance via recombination" IPR026846; IPR027370; IPR013083; Protein modification; protein sumoylation. E3 SUMO-protein ligase NSE2 (EC 6.3.2.-) (MMS21 homolog) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog) nsmce2 mms21 Xenopus laevis (African clawed frog) TR31932_c0_g1_i1 Q9D0R2 SYTC_MOUSE 0 GO:0005524; GO:0005737; GO:0004829; GO:0006435 ATP binding; cytoplasm; threonine-tRNA ligase activity; threonyl-tRNA aminoacylation IPR002314; IPR006195; IPR004154; IPR012675; IPR004095; IPR012676; IPR002320; IPR018163; IPR012947; "Threonine--tRNA ligase, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS)" Tars Mus musculus (Mouse) TR31932_c0_g1_i2 A6QNM8 SYTC2_BOVIN 0 GO:0005524; GO:0005737; GO:0004829; GO:0006435 ATP binding; cytoplasm; threonine-tRNA ligase activity; threonyl-tRNA aminoacylation IPR002314; IPR006195; IPR004154; IPR012675; IPR004095; IPR012676; IPR002320; IPR018163; IPR012947; "Probable threonine--tRNA ligase 2, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase-like protein 2)" TARSL2 Bos taurus (Bovine) TR31932_c0_g1_i3 Q47Z50 SYP_COLP3 8.00E-06 GO:0005524; GO:0002161; GO:0005737; GO:0004827; GO:0006433; GO:0006450 ATP binding; aminoacyl-tRNA editing activity; cytoplasm; proline-tRNA ligase activity; prolyl-tRNA aminoacylation; regulation of translational fidelity IPR002314; IPR006195; IPR004154; IPR002316; IPR004500; IPR023717; IPR007214; Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS) proS CPS_3230 Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) TR31932_c0_g1_i4 Q9D0R2 SYTC_MOUSE 0 GO:0005524; GO:0005737; GO:0004829; GO:0006435 ATP binding; cytoplasm; threonine-tRNA ligase activity; threonyl-tRNA aminoacylation IPR002314; IPR006195; IPR004154; IPR012675; IPR004095; IPR012676; IPR002320; IPR018163; IPR012947; "Threonine--tRNA ligase, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS)" Tars Mus musculus (Mouse) TR31933_c0_g1_i1 Q19673 TYR3_CAEEL 4.00E-58 GO:0046872; GO:0004497 metal ion binding; monooxygenase activity IPR003582; IPR002227; IPR008922; Putative tyrosinase-like protein tyr-3 tyr-3 F21C3.2 Caenorhabditis elegans TR31935_c6_g1_i1 Q9W3W5 WIF1_DROME 2.00E-64 GO:0045880; GO:0050821; GO:0005578; GO:0007224; GO:0008039 positive regulation of smoothened signaling pathway; protein stabilization; proteinaceous extracellular matrix; smoothened signaling pathway; synaptic target recognition IPR000742; IPR013032; IPR003306; Protein shifted (WIF-1-like protein) shf CG3135 Drosophila melanogaster (Fruit fly) TR31936_c0_g3_i1 Q15382 RHEB_HUMAN 1.00E-72 GO:0019003; GO:0005525; GO:0003924; GO:0007050; GO:0005829; GO:0030425; GO:0008286; GO:0016020; GO:0046872; GO:0043025; GO:0005886; GO:0032008; GO:0007264; GO:0005681 O43924 GDP binding; GTP binding; GTPase activity; cell cycle arrest; cytosol; dendrite; insulin receptor signaling pathway; membrane; metal ion binding; neuronal cell body; plasma membrane; positive regulation of TOR signaling cascade; small GTPase mediated signal transduction; spliceosomal complex IPR027417; IPR005225; IPR001806; IPR020849; GTP-binding protein Rheb (Ras homolog enriched in brain) RHEB RHEB2 Homo sapiens (Human) TR31938_c3_g1_i1 A8Y5T1 CA194_DANRE 1.00E-36 IPR022179; Uncharacterized protein C1orf194 homolog si:ch211-163l21.7 Danio rerio (Zebrafish) (Brachydanio rerio) TR31940_c4_g2_i1 Q9CX98 CP2U1_MOUSE 3.00E-45 GO:0070330; GO:0005789; GO:0020037; GO:0016021; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding IPR001128; IPR017972; IPR002401; IPR008069; Cytochrome P450 2U1 (EC 1.14.14.1) Cyp2u1 Mus musculus (Mouse) TR31940_c4_g2_i2 Q6VVW9 CP2R1_MOUSE 3.00E-40 GO:0047749; GO:0005789; GO:0020037; GO:0005506; GO:0030343 cholestanetriol 26-monooxygenase activity; endoplasmic reticulum membrane; heme binding; iron ion binding; vitamin D3 25-hydroxylase activity IPR001128; IPR017972; IPR002401; Vitamin D 25-hydroxylase (EC 1.14.13.15) (Cytochrome P450 2R1) Cyp2r1 Mus musculus (Mouse) TR31940_c4_g2_i4 Q9CX98 CP2U1_MOUSE 7.00E-45 GO:0070330; GO:0005789; GO:0020037; GO:0016021; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding IPR001128; IPR017972; IPR002401; IPR008069; Cytochrome P450 2U1 (EC 1.14.14.1) Cyp2u1 Mus musculus (Mouse) TR31940_c4_g2_i5 O57525 CP17A_RANDY 6.00E-41 GO:0047442; GO:0020037; GO:0005506; GO:0016020; GO:0004508; GO:0006694 17-alpha-hydroxyprogesterone aldolase activity; heme binding; iron ion binding; membrane; steroid 17-alpha-monooxygenase activity; steroid biosynthetic process IPR001128; IPR017972; IPR002401; Lipid metabolism; steroid biosynthesis. "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.99.9) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Rana dybowskii (Dybovsky's frog) (Korean brown frog) TR31940_c4_g2_i6 O73853 CP17A_ICTPU 3.00E-40 GO:0047442; GO:0020037; GO:0005506; GO:0016020; GO:0004508; GO:0006694 17-alpha-hydroxyprogesterone aldolase activity; heme binding; iron ion binding; membrane; steroid 17-alpha-monooxygenase activity; steroid biosynthetic process IPR001128; IPR017972; IPR002401; Lipid metabolism; steroid biosynthesis. "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.99.9) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" cyp17a1 cyp17 Ictalurus punctatus (Channel catfish) (Silurus punctatus) TR31940_c4_g2_i7 O46658 CP2DP_PIG 1.00E-40 GO:0047749; GO:0005789; GO:0020037; GO:0005506; GO:0016712 "cholestanetriol 26-monooxygenase activity; endoplasmic reticulum membrane; heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen" IPR001128; IPR017972; IPR002401; IPR008069; Vitamin D(3) 25-hydroxylase (EC 1.14.13.15) (CYPIID25) (Cytochrome P450 2D25) CYP2D25 Sus scrofa (Pig) TR31941_c0_g1_i1 Q9VR07 INE_DROME 1.00E-19 GO:0016021; GO:0005328; GO:0005034; GO:0042066; GO:0009881; GO:0005886; GO:0047484; GO:0019226 integral to membrane; neurotransmitter:sodium symporter activity; osmosensor activity; perineurial glial growth; photoreceptor activity; plasma membrane; regulation of response to osmotic stress; transmission of nerve impulse IPR000175; IPR002944; Sodium- and chloride-dependent GABA transporter ine (Protein inebriated) (Protein receptor oscillation A) ine rosA CG15444 Drosophila melanogaster (Fruit fly) TR31941_c0_g1_i2 Q9MZ34 SC6A6_BOVIN 2.00E-27 GO:0005887; GO:0005328; GO:0005369 integral to plasma membrane; neurotransmitter:sodium symporter activity; taurine:sodium symporter activity IPR000175; IPR002434; Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6) SLC6A6 Bos taurus (Bovine) TR31942_c4_g1_i1 Q502M6 ANR29_DANRE 8.00E-22 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) TR31942_c4_g1_i2 Q9BR61 ACBD6_HUMAN 5.00E-09 GO:0005737; GO:0000062; GO:0008289; GO:0005634 cytoplasm; fatty-acyl-CoA binding; lipid binding; nucleus IPR000582; IPR002110; IPR020683; IPR014352; Acyl-CoA-binding domain-containing protein 6 ACBD6 Homo sapiens (Human) TR31942_c4_g1_i3 Q6KAE5 XB32_ORYSJ 2.00E-08 GO:0016874; GO:0016567; GO:0008270 ligase activity; protein ubiquitination; zinc ion binding IPR002110; IPR020683; IPR001841; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase XBOS32 (EC 6.3.2.-) (Ankyrin repeat domain and RING finger-containing protein XBOS32) (XB3 protein homolog 2) XBOS32 Os02g0791200 LOC_Os02g54860 OJ1046_F07.26 OsJ_08676 Oryza sativa subsp. japonica (Rice) TR31942_c4_g2_i1 Q9J516 V219_FOWPN 2.00E-12 GO:0004190; GO:0006508 aspartic-type endopeptidase activity; proteolysis IPR002110; IPR020683; IPR001995; IPR018272; Putative ankyrin repeat protein FPV219 FPV219 Fowlpox virus (strain NVSL) (FPV) TR31942_c4_g2_i2 Q92625 ANS1A_HUMAN 2.00E-11 GO:0005737; GO:0048013; GO:0043005; GO:0016322; GO:0005634; GO:0006929 P00533; P04626 cytoplasm; ephrin receptor signaling pathway; neuron projection; neuron remodeling; nucleus; substrate-dependent cell migration IPR002110; IPR020683; IPR011993; IPR006020; IPR001660; IPR013761; IPR021129; Ankyrin repeat and SAM domain-containing protein 1A (Odin) ANKS1A ANKS1 KIAA0229 ODIN Homo sapiens (Human) TR31943_c0_g1_i1 Q05B18 SHQ1_XENTR 5.00E-130 GO:0005829; GO:0005654; GO:0022618 cytosol; nucleoplasm; ribonucleoprotein complex assembly IPR007052; IPR008978; IPR007009; Protein SHQ1 homolog shq1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31944_c0_g1_i1 Q9D8V0 HM13_MOUSE 2.00E-165 GO:0004190; GO:0009986; GO:0005783; GO:0071458; GO:0071556; GO:0033619; GO:0008233; GO:0005886; GO:0042803 aspartic-type endopeptidase activity; cell surface; endoplasmic reticulum; integral to cytosolic side of endoplasmic reticulum membrane; integral to lumenal side of endoplasmic reticulum membrane; membrane protein proteolysis; peptidase activity; plasma membrane; protein homodimerization activity IPR007369; IPR006639; Minor histocompatibility antigen H13 (EC 3.4.23.-) (Presenilin-like protein 3) (Signal peptide peptidase) Hm13 H13 Psl3 Mus musculus (Mouse) TR31945_c2_g1_i1 Q6X632 GPR75_MOUSE 5.00E-23 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR000276; IPR017452; Probable G-protein coupled receptor 75 Gpr75 Mus musculus (Mouse) TR31946_c0_g1_i1 Q9Y4Z0 LSM4_HUMAN 4.00E-55 GO:0003723; GO:0008380; GO:0005688; GO:0005829; GO:0043928; GO:0006397; GO:0005681 Q9UK45; O95777 RNA binding; RNA splicing; U6 snRNP; cytosol; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; mRNA processing; spliceosomal complex IPR027141; IPR010920; IPR001163; IPR006649; U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP) LSM4 Homo sapiens (Human) TR31946_c0_g2_i1 P43321 SMD3_YEAST 2.00E-11 GO:0005685; GO:0071004; GO:0046540; GO:0005682; GO:0000243; GO:0005737; GO:0003729; GO:0000398 "U1 snRNP; U2-type prespliceosome; U4/U6 x U5 tri-snRNP complex; U5 snRNP; commitment complex; cytoplasm; mRNA binding; mRNA splicing, via spliceosome" IPR027141; IPR010920; IPR001163; IPR006649; Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3) SMD3 YLR147C L9634.6 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR31947_c0_g1_i2 Q2JVA4 GLMU_SYNJA 6.00E-26 GO:0006048; GO:0003977; GO:0000902; GO:0005737; GO:0019134; GO:0009245; GO:0009103; GO:0000287; GO:0009252; GO:0008360 UDP-N-acetylglucosamine biosynthetic process; UDP-N-acetylglucosamine diphosphorylase activity; cell morphogenesis; cytoplasm; glucosamine-1-phosphate N-acetyltransferase activity; lipid A biosynthetic process; lipopolysaccharide biosynthetic process; magnesium ion binding; peptidoglycan biosynthetic process; regulation of cell shape IPR005882; IPR005175; IPR001451; IPR025877; IPR011004; Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2. Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1. Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)] glmU CYA_1151 Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime) TR31947_c1_g2_i1 Q09329 MLO2_SCHPO 2.00E-23 GO:0005829; GO:0000070; GO:0005634; GO:0016567; GO:0004842; GO:0008270 cytosol; mitotic sister chromatid segregation; nucleus; protein ubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR019786; IPR011011; IPR003126; IPR013993; IPR001965; IPR019787; IPR013083; Protein mlo2 mlo2 SPBC4.05 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR31947_c1_g3_i2 Q8N806 UBR7_HUMAN 3.00E-58 GO:0004842; GO:0008270 ubiquitin-protein ligase activity; zinc ion binding IPR011011; IPR003126; IPR001965; IPR013083; Protein modification; protein ubiquitination. Putative E3 ubiquitin-protein ligase UBR7 (EC 6.3.2.-) (N-recognin-7) UBR7 C14orf130 Homo sapiens (Human) TR31948_c7_g2_i2 Q7TPD2 F185A_MOUSE 9.00E-36 IPR025386; Protein FAM185A Fam185a Mus musculus (Mouse) TR31950_c0_g2_i1 Q9V9Z1 RM32_DROME 1.00E-22 GO:0005762; GO:0003735; GO:0006412 mitochondrial large ribosomal subunit; structural constituent of ribosome; translation IPR011332; "39S ribosomal protein L32, mitochondrial (L32mt) (MRP-L32)" mRpL32 CG12220 Drosophila melanogaster (Fruit fly) TR31951_c0_g1_i1 Q80Y75 DJB13_MOUSE 2.00E-145 GO:0006457 protein folding IPR002939; IPR001623; IPR018253; IPR008971; DnaJ homolog subfamily B member 13 (Testis and spermatogenesis cell-related protein 6) (Testis spermatocyte apoptosis-related gene 6 protein) (Testis spermatogenesis apoptosis-related gene 3 protein) (Testis spermatogenesis apoptosis-related gene 6 protein) Dnajb13 Tsarg Tsarg3 Tsarg6 Mus musculus (Mouse) TR31953_c0_g1_i1 B5DEQ3 XPP3_RAT 5.00E-140 GO:0004177; GO:0009987; GO:0030145; GO:0005739 aminopeptidase activity; cellular process; manganese ion binding; mitochondrion IPR007865; IPR000994; Probable Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3) (EC 3.4.11.9) (Aminopeptidase P3) (APP3) Xpnpep3 Rattus norvegicus (Rat) TR31954_c0_g1_i1 Q9URX7 ANM1_SCHPO 1.00E-74 GO:0005829; GO:0006406; GO:0005634; GO:0019919; GO:0016274 "cytosol; mRNA export from nucleus; nucleus; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; protein-arginine N-methyltransferase activity" IPR025799; IPR025714; Probable protein arginine N-methyltransferase (EC 2.1.1.-) SPAC890.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR31958_c1_g1_i1 Q09YM8 CTTB2_RABIT 7.00E-22 GO:0005938; GO:0043197 cell cortex; dendritic spine IPR002110; IPR020683; IPR019131; Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Oryctolagus cuniculus (Rabbit) TR31958_c1_g1_i2 Q8N9V6 ANR53_HUMAN 1.00E-06 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 53 ANKRD53 Homo sapiens (Human) TR31958_c1_g1_i3 Q9FY48 KEG_ARATH 4.00E-09 GO:0005524; GO:0005794; GO:0009738; GO:0006952; GO:0048589; GO:0005769; GO:0016197; GO:0009788; GO:0004672; GO:0004674; GO:0032940; GO:0005802; GO:0004842; GO:0008270 Q9SJN0 ATP binding; Golgi apparatus; abscisic acid mediated signaling pathway; defense response; developmental growth; early endosome; endosomal transport; negative regulation of abscisic acid mediated signaling pathway; protein kinase activity; protein serine/threonine kinase activity; secretion by cell; trans-Golgi network; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR011009; IPR000719; IPR027370; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase KEG (EC 2.7.11.1) (EC 6.3.2.-) (Protein KEEP ON GOING) (RING finger protein KEG) KEG At5g13530 T6I14.60 T6I14.70 Arabidopsis thaliana (Mouse-ear cress) TR31958_c1_g1_i4 Q54HW1 PSD10_DICDI 2.00E-21 IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) psmD10 DDB_G0289189 Dictyostelium discoideum (Slime mold) TR31958_c1_g1_i5 F8W2M1 HACE1_DANRE 1.00E-24 GO:0032580; GO:0000139; GO:0007030; GO:0017137; GO:0007049; GO:0005783; GO:0061025; GO:0070936; GO:0042787; GO:0030334; GO:0004842 Golgi cisterna membrane; Golgi membrane; Golgi organization; Rab GTPase binding; cell cycle; endoplasmic reticulum; membrane fusion; protein K48-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of cell migration; ubiquitin-protein ligase activity IPR002110; IPR020683; IPR000569; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HACE1 (EC 6.3.2.-) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) hace1 Danio rerio (Zebrafish) (Brachydanio rerio) TR31958_c1_g1_i8 P16157 ANK1_HUMAN 6.00E-35 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR31958_c1_g1_i9 Q5UQI7 YR838_MIMIV 1.00E-06 IPR002110; IPR020683; Putative ankyrin repeat protein R838 MIMI_R838 Acanthamoeba polyphaga mimivirus (APMV) TR31958_c1_g2_i1 Q9NU02 ANKR5_HUMAN 7.00E-14 GO:0005509 calcium ion binding IPR002110; IPR020683; IPR011992; IPR002048; Ankyrin repeat and EF-hand domain-containing protein 1 (Ankyrin repeat domain-containing protein 5) ANKEF1 ANKRD5 Homo sapiens (Human) TR31959_c0_g1_i1 P19483 ATPA_BOVIN 0 GO:0005524; GO:0015991; GO:0015986; GO:0005753; GO:0005886; GO:0046933; GO:0045261; GO:0046961 "ATP binding; ATP hydrolysis coupled proton transport; ATP synthesis coupled proton transport; mitochondrial proton-transporting ATP synthase complex; plasma membrane; proton-transporting ATP synthase activity, rotational mechanism; proton-transporting ATP synthase complex, catalytic core F(1); proton-transporting ATPase activity, rotational mechanism" IPR020003; IPR023366; IPR005294; IPR000793; IPR000194; IPR004100; IPR027417; "ATP synthase subunit alpha, mitochondrial" ATP5A1 ATP5A2 Bos taurus (Bovine) TR31960_c1_g1_i3 Q7ZUB3 TSN31_DANRE 5.00E-43 GO:0016021 integral to membrane IPR000301; IPR018499; Tetraspanin-31 (Tspan-31) (Sarcoma-amplified sequence homolog) tspan31 sas zgc:56710 Danio rerio (Zebrafish) (Brachydanio rerio) TR31963_c5_g1_i1 Q9JM00 VAX1_RAT 3.00E-47 GO:0007411; GO:0007420; GO:0043010; GO:0031490; GO:0007406; GO:0000122; GO:0001764; GO:0005634; GO:0060021; GO:0003700; GO:0035914; GO:0000976; GO:0006351 "axon guidance; brain development; camera-type eye development; chromatin DNA binding; negative regulation of neuroblast proliferation; negative regulation of transcription from RNA polymerase II promoter; neuron migration; nucleus; palate development; sequence-specific DNA binding transcription factor activity; skeletal muscle cell differentiation; transcription regulatory region sequence-specific DNA binding; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; IPR000047; Ventral anterior homeobox 1 Vax1 Rattus norvegicus (Rat) TR31963_c5_g1_i4 Q9IAX9 VAX2B_XENLA 2.00E-46 GO:0016055; GO:0007275; GO:0005634; GO:0003700; GO:0000976; GO:0006351 "Wnt receptor signaling pathway; multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity; transcription regulatory region sequence-specific DNA binding; transcription, DNA-dependent" IPR017970; IPR001356; IPR020479; IPR009057; IPR000047; Ventral anterior homeobox 2b (Ventral anterior homeobox 3) vax2-b vax3 Xenopus laevis (African clawed frog) TR31964_c1_g2_i1 Q24K22 HGFL_BOVIN 2.00E-09 GO:0005576; GO:0006508; GO:0004252 extracellular region; proteolysis; serine-type endopeptidase activity IPR024174; IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR001254; IPR001314; IPR009003; Hepatocyte growth factor-like protein (Macrophage stimulatory protein) (Macrophage-stimulating protein) (MSP) [Cleaved into: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain] MST1 HGFL Bos taurus (Bovine) TR31964_c2_g2_i1 P20918 PLMN_MOUSE 1.00E-07 GO:0007596; GO:0022617; GO:0005615; GO:0031232; GO:0019897; GO:0042730; GO:0043231; GO:0060716; GO:0071674; GO:0046716; GO:0045445; GO:0016525; GO:0010812; GO:0051918; GO:0051919; GO:0051603; GO:0004252; GO:0042246; GO:0048771; GO:0060707 blood coagulation; extracellular matrix disassembly; extracellular space; extrinsic to external side of plasma membrane; extrinsic to plasma membrane; fibrinolysis; intracellular membrane-bounded organelle; labyrinthine layer blood vessel development; mononuclear cell migration; muscle cell cellular homeostasis; myoblast differentiation; negative regulation of angiogenesis; negative regulation of cell-substrate adhesion; negative regulation of fibrinolysis; positive regulation of fibrinolysis; proteolysis involved in cellular protein catabolic process; serine-type endopeptidase activity; tissue regeneration; tissue remodeling; trophoblast giant cell differentiation IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]" Plg Mus musculus (Mouse) TR31964_c2_g2_i4 P16109 LYAM3_HUMAN 2.00E-24 GO:0050829; GO:0009897; GO:0005615; GO:0042806; GO:0043208; GO:0008201; GO:0007157; GO:0006954; GO:0005887; GO:0007159; GO:0050900; GO:0050901; GO:0001530; GO:0005634; GO:0070492; GO:0030168; GO:0031092; GO:0002576; GO:0031088; GO:0002687; GO:0014068; GO:0010572; GO:0033623; GO:0032496; GO:0033691 defense response to Gram-negative bacterium; external side of plasma membrane; extracellular space; fucose binding; glycosphingolipid binding; heparin binding; heterophilic cell-cell adhesion; inflammatory response; integral to plasma membrane; leukocyte cell-cell adhesion; leukocyte migration; leukocyte tethering or rolling; lipopolysaccharide binding; nucleus; oligosaccharide binding; platelet activation; platelet alpha granule membrane; platelet degranulation; platelet dense granule membrane; positive regulation of leukocyte migration; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of platelet activation; regulation of integrin activation; response to lipopolysaccharide; sialic acid binding IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR002396; IPR000436; P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P) SELP GMRP GRMP Homo sapiens (Human) TR31964_c2_g2_i5 Q95237 LYAM1_PANTR 8.00E-09 GO:0030246; GO:0007155; GO:0009897; GO:0016021; GO:0033198 carbohydrate binding; cell adhesion; external side of plasma membrane; integral to membrane; response to ATP IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR016348; IPR002396; IPR000436; L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (CD antigen CD62L) SELL Pan troglodytes (Chimpanzee) TR31964_c2_g2_i7 P20918 PLMN_MOUSE 1.00E-11 GO:0007596; GO:0022617; GO:0005615; GO:0031232; GO:0019897; GO:0042730; GO:0043231; GO:0060716; GO:0071674; GO:0046716; GO:0045445; GO:0016525; GO:0010812; GO:0051918; GO:0051919; GO:0051603; GO:0004252; GO:0042246; GO:0048771; GO:0060707 blood coagulation; extracellular matrix disassembly; extracellular space; extrinsic to external side of plasma membrane; extrinsic to plasma membrane; fibrinolysis; intracellular membrane-bounded organelle; labyrinthine layer blood vessel development; mononuclear cell migration; muscle cell cellular homeostasis; myoblast differentiation; negative regulation of angiogenesis; negative regulation of cell-substrate adhesion; negative regulation of fibrinolysis; positive regulation of fibrinolysis; proteolysis involved in cellular protein catabolic process; serine-type endopeptidase activity; tissue regeneration; tissue remodeling; trophoblast giant cell differentiation IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]" Plg Mus musculus (Mouse) TR31964_c3_g1_i1 O14522 PTPRT_HUMAN 2.00E-43 GO:0045294; GO:0009986; GO:0045295; GO:0007156; GO:0016021; GO:0005886; GO:0004725; GO:0016790; GO:0007169 P62993; Q99K10; Q69ZK9; Q9CS84; Q6P9K9; Q16849 alpha-catenin binding; cell surface; gamma-catenin binding; homophilic cell adhesion; integral to membrane; plasma membrane; protein tyrosine phosphatase activity; thiolester hydrolase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) TR31964_c3_g1_i2 Q9W6V5 PTPRJ_CHICK 2.00E-40 GO:0005911; GO:0016021; GO:0043407; GO:0050860; GO:0042059; GO:0051898; GO:0035335; GO:0016791; GO:0005886; GO:0048008; GO:0051894; GO:0004725; GO:0032587 cell-cell junction; integral to membrane; negative regulation of MAP kinase activity; negative regulation of T cell receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein kinase B signaling cascade; peptidyl-tyrosine dephosphorylation; phosphatase activity; plasma membrane; platelet-derived growth factor receptor signaling pathway; positive regulation of focal adhesion assembly; protein tyrosine phosphatase activity; ruffle membrane IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (Supporting-cell antigen) PTPRJ Gallus gallus (Chicken) TR31964_c3_g1_i4 P28203 PTP11_STYPL 1.00E-16 GO:0035335; GO:0004725 peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR000242; Tyrosine-protein phosphatase 11 (EC 3.1.3.48) (Fragment) STY-11 Styela plicata (Sea squirt) (Ascidia plicata) TR31964_c3_g2_i1 P28209 PTP17_STYPL 4.00E-20 GO:0035335; GO:0004725 peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR000242; Tyrosine-protein phosphatase 17 (EC 3.1.3.48) (Fragment) STY-17 Styela plicata (Sea squirt) (Ascidia plicata) TR31964_c5_g1_i1 O18783 PLMN_MACEU 1.00E-13 GO:0007596; GO:0005576; GO:0042730; GO:0006508; GO:0004252; GO:0048771 blood coagulation; extracellular region; fibrinolysis; proteolysis; serine-type endopeptidase activity; tissue remodeling IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Macropus eugenii (Tammar wallaby) TR31965_c1_g1_i2 Q8CIG9 FBXL8_MOUSE 7.00E-37 IPR001810; F-box/LRR-repeat protein 8 (F-box and leucine-rich repeat protein 8) (F-box protein FBL8) Fbxl8 Fbl8 Mus musculus (Mouse) TR31966_c0_g1_i2 P56286 IF2A_SCHPO 1.00E-30 GO:0002183; GO:0005829; GO:0005850; GO:0007093; GO:0005634; GO:0043561; GO:0035617; GO:0003743 cytoplasmic translational initiation; cytosol; eukaryotic translation initiation factor 2 complex; mitotic cell cycle checkpoint; nucleus; regulation of translational initiation in response to osmotic stress; stress granule disassembly; translation initiation factor activity IPR012340; IPR003029; IPR022967; IPR024055; IPR024054; IPR011488; Eukaryotic translation initiation factor 2 subunit alpha (eIF-2-alpha) tif211 SPAC3G9.09c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR31966_c0_g1_i3 P20459 IF2A_YEAST 2.00E-23 GO:0005850; GO:0043614; GO:0005840; GO:0003743 eukaryotic translation initiation factor 2 complex; multi-eIF complex; ribosome; translation initiation factor activity IPR012340; IPR003029; IPR022967; IPR024055; IPR024054; IPR011488; Eukaryotic translation initiation factor 2 subunit alpha (eIF-2-alpha) SUI2 TIF211 YJR007W J1429 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR31966_c0_g4_i1 P20460 IF2A_PIG 6.00E-22 GO:0010494; GO:0006417; GO:0003743 cytoplasmic stress granule; regulation of translation; translation initiation factor activity IPR012340; IPR003029; IPR022967; Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (Fragment) EIF2S1 EIF2A Sus scrofa (Pig) TR31966_c0_g5_i1 Q6GL89 IF2A_XENTR 4.00E-56 GO:0005850; GO:0006417; GO:0003743 eukaryotic translation initiation factor 2 complex; regulation of translation; translation initiation factor activity IPR012340; IPR003029; IPR022967; IPR024055; IPR024054; IPR011488; Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) eif2s1 eif2a TGas059e16.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31967_c0_g2_i2 Q80U28 MADD_MOUSE 9.00E-165 GO:0017112; GO:0000187; GO:0005737; GO:0097194; GO:0016021; GO:2001234; GO:0051726 Rab guanyl-nucleotide exchange factor activity; activation of MAPK activity; cytoplasm; execution phase of apoptosis; integral to membrane; negative regulation of apoptotic signaling pathway; regulation of cell cycle IPR005112; IPR001194; IPR005113; MAP kinase-activating death domain protein (Rab3 GDP/GTP exchange factor) Madd Kiaa0358 Mus musculus (Mouse) TR31967_c0_g2_i3 O08873 MADD_RAT 0 GO:0017112; GO:0000187; GO:0005737; GO:0097194; GO:0016021; GO:0005886; GO:0051726; GO:1902041 Rab guanyl-nucleotide exchange factor activity; activation of MAPK activity; cytoplasm; execution phase of apoptosis; integral to membrane; plasma membrane; regulation of cell cycle; regulation of extrinsic apoptotic signaling pathway via death domain receptors IPR005112; IPR001194; IPR005113; MAP kinase-activating death domain protein (Rab3 GDP/GTP exchange factor) Madd Rattus norvegicus (Rat) TR31967_c0_g2_i5 Q9VXY2 MADD_DROME 2.00E-153 GO:0017112; GO:0000187; GO:0006915; GO:0016021; GO:0007269; GO:0051726; GO:1902041; GO:0008021; GO:0016192 Rab guanyl-nucleotide exchange factor activity; activation of MAPK activity; apoptotic process; integral to membrane; neurotransmitter secretion; regulation of cell cycle; regulation of extrinsic apoptotic signaling pathway via death domain receptors; synaptic vesicle; vesicle-mediated transport IPR005112; IPR001194; IPR005113; MAP kinase-activating death domain protein (Rab3 guanyl-nucleotide exchange factor) rab3-GEF CG5627 Drosophila melanogaster (Fruit fly) TR31968_c2_g1_i1 Q26636 CATL_SARPE 8.00E-121 GO:0030154; GO:0008234; GO:0005764; GO:0007275; GO:0006508 cell differentiation; cysteine-type peptidase activity; lysosome; multicellular organismal development; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) TR31968_c2_g1_i2 Q05094 CYSP2_LEIPI 6.00E-49 GO:0004197; GO:0005764; GO:0009405; GO:0006508 cysteine-type endopeptidase activity; lysosome; pathogenesis; proteolysis IPR021981; IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cysteine proteinase 2 (EC 3.4.22.-) (Amastigote cysteine proteinase A-2) CYS2 Leishmania pifanoi TR31969_c5_g1_i2 Q6P9Z4 FEM1A_DANRE 9.00E-08 GO:0005737; GO:0051438; GO:0004842 cytoplasm; regulation of ubiquitin-protein ligase activity; ubiquitin-protein ligase activity IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog A (FEM1a) (FEM1-alpha) fem1a zgc:63483 Danio rerio (Zebrafish) (Brachydanio rerio) TR31970_c0_g1_i1 Q80X08 FAM21_RAT 3.00E-12 GO:0071203; GO:0005769; GO:0031901; GO:0042147 "WASH complex; early endosome; early endosome membrane; retrograde transport, endosome to Golgi" IPR027308; WASH complex subunit FAM21 Fam21 Rattus norvegicus (Rat) TR31970_c0_g4_i1 Q6PGL7 FAM21_MOUSE 1.00E-52 GO:0071203; GO:0005769; GO:0031901; GO:0042147 "WASH complex; early endosome; early endosome membrane; retrograde transport, endosome to Golgi" IPR027308; WASH complex subunit FAM21 Fam21 D6Wsu116e Kiaa0592 Mus musculus (Mouse) TR31972_c1_g1_i1 Q9P2E3 ZNFX1_HUMAN 4.00E-37 GO:0046872 metal ion binding IPR016024; IPR027417; NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) TR31973_c0_g2_i1 Q0VA16 WDR70_XENTR 0 IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 70 wdr70 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR31974_c5_g3_i3 Q99946 PRRT1_HUMAN 2.00E-07 GO:0030054; GO:0016021; GO:0005886; GO:0009607; GO:0045202 cell junction; integral to membrane; plasma membrane; response to biotic stimulus; synapse IPR007593; Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) PRRT1 C6orf31 NG5 Homo sapiens (Human) TR31975_c0_g1_i2 Q20681 BAT38_CAEEL 2.00E-08 IPR000210; IPR011333; IPR013069; IPR002083; IPR008974; BTB and MATH domain-containing protein 38 bath-38 F52H3.3 Caenorhabditis elegans TR31976_c0_g2_i2 Q86WV6 TM173_HUMAN 4.00E-10 GO:0005794; GO:0002218; GO:0006915; GO:0071360; GO:0035458; GO:0061507; GO:0035438; GO:0030659; GO:0051607; GO:0005789; GO:0045087; GO:0016021; GO:0032608; GO:0005741; GO:0048471; GO:0005777; GO:0005886; GO:0002230; GO:0032092; GO:0033160; GO:0042993; GO:0045944; GO:0032481; GO:0042803; GO:0019901; GO:0008134 Itself; P27958; Q99IB8; Q96A33; P39656; Q16666; P51617; O94822; Q7Z434; Q96N66; O95470; P42226; P46977; O15260; Q9UHD2 "Golgi apparatus; activation of innate immune response; apoptotic process; cellular response to exogenous dsRNA; cellular response to interferon-beta; cyclic-GMP-AMP binding; cyclic-di-GMP binding; cytoplasmic vesicle membrane; defense response to virus; endoplasmic reticulum membrane; innate immune response; integral to membrane; interferon-beta production; mitochondrial outer membrane; perinuclear region of cytoplasm; peroxisome; plasma membrane; positive regulation of defense response to virus by host; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of type I interferon production; protein homodimerization activity; protein kinase binding; transcription factor binding" Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173) TMEM173 ERIS MITA STING Homo sapiens (Human) TR31981_c2_g1_i2 Q9WY68 1A1D_THEMA 7.00E-44 GO:0008660; GO:0008152 1-aminocyclopropane-1-carboxylate deaminase activity; metabolic process IPR027278; IPR005966; IPR001926; Putative 1-aminocyclopropane-1-carboxylate deaminase (ACC deaminase) (EC 3.5.99.7) TM_0225 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR31981_c2_g1_i4 O57809 1A1D_PYRHO 7.00E-40 GO:0008660; GO:0008152 1-aminocyclopropane-1-carboxylate deaminase activity; metabolic process IPR027278; IPR005966; IPR001926; Putative 1-aminocyclopropane-1-carboxylate deaminase (ACC deaminase) (EC 3.5.99.7) PH0054 PHBE027 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) TR31981_c2_g1_i7 Q9WY68 1A1D_THEMA 1.00E-42 GO:0008660; GO:0008152 1-aminocyclopropane-1-carboxylate deaminase activity; metabolic process IPR027278; IPR005966; IPR001926; Putative 1-aminocyclopropane-1-carboxylate deaminase (ACC deaminase) (EC 3.5.99.7) TM_0225 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR31983_c0_g1_i1 Q568W0 SELW_DANRE 9.00E-27 GO:0016209; GO:0045454; GO:0005737; GO:0008430 antioxidant activity; cell redox homeostasis; cytoplasm; selenium binding IPR011893; IPR012336; Selenoprotein W (SelW) sepw1 Danio rerio (Zebrafish) (Brachydanio rerio) TR31984_c0_g1_i1 Q9H300 PARL_HUMAN 9.00E-75 GO:0016021; GO:0005743; GO:0005739; GO:2001243; GO:0090201; GO:0005634; GO:0006508; GO:0004252 integral to membrane; mitochondrial inner membrane; mitochondrion; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of release of cytochrome c from mitochondria; nucleus; proteolysis; serine-type endopeptidase activity IPR002610; IPR022764; "Presenilins-associated rhomboid-like protein, mitochondrial (EC 3.4.21.105) (Mitochondrial intramembrane cleaving protease PARL) [Cleaved into: P-beta (Pbeta)]" PARL PSARL PRO2207 Homo sapiens (Human) TR31985_c4_g1_i1 Q9DAM9 FANK1_MOUSE 7.00E-10 GO:0005737; GO:0005634 cytoplasm; nucleus IPR002110; IPR020683; IPR003961; IPR013783; Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell-specific gene 1 protein) (GSG1) Fank1 Mus musculus (Mouse) TR31985_c4_g2_i1 Q99549 MPP8_HUMAN 7.00E-31 GO:0007049; GO:0005737; GO:0035064; GO:0045892; GO:0005720; GO:0000788; GO:0005730; GO:0005886; GO:0044030; GO:0006351 Q9H9B1; P68431; Q15047 "cell cycle; cytoplasm; methylated histone residue binding; negative regulation of transcription, DNA-dependent; nuclear heterochromatin; nuclear nucleosome; nucleolus; plasma membrane; regulation of DNA methylation; transcription, DNA-dependent" IPR002110; IPR020683; IPR023780; IPR000953; IPR016197; IPR023779; M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) MPHOSPH8 MPP8 Homo sapiens (Human) TR31987_c0_g1_i1 Q9D0L6 BAMBI_MOUSE 2.00E-23 GO:0016477; GO:0005737; GO:0016021; GO:0016020; GO:0030512; GO:0005886; GO:0090263; GO:0035413; GO:0008284; GO:0010718; GO:0032092; GO:0045893; GO:0008360; GO:0007179 "cell migration; cytoplasm; integral to membrane; membrane; negative regulation of transforming growth factor beta receptor signaling pathway; plasma membrane; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of catenin import into nucleus; positive regulation of cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of protein binding; positive regulation of transcription, DNA-dependent; regulation of cell shape; transforming growth factor beta receptor signaling pathway" IPR009345; BMP and activin membrane-bound inhibitor homolog (Putative transmembrane protein NMA) Bambi Nma Mus musculus (Mouse) TR31988_c0_g1_i1 P0CE10 Y4102_ARATH 1.00E-51 GO:0005524; GO:0008026; GO:0003723; GO:0009507; GO:0008270 ATP binding; ATP-dependent helicase activity; RNA binding; chloroplast; zinc ion binding IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR004087; IPR027417; IPR007087; IPR015880; IPR018957; IPR002867; IPR001841; IPR013083; IPR017907; "Putative uncharacterized protein At4g01020, chloroplastic" At4g01020 F3I3.40 Arabidopsis thaliana (Mouse-ear cress) TR31988_c2_g1_i1 A2A4P0 DHX8_MOUSE 3.00E-19 GO:0005524; GO:0008026; GO:0003723; GO:0008380; GO:0071013; GO:0006397 ATP binding; ATP-dependent helicase activity; RNA binding; RNA splicing; catalytic step 2 spliceosome; mRNA processing IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR012340; IPR027417; IPR003029; IPR022967; ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) Dhx8 Mus musculus (Mouse) TR31988_c6_g2_i1 P0CE10 Y4102_ARATH 2.00E-17 GO:0005524; GO:0008026; GO:0003723; GO:0009507; GO:0008270 ATP binding; ATP-dependent helicase activity; RNA binding; chloroplast; zinc ion binding IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR004087; IPR027417; IPR007087; IPR015880; IPR018957; IPR002867; IPR001841; IPR013083; IPR017907; "Putative uncharacterized protein At4g01020, chloroplastic" At4g01020 F3I3.40 Arabidopsis thaliana (Mouse-ear cress) TR31989_c0_g1_i2 P83425 HIP_MYTED 4.00E-14 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR31989_c0_g1_i3 P63182 CBLN1_RAT 3.00E-08 GO:0030054; GO:0005576; GO:0051965; GO:0045211; GO:0009306 cell junction; extracellular region; positive regulation of synapse assembly; postsynaptic membrane; protein secretion IPR001073; IPR008983; Cerebellin-1 (Precerebellin) [Cleaved into: Cerebellin (CER); [des-Ser1]-cerebellin (des-Ser(1)-cerebellin) ([des-Ser1]CER) (des-CER) (des-Ser1CER)] Cbln1 Rattus norvegicus (Rat) TR31992_c2_g1_i2 P28651 CAH8_MOUSE 5.00E-89 GO:0004089; GO:0005737; GO:0006730; GO:0048015; GO:0008270 carbonate dehydratase activity; cytoplasm; one-carbon metabolic process; phosphatidylinositol-mediated signaling; zinc ion binding IPR001148; IPR023561; IPR018338; IPR018434; Carbonic anhydrase-related protein (CARP) (Carbonic anhydrase VIII) (CA-VIII) Ca8 Cals Cals1 Car8 Carp Mus musculus (Mouse) TR31993_c3_g2_i2 Q9P203 BTBD7_HUMAN 0 IPR011705; IPR000210; IPR011333; IPR013069; BTB/POZ domain-containing protein 7 BTBD7 KIAA1525 Homo sapiens (Human) TR31995_c8_g1_i1 P42225 STAT1_MOUSE 1.00E-25 GO:0003677; GO:0006919; GO:0030424; GO:0008015; GO:0005509; GO:0005829; GO:0030425; GO:0060333; GO:0031663; GO:0072162; GO:0072136; GO:0034240; GO:0003340; GO:0072308; GO:0000122; GO:0005634; GO:0002053; GO:0048661; GO:0061326; GO:0051591; GO:0043330; GO:0043434; GO:0003700; GO:0004871; GO:0006351; GO:0060337 P42228; Q61069; Q64705 "DNA binding; activation of cysteine-type endopeptidase activity involved in apoptotic process; axon; blood circulation; calcium ion binding; cytosol; dendrite; interferon-gamma-mediated signaling pathway; lipopolysaccharide-mediated signaling pathway; metanephric mesenchymal cell differentiation; metanephric mesenchymal cell proliferation involved in metanephros development; negative regulation of macrophage fusion; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of metanephric nephron tubule epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of mesenchymal cell proliferation; positive regulation of smooth muscle cell proliferation; renal tubule development; response to cAMP; response to exogenous dsRNA; response to peptide hormone stimulus; sequence-specific DNA binding transcription factor activity; signal transducer activity; transcription, DNA-dependent; type I interferon-mediated signaling pathway" IPR011992; IPR008967; IPR000980; IPR001217; IPR022752; IPR013800; IPR015988; IPR013801; IPR012345; IPR013799; Signal transducer and activator of transcription 1 Stat1 Mus musculus (Mouse) TR31998_c0_g1_i2 B5X5D0 CI116_SALSA 7.00E-28 IPR026507; UPF0691 protein C9orf116 homolog Salmo salar (Atlantic salmon) TR32000_c1_g2_i1 Q9P2G9 KLHL8_HUMAN 0 GO:0031463; GO:0042787 Cul3-RING ubiquitin ligase complex; protein ubiquitination involved in ubiquitin-dependent protein catabolic process IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 8 KLHL8 KIAA1378 Homo sapiens (Human) TR32001_c1_g1_i2 P23438 SSRB_CANFA 4.00E-73 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR008856; Translocon-associated protein subunit beta (TRAP-beta) (Glycoprotein 25H) (gp25H) (Signal sequence receptor subunit beta) (SSR-beta) SSR2 Canis familiaris (Dog) (Canis lupus familiaris) TR32003_c0_g1_i1 Q4KML2 CRYD_DANRE 0 GO:0003913; GO:0006281; GO:0018298 DNA photolyase activity; DNA repair; protein-chromophore linkage IPR002081; IPR014133; IPR006050; IPR005101; IPR014729; Cryptochrome DASH (Protein CRY-DASH) (zCRY-DASH) cry-dash Danio rerio (Zebrafish) (Brachydanio rerio) TR32003_c0_g1_i2 Q75WS4 CRYD_XENLA 0 GO:0003913; GO:0006281; GO:0018298 DNA photolyase activity; DNA repair; protein-chromophore linkage IPR002081; IPR014133; IPR006050; IPR005101; IPR014729; Cryptochrome DASH cry-dash Xenopus laevis (African clawed frog) TR32005_c1_g1_i1 Q9P324 YI78_SCHPO 2.00E-20 GO:0005829; GO:0005634; GO:0016491 cytosol; nucleus; oxidoreductase activity IPR002198; IPR002347; IPR016040; Uncharacterized oxidoreductase C977.08/C1348.09 (EC 1.-.-.-) SPAC977.08; SPAC1348.09 SPBC1348.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR32005_c1_g1_i2 Q3T0R4 DRS7B_BOVIN 1.00E-89 GO:0016021; GO:0016491; GO:0005778 integral to membrane; oxidoreductase activity; peroxisomal membrane IPR002198; IPR002347; IPR016040; IPR020904; Dehydrogenase/reductase SDR family member 7B (EC 1.1.-.-) DHRS7B Bos taurus (Bovine) TR32006_c1_g1_i5 P29349 CSW_DROME 2.00E-06 GO:0005737; GO:0008069; GO:0007173; GO:0007427; GO:0008543; GO:0007444; GO:0007498; GO:0000278; GO:0043066; GO:0004726; GO:0007428; GO:0004728; GO:0045314; GO:0045500; GO:0007362; GO:0008293; GO:0007418 "cytoplasm; dorsal/ventral axis specification, ovarian follicular epithelium; epidermal growth factor receptor signaling pathway; epithelial cell migration, open tracheal system; fibroblast growth factor receptor signaling pathway; imaginal disc development; mesoderm development; mitotic cell cycle; negative regulation of apoptotic process; non-membrane spanning protein tyrosine phosphatase activity; primary branching, open tracheal system; receptor signaling protein tyrosine phosphatase activity; regulation of compound eye photoreceptor development; sevenless signaling pathway; terminal region determination; torso signaling pathway; ventral midline development" IPR000980; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase corkscrew (EC 3.1.3.48) csw CG3954 Drosophila melanogaster (Fruit fly) TR32008_c0_g1_i2 O01802 RL7_CAEEL 1.00E-99 GO:0003723; GO:0005840 RNA binding; ribosome IPR018038; IPR016082; IPR012988; IPR005998; 60S ribosomal protein L7 rpl-7 F53G12.10 Caenorhabditis elegans TR32008_c0_g1_i3 O01802 RL7_CAEEL 5.00E-100 GO:0003723; GO:0005840 RNA binding; ribosome IPR018038; IPR016082; IPR012988; IPR005998; 60S ribosomal protein L7 rpl-7 F53G12.10 Caenorhabditis elegans TR32009_c1_g1_i1 Q49SH1 NCKX5_DANRE 2.00E-128 GO:0015297; GO:0006816; GO:0012505; GO:0016021; GO:0006813; GO:0050896; GO:0006814; GO:0015293 antiporter activity; calcium ion transport; endomembrane system; integral to membrane; potassium ion transport; response to stimulus; sodium ion transport; symporter activity IPR004481; IPR004837; Sodium/potassium/calcium exchanger 5 (Na(+)/K(+)/Ca(2+)-exchange protein 5) (Protein golden) (Solute carrier family 24 member 5) slc24a5 nckx5 Danio rerio (Zebrafish) (Brachydanio rerio) TR3201_c0_g1_i1 Q54P70 Y4757_DICDI 4.00E-06 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR003323; OTU domain-containing protein DDB_G0284757 (EC 3.1.2.-) DDB_G0284757 Dictyostelium discoideum (Slime mold) TR32010_c8_g1_i1 P35525 CLCN2_RAT 2.00E-19 GO:0015629; GO:0030554; GO:0034707; GO:0030425; GO:0030324; GO:0043204; GO:0005247 actin cytoskeleton; adenyl nucleotide binding; chloride channel complex; dendrite; lung development; perikaryon; voltage-gated chloride channel activity IPR000644; IPR002244; IPR014743; IPR001807; Chloride channel protein 2 (ClC-2) Clcn2 Rattus norvegicus (Rat) TR32011_c4_g3_i2 Q5XHF8 VIP2_XENLA 1.00E-97 GO:0005524; GO:0003993; GO:0005829; GO:0033857; GO:0052723; GO:0052724; GO:0000832; GO:0006020; GO:0000827 "ATP binding; acid phosphatase activity; cytosol; diphosphoinositol-pentakisphosphate kinase activity; inositol hexakisphosphate 1-kinase activity; inositol hexakisphosphate 3-kinase activity; inositol hexakisphosphate 5-kinase activity; inositol metabolic process; inositol-1,3,4,5,6-pentakisphosphate kinase activity" IPR000560; Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.21) (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) ppip5k2 hisppd1 vip2 Xenopus laevis (African clawed frog) TR32011_c6_g1_i3 O43314 VIP2_HUMAN 5.00E-56 GO:0005524; GO:0003993; GO:0005829; GO:0033857; GO:0052723; GO:0052724; GO:0000832; GO:0006020; GO:0043647; GO:0000827 "ATP binding; acid phosphatase activity; cytosol; diphosphoinositol-pentakisphosphate kinase activity; inositol hexakisphosphate 1-kinase activity; inositol hexakisphosphate 3-kinase activity; inositol hexakisphosphate 5-kinase activity; inositol metabolic process; inositol phosphate metabolic process; inositol-1,3,4,5,6-pentakisphosphate kinase activity" IPR000560; Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.21) (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) PPIP5K2 HISPPD1 KIAA0433 VIP2 Homo sapiens (Human) TR32013_c6_g1_i1 B3EWR1 LEC_MYTGA 1.00E-50 GO:0005534; GO:0031640 galactose binding; killing of cells of other organism Lectin (MytiLec) Mytilus galloprovincialis (Mediterranean mussel) TR32014_c2_g2_i1 Q05AT9 U1SBP_XENLA 2.00E-30 GO:0003723; GO:0000166; GO:0005634 RNA binding; nucleotide binding; nucleus IPR012677; IPR000504; U11/U12 small nuclear ribonucleoprotein 35 kDa protein (U11/U12 snRNP 35 kDa protein) (U1 snRNP-binding protein homolog) snrnp35 u1snrnpbp Xenopus laevis (African clawed frog) TR32016_c3_g2_i1 P08953 TOLL_DROME 7.00E-21 GO:0033565; GO:0008063; GO:0019732; GO:0007155; GO:0019955; GO:0050830; GO:0005769; GO:0009897; GO:0007507; GO:0035172; GO:0030097; GO:0045087; GO:0016021; GO:0006963; GO:0006967; GO:0045610; GO:0007416; GO:0016201; GO:0004888; GO:0007352 Itself; Q7K105 ESCRT-0 complex; Toll signaling pathway; antifungal humoral response; cell adhesion; cytokine binding; defense response to Gram-positive bacterium; early endosome; external side of plasma membrane; heart development; hemocyte proliferation; hemopoiesis; innate immune response; integral to membrane; positive regulation of antibacterial peptide biosynthetic process; positive regulation of antifungal peptide biosynthetic process; regulation of hemocyte differentiation; synapse assembly; synaptic target inhibition; transmembrane signaling receptor activity; zygotic specification of dorsal/ventral axis IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) TR32017_c3_g1_i1 P07314 GGT1_RAT 9.00E-95 GO:0007568; GO:0034599; GO:0005615; GO:0003840; GO:0006536; GO:0006750; GO:0006751; GO:0036374; GO:0005887; GO:0031179; GO:0032355; GO:0032496; GO:0034612 aging; cellular response to oxidative stress; extracellular space; gamma-glutamyltransferase activity; glutamate metabolic process; glutathione biosynthetic process; glutathione catabolic process; glutathione hydrolase activity; integral to plasma membrane; peptide modification; response to estradiol stimulus; response to lipopolysaccharide; response to tumor necrosis factor IPR000101; Sulfur metabolism; glutathione metabolism. Gamma-glutamyltranspeptidase 1 (GGT 1) (EC 2.3.2.2) (Gamma-glutamyltransferase 1) (Glutathione hydrolase 1) (EC 3.4.19.13) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Gamma-glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain] Ggt1 Ggt Rattus norvegicus (Rat) TR32019_c0_g1_i1 Q1L8G7 GATD1_DANRE 2.00E-64 GO:0005634; GO:0043565; GO:0003700; GO:0008270 nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; zinc ion binding IPR000679; IPR013088; GATA zinc finger domain-containing protein 1 gatad1 si:dkey-231l1.7 zgc:136582 Danio rerio (Zebrafish) (Brachydanio rerio) TR32019_c0_g1_i2 Q1L8G7 GATD1_DANRE 8.00E-65 GO:0005634; GO:0043565; GO:0003700; GO:0008270 nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; zinc ion binding IPR000679; IPR013088; GATA zinc finger domain-containing protein 1 gatad1 si:dkey-231l1.7 zgc:136582 Danio rerio (Zebrafish) (Brachydanio rerio) TR32020_c0_g1_i2 Q26619 KAPR_STRPU 4.00E-115 GO:0030552; GO:0005952; GO:0008603 cAMP binding; cAMP-dependent protein kinase complex; cAMP-dependent protein kinase regulator activity IPR002373; IPR012198; IPR003117; IPR018490; IPR018488; IPR000595; IPR014710; cAMP-dependent protein kinase type II regulatory subunit Strongylocentrotus purpuratus (Purple sea urchin) TR32022_c1_g3_i1 Q9NZJ4 SACS_HUMAN 4.00E-24 GO:0005524; GO:0030424; GO:0070852; GO:0008219; GO:0051087; GO:0030425; GO:0005739; GO:0090084; GO:0005634; GO:0006457 ATP binding; axon; cell body fiber; cell death; chaperone binding; dendrite; mitochondrion; negative regulation of inclusion body assembly; nucleus; protein folding IPR001623; IPR003594; IPR007842; IPR000626; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) TR32022_c2_g1_i6 Q9JLC8 SACS_MOUSE 3.00E-06 GO:0005524; GO:0050750; GO:0005739; GO:0090084; GO:0005634 ATP binding; low-density lipoprotein particle receptor binding; mitochondrion; negative regulation of inclusion body assembly; nucleus IPR001623; IPR003594; IPR007842; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) TR32023_c0_g1_i1 A4IGL7 PXDN_XENTR 1.00E-05 GO:0005576; GO:0020037; GO:0042744; GO:0046872; GO:0004601 extracellular region; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; IPR001007; Peroxidasin (EC 1.11.1.7) pxdn pxn Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR32023_c4_g2_i1 Q9VBW3 CAD96_DROME 6.00E-54 GO:0005524; GO:0007030; GO:0005509; GO:0016339; GO:0007156; GO:0005887; GO:0045792; GO:0004713; GO:0004714 ATP binding; Golgi organization; calcium ion binding; calcium-dependent cell-cell adhesion; homophilic cell adhesion; integral to plasma membrane; negative regulation of cell size; protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity IPR002126; IPR015919; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14) Cad96Ca HD-14 CG10244 Drosophila melanogaster (Fruit fly) TR32023_c5_g2_i4 Q64QR7 PURA_BACFR 8.00E-38 GO:0044208; GO:0005525; GO:0004019; GO:0005737; GO:0000287 'de novo' AMP biosynthetic process; GTP binding; adenylosuccinate synthase activity; cytoplasm; magnesium ion binding IPR018220; IPR001114; IPR027417; Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase) purA BF3421 Bacteroides fragilis (strain YCH46) TR32023_c5_g2_i5 P28650 PURA1_MOUSE 5.00E-83 GO:0044208; GO:0005525; GO:0004019; GO:0005737; GO:0000287; GO:0016020; GO:0006163 'de novo' AMP biosynthetic process; GTP binding; adenylosuccinate synthase activity; cytoplasm; magnesium ion binding; membrane; purine nucleotide metabolic process IPR018220; IPR001114; IPR027509; IPR027417; Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. "Adenylosuccinate synthetase isozyme 1 (AMPSase 1) (AdSS 1) (EC 6.3.4.4) (Adenylosuccinate synthetase, basic isozyme) (Adenylosuccinate synthetase, muscle isozyme) (M-type adenylosuccinate synthetase) (IMP--aspartate ligase 1)" Adssl1 Adss1 Mus musculus (Mouse) TR32023_c5_g3_i1 Q17G75 PURA_AEDAE 7.00E-98 GO:0044208; GO:0005525; GO:0004019; GO:0005737; GO:0046872 'de novo' AMP biosynthetic process; GTP binding; adenylosuccinate synthase activity; cytoplasm; metal ion binding IPR018220; IPR001114; IPR027417; Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase) AAEL003161 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR32023_c5_g3_i2 B5DGM4 PUA1C_SALSA 2.00E-81 GO:0044208; GO:0005525; GO:0004019; GO:0005737; GO:0000287 'de novo' AMP biosynthetic process; GTP binding; adenylosuccinate synthase activity; cytoplasm; magnesium ion binding IPR018220; IPR001114; IPR027509; IPR027417; Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. "Adenylosuccinate synthetase isozyme 1 C (AMPSase 1 C) (AdSS 1 C) (EC 6.3.4.4) (Adenylosuccinate synthetase, basic isozyme C) (Adenylosuccinate synthetase, muscle isozyme C) (M-type adenylosuccinate synthetase C) (IMP--aspartate ligase 1 C)" adssl1c adss1c Salmo salar (Atlantic salmon) TR32024_c2_g2_i1 Q6DHL5 LRC57_DANRE 2.00E-77 IPR001611; IPR025875; Leucine-rich repeat-containing protein 57 lrrc57 zgc:92240 Danio rerio (Zebrafish) (Brachydanio rerio) TR32028_c1_g1_i2 Q16932 STX_APLCA 8.00E-20 GO:0016021; GO:0006886; GO:0006836; GO:0016192 integral to membrane; intracellular protein transport; neurotransmitter transport; vesicle-mediated transport IPR015708; IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin Aplysia californica (California sea hare) TR32030_c0_g1_i1 P74615 Y1483_SYNY3 2.00E-26 GO:0030288 outer membrane-bounded periplasmic space IPR000782; Uncharacterized protein sll1483 sll1483 Synechocystis sp. (strain PCC 6803 / Kazusa) TR32032_c0_g1_i1 Q1LUI2 HDDC2_DANRE 2.00E-71 GO:0008152; GO:0046872; GO:0008081 metabolic process; metal ion binding; phosphoric diester hydrolase activity IPR003607; IPR006674; HD domain-containing protein 2 hddc2 si:ch211-208c9.2 zgc:112330 Danio rerio (Zebrafish) (Brachydanio rerio) TR32033_c2_g1_i1 Q04956 ATX1_PLAFA 5.00E-27 GO:0005524; GO:0019829; GO:0016021; GO:0046872 ATP binding; cation-transporting ATPase activity; integral to membrane; metal ion binding IPR023299; IPR018303; IPR008250; IPR001757; IPR023214; Probable cation-transporting ATPase 1 (EC 3.6.3.-) Plasmodium falciparum TR32033_c2_g1_i2 Q9H7F0 AT133_HUMAN 0 GO:0005524; GO:0006200; GO:0019829; GO:0016021; GO:0046872 ATP binding; ATP catabolic process; cation-transporting ATPase activity; integral to membrane; metal ion binding IPR004014; IPR006544; IPR023299; IPR018303; IPR008250; IPR001757; IPR023214; Probable cation-transporting ATPase 13A3 (EC 3.6.3.-) (ATPase family homolog up-regulated in senescence cells 1) ATP13A3 AFURS1 Homo sapiens (Human) TR32033_c2_g1_i4 Q9H7F0 AT133_HUMAN 0 GO:0005524; GO:0006200; GO:0019829; GO:0016021; GO:0046872 ATP binding; ATP catabolic process; cation-transporting ATPase activity; integral to membrane; metal ion binding IPR004014; IPR006544; IPR023299; IPR018303; IPR008250; IPR001757; IPR023214; Probable cation-transporting ATPase 13A3 (EC 3.6.3.-) (ATPase family homolog up-regulated in senescence cells 1) ATP13A3 AFURS1 Homo sapiens (Human) TR32037_c0_g1_i1 F6VSS6 TRM5_XENTR 2.00E-124 GO:0005759; GO:0005634; GO:0052906 mitochondrial matrix; nucleus; tRNA (guanine(37)-N(1))-methyltransferase activity IPR025792; IPR003402; tRNA (guanine(37)-N1)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (tRNA methyltransferase 5 homolog) trmt5 trm5 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR32038_c1_g1_i1 P53042 PPP5_RAT 0 GO:0005794; GO:0005737; GO:0016020; GO:0046872; GO:0043005; GO:0043025; GO:0005634; GO:0004721; GO:0043123; GO:0006470; GO:0051291; GO:0004871 Golgi apparatus; cytoplasm; membrane; metal ion binding; neuron projection; neuronal cell body; nucleus; phosphoprotein phosphatase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein dephosphorylation; protein heterooligomerization; signal transducer activity IPR004843; IPR013235; IPR006186; IPR011236; IPR013026; IPR011990; IPR001440; IPR019734; Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PPT) Ppp5c Rattus norvegicus (Rat) TR32039_c6_g1_i1 P27398 CAND_DROME 5.00E-39 GO:0004198; GO:0005737; GO:0007399; GO:0006508; GO:0050896; GO:0007601; GO:0008270 calcium-dependent cysteine-type endopeptidase activity; cytoplasm; nervous system development; proteolysis; response to stimulus; visual perception; zinc ion binding IPR022684; IPR000169; IPR001300; IPR001876; Calpain-D (EC 3.4.22.-) (Calcium-activated neutral proteinase D) (CANP D) (Small optic lobes protein) sol CalpD CG1391 Drosophila melanogaster (Fruit fly) TR32039_c6_g2_i1 Q9TTH8 CAN3_SHEEP 3.00E-13 GO:0030315; GO:0030018; GO:0005509; GO:0004198; GO:0071277; GO:0071472; GO:0005829; GO:0055103; GO:0043066; GO:0033234; GO:0045892; GO:0005634; GO:0051092; GO:0045862; GO:0051281; GO:0014718; GO:0045893; GO:0043234; GO:0006461; GO:0032947; GO:0072657; GO:0043122; GO:0014850; GO:0045214; GO:0097264; GO:0031402; GO:0008307; GO:0031432 "T-tubule; Z disc; calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cellular response to calcium ion; cellular response to salt stress; cytosol; ligase regulator activity; negative regulation of apoptotic process; negative regulation of protein sumoylation; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of proteolysis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of satellite cell activation involved in skeletal muscle regeneration; positive regulation of transcription, DNA-dependent; protein complex; protein complex assembly; protein complex scaffold; protein localization to membrane; regulation of I-kappaB kinase/NF-kappaB cascade; response to muscle activity; sarcomere organization; self proteolysis; sodium ion binding; structural constituent of muscle; titin binding" IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) (New calpain 1) (nCL-1) CAPN3 NCL1 Ovis aries (Sheep) TR32039_c6_g3_i1 P27398 CAND_DROME 2.00E-120 GO:0004198; GO:0005737; GO:0007399; GO:0006508; GO:0050896; GO:0007601; GO:0008270 calcium-dependent cysteine-type endopeptidase activity; cytoplasm; nervous system development; proteolysis; response to stimulus; visual perception; zinc ion binding IPR022684; IPR000169; IPR001300; IPR001876; Calpain-D (EC 3.4.22.-) (Calcium-activated neutral proteinase D) (CANP D) (Small optic lobes protein) sol CalpD CG1391 Drosophila melanogaster (Fruit fly) TR32041_c1_g1_i1 P0C870 JMJD7_HUMAN 5.00E-07 IPR003347; JmjC domain-containing protein 7 (Jumonji domain-containing protein 7) JMJD7 Homo sapiens (Human) TR32042_c0_g1_i2 Q9Y1A3 TIM8_DROME 5.00E-22 GO:0046872; GO:0005743; GO:0015031 metal ion binding; mitochondrial inner membrane; protein transport IPR004217; Mitochondrial import inner membrane translocase subunit Tim8 Tim8 CG1728 Drosophila melanogaster (Fruit fly) TR32042_c0_g1_i4 P0CR94 TIM8_CRYNJ 1.00E-10 GO:0046872; GO:0005743; GO:0015031 metal ion binding; mitochondrial inner membrane; protein transport IPR004217; Mitochondrial import inner membrane translocase subunit TIM8 TIM8 CNF01290 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR32042_c0_g1_i5 Q9Y1A3 TIM8_DROME 5.00E-22 GO:0046872; GO:0005743; GO:0015031 metal ion binding; mitochondrial inner membrane; protein transport IPR004217; Mitochondrial import inner membrane translocase subunit Tim8 Tim8 CG1728 Drosophila melanogaster (Fruit fly) TR32043_c0_g1_i2 Q9XUE6 PMM_CAEEL 1.00E-99 GO:0009298; GO:0005737; GO:0019307; GO:0004615 GDP-mannose biosynthetic process; cytoplasm; mannose biosynthetic process; phosphomannomutase activity IPR023214; IPR006379; IPR005002; Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2. Probable phosphomannomutase (PMM) (EC 5.4.2.8) F52B11.2 Caenorhabditis elegans TR32044_c1_g2_i2 Q09621 LACT2_CAEEL 3.00E-50 GO:0016021 integral to membrane IPR001466; IPR012338; Beta-lactamase domain-containing protein 2 lact-2 ZK945.1 Caenorhabditis elegans TR32048_c1_g1_i2 Q67XX3 FB252_ARATH 3.00E-13 GO:0000987; GO:0043985; GO:0005634; GO:0010030 core promoter proximal region sequence-specific DNA binding; histone H4-R3 methylation; nucleus; positive regulation of seed germination IPR001810; IPR003347; F-box protein At5g06550 At5g06550 F15M7.8 Arabidopsis thaliana (Mouse-ear cress) TR32049_c0_g1_i1 P84798 DPOD3_BOVIN 2.00E-28 GO:0006260; GO:0003887; GO:0005634 DNA replication; DNA-directed DNA polymerase activity; nucleus IPR019038; DNA polymerase delta subunit 3 (DNA polymerase delta subunit p66) (p68) POLD3 Bos taurus (Bovine) TR32049_c0_g1_i4 Q9EQ28 DPOD3_MOUSE 1.00E-25 GO:0006260; GO:0003887; GO:0006297; GO:0005634 "DNA replication; DNA-directed DNA polymerase activity; nucleotide-excision repair, DNA gap filling; nucleus" IPR019038; DNA polymerase delta subunit 3 (DNA polymerase delta subunit p66) Pold3 Mus musculus (Mouse) TR32050_c0_g1_i1 O14715 RGPD8_HUMAN 8.00E-12 GO:0008536; GO:0005643; GO:0000042 Ran GTPase binding; nuclear pore; protein targeting to Golgi IPR000237; IPR011993; IPR000156; IPR013026; IPR011990; IPR001440; IPR019734; RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) RGPD8 RANBP2ALPHA RANBP2L1 RANBP2L3 Homo sapiens (Human) TR32050_c0_g1_i3 Q99666 RGPD5_HUMAN 7.00E-21 GO:0005737; GO:0000042 cytoplasm; protein targeting to Golgi IPR000237; IPR011993; IPR000156; IPR013026; IPR011990; IPR001440; IPR019734; RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) RGPD5 RANBP2L1 RGP5 RGP7 RGPD7; RGPD6 RANBP2L2 RGP6 Homo sapiens (Human) TR32051_c2_g1_i1 Q99RF5 Y2478_STAAM 3.00E-38 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; Uncharacterized oxidoreductase SAV2478 (EC 1.-.-.-) SAV2478 Staphylococcus aureus (strain Mu50 / ATCC 700699) TR32051_c2_g1_i2 Q71R50 DHR11_CHICK 1.00E-109 GO:0005576; GO:0016491 extracellular region; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Dehydrogenase/reductase SDR family member 11 (EC 1.-.-.-) DHRS11 Gallus gallus (Chicken) TR32053_c0_g1_i2 C3YWU0 FUCO_BRAFL 0 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR32054_c0_g1_i1 Q9VN14 CONT_DROME 4.00E-48 GO:0031225; GO:0008366; GO:0030246; GO:0061343; GO:0060857; GO:0045197; GO:0021682; GO:0005886; GO:0005918; GO:0019991 anchored to membrane; axon ensheathment; carbohydrate binding; cell adhesion involved in heart morphogenesis; establishment of glial blood-brain barrier; establishment or maintenance of epithelial cell apical/basal polarity; nerve maturation; plasma membrane; septate junction; septate junction assembly IPR001304; IPR016186; IPR016187; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Contactin Cont CG1084 Drosophila melanogaster (Fruit fly) TR32054_c1_g1_i1 Q95SX7 RTBS_DROME 1.00E-09 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR32054_c1_g1_i2 P97685 NFASC_RAT 4.00E-12 GO:0097454; GO:0007411; GO:0043194; GO:0045162; GO:0034113; GO:0016021; GO:0005622; GO:0042552; GO:0033268; GO:0033010; GO:0030913; GO:0033270; GO:0007422; GO:0005886; GO:0071205; GO:0002175; GO:0072661; GO:0050808 Schwann cell microvillus; axon guidance; axon initial segment; clustering of voltage-gated sodium channels; heterotypic cell-cell adhesion; integral to membrane; intracellular; myelination; node of Ranvier; paranodal junction; paranodal junction assembly; paranode region of axon; peripheral nervous system development; plasma membrane; protein localization to juxtaparanode region of axon; protein localization to paranode region of axon; protein targeting to plasma membrane; synapse organization IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR026966; IPR026965; Neurofascin Nfasc Rattus norvegicus (Rat) TR32054_c1_g1_i4 Q95SX7 RTBS_DROME 8.00E-10 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR32054_c1_g1_i5 Q9VN14 CONT_DROME 3.00E-38 GO:0031225; GO:0008366; GO:0030246; GO:0061343; GO:0060857; GO:0045197; GO:0021682; GO:0005886; GO:0005918; GO:0019991 anchored to membrane; axon ensheathment; carbohydrate binding; cell adhesion involved in heart morphogenesis; establishment of glial blood-brain barrier; establishment or maintenance of epithelial cell apical/basal polarity; nerve maturation; plasma membrane; septate junction; septate junction assembly IPR001304; IPR016186; IPR016187; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Contactin Cont CG1084 Drosophila melanogaster (Fruit fly) TR32054_c1_g1_i8 Q8IVU1 IGDC3_HUMAN 1.00E-07 GO:0005887; GO:0050885 integral to plasma membrane; neuromuscular process controlling balance IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; Immunoglobulin superfamily DCC subclass member 3 (Putative neuronal cell adhesion molecule) IGDCC3 PUNC Homo sapiens (Human) TR32058_c0_g1_i3 A4FV08 GNPI1_BOVIN 7.00E-166 GO:0006044; GO:0005975; GO:0005737; GO:0006091; GO:0006043; GO:0004342; GO:0016787 N-acetylglucosamine metabolic process; carbohydrate metabolic process; cytoplasm; generation of precursor metabolites and energy; glucosamine catabolic process; glucosamine-6-phosphate deaminase activity; hydrolase activity IPR006148; IPR004547; IPR018321; Glucosamine-6-phosphate isomerase 1 (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase 1) (GNPDA 1) (GlcN6P deaminase 1) (Oscillin) GNPDA1 Bos taurus (Bovine) TR32059_c2_g1_i2 Q9Y6N9 USH1C_HUMAN 1.00E-77 GO:0000086; GO:0045177; GO:0042491; GO:0005737; GO:0005856; GO:0005829; GO:0050957; GO:0042472; GO:0030046; GO:0045494; GO:0001917; GO:0001750; GO:0005886; GO:0050953; GO:0007605; GO:0032420; GO:0045202 G2/M transition of mitotic cell cycle; apical part of cell; auditory receptor cell differentiation; cytoplasm; cytoskeleton; cytosol; equilibrioception; inner ear morphogenesis; parallel actin filament bundle assembly; photoreceptor cell maintenance; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; sensory perception of light stimulus; sensory perception of sound; stereocilium; synapse IPR001478; Harmonin (Antigen NY-CO-38/NY-CO-37) (Autoimmune enteropathy-related antigen AIE-75) (Protein PDZ-73) (Renal carcinoma antigen NY-REN-3) (Usher syndrome type-1C protein) USH1C AIE75 Homo sapiens (Human) TR32060_c2_g1_i2 Q3T093 NECP1_BOVIN 8.00E-77 GO:0030125; GO:0005905; GO:0006897; GO:0005886; GO:0015031 clathrin vesicle coat; coated pit; endocytosis; plasma membrane; protein transport IPR012466; IPR011993; Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1) NECAP1 Bos taurus (Bovine) TR32062_c0_g1_i1 Q8C9A2 ENDOV_MOUSE 4.00E-85 GO:0006281; GO:0005737; GO:0016888; GO:0016891; GO:0000287; GO:0005730; GO:0003727; GO:0043566 "DNA repair; cytoplasm; endodeoxyribonuclease activity, producing 5'-phosphomonoesters; endoribonuclease activity, producing 5'-phosphomonoesters; magnesium ion binding; nucleolus; single-stranded RNA binding; structure-specific DNA binding" IPR007581; Endonuclease V (EC 3.1.26.-) Endov Mus musculus (Mouse) TR32064_c4_g1_i1 Q6GM29 SAC1_XENLA 7.00E-145 GO:0005789; GO:0016021; GO:0016791 endoplasmic reticulum membrane; integral to membrane; phosphatase activity IPR002013; Phosphatidylinositide phosphatase SAC1 (EC 3.1.3.-) (Suppressor of actin mutations 1-like protein) sacm1l Xenopus laevis (African clawed frog) TR32064_c4_g1_i2 Q9W0I6 SAC1_DROME 1.00E-108 GO:0030424; GO:0016199; GO:0046664; GO:0005789; GO:0016021; GO:0046329; GO:0043025; GO:0052866; GO:0071683 "axon; axon midline choice point recognition; dorsal closure, amnioserosa morphology change; endoplasmic reticulum membrane; integral to membrane; negative regulation of JNK cascade; neuronal cell body; phosphatidylinositol phosphate phosphatase activity; sensory dendrite" IPR002013; Phosphatidylinositide phosphatase SAC1 (EC 3.1.3.-) (Suppressor of actin mutations 1-like protein) Sac1 Sacm1l CG9128 Drosophila melanogaster (Fruit fly) TR32065_c2_g1_i1 P23666 GUN2_PERAE 1.00E-10 GO:0008810; GO:0030245; GO:0009835 cellulase activity; cellulose catabolic process; fruit ripening IPR008928; IPR012341; IPR001701; IPR018221; "Endoglucanase 2 (EC 3.2.1.4) (Abscission cellulase 2) (Endo-1,4-beta-glucanase 2) (Fragment)" CEL2 Persea americana (Avocado) TR32065_c2_g1_i3 P26221 GUN4_THEFU 7.00E-98 GO:0008810; GO:0030248; GO:0030245 cellulase activity; cellulose binding; cellulose catabolic process IPR008928; IPR012341; IPR008965; IPR001956; IPR012291; IPR018366; IPR001919; IPR003961; IPR001701; IPR018221; IPR013783; Glycan metabolism; cellulose degradation. "Endoglucanase E-4 (EC 3.2.1.4) (Cellulase E-4) (Cellulase E4) (Endo-1,4-beta-glucanase E-4)" celD Thermobifida fusca (Thermomonospora fusca) TR32067_c2_g1_i1 Q9P7B3 YI14_SCHPO 4.00E-38 GO:0008324; GO:0005783; GO:0005789; GO:0016021 cation transmembrane transporter activity; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane IPR005185; IPR004837; Putative cation exchanger C521.04c SPAC521.04c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR32067_c4_g1_i1 Q39253 CAX1_ARATH 2.00E-08 GO:0015369; GO:0030026; GO:0006882; GO:0009631; GO:0016021; GO:0055062; GO:0009705; GO:0009651; GO:0005774 Q93Z81 calcium:hydrogen antiporter activity; cellular manganese ion homeostasis; cellular zinc ion homeostasis; cold acclimation; integral to membrane; phosphate ion homeostasis; plant-type vacuole membrane; response to salt stress; vacuolar membrane IPR004713; IPR004798; IPR004837; Vacuolar cation/proton exchanger 1 (Ca(2+)/H(+) antiporter CAX1) (Ca(2+)/H(+) exchanger 1) (Protein CATION EXCHANGER 1) (Protein RARE COLD INDUCIBLE 4) CAX1 RCI4 At2g38170 F16M14.10 Arabidopsis thaliana (Mouse-ear cress) TR32067_c4_g1_i2 Q769E5 CAX1A_ORYSJ 7.00E-13 GO:0015369; GO:0016021; GO:0005774 calcium:hydrogen antiporter activity; integral to membrane; vacuolar membrane IPR004713; IPR004798; IPR004837; Vacuolar cation/proton exchanger 1a (Ca(2+)/H(+) exchanger 1a) (OsCAX1a) CAX1a Os01g0557500 LOC_Os01g37690 B1144D11.14 OJ1014_G12.40 Oryza sativa subsp. japonica (Rice) TR32070_c0_g1_i1 Q8ISN9 RS25_BRABE 3.00E-28 GO:0005840 ribosome IPR004977; 40S ribosomal protein S25 RPS25 Branchiostoma belcheri (Amphioxus) TR32072_c4_g1_i1 Q1L9A2 OPA3_DANRE 1.00E-22 GO:0007626; GO:0005739; GO:0050881; GO:0031413 locomotory behavior; mitochondrion; musculoskeletal movement; regulation of buoyancy IPR010754; Optic atrophy 3 protein homolog opa3 si:dkey-12o15.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR32075_c0_g1_i1 O18404 HCD2_DROME 3.00E-131 GO:0047015; GO:0003857; GO:0047022; GO:0018454; GO:0006637; GO:0008209; GO:0005829; GO:0008205; GO:0004303; GO:0008210; GO:0006631; GO:0005811; GO:0005875; GO:0005739; GO:0008033; GO:0047035; GO:0030283 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity; 3-hydroxyacyl-CoA dehydrogenase activity; 7-beta-hydroxysteroid dehydrogenase (NADP+) activity; acetoacetyl-CoA reductase activity; acyl-CoA metabolic process; androgen metabolic process; cytosol; ecdysone metabolic process; estradiol 17-beta-dehydrogenase activity; estrogen metabolic process; fatty acid metabolic process; lipid particle; microtubule associated complex; mitochondrion; tRNA processing; testosterone dehydrogenase (NAD+) activity; testosterone dehydrogenase [NAD(P)] activity IPR002198; IPR002347; IPR016040; IPR020904; 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Scully protein) (Type II HADH) scu CG7113 Drosophila melanogaster (Fruit fly) TR32077_c0_g1_i1 Q6ZNE5 BAKOR_HUMAN 5.00E-55 GO:0005776; GO:0000045; GO:0005789; GO:0010508; GO:0034045 Q14457 autophagic vacuole; autophagic vacuole assembly; endoplasmic reticulum membrane; positive regulation of autophagy; pre-autophagosomal structure membrane IPR018791; Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L) ATG14 KIAA0831 Homo sapiens (Human) TR32080_c0_g1_i1 O88329 MYO1A_MOUSE 1.00E-122 GO:0005524; GO:0016324; GO:0009925; GO:0005903; GO:0030864; GO:0031941; GO:0016328; GO:0005902; GO:0030033; GO:0003774; GO:0016459; GO:0007605; GO:0051648 ATP binding; apical plasma membrane; basal plasma membrane; brush border; cortical actin cytoskeleton; filamentous actin; lateral plasma membrane; microvillus; microvillus assembly; motor activity; myosin complex; sensory perception of sound; vesicle localization IPR000048; IPR001609; IPR010926; IPR027417; Unconventional myosin-Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC) Myo1a Bbmi Myhl Mus musculus (Mouse) TR32080_c0_g1_i2 Q5ZLA6 MYO1C_CHICK 4.00E-150 GO:0005524; GO:0005737; GO:0003774; GO:0016459; GO:0060171 ATP binding; cytoplasm; motor activity; myosin complex; stereocilium membrane IPR000048; IPR001609; IPR010926; IPR027417; Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) MYO1C RCJMB04_6o17 Gallus gallus (Chicken) TR32081_c0_g1_i1 O18413 PRS8_DROME 0 GO:0005524; GO:0005737; GO:0005875; GO:0017111; GO:0005634; GO:0043161; GO:0008540; GO:0006974 "ATP binding; cytoplasm; microtubule associated complex; nucleoside-triphosphatase activity; nucleus; proteasomal ubiquitin-dependent protein catabolic process; proteasome regulatory particle, base subcomplex; response to DNA damage stimulus" IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 8 Pros45 DUG Ug CG1489 Drosophila melanogaster (Fruit fly) TR32082_c0_g1_i1 A5D8N2 DPCD_XENLA 6.00E-65 IPR026224; Protein DPCD dpcd Xenopus laevis (African clawed frog) TR32084_c1_g1_i2 O60941 DTNB_HUMAN 2.00E-146 GO:0005509; GO:0005737; GO:0045202; GO:0008270 calcium ion binding; cytoplasm; synapse; zinc ion binding IPR017432; IPR011992; IPR015153; IPR015154; IPR000433; Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) DTNB Homo sapiens (Human) TR32084_c1_g1_i4 Q6GPB6 KCMF1_XENLA 3.00E-07 GO:0016874; GO:0008270 ligase activity; zinc ion binding IPR008598; IPR007087; IPR015880; IPR000433; E3 ubiquitin-protein ligase KCMF1 (EC 6.3.2.-) kcmf1 Xenopus laevis (African clawed frog) TR32084_c1_g1_i5 Q7YU29 DMDE_DROME 4.00E-42 GO:0003779; GO:0005509; GO:0005737; GO:0005856; GO:0016010; GO:0030010; GO:0008586; GO:0007474; GO:0046716; GO:0007517; GO:0007274; GO:0046928; GO:0048172; GO:0042383; GO:0005198; GO:0045202; GO:0008270 actin binding; calcium ion binding; cytoplasm; cytoskeleton; dystrophin-associated glycoprotein complex; establishment of cell polarity; imaginal disc-derived wing vein morphogenesis; imaginal disc-derived wing vein specification; muscle cell cellular homeostasis; muscle organ development; neuromuscular synaptic transmission; regulation of neurotransmitter secretion; regulation of short-term neuronal synaptic plasticity; sarcolemma; structural molecule activity; synapse; zinc ion binding IPR011992; IPR015153; IPR015154; IPR018159; IPR001202; IPR000433; "Dystrophin, isoform E (Protein detached)" Dys det CG34157 Drosophila melanogaster (Fruit fly) TR32084_c1_g1_i6 Q9Y048 DTN1_CAEEL 2.00E-38 GO:0005277; GO:0015870; GO:0005509; GO:0005737; GO:0016014; GO:0007529; GO:0007626; GO:0046716; GO:0040017; GO:0032224; GO:0045214; GO:0007271; GO:0008270 Q9TW65 "acetylcholine transmembrane transporter activity; acetylcholine transport; calcium ion binding; cytoplasm; dystrobrevin complex; establishment of synaptic specificity at neuromuscular junction; locomotory behavior; muscle cell cellular homeostasis; positive regulation of locomotion; positive regulation of synaptic transmission, cholinergic; sarcomere organization; synaptic transmission, cholinergic; zinc ion binding" IPR017432; IPR011992; IPR015153; IPR015154; IPR000433; Dystrobrevin-1 dyb-1 F47G6.1 Caenorhabditis elegans TR32084_c1_g2_i1 Q9Y4J8 DTNA_HUMAN 2.00E-50 GO:0005509; GO:0030054; GO:0005737; GO:0007274; GO:0005886; GO:0043234; GO:0007165; GO:0006941; GO:0045202; GO:0008270 calcium ion binding; cell junction; cytoplasm; neuromuscular synaptic transmission; plasma membrane; protein complex; signal transduction; striated muscle contraction; synapse; zinc ion binding IPR017432; IPR011992; IPR015153; IPR015154; IPR000433; Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) DTNA DRP3 Homo sapiens (Human) TR32086_c2_g1_i1 Q8R2R5 LRC61_MOUSE 4.00E-43 IPR001611; IPR025875; Leucine-rich repeat-containing protein 61 Lrrc61 Mus musculus (Mouse) TR32088_c4_g3_i11 Q9R044 NPHN_RAT 6.00E-07 GO:0007155; GO:0003094; GO:0016021; GO:0045121; GO:0007517; GO:0005886; GO:0043234; GO:0036057 P97710 cell adhesion; glomerular filtration; integral to membrane; membrane raft; muscle organ development; plasma membrane; protein complex; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Rattus norvegicus (Rat) TR32088_c4_g3_i15 Q8N8K9 K1958_HUMAN 2.00E-17 IPR021893; Uncharacterized protein KIAA1958 KIAA1958 Homo sapiens (Human) TR32088_c4_g3_i3 P13590 NCAM1_CHICK 2.00E-10 GO:0007155; GO:0016021; GO:0005886 cell adhesion; integral to membrane; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR009138; Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) NCAM1 Gallus gallus (Chicken) TR32088_c4_g3_i6 Q8N8K9 K1958_HUMAN 2.00E-17 IPR021893; Uncharacterized protein KIAA1958 KIAA1958 Homo sapiens (Human) TR32088_c4_g3_i8 O60500 NPHN_HUMAN 4.00E-11 GO:0007254; GO:0007155; GO:0042995; GO:0007588; GO:0032836; GO:0072015; GO:0005887; GO:0007520; GO:0030838; GO:0044062; GO:0007519; GO:0036057 P46940; P16333 JNK cascade; cell adhesion; cell projection; excretion; glomerular basement membrane development; glomerular visceral epithelial cell development; integral to plasma membrane; myoblast fusion; positive regulation of actin filament polymerization; regulation of excretion; skeletal muscle tissue development; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) NPHS1 NPHN Homo sapiens (Human) TR32089_c0_g1_i1 A0JM12 MEG10_XENTR 2.00E-23 GO:0007155; GO:0016021; GO:0006909; GO:0005886; GO:0014719; GO:0014816; GO:0014841 cell adhesion; integral to membrane; phagocytosis; plasma membrane; satellite cell activation; satellite cell differentiation; satellite cell proliferation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR32092_c3_g1_i2 Q9BQQ7 RTP3_HUMAN 2.00E-10 GO:0005737; GO:0001580; GO:0016021; GO:0006612 cytoplasm; detection of chemical stimulus involved in sensory perception of bitter taste; integral to membrane; protein targeting to membrane IPR026096; IPR026691; IPR027377; Receptor-transporting protein 3 (Transmembrane protein 7) RTP3 TMEM7 Homo sapiens (Human) TR32095_c1_g1_i1 P41044 CAB32_DROME 5.00E-110 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calbindin-32 Cbp53E cbn CG6702 Drosophila melanogaster (Fruit fly) TR32095_c1_g1_i3 P41044 CAB32_DROME 8.00E-109 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calbindin-32 Cbp53E cbn CG6702 Drosophila melanogaster (Fruit fly) TR32096_c0_g2_i3 Q05B60 NUD14_BOVIN 1.00E-47 GO:0047631; GO:0008768; GO:0005737; GO:0046872 ADP-ribose diphosphatase activity; UDP-sugar diphosphatase activity; cytoplasm; metal ion binding IPR004385; IPR000086; IPR015797; Uridine diphosphate glucose pyrophosphatase (UDPG pyrophosphatase) (UGPPase) (EC 3.6.1.45) (Nucleoside diphosphate-linked moiety X motif 14) (Nudix motif 14) NUDT14 UGPP Bos taurus (Bovine) TR32097_c0_g1_i1 Q58A42 DD3_DICDI 1.00E-99 GO:0016021 integral to membrane Protein DD3-3 DD3-3 DDB_G0283095 Dictyostelium discoideum (Slime mold) TR32099_c0_g1_i1 Q9DE26 RUVB1_XENLA 0 GO:0005524; GO:0043141; GO:0032508; GO:0006310; GO:0006281; GO:0071339; GO:0006355; GO:0006351 "ATP binding; ATP-dependent 5'-3' DNA helicase activity; DNA duplex unwinding; DNA recombination; DNA repair; MLL1 complex; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003593; IPR027417; IPR027238; IPR010339; RuvB-like 1 (EC 3.6.4.12) (Pontin) ruvbl1 Xenopus laevis (African clawed frog) TR32100_c1_g1_i1 O62515 PAHX_CAEEL 9.00E-09 GO:0031418; GO:0006631; GO:0046872; GO:0048244 L-ascorbic acid binding; fatty acid metabolic process; metal ion binding; phytanoyl-CoA dioxygenase activity IPR008775; Lipid metabolism; fatty acid metabolism. Probable phytanoyl-CoA dioxygenase (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH) ZK550.6 Caenorhabditis elegans TR32100_c1_g1_i3 Q829L6 ECTD_STRAW 5.00E-11 GO:0016725 "oxidoreductase activity, acting on CH or CH2 groups" IPR012774; IPR008775; Ectoine hydroxylase (EC 1.17.-.-) ectD SAV_6395 Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680) TR32101_c0_g2_i1 O42282 RDS2_CHICK 4.00E-25 GO:0016021; GO:0007601 integral to membrane; visual perception IPR000830; IPR018498; IPR018499; IPR008952; Photoreceptor outer segment membrane glycoprotein 2 (CRDS2) Gallus gallus (Chicken) TR32102_c0_g1_i1 Q5RF82 MSTO1_PONPY 1.00E-114 GO:0005741; GO:0048311 mitochondrial outer membrane; mitochondrion distribution IPR019605; IPR003008; Protein misato homolog 1 MSTO1 Pongo pygmaeus (Bornean orangutan) TR32103_c1_g1_i2 Q6EEF3 TTLL5_CHLAE 9.00E-30 GO:0006464; GO:0005929; GO:0005737; GO:0016874; GO:0005932; GO:0005634; GO:0006351 "cellular protein modification process; cilium; cytoplasm; ligase activity; microtubule basal body; nucleus; transcription, DNA-dependent" IPR004344; Tubulin polyglutamylase TTLL5 (EC 6.-.-.-) (SRC1 and TIF2-associated modulatory protein) (Tubulin--tyrosine ligase-like protein 5) TTLL5 STAMP Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) TR32103_c4_g1_i1 Q8CHB8 TTLL5_MOUSE 3.00E-61 GO:0005813; GO:0005929; GO:0005737; GO:0009566; GO:0016874; GO:0005932; GO:0005634; GO:0018095; GO:0007288; GO:0030317; GO:0006351 "centrosome; cilium; cytoplasm; fertilization; ligase activity; microtubule basal body; nucleus; protein polyglutamylation; sperm axoneme assembly; sperm motility; transcription, DNA-dependent" IPR004344; Tubulin polyglutamylase TTLL5 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 5) Ttll5 Kiaa0998 Mus musculus (Mouse) TR32104_c0_g1_i1 Q34947 NU5M_LUMTE 2.00E-138 GO:0042773; GO:0008137; GO:0016021; GO:0005743; GO:0070469 ATP synthesis coupled electron transport; NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial inner membrane; respiratory chain IPR010934; IPR001750; IPR001516; NADH-ubiquinone oxidoreductase chain 5 (EC 1.6.5.3) (NADH dehydrogenase subunit 5) ND5 Lumbricus terrestris (Common earthworm) TR32105_c4_g1_i2 B0JZG0 S23A2_XENTR 6.00E-70 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR006042; IPR006043; Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR32107_c2_g1_i1 Q9H3E2 SNX25_HUMAN 4.00E-90 GO:0007154; GO:0010008; GO:0035091; GO:0015031; GO:0038032 cell communication; endosome membrane; phosphatidylinositol binding; protein transport; termination of G-protein coupled receptor signaling pathway IPR001683; IPR003114; IPR016137; IPR000342; IPR013937; Sorting nexin-25 SNX25 MSTP043 Homo sapiens (Human) TR32108_c5_g1_i1 O15027 SC16A_HUMAN 4.00E-75 GO:0048208; GO:0000139; GO:0005829; GO:0005789; GO:0007029; GO:0015031 COPII vesicle coating; Golgi membrane; cytosol; endoplasmic reticulum membrane; endoplasmic reticulum organization; protein transport IPR024880; IPR024340; Protein transport protein Sec16A (SEC16 homolog A) SEC16A KIAA0310 SEC16 SEC16L Homo sapiens (Human) TR32108_c6_g1_i2 P34643 YOQ5_CAEEL 1.00E-08 GO:0048208; GO:0070971; GO:0032527; GO:0070973 COPII vesicle coating; endoplasmic reticulum exit site; protein exit from endoplasmic reticulum; protein localization to endoplasmic reticulum exit site IPR024880; IPR024340; Uncharacterized protein ZK512.5 ZK512.5 Caenorhabditis elegans TR32108_c7_g1_i1 P34643 YOQ5_CAEEL 2.00E-07 GO:0048208; GO:0070971; GO:0032527; GO:0070973 COPII vesicle coating; endoplasmic reticulum exit site; protein exit from endoplasmic reticulum; protein localization to endoplasmic reticulum exit site IPR024880; IPR024340; Uncharacterized protein ZK512.5 ZK512.5 Caenorhabditis elegans TR32109_c0_g1_i1 P35231 REG3A_RAT 1.00E-11 GO:0006953; GO:0030246; GO:0005576; GO:0045617; GO:0010838; GO:0090303 acute-phase response; carbohydrate binding; extracellular region; negative regulation of keratinocyte differentiation; positive regulation of keratinocyte proliferation; positive regulation of wound healing IPR001304; IPR016186; IPR018378; IPR016187; Regenerating islet-derived protein 3-alpha (REG-3-alpha) (Islet of Langerhans regenerating protein 3) (REG 3) (Lithostathine 3) (Pancreatitis-associated protein 2) (RegIII) (Regenerating islet-derived protein III-alpha) (Reg III-alpha) [Cleaved into: Regenerating islet-derived protein 3-alpha 16.5 kDa form; Regenerating islet-derived protein 3-alpha 15 kDa form] Reg3a Pap2 Reg3 Rattus norvegicus (Rat) TR32109_c0_g1_i2 Q62059 CSPG2_MOUSE 3.00E-20 GO:0005509; GO:0030246; GO:0007155; GO:0007507; GO:0005540; GO:0005578; GO:0001657 calcium ion binding; carbohydrate binding; cell adhesion; heart development; hyaluronic acid binding; proteinaceous extracellular matrix; ureteric bud development IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Large fibroblast proteoglycan) (PG-M) Vcan Cspg2 Mus musculus (Mouse) TR32109_c0_g1_i3 Q6ZS10 CL17A_HUMAN 6.00E-19 GO:0009986; GO:0042806; GO:0016021; GO:0005537; GO:0046872 cell surface; fucose binding; integral to membrane; mannose binding; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; "C-type lectin domain family 17, member A (Prolectin)" CLEC17A Homo sapiens (Human) TR32109_c0_g1_i4 Q28343 PGCA_CANFA 1.00E-23 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003006; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Canis familiaris (Dog) (Canis lupus familiaris) TR32109_c0_g1_i5 Q90953 CSPG2_CHICK 8.00E-20 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Gallus gallus (Chicken) TR32110_c1_g1_i1 Q28XE2 AN32A_DROPS 3.00E-07 GO:0005783; GO:0006913; GO:0005634; GO:0048471 endoplasmic reticulum; nucleocytoplasmic transport; nucleus; perinuclear region of cytoplasm IPR001611; IPR003603; Acidic leucine-rich nuclear phosphoprotein 32 family member A Anp32a Mapmodulin GA19125 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR32116_c1_g1_i1 A4T2J0 NDK_MYCGI 1.00E-18 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0005737; GO:0046872; GO:0004550 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; cytoplasm; metal ion binding; nucleoside diphosphate kinase activity IPR001564; IPR023005; Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) (Nucleoside-2-P kinase) ndk Mflv_2633 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) TR32116_c2_g1_i1 Q86XW9 TXND6_HUMAN 4.00E-41 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0045454; GO:0005737; GO:0005856; GO:0004550 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; cell redox homeostasis; cytoplasm; cytoskeleton; nucleoside diphosphate kinase activity IPR001564; IPR012336; IPR017937; IPR013766; Thioredoxin domain-containing protein 6 (Thioredoxin-like protein 2) (Txl-2) NME9 TXL2 TXNDC6 Homo sapiens (Human) TR32116_c4_g1_i1 P90666 TXND3_ANTCR 2.00E-101 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0030154; GO:0045454; GO:0007275; GO:0004550; GO:0007283 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; cell differentiation; cell redox homeostasis; multicellular organismal development; nucleoside diphosphate kinase activity; spermatogenesis IPR001564; IPR023005; IPR012336; IPR017937; IPR013766; Thioredoxin domain-containing protein 3 homolog (Intermediate chain 1) (NME/NM23 family member 8) NME8 IC1 Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR32116_c4_g1_i2 Q95YJ5 TXND3_CIOIN 2.00E-97 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0030154; GO:0045454; GO:0007275; GO:0004550; GO:0007283 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; cell differentiation; cell redox homeostasis; multicellular organismal development; nucleoside diphosphate kinase activity; spermatogenesis IPR001564; IPR012336; IPR013766; Thioredoxin domain-containing protein 3 homolog (Dynein intermediate chain 3) CiIC3 Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) TR32116_c4_g1_i3 A7I3D2 NDK_CAMHC 4.00E-35 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0005737; GO:0046872; GO:0004550 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; cytoplasm; metal ion binding; nucleoside diphosphate kinase activity IPR001564; IPR023005; Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) (Nucleoside-2-P kinase) ndk CHAB381_1488 Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A) TR32117_c0_g1_i1 Q8N5N7 RM50_HUMAN 5.00E-12 GO:0005739; GO:0005840 mitochondrion; ribosome IPR018305; "39S ribosomal protein L50, mitochondrial (L50mt) (MRP-L50)" MRPL50 Homo sapiens (Human) TR32120_c0_g2_i5 Q70KH2 GLCM_PIG 4.00E-177 GO:0005975; GO:0004348; GO:0005765; GO:0006665 carbohydrate metabolic process; glucosylceramidase activity; lysosomal membrane; sphingolipid metabolic process IPR013780; IPR001139; IPR013781; IPR017853; Glucosylceramidase (EC 3.2.1.45) (Acid beta-glucosidase) (Beta-glucocerebrosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) GBA Sus scrofa (Pig) TR32126_c3_g3_i1 Q9P0K9 FRS1L_HUMAN 1.00E-10 GO:0030054; GO:0016021; GO:0005886; GO:0045202 cell junction; integral to membrane; plasma membrane; synapse IPR005018; DOMON domain-containing protein FRRS1L (Brain protein CG-6) (Ferric-chelate reductase 1-like protein) FRRS1L C9orf4 Homo sapiens (Human) TR32132_c5_g1_i1 Q68FD7 FNIP1_MOUSE 1.00E-46 GO:0031929; GO:0009267; GO:0005737; GO:0005085; GO:0002327; GO:0032007; GO:0043154; GO:0000122; GO:0002904; GO:0033138; GO:0001934; GO:2000973 Q8QZS3 TOR signaling cascade; cellular response to starvation; cytoplasm; guanyl-nucleotide exchange factor activity; immature B cell differentiation; negative regulation of TOR signaling cascade; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of B cell apoptotic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; regulation of pro-B cell differentiation IPR028086; IPR026156; IPR028085; IPR028084; Folliculin-interacting protein 1 Fnip1 Kiaa1961 Mus musculus (Mouse) TR32132_c5_g2_i1 Q5W4S4 FNIP1_CHICK 3.00E-63 GO:0031929; GO:0009267; GO:0005737; GO:0005085; GO:0002327; GO:0032007; GO:0043154; GO:0000122; GO:0002904; GO:0033138; GO:2000973 TOR signaling cascade; cellular response to starvation; cytoplasm; guanyl-nucleotide exchange factor activity; immature B cell differentiation; negative regulation of TOR signaling cascade; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of B cell apoptotic process; positive regulation of peptidyl-serine phosphorylation; regulation of pro-B cell differentiation IPR028086; IPR026156; IPR028085; IPR028084; Folliculin-interacting protein 1 FNIP1 Gallus gallus (Chicken) TR32133_c0_g2_i3 Q0VE82 CPNE7_MOUSE 1.00E-131 GO:0005886 plasma membrane IPR000008; IPR010734; IPR002035; Copine-7 (Copine VII) Cpne7 Mus musculus (Mouse) TR32134_c0_g1_i1 Q9CQE8 CN166_MOUSE 5.00E-73 GO:0000993; GO:0005815; GO:0005634; GO:0048471; GO:0045944; GO:0072669; GO:0006351 "RNA polymerase II core binding; microtubule organizing center; nucleus; perinuclear region of cytoplasm; positive regulation of transcription from RNA polymerase II promoter; tRNA-splicing ligase complex; transcription, DNA-dependent" IPR019265; UPF0568 protein C14orf166 homolog Mus musculus (Mouse) TR32135_c0_g1_i2 P68390 IOVO_MELGA 7.00E-12 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002350; IPR001239; Ovomucoid Meleagris gallopavo (Common turkey) TR32135_c0_g1_i3 P21674 FST_RAT 5.00E-10 GO:0048185; GO:0005576; GO:0002244; GO:0043395; GO:0032926; GO:0046882; GO:0000122; GO:0051798 P08476 activin binding; extracellular region; hematopoietic progenitor cell differentiation; heparan sulfate proteoglycan binding; negative regulation of activin receptor signaling pathway; negative regulation of follicle-stimulating hormone secretion; negative regulation of transcription from RNA polymerase II promoter; positive regulation of hair follicle development IPR003645; IPR015369; IPR002350; IPR017878; Follistatin (FS) (Activin-binding protein) Fst Rattus norvegicus (Rat) TR32135_c0_g1_i4 O96790 DPGN_DIPMA 7.00E-21 GO:0005576; GO:0050819; GO:0004867 extracellular region; negative regulation of coagulation; serine-type endopeptidase inhibitor activity IPR002350; Serine protease inhibitor dipetalogastin (Dipetalin) (Fragment) Dipetalogaster maximus (Blood-sucking bug) TR32135_c0_g1_i7 P82968 MCPI_MELCP 1.00E-16 GO:0004867 serine-type endopeptidase inhibitor activity IPR002350; IPR002223; IPR020901; Four-domain proteases inhibitor (McaPI) Melithaea caledonica TR32135_c0_g1_i8 P08479 IPSG_VULVU 5.00E-06 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002350; IPR001239; "Double-headed protease inhibitor, submandibular gland" Vulpes vulpes (Red fox) TR32135_c0_g1_i9 P08480 IPSG_FELCA 2.00E-08 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002350; IPR001239; "Double-headed protease inhibitor, submandibular gland" Felis catus (Cat) (Felis silvestris catus) TR32136_c2_g1_i1 Q3UJC8 CE034_MOUSE 8.00E-36 IPR027865; IPR027830; Uncharacterized protein C5orf34 homolog Mus musculus (Mouse) TR32138_c1_g1_i2 A8WHP3 SC5A9_DANRE 5.00E-117 GO:0016021; GO:0006814; GO:0055085; GO:0005215 integral to membrane; sodium ion transport; transmembrane transport; transporter activity IPR001734; IPR018212; IPR019900; Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (Solute carrier family 5 member 9) slc5a9 si:dkey-7o6.5 Danio rerio (Zebrafish) (Brachydanio rerio) TR32138_c1_g2_i1 P96169 SGLT_VIBPH 8.00E-27 GO:0008643; GO:0016021; GO:0005886; GO:0006814; GO:0015293 carbohydrate transport; integral to membrane; plasma membrane; sodium ion transport; symporter activity IPR001734; IPR018212; IPR019900; Sodium/glucose cotransporter (Na(+)/glucose symporter) sglT Vibrio parahaemolyticus TR32142_c2_g1_i1 Q8NB14 UBP38_HUMAN 2.00E-48 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.4.19.12) (Deubiquitinating enzyme 38) (HP43.8KD) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38) USP38 KIAA1891 Homo sapiens (Human) TR32142_c3_g1_i1 P38187 UBP13_YEAST 2.00E-18 GO:0010995; GO:0004221; GO:0006511; GO:0004843 free ubiquitin chain depolymerization; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13) UBP13 YBL067C YBL0621 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR32142_c3_g1_i2 Q96K76 UBP47_HUMAN 4.00E-12 GO:0019005; GO:0006284; GO:0034644; GO:0005737; GO:0035520; GO:0010972; GO:0043066; GO:0043154; GO:0045892; GO:0030307; GO:0042493; GO:0004221; GO:0006511; GO:0004843 "SCF ubiquitin ligase complex; base-excision repair; cellular response to UV; cytoplasm; monoubiquitinated protein deubiquitination; negative regulation of G2/M transition of mitotic cell cycle; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of transcription, DNA-dependent; positive regulation of cell growth; response to drug; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity" IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) USP47 Homo sapiens (Human) TR32144_c0_g1_i2 Q9W704 RIPA_XENLA 7.00E-46 GO:0046872; GO:0005634 metal ion binding; nucleus IPR028156; IPR028159; IPR028155; IPR028158; RPA-interacting protein A (RPA-interacting protein alpha) (XRIPalpha) rpain-a rip-a Xenopus laevis (African clawed frog) TR32145_c2_g1_i2 Q96JM7 LMBL3_HUMAN 1.00E-155 GO:0016568; GO:0005634; GO:0006355; GO:0006351 "chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR004092; IPR001660; IPR013761; IPR021129; Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (MBT-1) L3MBTL3 KIAA1798 MBT1 Homo sapiens (Human) TR32145_c2_g1_i3 O60284 ST18_HUMAN 4.00E-11 GO:0003677; GO:0005634; GO:0003700; GO:0006351; GO:0008270 "DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR013681; IPR002515; Suppression of tumorigenicity 18 protein (Zinc finger protein 387) ST18 KIAA0535 ZNF387 Homo sapiens (Human) TR32145_c2_g3_i1 Q9QWH1 PHC2_MOUSE 2.00E-16 GO:0003677; GO:0035102; GO:0031519; GO:0007275; GO:0007283; GO:0008270 P25916; P49137; P49138; P23798; Q64028; O35730; Q9CQJ4 DNA binding; PRC1 complex; PcG protein complex; multicellular organismal development; spermatogenesis; zinc ion binding IPR001660; IPR013761; IPR021129; IPR012313; Polyhomeotic-like protein 2 (mPH2) (Early development regulatory protein 2) (p36) Phc2 Edr2 Ph2 Mus musculus (Mouse) TR32146_c1_g1_i1 Q09429 ABCC8_RAT 8.00E-90 GO:0005524; GO:0006200; GO:0008282; GO:0042626; GO:0046676; GO:0043268; GO:0005267; GO:0042493; GO:0032868; GO:0032496; GO:0009268; GO:0010043; GO:0042383; GO:0008281; GO:0030672; GO:0019905 "ATP binding; ATP catabolic process; ATP-sensitive potassium channel complex; ATPase activity, coupled to transmembrane movement of substances; negative regulation of insulin secretion; positive regulation of potassium ion transport; potassium channel activity; response to drug; response to insulin stimulus; response to lipopolysaccharide; response to pH; response to zinc ion; sarcolemma; sulfonylurea receptor activity; synaptic vesicle membrane; syntaxin binding" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; IPR000388; IPR000844; ATP-binding cassette sub-family C member 8 (Sulfonylurea receptor 1) Abcc8 Sur Sur1 Rattus norvegicus (Rat) TR32147_c0_g1_i1 Q80Y44 DDX10_MOUSE 0 GO:0005524; GO:0008026; GO:0003723 ATP binding; ATP-dependent helicase activity; RNA binding IPR011545; IPR025313; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10) Ddx10 Mus musculus (Mouse) TR32149_c0_g1_i1 Q4JIJ2 MTRR_BOVIN 6.00E-24 GO:0010181; GO:0030586; GO:0005737; GO:0050660; GO:0005506; GO:0009086; GO:0016723 "FMN binding; [methionine synthase] reductase activity; cytoplasm; flavin adenine dinucleotide binding; iron ion binding; methionine biosynthetic process; oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor" IPR003097; IPR017927; IPR001094; IPR008254; IPR001709; IPR023173; IPR001433; IPR017938; Methionine synthase reductase (MSR) (EC 1.16.1.8) MTRR Bos taurus (Bovine) TR32149_c0_g2_i1 Q5BB41 TAH18_EMENI 5.00E-08 GO:0010181; GO:0005506; GO:0005739; GO:0016491 FMN binding; iron ion binding; mitochondrion; oxidoreductase activity IPR003097; IPR017927; IPR001094; IPR008254; IPR001709; IPR023173; IPR001433; IPR017938; NADPH-dependent diflavin oxidoreductase 1 (EC 1.6.-.-) (NADPH-dependent FMN and FAD-containing oxidoreductase) tah18 AN2239 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR32149_c2_g1_i1 P37039 NCPR_CAVPO 2.00E-09 GO:0010181; GO:0003958; GO:0005789; GO:0005506 FMN binding; NADPH-hemoprotein reductase activity; endoplasmic reticulum membrane; iron ion binding IPR003097; IPR017927; IPR001094; IPR008254; IPR001709; IPR023173; IPR001433; IPR023208; IPR017938; NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4) POR Cavia porcellus (Guinea pig) TR32149_c5_g1_i1 Q498R1 MTRR_RAT 1.00E-75 GO:0010181; GO:0030586; GO:0005829; GO:0050660; GO:0045111; GO:0005506; GO:0009086; GO:0005634; GO:0016709 "FMN binding; [methionine synthase] reductase activity; cytosol; flavin adenine dinucleotide binding; intermediate filament cytoskeleton; iron ion binding; methionine biosynthetic process; nucleus; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen" IPR003097; IPR017927; IPR001094; IPR008254; IPR001709; IPR023173; IPR001433; IPR017938; Methionine synthase reductase (MSR) (EC 1.16.1.8) Mtrr Rattus norvegicus (Rat) TR32149_c5_g1_i2 Q9UBK8 MTRR_HUMAN 3.00E-72 GO:0010181; GO:0050661; GO:0030586; GO:0034641; GO:0009235; GO:0005829; GO:0050660; GO:0045111; GO:0005506; GO:0009086; GO:0006555; GO:0032259; GO:0005634; GO:0016709; GO:0006805 "FMN binding; NADP binding; [methionine synthase] reductase activity; cellular nitrogen compound metabolic process; cobalamin metabolic process; cytosol; flavin adenine dinucleotide binding; intermediate filament cytoskeleton; iron ion binding; methionine biosynthetic process; methionine metabolic process; methylation; nucleus; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; xenobiotic metabolic process" IPR003097; IPR017927; IPR001094; IPR008254; IPR001709; IPR023173; IPR001433; IPR017938; Methionine synthase reductase (MSR) (EC 1.16.1.8) MTRR Homo sapiens (Human) TR32149_c5_g2_i1 Q17574 MTRR_CAEEL 2.00E-41 GO:0010181; GO:0030586; GO:0005829; GO:0005506; GO:0009086; GO:0016709 "FMN binding; [methionine synthase] reductase activity; cytosol; iron ion binding; methionine biosynthetic process; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen" IPR003097; IPR017927; IPR001094; IPR008254; IPR001709; IPR023173; IPR001433; IPR017938; Putative methionine synthase reductase (MSR) (EC 1.16.1.8) tag-165 C01G6.6 Caenorhabditis elegans TR32152_c0_g1_i1 O08564 LPP1_RAT 3.00E-64 GO:0016021; GO:0016020; GO:0008195; GO:0005886 integral to membrane; membrane; phosphatidate phosphatase activity; plasma membrane IPR000326; Lipid phosphate phosphohydrolase 1 (EC 3.1.3.4) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a) Ppap2a Lpp1 Rattus norvegicus (Rat) TR32152_c0_g1_i2 Q2HJ61 LPP2_BOVIN 3.00E-51 GO:0016021; GO:0008152; GO:0008195 integral to membrane; metabolic process; phosphatidate phosphatase activity IPR000326; Lipid phosphate phosphohydrolase 2 (EC 3.1.3.4) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid phosphatase 2c) (PAP-2c) (PAP2c) PPAP2C Bos taurus (Bovine) TR32154_c12_g1_i1 Q9U1S7 PKD2_CAEEL 2.00E-19 GO:0030424; GO:0005262; GO:0005509; GO:0060170; GO:0030425; GO:0050982; GO:0005783; GO:0005789; GO:0016021; GO:0043025; GO:0031513; GO:0043204; GO:0048471; GO:0034606; GO:0034608 axon; calcium channel activity; calcium ion binding; cilium membrane; dendrite; detection of mechanical stimulus; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; neuronal cell body; nonmotile primary cilium; perikaryon; perinuclear region of cytoplasm; response to hermaphrodite contact; vulval location IPR013122; IPR003915; Polycystin-2 (CePc2) (Polycystic kidney disease 2 protein homolog) pkd-2 Y73F8A.1 Caenorhabditis elegans TR32159_c2_g2_i6 O15164 TIF1A_HUMAN 7.00E-07 GO:0055074; GO:0071391; GO:0003682; GO:0005829; GO:0034056; GO:0070577; GO:0008285; GO:0045892; GO:0005719; GO:0005634; GO:0005726; GO:0045893; GO:0046777; GO:0030163; GO:0004672; GO:0005102; GO:0042981; GO:0031647; GO:0070562; GO:0043565; GO:0003713; GO:0006366; GO:0004842; GO:0008270 "calcium ion homeostasis; cellular response to estrogen stimulus; chromatin binding; cytosol; estrogen response element binding; histone acetyl-lysine binding; negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nucleus; perichromatin fibrils; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein catabolic process; protein kinase activity; receptor binding; regulation of apoptotic process; regulation of protein stability; regulation of vitamin D receptor signaling pathway; sequence-specific DNA binding; transcription coactivator activity; transcription from RNA polymerase II promoter; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR018359; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (Tripartite motif-containing protein 24) TRIM24 RNF82 TIF1 TIF1A Homo sapiens (Human) TR32160_c5_g1_i1 P35546 RET_MOUSE 7.00E-70 GO:0005524; GO:0000165; GO:0061146; GO:0005509; GO:0071300; GO:0001838; GO:0010008; GO:0048484; GO:0007156; GO:0005887; GO:0033619; GO:0001755; GO:0007158; GO:0042551; GO:0018108; GO:0033630; GO:0030335; GO:0045793; GO:2001241; GO:0072300; GO:0010976; GO:0045893; GO:0050770; GO:0048265; GO:0004714; GO:0007169; GO:0035799; GO:0001657 Q60629 "ATP binding; MAPK cascade; Peyer's patch morphogenesis; calcium ion binding; cellular response to retinoic acid; embryonic epithelial tube formation; endosome membrane; enteric nervous system development; homophilic cell adhesion; integral to plasma membrane; membrane protein proteolysis; neural crest cell migration; neuron cell-cell adhesion; neuron maturation; peptidyl-tyrosine phosphorylation; positive regulation of cell adhesion mediated by integrin; positive regulation of cell migration; positive regulation of cell size; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of metanephric glomerulus development; positive regulation of neuron projection development; positive regulation of transcription, DNA-dependent; regulation of axonogenesis; response to pain; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway; ureter maturation; ureteric bud development" IPR002126; IPR015919; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR016249; Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] Ret Mus musculus (Mouse) TR32163_c0_g1_i2 A4F4L4 DNAL4_PIG 1.00E-52 GO:0035085; GO:0030286; GO:0005874; GO:0007017; GO:0003774 cilium axoneme; dynein complex; microtubule; microtubule-based process; motor activity IPR001372; "Dynein light chain 4, axonemal" DNAL4 Sus scrofa (Pig) TR32166_c2_g1_i1 Q96JH7 VCIP1_HUMAN 5.00E-23 GO:0090168; GO:0005795; GO:0005737; GO:0005783; GO:0016320; GO:0007067; GO:0035871; GO:0071108; GO:0016567; GO:0006508; GO:0004843 Golgi reassembly; Golgi stack; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane fusion; mitosis; protein K11-linked deubiquitination; protein K48-linked deubiquitination; protein ubiquitination; proteolysis; ubiquitin-specific protease activity IPR003323; Deubiquitinating protein VCIP135 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) VCPIP1 KIAA1850 VCIP135 Homo sapiens (Human) TR32166_c2_g1_i2 Q8CDG3 VCIP1_MOUSE 5.00E-23 GO:0090168; GO:0005795; GO:0005783; GO:0016320; GO:0007067; GO:0035871; GO:0071108; GO:0016567; GO:0006508; GO:0004843 Golgi reassembly; Golgi stack; endoplasmic reticulum; endoplasmic reticulum membrane fusion; mitosis; protein K11-linked deubiquitination; protein K48-linked deubiquitination; protein ubiquitination; proteolysis; ubiquitin-specific protease activity IPR003323; Deubiquitinating protein VCIP135 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) Vcpip1 Vcip135 Mus musculus (Mouse) TR32167_c1_g2_i1 Q6ZSM3 MOT12_HUMAN 4.00E-44 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) SLC16A12 MCT12 Homo sapiens (Human) TR32168_c3_g1_i1 Q6IV56 RN141_DANRE 3.00E-41 GO:0008270 zinc ion binding IPR001841; IPR013083; IPR017907; RING finger protein 141 rnf141 zgc:86917 Danio rerio (Zebrafish) (Brachydanio rerio) TR32169_c0_g1_i1 Q6TEK3 VKORL_RAT 1.00E-40 GO:0016021 integral to membrane IPR012932; Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1-like protein 1) Vkorc1l1 Rattus norvegicus (Rat) TR3217_c0_g1_i1 P0C7W6 CC172_HUMAN 5.00E-07 Coiled-coil domain-containing protein 172 CCDC172 C10orf96 Homo sapiens (Human) TR32170_c3_g1_i2 O50655 XERD_SELRU 2.00E-10 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR32171_c1_g1_i1 Q9CXF4 TBC15_MOUSE 6.00E-176 GO:0005097; GO:0005576; GO:0005739 Rab GTPase activator activity; extracellular region; mitochondrion IPR021935; IPR000195; TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP) Tbc1d15 Mus musculus (Mouse) TR32172_c0_g1_i4 P28021 CSK2B_XENLA 1.00E-135 GO:0016055; GO:0046872; GO:0005956; GO:0019887; GO:0045859 B5TR11 Wnt receptor signaling pathway; metal ion binding; protein kinase CK2 complex; protein kinase regulator activity; regulation of protein kinase activity IPR016149; IPR016150; IPR000704; Casein kinase II subunit beta (CK II beta) (Phosvitin) csnk2b Xenopus laevis (African clawed frog) TR32175_c0_g1_i1 Q3UQ28 PXDN_MOUSE 2.00E-09 GO:0005783; GO:0031012; GO:0030198; GO:0005201; GO:0005615; GO:0020037; GO:0042744; GO:0046872; GO:0004601; GO:0005578 endoplasmic reticulum; extracellular matrix; extracellular matrix organization; extracellular matrix structural constituent; extracellular space; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity; proteinaceous extracellular matrix IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; IPR001007; Peroxidasin homolog (EC 1.11.1.7) Pxdn Kiaa0230 Mus musculus (Mouse) TR32175_c0_g3_i1 Q9I8C7 ACH10_CHICK 2.00E-13 GO:0004889; GO:0005262; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; calcium channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 Gallus gallus (Chicken) TR32175_c0_g3_i3 Q5IS75 ACHB3_PANTR 4.00E-12 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit beta-3 CHRNB3 Pan troglodytes (Chimpanzee) TR32175_c0_g3_i6 O15394 NCAM2_HUMAN 4.00E-07 GO:0030424; GO:0016021; GO:0007158; GO:0005886 axon; integral to membrane; neuron cell-cell adhesion; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR009138; Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2) NCAM2 NCAM21 Homo sapiens (Human) TR32176_c0_g1_i1 O07552 NHAX_BACSU 9.00E-06 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Stress response protein NhaX nhaX yheK BSU09690 Bacillus subtilis (strain 168) TR32177_c0_g1_i1 Q9Y6C2 EMIL1_HUMAN 3.00E-06 GO:0007155; GO:0005581; GO:0030023; GO:0030198; GO:0070062; GO:0010811 cell adhesion; collagen; extracellular matrix constituent conferring elasticity; extracellular matrix organization; extracellular vesicular exosome; positive regulation of cell-substrate adhesion IPR001073; IPR008160; IPR011489; IPR008983; EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1) EMILIN1 EMI Homo sapiens (Human) TR32177_c0_g2_i1 Q9ES30 C1QT3_MOUSE 5.00E-09 GO:0005581; GO:0005615; GO:0042593; GO:0042802; GO:0045721; GO:0070374; GO:0070165; GO:0050715; GO:0051897; GO:0051259 collagen; extracellular space; glucose homeostasis; identical protein binding; negative regulation of gluconeogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of adiponectin secretion; positive regulation of cytokine secretion; positive regulation of protein kinase B signaling cascade; protein oligomerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1qtnf3 Cors26 Ctrp3 Mus musculus (Mouse) TR32177_c11_g1_i1 O01705 EXT2_CAEEL 2.00E-117 GO:0048598; GO:0050508; GO:0001888; GO:0042328; GO:0015012; GO:0016021; GO:0031227; GO:0060465 embryonic morphogenesis; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; heparan sulfate N-acetylglucosaminyltransferase activity; heparan sulfate proteoglycan biosynthetic process; integral to membrane; intrinsic to endoplasmic reticulum membrane; pharynx development IPR027674; IPR004263; IPR015338; Glycan metabolism; heparan sulfate biosynthesis. Exostosin-2 (EC 2.4.1.223) (EC 2.4.1.224) (Glucuronyl-galactosyl-proteoglycan/Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses homolog 2) rib-2 K01G5.6 Caenorhabditis elegans TR32177_c11_g1_i2 O43909 EXTL3_HUMAN 6.00E-178 GO:0006987; GO:0044267; GO:0005789; GO:0001888; GO:0015012; GO:0016021; GO:0031227; GO:0046872; GO:0030307 activation of signaling protein activity involved in unfolded protein response; cellular protein metabolic process; endoplasmic reticulum membrane; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; heparan sulfate proteoglycan biosynthetic process; integral to membrane; intrinsic to endoplasmic reticulum membrane; metal ion binding; positive regulation of cell growth IPR027674; IPR004263; IPR015338; Glycan metabolism; heparan sulfate biosynthesis. Exostosin-like 3 (EC 2.4.1.223) (EXT-related protein 1) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Hereditary multiple exostoses gene isolog) (Multiple exostosis-like protein 3) (Putative tumor suppressor protein EXTL3) EXTL3 EXTL1L EXTR1 KIAA0519 Homo sapiens (Human) TR32177_c11_g1_i4 O43909 EXTL3_HUMAN 1.00E-177 GO:0006987; GO:0044267; GO:0005789; GO:0001888; GO:0015012; GO:0016021; GO:0031227; GO:0046872; GO:0030307 activation of signaling protein activity involved in unfolded protein response; cellular protein metabolic process; endoplasmic reticulum membrane; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; heparan sulfate proteoglycan biosynthetic process; integral to membrane; intrinsic to endoplasmic reticulum membrane; metal ion binding; positive regulation of cell growth IPR027674; IPR004263; IPR015338; Glycan metabolism; heparan sulfate biosynthesis. Exostosin-like 3 (EC 2.4.1.223) (EXT-related protein 1) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Hereditary multiple exostoses gene isolog) (Multiple exostosis-like protein 3) (Putative tumor suppressor protein EXTL3) EXTL3 EXTL1L EXTR1 KIAA0519 Homo sapiens (Human) TR32177_c4_g2_i1 O43909 EXTL3_HUMAN 4.00E-12 GO:0006987; GO:0044267; GO:0005789; GO:0001888; GO:0015012; GO:0016021; GO:0031227; GO:0046872; GO:0030307 activation of signaling protein activity involved in unfolded protein response; cellular protein metabolic process; endoplasmic reticulum membrane; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; heparan sulfate proteoglycan biosynthetic process; integral to membrane; intrinsic to endoplasmic reticulum membrane; metal ion binding; positive regulation of cell growth IPR027674; IPR004263; IPR015338; Glycan metabolism; heparan sulfate biosynthesis. Exostosin-like 3 (EC 2.4.1.223) (EXT-related protein 1) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Hereditary multiple exostoses gene isolog) (Multiple exostosis-like protein 3) (Putative tumor suppressor protein EXTL3) EXTL3 EXTL1L EXTR1 KIAA0519 Homo sapiens (Human) TR32177_c4_g3_i1 Q9XZ08 EXT3_DROME 2.00E-09 GO:0005794; GO:0000139; GO:0006044; GO:0016055; GO:0008101; GO:0005783; GO:0001888; GO:0015014; GO:0030210; GO:0016021; GO:0031227; GO:0007275; GO:0007224 "Golgi apparatus; Golgi membrane; N-acetylglucosamine metabolic process; Wnt receptor signaling pathway; decapentaplegic signaling pathway; endoplasmic reticulum; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; heparin biosynthetic process; integral to membrane; intrinsic to endoplasmic reticulum membrane; multicellular organismal development; smoothened signaling pathway" IPR027674; IPR004263; IPR015338; Glycan metabolism; heparan sulfate biosynthesis. Exostosin-3 (EC 2.4.1.223) (Protein brother of tout-velu) botv DEXT3 CG15110 Drosophila melanogaster (Fruit fly) TR32177_c8_g1_i2 O01704 EXT1_CAEEL 1.00E-12 GO:0005783; GO:0015012; GO:0060465 endoplasmic reticulum; heparan sulfate proteoglycan biosynthetic process; pharynx development IPR004263; IPR027670; Multiple exostoses homolog 1 (Related to mammalian RIB protein 1) rib-1 F12F6.3 Caenorhabditis elegans TR32180_c1_g1_i1 Q8CFR0 C1QL2_MOUSE 1.00E-06 GO:0005581; GO:0005576; GO:0042802; GO:0051259 collagen; extracellular region; identical protein binding; protein oligomerization IPR001073; IPR008160; IPR008983; Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) (C1qTNF10) (CTRP10) C1ql2 C1qtnf10 Ctrp10 Mus musculus (Mouse) TR32180_c1_g1_i2 Q4ZJM9 C1QL4_MOUSE 3.00E-07 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) TR32180_c1_g1_i3 P83425 HIP_MYTED 8.00E-06 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR32181_c10_g1_i1 Q8BNA6 FAT3_MOUSE 8.00E-18 GO:0005509; GO:0007156; GO:0016021; GO:0007275; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; multicellular organismal development; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Protocadherin Fat 3 (FAT tumor suppressor homolog 3) Fat3 Gm1132 Gm510 Mus musculus (Mouse) TR32181_c6_g1_i2 Q0V8T4 CTP5C_RAT 2.00E-08 GO:0007155; GO:0016021 cell adhesion; integral to membrane IPR000421; IPR008985; IPR013320; IPR000742; IPR002181; IPR008979; IPR001791; Contactin-associated protein like 5-3 (Cell recognition molecule Caspr5-3) (Cell recognition molecule Caspr5c) (Contactin-associated protein-like 5c) Cntnap5c Caspr5-3 Rattus norvegicus (Rat) TR32181_c6_g1_i4 Q2PZL6 FAT4_MOUSE 3.00E-22 GO:0045177; GO:0001658; GO:0005509; GO:0048565; GO:0001736; GO:0003007; GO:0007156; GO:0060122; GO:0016021; GO:0001822; GO:0043931; GO:0005886; GO:0007009 apical part of cell; branching involved in ureteric bud morphogenesis; calcium ion binding; digestive tract development; establishment of planar polarity; heart morphogenesis; homophilic cell adhesion; inner ear receptor stereocilium organization; integral to membrane; kidney development; ossification involved in bone maturation; plasma membrane; plasma membrane organization IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) Fat4 Fatj Mus musculus (Mouse) TR32183_c0_g1_i1 Q8BL97 SRSF7_MOUSE 4.00E-09 GO:0003723; GO:0008380; GO:0006397; GO:0048025; GO:0000166; GO:0005634; GO:0008270 Q6PFR5 "RNA binding; RNA splicing; mRNA processing; negative regulation of mRNA splicing, via spliceosome; nucleotide binding; nucleus; zinc ion binding" IPR012677; IPR000504; IPR001878; "Serine/arginine-rich splicing factor 7 (Splicing factor, arginine/serine-rich 7)" Srsf7 Sfrs7 Mus musculus (Mouse) TR32183_c0_g1_i2 Q6DJI9 ZCRB1_XENLA 1.00E-58 GO:0003723; GO:0008380; GO:0006397; GO:0000166; GO:0005681; GO:0008270 RNA binding; RNA splicing; mRNA processing; nucleotide binding; spliceosomal complex; zinc ion binding IPR012677; IPR000504; IPR001878; Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (U11/U12 small nuclear ribonucleoprotein 31 kDa protein) (U11/U12 snRNP 31 kDa protein) zcrb1 Xenopus laevis (African clawed frog) TR32185_c2_g1_i2 Q3SZ19 PSMD9_BOVIN 9.00E-39 GO:0070682 proteasome regulatory particle assembly IPR001478; 26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27) PSMD9 Bos taurus (Bovine) TR32187_c0_g1_i2 Q9H4K1 RIBC2_HUMAN 1.00E-63 IPR008805; RIB43A-like with coiled-coils protein 2 RIBC2 C22orf11 Homo sapiens (Human) TR32188_c0_g1_i1 Q8K2J9 BTBD6_MOUSE 7.00E-43 GO:0000932 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6 Btbd6 Mus musculus (Mouse) TR32189_c0_g1_i1 O93567 ZBT7A_CHICK 2.00E-11 GO:0003677; GO:0046872; GO:0045892; GO:0005634; GO:0006351 "DNA binding; metal ion binding; negative regulation of transcription, DNA-dependent; nucleus; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma-related factor) (cLRF) ZBTB7A LRF ZBTB7 Gallus gallus (Chicken) TR32189_c0_g2_i1 Q6Q7X9 KLH31_DANRE 1.00E-72 IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; IPR011498; Kelch-like protein 31 (Kelch repeat and BTB domain-containing protein 1) (Kelch-like protein Klhl) klhl31 kbtbd1 klhl Danio rerio (Zebrafish) (Brachydanio rerio) TR32189_c0_g2_i2 Q6ZPT1 KLHL9_MOUSE 3.00E-72 GO:0031463; GO:0000910; GO:0030496; GO:0007067; GO:0016567; GO:0004842 Cul3-RING ubiquitin ligase complex; cytokinesis; midbody; mitosis; protein ubiquitination; ubiquitin-protein ligase activity IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 9 Klhl9 Kiaa1354 Mus musculus (Mouse) TR32193_c2_g1_i1 Q6P988 NOTUM_HUMAN 2.00E-22 GO:0005576; GO:0016787 extracellular region; hydrolase activity IPR004963; Protein notum homolog (EC 3.-.-.-) NOTUM OK/SW-CL.30 Homo sapiens (Human) TR32194_c2_g1_i3 Q90YQ0 RS24_ICTPU 5.00E-36 GO:0000166; GO:0005840; GO:0003735; GO:0006412 nucleotide binding; ribosome; structural constituent of ribosome; translation IPR012677; IPR012678; IPR001976; IPR018098; 40S ribosomal protein S24 rps24 Ictalurus punctatus (Channel catfish) (Silurus punctatus) TR32195_c2_g2_i2 Q9JJG6 TMM47_MOUSE 5.00E-09 GO:0005911; GO:0016021; GO:0005886 cell-cell junction; integral to membrane; plasma membrane IPR015664; IPR004031; Transmembrane protein 47 (Transmembrane 4 superfamily member 10) Tmem47 Tm4sf10 MNCb-0941 Mus musculus (Mouse) TR32196_c1_g2_i1 Q9UU99 YJX4_SCHPO 1.00E-08 GO:0006696; GO:0008526; GO:0005886 ergosterol biosynthetic process; phosphatidylinositol transporter activity; plasma membrane IPR001251; IPR011074; CRAL-TRIO domain-containing protein C23B6.04c SPCC23B6.04c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR32197_c0_g3_i1 Q9V4M2 WECH_DROME 2.00E-06 GO:0030154; GO:0002168; GO:0005622; GO:0016203; GO:0005927; GO:0033632; GO:0008270 cell differentiation; instar larval development; intracellular; muscle attachment; muscle tendon junction; regulation of cell-cell adhesion mediated by integrin; zinc ion binding IPR011042; IPR001258; IPR013017; IPR000315; Protein wech (Protein dappled) wech dpld CG42396 Drosophila melanogaster (Fruit fly) TR32199_c4_g1_i1 Q29RV0 CDN2D_BOVIN 5.00E-11 GO:0000731; GO:0000082; GO:0048102; GO:0007050; GO:0004861; GO:0005737; GO:0030308; GO:0008285; GO:0043154; GO:1902230; GO:0005634; GO:0000079; GO:0009411; GO:0032526; GO:0033280; GO:0007605 DNA synthesis involved in DNA repair; G1/S transition of mitotic cell cycle; autophagic cell death; cell cycle arrest; cyclin-dependent protein serine/threonine kinase inhibitor activity; cytoplasm; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; nucleus; regulation of cyclin-dependent protein serine/threonine kinase activity; response to UV; response to retinoic acid; response to vitamin D; sensory perception of sound IPR002110; IPR020683; Cyclin-dependent kinase 4 inhibitor D (p19-INK4d) CDKN2D Bos taurus (Bovine) TR32199_c4_g1_i2 Q5UPG5 YL093_MIMIV 2.00E-31 IPR002110; IPR020683; Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) TR32199_c4_g1_i3 Q54GC8 ACBD6_DICDI 1.00E-06 GO:0005737; GO:0000062; GO:0008289 cytoplasm; fatty-acyl-CoA binding; lipid binding IPR000582; IPR002110; IPR020683; IPR014352; Acyl-CoA-binding domain-containing protein 6 homolog acbd6 DDB_G0290237 Dictyostelium discoideum (Slime mold) TR32199_c4_g1_i4 Q99J82 ILK_RAT 3.00E-16 GO:0005524; GO:0017124; GO:0007569; GO:0007050; GO:0005911; GO:0043034; GO:0043198; GO:0043206; GO:0005925; GO:0007229; GO:0030027; GO:0032288; GO:0010667; GO:0043524; GO:0006469; GO:0014912; GO:0048662; GO:0048812; GO:0043025; GO:0018105; GO:0005886; GO:0030513; GO:0043406; GO:0045773; GO:0090263; GO:0030335; GO:0008284; GO:0001954; GO:0050775; GO:0045663; GO:0045669; GO:0051897; GO:0045893; GO:0043234; GO:0051291; GO:0004674; GO:0032956; GO:0030017; GO:0004871; GO:0034446; GO:0043195 "ATP binding; SH3 domain binding; cell aging; cell cycle arrest; cell-cell junction; costamere; dendritic shaft; extracellular fibril organization; focal adhesion; integrin-mediated signaling pathway; lamellipodium; myelin assembly; negative regulation of cardiac muscle cell apoptotic process; negative regulation of neuron apoptotic process; negative regulation of protein kinase activity; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; neuron projection morphogenesis; neuronal cell body; peptidyl-serine phosphorylation; plasma membrane; positive regulation of BMP signaling pathway; positive regulation of MAP kinase activity; positive regulation of axon extension; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of dendrite morphogenesis; positive regulation of myoblast differentiation; positive regulation of osteoblast differentiation; positive regulation of protein kinase B signaling cascade; positive regulation of transcription, DNA-dependent; protein complex; protein heterooligomerization; protein serine/threonine kinase activity; regulation of actin cytoskeleton organization; sarcomere; signal transducer activity; substrate adhesion-dependent cell spreading; terminal bouton" IPR002110; IPR020683; IPR016253; IPR011009; IPR000719; IPR001245; Integrin-linked protein kinase (EC 2.7.11.1) Ilk Rattus norvegicus (Rat) TR32199_c4_g1_i5 Q54HW1 PSD10_DICDI 5.00E-17 IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) psmD10 DDB_G0289189 Dictyostelium discoideum (Slime mold) TR32199_c4_g1_i6 Q1LZC5 ANR54_BOVIN 6.00E-13 GO:0007049; GO:0005737; GO:0030496; GO:0006913; GO:0005634; GO:0045648; GO:0019887; GO:0010627 cell cycle; cytoplasm; midbody; nucleocytoplasmic transport; nucleus; positive regulation of erythrocyte differentiation; protein kinase regulator activity; regulation of intracellular protein kinase cascade IPR002110; IPR020683; Ankyrin repeat domain-containing protein 54 ANKRD54 Bos taurus (Bovine) TR32199_c4_g1_i7 Q9D119 PPR27_MOUSE 7.00E-07 GO:0010923; GO:0019902; GO:0004864 negative regulation of phosphatase activity; phosphatase binding; protein phosphatase inhibitor activity IPR002110; IPR020683; Protein phosphatase 1 regulatory subunit 27 (Dysferlin-interacting protein 1) Ppp1r27 Dysfip1 Mus musculus (Mouse) TR32199_c4_g2_i2 P18954 PHLB_SERLI 2.00E-07 IPR002110; IPR020683; Protein PhlB phlB Serratia liquefaciens TR32199_c4_g3_i3 Q9N3Q8 DAF25_CAEEL 7.00E-09 GO:0043054; GO:0046872; GO:0061067; GO:0031513; GO:0010753; GO:0033365; GO:0050920; GO:0046662; GO:0006970 dauer exit; metal ion binding; negative regulation of dauer larval development; nonmotile primary cilium; positive regulation of cGMP-mediated signaling; protein localization to organelle; regulation of chemotaxis; regulation of oviposition; response to osmotic stress IPR002110; IPR020683; IPR002893; Dauer abnormal formation protein 25 (daf-25) (suppressor of che-2 small body size 3) (Chb-3) daf-25 Y48G1A.3 Caenorhabditis elegans TR32199_c4_g5_i1 Q9C0D5 TANC1_HUMAN 2.00E-27 GO:0043679; GO:0030054; GO:0030425; GO:0097062; GO:0007520; GO:0043025; GO:0014069; GO:0045211; GO:0008542 axon terminus; cell junction; dendrite; dendritic spine maintenance; myoblast fusion; neuronal cell body; postsynaptic density; postsynaptic membrane; visual learning IPR002110; IPR020683; IPR027417; IPR013026; IPR011990; IPR013105; IPR019734; "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" TANC1 KIAA1728 Homo sapiens (Human) TR32199_c4_g5_i2 Q5UPG5 YL093_MIMIV 2.00E-44 IPR002110; IPR020683; Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) TR32199_c4_g6_i1 Q9J5H9 V022_FOWPN 2.00E-09 IPR002110; IPR020683; IPR018272; Putative ankyrin repeat protein FPV022 FPV022 Fowlpox virus (strain NVSL) (FPV) TR32199_c4_g7_i2 Q9VSA4 TONSL_DROME 3.00E-13 IPR002110; IPR020683; IPR013026; IPR011990; IPR019734; Tonsoku-like protein CG7457 Drosophila melanogaster (Fruit fly) TR32199_c4_g7_i4 O88202 LPP60_RAT 6.00E-06 GO:0003847; GO:0004067; GO:0006528; GO:0016042; GO:0004622; GO:0006644 1-alkyl-2-acetylglycerophosphocholine esterase activity; asparaginase activity; asparagine metabolic process; lipid catabolic process; lysophospholipase activity; phospholipid metabolic process IPR002110; IPR020683; IPR006033; IPR006034; IPR027475; IPR027473; IPR027474; 60 kDa lysophospholipase (EC 3.1.1.5) [Includes: L-asparaginase (EC 3.5.1.1) (L-asparagine amidohydrolase); Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47)] Aspg Rattus norvegicus (Rat) TR32199_c5_g1_i1 F1M5M3 TEX14_RAT 1.00E-06 GO:0005524; GO:0008608; GO:0051301; GO:0000777; GO:0005737; GO:0045171; GO:0043063; GO:0000776; GO:0007140; GO:0030496; GO:0051306; GO:0007094; GO:0004672 ATP binding; attachment of spindle microtubules to kinetochore; cell division; condensed chromosome kinetochore; cytoplasm; intercellular bridge; intercellular bridge organization; kinetochore; male meiosis; midbody; mitotic sister chromatid separation; mitotic spindle assembly checkpoint; protein kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR001245; Inactive serine/threonine-protein kinase TEX14 (Testis-expressed sequence 14) (Testis-expressed sequence 14 protein) Tex14 Rattus norvegicus (Rat) TR3220_c0_g1_i1 O43715 TRIA1_HUMAN 1.00E-17 GO:0006977; GO:0034644; GO:0043027; GO:0005739; GO:1902166; GO:0048471; GO:0045944 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; cellular response to UV; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; mitochondrion; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; perinuclear region of cytoplasm; positive regulation of transcription from RNA polymerase II promoter" IPR007918; TP53-regulated inhibitor of apoptosis 1 (Protein 15E1.1) (WF-1) (p53-inducible cell-survival factor) (p53CSV) TRIAP1 15E1.1 HSPC132 Homo sapiens (Human) TR32200_c2_g1_i2 O02466 ILPR_BRALA 5.00E-06 GO:0005524; GO:0016021; GO:0046872; GO:0018108; GO:0046777; GO:0004714; GO:0007169 ATP binding; integral to membrane; metal ion binding; peptidyl-tyrosine phosphorylation; protein autophosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000494; IPR003961; IPR006211; IPR006212; IPR009030; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR016246; IPR002011; Insulin-like peptide receptor (ILP receptor) (EC 2.7.10.1) [Cleaved into: Insulin-like peptide receptor alpha chain; Insulin-like peptide receptor beta chain] Branchiostoma lanceolatum (Common lancelet) (Amphioxus) TR32202_c2_g1_i1 Q9NQG1 MANBL_HUMAN 1.00E-07 GO:0016021 integral to membrane IPR009621; Protein MANBAL MANBAL Homo sapiens (Human) TR32204_c0_g1_i1 P74148 Y1388_SYNY3 2.00E-07 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein Sll1388 (USP Sll1388) sll1388 Synechocystis sp. (strain PCC 6803 / Kazusa) TR32204_c0_g2_i1 Q8LGG8 USPAL_ARATH 7.00E-08 GO:0005886; GO:0006950 plasma membrane; response to stress IPR014729; IPR006015; IPR006016; Universal stress protein A-like protein At3g01520 F4P13.7 Arabidopsis thaliana (Mouse-ear cress) TR32207_c0_g1_i1 Q5F3X0 LCLT1_CHICK 3.00E-08 GO:0003841; GO:0016024; GO:0005789; GO:0016021; GO:0007275 1-acylglycerol-3-phosphate O-acyltransferase activity; CDP-diacylglycerol biosynthetic process; endoplasmic reticulum membrane; integral to membrane; multicellular organismal development IPR002123; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. Lysocardiolipin acyltransferase 1 (EC 2.3.1.-) (EC 2.3.1.51) LCLAT1 LYCAT RCJMB04_5b22 Gallus gallus (Chicken) TR32207_c0_g1_i2 Q6NYV8 LCLT1_DANRE 8.00E-07 GO:0003841; GO:0016024; GO:0005789; GO:0001885; GO:0060217; GO:0016021 1-acylglycerol-3-phosphate O-acyltransferase activity; CDP-diacylglycerol biosynthetic process; endoplasmic reticulum membrane; endothelial cell development; hemangioblast cell differentiation; integral to membrane IPR002123; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. Lysocardiolipin acyltransferase 1 (EC 2.3.1.-) (EC 2.3.1.51) lclat1 lycat zgc:77380 Danio rerio (Zebrafish) (Brachydanio rerio) TR32207_c1_g1_i2 Q91YX5 LGAT1_MOUSE 3.00E-37 GO:0005789; GO:0016021; GO:0008654; GO:0016746 "endoplasmic reticulum membrane; integral to membrane; phospholipid biosynthetic process; transferase activity, transferring acyl groups" IPR002123; Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (EC 2.3.1.-) Lpgat1 Fam34a Mus musculus (Mouse) TR32208_c0_g1_i1 Q91754 GCKR_XENLA 6.00E-08 GO:0030246; GO:0005975; GO:0005737; GO:0070095; GO:0033132; GO:0005654 carbohydrate binding; carbohydrate metabolic process; cytoplasm; fructose-6-phosphate binding; negative regulation of glucokinase activity; nucleoplasm IPR005486; IPR001347; Glucokinase regulatory protein (Glucokinase regulator) gckr Xenopus laevis (African clawed frog) TR32208_c1_g1_i1 Q91754 GCKR_XENLA 1.00E-130 GO:0030246; GO:0005975; GO:0005737; GO:0070095; GO:0033132; GO:0005654 carbohydrate binding; carbohydrate metabolic process; cytoplasm; fructose-6-phosphate binding; negative regulation of glucokinase activity; nucleoplasm IPR005486; IPR001347; Glucokinase regulatory protein (Glucokinase regulator) gckr Xenopus laevis (African clawed frog) TR32212_c0_g1_i2 P0CG11 CTF8_BOVIN 3.00E-39 GO:0003677; GO:0006260; GO:0007049; GO:0005634 DNA binding; DNA replication; cell cycle; nucleus IPR018607; Chromosome transmission fidelity protein 8 homolog CHTF8 CTF8 Bos taurus (Bovine) TR32212_c0_g1_i3 P0C6T1 CTF8_RAT 4.00E-37 GO:0003677; GO:0006260; GO:0007049; GO:0005634 DNA binding; DNA replication; cell cycle; nucleus IPR018607; Chromosome transmission fidelity protein 8 homolog Chtf8 Ctf8 Rattus norvegicus (Rat) TR32215_c4_g1_i1 Q3B8G0 CA123_XENLA 3.00E-68 IPR008584; UPF0587 protein C1orf123 homolog Xenopus laevis (African clawed frog) TR32217_c0_g1_i1 Q8IUM7 NPAS4_HUMAN 4.00E-49 GO:0003677; GO:0005634; GO:0045944; GO:0004871; GO:0005667; GO:0006351 "DNA binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; signal transducer activity; transcription factor complex; transcription, DNA-dependent" IPR011598; IPR000014; IPR013655; Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (Class E basic helix-loop-helix protein 79) (bHLHe79) (HLH-PAS transcription factor NXF) (PAS domain-containing protein 10) NPAS4 BHLHE79 NXF PASD10 Homo sapiens (Human) TR32217_c0_g1_i2 Q8CJH6 NPAS4_RAT 4.00E-49 GO:0003677; GO:0005634; GO:0045944; GO:0046982; GO:0004871; GO:0005667; GO:0006351 "DNA binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; signal transducer activity; transcription factor complex; transcription, DNA-dependent" IPR011598; IPR000014; IPR013655; Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) Npas4 Nxf Rattus norvegicus (Rat) TR32217_c0_g1_i3 P35869 AHR_HUMAN 9.00E-17 GO:0051879; GO:0003705; GO:0006915; GO:0001568; GO:0007049; GO:0034752; GO:0004879; GO:0000122; GO:0005634; GO:0045899; GO:0030850; GO:0046982; GO:0030888; GO:0006950; GO:0043565; GO:0005667; GO:0044212; GO:0006805 P27540; P12977; Q8NI08; Q9Y618 Hsp90 protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; apoptotic process; blood vessel development; cell cycle; cytosolic aryl hydrocarbon receptor complex; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; prostate gland development; protein heterodimerization activity; regulation of B cell proliferation; response to stress; sequence-specific DNA binding; transcription factor complex; transcription regulatory region DNA binding; xenobiotic metabolic process IPR011598; IPR001610; IPR000014; IPR013767; IPR013655; Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76) AHR BHLHE76 Homo sapiens (Human) TR32218_c1_g1_i1 Q61425 HCDH_MOUSE 7.00E-142 GO:0003857; GO:0070403; GO:0006635; GO:0005743; GO:0005759; GO:0046676; GO:0014823; GO:0042493; GO:0032868 3-hydroxyacyl-CoA dehydrogenase activity; NAD+ binding; fatty acid beta-oxidation; mitochondrial inner membrane; mitochondrial matrix; negative regulation of insulin secretion; response to activity; response to drug; response to insulin stimulus IPR022694; IPR006180; IPR006176; IPR006108; IPR008927; IPR013328; IPR016040; Lipid metabolism; fatty acid beta-oxidation. "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase)" Hadh Hadhsc Mschad Schad Mus musculus (Mouse) TR32219_c3_g1_i1 A3KGT9 GPT3L_DANRE 4.00E-99 GO:0003841; GO:0016024; GO:0005789; GO:0004366; GO:0016021; GO:0019432 1-acylglycerol-3-phosphate O-acyltransferase activity; CDP-diacylglycerol biosynthetic process; endoplasmic reticulum membrane; glycerol-3-phosphate O-acyltransferase activity; integral to membrane; triglyceride biosynthetic process IPR002123; Glycerolipid metabolism; triacylglycerol biosynthesis. Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. Glycerol-3-phosphate acyltransferase 3-like (EC 2.3.1.15) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9-like) (1-AGP acyltransferase 9-like) (1-AGPAT 9-like) (EC 2.3.1.51) (Lysophosphatidic acid acyltransferase theta-like) (LPAAT-theta-like) agpat9l si:ch211-155m12.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR3222_c1_g1_i1 Q22851 ASIC2_CAEEL 8.00E-09 GO:0016021; GO:0005272; GO:0035725 integral to membrane; sodium channel activity; sodium ion transmembrane transport IPR001873; IPR020903; Degenerin-like protein asic-2 (Acid-sensing/amiloride-sensitive ion channel protein 2) asic-2 T28F4.2 Caenorhabditis elegans TR32220_c1_g1_i3 Q9WVB4 SLIT3_MOUSE 6.00E-15 GO:0035385; GO:0061364; GO:0048846; GO:0007411; GO:0005509; GO:0032870; GO:0005615; GO:0050919; GO:0030308; GO:0008285; GO:0070100; GO:0010629; GO:0009887; GO:0005102; GO:0051414 Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; axon guidance; calcium ion binding; cellular response to hormone stimulus; extracellular space; negative chemotaxis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of chemokine-mediated signaling pathway; negative regulation of gene expression; organ morphogenesis; receptor binding; response to cortisol stimulus IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 3 protein (Slit-3) (Slit3) Slit3 Mus musculus (Mouse) TR32220_c1_g1_i4 P08953 TOLL_DROME 4.00E-11 GO:0033565; GO:0008063; GO:0019732; GO:0007155; GO:0019955; GO:0050830; GO:0005769; GO:0009897; GO:0007507; GO:0035172; GO:0030097; GO:0045087; GO:0016021; GO:0006963; GO:0006967; GO:0045610; GO:0007416; GO:0016201; GO:0004888; GO:0007352 Itself; Q7K105 ESCRT-0 complex; Toll signaling pathway; antifungal humoral response; cell adhesion; cytokine binding; defense response to Gram-positive bacterium; early endosome; external side of plasma membrane; heart development; hemocyte proliferation; hemopoiesis; innate immune response; integral to membrane; positive regulation of antibacterial peptide biosynthetic process; positive regulation of antifungal peptide biosynthetic process; regulation of hemocyte differentiation; synapse assembly; synaptic target inhibition; transmembrane signaling receptor activity; zygotic specification of dorsal/ventral axis IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) TR32220_c1_g1_i5 Q9WVB4 SLIT3_MOUSE 5.00E-15 GO:0035385; GO:0061364; GO:0048846; GO:0007411; GO:0005509; GO:0032870; GO:0005615; GO:0050919; GO:0030308; GO:0008285; GO:0070100; GO:0010629; GO:0009887; GO:0005102; GO:0051414 Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; axon guidance; calcium ion binding; cellular response to hormone stimulus; extracellular space; negative chemotaxis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of chemokine-mediated signaling pathway; negative regulation of gene expression; organ morphogenesis; receptor binding; response to cortisol stimulus IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 3 protein (Slit-3) (Slit3) Slit3 Mus musculus (Mouse) TR32222_c1_g1_i1 P62250 RS16_RAT 2.00E-89 GO:0003723; GO:0022627; GO:0006364; GO:0042274; GO:0003735; GO:0006412 RNA binding; cytosolic small ribosomal subunit; rRNA processing; ribosomal small subunit biogenesis; structural constituent of ribosome; translation IPR020568; IPR014721; IPR000754; IPR020574; 40S ribosomal protein S16 Rps16 Rattus norvegicus (Rat) TR32222_c2_g1_i2 P30347 LIGF_PSEPA 9.00E-06 GO:0046274 lignin catabolic process IPR010987; IPR004045; IPR004046; IPR012336; Protein LigF ligF Sphingomonas paucimobilis (Pseudomonas paucimobilis) TR32222_c2_g1_i3 P78417 GSTO1_HUMAN 3.00E-52 GO:0019852; GO:0071243; GO:0005829; GO:0045174; GO:1901687; GO:0004364; GO:0050610; GO:0060315; GO:0060316; GO:0014810; GO:0010881; GO:0042178 L-ascorbic acid metabolic process; cellular response to arsenic-containing substance; cytosol; glutathione dehydrogenase (ascorbate) activity; glutathione derivative biosynthetic process; glutathione transferase activity; methylarsonate reductase activity; negative regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; xenobiotic catabolic process IPR010987; IPR004045; IPR004046; IPR005442; IPR012336; Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R) GSTO1 GSTTLP28 Homo sapiens (Human) TR32222_c3_g4_i1 Q13360 ZN177_HUMAN 1.00E-24 GO:0003677; GO:0046872; GO:0000122; GO:0005634; GO:0006351 "DNA binding; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 177 ZNF177 Homo sapiens (Human) TR32222_c3_g5_i1 Q8NB50 ZFP62_HUMAN 3.00E-20 GO:0046872; GO:0003676; GO:0005634; GO:0006355; GO:0006351 "metal ion binding; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 62 homolog (Zfp-62) ZFP62 Homo sapiens (Human) TR32223_c5_g2_i2 O94966 UBP19_HUMAN 1.00E-07 GO:0030433; GO:0005829; GO:0005789; GO:0016021; GO:0046872; GO:0048642; GO:0090068; GO:0016579; GO:1900037; GO:0031647; GO:0034976; GO:0014732; GO:0004221; GO:0004843 ER-associated protein catabolic process; cytosol; endoplasmic reticulum membrane; integral to membrane; metal ion binding; negative regulation of skeletal muscle tissue development; positive regulation of cell cycle process; protein deubiquitination; regulation of cellular response to hypoxia; regulation of protein stability; response to endoplasmic reticulum stress; skeletal muscle atrophy; ubiquitin thiolesterase activity; ubiquitin-specific protease activity IPR007052; IPR008978; IPR018200; IPR001394; IPR002893; Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9) USP19 KIAA0891 ZMYND9 Homo sapiens (Human) TR32223_c5_g3_i2 O43827 ANGL7_HUMAN 9.00E-11 GO:0005576; GO:0006979 extracellular region; response to oxidative stress IPR014716; IPR014715; IPR002181; Angiopoietin-related protein 7 (Angiopoietin-like factor) (Angiopoietin-like protein 7) (Cornea-derived transcript 6 protein) ANGPTL7 CDT6 UNQ313/PRO356 Homo sapiens (Human) TR32223_c5_g3_i8 O43827 ANGL7_HUMAN 2.00E-10 GO:0005576; GO:0006979 extracellular region; response to oxidative stress IPR014716; IPR014715; IPR002181; Angiopoietin-related protein 7 (Angiopoietin-like factor) (Angiopoietin-like protein 7) (Cornea-derived transcript 6 protein) ANGPTL7 CDT6 UNQ313/PRO356 Homo sapiens (Human) TR32229_c0_g1_i1 Q58443 RPOH_METJA 1.00E-16 GO:0003677; GO:0003899; GO:0006351 "DNA binding; DNA-directed RNA polymerase activity; transcription, DNA-dependent" IPR000783; IPR020608; IPR020609; DNA-directed RNA polymerase subunit H (EC 2.7.7.6) rpoH MJ1039 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR32229_c0_g1_i2 Q09191 RPAB1_SCHPO 2.00E-54 GO:0003677; GO:0005736; GO:0005665; GO:0005666; GO:0003899; GO:0005829; GO:0006360; GO:0006366; GO:0006383 "DNA binding; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase activity; cytosol; transcription from RNA polymerase I promoter; transcription from RNA polymerase II promoter; transcription from RNA polymerase III promoter" IPR014381; IPR005571; IPR000783; IPR020608; IPR020609; "DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (RPC24B)" rpb5 SPAC23C4.15 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR32229_c0_g1_i3 B0BNE2 RPAB1_RAT 4.00E-127 GO:0003677; GO:0005736; GO:0005665; GO:0005666; GO:0003899; GO:0006360; GO:0006366; GO:0006383 "DNA binding; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase activity; transcription from RNA polymerase I promoter; transcription from RNA polymerase II promoter; transcription from RNA polymerase III promoter" IPR014381; IPR005571; IPR000783; IPR020608; IPR020609; "DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (DNA-directed RNA polymerase II subunit E) (RPB5 homolog)" Polr2e Rattus norvegicus (Rat) TR32230_c1_g1_i2 Q96JB6 LOXL4_HUMAN 5.00E-22 GO:0005507; GO:0005615; GO:0016020; GO:0004720; GO:0005044 O60341; Q96LA8; Q15645 copper ion binding; extracellular space; membrane; protein-lysine 6-oxidase activity; scavenger receptor activity IPR001695; IPR019828; IPR001190; IPR017448; Lysyl oxidase homolog 4 (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C) LOXL4 LOXC Homo sapiens (Human) TR32232_c4_g1_i1 Q54P70 Y4757_DICDI 9.00E-09 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR003323; OTU domain-containing protein DDB_G0284757 (EC 3.1.2.-) DDB_G0284757 Dictyostelium discoideum (Slime mold) TR32232_c4_g1_i6 Q54P70 Y4757_DICDI 5.00E-09 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR003323; OTU domain-containing protein DDB_G0284757 (EC 3.1.2.-) DDB_G0284757 Dictyostelium discoideum (Slime mold) TR32233_c0_g3_i1 Q8BZQ7 ANC2_MOUSE 3.00E-97 GO:0005680; GO:0030154; GO:0051301; GO:0007067; GO:0007399; GO:0090129; GO:0031915; GO:0070979; GO:0006511 anaphase-promoting complex; cell differentiation; cell division; mitosis; nervous system development; positive regulation of synapse maturation; positive regulation of synaptic plasticity; protein K11-linked ubiquitination; ubiquitin-dependent protein catabolic process IPR014786; IPR016158; IPR001373; IPR011991; Protein modification; protein ubiquitination. Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2) Anapc2 Mus musculus (Mouse) TR32234_c1_g1_i1 Q62036 AZI1_MOUSE 8.00E-07 GO:0030154; GO:0007275; GO:0007283 cell differentiation; multicellular organismal development; spermatogenesis IPR000048; 5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) Azi1 Az1 Azi Mus musculus (Mouse) TR32234_c5_g1_i1 Q9UPN4 AZI1_HUMAN 5.00E-109 GO:0000086; GO:0030154; GO:0005813; GO:0005829; GO:0043231; GO:0007275; GO:0007283 G2/M transition of mitotic cell cycle; cell differentiation; centrosome; cytosol; intracellular membrane-bounded organelle; multicellular organismal development; spermatogenesis 5-azacytidine-induced protein 1 (Centrosomal protein of 131 kDa) (Cep131) (Pre-acrosome localization protein 1) AZI1 CEP131 KIAA1118 Homo sapiens (Human) TR32237_c10_g1_i1 P42519 STAR_DROME 3.00E-17 GO:0005794; GO:0000139; GO:0048149; GO:0046845; GO:0046667; GO:0035225; GO:0005789; GO:0038004; GO:0007173; GO:0061331; GO:0007476; GO:0016021; GO:0007498; GO:0016318; GO:0048477; GO:0097038; GO:0007422; GO:0042461; GO:0005886; GO:0000042; GO:0048865; GO:0007421; GO:0007601 "Golgi apparatus; Golgi membrane; behavioral response to ethanol; branched duct epithelial cell fate determination, open tracheal system; compound eye retinal cell programmed cell death; determination of genital disc primordium; endoplasmic reticulum membrane; epidermal growth factor receptor ligand maturation; epidermal growth factor receptor signaling pathway; epithelial cell proliferation involved in Malpighian tubule morphogenesis; imaginal disc-derived wing morphogenesis; integral to membrane; mesoderm development; ommatidial rotation; oogenesis; perinuclear endoplasmic reticulum; peripheral nervous system development; photoreceptor cell development; plasma membrane; protein targeting to Golgi; stem cell fate commitment; stomatogastric nervous system development; visual perception" IPR006342; Protein Star S CG4385 Drosophila melanogaster (Fruit fly) TR32237_c5_g1_i1 Q5EA83 DCHS_BOVIN 1.00E-86 GO:0042423; GO:0001694; GO:0006548; GO:0004398; GO:0030170 catecholamine biosynthetic process; histamine biosynthetic process; histidine catabolic process; histidine decarboxylase activity; pyridoxal phosphate binding IPR010977; IPR002129; IPR015424; IPR015421; IPR015422; IPR021115; Amine and polyamine biosynthesis; histamine biosynthesis; histamine from L-histidine: step 1/1. Histidine decarboxylase (HDC) (EC 4.1.1.22) HDC Bos taurus (Bovine) TR32239_c0_g1_i1 A7Y2W8 SC6A9_XENLA 2.00E-27 GO:0005887; GO:0005328; GO:0005283 integral to plasma membrane; neurotransmitter:sodium symporter activity; sodium:amino acid symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9) slc6a9 glyt1 Xenopus laevis (African clawed frog) TR32239_c3_g1_i1 Q9HFY6 CALM_BLAEM 6.00E-12 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) CMD1 Blastocladiella emersonii (Aquatic fungus) TR32239_c7_g2_i1 Q948R0 CML5_ORYSJ 8.00E-48 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-like protein 5 (Calmodulin-2) (OsCAM-2) CML5 Os12g0603800 LOC_Os12g41110 OsJ_035343 Oryza sativa subsp. japonica (Rice) TR32239_c7_g2_i2 Q95NR9 CALM_METSE 4.00E-83 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Metridium senile (Brown sea anemone) (Frilled sea anemone) TR32239_c7_g2_i3 P18061 CALM_TRYCR 1.00E-76 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) CALA2 Trypanosoma cruzi TR32240_c2_g1_i2 Q8N1L4 CP4Z2_HUMAN 8.00E-31 GO:0020037; GO:0016021; GO:0005506; GO:0016705 "heme binding; integral to membrane; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; Putative inactive cytochrome P450 family member 4Z2 CYP4Z2P Homo sapiens (Human) TR32240_c3_g1_i1 Q64462 CP4B1_MOUSE 1.00E-60 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) Cyp4b1 Mus musculus (Mouse) TR32240_c3_g1_i10 Q1T7B9 CENPM_CHICK 3.00E-20 GO:0000775; GO:0005634 "chromosome, centromeric region; nucleus" IPR020987; Centromere protein M (CENP-M) CENPM Gallus gallus (Chicken) TR32240_c3_g1_i3 Q9NSP4 CENPM_HUMAN 1.00E-22 GO:0000777; GO:0005829; GO:0000278; GO:0005634 condensed chromosome kinetochore; cytosol; mitotic cell cycle; nucleus IPR020987; Centromere protein M (CENP-M) (Interphase centromere complex protein 39) (Proliferation-associated nuclear element protein 1) CENPM C22orf18 ICEN39 PANE1 Homo sapiens (Human) TR32240_c3_g1_i5 Q64462 CP4B1_MOUSE 4.00E-59 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) Cyp4b1 Mus musculus (Mouse) TR32240_c3_g1_i6 Q1T7B9 CENPM_CHICK 2.00E-30 GO:0000775; GO:0005634 "chromosome, centromeric region; nucleus" IPR020987; Centromere protein M (CENP-M) CENPM Gallus gallus (Chicken) TR32241_c3_g1_i1 Q96P66 GP101_HUMAN 2.00E-30 GO:0004935; GO:0071875; GO:0016021; GO:0005886 adrenergic receptor activity; adrenergic receptor signaling pathway; integral to membrane; plasma membrane IPR002233; IPR000276; IPR017452; Probable G-protein coupled receptor 101 GPR101 Homo sapiens (Human) TR32241_c3_g5_i1 B3DM66 GP161_XENTR 9.00E-41 GO:0004930; GO:0060170; GO:0016021; GO:0007275; GO:1901621; GO:0030819; GO:0072372; GO:0055037 G-protein coupled receptor activity; cilium membrane; integral to membrane; multicellular organismal development; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; positive regulation of cAMP biosynthetic process; primary cilium; recycling endosome IPR000276; IPR017452; G-protein coupled receptor 161 gpr161 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR32242_c0_g1_i2 Q2VPM9 TPPP3_XENLA 3.00E-14 GO:0005737; GO:0005874; GO:0001578; GO:0015631 cytoplasm; microtubule; microtubule bundle formation; tubulin binding IPR008907; Tubulin polymerization-promoting protein family member 3 tppp3 Xenopus laevis (African clawed frog) TR32244_c0_g1_i2 P52758 UK114_HUMAN 2.00E-58 GO:0005737; GO:0019239; GO:0004519; GO:0005739; GO:0090305; GO:0005634; GO:0006449 cytoplasm; deaminase activity; endonuclease activity; mitochondrion; nucleic acid phosphodiester bond hydrolysis; nucleus; regulation of translational termination IPR013813; IPR006056; IPR019897; IPR006175; Ribonuclease UK114 (EC 3.1.-.-) (14.5 kDa translational inhibitor protein) (p14.5) (Heat-responsive protein 12) (UK114 antigen homolog) HRSP12 PSP Homo sapiens (Human) TR32248_c0_g1_i1 Q9D0G0 RT30_MOUSE 3.00E-26 GO:0005739; GO:0005840; GO:0003735; GO:0006412 mitochondrion; ribosome; structural constituent of ribosome; translation IPR010793; "28S ribosomal protein S30, mitochondrial (MRP-S30) (S30mt)" Mrps30 Mus musculus (Mouse) TR32249_c0_g1_i1 Q8WXD5 GEMI6_HUMAN 1.00E-16 GO:0097504; GO:0005829; GO:0034660; GO:0016604; GO:0005681; GO:0000245; GO:0000387 P12520 Gemini of coiled bodies; cytosol; ncRNA metabolic process; nuclear body; spliceosomal complex; spliceosomal complex assembly; spliceosomal snRNP assembly IPR009422; Gem-associated protein 6 (Gemin-6) (SIP2) GEMIN6 Homo sapiens (Human) TR32249_c0_g1_i2 Q4V7L5 MED9_XENLA 2.00E-10 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR011425; Mediator of RNA polymerase II transcription subunit 9 (Mediator complex subunit 9) med9 Xenopus laevis (African clawed frog) TR32250_c0_g1_i2 Q9PU47 PDLI3_CHICK 1.00E-16 GO:0030018; GO:0005856; GO:0030027; GO:0008270 Z disc; cytoskeleton; lamellipodium; zinc ion binding IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein 3 (Alpha-actinin-associated LIM protein) PDLIM3 ALP Gallus gallus (Chicken) TR32251_c1_g1_i1 P18433 PTPRA_HUMAN 2.00E-19 GO:0007411; GO:0008286; GO:0005887; GO:0006468; GO:0005001 P14781; P39688; P62993; P00523; P12931 axon guidance; insulin receptor signaling pathway; integral to plasma membrane; protein phosphorylation; transmembrane receptor protein tyrosine phosphatase activity IPR000387; IPR016130; IPR000242; IPR016336; IPR027262; Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) TR32251_c1_g2_i1 P23471 PTPRZ_HUMAN 1.00E-07 GO:0007409; GO:0007417; GO:0005887; GO:0072534; GO:0008330; GO:0005578; GO:0005001 Q9UM73 axonogenesis; central nervous system development; integral to plasma membrane; perineuronal net; protein tyrosine/threonine phosphatase activity; proteinaceous extracellular matrix; transmembrane receptor protein tyrosine phosphatase activity IPR001148; IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2) PTPRZ1 HTPZP2 PTPRZ PTPRZ2 PTPZ Homo sapiens (Human) TR32251_c3_g1_i2 Q17QR8 HARB1_BOVIN 6.00E-18 GO:0005813; GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 centrosome; cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) HARBI1 Bos taurus (Bovine) TR32251_c4_g1_i1 Q6AZB8 HARB1_DANRE 3.00E-26 GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) TR32251_c8_g1_i1 Q5R5E8 HEPS_PONAB 1.00E-13 GO:0034769; GO:0015269; GO:0009986; GO:0005911; GO:0090103; GO:0050910; GO:0005789; GO:0005887; GO:0043066; GO:0050680; GO:0010719; GO:0043025; GO:0097195; GO:0043923; GO:0030307; GO:0010628; GO:2000347; GO:0010756; GO:2000611; GO:0006508; GO:0008360; GO:0097066; GO:0005044; GO:0004252; GO:0070008; GO:0008236 basement membrane disassembly; calcium-activated potassium channel activity; cell surface; cell-cell junction; cochlea morphogenesis; detection of mechanical stimulus involved in sensory perception of sound; endoplasmic reticulum membrane; integral to plasma membrane; negative regulation of apoptotic process; negative regulation of epithelial cell proliferation; negative regulation of epithelial to mesenchymal transition; neuronal cell body; pilomotor reflex; positive regulation by host of viral transcription; positive regulation of cell growth; positive regulation of gene expression; positive regulation of hepatocyte proliferation; positive regulation of plasminogen activation; positive regulation of thyroid hormone generation; proteolysis; regulation of cell shape; response to thyroid hormone stimulus; scavenger receptor activity; serine-type endopeptidase activity; serine-type exopeptidase activity; serine-type peptidase activity IPR015352; IPR001254; IPR018114; IPR001314; IPR017448; IPR009003; Serine protease hepsin (EC 3.4.21.106) (Transmembrane protease serine 1) [Cleaved into: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain] HPN TMPRSS1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR32254_c0_g2_i1 Q5R3Z8 FBXL2_PONAB 6.00E-18 GO:0016020 membrane IPR001810; IPR006553; F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) FBXL2 FBL2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR32255_c1_g1_i1 Q9ERH3 WDR7_RAT 2.00E-17 IPR016024; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 7 (TGF-beta resistance-associated protein TRAG) Wdr7 Trag Rattus norvegicus (Rat) TR32255_c2_g1_i1 Q5RFQ4 WDR72_PONAB 2.00E-22 IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 72 WDR72 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR32255_c4_g2_i1 Q9Y4E6 WDR7_HUMAN 2.00E-161 IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 7 (Rabconnectin-3 beta) (TGF-beta resistance-associated protein TRAG) WDR7 KIAA0541 TRAG Homo sapiens (Human) TR32256_c7_g1_i2 Q9CZJ2 HS12B_MOUSE 8.00E-67 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR32263_c1_g1_i1 O34309 PPS_BACSU 4.00E-24 GO:0005524; GO:0016301 ATP binding; kinase activity IPR013815; IPR013816; IPR008279; IPR002192; "Putative phosphoenolpyruvate synthase (Putative PEP synthase) (Pyruvate, water dikinase)" pps BSU18830 Bacillus subtilis (strain 168) TR32264_c1_g1_i1 Q68EK7 RAB4B_DANRE 2.00E-120 GO:0005525; GO:0005886; GO:0015031; GO:0007264 GTP binding; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-4B rab4b zgc:101015 Danio rerio (Zebrafish) (Brachydanio rerio) TR32266_c0_g1_i1 Q96MM6 HS12B_HUMAN 2.00E-105 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR32266_c0_g1_i2 B0KA81 DNAK_THEP3 2.00E-12 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK Teth39_1393 Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum) TR32266_c0_g1_i3 Q9CZJ2 HS12B_MOUSE 3.00E-75 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR32268_c1_g1_i2 Q76CA2 ACTP2_CYMEC 2.00E-14 GO:0019835; GO:0044179; GO:0016021; GO:0006811; GO:0044218 cytolysis; hemolysis in other organism; integral to membrane; ion transport; other organism cell membrane IPR015926; Echotoxin-2 (Echt 2) Cymatium echo (Giant triton) (Monoplex echo) TR32268_c1_g1_i3 P0DKQ8 ACTP_CONCN 1.00E-15 GO:0019835; GO:0044179; GO:0016021; GO:0006811; GO:0044218 cytolysis; hemolysis in other organism; integral to membrane; ion transport; other organism cell membrane IPR015926; Conoporin-Cn1 Conus consors (Singed cone) TR32269_c0_g1_i1 Q5M9B7 OSTCB_XENLA 1.00E-74 GO:0016021 integral to membrane IPR021149; Oligosaccharyltransferase complex subunit ostc-B ostc-b Xenopus laevis (African clawed frog) TR32270_c0_g2_i1 Q80XN0 BDH_MOUSE 6.00E-65 GO:0003858; GO:0060612; GO:0007420; GO:0001889; GO:0005743; GO:0005759; GO:0005543; GO:0046686; GO:0051412; GO:0042493; GO:0032355; GO:0045471; GO:0060416; GO:0032868; GO:0007584; GO:0042594; GO:0009636 3-hydroxybutyrate dehydrogenase activity; adipose tissue development; brain development; liver development; mitochondrial inner membrane; mitochondrial matrix; phospholipid binding; response to cadmium ion; response to corticosterone stimulus; response to drug; response to estradiol stimulus; response to ethanol; response to growth hormone stimulus; response to insulin stimulus; response to nutrient; response to starvation; response to toxic substance IPR002198; IPR002347; IPR016040; IPR020904; "D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase)" Bdh1 Bdh Mus musculus (Mouse) TR32271_c0_g1_i3 P07379 PCKGC_RAT 3.00E-143 GO:0019003; GO:0005525; GO:0031406; GO:0005829; GO:0006094; GO:0042593; GO:0046327; GO:0006475; GO:0000287; GO:0030145; GO:0006107; GO:0004613; GO:0014823; GO:0032868 GDP binding; GTP binding; carboxylic acid binding; cytosol; gluconeogenesis; glucose homeostasis; glycerol biosynthetic process from pyruvate; internal protein amino acid acetylation; magnesium ion binding; manganese ion binding; oxaloacetate metabolic process; phosphoenolpyruvate carboxykinase (GTP) activity; response to activity; response to insulin stimulus IPR018091; IPR013035; IPR008209; IPR008210; Carbohydrate biosynthesis; gluconeogenesis. "Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32) (Phosphoenolpyruvate carboxylase)" Pck1 Rattus norvegicus (Rat) TR32277_c6_g3_i1 P81282 CSPG2_BOVIN 5.00E-11 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Bos taurus (Bovine) TR32279_c8_g1_i1 Q8NEA6 GLIS3_HUMAN 7.00E-64 GO:0003677; GO:0046872; GO:0000122; GO:0005634; GO:0045944; GO:0003700; GO:0006366 DNA binding; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter IPR007087; IPR015880; IPR013087; Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515) GLIS3 ZNF515 Homo sapiens (Human) TR3228_c0_g1_i1 Q9NP59 S40A1_HUMAN 2.00E-12 GO:0009653; GO:0006915; GO:0006879; GO:0005737; GO:0003158; GO:0005887; GO:0005381; GO:0002260; GO:0060586; GO:0005771; GO:0060345; GO:0008021 P05067 anatomical structure morphogenesis; apoptotic process; cellular iron ion homeostasis; cytoplasm; endothelium development; integral to plasma membrane; iron ion transmembrane transporter activity; lymphocyte homeostasis; multicellular organismal iron ion homeostasis; multivesicular body; spleen trabecula formation; synaptic vesicle IPR009716; IPR016196; Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1) SLC40A1 FPN1 IREG1 SLC11A3 MSTP079 Homo sapiens (Human) TR32280_c0_g1_i1 Q5PXZ9 TIMP3_MACMU 7.00E-10 GO:0046872; GO:0008191; GO:0005578 metal ion binding; metalloendopeptidase inhibitor activity; proteinaceous extracellular matrix IPR001134; IPR001820; IPR008993; IPR027465; IPR015612; Metalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) (TIMP-3) TIMP3 Macaca mulatta (Rhesus macaque) TR32280_c0_g1_i3 Q5PXZ9 TIMP3_MACMU 3.00E-09 GO:0046872; GO:0008191; GO:0005578 metal ion binding; metalloendopeptidase inhibitor activity; proteinaceous extracellular matrix IPR001134; IPR001820; IPR008993; IPR027465; IPR015612; Metalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) (TIMP-3) TIMP3 Macaca mulatta (Rhesus macaque) TR32281_c0_g1_i1 Q9CQ24 FBX36_MOUSE 1.00E-27 IPR001810; F-box only protein 36 Fbxo36 Mus musculus (Mouse) TR32286_c1_g3_i1 E1C7U0 TM173_CHICK 4.00E-09 GO:0005794; GO:0002218; GO:0006915; GO:0071360; GO:0035458; GO:0061507; GO:0035438; GO:0051607; GO:0005789; GO:0045087; GO:0016021; GO:0032608; GO:0005741; GO:0048471; GO:0005777; GO:0005886; GO:0002230; GO:0032092; GO:0033160; GO:0042993; GO:0045944; GO:0042803 "Golgi apparatus; activation of innate immune response; apoptotic process; cellular response to exogenous dsRNA; cellular response to interferon-beta; cyclic-GMP-AMP binding; cyclic-di-GMP binding; defense response to virus; endoplasmic reticulum membrane; innate immune response; integral to membrane; interferon-beta production; mitochondrial outer membrane; perinuclear region of cytoplasm; peroxisome; plasma membrane; positive regulation of defense response to virus by host; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; protein homodimerization activity" Stimulator of interferon genes protein (STING) (Transmembrane protein 173) TMEM173 STING Gallus gallus (Chicken) TR32286_c1_g5_i1 A8E5V9 TM173_XENTR 8.00E-08 GO:0002218; GO:0006915; GO:0061507; GO:0035438; GO:0051607; GO:0005789; GO:0045087; GO:0016021; GO:0032608; GO:0005741; GO:0048471; GO:0005886; GO:0042803 activation of innate immune response; apoptotic process; cyclic-GMP-AMP binding; cyclic-di-GMP binding; defense response to virus; endoplasmic reticulum membrane; innate immune response; integral to membrane; interferon-beta production; mitochondrial outer membrane; perinuclear region of cytoplasm; plasma membrane; protein homodimerization activity Stimulator of interferon genes protein (STING) (Transmembrane protein 173) tmem173 sting Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR32286_c2_g1_i1 Q5SWK7 RN145_MOUSE 4.00E-35 GO:0016021; GO:0008270 integral to membrane; zinc ion binding IPR025754; IPR001841; IPR013083; RING finger protein 145 Rnf145 Mus musculus (Mouse) TR32290_c0_g1_i1 Q9BXX0 EMIL2_HUMAN 1.00E-07 GO:0007155; GO:0005581; GO:0030023; GO:0005576 cell adhesion; collagen; extracellular matrix constituent conferring elasticity; extracellular region IPR001073; IPR011489; IPR008983; EMILIN-2 (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10) EMILIN2 Homo sapiens (Human) TR32290_c0_g2_i1 Q4ZJM9 C1QL4_MOUSE 5.00E-09 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) TR32290_c0_g2_i2 Q9BXJ4 C1QT3_HUMAN 1.00E-06 GO:0035356; GO:0005581; GO:0005615; GO:0045444; GO:0042593; GO:0042347; GO:0010629; GO:0045721; GO:0050728; GO:1900165; GO:0071638; GO:0070374; GO:0070165; GO:0050715; GO:0051897; GO:0070206 cellular triglyceride homeostasis; collagen; extracellular space; fat cell differentiation; glucose homeostasis; negative regulation of NF-kappaB import into nucleus; negative regulation of gene expression; negative regulation of gluconeogenesis; negative regulation of inflammatory response; negative regulation of interleukin-6 secretion; negative regulation of monocyte chemotactic protein-1 production; positive regulation of ERK1 and ERK2 cascade; positive regulation of adiponectin secretion; positive regulation of cytokine secretion; positive regulation of protein kinase B signaling cascade; protein trimerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) TR32291_c0_g1_i1 Q8BHA0 IN80C_MOUSE 5.00E-44 GO:0006310; GO:0006281; GO:0071339; GO:0006355; GO:0006351 "DNA recombination; DNA repair; MLL1 complex; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR013272; INO80 complex subunit C Ino80c Mus musculus (Mouse) TR32292_c2_g1_i1 Q96524 CRY2_ARATH 3.00E-49 GO:0005524; GO:0003913; GO:0006281; GO:0009882; GO:0006338; GO:0010617; GO:0005634; GO:0009638; GO:0009911; GO:0018298; GO:0010075; GO:0009414; GO:0010118; GO:0005773 Itself; P43254; P14713 ATP binding; DNA photolyase activity; DNA repair; blue light photoreceptor activity; chromatin remodeling; circadian regulation of calcium ion oscillation; nucleus; phototropism; positive regulation of flower development; protein-chromophore linkage; regulation of meristem growth; response to water deprivation; stomatal movement; vacuole IPR002081; IPR014134; IPR018394; IPR006050; IPR005101; IPR014729; Cryptochrome-2 (Blue light photoreceptor) CRY2 PHH1 At1g04400 F19P19.14 Arabidopsis thaliana (Mouse-ear cress) TR32293_c2_g4_i1 Q10075 PCS_SCHPO 5.00E-39 GO:0046870; GO:0071243; GO:0071276; GO:0005829; GO:0016756; GO:0005634; GO:0046938 cadmium ion binding; cellular response to arsenic-containing substance; cellular response to cadmium ion; cytosol; glutathione gamma-glutamylcysteinyltransferase activity; nucleus; phytochelatin biosynthetic process IPR007719; Glutathione gamma-glutamylcysteinyltransferase (EC 2.3.2.15) (Phytochelatin synthase) SPAC3H1.10 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR32294_c0_g1_i4 Q9W429 S35B4_DROME 5.00E-54 GO:0036084; GO:0005457; GO:0005794; GO:0005462; GO:0005464; GO:0008643; GO:0005783; GO:0015012; GO:0016021; GO:0036066 GDP-fucose import into endoplasmic reticulum lumen; GDP-fucose transmembrane transporter activity; Golgi apparatus; UDP-N-acetylglucosamine transmembrane transporter activity; UDP-xylose transmembrane transporter activity; carbohydrate transport; endoplasmic reticulum; heparan sulfate proteoglycan biosynthetic process; integral to membrane; protein O-linked fucosylation IPR013657; UDP-xylose and UDP-N-acetylglucosamine transporter-like CG3774 Drosophila melanogaster (Fruit fly) TR32294_c1_g1_i1 Q7ZW46 S35B4_DANRE 2.00E-63 GO:0000139; GO:0008643; GO:0016021; GO:0055085 Golgi membrane; carbohydrate transport; integral to membrane; transmembrane transport IPR013657; UDP-xylose and UDP-N-acetylglucosamine transporter (Solute carrier family 35 member B4) slc35b4 zgc:55288 Danio rerio (Zebrafish) (Brachydanio rerio) TR32294_c1_g1_i2 Q95KB4 S35B4_MACFA 4.00E-63 GO:0000139; GO:0008643; GO:0016021; GO:0055085 Golgi membrane; carbohydrate transport; integral to membrane; transmembrane transport IPR013657; UDP-xylose and UDP-N-acetylglucosamine transporter (Solute carrier family 35 member B4) SLC35B4 QccE-22467 QmoA-11096 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR32295_c2_g1_i1 Q5HYK7 SH319_HUMAN 2.00E-50 GO:0005794; GO:0007010; GO:0005829; GO:0005634; GO:0005886; GO:0051044; GO:0006892; GO:0022604 Golgi apparatus; cytoskeleton organization; cytosol; nucleus; plasma membrane; positive regulation of membrane protein ectodomain proteolysis; post-Golgi vesicle-mediated transport; regulation of cell morphogenesis IPR000108; IPR011511; IPR001452; SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP) SH3D19 Homo sapiens (Human) TR32296_c2_g1_i1 Q6QNI4 C71AJ_AMMMJ 2.00E-25 GO:0005789; GO:0020037; GO:0016021; GO:0043231; GO:0005506; GO:0016709; GO:0002238 "endoplasmic reticulum membrane; heme binding; integral to membrane; intracellular membrane-bounded organelle; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; response to molecule of fungal origin" IPR001128; IPR017972; IPR002401; Psoralen synthase (EC 1.14.13.102) (Cytochrome P450 CYP71AJ1) CYP71AJ1 Ammi majus (Bishop's weed) TR32296_c2_g1_i2 Q07973 CP24A_HUMAN 3.00E-58 GO:0030342; GO:0008403; GO:0020037; GO:0005506; GO:0005743; GO:0004497; GO:0001649; GO:0016705; GO:0042369; GO:0070561; GO:0006805 "1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; heme binding; iron ion binding; mitochondrial inner membrane; monooxygenase activity; osteoblast differentiation; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; vitamin D catabolic process; vitamin D receptor signaling pathway; xenobiotic metabolic process" IPR001128; IPR017972; IPR002401; "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.13.126) (Cytochrome P450 24A1) (Cytochrome P450-CC24)" CYP24A1 CYP24 Homo sapiens (Human) TR32296_c2_g1_i5 Q4G0S4 C27C1_HUMAN 1.00E-34 GO:0020037; GO:0005506; GO:0016020; GO:0004497; GO:0016705 "heme binding; iron ion binding; membrane; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Cytochrome P450 27C1 (EC 1.14.-.-) CYP27C1 Homo sapiens (Human) TR32296_c2_g1_i7 Q07973 CP24A_HUMAN 3.00E-57 GO:0030342; GO:0008403; GO:0020037; GO:0005506; GO:0005743; GO:0004497; GO:0001649; GO:0016705; GO:0042369; GO:0070561; GO:0006805 "1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; heme binding; iron ion binding; mitochondrial inner membrane; monooxygenase activity; osteoblast differentiation; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; vitamin D catabolic process; vitamin D receptor signaling pathway; xenobiotic metabolic process" IPR001128; IPR017972; IPR002401; "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.13.126) (Cytochrome P450 24A1) (Cytochrome P450-CC24)" CYP24A1 CYP24 Homo sapiens (Human) TR32298_c0_g1_i1 Q8VEE0 RPE_MOUSE 1.00E-99 GO:0046872; GO:0006098; GO:0004750 metal ion binding; pentose-phosphate shunt; ribulose-phosphate 3-epimerase activity IPR013785; IPR026019; IPR000056; IPR011060; Ribulose-phosphate 3-epimerase (EC 5.1.3.1) (Ribulose-5-phosphate-epimerase) Rpe Mus musculus (Mouse) TR32298_c0_g1_i2 P46969 RPE_YEAST 9.00E-75 GO:0005829; GO:0046872; GO:0006098; GO:0004750 cytosol; metal ion binding; pentose-phosphate shunt; ribulose-phosphate 3-epimerase activity IPR013785; IPR026019; IPR000056; IPR011060; Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. Ribulose-phosphate 3-epimerase (EC 5.1.3.1) (Pentose-5-phosphate 3-epimerase) (PPE) (RPE) RPE1 EPI1 POS18 YJL121C J0731 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR32299_c1_g1_i1 Q9C040 TRIM2_HUMAN 4.00E-10 GO:0005737; GO:0043523; GO:0004842; GO:0008270 cytoplasm; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) TRIM2 KIAA0517 RNF86 Homo sapiens (Human) TR32299_c2_g1_i1 Q8VE42 ANR49_MOUSE 7.00E-43 GO:0045893 "positive regulation of transcription, DNA-dependent" IPR002110; IPR020683; Ankyrin repeat domain-containing protein 49 (Fetal globin-increasing factor) (Fetal globin-inducing factor) Ankrd49 Fgif Gbif Mus musculus (Mouse) TR32299_c2_g1_i2 O15084 ANR28_HUMAN 6.00E-16 GO:0005654 Q14185; O00743; Q9UPN7; O75170; Q5H9R7; Q9H2K2 nucleoplasm IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) ANKRD28 KIAA0379 Homo sapiens (Human) TR32299_c2_g1_i3 Q502K3 ANR52_DANRE 2.00E-14 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) TR32301_c1_g2_i3 Q28C98 MESH1_XENTR 4.00E-59 GO:0008893; GO:0008152; GO:0046872; GO:0008081 "guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity; metabolic process; metal ion binding; phosphoric diester hydrolase activity" IPR003607; IPR006674; "Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (MESH1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase)" hddc3 Mesh1 TGas061b07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR32302_c2_g1_i2 Q68FE8 Z280D_MOUSE 2.00E-23 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025243; IPR007087; IPR015880; Zinc finger protein 280D (Suppressor of hairy wing homolog 4) Znf280d Suhw4 Zfp280d Mus musculus (Mouse) TR32302_c2_g2_i1 Q8BZH4 POGZ_MOUSE 4.00E-19 GO:0003677; GO:0051301; GO:0005737; GO:0051382; GO:0046872; GO:0007064; GO:0000790 DNA binding; cell division; cytoplasm; kinetochore assembly; metal ion binding; mitotic sister chromatid cohesion; nuclear chromatin IPR004875; IPR009057; IPR006600; IPR007087; IPR015880; Pogo transposable element with ZNF domain Pogz Kiaa0461 Mus musculus (Mouse) TR32304_c3_g2_i1 P22105 TENX_HUMAN 9.00E-08 GO:0030036; GO:0007155; GO:0016337; GO:0007160; GO:0030199; GO:0032963; GO:0048251; GO:0043206; GO:0005615; GO:0006631; GO:0008201; GO:0005178; GO:0005622; GO:0005578; GO:0043506; GO:0006641 actin cytoskeleton organization; cell adhesion; cell-cell adhesion; cell-matrix adhesion; collagen fibril organization; collagen metabolic process; elastic fiber assembly; extracellular fibril organization; extracellular space; fatty acid metabolic process; heparin binding; integrin binding; intracellular; proteinaceous extracellular matrix; regulation of JUN kinase activity; triglyceride metabolic process IPR000742; IPR013032; IPR014716; IPR014715; IPR002181; IPR020837; IPR003961; IPR013783; Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) TR32305_c2_g2_i2 O74180 AOX_ASPNG 2.00E-74 GO:0009916; GO:0016021; GO:0046872; GO:0005743; GO:0070469 alternative oxidase activity; integral to membrane; metal ion binding; mitochondrial inner membrane; respiratory chain IPR002680; "Alternative oxidase, mitochondrial (EC 1.-.-.-)" aox1 Aspergillus niger TR32305_c2_g2_i3 Q8NKE2 AOX_CRYNV 3.00E-75 GO:0009916; GO:0016021; GO:0046872; GO:0005743; GO:0070469 alternative oxidase activity; integral to membrane; metal ion binding; mitochondrial inner membrane; respiratory chain IPR002680; "Alternative oxidase, mitochondrial (EC 1.-.-.-)" AOX1 CNAG_00162 Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) TR32305_c2_g2_i4 O74180 AOX_ASPNG 4.00E-77 GO:0009916; GO:0016021; GO:0046872; GO:0005743; GO:0070469 alternative oxidase activity; integral to membrane; metal ion binding; mitochondrial inner membrane; respiratory chain IPR002680; "Alternative oxidase, mitochondrial (EC 1.-.-.-)" aox1 Aspergillus niger TR32306_c1_g1_i1 O70247 SC5A6_RAT 3.00E-134 GO:0015878; GO:0031526; GO:0016021; GO:0015887; GO:0008523; GO:0012506 biotin transport; brush border membrane; integral to membrane; pantothenate transmembrane transport; sodium-dependent multivitamin transmembrane transporter activity; vesicle membrane IPR001734; IPR018212; IPR019900; Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (Solute carrier family 5 member 6) Slc5a6 Smvt Rattus norvegicus (Rat) TR32306_c1_g1_i4 Q5SWY8 SC5AA_MOUSE 4.00E-15 GO:0016021; GO:0005886; GO:0006814; GO:0055085; GO:0005215 integral to membrane; plasma membrane; sodium ion transport; transmembrane transport; transporter activity IPR001734; IPR018212; IPR019900; Sodium/glucose cotransporter 5 (Na(+)/glucose cotransporter 5) (Solute carrier family 5 member 10) Slc5a10 Sglt5 Mus musculus (Mouse) TR32306_c1_g1_i5 Q7T384 SC5AC_DANRE 3.00E-115 GO:0016021; GO:0015355; GO:0006814; GO:0015293 integral to membrane; secondary active monocarboxylate transmembrane transporter activity; sodium ion transport; symporter activity IPR001734; IPR019900; Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (zSMCTn) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12) (zSLC5A12) slc5a12 smctn Danio rerio (Zebrafish) (Brachydanio rerio) TR32306_c2_g1_i1 Q86Y13 DZIP3_HUMAN 4.00E-24 GO:0003723; GO:0005737; GO:0019902; GO:0031593; GO:0000209; GO:0004842; GO:0008270 Q9H0E2 RNA binding; cytoplasm; phosphatase binding; polyubiquitin binding; protein polyubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) TR32306_c3_g1_i1 Q9Y543 HES2_HUMAN 1.00E-08 GO:0003690; GO:0045892; GO:0005634; GO:0008134; GO:0006351 "double-stranded DNA binding; negative regulation of transcription, DNA-dependent; nucleus; transcription factor binding; transcription, DNA-dependent" IPR011598; IPR003650; IPR018352; Transcription factor HES-2 (Class B basic helix-loop-helix protein 40) (bHLHb40) (Hairy and enhancer of split 2) HES2 BHLHB40 Homo sapiens (Human) TR32308_c0_g1_i1 O02827 MYLK_SHEEP 1.00E-100 GO:0005524; GO:0032154; GO:0005737; GO:0005856; GO:0030027; GO:0046872; GO:0004687 ATP binding; cleavage furrow; cytoplasm; cytoskeleton; lamellipodium; metal ion binding; myosin light chain kinase activity IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR020675; IPR000719; IPR002290; IPR008271; "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] (Fragment)" MYLK Ovis aries (Sheep) TR32308_c0_g2_i1 P16419 MYPC2_CHICK 4.00E-12 GO:0007155; GO:0032982 cell adhesion; myosin filament IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; "Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform)" MYBPC2 Gallus gallus (Chicken) TR32309_c0_g1_i1 Q0VG49 CO061_MOUSE 4.00E-50 GO:0005576 extracellular region Uncharacterized protein C15orf61 homolog Mus musculus (Mouse) TR32310_c0_g1_i1 Q4UKQ3 RLUC_RICFE 3.00E-06 GO:0003723; GO:0009982; GO:0001522; GO:0006364 RNA binding; pseudouridine synthase activity; pseudouridine synthesis; rRNA processing IPR020103; IPR006224; IPR006145; IPR002942; Ribosomal large subunit pseudouridine synthase C (EC 5.4.99.24) (23S rRNA pseudouridine(955/2504/2580) synthase) (rRNA pseudouridylate synthase C) (rRNA-uridine isomerase C) rluC RF_1023 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR32310_c0_g1_i2 Q9ZKP5 Y956_HELPJ 1.00E-11 GO:0003723; GO:0009982; GO:0001522 RNA binding; pseudouridine synthase activity; pseudouridine synthesis IPR020103; IPR006224; IPR006145; IPR002942; Uncharacterized RNA pseudouridine synthase jhp_0890 (EC 5.4.99.-) (RNA pseudouridylate synthase) (RNA-uridine isomerase) jhp_0890 Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) TR32310_c0_g1_i3 Q08C69 RUSD1_DANRE 3.00E-68 GO:0003723; GO:0009982; GO:0001522 RNA binding; pseudouridine synthase activity; pseudouridine synthesis IPR020103; IPR006145; RNA pseudouridylate synthase domain-containing protein 1 rpusd1 zgc:153465 Danio rerio (Zebrafish) (Brachydanio rerio) TR32311_c0_g1_i1 Q5VYX0 RNLS_HUMAN 4.00E-101 GO:0005576; GO:0016491 extracellular region; oxidoreductase activity IPR002937; Renalase (EC 1.4.-.-) (Monoamine oxidase-C) (MAO-C) RNLS C10orf59 Homo sapiens (Human) TR32314_c4_g1_i1 Q9ER71 RHOJ_MOUSE 4.00E-22 GO:0005525; GO:0003924; GO:0007266; GO:0030036; GO:0005622; GO:0005886; GO:0008360; GO:0061299 GTP binding; GTPase activity; Rho protein signal transduction; actin cytoskeleton organization; intracellular; plasma membrane; regulation of cell shape; retina vasculature morphogenesis in camera-type eye IPR027417; IPR005225; IPR001806; IPR003578; Rho-related GTP-binding protein RhoJ (Tc10-like GTP-binding protein) Rhoj Arhj Rhoi Rhot Tc10l Tcl Mus musculus (Mouse) TR32315_c0_g1_i1 Q55EI6 ATX10_DICDI 4.00E-19 GO:0005737 cytoplasm IPR011989; IPR016024; IPR019156; Ataxin-10 homolog atxn10 DDB_G0268880 Dictyostelium discoideum (Slime mold) TR32315_c0_g1_i2 P28658 ATX10_MOUSE 2.00E-44 GO:0005829; GO:0030425; GO:0031175; GO:0043025; GO:0048471 Q8BP00 cytosol; dendrite; neuron projection development; neuronal cell body; perinuclear region of cytoplasm IPR011989; IPR016024; IPR019156; Ataxin-10 (Brain protein E46) (Spinocerebellar ataxia type 10 protein homolog) Atxn10 Sca10 Mus musculus (Mouse) TR32316_c1_g1_i3 Q15366 PCBP2_HUMAN 4.00E-27 GO:0003677; GO:0003723; GO:0005829; GO:0051607; GO:0045087; GO:0000398; GO:0050687; GO:0032480; GO:0005654; GO:0043161; GO:0030529 Q15365; P84103 "DNA binding; RNA binding; cytosol; defense response to virus; innate immune response; mRNA splicing, via spliceosome; negative regulation of defense response to virus; negative regulation of type I interferon production; nucleoplasm; proteasomal ubiquitin-dependent protein catabolic process; ribonucleoprotein complex" IPR004087; IPR004088; Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) PCBP2 Homo sapiens (Human) TR32316_c1_g1_i4 Q5ZIQ3 HNRPK_CHICK 1.00E-65 GO:0003677; GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0005654; GO:0006355; GO:0005681; GO:0006351 "DNA binding; RNA binding; RNA splicing; cytoplasm; mRNA processing; nucleoplasm; regulation of transcription, DNA-dependent; spliceosomal complex; transcription, DNA-dependent" IPR004087; IPR004088; IPR012987; Heterogeneous nuclear ribonucleoprotein K (hnRNP K) HNRNPK HNRPK RCJMB04_24e23 Gallus gallus (Chicken) TR32316_c1_g1_i5 Q15366 PCBP2_HUMAN 1.00E-15 GO:0003677; GO:0003723; GO:0005829; GO:0051607; GO:0045087; GO:0000398; GO:0050687; GO:0032480; GO:0005654; GO:0043161; GO:0030529 Q15365; P84103 "DNA binding; RNA binding; cytosol; defense response to virus; innate immune response; mRNA splicing, via spliceosome; negative regulation of defense response to virus; negative regulation of type I interferon production; nucleoplasm; proteasomal ubiquitin-dependent protein catabolic process; ribonucleoprotein complex" IPR004087; IPR004088; Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) PCBP2 Homo sapiens (Human) TR32316_c1_g1_i6 Q3T0D0 HNRPK_BOVIN 2.00E-33 GO:0003677; GO:0003723; GO:0008380; GO:0030054; GO:0042995; GO:0005737; GO:0006397; GO:0005654; GO:0002102; GO:0006355; GO:0005681; GO:0006351 "DNA binding; RNA binding; RNA splicing; cell junction; cell projection; cytoplasm; mRNA processing; nucleoplasm; podosome; regulation of transcription, DNA-dependent; spliceosomal complex; transcription, DNA-dependent" IPR004087; IPR004088; IPR012987; Heterogeneous nuclear ribonucleoprotein K (hnRNP K) HNRNPK HNRPK Bos taurus (Bovine) TR32316_c1_g1_i7 Q5ZIQ3 HNRPK_CHICK 2.00E-37 GO:0003677; GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0005654; GO:0006355; GO:0005681; GO:0006351 "DNA binding; RNA binding; RNA splicing; cytoplasm; mRNA processing; nucleoplasm; regulation of transcription, DNA-dependent; spliceosomal complex; transcription, DNA-dependent" IPR004087; IPR004088; IPR012987; Heterogeneous nuclear ribonucleoprotein K (hnRNP K) HNRNPK HNRPK RCJMB04_24e23 Gallus gallus (Chicken) TR32322_c3_g1_i1 Q5ZL12 PPR21_CHICK 7.00E-43 GO:0019902 phosphatase binding IPR019348; IPR019343; Protein phosphatase 1 regulatory subunit 21 (Coiled-coil domain-containing protein 128) (KLRAQ motif-containing protein 1) PPP1R21 CCDC128 KLRAQ1 RCJMB04_8e10 Gallus gallus (Chicken) TR32323_c0_g1_i1 P53397 OGG1_YEAST 3.00E-50 GO:0006285; GO:0003684; GO:0005739; GO:0006289; GO:0005634; GO:0008534 "base-excision repair, AP site formation; damaged DNA binding; mitochondrion; nucleotide-excision repair; nucleus; oxidized purine nucleobase lesion DNA N-glycosylase activity" IPR011257; IPR003265; IPR023170; IPR004577; IPR012904; N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)] OGG1 YML060W YM9958.02 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR32323_c0_g1_i2 O08760 OGG1_MOUSE 3.00E-93 GO:0034039; GO:0006284; GO:0003684; GO:0008017; GO:0005739; GO:0016363; GO:0016607; GO:0006289; GO:0033158; GO:0006355; GO:0006979; GO:0009314 "8-oxo-7,8-dihydroguanine DNA N-glycosylase activity; base-excision repair; damaged DNA binding; microtubule binding; mitochondrion; nuclear matrix; nuclear speck; nucleotide-excision repair; regulation of protein import into nucleus, translocation; regulation of transcription, DNA-dependent; response to oxidative stress; response to radiation" IPR011257; IPR003265; IPR023170; IPR004577; IPR012904; N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)] Ogg1 Mus musculus (Mouse) TR32325_c2_g1_i1 Q9W0T1 NU301_DROME 2.00E-92 GO:0003677; GO:0016589; GO:0048813; GO:0035076; GO:0030097; GO:0046331; GO:0007095; GO:0042766; GO:0045747; GO:0035073; GO:0006357; GO:0006351; GO:0008270 "DNA binding; NURF complex; dendrite morphogenesis; ecdysone receptor-mediated signaling pathway; hemopoiesis; lateral inhibition; mitotic G2 DNA damage checkpoint; nucleosome mobilization; positive regulation of Notch signaling pathway; pupariation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; zinc ion binding" IPR017956; IPR001487; IPR018359; IPR004022; IPR018500; IPR018501; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Nucleosome-remodeling factor subunit NURF301 (Enhancer of bithorax) (Nucleosome-remodeling factor 215 kDa subunit) (NURF-215) E(bx) CG32346 CG7022 Nurf301 Drosophila melanogaster (Fruit fly) TR32327_c0_g1_i1 P37967 PNBA_BACSU 3.00E-55 GO:0004091; GO:0004104 carboxylesterase activity; cholinesterase activity IPR002018; IPR019826; IPR019819; IPR000997; Para-nitrobenzyl esterase (EC 3.1.1.-) (Intracellular esterase B) (PNB carboxy-esterase) (PNBCE) pnbA estB BSU34390 Bacillus subtilis (strain 168) TR32328_c1_g1_i1 Q27433 MEC2_CAEEL 2.00E-86 GO:0016021; GO:0007638; GO:0032589 integral to membrane; mechanosensory behavior; neuron projection membrane IPR001107; IPR018080; IPR001972; Mechanosensory protein 2 mec-2 F14D12.4 Caenorhabditis elegans TR32329_c0_g1_i1 Q9CQ10 CHMP3_MOUSE 2.00E-40 GO:0000910; GO:0005829; GO:0005769; GO:0008333; GO:0031902; GO:0030496; GO:0005546; GO:0015031; GO:0051036 "cytokinesis; cytosol; early endosome; endosome to lysosome transport; late endosome membrane; midbody; phosphatidylinositol-4,5-bisphosphate binding; protein transport; regulation of endosome size" IPR005024; Charged multivesicular body protein 3 (Chromatin-modifying protein 3) (Vacuolar protein sorting-associated protein 24) Chmp3 Vps24 Mus musculus (Mouse) TR32331_c1_g1_i1 P80090 MPI3_LYMST 7.00E-15 GO:0005576; GO:0030133 extracellular region; transport vesicle IPR016179; IPR016724; IPR022353; IPR022352; Molluscan insulin-related peptide 3 (MIP III) [Cleaved into: Molluscan insulin-related peptide 3 B chain; Molluscan insulin-related peptide 3 A chain] Lymnaea stagnalis (Great pond snail) TR32332_c0_g2_i1 P12297 SUWA_DROME 7.00E-16 GO:0003723; GO:0008380; GO:0006397; GO:0016607; GO:0006355; GO:0006351 "RNA binding; RNA splicing; mRNA processing; nuclear speck; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000061; IPR019147; Protein suppressor of white apricot su(w[a]) su(wa) CG3019 Drosophila melanogaster (Fruit fly) TR32332_c0_g2_i2 Q8K4Z5 SF3A1_MOUSE 5.00E-08 GO:0003723; GO:0005684; GO:0071013; GO:0000398 "RNA binding; U2-type spliceosomal complex; catalytic step 2 spliceosome; mRNA splicing, via spliceosome" IPR022030; IPR000061; IPR000626; Splicing factor 3A subunit 1 (SF3a120) Sf3a1 Mus musculus (Mouse) TR32332_c0_g2_i3 P12297 SUWA_DROME 1.00E-15 GO:0003723; GO:0008380; GO:0006397; GO:0016607; GO:0006355; GO:0006351 "RNA binding; RNA splicing; mRNA processing; nuclear speck; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000061; IPR019147; Protein suppressor of white apricot su(w[a]) su(wa) CG3019 Drosophila melanogaster (Fruit fly) TR32334_c2_g1_i2 P82929 RT34_BOVIN 3.00E-16 GO:0005739; GO:0005840 mitochondrion; ribosome "28S ribosomal protein S34, mitochondrial (MRP-S34) (S34mt)" MRPS34 Bos taurus (Bovine) TR32338_c1_g2_i1 B5X5N3 SKA2_SALSA 9.00E-10 GO:0051301; GO:0007059; GO:0000940; GO:0005737; GO:0008017; GO:0007067; GO:0031110; GO:0005876 cell division; chromosome segregation; condensed chromosome outer kinetochore; cytoplasm; microtubule binding; mitosis; regulation of microtubule polymerization or depolymerization; spindle microtubule Spindle and kinetochore-associated protein 2 (Protein FAM33A) ska2 fam33a Salmo salar (Atlantic salmon) TR32338_c1_g2_i2 Q0P426 SKA2_DANRE 6.00E-14 GO:0051301; GO:0007059; GO:0000940; GO:0005737; GO:0008017; GO:0007067; GO:0031110; GO:0005876 cell division; chromosome segregation; condensed chromosome outer kinetochore; cytoplasm; microtubule binding; mitosis; regulation of microtubule polymerization or depolymerization; spindle microtubule Spindle and kinetochore-associated protein 2 (Protein FAM33A) ska2 fam33a Danio rerio (Zebrafish) (Brachydanio rerio) TR32339_c1_g1_i1 Q99715 COCA1_HUMAN 7.00E-22 GO:0007155; GO:0030574; GO:0030199; GO:0005595; GO:0005788; GO:0022617; GO:0030020; GO:0005615; GO:0070062; GO:0001501 cell adhesion; collagen catabolic process; collagen fibril organization; collagen type XII; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular matrix structural constituent conferring tensile strength; extracellular space; extracellular vesicular exosome; skeletal system development IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) TR32339_c2_g1_i4 Q8CIZ8 VWF_MOUSE 3.00E-07 GO:0033093; GO:0031589; GO:0051087; GO:0005518; GO:0005783; GO:0009897; GO:0031012; GO:0005576; GO:0001948; GO:0019865; GO:0005178; GO:0001889; GO:0001890; GO:0030168; GO:0002020; GO:0047485; GO:0042803; GO:0051260; GO:0005578 Weibel-Palade body; cell-substrate adhesion; chaperone binding; collagen binding; endoplasmic reticulum; external side of plasma membrane; extracellular matrix; extracellular region; glycoprotein binding; immunoglobulin binding; integrin binding; liver development; placenta development; platelet activation; protease binding; protein N-terminus binding; protein homodimerization activity; protein homooligomerization; proteinaceous extracellular matrix IPR006207; IPR002919; IPR014853; IPR012011; IPR002035; IPR001007; IPR001846; von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)] Vwf Mus musculus (Mouse) TR32341_c0_g2_i1 Q7KVW5 KCNN_DROME 4.00E-69 GO:0016021; GO:0009881; GO:0016057; GO:0016286 integral to membrane; photoreceptor activity; regulation of membrane potential in photoreceptor cell; small conductance calcium-activated potassium channel activity IPR013099; IPR004178; IPR015449; Small conductance calcium-activated potassium channel protein (Protein SK) (dSK) SK CG10706 Drosophila melanogaster (Fruit fly) TR32341_c0_g2_i2 Q9H2S1 KCNN2_HUMAN 2.00E-74 GO:0016021; GO:0005886; GO:1901379; GO:0016286; GO:0007268 integral to membrane; plasma membrane; regulation of potassium ion transmembrane transport; small conductance calcium-activated potassium channel activity; synaptic transmission IPR013099; IPR004178; IPR015449; Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2) KCNN2 Homo sapiens (Human) TR32341_c0_g2_i4 P58390 KCNN2_MOUSE 2.00E-74 GO:0030315; GO:0030018; GO:0043197; GO:0016021; GO:0005886; GO:1901379; GO:0016286; GO:0005790 T-tubule; Z disc; dendritic spine; integral to membrane; plasma membrane; regulation of potassium ion transmembrane transport; small conductance calcium-activated potassium channel activity; smooth endoplasmic reticulum IPR013099; IPR004178; IPR015449; Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2) Kcnn2 Sk2 Mus musculus (Mouse) TR32341_c0_g2_i6 Q2K5E1 CNGK1_RHIEC 2.00E-06 GO:0030552; GO:0016021; GO:0005886; GO:0005267 cAMP binding; integral to membrane; plasma membrane; potassium channel activity IPR013099; IPR018490; IPR018488; IPR000595; IPR003091; IPR027378; IPR014710; Cyclic nucleotide-gated potassium channel RHE_CH03180 RHE_CH03180 Rhizobium etli (strain CFN 42 / ATCC 51251) TR32344_c2_g1_i2 Q91987 NTRK2_CHICK 1.00E-149 GO:0005524; GO:0048403; GO:0060175; GO:0021954; GO:0021987; GO:0010008; GO:0005887; GO:0007612; GO:0043524; GO:0001764; GO:0043410; GO:0050772; GO:0008284; GO:0010628; GO:0010976; GO:0014068; GO:0046777; GO:0042803; GO:0032314 ATP binding; brain-derived neurotrophic factor binding; brain-derived neurotrophic factor-activated receptor activity; central nervous system neuron development; cerebral cortex development; endosome membrane; integral to plasma membrane; learning; negative regulation of neuron apoptotic process; neuron migration; positive regulation of MAPK cascade; positive regulation of axonogenesis; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of neuron projection development; positive regulation of phosphatidylinositol 3-kinase cascade; protein autophosphorylation; protein homodimerization activity; regulation of Rac GTPase activity IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR001611; IPR000372; IPR000719; IPR017441; IPR001245; IPR020455; IPR008266; IPR020635; IPR020777; IPR002011; BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) NTRK2 TRKB Gallus gallus (Chicken) TR32344_c2_g2_i1 Q6UXK5 LRRN1_HUMAN 5.00E-12 GO:0016021 integral to membrane IPR000483; IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeat neuronal protein 1 (Neuronal leucine-rich repeat protein 1) (NLRR-1) LRRN1 KIAA1497 Nbla10449 UNQ693/PRO1338 Homo sapiens (Human) TR32346_c0_g1_i1 P98157 LRP1_CHICK 5.00E-19 GO:0005509; GO:0005905; GO:0006897; GO:0016021 calcium ion binding; coated pit; endocytosis; integral to membrane IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) LRP1 Gallus gallus (Chicken) TR32348_c1_g1_i2 Q5E9N4 AADAT_BOVIN 8.00E-157 GO:0047536; GO:0006103; GO:0033512; GO:0009058; GO:0006536; GO:0016212; GO:0005739; GO:0030170 2-aminoadipate transaminase activity; 2-oxoglutarate metabolic process; L-lysine catabolic process to acetyl-CoA via saccharopine; biosynthetic process; glutamate metabolic process; kynurenine-oxoglutarate transaminase activity; mitochondrion; pyridoxal phosphate binding IPR004839; IPR015424; IPR015421; IPR015422; Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 4/6. "Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (KAT/AadAT) (2-aminoadipate aminotransferase) (2-aminoadipate transaminase) (EC 2.6.1.39) (Alpha-aminoadipate aminotransferase) (AadAT) (Kynurenine aminotransferase II) (Kynurenine--oxoglutarate aminotransferase II) (Kynurenine--oxoglutarate transaminase 2) (EC 2.6.1.7) (Kynurenine--oxoglutarate transaminase II)" AADAT Bos taurus (Bovine) TR32349_c0_g3_i3 P70665 SIAE_MOUSE 9.00E-108 GO:0004091; GO:0005764; GO:0001681 carboxylesterase activity; lysosome; sialate O-acetylesterase activity IPR005181; Sialate O-acetylesterase (EC 3.1.1.53) (Sialic acid-specific 9-O-acetylesterase) (Yolk sac protein 2) [Cleaved into: Sialate O-acetylesterase small subunit; Sialate O-acetylesterase large subunit] Siae Ysg2 Mus musculus (Mouse) TR32351_c1_g1_i1 Q01406 SRC8_CHICK 4.00E-77 GO:0005856; GO:0043197; GO:0005783; GO:0030027; GO:0005886; GO:0001726 P39054; Q8AYS8 cytoskeleton; dendritic spine; endoplasmic reticulum; lamellipodium; plasma membrane; ruffle IPR015503; IPR003134; IPR000108; IPR001452; Src substrate protein p85 (Cortactin) (p80) CTTN1 EMS1 P85.25 Gallus gallus (Chicken) TR32351_c1_g1_i2 Q9UJU6 DBNL_HUMAN 6.00E-17 GO:0000139; GO:0016601; GO:0051015; GO:0007257; GO:0005938; GO:0030054; GO:0006921; GO:0030665; GO:0005829; GO:0030425; GO:0006897; GO:0008047; GO:0030027; GO:0048812; GO:0005886; GO:0002102; GO:0071800; GO:0014069; GO:0001726; GO:0007416 Q9H788; P78314 Golgi membrane; Rac protein signal transduction; actin filament binding; activation of JUN kinase activity; cell cortex; cell junction; cellular component disassembly involved in execution phase of apoptosis; clathrin-coated vesicle membrane; cytosol; dendrite; endocytosis; enzyme activator activity; lamellipodium; neuron projection morphogenesis; plasma membrane; podosome; podosome assembly; postsynaptic density; ruffle; synapse assembly IPR002108; IPR001452; Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) DBNL CMAP SH3P7 PP5423 Homo sapiens (Human) TR32353_c1_g1_i2 P17027 ZNF23_HUMAN 1.00E-28 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 23 (Zinc finger protein 359) (Zinc finger protein 612) (Zinc finger protein KOX16) ZNF23 KOX16 ZNF359 ZNF612 Homo sapiens (Human) TR32354_c0_g1_i6 Q9D172 ES1_MOUSE 1.00E-107 GO:0005739 mitochondrion IPR002818; "ES1 protein homolog, mitochondrial" D10Jhu81e Mus musculus (Mouse) TR32355_c0_g1_i1 P83425 HIP_MYTED 2.00E-32 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR32355_c0_g1_i2 P83425 HIP_MYTED 7.00E-34 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR32355_c0_g1_i3 Q6UW01 CBLN3_HUMAN 1.00E-07 GO:0005794; GO:0030054; GO:0005783; GO:0005615; GO:0045202 Golgi apparatus; cell junction; endoplasmic reticulum; extracellular space; synapse IPR001073; IPR008983; Cerebellin-3 CBLN3 UNQ755/PRO1486 Homo sapiens (Human) TR32357_c0_g4_i1 A7MB89 FEM1C_BOVIN 9.00E-09 GO:0005737; GO:0016567 cytoplasm; protein ubiquitination IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog C (FEM1c) (FEM1-gamma) FEM1C Bos taurus (Bovine) TR32357_c0_g4_i2 A7MB89 FEM1C_BOVIN 9.00E-09 GO:0005737; GO:0016567 cytoplasm; protein ubiquitination IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog C (FEM1c) (FEM1-gamma) FEM1C Bos taurus (Bovine) TR32357_c0_g4_i3 Q9VFD5 FEM1A_DROME 4.00E-09 GO:0051438; GO:0004842 regulation of ubiquitin-protein ligase activity; ubiquitin-protein ligase activity IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog CG6966 CG6966 Drosophila melanogaster (Fruit fly) TR32358_c0_g3_i1 Q9BXY0 MAK16_HUMAN 3.00E-103 GO:0005730 nucleolus IPR006958; Protein MAK16 homolog (NNP78) (Protein RBM13) MAK16 RBM13 Homo sapiens (Human) TR32358_c0_g3_i2 Q66L33 MK16A_XENLA 1.00E-103 GO:0005730 nucleolus IPR006958; Protein MAK16 homolog A (MAK16-like protein A) mak16-a mak16l-a Xenopus laevis (African clawed frog) TR32359_c1_g3_i3 P0AC83 LGUL_SHIFL 5.00E-12 GO:0004462; GO:0046872 lactoylglutathione lyase activity; metal ion binding IPR004360; IPR004361; IPR018146; Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2. Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) gloA SF1678 S1810 Shigella flexneri TR32359_c1_g3_i4 Q5I0D1 GLOD4_RAT 4.00E-136 GO:0005739 mitochondrion IPR025870; Glyoxalase domain-containing protein 4 Glod4 Rattus norvegicus (Rat) TR32359_c1_g3_i5 P0AC82 LGUL_ECO57 7.00E-12 GO:0004462; GO:0046872 lactoylglutathione lyase activity; metal ion binding IPR004360; IPR004361; IPR018146; Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2. Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) gloA Z2669 ECs2360 Escherichia coli O157:H7 TR32359_c1_g3_i7 Q948T6 LGUL_ORYSJ 6.00E-24 GO:0004462; GO:0046872 lactoylglutathione lyase activity; metal ion binding IPR004360; IPR004361; IPR018146; Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2. Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Allergen Glb33) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (PP33) (S-D-lactoylglutathione methylglyoxal lyase) (allergen Ory s ?) GLX-I Os08g0191700 LOC_Os08g09250 OSJNBa0056O06.9-1 Oryza sativa subsp. japonica (Rice) TR32362_c0_g1_i1 Q04281 HOX71_XENLA 3.00E-54 GO:0007275; GO:0005634; GO:0043565; GO:0003700 multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein XHOX-7.1 (Fragment) Xenopus laevis (African clawed frog) TR32365_c0_g1_i1 Q94B74 NUDT2_ARATH 5.00E-41 GO:0047631; GO:0051287; GO:0000210; GO:0046872; GO:0006979 ADP-ribose diphosphatase activity; NAD binding; NAD+ diphosphatase activity; metal ion binding; response to oxidative stress IPR003293; IPR000086; IPR015797; Nudix hydrolase 2 (AtNUDT2) (EC 3.6.1.-) (ADP-ribose pyrophosphatase) (EC 3.6.1.13) (NADH pyrophosphatase) (EC 3.6.1.22) NUDT2 NUDX2 At5g47650 MNJ7.24 Arabidopsis thaliana (Mouse-ear cress) TR32365_c0_g1_i3 P53370 NUDT6_HUMAN 7.00E-87 GO:0008083; GO:0016787; GO:0005739; GO:0005634 growth factor activity; hydrolase activity; mitochondrion; nucleus IPR003293; IPR020084; IPR000086; IPR015797; Nucleoside diphosphate-linked moiety X motif 6 (Nudix motif 6) (EC 3.6.1.-) (Antisense basic fibroblast growth factor) (Protein GFG) NUDT6 FGF2AS Homo sapiens (Human) TR32367_c2_g1_i2 Q9BXJ4 C1QT3_HUMAN 4.00E-09 GO:0035356; GO:0005581; GO:0005615; GO:0045444; GO:0042593; GO:0042347; GO:0010629; GO:0045721; GO:0050728; GO:1900165; GO:0071638; GO:0070374; GO:0070165; GO:0050715; GO:0051897; GO:0070206 cellular triglyceride homeostasis; collagen; extracellular space; fat cell differentiation; glucose homeostasis; negative regulation of NF-kappaB import into nucleus; negative regulation of gene expression; negative regulation of gluconeogenesis; negative regulation of inflammatory response; negative regulation of interleukin-6 secretion; negative regulation of monocyte chemotactic protein-1 production; positive regulation of ERK1 and ERK2 cascade; positive regulation of adiponectin secretion; positive regulation of cytokine secretion; positive regulation of protein kinase B signaling cascade; protein trimerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) TR32367_c3_g5_i4 Q9NRA2 S17A5_HUMAN 5.00E-43 GO:0006865; GO:0030054; GO:0005887; GO:0005765; GO:0015136; GO:0015739; GO:0005351; GO:0030672 amino acid transport; cell junction; integral to plasma membrane; lysosomal membrane; sialic acid transmembrane transporter activity; sialic acid transport; sugar:hydrogen symporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) TR32368_c0_g1_i1 Q4ZJM9 C1QL4_MOUSE 2.00E-12 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) TR32368_c0_g1_i2 Q8R066 C1QT4_MOUSE 6.00E-06 GO:0005615 extracellular space IPR001073; IPR008983; Complement C1q tumor necrosis factor-related protein 4 C1qtnf4 Mus musculus (Mouse) TR32368_c0_g1_i3 Q9ESN4 C1QL3_MOUSE 2.00E-14 GO:0005581; GO:0005576; GO:0050807 collagen; extracellular region; regulation of synapse organization IPR001073; IPR008160; IPR008983; Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13) (CTRP13) (Gliacolin) C1ql3 C1ql Ctrp13 Mus musculus (Mouse) TR32369_c1_g1_i1 Q8N6T7 SIR6_HUMAN 6.00E-117 GO:0003956; GO:0003950; GO:0070403; GO:0046969; GO:0005724; GO:0005654; GO:0006471; GO:0010569; GO:0008270 P01106; Q04206 NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity (H3-K9 specific); nuclear telomeric heterochromatin; nucleoplasm; protein ADP-ribosylation; regulation of double-strand break repair via homologous recombination; zinc ion binding IPR003000; IPR026590; NAD-dependent protein deacetylase sirtuin-6 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 6) (SIR2-like protein 6) SIRT6 SIR2L6 Homo sapiens (Human) TR32373_c3_g1_i2 Q9NBX4 RTXE_DROME 1.00E-14 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR32375_c0_g1_i1 Q28GQ2 MECR_XENTR 3.00E-113 GO:0006633; GO:0005739; GO:0039020; GO:0019166; GO:0008270 fatty acid biosynthetic process; mitochondrion; pronephric nephron tubule development; trans-2-enoyl-CoA reductase (NADPH) activity; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; "Trans-2-enoyl-CoA reductase, mitochondrial (EC 1.3.1.38)" mecr TEgg103l11.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR32378_c0_g1_i1 O46629 ECHB_BOVIN 0 GO:0003988; GO:0005783; GO:0006635; GO:0016509; GO:0005743; GO:0042645; GO:0005741 acetyl-CoA C-acyltransferase activity; endoplasmic reticulum; fatty acid beta-oxidation; long-chain-3-hydroxyacyl-CoA dehydrogenase activity; mitochondrial inner membrane; mitochondrial nucleoid; mitochondrial outer membrane IPR002155; IPR016039; IPR016038; IPR020615; IPR020610; IPR020617; IPR020613; IPR020616; Lipid metabolism; fatty acid beta-oxidation. "Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)]" HADHB Bos taurus (Bovine) TR32379_c0_g1_i3 Q7ZUG0 RUXE_DANRE 3.00E-51 GO:0003723; GO:0000398; GO:0005681 "RNA binding; mRNA splicing, via spliceosome; spliceosomal complex" IPR010920; IPR001163; IPR006649; IPR027078; Small nuclear ribonucleoprotein E (snRNP-E) (Sm protein E) (Sm-E) (SmE) snrpe zgc:56682 Danio rerio (Zebrafish) (Brachydanio rerio) TR32381_c4_g1_i1 Q05654 RTF21_SCHPO 2.00E-84 TR32382_c0_g2_i1 Q675A5 PAG15_RAT 9.00E-07 GO:0008374; GO:0047499; GO:0006672; GO:0005576; GO:0006631; GO:0005764; GO:0005739; GO:0046470 O-acyltransferase activity; calcium-independent phospholipase A2 activity; ceramide metabolic process; extracellular region; fatty acid metabolic process; lysosome; mitochondrion; phosphatidylcholine metabolic process IPR003386; Group XV phospholipase A2 (EC 2.3.1.-) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) Pla2g15 Lypla3 Rattus norvegicus (Rat) TR32385_c2_g1_i1 O14718 OPSX_HUMAN 1.00E-09 GO:0004930; GO:0005887; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to plasma membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR002962; IPR027430; Visual pigment-like receptor peropsin RRH Homo sapiens (Human) TR32385_c3_g1_i3 Q9UBK9 UXT_HUMAN 1.00E-43 GO:0001106; GO:0048487; GO:0005813; GO:0051297; GO:0003682; GO:0005737; GO:0008017; GO:0047497; GO:0005634; GO:0016272; GO:0006457 Q03112; Q04206; Q0D2N8 RNA polymerase II transcription corepressor activity; beta-tubulin binding; centrosome; centrosome organization; chromatin binding; cytoplasm; microtubule binding; mitochondrion transport along microtubule; nucleus; prefoldin complex; protein folding IPR003994; IPR009053; IPR004127; Protein UXT (Androgen receptor trapped clone 27 protein) (ART-27) (Ubiquitously expressed transcript protein) UXT HSPC024 Homo sapiens (Human) TR32385_c3_g2_i1 B0RS12 Y1894_XANCB 1.00E-96 IPR003846; UPF0061 protein xcc-b100_1894 xcc-b100_1894 Xanthomonas campestris pv. campestris (strain B100) TR32387_c2_g1_i1 P40871 DHBE_BACSU 3.00E-22 GO:0008668; GO:0005524; GO:0005737; GO:0016874; GO:0019290 "(2,3-dihydroxybenzoyl)adenylate synthase activity; ATP binding; cytoplasm; ligase activity; siderophore biosynthetic process" IPR025110; IPR020845; IPR000873; IPR011963; Siderophore biosynthesis; bacillibactin biosynthesis. "2,3-dihydroxybenzoate-AMP ligase (EC 6.3.2.-) (Dihydroxybenzoic acid-activating enzyme)" dhbE entE BSU31980 Bacillus subtilis (strain 168) TR32387_c2_g1_i2 Q5R9G9 ACSF2_PONAB 5.00E-26 GO:0005524; GO:0006631; GO:0016874; GO:0005739 ATP binding; fatty acid metabolic process; ligase activity; mitochondrion IPR025110; IPR020845; IPR000873; "Acyl-CoA synthetase family member 2, mitochondrial (EC 6.2.1.-)" ACSF2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR32388_c1_g1_i2 Q9DBT3 CCD97_MOUSE 1.00E-32 IPR018613; Coiled-coil domain-containing protein 97 Ccdc97 D7Ertd462e Mus musculus (Mouse) TR32391_c1_g1_i1 P39087 GRIK2_MOUSE 0 GO:0001662; GO:0030054; GO:0006874; GO:0005234; GO:0016021; GO:0006886; GO:0004970; GO:0015277; GO:0032983; GO:0043524; GO:0051967; GO:0043025; GO:0050806; GO:0045211; GO:0042734; GO:0019228; GO:0060079; GO:0060080; GO:0048169; GO:0048172; GO:0045202; GO:0035249 "behavioral fear response; cell junction; cellular calcium ion homeostasis; extracellular-glutamate-gated ion channel activity; integral to membrane; intracellular protein transport; ionotropic glutamate receptor activity; kainate selective glutamate receptor activity; kainate selective glutamate receptor complex; negative regulation of neuron apoptotic process; negative regulation of synaptic transmission, glutamatergic; neuronal cell body; positive regulation of synaptic transmission; postsynaptic membrane; presynaptic membrane; regulation of action potential in neuron; regulation of excitatory postsynaptic membrane potential; regulation of inhibitory postsynaptic membrane potential; regulation of long-term neuronal synaptic plasticity; regulation of short-term neuronal synaptic plasticity; synapse; synaptic transmission, glutamatergic" IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; "Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6) (Glutamate receptor beta-2) (GluR beta-2)" Grik2 Glur6 Mus musculus (Mouse) TR32393_c2_g1_i2 P11712 CP2C9_HUMAN 8.00E-89 GO:0052741; GO:0018675; GO:0018676; GO:0034875; GO:0008144; GO:0005789; GO:0019373; GO:0042738; GO:0020037; GO:0005506; GO:0016098; GO:0097267; GO:0070989; GO:0008395; GO:0008202; GO:0019627; GO:0006805 (R)-limonene 6-monooxygenase activity; (S)-limonene 6-monooxygenase activity; (S)-limonene 7-monooxygenase activity; caffeine oxidase activity; drug binding; endoplasmic reticulum membrane; epoxygenase P450 pathway; exogenous drug catabolic process; heme binding; iron ion binding; monoterpenoid metabolic process; omega-hydroxylase P450 pathway; oxidative demethylation; steroid hydroxylase activity; steroid metabolic process; urea metabolic process; xenobiotic metabolic process IPR001128; IPR017972; IPR002401; Cytochrome P450 2C9 (EC 1.14.13.-) ((R)-limonene 6-monooxygenase) (EC 1.14.13.80) ((S)-limonene 6-monooxygenase) (EC 1.14.13.48) ((S)-limonene 7-monooxygenase) (EC 1.14.13.49) (CYPIIC9) (Cytochrome P-450MP) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (Cytochrome P450 PB-1) (S-mephenytoin 4-hydroxylase) CYP2C9 CYP2C10 Homo sapiens (Human) TR32394_c1_g9_i1 Q29599 OAS1_PIG 4.00E-18 GO:0001730; GO:0005524; GO:0005737; GO:0051607; GO:0003725; GO:0005783; GO:0005576; GO:0045087; GO:0046872; GO:0005739; GO:0045071; GO:0005634; GO:0006164 2'-5'-oligoadenylate synthetase activity; ATP binding; cytoplasm; defense response to virus; double-stranded RNA binding; endoplasmic reticulum; extracellular region; innate immune response; metal ion binding; mitochondrion; negative regulation of viral genome replication; nucleus; purine nucleotide biosynthetic process IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 1 ((2-5')oligo(A) synthase 1) (2-5A synthase 1) (EC 2.7.7.84) (p42 OAS) OAS1 Sus scrofa (Pig) TR32396_c0_g1_i1 Q2L969 MTX2_PIG 3.00E-76 GO:0005741; GO:0006626 mitochondrial outer membrane; protein targeting to mitochondrion IPR010987; IPR019564; Metaxin-2 (Mitochondrial outer membrane import complex protein 2) MTX2 Sus scrofa (Pig) TR32396_c0_g1_i2 P34599 MTX2_CAEEL 2.00E-51 GO:0005741; GO:0005739; GO:0006626 mitochondrial outer membrane; mitochondrion; protein targeting to mitochondrion IPR010987; IPR019564; Metaxin-2 homolog (Mitochondrial outer membrane import complex protein 2) mtx-2 ZC97.1 Caenorhabditis elegans TR32396_c0_g1_i3 Q9VHB6 MTX1_DROME 9.00E-19 GO:0016021; GO:0005741; GO:0006626 integral to membrane; mitochondrial outer membrane; protein targeting to mitochondrion IPR010987; IPR017410; IPR019564; Metaxin-1 homolog (Mitochondrial outer membrane import complex protein 1) CG9393 Drosophila melanogaster (Fruit fly) TR32397_c0_g1_i1 Q06478 PA11_DOLMA 9.00E-29 GO:0052740; GO:0005576; GO:0016042; GO:0008970; GO:0052739; GO:0004623 1-acyl-2-lysophosphatidylserine acylhydrolase activity; extracellular region; lipid catabolic process; phosphatidylcholine 1-acylhydrolase activity; phosphatidylserine 1-acylhydrolase activity; phospholipase A2 activity IPR002334; IPR000734; IPR013818; Phospholipase A1 1 (EC 3.1.1.32) (EC 3.1.1.4) (Allergen Dol m I) (allergen Dol m 1.01) (Fragment) Dolichovespula maculata (Bald-faced hornet) (Vespula maculata) TR32397_c0_g1_i2 P54315 LIPR1_HUMAN 1.00E-85 GO:0005509; GO:0005576; GO:0006629; GO:0004806 calcium ion binding; extracellular region; lipid metabolic process; triglyceride lipase activity IPR000734; IPR008976; IPR013818; IPR002331; IPR016272; IPR001024; Inactive pancreatic lipase-related protein 1 (PL-RP1) PNLIPRP1 PLRP1 Homo sapiens (Human) TR32398_c0_g1_i1 Q24537 HMG2_DROME 2.00E-59 GO:0008301; GO:0006268; GO:0006338; GO:0035218; GO:0017055; GO:0008348; GO:0005634; GO:0005700; GO:0043388; GO:0007379; GO:0003697 "DNA binding, bending; DNA unwinding involved in DNA replication; chromatin remodeling; leg disc development; negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; negative regulation of antimicrobial humoral response; nucleus; polytene chromosome; positive regulation of DNA binding; segment specification; single-stranded DNA binding" IPR009071; IPR017967; High mobility group protein DSP1 (Protein dorsal switch 1) Dsp1 ssrp2 CG12223 Drosophila melanogaster (Fruit fly) TR32398_c0_g1_i2 Q32L34 HMGB4_BOVIN 8.00E-31 GO:0003677; GO:0005694; GO:0005634 DNA binding; chromosome; nucleus IPR009071; High mobility group protein B4 HMGB4 Bos taurus (Bovine) TR32398_c0_g1_i3 Q24537 HMG2_DROME 2.00E-59 GO:0008301; GO:0006268; GO:0006338; GO:0035218; GO:0017055; GO:0008348; GO:0005634; GO:0005700; GO:0043388; GO:0007379; GO:0003697 "DNA binding, bending; DNA unwinding involved in DNA replication; chromatin remodeling; leg disc development; negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; negative regulation of antimicrobial humoral response; nucleus; polytene chromosome; positive regulation of DNA binding; segment specification; single-stranded DNA binding" IPR009071; IPR017967; High mobility group protein DSP1 (Protein dorsal switch 1) Dsp1 ssrp2 CG12223 Drosophila melanogaster (Fruit fly) TR32399_c0_g2_i1 Q8R4V5 OIT3_MOUSE 2.00E-09 GO:0005635 nuclear envelope IPR000742; IPR001507; Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein) Oit3 Lzp Mus musculus (Mouse) TR32399_c0_g2_i2 P19218 GP2_RAT 8.00E-09 GO:0031225; GO:0005576; GO:0005886 anchored to membrane; extracellular region; plasma membrane IPR001507; IPR017977; Pancreatic secretory granule membrane major glycoprotein GP2 (Glycoprotein 80) (gp80) (Pancreatic zymogen granule membrane protein GP-2) Gp2 Rattus norvegicus (Rat) TR32401_c0_g1_i1 Q91X20 ASH2L_MOUSE 4.00E-143 GO:0071339; GO:0048188; GO:0051568; GO:0042800; GO:0046872; GO:0008284; GO:0045944; GO:0006974; GO:0043627; GO:0044212; GO:0006351 Q8BX09 "MLL1 complex; Set1C/COMPASS complex; histone H3-K4 methylation; histone methyltransferase activity (H3-K4 specific); metal ion binding; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; response to estrogen stimulus; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR001870; IPR008985; IPR018355; IPR003877; Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) Ash2l Mus musculus (Mouse) TR32404_c0_g1_i2 Q2KIS3 UBL7_BOVIN 2.00E-35 IPR009060; IPR015940; IPR000449; IPR015496; IPR000626; Ubiquitin-like protein 7 UBL7 Bos taurus (Bovine) TR32405_c0_g1_i1 Q7Z6J9 SEN54_HUMAN 9.00E-37 GO:0006397; GO:0005730; GO:0006388 "mRNA processing; nucleolus; tRNA splicing, via endonucleolytic cleavage and ligation" IPR024337; IPR024336; tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54) TSEN54 SEN54 Homo sapiens (Human) TR32405_c0_g1_i3 Q7Z6J9 SEN54_HUMAN 3.00E-38 GO:0006397; GO:0005730; GO:0006388 "mRNA processing; nucleolus; tRNA splicing, via endonucleolytic cleavage and ligation" IPR024337; IPR024336; tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54) TSEN54 SEN54 Homo sapiens (Human) TR32405_c1_g1_i1 Q6NXH8 MET25_MOUSE 2.00E-19 GO:0008168 methyltransferase activity IPR025714; Methyltransferase-like protein 25 (EC 2.1.1.-) Mettl25 Mus musculus (Mouse) TR32405_c1_g1_i2 P05388 RLA0_HUMAN 4.00E-131 GO:0003723; GO:0006614; GO:0022625; GO:0019048; GO:0000184; GO:0005634; GO:0042254; GO:0003735; GO:0006414; GO:0006413; GO:0006415; GO:0019083 O95793 "RNA binding; SRP-dependent cotranslational protein targeting to membrane; cytosolic large ribosomal subunit; modulation by virus of host morphology or physiology; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus; ribosome biogenesis; structural constituent of ribosome; translational elongation; translational initiation; translational termination; viral transcription" IPR001790; IPR001813; 60S acidic ribosomal protein P0 (60S ribosomal protein L10E) RPLP0 Homo sapiens (Human) TR32405_c2_g1_i1 Q96FB5 RRNAD_HUMAN 8.00E-11 GO:0016021; GO:0000179; GO:0031167 "integral to membrane; rRNA (adenine-N6,N6-)-dimethyltransferase activity; rRNA methylation" IPR025714; IPR020596; Protein RRNAD1 (Ribosomal RNA adenine dimethylase domain-containing protein 1) RRNAD1 C1orf66 CGI-41 Homo sapiens (Human) TR32405_c2_g1_i6 Q5E9V4 RRNAD_BOVIN 6.00E-12 GO:0016021; GO:0000179; GO:0031167 "integral to membrane; rRNA (adenine-N6,N6-)-dimethyltransferase activity; rRNA methylation" IPR025714; IPR020596; Protein RRNAD1 RRNAD1 Bos taurus (Bovine) TR32405_c2_g1_i7 Q8BZG5 RRNAD_MOUSE 8.00E-12 GO:0016021 integral to membrane IPR025714; Protein RRNAD1 Rrnad1 Mus musculus (Mouse) TR32405_c2_g2_i1 B0BLZ5 THEM6_XENTR 2.00E-42 GO:0005576 extracellular region Protein THEM6 them6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR32406_c0_g1_i1 Q08CA1 GDPP1_DANRE 9.00E-87 GO:0080048; GO:0005737; GO:0006006; GO:0005085; GO:0016787; GO:0000166; GO:0016779 GDP-D-glucose phosphorylase activity; cytoplasm; glucose metabolic process; guanyl-nucleotide exchange factor activity; hydrolase activity; nucleotide binding; nucleotidyltransferase activity IPR026506; GDP-D-glucose phosphorylase 1 (EC 2.7.7.78) gdpgp1 zgc:153343 Danio rerio (Zebrafish) (Brachydanio rerio) TR32406_c0_g1_i2 Q9FLP9 GGAP2_ARATH 5.00E-45 GO:0080048; GO:0019853; GO:0005737; GO:0010475; GO:0005085; GO:0016787; GO:0000166; GO:0005634; GO:0080046; GO:0009753; GO:0010193 O64511-2 GDP-D-glucose phosphorylase activity; L-ascorbic acid biosynthetic process; cytoplasm; galactose-1-phosphate guanylyltransferase (GDP) activity; guanyl-nucleotide exchange factor activity; hydrolase activity; nucleotide binding; nucleus; quercetin 4'-O-glucosyltransferase activity; response to jasmonic acid stimulus; response to ozone Cofactor biosynthesis; L-ascorbate biosynthesis via GDP-alpha-D-mannose pathway; L-ascorbate from GDP-alpha-D-mannose: step 2/5. GDP-L-galactose phosphorylase 2 (EC 2.7.7.69) (Protein VITAMIN C DEFECTIVE 5) VTC5 VTC2L At5g55120 MCO15.7 Arabidopsis thaliana (Mouse-ear cress) TR32407_c0_g1_i2 A7SLC8 NAT9_NEMVE 4.00E-67 GO:0008080 N-acetyltransferase activity IPR016181; IPR000182; N-acetyltransferase 9-like protein (EC 2.3.1.-) nat9 v1g171834 Nematostella vectensis (Starlet sea anemone) TR32408_c3_g2_i1 Q5R9A7 GP155_PONAB 4.00E-23 GO:0016021; GO:0035556; GO:0055085 integral to membrane; intracellular signal transduction; transmembrane transport IPR004776; IPR000591; IPR011991; Integral membrane protein GPR155 GPR155 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR32408_c3_g2_i2 Q5R9A7 GP155_PONAB 3.00E-24 GO:0016021; GO:0035556; GO:0055085 integral to membrane; intracellular signal transduction; transmembrane transport IPR004776; IPR000591; IPR011991; Integral membrane protein GPR155 GPR155 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR32408_c5_g1_i1 B4F7A1 LYRM7_RAT 3.00E-19 GO:0005759 mitochondrial matrix IPR008011; Complex III assembly factor LYRM7 (LYR motif-containing protein 7) Lyrm7 MZM1L Rattus norvegicus (Rat) TR32409_c1_g5_i1 Q91YE3 EGLN1_MOUSE 9.00E-88 GO:0031418; GO:0055008; GO:0005737; GO:0060347; GO:0005506; GO:0060711; GO:0043433; GO:0005634; GO:0032364; GO:0031545; GO:0018401; GO:0045765; GO:0001666; GO:0071731; GO:0060412 L-ascorbic acid binding; cardiac muscle tissue morphogenesis; cytoplasm; heart trabecula formation; iron ion binding; labyrinthine layer development; negative regulation of sequence-specific DNA binding transcription factor activity; nucleus; oxygen homeostasis; peptidyl-proline 4-dioxygenase activity; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; regulation of angiogenesis; response to hypoxia; response to nitric oxide; ventricular septum morphogenesis IPR005123; IPR006620; IPR002893; Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20) Egln1 Mus musculus (Mouse) TR32410_c0_g1_i1 O77245 E75_METEN 2.00E-35 GO:0005634; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Nuclear hormone receptor E75 (Nuclear receptor subfamily 1 group D member 3) E75 NR1D3 Metapenaeus ensis (Greasyback shrimp) (Sand shrimp) TR32412_c2_g1_i1 Q8VCT3 AMPB_MOUSE 2.00E-119 GO:0004177; GO:0005576; GO:0005615; GO:0019370; GO:0008237; GO:0005886; GO:0006508; GO:0008270 aminopeptidase activity; extracellular region; extracellular space; leukotriene biosynthetic process; metallopeptidase activity; plasma membrane; proteolysis; zinc ion binding IPR016024; IPR015571; IPR001930; IPR015211; IPR014782; Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) (Cytosol aminopeptidase IV) Rnpep Mus musculus (Mouse) TR32412_c2_g1_i2 P09960 LKHA4_HUMAN 0 GO:0004177; GO:0019369; GO:0005829; GO:0004301; GO:0006954; GO:0019370; GO:0004463; GO:0008237; GO:0005634; GO:0043171; GO:0006508; GO:0008270 P01241; P23508 aminopeptidase activity; arachidonic acid metabolic process; cytosol; epoxide hydrolase activity; inflammatory response; leukotriene biosynthetic process; leukotriene-A4 hydrolase activity; metallopeptidase activity; nucleus; peptide catabolic process; proteolysis; zinc ion binding IPR016024; IPR012777; IPR001930; IPR015211; IPR014782; Lipid metabolism; leukotriene B4 biosynthesis. Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) LTA4H LTA4 Homo sapiens (Human) TR32412_c2_g1_i3 P09960 LKHA4_HUMAN 0 GO:0004177; GO:0019369; GO:0005829; GO:0004301; GO:0006954; GO:0019370; GO:0004463; GO:0008237; GO:0005634; GO:0043171; GO:0006508; GO:0008270 P01241; P23508 aminopeptidase activity; arachidonic acid metabolic process; cytosol; epoxide hydrolase activity; inflammatory response; leukotriene biosynthetic process; leukotriene-A4 hydrolase activity; metallopeptidase activity; nucleus; peptide catabolic process; proteolysis; zinc ion binding IPR016024; IPR012777; IPR001930; IPR015211; IPR014782; Lipid metabolism; leukotriene B4 biosynthesis. Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) LTA4H LTA4 Homo sapiens (Human) TR32412_c2_g1_i4 Q97VF1 APE1_SULSO 4.00E-09 GO:0004177; GO:0005737; GO:0008237; GO:0006508; GO:0008270 aminopeptidase activity; cytoplasm; metallopeptidase activity; proteolysis; zinc ion binding IPR024571; IPR001930; IPR014782; Probable aminopeptidase 1 (EC 3.4.11.-) ape1 SSO2675 C30_037 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) TR32413_c2_g1_i2 Q29RY7 FGL2_BOVIN 5.00E-11 GO:0009986; GO:0005576; GO:0016504 cell surface; extracellular region; peptidase activator activity IPR014716; IPR014715; IPR002181; IPR020837; Fibroleukin (Fibrinogen-like protein 2) FGL2 Bos taurus (Bovine) TR32413_c3_g2_i1 O43156 TTI1_HUMAN 4.00E-159 GO:0031931; GO:0031932; GO:0005737; GO:0032006 Q13315; Q13535; Q9Y4R8 TORC1 complex; TORC2 complex; cytoplasm; regulation of TOR signaling cascade IPR011989; IPR016024; IPR016441; TELO2-interacting protein 1 homolog (Protein SMG10) TTI1 KIAA0406 SMG10 Homo sapiens (Human) TR32413_c3_g2_i3 O94600 TTI1_SCHPO 5.00E-12 GO:0070209; GO:0005737 ASTRA complex; cytoplasm IPR016024; IPR016441; TEL2-interacting protein 1 tti1 SPCC622.13c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR32413_c3_g2_i5 O43156 TTI1_HUMAN 4.00E-159 GO:0031931; GO:0031932; GO:0005737; GO:0032006 Q13315; Q13535; Q9Y4R8 TORC1 complex; TORC2 complex; cytoplasm; regulation of TOR signaling cascade IPR011989; IPR016024; IPR016441; TELO2-interacting protein 1 homolog (Protein SMG10) TTI1 KIAA0406 SMG10 Homo sapiens (Human) TR32413_c5_g1_i1 E2IYB3 FCNV1_VARKO 1.00E-23 GO:0005576 extracellular region IPR008160; IPR014716; IPR002181; Veficolin-1 (Fragment) Varanus komodoensis (Komodo dragon) TR32414_c0_g2_i2 A7RJI7 CCZ1_NEMVE 2.00E-113 IPR013176; Vacuolar fusion protein CCZ1 homolog v1g238755 Nematostella vectensis (Starlet sea anemone) TR32415_c2_g1_i1 Q7Z4H7 HAUS6_HUMAN 9.00E-31 GO:0070652; GO:0051301; GO:0005813; GO:0051297; GO:0005737; GO:0005874; GO:0007067; GO:0005634; GO:0005819; GO:0051225 HAUS complex; cell division; centrosome; centrosome organization; cytoplasm; microtubule; mitosis; nucleus; spindle; spindle assembly IPR026797; IPR028163; HAUS augmin-like complex subunit 6 HAUS6 DGT6 FAM29A KIAA1574 Homo sapiens (Human) TR32415_c2_g1_i3 Q7Z4H7 HAUS6_HUMAN 9.00E-31 GO:0070652; GO:0051301; GO:0005813; GO:0051297; GO:0005737; GO:0005874; GO:0007067; GO:0005634; GO:0005819; GO:0051225 HAUS complex; cell division; centrosome; centrosome organization; cytoplasm; microtubule; mitosis; nucleus; spindle; spindle assembly IPR026797; IPR028163; HAUS augmin-like complex subunit 6 HAUS6 DGT6 FAM29A KIAA1574 Homo sapiens (Human) TR32417_c0_g3_i2 Q9DDN6 NPY2R_CHICK 2.00E-51 GO:0003214; GO:0016021; GO:0004983; GO:0003151; GO:0005886 cardiac left ventricle morphogenesis; integral to membrane; neuropeptide Y receptor activity; outflow tract morphogenesis; plasma membrane IPR000276; IPR017452; IPR001358; IPR000611; Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor) (Y2 receptor) NPY2R Gallus gallus (Chicken) TR3242_c0_g1_i1 Q90Z10 RL13_DANRE 1.00E-89 GO:0051726; GO:0005840; GO:0003735; GO:0006412 regulation of cell cycle; ribosome; structural constituent of ribosome; translation IPR001380; IPR018256; 60S ribosomal protein L13 rpl13 Danio rerio (Zebrafish) (Brachydanio rerio) TR32420_c6_g2_i1 Q86WV6 TM173_HUMAN 3.00E-10 GO:0005794; GO:0002218; GO:0006915; GO:0071360; GO:0035458; GO:0061507; GO:0035438; GO:0030659; GO:0051607; GO:0005789; GO:0045087; GO:0016021; GO:0032608; GO:0005741; GO:0048471; GO:0005777; GO:0005886; GO:0002230; GO:0032092; GO:0033160; GO:0042993; GO:0045944; GO:0032481; GO:0042803; GO:0019901; GO:0008134 Itself; P27958; Q99IB8; Q96A33; P39656; Q16666; P51617; O94822; Q7Z434; Q96N66; O95470; P42226; P46977; O15260; Q9UHD2 "Golgi apparatus; activation of innate immune response; apoptotic process; cellular response to exogenous dsRNA; cellular response to interferon-beta; cyclic-GMP-AMP binding; cyclic-di-GMP binding; cytoplasmic vesicle membrane; defense response to virus; endoplasmic reticulum membrane; innate immune response; integral to membrane; interferon-beta production; mitochondrial outer membrane; perinuclear region of cytoplasm; peroxisome; plasma membrane; positive regulation of defense response to virus by host; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of type I interferon production; protein homodimerization activity; protein kinase binding; transcription factor binding" Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173) TMEM173 ERIS MITA STING Homo sapiens (Human) TR32421_c2_g1_i1 Q86AV9 PLDG_DICDI 2.00E-26 GO:0006507; GO:0007155; GO:0005576; GO:0004621; GO:0008305; GO:0004630 GPI anchor release; cell adhesion; extracellular region; glycosylphosphatidylinositol phospholipase D activity; integrin complex; phospholipase D activity IPR013519; IPR000413; Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D) (Phospholipase G) pldG DDB_G0276919 Dictyostelium discoideum (Slime mold) TR32421_c2_g2_i1 P80109 PHLD_BOVIN 1.00E-49 GO:0006507; GO:0002042; GO:0071277; GO:0071397; GO:0035690; GO:0071467; GO:0071401; GO:0002062; GO:0002430; GO:0005737; GO:0005615; GO:0004621; GO:0034364; GO:0008286; GO:0043231; GO:0008285; GO:0010897; GO:0001503; GO:0046470; GO:0010694; GO:0043065; GO:0045919; GO:0010595; GO:0010907; GO:0010983; GO:0035774; GO:0051044; GO:0010867; GO:0005578; GO:1900076; GO:0009749; GO:0017080; GO:0070633 GPI anchor release; cell migration involved in sprouting angiogenesis; cellular response to calcium ion; cellular response to cholesterol; cellular response to drug; cellular response to pH; cellular response to triglyceride; chondrocyte differentiation; complement receptor mediated signaling pathway; cytoplasm; extracellular space; glycosylphosphatidylinositol phospholipase D activity; high-density lipoprotein particle; insulin receptor signaling pathway; intracellular membrane-bounded organelle; negative regulation of cell proliferation; negative regulation of triglyceride catabolic process; ossification; phosphatidylcholine metabolic process; positive regulation of alkaline phosphatase activity; positive regulation of apoptotic process; positive regulation of cytolysis; positive regulation of endothelial cell migration; positive regulation of glucose metabolic process; positive regulation of high-density lipoprotein particle clearance; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of membrane protein ectodomain proteolysis; positive regulation of triglyceride biosynthetic process; proteinaceous extracellular matrix; regulation of cellular response to insulin stimulus; response to glucose stimulus; sodium channel regulator activity; transepithelial transport IPR013517; IPR001028; IPR013519; Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycoprotein phospholipase D) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D) GPLD1 PIGPLD Bos taurus (Bovine) TR32421_c2_g3_i1 P47014 YJN2_YEAST 1.00E-07 GO:0016021; GO:0016020 integral to membrane; membrane IPR013519; Uncharacterized protein YJL132W YJL132W J0678 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR32421_c6_g1_i1 P80109 PHLD_BOVIN 1.00E-34 GO:0006507; GO:0002042; GO:0071277; GO:0071397; GO:0035690; GO:0071467; GO:0071401; GO:0002062; GO:0002430; GO:0005737; GO:0005615; GO:0004621; GO:0034364; GO:0008286; GO:0043231; GO:0008285; GO:0010897; GO:0001503; GO:0046470; GO:0010694; GO:0043065; GO:0045919; GO:0010595; GO:0010907; GO:0010983; GO:0035774; GO:0051044; GO:0010867; GO:0005578; GO:1900076; GO:0009749; GO:0017080; GO:0070633 GPI anchor release; cell migration involved in sprouting angiogenesis; cellular response to calcium ion; cellular response to cholesterol; cellular response to drug; cellular response to pH; cellular response to triglyceride; chondrocyte differentiation; complement receptor mediated signaling pathway; cytoplasm; extracellular space; glycosylphosphatidylinositol phospholipase D activity; high-density lipoprotein particle; insulin receptor signaling pathway; intracellular membrane-bounded organelle; negative regulation of cell proliferation; negative regulation of triglyceride catabolic process; ossification; phosphatidylcholine metabolic process; positive regulation of alkaline phosphatase activity; positive regulation of apoptotic process; positive regulation of cytolysis; positive regulation of endothelial cell migration; positive regulation of glucose metabolic process; positive regulation of high-density lipoprotein particle clearance; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of membrane protein ectodomain proteolysis; positive regulation of triglyceride biosynthetic process; proteinaceous extracellular matrix; regulation of cellular response to insulin stimulus; response to glucose stimulus; sodium channel regulator activity; transepithelial transport IPR013517; IPR001028; IPR013519; Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycoprotein phospholipase D) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D) GPLD1 PIGPLD Bos taurus (Bovine) TR32421_c6_g1_i2 P26007 ITA6_CHICK 3.00E-06 GO:0007155; GO:0008305; GO:0007229; GO:0046872 cell adhesion; integrin complex; integrin-mediated signaling pathway; metal ion binding IPR013517; IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha-6 (VLA-6) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain] ITGA6 Gallus gallus (Chicken) TR32424_c0_g1_i1 Q9CV28 F188A_MOUSE 9.00E-133 GO:0006915; GO:0005509; GO:0031965 apoptotic process; calcium ion binding; nuclear membrane IPR025257; IPR011992; Protein FAM188A (Protein CARP) Fam188a Carp Mus musculus (Mouse) TR32426_c2_g2_i2 Q9BS18 APC13_HUMAN 3.00E-22 GO:0005680; GO:0051301; GO:0007067; GO:0070979 anaphase-promoting complex; cell division; mitosis; protein K11-linked ubiquitination IPR008401; Protein modification; protein ubiquitination. Anaphase-promoting complex subunit 13 (APC13) (Cyclosome subunit 13) ANAPC13 Homo sapiens (Human) TR32428_c0_g1_i1 Q57951 Y531_METJA 1.00E-07 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein MJ0531 (USP MJ0531) MJ0531 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR32431_c0_g1_i2 Q9QYG6 CP2DR_MESAU 2.00E-100 GO:0005789; GO:0020037; GO:0005506; GO:0016712 "endoplasmic reticulum membrane; heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen" IPR001128; IPR017972; IPR002401; IPR008069; Cytochrome P450 2D27 (EC 1.14.14.-) (CYPIID27) CYP2D27 Mesocricetus auratus (Golden hamster) TR32432_c2_g1_i2 Q1LWH4 FAN1_DANRE 1.00E-120 GO:0008409; GO:0017108; GO:0000724; GO:0046872; GO:0033683; GO:0005634; GO:0004528; GO:0043130 "5'-3' exonuclease activity; 5'-flap endonuclease activity; double-strand break repair via homologous recombination; metal ion binding; nucleotide-excision repair, DNA incision; nucleus; phosphodiesterase I activity; ubiquitin binding" IPR014883; Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (Myotubularin-related protein 15) fan1 mtmr15 si:ch211-163b1.2 si:ch211-201b11.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR32433_c2_g1_i2 Q62136 PTN21_MOUSE 2.00E-115 GO:0005737; GO:0005856; GO:0035335; GO:0004725 cytoplasm; cytoskeleton; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR019749; IPR019750; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; IPR000387; IPR016130; IPR014392; IPR000242; Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10) Ptpn21 Mus musculus (Mouse) TR32433_c2_g1_i3 Q9BMN8 LAR_CAEEL 4.00E-42 GO:0005912; GO:0010172; GO:0008544; GO:0007369; GO:0016021; GO:0008045; GO:0005886; GO:0035418; GO:0045202; GO:0007416; GO:0005001 adherens junction; embryonic body morphogenesis; epidermis development; gastrulation; integral to membrane; motor neuron axon guidance; plasma membrane; protein localization to synapse; synapse; synapse assembly; transmembrane receptor protein tyrosine phosphatase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase Lar-like (EC 3.1.3.48) (Protein-tyrosine phosphate 3) ptp-3 C09D8.1/C09D8.2 Caenorhabditis elegans TR32435_c2_g1_i1 Q8CFW1 ANO2_MOUSE 2.00E-65 GO:0034707; GO:0005229; GO:0005886 chloride channel complex; intracellular calcium activated chloride channel activity; plasma membrane IPR007632; Anoctamin-2 (Transmembrane protein 16B) Ano2 Tmem16b Mus musculus (Mouse) TR32435_c4_g1_i2 Q5XXA6 ANO1_HUMAN 8.00E-71 GO:0034707; GO:0005737; GO:0005229; GO:0007275; GO:0005886; GO:0042391 chloride channel complex; cytoplasm; intracellular calcium activated chloride channel activity; multicellular organismal development; plasma membrane; regulation of membrane potential IPR007632; Anoctamin-1 (Discovered on gastrointestinal stromal tumors protein 1) (Oral cancer overexpressed protein 2) (Transmembrane protein 16A) (Tumor-amplified and overexpressed sequence 2) ANO1 DOG1 ORAOV2 TAOS2 TMEM16A Homo sapiens (Human) TR32436_c1_g1_i1 P98160 PGBM_HUMAN 6.00E-08 GO:0005796; GO:0001525; GO:0005605; GO:0007420; GO:0005975; GO:0048738; GO:0060351; GO:0002062; GO:0030204; GO:0048704; GO:0001958; GO:0030198; GO:0005615; GO:0070062; GO:0006024; GO:0006027; GO:0042157; GO:0043202; GO:0046872; GO:0007603; GO:0005886; GO:0008104; GO:0001523 P35968 "Golgi lumen; angiogenesis; basal lamina; brain development; carbohydrate metabolic process; cardiac muscle tissue development; cartilage development involved in endochondral bone morphogenesis; chondrocyte differentiation; chondroitin sulfate metabolic process; embryonic skeletal system morphogenesis; endochondral ossification; extracellular matrix organization; extracellular space; extracellular vesicular exosome; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; lipoprotein metabolic process; lysosomal lumen; metal ion binding; phototransduction, visible light; plasma membrane; protein localization; retinoid metabolic process" IPR008985; IPR013320; IPR000742; IPR013032; IPR002049; IPR007110; IPR013783; IPR013098; IPR003598; IPR018031; IPR000034; IPR001791; IPR023415; IPR002172; IPR000082; Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] HSPG2 Homo sapiens (Human) TR32436_c2_g1_i1 Q90275 CADH2_DANRE 2.00E-08 GO:0060088; GO:0048331; GO:0007413; GO:0005509; GO:0010002; GO:0001502; GO:0016342; GO:0060030; GO:0035142; GO:0007398; GO:0048048; GO:0035118; GO:0060059; GO:0045198; GO:0030902; GO:0007156; GO:0016021; GO:0030901; GO:0001755; GO:0021915; GO:0001764; GO:0048471; GO:0007422; GO:0070285; GO:0036342; GO:0042734; GO:0042478; GO:0048752; GO:0001756; GO:0007416; GO:0042246 auditory receptor cell stereocilium organization; axial mesoderm structural organization; axonal fasciculation; calcium ion binding; cardioblast differentiation; cartilage condensation; catenin complex; dorsal convergence; dorsal fin morphogenesis; ectoderm development; embryonic eye morphogenesis; embryonic pectoral fin morphogenesis; embryonic retina morphogenesis in camera-type eye; establishment of epithelial cell apical/basal polarity; hindbrain development; homophilic cell adhesion; integral to membrane; midbrain development; neural crest cell migration; neural tube development; neuron migration; perinuclear region of cytoplasm; peripheral nervous system development; pigment cell development; post-anal tail morphogenesis; presynaptic membrane; regulation of eye photoreceptor cell development; semicircular canal morphogenesis; somitogenesis; synapse assembly; tissue regeneration IPR002126; IPR015919; IPR009124; IPR020894; IPR000233; IPR014868; IPR027397; Cadherin-2 (Neural cadherin) (N-cadherin) (ZNCAD) cdh2 Danio rerio (Zebrafish) (Brachydanio rerio) TR32436_c4_g1_i1 Q24298 CADE_DROME 1.00E-24 GO:0045176; GO:0007411; GO:0008013; GO:0007298; GO:0007420; GO:0035147; GO:0005509; GO:0016339; GO:0050839; GO:0030031; GO:0044331; GO:0050832; GO:0071907; GO:0030175; GO:0042078; GO:0030708; GO:0035262; GO:0007506; GO:0008258; GO:0035099; GO:0007156; GO:0005887; GO:0035160; GO:0016318; GO:0007314; GO:0030720; GO:0001748; GO:0003151; GO:0007280; GO:0004872; GO:0007435; GO:0048103; GO:0035019; GO:0005914; GO:0007370; GO:0042060; GO:0005915; GO:0045186 "apical protein localization; axon guidance; beta-catenin binding; border follicle cell migration; brain development; branch fusion, open tracheal system; calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; cell projection assembly; cell-cell adhesion mediated by cadherin; defense response to fungus; determination of digestive tract left/right asymmetry; filopodium; germ-line stem cell division; germarium-derived female germ-line cyst encapsulation; gonad morphogenesis; gonadal mesoderm development; head involution; hemocyte migration; homophilic cell adhesion; integral to plasma membrane; maintenance of epithelial integrity, open tracheal system; ommatidial rotation; oocyte anterior/posterior axis specification; oocyte localization involved in germarium-derived egg chamber formation; optic lobe placode development; outflow tract morphogenesis; pole cell migration; receptor activity; salivary gland morphogenesis; somatic stem cell division; somatic stem cell maintenance; spot adherens junction; ventral furrow formation; wound healing; zonula adherens; zonula adherens assembly" IPR002126; IPR015919; IPR020894; IPR000233; IPR027397; IPR008985; IPR013320; IPR000742; IPR013032; IPR001791; DE-cadherin (Protein shotgun) shg gp150 CG3722 Drosophila melanogaster (Fruit fly) TR32437_c0_g1_i1 P63170 DYL1_RAT 4.00E-14 GO:0008180; GO:0006915; GO:0005813; GO:0005868; GO:0005829; GO:0004857; GO:0000776; GO:0016020; GO:0005874; GO:0007017; GO:0005739; GO:0072686; GO:0003774; GO:0042326; GO:0042133; GO:0006809; GO:0030235; GO:0042803; GO:0006355; GO:0006351; GO:0006810 "COP9 signalosome; apoptotic process; centrosome; cytoplasmic dynein complex; cytosol; enzyme inhibitor activity; kinetochore; membrane; microtubule; microtubule-based process; mitochondrion; mitotic spindle; motor activity; negative regulation of phosphorylation; neurotransmitter metabolic process; nitric oxide biosynthetic process; nitric-oxide synthase regulator activity; protein homodimerization activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent; transport" IPR019763; IPR001372; "Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN)" Dynll1 Dncl1 Dnclc1 Pin Rattus norvegicus (Rat) TR32437_c0_g1_i2 Q21557 DYL2_CAEEL 2.00E-09 GO:0005737; GO:0030286; GO:0005874; GO:0007017; GO:0003774 cytoplasm; dynein complex; microtubule; microtubule-based process; motor activity IPR019763; IPR001372; "Probable dynein light chain 2, cytoplasmic" dlc-2 M18.2 Caenorhabditis elegans TR32438_c2_g1_i2 P55259 GP2_HUMAN 2.00E-07 GO:0031225; GO:0003823; GO:0002412; GO:0016324; GO:0005576 anchored to membrane; antigen binding; antigen transcytosis by M cells in mucosal-associated lymphoid tissue; apical plasma membrane; extracellular region IPR001507; IPR017977; Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) (ZAP75) GP2 Homo sapiens (Human) TR32440_c1_g1_i2 Q9I8A3 HEY1_XENLA 6.00E-54 GO:0007219; GO:0033504; GO:0072013; GO:0000122; GO:0005634; GO:0072196; GO:0043565; GO:0072082; GO:0006351 "Notch signaling pathway; floor plate development; glomus development; negative regulation of transcription from RNA polymerase II promoter; nucleus; proximal/distal pattern formation involved in pronephric nephron development; sequence-specific DNA binding; specification of proximal tubule identity; transcription, DNA-dependent" IPR011598; IPR003650; IPR018352; Hairy/enhancer-of-split related with YRPW motif protein 1 (XHey-1) (Hairy and enhancer of split-related protein 1) (Hesr-1) (Hairy-related transcription factor 1) (HRT-1) (XHRT1) (xHRT-1) (Protein xbc8) hey1 bc8 hrt1 Xenopus laevis (African clawed frog) TR32440_c1_g1_i3 Q7KM13 HEY_DROME 5.00E-57 GO:0003677; GO:0007219; GO:0045746; GO:0048664; GO:0005634; GO:0006355; GO:0006351 "DNA binding; Notch signaling pathway; negative regulation of Notch signaling pathway; neuron fate determination; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011598; IPR003650; IPR018352; Hairy/enhancer-of-split related with YRPW motif protein Hey Hesr-1 CG11194 Drosophila melanogaster (Fruit fly) TR32441_c2_g2_i1 P41413 PCSK5_RAT 2.00E-88 GO:0005794; GO:0009952; GO:0042089; GO:0007566; GO:0048566; GO:0048706; GO:0012505; GO:0005615; GO:0007507; GO:0016021; GO:0001822; GO:0035108; GO:0042277; GO:0043043; GO:0016486; GO:0006508; GO:0002001; GO:0030323; GO:0030141; GO:0004252; GO:0006465 Golgi apparatus; anterior/posterior pattern specification; cytokine biosynthetic process; embryo implantation; embryonic digestive tract development; embryonic skeletal system development; endomembrane system; extracellular space; heart development; integral to membrane; kidney development; limb morphogenesis; peptide binding; peptide biosynthetic process; peptide hormone processing; proteolysis; renin secretion into blood stream; respiratory tube development; secretory granule; serine-type endopeptidase activity; signal peptide processing IPR000742; IPR006212; IPR008979; IPR009030; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (Subtilisin/kexin-like protease PC5) (rPC5) Pcsk5 Rattus norvegicus (Rat) TR32441_c2_g2_i2 Q59149 PRCA_NOSS1 1.00E-16 GO:0005737; GO:0006508; GO:0004252 cytoplasm; proteolysis; serine-type endopeptidase activity IPR008979; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR002884; Calcium-dependent protease (EC 3.4.21.-) (Trypsin) prcA alr1381 Nostoc sp. (strain PCC 7120 / UTEX 2576) TR32442_c0_g1_i1 Q9W683 CP1A1_LIZSA 8.00E-13 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; IPR008066; Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) cyp1a1 Liza saliens (Leaping mullet) TR32442_c1_g2_i1 P12939 CP2DA_RAT 6.00E-19 GO:0070330; GO:0005789; GO:0020037; GO:0005506; GO:0004497 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity IPR001128; IPR017972; IPR002401; IPR008069; Cytochrome P450 2D10 (EC 1.14.14.1) (CYPIID10) (Cytochrome P450-CMF1B) (Cytochrome P450-DB5) (Debrisoquine 4-hydroxylase) Cyp2d10 Cyp2d-10 Cyp2d5 Rattus norvegicus (Rat) TR32442_c1_g2_i2 Q9VRM7 CP307_DROME 3.00E-08 GO:0007417; GO:0042335; GO:0007391; GO:0006697; GO:0048566; GO:0005783; GO:0005789; GO:0008258; GO:0020037; GO:0005506; GO:0007494; GO:0004497; GO:0048477; GO:0016705 "central nervous system development; cuticle development; dorsal closure; ecdysone biosynthetic process; embryonic digestive tract development; endoplasmic reticulum; endoplasmic reticulum membrane; head involution; heme binding; iron ion binding; midgut development; monooxygenase activity; oogenesis; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Cytochrome P450 307a1 (EC 1.14.-.-) (CYPCCCVIIA1) (Protein spook) spo Cyp307a1 CG10594 Drosophila melanogaster (Fruit fly) TR32442_c1_g2_i3 P00184 CP1A1_MOUSE 3.00E-44 GO:0042904; GO:0007568; GO:0009308; GO:0070330; GO:0043010; GO:0008283; GO:0009804; GO:0032451; GO:0048565; GO:0017144; GO:0009792; GO:0005789; GO:0016711; GO:0009812; GO:0020037; GO:0070365; GO:0046483; GO:0050665; GO:0017143; GO:0005506; GO:0060137; GO:0005739; GO:0016679; GO:0016712; GO:0006778; GO:0046677; GO:0046685; GO:0042493; GO:0032094; GO:0009635; GO:0055093; GO:0001666; GO:0010041; GO:0032496; GO:0009624; GO:0014070; GO:0009636; GO:0009615; GO:0033189; GO:0009611; GO:0008395; GO:0009404; GO:0070576 "9-cis-retinoic acid biosynthetic process; aging; amine metabolic process; aromatase activity; camera-type eye development; cell proliferation; coumarin metabolic process; demethylase activity; digestive tract development; drug metabolic process; embryo development ending in birth or egg hatching; endoplasmic reticulum membrane; flavonoid 3'-monooxygenase activity; flavonoid metabolic process; heme binding; hepatocyte differentiation; heterocycle metabolic process; hydrogen peroxide biosynthetic process; insecticide metabolic process; iron ion binding; maternal process involved in parturition; mitochondrion; oxidoreductase activity, acting on diphenols and related substances as donors; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; porphyrin-containing compound metabolic process; response to antibiotic; response to arsenic-containing substance; response to drug; response to food; response to herbicide; response to hyperoxia; response to hypoxia; response to iron(III) ion; response to lipopolysaccharide; response to nematode; response to organic cyclic compound; response to toxic substance; response to virus; response to vitamin A; response to wounding; steroid hydroxylase activity; toxin metabolic process; vitamin D 24-hydroxylase activity" IPR001128; IPR017972; IPR002401; IPR008066; Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (Cytochrome P450-P1) Cyp1a1 Cyp1a-1 Mus musculus (Mouse) TR32442_c1_g2_i4 B1NF19 C719D_ARGME 1.00E-07 GO:0047052; GO:0005789; GO:0020037; GO:0016021; GO:0005506; GO:0033075; GO:0004497 (S)-stylopine synthase activity; endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding; isoquinoline alkaloid biosynthetic process; monooxygenase activity IPR001128; IPR017972; IPR002401; (S)-stylopine synthase (STS) (EC 1.14.21.1) (Cytochrome P450 719A13) CYP719A13 Argemone mexicana (Mexican prickly poppy) TR32443_c0_g1_i2 Q921G8 GCP2_MOUSE 0 GO:0005737; GO:0005874; GO:0000226; GO:0005815; GO:0000922 cytoplasm; microtubule; microtubule cytoskeleton organization; microtubule organizing center; spindle pole IPR007259; Gamma-tubulin complex component 2 (GCP-2) Tubgcp2 Gcp2 Mus musculus (Mouse) TR32445_c0_g1_i1 Q0Q028 DFP3_ANTMY 2.00E-22 GO:0042742; GO:0042832; GO:0005576; GO:0045087 defense response to bacterium; defense response to protozoan; extracellular region; innate immune response IPR002861; Putative defense protein 3 (DFP-3) Antheraea mylitta (Tasar silkworm) TR32446_c0_g1_i3 Q8K1S7 KREM2_MOUSE 2.00E-06 GO:0016055; GO:0016021 Wnt receptor signaling pathway; integral to membrane IPR000859; IPR017076; IPR000001; IPR013806; IPR018056; IPR002889; Kremen protein 2 (Dickkopf receptor 2) (Kringle domain-containing transmembrane protein 2) (Kringle-containing protein marking the eye and the nose) Kremen2 Mus musculus (Mouse) TR32447_c1_g1_i1 Q19319 CADH4_CAEEL 3.00E-16 GO:0007411; GO:0005509; GO:0007163; GO:0007156; GO:0016021; GO:0005886 axon guidance; calcium ion binding; establishment or maintenance of cell polarity; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR013032; IPR001791; Cadherin-4 cdh-4 F25F2.2 Caenorhabditis elegans TR32447_c1_g1_i2 Q8BNA6 FAT3_MOUSE 9.00E-12 GO:0005509; GO:0007156; GO:0016021; GO:0007275; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; multicellular organismal development; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Protocadherin Fat 3 (FAT tumor suppressor homolog 3) Fat3 Gm1132 Gm510 Mus musculus (Mouse) TR32447_c2_g2_i1 Q9UGM3 DMBT1_HUMAN 2.00E-21 GO:0048306; GO:0051607; GO:0030855; GO:0005576; GO:0019898; GO:0043152; GO:0045087; GO:0001833; GO:0019048; GO:0030670; GO:0030858; GO:0015031; GO:0005578; GO:0005044; GO:0008329; GO:0035375; GO:0042589 calcium-dependent protein binding; defense response to virus; epithelial cell differentiation; extracellular region; extrinsic to membrane; induction of bacterial agglutination; innate immune response; inner cell mass cell proliferation; modulation by virus of host morphology or physiology; phagocytic vesicle membrane; positive regulation of epithelial cell differentiation; protein transport; proteinaceous extracellular matrix; scavenger receptor activity; signaling pattern recognition receptor activity; zymogen binding; zymogen granule membrane IPR000859; IPR001190; IPR017448; IPR001507; IPR017977; Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) TR32447_c2_g2_i2 Q5RDI1 PAMR1_PONAB 1.00E-05 GO:0003824; GO:0005576; GO:0008152 catalytic activity; extracellular region; metabolic process IPR000859; IPR000742; IPR013032; IPR001254; IPR001314; IPR000436; IPR009003; Inactive serine protease PAMR1 (Peptidase domain-containing protein associated with muscle regeneration 1) (Regeneration-associated muscle protease homolog) PAMR1 RAMP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR32447_c2_g2_i3 Q9WUB9 MARCO_MESAU 8.00E-28 GO:0005581; GO:0045087; GO:0016021; GO:0005044 collagen; innate immune response; integral to membrane; scavenger receptor activity IPR008160; IPR001190; IPR017448; Macrophage receptor MARCO (Macrophage receptor with collagenous structure) MARCO Mesocricetus auratus (Golden hamster) TR32447_c3_g1_i1 P10079 FBP1_STRPU 4.00E-54 GO:0032579; GO:0005509; GO:0016023; GO:0005615 apical lamina of hyaline layer; calcium ion binding; cytoplasmic membrane-bounded vesicle; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) TR32447_c3_g1_i3 Q14517 FAT1_HUMAN 2.00E-32 GO:0007015; GO:0009653; GO:0005509; GO:0016477; GO:0016337; GO:0005911; GO:0007267; GO:0007163; GO:0030175; GO:0007156; GO:0005887; GO:0030027; GO:0005634; GO:0048471 Q8N8S7; Q9NSC5; Q99JP6 actin filament organization; anatomical structure morphogenesis; calcium ion binding; cell migration; cell-cell adhesion; cell-cell junction; cell-cell signaling; establishment or maintenance of cell polarity; filopodium; homophilic cell adhesion; integral to plasma membrane; lamellipodium; nucleus; perinuclear region of cytoplasm IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) TR32447_c3_g2_i1 P49013 FBP3_STRPU 7.00E-35 GO:0005509; GO:0005615 calcium ion binding; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) TR32448_c1_g1_i1 O43301 HS12A_HUMAN 8.00E-102 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR32448_c1_g1_i3 A7I2D4 DNAK_CAMHC 7.00E-14 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK CHAB381_1119 Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A) TR32448_c1_g1_i5 C1DD88 DNAK_LARHH 6.00E-09 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK LHK_02739 Laribacter hongkongensis (strain HLHK9) TR32449_c1_g1_i1 Q9HCH3 CPNE5_HUMAN 4.00E-62 GO:0043005; GO:0043025 neuron projection; neuronal cell body IPR000008; IPR010734; IPR002035; Copine-5 (Copine V) CPNE5 KIAA1599 Homo sapiens (Human) TR32449_c2_g1_i1 Q86YQ8 CPNE8_HUMAN 2.00E-151 IPR000008; IPR010734; IPR002035; Copine-8 (Copine VIII) CPNE8 Homo sapiens (Human) TR32450_c1_g1_i1 A4II46 ABR_XENTR 8.00E-09 GO:0005096; GO:0005089; GO:0005622; GO:0035556; GO:0005543; GO:0043547; GO:0035023 GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; intracellular; intracellular signal transduction; phospholipid binding; positive regulation of GTPase activity; regulation of Rho protein signal transduction IPR000008; IPR000219; IPR001331; IPR011993; IPR001849; IPR008936; IPR000198; Active breakpoint cluster region-related protein abr Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR32450_c2_g1_i1 Q5RB40 HMHA1_PONAB 8.00E-29 GO:0005096; GO:0005622; GO:0035556; GO:0046872; GO:0043547 GTPase activator activity; intracellular; intracellular signal transduction; metal ion binding; positive regulation of GTPase activity IPR001060; IPR002219; IPR008936; IPR000198; Minor histocompatibility protein HA-1 HMHA1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR32450_c5_g1_i1 Q5ZMM3 RHG15_CHICK 8.00E-12 GO:0030675; GO:0005737; GO:0016020; GO:0005543; GO:0008360; GO:0007165 Rac GTPase activator activity; cytoplasm; membrane; phospholipid binding; regulation of cell shape; signal transduction IPR011993; IPR001849; IPR015767; IPR008936; IPR000198; Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) ARHGAP15 RCJMB04_1j23 Gallus gallus (Chicken) TR32450_c5_g1_i2 Q5ZMW5 RHG26_CHICK 3.00E-10 GO:0005096; GO:0005737; GO:0005856; GO:0046847; GO:0005925; GO:0005543; GO:0043547; GO:0007165 GTPase activator activity; cytoplasm; cytoskeleton; filopodium assembly; focal adhesion; phospholipid binding; positive regulation of GTPase activity; signal transduction IPR013606; IPR011993; IPR001849; IPR008936; IPR000198; IPR001452; Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (Rho-type GTPase-activating protein 26) ARHGAP26 GRAF Gallus gallus (Chicken) TR32453_c1_g1_i1 P21328 RTJK_DROME 2.00E-09 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) TR32454_c3_g1_i1 P19477 FIBA_PARPA 9.00E-49 IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein A (FREP-A) Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) TR32454_c3_g1_i2 Q15485 FCN2_HUMAN 1.00E-22 GO:0003823; GO:0005509; GO:0030246; GO:0005581; GO:0001867; GO:0005576; GO:0008228 Q07954 "antigen binding; calcium ion binding; carbohydrate binding; collagen; complement activation, lectin pathway; extracellular region; opsonization" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-2 (37 kDa elastin-binding protein) (Collagen/fibrinogen domain-containing protein 2) (EBP-37) (Ficolin-B) (Ficolin-beta) (Hucolin) (L-ficolin) (Serum lectin p35) FCN2 FCNL Homo sapiens (Human) TR32454_c3_g1_i3 P19477 FIBA_PARPA 2.00E-35 IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein A (FREP-A) Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) TR32457_c0_g1_i1 Q6TXF1 ARRD3_RAT 3.00E-10 GO:0005737 cytoplasm IPR011021; IPR011022; IPR014756; Arrestin domain-containing protein 3 (Liver regeneration-related protein LRRG00048) Arrdc3 Rattus norvegicus (Rat) TR32460_c0_g1_i1 Q5W5X9 TTC23_HUMAN 6.00E-15 IPR011990; IPR013105; Tetratricopeptide repeat protein 23 (TPR repeat protein 23) (Cervical cancer proto-oncogene 8 protein) (HCC-8) TTC23 HCC8 Homo sapiens (Human) TR32461_c0_g1_i1 Q0P4P2 FBCD1_XENTR 1.00E-69 GO:0008061; GO:0016021; GO:0046872 chitin binding; integral to membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 fibcd1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR32461_c0_g1_i2 Q29116 TENA_PIG 5.00E-70 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (P230) (Tenascin-C) (TN-C) TNC HXB Sus scrofa (Pig) TR32461_c0_g1_i3 E2IYB3 FCNV1_VARKO 8.00E-29 GO:0005576 extracellular region IPR008160; IPR014716; IPR002181; Veficolin-1 (Fragment) Varanus komodoensis (Komodo dragon) TR32464_c0_g1_i1 P18653 KS6A1_MOUSE 0 GO:0005524; GO:0005737; GO:0007243; GO:0000287; GO:0043066; GO:0005634; GO:2000491; GO:0004674; GO:0005819 ATP binding; cytoplasm; intracellular protein kinase cascade; magnesium ion binding; negative regulation of apoptotic process; nucleus; positive regulation of hepatic stellate cell activation; protein serine/threonine kinase activity; spindle IPR000961; IPR011009; IPR017892; IPR000719; IPR017441; IPR016239; IPR002290; IPR008271; Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) Rps6ka1 Mapkapk1a Rsk1 Mus musculus (Mouse) TR32464_c0_g1_i2 Q21734 KS6A1_CAEEL 2.00E-151 GO:0005524; GO:0007243; GO:0000287; GO:0004674 ATP binding; intracellular protein kinase cascade; magnesium ion binding; protein serine/threonine kinase activity IPR000961; IPR011009; IPR017892; IPR000719; IPR017441; IPR016239; IPR002290; IPR008271; Putative ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) rskn-1 T01H8.1 Caenorhabditis elegans TR32466_c0_g2_i1 A5D8S0 KIZ_DANRE 1.00E-18 GO:0005813; GO:0005737; GO:0007051 centrosome; cytoplasm; spindle organization IPR026742; Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) plk1s1 kiz zgc:162576 Danio rerio (Zebrafish) (Brachydanio rerio) TR32466_c1_g2_i1 Q2M2Z5 KIZ_HUMAN 9.00E-09 GO:0005813; GO:0005737; GO:0007051 Q9P209 centrosome; cytoplasm; spindle organization IPR026742; Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) PLK1S1 C20orf19 KIZ NCRNA00153 HT013 Homo sapiens (Human) TR32467_c0_g1_i1 Q6GNT9 MEMO1_XENLA 1.00E-143 IPR002737; Protein MEMO1 (Mediator of ErbB2-driven cell motility 1) (Memo-1) memo1 Xenopus laevis (African clawed frog) TR3247_c0_g1_i1 Q15051 IQCB1_HUMAN 2.00E-13 GO:0005516; GO:0005813; GO:0042384; GO:0005737; GO:0048496; GO:0045494; GO:0032391; GO:0001750 calmodulin binding; centrosome; cilium assembly; cytoplasm; maintenance of organ identity; photoreceptor cell maintenance; photoreceptor connecting cilium; photoreceptor outer segment IPR016024; IPR000048; IPR027417; IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5) (p53 and DNA damage-regulated IQ motif protein) (PIQ) IQCB1 KIAA0036 NPHP5 OK/SW-cl.85 Homo sapiens (Human) TR32472_c0_g1_i2 Q28I29 DTWD1_XENTR 5.00E-58 IPR005636; DTW domain-containing protein 1 dtwd1 TEgg073n17.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR32472_c0_g1_i3 Q9D8U7 DTWD1_MOUSE 2.00E-53 IPR005636; DTW domain-containing protein 1 Dtwd1 Mus musculus (Mouse) TR32476_c0_g1_i1 A8KBL7 MEL2A_DANRE 5.00E-133 GO:0016427 tRNA (cytosine) methyltransferase activity IPR026113; Methyltransferase-like protein 2-A (EC 2.1.1.-) mettl2a mettl2 zgc:110598 Danio rerio (Zebrafish) (Brachydanio rerio) TR32476_c0_g1_i2 A8KBL7 MEL2A_DANRE 5.00E-143 GO:0016427 tRNA (cytosine) methyltransferase activity IPR026113; Methyltransferase-like protein 2-A (EC 2.1.1.-) mettl2a mettl2 zgc:110598 Danio rerio (Zebrafish) (Brachydanio rerio) TR32480_c0_g1_i1 Q9PTG8 TACC3_XENLA 2.00E-26 GO:0005737; GO:0017148; GO:0043234 Q91572 cytoplasm; negative regulation of translation; protein complex IPR007707; Transforming acidic coiled-coil-containing protein 3 (Cytoplasmic polyadenylation element-binding protein-associated factor Maskin) (CPEB-associated factor Maskin) tacc3 maskin Xenopus laevis (African clawed frog) TR32481_c8_g7_i1 Q16TM5 BND7A_AEDAE 4.00E-09 GO:0016021 integral to membrane IPR001107; IPR018080; IPR001972; Band 7 protein AAEL010189 AAEL010189 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR32482_c0_g1_i1 P78312 F193A_HUMAN 2.00E-50 GO:0005737; GO:0005886 cytoplasm; plasma membrane Protein FAM193A (Protein IT14) FAM193A C4orf8 RES4-22 Homo sapiens (Human) TR32483_c1_g1_i1 Q6AXQ0 SAE1_RAT 1.00E-14 GO:0019948; GO:0016874; GO:0005634; GO:0008022; GO:0016925 SUMO activating enzyme activity; ligase activity; nucleus; protein C-terminus binding; protein sumoylation IPR009036; IPR016040; IPR000594; IPR000011; Protein modification; protein sumoylation. "SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed]" Sae1 Uble1a Rattus norvegicus (Rat) TR32483_c4_g1_i1 Q8C7R4 UBA6_MOUSE 0 GO:0005524; GO:0019780; GO:0005737; GO:0016874; GO:0016567; GO:0006511 ATP binding; FAT10 activating enzyme activity; cytoplasm; ligase activity; protein ubiquitination; ubiquitin-dependent protein catabolic process IPR009036; IPR016040; IPR000594; IPR018965; IPR023280; IPR000127; IPR019572; IPR018075; IPR000011; Protein modification; protein ubiquitination. Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) Uba6 Ube1l2 Mus musculus (Mouse) TR32483_c4_g1_i2 Q8C7R4 UBA6_MOUSE 3.00E-61 GO:0005524; GO:0019780; GO:0005737; GO:0016874; GO:0016567; GO:0006511 ATP binding; FAT10 activating enzyme activity; cytoplasm; ligase activity; protein ubiquitination; ubiquitin-dependent protein catabolic process IPR009036; IPR016040; IPR000594; IPR018965; IPR023280; IPR000127; IPR019572; IPR018075; IPR000011; Protein modification; protein ubiquitination. Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) Uba6 Ube1l2 Mus musculus (Mouse) TR32486_c0_g1_i1 Q76HM9 HYAL3_RAT 9.00E-69 GO:0005975; GO:0051216; GO:0071493; GO:0071347; GO:0071356; GO:0031410; GO:0005576; GO:0030214; GO:0033906; GO:0004415; GO:0006954; GO:0005764; GO:0046677; GO:0009615 carbohydrate metabolic process; cartilage development; cellular response to UV-B; cellular response to interleukin-1; cellular response to tumor necrosis factor; cytoplasmic vesicle; extracellular region; hyaluronan catabolic process; hyaluronoglucuronidase activity; hyalurononglucosaminidase activity; inflammatory response; lysosome; response to antibiotic; response to virus IPR013785; IPR000742; IPR013032; IPR017853; IPR018155; IPR027260; Hyaluronidase-3 (Hyal-3) (EC 3.2.1.35) (Hyaluronoglucosaminidase-3) Hyal3 Rattus norvegicus (Rat) TR32487_c0_g1_i1 A0MGZ7 H6ST3_DANRE 4.00E-103 GO:0016021; GO:0008146 integral to membrane; sulfotransferase activity IPR010635; IPR027417; IPR005331; Heparan-sulfate 6-O-sulfotransferase 3 (HS 6-OST-3) (EC 2.8.2.-) hs6st3 Danio rerio (Zebrafish) (Brachydanio rerio) TR32489_c0_g1_i1 P32254 RASS_DICDI 3.00E-30 GO:0005525; GO:0003924; GO:0007265; GO:0007015; GO:0000902; GO:0006928; GO:0030866; GO:0005622; GO:0051271; GO:0006907; GO:0005886; GO:0050766; GO:0042127; GO:0019953 GTP binding; GTPase activity; Ras protein signal transduction; actin filament organization; cell morphogenesis; cellular component movement; cortical actin cytoskeleton organization; intracellular; negative regulation of cellular component movement; pinocytosis; plasma membrane; positive regulation of phagocytosis; regulation of cell proliferation; sexual reproduction IPR027417; IPR005225; IPR001806; IPR020849; Ras-like protein rasS rasS DDB_G0283537 Dictyostelium discoideum (Slime mold) TR32489_c0_g1_i2 Q75J93 CPAS1_DICDI 2.00E-18 GO:0030127; GO:0006888; GO:0005525; GO:0003924; GO:0006886; GO:0007264; GO:0008270 COPII vesicle coat; ER to Golgi vesicle-mediated transport; GTP binding; GTPase activity; intracellular protein transport; small GTPase mediated signal transduction; zinc ion binding IPR027417; IPR005225; IPR001806; IPR020849; IPR002035; IPR006895; Circularly permutated Ras protein 1 (DdiCPRas1) cpras1 DDB_G0277381 Dictyostelium discoideum (Slime mold) TR32489_c0_g1_i3 Q0VCJ7 RERG_BOVIN 2.00E-42 GO:0005525; GO:0003924; GO:0005829; GO:0016020; GO:0030308; GO:0008285; GO:0005634; GO:0009725; GO:0007264 GTP binding; GTPase activity; cytosol; membrane; negative regulation of cell growth; negative regulation of cell proliferation; nucleus; response to hormone stimulus; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; Ras-related and estrogen-regulated growth inhibitor RERG Bos taurus (Bovine) TR32490_c0_g1_i1 E9Q956 MCMD2_MOUSE 6.00E-77 GO:0005524; GO:0003677; GO:0006260 ATP binding; DNA binding; DNA replication IPR001208; MCM domain-containing protein 2 Mcmdc2 Mus musculus (Mouse) TR32490_c0_g1_i2 E9Q956 MCMD2_MOUSE 4.00E-77 GO:0005524; GO:0003677; GO:0006260 ATP binding; DNA binding; DNA replication IPR001208; MCM domain-containing protein 2 Mcmdc2 Mus musculus (Mouse) TR32490_c0_g1_i4 F1N2W9 MCM9_BOVIN 5.00E-12 GO:0005524; GO:0003677; GO:0097362; GO:0000724; GO:0007292; GO:0004386; GO:0005634 ATP binding; DNA binding; MCM8-MCM9 complex; double-strand break repair via homologous recombination; female gamete generation; helicase activity; nucleus IPR003593; IPR001208; IPR012340; IPR027417; DNA helicase MCM9 (EC 3.6.4.12) (Minichromosome maintenance 9) MCM9 Bos taurus (Bovine) TR32490_c0_g1_i5 Q9UXG1 MCM_SULSO 3.00E-17 GO:0005524; GO:0003677; GO:0006260; GO:0004386 Q9UXG0 ATP binding; DNA binding; DNA replication; helicase activity IPR003593; IPR001208; IPR027925; IPR012340; IPR027417; Minichromosome maintenance protein MCM (EC 3.6.4.12) MCM SSO0774 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) TR32490_c0_g1_i9 E9Q956 MCMD2_MOUSE 7.00E-77 GO:0005524; GO:0003677; GO:0006260 ATP binding; DNA binding; DNA replication IPR001208; MCM domain-containing protein 2 Mcmdc2 Mus musculus (Mouse) TR32491_c0_g1_i2 Q8NE09 RGS22_HUMAN 1.00E-07 GO:0005096; GO:0005737; GO:0005886; GO:0038032 GTPase activator activity; cytoplasm; plasma membrane; termination of G-protein coupled receptor signaling pathway IPR016137; IPR000342; Regulator of G-protein signaling 22 (RGS22) RGS22 Homo sapiens (Human) TR32495_c6_g1_i1 Q5I598 MTHR_BOVIN 0 GO:0006555; GO:0004489; GO:0035999 methionine metabolic process; methylenetetrahydrofolate reductase (NAD(P)H) activity; tetrahydrofolate interconversion IPR004621; IPR003171; One-carbon metabolism; tetrahydrofolate interconversion. Methylenetetrahydrofolate reductase (EC 1.5.1.20) MTHFR Bos taurus (Bovine) TR32497_c2_g1_i1 Q9Y4G6 TLN2_HUMAN 2.00E-29 GO:0003779; GO:0015629; GO:0007155; GO:0005911; GO:0007043; GO:0005737; GO:0007016; GO:0005916; GO:0005925; GO:0005886; GO:0001726; GO:0005200; GO:0005198; GO:0045202 P00519; P05107 actin binding; actin cytoskeleton; cell adhesion; cell-cell junction; cell-cell junction assembly; cytoplasm; cytoskeletal anchoring at plasma membrane; fascia adherens; focal adhesion; plasma membrane; ruffle; structural constituent of cytoskeleton; structural molecule activity; synapse IPR019749; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR002558; IPR002404; IPR011993; IPR015711; IPR015224; IPR015009; IPR006077; Talin-2 TLN2 KIAA0320 Homo sapiens (Human) TR32499_c0_g1_i1 Q05B56 TF2H3_BOVIN 1.00E-106 GO:0008094; GO:0008353; GO:0000439; GO:0005675; GO:0046872; GO:0006289; GO:0006355; GO:0006366 "DNA-dependent ATPase activity; RNA polymerase II carboxy-terminal domain kinase activity; core TFIIH complex; holo TFIIH complex; metal ion binding; nucleotide-excision repair; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter" IPR004600; General transcription factor IIH subunit 3 (General transcription factor IIH polypeptide 3) GTF2H3 Bos taurus (Bovine) TR32500_c1_g1_i1 Q8BZ10 TM11G_MOUSE 1.00E-14 GO:0005576; GO:0005887; GO:0006508; GO:0004252 extracellular region; integral to plasma membrane; proteolysis; serine-type endopeptidase activity IPR017329; IPR001254; IPR018114; IPR001314; IPR000082; IPR009003; Transmembrane protease serine 11G (EC 3.4.21.-) (Serine protease DESC4) [Cleaved into: Transmembrane protease serine 11G non-catalytic chain; Transmembrane protease serine 11G catalytic chain] Tmprss11g Desc4 Mus musculus (Mouse) TR32500_c3_g2_i2 Q5VYJ5 CJ112_HUMAN 1.00E-14 GO:0016021 integral to membrane IPR008985; IPR023415; IPR002172; IPR000998; MAM and LDL-receptor class A domain-containing protein C10orf112 C10orf112 Homo sapiens (Human) TR32501_c0_g1_i1 Q95NQ0 MTH2_DROSI 2.00E-18 GO:0004930; GO:0016021; GO:0005886; GO:0006950 G-protein coupled receptor activity; integral to membrane; plasma membrane; response to stress IPR017981; IPR000832; IPR023311; IPR010596; G-protein coupled receptor Mth2 (Protein methuselah-2) mth2 Drosophila simulans (Fruit fly) TR32501_c0_g1_i2 Q9V818 MTH3_DROME 4.00E-10 GO:0004930; GO:0008340; GO:0016021; GO:0005886; GO:0042594 Q27415-1 G-protein coupled receptor activity; determination of adult lifespan; integral to membrane; plasma membrane; response to starvation IPR017981; IPR000832; IPR023311; IPR010596; Probable G-protein coupled receptor Mth-like 3 (Protein methuselah-like 3) mthl3 BEST:GM02553 CG6530 Drosophila melanogaster (Fruit fly) TR32501_c0_g1_i3 Q9VXD9 MTH1_DROME 1.00E-16 GO:0004930; GO:0008340; GO:0016021; GO:0005886; GO:0042594 G-protein coupled receptor activity; determination of adult lifespan; integral to membrane; plasma membrane; response to starvation IPR017981; IPR000832; IPR023311; Probable G-protein coupled receptor Mth-like 1 (Protein methuselah-like 1) mthl1 CG4521 Drosophila melanogaster (Fruit fly) TR32501_c0_g1_i4 Q95NT6 MTH2_DROYA 1.00E-17 GO:0004930; GO:0016021; GO:0005886; GO:0006950 G-protein coupled receptor activity; integral to membrane; plasma membrane; response to stress IPR017981; IPR000832; IPR023311; IPR010596; G-protein coupled receptor Mth2 (Protein methuselah-2) mth2 Drosophila yakuba (Fruit fly) TR32501_c0_g1_i5 Q95NQ0 MTH2_DROSI 2.00E-18 GO:0004930; GO:0016021; GO:0005886; GO:0006950 G-protein coupled receptor activity; integral to membrane; plasma membrane; response to stress IPR017981; IPR000832; IPR023311; IPR010596; G-protein coupled receptor Mth2 (Protein methuselah-2) mth2 Drosophila simulans (Fruit fly) TR32503_c1_g1_i1 Q5PRC1 LHFP_DANRE 7.00E-51 GO:0016021 integral to membrane IPR019372; Lipoma HMGIC fusion partner homolog lhfp zgc:101683 Danio rerio (Zebrafish) (Brachydanio rerio) TR32504_c1_g1_i1 Q49AA0 ZN642_HUMAN 8.00E-58 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein ZFP69 (Zinc finger protein 642) ZFP69 ZNF642 Homo sapiens (Human) TR32505_c3_g1_i1 P19526 FUT1_HUMAN 1.00E-25 GO:0005794; GO:0032580; GO:0042355; GO:0008107; GO:0005887; GO:0006486 Golgi apparatus; Golgi cisterna membrane; L-fucose catabolic process; galactoside 2-alpha-L-fucosyltransferase activity; integral to plasma membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha(1,2)FT 1) (Blood group H alpha 2-fucosyltransferase) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" FUT1 H HSC Homo sapiens (Human) TR32506_c1_g1_i1 B5DGI7 RBM8A_SALSA 3.00E-54 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0051028; GO:0016607; GO:0000184; GO:0000166; GO:0000381; GO:0006417 "RNA binding; RNA splicing; cytoplasm; mRNA processing; mRNA transport; nuclear speck; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleotide binding; regulation of alternative mRNA splicing, via spliceosome; regulation of translation" IPR012677; IPR008111; IPR000504; RNA-binding protein 8A (RNA-binding motif protein 8A) (Ribonucleoprotein RBM8A) rbm8a rbm8 Salmo salar (Atlantic salmon) TR32507_c6_g2_i1 Q9UHG3 PCYOX_HUMAN 2.00E-100 GO:0008555; GO:0005764; GO:0005886; GO:0030327; GO:0030328; GO:0030329; GO:0001735; GO:0034361 chloride-transporting ATPase activity; lysosome; plasma membrane; prenylated protein catabolic process; prenylcysteine catabolic process; prenylcysteine metabolic process; prenylcysteine oxidase activity; very-low-density lipoprotein particle IPR010795; IPR017046; Prenylcysteine oxidase 1 (EC 1.8.3.5) (Prenylcysteine lyase) PCYOX1 KIAA0908 PCL1 UNQ597/PRO1183 Homo sapiens (Human) TR32508_c0_g1_i1 D1BD84 MSHA_SANKS 1.00E-10 GO:0008375; GO:0000287; GO:0010125 acetylglucosaminyltransferase activity; magnesium ion binding; mycothiol biosynthetic process IPR001296; IPR017814; D-inositol 3-phosphate glycosyltransferase (EC 2.4.1.250) (N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase) (GlcNAc-Ins-P N-acetylglucosaminyltransferase) mshA Sked_31920 Sanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74) TR32508_c0_g1_i2 Q9H553 ALG2_HUMAN 3.00E-102 GO:0004378; GO:0000033; GO:0048306; GO:0006488; GO:0005789; GO:0033164; GO:0016021; GO:0005634; GO:0048471; GO:0043687; GO:0018279; GO:0043495; GO:0033577; GO:0051592 "GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity; alpha-1,3-mannosyltransferase activity; calcium-dependent protein binding; dolichol-linked oligosaccharide biosynthetic process; endoplasmic reticulum membrane; glycolipid 6-alpha-mannosyltransferase activity; integral to membrane; nucleus; perinuclear region of cytoplasm; post-translational protein modification; protein N-linked glycosylation via asparagine; protein anchor; protein glycosylation in endoplasmic reticulum; response to calcium ion" IPR027054; IPR001296; Protein modification; protein glycosylation. "Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132) (EC 2.4.1.257) (Asparagine-linked glycosylation protein 2 homolog) (GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase) (GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase) (GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase)" ALG2 UNQ666/PRO1298 Homo sapiens (Human) TR32508_c0_g2_i1 O94738 ALG2_RHIPU 1.00E-55 GO:0004378; GO:0033164; GO:0016021; GO:0006486 "GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity; glycolipid 6-alpha-mannosyltransferase activity; integral to membrane; protein glycosylation" IPR027054; IPR001296; Protein modification; protein glycosylation. "Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132) (EC 2.4.1.257) (GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase) (GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase) (GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase)" ALG2 Rhizomucor pusillus TR32509_c0_g1_i1 P33299 PRS7_YEAST 0 GO:0005524; GO:0016887; GO:0005737; GO:0005634; GO:0045899; GO:0045732; GO:0070682; GO:0008540; GO:0006511 P48510; P38348; P22141; P32628; P38764; P40327; P33298; P53549; P33297; Q01939; P19812 "ATP binding; ATPase activity; cytoplasm; nucleus; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; positive regulation of protein catabolic process; proteasome regulatory particle assembly; proteasome regulatory particle, base subcomplex; ubiquitin-dependent protein catabolic process" IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 7 homolog (Protein CIM5) (Tat-binding homolog 3) RPT1 CIM5 YTA3 YKL145W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR32509_c0_g1_i2 O28972 Y1297_ARCFU 7.00E-65 GO:0005524; GO:0017111 ATP binding; nucleoside-triphosphatase activity IPR003593; IPR005938; IPR009010; IPR003959; IPR003960; IPR004201; IPR003338; IPR027417; IPR015415; Cell division cycle protein 48 homolog AF_1297 AF_1297 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) TR32509_c0_g1_i3 Q4R4R0 PRS7_MACFA 0 GO:0005524; GO:0016887; GO:0000932; GO:0005634; GO:0022624; GO:0006511 ATP binding; ATPase activity; cytoplasmic mRNA processing body; nucleus; proteasome accessory complex; ubiquitin-dependent protein catabolic process IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) PSMC2 QnpA-16482 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR32509_c0_g1_i4 O75351 VPS4B_HUMAN 3.00E-30 GO:0005524; GO:0042623; GO:0007049; GO:0051301; GO:0005829; GO:0005769; GO:0010008; GO:0007032; GO:0032510; GO:0032367; GO:0005770; GO:0031902; GO:0005764; GO:0005634; GO:0006813; GO:0015031; GO:0033993; GO:0005774; GO:0016032 "ATP binding; ATPase activity, coupled; cell cycle; cell division; cytosol; early endosome; endosome membrane; endosome organization; endosome to lysosome transport via multivesicular body sorting pathway; intracellular cholesterol transport; late endosome; late endosome membrane; lysosome; nucleus; potassium ion transport; protein transport; response to lipid; vacuolar membrane; viral process" IPR003593; IPR003959; IPR003960; IPR007330; IPR027417; IPR015415; Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1) VPS4B SKD1 VPS42 MIG1 Homo sapiens (Human) TR32509_c0_g1_i5 Q41365 PRS7_SPIOL 0 GO:0005524; GO:0005737; GO:0017111; GO:0005634; GO:0000502; GO:0030163 ATP binding; cytoplasm; nucleoside-triphosphatase activity; nucleus; proteasome complex; protein catabolic process IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (26S proteasome subunit 7) (Regulatory particle triple-A ATPase subunit 1) RPT1 Spinacia oleracea (Spinach) TR32511_c1_g1_i1 Q49538 VLPF_MYCHR 6.00E-09 GO:0005886 plasma membrane Variant surface antigen F (VlpF prolipoprotein) vlpF Mycoplasma hyorhinis TR32511_c3_g1_i1 P37198 NUP62_HUMAN 2.00E-84 GO:0042169; GO:0005975; GO:0007569; GO:0008219; GO:0003682; GO:0019221; GO:0005737; GO:0015758; GO:0009755; GO:0051028; GO:0007077; GO:0043407; GO:0046580; GO:0043066; GO:0008285; GO:0042059; GO:0031965; GO:0005643; GO:0031074; GO:0006913; GO:0043123; GO:0045742; GO:0045893; GO:0015031; GO:0030159; GO:0046578; GO:0010827; GO:0030529; GO:0044281; GO:0000922; GO:0017056; GO:0046966; GO:0006351; GO:0055085; GO:0043130; GO:0016032 O15265; Q9UBU9 "SH2 domain binding; carbohydrate metabolic process; cell aging; cell death; chromatin binding; cytokine-mediated signaling pathway; cytoplasm; glucose transport; hormone-mediated signaling pathway; mRNA transport; mitotic nuclear envelope disassembly; negative regulation of MAP kinase activity; negative regulation of Ras protein signal transduction; negative regulation of apoptotic process; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; nuclear membrane; nuclear pore; nucleocytoplasmic shuttling complex; nucleocytoplasmic transport; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; protein transport; receptor signaling complex scaffold activity; regulation of Ras protein signal transduction; regulation of glucose transport; ribonucleoprotein complex; small molecule metabolic process; spindle pole; structural constituent of nuclear pore; thyroid hormone receptor binding; transcription, DNA-dependent; transmembrane transport; ubiquitin binding; viral process" IPR026010; IPR007758; Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) NUP62 Homo sapiens (Human) TR32513_c0_g1_i1 Q6PFS7 ATG3_DANRE 2.00E-28 GO:0019777; GO:0019776; GO:0000045; GO:0005737; GO:0043653; GO:0015031 Atg12 ligase activity; Atg8 ligase activity; autophagic vacuole assembly; cytoplasm; mitochondrial fragmentation involved in apoptotic process; protein transport IPR007135; IPR019461; IPR007134; Ubiquitin-like-conjugating enzyme ATG3 (EC 6.3.2.-) (Autophagy-related protein 3) (APG3-like) atg3 apg3l zgc:64156 Danio rerio (Zebrafish) (Brachydanio rerio) TR32513_c0_g2_i1 Q6PFS7 ATG3_DANRE 4.00E-129 GO:0019777; GO:0019776; GO:0000045; GO:0005737; GO:0043653; GO:0015031 Atg12 ligase activity; Atg8 ligase activity; autophagic vacuole assembly; cytoplasm; mitochondrial fragmentation involved in apoptotic process; protein transport IPR007135; IPR019461; IPR007134; Ubiquitin-like-conjugating enzyme ATG3 (EC 6.3.2.-) (Autophagy-related protein 3) (APG3-like) atg3 apg3l zgc:64156 Danio rerio (Zebrafish) (Brachydanio rerio) TR32515_c1_g1_i2 P81614 MYMY_MYTED 2.00E-09 GO:0042742; GO:0050832; GO:0005576; GO:0031640 defense response to bacterium; defense response to fungus; extracellular region; killing of cells of other organism Mytimycin (Fragment) Mytilus edulis (Blue mussel) TR32516_c0_g1_i1 P04352 CALM_CHLRE 4.00E-13 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Chlamydomonas reinhardtii (Chlamydomonas smithii) TR32516_c0_g1_i2 Q9C6P3 CDPKX_ARATH 3.00E-12 GO:0005524; GO:0005509; GO:0005886; GO:0004674 ATP binding; calcium ion binding; plasma membrane; protein serine/threonine kinase activity IPR011992; IPR018247; IPR002048; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium-dependent protein kinase 33 (EC 2.7.11.1) CPK33 At1g50700 F17J6.22 Arabidopsis thaliana (Mouse-ear cress) TR32517_c2_g2_i1 Q9UTA8 YL8A_SCHPO 6.00E-36 GO:0044262; GO:0005829; GO:0005634; GO:0046547 cellular carbohydrate metabolic process; cytosol; nucleus; trans-aconitate 3-methyltransferase activity IPR013216; Uncharacterized methyltransferase-like C25B8.10 (EC 2.1.1.-) SPAC25B8.10 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR32518_c0_g1_i4 H2A0L0 TYRO1_PINMG 5.00E-41 GO:0005576; GO:0046872; GO:0016491 extracellular region; metal ion binding; oxidoreductase activity IPR002227; IPR008922; Tyrosinase-like protein 1 (EC 1.14.18.-) (Tyrosinase 1) Pinctada margaritifera (Black-lipped pearl oyster) TR32518_c0_g1_i5 H2A0L0 TYRO1_PINMG 5.00E-41 GO:0005576; GO:0046872; GO:0016491 extracellular region; metal ion binding; oxidoreductase activity IPR002227; IPR008922; Tyrosinase-like protein 1 (EC 1.14.18.-) (Tyrosinase 1) Pinctada margaritifera (Black-lipped pearl oyster) TR32519_c0_g1_i1 Q6NUQ1 RINT1_HUMAN 7.00E-150 GO:0031572; GO:0005783; GO:0005789; GO:0015031; GO:0016192 G2 DNA damage checkpoint; endoplasmic reticulum; endoplasmic reticulum membrane; protein transport; vesicle-mediated transport IPR007528; RAD50-interacting protein 1 (RAD50 interactor 1) (HsRINT-1) (RINT-1) RINT1 Homo sapiens (Human) TR32520_c0_g1_i2 Q767K8 RT18B_PIG 2.00E-27 GO:0005739; GO:0005840; GO:0003735; GO:0006412 mitochondrion; ribosome; structural constituent of ribosome; translation IPR001648; "28S ribosomal protein S18b, mitochondrial (MRP-S18-b) (Mrps18-b) (S18mt-b) (28S ribosomal protein S18-2, mitochondrial) (MRP-S18-2)" MRPS18B Sus scrofa (Pig) TR32522_c1_g1_i2 O08755 HNF6_MOUSE 7.00E-88 GO:0030183; GO:0003677; GO:0045165; GO:0042384; GO:0031018; GO:0007492; GO:0002064; GO:0006006; GO:0001889; GO:0030512; GO:0005654; GO:0030335; GO:0045944; GO:0001952; GO:0043565; GO:0003700; GO:0048536; GO:0006351 "B cell differentiation; DNA binding; cell fate commitment; cilium assembly; endocrine pancreas development; endoderm development; epithelial cell development; glucose metabolic process; liver development; negative regulation of transforming growth factor beta receptor signaling pathway; nucleoplasm; positive regulation of cell migration; positive regulation of transcription from RNA polymerase II promoter; regulation of cell-matrix adhesion; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; spleen development; transcription, DNA-dependent" IPR003350; IPR001356; IPR009057; IPR010982; Hepatocyte nuclear factor 6 (HNF-6) (One cut domain family member 1) (One cut homeobox 1) Onecut1 Hnf6 Hnf6a Mus musculus (Mouse) TR32523_c3_g4_i2 Q52KJ8 MSRB1_RAT 1.00E-36 GO:0003779; GO:0030041; GO:0005737; GO:0005856; GO:0045087; GO:0046872; GO:0005634; GO:0033743 actin binding; actin filament polymerization; cytoplasm; cytoskeleton; innate immune response; metal ion binding; nucleus; peptide-methionine (R)-S-oxide reductase activity IPR002579; IPR011057; Methionine-R-sulfoxide reductase B1 (MsrB1) (EC 1.8.4.-) (Selenoprotein X) (SelX) Msrb1 Sepx1 Rattus norvegicus (Rat) TR32525_c0_g1_i1 P35402 ERD2_ARATH 4.00E-40 GO:0005794; GO:0005046; GO:0005801; GO:0005783; GO:0005789; GO:0016021; GO:0006621; GO:0015031; GO:0016192 Golgi apparatus; KDEL sequence binding; cis-Golgi network; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; protein retention in ER lumen; protein transport; vesicle-mediated transport IPR000133; ER lumen protein retaining receptor (HDEL receptor) ERD2 At1g29330 F15D2.26 F28N24.1 Arabidopsis thaliana (Mouse-ear cress) TR32525_c0_g1_i3 Q6PEH1 ERD22_DANRE 5.00E-68 GO:0046923; GO:0005789; GO:0016021; GO:0006621; GO:0015031; GO:0016192 ER retention sequence binding; endoplasmic reticulum membrane; integral to membrane; protein retention in ER lumen; protein transport; vesicle-mediated transport IPR000133; ER lumen protein retaining receptor 2 (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2) kdelr2 Danio rerio (Zebrafish) (Brachydanio rerio) TR32526_c0_g1_i1 A4QNP7 DMTA2_XENTR 5.00E-28 GO:0046872; GO:0005634; GO:0043565; GO:0003700 metal ion binding; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR001275; IPR005173; IPR026607; IPR009060; Doublesex- and mab-3-related transcription factor A2 (Doublesex- and mab-3-related transcription factor 5) dmrta2 dmrt5 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR32527_c2_g1_i1 P35816 PDP1_BOVIN 2.00E-80 GO:0004741; GO:0005509; GO:0016311; GO:0000287; GO:0005759; GO:0005739; GO:0006470; GO:0004722 [pyruvate dehydrogenase (lipoamide)] phosphatase activity; calcium ion binding; dephosphorylation; magnesium ion binding; mitochondrial matrix; mitochondrion; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP 1) (EC 3.1.3.43) (Protein phosphatase 2C) (Pyruvate dehydrogenase phosphatase catalytic subunit 1) (PDPC 1)" PDP1 PDP PPM2C Bos taurus (Bovine) TR32528_c1_g2_i1 A8E4S7 MB213_DANRE 7.00E-37 IPR024810; Protein mab-21-like 3 mab21L3 si:ch211-246m4.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR32528_c1_g2_i5 Q6GNM3 MB213_XENLA 2.00E-20 IPR024810; IPR024802; Protein mab-21-like 3 mab21L3 Xenopus laevis (African clawed frog) TR32528_c1_g2_i6 Q8CI17 MB213_MOUSE 1.00E-32 IPR024810; IPR024802; Protein mab-21-like 3 Mab21L3 Mus musculus (Mouse) TR32528_c2_g1_i1 Q9Y106 MB21L_DROME 6.00E-07 GO:0045165 Q9W279; Q9VYX0; Q9W083 cell fate commitment IPR024799; IPR024810; Protein mab-21-like CG4766 Drosophila melanogaster (Fruit fly) TR32529_c0_g1_i1 Q6ZRS2 SRCAP_HUMAN 0 GO:0005524; GO:0003677; GO:0005794; GO:0004386; GO:0004402; GO:0019048; GO:0005634; GO:0043234; GO:0006357; GO:0003713; GO:0006351 "ATP binding; DNA binding; Golgi apparatus; helicase activity; histone acetyltransferase activity; modulation by virus of host morphology or physiology; nucleus; protein complex; regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcription, DNA-dependent" IPR020478; IPR017956; IPR014012; IPR014001; IPR001650; IPR027417; IPR000330; Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) SRCAP KIAA0309 Homo sapiens (Human) TR32533_c2_g1_i1 O14522 PTPRT_HUMAN 1.00E-56 GO:0045294; GO:0009986; GO:0045295; GO:0007156; GO:0016021; GO:0005886; GO:0004725; GO:0016790; GO:0007169 P62993; Q99K10; Q69ZK9; Q9CS84; Q6P9K9; Q16849 alpha-catenin binding; cell surface; gamma-catenin binding; homophilic cell adhesion; integral to membrane; plasma membrane; protein tyrosine phosphatase activity; thiolester hydrolase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) TR32535_c0_g1_i1 A9ULZ2 BIR7B_XENLA 8.00E-48 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) TR32536_c0_g1_i1 Q9GP32 ALF_ECHMU 0 GO:0004332; GO:0006096 fructose-bisphosphate aldolase activity; glycolysis IPR000741; IPR013785; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. Fructose-bisphosphate aldolase (EC 4.1.2.13) FBPA Echinococcus multilocularis TR32537_c3_g1_i1 O00303 EIF3F_HUMAN 2.00E-121 GO:0008234; GO:0005829; GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0006508; GO:0006446; GO:0003743 P21127; P55884; Q969P5; Q9Q2G4 cysteine-type peptidase activity; cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; proteolysis; regulation of translational initiation; translation initiation factor activity IPR027531; IPR000555; IPR024969; Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC 3.4.19.12) (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47) EIF3F EIF3S5 Homo sapiens (Human) TR32537_c3_g2_i1 Q5PR67 EI3HB_DANRE 9.00E-09 GO:0007420; GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0007507; GO:0006446; GO:0003743; GO:0006413 brain development; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; heart development; regulation of translational initiation; translation initiation factor activity; translational initiation IPR027524; IPR000555; Eukaryotic translation initiation factor 3 subunit H-B (eIF3h-B) (Eukaryotic translation initiation factor 3 subunit 3-B) (eIF-3-gamma-B) (eIF3 p40 subunit B) eif3hb eif3s3b zgc:123049 Danio rerio (Zebrafish) (Brachydanio rerio) TR32537_c3_g3_i1 O00303 EIF3F_HUMAN 6.00E-59 GO:0008234; GO:0005829; GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0006508; GO:0006446; GO:0003743 P21127; P55884; Q969P5; Q9Q2G4 cysteine-type peptidase activity; cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; proteolysis; regulation of translational initiation; translation initiation factor activity IPR027531; IPR000555; IPR024969; Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC 3.4.19.12) (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47) EIF3F EIF3S5 Homo sapiens (Human) TR32539_c3_g1_i2 Q59E55 NAB_DROME 1.00E-36 GO:0008283; GO:0007626; GO:0045892; GO:0014019; GO:0048666; GO:0005634; GO:0003712; GO:0006351; GO:0035222 Q9VI93; Q9VDZ3 "cell proliferation; locomotory behavior; negative regulation of transcription, DNA-dependent; neuroblast development; neuron development; nucleus; transcription cofactor activity; transcription, DNA-dependent; wing disc pattern formation" IPR006989; IPR006988; NGFI-A-binding protein homolog (dNAB) nab CG33545 Drosophila melanogaster (Fruit fly) TR32539_c7_g1_i1 Q59E55 NAB_DROME 9.00E-26 GO:0008283; GO:0007626; GO:0045892; GO:0014019; GO:0048666; GO:0005634; GO:0003712; GO:0006351; GO:0035222 Q9VI93; Q9VDZ3 "cell proliferation; locomotory behavior; negative regulation of transcription, DNA-dependent; neuroblast development; neuron development; nucleus; transcription cofactor activity; transcription, DNA-dependent; wing disc pattern formation" IPR006989; IPR006988; NGFI-A-binding protein homolog (dNAB) nab CG33545 Drosophila melanogaster (Fruit fly) TR32542_c0_g1_i1 O95402 MED26_HUMAN 4.00E-14 GO:0003677; GO:0001104; GO:0016592; GO:0003713; GO:0006367 Q96JC9 DNA binding; RNA polymerase II transcription cofactor activity; mediator complex; transcription coactivator activity; transcription initiation from RNA polymerase II promoter IPR003617; IPR017923; Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) MED26 ARC70 CRSP7 Homo sapiens (Human) TR32543_c1_g1_i2 Q91XP5 GLRA3_MOUSE 1.00E-45 GO:0030054; GO:0034707; GO:0016934; GO:0016594; GO:0005887; GO:0045211; GO:0022824 cell junction; chloride channel complex; extracellular-glycine-gated chloride channel activity; glycine binding; integral to plasma membrane; postsynaptic membrane; transmitter-gated ion channel activity IPR006028; IPR008127; IPR008130; IPR006202; IPR006201; IPR006029; IPR018000; Glycine receptor subunit alpha-3 Glra3 Mus musculus (Mouse) TR32543_c1_g1_i4 Q5JXX5 GLRA4_HUMAN 8.00E-43 GO:0030054; GO:0005254; GO:0034707; GO:0005230; GO:0016594; GO:0005887; GO:0045211; GO:0022824 cell junction; chloride channel activity; chloride channel complex; extracellular ligand-gated ion channel activity; glycine binding; integral to plasma membrane; postsynaptic membrane; transmitter-gated ion channel activity IPR006028; IPR008127; IPR006202; IPR006201; IPR006029; IPR018000; Glycine receptor subunit alpha-4 GLRA4 Homo sapiens (Human) TR32543_c1_g2_i1 Q7NDN8 GLIC_GLOVI 6.00E-09 GO:0005230; GO:0016021; GO:0005886; GO:0005267; GO:0005272; GO:0035725 extracellular ligand-gated ion channel activity; integral to membrane; plasma membrane; potassium channel activity; sodium channel activity; sodium ion transmembrane transport IPR006028; IPR006202; IPR006201; IPR006029; Proton-gated ion channel (GLIC) (Ligand-gated ion channel) (LGIC) glvI glr4197 Gloeobacter violaceus (strain PCC 7421) TR32543_c1_g2_i2 P49579 ACHB_XENLA 4.00E-09 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit beta (Fragment) chrnb1 Xenopus laevis (African clawed frog) TR32545_c3_g1_i2 P21180 CO2_MOUSE 2.00E-07 GO:0006958; GO:0005576; GO:0045087; GO:0006508; GO:0004252 "complement activation, classical pathway; extracellular region; innate immune response; proteolysis; serine-type endopeptidase activity" IPR011360; IPR001254; IPR018114; IPR001314; IPR000436; IPR009003; IPR002035; Complement C2 (EC 3.4.21.43) (C3/C5 convertase) [Cleaved into: Complement C2b fragment; Complement C2a fragment] C2 Mus musculus (Mouse) TR32545_c4_g1_i1 Q03710 CFAB_PIG 5.00E-09 GO:0006957; GO:0005576; GO:0006508; GO:0008236 "complement activation, alternative pathway; extracellular region; proteolysis; serine-type peptidase activity" IPR000436; Complement factor B (EC 3.4.21.47) (C3/C5 convertase) (Properdin factor B) (Fragment) CFB BF Sus scrofa (Pig) TR32545_c4_g1_i2 A2AVA0 SVEP1_MOUSE 3.00E-15 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)" Svep1 Mus musculus (Mouse) TR32546_c1_g1_i1 Q5F3J5 PSME3_CHICK 1.00E-79 GO:0008537 proteasome activator complex IPR009077; IPR003186; IPR003185; Proteasome activator complex subunit 3 (Activator of multicatalytic protease subunit 3) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma) PSME3 RCJMB04_15e19 RCJMB04_5i13 Gallus gallus (Chicken) TR32549_c5_g2_i1 Q9H5L6 THAP9_HUMAN 7.00E-12 GO:0015074; GO:0046872; GO:0043565; GO:0016740; GO:0004803; GO:0006313 "DNA integration; metal ion binding; sequence-specific DNA binding; transferase activity; transposase activity; transposition, DNA-mediated" IPR006612; DNA transposase THAP9 (EC 2.7.7.-) (THAP domain-containing protein 9) (hTh9) THAP9 Homo sapiens (Human) TR32549_c6_g1_i1 Q6IE62 PRS45_RAT 1.00E-09 GO:0005576; GO:0006508; GO:0004252 extracellular region; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Inactive serine protease 45 (Inactive testis serine protease 5) Prss45 Tessp5 Rattus norvegicus (Rat) TR32549_c6_g1_i2 P29786 TRY3_AEDAE 2.00E-23 GO:0007586; GO:0005615; GO:0006508; GO:0004252 digestion; extracellular space; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Trypsin 3A1 (EC 3.4.21.4) AAEL007818 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR32549_c6_g1_i3 P35005 TRYE_DROME 1.00E-28 GO:0005615; GO:0006508; GO:0004252 extracellular space; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Trypsin epsilon (EC 3.4.21.4) epsilonTry TRY-EPSILON CG18681 Drosophila melanogaster (Fruit fly) TR32550_c2_g1_i2 P54363 APT_DROPS 4.00E-58 GO:0044209; GO:0003999; GO:0006168; GO:0005737; GO:0006166 AMP salvage; adenine phosphoribosyltransferase activity; adenine salvage; cytoplasm; purine ribonucleoside salvage IPR005764; IPR000836; Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7) Aprt GA14884 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR32552_c1_g1_i1 Q5REW9 ANR27_PONAB 3.00E-103 GO:0005096; GO:0005737; GO:0043547 GTPase activator activity; cytoplasm; positive regulation of GTPase activity IPR002110; IPR020683; IPR003123; IPR013995; Ankyrin repeat domain-containing protein 27 ANKRD27 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR32552_c1_g2_i1 Q653P0 KOR1_ORYSJ 7.00E-13 GO:0016021; GO:0005249 integral to membrane; voltage-gated potassium channel activity IPR002110; IPR020683; IPR018490; IPR000595; IPR005821; IPR021789; IPR003938; IPR014710; Potassium channel KOR1 (K(+) outward-rectifying channel 1) Os06g0250600 LOC_Os06g14030 OSJNBa0091G06.35 P0431E05.11 Oryza sativa subsp. japonica (Rice) TR32552_c2_g1_i1 P16157 ANK1_HUMAN 2.00E-24 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR32552_c2_g1_i2 Q54HW1 PSD10_DICDI 3.00E-21 IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) psmD10 DDB_G0289189 Dictyostelium discoideum (Slime mold) TR32552_c2_g1_i4 O15084 ANR28_HUMAN 4.00E-18 GO:0005654 Q14185; O00743; Q9UPN7; O75170; Q5H9R7; Q9H2K2 nucleoplasm IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) ANKRD28 KIAA0379 Homo sapiens (Human) TR32553_c0_g1_i1 Q66I24 ASSY_DANRE 0 GO:0005524; GO:0006526; GO:0004055; GO:0000050 ATP binding; arginine biosynthetic process; argininosuccinate synthase activity; urea cycle IPR001518; IPR018223; IPR023434; IPR024074; IPR014729; Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1. Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) ass1 ass zgc:92051 Danio rerio (Zebrafish) (Brachydanio rerio) TR32553_c0_g1_i3 Q0IFL5 ASSY_AEDAE 2.00E-167 GO:0005524; GO:0006526; GO:0004055; GO:0000050 ATP binding; arginine biosynthetic process; argininosuccinate synthase activity; urea cycle IPR001518; IPR018223; IPR023434; IPR024074; IPR014729; Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1. Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) AAEL004701 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR32554_c2_g1_i1 Q9D3S3 SNX29_MOUSE 4.00E-87 GO:0007154; GO:0035091 cell communication; phosphatidylinositol binding IPR001683; IPR004012; Sorting nexin-29 Snx29 Mus musculus (Mouse) TR32555_c0_g1_i1 Q9ERE8 MESD1_MOUSE 1.00E-41 O75581 Mesoderm development candidate 1 Mesdc1 Mus musculus (Mouse) TR32555_c0_g1_i2 Q9ERE8 MESD1_MOUSE 1.00E-41 O75581 Mesoderm development candidate 1 Mesdc1 Mus musculus (Mouse) TR32556_c0_g1_i1 H2A0N4 PIF_PINMG 2.00E-24 GO:0008061; GO:0006030; GO:0005576 chitin binding; chitin metabolic process; extracellular region IPR002557; IPR002035; Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] Pinctada margaritifera (Black-lipped pearl oyster) TR32556_c0_g2_i1 P34576 MUA3_CAEEL 1.00E-12 GO:0005509; GO:0007155; GO:0030056; GO:0016021; GO:0005882; GO:0005886 calcium ion binding; cell adhesion; hemidesmosome; integral to membrane; intermediate filament; plasma membrane IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR002172; IPR000082; IPR002035; Transmembrane cell adhesion receptor mua-3 (Muscle attachment abnormal protein 3) mua-3 K08E5.3/T20G5.3 Caenorhabditis elegans TR32557_c0_g1_i1 Q6P158 DHX57_HUMAN 8.00E-14 GO:0005524; GO:0008026; GO:0046872; GO:0003676 ATP binding; ATP-dependent helicase activity; metal ion binding; nucleic acid binding IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; IPR006575; IPR009060; IPR015940; IPR000571; Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57) DHX57 Homo sapiens (Human) TR32557_c0_g2_i1 P43329 HRPA_ECOLI 8.00E-15 GO:0005524; GO:0004004; GO:0009451; GO:0006397; GO:0003676 ATP binding; ATP-dependent RNA helicase activity; RNA modification; mRNA processing; nucleic acid binding IPR003593; IPR011545; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; IPR024590; IPR010222; ATP-dependent RNA helicase HrpA (EC 3.6.4.13) hrpA b1413 JW5905 Escherichia coli (strain K12) TR32557_c1_g1_i1 Q9DBV3 DHX34_MOUSE 2.00E-111 GO:0005524; GO:0008026; GO:0003723 ATP binding; ATP-dependent helicase activity; RNA binding IPR011545; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; IPR015880; Probable ATP-dependent RNA helicase DHX34 (EC 3.6.4.13) (DEAH box protein 34) Dhx34 Ddx34 Kiaa0134 Mus musculus (Mouse) TR32558_c0_g1_i1 Q9JLI7 SPAG6_MOUSE 0 GO:0030030; GO:0005929; GO:0005737; GO:0005874; GO:0030317; GO:0007283 Q5S003 cell projection organization; cilium; cytoplasm; microtubule; sperm motility; spermatogenesis IPR011989; IPR016024; IPR000225; IPR000357; Sperm-associated antigen 6 (Axoneme central apparatus protein) (Protein PF16 homolog) Spag6 Pf16 Mus musculus (Mouse) TR32558_c0_g1_i2 Q9JLI7 SPAG6_MOUSE 2.00E-57 GO:0030030; GO:0005929; GO:0005737; GO:0005874; GO:0030317; GO:0007283 Q5S003 cell projection organization; cilium; cytoplasm; microtubule; sperm motility; spermatogenesis IPR011989; IPR016024; IPR000225; IPR000357; Sperm-associated antigen 6 (Axoneme central apparatus protein) (Protein PF16 homolog) Spag6 Pf16 Mus musculus (Mouse) TR32560_c2_g1_i1 A9UMP7 ENO4_XENLA 1.00E-49 GO:0006096; GO:0000287; GO:0004634; GO:0000015 glycolysis; magnesium ion binding; phosphopyruvate hydratase activity; phosphopyruvate hydratase complex IPR000941; IPR020810; IPR020811; Enolase-like protein ENO4 eno4 Xenopus laevis (African clawed frog) TR32560_c2_g1_i2 Q9BPL7 ENO2_TOXGO 9.00E-18 GO:0006096; GO:0000287; GO:0004634; GO:0000015 glycolysis; magnesium ion binding; phosphopyruvate hydratase activity; phosphopyruvate hydratase complex IPR000941; IPR020810; IPR020809; IPR020811; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5. Enolase 2 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase 2) (2-phosphoglycerate dehydratase 2) ENO2 Toxoplasma gondii TR32561_c4_g1_i2 Q9H0H5 RGAP1_HUMAN 9.00E-91 GO:0005096; GO:0001669; GO:0043014; GO:0019886; GO:0048487; GO:0007596; GO:0097149; GO:0032154; GO:0000915; GO:0007108; GO:0005829; GO:0009790; GO:0043015; GO:0046872; GO:0005874; GO:0008017; GO:0007018; GO:0030496; GO:0007405; GO:0005634; GO:0032467; GO:0051988; GO:0051056; GO:0007264; GO:0007283; GO:0051233; GO:0051256; GO:0008272 Q02241; Q16537; O75154; Q96RN1 "GTPase activator activity; acrosomal vesicle; alpha-tubulin binding; antigen processing and presentation of exogenous peptide antigen via MHC class II; beta-tubulin binding; blood coagulation; centralspindlin complex; cleavage furrow; cytokinesis, actomyosin contractile ring assembly; cytokinesis, initiation of separation; cytosol; embryo development; gamma-tubulin binding; metal ion binding; microtubule; microtubule binding; microtubule-based movement; midbody; neuroblast proliferation; nucleus; positive regulation of cytokinesis; regulation of attachment of spindle microtubules to kinetochore; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; spermatogenesis; spindle midzone; spindle midzone assembly involved in mitosis; sulfate transport" IPR002219; IPR008936; IPR000198; Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) RACGAP1 KIAA1478 MGCRACGAP Homo sapiens (Human) TR32561_c4_g1_i3 P40809 RG84C_DROME 6.00E-42 GO:0005096; GO:0030154; GO:0001745; GO:0005085; GO:0005622; GO:0035556; GO:0046872; GO:0007283 GTPase activator activity; cell differentiation; compound eye morphogenesis; guanyl-nucleotide exchange factor activity; intracellular; intracellular signal transduction; metal ion binding; spermatogenesis IPR002219; IPR008936; IPR000198; GTPase-activating protein RacGAP84C (Protein rotund RacGAP) RacGAP84C rnRacGAP CG2595 Drosophila melanogaster (Fruit fly) TR32561_c4_g1_i5 Q80XD1 CHIO_MOUSE 2.00E-22 GO:0005096; GO:0005622; GO:0035556; GO:0016020; GO:0046872; GO:0043547 GTPase activator activity; intracellular; intracellular signal transduction; membrane; metal ion binding; positive regulation of GTPase activity IPR020454; IPR002219; IPR008936; IPR000198; Beta-chimaerin (Beta-chimerin) (Rho GTPase-activating protein 3) Chn2 Arhgap3 Bch Mus musculus (Mouse) TR32561_c4_g1_i7 Q9H0H5 RGAP1_HUMAN 7.00E-91 GO:0005096; GO:0001669; GO:0043014; GO:0019886; GO:0048487; GO:0007596; GO:0097149; GO:0032154; GO:0000915; GO:0007108; GO:0005829; GO:0009790; GO:0043015; GO:0046872; GO:0005874; GO:0008017; GO:0007018; GO:0030496; GO:0007405; GO:0005634; GO:0032467; GO:0051988; GO:0051056; GO:0007264; GO:0007283; GO:0051233; GO:0051256; GO:0008272 Q02241; Q16537; O75154; Q96RN1 "GTPase activator activity; acrosomal vesicle; alpha-tubulin binding; antigen processing and presentation of exogenous peptide antigen via MHC class II; beta-tubulin binding; blood coagulation; centralspindlin complex; cleavage furrow; cytokinesis, actomyosin contractile ring assembly; cytokinesis, initiation of separation; cytosol; embryo development; gamma-tubulin binding; metal ion binding; microtubule; microtubule binding; microtubule-based movement; midbody; neuroblast proliferation; nucleus; positive regulation of cytokinesis; regulation of attachment of spindle microtubules to kinetochore; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; spermatogenesis; spindle midzone; spindle midzone assembly involved in mitosis; sulfate transport" IPR002219; IPR008936; IPR000198; Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) RACGAP1 KIAA1478 MGCRACGAP Homo sapiens (Human) TR32564_c0_g1_i2 A6NC05 YD286_HUMAN 6.00E-26 GO:0005739; GO:0055114 mitochondrion; oxidation-reduction process IPR008554; IPR012336; Glutaredoxin-like protein C5orf63 C5orf63 Homo sapiens (Human) TR32564_c0_g1_i4 Q9CWB7 YD286_MOUSE 6.00E-27 GO:0005739; GO:0055114 mitochondrion; oxidation-reduction process IPR008554; IPR012336; Glutaredoxin-like protein C5orf63 homolog Mus musculus (Mouse) TR32567_c0_g1_i1 Q6LY06 FUCA_METMP 2.00E-06 GO:0008738; GO:0019317; GO:0046872 L-fuculose-phosphate aldolase activity; fucose catabolic process; metal ion binding IPR001303; Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 3/3. Cofactor biosynthesis; coenzyme F420 biosynthesis. L-fuculose phosphate aldolase (EC 4.1.2.17) (L-fuculose-1-phosphate aldolase) fucA MMP1187 Methanococcus maripaludis (strain S2 / LL) TR32567_c1_g1_i2 Q5ZLP2 MTNB_CHICK 6.00E-87 GO:0019284; GO:0019509; GO:0006915; GO:0005737; GO:0046570; GO:0008270 L-methionine biosynthetic process from S-adenosylmethionine; L-methionine salvage from methylthioadenosine; apoptotic process; cytoplasm; methylthioribulose 1-phosphate dehydratase activity; zinc ion binding IPR001303; IPR017714; IPR027514; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC 4.2.1.109) (APAF1-interacting protein homolog) APIP RCJMB04_5f12 Gallus gallus (Chicken) TR32568_c0_g1_i2 Q5UQW1 YL376_MIMIV 5.00E-09 GO:0003899; GO:0006351; GO:0019012 "DNA-directed RNA polymerase activity; transcription, DNA-dependent; virion" IPR012340; IPR022967; IPR005576; Putative DNA-directed RNA polymerase subunit L376 (EC 2.7.7.6) MIMI_L376 Acanthamoeba polyphaga mimivirus (APMV) TR32568_c0_g1_i3 Q7ZW41 RPB7_DANRE 1.00E-111 GO:0005665; GO:0003899; GO:0003723; GO:0006366 "DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase activity; RNA binding; transcription from RNA polymerase II promoter" IPR012340; IPR003029; IPR022967; IPR005576; DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) polr2g polr2gl zgc:55297 Danio rerio (Zebrafish) (Brachydanio rerio) TR3257_c0_g1_i1 Q09139 FABP7_BOVIN 7.00E-10 GO:0042995; GO:0021846; GO:0005737; GO:0008289; GO:0022008; GO:0043025; GO:0060134; GO:0005215 cell projection; cell proliferation in forebrain; cytoplasm; lipid binding; neurogenesis; neuronal cell body; prepulse inhibition; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; "Fatty acid-binding protein, brain (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7)" FABP7 Bos taurus (Bovine) TR32570_c0_g1_i2 Q51330 OXLT_OXAFO 2.00E-14 GO:0015297; GO:0016021; GO:0006811; GO:0005886 antiporter activity; integral to membrane; ion transport; plasma membrane IPR011701; IPR020846; IPR016196; IPR026355; IPR004741; Oxalate:formate antiporter (OFA) (Oxalate:formate antiport protein) (Oxalate:formate exchange protein) oxlT Oxalobacter formigenes TR32573_c2_g1_i1 O61577 KTNA1_STRPU 0 GO:0005524; GO:0051301; GO:0005737; GO:0005874; GO:0005815; GO:0008568; GO:0030496; GO:0007067; GO:0000922 ATP binding; cell division; cytoplasm; microtubule; microtubule organizing center; microtubule-severing ATPase activity; midbody; mitosis; spindle pole IPR003593; IPR003959; IPR003960; IPR027417; Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 3.6.4.3) (p60 katanin) KATNA1 Strongylocentrotus purpuratus (Purple sea urchin) TR32573_c2_g1_i2 O61577 KTNA1_STRPU 0 GO:0005524; GO:0051301; GO:0005737; GO:0005874; GO:0005815; GO:0008568; GO:0030496; GO:0007067; GO:0000922 ATP binding; cell division; cytoplasm; microtubule; microtubule organizing center; microtubule-severing ATPase activity; midbody; mitosis; spindle pole IPR003593; IPR003959; IPR003960; IPR027417; Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 3.6.4.3) (p60 katanin) KATNA1 Strongylocentrotus purpuratus (Purple sea urchin) TR32573_c2_g1_i3 A0JMA9 KATL2_XENTR 3.00E-86 GO:0005524; GO:0005737; GO:0005874; GO:0051013; GO:0008568 ATP binding; cytoplasm; microtubule; microtubule severing; microtubule-severing ATPase activity IPR003593; IPR003959; IPR027497; IPR006594; IPR013720; IPR027417; Katanin p60 ATPase-containing subunit A-like 2 (Katanin p60 subunit A-like 2) (EC 3.6.4.3) (p60 katanin-like 2) katnal2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR32573_c2_g1_i4 O74894 PRS6B_SCHPO 1.00E-31 GO:0005524; GO:0016887; GO:0005829; GO:0005634; GO:0008540; GO:0006511 "ATP binding; ATPase activity; cytosol; nucleus; proteasome regulatory particle, base subcomplex; ubiquitin-dependent protein catabolic process" IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 6B homolog rpt3 SPCC576.10c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR32575_c2_g1_i2 Q803I2 ERGI3_DANRE 5.00E-76 GO:0005794; GO:0005789; GO:0033116; GO:0016021; GO:0016192 Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; vesicle-mediated transport IPR012936; Endoplasmic reticulum-Golgi intermediate compartment protein 3 ergic3 zgc:113959 zgc:55762 Danio rerio (Zebrafish) (Brachydanio rerio) TR32575_c3_g1_i2 Q5EAE0 ERGI3_BOVIN 2.00E-74 GO:0005794; GO:0005789; GO:0033116; GO:0016021; GO:0016192 Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; vesicle-mediated transport IPR012936; Endoplasmic reticulum-Golgi intermediate compartment protein 3 ERGIC3 Bos taurus (Bovine) TR32575_c4_g1_i2 Q4V8Y6 ERGI1_DANRE 7.00E-19 GO:0000139; GO:0005789; GO:0033116; GO:0016021; GO:0016192 Golgi membrane; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; vesicle-mediated transport IPR012936; Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ER-Golgi intermediate compartment 32 kDa protein) (ERGIC-32) ergic1 ergic32 zgc:114085 Danio rerio (Zebrafish) (Brachydanio rerio) TR32582_c2_g4_i1 Q5RJI4 PKDCC_MOUSE 9.00E-25 GO:0005524; GO:0005794; GO:0030282; GO:0030154; GO:0048566; GO:0048286; GO:0035264; GO:0042997; GO:0060021; GO:0030501; GO:0032332; GO:0004672; GO:0015031; GO:0001501 ATP binding; Golgi apparatus; bone mineralization; cell differentiation; embryonic digestive tract development; lung alveolus development; multicellular organism growth; negative regulation of Golgi to plasma membrane protein transport; palate development; positive regulation of bone mineralization; positive regulation of chondrocyte differentiation; protein kinase activity; protein transport; skeletal system development IPR022049; IPR011009; IPR000719; "Protein kinase domain-containing protein, cytoplasmic (EC 2.7.-.-) (Protein kinase-like protein SgK493) (Sugen kinase 493) (Vertebrate lonesome kinase)" Pkdcc Sgk493 Vlk Mus musculus (Mouse) TR32587_c0_g2_i1 Q6TAC8 C3AR_MACFA 4.00E-10 GO:0004943; GO:0004982; GO:0006935; GO:0016021; GO:0005886 C3a anaphylatoxin receptor activity; N-formyl peptide receptor activity; chemotaxis; integral to membrane; plasma membrane IPR001644; IPR002234; IPR000826; IPR000276; IPR017452; C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R) C3AR1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR32590_c0_g1_i1 C5P447 AIM31_COCP7 1.00E-07 GO:0016021; GO:0031966 integral to membrane; mitochondrial membrane IPR007667; "Respiratory supercomplex factor 1, mitochondrial" RCF1 AIM31 CPC735_063380 Coccidioides posadasii (strain C735) (Valley fever fungus) TR32592_c2_g3_i1 Q9BQ50 TREX2_HUMAN 5.00E-26 GO:0008296; GO:0006281; GO:0008853; GO:0000287; GO:0003676; GO:0005634 3'-5'-exodeoxyribonuclease activity; DNA repair; exodeoxyribonuclease III activity; magnesium ion binding; nucleic acid binding; nucleus IPR006055; IPR013520; IPR012337; Three prime repair exonuclease 2 (EC 3.1.11.2) (3'-5' exonuclease TREX2) TREX2 Homo sapiens (Human) TR32594_c0_g1_i1 Q9JM76 ARPC3_MOUSE 3.00E-85 GO:0034314; GO:0005885; GO:0005737; GO:0030027 Arp2/3 complex-mediated actin nucleation; Arp2/3 protein complex; cytoplasm; lamellipodium IPR007204; Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC) Arpc3 Mus musculus (Mouse) TR32594_c0_g1_i2 Q9JM76 ARPC3_MOUSE 4.00E-85 GO:0034314; GO:0005885; GO:0005737; GO:0030027 Arp2/3 complex-mediated actin nucleation; Arp2/3 protein complex; cytoplasm; lamellipodium IPR007204; Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC) Arpc3 Mus musculus (Mouse) TR32595_c0_g1_i1 Q6TNS2 PK1IP_DANRE 2.00E-81 GO:0009968; GO:0005730 negative regulation of signal transduction; nucleolus IPR015943; IPR001680; IPR019775; IPR017986; p21-activated protein kinase-interacting protein 1-like (PAK1-interacting protein 1-like) pak1ip1 zgc:56683 Danio rerio (Zebrafish) (Brachydanio rerio) TR32596_c1_g1_i1 P57075 UBS3A_HUMAN 4.00E-51 GO:0003824; GO:0005829; GO:0008152; GO:0050860; GO:0005634; GO:0001817 catalytic activity; cytosol; metabolic process; negative regulation of T cell receptor signaling pathway; nucleus; regulation of cytokine production IPR013078; IPR009097; IPR001452; IPR009060; IPR015940; Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1) UBASH3A STS2 Homo sapiens (Human) TR32596_c1_g1_i2 Q8TF42 UBS3B_HUMAN 5.00E-89 GO:0005737; GO:0090331; GO:0006469; GO:0005634; GO:0004725; GO:0051279 P43405 cytoplasm; negative regulation of platelet aggregation; negative regulation of protein kinase activity; nucleus; protein tyrosine phosphatase activity; regulation of release of sequestered calcium ion into cytosol IPR013078; IPR001452; IPR009060; IPR015940; IPR000449; Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2) UBASH3B KIAA1959 STS1 Homo sapiens (Human) TR32598_c1_g1_i2 Q9Y5X3 SNX5_HUMAN 2.00E-18 GO:0007154; GO:0030659; GO:0031901; GO:0031313; GO:0031234; GO:0070685; GO:0001891; GO:0035091; GO:0006907; GO:0015031; GO:0001726 cell communication; cytoplasmic vesicle membrane; early endosome membrane; extrinsic to endosome membrane; extrinsic to internal side of plasma membrane; macropinocytic cup; phagocytic cup; phosphatidylinositol binding; pinocytosis; protein transport; ruffle IPR001683; IPR014637; IPR015404; Sorting nexin-5 SNX5 Homo sapiens (Human) TR32599_c2_g1_i1 Q6IMM1 DJC27_CHICK 6.00E-14 GO:0005525; GO:0005739; GO:0007264 GTP binding; mitochondrion; small GTPase mediated signal transduction IPR001623; IPR027417; IPR005225; IPR001806; DnaJ homolog subfamily C member 27 (Rab and DnaJ domain-containing protein) DNAJC27 RBJ Gallus gallus (Chicken) TR32603_c1_g1_i1 B4LKS9 BOP1_DROVI 3.00E-08 GO:0005730; GO:0005654; GO:0006364 nucleolus; nucleoplasm; rRNA processing IPR012953; IPR015943; IPR001680; IPR019775; IPR017986; Ribosome biogenesis protein BOP1 homolog GJ22246 Drosophila virilis (Fruit fly) TR32603_c3_g1_i1 Q9D994 WDR38_MOUSE 1.00E-59 IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 38 Wdr38 Mus musculus (Mouse) TR32604_c12_g1_i1 B2RXS4 PLXB2_MOUSE 1.00E-14 GO:0007420; GO:0005887; GO:0005622; GO:0001843; GO:0007405; GO:0050772; GO:0032319; GO:0008360; GO:2001222; GO:0001932; GO:0017154 Q68FM7 brain development; integral to plasma membrane; intracellular; neural tube closure; neuroblast proliferation; positive regulation of axonogenesis; regulation of Rho GTPase activity; regulation of cell shape; regulation of neuron migration; regulation of protein phosphorylation; semaphorin receptor activity IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-B2 Plxnb2 Mus musculus (Mouse) TR32605_c0_g1_i1 B0TAH2 DUT_HELMI 6.00E-28 GO:0006226; GO:0004170; GO:0046080; GO:0000287 dUMP biosynthetic process; dUTP diphosphatase activity; dUTP metabolic process; magnesium ion binding IPR008180; IPR008181; Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) dut Helmi_23970 HM1_2472 Heliobacterium modesticaldum (strain ATCC 51547 / Ice1) TR32605_c0_g1_i2 P33316 DUT_HUMAN 7.00E-70 GO:0006260; GO:0006226; GO:0004170; GO:0046080; GO:0005739; GO:0005654; GO:0006206; GO:0046134 Q6ZVK8 DNA replication; dUMP biosynthetic process; dUTP diphosphatase activity; dUTP metabolic process; mitochondrion; nucleoplasm; pyrimidine nucleobase metabolic process; pyrimidine nucleoside biosynthetic process IPR008180; IPR008181; Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)" DUT Homo sapiens (Human) TR32605_c0_g1_i3 Q10FF9 DUT_ORYSJ 2.00E-55 GO:0006226; GO:0004170; GO:0046080; GO:0046872 dUMP biosynthetic process; dUTP diphosphatase activity; dUTP metabolic process; metal ion binding IPR008180; IPR008181; Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) DUT Os03g0669100 LOC_Os03g46640 OSJNBa0039O18.10 Oryza sativa subsp. japonica (Rice) TR32606_c0_g1_i1 P20393 NR1D1_HUMAN 1.00E-16 GO:0071222; GO:0007623; GO:0004879; GO:0010871; GO:0034144; GO:0000122; GO:0000790; GO:0005654; GO:0043565; GO:0003707; GO:0003714; GO:0006367; GO:0044212; GO:0008270 cellular response to lipopolysaccharide; circadian rhythm; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; negative regulation of receptor biosynthetic process; negative regulation of toll-like receptor 4 signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; nucleoplasm; sequence-specific DNA binding; steroid hormone receptor activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; transcription regulatory region DNA binding; zinc ion binding IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1) NR1D1 EAR1 HREV THRAL Homo sapiens (Human) TR32606_c0_g1_i2 Q05192 FTF1B_DROME 2.00E-46 GO:0000978; GO:0006919; GO:0035072; GO:0016321; GO:0004879; GO:0045433; GO:0005634; GO:0060968; GO:0035211; GO:0003707; GO:0008270 Q86BY9; O96757 "RNA polymerase II core promoter proximal region sequence-specific DNA binding; activation of cysteine-type endopeptidase activity involved in apoptotic process; ecdysone-mediated induction of salivary gland cell autophagic cell death; female meiosis chromosome segregation; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; male courtship behavior, veined wing generated song production; nucleus; regulation of gene silencing; spermathecum morphogenesis; steroid hormone receptor activity; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Nuclear hormone receptor FTZ-F1 beta (Nuclear hormone receptor HR39) (dHR39) (Nuclear receptor subfamily 5 group B member 1) Hr39 FTZ-F1-beta FTZF1-beta NR5-beta-1 NR5B1 CG8676 Drosophila melanogaster (Fruit fly) TR32609_c0_g1_i1 Q8CIM1 LRC45_MOUSE 5.00E-08 GO:0005813 centrosome Leucine-rich repeat-containing protein 45 Lrrc45 Mus musculus (Mouse) TR32609_c1_g2_i2 Q6ZQY2 YV012_HUMAN 3.00E-19 Leucine-rich repeat-containing protein LOC400891 Homo sapiens (Human) TR3261_c0_g1_i1 Q8IVF4 DYH10_HUMAN 4.00E-51 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 10, axonemal (Axonemal beta dynein heavy chain 10) (Ciliary dynein heavy chain 10)" DNAH10 KIAA2017 Homo sapiens (Human) TR32610_c0_g2_i1 Q9ERS5 PKHA2_MOUSE 5.00E-55 GO:0005545; GO:0005737; GO:0005634; GO:0005886 O75970 1-phosphatidylinositol binding; cytoplasm; nucleus; plasma membrane IPR011993; IPR001849; Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (PH domain-containing adaptor PHAD47) (Tandem PH domain-containing protein 2) (TAPP-2) Plekha2 Tapp2 Mus musculus (Mouse) TR32610_c0_g2_i2 Q14644 RASA3_HUMAN 4.00E-06 GO:0005099; GO:0015278; GO:0005737; GO:0035556; GO:0031235; GO:0046872; GO:0046580; GO:0005543; GO:0007165 Ras GTPase activator activity; calcium-release channel activity; cytoplasm; intracellular signal transduction; intrinsic to internal side of plasma membrane; metal ion binding; negative regulation of Ras protein signal transduction; phospholipid binding; signal transduction IPR000008; IPR011993; IPR001849; IPR001936; IPR023152; IPR008936; IPR001562; Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) RASA3 Homo sapiens (Human) TR32610_c0_g2_i3 Q9HB21 PKHA1_HUMAN 2.00E-59 GO:0050853; GO:0033327; GO:0008209; GO:0070301; GO:0005737; GO:0045184; GO:0008210; GO:0060325; GO:0001553; GO:0035264; GO:0051898; GO:0005634; GO:0060021; GO:0014065; GO:0043325; GO:0048008; GO:0009791; GO:0032587; GO:0031529; GO:0048705; GO:0007283 O75970; Q9P0V3 "B cell receptor signaling pathway; Leydig cell differentiation; androgen metabolic process; cellular response to hydrogen peroxide; cytoplasm; establishment of protein localization; estrogen metabolic process; face morphogenesis; luteinization; multicellular organism growth; negative regulation of protein kinase B signaling cascade; nucleus; palate development; phosphatidylinositol 3-kinase cascade; phosphatidylinositol-3,4-bisphosphate binding; platelet-derived growth factor receptor signaling pathway; post-embryonic development; ruffle membrane; ruffle organization; skeletal system morphogenesis; spermatogenesis" IPR011993; IPR001849; Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1) PLEKHA1 TAPP1 Homo sapiens (Human) TR32610_c0_g2_i4 Q9UN19 DAPP1_HUMAN 4.00E-10 GO:0005829; GO:0005547; GO:0043325; GO:0005886; GO:0004725; GO:0007165 "cytosol; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; plasma membrane; protein tyrosine phosphatase activity; signal transduction" IPR011993; IPR001849; IPR000980; Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa) DAPP1 BAM32 HSPC066 Homo sapiens (Human) TR32610_c0_g2_i6 Q9ERS5 PKHA2_MOUSE 8.00E-55 GO:0005545; GO:0005737; GO:0005634; GO:0005886 O75970 1-phosphatidylinositol binding; cytoplasm; nucleus; plasma membrane IPR011993; IPR001849; Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (PH domain-containing adaptor PHAD47) (Tandem PH domain-containing protein 2) (TAPP-2) Plekha2 Tapp2 Mus musculus (Mouse) TR32610_c0_g2_i7 Q9HB21 PKHA1_HUMAN 6.00E-56 GO:0050853; GO:0033327; GO:0008209; GO:0070301; GO:0005737; GO:0045184; GO:0008210; GO:0060325; GO:0001553; GO:0035264; GO:0051898; GO:0005634; GO:0060021; GO:0014065; GO:0043325; GO:0048008; GO:0009791; GO:0032587; GO:0031529; GO:0048705; GO:0007283 O75970; Q9P0V3 "B cell receptor signaling pathway; Leydig cell differentiation; androgen metabolic process; cellular response to hydrogen peroxide; cytoplasm; establishment of protein localization; estrogen metabolic process; face morphogenesis; luteinization; multicellular organism growth; negative regulation of protein kinase B signaling cascade; nucleus; palate development; phosphatidylinositol 3-kinase cascade; phosphatidylinositol-3,4-bisphosphate binding; platelet-derived growth factor receptor signaling pathway; post-embryonic development; ruffle membrane; ruffle organization; skeletal system morphogenesis; spermatogenesis" IPR011993; IPR001849; Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1) PLEKHA1 TAPP1 Homo sapiens (Human) TR32614_c9_g1_i2 O43490 PROM1_HUMAN 4.00E-07 GO:0042805; GO:0016324; GO:0005903; GO:0060219; GO:0009986; GO:0005615; GO:0072139; GO:0072112; GO:0005887; GO:0031528; GO:0045494; GO:0042622; GO:0005886; GO:2000768; GO:0010842; GO:0032420 Q8VHP6 actinin binding; apical plasma membrane; brush border; camera-type eye photoreceptor cell differentiation; cell surface; extracellular space; glomerular parietal epithelial cell differentiation; glomerular visceral epithelial cell differentiation; integral to plasma membrane; microvillus membrane; photoreceptor cell maintenance; photoreceptor outer segment membrane; plasma membrane; positive regulation of nephron tubule epithelial cell differentiation; retina layer formation; stereocilium IPR008795; Prominin-1 (Antigen AC133) (Prominin-like protein 1) (CD antigen CD133) PROM1 PROML1 MSTP061 Homo sapiens (Human) TR32619_c4_g1_i1 Q8JHV9 BIR7A_XENLA 7.00E-36 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR32619_c4_g1_i2 Q96CA5 BIRC7_HUMAN 4.00E-34 GO:0005794; GO:0007257; GO:0006309; GO:0004869; GO:0019899; GO:0043066; GO:0005634; GO:0042127; GO:0070247; GO:0004842; GO:0008270 P55211; Q9NR28; O43464 Golgi apparatus; activation of JUN kinase activity; apoptotic DNA fragmentation; cysteine-type endopeptidase inhibitor activity; enzyme binding; negative regulation of apoptotic process; nucleus; regulation of cell proliferation; regulation of natural killer cell apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; IPR017907; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)] BIRC7 KIAP LIVIN MLIAP RNF50 UNQ5800/PRO19607/PRO21344 Homo sapiens (Human) TR32620_c3_g1_i1 P13387 EGFR_CHICK 4.00E-33 GO:0005524; GO:0000139; GO:0005789; GO:0010008; GO:0016021; GO:0031965; GO:0005634; GO:0005886; GO:0004713; GO:0004714; GO:0007169 ATP binding; Golgi membrane; endoplasmic reticulum membrane; endosome membrane; integral to membrane; nuclear membrane; nucleus; plasma membrane; protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000494; IPR006211; IPR006212; IPR009030; Epidermal growth factor receptor (CER) (EC 2.7.10.1) (Fragment) EGFR Gallus gallus (Chicken) TR32620_c7_g1_i1 Q80T14 FRAS1_MOUSE 8.00E-12 GO:0005604; GO:0007154; GO:0016021; GO:0046872; GO:0002009; GO:0005886; GO:0015031; GO:0043588 basement membrane; cell communication; integral to membrane; metal ion binding; morphogenesis of an epithelium; plasma membrane; protein transport; skin development IPR003644; IPR006212; IPR009030; IPR001007; Extracellular matrix protein FRAS1 Fras1 Kiaa1500 Mus musculus (Mouse) TR32620_c7_g1_i2 P0CY46 EGFR_APIME 3.00E-55 GO:0005524; GO:0016021; GO:0007275; GO:0018108; GO:0004714; GO:0007169 ATP binding; integral to membrane; multicellular organismal development; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000494; IPR006211; IPR006212; IPR009030; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Epidermal growth factor receptor (Egfr) (EC 2.7.10.1) Egfr Apis mellifera (Honeybee) TR32620_c7_g1_i3 P0CY46 EGFR_APIME 4.00E-53 GO:0005524; GO:0016021; GO:0007275; GO:0018108; GO:0004714; GO:0007169 ATP binding; integral to membrane; multicellular organismal development; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000494; IPR006211; IPR006212; IPR009030; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Epidermal growth factor receptor (Egfr) (EC 2.7.10.1) Egfr Apis mellifera (Honeybee) TR32622_c0_g1_i3 Q5UR67 YR617_MIMIV 2.00E-19 IPR012816; Uncharacterized protein R617 MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) TR32623_c0_g1_i1 P20009 DLL_DROME 2.00E-34 GO:0007487; GO:0007469; GO:0048264; GO:0007480; GO:0007485; GO:0008587; GO:0007479; GO:0016319; GO:0010629; GO:0005634; GO:0042048; GO:0021553; GO:0045893; GO:0048728; GO:0003700; GO:0010092; GO:0000976; GO:0006351 "analia development; antennal development; determination of ventral identity; imaginal disc-derived leg morphogenesis; imaginal disc-derived male genitalia development; imaginal disc-derived wing margin morphogenesis; leg disc proximal/distal pattern formation; mushroom body development; negative regulation of gene expression; nucleus; olfactory behavior; olfactory nerve development; positive regulation of transcription, DNA-dependent; proboscis development; sequence-specific DNA binding transcription factor activity; specification of organ identity; transcription regulatory region sequence-specific DNA binding; transcription, DNA-dependent" IPR017970; IPR001356; IPR020479; IPR009057; IPR000047; Homeotic protein distal-less (Protein brista) Dll Ba BR CG3629 Drosophila melanogaster (Fruit fly) TR32624_c4_g1_i3 Q9WVS8 MK07_MOUSE 4.00E-35 GO:0005524; GO:0004707; GO:0000165; GO:0016605; GO:0007049; GO:0030154; GO:0070301; GO:0071560; GO:0005829; GO:0051534; GO:0043066; GO:2000352; GO:2001240; GO:0034115; GO:1902176; GO:0060761; GO:0018105; GO:0051247; GO:0036003; GO:0004674; GO:0045765 ATP binding; MAP kinase activity; MAPK cascade; PML body; cell cycle; cell differentiation; cellular response to hydrogen peroxide; cellular response to transforming growth factor beta stimulus; cytosol; negative regulation of NFAT protein import into nucleus; negative regulation of apoptotic process; negative regulation of endothelial cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of heterotypic cell-cell adhesion; negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress; negative regulation of response to cytokine stimulus; peptidyl-serine phosphorylation; positive regulation of protein metabolic process; positive regulation of transcription from RNA polymerase II promoter in response to stress; protein serine/threonine kinase activity; regulation of angiogenesis IPR011009; IPR003527; IPR000719; IPR017441; IPR002290; IPR008271; Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) Mapk7 Bmk1 Erk5 Mus musculus (Mouse) TR32626_c0_g1_i4 P74148 Y1388_SYNY3 5.00E-07 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein Sll1388 (USP Sll1388) sll1388 Synechocystis sp. (strain PCC 6803 / Kazusa) TR32628_c2_g1_i3 Q9VLJ8 MOCS3_DROME 7.00E-06 GO:0005524; GO:0006777; GO:0005829; GO:0046872; GO:0008033; GO:0004792 ATP binding; Mo-molybdopterin cofactor biosynthetic process; cytosol; metal ion binding; tRNA processing; thiosulfate sulfurtransferase activity IPR007901; IPR009036; IPR016040; IPR001763; IPR000594; tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. Cofactor biosynthesis; molybdopterin biosynthesis. Adenylyltransferase and sulfurtransferase MOCS3 (Molybdenum cofactor synthesis protein 3) [Includes: Molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) (Adenylyltransferase MOCS3) (Sulfur carrier protein MOCS2A adenylyltransferase); Molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) (Sulfur carrier protein MOCS2A sulfurtransferase) (Sulfurtransferase MOCS3)] CG13090 Drosophila melanogaster (Fruit fly) TR32629_c12_g1_i1 Q8IYE1 CCD13_HUMAN 3.00E-06 Coiled-coil domain-containing protein 13 CCDC13 Homo sapiens (Human) TR32629_c3_g1_i1 P0CR30 SAR1_CRYNJ 2.00E-13 GO:0012507; GO:0005525; GO:0000139; GO:0005789; GO:0016787; GO:0006886; GO:0016192 ER to Golgi transport vesicle membrane; GTP binding; Golgi membrane; endoplasmic reticulum membrane; hydrolase activity; intracellular protein transport; vesicle-mediated transport IPR027417; IPR005225; IPR006689; IPR006687; Small COPII coat GTPase SAR1 (EC 3.6.5.-) SAR1 CNB03430 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR32629_c4_g1_i1 Q8IYE1 CCD13_HUMAN 9.00E-19 Coiled-coil domain-containing protein 13 CCDC13 Homo sapiens (Human) TR32631_c0_g2_i1 Q6R5J2 DISP1_DANRE 6.00E-12 GO:0021984; GO:0009952; GO:0008015; GO:0048701; GO:0008158; GO:0048839; GO:0016021; GO:0042694; GO:0031290; GO:0007519; GO:0007224 adenohypophysis development; anterior/posterior pattern specification; blood circulation; embryonic cranial skeleton morphogenesis; hedgehog receptor activity; inner ear development; integral to membrane; muscle cell fate specification; retinal ganglion cell axon guidance; skeletal muscle tissue development; smoothened signaling pathway IPR003392; IPR000731; Protein dispatched homolog 1 (Protein chameleon) disp1 con Danio rerio (Zebrafish) (Brachydanio rerio) TR32631_c3_g1_i1 Q96F81 DISP1_HUMAN 1.00E-32 GO:0016323; GO:0007368; GO:0060539; GO:0009953; GO:0009880; GO:0008158; GO:0016021; GO:0007225; GO:0015197; GO:0070207; GO:0050708; GO:0007224 basolateral plasma membrane; determination of left/right symmetry; diaphragm development; dorsal/ventral pattern formation; embryonic pattern specification; hedgehog receptor activity; integral to membrane; patched ligand maturation; peptide transporter activity; protein homotrimerization; regulation of protein secretion; smoothened signaling pathway IPR003392; IPR000731; Protein dispatched homolog 1 DISP1 DISPA Homo sapiens (Human) TR32632_c0_g1_i1 P36508 ZNF76_HUMAN 2.00E-136 GO:0003677; GO:0046872; GO:0005634; GO:0006357; GO:0006359; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase III promoter; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 76 (Zinc finger protein 523) ZNF76 D6S229E ZNF523 Homo sapiens (Human) TR32632_c0_g1_i2 Q8BMU0 ZNF76_MOUSE 2.00E-134 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 76 (Zinc finger protein 523) Znf76 Zfp523 Mus musculus (Mouse) TR32632_c0_g1_i6 P52747 ZN143_HUMAN 1.00E-131 GO:0003677; GO:0046872; GO:0005654; GO:0006357; GO:0006359; GO:0006366; GO:0006383 DNA binding; metal ion binding; nucleoplasm; regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase III promoter; transcription from RNA polymerase II promoter; transcription from RNA polymerase III promoter IPR007087; IPR015880; IPR013087; Zinc finger protein 143 (SPH-binding factor) (Selenocysteine tRNA gene transcription-activating factor) (hStaf) ZNF143 SBF STAF Homo sapiens (Human) TR32632_c0_g1_i7 Q01713 KLF9_RAT 1.00E-18 GO:0003677; GO:1901653; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cellular response to peptide; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Krueppel-like factor 9 (Basic transcription element-binding protein 1) (BTE-binding protein 1) (GC-box-binding protein 1) (Transcription factor BTEB1) Klf9 Bteb Bteb1 Rattus norvegicus (Rat) TR32633_c0_g1_i1 Q8BRG8 TM209_MOUSE 3.00E-122 GO:0016021 integral to membrane IPR019176; Transmembrane protein 209 Tmem209 Mus musculus (Mouse) TR32633_c0_g1_i2 Q8BRG8 TM209_MOUSE 9.00E-123 GO:0016021 integral to membrane IPR019176; Transmembrane protein 209 Tmem209 Mus musculus (Mouse) TR32635_c0_g1_i1 P0C7P0 CISD3_HUMAN 3.00E-13 GO:0051537; GO:0046872; GO:0005739 "2 iron, 2 sulfur cluster binding; metal ion binding; mitochondrion" IPR018967; IPR006622; "CDGSH iron-sulfur domain-containing protein 3, mitochondrial (MitoNEET-related protein 2) (Miner2)" CISD3 Homo sapiens (Human) TR32636_c1_g2_i3 Q9D8B1 AIG1_MOUSE 1.00E-52 GO:0016021 integral to membrane IPR006838; Androgen-induced gene 1 protein (AIG-1) Aig1 Mus musculus (Mouse) TR32640_c2_g1_i1 Q9BVR0 HRC23_HUMAN 2.00E-08 GO:0046872; GO:0004842 metal ion binding; ubiquitin-protein ligase activity IPR010606; Putative HERC2-like protein 3 HERC2P3 Homo sapiens (Human) TR32641_c1_g2_i1 A2BFC9 YI011_DANRE 9.00E-22 Uncharacterized protein FLJ46082 homolog si:ch211-215c18.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR32642_c0_g2_i3 P78314 3BP2_HUMAN 2.00E-07 GO:0005070; GO:0005543; GO:0007165 Q9UJU6; Q96B97; Q9H2K2; P15498; P52735 SH3/SH2 adaptor activity; phospholipid binding; signal transduction IPR011993; IPR001849; IPR000980; SH3 domain-binding protein 2 (3BP-2) SH3BP2 3BP2 RES4-23 Homo sapiens (Human) TR32643_c1_g1_i1 Q13310 PABP4_HUMAN 2.00E-16 GO:0006401; GO:0006396; GO:0007596; GO:0010494; GO:0000166; GO:0005634; GO:0008143; GO:0008266; GO:0006412 Q8WV24 RNA catabolic process; RNA processing; blood coagulation; cytoplasmic stress granule; nucleotide binding; nucleus; poly(A) RNA binding; poly(U) RNA binding; translation IPR012677; IPR006515; IPR002004; IPR000504; Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) TR32643_c2_g1_i5 Q7ZYB4 PAIP1_XENLA 1.00E-10 GO:0003723; GO:0005737; GO:0008494 RNA binding; cytoplasm; translation activator activity IPR016024; IPR016021; IPR003890; Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Paip1 protein) (Poly(A)-binding protein-interacting protein 1) (XlPaip1) paip1 Xenopus laevis (African clawed frog) TR32643_c2_g1_i6 Q9H074 PAIP1_HUMAN 5.00E-11 GO:0003723; GO:0005829; GO:0048255; GO:0000289; GO:0008494; GO:0006413 P11940 RNA binding; cytosol; mRNA stabilization; nuclear-transcribed mRNA poly(A) tail shortening; translation activator activity; translational initiation IPR016024; IPR009818; IPR016021; IPR003890; Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1) PAIP1 Homo sapiens (Human) TR32645_c1_g2_i1 Q5ZMD4 TRI59_CHICK 2.00E-15 GO:0016021; GO:0005622; GO:0008270 integral to membrane; intracellular; zinc ion binding IPR000315; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 59 TRIM59 RCJMB04_2h17 Gallus gallus (Chicken) TR32647_c0_g1_i1 A7Y2W8 SC6A9_XENLA 7.00E-136 GO:0005887; GO:0005328; GO:0005283 integral to plasma membrane; neurotransmitter:sodium symporter activity; sodium:amino acid symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9) slc6a9 glyt1 Xenopus laevis (African clawed frog) TR32647_c0_g1_i2 P31651 S6A12_MOUSE 4.00E-73 GO:0005332; GO:0005887; GO:0005328 gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR002983; Sodium- and chloride-dependent betaine transporter (Na(+)/Cl(-) betaine/GABA transporter) (Sodium- and chloride-dependent GABA transporter 2) (GAT-2) (Solute carrier family 6 member 12) Slc6a12 Gabt2 Gat-2 Gat2 Mus musculus (Mouse) TR3265_c0_g2_i1 Q99572 P2RX7_HUMAN 6.00E-08 GO:0005524; GO:0043132; GO:0043029; GO:0042098; GO:0000187; GO:0097190; GO:0032059; GO:0032060; GO:0000902; GO:0006884; GO:0005911; GO:0031668; GO:0046513; GO:0032963; GO:0005507; GO:0019835; GO:0005737; GO:0050830; GO:0009897; GO:0004931; GO:0048873; GO:0006954; GO:0045087; GO:0005639; GO:0005887; GO:0001530; GO:0000287; GO:0006900; GO:0051899; GO:0006509; GO:0045121; GO:0007005; GO:0044254; GO:0043409; GO:0045779; GO:0031594; GO:0043025; GO:0035872; GO:0001845; GO:0006649; GO:0045332; GO:0007009; GO:0046931; GO:0001916; GO:0043065; GO:0030501; GO:0010524; GO:0045919; GO:0051495; GO:0014054; GO:0014049; GO:0050717; GO:0050718; GO:0032755; GO:0051901; GO:0032308; GO:0043234; GO:0042803; GO:0051259; GO:0006468; GO:0016485; GO:0001614; GO:0072593; GO:0005102; GO:0019228; GO:0051709; GO:0002028; GO:0051209; GO:0033198; GO:0051592; GO:0042493; GO:0051602; GO:0034405; GO:0032496; GO:0009612; GO:0010043; GO:0019233; GO:0048705; GO:0016079; GO:0043195; GO:0008270 P00519; P62993; P16333 "ATP binding; NAD transport; T cell homeostasis; T cell proliferation; activation of MAPK activity; apoptotic signaling pathway; bleb; bleb assembly; cell morphogenesis; cell volume homeostasis; cell-cell junction; cellular response to extracellular stimulus; ceramide biosynthetic process; collagen metabolic process; copper ion binding; cytolysis; cytoplasm; defense response to Gram-positive bacterium; external side of plasma membrane; extracellular ATP-gated cation channel activity; homeostasis of number of cells within a tissue; inflammatory response; innate immune response; integral to nuclear inner membrane; integral to plasma membrane; lipopolysaccharide binding; magnesium ion binding; membrane budding; membrane depolarization; membrane protein ectodomain proteolysis; membrane raft; mitochondrion organization; multicellular organismal protein catabolic process; negative regulation of MAPK cascade; negative regulation of bone resorption; neuromuscular junction; neuronal cell body; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; phagolysosome assembly; phospholipid transfer to membrane; phospholipid translocation; plasma membrane organization; pore complex assembly; positive regulation of T cell mediated cytotoxicity; positive regulation of apoptotic process; positive regulation of bone mineralization; positive regulation of calcium ion transport into cytosol; positive regulation of cytolysis; positive regulation of cytoskeleton organization; positive regulation of gamma-aminobutyric acid secretion; positive regulation of glutamate secretion; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 production; positive regulation of mitochondrial depolarization; positive regulation of prostaglandin secretion; protein complex; protein homodimerization activity; protein oligomerization; protein phosphorylation; protein processing; purinergic nucleotide receptor activity; reactive oxygen species metabolic process; receptor binding; regulation of action potential in neuron; regulation of killing of cells of other organism; regulation of sodium ion transport; release of sequestered calcium ion into cytosol; response to ATP; response to calcium ion; response to drug; response to electrical stimulus; response to fluid shear stress; response to lipopolysaccharide; response to mechanical stimulus; response to zinc ion; sensory perception of pain; skeletal system morphogenesis; synaptic vesicle exocytosis; terminal bouton; zinc ion binding" IPR003050; IPR027309; IPR001429; P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2RX7 Homo sapiens (Human) TR32652_c1_g1_i1 B1WAX6 TIGAR_XENTR 1.00E-38 GO:0004331 "fructose-2,6-bisphosphate 2-phosphatase activity" IPR013078; IPR001345; "Fructose-2,6-bisphosphatase TIGAR (EC 3.1.3.46) (TP53-induced glycolysis and apoptosis regulator)" tigar Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR32652_c1_g1_i2 B1WAX6 TIGAR_XENTR 1.00E-38 GO:0004331 "fructose-2,6-bisphosphate 2-phosphatase activity" IPR013078; IPR001345; "Fructose-2,6-bisphosphatase TIGAR (EC 3.1.3.46) (TP53-induced glycolysis and apoptosis regulator)" tigar Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR32653_c1_g1_i1 C3K732 TPMT_PSEFS 1.00E-15 GO:0005737; GO:0010038; GO:0008119 cytoplasm; response to metal ion; thiopurine S-methyltransferase activity IPR022474; IPR025835; IPR008854; Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) tpm PFLU_1728 Pseudomonas fluorescens (strain SBW25) TR32653_c1_g1_i3 Q504A5 TPMT_DANRE 9.00E-21 GO:0005737; GO:0008119 cytoplasm; thiopurine S-methyltransferase activity IPR025835; IPR008854; Probable thiopurine S-methyltransferase (Thiopurine methyltransferase) (EC 2.1.1.67) tpmt zgc:109981 Danio rerio (Zebrafish) (Brachydanio rerio) TR32653_c1_g2_i1 A1S2Z7 TPMT_SHEAM 1.00E-09 GO:0005737; GO:0010038; GO:0008119 cytoplasm; response to metal ion; thiopurine S-methyltransferase activity IPR022474; IPR025835; IPR008854; Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) tpm Sama_0543 Shewanella amazonensis (strain ATCC BAA-1098 / SB2B) TR32655_c0_g1_i1 Q6NUB2 CW15A_XENLA 5.00E-66 GO:0003723; GO:0000398; GO:0005634; GO:0005681 "RNA binding; mRNA splicing, via spliceosome; nucleus; spliceosomal complex" IPR006973; Protein CWC15 homolog A cwc15-a Xenopus laevis (African clawed frog) TR32656_c0_g1_i1 Q9H892 TTC12_HUMAN 2.00E-104 IPR011989; IPR016024; IPR013026; IPR011990; IPR013105; IPR019734; Tetratricopeptide repeat protein 12 (TPR repeat protein 12) TTC12 Homo sapiens (Human) TR32656_c0_g1_i2 Q9H892 TTC12_HUMAN 2.00E-104 IPR011989; IPR016024; IPR013026; IPR011990; IPR013105; IPR019734; Tetratricopeptide repeat protein 12 (TPR repeat protein 12) TTC12 Homo sapiens (Human) TR32657_c0_g1_i1 P04988 CYSP1_DICDI 1.00E-53 GO:0008234; GO:0006972; GO:0005764; GO:0006508 cysteine-type peptidase activity; hyperosmotic response; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cysteine proteinase 1 (EC 3.4.22.-) cprA CP1 DDB_G0290957 Dictyostelium discoideum (Slime mold) TR32657_c0_g1_i2 P43295 A494_ARATH 5.00E-54 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Probable cysteine proteinase A494 (EC 3.4.22.-) At2g21430 F3K23.19 Arabidopsis thaliana (Mouse-ear cress) TR32659_c0_g2_i1 Q9BZP6 CHIA_HUMAN 1.00E-88 GO:0006915; GO:0030246; GO:0006037; GO:0008061; GO:0006032; GO:0004568; GO:0005737; GO:0007586; GO:0005615; GO:0006955; GO:0003796; GO:0000272; GO:0090197; GO:0002532; GO:0001101; GO:0009620 apoptotic process; carbohydrate binding; cell wall chitin metabolic process; chitin binding; chitin catabolic process; chitinase activity; cytoplasm; digestion; extracellular space; immune response; lysozyme activity; polysaccharide catabolic process; positive regulation of chemokine secretion; production of molecular mediator involved in inflammatory response; response to acid; response to fungus IPR002557; IPR011583; IPR001223; IPR001579; IPR013781; IPR017853; Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Lung-specific protein TSA1902) CHIA Homo sapiens (Human) TR3266_c0_g1_i1 Q8IQ56 TMM11_DROME 6.00E-12 GO:0031305; GO:0005743; GO:0007005 integral to mitochondrial inner membrane; mitochondrial inner membrane; mitochondrion organization IPR026120; "Transmembrane protein 11 homolog, mitochondrial (Protein PMI)" Pmi CG33718 Drosophila melanogaster (Fruit fly) TR32663_c1_g1_i1 Q24799 MYPH_ECHGR 1.00E-41 IPR000557; IPR001715; IPR003096; Myophilin Echinococcus granulosus TR32663_c1_g1_i2 P14318 MP20_DROME 2.00E-28 GO:0003779; GO:0007155; GO:0007520; GO:0008360; GO:1901739 actin binding; cell adhesion; myoblast fusion; regulation of cell shape; regulation of myoblast fusion IPR000557; IPR001715; IPR003096; Muscle-specific protein 20 Mp20 Tpn CG4696 Drosophila melanogaster (Fruit fly) TR32664_c0_g1_i1 Q5NVE2 SRFB1_PONAB 2.00E-15 GO:0048471; GO:0006355; GO:0006351 "perinuclear region of cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR015158; Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) SRFBP1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR32665_c2_g1_i1 B6CZ61 LRC51_RAT 4.00E-48 GO:0005737 cytoplasm IPR001611; Leucine-rich repeat-containing protein 51 (Protein LRTOMT1) Lrrc51 Lrtomt1 Rattus norvegicus (Rat) TR32666_c2_g1_i1 A2A791 ZMYM4_MOUSE 5.00E-47 GO:0007010; GO:0022604; GO:0008270 cytoskeleton organization; regulation of cell morphogenesis; zinc ion binding IPR021893; IPR011017; IPR010507; Zinc finger MYM-type protein 4 (Zinc finger protein 262) Zmym4 Kiaa0425 Zfp262 Znf262 Mus musculus (Mouse) TR32666_c2_g1_i2 O95789 ZMYM6_HUMAN 8.00E-28 GO:0003677; GO:0007010; GO:0007275; GO:0005634; GO:0022604; GO:0008270 DNA binding; cytoskeleton organization; multicellular organismal development; nucleus; regulation of cell morphogenesis; zinc ion binding IPR025398; IPR012337; IPR011017; IPR010507; Zinc finger MYM-type protein 6 (Transposon-derived Buster2 transposase-like protein) (Zinc finger protein 258) ZMYM6 Buster2 KIAA1353 ZNF258 Homo sapiens (Human) TR32666_c3_g1_i1 Q14202 ZMYM3_HUMAN 1.00E-93 GO:0003677; GO:0007010; GO:0007275; GO:0005634; GO:0022604; GO:0008270 DNA binding; cytoskeleton organization; multicellular organismal development; nucleus; regulation of cell morphogenesis; zinc ion binding IPR021893; IPR011017; IPR010507; Zinc finger MYM-type protein 3 (Zinc finger protein 261) ZMYM3 DXS6673E KIAA0385 ZNF261 Homo sapiens (Human) TR32667_c0_g2_i1 P55039 DRG2_HUMAN 0 GO:0005525; GO:0005737; GO:0005739; GO:0007165 GTP binding; cytoplasm; mitochondrion; signal transduction IPR006074; IPR006073; IPR027417; IPR005225; IPR004095; IPR012676; Developmentally-regulated GTP-binding protein 2 (DRG-2) DRG2 Homo sapiens (Human) TR32669_c0_g1_i1 Q70CQ2 UBP34_HUMAN 3.00E-174 GO:0016055; GO:0004197; GO:0090263; GO:0071108; GO:0004221; GO:0006511; GO:0004843 Wnt receptor signaling pathway; cysteine-type endopeptidase activity; positive regulation of canonical Wnt receptor signaling pathway; protein K48-linked deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR016024; IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) USP34 KIAA0570 KIAA0729 Homo sapiens (Human) TR32669_c3_g1_i1 Q70CQ2 UBP34_HUMAN 1.00E-82 GO:0016055; GO:0004197; GO:0090263; GO:0071108; GO:0004221; GO:0006511; GO:0004843 Wnt receptor signaling pathway; cysteine-type endopeptidase activity; positive regulation of canonical Wnt receptor signaling pathway; protein K48-linked deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR016024; IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) USP34 KIAA0570 KIAA0729 Homo sapiens (Human) TR32670_c0_g1_i1 O95847 UCP4_HUMAN 4.00E-120 GO:0045177; GO:0035356; GO:0006091; GO:0048839; GO:0016021; GO:0005743; GO:0043066; GO:0070997; GO:0043025; GO:0008284; GO:0051562; GO:0006810 apical part of cell; cellular triglyceride homeostasis; generation of precursor metabolites and energy; inner ear development; integral to membrane; mitochondrial inner membrane; negative regulation of apoptotic process; neuron death; neuronal cell body; positive regulation of cell proliferation; reduction of mitochondrial calcium ion concentration; transport IPR018108; IPR023395; Mitochondrial uncoupling protein 4 (UCP 4) (Solute carrier family 25 member 27) SLC25A27 UCP4 UNQ772/PRO1566 Homo sapiens (Human) TR32672_c0_g1_i1 P38873 KOG1_YEAST 1.00E-68 GO:0031929; GO:0031931; GO:0009267; GO:0000329; GO:0005886; GO:0001558; GO:0043130 P41318; P35169 TOR signaling cascade; TORC1 complex; cellular response to starvation; fungal-type vacuole membrane; plasma membrane; regulation of cell growth; ubiquitin binding IPR011989; IPR016024; IPR000357; IPR004083; IPR015943; IPR001680; IPR019775; IPR017986; Target of rapamycin complex 1 subunit KOG1 (TORC1 subunit KOG1) (Kontroller of growth protein 1) (Local anesthetic-sensitive protein 24) KOG1 LAS24 YHR186C H9998.14 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR32672_c0_g2_i1 A8NEG8 LIS1_COPC7 2.00E-08 GO:0051301; GO:0006928; GO:0005737; GO:0000132; GO:0005874; GO:0005875; GO:0007067; GO:0000922; GO:0006810 cell division; cellular component movement; cytoplasm; establishment of mitotic spindle orientation; microtubule; microtubule associated complex; mitosis; spindle pole; transport IPR017252; IPR020472; IPR006594; IPR015943; IPR001680; IPR019775; IPR017986; Nuclear distribution protein PAC1 (Lissencephaly-1 homolog) (LIS-1) (nudF homolog) PAC1 LIS1 CC1G_01084 Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata) TR32672_c0_g2_i4 Q8K4Q0 RPTOR_MOUSE 0 GO:0031929; GO:0031931; GO:0016049; GO:0071230; GO:0005764; GO:0032008 Q9JLN9 TOR signaling cascade; TORC1 complex; cell growth; cellular response to amino acid stimulus; lysosome; positive regulation of TOR signaling cascade IPR011989; IPR016024; IPR004083; IPR027466; IPR015943; IPR001680; IPR017986; Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) Rptor Raptor Mus musculus (Mouse) TR32672_c0_g2_i8 P38328 ARPC1_YEAST 9.00E-06 GO:0005885; GO:0030479; GO:0045010; GO:0043130 Q05933; P33204; P53731; P32381; P47117; Q12446; Q04439 Arp2/3 protein complex; actin cortical patch; actin nucleation; ubiquitin binding IPR017383; IPR015943; IPR001680; IPR017986; Actin-related protein 2/3 complex subunit 1 (Arp2/3 complex 41 kDa subunit) (p41-ARC) ARC40 YBR234C YBR1532 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR32672_c0_g2_i9 Q8K4Q0 RPTOR_MOUSE 0 GO:0031929; GO:0031931; GO:0016049; GO:0071230; GO:0005764; GO:0032008 Q9JLN9 TOR signaling cascade; TORC1 complex; cell growth; cellular response to amino acid stimulus; lysosome; positive regulation of TOR signaling cascade IPR011989; IPR016024; IPR004083; IPR027466; IPR015943; IPR001680; IPR017986; Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) Rptor Raptor Mus musculus (Mouse) TR32673_c1_g1_i1 O55739 127L_IIV6 1.00E-09 GO:0003824; GO:0008152 catalytic activity; metabolic process IPR015069; IPR009097; Uncharacterized protein 127L IIV6-127L Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) TR32676_c10_g1_i1 O15442 MPPD1_HUMAN 5.00E-91 GO:0016787 hydrolase activity IPR024201; IPR004843; Metallophosphoesterase domain-containing protein 1 (EC 3.1.-.-) (Adult brain protein 239) (239AB) MPPED1 C22orf1 FAM1A Homo sapiens (Human) TR32676_c10_g1_i3 Q91ZG2 MPPD1_MOUSE 1.00E-91 GO:0016787 hydrolase activity IPR024201; IPR004843; Metallophosphoesterase domain-containing protein 1 (EC 3.1.-.-) Mpped1 D15Bwg0669e Mus musculus (Mouse) TR32677_c1_g1_i2 Q6INH1 RN157_XENLA 3.00E-134 GO:0008270 zinc ion binding IPR001841; IPR013083; RING finger protein 157 rnf157 Xenopus laevis (African clawed frog) TR32680_c2_g1_i1 Q9VZZ9 DOS_DROME 1.00E-07 GO:0005070; GO:0008595; GO:0019730; GO:0005737; GO:0005543; GO:0042461; GO:0005886; GO:0046578; GO:0045500; GO:0008293; GO:0035220 "SH3/SH2 adaptor activity; anterior/posterior axis specification, embryo; antimicrobial humoral response; cytoplasm; phospholipid binding; photoreceptor cell development; plasma membrane; regulation of Ras protein signal transduction; sevenless signaling pathway; torso signaling pathway; wing disc development" IPR011993; IPR001849; Protein daughter of sevenless dos CG1044 Drosophila melanogaster (Fruit fly) TR32681_c4_g4_i2 Q5RDX4 ATAD2_PONAB 1.00E-78 GO:0005524; GO:0006200; GO:0016887; GO:0005634; GO:0006355; GO:0006351 "ATP binding; ATP catabolic process; ATPase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003593; IPR011989; IPR003959; IPR003960; IPR001487; IPR027417; ATPase family AAA domain-containing protein 2 (EC 3.6.1.3) ATAD2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR32681_c5_g1_i1 Q9ULI0 ATD2B_HUMAN 5.00E-18 GO:0005524; GO:0070577; GO:0017111 ATP binding; histone acetyl-lysine binding; nucleoside-triphosphatase activity IPR003593; IPR003959; IPR003960; IPR001487; IPR018359; IPR027417; ATPase family AAA domain-containing protein 2B ATAD2B KIAA1240 Homo sapiens (Human) TR32684_c2_g1_i2 Q5D0K2 CCKAR_CANFA 7.00E-07 GO:0007409; GO:0004951; GO:0038188; GO:0030900; GO:0016021; GO:0001764; GO:0005886 axonogenesis; cholecystokinin receptor activity; cholecystokinin signaling pathway; forebrain development; integral to membrane; neuron migration; plasma membrane IPR009126; IPR000596; IPR015276; IPR000276; IPR017452; Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR Canis familiaris (Dog) (Canis lupus familiaris) TR32684_c2_g1_i7 P0C7U4 C3AR_DANRE 5.00E-06 GO:0004982; GO:0006935; GO:0016021; GO:0005886 N-formyl peptide receptor activity; chemotaxis; integral to membrane; plasma membrane IPR000826; IPR000276; IPR017452; C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R) c3ar1 Danio rerio (Zebrafish) (Brachydanio rerio) TR32684_c2_g1_i8 Q5D0K2 CCKAR_CANFA 3.00E-07 GO:0007409; GO:0004951; GO:0038188; GO:0030900; GO:0016021; GO:0001764; GO:0005886 axonogenesis; cholecystokinin receptor activity; cholecystokinin signaling pathway; forebrain development; integral to membrane; neuron migration; plasma membrane IPR009126; IPR000596; IPR015276; IPR000276; IPR017452; Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR Canis familiaris (Dog) (Canis lupus familiaris) TR32686_c11_g1_i1 O09158 CP3AP_MOUSE 9.00E-25 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR008072; IPR002402; Cytochrome P450 3A25 (EC 1.14.14.1) (CYPIIIA25) Cyp3a25 Mus musculus (Mouse) TR32686_c2_g2_i1 P11707 CP3A6_RABIT 1.00E-33 GO:0070330; GO:0005789; GO:0020037; GO:0005506; GO:0004497 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity IPR001128; IPR017972; IPR008072; IPR002402; Cytochrome P450 3A6 (EC 1.14.14.1) (CYPIIIA6) (Cytochrome P450-3C) CYP3A6 Oryctolagus cuniculus (Rabbit) TR32686_c5_g1_i1 P79152 CP3AJ_CAPAE 2.00E-08 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 3A19 (EC 1.14.14.1) (CYPIIIA19) (Fragment) CYP3A19 Capra aegagrus (Wild goat) TR32686_c9_g1_i1 P46792 RS22_AGABI 6.00E-30 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000630; 40S ribosomal protein S22 (Ribosomal protein S15a) rps22 rps15A Agaricus bisporus (White button mushroom) TR32686_c9_g2_i2 Q6XIM8 RS15A_DROYA 3.00E-36 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000630; 40S ribosomal protein S15a RpS15Aa GE16163 Drosophila yakuba (Fruit fly) TR32687_c0_g1_i1 Q56254 RPOM_THECE 4.00E-10 GO:0003677; GO:0003899; GO:0006355; GO:0003700; GO:0006351; GO:0008270 "DNA binding; DNA-directed RNA polymerase activity; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR019761; IPR001529; IPR012164; IPR006288; IPR001222; DNA-directed RNA polymerase subunit M (EC 2.7.7.6) rpoM Thermococcus celer TR32687_c0_g1_i2 Q04307 RPC10_YEAST 2.00E-17 GO:0003677; GO:0005666; GO:0003899; GO:0042797; GO:0006386; GO:0008270 DNA binding; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase activity; tRNA transcription from RNA polymerase III promoter; termination of RNA polymerase III transcription; zinc ion binding IPR019761; IPR001529; IPR012164; IPR001222; DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) (DNA-directed RNA polymerases III 12.5 kDa polypeptide) (RNA polymerase III subunit C11) RPC11 YDR045C YD9609.01C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR32687_c0_g1_i4 Q9Y2Y1 RPC10_HUMAN 2.00E-39 GO:0003677; GO:0005666; GO:0003899; GO:0005829; GO:0051607; GO:0045087; GO:0032481; GO:0006386; GO:0006385; GO:0008270 DNA binding; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase activity; cytosol; defense response to virus; innate immune response; positive regulation of type I interferon production; termination of RNA polymerase III transcription; transcription elongation from RNA polymerase III promoter; zinc ion binding IPR019761; IPR001529; IPR012164; IPR001222; DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) (DNA-directed RNA polymerase III subunit K) (RNA polymerase III 12.5 kDa subunit) (RPC12.5) (RNA polymerase III subunit C11) (HsC11p) (RPC11) (hRPC11) POLR3K RPC11 My010 Homo sapiens (Human) TR32688_c0_g1_i1 Q2HJD5 ECHD1_BOVIN 2.00E-61 GO:0016831; GO:0005829; GO:0004492 carboxy-lyase activity; cytosol; methylmalonyl-CoA decarboxylase activity IPR001753; IPR018376; Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) (MMCD) (EC 4.1.1.41) ECHDC1 Bos taurus (Bovine) TR32690_c2_g2_i2 Q9ESN4 C1QL3_MOUSE 5.00E-07 GO:0005581; GO:0005576; GO:0050807 collagen; extracellular region; regulation of synapse organization IPR001073; IPR008160; IPR008983; Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13) (CTRP13) (Gliacolin) C1ql3 C1ql Ctrp13 Mus musculus (Mouse) TR32695_c0_g1_i1 Q5R686 CLIP3_PONAB 2.00E-128 GO:0005795; GO:0072321; GO:0031901; GO:0045444; GO:0035594; GO:0044091; GO:0045121; GO:0008017; GO:0031115; GO:0018230; GO:0005886; GO:0043065; GO:0045807; GO:0090004; GO:0010828; GO:0001934; GO:0055038; GO:0032588 Golgi stack; chaperone-mediated protein transport; early endosome membrane; fat cell differentiation; ganglioside binding; membrane biogenesis; membrane raft; microtubule binding; negative regulation of microtubule polymerization; peptidyl-L-cysteine S-palmitoylation; plasma membrane; positive regulation of apoptotic process; positive regulation of endocytosis; positive regulation of establishment of protein localization to plasma membrane; positive regulation of glucose transport; positive regulation of protein phosphorylation; recycling endosome membrane; trans-Golgi network membrane IPR002110; IPR020683; IPR000938; CAP-Gly domain-containing linker protein 3 (Cytoplasmic linker protein 170-related 59 kDa protein) (CLIP-170-related 59 kDa protein) (CLIPR-59) CLIP3 CLIPR59 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR32696_c0_g1_i1 O78518 ILVB_GUITH 8.00E-34 GO:0003984; GO:0009507; GO:0050660; GO:0009097; GO:0000287; GO:0030976; GO:0009099 acetolactate synthase activity; chloroplast; flavin adenine dinucleotide binding; isoleucine biosynthetic process; magnesium ion binding; thiamine pyrophosphate binding; valine biosynthetic process IPR012846; IPR012000; IPR012001; IPR000399; IPR011766; Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4. Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4. Acetolactate synthase large subunit (AHAS) (EC 2.2.1.6) (Acetohydroxy-acid synthase large subunit) (ALS) ilvB Guillardia theta (Cryptomonas phi) TR32696_c0_g1_i2 Q8CHM7 HACL1_RAT 0 GO:0016830; GO:0001561; GO:0000287; GO:0005777; GO:0051259; GO:0030976 carbon-carbon lyase activity; fatty acid alpha-oxidation; magnesium ion binding; peroxisome; protein oligomerization; thiamine pyrophosphate binding IPR012000; IPR012001; IPR011766; Lipid metabolism; fatty acid metabolism. 2-hydroxyacyl-CoA lyase 1 (EC 4.1.-.-) (2-hydroxyphytanoyl-CoA lyase) (2-HPCL) (Phytanoyl-CoA 2-hydroxylase 2) Hacl1 2hpcl Hpcl2 Phyh2 Rattus norvegicus (Rat) TR32696_c0_g1_i3 Q8CHM7 HACL1_RAT 2.00E-175 GO:0016830; GO:0001561; GO:0000287; GO:0005777; GO:0051259; GO:0030976 carbon-carbon lyase activity; fatty acid alpha-oxidation; magnesium ion binding; peroxisome; protein oligomerization; thiamine pyrophosphate binding IPR012000; IPR012001; IPR011766; Lipid metabolism; fatty acid metabolism. 2-hydroxyacyl-CoA lyase 1 (EC 4.1.-.-) (2-hydroxyphytanoyl-CoA lyase) (2-HPCL) (Phytanoyl-CoA 2-hydroxylase 2) Hacl1 2hpcl Hpcl2 Phyh2 Rattus norvegicus (Rat) TR32697_c0_g1_i1 Q8N0N9 ODH_HALDH 2.00E-139 GO:0051287; GO:0005737; GO:0046168; GO:0016616 "NAD binding; cytoplasm; glycerol-3-phosphate catabolic process; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" IPR008927; IPR013328; IPR011128; IPR016040; IPR003421; Opine dehydrogenase (EC 1.5.1.-) tadh Haliotis discus hannai (Japanese abalone) TR32698_c3_g1_i1 D2HWM5 RFWD3_AILME 2.00E-55 GO:0006281; GO:0097371; GO:0016605; GO:0005737; GO:0031571; GO:0005634; GO:0002039; GO:0010212; GO:0004842; GO:0008270 DNA repair; MDM2/MDM4 family protein binding; PML body; cytoplasm; mitotic G1 DNA damage checkpoint; nucleus; p53 binding; response to ionizing radiation; ubiquitin-protein ligase activity; zinc ion binding IPR015943; IPR001680; IPR017986; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RFWD3 (EC 6.3.2.-) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201) RFWD3 RNF201 PANDA_016934 Ailuropoda melanoleuca (Giant panda) TR32698_c3_g1_i2 D2HWM5 RFWD3_AILME 7.00E-57 GO:0006281; GO:0097371; GO:0016605; GO:0005737; GO:0031571; GO:0005634; GO:0002039; GO:0010212; GO:0004842; GO:0008270 DNA repair; MDM2/MDM4 family protein binding; PML body; cytoplasm; mitotic G1 DNA damage checkpoint; nucleus; p53 binding; response to ionizing radiation; ubiquitin-protein ligase activity; zinc ion binding IPR015943; IPR001680; IPR017986; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RFWD3 (EC 6.3.2.-) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201) RFWD3 RNF201 PANDA_016934 Ailuropoda melanoleuca (Giant panda) TR327_c0_g1_i1 O01725 RLA2_BRAFL 3.00E-22 GO:0005840; GO:0003735; GO:0006414 ribosome; structural constituent of ribosome; translational elongation IPR001813; IPR027534; 60S acidic ribosomal protein P2 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR32701_c0_g1_i3 Q7YQK9 TSN7_PONPY 3.00E-18 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-7 (Tspan-7) (Transmembrane 4 superfamily member 2) (CD antigen CD231) TSPAN7 TM4SF2 Pongo pygmaeus (Bornean orangutan) TR32701_c0_g1_i4 P31053 CD37_RAT 1.00E-08 GO:0042832; GO:0001772; GO:0016021; GO:0008285; GO:0030886; GO:0002639; GO:0050688; GO:0002920 defense response to protozoan; immunological synapse; integral to membrane; negative regulation of cell proliferation; negative regulation of myeloid dendritic cell activation; positive regulation of immunoglobulin production; regulation of defense response to virus; regulation of humoral immune response IPR000301; IPR018499; IPR018503; IPR008952; Leukocyte antigen CD37 (CD antigen CD37) Cd37 Rattus norvegicus (Rat) TR32701_c0_g1_i5 Q9D1D1 TSN11_MOUSE 2.00E-16 GO:0016021 integral to membrane IPR000301; IPR018499; IPR008952; Tetraspanin-11 (Tspan-11) Tspan11 Mus musculus (Mouse) TR32701_c0_g1_i7 Q7YQK9 TSN7_PONPY 2.00E-18 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-7 (Tspan-7) (Transmembrane 4 superfamily member 2) (CD antigen CD231) TSPAN7 TM4SF2 Pongo pygmaeus (Bornean orangutan) TR32705_c0_g1_i2 Q96A72 MGN2_HUMAN 1.00E-97 GO:0003723; GO:0008380; GO:0006397; GO:0051028; GO:0005634 RNA binding; RNA splicing; mRNA processing; mRNA transport; nucleus IPR004023; Protein mago nashi homolog 2 MAGOHB MAGOH2 Homo sapiens (Human) TR32707_c0_g1_i1 Q9NPJ8 NXT2_HUMAN 1.00E-43 GO:0005737; GO:0051028; GO:0005634; GO:0015031 cytoplasm; mRNA transport; nucleus; protein transport IPR002075; IPR018222; NTF2-related export protein 2 (Protein p15-2) NXT2 BM-025 DC9 Homo sapiens (Human) TR32708_c0_g1_i1 Q39172 P1_ARATH 5.00E-23 GO:0032440; GO:0005829; GO:0005634; GO:0046686; GO:0006979; GO:0008270 2-alkenal reductase [NAD(P)] activity; cytosol; nucleus; response to cadmium ion; response to oxidative stress; zinc ion binding IPR013149; IPR002085; IPR011032; IPR016040; NADP-dependent alkenal double bond reductase P1 (DBR1) (EC 1.3.1.74) P1 At5g16970 F2K13_120 Arabidopsis thaliana (Mouse-ear cress) TR32708_c0_g1_i2 Q8BGC4 ZADH2_MOUSE 7.00E-118 GO:0005739; GO:0016491; GO:0005777; GO:0008270 mitochondrion; oxidoreductase activity; peroxisome; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; IPR002364; Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-) Zadh2 Mus musculus (Mouse) TR32709_c0_g1_i1 Q8NEZ4 MLL3_HUMAN 5.00E-12 GO:0003677; GO:0042800; GO:0035097; GO:0035556; GO:0006355; GO:0006351; GO:0008270 Q14686 "DNA binding; histone methyltransferase activity (H3-K4 specific); histone methyltransferase complex; intracellular signal transduction; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR017956; IPR003889; IPR003888; IPR009071; IPR000637; IPR003616; IPR002219; IPR001214; IPR001594; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.43) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) KMT2C HALR KIAA1506 MLL3 Homo sapiens (Human) TR32709_c0_g1_i2 Q5VXD3 SAM13_HUMAN 6.00E-24 IPR001660; IPR013761; IPR021129; Sterile alpha motif domain-containing protein 13 (SAM domain-containing protein 13) SAMD13 HSD-42 HSD42 Homo sapiens (Human) TR32709_c0_g1_i3 Q92794 KAT6A_HUMAN 1.00E-21 GO:0003677; GO:0006323; GO:0070776; GO:0016605; GO:0035909; GO:0090398; GO:0003682; GO:0035162; GO:0060325; GO:0003007; GO:0043966; GO:0004402; GO:0030099; GO:0043433; GO:0045892; GO:0005730; GO:0000786; GO:0006334; GO:0045893; GO:0035019; GO:0003713; GO:0008134; GO:0006351; GO:0008270 Q03164; P61964 "DNA binding; DNA packaging; MOZ/MORF histone acetyltransferase complex; PML body; aorta morphogenesis; cellular senescence; chromatin binding; embryonic hemopoiesis; face morphogenesis; heart morphogenesis; histone H3 acetylation; histone acetyltransferase activity; myeloid cell differentiation; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; nucleolus; nucleosome; nucleosome assembly; positive regulation of transcription, DNA-dependent; somatic stem cell maintenance; transcription coactivator activity; transcription factor binding; transcription, DNA-dependent; zinc ion binding" IPR016181; IPR005818; IPR002717; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; "Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220)" KAT6A MOZ MYST3 RUNXBP2 ZNF220 Homo sapiens (Human) TR32711_c1_g1_i2 P38040 GBG1_DROME 9.00E-14 GO:0007186; GO:0003924; GO:0007015; GO:0045176; GO:0055059; GO:0061343; GO:0007391; GO:0035050; GO:0003015; GO:0005834; GO:0007637; GO:0008360; GO:0004871 G-protein coupled receptor signaling pathway; GTPase activity; actin filament organization; apical protein localization; asymmetric neuroblast division; cell adhesion involved in heart morphogenesis; dorsal closure; embryonic heart tube development; heart process; heterotrimeric G-protein complex; proboscis extension reflex; regulation of cell shape; signal transducer activity IPR015898; IPR001770; Guanine nucleotide-binding protein subunit gamma-1 Ggamma1 G1 CG8261 Drosophila melanogaster (Fruit fly) TR32713_c0_g1_i1 A4QN56 NAGT1_DANRE 3.00E-08 GO:0016324; GO:0008643; GO:0016021; GO:0006814; GO:0015293 apical plasma membrane; carbohydrate transport; integral to membrane; sodium ion transport; symporter activity IPR011701; IPR016196; Sodium-dependent glucose transporter 1 naglt1 zgc:162161 Danio rerio (Zebrafish) (Brachydanio rerio) TR32713_c0_g1_i2 Q569T7 NAGT1_XENLA 4.00E-09 GO:0016324; GO:0008643; GO:0016021; GO:0006814; GO:0015293 apical plasma membrane; carbohydrate transport; integral to membrane; sodium ion transport; symporter activity IPR011701; IPR016196; Sodium-dependent glucose transporter 1 naglt1 Xenopus laevis (African clawed frog) TR32717_c4_g2_i2 Q9H8W5 TRI45_HUMAN 5.00E-07 GO:0060348; GO:0005737; GO:0005634; GO:0008270 bone development; cytoplasm; nucleus; zinc ion binding IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) TR32717_c4_g2_i4 Q1PSW8 LIN41_MOUSE 5.00E-09 GO:0000082; GO:0000932; GO:0008543; GO:0035198; GO:0010586; GO:0035278; GO:0001843; GO:2000637; GO:0051865; GO:2000177; GO:0072089; GO:0004842; GO:0008270 G1/S transition of mitotic cell cycle; cytoplasmic mRNA processing body; fibroblast growth factor receptor signaling pathway; miRNA binding; miRNA metabolic process; negative regulation of translation involved in gene silencing by miRNA; neural tube closure; positive regulation of gene silencing by miRNA; protein autoubiquitination; regulation of neural precursor cell proliferation; stem cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (mLin41) (Tripartite motif-containing protein 71) Trim71 Gm1127 Lin41 Mus musculus (Mouse) TR32718_c4_g1_i1 Q7LGC8 CHST3_HUMAN 3.00E-11 GO:0000139; GO:0043029; GO:0005975; GO:0008459; GO:0030206; GO:0016021; GO:0050698 Golgi membrane; T cell homeostasis; carbohydrate metabolic process; chondroitin 6-sulfotransferase activity; chondroitin sulfate biosynthetic process; integral to membrane; proteoglycan sulfotransferase activity IPR016469; IPR027417; IPR000863; Carbohydrate sulfotransferase 3 (EC 2.8.2.17) (Chondroitin 6-O-sulfotransferase 1) (C6ST-1) (Chondroitin 6-sulfotransferase) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0) (GST-0) CHST3 Homo sapiens (Human) TR32719_c0_g1_i1 Q8NFU5 IPMK_HUMAN 2.00E-07 GO:0005524; GO:0032958; GO:0043647; GO:0000824; GO:0008440; GO:0000823; GO:0001841; GO:0005654 "ATP binding; inositol phosphate biosynthetic process; inositol phosphate metabolic process; inositol tetrakisphosphate 3-kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; inositol-1,4,5-trisphosphate 6-kinase activity; neural tube formation; nucleoplasm" IPR005522; "Inositol polyphosphate multikinase (EC 2.7.1.151) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase)" IPMK IMPK Homo sapiens (Human) TR32719_c0_g1_i2 Q8BWD2 IP6K3_MOUSE 2.00E-19 GO:0005524; GO:0005737; GO:0052723; GO:0052724; GO:0000832; GO:0000831; GO:0032958; GO:0008440; GO:0005634; GO:0046488; GO:0006468 "ATP binding; cytoplasm; inositol hexakisphosphate 1-kinase activity; inositol hexakisphosphate 3-kinase activity; inositol hexakisphosphate 5-kinase activity; inositol hexakisphosphate 6-kinase activity; inositol phosphate biosynthetic process; inositol-1,4,5-trisphosphate 3-kinase activity; nucleus; phosphatidylinositol metabolic process; protein phosphorylation" IPR005522; Inositol hexakisphosphate kinase 3 (InsP6 kinase 3) (EC 2.7.4.21) (Inositol hexaphosphate kinase 3) Ip6k3 Ihpk3 Mus musculus (Mouse) TR32723_c1_g2_i4 P83425 HIP_MYTED 1.00E-09 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR32724_c3_g1_i1 Q9V7G5 C4AA1_DROME 1.00E-32 GO:0005789; GO:0020037; GO:0005506; GO:0004497; GO:0016705 "endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002403; Probable cytochrome P450 4aa1 (EC 1.14.-.-) (CYPIVAA1) Cyp4aa1 CG8302 Drosophila melanogaster (Fruit fly) TR32724_c4_g1_i2 Q9JMA7 CP341_MOUSE 5.00E-112 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR008072; IPR002402; Cytochrome P450 3A41 (EC 1.14.14.1) Cyp3a41a Cyp3a41; Cyp3a41b Mus musculus (Mouse) TR32726_c0_g1_i4 O88419 B4GT6_RAT 1.00E-64 GO:0032580; GO:0008489; GO:0006688; GO:0016021; GO:0046872; GO:0006486 "Golgi cisterna membrane; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity; glycosphingolipid biosynthetic process; integral to membrane; metal ion binding; protein glycosylation" IPR003859; IPR027791; IPR027995; Protein modification; protein glycosylation. "Beta-1,4-galactosyltransferase 6 (Beta-1,4-GalTase 6) (Beta4Gal-T6) (b4Gal-T6) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6) [Includes: Glucosylceramide beta-1,4-galactosyltransferase (EC 2.4.1.274) (Lactosylceramide synthase) (LacCer synthase) (UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase)]" B4galt6 Rattus norvegicus (Rat) TR32728_c0_g1_i1 Q8BI21 RNF38_MOUSE 1.00E-07 GO:0008270 zinc ion binding IPR001841; IPR013083; RING finger protein 38 Rnf38 Mus musculus (Mouse) TR32728_c0_g1_i2 Q5XIL0 RN167_RAT 6.00E-10 GO:0005737; GO:0012505; GO:0016021; GO:0045786; GO:0000209; GO:0004842; GO:0008270 cytoplasm; endomembrane system; integral to membrane; negative regulation of cell cycle; protein polyubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003137; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF167 (EC 6.3.2.-) (RING finger protein 167) Rnf167 Rattus norvegicus (Rat) TR32729_c3_g1_i1 Q6ZQ03 FNBP4_MOUSE 2.00E-28 GO:0005634 nucleus IPR001202; Formin-binding protein 4 (Formin-binding protein 30) Fnbp4 Fbp30 Kiaa1014 Mus musculus (Mouse) TR32729_c3_g1_i3 Q8N3X1 FNBP4_HUMAN 2.00E-29 GO:0005634 nucleus IPR001202; Formin-binding protein 4 (Formin-binding protein 30) FNBP4 FBP30 KIAA1014 Homo sapiens (Human) TR32729_c4_g1_i6 Q8N3X1 FNBP4_HUMAN 2.00E-06 GO:0005634 nucleus IPR001202; Formin-binding protein 4 (Formin-binding protein 30) FNBP4 FBP30 KIAA1014 Homo sapiens (Human) TR32729_c4_g1_i7 Q6ZQ03 FNBP4_MOUSE 5.00E-08 GO:0005634 nucleus IPR001202; Formin-binding protein 4 (Formin-binding protein 30) Fnbp4 Fbp30 Kiaa1014 Mus musculus (Mouse) TR32733_c0_g1_i1 Q80U56 AVL9_MOUSE 1.00E-98 GO:0016477; GO:0016021; GO:0055037 cell migration; integral to membrane; recycling endosome IPR018307; Late secretory pathway protein AVL9 homolog Avl9 Kiaa0241 Mus musculus (Mouse) TR32733_c0_g3_i3 Q80U56 AVL9_MOUSE 6.00E-19 GO:0016477; GO:0016021; GO:0055037 cell migration; integral to membrane; recycling endosome IPR018307; Late secretory pathway protein AVL9 homolog Avl9 Kiaa0241 Mus musculus (Mouse) TR32734_c1_g1_i1 Q29485 PLMN_ERIEU 1.00E-13 GO:0007596; GO:0005576; GO:0042730; GO:0006508; GO:0004252; GO:0048771 blood coagulation; extracellular region; fibrinolysis; proteolysis; serine-type endopeptidase activity; tissue remodeling IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Erinaceus europaeus (Western European hedgehog) TR32734_c1_g1_i2 P00747 PLMN_HUMAN 2.00E-14 GO:0006915; GO:0044267; GO:0022617; GO:0005615; GO:0031232; GO:0042730; GO:0060716; GO:0071674; GO:0046716; GO:0045445; GO:0008285; GO:2000048; GO:0010812; GO:0051918; GO:0030168; GO:0031093; GO:0002576; GO:0051919; GO:0051603; GO:0004252; GO:0042246; GO:0048771; GO:0060707 Q6V4L1; Q6V4L4; Q6V4L5; Q6V4L9; Q99SU7; P00779 apoptotic process; cellular protein metabolic process; extracellular matrix disassembly; extracellular space; extrinsic to external side of plasma membrane; fibrinolysis; labyrinthine layer blood vessel development; mononuclear cell migration; muscle cell cellular homeostasis; myoblast differentiation; negative regulation of cell proliferation; negative regulation of cell-cell adhesion mediated by cadherin; negative regulation of cell-substrate adhesion; negative regulation of fibrinolysis; platelet activation; platelet alpha granule lumen; platelet degranulation; positive regulation of fibrinolysis; proteolysis involved in cellular protein catabolic process; serine-type endopeptidase activity; tissue regeneration; tissue remodeling; trophoblast giant cell differentiation IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Homo sapiens (Human) TR32734_c2_g2_i7 Q7SIC1 FUCL_ANGAN 2.00E-18 GO:0005509; GO:0007155; GO:0005576; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular region; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin Anguilla anguilla (European freshwater eel) (Muraena anguilla) TR32735_c0_g1_i1 P77296 YBET_ECOLI 7.00E-06 IPR006597; IPR011990; Uncharacterized protein YbeT ybeT b0647 JW0642 Escherichia coli (strain K12) TR32735_c0_g1_i2 P77296 YBET_ECOLI 8.00E-06 IPR006597; IPR011990; Uncharacterized protein YbeT ybeT b0647 JW0642 Escherichia coli (strain K12) TR32740_c0_g1_i1 P15508 SPTB1_MOUSE 2.00E-22 GO:0051015; GO:0051693; GO:0030863; GO:0030097; GO:0005886; GO:0007009; GO:0006779; GO:0008091; GO:0014731; GO:0005200 actin filament binding; actin filament capping; cortical cytoskeleton; hemopoiesis; plasma membrane; plasma membrane organization; porphyrin-containing compound biosynthetic process; spectrin; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR001589; IPR001715; IPR018159; IPR016343; IPR002017; "Spectrin beta chain, erythrocytic (Beta-I spectrin)" Sptb Spnb-1 Spnb1 Sptb1 Mus musculus (Mouse) TR32740_c0_g1_i2 P16546 SPTN1_MOUSE 8.00E-40 GO:0030018; GO:0051693; GO:0005509; GO:0032437; GO:0005916; GO:0016328; GO:0033270; GO:0046982; GO:0030507 Z disc; actin filament capping; calcium ion binding; cuticular plate; fascia adherens; lateral plasma membrane; paranode region of axon; protein heterodimerization activity; spectrin binding IPR011992; IPR014837; IPR018247; IPR002048; IPR001452; IPR018159; IPR013315; IPR002017; "Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain)" Sptan1 Spna2 Spta2 Mus musculus (Mouse) TR32742_c0_g3_i3 Q9D1I6 RM14_MOUSE 1.00E-32 GO:0005739; GO:0005840; GO:0003735; GO:0006412 mitochondrion; ribosome; structural constituent of ribosome; translation IPR023571; IPR000218; "39S ribosomal protein L14, mitochondrial (L14mt) (MRP-L14)" Mrpl14 Mus musculus (Mouse) TR32744_c0_g1_i1 Q3T062 RRP15_BOVIN 1.00E-21 IPR012459; RRP15-like protein (Ribosomal RNA-processing protein 15) RRP15 Bos taurus (Bovine) TR32744_c0_g1_i2 Q7ZV20 RRP15_DANRE 5.00E-23 IPR012459; RRP15-like protein rrp15 zgc:56269 Danio rerio (Zebrafish) (Brachydanio rerio) TR32745_c1_g1_i1 Q9Y7Y3 YGR4_SCHPO 1.00E-15 GO:0003723; GO:0005730; GO:0000166; GO:0042254 RNA binding; nucleolus; nucleotide binding; ribosome biogenesis IPR012677; IPR000504; Uncharacterized RNA-binding protein C365.04c SPBC365.04c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR32746_c5_g1_i3 P10716 CLC4F_RAT 3.00E-11 GO:0030246; GO:0006897; GO:0016021; GO:0004872 carbohydrate binding; endocytosis; integral to membrane; receptor activity IPR001304; IPR016186; IPR018378; IPR016187; C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13) (Kupffer cell receptor) Clec4f Clecsf13 Kclr Rattus norvegicus (Rat) TR32747_c0_g1_i1 O81644 VILI2_ARATH 6.00E-48 GO:0051017; GO:0051693; GO:0005737; GO:0005856 actin filament bundle assembly; actin filament capping; cytoplasm; cytoskeleton IPR007123; IPR007122; IPR003128; Villin-2 VLN2 At2g41740 T11A7.16 Arabidopsis thaliana (Mouse-ear cress) TR32747_c0_g1_i2 Q7JQD3 GELS1_LUMTE 5.00E-122 GO:0003779; GO:0051693; GO:0030043; GO:0030041; GO:0051014; GO:0045010; GO:0005509; GO:0005737; GO:0005856; GO:0007275 actin binding; actin filament capping; actin filament fragmentation; actin filament polymerization; actin filament severing; actin nucleation; calcium ion binding; cytoplasm; cytoskeleton; multicellular organismal development IPR007123; IPR007122; Gelsolin-like protein 1 (Actin-modulator) (EWAM) (EWAM-P1) AM Lumbricus terrestris (Common earthworm) TR32747_c0_g1_i3 Q8MPM1 GELS2_LUMTE 8.00E-121 GO:0051693; GO:0005737; GO:0005856 actin filament capping; cytoplasm; cytoskeleton IPR007123; IPR007122; Gelsolin-like protein 2 (Actin-modulator) (EWAM-P2) gelsolin Lumbricus terrestris (Common earthworm) TR32747_c0_g1_i5 Q24800 SEVE_ECHGR 9.00E-58 GO:0051693 actin filament capping IPR007123; IPR007122; Severin AG8 Echinococcus granulosus TR32747_c0_g1_i6 Q7JQD3 GELS1_LUMTE 3.00E-79 GO:0003779; GO:0051693; GO:0030043; GO:0030041; GO:0051014; GO:0045010; GO:0005509; GO:0005737; GO:0005856; GO:0007275 actin binding; actin filament capping; actin filament fragmentation; actin filament polymerization; actin filament severing; actin nucleation; calcium ion binding; cytoplasm; cytoskeleton; multicellular organismal development IPR007123; IPR007122; Gelsolin-like protein 1 (Actin-modulator) (EWAM) (EWAM-P1) AM Lumbricus terrestris (Common earthworm) TR32752_c2_g1_i1 Q96MM6 HS12B_HUMAN 2.00E-70 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR32752_c2_g1_i2 Q892R0 DNAK_CLOTE 4.00E-08 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK CTC_02031 Clostridium tetani (strain Massachusetts / E88) TR32753_c0_g1_i2 Q7T2A5 EIF3L_DANRE 0 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0006446; GO:0003743; GO:0006413 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; regulation of translational initiation; translation initiation factor activity; translational initiation IPR019382; Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein) eif3l eif3eip eif3s6ip Danio rerio (Zebrafish) (Brachydanio rerio) TR32755_c2_g1_i2 O14804 TAAR5_HUMAN 7.00E-18 GO:0005887; GO:0007268; GO:1990081 integral to plasma membrane; synaptic transmission; trimethylamine receptor activity IPR000276; IPR017452; IPR009132; Trace amine-associated receptor 5 (TaR-5) (Trace amine receptor 5) (hTaar5) (Putative neurotransmitter receptor) TAAR5 PNR Homo sapiens (Human) TR32755_c2_g1_i3 Q923Y8 TAAR1_MOUSE 7.00E-24 GO:0007191; GO:0016021; GO:0005886; GO:0001594 adenylate cyclase-activating dopamine receptor signaling pathway; integral to membrane; plasma membrane; trace-amine receptor activity IPR000276; IPR017452; IPR009133; IPR009132; Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1) Taar1 Ta1 Tar1 Trar1 Mus musculus (Mouse) TR32755_c2_g1_i6 P35346 SSR5_HUMAN 4.00E-08 GO:0007187; GO:0042593; GO:0005887; GO:0008285; GO:0050796; GO:0004994 "G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; glucose homeostasis; integral to plasma membrane; negative regulation of cell proliferation; regulation of insulin secretion; somatostatin receptor activity" IPR000276; IPR017452; IPR000586; IPR001184; Somatostatin receptor type 5 (SS-5-R) (SS5-R) (SS5R) SSTR5 Homo sapiens (Human) TR32755_c2_g1_i7 Q923Y8 TAAR1_MOUSE 6.00E-24 GO:0007191; GO:0016021; GO:0005886; GO:0001594 adenylate cyclase-activating dopamine receptor signaling pathway; integral to membrane; plasma membrane; trace-amine receptor activity IPR000276; IPR017452; IPR009133; IPR009132; Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1) Taar1 Ta1 Tar1 Trar1 Mus musculus (Mouse) TR32755_c2_g1_i8 O14804 TAAR5_HUMAN 7.00E-18 GO:0005887; GO:0007268; GO:1990081 integral to plasma membrane; synaptic transmission; trimethylamine receptor activity IPR000276; IPR017452; IPR009132; Trace amine-associated receptor 5 (TaR-5) (Trace amine receptor 5) (hTaar5) (Putative neurotransmitter receptor) TAAR5 PNR Homo sapiens (Human) TR32756_c0_g1_i1 Q8CI33 C19L1_MOUSE 0 GO:0003824; GO:0008152 catalytic activity; metabolic process IPR006768; IPR006767; IPR011146; CWF19-like protein 1 Cwf19l1 Mus musculus (Mouse) TR32757_c0_g1_i3 O75954 TSN9_HUMAN 1.00E-29 GO:0005887 integral to plasma membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-9 (Tspan-9) (Tetraspan NET-5) TSPAN9 NET5 Homo sapiens (Human) TR32758_c3_g1_i5 P86854 PLCL_MYTGA 6.00E-06 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR32758_c3_g1_i6 P82596 PLC_HALLA 2.00E-07 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR32760_c0_g1_i2 O75223 GGCT_HUMAN 1.00E-16 GO:0005829; GO:0003839; GO:0006750; GO:1901687; GO:0042803; GO:0001836; GO:0006805 cytosol; gamma-glutamylcyclotransferase activity; glutathione biosynthetic process; glutathione derivative biosynthetic process; protein homodimerization activity; release of cytochrome c from mitochondria; xenobiotic metabolic process IPR013024; IPR017939; Gamma-glutamylcyclotransferase (EC 2.3.2.4) (Cytochrome c-releasing factor 21) GGCT C7orf24 CRF21 Homo sapiens (Human) TR32761_c0_g1_i1 Q54C25 GPN1_DICDI 1.00E-16 GO:0005525; GO:0005737; GO:0017111; GO:0007264 GTP binding; cytoplasm; nucleoside-triphosphatase activity; small GTPase mediated signal transduction IPR003593; IPR027417; IPR001806; IPR004130; GPN-loop GTPase 1 homolog (XPA-binding protein 1 homolog) xab1 DDB_G0293220 Dictyostelium discoideum (Slime mold) TR32761_c0_g1_i2 Q6PUR6 GPN2_DANRE 8.00E-135 GO:0005525 GTP binding IPR027417; IPR004130; GPN-loop GTPase 2 (ATP-binding domain 1 family member B) gpn2 atpbd1b zgc:92877 Danio rerio (Zebrafish) (Brachydanio rerio) TR32762_c0_g1_i1 Q8BKE9 IFT74_MOUSE 6.00E-97 GO:0005813; GO:0003682; GO:0016023; GO:0005634; GO:0033630; GO:0045944 centrosome; chromatin binding; cytoplasmic membrane-bounded vesicle; nucleus; positive regulation of cell adhesion mediated by integrin; positive regulation of transcription from RNA polymerase II promoter Intraflagellar transport protein 74 homolog (Capillary morphogenesis gene 1 protein) (CMG-1) (Coiled-coil domain-containing protein 2) Ift74 Ccdc2 Cmg1 Mus musculus (Mouse) TR32762_c0_g2_i2 Q96LB3 IFT74_HUMAN 5.00E-31 GO:0005813; GO:0003682; GO:0005737; GO:0016023; GO:0030992; GO:0031514; GO:0005634; GO:0033630; GO:0045944 centrosome; chromatin binding; cytoplasm; cytoplasmic membrane-bounded vesicle; intraflagellar transport particle B; motile cilium; nucleus; positive regulation of cell adhesion mediated by integrin; positive regulation of transcription from RNA polymerase II promoter Intraflagellar transport protein 74 homolog (Capillary morphogenesis gene 1 protein) (CMG-1) (Coiled-coil domain-containing protein 2) IFT74 CCDC2 CMG1 Homo sapiens (Human) TR32763_c0_g1_i1 C4LK80 BIOWF_CORK4 9.00E-53 GO:0042410; GO:0008710; GO:0005524; GO:0009102; GO:0030170 6-carboxyhexanoate-CoA ligase activity; 8-amino-7-oxononanoate synthase activity; ATP binding; biotin biosynthetic process; pyridoxal phosphate binding IPR004839; IPR005499; IPR015424; IPR015421; IPR015422; Metabolic intermediate metabolism; pimeloyl-CoA biosynthesis; pimeloyl-CoA from pimelate: step 1/1. Cofactor biosynthesis; biotin biosynthesis. Biotin biosynthesis bifunctional protein BioWF [Includes: 6-carboxyhexanoate--CoA ligase (EC 6.2.1.14) (Pimeloyl-CoA synthase); 8-amino-7-oxononanoate synthase (AONS) (EC 2.3.1.47) (7-keto-8-amino-pelargonic acid synthase) (7-KAP synthase) (8-amino-7-ketopelargonate synthase)] bioWF ckrop_1506 Corynebacterium kroppenstedtii (strain DSM 44385 / CCUG 35717) TR32763_c0_g1_i2 O88986 KBL_MOUSE 0 GO:0019518; GO:0009058; GO:0008890; GO:0005739; GO:0005634; GO:0030170 L-threonine catabolic process to glycine; biosynthetic process; glycine C-acetyltransferase activity; mitochondrion; nucleus; pyridoxal phosphate binding IPR011282; IPR001917; IPR004839; IPR015424; IPR015421; IPR015422; Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2. "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (AKB ligase) (EC 2.3.1.29) (Aminoacetone synthase) (Glycine acetyltransferase)" Gcat Kbl Mus musculus (Mouse) TR32765_c3_g1_i2 Q04336 YM54_YEAST 3.00E-14 GO:0003824; GO:0008152 catalytic activity; metabolic process IPR008928; Uncharacterized protein YMR196W YMR196W YM9646.09 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR32765_c5_g1_i2 P53008 CWH41_YEAST 5.00E-06 GO:0005789; GO:0009272; GO:0016021; GO:0004573; GO:0009311; GO:0006487 P53090; Q6Q5K6; P21524 endoplasmic reticulum membrane; fungal-type cell wall biogenesis; integral to membrane; mannosyl-oligosaccharide glucosidase activity; oligosaccharide metabolic process; protein N-linked glycosylation IPR008928; IPR004888; Glycan metabolism; N-glycan degradation. Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I) (Glucosidase I) CWH41 GLS1 YGL027C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR32765_c8_g2_i3 Q04336 YM54_YEAST 6.00E-48 GO:0003824; GO:0008152 catalytic activity; metabolic process IPR008928; Uncharacterized protein YMR196W YMR196W YM9646.09 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR32769_c0_g1_i1 Q58DQ5 RT09_BOVIN 1.00E-83 GO:0005739; GO:0005840; GO:0003735; GO:0006412 mitochondrion; ribosome; structural constituent of ribosome; translation IPR020568; IPR014721; IPR000754; IPR020574; "28S ribosomal protein S9, mitochondrial (MRP-S9) (S9mt)" MRPS9 Bos taurus (Bovine) TR32771_c0_g1_i2 O54753 H17B6_RAT 2.00E-64 GO:0008209; GO:0005789; GO:0004303; GO:0004745; GO:0047035 androgen metabolic process; endoplasmic reticulum membrane; estradiol 17-beta-dehydrogenase activity; retinol dehydrogenase activity; testosterone dehydrogenase (NAD+) activity IPR002198; IPR002347; IPR016040; IPR020904; 17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.239) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) Hsd17b6 Hsd17b9 Rattus norvegicus (Rat) TR32772_c1_g1_i2 O88741 GDAP1_MOUSE 1.00E-26 GO:0031307; GO:0000266; GO:0006626; GO:0032526 integral to mitochondrial outer membrane; mitochondrial fission; protein targeting to mitochondrion; response to retinoic acid IPR010987; IPR004045; IPR012336; Ganglioside-induced differentiation-associated protein 1 (GDAP1) Gdap1 Mus musculus (Mouse) TR32774_c2_g1_i1 P59047 NALP5_HUMAN 6.00E-06 GO:0005524; GO:0045179; GO:0043623; GO:0005829; GO:0007566; GO:0009566; GO:0001701; GO:0005739; GO:0005730; GO:0009887; GO:0043234; GO:0043487; GO:0031647 ATP binding; apical cortex; cellular protein complex assembly; cytosol; embryo implantation; fertilization; in utero embryonic development; mitochondrion; nucleolus; organ morphogenesis; protein complex; regulation of RNA stability; regulation of protein stability IPR004020; IPR011029; IPR007111; IPR027417; "NACHT, LRR and PYD domains-containing protein 5 (Mater protein homolog)" NLRP5 MATER NALP5 Homo sapiens (Human) TR32774_c2_g1_i2 Q4V8D9 LRC34_RAT 5.00E-116 Leucine-rich repeat-containing protein 34 Lrrc34 Rattus norvegicus (Rat) TR32774_c2_g1_i3 Q7RTR2 NLRC3_HUMAN 2.00E-28 GO:0005524; GO:0007249; GO:0042110; GO:0005737; GO:0043124; GO:0032088 ATP binding; I-kappaB kinase/NF-kappaB cascade; T cell activation; cytoplasm; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of NF-kappaB transcription factor activity IPR007111; Protein NLRC3 (CARD15-like protein) (Caterpiller protein 16.2) (CLR16.2) (Nucleotide-binding oligomerization domain protein 3) NLRC3 NOD3 Homo sapiens (Human) TR32774_c2_g1_i4 Q6ZQY2 YV012_HUMAN 4.00E-13 Leucine-rich repeat-containing protein LOC400891 Homo sapiens (Human) TR32774_c2_g1_i5 Q0VAA2 CN16B_HUMAN 9.00E-12 Uncharacterized protein C14orf166B C14orf166B Homo sapiens (Human) TR32775_c7_g3_i1 P51815 ZN75D_HUMAN 4.00E-12 GO:0003677; GO:0005634; GO:0006355; GO:0003700; GO:0006351; GO:0008270 "DNA binding; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein 75D (Zinc finger protein 75) (Zinc finger protein 82) ZNF75D ZNF75 ZNF82 Homo sapiens (Human) TR32775_c7_g3_i2 Q86V71 ZN429_HUMAN 1.00E-10 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 429 ZNF429 Homo sapiens (Human) TR32778_c0_g1_i1 Q6IN84 MRM1_HUMAN 2.00E-34 GO:0003723; GO:0001510; GO:0008173; GO:0006396; GO:0005739 RNA binding; RNA methylation; RNA methyltransferase activity; RNA processing; mitochondrion IPR004441; IPR001537; IPR013123; "rRNA methyltransferase 1, mitochondrial (EC 2.1.1.-) (Mitochondrial large ribosomal RNA ribose methylase)" MRM1 Homo sapiens (Human) TR32778_c0_g1_i2 Q8EAG8 RLMB_SHEON 2.00E-20 GO:0003723; GO:0005737; GO:0070039; GO:0000451 RNA binding; cytoplasm; rRNA (guanosine-2'-O-)-methyltransferase activity; rRNA 2'-O-methylation IPR024915; IPR004441; IPR001537; IPR013123; 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB (EC 2.1.1.185) (23S rRNA (guanosine2251 2'-O)-methyltransferase) (23S rRNA Gm2251 2'-O-methyltransferase) rlmB SO_3934 Shewanella oneidensis (strain MR-1) TR32778_c0_g1_i4 O94631 MRM1_SCHPO 1.00E-31 GO:0003723; GO:0005783; GO:0005739; GO:0008989 RNA binding; endoplasmic reticulum; mitochondrion; rRNA (guanine-N1-)-methyltransferase activity IPR004441; IPR001537; IPR013123; "rRNA methyltransferase, mitochondrial (EC 2.1.1.-) (Mitochondrial large ribosomal RNA ribose methylase)" mrm1 SPBC1347.13c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR32778_c0_g1_i5 O94631 MRM1_SCHPO 7.00E-32 GO:0003723; GO:0005783; GO:0005739; GO:0008989 RNA binding; endoplasmic reticulum; mitochondrion; rRNA (guanine-N1-)-methyltransferase activity IPR004441; IPR001537; IPR013123; "rRNA methyltransferase, mitochondrial (EC 2.1.1.-) (Mitochondrial large ribosomal RNA ribose methylase)" mrm1 SPBC1347.13c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR32778_c0_g1_i7 Q8EAG8 RLMB_SHEON 2.00E-20 GO:0003723; GO:0005737; GO:0070039; GO:0000451 RNA binding; cytoplasm; rRNA (guanosine-2'-O-)-methyltransferase activity; rRNA 2'-O-methylation IPR024915; IPR004441; IPR001537; IPR013123; 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB (EC 2.1.1.185) (23S rRNA (guanosine2251 2'-O)-methyltransferase) (23S rRNA Gm2251 2'-O-methyltransferase) rlmB SO_3934 Shewanella oneidensis (strain MR-1) TR32778_c0_g1_i8 Q6IN84 MRM1_HUMAN 2.00E-34 GO:0003723; GO:0001510; GO:0008173; GO:0006396; GO:0005739 RNA binding; RNA methylation; RNA methyltransferase activity; RNA processing; mitochondrion IPR004441; IPR001537; IPR013123; "rRNA methyltransferase 1, mitochondrial (EC 2.1.1.-) (Mitochondrial large ribosomal RNA ribose methylase)" MRM1 Homo sapiens (Human) TR32779_c3_g2_i1 Q99J08 S14L2_MOUSE 3.00E-104 GO:0005737; GO:0016021; GO:0008289; GO:0005634; GO:0006355; GO:0006351; GO:0005215 "cytoplasm; integral to membrane; lipid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; transporter activity" IPR001071; IPR001251; IPR011074; IPR009038; SEC14-like protein 2 (Alpha-tocopherol-associated protein) (TAP) Sec14l2 Mus musculus (Mouse) TR32784_c0_g2_i1 O17444 VACHT_DROME 1.00E-176 GO:0006855; GO:0015238; GO:0016021; GO:0006836 drug transmembrane transport; drug transmembrane transporter activity; integral to membrane; neurotransmitter transport IPR011701; IPR020846; IPR016196; IPR004734; Vesicular acetylcholine transporter (VAChT) VAChT CG32848 Drosophila melanogaster (Fruit fly) TR32785_c0_g1_i1 Q5SYH2 TM199_MOUSE 1.00E-26 GO:0016021 integral to membrane IPR021013; Transmembrane protein 199 Tmem199 Mus musculus (Mouse) TR32787_c3_g1_i1 Q8C3L1 CC032_MOUSE 8.00E-12 GO:0005737 cytoplasm IPR001305; Protein SSUH2 homolog (Protein ssu-2 homolog) Ssuh2 Ssu2 Mus musculus (Mouse) TR32787_c3_g2_i1 Q9Y2M2 CC032_HUMAN 2.00E-23 GO:0005737 cytoplasm Protein SSUH2 homolog (Protein ssu-2 homolog) SSUH2 C3orf32 FLS485 Homo sapiens (Human) TR32787_c5_g1_i1 A5PKF5 THA11_BOVIN 7.00E-09 GO:0003677; GO:0005825; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "DNA binding; half bridge of spindle pole body; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR006612; THAP domain-containing protein 11 THAP11 Bos taurus (Bovine) TR32793_c1_g1_i4 Q61458 CCNH_MOUSE 2.00E-35 GO:0008094; GO:0008353; GO:0070985; GO:0019907; GO:0004693; GO:0016538; GO:0005675; GO:0045944; GO:0000079; GO:0006366 DNA-dependent ATPase activity; RNA polymerase II carboxy-terminal domain kinase activity; TFIIK complex; cyclin-dependent protein kinase activating kinase holoenzyme complex; cyclin-dependent protein serine/threonine kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity; holo TFIIH complex; positive regulation of transcription from RNA polymerase II promoter; regulation of cyclin-dependent protein serine/threonine kinase activity; transcription from RNA polymerase II promoter IPR013763; IPR015429; IPR006671; IPR023598; IPR027081; Cyclin-H Ccnh Mus musculus (Mouse) TR32798_c4_g2_i1 E1BD59 TRI56_BOVIN 1.00E-18 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) TR32799_c0_g2_i1 Q9BT30 ALKB7_HUMAN 7.00E-59 GO:0051213; GO:0006631; GO:0046872; GO:0005759; GO:0070265; GO:0010883; GO:0006974 dioxygenase activity; fatty acid metabolic process; metal ion binding; mitochondrial matrix; necrotic cell death; regulation of lipid storage; response to DNA damage stimulus IPR027450; "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 7) (Spermatogenesis cell proliferation-related protein) (Spermatogenesis-associated protein 11)" ALKBH7 ABH7 SPATA11 UNQ6002/PRO34564 Homo sapiens (Human) TR32801_c2_g1_i1 Q62739 RAB3I_RAT 9.00E-43 GO:0017112; GO:0005856; GO:0005829; GO:0030027; GO:0005634; GO:0015031 Rab guanyl-nucleotide exchange factor activity; cytoskeleton; cytosol; lamellipodium; nucleus; protein transport IPR009449; Rab-3A-interacting protein (Rab3A-interacting protein) (Rabin-3) (SSX2-interacting protein) Rab3ip Rabin3 Rabin8 Rattus norvegicus (Rat) TR32802_c0_g1_i2 P97831 TWST2_RAT 7.00E-44 GO:0003677; GO:0030154; GO:0005737; GO:0007275; GO:0043066; GO:0045668; GO:0045892; GO:0005634; GO:0006351 "DNA binding; cell differentiation; cytoplasm; multicellular organismal development; negative regulation of apoptotic process; negative regulation of osteoblast differentiation; negative regulation of transcription, DNA-dependent; nucleus; transcription, DNA-dependent" IPR011598; Twist-related protein 2 Twist2 Rattus norvegicus (Rat) TR32804_c0_g1_i1 P62084 RS7_DANRE 2.00E-57 GO:0030686; GO:0022627; GO:0009790; GO:0030097; GO:0006364; GO:0051726; GO:0042274; GO:0032040; GO:0003735; GO:0006412 90S preribosome; cytosolic small ribosomal subunit; embryo development; hemopoiesis; rRNA processing; regulation of cell cycle; ribosomal small subunit biogenesis; small-subunit processome; structural constituent of ribosome; translation IPR000554; 40S ribosomal protein S7 rps7 zgc:73216 Danio rerio (Zebrafish) (Brachydanio rerio) TR32804_c0_g1_i4 P62083 RS7_RAT 7.00E-38 GO:0030686; GO:0022627; GO:0005815; GO:0006364; GO:0042274; GO:0032040; GO:0003735; GO:0006412 90S preribosome; cytosolic small ribosomal subunit; microtubule organizing center; rRNA processing; ribosomal small subunit biogenesis; small-subunit processome; structural constituent of ribosome; translation IPR000554; 40S ribosomal protein S7 (S8) Rps7 Rattus norvegicus (Rat) TR32808_c5_g1_i5 Q3MHZ8 LEG9_BOVIN 2.00E-06 GO:0030246; GO:0005737; GO:0005576 carbohydrate binding; cytoplasm; extracellular region IPR008985; IPR013320; IPR001079; Galectin-9 (Gal-9) LGALS9 Bos taurus (Bovine) TR32809_c0_g1_i1 Q9R1E6 ENPP2_MOUSE 1.00E-16 GO:0047391; GO:0005509; GO:0006935; GO:0005615; GO:0006955; GO:0005887; GO:0004622; GO:0003676; GO:0004551; GO:0034638; GO:0004528; GO:0030247; GO:0005044; GO:0008270 alkylglycerophosphoethanolamine phosphodiesterase activity; calcium ion binding; chemotaxis; extracellular space; immune response; integral to plasma membrane; lysophospholipase activity; nucleic acid binding; nucleotide diphosphatase activity; phosphatidylcholine catabolic process; phosphodiesterase I activity; polysaccharide binding; scavenger receptor activity; zinc ion binding IPR017849; IPR017850; IPR001604; IPR024873; IPR020821; IPR002591; IPR020436; IPR001212; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP 2) (EC 3.1.4.39) (Autotaxin) (Extracellular lysophospholipase D) (LysoPLD) Enpp2 Npps2 Pdnp2 Mus musculus (Mouse) TR32809_c2_g1_i1 Q0VA77 ENPP4_XENTR 1.00E-18 GO:0047710; GO:0007596; GO:0016021; GO:0005886 bis(5'-adenosyl)-triphosphatase activity; blood coagulation; integral to membrane; plasma membrane IPR017849; IPR017850; IPR024873; IPR002591; Bis(5'-adenosyl)-triphosphatase enpp4 (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 4) (E-NPP 4) (NPP-4) enpp4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR32809_c2_g3_i1 Q566N0 ENPP4_DANRE 3.00E-19 GO:0047710; GO:0007596; GO:0016021; GO:0005886 bis(5'-adenosyl)-triphosphatase activity; blood coagulation; integral to membrane; plasma membrane IPR017849; IPR017850; IPR024873; IPR002591; Bis(5'-adenosyl)-triphosphatase enpp4 (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 4) (E-NPP 4) (NPP-4) enpp4 zgc:113299 Danio rerio (Zebrafish) (Brachydanio rerio) TR32809_c3_g1_i1 Q9UJA9 ENPP5_HUMAN 2.00E-28 GO:0007154; GO:0005576; GO:0016787; GO:0016021; GO:0005886 cell communication; extracellular region; hydrolase activity; integral to membrane; plasma membrane IPR017849; IPR017850; IPR024873; IPR002591; Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (E-NPP 5) (NPP-5) (EC 3.1.-.-) ENPP5 UNQ550/PRO1107 Homo sapiens (Human) TR32811_c2_g1_i1 Q6ZPJ0 TEX2_MOUSE 6.00E-08 GO:0016021; GO:0005543 integral to membrane; phospholipid binding IPR019411; IPR001849; Testis-expressed sequence 2 protein Tex2 Kiaa1738 Mus musculus (Mouse) TR32811_c4_g2_i1 Q8IWB9 TEX2_HUMAN 5.00E-100 GO:0016021; GO:0005543; GO:0007165; GO:0006665 integral to membrane; phospholipid binding; signal transduction; sphingolipid metabolic process IPR019411; IPR001849; Testis-expressed sequence 2 protein (Transmembrane protein 96) TEX2 KIAA1738 TMEM96 Homo sapiens (Human) TR32812_c7_g1_i1 P53804 TTC3_HUMAN 2.00E-29 GO:0005739; GO:0010771; GO:0045665; GO:0005634; GO:0070936; GO:0006511; GO:0004842; GO:0005773; GO:0008270 mitochondrion; negative regulation of cell morphogenesis involved in differentiation; negative regulation of neuron differentiation; nucleus; protein K48-linked ubiquitination; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; vacuole; zinc ion binding IPR013026; IPR011990; IPR001440; IPR019734; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TTC3 (EC 6.3.2.-) (Protein DCRR1) (RING finger protein 105) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3) TTC3 DCRR1 RNF105 TPRD Homo sapiens (Human) TR32816_c1_g1_i2 Q502P7 BANP_DANRE 1.00E-76 GO:0003677; GO:0007049; GO:0016568; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cell cycle; chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR018379; Protein BANP banp zgc:111954 Danio rerio (Zebrafish) (Brachydanio rerio) TR32816_c1_g1_i4 Q502P7 BANP_DANRE 2.00E-76 GO:0003677; GO:0007049; GO:0016568; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cell cycle; chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR018379; Protein BANP banp zgc:111954 Danio rerio (Zebrafish) (Brachydanio rerio) TR32818_c3_g1_i1 Q96GP6 SREC2_HUMAN 3.00E-13 GO:0007157; GO:0016021; GO:0005044 P16333 heterophilic cell-cell adhesion; integral to membrane; scavenger receptor activity IPR000742; IPR013032; IPR002049; IPR009030; Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) TR32818_c3_g1_i2 P59222 SREC2_MOUSE 1.00E-09 GO:0007157; GO:0016021; GO:0005044 heterophilic cell-cell adhesion; integral to membrane; scavenger receptor activity IPR000742; IPR013032; IPR009030; Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) TR32818_c3_g1_i3 Q06807 TIE2_BOVIN 9.00E-16 GO:0005524; GO:0048014; GO:0005884; GO:0016324; GO:0009925; GO:0009986; GO:0005911; GO:0005737; GO:0001935; GO:0005576; GO:0005925; GO:0060347; GO:0005887; GO:0045121; GO:0005902; GO:0016525; GO:2000352; GO:0070374; GO:2000251; GO:0045766; GO:0010595; GO:0051894; GO:0043552; GO:0014068; GO:0051897; GO:0001934; GO:0046777; GO:0051259; GO:0004713; GO:0032878; GO:0002040; GO:0001725; GO:0034446; GO:0004714 ATP binding; Tie signaling pathway; actin filament; apical plasma membrane; basal plasma membrane; cell surface; cell-cell junction; cytoplasm; endothelial cell proliferation; extracellular region; focal adhesion; heart trabecula formation; integral to plasma membrane; membrane raft; microvillus; negative regulation of angiogenesis; negative regulation of endothelial cell apoptotic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of actin cytoskeleton reorganization; positive regulation of angiogenesis; positive regulation of endothelial cell migration; positive regulation of focal adhesion assembly; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of protein phosphorylation; protein autophosphorylation; protein oligomerization; protein tyrosine kinase activity; regulation of establishment or maintenance of cell polarity; sprouting angiogenesis; stress fiber; substrate adhesion-dependent cell spreading; transmembrane receptor protein tyrosine kinase activity IPR000742; IPR013032; IPR002049; IPR003961; IPR007110; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR018941; IPR008266; IPR020635; Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TIE-2) (CD antigen CD202b) TEK TIE-2 TIE2 Bos taurus (Bovine) TR32819_c1_g1_i1 P16157 ANK1_HUMAN 2.00E-38 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR32819_c1_g1_i2 G5E8K5 ANK3_MOUSE 1.00E-34 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR32819_c1_g1_i3 Q9ERK0 RIPK4_MOUSE 5.00E-30 GO:0005524; GO:0005737; GO:0016020; GO:0004674 Q6Q0C0 ATP binding; cytoplasm; membrane; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR017441; IPR008271; Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-associated protein kinase) (PKC-regulated protein kinase) Ripk4 Ankrd3 Pkk Mus musculus (Mouse) TR32819_c1_g1_i4 P16157 ANK1_HUMAN 4.00E-41 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR32820_c2_g1_i1 Q9W770 SPON1_CHICK 4.00E-35 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR002861; IPR009465; IPR000884; Spondin-1 (F-spondin) SPON1 Gallus gallus (Chicken) TR32820_c4_g1_i1 Q8BMS2 SPON2_MOUSE 5.00E-22 GO:0007155; GO:0045087; GO:0046872; GO:0005578 cell adhesion; innate immune response; metal ion binding; proteinaceous extracellular matrix IPR009465; IPR000884; Spondin-2 (Mindin) Spon2 Mus musculus (Mouse) TR32820_c4_g1_i2 Q8CGM1 BAI2_MOUSE 3.00E-11 GO:0004930; GO:0016021; GO:0016525; GO:0007218; GO:0007422; GO:0005886 Q06547 G-protein coupled receptor activity; integral to membrane; negative regulation of angiogenesis; neuropeptide signaling pathway; peripheral nervous system development; plasma membrane IPR022624; IPR017981; IPR008077; IPR001879; IPR000832; IPR000203; IPR000884; Brain-specific angiogenesis inhibitor 2 Bai2 Mus musculus (Mouse) TR32820_c4_g1_i3 Q700K0 SSPO_RAT 7.00E-11 GO:0007155; GO:0005615 cell adhesion; extracellular space IPR000421; IPR006207; IPR008979; IPR023415; IPR002172; IPR000884; IPR002919; IPR014853; IPR006552; IPR001007; IPR001846; SCO-spondin Sspo Rattus norvegicus (Rat) TR32820_c4_g1_i4 Q9W770 SPON1_CHICK 3.00E-28 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR002861; IPR009465; IPR000884; Spondin-1 (F-spondin) SPON1 Gallus gallus (Chicken) TR32821_c4_g1_i1 O60308 CE104_HUMAN 7.00E-127 GO:0005814 centriole IPR011989; IPR016024; IPR008979; Centrosomal protein of 104 kDa (Cep104) CEP104 KIAA0562 Homo sapiens (Human) TR32825_c0_g1_i2 Q6NY82 UBE2F_DANRE 2.00E-09 GO:0005524; GO:0019788; GO:0045116 ATP binding; NEDD8 ligase activity; protein neddylation IPR000608; IPR023313; IPR016135; Protein modification; protein neddylation. NEDD8-conjugating enzyme UBE2F (EC 6.3.2.-) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8-conjugating enzyme 2) (Ubiquitin-conjugating enzyme E2 F) ube2f ch211-93g23.1 zgc:77005 Danio rerio (Zebrafish) (Brachydanio rerio) TR32825_c0_g1_i3 P61082 UBC12_MOUSE 4.00E-20 GO:0005524; GO:0019788; GO:0045116; GO:0018169; GO:0004842 ATP binding; NEDD8 ligase activity; protein neddylation; ribosomal S6-glutamic acid ligase activity; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein neddylation. NEDD8-conjugating enzyme Ubc12 (EC 6.3.2.-) (NEDD8 carrier protein) (NEDD8 protein ligase) (Ubiquitin-conjugating enzyme E2 M) Ube2m Ubc-rs2 Ubc12 Mus musculus (Mouse) TR32829_c4_g1_i1 Q6DGZ0 CCD75_DANRE 9.00E-06 GO:0003676 nucleic acid binding IPR025239; IPR000467; G patch domain-containing protein 11 (Coiled-coil domain-containing protein 75) gpatch11 ccdc75 zgc:92714 Danio rerio (Zebrafish) (Brachydanio rerio) TR32829_c4_g1_i2 Q9QX47 SON_MOUSE 2.00E-69 GO:0003677; GO:0003723; GO:0008380; GO:0000910; GO:0006397; GO:0000226; GO:0043066; GO:0016607; GO:0043484; GO:0051726; GO:0006355; GO:0006351 "DNA binding; RNA binding; RNA splicing; cytokinesis; mRNA processing; microtubule cytoskeleton organization; negative regulation of apoptotic process; nuclear speck; regulation of RNA splicing; regulation of cell cycle; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR014720; IPR000467; IPR017986; Protein SON (Negative regulatory element-binding protein) (NRE-binding protein) Son Nrebp Mus musculus (Mouse) TR32831_c1_g1_i1 Q8N2E2 VWDE_HUMAN 2.00E-09 GO:0005576 extracellular region IPR000742; IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) TR32831_c8_g1_i1 F1NBL0 MUC6_CHICK 4.00E-07 GO:0005576 extracellular region IPR002919; IPR014853; IPR001007; IPR001846; "Mucin-6 (Ovomucin, beta-subunit) (Fragment)" MUC6 Gallus gallus (Chicken) TR32834_c5_g1_i1 Q5W041 ARMC3_HUMAN 2.00E-71 IPR011989; IPR016024; IPR000225; Armadillo repeat-containing protein 3 (Beta-catenin-like protein) (Cancer/testis antigen 81) (CT81) (KU-CT-1) ARMC3 Homo sapiens (Human) TR32834_c5_g1_i2 Q4WVW4 VAC8_ASPFU 2.00E-12 GO:0071255; GO:0071563; GO:0000329; GO:0016236; GO:0071561; GO:0071562; GO:0042144; GO:0000011 "CVT vesicle assembly; Myo2p-Vac17p-Vac8p transport complex; fungal-type vacuole membrane; macroautophagy; nucleus-vacuole junction; nucleus-vacuole junction assembly; vacuole fusion, non-autophagic; vacuole inheritance" IPR011989; IPR016024; IPR000225; IPR026958; Vacuolar protein 8 vac8 AFUA_5G13540 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) TR32834_c5_g1_i3 Q5W041 ARMC3_HUMAN 2.00E-106 IPR011989; IPR016024; IPR000225; Armadillo repeat-containing protein 3 (Beta-catenin-like protein) (Cancer/testis antigen 81) (CT81) (KU-CT-1) ARMC3 Homo sapiens (Human) TR32836_c0_g1_i2 Q06S87 HIUH_DANRE 1.00E-31 GO:0016811; GO:0033971; GO:0005777; GO:0006144; GO:0006810; GO:0019628 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; hydroxyisourate hydrolase activity; peroxisome; purine nucleobase metabolic process; transport; urate catabolic process" IPR014306; IPR023418; IPR000895; IPR023416; Purine metabolism; urate degradation; (S)-allantoin from urate: step 2/3. 5-hydroxyisourate hydrolase (HIU hydrolase) (HIUHase) (EC 3.5.2.17) (Transthyretin-related protein) urah Danio rerio (Zebrafish) (Brachydanio rerio) TR32836_c0_g1_i3 Q8XB75 HIUH_ECO57 3.00E-25 GO:0033971; GO:0042597; GO:0006144; GO:0006810 hydroxyisourate hydrolase activity; periplasmic space; purine nucleobase metabolic process; transport IPR014306; IPR023418; IPR000895; IPR023416; IPR023419; 5-hydroxyisourate hydrolase (HIU hydrolase) (HIUHase) (EC 3.5.2.17) (Transthyretin-like protein) (TLP) hiuH Z3062 ECs2708 Escherichia coli O157:H7 TR32836_c0_g1_i4 Q9CRB3 HIUH_MOUSE 4.00E-31 GO:0016787; GO:0033971; GO:0005739; GO:0005777; GO:0006144; GO:0006810; GO:0019628 hydrolase activity; hydroxyisourate hydrolase activity; mitochondrion; peroxisome; purine nucleobase metabolic process; transport; urate catabolic process IPR014306; IPR000895; IPR023416; IPR023419; Purine metabolism; urate degradation; (S)-allantoin from urate: step 2/3. 5-hydroxyisourate hydrolase (HIU hydrolase) (HIUHase) (EC 3.5.2.17) (Transthyretin-related protein) Urah Mus musculus (Mouse) TR32836_c0_g1_i6 Q06S87 HIUH_DANRE 2.00E-12 GO:0016811; GO:0033971; GO:0005777; GO:0006144; GO:0006810; GO:0019628 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; hydroxyisourate hydrolase activity; peroxisome; purine nucleobase metabolic process; transport; urate catabolic process" IPR014306; IPR023418; IPR000895; IPR023416; Purine metabolism; urate degradation; (S)-allantoin from urate: step 2/3. 5-hydroxyisourate hydrolase (HIU hydrolase) (HIUHase) (EC 3.5.2.17) (Transthyretin-related protein) urah Danio rerio (Zebrafish) (Brachydanio rerio) TR32836_c0_g1_i7 Q9CRB3 HIUH_MOUSE 1.00E-12 GO:0016787; GO:0033971; GO:0005739; GO:0005777; GO:0006144; GO:0006810; GO:0019628 hydrolase activity; hydroxyisourate hydrolase activity; mitochondrion; peroxisome; purine nucleobase metabolic process; transport; urate catabolic process IPR014306; IPR000895; IPR023416; IPR023419; Purine metabolism; urate degradation; (S)-allantoin from urate: step 2/3. 5-hydroxyisourate hydrolase (HIU hydrolase) (HIUHase) (EC 3.5.2.17) (Transthyretin-related protein) Urah Mus musculus (Mouse) TR32837_c3_g1_i2 P08548 LIN1_NYCCO 6.00E-09 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR32837_c3_g1_i3 P14381 YTX2_XENLA 7.00E-18 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR32838_c3_g1_i1 Q8BN21 VRK2_MOUSE 2.00E-25 GO:0005524; GO:0034599; GO:0005789; GO:0016021; GO:0031966; GO:0005634; GO:0046777; GO:0004674; GO:0043408; GO:2000659 ATP binding; cellular response to oxidative stress; endoplasmic reticulum membrane; integral to membrane; mitochondrial membrane; nucleus; protein autophosphorylation; protein serine/threonine kinase activity; regulation of MAPK cascade; regulation of interleukin-1-mediated signaling pathway IPR011009; IPR000719; IPR008271; Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2) Vrk2 Mus musculus (Mouse) TR32838_c3_g1_i2 P67963 KC1A_XENLA 0 GO:0005524; GO:0016055; GO:0051301; GO:0000777; GO:0005737; GO:0005815; GO:0007067; GO:0016607; GO:0004674 ATP binding; Wnt receptor signaling pathway; cell division; condensed chromosome kinetochore; cytoplasm; microtubule organizing center; mitosis; nuclear speck; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) csnk1a1 Xenopus laevis (African clawed frog) TR32840_c1_g1_i1 Q8R322 GLE1_MOUSE 4.00E-52 GO:0005737; GO:0005643; GO:0016973; GO:0015031 cytoplasm; nuclear pore; poly(A)+ mRNA export from nucleus; protein transport IPR012476; Nucleoporin GLE1 (GLE1-like protein) Gle1 Gle1l Mus musculus (Mouse) TR32840_c1_g1_i4 Q8R322 GLE1_MOUSE 6.00E-53 GO:0005737; GO:0005643; GO:0016973; GO:0015031 cytoplasm; nuclear pore; poly(A)+ mRNA export from nucleus; protein transport IPR012476; Nucleoporin GLE1 (GLE1-like protein) Gle1 Gle1l Mus musculus (Mouse) TR32841_c0_g2_i1 Q5R5L7 ARRD3_PONAB 1.00E-25 GO:0005737 cytoplasm IPR011021; IPR011022; IPR014756; Arrestin domain-containing protein 3 ARRDC3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR32841_c0_g2_i2 Q8TBH0 ARRD2_HUMAN 4.00E-19 GO:0031410; GO:0005886; GO:0007165 cytoplasmic vesicle; plasma membrane; signal transduction IPR011021; IPR014752; IPR011022; IPR014756; Arrestin domain-containing protein 2 ARRDC2 PP2703 Homo sapiens (Human) TR32841_c0_g2_i4 Q99KN1 ARRD1_MOUSE 3.00E-19 IPR011021; IPR011022; IPR014756; Arrestin domain-containing protein 1 Arrdc1 Mus musculus (Mouse) TR32844_c0_g1_i1 Q9P291 ARMX1_HUMAN 2.00E-15 GO:0016021 integral to membrane IPR011989; IPR006911; IPR016024; IPR000225; Armadillo repeat-containing X-linked protein 1 (ARM protein lost in epithelial cancers on chromosome X 1) (Protein ALEX1) ARMCX1 ALEX1 AD032 Homo sapiens (Human) TR32844_c0_g1_i5 Q9P291 ARMX1_HUMAN 2.00E-15 GO:0016021 integral to membrane IPR011989; IPR006911; IPR016024; IPR000225; Armadillo repeat-containing X-linked protein 1 (ARM protein lost in epithelial cancers on chromosome X 1) (Protein ALEX1) ARMCX1 ALEX1 AD032 Homo sapiens (Human) TR32846_c0_g1_i2 P53563 B2CL1_RAT 7.00E-16 GO:0005813; GO:0043027; GO:0000910; GO:0016021; GO:0005741; GO:0007093; GO:0043066; GO:0031965; GO:0001541; GO:0042542; GO:0001666; GO:0002931; GO:0010288; GO:0014070; GO:0043434 O35303 centrosome; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytokinesis; integral to membrane; mitochondrial outer membrane; mitotic cell cycle checkpoint; negative regulation of apoptotic process; nuclear membrane; ovarian follicle development; response to hydrogen peroxide; response to hypoxia; response to ischemia; response to lead ion; response to organic cyclic compound; response to peptide hormone stimulus IPR013279; IPR002475; IPR004725; IPR020717; IPR020726; IPR020728; IPR003093; IPR020731; IPR026298; Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) Bcl2l1 Bclx Blc2l Rattus norvegicus (Rat) TR32848_c0_g2_i3 Q687X5 STEA4_HUMAN 1.00E-91 GO:0000139; GO:0045444; GO:0016021; GO:0006811; GO:0055072; GO:0046872; GO:0016491; GO:0005886 Golgi membrane; fat cell differentiation; integral to membrane; ion transport; iron ion homeostasis; metal ion binding; oxidoreductase activity; plasma membrane IPR013130; IPR016040; "Metalloreductase STEAP4 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 4) (SixTransMembrane protein of prostate 2) (Tumor necrosis factor, alpha-induced protein 9)" STEAP4 STAMP2 TNFAIP9 Homo sapiens (Human) TR3285_c0_g1_i1 Q5S003 SPG17_MOUSE 3.00E-07 GO:0005737; GO:0005874; GO:0036126 Q9JLI7 cytoplasm; microtubule; sperm flagellum IPR026173; Sperm-associated antigen 17 (Projection protein PF6 homolog) Spag17 Mus musculus (Mouse) TR32850_c3_g2_i1 O55052 MIF_MERUN 3.00E-07 GO:0005737; GO:0004167; GO:0005615; GO:0006954; GO:0045087; GO:0050178 cytoplasm; dopachrome isomerase activity; extracellular space; inflammatory response; innate immune response; phenylpyruvate tautomerase activity IPR001398; IPR019829; IPR014347; Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) MIF Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) TR32851_c4_g3_i4 Q4GXH6 RL17_BIPLU 2.00E-79 GO:0015934; GO:0003735; GO:0006412 large ribosomal subunit; structural constituent of ribosome; translation IPR001063; IPR018260; IPR005721; 60S ribosomal protein L17 RpL17 Biphyllus lunatus (Beetle) TR32851_c4_g3_i5 Q4PM54 RL17_IXOSC 4.00E-85 GO:0015934; GO:0003735; GO:0006412 large ribosomal subunit; structural constituent of ribosome; translation IPR001063; IPR018260; IPR005721; 60S ribosomal protein L17 RpL17 Ixodes scapularis (Black-legged tick) (Deer tick) TR32854_c0_g1_i2 Q14135 VGLL4_HUMAN 2.00E-06 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006627; IPR028184; Transcription cofactor vestigial-like protein 4 (Vgl-4) VGLL4 KIAA0121 Homo sapiens (Human) TR32855_c0_g1_i1 Q4VBS4 AMP1D_DANRE 7.00E-103 GO:0004177; GO:0009987; GO:0046872; GO:0008235; GO:0005739; GO:0006508 aminopeptidase activity; cellular process; metal ion binding; metalloexopeptidase activity; mitochondrion; proteolysis IPR001714; IPR000994; IPR002467; "Methionine aminopeptidase 1D, mitochondrial (MAP 1D) (MetAP 1D) (EC 3.4.11.18) (Methionyl aminopeptidase type 1D, mitochondrial) (Peptidase M 1D)" metap1d map1d zgc:110461 Danio rerio (Zebrafish) (Brachydanio rerio) TR32857_c1_g1_i1 P57088 TMM33_HUMAN 7.00E-64 GO:0016021; GO:0042470 integral to membrane; melanosome IPR005344; Transmembrane protein 33 (Protein DB83) TMEM33 DB83 Homo sapiens (Human) TR32858_c0_g1_i2 Q99PP7 TRI33_MOUSE 2.00E-08 GO:0003677; GO:0070412; GO:0070410; GO:0016874; GO:0030514; GO:0005634; GO:0016567; GO:0006355; GO:0017015; GO:0006351; GO:0008270 "DNA binding; R-SMAD binding; co-SMAD binding; ligase activity; negative regulation of BMP signaling pathway; nucleus; protein ubiquitination; regulation of transcription, DNA-dependent; regulation of transforming growth factor beta receptor signaling pathway; transcription, DNA-dependent; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) Trim33 Kiaa1113 Mus musculus (Mouse) TR32858_c0_g1_i4 Q62318 TIF1B_MOUSE 1.00E-10 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0003713; GO:0003714; GO:0006351; GO:0004842; GO:0008270 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; transcription coactivator activity; transcription corepressor activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-A-interacting protein) (KRIP-1) (Tripartite motif-containing protein 28) Trim28 Krip1 Tif1b Mus musculus (Mouse) TR32858_c0_g1_i5 Q62318 TIF1B_MOUSE 1.00E-10 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0003713; GO:0003714; GO:0006351; GO:0004842; GO:0008270 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; transcription coactivator activity; transcription corepressor activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-A-interacting protein) (KRIP-1) (Tripartite motif-containing protein 28) Trim28 Krip1 Tif1b Mus musculus (Mouse) TR32859_c0_g1_i1 Q19673 TYR3_CAEEL 4.00E-09 GO:0046872; GO:0004497 metal ion binding; monooxygenase activity IPR003582; IPR002227; IPR008922; Putative tyrosinase-like protein tyr-3 tyr-3 F21C3.2 Caenorhabditis elegans TR32859_c0_g1_i2 P42674 BP10_PARLI 1.00E-37 GO:0005938; GO:0005615; GO:0004222; GO:0048471; GO:0006508; GO:0008270 cell cortex; extracellular space; metalloendopeptidase activity; perinuclear region of cytoplasm; proteolysis; zinc ion binding IPR000859; IPR000742; IPR013032; IPR024079; IPR001506; IPR006026; IPR017369; Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) TR32859_c0_g1_i3 Q9N2V2 NAS30_CAEEL 3.00E-42 GO:0004222; GO:0006508; GO:0008270 metalloendopeptidase activity; proteolysis; zinc ion binding IPR000859; IPR024079; IPR001506; IPR006026; Zinc metalloproteinase nas-30 (EC 3.4.24.21) (Nematode astacin 30) nas-30 Y95B8A.1 Caenorhabditis elegans TR32860_c0_g2_i1 Q9R045 ANGL2_MOUSE 4.00E-49 GO:0005576 extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-related protein 2 (Angiopoietin-like protein 2) Angptl2 Arp2 Mus musculus (Mouse) TR32860_c1_g1_i1 Q29042 FCN1_PIG 5.00E-61 GO:0005581; GO:0045087; GO:0046872 collagen; innate immune response; metal ion binding IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Ficolin-A) (Ficolin-alpha) FCN1 Sus scrofa (Pig) TR32860_c1_g1_i2 E2IYB3 FCNV1_VARKO 2.00E-23 GO:0005576 extracellular region IPR008160; IPR014716; IPR002181; Veficolin-1 (Fragment) Varanus komodoensis (Komodo dragon) TR32860_c1_g1_i3 O00602 FCN1_HUMAN 8.00E-63 GO:0003823; GO:0005509; GO:0030246; GO:0005581; GO:0001867; GO:0005576; GO:0008228 Q2TS39 "antigen binding; calcium ion binding; carbohydrate binding; collagen; complement activation, lectin pathway; extracellular region; opsonization" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) FCN1 FCNM Homo sapiens (Human) TR32862_c1_g1_i2 Q9NXK8 FXL12_HUMAN 2.00E-29 GO:0005737; GO:0016567; GO:0000151; GO:0006511 P49918; Q9H0A6 cytoplasm; protein ubiquitination; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process IPR001810; Protein modification; protein ubiquitination. F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12) FBXL12 FBL12 Homo sapiens (Human) TR32863_c0_g1_i1 Q567B1 OTU1_DANRE 1.00E-24 GO:0030433; GO:0006520; GO:0030968; GO:0046872; GO:0035871; GO:1990167; GO:0035523; GO:1990168; GO:0071108; GO:0070536; GO:0004843 ER-associated protein catabolic process; cellular amino acid metabolic process; endoplasmic reticulum unfolded protein response; metal ion binding; protein K11-linked deubiquitination; protein K27-linked deubiquitination; protein K29-linked deubiquitination; protein K33-linked deubiquitination; protein K48-linked deubiquitination; protein K63-linked deubiquitination; ubiquitin-specific protease activity IPR003323; IPR027933; IPR000626; Ubiquitin thioesterase OTU1 (EC 3.4.19.12) yod1 zgc:112182 Danio rerio (Zebrafish) (Brachydanio rerio) TR32863_c0_g1_i3 Q567B1 OTU1_DANRE 2.00E-93 GO:0030433; GO:0006520; GO:0030968; GO:0046872; GO:0035871; GO:1990167; GO:0035523; GO:1990168; GO:0071108; GO:0070536; GO:0004843 ER-associated protein catabolic process; cellular amino acid metabolic process; endoplasmic reticulum unfolded protein response; metal ion binding; protein K11-linked deubiquitination; protein K27-linked deubiquitination; protein K29-linked deubiquitination; protein K33-linked deubiquitination; protein K48-linked deubiquitination; protein K63-linked deubiquitination; ubiquitin-specific protease activity IPR003323; IPR027933; IPR000626; Ubiquitin thioesterase OTU1 (EC 3.4.19.12) yod1 zgc:112182 Danio rerio (Zebrafish) (Brachydanio rerio) TR32864_c1_g2_i1 P48508 GSH0_RAT 4.00E-55 GO:0006534; GO:0006536; GO:0004357; GO:0035226; GO:0017109; GO:0006750; GO:0043524; GO:0035229; GO:0046982; GO:0050880; GO:0051900; GO:0042493; GO:0051409; GO:0006979 cysteine metabolic process; glutamate metabolic process; glutamate-cysteine ligase activity; glutamate-cysteine ligase catalytic subunit binding; glutamate-cysteine ligase complex; glutathione biosynthetic process; negative regulation of neuron apoptotic process; positive regulation of glutamate-cysteine ligase activity; protein heterodimerization activity; regulation of blood vessel size; regulation of mitochondrial depolarization; response to drug; response to nitrosative stress; response to oxidative stress IPR023210; Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit) Gclm Glclr Rattus norvegicus (Rat) TR32864_c2_g1_i2 A0JPE9 GLPK5_DANRE 0 GO:0005524; GO:0019563; GO:0004370 ATP binding; glycerol catabolic process; glycerol kinase activity IPR018485; IPR018483; IPR018484; Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. Putative glycerol kinase 5 (GK 5) (Glycerokinase 5) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 5) gk5 zgc:152983 Danio rerio (Zebrafish) (Brachydanio rerio) TR32864_c2_g1_i3 Q8BX05 GLPK5_MOUSE 0 GO:0005524; GO:0019563; GO:0004370 ATP binding; glycerol catabolic process; glycerol kinase activity IPR018485; IPR018483; IPR018484; Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. Putative glycerol kinase 5 (GK 5) (Glycerokinase 5) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 5) Gk5 Mus musculus (Mouse) TR32864_c2_g1_i5 A0JPE9 GLPK5_DANRE 2.00E-100 GO:0005524; GO:0019563; GO:0004370 ATP binding; glycerol catabolic process; glycerol kinase activity IPR018485; IPR018483; IPR018484; Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. Putative glycerol kinase 5 (GK 5) (Glycerokinase 5) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 5) gk5 zgc:152983 Danio rerio (Zebrafish) (Brachydanio rerio) TR32865_c5_g5_i1 P21329 RTJK_DROFU 2.00E-10 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) TR32867_c0_g1_i1 Q8T2J9 MCCB_DICDI 5.00E-83 GO:0005524; GO:0006552; GO:0004485; GO:0005759 ATP binding; leucine catabolic process; methylcrotonoyl-CoA carboxylase activity; mitochondrial matrix IPR000022; IPR011763; IPR011762; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3. "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta)" mccb mccc2 DDB_G0271960 Dictyostelium discoideum (Slime mold) TR32867_c0_g2_i2 Q21LR0 ACCA_SACD2 1.00E-05 GO:0005524; GO:0003989; GO:0009317; GO:0006633; GO:2001295 ATP binding; acetyl-CoA carboxylase activity; acetyl-CoA carboxylase complex; fatty acid biosynthetic process; malonyl-CoA biosynthetic process IPR001095; IPR011763; Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (ACCase subunit alpha) (Acetyl-CoA carboxylase carboxyltransferase subunit alpha) (EC 6.4.1.2) accA Sde_1107 Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024) TR32873_c1_g1_i1 Q9TUD6 FUT1_PANTR 1.00E-24 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" FUT1 Pan troglodytes (Chimpanzee) TR32873_c1_g1_i2 Q10983 FUT2_RABIT 1.00E-27 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Secretor blood group alpha-2-fucosyltransferase)" FUT2 RFT-II SEC1 Oryctolagus cuniculus (Rabbit) TR32874_c0_g1_i2 Q96F15 GIMA5_HUMAN 2.00E-27 GO:0005525; GO:0030217; GO:0043029; GO:0016021; GO:0005764; GO:0005741; GO:0043011; GO:0050868; GO:0043066; GO:0032689; GO:0050995; GO:0045019; GO:0032831; GO:0010524; GO:0045588; GO:0002925; GO:0045838; GO:0002729; GO:0045954; GO:0046902; GO:0001659 "GTP binding; T cell differentiation; T cell homeostasis; integral to membrane; lysosome; mitochondrial outer membrane; myeloid dendritic cell differentiation; negative regulation of T cell activation; negative regulation of apoptotic process; negative regulation of interferon-gamma production; negative regulation of lipid catabolic process; negative regulation of nitric oxide biosynthetic process; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of calcium ion transport into cytosol; positive regulation of gamma-delta T cell differentiation; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of membrane potential; positive regulation of natural killer cell cytokine production; positive regulation of natural killer cell mediated cytotoxicity; regulation of mitochondrial membrane permeability; temperature homeostasis" IPR006703; IPR027417; GTPase IMAP family member 5 (Immunity-associated nucleotide 4-like 1 protein) (Immunity-associated nucleotide 5 protein) (IAN-5) (hIAN5) (Immunity-associated protein 3) GIMAP5 IAN4L1 IAN5 IMAP3 Homo sapiens (Human) TR32874_c0_g1_i3 Q9NUV9 GIMA4_HUMAN 9.00E-37 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR32875_c9_g2_i1 Q32KJ6 GALNS_RAT 3.00E-111 GO:0043890; GO:0005764; GO:0046872 N-acetylgalactosamine-6-sulfatase activity; lysosome; metal ion binding IPR017849; IPR017850; IPR000917; IPR024607; N-acetylgalactosamine-6-sulfatase (EC 3.1.6.4) (Chondroitinsulfatase) (Chondroitinase) (Galactose-6-sulfate sulfatase) (N-acetylgalactosamine-6-sulfate sulfatase) (GalNAc6S sulfatase) Galns Rattus norvegicus (Rat) TR32876_c0_g1_i1 P62317 SMD2_MOUSE 1.00E-51 GO:0008380; GO:0005689; GO:0071013; GO:0006397; GO:0030532 RNA splicing; U12-type spliceosomal complex; catalytic step 2 spliceosome; mRNA processing; small nuclear ribonucleoprotein complex IPR010920; IPR001163; IPR006649; IPR027248; Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2) Snrpd2 Mus musculus (Mouse) TR32878_c0_g1_i1 Q6ZS10 CL17A_HUMAN 5.00E-20 GO:0009986; GO:0042806; GO:0016021; GO:0005537; GO:0046872 cell surface; fucose binding; integral to membrane; mannose binding; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; "C-type lectin domain family 17, member A (Prolectin)" CLEC17A Homo sapiens (Human) TR32878_c0_g1_i3 P35247 SFTPD_HUMAN 9.00E-06 GO:0030246; GO:0005581; GO:0030139; GO:0005576; GO:0005615; GO:0045087; GO:0048286; GO:0005764; GO:0048246; GO:0042130; GO:0045085; GO:0050766; GO:0072593; GO:0006898; GO:0007585; GO:0043129 carbohydrate binding; collagen; endocytic vesicle; extracellular region; extracellular space; innate immune response; lung alveolus development; lysosome; macrophage chemotaxis; negative regulation of T cell proliferation; negative regulation of interleukin-2 biosynthetic process; positive regulation of phagocytosis; reactive oxygen species metabolic process; receptor-mediated endocytosis; respiratory gaseous exchange; surfactant homeostasis IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; IPR015097; Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (Collectin-7) (Lung surfactant protein D) SFTPD COLEC7 PSPD SFTP4 Homo sapiens (Human) TR32878_c0_g1_i4 P02707 LECH_CHICK 2.00E-16 GO:0030246; GO:0006897; GO:0016021 carbohydrate binding; endocytosis; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; Hepatic lectin Gallus gallus (Chicken) TR32878_c0_g2_i1 Q5U9S1 MBL1_PIG 6.00E-06 GO:0005581; GO:0006958; GO:0001867; GO:0050830; GO:0005615; GO:0051873; GO:0005537; GO:0044130; GO:0050766 "collagen; complement activation, classical pathway; complement activation, lectin pathway; defense response to Gram-positive bacterium; extracellular space; killing by host of symbiont cells; mannose binding; negative regulation of growth of symbiont in host; positive regulation of phagocytosis" IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Mannose-binding protein A (MBP-A) (28 kDa mannan-binding protein monomeric subunit) (pMBP-28) (Mannan-binding lectin A) (MBL-A) (Mannose-binding lectin A) MBL1 MBL-A Sus scrofa (Pig) TR32880_c0_g1_i1 Q91VN0 LRP5_MOUSE 1.00E-08 GO:0044332; GO:0042813; GO:0060612; GO:0060033; GO:0009952; GO:1902262; GO:0048539; GO:0060349; GO:0046849; GO:0060444; GO:0060070; GO:0042074; GO:0060764; GO:0042632; GO:0008203; GO:0015026; GO:0048596; GO:0042733; GO:0060059; GO:0006897; GO:0005783; GO:0035426; GO:0001702; GO:0016021; GO:0005739; GO:0002076; GO:0005886; GO:0033690; GO:0051091; GO:0045944; GO:0043235; GO:0042981; GO:0046850; GO:0045598; GO:0061178; GO:0030278; GO:0061304; GO:0035019 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt-activated receptor activity; adipose tissue development; anatomical structure regression; anterior/posterior pattern specification; apoptotic process involved in patterning of blood vessels; bone marrow development; bone morphogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway; cell migration involved in gastrulation; cell-cell signaling involved in mammary gland development; cholesterol homeostasis; cholesterol metabolic process; coreceptor activity; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic retina morphogenesis in camera-type eye; endocytosis; endoplasmic reticulum; extracellular matrix-cell signaling; gastrulation with mouth forming second; integral to membrane; mitochondrion; osteoblast development; plasma membrane; positive regulation of osteoblast proliferation; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; receptor complex; regulation of apoptotic process; regulation of bone remodeling; regulation of fat cell differentiation; regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of ossification; retinal blood vessel morphogenesis; somatic stem cell maintenance IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7) (Lr3) Lrp5 Lrp7 Mus musculus (Mouse) TR32880_c0_g1_i2 P01130 LDLR_HUMAN 6.00E-09 GO:0005794; GO:0005509; GO:0042632; GO:0070508; GO:0008203; GO:0030669; GO:0005905; GO:0005769; GO:0010008; GO:0009897; GO:0005887; GO:0030299; GO:0005770; GO:0042159; GO:0042157; GO:0034362; GO:0030169; GO:0034383; GO:0005041; GO:0005764; GO:0019048; GO:0015914; GO:0007603; GO:0010867; GO:0010899; GO:0001523; GO:0044281; GO:0030229 Q8NBP7 "Golgi apparatus; calcium ion binding; cholesterol homeostasis; cholesterol import; cholesterol metabolic process; clathrin-coated endocytic vesicle membrane; coated pit; early endosome; endosome membrane; external side of plasma membrane; integral to plasma membrane; intestinal cholesterol absorption; late endosome; lipoprotein catabolic process; lipoprotein metabolic process; low-density lipoprotein particle; low-density lipoprotein particle binding; low-density lipoprotein particle clearance; low-density lipoprotein receptor activity; lysosome; modulation by virus of host morphology or physiology; phospholipid transport; phototransduction, visible light; positive regulation of triglyceride biosynthetic process; regulation of phosphatidylcholine catabolic process; retinoid metabolic process; small molecule metabolic process; very-low-density lipoprotein particle receptor activity" IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor (LDL receptor) LDLR Homo sapiens (Human) TR32880_c0_g1_i4 P01130 LDLR_HUMAN 3.00E-09 GO:0005794; GO:0005509; GO:0042632; GO:0070508; GO:0008203; GO:0030669; GO:0005905; GO:0005769; GO:0010008; GO:0009897; GO:0005887; GO:0030299; GO:0005770; GO:0042159; GO:0042157; GO:0034362; GO:0030169; GO:0034383; GO:0005041; GO:0005764; GO:0019048; GO:0015914; GO:0007603; GO:0010867; GO:0010899; GO:0001523; GO:0044281; GO:0030229 Q8NBP7 "Golgi apparatus; calcium ion binding; cholesterol homeostasis; cholesterol import; cholesterol metabolic process; clathrin-coated endocytic vesicle membrane; coated pit; early endosome; endosome membrane; external side of plasma membrane; integral to plasma membrane; intestinal cholesterol absorption; late endosome; lipoprotein catabolic process; lipoprotein metabolic process; low-density lipoprotein particle; low-density lipoprotein particle binding; low-density lipoprotein particle clearance; low-density lipoprotein receptor activity; lysosome; modulation by virus of host morphology or physiology; phospholipid transport; phototransduction, visible light; positive regulation of triglyceride biosynthetic process; regulation of phosphatidylcholine catabolic process; retinoid metabolic process; small molecule metabolic process; very-low-density lipoprotein particle receptor activity" IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor (LDL receptor) LDLR Homo sapiens (Human) TR32883_c1_g2_i1 Q8AVJ1 PRR5_XENLA 5.00E-34 IPR016159; IPR013745; Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) prr5 protor1 Xenopus laevis (African clawed frog) TR32883_c1_g2_i2 Q8AVJ1 PRR5_XENLA 2.00E-34 IPR016159; IPR013745; Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) prr5 protor1 Xenopus laevis (African clawed frog) TR32884_c0_g1_i1 P0CB82 NDUA9_PONPY 2.00E-81 GO:0003824; GO:0044237; GO:0050662; GO:0005759; GO:0055114; GO:0070469 catalytic activity; cellular metabolic process; coenzyme binding; mitochondrial matrix; oxidation-reduction process; respiratory chain IPR001509; IPR016040; "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (CI-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit)" NDUFA9 Pongo pygmaeus (Bornean orangutan) TR32886_c0_g2_i1 Q0MQD0 NDUB3_PONPY 2.00E-08 GO:0022900; GO:0016021; GO:0005747 electron transport chain; integral to membrane; mitochondrial respiratory chain complex I IPR012576; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (Complex I-B12) (CI-B12) (NADH-ubiquinone oxidoreductase B12 subunit) NDUFB3 Pongo pygmaeus (Bornean orangutan) TR32886_c0_g2_i2 Q02365 NDUB3_BOVIN 7.00E-07 GO:0022900; GO:0016021; GO:0005747 electron transport chain; integral to membrane; mitochondrial respiratory chain complex I IPR012576; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (Complex I-B12) (CI-B12) (NADH-ubiquinone oxidoreductase B12 subunit) NDUFB3 Bos taurus (Bovine) TR32889_c0_g2_i2 O62640 PIAP_PIG 3.00E-15 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR32889_c0_g2_i3 O08863 BIRC3_MOUSE 7.00E-15 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 P39429 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Inhibitor of apoptosis protein 1) (IAP-1) (mIAP-1) (mIAP1) Birc3 Birc2 Iap1 Mus musculus (Mouse) TR32889_c1_g2_i2 Q6IQU7 INT12_DANRE 8.00E-31 GO:0005634; GO:0008270 nucleus; zinc ion binding IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Integrator complex subunit 12 (Int12) ints12 zgc:86602 Danio rerio (Zebrafish) (Brachydanio rerio) TR3289_c0_g1_i1 P50427 STS_MOUSE 4.00E-21 GO:0005789; GO:0007565; GO:0016021; GO:0046872; GO:0008202; GO:0004773; GO:0008484 endoplasmic reticulum membrane; female pregnancy; integral to membrane; metal ion binding; steroid metabolic process; steryl-sulfatase activity; sulfuric ester hydrolase activity IPR017849; IPR017850; IPR000917; IPR024607; Steryl-sulfatase (EC 3.1.6.2) (Arylsulfatase C) (ASC) (Steroid sulfatase) (Steryl-sulfate sulfohydrolase) Sts Mus musculus (Mouse) TR32890_c1_g2_i2 Q16629 SRSF7_HUMAN 3.00E-33 GO:0003723; GO:0031124; GO:0006406; GO:0000398; GO:0048025; GO:0005654; GO:0000166; GO:0006369; GO:0008270 Q9UBU9; Q7Z6E9; Q9JKL7; Q96SB4; P78362 "RNA binding; mRNA 3'-end processing; mRNA export from nucleus; mRNA splicing, via spliceosome; negative regulation of mRNA splicing, via spliceosome; nucleoplasm; nucleotide binding; termination of RNA polymerase II transcription; zinc ion binding" IPR012677; IPR000504; IPR001878; "Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)" SRSF7 SFRS7 Homo sapiens (Human) TR32890_c1_g2_i4 P92966 RSP41_ARATH 5.00E-07 GO:0003723; GO:0000166; GO:0005634 RNA binding; nucleotide binding; nucleus IPR012677; IPR000504; Arginine/serine-rich-splicing factor RSP41 RSP41 At5g52040 MSG15.12 Arabidopsis thaliana (Mouse-ear cress) TR32890_c1_g2_i8 Q16629 SRSF7_HUMAN 3.00E-33 GO:0003723; GO:0031124; GO:0006406; GO:0000398; GO:0048025; GO:0005654; GO:0000166; GO:0006369; GO:0008270 Q9UBU9; Q7Z6E9; Q9JKL7; Q96SB4; P78362 "RNA binding; mRNA 3'-end processing; mRNA export from nucleus; mRNA splicing, via spliceosome; negative regulation of mRNA splicing, via spliceosome; nucleoplasm; nucleotide binding; termination of RNA polymerase II transcription; zinc ion binding" IPR012677; IPR000504; IPR001878; "Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)" SRSF7 SFRS7 Homo sapiens (Human) TR32894_c0_g2_i1 Q03277 PO11_SCICO 3.00E-10 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis IPR005135; IPR000477; Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 (Retrovirus-related Pol polyprotein from type I retrotransposable element R1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] (Fragment) Sciara coprophila (Fungus gnat) TR32894_c0_g3_i1 P21329 RTJK_DROFU 2.00E-29 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) TR32895_c0_g1_i1 A7SG73 NADC_NEMVE 6.00E-123 GO:0009435; GO:0004514 NAD biosynthetic process; nicotinate-nucleotide diphosphorylase (carboxylating) activity IPR013785; IPR004393; IPR027277; IPR002638; IPR022412; Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1. Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) (Fragment) qprt v1g117116 Nematostella vectensis (Starlet sea anemone) TR32896_c3_g1_i2 Q9H7Z3 CN102_HUMAN 1.00E-22 Q15287 IPR013633; IPR011990; Protein NRDE2 homolog NRDE2 C14orf102 Homo sapiens (Human) TR32896_c5_g2_i1 Q80XC6 CN102_MOUSE 3.00E-20 IPR013633; IPR011990; Protein NRDE2 homolog Nrde2 Mus musculus (Mouse) TR32897_c0_g1_i2 Q3U5Q7 CMPK2_MOUSE 8.00E-33 GO:0005524; GO:0033862; GO:0071222; GO:0004127; GO:0005739; GO:0004550; GO:0009142; GO:0005634; GO:0006221 ATP binding; UMP kinase activity; cellular response to lipopolysaccharide; cytidylate kinase activity; mitochondrion; nucleoside diphosphate kinase activity; nucleoside triphosphate biosynthetic process; nucleus; pyrimidine nucleotide biosynthetic process IPR027417; IPR014505; "UMP-CMP kinase 2, mitochondrial (EC 2.7.4.14) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Thymidylate kinase LPS-inducible member) (TYKi)" Cmpk2 Tyki Mus musculus (Mouse) TR32898_c0_g1_i1 Q64591 DECR_RAT 9.00E-126 GO:0008670; GO:0006635; GO:0005739 "2,4-dienoyl-CoA reductase (NADPH) activity; fatty acid beta-oxidation; mitochondrion" IPR002347; IPR016040; "2,4-dienoyl-CoA reductase, mitochondrial (EC 1.3.1.34) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH])" Decr1 Decr Rattus norvegicus (Rat) TR32899_c3_g1_i1 O69669 EGTD_MYCTU 1.00E-25 GO:0052707; GO:0030745; GO:0052704; GO:0005886; GO:0008276 "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine; dimethylhistidine N-methyltransferase activity; ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine; plasma membrane; protein methyltransferase activity" IPR019257; IPR017804; Amino-acid biosynthesis; ergothioneine biosynthesis. Histidine-specific methyltransferase EgtD (EC 2.1.1.44) (Histidine-alpha-N-methyltransferase) egtD Rv3701c MT3804 Mycobacterium tuberculosis TR32899_c3_g1_i2 O94632 MU158_SCHPO 2.00E-07 GO:0005509; GO:0005829; GO:0005788; GO:0007126; GO:0005634 calcium ion binding; cytosol; endoplasmic reticulum lumen; meiosis; nucleus IPR016187; IPR005532; IPR019257; IPR017805; Meiotically up-regulated gene 158 protein mug158 SPBC1604.01 SPBC1677.01c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR32899_c4_g1_i6 Q9V0D5 MDH_PYRAB 3.00E-65 GO:0030060; GO:0005737; GO:0006099 L-malate dehydrogenase activity; cytoplasm; tricarboxylic acid cycle IPR003767; Malate dehydrogenase (EC 1.1.1.37) mdh PYRAB08550 PAB1791 Pyrococcus abyssi (strain GE5 / Orsay) TR32901_c1_g1_i1 O18806 FA8_CANFA 2.00E-25 GO:0006953; GO:0007155; GO:0005507; GO:0005615; GO:0016491; GO:0030168 acute-phase response; cell adhesion; copper ion binding; extracellular space; oxidoreductase activity; platelet activation IPR000421; IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; IPR024715; IPR008979; Coagulation factor VIII (Procoagulant component) F8 Canis familiaris (Dog) (Canis lupus familiaris) TR32901_c2_g1_i1 P48744 NDP_MOUSE 5.00E-06 GO:0060070; GO:0009986; GO:0005125; GO:0031012; GO:0035426; GO:0005615; GO:0001890; GO:0051091; GO:0045893; GO:0061299 "canonical Wnt receptor signaling pathway; cell surface; cytokine activity; extracellular matrix; extracellular matrix-cell signaling; extracellular space; placenta development; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; retina vasculature morphogenesis in camera-type eye" IPR006207; IPR004133; IPR003064; Norrin (Norrie disease protein homolog) Ndp Ndph Mus musculus (Mouse) TR32901_c2_g2_i1 Q28833 VWF_PIG 8.00E-13 GO:0033093; GO:0031589; GO:0051087; GO:0005518; GO:0005783; GO:0031012; GO:0005576; GO:0001948; GO:0019865; GO:0005178; GO:0030168; GO:0002020; GO:0047485; GO:0042803; GO:0051260; GO:0005578 Weibel-Palade body; cell-substrate adhesion; chaperone binding; collagen binding; endoplasmic reticulum; extracellular matrix; extracellular region; glycoprotein binding; immunoglobulin binding; integrin binding; platelet activation; protease binding; protein N-terminus binding; protein homodimerization activity; protein homooligomerization; proteinaceous extracellular matrix IPR006207; IPR000742; IPR002919; IPR014853; IPR002035; IPR001007; IPR001846; von Willebrand factor (vWF) (Fragment) VWF F8VWF Sus scrofa (Pig) TR32903_c0_g1_i2 O19094 OCTC_BOVIN 2.00E-117 GO:0008458; GO:0006635; GO:0006091; GO:0051791; GO:0005777; GO:0006810 carnitine O-octanoyltransferase activity; fatty acid beta-oxidation; generation of precursor metabolites and energy; medium-chain fatty acid metabolic process; peroxisome; transport IPR000542; Lipid metabolism; fatty acid beta-oxidation. Peroxisomal carnitine O-octanoyltransferase (COT) (EC 2.3.1.137) CROT COT Bos taurus (Bovine) TR32903_c1_g1_i1 O19094 OCTC_BOVIN 4.00E-67 GO:0008458; GO:0006635; GO:0006091; GO:0051791; GO:0005777; GO:0006810 carnitine O-octanoyltransferase activity; fatty acid beta-oxidation; generation of precursor metabolites and energy; medium-chain fatty acid metabolic process; peroxisome; transport IPR000542; Lipid metabolism; fatty acid beta-oxidation. Peroxisomal carnitine O-octanoyltransferase (COT) (EC 2.3.1.137) CROT COT Bos taurus (Bovine) TR32903_c1_g1_i2 Q8BGD5 CPT1C_MOUSE 8.00E-21 GO:0032281; GO:0004095; GO:0030054; GO:0006635; GO:0005741; GO:0005739; GO:0045202 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; carnitine O-palmitoyltransferase activity; cell junction; fatty acid beta-oxidation; mitochondrial outer membrane; mitochondrion; synapse IPR000542; Lipid metabolism; fatty acid beta-oxidation. "Carnitine O-palmitoyltransferase 1, brain isoform (CPT1-B) (EC 2.3.1.21) (CPT IC) (Carnitine O-palmitoyltransferase I, brain isoform) (CPTI-B) (Carnitine palmitoyltransferase 1C)" Cpt1c Mus musculus (Mouse) TR32904_c0_g2_i1 Q2TBT8 RN151_BOVIN 5.00E-06 GO:0005634; GO:0004842; GO:0008270 nucleus; ubiquitin-protein ligase activity; zinc ion binding IPR013323; IPR008974; IPR001841; IPR013083; IPR017907; IPR013010; IPR001293; RING finger protein 151 RNF151 Bos taurus (Bovine) TR32905_c7_g3_i1 E9QBI7 OMA1_DANRE 2.00E-81 GO:0002024; GO:0097009; GO:0006006; GO:0016021; GO:0006629; GO:0046872; GO:0004222; GO:0006515; GO:0005743; GO:0031966; GO:0010637; GO:0006950 diet induced thermogenesis; energy homeostasis; glucose metabolic process; integral to membrane; lipid metabolic process; metal ion binding; metalloendopeptidase activity; misfolded or incompletely synthesized protein catabolic process; mitochondrial inner membrane; mitochondrial membrane; negative regulation of mitochondrial fusion; response to stress IPR001915; "Metalloendopeptidase OMA1, mitochondrial (EC 3.4.24.-) (Overlapping with the m-AAA protease 1 homolog)" oma1 si:ch73-215a11.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR32905_c8_g1_i1 P43243 MATR3_HUMAN 5.00E-11 GO:0003723; GO:0005637; GO:0016363; GO:0000166; GO:0005198; GO:0008270 P22736 RNA binding; nuclear inner membrane; nuclear matrix; nucleotide binding; structural molecule activity; zinc ion binding IPR012677; IPR000504; IPR015880; IPR000690; IPR003604; Matrin-3 MATR3 KIAA0723 Homo sapiens (Human) TR32906_c1_g2_i1 Q6PJ21 SPSB3_HUMAN 1.00E-82 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR001870; IPR008985; IPR001496; IPR003877; Protein modification; protein ubiquitination. SPRY domain-containing SOCS box protein 3 (SSB-3) SPSB3 C16orf31 SSB3 Homo sapiens (Human) TR32906_c1_g2_i2 Q6PJ21 SPSB3_HUMAN 2.00E-82 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR001870; IPR008985; IPR001496; IPR003877; Protein modification; protein ubiquitination. SPRY domain-containing SOCS box protein 3 (SSB-3) SPSB3 C16orf31 SSB3 Homo sapiens (Human) TR32906_c1_g2_i3 Q3MHZ2 SPSB3_BOVIN 9.00E-81 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR001870; IPR008985; IPR001496; IPR003877; Protein modification; protein ubiquitination. SPRY domain-containing SOCS box protein 3 (SSB-3) SPSB3 SSB3 Bos taurus (Bovine) TR32907_c1_g1_i1 Q91VP7 TM101_MOUSE 3.00E-17 GO:0016021; GO:0043123; GO:0004871 integral to membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity Transmembrane protein 101 Tmem101 Mus musculus (Mouse) TR32908_c5_g1_i1 Q80UG2 PLXA4_MOUSE 1.00E-47 GO:0021960; GO:0021793; GO:0021610; GO:0021615; GO:0016021; GO:0005622; GO:0005886; GO:0021784; GO:0048841; GO:0050923; GO:0017154; GO:0048485; GO:0021636; GO:0021644 O35464 anterior commissure morphogenesis; chemorepulsion of branchiomotor axon; facial nerve morphogenesis; glossopharyngeal nerve morphogenesis; integral to membrane; intracellular; plasma membrane; postganglionic parasympathetic nervous system development; regulation of axon extension involved in axon guidance; regulation of negative chemotaxis; semaphorin receptor activity; sympathetic nervous system development; trigeminal nerve morphogenesis; vagus nerve morphogenesis IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A4 Plxna4 Kiaa1550 Mus musculus (Mouse) TR32910_c0_g1_i1 Q63931 CCKAR_CAVPO 4.00E-11 GO:0004951; GO:0038188; GO:0016021; GO:0005886 cholecystokinin receptor activity; cholecystokinin signaling pathway; integral to membrane; plasma membrane IPR009126; IPR000596; IPR015276; IPR000276; IPR017452; Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR Cavia porcellus (Guinea pig) TR32913_c0_g2_i1 Q9NPF2 CHSTB_HUMAN 6.00E-72 GO:0000139; GO:0001537; GO:0050659; GO:0016051; GO:0005975; GO:0002063; GO:0047756; GO:0030206; GO:0048589; GO:0042733; GO:0048703; GO:0016021; GO:0043066; GO:0030512; GO:0033037; GO:0036342; GO:0009791; GO:0042127; GO:0007585 Golgi membrane; N-acetylgalactosamine 4-O-sulfotransferase activity; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity; carbohydrate biosynthetic process; carbohydrate metabolic process; chondrocyte development; chondroitin 4-sulfotransferase activity; chondroitin sulfate biosynthetic process; developmental growth; embryonic digit morphogenesis; embryonic viscerocranium morphogenesis; integral to membrane; negative regulation of apoptotic process; negative regulation of transforming growth factor beta receptor signaling pathway; polysaccharide localization; post-anal tail morphogenesis; post-embryonic development; regulation of cell proliferation; respiratory gaseous exchange IPR018011; IPR005331; Carbohydrate sulfotransferase 11 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 1) (Chondroitin 4-sulfotransferase 1) (C4S-1) (C4ST-1) (C4ST1) CHST11 Homo sapiens (Human) TR32915_c0_g1_i1 Q5RCE2 STT3A_PONAB 0 GO:0043686; GO:0004579; GO:0016021; GO:0008250; GO:0018279 co-translational protein modification; dolichyl-diphosphooligosaccharide-protein glycotransferase activity; integral to membrane; oligosaccharyltransferase complex; protein N-linked glycosylation via asparagine IPR003674; Protein modification; protein glycosylation. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (Oligosaccharyl transferase subunit STT3A) (STT3-A) (EC 2.4.99.18) STT3A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR32917_c0_g3_i1 Q5W111 SPRY7_HUMAN 1.00E-79 IPR001870; IPR008985; IPR018355; IPR003877; SPRY domain-containing protein 7 (Chronic lymphocytic leukemia deletion region gene 6 protein) (CLL deletion region gene 6 protein) SPRYD7 C13orf1 CLLD6 Homo sapiens (Human) TR32918_c0_g1_i1 Q9BRZ2 TRI56_HUMAN 9.00E-19 GO:0005829; GO:0051607; GO:0032608; GO:0032481; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytosol; defense response to virus; interferon-beta production; positive regulation of type I interferon production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) TR32919_c0_g1_i1 P59890 H2A_HIPHI 5.00E-06 GO:0003677; GO:0042742; GO:0005576; GO:0000786; GO:0006334; GO:0005634 DNA binding; defense response to bacterium; extracellular region; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR002119; Histone H2A [Cleaved into: Hipposin] (Fragment) Hippoglossus hippoglossus (Atlantic halibut) (Pleuronectes hippoglossus) TR32919_c0_g1_i2 Q6YNC8 H2AZ_SHEEP 3.00E-69 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR002119; Histone H2A.Z (H2A/z) H2AFZ Ovis aries (Sheep) TR32920_c1_g1_i1 Q9D7A8 ARMC1_MOUSE 6.00E-35 GO:0046872; GO:0030001; GO:0005739 metal ion binding; metal ion transport; mitochondrion IPR011989; IPR016024; IPR000225; IPR006121; IPR016617; Armadillo repeat-containing protein 1 Armc1 Mus musculus (Mouse) TR32924_c0_g2_i1 Q6DBR9 KXDL1_DANRE 4.00E-27 GO:0016192 vesicle-mediated transport IPR019371; KxDL motif-containing protein 1 kxd1 zgc:91862 Danio rerio (Zebrafish) (Brachydanio rerio) TR32925_c3_g2_i3 A4FU69 EFCB5_HUMAN 6.00E-06 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR003018; EF-hand calcium-binding domain-containing protein 5 EFCAB5 Homo sapiens (Human) TR32927_c1_g1_i1 Q969Q5 RAB24_HUMAN 7.00E-59 GO:0005525; GO:0005776; GO:0006914; GO:0005829; GO:0016020; GO:0005739; GO:0015031; GO:0007264 GTP binding; autophagic vacuole; autophagy; cytosol; membrane; mitochondrion; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-24 RAB24 Homo sapiens (Human) TR32928_c0_g1_i1 Q86XN7 PRSR1_HUMAN 8.00E-06 IPR028011; Proline and serine-rich protein 1 PROSER1 C13orf23 KIAA2032 Homo sapiens (Human) TR32930_c0_g1_i1 Q8C811 S35E2_MOUSE 1.00E-58 GO:0016021 integral to membrane IPR000620; IPR004853; Solute carrier family 35 member E2 Slc35e2 Mus musculus (Mouse) TR32932_c1_g1_i1 A0KKE6 SELU_AERHH 4.00E-38 GO:0043828; GO:0070329 tRNA 2-selenouridine synthase activity; tRNA seleno-modification IPR027417; IPR001763; IPR017582; tRNA 2-selenouridine synthase (EC 2.9.1.-) (Selenophosphate-dependent tRNA 2-selenouridine synthase) selU AHA_2223 Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) TR32933_c0_g1_i1 Q8TD35 CT201_HUMAN 3.00E-08 Uncharacterized protein C20orf201 C20orf201 Homo sapiens (Human) TR32935_c0_g1_i1 O35490 BHMT1_MOUSE 3.00E-52 GO:0006579; GO:0047150; GO:0005737; GO:0008898; GO:0009086; GO:0008270 amino-acid betaine catabolic process; betaine-homocysteine S-methyltransferase activity; cytoplasm; homocysteine S-methyltransferase activity; methionine biosynthetic process; zinc ion binding IPR017226; IPR003726; Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. Betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5) Bhmt Mus musculus (Mouse) TR32936_c1_g1_i1 Q9QW30 NOTC2_RAT 5.00E-10 GO:0007219; GO:0005509; GO:0007050; GO:0001709; GO:0016049; GO:0009986; GO:0005829; GO:0005576; GO:0005887; GO:0008285; GO:0005634; GO:0009887; GO:0046579; GO:0004872; GO:0050793; GO:0006355; GO:0042246; GO:0006351 "Notch signaling pathway; calcium ion binding; cell cycle arrest; cell fate determination; cell growth; cell surface; cytosol; extracellular region; integral to plasma membrane; negative regulation of cell proliferation; nucleus; organ morphogenesis; positive regulation of Ras protein signal transduction; receptor activity; regulation of developmental process; regulation of transcription, DNA-dependent; tissue regeneration; transcription, DNA-dependent" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022336; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 2 (Notch 2) [Cleaved into: Notch 2 extracellular truncation; Notch 2 intracellular domain] Notch2 Rattus norvegicus (Rat) TR32936_c1_g1_i2 Q8VHS2 CRUM1_MOUSE 3.00E-11 GO:0005509; GO:0042462; GO:0016021; GO:0005902; GO:0005886; GO:0007009 calcium ion binding; eye photoreceptor cell development; integral to membrane; microvillus; plasma membrane; plasma membrane organization IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protein crumbs homolog 1 Crb1 Mus musculus (Mouse) TR32937_c0_g2_i1 O60688 YPEL1_HUMAN 3.00E-69 GO:0051898; GO:0005634; GO:0031641 negative regulation of protein kinase B signaling cascade; nucleus; regulation of myelination IPR004910; Protein yippee-like 1 YPEL1 FKSG3 Homo sapiens (Human) TR32939_c1_g1_i1 Q96M34 CC030_HUMAN 3.00E-08 IPR003117; Uncharacterized protein C3orf30 C3orf30 Homo sapiens (Human) TR32940_c3_g2_i1 Q8VCR7 ABHEB_MOUSE 2.00E-30 GO:0005737; GO:0016787; GO:0005634 cytoplasm; hydrolase activity; nucleus IPR026764; Alpha/beta hydrolase domain-containing protein 14B (Abhydrolase domain-containing protein 14B) (EC 3.-.-.-) (CCG1-interacting factor B) Abhd14b Cib Mus musculus (Mouse) TR32940_c3_g2_i2 Q922Q6 ABHEA_MOUSE 2.00E-28 GO:0005737; GO:0016787; GO:0016021 cytoplasm; hydrolase activity; integral to membrane Alpha/beta hydrolase domain-containing protein 14A (Abhydrolase domain-containing protein 14A) (EC 3.-.-.-) (Down-regulated in Zic-1-mutant protein) Abhd14a Dorz1 Mus musculus (Mouse) TR32941_c1_g1_i1 Q9NSG2 CA112_HUMAN 4.00E-22 IPR027902; Uncharacterized protein C1orf112 C1orf112 Homo sapiens (Human) TR32944_c0_g1_i2 Q8N8Q1 C56D1_HUMAN 2.00E-35 GO:0016021; GO:0046872; GO:0055114 integral to membrane; metal ion binding; oxidation-reduction process IPR006593; IPR004877; Cytochrome b561 domain-containing protein 1 CYB561D1 Homo sapiens (Human) TR32944_c0_g1_i3 Q641Y1 C56D2_RAT 3.00E-07 GO:0016021; GO:0046872; GO:0055114 integral to membrane; metal ion binding; oxidation-reduction process IPR006593; IPR004877; Cytochrome b561 domain-containing protein 2 Cyb561d2 Rattus norvegicus (Rat) TR32946_c0_g1_i1 A8WIP6 CDK20_DANRE 0 GO:0005524; GO:0051301; GO:0005929; GO:0060271; GO:0004693; GO:0005737; GO:0007275; GO:0005634 ATP binding; cell division; cilium; cilium morphogenesis; cyclin-dependent protein serine/threonine kinase activity; cytoplasm; multicellular organismal development; nucleus IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 20 (EC 2.7.11.22) (Cell cycle-related kinase) (Cell division protein kinase 20) cdk20 ccrk si:dkeyp-77f7.1 zgc:101530 Danio rerio (Zebrafish) (Brachydanio rerio) TR3295_c0_g1_i1 Q8CHG5 K0317_MOUSE 2.00E-26 GO:0006915; GO:0005829; GO:0016021; GO:0043066; GO:0005634; GO:0042787; GO:0004842 apoptotic process; cytosol; integral to membrane; negative regulation of apoptotic process; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR001298; IPR017868; IPR000569; IPR013783; IPR014756; Protein modification; protein ubiquitination. Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 6.3.2.-) Arel1 Kiaa0317 Mus musculus (Mouse) TR32951_c1_g1_i1 B5XB24 EMC4_SALSA 3.00E-50 GO:0072546 ER membrane protein complex IPR009445; ER membrane protein complex subunit 4 (Transmembrane protein 85) emc4 tmem85 Salmo salar (Atlantic salmon) TR32951_c1_g1_i3 B5XB24 EMC4_SALSA 9.00E-50 GO:0072546 ER membrane protein complex IPR009445; ER membrane protein complex subunit 4 (Transmembrane protein 85) emc4 tmem85 Salmo salar (Atlantic salmon) TR32952_c5_g1_i1 Q18905 CGP1_CAEEL 2.00E-71 GO:0005525; GO:0006184; GO:0003924 GTP binding; GTP catabolic process; GTPase activity IPR000795; IPR027417; IPR009000; IPR009001; IPR004161; IPR004160; GTP-binding protein cgp-1 cgp-1 Y38C9A.2 Caenorhabditis elegans TR32952_c5_g1_i3 Q9BX10 GTPB2_HUMAN 6.00E-113 GO:0005525; GO:0006184; GO:0003924 O60341; O14744; Q96LA8; O43463 GTP binding; GTP catabolic process; GTPase activity IPR000795; IPR027417; IPR009000; IPR009001; IPR004160; GTP-binding protein 2 GTPBP2 Homo sapiens (Human) TR32952_c5_g1_i4 P35021 EF1A_SULSO 6.00E-06 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; translation elongation factor activity IPR000795; IPR027417; IPR005225; IPR009000; IPR009001; IPR004539; IPR004161; IPR004160; Elongation factor 1-alpha (EF-1-alpha) (Elongation factor Tu) (EF-Tu) tuf tef1 SSO0216 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) TR32956_c0_g1_i1 Q95ND5 CASP3_PIG 3.00E-10 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Sus scrofa (Pig) TR32956_c0_g1_i3 P97864 CASP7_MOUSE 5.00E-16 GO:0004190; GO:0097153; GO:0005737; GO:0097194; GO:0007507; GO:0005634; GO:0043525; GO:0016485; GO:0006508; GO:0001836; GO:0009411 P11103; P62270 aspartic-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cytoplasm; execution phase of apoptosis; heart development; nucleus; positive regulation of neuron apoptotic process; protein processing; proteolysis; release of cytochrome c from mitochondria; response to UV IPR015471; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; "Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11; Caspase-7, N-terminally processed]" Casp7 Lice2 Mch3 Mus musculus (Mouse) TR32958_c2_g1_i2 Q5R613 SNX6_PONAB 0 GO:0007154; GO:0030659; GO:0031901; GO:0006886; GO:0005634; GO:0035091; GO:0042147 "cell communication; cytoplasmic vesicle membrane; early endosome membrane; intracellular protein transport; nucleus; phosphatidylinositol binding; retrograde transport, endosome to Golgi" IPR027267; IPR001683; IPR014637; IPR015404; "Sorting nexin-6 [Cleaved into: Sorting nexin-6, N-terminally processed]" SNX6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR32960_c0_g1_i1 P58751 RELN_RAT 3.00E-67 GO:0030424; GO:0007411; GO:0007155; GO:0071549; GO:0021800; GO:0005737; GO:0030425; GO:0021542; GO:0005615; GO:0010001; GO:0021854; GO:0007626; GO:0007613; GO:0046872; GO:0007494; GO:0001764; GO:0021769; GO:0018108; GO:0043204; GO:0045860; GO:0051057; GO:0004712; GO:0005578; GO:0006508; GO:0043200; GO:0048678; GO:0051412; GO:0042493; GO:0051602; GO:0045471; GO:0070542; GO:0017085; GO:0010226; GO:0009612; GO:0048265; GO:0032570; GO:0008236; GO:0035176; GO:0021511 axon; axon guidance; cell adhesion; cellular response to dexamethasone stimulus; cerebral cortex tangential migration; cytoplasm; dendrite; dentate gyrus development; extracellular space; glial cell differentiation; hypothalamus development; locomotory behavior; memory; metal ion binding; midgut development; neuron migration; orbitofrontal cortex development; peptidyl-tyrosine phosphorylation; perikaryon; positive regulation of protein kinase activity; positive regulation of small GTPase mediated signal transduction; protein serine/threonine/tyrosine kinase activity; proteinaceous extracellular matrix; proteolysis; response to amino acid stimulus; response to axon injury; response to corticosterone stimulus; response to drug; response to electrical stimulus; response to ethanol; response to fatty acid; response to insecticide; response to lithium ion; response to mechanical stimulus; response to pain; response to progesterone stimulus; serine-type peptidase activity; social behavior; spinal cord patterning IPR000742; IPR013032; IPR002861; IPR011040; Reelin (EC 3.4.21.-) Reln Rattus norvegicus (Rat) TR32960_c1_g1_i1 P78509 RELN_HUMAN 6.00E-33 GO:0097114; GO:0008306; GO:0007411; GO:0007155; GO:0021800; GO:0005737; GO:0030425; GO:0016358; GO:0005615; GO:0010001; GO:0021766; GO:0007616; GO:0046872; GO:0001764; GO:0018108; GO:0032793; GO:0032008; GO:2000969; GO:0061003; GO:2000463; GO:1900273; GO:0010976; GO:0014068; GO:0061098; GO:0051057; GO:0090129; GO:0051968; GO:0097119; GO:0004712; GO:0005578; GO:0006508; GO:0097120; GO:0038026; GO:2000310; GO:0050795; GO:0048265; GO:0008236; GO:0021511; GO:0021517; GO:0070326 "N-methyl-D-aspartate receptor clustering; associative learning; axon guidance; cell adhesion; cerebral cortex tangential migration; cytoplasm; dendrite; dendrite development; extracellular space; glial cell differentiation; hippocampus development; long-term memory; metal ion binding; neuron migration; peptidyl-tyrosine phosphorylation; positive regulation of CREB transcription factor activity; positive regulation of TOR signaling cascade; positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; positive regulation of dendritic spine morphogenesis; positive regulation of excitatory postsynaptic membrane potential; positive regulation of long-term synaptic potentiation; positive regulation of neuron projection development; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of protein tyrosine kinase activity; positive regulation of small GTPase mediated signal transduction; positive regulation of synapse maturation; positive regulation of synaptic transmission, glutamatergic; postsynaptic density protein 95 clustering; protein serine/threonine/tyrosine kinase activity; proteinaceous extracellular matrix; proteolysis; receptor localization to synapse; reelin-mediated signaling pathway; regulation of N-methyl-D-aspartate selective glutamate receptor activity; regulation of behavior; response to pain; serine-type peptidase activity; spinal cord patterning; ventral spinal cord development; very-low-density lipoprotein particle receptor binding" IPR000742; IPR013032; IPR002861; IPR011040; Reelin (EC 3.4.21.-) RELN Homo sapiens (Human) TR32963_c0_g2_i1 O43301 HS12A_HUMAN 1.00E-49 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR32964_c7_g1_i1 Q9QXM0 ABHD2_MOUSE 3.00E-122 GO:0004091; GO:0016021; GO:0030336; GO:0009611 carboxylesterase activity; integral to membrane; negative regulation of cell migration; response to wounding IPR012020; IPR000073; IPR000952; Abhydrolase domain-containing protein 2 (EC 3.1.1.-) (Lung alpha/beta hydrolase 2) (MmLABH2) Abhd2 Labh-2 Labh2 Mus musculus (Mouse) TR32968_c1_g1_i1 Q90352 AVT_CATCO 9.00E-08 GO:0016021; GO:0005886; GO:0005000 integral to membrane; plasma membrane; vasopressin receptor activity IPR015076; IPR000276; IPR017452; IPR001817; IPR001224; [Arg8]-vasotocin receptor (AVT) Catostomus commersonii (White sucker) TR32971_c1_g1_i1 Q7T3T8 ZAR1_DANRE 2.00E-23 GO:0005737; GO:0007275 cytoplasm; multicellular organismal development IPR026775; IPR027377; Zygote arrest protein 1 (Oocyte-specific maternal effect factor) zar1 Danio rerio (Zebrafish) (Brachydanio rerio) TR32972_c0_g2_i1 Q8WU76 SCFD2_HUMAN 5.00E-54 GO:0015031; GO:0006904 protein transport; vesicle docking involved in exocytosis IPR027482; IPR001619; Sec1 family domain-containing protein 2 (Syntaxin-binding protein 1-like 1) SCFD2 STXBP1L1 Homo sapiens (Human) TR32975_c1_g2_i1 Q8VDM6 HNRL1_MOUSE 1.00E-153 GO:0003723; GO:0005634; GO:0006355; GO:0030529; GO:0006351 "RNA binding; nucleus; regulation of transcription, DNA-dependent; ribonucleoprotein complex; transcription, DNA-dependent" IPR001870; IPR008985; IPR027417; IPR003034; IPR018355; IPR003877; Heterogeneous nuclear ribonucleoprotein U-like protein 1 Hnrnpul1 Hnrpul1 Mus musculus (Mouse) TR32975_c1_g2_i2 Q0IIK5 DDX1_BOVIN 7.00E-16 GO:0005524; GO:0008026; GO:0003677; GO:0032508; GO:0033677; GO:0003682; GO:0071920; GO:0010494; GO:0006302; GO:0003725; GO:0004527; GO:0006397; GO:0007275; GO:0004518; GO:0008143; GO:0006355; GO:0043330; GO:0009615; GO:0072669; GO:0003712; GO:0006351 "ATP binding; ATP-dependent helicase activity; DNA binding; DNA duplex unwinding; DNA/RNA helicase activity; chromatin binding; cleavage body; cytoplasmic stress granule; double-strand break repair; double-stranded RNA binding; exonuclease activity; mRNA processing; multicellular organismal development; nuclease activity; poly(A) RNA binding; regulation of transcription, DNA-dependent; response to exogenous dsRNA; response to virus; tRNA-splicing ligase complex; transcription cofactor activity; transcription, DNA-dependent" IPR001870; IPR008985; IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; IPR018355; IPR003877; ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) DDX1 Bos taurus (Bovine) TR32976_c1_g2_i1 Q5ZIH9 CC019_CHICK 7.00E-74 IPR025066; Coiled-coil domain-containing protein 174 CCDC174 RCJMB04_26a16 Gallus gallus (Chicken) TR32976_c1_g2_i2 Q3U155 CC019_MOUSE 5.00E-71 IPR025066; Coiled-coil domain-containing protein 174 Ccdc174 Mus musculus (Mouse) TR32979_c3_g1_i1 Q8BHF7 PGPS1_MOUSE 2.00E-87 GO:0005524; GO:0008444; GO:0032049; GO:0046339; GO:0005783; GO:0005739 ATP binding; CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity; cardiolipin biosynthetic process; diacylglycerol metabolic process; endoplasmic reticulum; mitochondrion IPR016270; IPR001736; Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2. "CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (EC 2.7.8.5) (Phosphatidylglycerophosphate synthase 1) (PGP synthase 1) (Silencer-associated factor)" Pgs1 Saf Mus musculus (Mouse) TR32980_c0_g1_i1 Q3U564 DCP1B_MOUSE 1.00E-21 GO:0005737; GO:0016787; GO:0000184; GO:0005634 "cytoplasm; hydrolase activity; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus" IPR010334; IPR011993; mRNA-decapping enzyme 1B (EC 3.-.-.-) Dcp1b Mus musculus (Mouse) TR32981_c4_g1_i1 P41437 IAP3_NPVOP 1.00E-23 GO:0006915; GO:0016874; GO:0039648; GO:0008270 apoptotic process; ligase activity; modulation by virus of host protein ubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; E3 ubiquitin-protein ligase IAP-3 (EC 6.3.2.-) (IAP-3) IAP3 IAP ORF35 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) TR32981_c4_g1_i2 Q13490 BIRC2_HUMAN 6.00E-33 GO:0035631; GO:0038061; GO:0035666; GO:0007166; GO:0006921; GO:0005829; GO:0045087; GO:0009898; GO:0070266; GO:0043066; GO:0005634; GO:0001890; GO:0043123; GO:0043161; GO:0000209; GO:0039535; GO:0051726; GO:0045595; GO:0042127; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0006355; GO:0034138; GO:0034142; GO:0003713; GO:0006351; GO:0004842; GO:0008270 P55210; Q9NR28; P63000; Q13546; O43353; Q9Y572; P57078; Q9NP84; Q12933 "CD40 receptor complex; NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; cell surface receptor signaling pathway; cellular component disassembly involved in execution phase of apoptosis; cytosol; innate immune response; internal side of plasma membrane; necroptosis; negative regulation of apoptotic process; nucleus; placenta development; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of RIG-I signaling pathway; regulation of cell cycle; regulation of cell differentiation; regulation of cell proliferation; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; regulation of transcription, DNA-dependent; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (IAP-2) (hIAP-2) (hIAP2) (RING finger protein 48) (TNFR2-TRAF-signaling complex protein 2) BIRC2 API1 IAP2 MIHB RNF48 Homo sapiens (Human) TR32981_c5_g1_i1 Q8BM54 MYLIP_MOUSE 6.00E-08 GO:0006928; GO:0042632; GO:0005737; GO:0005856; GO:0019898; GO:0010989; GO:0007399; GO:0005886; GO:0045732; GO:0031648; GO:0042787; GO:0032803; GO:0055098; GO:0004842; GO:0008270 cellular component movement; cholesterol homeostasis; cytoplasm; cytoskeleton; extrinsic to membrane; negative regulation of low-density lipoprotein particle clearance; nervous system development; plasma membrane; positive regulation of protein catabolic process; protein destabilization; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of low-density lipoprotein particle receptor catabolic process; response to low-density lipoprotein particle stimulus; ubiquitin-protein ligase activity; zinc ion binding IPR019749; IPR019750; IPR000798; IPR014352; IPR019748; IPR000299; IPR018979; IPR011993; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MYLIP (EC 6.3.2.-) (Inducible degrader of the LDL-receptor) (Idol) (Myosin regulatory light chain-interacting protein) (MIR) Mylip Mus musculus (Mouse) TR32981_c5_g2_i2 Q95M71 BIRC8_GORGO 1.00E-38 GO:0006915; GO:0005737; GO:0008270 apoptotic process; cytoplasm; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis-like protein 2) (IAP-like protein 2) (ILP-2) BIRC8 ILP2 Gorilla gorilla gorilla (Lowland gorilla) TR32982_c5_g1_i3 Q14134 TRI29_HUMAN 2.00E-06 GO:0005737; GO:1900181; GO:0000122; GO:0003700; GO:0006366; GO:0008270 O15169; O14641; Q96CN9; P49841 cytoplasm; negative regulation of protein localization to nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; zinc ion binding IPR000315; Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein) TRIM29 ATDC Homo sapiens (Human) TR32985_c1_g1_i1 Q9EP71 RAI14_MOUSE 8.00E-08 GO:0005938; GO:0005856; GO:0005739; GO:0005634 cell cortex; cytoskeleton; mitochondrion; nucleus IPR002110; IPR020683; Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) (p125) Rai14 Kiaa1334 Norpeg Mus musculus (Mouse) TR32985_c1_g2_i1 Q02357 ANK1_MOUSE 1.00E-17 GO:0030863; GO:0048821; GO:0016020; GO:0015672; GO:0006779; GO:0016529; GO:0007165; GO:0014731 cortical cytoskeleton; erythrocyte development; membrane; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; sarcoplasmic reticulum; signal transduction; spectrin-associated cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) TR3299_c0_g1_i1 Q02833 RASF7_HUMAN 5.00E-08 GO:0003677; GO:0006915; GO:0005737; GO:0005815; GO:0005634; GO:0006355; GO:0007165 "DNA binding; apoptotic process; cytoplasm; microtubule organizing center; nucleus; regulation of transcription, DNA-dependent; signal transduction" IPR000159; Ras association domain-containing protein 7 (HRAS1-related cluster protein 1) RASSF7 C11orf13 HRC1 Homo sapiens (Human) TR32990_c0_g1_i1 Q2KHX8 RCL1_BOVIN 1.00E-81 GO:0006396; GO:0003824; GO:0005730; GO:0042254 RNA processing; catalytic activity; nucleolus; ribosome biogenesis IPR013791; IPR023797; IPR000228; IPR016443; IPR020719; IPR013792; RNA 3'-terminal phosphate cyclase-like protein RCL1 Bos taurus (Bovine) TR32992_c0_g2_i1 Q96LK0 CEP19_HUMAN 9.00E-41 GO:0005814; GO:0000922 centriole; spindle pole Centrosomal protein of 19 kDa (Cep19) CEP19 C3orf34 HSD5 Homo sapiens (Human) TR32993_c0_g1_i1 Q9WTN3 SRBP1_MOUSE 1.00E-166 GO:0012507; GO:0000139; GO:0007568; GO:0009267; GO:0008203; GO:0003682; GO:0005789; GO:0008286; GO:0016021; GO:0008610; GO:0030324; GO:0046676; GO:0000122; GO:0005654; GO:0045542; GO:0045723; GO:0031065; GO:0045944; GO:0045893; GO:0010867; GO:0043234; GO:0003062; GO:0051591; GO:0042493; GO:0070542; GO:0032094; GO:0033762; GO:0009749; GO:0032570; GO:0032526; GO:0043565; GO:0003700; GO:0032810; GO:0044212; GO:0006351 Q923E4 "ER to Golgi transport vesicle membrane; Golgi membrane; aging; cellular response to starvation; cholesterol metabolic process; chromatin binding; endoplasmic reticulum membrane; insulin receptor signaling pathway; integral to membrane; lipid biosynthetic process; lung development; negative regulation of insulin secretion; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; positive regulation of cholesterol biosynthetic process; positive regulation of fatty acid biosynthetic process; positive regulation of histone deacetylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of triglyceride biosynthetic process; protein complex; regulation of heart rate by chemical signal; response to cAMP; response to drug; response to fatty acid; response to food; response to glucagon stimulus; response to glucose stimulus; response to progesterone stimulus; response to retinoic acid; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sterol response element binding; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR011598; Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1] Srebf1 Srebp1 Mus musculus (Mouse) TR32994_c1_g1_i1 Q55E58 PATS1_DICDI 3.00E-06 GO:0005524; GO:0005525; GO:0042641; GO:0000281; GO:0004721; GO:0006470; GO:0004674; GO:0007264 ATP binding; GTP binding; actomyosin; mitotic cytokinesis; phosphoprotein phosphatase activity; protein dephosphorylation; protein serine/threonine kinase activity; small GTPase mediated signal transduction IPR011009; IPR001611; IPR013684; IPR010569; IPR017906; IPR027417; IPR000719; IPR011047; IPR020859; IPR001245; IPR008271; IPR005225; IPR001806; IPR015943; IPR001680; IPR017986; Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) TR32995_c0_g1_i1 P08548 LIN1_NYCCO 1.00E-24 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR32995_c0_g1_i2 P11369 POL2_MOUSE 2.00E-23 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR013544; IPR005135; IPR000477; Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element-1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] Pol Gm17492 Mus musculus (Mouse) TR32995_c0_g1_i3 P08548 LIN1_NYCCO 7.00E-24 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR32995_c0_g1_i8 P08548 LIN1_NYCCO 8.00E-24 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR32996_c0_g1_i1 Q9Z2H4 LGR4_RAT 3.00E-10 GO:0007186; GO:0016055; GO:0030282; GO:0046849; GO:0045087; GO:0005887; GO:0050710; GO:0034122; GO:0001649; GO:0090263; GO:0007283; GO:0004888 G-protein coupled receptor signaling pathway; Wnt receptor signaling pathway; bone mineralization; bone remodeling; innate immune response; integral to plasma membrane; negative regulation of cytokine secretion; negative regulation of toll-like receptor signaling pathway; osteoblast differentiation; positive regulation of canonical Wnt receptor signaling pathway; spermatogenesis; transmembrane signaling receptor activity IPR000276; IPR017452; IPR002131; IPR001611; IPR025875; IPR003591; IPR000372; Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48) Lgr4 Gpr48 Rattus norvegicus (Rat) TR32996_c1_g2_i1 P34268 FLII_CAEEL 9.00E-06 GO:0007275; GO:0005634 multicellular organismal development; nucleus IPR007123; IPR001611; IPR003591; IPR007122; Protein flightless-1 homolog fli-1 B0523.5 Caenorhabditis elegans TR32998_c2_g1_i1 Q8CDU5 EFHB_MOUSE 6.00E-55 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; EF-hand domain-containing family member B Efhb Mus musculus (Mouse) TR32999_c3_g1_i1 Q9D9B4 CJ011_MOUSE 9.00E-20 GO:0030318 melanocyte differentiation IPR001611; IPR003603; Leucine-rich repeat-containing protein C10orf11 homolog Mus musculus (Mouse) TR32999_c3_g1_i2 Q54Q39 PP1R7_DICDI 9.00E-06 GO:0005634 nucleus IPR001611; IPR003603; Protein phosphatase 1 regulatory subunit pprA pprA DDB_G0284039 Dictyostelium discoideum (Slime mold) TR33002_c0_g1_i1 P33010 TERPD_PSESP 1.00E-23 GO:0004022; GO:0008270 alcohol dehydrogenase (NAD) activity; zinc ion binding IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; Probable alcohol dehydrogenase (EC 1.1.1.1) terPD Pseudomonas sp. TR33002_c0_g1_i2 P79896 ADHX_SPAAU 6.00E-155 GO:0051903; GO:0004022; GO:0005737; GO:0006069; GO:0008270 S-(hydroxymethyl)glutathione dehydrogenase activity; alcohol dehydrogenase (NAD) activity; cytoplasm; ethanol oxidation; zinc ion binding IPR014183; IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) Sparus aurata (Gilthead sea bream) TR33006_c0_g2_i1 Q95QN6 YQOE_CAEEL 1.00E-119 GO:0008270 zinc ion binding IPR011422; IPR001841; IPR013083; IPR001607; Uncharacterized RING finger protein EEED8.16 EEED8.16 Caenorhabditis elegans TR33006_c0_g2_i2 Q99MP8 BRAP_MOUSE 0 GO:0000165; GO:0007265; GO:0005737; GO:0009968; GO:0008139; GO:0000166; GO:0000151; GO:0004842; GO:0008270 MAPK cascade; Ras protein signal transduction; cytoplasm; negative regulation of signal transduction; nuclear localization sequence binding; nucleotide binding; ubiquitin ligase complex; ubiquitin-protein ligase activity; zinc ion binding IPR011422; IPR012677; IPR001841; IPR013083; IPR001607; Protein modification; protein ubiquitination. BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) Brap Mus musculus (Mouse) TR33007_c2_g3_i2 Q5RE11 TSN3_PONAB 5.00E-39 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-3 (Tspan-3) TSPAN3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33008_c2_g1_i1 Q9P1Q0 VPS54_HUMAN 3.00E-143 GO:0000938; GO:0040007; GO:0048873; GO:0050881; GO:0060052; GO:0015031; GO:0042147 "GARP complex; growth; homeostasis of number of cells within a tissue; musculoskeletal movement; neurofilament cytoskeleton organization; protein transport; retrograde transport, endosome to Golgi" IPR019515; IPR012501; Vacuolar protein sorting-associated protein 54 (Hepatocellular carcinoma protein 8) (Tumor antigen HOM-HCC-8) (Tumor antigen SLP-8p) VPS54 HCC8 Homo sapiens (Human) TR33009_c5_g1_i3 Q99020 ROAA_MOUSE 2.00E-24 GO:0003677; GO:0003723; GO:0005737; GO:0001837; GO:0000166; GO:0005634; GO:0045893; GO:0030529; GO:0006351 "DNA binding; RNA binding; cytoplasm; epithelial to mesenchymal transition; nucleotide binding; nucleus; positive regulation of transcription, DNA-dependent; ribonucleoprotein complex; transcription, DNA-dependent" IPR012956; IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A) Hnrnpab Cbf-a Cgbfa Hnrpab Mus musculus (Mouse) TR33009_c5_g1_i4 Q99729 ROAA_HUMAN 2.00E-25 GO:0005737; GO:0001837; GO:0003729; GO:0000166; GO:0005634; GO:0045893; GO:0030529 "cytoplasm; epithelial to mesenchymal transition; mRNA binding; nucleotide binding; nucleus; positive regulation of transcription, DNA-dependent; ribonucleoprotein complex" IPR012956; IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (APOBEC1-binding protein 1) (ABBP-1) HNRNPAB ABBP1 HNRPAB Homo sapiens (Human) TR33009_c5_g1_i5 Q99020 ROAA_MOUSE 9.00E-27 GO:0003677; GO:0003723; GO:0005737; GO:0001837; GO:0000166; GO:0005634; GO:0045893; GO:0030529; GO:0006351 "DNA binding; RNA binding; cytoplasm; epithelial to mesenchymal transition; nucleotide binding; nucleus; positive regulation of transcription, DNA-dependent; ribonucleoprotein complex; transcription, DNA-dependent" IPR012956; IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A) Hnrnpab Cbf-a Cgbfa Hnrpab Mus musculus (Mouse) TR33009_c5_g1_i6 Q99729 ROAA_HUMAN 1.00E-25 GO:0005737; GO:0001837; GO:0003729; GO:0000166; GO:0005634; GO:0045893; GO:0030529 "cytoplasm; epithelial to mesenchymal transition; mRNA binding; nucleotide binding; nucleus; positive regulation of transcription, DNA-dependent; ribonucleoprotein complex" IPR012956; IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (APOBEC1-binding protein 1) (ABBP-1) HNRNPAB ABBP1 HNRPAB Homo sapiens (Human) TR33013_c0_g1_i1 Q8R5F7 IFIH1_MOUSE 6.00E-12 GO:0005524; GO:0003677; GO:0005737; GO:0051607; GO:0003725; GO:0004386; GO:0045087; GO:0005634; GO:0032727; GO:0032728; GO:0016925; GO:0042981; GO:0009615; GO:0043021; GO:0003727; GO:0008270 ATP binding; DNA binding; cytoplasm; defense response to virus; double-stranded RNA binding; helicase activity; innate immune response; nucleus; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; protein sumoylation; regulation of apoptotic process; response to virus; ribonucleoprotein complex binding; single-stranded RNA binding; zinc ion binding IPR001315; IPR011029; IPR006935; IPR014001; IPR001650; IPR027417; IPR021673; Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Helicase with 2 CARD domains) (Helicard) (Interferon induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (RIG-I-like receptor 2) (RLR-2) Ifih1 Mus musculus (Mouse) TR33014_c3_g1_i1 Q05695 L1CAM_RAT 4.00E-06 GO:0007155; GO:0030154; GO:0071361; GO:0071560; GO:0005768; GO:0016021; GO:0045121; GO:0007399; GO:0005886 cell adhesion; cell differentiation; cellular response to ethanol; cellular response to transforming growth factor beta stimulus; endosome; integral to membrane; membrane raft; nervous system development; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR026966; Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (Nerve-growth factor-inducible large external glycoprotein) (NILE) (CD antigen CD171) L1cam Caml1 Rattus norvegicus (Rat) TR33015_c0_g1_i1 Q4R367 UFL1_MACFA 0 GO:0071568; GO:0005783; GO:0032088; GO:0031397; GO:0071569 UFM1 conjugating enzyme activity; endoplasmic reticulum; negative regulation of NF-kappaB transcription factor activity; negative regulation of protein ubiquitination; protein ufmylation IPR018611; E3 UFM1-protein ligase 1 (EC 6.3.2.-) UFL1 QtsA-19276 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR33016_c1_g1_i1 Q9NBX4 RTXE_DROME 9.00E-07 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR33018_c0_g1_i2 Q8QGW7 LITAF_CHICK 1.00E-20 GO:0005125; GO:0005737; GO:0006355; GO:0006351 "cytokine activity; cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) TR33018_c0_g1_i4 Q6GZQ0 075L_FRG3G 5.00E-10 GO:0033644; GO:0016021 host cell membrane; integral to membrane IPR006629; Uncharacterized protein 075L FV3-075L Frog virus 3 (isolate Goorha) (FV-3) TR33019_c4_g1_i1 O54928 SOCS5_MOUSE 2.00E-79 GO:0007259; GO:0016049; GO:0019221; GO:0005737; GO:0007173; GO:0019210; GO:0045629; GO:0007175; GO:0045627; GO:0032436; GO:0016567; GO:0040008 JAK-STAT cascade; cell growth; cytokine-mediated signaling pathway; cytoplasm; epidermal growth factor receptor signaling pathway; kinase inhibitor activity; negative regulation of T-helper 2 cell differentiation; negative regulation of epidermal growth factor-activated receptor activity; positive regulation of T-helper 1 cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; regulation of growth IPR000980; IPR022252; IPR001496; Protein modification; protein ubiquitination. Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2-containing protein 5) Socs5 Cish5 Mus musculus (Mouse) TR33019_c5_g1_i1 O04940 CDS1_SOLTU 2.00E-06 GO:0016024; GO:0016021; GO:0004605 CDP-diacylglycerol biosynthetic process; integral to membrane; phosphatidate cytidylyltransferase activity IPR000374; IPR016720; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3. Phosphatidate cytidylyltransferase (EC 2.7.7.41) (CDP-DAG synthase) (CDP-DG synthase) (CDP-diacylglycerol synthase) (CDS) (CDP-diglyceride pyrophosphorylase) (CDP-diglyceride synthase) (CTP:phosphatidate cytidylyltransferase) CDS1 Solanum tuberosum (Potato) TR33019_c5_g2_i4 P56079 CDSA_DROME 9.00E-46 GO:0016024; GO:0016021; GO:0004605; GO:0005886; GO:0010883; GO:0016056; GO:0007430; GO:0043052; GO:0060439; GO:0007601 Q9VXZ3; Q9VXV6 "CDP-diacylglycerol biosynthetic process; integral to membrane; phosphatidate cytidylyltransferase activity; plasma membrane; regulation of lipid storage; rhodopsin mediated signaling pathway; terminal branching, open tracheal system; thermotaxis; trachea morphogenesis; visual perception" IPR000374; IPR016720; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3. "Phosphatidate cytidylyltransferase, photoreceptor-specific (EC 2.7.7.41) (CDP-DAG synthase) (CDP-DG synthase) (CDP-diacylglycerol synthase) (CDS) (CDP-diglyceride pyrophosphorylase) (CDP-diglyceride synthase) (CTP:phosphatidate cytidylyltransferase)" CdsA CG7962 Drosophila melanogaster (Fruit fly) TR33019_c5_g2_i9 Q24K16 ZADH2_BOVIN 6.00E-67 GO:0005739; GO:0016491; GO:0005777; GO:0008270 mitochondrion; oxidoreductase activity; peroxisome; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; IPR002364; Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-) ZADH2 Bos taurus (Bovine) TR33019_c5_g5_i1 Q9C0Y6 YKM8_SCHPO 2.00E-11 GO:0005829; GO:0005634; GO:0016491; GO:0008270 cytosol; nucleus; oxidoreductase activity; zinc ion binding IPR013149; IPR002085; IPR011032; IPR016040; Zinc-type alcohol dehydrogenase-like protein PB24D3.08c (EC 1.-.-.-) SPAPB24D3.08c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR33019_c5_g5_i2 Q24K16 ZADH2_BOVIN 1.00E-29 GO:0005739; GO:0016491; GO:0005777; GO:0008270 mitochondrion; oxidoreductase activity; peroxisome; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; IPR002364; Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-) ZADH2 Bos taurus (Bovine) TR33019_c6_g1_i1 P56079 CDSA_DROME 8.00E-40 GO:0016024; GO:0016021; GO:0004605; GO:0005886; GO:0010883; GO:0016056; GO:0007430; GO:0043052; GO:0060439; GO:0007601 Q9VXZ3; Q9VXV6 "CDP-diacylglycerol biosynthetic process; integral to membrane; phosphatidate cytidylyltransferase activity; plasma membrane; regulation of lipid storage; rhodopsin mediated signaling pathway; terminal branching, open tracheal system; thermotaxis; trachea morphogenesis; visual perception" IPR000374; IPR016720; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3. "Phosphatidate cytidylyltransferase, photoreceptor-specific (EC 2.7.7.41) (CDP-DAG synthase) (CDP-DG synthase) (CDP-diacylglycerol synthase) (CDS) (CDP-diglyceride pyrophosphorylase) (CDP-diglyceride synthase) (CTP:phosphatidate cytidylyltransferase)" CdsA CG7962 Drosophila melanogaster (Fruit fly) TR33020_c1_g1_i1 Q9WVB4 SLIT3_MOUSE 4.00E-10 GO:0035385; GO:0061364; GO:0048846; GO:0007411; GO:0005509; GO:0032870; GO:0005615; GO:0050919; GO:0030308; GO:0008285; GO:0070100; GO:0010629; GO:0009887; GO:0005102; GO:0051414 Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; axon guidance; calcium ion binding; cellular response to hormone stimulus; extracellular space; negative chemotaxis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of chemokine-mediated signaling pathway; negative regulation of gene expression; organ morphogenesis; receptor binding; response to cortisol stimulus IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 3 protein (Slit-3) (Slit3) Slit3 Mus musculus (Mouse) TR33020_c1_g1_i2 O75093 SLIT1_HUMAN 3.00E-13 GO:0048846; GO:0005509; GO:0005737; GO:0033563; GO:0040023; GO:0005615; GO:0048853; GO:0008045; GO:0050919; GO:0048843; GO:0051964; GO:0031290; GO:0021510; GO:0022028 axon extension involved in axon guidance; calcium ion binding; cytoplasm; dorsal/ventral axon guidance; establishment of nucleus localization; extracellular space; forebrain morphogenesis; motor neuron axon guidance; negative chemotaxis; negative regulation of axon extension involved in axon guidance; negative regulation of synapse assembly; retinal ganglion cell axon guidance; spinal cord development; tangential migration from the subventricular zone to the olfactory bulb IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR009030; IPR001791; IPR001611; IPR025875; IPR003591; IPR000372; Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4) SLIT1 KIAA0813 MEGF4 SLIL1 Homo sapiens (Human) TR33022_c1_g2_i1 Q9JI70 MKKS_MOUSE 5.00E-44 GO:0005524; GO:0014824; GO:0048854; GO:0051216; GO:0044267; GO:0005813; GO:0021987; GO:0051131; GO:0005829; GO:0050910; GO:0045444; GO:0021766; GO:0031514; GO:0038108; GO:0045776; GO:0010629; GO:0035058; GO:0045494; GO:0040018; GO:0060296; GO:0007608; GO:0035176; GO:0007286; GO:0021756; GO:0042311 ATP binding; artery smooth muscle contraction; brain morphogenesis; cartilage development; cellular protein metabolic process; centrosome; cerebral cortex development; chaperone-mediated protein complex assembly; cytosol; detection of mechanical stimulus involved in sensory perception of sound; fat cell differentiation; hippocampus development; motile cilium; negative regulation of appetite by leptin-mediated signaling pathway; negative regulation of blood pressure; negative regulation of gene expression; nonmotile primary cilium assembly; photoreceptor cell maintenance; positive regulation of multicellular organism growth; regulation of cilium beat frequency involved in ciliary motility; sensory perception of smell; social behavior; spermatid development; striatum development; vasodilation IPR002423; IPR027409; IPR027413; McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin (Protein Bbs6 homolog) Mkks Bbs6 Mus musculus (Mouse) TR33023_c0_g1_i1 Q6AYF6 GL8D1_RAT 7.00E-85 GO:0016021; GO:0016757 "integral to membrane; transferase activity, transferring glycosyl groups" IPR002495; Glycosyltransferase 8 domain-containing protein 1 (EC 2.4.1.-) Glt8d1 Rattus norvegicus (Rat) TR33023_c0_g1_i2 Q68CQ7 GL8D1_HUMAN 1.00E-83 GO:0016021; GO:0005739; GO:0016757 "integral to membrane; mitochondrion; transferase activity, transferring glycosyl groups" IPR002495; Glycosyltransferase 8 domain-containing protein 1 (EC 2.4.1.-) GLT8D1 GALA4A AD-017 MSTP137 UNQ572/PRO1134 Homo sapiens (Human) TR33024_c0_g1_i2 A5D7S3 TRM1L_BOVIN 2.00E-51 GO:0007610; GO:0046872; GO:0004809; GO:0000049 behavior; metal ion binding; tRNA (guanine-N2-)-methyltransferase activity; tRNA binding IPR002905; IPR007087; IPR015880; TRMT1-like protein (EC 2.1.1.-) TRMT1L Bos taurus (Bovine) TR33026_c0_g2_i1 A0JNN3 MED31_BOVIN 4.00E-60 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR008831; Mediator of RNA polymerase II transcription subunit 31 (Mediator complex subunit 31) (Mediator complex subunit SOH1) MED31 SOH1 Bos taurus (Bovine) TR33031_c1_g1_i2 P50227 ST1A1_BOVIN 7.00E-37 GO:0004062; GO:0006584; GO:0005737; GO:0008202 aryl sulfotransferase activity; catecholamine metabolic process; cytoplasm; steroid metabolic process IPR027417; IPR000863; Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase) (Phenol sulfotransferase) (Phenol-sulfating phenol sulfotransferase) (P-PST) SULT1A1 STP Bos taurus (Bovine) TR33031_c1_g1_i3 O00338 ST1C2_HUMAN 6.00E-36 GO:0050427; GO:0009308; GO:0005829; GO:0015630; GO:0051923; GO:0008146; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; amine metabolic process; cytosol; microtubule cytoskeleton; sulfation; sulfotransferase activity; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase 1C2 (ST1C2) (EC 2.8.2.-) (Sulfotransferase 1C1) (SULT1C#1) (humSULTC2) SULT1C2 SULT1C1 Homo sapiens (Human) TR33033_c1_g2_i1 Q920Q4 VPS16_MOUSE 0 GO:0003779; GO:0005884; GO:0005769; GO:0006886; GO:0031902; GO:0005765 Q9H9C1 actin binding; actin filament; early endosome; intracellular protein transport; late endosome membrane; lysosomal membrane IPR016534; IPR006925; IPR006926; Vacuolar protein sorting-associated protein 16 homolog (mVPS16) Vps16 Mus musculus (Mouse) TR33033_c1_g2_i2 Q920Q4 VPS16_MOUSE 0 GO:0003779; GO:0005884; GO:0005769; GO:0006886; GO:0031902; GO:0005765 Q9H9C1 actin binding; actin filament; early endosome; intracellular protein transport; late endosome membrane; lysosomal membrane IPR016534; IPR006925; IPR006926; Vacuolar protein sorting-associated protein 16 homolog (mVPS16) Vps16 Mus musculus (Mouse) TR33035_c0_g2_i1 Q653P0 KOR1_ORYSJ 5.00E-09 GO:0016021; GO:0005249 integral to membrane; voltage-gated potassium channel activity IPR002110; IPR020683; IPR018490; IPR000595; IPR005821; IPR021789; IPR003938; IPR014710; Potassium channel KOR1 (K(+) outward-rectifying channel 1) Os06g0250600 LOC_Os06g14030 OSJNBa0091G06.35 P0431E05.11 Oryza sativa subsp. japonica (Rice) TR33035_c0_g2_i2 P16157 ANK1_HUMAN 8.00E-25 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR33036_c0_g1_i2 Q9TWL9 COMA_CONMA 5.00E-09 GO:0005576; GO:0016042; GO:0004623 extracellular region; lipid catabolic process; phospholipase A2 activity IPR016090; Conodipine-M alpha chain (PLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) Conus magus (Magus cone) (Magician's cone snail) TR33037_c1_g1_i1 Q9H4G4 GAPR1_HUMAN 2.00E-23 GO:0000139; GO:0005576 Golgi membrane; extracellular region IPR001283; IPR018244; IPR014044; Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) GLIPR2 C9orf19 GAPR1 Homo sapiens (Human) TR33040_c2_g1_i2 Q1RMP0 RPA12_BOVIN 1.00E-34 GO:0003899; GO:0003676; GO:0005730; GO:0006351; GO:0008270 "DNA-directed RNA polymerase activity; nucleic acid binding; nucleolus; transcription, DNA-dependent; zinc ion binding" IPR019761; IPR012164; IPR001222; DNA-directed RNA polymerase I subunit RPA12 (Zinc ribbon domain-containing protein 1) ZNRD1 Bos taurus (Bovine) TR33040_c3_g1_i1 P84875 PCPI_SABMA 3.00E-30 GO:0008191; GO:0004867 metalloendopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Carboxypeptidase inhibitor SmCI Sabellastarte magnifica (Feather duster) TR33043_c0_g1_i1 P22194 SDS22_SCHPO 1.00E-11 GO:0051301; GO:0005829; GO:0051457; GO:0007067; GO:0005634; GO:1901970; GO:0071862; GO:0000164; GO:0030071; GO:0009966 cell division; cytosol; maintenance of protein location in nucleus; mitosis; nucleus; positive regulation of mitotic sister chromatid separation; protein phosphatase type 1 activator activity; protein phosphatase type 1 complex; regulation of mitotic metaphase/anaphase transition; regulation of signal transduction IPR001611; IPR025875; IPR003603; Protein phosphatase 1 regulatory subunit SDS22 sds22 SPAC4A8.12c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR33043_c1_g1_i1 Q9D5E4 LRC48_MOUSE 8.00E-111 GO:0005737 cytoplasm IPR001611; Leucine-rich repeat-containing protein 48 Lrrc48 Mus musculus (Mouse) TR33045_c0_g2_i1 O17581 SCC4_CAEEL 4.00E-13 GO:0032116; GO:0033564; GO:0030424; GO:0051301; GO:0000785; GO:0005737; GO:0033563; GO:0034088; GO:0005654; GO:0018991 SMC loading complex; anterior/posterior axon guidance; axon; cell division; chromatin; cytoplasm; dorsal/ventral axon guidance; maintenance of mitotic sister chromatid cohesion; nucleoplasm; oviposition IPR019440; IPR011990; Maternal uncoordinated protein 2 (Cohesin loading complex subunit SCC4 homolog) mau-2 C09H6.3 Caenorhabditis elegans TR33045_c1_g1_i1 B1H1Z8 SCC4_XENTR 6.00E-111 GO:0032116; GO:0051301; GO:0000785; GO:0034088; GO:0005654 SMC loading complex; cell division; chromatin; maintenance of mitotic sister chromatid cohesion; nucleoplasm IPR019440; IPR011990; MAU2 chromatid cohesion factor homolog (MAU-2) (Cohesin loading complex subunit SCC4 homolog) mau2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33046_c4_g4_i1 Q80ZA5 S4A10_RAT 0 GO:0016323; GO:0005452; GO:0016021; GO:0006885; GO:0006814; GO:0015293 P70441 basolateral plasma membrane; inorganic anion exchanger activity; integral to membrane; regulation of pH; sodium ion transport; symporter activity IPR013769; IPR011531; IPR003020; IPR003024; IPR016152; Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10) Slc4a10 Ncbe Rattus norvegicus (Rat) TR33046_c4_g4_i2 Q80ZA5 S4A10_RAT 0 GO:0016323; GO:0005452; GO:0016021; GO:0006885; GO:0006814; GO:0015293 P70441 basolateral plasma membrane; inorganic anion exchanger activity; integral to membrane; regulation of pH; sodium ion transport; symporter activity IPR013769; IPR011531; IPR003020; IPR003024; IPR016152; Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10) Slc4a10 Ncbe Rattus norvegicus (Rat) TR33047_c0_g1_i1 Q3T0Y3 ST1B1_BOVIN 2.00E-45 GO:0004062; GO:0005737; GO:0009812; GO:0008202; GO:0051923; GO:0042403; GO:0006805 aryl sulfotransferase activity; cytoplasm; flavonoid metabolic process; steroid metabolic process; sulfation; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) SULT1B1 Bos taurus (Bovine) TR33049_c2_g1_i1 P26927 HGFL_HUMAN 1.00E-30 GO:0005576; GO:0006508; GO:0004252 extracellular region; proteolysis; serine-type endopeptidase activity IPR024174; IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR001254; IPR001314; IPR009003; Hepatocyte growth factor-like protein (Macrophage stimulatory protein) (Macrophage-stimulating protein) (MSP) [Cleaved into: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain] MST1 D3F15S2 DNF15S2 HGFL Homo sapiens (Human) TR33049_c2_g1_i2 P06867 PLMN_PIG 1.00E-78 GO:0007596; GO:0005576; GO:0042730; GO:0006508; GO:0004252; GO:0048771 blood coagulation; extracellular region; fibrinolysis; proteolysis; serine-type endopeptidase activity; tissue remodeling IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Sus scrofa (Pig) TR33050_c7_g1_i1 Q66IC8 TC1D1_DANRE 7.00E-28 IPR005334; Tctex1 domain-containing protein 1 tctex1d1 zgc:101774 Danio rerio (Zebrafish) (Brachydanio rerio) TR33050_c7_g1_i2 A2VDD2 TC1DB_XENLA 6.00E-29 IPR005334; Tctex1 domain-containing protein 1-B (Fragment) tctex1d1-b Xenopus laevis (African clawed frog) TR33050_c7_g1_i3 Q8CDY7 TC1D4_MOUSE 3.00E-21 IPR005334; Tctex1 domain-containing protein 4 Tctex1d4 Mus musculus (Mouse) TR33052_c0_g1_i1 Q5E9T4 TPK1_BOVIN 5.00E-73 GO:0005524; GO:0016301; GO:0009229; GO:0004788; GO:0006772 ATP binding; kinase activity; thiamine diphosphate biosynthetic process; thiamine diphosphokinase activity; thiamine metabolic process IPR006282; IPR016966; IPR007373; IPR007371; Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1. Thiamin pyrophosphokinase 1 (EC 2.7.6.2) (Thiamine pyrophosphokinase 1) TPK1 Bos taurus (Bovine) TR33054_c0_g1_i1 Q5E9G6 FBX8_BOVIN 2.00E-57 GO:0005086; GO:0030036; GO:0030054; GO:0005634; GO:0032012; GO:0000151; GO:0006511 ARF guanyl-nucleotide exchange factor activity; actin cytoskeleton organization; cell junction; nucleus; regulation of ARF protein signal transduction; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process IPR001810; IPR023394; IPR000904; F-box only protein 8 FBXO8 Bos taurus (Bovine) TR33054_c0_g2_i2 Q9P7V5 SEC7B_SCHPO 3.00E-13 GO:0005086; GO:0006888; GO:0000137; GO:0000138; GO:0005798; GO:0005938; GO:0006886; GO:0005635; GO:0032012 ARF guanyl-nucleotide exchange factor activity; ER to Golgi vesicle-mediated transport; Golgi cis cisterna; Golgi trans cisterna; Golgi-associated vesicle; cell cortex; intracellular protein transport; nuclear envelope; regulation of ARF protein signal transduction IPR016024; IPR015403; IPR023394; IPR000904; Protein transport protein sec72 sec72 sec7b SPAC30.01c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR33055_c0_g2_i1 Q9VKJ9 C2D1_DROME 2.00E-111 GO:0007219; GO:0016324; GO:0048749; GO:0005737; GO:0016197; GO:0008586; GO:0006886; GO:0045746; GO:0005543; GO:0030100; GO:0045035 Notch signaling pathway; apical plasma membrane; compound eye development; cytoplasm; endosomal transport; imaginal disc-derived wing vein morphogenesis; intracellular protein transport; negative regulation of Notch signaling pathway; phospholipid binding; regulation of endocytosis; sensory organ precursor cell division IPR000008; IPR006608; Coiled-coil and C2 domain-containing protein 1-like (Lethal giant disks protein) l(2)gd1 lgd CG4713 Drosophila melanogaster (Fruit fly) TR33055_c0_g2_i2 Q66HA5 C2D1A_RAT 2.00E-102 GO:0003677; GO:0005737; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cytoplasm; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000008; IPR006608; Coiled-coil and C2 domain-containing protein 1A (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) Cc2d1a Rattus norvegicus (Rat) TR33058_c0_g2_i1 Q6NUP7 PP4R4_HUMAN 6.00E-87 GO:0005737; GO:0032515; GO:0019888; GO:0008287; GO:0080163 P60510 cytoplasm; negative regulation of phosphoprotein phosphatase activity; protein phosphatase regulator activity; protein serine/threonine phosphatase complex; regulation of protein serine/threonine phosphatase activity IPR011989; IPR016024; IPR021133; Serine/threonine-protein phosphatase 4 regulatory subunit 4 PPP4R4 KIAA1622 PP4R4 Homo sapiens (Human) TR33058_c0_g2_i2 Q6NUP7 PP4R4_HUMAN 2.00E-102 GO:0005737; GO:0032515; GO:0019888; GO:0008287; GO:0080163 P60510 cytoplasm; negative regulation of phosphoprotein phosphatase activity; protein phosphatase regulator activity; protein serine/threonine phosphatase complex; regulation of protein serine/threonine phosphatase activity IPR011989; IPR016024; IPR021133; Serine/threonine-protein phosphatase 4 regulatory subunit 4 PPP4R4 KIAA1622 PP4R4 Homo sapiens (Human) TR33059_c0_g1_i1 Q0V9M0 CRAC1_XENTR 3.00E-162 GO:0005509; GO:0005578 calcium ion binding; proteinaceous extracellular matrix IPR027039; IPR001881; IPR018097; IPR011519; Cartilage acidic protein 1 (ASPIC) crtac1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33060_c1_g3_i2 Q9JM98 WRP73_MOUSE 7.00E-105 GO:0005813; GO:0005737 centrosome; cytoplasm IPR011044; IPR015943; IPR001680; WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene) Wrap73 Dd57 Wdr8 Mus musculus (Mouse) TR33061_c0_g1_i1 Q8R0C0 RPC7L_MOUSE 4.00E-16 IPR024661; DNA-directed RNA polymerase III subunit RPC7-like (RNA polymerase III subunit C7-like) (DNA-directed RNA polymerase III subunit G-like) Polr3gl Mus musculus (Mouse) TR33063_c0_g1_i2 Q9VUC6 Y2138_DROME 1.00E-78 GO:0003779; GO:0030036; GO:0048812 actin binding; actin cytoskeleton organization; neuron projection morphogenesis IPR016024; IPR014767; IPR015425; IPR010472; IPR010473; IPR014768; Formin-like protein CG32138 CG32138 Drosophila melanogaster (Fruit fly) TR33063_c0_g1_i3 A2APV2 FMNL2_MOUSE 3.00E-148 GO:0030866; GO:0005737; GO:0022604 cortical actin cytoskeleton organization; cytoplasm; regulation of cell morphogenesis IPR016024; IPR015425; IPR010472; IPR027656; IPR010473; IPR014768; Formin-like protein 2 (Protein Man) Fmnl2 Kiaa1902 Man Mus musculus (Mouse) TR33065_c0_g1_i1 P81693 PPAC_PIG 3.00E-50 GO:0003993; GO:0005737; GO:0004726; GO:0035335 acid phosphatase activity; cytoplasm; non-membrane spanning protein tyrosine phosphatase activity; peptidyl-tyrosine dephosphorylation IPR023485; IPR002115; IPR000106; IPR017867; Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) ACP1 Sus scrofa (Pig) TR33065_c0_g1_i3 P82890 PPAC1_DROME 4.00E-38 GO:0003993; GO:0005737; GO:0004726; GO:0004725 acid phosphatase activity; cytoplasm; non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine phosphatase activity IPR023485; IPR002115; IPR000106; IPR017867; Low molecular weight phosphotyrosine protein phosphatase 1 (EC 3.1.3.48) (Low molecular weight cytosolic acid phosphatase 1) (EC 3.1.3.2) (PTPase 1) primo-1 CG31311 Drosophila melanogaster (Fruit fly) TR33066_c1_g1_i1 Q5KD76 MTND_CRYNJ 1.00E-42 GO:0019509; GO:0010309; GO:0005737; GO:0005506; GO:0005634 L-methionine salvage from methylthioadenosine; acireductone dioxygenase [iron(II)-requiring] activity; cytoplasm; iron ion binding; nucleus IPR004313; IPR027496; IPR014710; IPR011051; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6. "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54) (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD) (Fe-ARD)" ADI1 CNH03570 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR33066_c1_g1_i4 C3ZAH2 MTND_BRAFL 4.00E-76 GO:0019509; GO:0010309; GO:0005737; GO:0005506; GO:0005634 L-methionine salvage from methylthioadenosine; acireductone dioxygenase [iron(II)-requiring] activity; cytoplasm; iron ion binding; nucleus IPR004313; IPR027496; IPR014710; IPR011051; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6. "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54) (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD) (Fe-ARD)" BRAFLDRAFT_119977 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR33072_c0_g1_i1 Q9BU79 CG023_HUMAN 6.00E-33 GO:0016021 integral to membrane IPR022564; Transmembrane protein 243 TMEM243 C7orf23 Homo sapiens (Human) TR33073_c5_g4_i2 Q5UNS9 COLL7_MIMIV 3.00E-16 GO:0005581; GO:0019012 collagen; virion IPR008160; Collagen-like protein 7 MIMI_L669 Acanthamoeba polyphaga mimivirus (APMV) TR33074_c0_g2_i1 Q9W303 IDGF4_DROME 2.00E-17 GO:0005975; GO:0006032; GO:0004568; GO:0005576; GO:0007444; GO:0008084 carbohydrate metabolic process; chitin catabolic process; chitinase activity; extracellular region; imaginal disc development; imaginal disc growth factor receptor binding IPR011583; IPR001223; IPR013781; IPR017853; IPR015520; Chitinase-like protein Idgf4 (Imaginal disk growth factor protein 4) Idgf4 CG1780 Drosophila melanogaster (Fruit fly) TR33074_c0_g3_i1 Q13231 CHIT1_HUMAN 3.00E-87 GO:0008061; GO:0006032; GO:0008843; GO:0005615; GO:0006955; GO:0005764; GO:0000272; GO:0009617 chitin binding; chitin catabolic process; endochitinase activity; extracellular space; immune response; lysosome; polysaccharide catabolic process; response to bacterium IPR002557; IPR011583; IPR001223; IPR001579; IPR013781; IPR017853; Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) CHIT1 Homo sapiens (Human) TR33075_c0_g1_i1 G5E8K5 ANK3_MOUSE 4.00E-26 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR33077_c5_g1_i1 Q9D6K9 CERS5_MOUSE 1.00E-56 GO:0046513; GO:0005783; GO:0005789; GO:0016021; GO:0031965; GO:0043565; GO:0003700; GO:0050291 ceramide biosynthetic process; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nuclear membrane; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sphingosine N-acyltransferase activity IPR001356; IPR009057; IPR016439; IPR006634; Lipid metabolism; sphingolipid metabolism. Ceramide synthase 5 (CerS5) (EC 2.3.1.24) (LAG1 longevity assurance homolog 5) (Translocating chain-associating membrane protein homolog 4) (TRAM homolog 4) Cers5 Lass5 Trh4 Mus musculus (Mouse) TR33077_c5_g1_i2 Q3ZBF8 CERS2_BOVIN 1.00E-53 GO:0005789; GO:0016021; GO:0006629; GO:0031965; GO:0043565; GO:0003700 endoplasmic reticulum membrane; integral to membrane; lipid metabolic process; nuclear membrane; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR001356; IPR009057; IPR016439; IPR006634; Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) CERS2 LASS2 Bos taurus (Bovine) TR33078_c4_g1_i1 Q8BHL8 PSMF1_MOUSE 3.00E-45 GO:0000502 proteasome complex IPR021625; IPR013886; Proteasome inhibitor PI31 subunit Psmf1 Mus musculus (Mouse) TR33078_c4_g1_i3 Q9V637 PSMF1_DROME 2.00E-11 GO:0008584; GO:0007140; GO:0032436; GO:0043248; GO:0000502; GO:0006974; GO:0070864 Q9VYG1; Q9VFS8; Q8SX86; P18053; Q9VBP3 male gonad development; male meiosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome assembly; proteasome complex; response to DNA damage stimulus; sperm individualization complex IPR021625; Putative proteasome inhibitor CG8979 Drosophila melanogaster (Fruit fly) TR33079_c1_g1_i2 Q8BML1 MICA2_MOUSE 4.00E-70 GO:0071949; GO:0003779; GO:0030042; GO:0005737; GO:0005856; GO:0016709; GO:0019417; GO:0008270 "FAD binding; actin binding; actin filament depolymerization; cytoplasm; cytoskeleton; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; sulfur oxidation; zinc ion binding" IPR001715; IPR002938; IPR003042; IPR001781; Protein-methionine sulfoxide oxidase MICAL2 (EC 1.14.13.-) (Molecule interacting with CasL protein 2) (MICAL-2) (mMical2) Mical2 Kiaa0750 Mus musculus (Mouse) TR33081_c1_g1_i1 A8XJ44 OXDA2_CAEBR 3.00E-44 GO:0003884; GO:0005777 D-amino-acid oxidase activity; peroxisome IPR023209; IPR006076; IPR016040; D-amino-acid oxidase 2 (DAAO 2) (DAMOX 2) (DAO 2) (EC 1.4.3.3) CBG13882 Caenorhabditis briggsae TR33081_c1_g1_i2 P18894 OXDA_MOUSE 5.00E-65 GO:0055130; GO:0003884; GO:0036088; GO:0071949; GO:0048037; GO:0005829; GO:0042416; GO:0006551; GO:0005741; GO:0005778; GO:0006562 D-alanine catabolic process; D-amino-acid oxidase activity; D-serine catabolic process; FAD binding; cofactor binding; cytosol; dopamine biosynthetic process; leucine metabolic process; mitochondrial outer membrane; peroxisomal membrane; proline catabolic process IPR023209; IPR006181; IPR006076; IPR016040; D-amino-acid oxidase (DAAO) (DAMOX) (DAO) (EC 1.4.3.3) Dao Dao1 Mus musculus (Mouse) TR33082_c0_g1_i1 P11884 ALDH2_RAT 1.00E-137 GO:0070404; GO:0004029; GO:0071398; GO:0032870; GO:0006068; GO:0042802; GO:0001889; GO:0005759; GO:0005739; GO:0043066; GO:0032355; GO:0055093; GO:0032496; GO:0035094; GO:0032570; GO:0033574 NADH binding; aldehyde dehydrogenase (NAD) activity; cellular response to fatty acid; cellular response to hormone stimulus; ethanol catabolic process; identical protein binding; liver development; mitochondrial matrix; mitochondrion; negative regulation of apoptotic process; response to estradiol stimulus; response to hyperoxia; response to lipopolysaccharide; response to nicotine; response to progesterone stimulus; response to testosterone stimulus IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. "Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDH1)" Aldh2 Rattus norvegicus (Rat) TR33082_c0_g2_i2 P22281 ALDHX_YEASX 3.00E-09 GO:0004029; GO:0006068; GO:0005759 aldehyde dehydrogenase (NAD) activity; ethanol catabolic process; mitochondrial matrix IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. "Aldehyde dehydrogenase 1, mitochondrial (EC 1.2.1.3)" ALD1 ALDH ALDH1 Saccharomyces cerevisiae (Baker's yeast) TR33082_c0_g2_i4 Q29491 ALDH2_MACPR 1.00E-33 GO:0004029; GO:0005737; GO:0006068 aldehyde dehydrogenase (NAD) activity; cytoplasm; ethanol catabolic process IPR016161; IPR016163; IPR016160; IPR015590; Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. "Aldehyde dehydrogenase, cytosolic 2 (EC 1.2.1.3) (ALDH class 1) (ALDH1-NL) (Non-lens ALDH1) (Fragment)" Macroscelides proboscideus (Short-eared elephant shrew) TR33082_c0_g3_i1 Q7SY23 AL4A1_DANRE 7.00E-08 GO:0003842; GO:0005759; GO:0016620; GO:0006561; GO:0010133 "1-pyrroline-5-carboxylate dehydrogenase activity; mitochondrial matrix; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; proline biosynthetic process; proline catabolic process to glutamate" IPR005931; IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2. "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase)" aldh4a1 zgc:63592 Danio rerio (Zebrafish) (Brachydanio rerio) TR33083_c2_g2_i1 Q658N2 WSCD1_HUMAN 2.00E-06 GO:0016021; GO:0008146 integral to membrane; sulfotransferase activity IPR027417; IPR000863; IPR002889; IPR013994; WSC domain-containing protein 1 WSCD1 KIAA0523 Homo sapiens (Human) TR33083_c2_g2_i2 A2BGL3 WSCD2_DANRE 2.00E-09 GO:0016021; GO:0008146 integral to membrane; sulfotransferase activity IPR027417; IPR000863; IPR002889; IPR013994; WSC domain-containing protein 2 wscd2 si:ch211-240b21.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR33083_c2_g2_i3 P84675 PFM_CHAGB 1.00E-09 GO:0050832; GO:0031640 defense response to fungus; killing of cells of other organism IPR002889; IPR013994; Putative fungistatic metabolite CHGG_05463 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) TR33083_c2_g5_i1 P84675 PFM_CHAGB 9.00E-09 GO:0050832; GO:0031640 defense response to fungus; killing of cells of other organism IPR002889; IPR013994; Putative fungistatic metabolite CHGG_05463 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) TR33083_c2_g5_i3 Q80XH4 WSCD1_MOUSE 1.00E-07 GO:0016021; GO:0008146 integral to membrane; sulfotransferase activity IPR027417; IPR000863; IPR002889; IPR013994; WSC domain-containing protein 1 Wscd1 Kiaa0523 Mus musculus (Mouse) TR33083_c2_g6_i1 A2BGL3 WSCD2_DANRE 2.00E-09 GO:0016021; GO:0008146 integral to membrane; sulfotransferase activity IPR027417; IPR000863; IPR002889; IPR013994; WSC domain-containing protein 2 wscd2 si:ch211-240b21.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR33083_c2_g6_i2 Q8K1S7 KREM2_MOUSE 4.00E-08 GO:0016055; GO:0016021 Wnt receptor signaling pathway; integral to membrane IPR000859; IPR017076; IPR000001; IPR013806; IPR018056; IPR002889; Kremen protein 2 (Dickkopf receptor 2) (Kringle domain-containing transmembrane protein 2) (Kringle-containing protein marking the eye and the nose) Kremen2 Mus musculus (Mouse) TR33085_c0_g1_i1 Q6ZS10 CL17A_HUMAN 1.00E-12 GO:0009986; GO:0042806; GO:0016021; GO:0005537; GO:0046872 cell surface; fucose binding; integral to membrane; mannose binding; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; "C-type lectin domain family 17, member A (Prolectin)" CLEC17A Homo sapiens (Human) TR33085_c0_g1_i2 P35246 SFTPD_BOVIN 9.00E-09 GO:0030246; GO:0005581; GO:0005615; GO:0048286; GO:0007585; GO:0043129 carbohydrate binding; collagen; extracellular space; lung alveolus development; respiratory gaseous exchange; surfactant homeostasis IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; IPR015097; Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (Lung surfactant protein D) SFTPD SFTP4 Bos taurus (Bovine) TR33087_c2_g1_i1 Q0VC84 C1GLT_BOVIN 5.00E-45 GO:0016266; GO:0001525; GO:0030154; GO:0016263; GO:0016021; GO:0001822; GO:0046872 O-glycan processing; angiogenesis; cell differentiation; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity; integral to membrane; kidney development; metal ion binding IPR026842; IPR003378; Protein modification; protein glycosylation. "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (Core 1 O-glycan T-synthase) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1)" C1GALT1 Bos taurus (Bovine) TR33088_c0_g1_i1 Q5TC84 OGRL1_HUMAN 2.00E-56 GO:0016020; GO:0004872 membrane; receptor activity IPR006757; Opioid growth factor receptor-like protein 1 OGFRL1 Homo sapiens (Human) TR33089_c2_g1_i1 Q7Z429 LFG1_HUMAN 2.00E-50 GO:0016021 integral to membrane IPR006214; Protein lifeguard 1 (Glutamate [NMDA] receptor-associated protein 1) (NMDA receptor glutamate-binding subunit) (Putative MAPK-activating protein PM02) (Transmembrane BAX inhibitor motif-containing protein 3) GRINA LFG1 NMDARA1 TMBIM3 Homo sapiens (Human) TR33089_c2_g1_i2 P48558 BXI1_YEAST 2.00E-08 GO:0006915; GO:0019722; GO:0005783; GO:0005789; GO:0030968; GO:0000324; GO:0016021; GO:0031966; GO:0005739; GO:0005774 apoptotic process; calcium-mediated signaling; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum unfolded protein response; fungal-type vacuole; integral to membrane; mitochondrial membrane; mitochondrion; vacuolar membrane IPR006214; Bax inhibitor 1 (BH3 domain-containing protein BXI1) BXI1 YBH3 YNL305C N0405 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33089_c3_g1_i2 P54637 PTP3_DICDI 1.00E-07 GO:0005737; GO:0007243; GO:0035335; GO:0016791; GO:0034504; GO:0004725; GO:0006970; GO:0042501 cytoplasm; intracellular protein kinase cascade; peptidyl-tyrosine dephosphorylation; phosphatase activity; protein localization to nucleus; protein tyrosine phosphatase activity; response to osmotic stress; serine phosphorylation of STAT protein IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase 3 (EC 3.1.3.48) (Protein-tyrosine-phosphate phosphohydrolase 3) ptpC ptp3 DDB_G0282145 Dictyostelium discoideum (Slime mold) TR33090_c0_g1_i1 Q4WCR3 PPIL1_ASPFU 6.00E-39 GO:0003755; GO:0006457; GO:0000413 peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase-like 1 (PPIase) (EC 5.2.1.8) (Rotamase) cyp1 AFUA_6G02140 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) TR33090_c0_g2_i1 Q29RZ2 PPWD1_BOVIN 0 GO:0008380; GO:0071013; GO:0006397; GO:0003755; GO:0006457; GO:0000413 RNA splicing; catalytic step 2 spliceosome; mRNA processing; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR015943; IPR001680; IPR017986; Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8) PPWD1 Bos taurus (Bovine) TR33091_c4_g2_i1 Q29611 CLN3_CANFA 7.00E-108 GO:0000139; GO:0005795; GO:0042987; GO:0015809; GO:0005901; GO:0005769; GO:0006681; GO:0001575; GO:0006678; GO:0030176; GO:0005770; GO:0007042; GO:0035752; GO:0005765; GO:0043066; GO:0043005; GO:0005634; GO:0006898; GO:0006684; GO:0008021; GO:0005802; GO:0007034; GO:0047496 Golgi membrane; Golgi stack; amyloid precursor protein catabolic process; arginine transport; caveola; early endosome; galactosylceramide metabolic process; globoside metabolic process; glucosylceramide metabolic process; integral to endoplasmic reticulum membrane; late endosome; lysosomal lumen acidification; lysosomal lumen pH elevation; lysosomal membrane; negative regulation of apoptotic process; neuron projection; nucleus; receptor-mediated endocytosis; sphingomyelin metabolic process; synaptic vesicle; trans-Golgi network; vacuolar transport; vesicle transport along microtubule IPR003492; IPR018460; IPR016196; Battenin (Protein CLN3) CLN3 Canis familiaris (Dog) (Canis lupus familiaris) TR33092_c0_g1_i2 Q66KX2 CADM4_XENLA 9.00E-06 GO:0007155; GO:0016021 cell adhesion; integral to membrane IPR013162; IPR007110; IPR013783; IPR003599; IPR003598; IPR013106; IPR003585; Cell adhesion molecule 4 (Immunoglobulin superfamily member 4C) (IgSF4C) cadm4 igsf4c Xenopus laevis (African clawed frog) TR33092_c0_g1_i5 Q8N126 CADM3_HUMAN 2.00E-07 GO:0034332; GO:0034329; GO:0005911; GO:0007157; GO:0007156; GO:0016021; GO:0005886; GO:0042803; GO:0008104 adherens junction organization; cell junction assembly; cell-cell junction; heterophilic cell-cell adhesion; homophilic cell adhesion; integral to membrane; plasma membrane; protein homodimerization activity; protein localization IPR013162; IPR007110; IPR013783; IPR003599; IPR003598; IPR013106; IPR003585; Cell adhesion molecule 3 (Brain immunoglobulin receptor) (Immunoglobulin superfamily member 4B) (IgSF4B) (Nectin-like protein 1) (NECL-1) (Synaptic cell adhesion molecule 3) (SynCAM3) (TSLC1-like protein 1) (TSLL1) CADM3 IGSF4B NECL1 SYNCAM3 TSLL1 UNQ225/PRO258 Homo sapiens (Human) TR33094_c4_g1_i1 Q7T2Q4 PA2A2_BUNFL 1.00E-13 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Acidic phospholipase A2 2 (svPLA2) (EC 3.1.1.4) (PA2-II) (Phosphatidylcholine 2-acylhydrolase) Bungarus flaviceps flaviceps (Red-headed krait) TR33094_c4_g1_i2 P31854 PA2B_VIPBB 8.00E-13 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Basic phospholipase A2 Pla2Vb (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) Vipera berus berus (Common viper) TR33094_c4_g1_i3 Q8QFW4 PA2B1_BUNCE 2.00E-12 GO:0005509; GO:0016042; GO:0072556; GO:0004623; GO:0006644 calcium ion binding; lipid catabolic process; other organism presynaptic membrane; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Basic phospholipase A2 beta-bungarotoxin A1 chain (Beta-BuTX A1 chain) (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) Bungarus caeruleus (Indian krait) TR33094_c5_g1_i2 Q55E58 PATS1_DICDI 2.00E-14 GO:0005524; GO:0005525; GO:0042641; GO:0000281; GO:0004721; GO:0006470; GO:0004674; GO:0007264 ATP binding; GTP binding; actomyosin; mitotic cytokinesis; phosphoprotein phosphatase activity; protein dephosphorylation; protein serine/threonine kinase activity; small GTPase mediated signal transduction IPR011009; IPR001611; IPR013684; IPR010569; IPR017906; IPR027417; IPR000719; IPR011047; IPR020859; IPR001245; IPR008271; IPR005225; IPR001806; IPR015943; IPR001680; IPR017986; Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) TR33098_c10_g1_i4 Q571F8 GLSL_MOUSE 2.00E-12 GO:0004359; GO:0006541; GO:0005739; GO:0072593; GO:0042981 glutaminase activity; glutamine metabolic process; mitochondrion; reactive oxygen species metabolic process; regulation of apoptotic process IPR002110; IPR020683; IPR012338; IPR015868; "Glutaminase liver isoform, mitochondrial (GLS) (EC 3.5.1.2) (L-glutaminase) (L-glutamine amidohydrolase)" Gls2 Kiaa4146 Mus musculus (Mouse) TR33098_c3_g1_i1 P28492 GLSL_RAT 1.00E-09 GO:0004359; GO:0006541; GO:0005759; GO:0072593; GO:0042981 glutaminase activity; glutamine metabolic process; mitochondrial matrix; reactive oxygen species metabolic process; regulation of apoptotic process IPR002110; IPR020683; IPR012338; IPR015868; "Glutaminase liver isoform, mitochondrial (GLS) (EC 3.5.1.2) (L-glutaminase) (L-glutamine amidohydrolase)" Gls2 Ga Rattus norvegicus (Rat) TR33104_c2_g3_i1 Q58DS3 S2535_BOVIN 4.00E-16 GO:0016021; GO:0005743; GO:0006810 integral to membrane; mitochondrial inner membrane; transport IPR018108; IPR023395; Solute carrier family 25 member 35 SLC25A35 Bos taurus (Bovine) TR33104_c2_g3_i2 Q5SVS4 KMCP1_HUMAN 3.00E-130 GO:0016021; GO:0005743; GO:0006839; GO:0005739 integral to membrane; mitochondrial inner membrane; mitochondrial transport; mitochondrion IPR002030; IPR018108; IPR023395; Kidney mitochondrial carrier protein 1 (Solute carrier family 25 member 30) SLC25A30 KMCP1 Homo sapiens (Human) TR33104_c2_g3_i3 Q54B67 MCFZ_DICDI 7.00E-13 GO:0016021; GO:0005743; GO:0005469 integral to membrane; mitochondrial inner membrane; succinate:fumarate antiporter activity IPR018108; IPR023395; Mitochondrial substrate carrier family protein Z mcfZ mitA DDB_G0293874 Dictyostelium discoideum (Slime mold) TR33104_c2_g3_i6 Q5SVS4 KMCP1_HUMAN 5.00E-130 GO:0016021; GO:0005743; GO:0006839; GO:0005739 integral to membrane; mitochondrial inner membrane; mitochondrial transport; mitochondrion IPR002030; IPR018108; IPR023395; Kidney mitochondrial carrier protein 1 (Solute carrier family 25 member 30) SLC25A30 KMCP1 Homo sapiens (Human) TR33106_c0_g1_i1 A1BHL1 DNAJ_CHLPD 2.00E-06 GO:0005524; GO:0006260; GO:0005737; GO:0006457; GO:0009408; GO:0008270 ATP binding; DNA replication; cytoplasm; protein folding; response to heat; zinc ion binding IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; Chaperone protein DnaJ dnaJ Cpha266_1872 Chlorobium phaeobacteroides (strain DSM 266) TR33106_c0_g1_i2 Q6NWJ4 DNJC2_DANRE 5.00E-123 GO:0003677; GO:0003682; GO:0016568; GO:0005829; GO:0042393; GO:0005634; GO:0045893; GO:0006351; GO:0043130 "DNA binding; chromatin binding; chromatin modification; cytosol; histone binding; nucleus; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin binding" IPR001623; IPR009057; IPR001005; IPR017884; DnaJ homolog subfamily C member 2 dnajc2 zgc:85671 Danio rerio (Zebrafish) (Brachydanio rerio) TR33109_c0_g1_i1 Q0P5H7 SYRM_BOVIN 1.00E-59 GO:0005524; GO:0004814; GO:0006420; GO:0005759 ATP binding; arginine-tRNA ligase activity; arginyl-tRNA aminoacylation; mitochondrial matrix IPR001412; IPR001278; IPR015945; IPR005148; IPR008909; IPR014729; IPR009080; "Probable arginine--tRNA ligase, mitochondrial (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)" RARS2 RARSL Bos taurus (Bovine) TR33109_c0_g1_i2 A9A099 SYR_DESOH 5.00E-07 GO:0005524; GO:0004814; GO:0006420; GO:0005737 ATP binding; arginine-tRNA ligase activity; arginyl-tRNA aminoacylation; cytoplasm IPR001412; IPR001278; IPR015945; IPR005148; IPR008909; IPR014729; IPR009080; Arginine--tRNA ligase (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS) argS Dole_3215 Desulfococcus oleovorans (strain DSM 6200 / Hxd3) TR33109_c0_g1_i5 Q9JYM8 SYR_NEIMB 1.00E-22 GO:0005524; GO:0004814; GO:0006420; GO:0005737 ATP binding; arginine-tRNA ligase activity; arginyl-tRNA aminoacylation; cytoplasm IPR001412; IPR001278; IPR015945; IPR005148; IPR008909; IPR014729; IPR009080; Arginine--tRNA ligase (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS) argS NMB1506 Neisseria meningitidis serogroup B (strain MC58) TR33109_c0_g2_i2 Q05506 SYRC_YEAST 1.00E-74 GO:0005524; GO:0004814; GO:0006420; GO:0005737 ATP binding; arginine-tRNA ligase activity; arginyl-tRNA aminoacylation; cytoplasm IPR001412; IPR001278; IPR015945; IPR005148; IPR008909; IPR014729; IPR009080; "Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)" YDR341C D9651.10 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33112_c0_g1_i2 Q6NWH0 CK068_DANRE 2.00E-46 IPR015034; IPR023398; UPF0696 protein C11orf68 homolog P5436 zgc:63470 Danio rerio (Zebrafish) (Brachydanio rerio) TR33112_c0_g1_i3 Q6NWH0 CK068_DANRE 7.00E-46 IPR015034; IPR023398; UPF0696 protein C11orf68 homolog P5436 zgc:63470 Danio rerio (Zebrafish) (Brachydanio rerio) TR33115_c0_g1_i2 P14381 YTX2_XENLA 1.00E-102 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR33116_c0_g3_i3 Q19425 YSPK_CAEEL 5.00E-117 GO:0006865; GO:0016021 amino acid transport; integral to membrane IPR013057; Putative amino acid permease F13H10.3 F13H10.3 Caenorhabditis elegans TR33116_c1_g1_i1 Q8QHL3 VGFR1_CHICK 8.00E-09 GO:0005524; GO:0001525; GO:0030154; GO:0006935; GO:0005768; GO:0005576; GO:0005887; GO:0018108; GO:0048010; GO:0038084; GO:0005021 ATP binding; angiogenesis; cell differentiation; chemotaxis; endosome; extracellular region; integral to plasma membrane; peptidyl-tyrosine phosphorylation; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor signaling pathway; vascular endothelial growth factor-activated receptor activity IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR001824; IPR009135; Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) FLT1 VEGFR1 Gallus gallus (Chicken) TR33116_c3_g2_i1 P79701 VGFR3_COTCO 1.00E-121 GO:0005524; GO:0001525; GO:0030154; GO:0005887; GO:0018108; GO:0048010; GO:0038084; GO:0005021 ATP binding; angiogenesis; cell differentiation; integral to plasma membrane; peptidyl-tyrosine phosphorylation; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor signaling pathway; vascular endothelial growth factor-activated receptor activity IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR001824; IPR009137; Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Endothelial kinase receptor EK2) (Quek 2) (Quek2) FLT4 K2 VEGFR3 Coturnix coturnix (Common quail) (Tetrao coturnix) TR33117_c0_g2_i1 Q9NUV9 GIMA4_HUMAN 4.00E-56 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR3312_c0_g1_i1 Q96IR2 ZN845_HUMAN 4.00E-22 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 845 ZNF845 Homo sapiens (Human) TR3312_c0_g2_i1 Q8BQN6 OZF_MOUSE 1.00E-21 GO:0003677; GO:0005737; GO:0046872; GO:0005730 DNA binding; cytoplasm; metal ion binding; nucleolus IPR007087; IPR015880; IPR013087; Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146) Znf146 Ozf Zfp146 Mus musculus (Mouse) TR3312_c0_g3_i1 Q9R0G7 ZEB2_MOUSE 5.00E-11 GO:0070412; GO:0021846; GO:0005737; GO:0021766; GO:0046872; GO:0001755; GO:0001843; GO:0005730; GO:0043507; GO:0030177; GO:0043565; GO:0003700; GO:0001756; GO:0006351 "R-SMAD binding; cell proliferation in forebrain; cytoplasm; hippocampus development; metal ion binding; neural crest cell migration; neural tube closure; nucleolus; positive regulation of JUN kinase activity; positive regulation of Wnt receptor signaling pathway; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; somitogenesis; transcription, DNA-dependent" IPR008598; IPR001356; IPR009057; IPR007087; IPR015880; IPR013087; Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (Zinc finger homeobox protein 1b) Zeb2 Sip1 Zfhx1b Zfx1b Mus musculus (Mouse) TR33120_c0_g1_i1 Q8N441 FGRL1_HUMAN 8.00E-20 GO:0060539; GO:0005007; GO:0003179; GO:0008201; GO:0016021; GO:0008285; GO:0005886; GO:0001558; GO:0001501; GO:0060412 diaphragm development; fibroblast growth factor-activated receptor activity; heart valve morphogenesis; heparin binding; integral to membrane; negative regulation of cell proliferation; plasma membrane; regulation of cell growth; skeletal system development; ventricular septum morphogenesis IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Fibroblast growth factor receptor-like 1 (FGF receptor-like protein 1) (FGF homologous factor receptor) (FGFR-like protein) (Fibroblast growth factor receptor 5) (FGFR-5) FGFRL1 FGFR5 FHFR UNQ480/PRO943 Homo sapiens (Human) TR33120_c1_g1_i1 Q7T2H2 FGRL1_CHICK 2.00E-18 GO:0060539; GO:0005007; GO:0003179; GO:0008201; GO:0016021; GO:0008285; GO:0005886; GO:0001501; GO:0060412 diaphragm development; fibroblast growth factor-activated receptor activity; heart valve morphogenesis; heparin binding; integral to membrane; negative regulation of cell proliferation; plasma membrane; skeletal system development; ventricular septum morphogenesis IPR007110; IPR013783; IPR013098; IPR003598; Fibroblast growth factor receptor-like 1 FGFRL1 Gallus gallus (Chicken) TR33122_c0_g1_i1 Q62904 DHB7_RAT 1.00E-90 GO:0000253; GO:0006695; GO:0005783; GO:0004303; GO:0006703; GO:0016021; GO:0005886; GO:0005148 3-keto sterol reductase activity; cholesterol biosynthetic process; endoplasmic reticulum; estradiol 17-beta-dehydrogenase activity; estrogen biosynthetic process; integral to membrane; plasma membrane; prolactin receptor binding IPR002198; IPR002347; IPR016040; Steroid biosynthesis; estrogen biosynthesis. Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6. 3-keto-steroid reductase (EC 1.1.1.270) (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62) (PRL receptor-associated protein) (PRAP) Hsd17b7 Rattus norvegicus (Rat) TR33123_c4_g1_i2 Q5ZIC8 IPO13_CHICK 4.00E-66 GO:0005737; GO:0005634; GO:0015031 cytoplasm; nucleus; protein transport IPR016024; IPR013598; Importin-13 (Imp13) IPO13 RCJMB04_27p9 Gallus gallus (Chicken) TR33123_c4_g1_i3 A7YWD2 IPO13_BOVIN 3.00E-33 GO:0005737; GO:0005634; GO:0006606 cytoplasm; nucleus; protein import into nucleus IPR011989; IPR016024; IPR013598; IPR001494; Importin-13 (Imp13) IPO13 Bos taurus (Bovine) TR33124_c0_g1_i3 Q6GPW2 SMO2B_XENLA 4.00E-41 GO:0005634; GO:0016925 nucleus; protein sumoylation IPR022617; IPR027218; IPR000626; Small ubiquitin-related modifier 2-B (SUMO-2-B) sumo2-b Xenopus laevis (African clawed frog) TR33127_c0_g1_i1 Q9NUS5 AP5S1_HUMAN 8.00E-09 GO:0030119; GO:0005829; GO:0000724; GO:0016197; GO:0005770; GO:0031902; GO:0005765; GO:0005764; GO:0015031 AP-type membrane coat adaptor complex; cytosol; double-strand break repair via homologous recombination; endosomal transport; late endosome; late endosome membrane; lysosomal membrane; lysosome; protein transport AP-5 complex subunit sigma-1 (Adapter-related protein complex 5 sigma subunit) (Sigma5) AP5S1 C20orf29 Homo sapiens (Human) TR33128_c0_g1_i11 P16254 SRP14_MOUSE 5.00E-25 GO:0008312; GO:0006614; GO:0030942; GO:0042493; GO:0005786 "7S RNA binding; SRP-dependent cotranslational protein targeting to membrane; endoplasmic reticulum signal peptide binding; response to drug; signal recognition particle, endoplasmic reticulum targeting" IPR003210; IPR009018; "Signal recognition particle 14 kDa protein (SRP14) [Cleaved into: Signal recognition particle 14 kDa protein, N-terminally processed]" Srp14 Mus musculus (Mouse) TR33128_c0_g1_i4 O04433 SRP14_ORYSJ 2.00E-09 GO:0008312; GO:0006614; GO:0030942; GO:0005786 "7S RNA binding; SRP-dependent cotranslational protein targeting to membrane; endoplasmic reticulum signal peptide binding; signal recognition particle, endoplasmic reticulum targeting" IPR003210; IPR009018; Signal recognition particle 14 kDa protein (SRP14) SRP14 Os04g0623700 LOC_Os04g53220 OSJNBa0053K19.10 Oryza sativa subsp. japonica (Rice) TR33128_c0_g1_i5 P16254 SRP14_MOUSE 5.00E-25 GO:0008312; GO:0006614; GO:0030942; GO:0042493; GO:0005786 "7S RNA binding; SRP-dependent cotranslational protein targeting to membrane; endoplasmic reticulum signal peptide binding; response to drug; signal recognition particle, endoplasmic reticulum targeting" IPR003210; IPR009018; "Signal recognition particle 14 kDa protein (SRP14) [Cleaved into: Signal recognition particle 14 kDa protein, N-terminally processed]" Srp14 Mus musculus (Mouse) TR33129_c1_g1_i1 E2QWQ2 NLK_CANFA 2.00E-17 GO:0005524; GO:0004707; GO:0016055; GO:0005737; GO:0000287; GO:0030178; GO:0005634; GO:0018107; GO:0046777; GO:0006355; GO:0033136; GO:0006351; GO:0007179 "ATP binding; MAP kinase activity; Wnt receptor signaling pathway; cytoplasm; magnesium ion binding; negative regulation of Wnt receptor signaling pathway; nucleus; peptidyl-threonine phosphorylation; protein autophosphorylation; regulation of transcription, DNA-dependent; serine phosphorylation of STAT3 protein; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway" IPR011009; IPR003527; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) NLK Canis familiaris (Dog) (Canis lupus familiaris) TR33129_c1_g1_i2 Q1EBK0 SSN3_COCIM 1.00E-22 GO:0005524; GO:0008353; GO:0004693; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; cyclin-dependent protein serine/threonine kinase activity; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011009; IPR000719; IPR002290; IPR008271; Serine/threonine-protein kinase SSN3 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin-dependent kinase 8) SSN3 CDK8 CIMG_00063 Coccidioides immitis (strain RS) (Valley fever fungus) TR33129_c1_g2_i1 P30285 CDK4_MOUSE 2.00E-64 GO:0005524; GO:0000082; GO:0051301; GO:0000785; GO:0000307; GO:0004693; GO:0005829; GO:0031965; GO:0005730; GO:0005654; GO:0048146; GO:0051726; GO:0042127; GO:0010468; GO:0042493; GO:0007165; GO:0005667 P24385; P25322; P06400 ATP binding; G1/S transition of mitotic cell cycle; cell division; chromatin; cyclin-dependent protein kinase holoenzyme complex; cyclin-dependent protein serine/threonine kinase activity; cytosol; nuclear membrane; nucleolus; nucleoplasm; positive regulation of fibroblast proliferation; regulation of cell cycle; regulation of cell proliferation; regulation of gene expression; response to drug; signal transduction; transcription factor complex IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 4 (EC 2.7.11.22) (CRK3) (Cell division protein kinase 4) (PSK-J3) Cdk4 Crk3 Mus musculus (Mouse) TR33129_c3_g1_i1 Q00534 CDK6_HUMAN 3.00E-31 GO:0005524; GO:0000082; GO:0007219; GO:0033077; GO:0014002; GO:0007050; GO:0043697; GO:0051301; GO:0000307; GO:0004693; GO:0005829; GO:0021542; GO:0048699; GO:0002244; GO:0060218; GO:0021670; GO:0000080; GO:2000773; GO:0050680; GO:0045638; GO:0045668; GO:0005634; GO:0001954; GO:0048146; GO:0010628; GO:2000145; GO:0045646; GO:0010468; GO:0009615; GO:0001726; GO:0003323 P24385; P30281; Q16543; P42771; P42772; P42773; P55273; Q08050-1; P08238; Q01196 ATP binding; G1/S transition of mitotic cell cycle; Notch signaling pathway; T cell differentiation in thymus; astrocyte development; cell cycle arrest; cell dedifferentiation; cell division; cyclin-dependent protein kinase holoenzyme complex; cyclin-dependent protein serine/threonine kinase activity; cytosol; dentate gyrus development; generation of neurons; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; lateral ventricle development; mitotic G1 phase; negative regulation of cellular senescence; negative regulation of epithelial cell proliferation; negative regulation of myeloid cell differentiation; negative regulation of osteoblast differentiation; nucleus; positive regulation of cell-matrix adhesion; positive regulation of fibroblast proliferation; positive regulation of gene expression; regulation of cell motility; regulation of erythrocyte differentiation; regulation of gene expression; response to virus; ruffle; type B pancreatic cell development IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) CDK6 CDKN6 Homo sapiens (Human) TR33129_c4_g1_i1 P23437 CDK2_XENLA 4.00E-18 GO:0005524; GO:0051301; GO:0004693; GO:0007067 ATP binding; cell division; cyclin-dependent protein serine/threonine kinase activity; mitosis IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 2 (EC 2.7.11.22) (CDC2 homolog Eg1 protein kinase) (Cell division protein kinase 2) cdk2 eg1 Xenopus laevis (African clawed frog) TR3313_c0_g1_i1 P07291 MLE_AEQIR 5.00E-71 GO:0005509; GO:0016459 calcium ion binding; myosin complex IPR011992; IPR002048; "Myosin essential light chain, striated adductor muscle (E-LC) (Sulfhydryl light chain) (SHLC)" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR33130_c10_g1_i1 Q96MM6 HS12B_HUMAN 8.00E-13 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR33130_c3_g1_i1 Q9CZJ2 HS12B_MOUSE 3.00E-55 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR33130_c4_g1_i1 O43301 HS12A_HUMAN 2.00E-71 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR33130_c6_g1_i1 P31396 HR3_DROME 4.00E-26 GO:0000977; GO:0004879; GO:0007552; GO:0016319; GO:0000122; GO:0005634; GO:0045944; GO:0040034; GO:0003707; GO:0004887; GO:0008270 "RNA polymerase II regulatory region sequence-specific DNA binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; metamorphosis; mushroom body development; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of development, heterochronic; steroid hormone receptor activity; thyroid hormone receptor activity; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001728; IPR001628; IPR013088; Probable nuclear hormone receptor HR3 (dHR3) (Nuclear receptor subfamily 1 group F member 4) Hr46 Hr3 NR1F4 CG11823 Drosophila melanogaster (Fruit fly) TR33130_c7_g3_i2 Q96MB7 HARB1_HUMAN 9.00E-34 GO:0005813; GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 centrosome; cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) HARBI1 C11orf77 Homo sapiens (Human) TR33135_c2_g1_i1 Q8TDD5 MCLN3_HUMAN 5.00E-20 GO:0042491; GO:0005737; GO:0016021; GO:0006811; GO:0007626; GO:0005886 auditory receptor cell differentiation; cytoplasm; integral to membrane; ion transport; locomotory behavior; plasma membrane IPR013122; Mucolipin-3 MCOLN3 Homo sapiens (Human) TR33135_c2_g1_i2 Q9GZU1 MCLN1_HUMAN 4.00E-28 GO:0006816; GO:0005261; GO:0006879; GO:0010008; GO:0005887; GO:0031902; GO:0005765; GO:0033572 calcium ion transport; cation channel activity; cellular iron ion homeostasis; endosome membrane; integral to plasma membrane; late endosome membrane; lysosomal membrane; transferrin transport IPR013122; Mucolipin-1 (MG-2) (Mucolipidin) MCOLN1 ML4 MSTP080 Homo sapiens (Human) TR33135_c2_g1_i3 Q99J21 MCLN1_MOUSE 8.00E-42 GO:0006816; GO:0005261; GO:0016197; GO:0016021; GO:0005770; GO:0031902; GO:0005765; GO:0016020; GO:0005886 calcium ion transport; cation channel activity; endosomal transport; integral to membrane; late endosome; late endosome membrane; lysosomal membrane; membrane; plasma membrane IPR013122; Mucolipin-1 (Mucolipidin) Mcoln1 Mus musculus (Mouse) TR33137_c2_g1_i1 P55212 CASP6_HUMAN 6.00E-29 GO:0006921; GO:0004197; GO:0005829; GO:0005654; GO:0006508 Itself; Q01826 cellular component disassembly involved in execution phase of apoptosis; cysteine-type endopeptidase activity; cytosol; nucleoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11] CASP6 MCH2 Homo sapiens (Human) TR33137_c2_g1_i10 Q98943 CASP2_CHICK 2.00E-35 GO:0006915; GO:0004197; GO:0005622; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; intracellular; proteolysis; regulation of apoptotic process IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) TR33137_c2_g1_i2 Q98943 CASP2_CHICK 8.00E-36 GO:0006915; GO:0004197; GO:0005622; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; intracellular; proteolysis; regulation of apoptotic process IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) TR33137_c2_g1_i3 Q08DY9 CASP3_BOVIN 6.00E-37 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Bos taurus (Bovine) TR33137_c2_g1_i4 Q60431 CASP3_MESAU 3.00E-35 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 CPP32 Mesocricetus auratus (Golden hamster) TR33137_c2_g1_i6 P55214 CASP7_MESAU 4.00E-28 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR015471; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; "Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11; Caspase-7, N-terminally processed]" CASP7 MCH3 Mesocricetus auratus (Golden hamster) TR33137_c2_g1_i7 P45436 CED3_CAERE 2.00E-30 GO:0006915; GO:0004197; GO:0005622; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; intracellular; proteolysis; regulation of apoptotic process IPR001315; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Cell death protein 3 (EC 3.4.22.-) [Cleaved into: Cell death protein 3 subunit 1; Cell death protein 3 subunit 2] ced-3 Caenorhabditis remanei (Caenorhabditis vulgaris) TR33137_c2_g1_i8 Q08DY9 CASP3_BOVIN 1.00E-38 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Bos taurus (Bovine) TR33138_c7_g2_i1 O59701 CYSK1_SCHPO 4.00E-131 GO:0006535; GO:0004124; GO:0005739; GO:0016740 cysteine biosynthetic process from serine; cysteine synthase activity; mitochondrion; transferase activity IPR001216; IPR001926; Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2. Cysteine synthase 1 (CSase 1) (EC 2.5.1.47) (O-acetylserine (thiol)-lyase 1) (OAS-TL 1) (O-acetylserine sulfhydrylase 1) cys11 cys1a SPBC36.04 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR33139_c0_g2_i1 Q58DT0 ELF5_BOVIN 1.00E-22 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; ETS-related transcription factor Elf-5 (E74-like factor 5) ELF5 Bos taurus (Bovine) TR33139_c0_g2_i2 Q01842 POK_DROME 5.00E-08 GO:0007254; GO:0007464; GO:0045467; GO:0003705; GO:0007298; GO:0001709; GO:0005737; GO:0048813; GO:0007391; GO:0006897; GO:0008406; GO:0048747; GO:0007517; GO:0046580; GO:0030178; GO:0046533; GO:0000122; GO:0005634; GO:0060233; GO:0045678; GO:0090175; GO:0045610; GO:0043565 JNK cascade; R3/R4 cell fate commitment; R7 cell development; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; border follicle cell migration; cell fate determination; cytoplasm; dendrite morphogenesis; dorsal closure; endocytosis; gonad development; muscle fiber development; muscle organ development; negative regulation of Ras protein signal transduction; negative regulation of Wnt receptor signaling pathway; negative regulation of photoreceptor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; nucleus; oenocyte delamination; positive regulation of R7 cell differentiation; regulation of establishment of planar polarity; regulation of hemocyte differentiation; sequence-specific DNA binding IPR000418; IPR003118; IPR013761; IPR011991; Ets DNA-binding protein pokkuri (Protein anterior open) (Protein yan) aop pok Yan CG3166 Drosophila melanogaster (Fruit fly) TR33139_c0_g2_i3 Q32LN0 EHF_BOVIN 2.00E-18 GO:0030855; GO:0005634; GO:0045893; GO:0043565; GO:0003700; GO:0006351 "epithelial cell differentiation; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; ETS homologous factor (ETS domain-containing transcription factor) EHF Bos taurus (Bovine) TR33139_c0_g2_i5 O95238 SPDEF_HUMAN 3.00E-12 GO:0060576; GO:0060480; GO:0007275; GO:0010454; GO:0000122; GO:0005634; GO:0043065; GO:0010455; GO:0045944; GO:0043565; GO:0003700; GO:0006351 "intestinal epithelial cell development; lung goblet cell differentiation; multicellular organismal development; negative regulation of cell fate commitment; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of apoptotic process; positive regulation of cell fate commitment; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor) SPDEF PDEF PSE Homo sapiens (Human) TR33139_c0_g2_i6 Q8VDK3 ELF5_MOUSE 2.00E-22 GO:0005737; GO:0007398; GO:0060644; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "cytoplasm; ectoderm development; mammary gland epithelial cell differentiation; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; ETS-related transcription factor Elf-5 (E74-like factor 5) Elf5 Mus musculus (Mouse) TR33139_c0_g2_i8 Q58DT0 ELF5_BOVIN 2.00E-22 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; ETS-related transcription factor Elf-5 (E74-like factor 5) ELF5 Bos taurus (Bovine) TR3314_c0_g1_i1 Q01603 PERO_DROME 8.00E-12 GO:0042600; GO:0007306; GO:0005576; GO:0020037; GO:0042744; GO:0046872; GO:0022008; GO:0004601; GO:0006909 chorion; eggshell chorion assembly; extracellular region; heme binding; hydrogen peroxide catabolic process; metal ion binding; neurogenesis; peroxidase activity; phagocytosis IPR010255; IPR002007; IPR019791; Peroxidase (DmPO) (EC 1.11.1.7) (Chorion peroxidase) Pxd HDC14047 PO CG3477 Drosophila melanogaster (Fruit fly) TR33140_c0_g1_i2 Q14728 MFS10_HUMAN 2.00E-63 GO:0006915; GO:0016021; GO:0008493; GO:0055085 apoptotic process; integral to membrane; tetracycline transporter activity; transmembrane transport IPR011701; IPR020846; IPR016196; Major facilitator superfamily domain-containing protein 10 (Tetracycline transporter-like protein) MFSD10 TETRAN Homo sapiens (Human) TR33145_c1_g1_i1 P60889 CBX7_RAT 3.00E-13 GO:0035102; GO:0016568; GO:0000792; GO:0000122; GO:0000790; GO:0003727; GO:0006351 "PRC1 complex; chromatin modification; heterochromatin; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; single-stranded RNA binding; transcription, DNA-dependent" IPR017984; IPR023780; IPR000953; IPR016197; IPR023779; Chromobox protein homolog 7 Cbx7 Rattus norvegicus (Rat) TR33146_c4_g2_i1 Q75Q39 TOM70_RAT 1.00E-102 GO:0016021; GO:0005741; GO:0015031 integral to membrane; mitochondrial outer membrane; protein transport IPR013026; IPR011990; IPR019734; Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) Tomm70a Rattus norvegicus (Rat) TR33148_c0_g1_i1 Q8JJ64 HMX3_XENLA 3.00E-21 GO:0030154; GO:0007399; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "cell differentiation; nervous system development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein HMX3 (Homeobox protein H6 family member 3) (Homeobox protein Nkx-5.1) (X-nkx-5.1) hmx3 nkx-5.1 nkx5-1 Xenopus laevis (African clawed frog) TR33148_c0_g1_i2 P56407 HM09_CAEEL 5.00E-26 GO:0007275; GO:0005634; GO:0003700; GO:0000976 multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity; transcription regulatory region sequence-specific DNA binding IPR017970; IPR001356; IPR020479; IPR009057; IPR000047; Homeobox protein ceh-9 ceh-9 Y65B4BR.9 Caenorhabditis elegans TR33148_c0_g1_i3 P42583 NKX25_XENLA 2.00E-13 GO:0007275; GO:0005634; GO:0043565; GO:0003700 multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein Nkx-2.5 (xNKx-2.5) (Homeobox protein NK-2 homolog E) nkx-2.5 Xenopus laevis (African clawed frog) TR33151_c2_g1_i2 P45447 E78C_DROME 6.00E-19 GO:0004879; GO:0005634; GO:0043565; GO:0003707; GO:0008270 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleus; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Ecdysone-induced protein 78C (DR-78) (Nuclear receptor subfamily 1 group E member 1) Eip78C NR1E1 CG18023 Drosophila melanogaster (Fruit fly) TR33151_c2_g1_i3 O77245 E75_METEN 2.00E-33 GO:0005634; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Nuclear hormone receptor E75 (Nuclear receptor subfamily 1 group D member 3) E75 NR1D3 Metapenaeus ensis (Greasyback shrimp) (Sand shrimp) TR33155_c7_g1_i1 Q8N126 CADM3_HUMAN 6.00E-15 GO:0034332; GO:0034329; GO:0005911; GO:0007157; GO:0007156; GO:0016021; GO:0005886; GO:0042803; GO:0008104 adherens junction organization; cell junction assembly; cell-cell junction; heterophilic cell-cell adhesion; homophilic cell adhesion; integral to membrane; plasma membrane; protein homodimerization activity; protein localization IPR013162; IPR007110; IPR013783; IPR003599; IPR003598; IPR013106; IPR003585; Cell adhesion molecule 3 (Brain immunoglobulin receptor) (Immunoglobulin superfamily member 4B) (IgSF4B) (Nectin-like protein 1) (NECL-1) (Synaptic cell adhesion molecule 3) (SynCAM3) (TSLC1-like protein 1) (TSLL1) CADM3 IGSF4B NECL1 SYNCAM3 TSLL1 UNQ225/PRO258 Homo sapiens (Human) TR33155_c7_g1_i2 Q66KX2 CADM4_XENLA 9.00E-08 GO:0007155; GO:0016021 cell adhesion; integral to membrane IPR013162; IPR007110; IPR013783; IPR003599; IPR003598; IPR013106; IPR003585; Cell adhesion molecule 4 (Immunoglobulin superfamily member 4C) (IgSF4C) cadm4 igsf4c Xenopus laevis (African clawed frog) TR33155_c9_g1_i1 Q2EY14 PRTGA_DANRE 5.00E-22 GO:0016021; GO:0007275 integral to membrane; multicellular organismal development IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; Protogenin A prtga Danio rerio (Zebrafish) (Brachydanio rerio) TR33155_c9_g1_i2 Q96RW7 HMCN1_HUMAN 3.00E-17 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR33156_c1_g1_i1 Q29261 VILI_PIG 2.00E-131 GO:0051015; GO:0032432; GO:0051693; GO:0030042; GO:0030041; GO:0051014; GO:0005509; GO:0071364; GO:0035729; GO:0043027; GO:0005737; GO:0060327; GO:0007173; GO:0032433; GO:0030027; GO:0035727; GO:0005902; GO:0005546; GO:0032233; GO:0010634; GO:0042803; GO:0051125; GO:0008360; GO:2000392; GO:0061041; GO:0009617; GO:0001726 "actin filament binding; actin filament bundle; actin filament capping; actin filament depolymerization; actin filament polymerization; actin filament severing; calcium ion binding; cellular response to epidermal growth factor stimulus; cellular response to hepatocyte growth factor stimulus; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; cytoplasmic actin-based contraction involved in cell motility; epidermal growth factor receptor signaling pathway; filopodium tip; lamellipodium; lysophosphatidic acid binding; microvillus; phosphatidylinositol-4,5-bisphosphate binding; positive regulation of actin filament bundle assembly; positive regulation of epithelial cell migration; protein homodimerization activity; regulation of actin nucleation; regulation of cell shape; regulation of lamellipodium morphogenesis; regulation of wound healing; response to bacterium; ruffle" IPR007123; IPR007122; IPR003128; Villin-1 VIL1 VIL Sus scrofa (Pig) TR33156_c1_g1_i2 Q5R4B6 DEMA_PONAB 5.00E-06 GO:0003779; GO:0005884; GO:0051017; GO:0051693; GO:0090527; GO:0035585; GO:0035584; GO:0031253; GO:0071320; GO:0071277; GO:0016023; GO:0005829; GO:0012505; GO:0048821; GO:0051895; GO:0033137; GO:0010801; GO:0050732; GO:0090315; GO:1900025; GO:0005634; GO:0048471; GO:0031095; GO:0030194; GO:0010763; GO:2001046; GO:1901731; GO:1900026; GO:0090303; GO:0006461; GO:0070560; GO:0043621; GO:0005102; GO:0032956; GO:0008360; GO:0051489; GO:0010591; GO:0030507; GO:0014731 actin binding; actin filament; actin filament bundle assembly; actin filament capping; actin filament reorganization; calcium-mediated signaling using extracellular calcium source; calcium-mediated signaling using intracellular calcium source; cell projection membrane; cellular response to cAMP; cellular response to calcium ion; cytoplasmic membrane-bounded vesicle; cytosol; endomembrane system; erythrocyte development; negative regulation of focal adhesion assembly; negative regulation of peptidyl-serine phosphorylation; negative regulation of peptidyl-threonine phosphorylation; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein targeting to membrane; negative regulation of substrate adhesion-dependent cell spreading; nucleus; perinuclear region of cytoplasm; platelet dense tubular network membrane; positive regulation of blood coagulation; positive regulation of fibroblast migration; positive regulation of integrin-mediated signaling pathway; positive regulation of platelet aggregation; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of wound healing; protein complex assembly; protein secretion by platelet; protein self-association; receptor binding; regulation of actin cytoskeleton organization; regulation of cell shape; regulation of filopodium assembly; regulation of lamellipodium assembly; spectrin binding; spectrin-associated cytoskeleton IPR003128; Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) DMTN EPB49 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33157_c0_g1_i1 C0HAV3 ZGPAT_SALSA 8.00E-68 GO:0046872; GO:0007175; GO:0045892; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "metal ion binding; negative regulation of epidermal growth factor-activated receptor activity; negative regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000467; IPR000571; Zinc finger CCCH-type with G patch domain-containing protein zgpat Salmo salar (Atlantic salmon) TR33157_c0_g1_i2 Q17CQ8 ZGPAT_AEDAE 3.00E-55 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000467; IPR000571; Zinc finger CCCH-type with G patch domain-containing protein AAEL004458 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR33157_c0_g1_i3 Q28H71 ZGPAT_XENTR 2.00E-43 GO:0046872; GO:0007175; GO:0045892; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "metal ion binding; negative regulation of epidermal growth factor-activated receptor activity; negative regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000467; IPR000571; Zinc finger CCCH-type with G patch domain-containing protein zgpat TEgg043k09.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33157_c0_g1_i4 Q3T045 SPF30_BOVIN 3.00E-06 GO:0015030; GO:0003723; GO:0008380; GO:0006915; GO:0005737; GO:0006397; GO:0016607; GO:0005681 Cajal body; RNA binding; RNA splicing; apoptotic process; cytoplasm; mRNA processing; nuclear speck; spliceosomal complex IPR010304; IPR002999; Survival of motor neuron-related-splicing factor 30 (Survival motor neuron domain-containing protein 1) SMNDC1 SPF30 Bos taurus (Bovine) TR33158_c0_g1_i1 Q04833 LRP_CAEEL 7.00E-17 GO:0016324; GO:0005509; GO:0005905; GO:0042395; GO:0030139; GO:0006897; GO:0016021; GO:0002119; GO:0040017; GO:0040018; GO:0030334; GO:0015248 "apical plasma membrane; calcium ion binding; coated pit; ecdysis, collagen and cuticulin-based cuticle; endocytic vesicle; endocytosis; integral to membrane; nematode larval development; positive regulation of locomotion; positive regulation of multicellular organism growth; regulation of cell migration; sterol transporter activity" IPR011042; IPR000742; IPR001881; IPR013032; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein (LRP) lrp-1 F29D11.1 Caenorhabditis elegans TR33158_c0_g1_i2 P98164 LRP2_HUMAN 8.00E-16 GO:0005794; GO:0016324; GO:0031526; GO:0005509; GO:0008283; GO:0005905; GO:0030139; GO:0005783; GO:0005768; GO:0030900; GO:0016021; GO:0005765; GO:0007603; GO:0006486; GO:0006898; GO:0001523; GO:0042359 "Golgi apparatus; apical plasma membrane; brush border membrane; calcium ion binding; cell proliferation; coated pit; endocytic vesicle; endoplasmic reticulum; endosome; forebrain development; integral to membrane; lysosomal membrane; phototransduction, visible light; protein glycosylation; receptor-mediated endocytosis; retinoid metabolic process; vitamin D metabolic process" IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; IPR019825; Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) LRP2 Homo sapiens (Human) TR33158_c0_g1_i3 P35951 LDLR_MOUSE 7.00E-14 GO:0005794; GO:0005509; GO:0009986; GO:0042632; GO:0070508; GO:0008203; GO:0005905; GO:0005769; GO:0009897; GO:0016021; GO:0030299; GO:0005770; GO:0042159; GO:0034362; GO:0030169; GO:0034383; GO:0005041; GO:0005764; GO:0015914; GO:0005886; GO:0010867; GO:0010899; GO:0030229 Golgi apparatus; calcium ion binding; cell surface; cholesterol homeostasis; cholesterol import; cholesterol metabolic process; coated pit; early endosome; external side of plasma membrane; integral to membrane; intestinal cholesterol absorption; late endosome; lipoprotein catabolic process; low-density lipoprotein particle; low-density lipoprotein particle binding; low-density lipoprotein particle clearance; low-density lipoprotein receptor activity; lysosome; phospholipid transport; plasma membrane; positive regulation of triglyceride biosynthetic process; regulation of phosphatidylcholine catabolic process; very-low-density lipoprotein particle receptor activity IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor (LDL receptor) Ldlr Mus musculus (Mouse) TR33159_c1_g1_i1 Q0VD27 ENOPH_BOVIN 9.00E-64 GO:0019509; GO:0043874; GO:0005737; GO:0000287; GO:0005634 L-methionine salvage from methylthioadenosine; acireductone synthase activity; cytoplasm; magnesium ion binding; nucleus IPR023943; IPR027511; IPR023214; IPR006439; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6. Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6. "Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase) (MASA homolog)" ENOPH1 MASA Bos taurus (Bovine) TR33160_c4_g1_i2 Q99020 ROAA_MOUSE 2.00E-32 GO:0003677; GO:0003723; GO:0005737; GO:0001837; GO:0000166; GO:0005634; GO:0045893; GO:0030529; GO:0006351 "DNA binding; RNA binding; cytoplasm; epithelial to mesenchymal transition; nucleotide binding; nucleus; positive regulation of transcription, DNA-dependent; ribonucleoprotein complex; transcription, DNA-dependent" IPR012956; IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A) Hnrnpab Cbf-a Cgbfa Hnrpab Mus musculus (Mouse) TR33160_c4_g1_i3 P07909 ROA1_DROME 3.00E-59 GO:0036099; GO:0048027; GO:0033119; GO:0000166; GO:0005634; GO:0048477; GO:0005703; GO:0045727; GO:0000381; GO:0030529; GO:0043565 "female germ-line stem cell maintenance; mRNA 5'-UTR binding; negative regulation of RNA splicing; nucleotide binding; nucleus; oogenesis; polytene chromosome puff; positive regulation of translation; regulation of alternative mRNA splicing, via spliceosome; ribonucleoprotein complex; sequence-specific DNA binding" IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (PEN repeat clone P9) (hnRNP core protein A1-A) Hrb98DE Pen9 CG9983 Drosophila melanogaster (Fruit fly) TR33163_c1_g1_i2 Q10323 IMT3_SCHPO 5.00E-42 GO:0005794; GO:0033106; GO:0007038; GO:0006897; GO:0005783; GO:0005789; GO:0016021; GO:0051999; GO:0000030; GO:0032588 Golgi apparatus; cis-Golgi network membrane; endocytosed protein transport to vacuole; endocytosis; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; mannosyl-inositol phosphorylceramide biosynthetic process; mannosyltransferase activity; trans-Golgi network membrane IPR007577; Inositol phosphoceramide mannosyltransferase 3 (EC 2.4.-.-) (IPC mannosyltransferase 3) SPAC17G8.11c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR33163_c1_g1_i3 Q10323 IMT3_SCHPO 3.00E-41 GO:0005794; GO:0033106; GO:0007038; GO:0006897; GO:0005783; GO:0005789; GO:0016021; GO:0051999; GO:0000030; GO:0032588 Golgi apparatus; cis-Golgi network membrane; endocytosed protein transport to vacuole; endocytosis; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; mannosyl-inositol phosphorylceramide biosynthetic process; mannosyltransferase activity; trans-Golgi network membrane IPR007577; Inositol phosphoceramide mannosyltransferase 3 (EC 2.4.-.-) (IPC mannosyltransferase 3) SPAC17G8.11c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR33164_c0_g1_i1 Q04656 ATP7A_HUMAN 2.00E-45 GO:0005524; GO:0042093; GO:0016323; GO:0001568; GO:0001974; GO:0031526; GO:0051216; GO:0006878; GO:0021702; GO:0030199; GO:0015677; GO:0004008; GO:0005829; GO:0048813; GO:0010273; GO:0042417; GO:0048251; GO:0051542; GO:0005783; GO:0042414; GO:0031069; GO:0001701; GO:0016021; GO:0005770; GO:0007626; GO:0048286; GO:0007005; GO:0048553; GO:0043524; GO:0043005; GO:0048812; GO:0043025; GO:0042421; GO:0042415; GO:0018205; GO:0048471; GO:0043473; GO:0048554; GO:0051353; GO:0021860; GO:0010468; GO:0002082; GO:0001836; GO:0019430; GO:0010041; GO:0010043; GO:0030141; GO:0042428; GO:0016532; GO:0005802; GO:0030140; GO:0006568; GO:0006570 Q5EBL8 ATP binding; T-helper cell differentiation; basolateral plasma membrane; blood vessel development; blood vessel remodeling; brush border membrane; cartilage development; cellular copper ion homeostasis; cerebellar Purkinje cell differentiation; collagen fibril organization; copper ion import; copper-exporting ATPase activity; cytosol; dendrite morphogenesis; detoxification of copper ion; dopamine metabolic process; elastic fiber assembly; elastin biosynthetic process; endoplasmic reticulum; epinephrine metabolic process; hair follicle morphogenesis; in utero embryonic development; integral to membrane; late endosome; locomotory behavior; lung alveolus development; mitochondrion organization; negative regulation of metalloenzyme activity; negative regulation of neuron apoptotic process; neuron projection; neuron projection morphogenesis; neuronal cell body; norepinephrine biosynthetic process; norepinephrine metabolic process; peptidyl-lysine modification; perinuclear region of cytoplasm; pigmentation; positive regulation of metalloenzyme activity; positive regulation of oxidoreductase activity; pyramidal neuron development; regulation of gene expression; regulation of oxidative phosphorylation; release of cytochrome c from mitochondria; removal of superoxide radicals; response to iron(III) ion; response to zinc ion; secretory granule; serotonin metabolic process; superoxide dismutase copper chaperone activity; trans-Golgi network; trans-Golgi network transport vesicle; tryptophan metabolic process; tyrosine metabolic process IPR023299; IPR018303; IPR008250; IPR027256; IPR001757; IPR023214; IPR017969; IPR006121; IPR006122; Copper-transporting ATPase 1 (EC 3.6.3.54) (Copper pump 1) (Menkes disease-associated protein) ATP7A MC1 MNK Homo sapiens (Human) TR33164_c1_g1_i1 O73747 FRG1_TAKRU 1.00E-72 GO:0015030; GO:0016607; GO:0006364 Cajal body; nuclear speck; rRNA processing IPR008999; IPR010414; Protein FRG1 frg1 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR33165_c2_g1_i2 Q867X0 PME3_CAEEL 4.00E-35 GO:0005975; GO:0004649 carbohydrate metabolic process; poly(ADP-ribose) glycohydrolase activity IPR007724; Poly(ADP-ribose) glycohydrolase pme-3 (EC 3.2.1.143) (Poly ADP-ribose metabolism enzyme 3) pme-3 F20C5.1 Caenorhabditis elegans TR33165_c2_g1_i3 O02776 PARG_BOVIN 1.00E-76 GO:0005975; GO:0005634; GO:0004649 carbohydrate metabolic process; nucleus; poly(ADP-ribose) glycohydrolase activity IPR007724; Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) PARG Bos taurus (Bovine) TR33165_c4_g1_i1 Q9QYM2 PARG_RAT 2.00E-33 GO:0005975; GO:0000785; GO:0003682; GO:0005634; GO:0004649; GO:0045739 carbohydrate metabolic process; chromatin; chromatin binding; nucleus; poly(ADP-ribose) glycohydrolase activity; positive regulation of DNA repair IPR007724; Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) Parg Rattus norvegicus (Rat) TR33168_c4_g1_i1 O15320 CTGE5_HUMAN 6.00E-18 GO:0008047 P00519 enzyme activator activity cTAGE family member 5 (Protein cTAGE-5) (Meningioma-expressed antigen 6/11) CTAGE5 MEA11 MEA6 MGEA11 MGEA6 Homo sapiens (Human) TR33172_c0_g2_i1 Q5BBC5 NBP35_EMENI 1.00E-80 GO:0051539; GO:0005524; GO:0005737; GO:0005506; GO:0016226; GO:0002098 "4 iron, 4 sulfur cluster binding; ATP binding; cytoplasm; iron ion binding; iron-sulfur cluster assembly; tRNA wobble uridine modification" IPR019591; IPR000808; IPR027417; Cytosolic Fe-S cluster assembly factor nbp35 (Nucleotide-binding protein 35) nbp35 AN2155 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR33173_c0_g1_i1 P24392 PEX2_RAT 2.00E-78 GO:0016593; GO:0006635; GO:0005779; GO:0050680; GO:0048147; GO:0000122; GO:0005778; GO:0031648; GO:0016558; GO:0000038; GO:0008270 Cdc73/Paf1 complex; fatty acid beta-oxidation; integral to peroxisomal membrane; negative regulation of epithelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of transcription from RNA polymerase II promoter; peroxisomal membrane; protein destabilization; protein import into peroxisome matrix; very long-chain fatty acid metabolic process; zinc ion binding IPR006845; IPR018957; IPR001841; IPR013083; IPR017907; Peroxisome biogenesis factor 2 (Peroxin-2) (Peroxisomal membrane protein 3) (Peroxisome assembly factor 1) (PAF-1) Pex2 Paf1 Pmp35 Pxmp3 Rattus norvegicus (Rat) TR33176_c4_g1_i2 Q9Y639 NPTN_HUMAN 2.00E-22 GO:0050839; GO:0007204; GO:0007156; GO:0016021; GO:0060291; GO:0045743; GO:0048170; GO:0010976; GO:0001934; GO:0042734; GO:0005105 cell adhesion molecule binding; elevation of cytosolic calcium ion concentration; homophilic cell adhesion; integral to membrane; long-term synaptic potentiation; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of long-term neuronal synaptic plasticity; positive regulation of neuron projection development; positive regulation of protein phosphorylation; presynaptic membrane; type 1 fibroblast growth factor receptor binding IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR027112; Neuroplastin (Stromal cell-derived receptor 1) (SDR-1) NPTN SDFR1 SDR1 Homo sapiens (Human) TR33176_c4_g2_i1 Q64259 VHL_RAT 7.00E-20 GO:0030891; GO:0001525; GO:0043534; GO:0005829; GO:0030198; GO:0016020; GO:0005739; GO:0000122; GO:0030182; GO:0005634; GO:0010498; GO:0051291; GO:0016567; GO:0042069; GO:0045471; GO:0001666; GO:0008134; GO:0005667 VCB complex; angiogenesis; blood vessel endothelial cell migration; cytosol; extracellular matrix organization; membrane; mitochondrion; negative regulation of transcription from RNA polymerase II promoter; neuron differentiation; nucleus; proteasomal protein catabolic process; protein heterooligomerization; protein ubiquitination; regulation of catecholamine metabolic process; response to ethanol; response to hypoxia; transcription factor binding; transcription factor complex IPR002714; IPR024048; IPR024053; IPR022772; Protein modification; protein ubiquitination. Von Hippel-Lindau disease tumor suppressor (pVHL) Vhl Rattus norvegicus (Rat) TR33179_c0_g1_i1 Q5TYP8 CA095_DANRE 2.00E-15 GO:0016021 integral to membrane IPR026673; Uncharacterized transmembrane protein C1orf95 homolog si:dkeyp-59a8.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR33180_c7_g1_i1 Q9V3L1 NDST_DROME 0 GO:0000137; GO:0000139; GO:0016055; GO:0015016; GO:0005783; GO:0007427; GO:0008543; GO:0006024; GO:0007507; GO:0015014; GO:0030210; GO:0016787; GO:0008587; GO:0007474; GO:0016021; GO:0048312; GO:0007509; GO:0007428; GO:0060828; GO:0090097; GO:0045570; GO:0007367; GO:0048488 "Golgi cis cisterna; Golgi membrane; Wnt receptor signaling pathway; [heparan sulfate]-glucosamine N-sulfotransferase activity; endoplasmic reticulum; epithelial cell migration, open tracheal system; fibroblast growth factor receptor signaling pathway; glycosaminoglycan biosynthetic process; heart development; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; heparin biosynthetic process; hydrolase activity; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein specification; integral to membrane; intracellular distribution of mitochondria; mesoderm migration involved in gastrulation; primary branching, open tracheal system; regulation of canonical Wnt receptor signaling pathway; regulation of decapentaplegic signaling pathway; regulation of imaginal disc growth; segment polarity determination; synaptic vesicle endocytosis" IPR021930; IPR027417; IPR000863; Glycan metabolism; heparan sulfate biosynthesis. Glycan metabolism; heparin biosynthesis. Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase) (Sulfateless) [Includes: Heparan sulfate N-deacetylase (EC 3.-.-.-); Heparan sulfate N-sulfotransferase (EC 2.8.2.-)] sfl CG8339 Drosophila melanogaster (Fruit fly) TR33182_c3_g1_i1 Q6AW46 EST5A_MOUSE 5.00E-78 GO:0004091; GO:0005576 carboxylesterase activity; extracellular region IPR002018; IPR019826; IPR019819; Carboxylesterase 5A (EC 3.1.1.1) (Carboxylesterase-like urinary excreted protein homolog) (Cauxin) Ces5a Ces7 Mus musculus (Mouse) TR33182_c4_g1_i1 P50162 TRN1_DATST 8.00E-41 GO:0009710; GO:0050356 tropane alkaloid biosynthetic process; tropine dehydrogenase activity IPR002198; IPR002347; IPR016040; IPR020904; Alkaloid biosynthesis; tropane alkaloid biosynthesis. Tropinone reductase 1 (EC 1.1.1.206) (Tropine dehydrogenase) (Tropinone reductase I) (TR-I) TR1 Datura stramonium (Jimsonweed) (Common thornapple) TR33182_c4_g1_i2 P80702 DIDH_COMTE 7.00E-06 GO:0047042; GO:0005737; GO:0000166 androsterone dehydrogenase (B-specific) activity; cytoplasm; nucleotide binding IPR002347; IPR016040; 3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase (3-alpha-HSD) (EC 1.1.1.50) (3-alpha-hydroxysteroid dehydrogenase/3-oxosteroid reductase) (HSD28) (Hydroxyprostaglandin dehydrogenase) hsdA Comamonas testosteroni (Pseudomonas testosteroni) TR33182_c5_g2_i1 Q7UKT5 Y9953_RHOBA 2.00E-118 IPR003846; UPF0061 protein RB9953 RB9953 Rhodopirellula baltica (strain SH1) TR33182_c5_g2_i2 Q9BVL4 SELO_HUMAN 0 IPR003846; Selenoprotein O (SelO) SELO Homo sapiens (Human) TR33183_c0_g1_i1 P48159 RL23_DROME 2.00E-62 GO:0000022; GO:0022008; GO:0005840; GO:0003735; GO:0006412 mitotic spindle elongation; neurogenesis; ribosome; structural constituent of ribosome; translation IPR019972; IPR023571; IPR000218; 60S ribosomal protein L23 (L17A) RpL23 RpL17A CG3661 Drosophila melanogaster (Fruit fly) TR33185_c4_g1_i1 Q9H4Z2 ZN335_HUMAN 1.00E-12 GO:0007420; GO:0080182; GO:0046872; GO:0048812; GO:0005634; GO:0050671; GO:0002052; GO:0040029; GO:0006355; GO:0044212; GO:0006351 "brain development; histone H3-K4 trimethylation; metal ion binding; neuron projection morphogenesis; nucleus; positive regulation of lymphocyte proliferation; positive regulation of neuroblast proliferation; regulation of gene expression, epigenetic; regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) ZNF335 Homo sapiens (Human) TR33185_c4_g2_i1 Q8N8E2 ZN513_HUMAN 3.00E-15 GO:0046872; GO:0005634; GO:0006355; GO:0050896; GO:0060041; GO:0044212; GO:0006351; GO:0007601 "metal ion binding; nucleus; regulation of transcription, DNA-dependent; response to stimulus; retina development in camera-type eye; transcription regulatory region DNA binding; transcription, DNA-dependent; visual perception" IPR007087; IPR015880; IPR013087; Zinc finger protein 513 ZNF513 Homo sapiens (Human) TR33186_c0_g1_i1 Q8NFS9 GNT2C_HUMAN 5.00E-37 GO:0000139; GO:0008109; GO:0016021; GO:0006486 "Golgi membrane; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity; integral to membrane; protein glycosylation" IPR003406; Protein modification; protein glycosylation. "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform C (N-acetylglucosaminyltransferase) (EC 2.4.1.150) (I-branching enzyme) (IGNT)" GCNT2 GCNT5 II NACGT1 Homo sapiens (Human) TR33186_c0_g1_i3 Q9P109 GCNT4_HUMAN 5.00E-20 GO:0000139; GO:0008109; GO:0016266; GO:0003829; GO:0048872; GO:0016021; GO:0002121; GO:0060993; GO:0043687; GO:0042403; GO:0048729 "Golgi membrane; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity; O-glycan processing; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; homeostasis of number of cells; integral to membrane; inter-male aggressive behavior; kidney morphogenesis; post-translational protein modification; thyroid hormone metabolic process; tissue morphogenesis" IPR003406; Protein modification; protein glycosylation. "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 (EC 2.4.1.102) (Core 2-branching enzyme 3) (Core2-GlcNAc-transferase 3) (C2GnT3)" GCNT4 Homo sapiens (Human) TR33189_c6_g1_i1 Q96RV3 PCX1_HUMAN 5.00E-84 GO:0016021 integral to membrane IPR007735; Pecanex-like protein 1 (Pecanex homolog) PCNX KIAA0805 KIAA0995 PCNXL1 Homo sapiens (Human) TR33189_c7_g1_i1 A2RUW7 PCX4_DANRE 6.00E-15 GO:0016021 integral to membrane IPR007735; Pecanex-like protein 4 pcnxl4 zgc:158219 Danio rerio (Zebrafish) (Brachydanio rerio) TR33191_c0_g1_i1 Q5F478 ANR44_CHICK 2.00E-10 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) TR33193_c1_g2_i1 Q70PU1 PGSC2_DROSI 1.00E-47 GO:0008745; GO:0005576; GO:0045087; GO:0009253; GO:0008270 N-acetylmuramoyl-L-alanine amidase activity; extracellular region; innate immune response; peptidoglycan catabolic process; zinc ion binding IPR002502; IPR017331; IPR015510; IPR006619; Peptidoglycan-recognition protein SC2 (EC 3.5.1.28) PGRP-SC2 GD10595 Drosophila simulans (Fruit fly) TR33195_c1_g1_i1 C1C4M8 MTNB_LITCT 4.00E-83 GO:0019284; GO:0019509; GO:0006915; GO:0005737; GO:0046570; GO:0008270 L-methionine biosynthetic process from S-adenosylmethionine; L-methionine salvage from methylthioadenosine; apoptotic process; cytoplasm; methylthioribulose 1-phosphate dehydratase activity; zinc ion binding IPR001303; IPR017714; IPR027514; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC 4.2.1.109) (APAF1-interacting protein homolog) apip Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) TR33195_c1_g1_i6 A8WRP9 MTNB_CAEBR 2.00E-26 GO:0019284; GO:0019509; GO:0005737; GO:0046570; GO:0008270 L-methionine biosynthetic process from S-adenosylmethionine; L-methionine salvage from methylthioadenosine; cytoplasm; methylthioribulose 1-phosphate dehydratase activity; zinc ion binding IPR001303; IPR017714; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. Probable methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC 4.2.1.109) CBG01968 Caenorhabditis briggsae TR33197_c2_g1_i3 Q9BZ19 ANR60_HUMAN 1.00E-41 IPR002110; IPR020683; IPR000626; Ankyrin repeat domain-containing protein 60 ANKRD60 C20orf86 Homo sapiens (Human) TR33199_c4_g2_i1 P33273 CP255_RAT 3.00E-84 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 2C55 (EC 1.14.14.1) (CYPIIC24) (CYPIIC55) (Cytochrome P450 2C24) (Cytochrome P450-PROS2) Cyp2c55 Cyp2c-55 Cyp2c24 Rattus norvegicus (Rat) TR33199_c4_g2_i2 O55071 CP2BJ_MOUSE 1.00E-102 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; IPR008068; Cytochrome P450 2B19 (EC 1.14.14.1) (CYPIIB19) Cyp2b19 Mus musculus (Mouse) TR33199_c4_g2_i3 O55071 CP2BJ_MOUSE 1.00E-102 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; IPR008068; Cytochrome P450 2B19 (EC 1.14.14.1) (CYPIIB19) Cyp2b19 Mus musculus (Mouse) TR33200_c1_g2_i2 Q4FZX7 SRPRB_RAT 2.00E-45 GO:0005525; GO:0016324; GO:0009925; GO:0005905; GO:0005881; GO:0005769; GO:0030139; GO:0005789; GO:0016021; GO:0005770; GO:0005739; GO:0048471; GO:0055037; GO:0007264 GTP binding; apical plasma membrane; basal plasma membrane; coated pit; cytoplasmic microtubule; early endosome; endocytic vesicle; endoplasmic reticulum membrane; integral to membrane; late endosome; mitochondrion; perinuclear region of cytoplasm; recycling endosome; small GTPase mediated signal transduction IPR027417; IPR024156; IPR019009; Signal recognition particle receptor subunit beta (SR-beta) Srprb Rattus norvegicus (Rat) TR33200_c1_g2_i3 O13950 SRPB_SCHPO 2.00E-15 GO:0005525; GO:0006614; GO:0016021; GO:0005047; GO:0005785 GTP binding; SRP-dependent cotranslational protein targeting to membrane; integral to membrane; signal recognition particle binding; signal recognition particle receptor complex IPR027417; IPR019009; Signal recognition particle receptor subunit beta (SR-beta) srp102 SPAC23H4.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR33201_c0_g1_i1 Q91W63 NRK1_MOUSE 6.00E-35 GO:0005524; GO:0009435; GO:0046872; GO:0050262 ATP binding; NAD biosynthetic process; metal ion binding; ribosylnicotinamide kinase activity IPR026681; IPR027417; Cofactor biosynthesis; NAD(+) biosynthesis. Nicotinamide riboside kinase 1 (NRK 1) (NmR-K 1) (EC 2.7.1.22) (Nicotinic acid riboside kinase 1) (EC 2.7.1.173) (Ribosylnicotinamide kinase 1) (RNK 1) (Ribosylnicotinic acid kinase 1) Nmrk1 Nrk1 Mus musculus (Mouse) TR33201_c0_g1_i3 P62511 NRK1_ASHGO 2.00E-10 GO:0005524; GO:0034356; GO:0005737; GO:0046872; GO:0046495; GO:0050262 ATP binding; NAD biosynthesis via nicotinamide riboside salvage pathway; cytoplasm; metal ion binding; nicotinamide riboside metabolic process; ribosylnicotinamide kinase activity IPR026681; IPR027417; Cofactor biosynthesis; NAD(+) biosynthesis. Nicotinamide riboside kinase (NRK) (NmR-K) (EC 2.7.1.22) (Nicotinic acid riboside kinase) (EC 2.7.1.173) (Ribosylnicotinamide kinase) (RNK) (Ribosylnicotinic acid kinase) NRK1 AGR342C Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR33201_c0_g1_i5 Q91W63 NRK1_MOUSE 3.00E-32 GO:0005524; GO:0009435; GO:0046872; GO:0050262 ATP binding; NAD biosynthetic process; metal ion binding; ribosylnicotinamide kinase activity IPR026681; IPR027417; Cofactor biosynthesis; NAD(+) biosynthesis. Nicotinamide riboside kinase 1 (NRK 1) (NmR-K 1) (EC 2.7.1.22) (Nicotinic acid riboside kinase 1) (EC 2.7.1.173) (Ribosylnicotinamide kinase 1) (RNK 1) (Ribosylnicotinic acid kinase 1) Nmrk1 Nrk1 Mus musculus (Mouse) TR33204_c0_g1_i2 Q54FW9 Y0555_DICDI 1.00E-09 IPR015943; IPR001680; IPR017986; WD repeat-containing protein DDB_G0290555 DDB_G0290555 Dictyostelium discoideum (Slime mold) TR33204_c0_g2_i1 Q6RFH5 WDR74_HUMAN 2.00E-42 GO:0016070; GO:0001825; GO:0005730 RNA metabolic process; blastocyst formation; nucleolus IPR015943; IPR001680; IPR017986; WD repeat-containing protein 74 (NOP seven-associated protein 1) WDR74 NSA1 Homo sapiens (Human) TR33205_c0_g1_i1 Q9DBV3 DHX34_MOUSE 4.00E-31 GO:0005524; GO:0008026; GO:0003723 ATP binding; ATP-dependent helicase activity; RNA binding IPR011545; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; IPR015880; Probable ATP-dependent RNA helicase DHX34 (EC 3.6.4.13) (DEAH box protein 34) Dhx34 Ddx34 Kiaa0134 Mus musculus (Mouse) TR33205_c2_g1_i1 Q9H2U1 DHX36_HUMAN 3.00E-29 GO:0005524; GO:0008026; GO:0005829; GO:0003725; GO:0045087; GO:0005634; GO:0032481; GO:0043330; GO:0009615 ATP binding; ATP-dependent helicase activity; cytosol; double-stranded RNA binding; innate immune response; nucleus; positive regulation of type I interferon production; response to exogenous dsRNA; response to virus IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Probable ATP-dependent RNA helicase DHX36 (EC 3.6.4.13) (DEAH box protein 36) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE) DHX36 DDX36 KIAA1488 MLEL1 RHAU Homo sapiens (Human) TR33205_c4_g1_i1 Q5R746 YTDC2_PONAB 5.00E-99 GO:0004386 helicase activity IPR011709; IPR007502; IPR027417; IPR007275; YTH domain-containing protein 2 YTHDC2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33205_c6_g1_i1 O60114 YG65_SCHPO 2.00E-19 GO:0005524; GO:0004003; GO:0004004; GO:0005829; GO:0003676 ATP binding; ATP-dependent DNA helicase activity; ATP-dependent RNA helicase activity; cytosol; nucleic acid binding IPR011545; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Uncharacterized helicase C15C4.05 (EC 3.6.4.-) SPBC15C4.05 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR33207_c1_g1_i1 Q3ZKN0 S27A1_BOVIN 1.00E-158 GO:0005737; GO:0012505; GO:0006631; GO:0016021; GO:0016874; GO:0006869; GO:0000166; GO:0005886 cytoplasm; endomembrane system; fatty acid metabolic process; integral to membrane; ligase activity; lipid transport; nucleotide binding; plasma membrane IPR025110; IPR020845; IPR000873; Long-chain fatty acid transport protein 1 (FATP-1) (Fatty acid transport protein 1) (EC 6.2.1.-) (Solute carrier family 27 member 1) SLC27A1 FATP1 Bos taurus (Bovine) TR33207_c1_g1_i2 O35488 S27A2_MOUSE 9.00E-107 GO:0005524; GO:0006699; GO:0005788; GO:0001561; GO:0006635; GO:0015245; GO:0030176; GO:0005779; GO:0044539; GO:0004467; GO:0097089; GO:0005739; GO:0050197; GO:0070251; GO:0042760; GO:0031957 ATP binding; bile acid biosynthetic process; endoplasmic reticulum lumen; fatty acid alpha-oxidation; fatty acid beta-oxidation; fatty acid transporter activity; integral to endoplasmic reticulum membrane; integral to peroxisomal membrane; long-chain fatty acid import; long-chain fatty acid-CoA ligase activity; methyl-branched fatty acid metabolic process; mitochondrion; phytanate-CoA ligase activity; pristanate-CoA ligase activity; very long-chain fatty acid catabolic process; very long-chain fatty acid-CoA ligase activity IPR025110; IPR020845; IPR000873; "Very long-chain acyl-CoA synthetase (VLACS) (VLCS) (EC 6.2.1.-) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 2) (THCA-CoA ligase) (Very long-chain-fatty-acid-CoA ligase)" Slc27a2 Acsvl1 Facvl1 Fatp2 Vlacs Vlcs Mus musculus (Mouse) TR33207_c1_g1_i3 Q5RDY4 S27A4_PONAB 2.00E-165 GO:0006631; GO:0016021; GO:0016874; GO:0006869; GO:0000166 fatty acid metabolic process; integral to membrane; ligase activity; lipid transport; nucleotide binding IPR025110; IPR020845; IPR000873; IPR022272; Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (EC 6.2.1.-) (Solute carrier family 27 member 4) SLC27A4 FATP4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33208_c0_g1_i1 Q3T094 ETHE1_BOVIN 5.00E-79 GO:0006749; GO:0070813; GO:0016787; GO:0005506; GO:0005759; GO:0005634; GO:0050313 glutathione metabolic process; hydrogen sulfide metabolic process; hydrolase activity; iron ion binding; mitochondrial matrix; nucleus; sulfur dioxygenase activity IPR001279; "Persulfide dioxygenase ETHE1, mitochondrial (EC 1.13.11.18) (Sulfur dioxygenase ETHE1)" ETHE1 Bos taurus (Bovine) TR33208_c0_g1_i3 Q3T094 ETHE1_BOVIN 7.00E-103 GO:0006749; GO:0070813; GO:0016787; GO:0005506; GO:0005759; GO:0005634; GO:0050313 glutathione metabolic process; hydrogen sulfide metabolic process; hydrolase activity; iron ion binding; mitochondrial matrix; nucleus; sulfur dioxygenase activity IPR001279; "Persulfide dioxygenase ETHE1, mitochondrial (EC 1.13.11.18) (Sulfur dioxygenase ETHE1)" ETHE1 Bos taurus (Bovine) TR33209_c4_g1_i1 P20825 POL2_DROME 1.00E-14 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR33210_c3_g4_i1 Q1LQ00 ADE_RALME 9.00E-10 GO:0006146; GO:0000034; GO:0043103; GO:0009117; GO:0009168; GO:0008270 adenine catabolic process; adenine deaminase activity; hypoxanthine salvage; nucleotide metabolic process; purine ribonucleoside monophosphate biosynthetic process; zinc ion binding IPR001365; IPR006330; Adenine deaminase (ADE) (EC 3.5.4.2) (Adenine aminohydrolase) (AAH) Rmet_0890 Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) TR33210_c3_g4_i2 P15287 AGSA_APLCA 5.00E-106 GO:0004000; GO:0005615; GO:0046872; GO:0009168 adenosine deaminase activity; extracellular space; metal ion binding; purine ribonucleoside monophosphate biosynthetic process IPR001365; IPR013659; IPR006331; Adenosine deaminase AGSA (EC 3.5.4.4) (Atrial gland-specific antigen) (AGSA) (Mollusk-derived growth factor) (MDGF) Aplysia californica (California sea hare) TR33210_c3_g4_i5 Q9VHH7 ADAL_DROME 1.00E-10 GO:0006154; GO:0004000; GO:0046103; GO:0046872; GO:0009117; GO:0009168 adenosine catabolic process; adenosine deaminase activity; inosine biosynthetic process; metal ion binding; nucleotide metabolic process; purine ribonucleoside monophosphate biosynthetic process IPR001365; Adenosine deaminase-like protein (EC 3.5.4.-) Ada CG11994 Drosophila melanogaster (Fruit fly) TR33210_c3_g4_i6 Q7MDL6 ADD_VIBVY 1.00E-12 GO:0004000; GO:0009117; GO:0009168; GO:0008270 adenosine deaminase activity; nucleotide metabolic process; purine ribonucleoside monophosphate biosynthetic process; zinc ion binding IPR001365; IPR006330; Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) add VVA1020 Vibrio vulnificus (strain YJ016) TR33210_c3_g4_i7 P15287 AGSA_APLCA 5.00E-106 GO:0004000; GO:0005615; GO:0046872; GO:0009168 adenosine deaminase activity; extracellular space; metal ion binding; purine ribonucleoside monophosphate biosynthetic process IPR001365; IPR013659; IPR006331; Adenosine deaminase AGSA (EC 3.5.4.4) (Atrial gland-specific antigen) (AGSA) (Mollusk-derived growth factor) (MDGF) Aplysia californica (California sea hare) TR33211_c0_g1_i1 Q80Y14 GLRX5_MOUSE 1.00E-49 GO:0051537; GO:0045454; GO:0009055; GO:0030097; GO:0046872; GO:0005739; GO:0005634; GO:0015035 "2 iron, 2 sulfur cluster binding; cell redox homeostasis; electron carrier activity; hemopoiesis; metal ion binding; mitochondrion; nucleus; protein disulfide oxidoreductase activity" IPR002109; IPR004480; IPR012336; "Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5)" Glrx5 Mus musculus (Mouse) TR33212_c0_g1_i1 O02751 CFDP2_BOVIN 2.00E-06 GO:0005737; GO:0005634 cytoplasm; nucleus IPR005135; IPR027124; Craniofacial development protein 2 (p97 bucentaur protein) CFDP2 BCNT Bos taurus (Bovine) TR33212_c10_g1_i1 O02751 CFDP2_BOVIN 3.00E-10 GO:0005737; GO:0005634 cytoplasm; nucleus IPR005135; IPR027124; Craniofacial development protein 2 (p97 bucentaur protein) CFDP2 BCNT Bos taurus (Bovine) TR33212_c9_g1_i3 Q9CZJ2 HS12B_MOUSE 1.00E-56 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR33212_c9_g1_i5 B9E6X1 DNAK_MACCJ 6.00E-06 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK MCCL_1232 Macrococcus caseolyticus (strain JCSC5402) TR33212_c9_g1_i6 Q8K0U4 HS12A_MOUSE 4.00E-77 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR33214_c2_g1_i1 Q9NSE7 ABCCD_HUMAN 2.00E-13 GO:0005524; GO:0042626; GO:0016021; GO:0005634 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; nucleus" IPR011527; IPR001140; Putative ATP-binding cassette sub-family C member 13 ABCC13 C21orf73 PRED6 Homo sapiens (Human) TR33214_c3_g2_i1 Q9FVV9 NAP5_ARATH 5.00E-41 GO:0005524; GO:0042626; GO:0016021 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; integral to membrane" IPR011527; IPR003439; IPR027417; Probable non-intrinsic ABC protein 5 (MRP-related protein 2) NAP5 At1g71330 F3I17.2 Arabidopsis thaliana (Mouse-ear cress) TR33214_c4_g1_i1 Q8RCU0 PSTB1_THETN 6.00E-13 GO:0005524; GO:0006200; GO:0015415; GO:0005886 ATP binding; ATP catabolic process; phosphate ion transmembrane-transporting ATPase activity; plasma membrane IPR003593; IPR003439; IPR017871; IPR015850; IPR027417; Phosphate import ATP-binding protein PstB 1 (EC 3.6.3.27) (ABC phosphate transporter 1) (Phosphate-transporting ATPase 1) pstB1 pstB TTE0320 Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis) TR33214_c5_g1_i2 Q8CG09 MRP1_RAT 0 GO:0005524; GO:0016323; GO:0060326; GO:0005737; GO:0043215; GO:0046618; GO:0015562; GO:0015431; GO:0034775; GO:0034634; GO:0005887; GO:0034040; GO:0005324; GO:1901215; GO:0016491; GO:0033700; GO:0015911; GO:0030335; GO:0006979; GO:0046624; GO:0008559 ATP binding; basolateral plasma membrane; cell chemotaxis; cytoplasm; daunorubicin transport; drug export; efflux transmembrane transporter activity; glutathione S-conjugate-exporting ATPase activity; glutathione transmembrane transport; glutathione transmembrane transporter activity; integral to plasma membrane; lipid-transporting ATPase activity; long-chain fatty acid transporter activity; negative regulation of neuron death; oxidoreductase activity; phospholipid efflux; plasma membrane long-chain fatty acid transport; positive regulation of cell migration; response to oxidative stress; sphingolipid transporter activity; xenobiotic-transporting ATPase activity IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR018170; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) Abcc1 Mrp1 Rattus norvegicus (Rat) TR33214_c9_g1_i1 Q8VI47 MRP2_MOUSE 2.00E-21 GO:0005524; GO:0006200; GO:0042626; GO:0016324; GO:0005887; GO:0046581 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; apical plasma membrane; integral to plasma membrane; intercellular canaliculus" IPR003593; IPR011527; IPR003439; IPR001140; IPR005292; IPR027417; Canalicular multispecific organic anion transporter 1 (ATP-binding cassette sub-family C member 2) Abcc2 Mus musculus (Mouse) TR33215_c0_g1_i1 Q5BKQ4 LIPR1_MOUSE 7.00E-67 GO:0005509; GO:0005576; GO:0006629; GO:0004806 calcium ion binding; extracellular region; lipid metabolic process; triglyceride lipase activity IPR000734; IPR008976; IPR013818; IPR002331; IPR016272; IPR001024; Inactive pancreatic lipase-related protein 1 (PL-RP1) Pnliprp1 Mus musculus (Mouse) TR33216_c0_g2_i3 Q7PCJ9 SAT2_PIG 2.00E-36 GO:0005737; GO:0004145; GO:0009447 cytoplasm; diamine N-acetyltransferase activity; putrescine catabolic process IPR016181; IPR000182; Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1. Diamine acetyltransferase 2 (EC 2.3.1.57) (Polyamine N-acetyltransferase 2) (Spermidine/spermine N(1)-acetyltransferase 2) SAT2 SSAT2 Sus scrofa (Pig) TR33217_c1_g1_i2 Q16740 CLPP_HUMAN 1.00E-85 GO:0005524; GO:0005759; GO:0005739; GO:0008233; GO:0006508; GO:0004252 ATP binding; mitochondrial matrix; mitochondrion; peptidase activity; proteolysis; serine-type endopeptidase activity IPR001907; IPR023562; IPR018215; "Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial (EC 3.4.21.92) (Endopeptidase Clp)" CLPP Homo sapiens (Human) TR33219_c0_g1_i1 A1A4M4 TATD3_BOVIN 5.00E-102 GO:0016888; GO:0046872; GO:0090305; GO:0005634 "endodeoxyribonuclease activity, producing 5'-phosphomonoesters; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleus" IPR001130; Putative deoxyribonuclease TATDN3 (EC 3.1.21.-) TATDN3 Bos taurus (Bovine) TR33220_c3_g1_i1 Q62187 TTF1_MOUSE 1.00E-06 GO:0003677; GO:0003682; GO:0006338; GO:0008156; GO:0005730; GO:0005634; GO:0006355; GO:0006363; GO:0006361 "DNA binding; chromatin binding; chromatin remodeling; negative regulation of DNA replication; nucleolus; nucleus; regulation of transcription, DNA-dependent; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter" IPR009057; IPR017877; IPR001005; Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I) (mTFF-I) Ttf1 Mus musculus (Mouse) TR33220_c3_g1_i10 Q6DG03 DMTF1_DANRE 1.00E-18 GO:0003677; GO:0007049; GO:0003682; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cell cycle; chromatin binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009057; IPR017877; IPR017930; IPR001005; Cyclin-D-binding Myb-like transcription factor 1 dmtf1 si:dkey-153k10.8 zgc:92448 Danio rerio (Zebrafish) (Brachydanio rerio) TR33220_c3_g1_i6 Q6DG03 DMTF1_DANRE 9.00E-19 GO:0003677; GO:0007049; GO:0003682; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cell cycle; chromatin binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009057; IPR017877; IPR017930; IPR001005; Cyclin-D-binding Myb-like transcription factor 1 dmtf1 si:dkey-153k10.8 zgc:92448 Danio rerio (Zebrafish) (Brachydanio rerio) TR33222_c0_g1_i1 Q28ID3 GLRX3_XENTR 3.00E-141 GO:0005938; GO:0045454; GO:0009055; GO:0015035 cell cortex; cell redox homeostasis; electron carrier activity; protein disulfide oxidoreductase activity IPR002109; IPR004480; IPR012336; IPR013766; Glutaredoxin-3 (Thioredoxin-like protein 2) glrx3 txnl2 TNeu109g06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33222_c0_g1_i2 Q1XDA3 YCF64_PORYE 4.00E-30 GO:0051537; GO:0045454; GO:0009507; GO:0009055; GO:0046872; GO:0015035 "2 iron, 2 sulfur cluster binding; cell redox homeostasis; chloroplast; electron carrier activity; metal ion binding; protein disulfide oxidoreductase activity" IPR002109; IPR014434; IPR004480; IPR012336; Uncharacterized monothiol glutaredoxin ycf64 ycf64 Pyropia yezoensis (Red alga) (Porphyra yezoensis) TR33222_c0_g1_i3 Q68W05 GLRX2_RICTY 1.00E-28 GO:0051537; GO:0045454; GO:0009055; GO:0046872; GO:0015035 "2 iron, 2 sulfur cluster binding; cell redox homeostasis; electron carrier activity; metal ion binding; protein disulfide oxidoreductase activity" IPR002109; IPR014434; IPR004480; IPR012336; Probable monothiol glutaredoxin-2 grxC2 grlA RT0730 Rickettsia typhi (strain ATCC VR-144 / Wilmington) TR33223_c0_g1_i1 Q8C2P3 DUS1L_MOUSE 0 GO:0050660; GO:0017150; GO:0002943 flavin adenine dinucleotide binding; tRNA dihydrouridine synthase activity; tRNA dihydrouridine synthesis IPR013785; IPR001269; IPR018517; tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like (EC 1.3.1.-) (tRNA-dihydrouridine synthase 1-like) Dus1l Mus musculus (Mouse) TR33224_c0_g1_i2 Q8AVP1 RPF1_XENLA 4.00E-132 GO:0003723; GO:0005730; GO:0019843; GO:0006364 RNA binding; nucleolus; rRNA binding; rRNA processing IPR004154; IPR007109; Ribosome production factor 1 (Brix domain-containing protein 5) (Ribosome biogenesis protein RPF1) rpf1 bxdc5 Xenopus laevis (African clawed frog) TR33226_c0_g3_i1 O34739 STET_BACSU 5.00E-15 GO:0015171; GO:0016021; GO:0005886 amino acid transmembrane transporter activity; integral to membrane; plasma membrane IPR002293; IPR027041; Serine/threonine exchanger SteT steT ykbA BSU12860 Bacillus subtilis (strain 168) TR33226_c0_g3_i2 Q9N1Q4 LAT2_RABIT 1.00E-82 GO:0015179; GO:0015171; GO:0016323; GO:0005737; GO:0016021; GO:0015804; GO:0015101; GO:0042605; GO:0019534 L-amino acid transmembrane transporter activity; amino acid transmembrane transporter activity; basolateral plasma membrane; cytoplasm; integral to membrane; neutral amino acid transport; organic cation transmembrane transporter activity; peptide antigen binding; toxin transporter activity IPR002293; IPR004760; Large neutral amino acids transporter small subunit 2 (4F2-LC5) (L-type amino acid transporter 2) (Solute carrier family 7 member 8) SLC7A8 LAT2 Oryctolagus cuniculus (Rabbit) TR33228_c10_g4_i2 Q95SX7 RTBS_DROME 2.00E-28 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR33228_c8_g2_i1 Q5RFV8 CB044_DANRE 6.00E-15 IPR028041; IPR015943; WD repeat-containing protein C2orf44 homolog si:dkeyp-115a10.2 zgc:103511 Danio rerio (Zebrafish) (Brachydanio rerio) TR3323_c0_g1_i1 Q6PR54 RIF1_MOUSE 3.00E-07 GO:0007049; GO:0000781; GO:0005737; GO:0001939; GO:0001940; GO:0006974; GO:0005819; GO:0019827; GO:0000723 Q80Z64; Q61066 "cell cycle; chromosome, telomeric region; cytoplasm; female pronucleus; male pronucleus; response to DNA damage stimulus; spindle; stem cell maintenance; telomere maintenance" IPR016024; IPR022031; Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) (mRif1) Rif1 Mus musculus (Mouse) TR33231_c2_g1_i1 A1A5V9 ELP5_DANRE 1.00E-30 GO:0033588; GO:0005737; GO:0005634; GO:0030335; GO:0006355; GO:0006351 "Elongator holoenzyme complex; cytoplasm; nucleus; positive regulation of cell migration; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019519; Elongator complex protein 5 (Dermal papilla-derived protein 6 homolog) (Retinoic acid-induced protein 12) elp5 derp6 Rai12 zgc:158278 zgc:158285 Danio rerio (Zebrafish) (Brachydanio rerio) TR33232_c0_g1_i2 Q29AK2 LMLN_DROPS 5.00E-31 GO:0007420; GO:0007155; GO:0051301; GO:0051298; GO:0006338; GO:0005737; GO:0008354; GO:0008406; GO:0007444; GO:0016020; GO:0046872; GO:0004222; GO:0007100; GO:0007076; GO:0007052; GO:0008233; GO:0045842; GO:0006508 brain development; cell adhesion; cell division; centrosome duplication; chromatin remodeling; cytoplasm; germ cell migration; gonad development; imaginal disc development; membrane; metal ion binding; metalloendopeptidase activity; mitotic centrosome separation; mitotic chromosome condensation; mitotic spindle organization; peptidase activity; positive regulation of mitotic metaphase/anaphase transition; proteolysis IPR001577; Leishmanolysin-like peptidase (EC 3.4.24.-) GA17800 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR33232_c0_g1_i5 O62446 LMLN_CAEEL 8.00E-29 GO:0007155; GO:0051301; GO:0005737; GO:0016020; GO:0046872; GO:0004222; GO:0007067; GO:0006508 cell adhesion; cell division; cytoplasm; membrane; metal ion binding; metalloendopeptidase activity; mitosis; proteolysis IPR001577; Leishmanolysin-like peptidase (EC 3.4.24.-) Y43F4A.1 Caenorhabditis elegans TR33234_c0_g1_i1 Q6IQT4 CSN2_DANRE 1.00E-168 GO:0008180; GO:0005737 COP9 signalosome; cytoplasm IPR013143; IPR000717; IPR011990; IPR011991; COP9 signalosome complex subunit 2 (Signalosome subunit 2) cops2 csn2 zgc:86624 Danio rerio (Zebrafish) (Brachydanio rerio) TR33234_c0_g1_i2 Q6IR75 CSN2_XENLA 4.00E-168 GO:0008180; GO:0005737 COP9 signalosome; cytoplasm IPR013143; IPR000717; IPR011990; IPR011991; COP9 signalosome complex subunit 2 (Signalosome subunit 2) (Fragment) csn2 Xenopus laevis (African clawed frog) TR33235_c1_g1_i1 P86789 GIGA6_CRAGI 1.00E-16 GO:0016021 integral to membrane IPR001466; IPR012338; Gigasin-6 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) TR33238_c3_g1_i1 Q7Z5G4 GOGA7_HUMAN 3.00E-42 GO:0000139 Golgi membrane IPR019383; Golgin subfamily A member 7 (Golgi complex-associated protein of 16 kDa) GOLGA7 GCP16 HDCKB03P HSPC041 Homo sapiens (Human) TR33240_c5_g1_i1 Q9Y6R7 FCGBP_HUMAN 9.00E-16 GO:0005737; GO:0005576 cytoplasm; extracellular region IPR003645; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) TR33240_c6_g1_i2 Q9BUT9 F195A_HUMAN 6.00E-12 Protein FAM195A FAM195A C16orf14 Homo sapiens (Human) TR33240_c7_g2_i1 Q5RC69 DCTD_PONAB 2.00E-60 GO:0004132; GO:0009165; GO:0008270 dCMP deaminase activity; nucleotide biosynthetic process; zinc ion binding IPR016192; IPR002125; IPR015517; IPR016193; IPR016473; Deoxycytidylate deaminase (EC 3.5.4.12) (dCMP deaminase) DCTD Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33240_c7_g2_i2 Q5RC69 DCTD_PONAB 2.00E-80 GO:0004132; GO:0009165; GO:0008270 dCMP deaminase activity; nucleotide biosynthetic process; zinc ion binding IPR016192; IPR002125; IPR015517; IPR016193; IPR016473; Deoxycytidylate deaminase (EC 3.5.4.12) (dCMP deaminase) DCTD Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33240_c7_g2_i3 O43012 DCTD_SCHPO 2.00E-16 GO:0005829; GO:0004132; GO:0006231; GO:0006226; GO:0005634; GO:0008270 cytosol; dCMP deaminase activity; dTMP biosynthetic process; dUMP biosynthetic process; nucleus; zinc ion binding IPR016192; IPR002125; IPR015517; IPR016193; IPR027417; Deoxycytidylate deaminase (EC 3.5.4.12) (dCMP deaminase) SPBC2G2.13c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR33240_c7_g3_i1 C3YWU0 FUCO_BRAFL 9.00E-173 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR33242_c2_g1_i1 A6QQU6 TM144_BOVIN 3.00E-112 GO:0016021 integral to membrane IPR012435; Transmembrane protein 144 TMEM144 Bos taurus (Bovine) TR33243_c1_g1_i1 O75096 LRP4_HUMAN 5.00E-26 GO:0016055; GO:0005509; GO:0030154; GO:0009953; GO:0042733; GO:0006897; GO:0030198; GO:0001942; GO:0016021; GO:0001822; GO:0090090; GO:0030279; GO:0042475; GO:0005886; GO:0009954; GO:0043113; GO:0001932; GO:0051124 Wnt receptor signaling pathway; calcium ion binding; cell differentiation; dorsal/ventral pattern formation; embryonic digit morphogenesis; endocytosis; extracellular matrix organization; hair follicle development; integral to membrane; kidney development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of ossification; odontogenesis of dentin-containing tooth; plasma membrane; proximal/distal pattern formation; receptor clustering; regulation of protein phosphorylation; synaptic growth at neuromuscular junction IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) TR33243_c1_g1_i2 P98166 VLDLR_RAT 2.00E-19 GO:0045177; GO:0005509; GO:0009986; GO:0007166; GO:0042149; GO:0071456; GO:0032869; GO:0071347; GO:0071222; GO:0021987; GO:0008203; GO:0005905; GO:0007507; GO:0016021; GO:0006869; GO:0005634; GO:0048471; GO:0030296; GO:0042493; GO:0007584; GO:0034361; GO:0034447; GO:0030229 apical part of cell; calcium ion binding; cell surface; cell surface receptor signaling pathway; cellular response to glucose starvation; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to interleukin-1; cellular response to lipopolysaccharide; cerebral cortex development; cholesterol metabolic process; coated pit; heart development; integral to membrane; lipid transport; nucleus; perinuclear region of cytoplasm; protein tyrosine kinase activator activity; response to drug; response to nutrient; very-low-density lipoprotein particle; very-low-density lipoprotein particle clearance; very-low-density lipoprotein particle receptor activity IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) Vldlr Rattus norvegicus (Rat) TR33244_c0_g1_i1 Q63100 DC1I1_RAT 3.00E-08 GO:0000777; GO:0005868; GO:0000776; GO:0005874; GO:0008017; GO:0003777; GO:0048471; GO:0000922; GO:0031982; GO:0047496 condensed chromosome kinetochore; cytoplasmic dynein complex; kinetochore; microtubule; microtubule binding; microtubule motor activity; perinuclear region of cytoplasm; spindle pole; vesicle; vesicle transport along microtubule IPR025956; IPR015943; IPR001680; IPR017986; "Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1)" Dync1i1 Dnci1 Dncic1 Rattus norvegicus (Rat) TR33244_c0_g1_i4 Q8IWG1 WDR63_HUMAN 0 IPR015943; IPR001680; IPR017986; WD repeat-containing protein 63 (Testis development protein NYD-SP29) WDR63 Homo sapiens (Human) TR33246_c2_g2_i1 Q7T163 KDIS_DANRE 1.00E-14 GO:0016021; GO:0005770; GO:0007399 integral to membrane; late endosome; nervous system development IPR002110; IPR020683; IPR011646; Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) kidins220 arms kidins220b si:dkeyp-7f8.3 si:dz119j18.2 zgc:63531 Danio rerio (Zebrafish) (Brachydanio rerio) TR33246_c2_g2_i5 Q7T163 KDIS_DANRE 8.00E-15 GO:0016021; GO:0005770; GO:0007399 integral to membrane; late endosome; nervous system development IPR002110; IPR020683; IPR011646; Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) kidins220 arms kidins220b si:dkeyp-7f8.3 si:dz119j18.2 zgc:63531 Danio rerio (Zebrafish) (Brachydanio rerio) TR33247_c1_g1_i1 Q5I0D5 LHPP_RAT 4.00E-110 GO:0005829; GO:0004427; GO:0000287; GO:0005634; GO:0008969; GO:0006470 cytosol; inorganic diphosphatase activity; magnesium ion binding; nucleus; phosphohistidine phosphatase activity; protein dephosphorylation IPR023214; IPR006357; IPR006355; IPR023215; Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (EC 3.1.3.-) (EC 3.6.1.1) Lhpp Rattus norvegicus (Rat) TR33247_c1_g1_i4 Q9D7I5 LHPP_MOUSE 2.00E-108 GO:0005829; GO:0004427; GO:0000287; GO:0005634; GO:0008969; GO:0006470 cytosol; inorganic diphosphatase activity; magnesium ion binding; nucleus; phosphohistidine phosphatase activity; protein dephosphorylation IPR023214; IPR006357; IPR006355; IPR023215; Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (EC 3.1.3.-) (EC 3.6.1.1) Lhpp Mus musculus (Mouse) TR33247_c1_g1_i5 Q5R4B4 HDHD2_PONAB 9.00E-64 GO:0046872 metal ion binding IPR023214; IPR006357; IPR006355; IPR023215; Haloacid dehalogenase-like hydrolase domain-containing protein 2 HDHD2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33248_c10_g1_i2 Q9VH19 LMLN_DROME 0 GO:0007420; GO:0007155; GO:0051301; GO:0031252; GO:0051298; GO:0006338; GO:0005737; GO:0008354; GO:0008406; GO:0007444; GO:0016020; GO:0046872; GO:0004222; GO:0007100; GO:0007076; GO:0007052; GO:0008233; GO:0045842; GO:0006508 brain development; cell adhesion; cell division; cell leading edge; centrosome duplication; chromatin remodeling; cytoplasm; germ cell migration; gonad development; imaginal disc development; membrane; metal ion binding; metalloendopeptidase activity; mitotic centrosome separation; mitotic chromosome condensation; mitotic spindle organization; peptidase activity; positive regulation of mitotic metaphase/anaphase transition; proteolysis IPR001577; Leishmanolysin-like peptidase (EC 3.4.24.-) (Invadolysin) Invadolysin l(3)IX-14 CG3953 Drosophila melanogaster (Fruit fly) TR33250_c0_g2_i1 G3UZ78 ADGB_MOUSE 2.00E-06 GO:0004198; GO:0020037; GO:0005622; GO:0005506; GO:0019825; GO:0015671; GO:0006508 calcium-dependent cysteine-type endopeptidase activity; heme binding; intracellular; iron ion binding; oxygen binding; oxygen transport; proteolysis IPR012292; IPR000048; IPR001300; Androglobin (Calpain-7-like protein) Adgb Capn7l Mus musculus (Mouse) TR33250_c3_g1_i1 G3UZ78 ADGB_MOUSE 3.00E-22 GO:0004198; GO:0020037; GO:0005622; GO:0005506; GO:0019825; GO:0015671; GO:0006508 calcium-dependent cysteine-type endopeptidase activity; heme binding; intracellular; iron ion binding; oxygen binding; oxygen transport; proteolysis IPR012292; IPR000048; IPR001300; Androglobin (Calpain-7-like protein) Adgb Capn7l Mus musculus (Mouse) TR33251_c0_g3_i1 A9ULZ2 BIR7B_XENLA 3.00E-29 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) TR33251_c0_g3_i2 Q6R7E2 IAP2_OSHVF 4.00E-16 IPR001370; Putative apoptosis inhibitor ORF87 ORF87 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) TR33252_c1_g1_i1 Q8CG47 SMC4_MOUSE 2.00E-150 GO:0005524; GO:0006310; GO:0006281; GO:0051301; GO:0000796; GO:0005737; GO:0051383; GO:0010032; GO:0045132; GO:0007076; GO:0005634; GO:0046982; GO:0007062 ATP binding; DNA recombination; DNA repair; cell division; condensin complex; cytoplasm; kinetochore organization; meiotic chromosome condensation; meiotic chromosome segregation; mitotic chromosome condensation; nucleus; protein heterodimerization activity; sister chromatid cohesion IPR027417; IPR003395; IPR024704; IPR010935; Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (XCAP-C homolog) Smc4 Capc Smc4l1 Mus musculus (Mouse) TR33252_c1_g5_i1 P50532 SMC4_XENLA 2.00E-159 GO:0005524; GO:0006310; GO:0006281; GO:0051301; GO:0005694; GO:0005829; GO:0007076; GO:0005634; GO:0046982; GO:0007062 ATP binding; DNA recombination; DNA repair; cell division; chromosome; cytosol; mitotic chromosome condensation; nucleus; protein heterodimerization activity; sister chromatid cohesion IPR027417; IPR003395; IPR024704; IPR010935; Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome assembly protein XCAP-C) (Chromosome-associated protein C) smc4 capc smc4l1 Xenopus laevis (African clawed frog) TR33253_c0_g1_i4 Q626N3 TM151_CAEBR 5.00E-11 GO:0016021 integral to membrane IPR026767; Transmembrane protein 151 homolog CBG00907 Caenorhabditis briggsae TR33256_c0_g1_i14 Q6PDF3 SVOPL_MOUSE 6.00E-09 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Putative transporter SVOPL (SVOP-like protein) Svopl Mus musculus (Mouse) TR33256_c0_g1_i15 Q9VCA2 ORCT_DROME 7.00E-127 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR33256_c0_g1_i3 Q9WTW5 S22A3_MOUSE 2.00E-80 GO:0005329; GO:0015872; GO:0051615; GO:0005887; GO:0015844; GO:0015651; GO:0032098; GO:1901998; GO:0019534 dopamine transmembrane transporter activity; dopamine transport; histamine uptake; integral to plasma membrane; monoamine transport; quaternary ammonium group transmembrane transporter activity; regulation of appetite; toxin transport; toxin transporter activity IPR020846; IPR016196; IPR004749; IPR005828; IPR005829; Solute carrier family 22 member 3 (Organic cation transporter 3) Slc22a3 Oct3 Mus musculus (Mouse) TR33256_c0_g1_i6 Q6PDF3 SVOPL_MOUSE 7.00E-09 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Putative transporter SVOPL (SVOP-like protein) Svopl Mus musculus (Mouse) TR33256_c0_g1_i7 Q9VCA2 ORCT_DROME 3.00E-127 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR33256_c0_g1_i8 Q9U539 OCT1_CAEEL 2.00E-83 GO:0016021; GO:0015101 integral to membrane; organic cation transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter 1 (CeOCT1) oct-1 F52F12.1 Caenorhabditis elegans TR33258_c1_g1_i1 Q49WS9 Y1627_STAS1 4.00E-36 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Uncharacterized oxidoreductase SSP1627 (EC 1.-.-.-) SSP1627 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) TR33258_c1_g1_i2 P14697 PHBB_CUPNH 3.00E-18 GO:0018454; GO:0005737; GO:0042619 acetoacetyl-CoA reductase activity; cytoplasm; poly-hydroxybutyrate biosynthetic process IPR011283; IPR002198; IPR002347; IPR016040; IPR020904; Biopolymer metabolism; poly-(R)-3-hydroxybutanoate biosynthesis. Acetoacetyl-CoA reductase (EC 1.1.1.36) phbB H16_A1439 Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) TR3326_c0_g1_i1 Q5SXG7 VMO1_MOUSE 2.00E-36 GO:0005576; GO:0030704 extracellular region; vitelline membrane formation IPR005515; Vitelline membrane outer layer protein 1 homolog Vmo1 Gm741 Mus musculus (Mouse) TR33261_c0_g1_i1 O35643 AP1B1_MOUSE 0 GO:0005794; GO:0030131; GO:0030665; GO:0006897; GO:0006886; GO:0008565; GO:0005802; GO:0016192 Golgi apparatus; clathrin adaptor complex; clathrin-coated vesicle membrane; endocytosis; intracellular protein transport; protein transporter activity; trans-Golgi network; vesicle-mediated transport IPR026739; IPR016342; IPR011989; IPR016024; IPR015151; IPR012295; IPR002553; IPR008152; IPR013037; IPR009028; IPR013041; AP-1 complex subunit beta-1 (Adapter-related protein complex 1 subunit beta-1) (Adaptor protein complex AP-1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) Ap1b1 Adtb1 Mus musculus (Mouse) TR33261_c0_g1_i4 O35643 AP1B1_MOUSE 0 GO:0005794; GO:0030131; GO:0030665; GO:0006897; GO:0006886; GO:0008565; GO:0005802; GO:0016192 Golgi apparatus; clathrin adaptor complex; clathrin-coated vesicle membrane; endocytosis; intracellular protein transport; protein transporter activity; trans-Golgi network; vesicle-mediated transport IPR026739; IPR016342; IPR011989; IPR016024; IPR015151; IPR012295; IPR002553; IPR008152; IPR013037; IPR009028; IPR013041; AP-1 complex subunit beta-1 (Adapter-related protein complex 1 subunit beta-1) (Adaptor protein complex AP-1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) Ap1b1 Adtb1 Mus musculus (Mouse) TR33261_c0_g1_i5 P63009 AP2B1_BOVIN 0 GO:0030131; GO:0005905; GO:0006886; GO:0005886; GO:0008565; GO:0005215; GO:0016192 clathrin adaptor complex; coated pit; intracellular protein transport; plasma membrane; protein transporter activity; transporter activity; vesicle-mediated transport IPR026739; IPR016342; IPR011989; IPR016024; IPR015151; IPR012295; IPR002553; IPR008152; IPR013037; IPR009028; IPR013041; AP-2 complex subunit beta (AP105B) (Adapter-related protein complex 2 subunit beta) (Adaptor protein complex AP-2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) AP2B1 CLAPB1 Bos taurus (Bovine) TR33262_c2_g2_i2 Q8BGI1 RNF24_MOUSE 1.00E-15 GO:0000139; GO:0016021; GO:0008270 Golgi membrane; integral to membrane; zinc ion binding IPR001841; IPR013083; RING finger protein 24 Rnf24 Mus musculus (Mouse) TR33263_c0_g3_i2 Q9D711 PIR_MOUSE 9.00E-125 GO:0005737; GO:0046872; GO:0030224; GO:0005634; GO:0008127; GO:0006355; GO:0003712; GO:0006351 "cytoplasm; metal ion binding; monocyte differentiation; nucleus; quercetin 2,3-dioxygenase activity; regulation of transcription, DNA-dependent; transcription cofactor activity; transcription, DNA-dependent" IPR012093; IPR008778; IPR003829; IPR014710; IPR011051; Flavonoid metabolism; quercetin degradation. "Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase)" Pir Mus musculus (Mouse) TR33264_c7_g1_i1 Q5KU26 COL12_HUMAN 1.00E-13 GO:0009756; GO:0005581; GO:0030666; GO:0005534; GO:0045087; GO:0016021; GO:0030169; GO:0046872; GO:0006910; GO:0005886; GO:0051260; GO:0005044; GO:0008329 "carbohydrate mediated signaling; collagen; endocytic vesicle membrane; galactose binding; innate immune response; integral to membrane; low-density lipoprotein particle binding; metal ion binding; phagocytosis, recognition; plasma membrane; protein homooligomerization; scavenger receptor activity; signaling pattern recognition receptor activity" IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-12 (Collectin placenta protein 1) (CL-P1) (hCL-P1) (Nurse cell scavenger receptor 2) (Scavenger receptor class A member 4) (Scavenger receptor with C-type lectin) COLEC12 CLP1 NSR2 SCARA4 SRCL Homo sapiens (Human) TR33264_c7_g1_i3 P02707 LECH_CHICK 7.00E-10 GO:0030246; GO:0006897; GO:0016021 carbohydrate binding; endocytosis; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; Hepatic lectin Gallus gallus (Chicken) TR33264_c7_g1_i6 Q5KU26 COL12_HUMAN 6.00E-11 GO:0009756; GO:0005581; GO:0030666; GO:0005534; GO:0045087; GO:0016021; GO:0030169; GO:0046872; GO:0006910; GO:0005886; GO:0051260; GO:0005044; GO:0008329 "carbohydrate mediated signaling; collagen; endocytic vesicle membrane; galactose binding; innate immune response; integral to membrane; low-density lipoprotein particle binding; metal ion binding; phagocytosis, recognition; plasma membrane; protein homooligomerization; scavenger receptor activity; signaling pattern recognition receptor activity" IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-12 (Collectin placenta protein 1) (CL-P1) (hCL-P1) (Nurse cell scavenger receptor 2) (Scavenger receptor class A member 4) (Scavenger receptor with C-type lectin) COLEC12 CLP1 NSR2 SCARA4 SRCL Homo sapiens (Human) TR33265_c0_g1_i1 Q9JLJ4 ELOV2_MOUSE 5.00E-74 GO:0005789; GO:0009922; GO:0034626; GO:0016021; GO:0006636; GO:0042761 "endoplasmic reticulum membrane; fatty acid elongase activity; fatty acid elongation, polyunsaturated fatty acid; integral to membrane; unsaturated fatty acid biosynthetic process; very long-chain fatty acid biosynthetic process" IPR002076; Lipid metabolism; polyunsaturated fatty acid biosynthesis. Elongation of very long chain fatty acids protein 2 (EC 2.3.1.199) (3-keto acyl-CoA synthase Elovl2) (ELOVL fatty acid elongase 2) (ELOVL FA elongase 2) (Very-long-chain 3-oxoacyl-CoA synthase 2) Elovl2 Ssc2 Mus musculus (Mouse) TR33265_c0_g1_i2 Q9EQC4 ELOV4_MOUSE 6.00E-101 GO:0019367; GO:0030176; GO:0016740; GO:0042761 "fatty acid elongation, saturated fatty acid; integral to endoplasmic reticulum membrane; transferase activity; very long-chain fatty acid biosynthetic process" IPR002076; Elongation of very long chain fatty acids protein 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase Elovl4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Very-long-chain 3-oxoacyl-CoA synthase 4) Elovl4 Mus musculus (Mouse) TR33265_c0_g1_i3 Q9JLJ4 ELOV2_MOUSE 5.00E-74 GO:0005789; GO:0009922; GO:0034626; GO:0016021; GO:0006636; GO:0042761 "endoplasmic reticulum membrane; fatty acid elongase activity; fatty acid elongation, polyunsaturated fatty acid; integral to membrane; unsaturated fatty acid biosynthetic process; very long-chain fatty acid biosynthetic process" IPR002076; Lipid metabolism; polyunsaturated fatty acid biosynthesis. Elongation of very long chain fatty acids protein 2 (EC 2.3.1.199) (3-keto acyl-CoA synthase Elovl2) (ELOVL fatty acid elongase 2) (ELOVL FA elongase 2) (Very-long-chain 3-oxoacyl-CoA synthase 2) Elovl2 Ssc2 Mus musculus (Mouse) TR33265_c0_g1_i5 Q9EQC4 ELOV4_MOUSE 6.00E-101 GO:0019367; GO:0030176; GO:0016740; GO:0042761 "fatty acid elongation, saturated fatty acid; integral to endoplasmic reticulum membrane; transferase activity; very long-chain fatty acid biosynthetic process" IPR002076; Elongation of very long chain fatty acids protein 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase Elovl4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Very-long-chain 3-oxoacyl-CoA synthase 4) Elovl4 Mus musculus (Mouse) TR33265_c0_g1_i6 Q5M8U1 ELOV5_XENTR 5.00E-74 GO:0005789; GO:0009922; GO:0016021; GO:0042761 endoplasmic reticulum membrane; fatty acid elongase activity; integral to membrane; very long-chain fatty acid biosynthetic process IPR002076; Elongation of very long chain fatty acids protein 5 (EC 2.3.1.199) (3-keto acyl-CoA synthase Elovl5) (ELOVL fatty acid elongase 5) (ELOVL FA elongase 5) (Very-long-chain 3-oxoacyl-CoA synthase 5) elovl5 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33267_c1_g1_i1 A2RU49 AGPD1_HUMAN 1.00E-39 GO:0005737; GO:0047992 cytoplasm; hydroxylysine kinase activity IPR002575; IPR011009; Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC 2.7.1.81) (Aminoglycoside phosphotransferase domain-containing protein 1) HYKK AGPHD1 Homo sapiens (Human) TR33268_c0_g1_i2 Q99J62 RFC4_MOUSE 9.00E-165 GO:0005524; GO:0003677; GO:0006260; GO:0005663; GO:0017111; GO:0005634 ATP binding; DNA binding; DNA replication; DNA replication factor C complex; nucleoside-triphosphatase activity; nucleus IPR003593; IPR003959; IPR008921; IPR027417; IPR013748; Replication factor C subunit 4 (Activator 1 subunit 4) Rfc4 Mus musculus (Mouse) TR33268_c0_g1_i3 Q99J62 RFC4_MOUSE 1.00E-164 GO:0005524; GO:0003677; GO:0006260; GO:0005663; GO:0017111; GO:0005634 ATP binding; DNA binding; DNA replication; DNA replication factor C complex; nucleoside-triphosphatase activity; nucleus IPR003593; IPR003959; IPR008921; IPR027417; IPR013748; Replication factor C subunit 4 (Activator 1 subunit 4) Rfc4 Mus musculus (Mouse) TR33269_c3_g2_i2 O95405 ZFYV9_HUMAN 0 GO:0005545; GO:0007183; GO:0007184; GO:0031901; GO:0006897; GO:0046872; GO:0030512; GO:0008236; GO:0007179 Q9Y561; P62136; P08100; Q15796; P84022; Q13277 1-phosphatidylinositol binding; SMAD protein complex assembly; SMAD protein import into nucleus; early endosome membrane; endocytosis; metal ion binding; negative regulation of transforming growth factor beta receptor signaling pathway; serine-type peptidase activity; transforming growth factor beta receptor signaling pathway IPR022557; IPR024608; IPR000306; IPR017455; IPR011011; IPR017165; IPR013083; Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) ZFYVE9 MADHIP SARA SMADIP Homo sapiens (Human) TR33270_c2_g1_i1 Q8BTH6 SCRT2_MOUSE 1.00E-07 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Transcriptional repressor scratch 2 (Scratch homolog 2 zinc finger protein) Scrt2 Mus musculus (Mouse) TR33270_c3_g1_i1 Q04652 KELC_DROME 4.00E-11 GO:0003779; GO:0030036; GO:0007349; GO:0005737; GO:0005856; GO:0007301; GO:0035183; GO:0030717; GO:0007297; GO:0030723 actin binding; actin cytoskeleton organization; cellularization; cytoplasm; cytoskeleton; female germline ring canal formation; female germline ring canal inner rim; karyosome formation; ovarian follicle cell migration; ovarian fusome organization IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR006652; Ring canal kelch protein [Cleaved into: Kelch short protein] kel CG7210 Drosophila melanogaster (Fruit fly) TR33273_c0_g1_i3 Q9CPV5 PMF1_MOUSE 2.00E-10 GO:0000444; GO:0051301; GO:0007059; GO:0007067; GO:0005634; GO:0006355; GO:0003713; GO:0006351 "MIS12/MIND type complex; cell division; chromosome segregation; mitosis; nucleus; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent" IPR007128; Polyamine-modulated factor 1 (PMF-1) Pmf1 Mus musculus (Mouse) TR33274_c0_g2_i1 Q8HXM1 CSTF2_BOVIN 4.00E-94 GO:0003723; GO:0071920; GO:0005847; GO:0006397; GO:0000166 RNA binding; cleavage body; mRNA cleavage and polyadenylation specificity factor complex; mRNA processing; nucleotide binding IPR025742; IPR026896; IPR012677; IPR000504; Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) CSTF2 Bos taurus (Bovine) TR33275_c3_g1_i1 P31686 4CL1_SOYBN 2.00E-31 GO:0016207; GO:0005524; GO:0009698 4-coumarate-CoA ligase activity; ATP binding; phenylpropanoid metabolic process IPR025110; IPR000873; "Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2." 4-coumarate--CoA ligase 1 (4CL 1) (EC 6.2.1.12) (4-coumaroyl-CoA synthase 1) (Clone 4CL14) (Fragment) Glycine max (Soybean) (Glycine hispida) TR33275_c3_g2_i1 P14913 4CL2_PETCR 9.00E-69 GO:0016207; GO:0005524; GO:0009698 4-coumarate-CoA ligase activity; ATP binding; phenylpropanoid metabolic process IPR025110; IPR020845; IPR000873; "Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2." 4-coumarate--CoA ligase 1 (4CL 1) (EC 6.2.1.12) (4-coumaroyl-CoA synthase 1) 4CL2 4CL-2 Petroselinum crispum (Parsley) (Petroselinum hortense) TR33275_c3_g2_i2 P41636 4CL_PINTA 6.00E-72 GO:0016207; GO:0005524; GO:0009698 4-coumarate-CoA ligase activity; ATP binding; phenylpropanoid metabolic process IPR025110; IPR020845; IPR000873; "Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2." 4-coumarate--CoA ligase (4CL) (EC 6.2.1.12) (4-coumaroyl-CoA synthase) 4CL Pinus taeda (Loblolly pine) TR33276_c0_g1_i1 Q62441 TLE4_MOUSE 0 GO:0003705; GO:0016055; GO:0003682; GO:0000122; GO:0005634; GO:0003714 Q62233 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; Wnt receptor signaling pathway; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription corepressor activity IPR005617; IPR009146; IPR015943; IPR001680; IPR019775; IPR017986; Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) Tle4 Grg4 Mus musculus (Mouse) TR33276_c0_g1_i2 Q08117 AES_HUMAN 9.00E-46 GO:0016055; GO:0031668; GO:0090090; GO:0032091; GO:0060761; GO:0000122; GO:0005634; GO:0009887; GO:2000210; GO:0040008; GO:0070555; GO:0001501; GO:0003714; GO:0006351 Q9Y3E5 "Wnt receptor signaling pathway; cellular response to extracellular stimulus; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of protein binding; negative regulation of response to cytokine stimulus; negative regulation of transcription from RNA polymerase II promoter; nucleus; organ morphogenesis; positive regulation of anoikis; regulation of growth; response to interleukin-1; skeletal system development; transcription corepressor activity; transcription, DNA-dependent" IPR005617; Amino-terminal enhancer of split (Amino enhancer of split) (Gp130-associated protein GAM) (Protein ESP1) (Protein GRG) AES GRG Homo sapiens (Human) TR33276_c0_g1_i3 Q9JIT3 TLE3_RAT 0 GO:0016055; GO:0005634; GO:0006355; GO:0006351 "Wnt receptor signaling pathway; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR005617; IPR009146; IPR015943; IPR001680; IPR019775; IPR017986; Transducin-like enhancer protein 3 (rTLE3) Tle3 Esp3 Rattus norvegicus (Rat) TR33276_c0_g1_i4 Q62441 TLE4_MOUSE 0 GO:0003705; GO:0016055; GO:0003682; GO:0000122; GO:0005634; GO:0003714 Q62233 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; Wnt receptor signaling pathway; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription corepressor activity IPR005617; IPR009146; IPR015943; IPR001680; IPR019775; IPR017986; Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) Tle4 Grg4 Mus musculus (Mouse) TR33276_c0_g1_i5 O42478 TLE4_XENLA 0 GO:0001707; GO:0000122; GO:0003714; GO:0006351; GO:0017053 Q25QX6 "mesoderm formation; negative regulation of transcription from RNA polymerase II promoter; transcription corepressor activity; transcription, DNA-dependent; transcriptional repressor complex" IPR005617; IPR009146; IPR015943; IPR001680; IPR019775; IPR017986; Transducin-like enhancer protein 4 (Enhancer of split groucho-like protein 2) (ESG2) (xESG2) (Grg-4) (XGrg-4) (Groucho-related protein 4) tle4 esg2 Xenopus laevis (African clawed frog) TR33276_c0_g1_i6 Q08117 AES_HUMAN 1.00E-45 GO:0016055; GO:0031668; GO:0090090; GO:0032091; GO:0060761; GO:0000122; GO:0005634; GO:0009887; GO:2000210; GO:0040008; GO:0070555; GO:0001501; GO:0003714; GO:0006351 Q9Y3E5 "Wnt receptor signaling pathway; cellular response to extracellular stimulus; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of protein binding; negative regulation of response to cytokine stimulus; negative regulation of transcription from RNA polymerase II promoter; nucleus; organ morphogenesis; positive regulation of anoikis; regulation of growth; response to interleukin-1; skeletal system development; transcription corepressor activity; transcription, DNA-dependent" IPR005617; Amino-terminal enhancer of split (Amino enhancer of split) (Gp130-associated protein GAM) (Protein ESP1) (Protein GRG) AES GRG Homo sapiens (Human) TR33277_c1_g1_i1 O43776 SYNC_HUMAN 8.00E-133 GO:0005524; GO:0004816; GO:0006421; GO:0005829; GO:0005739; GO:0003676; GO:0006418 ATP binding; asparagine-tRNA ligase activity; asparaginyl-tRNA aminoacylation; cytosol; mitochondrion; nucleic acid binding; tRNA aminoacylation for protein translation IPR004364; IPR018150; IPR006195; IPR004522; IPR002312; IPR012340; IPR004365; "Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS)" NARS Homo sapiens (Human) TR33277_c1_g2_i1 A9AYM5 SYN_HERA2 5.00E-27 GO:0005524; GO:0004816; GO:0006421; GO:0005737; GO:0003676 ATP binding; asparagine-tRNA ligase activity; asparaginyl-tRNA aminoacylation; cytoplasm; nucleic acid binding IPR004364; IPR018150; IPR006195; IPR004522; IPR002312; IPR012340; IPR004365; Asparagine--tRNA ligase (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) asnS Haur_2363 Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785) TR33277_c1_g2_i2 Q8D2U1 SYN_WIGBR 9.00E-20 GO:0005524; GO:0004816; GO:0006421; GO:0005737; GO:0003676 ATP binding; asparagine-tRNA ligase activity; asparaginyl-tRNA aminoacylation; cytoplasm; nucleic acid binding IPR004364; IPR018150; IPR006195; IPR004522; IPR002312; IPR012340; IPR004365; Asparagine--tRNA ligase (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) asnS WIGBR2630 Wigglesworthia glossinidia brevipalpis TR33277_c1_g2_i3 P41908 SYNC_SACDO 4.00E-39 GO:0005524; GO:0004816; GO:0006421; GO:0005737 ATP binding; asparagine-tRNA ligase activity; asparaginyl-tRNA aminoacylation; cytoplasm IPR004364; IPR018150; IPR004522; IPR002312; "Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (Fragment)" DED81 Saccharomyces douglasii (Yeast) TR33277_c1_g2_i4 Q038W1 SYN_LACC3 1.00E-27 GO:0005524; GO:0004816; GO:0006421; GO:0005737; GO:0003676 ATP binding; asparagine-tRNA ligase activity; asparaginyl-tRNA aminoacylation; cytoplasm; nucleic acid binding IPR004364; IPR018150; IPR006195; IPR004522; IPR002312; IPR012340; IPR004365; Asparagine--tRNA ligase (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) asnS LSEI_1485 Lactobacillus casei (strain ATCC 334) TR33278_c0_g2_i1 Q8R2H7 TRAK2_RAT 4.00E-29 GO:0050811; GO:0005769; GO:0005739; GO:0006836; GO:0005634; GO:0005886; GO:0006493; GO:0006605; GO:0006357 GABA receptor binding; early endosome; mitochondrion; neurotransmitter transport; nucleus; plasma membrane; protein O-linked glycosylation; protein targeting; regulation of transcription from RNA polymerase II promoter IPR006933; IPR022154; Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein homolog) (GABA-A receptor-interacting factor 1) (GRIF-1) (O-GlcNAc transferase-interacting protein of 98 kDa) Trak2 Als2cr3 Grif1 Oip98 Rattus norvegicus (Rat) TR33278_c1_g1_i2 Q9UPV9 TRAK1_HUMAN 2.00E-51 GO:0005769; GO:0008333; GO:0005739; GO:0005634; GO:0006493; GO:0006605; GO:0006357 Q8IXI2 early endosome; endosome to lysosome transport; mitochondrion; nucleus; protein O-linked glycosylation; protein targeting; regulation of transcription from RNA polymerase II promoter IPR006933; IPR022154; Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) TRAK1 KIAA1042 OIP106 Homo sapiens (Human) TR33283_c0_g2_i1 Q9NX74 DUS2L_HUMAN 5.00E-126 GO:0005737; GO:0003725; GO:0005783; GO:0050660; GO:0005739; GO:0060548; GO:0004860; GO:0017150; GO:0002943 cytoplasm; double-stranded RNA binding; endoplasmic reticulum; flavin adenine dinucleotide binding; mitochondrion; negative regulation of cell death; protein kinase inhibitor activity; tRNA dihydrouridine synthase activity; tRNA dihydrouridine synthesis IPR013785; IPR014720; IPR001269; IPR018517; tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.-) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2) DUS2 DUS2L Homo sapiens (Human) TR33285_c4_g1_i3 P0C0T0 LITAF_RAT 5.00E-07 GO:0005794; GO:0050699; GO:0007568; GO:0006915; GO:0005576; GO:0005765; GO:0005886; GO:0043123; GO:0006355; GO:0004871; GO:0006351 "Golgi apparatus; WW domain binding; aging; apoptotic process; extracellular region; lysosomal membrane; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of transcription, DNA-dependent; signal transducer activity; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Estrogen-enhanced transcript protein 1) (Eet-1) Litaf Rattus norvegicus (Rat) TR33286_c7_g2_i10 P22031 LEG_ANTCR 3.00E-11 GO:0030246; GO:0005737 carbohydrate binding; cytoplasm IPR000922; D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL) Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR33286_c7_g2_i2 B4HS00 LPHN_DROSE 1.00E-08 GO:0004930; GO:0030246; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; carbohydrate binding; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR000203; IPR000922; Latrophilin Cirl Cirl GM21049 Drosophila sechellia (Fruit fly) TR33286_c7_g2_i7 Q68US5 F176C_PANTR 9.00E-08 GO:0030246; GO:0016021; GO:0005886 carbohydrate binding; integral to membrane; plasma membrane IPR000922; Protein eva-1 homolog C (Protein FAM176C) EVA1C FAM176C Pan troglodytes (Chimpanzee) TR33286_c7_g2_i9 P22031 LEG_ANTCR 5.00E-11 GO:0030246; GO:0005737 carbohydrate binding; cytoplasm IPR000922; D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL) Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR33288_c1_g1_i1 Q6DJ25 MED10_XENTR 3.00E-55 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR019145; Mediator of RNA polymerase II transcription subunit 10 (Mediator complex subunit 10) med10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33289_c1_g1_i2 Q3BAI2 YCX91_PHAAO 7.00E-08 GO:0009507 chloroplast Uncharacterized protein ORF91 Phalaenopsis aphrodite subsp. formosana (Moth orchid) TR33289_c1_g2_i11 Q3BAI2 YCX91_PHAAO 3.00E-08 GO:0009507 chloroplast Uncharacterized protein ORF91 Phalaenopsis aphrodite subsp. formosana (Moth orchid) TR33290_c2_g1_i1 Q64716 INSRR_RAT 1.00E-10 GO:0005524; GO:0031532; GO:0071469; GO:0016021; GO:0030238; GO:0046777; GO:0004714; GO:0007169 ATP binding; actin cytoskeleton reorganization; cellular response to alkalinity; integral to membrane; male sex determination; protein autophosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000494; IPR003961; IPR006211; IPR006212; IPR009030; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR016246; IPR002011; Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) Insrr Rattus norvegicus (Rat) TR33290_c2_g1_i2 Q92824 PCSK5_HUMAN 0 GO:0005796; GO:0009952; GO:0007267; GO:0042089; GO:0007566; GO:0048566; GO:0048706; GO:0012505; GO:0005615; GO:0007507; GO:0016021; GO:0001822; GO:0035108; GO:0032455; GO:0048011; GO:0042277; GO:0043043; GO:0006508; GO:0002001; GO:0030323; GO:0030141; GO:0004252; GO:0006465; GO:0019058 Golgi lumen; anterior/posterior pattern specification; cell-cell signaling; cytokine biosynthetic process; embryo implantation; embryonic digestive tract development; embryonic skeletal system development; endomembrane system; extracellular space; heart development; integral to membrane; kidney development; limb morphogenesis; nerve growth factor processing; neurotrophin TRK receptor signaling pathway; peptide binding; peptide biosynthetic process; proteolysis; renin secretion into blood stream; respiratory tube development; secretory granule; serine-type endopeptidase activity; signal peptide processing; viral life cycle IPR000742; IPR006212; IPR008979; IPR009030; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5) PCSK5 PC5 PC6 Homo sapiens (Human) TR33290_c2_g1_i3 Q64716 INSRR_RAT 2.00E-10 GO:0005524; GO:0031532; GO:0071469; GO:0016021; GO:0030238; GO:0046777; GO:0004714; GO:0007169 ATP binding; actin cytoskeleton reorganization; cellular response to alkalinity; integral to membrane; male sex determination; protein autophosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000494; IPR003961; IPR006211; IPR006212; IPR009030; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR016246; IPR002011; Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) Insrr Rattus norvegicus (Rat) TR33290_c2_g1_i4 Q92824 PCSK5_HUMAN 0 GO:0005796; GO:0009952; GO:0007267; GO:0042089; GO:0007566; GO:0048566; GO:0048706; GO:0012505; GO:0005615; GO:0007507; GO:0016021; GO:0001822; GO:0035108; GO:0032455; GO:0048011; GO:0042277; GO:0043043; GO:0006508; GO:0002001; GO:0030323; GO:0030141; GO:0004252; GO:0006465; GO:0019058 Golgi lumen; anterior/posterior pattern specification; cell-cell signaling; cytokine biosynthetic process; embryo implantation; embryonic digestive tract development; embryonic skeletal system development; endomembrane system; extracellular space; heart development; integral to membrane; kidney development; limb morphogenesis; nerve growth factor processing; neurotrophin TRK receptor signaling pathway; peptide binding; peptide biosynthetic process; proteolysis; renin secretion into blood stream; respiratory tube development; secretory granule; serine-type endopeptidase activity; signal peptide processing; viral life cycle IPR000742; IPR006212; IPR008979; IPR009030; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5) PCSK5 PC5 PC6 Homo sapiens (Human) TR33290_c2_g1_i8 Q92824 PCSK5_HUMAN 0 GO:0005796; GO:0009952; GO:0007267; GO:0042089; GO:0007566; GO:0048566; GO:0048706; GO:0012505; GO:0005615; GO:0007507; GO:0016021; GO:0001822; GO:0035108; GO:0032455; GO:0048011; GO:0042277; GO:0043043; GO:0006508; GO:0002001; GO:0030323; GO:0030141; GO:0004252; GO:0006465; GO:0019058 Golgi lumen; anterior/posterior pattern specification; cell-cell signaling; cytokine biosynthetic process; embryo implantation; embryonic digestive tract development; embryonic skeletal system development; endomembrane system; extracellular space; heart development; integral to membrane; kidney development; limb morphogenesis; nerve growth factor processing; neurotrophin TRK receptor signaling pathway; peptide binding; peptide biosynthetic process; proteolysis; renin secretion into blood stream; respiratory tube development; secretory granule; serine-type endopeptidase activity; signal peptide processing; viral life cycle IPR000742; IPR006212; IPR008979; IPR009030; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5) PCSK5 PC5 PC6 Homo sapiens (Human) TR33291_c0_g2_i1 P54360 FOJO_DROME 6.00E-81 GO:0000139; GO:0007219; GO:0060071; GO:0007267; GO:0045198; GO:0001737; GO:0042067; GO:0005576; GO:0007446; GO:0016348; GO:0007474; GO:0016021; GO:0005886; GO:0004672; GO:0035159 "Golgi membrane; Notch signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway; cell-cell signaling; establishment of epithelial cell apical/basal polarity; establishment of imaginal disc-derived wing hair orientation; establishment of ommatidial planar polarity; extracellular region; imaginal disc growth; imaginal disc-derived leg joint morphogenesis; imaginal disc-derived wing vein specification; integral to membrane; plasma membrane; protein kinase activity; regulation of tube length, open tracheal system" IPR024868; "Protein four-jointed [Cleaved into: Protein four-jointed, secreted isoform]" fj CG10917 Drosophila melanogaster (Fruit fly) TR33291_c0_g2_i3 Q5ZEQ8 FJX1_XIPMA 2.00E-81 GO:0005576 extracellular region IPR009581; IPR024868; Four-jointed box protein 1 (Four-jointed protein homolog) fjx1 Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) TR33292_c2_g1_i1 Q9XUK7 NHR85_CAEEL 2.00E-20 GO:0005634; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Nuclear hormone receptor family member nhr-85 nhr-85 W05B5.3 Caenorhabditis elegans TR33292_c2_g1_i2 Q10902 NHR2_CAEEL 8.00E-16 GO:0005634; GO:0043565; GO:0003700; GO:0043401; GO:0003707; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone mediated signaling pathway; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR001628; IPR013088; Nuclear hormone receptor family member nhr-2 nhr-2 C32F10.6 Caenorhabditis elegans TR33292_c2_g1_i3 P31396 HR3_DROME 4.00E-24 GO:0000977; GO:0004879; GO:0007552; GO:0016319; GO:0000122; GO:0005634; GO:0045944; GO:0040034; GO:0003707; GO:0004887; GO:0008270 "RNA polymerase II regulatory region sequence-specific DNA binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; metamorphosis; mushroom body development; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of development, heterochronic; steroid hormone receptor activity; thyroid hormone receptor activity; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001728; IPR001628; IPR013088; Probable nuclear hormone receptor HR3 (dHR3) (Nuclear receptor subfamily 1 group F member 4) Hr46 Hr3 NR1F4 CG11823 Drosophila melanogaster (Fruit fly) TR33292_c2_g1_i4 P41828 NHR23_CAEEL 1.00E-22 GO:0018996; GO:0005634; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "molting cycle, collagen and cuticulin-based cuticle; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Nuclear hormone receptor family member nhr-23 (Steroid hormone receptor family member chr-3) nhr-23 chr-3 C01H6.5 Caenorhabditis elegans TR33292_c2_g3_i2 O13124 VDR_XENLA 3.00E-16 GO:0008434; GO:0005634; GO:0043565; GO:0003707; GO:0070561; GO:0008270 calcitriol receptor activity; nucleus; sequence-specific DNA binding; steroid hormone receptor activity; vitamin D receptor signaling pathway; zinc ion binding IPR008946; IPR000536; IPR001723; IPR000324; IPR001628; IPR013088; "Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1)" vdr nr1i1 Xenopus laevis (African clawed frog) TR33293_c0_g1_i1 O08863 BIRC3_MOUSE 5.00E-14 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 P39429 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Inhibitor of apoptosis protein 1) (IAP-1) (mIAP-1) (mIAP1) Birc3 Birc2 Iap1 Mus musculus (Mouse) TR33293_c0_g1_i2 A9JTP3 BIRC7_XENTR 3.00E-13 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP) (Embryonic/Egg IAP) (EIAP/XLX) birc7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33293_c0_g1_i3 Q9NR09 BIRC6_HUMAN 5.00E-14 GO:0005794; GO:0006915; GO:0051301; GO:0004869; GO:0005768; GO:0060711; GO:0016020; GO:0005815; GO:0030496; GO:0007067; GO:0043066; GO:2001237; GO:0008284; GO:0006468; GO:0042127; GO:0032465; GO:0000922; GO:0060712; GO:0005802; GO:0004842 Q96A65; Q02241; Q02750; P53350 Golgi apparatus; apoptotic process; cell division; cysteine-type endopeptidase inhibitor activity; endosome; labyrinthine layer development; membrane; microtubule organizing center; midbody; mitosis; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; positive regulation of cell proliferation; protein phosphorylation; regulation of cell proliferation; regulation of cytokinesis; spindle pole; spongiotrophoblast layer development; trans-Golgi network; ubiquitin-protein ligase activity IPR001370; IPR022103; IPR000608; IPR016135; IPR015943; Baculoviral IAP repeat-containing protein 6 (EC 6.3.2.-) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) BIRC6 KIAA1289 Homo sapiens (Human) TR33293_c0_g1_i4 Q9JHY7 BIRC5_RAT 6.00E-40 GO:0000086; GO:0016324; GO:0005814; GO:0032133; GO:0007059; GO:0048037; GO:0000777; GO:0043027; GO:0000910; GO:0005881; GO:0005829; GO:0051303; GO:0031021; GO:0008017; GO:0030496; GO:0007067; GO:0043066; GO:0045892; GO:0005634; GO:0031536; GO:0045931; GO:0031503; GO:0042803; GO:0006468; GO:0042493; GO:0051384; GO:0043434; GO:0031577; GO:0005876; GO:0006351; GO:0008270 "G2/M transition of mitotic cell cycle; apical plasma membrane; centriole; chromosome passenger complex; chromosome segregation; cofactor binding; condensed chromosome kinetochore; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytokinesis; cytoplasmic microtubule; cytosol; establishment of chromosome localization; interphase microtubule organizing center; microtubule binding; midbody; mitosis; negative regulation of apoptotic process; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of exit from mitosis; positive regulation of mitotic cell cycle; protein complex localization; protein homodimerization activity; protein phosphorylation; response to drug; response to glucocorticoid stimulus; response to peptide hormone stimulus; spindle checkpoint; spindle microtubule; transcription, DNA-dependent; zinc ion binding" IPR001370; Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) Birc5 Rattus norvegicus (Rat) TR33294_c0_g1_i1 P60522 GBRL2_RAT 1.00E-52 GO:0005794; GO:0005776; GO:0000421; GO:0006914; GO:0031410; GO:1901799; GO:0015031 Golgi apparatus; autophagic vacuole; autophagic vacuole membrane; autophagy; cytoplasmic vesicle; negative regulation of proteasomal protein catabolic process; protein transport IPR004241; Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) Gabarapl2 Gef2 Rattus norvegicus (Rat) TR33298_c0_g1_i3 B5X0W9 ISOC1_SALSA 6.00E-79 GO:0003824 catalytic activity IPR000868; Isochorismatase domain-containing protein 1 isoc1 Salmo salar (Atlantic salmon) TR3330_c0_g1_i1 O75330 HMMR_HUMAN 2.00E-11 GO:0005975; GO:0009986; GO:0005737; GO:0030214; GO:0005540; GO:0005886; GO:0044281 carbohydrate metabolic process; cell surface; cytoplasm; hyaluronan catabolic process; hyaluronic acid binding; plasma membrane; small molecule metabolic process IPR026203; Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168) HMMR IHABP RHAMM Homo sapiens (Human) TR33301_c1_g1_i1 Q96L58 B3GT6_HUMAN 7.00E-90 GO:0032580; GO:0005797; GO:0000139; GO:0008499; GO:0035250; GO:0005975; GO:0030206; GO:0030204; GO:0047220; GO:0006024; GO:0015012; GO:0016021; GO:0006486 "Golgi cisterna membrane; Golgi medial cisterna; Golgi membrane; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; UDP-galactosyltransferase activity; carbohydrate metabolic process; chondroitin sulfate biosynthetic process; chondroitin sulfate metabolic process; galactosylxylosylprotein 3-beta-galactosyltransferase activity; glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process; integral to membrane; protein glycosylation" IPR002659; Glycan metabolism; chondroitin sulfate biosynthesis. Glycan metabolism; heparan sulfate biosynthesis. "Beta-1,3-galactosyltransferase 6 (Beta-1,3-GalTase 6) (Beta3Gal-T6) (Beta3GalT6) (EC 2.4.1.134) (GAG GalTII) (Galactosyltransferase II) (Galactosylxylosylprotein 3-beta-galactosyltransferase) (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6)" B3GALT6 Homo sapiens (Human) TR33301_c1_g1_i2 Q9SAA4 B3GT1_ARATH 1.00E-18 GO:0000139; GO:0008378; GO:0016021; GO:0006486 Golgi membrane; galactosyltransferase activity; integral to membrane; protein glycosylation IPR025298; IPR002659; Protein modification; protein glycosylation. "Probable beta-1,3-galactosyltransferase 1 (EC 2.4.1.-)" B3GALT1 At1g11730 F25C20.12 Arabidopsis thaliana (Mouse-ear cress) TR33301_c1_g1_i3 Q6NRQ1 B3GL2_XENLA 4.00E-21 GO:0000139; GO:0008376; GO:0008375; GO:0005783; GO:0008378; GO:0016021; GO:0006493 Golgi membrane; acetylgalactosaminyltransferase activity; acetylglucosaminyltransferase activity; endoplasmic reticulum; galactosyltransferase activity; integral to membrane; protein O-linked glycosylation IPR002659; Protein modification; protein glycosylation. "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 (Beta-1,3-GalNAc-T2) (EC 2.4.1.-) (Beta-1,3-N-acetylgalactosaminyltransferase II)" b3galnt2 Xenopus laevis (African clawed frog) TR33301_c1_g1_i4 Q91Z92 B3GT6_MOUSE 6.00E-91 GO:0005797; GO:0000139; GO:0008499; GO:0030206; GO:0047220; GO:0006024; GO:0015012; GO:0016021; GO:0006486 "Golgi medial cisterna; Golgi membrane; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; chondroitin sulfate biosynthetic process; galactosylxylosylprotein 3-beta-galactosyltransferase activity; glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process; integral to membrane; protein glycosylation" IPR002659; Glycan metabolism; chondroitin sulfate biosynthesis. Glycan metabolism; heparan sulfate biosynthesis. "Beta-1,3-galactosyltransferase 6 (Beta-1,3-GalTase 6) (Beta3Gal-T6) (Beta3GalT6) (EC 2.4.1.134) (GAG GalTII) (Galactosyltransferase II) (Galactosylxylosylprotein 3-beta-galactosyltransferase) (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6)" B3galt6 Mus musculus (Mouse) TR33303_c1_g1_i4 Q62737 CY24A_RAT 5.00E-32 GO:0005794; GO:0043020; GO:0016324; GO:0071230; GO:0071480; GO:0071333; GO:0071260; GO:0071407; GO:0071356; GO:0017004; GO:0030425; GO:0009055; GO:0020037; GO:0050665; GO:0006954; GO:0045087; GO:0046872; GO:0005739; GO:0003106; GO:0043025; GO:0055114; GO:0030307; GO:0001938; GO:0045730; GO:0042493; GO:0070555; GO:0031667; GO:0014895; GO:0042554; GO:0016175 Golgi apparatus; NADPH oxidase complex; apical plasma membrane; cellular response to amino acid stimulus; cellular response to gamma radiation; cellular response to glucose stimulus; cellular response to mechanical stimulus; cellular response to organic cyclic compound; cellular response to tumor necrosis factor; cytochrome complex assembly; dendrite; electron carrier activity; heme binding; hydrogen peroxide biosynthetic process; inflammatory response; innate immune response; metal ion binding; mitochondrion; negative regulation of glomerular filtration by angiotensin; neuronal cell body; oxidation-reduction process; positive regulation of cell growth; positive regulation of endothelial cell proliferation; respiratory burst; response to drug; response to interleukin-1; response to nutrient levels; smooth muscle hypertrophy; superoxide anion generation; superoxide-generating NADPH oxidase activity IPR007732; Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox) (p22phox) Cyba Rattus norvegicus (Rat) TR33305_c4_g1_i1 P55541 Y4LA_RHISN 6.00E-29 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Uncharacterized short-chain type dehydrogenase/reductase y4lA (EC 1.-.-.-) NGR_a02730 y4lA Rhizobium sp. (strain NGR234) TR33305_c4_g1_i2 Q99LB2 DHRS4_MOUSE 6.00E-87 GO:0004090; GO:0005739; GO:0005777; GO:0001758; GO:0042574 carbonyl reductase (NADPH) activity; mitochondrion; peroxisome; retinal dehydrogenase activity; retinal metabolic process IPR002198; IPR002347; IPR016040; IPR020904; Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (mouNRDR) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) Dhrs4 D14Ucla2 Mus musculus (Mouse) TR33306_c0_g1_i1 P53011 SEH1_YEAST 8.00E-57 GO:0035859; GO:0000329; GO:0051028; GO:0031080; GO:0006913; GO:0005886; GO:0015031; GO:0017056 P46673 Seh1-associated complex; fungal-type vacuole membrane; mRNA transport; nuclear pore outer ring; nucleocytoplasmic transport; plasma membrane; protein transport; structural constituent of nuclear pore IPR015943; IPR001680; IPR017986; Nucleoporin SEH1 (Nuclear pore protein SEH1) (SEC13 homolog 1) SEH1 YGL100W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33306_c0_g2_i2 A7YY75 SEH1_BOVIN 1.00E-162 GO:0051315; GO:0051301; GO:0000777; GO:0051028; GO:0007080; GO:0006999; GO:0031080; GO:0015031 attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation; cell division; condensed chromosome kinetochore; mRNA transport; mitotic metaphase plate congression; nuclear pore organization; nuclear pore outer ring; protein transport IPR020472; IPR015943; IPR001680; IPR017986; Nucleoporin SEH1 (Nup107-160 subcomplex subunit SEH1) SEH1L Bos taurus (Bovine) TR33307_c0_g1_i1 Q5E9K7 CCNE2_BOVIN 1.00E-07 GO:0006270; GO:0007049; GO:0051301; GO:0016538; GO:0005634; GO:0000079 DNA replication initiation; cell cycle; cell division; cyclin-dependent protein serine/threonine kinase regulator activity; nucleus; regulation of cyclin-dependent protein serine/threonine kinase activity IPR013763; IPR014400; IPR004367; IPR006671; G1/S-specific cyclin-E2 CCNE2 Bos taurus (Bovine) TR33307_c0_g1_i2 Q9Z2V9 CCNI_MOUSE 2.00E-62 GO:0016538; GO:0051726 cyclin-dependent protein serine/threonine kinase regulator activity; regulation of cell cycle IPR013763; IPR006671; Cyclin-I Ccni Mus musculus (Mouse) TR33309_c0_g1_i1 Q5R8L2 BMI1_PONAB 1.00E-83 GO:0031519; GO:0016568; GO:0005737; GO:0030890; GO:0033092; GO:0051443; GO:0006355; GO:0006351; GO:0000151; GO:0008270 "PcG protein complex; chromatin modification; cytoplasm; positive regulation of B cell proliferation; positive regulation of immature T cell proliferation in thymus; positive regulation of ubiquitin-protein ligase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin ligase complex; zinc ion binding" IPR018957; IPR001841; IPR013083; IPR017907; Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) BMI1 PCGF4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33311_c3_g2_i2 Q71U00 SKP1_XENLA 4.00E-44 GO:0019005; GO:0016567; GO:0006511 SCF ubiquitin ligase complex; protein ubiquitination; ubiquitin-dependent protein catabolic process IPR011333; IPR016897; IPR001232; IPR016072; IPR016073; Protein modification; protein ubiquitination. S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1) skp1 skp1a Xenopus laevis (African clawed frog) TR33311_c3_g2_i5 Q71U00 SKP1_XENLA 3.00E-47 GO:0019005; GO:0016567; GO:0006511 SCF ubiquitin ligase complex; protein ubiquitination; ubiquitin-dependent protein catabolic process IPR011333; IPR016897; IPR001232; IPR016072; IPR016073; Protein modification; protein ubiquitination. S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1) skp1 skp1a Xenopus laevis (African clawed frog) TR33312_c1_g1_i1 P13584 CP4B1_HUMAN 2.00E-80 GO:0070330; GO:0018879; GO:0008144; GO:0005789; GO:0042738; GO:0018917; GO:0018585; GO:0020037; GO:0005506; GO:0019825; GO:0044281; GO:0006805 aromatase activity; biphenyl metabolic process; drug binding; endoplasmic reticulum membrane; exogenous drug catabolic process; fluorene metabolic process; fluorene oxygenase activity; heme binding; iron ion binding; oxygen binding; small molecule metabolic process; xenobiotic metabolic process IPR001128; IPR017972; IPR002401; Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (Cytochrome P450-HP) CYP4B1 Homo sapiens (Human) TR33312_c1_g1_i2 Q8N1L4 CP4Z2_HUMAN 3.00E-21 GO:0020037; GO:0016021; GO:0005506; GO:0016705 "heme binding; integral to membrane; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; Putative inactive cytochrome P450 family member 4Z2 CYP4Z2P Homo sapiens (Human) TR33312_c1_g1_i3 P15129 CP4B1_RAT 9.00E-83 GO:0070330; GO:0018879; GO:0008144; GO:0005789; GO:0042738; GO:0018917; GO:0018585; GO:0020037; GO:0043231; GO:0005506; GO:0004497 aromatase activity; biphenyl metabolic process; drug binding; endoplasmic reticulum membrane; exogenous drug catabolic process; fluorene metabolic process; fluorene oxygenase activity; heme binding; intracellular membrane-bounded organelle; iron ion binding; monooxygenase activity IPR001128; IPR017972; IPR002401; Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (Cytochrome P450 L-2) (Cytochrome P450 isozyme 5) Cyp4b1 Cyp4b-1 Rattus norvegicus (Rat) TR33312_c1_g1_i4 Q28827 CP11A_RABIT 9.00E-10 GO:0006700; GO:0008203; GO:0008386; GO:0020037; GO:0005506; GO:0031966 C21-steroid hormone biosynthetic process; cholesterol metabolic process; cholesterol monooxygenase (side-chain-cleaving) activity; heme binding; iron ion binding; mitochondrial membrane IPR001128; IPR002399; Lipid metabolism; C21-steroid hormone metabolism. "Cholesterol side-chain cleavage enzyme, mitochondrial (EC 1.14.15.6) (CYPXIA1) (Cholesterol desmolase) (Cytochrome P450 11A1) (Cytochrome P450(scc)) (Fragment)" CYP11A1 Oryctolagus cuniculus (Rabbit) TR33320_c2_g1_i1 O18373 SPS1_DROME 0 GO:0005524; GO:0007049; GO:0008283; GO:0006541; GO:0007444; GO:0016301; GO:0007005; GO:2000378; GO:0022008; GO:0008284; GO:0016260 Q8MYW5; Q8MTA1; P07665 ATP binding; cell cycle; cell proliferation; glutamine metabolic process; imaginal disc development; kinase activity; mitochondrion organization; negative regulation of reactive oxygen species metabolic process; neurogenesis; positive regulation of cell proliferation; selenocysteine biosynthetic process IPR010918; IPR000728; IPR016188; IPR004536; "Selenide, water dikinase (EC 2.7.9.3) (Protein patufet) (Selenium donor protein) (Selenophosphate synthase) (dSelD)" SelD PTF1 ptuf CG8553 Drosophila melanogaster (Fruit fly) TR33320_c2_g1_i4 B2RLG7 SELD_PORG3 4.00E-36 GO:0005524; GO:0000287; GO:0004756; GO:0016260 "ATP binding; magnesium ion binding; selenide, water dikinase activity; selenocysteine biosynthetic process" IPR010918; IPR000728; IPR016188; IPR004536; IPR023061; "Selenide, water dikinase (EC 2.7.9.3) (Selenium donor protein) (Selenophosphate synthase)" selD PGN_1693 Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) TR33321_c3_g1_i2 P54116 STOM_MOUSE 5.00E-52 GO:0005856; GO:0070062; GO:0005887; GO:0042470; GO:0045121; GO:0051260 Itself; O35240 cytoskeleton; extracellular vesicular exosome; integral to plasma membrane; melanosome; membrane raft; protein homooligomerization IPR001107; IPR018080; IPR001972; Erythrocyte band 7 integral membrane protein (Protein 7.2b) (Stomatin) Stom Epb7.2 Epb72 Mus musculus (Mouse) TR33321_c3_g2_i2 P27105 STOM_HUMAN 5.00E-14 GO:0005737; GO:0005856; GO:0070062; GO:0005887; GO:0042470; GO:0045121; GO:0051260 cytoplasm; cytoskeleton; extracellular vesicular exosome; integral to plasma membrane; melanosome; membrane raft; protein homooligomerization IPR001107; IPR018080; IPR001972; Erythrocyte band 7 integral membrane protein (Protein 7.2b) (Stomatin) STOM BND7 EPB72 Homo sapiens (Human) TR33321_c5_g2_i2 Q9ULJ7 ANR50_HUMAN 7.00E-15 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) TR33322_c0_g1_i1 Q8NHY2 RFWD2_HUMAN 1.00E-85 GO:0006977; GO:0005813; GO:0005829; GO:0005925; GO:0016874; GO:0016607; GO:0005654; GO:0016567; GO:0008270 Q7L5N1; P31947 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; centrosome; cytosol; focal adhesion; ligase activity; nuclear speck; nucleoplasm; protein ubiquitination; zinc ion binding" IPR015943; IPR001680; IPR019775; IPR017986; IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RFWD2 (EC 6.3.2.-) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) RFWD2 COP1 RNF200 Homo sapiens (Human) TR33322_c0_g2_i1 P93471 COP1_PEA 1.00E-45 GO:0005737; GO:0016874; GO:0005634; GO:0016567; GO:0009585; GO:0008270 "cytoplasm; ligase activity; nucleus; protein ubiquitination; red, far-red light phototransduction; zinc ion binding" IPR015943; IPR001680; IPR019775; IPR017986; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase COP1 (EC 6.3.2.-) (Constitutive photomorphogenesis protein 1) COP1 Pisum sativum (Garden pea) TR33322_c0_g3_i1 Q8YRI1 YY46_NOSS1 1.00E-11 GO:0006355 "regulation of transcription, DNA-dependent" IPR001646; IPR020472; IPR007111; IPR027417; IPR011047; IPR027728; IPR015943; IPR001680; IPR019775; IPR017986; Uncharacterized WD repeat-containing protein alr3466 alr3466 Nostoc sp. (strain PCC 7120 / UTEX 2576) TR33322_c1_g2_i1 Q8NHY2 RFWD2_HUMAN 7.00E-40 GO:0006977; GO:0005813; GO:0005829; GO:0005925; GO:0016874; GO:0016607; GO:0005654; GO:0016567; GO:0008270 Q7L5N1; P31947 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; centrosome; cytosol; focal adhesion; ligase activity; nuclear speck; nucleoplasm; protein ubiquitination; zinc ion binding" IPR015943; IPR001680; IPR019775; IPR017986; IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RFWD2 (EC 6.3.2.-) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) RFWD2 COP1 RNF200 Homo sapiens (Human) TR33322_c2_g1_i1 Q94BM7 SPA4_ARATH 4.00E-08 GO:0005524; GO:0080008; GO:0005634; GO:0004672; GO:0009585 Itself; O50055; P43254; Q9SYX2; Q9LJR3 "ATP binding; Cul4-RING ubiquitin ligase complex; nucleus; protein kinase activity; red, far-red light phototransduction" IPR020472; IPR011009; IPR000719; IPR015943; IPR001680; IPR019775; IPR017986; Protein SPA1-RELATED 4 SPA4 At1g53090 F8L10.5 Arabidopsis thaliana (Mouse-ear cress) TR33323_c2_g1_i1 Q8BVE8 NSD2_MOUSE 0 GO:0003677; GO:0003289; GO:0003290; GO:0060348; GO:0003682; GO:0005694; GO:0018024; GO:0003149; GO:0000122; GO:0005634; GO:0006351; GO:0008270 "DNA binding; atrial septum primum morphogenesis; atrial septum secundum morphogenesis; bone development; chromatin binding; chromosome; histone-lysine N-methyltransferase activity; membranous septum morphogenesis; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; zinc ion binding" IPR006560; IPR009071; IPR003616; IPR000313; IPR001214; IPR019786; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.43) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (NSD2) (Wolf-Hirschhorn syndrome candidate 1 protein homolog) (WHSC1) Whsc1 Kiaa1090 Nsd2 Mus musculus (Mouse) TR33323_c2_g1_i2 O96028 NSD2_HUMAN 0 GO:0003677; GO:0009653; GO:0003289; GO:0003290; GO:0060348; GO:0003682; GO:0005694; GO:0005737; GO:0018024; GO:0003149; GO:0000122; GO:0031965; GO:0005730; GO:0006351; GO:0008270 P10275 "DNA binding; anatomical structure morphogenesis; atrial septum primum morphogenesis; atrial septum secundum morphogenesis; bone development; chromatin binding; chromosome; cytoplasm; histone-lysine N-methyltransferase activity; membranous septum morphogenesis; negative regulation of transcription from RNA polymerase II promoter; nuclear membrane; nucleolus; transcription, DNA-dependent; zinc ion binding" IPR006560; IPR009071; IPR003616; IPR000313; IPR001214; IPR019786; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.43) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (NSD2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) (WHSC1) WHSC1 KIAA1090 MMSET NSD2 TRX5 Homo sapiens (Human) TR33326_c1_g1_i2 A1L0Y2 NEUL4_XENTR 2.00E-17 GO:0005814 centriole IPR008985; IPR006573; Neuralized-like protein 4 neurl4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33326_c1_g1_i4 Q5NCX5 NEUL4_MOUSE 2.00E-12 GO:0005814 centriole IPR008985; IPR006573; Neuralized-like protein 4 Neurl4 Kiaa1787 Mus musculus (Mouse) TR33327_c1_g1_i1 D3ZHV2 MACF1_RAT 6.00E-54 GO:0016887; GO:0005794; GO:0043001; GO:0016055; GO:0005509; GO:0007050; GO:0005874; GO:0030177; GO:0010632; GO:0051893; GO:0032886; GO:0032587; GO:0042060 ATPase activity; Golgi apparatus; Golgi to plasma membrane protein transport; Wnt receptor signaling pathway; calcium ion binding; cell cycle arrest; microtubule; positive regulation of Wnt receptor signaling pathway; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of microtubule-based process; ruffle membrane; wound healing IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; IPR003108; IPR001452; IPR018159; IPR002017; Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7) Macf1 Acf7 Aclp7 Macf Rattus norvegicus (Rat) TR33327_c1_g2_i1 Q5SSG4 GA2L2_MOUSE 3.00E-13 GO:0051015; GO:0007050; GO:0005737; GO:0008093; GO:0005874; GO:0008017; GO:0001578; GO:0007026; GO:0001725 actin filament binding; cell cycle arrest; cytoplasm; cytoskeletal adaptor activity; microtubule; microtubule binding; microtubule bundle formation; negative regulation of microtubule depolymerization; stress fiber IPR001715; IPR003108; GAS2-like protein 2 (Growth arrest-specific protein 2-like 2) Gas2l2 Mus musculus (Mouse) TR33328_c0_g1_i1 Q16TM5 BND7A_AEDAE 1.00E-84 GO:0016021 integral to membrane IPR001107; IPR018080; IPR001972; Band 7 protein AAEL010189 AAEL010189 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR33328_c0_g1_i2 Q21190 UNC1_CAEEL 1.00E-76 GO:0030424; GO:0005911; GO:0016021; GO:0042493 axon; cell-cell junction; integral to membrane; response to drug IPR001107; IPR018080; IPR001972; Protein unc-1 (Uncoordinated protein 1) unc-1 K03E6.5 Caenorhabditis elegans TR33330_c1_g4_i1 Q9UBG0 MRC2_HUMAN 3.00E-14 GO:0030246; GO:0006897; GO:0016021 carbohydrate binding; endocytosis; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; C-type mannose receptor 2 (C-type lectin domain family 13 member E) (Endocytic receptor 180) (Macrophage mannose receptor 2) (Urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (Urokinase receptor-associated protein) (CD antigen CD280) MRC2 CLEC13E ENDO180 KIAA0709 UPARAP Homo sapiens (Human) TR33330_c1_g4_i2 P02706 ASGR1_RAT 3.00E-13 GO:0004873; GO:0030246; GO:0016021; GO:0046872 asialoglycoprotein receptor activity; carbohydrate binding; integral to membrane; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; IPR005640; Asialoglycoprotein receptor 1 (ASGP-R 1) (ASGPR 1) (Hepatic lectin 1) (HL-1) (rHL-1) Asgr1 Asgr-1 Rattus norvegicus (Rat) TR33330_c1_g4_i5 P86854 PLCL_MYTGA 7.00E-18 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR33330_c1_g4_i6 Q56EB1 BJCA_BOTJA 8.00E-06 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Snaclec bothrojaracin subunit alpha (BJC subunit alpha) Bothropoides jararaca (Jararaca) (Bothrops jararaca) TR33330_c1_g4_i8 A6QP79 COL12_BOVIN 2.00E-11 GO:0030246; GO:0005581; GO:0006955; GO:0016021; GO:0030169; GO:0046872; GO:0006910; GO:0008329 "carbohydrate binding; collagen; immune response; integral to membrane; low-density lipoprotein particle binding; metal ion binding; phagocytosis, recognition; signaling pattern recognition receptor activity" IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-12 (Collectin placenta protein 1) (CL-P1) COLEC12 CLP1 Bos taurus (Bovine) TR33332_c2_g1_i10 O43825 B3GT2_HUMAN 1.00E-52 GO:0000139; GO:0008499; GO:0016021; GO:0009312; GO:0006486 "Golgi membrane; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; integral to membrane; oligosaccharide biosynthetic process; protein glycosylation" IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 2 (Beta-1,3-GalTase 2) (Beta3Gal-T2) (Beta3GalT2) (EC 2.4.1.-) (UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2)" B3GALT2 Homo sapiens (Human) TR33332_c2_g1_i14 Q9MYM7 B3GT1_PONPY 4.00E-55 GO:0000139; GO:0008378; GO:0016021; GO:0006486 Golgi membrane; galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) TR33332_c2_g1_i2 Q9MYM7 B3GT1_PONPY 4.00E-55 GO:0000139; GO:0008378; GO:0016021; GO:0006486 Golgi membrane; galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) TR33333_c1_g1_i2 O00170 AIP_HUMAN 8.00E-98 GO:0036004; GO:0005829; GO:0016020; GO:0051344; GO:0005634; GO:0022417; GO:0006626; GO:0010738; GO:0004871; GO:0003713; GO:0008134; GO:0051082; GO:0006805 Q92985; O00408 GAF domain binding; cytosol; membrane; negative regulation of cyclic-nucleotide phosphodiesterase activity; nucleus; protein maturation by protein folding; protein targeting to mitochondrion; regulation of protein kinase A signaling cascade; signal transducer activity; transcription coactivator activity; transcription factor binding; unfolded protein binding; xenobiotic metabolic process IPR001179; IPR013026; IPR011990; IPR019734; AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9) AIP XAP2 Homo sapiens (Human) TR33334_c6_g2_i1 O44997 DAPK_CAEEL 1.00E-147 GO:0005524; GO:0045087; GO:0046872; GO:0007275; GO:0004674; GO:0007165 ATP binding; innate immune response; metal ion binding; multicellular organismal development; protein serine/threonine kinase activity; signal transduction IPR002110; IPR020683; IPR011029; IPR000488; IPR011009; IPR020675; IPR027417; IPR000719; IPR017441; IPR002290; IPR008271; Death-associated protein kinase dapk-1 (EC 2.7.11.1) dapk-1 mor-3 tag-119 K12C11.4 Caenorhabditis elegans TR33334_c6_g2_i3 Q80YE7 DAPK1_MOUSE 1.00E-172 GO:0005524; GO:0015629; GO:0005516; GO:0004683; GO:0071346; GO:0005829; GO:0008625; GO:0007243; GO:0043066; GO:1902042; GO:0017148; GO:0046777; GO:0004672; GO:2000310 Q01097 ATP binding; actin cytoskeleton; calmodulin binding; calmodulin-dependent protein kinase activity; cellular response to interferon-gamma; cytosol; extrinsic apoptotic signaling pathway via death domain receptors; intracellular protein kinase cascade; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of translation; protein autophosphorylation; protein kinase activity; regulation of N-methyl-D-aspartate selective glutamate receptor activity IPR002110; IPR020683; IPR011029; IPR000488; IPR011009; IPR020675; IPR027417; IPR000719; IPR017441; IPR002290; IPR008271; Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) Dapk1 Mus musculus (Mouse) TR33334_c6_g3_i1 Q54SJ5 MYLKC_DICDI 3.00E-29 GO:0005524; GO:0004687; GO:0004674 ATP binding; myosin light chain kinase activity; protein serine/threonine kinase activity IPR020636; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Probable myosin light chain kinase DDB_G0282429 (EC 2.7.11.18) DDB_G0282429 Dictyostelium discoideum (Slime mold) TR33336_c1_g1_i1 P27042 LYG_CHICK 3.00E-38 GO:0016998; GO:0019835; GO:0042742; GO:0005576; GO:0003796; GO:0009253 cell wall macromolecule catabolic process; cytolysis; defense response to bacterium; extracellular region; lysozyme activity; peptidoglycan catabolic process IPR002152; IPR023346; IPR008258; "Lysozyme g (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase) (Goose-type lysozyme)" Gallus gallus (Chicken) TR33336_c1_g1_i2 B3A0P5 GEPRP_LOTGI 2.00E-59 GO:0016998; GO:0005576; GO:0003796; GO:0009253 cell wall macromolecule catabolic process; extracellular region; lysozyme activity; peptidoglycan catabolic process IPR002152; IPR023346; IPR008258; "Glycine, glutamate and proline-rich protein" Lottia gigantea (Giant owl limpet) TR33336_c1_g1_i5 B3A0P5 GEPRP_LOTGI 2.00E-57 GO:0016998; GO:0005576; GO:0003796; GO:0009253 cell wall macromolecule catabolic process; extracellular region; lysozyme activity; peptidoglycan catabolic process IPR002152; IPR023346; IPR008258; "Glycine, glutamate and proline-rich protein" Lottia gigantea (Giant owl limpet) TR33336_c1_g1_i6 Q86SG7 LYG2_HUMAN 3.00E-19 GO:0016998; GO:0005576; GO:0003796; GO:0009253 cell wall macromolecule catabolic process; extracellular region; lysozyme activity; peptidoglycan catabolic process IPR002152; IPR023346; IPR008258; Lysozyme g-like protein 2 (EC 3.2.1.-) LYG2 LYGH Homo sapiens (Human) TR33337_c0_g1_i1 P49815 TSC2_HUMAN 2.00E-138 GO:0038095; GO:0005096; GO:0005794; GO:0033596; GO:0006953; GO:0005901; GO:0007050; GO:0030030; GO:0030425; GO:0006897; GO:0007173; GO:0008543; GO:0030426; GO:0007507; GO:0045087; GO:0008286; GO:0048009; GO:0016020; GO:0043407; GO:0032007; GO:0030178; GO:0008285; GO:0045792; GO:0050680; GO:0014067; GO:0051898; GO:0006469; GO:0001843; GO:0043025; GO:0048011; GO:0005634; GO:0048471; GO:0019902; GO:0014065; GO:0048015; GO:0050918; GO:0051291; GO:0051260; GO:0006606; GO:0043491; GO:0030100; GO:0046626; GO:0051056; GO:0001666 P62136; Q96EB6; Q92574; P31946; P63104 Fc-epsilon receptor signaling pathway; GTPase activator activity; Golgi apparatus; TSC1-TSC2 complex; acute-phase response; caveola; cell cycle arrest; cell projection organization; dendrite; endocytosis; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; growth cone; heart development; innate immune response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; membrane; negative regulation of MAP kinase activity; negative regulation of TOR signaling cascade; negative regulation of Wnt receptor signaling pathway; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of epithelial cell proliferation; negative regulation of phosphatidylinositol 3-kinase cascade; negative regulation of protein kinase B signaling cascade; negative regulation of protein kinase activity; neural tube closure; neuronal cell body; neurotrophin TRK receptor signaling pathway; nucleus; perinuclear region of cytoplasm; phosphatase binding; phosphatidylinositol 3-kinase cascade; phosphatidylinositol-mediated signaling; positive chemotaxis; protein heterooligomerization; protein homooligomerization; protein import into nucleus; protein kinase B signaling cascade; regulation of endocytosis; regulation of insulin receptor signaling pathway; regulation of small GTPase mediated signal transduction; response to hypoxia IPR011989; IPR016024; IPR000331; IPR003913; IPR018515; IPR027107; IPR024584; Tuberin (Tuberous sclerosis 2 protein) TSC2 TSC4 Homo sapiens (Human) TR33337_c1_g5_i1 Q9UUG9 TSC2_SCHPO 1.00E-40 GO:0005096; GO:0031929; GO:0033596; GO:0034613; GO:0006995; GO:0032091; GO:0005634; GO:0043547; GO:0010963; GO:0033157; GO:0051056 GTPase activator activity; TOR signaling cascade; TSC1-TSC2 complex; cellular protein localization; cellular response to nitrogen starvation; negative regulation of protein binding; nucleus; positive regulation of GTPase activity; regulation of L-arginine import; regulation of intracellular protein transport; regulation of small GTPase mediated signal transduction IPR000331; IPR018515; IPR027107; IPR024584; Tuberous sclerosis 2 protein homolog tsc2 SPAC630.13c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR33337_c1_g5_i3 P49815 TSC2_HUMAN 2.00E-77 GO:0038095; GO:0005096; GO:0005794; GO:0033596; GO:0006953; GO:0005901; GO:0007050; GO:0030030; GO:0030425; GO:0006897; GO:0007173; GO:0008543; GO:0030426; GO:0007507; GO:0045087; GO:0008286; GO:0048009; GO:0016020; GO:0043407; GO:0032007; GO:0030178; GO:0008285; GO:0045792; GO:0050680; GO:0014067; GO:0051898; GO:0006469; GO:0001843; GO:0043025; GO:0048011; GO:0005634; GO:0048471; GO:0019902; GO:0014065; GO:0048015; GO:0050918; GO:0051291; GO:0051260; GO:0006606; GO:0043491; GO:0030100; GO:0046626; GO:0051056; GO:0001666 P62136; Q96EB6; Q92574; P31946; P63104 Fc-epsilon receptor signaling pathway; GTPase activator activity; Golgi apparatus; TSC1-TSC2 complex; acute-phase response; caveola; cell cycle arrest; cell projection organization; dendrite; endocytosis; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; growth cone; heart development; innate immune response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; membrane; negative regulation of MAP kinase activity; negative regulation of TOR signaling cascade; negative regulation of Wnt receptor signaling pathway; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of epithelial cell proliferation; negative regulation of phosphatidylinositol 3-kinase cascade; negative regulation of protein kinase B signaling cascade; negative regulation of protein kinase activity; neural tube closure; neuronal cell body; neurotrophin TRK receptor signaling pathway; nucleus; perinuclear region of cytoplasm; phosphatase binding; phosphatidylinositol 3-kinase cascade; phosphatidylinositol-mediated signaling; positive chemotaxis; protein heterooligomerization; protein homooligomerization; protein import into nucleus; protein kinase B signaling cascade; regulation of endocytosis; regulation of insulin receptor signaling pathway; regulation of small GTPase mediated signal transduction; response to hypoxia IPR011989; IPR016024; IPR000331; IPR003913; IPR018515; IPR027107; IPR024584; Tuberin (Tuberous sclerosis 2 protein) TSC2 TSC4 Homo sapiens (Human) TR33340_c0_g1_i1 O94049 ACS1_CANAX 7.00E-60 GO:0016208; GO:0005524; GO:0003987; GO:0019427 AMP binding; ATP binding; acetate-CoA ligase activity; acetyl-CoA biosynthetic process from acetate IPR011904; IPR025110; IPR020845; IPR000873; Acetyl-coenzyme A synthetase 1 (EC 6.2.1.1) (Acetate--CoA ligase 1) (Acyl-activating enzyme 1) ACS1 Ca38F10.03 Candida albicans (Yeast) TR33340_c0_g1_i2 Q5REV5 ACSM3_PONAB 0 GO:0005524; GO:0047760; GO:0006633; GO:0015645; GO:0046872; GO:0005759 ATP binding; butyrate-CoA ligase activity; fatty acid biosynthetic process; fatty acid ligase activity; metal ion binding; mitochondrial matrix IPR025110; IPR020845; IPR000873; "Acyl-coenzyme A synthetase ACSM3, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 3) (Butyrate--CoA ligase 3) (Butyryl-coenzyme A synthetase 3) (Middle-chain acyl-CoA synthetase 3) (Protein SA homolog)" ACSM3 SAH Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33341_c0_g1_i3 Q5UQ35 YR811_MIMIV 2.00E-13 GO:0008270 zinc ion binding IPR002035; IPR002867; IPR001841; Putative ariadne-like RING finger protein R811 MIMI_R811 Acanthamoeba polyphaga mimivirus (APMV) TR33342_c0_g1_i1 Q8JZP3 KLHL2_MOUSE 2.00E-22 GO:0031463; GO:0003779; GO:0005737; GO:0005829; GO:0030027; GO:0042803; GO:0016567; GO:0001726; GO:0001725 Cul3-RING ubiquitin ligase complex; actin binding; cytoplasm; cytosol; lamellipodium; protein homodimerization activity; protein ubiquitination; ruffle; stress fiber IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 2 Klhl2 Mus musculus (Mouse) TR33342_c0_g1_i2 Q0D2K2 KLH30_HUMAN 2.00E-23 IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 30 KLHL30 Homo sapiens (Human) TR33343_c1_g1_i1 Q8WXF0 SRS12_HUMAN 6.00E-11 GO:0003723; GO:0050733; GO:0000244; GO:0016482; GO:0000395; GO:0048025; GO:0005654; GO:0000166; GO:0000381; GO:0051082 "RNA binding; RS domain binding; assembly of spliceosomal tri-snRNP; cytoplasmic transport; mRNA 5'-splice site recognition; negative regulation of mRNA splicing, via spliceosome; nucleoplasm; nucleotide binding; regulation of alternative mRNA splicing, via spliceosome; unfolded protein binding" IPR012677; IPR000504; "Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)" SRSF12 SFRS13B SFRS19 SRRP35 Homo sapiens (Human) TR33343_c1_g1_i3 Q3T106 SRSF7_BOVIN 2.00E-12 GO:0003723; GO:0008380; GO:0006397; GO:0048025; GO:0000166; GO:0005634; GO:0008270 "RNA binding; RNA splicing; mRNA processing; negative regulation of mRNA splicing, via spliceosome; nucleotide binding; nucleus; zinc ion binding" IPR012677; IPR000504; IPR001878; "Serine/arginine-rich splicing factor 7 (Splicing factor, arginine/serine-rich 7)" SRSF7 SFRS7 Bos taurus (Bovine) TR33343_c1_g1_i5 Q8WXF0 SRS12_HUMAN 3.00E-42 GO:0003723; GO:0050733; GO:0000244; GO:0016482; GO:0000395; GO:0048025; GO:0005654; GO:0000166; GO:0000381; GO:0051082 "RNA binding; RS domain binding; assembly of spliceosomal tri-snRNP; cytoplasmic transport; mRNA 5'-splice site recognition; negative regulation of mRNA splicing, via spliceosome; nucleoplasm; nucleotide binding; regulation of alternative mRNA splicing, via spliceosome; unfolded protein binding" IPR012677; IPR000504; "Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)" SRSF12 SFRS13B SFRS19 SRRP35 Homo sapiens (Human) TR33343_c2_g1_i3 Q9UBW7 ZMYM2_HUMAN 2.00E-07 GO:0016605; GO:0005829; GO:0006355; GO:0006351; GO:0008270 "PML body; cytosol; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR021893; IPR011017; IPR010507; Zinc finger MYM-type protein 2 (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein) (Zinc finger protein 198) ZMYM2 FIM RAMP ZNF198 Homo sapiens (Human) TR33343_c2_g1_i5 Q8N8K9 K1958_HUMAN 3.00E-09 IPR021893; Uncharacterized protein KIAA1958 KIAA1958 Homo sapiens (Human) TR33344_c0_g1_i1 P00727 AMPL_BOVIN 0 GO:0004177; GO:0030145; GO:0008235; GO:0005739; GO:0005634; GO:0008233; GO:0006508 aminopeptidase activity; manganese ion binding; metalloexopeptidase activity; mitochondrion; nucleus; peptidase activity; proteolysis IPR011356; IPR000819; IPR023042; IPR008283; Cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) LAP3 Bos taurus (Bovine) TR33345_c1_g1_i3 O95714 HERC2_HUMAN 2.00E-09 GO:0006281; GO:0032183; GO:0005814; GO:0005737; GO:0005085; GO:0020037; GO:0006886; GO:0005634; GO:0042787; GO:0004842; GO:0008270 DNA repair; SUMO binding; centriole; cytoplasm; guanyl-nucleotide exchange factor activity; heme binding; intracellular protein transport; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR004939; IPR006624; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) HERC2 Homo sapiens (Human) TR33346_c0_g1_i1 Q22361 YFR3_CAEEL 2.00E-16 GO:0016021; GO:0035556 integral to membrane; intracellular signal transduction IPR003377; Uncharacterized protein T09E8.3 T09E8.3 Caenorhabditis elegans TR33346_c0_g1_i2 P53173 ERV14_YEAST 8.00E-22 GO:0030134; GO:0006888; GO:0000139; GO:0030437; GO:0007120; GO:0005789; GO:0016021; GO:0035556 ER to Golgi transport vesicle; ER to Golgi vesicle-mediated transport; Golgi membrane; ascospore formation; axial cellular bud site selection; endoplasmic reticulum membrane; integral to membrane; intracellular signal transduction IPR003377; ER-derived vesicles protein ERV14 ERV14 YGL054C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33346_c0_g1_i3 Q6P3N5 CNIH4_XENTR 4.00E-52 GO:0016021; GO:0035556 integral to membrane; intracellular signal transduction IPR003377; Protein cornichon homolog 4 (CNIH-4) (Cornichon family AMPA receptor auxiliary protein 4) cnih4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33348_c0_g1_i1 Q5T2R2 DPS1_HUMAN 4.00E-135 GO:0008299; GO:0046872; GO:0005759; GO:0046982; GO:0051290; GO:0000010; GO:0050347; GO:0006744 isoprenoid biosynthetic process; metal ion binding; mitochondrial matrix; protein heterodimerization activity; protein heterotetramerization; trans-hexaprenyltranstransferase activity; trans-octaprenyltranstransferase activity; ubiquinone biosynthetic process IPR000092; IPR017446; IPR008949; Cofactor biosynthesis; ubiquinone biosynthesis. Decaprenyl-diphosphate synthase subunit 1 (EC 2.5.1.91) (All-trans-decaprenyl-diphosphate synthase subunit 1) (Decaprenyl pyrophosphate synthase subunit 1) (Trans-prenyltransferase 1) (TPT 1) PDSS1 DPS1 TPRT Homo sapiens (Human) TR33348_c0_g1_i2 Q39108 GGR_ARATH 1.00E-06 GO:0009507; GO:0008299; GO:0046872 chloroplast; isoprenoid biosynthetic process; metal ion binding IPR000092; IPR017446; IPR008949; "Heterodimeric geranylgeranyl pyrophosphate synthase small subunit, chloroplastic" GGR At4g38460 F20M13.20 Arabidopsis thaliana (Mouse-ear cress) TR33348_c0_g1_i3 Q5T2R2 DPS1_HUMAN 4.00E-50 GO:0008299; GO:0046872; GO:0005759; GO:0046982; GO:0051290; GO:0000010; GO:0050347; GO:0006744 isoprenoid biosynthetic process; metal ion binding; mitochondrial matrix; protein heterodimerization activity; protein heterotetramerization; trans-hexaprenyltranstransferase activity; trans-octaprenyltranstransferase activity; ubiquinone biosynthetic process IPR000092; IPR017446; IPR008949; Cofactor biosynthesis; ubiquinone biosynthesis. Decaprenyl-diphosphate synthase subunit 1 (EC 2.5.1.91) (All-trans-decaprenyl-diphosphate synthase subunit 1) (Decaprenyl pyrophosphate synthase subunit 1) (Trans-prenyltransferase 1) (TPT 1) PDSS1 DPS1 TPRT Homo sapiens (Human) TR33349_c0_g1_i3 Q08DP2 L12R1_BOVIN 8.00E-42 IPR018780; Loss of heterozygosity 12 chromosomal region 1 protein homolog LOH12CR1 Bos taurus (Bovine) TR33350_c0_g1_i3 Q99JH1 RP25L_MOUSE 6.00E-33 GO:0003676; GO:0005634 nucleic acid binding; nucleus IPR002775; Ribonuclease P protein subunit p25-like protein (RNase P protein subunit-like p25) (Rpp25-like protein) Rpp25l Mus musculus (Mouse) TR33351_c6_g2_i1 Q13884 SNTB1_HUMAN 2.00E-150 GO:0030054; GO:0005737; GO:0005856; GO:0016010; GO:0006936; GO:0005543; GO:0042383; GO:0045202 O95477; P11532 cell junction; cytoplasm; cytoskeleton; dystrophin-associated glycoprotein complex; muscle contraction; phospholipid binding; sarcolemma; synapse IPR001478; IPR011993; IPR001849; IPR015482; Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43) SNTB1 SNT2B1 Homo sapiens (Human) TR33353_c0_g1_i1 P20073 ANXA7_HUMAN 2.00E-74 GO:0005509; GO:0005544; GO:0008283; GO:0006874; GO:0009992; GO:0005829; GO:0005789; GO:0007599; GO:0005635; GO:0005634; GO:0005886; GO:0008360; GO:0009651; GO:0035176; GO:0031982 calcium ion binding; calcium-dependent phospholipid binding; cell proliferation; cellular calcium ion homeostasis; cellular water homeostasis; cytosol; endoplasmic reticulum membrane; hemostasis; nuclear envelope; nucleus; plasma membrane; regulation of cell shape; response to salt stress; social behavior; vesicle IPR001464; IPR018502; IPR018252; IPR013286; Annexin A7 (Annexin VII) (Annexin-7) (Synexin) ANXA7 ANX7 SNX OK/SW-cl.95 Homo sapiens (Human) TR33353_c0_g1_i2 P20073 ANXA7_HUMAN 2.00E-74 GO:0005509; GO:0005544; GO:0008283; GO:0006874; GO:0009992; GO:0005829; GO:0005789; GO:0007599; GO:0005635; GO:0005634; GO:0005886; GO:0008360; GO:0009651; GO:0035176; GO:0031982 calcium ion binding; calcium-dependent phospholipid binding; cell proliferation; cellular calcium ion homeostasis; cellular water homeostasis; cytosol; endoplasmic reticulum membrane; hemostasis; nuclear envelope; nucleus; plasma membrane; regulation of cell shape; response to salt stress; social behavior; vesicle IPR001464; IPR018502; IPR018252; IPR013286; Annexin A7 (Annexin VII) (Annexin-7) (Synexin) ANXA7 ANX7 SNX OK/SW-cl.95 Homo sapiens (Human) TR33356_c8_g1_i4 A1L243 MESD_DANRE 7.00E-56 GO:0016055; GO:0005783 Wnt receptor signaling pathway; endoplasmic reticulum IPR019330; LDLR chaperone MESD (Mesoderm development candidate 2) (Mesoderm development protein) mesdc2 zgc:158636 Danio rerio (Zebrafish) (Brachydanio rerio) TR33357_c0_g2_i1 Q99J36 THUM1_MOUSE 7.00E-49 GO:0003723 RNA binding IPR004114; THUMP domain-containing protein 1 Thumpd1 Mus musculus (Mouse) TR33357_c0_g2_i2 Q24K03 THUM1_BOVIN 1.00E-50 GO:0003723 RNA binding IPR004114; THUMP domain-containing protein 1 THUMPD1 Bos taurus (Bovine) TR33360_c0_g1_i1 P20918 PLMN_MOUSE 2.00E-21 GO:0007596; GO:0022617; GO:0005615; GO:0031232; GO:0019897; GO:0042730; GO:0043231; GO:0060716; GO:0071674; GO:0046716; GO:0045445; GO:0016525; GO:0010812; GO:0051918; GO:0051919; GO:0051603; GO:0004252; GO:0042246; GO:0048771; GO:0060707 blood coagulation; extracellular matrix disassembly; extracellular space; extrinsic to external side of plasma membrane; extrinsic to plasma membrane; fibrinolysis; intracellular membrane-bounded organelle; labyrinthine layer blood vessel development; mononuclear cell migration; muscle cell cellular homeostasis; myoblast differentiation; negative regulation of angiogenesis; negative regulation of cell-substrate adhesion; negative regulation of fibrinolysis; positive regulation of fibrinolysis; proteolysis involved in cellular protein catabolic process; serine-type endopeptidase activity; tissue regeneration; tissue remodeling; trophoblast giant cell differentiation IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]" Plg Mus musculus (Mouse) TR33360_c0_g2_i1 P57999 ZAN_RABIT 6.00E-36 GO:0007155; GO:0016021; GO:0005886 cell adhesion; integral to membrane; plasma membrane IPR008985; IPR000742; IPR013032; IPR000998; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; Zonadhesin (Fragment) ZAN Oryctolagus cuniculus (Rabbit) TR33360_c0_g2_i4 P57999 ZAN_RABIT 2.00E-55 GO:0007155; GO:0016021; GO:0005886 cell adhesion; integral to membrane; plasma membrane IPR008985; IPR000742; IPR013032; IPR000998; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; Zonadhesin (Fragment) ZAN Oryctolagus cuniculus (Rabbit) TR33360_c0_g3_i2 P14417 APOA_MACMU 3.00E-49 GO:0006869; GO:0006508; GO:0004252 lipid transport; proteolysis; serine-type endopeptidase activity IPR000001; IPR013806; IPR018056; IPR001254; IPR001314; IPR009003; Apolipoprotein(a) (Apo(a)) (Lp(a)) (EC 3.4.21.-) (Fragment) LPA Macaca mulatta (Rhesus macaque) TR33360_c0_g3_i3 Q7M323 PLMN_CAPHI 4.00E-17 GO:0007596; GO:0005576; GO:0042730; GO:0006508; GO:0008236; GO:0048771 blood coagulation; extracellular region; fibrinolysis; proteolysis; serine-type peptidase activity; tissue remodeling IPR000001; IPR013806; IPR018056; Plasminogen (EC 3.4.21.7) (Fragment) PLG Capra hircus (Goat) TR33362_c1_g2_i1 Q5XH95 SCMC2_XENTR 1.00E-168 GO:0005509; GO:0016021; GO:0005743; GO:0055085 calcium ion binding; integral to membrane; mitochondrial inner membrane; transmembrane transport IPR011992; IPR002048; IPR002167; IPR002067; IPR018108; IPR023395; Calcium-binding mitochondrial carrier protein SCaMC-2 (Small calcium-binding mitochondrial carrier protein 2) (Solute carrier family 25 member 25) slc25a25 scamc2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33363_c0_g1_i1 Q8C8R3 ANK2_MOUSE 3.00E-26 GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005887; GO:0014704; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086015; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307 "M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; integral to plasma membrane; intercalated disc; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of SA node cell action potential; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Brain ankyrin) Ank2 Mus musculus (Mouse) TR33363_c0_g1_i2 Q8Q0U0 Y045_METMA 3.00E-26 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR33363_c0_g1_i3 Q653P0 KOR1_ORYSJ 2.00E-12 GO:0016021; GO:0005249 integral to membrane; voltage-gated potassium channel activity IPR002110; IPR020683; IPR018490; IPR000595; IPR005821; IPR021789; IPR003938; IPR014710; Potassium channel KOR1 (K(+) outward-rectifying channel 1) Os06g0250600 LOC_Os06g14030 OSJNBa0091G06.35 P0431E05.11 Oryza sativa subsp. japonica (Rice) TR33363_c0_g1_i4 Q8N6D5 ANR29_HUMAN 9.00E-19 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 29 ANKRD29 Homo sapiens (Human) TR33363_c0_g1_i6 P16157 ANK1_HUMAN 9.00E-27 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR33364_c0_g1_i2 Q2G512 ACSA_NOVAD 0 GO:0016208; GO:0005524; GO:0003987; GO:0019427; GO:0046872 AMP binding; ATP binding; acetate-CoA ligase activity; acetyl-CoA biosynthetic process from acetate; metal ion binding IPR011904; IPR025110; IPR020845; IPR000873; Acetyl-coenzyme A synthetase (AcCoA synthetase) (Acs) (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme) acsA Saro_2625 Novosphingobium aromaticivorans (strain DSM 12444) TR33364_c0_g1_i4 B1ZB59 ACSA_METPB 0 GO:0016208; GO:0005524; GO:0003987; GO:0019427; GO:0046872 AMP binding; ATP binding; acetate-CoA ligase activity; acetyl-CoA biosynthetic process from acetate; metal ion binding IPR011904; IPR025110; IPR020845; IPR000873; Acetyl-coenzyme A synthetase (AcCoA synthetase) (Acs) (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme) acsA Mpop_2494 Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001) TR33364_c0_g1_i5 Q9NUB1 ACS2L_HUMAN 0 GO:0016208; GO:0005524; GO:0019413; GO:0003987; GO:0006085; GO:0019427; GO:0006069; GO:0005759; GO:0019542; GO:0006805 AMP binding; ATP binding; acetate biosynthetic process; acetate-CoA ligase activity; acetyl-CoA biosynthetic process; acetyl-CoA biosynthetic process from acetate; ethanol oxidation; mitochondrial matrix; propionate biosynthetic process; xenobiotic metabolic process IPR011904; IPR025110; IPR020845; IPR000873; "Acetyl-coenzyme A synthetase 2-like, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1)" ACSS1 ACAS2L KIAA1846 Homo sapiens (Human) TR33364_c0_g1_i6 Q9NUB1 ACS2L_HUMAN 2.00E-74 GO:0016208; GO:0005524; GO:0019413; GO:0003987; GO:0006085; GO:0019427; GO:0006069; GO:0005759; GO:0019542; GO:0006805 AMP binding; ATP binding; acetate biosynthetic process; acetate-CoA ligase activity; acetyl-CoA biosynthetic process; acetyl-CoA biosynthetic process from acetate; ethanol oxidation; mitochondrial matrix; propionate biosynthetic process; xenobiotic metabolic process IPR011904; IPR025110; IPR020845; IPR000873; "Acetyl-coenzyme A synthetase 2-like, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1)" ACSS1 ACAS2L KIAA1846 Homo sapiens (Human) TR33365_c3_g2_i2 P22105 TENX_HUMAN 2.00E-23 GO:0030036; GO:0007155; GO:0016337; GO:0007160; GO:0030199; GO:0032963; GO:0048251; GO:0043206; GO:0005615; GO:0006631; GO:0008201; GO:0005178; GO:0005622; GO:0005578; GO:0043506; GO:0006641 actin cytoskeleton organization; cell adhesion; cell-cell adhesion; cell-matrix adhesion; collagen fibril organization; collagen metabolic process; elastic fiber assembly; extracellular fibril organization; extracellular space; fatty acid metabolic process; heparin binding; integrin binding; intracellular; proteinaceous extracellular matrix; regulation of JUN kinase activity; triglyceride metabolic process IPR000742; IPR013032; IPR014716; IPR014715; IPR002181; IPR020837; IPR003961; IPR013783; Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) TR33367_c0_g1_i1 Q54MH0 FHKD_DICDI 1.00E-16 GO:0005524; GO:0000077; GO:0004674 ATP binding; DNA damage checkpoint; protein serine/threonine kinase activity IPR020636; IPR000253; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR008984; Probable serine/threonine-protein kinase fhkD (EC 2.7.11.1) (Forkhead-associated kinase protein D) fhkD fhakd DDB_G0285963 Dictyostelium discoideum (Slime mold) TR33367_c0_g1_i2 Q7YR43 DDR1_PANTR 1.00E-07 GO:0005524; GO:0060444; GO:0005518; GO:0043583; GO:0007566; GO:0016021; GO:0007595; GO:0060749; GO:0046872; GO:0008285; GO:0038083; GO:0005886; GO:0038062; GO:0001558; GO:0001952; GO:0010715; GO:0014909; GO:0061302; GO:0044319 "ATP binding; branching involved in mammary gland duct morphogenesis; collagen binding; ear development; embryo implantation; integral to membrane; lactation; mammary gland alveolus development; metal ion binding; negative regulation of cell proliferation; peptidyl-tyrosine autophosphorylation; plasma membrane; protein tyrosine kinase collagen receptor activity; regulation of cell growth; regulation of cell-matrix adhesion; regulation of extracellular matrix disassembly; smooth muscle cell migration; smooth muscle cell-matrix adhesion; wound healing, spreading of cells" IPR000421; IPR008979; IPR011009; IPR000719; IPR001245; IPR008266; IPR020635; IPR002011; Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Discoidin receptor tyrosine kinase) (Tyrosine kinase DDR) (CD antigen CD167a) DDR1 EDDR1 Pan troglodytes (Chimpanzee) TR33367_c0_g2_i1 Q96RU8 TRIB1_HUMAN 1.00E-08 GO:0007254; GO:0005737; GO:0031434; GO:0031665; GO:0043433; GO:0014912; GO:0048662; GO:0005634; GO:0032436; GO:0004860; GO:0043405; GO:0032496; GO:0016772; GO:0031625; GO:0055106 "JNK cascade; cytoplasm; mitogen-activated protein kinase kinase binding; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; nucleus; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein kinase inhibitor activity; regulation of MAP kinase activity; response to lipopolysaccharide; transferase activity, transferring phosphorus-containing groups; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity" IPR011009; IPR000719; IPR024104; IPR024105; Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1) TRIB1 C8FW GIG2 TRB1 Homo sapiens (Human) TR33367_c0_g2_i2 Q3SZW1 TSSK1_BOVIN 5.00E-39 GO:0005524; GO:0001669; GO:0046872; GO:0031514; GO:0007275; GO:0004674; GO:0007286 ATP binding; acrosomal vesicle; metal ion binding; motile cilium; multicellular organismal development; protein serine/threonine kinase activity; spermatid development IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Testis-specific serine/threonine-protein kinase 1 (TSK-1) (TSK1) (TSSK-1) (Testis-specific kinase 1) (EC 2.7.11.1) TSSK1B TSSK1 Bos taurus (Bovine) TR33368_c1_g2_i1 Q499Q5 MKS1_RAT 7.00E-83 GO:0036038; GO:0005813; GO:0042384; GO:0005737; GO:0005932 TCTN-B9D complex; centrosome; cilium assembly; cytoplasm; microtubule basal body IPR010796; Meckel syndrome type 1 protein homolog Mks1 Rattus norvegicus (Rat) TR33371_c1_g2_i1 Q5BIM1 TRI45_BOVIN 9.00E-13 GO:0005737; GO:0005634; GO:0008270 cytoplasm; nucleus; zinc ion binding IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) TR33371_c1_g2_i2 E1BD59 TRI56_BOVIN 4.00E-14 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) TR33371_c1_g2_i3 Q9R1R2 TRIM3_MOUSE 6.00E-08 GO:0005737; GO:0005769; GO:0015031; GO:0008270 cytoplasm; early endosome; protein transport; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) TR33371_c1_g2_i4 Q80VI1 TRI56_MOUSE 5.00E-15 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) TR33371_c1_g2_i5 Q5BIM1 TRI45_BOVIN 9.00E-13 GO:0005737; GO:0005634; GO:0008270 cytoplasm; nucleus; zinc ion binding IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) TR33371_c1_g2_i7 Q2YEM9 TRIM5_PONPY 1.00E-08 GO:0000932; GO:0051607; GO:0045087; GO:0043123; GO:0043410; GO:0051092; GO:0070534; GO:0031664; GO:0008329; GO:0004842; GO:0008270 cytoplasmic mRNA processing body; defense response to virus; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAPK cascade; positive regulation of NF-kappaB transcription factor activity; protein K63-linked ubiquitination; regulation of lipopolysaccharide-mediated signaling pathway; signaling pattern recognition receptor activity; ubiquitin-protein ligase activity; zinc ion binding IPR001870; IPR003879; IPR008985; IPR003877; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 5 (EC 6.3.2.-) (TRIM5alpha) TRIM5 Pongo pygmaeus (Bornean orangutan) TR33371_c1_g2_i8 E1BD59 TRI56_BOVIN 4.00E-14 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) TR33372_c0_g1_i1 Q8CDU4 FXL13_MOUSE 2.00E-10 IPR001810; IPR006553; F-box/LRR-repeat protein 13 (F-box and leucine-rich repeat protein 13) Fbxl13 Mus musculus (Mouse) TR33372_c0_g1_i2 P34284 YKK7_CAEEL 1.00E-19 IPR001810; IPR006553; Uncharacterized F-box/LRR-repeat protein C02F5.7 C02F5.7 Caenorhabditis elegans TR33372_c0_g1_i3 Q5MJ12 FXL16_RAT 3.00E-07 IPR001810; F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16) (Spinal cord injury and regeneration-related protein 1) Fbxl16 Scirr1 Rattus norvegicus (Rat) TR33372_c0_g1_i4 Q8BID8 FXL14_MOUSE 1.00E-16 GO:0005737; GO:0042787; GO:0004842 cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR001810; IPR013101; F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14) Fbxl14 Fbl14 Ppa Mus musculus (Mouse) TR33372_c0_g1_i5 Q96IG2 FXL20_HUMAN 9.00E-17 GO:0005737 cytoplasm IPR001810; IPR006553; F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like) FBXL20 FBL2 Homo sapiens (Human) TR33372_c0_g1_i6 Q5MJ12 FXL16_RAT 3.00E-07 IPR001810; F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16) (Spinal cord injury and regeneration-related protein 1) Fbxl16 Scirr1 Rattus norvegicus (Rat) TR33372_c0_g1_i8 Q8LB33 FB330_ARATH 1.00E-06 GO:0005829 cytosol IPR006553; F-box protein At3g58530 At3g58530 F14P22.120 Arabidopsis thaliana (Mouse-ear cress) TR33373_c3_g1_i2 Q7TT16 IPMK_MOUSE 3.00E-06 GO:0005524; GO:0032958; GO:0000824; GO:0008440; GO:0000823; GO:0001841; GO:0005634 "ATP binding; inositol phosphate biosynthetic process; inositol tetrakisphosphate 3-kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; inositol-1,4,5-trisphosphate 6-kinase activity; neural tube formation; nucleus" IPR005522; "Inositol polyphosphate multikinase (EC 2.7.1.151) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase)" Ipmk Impk Mus musculus (Mouse) TR33374_c0_g1_i1 P86854 PLCL_MYTGA 5.00E-40 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR33374_c0_g1_i3 Q90WJ8 AJL2_ANGJA 5.00E-17 GO:0030246; GO:0050829; GO:0005576; GO:0043152 carbohydrate binding; defense response to Gram-negative bacterium; extracellular region; induction of bacterial agglutination IPR001304; IPR016186; IPR018378; IPR016187; Lactose-binding lectin l-2 (Ajl-2) l-2 Anguilla japonica (Japanese eel) TR33374_c0_g1_i4 Q8N1N0 CLC4F_HUMAN 1.00E-09 GO:0030246; GO:0006897; GO:0016021 carbohydrate binding; endocytosis; integral to membrane IPR001304; IPR016186; IPR016187; C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13) CLEC4F CLECSF13 Homo sapiens (Human) TR33375_c2_g1_i1 P18549 CEFD_STRC2 5.00E-20 GO:0017000; GO:0045439; GO:0030170 antibiotic biosynthetic process; isopenicillin-N epimerase activity; pyridoxal phosphate binding IPR000192; IPR020578; IPR015424; IPR015421; IPR015422; Antibiotic biosynthesis; cephalosporin C biosynthesis. Isopenicillin N epimerase (EC 5.1.1.17) cefD Streptomyces clavuligerus (strain ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602) TR33375_c2_g1_i4 O94431 YHKC_SCHPO 8.00E-31 GO:0005829; GO:0005634; GO:0030170; GO:0008483 cytosol; nucleus; pyridoxal phosphate binding; transaminase activity IPR000192; IPR015424; IPR015421; Uncharacterized aminotransferase C660.12c (EC 2.6.-.-) SPBC660.12c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR33379_c0_g4_i1 Q9BGL2 LRAT_BOVIN 2.00E-07 GO:0005789; GO:0016021; GO:0005771; GO:0048471; GO:0047173; GO:0050896; GO:0042572; GO:0005791; GO:0007601 endoplasmic reticulum membrane; integral to membrane; multivesicular body; perinuclear region of cytoplasm; phosphatidylcholine-retinol O-acyltransferase activity; response to stimulus; retinol metabolic process; rough endoplasmic reticulum; visual perception IPR007053; Cofactor metabolism; retinol metabolism. Lecithin retinol acyltransferase (EC 2.3.1.135) (Phosphatidylcholine--retinol O-acyltransferase) LRAT Bos taurus (Bovine) TR33379_c0_g4_i2 Q9JI60 LRAT_MOUSE 1.00E-07 GO:0006653; GO:0008374; GO:0009790; GO:0005789; GO:0016021; GO:0005771; GO:0048471; GO:0047173; GO:0050896; GO:0001972; GO:0042573; GO:0019841; GO:0042572; GO:0005791; GO:0007601; GO:0006776 "1,2-diacyl-sn-glycero-3-phosphocholine metabolic process; O-acyltransferase activity; embryo development; endoplasmic reticulum membrane; integral to membrane; multivesicular body; perinuclear region of cytoplasm; phosphatidylcholine-retinol O-acyltransferase activity; response to stimulus; retinoic acid binding; retinoic acid metabolic process; retinol binding; retinol metabolic process; rough endoplasmic reticulum; visual perception; vitamin A metabolic process" IPR007053; Cofactor metabolism; retinol metabolism. Lecithin retinol acyltransferase (EC 2.3.1.135) (Phosphatidylcholine--retinol O-acyltransferase) (Phosphatidylcholine-retinol-O-acyltransferase) Lrat Mus musculus (Mouse) TR33379_c0_g4_i3 Q9JI61 LRAT_RAT 3.00E-07 GO:0009790; GO:0005789; GO:0016021; GO:0005771; GO:0048471; GO:0047173; GO:0050896; GO:0001972; GO:0042573; GO:0019841; GO:0042572; GO:0005791; GO:0007601; GO:0006776 embryo development; endoplasmic reticulum membrane; integral to membrane; multivesicular body; perinuclear region of cytoplasm; phosphatidylcholine-retinol O-acyltransferase activity; response to stimulus; retinoic acid binding; retinoic acid metabolic process; retinol binding; retinol metabolic process; rough endoplasmic reticulum; visual perception; vitamin A metabolic process IPR007053; Cofactor metabolism; retinol metabolism. Lecithin retinol acyltransferase (EC 2.3.1.135) (Phosphatidylcholine--retinol O-acyltransferase) Lrat Rattus norvegicus (Rat) TR33379_c0_g5_i4 P53817 PAG16_RAT 5.00E-11 GO:0052740; GO:0005737; GO:0005783; GO:0016021; GO:0016042; GO:0016020; GO:0045786; GO:0048471; GO:0008970; GO:0052739; GO:0004623; GO:0008654 1-acyl-2-lysophosphatidylserine acylhydrolase activity; cytoplasm; endoplasmic reticulum; integral to membrane; lipid catabolic process; membrane; negative regulation of cell cycle; perinuclear region of cytoplasm; phosphatidylcholine 1-acylhydrolase activity; phosphatidylserine 1-acylhydrolase activity; phospholipase A2 activity; phospholipid biosynthetic process IPR007053; HRAS-like suppressor 3 (HRSL3) (EC 3.1.1.32) (EC 3.1.1.4) (Group XVI phospholipase A1/A2) (H-rev 107 protein) Pla2g16 H-rev107 Hrasls3 Hrev107 Rattus norvegicus (Rat) TR33381_c0_g2_i1 O46106 NOI_DROME 4.00E-09 GO:0005686; GO:0071013; GO:0009566; GO:0000398; GO:0007067; GO:0007052; GO:0003676; GO:0051533; GO:0071011; GO:0051726; GO:0008270 "U2 snRNP; catalytic step 2 spliceosome; fertilization; mRNA splicing, via spliceosome; mitosis; mitotic spindle organization; nucleic acid binding; positive regulation of NFAT protein import into nucleus; precatalytic spliceosome; regulation of cell cycle; zinc ion binding" IPR024598; IPR021966; IPR015880; IPR000690; Splicing factor 3A subunit 3 (Protein noisette) noi CG2925 Drosophila melanogaster (Fruit fly) TR33381_c0_g3_i1 Q07G43 SDE2_XENTR 1.00E-41 IPR024974; Protein SDE2 homolog sde2 TEgg019d03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33381_c0_g3_i2 Q5BJN8 SDE2_RAT 7.00E-37 IPR024974; Protein SDE2 homolog Sde2 Rattus norvegicus (Rat) TR33382_c3_g2_i2 Q8BGV4 TTI2_MOUSE 6.00E-51 IPR016024; IPR018870; TELO2-interacting protein 2 Tti2 Mus musculus (Mouse) TR33384_c0_g2_i13 P14106 C1QB_MOUSE 6.00E-06 GO:0005581; GO:0006958; GO:0045087; GO:0048839; GO:0042803 "collagen; complement activation, classical pathway; innate immune response; inner ear development; protein homodimerization activity" IPR001073; IPR008160; IPR008983; Complement C1q subcomponent subunit B C1qb Mus musculus (Mouse) TR33384_c0_g2_i15 Q7LZR2 CO8A1_CHICK 6.00E-13 GO:0001525; GO:0005604; GO:0007155; GO:0005581 angiogenesis; basement membrane; cell adhesion; collagen IPR001073; IPR008160; IPR008983; Collagen alpha-1(VIII) chain COL8A1 Gallus gallus (Chicken) TR33384_c0_g2_i16 P08125 COAA1_CHICK 1.00E-09 GO:0005581; GO:0005576 collagen; extracellular region IPR001073; IPR008160; IPR008983; Collagen alpha-1(X) chain COL10A1 Gallus gallus (Chicken) TR33384_c0_g2_i2 Q05306 COAA1_MOUSE 6.00E-11 GO:0005938; GO:0005581 cell cortex; collagen IPR001073; IPR008160; IPR008983; Collagen alpha-1(X) chain Col10a1 Mus musculus (Mouse) TR33384_c0_g2_i4 Q06577 HP27_TAMSI 2.00E-06 GO:0005581; GO:0042750 collagen; hibernation IPR001073; IPR008160; IPR008983; Hibernation-associated plasma protein HP-27 (Hibernator-specific blood complex 27 kDa subunit) Tamias sibiricus (Siberian chipmunk) (Eutamias sibiricus) TR33384_c0_g2_i6 Q7LZR2 CO8A1_CHICK 5.00E-13 GO:0001525; GO:0005604; GO:0007155; GO:0005581 angiogenesis; basement membrane; cell adhesion; collagen IPR001073; IPR008160; IPR008983; Collagen alpha-1(VIII) chain COL8A1 Gallus gallus (Chicken) TR33384_c0_g2_i9 Q6UW01 CBLN3_HUMAN 4.00E-09 GO:0005794; GO:0030054; GO:0005783; GO:0005615; GO:0045202 Golgi apparatus; cell junction; endoplasmic reticulum; extracellular space; synapse IPR001073; IPR008983; Cerebellin-3 CBLN3 UNQ755/PRO1486 Homo sapiens (Human) TR33385_c0_g1_i1 Q6AXX4 SAS10_RAT 4.00E-11 GO:0007420; GO:0016568; GO:0005730; GO:0005634 brain development; chromatin modification; nucleolus; nucleus IPR007146; IPR018972; Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (Disrupter of silencing SAS10) (UTP3 homolog) Utp3 Crlz1 Sas10 Rattus norvegicus (Rat) TR33385_c0_g1_i2 Q4KLC4 NGDNA_XENLA 2.00E-71 GO:0005737; GO:0005634; GO:0006417 cytoplasm; nucleus; regulation of translation IPR007146; Neuroguidin-A (EIF4E-binding protein A) ngdn-a Xenopus laevis (African clawed frog) TR33386_c5_g1_i3 Q5HZM3 BAFL_XENLA 1.00E-38 GO:0003677; GO:0005634 DNA binding; nucleus IPR004122; Barrier-to-autointegration factor-like protein (BAF-L) (Barrier-to-autointegration factor 2) banf2 bafl Xenopus laevis (African clawed frog) TR33386_c5_g1_i4 Q9VLU0 BAF_DROME 1.00E-39 GO:0003677; GO:0005694; GO:0005737; GO:0030717; GO:0005635; GO:0005654 DNA binding; chromosome; cytoplasm; karyosome formation; nuclear envelope; nucleoplasm IPR004122; Barrier-to-autointegration factor baf CG7380 Drosophila melanogaster (Fruit fly) TR33388_c0_g1_i1 Q82851 POL_JEMBR 6.00E-07 GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0075713; GO:0004533; GO:0090305; GO:0006508; GO:0004523; GO:0039660; GO:0046718; GO:0019013; GO:0046797; GO:0008270 DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; establishment of integrated proviral latency; exoribonuclease H activity; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; structural constituent of virion; viral entry into host cell; viral nucleocapsid; viral procapsid maturation; zinc ion binding IPR001969; IPR000721; IPR001037; IPR001584; IPR017856; IPR003308; IPR018061; IPR001995; IPR021109; IPR008916; IPR008919; IPR012337; IPR002156; IPR000477; IPR010659; IPR010661; IPR001878; Gag-Pol polyprotein (Pr170Gag-Pol) [Cleaved into: Matrix protein p16 (MA); Capsid protein p26 (CA); Transframe peptide (p11); Protease (EC 3.4.23.-) (P119) (Retropepsin); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (P72); Integrase (IN)] gag-pol Jembrana disease virus (JDV) TR33388_c2_g1_i1 P04323 POL3_DROME 2.00E-44 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR33388_c3_g2_i1 P27401 POL_SFV3L 7.00E-10 GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0075713; GO:0030430; GO:0042025; GO:0046872; GO:0090305; GO:0006508; GO:0004523; GO:0046718; GO:0075732; GO:0019012 DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; establishment of integrated proviral latency; host cell cytoplasm; host cell nucleus; metal ion binding; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; viral entry into host cell; viral penetration into host nucleus; virion IPR001584; IPR012337; IPR002156; IPR000477; IPR001641; IPR015416; Pro-Pol polyprotein (Pr125Pol) [Cleaved into: Protease/Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (EC 3.4.23.-) (p87Pro-RT-RNaseH); Protease/Reverse transcriptase (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.4.23.-) (p65Pro-RT); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN) (p42In)] pol Simian foamy virus type 3 (strain LK3) (SFVagm) (SFV-3) TR33389_c0_g1_i1 P36514 UD2C1_RABIT 8.00E-50 GO:0005789; GO:0015020; GO:0016021 endoplasmic reticulum membrane; glucuronosyltransferase activity; integral to membrane IPR002213; UDP-glucuronosyltransferase 2C1 (UDPGT 2C1) (EC 2.4.1.17) (Fragment) UGT2C1 UGT2A2 Oryctolagus cuniculus (Rabbit) TR33389_c0_g1_i2 P36514 UD2C1_RABIT 7.00E-50 GO:0005789; GO:0015020; GO:0016021 endoplasmic reticulum membrane; glucuronosyltransferase activity; integral to membrane IPR002213; UDP-glucuronosyltransferase 2C1 (UDPGT 2C1) (EC 2.4.1.17) (Fragment) UGT2C1 UGT2A2 Oryctolagus cuniculus (Rabbit) TR33389_c0_g1_i4 Q5NTH0 UGAT_BELPE 3.00E-07 GO:0005737; GO:0016758 "cytoplasm; transferase activity, transferring hexosyl groups" IPR002213; Cyanidin-3-O-glucoside 2-O-glucuronosyltransferase (BpUGAT) (EC 2.4.1.254) (UDP-glucuronic acid:anthocyanin glucuronosyltransferase) UGAT UGT94B1 Bellis perennis (Daisy) TR33390_c1_g1_i1 O62742 NLTP_RABIT 1.00E-140 GO:0006869; GO:0005739; GO:0005777; GO:0033814; GO:0032934 lipid transport; mitochondrion; peroxisome; propanoyl-CoA C-acyltransferase activity; sterol binding IPR003033; IPR016039; IPR016038; IPR020615; IPR020617; IPR020613; IPR020616; Non-specific lipid-transfer protein (NSL-TP) (EC 2.3.1.176) (Propanoyl-CoA C-acyltransferase) (SCP-chi) (SCPX) (Sterol carrier protein 2) (SCP-2) (Sterol carrier protein X) (SCP-X) SCP2 Oryctolagus cuniculus (Rabbit) TR33393_c1_g2_i1 P97479 MYO7A_MOUSE 7.00E-121 GO:0005524; GO:0030048; GO:0016324; GO:0060088; GO:0005516; GO:0005938; GO:0005829; GO:0050957; GO:0006886; GO:0005765; GO:0007040; GO:0042470; GO:0000146; GO:0016459; GO:0001845; GO:0032391; GO:0001917; GO:0001750; GO:0051904; GO:0048563; GO:0007605; GO:0032420; GO:0045202; GO:0007601 Q80T11 ATP binding; actin filament-based movement; apical plasma membrane; auditory receptor cell stereocilium organization; calmodulin binding; cell cortex; cytosol; equilibrioception; intracellular protein transport; lysosomal membrane; lysosome organization; melanosome; microfilament motor activity; myosin complex; phagolysosome assembly; photoreceptor connecting cilium; photoreceptor inner segment; photoreceptor outer segment; pigment granule transport; post-embryonic organ morphogenesis; sensory perception of sound; stereocilium; synapse; visual perception IPR019749; IPR014352; IPR019748; IPR000299; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; IPR001452; Unconventional myosin-VIIa Myo7a Myo7 Mus musculus (Mouse) TR33393_c1_g2_i3 Q17LW0 MYO7A_AEDAE 0 GO:0005524; GO:0030048; GO:0030898; GO:0048800; GO:0008407; GO:0005737; GO:0035317; GO:0003774; GO:0016459; GO:0032027; GO:0007605 ATP binding; actin filament-based movement; actin-dependent ATPase activity; antennal morphogenesis; chaeta morphogenesis; cytoplasm; imaginal disc-derived wing hair organization; motor activity; myosin complex; myosin light chain binding; sensory perception of sound IPR019749; IPR014352; IPR019748; IPR000299; IPR018979; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; IPR001452; Myosin-VIIa (Protein crinkled) ck AAEL001220 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR33393_c1_g2_i4 P97479 MYO7A_MOUSE 5.00E-122 GO:0005524; GO:0030048; GO:0016324; GO:0060088; GO:0005516; GO:0005938; GO:0005829; GO:0050957; GO:0006886; GO:0005765; GO:0007040; GO:0042470; GO:0000146; GO:0016459; GO:0001845; GO:0032391; GO:0001917; GO:0001750; GO:0051904; GO:0048563; GO:0007605; GO:0032420; GO:0045202; GO:0007601 Q80T11 ATP binding; actin filament-based movement; apical plasma membrane; auditory receptor cell stereocilium organization; calmodulin binding; cell cortex; cytosol; equilibrioception; intracellular protein transport; lysosomal membrane; lysosome organization; melanosome; microfilament motor activity; myosin complex; phagolysosome assembly; photoreceptor connecting cilium; photoreceptor inner segment; photoreceptor outer segment; pigment granule transport; post-embryonic organ morphogenesis; sensory perception of sound; stereocilium; synapse; visual perception IPR019749; IPR014352; IPR019748; IPR000299; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; IPR001452; Unconventional myosin-VIIa Myo7a Myo7 Mus musculus (Mouse) TR33393_c1_g2_i5 Q17LW0 MYO7A_AEDAE 0 GO:0005524; GO:0030048; GO:0030898; GO:0048800; GO:0008407; GO:0005737; GO:0035317; GO:0003774; GO:0016459; GO:0032027; GO:0007605 ATP binding; actin filament-based movement; actin-dependent ATPase activity; antennal morphogenesis; chaeta morphogenesis; cytoplasm; imaginal disc-derived wing hair organization; motor activity; myosin complex; myosin light chain binding; sensory perception of sound IPR019749; IPR014352; IPR019748; IPR000299; IPR018979; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; IPR001452; Myosin-VIIa (Protein crinkled) ck AAEL001220 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR33394_c0_g1_i1 Q4V8K2 CTBL1_RAT 0 GO:0000974; GO:0008380; GO:0006915; GO:0006397; GO:0043065; GO:0016445; GO:0005681 Prp19 complex; RNA splicing; apoptotic process; mRNA processing; positive regulation of apoptotic process; somatic diversification of immunoglobulins; spliceosomal complex IPR011989; IPR016024; IPR013180; Beta-catenin-like protein 1 (Nuclear-associated protein) (NAP) Ctnnbl1 Rattus norvegicus (Rat) TR33394_c0_g4_i2 O62703 CTBL1_BOVIN 7.00E-40 GO:0000974; GO:0008380; GO:0006915; GO:0006397; GO:0005681 Prp19 complex; RNA splicing; apoptotic process; mRNA processing; spliceosomal complex IPR011989; IPR016024; IPR013180; Beta-catenin-like protein 1 (Nuclear-associated protein) (NAP) (p14) CTNNBL1 Bos taurus (Bovine) TR33396_c5_g2_i1 O08710 THYG_MOUSE 1.00E-06 GO:0005576; GO:0005615; GO:0042446; GO:0015705; GO:0031641; GO:0030878; GO:0006590 extracellular region; extracellular space; hormone biosynthetic process; iodide transport; regulation of myelination; thyroid gland development; thyroid hormone generation IPR002018; IPR019819; IPR016324; IPR000716; IPR011641; Thyroglobulin (Tg) Tg Tgn Mus musculus (Mouse) TR33396_c5_g3_i1 P01267 THYG_BOVIN 5.00E-08 GO:0005615; GO:0042446; GO:0006590 extracellular space; hormone biosynthetic process; thyroid hormone generation IPR002018; IPR019819; IPR009030; IPR016324; IPR000716; IPR011641; Thyroglobulin (Tg) TG Bos taurus (Bovine) TR33396_c5_g3_i2 P01266 THYG_HUMAN 8.00E-07 GO:0005615; GO:0042446; GO:0015705; GO:0031641; GO:0007165; GO:0030878; GO:0006590 extracellular space; hormone biosynthetic process; iodide transport; regulation of myelination; signal transduction; thyroid gland development; thyroid hormone generation IPR002018; IPR019819; IPR016324; IPR000716; IPR011641; Thyroglobulin (Tg) TG Homo sapiens (Human) TR33397_c3_g1_i1 Q28HW9 CNEP1_XENTR 2.00E-122 GO:0071595; GO:0030154; GO:0005789; GO:0016021; GO:0007399; GO:0006998; GO:0031965; GO:0048471; GO:0010867; GO:0006470; GO:0004722 Nem1-Spo7 phosphatase complex; cell differentiation; endoplasmic reticulum membrane; integral to membrane; nervous system development; nuclear envelope organization; nuclear membrane; perinuclear region of cytoplasm; positive regulation of triglyceride biosynthetic process; protein dephosphorylation; protein serine/threonine phosphatase activity IPR011948; IPR023214; IPR004274; CTD nuclear envelope phosphatase 1 (EC 3.1.3.16) (Serine/threonine-protein phosphatase dullard) ctdnep1 dullard TEgg035l07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33397_c3_g1_i4 Q28HW9 CNEP1_XENTR 2.00E-122 GO:0071595; GO:0030154; GO:0005789; GO:0016021; GO:0007399; GO:0006998; GO:0031965; GO:0048471; GO:0010867; GO:0006470; GO:0004722 Nem1-Spo7 phosphatase complex; cell differentiation; endoplasmic reticulum membrane; integral to membrane; nervous system development; nuclear envelope organization; nuclear membrane; perinuclear region of cytoplasm; positive regulation of triglyceride biosynthetic process; protein dephosphorylation; protein serine/threonine phosphatase activity IPR011948; IPR023214; IPR004274; CTD nuclear envelope phosphatase 1 (EC 3.1.3.16) (Serine/threonine-protein phosphatase dullard) ctdnep1 dullard TEgg035l07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR3340_c0_g1_i1 Q70LM4 LGRD_BREPA 2.00E-08 GO:0017000; GO:0016853; GO:0016874; GO:0016491; GO:0031177 antibiotic biosynthetic process; isomerase activity; ligase activity; oxidoreductase activity; phosphopantetheine binding IPR010071; IPR009081; IPR025110; IPR020845; IPR000873; IPR001242; IPR013120; IPR016040; IPR010060; IPR020806; IPR006162; IPR010080; Antibiotic biosynthesis; gramicidin S biosynthesis. Linear gramicidin synthase subunit D [Includes: ATP-dependent D-leucine adenylase (D-LeuA) (D-Leucine activase); Leucine racemase [ATP-hydrolyzing] (EC 5.1.1.-); ATP-dependent tryptophan adenylase (TrpA) (Tryptophan activase); ATP-dependent glycine adenylase (GlyA) (Glycine activase); Linear gramicidin--PCP reductase (EC 1.-.-.-)] lgrD Brevibacillus parabrevis TR33401_c2_g1_i1 Q7ZUS1 VRK1_DANRE 4.00E-69 GO:0005524; GO:0090166; GO:0005795; GO:0051301; GO:0007067; GO:0005634; GO:0004674 ATP binding; Golgi disassembly; Golgi stack; cell division; mitosis; nucleus; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) vrk1 zgc:56266 Danio rerio (Zebrafish) (Brachydanio rerio) TR33401_c2_g2_i1 Q2YDN8 VRK3_BOVIN 9.00E-21 GO:0005524; GO:0005634; GO:0004672 ATP binding; nucleus; protein kinase activity IPR011009; IPR000719; Inactive serine/threonine-protein kinase VRK3 (Serine/threonine-protein pseudokinase VRK3) (Vaccinia-related kinase 3) VRK3 Bos taurus (Bovine) TR33401_c2_g2_i3 Q32PI1 VRK1_BOVIN 4.00E-31 GO:0005524; GO:0090166; GO:0005795; GO:0051301; GO:0007067; GO:0005634; GO:0046777; GO:0004674; GO:0005819 ATP binding; Golgi disassembly; Golgi stack; cell division; mitosis; nucleus; protein autophosphorylation; protein serine/threonine kinase activity; spindle IPR011009; IPR000719; IPR017441; IPR008271; Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) VRK1 Bos taurus (Bovine) TR33403_c0_g1_i1 Q8IYQ7 THNS1_HUMAN 0 IPR027417; IPR000623; IPR004450; IPR001926; IPR027456; Threonine synthase-like 1 (TSH1) THNSL1 Homo sapiens (Human) TR33405_c2_g1_i15 Q3E813 YL154_YEAST 1.00E-09 Uncharacterized protein YLR154C-G YLR154C-G smORF421 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33406_c4_g1_i1 Q8TI16 ECFA_METAC 2.00E-06 GO:0005524; GO:0006200; GO:0016887; GO:0005886; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; plasma membrane; transport IPR003593; IPR003439; IPR015856; IPR027417; Energy-coupling factor transporter ATP-binding protein EcfA (ECF transporter A component EcfA) (EC 3.6.3.-) ecfA cbiO MA_4341 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) TR33406_c4_g3_i1 Q9NRK6 ABCBA_HUMAN 4.00E-101 GO:0005524; GO:0032592; GO:0005743; GO:0015421 ATP binding; integral to mitochondrial membrane; mitochondrial inner membrane; oligopeptide-transporting ATPase activity IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; "ATP-binding cassette sub-family B member 10, mitochondrial (ATP-binding cassette transporter 10) (ABC transporter 10 protein) (Mitochondrial ATP-binding cassette 2) (M-ABC2)" ABCB10 Homo sapiens (Human) TR33407_c0_g1_i1 O42586 PR6AB_XENLA 0 GO:0005524; GO:0005737; GO:0017111; GO:0005634; GO:0022624; GO:0030163 ATP binding; cytoplasm; nucleoside-triphosphatase activity; nucleus; proteasome accessory complex; protein catabolic process IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 6A-B (26S proteasome AAA-ATPase subunit RPT5-B) (Proteasome 26S subunit ATPase 3-B) (Tat-binding protein 10) (TBP-10) psmc3-b tbp10 Xenopus laevis (African clawed frog) TR33407_c0_g1_i2 Q63569 PRS6A_RAT 0 GO:0005524; GO:0001824; GO:0000932; GO:0017111; GO:0005634; GO:0048471; GO:0022624; GO:0030163 ATP binding; blastocyst development; cytoplasmic mRNA processing body; nucleoside-triphosphatase activity; nucleus; perinuclear region of cytoplasm; proteasome accessory complex; protein catabolic process IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Spermatogenic cell/sperm-associated Tat-binding protein homolog SATA) (Tat-binding protein 1) (TBP-1) Psmc3 Tbp1 Rattus norvegicus (Rat) TR33407_c0_g1_i3 Q63569 PRS6A_RAT 0 GO:0005524; GO:0001824; GO:0000932; GO:0017111; GO:0005634; GO:0048471; GO:0022624; GO:0030163 ATP binding; blastocyst development; cytoplasmic mRNA processing body; nucleoside-triphosphatase activity; nucleus; perinuclear region of cytoplasm; proteasome accessory complex; protein catabolic process IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Spermatogenic cell/sperm-associated Tat-binding protein homolog SATA) (Tat-binding protein 1) (TBP-1) Psmc3 Tbp1 Rattus norvegicus (Rat) TR33408_c11_g1_i1 A8MXQ7 YH010_HUMAN 2.00E-18 IPR002110; IPR020683; IPR000048; Putative IQ motif and ankyrin repeat domain-containing protein LOC642574 Homo sapiens (Human) TR33408_c13_g1_i1 Q9CQS5 RIOK2_MOUSE 2.00E-132 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR018934; IPR015285; IPR018935; IPR011991; Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) Riok2 Mus musculus (Mouse) TR33408_c6_g1_i1 Q0IH24 SPEF1_XENLA 2.00E-29 GO:0035085; GO:0005856 cilium axoneme; cytoskeleton IPR001715; IPR010441; Sperm flagellar protein 1 spef1 clamp Xenopus laevis (African clawed frog) TR33408_c8_g1_i1 O00602 FCN1_HUMAN 9.00E-50 GO:0003823; GO:0005509; GO:0030246; GO:0005581; GO:0001867; GO:0005576; GO:0008228 Q2TS39 "antigen binding; calcium ion binding; carbohydrate binding; collagen; complement activation, lectin pathway; extracellular region; opsonization" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) FCN1 FCNM Homo sapiens (Human) TR33409_c1_g1_i1 Q9UI26 IPO11_HUMAN 0 GO:0005737; GO:0005634; GO:0008565; GO:0006610 cytoplasm; nucleus; protein transporter activity; ribosomal protein import into nucleus IPR011989; IPR016024; IPR001494; Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11) IPO11 RANBP11 Homo sapiens (Human) TR33410_c0_g2_i1 Q9VUC6 Y2138_DROME 1.00E-153 GO:0003779; GO:0030036; GO:0048812 actin binding; actin cytoskeleton organization; neuron projection morphogenesis IPR016024; IPR014767; IPR015425; IPR010472; IPR010473; IPR014768; Formin-like protein CG32138 CG32138 Drosophila melanogaster (Fruit fly) TR33410_c0_g2_i2 Q80U19 DAAM2_MOUSE 3.00E-54 GO:0030036 actin cytoskeleton organization IPR016024; IPR027650; IPR014767; IPR015425; IPR010472; IPR010473; IPR014768; Disheveled-associated activator of morphogenesis 2 Daam2 Kiaa0381 Mus musculus (Mouse) TR33411_c0_g1_i1 P37610 TAUD_ECOLI 6.00E-10 GO:0031418; GO:0005737; GO:0046872; GO:0006790; GO:0000908 L-ascorbic acid binding; cytoplasm; metal ion binding; sulfur compound metabolic process; taurine dioxygenase activity IPR003819; Organosulfur degradation; taurine degradation via aerobic pathway; aminoacetaldehyde and sulfite from taurine: step 1/1. Alpha-ketoglutarate-dependent taurine dioxygenase (EC 1.14.11.17) (2-aminoethanesulfonate dioxygenase) (Sulfate starvation-induced protein 3) (SSI3) tauD ssiD yaiG b0368 JW0360 Escherichia coli (strain K12) TR33412_c5_g1_i1 Q8NQU9 UNG_CORGL 4.00E-20 GO:0006284; GO:0005737; GO:0004844 base-excision repair; cytoplasm; uracil DNA N-glycosylase activity IPR018085; IPR002043; IPR005122; Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) ung Cgl1324 cg1496 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) TR33412_c5_g1_i3 B0KV50 UNG_PSEPG 1.00E-71 GO:0006284; GO:0005737; GO:0004844 base-excision repair; cytoplasm; uracil DNA N-glycosylase activity IPR018085; IPR002043; IPR005122; Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) ung PputGB1_4397 Pseudomonas putida (strain GB-1) TR33412_c8_g3_i1 Q14376 GALE_HUMAN 2.00E-69 GO:0003978; GO:0044237; GO:0050662; GO:0005829; GO:0019388; GO:0044281 UDP-glucose 4-epimerase activity; cellular metabolic process; coenzyme binding; cytosol; galactose catabolic process; small molecule metabolic process IPR025308; IPR001509; IPR005886; IPR016040; IPR008089; Carbohydrate metabolism; galactose metabolism. UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-galactose 4-epimerase) GALE Homo sapiens (Human) TR33412_c8_g4_i1 Q9Y7X5 YGRE_SCHPO 2.00E-43 GO:0003978; GO:0050662; GO:0005829; GO:0033499; GO:0042125 UDP-glucose 4-epimerase activity; coenzyme binding; cytosol; galactose catabolic process via UDP-galactose; protein galactosylation IPR025308; IPR001509; IPR005886; IPR016040; Carbohydrate metabolism; galactose metabolism. UDP-glucose 4-epimerase uge1 (EC 5.1.3.2) (Galactowaldenase) uge1 SPBC365.14c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR33412_c8_g5_i2 P04397 GAL10_YEAST 1.00E-40 GO:0003978; GO:0004034; GO:0030246; GO:0044237; GO:0050662; GO:0005829; GO:0033499 UDP-glucose 4-epimerase activity; aldose 1-epimerase activity; carbohydrate binding; cellular metabolic process; coenzyme binding; cytosol; galactose catabolic process via UDP-galactose IPR018052; IPR008183; IPR025308; IPR001509; IPR011013; IPR005886; IPR014718; IPR016040; Carbohydrate metabolism; galactose metabolism. Carbohydrate metabolism; hexose metabolism. Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase); Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase)] GAL10 YBR019C YBR0301 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33415_c3_g1_i1 Q94360 NDUS7_CAEEL 5.00E-86 GO:0051539; GO:0008137; GO:0046872; GO:0005739; GO:0048038; GO:0070469 "4 iron, 4 sulfur cluster binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; mitochondrion; quinone binding; respiratory chain" IPR006137; IPR006138; "Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit)" nduf-7 W10D5.2 Caenorhabditis elegans TR33415_c3_g1_i2 P42026 NDUS7_BOVIN 2.00E-93 GO:0051539; GO:0008137; GO:0046872; GO:0005747; GO:0032981; GO:0048038 "4 iron, 4 sulfur cluster binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; mitochondrial respiratory chain complex I; mitochondrial respiratory chain complex I assembly; quinone binding" IPR006137; IPR006138; "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit)" NDUFS7 Bos taurus (Bovine) TR33415_c3_g1_i3 Q31CN9 NDHK_PROM9 4.00E-47 GO:0051539; GO:0008137; GO:0005506; GO:0019684; GO:0048038; GO:0042651; GO:0006810 "4 iron, 4 sulfur cluster binding; NADH dehydrogenase (ubiquinone) activity; iron ion binding; photosynthesis, light reaction; quinone binding; thylakoid membrane; transport" IPR006137; IPR006138; NAD(P)H-quinone oxidoreductase subunit K (EC 1.6.5.-) (NAD(P)H dehydrogenase I subunit K) (NDH-1 subunit K) (NDH-K) ndhK PMT9312_0295 Prochlorococcus marinus (strain MIT 9312) TR33415_c3_g1_i4 P42026 NDUS7_BOVIN 3.00E-93 GO:0051539; GO:0008137; GO:0046872; GO:0005747; GO:0032981; GO:0048038 "4 iron, 4 sulfur cluster binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; mitochondrial respiratory chain complex I; mitochondrial respiratory chain complex I assembly; quinone binding" IPR006137; IPR006138; "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit)" NDUFS7 Bos taurus (Bovine) TR33415_c5_g1_i3 Q2LZ37 WLS_DROPS 5.00E-30 GO:0016055; GO:0017147; GO:0030054; GO:0008587; GO:0005887; GO:0030285; GO:0031228; GO:0031227; GO:0031302; GO:0031594; GO:0030177; GO:0050714; GO:0045211; GO:0042734; GO:0033157; GO:0007367 Wnt receptor signaling pathway; Wnt-protein binding; cell junction; imaginal disc-derived wing margin morphogenesis; integral to plasma membrane; integral to synaptic vesicle membrane; intrinsic to Golgi membrane; intrinsic to endoplasmic reticulum membrane; intrinsic to endosome membrane; neuromuscular junction; positive regulation of Wnt receptor signaling pathway; positive regulation of protein secretion; postsynaptic membrane; presynaptic membrane; regulation of intracellular protein transport; segment polarity determination IPR009551; Protein wntless wls GA19442 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR33415_c5_g2_i1 P21328 RTJK_DROME 2.00E-08 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) TR33416_c0_g1_i1 Q7Z8P9 NDK_ASPFU 2.00E-70 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0046872; GO:0005739; GO:0004550 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; metal ion binding; mitochondrion; nucleoside diphosphate kinase activity IPR001564; IPR023005; Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) ndk1 AFUA_5G03490 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) TR33417_c0_g3_i1 Q6PGZ3 MIPT3_DANRE 5.00E-42 GO:0042384; GO:0005737; GO:0005856; GO:0048793 cilium assembly; cytoplasm; cytoskeleton; pronephros development IPR018799; TRAF3-interacting protein 1 traf3ip1 zgc:63522 Danio rerio (Zebrafish) (Brachydanio rerio) TR33417_c3_g1_i2 Q6PGZ3 MIPT3_DANRE 2.00E-47 GO:0042384; GO:0005737; GO:0005856; GO:0048793 cilium assembly; cytoplasm; cytoskeleton; pronephros development IPR018799; TRAF3-interacting protein 1 traf3ip1 zgc:63522 Danio rerio (Zebrafish) (Brachydanio rerio) TR33418_c1_g1_i1 Q6RY07 CHIA_RAT 2.00E-133 GO:0006915; GO:0008061; GO:0006032; GO:0004568; GO:0005737; GO:0005615; GO:0000272; GO:0090197; GO:0002532 apoptotic process; chitin binding; chitin catabolic process; chitinase activity; cytoplasm; extracellular space; polysaccharide catabolic process; positive regulation of chemokine secretion; production of molecular mediator involved in inflammatory response IPR002557; IPR011583; IPR001223; IPR001579; IPR013781; IPR017853; Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) Chia Rattus norvegicus (Rat) TR33419_c3_g1_i1 Q21890 YF64_CAEEL 1.00E-46 GO:0006520; GO:0016829; GO:0030170 cellular amino acid metabolic process; lyase activity; pyridoxal phosphate binding IPR001597; IPR015424; IPR015421; IPR015422; IPR023603; Uncharacterized protein R102.4 R102.4 Caenorhabditis elegans TR33419_c4_g1_i1 Q5R9W6 TAF13_PONAB 2.00E-51 GO:0003677; GO:0005730; GO:0006355; GO:0005669; GO:0006366 "DNA binding; nucleolus; regulation of transcription, DNA-dependent; transcription factor TFIID complex; transcription from RNA polymerase II promoter" IPR009072; IPR003195; Transcription initiation factor TFIID subunit 13 (Transcription initiation factor TFIID 18 kDa subunit) (TAF(II)18) (TAFII-18) (TAFII18) TAF13 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33419_c4_g1_i2 Q5R9W6 TAF13_PONAB 1.00E-51 GO:0003677; GO:0005730; GO:0006355; GO:0005669; GO:0006366 "DNA binding; nucleolus; regulation of transcription, DNA-dependent; transcription factor TFIID complex; transcription from RNA polymerase II promoter" IPR009072; IPR003195; Transcription initiation factor TFIID subunit 13 (Transcription initiation factor TFIID 18 kDa subunit) (TAF(II)18) (TAFII-18) (TAFII18) TAF13 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33420_c0_g2_i1 Q9Y4D8 HECD4_HUMAN 0 GO:0005737; GO:0016021; GO:0005634; GO:0042787; GO:0004842 cytoplasm; integral to membrane; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000569; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HECTD4 (EC 6.3.2.-) (HECT domain-containing protein 4) HECTD4 C12orf51 KIAA0614 Homo sapiens (Human) TR33420_c0_g3_i2 O95714 HERC2_HUMAN 2.00E-24 GO:0006281; GO:0032183; GO:0005814; GO:0005737; GO:0005085; GO:0020037; GO:0006886; GO:0005634; GO:0042787; GO:0004842; GO:0008270 DNA repair; SUMO binding; centriole; cytoplasm; guanyl-nucleotide exchange factor activity; heme binding; intracellular protein transport; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR004939; IPR006624; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) HERC2 Homo sapiens (Human) TR33420_c0_g3_i3 F8W2M1 HACE1_DANRE 1.00E-20 GO:0032580; GO:0000139; GO:0007030; GO:0017137; GO:0007049; GO:0005783; GO:0061025; GO:0070936; GO:0042787; GO:0030334; GO:0004842 Golgi cisterna membrane; Golgi membrane; Golgi organization; Rab GTPase binding; cell cycle; endoplasmic reticulum; membrane fusion; protein K48-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of cell migration; ubiquitin-protein ligase activity IPR002110; IPR020683; IPR000569; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HACE1 (EC 6.3.2.-) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) hace1 Danio rerio (Zebrafish) (Brachydanio rerio) TR33420_c0_g3_i4 Q08CZ0 UBE3B_XENTR 1.00E-09 GO:0004842 ubiquitin-protein ligase activity IPR000569; IPR000048; Protein modification; protein ubiquitination. Ubiquitin-protein ligase E3B (EC 6.3.2.-) ube3b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33420_c0_g3_i5 Q9Y4D8 HECD4_HUMAN 5.00E-115 GO:0005737; GO:0016021; GO:0005634; GO:0042787; GO:0004842 cytoplasm; integral to membrane; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000569; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HECTD4 (EC 6.3.2.-) (HECT domain-containing protein 4) HECTD4 C12orf51 KIAA0614 Homo sapiens (Human) TR33420_c0_g3_i6 Q15751 HERC1_HUMAN 6.00E-27 GO:0005086; GO:0005794; GO:0021702; GO:0005829; GO:0016020; GO:0010507; GO:0050885; GO:0031175; GO:0006810; GO:0004842 ARF guanyl-nucleotide exchange factor activity; Golgi apparatus; cerebellar Purkinje cell differentiation; cytosol; membrane; negative regulation of autophagy; neuromuscular process controlling balance; neuron projection development; transport; ubiquitin-protein ligase activity IPR001870; IPR008985; IPR000569; IPR009091; IPR000408; IPR018355; IPR003877; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HERC1 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 1) (p532) (p619) HERC1 Homo sapiens (Human) TR33423_c1_g1_i2 A2AGT5 CKAP5_MOUSE 2.00E-89 GO:0050658; GO:0051301; GO:0005737; GO:0005815; GO:0007067; GO:0043234; GO:0000922 RNA transport; cell division; cytoplasm; microtubule organizing center; mitosis; protein complex; spindle pole IPR011989; IPR016024; IPR024395; IPR021133; Cytoskeleton-associated protein 5 Ckap5 Mus musculus (Mouse) TR33423_c2_g1_i2 Q94FN2 MOR1_ARATH 6.00E-29 GO:0009920; GO:0030981; GO:0005874; GO:0008017; GO:0009524; GO:0009506; GO:0009574; GO:0005819 cell plate formation involved in plant-type cell wall biogenesis; cortical microtubule cytoskeleton; microtubule; microtubule binding; phragmoplast; plasmodesma; preprophase band; spindle IPR011989; IPR016024; IPR024395; IPR021133; Protein MOR1 (Protein GEM1) (Protein GEMINI POLLEN 1) (Protein MICROTUBULE ORGANIZATION 1) (Protein RID5) (Protein ROOT INITIATION DEFECTIVE 5) MOR1 GEM1 RID5 At2g35630 T20F21.17 Arabidopsis thaliana (Mouse-ear cress) TR33423_c4_g1_i1 Q14008 CKAP5_HUMAN 5.00E-29 GO:0000086; GO:0050658; GO:0051301; GO:0005813; GO:0051297; GO:0005829; GO:0030951; GO:0007067; GO:0007051; GO:0000922 P16333; O75410; O75410-1; O75410-6; Q9Y6A5 G2/M transition of mitotic cell cycle; RNA transport; cell division; centrosome; centrosome organization; cytosol; establishment or maintenance of microtubule cytoskeleton polarity; mitosis; spindle organization; spindle pole IPR011989; IPR016024; IPR024395; IPR000357; IPR021133; Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) CKAP5 KIAA0097 Homo sapiens (Human) TR33424_c0_g2_i1 P30043 BLVRB_HUMAN 5.00E-15 GO:0004074; GO:0005829; GO:0042167; GO:0005634; GO:0005886; GO:0042602; GO:0044281 biliverdin reductase activity; cytosol; heme catabolic process; nucleus; plasma membrane; riboflavin reductase (NADPH) activity; small molecule metabolic process IPR016040 Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.24) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) BLVRB FLR Homo sapiens (Human) TR33427_c4_g1_i1 Q8BZZ3 WWP1_MOUSE 6.00E-09 GO:0030217; GO:0005737; GO:0030324; GO:0045892; GO:0005634; GO:0005886; GO:0043161; GO:0042787; GO:0004842 "T cell differentiation; cytoplasm; lung development; negative regulation of transcription, DNA-dependent; nucleus; plasma membrane; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity" IPR000008; IPR024928; IPR000569; IPR001202; Protein modification; protein ubiquitination. NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain-containing protein 1) Wwp1 Mus musculus (Mouse) TR33427_c6_g1_i1 E1B7X9 SMRCD_BOVIN 1.00E-120 GO:0005524; GO:0043044; GO:0003677; GO:0000729; GO:0051304; GO:0004386; GO:0000792; GO:0070932; GO:0070933; GO:0005634; GO:0035861 ATP binding; ATP-dependent chromatin remodeling; DNA binding; DNA double-strand break processing; chromosome separation; helicase activity; heterochromatin; histone H3 deacetylation; histone H4 deacetylation; nucleus; site of double-strand break IPR003892; IPR014001; IPR001650; IPR027417; IPR000330; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.4.12) SMARCAD1 Bos taurus (Bovine) TR33427_c7_g1_i1 Q9H4L7 SMRCD_HUMAN 1.00E-10 GO:0005524; GO:0043044; GO:0003677; GO:0000729; GO:0051304; GO:0004386; GO:0000792; GO:0070932; GO:0070933; GO:0016363; GO:0043596; GO:0009117; GO:0045893; GO:0051260; GO:0000018; GO:0035861 "ATP binding; ATP-dependent chromatin remodeling; DNA binding; DNA double-strand break processing; chromosome separation; helicase activity; heterochromatin; histone H3 deacetylation; histone H4 deacetylation; nuclear matrix; nuclear replication fork; nucleotide metabolic process; positive regulation of transcription, DNA-dependent; protein homooligomerization; regulation of DNA recombination; site of double-strand break" IPR003892; IPR014001; IPR001650; IPR027417; IPR000330; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) SMARCAD1 KIAA1122 Homo sapiens (Human) TR33432_c4_g1_i1 Q8N5I4 DHRSX_HUMAN 6.00E-68 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Dehydrogenase/reductase SDR family member on chromosome X (EC 1.1.-.-) (DHRSXY) DHRSX CXorf11 DHRS5X UNQ6508/PRO21433 Homo sapiens (Human) TR33433_c0_g1_i1 P08953 TOLL_DROME 1.00E-06 GO:0033565; GO:0008063; GO:0019732; GO:0007155; GO:0019955; GO:0050830; GO:0005769; GO:0009897; GO:0007507; GO:0035172; GO:0030097; GO:0045087; GO:0016021; GO:0006963; GO:0006967; GO:0045610; GO:0007416; GO:0016201; GO:0004888; GO:0007352 Itself; Q7K105 ESCRT-0 complex; Toll signaling pathway; antifungal humoral response; cell adhesion; cytokine binding; defense response to Gram-positive bacterium; early endosome; external side of plasma membrane; heart development; hemocyte proliferation; hemopoiesis; innate immune response; integral to membrane; positive regulation of antibacterial peptide biosynthetic process; positive regulation of antifungal peptide biosynthetic process; regulation of hemocyte differentiation; synapse assembly; synaptic target inhibition; transmembrane signaling receptor activity; zygotic specification of dorsal/ventral axis IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) TR33434_c0_g1_i5 Q8BGE6 ATG4B_MOUSE 4.00E-123 GO:0000045; GO:0006914; GO:0004197; GO:0005737; GO:0010508; GO:0015031; GO:0006508 autophagic vacuole assembly; autophagy; cysteine-type endopeptidase activity; cytoplasm; positive regulation of autophagy; protein transport; proteolysis IPR005078; Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagin-1) (Autophagy-related cysteine endopeptidase 1) (Autophagy-related protein 4 homolog B) Atg4b Apg4b Autl1 Kiaa0943 Mus musculus (Mouse) TR33435_c1_g1_i3 Q9ES64 USH1C_MOUSE 2.00E-14 GO:0042491; GO:0005856; GO:0005829; GO:0042472; GO:0050885; GO:0030046; GO:0001917; GO:0001750; GO:0005886; GO:0007605; GO:0032420; GO:0045202 Q99PF4; Q99PJ1; Q80T11 auditory receptor cell differentiation; cytoskeleton; cytosol; inner ear morphogenesis; neuromuscular process controlling balance; parallel actin filament bundle assembly; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; sensory perception of sound; stereocilium; synapse IPR001478; Harmonin (PDZ domain-containing protein) (Usher syndrome type-1C protein homolog) Ush1c Mus musculus (Mouse) TR33436_c0_g1_i1 B3QVL0 GPMA_CHLT3 9.00E-91 GO:0046538; GO:0006096 "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity; glycolysis" IPR013078; IPR001345; IPR005952; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (BPG-dependent PGAM) (PGAM) (Phosphoglyceromutase) (dPGM) (EC 5.4.2.11)" gpmA Ctha_2159 Chloroherpeton thalassium (strain ATCC 35110 / GB-78) TR33438_c0_g1_i3 Q62210 BIRC2_MOUSE 1.00E-14 GO:0035631; GO:0006915; GO:0005737; GO:0009898; GO:0070266; GO:0060546; GO:1902443; GO:0005634; GO:0001890; GO:0043123; GO:0043161; GO:0070936; GO:0070534; GO:0042981; GO:0051726; GO:2000377; GO:0006355; GO:0003713; GO:0006351; GO:0004842; GO:0008270 "CD40 receptor complex; apoptotic process; cytoplasm; internal side of plasma membrane; necroptosis; negative regulation of necroptosis; negative regulation of ripoptosome assembly involved in necroptosis; nucleus; placenta development; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; protein K63-linked ubiquitination; regulation of apoptotic process; regulation of cell cycle; regulation of reactive oxygen species metabolic process; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (Inhibitor of apoptosis protein 2) (IAP-2) (mIAP-2) (mIAP2) Birc2 Birc3 Iap2 Mus musculus (Mouse) TR33438_c0_g1_i4 Q13490 BIRC2_HUMAN 3.00E-17 GO:0035631; GO:0038061; GO:0035666; GO:0007166; GO:0006921; GO:0005829; GO:0045087; GO:0009898; GO:0070266; GO:0043066; GO:0005634; GO:0001890; GO:0043123; GO:0043161; GO:0000209; GO:0039535; GO:0051726; GO:0045595; GO:0042127; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0006355; GO:0034138; GO:0034142; GO:0003713; GO:0006351; GO:0004842; GO:0008270 P55210; Q9NR28; P63000; Q13546; O43353; Q9Y572; P57078; Q9NP84; Q12933 "CD40 receptor complex; NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; cell surface receptor signaling pathway; cellular component disassembly involved in execution phase of apoptosis; cytosol; innate immune response; internal side of plasma membrane; necroptosis; negative regulation of apoptotic process; nucleus; placenta development; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of RIG-I signaling pathway; regulation of cell cycle; regulation of cell differentiation; regulation of cell proliferation; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; regulation of transcription, DNA-dependent; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (IAP-2) (hIAP-2) (hIAP2) (RING finger protein 48) (TNFR2-TRAF-signaling complex protein 2) BIRC2 API1 IAP2 MIHB RNF48 Homo sapiens (Human) TR33438_c0_g1_i6 A1E2V0 BIRC3_CANFA 1.00E-14 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) BIRC3 Canis familiaris (Dog) (Canis lupus familiaris) TR33442_c0_g2_i2 Q3TTL0 CC038_MOUSE 4.00E-47 GO:0006915 apoptotic process IPR026698; Uncharacterized protein C3orf38 homolog Mus musculus (Mouse) TR33444_c3_g1_i1 O46160 RL14_LUMRU 1.00E-53 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR014722; IPR002784; IPR008991; 60S ribosomal protein L14 RPL14 Lumbricus rubellus (Humus earthworm) TR33446_c1_g1_i1 Q4V8V1 BM1LA_DANRE 5.00E-24 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR013907; Breast cancer metastasis-suppressor 1-like protein-A brms1la brms1l zgc:114129 Danio rerio (Zebrafish) (Brachydanio rerio) TR33446_c1_g1_i2 Q5RBB8 SDS3_PONAB 4.00E-77 GO:0006915; GO:0016575; GO:0005634; GO:0043065; GO:0006355; GO:0006351 "apoptotic process; histone deacetylation; nucleus; positive regulation of apoptotic process; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR013907; Sin3 histone deacetylase corepressor complex component SDS3 (Suppressor of defective silencing 3 protein homolog) SUDS3 SDS3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33447_c1_g1_i2 Q9ESQ4 NMUR2_RAT 2.00E-50 GO:0005525; GO:0043006; GO:0050482; GO:0006816; GO:0007417; GO:0007204; GO:0007625; GO:0048016; GO:0016021; GO:0005229; GO:0042924; GO:0001607; GO:0008188; GO:0007200; GO:0005886; GO:0002023; GO:0048265 GTP binding; activation of phospholipase A2 activity by calcium-mediated signaling; arachidonic acid secretion; calcium ion transport; central nervous system development; elevation of cytosolic calcium ion concentration; grooming behavior; inositol phosphate-mediated signaling; integral to membrane; intracellular calcium activated chloride channel activity; neuromedin U binding; neuromedin U receptor activity; neuropeptide receptor activity; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; reduction of food intake in response to dietary excess; response to pain IPR000276; IPR017452; IPR005390; IPR005392; Neuromedin-U receptor 2 (NMU-R2) (G-protein coupled receptor TGR-1) (G-protein-coupled receptor FM-4) Nmur2 Tgr1 Rattus norvegicus (Rat) TR33448_c2_g1_i2 Q8NHU2 CT026_HUMAN 2.00E-125 IPR016181 Uncharacterized protein C20orf26 C20orf26 Homo sapiens (Human) TR33449_c4_g1_i1 Q5E9J6 RNF34_BOVIN 4.00E-60 GO:0006915; GO:0012505; GO:0016874; GO:0016020; GO:0016607; GO:0016567; GO:0008270 apoptotic process; endomembrane system; ligase activity; membrane; nuclear speck; protein ubiquitination; zinc ion binding IPR011011; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF34 (EC 6.3.2.-) (RING finger protein 34) RNF34 Bos taurus (Bovine) TR33449_c4_g1_i2 Q5E9J6 RNF34_BOVIN 4.00E-60 GO:0006915; GO:0012505; GO:0016874; GO:0016020; GO:0016607; GO:0016567; GO:0008270 apoptotic process; endomembrane system; ligase activity; membrane; nuclear speck; protein ubiquitination; zinc ion binding IPR011011; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF34 (EC 6.3.2.-) (RING finger protein 34) RNF34 Bos taurus (Bovine) TR33449_c4_g1_i4 Q557E7 CBLA_DICDI 4.00E-10 GO:0005509; GO:0005829; GO:0007243; GO:0016874; GO:0005634; GO:0016567; GO:0030587; GO:0008270 calcium ion binding; cytosol; intracellular protein kinase cascade; ligase activity; nucleus; protein ubiquitination; sorocarp development; zinc ion binding IPR014741; IPR024159; IPR011992; IPR000980; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase cblA (EC 6.3.2.-) (Cbl-like protein A) (RING finger protein cblA) cblA-1 DDB_G0273141; cblA-2 DDB_G0273609 Dictyostelium discoideum (Slime mold) TR33451_c0_g1_i3 O93614 GDS1A_XENLA 1.00E-106 GO:0005096; GO:0005737; GO:0005856; GO:0043547; GO:0007264 GTPase activator activity; cytoplasm; cytoskeleton; positive regulation of GTPase activity; small GTPase mediated signal transduction IPR011989; IPR016024; IPR000225; Rap1 GTPase-GDP dissociation stimulator 1-A (Rap1gds1-A protein) (RalB-binding protein A) (XsmgGDS-A) (smgGDS-A) rap1gds1-a Xenopus laevis (African clawed frog) TR33453_c2_g1_i2 P11179 ODO2_BOVIN 3.00E-166 GO:0033512; GO:0004149; GO:0005739; GO:0045252; GO:0006099 L-lysine catabolic process to acetyl-CoA via saccharopine; dihydrolipoyllysine-residue succinyltransferase activity; mitochondrion; oxoglutarate dehydrogenase complex; tricarboxylic acid cycle IPR003016; IPR001078; IPR000089; IPR023213; IPR011053; IPR006255; Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6. "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K)" DLST Bos taurus (Bovine) TR33453_c2_g1_i3 P11179 ODO2_BOVIN 2.00E-166 GO:0033512; GO:0004149; GO:0005739; GO:0045252; GO:0006099 L-lysine catabolic process to acetyl-CoA via saccharopine; dihydrolipoyllysine-residue succinyltransferase activity; mitochondrion; oxoglutarate dehydrogenase complex; tricarboxylic acid cycle IPR003016; IPR001078; IPR000089; IPR023213; IPR011053; IPR006255; Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6. "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K)" DLST Bos taurus (Bovine) TR33454_c0_g1_i1 Q99PT3 IN80B_MOUSE 2.00E-24 GO:0006310; GO:0006281; GO:0031011; GO:0005737; GO:0046872; GO:0005730; GO:0005886; GO:0006355; GO:0006351 "DNA recombination; DNA repair; Ino80 complex; cytoplasm; metal ion binding; nucleolus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006880; IPR007529; INO80 complex subunit B (High mobility group AT-hook 1-like 4) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) Ino80b Hmga1l4 Papa1 Znhit4 Mus musculus (Mouse) TR33455_c0_g1_i1 Q91VS7 MGST1_MOUSE 1.00E-37 GO:0033327; GO:0045177; GO:0071449; GO:0005783; GO:0005789; GO:0043295; GO:0006749; GO:0004602; GO:0004364; GO:0016021; GO:0005743; GO:0005741; GO:0005634; GO:0005778; GO:0070207; GO:0042493; GO:0032496; GO:0010243 Leydig cell differentiation; apical part of cell; cellular response to lipid hydroperoxide; endoplasmic reticulum; endoplasmic reticulum membrane; glutathione binding; glutathione metabolic process; glutathione peroxidase activity; glutathione transferase activity; integral to membrane; mitochondrial inner membrane; mitochondrial outer membrane; nucleus; peroxisomal membrane; protein homotrimerization; response to drug; response to lipopolysaccharide; response to organonitrogen compound IPR023352; IPR001129; Microsomal glutathione S-transferase 1 (Microsomal GST-1) (EC 2.5.1.18) (Microsomal GST-I) Mgst1 Mus musculus (Mouse) TR33455_c0_g1_i2 P10620 MGST1_HUMAN 2.00E-41 GO:0033327; GO:0045177; GO:0071449; GO:0005789; GO:0043295; GO:1901687; GO:0006749; GO:0004602; GO:0004364; GO:0016021; GO:0005743; GO:0005741; GO:0005739; GO:0005634; GO:0005778; GO:0070207; GO:0042493; GO:0032496; GO:0010243; GO:0044281; GO:0006805 Q8WX92 Leydig cell differentiation; apical part of cell; cellular response to lipid hydroperoxide; endoplasmic reticulum membrane; glutathione binding; glutathione derivative biosynthetic process; glutathione metabolic process; glutathione peroxidase activity; glutathione transferase activity; integral to membrane; mitochondrial inner membrane; mitochondrial outer membrane; mitochondrion; nucleus; peroxisomal membrane; protein homotrimerization; response to drug; response to lipopolysaccharide; response to organonitrogen compound; small molecule metabolic process; xenobiotic metabolic process IPR023352; IPR001129; Microsomal glutathione S-transferase 1 (Microsomal GST-1) (EC 2.5.1.18) (Microsomal GST-I) MGST1 GST12 MGST Homo sapiens (Human) TR33457_c3_g1_i2 Q7ZYZ7 PCGF1_DANRE 7.00E-60 GO:0031519; GO:0006355; GO:0006351; GO:0008270 "PcG protein complex; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR018957; IPR001841; IPR013083; IPR017907; Polycomb group RING finger protein 1 pcgf1 si:zc207o21.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR33459_c0_g1_i1 P09957 YELL_DROME 8.00E-33 GO:0070451; GO:0048067; GO:0005737; GO:0005576; GO:0016853; GO:0048065; GO:0006583; GO:0048082 Q9W1D9 "cell hair; cuticle pigmentation; cytoplasm; extracellular region; isomerase activity; male courtship behavior, veined wing extension; melanin biosynthetic process from tyrosine; regulation of adult chitin-containing cuticle pigmentation" IPR011042; IPR017996; IPR003534; Protein yellow y CG3757 Drosophila melanogaster (Fruit fly) TR33459_c0_g1_i2 O18330 MRJP1_APIME 6.00E-18 GO:0048650; GO:0050829; GO:0050830; GO:0050832; GO:0005576; GO:0031640 "caste determination, influence by environmental factors; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; defense response to fungus; extracellular region; killing of cells of other organism" IPR011042; IPR017996; IPR003534; Major royal jelly protein 1 (MRJP-1) (56-kDa protein 4) (p56kP-4) (Bee-milk protein) (Royalactin) [Cleaved into: Jellein-1 (Jelleine-I); Jellein-2 (Jelleine-II); Jellein-4 (Jelleine-IV)] MRJP1 Apis mellifera (Honeybee) TR33460_c1_g1_i1 Q9JHG0 CBLN3_MOUSE 2.00E-09 GO:0005794; GO:0030054; GO:0005783; GO:0005615; GO:0045202 Golgi apparatus; cell junction; endoplasmic reticulum; extracellular space; synapse IPR001073; IPR008983; Cerebellin-3 Cbln3 Mus musculus (Mouse) TR33460_c1_g1_i2 P14417 APOA_MACMU 2.00E-14 GO:0006869; GO:0006508; GO:0004252 lipid transport; proteolysis; serine-type endopeptidase activity IPR000001; IPR013806; IPR018056; IPR001254; IPR001314; IPR009003; Apolipoprotein(a) (Apo(a)) (Lp(a)) (EC 3.4.21.-) (Fragment) LPA Macaca mulatta (Rhesus macaque) TR33460_c1_g1_i3 P06868 PLMN_BOVIN 2.00E-20 GO:0007596; GO:0005576; GO:0042730; GO:0006508; GO:0004252; GO:0048771 blood coagulation; extracellular region; fibrinolysis; proteolysis; serine-type endopeptidase activity; tissue remodeling IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Bos taurus (Bovine) TR33460_c1_g1_i4 P26928 HGFL_MOUSE 9.00E-11 GO:0007566; GO:0005576; GO:0006508; GO:0004252 embryo implantation; extracellular region; proteolysis; serine-type endopeptidase activity IPR024174; IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR001254; IPR001314; IPR009003; Hepatocyte growth factor-like protein (Macrophage stimulatory protein) (MSP) [Cleaved into: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain] Mst1 Hgfl Mus musculus (Mouse) TR33460_c1_g1_i5 Q7M323 PLMN_CAPHI 1.00E-14 GO:0007596; GO:0005576; GO:0042730; GO:0006508; GO:0008236; GO:0048771 blood coagulation; extracellular region; fibrinolysis; proteolysis; serine-type peptidase activity; tissue remodeling IPR000001; IPR013806; IPR018056; Plasminogen (EC 3.4.21.7) (Fragment) PLG Capra hircus (Goat) TR33462_c0_g1_i1 Q6IFT6 ANO7_RAT 1.00E-16 GO:0005254; GO:0005783; GO:0016021; GO:0005634; GO:0005886 chloride channel activity; endoplasmic reticulum; integral to membrane; nucleus; plasma membrane IPR007632; Anoctamin-7 (New gene expressed in prostate homolog) (Transmembrane protein 16G) Ano7 Ngep Tmem16g Rattus norvegicus (Rat) TR33462_c0_g1_i3 Q9BYT9 ANO3_HUMAN 1.00E-11 GO:0016021; GO:0034220; GO:0005886 integral to membrane; ion transmembrane transport; plasma membrane IPR007632; Anoctamin-3 (Transmembrane protein 16C) ANO3 C11orf25 TMEM16C GENX-3947 Homo sapiens (Human) TR33462_c1_g1_i1 Q9ER88 RT29_MOUSE 4.00E-76 GO:0008637; GO:0005759; GO:0005761; GO:0015935 apoptotic mitochondrial changes; mitochondrial matrix; mitochondrial ribosome; small ribosomal subunit IPR019368; IPR008092; "28S ribosomal protein S29, mitochondrial (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3)" Dap3 Mrps29 Mus musculus (Mouse) TR33462_c2_g1_i2 Q5JRC9 FA47A_HUMAN 1.00E-11 IPR026083; Protein FAM47A FAM47A Homo sapiens (Human) TR33462_c3_g1_i4 Q6KAR6 EXOC3_MOUSE 0 GO:0000145; GO:0006887; GO:0015031; GO:0030667 exocyst; exocytosis; protein transport; secretory granule membrane IPR010326; Exocyst complex component 3 (Exocyst complex component Sec6) Exoc3 Sec6l1 Mus musculus (Mouse) TR33462_c3_g1_i5 O60645 EXOC3_HUMAN 0 GO:0044267; GO:0000145; GO:0006887; GO:0015031; GO:0030667 cellular protein metabolic process; exocyst; exocytosis; protein transport; secretory granule membrane IPR010326; Exocyst complex component 3 (Exocyst complex component Sec6) EXOC3 SEC6 SEC6L1 Homo sapiens (Human) TR33462_c3_g1_i7 Q0V8C2 EXOC3_BOVIN 0 GO:0000145; GO:0006887; GO:0015031 exocyst; exocytosis; protein transport IPR010326; Exocyst complex component 3 (Exocyst complex component Sec6) EXOC3 SEC6 Bos taurus (Bovine) TR33462_c4_g1_i1 Q6IWH7 ANO7_HUMAN 8.00E-30 GO:0030054; GO:0005254; GO:0005829; GO:0005783; GO:0016021; GO:0034220; GO:0005634; GO:0005886 cell junction; chloride channel activity; cytosol; endoplasmic reticulum; integral to membrane; ion transmembrane transport; nucleus; plasma membrane IPR007632; Anoctamin-7 (Dresden transmembrane protein of the prostate) (D-TMPP) (IPCA-5) (New gene expressed in prostate) (Prostate cancer-associated protein 5) (Transmembrane protein 16G) ANO7 NGEP PCANAP5 TMEM16G Homo sapiens (Human) TR33462_c5_g1_i1 A8WQH2 PXDN_CAEBR 4.00E-10 GO:0005576; GO:0020037; GO:0042744; GO:0046872; GO:0004601 extracellular region; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Peroxidasin homolog (EC 1.11.1.7) pxn-1 CBG01526 Caenorhabditis briggsae TR33462_c6_g1_i1 Q6IWH7 ANO7_HUMAN 3.00E-22 GO:0030054; GO:0005254; GO:0005829; GO:0005783; GO:0016021; GO:0034220; GO:0005634; GO:0005886 cell junction; chloride channel activity; cytosol; endoplasmic reticulum; integral to membrane; ion transmembrane transport; nucleus; plasma membrane IPR007632; Anoctamin-7 (Dresden transmembrane protein of the prostate) (D-TMPP) (IPCA-5) (New gene expressed in prostate) (Prostate cancer-associated protein 5) (Transmembrane protein 16G) ANO7 NGEP PCANAP5 TMEM16G Homo sapiens (Human) TR33464_c2_g1_i1 A7RNG8 CCD22_NEMVE 0 IPR008530; Coiled-coil domain-containing protein 22 homolog v1g180167 Nematostella vectensis (Starlet sea anemone) TR33465_c0_g1_i1 Q13823 NOG2_HUMAN 0 GO:0005525; GO:0003924; GO:0005730; GO:0042254 GTP binding; GTPase activity; nucleolus; ribosome biogenesis IPR023179; IPR006073; IPR024929; IPR012971; IPR027417; Nucleolar GTP-binding protein 2 (Autoantigen NGP-1) GNL2 NGP1 Homo sapiens (Human) TR33465_c0_g1_i2 Q6C036 NOG2_YARLI 2.00E-179 GO:0005525; GO:0005730; GO:0042254 GTP binding; nucleolus; ribosome biogenesis IPR023179; IPR006073; IPR024929; IPR012971; IPR027417; Nucleolar GTP-binding protein 2 NOG2 YALI0F28083g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR33465_c0_g1_i4 Q99LH1 NOG2_MOUSE 3.00E-23 GO:0005525; GO:0003924; GO:0005730; GO:0042254 GTP binding; GTPase activity; nucleolus; ribosome biogenesis IPR023179; IPR006073; IPR024929; IPR012971; IPR027417; Nucleolar GTP-binding protein 2 Gnl2 Mus musculus (Mouse) TR33471_c0_g1_i2 Q08EJ0 PL8L1_MOUSE 7.00E-13 IPR006461; PLAC8-like protein 1 Plac8l1 Mus musculus (Mouse) TR33473_c0_g2_i1 P70627 FOLH1_RAT 3.00E-171 GO:0004180; GO:0016805; GO:0016021; GO:0046872; GO:0008237; GO:0005886; GO:0006508 carboxypeptidase activity; dipeptidase activity; integral to membrane; metal ion binding; metallopeptidase activity; plasma membrane; proteolysis IPR007484; IPR003137; IPR007365; Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Folate hydrolase 1) (Folylpoly-gamma-glutamate carboxypeptidase) (FGCP) (Glutamate carboxypeptidase II) (GCPII) (Membrane glutamate carboxypeptidase) (mGCP) (N-acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Prostate-specific membrane antigen homolog) (Pteroylpoly-gamma-glutamate carboxypeptidase) Folh1 Naalad1 Rattus norvegicus (Rat) TR33473_c0_g2_i2 B2GUY2 TFR2_RAT 2.00E-49 GO:0016021; GO:0008233; GO:0005886; GO:0006508 integral to membrane; peptidase activity; plasma membrane; proteolysis IPR007484; IPR003137; IPR007365; Transferrin receptor protein 2 (TfR2) Tfr2 Trfr2 Rattus norvegicus (Rat) TR33474_c1_g1_i1 Q869T9 EKIA_DICDI 2.00E-27 GO:0005524; GO:0005737; GO:0004305; GO:0006646 ATP binding; cytoplasm; ethanolamine kinase activity; phosphatidylethanolamine biosynthetic process IPR011009; Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3. Probable ethanolamine kinase A (EC 2.7.1.82) etnkA DDB_G0274955 Dictyostelium discoideum (Slime mold) TR33474_c1_g1_i3 O55229 CHKB_MOUSE 2.00E-63 GO:0005524; GO:0004103; GO:0004305; GO:0007517; GO:0006646 ATP binding; choline kinase activity; ethanolamine kinase activity; muscle organ development; phosphatidylethanolamine biosynthetic process IPR011009; Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3. Choline/ethanolamine kinase (Choline kinase beta) (CK) (CKB) (EC 2.7.1.32) (Ethanolamine kinase) (EK) (EC 2.7.1.82) (choline/ethanolamine kinase beta) (CKEKB) Chkb Chetk Chkl Mus musculus (Mouse) TR33475_c1_g1_i1 P41932 14331_CAEEL 2.00E-107 GO:0045167; GO:0005938; GO:0001708; GO:0000132; GO:0030590; GO:0007126; GO:0005634; GO:0009949; GO:0035046; GO:0007346; GO:0010070 G5EC23; Q11184; Q10666; Q21921 asymmetric protein localization involved in cell fate determination; cell cortex; cell fate specification; establishment of mitotic spindle orientation; first cell cycle pseudocleavage; meiosis; nucleus; polarity specification of anterior/posterior axis; pronuclear migration; regulation of mitotic cell cycle; zygote asymmetric cell division IPR000308; IPR023409; IPR023410; 14-3-3-like protein 1 (Partitioning defective protein 5) par-5 ftt-1 M117.2 Caenorhabditis elegans TR33476_c0_g1_i1 Q96RK4 BBS4_HUMAN 0 GO:0034464; GO:0030534; GO:0043014; GO:0048487; GO:0048854; GO:0034451; GO:0005814; GO:0051297; GO:0021987; GO:0060170; GO:0060027; GO:0000910; GO:0016358; GO:0034452; GO:0045444; GO:0001947; GO:0021766; GO:0046907; GO:0051457; GO:0032402; GO:0034454; GO:0005932; GO:0003777; GO:0038108; GO:0010629; GO:0003085; GO:0001843; GO:0031513; GO:0035058; GO:0000242; GO:0045494; GO:0051877; GO:0045724; GO:0040018; GO:0060296; GO:0032465; GO:0019216; GO:0046548; GO:0007608; GO:0050893; GO:0007286; GO:0021756; GO:0007601 P05062; A8MTZ0; Q8NFJ9; Q14203; Q99814; Q15154 BBSome; adult behavior; alpha-tubulin binding; beta-tubulin binding; brain morphogenesis; centriolar satellite; centriole; centrosome organization; cerebral cortex development; cilium membrane; convergent extension involved in gastrulation; cytokinesis; dendrite development; dynactin binding; fat cell differentiation; heart looping; hippocampus development; intracellular transport; maintenance of protein location in nucleus; melanosome transport; microtubule anchoring at centrosome; microtubule basal body; microtubule motor activity; negative regulation of appetite by leptin-mediated signaling pathway; negative regulation of gene expression; negative regulation of systemic arterial blood pressure; neural tube closure; nonmotile primary cilium; nonmotile primary cilium assembly; pericentriolar material; photoreceptor cell maintenance; pigment granule aggregation in cell center; positive regulation of cilium assembly; positive regulation of multicellular organism growth; regulation of cilium beat frequency involved in ciliary motility; regulation of cytokinesis; regulation of lipid metabolic process; retinal rod cell development; sensory perception of smell; sensory processing; spermatid development; striatum development; visual perception IPR013026; IPR011990; IPR019734; Bardet-Biedl syndrome 4 protein BBS4 Homo sapiens (Human) TR33478_c4_g1_i1 Q9DAM5 TPC_MOUSE 1.00E-07 GO:0016021; GO:0005743; GO:0005739; GO:0055085 integral to membrane; mitochondrial inner membrane; mitochondrion; transmembrane transport IPR002067; IPR018108; IPR023395; Mitochondrial thiamine pyrophosphate carrier (Solute carrier family 25 member 19) Slc25a19 Mus musculus (Mouse) TR33478_c4_g1_i2 Q96H78 S2544_HUMAN 6.00E-55 GO:0016021; GO:0005743; GO:0055085 integral to membrane; mitochondrial inner membrane; transmembrane transport IPR002067; IPR018108; IPR023395; Solute carrier family 25 member 44 SLC25A44 KIAA0446 Homo sapiens (Human) TR33479_c0_g1_i3 P02642 TNNT2_CHICK 5.00E-10 GO:0006937; GO:0005861 regulation of muscle contraction; troponin complex IPR027707; IPR001978; "Troponin T, cardiac muscle isoforms (TnTC)" TNNT2 Gallus gallus (Chicken) TR33479_c0_g1_i4 P19351 TNNT_DROME 2.00E-26 GO:0005509; GO:0006874; GO:0007498; GO:0007005; GO:0046716; GO:0048644; GO:0006937; GO:0045214; GO:0030240; GO:0005865; GO:0005861 calcium ion binding; cellular calcium ion homeostasis; mesoderm development; mitochondrion organization; muscle cell cellular homeostasis; muscle organ morphogenesis; regulation of muscle contraction; sarcomere organization; skeletal muscle thin filament assembly; striated muscle thin filament; troponin complex IPR027707; IPR001978; "Troponin T, skeletal muscle (Protein intended thorax) (Protein upheld)" up int CG7107 Drosophila melanogaster (Fruit fly) TR33479_c0_g1_i6 P19351 TNNT_DROME 3.00E-26 GO:0005509; GO:0006874; GO:0007498; GO:0007005; GO:0046716; GO:0048644; GO:0006937; GO:0045214; GO:0030240; GO:0005865; GO:0005861 calcium ion binding; cellular calcium ion homeostasis; mesoderm development; mitochondrion organization; muscle cell cellular homeostasis; muscle organ morphogenesis; regulation of muscle contraction; sarcomere organization; skeletal muscle thin filament assembly; striated muscle thin filament; troponin complex IPR027707; IPR001978; "Troponin T, skeletal muscle (Protein intended thorax) (Protein upheld)" up int CG7107 Drosophila melanogaster (Fruit fly) TR3348_c0_g1_i1 P04323 POL3_DROME 1.00E-06 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR33484_c4_g1_i1 Q6P3Z3 THAP4_MOUSE 1.00E-46 GO:0003677; GO:0046872 DNA binding; metal ion binding IPR011038; IPR014878; IPR006612; THAP domain-containing protein 4 Thap4 Mus musculus (Mouse) TR33485_c0_g1_i1 D2GXS7 TRIM2_AILME 3.00E-13 GO:0005737; GO:0043523; GO:0004842; GO:0008270 cytoplasm; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) TR33487_c3_g1_i1 O95243 MBD4_HUMAN 3.00E-68 GO:0031572; GO:0000785; GO:0005737; GO:0045008; GO:0004520; GO:0008630; GO:0005654; GO:0008263; GO:0009314; GO:0003696 Q13158 G2 DNA damage checkpoint; chromatin; cytoplasm; depyrimidination; endodeoxyribonuclease activity; intrinsic apoptotic signaling pathway in response to DNA damage; nucleoplasm; pyrimidine-specific mismatch base pair DNA N-glycosylase activity; response to radiation; satellite DNA binding IPR016177; IPR011257; IPR003265; IPR017352; IPR001739; Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase) MBD4 MED1 Homo sapiens (Human) TR33487_c6_g1_i1 Q00566 MECP2_RAT 2.00E-20 GO:0031490; GO:0005829; GO:0010385; GO:0000400; GO:0008327; GO:0000122; GO:0000790; GO:0043234; GO:0006351; GO:0045322 "chromatin DNA binding; cytosol; double-stranded methylated DNA binding; four-way junction DNA binding; methyl-CpG binding; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; protein complex; transcription, DNA-dependent; unmethylated CpG binding" IPR017956; IPR016177; IPR017353; IPR001739; Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) Mecp2 Rattus norvegicus (Rat) TR33488_c0_g1_i1 B7P877 NCBP2_IXOSC 1.00E-32 GO:0006370; GO:0000339; GO:0031047; GO:0045292; GO:0005846; GO:0000166; GO:0005634 "7-methylguanosine mRNA capping; RNA cap binding; gene silencing by RNA; mRNA cis splicing, via spliceosome; nuclear cap binding complex; nucleotide binding; nucleus" IPR027157; IPR012677; IPR000504; Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (NCBP 20 kDa subunit) (CBP20) Cbp20 ISCW017479 Ixodes scapularis (Black-legged tick) (Deer tick) TR33488_c0_g2_i1 B7P877 NCBP2_IXOSC 2.00E-83 GO:0006370; GO:0000339; GO:0031047; GO:0045292; GO:0005846; GO:0000166; GO:0005634 "7-methylguanosine mRNA capping; RNA cap binding; gene silencing by RNA; mRNA cis splicing, via spliceosome; nuclear cap binding complex; nucleotide binding; nucleus" IPR027157; IPR012677; IPR000504; Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (NCBP 20 kDa subunit) (CBP20) Cbp20 ISCW017479 Ixodes scapularis (Black-legged tick) (Deer tick) TR33489_c1_g2_i2 Q9NX58 LYAR_HUMAN 3.00E-42 GO:0046872; GO:0005730 metal ion binding; nucleolus IPR014898; Cell growth-regulating nucleolar protein LYAR PNAS-5 Homo sapiens (Human) TR33490_c0_g1_i1 Q8N5U0 CK042_HUMAN 5.00E-06 Uncharacterized protein C11orf42 C11orf42 Homo sapiens (Human) TR33491_c0_g1_i3 Q96ER9 CCD51_HUMAN 1.00E-13 GO:0016021; GO:0005739; GO:0005634 integral to membrane; mitochondrion; nucleus Coiled-coil domain-containing protein 51 CCDC51 Homo sapiens (Human) TR33493_c0_g1_i1 Q3SZV6 TIM21_BOVIN 3.00E-35 GO:0016021; GO:0005744; GO:0032981; GO:0033617; GO:0030150 integral to membrane; mitochondrial inner membrane presequence translocase complex; mitochondrial respiratory chain complex I assembly; mitochondrial respiratory chain complex IV assembly; protein import into mitochondrial matrix IPR013261; "Mitochondrial import inner membrane translocase subunit Tim21 (TIM21-like protein, mitochondrial)" TIMM21 TIM21 Bos taurus (Bovine) TR33493_c0_g1_i2 Q5XKA2 TIM21_XENLA 3.00E-37 GO:0016021; GO:0005744; GO:0030150 integral to membrane; mitochondrial inner membrane presequence translocase complex; protein import into mitochondrial matrix IPR013261; "Mitochondrial import inner membrane translocase subunit Tim21 (TIM21-like protein, mitochondrial)" timm21 tim21 Xenopus laevis (African clawed frog) TR33494_c0_g4_i1 O18883 TXND9_BOVIN 6.00E-86 GO:0045454 cell redox homeostasis IPR012336; IPR013766; Thioredoxin domain-containing protein 9 (Protein 1-4) TXNDC9 APACD Bos taurus (Bovine) TR33495_c3_g1_i1 Q9TWL9 COMA_CONMA 3.00E-07 GO:0005576; GO:0016042; GO:0004623 extracellular region; lipid catabolic process; phospholipase A2 activity IPR016090; Conodipine-M alpha chain (PLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) Conus magus (Magus cone) (Magician's cone snail) TR33495_c4_g1_i1 Q3SX11 NSA2_BOVIN 1.00E-157 GO:0005730; GO:0006364; GO:0030529 nucleolus; rRNA processing; ribonucleoprotein complex IPR022309; Ribosome biogenesis protein NSA2 homolog (TGF-beta-inducible nuclear protein 1) NSA2 TINP1 Bos taurus (Bovine) TR33497_c0_g1_i2 Q5UR67 YR617_MIMIV 1.00E-28 IPR012816; Uncharacterized protein R617 MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) TR33500_c1_g1_i1 Q92990 GLMN_HUMAN 7.00E-40 GO:0031462; GO:0031463; GO:0031464; GO:0042692; GO:0042130; GO:0001843; GO:0050715; GO:0045086; GO:0042327; GO:0040029; GO:0032434; GO:0031625; GO:0055105; GO:0001570 "Cul2-RING ubiquitin ligase complex; Cul3-RING ubiquitin ligase complex; Cul4A-RING ubiquitin ligase complex; muscle cell differentiation; negative regulation of T cell proliferation; neural tube closure; positive regulation of cytokine secretion; positive regulation of interleukin-2 biosynthetic process; positive regulation of phosphorylation; regulation of gene expression, epigenetic; regulation of proteasomal ubiquitin-dependent protein catabolic process; ubiquitin protein ligase binding; ubiquitin-protein ligase inhibitor activity; vasculogenesis" IPR019516; IPR013877; Glomulin (FK506-binding protein-associated protein) (FAP) (FKBP-associated protein) GLMN FAP48 FAP68 VMGLOM Homo sapiens (Human) TR33501_c6_g1_i1 O94967 WDR47_HUMAN 4.00E-110 GO:0005737; GO:0005874; GO:0007275 cytoplasm; microtubule; multicellular organismal development IPR006595; IPR006594; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 47 (Neuronal enriched MAP interacting protein) (Nemitin) WDR47 KIAA0893 Homo sapiens (Human) TR33503_c1_g1_i1 Q5XGI5 WDR83_XENTR 1.00E-133 GO:0005737 cytoplasm IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat domain-containing protein 83 (Mitogen-activated protein kinase organizer 1) (MAPK organizer 1) wdr83 morg1 TGas070i04.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33506_c1_g1_i1 Q5PQQ9 CEP70_RAT 1.00E-31 GO:0005813; GO:0005737; GO:0031965 centrosome; cytoplasm; nuclear membrane Centrosomal protein of 70 kDa (Cep70) Cep70 Rattus norvegicus (Rat) TR33508_c5_g1_i1 Q5IS99 CASP3_SAIBB 4.00E-14 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Saimiri boliviensis boliviensis (Bolivian squirrel monkey) TR33508_c5_g1_i3 Q2PFV2 CASP3_MACFA 5.00E-28 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 QmoA-14231 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR33511_c1_g1_i3 Q95SX7 RTBS_DROME 4.00E-07 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR33514_c0_g1_i1 Q9CZJ2 HS12B_MOUSE 1.00E-89 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR33515_c0_g3_i2 Q1T7B8 CENPO_CHICK 4.00E-09 GO:0034508; GO:0000776; GO:0005634 centromere complex assembly; kinetochore; nucleus IPR018464; Centromere protein O (CENP-O) CENPO RCJMB04_17f21 Gallus gallus (Chicken) TR33516_c3_g2_i1 Q8K3J1 NDUS8_MOUSE 3.00E-86 GO:0051539; GO:0008137; GO:0046872; GO:0005747; GO:0032981; GO:0005739; GO:0006979 "4 iron, 4 sulfur cluster binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; mitochondrial respiratory chain complex I; mitochondrial respiratory chain complex I assembly; mitochondrion; response to oxidative stress" IPR001450; IPR017896; IPR017900; IPR010226; "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-23kD) (CI-23kD) (NADH-ubiquinone oxidoreductase 23 kDa subunit)" Ndufs8 Mus musculus (Mouse) TR33516_c3_g2_i2 Q8K3J1 NDUS8_MOUSE 5.00E-85 GO:0051539; GO:0008137; GO:0046872; GO:0005747; GO:0032981; GO:0005739; GO:0006979 "4 iron, 4 sulfur cluster binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; mitochondrial respiratory chain complex I; mitochondrial respiratory chain complex I assembly; mitochondrion; response to oxidative stress" IPR001450; IPR017896; IPR017900; IPR010226; "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-23kD) (CI-23kD) (NADH-ubiquinone oxidoreductase 23 kDa subunit)" Ndufs8 Mus musculus (Mouse) TR33516_c4_g1_i1 Q6GM44 MARH5_XENLA 8.00E-118 GO:0005783; GO:0016021; GO:0005741; GO:0090344; GO:0051865; GO:0090140; GO:0004842; GO:0008270 endoplasmic reticulum; integral to membrane; mitochondrial outer membrane; negative regulation of cell aging; protein autoubiquitination; regulation of mitochondrial fission; ubiquitin-protein ligase activity; zinc ion binding IPR011016; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MARCH5 (EC 6.3.2.-) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) 5-Mar Xenopus laevis (African clawed frog) TR33518_c0_g1_i1 B3H615 ING2_ARATH 1.00E-19 GO:0016568; GO:0035064; GO:0005634; GO:0040008; GO:0006355; GO:0006351; GO:0008270 "chromatin modification; methylated histone residue binding; nucleus; regulation of growth; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR024610; IPR011011; IPR001965; IPR019787; IPR013083; PHD finger protein ING2 (Protein INHIBITOR OF GROWTH 2) (Protein AtING2) ING2 At1g54390 F20D21.22 Arabidopsis thaliana (Mouse-ear cress) TR33518_c0_g1_i2 Q9UNL4 ING4_HUMAN 9.00E-100 GO:0006978; GO:0006260; GO:0006915; GO:0007050; GO:0043966; GO:0043983; GO:0043981; GO:0043982; GO:0000123; GO:0035064; GO:0008285; GO:0045926; GO:0045892; GO:0043065; GO:0003713; GO:0008270 P68431; Q14103; Q14103-4 "DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA replication; apoptotic process; cell cycle arrest; histone H3 acetylation; histone H4-K12 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase complex; methylated histone residue binding; negative regulation of cell proliferation; negative regulation of growth; negative regulation of transcription, DNA-dependent; positive regulation of apoptotic process; transcription coactivator activity; zinc ion binding" IPR024610; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Inhibitor of growth protein 4 (p29ING4) ING4 My036 Homo sapiens (Human) TR33518_c0_g1_i3 Q9H160 ING2_HUMAN 9.00E-29 GO:0016602; GO:0003677; GO:0016580; GO:0003682; GO:0016568; GO:0048133; GO:0007141; GO:0035064; GO:0043066; GO:1902166; GO:0035091; GO:0045893; GO:0030511; GO:0032403; GO:2000772; GO:0040008; GO:0072520; GO:0007165; GO:0030317; GO:0007286; GO:0006351; GO:0008270 P12004; Q9HCE7 "CCAAT-binding factor complex; DNA binding; Sin3 complex; chromatin binding; chromatin modification; male germ-line stem cell division; male meiosis I; methylated histone residue binding; negative regulation of apoptotic process; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; phosphatidylinositol binding; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; protein complex binding; regulation of cellular senescence; regulation of growth; seminiferous tubule development; signal transduction; sperm motility; spermatid development; transcription, DNA-dependent; zinc ion binding" IPR024610; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Inhibitor of growth protein 2 (Inhibitor of growth 1-like protein) (ING1Lp) (p32) (p33ING2) ING2 ING1L Homo sapiens (Human) TR33520_c4_g1_i1 P70388 RAD50_MOUSE 1.00E-107 GO:0005524; GO:0006281; GO:0030870; GO:0000781; GO:0007126; GO:0004518; GO:0090305; GO:0045120; GO:0006974; GO:0008270 "ATP binding; DNA repair; Mre11 complex; chromosome, telomeric region; meiosis; nuclease activity; nucleic acid phosphodiester bond hydrolysis; pronucleus; response to DNA damage stimulus; zinc ion binding" IPR027417; IPR004584; IPR007517; IPR013134; DNA repair protein RAD50 (mRad50) (EC 3.6.-.-) Rad50 Mus musculus (Mouse) TR33520_c4_g1_i2 Q8TXI4 RAD50_METKA 1.00E-08 GO:0005524; GO:0006200; GO:0016887; GO:0006302; GO:0004519; GO:0004527; GO:0090305; GO:0008270 ATP binding; ATP catabolic process; ATPase activity; double-strand break repair; endonuclease activity; exonuclease activity; nucleic acid phosphodiester bond hydrolysis; zinc ion binding IPR003593; IPR027417; IPR009053; IPR022982; IPR007517; IPR003395; IPR018159; IPR013134; DNA double-strand break repair Rad50 ATPase rad50 sbcC MK0690 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) TR33520_c4_g1_i3 P70388 RAD50_MOUSE 9.00E-91 GO:0005524; GO:0006281; GO:0030870; GO:0000781; GO:0007126; GO:0004518; GO:0090305; GO:0045120; GO:0006974; GO:0008270 "ATP binding; DNA repair; Mre11 complex; chromosome, telomeric region; meiosis; nuclease activity; nucleic acid phosphodiester bond hydrolysis; pronucleus; response to DNA damage stimulus; zinc ion binding" IPR027417; IPR004584; IPR007517; IPR013134; DNA repair protein RAD50 (mRad50) (EC 3.6.-.-) Rad50 Mus musculus (Mouse) TR33523_c1_g1_i1 Q8K3L6 GIMA5_RAT 8.00E-26 GO:0005525; GO:0030217; GO:0043029; GO:0016021; GO:0005764; GO:0005741; GO:0005739; GO:0043011; GO:0050868; GO:0043066; GO:0032689; GO:0050995; GO:0045019; GO:0032831; GO:0010524; GO:0045588; GO:0002925; GO:0045838; GO:0002729; GO:0045954; GO:0046902; GO:0001659 "GTP binding; T cell differentiation; T cell homeostasis; integral to membrane; lysosome; mitochondrial outer membrane; mitochondrion; myeloid dendritic cell differentiation; negative regulation of T cell activation; negative regulation of apoptotic process; negative regulation of interferon-gamma production; negative regulation of lipid catabolic process; negative regulation of nitric oxide biosynthetic process; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of calcium ion transport into cytosol; positive regulation of gamma-delta T cell differentiation; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of membrane potential; positive regulation of natural killer cell cytokine production; positive regulation of natural killer cell mediated cytotoxicity; regulation of mitochondrial membrane permeability; temperature homeostasis" IPR006703; IPR027417; GTPase IMAP family member 5 (Immunity-associated nucleotide 4 protein) (IAN-4) (Immunity-associated nucleotide 4-like 1 protein) Gimap5 Ian4 Ian4l1 Iddm1 Lyp Rattus norvegicus (Rat) TR33523_c1_g1_i2 Q8NHV1 GIMA7_HUMAN 2.00E-39 GO:0005525; GO:0003924; GO:0005811 GTP binding; GTPase activity; lipid particle IPR006703; IPR027417; GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) TR33524_c0_g1_i1 P28024 PSB4_XENLA 1.00E-110 GO:0005737; GO:0005634; GO:0005839; GO:0051603; GO:0004298 cytoplasm; nucleus; proteasome core complex; proteolysis involved in cellular protein catabolic process; threonine-type endopeptidase activity IPR016050; IPR016295; IPR001353; IPR023333; Proteasome subunit beta type-4 (EC 3.4.25.1) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (Fragment) psmb4 Xenopus laevis (African clawed frog) TR33525_c4_g1_i1 P20794 MAK_HUMAN 9.00E-95 GO:0005524; GO:0030154; GO:0005813; GO:0004693; GO:0005737; GO:0030496; GO:0072686; GO:0007275; GO:0005634; GO:0045494; GO:0001917; GO:0001750; GO:0046777; GO:0004672; GO:0006355; GO:0007283; GO:0003713; GO:0006351 P10275; Q9UM11 "ATP binding; cell differentiation; centrosome; cyclin-dependent protein serine/threonine kinase activity; cytoplasm; midbody; mitotic spindle; multicellular organismal development; nucleus; photoreceptor cell maintenance; photoreceptor inner segment; photoreceptor outer segment; protein autophosphorylation; protein kinase activity; regulation of transcription, DNA-dependent; spermatogenesis; transcription coactivator activity; transcription, DNA-dependent" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell-associated kinase) MAK Homo sapiens (Human) TR33525_c4_g2_i1 Q04859 MAK_MOUSE 1.00E-69 GO:0005524; GO:0005813; GO:0004693; GO:0005737; GO:0030496; GO:0072686; GO:0005634; GO:0045494; GO:0001917; GO:0001750; GO:0046777; GO:0006355; GO:0003713; GO:0006351 "ATP binding; centrosome; cyclin-dependent protein serine/threonine kinase activity; cytoplasm; midbody; mitotic spindle; nucleus; photoreceptor cell maintenance; photoreceptor inner segment; photoreceptor outer segment; protein autophosphorylation; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell-associated kinase) (Protein kinase RCK) Mak Rck Mus musculus (Mouse) TR33526_c0_g1_i2 Q2T9T0 PPR32_BOVIN 6.00E-68 GO:0019902 phosphatase binding Protein phosphatase 1 regulatory subunit 32 PPP1R32 Bos taurus (Bovine) TR33529_c1_g1_i2 Q2TBS2 RM21_BOVIN 8.00E-30 GO:0005739; GO:0005840 mitochondrion; ribosome "39S ribosomal protein L21, mitochondrial (L21mt) (MRP-L21)" MRPL21 Bos taurus (Bovine) TR33532_c0_g1_i1 Q7ZVN7 MED15_DANRE 3.00E-78 GO:0001104; GO:0005737; GO:0016592 RNA polymerase II transcription cofactor activity; cytoplasm; mediator complex IPR019087; Mediator of RNA polymerase II transcription subunit 15 (Mediator complex subunit 15) med15 pcqap zgc:55839 Danio rerio (Zebrafish) (Brachydanio rerio) TR33533_c5_g3_i1 A2VE15 FADS6_BOVIN 2.00E-50 GO:0006633; GO:0016021; GO:0016491 fatty acid biosynthetic process; integral to membrane; oxidoreductase activity IPR005804; Lipid metabolism; fatty acid metabolism. Fatty acid desaturase 6 (EC 1.14.19.-) FADS6 Bos taurus (Bovine) TR33533_c5_g4_i1 Q80UG1 FADS6_MOUSE 1.00E-42 GO:0006633; GO:0016021; GO:0016491 fatty acid biosynthetic process; integral to membrane; oxidoreductase activity IPR005804; Lipid metabolism; fatty acid metabolism. Fatty acid desaturase 6 (EC 1.14.19.-) Fads6 Mus musculus (Mouse) TR33535_c1_g1_i1 Q9NRA2 S17A5_HUMAN 5.00E-50 GO:0006865; GO:0030054; GO:0005887; GO:0005765; GO:0015136; GO:0015739; GO:0005351; GO:0030672 amino acid transport; cell junction; integral to plasma membrane; lysosomal membrane; sialic acid transmembrane transporter activity; sialic acid transport; sugar:hydrogen symporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) TR33535_c1_g1_i3 O82390 ANTR1_ARATH 4.00E-28 GO:0009535; GO:0030504; GO:0005315; GO:0016021; GO:0009416; GO:0009624; GO:0006814; GO:0015293 chloroplast thylakoid membrane; inorganic diphosphate transmembrane transporter activity; inorganic phosphate transmembrane transporter activity; integral to membrane; response to light stimulus; response to nematode; sodium ion transport; symporter activity IPR011701; IPR020846; IPR016196; "Sodium-dependent phosphate transport protein 1, chloroplastic (Anion transporter 1) (Na(+)/PI cotransporter 1) (Phosphate transporter PHT4;1) (Sodium/phosphate cotransporter 1)" ANTR1 PHT4;1 At2g29650 T27A16.25 Arabidopsis thaliana (Mouse-ear cress) TR33535_c3_g1_i2 Q9NRA2 S17A5_HUMAN 6.00E-93 GO:0006865; GO:0030054; GO:0005887; GO:0005765; GO:0015136; GO:0015739; GO:0005351; GO:0030672 amino acid transport; cell junction; integral to plasma membrane; lysosomal membrane; sialic acid transmembrane transporter activity; sialic acid transport; sugar:hydrogen symporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) TR33536_c1_g1_i1 Q9UPM9 B9D1_HUMAN 6.00E-83 GO:0036038; GO:0043010; GO:0035051; GO:0005813; GO:0042384; GO:0035085; GO:0042733; GO:0008158; GO:0001701; GO:0016020; GO:0005932; GO:0060563; GO:0032880; GO:0007224 TCTN-B9D complex; camera-type eye development; cardiocyte differentiation; centrosome; cilium assembly; cilium axoneme; embryonic digit morphogenesis; hedgehog receptor activity; in utero embryonic development; membrane; microtubule basal body; neuroepithelial cell differentiation; regulation of protein localization; smoothened signaling pathway IPR010796; B9 domain-containing protein 1 (MKS1-related protein 1) B9D1 MKSR1 Homo sapiens (Human) TR33536_c3_g1_i1 Q47898 ASPG_ELIMR 4.00E-38 GO:0003948; GO:0008233; GO:0042597; GO:0006508 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity; peptidase activity; periplasmic space; proteolysis IPR000246; IPR019546; N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (AGA) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain] Elizabethkingia miricola (Chryseobacterium miricola) TR33536_c3_g1_i2 Q5JHT1 ASGX_PYRKO 2.00E-24 GO:0004067; GO:0008233; GO:0006508 asparaginase activity; peptidase activity; proteolysis IPR000246; Putative L-asparaginase (EC 3.5.1.1) (L-asparagine amidohydrolase) [Cleaved into: Putative L-asparaginase subunit alpha; Putative L-asparaginase subunit beta] TK2246 Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) TR33536_c4_g2_i2 P08478 AMDA_XENLA 2.00E-139 GO:0005507; GO:0016021; GO:0006518; GO:0004598; GO:0004504; GO:0030658 copper ion binding; integral to membrane; peptide metabolic process; peptidylamidoglycolate lyase activity; peptidylglycine monooxygenase activity; transport vesicle membrane IPR011042; IPR014784; IPR020611; IPR014783; IPR000323; IPR001258; IPR013017; IPR000720; IPR008977; Peptidyl-glycine alpha-amidating monooxygenase A (PAM-A) (Peptide C-terminal alpha-amidating enzyme I) (AE-I) (Peptidyl-glycine alpha-amidating monooxygenase I) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase A (PHM-A) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase A (EC 4.3.2.5) (Peptidylamidoglycolate lyase-A) (PAL-A)] pam-a Xenopus laevis (African clawed frog) TR33537_c0_g1_i11 Q5R1W5 SRSF2_PANTR 1.00E-28 GO:0003723; GO:0008380; GO:0006397; GO:0016607; GO:0000166 RNA binding; RNA splicing; mRNA processing; nuclear speck; nucleotide binding IPR012677; IPR000504; "Serine/arginine-rich splicing factor 2 (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)" SRSF2 SFRS2 Pan troglodytes (Chimpanzee) TR33538_c4_g1_i4 Q7T339 CHMP5_DANRE 6.00E-81 GO:0005829; GO:0010008; GO:0015031 cytosol; endosome membrane; protein transport IPR005024; Charged multivesicular body protein 5 (Chromatin-modifying protein 5) chmp5 Danio rerio (Zebrafish) (Brachydanio rerio) TR33538_c4_g1_i5 Q7T339 CHMP5_DANRE 3.00E-82 GO:0005829; GO:0010008; GO:0015031 cytosol; endosome membrane; protein transport IPR005024; Charged multivesicular body protein 5 (Chromatin-modifying protein 5) chmp5 Danio rerio (Zebrafish) (Brachydanio rerio) TR33541_c0_g2_i3 O35900 LSM2_MOUSE 3.00E-57 GO:0003723; GO:0008380; GO:0006397; GO:0019901; GO:0005681 RNA binding; RNA splicing; mRNA processing; protein kinase binding; spliceosomal complex IPR010920; IPR001163; IPR006649; IPR016654; U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (snRNP core Sm-like protein Sm-x5) Lsm2 G7b Mus musculus (Mouse) TR33545_c0_g2_i1 A9JS71 ECHD3_XENLA 5.00E-123 GO:0003824; GO:0005739 catalytic activity; mitochondrion IPR001753; "Enoyl-CoA hydratase domain-containing protein 3, mitochondrial" echdc3 Xenopus laevis (African clawed frog) TR33546_c0_g1_i1 Q9CXP9 EXO5_MOUSE 3.00E-67 GO:0051539; GO:0003677; GO:0005829; GO:0036297; GO:0046872; GO:0005634; GO:0045145 "4 iron, 4 sulfur cluster binding; DNA binding; cytosol; interstrand cross-link repair; metal ion binding; nucleus; single-stranded DNA 5'-3' exodeoxyribonuclease activity" IPR019190; Exonuclease V (Exo V) (mExo5) (EC 3.1.-.-) (Defects in morphology protein 1 homolog) Exo5 Dem1 Mus musculus (Mouse) TR33547_c5_g2_i1 A4KWA6 CL2D3_RAT 3.00E-06 GO:0030246; GO:0016021; GO:0005886 carbohydrate binding; integral to membrane; plasma membrane IPR001304; IPR016186; IPR016187; C-type lectin domain family 2 member D3 Clec2d3 Rattus norvegicus (Rat) TR33547_c5_g2_i4 Q9UBG0 MRC2_HUMAN 3.00E-13 GO:0030246; GO:0006897; GO:0016021 carbohydrate binding; endocytosis; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; C-type mannose receptor 2 (C-type lectin domain family 13 member E) (Endocytic receptor 180) (Macrophage mannose receptor 2) (Urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (Urokinase receptor-associated protein) (CD antigen CD280) MRC2 CLEC13E ENDO180 KIAA0709 UPARAP Homo sapiens (Human) TR33547_c5_g2_i5 Q6ZS10 CL17A_HUMAN 5.00E-12 GO:0009986; GO:0042806; GO:0016021; GO:0005537; GO:0046872 cell surface; fucose binding; integral to membrane; mannose binding; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; "C-type lectin domain family 17, member A (Prolectin)" CLEC17A Homo sapiens (Human) TR33547_c5_g2_i6 P86854 PLCL_MYTGA 4.00E-19 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR33551_c0_g1_i2 O75506 HSBP1_HUMAN 3.00E-27 GO:0005856; GO:0006936; GO:0000122; GO:0005634; GO:0003714 cytoskeleton; muscle contraction; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription corepressor activity IPR009643; Heat shock factor-binding protein 1 (Nasopharyngeal carcinoma-associated antigen 13) (NPC-A-13) HSBP1 HSF1BP Homo sapiens (Human) TR33552_c1_g1_i1 A6QQ68 F228B_BOVIN 3.00E-20 Protein FAM228B FAM228B Bos taurus (Bovine) TR33553_c0_g1_i1 Q495B1 AKD1A_HUMAN 2.00E-12 GO:0007165 signal transduction IPR002110; IPR020683; IPR011029; IPR000488; Ankyrin repeat and death domain-containing protein 1A ANKDD1A Homo sapiens (Human) TR33553_c0_g1_i11 P57044 ILK_CAVPO 1.00E-10 GO:0005524; GO:0005925; GO:0030027; GO:0005886; GO:0030513; GO:0090263; GO:0045669; GO:0042327; GO:0045893; GO:0004674; GO:0030017 "ATP binding; focal adhesion; lamellipodium; plasma membrane; positive regulation of BMP signaling pathway; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of osteoblast differentiation; positive regulation of phosphorylation; positive regulation of transcription, DNA-dependent; protein serine/threonine kinase activity; sarcomere" IPR002110; IPR020683; IPR016253; IPR011009; IPR000719; IPR001245; Integrin-linked protein kinase (EC 2.7.11.1) (Beta-integrin-linked kinase) ILK Cavia porcellus (Guinea pig) TR33553_c0_g1_i2 Q9VCA8 ANKHM_DROME 7.00E-22 GO:0003723; GO:0019730; GO:0051298; GO:0001751; GO:0005811; GO:0043066; GO:0046427; GO:0007169 RNA binding; antimicrobial humoral response; centrosome duplication; compound eye photoreceptor cell differentiation; lipid particle; negative regulation of apoptotic process; positive regulation of JAK-STAT cascade; transmembrane receptor protein tyrosine kinase signaling pathway IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) TR33553_c0_g1_i3 P57044 ILK_CAVPO 1.00E-10 GO:0005524; GO:0005925; GO:0030027; GO:0005886; GO:0030513; GO:0090263; GO:0045669; GO:0042327; GO:0045893; GO:0004674; GO:0030017 "ATP binding; focal adhesion; lamellipodium; plasma membrane; positive regulation of BMP signaling pathway; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of osteoblast differentiation; positive regulation of phosphorylation; positive regulation of transcription, DNA-dependent; protein serine/threonine kinase activity; sarcomere" IPR002110; IPR020683; IPR016253; IPR011009; IPR000719; IPR001245; Integrin-linked protein kinase (EC 2.7.11.1) (Beta-integrin-linked kinase) ILK Cavia porcellus (Guinea pig) TR33553_c0_g1_i4 P55273 CDN2D_HUMAN 6.00E-11 GO:0000731; GO:0000082; GO:0048102; GO:0007050; GO:0004861; GO:0005829; GO:0030308; GO:0008285; GO:0043154; GO:1902230; GO:0005634; GO:0000079; GO:0009411; GO:0032526; GO:0033280; GO:0007605 Q00534 DNA synthesis involved in DNA repair; G1/S transition of mitotic cell cycle; autophagic cell death; cell cycle arrest; cyclin-dependent protein serine/threonine kinase inhibitor activity; cytosol; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; nucleus; regulation of cyclin-dependent protein serine/threonine kinase activity; response to UV; response to retinoic acid; response to vitamin D; sensory perception of sound IPR002110; IPR020683; Cyclin-dependent kinase 4 inhibitor D (p19-INK4d) CDKN2D Homo sapiens (Human) TR33553_c0_g1_i5 Q5UPG5 YL093_MIMIV 4.00E-17 IPR002110; IPR020683; Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) TR33553_c0_g1_i7 Q876L4 AKR2_SACBA 6.00E-07 GO:0016021; GO:0016746; GO:0008270 "integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR002110; IPR020683; IPR001594; Probable palmitoyltransferase AKR2 (EC 2.3.1.225) (Ankyrin repeat-containing protein AKR2) AKR2 Saccharomyces bayanus (Yeast) (Saccharomyces uvarum) TR33553_c0_g1_i8 Q71S22 INVSA_XENLA 6.00E-17 GO:0016055; GO:0005737; GO:0005856; GO:0007275 Wnt receptor signaling pathway; cytoplasm; cytoskeleton; multicellular organismal development IPR002110; IPR020683; IPR000048; Inversin-A invs-a inv1 invs-1 Xenopus laevis (African clawed frog) TR33555_c0_g1_i5 Q9TUD4 FUT1_GORGO 7.00E-30 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" FUT1 Gorilla gorilla gorilla (Lowland gorilla) TR33556_c0_g1_i1 P80363 CCB23_ORCLI 5.00E-34 GO:0005509 calcium ion binding IPR011992; IPR002048; Crustacean calcium-binding protein 23 (CCBP-23) Orconectes limosus (Spinycheek crayfish) TR33556_c0_g1_i3 Q8WWF8 CAPSL_HUMAN 2.00E-48 GO:0005509; GO:0005737 calcium ion binding; cytoplasm IPR011992; IPR018247; IPR002048; IPR001125; Calcyphosin-like protein CAPSL Homo sapiens (Human) TR33557_c0_g1_i1 Q0VCJ7 RERG_BOVIN 1.00E-72 GO:0005525; GO:0003924; GO:0005829; GO:0016020; GO:0030308; GO:0008285; GO:0005634; GO:0009725; GO:0007264 GTP binding; GTPase activity; cytosol; membrane; negative regulation of cell growth; negative regulation of cell proliferation; nucleus; response to hormone stimulus; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; Ras-related and estrogen-regulated growth inhibitor RERG Bos taurus (Bovine) TR33566_c0_g1_i1 Q04912 RON_HUMAN 2.00E-21 GO:0005524; GO:0006928; GO:0006952; GO:0045087; GO:0005887; GO:0005011; GO:0007275; GO:0043406; GO:0008284; GO:0051897; GO:0009615; GO:0007338; GO:0001725; GO:0007169 O43157; O15031; Q9ULL4 ATP binding; cellular component movement; defense response; innate immune response; integral to plasma membrane; macrophage colony-stimulating factor receptor activity; multicellular organismal development; positive regulation of MAP kinase activity; positive regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; response to virus; single fertilization; stress fiber; transmembrane receptor protein tyrosine kinase signaling pathway IPR013783; IPR014756; IPR002909; IPR011009; IPR016201; IPR000719; IPR017441; IPR001627; IPR001245; IPR008266; IPR020635; IPR016244; IPR015943; Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain] MST1R PTK8 RON Homo sapiens (Human) TR33566_c0_g2_i1 Q6BEA0 PLXA4_DANRE 3.00E-42 GO:0007411; GO:0007414; GO:0016021; GO:0005622; GO:0001763; GO:0005886; GO:0004872; GO:0007165 axon guidance; axonal defasciculation; integral to membrane; intracellular; morphogenesis of a branching structure; plasma membrane; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A4 plxna4 Danio rerio (Zebrafish) (Brachydanio rerio) TR33568_c3_g1_i1 Q8H0T9 KTNB1_ARATH 4.00E-10 GO:0080008; GO:0008352; GO:0005874; GO:0051013 Cul4-RING ubiquitin ligase complex; katanin complex; microtubule; microtubule severing IPR020472; IPR026962; IPR028021; IPR015943; IPR001680; IPR019775; IPR017986; Katanin p80 WD40 repeat-containing subunit B1 homolog At5g23430 K19M13.6 Arabidopsis thaliana (Mouse-ear cress) TR33568_c3_g2_i1 D4A929 WDR81_RAT 5.00E-67 GO:0010923; GO:0016772 "negative regulation of phosphatase activity; transferase activity, transferring phosphorus-containing groups" IPR000409; IPR011009; IPR015943; IPR001680; IPR017986; WD repeat-containing protein 81 Wdr81 Rattus norvegicus (Rat) TR33572_c0_g2_i1 Q9H0C1 ZMY12_HUMAN 2.00E-107 GO:0005622; GO:0046872 intracellular; metal ion binding IPR011990; IPR013105; IPR002893; Zinc finger MYND domain-containing protein 12 ZMYND12 Homo sapiens (Human) TR33574_c0_g2_i1 Q3TC93 H1BP3_MOUSE 2.00E-24 GO:0030217; GO:0007166; GO:0035091 T cell differentiation; cell surface receptor signaling pathway; phosphatidylinositol binding IPR001683; HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) Hs1bp3 Mus musculus (Mouse) TR33575_c0_g1_i1 O05389 YRBE_BACSU 2.00E-49 GO:0016491 oxidoreductase activity IPR016040; IPR000683; IPR004104; Uncharacterized oxidoreductase YrbE (EC 1.-.-.-) yrbE BSU27770 Bacillus subtilis (strain 168) TR33575_c0_g1_i4 Q6DKE0 DHDH_XENLA 8.00E-14 GO:0047837; GO:0047115 "D-xylose 1-dehydrogenase (NADP+) activity; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity" IPR016040; IPR000683; "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) (D-xylose 1-dehydrogenase) (D-xylose-NADP dehydrogenase) (EC 1.1.1.179) (Dimeric dihydrodiol dehydrogenase)" dhdh Xenopus laevis (African clawed frog) TR33577_c6_g1_i1 Q13489 BIRC3_HUMAN 2.00E-18 GO:0038061; GO:0035666; GO:0006915; GO:0007166; GO:0005829; GO:0045087; GO:0070266; GO:0043066; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0043123; GO:0039535; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0034138; GO:0034142; GO:0004842; GO:0008270 Q13546; O43353; Q9Y572; P57078; Q12933 NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; apoptotic process; cell surface receptor signaling pathway; cytosol; innate immune response; necroptosis; negative regulation of apoptotic process; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of RIG-I signaling pathway; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Apoptosis inhibitor 2) (API2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (IAP-1) (hIAP-1) (hIAP1) (RING finger protein 49) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 IAP1 MIHC RNF49 Homo sapiens (Human) TR33577_c6_g1_i3 Q24307 IAP2_DROME 1.00E-36 GO:0050829; GO:0043066; GO:0043154; GO:0061057; GO:0006964; GO:0033160; GO:0070534; GO:0007423; GO:0008270 "defense response to Gram-negative bacterium; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; peptidoglycan recognition protein signaling pathway; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; positive regulation of protein import into nucleus, translocation; protein K63-linked ubiquitination; sensory organ development; zinc ion binding" IPR001370; IPR001841; IPR013083; Apoptosis 2 inhibitor (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) (dIAP2) Iap2 DIHA ILP CG8293 Drosophila melanogaster (Fruit fly) TR33578_c2_g1_i1 Q641A2 EFR3A_XENLA 1.00E-178 GO:0005886 plasma membrane IPR011989; IPR016024; Protein EFR3 homolog A (Protein EFR3-like) efr3a Xenopus laevis (African clawed frog) TR33578_c2_g1_i2 Q14156 EFR3A_HUMAN 0 GO:0005622; GO:0005886 intracellular; plasma membrane IPR011989; IPR016024; Protein EFR3 homolog A (Protein EFR3-like) EFR3A KIAA0143 Homo sapiens (Human) TR33578_c4_g1_i1 Q5SPP5 EFR3B_DANRE 5.00E-36 IPR011989; IPR016024; Protein EFR3 homolog B efr3b si:ch211-203k16.1 si:ch211-215m21.18 Danio rerio (Zebrafish) (Brachydanio rerio) TR33580_c1_g1_i3 P62902 RL31_RAT 1.00E-50 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000054; IPR020052; IPR023621; 60S ribosomal protein L31 Rpl31 Rattus norvegicus (Rat) TR33580_c1_g3_i2 Q13367 AP3B2_HUMAN 0 GO:0030123; GO:0030137; GO:0008089; GO:0048490; GO:0030665; GO:0006897; GO:0006886; GO:0005634; GO:0006892; GO:0005215 AP-3 adaptor complex; COPI-coated vesicle; anterograde axon cargo transport; anterograde synaptic vesicle transport; clathrin-coated vesicle membrane; endocytosis; intracellular protein transport; nucleus; post-Golgi vesicle-mediated transport; transporter activity IPR026740; IPR026739; IPR011989; IPR016024; IPR002553; IPR008153; IPR013041; AP-3 complex subunit beta-2 (Adapter-related protein complex 3 subunit beta-2) (Adaptor protein complex AP-3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP) AP3B2 Homo sapiens (Human) TR33580_c1_g3_i4 Q13367 AP3B2_HUMAN 0 GO:0030123; GO:0030137; GO:0008089; GO:0048490; GO:0030665; GO:0006897; GO:0006886; GO:0005634; GO:0006892; GO:0005215 AP-3 adaptor complex; COPI-coated vesicle; anterograde axon cargo transport; anterograde synaptic vesicle transport; clathrin-coated vesicle membrane; endocytosis; intracellular protein transport; nucleus; post-Golgi vesicle-mediated transport; transporter activity IPR026740; IPR026739; IPR011989; IPR016024; IPR002553; IPR008153; IPR013041; AP-3 complex subunit beta-2 (Adapter-related protein complex 3 subunit beta-2) (Adaptor protein complex AP-3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP) AP3B2 Homo sapiens (Human) TR33583_c0_g1_i2 Q2KI97 GPR84_BOVIN 8.00E-06 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR000276; IPR017452; G-protein coupled receptor 84 GPR84 Bos taurus (Bovine) TR33584_c0_g1_i1 Q9TXD8 ISOHC_AGEAP 1.00E-10 GO:0005576; GO:0016853; GO:0006508; GO:0004252 extracellular region; isomerase activity; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Venom peptide isomerase heavy chain (EC 5.-.-.-) Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi) TR33584_c0_g2_i1 Q5R1M5 CELA1_FELCA 1.00E-08 GO:0016055; GO:0031017; GO:0005576; GO:0006954; GO:0046872; GO:0035264; GO:0000122; GO:0061113; GO:0045944; GO:0009791; GO:0006508; GO:0045595; GO:0042127; GO:0004252 Wnt receptor signaling pathway; exocrine pancreas development; extracellular region; inflammatory response; metal ion binding; multicellular organism growth; negative regulation of transcription from RNA polymerase II promoter; pancreas morphogenesis; positive regulation of transcription from RNA polymerase II promoter; post-embryonic development; proteolysis; regulation of cell differentiation; regulation of cell proliferation; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Chymotrypsin-like elastase family member 1 (EC 3.4.21.36) (Elastase-1) CELA1 ELA1 ELS1 Felis catus (Cat) (Felis silvestris catus) TR33584_c0_g3_i2 P27435 TRYB1_RAT 8.00E-18 GO:0005576; GO:0006508; GO:0004252 extracellular region; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; "Tryptase (EC 3.4.21.59) (Mast cell protease 7) (rMCP-7) (Tryptase alpha/beta-1) (Tryptase, skin)" Tpsab1 Mcp7 Mcpt7 Tpsb1 Rattus norvegicus (Rat) TR33584_c0_g3_i3 Q90629 TRY3_CHICK 6.00E-27 GO:0007586; GO:0005615; GO:0046872; GO:0006508; GO:0004252 digestion; extracellular space; metal ion binding; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Trypsin II-P29 (EC 3.4.21.4) Gallus gallus (Chicken) TR33584_c0_g3_i4 Q9CR35 CTRB1_MOUSE 4.00E-23 GO:0007586; GO:0005615; GO:0008233; GO:0006508; GO:0004252 digestion; extracellular space; peptidase activity; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Chymotrypsinogen B (EC 3.4.21.1) [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C] Ctrb1 Mus musculus (Mouse) TR33584_c1_g2_i1 P83425 HIP_MYTED 1.00E-07 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR33584_c1_g2_i3 Q4ZJM9 C1QL4_MOUSE 4.00E-07 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) TR33586_c3_g1_i1 O60669 MOT2_HUMAN 3.00E-24 GO:0005887; GO:0005477; GO:0015355; GO:0015293 integral to plasma membrane; pyruvate secondary active transmembrane transporter activity; secondary active monocarboxylate transmembrane transporter activity; symporter activity IPR027178; IPR011701; IPR020846; IPR016196; IPR004743; Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) SLC16A7 MCT2 Homo sapiens (Human) TR33586_c3_g1_i2 O60669 MOT2_HUMAN 2.00E-24 GO:0005887; GO:0005477; GO:0015355; GO:0015293 integral to plasma membrane; pyruvate secondary active transmembrane transporter activity; secondary active monocarboxylate transmembrane transporter activity; symporter activity IPR027178; IPR011701; IPR020846; IPR016196; IPR004743; Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) SLC16A7 MCT2 Homo sapiens (Human) TR33588_c1_g1_i2 Q6P355 DHSD_XENTR 2.00E-19 GO:0020037; GO:0016021; GO:0046872; GO:0005749; GO:0006099; GO:0048039 heme binding; integral to membrane; metal ion binding; mitochondrial respiratory chain complex II; tricarboxylic acid cycle; ubiquinone binding IPR007992; "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (CybS) (Succinate dehydrogenase complex subunit D) (Succinate-ubiquinone oxidoreductase cytochrome b small subunit) (Succinate-ubiquinone reductase membrane anchor subunit)" sdhd TNeu097k19.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33589_c0_g1_i2 Q9W6I0 UQCC_XENLA 1.00E-31 IPR021150; IPR007129; Ubiquinol-cytochrome-c reductase complex assembly factor 1 (Basic FGF-repressed Zic-binding protein homolog) (Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog) (Zic3-binding protein) uqcc1 bfzb uqcc Xenopus laevis (African clawed frog) TR3359_c1_g1_i1 Q941X2 LAC3_ORYSJ 6.00E-18 GO:0048046; GO:0005507; GO:0052716; GO:0046274 apoplast; copper ion binding; hydroquinone:oxygen oxidoreductase activity; lignin catabolic process IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; IPR017761; Laccase-3 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 3) (Diphenol oxidase 3) (Urishiol oxidase 3) LAC3 Os01g0827300 LOC_Os01g61160 B1088C09.5 Oryza sativa subsp. japonica (Rice) TR33590_c3_g1_i1 Q9Y6R4 M3K4_HUMAN 6.00E-125 GO:0005524; GO:0007254; GO:0004709; GO:0060718; GO:0005737; GO:0019100; GO:0046872; GO:0048471; GO:0001890; GO:0043507; GO:0010468 O75369; O75293; Q96B97; P0CG48 ATP binding; JNK cascade; MAP kinase kinase kinase activity; chorionic trophoblast cell differentiation; cytoplasm; male germ-line sex determination; metal ion binding; perinuclear region of cytoplasm; placenta development; positive regulation of JUN kinase activity; regulation of gene expression IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) MAP3K4 KIAA0213 MAPKKK4 MEKK4 MTK1 Homo sapiens (Human) TR33592_c2_g1_i2 Q00539 NAM8_YEAST 4.00E-06 GO:0005685; GO:0071004; GO:0000243; GO:0003729; GO:0006376; GO:0005739; GO:0000166; GO:0048026 "U1 snRNP; U2-type prespliceosome; commitment complex; mRNA binding; mRNA splice site selection; mitochondrion; nucleotide binding; positive regulation of mRNA splicing, via spliceosome" IPR012677; IPR000504; Protein NAM8 NAM8 MRE2 YHR086W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33592_c2_g1_i3 Q64368 DAZL_MOUSE 3.00E-21 GO:0005737; GO:0007281; GO:0003730; GO:0007275; GO:0000166; GO:0048477; GO:0005844; GO:0045836; GO:0045948; GO:0007283; GO:0008494 Itself; O88485; P63168 cytoplasm; germ cell development; mRNA 3'-UTR binding; multicellular organismal development; nucleotide binding; oogenesis; polysome; positive regulation of meiosis; positive regulation of translational initiation; spermatogenesis; translation activator activity IPR012677; IPR000504; Deleted in azoospermia-like (DAZ-like autosomal) (Deleted in azoospermia-like 1) Dazl Dazl1 Dazla Mus musculus (Mouse) TR33592_c2_g1_i4 Q8N9W6 BOLL_HUMAN 3.00E-42 GO:0003723; GO:0030154; GO:0005737; GO:0007126; GO:0007275; GO:0000166; GO:0045948; GO:0007283; GO:0008494 RNA binding; cell differentiation; cytoplasm; meiosis; multicellular organismal development; nucleotide binding; positive regulation of translational initiation; spermatogenesis; translation activator activity IPR012677; IPR000504; Protein boule-like BOLL BOULE Homo sapiens (Human) TR33592_c2_g1_i8 Q99383 HRP1_YEAST 3.00E-08 GO:0010494; GO:0003729; GO:0006379; GO:0005849; GO:0006378; GO:0000184; GO:0000166 P32505 "cytoplasmic stress granule; mRNA binding; mRNA cleavage; mRNA cleavage factor complex; mRNA polyadenylation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleotide binding" IPR012677; IPR000504; Nuclear polyadenylated RNA-binding protein 4 (Cleavage factor IB) (CFIB) HRP1 NAB4 NAB5 YOL123W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33592_c2_g1_i9 Q8N9W6 BOLL_HUMAN 2.00E-42 GO:0003723; GO:0030154; GO:0005737; GO:0007126; GO:0007275; GO:0000166; GO:0045948; GO:0007283; GO:0008494 RNA binding; cell differentiation; cytoplasm; meiosis; multicellular organismal development; nucleotide binding; positive regulation of translational initiation; spermatogenesis; translation activator activity IPR012677; IPR000504; Protein boule-like BOLL BOULE Homo sapiens (Human) TR33595_c1_g1_i1 Q9D306 MGT4C_MOUSE 2.00E-69 GO:0000139; GO:0008454; GO:0016021; GO:0046872; GO:0006486 "Golgi membrane; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; integral to membrane; metal ion binding; protein glycosylation" IPR006759; Protein modification; protein glycosylation. "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)" Mgat4c Mus musculus (Mouse) TR33595_c1_g1_i3 Q9D306 MGT4C_MOUSE 3.00E-69 GO:0000139; GO:0008454; GO:0016021; GO:0046872; GO:0006486 "Golgi membrane; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; integral to membrane; metal ion binding; protein glycosylation" IPR006759; Protein modification; protein glycosylation. "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)" Mgat4c Mus musculus (Mouse) TR33596_c0_g1_i1 P07201 RIR2_SPISO 0 GO:0006260; GO:0009186; GO:0046872; GO:0004748 "DNA replication; deoxyribonucleoside diphosphate metabolic process; metal ion binding; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor" IPR009078; IPR012348; IPR000358; Genetic information processing; DNA replication. Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) (Ribonucleotide reductase small subunit) (p41) Spisula solidissima (Atlantic surf-clam) TR33596_c0_g1_i2 P32209 RIR2_SWPVK 4.00E-145 GO:0006260; GO:0009186; GO:0046872; GO:0004748 "DNA replication; deoxyribonucleoside diphosphate metabolic process; metal ion binding; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor" IPR009078; IPR012348; IPR000358; Genetic information processing; DNA replication. Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) (Ribonucleotide reductase small subunit) C14L Swinepox virus (strain Kasza) (SWPV) TR33596_c0_g1_i3 P20561 YVFC_VACCC 2.00E-17 Uncharacterized 11.6 kDa protein F ORF C Vaccinia virus (strain Copenhagen) (VACV) TR33596_c0_g1_i4 P20560 YVFB_VACCC 7.00E-07 IPR020153; Uncharacterized 8.3 kDa protein F ORF B Vaccinia virus (strain Copenhagen) (VACV) TR33597_c2_g1_i1 Q9DGD1 MGT4C_CHICK 5.00E-66 GO:0000139; GO:0008454; GO:0016021; GO:0046872; GO:0006486 "Golgi membrane; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; integral to membrane; metal ion binding; protein glycosylation" IPR006759; Protein modification; protein glycosylation. "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.-) (EC 2.4.1.145) (N-acetylglucosaminyltransferase VI) (GnT-VI) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)" MGAT4C Gallus gallus (Chicken) TR33597_c2_g1_i4 Q9DGD1 MGT4C_CHICK 9.00E-66 GO:0000139; GO:0008454; GO:0016021; GO:0046872; GO:0006486 "Golgi membrane; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; integral to membrane; metal ion binding; protein glycosylation" IPR006759; Protein modification; protein glycosylation. "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.-) (EC 2.4.1.145) (N-acetylglucosaminyltransferase VI) (GnT-VI) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)" MGAT4C Gallus gallus (Chicken) TR33600_c4_g1_i2 Q91502 SC6A8_TORMA 4.00E-56 GO:0016021; GO:0005328 integral to membrane; neurotransmitter:sodium symporter activity IPR000175; Creatine transporter Torpedo marmorata (Marbled electric ray) TR33600_c4_g7_i1 P31646 S6A13_RAT 2.00E-151 GO:0005332; GO:0005887; GO:0042165; GO:0006836; GO:0005328 gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; neurotransmitter binding; neurotransmitter transport; neurotransmitter:sodium symporter activity IPR000175; IPR002981; Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13) Slc6a13 Gabt2 Gat-2 Rattus norvegicus (Rat) TR33600_c4_g7_i3 Q9XS59 S6A15_BOVIN 1.00E-26 GO:0005887; GO:0015820; GO:0005328; GO:0005298 integral to plasma membrane; leucine transport; neurotransmitter:sodium symporter activity; proline:sodium symporter activity IPR000175; IPR002438; Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Solute carrier family 6 member 15) (Transporter v7-3) SLC6A15 B0AT2 NTT73 Bos taurus (Bovine) TR33600_c4_g7_i6 Q64093 S6A20_RAT 2.00E-33 GO:0015171; GO:0016324; GO:0005887; GO:0005328 amino acid transmembrane transporter activity; apical plasma membrane; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR002438; Sodium- and chloride-dependent transporter XTRP3 (Sodium/imino-acid transporter 1) (Solute carrier family 6 member 20) (Transporter rB21A) Slc6a20 Sit1 Xtrp3 Rattus norvegicus (Rat) TR33601_c0_g1_i3 Q4V7T9 ROMO1_XENLA 4.00E-27 GO:0034614; GO:0042742; GO:0016021; GO:0005743; GO:0005739; GO:0008284; GO:2000379; GO:0001302 cellular response to reactive oxygen species; defense response to bacterium; integral to membrane; mitochondrial inner membrane; mitochondrion; positive regulation of cell proliferation; positive regulation of reactive oxygen species metabolic process; replicative cell aging IPR018450; Reactive oxygen species modulator 1 (ROS modulator 1) (Protein MGR2 homolog) romo1 Xenopus laevis (African clawed frog) TR33603_c0_g1_i1 P70398 USP9X_MOUSE 2.00E-27 GO:0030509; GO:0045177; GO:0051301; GO:0007059; GO:0070410; GO:0008234; GO:0005737; GO:0007067; GO:0016579; GO:0007179; GO:0004221; GO:0006511 A5PKW4; Q13485 BMP signaling pathway; apical part of cell; cell division; chromosome segregation; co-SMAD binding; cysteine-type peptidase activity; cytoplasm; mitosis; protein deubiquitination; transforming growth factor beta receptor signaling pathway; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR016024; IPR018200; IPR001394; "Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets homolog) (Fat facets protein-related, X-linked) (Ubiquitin carboxyl-terminal hydrolase FAM) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)" Usp9x Fafl Fam Mus musculus (Mouse) TR33603_c2_g1_i1 B1AY13 UBP24_MOUSE 2.00E-41 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR016024; IPR018200; IPR001394; IPR009060; IPR015940; Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) Usp24 Mus musculus (Mouse) TR33603_c3_g2_i1 Q9WTV6 UBP18_MOUSE 3.00E-08 GO:0032020; GO:0019785; GO:0035634; GO:0004221; GO:0006511 ISG15-protein conjugation; ISG15-specific protease activity; response to stilbenoid; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubl carboxyl-terminal hydrolase 18 (EC 3.4.19.-) (43 kDa ISG15-specific protease) (ISG15-specific-processing protease) (Ubl thioesterase 18) Usp18 Ubp43 Mus musculus (Mouse) TR33603_c5_g1_i1 B1AY13 UBP24_MOUSE 5.00E-98 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR016024; IPR018200; IPR001394; IPR009060; IPR015940; Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) Usp24 Mus musculus (Mouse) TR33604_c0_g1_i2 Q96K31 CH076_HUMAN 5.00E-12 IPR011990 Uncharacterized protein C8orf76 C8orf76 Homo sapiens (Human) TR33606_c1_g1_i1 P86802 VM1H1_BOTMA 5.00E-07 GO:0004175; GO:0005576; GO:0046872; GO:0004222; GO:0006508 endopeptidase activity; extracellular region; metal ion binding; metalloendopeptidase activity; proteolysis IPR024079; IPR001590; Snake venom metalloproteinase HF-1 (BmHF-1) (SVMP) (EC 3.4.24.-) Bothrops marajoensis (Marajo lancehead) TR33608_c1_g3_i1 Q9BTX7 TTPAL_HUMAN 3.00E-31 GO:0005622; GO:0005215 intracellular; transporter activity IPR001071; IPR001251; IPR011074; Alpha-tocopherol transfer protein-like TTPAL C20orf121 Homo sapiens (Human) TR33608_c4_g2_i1 Q9D3D0 TTPAL_MOUSE 7.00E-77 GO:0005622; GO:0005215 intracellular; transporter activity IPR001071; IPR001251; IPR011074; Alpha-tocopherol transfer protein-like Ttpal Mus musculus (Mouse) TR33609_c3_g1_i1 Q5R7A4 RAB7L_PONAB 6.00E-72 GO:0005525; GO:0005886; GO:0015031; GO:0007264 GTP binding; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-7L1 (Rab-7-like protein 1) RAB7L1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33609_c3_g1_i3 P36019 YPT53_YEAST 4.00E-24 GO:0005525; GO:0003924; GO:0006895; GO:0006897; GO:0005770; GO:0005886; GO:0006623; GO:0007264 P53845 GTP binding; GTPase activity; Golgi to endosome transport; endocytosis; late endosome; plasma membrane; protein targeting to vacuole; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; GTP-binding protein YPT53 YPT53 YNL093W N2223 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33610_c2_g4_i2 Q9P8J9 RHO3_SCHCO 7.00E-07 GO:0005525; GO:0005622; GO:0005886; GO:0007264 GTP binding; intracellular; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; GTP-binding protein Rho3 RHO3 Schizophyllum commune (Split gill fungus) TR33611_c0_g1_i1 Q9NXW9 ALKB4_HUMAN 9.00E-45 GO:0003779; GO:0031032; GO:0036090; GO:0070938; GO:0032451; GO:0046872; GO:0030496; GO:0005739; GO:0005634; GO:0016706; GO:0006482; GO:0006355; GO:0006351 "actin binding; actomyosin structure organization; cleavage furrow ingression; contractile ring; demethylase activity; metal ion binding; midbody; mitochondrion; nucleus; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; protein demethylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR027450; IPR005123; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 4) ALKBH4 ABH4 Homo sapiens (Human) TR33611_c0_g1_i5 Q9NXW9 ALKB4_HUMAN 1.00E-44 GO:0003779; GO:0031032; GO:0036090; GO:0070938; GO:0032451; GO:0046872; GO:0030496; GO:0005739; GO:0005634; GO:0016706; GO:0006482; GO:0006355; GO:0006351 "actin binding; actomyosin structure organization; cleavage furrow ingression; contractile ring; demethylase activity; metal ion binding; midbody; mitochondrion; nucleus; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; protein demethylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR027450; IPR005123; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 4) ALKBH4 ABH4 Homo sapiens (Human) TR33611_c0_g1_i8 Q9D8F1 ALKB4_MOUSE 2.00E-44 GO:0003779; GO:0031032; GO:0036090; GO:0070938; GO:0051213; GO:0046872; GO:0030496; GO:0005739; GO:0005634; GO:0006482; GO:0006355; GO:0006351 "actin binding; actomyosin structure organization; cleavage furrow ingression; contractile ring; dioxygenase activity; metal ion binding; midbody; mitochondrion; nucleus; protein demethylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR027450; IPR005123; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 4) Alkbh4 Mus musculus (Mouse) TR33612_c1_g2_i1 O35929 REM1_MOUSE 9.00E-32 GO:0005525; GO:0003924; GO:0016020; GO:0007264 GTP binding; GTPase activity; membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR017358; IPR020849; GTP-binding protein REM 1 (Rad and Gem-like GTP-binding protein 1) Rem1 Rem Mus musculus (Mouse) TR33614_c0_g1_i2 Q96EH3 MASU1_HUMAN 2.00E-28 GO:0005759; GO:0005739; GO:0070130; GO:0042273 mitochondrial matrix; mitochondrion; negative regulation of mitochondrial translation; ribosomal large subunit biogenesis IPR004394; IPR025656; Mitochondrial assembly of ribosomal large subunit protein 1 MALSU1 C7orf30 Homo sapiens (Human) TR33616_c0_g1_i1 Q8BXZ1 TMX3_MOUSE 7.00E-55 GO:0045454; GO:0009986; GO:0005789; GO:0006662; GO:0016021; GO:0003756; GO:0015035; GO:0006457 cell redox homeostasis; cell surface; endoplasmic reticulum membrane; glycerol ether metabolic process; integral to membrane; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; protein folding IPR005746; IPR012336; IPR017937; IPR013766; Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3) Tmx3 Kiaa1830 Txndc10 Mus musculus (Mouse) TR33617_c0_g1_i1 P98155 VLDLR_HUMAN 1.00E-15 GO:0034185; GO:0005509; GO:0008203; GO:0005905; GO:0034436; GO:0034437; GO:0016021; GO:0006869; GO:0005041; GO:0007613; GO:0000122; GO:0005886; GO:1900006; GO:0045860; GO:0038025; GO:0021517; GO:0034361; GO:0034189; GO:0034447; GO:0030229 apolipoprotein binding; calcium ion binding; cholesterol metabolic process; coated pit; glycoprotein transport; glycoprotein transporter activity; integral to membrane; lipid transport; low-density lipoprotein receptor activity; memory; negative regulation of transcription from RNA polymerase II promoter; plasma membrane; positive regulation of dendrite development; positive regulation of protein kinase activity; reelin receptor activity; ventral spinal cord development; very-low-density lipoprotein particle; very-low-density lipoprotein particle binding; very-low-density lipoprotein particle clearance; very-low-density lipoprotein particle receptor activity IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023415; IPR000033; IPR002172; Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) VLDLR Homo sapiens (Human) TR3362_c0_g1_i1 O75343 GCYB2_HUMAN 2.00E-113 GO:0005525; GO:0007596; GO:0005737; GO:0004383; GO:0020037; GO:0035556; GO:0046872 GTP binding; blood coagulation; cytoplasm; guanylate cyclase activity; heme binding; intracellular signal transduction; metal ion binding IPR001054; IPR018297; IPR011645; IPR011644; IPR024096; Guanylate cyclase soluble subunit beta-2 (GCS-beta-2) (EC 4.6.1.2) GUCY1B2 Homo sapiens (Human) TR3362_c0_g2_i1 P51840 GUC2E_RAT 1.00E-65 GO:0005524; GO:0005525; GO:0004383; GO:0016021; GO:0035556; GO:0005886; GO:0004672; GO:0007601 ATP binding; GTP binding; guanylate cyclase activity; integral to membrane; intracellular signal transduction; plasma membrane; protein kinase activity; visual perception IPR001054; IPR018297; IPR001828; IPR011645; IPR011009; IPR028082; IPR000719; IPR001245; Guanylyl cyclase GC-E (EC 4.6.1.2) (Guanylate cyclase 2E) Gucy2e Guc2e Rattus norvegicus (Rat) TR33623_c0_g1_i1 Q8R1N0 ZN830_MOUSE 1.00E-17 GO:0001832; GO:0051301; GO:0005694; GO:0005737; GO:0046872; GO:0007067; GO:0033260; GO:0016607 blastocyst growth; cell division; chromosome; cytoplasm; metal ion binding; mitosis; nuclear cell cycle DNA replication; nuclear speck Zinc finger protein 830 (Coiled-coil domain-containing protein 16) (Ovus mutant candidate gene 1 protein) Znf830 Ccdc16 Omcg1 Zfp830 Mus musculus (Mouse) TR33624_c2_g2_i1 Q14BI2 GRM2_MOUSE 3.00E-07 GO:0030424; GO:0005246; GO:0030054; GO:0030425; GO:0014047; GO:0001641; GO:0016021; GO:0005622; GO:0043005; GO:0042734 axon; calcium channel regulator activity; cell junction; dendrite; glutamate secretion; group II metabotropic glutamate receptor activity; integral to membrane; intracellular; neuron projection; presynaptic membrane IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR000162; IPR001458; IPR028082; Metabotropic glutamate receptor 2 (mGluR2) Grm2 Gprc1b Mglur2 Mus musculus (Mouse) TR33626_c0_g1_i1 Q2Y6U0 DNAK_NITMU 0 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK Nmul_A2239 Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849) TR33626_c0_g1_i2 P42373 DNAK_BURCE 0 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK Burkholderia cepacia (Pseudomonas cepacia) TR33626_c0_g1_i3 O35501 GRP75_CRIGR 0 GO:0005524; GO:0005739; GO:0005730; GO:0006457 ATP binding; mitochondrion; nucleolus; protein folding IPR012725; IPR018181; IPR013126; "Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9)" HSPA9 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR33626_c0_g1_i4 Q03684 BIP4_TOBAC 4.00E-172 GO:0005524; GO:0005788 ATP binding; endoplasmic reticulum lumen IPR018181; IPR013126; Luminal-binding protein 4 (BiP 4) (78 kDa glucose-regulated protein homolog 4) (GRP-78-4) BIP4 Nicotiana tabacum (Common tobacco) TR33626_c0_g1_i5 P42373 DNAK_BURCE 0 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK Burkholderia cepacia (Pseudomonas cepacia) TR33626_c0_g1_i6 O35501 GRP75_CRIGR 0 GO:0005524; GO:0005739; GO:0005730; GO:0006457 ATP binding; mitochondrion; nucleolus; protein folding IPR012725; IPR018181; IPR013126; "Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9)" HSPA9 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR33626_c0_g1_i7 O35501 GRP75_CRIGR 0 GO:0005524; GO:0005739; GO:0005730; GO:0006457 ATP binding; mitochondrion; nucleolus; protein folding IPR012725; IPR018181; IPR013126; "Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9)" HSPA9 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR33627_c0_g1_i1 Q6DBX1 MED20_DANRE 4.00E-60 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR013921; Mediator of RNA polymerase II transcription subunit 20 (Mediator complex subunit 20) (TRF-proximal protein homolog) med20 trfp si:rp71-11b17.6 Danio rerio (Zebrafish) (Brachydanio rerio) TR33627_c0_g1_i2 Q9R0X0 MED20_MOUSE 4.00E-65 GO:0001104; GO:0016592; GO:0035914 Q9BUE0 RNA polymerase II transcription cofactor activity; mediator complex; skeletal muscle cell differentiation IPR013921; Mediator of RNA polymerase II transcription subunit 20 (Mediator complex subunit 20) (TRF-proximal protein homolog) Med20 Trfp Mus musculus (Mouse) TR33628_c3_g1_i1 O00180 KCNK1_HUMAN 1.00E-05 GO:0016324; GO:0031526; GO:0005768; GO:0005242; GO:0035094; GO:0007268; GO:0008076 apical plasma membrane; brush border membrane; endosome; inward rectifier potassium channel activity; response to nicotine; synaptic transmission; voltage-gated potassium channel complex IPR003280; IPR013099; IPR003092; IPR005408; IPR001779; Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel KCNO1) KCNK1 HOHO1 KCNO1 TWIK1 Homo sapiens (Human) TR33628_c7_g1_i1 Q04073 P3A2_STRPU 7.00E-11 GO:0003677; GO:0005634; GO:0006355; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019526; IPR019525; DNA-binding protein P3A2 Strongylocentrotus purpuratus (Purple sea urchin) TR3363_c0_g1_i1 P33450 FAT_DROME 2.00E-39 GO:0005509; GO:0016339; GO:0050839; GO:0030054; GO:0000904; GO:0008283; GO:0045317; GO:0048105; GO:0045198; GO:0001737; GO:0035329; GO:0007156; GO:0007446; GO:0005887; GO:0090176; GO:0030178; GO:0008285; GO:0045571; GO:0016318; GO:0018149; GO:0004872; GO:0035159 "calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; cell junction; cell morphogenesis involved in differentiation; cell proliferation; equator specification; establishment of body hair planar orientation; establishment of epithelial cell apical/basal polarity; establishment of imaginal disc-derived wing hair orientation; hippo signaling cascade; homophilic cell adhesion; imaginal disc growth; integral to plasma membrane; microtubule cytoskeleton organization involved in establishment of planar polarity; negative regulation of Wnt receptor signaling pathway; negative regulation of cell proliferation; negative regulation of imaginal disc growth; ommatidial rotation; peptide cross-linking; receptor activity; regulation of tube length, open tracheal system" IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR013032; IPR001791; Cadherin-related tumor suppressor (Protein fat) ft CG3352 Drosophila melanogaster (Fruit fly) TR33631_c1_g1_i1 P31646 S6A13_RAT 0 GO:0005332; GO:0005887; GO:0042165; GO:0006836; GO:0005328 gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; neurotransmitter binding; neurotransmitter transport; neurotransmitter:sodium symporter activity IPR000175; IPR002981; Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13) Slc6a13 Gabt2 Gat-2 Rattus norvegicus (Rat) TR33631_c1_g1_i3 O18875 SC6A8_BOVIN 4.00E-177 GO:0005309; GO:0005887; GO:0005328 creatine:sodium symporter activity; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR002984; Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8) SLC6A8 Bos taurus (Bovine) TR33633_c0_g2_i1 Q11RU2 NUOH2_CYTH3 3.00E-26 GO:0050136; GO:0016021; GO:0005886; GO:0048038 NADH dehydrogenase (quinone) activity; integral to membrane; plasma membrane; quinone binding IPR001694; IPR018086; NADH-quinone oxidoreductase subunit H 2 (EC 1.6.99.5) (NADH dehydrogenase I subunit H 2) (NDH-1 subunit H 2) nuoH2 CHU_2620 Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469) TR33633_c1_g1_i1 Q00860 NU1M_MYTED 6.00E-151 GO:0008137; GO:0016021; GO:0005743; GO:0070469 NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial inner membrane; respiratory chain IPR001694; IPR018086; NADH-ubiquinone oxidoreductase chain 1 (EC 1.6.5.3) (NADH dehydrogenase subunit 1) ND1 Mytilus edulis (Blue mussel) TR33633_c1_g1_i2 Q00860 NU1M_MYTED 1.00E-144 GO:0008137; GO:0016021; GO:0005743; GO:0070469 NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial inner membrane; respiratory chain IPR001694; IPR018086; NADH-ubiquinone oxidoreductase chain 1 (EC 1.6.5.3) (NADH dehydrogenase subunit 1) ND1 Mytilus edulis (Blue mussel) TR33636_c1_g1_i5 Q9ULH7 MKL2_HUMAN 2.00E-32 GO:0048514; GO:0048738; GO:0005737; GO:0048568; GO:0003007; GO:0001701; GO:0001889; GO:0007517; GO:0003676; GO:0005634; GO:0045844; GO:0045944; GO:0003700; GO:0051145; GO:0003713; GO:0006351 P11831 "blood vessel morphogenesis; cardiac muscle tissue development; cytoplasm; embryonic organ development; heart morphogenesis; in utero embryonic development; liver development; muscle organ development; nucleic acid binding; nucleus; positive regulation of striated muscle tissue development; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; smooth muscle cell differentiation; transcription coactivator activity; transcription, DNA-dependent" IPR004018; IPR003034; MKL/myocardin-like protein 2 (Megakaryoblastic leukemia 2) (Myocardin-related transcription factor B) (MRTF-B) MKL2 KIAA1243 MRTFB Homo sapiens (Human) TR33637_c3_g3_i1 Q6IQ97 RBM41_DANRE 1.00E-07 GO:0003723; GO:0000166; GO:0005634; GO:0008270 RNA binding; nucleotide binding; nucleus; zinc ion binding IPR012677; IPR000504; IPR001878; RNA-binding protein 4.1 (RNA-binding motif protein 4.1) rbm4.1 rbm4 Danio rerio (Zebrafish) (Brachydanio rerio) TR33637_c3_g3_i2 Q920Q6 MSI2H_MOUSE 2.00E-99 GO:0005737; GO:0000166; GO:0008266; GO:0005844; GO:0048864 cytoplasm; nucleotide binding; poly(U) RNA binding; polysome; stem cell development IPR012677; IPR000504; RNA-binding protein Musashi homolog 2 (Musashi-2) Msi2 Msi2h Mus musculus (Mouse) TR33637_c3_g3_i3 P37838 NOP4_YEAST 9.00E-06 GO:0003723; GO:0000463; GO:0005730; GO:0000166 "RNA binding; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleolus; nucleotide binding" IPR012677; IPR000504; Nucleolar protein 4 (Nucleolar protein NOP77) NOP4 NOP77 YPL043W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33637_c3_g3_i4 Q9VVE5 MSIR6_DROME 4.00E-103 GO:0005737; GO:0000166; GO:0008266; GO:0005844; GO:0048864 cytoplasm; nucleotide binding; poly(U) RNA binding; polysome; stem cell development IPR012677; IPR000504; RNA-binding protein Musashi homolog Rbp6 Rbp6 RRM6 CG32169 Drosophila melanogaster (Fruit fly) TR33637_c3_g3_i5 Q9VVE5 MSIR6_DROME 2.00E-104 GO:0005737; GO:0000166; GO:0008266; GO:0005844; GO:0048864 cytoplasm; nucleotide binding; poly(U) RNA binding; polysome; stem cell development IPR012677; IPR000504; RNA-binding protein Musashi homolog Rbp6 Rbp6 RRM6 CG32169 Drosophila melanogaster (Fruit fly) TR33638_c0_g1_i1 Q01415 GALK2_HUMAN 2.00E-172 GO:0005524; GO:0033858; GO:0005737; GO:0004335; GO:0006012 ATP binding; N-acetylgalactosamine kinase activity; cytoplasm; galactokinase activity; galactose metabolic process IPR000705; IPR019741; IPR019539; IPR013750; IPR006204; IPR006203; IPR006206; IPR020568; IPR014721; N-acetylgalactosamine kinase (EC 2.7.1.157) (GalNAc kinase) (Galactokinase 2) GALK2 GK2 Homo sapiens (Human) TR33640_c0_g1_i1 Q8K2A8 ALG3_MOUSE 2.00E-111 GO:0052925; GO:0005789; GO:0016021; GO:0006486 "dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity; endoplasmic reticulum membrane; integral to membrane; protein glycosylation" IPR007873; Protein modification; protein glycosylation. "Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC 2.4.1.258) (Asparagine-linked glycosylation protein 3 homolog) (Dol-P-Man-dependent alpha(1-3)-mannosyltransferase) (Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase) (Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase) (Not56-like protein)" Alg3 Not Not56l Mus musculus (Mouse) TR33640_c0_g1_i2 Q24332 NT56_DROVI 2.00E-66 GO:0005789; GO:0016021; GO:0007275; GO:0016758 "endoplasmic reticulum membrane; integral to membrane; multicellular organismal development; transferase activity, transferring hexosyl groups" IPR007873; Lethal(2)neighbour of Tid protein (NOT58) l(2)not not Drosophila virilis (Fruit fly) TR33641_c1_g1_i1 P56873 SSA27_MOUSE 1.00E-24 IPR009563; Sjoegren syndrome/scleroderma autoantigen 1 homolog (Autoantigen p27 homolog) (Protein C184L) Sssca1 C184l Mus musculus (Mouse) TR33641_c1_g1_i2 O60232 SSA27_HUMAN 2.00E-15 GO:0051301; GO:0007067 Q9Q2G4 cell division; mitosis IPR009563; Sjoegren syndrome/scleroderma autoantigen 1 (Autoantigen p27) SSSCA1 Homo sapiens (Human) TR33642_c0_g1_i1 Q8CFP6 DJC27_MOUSE 6.00E-17 GO:0005525; GO:0005739; GO:0007264 GTP binding; mitochondrion; small GTPase mediated signal transduction IPR001623; IPR027417; IPR005225; IPR001806; DnaJ homolog subfamily C member 27 (Rab and DnaJ domain-containing protein) Dnajc27 Rabj Rbj Mus musculus (Mouse) TR33642_c0_g1_i2 Q0VCN3 IFT27_BOVIN 3.00E-72 GO:0005525; GO:0007264 GTP binding; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; Intraflagellar transport protein 27 homolog (IFT27) (Putative GTP-binding protein RAY-like) (Rab-like protein 4) IFT27 RABL4 RAYL Bos taurus (Bovine) TR33642_c0_g1_i4 P41925 RYL2_YARLI 3.00E-06 GO:0005525; GO:0005886; GO:0015031; GO:0007264 GTP binding; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-like GTP-binding protein RYL2 RYL2 YALI0A04367g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR33643_c3_g1_i11 Q62210 BIRC2_MOUSE 1.00E-17 GO:0035631; GO:0006915; GO:0005737; GO:0009898; GO:0070266; GO:0060546; GO:1902443; GO:0005634; GO:0001890; GO:0043123; GO:0043161; GO:0070936; GO:0070534; GO:0042981; GO:0051726; GO:2000377; GO:0006355; GO:0003713; GO:0006351; GO:0004842; GO:0008270 "CD40 receptor complex; apoptotic process; cytoplasm; internal side of plasma membrane; necroptosis; negative regulation of necroptosis; negative regulation of ripoptosome assembly involved in necroptosis; nucleus; placenta development; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; protein K63-linked ubiquitination; regulation of apoptotic process; regulation of cell cycle; regulation of reactive oxygen species metabolic process; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (Inhibitor of apoptosis protein 2) (IAP-2) (mIAP-2) (mIAP2) Birc2 Birc3 Iap2 Mus musculus (Mouse) TR33643_c3_g1_i3 Q95M72 BIRC8_PANTR 1.00E-25 GO:0006915; GO:0005737; GO:0008270 apoptotic process; cytoplasm; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis-like protein 2) (IAP-like protein 2) (ILP-2) BIRC8 ILP2 Pan troglodytes (Chimpanzee) TR33643_c3_g1_i4 Q8JHV9 BIR7A_XENLA 1.00E-29 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR33643_c3_g1_i6 P41436 IAP_GVCPM 2.00E-28 GO:0006915; GO:0008270 apoptotic process; zinc ion binding IPR001370; IPR001841; Apoptosis inhibitor IAP IAP Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) TR33643_c3_g1_i7 A2AWP0 BIRC7_MOUSE 2.00E-24 GO:0005794; GO:0006915; GO:0004869; GO:0043066; GO:0005634; GO:0042127; GO:0070247; GO:0004842; GO:0008270 Golgi apparatus; apoptotic process; cysteine-type endopeptidase inhibitor activity; negative regulation of apoptotic process; nucleus; regulation of cell proliferation; regulation of natural killer cell apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; IPR017907; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (Livin) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30 kDa subunit (Truncated livin) (p30-Livin) (tLivin)] Birc7 Livin Mus musculus (Mouse) TR33643_c3_g2_i1 Q9JIB6 BIR1F_MOUSE 2.00E-08 GO:0005524; GO:0072557; GO:0006915; GO:0071391; GO:0042742; GO:0016045; GO:0006954; GO:0045087; GO:0046872; GO:0070269 ATP binding; IPAF inflammasome complex; apoptotic process; cellular response to estrogen stimulus; defense response to bacterium; detection of bacterium; inflammatory response; innate immune response; metal ion binding; pyroptosis IPR001370; IPR007111; IPR027417; Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6) Naip6 Birc1f Naip-rs4 Mus musculus (Mouse) TR33643_c3_g3_i1 Q9R0I6 XIAP_RAT 7.00E-13 GO:0016055; GO:0006915; GO:0005829; GO:0043524; GO:0005634; GO:0048471; GO:0043234; GO:0004842; GO:0008270 Wnt receptor signaling pathway; apoptotic process; cytosol; negative regulation of neuron apoptotic process; nucleus; perinuclear region of cytoplasm; protein complex; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (rIAP-3) (rIAP3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) Xiap Api3 Birc4 Rattus norvegicus (Rat) TR33644_c2_g2_i1 Q9LRC8 BAGLU_SCUBA 2.00E-25 GO:0052748; GO:0005975; GO:0016020 baicalin beta-D-glucuronidase activity; carbohydrate metabolic process; membrane IPR005199; IPR013781; IPR017853; Baicalin-beta-D-glucuronidase (EC 3.2.1.167) (Baicalinase.) SGUS Scutellaria baicalensis (Baical skullcap) TR33644_c2_g2_i2 Q9Y251 HPSE_HUMAN 6.00E-78 GO:0004566; GO:0005975; GO:0007160; GO:0005576; GO:0006027; GO:0030200; GO:0030305; GO:0043202; GO:0005765; GO:0045121; GO:0005634; GO:0030194; GO:0051798; GO:0033690; GO:0051897; GO:0010575; GO:0046983; GO:0051797; GO:0045545; GO:0061042 beta-glucuronidase activity; carbohydrate metabolic process; cell-matrix adhesion; extracellular region; glycosaminoglycan catabolic process; heparan sulfate proteoglycan catabolic process; heparanase activity; lysosomal lumen; lysosomal membrane; membrane raft; nucleus; positive regulation of blood coagulation; positive regulation of hair follicle development; positive regulation of osteoblast proliferation; positive regulation of protein kinase B signaling cascade; positive regulation vascular endothelial growth factor production; protein dimerization activity; regulation of hair follicle development; syndecan binding; vascular wound healing IPR005199; IPR013781; IPR017853; Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit] HPSE HEP HPA HPA1 HPR1 HPSE1 HSE1 Homo sapiens (Human) TR33645_c2_g1_i1 Q14393 GAS6_HUMAN 7.00E-11 GO:0035754; GO:0005796; GO:0032148; GO:0043277; GO:0060090; GO:0005509; GO:0007050; GO:0008283; GO:0031589; GO:0035690; GO:0071333; GO:0071363; GO:0035457; GO:0009267; GO:0071307; GO:0043027; GO:0097028; GO:0005788; GO:0007167; GO:0085029; GO:0005615; GO:0019064; GO:0097241; GO:0010934; GO:0070168; GO:2000669; GO:2000352; GO:2000270; GO:0032689; GO:0050711; GO:0032715; GO:1900165; GO:1900142; GO:0033159; GO:2000533; GO:0043433; GO:0045892; GO:0032720; GO:0010804; GO:0001764; GO:0031100; GO:0017187; GO:0018105; GO:0001786; GO:0070527; GO:0031093; GO:0002576; GO:0070374; GO:0032008; GO:0001961; GO:2000510; GO:0048146; GO:0010628; GO:0003104; GO:0032825; GO:0033138; GO:0050766; GO:0046827; GO:0051897; GO:0043687; GO:0043491; GO:0072661; GO:0030296; GO:0006508; GO:0048018; GO:0040008; GO:0019079; GO:0046813; GO:0005245 P30530 "B cell chemotaxis; Golgi lumen; activation of protein kinase B activity; apoptotic cell clearance; binding, bridging; calcium ion binding; cell cycle arrest; cell proliferation; cell-substrate adhesion; cellular response to drug; cellular response to glucose stimulus; cellular response to growth factor stimulus; cellular response to interferon-alpha; cellular response to starvation; cellular response to vitamin K; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; dendritic cell differentiation; endoplasmic reticulum lumen; enzyme linked receptor protein signaling pathway; extracellular matrix assembly; extracellular space; fusion of virus membrane with host plasma membrane; hematopoietic stem cell migration to bone marrow; macrophage cytokine production; negative regulation of biomineral tissue development; negative regulation of dendritic cell apoptotic process; negative regulation of endothelial cell apoptotic process; negative regulation of fibroblast apoptotic process; negative regulation of interferon-gamma production; negative regulation of interleukin-1 secretion; negative regulation of interleukin-6 production; negative regulation of interleukin-6 secretion; negative regulation of oligodendrocyte apoptotic process; negative regulation of protein import into nucleus, translocation; negative regulation of renal albumin absorption; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; negative regulation of tumor necrosis factor production; negative regulation of tumor necrosis factor-mediated signaling pathway; neuron migration; organ regeneration; peptidyl-glutamic acid carboxylation; peptidyl-serine phosphorylation; phosphatidylserine binding; platelet aggregation; platelet alpha granule lumen; platelet degranulation; positive regulation of ERK1 and ERK2 cascade; positive regulation of TOR signaling cascade; positive regulation of cytokine-mediated signaling pathway; positive regulation of dendritic cell chemotaxis; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of glomerular filtration; positive regulation of natural killer cell differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of phagocytosis; positive regulation of protein export from nucleus; positive regulation of protein kinase B signaling cascade; post-translational protein modification; protein kinase B signaling cascade; protein targeting to plasma membrane; protein tyrosine kinase activator activity; proteolysis; receptor agonist activity; regulation of growth; viral genome replication; virion attachment, binding of host cell surface receptor; voltage-gated calcium channel activity" IPR017857; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR000294; IPR009030; IPR001791; Growth arrest-specific protein 6 (GAS-6) (AXL receptor tyrosine kinase ligand) GAS6 AXLLG Homo sapiens (Human) TR33645_c4_g1_i1 P98133 FBN1_BOVIN 2.00E-52 GO:0005509; GO:0005201; GO:0005578 calcium ion binding; extracellular matrix structural constituent; proteinaceous extracellular matrix IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR011398; IPR009030; IPR017878; Fibrillin-1 (MP340) FBN1 Bos taurus (Bovine) TR33645_c4_g3_i1 Q5RBP1 NPNT_PONAB 3.00E-16 GO:0005509; GO:0007155; GO:0030154; GO:0016020; GO:0007275; GO:0005578 calcium ion binding; cell adhesion; cell differentiation; membrane; multicellular organismal development; proteinaceous extracellular matrix IPR008985; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR000998; Nephronectin NPNT Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33646_c0_g1_i1 Q6NZ22 MET14_DANRE 3.00E-167 GO:0016422; GO:0005634 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; nucleus IPR007757; Methyltransferase-like protein 14 (EC 2.1.1.-) mettl14 zgc:77296 Danio rerio (Zebrafish) (Brachydanio rerio) TR33648_c1_g1_i1 Q08890 IDS_MOUSE 6.00E-96 GO:0004423; GO:0005764; GO:0046872; GO:0008484 iduronate-2-sulfatase activity; lysosome; metal ion binding; sulfuric ester hydrolase activity IPR017849; IPR017850; IPR000917; IPR024607; Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) Ids Mus musculus (Mouse) TR33648_c1_g1_i2 P31447 YIDJ_ECOLI 1.00E-10 GO:0046872; GO:0008484 metal ion binding; sulfuric ester hydrolase activity IPR017849; IPR017850; IPR000917; IPR024607; Uncharacterized sulfatase YidJ (EC 3.1.6.-) yidJ b3678 JW3654 Escherichia coli (strain K12) TR33649_c1_g1_i3 Q27666 SODC_HAECO 2.00E-31 GO:0005737; GO:0046872; GO:0004784; GO:0006801 cytoplasm; metal ion binding; superoxide dismutase activity; superoxide metabolic process IPR024134; IPR018152; IPR001424; Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) SOD Haemonchus contortus (Barber pole worm) TR33649_c1_g3_i1 Q751L8 SODC_ASHGO 7.00E-36 GO:0005507; GO:0005829; GO:0005739; GO:0005634; GO:0019430; GO:0004784; GO:0008270 copper ion binding; cytosol; mitochondrion; nucleus; removal of superoxide radicals; superoxide dismutase activity; zinc ion binding IPR024134; IPR018152; IPR001424; Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) SOD1 AGL321W Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR33649_c1_g3_i2 P07509 SODC_NEUCR 6.00E-35 GO:0005507; GO:0005829; GO:0005739; GO:0005634; GO:0019430; GO:0004784; GO:0008270 copper ion binding; cytosol; mitochondrion; nucleus; removal of superoxide radicals; superoxide dismutase activity; zinc ion binding IPR024134; IPR018152; IPR001424; Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) sod-1 NCU02133 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR33651_c0_g1_i1 Q8Q0U0 Y045_METMA 7.00E-22 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR33651_c0_g1_i2 P14368 V234_FOWPN 9.00E-15 IPR002110; IPR020683; IPR018272; Putative ankyrin repeat protein FPV234 (BamHI-ORF12/ORF13) FPV234 Fowlpox virus (strain NVSL) (FPV) TR33652_c2_g1_i1 Q9I922 RGN_XENLA 3.00E-50 GO:0019853; GO:0005509; GO:0006874; GO:0005737; GO:0030234; GO:0004341; GO:0005634; GO:0032781; GO:0050848; GO:0008270 L-ascorbic acid biosynthetic process; calcium ion binding; cellular calcium ion homeostasis; cytoplasm; enzyme regulator activity; gluconolactonase activity; nucleus; positive regulation of ATPase activity; regulation of calcium-mediated signaling; zinc ion binding IPR011042; IPR008367; IPR013658; IPR005511; Cofactor biosynthesis; L-ascorbate biosynthesis via UDP-alpha-D-glucuronate pathway; L-ascorbate from UDP-alpha-D-glucuronate: step 3/4. Regucalcin (RC) (Gluconolactonase) (GNL) (EC 3.1.1.17) (Senescence marker protein 30) (SMP-30) (xSMP-30) rgn Xenopus laevis (African clawed frog) TR33654_c0_g1_i1 Q96P09 BIRC8_HUMAN 2.00E-12 GO:0005829; GO:0043154; GO:0043524; GO:0005634; GO:0048471; GO:0043234; GO:0008270 cytosol; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of neuron apoptotic process; nucleus; perinuclear region of cytoplasm; protein complex; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis-like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis) BIRC8 ILP2 Homo sapiens (Human) TR33654_c0_g2_i1 O62640 PIAP_PIG 3.00E-21 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR33656_c0_g1_i1 A8XWD1 MTX1_CAEBR 2.00E-27 GO:0016021; GO:0005741; GO:0006626 integral to membrane; mitochondrial outer membrane; protein targeting to mitochondrion IPR010987; IPR017410; IPR019564; Metaxin-1 homolog (Mitochondrial outer membrane import complex protein 1) mtx-1 CBG19767 Caenorhabditis briggsae TR33656_c0_g1_i3 P47802 MTX1_MOUSE 3.00E-53 GO:0016021; GO:0005743; GO:0005741; GO:0006626 integral to membrane; mitochondrial inner membrane; mitochondrial outer membrane; protein targeting to mitochondrion IPR010987; IPR017410; IPR019564; Metaxin-1 (Mitochondrial outer membrane import complex protein 1) Mtx1 Mtx Mtxn Mus musculus (Mouse) TR33656_c0_g1_i4 Q4R3I0 MTX1_MACFA 1.00E-56 GO:0016021; GO:0005741; GO:0006626 integral to membrane; mitochondrial outer membrane; protein targeting to mitochondrion IPR010987; IPR017410; IPR019564; Metaxin-1 (Mitochondrial outer membrane import complex protein 1) MTX1 QtsA-16827 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR33657_c0_g1_i2 Q14019 COTL1_HUMAN 5.00E-34 GO:0003779; GO:0005737; GO:0005856; GO:0050832; GO:0031965 P09917 actin binding; cytoplasm; cytoskeleton; defense response to fungus; nuclear membrane IPR002108; Coactosin-like protein COTL1 CLP Homo sapiens (Human) TR33658_c0_g1_i3 Q4V786 NFIP1_XENTR 9.00E-31 GO:0000139; GO:0016021 Golgi membrane; integral to membrane IPR019325; NEDD4 family-interacting protein 1 ndfip1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33659_c0_g1_i1 Q7Z7L9 ZSCA2_HUMAN 2.00E-49 GO:0003677; GO:0030154; GO:0046872; GO:0007275; GO:0005634; GO:0003700; GO:0007283; GO:0006351 "DNA binding; cell differentiation; metal ion binding; multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity; spermatogenesis; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) ZSCAN2 ZFP29 ZNF854 Homo sapiens (Human) TR33659_c0_g1_i2 Q5R5U3 ZN271_PONAB 2.00E-45 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 271 ZNF271 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33660_c1_g1_i1 P50944 AVT4_YEAST 4.00E-07 GO:0015186; GO:0015188; GO:0005302; GO:0032974; GO:0000329; GO:0016021 L-glutamine transmembrane transporter activity; L-isoleucine transmembrane transporter activity; L-tyrosine transmembrane transporter activity; amino acid transmembrane export from vacuole; fungal-type vacuole membrane; integral to membrane IPR013057; Vacuolar amino acid transporter 4 AVT4 YNL101W N2185 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33664_c6_g1_i1 Q9Z2Q4 METH_RAT 5.00E-55 GO:0031419; GO:0005737; GO:0005542; GO:0008898; GO:0050667; GO:0008705; GO:0006479; GO:0046653; GO:0008270 cobalamin binding; cytoplasm; folic acid binding; homocysteine S-methyltransferase activity; homocysteine metabolic process; methionine synthase activity; protein methylation; tetrahydrofolate metabolic process; zinc ion binding IPR003759; IPR006158; IPR011005; IPR011822; IPR000489; IPR003726; IPR004223; Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1. Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Vitamin-B12 dependent methionine synthase) (MS) Mtr Rattus norvegicus (Rat) TR33666_c0_g1_i1 Q8BYF6 SC5A8_MOUSE 7.00E-96 GO:0016324; GO:0006915; GO:0016021; GO:0006814; GO:0015293 apical plasma membrane; apoptotic process; integral to membrane; sodium ion transport; symporter activity IPR001734; IPR019900; Sodium-coupled monocarboxylate transporter 1 (Electrogenic sodium monocarboxylate cotransporter) (Solute carrier family 5 member 8) Slc5a8 Smct Smct1 Mus musculus (Mouse) TR33668_c0_g1_i4 A2ANU3 SYNG1_MOUSE 6.00E-09 GO:0044297; GO:0030054; GO:0043198; GO:0043197; GO:0031901; GO:0060076; GO:0005887; GO:0006886; GO:0051965; GO:0014069; GO:0045211; GO:0042803; GO:0009607; GO:0097091 cell body; cell junction; dendritic shaft; dendritic spine; early endosome membrane; excitatory synapse; integral to plasma membrane; intracellular protein transport; positive regulation of synapse assembly; postsynaptic density; postsynaptic membrane; protein homodimerization activity; response to biotic stimulus; synaptic vesicle clustering IPR007593; Synapse differentiation-inducing gene protein 1 (SynDIG1) (Dispanin subfamily C member 2) (DSPC2) (Transmembrane protein 90B) Syndig1 Tmem90b Mus musculus (Mouse) TR33671_c2_g1_i1 O02751 CFDP2_BOVIN 3.00E-12 GO:0005737; GO:0005634 cytoplasm; nucleus IPR005135; IPR027124; Craniofacial development protein 2 (p97 bucentaur protein) CFDP2 BCNT Bos taurus (Bovine) TR33671_c5_g4_i1 P16423 POLR_DROME 2.00E-08 GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0046872; GO:0090305; GO:0006508 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR000477; IPR007087; IPR015880; Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM (Retrovirus-related Pol polyprotein from type II retrotransposable element R2DM) [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR33674_c3_g1_i4 A4K436 RTEL1_BOVIN 9.00E-36 GO:0051539; GO:0005524; GO:0004003; GO:0003677; GO:0006281; GO:0046872; GO:0005634; GO:0010569; GO:0000723 "4 iron, 4 sulfur cluster binding; ATP binding; ATP-dependent DNA helicase activity; DNA binding; DNA repair; metal ion binding; nucleus; regulation of double-strand break repair via homologous recombination; telomere maintenance" IPR006555; IPR010614; IPR013020; IPR014013; IPR006554; IPR027417; Regulator of telomere elongation helicase 1 (EC 3.6.4.12) RTEL1 Bos taurus (Bovine) TR33674_c3_g1_i7 Q0VGM9 RTEL1_MOUSE 6.00E-26 GO:0051539; GO:0005524; GO:0004003; GO:0003677; GO:0006281; GO:0046872; GO:0005634; GO:0010569; GO:0000723 "4 iron, 4 sulfur cluster binding; ATP binding; ATP-dependent DNA helicase activity; DNA binding; DNA repair; metal ion binding; nucleus; regulation of double-strand break repair via homologous recombination; telomere maintenance" IPR006555; IPR010614; IPR013020; IPR014013; IPR014001; IPR027417; Regulator of telomere elongation helicase 1 (EC 3.6.4.12) Rtel1 Kiaa1088 Rtel Mus musculus (Mouse) TR33674_c3_g4_i1 P0C928 RTEL1_DANRE 9.00E-78 GO:0051539; GO:0005524; GO:0004003; GO:0003677; GO:0006281; GO:0046872; GO:0005634 "4 iron, 4 sulfur cluster binding; ATP binding; ATP-dependent DNA helicase activity; DNA binding; DNA repair; metal ion binding; nucleus" IPR006555; IPR010614; IPR013020; IPR014013; IPR014001; IPR027417; Regulator of telomere elongation helicase 1 (EC 3.6.4.12) rtel1 Danio rerio (Zebrafish) (Brachydanio rerio) TR33675_c1_g1_i1 P34693 SYT1_CAEEL 7.00E-06 GO:0030054; GO:0030421; GO:0016021; GO:0007626; GO:0046872; GO:0010940; GO:0046928; GO:0043051; GO:0008021; GO:0048488; GO:0016079; GO:0030672; GO:0005215 cell junction; defecation; integral to membrane; locomotory behavior; metal ion binding; positive regulation of necrotic cell death; regulation of neurotransmitter secretion; regulation of pharyngeal pumping; synaptic vesicle; synaptic vesicle endocytosis; synaptic vesicle exocytosis; synaptic vesicle membrane; transporter activity IPR000008; IPR001565; Synaptotagmin-1 (Synaptotagmin I) snt-1 F31E8.2 Caenorhabditis elegans TR33675_c1_g2_i1 Q96PU5 NED4L_HUMAN 0 GO:0006883; GO:0005829; GO:0007588; GO:0034220; GO:0019048; GO:1901380; GO:1901017; GO:2000009; GO:1902306; GO:2000650; GO:0003085; GO:0000122; GO:0030512; GO:0005654; GO:2001259; GO:2001288; GO:0010765; GO:0019870; GO:0043161; GO:0070936; GO:0042787; GO:0003254; GO:0060306; GO:0042176; GO:2000810; GO:0086005; GO:0010038; GO:0009651; GO:0019871; GO:0006814; GO:0006367; GO:0007179; GO:0043162; GO:0004842; GO:0016032; GO:0030104 cellular sodium ion homeostasis; cytosol; excretion; ion transmembrane transport; modulation by virus of host morphology or physiology; negative regulation of potassium ion transmembrane transport; negative regulation of potassium ion transmembrane transporter activity; negative regulation of protein localization to cell surface; negative regulation of sodium ion transmembrane transport; negative regulation of sodium ion transmembrane transporter activity; negative regulation of systemic arterial blood pressure; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; nucleoplasm; positive regulation of cation channel activity; positive regulation of caveolin-mediated endocytosis; positive regulation of sodium ion transport; potassium channel inhibitor activity; proteasomal ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of membrane depolarization; regulation of membrane repolarization; regulation of protein catabolic process; regulation of tight junction assembly; regulation of ventricular cardiac muscle cell action potential; response to metal ion; response to salt stress; sodium channel inhibitor activity; sodium ion transport; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ubiquitin-protein ligase activity; viral process; water homeostasis IPR000008; IPR024928; IPR000569; IPR001202; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase NEDD4-like (EC 6.3.2.-) (NEDD4.2) (Nedd4-2) NEDD4L KIAA0439 NEDL3 Homo sapiens (Human) TR33675_c1_g2_i2 Q9VVI3 NEDD4_DROME 0 GO:0007219; GO:0016199; GO:0005737; GO:0045746; GO:0007528; GO:0005886; GO:0002092; GO:0051965; GO:0019904; GO:0031623; GO:0004842 Notch signaling pathway; axon midline choice point recognition; cytoplasm; negative regulation of Notch signaling pathway; neuromuscular junction development; plasma membrane; positive regulation of receptor internalization; positive regulation of synapse assembly; protein domain specific binding; receptor internalization; ubiquitin-protein ligase activity IPR000008; IPR000569; IPR001202; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase Nedd-4 (DNedd4) (EC 6.3.2.-) Nedd4 CG7555 Drosophila melanogaster (Fruit fly) TR33675_c1_g2_i3 Q96PU5 NED4L_HUMAN 0 GO:0006883; GO:0005829; GO:0007588; GO:0034220; GO:0019048; GO:1901380; GO:1901017; GO:2000009; GO:1902306; GO:2000650; GO:0003085; GO:0000122; GO:0030512; GO:0005654; GO:2001259; GO:2001288; GO:0010765; GO:0019870; GO:0043161; GO:0070936; GO:0042787; GO:0003254; GO:0060306; GO:0042176; GO:2000810; GO:0086005; GO:0010038; GO:0009651; GO:0019871; GO:0006814; GO:0006367; GO:0007179; GO:0043162; GO:0004842; GO:0016032; GO:0030104 cellular sodium ion homeostasis; cytosol; excretion; ion transmembrane transport; modulation by virus of host morphology or physiology; negative regulation of potassium ion transmembrane transport; negative regulation of potassium ion transmembrane transporter activity; negative regulation of protein localization to cell surface; negative regulation of sodium ion transmembrane transport; negative regulation of sodium ion transmembrane transporter activity; negative regulation of systemic arterial blood pressure; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; nucleoplasm; positive regulation of cation channel activity; positive regulation of caveolin-mediated endocytosis; positive regulation of sodium ion transport; potassium channel inhibitor activity; proteasomal ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of membrane depolarization; regulation of membrane repolarization; regulation of protein catabolic process; regulation of tight junction assembly; regulation of ventricular cardiac muscle cell action potential; response to metal ion; response to salt stress; sodium channel inhibitor activity; sodium ion transport; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ubiquitin-protein ligase activity; viral process; water homeostasis IPR000008; IPR024928; IPR000569; IPR001202; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase NEDD4-like (EC 6.3.2.-) (NEDD4.2) (Nedd4-2) NEDD4L KIAA0439 NEDL3 Homo sapiens (Human) TR33675_c1_g2_i4 P51593 HUWE1_RAT 1.00E-97 GO:0003677; GO:0006284; GO:0030154; GO:0005737; GO:0016574; GO:0005634; GO:0006513; GO:0000209; GO:0042787; GO:0004842 DNA binding; base-excision repair; cell differentiation; cytoplasm; histone ubiquitination; nucleus; protein monoubiquitination; protein polyubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000569; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase HUWE1 (EC 6.3.2.-) (HECT, UBA and WWE domain-containing protein 1) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) (Fragment)" Huwe1 Ureb1 Rattus norvegicus (Rat) TR33675_c1_g3_i1 P05130 KPC1_DROME 8.00E-14 GO:0005524; GO:0035556; GO:0004697; GO:0035206; GO:0008270 ATP binding; intracellular signal transduction; protein kinase C activity; regulation of hemocyte proliferation; zinc ion binding IPR000961; IPR000008; IPR020454; IPR011009; IPR017892; IPR002219; IPR000719; IPR017441; IPR014375; IPR002290; IPR008271; "Protein kinase C, brain isozyme (PKC) (EC 2.7.11.13) (dPKC53E(BR))" Pkc53E PKC1 CG6622 Drosophila melanogaster (Fruit fly) TR33676_c1_g1_i1 A0PJP4 RIPL1_XENTR 2.00E-16 GO:0005813; GO:0005829; GO:0003382; GO:0006886; GO:0072372; GO:1901214 centrosome; cytosol; epithelial cell morphogenesis; intracellular protein transport; primary cilium; regulation of neuron death IPR019143; IPR021563; RILP-like protein 1 (Rab-interacting lysosomal-like protein 1) rilpl1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33676_c1_g1_i2 O76878 RIPL_DROME 1.00E-31 GO:0048812 neuron projection morphogenesis IPR019143; RILP-like protein homolog CG11448 Drosophila melanogaster (Fruit fly) TR33676_c1_g2_i1 Q0P4J3 RIPL2_XENTR 3.00E-14 GO:0005813; GO:0005829; GO:0003382; GO:0006886; GO:0072372 centrosome; cytosol; epithelial cell morphogenesis; intracellular protein transport; primary cilium IPR021563; RILP-like protein 2 (Rab-interacting lysosomal-like protein 2) rilpl2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33676_c1_g2_i3 Q969X0 RIPL2_HUMAN 6.00E-13 GO:0005813; GO:0005737; GO:0005829; GO:0003382; GO:0006886; GO:0005886; GO:0072372 Itself centrosome; cytoplasm; cytosol; epithelial cell morphogenesis; intracellular protein transport; plasma membrane; primary cilium IPR021563; RILP-like protein 2 (Rab-interacting lysosomal protein-like 2) (p40phox-binding protein) RILPL2 RLP2 Homo sapiens (Human) TR33678_c0_g1_i2 A5GFX0 SLMO2_PIG 5.00E-61 GO:0005739 mitochondrion IPR006797; Protein slowmo homolog 2 SLMO2 Sus scrofa (Pig) TR33681_c2_g1_i1 Q8K0U4 HS12A_MOUSE 7.00E-45 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR33683_c2_g1_i1 Q9ESK9 RBCC1_MOUSE 3.00E-26 GO:0007254; GO:0070969; GO:0000045; GO:0007049; GO:0005829; GO:0007507; GO:0001889; GO:0043066; GO:2001237; GO:0005634; GO:0045793; GO:0001934; GO:0034045; GO:0010506; GO:0006355; GO:0006351 Q8C0J2 "JNK cascade; ULK1-ATG13-FIP200 complex; autophagic vacuole assembly; cell cycle; cytosol; heart development; liver development; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; nucleus; positive regulation of cell size; positive regulation of protein phosphorylation; pre-autophagosomal structure membrane; regulation of autophagy; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019460; RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (FAK family kinase-interacting protein of 200 kDa) (FIP200) (LaXp180) Rb1cc1 Cc1 Kiaa0203 Mus musculus (Mouse) TR33683_c2_g1_i2 Q9ESK9 RBCC1_MOUSE 2.00E-24 GO:0007254; GO:0070969; GO:0000045; GO:0007049; GO:0005829; GO:0007507; GO:0001889; GO:0043066; GO:2001237; GO:0005634; GO:0045793; GO:0001934; GO:0034045; GO:0010506; GO:0006355; GO:0006351 Q8C0J2 "JNK cascade; ULK1-ATG13-FIP200 complex; autophagic vacuole assembly; cell cycle; cytosol; heart development; liver development; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; nucleus; positive regulation of cell size; positive regulation of protein phosphorylation; pre-autophagosomal structure membrane; regulation of autophagy; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019460; RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (FAK family kinase-interacting protein of 200 kDa) (FIP200) (LaXp180) Rb1cc1 Cc1 Kiaa0203 Mus musculus (Mouse) TR33684_c0_g1_i2 Q6TXF1 ARRD3_RAT 1.00E-43 GO:0005737 cytoplasm IPR011021; IPR011022; IPR014756; Arrestin domain-containing protein 3 (Liver regeneration-related protein LRRG00048) Arrdc3 Rattus norvegicus (Rat) TR33686_c2_g1_i1 Q92734 TFG_HUMAN 2.00E-58 GO:0008219; GO:0005737; GO:0043123; GO:0004871 O15162 cell death; cytoplasm; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity IPR000270; Protein TFG (TRK-fused gene protein) TFG Homo sapiens (Human) TR33688_c0_g1_i1 Q07167 SM16_SCHMA 7.00E-06 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; 16 kDa calcium-binding protein (Egg antigen SME16) Schistosoma mansoni (Blood fluke) TR33688_c0_g1_i4 Q9S9V0 CDPKV_ARATH 3.00E-07 GO:0005524; GO:0005509; GO:0016020; GO:0004674; GO:0009751 ATP binding; calcium ion binding; membrane; protein serine/threonine kinase activity; response to salicylic acid stimulus IPR011992; IPR018247; IPR002048; IPR011009; IPR000719; IPR017441; IPR002290; Calcium-dependent protein kinase 31 (EC 2.7.11.1) CPK31 At4g04695 T19J18.7 Arabidopsis thaliana (Mouse-ear cress) TR33690_c0_g1_i5 Q9BXW4 MLP3C_HUMAN 5.00E-45 GO:0005776; GO:0000421; GO:0006914; GO:0031410; GO:0012505; GO:0005874; GO:0031090 Q9BSB4; Q676U5; Q8WXU2; Q9BQS8; O75323; O00410; Q86V97; Q8WVZ9; Q14596; Q8TD19; Q9NS23; Q8WWW0; Q15459; Q13501; Q13188; Q9UPU7; O15040; Q9GZZ9; O75385 autophagic vacuole; autophagic vacuole membrane; autophagy; cytoplasmic vesicle; endomembrane system; microtubule; organelle membrane IPR004241; IPR027731; Microtubule-associated proteins 1A/1B light chain 3C (Autophagy-related protein LC3 C) (Autophagy-related ubiquitin-like modifier LC3 C) (MAP1 light chain 3-like protein 3) (MAP1A/MAP1B light chain 3 C) (MAP1A/MAP1B LC3 C) (Microtubule-associated protein 1 light chain 3 gamma) MAP1LC3C Homo sapiens (Human) TR33690_c0_g1_i6 Q9BXW4 MLP3C_HUMAN 2.00E-45 GO:0005776; GO:0000421; GO:0006914; GO:0031410; GO:0012505; GO:0005874; GO:0031090 Q9BSB4; Q676U5; Q8WXU2; Q9BQS8; O75323; O00410; Q86V97; Q8WVZ9; Q14596; Q8TD19; Q9NS23; Q8WWW0; Q15459; Q13501; Q13188; Q9UPU7; O15040; Q9GZZ9; O75385 autophagic vacuole; autophagic vacuole membrane; autophagy; cytoplasmic vesicle; endomembrane system; microtubule; organelle membrane IPR004241; IPR027731; Microtubule-associated proteins 1A/1B light chain 3C (Autophagy-related protein LC3 C) (Autophagy-related ubiquitin-like modifier LC3 C) (MAP1 light chain 3-like protein 3) (MAP1A/MAP1B light chain 3 C) (MAP1A/MAP1B LC3 C) (Microtubule-associated protein 1 light chain 3 gamma) MAP1LC3C Homo sapiens (Human) TR33692_c0_g4_i1 Q8C3Y4 KNTC1_MOUSE 3.00E-39 GO:0051301; GO:0000777; GO:0005737; GO:0005828; GO:0007067; GO:0007093; GO:0005634; GO:0000922 cell division; condensed chromosome kinetochore; cytoplasm; kinetochore microtubule; mitosis; mitotic cell cycle checkpoint; nucleus; spindle pole IPR019527; IPR017986; Kinetochore-associated protein 1 Kntc1 Kiaa0166 Mus musculus (Mouse) TR33693_c1_g1_i1 O18158 OGT1_CAEEL 4.00E-07 GO:0006048; GO:0040024; GO:0005977; GO:0019915; GO:0005634; GO:0048471; GO:0016262; GO:0006493; GO:0006470; GO:0004722; GO:0000003 UDP-N-acetylglucosamine biosynthetic process; dauer larval development; glycogen metabolic process; lipid storage; nucleus; perinuclear region of cytoplasm; protein N-acetylglucosaminyltransferase activity; protein O-linked glycosylation; protein dephosphorylation; protein serine/threonine phosphatase activity; reproduction IPR013026; IPR011990; IPR001440; IPR019734; Protein modification; protein glycosylation. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase (EC 2.4.1.-) (O-GlcNAc) (OGT) ogt-1 K04G7.3 Caenorhabditis elegans TR33693_c1_g1_i2 Q96AE7 TTC17_HUMAN 8.00E-10 IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 17 (TPR repeat protein 17) TTC17 Homo sapiens (Human) TR33694_c1_g1_i1 P13611 CSPG2_HUMAN 1.00E-21 GO:0005796; GO:0005509; GO:0030246; GO:0005975; GO:0007155; GO:0008037; GO:0030206; GO:0030207; GO:0030208; GO:0030198; GO:0005615; GO:0008347; GO:0007507; GO:0005540; GO:0043202; GO:0007275; GO:0005578 P14780 Golgi lumen; calcium ion binding; carbohydrate binding; carbohydrate metabolic process; cell adhesion; cell recognition; chondroitin sulfate biosynthetic process; chondroitin sulfate catabolic process; dermatan sulfate biosynthetic process; extracellular matrix organization; extracellular space; glial cell migration; heart development; hyaluronic acid binding; lysosomal lumen; multicellular organismal development; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Homo sapiens (Human) TR33694_c1_g1_i2 P49013 FBP3_STRPU 2.00E-74 GO:0005509; GO:0005615 calcium ion binding; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) TR33694_c1_g1_i3 O14594 NCAN_HUMAN 3.00E-21 GO:0005796; GO:0007411; GO:0005509; GO:0030246; GO:0005975; GO:0007155; GO:0030206; GO:0030207; GO:0030208; GO:0030198; GO:0005576; GO:0005540; GO:0043202; GO:0051823 Golgi lumen; axon guidance; calcium ion binding; carbohydrate binding; carbohydrate metabolic process; cell adhesion; chondroitin sulfate biosynthetic process; chondroitin sulfate catabolic process; dermatan sulfate biosynthetic process; extracellular matrix organization; extracellular region; hyaluronic acid binding; lysosomal lumen; regulation of synapse structural plasticity IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Neurocan core protein (Chondroitin sulfate proteoglycan 3) NCAN CSPG3 NEUR Homo sapiens (Human) TR33695_c0_g1_i1 Q4R747 LRC46_MACFA 7.00E-29 IPR001611; Leucine-rich repeat-containing protein 46 LRRC46 QtsA-16355 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR33695_c0_g1_i2 Q28FY0 TILB_XENTR 9.00E-11 GO:0005929; GO:0005737 cilium; cytoplasm IPR001611; IPR003603; Protein tilB homolog (Leucine-rich repeat-containing protein 6) lrrc6 TGas012h22.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33695_c0_g1_i3 Q4R747 LRC46_MACFA 7.00E-29 IPR001611; Leucine-rich repeat-containing protein 46 LRRC46 QtsA-16355 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR33696_c1_g2_i1 Q9Y5Z4 HEBP2_HUMAN 1.00E-40 GO:0005737; GO:0005739 cytoplasm; mitochondrion IPR011256; IPR006917; Heme-binding protein 2 (Placental protein 23) (PP23) (Protein SOUL) HEBP2 C6orf34 SOUL Homo sapiens (Human) TR33698_c0_g1_i1 Q9Y6R7 FCGBP_HUMAN 4.00E-08 GO:0005737; GO:0005576 cytoplasm; extracellular region IPR003645; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) TR33705_c2_g1_i1 A6QQ71 FKBP6_BOVIN 2.00E-57 GO:0005528; GO:0016020; GO:0003755; GO:0006457 FK506 binding; membrane; peptidyl-prolyl cis-trans isomerase activity; protein folding IPR023566; IPR001179; IPR013026; IPR011990; IPR013105; IPR019734; Peptidyl-prolyl cis-trans isomerase FKBP6 (PPIase FKBP6) (EC 5.2.1.8) (FK506-binding protein 6) (FKBP-6) (Rotamase) FKBP6 Bos taurus (Bovine) TR33706_c3_g1_i1 P54644 KRAC_DICDI 1.00E-10 GO:0005524; GO:0004691; GO:0005938; GO:0043327; GO:0031154; GO:0030010; GO:0044351; GO:0000281; GO:0031036; GO:0050765; GO:0048015; GO:0005543; GO:0019887 ATP binding; cAMP-dependent protein kinase activity; cell cortex; chemotaxis to cAMP; culmination involved in sorocarp development; establishment of cell polarity; macropinocytosis; mitotic cytokinesis; myosin II filament assembly; negative regulation of phagocytosis; phosphatidylinositol-mediated signaling; phospholipid binding; protein kinase regulator activity IPR000961; IPR011009; IPR011993; IPR017892; IPR001849; IPR000719; IPR017441; IPR002290; IPR008271; RAC family serine/threonine-protein kinase homolog (EC 2.7.11.1) pkbA akt dagA DDB_G0268620 Dictyostelium discoideum (Slime mold) TR33706_c5_g1_i1 Q9ULM0 PKHH1_HUMAN 1.00E-127 GO:0005856; GO:0005543 cytoskeleton; phospholipid binding IPR019749; IPR014352; IPR019748; IPR000299; IPR000857; IPR011993; IPR001849; Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) PLEKHH1 KIAA1200 Homo sapiens (Human) TR33706_c5_g2_i1 Q55E74 FRMB_DICDI 3.00E-06 GO:0005856 cytoskeleton IPR019749; IPR014352; IPR019748; IPR000299; IPR011993; FERM domain-containing protein B frmB DDB_0190205 DDB_G0269362 Dictyostelium discoideum (Slime mold) TR33709_c0_g1_i1 Q9CWT6 DDX28_MOUSE 4.00E-62 GO:0005524; GO:0008026; GO:0003723; GO:0042645; GO:0005739; GO:0005730 ATP binding; ATP-dependent helicase activity; RNA binding; mitochondrial nucleoid; mitochondrion; nucleolus IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; Probable ATP-dependent RNA helicase DDX28 (EC 3.6.4.13) (Mitochondrial DEAD box protein 28) Ddx28 Mus musculus (Mouse) TR33711_c3_g1_i1 Q7Z6J2 GRASP_HUMAN 5.00E-15 GO:0030054; GO:0048471; GO:0045211; GO:0008104; GO:0007165 cell junction; perinuclear region of cytoplasm; postsynaptic membrane; protein localization; signal transduction IPR001478; General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein) GRASP Homo sapiens (Human) TR33711_c3_g2_i1 Q9JJA9 GRASP_MOUSE 1.00E-15 GO:0005737; GO:0006886; GO:0005641; GO:0005886; GO:0007165 cytoplasm; intracellular protein transport; nuclear envelope lumen; plasma membrane; signal transduction IPR001478; General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein) Grasp MNCb-4428 Mus musculus (Mouse) TR33712_c0_g1_i2 Q1JPB9 PA2G3_BOVIN 4.00E-26 GO:0005509; GO:0005814; GO:0060271; GO:0005576; GO:0016042; GO:0004623; GO:0006644; GO:0005886 calcium ion binding; centriole; cilium morphogenesis; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process; plasma membrane IPR001211; IPR013090; IPR016090; Group 3 secretory phospholipase A2 (EC 3.1.1.4) (Group III secretory phospholipase A2) (GIII sPLA2) (sPLA2-III) (Phosphatidylcholine 2-acylhydrolase 3) PLA2G3 Bos taurus (Bovine) TR33712_c0_g1_i3 Q7M4I5 PA2_APIDO 1.00E-22 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Phospholipase A2 (PLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (allergen Api d 1) Apis dorsata (Giant honeybee) TR33712_c0_g1_i4 Q1JPB9 PA2G3_BOVIN 5.00E-26 GO:0005509; GO:0005814; GO:0060271; GO:0005576; GO:0016042; GO:0004623; GO:0006644; GO:0005886 calcium ion binding; centriole; cilium morphogenesis; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process; plasma membrane IPR001211; IPR013090; IPR016090; Group 3 secretory phospholipase A2 (EC 3.1.1.4) (Group III secretory phospholipase A2) (GIII sPLA2) (sPLA2-III) (Phosphatidylcholine 2-acylhydrolase 3) PLA2G3 Bos taurus (Bovine) TR33712_c0_g1_i5 P04362 PA2_HELHO 5.00E-08 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Phospholipase A2 (PLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (Fragment) Heloderma horridum horridum (Mexican beaded lizard) TR33713_c0_g1_i1 Q3THG9 AASD1_MOUSE 9.00E-137 GO:0005524; GO:0002196; GO:0004813; GO:0006419; GO:0005737; GO:0046872; GO:0003676 Q62406-1 ATP binding; Ser-tRNA(Ala) hydrolase activity; alanine-tRNA ligase activity; alanyl-tRNA aminoacylation; cytoplasm; metal ion binding; nucleic acid binding IPR018165; IPR018164; IPR018163; IPR009000; IPR012947; Alanyl-tRNA editing protein Aarsd1 (Alanyl-tRNA deacylase alaX) (AlaX) (AlaXp-II) (Alanyl-tRNA synthetase domain-containing protein 1) Aarsd1 Alax Mus musculus (Mouse) TR33715_c0_g3_i3 Q9NYC9 DYH9_HUMAN 3.00E-15 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0030030; GO:0006928; GO:0035085; GO:0005874; GO:0003777; GO:0007018; GO:0007283 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; cell projection organization; cellular component movement; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement; spermatogenesis IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 9, axonemal (Axonemal beta dynein heavy chain 9) (Ciliary dynein heavy chain 9)" DNAH9 DNAH17L DNAL1 KIAA0357 Homo sapiens (Human) TR33715_c0_g3_i5 Q9C0G6 DYH6_HUMAN 1.00E-22 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 6, axonemal (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6)" DNAH6 DNAHC6 DNHL1 HL2 KIAA1697 Homo sapiens (Human) TR33716_c1_g2_i2 Q5M7X9 MUL1A_DANRE 6.00E-09 GO:0006919; GO:0042802; GO:0031307; GO:0000266; GO:0051646; GO:0030308; GO:0005777; GO:0043123; GO:0004871; GO:0004842; GO:0008270 activation of cysteine-type endopeptidase activity involved in apoptotic process; identical protein binding; integral to mitochondrial outer membrane; mitochondrial fission; mitochondrion localization; negative regulation of cell growth; peroxisome; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR022170; IPR001841; IPR013083; Protein modification; protein ubiquitination. Mitochondrial ubiquitin ligase activator of nfkb 1-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase mul1-A) mul1a mul1 zgc:92166 Danio rerio (Zebrafish) (Brachydanio rerio) TR33716_c1_g2_i3 Q8LA32 LUL4_ARATH 1.00E-06 GO:0004842; GO:0008270 ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase LUL4 (EC 6.3.2.-) (Protein LOG2-LIKE UBIQUITIN LIGASE 4) (RING finger protein 208) LUL4 RF208 At3g06140 F28L1.8 Arabidopsis thaliana (Mouse-ear cress) TR33716_c1_g2_i4 Q7ZYB4 PAIP1_XENLA 1.00E-19 GO:0003723; GO:0005737; GO:0008494 RNA binding; cytoplasm; translation activator activity IPR016024; IPR016021; IPR003890; Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Paip1 protein) (Poly(A)-binding protein-interacting protein 1) (XlPaip1) paip1 Xenopus laevis (African clawed frog) TR33716_c1_g2_i5 Q9D074 MGRN1_MOUSE 8.00E-08 GO:0005769; GO:0045744; GO:0043951; GO:0005634; GO:0005886; GO:0000209; GO:0004842; GO:0008270 P04273 early endosome; negative regulation of G-protein coupled receptor protein signaling pathway; negative regulation of cAMP-mediated signaling; nucleus; plasma membrane; protein polyubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin RING finger protein 1) Mgrn1 Kiaa0544 Mus musculus (Mouse) TR33718_c3_g1_i2 Q61510 TRI25_MOUSE 8.00E-06 GO:0030054; GO:0005737; GO:0051607; GO:0045087; GO:0005634; GO:0004842; GO:0008270 cell junction; cytoplasm; defense response to virus; innate immune response; nucleus; ubiquitin-protein ligase activity; zinc ion binding IPR001870; IPR003879; IPR008985; IPR006574; IPR018355; IPR003877; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.19) (EC 6.3.2.n3) (Estrogen-responsive finger protein) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) Trim25 Efp Zfp147 Znf147 Mus musculus (Mouse) TR33718_c3_g3_i4 Q60953 PML_MOUSE 1.00E-06 GO:0003677; GO:0006977; GO:0016605; GO:0030578; GO:0046332; GO:0007184; GO:0006919; GO:0060444; GO:0007050; GO:0045165; GO:0071353; GO:0090398; GO:0050897; GO:0007182; GO:0005829; GO:0051607; GO:0031901; GO:0032469; GO:0097191; GO:0042406; GO:0045087; GO:0042771; GO:0070059; GO:0008631; GO:0051457; GO:0019048; GO:0030099; GO:0016525; GO:0030308; GO:0008285; GO:0045930; GO:2000059; GO:0051974; GO:0032211; GO:0045892; GO:0032938; GO:0016363; GO:0031965; GO:0005730; GO:2001235; GO:0002230; GO:2001238; GO:0031065; GO:0043161; GO:0006461; GO:0050821; GO:0045343; GO:0010522; GO:2000779; GO:0001932; GO:0009411; GO:0010332; GO:0001666; GO:0048384; GO:0003713; GO:0006351; GO:0007179; GO:0008270 Q14DJ8; P25446; Q60979 "DNA binding; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; PML body; PML body organization; SMAD binding; SMAD protein import into nucleus; activation of cysteine-type endopeptidase activity involved in apoptotic process; branching involved in mammary gland duct morphogenesis; cell cycle arrest; cell fate commitment; cellular response to interleukin-4; cellular senescence; cobalt ion binding; common-partner SMAD protein phosphorylation; cytosol; defense response to virus; early endosome membrane; endoplasmic reticulum calcium ion homeostasis; extrinsic apoptotic signaling pathway; extrinsic to endoplasmic reticulum membrane; innate immune response; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic apoptotic signaling pathway in response to oxidative stress; maintenance of protein location in nucleus; modulation by virus of host morphology or physiology; myeloid cell differentiation; negative regulation of angiogenesis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of mitotic cell cycle; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; negative regulation of telomerase activity; negative regulation of telomere maintenance via telomerase; negative regulation of transcription, DNA-dependent; negative regulation of translation in response to oxidative stress; nuclear matrix; nuclear membrane; nucleolus; positive regulation of apoptotic signaling pathway; positive regulation of defense response to virus by host; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of histone deacetylation; proteasomal ubiquitin-dependent protein catabolic process; protein complex assembly; protein stabilization; regulation of MHC class I biosynthetic process; regulation of calcium ion transport into cytosol; regulation of double-strand break repair; regulation of protein phosphorylation; response to UV; response to gamma radiation; response to hypoxia; retinoic acid receptor signaling pathway; transcription coactivator activity; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; zinc ion binding" IPR021978; IPR000315; IPR001841; IPR013083; IPR017907; Protein PML Pml Mus musculus (Mouse) TR33719_c0_g2_i1 Q6A070 F179B_MOUSE 4.00E-55 IPR011989; IPR016024; Protein FAM179B Fam179b Kiaa0423 Mus musculus (Mouse) TR33719_c1_g2_i1 Q8NDM7 WDR96_HUMAN 3.00E-99 IPR015943; IPR001680; IPR017986; WD repeat-containing protein 96 WDR96 C10orf79 Homo sapiens (Human) TR33719_c2_g1_i2 Q6ZUX3 F179A_HUMAN 1.00E-18 IPR011989; IPR016024; IPR024395; Protein FAM179A FAM179A Homo sapiens (Human) TR33719_c2_g1_i4 Q6A070 F179B_MOUSE 8.00E-24 IPR011989; IPR016024; Protein FAM179B Fam179b Kiaa0423 Mus musculus (Mouse) TR3372_c0_g1_i1 O61462 RL37A_CRYST 2.00E-19 GO:0046872; GO:0005840; GO:0003735; GO:0006412 metal ion binding; ribosome; structural constituent of ribosome; translation IPR002674; IPR011331; IPR011332; 60S ribosomal protein L37a RPL37A Cryptochiton stelleri (Giant gumboot chiton) TR33722_c0_g1_i1 O88279 SLIT1_RAT 1.00E-35 GO:0048846; GO:0007420; GO:0005509; GO:0005737; GO:0033563; GO:0040023; GO:0005615; GO:0043395; GO:0008045; GO:0050919; GO:0048843; GO:0051964; GO:0031290; GO:0021510; GO:0022028 axon extension involved in axon guidance; brain development; calcium ion binding; cytoplasm; dorsal/ventral axon guidance; establishment of nucleus localization; extracellular space; heparan sulfate proteoglycan binding; motor neuron axon guidance; negative chemotaxis; negative regulation of axon extension involved in axon guidance; negative regulation of synapse assembly; retinal ganglion cell axon guidance; spinal cord development; tangential migration from the subventricular zone to the olfactory bulb IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4) Slit1 Megf4 Rattus norvegicus (Rat) TR33722_c1_g1_i1 P24014 SLIT_DROME 4.00E-54 GO:0035385; GO:0071666; GO:0016199; GO:0005509; GO:0048813; GO:0007502; GO:0035050; GO:0007427; GO:0008347; GO:0008406; GO:0008201; GO:0050929; GO:0046331; GO:0008078; GO:0001764; GO:0003151; GO:0005886; GO:0022409; GO:0005578; GO:2000274; GO:0007432 "Roundabout signaling pathway; Slit-Robo signaling complex; axon midline choice point recognition; calcium ion binding; dendrite morphogenesis; digestive tract mesoderm development; embryonic heart tube development; epithelial cell migration, open tracheal system; glial cell migration; gonad development; heparin binding; induction of negative chemotaxis; lateral inhibition; mesodermal cell migration; neuron migration; outflow tract morphogenesis; plasma membrane; positive regulation of cell-cell adhesion; proteinaceous extracellular matrix; regulation of epithelial cell migration, open tracheal system; salivary gland boundary specification" IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; IPR026906; Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) TR33726_c2_g1_i5 Q15649 ZNHI3_HUMAN 4.00E-23 GO:0005622; GO:0046872; GO:0006355; GO:0046966 "intracellular; metal ion binding; regulation of transcription, DNA-dependent; thyroid hormone receptor binding" IPR007529; Zinc finger HIT domain-containing protein 3 (HNF-4a coactivator) (Thyroid hormone receptor interactor 3) (Thyroid receptor-interacting protein 3) (TR-interacting protein 3) (TRIP-3) ZNHIT3 TRIP3 Homo sapiens (Human) TR33726_c2_g5_i2 Q5NVC2 RUN3B_PONAB 5.00E-79 IPR004012; RUN domain-containing protein 3B RUNDC3B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33727_c0_g2_i1 Q9JM83 CALM4_MOUSE 8.00E-08 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-4 (Calcium-binding protein Dd112) Calm4 Dd112 Mus musculus (Mouse) TR33727_c0_g2_i3 P41040 CALM_MAIZE 1.00E-12 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) CALM1 Zea mays (Maize) TR33727_c0_g3_i2 P07463 CALM_PARTE 7.00E-18 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) CAM GSPATT00015825001 Paramecium tetraurelia TR33728_c1_g1_i1 A3KP37 NDUF5_DANRE 8.00E-118 GO:0008168; GO:0005743 methyltransferase activity; mitochondrial inner membrane IPR013216; "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 (Probable methyltransferase C20orf7 homolog, mitochondrial) (EC 2.1.1.-)" ndufaf5 zgc:162919 Danio rerio (Zebrafish) (Brachydanio rerio) TR33728_c1_g1_i2 Q2Y9Y6 BIOC_NITMU 4.00E-23 GO:0009102; GO:0010340 biotin biosynthetic process; carboxyl-O-methyltransferase activity IPR011814; IPR013216; Cofactor biosynthesis; biotin biosynthesis. Malonyl-[acyl-carrier protein] O-methyltransferase (Malonyl-ACP O-methyltransferase) (EC 2.1.1.197) (Biotin synthesis protein BioC) bioC Nmul_A1132 Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849) TR33729_c0_g1_i1 Q5JZQ8 CLN6_CANFA 6.00E-97 GO:0008203; GO:0005788; GO:0005789; GO:0001573; GO:0030203; GO:0016021; GO:0007042; GO:0045862; GO:0042803 cholesterol metabolic process; endoplasmic reticulum lumen; endoplasmic reticulum membrane; ganglioside metabolic process; glycosaminoglycan metabolic process; integral to membrane; lysosomal lumen acidification; positive regulation of proteolysis; protein homodimerization activity Ceroid-lipofuscinosis neuronal protein 6 homolog (Protein CLN6) CLN6 Canis familiaris (Dog) (Canis lupus familiaris) TR33729_c0_g1_i3 Q5JZQ8 CLN6_CANFA 6.00E-86 GO:0008203; GO:0005788; GO:0005789; GO:0001573; GO:0030203; GO:0016021; GO:0007042; GO:0045862; GO:0042803 cholesterol metabolic process; endoplasmic reticulum lumen; endoplasmic reticulum membrane; ganglioside metabolic process; glycosaminoglycan metabolic process; integral to membrane; lysosomal lumen acidification; positive regulation of proteolysis; protein homodimerization activity Ceroid-lipofuscinosis neuronal protein 6 homolog (Protein CLN6) CLN6 Canis familiaris (Dog) (Canis lupus familiaris) TR33731_c6_g1_i1 Q9HF51 RHO3_ASHGO 3.00E-16 GO:0005525; GO:0005622; GO:0005886; GO:0007264 GTP binding; intracellular; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; GTP-binding protein RHO3 RHO3 ADL252W Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR33731_c6_g1_i2 B3LPD8 YPT11_YEAS1 7.00E-14 GO:0005525; GO:0005935; GO:0005934; GO:0005789; GO:0007264 GTP binding; cellular bud neck; cellular bud tip; endoplasmic reticulum membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; GTP-binding protein YPT11 (Rab GTPase YPT11) YPT11 SCRG_03428 Saccharomyces cerevisiae (strain RM11-1a) (Baker's yeast) TR33731_c6_g1_i3 O42819 SEC4_CANGA 2.00E-73 GO:0005525; GO:0006887; GO:0005886; GO:0015031; GO:0007264; GO:0030658 GTP binding; exocytosis; plasma membrane; protein transport; small GTPase mediated signal transduction; transport vesicle membrane IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein SEC4 SEC4 CAGL0F02123g Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) TR33731_c6_g1_i4 P35280 RAB8A_RAT 7.00E-121 GO:0019003; GO:0005525; GO:0003924; GO:0005794; GO:0048210; GO:0007409; GO:0032869; GO:0042384; GO:0030659; GO:0030425; GO:0042593; GO:0005932; GO:0043025; GO:0031513; GO:0048471; GO:0045335; GO:0030670; GO:0005886; GO:0046326; GO:0014069; GO:0072659; GO:0015031; GO:0055038; GO:0048169; GO:0051223; GO:0007264; GO:0006904 GDP binding; GTP binding; GTPase activity; Golgi apparatus; Golgi vesicle fusion to target membrane; axonogenesis; cellular response to insulin stimulus; cilium assembly; cytoplasmic vesicle membrane; dendrite; glucose homeostasis; microtubule basal body; neuronal cell body; nonmotile primary cilium; perinuclear region of cytoplasm; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane; positive regulation of glucose import; postsynaptic density; protein localization to plasma membrane; protein transport; recycling endosome membrane; regulation of long-term neuronal synaptic plasticity; regulation of protein transport; small GTPase mediated signal transduction; vesicle docking involved in exocytosis IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-8A Rab8a Rab8 Rattus norvegicus (Rat) TR33731_c6_g1_i5 P22127 RAB10_DISOM 2.00E-93 GO:0019003; GO:0005525; GO:0005794; GO:0043001; GO:0007409; GO:0061467; GO:0032869; GO:0005789; GO:0071782; GO:0071786; GO:0016197; GO:0045200; GO:0097051; GO:0032593; GO:0030670; GO:0030859; GO:0072372; GO:0055037; GO:0055038; GO:0007264; GO:0005802 GDP binding; GTP binding; Golgi apparatus; Golgi to plasma membrane protein transport; axonogenesis; basolateral protein localization; cellular response to insulin stimulus; endoplasmic reticulum membrane; endoplasmic reticulum tubular network; endoplasmic reticulum tubular network organization; endosomal transport; establishment of neuroblast polarity; establishment of protein localization to endoplasmic reticulum membrane; insulin-responsive compartment; phagocytic vesicle membrane; polarized epithelial cell differentiation; primary cilium; recycling endosome; recycling endosome membrane; small GTPase mediated signal transduction; trans-Golgi network IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-10 (ORA1) Diplobatis ommata (Ocellated electric ray) (Discopyge ommata) TR33732_c0_g1_i1 Q91VM3 WIPI4_MOUSE 4.00E-147 GO:0000045; GO:0005737; GO:0080025; GO:0032266 "autophagic vacuole assembly; cytoplasm; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding" IPR015943; IPR001680; IPR017986; WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat domain X-linked 1) (WD repeat-containing protein 45) Wdr45 DXImx38e Wdrx1 Wipi4 Mus musculus (Mouse) TR33732_c0_g1_i2 Q6BIL4 ATG18_DEBHA 6.00E-32 GO:0006914; GO:0010008; GO:0034045; GO:0015031; GO:0005774 autophagy; endosome membrane; pre-autophagosomal structure membrane; protein transport; vacuolar membrane IPR015943; IPR001680; IPR017986; Autophagy-related protein 18 ATG18 DEHA2G09438g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR33732_c0_g1_i3 Q75AQ4 HSV2_ASHGO 1.00E-42 GO:0000045; GO:0005737; GO:0030659; GO:0080025; GO:0032266; GO:0015031; GO:0005774 "autophagic vacuole assembly; cytoplasm; cytoplasmic vesicle membrane; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding; protein transport; vacuolar membrane" IPR015943; IPR001680; IPR017986; SVP1-like protein 2 HSV2 ADL134W Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR33733_c0_g1_i1 Q9JII5 DAZP1_MOUSE 7.00E-23 GO:0035613; GO:0030154; GO:0008283; GO:0005737; GO:0001893; GO:0000166; GO:0005634; GO:0007283 RNA stem-loop binding; cell differentiation; cell proliferation; cytoplasm; maternal placenta development; nucleotide binding; nucleus; spermatogenesis IPR012677; IPR000504; DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) Dazap1 Mus musculus (Mouse) TR33733_c0_g1_i3 Q98SJ2 DAZP1_XENLA 5.00E-24 GO:0003723; GO:0030154; GO:0005737; GO:0007275; GO:0000166; GO:0048477 RNA binding; cell differentiation; cytoplasm; multicellular organismal development; nucleotide binding; oogenesis IPR012677; IPR000504; DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) (Proline-rich Vg1 mRNA-binding protein) dazap1 prrp Xenopus laevis (African clawed frog) TR33733_c0_g1_i6 O75526 RMXL2_HUMAN 4.00E-11 GO:0003723; GO:0000166; GO:0005634; GO:0030529 RNA binding; nucleotide binding; nucleus; ribonucleoprotein complex IPR012677; IPR012604; IPR000504; "RNA-binding motif protein, X-linked-like-2 (Testis-specific heterogeneous nuclear ribonucleoprotein G-T) (hnRNP G-T)" RBMXL2 HNRNPGT Homo sapiens (Human) TR33734_c0_g1_i1 Q6DGF5 ZDH12_RAT 4.00E-27 GO:0016021; GO:0016746; GO:0008270 "integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Probable palmitoyltransferase ZDHHC12 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 12) (DHHC-12) Zdhhc12 Rattus norvegicus (Rat) TR3374_c0_g1_i1 Q27023 DEFI_TENMO 2.00E-06 GO:0042742; GO:0005576; GO:0045087 defense response to bacterium; extracellular region; innate immune response IPR001542; IPR003614; Tenecin-1 Tenebrio molitor (Yellow mealworm beetle) TR33741_c2_g2_i1 Q8C206 GP157_MOUSE 6.00E-21 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR022343; IPR017981; IPR000832; IPR017452; Probable G-protein coupled receptor 157 Gpr157 Mus musculus (Mouse) TR33742_c2_g1_i1 Q6DRP4 CCM2_DANRE 6.00E-29 GO:0007043; GO:0005737; GO:0007507; GO:0001570 cell-cell junction assembly; cytoplasm; heart development; vasculogenesis IPR026159; IPR011993; IPR006020; Malcavernin (Cerebral cavernous malformations protein 2 homolog) (Valentine) ccm2 vtn Danio rerio (Zebrafish) (Brachydanio rerio) TR33743_c3_g1_i1 Q6FL58 ATG1_CANGA 1.00E-20 GO:0005524; GO:0006914; GO:0034045; GO:0004674; GO:0015031 ATP binding; autophagy; pre-autophagosomal structure membrane; protein serine/threonine kinase activity; protein transport IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR022708; Serine/threonine-protein kinase ATG1 (EC 2.7.11.1) (Autophagy-related protein 1) ATG1 CAGL0L06006g Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) TR33743_c3_g2_i1 Q8IWQ3 BRSK2_HUMAN 4.00E-153 GO:0005524; GO:0000086; GO:0031532; GO:0007409; GO:0051301; GO:0005813; GO:0005737; GO:0005783; GO:0030010; GO:0006887; GO:0070059; GO:0000287; GO:0007067; GO:0018105; GO:0048471; GO:0004674; GO:0061178; GO:0050321 ATP binding; G2/M transition of mitotic cell cycle; actin cytoskeleton reorganization; axonogenesis; cell division; centrosome; cytoplasm; endoplasmic reticulum; establishment of cell polarity; exocytosis; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; magnesium ion binding; mitosis; peptidyl-serine phosphorylation; perinuclear region of cytoplasm; protein serine/threonine kinase activity; regulation of insulin secretion involved in cellular response to glucose stimulus; tau-protein kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12 Homo sapiens (Human) TR33743_c3_g2_i2 Q09136 AAPK1_PIG 9.00E-66 GO:0004679; GO:0031588; GO:0005524; GO:0016055; GO:0050405; GO:0047322; GO:0006914; GO:0042149; GO:0006695; GO:0003682; GO:0005737; GO:0006633; GO:0055089; GO:0042593; GO:0035174; GO:0008610; GO:0046872; GO:0032007; GO:0043066; GO:0050995; GO:0005634; GO:0010508; GO:0045821; GO:0042752; GO:2000505; GO:0006355; GO:0048511; GO:0050321; GO:0006351 "AMP-activated protein kinase activity; AMP-activated protein kinase complex; ATP binding; Wnt receptor signaling pathway; [acetyl-CoA carboxylase] kinase activity; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity; autophagy; cellular response to glucose starvation; cholesterol biosynthetic process; chromatin binding; cytoplasm; fatty acid biosynthetic process; fatty acid homeostasis; glucose homeostasis; histone serine kinase activity; lipid biosynthetic process; metal ion binding; negative regulation of TOR signaling cascade; negative regulation of apoptotic process; negative regulation of lipid catabolic process; nucleus; positive regulation of autophagy; positive regulation of glycolysis; regulation of circadian rhythm; regulation of energy homeostasis; regulation of transcription, DNA-dependent; rhythmic process; tau-protein kinase activity; transcription, DNA-dependent" IPR028375; IPR011009; IPR000719; IPR002290; IPR008271; 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (AMPK 63 kDa subunit) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) (Fragments) PRKAA1 AMPK1 Sus scrofa (Pig) TR33743_c5_g1_i1 Q69Z98 BRSK2_MOUSE 1.00E-21 GO:0005524; GO:0006915; GO:0007409; GO:0051301; GO:0005783; GO:0030010; GO:0006887; GO:0000287; GO:0005815; GO:0007067; GO:0018105; GO:0048471; GO:0004674; GO:0061178; GO:0050321 ATP binding; apoptotic process; axonogenesis; cell division; endoplasmic reticulum; establishment of cell polarity; exocytosis; magnesium ion binding; microtubule organizing center; mitosis; peptidyl-serine phosphorylation; perinuclear region of cytoplasm; protein serine/threonine kinase activity; regulation of insulin secretion involved in cellular response to glucose stimulus; tau-protein kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase SAD-A) Brsk2 Kiaa4256 Sada Mus musculus (Mouse) TR33745_c1_g2_i1 A4FUC9 RHPN2_BOVIN 2.00E-139 GO:0048471; GO:0007165 perinuclear region of cytoplasm; signal transduction IPR004328; IPR011072; IPR001478; Rhophilin-2 (GTP-Rho-binding protein 2) RHPN2 Bos taurus (Bovine) TR33745_c1_g3_i1 Q6ZM86 GRD2I_DANRE 6.00E-07 GO:0030054; GO:0045211 cell junction; postsynaptic membrane IPR015425; IPR001478; "Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1)" grid2ip si:ch211-147h1.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR33746_c5_g1_i1 P08051 MLR_SPISA 2.00E-70 GO:0005509; GO:0016459 calcium ion binding; myosin complex IPR011992; IPR018247; IPR002048; "Myosin regulatory light chain, smooth muscle" Spisula sachalinensis (Sakhalin surf-clam) TR33747_c0_g2_i1 A8KBY2 BRF2_DANRE 6.00E-14 GO:0006352; GO:0005634; GO:0006355; GO:0008270 "DNA-dependent transcription, initiation; nucleus; regulation of transcription, DNA-dependent; zinc ion binding" IPR013763; IPR000812; IPR013137; Transcription factor IIIB 50 kDa subunit (B-related factor 2) (BRF-2) brf2 zgc:100856 Danio rerio (Zebrafish) (Brachydanio rerio) TR3375_c0_g1_i1 Q7L804 RFIP2_HUMAN 6.00E-11 GO:0030659; GO:0005768; GO:0030010; GO:0035773; GO:0005634; GO:0005886; GO:0015031; GO:0055038; GO:0045055; GO:0055085; GO:0006833 P62491 cytoplasmic vesicle membrane; endosome; establishment of cell polarity; insulin secretion involved in cellular response to glucose stimulus; nucleus; plasma membrane; protein transport; recycling endosome membrane; regulated secretory pathway; transmembrane transport; water transport IPR000008; IPR019018; Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11) RAB11FIP2 KIAA0941 Homo sapiens (Human) TR33750_c8_g2_i1 Q28DV3 HDAC3_XENTR 0 GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0070932; GO:0070933; GO:0005634; GO:0006355; GO:0006351 "NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone H3 deacetylation; histone H4 deacetylation; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000286; IPR003084; IPR023801; Histone deacetylase 3 (HD3) (EC 3.5.1.98) hdac3 TEgg067n06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33750_c8_g2_i2 Q28DV3 HDAC3_XENTR 0 GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0070932; GO:0070933; GO:0005634; GO:0006355; GO:0006351 "NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone H3 deacetylation; histone H4 deacetylation; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000286; IPR003084; IPR023801; Histone deacetylase 3 (HD3) (EC 3.5.1.98) hdac3 TEgg067n06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33751_c3_g1_i1 Q08882 HR3_MANSE 7.00E-18 GO:0005634; GO:0043565; GO:0003707; GO:0004887; GO:0008270 nucleus; sequence-specific DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; zinc ion binding IPR008946; IPR000536; IPR001723; IPR001728; IPR001628; IPR013088; Probable nuclear hormone receptor HR3 (mHR3) (Nuclear receptor subfamily 1 group F member 4) HR3 NR1F4 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) TR33752_c0_g1_i1 Q1LUK1 QIL1_DANRE 1.00E-06 IPR026769; Protein QIL1 qil1 si:dkey-78l4.14 Danio rerio (Zebrafish) (Brachydanio rerio) TR33754_c2_g1_i1 Q5THJ4 VP13D_HUMAN 6.00E-09 IPR009060; IPR015940; IPR000449; IPR026847; IPR026854; IPR009543; Vacuolar protein sorting-associated protein 13D VPS13D KIAA0453 Homo sapiens (Human) TR33754_c2_g2_i1 Q55EI3 VP13E_DICDI 2.00E-06 GO:0005794; GO:0015031 Golgi apparatus; protein transport IPR026847; IPR026854; IPR009543; Putative vacuolar protein sorting-associated protein 13E vps13E DDB_G0268886 Dictyostelium discoideum (Slime mold) TR33754_c3_g1_i1 Q709C8 VP13C_HUMAN 2.00E-93 IPR015412; IPR026847; IPR026854; IPR009543; Vacuolar protein sorting-associated protein 13C VPS13C KIAA1421 Homo sapiens (Human) TR33754_c3_g1_i8 Q8BX70 VP13C_MOUSE 2.00E-94 IPR015412; IPR026847; IPR026854; IPR009543; Vacuolar protein sorting-associated protein 13C Vps13c Kiaa3021 Mus musculus (Mouse) TR33754_c4_g1_i3 Q54LB8 VP13A_DICDI 5.00E-36 GO:0005794; GO:0015031 Golgi apparatus; protein transport IPR015412; IPR026847; IPR026854; IPR009543; Putative vacuolar protein sorting-associated protein 13A vps13A DDB_G0286725 Dictyostelium discoideum (Slime mold) TR33759_c2_g1_i1 O58377 Y643_PYRHO 2.00E-56 GO:0003824; GO:0046872 catalytic activity; metal ion binding IPR002529; IPR011234; Uncharacterized protein PH0643 PH0643 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) TR33759_c2_g1_i2 Q6AYQ8 FAHD1_RAT 1.00E-71 GO:0018773; GO:0047621; GO:0005829; GO:0034545; GO:0046872; GO:0005743; GO:0005739 acetylpyruvate hydrolase activity; acylpyruvate hydrolase activity; cytosol; fumarylpyruvate hydrolase activity; metal ion binding; mitochondrial inner membrane; mitochondrion IPR002529; IPR011234; "Acylpyruvase FAHD1, mitochondrial (EC 3.7.1.5) (Fumarylacetoacetate hydrolase domain-containing protein 1)" Fahd1 Rattus norvegicus (Rat) TR33760_c0_g1_i1 Q61133 GSTT2_MOUSE 7.00E-44 GO:0005829; GO:0006749; GO:0004364; GO:0005634 cytosol; glutathione metabolic process; glutathione transferase activity; nucleus IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase theta-2 (EC 2.5.1.18) (GST class-theta-2) Gstt2 Mus musculus (Mouse) TR33760_c0_g1_i2 Q2NL00 GSTT1_BOVIN 1.00E-51 GO:0005737; GO:0004364 cytoplasm; glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase theta-1 (EC 2.5.1.18) (GST class-theta-1) GSTT1 Bos taurus (Bovine) TR33764_c0_g1_i1 Q7ZY56 HEAT6_XENLA 0 IPR011989; IPR016024; IPR025283; HEAT repeat-containing protein 6 heatr6 Xenopus laevis (African clawed frog) TR33764_c0_g1_i2 A1EC95 HEAT6_RAT 0 IPR011989; IPR016024; IPR025283; HEAT repeat-containing protein 6 Heatr6 Rattus norvegicus (Rat) TR33765_c0_g1_i1 A4IHY1 PSMG1_XENTR 1.00E-44 GO:0005783; GO:0043248 endoplasmic reticulum; proteasome assembly Proteasome assembly chaperone 1 psmg1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33765_c0_g1_i2 Q6DG91 PSMG1_DANRE 5.00E-39 GO:0005783; GO:0043248 endoplasmic reticulum; proteasome assembly IPR016565; Proteasome assembly chaperone 1 psmg1 wu:fl12g04 wu:fu18c08 zgc:91806 Danio rerio (Zebrafish) (Brachydanio rerio) TR33766_c0_g3_i1 P82352 SSPN_RABIT 2.00E-19 GO:0030054; GO:0016021; GO:0045211; GO:0042383 cell junction; integral to membrane; postsynaptic membrane; sarcolemma IPR007237; Sarcospan SSPN Oryctolagus cuniculus (Rabbit) TR33767_c0_g1_i2 Q9NVX0 HAUS2_HUMAN 2.00E-11 GO:0000086; GO:0005794; GO:0070652; GO:0051301; GO:0005813; GO:0051297; GO:0005829; GO:0005874; GO:0007067; GO:0005634; GO:0005819; GO:0051225 G2/M transition of mitotic cell cycle; Golgi apparatus; HAUS complex; cell division; centrosome; centrosome organization; cytosol; microtubule; mitosis; nucleus; spindle; spindle assembly IPR028346; IPR026242; HAUS augmin-like complex subunit 2 (Centrosomal protein of 27 kDa) (Cep27) HAUS2 C15orf25 CEP27 Homo sapiens (Human) TR33768_c2_g3_i2 Q9JI67 B3GT5_MOUSE 9.00E-40 GO:0000139; GO:0005783; GO:0008378; GO:0016021; GO:0006486 Golgi membrane; endoplasmic reticulum; galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (Stage-specific embryonic antigen 3 synthase) (SSEA-3 synthase) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5)" B3galt5 B3gt5 Mus musculus (Mouse) TR33769_c10_g1_i1 O75362 ZN217_HUMAN 2.00E-06 GO:0000118; GO:0046872; GO:0045892; GO:0003700; GO:0044212; GO:0006351 "histone deacetylase complex; metal ion binding; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 217 ZNF217 ZABC1 Homo sapiens (Human) TR33769_c7_g1_i1 O57415 RREB1_CHICK 2.00E-44 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Ras-responsive element-binding protein 1 (RREB-1) RREB1 Gallus gallus (Chicken) TR33769_c8_g1_i1 P08155 KRUH_DROME 6.00E-23 GO:0003677; GO:0046872; GO:0007552; GO:0045316; GO:0035075 DNA binding; metal ion binding; metamorphosis; negative regulation of compound eye photoreceptor development; response to ecdysone IPR007087; IPR015880; IPR013087; Krueppel homologous protein 1 Kr-h1 Kr-h CG9167 Drosophila melanogaster (Fruit fly) TR33769_c8_g2_i1 O95625 ZBT11_HUMAN 2.00E-12 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 11 ZBTB11 Homo sapiens (Human) TR33769_c8_g3_i1 Q9C0G0 ZN407_HUMAN 3.00E-42 GO:0003677; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR007087; IPR015880; IPR013087; IPR003604; Zinc finger protein 407 ZNF407 KIAA1703 Homo sapiens (Human) TR33769_c8_g4_i1 P57071 PRD15_HUMAN 8.00E-12 GO:0003677; GO:0046872; GO:0008168; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; methyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001214; IPR007087; IPR015880; IPR013087; PR domain zinc finger protein 15 (EC 2.1.1.-) (PR domain-containing protein 15) (Zinc finger protein 298) PRDM15 C21orf83 ZNF298 Homo sapiens (Human) TR33771_c0_g1_i3 Q3B8G4 YIPF3_XENLA 1.00E-62 GO:0005794; GO:0030154; GO:0016021; GO:0005886 Golgi apparatus; cell differentiation; integral to membrane; plasma membrane IPR026637; Protein YIPF3 (YIP1 family member 3) yipf3 Xenopus laevis (African clawed frog) TR33772_c0_g1_i1 P70031 CCKAR_XENLA 2.00E-10 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR009126; IPR000276; IPR017452; Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) TR33773_c3_g1_i1 Q9Y115 UN93L_DROME 3.00E-39 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR010291; IPR016196; UNC93-like protein CG4928 Drosophila melanogaster (Fruit fly) TR33773_c3_g1_i6 Q9Y115 UN93L_DROME 3.00E-39 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR010291; IPR016196; UNC93-like protein CG4928 Drosophila melanogaster (Fruit fly) TR33775_c0_g4_i1 Q3ZBL4 LZTL1_BOVIN 3.00E-37 GO:0005737; GO:0072594 cytoplasm; establishment of protein localization to organelle IPR026157; Leucine zipper transcription factor-like protein 1 LZTFL1 Bos taurus (Bovine) TR33775_c0_g4_i3 Q562C6 LZTL1_RAT 3.00E-38 GO:0005737; GO:0072594 cytoplasm; establishment of protein localization to organelle IPR026157; Leucine zipper transcription factor-like protein 1 Lztfl1 Rattus norvegicus (Rat) TR33776_c0_g1_i1 O94919 ENDD1_HUMAN 1.00E-24 GO:0004519; GO:0005576; GO:0046872; GO:0003676; GO:0090305 endonuclease activity; extracellular region; metal ion binding; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis IPR001604; IPR020821; Endonuclease domain-containing 1 protein (EC 3.1.30.-) ENDOD1 KIAA0830 Homo sapiens (Human) TR33776_c0_g1_i2 P38447 NUCG_BOVIN 2.00E-06 GO:0006309; GO:0004519; GO:0001701; GO:0046872; GO:0005739; GO:0003676; GO:0043065; GO:0046677; GO:0034612 apoptotic DNA fragmentation; endonuclease activity; in utero embryonic development; metal ion binding; mitochondrion; nucleic acid binding; positive regulation of apoptotic process; response to antibiotic; response to tumor necrosis factor IPR018524; IPR001604; IPR020821; "Endonuclease G, mitochondrial (Endo G) (EC 3.1.30.-)" ENDOG Bos taurus (Bovine) TR33777_c0_g1_i1 Q5FW42 DCTN2_XENTR 9.00E-116 GO:0005737; GO:0005869; GO:0030286; GO:0016020; GO:0005874; GO:0005815; GO:0007017; GO:0007067; GO:0003774; GO:0031982 cytoplasm; dynactin complex; dynein complex; membrane; microtubule; microtubule organizing center; microtubule-based process; mitosis; motor activity; vesicle IPR028133; Dynactin subunit 2 dctn2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33779_c0_g2_i3 Q9Y6H3 ATP23_HUMAN 5.00E-27 GO:0004677; GO:0005958; GO:0006303; GO:0046872; GO:0004222; GO:0006508 DNA-dependent protein kinase activity; DNA-dependent protein kinase-DNA ligase 4 complex; double-strand break repair via nonhomologous end joining; metal ion binding; metalloendopeptidase activity; proteolysis IPR019165; Mitochondrial inner membrane protease ATP23 homolog (EC 3.4.24.-) (Ku70-binding protein 3) (XRCC6-binding protein 1) XRCC6BP1 KUB3 Homo sapiens (Human) TR33780_c0_g1_i2 O43929 ORC4_HUMAN 1.00E-164 GO:0005524; GO:0006270; GO:0003688; GO:0000082; GO:0005664; GO:0005654; GO:0017111; GO:0000166 Q13416; Q9UBD5; O43913 ATP binding; DNA replication initiation; DNA replication origin binding; G1/S transition of mitotic cell cycle; nuclear origin of replication recognition complex; nucleoplasm; nucleoside-triphosphatase activity; nucleotide binding IPR003593; IPR016527; IPR027417; Origin recognition complex subunit 4 ORC4 ORC4L Homo sapiens (Human) TR33782_c2_g3_i3 Q9R1R2 TRIM3_MOUSE 1.00E-07 GO:0005737; GO:0005769; GO:0015031; GO:0008270 cytoplasm; early endosome; protein transport; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) TR33783_c0_g1_i1 Q8UWA5 CAH2_TRIHK 3.00E-74 GO:0004089; GO:0005737; GO:0006730; GO:0005886; GO:0008270 carbonate dehydratase activity; cytoplasm; one-carbon metabolic process; plasma membrane; zinc ion binding IPR001148; IPR023561; IPR018338; Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II) ca2 Tribolodon hakonensis (Big-scaled redfin) (Leuciscus hakonensis) TR33783_c0_g1_i3 Q8UWA5 CAH2_TRIHK 5.00E-73 GO:0004089; GO:0005737; GO:0006730; GO:0005886; GO:0008270 carbonate dehydratase activity; cytoplasm; one-carbon metabolic process; plasma membrane; zinc ion binding IPR001148; IPR023561; IPR018338; Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II) ca2 Tribolodon hakonensis (Big-scaled redfin) (Leuciscus hakonensis) TR33784_c0_g1_i1 Q5SPC5 OTOF_DANRE 1.00E-102 GO:0016323; GO:0005509; GO:0030054; GO:0005789; GO:0016021; GO:0016079; GO:0030672 basolateral plasma membrane; calcium ion binding; cell junction; endoplasmic reticulum membrane; integral to membrane; synaptic vesicle exocytosis; synaptic vesicle membrane IPR000008; IPR012968; IPR012561; Otoferlin (Fer-1-like protein 2) otof fer1l2 si:dkey-181f18.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR33786_c0_g1_i1 O14792 HS3S1_HUMAN 9.00E-81 GO:0005796; GO:0008467; GO:0005975; GO:0006024; GO:0016021; GO:0044281; GO:0008146 Golgi lumen; [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity; carbohydrate metabolic process; glycosaminoglycan biosynthetic process; integral to membrane; small molecule metabolic process; sulfotransferase activity IPR027417; IPR000863; Heparan sulfate glucosamine 3-O-sulfotransferase 1 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1) (3-OST-1) (Heparan sulfate 3-O-sulfotransferase 1) (h3-OST-1) HS3ST1 3OST 3OST1 Homo sapiens (Human) TR33788_c0_g1_i1 Q8BGH2 SAM50_MOUSE 5.00E-133 GO:0016021; GO:0005743; GO:0001401; GO:0045040 integral to membrane; mitochondrial inner membrane; mitochondrial sorting and assembly machinery complex; protein import into mitochondrial outer membrane IPR000184; Sorting and assembly machinery component 50 homolog Samm50 Mus musculus (Mouse) TR33792_c0_g1_i1 Q9P0M2 AKA7G_HUMAN 5.00E-19 GO:0016208; GO:0030315; GO:0016324; GO:0003824; GO:0005829; GO:0070382; GO:0008152; GO:0005634; GO:0043234; GO:0051018; GO:0010738; GO:0016529 AMP binding; T-tubule; apical plasma membrane; catalytic activity; cytosol; exocytic vesicle; metabolic process; nucleus; protein complex; protein kinase A binding; regulation of protein kinase A signaling cascade; sarcoplasmic reticulum IPR019510; IPR019511; IPR009097; A-kinase anchor protein 7 isoform gamma (AKAP-7 isoform gamma) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoform gamma) (PRKA7 isoform gamma) AKAP7 AKAP18 Homo sapiens (Human) TR33792_c0_g1_i2 Q8BTN6 LENG9_MOUSE 6.00E-26 GO:0003824; GO:0008152; GO:0046872 catalytic activity; metabolic process; metal ion binding IPR019510; IPR009097; IPR000571; Leukocyte receptor cluster member 9 Leng9 Mus musculus (Mouse) TR33793_c1_g1_i2 B5X2B8 ERAL1_SALSA 2.00E-42 GO:0005525; GO:0005743; GO:0005759; GO:0019843; GO:0000028; GO:0043024 GTP binding; mitochondrial inner membrane; mitochondrial matrix; rRNA binding; ribosomal small subunit assembly; ribosomal small subunit binding IPR005662; IPR006073; IPR015946; IPR004044; IPR009019; IPR027417; IPR005225; "GTPase Era, mitochondrial (ERA-like protein 1)" eral1 Salmo salar (Atlantic salmon) TR33793_c1_g1_i4 O82653 ERG_ARATH 2.00E-16 GO:0005525; GO:0003723; GO:0005829 GTP binding; RNA binding; cytosol IPR005662; IPR006073; IPR015946; IPR004044; IPR009019; IPR027417; IPR005225; GTP-binding protein ERG ERG At1g30960 F17F8.15 Arabidopsis thaliana (Mouse-ear cress) TR33795_c2_g2_i1 Q8BIZ6 SNIP1_MOUSE 1.00E-81 GO:0007249; GO:0005737; GO:0005634; GO:0035196; GO:0006355 "I-kappaB kinase/NF-kappaB cascade; cytoplasm; nucleus; production of miRNAs involved in gene silencing by miRNA; regulation of transcription, DNA-dependent" IPR000253; IPR008984; Smad nuclear-interacting protein 1 Snip1 Mus musculus (Mouse) TR33795_c4_g1_i1 Q07DV3 ASZ1_AOTNA 1.00E-06 GO:0043046; GO:0030154; GO:0031047; GO:0007140; GO:0007275; GO:0071546; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; cell differentiation; gene silencing by RNA; male meiosis; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002110; IPR020683; IPR021129; "Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)" ASZ1 GASZ Aotus nancymaae (Ma's night monkey) TR33795_c4_g2_i2 Q9XSM3 TRPV5_RABIT 2.00E-08 GO:0016324; GO:0005262; GO:0005887; GO:0051262 apical plasma membrane; calcium channel activity; integral to plasma membrane; protein tetramerization IPR002110; IPR020683; IPR005821; IPR004729; IPR024862; IPR008346; IPR008344; Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Epithelial calcium channel 1) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3) Trpv5 Ecac1 Oryctolagus cuniculus (Rabbit) TR33795_c4_g2_i3 Q0JKV1 AKT1_ORYSJ 2.00E-06 GO:0016021; GO:0005249 integral to membrane; voltage-gated potassium channel activity IPR002110; IPR020683; IPR018490; IPR000595; IPR005821; IPR021789; IPR003938; IPR014710; Potassium channel AKT1 (OsAKT1) AKT1 Os01g0648000 LOC_Os01g45990 Oryza sativa subsp. japonica (Rice) TR33795_c4_g2_i4 Q08E43 ASB8_BOVIN 1.00E-06 GO:0005737; GO:0035556; GO:0016567 cytoplasm; intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 8 (ASB-8) ASB8 Bos taurus (Bovine) TR33796_c0_g2_i1 P18433 PTPRA_HUMAN 7.00E-25 GO:0007411; GO:0008286; GO:0005887; GO:0006468; GO:0005001 P14781; P39688; P62993; P00523; P12931 axon guidance; insulin receptor signaling pathway; integral to plasma membrane; protein phosphorylation; transmembrane receptor protein tyrosine phosphatase activity IPR000387; IPR016130; IPR000242; IPR016336; IPR027262; Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) TR33796_c0_g2_i2 P23469 PTPRE_HUMAN 1.00E-25 GO:0005737; GO:0016021; GO:0045111; GO:0046627; GO:0005634; GO:0005886; GO:0033003; GO:0005001; GO:0007185 cytoplasm; integral to membrane; intermediate filament cytoskeleton; negative regulation of insulin receptor signaling pathway; nucleus; plasma membrane; regulation of mast cell activation; transmembrane receptor protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase signaling pathway IPR000387; IPR016130; IPR000242; IPR016336; Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) TR33798_c0_g1_i1 Q5PPI9 TTLL1_RAT 2.00E-06 GO:0005737; GO:0016874; GO:0005874; GO:0018095 cytoplasm; ligase activity; microtubule; protein polyglutamylation IPR004344; IPR027750; Probable tubulin polyglutamylase TTLL1 (EC 6.-.-.-) (Tubulin polyglutamylase complex subunit 3) (PGs3) (Tubulin--tyrosine ligase-like protein 1) Ttll1 Rattus norvegicus (Rat) TR33798_c0_g2_i1 P38254 TTL_YEAST 3.00E-09 GO:0006464; GO:0000932; GO:0016787; GO:0004835 cellular protein modification process; cytoplasmic mRNA processing body; hydrolase activity; tubulin-tyrosine ligase activity IPR027747; IPR002828; IPR004344; Probable tubulin--tyrosine ligase PBY1 (EC 6.3.2.25) (P-body-associated protein 1) PBY1 YBR094W YBR0821 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33798_c0_g2_i2 O95922 TTLL1_HUMAN 0 GO:0035083; GO:0005737; GO:0003351; GO:0005874; GO:0018095; GO:0070740 cilium axoneme assembly; cytoplasm; epithelial cilium movement; microtubule; protein polyglutamylation; tubulin-glutamic acid ligase activity IPR004344; IPR027750; Probable tubulin polyglutamylase TTLL1 (EC 6.-.-.-) (Tubulin polyglutamylase complex subunit 3) (PGs3) (Tubulin--tyrosine ligase-like protein 1) TTLL1 C22orf7 Homo sapiens (Human) TR33798_c1_g1_i2 Q9JMG6 TFPT_RAT 6.00E-14 GO:0003677; GO:0006310; GO:0006281; GO:0031011; GO:0006915; GO:0097190; GO:0005737; GO:0005634; GO:0043065; GO:0046982; GO:0006355; GO:0006351 Q62627 "DNA binding; DNA recombination; DNA repair; Ino80 complex; apoptotic process; apoptotic signaling pathway; cytoplasm; nucleus; positive regulation of apoptotic process; protein heterodimerization activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" TCF3 fusion partner homolog (Protein amida) Tfpt Amida Rattus norvegicus (Rat) TR33799_c2_g1_i1 Q5XJ85 MYD88_DANRE 5.00E-18 GO:0002755; GO:0002218; GO:0005737; GO:0006954; GO:0045087; GO:0043123; GO:0002237 MyD88-dependent toll-like receptor signaling pathway; activation of innate immune response; cytoplasm; inflammatory response; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; response to molecule of bacterial origin IPR011029; IPR000488; IPR017281; IPR000157; Myeloid differentiation primary response protein MyD88 myd88 Danio rerio (Zebrafish) (Brachydanio rerio) TR33799_c2_g1_i2 Q5XJ85 MYD88_DANRE 2.00E-18 GO:0002755; GO:0002218; GO:0005737; GO:0006954; GO:0045087; GO:0043123; GO:0002237 MyD88-dependent toll-like receptor signaling pathway; activation of innate immune response; cytoplasm; inflammatory response; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; response to molecule of bacterial origin IPR011029; IPR000488; IPR017281; IPR000157; Myeloid differentiation primary response protein MyD88 myd88 Danio rerio (Zebrafish) (Brachydanio rerio) TR33800_c0_g1_i1 O96433 CCNT_DROME 3.00E-35 GO:0032783; GO:0008353; GO:0007015; GO:0016538; GO:0005703; GO:0008024; GO:0008360; GO:0000079; GO:0006355; GO:0009408; GO:0006351 "ELL-EAF complex; RNA polymerase II carboxy-terminal domain kinase activity; actin filament organization; cyclin-dependent protein serine/threonine kinase regulator activity; polytene chromosome puff; positive transcription elongation factor complex b; regulation of cell shape; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription, DNA-dependent; response to heat; transcription, DNA-dependent" IPR013763; IPR015429; IPR006671; IPR015430; Cyclin-T CycT CG6292 Drosophila melanogaster (Fruit fly) TR33800_c0_g1_i2 O88874 CCNK_MOUSE 8.00E-117 GO:0008353; GO:0051301; GO:0004693; GO:0001701; GO:0007067; GO:0071157; GO:0000079; GO:0006355; GO:0006351 "RNA polymerase II carboxy-terminal domain kinase activity; cell division; cyclin-dependent protein serine/threonine kinase activity; in utero embryonic development; mitosis; negative regulation of cell cycle arrest; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR013763; IPR015429; IPR006671; Cyclin-K Ccnk Mus musculus (Mouse) TR33806_c0_g1_i1 Q9ZT48 ATE1_ARATH 4.00E-20 GO:0004057; GO:0010150; GO:0016598; GO:0050994; GO:0010029; GO:0009737 arginyltransferase activity; leaf senescence; protein arginylation; regulation of lipid catabolic process; regulation of seed germination; response to abscisic acid stimulus IPR016181; IPR017137; IPR007472; IPR007471; Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) ATE1 At5g05700 MJJ3.10 Arabidopsis thaliana (Mouse-ear cress) TR33806_c0_g1_i2 O95260 ATE1_HUMAN 1.00E-34 GO:0004057; GO:0005737; GO:0005634; GO:0016598 O43463 arginyltransferase activity; cytoplasm; nucleus; protein arginylation IPR016181; IPR017137; IPR007472; IPR007471; Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) ATE1 Homo sapiens (Human) TR33806_c0_g2_i2 Q3KA78 ATE_PSEPF 2.00E-14 GO:0004057; GO:0005737; GO:0016598 arginyltransferase activity; cytoplasm; protein arginylation IPR016181; IPR007472; IPR017138; IPR007471; Putative arginyl-tRNA--protein transferase (Arginyltransferase) (R-transferase) (EC 2.3.2.8) ate Pfl01_3588 Pseudomonas fluorescens (strain Pf0-1) TR33806_c0_g2_i3 O95260 ATE1_HUMAN 8.00E-68 GO:0004057; GO:0005737; GO:0005634; GO:0016598 O43463 arginyltransferase activity; cytoplasm; nucleus; protein arginylation IPR016181; IPR017137; IPR007472; IPR007471; Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) ATE1 Homo sapiens (Human) TR33808_c3_g2_i1 Q09884 DCR1_SCHPO 1.00E-06 GO:0005524; GO:0016442; GO:0007049; GO:0034613; GO:0031048; GO:0007059; GO:0033562; GO:0005829; GO:0003690; GO:0003725; GO:0035389; GO:1990188; GO:0004386; GO:0031618; GO:0005719; GO:0034399; GO:0005643; GO:0030422; GO:0090052; GO:0051570; GO:0004525; GO:0004540; GO:0008270 ATP binding; RISC complex; cell cycle; cellular protein localization; chromatin silencing by small RNA; chromosome segregation; co-transcriptional gene silencing by RNA interference machinery; cytosol; double-stranded DNA binding; double-stranded RNA binding; establishment of chromatin silencing at silent mating-type cassette; euchromatin binding; helicase activity; nuclear centromeric heterochromatin; nuclear euchromatin; nuclear periphery; nuclear pore; production of siRNA involved in RNA interference; regulation of chromatin silencing at centromere; regulation of histone H3-K9 methylation; ribonuclease III activity; ribonuclease activity; zinc ion binding IPR005034; IPR006935; IPR014001; IPR001650; IPR027417; IPR000999; Protein Dicer (Cell cycle control protein dcr1) (RNA interference pathway protein dcr1) [Includes: Endoribonuclease dcr1 (EC 3.1.26.-); ATP-dependent helicase dcr1 (EC 3.6.4.-)] dcr1 SPCC188.13c SPCC584.10c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR33808_c3_g2_i2 Q9GLV6 DDX58_PIG 4.00E-20 GO:0005524; GO:0008026; GO:0039529; GO:0015629; GO:0005737; GO:0003725; GO:0045087; GO:0002230; GO:0032727; GO:0032728; GO:0030334; GO:0032587; GO:0003727; GO:0005923; GO:0008270 ATP binding; ATP-dependent helicase activity; RIG-I signaling pathway; actin cytoskeleton; cytoplasm; double-stranded RNA binding; innate immune response; positive regulation of defense response to virus by host; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; regulation of cell migration; ruffle membrane; single-stranded RNA binding; tight junction; zinc ion binding IPR011545; IPR014001; IPR001650; IPR027417; IPR021673; Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RHIV-1) (RIG-I-like receptor 1) (RLR-1) (RNA helicase induced by virus) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) DDX58 Sus scrofa (Pig) TR33808_c3_g3_i1 Q5A1A0 MPH1_CANAL 2.00E-06 GO:0005524; GO:0008026; GO:0003677; GO:0006281; GO:0005634 ATP binding; ATP-dependent helicase activity; DNA binding; DNA repair; nucleus IPR011545; IPR014001; IPR001650; IPR027417; ATP-dependent DNA helicase MPH1 (EC 3.6.4.12) MPH1 CaO19.10436 CaO19.2919 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) TR33808_c3_g3_i2 Q9GLV6 DDX58_PIG 3.00E-30 GO:0005524; GO:0008026; GO:0039529; GO:0015629; GO:0005737; GO:0003725; GO:0045087; GO:0002230; GO:0032727; GO:0032728; GO:0030334; GO:0032587; GO:0003727; GO:0005923; GO:0008270 ATP binding; ATP-dependent helicase activity; RIG-I signaling pathway; actin cytoskeleton; cytoplasm; double-stranded RNA binding; innate immune response; positive regulation of defense response to virus by host; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; regulation of cell migration; ruffle membrane; single-stranded RNA binding; tight junction; zinc ion binding IPR011545; IPR014001; IPR001650; IPR027417; IPR021673; Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RHIV-1) (RIG-I-like receptor 1) (RLR-1) (RNA helicase induced by virus) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) DDX58 Sus scrofa (Pig) TR33808_c4_g1_i3 Q96C10 DHX58_HUMAN 6.00E-23 GO:0005524; GO:0003677; GO:0005737; GO:0051607; GO:0003725; GO:0004386; GO:0045087; GO:0019048; GO:0039534; GO:0039536; GO:0045824; GO:0032480; GO:1900245; GO:1900246; GO:0032481; GO:0009615; GO:0003727; GO:0008270 Q9UKV8; Q7L2E3; Q9UPY3; P19525; P56537; O15226; P11207; P30927; Q9EMA9; Q9NUL3 ATP binding; DNA binding; cytoplasm; defense response to virus; double-stranded RNA binding; helicase activity; innate immune response; modulation by virus of host morphology or physiology; negative regulation of MDA-5 signaling pathway; negative regulation of RIG-I signaling pathway; negative regulation of innate immune response; negative regulation of type I interferon production; positive regulation of MDA-5 signaling pathway; positive regulation of RIG-I signaling pathway; positive regulation of type I interferon production; response to virus; single-stranded RNA binding; zinc ion binding IPR006935; IPR014001; IPR001650; IPR027417; IPR021673; Probable ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (Probable ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR) DHX58 D11LGP2E LGP2 Homo sapiens (Human) TR33809_c0_g1_i2 Q96MX6 WDR92_HUMAN 1.00E-93 GO:0006915; GO:0034968; GO:0035064 Q9H6T3 apoptotic process; histone lysine methylation; methylated histone residue binding IPR015943; IPR001680; IPR017986; WD repeat-containing protein 92 (WD repeat-containing protein Monad) WDR92 Homo sapiens (Human) TR33809_c0_g2_i1 Q54E33 WDR92_DICDI 2.00E-14 IPR015943; IPR001680; IPR017986; WD repeat-containing protein 92 homolog wdr92 DDB_G0291822 Dictyostelium discoideum (Slime mold) TR33811_c0_g1_i1 Q7RTX9 MOT14_HUMAN 1.00E-29 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR33811_c1_g1_i1 P52777 PALY_PINTA 2.00E-111 GO:0006559; GO:0009800; GO:0005737; GO:0045548 L-phenylalanine catabolic process; cinnamic acid biosynthetic process; cytoplasm; phenylalanine ammonia-lyase activity IPR001106; IPR024083; IPR008948; IPR022313; IPR005922; IPR023144; Phenylpropanoid metabolism; trans-cinnamate biosynthesis; trans-cinnamate from L-phenylalanine: step 1/1. Phenylalanine ammonia-lyase (EC 4.3.1.24) PAL Pinus taeda (Loblolly pine) TR33813_c2_g1_i1 Q9NPA5 ZF64A_HUMAN 3.00E-18 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; "Zinc finger protein 64 homolog, isoforms 1 and 2 (Zfp-64) (Zinc finger protein 338)" ZFP64 ZNF338 Homo sapiens (Human) TR33814_c0_g1_i1 Q5RGT6 ANGE2_DANRE 2.00E-93 IPR005135; Protein angel homolog 2 angel2 si:ch211-181h6.2 zgc:153829 Danio rerio (Zebrafish) (Brachydanio rerio) TR33814_c0_g1_i2 P31384 CCR4_YEAST 3.00E-23 GO:0000175; GO:0030015; GO:0000076; GO:0003723; GO:0000932; GO:0046872; GO:0000289; GO:0005634; GO:0004535; GO:0032968; GO:0048478; GO:0006368; GO:0007089 P53829; P25655; P34909; P39008 3'-5'-exoribonuclease activity; CCR4-NOT core complex; DNA replication checkpoint; RNA binding; cytoplasmic mRNA processing body; metal ion binding; nuclear-transcribed mRNA poly(A) tail shortening; nucleus; poly(A)-specific ribonuclease activity; positive regulation of transcription elongation from RNA polymerase II promoter; replication fork protection; transcription elongation from RNA polymerase II promoter; traversing start control point of mitotic cell cycle IPR005135; IPR001611; IPR025875; IPR003591; Glucose-repressible alcohol dehydrogenase transcriptional effector (EC 3.1.13.4) (Carbon catabolite repressor protein 4) (Cytoplasmic deadenylase) CCR4 YAL021C FUN27 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33815_c2_g1_i1 Q9JHE8 NINJ2_RAT 5.00E-08 GO:0007155; GO:0016021; GO:0042246 cell adhesion; integral to membrane; tissue regeneration IPR007007; Ninjurin-2 (Nerve injury-induced protein 2) Ninj2 Rattus norvegicus (Rat) TR33815_c2_g1_i2 Q92982 NINJ1_HUMAN 4.00E-06 GO:0007155; GO:0016021; GO:0007399; GO:0042246 cell adhesion; integral to membrane; nervous system development; tissue regeneration IPR007007; IPR015639; Ninjurin-1 (Nerve injury-induced protein 1) NINJ1 Homo sapiens (Human) TR33816_c1_g1_i6 Q1ZXD6 ROCO5_DICDI 3.00E-09 GO:0005524; GO:0005525; GO:0005089; GO:0005622; GO:0005543; GO:0004674; GO:0035023; GO:0007264; GO:0030587 ATP binding; GTP binding; Rho guanyl-nucleotide exchange factor activity; intracellular; phospholipid binding; protein serine/threonine kinase activity; regulation of Rho protein signal transduction; small GTPase mediated signal transduction; sorocarp development IPR000219; IPR011009; IPR001611; IPR025875; IPR003591; IPR013684; IPR027417; IPR011993; IPR001849; IPR000719; IPR017441; IPR020859; IPR001245; IPR008271; IPR001806; Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) TR33817_c5_g1_i1 Q9EQY6 PIGM_RAT 2.00E-128 GO:0006506; GO:0005789; GO:0016021; GO:0000030 GPI anchor biosynthetic process; endoplasmic reticulum membrane; integral to membrane; mannosyltransferase activity IPR007704; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. GPI mannosyltransferase 1 (EC 2.4.1.-) (GPI mannosyltransferase I) (GPI-MT-I) (Phosphatidylinositol-glycan biosynthesis class M protein) (PIG-M) Pigm Rattus norvegicus (Rat) TR33817_c5_g5_i1 B5DEI4 UBE2W_RAT 4.00E-83 GO:0005524; GO:0006281; GO:0071218; GO:0006515; GO:0005634; GO:0043161; GO:0006513; GO:0004842 ATP binding; DNA repair; cellular response to misfolded protein; misfolded or incompletely synthesized protein catabolic process; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein monoubiquitination; ubiquitin-protein ligase activity IPR000608; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 W (EC 6.3.2.19) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-protein ligase W) Ube2w Rattus norvegicus (Rat) TR33820_c0_g1_i1 Q09254 HAR1_CAEEL 1.00E-09 GO:0005739; GO:0055120 mitochondrion; striated muscle dense body IPR010625; Hemiasterlin resistant protein 1 har-1 C16C10.11 Caenorhabditis elegans TR33822_c1_g1_i3 H2A0M7 PLSP_PINMG 1.00E-58 GO:0005576; GO:0020037; GO:0004601; GO:0006979 extracellular region; heme binding; peroxidase activity; response to oxidative stress IPR010255; IPR002007; IPR019791; Peroxidase-like protein Pinctada margaritifera (Black-lipped pearl oyster) TR33825_c0_g2_i1 Q555N7 ZDHC4_DICDI 1.00E-12 GO:0016021; GO:0016746; GO:0008270 "integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Putative ZDHHC-type palmitoyltransferase 4 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 4) DDB_G0274251 Dictyostelium discoideum (Slime mold) TR33828_c0_g1_i1 Q64441 CP24A_MOUSE 4.00E-95 GO:0030342; GO:0008403; GO:0020037; GO:0005506; GO:0005739; GO:0001649; GO:0033280; GO:0042359 "1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; heme binding; iron ion binding; mitochondrion; osteoblast differentiation; response to vitamin D; vitamin D metabolic process" IPR001128; IPR017972; IPR002401; "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.13.126) (Cytochrome P450 24A1) (Cytochrome P450-CC24)" Cyp24a1 Cyp-24 Cyp24 Mus musculus (Mouse) TR33828_c0_g1_i4 G4XV71 C93C2_GLYUR 9.00E-25 GO:0033770; GO:0005783; GO:0020037; GO:0016021; GO:0043231; GO:0005506; GO:0009717; GO:0031090 2-hydroxyisoflavanone synthase activity; endoplasmic reticulum; heme binding; integral to membrane; intracellular membrane-bounded organelle; iron ion binding; isoflavonoid biosynthetic process; organelle membrane IPR001128; IPR017972; IPR002401; 2-hydroxyisoflavanone synthase (2HI synthase) (EC 1.14.13.136) (Cytochrome P450 93C2) (Isoflavonoid synthase) CYP93C2 IFS1 IFS2 Glycyrrhiza uralensis (Chinese licorice) (Glycyrrhiza shiheziensis) TR33828_c0_g1_i5 Q64441 CP24A_MOUSE 8.00E-95 GO:0030342; GO:0008403; GO:0020037; GO:0005506; GO:0005739; GO:0001649; GO:0033280; GO:0042359 "1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; heme binding; iron ion binding; mitochondrion; osteoblast differentiation; response to vitamin D; vitamin D metabolic process" IPR001128; IPR017972; IPR002401; "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.13.126) (Cytochrome P450 24A1) (Cytochrome P450-CC24)" Cyp24a1 Cyp-24 Cyp24 Mus musculus (Mouse) TR33829_c0_g2_i1 Q15386 UBE3C_HUMAN 0 GO:0005737; GO:0005634; GO:0000502; GO:0000209; GO:0042787; GO:0004842 cytoplasm; nucleus; proteasome complex; protein polyubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000569; IPR000048; Protein modification; protein ubiquitination. Ubiquitin-protein ligase E3C (EC 6.3.2.-) (HectH2) UBE3C KIAA0010 KIAA10 Homo sapiens (Human) TR33829_c0_g2_i2 Q15386 UBE3C_HUMAN 0 GO:0005737; GO:0005634; GO:0000502; GO:0000209; GO:0042787; GO:0004842 cytoplasm; nucleus; proteasome complex; protein polyubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000569; IPR000048; Protein modification; protein ubiquitination. Ubiquitin-protein ligase E3C (EC 6.3.2.-) (HectH2) UBE3C KIAA0010 KIAA10 Homo sapiens (Human) TR33832_c7_g1_i1 Q92805 GOGA1_HUMAN 1.00E-24 GO:0005794; GO:0032580; GO:0048471; GO:0000042; GO:0005802 Golgi apparatus; Golgi cisterna membrane; perinuclear region of cytoplasm; protein targeting to Golgi; trans-Golgi network IPR000237; Golgin subfamily A member 1 (Golgin-97) GOLGA1 Homo sapiens (Human) TR33833_c1_g1_i1 P46782 RS5_HUMAN 2.00E-131 GO:0006614; GO:0022627; GO:0003729; GO:0000184; GO:0006450; GO:0003735; GO:0006414; GO:0006413; GO:0006415; GO:0019083 "SRP-dependent cotranslational protein targeting to membrane; cytosolic small ribosomal subunit; mRNA binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; regulation of translational fidelity; structural constituent of ribosome; translational elongation; translational initiation; translational termination; viral transcription" IPR000235; IPR005716; IPR020606; IPR023798; "40S ribosomal protein S5 [Cleaved into: 40S ribosomal protein S5, N-terminally processed]" RPS5 Homo sapiens (Human) TR33833_c3_g1_i1 P62315 SMD1_MOUSE 7.00E-36 GO:0008380; GO:0005689; GO:0071013; GO:0005737; GO:0006397; GO:0005634 RNA splicing; U12-type spliceosomal complex; catalytic step 2 spliceosome; cytoplasm; mRNA processing; nucleus IPR027141; IPR010920; IPR001163; IPR006649; Small nuclear ribonucleoprotein Sm D1 (Sm-D1) (Sm-D autoantigen) (snRNP core protein D1) Snrpd1 Mus musculus (Mouse) TR33835_c9_g1_i1 O92815 POL_WDSV 5.00E-11 GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0020002; GO:0016020; GO:0090305; GO:0006508; GO:0004523; GO:0039660; GO:0019013; GO:0008270 DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; host cell plasma membrane; membrane; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; structural constituent of virion; viral nucleocapsid; zinc ion binding IPR001584; IPR018061; IPR021109; IPR012337; IPR002156; IPR000477; IPR001878; Gag-Pol polyprotein [Cleaved into: Matrix protein p10 (MA); p20; Capsid protein p25 (CA); Nucleocapsid protein p14 (NC-pol); Protease p15 (PR) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H p90 (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase p46 (IN)] gag-pol Walleye dermal sarcoma virus (WDSV) TR33836_c3_g2_i1 Q68F60 CUE2B_XENLA 3.00E-15 GO:0005737; GO:0005634 cytoplasm; nucleus CUE domain-containing protein 2-B cuedc2-b Xenopus laevis (African clawed frog) TR33836_c3_g2_i6 Q68F60 CUE2B_XENLA 4.00E-09 GO:0005737; GO:0005634 cytoplasm; nucleus CUE domain-containing protein 2-B cuedc2-b Xenopus laevis (African clawed frog) TR33839_c1_g2_i3 Q9H1P6 CT085_HUMAN 3.00E-24 IPR020339; Uncharacterized protein C20orf85 C20orf85 Homo sapiens (Human) TR33841_c2_g2_i2 Q9VCR6 SAV_DROME 1.00E-17 GO:0072002; GO:0045464; GO:0005912; GO:0006915; GO:0005737; GO:0035329; GO:0007444; GO:0008285; GO:0046621; GO:0043065; GO:0048814; GO:0045570; GO:0040014; GO:0010212; GO:0046666; GO:0048863; GO:0072089 Malpighian tubule development; R8 cell fate specification; adherens junction; apoptotic process; cytoplasm; hippo signaling cascade; imaginal disc development; negative regulation of cell proliferation; negative regulation of organ growth; positive regulation of apoptotic process; regulation of dendrite morphogenesis; regulation of imaginal disc growth; regulation of multicellular organism growth; response to ionizing radiation; retinal cell programmed cell death; stem cell differentiation; stem cell proliferation IPR011524; IPR001202; Scaffold protein salvador (Shar-pei) sav SHRP CG33193 Drosophila melanogaster (Fruit fly) TR33841_c2_g2_i3 Q8VEB2 SAV1_MOUSE 1.00E-22 GO:0005737; GO:0001942; GO:0035329; GO:0060575; GO:0030216; GO:0060487; GO:0060044; GO:0050680; GO:0005634; GO:0043065; GO:2000036; GO:0060412 cytoplasm; hair follicle development; hippo signaling cascade; intestinal epithelial cell differentiation; keratinocyte differentiation; lung epithelial cell differentiation; negative regulation of cardiac muscle cell proliferation; negative regulation of epithelial cell proliferation; nucleus; positive regulation of apoptotic process; regulation of stem cell maintenance; ventricular septum morphogenesis IPR011524; IPR001202; Protein salvador homolog 1 (45 kDa WW domain protein) (mWW45) Sav1 Ww45 Wwp3 Mus musculus (Mouse) TR33843_c0_g1_i1 Q01713 KLF9_RAT 4.00E-47 GO:0003677; GO:1901653; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cellular response to peptide; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Krueppel-like factor 9 (Basic transcription element-binding protein 1) (BTE-binding protein 1) (GC-box-binding protein 1) (Transcription factor BTEB1) Klf9 Bteb Bteb1 Rattus norvegicus (Rat) TR33847_c2_g1_i1 Q94516 AT5F1_DROME 1.00E-41 GO:0015986; GO:0005811; GO:0000276; GO:0006909; GO:0046933 "ATP synthesis coupled proton transport; lipid particle; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); phagocytosis; proton-transporting ATP synthase activity, rotational mechanism" IPR008688; IPR013837; "ATP synthase subunit b, mitochondrial (ATPase subunit b) (FO-ATP synthase subunit b)" ATPsyn-b ATPsyn-beta CG8189 Drosophila melanogaster (Fruit fly) TR33848_c0_g1_i2 Q28DG7 UBAC1_XENTR 2.00E-37 GO:0005737; GO:0016567 cytoplasm; protein ubiquitination IPR006636; IPR009060; IPR015940; IPR000449; IPR000626; Protein modification; protein ubiquitination. Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (E3 ubiquitin-protein ligase subunit KPC2) (Kip1 ubiquitination-promoting complex protein 2) ubac1 kpc2 ubadc1 TEgg011a06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33849_c0_g1_i1 Q96J87 CELF6_HUMAN 8.00E-07 GO:0003723; GO:0005737; GO:0006397; GO:0000166; GO:0005634; GO:0000381 "RNA binding; cytoplasm; mRNA processing; nucleotide binding; nucleus; regulation of alternative mRNA splicing, via spliceosome" IPR012677; IPR000504; CUGBP Elav-like family member 6 (CELF-6) (Bruno-like protein 6) (CUG-BP- and ETR-3-like factor 6) (RNA-binding protein BRUNOL-6) CELF6 BRUNOL6 Homo sapiens (Human) TR33849_c0_g1_i2 O43347 MSI1H_HUMAN 3.00E-33 GO:0003723; GO:0005737; GO:0030855; GO:0007399; GO:0000166; GO:0005634; GO:0008266; GO:0005844; GO:0009725 RNA binding; cytoplasm; epithelial cell differentiation; nervous system development; nucleotide binding; nucleus; poly(U) RNA binding; polysome; response to hormone stimulus IPR012677; IPR000504; RNA-binding protein Musashi homolog 1 (Musashi-1) MSI1 Homo sapiens (Human) TR33849_c0_g1_i3 P07909 ROA1_DROME 8.00E-59 GO:0036099; GO:0048027; GO:0033119; GO:0000166; GO:0005634; GO:0048477; GO:0005703; GO:0045727; GO:0000381; GO:0030529; GO:0043565 "female germ-line stem cell maintenance; mRNA 5'-UTR binding; negative regulation of RNA splicing; nucleotide binding; nucleus; oogenesis; polytene chromosome puff; positive regulation of translation; regulation of alternative mRNA splicing, via spliceosome; ribonucleoprotein complex; sequence-specific DNA binding" IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (PEN repeat clone P9) (hnRNP core protein A1-A) Hrb98DE Pen9 CG9983 Drosophila melanogaster (Fruit fly) TR33849_c0_g1_i4 P07909 ROA1_DROME 4.00E-60 GO:0036099; GO:0048027; GO:0033119; GO:0000166; GO:0005634; GO:0048477; GO:0005703; GO:0045727; GO:0000381; GO:0030529; GO:0043565 "female germ-line stem cell maintenance; mRNA 5'-UTR binding; negative regulation of RNA splicing; nucleotide binding; nucleus; oogenesis; polytene chromosome puff; positive regulation of translation; regulation of alternative mRNA splicing, via spliceosome; ribonucleoprotein complex; sequence-specific DNA binding" IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (PEN repeat clone P9) (hnRNP core protein A1-A) Hrb98DE Pen9 CG9983 Drosophila melanogaster (Fruit fly) TR33850_c0_g1_i3 Q6INU7 FRRS1_XENLA 1.00E-36 GO:0016021; GO:0016491 integral to membrane; oxidoreductase activity IPR006593; IPR005018; IPR002861; Putative ferric-chelate reductase 1 (EC 1.-.-.-) frrs1 Xenopus laevis (African clawed frog) TR33850_c0_g2_i2 Q9P0K9 FRS1L_HUMAN 6.00E-10 GO:0030054; GO:0016021; GO:0005886; GO:0045202 cell junction; integral to membrane; plasma membrane; synapse IPR005018; DOMON domain-containing protein FRRS1L (Brain protein CG-6) (Ferric-chelate reductase 1-like protein) FRRS1L C9orf4 Homo sapiens (Human) TR33851_c0_g3_i2 Q67FQ3 ARHB_XENLA 2.00E-43 GO:0008203; GO:0005737; GO:0006897 cholesterol metabolic process; cytoplasm; endocytosis IPR011993; IPR006020; Low density lipoprotein receptor adapter protein 1-B (Autosomal recessive hypercholesterolemia protein homolog beta) (ARH beta) (xARH beta) ldlrap1-b Xenopus laevis (African clawed frog) TR33852_c1_g1_i1 Q9HDD0 HRSL1_HUMAN 6.00E-20 GO:0046485; GO:0016021; GO:0016042; GO:0005641; GO:0005777; GO:0007031; GO:0004620; GO:0016740 ether lipid metabolic process; integral to membrane; lipid catabolic process; nuclear envelope lumen; peroxisome; peroxisome organization; phospholipase activity; transferase activity IPR007053; Phospholipid-metabolizing enzyme A-C1 (EC 2.3.1.-) (EC 3.1.1.-) (HRAS-like suppressor 1) (HRSL1) HRASLS Homo sapiens (Human) TR33852_c1_g1_i3 P53817 PAG16_RAT 1.00E-17 GO:0052740; GO:0005737; GO:0005783; GO:0016021; GO:0016042; GO:0016020; GO:0045786; GO:0048471; GO:0008970; GO:0052739; GO:0004623; GO:0008654 1-acyl-2-lysophosphatidylserine acylhydrolase activity; cytoplasm; endoplasmic reticulum; integral to membrane; lipid catabolic process; membrane; negative regulation of cell cycle; perinuclear region of cytoplasm; phosphatidylcholine 1-acylhydrolase activity; phosphatidylserine 1-acylhydrolase activity; phospholipase A2 activity; phospholipid biosynthetic process IPR007053; HRAS-like suppressor 3 (HRSL3) (EC 3.1.1.32) (EC 3.1.1.4) (Group XVI phospholipase A1/A2) (H-rev 107 protein) Pla2g16 H-rev107 Hrasls3 Hrev107 Rattus norvegicus (Rat) TR33853_c1_g1_i1 Q6ING7 FLAD1_XENLA 2.00E-175 GO:0005524; GO:0006747; GO:0003919; GO:0006777 ATP binding; FAD biosynthetic process; FMN adenylyltransferase activity; Mo-molybdopterin cofactor biosynthetic process IPR012183; IPR001453; IPR002500; IPR014729; Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1. FAD synthase (EC 2.7.7.2) (FAD pyrophosphorylase) (FMN adenylyltransferase) (Flavin adenine dinucleotide synthase) [Includes: Molybdenum cofactor biosynthesis protein-like region; FAD synthase region] flad1 Xenopus laevis (African clawed frog) TR33853_c1_g1_i4 Q6ING7 FLAD1_XENLA 1.00E-171 GO:0005524; GO:0006747; GO:0003919; GO:0006777 ATP binding; FAD biosynthetic process; FMN adenylyltransferase activity; Mo-molybdopterin cofactor biosynthetic process IPR012183; IPR001453; IPR002500; IPR014729; Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1. FAD synthase (EC 2.7.7.2) (FAD pyrophosphorylase) (FMN adenylyltransferase) (Flavin adenine dinucleotide synthase) [Includes: Molybdenum cofactor biosynthesis protein-like region; FAD synthase region] flad1 Xenopus laevis (African clawed frog) TR33853_c1_g1_i5 O28033 Y2251_ARCFU 4.00E-26 GO:0006777 Mo-molybdopterin cofactor biosynthetic process IPR020817; IPR023055; IPR001453; Protein AF_2251 AF_2251 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) TR33853_c1_g1_i6 Q2S304 CINAL_SALRD 2.00E-16 GO:0006777 Mo-molybdopterin cofactor biosynthetic process IPR008136; IPR008135; IPR001453; CinA-like protein SRU_1303 Salinibacter ruber (strain DSM 13855 / M31) TR33854_c2_g2_i1 P34269 TYR1_CAEEL 9.00E-08 GO:0046872; GO:0004497 metal ion binding; monooxygenase activity IPR003582; IPR002227; IPR008922; Putative tyrosinase-like protein tyr-1 tyr-1 C02C2.1/C02C2.2 Caenorhabditis elegans TR33854_c2_g5_i1 Q7T141 PI15A_DANRE 8.00E-22 GO:0005576; GO:0030414 extracellular region; peptidase inhibitor activity IPR001283; IPR018244; IPR014044; Peptidase inhibitor 15-A pi15a pi15 si:rp71-1m12.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR33854_c2_g5_i3 Q7T141 PI15A_DANRE 6.00E-23 GO:0005576; GO:0030414 extracellular region; peptidase inhibitor activity IPR001283; IPR018244; IPR014044; Peptidase inhibitor 15-A pi15a pi15 si:rp71-1m12.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR33855_c0_g1_i2 Q3SZZ2 XBP1_BOVIN 3.00E-24 GO:0060691; GO:0031017; GO:0005634; GO:1900103; GO:0043565; GO:0003700; GO:0006351 "epithelial cell maturation involved in salivary gland development; exocrine pancreas development; nucleus; positive regulation of endoplasmic reticulum unfolded protein response; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; X-box-binding protein 1 (XBP-1) XBP1 Bos taurus (Bovine) TR33856_c0_g1_i1 Q5R723 PPIE_PONAB 8.00E-157 GO:0003723; GO:0008380; GO:0006397; GO:0000166; GO:0003755; GO:0006457; GO:0000413; GO:0005681 RNA binding; RNA splicing; mRNA processing; nucleotide binding; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization; spliceosomal complex IPR002130; IPR020892; IPR016304; IPR012677; IPR000504; Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Rotamase E) PPIE Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33857_c1_g1_i2 Q8TDP1 RNH2C_HUMAN 1.00E-15 GO:0006401; GO:0005634; GO:0032299 RNA catabolic process; nucleus; ribonuclease H2 complex IPR013924; Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C) RNASEH2C AYP1 Homo sapiens (Human) TR33858_c0_g1_i1 Q9CR42 ANKR1_MOUSE 3.00E-12 GO:0003677; GO:0031674; GO:0001105; GO:0055008; GO:0035690; GO:0071456; GO:0071347; GO:0071222; GO:0071260; GO:0071407; GO:0071560; GO:0071356; GO:0005829; GO:2000279; GO:0000122; GO:0005634; GO:0043517; GO:0043065; GO:0010976; GO:0050714; GO:0006357; GO:0035994; GO:0035914; GO:0003714; GO:0005667 "DNA binding; I band; RNA polymerase II transcription coactivator activity; cardiac muscle tissue morphogenesis; cellular response to drug; cellular response to hypoxia; cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to organic cyclic compound; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; cytosol; negative regulation of DNA biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of apoptotic process; positive regulation of neuron projection development; positive regulation of protein secretion; regulation of transcription from RNA polymerase II promoter; response to muscle stretch; skeletal muscle cell differentiation; transcription corepressor activity; transcription factor complex" IPR002110; IPR020683; Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) Ankrd1 Carp Mus musculus (Mouse) TR33861_c0_g1_i1 Q8C525 M21D2_MOUSE 3.00E-10 IPR024810; IPR024803; Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) TR33862_c2_g1_i1 P56719 OX2R_RAT 2.00E-17 GO:0022410; GO:0007631; GO:0016021; GO:0007218; GO:0016499; GO:0017046; GO:0007200; GO:0005886 circadian sleep/wake cycle process; feeding behavior; integral to membrane; neuropeptide signaling pathway; orexin receptor activity; peptide hormone binding; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane IPR000276; IPR017452; IPR000204; IPR004060; Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Rattus norvegicus (Rat) TR33862_c2_g1_i2 Q24563 DOPR2_DROME 6.00E-09 GO:0008227; GO:0007191; GO:0004935; GO:0071875; GO:0001588; GO:0005887; GO:0030285 "G-protein coupled amine receptor activity; adenylate cyclase-activating dopamine receptor signaling pathway; adrenergic receptor activity; adrenergic receptor signaling pathway; dopamine neurotransmitter receptor activity, coupled via Gs; integral to plasma membrane; integral to synaptic vesicle membrane" IPR002233; IPR000276; IPR017452; Dopamine receptor 2 DopR2 DAMB DopR99B CG18741 Drosophila melanogaster (Fruit fly) TR33863_c0_g1_i1 O60921 HUS1_HUMAN 4.00E-81 GO:0000077; GO:0006281; GO:0006260; GO:0005794; GO:0071479; GO:0030896; GO:0000724; GO:0009790; GO:0007093; GO:0008156; GO:0005730; GO:0005654; GO:0006468; GO:0001932; GO:0009411 O60671; Q99638 DNA damage checkpoint; DNA repair; DNA replication; Golgi apparatus; cellular response to ionizing radiation; checkpoint clamp complex; double-strand break repair via homologous recombination; embryo development; mitotic cell cycle checkpoint; negative regulation of DNA replication; nucleolus; nucleoplasm; protein phosphorylation; regulation of protein phosphorylation; response to UV IPR016580; IPR007150; Checkpoint protein HUS1 (hHUS1) HUS1 Homo sapiens (Human) TR33864_c0_g1_i2 Q5RJ80 CAPR2_DANRE 2.00E-07 GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:2000055; GO:0090263; GO:0050775; GO:0061003; GO:0040008 RNA binding; cytoplasm; dorsal/ventral pattern formation; negative regulation of translation; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of dendrite morphogenesis; positive regulation of dendritic spine morphogenesis; regulation of growth IPR001073; IPR008983; Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR33864_c0_g1_i4 P83425 HIP_MYTED 2.00E-08 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR33865_c0_g1_i1 Q921I2 KLDC4_MOUSE 2.00E-135 IPR015915; IPR011498; Kelch domain-containing protein 4 Klhdc4 Mus musculus (Mouse) TR33866_c0_g3_i1 A6H8I2 SGSM3_XENLA 2.00E-26 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; IPR004012; IPR001452; Small G protein signaling modulator 3 homolog (RUN and TBC1 domain-containing protein 3) sgsm3 rutbc3 Xenopus laevis (African clawed frog) TR33868_c0_g2_i1 Q5BK43 ESIP1_RAT 1.00E-09 IPR026185; Epithelial-stromal interaction protein 1 Epsti1 Rattus norvegicus (Rat) TR33869_c2_g1_i1 Q96RW7 HMCN1_HUMAN 3.00E-154 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR33870_c2_g1_i2 P30028 DPOL_HPBDC 2.00E-07 GO:0003677; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0046872; GO:0090305; GO:0004523 DNA binding; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; ribonuclease H activity IPR001462; IPR000201; IPR000477; Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4)] P Duck hepatitis B virus (strain China) (DHBV) TR33874_c5_g1_i2 Q9TU53 CUBN_CANFA 7.00E-06 GO:0005509; GO:0008203; GO:0031419; GO:0010008; GO:0005765; GO:0015031 calcium ion binding; cholesterol metabolic process; cobalamin binding; endosome membrane; lysosomal membrane; protein transport IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR009030; Cubilin CUBN Canis familiaris (Dog) (Canis lupus familiaris) TR33874_c5_g1_i3 Q9JLB4 CUBN_MOUSE 2.00E-07 GO:0005794; GO:0016324; GO:0005903; GO:0005509; GO:0008203; GO:0005905; GO:0031419; GO:0030139; GO:0005783; GO:0005768; GO:0010008; GO:0042953; GO:0005765; GO:0004872; GO:0006898 Golgi apparatus; apical plasma membrane; brush border; calcium ion binding; cholesterol metabolic process; coated pit; cobalamin binding; endocytic vesicle; endoplasmic reticulum; endosome; endosome membrane; lipoprotein transport; lysosomal membrane; receptor activity; receptor-mediated endocytosis IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; Cubilin (Intrinsic factor-cobalamin receptor) Cubn Ifcr Mus musculus (Mouse) TR33874_c7_g1_i1 O88307 SORL_MOUSE 6.00E-06 GO:0005794; GO:0008203; GO:0006897; GO:0005768; GO:0016021; GO:0006869; GO:0034362; GO:0030169; GO:0007275; GO:0048471 Golgi apparatus; cholesterol metabolic process; endocytosis; endosome; integral to membrane; lipid transport; low-density lipoprotein particle; low-density lipoprotein particle binding; multicellular organismal development; perinuclear region of cytoplasm IPR011042; IPR003961; IPR013783; IPR023415; IPR000033; IPR002172; IPR006581; Sortilin-related receptor (Gp250) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) Sorl1 Mus musculus (Mouse) TR33876_c0_g1_i5 Q9H9H4 VP37B_HUMAN 4.00E-25 GO:0000813; GO:0016197; GO:0031902; GO:0030496; GO:0015031; GO:0019082; GO:0019068 ESCRT I complex; endosomal transport; late endosome membrane; midbody; protein transport; viral protein processing; virion assembly IPR009851; Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B) VPS37B Homo sapiens (Human) TR33877_c1_g1_i2 Q575T0 CYGB1_ORYLA 2.00E-11 GO:0005737; GO:0020037; GO:0005506; GO:0019825; GO:0005344 cytoplasm; heme binding; iron ion binding; oxygen binding; oxygen transporter activity IPR000971; IPR009050; IPR012292; IPR013314; Cytoglobin-1 cygb1 cygb-1 Oryzias latipes (Medaka fish) (Japanese ricefish) TR33877_c1_g1_i3 P23741 HBB_LATCH 2.00E-07 GO:0020037; GO:0005833; GO:0005506; GO:0019825; GO:0005344 heme binding; hemoglobin complex; iron ion binding; oxygen binding; oxygen transporter activity IPR000971; IPR009050; IPR012292; IPR002337; Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) HBB Latimeria chalumnae (West Indian ocean coelacanth) TR33878_c0_g1_i1 P04634 LIPG_RAT 6.00E-125 GO:0007586; GO:0005576; GO:0016298; GO:0016042; GO:0016615; GO:0006108; GO:0005739; GO:0004806 digestion; extracellular region; lipase activity; lipid catabolic process; malate dehydrogenase activity; malate metabolic process; mitochondrion; triglyceride lipase activity IPR000073; IPR006693; IPR025483; Gastric triacylglycerol lipase (GL) (Gastric lipase) (EC 3.1.1.3) (Lingual lipase) Lipf Rattus norvegicus (Rat) TR33883_c0_g1_i3 D3ZAT9 FAXC_RAT 8.00E-55 GO:0016021 integral to membrane IPR026928; IPR010987; IPR012336; Failed axon connections homolog Faxc Rattus norvegicus (Rat) TR33884_c0_g1_i2 P81893 L2AM_DROSI 7.00E-19 GO:0016831; GO:0006584; GO:0006520; GO:0040003; GO:0030170; GO:0042302 carboxy-lyase activity; catecholamine metabolic process; cellular amino acid metabolic process; chitin-based cuticle development; pyridoxal phosphate binding; structural constituent of cuticle IPR010977; IPR002129; IPR015424; IPR015421; IPR015422; IPR021115; Alpha-methyldopa hypersensitive protein (EC 4.1.1.-) (Fragment) amd Drosophila simulans (Fruit fly) TR33884_c0_g1_i4 Q9Y600 CSAD_HUMAN 1.00E-166 GO:0034641; GO:0030170; GO:0004782; GO:0000098; GO:0042412 cellular nitrogen compound metabolic process; pyridoxal phosphate binding; sulfinoalanine decarboxylase activity; sulfur amino acid catabolic process; taurine biosynthetic process IPR002129; IPR015424; IPR015421; IPR015422; Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 2/2. Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase) CSAD CSD Homo sapiens (Human) TR33885_c2_g1_i4 Q95332 BHMT1_PIG 1.00E-34 GO:0006579; GO:0047150; GO:0005737; GO:0008898; GO:0009086; GO:0008270 amino-acid betaine catabolic process; betaine-homocysteine S-methyltransferase activity; cytoplasm; homocysteine S-methyltransferase activity; methionine biosynthetic process; zinc ion binding IPR017226; IPR003726; Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. Betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5) (Fragment) BHMT Sus scrofa (Pig) TR33885_c2_g1_i5 O35490 BHMT1_MOUSE 1.00E-45 GO:0006579; GO:0047150; GO:0005737; GO:0008898; GO:0009086; GO:0008270 amino-acid betaine catabolic process; betaine-homocysteine S-methyltransferase activity; cytoplasm; homocysteine S-methyltransferase activity; methionine biosynthetic process; zinc ion binding IPR017226; IPR003726; Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. Betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5) Bhmt Mus musculus (Mouse) TR33887_c3_g1_i4 O73746 TIMP3_XENLA 3.00E-07 GO:0046872; GO:0008191; GO:0005578 metal ion binding; metalloendopeptidase inhibitor activity; proteinaceous extracellular matrix IPR001134; IPR001820; IPR008993; IPR027465; IPR015612; Metalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) (TIMP-3) timp3 Xenopus laevis (African clawed frog) TR33888_c0_g1_i1 Q6P3W7 SCYL2_HUMAN 4.00E-129 GO:0005524; GO:0005794; GO:0030136; GO:0010008; GO:0008333; GO:0090090; GO:0048471; GO:2000370; GO:0002092; GO:0004672; GO:2000286 ATP binding; Golgi apparatus; clathrin-coated vesicle; endosome membrane; endosome to lysosome transport; negative regulation of canonical Wnt receptor signaling pathway; perinuclear region of cytoplasm; positive regulation of clathrin-mediated endocytosis; positive regulation of receptor internalization; protein kinase activity; receptor internalization involved in canonical Wnt receptor signaling pathway IPR011989; IPR016024; IPR011009; IPR000719; SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa) SCYL2 CVAK104 KIAA1360 Homo sapiens (Human) TR33888_c0_g1_i2 Q54PX0 Y4251_DICDI 2.00E-06 GO:0005524; GO:0046872; GO:0004674 ATP binding; metal ion binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR001245; IPR002290; IPR008271; Probable serine/threonine-protein kinase DDB_G0284251 (EC 2.7.11.1) DDB_G0284251 Dictyostelium discoideum (Slime mold) TR33890_c0_g1_i1 P50225 ST1A1_HUMAN 8.00E-39 GO:0050427; GO:0009308; GO:0004062; GO:0006584; GO:0005829; GO:0008210; GO:0009812; GO:0047894; GO:0050294; GO:0051923; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; amine metabolic process; aryl sulfotransferase activity; catecholamine metabolic process; cytosol; estrogen metabolic process; flavonoid metabolic process; flavonol 3-sulfotransferase activity; steroid sulfotransferase activity; sulfation; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST 1) (ST1A3) (Thermostable phenol sulfotransferase) (Ts-PST) SULT1A1 STP STP1 OK/SW-cl.88 Homo sapiens (Human) TR33890_c0_g1_i2 Q95JD5 ST1B1_CANFA 2.00E-50 GO:0004062; GO:0005737; GO:0009812; GO:0008202; GO:0051923; GO:0042403; GO:0006805 aryl sulfotransferase activity; cytoplasm; flavonoid metabolic process; steroid metabolic process; sulfation; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (cSULT1B1) (EC 2.8.2.-) SULT1B1 ST1B2 Canis familiaris (Dog) (Canis lupus familiaris) TR33890_c0_g1_i4 O43704 ST1B1_HUMAN 4.00E-48 GO:0050427; GO:0004062; GO:0006576; GO:0005829; GO:0009812; GO:0008202; GO:0051923; GO:0008146; GO:0042403; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; aryl sulfotransferase activity; cellular biogenic amine metabolic process; cytosol; flavonoid metabolic process; steroid metabolic process; sulfation; sulfotransferase activity; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) (Sulfotransferase 1B2) (ST1B2) (Thyroid hormone sulfotransferase) SULT1B1 ST1B2 SULT1B2 Homo sapiens (Human) TR33890_c0_g1_i5 O75897 ST1C4_HUMAN 3.00E-49 GO:0050427; GO:0005829; GO:0051923; GO:0008146; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; cytosol; sulfation; sulfotransferase activity; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.-) (Sulfotransferase 1C2) (SULT1C#2) SULT1C4 SULT1C2 Homo sapiens (Human) TR33892_c1_g4_i1 P61759 PFD3_MOUSE 3.00E-44 GO:0005737; GO:0005634; GO:0016272; GO:0006457 cytoplasm; nucleus; prefoldin complex; protein folding IPR009053; IPR016655; IPR004127; Prefoldin subunit 3 (Von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1) Vbp1 Pfdn3 Mus musculus (Mouse) TR33892_c1_g4_i2 P57741 PFD3_ARATH 4.00E-24 GO:0005829; GO:0016272; GO:0006457 cytosol; prefoldin complex; protein folding IPR009053; IPR016655; IPR004127; Probable prefoldin subunit 3 At5g49510 K6M13.5 Arabidopsis thaliana (Mouse-ear cress) TR33894_c2_g1_i1 Q14653 IRF3_HUMAN 4.00E-09 GO:0003677; GO:0039530; GO:0035666; GO:0071359; GO:0005829; GO:0060333; GO:0031663; GO:0071888; GO:0019048; GO:0050689; GO:0045358; GO:0000122; GO:0032480; GO:0005654; GO:0043123; GO:0050715; GO:0032727; GO:0032728; GO:0060340; GO:0006974; GO:0043330; GO:0003700; GO:0034138; GO:0034142; GO:0003712; GO:0006366; GO:0044212; GO:0045351; GO:0060337 Itself; Q92793; Q9Y3R0; Q9Y5Q3; P06400; P28749; O43765; Q9UHD2 DNA binding; MDA-5 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; cellular response to dsRNA; cytosol; interferon-gamma-mediated signaling pathway; lipopolysaccharide-mediated signaling pathway; macrophage apoptotic process; modulation by virus of host morphology or physiology; negative regulation of defense response to virus by host; negative regulation of interferon-beta biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of type I interferon production; nucleoplasm; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of cytokine secretion; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of type I interferon-mediated signaling pathway; response to DNA damage stimulus; response to exogenous dsRNA; sequence-specific DNA binding transcription factor activity; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; transcription cofactor activity; transcription from RNA polymerase II promoter; transcription regulatory region DNA binding; type I interferon biosynthetic process; type I interferon-mediated signaling pathway IPR019817; IPR001346; IPR019471; IPR017855; IPR008984; IPR011991; Interferon regulatory factor 3 (IRF-3) IRF3 Homo sapiens (Human) TR33894_c2_g1_i2 Q8R4E0 IRF2_SIGHI 1.00E-33 GO:0005634; GO:0000975; GO:0003700; GO:0006351 "nucleus; regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017431; IPR019817; IPR001346; IPR011991; Interferon regulatory factor 2 (IRF-2) IRF2 Sigmodon hispidus (Hispid cotton rat) TR33895_c0_g1_i1 Q15024 EXOS7_HUMAN 7.00E-77 GO:0000175; GO:0003723; GO:0005829; GO:0043928; GO:0000178; GO:0005730; GO:0006364 Q9Y3B2; Q13868 3'-5'-exoribonuclease activity; RNA binding; cytosol; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; exosome (RNase complex); nucleolus; rRNA processing IPR001247; IPR015847; IPR027408; IPR020568; Exosome complex component RRP42 (Exosome component 7) (Ribosomal RNA-processing protein 42) (p8) EXOSC7 KIAA0116 RRP42 Homo sapiens (Human) TR33896_c1_g1_i4 P40190 IL6RB_RAT 2.00E-07 GO:0016021; GO:0019981; GO:0004915; GO:0032809; GO:0014911; GO:0046982; GO:0051481; GO:0046883; GO:0007584; GO:0006642 integral to membrane; interleukin-6 binding; interleukin-6 receptor activity; neuronal cell body membrane; positive regulation of smooth muscle cell migration; protein heterodimerization activity; reduction of cytosolic calcium ion concentration; regulation of hormone secretion; response to nutrient; triglyceride mobilization IPR003961; IPR003529; IPR013783; IPR010457; Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130) Il6st Rattus norvegicus (Rat) TR33897_c0_g1_i3 P43620 RMD8_YEAST 3.00E-17 GO:0016021; GO:0007126; GO:0030435 integral to membrane; meiosis; sporulation resulting in formation of a cellular spore IPR003734; Sporulation protein RMD8 (Required for meiotic nuclear division protein 8) RMD8 YFR048W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33897_c0_g1_i4 Q9NWS8 RMND1_HUMAN 2.00E-35 GO:0005739; GO:0006412 mitochondrion; translation IPR003734; Required for meiotic nuclear division protein 1 homolog RMND1 C6orf96 Homo sapiens (Human) TR33898_c0_g1_i1 Q8BVN4 MTER2_MOUSE 2.00E-09 GO:0043010; GO:0007507; GO:0005762; GO:0006626; GO:0019843; GO:0006364; GO:0042255; GO:0006390 camera-type eye development; heart development; mitochondrial large ribosomal subunit; protein targeting to mitochondrion; rRNA binding; rRNA processing; ribosome assembly; transcription from mitochondrial promoter IPR003690; mTERF domain-containing protein 2 (Mitochondrial transcription termination factor 4) (MTERF4) Mterfd2 Mus musculus (Mouse) TR33898_c0_g1_i2 Q8BVN4 MTER2_MOUSE 4.00E-16 GO:0043010; GO:0007507; GO:0005762; GO:0006626; GO:0019843; GO:0006364; GO:0042255; GO:0006390 camera-type eye development; heart development; mitochondrial large ribosomal subunit; protein targeting to mitochondrion; rRNA binding; rRNA processing; ribosome assembly; transcription from mitochondrial promoter IPR003690; mTERF domain-containing protein 2 (Mitochondrial transcription termination factor 4) (MTERF4) Mterfd2 Mus musculus (Mouse) TR339_c0_g2_i1 P24043 LAMA2_HUMAN 4.00E-10 GO:0007411; GO:0005604; GO:0007155; GO:0030198; GO:0005606; GO:0007517; GO:0032224; GO:0030155; GO:0030334; GO:0045995; GO:0042383; GO:0005198 "axon guidance; basement membrane; cell adhesion; extracellular matrix organization; laminin-1 complex; muscle organ development; positive regulation of synaptic transmission, cholinergic; regulation of cell adhesion; regulation of cell migration; regulation of embryonic development; sarcolemma; structural molecule activity" IPR008985; IPR013320; IPR002049; IPR008979; IPR018031; IPR000034; IPR001791; IPR009254; IPR010307; IPR008211; Laminin subunit alpha-2 (Laminin M chain) (Laminin-12 subunit alpha) (Laminin-2 subunit alpha) (Laminin-4 subunit alpha) (Merosin heavy chain) LAMA2 LAMM Homo sapiens (Human) TR33901_c1_g2_i2 P35544 UBIM_HUMAN 2.00E-15 IPR019956; IPR019954; IPR000626; Ubiquitin-like protein FUBI FAU Homo sapiens (Human) TR33901_c1_g2_i3 P35544 UBIM_HUMAN 1.00E-15 IPR019956; IPR019954; IPR000626; Ubiquitin-like protein FUBI FAU Homo sapiens (Human) TR33902_c10_g1_i1 Q6PD10 IP6K1_MOUSE 7.00E-32 GO:0005524; GO:0005737; GO:0052723; GO:0052724; GO:0000832; GO:0006020; GO:0032958; GO:0008440; GO:0005730; GO:0005634; GO:0046854 "ATP binding; cytoplasm; inositol hexakisphosphate 1-kinase activity; inositol hexakisphosphate 3-kinase activity; inositol hexakisphosphate 5-kinase activity; inositol metabolic process; inositol phosphate biosynthetic process; inositol-1,4,5-trisphosphate 3-kinase activity; nucleolus; nucleus; phosphatidylinositol phosphorylation" IPR005522; Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1) Ip6k1 Ihpk1 Mus musculus (Mouse) TR33902_c2_g1_i1 Q9ESM0 IP6K1_RAT 1.00E-41 GO:0005524; GO:0005737; GO:0052723; GO:0052724; GO:0000832; GO:0008440; GO:0005730; GO:0046854 "ATP binding; cytoplasm; inositol hexakisphosphate 1-kinase activity; inositol hexakisphosphate 3-kinase activity; inositol hexakisphosphate 5-kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; nucleolus; phosphatidylinositol phosphorylation" IPR005522; Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1) Ip6k1 Ihpk1 Rattus norvegicus (Rat) TR33902_c2_g2_i1 Q9R0U1 IP6K2_RAT 9.00E-34 GO:0005524; GO:0052723; GO:0052724; GO:0000832; GO:0008440; GO:0030308; GO:0005634; GO:0006817; GO:0046854; GO:0043065 "ATP binding; inositol hexakisphosphate 1-kinase activity; inositol hexakisphosphate 3-kinase activity; inositol hexakisphosphate 5-kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; negative regulation of cell growth; nucleus; phosphate ion transport; phosphatidylinositol phosphorylation; positive regulation of apoptotic process" IPR005522; Inositol hexakisphosphate kinase 2 (InsP6 kinase 2) (EC 2.7.4.21) (P(i)-uptake stimulator) (PiUS) Ip6k2 Ihpk2 Pius Rattus norvegicus (Rat) TR33902_c4_g1_i1 Q12494 KCS1_YEAST 7.00E-07 GO:0005524; GO:0005737; GO:0033200; GO:0052723; GO:0052724; GO:0000832; GO:0000828; GO:0032958; GO:0000827; GO:0008440 "ATP binding; cytoplasm; inositol heptakisphosphate 5-kinase activity; inositol hexakisphosphate 1-kinase activity; inositol hexakisphosphate 3-kinase activity; inositol hexakisphosphate 5-kinase activity; inositol hexakisphosphate kinase activity; inositol phosphate biosynthetic process; inositol-1,3,4,5,6-pentakisphosphate kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity" IPR005522; Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (InsP6 kinase KCS1) (PKC1 suppressor protein 1) KCS1 YDR017C PZF1050 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33904_c7_g2_i4 Q9Y251 HPSE_HUMAN 2.00E-86 GO:0004566; GO:0005975; GO:0007160; GO:0005576; GO:0006027; GO:0030200; GO:0030305; GO:0043202; GO:0005765; GO:0045121; GO:0005634; GO:0030194; GO:0051798; GO:0033690; GO:0051897; GO:0010575; GO:0046983; GO:0051797; GO:0045545; GO:0061042 beta-glucuronidase activity; carbohydrate metabolic process; cell-matrix adhesion; extracellular region; glycosaminoglycan catabolic process; heparan sulfate proteoglycan catabolic process; heparanase activity; lysosomal lumen; lysosomal membrane; membrane raft; nucleus; positive regulation of blood coagulation; positive regulation of hair follicle development; positive regulation of osteoblast proliferation; positive regulation of protein kinase B signaling cascade; positive regulation vascular endothelial growth factor production; protein dimerization activity; regulation of hair follicle development; syndecan binding; vascular wound healing IPR005199; IPR013781; IPR017853; Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit] HPSE HEP HPA HPA1 HPR1 HPSE1 HSE1 Homo sapiens (Human) TR33904_c7_g2_i7 Q9Y251 HPSE_HUMAN 4.00E-69 GO:0004566; GO:0005975; GO:0007160; GO:0005576; GO:0006027; GO:0030200; GO:0030305; GO:0043202; GO:0005765; GO:0045121; GO:0005634; GO:0030194; GO:0051798; GO:0033690; GO:0051897; GO:0010575; GO:0046983; GO:0051797; GO:0045545; GO:0061042 beta-glucuronidase activity; carbohydrate metabolic process; cell-matrix adhesion; extracellular region; glycosaminoglycan catabolic process; heparan sulfate proteoglycan catabolic process; heparanase activity; lysosomal lumen; lysosomal membrane; membrane raft; nucleus; positive regulation of blood coagulation; positive regulation of hair follicle development; positive regulation of osteoblast proliferation; positive regulation of protein kinase B signaling cascade; positive regulation vascular endothelial growth factor production; protein dimerization activity; regulation of hair follicle development; syndecan binding; vascular wound healing IPR005199; IPR013781; IPR017853; Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit] HPSE HEP HPA HPA1 HPR1 HPSE1 HSE1 Homo sapiens (Human) TR33905_c0_g1_i1 Q54KA7 SECG_DICDI 1.00E-13 GO:0005086; GO:0031589; GO:0006935; GO:0005829; GO:0005764; GO:0005543; GO:0032012 ARF guanyl-nucleotide exchange factor activity; cell-substrate adhesion; chemotaxis; cytosol; lysosome; phospholipid binding; regulation of ARF protein signal transduction IPR002110; IPR020683; IPR011993; IPR001849; IPR023394; IPR000904; "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) TR33905_c0_g1_i2 Q0P5B9 ANR39_BOVIN 7.00E-44 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 39 ANKRD39 Bos taurus (Bovine) TR33906_c0_g1_i4 Q803H0 CG025_DANRE 4.00E-57 IPR010733; UPF0415 protein C7orf25 homolog zgc:55781 Danio rerio (Zebrafish) (Brachydanio rerio) TR33907_c8_g1_i7 Q3ZBM7 TRPT1_BOVIN 2.00E-65 GO:0000215; GO:0006388 "tRNA 2'-phosphotransferase activity; tRNA splicing, via endonucleolytic cleavage and ligation" IPR002745; tRNA 2'-phosphotransferase 1 (EC 2.7.1.160) TRPT1 Bos taurus (Bovine) TR33910_c0_g1_i4 A1L2P2 C212A_XENLA 5.00E-18 GO:0016021 integral to membrane Small integral membrane protein 12-A smim12-a Xenopus laevis (African clawed frog) TR33911_c0_g1_i1 Q5R4R3 OGFD1_PONAB 6.00E-72 GO:0031418; GO:0005737; GO:0005506; GO:0005634; GO:0016706 "L-ascorbic acid binding; cytoplasm; iron ion binding; nucleus; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" IPR005123; IPR019601; IPR006620; 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 (EC 1.14.11.-) OGFOD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR33912_c1_g1_i4 Q5RFW0 SCAR5_DANRE 8.00E-08 GO:0006879; GO:0070287; GO:0005887; GO:0034755; GO:0070207; GO:0005044 cellular iron ion homeostasis; ferritin receptor activity; integral to plasma membrane; iron ion transmembrane transport; protein homotrimerization; scavenger receptor activity IPR008160; IPR001190; IPR017448; Scavenger receptor class A member 5 scara5 si:ch211-200p13.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR33912_c2_g1_i1 A0MSJ1 CRA1B_DANRE 1.00E-18 GO:0030282; GO:0005581; GO:0005201; GO:0046872; GO:0048570; GO:0001501 bone mineralization; collagen; extracellular matrix structural constituent; metal ion binding; notochord morphogenesis; skeletal system development IPR008160; IPR008985; IPR013320; IPR000885; IPR001791; Collagen alpha-1(XXVII) chain B col27a1b col27a1 Danio rerio (Zebrafish) (Brachydanio rerio) TR33914_c1_g1_i2 Q8MJJ1 SPG21_BOVIN 7.00E-139 GO:0042609; GO:0005829; GO:0005634; GO:0030140 CD4 receptor binding; cytosol; nucleus; trans-Golgi network transport vesicle IPR026151; Maspardin (Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog) SPG21 Bos taurus (Bovine) TR33915_c1_g1_i1 A2VDD2 TC1DB_XENLA 5.00E-63 IPR005334; Tctex1 domain-containing protein 1-B (Fragment) tctex1d1-b Xenopus laevis (African clawed frog) TR33916_c0_g2_i1 Q9NYQ6 CELR1_HUMAN 2.00E-26 GO:0004930; GO:0007266; GO:0009952; GO:0045176; GO:0005509; GO:0007417; GO:0048105; GO:0001736; GO:0042249; GO:0001942; GO:0007156; GO:0042472; GO:0005887; GO:0060490; GO:0007626; GO:0001843; GO:0001764; GO:0007218; GO:0060488; GO:0090179; GO:0060489; GO:0046983; GO:0090251; GO:0032956; GO:0042060 G-protein coupled receptor activity; Rho protein signal transduction; anterior/posterior pattern specification; apical protein localization; calcium ion binding; central nervous system development; establishment of body hair planar orientation; establishment of planar polarity; establishment of planar polarity of embryonic epithelium; hair follicle development; homophilic cell adhesion; inner ear morphogenesis; integral to plasma membrane; lateral sprouting involved in lung morphogenesis; locomotory behavior; neural tube closure; neuron migration; neuropeptide signaling pathway; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis; planar cell polarity pathway involved in neural tube closure; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis; protein dimerization activity; protein localization involved in establishment of planar polarity; regulation of actin cytoskeleton organization; wound healing IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR013032; IPR000152; IPR002049; IPR017981; IPR001879; IPR000832; IPR000203; IPR009030; IPR001791; Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2) CELSR1 CDHF9 FMI2 Homo sapiens (Human) TR33916_c5_g1_i1 Q9ULB4 CADH9_HUMAN 4.00E-09 GO:0034332; GO:0005509; GO:0034329; GO:0007156; GO:0016021; GO:0005886 adherens junction organization; calcium ion binding; cell junction assembly; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR000233; IPR027397; Cadherin-9 CDH9 Homo sapiens (Human) TR33917_c0_g1_i1 Q6ZMG9 CERS6_HUMAN 9.00E-78 GO:0046513; GO:0005789; GO:0016021; GO:0031965; GO:0043565; GO:0003700; GO:0044281; GO:0030148; GO:0050291 ceramide biosynthetic process; endoplasmic reticulum membrane; integral to membrane; nuclear membrane; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; small molecule metabolic process; sphingolipid biosynthetic process; sphingosine N-acyltransferase activity IPR001356; IPR009057; IPR016439; IPR006634; Ceramide synthase 6 (CerS6) (LAG1 longevity assurance homolog 6) CERS6 LASS6 Homo sapiens (Human) TR33917_c0_g1_i2 Q6ZMG9 CERS6_HUMAN 5.00E-26 GO:0046513; GO:0005789; GO:0016021; GO:0031965; GO:0043565; GO:0003700; GO:0044281; GO:0030148; GO:0050291 ceramide biosynthetic process; endoplasmic reticulum membrane; integral to membrane; nuclear membrane; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; small molecule metabolic process; sphingolipid biosynthetic process; sphingosine N-acyltransferase activity IPR001356; IPR009057; IPR016439; IPR006634; Ceramide synthase 6 (CerS6) (LAG1 longevity assurance homolog 6) CERS6 LASS6 Homo sapiens (Human) TR33918_c0_g2_i3 Q08258 GLTB_HORVU 1.00E-87 GO:0051538; GO:0097054; GO:0009570; GO:0016041; GO:0006541; GO:0046872 "3 iron, 4 sulfur cluster binding; L-glutamate biosynthetic process; chloroplast stroma; glutamate synthase (ferredoxin) activity; glutamine metabolic process; metal ion binding" IPR017932; IPR000583; Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (ferredoxin route): step 1/1. Energy metabolism; nitrogen metabolism. Ferredoxin-dependent glutamate synthase (EC 1.4.7.1) (FD-GOGAT) (Fragment) Hordeum vulgare (Barley) TR33918_c1_g2_i2 Q0JKD0 GLT1_ORYSJ 0 GO:0051538; GO:0010181; GO:0097054; GO:0019676; GO:0009507; GO:0048589; GO:0050660; GO:0006537; GO:0016040; GO:0005506; GO:0009536; GO:0060359 "3 iron, 4 sulfur cluster binding; FMN binding; L-glutamate biosynthetic process; ammonia assimilation cycle; chloroplast; developmental growth; flavin adenine dinucleotide binding; glutamate biosynthetic process; glutamate synthase (NADH) activity; iron ion binding; plastid; response to ammonium ion" IPR013785; IPR028261; IPR017932; IPR000583; IPR002489; IPR002932; IPR006982; IPR012220; IPR006005; IPR009051; IPR023753; Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1. Energy metabolism; nitrogen metabolism. "Glutamate synthase 1 [NADH], chloroplastic (EC 1.4.1.14) (NADH-dependent glutamate synthase 1) (NADH-GOGAT 1)" Os01g0681900 LOC_Os01g48960 Oryza sativa subsp. japonica (Rice) TR33918_c1_g4_i1 O34399 GLTB_BACSU 6.00E-143 GO:0097054; GO:0050660; GO:0004355; GO:0051536 L-glutamate biosynthetic process; flavin adenine dinucleotide binding; glutamate synthase (NADPH) activity; iron-sulfur cluster binding IPR028261; IPR006005; IPR009051; IPR016040; IPR023753; IPR001327; Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NADP(+) route): step 1/1. Energy metabolism; nitrogen metabolism. Glutamate synthase [NADPH] small chain (EC 1.4.1.13) (NADPH-GOGAT) gltB BSU18440 Bacillus subtilis (strain 168) TR33919_c0_g1_i2 Q66JT5 TPGS2_MOUSE 2.00E-74 GO:0005737; GO:0005874 cytoplasm; microtubule IPR018958; Tubulin polyglutamylase complex subunit 2 (PGs2) Tpgs2 Mus musculus (Mouse) TR33920_c1_g1_i2 Q9Y530 CF130_HUMAN 9.00E-61 GO:0019213; GO:0001883; GO:0042278 P09874; Q53GL7 deacetylase activity; purine nucleoside binding; purine nucleoside metabolic process IPR002589; O-acetyl-ADP-ribose deacetylase 1 (EC 3.5.1.-) OARD1 C6orf130 Homo sapiens (Human) TR33920_c1_g1_i4 Q1LZ74 CF130_BOVIN 2.00E-33 GO:0019213; GO:0001883; GO:0042278 deacetylase activity; purine nucleoside binding; purine nucleoside metabolic process IPR002589; O-acetyl-ADP-ribose deacetylase 1 (EC 3.5.1.-) OARD1 Bos taurus (Bovine) TR33921_c4_g1_i1 P49900 ARGI_LITCT 9.00E-118 GO:0004053; GO:0006525; GO:0046872; GO:0000050 arginase activity; arginine metabolic process; metal ion binding; urea cycle IPR014033; IPR006035; IPR023696; IPR020855; Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1. "Arginase, hepatic (EC 3.5.3.1)" Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) TR33921_c4_g1_i2 O42887 SPEB2_SCHPO 1.00E-09 GO:0008783; GO:0006520; GO:0005783; GO:0000324; GO:0030145; GO:0019627 agmatinase activity; cellular amino acid metabolic process; endoplasmic reticulum; fungal-type vacuole; manganese ion binding; urea metabolic process IPR006035; IPR023696; IPR020855; Putative agmatinase 2 (EC 3.5.3.11) (Agmatine ureohydrolase 2) (AUH 2) SPBC8E4.03 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR33921_c4_g1_i4 Q61176 ARGI1_MOUSE 2.00E-118 GO:0004053; GO:0006525; GO:0071549; GO:0071377; GO:0070301; GO:0071222; GO:0071560; GO:0032964; GO:0005737; GO:0005615; GO:0001889; GO:0030324; GO:0060056; GO:0030145; GO:0060135; GO:0043005; GO:0043025; GO:0001938; GO:0070207; GO:0010963; GO:0014075; GO:0043200; GO:0048678; GO:0046686; GO:0042493; GO:0009635; GO:0010042; GO:0051597; GO:0010269; GO:0033189; GO:0033197; GO:0010043; GO:0000050 arginase activity; arginine metabolic process; cellular response to dexamethasone stimulus; cellular response to glucagon stimulus; cellular response to hydrogen peroxide; cellular response to lipopolysaccharide; cellular response to transforming growth factor beta stimulus; collagen biosynthetic process; cytoplasm; extracellular space; liver development; lung development; mammary gland involution; manganese ion binding; maternal process involved in female pregnancy; neuron projection; neuronal cell body; positive regulation of endothelial cell proliferation; protein homotrimerization; regulation of L-arginine import; response to amine stimulus; response to amino acid stimulus; response to axon injury; response to cadmium ion; response to drug; response to herbicide; response to manganese ion; response to methylmercury; response to selenium ion; response to vitamin A; response to vitamin E; response to zinc ion; urea cycle IPR014033; IPR006035; IPR023696; IPR020855; Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1. Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase) Arg1 Mus musculus (Mouse) TR33922_c2_g1_i1 Q02974 KHK_RAT 3.00E-53 GO:0005524; GO:0016052; GO:0006000; GO:0004454; GO:0009750; GO:0009749; GO:0032868; GO:0009744; GO:0010043 ATP binding; carbohydrate catabolic process; fructose metabolic process; ketohexokinase activity; response to fructose stimulus; response to glucose stimulus; response to insulin stimulus; response to sucrose stimulus; response to zinc ion IPR011611; Carbohydrate metabolism; fructose metabolism. Ketohexokinase (EC 2.7.1.3) (Hepatic fructokinase) Khk Rattus norvegicus (Rat) TR33923_c2_g2_i1 Q5VYJ5 CJ112_HUMAN 4.00E-14 GO:0016021 integral to membrane IPR008985; IPR023415; IPR002172; IPR000998; MAM and LDL-receptor class A domain-containing protein C10orf112 C10orf112 Homo sapiens (Human) TR33923_c2_g2_i2 Q5VYJ5 CJ112_HUMAN 3.00E-14 GO:0016021 integral to membrane IPR008985; IPR023415; IPR002172; IPR000998; MAM and LDL-receptor class A domain-containing protein C10orf112 C10orf112 Homo sapiens (Human) TR33923_c3_g1_i1 P97793 ALK_MOUSE 3.00E-159 GO:0005524; GO:0000187; GO:0005887; GO:0048666; GO:0004714; GO:0007169 ATP binding; activation of MAPK activity; integral to plasma membrane; neuron development; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR026830; IPR008985; IPR011009; IPR002172; IPR000998; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR002011; ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) Alk Mus musculus (Mouse) TR33924_c0_g1_i2 A0JPH7 CE41B_XENLA 1.00E-71 GO:0005814; GO:0042384; GO:0036064; GO:0072372; GO:0018095; GO:0015031 centriole; cilium assembly; cilium basal body; primary cilium; protein polyglutamylation; protein transport IPR001763; Centrosomal protein of 41 kDa B (Cep41-B) cep41-b Xenopus laevis (African clawed frog) TR33925_c1_g1_i1 P12270 TPR_HUMAN 9.00E-27 GO:0005524; GO:0000189; GO:0006404; GO:0005975; GO:0051301; GO:0035457; GO:0003682; GO:0019221; GO:0005868; GO:0070840; GO:0019898; GO:0015758; GO:0031072; GO:0000776; GO:0003729; GO:0031990; GO:0051019; GO:0007067; GO:0007077; GO:0072686; GO:0007094; GO:0046832; GO:0000122; GO:0045947; GO:0042405; GO:0031965; GO:0034399; GO:0044615; GO:0006999; GO:0005487; GO:0005654; GO:0031453; GO:0090267; GO:0046827; GO:0042307; GO:0042803; GO:0010827; GO:0010965; GO:1901673; GO:0070849; GO:0004828; GO:0006434; GO:0044281; GO:0055085; GO:0015631; GO:0016032 ATP binding; MAPK import into nucleus; RNA import into nucleus; carbohydrate metabolic process; cell division; cellular response to interferon-alpha; chromatin binding; cytokine-mediated signaling pathway; cytoplasmic dynein complex; dynein complex binding; extrinsic to membrane; glucose transport; heat shock protein binding; kinetochore; mRNA binding; mRNA export from nucleus in response to heat stress; mitogen-activated protein kinase binding; mitosis; mitotic nuclear envelope disassembly; mitotic spindle; mitotic spindle assembly checkpoint; negative regulation of RNA export from nucleus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of translational initiation; nuclear inclusion body; nuclear membrane; nuclear periphery; nuclear pore nuclear basket; nuclear pore organization; nucleocytoplasmic transporter activity; nucleoplasm; positive regulation of heterochromatin assembly; positive regulation of mitotic cell cycle spindle assembly checkpoint; positive regulation of protein export from nucleus; positive regulation of protein import into nucleus; protein homodimerization activity; regulation of glucose transport; regulation of mitotic sister chromatid separation; regulation of spindle assembly involved in mitosis; response to epidermal growth factor stimulus; serine-tRNA ligase activity; seryl-tRNA aminoacylation; small molecule metabolic process; transmembrane transport; tubulin binding; viral process IPR015866; IPR012929; Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) TPR Homo sapiens (Human) TR33926_c5_g1_i1 P42519 STAR_DROME 2.00E-12 GO:0005794; GO:0000139; GO:0048149; GO:0046845; GO:0046667; GO:0035225; GO:0005789; GO:0038004; GO:0007173; GO:0061331; GO:0007476; GO:0016021; GO:0007498; GO:0016318; GO:0048477; GO:0097038; GO:0007422; GO:0042461; GO:0005886; GO:0000042; GO:0048865; GO:0007421; GO:0007601 "Golgi apparatus; Golgi membrane; behavioral response to ethanol; branched duct epithelial cell fate determination, open tracheal system; compound eye retinal cell programmed cell death; determination of genital disc primordium; endoplasmic reticulum membrane; epidermal growth factor receptor ligand maturation; epidermal growth factor receptor signaling pathway; epithelial cell proliferation involved in Malpighian tubule morphogenesis; imaginal disc-derived wing morphogenesis; integral to membrane; mesoderm development; ommatidial rotation; oogenesis; perinuclear endoplasmic reticulum; peripheral nervous system development; photoreceptor cell development; plasma membrane; protein targeting to Golgi; stem cell fate commitment; stomatogastric nervous system development; visual perception" IPR006342; Protein Star S CG4385 Drosophila melanogaster (Fruit fly) TR33927_c0_g1_i3 Q3T022 SAP18_BOVIN 6.00E-58 GO:0061574; GO:0005737; GO:0048025; GO:0016607; GO:0005886; GO:0043065; GO:0000381; GO:0006355; GO:0006351 "ASAP complex; cytoplasm; negative regulation of mRNA splicing, via spliceosome; nuclear speck; plasma membrane; positive regulation of apoptotic process; regulation of alternative mRNA splicing, via spliceosome; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR017250; IPR010516; Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p18) SAP18 Bos taurus (Bovine) TR33930_c0_g1_i2 Q04827 CCND2_RAT 1.00E-82 GO:0000082; GO:0051301; GO:0032869; GO:0005737; GO:0001889; GO:0016020; GO:0005634; GO:0001541; GO:0050679; GO:0000079; GO:0045664; GO:0051591; GO:0032355; GO:0045471; GO:0033574; GO:0007283 G1/S transition of mitotic cell cycle; cell division; cellular response to insulin stimulus; cytoplasm; liver development; membrane; nucleus; ovarian follicle development; positive regulation of epithelial cell proliferation; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of neuron differentiation; response to cAMP; response to estradiol stimulus; response to ethanol; response to testosterone stimulus; spermatogenesis IPR013763; IPR014400; IPR004367; IPR006671; G1/S-specific cyclin-D2 (Vin-1 proto-oncogene) Ccnd2 Vin-1 Rattus norvegicus (Rat) TR33930_c0_g1_i3 P49706 CCND2_CHICK 4.00E-86 GO:0007049; GO:0051301; GO:0000785; GO:0000307; GO:0005829; GO:0031965; GO:0005730; GO:0045737 cell cycle; cell division; chromatin; cyclin-dependent protein kinase holoenzyme complex; cytosol; nuclear membrane; nucleolus; positive regulation of cyclin-dependent protein kinase activity IPR013763; IPR014400; IPR004367; IPR006671; G1/S-specific cyclin-D2 CCND2 Gallus gallus (Chicken) TR33931_c1_g1_i2 Q9UII4 HERC5_HUMAN 4.00E-13 GO:0042296; GO:0032020; GO:0019221; GO:0005829; GO:0051607; GO:0045087; GO:0032480; GO:0005634; GO:0048471; GO:0042787; GO:0000079; GO:0050688; GO:0004842 ISG15 ligase activity; ISG15-protein conjugation; cytokine-mediated signaling pathway; cytosol; defense response to virus; innate immune response; negative regulation of type I interferon production; nucleus; perinuclear region of cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of defense response to virus; ubiquitin-protein ligase activity IPR000569; IPR009091; IPR000408; E3 ISG15--protein ligase HERC5 (EC 6.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5) HERC5 CEB1 CEBP1 Homo sapiens (Human) TR33931_c2_g1_i1 Q96Q42 ALS2_HUMAN 3.00E-37 GO:0017137; GO:0017112; GO:0030676; GO:0016601; GO:0005087; GO:0030424; GO:0007409; GO:0001662; GO:0008219; GO:0005813; GO:0005829; GO:0030425; GO:0043197; GO:0005769; GO:0016197; GO:0007032; GO:0030426; GO:0001701; GO:0030027; GO:0007626; GO:0016020; GO:0007528; GO:0048812; GO:0043025; GO:0005543; GO:0032855; GO:0035022; GO:0014069; GO:0043234; GO:0008104; GO:0043539; GO:0001881; GO:0032313; GO:0051036; GO:0006979; GO:0001726; GO:0035249; GO:0031982; GO:0016050 P20339 "Rab GTPase binding; Rab guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; Rac protein signal transduction; Ran guanyl-nucleotide exchange factor activity; axon; axonogenesis; behavioral fear response; cell death; centrosome; cytosol; dendrite; dendritic spine; early endosome; endosomal transport; endosome organization; growth cone; in utero embryonic development; lamellipodium; locomotory behavior; membrane; neuromuscular junction development; neuron projection morphogenesis; neuronal cell body; phospholipid binding; positive regulation of Rac GTPase activity; positive regulation of Rac protein signal transduction; postsynaptic density; protein complex; protein localization; protein serine/threonine kinase activator activity; receptor recycling; regulation of Rab GTPase activity; regulation of endosome size; response to oxidative stress; ruffle; synaptic transmission, glutamatergic; vesicle; vesicle organization" IPR000219; IPR003409; IPR011993; IPR001849; IPR009091; IPR000408; IPR003123; Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) ALS2 ALS2CR6 KIAA1563 Homo sapiens (Human) TR33931_c2_g1_i2 Q96Q42 ALS2_HUMAN 4.00E-43 GO:0017137; GO:0017112; GO:0030676; GO:0016601; GO:0005087; GO:0030424; GO:0007409; GO:0001662; GO:0008219; GO:0005813; GO:0005829; GO:0030425; GO:0043197; GO:0005769; GO:0016197; GO:0007032; GO:0030426; GO:0001701; GO:0030027; GO:0007626; GO:0016020; GO:0007528; GO:0048812; GO:0043025; GO:0005543; GO:0032855; GO:0035022; GO:0014069; GO:0043234; GO:0008104; GO:0043539; GO:0001881; GO:0032313; GO:0051036; GO:0006979; GO:0001726; GO:0035249; GO:0031982; GO:0016050 P20339 "Rab GTPase binding; Rab guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; Rac protein signal transduction; Ran guanyl-nucleotide exchange factor activity; axon; axonogenesis; behavioral fear response; cell death; centrosome; cytosol; dendrite; dendritic spine; early endosome; endosomal transport; endosome organization; growth cone; in utero embryonic development; lamellipodium; locomotory behavior; membrane; neuromuscular junction development; neuron projection morphogenesis; neuronal cell body; phospholipid binding; positive regulation of Rac GTPase activity; positive regulation of Rac protein signal transduction; postsynaptic density; protein complex; protein localization; protein serine/threonine kinase activator activity; receptor recycling; regulation of Rab GTPase activity; regulation of endosome size; response to oxidative stress; ruffle; synaptic transmission, glutamatergic; vesicle; vesicle organization" IPR000219; IPR003409; IPR011993; IPR001849; IPR009091; IPR000408; IPR003123; Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) ALS2 ALS2CR6 KIAA1563 Homo sapiens (Human) TR33933_c1_g2_i1 Q96P65 QRFPR_HUMAN 3.00E-06 GO:0004930; GO:0016021; GO:0004983; GO:0005886 G-protein coupled receptor activity; integral to membrane; neuropeptide Y receptor activity; plasma membrane IPR000276; IPR017452; IPR000611; Pyroglutamylated RFamide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155) QRFPR GPR103 Homo sapiens (Human) TR33933_c1_g2_i2 Q90334 ITR_CATCO 8.00E-07 GO:0016021; GO:0004990; GO:0005886; GO:0005000 integral to membrane; oxytocin receptor activity; plasma membrane; vasopressin receptor activity IPR000276; IPR017452; IPR002062; IPR001817; Isotocin receptor (ITR) Catostomus commersonii (White sucker) TR33934_c1_g1_i1 P07290 MLE_MIZYE 9.00E-53 GO:0005509; GO:0016459 calcium ion binding; myosin complex IPR011992; IPR002048; "Myosin, essential light chain, adductor muscle (Sulfhydryl light chain) (SHLC)" Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) TR33938_c0_g1_i3 Q9UJX5 APC4_HUMAN 3.00E-138 GO:0000086; GO:0005680; GO:0031145; GO:0051301; GO:0005829; GO:0007067; GO:0000090; GO:0007094; GO:0051436; GO:0005654; GO:0051437; GO:0070979; GO:0004842 Q8NI77; P51955 G2/M transition of mitotic cell cycle; anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; cytosol; mitosis; mitotic anaphase; mitotic spindle assembly checkpoint; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; protein K11-linked ubiquitination; ubiquitin-protein ligase activity IPR024789; IPR024790; IPR017169; IPR024977; IPR015943; IPR017986; Protein modification; protein ubiquitination. Anaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4) ANAPC4 APC4 Homo sapiens (Human) TR33938_c0_g1_i4 Q9UJX5 APC4_HUMAN 1.00E-80 GO:0000086; GO:0005680; GO:0031145; GO:0051301; GO:0005829; GO:0007067; GO:0000090; GO:0007094; GO:0051436; GO:0005654; GO:0051437; GO:0070979; GO:0004842 Q8NI77; P51955 G2/M transition of mitotic cell cycle; anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; cytosol; mitosis; mitotic anaphase; mitotic spindle assembly checkpoint; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; protein K11-linked ubiquitination; ubiquitin-protein ligase activity IPR024789; IPR024790; IPR017169; IPR024977; IPR015943; IPR017986; Protein modification; protein ubiquitination. Anaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4) ANAPC4 APC4 Homo sapiens (Human) TR33939_c0_g1_i1 Q01105 SET_HUMAN 1.00E-77 GO:0003677; GO:0006260; GO:0005829; GO:0005783; GO:0010467; GO:0042393; GO:0016071; GO:0035067; GO:0043524; GO:0045892; GO:0006913; GO:0005654; GO:0006334; GO:0006337; GO:0048471; GO:0043234; GO:0004864; GO:0008601 Q00987; P10644; P63000; Q15573; Q53T94; Q15572; P20226; P17480 "DNA binding; DNA replication; cytosol; endoplasmic reticulum; gene expression; histone binding; mRNA metabolic process; negative regulation of histone acetylation; negative regulation of neuron apoptotic process; negative regulation of transcription, DNA-dependent; nucleocytoplasmic transport; nucleoplasm; nucleosome assembly; nucleosome disassembly; perinuclear region of cytoplasm; protein complex; protein phosphatase inhibitor activity; protein phosphatase type 2A regulator activity" IPR002164; Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) SET Homo sapiens (Human) TR33940_c1_g1_i1 Q3C2P8 SPRE2_RAT 3.00E-30 GO:0000188; GO:0007275; GO:0010801; GO:0005886; GO:0043517; GO:0030291; GO:0090311; GO:0030658 "inactivation of MAPK activity; multicellular organismal development; negative regulation of peptidyl-threonine phosphorylation; plasma membrane; positive regulation of DNA damage response, signal transduction by p53 class mediator; protein serine/threonine kinase inhibitor activity; regulation of protein deacetylation; transport vesicle membrane" IPR023337; IPR011993; IPR007875; IPR000697; "Sprouty-related, EVH1 domain-containing protein 2 (Spred-2)" Spred2 Rattus norvegicus (Rat) TR33940_c4_g1_i3 Q0D289 CP052_DANRE 4.00E-51 Uncharacterized protein C16orf52 homolog zgc:153595 Danio rerio (Zebrafish) (Brachydanio rerio) TR33940_c8_g1_i1 Q7Z698 SPRE2_HUMAN 1.00E-12 GO:0000188; GO:0007275; GO:0010801; GO:0005886; GO:0043517; GO:0030291; GO:0090311; GO:0005173; GO:0030658 "inactivation of MAPK activity; multicellular organismal development; negative regulation of peptidyl-threonine phosphorylation; plasma membrane; positive regulation of DNA damage response, signal transduction by p53 class mediator; protein serine/threonine kinase inhibitor activity; regulation of protein deacetylation; stem cell factor receptor binding; transport vesicle membrane" IPR023337; IPR011993; IPR007875; IPR000697; "Sprouty-related, EVH1 domain-containing protein 2 (Spred-2)" SPRED2 Homo sapiens (Human) TR33941_c0_g1_i1 Q29RM1 TPC_BOVIN 3.00E-83 GO:0016021; GO:0005743; GO:0055085 integral to membrane; mitochondrial inner membrane; transmembrane transport IPR002067; IPR018108; IPR023395; Mitochondrial thiamine pyrophosphate carrier (Solute carrier family 25 member 19) SLC25A19 DNC Bos taurus (Bovine) TR33942_c3_g4_i1 Q9JHI0 MMP19_MOUSE 1.00E-40 GO:0031225; GO:0001525; GO:0005509; GO:0030154; GO:0030574; GO:0004222; GO:0005886; GO:0005578; GO:0006508; GO:0008270 anchored to membrane; angiogenesis; calcium ion binding; cell differentiation; collagen catabolic process; metalloendopeptidase activity; plasma membrane; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000585; IPR018487; IPR018486; IPR024079; IPR001818; IPR021190; IPR016293; IPR006026; IPR002477; Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI) Mmp19 Rasi Mus musculus (Mouse) TR33942_c3_g4_i2 Q9JHI0 MMP19_MOUSE 2.00E-39 GO:0031225; GO:0001525; GO:0005509; GO:0030154; GO:0030574; GO:0004222; GO:0005886; GO:0005578; GO:0006508; GO:0008270 anchored to membrane; angiogenesis; calcium ion binding; cell differentiation; collagen catabolic process; metalloendopeptidase activity; plasma membrane; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000585; IPR018487; IPR018486; IPR024079; IPR001818; IPR021190; IPR016293; IPR006026; IPR002477; Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI) Mmp19 Rasi Mus musculus (Mouse) TR33949_c7_g3_i1 Q86W74 ANR46_HUMAN 7.00E-22 GO:0016021 integral to membrane IPR002110; IPR020683; Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S) ANKRD46 Homo sapiens (Human) TR3395_c0_g1_i1 Q9DGD1 MGT4C_CHICK 1.00E-22 GO:0000139; GO:0008454; GO:0016021; GO:0046872; GO:0006486 "Golgi membrane; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; integral to membrane; metal ion binding; protein glycosylation" IPR006759; Protein modification; protein glycosylation. "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.-) (EC 2.4.1.145) (N-acetylglucosaminyltransferase VI) (GnT-VI) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)" MGAT4C Gallus gallus (Chicken) TR33950_c3_g1_i1 Q9I8W8 AL1A2_TAEGU 0 GO:0005737; GO:0001758; GO:0042572 cytoplasm; retinal dehydrogenase activity; retinol metabolic process IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Cofactor metabolism; retinol metabolism. Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II)) (zRalDH) ALDH1A2 RALDH2 Taeniopygia guttata (Zebra finch) (Poephila guttata) TR33950_c3_g1_i2 P30907 AL3A1_BOVIN 1.00E-16 GO:0004030; GO:0006081; GO:0005737 aldehyde dehydrogenase [NAD(P)+] activity; cellular aldehyde metabolic process; cytoplasm IPR016161; IPR016163; IPR016160; IPR015590; IPR012394; "Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (Aldehyde dehydrogenase 3) (Aldehyde dehydrogenase family 3 member A1) (Corneal 15.8 kDa protein) (Corneal protein 54) (bCP54) (Transparentin) (Fragment)" ALDH3A1 ALDH3 Bos taurus (Bovine) TR33950_c3_g1_i3 O94788 AL1A2_HUMAN 0 GO:0004028; GO:0042904; GO:0009952; GO:0001568; GO:0048738; GO:0071300; GO:0005737; GO:0005829; GO:0009855; GO:0031076; GO:0048566; GO:0035115; GO:0060324; GO:0003007; GO:0030902; GO:0001822; GO:0001889; GO:0030324; GO:0007494; GO:0016331; GO:0008285; GO:0014032; GO:0021915; GO:0030182; GO:0005634; GO:0031016; GO:0048471; GO:0021983; GO:0043065; GO:0008284; GO:0010628; GO:0009954; GO:0001936; GO:0034097; GO:0032355; GO:0033189; GO:0016918; GO:0001758; GO:0042574; GO:0042573; GO:0048384; GO:0042572; GO:0035799; GO:0006776 3-chloroallyl aldehyde dehydrogenase activity; 9-cis-retinoic acid biosynthetic process; anterior/posterior pattern specification; blood vessel development; cardiac muscle tissue development; cellular response to retinoic acid; cytoplasm; cytosol; determination of bilateral symmetry; embryonic camera-type eye development; embryonic digestive tract development; embryonic forelimb morphogenesis; face development; heart morphogenesis; hindbrain development; kidney development; liver development; lung development; midgut development; morphogenesis of embryonic epithelium; negative regulation of cell proliferation; neural crest cell development; neural tube development; neuron differentiation; nucleus; pancreas development; perinuclear region of cytoplasm; pituitary gland development; positive regulation of apoptotic process; positive regulation of cell proliferation; positive regulation of gene expression; proximal/distal pattern formation; regulation of endothelial cell proliferation; response to cytokine stimulus; response to estradiol stimulus; response to vitamin A; retinal binding; retinal dehydrogenase activity; retinal metabolic process; retinoic acid metabolic process; retinoic acid receptor signaling pathway; retinol metabolic process; ureter maturation; vitamin A metabolic process IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Cofactor metabolism; retinol metabolism. Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II)) ALDH1A2 RALDH2 Homo sapiens (Human) TR33954_c0_g1_i1 P00522 ABL_DROME 3.00E-19 GO:0005524; GO:0045179; GO:0030424; GO:0016199; GO:0005911; GO:0007417; GO:0007303; GO:0005829; GO:0007391; GO:0003382; GO:0019897; GO:0008045; GO:0005927; GO:0045886; GO:0001764; GO:0004715; GO:0003402; GO:0008064; GO:0008360; GO:0032880; GO:0031647; GO:0007370 Q8T4F7; P16621 "ATP binding; apical cortex; axon; axon midline choice point recognition; cell-cell junction; central nervous system development; cytoplasmic transport, nurse cell to oocyte; cytosol; dorsal closure; epithelial cell morphogenesis; extrinsic to plasma membrane; motor neuron axon guidance; muscle tendon junction; negative regulation of synaptic growth at neuromuscular junction; neuron migration; non-membrane spanning protein tyrosine kinase activity; planar cell polarity pathway involved in axis elongation; regulation of actin polymerization or depolymerization; regulation of cell shape; regulation of protein localization; regulation of protein stability; ventral furrow formation" IPR015015; IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase Abl (EC 2.7.10.2) (D-ash) (Protein abelson) Abl ABL-1 Dash CG4032 Drosophila melanogaster (Fruit fly) TR33954_c1_g1_i1 Q7Z3E1 PARPT_HUMAN 3.00E-19 GO:0003950; GO:0008209; GO:0008210; GO:0060325; GO:0008585; GO:0030097; GO:0001822; GO:0046872; GO:0044236; GO:0006807; GO:0060021; GO:0048008; GO:0009791; GO:0006471; GO:0048705; GO:0048745; GO:0001570 NAD+ ADP-ribosyltransferase activity; androgen metabolic process; estrogen metabolic process; face morphogenesis; female gonad development; hemopoiesis; kidney development; metal ion binding; multicellular organismal metabolic process; nitrogen compound metabolic process; palate development; platelet-derived growth factor receptor signaling pathway; post-embryonic development; protein ADP-ribosylation; skeletal system morphogenesis; smooth muscle tissue development; vasculogenesis IPR012317; IPR004170; IPR000571; TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) TIPARP PARP7 Homo sapiens (Human) TR33954_c1_g1_i3 Q9H0J9 PAR12_HUMAN 6.00E-19 GO:0003950; GO:0046872; GO:0005634 NAD+ ADP-ribosyltransferase activity; metal ion binding; nucleus IPR012317; IPR004170; IPR000571; Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) TR33956_c1_g1_i4 Q6R7K3 RIR2_OSHVF 4.00E-11 GO:0006260; GO:0009186; GO:0046872; GO:0004748 "DNA replication; deoxyribonucleoside diphosphate metabolic process; metal ion binding; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor" IPR009078; IPR003812; IPR012348; IPR000358; Genetic information processing; DNA replication. Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) ORF20 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) TR33957_c1_g1_i10 P69154 MT23A_MYTGA 2.00E-22 GO:0046872 metal ion binding IPR001008; IPR003019; Metallothionein 20-III isoform A (MT-20-IIIA) (MT-I) Mytilus galloprovincialis (Mediterranean mussel) TR33957_c1_g1_i13 P80252 MT22_MYTED 2.00E-17 GO:0046872 metal ion binding IPR024306; IPR001008; Metallothionein 20-II (MT-20-II) Mytilus edulis (Blue mussel) TR33958_c0_g1_i1 Q14432 PDE3A_HUMAN 8.00E-138 GO:0004115; GO:0007596; GO:0030552; GO:0006198; GO:0019933; GO:0004119; GO:0019934; GO:0071321; GO:0071560; GO:0005829; GO:0016101; GO:0016021; GO:0006629; GO:0046872; GO:0043066; GO:0043116; GO:0001556; GO:0060282; GO:0043117; GO:0040020; GO:0051591; GO:0042493 "3',5'-cyclic-AMP phosphodiesterase activity; blood coagulation; cAMP binding; cAMP catabolic process; cAMP-mediated signaling; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; cGMP-mediated signaling; cellular response to cGMP; cellular response to transforming growth factor beta stimulus; cytosol; diterpenoid metabolic process; integral to membrane; lipid metabolic process; metal ion binding; negative regulation of apoptotic process; negative regulation of vascular permeability; oocyte maturation; positive regulation of oocyte development; positive regulation of vascular permeability; regulation of meiosis; response to cAMP; response to drug" IPR003607; IPR002073; IPR023174; "cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A)" PDE3A Homo sapiens (Human) TR33958_c0_g1_i3 Q63421 PDE1C_RAT 9.00E-51 GO:0004115; GO:0030552; GO:0006198; GO:0046069; GO:0048101; GO:0004117; GO:0046872; GO:0046676; GO:0043025; GO:0051592; GO:0007608; GO:0007165 "3',5'-cyclic-AMP phosphodiesterase activity; cAMP binding; cAMP catabolic process; cGMP catabolic process; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; metal ion binding; negative regulation of insulin secretion; neuronal cell body; response to calcium ion; sensory perception of smell; signal transduction" IPR003607; IPR023088; IPR002073; IPR023174; IPR013706; "Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17)" Pde1c Rattus norvegicus (Rat) TR33958_c0_g1_i4 Q62865 PDE3A_RAT 8.00E-132 GO:0004115; GO:0030552; GO:0006198; GO:0019933; GO:0004119; GO:0019934; GO:0071321; GO:0071560; GO:0005829; GO:0016101; GO:0016021; GO:0046872; GO:0043066; GO:0043116; GO:0001556; GO:0060282; GO:0043117; GO:0040020; GO:0051591; GO:0042493 "3',5'-cyclic-AMP phosphodiesterase activity; cAMP binding; cAMP catabolic process; cAMP-mediated signaling; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; cGMP-mediated signaling; cellular response to cGMP; cellular response to transforming growth factor beta stimulus; cytosol; diterpenoid metabolic process; integral to membrane; metal ion binding; negative regulation of apoptotic process; negative regulation of vascular permeability; oocyte maturation; positive regulation of oocyte development; positive regulation of vascular permeability; regulation of meiosis; response to cAMP; response to drug" IPR003607; IPR002073; IPR023174; "cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A)" Pde3a Rattus norvegicus (Rat) TR33958_c0_g1_i5 Q14432 PDE3A_HUMAN 5.00E-137 GO:0004115; GO:0007596; GO:0030552; GO:0006198; GO:0019933; GO:0004119; GO:0019934; GO:0071321; GO:0071560; GO:0005829; GO:0016101; GO:0016021; GO:0006629; GO:0046872; GO:0043066; GO:0043116; GO:0001556; GO:0060282; GO:0043117; GO:0040020; GO:0051591; GO:0042493 "3',5'-cyclic-AMP phosphodiesterase activity; blood coagulation; cAMP binding; cAMP catabolic process; cAMP-mediated signaling; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; cGMP-mediated signaling; cellular response to cGMP; cellular response to transforming growth factor beta stimulus; cytosol; diterpenoid metabolic process; integral to membrane; lipid metabolic process; metal ion binding; negative regulation of apoptotic process; negative regulation of vascular permeability; oocyte maturation; positive regulation of oocyte development; positive regulation of vascular permeability; regulation of meiosis; response to cAMP; response to drug" IPR003607; IPR002073; IPR023174; "cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A)" PDE3A Homo sapiens (Human) TR33959_c1_g1_i1 Q95M71 BIRC8_GORGO 1.00E-27 GO:0006915; GO:0005737; GO:0008270 apoptotic process; cytoplasm; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis-like protein 2) (IAP-like protein 2) (ILP-2) BIRC8 ILP2 Gorilla gorilla gorilla (Lowland gorilla) TR33959_c1_g1_i2 A9ULZ2 BIR7B_XENLA 2.00E-26 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) TR33959_c1_g2_i2 Q5ZHS3 C1D_CHICK 1.00E-41 GO:0003677; GO:0003723; GO:0005737; GO:0005730; GO:0006364 DNA binding; RNA binding; cytoplasm; nucleolus; rRNA processing IPR011082; IPR007146; Nuclear nucleic acid-binding protein C1D C1D RCJMB04_33m12 Gallus gallus (Chicken) TR33960_c0_g1_i1 A4FVI0 ZSWM7_DANRE 2.00E-38 GO:0000724; GO:0005634; GO:0008270 double-strand break repair via homologous recombination; nucleus; zinc ion binding IPR007527; Zinc finger SWIM domain-containing protein 7 zswim7 si:ch211-31p3.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR33961_c1_g1_i1 O70437 SMAD4_RAT 0 GO:0003677; GO:0005737; GO:0046872; GO:0005634; GO:0043234; GO:0003700; GO:0005667; GO:0006351; GO:0007179 "DNA binding; cytoplasm; metal ion binding; nucleus; protein complex; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway" IPR013790; IPR003619; IPR013019; IPR017855; IPR001132; IPR008984; Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4) Smad4 Madh4 Rattus norvegicus (Rat) TR33961_c1_g1_i2 O70437 SMAD4_RAT 0 GO:0003677; GO:0005737; GO:0046872; GO:0005634; GO:0043234; GO:0003700; GO:0005667; GO:0006351; GO:0007179 "DNA binding; cytoplasm; metal ion binding; nucleus; protein complex; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway" IPR013790; IPR003619; IPR013019; IPR017855; IPR001132; IPR008984; Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4) Smad4 Madh4 Rattus norvegicus (Rat) TR33961_c1_g1_i3 P45896 SMA3_CAEEL 8.00E-23 GO:0030509; GO:0003677; GO:0005737; GO:0050832; GO:0045087; GO:0046872; GO:0002119; GO:0005634; GO:0045793; GO:0040018; GO:0046622; GO:0045944; GO:0003700; GO:0045138; GO:0005667; GO:0006351; GO:0007179; GO:0030618 "BMP signaling pathway; DNA binding; cytoplasm; defense response to fungus; innate immune response; metal ion binding; nematode larval development; nucleus; positive regulation of cell size; positive regulation of multicellular organism growth; positive regulation of organ growth; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; tail tip morphogenesis; transcription factor complex; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity" IPR013790; IPR003619; IPR013019; IPR017855; IPR001132; IPR008984; Dwarfin sma-3 (MAD protein homolog 2) sma-3 cem-2 R13F6.9 Caenorhabditis elegans TR33962_c0_g1_i2 O80792 RH33_ARATH 2.00E-09 GO:0005524; GO:0008026; GO:0003723 ATP binding; ATP-dependent helicase activity; RNA binding IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; Putative DEAD-box ATP-dependent RNA helicase 33 (EC 3.6.4.13) RH33 At2g07750 T12J2.7 Arabidopsis thaliana (Mouse-ear cress) TR33962_c0_g2_i1 Q9NY93 DDX56_HUMAN 4.00E-91 GO:0005524; GO:0004004; GO:0003723; GO:0005730; GO:0006364 ATP binding; ATP-dependent RNA helicase activity; RNA binding; nucleolus; rRNA processing IPR011545; IPR014001; IPR001650; IPR027417; Probable ATP-dependent RNA helicase DDX56 (EC 3.6.4.13) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD box protein 21) (DEAD box protein 56) DDX56 DDX21 NOH61 Homo sapiens (Human) TR33962_c0_g3_i1 Q5AZA6 DBP9_EMENI 5.00E-33 GO:0005524; GO:0008026; GO:0003723; GO:0005730; GO:0006364 ATP binding; ATP-dependent helicase activity; RNA binding; nucleolus; rRNA processing IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; ATP-dependent RNA helicase dbp9 (EC 3.6.4.13) dbp9 AN6374 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR33963_c0_g1_i1 A1JIG4 FADB_YERE8 4.00E-20 GO:0003857; GO:0008692; GO:0050662; GO:0004165; GO:0004300; GO:0006635 3-hydroxyacyl-CoA dehydrogenase activity; 3-hydroxybutyryl-CoA epimerase activity; coenzyme binding; dodecenoyl-CoA delta-isomerase activity; enoyl-CoA hydratase activity; fatty acid beta-oxidation IPR006180; IPR006176; IPR006108; IPR008927; IPR001753; IPR013328; IPR018376; IPR012799; IPR016040; Lipid metabolism; fatty acid beta-oxidation. Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase (EC 4.2.1.17) (EC 5.1.2.3) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)] fadB YE0268 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) TR33963_c0_g1_i2 P23965 ECI1_RAT 3.00E-89 GO:0004165; GO:0006635; GO:0042802; GO:0005759; GO:0005739 dodecenoyl-CoA delta-isomerase activity; fatty acid beta-oxidation; identical protein binding; mitochondrial matrix; mitochondrion IPR001753; IPR018376; Lipid metabolism; fatty acid beta-oxidation. "Enoyl-CoA delta isomerase 1, mitochondrial (EC 5.3.3.8) (3,2-trans-enoyl-CoA isomerase) (Delta(3),Delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase)" Eci1 Dci Rattus norvegicus (Rat) TR33964_c0_g1_i1 Q04545 TDA9_YEAST 3.00E-10 GO:0046872; GO:0005634; GO:0006355; GO:0043565; GO:0006351 "metal ion binding; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Probable transcription factor TDA9 (Topoisomerase I damage affected protein 9) TDA9 YML081W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33964_c1_g3_i1 P18744 ZO20_XENLA 2.00E-19 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Oocyte zinc finger protein XlCOF20 (Fragment) Xenopus laevis (African clawed frog) TR33964_c4_g4_i1 Q9C0F3 ZN436_HUMAN 4.00E-26 GO:0003677; GO:0005737; GO:0046872; GO:0005634; GO:0006355; GO:0006351 O43463 "DNA binding; cytoplasm; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 436 ZNF436 KIAA1710 Homo sapiens (Human) TR33966_c0_g1_i1 Q6DEW6 REXO4_XENTR 1.00E-75 GO:0004527; GO:0003676; GO:0090305; GO:0005634 exonuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis; nucleus IPR006055; IPR013520; IPR012337; RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein) rexo4 xpmc2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33966_c0_g1_i3 Q6DEW6 REXO4_XENTR 3.00E-74 GO:0004527; GO:0003676; GO:0090305; GO:0005634 exonuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis; nucleus IPR006055; IPR013520; IPR012337; RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein) rexo4 xpmc2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33968_c0_g1_i1 P35754 GLRX1_HUMAN 4.00E-17 GO:0045454; GO:0005829; GO:0009055; GO:0015038; GO:0005739; GO:0015949; GO:0005634; GO:0015035 cell redox homeostasis; cytosol; electron carrier activity; glutathione disulfide oxidoreductase activity; mitochondrion; nucleobase-containing small molecule interconversion; nucleus; protein disulfide oxidoreductase activity IPR011767; IPR002109; IPR011899; IPR014025; IPR012336; Glutaredoxin-1 (Thioltransferase-1) (TTase-1) GLRX GRX Homo sapiens (Human) TR33968_c0_g1_i2 Q19297 YZ73_CAEEL 1.00E-15 GO:0051537; GO:0045454; GO:0009055; GO:0046872; GO:0015035 "2 iron, 2 sulfur cluster binding; cell redox homeostasis; electron carrier activity; metal ion binding; protein disulfide oxidoreductase activity" IPR002109; IPR011899; IPR014025; IPR012336; Uncharacterized monothiol glutaredoxin F10D7.3 F10D7.3 Caenorhabditis elegans TR33969_c1_g1_i1 Q6GM59 MOT12_XENLA 9.00E-35 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 Xenopus laevis (African clawed frog) TR33969_c1_g1_i3 Q6ZSM3 MOT12_HUMAN 2.00E-44 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) SLC16A12 MCT12 Homo sapiens (Human) TR33969_c1_g1_i4 Q6GM59 MOT12_XENLA 4.00E-45 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 Xenopus laevis (African clawed frog) TR33971_c2_g1_i1 Q9TUD4 FUT1_GORGO 3.00E-30 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" FUT1 Gorilla gorilla gorilla (Lowland gorilla) TR33971_c3_g1_i1 P97353 SEC1_MOUSE 4.00E-39 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 3 (EC 2.4.1.69) (Alpha(1,2)FT 3) (Fucosyltransferase 10) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 3) (Secretory blood group protein 1)" Sec1 Fut10 Mus musculus (Mouse) TR33971_c5_g1_i2 Q7ZUC2 CAB45_DANRE 7.00E-50 GO:0005796; GO:0005509 Golgi lumen; calcium ion binding IPR027240; IPR011992; IPR018247; IPR002048; 45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4) sdf4 cab45 zgc:76916 Danio rerio (Zebrafish) (Brachydanio rerio) TR33973_c0_g1_i2 Q8N8G2 VGLL2_HUMAN 1.00E-13 GO:0005737; GO:0005634; GO:0045944; GO:0007519; GO:0003713; GO:0006351 "cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter; skeletal muscle tissue development; transcription coactivator activity; transcription, DNA-dependent" IPR006627; IPR011520; Transcription cofactor vestigial-like protein 2 (Vgl-2) (Protein VITO1) VGLL2 VITO1 Homo sapiens (Human) TR33973_c0_g1_i3 Q8BGW8 VGLL2_MOUSE 5.00E-15 GO:0005737; GO:0005634; GO:0045944; GO:0007519; GO:0003713; GO:0006351 "cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter; skeletal muscle tissue development; transcription coactivator activity; transcription, DNA-dependent" IPR011520; Transcription cofactor vestigial-like protein 2 (Vgl-2) (Protein VITO1) Vgll2 Vgl2 Vito1 Mus musculus (Mouse) TR33974_c5_g1_i1 Q2KN93 CYTSA_DANRE 1.00E-55 GO:0007049; GO:0051301; GO:0005737; GO:0005921; GO:0005819 cell cycle; cell division; cytoplasm; gap junction; spindle IPR001715; Cytospin-A (SPECC1-like protein) (Sperm antigen with calponin homology and coiled-coil domains 1-like) specc1la cytsa cytsaa specc1l im:7159316 si:dkey-118g10.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR33974_c5_g1_i2 Q9N4M4 ANC1_CAEEL 7.00E-09 GO:0003779; GO:0005737; GO:0005856; GO:0007010; GO:0016021; GO:0005640; GO:0035046 actin binding; cytoplasm; cytoskeleton; cytoskeleton organization; integral to membrane; nuclear outer membrane; pronuclear migration IPR001589; IPR001715; IPR012315; Nuclear anchorage protein 1 (Anchorage 1 protein) (Nesprin homolog) anc-1 T03A1.3/T03A1.4 ZK973.6 Caenorhabditis elegans TR33974_c7_g1_i1 P07291 MLE_AEQIR 6.00E-73 GO:0005509; GO:0016459 calcium ion binding; myosin complex IPR011992; IPR002048; "Myosin essential light chain, striated adductor muscle (E-LC) (Sulfhydryl light chain) (SHLC)" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR33976_c0_g2_i1 Q3B7U2 TAF1A_RAT 2.00E-30 GO:0003677; GO:0000120; GO:0006355; GO:0006360 "DNA binding; RNA polymerase I transcription factor complex; regulation of transcription, DNA-dependent; transcription from RNA polymerase I promoter" IPR016629; TATA box-binding protein-associated factor RNA polymerase I subunit A (TATA box-binding protein-associated factor 1A) (TBP-associated factor 1A) (Transcription initiation factor SL1/TIF-IB subunit A) Taf1a Rattus norvegicus (Rat) TR33977_c1_g1_i1 P89105 CTR9_YEAST 8.00E-06 GO:0016593; GO:0001076; GO:0031124; GO:2001255; GO:2001165; GO:2001209; GO:0031938; GO:2001173; GO:0051569; GO:0034401; GO:0060260; GO:0000083; GO:0090262; GO:0031126; GO:0001015; GO:0006362; GO:0006368; GO:0035327; GO:0045142 P38439; P38351; P53064; Q00772 Cdc73/Paf1 complex; RNA polymerase II transcription factor binding transcription factor activity; mRNA 3'-end processing; positive regulation of histone H3-K36 trimethylation; positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues; positive regulation of transcription elongation from RNA polymerase I promoter; regulation of chromatin silencing at telomere; regulation of histone H2B conserved C-terminal lysine ubiquitination; regulation of histone H3-K4 methylation; regulation of transcription by chromatin organization; regulation of transcription initiation from RNA polymerase II promoter; regulation of transcription involved in G1/S transition of mitotic cell cycle; regulation of transcription-coupled nucleotide-excision repair; snoRNA 3'-end processing; snoRNA transcription from an RNA polymerase II promoter; transcription elongation from RNA polymerase I promoter; transcription elongation from RNA polymerase II promoter; transcriptionally active chromatin; triplex DNA binding IPR013026; IPR011990; IPR001440; IPR013105; IPR019734; RNA polymerase-associated protein CTR9 (Centromere-binding factor 1-dependent protein 1) (Cln three-requiring protein 9) CTR9 CDP1 YOL145C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33978_c2_g1_i1 Q8N0N9 ODH_HALDH 4.00E-138 GO:0051287; GO:0005737; GO:0046168; GO:0016616 "NAD binding; cytoplasm; glycerol-3-phosphate catabolic process; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" IPR008927; IPR013328; IPR011128; IPR016040; IPR003421; Opine dehydrogenase (EC 1.5.1.-) tadh Haliotis discus hannai (Japanese abalone) TR33978_c2_g2_i1 Q8N0N9 ODH_HALDH 6.00E-120 GO:0051287; GO:0005737; GO:0046168; GO:0016616 "NAD binding; cytoplasm; glycerol-3-phosphate catabolic process; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" IPR008927; IPR013328; IPR011128; IPR016040; IPR003421; Opine dehydrogenase (EC 1.5.1.-) tadh Haliotis discus hannai (Japanese abalone) TR33980_c0_g1_i1 Q4R2Y2 HYLS1_MACFA 3.00E-06 GO:0005737 cytoplasm IPR026227; IPR027918; Hydrolethalus syndrome protein 1 homolog HYLS1 QtsA-21349 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR33981_c0_g1_i1 Q03484 CEBPD_RAT 2.00E-14 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; IPR016468; CCAAT/enhancer-binding protein delta (C/EBP delta) (Transcription factor CELF) Cebpd Celf Rattus norvegicus (Rat) TR33982_c0_g1_i1 Q28DZ1 IKKA_XENTR 6.00E-72 GO:0005524; GO:0007252; GO:0008384; GO:0071356; GO:0005737; GO:0005634; GO:0045944; GO:0046982; GO:0042803 ATP binding; I-kappaB phosphorylation; IkappaB kinase activity; cellular response to tumor necrosis factor; cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; protein homodimerization activity IPR011009; IPR000719; IPR008271; Inhibitor of nuclear factor kappa-B kinase subunit alpha (I kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) chuk ikka TEgg047h13.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR33982_c0_g2_i1 O14920 IKKB_HUMAN 2.00E-100 GO:0005524; GO:0001782; GO:0035631; GO:0038095; GO:0008384; GO:0008385; GO:0002755; GO:0050852; GO:0035666; GO:0071356; GO:0006954; GO:0045087; GO:0009898; GO:0045121; GO:0043066; GO:0048011; GO:0070423; GO:0005634; GO:0043123; GO:0051092; GO:2001259; GO:0010765; GO:0045944; GO:0032481; GO:0046982; GO:0042803; GO:0009615; GO:0042501; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124 O15111; Q9Y6K9; Q14145; Q99558; Q9Y6Q9; P25963; P67775; P23396; Q9UGK3; P03409; Q92574; P24772; Q5D1E7 ATP binding; B cell homeostasis; CD40 receptor complex; Fc-epsilon receptor signaling pathway; IkappaB kinase activity; IkappaB kinase complex; MyD88-dependent toll-like receptor signaling pathway; T cell receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; cellular response to tumor necrosis factor; inflammatory response; innate immune response; internal side of plasma membrane; membrane raft; negative regulation of apoptotic process; neurotrophin TRK receptor signaling pathway; nucleotide-binding oligomerization domain containing signaling pathway; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of cation channel activity; positive regulation of sodium ion transport; positive regulation of transcription from RNA polymerase II promoter; positive regulation of type I interferon production; protein heterodimerization activity; protein homodimerization activity; response to virus; serine phosphorylation of STAT protein; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor TLR1:TLR2 signaling pathway; toll-like receptor TLR6:TLR2 signaling pathway IPR022007; IPR011009; IPR000719; IPR008271; IPR000626; Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) IKBKB IKKB Homo sapiens (Human) TR33983_c1_g1_i10 Q4UKI1 Y1099_RICFE 5.00E-08 IPR002110; IPR020683; Putative ankyrin repeat protein RF_1099 RF_1099 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR33983_c1_g1_i2 Q6GQX6 ANKS6_MOUSE 2.00E-11 IPR002110; IPR020683; IPR001660; IPR013761; IPR021129; Ankyrin repeat and SAM domain-containing protein 6 (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6) Anks6 Gm635 Samd6 Mus musculus (Mouse) TR33983_c1_g1_i3 Q9DCN1 NUD12_MOUSE 6.00E-06 GO:0019677; GO:0000210; GO:0035529; GO:0006742; GO:0046872; GO:0005634; GO:0005777 NAD catabolic process; NAD+ diphosphatase activity; NADH pyrophosphatase activity; NADP catabolic process; metal ion binding; nucleus; peroxisome IPR002110; IPR020683; IPR015375; IPR020084; IPR000086; IPR015797; IPR015376; Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12) Nudt12 Mus musculus (Mouse) TR33983_c1_g1_i4 Q4UMH6 Y381_RICFE 5.00E-09 GO:0015969 guanosine tetraphosphate metabolic process IPR002110; IPR020683; IPR007685; Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR33983_c1_g1_i5 Q9ULH0 KDIS_HUMAN 7.00E-15 GO:0030165; GO:0000186; GO:0016482; GO:0005829; GO:0048813; GO:0001701; GO:0016021; GO:0005770; GO:0038180; GO:0048011; GO:0010976; GO:0043234 PDZ domain binding; activation of MAPKK activity; cytoplasmic transport; cytosol; dendrite morphogenesis; in utero embryonic development; integral to membrane; late endosome; nerve growth factor signaling pathway; neurotrophin TRK receptor signaling pathway; positive regulation of neuron projection development; protein complex IPR002110; IPR020683; IPR011646; IPR013761; Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) KIDINS220 ARMS KIAA1250 Homo sapiens (Human) TR33983_c1_g1_i6 Q8NB46 ANR52_HUMAN 4.00E-12 Q9UPN7 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) (Ankyrin repeat domain-containing protein 52) ANKRD52 Homo sapiens (Human) TR33983_c1_g1_i8 Q108U1 ASZ1_LOXAF 8.00E-12 GO:0043046; GO:0030154; GO:0031047; GO:0007140; GO:0007275; GO:0071546; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; cell differentiation; gene silencing by RNA; male meiosis; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002110; IPR020683; IPR011510; "Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)" ASZ1 GASZ Loxodonta africana (African elephant) TR33983_c1_g2_i1 Q08DV6 ASB3_BOVIN 3.00E-10 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 3 (ASB-3) ASB3 Bos taurus (Bovine) TR33983_c1_g4_i1 Q18297 TRPA1_CAEEL 7.00E-07 GO:0016021; GO:0005216; GO:0043025; GO:0031513; GO:0050896 integral to membrane; ion channel activity; neuronal cell body; nonmotile primary cilium; response to stimulus IPR002110; IPR020683; IPR005821; Transient receptor potential cation channel subfamily A member 1 homolog trpa-1 C29E6.2 Caenorhabditis elegans TR33983_c1_g5_i2 Q6PFX9 TNKS1_MOUSE 3.00E-12 GO:0005794; GO:0000139; GO:0003950; GO:0016055; GO:0051301; GO:0000775; GO:0051028; GO:0007067; GO:0043392; GO:0000784; GO:0005643; GO:0018105; GO:0018107; GO:0090263; GO:0032212; GO:0045944; GO:0070213; GO:0070198; GO:0070212; GO:0000209; GO:0015031; GO:0000922; GO:0008270 "Golgi apparatus; Golgi membrane; NAD+ ADP-ribosyltransferase activity; Wnt receptor signaling pathway; cell division; chromosome, centromeric region; mRNA transport; mitosis; negative regulation of DNA binding; nuclear chromosome, telomeric region; nuclear pore; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of telomere maintenance via telomerase; positive regulation of transcription from RNA polymerase II promoter; protein auto-ADP-ribosylation; protein localization to chromosome, telomeric region; protein poly-ADP-ribosylation; protein polyubiquitination; protein transport; spindle pole; zinc ion binding" IPR002110; IPR020683; IPR012317; IPR001660; IPR013761; IPR011510; Tankyrase-1 (TANK1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (TRF1-interacting ankyrin-related ADP-ribose polymerase 1) (Tankyrase I) Tnks Tnks1 Mus musculus (Mouse) TR33983_c1_g5_i3 Q2QLC6 ASZ1_CARPS 6.00E-10 GO:0043046; GO:0030154; GO:0031047; GO:0007140; GO:0007275; GO:0071546; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; cell differentiation; gene silencing by RNA; male meiosis; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002110; IPR020683; IPR013761; IPR011510; "Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)" ASZ1 GASZ Carollia perspicillata (Seba's short-tailed bat) TR33983_c1_g5_i4 Q09YI3 ASZ1_SHEEP 4.00E-13 GO:0043046; GO:0030154; GO:0031047; GO:0007140; GO:0007275; GO:0071546; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; cell differentiation; gene silencing by RNA; male meiosis; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002110; IPR020683; IPR001660; IPR013761; IPR011510; "Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)" ASZ1 GASZ Ovis aries (Sheep) TR33983_c1_g7_i1 Q3ZBX7 ANKR1_BOVIN 2.00E-09 GO:0003677; GO:0031674; GO:0001105; GO:0055008; GO:0035690; GO:0071347; GO:0071222; GO:0071260; GO:0071560; GO:0071356; GO:0005829; GO:2000279; GO:0005634; GO:0043517; GO:0043065; GO:0050714; GO:0035994; GO:0035914; GO:0003714; GO:0005667 "DNA binding; I band; RNA polymerase II transcription coactivator activity; cardiac muscle tissue morphogenesis; cellular response to drug; cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; cytosol; negative regulation of DNA biosynthetic process; nucleus; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of apoptotic process; positive regulation of protein secretion; response to muscle stretch; skeletal muscle cell differentiation; transcription corepressor activity; transcription factor complex" IPR002110; IPR020683; Ankyrin repeat domain-containing protein 1 ANKRD1 Bos taurus (Bovine) TR33983_c1_g7_i2 Q07E30 ASZ1_NEONE 1.00E-11 GO:0043046; GO:0030154; GO:0031047; GO:0007140; GO:0007275; GO:0071546; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; cell differentiation; gene silencing by RNA; male meiosis; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002110; IPR020683; IPR013761; IPR011510; "Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)" ASZ1 GASZ Neofelis nebulosa (Clouded leopard) TR33986_c1_g2_i1 Q8IVS2 FABD_HUMAN 3.00E-62 GO:0004314; GO:0006633; GO:0005739 [acyl-carrier-protein] S-malonyltransferase activity; fatty acid biosynthetic process; mitochondrion IPR001227; IPR014043; IPR016035; IPR016036; Lipid metabolism; fatty acid biosynthesis. "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCT) (EC 2.3.1.39) (Mitochondrial malonyl CoA:ACP acyltransferase) (Mitochondrial malonyltransferase) ([Acyl-carrier-protein] malonyltransferase)" MCAT MT Homo sapiens (Human) TR33986_c1_g2_i2 Q8T3L6 FABD_DROME 4.00E-56 GO:0004314; GO:0006633; GO:0005739 [acyl-carrier-protein] S-malonyltransferase activity; fatty acid biosynthetic process; mitochondrion IPR001227; IPR014043; IPR016035; IPR016036; Lipid metabolism; fatty acid biosynthesis. "Probable malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCT) (EC 2.3.1.39) (Bad egg) ([Acyl-carrier-protein] malonyltransferase)" beg CG7842 Drosophila melanogaster (Fruit fly) TR33986_c1_g3_i1 Q8IVS2 FABD_HUMAN 3.00E-16 GO:0004314; GO:0006633; GO:0005739 [acyl-carrier-protein] S-malonyltransferase activity; fatty acid biosynthetic process; mitochondrion IPR001227; IPR014043; IPR016035; IPR016036; Lipid metabolism; fatty acid biosynthesis. "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCT) (EC 2.3.1.39) (Mitochondrial malonyl CoA:ACP acyltransferase) (Mitochondrial malonyltransferase) ([Acyl-carrier-protein] malonyltransferase)" MCAT MT Homo sapiens (Human) TR33987_c2_g1_i1 P45444 DYHC_EMENI 7.00E-33 GO:0005524; GO:0016887; GO:0030428; GO:0005868; GO:0031122; GO:0001411; GO:0070789; GO:0005874; GO:0008017; GO:0008569; GO:0007097; GO:0047496 ATP binding; ATPase activity; cell septum; cytoplasmic dynein complex; cytoplasmic microtubule organization; hyphal tip; metula development; microtubule; microtubule binding; minus-end-directed microtubule motor activity; nuclear migration; vesicle transport along microtubule IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain, cytoplasmic (Dynein heavy chain, cytosolic) (DYHC)" nudA AN0118 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR33987_c4_g1_i2 Q8IVF4 DYH10_HUMAN 1.00E-78 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 10, axonemal (Axonemal beta dynein heavy chain 10) (Ciliary dynein heavy chain 10)" DNAH10 KIAA2017 Homo sapiens (Human) TR33987_c5_g1_i2 Q8IID4 DYHC2_PLAF7 2.00E-25 GO:0005524; GO:0006200; GO:0016887; GO:0005737; GO:0030286; GO:0005874; GO:0005875; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cytoplasm; dynein complex; microtubule; microtubule associated complex; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR017868; IPR013783; IPR014756; IPR015915; IPR027417; Dynein heavy chain-like protein PF11_0240 PF11_0240 Plasmodium falciparum (isolate 3D7) TR33987_c5_g1_i3 Q9UFH2 DYH17_HUMAN 5.00E-89 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 17, axonemal (Axonemal beta dynein heavy chain 17) (Axonemal dynein heavy chain-like protein 1) (Ciliary dynein heavy chain 17) (Ciliary dynein heavy chain-like protein 1) (Dynein light chain 2, axonemal)" DNAH17 DNAHL1 DNEL2 Homo sapiens (Human) TR33987_c5_g1_i5 Q63164 DYH1_RAT 0 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR026975; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 1, axonemal (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1)" Dnah1 Dlp1 Rattus norvegicus (Rat) TR33987_c5_g1_i6 Q63164 DYH1_RAT 2.00E-108 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR026975; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 1, axonemal (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1)" Dnah1 Dlp1 Rattus norvegicus (Rat) TR33987_c8_g1_i1 P38650 DYHC1_RAT 1.00E-06 GO:0005524; GO:0006200; GO:0016887; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement; transport IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) (MAP 1C)" Dync1h1 Dhc1 Dnch1 Dnchc1 Dnec1 Dyhc Map1c Rattus norvegicus (Rat) TR33988_c0_g1_i1 F1LMZ8 PSD11_RAT 0 GO:0005829; GO:0005634; GO:0022624; GO:0043248; GO:0048863; GO:0006511 cytosol; nucleus; proteasome accessory complex; proteasome assembly; stem cell differentiation; ubiquitin-dependent protein catabolic process IPR013143; IPR000717; IPR011990; IPR011991; 26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) Psmd11 Rattus norvegicus (Rat) TR33989_c0_g2_i1 P0CZ23 ACOX3_ARATH 2.00E-86 GO:0003995; GO:0003997; GO:0006635; GO:0033540; GO:0050660; GO:0051791; GO:0005777 acyl-CoA dehydrogenase activity; acyl-CoA oxidase activity; fatty acid beta-oxidation; fatty acid beta-oxidation using acyl-CoA oxidase; flavin adenine dinucleotide binding; medium-chain fatty acid metabolic process; peroxisome IPR006091; IPR012258; IPR002655; IPR009075; IPR009100; Lipid metabolism; peroxisomal fatty acid beta-oxidation. "Acyl-coenzyme A oxidase 3, peroxisomal (AOX 3) (Acyl-CoA oxidase 3) (EC 1.3.3.6) (Medium-chain acyl-CoA oxidase) (AtCX3)" ACX3 At1g06290 At1g06300 F9P14.15 F9P14_11 T2D23.1 Arabidopsis thaliana (Mouse-ear cress) TR3399_c0_g1_i1 Q9HBL7 PLRKT_HUMAN 3.00E-17 GO:0006935; GO:0006954; GO:0005887; GO:0005739; GO:0010756 chemotaxis; inflammatory response; integral to plasma membrane; mitochondrion; positive regulation of plasminogen activation IPR019319; Plasminogen receptor (KT) (Plg-R(KT)) PLGRKT C9orf46 AD025 MDS030 Homo sapiens (Human) TR33990_c0_g1_i2 Q9K907 PRPE_BACHD 1.00E-14 GO:0005525; GO:0004081; GO:0016151 GTP binding; bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity; nickel cation binding IPR023937; IPR004843; IPR006186; "Bis(5'-nucleosyl)-tetraphosphatase PrpE [asymmetrical] (EC 3.6.1.17) (Ap4A hydrolase) (Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase) (Diadenosine tetraphosphatase)" prpE BH2845 Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) TR33990_c0_g1_i4 Q7N8V9 APAH_PHOLL 1.00E-11 GO:0008803 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity IPR004617; IPR004843; "Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC 3.6.1.41) (Ap4A hydrolase) (Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase) (Diadenosine tetraphosphatase)" apaH plu0607 Photorhabdus luminescens subsp. laumondii (strain TT01) TR33992_c2_g1_i1 Q1E5T3 CHL1_COCIM 2.00E-16 GO:0005524; GO:0004003; GO:0003677; GO:0007049; GO:0005634 ATP binding; ATP-dependent DNA helicase activity; DNA binding; cell cycle; nucleus IPR006555; IPR027076; IPR010614; IPR013020; IPR014013; IPR006554; IPR027417; ATP-dependent RNA helicase CHL1 (EC 3.6.4.13) (Chromosome loss protein 1) CHL1 CIMG_02080 Coccidioides immitis (strain RS) (Valley fever fungus) TR33992_c2_g2_i1 P0C928 RTEL1_DANRE 9.00E-67 GO:0051539; GO:0005524; GO:0004003; GO:0003677; GO:0006281; GO:0046872; GO:0005634 "4 iron, 4 sulfur cluster binding; ATP binding; ATP-dependent DNA helicase activity; DNA binding; DNA repair; metal ion binding; nucleus" IPR006555; IPR010614; IPR013020; IPR014013; IPR014001; IPR027417; Regulator of telomere elongation helicase 1 (EC 3.6.4.12) rtel1 Danio rerio (Zebrafish) (Brachydanio rerio) TR33992_c3_g1_i1 Q23808 AQP_CICVR 1.00E-32 GO:0016021; GO:0005215 integral to membrane; transporter activity IPR023271; IPR000425; Aquaporin AQPcic AQP CIC Cicadella viridis (Green leafhopper) TR33992_c3_g2_i1 Q25074 AQP_HAEIX 1.00E-30 GO:0016021; GO:0005215 integral to membrane; transporter activity IPR023271; IPR000425; IPR022357; Aquaporin (BfWC1) (Water channel 1) Haematobia irritans exigua (Buffalo fly) TR33992_c3_g2_i2 Q7XKI5 TIP32_ORYSJ 3.00E-27 GO:0016021; GO:0005215; GO:0005774 integral to membrane; transporter activity; vacuolar membrane IPR023271; IPR000425; IPR022357; Probable aquaporin TIP3-2 (Tonoplast intrinsic protein 3-2) (OsTIP3;2) TIP3-2 Os04g0527900 LOC_Os04g44570 OsJ_014891 OSJNBa0038O10.23 Oryza sativa subsp. japonica (Rice) TR33992_c7_g1_i1 Q16X92 RTEL1_AEDAE 5.00E-29 GO:0051539; GO:0005524; GO:0004003; GO:0003677; GO:0006281; GO:0046872; GO:0005634; GO:0010569 "4 iron, 4 sulfur cluster binding; ATP binding; ATP-dependent DNA helicase activity; DNA binding; DNA repair; metal ion binding; nucleus; regulation of double-strand break repair via homologous recombination" IPR006555; IPR010614; IPR013020; IPR014013; IPR014001; IPR027417; Regulator of telomere elongation helicase 1 homolog (EC 3.6.4.12) AAEL008960 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR33994_c0_g1_i2 Q92051 CAHZ_DANRE 5.00E-76 GO:0015670; GO:0004089; GO:0042539; GO:0006730; GO:0008270 carbon dioxide transport; carbonate dehydratase activity; hypotonic salinity response; one-carbon metabolic process; zinc ion binding IPR001148; IPR023561; IPR018338; Carbonic anhydrase (EC 4.2.1.1) (Carbonate dehydratase) cahz cah-z Danio rerio (Zebrafish) (Brachydanio rerio) TR33994_c0_g1_i4 Q92051 CAHZ_DANRE 1.00E-76 GO:0015670; GO:0004089; GO:0042539; GO:0006730; GO:0008270 carbon dioxide transport; carbonate dehydratase activity; hypotonic salinity response; one-carbon metabolic process; zinc ion binding IPR001148; IPR023561; IPR018338; Carbonic anhydrase (EC 4.2.1.1) (Carbonate dehydratase) cahz cah-z Danio rerio (Zebrafish) (Brachydanio rerio) TR33995_c0_g4_i2 Q5F478 ANR44_CHICK 2.00E-07 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) TR33996_c0_g1_i4 Q03IF2 RL4_STRTD 7.00E-10 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR002136; IPR013005; IPR023574; 50S ribosomal protein L4 rplD STER_1906 Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9) TR33996_c0_g1_i5 Q503X2 RM04_DANRE 2.00E-63 GO:0005739; GO:0005840; GO:0003735; GO:0006412 mitochondrion; ribosome; structural constituent of ribosome; translation IPR002136; IPR013005; IPR023574; "39S ribosomal protein L4, mitochondrial (L4mt) (MRP-L4)" mrpl4 zgc:110034 Danio rerio (Zebrafish) (Brachydanio rerio) TR33999_c0_g1_i3 Q9H2L4 TMM60_HUMAN 3.00E-15 GO:0016021 integral to membrane IPR019396; Transmembrane protein 60 TMEM60 C7orf35 DC32 Homo sapiens (Human) TR34003_c3_g1_i1 Q54PT1 GDAP2_DICDI 8.00E-43 IPR001251; IPR002589; Protein GDAP2 homolog gdap2 DDB_G0284349 Dictyostelium discoideum (Slime mold) TR34003_c3_g1_i2 A7T167 GDAP2_NEMVE 5.00E-147 IPR001251; IPR002589; Protein GDAP2 homolog gdap2 v1g195342 Nematostella vectensis (Starlet sea anemone) TR34003_c3_g1_i3 Q88SK6 Y3408_LACPL 1.00E-11 IPR002589; Macro domain-containing protein lp_3408 lp_3408 Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) TR34005_c3_g3_i1 Q6ZUK4 TMM26_HUMAN 5.00E-14 GO:0016021 integral to membrane IPR019169; Transmembrane protein 26 TMEM26 Homo sapiens (Human) TR34005_c3_g3_i3 Q90953 CSPG2_CHICK 5.00E-17 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Gallus gallus (Chicken) TR34007_c0_g1_i1 Q2KIP7 MD2L2_BOVIN 2.00E-58 GO:0042772; GO:0008432; GO:0051301; GO:0005737; GO:0006302; GO:0007067; GO:0060564; GO:0005634; GO:0033138; GO:0045893; GO:0001558; GO:0005819; GO:0006351; GO:0016035 "DNA damage response, signal transduction resulting in transcription; JUN kinase binding; cell division; cytoplasm; double-strand break repair; mitosis; negative regulation of mitotic anaphase-promoting complex activity; nucleus; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription, DNA-dependent; regulation of cell growth; spindle; transcription, DNA-dependent; zeta DNA polymerase complex" IPR003511; Mitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2) (MAD2-like protein 2) MAD2L2 Bos taurus (Bovine) TR34010_c0_g1_i2 Q7ZZ00 ZN511_DANRE 9.00E-39 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; Zinc finger protein 511 znf511 Danio rerio (Zebrafish) (Brachydanio rerio) TR34010_c0_g2_i1 Q5ZKH0 TF2H5_CHICK 2.00E-22 GO:0006281; GO:0000439; GO:0005654; GO:0006289; GO:0006355; GO:0006351 "DNA repair; core TFIIH complex; nucleoplasm; nucleotide-excision repair; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009400; General transcription factor IIH subunit 5 (General transcription factor IIH polypeptide 5) (TFB5 ortholog) (TFIIH basal transcription factor complex TTD-A subunit) GTF2H5 RCJMB04_10n20 Gallus gallus (Chicken) TR34011_c0_g1_i1 Q8N0V3 RBFA_HUMAN 2.00E-13 GO:0005739; GO:0006364 mitochondrion; rRNA processing IPR015946; IPR000238; IPR023799; IPR020053; "Putative ribosome-binding factor A, mitochondrial" RBFA C18orf22 Homo sapiens (Human) TR34013_c1_g1_i1 Q0P5Y3 TPPP2_MOUSE 1.00E-20 GO:0005509; GO:0005737 calcium ion binding; cytoplasm IPR011992; IPR008907; Tubulin polymerization-promoting protein family member 2 Tppp2 Gm77 Mus musculus (Mouse) TR34015_c6_g2_i1 Q8WXW3 PIBF1_HUMAN 6.00E-145 GO:0005813 centrosome IPR026205; Progesterone-induced-blocking factor 1 PIBF1 C13orf24 PIBF Homo sapiens (Human) TR34015_c7_g1_i3 Q8WXW3 PIBF1_HUMAN 2.00E-14 GO:0005813 centrosome IPR026205; Progesterone-induced-blocking factor 1 PIBF1 C13orf24 PIBF Homo sapiens (Human) TR34016_c1_g1_i1 Q4G0U5 PCDP1_HUMAN 4.00E-47 GO:0005929; GO:0060271; GO:0003341 cilium; cilium morphogenesis; cilium movement Primary ciliary dyskinesia protein 1 PCDP1 Homo sapiens (Human) TR34019_c0_g1_i1 Q8C5N5 PDD2L_MOUSE 5.00E-33 GO:0007049; GO:0005737 cell cycle; cytoplasm IPR007320; Programmed cell death protein 2-like Pdcd2l Mus musculus (Mouse) TR34020_c8_g5_i2 B1WAZ6 PA24A_XENTR 5.00E-42 GO:0016023; GO:0004622; GO:0046872; GO:0004623; GO:0009395 cytoplasmic membrane-bounded vesicle; lysophospholipase activity; metal ion binding; phospholipase A2 activity; phospholipid catabolic process IPR016035; IPR000008; IPR002642; Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] pla2g4a cpla2 pla2g4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34020_c8_g5_i3 B1WAZ6 PA24A_XENTR 1.00E-44 GO:0016023; GO:0004622; GO:0046872; GO:0004623; GO:0009395 cytoplasmic membrane-bounded vesicle; lysophospholipase activity; metal ion binding; phospholipase A2 activity; phospholipid catabolic process IPR016035; IPR000008; IPR002642; Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] pla2g4a cpla2 pla2g4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34022_c0_g1_i1 Q93X68 FABG5_BRANA 6.00E-42 GO:0004316; GO:0051287; GO:0009507; GO:0006633 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NAD binding; chloroplast; fatty acid biosynthetic process IPR011284; IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. "3-oxoacyl-[acyl-carrier-protein] reductase 5, chloroplastic (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase 5) (Fragment)" bkr1 Brassica napus (Rape) TR34022_c0_g1_i2 Q92506 DHB8_HUMAN 1.00E-72 GO:0003857; GO:0008209; GO:0004303; GO:0006703; GO:0006633; GO:0005740; GO:0005759; GO:0005886; GO:0047035 3-hydroxyacyl-CoA dehydrogenase activity; androgen metabolic process; estradiol 17-beta-dehydrogenase activity; estrogen biosynthetic process; fatty acid biosynthetic process; mitochondrial envelope; mitochondrial matrix; plasma membrane; testosterone dehydrogenase (NAD+) activity IPR002198; IPR002347; IPR016040; IPR020904; Steroid biosynthesis; estrogen biosynthesis. Lipid metabolism; fatty acid biosynthesis. Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Protein Ke6) (Ke-6) (Really interesting new gene 2 protein) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239) HSD17B8 FABGL HKE6 RING2 Homo sapiens (Human) TR34023_c0_g3_i1 A0JMK9 CAF1A_DANRE 1.00E-20 GO:0033186; GO:0006281; GO:0006260; GO:0007049; GO:0031497; GO:0005634; GO:0006355; GO:0006351 "CAF-1 complex; DNA repair; DNA replication; cell cycle; chromatin assembly; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR022043; Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-I p150) chaf1a caip150 ch211-129c21.3 zgc:153930 Danio rerio (Zebrafish) (Brachydanio rerio) TR34024_c2_g1_i1 Q5R3Z8 FBXL2_PONAB 2.00E-06 GO:0016020 membrane IPR001810; IPR006553; F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) FBXL2 FBL2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34024_c3_g1_i1 Q8WV35 LRC29_HUMAN 2.00E-11 Leucine-rich repeat-containing protein 29 (F-box and leucine-rich repeat protein 9) (F-box protein FBL9) (F-box/LRR-repeat protein 9) LRRC29 FBL9 FBXL9 Homo sapiens (Human) TR34024_c3_g1_i2 E1BNS0 FXL15_BOVIN 3.00E-11 GO:0000086; GO:0019005; GO:0031146; GO:0030282; GO:0005737; GO:0009953; GO:0030513; GO:0016567; GO:0004842 G2/M transition of mitotic cell cycle; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; bone mineralization; cytoplasm; dorsal/ventral pattern formation; positive regulation of BMP signaling pathway; protein ubiquitination; ubiquitin-protein ligase activity IPR001810; Protein modification; protein ubiquitination. F-box/LRR-repeat protein 15 FBXL15 Bos taurus (Bovine) TR34027_c0_g1_i3 O76924 ARI2_DROME 0 GO:0003676; GO:0005634; GO:0008270 nucleic acid binding; nucleus; zinc ion binding IPR002867; IPR001878; IPR001841; IPR013083; IPR017907; Protein ariadne-2 (Ari-2) ari-2 ari2 TRIAD1 CG5709 Drosophila melanogaster (Fruit fly) TR34029_c1_g1_i1 Q9J5H7 V024_FOWPN 5.00E-08 IPR002110; IPR020683; IPR018272; Putative ankyrin repeat protein FPV024 FPV024 Fowlpox virus (strain NVSL) (FPV) TR34029_c2_g1_i5 Q5ZM55 FEM1B_CHICK 8.00E-08 GO:0006915; GO:0005737; GO:0005634; GO:0016567; GO:2000001 apoptotic process; cytoplasm; nucleus; protein ubiquitination; regulation of DNA damage checkpoint IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog B (FEM1b) (FEM1-beta) FEM1B RCJMB04_3b14 Gallus gallus (Chicken) TR34030_c0_g1_i1 Q8HXX9 FRDA_MACFA 1.00E-37 GO:0006879; GO:0008199; GO:0004322; GO:0006783; GO:0006811; GO:0016226; GO:0005739 cellular iron ion homeostasis; ferric iron binding; ferroxidase activity; heme biosynthetic process; ion transport; iron-sulfur cluster assembly; mitochondrion IPR017789; IPR002908; IPR020895; "Frataxin, mitochondrial (Fxn) (EC 1.16.3.1) [Cleaved into: Frataxin intermediate form; Frataxin mature form]" FXN FRDA1 QnpA-13971 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR34030_c0_g1_i3 Q05B87 FRDA_BOVIN 1.00E-36 GO:0051537; GO:0007628; GO:0009060; GO:0006879; GO:0070301; GO:0005829; GO:0009792; GO:0008199; GO:0008198; GO:0004322; GO:0006783; GO:0006811; GO:0034986; GO:0018283; GO:0005739; GO:0007005; GO:0043066; GO:0040015; GO:0046621; GO:0090201; GO:0006119; GO:0030307; GO:0008284; GO:0051349; GO:0048554; GO:0051353; GO:0051347; GO:0019230; GO:0016540; GO:0010722; GO:0010039 "2 iron, 2 sulfur cluster binding; adult walking behavior; aerobic respiration; cellular iron ion homeostasis; cellular response to hydrogen peroxide; cytosol; embryo development ending in birth or egg hatching; ferric iron binding; ferrous iron binding; ferroxidase activity; heme biosynthetic process; ion transport; iron chaperone activity; iron incorporation into metallo-sulfur cluster; mitochondrion; mitochondrion organization; negative regulation of apoptotic process; negative regulation of multicellular organism growth; negative regulation of organ growth; negative regulation of release of cytochrome c from mitochondria; oxidative phosphorylation; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of lyase activity; positive regulation of metalloenzyme activity; positive regulation of oxidoreductase activity; positive regulation of transferase activity; proprioception; protein autoprocessing; regulation of ferrochelatase activity; response to iron ion" IPR017789; IPR002908; IPR020895; "Frataxin, mitochondrial (Fxn) (EC 1.16.3.1) [Cleaved into: Frataxin intermediate form; Frataxin mature form]" FXN FRDA Bos taurus (Bovine) TR34030_c0_g1_i4 O35943 FRDA_MOUSE 2.00E-39 GO:0051537; GO:0007628; GO:0009060; GO:0006879; GO:0070301; GO:0005829; GO:0009792; GO:0008199; GO:0008198; GO:0004322; GO:0006783; GO:0006811; GO:0034986; GO:0018283; GO:0016226; GO:0005739; GO:0007005; GO:0043066; GO:0040015; GO:0046621; GO:0090201; GO:0006119; GO:0030307; GO:0008284; GO:0051349; GO:0048554; GO:0051353; GO:0051347; GO:0019230; GO:0016540; GO:0010722; GO:0010039 "2 iron, 2 sulfur cluster binding; adult walking behavior; aerobic respiration; cellular iron ion homeostasis; cellular response to hydrogen peroxide; cytosol; embryo development ending in birth or egg hatching; ferric iron binding; ferrous iron binding; ferroxidase activity; heme biosynthetic process; ion transport; iron chaperone activity; iron incorporation into metallo-sulfur cluster; iron-sulfur cluster assembly; mitochondrion; mitochondrion organization; negative regulation of apoptotic process; negative regulation of multicellular organism growth; negative regulation of organ growth; negative regulation of release of cytochrome c from mitochondria; oxidative phosphorylation; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of lyase activity; positive regulation of metalloenzyme activity; positive regulation of oxidoreductase activity; positive regulation of transferase activity; proprioception; protein autoprocessing; regulation of ferrochelatase activity; response to iron ion" IPR017789; IPR002908; IPR020895; "Frataxin, mitochondrial (Fxn) (EC 1.16.3.1) [Cleaved into: Frataxin intermediate form; Frataxin mature form]" Fxn Frda Mus musculus (Mouse) TR34032_c1_g1_i2 Q8TDB6 DTX3L_HUMAN 3.00E-51 GO:0005737; GO:0006302; GO:0042393; GO:0010390; GO:0005634; GO:0004842; GO:0008270 cytoplasm; double-strand break repair; histone binding; histone monoubiquitination; nucleus; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) TR34033_c1_g1_i4 P20250 PA2A_PSEAU 4.00E-13 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Acidic phospholipase A2 PA-1G (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) Pseudechis australis (Mulga snake) (King brown snake) TR34033_c1_g1_i6 P59067 PA2SA_AUSSU 4.00E-06 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Phospholipase A2 superbin a (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (Fragment) Austrelaps superbus (Lowland copperhead snake) (Hoplocephalus superbus) TR34035_c4_g2_i1 Q92963 RIT1_HUMAN 2.00E-69 GO:0005525; GO:0003924; GO:0007265; GO:0005516; GO:0048011; GO:0005886 Q13129 GTP binding; GTPase activity; Ras protein signal transduction; calmodulin binding; neurotrophin TRK receptor signaling pathway; plasma membrane IPR027417; IPR005225; IPR001806; IPR020849; GTP-binding protein Rit1 (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1) RIT1 RIBB RIT ROC1 Homo sapiens (Human) TR34036_c0_g1_i2 O89113 IER5_MOUSE 5.00E-07 IPR008653; Immediate early response gene 5 protein Ier5 Mus musculus (Mouse) TR34038_c0_g1_i1 Q00232 NU5M_MYTED 0 GO:0042773; GO:0008137; GO:0016021; GO:0005743; GO:0070469 ATP synthesis coupled electron transport; NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial inner membrane; respiratory chain IPR010934; IPR001750; IPR001516; NADH-ubiquinone oxidoreductase chain 5 (EC 1.6.5.3) (NADH dehydrogenase subunit 5) ND5 Mytilus edulis (Blue mussel) TR34038_c0_g1_i2 Q00230 NU4LM_MYTED 6.00E-31 GO:0042773; GO:0008137; GO:0016021; GO:0031966; GO:0070469 ATP synthesis coupled electron transport; NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial membrane; respiratory chain IPR001133; NADH-ubiquinone oxidoreductase chain 4L (EC 1.6.5.3) (NADH dehydrogenase subunit 4L) ND4L Mytilus edulis (Blue mussel) TR34038_c0_g4_i1 Q00570 NU6M_MYTED 2.00E-25 GO:0008137; GO:0016021; GO:0031966; GO:0070469 NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial membrane; respiratory chain IPR001457; NADH-ubiquinone oxidoreductase chain 6 (EC 1.6.5.3) (NADH dehydrogenase subunit 6) ND6 Mytilus edulis (Blue mussel) TR34039_c0_g1_i1 Q66J52 S226B_XENLA 8.00E-11 GO:0016021; GO:0015075; GO:0005886 integral to membrane; ion transmembrane transporter activity; plasma membrane IPR020846; IPR016196; IPR004749; IPR005828; Solute carrier family 22 member 6-B (Organic cation transporter 1-B) (Renal organic anion transporter 1-B) (ROAT1-B) slc22a6-b oat1-b Xenopus laevis (African clawed frog) TR34039_c2_g1_i1 Q9VCA2 ORCT_DROME 9.00E-18 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR34039_c5_g1_i1 P14381 YTX2_XENLA 3.00E-17 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR34041_c1_g1_i1 Q4QRH7 PEX16_DANRE 8.00E-78 GO:0016021; GO:0005778; GO:0007031 integral to membrane; peroxisomal membrane; peroxisome organization IPR013919; Peroxisomal membrane protein PEX16 (Peroxin-16) (Peroxisomal biogenesis factor 16) pex16 zgc:112248 Danio rerio (Zebrafish) (Brachydanio rerio) TR34041_c1_g1_i3 Q8S8S1 PEX16_ARATH 4.00E-09 GO:0005789; GO:0006633; GO:0016021; GO:0005778; GO:0005777; GO:0007031 endoplasmic reticulum membrane; fatty acid biosynthetic process; integral to membrane; peroxisomal membrane; peroxisome; peroxisome organization IPR013919; Peroxisome biogenesis protein 16 (Peroxin-16) (AtPEX16) (AtPex16p) (Protein SHRUNKEN SEED 1) PEX16 SSE1 At2g45690 F17K2.22 Arabidopsis thaliana (Mouse-ear cress) TR34043_c0_g1_i1 P39078 TCPD_YEAST 4.00E-50 GO:0005524; GO:0005832; GO:0006457; GO:0051082 ATP binding; chaperonin-containing T-complex; protein folding; unfolded protein binding IPR012717; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) CCT4 ANC2 TCP4 YDL143W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR34043_c0_g2_i6 Q4R6V2 TCPE_MACFA 1.00E-178 GO:0005524; GO:0005737; GO:0005815; GO:0006457 ATP binding; cytoplasm; microtubule organizing center; protein folding IPR012718; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon) CCT5 QtsA-17059 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR34045_c0_g1_i3 Q8N635 MEIOB_HUMAN 3.00E-61 GO:0005737; GO:0007140 cytoplasm; male meiosis IPR012340; Meiosis-specific with OB domain-containing protein MEIOB C16orf73 Homo sapiens (Human) TR34046_c0_g1_i2 Q9NV56 MRGBP_HUMAN 7.00E-25 GO:0043189; GO:0016568; GO:0005634; GO:0040008; GO:0006355; GO:0006351 "H4/H2A histone acetyltransferase complex; chromatin modification; nucleus; regulation of growth; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR012423; MRG/MORF4L-binding protein (MRG-binding protein) MRGBP C20orf20 Homo sapiens (Human) TR34046_c0_g1_i3 Q6BKL0 EAF7_DEBHA 7.00E-08 GO:0006281; GO:0043189; GO:0016568; GO:0006355; GO:0006351 "DNA repair; H4/H2A histone acetyltransferase complex; chromatin modification; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR012423; Chromatin modification-related protein EAF7 EAF7 DEHA2F20966g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR34047_c2_g1_i1 P41436 IAP_GVCPM 8.00E-31 GO:0006915; GO:0008270 apoptotic process; zinc ion binding IPR001370; IPR001841; Apoptosis inhibitor IAP IAP Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) TR34047_c2_g1_i3 A9JTP3 BIRC7_XENTR 2.00E-29 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP) (Embryonic/Egg IAP) (EIAP/XLX) birc7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34047_c2_g1_i5 P41436 IAP_GVCPM 2.00E-31 GO:0006915; GO:0008270 apoptotic process; zinc ion binding IPR001370; IPR001841; Apoptosis inhibitor IAP IAP Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) TR34047_c2_g1_i6 A5D8Q0 XIAP_XENLA 9.00E-25 GO:0016055; GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0045861; GO:0090263; GO:0008270 Wnt receptor signaling pathway; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; negative regulation of proteolysis; positive regulation of canonical Wnt receptor signaling pathway; zinc ion binding IPR001370; IPR001841; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (xXIAP) xiap birc4 Xenopus laevis (African clawed frog) TR34049_c3_g1_i1 Q8N8K9 K1958_HUMAN 3.00E-14 IPR021893; Uncharacterized protein KIAA1958 KIAA1958 Homo sapiens (Human) TR34050_c0_g1_i1 Q9P243 ZFAT_HUMAN 6.00E-11 GO:0003677; GO:0001077; GO:0005829; GO:0002244; GO:0046872; GO:0005634; GO:0060712 DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; cytosol; hematopoietic progenitor cell differentiation; metal ion binding; nucleus; spongiotrophoblast layer development IPR007087; IPR015880; IPR013087; Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) ZFAT KIAA1485 ZFAT1 ZNF406 Homo sapiens (Human) TR34051_c0_g1_i1 Q5R5V9 VPS72_PONAB 9.00E-30 GO:0003677; GO:0016568; GO:0005634; GO:0043234; GO:0006355; GO:0035019; GO:0006351 "DNA binding; chromatin modification; nucleus; protein complex; regulation of transcription, DNA-dependent; somatic stem cell maintenance; transcription, DNA-dependent" IPR008895; IPR013272; Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) VPS72 TCFL1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34052_c1_g1_i1 P28824 NRP1_XENLA 4.00E-14 GO:0001525; GO:0007411; GO:0007155; GO:0035767; GO:0008201; GO:0016021; GO:0046872; GO:0009887; GO:0017154; GO:0048010; GO:0005021 angiogenesis; axon guidance; cell adhesion; endothelial cell chemotaxis; heparin binding; integral to membrane; metal ion binding; organ morphogenesis; semaphorin receptor activity; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor-activated receptor activity IPR000421; IPR008985; IPR000859; IPR008979; IPR000998; IPR014648; IPR022579; IPR027146; Neuropilin-1 (A5 antigen) (A5 protein) nrp1 Xenopus laevis (African clawed frog) TR34052_c1_g1_i2 Q7Z304 MAMC2_HUMAN 4.00E-19 GO:0005783; GO:0005539; GO:0005614; GO:0016020; GO:0019800 endoplasmic reticulum; glycosaminoglycan binding; interstitial matrix; membrane; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IPR008985; IPR000998; MAM domain-containing protein 2 (MAM domain-containing proteoglycan) (Mamcan) MAMDC2 Homo sapiens (Human) TR34052_c1_g1_i4 Q91641 THIB_XENLA 1.00E-20 GO:0005615; GO:0016020; GO:0007275 extracellular space; membrane; multicellular organismal development IPR008985; IPR000998; Thyroid hormone-induced protein B Xenopus laevis (African clawed frog) TR34052_c1_g1_i5 Q63191 AEGP_RAT 4.00E-18 GO:0005768; GO:0016021; GO:0015031 endosome; integral to membrane; protein transport IPR008985; IPR023415; IPR002172; IPR000998; Apical endosomal glycoprotein (MAM domain-containing protein 4) Mamdc4 Aegp Rattus norvegicus (Rat) TR34052_c1_g1_i6 Q7Z304 MAMC2_HUMAN 5.00E-15 GO:0005783; GO:0005539; GO:0005614; GO:0016020; GO:0019800 endoplasmic reticulum; glycosaminoglycan binding; interstitial matrix; membrane; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IPR008985; IPR000998; MAM domain-containing protein 2 (MAM domain-containing proteoglycan) (Mamcan) MAMDC2 Homo sapiens (Human) TR34053_c1_g1_i1 Q9D7X3 DUS3_MOUSE 2.00E-19 GO:0033549; GO:0005829; GO:0001772; GO:0070373; GO:0046329; GO:0050868; GO:0050860; GO:0005654; GO:0045931; GO:0006470; GO:0004725; GO:0008138 MAP kinase phosphatase activity; cytosol; immunological synapse; negative regulation of ERK1 and ERK2 cascade; negative regulation of JNK cascade; negative regulation of T cell activation; negative regulation of T cell receptor signaling pathway; nucleoplasm; positive regulation of mitotic cell cycle; protein dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR020417; IPR020405; IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (T-DSP11) (Vaccinia H1-related phosphatase) (VHR) Dusp3 Mus musculus (Mouse) TR34056_c3_g2_i1 P50107 LGUL_YEAST 2.00E-36 GO:0006749; GO:0004462; GO:0046872; GO:0019243 glutathione metabolic process; lactoylglutathione lyase activity; metal ion binding; methylglyoxal catabolic process to D-lactate IPR004360; IPR025870; IPR004361; IPR018146; Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2. Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) GLO1 YML004C YM9571.15C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR34056_c3_g2_i2 Q6P7Q4 LGUL_RAT 2.00E-88 GO:0005975; GO:0006749; GO:0004462; GO:0046872; GO:0009438; GO:0043066; GO:0006357 carbohydrate metabolic process; glutathione metabolic process; lactoylglutathione lyase activity; metal ion binding; methylglyoxal metabolic process; negative regulation of apoptotic process; regulation of transcription from RNA polymerase II promoter IPR004360; IPR004361; IPR018146; Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2. Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) Glo1 Rattus norvegicus (Rat) TR34056_c3_g2_i4 Q42891 LGUL_SOLLC 1.00E-74 GO:0009507; GO:0005829; GO:0006094; GO:0006096; GO:0004462; GO:0046872; GO:0046686; GO:0009651 chloroplast; cytosol; gluconeogenesis; glycolysis; lactoylglutathione lyase activity; metal ion binding; response to cadmium ion; response to salt stress IPR004360; IPR004361; IPR018146; Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2. Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) GLX1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) TR34057_c8_g2_i1 Q8R1K4 AT2L2_MOUSE 1.00E-122 GO:0016829; GO:0008152; GO:0005739; GO:0030170; GO:0008483 lyase activity; metabolic process; mitochondrion; pyridoxal phosphate binding; transaminase activity IPR005814; IPR015424; IPR015421; IPR015422; 5-phosphohydroxy-L-lysine phospho-lyase (EC 4.2.3.134) (Alanine--glyoxylate aminotransferase 2-like 2) Phykpl Agxt2l2 Mus musculus (Mouse) TR34060_c1_g1_i2 O08747 UNC5C_MOUSE 2.00E-16 GO:0033564; GO:0006915; GO:0007420; GO:0016021; GO:0005042; GO:0005886; GO:0043065; GO:0030334 anterior/posterior axon guidance; apoptotic process; brain development; integral to membrane; netrin receptor activity; plasma membrane; positive regulation of apoptotic process; regulation of cell migration IPR011029; IPR000488; IPR007110; IPR013783; IPR013098; IPR003598; IPR000884; IPR000906; Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C) (Rostral cerebellar malformation protein) Unc5c Rcm Unc5h3 Mus musculus (Mouse) TR34060_c1_g2_i1 Q69Z28 ATS16_MOUSE 3.00E-12 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16) (EC 3.4.24.-) Adamts16 Kiaa2029 Mus musculus (Mouse) TR34060_c2_g2_i1 O15072 ATS3_HUMAN 3.00E-07 GO:0030574; GO:0030199; GO:0008201; GO:0004222; GO:0016485; GO:0005578; GO:0006508; GO:0008270 collagen catabolic process; collagen fibril organization; heparin binding; metalloendopeptidase activity; protein processing; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAM-TS 3) (ADAM-TS3) (ADAMTS-3) (EC 3.4.24.-) (Procollagen II N-proteinase) (PC II-NP) (Procollagen II amino propeptide-processing enzyme) ADAMTS3 KIAA0366 Homo sapiens (Human) TR34060_c2_g2_i10 P59510 ATS20_HUMAN 4.00E-06 GO:0030198; GO:0005615; GO:0004222; GO:0043066; GO:0045636; GO:0009967; GO:0005578; GO:0006508; GO:0008270 extracellular matrix organization; extracellular space; metalloendopeptidase activity; negative regulation of apoptotic process; positive regulation of melanocyte differentiation; positive regulation of signal transduction; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR012314; IPR001590; IPR013273; IPR002870; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAM-TS 20) (ADAM-TS20) (ADAMTS-20) (EC 3.4.24.-) ADAMTS20 Homo sapiens (Human) TR34060_c2_g2_i11 Q96RW7 HMCN1_HUMAN 8.00E-39 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR34060_c2_g2_i3 Q64181 PROP_CAVPO 6.00E-21 GO:0006957; GO:0005576 "complement activation, alternative pathway; extracellular region" IPR000884; Properdin (Complement factor P) CFP PFC Cavia porcellus (Guinea pig) TR34060_c2_g2_i7 Q811B3 ATS12_MOUSE 4.00E-09 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAM-TS 12) (ADAM-TS12) (ADAMTS-12) (EC 3.4.24.-) Adamts12 Mus musculus (Mouse) TR34060_c2_g2_i9 Q96RW7 HMCN1_HUMAN 2.00E-42 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR34060_c3_g1_i1 Q761X5 UNC5C_RAT 2.00E-17 GO:0006915; GO:0016021; GO:0007275; GO:0007165 apoptotic process; integral to membrane; multicellular organismal development; signal transduction IPR011029; IPR000488; IPR007110; IPR013783; IPR013098; IPR003598; IPR000884; IPR000906; Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C) Unc5c Unc5h3 Rattus norvegicus (Rat) TR34060_c3_g1_i11 Q8K1S4 UNC5A_MOUSE 1.00E-18 GO:0033564; GO:0006915; GO:0005829; GO:0016021; GO:0005886; GO:0007165 anterior/posterior axon guidance; apoptotic process; cytosol; integral to membrane; plasma membrane; signal transduction IPR011029; IPR000488; IPR007110; IPR013783; IPR013098; IPR003599; IPR000884; IPR000906; Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A) Unc5a Kiaa1976 Unc5h1 Mus musculus (Mouse) TR34060_c3_g1_i3 P57110 ATS8_MOUSE 3.00E-07 GO:0008201; GO:0004222; GO:0005578; GO:0006508; GO:0008270 heparin binding; metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR013277; IPR001590; IPR013273; IPR002870; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAM-TS 8) (ADAM-TS8) (ADAMTS-8) (EC 3.4.24.-) (METH-2) Adamts8 Mus musculus (Mouse) TR34060_c3_g1_i4 P35440 TSP2_CHICK 3.00E-31 GO:0005604; GO:0005509; GO:0007155; GO:0008201; GO:0016525 basement membrane; calcium ion binding; cell adhesion; heparin binding; negative regulation of angiogenesis IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR024731; IPR001791; IPR000884; IPR015455; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-2 THBS2 TSP2 Gallus gallus (Chicken) TR34060_c3_g1_i5 Q3UHD1 BAI1_MOUSE 9.00E-24 GO:0004930; GO:0016021; GO:0016525; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; negative regulation of angiogenesis; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR008077; IPR001879; IPR000832; IPR000203; IPR000884; Brain-specific angiogenesis inhibitor 1 Bai1 Mus musculus (Mouse) TR34060_c3_g1_i6 Q8TE57 ATS16_HUMAN 2.00E-08 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16) (EC 3.4.24.-) ADAMTS16 KIAA2029 Homo sapiens (Human) TR34060_c3_g1_i7 P35447 SPON1_XENLA 2.00E-10 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR002861; IPR009465; IPR000884; Spondin-1 (F-spondin) spon1 Xenopus laevis (African clawed frog) TR34062_c2_g2_i1 P00973 OAS1_HUMAN 6.00E-14 GO:0001730; GO:0005524; GO:0035457; GO:0005737; GO:0005829; GO:0051607; GO:0003725; GO:0005783; GO:0005576; GO:0060333; GO:0046872; GO:0005739; GO:0045071; GO:0005634; GO:0051259; GO:0006164; GO:0060700; GO:0009615; GO:0060337; GO:0008270 Q96LA8 2'-5'-oligoadenylate synthetase activity; ATP binding; cellular response to interferon-alpha; cytoplasm; cytosol; defense response to virus; double-stranded RNA binding; endoplasmic reticulum; extracellular region; interferon-gamma-mediated signaling pathway; metal ion binding; mitochondrion; negative regulation of viral genome replication; nucleus; protein oligomerization; purine nucleotide biosynthetic process; regulation of ribonuclease activity; response to virus; type I interferon-mediated signaling pathway; zinc ion binding IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 1 ((2-5')oligo(A) synthase 1) (2-5A synthase 1) (EC 2.7.7.84) (E18/E16) (p46/p42 OAS) OAS1 OIAS Homo sapiens (Human) TR34062_c3_g1_i1 Q8HXX6 SAP3_MACFA 1.00E-19 GO:0016787; GO:0005764; GO:0006665 hydrolase activity; lysosome; sphingolipid metabolic process IPR003172; Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) GM2A QccE-17591 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR34062_c3_g1_i2 Q8HXX6 SAP3_MACFA 2.00E-19 GO:0016787; GO:0005764; GO:0006665 hydrolase activity; lysosome; sphingolipid metabolic process IPR003172; Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) GM2A QccE-17591 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR34062_c5_g1_i10 Q5MYT9 OASL2_RAT 1.00E-16 GO:0001730; GO:0005524; GO:0051607; GO:0003725; GO:0045087; GO:0046872; GO:0006164; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; defense response to virus; double-stranded RNA binding; innate immune response; metal ion binding; purine nucleotide biosynthetic process; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR022617; IPR000626; 2'-5'-oligoadenylate synthase-like protein 2 (EC 2.7.7.84) Oasl2 Rattus norvegicus (Rat) TR34062_c5_g1_i4 Q05961 OAS1A_RAT 5.00E-24 GO:0001730; GO:0005524; GO:0051607; GO:0003725; GO:0005783; GO:0045087; GO:0046872; GO:0005739; GO:0005634; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; defense response to virus; double-stranded RNA binding; endoplasmic reticulum; innate immune response; metal ion binding; mitochondrion; nucleus; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 1A ((2-5')oligo(A) synthase 1A) (2-5A synthase 1A) (EC 2.7.7.84) Oas1a Oas1 Rattus norvegicus (Rat) TR34062_c5_g1_i7 Q5MYT9 OASL2_RAT 6.00E-25 GO:0001730; GO:0005524; GO:0051607; GO:0003725; GO:0045087; GO:0046872; GO:0006164; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; defense response to virus; double-stranded RNA binding; innate immune response; metal ion binding; purine nucleotide biosynthetic process; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR022617; IPR000626; 2'-5'-oligoadenylate synthase-like protein 2 (EC 2.7.7.84) Oasl2 Rattus norvegicus (Rat) TR34062_c5_g1_i8 P29728 OAS2_HUMAN 8.00E-20 GO:0001730; GO:0005524; GO:0006401; GO:0005737; GO:0005829; GO:0051607; GO:0003725; GO:0005783; GO:0060333; GO:0043231; GO:0016020; GO:0046872; GO:0005739; GO:0006139; GO:0005634; GO:0048471; GO:0006486; GO:0018377; GO:0006164; GO:0009615; GO:0060337; GO:0008270 2'-5'-oligoadenylate synthetase activity; ATP binding; RNA catabolic process; cytoplasm; cytosol; defense response to virus; double-stranded RNA binding; endoplasmic reticulum; interferon-gamma-mediated signaling pathway; intracellular membrane-bounded organelle; membrane; metal ion binding; mitochondrion; nucleobase-containing compound metabolic process; nucleus; perinuclear region of cytoplasm; protein glycosylation; protein myristoylation; purine nucleotide biosynthetic process; response to virus; type I interferon-mediated signaling pathway; zinc ion binding IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (p69 OAS / p71 OAS) (p69OAS / p71OAS) OAS2 Homo sapiens (Human) TR34066_c10_g3_i2 Q80V70 MEGF6_MOUSE 2.00E-28 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR013111; IPR002049; IPR011489; IPR009030; Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) TR34066_c10_g3_i4 A0JM12 MEG10_XENTR 6.00E-30 GO:0007155; GO:0016021; GO:0006909; GO:0005886; GO:0014719; GO:0014816; GO:0014841 cell adhesion; integral to membrane; phagocytosis; plasma membrane; satellite cell activation; satellite cell differentiation; satellite cell proliferation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34066_c11_g1_i1 Q96JB1 DYH8_HUMAN 1.00E-79 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 8, axonemal (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8)" DNAH8 Homo sapiens (Human) TR34066_c14_g1_i1 Q8VHE6 DYH5_MOUSE 9.00E-90 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 5, axonemal (Axonemal beta dynein heavy chain 5) (mDNAH5) (Ciliary dynein heavy chain 5)" Dnah5 Dnahc5 Mus musculus (Mouse) TR34066_c2_g1_i1 Q9P2D7 DYH1_HUMAN 2.00E-21 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018; GO:0009612 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement; response to mechanical stimulus IPR011704; IPR026983; IPR026975; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 1, axonemal (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1) (Heat shock regulated protein 1) (HSRF-1) (hDHC7)" DNAH1 DHC7 DNAHC1 KIAA1410 Homo sapiens (Human) TR34066_c6_g1_i1 Q8VHE6 DYH5_MOUSE 7.00E-66 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 5, axonemal (Axonemal beta dynein heavy chain 5) (mDNAH5) (Ciliary dynein heavy chain 5)" Dnah5 Dnahc5 Mus musculus (Mouse) TR34066_c7_g1_i1 Q9NYC9 DYH9_HUMAN 2.00E-18 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0030030; GO:0006928; GO:0035085; GO:0005874; GO:0003777; GO:0007018; GO:0007283 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; cell projection organization; cellular component movement; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement; spermatogenesis IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 9, axonemal (Axonemal beta dynein heavy chain 9) (Ciliary dynein heavy chain 9)" DNAH9 DNAH17L DNAL1 KIAA0357 Homo sapiens (Human) TR34066_c7_g1_i2 Q39565 DYHB_CHLRE 3.00E-18 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein beta chain, flagellar outer arm" ODA4 ODA-4 SUP1 Chlamydomonas reinhardtii (Chlamydomonas smithii) TR34066_c8_g1_i2 Q9CZ09 MET18_MOUSE 3.00E-54 GO:0005737; GO:0008276 cytoplasm; protein methyltransferase activity IPR010456; Histidine protein methyltransferase 1 homolog (Methyltransferase-like protein 18) (EC 2.1.1.-) Mettl18 Mus musculus (Mouse) TR34066_c9_g2_i1 Q3MHH4 SYQ_BOVIN 2.00E-25 GO:0005524; GO:0005737; GO:0004819; GO:0006425 ATP binding; cytoplasm; glutamine-tRNA ligase activity; glutaminyl-tRNA aminoacylation IPR001412; IPR004514; IPR007638; IPR007639; IPR000924; IPR020061; IPR020058; IPR020059; IPR020056; IPR011035; IPR014729; Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS) QARS Bos taurus (Bovine) TR34067_c3_g1_i3 Q02970 FABP1_ECHGR 6.00E-07 GO:0008289; GO:0005215 lipid binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; Fatty acid-binding protein homolog 1 (EgDf1) (EgFABP1) FABP1 DF1 Echinococcus granulosus TR34067_c3_g1_i4 A6YLM6 FABP4_CEREL 4.00E-17 GO:0005737; GO:0008289; GO:0005634; GO:0005215 cytoplasm; lipid binding; nucleus; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; "Fatty acid-binding protein, adipocyte (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4)" FABP4 Cervus elaphus (Red deer) TR34068_c1_g1_i9 Q1KME6 RAB6A_CHICK 4.00E-09 GO:0005525; GO:0003924; GO:0000139; GO:0022402; GO:0005813; GO:0000042; GO:0010824; GO:0042493; GO:0007264 GTP binding; GTPase activity; Golgi membrane; cell cycle process; centrosome; protein targeting to Golgi; regulation of centrosome duplication; response to drug; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-6A RAB6A Gallus gallus (Chicken) TR34070_c2_g2_i1 Q9FFK8 NFXL2_ARATH 6.00E-23 GO:0016021; GO:0016874; GO:0005634; GO:0016567; GO:0010310; GO:0009651; GO:0048511; GO:0003700; GO:0008270 integral to membrane; ligase activity; nucleus; protein ubiquitination; regulation of hydrogen peroxide metabolic process; response to salt stress; rhythmic process; sequence-specific DNA binding transcription factor activity; zinc ion binding IPR019786; IPR000967; IPR001841; Protein modification; protein ubiquitination. NF-X1-type zinc finger protein NFXL2 (AtNFXL2) (EC 6.3.2.-) (Protein EARLY BIRD) NFXL2 EBI At5g05660 MJJ3.6 Arabidopsis thaliana (Mouse-ear cress) TR34070_c2_g4_i1 Q6ZNB6 NFXL1_HUMAN 3.00E-52 GO:0016021; GO:0005634; GO:0003700; GO:0008270 integral to membrane; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding IPR019786; IPR000967; IPR001841; NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) NFXL1 OZFP Homo sapiens (Human) TR34070_c5_g2_i3 Q6ZNB6 NFXL1_HUMAN 2.00E-22 GO:0016021; GO:0005634; GO:0003700; GO:0008270 integral to membrane; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding IPR019786; IPR000967; IPR001841; NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) NFXL1 OZFP Homo sapiens (Human) TR34072_c0_g1_i2 Q4R8A8 TMM97_MACFA 2.00E-42 GO:0042632; GO:0016021; GO:0005764; GO:0031965; GO:0005886; GO:0005791 cholesterol homeostasis; integral to membrane; lysosome; nuclear membrane; plasma membrane; rough endoplasmic reticulum IPR016964; Transmembrane protein 97 Tmem97 QtsA-12948 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR34072_c0_g1_i5 Q6DFQ5 TMM97_XENTR 7.00E-44 GO:0042632; GO:0016021; GO:0005764; GO:0031965; GO:0005886; GO:0005791 cholesterol homeostasis; integral to membrane; lysosome; nuclear membrane; plasma membrane; rough endoplasmic reticulum IPR016964; Transmembrane protein 97 tmem97 TEgg113g04.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34072_c0_g1_i6 Q12155 YL050_YEAST 2.00E-07 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR016964; Uncharacterized membrane protein YLR050C YLR050C L2125 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR34073_c0_g1_i1 Q5EB14 SWET1_DANRE 4.00E-15 GO:0000139; GO:0016021; GO:0005886; GO:0051119 Golgi membrane; integral to membrane; plasma membrane; sugar transmembrane transporter activity IPR004316; Sugar transporter SWEET1 (RAG1-activating protein 1) (Solute carrier family 50 member 1) slc50a1 rag1ap1 zgc:113092 Danio rerio (Zebrafish) (Brachydanio rerio) TR34075_c2_g1_i1 P33450 FAT_DROME 9.00E-08 GO:0005509; GO:0016339; GO:0050839; GO:0030054; GO:0000904; GO:0008283; GO:0045317; GO:0048105; GO:0045198; GO:0001737; GO:0035329; GO:0007156; GO:0007446; GO:0005887; GO:0090176; GO:0030178; GO:0008285; GO:0045571; GO:0016318; GO:0018149; GO:0004872; GO:0035159 "calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; cell junction; cell morphogenesis involved in differentiation; cell proliferation; equator specification; establishment of body hair planar orientation; establishment of epithelial cell apical/basal polarity; establishment of imaginal disc-derived wing hair orientation; hippo signaling cascade; homophilic cell adhesion; imaginal disc growth; integral to plasma membrane; microtubule cytoskeleton organization involved in establishment of planar polarity; negative regulation of Wnt receptor signaling pathway; negative regulation of cell proliferation; negative regulation of imaginal disc growth; ommatidial rotation; peptide cross-linking; receptor activity; regulation of tube length, open tracheal system" IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR013032; IPR001791; Cadherin-related tumor suppressor (Protein fat) ft CG3352 Drosophila melanogaster (Fruit fly) TR34075_c3_g1_i1 Q61555 FBN2_MOUSE 2.00E-79 GO:0060346; GO:0005509; GO:0030326; GO:0005201; GO:0001527; GO:0030501; GO:0045669; GO:0035583 bone trabecula formation; calcium ion binding; embryonic limb morphogenesis; extracellular matrix structural constituent; microfibril; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; sequestering of TGFbeta in extracellular matrix IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR011398; IPR009030; IPR017878; Fibrillin-2 Fbn2 Fbn-2 Mus musculus (Mouse) TR34075_c4_g1_i1 Q9TV36 FBN1_PIG 9.00E-70 GO:0005509; GO:0005201; GO:0005578 calcium ion binding; extracellular matrix structural constituent; proteinaceous extracellular matrix IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR011398; IPR009030; IPR017878; Fibrillin-1 FBN1 Sus scrofa (Pig) TR34075_c4_g3_i1 Q29FE9 CUE_DROPS 5.00E-07 GO:0030154; GO:0016021; GO:0048477; GO:0005886; GO:0007283 cell differentiation; integral to membrane; oogenesis; plasma membrane; spermatogenesis IPR011042; IPR000742; IPR013032; IPR000033; Protein cueball cue GA11386 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR34076_c0_g1_i1 Q3MIT2 PUS10_HUMAN 6.00E-133 GO:0003723; GO:0009982; GO:0001522; GO:0008033 RNA binding; pseudouridine synthase activity; pseudouridine synthesis; tRNA processing IPR020103; Putative tRNA pseudouridine synthase Pus10 (EC 5.4.99.-) (Coiled-coil domain-containing protein 139) (tRNA pseudouridine 55 synthase) (Psi55 synthase) (tRNA pseudouridylate synthase) (tRNA-uridine isomerase) PUS10 CCDC139 DOBI Homo sapiens (Human) TR34076_c0_g1_i2 A1RX33 PUS10_THEPD 1.00E-38 GO:0009982; GO:0000049; GO:0031119 pseudouridine synthase activity; tRNA binding; tRNA pseudouridine synthesis IPR020103; IPR005912; IPR004114; tRNA pseudouridine synthase Pus10 (EC 5.4.99.-) (tRNA pseudouridine 54/55 synthase) (Psi54/55 synthase) pus10 Tpen_0354 Thermofilum pendens (strain Hrk 5) TR34077_c0_g1_i1 O60683 PEX10_HUMAN 1.00E-21 GO:0005779; GO:0005777; GO:0016558; GO:0008270 integral to peroxisomal membrane; peroxisome; protein import into peroxisome matrix; zinc ion binding IPR025654; IPR006845; IPR001841; IPR013083; IPR017907; Peroxisome biogenesis factor 10 (Peroxin-10) (Peroxisomal biogenesis factor 10) (Peroxisome assembly protein 10) (RING finger protein 69) PEX10 RNF69 Homo sapiens (Human) TR34077_c0_g1_i2 B1AUE5 PEX10_MOUSE 3.00E-22 GO:0005779; GO:0016558; GO:0008270 integral to peroxisomal membrane; protein import into peroxisome matrix; zinc ion binding IPR025654; IPR006845; IPR001841; IPR013083; IPR017907; Peroxisome biogenesis factor 10 (Peroxin-10) (Peroxisomal biogenesis factor 10) (Peroxisome assembly protein 10) Pex10 Mus musculus (Mouse) TR34077_c0_g2_i1 B1AUE5 PEX10_MOUSE 2.00E-43 GO:0005779; GO:0016558; GO:0008270 integral to peroxisomal membrane; protein import into peroxisome matrix; zinc ion binding IPR025654; IPR006845; IPR001841; IPR013083; IPR017907; Peroxisome biogenesis factor 10 (Peroxin-10) (Peroxisomal biogenesis factor 10) (Peroxisome assembly protein 10) Pex10 Mus musculus (Mouse) TR34077_c0_g2_i2 Q9SYU4 PEX10_ARATH 1.00E-22 GO:0010381; GO:0005829; GO:0009793; GO:0006635; GO:0005779; GO:0005777; GO:0009853; GO:0016558; GO:0006513; GO:0004842; GO:0008270 Q9SRQ3 attachment of peroxisome to chloroplast; cytosol; embryo development ending in seed dormancy; fatty acid beta-oxidation; integral to peroxisomal membrane; peroxisome; photorespiration; protein import into peroxisome matrix; protein monoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR025654; IPR006845; IPR001841; IPR013083; IPR017907; Peroxisome biogenesis factor 10 (PER10) (Peroxin-10) (Peroxisomal biogenesis factor 10) (AtPEX10) (AthPEX10) (Peroxisome assembly protein 10) (Pex10p) PEX10 At2g26350 T9J22.2 Arabidopsis thaliana (Mouse-ear cress) TR34078_c0_g1_i1 P36968 GPX4_PIG 2.00E-62 GO:0004602; GO:0005739; GO:0007275; GO:0047066; GO:0006979 glutathione peroxidase activity; mitochondrion; multicellular organismal development; phospholipid-hydroperoxide glutathione peroxidase activity; response to oxidative stress IPR000889; IPR012336; "Phospholipid hydroperoxide glutathione peroxidase, mitochondrial (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4)" GPX4 Sus scrofa (Pig) TR34078_c0_g1_i2 Q00277 GPX1_SCHMA 5.00E-62 GO:0004602; GO:0006979 glutathione peroxidase activity; response to oxidative stress IPR000889; IPR012336; Glutathione peroxidase (GPX) (EC 1.11.1.9) GPX1 Schistosoma mansoni (Blood fluke) TR34078_c0_g1_i4 O23968 GPX4_HELAN 4.00E-52 GO:0005737; GO:0004602; GO:0047066; GO:0006979 cytoplasm; glutathione peroxidase activity; phospholipid-hydroperoxide glutathione peroxidase activity; response to oxidative stress IPR000889; IPR012336; Probable phospholipid hydroperoxide glutathione peroxidase (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 2) GPXHA-2 Helianthus annuus (Common sunflower) TR34080_c3_g1_i1 P52304 POLO_DROME 4.00E-59 GO:0005524; GO:0030954; GO:0005814; GO:0051297; GO:0000940; GO:0035050; GO:0005828; GO:0007060; GO:0030496; GO:0007067; GO:1990023; GO:0007052; GO:0007406; GO:0005635; GO:0048600; GO:0006909; GO:0007344; GO:0035046; GO:0008104; GO:0004674; GO:0035044; GO:0007058; GO:0000922 ATP binding; astral microtubule nucleation; centriole; centrosome organization; condensed chromosome outer kinetochore; embryonic heart tube development; kinetochore microtubule; male meiosis chromosome segregation; midbody; mitosis; mitotic spindle midzone; mitotic spindle organization; negative regulation of neuroblast proliferation; nuclear envelope; oocyte fate commitment; phagocytosis; pronuclear fusion; pronuclear migration; protein localization; protein serine/threonine kinase activity; sperm aster formation; spindle assembly involved in female meiosis II; spindle pole IPR011009; IPR000959; IPR000719; IPR002290; IPR008271; Serine/threonine-protein kinase polo (EC 2.7.11.21) polo CG12306 Drosophila melanogaster (Fruit fly) TR34080_c3_g1_i2 O00444 PLK4_HUMAN 8.00E-109 GO:0005524; GO:0000086; GO:0005814; GO:0007099; GO:0032154; GO:0005829; GO:0005730; GO:0018108; GO:0046601; GO:0004674; GO:0004713; GO:0060707 P31947 ATP binding; G2/M transition of mitotic cell cycle; centriole; centriole replication; cleavage furrow; cytosol; nucleolus; peptidyl-tyrosine phosphorylation; positive regulation of centriole replication; protein serine/threonine kinase activity; protein tyrosine kinase activity; trophoblast giant cell differentiation IPR011009; IPR000959; IPR000719; IPR017441; IPR002290; IPR008266; Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) PLK4 SAK STK18 Homo sapiens (Human) TR34083_c0_g1_i1 Q0DAE4 GRXC8_ORYSJ 5.00E-11 GO:0045454; GO:0005737; GO:0009055; GO:0015035 cell redox homeostasis; cytoplasm; electron carrier activity; protein disulfide oxidoreductase activity IPR011767; IPR002109; IPR011899; IPR014025; IPR012336; Glutaredoxin-C8 (Glutaredoxin-C4 homolog) GRXC8 Os06g0659500 LOC_Os06g44910 B1047G05.35 OSJNBa0051O02.7 Oryza sativa subsp. japonica (Rice) TR34084_c0_g1_i1 Q86X83 COMD2_HUMAN 3.00E-82 IPR017920; IPR009886; COMM domain-containing protein 2 COMMD2 HSPC042 My004 Homo sapiens (Human) TR34085_c1_g1_i1 A8WQH2 PXDN_CAEBR 9.00E-07 GO:0005576; GO:0020037; GO:0042744; GO:0046872; GO:0004601 extracellular region; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Peroxidasin homolog (EC 1.11.1.7) pxn-1 CBG01526 Caenorhabditis briggsae TR34085_c1_g1_i2 Q62718 NTRI_RAT 5.00E-06 GO:0031225; GO:0030424; GO:0007155; GO:0009986; GO:0021549; GO:0060076; GO:0005615; GO:0010977; GO:0070492; GO:0048471; GO:0005886; GO:0032355 anchored to membrane; axon; cell adhesion; cell surface; cerebellum development; excitatory synapse; extracellular space; negative regulation of neuron projection development; oligosaccharide binding; perinuclear region of cytoplasm; plasma membrane; response to estradiol stimulus IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Neurotrimin (GP65) Ntm Hnt Nt Rattus norvegicus (Rat) TR34085_c1_g1_i3 Q24372 LACH_DROME 5.00E-09 GO:0031225; GO:0061343; GO:0007156; GO:0035160; GO:0016331; GO:0005886; GO:0042803; GO:0035151; GO:0005918; GO:0019991 Q9VGH2 "anchored to membrane; cell adhesion involved in heart morphogenesis; homophilic cell adhesion; maintenance of epithelial integrity, open tracheal system; morphogenesis of embryonic epithelium; plasma membrane; protein homodimerization activity; regulation of tube size, open tracheal system; septate junction; septate junction assembly" IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Lachesin Lac CG12369 Drosophila melanogaster (Fruit fly) TR34086_c0_g2_i1 P97393 RHG05_MOUSE 4.00E-52 GO:0005525; GO:0005096; GO:0005737; GO:0016020; GO:0043547; GO:0030335; GO:0002053; GO:0008361; GO:0007264 GTP binding; GTPase activator activity; cytoplasm; membrane; positive regulation of GTPase activity; positive regulation of cell migration; positive regulation of mesenchymal cell proliferation; regulation of cell size; small GTPase mediated signal transduction IPR002713; IPR027417; IPR008936; IPR000198; IPR001806; Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) Arhgap5 Rhogap5 Mus musculus (Mouse) TR34086_c1_g2_i2 Q5RJ80 CAPR2_DANRE 3.00E-08 GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:2000055; GO:0090263; GO:0050775; GO:0061003; GO:0040008 RNA binding; cytoplasm; dorsal/ventral pattern formation; negative regulation of translation; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of dendrite morphogenesis; positive regulation of dendritic spine morphogenesis; regulation of growth IPR001073; IPR008983; Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR34086_c2_g1_i1 Q8BRH3 RHG19_MOUSE 2.00E-08 GO:0005096; GO:0005622; GO:0043547; GO:0007165 GTPase activator activity; intracellular; positive regulation of GTPase activity; signal transduction IPR008936; IPR000198; Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19) Arhgap19 Mus musculus (Mouse) TR34086_c2_g1_i2 Q9P227 RHG23_HUMAN 2.00E-22 GO:0005096; GO:0005829; GO:0005543; GO:0043547; GO:0051056; GO:0007264 GTPase activator activity; cytosol; phospholipid binding; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR001478; IPR011993; IPR001849; IPR008936; IPR000198; Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) ARHGAP23 KIAA1501 Homo sapiens (Human) TR34086_c2_g1_i5 Q13017 RHG05_HUMAN 2.00E-40 GO:0005525; GO:0003924; GO:0005100; GO:0007266; GO:0007155; GO:0005829; GO:0016020; GO:0030335; GO:0002053; GO:0008361 GTP binding; GTPase activity; Rho GTPase activator activity; Rho protein signal transduction; cell adhesion; cytosol; membrane; positive regulation of cell migration; positive regulation of mesenchymal cell proliferation; regulation of cell size IPR002713; IPR027417; IPR008936; IPR000198; IPR001806; Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) ARHGAP5 RHOGAP5 Homo sapiens (Human) TR34090_c0_g1_i1 P34183 SYH_CAEEL 2.00E-168 GO:0005524; GO:0007281; GO:0004821; GO:0006427; GO:0005739; GO:0002119 ATP binding; germ cell development; histidine-tRNA ligase activity; histidyl-tRNA aminoacylation; mitochondrion; nematode larval development IPR006195; IPR004154; IPR015807; IPR004516; Histidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS) hrs-1 syh-1 T11G6.1 Caenorhabditis elegans TR34090_c0_g1_i2 P70076 SYHC_TAKRU 0 GO:0005524; GO:0005737; GO:0004821; GO:0006427 ATP binding; cytoplasm; histidine-tRNA ligase activity; histidyl-tRNA aminoacylation IPR006195; IPR004154; IPR015807; IPR004516; "Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)" hars hiss Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR34090_c0_g1_i3 Q2KI84 SYHC_BOVIN 0 GO:0005524; GO:0005737; GO:0004821; GO:0006427 ATP binding; cytoplasm; histidine-tRNA ligase activity; histidyl-tRNA aminoacylation IPR006195; IPR004154; IPR015807; IPR004516; IPR009068; IPR000738; "Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)" HARS Bos taurus (Bovine) TR34090_c0_g1_i4 Q2KI84 SYHC_BOVIN 0 GO:0005524; GO:0005737; GO:0004821; GO:0006427 ATP binding; cytoplasm; histidine-tRNA ligase activity; histidyl-tRNA aminoacylation IPR006195; IPR004154; IPR015807; IPR004516; IPR009068; IPR000738; "Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)" HARS Bos taurus (Bovine) TR34091_c2_g2_i1 P54729 NUB1_MOUSE 4.00E-55 GO:0005634; GO:0032436; GO:0016567; GO:0034341; GO:0034612; GO:0006511 nucleus; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; response to interferon-gamma; response to tumor necrosis factor; ubiquitin-dependent protein catabolic process IPR009060; IPR015940; IPR000449; NEDD8 ultimate buster 1 (Negative regulator of ubiquitin-like proteins 1) (Protein BS4) Nub1 Nyren18 Mus musculus (Mouse) TR34093_c0_g1_i1 Q8NLY8 DNAJ2_CORGL 6.00E-12 GO:0005524; GO:0006260; GO:0005737; GO:0006457; GO:0009408; GO:0008270 ATP binding; DNA replication; cytoplasm; protein folding; response to heat; zinc ion binding IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; Chaperone protein DnaJ 2 dnaJ2 Cgl2798 cg3098 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) TR34096_c3_g1_i3 Q08822 ETFD_YEAST 4.00E-98 GO:0051539; GO:0004174; GO:0046872; GO:0005743; GO:0005739 P36156 "4 iron, 4 sulfur cluster binding; electron-transferring-flavoprotein dehydrogenase activity; metal ion binding; mitochondrial inner membrane; mitochondrion" IPR017896; IPR007859; IPR006076; "Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETF-QO) (ETF-ubiquinone oxidoreductase) (EC 1.5.5.1) (Changed intracellular redox state protein 2) (Electron-transferring-flavoprotein dehydrogenase) (ETF dehydrogenase)" CIR2 YOR356W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR34096_c3_g2_i1 Q11190 ETFD_CAEEL 5.00E-141 GO:0051539; GO:0004174; GO:0046872; GO:0005743; GO:0005739 "4 iron, 4 sulfur cluster binding; electron-transferring-flavoprotein dehydrogenase activity; metal ion binding; mitochondrial inner membrane; mitochondrion" IPR017896; IPR007859; "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETF-QO) (ETF-ubiquinone oxidoreductase) (EC 1.5.5.1) (Electron-transferring-flavoprotein dehydrogenase) (ETF dehydrogenase) (Lethal protein 721)" let-721 C05D11.12 Caenorhabditis elegans TR34096_c3_g2_i2 Q2KIG0 ETFD_BOVIN 2.00E-173 GO:0051539; GO:0009055; GO:0022900; GO:0004174; GO:0033539; GO:0031305; GO:0046872; GO:0006979; GO:0048039 "4 iron, 4 sulfur cluster binding; electron carrier activity; electron transport chain; electron-transferring-flavoprotein dehydrogenase activity; fatty acid beta-oxidation using acyl-CoA dehydrogenase; integral to mitochondrial inner membrane; metal ion binding; response to oxidative stress; ubiquinone binding" IPR017896; IPR007859; "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETF-QO) (ETF-ubiquinone oxidoreductase) (EC 1.5.5.1) (Electron-transferring-flavoprotein dehydrogenase) (ETF dehydrogenase)" ETFDH Bos taurus (Bovine) TR34097_c0_g1_i3 Q8BTI8 SRRM2_MOUSE 1.00E-46 GO:0015030; GO:0008380; GO:0071013; GO:0006397; GO:0016607 Cajal body; RNA splicing; catalytic step 2 spliceosome; mRNA processing; nuclear speck IPR013170; IPR024945; Serine/arginine repetitive matrix protein 2 Srrm2 Kiaa0324 Mus musculus (Mouse) TR34098_c0_g1_i2 Q2TGI8 ZDH22_RAT 6.00E-18 GO:0016021; GO:0072659; GO:0018345; GO:0016746; GO:0008270 "integral to membrane; protein localization to plasma membrane; protein palmitoylation; transferase activity, transferring acyl groups; zinc ion binding" IPR000731; IPR001594; Palmitoyltransferase ZDHHC22 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 22) (DHHC-22) (zDHHC22) Zdhhc22 Rattus norvegicus (Rat) TR34098_c0_g1_i3 Q2TGI5 ZDH24_RAT 2.00E-20 GO:0016021; GO:0016746; GO:0008270 "integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Probable palmitoyltransferase ZDHHC24 (EC 2.3.1.225) (Membrane-associated zinc finger protein DHHC25) (Zinc finger DHHC domain-containing protein 24) (DHHC-24) Zdhhc24 Rattus norvegicus (Rat) TR34100_c0_g2_i1 Q3T0Y3 ST1B1_BOVIN 6.00E-40 GO:0004062; GO:0005737; GO:0009812; GO:0008202; GO:0051923; GO:0042403; GO:0006805 aryl sulfotransferase activity; cytoplasm; flavonoid metabolic process; steroid metabolic process; sulfation; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) SULT1B1 Bos taurus (Bovine) TR34101_c0_g1_i1 Q10292 MEK1_SCHPO 2.00E-08 GO:0005524; GO:0005829; GO:0030998; GO:0007126; GO:0051598; GO:0004674; GO:0090006 ATP binding; cytosol; linear element; meiosis; meiotic recombination checkpoint; protein serine/threonine kinase activity; regulation of linear element assembly IPR020636; IPR000253; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR008984; Meiosis-specific serine/threonine-protein kinase mek1 (EC 2.7.11.1) mek1 SPAC14C4.03 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR34101_c0_g2_i2 Q5F361 TBCK_CHICK 4.00E-56 GO:0005097; GO:0032851; GO:0016772 "Rab GTPase activator activity; positive regulation of Rab GTPase activity; transferase activity, transferring phosphorus-containing groups" IPR011009; IPR000719; IPR000195; IPR001763; TBC domain-containing protein kinase-like protein TBCK RCJMB04_32m11 Gallus gallus (Chicken) TR34101_c0_g3_i1 Q28C33 TBC30_XENTR 5.00E-14 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; TBC1 domain family member 30 tbc1d30 TEgg107a03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34101_c0_g3_i2 Q5F361 TBCK_CHICK 0 GO:0005097; GO:0032851; GO:0016772 "Rab GTPase activator activity; positive regulation of Rab GTPase activity; transferase activity, transferring phosphorus-containing groups" IPR011009; IPR000719; IPR000195; IPR001763; TBC domain-containing protein kinase-like protein TBCK RCJMB04_32m11 Gallus gallus (Chicken) TR34104_c1_g1_i1 Q2TA11 CA158_BOVIN 3.00E-34 Uncharacterized protein C1orf158 homolog Bos taurus (Bovine) TR34105_c0_g1_i1 Q64612 PTPRV_RAT 8.00E-29 GO:0046849; GO:0016021; GO:0035335; GO:0004725 bone remodeling; integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase V (R-PTP-V) (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase) (Osteotesticular protein-tyrosine phosphatase) (OST-PTP) Ptprv Esp Rattus norvegicus (Rat) TR34105_c0_g1_i2 P54829 PTN5_HUMAN 5.00E-23 GO:0005789; GO:0016021; GO:0001784; GO:0004725 endoplasmic reticulum membrane; integral to membrane; phosphotyrosine binding; protein tyrosine phosphatase activity IPR000387; IPR016130; IPR008356; IPR000242; IPR016334; Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP) PTPN5 Homo sapiens (Human) TR34105_c0_g1_i3 Q9HD43 PTPRH_HUMAN 3.00E-29 GO:0006915; GO:0005887; GO:0005739; GO:0005634; GO:0005001 P10912 apoptotic process; integral to plasma membrane; mitochondrion; nucleus; transmembrane receptor protein tyrosine phosphatase activity IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H) PTPRH SAP1 Homo sapiens (Human) TR34105_c1_g1_i2 P28828 PTPRM_MOUSE 4.00E-50 GO:0045296; GO:0005913; GO:0007156; GO:0016021; GO:0030027; GO:0016525; GO:0010596; GO:0001937; GO:0048471; GO:0045909; GO:0042493; GO:0010842; GO:0031290; GO:0005001 cadherin binding; cell-cell adherens junction; homophilic cell adhesion; integral to membrane; lamellipodium; negative regulation of angiogenesis; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; perinuclear region of cytoplasm; positive regulation of vasodilation; response to drug; retina layer formation; retinal ganglion cell axon guidance; transmembrane receptor protein tyrosine phosphatase activity IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR013151; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Ptprm Kiaa4044 Mus musculus (Mouse) TR34105_c1_g1_i3 P23470 PTPRG_HUMAN 5.00E-64 GO:0005887; GO:0007169; GO:0005001 P35222 integral to plasma membrane; transmembrane receptor protein tyrosine kinase signaling pathway; transmembrane receptor protein tyrosine phosphatase activity IPR001148; IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48) PTPRG PTPG Homo sapiens (Human) TR34105_c1_g1_i4 B1AUH1 PTPRU_MOUSE 1.00E-39 GO:0060070; GO:0030154; GO:0005911; GO:0034109; GO:0016021; GO:0030336; GO:0008285; GO:0005886; GO:0034394; GO:0004725 canonical Wnt receptor signaling pathway; cell differentiation; cell-cell junction; homotypic cell-cell adhesion; integral to membrane; negative regulation of cell migration; negative regulation of cell proliferation; plasma membrane; protein localization to cell surface; protein tyrosine phosphatase activity IPR008985; IPR003961; IPR013783; IPR003599; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Ftp-1) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase-lamda) (PTP-lambda) (PTPlambda) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi) Ptpru Pcp2 Ptpf Mus musculus (Mouse) TR34105_c1_g1_i5 Q9HD43 PTPRH_HUMAN 1.00E-27 GO:0006915; GO:0005887; GO:0005739; GO:0005634; GO:0005001 P10912 apoptotic process; integral to plasma membrane; mitochondrion; nucleus; transmembrane receptor protein tyrosine phosphatase activity IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H) PTPRH SAP1 Homo sapiens (Human) TR34105_c1_g1_i6 P54637 PTP3_DICDI 6.00E-09 GO:0005737; GO:0007243; GO:0035335; GO:0016791; GO:0034504; GO:0004725; GO:0006970; GO:0042501 cytoplasm; intracellular protein kinase cascade; peptidyl-tyrosine dephosphorylation; phosphatase activity; protein localization to nucleus; protein tyrosine phosphatase activity; response to osmotic stress; serine phosphorylation of STAT protein IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase 3 (EC 3.1.3.48) (Protein-tyrosine-phosphate phosphohydrolase 3) ptpC ptp3 DDB_G0282145 Dictyostelium discoideum (Slime mold) TR34106_c0_g2_i1 Q9VK89 TRM1_DROME 1.00E-153 GO:0004809; GO:0000049 tRNA (guanine-N2-)-methyltransferase activity; tRNA binding IPR002905; "Probable tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase)" CG6388 Drosophila melanogaster (Fruit fly) TR34106_c0_g2_i2 Q3TX08 TRM1_MOUSE 1.00E-160 GO:0046872; GO:0004809; GO:0000049 metal ion binding; tRNA (guanine-N2-)-methyltransferase activity; tRNA binding IPR002905; IPR000571; "tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase)" Trmt1 D8Ertd812e Mus musculus (Mouse) TR34109_c0_g1_i6 Q8JZL1 I17RD_MOUSE 7.00E-06 GO:0000139; GO:0016021; GO:0046872; GO:0005886 Golgi membrane; integral to membrane; metal ion binding; plasma membrane IPR013568; IPR007087; Interleukin-17 receptor D (IL-17 receptor D) (IL-17RD) (Interleukin-17 receptor-like protein) (Sef homolog) (mSef) Il17rd Il17rlm Sef Mus musculus (Mouse) TR34111_c0_g2_i2 Q5RF32 BHMT2_PONAB 1.00E-46 GO:0047150; GO:0005737; GO:0008898; GO:0009086; GO:0008270 betaine-homocysteine S-methyltransferase activity; cytoplasm; homocysteine S-methyltransferase activity; methionine biosynthetic process; zinc ion binding IPR017226; IPR003726; Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2) BHMT2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34113_c3_g1_i2 P59889 S39A1_DANRE 9.00E-37 GO:0016021; GO:0005886; GO:0008270; GO:0005385 integral to membrane; plasma membrane; zinc ion binding; zinc ion transmembrane transporter activity IPR003689; Zinc transporter ZIP1 (DrZIP1) (Solute carrier family 39 member 1) (Zrt- and Irt-like protein 1) (ZIP-1) slc39a1 zip1 sb:cb629 zgc:111852 Danio rerio (Zebrafish) (Brachydanio rerio) TR34115_c3_g1_i3 Q9QXV3 ING1_MOUSE 1.00E-12 GO:0007049; GO:0005634; GO:0045893; GO:0006606; GO:0010941; GO:0008270 "cell cycle; nucleus; positive regulation of transcription, DNA-dependent; protein import into nucleus; regulation of cell death; zinc ion binding" IPR024610; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Inhibitor of growth protein 1 Ing1 Mus musculus (Mouse) TR34116_c0_g1_i1 Q7M6Z4 KIF27_MOUSE 5.00E-14 GO:0005524; GO:0005929; GO:0042384; GO:0005737; GO:0003351; GO:0005871; GO:0005874; GO:0003777; GO:0021591 ATP binding; cilium; cilium assembly; cytoplasm; epithelial cilium movement; kinesin complex; microtubule; microtubule motor activity; ventricular system development IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF27 Kif27 Mus musculus (Mouse) TR34116_c10_g1_i1 Q54WR8 GNA1_DICDI 7.00E-31 GO:0006048; GO:0004343 UDP-N-acetylglucosamine biosynthetic process; glucosamine 6-phosphate N-acetyltransferase activity IPR016181; IPR000182; Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2. Glucosamine 6-phosphate N-acetyltransferase 1 (GNPNAT1) (EC 2.3.1.4) gna1 DDB_G0279475 Dictyostelium discoideum (Slime mold) TR34116_c10_g1_i2 Q9VAI0 GNA1_DROME 5.00E-56 GO:0006048; GO:0004343 UDP-N-acetylglucosamine biosynthetic process; glucosamine 6-phosphate N-acetyltransferase activity IPR016181; IPR000182; Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2. Probable glucosamine 6-phosphate N-acetyltransferase (EC 2.3.1.4) (Phosphoglucosamine acetylase) (Phosphoglucosamine transacetylase) CG1969 Drosophila melanogaster (Fruit fly) TR34116_c4_g1_i1 Q2M1P5 KIF7_HUMAN 7.00E-24 GO:0005524; GO:0005929; GO:0005871; GO:0003777; GO:0007018; GO:0045879; GO:0045880 ATP binding; cilium; kinesin complex; microtubule motor activity; microtubule-based movement; negative regulation of smoothened signaling pathway; positive regulation of smoothened signaling pathway IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF7 KIF7 UNQ340/PRO539 Homo sapiens (Human) TR34117_c2_g1_i1 P10533 RMIL_AVII1 2.00E-170 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR001245; IPR008271; Serine/threonine-protein kinase-transforming protein Rmil (EC 2.7.11.1) V-RMIL Avian retrovirus IC10 TR34117_c2_g1_i2 O19004 ARAF_PIG 3.00E-162 GO:0005524; GO:0035556; GO:0046872; GO:0005739; GO:0043066; GO:0033138; GO:0004674; GO:0005057; GO:0032006; GO:0032434 ATP binding; intracellular signal transduction; metal ion binding; mitochondrion; negative regulation of apoptotic process; positive regulation of peptidyl-serine phosphorylation; protein serine/threonine kinase activity; receptor signaling protein activity; regulation of TOR signaling cascade; regulation of proteasomal ubiquitin-dependent protein catabolic process IPR020454; IPR011009; IPR002219; IPR000719; IPR017441; IPR003116; IPR001245; IPR008271; Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) ARAF ARAF1 Sus scrofa (Pig) TR34117_c2_g1_i3 P15056 BRAF_HUMAN 0 GO:0005524; GO:0000186; GO:0005509; GO:0071277; GO:0005829; GO:0008543; GO:0043066; GO:0048011; GO:0005634; GO:0009887; GO:0005886; GO:0070374; GO:0010628; GO:0033138; GO:0004674; GO:0005057; GO:0070849; GO:0007264; GO:0007268 Itself; P08238; Q61097; Q13233; P04049; Q99N57; Q8CGE9; Q15349; Q13114; P31946; P63104 ATP binding; activation of MAPKK activity; calcium ion binding; cellular response to calcium ion; cytosol; fibroblast growth factor receptor signaling pathway; negative regulation of apoptotic process; neurotrophin TRK receptor signaling pathway; nucleus; organ morphogenesis; plasma membrane; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; protein serine/threonine kinase activity; receptor signaling protein activity; response to epidermal growth factor stimulus; small GTPase mediated signal transduction; synaptic transmission IPR020454; IPR011009; IPR002219; IPR000719; IPR017441; IPR003116; IPR001245; IPR008271; Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) BRAF BRAF1 RAFB1 Homo sapiens (Human) TR34118_c1_g1_i1 Q9BXW7 CECR5_HUMAN 4.00E-129 GO:0005739 mitochondrion IPR023214; IPR006357; IPR006353; Cat eye syndrome critical region protein 5 CECR5 Homo sapiens (Human) TR34118_c1_g1_i2 Q91WM2 CECR5_MOUSE 7.00E-127 GO:0005739 mitochondrion IPR023214; IPR006357; IPR006353; Cat eye syndrome critical region protein 5 homolog Cecr5 Mus musculus (Mouse) TR34118_c1_g1_i5 Q9BXW7 CECR5_HUMAN 2.00E-91 GO:0005739 mitochondrion IPR023214; IPR006357; IPR006353; Cat eye syndrome critical region protein 5 CECR5 Homo sapiens (Human) TR34118_c2_g1_i1 E9Q555 RN213_MOUSE 3.00E-13 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) Rnf213 Mus musculus (Mouse) TR34121_c2_g1_i1 A7RRJ0 FEN1_NEMVE 3.00E-175 GO:0003677; GO:0006281; GO:0006260; GO:0004519; GO:0004527; GO:0046872; GO:0005739; GO:0090305; GO:0005730; GO:0005654 DNA binding; DNA repair; DNA replication; endonuclease activity; exonuclease activity; metal ion binding; mitochondrion; nucleic acid phosphodiester bond hydrolysis; nucleolus; nucleoplasm IPR020045; IPR023426; IPR008918; IPR006086; IPR006084; IPR019974; IPR006085; Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (Flap structure-specific endonuclease 1) FEN1 v1g201054 Nematostella vectensis (Starlet sea anemone) TR34121_c2_g1_i2 B1H158 FEN1_XENTR 9.00E-169 GO:0003677; GO:0006281; GO:0006260; GO:0004519; GO:0004527; GO:0046872; GO:0005739; GO:0090305; GO:0005730; GO:0005654 DNA binding; DNA repair; DNA replication; endonuclease activity; exonuclease activity; metal ion binding; mitochondrion; nucleic acid phosphodiester bond hydrolysis; nucleolus; nucleoplasm IPR020045; IPR023426; IPR008918; IPR006086; IPR006084; IPR019974; IPR006085; Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (Flap structure-specific endonuclease 1) fen1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34122_c0_g1_i1 Q81LW0 SODM1_BACAN 5.00E-62 GO:0046872; GO:0004784; GO:0006801 metal ion binding; superoxide dismutase activity; superoxide metabolic process IPR001189; IPR019833; IPR019832; IPR019831; Superoxide dismutase [Mn] 1 (EC 1.15.1.1) sodA1 sodA-1 BA_4499 GBAA_4499 BAS4177 Bacillus anthracis TR34122_c0_g1_i3 Q9F326 SODM_STACA 5.00E-62 GO:0046872; GO:0006950; GO:0004784; GO:0006801 metal ion binding; response to stress; superoxide dismutase activity; superoxide metabolic process IPR001189; IPR019833; IPR019832; IPR019831; Superoxide dismutase [Mn/Fe] (EC 1.15.1.1) sodA sod Staphylococcus carnosus TR34124_c7_g1_i1 Q55G87 CANB1_DICDI 1.00E-14 GO:0005955; GO:0005509; GO:0031287; GO:0006470; GO:0043157 calcineurin complex; calcium ion binding; positive regulation of sorocarp stalk cell differentiation; protein dephosphorylation; response to cation stress IPR011992; IPR018247; IPR002048; IPR001125; Calcineurin subunit B type 1 (Calcineurin regulatory subunit 1) (Protein phosphatase 2B regulatory subunit 1) cnbA DDB_G0267446 Dictyostelium discoideum (Slime mold) TR34124_c7_g1_i2 P42322 CANB1_NAEGR 9.00E-15 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calcineurin subunit B (Calcineurin regulatory subunit) (Protein phosphatase 2B regulatory subunit) CNB1 Naegleria gruberi (Amoeba) TR34124_c8_g1_i1 Q9Y6K5 OAS3_HUMAN 3.00E-21 GO:0001730; GO:0005524; GO:0005829; GO:0051607; GO:0003725; GO:0060333; GO:0043231; GO:0046872; GO:0045071; GO:0006139; GO:0005634; GO:0060700; GO:0060337 Q7L2E3; P56537; Q8IY81; Q12894; Q7Z434 2'-5'-oligoadenylate synthetase activity; ATP binding; cytosol; defense response to virus; double-stranded RNA binding; interferon-gamma-mediated signaling pathway; intracellular membrane-bounded organelle; metal ion binding; negative regulation of viral genome replication; nucleobase-containing compound metabolic process; nucleus; regulation of ribonuclease activity; type I interferon-mediated signaling pathway IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (p100 OAS) (p100OAS) OAS3 P/OKcl.4 Homo sapiens (Human) TR34125_c5_g3_i2 Q0P3X7 CV039_DANRE 2.00E-15 IPR021475; UPF0545 protein C22orf39 homolog Danio rerio (Zebrafish) (Brachydanio rerio) TR34127_c0_g1_i1 O93327 H2AY_CHICK 9.00E-125 GO:0003677; GO:0016568; GO:0000786; GO:0006334; GO:0005634 DNA binding; chromatin modification; nucleosome; nucleosome assembly; nucleus IPR021171; IPR009072; IPR007125; IPR002119; IPR002589; Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (H2A.y) (H2A/y) H2AFY Gallus gallus (Chicken) TR34127_c0_g1_i2 P16865 H2A3_VOLCA 3.00E-44 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR002119; Histone H2A-III Volvox carteri (Green alga) TR34127_c0_g1_i3 Q8RB30 Y995_THETN 6.00E-32 IPR002589; Macro domain-containing protein TTE0995 TTE0995 Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis) TR34129_c0_g1_i1 Q8RYJ9 CML23_ORYSJ 2.00E-13 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Putative calcium-binding protein CML23 (Calmodulin-like protein 23) CML23 Os01g0955400 LOC_Os01g72540 B1139B11.18 OsJ_004699 Oryza sativa subsp. japonica (Rice) TR34129_c0_g1_i2 P19123 TNNC1_MOUSE 1.00E-40 GO:0051015; GO:0005509; GO:0060048; GO:0043462; GO:0032972; GO:0005861; GO:0055010 actin filament binding; calcium ion binding; cardiac muscle contraction; regulation of ATPase activity; regulation of muscle filament sliding speed; troponin complex; ventricular cardiac muscle tissue morphogenesis IPR011992; IPR018247; IPR002048; IPR001125; "Troponin C, slow skeletal and cardiac muscles (TN-C)" Tnnc1 Tncc Mus musculus (Mouse) TR34129_c0_g1_i3 Q9GRJ1 CALM_LUMRU 8.00E-87 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Lumbricus rubellus (Humus earthworm) TR34132_c3_g1_i1 Q09415 SET14_CAEEL 7.00E-06 GO:0003677; GO:0046872; GO:0005634 DNA binding; metal ion binding; nucleus IPR002893; SET domain-containing protein 14 set-14 R06F6.4 Caenorhabditis elegans TR34132_c4_g1_i2 Q7TSL3 FBX11_RAT 2.00E-07 GO:0005694; GO:0005634; GO:0004842; GO:0008270 chromosome; nucleus; ubiquitin-protein ligase activity; zinc ion binding IPR006633; IPR001810; IPR007742; IPR022441; IPR006626; IPR012334; IPR011050; IPR003126; Protein modification; protein ubiquitination. F-box only protein 11 Fbxo11 Rattus norvegicus (Rat) TR34136_c0_g2_i1 Q6IMH0 TEPP_MOUSE 1.00E-32 "Testis, prostate and placenta-expressed protein" Tepp Mus musculus (Mouse) TR34139_c0_g2_i1 P09383 HPRT_SCHMA 9.00E-41 GO:0032264; GO:0005737; GO:0052657; GO:0004422; GO:0046872; GO:0000166; GO:0006166 IMP salvage; cytoplasm; guanine phosphoribosyltransferase activity; hypoxanthine phosphoribosyltransferase activity; metal ion binding; nucleotide binding; purine ribonucleoside salvage IPR005904; IPR000836; Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1. Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) HGPRT Schistosoma mansoni (Blood fluke) TR34139_c0_g2_i2 P47959 HPRT_MERUN 2.00E-76 GO:0046038; GO:0046040; GO:0032264; GO:0007610; GO:0005737; GO:0052657; GO:0006178; GO:0004422; GO:0043103; GO:0000287; GO:0000166; GO:0045964; GO:0042803; GO:0051289; GO:0006164; GO:0006166 GMP catabolic process; IMP metabolic process; IMP salvage; behavior; cytoplasm; guanine phosphoribosyltransferase activity; guanine salvage; hypoxanthine phosphoribosyltransferase activity; hypoxanthine salvage; magnesium ion binding; nucleotide binding; positive regulation of dopamine metabolic process; protein homodimerization activity; protein homotetramerization; purine nucleotide biosynthetic process; purine ribonucleoside salvage IPR005904; IPR000836; Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1. Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) HPRT1 HPRT Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) TR34140_c0_g4_i1 Q9JKP8 CHRC1_MOUSE 2.00E-24 GO:0003887; GO:0005634; GO:0043565 DNA-directed DNA polymerase activity; nucleus; sequence-specific DNA binding IPR003958; IPR009072; Chromatin accessibility complex protein 1 (CHRAC-1) (DNA polymerase epsilon subunit p15) (NF-YC-like protein) (YC-like protein 1) (YCL1) Chrac1 Mus musculus (Mouse) TR34140_c0_g4_i2 Q9SMP0 NFYC1_ARATH 1.00E-09 GO:0016602; GO:0045893; GO:0043565; GO:0003700; GO:0006351 Q39057 "CCAAT-binding factor complex; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR003958; IPR009072; IPR027170; Nuclear transcription factor Y subunit C-1 (AtNF-YC-1) (Transcriptional activator HAP5A) NFYC1 HAP5A At3g48590 T8P19.100 Arabidopsis thaliana (Mouse-ear cress) TR34142_c0_g1_i1 Q40784 AAPC_CENCI 7.00E-55 GO:0030246; GO:0005975; GO:0047938 carbohydrate binding; carbohydrate metabolic process; glucose-6-phosphate 1-epimerase activity IPR008183; IPR025532; IPR011013; IPR014718; Putative glucose-6-phosphate 1-epimerase (EC 5.1.3.15) (Putative D-hexose-6-phosphate mutarotase) (Putative apospory-associated protein C) Cenchrus ciliaris (Buffelgrass) (Pennisetum ciliare) TR34145_c0_g1_i1 Q8WVM7 STAG1_HUMAN 0 GO:0051301; GO:0030054; GO:0000785; GO:0007059; GO:0000775; GO:0005829; GO:0007067; GO:0000278; GO:0005654 Q29RF7; Q9NTI5; Q9UQE7; P54274 "cell division; cell junction; chromatin; chromosome segregation; chromosome, centromeric region; cytosol; mitosis; mitotic cell cycle; nucleoplasm" IPR016024; IPR020839; IPR013721; Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) STAG1 SA1 Homo sapiens (Human) TR34145_c1_g2_i5 Q8WVM7 STAG1_HUMAN 1.00E-134 GO:0051301; GO:0030054; GO:0000785; GO:0007059; GO:0000775; GO:0005829; GO:0007067; GO:0000278; GO:0005654 Q29RF7; Q9NTI5; Q9UQE7; P54274 "cell division; cell junction; chromatin; chromosome segregation; chromosome, centromeric region; cytosol; mitosis; mitotic cell cycle; nucleoplasm" IPR016024; IPR020839; IPR013721; Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) STAG1 SA1 Homo sapiens (Human) TR34147_c1_g1_i1 P98066 TSG6_HUMAN 3.00E-17 GO:0007155; GO:0007267; GO:0005540; GO:0006954; GO:0007165 cell adhesion; cell-cell signaling; hyaluronic acid binding; inflammatory response; signal transduction IPR016186; IPR016187; IPR000859; IPR000538; Tumor necrosis factor-inducible gene 6 protein (Hyaluronate-binding protein) (TNF-stimulated gene 6 protein) (TSG-6) (Tumor necrosis factor alpha-induced protein 6) (TNF alpha-induced protein 6) TNFAIP6 TSG6 Homo sapiens (Human) TR34147_c1_g1_i2 O35276 NRP2_RAT 3.00E-09 GO:0001525; GO:0030424; GO:0007411; GO:0007155; GO:0007507; GO:0008201; GO:0016021; GO:0046872; GO:0050919; GO:0001755; GO:0017154; GO:0005021 angiogenesis; axon; axon guidance; cell adhesion; heart development; heparin binding; integral to membrane; metal ion binding; negative chemotaxis; neural crest cell migration; semaphorin receptor activity; vascular endothelial growth factor-activated receptor activity IPR000421; IPR008985; IPR000859; IPR008979; IPR000998; IPR014648; IPR022579; Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) Nrp2 Rattus norvegicus (Rat) TR34147_c2_g1_i1 P42674 BP10_PARLI 2.00E-28 GO:0005938; GO:0005615; GO:0004222; GO:0048471; GO:0006508; GO:0008270 cell cortex; extracellular space; metalloendopeptidase activity; perinuclear region of cytoplasm; proteolysis; zinc ion binding IPR000859; IPR000742; IPR013032; IPR024079; IPR001506; IPR006026; IPR017369; Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) TR34147_c2_g2_i1 Q7LZ71 IXA_PROFL 3.00E-06 GO:0030246; GO:0005576; GO:0046872 carbohydrate binding; extracellular region; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; Snaclec coagulation factor IX-binding protein subunit A (IX-bp subunit A) Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis) TR34147_c2_g2_i2 P81509 CHBBB_CROHD 3.00E-06 GO:0044477; GO:0005576 envenomation resulting in negative regulation of platelet aggregation in other organism; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Snaclec CHH-B subunit beta Crotalus horridus (Timber rattlesnake) TR34149_c3_g1_i1 Q5RDQ2 MPP5_PONAB 0 GO:0012505; GO:0005886; GO:0005923 endomembrane system; plasma membrane; tight junction IPR008145; IPR008144; IPR020590; IPR004172; IPR014775; IPR015145; IPR027417; IPR001478; IPR011511; IPR001452; MAGUK p55 subfamily member 5 MPP5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34149_c3_g1_i2 Q5RDQ2 MPP5_PONAB 1.00E-118 GO:0012505; GO:0005886; GO:0005923 endomembrane system; plasma membrane; tight junction IPR008145; IPR008144; IPR020590; IPR004172; IPR014775; IPR015145; IPR027417; IPR001478; IPR011511; IPR001452; MAGUK p55 subfamily member 5 MPP5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34150_c0_g2_i2 Q1RMG8 RPAC2_BOVIN 8.00E-35 GO:0003677; GO:0005736; GO:0005666; GO:0003899; GO:0006360; GO:0006383 DNA binding; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase activity; transcription from RNA polymerase I promoter; transcription from RNA polymerase III promoter IPR009025; IPR008193; DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (DNA-directed RNA polymerase I subunit D) POLR1D Bos taurus (Bovine) TR34150_c0_g2_i3 Q09177 RPAC2_SCHPO 8.00E-29 GO:0003677; GO:0005736; GO:0005666; GO:0003899; GO:0006360; GO:0006383 DNA binding; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase activity; transcription from RNA polymerase I promoter; transcription from RNA polymerase III promoter IPR009025; IPR008193; DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerases I and III 14 kDa polypeptide) rpc19 rpa17 SPAC1687.01 SPAPYUL23.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR34150_c0_g2_i4 Q9VIZ0 RPAC2_DROME 1.00E-28 GO:0003677; GO:0005736; GO:0005666; GO:0003899; GO:0005875; GO:0006360; GO:0006383 DNA binding; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase activity; microtubule associated complex; transcription from RNA polymerase I promoter; transcription from RNA polymerase III promoter IPR009025; IPR008193; Probable DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerase I subunit D) l(2)37Cg CG10685 Drosophila melanogaster (Fruit fly) TR34150_c0_g2_i7 Q60SM4 RPB11_CAEBR 1.00E-11 GO:0003677; GO:0003899; GO:0005634; GO:0006351 "DNA binding; DNA-directed RNA polymerase activity; nucleus; transcription, DNA-dependent" IPR009025; IPR008193; Probable DNA-directed RNA polymerase II subunit RPB11 (RNA polymerase II subunit B11) (DNA-directed RNA polymerase II subunit J) rpb-11 CBG20834 Caenorhabditis briggsae TR34150_c0_g2_i8 Q5XK67 RPAC2_XENLA 7.00E-37 GO:0003677; GO:0003899; GO:0005634; GO:0006351 "DNA binding; DNA-directed RNA polymerase activity; nucleus; transcription, DNA-dependent" IPR009025; IPR008193; DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerase I subunit D) polr1d Xenopus laevis (African clawed frog) TR34151_c1_g1_i1 O01367 HOW_DROME 7.00E-83 GO:0007475; GO:0008366; GO:0007155; GO:0005737; GO:0030718; GO:0008347; GO:0003730; GO:0008078; GO:0016203; GO:0007521; GO:0005634; GO:0007438; GO:0000381; GO:0008016; GO:0045214; GO:0007525; GO:0007284 "apposition of dorsal and ventral imaginal disc-derived wing surfaces; axon ensheathment; cell adhesion; cytoplasm; germ-line stem cell maintenance; glial cell migration; mRNA 3'-UTR binding; mesodermal cell migration; muscle attachment; muscle cell fate determination; nucleus; oenocyte development; regulation of alternative mRNA splicing, via spliceosome; regulation of heart contraction; sarcomere organization; somatic muscle development; spermatogonial cell division" IPR004087; IPR004088; Protein held out wings (KH domain protein KH93F) (Protein muscle-specific) (Protein struthio) (Protein wings held out) (Putative RNA-binding protein) (Quaking-related 93F) how KH93F qkr93F stru who CG10293 Drosophila melanogaster (Fruit fly) TR34151_c1_g1_i11 Q75GR5 SPIN1_ORYSJ 2.00E-27 GO:0003677; GO:0003723; GO:0009908; GO:0048579; GO:0048577; GO:0005634 "DNA binding; RNA binding; flower development; negative regulation of long-day photoperiodism, flowering; negative regulation of short-day photoperiodism, flowering; nucleus" IPR004087; IPR004088; KH domain-containing protein SPIN1 (SPL11-interacting protein 1) SPIN1 Os03g0815700 LOC_Os03g60110 OsJ_13097 OSJNBb0042K11.3 Oryza sativa subsp. japonica (Rice) TR34151_c1_g1_i13 O01367 HOW_DROME 4.00E-82 GO:0007475; GO:0008366; GO:0007155; GO:0005737; GO:0030718; GO:0008347; GO:0003730; GO:0008078; GO:0016203; GO:0007521; GO:0005634; GO:0007438; GO:0000381; GO:0008016; GO:0045214; GO:0007525; GO:0007284 "apposition of dorsal and ventral imaginal disc-derived wing surfaces; axon ensheathment; cell adhesion; cytoplasm; germ-line stem cell maintenance; glial cell migration; mRNA 3'-UTR binding; mesodermal cell migration; muscle attachment; muscle cell fate determination; nucleus; oenocyte development; regulation of alternative mRNA splicing, via spliceosome; regulation of heart contraction; sarcomere organization; somatic muscle development; spermatogonial cell division" IPR004087; IPR004088; Protein held out wings (KH domain protein KH93F) (Protein muscle-specific) (Protein struthio) (Protein wings held out) (Putative RNA-binding protein) (Quaking-related 93F) how KH93F qkr93F stru who CG10293 Drosophila melanogaster (Fruit fly) TR34151_c1_g1_i15 Q32NN2 QKIA_XENLA 1.00E-75 GO:0003723; GO:0008380; GO:0030154; GO:0005737; GO:0006397; GO:0051028; GO:0007275; GO:0005634; GO:0006417 RNA binding; RNA splicing; cell differentiation; cytoplasm; mRNA processing; mRNA transport; multicellular organismal development; nucleus; regulation of translation IPR004087; IPR004088; Protein quaking-A (Xqua) qki-a Xenopus laevis (African clawed frog) TR34151_c1_g1_i2 Q32NN2 QKIA_XENLA 2.00E-83 GO:0003723; GO:0008380; GO:0030154; GO:0005737; GO:0006397; GO:0051028; GO:0007275; GO:0005634; GO:0006417 RNA binding; RNA splicing; cell differentiation; cytoplasm; mRNA processing; mRNA transport; multicellular organismal development; nucleus; regulation of translation IPR004087; IPR004088; Protein quaking-A (Xqua) qki-a Xenopus laevis (African clawed frog) TR34151_c1_g1_i4 O01367 HOW_DROME 5.00E-87 GO:0007475; GO:0008366; GO:0007155; GO:0005737; GO:0030718; GO:0008347; GO:0003730; GO:0008078; GO:0016203; GO:0007521; GO:0005634; GO:0007438; GO:0000381; GO:0008016; GO:0045214; GO:0007525; GO:0007284 "apposition of dorsal and ventral imaginal disc-derived wing surfaces; axon ensheathment; cell adhesion; cytoplasm; germ-line stem cell maintenance; glial cell migration; mRNA 3'-UTR binding; mesodermal cell migration; muscle attachment; muscle cell fate determination; nucleus; oenocyte development; regulation of alternative mRNA splicing, via spliceosome; regulation of heart contraction; sarcomere organization; somatic muscle development; spermatogonial cell division" IPR004087; IPR004088; Protein held out wings (KH domain protein KH93F) (Protein muscle-specific) (Protein struthio) (Protein wings held out) (Putative RNA-binding protein) (Quaking-related 93F) how KH93F qkr93F stru who CG10293 Drosophila melanogaster (Fruit fly) TR34151_c1_g1_i7 Q6P104 QKIB_DANRE 2.00E-79 GO:0003723; GO:0008380; GO:0030154; GO:0005737; GO:0006397; GO:0051028; GO:0007275; GO:0005634; GO:0006417 RNA binding; RNA splicing; cell differentiation; cytoplasm; mRNA processing; mRNA transport; multicellular organismal development; nucleus; regulation of translation IPR004087; IPR004088; Protein quaking-B (Quaking-related protein) qkib qkr zgc:65890 zgc:77340 Danio rerio (Zebrafish) (Brachydanio rerio) TR34151_c2_g1_i1 Q9C5S1 MKP1_ARATH 1.00E-11 GO:0017017; GO:0005829; GO:0006952; GO:0035335; GO:0004725; GO:0010224; GO:0010225; GO:0009651 MAP kinase tyrosine/serine/threonine phosphatase activity; cytosol; defense response; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; response to UV-B; response to UV-C; response to salt stress IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Protein-tyrosine-phosphatase MKP1 (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 1) (AtMKP1) MKP1 At3g55270 T26I12.150 Arabidopsis thaliana (Mouse-ear cress) TR34151_c2_g1_i2 Q9ZR37 DUS1_ARATH 2.00E-23 GO:0005737; GO:0005634; GO:0035335; GO:0004725; GO:0008138 cytoplasm; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR020417; IPR000340; IPR020422; IPR024950; IPR000387; Dual specificity protein phosphatase 1 (AtDsPTP1) (EC 3.1.3.16) (EC 3.1.3.48) DSPTP1 At3g23610 MDB19.10 Arabidopsis thaliana (Mouse-ear cress) TR34151_c3_g1_i1 Q17QM8 DUS14_BOVIN 2.00E-48 GO:0017017; GO:0035335; GO:0004725; GO:0008138 MAP kinase tyrosine/serine/threonine phosphatase activity; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR020417; IPR020420; IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Dual specificity protein phosphatase 14 (EC 3.1.3.16) (EC 3.1.3.48) DUSP14 Bos taurus (Bovine) TR34151_c3_g1_i3 Q9UII6 DUS13_HUMAN 7.00E-14 GO:0007126; GO:0035335; GO:0004725; GO:0008138; GO:0007283 meiosis; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; spermatogenesis IPR020417; IPR020405; IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Dual specificity protein phosphatase 13 isoform B (DUSP13B) (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase SKRP4) (Testis- and skeletal-muscle-specific DSP) DUSP13 DUSP13B TMDP Homo sapiens (Human) TR34151_c3_g1_i4 Q17QM8 DUS14_BOVIN 5.00E-51 GO:0017017; GO:0035335; GO:0004725; GO:0008138 MAP kinase tyrosine/serine/threonine phosphatase activity; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR020417; IPR020420; IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Dual specificity protein phosphatase 14 (EC 3.1.3.16) (EC 3.1.3.48) DUSP14 Bos taurus (Bovine) TR34151_c3_g1_i5 Q8K330 SSH3_MOUSE 4.00E-15 GO:0003677; GO:0003779; GO:0005737; GO:0005856; GO:0005634; GO:0035335; GO:0004725; GO:0008138; GO:0008064; GO:0050770; GO:0010591 DNA binding; actin binding; cytoplasm; cytoskeleton; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; regulation of actin polymerization or depolymerization; regulation of axonogenesis; regulation of lamellipodium assembly IPR014876; IPR000340; IPR020422; IPR024950; IPR009057; IPR000387; IPR016130; Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (mSSH-3L) Ssh3 Ssh3l Mus musculus (Mouse) TR34155_c0_g1_i1 Q76MT4 ESF1_RAT 8.00E-68 GO:0005730; GO:0005654; GO:0006355; GO:0006351 "nucleolus; nucleoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR012580; ESF1 homolog (ABT1-associated protein) Esf1 Abtap Rattus norvegicus (Rat) TR34156_c5_g1_i1 P08478 AMDA_XENLA 2.00E-20 GO:0005507; GO:0016021; GO:0006518; GO:0004598; GO:0004504; GO:0030658 copper ion binding; integral to membrane; peptide metabolic process; peptidylamidoglycolate lyase activity; peptidylglycine monooxygenase activity; transport vesicle membrane IPR011042; IPR014784; IPR020611; IPR014783; IPR000323; IPR001258; IPR013017; IPR000720; IPR008977; Peptidyl-glycine alpha-amidating monooxygenase A (PAM-A) (Peptide C-terminal alpha-amidating enzyme I) (AE-I) (Peptidyl-glycine alpha-amidating monooxygenase I) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase A (PHM-A) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase A (EC 4.3.2.5) (Peptidylamidoglycolate lyase-A) (PAL-A)] pam-a Xenopus laevis (African clawed frog) TR34156_c5_g1_i2 Q95XM2 PHM_CAEEL 2.00E-15 GO:0005507; GO:0005576; GO:0016020; GO:0006518; GO:0004504 copper ion binding; extracellular region; membrane; peptide metabolic process; peptidylglycine monooxygenase activity IPR014784; IPR014783; IPR000323; IPR000720; IPR008977; Probable peptidylglycine alpha-hydroxylating monooxygenase Y71G12B.4 (PHM) (EC 1.14.17.3) Y71G12B.4 Caenorhabditis elegans TR34156_c5_g1_i3 Q95XM2 PHM_CAEEL 2.00E-18 GO:0005507; GO:0005576; GO:0016020; GO:0006518; GO:0004504 copper ion binding; extracellular region; membrane; peptide metabolic process; peptidylglycine monooxygenase activity IPR014784; IPR014783; IPR000323; IPR000720; IPR008977; Probable peptidylglycine alpha-hydroxylating monooxygenase Y71G12B.4 (PHM) (EC 1.14.17.3) Y71G12B.4 Caenorhabditis elegans TR34157_c0_g1_i1 Q6PB70 ANO8_MOUSE 6.00E-73 GO:0016021; GO:0005622; GO:0005886 integral to membrane; intracellular; plasma membrane IPR007632; Anoctamin-8 (Transmembrane protein 16H) Ano8 Kiaa1623 Tmem16h Mus musculus (Mouse) TR34157_c0_g1_i3 Q9NW15 ANO10_HUMAN 0 GO:0008219; GO:0016021; GO:0005622; GO:0034220; GO:0005886 cell death; integral to membrane; intracellular; ion transmembrane transport; plasma membrane IPR007632; Anoctamin-10 (Transmembrane protein 16K) ANO10 TMEM16K Homo sapiens (Human) TR34159_c1_g1_i1 Q68D51 DEN2C_HUMAN 1.00E-07 GO:0017112 Rab guanyl-nucleotide exchange factor activity IPR005112; IPR001194; IPR005113; DENN domain-containing protein 2C DENND2C Homo sapiens (Human) TR34159_c1_g1_i2 Q3U1T9 DEN1B_MOUSE 3.00E-47 GO:0017112; GO:0030136; GO:0005829; GO:0015031 Rab guanyl-nucleotide exchange factor activity; clathrin-coated vesicle; cytosol; protein transport IPR005112; IPR001194; IPR005113; DENN domain-containing protein 1B (Connecdenn 2) Dennd1b Mus musculus (Mouse) TR34159_c6_g1_i1 P78524 ST5_HUMAN 2.00E-12 GO:0017112; GO:0070374 Rab guanyl-nucleotide exchange factor activity; positive regulation of ERK1 and ERK2 cascade IPR005112; IPR001194; IPR005113; Suppression of tumorigenicity 5 protein (DENN domain-containing protein 2B) (HeLa tumor suppression 1) ST5 DENND2B HTS1 Homo sapiens (Human) TR34161_c7_g1_i1 Q17LW0 MYO7A_AEDAE 1.00E-45 GO:0005524; GO:0030048; GO:0030898; GO:0048800; GO:0008407; GO:0005737; GO:0035317; GO:0003774; GO:0016459; GO:0032027; GO:0007605 ATP binding; actin filament-based movement; actin-dependent ATPase activity; antennal morphogenesis; chaeta morphogenesis; cytoplasm; imaginal disc-derived wing hair organization; motor activity; myosin complex; myosin light chain binding; sensory perception of sound IPR019749; IPR014352; IPR019748; IPR000299; IPR018979; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; IPR001452; Myosin-VIIa (Protein crinkled) ck AAEL001220 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR34162_c0_g2_i1 Q9P7V8 MPCP_SCHPO 5.00E-93 GO:0005315; GO:0016021; GO:0005743; GO:0031966; GO:0006839; GO:0035435 inorganic phosphate transmembrane transporter activity; integral to membrane; mitochondrial inner membrane; mitochondrial membrane; mitochondrial transport; phosphate ion transmembrane transport IPR018108; IPR023395; Probable mitochondrial phosphate carrier protein SPBC1703.13c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR34162_c0_g2_i2 Q8VEM8 MPCP_MOUSE 2.00E-173 GO:0016021; GO:0005743; GO:0015293 integral to membrane; mitochondrial inner membrane; symporter activity IPR018108; IPR023395; "Phosphate carrier protein, mitochondrial (Phosphate transport protein) (PTP) (Solute carrier family 25 member 3)" Slc25a3 Mus musculus (Mouse) TR34162_c0_g3_i1 O61703 MPCP_CHOFU 3.00E-19 GO:0016021; GO:0005743; GO:0006810 integral to membrane; mitochondrial inner membrane; transport IPR018108; IPR023395; "Phosphate carrier protein, mitochondrial (Phosphate transport protein) (PTP)" Choristoneura fumiferana (Spruce budworm moth) (Archips fumiferana) TR34163_c0_g2_i2 Q8K2G4 BBS7_MOUSE 0 GO:0034464; GO:0007420; GO:0005813; GO:0035085; GO:0036064; GO:0060170; GO:0001654; GO:0045444; GO:0007507; GO:0060173; GO:0005634; GO:0060021; GO:0008104; GO:0007224 BBSome; brain development; centrosome; cilium axoneme; cilium basal body; cilium membrane; eye development; fat cell differentiation; heart development; limb development; nucleus; palate development; protein localization; smoothened signaling pathway IPR016575; IPR015943; IPR017986; Bardet-Biedl syndrome 7 protein homolog (BBS2-like protein 1) Bbs7 Bbs2l1 Mus musculus (Mouse) TR34164_c0_g1_i1 Q8BWF2 GIMA5_MOUSE 3.00E-28 GO:0005525; GO:0016021; GO:0005764; GO:0005741 GTP binding; integral to membrane; lysosome; mitochondrial outer membrane IPR006703; IPR027417; GTPase IMAP family member 5 (Immunity-associated nucleotide 4-like 1 protein) (Immunity-associated protein 3) Gimap5 Ian4l1 Imap3 Mus musculus (Mouse) TR34164_c0_g1_i2 Q9NUV9 GIMA4_HUMAN 2.00E-35 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR34165_c0_g1_i1 Q9R226 KHDR3_MOUSE 4.00E-52 GO:0003723; GO:0005634; GO:0006355; GO:0006351 "RNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR004087; "KH domain-containing, RNA-binding, signal transduction-associated protein 3 (RNA-binding protein Etoile) (Sam68-like mammalian protein 2) (SLM-2)" Khdrbs3 Salp Slm2 Mus musculus (Mouse) TR34166_c0_g1_i1 Q2NL14 KANL2_BOVIN 3.00E-94 GO:0043984; GO:0043981; GO:0043982; GO:0046972; GO:0043995; GO:0043996; GO:0000123 histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase activity (H4-K16 specific); histone acetyltransferase activity (H4-K5 specific); histone acetyltransferase activity (H4-K8 specific); histone acetyltransferase complex IPR026316; IPR025927; KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog) KANSL2 NSL2 Bos taurus (Bovine) TR34166_c0_g2_i1 Q66JY2 IN80D_MOUSE 1.00E-15 GO:0006310; GO:0006281; GO:0005634; GO:0006355; GO:0006351 "DNA recombination; DNA repair; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025927; INO80 complex subunit D Ino80d Mus musculus (Mouse) TR34168_c0_g1_i1 O08863 BIRC3_MOUSE 2.00E-17 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 P39429 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Inhibitor of apoptosis protein 1) (IAP-1) (mIAP-1) (mIAP1) Birc3 Birc2 Iap1 Mus musculus (Mouse) TR34170_c3_g2_i4 O95999 BCL10_HUMAN 2.00E-15 GO:0032449; GO:0038095; GO:0007249; GO:0051059; GO:0050852; GO:0002250; GO:0006921; GO:0006968; GO:0071260; GO:0005881; GO:0005829; GO:0016064; GO:0001772; GO:0045087; GO:0042226; GO:0042109; GO:0005764; GO:0045121; GO:0002906; GO:0001843; GO:0005634; GO:0048471; GO:0005886; GO:0043123; GO:0051092; GO:0050870; GO:0045416; GO:0032765; GO:0042327; GO:0031398; GO:0045893; GO:0051260; GO:0019901; GO:0050856; GO:0009620; GO:0002237; GO:0002224; GO:0003713; GO:0043130 P31749; P20749; Q9BXL7; Q9UDY8 "CBM complex; Fc-epsilon receptor signaling pathway; I-kappaB kinase/NF-kappaB cascade; NF-kappaB binding; T cell receptor signaling pathway; adaptive immune response; cellular component disassembly involved in execution phase of apoptosis; cellular defense response; cellular response to mechanical stimulus; cytoplasmic microtubule; cytosol; immunoglobulin mediated immune response; immunological synapse; innate immune response; interleukin-6 biosynthetic process; lymphotoxin A biosynthetic process; lysosome; membrane raft; negative regulation of mature B cell apoptotic process; neural tube closure; nucleus; perinuclear region of cytoplasm; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell activation; positive regulation of interleukin-8 biosynthetic process; positive regulation of mast cell cytokine production; positive regulation of phosphorylation; positive regulation of protein ubiquitination; positive regulation of transcription, DNA-dependent; protein homooligomerization; protein kinase binding; regulation of T cell receptor signaling pathway; response to fungus; response to molecule of bacterial origin; toll-like receptor signaling pathway; transcription coactivator activity; ubiquitin binding" IPR001315; IPR011029; B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) BCL10 CIPER CLAP Homo sapiens (Human) TR34172_c3_g1_i1 O57422 OPN4B_XENLA 3.00E-32 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR027430; Melanopsin-B (Opsin-4B) (xMOP) opn4b mop Xenopus laevis (African clawed frog) TR34172_c3_g1_i2 Q28509 ADRB2_MACMU 5.00E-29 GO:0007190; GO:0007189; GO:0071875; GO:0016324; GO:0004941; GO:0045453; GO:0050873; GO:0002032; GO:0002024; GO:0031649; GO:0005887; GO:0040015; GO:0045986; GO:0051380; GO:0005634; GO:0043410; GO:0030501; GO:0031398; GO:0045944; GO:0015459; GO:0043235; GO:0006898; GO:0002028; GO:0042312; GO:0009409; GO:0002025 activation of adenylate cyclase activity; adenylate cyclase-activating G-protein coupled receptor signaling pathway; adrenergic receptor signaling pathway; apical plasma membrane; beta2-adrenergic receptor activity; bone resorption; brown fat cell differentiation; desensitization of G-protein coupled receptor protein signaling pathway by arrestin; diet induced thermogenesis; heat generation; integral to plasma membrane; negative regulation of multicellular organism growth; negative regulation of smooth muscle contraction; norepinephrine binding; nucleus; positive regulation of MAPK cascade; positive regulation of bone mineralization; positive regulation of protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter; potassium channel regulator activity; receptor complex; receptor-mediated endocytosis; regulation of sodium ion transport; regulation of vasodilation; response to cold; vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IPR002233; IPR000332; IPR000276; IPR017452; Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) ADRB2 B2AR Macaca mulatta (Rhesus macaque) TR34172_c3_g1_i3 Q5YKK9 OPN4_FELCA 6.00E-33 GO:0005502; GO:0008020; GO:0016021; GO:0007602; GO:0005886; GO:0018298; GO:0042752; GO:0016056; GO:0048511; GO:0007601 11-cis retinal binding; G-protein coupled photoreceptor activity; integral to membrane; phototransduction; plasma membrane; protein-chromophore linkage; regulation of circadian rhythm; rhodopsin mediated signaling pathway; rhythmic process; visual perception IPR000276; IPR017452; IPR001760; IPR027430; Melanopsin (Opsin-4) OPN4 Felis catus (Cat) (Felis silvestris catus) TR34172_c3_g1_i5 O70528 5HT4R_CAVPO 6.00E-30 GO:0005768; GO:0005887; GO:0032098; GO:0004993; GO:0007210; GO:0007268 endosome; integral to plasma membrane; regulation of appetite; serotonin receptor activity; serotonin receptor signaling pathway; synaptic transmission IPR001520; IPR000276; IPR017452; 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) HTR4 Cavia porcellus (Guinea pig) TR34172_c3_g1_i7 O57422 OPN4B_XENLA 2.00E-32 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR027430; Melanopsin-B (Opsin-4B) (xMOP) opn4b mop Xenopus laevis (African clawed frog) TR34172_c3_g1_i8 Q5YKK9 OPN4_FELCA 1.00E-31 GO:0005502; GO:0008020; GO:0016021; GO:0007602; GO:0005886; GO:0018298; GO:0042752; GO:0016056; GO:0048511; GO:0007601 11-cis retinal binding; G-protein coupled photoreceptor activity; integral to membrane; phototransduction; plasma membrane; protein-chromophore linkage; regulation of circadian rhythm; rhodopsin mediated signaling pathway; rhythmic process; visual perception IPR000276; IPR017452; IPR001760; IPR027430; Melanopsin (Opsin-4) OPN4 Felis catus (Cat) (Felis silvestris catus) TR34174_c2_g1_i1 P09087 ABDB_DROME 1.00E-17 GO:0000980; GO:0035225; GO:0035261; GO:0035224; GO:0035263; GO:0007506; GO:0007507; GO:0007486; GO:0030539; GO:0008584; GO:0048094; GO:0007494; GO:0009997; GO:0007621; GO:0045705; GO:0045843; GO:0005634; GO:0007280; GO:1902339; GO:0048087; GO:0045944; GO:0007431; GO:0003700; GO:0007385; GO:0046693; GO:0035277; GO:0060439 "RNA polymerase II distal enhancer sequence-specific DNA binding; determination of genital disc primordium; external genitalia morphogenesis; genital disc anterior/posterior pattern formation; genital disc sexually dimorphic development; gonadal mesoderm development; heart development; imaginal disc-derived female genitalia development; male genitalia development; male gonad development; male pigmentation; midgut development; negative regulation of cardioblast cell fate specification; negative regulation of female receptivity; negative regulation of salivary gland boundary specification; negative regulation of striated muscle tissue development; nucleus; pole cell migration; positive regulation of apoptotic process involved in morphogenesis; positive regulation of developmental pigmentation; positive regulation of transcription from RNA polymerase II promoter; salivary gland development; sequence-specific DNA binding transcription factor activity; specification of segmental identity, abdomen; sperm storage; spiracle morphogenesis, open tracheal system; trachea morphogenesis" IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein abdominal-B (Infraabdominal 7) (IAB-7) (P3) (PH189) Abd-B CG10291 Drosophila melanogaster (Fruit fly) TR34174_c2_g1_i3 P09087 ABDB_DROME 6.00E-17 GO:0000980; GO:0035225; GO:0035261; GO:0035224; GO:0035263; GO:0007506; GO:0007507; GO:0007486; GO:0030539; GO:0008584; GO:0048094; GO:0007494; GO:0009997; GO:0007621; GO:0045705; GO:0045843; GO:0005634; GO:0007280; GO:1902339; GO:0048087; GO:0045944; GO:0007431; GO:0003700; GO:0007385; GO:0046693; GO:0035277; GO:0060439 "RNA polymerase II distal enhancer sequence-specific DNA binding; determination of genital disc primordium; external genitalia morphogenesis; genital disc anterior/posterior pattern formation; genital disc sexually dimorphic development; gonadal mesoderm development; heart development; imaginal disc-derived female genitalia development; male genitalia development; male gonad development; male pigmentation; midgut development; negative regulation of cardioblast cell fate specification; negative regulation of female receptivity; negative regulation of salivary gland boundary specification; negative regulation of striated muscle tissue development; nucleus; pole cell migration; positive regulation of apoptotic process involved in morphogenesis; positive regulation of developmental pigmentation; positive regulation of transcription from RNA polymerase II promoter; salivary gland development; sequence-specific DNA binding transcription factor activity; specification of segmental identity, abdomen; sperm storage; spiracle morphogenesis, open tracheal system; trachea morphogenesis" IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein abdominal-B (Infraabdominal 7) (IAB-7) (P3) (PH189) Abd-B CG10291 Drosophila melanogaster (Fruit fly) TR34174_c2_g1_i4 Q9IA16 HXD12_HETFR 3.00E-16 GO:0007275; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein Hox-D12 HOXD12 Heterodontus francisci (Horn shark) (Cestracion francisci) TR34175_c1_g1_i1 A1L209 AT7L3_DANRE 6.00E-58 GO:0000124; GO:0016568; GO:0046872; GO:0045893; GO:0003713; GO:0006351 "SAGA complex; chromatin modification; metal ion binding; positive regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent" IPR013246; IPR013243; Ataxin-7-like protein 3 (SAGA-associated factor 11 homolog) atxn7l3 si:dz180g5.4 zgc:136438 zgc:158566 Danio rerio (Zebrafish) (Brachydanio rerio) TR34176_c8_g1_i1 Q32KJ6 GALNS_RAT 2.00E-96 GO:0043890; GO:0005764; GO:0046872 N-acetylgalactosamine-6-sulfatase activity; lysosome; metal ion binding IPR017849; IPR017850; IPR000917; IPR024607; N-acetylgalactosamine-6-sulfatase (EC 3.1.6.4) (Chondroitinsulfatase) (Chondroitinase) (Galactose-6-sulfate sulfatase) (N-acetylgalactosamine-6-sulfate sulfatase) (GalNAc6S sulfatase) Galns Rattus norvegicus (Rat) TR34181_c0_g3_i1 Q8CHH5 K0240_MOUSE 1.00E-19 GLTSCR1-like protein Gltscr1l Kiaa0240 Mus musculus (Mouse) TR34183_c0_g2_i1 Q9QVP4 MLRA_MOUSE 6.00E-18 GO:0031672; GO:0005509; GO:0043197; GO:0016459 A band; calcium ion binding; dendritic spine; myosin complex IPR011992; IPR018247; IPR002048; "Myosin regulatory light chain 2, atrial isoform (MLC-2a) (MLC2a) (Myosin light chain 2a) (Myosin regulatory light chain 7)" Myl7 Mylc2a Mus musculus (Mouse) TR34183_c0_g2_i3 Q8STF0 CALM_STRIE 3.00E-90 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Strongylocentrotus intermedius (Sea urchin) TR34183_c0_g2_i4 P14649 MYL6B_HUMAN 1.00E-35 GO:0005509; GO:0005829; GO:0003774; GO:0030049; GO:0005859; GO:0007519; GO:0008307; GO:0016461 Q02440 calcium ion binding; cytosol; motor activity; muscle filament sliding; muscle myosin complex; skeletal muscle tissue development; structural constituent of muscle; unconventional myosin complex IPR011992; IPR002048; Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B) MYL6B MLC1SA Homo sapiens (Human) TR34183_c0_g2_i5 Q8STF0 CALM_STRIE 2.00E-88 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Strongylocentrotus intermedius (Sea urchin) TR34183_c0_g2_i6 P05095 ACTNA_DICDI 1.00E-18 GO:0051764; GO:0005884; GO:0051015; GO:0051017; GO:0005509; GO:0005938; GO:0000331; GO:0007275; GO:0045335; GO:0030674; GO:0005200 "actin crosslink formation; actin filament; actin filament binding; actin filament bundle assembly; calcium ion binding; cell cortex; contractile vacuole; multicellular organismal development; phagocytic vesicle; protein binding, bridging; structural constituent of cytoskeleton" IPR001589; IPR001715; IPR011992; IPR014837; IPR018247; IPR002048; IPR018159; IPR002017; Alpha-actinin A (Actin-binding protein A) (F-actin cross-linking protein) abpA actnA DDB_G0268632 Dictyostelium discoideum (Slime mold) TR34187_c3_g1_i1 Q14590 ZN235_HUMAN 4.00E-51 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) TR34187_c4_g1_i1 P10073 ZSC22_HUMAN 1.00E-47 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 22 (Krueppel-related zinc finger protein 2) (Protein HKR2) (Zinc finger protein 50) ZSCAN22 HKR2 ZNF50 Homo sapiens (Human) TR34187_c5_g1_i1 Q96JB3 HIC2_HUMAN 2.00E-27 GO:0003677; GO:0005925; GO:0046872; GO:0045892; GO:0005634; GO:0005886; GO:0006351 "DNA binding; focal adhesion; metal ion binding; negative regulation of transcription, DNA-dependent; nucleus; plasma membrane; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Hypermethylated in cancer 2 protein (Hic-2) (HIC1-related gene on chromosome 22 protein) (Hic-3) (Zinc finger and BTB domain-containing protein 30) HIC2 HRG22 KIAA1020 ZBTB30 Homo sapiens (Human) TR34187_c5_g2_i1 Q96DT7 ZBT10_HUMAN 4.00E-13 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) ZBTB10 RINZF RINZFC Homo sapiens (Human) TR34187_c6_g3_i1 Q14590 ZN235_HUMAN 6.00E-78 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) TR34187_c6_g3_i2 P17036 ZNF3_HUMAN 4.00E-58 GO:0003677; GO:0030154; GO:0045321; GO:0007275; GO:0005634; GO:0003700; GO:0006351; GO:0008270 Itself; Q9UDV6 "DNA binding; cell differentiation; leukocyte activation; multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 3 (Zinc finger protein HF.12) (Zinc finger protein HZF3.1) (Zinc finger protein KOX25) ZNF3 KOX25 Homo sapiens (Human) TR34187_c6_g3_i3 Q52KB5 ZBT24_DANRE 6.00E-47 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017956; IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450) zbtb24 zfp450 zgc:194556 Danio rerio (Zebrafish) (Brachydanio rerio) TR34187_c6_g4_i1 P41696 AZF1_YEAST 7.00E-23 GO:0000978; GO:0001077; GO:0071322; GO:0005829; GO:0046872; GO:0005634; GO:0060237 RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; cellular response to carbohydrate stimulus; cytosol; metal ion binding; nucleus; regulation of fungal-type cell wall organization IPR007087; IPR015880; IPR013087; Asparagine-rich zinc finger protein AZF1 AZF1 YOR113W O3244 YOR3244W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR34187_c6_g5_i1 Q810A1 ZNF18_MOUSE 2.00E-33 GO:0003677; GO:0046872; GO:0005634; GO:0000981 DNA binding; metal ion binding; nucleus; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR001909; IPR008916; IPR003309; IPR027764; IPR007087; IPR015880; IPR013087; Zinc finger protein 18 (Zinc finger protein 535) (Zinc finger protein with KRAB and SCAN domains 6) Znf18 Zfp535 Zkscan6 Mus musculus (Mouse) TR34187_c6_g6_i1 Q08DS3 OSR1_BOVIN 1.00E-17 GO:0072111; GO:0071300; GO:0002062; GO:0042733; GO:0035115; GO:0035116; GO:0036023; GO:0008406; GO:0007507; GO:0048389; GO:0072143; GO:0072180; GO:0046872; GO:0090094; GO:0072239; GO:0072259; GO:0072162; GO:0072234; GO:0072208; GO:0042474; GO:0043066; GO:0072183; GO:0000122; GO:0003676; GO:0005730; GO:0042476; GO:0060021; GO:0072268; GO:0030501; GO:0050679; GO:2000543; GO:0045944; GO:0048793; GO:0072184; GO:0072168; GO:0072169; GO:0006351; GO:0072190; GO:0001657 "cell proliferation involved in kidney development; cellular response to retinoic acid; chondrocyte differentiation; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic skeletal limb joint morphogenesis; gonad development; heart development; intermediate mesoderm development; mesangial cell development; mesonephric duct morphogenesis; metal ion binding; metanephric cap mesenchymal cell proliferation involved in metanephros development; metanephric glomerulus vasculature development; metanephric interstitial cell development; metanephric mesenchymal cell differentiation; metanephric nephron tubule development; metanephric smooth muscle tissue development; middle ear morphogenesis; negative regulation of apoptotic process; negative regulation of nephron tubule epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; nucleic acid binding; nucleolus; odontogenesis; palate development; pattern specification involved in metanephros development; positive regulation of bone mineralization; positive regulation of epithelial cell proliferation; positive regulation of gastrulation; positive regulation of transcription from RNA polymerase II promoter; pronephros development; renal vesicle progenitor cell differentiation; specification of anterior mesonephric tubule identity; specification of posterior mesonephric tubule identity; transcription, DNA-dependent; ureter urothelium development; ureteric bud development" IPR007087; IPR015880; IPR013087; Protein odd-skipped-related 1 OSR1 ODD1 Bos taurus (Bovine) TR34189_c3_g1_i1 F8VQB6 MYO10_MOUSE 3.00E-06 GO:0005524; GO:0051015; GO:0030898; GO:0005938; GO:0048870; GO:0030705; GO:0005829; GO:0031527; GO:0032433; GO:0030027; GO:0016459; GO:0043005; GO:0043025; GO:0005547; GO:0060002; GO:0022409; GO:0008360; GO:0051489; GO:0001726 P97798 "ATP binding; actin filament binding; actin-dependent ATPase activity; cell cortex; cell motility; cytoskeleton-dependent intracellular transport; cytosol; filopodium membrane; filopodium tip; lamellipodium; myosin complex; neuron projection; neuronal cell body; phosphatidylinositol-3,4,5-trisphosphate binding; plus-end directed microfilament motor activity; positive regulation of cell-cell adhesion; regulation of cell shape; regulation of filopodium assembly; ruffle" IPR019749; IPR014352; IPR019748; IPR000299; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; IPR001849; Unconventional myosin-X (Unconventional myosin-10) Myo10 Mus musculus (Mouse) TR34189_c3_g1_i2 Q86AC8 MYOG_DICDI 2.00E-22 GO:0005524; GO:0003774; GO:0016459 ATP binding; motor activity; myosin complex IPR019749; IPR014352; IPR019748; IPR000299; IPR000048; IPR001609; IPR000857; IPR027417; IPR001452; Myosin-G heavy chain myoG DDB_G0276363 Dictyostelium discoideum (Slime mold) TR34189_c3_g1_i3 Q17LW0 MYO7A_AEDAE 0 GO:0005524; GO:0030048; GO:0030898; GO:0048800; GO:0008407; GO:0005737; GO:0035317; GO:0003774; GO:0016459; GO:0032027; GO:0007605 ATP binding; actin filament-based movement; actin-dependent ATPase activity; antennal morphogenesis; chaeta morphogenesis; cytoplasm; imaginal disc-derived wing hair organization; motor activity; myosin complex; myosin light chain binding; sensory perception of sound IPR019749; IPR014352; IPR019748; IPR000299; IPR018979; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; IPR001452; Myosin-VIIa (Protein crinkled) ck AAEL001220 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR34189_c5_g1_i1 Q17LW0 MYO7A_AEDAE 5.00E-45 GO:0005524; GO:0030048; GO:0030898; GO:0048800; GO:0008407; GO:0005737; GO:0035317; GO:0003774; GO:0016459; GO:0032027; GO:0007605 ATP binding; actin filament-based movement; actin-dependent ATPase activity; antennal morphogenesis; chaeta morphogenesis; cytoplasm; imaginal disc-derived wing hair organization; motor activity; myosin complex; myosin light chain binding; sensory perception of sound IPR019749; IPR014352; IPR019748; IPR000299; IPR018979; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; IPR001452; Myosin-VIIa (Protein crinkled) ck AAEL001220 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR34190_c7_g3_i2 P22072 3BHS2_RAT 1.00E-40 GO:0003854; GO:0005789; GO:0016021; GO:0031966; GO:0006694; GO:0004769 3-beta-hydroxy-delta5-steroid dehydrogenase activity; endoplasmic reticulum membrane; integral to membrane; mitochondrial membrane; steroid biosynthetic process; steroid delta-isomerase activity IPR002225; IPR016040; Lipid metabolism; steroid biosynthesis. 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II) (3-beta-HSD II) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)] Hsd3b Rattus norvegicus (Rat) TR34190_c7_g4_i1 Q4UB16 RAB1_THEAN 3.00E-24 GO:0005525; GO:0005886; GO:0015031; GO:0007264 GTP binding; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-1 (Small GTP-binding protein rab1) rab1 TA18180 Theileria annulata TR34190_c7_g4_i2 Q5RBG1 RAB5B_PONAB 1.00E-23 GO:0019003; GO:0005525; GO:0031901; GO:0030139; GO:0007032; GO:0042470; GO:0005886; GO:0015031; GO:0030100; GO:0007264 GDP binding; GTP binding; early endosome membrane; endocytic vesicle; endosome organization; melanosome; plasma membrane; protein transport; regulation of endocytosis; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-5B RAB5B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34190_c7_g4_i3 P01123 YPT1_YEAST 1.00E-26 GO:0090114; GO:0032258; GO:0005525; GO:0003924; GO:0000139; GO:0005795; GO:0048194; GO:0048211; GO:0000149; GO:0035494; GO:0034498; GO:0032456; GO:0005789; GO:0016236; GO:0000407; GO:0006461; GO:0006890; GO:0007264; GO:0005802 P39958; P53845; P53633; P53093 "COPII-coated vesicle budding; CVT pathway; GTP binding; GTPase activity; Golgi membrane; Golgi stack; Golgi vesicle budding; Golgi vesicle docking; SNARE binding; SNARE complex disassembly; early endosome to Golgi transport; endocytic recycling; endoplasmic reticulum membrane; macroautophagy; pre-autophagosomal structure; protein complex assembly; retrograde vesicle-mediated transport, Golgi to ER; small GTPase mediated signal transduction; trans-Golgi network" IPR027417; IPR005225; IPR001806; IPR003579; GTP-binding protein YPT1 (Protein YP2) (Rab GTPase YPT1) (Transport GTPase YPT1) YPT1 YP2 YFL038C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR34190_c7_g4_i5 A4FV54 RAB8A_BOVIN 4.00E-25 GO:0019003; GO:0005525; GO:0003924; GO:0005794; GO:0048210; GO:0017137; GO:0007409; GO:0032869; GO:0042384; GO:0005932; GO:0031513; GO:0048471; GO:0045335; GO:0030670; GO:0005886; GO:0072659; GO:0015031; GO:0055038; GO:0007264; GO:0006904 GDP binding; GTP binding; GTPase activity; Golgi apparatus; Golgi vesicle fusion to target membrane; Rab GTPase binding; axonogenesis; cellular response to insulin stimulus; cilium assembly; microtubule basal body; nonmotile primary cilium; perinuclear region of cytoplasm; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane; protein localization to plasma membrane; protein transport; recycling endosome membrane; small GTPase mediated signal transduction; vesicle docking involved in exocytosis IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-8A RAB8A Bos taurus (Bovine) TR34191_c0_g1_i1 Q66JD7 ACBD6_XENTR 7.00E-11 GO:0005737; GO:0000062; GO:0008289 cytoplasm; fatty-acyl-CoA binding; lipid binding IPR000582; IPR002110; IPR020683; IPR014352; Acyl-CoA-binding domain-containing protein 6 acbd6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34191_c0_g1_i2 P07108 ACBP_HUMAN 6.00E-34 GO:0005794; GO:0030156; GO:0005783; GO:0000062; GO:0001942; GO:0008289; GO:0005739; GO:0006810; GO:0006641 Golgi apparatus; benzodiazepine receptor binding; endoplasmic reticulum; fatty-acyl-CoA binding; hair follicle development; lipid binding; mitochondrion; transport; triglyceride metabolic process IPR022408; IPR000582; IPR014352; Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP) DBI Homo sapiens (Human) TR34193_c2_g1_i1 Q8IW03 SIAH3_HUMAN 4.00E-53 GO:0046872; GO:0007275; GO:0005634; GO:0006511 metal ion binding; multicellular organismal development; nucleus; ubiquitin-dependent protein catabolic process IPR018121; IPR004162; IPR008974; Seven in absentia homolog 3 (Siah-3) SIAH3 Homo sapiens (Human) TR34193_c2_g1_i2 Q8IUQ4 SIAH1_HUMAN 9.00E-152 GO:0007411; GO:0030877; GO:0007049; GO:0005829; GO:0005769; GO:0051402; GO:0005634; GO:0005886; GO:0043065; GO:2001244; GO:0043161; GO:0031648; GO:0042787; GO:0007283; GO:0004842; GO:0008270 O15265; Q99836; P35372; O43236-6; Q69ZI1; P69713; P98170 axon guidance; beta-catenin destruction complex; cell cycle; cytosol; early endosome; neuron apoptotic process; nucleus; plasma membrane; positive regulation of apoptotic process; positive regulation of intrinsic apoptotic signaling pathway; proteasomal ubiquitin-dependent protein catabolic process; protein destabilization; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; spermatogenesis; ubiquitin-protein ligase activity; zinc ion binding IPR018121; IPR013323; IPR004162; IPR008974; IPR001841; IPR013083; IPR013010; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a) SIAH1 HUMSIAH Homo sapiens (Human) TR34193_c2_g1_i3 Q8IUQ4 SIAH1_HUMAN 2.00E-155 GO:0007411; GO:0030877; GO:0007049; GO:0005829; GO:0005769; GO:0051402; GO:0005634; GO:0005886; GO:0043065; GO:2001244; GO:0043161; GO:0031648; GO:0042787; GO:0007283; GO:0004842; GO:0008270 O15265; Q99836; P35372; O43236-6; Q69ZI1; P69713; P98170 axon guidance; beta-catenin destruction complex; cell cycle; cytosol; early endosome; neuron apoptotic process; nucleus; plasma membrane; positive regulation of apoptotic process; positive regulation of intrinsic apoptotic signaling pathway; proteasomal ubiquitin-dependent protein catabolic process; protein destabilization; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; spermatogenesis; ubiquitin-protein ligase activity; zinc ion binding IPR018121; IPR013323; IPR004162; IPR008974; IPR001841; IPR013083; IPR013010; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a) SIAH1 HUMSIAH Homo sapiens (Human) TR34195_c0_g1_i1 P81612 MYTA_MYTED 3.00E-15 GO:0042742; GO:0051607; GO:0005576; GO:0045087; GO:0050688 defense response to bacterium; defense response to virus; extracellular region; innate immune response; regulation of defense response to virus Mytilin-A Mytilus edulis (Blue mussel) TR34195_c2_g2_i1 P81613 MYTB_MYTED 1.00E-14 GO:0042742; GO:0051607; GO:0005576; GO:0045087; GO:0050688 defense response to bacterium; defense response to virus; extracellular region; innate immune response; regulation of defense response to virus IPR019631; Mytilin-B Mytilus edulis (Blue mussel) TR34196_c1_g1_i2 E1BY51 TMM17_CHICK 1.00E-29 GO:0036038; GO:0042384; GO:0060170; GO:0016021; GO:0007224 TCTN-B9D complex; cilium assembly; cilium membrane; integral to membrane; smoothened signaling pathway IPR019184; Transmembrane protein 17 TMEM17 Gallus gallus (Chicken) TR34196_c1_g1_i3 Q5HZE5 TMM17_RAT 3.00E-24 GO:0036038; GO:0042384; GO:0060170; GO:0016021; GO:0007224 TCTN-B9D complex; cilium assembly; cilium membrane; integral to membrane; smoothened signaling pathway IPR019184; Transmembrane protein 17 Tmem17 Rattus norvegicus (Rat) TR34196_c1_g1_i5 A5D6V4 TM17B_DANRE 5.00E-27 GO:0036038; GO:0042384; GO:0060170; GO:0016021; GO:0007224 TCTN-B9D complex; cilium assembly; cilium membrane; integral to membrane; smoothened signaling pathway IPR019184; Transmembrane protein 17B Tmem17b zgc:163141 Danio rerio (Zebrafish) (Brachydanio rerio) TR34198_c0_g3_i1 Q8BTZ7 GMPPB_MOUSE 0 GO:0009298; GO:0005525; GO:0004475; GO:0005739 GDP-mannose biosynthetic process; GTP binding; mannose-1-phosphate guanylyltransferase activity; mitochondrion IPR001451; IPR018357; IPR005835; Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1. Mannose-1-phosphate guanyltransferase beta (EC 2.7.7.13) (GDP-mannose pyrophosphorylase B) (GTP-mannose-1-phosphate guanylyltransferase beta) Gmppb Mus musculus (Mouse) TR34200_c3_g1_i1 Q8AWF2 NACA_ORENI 5.00E-71 GO:0015031 protein transport IPR016641; IPR002715; IPR000449; Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) naca Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) TR34204_c3_g1_i1 Q9H898 ZMAT4_HUMAN 7.00E-08 GO:0003677; GO:0005634; GO:0008270 DNA binding; nucleus; zinc ion binding IPR007087; IPR015880; IPR022755; IPR003604; Zinc finger matrin-type protein 4 ZMAT4 Homo sapiens (Human) TR34204_c3_g1_i2 Q9H898 ZMAT4_HUMAN 7.00E-08 GO:0003677; GO:0005634; GO:0008270 DNA binding; nucleus; zinc ion binding IPR007087; IPR015880; IPR022755; IPR003604; Zinc finger matrin-type protein 4 ZMAT4 Homo sapiens (Human) TR34205_c0_g1_i1 Q96DB5 RMD1_HUMAN 2.00E-79 GO:0005813; GO:0005874; GO:0005739; GO:0000922 centrosome; microtubule; mitochondrion; spindle pole IPR011990; Regulator of microtubule dynamics protein 1 (RMD-1) (hRMD-1) (Protein FAM82B) RMDN1 FAM82B CGI-90 Homo sapiens (Human) TR34206_c1_g1_i1 Q8VBW5 BBX_MOUSE 7.00E-33 GO:0003677; GO:0060348; GO:0005634; GO:0006355; GO:0006351 "DNA binding; bone development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009071; IPR019102; HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) Bbx Hbp2 Mus musculus (Mouse) TR34207_c0_g2_i4 Q9D4C1 ILFT1_MOUSE 1.00E-18 GO:0008283; GO:0005737; GO:0005882; GO:0005635; GO:0005198 cell proliferation; cytoplasm; intermediate filament; nuclear envelope; structural molecule activity IPR001664; IPR001322; Intermediate filament tail domain-containing protein 1 (Lamin-A-related sequence 1 protein) Ifltd1 Lmna-rs1 Mus musculus (Mouse) TR34207_c0_g2_i5 Q4R899 ILFT1_MACFA 8.00E-22 GO:0005882; GO:0005198 intermediate filament; structural molecule activity IPR001664; IPR001322; Intermediate filament tail domain-containing protein 1 IFLTD1 QtsA-13030 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR34210_c10_g1_i1 Q8IV45 UN5CL_HUMAN 1.00E-09 GO:0005737; GO:0016021; GO:0007165 cytoplasm; integral to membrane; signal transduction IPR011029; IPR000488; IPR000906; UNC5C-like protein (Protein unc-5 homolog C-like) (ZU5 and death domain-containing protein) UNC5CL ZUD Homo sapiens (Human) TR34210_c2_g1_i1 B3TP03 CTR2_CHICK 4.00E-43 GO:0015171; GO:0016021 amino acid transmembrane transporter activity; integral to membrane IPR002293; IPR004755; Low affinity cationic amino acid transporter 2 (CAT-2) (CAT2) (cCAT-2) (Solute carrier family 7 member 2) SLC7A2 ATRC2 CAT2 Gallus gallus (Chicken) TR34210_c4_g1_i1 P30825 CTR1_HUMAN 1.00E-44 GO:0006865; GO:0015181; GO:0005887; GO:0055085 amino acid transport; arginine transmembrane transporter activity; integral to plasma membrane; transmembrane transport IPR002293; IPR004755; High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homolog) (Ecotropic retrovirus receptor homolog) (ERR) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter) SLC7A1 ATRC1 ERR REC1L Homo sapiens (Human) TR34210_c4_g1_i2 Q8GYB4 CAAT3_ARATH 1.00E-21 GO:0015171; GO:0016021; GO:0031966 amino acid transmembrane transporter activity; integral to membrane; mitochondrial membrane IPR002293; "Cationic amino acid transporter 3, mitochondrial" CAT3 At5g36940 MLF18.60 Arabidopsis thaliana (Mouse-ear cress) TR34210_c8_g1_i1 Q09143 CTR1_MOUSE 5.00E-55 GO:0015181; GO:0016021 arginine transmembrane transporter activity; integral to membrane IPR002293; IPR004755; High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor) (Ecotropic retrovirus receptor) (ERR) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter) Slc7a1 Atrc1 Rec-1 Mus musculus (Mouse) TR34212_c0_g1_i1 Q8BNJ6 NETO2_MOUSE 6.00E-06 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR000859; IPR023415; IPR002172; Neuropilin and tolloid-like protein 2 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2) Neto2 Btcl2 Mus musculus (Mouse) TR34212_c1_g4_i1 Q69ZQ1 K1161_MOUSE 5.00E-37 GO:0005975; GO:0004553; GO:0016021; GO:0031965; GO:0043568; GO:0051897; GO:0048741 "carbohydrate metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; integral to membrane; nuclear membrane; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of protein kinase B signaling cascade; skeletal muscle fiber development" IPR013785; IPR000322; IPR017853; Uncharacterized family 31 glucosidase KIAA1161 (EC 3.2.1.-) Kiaa1161 Mus musculus (Mouse) TR34213_c6_g1_i1 O60100 IMB4_SCHPO 2.00E-27 GO:0005829; GO:0005643; GO:0006913; GO:0006605; GO:0008565 cytosol; nuclear pore; nucleocytoplasmic transport; protein targeting; protein transporter activity IPR011989; IPR016024; IPR000357; IPR021133; IPR001494; Probable importin subunit beta-4 (Importin-123) (Karyopherin subunit beta-4) (Karyopherin-123) kap123 SPBC14F5.03c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR34213_c6_g2_i2 Q8TEX9 IPO4_HUMAN 9.00E-116 GO:0005737; GO:0006886; GO:0005634; GO:0015031 cytoplasm; intracellular protein transport; nucleus; protein transport IPR011989; IPR016024; IPR021133; IPR001494; Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4) IPO4 IMP4B RANBP4 Homo sapiens (Human) TR34213_c6_g2_i3 Q8BIV3 RNBP6_MOUSE 4.00E-06 GO:0005737; GO:0005634; GO:0015031 cytoplasm; nucleus; protein transport IPR011989; IPR016024; IPR000357; Ran-binding protein 6 (RanBP6) Ranbp6 Mus musculus (Mouse) TR34214_c2_g3_i2 Q9CZQ9 BBS5_MOUSE 0 GO:0034464; GO:0036064; GO:0060170; GO:0005737 BBSome; cilium basal body; cilium membrane; cytoplasm IPR006606; Bardet-Biedl syndrome 5 protein homolog Bbs5 Mus musculus (Mouse) TR34215_c2_g1_i1 Q9MYM7 B3GT1_PONPY 4.00E-39 GO:0000139; GO:0008378; GO:0016021; GO:0006486 Golgi membrane; galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) TR34217_c4_g1_i1 Q5R8Z8 RAB14_PONAB 6.00E-30 GO:0019003; GO:0005525; GO:0003924; GO:0000139; GO:0006895; GO:0031901; GO:0009790; GO:0032456; GO:0008543; GO:0045335; GO:0030670; GO:0015031; GO:0055037; GO:0032880; GO:0007264 GDP binding; GTP binding; GTPase activity; Golgi membrane; Golgi to endosome transport; early endosome membrane; embryo development; endocytic recycling; fibroblast growth factor receptor signaling pathway; phagocytic vesicle; phagocytic vesicle membrane; protein transport; recycling endosome; regulation of protein localization; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-14 RAB14 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34217_c4_g1_i10 A4D1S5 RAB19_HUMAN 8.00E-30 GO:0005525; GO:0005886; GO:0015031; GO:0007264 GTP binding; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-19 RAB19 RAB19B Homo sapiens (Human) TR34217_c4_g1_i11 Q40521 RB11B_TOBAC 2.00E-34 GO:0005525; GO:0005886; GO:0015031; GO:0007264 GTP binding; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab11B RAB11B Nicotiana tabacum (Common tobacco) TR34217_c4_g1_i13 P18067 RAB7A_CANFA 1.00E-121 GO:0005525; GO:0003924; GO:0005794; GO:0045022; GO:0008333; GO:0007174; GO:0005770; GO:0005764; GO:0042470; GO:0045335; GO:0030670; GO:0090383; GO:0090385; GO:0006622; GO:0007264 GTP binding; GTPase activity; Golgi apparatus; early endosome to late endosome transport; endosome to lysosome transport; epidermal growth factor catabolic process; late endosome; lysosome; melanosome; phagocytic vesicle; phagocytic vesicle membrane; phagosome acidification; phagosome-lysosome fusion; protein targeting to lysosome; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-7a RAB7A RAB7 Canis familiaris (Dog) (Canis lupus familiaris) TR34217_c4_g1_i2 P18067 RAB7A_CANFA 1.00E-121 GO:0005525; GO:0003924; GO:0005794; GO:0045022; GO:0008333; GO:0007174; GO:0005770; GO:0005764; GO:0042470; GO:0045335; GO:0030670; GO:0090383; GO:0090385; GO:0006622; GO:0007264 GTP binding; GTPase activity; Golgi apparatus; early endosome to late endosome transport; endosome to lysosome transport; epidermal growth factor catabolic process; late endosome; lysosome; melanosome; phagocytic vesicle; phagocytic vesicle membrane; phagosome acidification; phagosome-lysosome fusion; protein targeting to lysosome; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-7a RAB7A RAB7 Canis familiaris (Dog) (Canis lupus familiaris) TR34217_c4_g1_i3 Q40723 RLGP2_ORYSJ 3.00E-32 GO:0005525; GO:0005886; GO:0015031; GO:0007264 GTP binding; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein RGP2 (GTP-binding regulatory protein RGP2) RGP2 Os05g0280200 LOC_Os05g20050 P0048F12.8 Oryza sativa subsp. japonica (Rice) TR34217_c4_g1_i4 Q06AU5 RAB32_PIG 3.00E-28 GO:0005525; GO:0005739; GO:0045335; GO:0030670; GO:0090382; GO:0015031; GO:0007264 GTP binding; mitochondrion; phagocytic vesicle; phagocytic vesicle membrane; phagosome maturation; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-32 RAB32 Sus scrofa (Pig) TR34217_c4_g1_i5 Q9NP72 RAB18_HUMAN 1.00E-30 GO:0019003; GO:0005525; GO:0003924; GO:0007420; GO:0006897; GO:0001654; GO:0005622; GO:0005886; GO:0015031; GO:0007264 Q99IB8 GDP binding; GTP binding; GTPase activity; brain development; endocytosis; eye development; intracellular; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR025662; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-18 RAB18 Homo sapiens (Human) TR34217_c4_g1_i6 Q29RR0 RAB26_BOVIN 2.00E-28 GO:0019002; GO:0005525; GO:0000139; GO:0043001; GO:0035272; GO:0031226; GO:0045055; GO:0017157; GO:0030667; GO:0007264 GMP binding; GTP binding; Golgi membrane; Golgi to plasma membrane protein transport; exocrine system development; intrinsic to plasma membrane; regulated secretory pathway; regulation of exocytosis; secretory granule membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-26 RAB26 Bos taurus (Bovine) TR34217_c4_g1_i8 P18067 RAB7A_CANFA 3.00E-124 GO:0005525; GO:0003924; GO:0005794; GO:0045022; GO:0008333; GO:0007174; GO:0005770; GO:0005764; GO:0042470; GO:0045335; GO:0030670; GO:0090383; GO:0090385; GO:0006622; GO:0007264 GTP binding; GTPase activity; Golgi apparatus; early endosome to late endosome transport; endosome to lysosome transport; epidermal growth factor catabolic process; late endosome; lysosome; melanosome; phagocytic vesicle; phagocytic vesicle membrane; phagosome acidification; phagosome-lysosome fusion; protein targeting to lysosome; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-7a RAB7A RAB7 Canis familiaris (Dog) (Canis lupus familiaris) TR34217_c4_g1_i9 P17609 YPT2_SCHPO 4.00E-31 GO:0005525; GO:0003924; GO:0006893; GO:0005829; GO:0006887; GO:0006886; GO:0005634; GO:0005886; GO:0007264; GO:0006906 GTP binding; GTPase activity; Golgi to plasma membrane transport; cytosol; exocytosis; intracellular protein transport; nucleus; plasma membrane; small GTPase mediated signal transduction; vesicle fusion IPR027417; IPR005225; IPR001806; IPR003579; GTP-binding protein ypt2 (SEC4 homolog) ypt2 SPAC9E9.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR34218_c1_g1_i1 P49109 FMO5_CAVPO 3.00E-125 GO:0004499; GO:0050661; GO:0005789; GO:0050660; GO:0016021 "N,N-dimethylaniline monooxygenase activity; NADP binding; endoplasmic reticulum membrane; flavin adenine dinucleotide binding; integral to membrane" IPR012143; IPR000960; IPR020946; IPR002257; IPR016040; Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5) FMO5 Cavia porcellus (Guinea pig) TR34218_c1_g2_i1 P49326 FMO5_HUMAN 1.00E-58 GO:0004499; GO:0050661; GO:0005789; GO:0050660; GO:0016021; GO:0043231 "N,N-dimethylaniline monooxygenase activity; NADP binding; endoplasmic reticulum membrane; flavin adenine dinucleotide binding; integral to membrane; intracellular membrane-bounded organelle" IPR012143; IPR000960; IPR020946; IPR002257; IPR016040; Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5) FMO5 Homo sapiens (Human) TR34219_c3_g1_i1 Q6R7C4 IAP4_OSHVF 9.00E-06 GO:0008270 zinc ion binding IPR001370; IPR001841; IPR013083; Putative apoptosis inhibitor ORF106 ORF106 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) TR34219_c4_g1_i2 Q24307 IAP2_DROME 8.00E-10 GO:0050829; GO:0043066; GO:0043154; GO:0061057; GO:0006964; GO:0033160; GO:0070534; GO:0007423; GO:0008270 "defense response to Gram-negative bacterium; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; peptidoglycan recognition protein signaling pathway; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; positive regulation of protein import into nucleus, translocation; protein K63-linked ubiquitination; sensory organ development; zinc ion binding" IPR001370; IPR001841; IPR013083; Apoptosis 2 inhibitor (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) (dIAP2) Iap2 DIHA ILP CG8293 Drosophila melanogaster (Fruit fly) TR34219_c4_g1_i4 Q8JHV9 BIR7A_XENLA 6.00E-11 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR34219_c4_g1_i5 Q13075 BIRC1_HUMAN 2.00E-09 GO:0005524; GO:0016323; GO:0004869; GO:0005737; GO:0006954; GO:0045087; GO:0046872; GO:0043154; GO:0043524; GO:0007399; GO:0017111 ATP binding; basolateral plasma membrane; cysteine-type endopeptidase inhibitor activity; cytoplasm; inflammatory response; innate immune response; metal ion binding; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of neuron apoptotic process; nervous system development; nucleoside-triphosphatase activity IPR003593; IPR001370; IPR007111; IPR027417; Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein) NAIP BIRC1 Homo sapiens (Human) TR34220_c2_g1_i1 O15360 FANCA_HUMAN 6.00E-99 GO:0006281; GO:0043240; GO:0005737; GO:0008585; GO:0008584; GO:0007140; GO:0006461; GO:0042127 Q0VG06; Q9NPI8; O15287; P62993 DNA repair; Fanconi anaemia nuclear complex; cytoplasm; female gonad development; male gonad development; male meiosis; protein complex assembly; regulation of cell proliferation IPR003516; Fanconi anemia group A protein (Protein FACA) FANCA FAA FACA FANCH Homo sapiens (Human) TR34220_c2_g1_i4 O15360 FANCA_HUMAN 7.00E-99 GO:0006281; GO:0043240; GO:0005737; GO:0008585; GO:0008584; GO:0007140; GO:0006461; GO:0042127 Q0VG06; Q9NPI8; O15287; P62993 DNA repair; Fanconi anaemia nuclear complex; cytoplasm; female gonad development; male gonad development; male meiosis; protein complex assembly; regulation of cell proliferation IPR003516; Fanconi anemia group A protein (Protein FACA) FANCA FAA FACA FANCH Homo sapiens (Human) TR34220_c2_g1_i6 O15360 FANCA_HUMAN 4.00E-97 GO:0006281; GO:0043240; GO:0005737; GO:0008585; GO:0008584; GO:0007140; GO:0006461; GO:0042127 Q0VG06; Q9NPI8; O15287; P62993 DNA repair; Fanconi anaemia nuclear complex; cytoplasm; female gonad development; male gonad development; male meiosis; protein complex assembly; regulation of cell proliferation IPR003516; Fanconi anemia group A protein (Protein FACA) FANCA FAA FACA FANCH Homo sapiens (Human) TR34221_c0_g3_i1 Q8R2K1 FUCM_MOUSE 4.00E-42 GO:0042806; GO:0006004; GO:0016857 "fucose binding; fucose metabolic process; racemase and epimerase activity, acting on carbohydrates and derivatives" IPR023750; IPR007721; Fucose mutarotase (EC 5.1.3.n2) Fuom Le51 Mus musculus (Mouse) TR34221_c0_g3_i2 A2VDF0 FUCM_HUMAN 3.00E-41 GO:0042806; GO:0006004; GO:0016857 "fucose binding; fucose metabolic process; racemase and epimerase activity, acting on carbohydrates and derivatives" IPR023750; IPR007721; Fucose mutarotase (EC 5.1.3.n2) FUOM C10orf125 Homo sapiens (Human) TR34222_c2_g1_i2 O01346 EGH_DROME 2.00E-113 GO:0007411; GO:0019187; GO:0007298; GO:0045165; GO:0033227; GO:0006688; GO:0016021; GO:0042248; GO:0008049; GO:0045434; GO:0030720; GO:0016325; GO:0001744; GO:0007299; GO:0046662 "axon guidance; beta-1,4-mannosyltransferase activity; border follicle cell migration; cell fate commitment; dsRNA transport; glycosphingolipid biosynthetic process; integral to membrane; maintenance of polarity of follicular epithelium; male courtship behavior; negative regulation of female receptivity, post-mating; oocyte localization involved in germarium-derived egg chamber formation; oocyte microtubule cytoskeleton organization; optic lobe placode formation; ovarian follicle cell-cell adhesion; regulation of oviposition" IPR027389; "Beta-1,4-mannosyltransferase egh (EC 2.4.1.-) (Protein egghead) (Protein zeste-white 4)" egh l(1)3Ae zw4 CG9659 Drosophila melanogaster (Fruit fly) TR34223_c0_g3_i3 Q14185 DOCK1_HUMAN 0 GO:0038096; GO:0005096; GO:0006915; GO:0007411; GO:0007596; GO:0016477; GO:0005829; GO:0005085; GO:0045087; GO:0007229; GO:0016020; GO:0006911; GO:0007264 O15084; Q92556; P62993; P63000 "Fc-gamma receptor signaling pathway involved in phagocytosis; GTPase activator activity; apoptotic process; axon guidance; blood coagulation; cell migration; cytosol; guanyl-nucleotide exchange factor activity; innate immune response; integrin-mediated signaling pathway; membrane; phagocytosis, engulfment; small GTPase mediated signal transduction" IPR016024; IPR027007; IPR027357; IPR026791; IPR010703; IPR001452; Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) DOCK1 Homo sapiens (Human) TR34223_c0_g3_i5 Q14185 DOCK1_HUMAN 0 GO:0038096; GO:0005096; GO:0006915; GO:0007411; GO:0007596; GO:0016477; GO:0005829; GO:0005085; GO:0045087; GO:0007229; GO:0016020; GO:0006911; GO:0007264 O15084; Q92556; P62993; P63000 "Fc-gamma receptor signaling pathway involved in phagocytosis; GTPase activator activity; apoptotic process; axon guidance; blood coagulation; cell migration; cytosol; guanyl-nucleotide exchange factor activity; innate immune response; integrin-mediated signaling pathway; membrane; phagocytosis, engulfment; small GTPase mediated signal transduction" IPR016024; IPR027007; IPR027357; IPR026791; IPR010703; IPR001452; Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) DOCK1 Homo sapiens (Human) TR34223_c0_g3_i7 Q8BUR4 DOCK1_MOUSE 0 GO:0006915; GO:0016477; GO:0005737; GO:0005085; GO:0016020; GO:0006909; GO:0007264 Q8BPU7-1; Q8BYZ7; Q8C0C0 apoptotic process; cell migration; cytoplasm; guanyl-nucleotide exchange factor activity; membrane; phagocytosis; small GTPase mediated signal transduction IPR016024; IPR027007; IPR027357; IPR026791; IPR010703; IPR001452; Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) Dock1 Mus musculus (Mouse) TR34223_c0_g4_i4 Q3T0L7 RL28_BOVIN 7.00E-44 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR002672; 60S ribosomal protein L28 RPL28 Bos taurus (Bovine) TR34224_c1_g1_i1 Q7SXF6 CREL2_DANRE 1.00E-86 GO:0005509; GO:0005783; GO:0005576 calcium ion binding; endoplasmic reticulum; extracellular region IPR021852; IPR000742; IPR001881; IPR013032; IPR018097; IPR002049; IPR006212; IPR009030; Cysteine-rich with EGF-like domain protein 2 creld2 zgc:66383 Danio rerio (Zebrafish) (Brachydanio rerio) TR34224_c1_g1_i2 O70244 CUBN_RAT 2.00E-06 GO:0031526; GO:0005509; GO:0008203; GO:0031419; GO:0030666; GO:0010008; GO:0030492; GO:0020028; GO:0042802; GO:0001701; GO:0043202; GO:0005765; GO:0043234; GO:0070207; GO:0004872; GO:0006898; GO:0007584; GO:0006766 Itself brush border membrane; calcium ion binding; cholesterol metabolic process; cobalamin binding; endocytic vesicle membrane; endosome membrane; hemoglobin binding; hemoglobin import; identical protein binding; in utero embryonic development; lysosomal lumen; lysosomal membrane; protein complex; protein homotrimerization; receptor activity; receptor-mediated endocytosis; response to nutrient; vitamin metabolic process IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; Cubilin (460 kDa receptor) (Glycoprotein 280) (gp280) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) Cubn Ifcr Rattus norvegicus (Rat) TR34224_c1_g1_i3 Q61001 LAMA5_MOUSE 1.00E-06 GO:0060445; GO:0001658; GO:0042384; GO:0090002; GO:0005615; GO:0001942; GO:0005178; GO:0007229; GO:0005606; GO:0043259; GO:0030324; GO:0001738; GO:0016331; GO:0007517; GO:0001755; GO:0042475; GO:0030155; GO:0030334; GO:0042127; GO:0045995; GO:0034446 branching involved in salivary gland morphogenesis; branching involved in ureteric bud morphogenesis; cilium assembly; establishment of protein localization to plasma membrane; extracellular space; hair follicle development; integrin binding; integrin-mediated signaling pathway; laminin-1 complex; laminin-10 complex; lung development; morphogenesis of a polarized epithelium; morphogenesis of embryonic epithelium; muscle organ development; neural crest cell migration; odontogenesis of dentin-containing tooth; regulation of cell adhesion; regulation of cell migration; regulation of cell proliferation; regulation of embryonic development; substrate adhesion-dependent cell spreading IPR008985; IPR013320; IPR013032; IPR002049; IPR018031; IPR000034; IPR001791; IPR009254; IPR010307; IPR008211; Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha) Lama5 Mus musculus (Mouse) TR34225_c1_g1_i1 A0JP70 WDR90_XENTR 5.00E-102 IPR007714; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 90 wdr90 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34225_c2_g1_i2 O61585 KTNB1_STRPU 3.00E-06 GO:0051301; GO:0008352; GO:0005874; GO:0051013; GO:0007067; GO:0000922 cell division; katanin complex; microtubule; microtubule severing; mitosis; spindle pole IPR020472; IPR026962; IPR028021; IPR015943; IPR001680; IPR019775; IPR017986; Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) KATNB1 Strongylocentrotus purpuratus (Purple sea urchin) TR34225_c2_g1_i3 A0JP70 WDR90_XENTR 3.00E-42 IPR007714; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 90 wdr90 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34226_c3_g1_i1 P08548 LIN1_NYCCO 6.00E-21 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR34227_c11_g1_i1 Q0V8R6 HEXA_BOVIN 1.00E-08 GO:0007628; GO:0004563; GO:0005975; GO:0048667; GO:0006689; GO:0030203; GO:0019915; GO:0005764; GO:0007040; GO:0016020; GO:0042552; GO:0050885; GO:0050884; GO:0007605; GO:0019953; GO:0001501 adult walking behavior; beta-N-acetylhexosaminidase activity; carbohydrate metabolic process; cell morphogenesis involved in neuron differentiation; ganglioside catabolic process; glycosaminoglycan metabolic process; lipid storage; lysosome; lysosome organization; membrane; myelination; neuromuscular process controlling balance; neuromuscular process controlling posture; sensory perception of sound; sexual reproduction; skeletal system development IPR025705; IPR015883; IPR013781; IPR017853; Beta-hexosaminidase subunit alpha (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit alpha) (Hexosaminidase subunit A) (N-acetyl-beta-glucosaminidase subunit alpha) HEXA Bos taurus (Bovine) TR34227_c9_g1_i2 Q9VB74 U396_DROME 1.00E-50 GO:0071013; GO:0000398; GO:0022008 "catalytic step 2 spliceosome; mRNA splicing, via spliceosome; neurogenesis" IPR009269; UPF0396 protein CG6066 CG6066 Drosophila melanogaster (Fruit fly) TR34229_c0_g1_i1 Q5RJU3 CC103_XENTR 3.00E-46 GO:0030030; GO:0005929; GO:0005737 cell projection organization; cilium; cytoplasm IPR025986; Coiled-coil domain-containing protein 103 ccdc103 TNeu101c05.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34229_c0_g1_i3 Q8IW40 CC103_HUMAN 1.00E-47 GO:0030030; GO:0035085; GO:0071907; GO:0060287; GO:0001947; GO:0036159; GO:0036158; GO:0042803 cell projection organization; cilium axoneme; determination of digestive tract left/right asymmetry; epithelial cilium movement involved in determination of left/right asymmetry; heart looping; inner dynein arm assembly; outer dynein arm assembly; protein homodimerization activity IPR025986; Coiled-coil domain-containing protein 103 CCDC103 Homo sapiens (Human) TR34229_c0_g1_i4 Q9D9P2 CC103_MOUSE 5.00E-49 GO:0030030; GO:0005929; GO:0003341; GO:0005737; GO:0071907; GO:0001947; GO:0036159; GO:0036158 cell projection organization; cilium; cilium movement; cytoplasm; determination of digestive tract left/right asymmetry; heart looping; inner dynein arm assembly; outer dynein arm assembly IPR025986; Coiled-coil domain-containing protein 103 Ccdc103 Mus musculus (Mouse) TR34233_c0_g2_i1 O60290 ZN862_HUMAN 2.00E-16 GO:0046872; GO:0003676; GO:0005634; GO:0006355; GO:0006351 "metal ion binding; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR008906; IPR026613; IPR001909; IPR012337; IPR006580; Zinc finger protein 862 ZNF862 KIAA0543 Homo sapiens (Human) TR34233_c2_g1_i1 Q60SG7 XRN2_CAEBR 0 GO:0008409; GO:0004534; GO:0000738; GO:0006353; GO:0006397; GO:0003676; GO:0005730; GO:0006355; GO:0008270 "5'-3' exonuclease activity; 5'-3' exoribonuclease activity; DNA catabolic process, exonucleolytic; DNA-dependent transcription, termination; mRNA processing; nucleic acid binding; nucleolus; regulation of transcription, DNA-dependent; zinc ion binding" IPR027073; IPR017151; IPR004859; IPR001878; 5'-3' exoribonuclease 2 homolog (EC 3.1.13.-) xrn-2 CBG20900 Caenorhabditis briggsae TR34233_c2_g1_i3 Q5ZIP4 XRN2_CHICK 0 GO:0008409; GO:0004534; GO:0000738; GO:0006353; GO:0016049; GO:0006397; GO:0003676; GO:0005730; GO:0006355; GO:0007283; GO:0008270 "5'-3' exonuclease activity; 5'-3' exoribonuclease activity; DNA catabolic process, exonucleolytic; DNA-dependent transcription, termination; cell growth; mRNA processing; nucleic acid binding; nucleolus; regulation of transcription, DNA-dependent; spermatogenesis; zinc ion binding" IPR027073; IPR017151; IPR004859; IPR001878; 5'-3' exoribonuclease 2 (EC 3.1.13.-) XRN2 RCJMB04_24h23 Gallus gallus (Chicken) TR34233_c2_g1_i4 Q5ZIP4 XRN2_CHICK 0 GO:0008409; GO:0004534; GO:0000738; GO:0006353; GO:0016049; GO:0006397; GO:0003676; GO:0005730; GO:0006355; GO:0007283; GO:0008270 "5'-3' exonuclease activity; 5'-3' exoribonuclease activity; DNA catabolic process, exonucleolytic; DNA-dependent transcription, termination; cell growth; mRNA processing; nucleic acid binding; nucleolus; regulation of transcription, DNA-dependent; spermatogenesis; zinc ion binding" IPR027073; IPR017151; IPR004859; IPR001878; 5'-3' exoribonuclease 2 (EC 3.1.13.-) XRN2 RCJMB04_24h23 Gallus gallus (Chicken) TR34234_c3_g1_i1 Q9P2P5 HECW2_HUMAN 6.00E-23 GO:0005737; GO:0005634; GO:0042787; GO:0004842 cytoplasm; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000008; IPR000569; IPR001202; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase HECW2 (EC 6.3.2.-) (HECT, C2 and WW domain-containing protein 2) (NEDD4-like E3 ubiquitin-protein ligase 2)" HECW2 KIAA1301 NEDL2 Homo sapiens (Human) TR34234_c3_g2_i1 Q9VVI3 NEDD4_DROME 5.00E-19 GO:0007219; GO:0016199; GO:0005737; GO:0045746; GO:0007528; GO:0005886; GO:0002092; GO:0051965; GO:0019904; GO:0031623; GO:0004842 Notch signaling pathway; axon midline choice point recognition; cytoplasm; negative regulation of Notch signaling pathway; neuromuscular junction development; plasma membrane; positive regulation of receptor internalization; positive regulation of synapse assembly; protein domain specific binding; receptor internalization; ubiquitin-protein ligase activity IPR000008; IPR000569; IPR001202; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase Nedd-4 (DNedd4) (EC 6.3.2.-) Nedd4 CG7555 Drosophila melanogaster (Fruit fly) TR34234_c7_g2_i1 Q9ES34 UBE3B_MOUSE 3.00E-72 GO:0005737; GO:0005634; GO:0042787; GO:0004842 cytoplasm; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000569; IPR000048; Protein modification; protein ubiquitination. Ubiquitin-protein ligase E3B (EC 6.3.2.-) Ube3b Mus musculus (Mouse) TR34234_c8_g1_i4 Q9ES34 UBE3B_MOUSE 1.00E-27 GO:0005737; GO:0005634; GO:0042787; GO:0004842 cytoplasm; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000569; IPR000048; Protein modification; protein ubiquitination. Ubiquitin-protein ligase E3B (EC 6.3.2.-) Ube3b Mus musculus (Mouse) TR34235_c0_g1_i1 Q9UUE2 CSX2_SCHPO 1.00E-14 GO:0008060; GO:0005829; GO:0006886; GO:0005543; GO:0005886; GO:0043547; GO:0032312; GO:0008270 ARF GTPase activator activity; cytosol; intracellular protein transport; phospholipid binding; plasma membrane; positive regulation of GTPase activity; regulation of ARF GTPase activity; zinc ion binding IPR027267; IPR001164; IPR011993; IPR001849; Protein csx2 csx2 SPBC17G9.08c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR34235_c0_g2_i1 P32572 SPS18_YEAST 4.00E-13 GO:0008060; GO:0043547; GO:0032312; GO:0030435; GO:0008270 ARF GTPase activator activity; positive regulation of GTPase activity; regulation of ARF GTPase activity; sporulation resulting in formation of a cellular spore; zinc ion binding IPR001164; Sporulation protein SPS18 (Sporulation-specific protein SPX18) SPS18 SPX18 YNL204C N1354 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR34235_c0_g3_i1 Q5ZK62 ACAP2_CHICK 1.00E-21 GO:0008060; GO:1990090; GO:0010008; GO:0005543; GO:0043547; GO:0036010; GO:0032312; GO:0008270 ARF GTPase activator activity; cellular response to nerve growth factor stimulus; endosome membrane; phospholipid binding; positive regulation of GTPase activity; protein localization to endosome; regulation of ARF GTPase activity; zinc ion binding IPR027267; IPR002110; IPR020683; IPR001164; IPR011993; IPR001849; "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2)" ACAP2 CENTB2 RCJMB04_12p24 Gallus gallus (Chicken) TR34235_c0_g3_i2 O75689 ADAP1_HUMAN 1.00E-84 GO:0008060; GO:0007166; GO:0005737; GO:0043533; GO:0005634; GO:0005543; GO:0005886; GO:0032312; GO:0008270 "ARF GTPase activator activity; cell surface receptor signaling pathway; cytoplasm; inositol 1,3,4,5 tetrakisphosphate binding; nucleus; phospholipid binding; plasma membrane; regulation of ARF GTPase activity; zinc ion binding" IPR001164; IPR011993; IPR001849; Arf-GAP with dual PH domain-containing protein 1 (Centaurin-alpha-1) (Cnt-a1) (Putative MAPK-activating protein PM25) ADAP1 CENTA1 Homo sapiens (Human) TR34235_c0_g3_i4 Q5ZK62 ACAP2_CHICK 1.00E-21 GO:0008060; GO:1990090; GO:0010008; GO:0005543; GO:0043547; GO:0036010; GO:0032312; GO:0008270 ARF GTPase activator activity; cellular response to nerve growth factor stimulus; endosome membrane; phospholipid binding; positive regulation of GTPase activity; protein localization to endosome; regulation of ARF GTPase activity; zinc ion binding IPR027267; IPR002110; IPR020683; IPR001164; IPR011993; IPR001849; "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2)" ACAP2 CENTB2 RCJMB04_12p24 Gallus gallus (Chicken) TR34235_c0_g3_i5 O75689 ADAP1_HUMAN 1.00E-86 GO:0008060; GO:0007166; GO:0005737; GO:0043533; GO:0005634; GO:0005543; GO:0005886; GO:0032312; GO:0008270 "ARF GTPase activator activity; cell surface receptor signaling pathway; cytoplasm; inositol 1,3,4,5 tetrakisphosphate binding; nucleus; phospholipid binding; plasma membrane; regulation of ARF GTPase activity; zinc ion binding" IPR001164; IPR011993; IPR001849; Arf-GAP with dual PH domain-containing protein 1 (Centaurin-alpha-1) (Cnt-a1) (Putative MAPK-activating protein PM25) ADAP1 CENTA1 Homo sapiens (Human) TR34236_c0_g1_i2 Q5MYU0 OAS2_RAT 4.00E-27 GO:0001730; GO:0005524; GO:0051607; GO:0003725; GO:0005783; GO:0045087; GO:0046872; GO:0005739; GO:0005634; GO:0048471; GO:0006486; GO:0018377; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; defense response to virus; double-stranded RNA binding; endoplasmic reticulum; innate immune response; metal ion binding; mitochondrion; nucleus; perinuclear region of cytoplasm; protein glycosylation; protein myristoylation; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) Oas2 Rattus norvegicus (Rat) TR34236_c0_g1_i3 Q9Y6K5 OAS3_HUMAN 6.00E-29 GO:0001730; GO:0005524; GO:0005829; GO:0051607; GO:0003725; GO:0060333; GO:0043231; GO:0046872; GO:0045071; GO:0006139; GO:0005634; GO:0060700; GO:0060337 Q7L2E3; P56537; Q8IY81; Q12894; Q7Z434 2'-5'-oligoadenylate synthetase activity; ATP binding; cytosol; defense response to virus; double-stranded RNA binding; interferon-gamma-mediated signaling pathway; intracellular membrane-bounded organelle; metal ion binding; negative regulation of viral genome replication; nucleobase-containing compound metabolic process; nucleus; regulation of ribonuclease activity; type I interferon-mediated signaling pathway IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (p100 OAS) (p100OAS) OAS3 P/OKcl.4 Homo sapiens (Human) TR34236_c0_g1_i5 Q5MYT9 OASL2_RAT 4.00E-22 GO:0001730; GO:0005524; GO:0051607; GO:0003725; GO:0045087; GO:0046872; GO:0006164; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; defense response to virus; double-stranded RNA binding; innate immune response; metal ion binding; purine nucleotide biosynthetic process; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR022617; IPR000626; 2'-5'-oligoadenylate synthase-like protein 2 (EC 2.7.7.84) Oasl2 Rattus norvegicus (Rat) TR34236_c0_g1_i6 Q9Y6K5 OAS3_HUMAN 1.00E-31 GO:0001730; GO:0005524; GO:0005829; GO:0051607; GO:0003725; GO:0060333; GO:0043231; GO:0046872; GO:0045071; GO:0006139; GO:0005634; GO:0060700; GO:0060337 Q7L2E3; P56537; Q8IY81; Q12894; Q7Z434 2'-5'-oligoadenylate synthetase activity; ATP binding; cytosol; defense response to virus; double-stranded RNA binding; interferon-gamma-mediated signaling pathway; intracellular membrane-bounded organelle; metal ion binding; negative regulation of viral genome replication; nucleobase-containing compound metabolic process; nucleus; regulation of ribonuclease activity; type I interferon-mediated signaling pathway IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (p100 OAS) (p100OAS) OAS3 P/OKcl.4 Homo sapiens (Human) TR34236_c0_g1_i7 Q5MYU0 OAS2_RAT 3.00E-27 GO:0001730; GO:0005524; GO:0051607; GO:0003725; GO:0005783; GO:0045087; GO:0046872; GO:0005739; GO:0005634; GO:0048471; GO:0006486; GO:0018377; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; defense response to virus; double-stranded RNA binding; endoplasmic reticulum; innate immune response; metal ion binding; mitochondrion; nucleus; perinuclear region of cytoplasm; protein glycosylation; protein myristoylation; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) Oas2 Rattus norvegicus (Rat) TR34236_c0_g1_i8 Q8VI94 OASL1_MOUSE 6.00E-21 GO:0005524; GO:0003677; GO:0005737; GO:0051607; GO:0003725; GO:0045087; GO:0045071; GO:0005730; GO:0009615; GO:0016740 ATP binding; DNA binding; cytoplasm; defense response to virus; double-stranded RNA binding; innate immune response; negative regulation of viral genome replication; nucleolus; response to virus; transferase activity IPR006117; IPR006116; IPR018952; IPR026774; IPR000626; "2'-5'-oligoadenylate synthase-like protein 1 (2',5'-oligoadenylate synthetase-like 9)" Oasl1 oasl9 Mus musculus (Mouse) TR34236_c0_g5_i1 Q9Y6K5 OAS3_HUMAN 4.00E-31 GO:0001730; GO:0005524; GO:0005829; GO:0051607; GO:0003725; GO:0060333; GO:0043231; GO:0046872; GO:0045071; GO:0006139; GO:0005634; GO:0060700; GO:0060337 Q7L2E3; P56537; Q8IY81; Q12894; Q7Z434 2'-5'-oligoadenylate synthetase activity; ATP binding; cytosol; defense response to virus; double-stranded RNA binding; interferon-gamma-mediated signaling pathway; intracellular membrane-bounded organelle; metal ion binding; negative regulation of viral genome replication; nucleobase-containing compound metabolic process; nucleus; regulation of ribonuclease activity; type I interferon-mediated signaling pathway IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (p100 OAS) (p100OAS) OAS3 P/OKcl.4 Homo sapiens (Human) TR34236_c0_g5_i2 Q8VI94 OASL1_MOUSE 4.00E-20 GO:0005524; GO:0003677; GO:0005737; GO:0051607; GO:0003725; GO:0045087; GO:0045071; GO:0005730; GO:0009615; GO:0016740 ATP binding; DNA binding; cytoplasm; defense response to virus; double-stranded RNA binding; innate immune response; negative regulation of viral genome replication; nucleolus; response to virus; transferase activity IPR006117; IPR006116; IPR018952; IPR026774; IPR000626; "2'-5'-oligoadenylate synthase-like protein 1 (2',5'-oligoadenylate synthetase-like 9)" Oasl1 oasl9 Mus musculus (Mouse) TR34236_c0_g5_i4 Q5MYT9 OASL2_RAT 6.00E-23 GO:0001730; GO:0005524; GO:0051607; GO:0003725; GO:0045087; GO:0046872; GO:0006164; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; defense response to virus; double-stranded RNA binding; innate immune response; metal ion binding; purine nucleotide biosynthetic process; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR022617; IPR000626; 2'-5'-oligoadenylate synthase-like protein 2 (EC 2.7.7.84) Oasl2 Rattus norvegicus (Rat) TR34236_c0_g5_i5 Q9Z2F2 OASL2_MOUSE 1.00E-21 GO:0001730; GO:0005524; GO:0051607; GO:0003725; GO:0045087; GO:0046872; GO:0006164; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; defense response to virus; double-stranded RNA binding; innate immune response; metal ion binding; purine nucleotide biosynthetic process; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR000626; 2'-5'-oligoadenylate synthase-like protein 2 (EC 2.7.7.84) (54 kDa 2'-5'-oligoadenylate synthase-like protein) (p54 OASL) (M1204) Oasl2 Mus musculus (Mouse) TR34236_c0_g5_i6 F1N3B8 OAS2_BOVIN 1.00E-27 GO:0001730; GO:0005524; GO:0006401; GO:0051607; GO:0003725; GO:0005783; GO:0045087; GO:0005739; GO:0005634; GO:0048471; GO:0006486; GO:0018377; GO:0006164; GO:0009615; GO:0008270 2'-5'-oligoadenylate synthetase activity; ATP binding; RNA catabolic process; defense response to virus; double-stranded RNA binding; endoplasmic reticulum; innate immune response; mitochondrion; nucleus; perinuclear region of cytoplasm; protein glycosylation; protein myristoylation; purine nucleotide biosynthetic process; response to virus; zinc ion binding IPR006117; IPR006116; IPR018952; IPR026774; 2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) OAS2 Bos taurus (Bovine) TR34238_c1_g1_i1 A7X3Z7 LEC2_LIOPO 8.00E-10 GO:0030246; GO:0005576; GO:0046872 carbohydrate binding; extracellular region; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; C-type lectin lectoxin-Lio2 (CTL) Liophis poecilogyrus (Water snake) TR34239_c0_g1_i2 Q64611 CSAD_RAT 6.00E-174 GO:0019752; GO:0005829; GO:0030170; GO:0004782; GO:0042412 carboxylic acid metabolic process; cytosol; pyridoxal phosphate binding; sulfinoalanine decarboxylase activity; taurine biosynthetic process IPR002129; IPR015424; IPR015421; IPR015422; IPR021115; Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 2/2. Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase) Csad Csd Rattus norvegicus (Rat) TR34239_c0_g1_i3 A6QM00 GADL1_BOVIN 6.00E-162 GO:0016831; GO:0019752; GO:0030170 carboxy-lyase activity; carboxylic acid metabolic process; pyridoxal phosphate binding IPR002129; IPR015424; IPR015421; IPR015422; IPR021115; Glutamate decarboxylase-like protein 1 (EC 4.1.1.-) GADL1 Bos taurus (Bovine) TR34240_c0_g1_i2 A2BE28 LAS1L_MOUSE 2.00E-20 GO:0071339; GO:0005737; GO:0005730; GO:0006364 MLL1 complex; cytoplasm; nucleolus; rRNA processing IPR007174; Ribosomal biogenesis protein LAS1L (Protein LAS1 homolog) Las1l Mus musculus (Mouse) TR34240_c1_g1_i1 Q9Y5Q8 TF3C5_HUMAN 6.00E-79 GO:0042791; GO:0003677; GO:0005654; GO:0035914; GO:0042797; GO:0000127 5S class rRNA transcription from RNA polymerase III type 1 promoter; DNA binding; nucleoplasm; skeletal muscle cell differentiation; tRNA transcription from RNA polymerase III promoter; transcription factor TFIIIC complex IPR019136; General transcription factor 3C polypeptide 5 (TF3C-epsilon) (Transcription factor IIIC 63 kDa subunit) (TFIIIC 63 kDa subunit) (TFIIIC63) (Transcription factor IIIC subunit epsilon) GTF3C5 CDABP0017 Homo sapiens (Human) TR34241_c2_g3_i1 P83095 LACTB_BOVIN 4.00E-53 GO:0016787; GO:0005739 hydrolase activity; mitochondrion IPR001466; IPR012338; "Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-)" LACTB Bos taurus (Bovine) TR34241_c2_g3_i2 P83095 LACTB_BOVIN 5.00E-52 GO:0016787; GO:0005739 hydrolase activity; mitochondrion IPR001466; IPR012338; "Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-)" LACTB Bos taurus (Bovine) TR34241_c2_g4_i1 Q5FRJ7 DAP_GLUOX 4.00E-07 GO:0004177; GO:0006508 aminopeptidase activity; proteolysis IPR001466; IPR012338; IPR027279; IPR009090; IPR023645; IPR012857; D-aminopeptidase (EC 3.4.11.19) dap GOX1238 Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans) TR34243_c1_g2_i3 P15206 CCNB_MARGL 4.00E-41 GO:0051301; GO:0007067; GO:0005634; GO:0000079 cell division; mitosis; nucleus; regulation of cyclin-dependent protein serine/threonine kinase activity IPR013763; IPR014400; IPR004367; IPR006671; G2/mitotic-specific cyclin-B Marthasterias glacialis (Spiny starfish) TR34244_c0_g1_i1 Q7ZV00 OTU6B_DANRE 5.00E-71 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR003323; OTU domain-containing protein 6B (EC 3.4.19.12) otud6b zgc:56305 Danio rerio (Zebrafish) (Brachydanio rerio) TR34245_c0_g2_i1 Q5THJ4 VP13D_HUMAN 3.00E-67 IPR009060; IPR015940; IPR000449; IPR026847; IPR026854; IPR009543; Vacuolar protein sorting-associated protein 13D VPS13D KIAA0453 Homo sapiens (Human) TR34245_c0_g4_i1 Q5THJ4 VP13D_HUMAN 0 IPR009060; IPR015940; IPR000449; IPR026847; IPR026854; IPR009543; Vacuolar protein sorting-associated protein 13D VPS13D KIAA0453 Homo sapiens (Human) TR34246_c0_g1_i1 P12111 CO6A3_HUMAN 1.00E-16 GO:0007411; GO:0007155; GO:0030574; GO:0005589; GO:0005788; GO:0022617; GO:0005615; GO:0007517; GO:0042383; GO:0004867 axon guidance; cell adhesion; collagen catabolic process; collagen type VI; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular space; muscle organ development; sarcolemma; serine-type endopeptidase inhibitor activity IPR008160; IPR003961; IPR013783; IPR002223; IPR020901; IPR002035; Collagen alpha-3(VI) chain COL6A3 Homo sapiens (Human) TR34246_c0_g1_i2 A6H584 CO6A5_MOUSE 7.00E-10 GO:0007155; GO:0005581; GO:0005576 cell adhesion; collagen; extracellular region IPR008160; IPR002035; Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) Col6a5 Col29a1 Gm7455 Mus musculus (Mouse) TR34249_c3_g1_i1 Q8UWD8 GDF8_COLLI 8.00E-31 GO:0005615; GO:0040007 extracellular space; growth IPR015616; IPR001839; IPR001111; IPR015615; IPR017948; Growth/differentiation factor 8 (GDF-8) (Myostatin) MSTN GDF8 Columba livia (Domestic pigeon) TR3425_c0_g1_i1 Q5XK85 K0556_XENLA 8.00E-08 IPR027859; IPR026704; Uncharacterized protein KIAA0556 homolog Xenopus laevis (African clawed frog) TR34250_c1_g1_i5 Q8WVC0 LEO1_HUMAN 7.00E-80 GO:0016593; GO:0016055; GO:0001711; GO:0033523; GO:0010390; GO:0006378; GO:0045638; GO:0005730; GO:0031442; GO:0032968; GO:0045944; GO:0019827; GO:0006351 Q6P1J9; P35222; Q8N7H5; P23193 "Cdc73/Paf1 complex; Wnt receptor signaling pathway; endodermal cell fate commitment; histone H2B ubiquitination; histone monoubiquitination; mRNA polyadenylation; negative regulation of myeloid cell differentiation; nucleolus; positive regulation of mRNA 3'-end processing; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; stem cell maintenance; transcription, DNA-dependent" IPR007149; RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) LEO1 RDL Homo sapiens (Human) TR34250_c1_g1_i6 Q52KV5 LEO1_XENLA 6.00E-80 GO:0016593; GO:0032968; GO:0045944; GO:0006351 "Cdc73/Paf1 complex; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR007149; RNA polymerase-associated protein LEO1 leo1 Xenopus laevis (African clawed frog) TR34251_c0_g1_i2 P42297 YXIE_BACSU 1.00E-09 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein YxiE (USP YxiE) yxiE BSU39250 N17E Bacillus subtilis (strain 168) TR34252_c2_g2_i6 Q5I0H4 TMCO1_RAT 3.00E-72 GO:0000139; GO:0005789; GO:0016021 Golgi membrane; endoplasmic reticulum membrane; integral to membrane IPR002809; IPR008559; Transmembrane and coiled-coil domains protein 1 (Meg-2-like protein) Tmco1 Rattus norvegicus (Rat) TR34254_c0_g1_i1 Q9UM13 APC10_HUMAN 1.00E-77 GO:0000086; GO:0005680; GO:0031145; GO:0051301; GO:0005829; GO:0007067; GO:0000090; GO:0007094; GO:0051436; GO:0005654; GO:0051437; GO:0070979; GO:0004842 G2/M transition of mitotic cell cycle; anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; cytosol; mitosis; mitotic anaphase; mitotic spindle assembly checkpoint; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; protein K11-linked ubiquitination; ubiquitin-protein ligase activity IPR016901; IPR004939; IPR008979; Protein modification; protein ubiquitination. Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10) ANAPC10 APC10 Homo sapiens (Human) TR34255_c1_g1_i1 Q8CDF7 EXD1_MOUSE 3.00E-46 GO:0008408; GO:0003676; GO:0090305 3'-5' exonuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis IPR002562; IPR012337; Exonuclease 3'-5' domain-containing protein 1 (Exonuclease 3'-5' domain-like-containing protein 1) Exd1 Exdl1 Mus musculus (Mouse) TR34256_c0_g1_i2 Q62634 VGLU1_RAT 6.00E-81 GO:0051938; GO:0030054; GO:0060076; GO:0005315; GO:0016021; GO:0043229; GO:0007616; GO:0043005; GO:0006836; GO:0048786; GO:0060079; GO:0042137; GO:0015321; GO:0015319; GO:0035249; GO:0030672 "L-glutamate import; cell junction; excitatory synapse; inorganic phosphate transmembrane transporter activity; integral to membrane; intracellular organelle; long-term memory; neuron projection; neurotransmitter transport; presynaptic active zone; regulation of excitatory postsynaptic membrane potential; sequestering of neurotransmitter; sodium-dependent phosphate transmembrane transporter activity; sodium:inorganic phosphate symporter activity; synaptic transmission, glutamatergic; synaptic vesicle membrane" IPR011701; IPR020846; IPR016196; Vesicular glutamate transporter 1 (VGluT1) (Brain-specific Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 7) Slc17a7 Bnpi Vglut1 Rattus norvegicus (Rat) TR34256_c0_g1_i3 Q8NDX2 VGLU3_HUMAN 6.00E-85 GO:0005313; GO:0030054; GO:0016021; GO:0006811; GO:0043005; GO:0006836; GO:0007605; GO:0006814; GO:0015293; GO:0030672; GO:0055085 L-glutamate transmembrane transporter activity; cell junction; integral to membrane; ion transport; neuron projection; neurotransmitter transport; sensory perception of sound; sodium ion transport; symporter activity; synaptic vesicle membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8) SLC17A8 VGLUT3 Homo sapiens (Human) TR34257_c2_g4_i1 Q2TBF2 WSCD2_HUMAN 6.00E-09 GO:0016021 integral to membrane IPR027417; IPR002889; IPR013994; WSC domain-containing protein 2 WSCD2 KIAA0789 Homo sapiens (Human) TR34257_c2_g4_i5 P84675 PFM_CHAGB 2.00E-08 GO:0050832; GO:0031640 defense response to fungus; killing of cells of other organism IPR002889; IPR013994; Putative fungistatic metabolite CHGG_05463 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) TR34257_c2_g5_i1 A2BGL3 WSCD2_DANRE 5.00E-10 GO:0016021; GO:0008146 integral to membrane; sulfotransferase activity IPR027417; IPR000863; IPR002889; IPR013994; WSC domain-containing protein 2 wscd2 si:ch211-240b21.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR34259_c0_g1_i1 Q54UQ4 RBSK_DICDI 7.00E-47 GO:0005524; GO:0019303; GO:0004747 ATP binding; D-ribose catabolic process; ribokinase activity IPR011611; IPR002139; Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2. Probable ribokinase (EC 2.7.1.15) rbsk DDB_G0280893 Dictyostelium discoideum (Slime mold) TR34259_c0_g1_i2 Q9H477 RBSK_HUMAN 1.00E-97 GO:0005524; GO:0019303; GO:0004747 ATP binding; D-ribose catabolic process; ribokinase activity IPR002173; IPR011877; IPR011611; IPR002139; Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2. Ribokinase (EC 2.7.1.15) RBKS RBSK Homo sapiens (Human) TR3426_c0_g1_i1 Q90593 GRP78_CHICK 6.00E-38 GO:0005524; GO:0008180; GO:0006983; GO:0006987; GO:0009986; GO:0042149; GO:0071353; GO:0021680; GO:0021589; GO:0034663; GO:0005788; GO:0005793; GO:0030176; GO:0030496; GO:0043066; GO:0030512; GO:0031398; GO:0051603; GO:0043022 Q8AYS8 ATP binding; COP9 signalosome; ER overload response; activation of signaling protein activity involved in unfolded protein response; cell surface; cellular response to glucose starvation; cellular response to interleukin-4; cerebellar Purkinje cell layer development; cerebellum structural organization; endoplasmic reticulum chaperone complex; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment; integral to endoplasmic reticulum membrane; midbody; negative regulation of apoptotic process; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of protein ubiquitination; proteolysis involved in cellular protein catabolic process; ribosome binding IPR018181; IPR013126; 78 kDa glucose-regulated protein (GRP-78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP) HSPA5 GRP78 Gallus gallus (Chicken) TR34261_c1_g2_i1 Q6H849 NRL4_ORYSJ 1.00E-07 GO:0047427; GO:0006807 cyanoalanine nitrilase activity; nitrogen compound metabolic process IPR003010; IPR000132; Bifunctional nitrilase/nitrile hydratase NIT4 (OsNIT4) (EC 3.5.5.1) (EC 3.5.5.4) (Cyanoalanine nitrilase) (Nitrilase 4) NIT4 Os02g0635200 LOC_Os02g42350 OJ1626_B09.8 OsJ_007404 Oryza sativa subsp. japonica (Rice) TR34261_c1_g2_i2 Q28IE5 NIT2_XENTR 4.00E-126 GO:0005737; GO:0006807; GO:0050152 cytoplasm; nitrogen compound metabolic process; omega-amidase activity IPR003010; Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2) nit2 TNeu073c04.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34261_c1_g2_i5 Q28IE5 NIT2_XENTR 3.00E-127 GO:0005737; GO:0006807; GO:0050152 cytoplasm; nitrogen compound metabolic process; omega-amidase activity IPR003010; Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2) nit2 TNeu073c04.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34262_c5_g1_i1 F8W2M1 HACE1_DANRE 2.00E-15 GO:0032580; GO:0000139; GO:0007030; GO:0017137; GO:0007049; GO:0005783; GO:0061025; GO:0070936; GO:0042787; GO:0030334; GO:0004842 Golgi cisterna membrane; Golgi membrane; Golgi organization; Rab GTPase binding; cell cycle; endoplasmic reticulum; membrane fusion; protein K48-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of cell migration; ubiquitin-protein ligase activity IPR002110; IPR020683; IPR000569; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HACE1 (EC 6.3.2.-) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) hace1 Danio rerio (Zebrafish) (Brachydanio rerio) TR34262_c6_g1_i1 Q3EC11 ZDHC2_ARATH 2.00E-24 GO:0005794; GO:0000139; GO:0016021; GO:0016746; GO:0008270 "Golgi apparatus; Golgi membrane; integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR002110; IPR020683; IPR001594; Probable protein S-acyltransferase 23 (EC 2.3.1.225) (Probable palmitoyltransferase At2g14255) (Zinc finger DHHC domain-containing protein At2g14255) PAT23 At2g14255 T1O16.20 Arabidopsis thaliana (Mouse-ear cress) TR34262_c6_g1_i2 Q99NH0 ANR17_MOUSE 3.00E-18 GO:0003723; GO:0001955; GO:0005737; GO:0007492; GO:0051151; GO:0005634 RNA binding; blood vessel maturation; cytoplasm; endoderm development; negative regulation of smooth muscle cell differentiation; nucleus IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) TR34262_c6_g1_i3 Q554E7 ZDHC5_DICDI 1.00E-26 GO:0016021; GO:0016746; GO:0008270 "integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR002110; IPR020683; IPR001594; Putative ZDHHC-type palmitoyltransferase 5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) DDB_G0275097 Dictyostelium discoideum (Slime mold) TR34262_c6_g1_i4 Q6GNY1 MIB1_XENLA 1.00E-13 GO:0007219; GO:0005737; GO:0004842; GO:0008270 Notch signaling pathway; cytoplasm; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase mib1 (EC 6.3.2.-) (Mind bomb homolog 1) mib1 Xenopus laevis (African clawed frog) TR34262_c6_g1_i5 O89019 INVS_MOUSE 6.00E-18 GO:0016055; GO:0060971; GO:0001822; GO:0016020; GO:0005874; GO:0090090; GO:0005634; GO:0031016; GO:0048471; GO:0009791; GO:0005819 Q8BP00; Q91ZR4 Wnt receptor signaling pathway; embryonic heart tube left/right pattern formation; kidney development; membrane; microtubule; negative regulation of canonical Wnt receptor signaling pathway; nucleus; pancreas development; perinuclear region of cytoplasm; post-embryonic development; spindle IPR002110; IPR020683; IPR000048; Inversin (Inversion of embryo turning protein) (Nephrocystin-2) Invs Inv Nphp2 Mus musculus (Mouse) TR34263_c0_g1_i1 P24014 SLIT_DROME 2.00E-07 GO:0035385; GO:0071666; GO:0016199; GO:0005509; GO:0048813; GO:0007502; GO:0035050; GO:0007427; GO:0008347; GO:0008406; GO:0008201; GO:0050929; GO:0046331; GO:0008078; GO:0001764; GO:0003151; GO:0005886; GO:0022409; GO:0005578; GO:2000274; GO:0007432 "Roundabout signaling pathway; Slit-Robo signaling complex; axon midline choice point recognition; calcium ion binding; dendrite morphogenesis; digestive tract mesoderm development; embryonic heart tube development; epithelial cell migration, open tracheal system; glial cell migration; gonad development; heparin binding; induction of negative chemotaxis; lateral inhibition; mesodermal cell migration; neuron migration; outflow tract morphogenesis; plasma membrane; positive regulation of cell-cell adhesion; proteinaceous extracellular matrix; regulation of epithelial cell migration, open tracheal system; salivary gland boundary specification" IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; IPR026906; Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) TR34263_c0_g1_i2 B3A0S3 ELDP2_LOTGI 5.00E-16 GO:0005576 extracellular region IPR000742; IPR013032; IPR001507; EGF-like domain-containing protein 2 (Uncharacterized shell protein 24) (LUSP-24) Lottia gigantea (Giant owl limpet) TR34265_c4_g1_i1 Q05654 RTF21_SCHPO 1.00E-10 TR34268_c6_g1_i2 Q8Q0U0 Y045_METMA 3.00E-06 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR34268_c6_g1_i4 Q8Q0U0 Y045_METMA 3.00E-06 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR34268_c8_g1_i11 Q96AX9 MIB2_HUMAN 6.00E-07 GO:0007219; GO:0005768; GO:0043123; GO:0004871; GO:0004842; GO:0008270 Q9UHD2 Notch signaling pathway; endosome; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1) MIB2 SKD ZZANK1 Homo sapiens (Human) TR34268_c8_g1_i3 Q80YE7 DAPK1_MOUSE 8.00E-12 GO:0005524; GO:0015629; GO:0005516; GO:0004683; GO:0071346; GO:0005829; GO:0008625; GO:0007243; GO:0043066; GO:1902042; GO:0017148; GO:0046777; GO:0004672; GO:2000310 Q01097 ATP binding; actin cytoskeleton; calmodulin binding; calmodulin-dependent protein kinase activity; cellular response to interferon-gamma; cytosol; extrinsic apoptotic signaling pathway via death domain receptors; intracellular protein kinase cascade; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of translation; protein autophosphorylation; protein kinase activity; regulation of N-methyl-D-aspartate selective glutamate receptor activity IPR002110; IPR020683; IPR011029; IPR000488; IPR011009; IPR020675; IPR027417; IPR000719; IPR017441; IPR002290; IPR008271; Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) Dapk1 Mus musculus (Mouse) TR34271_c0_g1_i1 P81547 AXP1_ANTAF 2.00E-16 GO:0005576; GO:0042151; GO:0004867 extracellular region; nematocyst; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Kunitz-type proteinase inhibitor AXPI-I Anthopleura aff. xanthogrammica (Sea anemone) TR34271_c0_g1_i2 P86862 APKT1_ANTEL 3.00E-15 GO:0019870; GO:0004867 potassium channel inhibitor activity; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Toxin APEKTx1 Anthopleura elegantissima (Sea anemone) TR34271_c0_g1_i3 P81547 AXP1_ANTAF 1.00E-16 GO:0005576; GO:0042151; GO:0004867 extracellular region; nematocyst; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Kunitz-type proteinase inhibitor AXPI-I Anthopleura aff. xanthogrammica (Sea anemone) TR34271_c0_g1_i4 B5L5M7 IVBI_AUSSU 1.00E-13 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Kunitz/BPTI-like toxin Austrelaps superbus (Lowland copperhead snake) (Hoplocephalus superbus) TR34271_c0_g1_i5 P86862 APKT1_ANTEL 2.00E-14 GO:0019870; GO:0004867 potassium channel inhibitor activity; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Toxin APEKTx1 Anthopleura elegantissima (Sea anemone) TR34272_c0_g1_i4 Q12996 CSTF3_HUMAN 9.00E-24 GO:0003723; GO:0006379; GO:0006378; GO:0000398; GO:0005654; GO:0006369 "RNA binding; mRNA cleavage; mRNA polyadenylation; mRNA splicing, via spliceosome; nucleoplasm; termination of RNA polymerase II transcription" IPR003107; IPR008847; Cleavage stimulation factor subunit 3 (CF-1 77 kDa subunit) (Cleavage stimulation factor 77 kDa subunit) (CSTF 77 kDa subunit) (CstF-77) CSTF3 Homo sapiens (Human) TR34276_c0_g1_i1 Q96MP8 KCTD7_HUMAN 2.00E-14 GO:0008219; GO:0005829; GO:0005886; GO:0051260 cell death; cytosol; plasma membrane; protein homooligomerization IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein KCTD7 KCTD7 Homo sapiens (Human) TR34277_c0_g1_i1 O15990 KARG_LIOJA 2.00E-170 GO:0005524; GO:0004054 ATP binding; arginine kinase activity IPR022415; IPR022414; IPR022413; IPR014746; Arginine kinase (AK) (EC 2.7.3.3) Liolophura japonica (Chiton) (Acanthopleura japonica) TR34279_c1_g1_i1 Q96JB2 COG3_HUMAN 0 GO:0006888; GO:0032580; GO:0017119; GO:0005801; GO:0006891; GO:0006886; GO:0005634; GO:0005886; GO:0006486; GO:0033365; GO:0050821; GO:0008565; GO:0006890 "ER to Golgi vesicle-mediated transport; Golgi cisterna membrane; Golgi transport complex; cis-Golgi network; intra-Golgi vesicle-mediated transport; intracellular protein transport; nucleus; plasma membrane; protein glycosylation; protein localization to organelle; protein stabilization; protein transporter activity; retrograde vesicle-mediated transport, Golgi to ER" IPR007265; Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) COG3 SEC34 Homo sapiens (Human) TR34279_c1_g1_i2 Q96JB2 COG3_HUMAN 0 GO:0006888; GO:0032580; GO:0017119; GO:0005801; GO:0006891; GO:0006886; GO:0005634; GO:0005886; GO:0006486; GO:0033365; GO:0050821; GO:0008565; GO:0006890 "ER to Golgi vesicle-mediated transport; Golgi cisterna membrane; Golgi transport complex; cis-Golgi network; intra-Golgi vesicle-mediated transport; intracellular protein transport; nucleus; plasma membrane; protein glycosylation; protein localization to organelle; protein stabilization; protein transporter activity; retrograde vesicle-mediated transport, Golgi to ER" IPR007265; Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) COG3 SEC34 Homo sapiens (Human) TR34280_c1_g3_i1 Q15119 PDK2_HUMAN 2.00E-114 GO:0005524; GO:0031670; GO:0034614; GO:0042593; GO:0006006; GO:0008286; GO:0072332; GO:0005967; GO:0005634; GO:0004674; GO:0004740; GO:0006090; GO:0010510; GO:0006111; GO:0006885 ATP binding; cellular response to nutrient; cellular response to reactive oxygen species; glucose homeostasis; glucose metabolic process; insulin receptor signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; mitochondrial pyruvate dehydrogenase complex; nucleus; protein serine/threonine kinase activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; pyruvate metabolic process; regulation of acetyl-CoA biosynthetic process from pyruvate; regulation of gluconeogenesis; regulation of pH IPR018955; IPR003594; IPR005467; "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)" PDK2 PDHK2 Homo sapiens (Human) TR34280_c1_g3_i4 Q15120 PDK3_HUMAN 9.00E-113 GO:0005524; GO:0071398; GO:0071333; GO:0006006; GO:0097411; GO:0005759; GO:0018105; GO:0035357; GO:0004674; GO:0004740; GO:0006090; GO:0010510; GO:0010906; GO:2000377 ATP binding; cellular response to fatty acid; cellular response to glucose stimulus; glucose metabolic process; hypoxia-inducible factor-1alpha signaling pathway; mitochondrial matrix; peptidyl-serine phosphorylation; peroxisome proliferator activated receptor signaling pathway; protein serine/threonine kinase activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; pyruvate metabolic process; regulation of acetyl-CoA biosynthetic process from pyruvate; regulation of glucose metabolic process; regulation of reactive oxygen species metabolic process IPR018955; IPR003594; IPR005467; "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)" PDK3 PDHK3 Homo sapiens (Human) TR34281_c1_g1_i1 O75094 SLIT3_HUMAN 5.00E-09 GO:0035385; GO:0061364; GO:0048846; GO:0005509; GO:0032870; GO:0005615; GO:0005739; GO:0050919; GO:0030308; GO:0008285; GO:0070100; GO:0010629; GO:0009887; GO:0051414 Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; calcium ion binding; cellular response to hormone stimulus; extracellular space; mitochondrion; negative chemotaxis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of chemokine-mediated signaling pathway; negative regulation of gene expression; organ morphogenesis; response to cortisol stimulus IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 3 protein (Slit-3) (Multiple epidermal growth factor-like domains protein 5) (Multiple EGF-like domains protein 5) SLIT3 KIAA0814 MEGF5 SLIL2 UNQ691/PRO1336 Homo sapiens (Human) TR34281_c4_g2_i1 Q9Z2H4 LGR4_RAT 2.00E-07 GO:0007186; GO:0016055; GO:0030282; GO:0046849; GO:0045087; GO:0005887; GO:0050710; GO:0034122; GO:0001649; GO:0090263; GO:0007283; GO:0004888 G-protein coupled receptor signaling pathway; Wnt receptor signaling pathway; bone mineralization; bone remodeling; innate immune response; integral to plasma membrane; negative regulation of cytokine secretion; negative regulation of toll-like receptor signaling pathway; osteoblast differentiation; positive regulation of canonical Wnt receptor signaling pathway; spermatogenesis; transmembrane signaling receptor activity IPR000276; IPR017452; IPR002131; IPR001611; IPR025875; IPR003591; IPR000372; Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48) Lgr4 Gpr48 Rattus norvegicus (Rat) TR34281_c5_g1_i1 Q8K406 LGI3_MOUSE 1.00E-06 GO:0003824; GO:0030054; GO:0006887; GO:0005576; GO:0008152; GO:0043005; GO:0017157; GO:0008021 catalytic activity; cell junction; exocytosis; extracellular region; metabolic process; neuron projection; regulation of exocytosis; synaptic vesicle IPR000483; IPR009039; IPR005492; IPR001611; IPR003591; IPR011041; Leucine-rich repeat LGI family member 3 (Leubrin) (Leucine-rich glioma-inactivated protein 3) Lgi3 Mus musculus (Mouse) TR34281_c5_g2_i1 P13224 GP1BB_HUMAN 3.00E-06 GO:0007597; GO:0007155; GO:0007166; GO:0005887; GO:0030168; GO:0004888 "blood coagulation, intrinsic pathway; cell adhesion; cell surface receptor signaling pathway; integral to plasma membrane; platelet activation; transmembrane signaling receptor activity" IPR000483; IPR000372; Platelet glycoprotein Ib beta chain (GP-Ib beta) (GPIb-beta) (GPIbB) (Antigen CD42b-beta) (CD antigen CD42c) GP1BB Homo sapiens (Human) TR34282_c4_g1_i4 Q4V842 GPTC4_XENLA 1.00E-54 GO:0003676 nucleic acid binding IPR000467; G patch domain-containing protein 4 gpatch4 gpatc4 Xenopus laevis (African clawed frog) TR34283_c0_g1_i1 Q8NHP7 EXD1_HUMAN 3.00E-07 GO:0008408; GO:0003676; GO:0090305 3'-5' exonuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis IPR002562; IPR012337; Exonuclease 3'-5' domain-containing protein 1 (Exonuclease 3'-5' domain-like-containing protein 1) EXD1 EXDL1 Homo sapiens (Human) TR34284_c1_g1_i1 Q8N6G5 CGAT2_HUMAN 2.00E-124 GO:0032580; GO:0008376; GO:0030206; GO:0050653; GO:0050652; GO:0047237; GO:0030173; GO:0046872 "Golgi cisterna membrane; acetylgalactosaminyltransferase activity; chondroitin sulfate biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity; integral to Golgi membrane; metal ion binding" IPR008428; "Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (EC 2.4.1.174) (Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2) (Beta4GalNAcT-2) (GalNAcT-2)" CSGALNACT2 CHGN2 GALNACT2 PRO0082 Homo sapiens (Human) TR34284_c1_g1_i3 Q8N6G5 CGAT2_HUMAN 3.00E-57 GO:0032580; GO:0008376; GO:0030206; GO:0050653; GO:0050652; GO:0047237; GO:0030173; GO:0046872 "Golgi cisterna membrane; acetylgalactosaminyltransferase activity; chondroitin sulfate biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity; integral to Golgi membrane; metal ion binding" IPR008428; "Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (EC 2.4.1.174) (Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2) (Beta4GalNAcT-2) (GalNAcT-2)" CSGALNACT2 CHGN2 GALNACT2 PRO0082 Homo sapiens (Human) TR34288_c0_g2_i2 Q9Y113 NELFB_DROME 1.00E-163 GO:0032021; GO:0003723; GO:0005694; GO:0034244; GO:0007070; GO:0045944; GO:0006351; GO:0017053 "NELF complex; RNA binding; chromosome; negative regulation of transcription elongation from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter during mitosis; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; transcriptional repressor complex" IPR010405; Negative elongation factor B NELF-B CG32721 Drosophila melanogaster (Fruit fly) TR34289_c3_g2_i7 Q8N187 AL2S8_HUMAN 5.00E-08 GO:0003677; GO:0035865; GO:0005730; GO:0005654; GO:0005634; GO:0061400; GO:0003700; GO:0006351 "DNA binding; cellular response to potassium ion; nucleolus; nucleoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter in response to calcium ion; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" Calcium-responsive transcription factor (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) (Calcium-response factor) (CaRF) (Testis development protein NYD-SP24) CARF ALS2CR8 Homo sapiens (Human) TR34290_c7_g2_i1 Q09991 YSS2_CAEEL 5.00E-59 GO:0006508; GO:0004185 proteolysis; serine-type carboxypeptidase activity IPR001563; IPR018202; Uncharacterized serine carboxypeptidase K10B2.2 (EC 3.4.16.-) K10B2.2 Caenorhabditis elegans TR34290_c7_g2_i3 P52717 YUW5_CAEEL 1.00E-58 GO:0006508; GO:0004185 proteolysis; serine-type carboxypeptidase activity IPR001563; IPR018202; Uncharacterized serine carboxypeptidase F41C3.5 (EC 3.4.16.-) F41C3.5 Caenorhabditis elegans TR34290_c7_g3_i2 Q3MI05 PPGB_BOVIN 2.00E-76 GO:0005764; GO:0005634; GO:0006508; GO:0004185 lysosome; nucleus; proteolysis; serine-type carboxypeptidase activity IPR001563; IPR018202; Lysosomal protective protein (EC 3.4.16.5) (Cathepsin A) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain] CTSA PPGB Bos taurus (Bovine) TR34290_c7_g3_i3 Q3MI05 PPGB_BOVIN 3.00E-77 GO:0005764; GO:0005634; GO:0006508; GO:0004185 lysosome; nucleus; proteolysis; serine-type carboxypeptidase activity IPR001563; IPR018202; Lysosomal protective protein (EC 3.4.16.5) (Cathepsin A) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain] CTSA PPGB Bos taurus (Bovine) TR34292_c0_g1_i3 Q6NXH8 MET25_MOUSE 2.00E-38 GO:0008168 methyltransferase activity IPR025714; Methyltransferase-like protein 25 (EC 2.1.1.-) Mettl25 Mus musculus (Mouse) TR34293_c0_g1_i8 P59105 SLEB_OCEIH 2.00E-07 GO:0016787; GO:0008152; GO:0009847; GO:0030435 hydrolase activity; metabolic process; spore germination; sporulation resulting in formation of a cellular spore IPR011105; IPR002477; IPR014224; Spore cortex-lytic enzyme (SCLE) sleB OB1806 Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831) TR34294_c2_g1_i1 A2VD82 TTC38_XENLA 3.00E-112 IPR011990; Tetratricopeptide repeat protein 38 (TPR repeat protein 38) ttc38 Xenopus laevis (African clawed frog) TR34296_c1_g1_i1 Q2PZL6 FAT4_MOUSE 2.00E-12 GO:0045177; GO:0001658; GO:0005509; GO:0048565; GO:0001736; GO:0003007; GO:0007156; GO:0060122; GO:0016021; GO:0001822; GO:0043931; GO:0005886; GO:0007009 apical part of cell; branching involved in ureteric bud morphogenesis; calcium ion binding; digestive tract development; establishment of planar polarity; heart morphogenesis; homophilic cell adhesion; inner ear receptor stereocilium organization; integral to membrane; kidney development; ossification involved in bone maturation; plasma membrane; plasma membrane organization IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) Fat4 Fatj Mus musculus (Mouse) TR34296_c1_g1_i2 Q14517 FAT1_HUMAN 2.00E-15 GO:0007015; GO:0009653; GO:0005509; GO:0016477; GO:0016337; GO:0005911; GO:0007267; GO:0007163; GO:0030175; GO:0007156; GO:0005887; GO:0030027; GO:0005634; GO:0048471 Q8N8S7; Q9NSC5; Q99JP6 actin filament organization; anatomical structure morphogenesis; calcium ion binding; cell migration; cell-cell adhesion; cell-cell junction; cell-cell signaling; establishment or maintenance of cell polarity; filopodium; homophilic cell adhesion; integral to plasma membrane; lamellipodium; nucleus; perinuclear region of cytoplasm IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) TR34298_c3_g1_i1 Q52I78 NAMPT_PIG 8.00E-178 GO:0009435; GO:0005737; GO:0047280; GO:0004514 NAD biosynthetic process; cytoplasm; nicotinamide phosphoribosyltransferase activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity IPR007229; IPR016471; IPR002638; Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1. Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1 homolog) (PBEF) (Visfatin) NAMPT PBEF1 Sus scrofa (Pig) TR34298_c3_g1_i8 P43490 NAMPT_HUMAN 2.00E-178 GO:0009435; GO:0019674; GO:0007267; GO:0005125; GO:0005829; GO:0006769; GO:0047280; GO:0004514; GO:0008284; GO:0051770; GO:0045944; GO:0007165 P02792; Q01628; P03886 NAD biosynthetic process; NAD metabolic process; cell-cell signaling; cytokine activity; cytosol; nicotinamide metabolic process; nicotinamide phosphoribosyltransferase activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity; positive regulation of cell proliferation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; signal transduction IPR007229; IPR016471; IPR002638; Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1. Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) NAMPT PBEF PBEF1 Homo sapiens (Human) TR34298_c5_g1_i1 P97868 RBBP6_MOUSE 8.00E-17 GO:0005694; GO:0005737; GO:0048568; GO:0001701; GO:0005815; GO:0035264; GO:0003676; GO:0005730; GO:0042787; GO:0061053; GO:0004842; GO:0008270 chromosome; cytoplasm; embryonic organ development; in utero embryonic development; microtubule organizing center; multicellular organism growth; nucleic acid binding; nucleolus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; somite development; ubiquitin-protein ligase activity; zinc ion binding IPR014891; IPR001878; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RBBP6 (EC 6.3.2.-) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) Rbbp6 P2pr Pact Mus musculus (Mouse) TR34298_c5_g1_i5 P97868 RBBP6_MOUSE 8.00E-17 GO:0005694; GO:0005737; GO:0048568; GO:0001701; GO:0005815; GO:0035264; GO:0003676; GO:0005730; GO:0042787; GO:0061053; GO:0004842; GO:0008270 chromosome; cytoplasm; embryonic organ development; in utero embryonic development; microtubule organizing center; multicellular organism growth; nucleic acid binding; nucleolus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; somite development; ubiquitin-protein ligase activity; zinc ion binding IPR014891; IPR001878; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RBBP6 (EC 6.3.2.-) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) Rbbp6 P2pr Pact Mus musculus (Mouse) TR34298_c5_g1_i6 P97868 RBBP6_MOUSE 8.00E-17 GO:0005694; GO:0005737; GO:0048568; GO:0001701; GO:0005815; GO:0035264; GO:0003676; GO:0005730; GO:0042787; GO:0061053; GO:0004842; GO:0008270 chromosome; cytoplasm; embryonic organ development; in utero embryonic development; microtubule organizing center; multicellular organism growth; nucleic acid binding; nucleolus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; somite development; ubiquitin-protein ligase activity; zinc ion binding IPR014891; IPR001878; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RBBP6 (EC 6.3.2.-) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) Rbbp6 P2pr Pact Mus musculus (Mouse) TR34299_c0_g1_i1 Q8JIS3 DER_CHICK 1.00E-57 GO:0042732; GO:0050038; GO:0005737; GO:0047880 D-xylose metabolic process; L-xylulose reductase (NADP+) activity; cytoplasm; erythrulose reductase activity IPR002198; IPR002347; IPR016040; IPR020904; D-erythrulose reductase (EC 1.1.1.162) (Probable L-xylulose reductase) (XR) (EC 1.1.1.10) DER Gallus gallus (Chicken) TR34300_c0_g1_i1 Q24292 DS_DROME 9.00E-12 GO:0005509; GO:0016339; GO:0050839; GO:0000904; GO:0008283; GO:0045317; GO:0045198; GO:0001737; GO:0007156; GO:0007480; GO:0005887; GO:0090176; GO:0016318; GO:0018149; GO:0004872; GO:0090175; GO:0035159; GO:0004871; GO:0035222 "calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; cell morphogenesis involved in differentiation; cell proliferation; equator specification; establishment of epithelial cell apical/basal polarity; establishment of imaginal disc-derived wing hair orientation; homophilic cell adhesion; imaginal disc-derived leg morphogenesis; integral to plasma membrane; microtubule cytoskeleton organization involved in establishment of planar polarity; ommatidial rotation; peptide cross-linking; receptor activity; regulation of establishment of planar polarity; regulation of tube length, open tracheal system; signal transducer activity; wing disc pattern formation" IPR002126; IPR015919; IPR020894; IPR000233; Protein dachsous (Adherin) ds CG17941 Drosophila melanogaster (Fruit fly) TR34300_c0_g2_i1 Q08174 PCDH1_HUMAN 1.00E-10 GO:0005509; GO:0005911; GO:0007267; GO:0007156; GO:0005887; GO:0007399 calcium ion binding; cell-cell junction; cell-cell signaling; homophilic cell adhesion; integral to plasma membrane; nervous system development IPR002126; IPR015919; IPR020894; IPR013164; IPR013585; Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) PCDH1 Homo sapiens (Human) TR34300_c2_g1_i1 Q6V0I7 FAT4_HUMAN 3.00E-07 GO:0005509; GO:0007156; GO:0016021; GO:0005886 Q9H2K2 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) TR34302_c3_g1_i1 Q9JKF1 IQGA1_MOUSE 0 GO:0005099; GO:0031252; GO:0071277; GO:0005737; GO:0072015; GO:0016328; GO:0005874; GO:0030496; GO:0035305; GO:0043005; GO:0005634; GO:0032320; GO:0045860; GO:0001817; GO:0030529; GO:0036057; GO:0007264 P03332; P98083 Ras GTPase activator activity; cell leading edge; cellular response to calcium ion; cytoplasm; glomerular visceral epithelial cell development; lateral plasma membrane; microtubule; midbody; negative regulation of dephosphorylation; neuron projection; nucleus; positive regulation of Ras GTPase activity; positive regulation of protein kinase activity; regulation of cytokine production; ribonucleoprotein complex; slit diaphragm; small GTPase mediated signal transduction IPR001715; IPR000048; IPR027401; IPR027417; IPR001936; IPR000593; IPR023152; IPR008936; IPR001202; Ras GTPase-activating-like protein IQGAP1 Iqgap1 Mus musculus (Mouse) TR34302_c4_g1_i10 Q5EA03 TM186_BOVIN 5.00E-24 GO:0016021; GO:0005739 integral to membrane; mitochondrion IPR026571; Transmembrane protein 186 TMEM186 Bos taurus (Bovine) TR34302_c4_g1_i13 P0CF21 SDH1_YEAST 3.00E-06 GO:0003941; GO:0005737; GO:0006094; GO:0030170; GO:0009069 L-serine ammonia-lyase activity; cytoplasm; gluconeogenesis; pyridoxal phosphate binding; serine family amino acid metabolic process IPR000634; IPR001926; Carbohydrate biosynthesis; gluconeogenesis. Truncated L-serine dehydratase (EC 4.3.1.17) (L-serine deaminase) SDL1 SDH1 YIL167W YI9402.08A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR34302_c4_g1_i2 Q8NWQ4 TDCB_STAAW 2.00E-34 GO:0004794; GO:0070689; GO:0000166; GO:0030170 L-threonine ammonia-lyase activity; L-threonine catabolic process to propionate; nucleotide binding; pyridoxal phosphate binding IPR000634; IPR005789; IPR001926; Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine: step 1/4. L-threonine dehydratase catabolic TdcB (EC 4.3.1.19) (Threonine deaminase) tdcB MW1327 Staphylococcus aureus (strain MW2) TR34302_c4_g1_i3 Q5EA03 TM186_BOVIN 5.00E-24 GO:0016021; GO:0005739 integral to membrane; mitochondrion IPR026571; Transmembrane protein 186 TMEM186 Bos taurus (Bovine) TR34302_c4_g1_i5 P46940 IQGA1_HUMAN 1.00E-76 GO:0005096; GO:0005095; GO:0005099; GO:0005884; GO:0005509; GO:0005516; GO:0031252; GO:0071277; GO:0005737; GO:0006112; GO:0072015; GO:0016328; GO:0005874; GO:0030496; GO:0035305; GO:0043005; GO:0005634; GO:0005886; GO:0032320; GO:0045860; GO:0001817; GO:0050796; GO:0030529; GO:0007165; GO:0036057; GO:0007264; GO:0044281 O43707; Q9Y5K6; P60953; P35222; O08808; P00533; P04626; Q96QZ7; O60500; Q9NP85; O00592; Q05823; Q99816 GTPase activator activity; GTPase inhibitor activity; Ras GTPase activator activity; actin filament; calcium ion binding; calmodulin binding; cell leading edge; cellular response to calcium ion; cytoplasm; energy reserve metabolic process; glomerular visceral epithelial cell development; lateral plasma membrane; microtubule; midbody; negative regulation of dephosphorylation; neuron projection; nucleus; plasma membrane; positive regulation of Ras GTPase activity; positive regulation of protein kinase activity; regulation of cytokine production; regulation of insulin secretion; ribonucleoprotein complex; signal transduction; slit diaphragm; small GTPase mediated signal transduction; small molecule metabolic process IPR001715; IPR000048; IPR027401; IPR027417; IPR001936; IPR000593; IPR023152; IPR008936; IPR001202; Ras GTPase-activating-like protein IQGAP1 (p195) IQGAP1 KIAA0051 Homo sapiens (Human) TR34302_c4_g1_i7 Q8NWQ4 TDCB_STAAW 3.00E-34 GO:0004794; GO:0070689; GO:0000166; GO:0030170 L-threonine ammonia-lyase activity; L-threonine catabolic process to propionate; nucleotide binding; pyridoxal phosphate binding IPR000634; IPR005789; IPR001926; Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine: step 1/4. L-threonine dehydratase catabolic TdcB (EC 4.3.1.19) (Threonine deaminase) tdcB MW1327 Staphylococcus aureus (strain MW2) TR34302_c4_g1_i9 P46940 IQGA1_HUMAN 6.00E-57 GO:0005096; GO:0005095; GO:0005099; GO:0005884; GO:0005509; GO:0005516; GO:0031252; GO:0071277; GO:0005737; GO:0006112; GO:0072015; GO:0016328; GO:0005874; GO:0030496; GO:0035305; GO:0043005; GO:0005634; GO:0005886; GO:0032320; GO:0045860; GO:0001817; GO:0050796; GO:0030529; GO:0007165; GO:0036057; GO:0007264; GO:0044281 O43707; Q9Y5K6; P60953; P35222; O08808; P00533; P04626; Q96QZ7; O60500; Q9NP85; O00592; Q05823; Q99816 GTPase activator activity; GTPase inhibitor activity; Ras GTPase activator activity; actin filament; calcium ion binding; calmodulin binding; cell leading edge; cellular response to calcium ion; cytoplasm; energy reserve metabolic process; glomerular visceral epithelial cell development; lateral plasma membrane; microtubule; midbody; negative regulation of dephosphorylation; neuron projection; nucleus; plasma membrane; positive regulation of Ras GTPase activity; positive regulation of protein kinase activity; regulation of cytokine production; regulation of insulin secretion; ribonucleoprotein complex; signal transduction; slit diaphragm; small GTPase mediated signal transduction; small molecule metabolic process IPR001715; IPR000048; IPR027401; IPR027417; IPR001936; IPR000593; IPR023152; IPR008936; IPR001202; Ras GTPase-activating-like protein IQGAP1 (p195) IQGAP1 KIAA0051 Homo sapiens (Human) TR34305_c1_g1_i1 Q19746 INX3_CAEEL 4.00E-56 GO:0005737; GO:0005921; GO:0055077; GO:0016021; GO:0006811; GO:0005886 cytoplasm; gap junction; gap junction hemi-channel activity; integral to membrane; ion transport; plasma membrane IPR000990; Innexin-3 (Protein opu-3) inx-3 opu-3 F22F4.2 Caenorhabditis elegans TR34305_c1_g1_i2 O01393 UNC9_CAEEL 7.00E-70 GO:0005921; GO:0055077; GO:0016021; GO:0034220; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transmembrane transport; plasma membrane IPR000990; Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans TR34305_c1_g1_i3 Q22549 INX10_CAEEL 1.00E-44 GO:0005921; GO:0055077; GO:0016021; GO:0006811; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transport; plasma membrane IPR000990; Innexin-10 (Protein opu-10) inx-10 opu-10 T18H9.5 Caenorhabditis elegans TR34305_c1_g1_i4 Q9XYN0 INX1_SCHAM 3.00E-14 GO:0005921; GO:0005243; GO:0016021; GO:0006811; GO:0005886 gap junction; gap junction channel activity; integral to membrane; ion transport; plasma membrane IPR000990; Innexin inx1 (Innexin-1) (G-Inx1) inx1 Schistocerca americana (American grasshopper) TR34306_c0_g1_i2 P25145 Y432_LISMO 6.00E-60 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Uncharacterized oxidoreductase Lmo0432 (EC 1.-.-.-) (ORFA) lmo0432 Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) TR34310_c0_g1_i2 P13608 PGCA_BOVIN 6.00E-12 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 Q9UNA0; P49747 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Bos taurus (Bovine) TR34310_c0_g3_i1 Q5R7Y0 BAI2_PONAB 1.00E-14 GO:0004930; GO:0016021; GO:0016525; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; negative regulation of angiogenesis; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR008077; IPR001879; IPR000832; IPR000203; IPR000884; Brain-specific angiogenesis inhibitor 2 BAI2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34310_c0_g4_i1 Q19791 GON1_CAEEL 3.00E-06 GO:0006888; GO:0005604; GO:0005623; GO:0016477; GO:0008406; GO:0004222; GO:0008237; GO:0006508; GO:0008270 ER to Golgi vesicle-mediated transport; basement membrane; cell; cell migration; gonad development; metalloendopeptidase activity; metallopeptidase activity; proteolysis; zinc ion binding IPR010294; IPR024079; IPR012314; IPR001590; IPR013273; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs gon-1 (ADAMTS gon-1) (EC 3.4.24.-) (Abnormal gonad development protein 1) gon-1 F25H8.3 Caenorhabditis elegans TR34310_c0_g4_i2 Q3UHD1 BAI1_MOUSE 3.00E-14 GO:0004930; GO:0016021; GO:0016525; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; negative regulation of angiogenesis; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR008077; IPR001879; IPR000832; IPR000203; IPR000884; Brain-specific angiogenesis inhibitor 1 Bai1 Mus musculus (Mouse) TR34313_c2_g1_i1 P48025 KSYK_MOUSE 4.00E-22 GO:0005524; GO:0019815; GO:0050853; GO:0007186; GO:0042101; GO:0007257; GO:0002250; GO:0001525; GO:0043366; GO:0048514; GO:0071226; GO:0005829; GO:0042742; GO:0032009; GO:0007167; GO:0045087; GO:0007229; GO:0007159; GO:0019370; GO:0001945; GO:0002281; GO:0002283; GO:0030593; GO:0004715; GO:0045579; GO:0046638; GO:0046641; GO:0045780; GO:0050850; GO:0033630; GO:0050715; GO:0045588; GO:0045425; GO:0045401; GO:0043306; GO:0050731; GO:0046777; GO:0004716; GO:0070372; GO:0090237; GO:0043313; GO:0050764; GO:0090330; GO:0032928; GO:0002554 P08487; Q64693 ATP binding; B cell receptor complex; B cell receptor signaling pathway; G-protein coupled receptor signaling pathway; T cell receptor complex; activation of JUN kinase activity; adaptive immune response; angiogenesis; beta selection; blood vessel morphogenesis; cellular response to molecule of fungal origin; cytosol; defense response to bacterium; early phagosome; enzyme linked receptor protein signaling pathway; innate immune response; integrin-mediated signaling pathway; leukocyte cell-cell adhesion; leukotriene biosynthetic process; lymph vessel development; macrophage activation involved in immune response; neutrophil activation involved in immune response; neutrophil chemotaxis; non-membrane spanning protein tyrosine kinase activity; positive regulation of B cell differentiation; positive regulation of alpha-beta T cell differentiation; positive regulation of alpha-beta T cell proliferation; positive regulation of bone resorption; positive regulation of calcium-mediated signaling; positive regulation of cell adhesion mediated by integrin; positive regulation of cytokine secretion; positive regulation of gamma-delta T cell differentiation; positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; positive regulation of interleukin-3 biosynthetic process; positive regulation of mast cell degranulation; positive regulation of peptidyl-tyrosine phosphorylation; protein autophosphorylation; receptor signaling protein tyrosine kinase activity; regulation of ERK1 and ERK2 cascade; regulation of arachidonic acid secretion; regulation of neutrophil degranulation; regulation of phagocytosis; regulation of platelet aggregation; regulation of superoxide anion generation; serotonin secretion by platelet IPR011009; IPR023420; IPR000719; IPR017441; IPR001245; IPR000980; IPR008266; IPR020635; IPR012234; Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) Syk ptk72 Sykb Mus musculus (Mouse) TR34313_c5_g1_i1 P43405 KSYK_HUMAN 5.00E-108 GO:0005524; GO:0019815; GO:0050853; GO:0038095; GO:0038096; GO:0042101; GO:0007257; GO:0002250; GO:0001525; GO:0043366; GO:0048514; GO:0008283; GO:0071226; GO:0005829; GO:0042742; GO:0032009; GO:0007167; GO:0045087; GO:0007229; GO:0007159; GO:0019370; GO:0001945; GO:0002281; GO:0019048; GO:0002283; GO:0030593; GO:0004715; GO:0009887; GO:0030168; GO:0045579; GO:0046638; GO:0046641; GO:0045780; GO:0050850; GO:0033630; GO:0050715; GO:0045588; GO:0045425; GO:0045401; GO:0043306; GO:0050731; GO:0046777; GO:0004716; GO:0070372; GO:0090237; GO:0043313; GO:0050764; GO:0090330; GO:0032928; GO:0002554 P22681; P20273; P11049; P07766; P00533; P04626; P21860; P30273; P06239; P19174; Q8TF42 ATP binding; B cell receptor complex; B cell receptor signaling pathway; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; T cell receptor complex; activation of JUN kinase activity; adaptive immune response; angiogenesis; beta selection; blood vessel morphogenesis; cell proliferation; cellular response to molecule of fungal origin; cytosol; defense response to bacterium; early phagosome; enzyme linked receptor protein signaling pathway; innate immune response; integrin-mediated signaling pathway; leukocyte cell-cell adhesion; leukotriene biosynthetic process; lymph vessel development; macrophage activation involved in immune response; modulation by virus of host morphology or physiology; neutrophil activation involved in immune response; neutrophil chemotaxis; non-membrane spanning protein tyrosine kinase activity; organ morphogenesis; platelet activation; positive regulation of B cell differentiation; positive regulation of alpha-beta T cell differentiation; positive regulation of alpha-beta T cell proliferation; positive regulation of bone resorption; positive regulation of calcium-mediated signaling; positive regulation of cell adhesion mediated by integrin; positive regulation of cytokine secretion; positive regulation of gamma-delta T cell differentiation; positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; positive regulation of interleukin-3 biosynthetic process; positive regulation of mast cell degranulation; positive regulation of peptidyl-tyrosine phosphorylation; protein autophosphorylation; receptor signaling protein tyrosine kinase activity; regulation of ERK1 and ERK2 cascade; regulation of arachidonic acid secretion; regulation of neutrophil degranulation; regulation of phagocytosis; regulation of platelet aggregation; regulation of superoxide anion generation; serotonin secretion by platelet IPR011009; IPR023420; IPR000719; IPR017441; IPR001245; IPR000980; IPR008266; IPR020635; IPR012234; Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) SYK Homo sapiens (Human) TR34313_c5_g1_i2 P55245 EGFR_MACMU 6.00E-15 GO:0005524; GO:0000139; GO:0016323; GO:0000902; GO:0008283; GO:0016337; GO:0071392; GO:0021795; GO:0003682; GO:0048546; GO:0001892; GO:0030139; GO:0005789; GO:0005768; GO:0010008; GO:0005006; GO:0001942; GO:0045121; GO:0060571; GO:0043066; GO:0042177; GO:0030235; GO:0031965; GO:0005634; GO:0048471; GO:0045739; GO:0045740; GO:0070374; GO:0043406; GO:0035413; GO:0030335; GO:0031659; GO:0050679; GO:0048146; GO:0045429; GO:0051897; GO:0001934; GO:0045944; GO:0046777; GO:0004713; GO:0050999; GO:0050730; GO:0070141; GO:0007435 ATP binding; Golgi membrane; basolateral plasma membrane; cell morphogenesis; cell proliferation; cell-cell adhesion; cellular response to estradiol stimulus; cerebral cortex cell migration; chromatin binding; digestive tract morphogenesis; embryonic placenta development; endocytic vesicle; endoplasmic reticulum membrane; endosome; endosome membrane; epidermal growth factor-activated receptor activity; hair follicle development; membrane raft; morphogenesis of an epithelial fold; negative regulation of apoptotic process; negative regulation of protein catabolic process; nitric-oxide synthase regulator activity; nuclear membrane; nucleus; perinuclear region of cytoplasm; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAP kinase activity; positive regulation of catenin import into nucleus; positive regulation of cell migration; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of nitric oxide biosynthetic process; positive regulation of protein kinase B signaling cascade; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein autophosphorylation; protein tyrosine kinase activity; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; response to UV-A; salivary gland morphogenesis IPR011009; IPR000719; IPR001245; Epidermal growth factor receptor (EC 2.7.10.1) (Fragment) EGFR Macaca mulatta (Rhesus macaque) TR34314_c2_g1_i3 Q9BRD0 BUD13_HUMAN 1.00E-31 GO:0070274; GO:0006406; GO:0000398 Q92917; Q9Y388 "RES complex; mRNA export from nucleus; mRNA splicing, via spliceosome" IPR018609; BUD13 homolog BUD13 Homo sapiens (Human) TR34314_c2_g3_i2 Q8R149 BUD13_MOUSE 1.00E-11 IPR018609; BUD13 homolog Bud13 Mus musculus (Mouse) TR34315_c0_g8_i2 P62994 GRB2_RAT 2.00E-08 GO:0008180; GO:0005794; GO:0070436; GO:0007265; GO:0017124; GO:0007568; GO:0071479; GO:0005829; GO:0005768; GO:0005154; GO:0008286; GO:2000379; GO:0051291; GO:0031623; GO:0042770 P21575; P35739; P18545; P18031 COP9 signalosome; Golgi apparatus; Grb2-EGFR complex; Ras protein signal transduction; SH3 domain binding; aging; cellular response to ionizing radiation; cytosol; endosome; epidermal growth factor receptor binding; insulin receptor signaling pathway; positive regulation of reactive oxygen species metabolic process; protein heterooligomerization; receptor internalization; signal transduction in response to DNA damage IPR000108; IPR000980; IPR001452; Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) Grb2 Ash Rattus norvegicus (Rat) TR34315_c0_g8_i4 Q8AY68 SHC1_XENLA 3.00E-07 GO:0005737; GO:0035556; GO:0040008 cytoplasm; intracellular signal transduction; regulation of growth IPR011993; IPR006019; IPR006020; IPR000980; SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) (p60Shc) shc1 Xenopus laevis (African clawed frog) TR34315_c0_g8_i5 P08487 PLCG1_BOVIN 3.00E-07 GO:0008180; GO:0005509; GO:0071364; GO:0001701; GO:0035556; GO:0030027; GO:0004435; GO:0005543; GO:0009395; GO:0010634; GO:0001726; GO:0004871 P22681; O43561-2; Q13094; P09619; P48025; P15498 COP9 signalosome; calcium ion binding; cellular response to epidermal growth factor stimulus; in utero embryonic development; intracellular signal transduction; lamellipodium; phosphatidylinositol phospholipase C activity; phospholipid binding; phospholipid catabolic process; positive regulation of epithelial cell migration; ruffle; signal transducer activity IPR000008; IPR018247; IPR002048; IPR011993; IPR001192; IPR016279; IPR017946; IPR001849; IPR015359; IPR000909; IPR001711; IPR000980; IPR001452; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)" PLCG1 Bos taurus (Bovine) TR34315_c0_g8_i6 P16885 PLCG2_HUMAN 1.00E-07 GO:0030183; GO:0050853; GO:0038095; GO:0038096; GO:0050852; GO:0016055; GO:0032237; GO:0019722; GO:0005829; GO:0002316; GO:0045087; GO:0043647; GO:0032959; GO:0043069; GO:0006661; GO:0004435; GO:0005543; GO:0009395; GO:0005886; GO:0030168; GO:0010468; GO:0051209; GO:0032496; GO:0004871 P00533; P19235; P04626 B cell differentiation; B cell receptor signaling pathway; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; T cell receptor signaling pathway; Wnt receptor signaling pathway; activation of store-operated calcium channel activity; calcium-mediated signaling; cytosol; follicular B cell differentiation; innate immune response; inositol phosphate metabolic process; inositol trisphosphate biosynthetic process; negative regulation of programmed cell death; phosphatidylinositol biosynthetic process; phosphatidylinositol phospholipase C activity; phospholipid binding; phospholipid catabolic process; plasma membrane; platelet activation; regulation of gene expression; release of sequestered calcium ion into cytosol; response to lipopolysaccharide; signal transducer activity IPR000008; IPR011993; IPR001192; IPR016279; IPR017946; IPR001849; IPR015359; IPR000909; IPR001711; IPR000980; IPR001452; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)" PLCG2 Homo sapiens (Human) TR34315_c0_g8_i8 Q62077 PLCG1_MOUSE 2.00E-07 GO:0050852; GO:0005509; GO:0071364; GO:0005829; GO:0001701; GO:0035556; GO:0030027; GO:0004435; GO:0005543; GO:0009395; GO:0010634; GO:0001726; GO:0004871 P14753; Q60631; O54957; P48356 T cell receptor signaling pathway; calcium ion binding; cellular response to epidermal growth factor stimulus; cytosol; in utero embryonic development; intracellular signal transduction; lamellipodium; phosphatidylinositol phospholipase C activity; phospholipid binding; phospholipid catabolic process; positive regulation of epithelial cell migration; ruffle; signal transducer activity IPR000008; IPR011992; IPR018247; IPR002048; IPR011993; IPR001192; IPR016279; IPR017946; IPR001849; IPR015359; IPR000909; IPR001711; IPR000980; IPR001452; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-gamma-1) (PLC-gamma-1)" Plcg1 Plcg-1 Mus musculus (Mouse) TR34316_c7_g2_i2 O70174 ACHA4_MOUSE 7.00E-17 GO:0042113; GO:0006281; GO:0015464; GO:0004889; GO:0005892; GO:0035095; GO:0006816; GO:0030054; GO:0050890; GO:0035640; GO:0009897; GO:0007626; GO:0051899; GO:0045211; GO:0001508; GO:0014059; GO:0060080; GO:0007585; GO:0001666; GO:0006979; GO:0019233; GO:0007271 "B cell activation; DNA repair; acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; behavioral response to nicotine; calcium ion transport; cell junction; cognition; exploration behavior; external side of plasma membrane; locomotory behavior; membrane depolarization; postsynaptic membrane; regulation of action potential; regulation of dopamine secretion; regulation of inhibitory postsynaptic membrane potential; respiratory gaseous exchange; response to hypoxia; response to oxidative stress; sensory perception of pain; synaptic transmission, cholinergic" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-4 Chrna4 Acra4 Mus musculus (Mouse) TR34316_c7_g2_i4 Q91X60 ACHA2_MOUSE 3.00E-21 GO:0015464; GO:0004889; GO:0005892; GO:0030054; GO:0071944; GO:0045211 acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; cell periphery; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-2 Chrna2 Mus musculus (Mouse) TR34316_c7_g3_i2 Q494W8 CRFM7_HUMAN 9.00E-13 GO:0005230; GO:0016021 extracellular ligand-gated ion channel activity; integral to membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; CHRNA7-FAM7A fusion protein (CHRNA7-DR1) (D-10) CHRFAM7A Homo sapiens (Human) TR34318_c1_g2_i1 Q1RMQ5 LIN37_BOVIN 3.00E-13 GO:0007049; GO:0017053 cell cycle; transcriptional repressor complex IPR028226; Protein lin-37 homolog (Antolefinin) LIN37 Bos taurus (Bovine) TR34318_c1_g2_i2 Q9D8N6 LIN37_MOUSE 6.00E-13 GO:0007049; GO:0017053 cell cycle; transcriptional repressor complex IPR028226; Protein lin-37 homolog (Antolefinin) (Antolefinine) Lin37 Mus musculus (Mouse) TR34319_c1_g1_i1 P27096 YAC1_METSO 8.00E-06 Uncharacterized 16.9 kDa protein in acs 3'region (ORF1) Methanosaeta concilii (Methanothrix soehngenii) TR34319_c2_g2_i1 Q14DH7 ACSS3_MOUSE 0 GO:0005524; GO:0003987; GO:0005739 ATP binding; acetate-CoA ligase activity; mitochondrion IPR025110; IPR020845; IPR000873; "Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC 6.2.1.1)" Acss3 Mus musculus (Mouse) TR34319_c2_g2_i4 Q88EH6 ACSA1_PSEPK 1.00E-98 GO:0016208; GO:0005524; GO:0003987; GO:0019427; GO:0046872 AMP binding; ATP binding; acetate-CoA ligase activity; acetyl-CoA biosynthetic process from acetate; metal ion binding IPR011904; IPR025110; IPR020845; IPR000873; Acetyl-coenzyme A synthetase 1 (AcCoA synthetase 1) (Acs 1) (EC 6.2.1.1) (Acetate--CoA ligase 1) (Acyl-activating enzyme 1) acsA1 PP_4487 Pseudomonas putida (strain KT2440) TR34321_c4_g1_i1 Q8NEP9 ZN555_HUMAN 2.00E-09 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 555 ZNF555 Homo sapiens (Human) TR34322_c0_g1_i1 Q8BHH2 RAB9B_MOUSE 5.00E-73 GO:0019003; GO:0005525; GO:0045335; GO:0030670; GO:0005886; GO:0015031; GO:0007264 GDP binding; GTP binding; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-9B Rab9b Mus musculus (Mouse) TR34322_c0_g1_i2 Q8BHH2 RAB9B_MOUSE 4.00E-73 GO:0019003; GO:0005525; GO:0045335; GO:0030670; GO:0005886; GO:0015031; GO:0007264 GDP binding; GTP binding; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-9B Rab9b Mus musculus (Mouse) TR34322_c0_g1_i3 Q9NX57 RAB20_HUMAN 2.00E-11 GO:0005525; GO:0005794; GO:0045335; GO:0030670; GO:0090383; GO:0090385; GO:0015031; GO:0007264 GTP binding; Golgi apparatus; phagocytic vesicle; phagocytic vesicle membrane; phagosome acidification; phagosome-lysosome fusion; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; Ras-related protein Rab-20 RAB20 Homo sapiens (Human) TR34323_c5_g3_i1 Q964E3 ACTC_BIOAL 0 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin, cytoplasmic" Biomphalaria alexandrina (Bloodfluke planorb) (Freshwater snail) TR34323_c5_g3_i2 Q9QZB7 ARP10_MOUSE 4.00E-24 GO:0005737; GO:0005869; GO:0007018 P42025 cytoplasm; dynactin complex; microtubule-based movement IPR004000; IPR027127; Actin-related protein 10 (Actin-related protein 11) Actr10 Act11 Actr11 Arp11 Mus musculus (Mouse) TR34323_c5_g3_i3 Q25379 ACT3_LYTPI 1.00E-112 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; "Actin, cytoskeletal 3 (LPC3) (Fragment)" Lytechinus pictus (Painted sea urchin) TR34323_c5_g3_i4 P84856 ACTB_CERPY 0 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; "Actin, cytoplasmic 1 (Beta-actin)" ACTB Cercopithecus pygerythrus (Vervet monkey) TR34323_c5_g3_i5 Q964E3 ACTC_BIOAL 0 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin, cytoplasmic" Biomphalaria alexandrina (Bloodfluke planorb) (Freshwater snail) TR34323_c5_g3_i6 P10994 ACTS_PLEWA 2.00E-77 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; "Actin, alpha skeletal muscle (Fragment)" Pleurodeles waltl (Iberian ribbed newt) TR34323_c5_g4_i1 P10982 ACT1_ABSGL 1.00E-49 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; Actin-1 (Fragment) ACT1 Absidia glauca (Pin mould) TR34325_c2_g1_i1 A1YF12 ZNF16_GORGO 1.00E-30 GO:0003677; GO:0007049; GO:0051301; GO:0072707; GO:0046872; GO:0043066; GO:0005634; GO:1901989; GO:0051781; GO:0008284; GO:0045648; GO:0033674; GO:0045654; GO:0006355; GO:0006351 "DNA binding; cell cycle; cell division; cellular response to sodium dodecyl sulfate; metal ion binding; negative regulation of apoptotic process; nucleus; positive regulation of cell cycle phase transition; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of kinase activity; positive regulation of megakaryocyte differentiation; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 16 ZNF16 Gorilla gorilla gorilla (Lowland gorilla) TR34327_c3_g1_i1 Q8TGM5 ART3_YEAST 1.00E-17 Putative uncharacterized protein ART3 (Antisense to ribosomal RNA transcript protein 3) ART3 YLR154W-E Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR34327_c4_g1_i7 P0C5P9 YL54B_YEAST 7.00E-11 Putative uncharacterized protein YLR154W-B YLR154W-B smORF398 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR34327_c4_g1_i8 Q6CQE5 TAR1_KLULA 1.00E-29 GO:0005739 mitochondrion Protein TAR1 TAR1-A KLLA0D17600g; TAR1-B KLLA0D17732g; TAR1-C KLLA0D17864g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR34327_c4_g1_i9 Q6CQE5 TAR1_KLULA 2.00E-26 GO:0005739 mitochondrion Protein TAR1 TAR1-A KLLA0D17600g; TAR1-B KLLA0D17732g; TAR1-C KLLA0D17864g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR34329_c4_g1_i2 Q5SS90 CG057_MOUSE 3.00E-18 Uncharacterized protein C7orf57 homolog Gm11992 Mus musculus (Mouse) TR34331_c0_g1_i1 Q99KP3 CRYL1_MOUSE 1.00E-91 GO:0003857; GO:0050104; GO:0070403; GO:0005829; GO:0006631 3-hydroxyacyl-CoA dehydrogenase activity; L-gulonate 3-dehydrogenase activity; NAD+ binding; cytosol; fatty acid metabolic process IPR022694; IPR006180; IPR006176; IPR006108; IPR008927; IPR013328; IPR016040; Lambda-crystallin homolog (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) (Gul3DH) Cryl1 Cry Mus musculus (Mouse) TR34331_c0_g1_i2 P14755 CRYL1_RABIT 1.00E-93 GO:0003857; GO:0050104; GO:0070403; GO:0005829; GO:0006631; GO:0005212 3-hydroxyacyl-CoA dehydrogenase activity; L-gulonate 3-dehydrogenase activity; NAD+ binding; cytosol; fatty acid metabolic process; structural constituent of eye lens IPR022694; IPR006180; IPR006176; IPR006108; IPR008927; IPR013328; IPR016040; Lambda-crystallin (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) (Gul3DH) CRYL1 GUL3DH Oryctolagus cuniculus (Rabbit) TR34332_c0_g1_i1 Q9Z321 TOP3B_MOUSE 0 GO:0005524; GO:0003677; GO:0003917; GO:0006265; GO:0007059; GO:0000793 ATP binding; DNA binding; DNA topoisomerase type I activity; DNA topological change; chromosome segregation; condensed chromosome IPR000380; IPR003601; IPR023406; IPR013497; IPR013824; IPR013825; IPR023405; IPR003602; IPR006171; DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta-1) Top3b Top3b1 Mus musculus (Mouse) TR34334_c0_g1_i1 Q0P457 KTI12_DANRE 3.00E-68 GO:0005524 ATP binding IPR013641; IPR027417; Protein KTI12 homolog kti12 si:dkey-77f17.5 zgc:153393 Danio rerio (Zebrafish) (Brachydanio rerio) TR34334_c0_g3_i1 P34253 KTI12_YEAST 2.00E-18 GO:0005524; GO:0016049; GO:0003682; GO:0005737; GO:0005634; GO:0006357; GO:0002098; GO:0006351 "ATP binding; cell growth; chromatin binding; cytoplasm; nucleus; regulation of transcription from RNA polymerase II promoter; tRNA wobble uridine modification; transcription, DNA-dependent" IPR013641; IPR027417; Protein KTI12 (Gamma-toxin target protein 4) (Killer toxin insensitivity protein 12) KTI12 YKL110C YKL446 YKL500 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR34337_c4_g1_i1 P54318 LIPR2_RAT 4.00E-70 GO:0047372; GO:0005509; GO:0005615; GO:0047714; GO:0019376; GO:0004620; GO:0009395; GO:0009791; GO:0032094; GO:0051384; GO:0043434; GO:0004806; GO:0042589 acylglycerol lipase activity; calcium ion binding; extracellular space; galactolipase activity; galactolipid catabolic process; phospholipase activity; phospholipid catabolic process; post-embryonic development; response to food; response to glucocorticoid stimulus; response to peptide hormone stimulus; triglyceride lipase activity; zymogen granule membrane IPR000734; IPR008976; IPR013818; IPR002331; IPR016272; IPR001024; Pancreatic lipase-related protein 2 (PL-RP2) (EC 3.1.1.26) (EC 3.1.1.3) (Galactolipase) (Secretory glycoprotein GP-3) Pnliprp2 Plrp2 Rattus norvegicus (Rat) TR34337_c4_g1_i2 Q64424 LIPR2_MYOCO 5.00E-74 GO:0047372; GO:0005509; GO:0005615; GO:0047714; GO:0019376; GO:0004620; GO:0009395; GO:0004806 acylglycerol lipase activity; calcium ion binding; extracellular space; galactolipase activity; galactolipid catabolic process; phospholipase activity; phospholipid catabolic process; triglyceride lipase activity IPR000734; IPR008976; IPR013818; IPR002331; IPR016272; IPR001024; Pancreatic lipase-related protein 2 (PL-RP2) (EC 3.1.1.26) (EC 3.1.1.3) (Galactolipase) PNLIPRP2 Myocastor coypus (Coypu) (Nutria) TR34340_c10_g1_i1 Q2PZL6 FAT4_MOUSE 4.00E-15 GO:0045177; GO:0001658; GO:0005509; GO:0048565; GO:0001736; GO:0003007; GO:0007156; GO:0060122; GO:0016021; GO:0001822; GO:0043931; GO:0005886; GO:0007009 apical part of cell; branching involved in ureteric bud morphogenesis; calcium ion binding; digestive tract development; establishment of planar polarity; heart morphogenesis; homophilic cell adhesion; inner ear receptor stereocilium organization; integral to membrane; kidney development; ossification involved in bone maturation; plasma membrane; plasma membrane organization IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) Fat4 Fatj Mus musculus (Mouse) TR34340_c11_g1_i1 Q7TSK3 PCDH8_MOUSE 4.00E-07 GO:0005509; GO:0030054; GO:0030425; GO:0007156; GO:0005887; GO:0016331; GO:0045211; GO:0042734; GO:0001756 calcium ion binding; cell junction; dendrite; homophilic cell adhesion; integral to plasma membrane; morphogenesis of embryonic epithelium; postsynaptic membrane; presynaptic membrane; somitogenesis IPR002126; IPR015919; IPR020894; IPR013164; Protocadherin-8 (Arcadlin) (Paraxial protocadherin) Pcdh8 Papc Mus musculus (Mouse) TR34340_c12_g1_i2 Q6V0I7 FAT4_HUMAN 4.00E-13 GO:0005509; GO:0007156; GO:0016021; GO:0005886 Q9H2K2 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) TR34340_c14_g1_i1 O95206 PCDH8_HUMAN 5.00E-07 GO:0005509; GO:0030054; GO:0007267; GO:0030425; GO:0007156; GO:0005887; GO:0016331; GO:0045211; GO:0042734; GO:0001756; GO:0007268 calcium ion binding; cell junction; cell-cell signaling; dendrite; homophilic cell adhesion; integral to plasma membrane; morphogenesis of embryonic epithelium; postsynaptic membrane; presynaptic membrane; somitogenesis; synaptic transmission IPR002126; IPR015919; IPR020894; IPR013164; Protocadherin-8 (Arcadlin) PCDH8 Homo sapiens (Human) TR34340_c5_g1_i1 P34616 CADH3_CAEEL 9.00E-10 GO:0005509; GO:0030054; GO:0005737; GO:0007156; GO:0016021; GO:0016331; GO:0005886; GO:0005198; GO:0045138 calcium ion binding; cell junction; cytoplasm; homophilic cell adhesion; integral to membrane; morphogenesis of embryonic epithelium; plasma membrane; structural molecule activity; tail tip morphogenesis IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR013032; IPR001791; Cadherin-3 cdh-3 ZK112.7 Caenorhabditis elegans TR34340_c7_g2_i1 Q5DRE7 PCDA5_PANTR 7.00E-10 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR013164; Protocadherin alpha-5 (PCDH-alpha-5) PCDHA5 Pan troglodytes (Chimpanzee) TR34340_c7_g2_i2 Q9NYQ7 CELR3_HUMAN 5.00E-13 GO:0004930; GO:0007413; GO:0005509; GO:0042384; GO:0007156; GO:0016021; GO:0001764; GO:0007218; GO:0005886; GO:0032880 P16333 G-protein coupled receptor activity; axonal fasciculation; calcium ion binding; cilium assembly; homophilic cell adhesion; integral to membrane; neuron migration; neuropeptide signaling pathway; plasma membrane; regulation of protein localization IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR013032; IPR002049; IPR017981; IPR001879; IPR000832; IPR017983; IPR000203; IPR001791; Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) CELSR3 CDHF11 EGFL1 FMI1 KIAA0812 MEGF2 Homo sapiens (Human) TR34342_c2_g2_i2 Q9ULT0 TTC7A_HUMAN 3.00E-30 GO:0006879; GO:0030097 cellular iron ion homeostasis; hemopoiesis IPR013026; IPR011990; IPR001440; IPR019734; IPR026900; Tetratricopeptide repeat protein 7A (TPR repeat protein 7A) TTC7A KIAA1140 TTC7 Homo sapiens (Human) TR34342_c2_g2_i4 Q86TV6 TTC7B_HUMAN 5.00E-35 IPR013026; IPR011990; IPR013105; IPR019734; IPR026900; Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1) TTC7B TTC7L1 Homo sapiens (Human) TR34344_c0_g1_i2 Q9NVU0 RPC5_HUMAN 5.00E-166 GO:0003899; GO:0005829; GO:0051607; GO:0045087; GO:0005654; GO:0032481; GO:0006386; GO:0006385 DNA-directed RNA polymerase activity; cytosol; defense response to virus; innate immune response; nucleoplasm; positive regulation of type I interferon production; termination of RNA polymerase III transcription; transcription elongation from RNA polymerase III promoter IPR006886; DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide) POLR3E KIAA1452 Homo sapiens (Human) TR34346_c1_g2_i1 Q696W0 SPEG_DANRE 2.00E-14 GO:0005524; GO:0030018; GO:0007517; GO:0005634; GO:0004672; GO:0004674 ATP binding; Z disc; muscle organ development; nucleus; protein kinase activity; protein serine/threonine kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR020675; IPR000719; IPR017441; IPR002290; IPR015726; IPR008271; Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) speg apeg1 Danio rerio (Zebrafish) (Brachydanio rerio) TR34347_c0_g1_i1 Q499R4 YRDC_RAT 1.00E-61 GO:0003725; GO:0016020; GO:0005739; GO:0051051 double-stranded RNA binding; membrane; mitochondrion; negative regulation of transport IPR017945; IPR006070; "YrdC domain-containing protein, mitochondrial (Ischemia/reperfusion-inducible protein homolog)" Yrdc Isrip Rattus norvegicus (Rat) TR34351_c0_g1_i1 Q5XIK8 CTSL2_RAT 2.00E-102 GO:0016311; GO:0004721 dephosphorylation; phosphoprotein phosphatase activity IPR011948; IPR023214; IPR004274; CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-) Ctdspl2 Rattus norvegicus (Rat) TR34352_c2_g1_i1 Q61738 ITA7_MOUSE 3.00E-27 GO:0034677; GO:0048514; GO:0007155; GO:0016477; GO:0005737; GO:0007229; GO:0046872; GO:0005927; GO:0031594; GO:0008360; GO:0042383 Q8C2K1; Q6A028 alpha7-beta1 integrin complex; blood vessel morphogenesis; cell adhesion; cell migration; cytoplasm; integrin-mediated signaling pathway; metal ion binding; muscle tendon junction; neuromuscular junction; regulation of cell shape; sarcolemma IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain] Itga7 Mus musculus (Mouse) TR34352_c2_g1_i2 Q00651 ITA4_MOUSE 3.00E-64 GO:0001974; GO:0016477; GO:0005911; GO:0007160; GO:0060710; GO:0009897; GO:0060324; GO:0001968; GO:0007157; GO:0008305; GO:0007229; GO:0007159; GO:0060485; GO:0046872; GO:0061032 blood vessel remodeling; cell migration; cell-cell junction; cell-matrix adhesion; chorio-allantoic fusion; external side of plasma membrane; face development; fibronectin binding; heterophilic cell-cell adhesion; integrin complex; integrin-mediated signaling pathway; leukocyte cell-cell adhesion; mesenchyme development; metal ion binding; visceral serous pericardium development IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (Lymphocyte Peyer patch adhesion molecules subunit alpha) (LPAM subunit alpha) (VLA-4 subunit alpha) (CD antigen CD49d) Itga4 Mus musculus (Mouse) TR34355_c0_g1_i1 Q80YD6 SRGEF_MOUSE 2.00E-74 GO:0005087; GO:0005737; GO:0045111; GO:0050709; GO:0005730; GO:0005634 Ran guanyl-nucleotide exchange factor activity; cytoplasm; intermediate filament cytoskeleton; negative regulation of protein secretion; nucleolus; nucleus IPR027048; IPR009091; IPR000408; Secretion-regulating guanine nucleotide exchange factor (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF) (Guanine nucleotide exchange factor-related protein) Sergef Delgef Gnefr Mus musculus (Mouse) TR34356_c0_g1_i1 Q502K3 ANR52_DANRE 2.00E-28 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) TR34357_c0_g1_i1 Q6LWU0 SYD_METMP 3.00E-57 GO:0005524; GO:0004815; GO:0006422; GO:0005737; GO:0000287; GO:0003676 ATP binding; aspartate-tRNA ligase activity; aspartyl-tRNA aminoacylation; cytoplasm; magnesium ion binding; nucleic acid binding IPR004364; IPR018150; IPR006195; IPR020780; IPR004523; IPR002312; IPR012340; IPR004365; Aspartate--tRNA ligase (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) aspS MMP1616 Methanococcus maripaludis (strain S2 / LL) TR34357_c0_g1_i2 Q2KJG3 SYNC_BOVIN 0 GO:0005524; GO:0004816; GO:0006421; GO:0005737; GO:0003676 ATP binding; asparagine-tRNA ligase activity; asparaginyl-tRNA aminoacylation; cytoplasm; nucleic acid binding IPR004364; IPR018150; IPR006195; IPR004522; IPR002312; IPR012340; IPR004365; "Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS)" NARS Bos taurus (Bovine) TR34357_c0_g1_i3 Q2KJG3 SYNC_BOVIN 0 GO:0005524; GO:0004816; GO:0006421; GO:0005737; GO:0003676 ATP binding; asparagine-tRNA ligase activity; asparaginyl-tRNA aminoacylation; cytoplasm; nucleic acid binding IPR004364; IPR018150; IPR006195; IPR004522; IPR002312; IPR012340; IPR004365; "Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS)" NARS Bos taurus (Bovine) TR34360_c5_g1_i1 Q8CB62 CNTRB_MOUSE 4.00E-21 GO:0005814; GO:0007099; GO:0051299; GO:0000910 centriole; centriole replication; centrosome separation; cytokinesis Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8) Cntrob Lip8 Mus musculus (Mouse) TR34361_c0_g1_i2 Q13489 BIRC3_HUMAN 6.00E-19 GO:0038061; GO:0035666; GO:0006915; GO:0007166; GO:0005829; GO:0045087; GO:0070266; GO:0043066; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0043123; GO:0039535; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0034138; GO:0034142; GO:0004842; GO:0008270 Q13546; O43353; Q9Y572; P57078; Q12933 NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; apoptotic process; cell surface receptor signaling pathway; cytosol; innate immune response; necroptosis; negative regulation of apoptotic process; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of RIG-I signaling pathway; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Apoptosis inhibitor 2) (API2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (IAP-1) (hIAP-1) (hIAP1) (RING finger protein 49) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 IAP1 MIHC RNF49 Homo sapiens (Human) TR34361_c0_g1_i5 Q13489 BIRC3_HUMAN 8.00E-19 GO:0038061; GO:0035666; GO:0006915; GO:0007166; GO:0005829; GO:0045087; GO:0070266; GO:0043066; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0043123; GO:0039535; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0034138; GO:0034142; GO:0004842; GO:0008270 Q13546; O43353; Q9Y572; P57078; Q12933 NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; apoptotic process; cell surface receptor signaling pathway; cytosol; innate immune response; necroptosis; negative regulation of apoptotic process; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of RIG-I signaling pathway; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Apoptosis inhibitor 2) (API2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (IAP-1) (hIAP-1) (hIAP1) (RING finger protein 49) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 IAP1 MIHC RNF49 Homo sapiens (Human) TR34362_c0_g1_i2 Q9PVW8 SAL_SILAS 2.00E-10 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR000922; Rhamnose-binding lectin (RBL) (Roe lectin) (SAL) Silurus asotus (Amur catfish) (Parasilurus asotus) TR34362_c0_g1_i3 B3MFV7 LPHN_DROAN 4.00E-11 GO:0004930; GO:0030246; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; carbohydrate binding; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR000203; IPR000922; Latrophilin Cirl Cirl GF12369 Drosophila ananassae (Fruit fly) TR34362_c0_g1_i4 P86177 CSL1_ONCKE 8.00E-10 GO:0030246 carbohydrate binding IPR000922; L-rhamnose-binding lectin CSL1 Oncorhynchus keta (Chum salmon) (Salmo keta) TR34364_c0_g1_i1 O14360 NAF1_SCHPO 5.00E-12 GO:0000493; GO:0005635; GO:0005730; GO:0005654; GO:0001522; GO:0006364; GO:0030529; GO:0030515 box H/ACA snoRNP assembly; nuclear envelope; nucleolus; nucleoplasm; pseudouridine synthesis; rRNA processing; ribonucleoprotein complex; snoRNA binding IPR007504; IPR009000; H/ACA ribonucleoprotein complex non-core subunit NAF1 (Nuclear assembly factor 1) naf1 SPBC30D10.15 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR34364_c0_g1_i5 Q52KK4 NAF1_RAT 2.00E-39 GO:0003723; GO:0030054; GO:0005813; GO:0005737; GO:0005634; GO:0001522; GO:0006364; GO:0042254; GO:0005732 RNA binding; cell junction; centrosome; cytoplasm; nucleus; pseudouridine synthesis; rRNA processing; ribosome biogenesis; small nucleolar ribonucleoprotein complex IPR007504; IPR009000; H/ACA ribonucleoprotein complex non-core subunit NAF1 Naf1 Rattus norvegicus (Rat) TR34365_c7_g1_i1 Q0VDG4 SCRN3_HUMAN 2.00E-07 GO:0016805; GO:0006508 dipeptidase activity; proteolysis IPR005322; Secernin-3 SCRN3 Homo sapiens (Human) TR34365_c7_g1_i2 Q5TYS5 SCRN2_DANRE 1.00E-17 GO:0016805; GO:0006508 dipeptidase activity; proteolysis IPR005322; Secernin-2 scrn2 si:ch211-184m19.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR34367_c0_g3_i1 Q10980 FUT1_RAT 1.00E-16 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha 1,2-fucosyltransferase A) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" Fut1 Fta Rattus norvegicus (Rat) TR34370_c1_g1_i1 P0DKQ8 ACTP_CONCN 1.00E-35 GO:0019835; GO:0044179; GO:0016021; GO:0006811; GO:0044218 cytolysis; hemolysis in other organism; integral to membrane; ion transport; other organism cell membrane IPR015926; Conoporin-Cn1 Conus consors (Singed cone) TR34370_c1_g1_i3 P0DKQ8 ACTP_CONCN 1.00E-34 GO:0019835; GO:0044179; GO:0016021; GO:0006811; GO:0044218 cytolysis; hemolysis in other organism; integral to membrane; ion transport; other organism cell membrane IPR015926; Conoporin-Cn1 Conus consors (Singed cone) TR34374_c2_g1_i1 Q9ESM0 IP6K1_RAT 8.00E-48 GO:0005524; GO:0005737; GO:0052723; GO:0052724; GO:0000832; GO:0008440; GO:0005730; GO:0046854 "ATP binding; cytoplasm; inositol hexakisphosphate 1-kinase activity; inositol hexakisphosphate 3-kinase activity; inositol hexakisphosphate 5-kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; nucleolus; phosphatidylinositol phosphorylation" IPR005522; Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1) Ip6k1 Ihpk1 Rattus norvegicus (Rat) TR34375_c6_g1_i1 Q9Y251 HPSE_HUMAN 7.00E-100 GO:0004566; GO:0005975; GO:0007160; GO:0005576; GO:0006027; GO:0030200; GO:0030305; GO:0043202; GO:0005765; GO:0045121; GO:0005634; GO:0030194; GO:0051798; GO:0033690; GO:0051897; GO:0010575; GO:0046983; GO:0051797; GO:0045545; GO:0061042 beta-glucuronidase activity; carbohydrate metabolic process; cell-matrix adhesion; extracellular region; glycosaminoglycan catabolic process; heparan sulfate proteoglycan catabolic process; heparanase activity; lysosomal lumen; lysosomal membrane; membrane raft; nucleus; positive regulation of blood coagulation; positive regulation of hair follicle development; positive regulation of osteoblast proliferation; positive regulation of protein kinase B signaling cascade; positive regulation vascular endothelial growth factor production; protein dimerization activity; regulation of hair follicle development; syndecan binding; vascular wound healing IPR005199; IPR013781; IPR017853; Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit] HPSE HEP HPA HPA1 HPR1 HPSE1 HSE1 Homo sapiens (Human) TR34375_c6_g1_i3 Q9Y251 HPSE_HUMAN 8.00E-100 GO:0004566; GO:0005975; GO:0007160; GO:0005576; GO:0006027; GO:0030200; GO:0030305; GO:0043202; GO:0005765; GO:0045121; GO:0005634; GO:0030194; GO:0051798; GO:0033690; GO:0051897; GO:0010575; GO:0046983; GO:0051797; GO:0045545; GO:0061042 beta-glucuronidase activity; carbohydrate metabolic process; cell-matrix adhesion; extracellular region; glycosaminoglycan catabolic process; heparan sulfate proteoglycan catabolic process; heparanase activity; lysosomal lumen; lysosomal membrane; membrane raft; nucleus; positive regulation of blood coagulation; positive regulation of hair follicle development; positive regulation of osteoblast proliferation; positive regulation of protein kinase B signaling cascade; positive regulation vascular endothelial growth factor production; protein dimerization activity; regulation of hair follicle development; syndecan binding; vascular wound healing IPR005199; IPR013781; IPR017853; Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit] HPSE HEP HPA HPA1 HPR1 HPSE1 HSE1 Homo sapiens (Human) TR34376_c2_g1_i1 Q01241 NF70_LOLPE 3.00E-164 GO:0005882; GO:0005198 intermediate filament; structural molecule activity IPR001664; IPR016451; IPR018039; IPR001322; 70 kDa neurofilament protein (NF70) Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR34376_c2_g1_i3 P48673 VIMB_CARAU 8.00E-33 GO:0005882; GO:0005198 intermediate filament; structural molecule activity IPR001664; IPR006821; IPR018039; IPR027699; Vimentin beta Carassius auratus (Goldfish) TR34376_c2_g1_i4 Q19286 IFB2_CAEEL 7.00E-59 GO:0045179; GO:0005882; GO:0005198 A7DTF5 apical cortex; intermediate filament; structural molecule activity IPR001664; IPR016451; Intermediate filament protein ifb-2 (Cel IF B2) (Intermediate filament protein B2) (IF-B2) ifb-2 F10C1.7 Caenorhabditis elegans TR34376_c2_g1_i5 Q3ZD69 LMNA_PIG 2.00E-52 GO:0005882; GO:0005635; GO:0090343; GO:0034504; GO:0005198 intermediate filament; nuclear envelope; positive regulation of cell aging; protein localization to nucleus; structural molecule activity IPR001664; IPR018039; IPR001322; Prelamin-A/C [Cleaved into: Lamin-A/C] LMNA Sus scrofa (Pig) TR34376_c2_g1_i7 Q01241 NF70_LOLPE 0 GO:0005882; GO:0005198 intermediate filament; structural molecule activity IPR001664; IPR016451; IPR018039; IPR001322; 70 kDa neurofilament protein (NF70) Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR34376_c2_g3_i1 Q9MZA9 VIME_SHEEP 2.00E-11 GO:0005882; GO:0005198 intermediate filament; structural molecule activity IPR001664; IPR006821; IPR027699; Vimentin (Fragment) VIM Ovis aries (Sheep) TR34377_c5_g1_i1 Q86SG6 NEK8_HUMAN 3.00E-103 GO:0005524; GO:0005737; GO:0005856; GO:0046872; GO:0009887; GO:0072372; GO:0004674; GO:0035330 ATP binding; cytoplasm; cytoskeleton; metal ion binding; organ morphogenesis; primary cilium; protein serine/threonine kinase activity; regulation of hippo signaling cascade IPR011009; IPR000719; IPR017441; IPR009091; IPR000408; IPR002290; IPR008271; Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a) NEK8 JCK NEK12A Homo sapiens (Human) TR34377_c5_g2_i1 P11837 NIMA_EMENI 1.00E-26 GO:0005524; GO:0000086; GO:0051301; GO:0007059; GO:0043987; GO:0007067; GO:0005634; GO:0045840; GO:0004674 ATP binding; G2/M transition of mitotic cell cycle; cell division; chromosome segregation; histone H3-S10 phosphorylation; mitosis; nucleus; positive regulation of mitosis; protein serine/threonine kinase activity IPR011009; IPR000719; IPR002290; IPR008271; G2-specific protein kinase nimA (EC 2.7.11.1) (Never in mitosis) nimA AN9504 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR34377_c9_g1_i1 Q6PAV2 HERC4_MOUSE 1.00E-11 GO:0030154; GO:0005737; GO:0005829; GO:0005634; GO:0042787; GO:0007283; GO:0004842 cell differentiation; cytoplasm; cytosol; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; spermatogenesis; ubiquitin-protein ligase activity IPR000569; IPR009091; IPR000408; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HERC4 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 4) Herc4 Mus musculus (Mouse) TR34377_c9_g2_i1 Q90XC2 NEK8_DANRE 1.00E-128 GO:0005524; GO:0051301; GO:0005737; GO:0001947; GO:0046872; GO:0007067; GO:0072372; GO:0072116; GO:0004674; GO:0061326 ATP binding; cell division; cytoplasm; heart looping; metal ion binding; mitosis; primary cilium; pronephros formation; protein serine/threonine kinase activity; renal tubule development IPR011009; IPR000719; IPR017441; IPR009091; IPR000408; IPR002290; IPR008271; Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) nek8 Danio rerio (Zebrafish) (Brachydanio rerio) TR34379_c0_g1_i7 Q9Z0S9 PRAF1_MOUSE 1.00E-35 GO:0005794; GO:0030054; GO:0016021; GO:0005886; GO:0008021 P01112; Q9JKS6; P61586 Golgi apparatus; cell junction; integral to membrane; plasma membrane; synaptic vesicle IPR004895; Prenylated Rab acceptor protein 1 (PRA1 family protein 1) (Prenylin) Rabac1 Pra Pra1 Praf1 Mus musculus (Mouse) TR34380_c0_g1_i1 Q90Y57 JAG1A_DANRE 4.00E-111 GO:0007219; GO:0005509; GO:0016021; GO:0007275 Notch signaling pathway; calcium ion binding; integral to membrane; multicellular organismal development IPR001774; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR026219; IPR011651; IPR001007; Protein jagged-1a (Jagged1) (Jagged1a) jag1a jag1 Danio rerio (Zebrafish) (Brachydanio rerio) TR34381_c2_g5_i1 P54288 CACB2_RABIT 2.00E-148 GO:0042383; GO:0005245; GO:0005891 sarcolemma; voltage-gated calcium channel activity; voltage-gated calcium channel complex IPR008145; IPR027417; IPR001452; IPR005444; IPR000584; Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) CACNB2 CACNLB2 Oryctolagus cuniculus (Rabbit) TR34381_c2_g5_i3 Q8VGC3 CACB2_RAT 9.00E-146 GO:0005246; GO:0019901; GO:0042383; GO:0005245; GO:0005891 calcium channel regulator activity; protein kinase binding; sarcolemma; voltage-gated calcium channel activity; voltage-gated calcium channel complex IPR008145; IPR027417; IPR001452; IPR005444; IPR000584; Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) Cacnb2 Cacnlb2 Rattus norvegicus (Rat) TR34381_c2_g5_i5 P54288 CACB2_RABIT 2.00E-149 GO:0042383; GO:0005245; GO:0005891 sarcolemma; voltage-gated calcium channel activity; voltage-gated calcium channel complex IPR008145; IPR027417; IPR001452; IPR005444; IPR000584; Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) CACNB2 CACNLB2 Oryctolagus cuniculus (Rabbit) TR34381_c2_g5_i6 P54288 CACB2_RABIT 3.00E-148 GO:0042383; GO:0005245; GO:0005891 sarcolemma; voltage-gated calcium channel activity; voltage-gated calcium channel complex IPR008145; IPR027417; IPR001452; IPR005444; IPR000584; Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) CACNB2 CACNLB2 Oryctolagus cuniculus (Rabbit) TR34384_c0_g1_i1 Q96DI7 SNR40_HUMAN 1.00E-11 GO:0005682; GO:0071013; GO:0005737; GO:0000398; GO:0005654; GO:0005732 Q6P2Q9 "U5 snRNP; catalytic step 2 spliceosome; cytoplasm; mRNA splicing, via spliceosome; nucleoplasm; small nucleolar ribonucleoprotein complex" IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; U5 small nuclear ribonucleoprotein 40 kDa protein (U5 snRNP 40 kDa protein) (U5-40K) (38 kDa-splicing factor) (Prp8-binding protein) (hPRP8BP) (U5 snRNP-specific 40 kDa protein) (WD repeat-containing protein 57) SNRNP40 PRP8BP SFP38 WDR57 Homo sapiens (Human) TR34384_c2_g1_i3 Q3TLR7 DTL_MOUSE 3.00E-65 GO:0031464; GO:0031465; GO:0006260; GO:0031572; GO:0005813; GO:0005694; GO:0005737; GO:0031965; GO:0005634; GO:0006513; GO:0000209; GO:0051726; GO:0009411; GO:0019985; GO:0006511; GO:0004842 Cul4A-RING ubiquitin ligase complex; Cul4B-RING ubiquitin ligase complex; DNA replication; G2 DNA damage checkpoint; centrosome; chromosome; cytoplasm; nuclear membrane; nucleus; protein monoubiquitination; protein polyubiquitination; regulation of cell cycle; response to UV; translesion synthesis; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. Denticleless protein homolog (Lethal(2) denticleless protein homolog) (Meth A retinoic acid-regulated nuclear matrix-associated protein) (Meth A RAMP) (Retinoic acid-regulated nuclear matrix-associated protein) Dtl Cdt2 L2dtl Ramp Mus musculus (Mouse) TR34385_c4_g1_i1 P85515 ACTZ_RAT 7.00E-124 GO:0005524; GO:0005813; GO:0005737 ATP binding; centrosome; cytoplasm IPR004000; IPR020902; IPR004001; Alpha-centractin (Centractin) Actr1a Ctrn1 Rattus norvegicus (Rat) TR34385_c4_g2_i1 Q54L54 ACT29_DICDI 6.00E-40 GO:0005524; GO:0015629; GO:0000902; GO:0005737; GO:0017022; GO:0005200 ATP binding; actin cytoskeleton; cell morphogenesis; cytoplasm; myosin binding; structural constituent of cytoskeleton IPR004000; Putative actin-29 act29 DDB_G0286893 Dictyostelium discoideum (Slime mold) TR34385_c4_g2_i2 Q54I79 ACTY_DICDI 2.00E-82 GO:0005524; GO:0005813; GO:0005737; GO:0016192 ATP binding; centrosome; cytoplasm; vesicle-mediated transport IPR004000; IPR004001; Centractin (Actin-related protein A) arpA Arp1 DDB_G0288937 Dictyostelium discoideum (Slime mold) TR34385_c4_g2_i3 Q24733 ACT_DICVI 6.00E-07 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; Actin (Fragment) Dictyocaulus viviparus (Bovine lungworm) TR34385_c4_g2_i4 P24902 ACT_PINCO 1.00E-48 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; Actin (Fragment) Pinus contorta (Shore pine) (Lodgepole pine) TR34386_c3_g2_i2 P0CB42 ALKB1_MOUSE 3.00E-52 GO:0006307; GO:0080111; GO:0003906; GO:0042245; GO:0042056; GO:0048589; GO:0008198; GO:0001701; GO:0070579; GO:0005739; GO:0043524; GO:0001764; GO:0031175; GO:0005719; GO:0070989; GO:0001890 DNA dealkylation involved in DNA repair; DNA demethylation; DNA-(apurinic or apyrimidinic site) lyase activity; RNA repair; chemoattractant activity; developmental growth; ferrous iron binding; in utero embryonic development; methylcytosine dioxygenase activity; mitochondrion; negative regulation of neuron apoptotic process; neuron migration; neuron projection development; nuclear euchromatin; oxidative demethylation; placenta development IPR004574; IPR027450; IPR005123; Alkylated DNA repair protein alkB homolog 1 (EC 1.14.11.33) (Alpha-ketoglutarate-dependent dioxygenase ABH1) (DNA lyase ABH1) (EC 4.2.99.18) (DNA oxidative demethylase ALKBH1) Alkbh1 Abh Alkbh Mus musculus (Mouse) TR34386_c3_g2_i4 Q54N08 ALKB_DICDI 2.00E-30 GO:0006281; GO:0051213; GO:0046872 DNA repair; dioxygenase activity; metal ion binding IPR027450; Alpha-ketoglutarate-dependent dioxygenase alkB (EC 1.14.11.-) (Alkylated DNA repair protein alkB) alkB DDB_G0285575 Dictyostelium discoideum (Slime mold) TR34386_c3_g2_i6 P05050 ALKB_ECOLI 5.00E-17 GO:0006307; GO:0043734; GO:0042245; GO:0051747; GO:0008198; GO:0035515; GO:0035552; GO:0035553 DNA dealkylation involved in DNA repair; DNA-N1-methyladenine dioxygenase activity; RNA repair; cytosine C-5 DNA demethylase activity; ferrous iron binding; oxidative RNA demethylase activity; oxidative single-stranded DNA demethylation; oxidative single-stranded RNA demethylation IPR004574; IPR027450; IPR005123; Alpha-ketoglutarate-dependent dioxygenase AlkB (EC 1.14.11.33) (Alkylated DNA repair protein AlkB) (DNA oxidative demethylase AlkB) alkB aidD b2212 JW2200 Escherichia coli (strain K12) TR34386_c3_g2_i7 P0CB42 ALKB1_MOUSE 4.00E-22 GO:0006307; GO:0080111; GO:0003906; GO:0042245; GO:0042056; GO:0048589; GO:0008198; GO:0001701; GO:0070579; GO:0005739; GO:0043524; GO:0001764; GO:0031175; GO:0005719; GO:0070989; GO:0001890 DNA dealkylation involved in DNA repair; DNA demethylation; DNA-(apurinic or apyrimidinic site) lyase activity; RNA repair; chemoattractant activity; developmental growth; ferrous iron binding; in utero embryonic development; methylcytosine dioxygenase activity; mitochondrion; negative regulation of neuron apoptotic process; neuron migration; neuron projection development; nuclear euchromatin; oxidative demethylation; placenta development IPR004574; IPR027450; IPR005123; Alkylated DNA repair protein alkB homolog 1 (EC 1.14.11.33) (Alpha-ketoglutarate-dependent dioxygenase ABH1) (DNA lyase ABH1) (EC 4.2.99.18) (DNA oxidative demethylase ALKBH1) Alkbh1 Abh Alkbh Mus musculus (Mouse) TR34387_c5_g1_i1 Q969W1 ZDH16_HUMAN 1.00E-74 GO:0006915; GO:0005789; GO:0016021; GO:0016746; GO:0008270 "apoptotic process; endoplasmic reticulum membrane; integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Probable palmitoyltransferase ZDHHC16 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 16) (DHHC-16) ZDHHC16 UNQ2570/PRO6258 Homo sapiens (Human) TR34389_c0_g1_i2 Q9NVM6 DJC17_HUMAN 5.00E-64 GO:0003723; GO:0000166 RNA binding; nucleotide binding IPR001623; IPR012677; DnaJ homolog subfamily C member 17 DNAJC17 Homo sapiens (Human) TR34389_c0_g1_i3 Q99M87 DNJA3_MOUSE 2.00E-09 GO:0005524; GO:0033256; GO:0008385; GO:0033077; GO:0005884; GO:0006919; GO:0006924; GO:0007569; GO:0030054; GO:0005829; GO:0009790; GO:0019897; GO:0046872; GO:0006264; GO:0042645; GO:0005739; GO:0043124; GO:0032088; GO:0043066; GO:0008285; GO:0043154; GO:0060336; GO:0006469; GO:0000122; GO:0031594; GO:0007528; GO:0005634; GO:0042102; GO:0043065; GO:0031398; GO:0045211; GO:0006457; GO:0050821; GO:0009408; GO:0034341; GO:0071340; GO:0007264; GO:0005083 ATP binding; I-kappaB/NF-kappaB complex; IkappaB kinase complex; T cell differentiation in thymus; actin filament; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation-induced cell death of T cells; cell aging; cell junction; cytosol; embryo development; extrinsic to plasma membrane; metal ion binding; mitochondrial DNA replication; mitochondrial nucleoid; mitochondrion; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of apoptotic process; negative regulation of cell proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of interferon-gamma-mediated signaling pathway; negative regulation of protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; neuromuscular junction; neuromuscular junction development; nucleus; positive regulation of T cell proliferation; positive regulation of apoptotic process; positive regulation of protein ubiquitination; postsynaptic membrane; protein folding; protein stabilization; response to heat; response to interferon-gamma; skeletal muscle acetylcholine-gated channel clustering; small GTPase mediated signal transduction; small GTPase regulator activity IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; "DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (mTid-1) (Tumorous imaginal discs protein Tid56 homolog)" Dnaja3 Tid1 Mus musculus (Mouse) TR34390_c0_g1_i1 P86964 KCP3_PINMA 4.00E-13 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; BPTI/Kunitz domain-containing protein 3 (Nacre serine protease inhibitor 2) (NSPI2) Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) TR34390_c0_g1_i2 P86964 KCP3_PINMA 4.00E-13 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; BPTI/Kunitz domain-containing protein 3 (Nacre serine protease inhibitor 2) (NSPI2) Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) TR34393_c0_g2_i1 A2RUC4 TYW5_HUMAN 3.00E-136 GO:0005506; GO:0016706; GO:0042803; GO:0000049; GO:0031591 "iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; protein homodimerization activity; tRNA binding; wybutosine biosynthetic process" IPR003347; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. tRNA wybutosine-synthesizing protein 5 (hTYW5) (EC 1.14.11.42) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase) TYW5 C2orf60 Homo sapiens (Human) TR34393_c0_g2_i2 Q6C3P4 LCMT2_YARLI 2.00E-45 GO:0008168; GO:0008033 methyltransferase activity; tRNA processing IPR011043; IPR003347; IPR015915; IPR007213; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. Leucine carboxyl methyltransferase 2 (EC 2.1.1.-) (tRNA wybutosine-synthesizing protein 4) PPM2 TYW4 YALI0E33209g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR34393_c0_g2_i4 E1C7T6 TYW5_CHICK 1.00E-138 GO:0005506; GO:0016706; GO:0042803; GO:0000049; GO:0031591 "iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; protein homodimerization activity; tRNA binding; wybutosine biosynthetic process" IPR003347; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. tRNA wybutosine-synthesizing protein 5 (EC 1.14.11.42) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase) TYW5 Gallus gallus (Chicken) TR34395_c0_g1_i1 Q6AXQ0 SAE1_RAT 6.00E-34 GO:0019948; GO:0016874; GO:0005634; GO:0008022; GO:0016925 SUMO activating enzyme activity; ligase activity; nucleus; protein C-terminus binding; protein sumoylation IPR009036; IPR016040; IPR000594; IPR000011; Protein modification; protein sumoylation. "SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed]" Sae1 Uble1a Rattus norvegicus (Rat) TR34395_c0_g1_i3 Q9R1T2 SAE1_MOUSE 2.00E-32 GO:0019948; GO:0016874; GO:0005634; GO:0008022; GO:0016925 SUMO activating enzyme activity; ligase activity; nucleus; protein C-terminus binding; protein sumoylation IPR009036; IPR016040; IPR000594; IPR000011; Protein modification; protein sumoylation. "SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed]" Sae1 Aos1 Sua1 Ubl1a1 Uble1a Mus musculus (Mouse) TR34395_c0_g2_i1 A3KMV5 UBA1_BOVIN 0 GO:0005524; GO:0016874; GO:0016567; GO:0008641 ATP binding; ligase activity; protein ubiquitination; small protein activating enzyme activity IPR009036; IPR016040; IPR000594; IPR018965; IPR023280; IPR000127; IPR019572; IPR018075; IPR018074; IPR000011; Protein modification; protein ubiquitination. Ubiquitin-like modifier-activating enzyme 1 (Ubiquitin-activating enzyme E1) UBA1 UBE1 Bos taurus (Bovine) TR34400_c0_g1_i1 Q803X1 CTU1_DANRE 0 GO:0005524; GO:0005829; GO:0000049; GO:0034227; GO:0002098; GO:0016740 ATP binding; cytosol; tRNA binding; tRNA thio-modification; tRNA wobble uridine modification; transferase activity IPR012089; IPR014729; IPR011063; IPR000541; IPR020554; tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. Cytoplasmic tRNA 2-thiolation protein 1 (EC 2.7.7.-) (ATP-binding domain-containing protein 3) (Cytoplasmic tRNA adenylyltransferase 1) ctu1 atpbd3 ncs6 zgc:55395 Danio rerio (Zebrafish) (Brachydanio rerio) TR34401_c0_g1_i1 Q64520 KGUA_MOUSE 1.00E-72 GO:0005524; GO:0004385; GO:0006163 ATP binding; guanylate kinase activity; purine nucleotide metabolic process IPR008145; IPR008144; IPR017665; IPR020590; IPR027417; Guanylate kinase (EC 2.7.4.8) (GMP kinase) Guk1 Gmk Mus musculus (Mouse) TR34401_c0_g1_i2 Q64520 KGUA_MOUSE 1.00E-72 GO:0005524; GO:0004385; GO:0006163 ATP binding; guanylate kinase activity; purine nucleotide metabolic process IPR008145; IPR008144; IPR017665; IPR020590; IPR027417; Guanylate kinase (EC 2.7.4.8) (GMP kinase) Guk1 Gmk Mus musculus (Mouse) TR34402_c4_g2_i1 Q9Y575 ASB3_HUMAN 5.00E-09 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 3 (ASB-3) ASB3 Homo sapiens (Human) TR34402_c4_g3_i1 Q5RF15 TNI3K_PONAB 2.00E-13 GO:0005524; GO:0005737; GO:0046872; GO:0005634; GO:0004674 ATP binding; cytoplasm; metal ion binding; nucleus; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR017441; IPR001245; Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3-interacting kinase) TNNI3K Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34402_c4_g3_i2 Q502M6 ANR29_DANRE 7.00E-19 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) TR34402_c4_g3_i3 Q3UMT1 PP12C_MOUSE 1.00E-06 GO:0005737 cytoplasm IPR002110; IPR020683; IPR017401; Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) Ppp1r12c Mbs85 Mus musculus (Mouse) TR34402_c4_g3_i4 Q1RK13 Y220_RICBR 7.00E-12 IPR002110; IPR020683; Putative ankyrin repeat protein RBE_0220 RBE_0220 Rickettsia bellii (strain RML369-C) TR34402_c4_g3_i5 Q7T163 KDIS_DANRE 2.00E-14 GO:0016021; GO:0005770; GO:0007399 integral to membrane; late endosome; nervous system development IPR002110; IPR020683; IPR011646; Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) kidins220 arms kidins220b si:dkeyp-7f8.3 si:dz119j18.2 zgc:63531 Danio rerio (Zebrafish) (Brachydanio rerio) TR34403_c1_g2_i1 Q566U4 KFA_DANRE 6.00E-89 GO:0034354; GO:0004061; GO:0005829; GO:0005634; GO:0019441 'de novo' NAD biosynthetic process from tryptophan; arylformamidase activity; cytosol; nucleus; tryptophan catabolic process to kynurenine IPR013094; IPR027519; Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. Kynurenine formamidase (KFA) (KFase) (EC 3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF) afmid zgc:112472 Danio rerio (Zebrafish) (Brachydanio rerio) TR34404_c0_g1_i1 P48052 CBPA2_HUMAN 6.00E-88 GO:0005576; GO:0004181; GO:0006508; GO:0007039; GO:0008270 extracellular region; metallocarboxypeptidase activity; proteolysis; vacuolar protein catabolic process; zinc ion binding IPR000834; IPR003146; IPR009020; Carboxypeptidase A2 (EC 3.4.17.15) CPA2 Homo sapiens (Human) TR34404_c0_g1_i2 Q4X1U0 ECM14_ASPFU 1.00E-25 GO:0004181; GO:0006508; GO:0005773; GO:0008270 metallocarboxypeptidase activity; proteolysis; vacuole; zinc ion binding IPR000834; IPR003146; IPR009020; Putative metallocarboxypeptidase ecm14 (EC 3.4.17.-) ecm14 AFUA_2G08790 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) TR34406_c1_g1_i1 Q9Y2L1 RRP44_HUMAN 3.00E-160 GO:0000175; GO:0071034; GO:0003723; GO:0005829; GO:0004519; GO:0043928; GO:0005085; GO:0000176; GO:0005654; GO:0016075; GO:0006364 Q01780; Q9NQT5 3'-5'-exoribonuclease activity; CUT catabolic process; RNA binding; cytosol; endonuclease activity; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; guanyl-nucleotide exchange factor activity; nuclear exosome (RNase complex); nucleoplasm; rRNA catabolic process; rRNA processing IPR012340; IPR002716; IPR022966; Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44) DIS3 KIAA1008 RRP44 Homo sapiens (Human) TR34406_c1_g1_i3 D0Z8E6 RNB_EDWTE 1.00E-16 GO:0003723; GO:0005737; GO:0008859; GO:0006402; GO:0090305 RNA binding; cytoplasm; exoribonuclease II activity; mRNA catabolic process; nucleic acid phosphodiester bond hydrolysis IPR011129; IPR012340; IPR003029; IPR022967; IPR013223; IPR011804; IPR022966; IPR004476; Exoribonuclease 2 (EC 3.1.13.1) (Exoribonuclease II) (RNase II) (Ribonuclease II) rnb ETAE_1878 Edwardsiella tarda (strain EIB202) TR34406_c1_g1_i4 Q8C0S1 DI3L1_MOUSE 0 GO:0000175; GO:0003723; GO:0000177; GO:0016075 3'-5'-exoribonuclease activity; RNA binding; cytoplasmic exosome (RNase complex); rRNA catabolic process IPR012340; IPR022966; DIS3-like exonuclease 1 (EC 3.1.13.-) Dis3l Kiaa1955 Mus musculus (Mouse) TR34407_c0_g1_i1 Q9NXS3 KLH28_HUMAN 2.00E-15 IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR015916; IPR017096; IPR006652; Kelch-like protein 28 (BTB/POZ domain-containing protein 5) KLHL28 BTBD5 Homo sapiens (Human) TR34407_c0_g1_i2 Q91XA8 KLD8A_MOUSE 6.00E-48 IPR015916; IPR015915; IPR006652; Kelch domain-containing protein 8A Klhdc8a Mus musculus (Mouse) TR34407_c0_g2_i1 Q6DFU2 NS1BP_XENLA 2.00E-06 GO:0005737; GO:0005856; GO:0005634 cytoplasm; cytoskeleton; nucleus IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Influenza virus NS1A-binding protein homolog (NS1-BP) (NS1-binding protein homolog) ivns1abp Xenopus laevis (African clawed frog) TR34407_c0_g2_i2 Q5XIA9 KLD8B_RAT 6.00E-18 GO:0005737 cytoplasm IPR015915; IPR006652; Kelch domain-containing protein 8B Klhdc8b Rattus norvegicus (Rat) TR34408_c1_g2_i1 Q9Z336 DYLT1_RAT 4.00E-67 GO:0005794; GO:0051301; GO:0005868; GO:0000132; GO:0006886; GO:0019060; GO:0005874; GO:0007067; GO:0003774; GO:0050768; GO:0048812; GO:0008277; GO:0032314; GO:0051493; GO:0005819 Q62968 Golgi apparatus; cell division; cytoplasmic dynein complex; establishment of mitotic spindle orientation; intracellular protein transport; intracellular transport of viral proteins in host cell; microtubule; mitosis; motor activity; negative regulation of neurogenesis; neuron projection morphogenesis; regulation of G-protein coupled receptor protein signaling pathway; regulation of Rac GTPase activity; regulation of cytoskeleton organization; spindle IPR005334; Dynein light chain Tctex-type 1 (Activator of G-protein signaling 2) (AGS2) (T-complex testis-specific protein 1 homolog) Dynlt1 Tctel1 Tctex-1 Tctex1 Rattus norvegicus (Rat) TR34409_c3_g1_i1 Q3ZBG9 PLS2_BOVIN 8.00E-72 GO:0016021; GO:0046872 integral to membrane; metal ion binding IPR005552; Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) TR34409_c3_g1_i5 Q3ZBG9 PLS2_BOVIN 1.00E-70 GO:0016021; GO:0046872 integral to membrane; metal ion binding IPR005552; Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) TR34410_c0_g1_i1 Q07973 CP24A_HUMAN 3.00E-33 GO:0030342; GO:0008403; GO:0020037; GO:0005506; GO:0005743; GO:0004497; GO:0001649; GO:0016705; GO:0042369; GO:0070561; GO:0006805 "1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; heme binding; iron ion binding; mitochondrial inner membrane; monooxygenase activity; osteoblast differentiation; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; vitamin D catabolic process; vitamin D receptor signaling pathway; xenobiotic metabolic process" IPR001128; IPR017972; IPR002401; "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.13.126) (Cytochrome P450 24A1) (Cytochrome P450-CC24)" CYP24A1 CYP24 Homo sapiens (Human) TR34410_c0_g1_i3 P30099 C11B2_RAT 6.00E-13 GO:0032342; GO:0071260; GO:0031670; GO:0071375; GO:0051365; GO:0047783; GO:0030425; GO:0006704; GO:0020037; GO:0005506; GO:0031966; GO:0045777; GO:0042493; GO:0032868; GO:0009651; GO:0004507 aldosterone biosynthetic process; cellular response to mechanical stimulus; cellular response to nutrient; cellular response to peptide hormone stimulus; cellular response to potassium ion starvation; corticosterone 18-monooxygenase activity; dendrite; glucocorticoid biosynthetic process; heme binding; iron ion binding; mitochondrial membrane; positive regulation of blood pressure; response to drug; response to insulin stimulus; response to salt stress; steroid 11-beta-monooxygenase activity IPR001128; IPR017972; IPR002399; "Cytochrome P450 11B2, mitochondrial (Aldosterone synthase) (CYPXIB2) (Cytochrome P450-Aldo-1) (Steroid 11-beta-hydroxylase) (EC 1.14.15.4) (EC 1.14.15.5)" Cyp11b2 Cyp11b-2 Rattus norvegicus (Rat) TR34411_c1_g1_i1 Q9D1B9 RM28_MOUSE 3.00E-42 GO:0005761; GO:0003735; GO:0006412 mitochondrial ribosome; structural constituent of ribosome; translation IPR026569; IPR001383; "39S ribosomal protein L28, mitochondrial (L28mt) (MRP-L28)" Mrpl28 Mus musculus (Mouse) TR34411_c1_g1_i2 Q68EV6 RM28_XENLA 4.00E-35 GO:0005739; GO:0005840; GO:0003735; GO:0006412 mitochondrion; ribosome; structural constituent of ribosome; translation IPR026569; IPR001383; "39S ribosomal protein L28, mitochondrial (L28mt) (MRP-L28)" mrpl28 Xenopus laevis (African clawed frog) TR34412_c5_g3_i1 P27674 GTR1_BOVIN 2.00E-146 GO:0030864; GO:0070837; GO:0046323; GO:0005355; GO:0005887; GO:0042470; GO:0030496; GO:0006461; GO:0043621 cortical actin cytoskeleton; dehydroascorbic acid transport; glucose import; glucose transmembrane transporter activity; integral to plasma membrane; melanosome; midbody; protein complex assembly; protein self-association IPR002439; IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1)" SLC2A1 GLUT-I GLUT1 Bos taurus (Bovine) TR34412_c5_g3_i2 P11168 GTR2_HUMAN 2.00E-115 GO:0055056; GO:0005903; GO:0005975; GO:0005737; GO:0033300; GO:0031018; GO:0006112; GO:0005355; GO:0005887; GO:0050796; GO:0044281 D-glucose transmembrane transporter activity; brush border; carbohydrate metabolic process; cytoplasm; dehydroascorbic acid transporter activity; endocrine pancreas development; energy reserve metabolic process; glucose transmembrane transporter activity; integral to plasma membrane; regulation of insulin secretion; small molecule metabolic process IPR002440; IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 2 (Glucose transporter type 2, liver) (GLUT-2)" SLC2A2 GLUT2 Homo sapiens (Human) TR34412_c5_g3_i3 P27674 GTR1_BOVIN 1.00E-146 GO:0030864; GO:0070837; GO:0046323; GO:0005355; GO:0005887; GO:0042470; GO:0030496; GO:0006461; GO:0043621 cortical actin cytoskeleton; dehydroascorbic acid transport; glucose import; glucose transmembrane transporter activity; integral to plasma membrane; melanosome; midbody; protein complex assembly; protein self-association IPR002439; IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1)" SLC2A1 GLUT-I GLUT1 Bos taurus (Bovine) TR34412_c5_g3_i5 Q56ZZ7 PLST4_ARATH 2.00E-58 GO:0008643; GO:0009941; GO:0009706; GO:0016021; GO:0022891 carbohydrate transport; chloroplast envelope; chloroplast inner membrane; integral to membrane; substrate-specific transmembrane transporter activity IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; Plastidic glucose transporter 4 (AtpGlcT) At5g16150 T21H19.70 Arabidopsis thaliana (Mouse-ear cress) TR34413_c0_g1_i2 Q5XGY9 MND1_XENLA 7.00E-78 GO:0006310; GO:0007126; GO:0005634 DNA recombination; meiosis; nucleus IPR005647; Meiotic nuclear division protein 1 homolog mnd1 Xenopus laevis (African clawed frog) TR34413_c0_g1_i3 Q5XGY9 MND1_XENLA 4.00E-78 GO:0006310; GO:0007126; GO:0005634 DNA recombination; meiosis; nucleus IPR005647; Meiotic nuclear division protein 1 homolog mnd1 Xenopus laevis (African clawed frog) TR34419_c1_g1_i1 O70279 DGC14_MOUSE 2.00E-48 GO:0008380; GO:0071013; GO:0006397; GO:0007399; GO:0005634 RNA splicing; catalytic step 2 spliceosome; mRNA processing; nervous system development; nucleus IPR019148; Protein DGCR14 (DiGeorge syndrome critical region 14 homolog) (ES2 protein) (Expressed sequence 2 embryonic lethal) Dgcr14 Dgsi Es2 Es2el Mus musculus (Mouse) TR34419_c1_g4_i1 O44424 DGC14_DROME 1.00E-08 GO:0071013; GO:0000398; GO:0007399 "catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nervous system development" IPR019148; Protein DGCR14 homolog (Protein Es2) (dEs2) Es2 CG1474 Drosophila melanogaster (Fruit fly) TR34420_c1_g1_i2 Q8ITC3 RS19_AEQIR 4.00E-72 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001266; IPR018277; IPR011991; 40S ribosomal protein S19 RPS19 Argopecten irradians (Bay scallop) (Aequipecten irradians) TR34422_c5_g1_i1 Q8TDB6 DTX3L_HUMAN 5.00E-45 GO:0005737; GO:0006302; GO:0042393; GO:0010390; GO:0005634; GO:0004842; GO:0008270 cytoplasm; double-strand break repair; histone binding; histone monoubiquitination; nucleus; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) TR34422_c6_g1_i1 Q9BTY2 FUCO2_HUMAN 4.00E-179 GO:0004560; GO:0005576; GO:0042806; GO:0006004; GO:0005764 alpha-L-fucosidase activity; extracellular region; fucose binding; fucose metabolic process; lysosome IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2) FUCA2 PSEC0151 UNQ227/PRO260 Homo sapiens (Human) TR34422_c6_g1_i3 P49713 FUCO_CAEEL 9.00E-131 GO:0004560; GO:0042806; GO:0006004; GO:0005764 alpha-L-fucosidase activity; fucose binding; fucose metabolic process; lysosome IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Putative alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) W03G11.3 Caenorhabditis elegans TR34422_c6_g1_i4 P10901 FUCO_DICDI 1.00E-109 GO:0033938; GO:0005576; GO:0042806; GO:0006004; GO:0005764 "1,6-alpha-L-fucosidase activity; extracellular region; fucose binding; fucose metabolic process; lysosome" IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) alfA DDB_G0274391 Dictyostelium discoideum (Slime mold) TR34422_c6_g1_i5 P04066 FUCO_HUMAN 3.00E-166 GO:0004560; GO:0042806; GO:0006004; GO:0006027; GO:0005764 alpha-L-fucosidase activity; fucose binding; fucose metabolic process; glycosaminoglycan catabolic process; lysosome IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) FUCA1 Nbla10230 Homo sapiens (Human) TR34422_c6_g1_i8 Q9BTY2 FUCO2_HUMAN 0 GO:0004560; GO:0005576; GO:0042806; GO:0006004; GO:0005764 alpha-L-fucosidase activity; extracellular region; fucose binding; fucose metabolic process; lysosome IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2) FUCA2 PSEC0151 UNQ227/PRO260 Homo sapiens (Human) TR34422_c7_g1_i1 Q97UU4 Y2899_SULSO 1.00E-17 IPR002589; Uncharacterized protein SSO2899 SSO2899 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) TR34423_c4_g2_i1 Q8VBX4 CLC4K_MOUSE 3.00E-12 GO:0030246; GO:0051607; GO:0005887 carbohydrate binding; defense response to virus; integral to plasma membrane IPR001304; IPR016186; IPR018378; IPR016187; C-type lectin domain family 4 member K (Langerin) (CD antigen CD207) Cd207 Clec4k Mus musculus (Mouse) TR34423_c4_g2_i2 P02707 LECH_CHICK 1.00E-14 GO:0030246; GO:0006897; GO:0016021 carbohydrate binding; endocytosis; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; Hepatic lectin Gallus gallus (Chicken) TR34423_c4_g2_i3 Q91ZW7 C209E_MOUSE 2.00E-13 GO:0006897; GO:0016021; GO:0005537 endocytosis; integral to membrane; mannose binding IPR001304; IPR016186; IPR018378; IPR016187; CD209 antigen-like protein E (DC-SIGN-related protein 4) (DC-SIGNR4) (CD antigen CD209) Cd209e Mus musculus (Mouse) TR34425_c0_g1_i2 Q61010 DTX1_MOUSE 7.00E-06 GO:0007219; GO:0005829; GO:0010001; GO:0016874; GO:0045581; GO:0045665; GO:0005634; GO:0016567; GO:0008593; GO:0008270 Notch signaling pathway; cytosol; glial cell differentiation; ligase activity; negative regulation of T cell differentiation; negative regulation of neuron differentiation; nucleus; protein ubiquitination; regulation of Notch signaling pathway; zinc ion binding IPR004170; IPR018123; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DTX1 (EC 6.3.2.-) (FXI-T1) (Protein deltex-1) (Deltex1) (mDTX1) Dtx1 Mus musculus (Mouse) TR34425_c1_g1_i2 O88554 PARP2_MOUSE 0 GO:0003677; GO:0003950; GO:0006284; GO:0097191; GO:0005730; GO:0005654; GO:0006471 DNA binding; NAD+ ADP-ribosyltransferase activity; base-excision repair; extrinsic apoptotic signaling pathway; nucleolus; nucleoplasm; protein ADP-ribosylation IPR012317; IPR004102; IPR008893; Poly [ADP-ribose] polymerase 2 (PARP-2) (mPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) Parp2 Adprt2 Adprtl2 Aspartl2 Mus musculus (Mouse) TR34425_c1_g1_i3 O88554 PARP2_MOUSE 0 GO:0003677; GO:0003950; GO:0006284; GO:0097191; GO:0005730; GO:0005654; GO:0006471 DNA binding; NAD+ ADP-ribosyltransferase activity; base-excision repair; extrinsic apoptotic signaling pathway; nucleolus; nucleoplasm; protein ADP-ribosylation IPR012317; IPR004102; IPR008893; Poly [ADP-ribose] polymerase 2 (PARP-2) (mPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) Parp2 Adprt2 Adprtl2 Aspartl2 Mus musculus (Mouse) TR34426_c0_g2_i2 O61213 DUOX1_CAEEL 1.00E-22 GO:0016174; GO:0005509; GO:0042338; GO:0020037; GO:0042744; GO:0016021; GO:0002119; GO:0018149; GO:0004601; GO:0040032; GO:0006979 NAD(P)H oxidase activity; calcium ion binding; cuticle development involved in collagen and cuticulin-based cuticle molting cycle; heme binding; hydrogen peroxide catabolic process; integral to membrane; nematode larval development; peptide cross-linking; peroxidase activity; post-embryonic body morphogenesis; response to oxidative stress IPR011992; IPR002048; IPR013112; IPR017927; IPR013130; IPR013121; IPR010255; IPR002007; IPR019791; IPR017938; Dual oxidase 1 (DUOX1) (EC 1.11.1.-) (EC 1.6.3.1) (Blistered cuticle protein 3) (NADPH thyroid oxidase 1) bli-3 F56C11.1 Caenorhabditis elegans TR34426_c0_g2_i3 Q7QH73 PERC_ANOGA 1.00E-93 GO:0005576; GO:0020037; GO:0042744; GO:0046872; GO:0004601 extracellular region; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity IPR010255; IPR002007; IPR019791; Chorion peroxidase (EC 1.11.1.7) pxt AGAP004038 Anopheles gambiae (African malaria mosquito) TR34429_c0_g1_i4 O34918 YOAJ_BACSU 8.00E-08 GO:0005618; GO:0005576 cell wall; extracellular region IPR014733; IPR007117; IPR009009; Expansin-YoaJ (EXLX1) yoaJ BSU18630 Bacillus subtilis (strain 168) TR34432_c0_g1_i1 P17694 NDUS2_BOVIN 0 GO:0051539; GO:0051287; GO:0008137; GO:0046872; GO:0005747; GO:0048038; GO:0006979 "4 iron, 4 sulfur cluster binding; NAD binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; mitochondrial respiratory chain complex I; quinone binding; response to oxidative stress" IPR001135; IPR014029; IPR022885; "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-49kD) (CI-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit)" NDUFS2 Bos taurus (Bovine) TR34433_c0_g1_i2 Q9QZS7 NPHN_MOUSE 2.00E-08 GO:0007254; GO:0007155; GO:0042995; GO:0032836; GO:0072015; GO:0005887; GO:0007520; GO:0030838; GO:0044062; GO:0007519; GO:0036057 JNK cascade; cell adhesion; cell projection; glomerular basement membrane development; glomerular visceral epithelial cell development; integral to plasma membrane; myoblast fusion; positive regulation of actin filament polymerization; regulation of excretion; skeletal muscle tissue development; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Mus musculus (Mouse) TR34434_c0_g1_i1 P32986 YBP2_ACIAM 4.00E-33 GO:0016799 "hydrolase activity, hydrolyzing N-glycosyl compounds" IPR015910; IPR023186; IPR001910; Uncharacterized protein in bps2 5'region (ORF2) (Fragment) Acidianus ambivalens (Desulfurolobus ambivalens) TR34434_c0_g1_i4 Q27546 IUNH_CRIFA 6.00E-39 GO:0016799; GO:0046872; GO:0009117 "hydrolase activity, hydrolyzing N-glycosyl compounds; metal ion binding; nucleotide metabolic process" IPR015910; IPR023186; IPR001910; Purine metabolism; purine nucleoside salvage. Inosine-uridine preferring nucleoside hydrolase (IU-NH) (IU-nucleoside hydrolase) (EC 3.2.2.-) (Non-specific nucleoside hydrolase) (Purine nucleosidase) IUNH Crithidia fasciculata TR34434_c1_g1_i1 Q9P6J4 YHD6_SCHPO 8.00E-14 GO:0034356; GO:0005829; GO:0070635; GO:0019358; GO:0070636; GO:0005634; GO:0046135; GO:0008655; GO:0045437 NAD biosynthesis via nicotinamide riboside salvage pathway; cytosol; nicotinamide riboside hydrolase activity; nicotinate nucleotide salvage; nicotinic acid riboside hydrolase activity; nucleus; pyrimidine nucleoside catabolic process; pyrimidine-containing compound salvage; uridine nucleosidase activity IPR023186; IPR001910; Uncharacterized protein C1683.06c SPBC1683.06c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR34437_c0_g2_i1 Q6DFC8 ZN395_XENLA 5.00E-39 GO:0003677; GO:0005737; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cytoplasm; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; Zinc finger protein 395 znf395 Xenopus laevis (African clawed frog) TR34437_c0_g2_i3 Q9NR83 S2A4R_HUMAN 7.00E-12 GO:0003677; GO:0005737; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; cytoplasm; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; SLC2A4 regulator (GLUT4 enhancer factor) (GEF) (Huntington disease gene regulatory region-binding protein 1) (HDBP-1) SLC2A4RG HDBP1 Homo sapiens (Human) TR34438_c0_g1_i1 O02768 PGH2_RABIT 0 GO:0042640; GO:0050873; GO:0071456; GO:0019371; GO:0005737; GO:0051213; GO:0005789; GO:0020037; GO:0046872; GO:0043005; GO:0005634; GO:0004601; GO:0090336; GO:0031622; GO:0004666; GO:0008217; GO:0042127; GO:0006979 anagen; brown fat cell differentiation; cellular response to hypoxia; cyclooxygenase pathway; cytoplasm; dioxygenase activity; endoplasmic reticulum membrane; heme binding; metal ion binding; neuron projection; nucleus; peroxidase activity; positive regulation of brown fat cell differentiation; positive regulation of fever generation; prostaglandin-endoperoxide synthase activity; regulation of blood pressure; regulation of cell proliferation; response to oxidative stress IPR000742; IPR010255; IPR002007; IPR019791; Lipid metabolism; prostaglandin biosynthesis. Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) PTGS2 COX-2 COX2 Oryctolagus cuniculus (Rabbit) TR34438_c0_g1_i3 O62664 PGH1_BOVIN 0 GO:0019371; GO:0051213; GO:0005789; GO:0020037; GO:0046872; GO:0004601; GO:0001750; GO:0004666; GO:0008217; GO:0042127; GO:0006979 cyclooxygenase pathway; dioxygenase activity; endoplasmic reticulum membrane; heme binding; metal ion binding; peroxidase activity; photoreceptor outer segment; prostaglandin-endoperoxide synthase activity; regulation of blood pressure; regulation of cell proliferation; response to oxidative stress IPR000742; IPR010255; IPR002007; IPR019791; Lipid metabolism; prostaglandin biosynthesis. Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1) PTGS1 COX-1 COX1 Bos taurus (Bovine) TR34438_c0_g1_i4 Q9P2S2 NRX2A_HUMAN 5.00E-06 GO:0005246; GO:0007155; GO:0050839; GO:0097116; GO:0016021; GO:0046872; GO:0097118; GO:0097109; GO:0007269; GO:0097119; GO:0097104 calcium channel regulator activity; cell adhesion; cell adhesion molecule binding; gephyrin clustering; integral to membrane; metal ion binding; neuroligin clustering; neuroligin family protein binding; neurotransmitter secretion; postsynaptic density protein 95 clustering; postsynaptic membrane assembly IPR008985; IPR013320; IPR000742; IPR001791; IPR003585; IPR027160; IPR027789; Neurexin-2 (Neurexin II-alpha) (Neurexin-2-alpha) NRXN2 KIAA0921 Homo sapiens (Human) TR3444_c0_g1_i1 P15153 RAC2_HUMAN 1.00E-80 GO:0005525; GO:0003924; GO:0030036; GO:0007411; GO:0045453; GO:0030031; GO:0005829; GO:0005635; GO:0005886; GO:0030168; GO:0008284; GO:0010310; GO:0060263; GO:0051056; GO:0007264 GTP binding; GTPase activity; actin cytoskeleton organization; axon guidance; bone resorption; cell projection assembly; cytosol; nuclear envelope; plasma membrane; platelet activation; positive regulation of cell proliferation; regulation of hydrogen peroxide metabolic process; regulation of respiratory burst; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2) RAC2 Homo sapiens (Human) TR34440_c0_g1_i1 P54411 TCPE2_AVESA 2.00E-73 GO:0005524; GO:0005737; GO:0006457 ATP binding; cytoplasm; protein folding IPR012718; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon) (TCP-K36) Avena sativa (Oat) TR34440_c0_g1_i2 Q54ER7 TCPH_DICDI 0 GO:0005524; GO:0005832; GO:0006457; GO:0051082 ATP binding; chaperonin-containing T-complex; protein folding; unfolded protein binding IPR012720; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) cct7 DDB_G0291225 Dictyostelium discoideum (Slime mold) TR34440_c0_g1_i3 Q5ZJK8 TCPH_CHICK 0 GO:0005524; GO:0007339; GO:0005832; GO:0005874; GO:0005739; GO:0006457; GO:0002199 ATP binding; binding of sperm to zona pellucida; chaperonin-containing T-complex; microtubule; mitochondrion; protein folding; zona pellucida receptor complex IPR012720; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) CCT7 RCJMB04_17g3 Gallus gallus (Chicken) TR34441_c0_g1_i1 Q54KA7 SECG_DICDI 4.00E-18 GO:0005086; GO:0031589; GO:0006935; GO:0005829; GO:0005764; GO:0005543; GO:0032012 ARF guanyl-nucleotide exchange factor activity; cell-substrate adhesion; chemotaxis; cytosol; lysosome; phospholipid binding; regulation of ARF protein signal transduction IPR002110; IPR020683; IPR011993; IPR001849; IPR023394; IPR000904; "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) TR34441_c0_g1_i2 Q91ZT9 ASB8_MOUSE 3.00E-16 GO:0005737; GO:0035556; GO:0016567 cytoplasm; intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 8 (ASB-8) Asb8 Mus musculus (Mouse) TR34444_c0_g1_i1 Q06HQ7 PLB1_MONDO 5.00E-82 GO:0016324; GO:0016021; GO:0016042; GO:0004622; GO:0004623 apical plasma membrane; integral to membrane; lipid catabolic process; lysophospholipase activity; phospholipase A2 activity IPR001087; IPR008265; IPR013831; "Phospholipase B1, membrane-associated (Phospholipase B) (Phospholipase B/lipase) (PLB/LIP) [Includes: Phospholipase A2 (EC 3.1.1.4); Lysophospholipase (EC 3.1.1.5)]" PLB1 PLB Monodelphis domestica (Gray short-tailed opossum) TR34446_c0_g1_i1 P34275 IVD_CAEEL 1.00E-42 GO:0003995; GO:0050660; GO:0006552 acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; leucine catabolic process IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3. Probable acyl-CoA dehydrogenase 6 (Probable isovaleryl-CoA dehydrogenase) (IVD) (EC 1.3.8.4) acdh-6 C02D5.1 Caenorhabditis elegans TR34446_c0_g1_i2 Q8X1D8 NAO_FUSOX 4.00E-12 GO:0071949; GO:0052664; GO:0050141; GO:0006807; GO:0016627 "FAD binding; nitroalkane oxidase activity; nitroethane oxidase activity; nitrogen compound metabolic process; oxidoreductase activity, acting on the CH-CH group of donors" IPR006091; IPR009075; IPR013786; IPR009100; Nitroalkane oxidase (NAO) (EC 1.7.3.1) Fusarium oxysporum (Fusarium vascular wilt) TR34446_c0_g1_i4 Q9JHI5 IVD_MOUSE 0 GO:0050660; GO:0008470; GO:0006552; GO:0005759; GO:0031966; GO:0005739 flavin adenine dinucleotide binding; isovaleryl-CoA dehydrogenase activity; leucine catabolic process; mitochondrial matrix; mitochondrial membrane; mitochondrion IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3. "Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) (EC 1.3.8.4)" Ivd Mus musculus (Mouse) TR34446_c0_g1_i5 Q5RBD5 IVD_PONAB 2.00E-144 GO:0003995; GO:0050660; GO:0006552; GO:0005759 acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; leucine catabolic process; mitochondrial matrix IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3. "Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) (EC 1.3.8.4)" IVD Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34447_c0_g2_i2 Q5M8Y1 SPCS2_XENTR 1.00E-70 GO:0016021; GO:0008233; GO:0006508; GO:0005787; GO:0006465 integral to membrane; peptidase activity; proteolysis; signal peptidase complex; signal peptide processing IPR009582; Probable signal peptidase complex subunit 2 (EC 3.4.-.-) (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit) spcs2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34447_c0_g2_i3 Q9VYY2 SPCS2_DROME 4.00E-36 GO:0016021; GO:0008233; GO:0006508; GO:0005787; GO:0006465 integral to membrane; peptidase activity; proteolysis; signal peptidase complex; signal peptide processing IPR009582; Signal peptidase complex subunit 2 (EC 3.4.-.-) (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit) Spase25 CG1751 Drosophila melanogaster (Fruit fly) TR34447_c0_g2_i5 P58684 SPCS2_ARATH 4.00E-09 GO:0005783; GO:0016021; GO:0008233; GO:0006508; GO:0005787; GO:0006465 endoplasmic reticulum; integral to membrane; peptidase activity; proteolysis; signal peptidase complex; signal peptide processing IPR009582; Probable signal peptidase complex subunit 2 (EC 3.4.-.-) (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit) At2g39960 T28M21.12 Arabidopsis thaliana (Mouse-ear cress) TR34447_c0_g2_i7 Q9XWW1 SPCS2_CAEEL 5.00E-35 GO:0016021; GO:0008233; GO:0006508; GO:0016529; GO:0005787; GO:0006465 Q18516 integral to membrane; peptidase activity; proteolysis; sarcoplasmic reticulum; signal peptidase complex; signal peptide processing IPR009582; Probable signal peptidase complex subunit 2 (EC 3.4.-.-) (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit) Y37D8A.10 Caenorhabditis elegans TR34447_c0_g2_i8 Q9VYY2 SPCS2_DROME 4.00E-36 GO:0016021; GO:0008233; GO:0006508; GO:0005787; GO:0006465 integral to membrane; peptidase activity; proteolysis; signal peptidase complex; signal peptide processing IPR009582; Signal peptidase complex subunit 2 (EC 3.4.-.-) (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit) Spase25 CG1751 Drosophila melanogaster (Fruit fly) TR34447_c0_g2_i9 Q5M8Y1 SPCS2_XENTR 1.00E-70 GO:0016021; GO:0008233; GO:0006508; GO:0005787; GO:0006465 integral to membrane; peptidase activity; proteolysis; signal peptidase complex; signal peptide processing IPR009582; Probable signal peptidase complex subunit 2 (EC 3.4.-.-) (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit) spcs2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34448_c0_g1_i1 Q3UMW8 CLN5_MOUSE 5.00E-92 GO:0005794; GO:0007420; GO:0008219; GO:0005783; GO:0070085; GO:0016021; GO:0007042; GO:0005765; GO:0005537; GO:0022008; GO:0048471; GO:0006465; GO:0005775; GO:0007601 Golgi apparatus; brain development; cell death; endoplasmic reticulum; glycosylation; integral to membrane; lysosomal lumen acidification; lysosomal membrane; mannose binding; neurogenesis; perinuclear region of cytoplasm; signal peptide processing; vacuolar lumen; visual perception IPR026138; Ceroid-lipofuscinosis neuronal protein 5 homolog (Protein CLN5) Cln5 Mus musculus (Mouse) TR34448_c0_g1_i2 Q28HC7 COMD6_XENTR 3.00E-28 GO:0005737; GO:0005634 cytoplasm; nucleus IPR017920; IPR009886; COMM domain-containing protein 6 commd6 TEgg014m16.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34448_c0_g1_i3 Q3UMW8 CLN5_MOUSE 8.00E-93 GO:0005794; GO:0007420; GO:0008219; GO:0005783; GO:0070085; GO:0016021; GO:0007042; GO:0005765; GO:0005537; GO:0022008; GO:0048471; GO:0006465; GO:0005775; GO:0007601 Golgi apparatus; brain development; cell death; endoplasmic reticulum; glycosylation; integral to membrane; lysosomal lumen acidification; lysosomal membrane; mannose binding; neurogenesis; perinuclear region of cytoplasm; signal peptide processing; vacuolar lumen; visual perception IPR026138; Ceroid-lipofuscinosis neuronal protein 5 homolog (Protein CLN5) Cln5 Mus musculus (Mouse) TR34449_c0_g1_i2 O75581 LRP6_HUMAN 3.00E-19 GO:0044332; GO:0021874; GO:0090244; GO:0042813; GO:0034185; GO:0090245; GO:0060349; GO:0046849; GO:0060444; GO:0061310; GO:0044335; GO:0061324; GO:0044340; GO:0042074; GO:0009986; GO:0071397; GO:0021587; GO:0021795; GO:0021987; GO:0060026; GO:0071936; GO:0031410; GO:0071542; GO:0005769; GO:0048596; GO:0042733; GO:0035115; GO:0035116; GO:0030326; GO:0009880; GO:0060059; GO:0005783; GO:0035261; GO:0060325; GO:0021861; GO:0021943; GO:0001947; GO:0016021; GO:0019210; GO:0005041; GO:0060596; GO:0030901; GO:0030917; GO:0050680; GO:0045599; GO:2000151; GO:2000162; GO:2000168; GO:2000164; GO:2000166; GO:2000149; GO:0071901; GO:0034392; GO:0014029; GO:0001843; GO:0043025; GO:0042475; GO:0060021; GO:0003344; GO:0005886; GO:2000055; GO:0043065; GO:0045780; GO:0090263; GO:0045787; GO:0002053; GO:0045778; GO:0051091; GO:0045944; GO:0036342; GO:0090009; GO:0043235; GO:0090118; GO:0060284; GO:0045598; GO:0030278; GO:0051593; GO:0045202; GO:0007268; GO:0021794; GO:0019534; GO:0060535 Q9Y4X0; Q9H6X2; O70239; Q03135; P98082; P49840; P49841; Q5S007; Q9ERE8 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt receptor signaling pathway involved in forebrain neuroblast division; Wnt receptor signaling pathway involved in somitogenesis; Wnt-activated receptor activity; apolipoprotein binding; axis elongation involved in somitogenesis; bone morphogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development; canonical Wnt receptor signaling pathway involved in neural crest cell differentiation; canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; canonical Wnt receptor signaling pathway involved in regulation of cell proliferation; cell migration involved in gastrulation; cell surface; cellular response to cholesterol; cerebellum morphogenesis; cerebral cortex cell migration; cerebral cortex development; convergent extension; coreceptor activity involved in Wnt receptor signaling pathway; cytoplasmic vesicle; dopaminergic neuron differentiation; early endosome; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; embryonic pattern specification; embryonic retina morphogenesis in camera-type eye; endoplasmic reticulum; external genitalia morphogenesis; face morphogenesis; forebrain radial glial cell differentiation; formation of radial glial scaffolds; heart looping; integral to membrane; kinase inhibitor activity; low-density lipoprotein receptor activity; mammary placode formation; midbrain development; midbrain-hindbrain boundary development; negative regulation of epithelial cell proliferation; negative regulation of fat cell differentiation; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis; negative regulation of planar cell polarity pathway involved in neural tube closure; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest formation; neural tube closure; neuronal cell body; odontogenesis of dentin-containing tooth; palate development; pericardium morphogenesis; plasma membrane; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell cycle; positive regulation of mesenchymal cell proliferation; positive regulation of ossification; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; post-anal tail morphogenesis; primitive streak formation; receptor complex; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport; regulation of cell development; regulation of fat cell differentiation; regulation of ossification; response to folic acid; synapse; synaptic transmission; thalamus development; toxin transporter activity; trachea cartilage morphogenesis IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 6 (LRP-6) LRP6 Homo sapiens (Human) TR34450_c1_g1_i3 Q91WU4 TMCO4_MOUSE 6.00E-138 GO:0016021 integral to membrane IPR007941; Transmembrane and coiled-coil domain-containing protein 4 Tmco4 Mus musculus (Mouse) TR34452_c0_g2_i1 Q8SVJ8 NOG1_ENCCU 8.00E-13 GO:0005525; GO:0005730; GO:0042254 GTP binding; nucleolus; ribosome biogenesis IPR006073; IPR010674; IPR012973; IPR027417; Nucleolar GTP-binding protein 1 NOG1 ECU05_0800 Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) TR34452_c0_g2_i2 Q5RDW1 GTPB5_PONAB 2.00E-94 GO:0005525; GO:0003924; GO:0000287; GO:0005743; GO:0005761; GO:0070129; GO:0044065; GO:0042254 GTP binding; GTPase activity; magnesium ion binding; mitochondrial inner membrane; mitochondrial ribosome; regulation of mitochondrial translation; regulation of respiratory system process; ribosome biogenesis IPR014100; IPR006169; IPR006073; IPR027417; IPR005225; Mitochondrial ribosome-associated GTPase 2 (GTP-binding protein 5) MTG2 GTPBP5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34454_c0_g2_i1 Q9D0C1 RN115_MOUSE 2.00E-53 GO:0005829; GO:0051865; GO:0004842; GO:0008270 cytosol; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF115 (EC 6.3.2.-) (RING finger protein 115) (Rabring 7) (Zinc finger protein 364) Rnf115 Zfp364 Znf364 Mus musculus (Mouse) TR34454_c0_g2_i3 Q9Y4L5 RN115_HUMAN 2.00E-51 GO:0005829; GO:0051865; GO:0004842; GO:0008270 cytosol; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF115 (EC 6.3.2.-) (RING finger protein 115) (Rabring 7) (Zinc finger protein 364) RNF115 ZNF364 Homo sapiens (Human) TR34455_c0_g1_i1 Q9DC61 MPPA_MOUSE 0 GO:0046872; GO:0004222; GO:0005759; GO:0005739; GO:0006508 metal ion binding; metalloendopeptidase activity; mitochondrial matrix; mitochondrion; proteolysis IPR011249; IPR011237; IPR011765; IPR001431; IPR007863; Mitochondrial-processing peptidase subunit alpha (EC 3.4.24.64) (Alpha-MPP) (P-55) Pmpca Inpp5e Mus musculus (Mouse) TR34458_c0_g1_i2 Q812A3 ANR23_MOUSE 1.00E-16 GO:0031674; GO:0015629; GO:0006631; GO:0005634 I band; actin cytoskeleton; fatty acid metabolic process; nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) Ankrd23 Darp Mus musculus (Mouse) TR34458_c0_g1_i3 Q99MQ3 PINK1_MOUSE 5.00E-10 GO:0005524; GO:0010857; GO:0097237; GO:0005829; GO:0016021; GO:0007243; GO:0000287; GO:0005741; GO:0005739; GO:0000422; GO:0043524; GO:0018105; GO:0043123; GO:0033603; GO:0090200; GO:0032226; GO:0004674; GO:0043254; GO:0031396; GO:0006950 "ATP binding; calcium-dependent protein kinase activity; cellular response to toxic substance; cytosol; integral to membrane; intracellular protein kinase cascade; magnesium ion binding; mitochondrial outer membrane; mitochondrion; mitochondrion degradation; negative regulation of neuron apoptotic process; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of dopamine secretion; positive regulation of release of cytochrome c from mitochondria; positive regulation of synaptic transmission, dopaminergic; protein serine/threonine kinase activity; regulation of protein complex assembly; regulation of protein ubiquitination; response to stress" IPR011009; IPR000719; IPR017441; IPR008271; "Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)" Pink1 Mus musculus (Mouse) TR34459_c1_g1_i4 C1BY38 CR032_ESOLU 1.00E-06 IPR026776; UPF0729 protein C18orf32 homolog Esox lucius (Northern pike) TR34464_c0_g1_i1 Q9H6P5 TASP1_HUMAN 2.00E-99 GO:0045893; GO:0006508; GO:0004298 "positive regulation of transcription, DNA-dependent; proteolysis; threonine-type endopeptidase activity" IPR000246; Threonine aspartase 1 (Taspase-1) (EC 3.4.25.-) [Cleaved into: Threonine aspartase subunit alpha; Threonine aspartase subunit beta] TASP1 C20orf13 Homo sapiens (Human) TR34464_c0_g1_i3 P30362 ASPG_LUPAR 1.00E-21 GO:0008798; GO:0006508 beta-aspartyl-peptidase activity; proteolysis IPR000246; Isoaspartyl peptidase/L-asparaginase (EC 3.4.19.5) (L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase subunit alpha; Isoaspartyl peptidase/L-asparaginase subunit beta] (Fragment) Lupinus arboreus (Tree lupin) TR34466_c3_g1_i1 P35440 TSP2_CHICK 2.00E-25 GO:0005604; GO:0005509; GO:0007155; GO:0008201; GO:0016525 basement membrane; calcium ion binding; cell adhesion; heparin binding; negative regulation of angiogenesis IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR024731; IPR001791; IPR000884; IPR015455; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-2 THBS2 TSP2 Gallus gallus (Chicken) TR34467_c2_g2_i1 Q91ZR3 ZHANG_MOUSE 1.00E-21 GO:0045814; GO:0045892; GO:0005634; GO:0051090; GO:0009615; GO:0043565; GO:0003700; GO:0006351 P62509 "negative regulation of gene expression, epigenetic; negative regulation of transcription, DNA-dependent; nucleus; regulation of sequence-specific DNA binding transcription factor activity; response to virus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei) (Tyrosine kinase-associated leucine zipper protein LAZip) Crebzf Zf Mus musculus (Mouse) TR34469_c3_g1_i3 Q6ZR37 PKHG7_HUMAN 1.00E-54 GO:0005089; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; phospholipid binding; regulation of Rho protein signal transduction IPR000219; IPR011993; IPR001849; Pleckstrin homology domain-containing family G member 7 (PH domain-containing family G member 7) PLEKHG7 Homo sapiens (Human) TR34469_c3_g1_i5 Q6ZR37 PKHG7_HUMAN 1.00E-19 GO:0005089; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; phospholipid binding; regulation of Rho protein signal transduction IPR000219; IPR011993; IPR001849; Pleckstrin homology domain-containing family G member 7 (PH domain-containing family G member 7) PLEKHG7 Homo sapiens (Human) TR34470_c0_g2_i1 Q8NBN7 RDH13_HUMAN 6.00E-48 GO:0005739; GO:0016491 mitochondrion; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Retinol dehydrogenase 13 (EC 1.1.1.-) RDH13 PSEC0082 UNQ736/PRO1430 Homo sapiens (Human) TR34472_c2_g1_i3 Q9VZW5 FMAR_DROME 2.00E-19 GO:0002209; GO:0007204; GO:0005887; GO:0008345; GO:0008188 behavioral defense response; elevation of cytosolic calcium ion concentration; integral to plasma membrane; larval locomotory behavior; neuropeptide receptor activity IPR000276; IPR017452; FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) TR34473_c2_g1_i2 O95786 DDX58_HUMAN 4.00E-74 GO:0005524; GO:0008026; GO:0039529; GO:0015629; GO:0005829; GO:0009597; GO:0003690; GO:0003725; GO:0045087; GO:0019048; GO:0032480; GO:0002230; GO:0032727; GO:0032728; GO:0051091; GO:0042993; GO:0045944; GO:0030334; GO:0034344; GO:0043330; GO:0032587; GO:0003727; GO:0005923; GO:0008270 Itself; P04543; Q920D5; Q9NQC7; O00571; Q7Z434; P21699; P04487; Q96S55; Q6IUF9; Q6IVU5; Q6UY62; Q6UY71; Q7Z2W4; Q7Z2W4-2 ATP binding; ATP-dependent helicase activity; RIG-I signaling pathway; actin cytoskeleton; cytosol; detection of virus; double-stranded DNA binding; double-stranded RNA binding; innate immune response; modulation by virus of host morphology or physiology; negative regulation of type I interferon production; positive regulation of defense response to virus by host; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of cell migration; regulation of type III interferon production; response to exogenous dsRNA; ruffle membrane; single-stranded RNA binding; tight junction; zinc ion binding IPR003593; IPR011029; IPR011545; IPR014001; IPR001650; IPR027417; IPR021673; Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) DDX58 Homo sapiens (Human) TR34473_c2_g1_i3 Q8LMR2 DCL1_ORYSJ 2.00E-09 GO:0005524; GO:0003723; GO:0004386; GO:0046872; GO:0007275; GO:0090305; GO:0005634; GO:0035196; GO:0004525 ATP binding; RNA binding; helicase activity; metal ion binding; multicellular organismal development; nucleic acid phosphodiester bond hydrolysis; nucleus; production of miRNAs involved in gene silencing by miRNA; ribonuclease III activity IPR005034; IPR014720; IPR014001; IPR001650; IPR027417; IPR003100; IPR000999; Endoribonuclease Dicer homolog 1 (Dicer-like protein 1) (OsDCL1) (EC 3.1.26.-) DCL1 Os03g0121800 LOC_Os03g02970 OJ1705B08.11 OsJ_09217 Oryza sativa subsp. japonica (Rice) TR34473_c2_g1_i5 Q69LX2 DCL2B_ORYSJ 3.00E-24 GO:0005524; GO:0008026; GO:0003723; GO:0006396; GO:0031047; GO:0046872; GO:0090305; GO:0005634; GO:0004525 ATP binding; ATP-dependent helicase activity; RNA binding; RNA processing; gene silencing by RNA; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleus; ribonuclease III activity IPR005034; IPR011545; IPR014720; IPR014001; IPR001650; IPR027417; IPR003100; IPR000999; Endoribonuclease Dicer homolog 2b (Dicer-like protein 2b) (OsDCL2b) (EC 3.1.26.-) DCL2B Os09g0315100 LOC_Os09g14610 OSJNBa0057D11.8-1 OSJNBb0079G12.35-1 Oryza sativa subsp. japonica (Rice) TR34473_c2_g1_i7 Q6Q899 DDX58_MOUSE 2.00E-47 GO:0005524; GO:0008026; GO:0039529; GO:0015629; GO:0005829; GO:0009597; GO:0003690; GO:0003725; GO:0045087; GO:0002230; GO:0032727; GO:0032728; GO:0042993; GO:0045944; GO:0030334; GO:0043330; GO:0009615; GO:0032587; GO:0003727; GO:0005923; GO:0008270 P22682; Q80ZE3 ATP binding; ATP-dependent helicase activity; RIG-I signaling pathway; actin cytoskeleton; cytosol; detection of virus; double-stranded DNA binding; double-stranded RNA binding; innate immune response; positive regulation of defense response to virus by host; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of cell migration; response to exogenous dsRNA; response to virus; ruffle membrane; single-stranded RNA binding; tight junction; zinc ion binding IPR011029; IPR011545; IPR014001; IPR001650; IPR027417; IPR021673; Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) TR34475_c0_g1_i1 O09174 AMACR_MOUSE 1.00E-132 GO:0008111; GO:0006699; GO:0006631; GO:0008300; GO:0005739; GO:0005777 alpha-methylacyl-CoA racemase activity; bile acid biosynthetic process; fatty acid metabolic process; isoprenoid catabolic process; mitochondrion; peroxisome IPR003673; IPR023606; Lipid metabolism; bile acid biosynthesis. Lipid metabolism; fatty acid metabolism. Alpha-methylacyl-CoA racemase (EC 5.1.99.4) (2-methylacyl-CoA racemase) Amacr Macr1 Mus musculus (Mouse) TR34476_c0_g1_i1 Q9C5D2 FBL4_ARATH 1.00E-13 IPR001810; IPR006553; F-box/LRR-repeat protein 4 (AtFBL4) FBL4 At4g15475 dl3775w FCAALL.58 Arabidopsis thaliana (Mouse-ear cress) TR34476_c0_g1_i2 Q9CZV8 FXL20_MOUSE 7.00E-14 GO:0005737 Q99NE5 cytoplasm IPR001810; IPR006553; F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like) Fbxl20 Fbl2 Mus musculus (Mouse) TR34476_c0_g1_i4 Q9QZH7 FXL20_RAT 2.00E-14 GO:0005737 cytoplasm IPR001810; IPR006553; F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like) Fbxl20 Fbl2 Rattus norvegicus (Rat) TR34478_c0_g1_i1 P79398 IF4G2_RABIT 2.00E-08 GO:0016281; GO:0006446; GO:0003743 eukaryotic translation initiation factor 4F complex; regulation of translational initiation; translation initiation factor activity IPR016024; IPR003891; IPR016021; IPR003890; IPR003307; Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Novel APOBEC-1 target 1) (Translation repressor NAT1) (p97) EIF4G2 NAT1 Oryctolagus cuniculus (Rabbit) TR34478_c1_g1_i1 Q13263 TIF1B_HUMAN 7.00E-06 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR34478_c2_g1_i1 Q04637 IF4G1_HUMAN 2.00E-49 GO:0008219; GO:0019221; GO:0005829; GO:0016281; GO:0008286; GO:0019048; GO:0000184; GO:0000289; GO:0006446; GO:0003743 O00571; O75822; P60842; P06730; Q14103-4; P11940 "cell death; cytokine-mediated signaling pathway; cytosol; eukaryotic translation initiation factor 4F complex; insulin receptor signaling pathway; modulation by virus of host morphology or physiology; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nuclear-transcribed mRNA poly(A) tail shortening; regulation of translational initiation; translation initiation factor activity" IPR016024; IPR003891; IPR016021; IPR003890; IPR003307; Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) EIF4G1 EIF4F EIF4G EIF4GI Homo sapiens (Human) TR34478_c2_g1_i2 Q04637 IF4G1_HUMAN 1.00E-31 GO:0008219; GO:0019221; GO:0005829; GO:0016281; GO:0008286; GO:0019048; GO:0000184; GO:0000289; GO:0006446; GO:0003743 O00571; O75822; P60842; P06730; Q14103-4; P11940 "cell death; cytokine-mediated signaling pathway; cytosol; eukaryotic translation initiation factor 4F complex; insulin receptor signaling pathway; modulation by virus of host morphology or physiology; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nuclear-transcribed mRNA poly(A) tail shortening; regulation of translational initiation; translation initiation factor activity" IPR016024; IPR003891; IPR016021; IPR003890; IPR003307; Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) EIF4G1 EIF4F EIF4G EIF4GI Homo sapiens (Human) TR34479_c1_g2_i1 Q923G2 RPAB3_MOUSE 4.00E-73 GO:0003677; GO:0005736; GO:0005665; GO:0005666; GO:0003899; GO:0006366 "DNA binding; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase activity; transcription from RNA polymerase II promoter" IPR012340; IPR005570; "DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (DNA-directed RNA polymerase II subunit H) (RPB17) (RPB8 homolog)" Polr2h Mus musculus (Mouse) TR34482_c1_g1_i1 Q24523 BUN2_DROME 6.00E-07 GO:0001751; GO:0005737; GO:0008101; GO:0008340; GO:0046843; GO:0007476; GO:0016319; GO:0045746; GO:0043066; GO:0009996; GO:0005634; GO:0007297; GO:0007422; GO:0030307; GO:0002052; GO:0042803; GO:0035071; GO:0035282; GO:0003700; GO:0042246; GO:0006351 "compound eye photoreceptor cell differentiation; cytoplasm; decapentaplegic signaling pathway; determination of adult lifespan; dorsal appendage formation; imaginal disc-derived wing morphogenesis; mushroom body development; negative regulation of Notch signaling pathway; negative regulation of apoptotic process; negative regulation of cell fate specification; nucleus; ovarian follicle cell migration; peripheral nervous system development; positive regulation of cell growth; positive regulation of neuroblast proliferation; protein homodimerization activity; salivary gland cell autophagic cell death; segmentation; sequence-specific DNA binding transcription factor activity; tissue regeneration; transcription, DNA-dependent" IPR000580; "Protein bunched, class 2/F/G isoform (Protein shortsighted)" bun shs CG42281 Drosophila melanogaster (Fruit fly) TR34482_c2_g3_i1 P62501 T22D1_RAT 5.00E-23 GO:0005737; GO:0005634; GO:0003700; GO:0006351 "cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000580; TSC22 domain family protein 1 (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) Tsc22d1 Tgfb1i4 Tsc22 Rattus norvegicus (Rat) TR34484_c1_g1_i1 Q9UJK0 TSR3_HUMAN 1.00E-73 GO:0006364 rRNA processing IPR007177; IPR022968; IPR007209; Ribosome biogenesis protein TSR3 homolog TSR3 C16orf42 UND313L Homo sapiens (Human) TR34484_c1_g1_i2 Q5HZH2 TSR3_MOUSE 2.00E-77 GO:0006364 rRNA processing IPR007177; IPR022968; IPR007209; Ribosome biogenesis protein TSR3 homolog Tsr3 Mus musculus (Mouse) TR34484_c1_g1_i3 Q5HZH2 TSR3_MOUSE 2.00E-77 GO:0006364 rRNA processing IPR007177; IPR022968; IPR007209; Ribosome biogenesis protein TSR3 homolog Tsr3 Mus musculus (Mouse) TR34484_c1_g1_i4 Q9UJK0 TSR3_HUMAN 1.00E-73 GO:0006364 rRNA processing IPR007177; IPR022968; IPR007209; Ribosome biogenesis protein TSR3 homolog TSR3 C16orf42 UND313L Homo sapiens (Human) TR34487_c0_g1_i1 Q9NWM0 SMOX_HUMAN 3.00E-77 GO:0052895; GO:0005737; GO:0005829; GO:0052894; GO:0005634; GO:0006596; GO:0006598; GO:0046592; GO:0044281; GO:0046208; GO:0052901; GO:0006805 N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity; cytoplasm; cytosol; norspermine:oxygen oxidoreductase activity; nucleus; polyamine biosynthetic process; polyamine catabolic process; polyamine oxidase activity; small molecule metabolic process; spermine catabolic process; spermine:oxygen oxidoreductase (spermidine-forming) activity; xenobiotic metabolic process IPR002937; Amine and polyamine degradation; spermine degradation. Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1) SMOX C20orf16 SMO UNQ3039/PRO9854 Homo sapiens (Human) TR34489_c0_g1_i2 Q9H9Q4 NHEJ1_HUMAN 4.00E-06 GO:0030183; GO:0003677; GO:0006310; GO:0030217; GO:0007417; GO:0006303; GO:0070419; GO:0005634; GO:0051351; GO:0010212 P49917; Q13426 B cell differentiation; DNA binding; DNA recombination; T cell differentiation; central nervous system development; double-strand break repair via nonhomologous end joining; nonhomologous end joining complex; nucleus; positive regulation of ligase activity; response to ionizing radiation IPR015381; IPR009089; Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor) NHEJ1 XLF Homo sapiens (Human) TR34489_c0_g2_i1 Q6NV18 NHEJ1_DANRE 1.00E-17 GO:0003677; GO:0006310; GO:0006302; GO:0070419; GO:0005634 DNA binding; DNA recombination; double-strand break repair; nonhomologous end joining complex; nucleus IPR015381; IPR009089; Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor) nhej1 xlf zgc:85657 Danio rerio (Zebrafish) (Brachydanio rerio) TR34489_c0_g2_i2 Q3KNJ2 NHEJ1_MOUSE 4.00E-14 GO:0030183; GO:0003677; GO:0006310; GO:0030217; GO:0006303; GO:0070419; GO:0005634; GO:0010212 B cell differentiation; DNA binding; DNA recombination; T cell differentiation; double-strand break repair via nonhomologous end joining; nonhomologous end joining complex; nucleus; response to ionizing radiation IPR015381; IPR009089; Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor) Nhej1 Xlf Mus musculus (Mouse) TR34490_c2_g2_i2 Q9BRR3 TM246_HUMAN 1.00E-53 GO:0016021 integral to membrane Transmembrane protein 246 TMEM246 C9orf125 Homo sapiens (Human) TR34490_c2_g2_i5 Q9BRR3 TM246_HUMAN 6.00E-51 GO:0016021 integral to membrane Transmembrane protein 246 TMEM246 C9orf125 Homo sapiens (Human) TR34491_c1_g1_i1 O15442 MPPD1_HUMAN 1.00E-81 GO:0016787 hydrolase activity IPR024201; IPR004843; Metallophosphoesterase domain-containing protein 1 (EC 3.1.-.-) (Adult brain protein 239) (239AB) MPPED1 C22orf1 FAM1A Homo sapiens (Human) TR34492_c1_g1_i3 Q9BX70 BTBD2_HUMAN 8.00E-41 GO:0000932 Q7L5N1; P04637 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) TR34492_c1_g1_i5 D3Z8N4 KLH20_RAT 5.00E-16 GO:0031463; GO:0005794; GO:0016605; GO:0009986; GO:0005737; GO:0019964; GO:0043066; GO:0048471; GO:0043161; GO:0004842 Cul3-RING ubiquitin ligase complex; Golgi apparatus; PML body; cell surface; cytoplasm; interferon-gamma binding; negative regulation of apoptotic process; perinuclear region of cytoplasm; proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 20 Klhl20 Rattus norvegicus (Rat) TR34492_c1_g1_i9 Q9BX70 BTBD2_HUMAN 5.00E-33 GO:0000932 Q7L5N1; P04637 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) TR34495_c0_g1_i1 Q7SZC5 NDC1_DANRE 2.00E-66 GO:0051028; GO:0031965; GO:0005643; GO:0015031 mRNA transport; nuclear membrane; nuclear pore; protein transport IPR019049; Nucleoporin NDC1 (Transmembrane protein 48) ndc1 tmem48 zgc:55636 Danio rerio (Zebrafish) (Brachydanio rerio) TR34496_c0_g2_i1 Q9CB01 RABF1_ARATH 3.00E-39 GO:0005525; GO:0003924; GO:0005769; GO:0031901; GO:0045022; GO:0006897; GO:0010009; GO:0005886; GO:0015031; GO:0007264 GTP binding; GTPase activity; early endosome; early endosome membrane; early endosome to late endosome transport; endocytosis; external side of endosome membrane; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein RABF1 (AtRABF1) (Ras-related protein Ara-6) (Ras-related protein Rab5C) (AtRab5C) RABF1 ARA-6 RAB5C At3g54840 F28P10.180 Arabidopsis thaliana (Mouse-ear cress) TR34496_c0_g2_i2 P53879 RHO5_YEAST 5.00E-06 GO:0005525; GO:0003924; GO:0007266; GO:0012505; GO:0000329; GO:0005886 GTP binding; GTPase activity; Rho protein signal transduction; endomembrane system; fungal-type vacuole membrane; plasma membrane IPR027417; IPR005225; IPR001806; IPR003578; GTP-binding protein RHO5 RHO5 YNL180C N1644 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR34498_c2_g1_i1 P08548 LIN1_NYCCO 1.00E-07 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR34500_c0_g1_i2 Q6ZR37 PKHG7_HUMAN 3.00E-28 GO:0005089; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; phospholipid binding; regulation of Rho protein signal transduction IPR000219; IPR011993; IPR001849; Pleckstrin homology domain-containing family G member 7 (PH domain-containing family G member 7) PLEKHG7 Homo sapiens (Human) TR34502_c0_g1_i1 Q8AWF5 NDC80_XENLA 3.00E-22 GO:0031262; GO:0051301; GO:0007059; GO:0000777; GO:0007067; GO:0007052; GO:0005634 Q8AWF4 Ndc80 complex; cell division; chromosome segregation; condensed chromosome kinetochore; mitosis; mitotic spindle organization; nucleus IPR005550; Kinetochore protein NDC80 homolog (Kinetochore protein Hec1) (Kinetochore-associated protein 2) (xNdc80) ndc80 kntc2 Xenopus laevis (African clawed frog) TR34502_c0_g1_i2 Q8AWF5 NDC80_XENLA 2.00E-22 GO:0031262; GO:0051301; GO:0007059; GO:0000777; GO:0007067; GO:0007052; GO:0005634 Q8AWF4 Ndc80 complex; cell division; chromosome segregation; condensed chromosome kinetochore; mitosis; mitotic spindle organization; nucleus IPR005550; Kinetochore protein NDC80 homolog (Kinetochore protein Hec1) (Kinetochore-associated protein 2) (xNdc80) ndc80 kntc2 Xenopus laevis (African clawed frog) TR34504_c1_g1_i1 Q8UWA5 CAH2_TRIHK 3.00E-81 GO:0004089; GO:0005737; GO:0006730; GO:0005886; GO:0008270 carbonate dehydratase activity; cytoplasm; one-carbon metabolic process; plasma membrane; zinc ion binding IPR001148; IPR023561; IPR018338; Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II) ca2 Tribolodon hakonensis (Big-scaled redfin) (Leuciscus hakonensis) TR34504_c1_g1_i4 Q8UWA5 CAH2_TRIHK 2.00E-81 GO:0004089; GO:0005737; GO:0006730; GO:0005886; GO:0008270 carbonate dehydratase activity; cytoplasm; one-carbon metabolic process; plasma membrane; zinc ion binding IPR001148; IPR023561; IPR018338; Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II) ca2 Tribolodon hakonensis (Big-scaled redfin) (Leuciscus hakonensis) TR34504_c1_g1_i5 O52538 CAH_ERWCA 4.00E-14 GO:0004089; GO:0006730; GO:0042597; GO:0008270 carbonate dehydratase activity; one-carbon metabolic process; periplasmic space; zinc ion binding IPR001148; IPR023561; IPR018338; Carbonic anhydrase (EC 4.2.1.1) (Carbonate dehydratase) cah Erwinia carotovora TR34506_c0_g1_i1 Q70JS2 KELC_ANOST 4.00E-50 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR006652; Ring canal kelch homolog (Kelch-like protein 1) [Cleaved into: Kelch short protein] kel Anopheles stephensi (Indo-Pakistan malaria mosquito) TR34508_c0_g1_i1 Q13423 NNTM_HUMAN 0 GO:0051287; GO:0008750; GO:0003957; GO:0050661; GO:0016021; GO:0005746; GO:0072593; GO:0044281; GO:0006099 NAD binding; NAD(P)+ transhydrogenase (AB-specific) activity; NAD(P)+ transhydrogenase (B-specific) activity; NADP binding; integral to membrane; mitochondrial respiratory chain; reactive oxygen species metabolic process; small molecule metabolic process; tricarboxylic acid cycle IPR008142; IPR008143; IPR007886; IPR007698; IPR012136; IPR026255; IPR024605; "NAD(P) transhydrogenase, mitochondrial (EC 1.6.1.2) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase)" NNT Homo sapiens (Human) TR34508_c0_g1_i2 Q13423 NNTM_HUMAN 0 GO:0051287; GO:0008750; GO:0003957; GO:0050661; GO:0016021; GO:0005746; GO:0072593; GO:0044281; GO:0006099 NAD binding; NAD(P)+ transhydrogenase (AB-specific) activity; NAD(P)+ transhydrogenase (B-specific) activity; NADP binding; integral to membrane; mitochondrial respiratory chain; reactive oxygen species metabolic process; small molecule metabolic process; tricarboxylic acid cycle IPR008142; IPR008143; IPR007886; IPR007698; IPR012136; IPR026255; IPR024605; "NAD(P) transhydrogenase, mitochondrial (EC 1.6.1.2) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase)" NNT Homo sapiens (Human) TR34508_c0_g1_i3 P43842 PNTA_HAEIN 1.00E-143 GO:0051287; GO:0008750; GO:0005887; GO:0046983; GO:0015992 NAD binding; NAD(P)+ transhydrogenase (AB-specific) activity; integral to plasma membrane; protein dimerization activity; proton transport IPR008142; IPR008143; IPR007886; IPR007698; IPR026255; IPR024605; NAD(P) transhydrogenase subunit alpha (EC 1.6.1.2) (Nicotinamide nucleotide transhydrogenase subunit alpha) (Pyridine nucleotide transhydrogenase subunit alpha) pntA HI_1362 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) TR34510_c1_g1_i2 Q5XGD9 ARI3A_XENTR 2.00E-81 GO:0003677; GO:0005737; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cytoplasm; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001606; IPR023334; AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A) (Bright homolog) (Dead ringer-like protein 1) arid3a dril1 TNeu118e10.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34510_c1_g1_i3 A6NKF2 ARI3C_HUMAN 1.00E-74 GO:0003677; GO:0003682; GO:0005737; GO:0045121; GO:0005634; GO:0045944; GO:0006351 "DNA binding; chromatin binding; cytoplasm; membrane raft; nucleus; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR001606; IPR023334; AT-rich interactive domain-containing protein 3C (ARID domain-containing protein 3C) ARID3C Homo sapiens (Human) TR34512_c0_g1_i1 A0JN51 ELF1_BOVIN 3.00E-14 GO:0005737; GO:0050860; GO:0005634; GO:0045944; GO:0001817; GO:0043565; GO:0003700; GO:0006351 "cytoplasm; negative regulation of T cell receptor signaling pathway; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of cytokine production; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR022084; IPR011991; ETS-related transcription factor Elf-1 (E74-like factor 1) ELF1 Bos taurus (Bovine) TR34512_c0_g1_i2 A0JN51 ELF1_BOVIN 3.00E-14 GO:0005737; GO:0050860; GO:0005634; GO:0045944; GO:0001817; GO:0043565; GO:0003700; GO:0006351 "cytoplasm; negative regulation of T cell receptor signaling pathway; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of cytokine production; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR022084; IPR011991; ETS-related transcription factor Elf-1 (E74-like factor 1) ELF1 Bos taurus (Bovine) TR34512_c0_g1_i3 P41163 ETV2_MOUSE 7.00E-10 GO:0060803; GO:0007219; GO:0016055; GO:0001824; GO:0048514; GO:0030218; GO:0005634; GO:0001890; GO:0045603; GO:2000382; GO:0045944; GO:0043565; GO:0003700 BMP signaling pathway involved in mesodermal cell fate specification; Notch signaling pathway; Wnt receptor signaling pathway; blastocyst development; blood vessel morphogenesis; erythrocyte differentiation; nucleus; placenta development; positive regulation of endothelial cell differentiation; positive regulation of mesoderm development; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR000418; IPR011991; ETS translocation variant 2 (Ets-related protein 71) Etv2 Er71 Etsrp71 Mus musculus (Mouse) TR34514_c0_g1_i1 Q8BGC0 HTSF1_MOUSE 4.00E-75 GO:0003723; GO:0000166; GO:0005634; GO:0006355; GO:0006351 "RNA binding; nucleotide binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR012677; IPR000504; HIV Tat-specific factor 1 homolog Htatsf1 Mus musculus (Mouse) TR34515_c1_g1_i1 Q91V57 CHIN_MOUSE 9.00E-35 GO:0005096; GO:0048013; GO:0005622; GO:0035556; GO:0046872; GO:0008045; GO:0043547; GO:0032314; GO:0050770 Q03137 GTPase activator activity; ephrin receptor signaling pathway; intracellular; intracellular signal transduction; metal ion binding; motor neuron axon guidance; positive regulation of GTPase activity; regulation of Rac GTPase activity; regulation of axonogenesis IPR020454; IPR017356; IPR002219; IPR008936; IPR000198; IPR000980; N-chimaerin (A-chimaerin) (Alpha-chimerin) (N-chimerin) (NC) (Rho GTPase-activating protein 2) Chn1 Arhgap2 Mus musculus (Mouse) TR34515_c2_g2_i1 P30337 CHIN_RAT 9.00E-32 GO:0005096; GO:0048013; GO:0005622; GO:0035556; GO:0046872; GO:0008045; GO:0001565; GO:0050770 GTPase activator activity; ephrin receptor signaling pathway; intracellular; intracellular signal transduction; metal ion binding; motor neuron axon guidance; phorbol ester receptor activity; regulation of axonogenesis IPR020454; IPR002219; IPR008936; IPR000198; N-chimaerin (A-chimaerin) (Alpha-chimerin) (N-chimerin) (NC) (Rho GTPase-activating protein 2) Chn1 Arhgap2 Chn Rattus norvegicus (Rat) TR34515_c2_g3_i1 O14014 RGA3_SCHPO 5.00E-08 GO:0005100; GO:0000935; GO:0051285; GO:0032153; GO:0005829; GO:0035556; GO:0008270 Rho GTPase activator activity; barrier septum; cell cortex of cell tip; cell division site; cytosol; intracellular signal transduction; zinc ion binding IPR002219; IPR008936; IPR000198; IPR001781; Probable Rho-type GTPase-activating protein 3 rga3 SPAC29A4.11 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR34515_c2_g4_i1 Q17QN0 CHIN_BOVIN 1.00E-56 GO:0005096; GO:0048013; GO:0005622; GO:0035556; GO:0046872; GO:0008045; GO:0043547; GO:0050770 GTPase activator activity; ephrin receptor signaling pathway; intracellular; intracellular signal transduction; metal ion binding; motor neuron axon guidance; positive regulation of GTPase activity; regulation of axonogenesis IPR020454; IPR002219; IPR008936; IPR000198; N-chimaerin (A-chimaerin) (Alpha-chimerin) (N-chimerin) (NC) (Rho GTPase-activating protein 2) CHN1 ARHGAP2 CHN Bos taurus (Bovine) TR34516_c2_g1_i1 Q4R535 CELF4_MACFA 1.00E-54 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0000166; GO:0005634; GO:0048026 "RNA binding; RNA splicing; cytoplasm; mRNA processing; nucleotide binding; nucleus; positive regulation of mRNA splicing, via spliceosome" IPR012677; IPR000504; CUGBP Elav-like family member 4 (CELF-4) (Bruno-like protein 4) (CUG-BP- and ETR-3-like factor 4) (RNA-binding protein BRUNOL-4) CELF4 BRUNOL4 QccE-21315 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR34516_c2_g2_i1 Q8N6W0 CELF5_HUMAN 7.00E-56 GO:0003723; GO:0005737; GO:0006397; GO:0000166; GO:0005634 RNA binding; cytoplasm; mRNA processing; nucleotide binding; nucleus IPR012677; IPR000504; CUGBP Elav-like family member 5 (CELF-5) (Bruno-like protein 5) (CUG-BP- and ETR-3-like factor 5) (RNA-binding protein BRUNOL-5) CELF5 BRUNOL5 Homo sapiens (Human) TR34516_c5_g1_i1 P0C6B8 SVEP1_RAT 2.00E-15 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) TR34516_c6_g1_i1 Q7TN33 CELF6_MOUSE 4.00E-50 GO:0003723; GO:0005737; GO:0006397; GO:0000166; GO:0005634; GO:0000381 "RNA binding; cytoplasm; mRNA processing; nucleotide binding; nucleus; regulation of alternative mRNA splicing, via spliceosome" IPR012677; IPR000504; CUGBP Elav-like family member 6 (CELF-6) (Bruno-like protein 6) (CUG-BP- and ETR-3-like factor 6) (RNA-binding protein BRUNOL-6) Celf6 Brunol6 Mus musculus (Mouse) TR34517_c0_g2_i1 Q9BHM6 OCDH_PECMA 8.00E-91 GO:0047830; GO:0051287; GO:0005737; GO:0046168; GO:0016616 "D-octopine dehydrogenase activity; NAD binding; cytoplasm; glycerol-3-phosphate catabolic process; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" IPR008927; IPR013328; IPR011128; IPR016040; IPR003421; Octopine dehydrogenase (OcDH) (EC 1.5.1.11) odh1 Pecten maximus (King scallop) (Pilgrim's clam) TR34518_c3_g3_i1 Q969G6 RIFK_HUMAN 2.00E-63 GO:0005524; GO:0009398; GO:0005829; GO:0046872; GO:0005739; GO:0009231; GO:0008531 ATP binding; FMN biosynthetic process; cytosol; metal ion binding; mitochondrion; riboflavin biosynthetic process; riboflavin kinase activity IPR023468; IPR015865; IPR023465; Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1. Riboflavin kinase (EC 2.7.1.26) (ATP:riboflavin 5'-phosphotransferase) (Flavokinase) RFK Homo sapiens (Human) TR34519_c3_g1_i1 Q9UPS8 ANR26_HUMAN 6.00E-16 GO:0005813 centrosome IPR002110; IPR020683; IPR021885; Ankyrin repeat domain-containing protein 26 ANKRD26 KIAA1074 Homo sapiens (Human) TR3452_c0_g1_i1 Q63170 DYH7_RAT 7.00E-13 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0005509; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; calcium ion binding; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR026983; IPR026979; IPR024743; IPR024317; IPR004273; IPR013602; IPR018247; IPR002048; IPR027417; "Dynein heavy chain 7, axonemal (Axonemal beta dynein heavy chain 7) (Axonemal dynein heavy chain b) (Ciliary dynein heavy chain 7) (Dynein-like protein 7)" Dnah7 Axob Dlp7 Rattus norvegicus (Rat) TR34520_c1_g1_i1 Q28620 NPT2A_RABIT 1.00E-35 GO:0016021; GO:0055062; GO:0046686; GO:0010288; GO:0046689; GO:0006814; GO:0015321; GO:0015293 integral to membrane; phosphate ion homeostasis; response to cadmium ion; response to lead ion; response to mercury ion; sodium ion transport; sodium-dependent phosphate transmembrane transporter activity; symporter activity IPR003841; Sodium-dependent phosphate transport protein 2A (Sodium-phosphate transport protein 2A) (Na(+)-dependent phosphate cotransporter 2A) (NaPi-6) (Sodium/phosphate cotransporter 2A) (Na(+)/Pi cotransporter 2A) (NaPi-2a) (Solute carrier family 34 member 1) SLC34A1 SLC17A2 Oryctolagus cuniculus (Rabbit) TR34520_c1_g1_i2 O97704 NPT2A_SHEEP 5.00E-115 GO:0016021; GO:0055062; GO:0006814; GO:0015321; GO:0015293 integral to membrane; phosphate ion homeostasis; sodium ion transport; sodium-dependent phosphate transmembrane transporter activity; symporter activity IPR003841; Sodium-dependent phosphate transport protein 2A (Sodium-phosphate transport protein 2A) (Na(+)-dependent phosphate cotransporter 2A) (Sodium/phosphate cotransporter 2A) (Na(+)/Pi cotransporter 2A) (NaPi-2a) (Solute carrier family 34 member 1) SLC34A1 NPT2 SLC17A2 Ovis aries (Sheep) TR34521_c2_g1_i2 Q9NUV9 GIMA4_HUMAN 1.00E-35 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR34521_c2_g1_i3 Q9UG22 GIMA2_HUMAN 2.00E-26 GO:0005525; GO:0016021; GO:0005811 GTP binding; integral to membrane; lipid particle IPR006703; IPR027417; GTPase IMAP family member 2 (Immunity-associated protein 2) (hIMAP2) GIMAP2 IMAP2 Homo sapiens (Human) TR34521_c2_g1_i4 Q99JY3 GIMA4_MOUSE 2.00E-26 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Mus musculus (Mouse) TR34524_c0_g1_i2 Q66JZ4 CC023_MOUSE 1.00E-69 GO:0005739 mitochondrion IPR028031; IPR027989; IPR027986; "T-cell activation inhibitor, mitochondrial (Tolerance associated gene-1 protein) (TOAG-1)" TCAIM D9Ertd402e Toag1 Mus musculus (Mouse) TR34529_c0_g1_i1 A0JMY4 CN045_XENLA 2.00E-99 Basal body-orientation factor 1 (Coiled-coil domain-containing protein 176) ccdc176 bbof1 Xenopus laevis (African clawed frog) TR34529_c0_g1_i5 Q8ND07 CN045_HUMAN 7.00E-100 Basal body-orientation factor 1 (Coiled-coil domain-containing protein 176) CCDC176 BBOF1 C14orf45 Homo sapiens (Human) TR34531_c1_g2_i1 A4QNI8 ELAV4_XENTR 3.00E-73 GO:0003723; GO:0007275; GO:0000166; GO:0030529 RNA binding; multicellular organismal development; nucleotide binding; ribonucleoprotein complex IPR006548; IPR002343; IPR012677; IPR000504; ELAV-like protein 4 (Protein ElrD) elavl4 elrD Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34531_c1_g2_i2 Q28GD4 ELAV2_XENTR 3.00E-83 GO:0003723; GO:0005938; GO:0007275; GO:0000166; GO:0030529 RNA binding; cell cortex; multicellular organismal development; nucleotide binding; ribonucleoprotein complex IPR006548; IPR002343; IPR012677; IPR000504; ELAV-like protein 2 (Protein ElrB) elavl2 elrB TEgg126j06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34533_c0_g1_i1 P34981 TRFR_HUMAN 2.00E-08 GO:0005887; GO:0004997 integral to plasma membrane; thyrotropin-releasing hormone receptor activity IPR000276; IPR017452; IPR002120; Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor) TRHR Homo sapiens (Human) TR34534_c2_g1_i2 Q9UJU3 ZF112_HUMAN 4.00E-25 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 112 (Zfp-112) (Zinc finger protein 228) ZNF112 ZFP112 ZNF228 Homo sapiens (Human) TR34538_c2_g3_i3 B1AL88 F155A_HUMAN 2.00E-07 GO:0016021 integral to membrane Transmembrane protein FAM155A FAM155A Homo sapiens (Human) TR34538_c3_g1_i1 Q5ZHW4 RAB5B_CHICK 1.00E-118 GO:0019003; GO:0005525; GO:0031901; GO:0005886; GO:0015031; GO:0007264 GDP binding; GTP binding; early endosome membrane; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-5B RAB5B RCJMB04_32j11 Gallus gallus (Chicken) TR34541_c0_g1_i1 A6NHZ5 LR14B_HUMAN 1.00E-06 IPR026292; Leucine-rich repeat-containing protein 14B LRRC14B Homo sapiens (Human) TR34541_c0_g1_i2 A6NHZ5 LR14B_HUMAN 1.00E-06 IPR026292; Leucine-rich repeat-containing protein 14B LRRC14B Homo sapiens (Human) TR34543_c1_g1_i1 Q6UXZ4 UNC5D_HUMAN 3.00E-19 GO:0006915; GO:0007411; GO:0009986; GO:0016021; GO:0007165 apoptotic process; axon guidance; cell surface; integral to membrane; signal transduction IPR011029; IPR000488; IPR007110; IPR013783; IPR013098; IPR003598; IPR000884; IPR000906; Netrin receptor UNC5D (Protein unc-5 homolog 4) (Protein unc-5 homolog D) UNC5D KIAA1777 UNC5H4 UNQ6012/PRO34692 Homo sapiens (Human) TR34543_c1_g1_i2 P07996 TSP1_HUMAN 9.00E-19 GO:0000187; GO:0048266; GO:0005509; GO:0007155; GO:0007050; GO:0016477; GO:0034605; GO:0002544; GO:0070052; GO:0003197; GO:0043652; GO:0009897; GO:0031012; GO:0030198; GO:0070062; GO:0070051; GO:0005577; GO:0017134; GO:0001968; GO:0003417; GO:0008201; GO:0042802; GO:0006955; GO:0005178; GO:0043236; GO:0030169; GO:0016525; GO:0002581; GO:0043066; GO:0043537; GO:0010754; GO:0043154; GO:0002605; GO:0001937; GO:2001237; GO:0051918; GO:0040037; GO:0051895; GO:0032695; GO:0010751; GO:0010748; GO:0010757; GO:0003151; GO:0018149; GO:0001786; GO:0030168; GO:0031093; GO:0002576; GO:0045766; GO:0043536; GO:0010811; GO:2000353; GO:1900119; GO:1902043; GO:0010763; GO:0043032; GO:0010759; GO:0051897; GO:2000379; GO:0030511; GO:0032914; GO:0045727; GO:0042535; GO:0043394; GO:0051592; GO:0042493; GO:0034976; GO:0009749; GO:0001666; GO:0032026; GO:0032570; GO:0016529; GO:0002040; GO:0050431 P01137 activation of MAPK activity; behavioral response to pain; calcium ion binding; cell adhesion; cell cycle arrest; cell migration; cellular response to heat; chronic inflammatory response; collagen V binding; endocardial cushion development; engulfment of apoptotic cell; external side of plasma membrane; extracellular matrix; extracellular matrix organization; extracellular vesicular exosome; fibrinogen binding; fibrinogen complex; fibroblast growth factor binding; fibronectin binding; growth plate cartilage development; heparin binding; identical protein binding; immune response; integrin binding; laminin binding; low-density lipoprotein particle binding; negative regulation of angiogenesis; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; negative regulation of apoptotic process; negative regulation of blood vessel endothelial cell migration; negative regulation of cGMP-mediated signaling; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of dendritic cell antigen processing and presentation; negative regulation of endothelial cell proliferation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of fibrinolysis; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of focal adhesion assembly; negative regulation of interleukin-12 production; negative regulation of nitric oxide mediated signal transduction; negative regulation of plasma membrane long-chain fatty acid transport; negative regulation of plasminogen activation; outflow tract morphogenesis; peptide cross-linking; phosphatidylserine binding; platelet activation; platelet alpha granule lumen; platelet degranulation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell-substrate adhesion; positive regulation of endothelial cell apoptotic process; positive regulation of execution phase of apoptosis; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of fibroblast migration; positive regulation of macrophage activation; positive regulation of macrophage chemotaxis; positive regulation of protein kinase B signaling cascade; positive regulation of reactive oxygen species metabolic process; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of transforming growth factor beta1 production; positive regulation of translation; positive regulation of tumor necrosis factor biosynthetic process; proteoglycan binding; response to calcium ion; response to drug; response to endoplasmic reticulum stress; response to glucose stimulus; response to hypoxia; response to magnesium ion; response to progesterone stimulus; sarcoplasmic reticulum; sprouting angiogenesis; transforming growth factor beta binding IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR001791; IPR000884; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-1 THBS1 TSP TSP1 Homo sapiens (Human) TR34543_c1_g1_i4 Q96RW7 HMCN1_HUMAN 3.00E-34 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR34543_c2_g1_i1 Q99N02 SO3A1_RAT 6.00E-15 GO:0016021; GO:0005886; GO:0015732; GO:0005215 integral to membrane; plasma membrane; prostaglandin transport; transporter activity IPR002350; IPR016196; IPR004156; Solute carrier organic anion transporter family member 3A1 (Organic anion-transporting polypeptide D) (OATP-D) (Prostaglandin transporter subtype 2) (Sodium-independent organic anion transporter D) (Solute carrier family 21 member 11) Slco3a1 Oatp3a1 Oatpd Pgt2 Slc21a11 Rattus norvegicus (Rat) TR34543_c2_g1_i2 Q9EP96 SO1A4_MOUSE 4.00E-08 GO:0016021; GO:0016020; GO:0008514; GO:0005886 integral to membrane; membrane; organic anion transmembrane transporter activity; plasma membrane IPR002350; IPR020846; IPR016196; IPR004156; Solute carrier organic anion transporter family member 1A4 (Sodium-independent organic anion-transporting polypeptide 2) (Solute carrier family 21 member 5) Slco1a4 Oatp1a4 Oatp2 Slc21a5 Mus musculus (Mouse) TR34543_c3_g1_i1 P82596 PLC_HALLA 1.00E-17 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR34543_c3_g1_i3 P13611 CSPG2_HUMAN 5.00E-12 GO:0005796; GO:0005509; GO:0030246; GO:0005975; GO:0007155; GO:0008037; GO:0030206; GO:0030207; GO:0030208; GO:0030198; GO:0005615; GO:0008347; GO:0007507; GO:0005540; GO:0043202; GO:0007275; GO:0005578 P14780 Golgi lumen; calcium ion binding; carbohydrate binding; carbohydrate metabolic process; cell adhesion; cell recognition; chondroitin sulfate biosynthetic process; chondroitin sulfate catabolic process; dermatan sulfate biosynthetic process; extracellular matrix organization; extracellular space; glial cell migration; heart development; hyaluronic acid binding; lysosomal lumen; multicellular organismal development; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Homo sapiens (Human) TR34543_c3_g1_i4 Q149M0 CL12B_MOUSE 3.00E-12 GO:0030246; GO:0016021; GO:0005886 carbohydrate binding; integral to membrane; plasma membrane IPR001304; IPR016186; IPR016187; IPR013600; C-type lectin domain family 12 member B Clec12b Mus musculus (Mouse) TR34543_c3_g1_i6 Q13018 PLA2R_HUMAN 9.00E-09 GO:0030246; GO:0009986; GO:0001816; GO:0005576; GO:0016021; GO:0005887; GO:1900139; GO:1900138; GO:0090403; GO:0005886; GO:0043517; GO:0090238; GO:0072593; GO:0004872; GO:0006898; GO:0090399 "carbohydrate binding; cell surface; cytokine production; extracellular region; integral to membrane; integral to plasma membrane; negative regulation of arachidonic acid secretion; negative regulation of phospholipase A2 activity; oxidative stress-induced premature senescence; plasma membrane; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of arachidonic acid secretion; reactive oxygen species metabolic process; receptor activity; receptor-mediated endocytosis; replicative senescence" IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR000772; Secretory phospholipase A2 receptor (PLA2-R) (PLA2R) (180 kDa secretory phospholipase A2 receptor) (C-type lectin domain family 13 member C) (M-type receptor) [Cleaved into: Soluble secretory phospholipase A2 receptor (Soluble PLA2-R) (Soluble PLA2R)] PLA2R1 CLEC13C Homo sapiens (Human) TR34543_c3_g1_i7 Q9UJ71 CLC4K_HUMAN 7.00E-18 GO:0002479; GO:0030669; GO:0051607; GO:0031901; GO:0016021; GO:0005537; GO:0005886 "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; clathrin-coated endocytic vesicle membrane; defense response to virus; early endosome membrane; integral to membrane; mannose binding; plasma membrane" IPR001304; IPR016186; IPR018378; IPR016187; C-type lectin domain family 4 member K (Langerin) (CD antigen CD207) CD207 CLEC4K Homo sapiens (Human) TR34543_c3_g1_i8 P82596 PLC_HALLA 4.00E-18 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR34544_c0_g1_i2 Q5R9R1 EDRF1_PONAB 0 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" Erythroid differentiation-related factor 1 EDRF1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34545_c4_g2_i2 Q6P828 LITAF_XENTR 2.00E-18 GO:0005737; GO:0006355; GO:0006351 "cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) litaf TEgg087j16.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34545_c4_g2_i3 Q6GMG8 LITAF_DANRE 4.00E-22 GO:0005737; GO:0006355; GO:0006351 "cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) litaf zgc:91882 Danio rerio (Zebrafish) (Brachydanio rerio) TR34547_c0_g1_i1 Q54EC2 DDX55_DICDI 8.00E-136 GO:0005524; GO:0008026; GO:0003723; GO:0005730; GO:0006364 ATP binding; ATP-dependent helicase activity; RNA binding; nucleolus; rRNA processing IPR011545; IPR025313; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase ddx55 (EC 3.6.4.13) (DEAD box protein 55) ddx55 DDB_G0291588 Dictyostelium discoideum (Slime mold) TR34547_c0_g1_i2 Q6ZPL9 DDX55_MOUSE 0 GO:0005524; GO:0008026; GO:0003723 ATP binding; ATP-dependent helicase activity; RNA binding IPR011545; IPR025313; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DDX55 (EC 3.6.4.13) (DEAD box protein 55) Ddx55 Kiaa1595 Mus musculus (Mouse) TR34548_c4_g2_i7 Q7Z0T3 TEMPT_APLCA 4.00E-21 GO:0005576 extracellular region Temptin Aplysia californica (California sea hare) TR34549_c1_g2_i1 Q6XHB2 ROCO4_DICDI 1.00E-07 GO:0005524; GO:0005525; GO:0005829; GO:0004672; GO:0004674; GO:0031153; GO:0007264; GO:0031150 ATP binding; GTP binding; cytosol; protein kinase activity; protein serine/threonine kinase activity; slug development involved in sorocarp development; small GTPase mediated signal transduction; sorocarp stalk development IPR011009; IPR001611; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR001245; IPR015943; IPR001680; IPR017986; Probable serine/threonine-protein kinase roco4 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 4) roco4 DDB_G0288251 Dictyostelium discoideum (Slime mold) TR34550_c5_g3_i1 P02746 C1QB_HUMAN 9.00E-07 GO:0005581; GO:0006958; GO:0005602; GO:0045087; GO:0048839 P02745 "collagen; complement activation, classical pathway; complement component C1 complex; innate immune response; inner ear development" IPR001073; IPR008160; IPR008983; Complement C1q subcomponent subunit B C1QB Homo sapiens (Human) TR34551_c0_g2_i1 P97300 NPTN_MOUSE 1.00E-07 GO:0050839; GO:0007204; GO:0007156; GO:0016021; GO:0060291; GO:0045743; GO:0048170; GO:0010976; GO:0001934; GO:0042734; GO:0005105 cell adhesion molecule binding; elevation of cytosolic calcium ion concentration; homophilic cell adhesion; integral to membrane; long-term synaptic potentiation; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of long-term neuronal synaptic plasticity; positive regulation of neuron projection development; positive regulation of protein phosphorylation; presynaptic membrane; type 1 fibroblast growth factor receptor binding IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR027112; Neuroplastin (Stromal cell-derived receptor 1) (SDR-1) Nptn Sdfr1 Sdr1 Mus musculus (Mouse) TR34551_c0_g2_i2 Q8NDA2 HMCN2_HUMAN 6.00E-06 GO:0005509; GO:0005578; GO:0050896 calcium ion binding; proteinaceous extracellular matrix; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 HMCN2 Homo sapiens (Human) TR34552_c6_g2_i2 Q9UL36 ZN236_HUMAN 6.00E-09 GO:0003677; GO:0071333; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; cellular response to glucose stimulus; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 236 ZNF236 Homo sapiens (Human) TR34554_c0_g1_i1 Q09226 ALG6_CAEEL 3.00E-61 GO:0005789; GO:0016021; GO:0006486; GO:0016758 "endoplasmic reticulum membrane; integral to membrane; protein glycosylation; transferase activity, transferring hexosyl groups" IPR004856; Protein modification; protein glycosylation. "Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6 homolog) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase)" C08B11.8 Caenorhabditis elegans TR34554_c0_g1_i3 Q3TAE8 ALG6_MOUSE 3.00E-78 GO:0005789; GO:0016021; GO:0006486; GO:0016758 "endoplasmic reticulum membrane; integral to membrane; protein glycosylation; transferase activity, transferring hexosyl groups" IPR004856; Protein modification; protein glycosylation. "Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6 homolog) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase)" Alg6 Mus musculus (Mouse) TR34554_c0_g1_i4 Q3TAE8 ALG6_MOUSE 6.00E-144 GO:0005789; GO:0016021; GO:0006486; GO:0016758 "endoplasmic reticulum membrane; integral to membrane; protein glycosylation; transferase activity, transferring hexosyl groups" IPR004856; Protein modification; protein glycosylation. "Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6 homolog) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase)" Alg6 Mus musculus (Mouse) TR34556_c0_g2_i1 Q9UBX8 B4GT6_HUMAN 3.00E-65 GO:0032580; GO:0000139; GO:0008489; GO:0008378; GO:0016021; GO:0018146; GO:0046872; GO:0043687; GO:0018279 "Golgi cisterna membrane; Golgi membrane; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity; galactosyltransferase activity; integral to membrane; keratan sulfate biosynthetic process; metal ion binding; post-translational protein modification; protein N-linked glycosylation via asparagine" IPR003859; IPR027791; IPR027995; Protein modification; protein glycosylation. "Beta-1,4-galactosyltransferase 6 (Beta-1,4-GalTase 6) (Beta4Gal-T6) (b4Gal-T6) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6) [Includes: Glucosylceramide beta-1,4-galactosyltransferase (EC 2.4.1.274) (Lactosylceramide synthase) (LacCer synthase) (UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase)]" B4GALT6 Homo sapiens (Human) TR34556_c0_g2_i6 Q09323 BAGT_LYMST 4.00E-50 GO:0000139; GO:0016021; GO:0006486; GO:0016757 "Golgi membrane; integral to membrane; protein glycosylation; transferase activity, transferring glycosyl groups" IPR003859; IPR027791; IPR027995; Protein modification; protein glycosylation. "Beta-N-acetyl-D-glucosaminide beta-1,4-N-acetylglucosaminyl-transferase (EC 2.4.1.-) (Beta-1,4-GlcNAcT) (UDP-GlcNAc:GlcNAc beta-R beta-1,4-N-acetylglucosaminyl-transferase)" GNT Lymnaea stagnalis (Great pond snail) TR34557_c0_g1_i1 P95957 Y104_SULSO 4.00E-47 GO:0009058; GO:0005737; GO:0030170; GO:0008483 biosynthetic process; cytoplasm; pyridoxal phosphate binding; transaminase activity IPR004839; IPR015424; IPR015421; IPR015422; Uncharacterized aminotransferase SSO0104 (EC 2.6.1.-) (AspB-1) SSO0104 C04018 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) TR34559_c3_g4_i1 Q2KI92 IMP2L_BOVIN 3.00E-18 GO:0016021; GO:0005743; GO:0005634; GO:0001541; GO:0030728; GO:0006508; GO:0008236; GO:0007283 integral to membrane; mitochondrial inner membrane; nucleus; ovarian follicle development; ovulation; proteolysis; serine-type peptidase activity; spermatogenesis IPR000223; IPR019758; IPR028360; IPR019759; IPR015927; Mitochondrial inner membrane protease subunit 2 (EC 3.4.21.-) (IMP2-like protein) IMMP2L Bos taurus (Bovine) TR34559_c3_g4_i4 Q9CQU8 IMP1L_MOUSE 1.00E-51 GO:0042720; GO:0005739; GO:0006627; GO:0006508; GO:0008236 mitochondrial inner membrane peptidase complex; mitochondrion; protein processing involved in protein targeting to mitochondrion; proteolysis; serine-type peptidase activity IPR026730; IPR000223; IPR028360; IPR019759; IPR015927; IPR019533; Mitochondrial inner membrane protease subunit 1 (EC 3.4.21.-) (IMP1-like protein) Immp1l Mus musculus (Mouse) TR34559_c3_g4_i7 Q9UST2 IMP2L_SCHPO 1.00E-14 GO:0016021; GO:0004222; GO:0042720; GO:0005739; GO:0006627; GO:0006508; GO:0008236 integral to membrane; metalloendopeptidase activity; mitochondrial inner membrane peptidase complex; mitochondrion; protein processing involved in protein targeting to mitochondrion; proteolysis; serine-type peptidase activity IPR026730; IPR000223; IPR028360; IPR019759; IPR015927; Mitochondrial inner membrane protease subunit 2 (EC 3.4.21.-) SPBC336.13c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR34559_c4_g1_i1 Q96DM1 PGBD4_HUMAN 2.00E-09 PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) TR34560_c1_g1_i1 P56719 OX2R_RAT 4.00E-61 GO:0022410; GO:0007631; GO:0016021; GO:0007218; GO:0016499; GO:0017046; GO:0007200; GO:0005886 circadian sleep/wake cycle process; feeding behavior; integral to membrane; neuropeptide signaling pathway; orexin receptor activity; peptide hormone binding; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane IPR000276; IPR017452; IPR000204; IPR004060; Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Rattus norvegicus (Rat) TR34560_c1_g2_i1 P56719 OX2R_RAT 2.00E-32 GO:0022410; GO:0007631; GO:0016021; GO:0007218; GO:0016499; GO:0017046; GO:0007200; GO:0005886 circadian sleep/wake cycle process; feeding behavior; integral to membrane; neuropeptide signaling pathway; orexin receptor activity; peptide hormone binding; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane IPR000276; IPR017452; IPR000204; IPR004060; Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Rattus norvegicus (Rat) TR34561_c2_g1_i1 Q6YHK3 CD109_HUMAN 4.00E-37 GO:0031225; GO:0005615; GO:0010951; GO:0005886; GO:0004867 anchored to membrane; extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) TR34562_c0_g1_i2 Q01460 DIAC_RAT 1.00E-101 GO:0006032; GO:0004568; GO:0005764; GO:0009313 chitin catabolic process; chitinase activity; lysosome; oligosaccharide catabolic process IPR011583; IPR001223; IPR001579; IPR013781; IPR017853; Di-N-acetylchitobiase (EC 3.2.1.-) Ctbs Ctb Rattus norvegicus (Rat) TR34562_c0_g1_i3 Q01460 DIAC_RAT 2.00E-100 GO:0006032; GO:0004568; GO:0005764; GO:0009313 chitin catabolic process; chitinase activity; lysosome; oligosaccharide catabolic process IPR011583; IPR001223; IPR001579; IPR013781; IPR017853; Di-N-acetylchitobiase (EC 3.2.1.-) Ctbs Ctb Rattus norvegicus (Rat) TR34563_c1_g1_i2 Q9H0E3 SP130_HUMAN 1.00E-40 GO:0030914; GO:0043966; GO:0000122; GO:0003713; GO:0006351 "STAGA complex; histone H3 acetylation; negative regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcription, DNA-dependent" IPR024137; Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) SAP130 Homo sapiens (Human) TR34564_c0_g1_i1 Q9QYG6 CP2DR_MESAU 4.00E-76 GO:0005789; GO:0020037; GO:0005506; GO:0016712 "endoplasmic reticulum membrane; heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen" IPR001128; IPR017972; IPR002401; IPR008069; Cytochrome P450 2D27 (EC 1.14.14.-) (CYPIID27) CYP2D27 Mesocricetus auratus (Golden hamster) TR34564_c0_g1_i2 Q64403 CP2DG_CAVPO 2.00E-61 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; IPR008069; Cytochrome P450 2D16 (EC 1.14.14.1) (CYPIID16) CYP2D16 Cavia porcellus (Guinea pig) TR34565_c0_g1_i1 Q13371 PHLP_HUMAN 3.00E-69 GO:0061084; GO:0006457; GO:0007165; GO:0007601 negative regulation of protein refolding; protein folding; signal transduction; visual perception IPR001200; IPR023196; IPR024253; IPR012336; Phosducin-like protein (PHLP) PDCL Homo sapiens (Human) TR34566_c0_g1_i1 Q8QZX5 LSM10_MOUSE 1.00E-16 GO:0015030; GO:0008380; GO:0005683; GO:0071208; GO:0006397; GO:0000084; GO:0017069 Cajal body; RNA splicing; U7 snRNP; histone pre-mRNA DCP binding; mRNA processing; mitotic S phase; snRNA binding IPR010920; IPR001163; IPR006649; U7 snRNA-associated Sm-like protein LSm10 Lsm10 Mus musculus (Mouse) TR34566_c0_g1_i2 Q54F84 Y1015_DICDI 4.00E-07 IPR010920; IPR001163; Putative uncharacterized protein DDB_G0291015 DDB_G0291015 Dictyostelium discoideum (Slime mold) TR34567_c0_g1_i1 P02513 HSP17_CAEEL 4.00E-11 GO:0008340; GO:0006950 determination of adult lifespan; response to stress IPR002068; IPR001436; IPR008978; Heat shock protein Hsp-16.48/Hsp-16.49 hsp-16.48 hsp16-48 hsp16-48a T27E4.3; hsp-16.49 hsp16-48b hsp16-49 T27E4.9 Caenorhabditis elegans TR34567_c0_g1_i2 Q90497 CRYAA_EUDEL 2.00E-21 GO:0046872; GO:0005212 metal ion binding; structural constituent of eye lens IPR002068; IPR001436; IPR012274; IPR003090; IPR008978; Alpha-crystallin A chain (Fragment) CRYAA Eudromia elegans (Elegant crested-tinamou) TR34567_c0_g1_i3 O93591 CRYAA_ASTFA 4.00E-23 GO:0046872; GO:0005212 metal ion binding; structural constituent of eye lens IPR002068; IPR001436; IPR012274; IPR003090; IPR008978; Alpha-crystallin A chain cryaa Astyanax fasciatus (Blind cave fish) (Astyanax mexicanus) TR34567_c0_g1_i4 P02488 CRYAA_MACMU 3.00E-21 GO:0007015; GO:0060561; GO:0005737; GO:0048596; GO:0070309; GO:0046872; GO:0007005; GO:0043066; GO:0043154; GO:0010629; GO:0032387; GO:0005634; GO:0030307; GO:0001934; GO:0051260; GO:0070141; GO:0042542; GO:0001666; GO:0005212; GO:0007021; GO:0007601 actin filament organization; apoptotic process involved in morphogenesis; cytoplasm; embryonic camera-type eye morphogenesis; lens fiber cell morphogenesis; metal ion binding; mitochondrion organization; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of gene expression; negative regulation of intracellular transport; nucleus; positive regulation of cell growth; positive regulation of protein phosphorylation; protein homooligomerization; response to UV-A; response to hydrogen peroxide; response to hypoxia; structural constituent of eye lens; tubulin complex assembly; visual perception IPR002068; IPR001436; IPR012274; IPR003090; IPR008978; Alpha-crystallin A chain CRYAA Macaca mulatta (Rhesus macaque) TR34568_c0_g1_i1 Q925N0 SFXN5_MOUSE 3.00E-115 GO:0008324; GO:0016021; GO:0055072; GO:0005743 cation transmembrane transporter activity; integral to membrane; iron ion homeostasis; mitochondrial inner membrane IPR004686; Sideroflexin-5 Sfxn5 Mus musculus (Mouse) TR34568_c0_g1_i3 Q925N0 SFXN5_MOUSE 2.00E-115 GO:0008324; GO:0016021; GO:0055072; GO:0005743 cation transmembrane transporter activity; integral to membrane; iron ion homeostasis; mitochondrial inner membrane IPR004686; Sideroflexin-5 Sfxn5 Mus musculus (Mouse) TR34569_c0_g1_i1 A0JMH2 CB069_DANRE 6.00E-51 GO:0005576 extracellular region IPR018881; UPF0565 protein C2orf69 homolog zgc:153521 Danio rerio (Zebrafish) (Brachydanio rerio) TR34570_c3_g3_i1 Q1JQ66 S35E3_DANRE 3.00E-96 GO:0016021 integral to membrane IPR004853; Solute carrier family 35 member E3 slc35e3 Danio rerio (Zebrafish) (Brachydanio rerio) TR34571_c0_g1_i1 P86952 TYRO_PINMA 3.00E-51 GO:0005576; GO:0046872; GO:0055114; GO:0016491 extracellular region; metal ion binding; oxidation-reduction process; oxidoreductase activity IPR002227; IPR008922; Tyrosinase-like protein (Tyrosinase-2) Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) TR34571_c0_g1_i2 H2A0L0 TYRO1_PINMG 3.00E-42 GO:0005576; GO:0046872; GO:0016491 extracellular region; metal ion binding; oxidoreductase activity IPR002227; IPR008922; Tyrosinase-like protein 1 (EC 1.14.18.-) (Tyrosinase 1) Pinctada margaritifera (Black-lipped pearl oyster) TR34571_c0_g1_i3 P33180 TYRO_RHIML 6.00E-09 GO:0042438; GO:0046872; GO:0004503 melanin biosynthetic process; metal ion binding; monophenol monooxygenase activity IPR002227; IPR008922; Tyrosinase (EC 1.14.18.1) (Monophenol monooxygenase) mepA melA Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) TR34571_c0_g1_i4 Q00024 PPO1_AGABI 3.00E-07 GO:0042438; GO:0046872; GO:0004503 melanin biosynthetic process; metal ion binding; monophenol monooxygenase activity IPR016216; IPR002227; IPR008922; Polyphenol oxidase 1 (PPO1) (Phenolase 1) (EC 1.14.18.1) (Cresolase 1) (Tyrosinase 1) PPO1 Agaricus bisporus (White button mushroom) TR34572_c3_g1_i1 Q6CEW9 MRD1_YARLI 4.00E-07 GO:0003723; GO:0000166; GO:0005634; GO:0006364; GO:0030529 RNA binding; nucleotide binding; nucleus; rRNA processing; ribonucleoprotein complex IPR012677; IPR000504; Multiple RNA-binding domain-containing protein 1 MRD1 YALI0B12276g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR34572_c3_g1_i2 Q91903 ELAV2_XENLA 3.00E-08 GO:0005938; GO:0008298; GO:0003730; GO:0000122; GO:0007399; GO:0000166; GO:0051260; GO:0030529; GO:0017131 cell cortex; intracellular mRNA localization; mRNA 3'-UTR binding; negative regulation of transcription from RNA polymerase II promoter; nervous system development; nucleotide binding; protein homooligomerization; ribonucleoprotein complex; uridine-rich cytoplasmic polyadenylylation element binding IPR006548; IPR002343; IPR012677; IPR000504; ELAV-like protein 2 (Elav like-1) (Xel-1) (Protein ElrB) (p45) elavl2 el-1 elavl2-a elrB Xenopus laevis (African clawed frog) TR34572_c3_g1_i3 Q28GD4 ELAV2_XENTR 3.00E-09 GO:0003723; GO:0005938; GO:0007275; GO:0000166; GO:0030529 RNA binding; cell cortex; multicellular organismal development; nucleotide binding; ribonucleoprotein complex IPR006548; IPR002343; IPR012677; IPR000504; ELAV-like protein 2 (Protein ElrB) elavl2 elrB TEgg126j06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34572_c3_g1_i5 Q5R1W5 SRSF2_PANTR 2.00E-44 GO:0003723; GO:0008380; GO:0006397; GO:0016607; GO:0000166 RNA binding; RNA splicing; mRNA processing; nuclear speck; nucleotide binding IPR012677; IPR000504; "Serine/arginine-rich splicing factor 2 (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)" SRSF2 SFRS2 Pan troglodytes (Chimpanzee) TR34573_c0_g1_i1 P06105 SC160_YEAST 4.00E-17 GO:0003723; GO:0030466; GO:0006348; GO:0007059; GO:0005789; GO:0008298; GO:0045141; GO:0031965; GO:0000750; GO:0005844 RNA binding; chromatin silencing at silent mating-type cassette; chromatin silencing at telomere; chromosome segregation; endoplasmic reticulum membrane; intracellular mRNA localization; meiotic telomere clustering; nuclear membrane; pheromone-dependent signal transduction involved in conjugation with cellular fusion; polysome IPR004087; IPR004088; Protein SCP160 (Protein HX) SCP160 HX YJL080C J1017 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR34573_c0_g2_i1 O19048 PCBP1_RABIT 7.00E-07 GO:0003723; GO:0005634; GO:0030529; GO:0003697 RNA binding; nucleus; ribonucleoprotein complex; single-stranded DNA binding IPR004087; IPR004088; Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) PCBP1 Oryctolagus cuniculus (Rabbit) TR34573_c0_g3_i1 Q00341 VIGLN_HUMAN 0 GO:0003723; GO:0008203; GO:0005737; GO:0034364; GO:0008289; GO:0006869; GO:0005634; GO:0005886 RNA binding; cholesterol metabolic process; cytoplasm; high-density lipoprotein particle; lipid binding; lipid transport; nucleus; plasma membrane IPR004087; IPR004088; Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) HDLBP HBP VGL Homo sapiens (Human) TR34573_c0_g4_i2 Q9Y2W6 TDRKH_HUMAN 3.00E-06 GO:0043046; GO:0003723; GO:0030154; GO:0009566; GO:0031047; GO:0007140; GO:0005739; GO:0071546; GO:0071547; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; RNA binding; cell differentiation; fertilization; gene silencing by RNA; male meiosis; mitochondrion; pi-body; piP-body; piRNA metabolic process; spermatogenesis IPR004087; IPR004088; IPR002999; Tudor and KH domain-containing protein (Tudor domain-containing protein 2) TDRKH TDRD2 Homo sapiens (Human) TR34574_c0_g1_i1 Q9W625 IMPCT_XENLA 1.00E-80 GO:0005737; GO:0006417 cytoplasm; regulation of translation IPR023582; IPR001498; IPR020568; IPR006575; IPR016135; Protein IMPACT (Imprinted and ancient gene protein homolog) (Ximpact) impact Xenopus laevis (African clawed frog) TR34574_c0_g1_i2 Q9W625 IMPCT_XENLA 4.00E-84 GO:0005737; GO:0006417 cytoplasm; regulation of translation IPR023582; IPR001498; IPR020568; IPR006575; IPR016135; Protein IMPACT (Imprinted and ancient gene protein homolog) (Ximpact) impact Xenopus laevis (African clawed frog) TR34575_c6_g2_i1 Q922J3 CLIP1_MOUSE 9.00E-31 GO:0005813; GO:0005881; GO:0030659; GO:0044354; GO:0008017; GO:0001578; GO:0035371; GO:0003676; GO:0031116; GO:0001726; GO:0006810; GO:0008270 centrosome; cytoplasmic microtubule; cytoplasmic vesicle membrane; macropinosome; microtubule binding; microtubule bundle formation; microtubule plus end; nucleic acid binding; positive regulation of microtubule polymerization; ruffle; transport; zinc ion binding IPR000938; IPR001878; CAP-Gly domain-containing linker protein 1 (Restin) Clip1 Kiaa4046 Rsn Mus musculus (Mouse) TR34577_c0_g1_i1 P54279 PMS2_MOUSE 2.00E-115 GO:0005524; GO:0016887; GO:0032389; GO:0032407; GO:0004519; GO:0006298; GO:0030983; GO:0090305; GO:0007131; GO:0003697; GO:0016446; GO:0016447 ATP binding; ATPase activity; MutLalpha complex; MutSalpha complex binding; endonuclease activity; mismatch repair; mismatched DNA binding; nucleic acid phosphodiester bond hydrolysis; reciprocal meiotic recombination; single-stranded DNA binding; somatic hypermutation of immunoglobulin genes; somatic recombination of immunoglobulin gene segments IPR013507; IPR014762; IPR002099; IPR003594; IPR014790; IPR020568; IPR014721; Mismatch repair endonuclease PMS2 (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) Pms2 Mus musculus (Mouse) TR34577_c1_g1_i1 Q9BW60 ELOV1_HUMAN 3.00E-15 GO:0009922; GO:0034625; GO:0019367; GO:0030176; GO:0035338; GO:0030148; GO:0019432; GO:0042761 O75832; Q6IBS0 "fatty acid elongase activity; fatty acid elongation, monounsaturated fatty acid; fatty acid elongation, saturated fatty acid; integral to endoplasmic reticulum membrane; long-chain fatty-acyl-CoA biosynthetic process; sphingolipid biosynthetic process; triglyceride biosynthetic process; very long-chain fatty acid biosynthetic process" IPR002076; Elongation of very long chain fatty acids protein 1 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL1) (ELOVL fatty acid elongase 1) (ELOVL FA elongase 1) (Very-long-chain 3-oxoacyl-CoA synthase 1) ELOVL1 SSC1 CGI-88 Homo sapiens (Human) TR34579_c1_g2_i1 P38287 CSH1_YEAST 2.00E-30 GO:0006688; GO:0016021; GO:0000030; GO:0005774 P35206 glycosphingolipid biosynthetic process; integral to membrane; mannosyltransferase activity; vacuolar membrane IPR007577; Mannosyl phosphorylinositol ceramide synthase CSH1 (EC 2.-.-.-) (CSG1/SUR1 homolog 1) CSH1 YBR161W YBR1212 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR34579_c1_g2_i2 Q10323 IMT3_SCHPO 4.00E-31 GO:0005794; GO:0033106; GO:0007038; GO:0006897; GO:0005783; GO:0005789; GO:0016021; GO:0051999; GO:0000030; GO:0032588 Golgi apparatus; cis-Golgi network membrane; endocytosed protein transport to vacuole; endocytosis; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; mannosyl-inositol phosphorylceramide biosynthetic process; mannosyltransferase activity; trans-Golgi network membrane IPR007577; Inositol phosphoceramide mannosyltransferase 3 (EC 2.4.-.-) (IPC mannosyltransferase 3) SPAC17G8.11c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR34582_c2_g1_i2 Q67XX3 FB252_ARATH 3.00E-10 GO:0000987; GO:0043985; GO:0005634; GO:0010030 core promoter proximal region sequence-specific DNA binding; histone H4-R3 methylation; nucleus; positive regulation of seed germination IPR001810; IPR003347; F-box protein At5g06550 At5g06550 F15M7.8 Arabidopsis thaliana (Mouse-ear cress) TR34586_c0_g1_i3 Q8K2J9 BTBD6_MOUSE 5.00E-45 GO:0000932 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6 Btbd6 Mus musculus (Mouse) TR34586_c0_g1_i4 Q8K2J9 BTBD6_MOUSE 4.00E-45 GO:0000932 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6 Btbd6 Mus musculus (Mouse) TR34587_c0_g1_i1 Q9BY84 DUS16_HUMAN 3.00E-18 GO:0017017; GO:0045204; GO:0045209; GO:0005737; GO:0016023; GO:0005634; GO:0035335; GO:0004725 "MAP kinase tyrosine/serine/threonine phosphatase activity; MAPK export from nucleus; MAPK phosphatase export from nucleus, leptomycin B sensitive; cytoplasm; cytoplasmic membrane-bounded vesicle; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity" IPR000340; IPR020422; IPR024950; IPR008343; IPR001763; IPR000387; IPR016130; Dual specificity protein phosphatase 16 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7) DUSP16 KIAA1700 MKP7 Homo sapiens (Human) TR34587_c0_g1_i2 Q5BIP9 DUS18_BOVIN 3.00E-47 GO:0017017; GO:0005743; GO:0005634; GO:0035335; GO:0004725; GO:0008138 MAP kinase tyrosine/serine/threonine phosphatase activity; mitochondrial inner membrane; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR020417; IPR020420; IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Dual specificity protein phosphatase 18 (EC 3.1.3.16) (EC 3.1.3.48) DUSP18 Bos taurus (Bovine) TR34587_c0_g1_i3 Q9H596 DUS21_HUMAN 1.00E-42 GO:0017017; GO:0005737; GO:0005743; GO:0005634; GO:0004725; GO:0008138 MAP kinase tyrosine/serine/threonine phosphatase activity; cytoplasm; mitochondrial inner membrane; nucleus; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR020417; IPR020420; IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Dual specificity protein phosphatase 21 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular weight dual specificity phosphatase 21) (LMW-DSP21) DUSP21 LMWDSP21 Homo sapiens (Human) TR34590_c0_g1_i1 P40261 NNMT_HUMAN 2.00E-35 GO:0005829; GO:0008112; GO:0031100; GO:0042493; GO:0010243; GO:0044281; GO:0006805 cytosol; nicotinamide N-methyltransferase activity; organ regeneration; response to drug; response to organonitrogen compound; small molecule metabolic process; xenobiotic metabolic process IPR025818; IPR025820; IPR000940; Nicotinamide N-methyltransferase (EC 2.1.1.1) NNMT Homo sapiens (Human) TR34590_c0_g1_i2 O97972 INMT_RABIT 1.00E-33 GO:0030748; GO:0009308; GO:0005829; GO:0009636; GO:0004790 amine N-methyltransferase activity; amine metabolic process; cytosol; response to toxic substance; thioether S-methyltransferase activity IPR025817; IPR025820; IPR000940; Indolethylamine N-methyltransferase (Indolamine N-methyltransferase) (EC 2.1.1.49) (EC 2.1.1.96) (Aromatic alkylamine N-methyltransferase) (Amine N-methyltransferase) (Arylamine N-methyltransferase) (Thioether S-methyltransferase) INMT Oryctolagus cuniculus (Rabbit) TR34590_c0_g1_i3 O55239 NNMT_MOUSE 1.00E-36 GO:0005737; GO:0008112 cytoplasm; nicotinamide N-methyltransferase activity IPR025818; IPR025820; IPR000940; Nicotinamide N-methyltransferase (EC 2.1.1.1) Nnmt Mus musculus (Mouse) TR34591_c3_g1_i1 P69451 LCFA_ECOLI 2.00E-07 GO:0005524; GO:0006637; GO:0005829; GO:0006635; GO:0009898; GO:0004467; GO:0070538; GO:0008654 ATP binding; acyl-CoA metabolic process; cytosol; fatty acid beta-oxidation; internal side of plasma membrane; long-chain fatty acid-CoA ligase activity; oleic acid binding; phospholipid biosynthetic process IPR025110; IPR020845; IPR000873; Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) (Long-chain acyl-CoA synthetase) (Acyl-CoA synthetase) fadD oldD b1805 JW1794 Escherichia coli (strain K12) TR34591_c4_g1_i2 O14975 S27A2_HUMAN 3.00E-98 GO:0005524; GO:0006699; GO:0005788; GO:0001561; GO:0006635; GO:0015245; GO:0030176; GO:0005779; GO:0044539; GO:0004467; GO:0097089; GO:0005739; GO:0050197; GO:0070251; GO:0042760; GO:0031957 ATP binding; bile acid biosynthetic process; endoplasmic reticulum lumen; fatty acid alpha-oxidation; fatty acid beta-oxidation; fatty acid transporter activity; integral to endoplasmic reticulum membrane; integral to peroxisomal membrane; long-chain fatty acid import; long-chain fatty acid-CoA ligase activity; methyl-branched fatty acid metabolic process; mitochondrion; phytanate-CoA ligase activity; pristanate-CoA ligase activity; very long-chain fatty acid catabolic process; very long-chain fatty acid-CoA ligase activity IPR025110; IPR020845; IPR000873; "Very long-chain acyl-CoA synthetase (VLACS) (VLCS) (EC 6.2.1.-) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 2) (THCA-CoA ligase) (Very long-chain-fatty-acid-CoA ligase)" SLC27A2 ACSVL1 FACVL1 FATP2 VLACS Homo sapiens (Human) TR34593_c0_g1_i2 Q9Y6V7 DDX49_HUMAN 0 GO:0005524; GO:0008026; GO:0003723 ATP binding; ATP-dependent helicase activity; RNA binding IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX49 (EC 3.6.4.13) (DEAD box protein 49) DDX49 Homo sapiens (Human) TR34593_c0_g1_i3 Q4P3W3 DBP10_USTMA 2.00E-29 GO:0005524; GO:0008026; GO:0003723; GO:0005730; GO:0006364 ATP binding; ATP-dependent helicase activity; RNA binding; nucleolus; rRNA processing IPR012541; IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DBP10 (EC 3.6.4.13) DBP10 UM05200 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR34593_c0_g1_i4 P0CR02 DBP8_CRYNJ 8.00E-113 GO:0005524; GO:0008026; GO:0003723; GO:0005730; GO:0006364 ATP binding; ATP-dependent helicase activity; RNA binding; nucleolus; rRNA processing IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DBP8 (EC 3.6.4.13) DBP8 CNA01540 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR34593_c0_g1_i5 Q9Y6V7 DDX49_HUMAN 0 GO:0005524; GO:0008026; GO:0003723 ATP binding; ATP-dependent helicase activity; RNA binding IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX49 (EC 3.6.4.13) (DEAD box protein 49) DDX49 Homo sapiens (Human) TR34595_c2_g1_i2 Q6DCG9 S35A5_XENLA 4.00E-20 GO:0000139; GO:0016021; GO:0005351 Golgi membrane; integral to membrane; sugar:hydrogen symporter activity IPR007271; IPR021189; Probable UDP-sugar transporter protein SLC35A5 (Solute carrier family 35 member A5) slc35a5 Xenopus laevis (African clawed frog) TR34595_c2_g1_i3 A4IHW3 S35A4_XENTR 8.00E-70 GO:0000139; GO:0016021; GO:0005338; GO:0015780; GO:0005351 Golgi membrane; integral to membrane; nucleotide-sugar transmembrane transporter activity; nucleotide-sugar transport; sugar:hydrogen symporter activity IPR007271; IPR004689; Probable UDP-sugar transporter protein SLC35A4 (Solute carrier family 35 member A4) slc35a4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34597_c0_g1_i6 P0DJ46 VPI1B_LYCMC 5.00E-16 GO:0044562; GO:0033644; GO:0004867 envenomation resulting in negative regulation of voltage-gated potassium channel activity in other organism; host cell membrane; serine-type endopeptidase inhibitor activity IPR002223; Protease inhibitor LmKTT-1a (SdPII) Lychas mucronatus (Chinese swimming scorpion) TR34597_c1_g2_i1 Q148C8 MIEN1_BOVIN 1.00E-14 GO:0006915; GO:0045454; GO:0005829; GO:0031235; GO:0043066; GO:0030335; GO:0051491; GO:0008430 apoptotic process; cell redox homeostasis; cytosol; intrinsic to internal side of plasma membrane; negative regulation of apoptotic process; positive regulation of cell migration; positive regulation of filopodium assembly; selenium binding IPR011893; IPR012336; Migration and invasion enhancer 1 MIEN1 RDX12 Bos taurus (Bovine) TR34598_c0_g1_i1 Q9NXZ2 DDX43_HUMAN 0 GO:0005524; GO:0004004; GO:0003723; GO:0005622 ATP binding; ATP-dependent RNA helicase activity; RNA binding; intracellular IPR011545; IPR014001; IPR001650; IPR004087; IPR004088; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX43 (EC 3.6.4.13) (Cancer/testis antigen 13) (CT13) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen) DDX43 HAGE Homo sapiens (Human) TR34599_c0_g1_i1 P33189 YHXA_BACSU 2.00E-23 GO:0006071; GO:0030170; GO:0008483 glycerol metabolic process; pyridoxal phosphate binding; transaminase activity IPR005814; IPR015424; IPR015421; IPR015422; Uncharacterized aminotransferase YhxA (EC 2.6.-.-) yhxA BSU09260 Bacillus subtilis (strain 168) TR34599_c0_g2_i2 Q6DEB1 AT2L1_XENLA 6.00E-115 GO:0050459; GO:0008152; GO:0005739; GO:0030170; GO:0008483 ethanolamine-phosphate phospho-lyase activity; metabolic process; mitochondrion; pyridoxal phosphate binding; transaminase activity IPR005814; IPR015424; IPR015421; IPR015422; Ethanolamine-phosphate phospho-lyase (EC 4.2.3.2) (Alanine--glyoxylate aminotransferase 2-like 1) etnppl agxt2l1 Xenopus laevis (African clawed frog) TR34599_c0_g2_i3 Q6DEB1 AT2L1_XENLA 5.00E-88 GO:0050459; GO:0008152; GO:0005739; GO:0030170; GO:0008483 ethanolamine-phosphate phospho-lyase activity; metabolic process; mitochondrion; pyridoxal phosphate binding; transaminase activity IPR005814; IPR015424; IPR015421; IPR015422; Ethanolamine-phosphate phospho-lyase (EC 4.2.3.2) (Alanine--glyoxylate aminotransferase 2-like 1) etnppl agxt2l1 Xenopus laevis (African clawed frog) TR34600_c10_g1_i1 O15492 RGS16_HUMAN 3.00E-22 GO:0005096; GO:0005516; GO:0005737; GO:0005886; GO:0008277; GO:0038032; GO:0007601 GTPase activator activity; calmodulin binding; cytoplasm; plasma membrane; regulation of G-protein coupled receptor protein signaling pathway; termination of G-protein coupled receptor signaling pathway; visual perception IPR024066; IPR016137; IPR000342; Regulator of G-protein signaling 16 (RGS16) (A28-RGS14P) (Retinal-specific RGS) (RGS-r) (hRGS-r) (Retinally abundant regulator of G-protein signaling) RGS16 RGSR Homo sapiens (Human) TR34600_c10_g1_i2 O43566 RGS14_HUMAN 8.00E-32 GO:0005092; GO:0005096; GO:0016605; GO:0030054; GO:0005813; GO:0007059; GO:0005737; GO:0043197; GO:0045111; GO:0007616; GO:0060291; GO:0005874; GO:0008017; GO:0007067; GO:0070373; GO:0043407; GO:0031914; GO:0016604; GO:0006913; GO:0005886; GO:0048008; GO:0050769; GO:0014069; GO:0045211; GO:0030159; GO:0005057; GO:0043620; GO:0008277; GO:0006979; GO:0007051; GO:0000922; GO:0038032; GO:0008542; GO:0010070 GDP-dissociation inhibitor activity; GTPase activator activity; PML body; cell junction; centrosome; chromosome segregation; cytoplasm; dendritic spine; intermediate filament cytoskeleton; long-term memory; long-term synaptic potentiation; microtubule; microtubule binding; mitosis; negative regulation of ERK1 and ERK2 cascade; negative regulation of MAP kinase activity; negative regulation of synaptic plasticity; nuclear body; nucleocytoplasmic transport; plasma membrane; platelet-derived growth factor receptor signaling pathway; positive regulation of neurogenesis; postsynaptic density; postsynaptic membrane; receptor signaling complex scaffold activity; receptor signaling protein activity; regulation of DNA-dependent transcription in response to stress; regulation of G-protein coupled receptor protein signaling pathway; response to oxidative stress; spindle organization; spindle pole; termination of G-protein coupled receptor signaling pathway; visual learning; zygote asymmetric cell division IPR003109; IPR003116; IPR024066; IPR016137; IPR000342; Regulator of G-protein signaling 14 (RGS14) RGS14 Homo sapiens (Human) TR34600_c6_g1_i1 Q6ZM86 GRD2I_DANRE 1.00E-07 GO:0030054; GO:0045211 cell junction; postsynaptic membrane IPR015425; IPR001478; "Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1)" grid2ip si:ch211-147h1.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR34601_c0_g1_i1 Q2KHS5 MOG2A_XENLA 8.00E-33 GO:0003846; GO:0005789; GO:0006071; GO:0016021; GO:0019432 2-acylglycerol O-acyltransferase activity; endoplasmic reticulum membrane; glycerol metabolic process; integral to membrane; triglyceride biosynthetic process IPR007130; Glycerolipid metabolism; triacylglycerol biosynthesis. 2-acylglycerol O-acyltransferase 2-A (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 2-A) (MGAT2-A) (Monoacylglycerol O-acyltransferase 2-A) mogat2-a Xenopus laevis (African clawed frog) TR34601_c0_g1_i2 Q91ZV4 MOGT1_MOUSE 6.00E-24 GO:0003846; GO:0004144; GO:0006651; GO:0005783; GO:0005789; GO:0006071; GO:0016021; GO:0016020; GO:0019432 2-acylglycerol O-acyltransferase activity; diacylglycerol O-acyltransferase activity; diacylglycerol biosynthetic process; endoplasmic reticulum; endoplasmic reticulum membrane; glycerol metabolic process; integral to membrane; membrane; triglyceride biosynthetic process IPR007130; Glycerolipid metabolism; triacylglycerol biosynthesis. 2-acylglycerol O-acyltransferase 1 (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 1) (MGAT1) (Diacylglycerol acyltransferase 2-like protein 1) (Monoacylglycerol O-acyltransferase 1) Mogat1 Dgat2l1 Mus musculus (Mouse) TR34601_c0_g1_i3 Q6IED9 DG2L7_HUMAN 2.00E-12 GO:0006629; GO:0016747 "lipid metabolic process; transferase activity, transferring acyl groups other than amino-acyl groups" IPR007130; Putative diacylglycerol O-acyltransferase 2-like protein DGAT2L7P (EC 2.3.1.-) (Diacylglycerol O-acyltransferase 2-like 7 pseudogene) DGAT2L7P Homo sapiens (Human) TR34601_c0_g2_i1 Q80W94 MOGT2_MOUSE 7.00E-55 GO:0003846; GO:0016407; GO:0006651; GO:0005783; GO:0005789; GO:0006071; GO:0016021; GO:0050892; GO:0046462; GO:0019432 2-acylglycerol O-acyltransferase activity; acetyltransferase activity; diacylglycerol biosynthetic process; endoplasmic reticulum; endoplasmic reticulum membrane; glycerol metabolic process; integral to membrane; intestinal absorption; monoacylglycerol metabolic process; triglyceride biosynthetic process IPR007130; Glycerolipid metabolism; triacylglycerol biosynthesis. 2-acylglycerol O-acyltransferase 2 (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 2) (MGAT2) (Diacylglycerol acyltransferase 2-like protein 5) (Monoacylglycerol O-acyltransferase 1-like) (Monoacylglycerol O-acyltransferase 2) Mogat2 Dgat2l5 Mgat1l Mus musculus (Mouse) TR34602_c2_g1_i1 Q642A0 PDRG1_RAT 3.00E-26 GO:0016272; GO:0006457 prefoldin complex; protein folding IPR002777; IPR009053; p53 and DNA damage-regulated protein 1 Pdrg1 Rattus norvegicus (Rat) TR34604_c1_g1_i1 P35003 CTRL_HALRU 2.00E-141 GO:0005615; GO:0006508; GO:0004252 extracellular space; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Chymotrypsin-like serine proteinase (EC 3.4.21.-) Haliotis rufescens (California red abalone) TR34604_c1_g1_i3 P04187 GRAB_MOUSE 6.00E-29 GO:0001913; GO:0019835; GO:0044194; GO:0005829; GO:0008626; GO:0006508; GO:0004252; GO:0008236 T cell mediated cytotoxicity; cytolysis; cytolytic granule; cytosol; granzyme-mediated apoptotic signaling pathway; proteolysis; serine-type endopeptidase activity; serine-type peptidase activity IPR001254; IPR018114; IPR001314; IPR009003; "Granzyme B(G,H) (EC 3.4.21.79) (CTLA-1) (Cytotoxic cell protease 1) (CCP1) (Fragmentin-2)" Gzmb Ctla-1 Ctla1 Mus musculus (Mouse) TR34605_c1_g1_i1 F1MBP6 KLHL3_BOVIN 8.00E-39 GO:0031463; GO:0005856; GO:0005829; GO:0072156; GO:0050801; GO:0070936; GO:0042787; GO:0070294 Cul3-RING ubiquitin ligase complex; cytoskeleton; cytosol; distal tubule morphogenesis; ion homeostasis; protein K48-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; renal sodium ion absorption IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 3 KLHL3 Bos taurus (Bovine) TR34605_c1_g1_i2 Q6ZPT1 KLHL9_MOUSE 8.00E-65 GO:0031463; GO:0000910; GO:0030496; GO:0007067; GO:0016567; GO:0004842 Cul3-RING ubiquitin ligase complex; cytokinesis; midbody; mitosis; protein ubiquitination; ubiquitin-protein ligase activity IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 9 Klhl9 Kiaa1354 Mus musculus (Mouse) TR34605_c1_g1_i3 A6QQY2 KLH13_BOVIN 4.00E-62 GO:0031463; GO:0000910; GO:0007067; GO:0016567 Cul3-RING ubiquitin ligase complex; cytokinesis; mitosis; protein ubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 13 KLHL13 Bos taurus (Bovine) TR34607_c0_g1_i10 Q4R8A8 TMM97_MACFA 7.00E-25 GO:0042632; GO:0016021; GO:0005764; GO:0031965; GO:0005886; GO:0005791 cholesterol homeostasis; integral to membrane; lysosome; nuclear membrane; plasma membrane; rough endoplasmic reticulum IPR016964; Transmembrane protein 97 Tmem97 QtsA-12948 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR34607_c0_g1_i6 Q4R8A8 TMM97_MACFA 5.00E-39 GO:0042632; GO:0016021; GO:0005764; GO:0031965; GO:0005886; GO:0005791 cholesterol homeostasis; integral to membrane; lysosome; nuclear membrane; plasma membrane; rough endoplasmic reticulum IPR016964; Transmembrane protein 97 Tmem97 QtsA-12948 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR34607_c0_g1_i8 Q12155 YL050_YEAST 2.00E-07 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR016964; Uncharacterized membrane protein YLR050C YLR050C L2125 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR34608_c2_g1_i3 Q54SR8 SGMC_DICDI 1.00E-54 GO:0046513; GO:0005615; GO:0016798; GO:0006685; GO:0004767 "ceramide biosynthetic process; extracellular space; hydrolase activity, acting on glycosyl bonds; sphingomyelin catabolic process; sphingomyelin phosphodiesterase activity" IPR017064; IPR004843; Sphingomyelinase phosphodiesterase C (EC 3.1.4.-) (ASM-like phosphodiesterase C) sgmC DDB_G0282265 Dictyostelium discoideum (Slime mold) TR34608_c2_g1_i4 P58242 ASM3B_MOUSE 9.00E-78 GO:0005615; GO:0016798; GO:0006685; GO:0004767 "extracellular space; hydrolase activity, acting on glycosyl bonds; sphingomyelin catabolic process; sphingomyelin phosphodiesterase activity" IPR017064; IPR004843; Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-) Smpdl3b Asml3b Mus musculus (Mouse) TR34609_c1_g2_i2 Q86JP3 RAB5A_DICDI 1.00E-47 GO:0005525; GO:0010008; GO:0005886; GO:0015031; GO:0007264 GTP binding; endosome membrane; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-5A rab5A DDB_G0271984 Dictyostelium discoideum (Slime mold) TR34613_c2_g1_i1 A4IF63 TRIM2_BOVIN 1.00E-37 GO:0005737; GO:0043523; GO:0004842; GO:0008270 cytoplasm; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) TR34613_c2_g1_i2 O75382 TRIM3_HUMAN 7.00E-36 GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0015031; GO:0008270 cytoplasm; early endosome; nervous system development; protein C-terminus binding; protein transport; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) TR34619_c1_g2_i1 P49842 STK19_HUMAN 4.00E-62 GO:0005524; GO:0005634; GO:0004674 ATP binding; nucleus; protein serine/threonine kinase activity IPR018865; Serine/threonine-protein kinase 19 (EC 2.7.11.1) (Protein G11) (Protein RP1) STK19 G11 RP1 Homo sapiens (Human) TR34620_c0_g1_i1 Q0V8F1 CORO7_BOVIN 2.00E-112 GO:0005794; GO:0000139; GO:0016023; GO:0005829 Golgi apparatus; Golgi membrane; cytoplasmic membrane-bounded vesicle; cytosol IPR027331; IPR015505; IPR015049; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; Coronin-7 (Crn7) CORO7 Bos taurus (Bovine) TR34620_c0_g1_i2 P57737 CORO7_HUMAN 5.00E-35 GO:0005794; GO:0000139; GO:0016023; GO:0005829; GO:0016021 Q61471 Golgi apparatus; Golgi membrane; cytoplasmic membrane-bounded vesicle; cytosol; integral to membrane IPR027331; IPR015505; IPR015049; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog) CORO7 Homo sapiens (Human) TR34621_c2_g1_i1 Q8R0N9 ZDHC1_MOUSE 2.00E-48 GO:0016021; GO:0016409; GO:0018345; GO:0008270 integral to membrane; palmitoyltransferase activity; protein palmitoylation; zinc ion binding IPR001594; Probable palmitoyltransferase ZDHHC1 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 1) (DHHC-1) Zdhhc1 Mus musculus (Mouse) TR34622_c1_g2_i3 O17482 TIM_DROVI 1.00E-53 GO:0005634; GO:0048471; GO:0048511 nucleus; perinuclear region of cytoplasm; rhythmic process IPR006906; Protein timeless tim Drosophila virilis (Fruit fly) TR34622_c1_g3_i1 O17482 TIM_DROVI 1.00E-19 GO:0005634; GO:0048471; GO:0048511 nucleus; perinuclear region of cytoplasm; rhythmic process IPR006906; Protein timeless tim Drosophila virilis (Fruit fly) TR34624_c4_g1_i1 Q0VD26 MORN4_BOVIN 1.00E-07 IPR003409; MORN repeat-containing protein 4 MORN4 Bos taurus (Bovine) TR34624_c4_g1_i2 Q5PPV3 MORN3_XENLA 3.00E-95 IPR003409; MORN repeat-containing protein 3 morn3 Xenopus laevis (African clawed frog) TR34626_c0_g1_i1 O08629 TIF1B_RAT 4.00E-06 GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0005719; GO:0005720; GO:0005654; GO:0005634; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006351; GO:0004842; GO:0008270 "DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; nucleus; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (Nuclear corepressor KAP-1) (Tripartite motif-containing protein 28) Trim28 Kap1 Tif1b Rattus norvegicus (Rat) TR34626_c0_g1_i2 Q9UPN9 TRI33_HUMAN 9.00E-06 GO:0003677; GO:0030514; GO:0000122; GO:0005654; GO:0017015; GO:0006367; GO:0007179; GO:0004842; GO:0008270 Q15796; Q13485 DNA binding; negative regulation of BMP signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; regulation of transforming growth factor beta receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) TRIM33 KIAA1113 RFG7 TIF1G Homo sapiens (Human) TR34628_c1_g4_i1 P49791 NU153_RAT 1.00E-23 GO:0003677; GO:0051028; GO:0046832; GO:0042405; GO:0005652; GO:0031965; GO:0051292; GO:0044615; GO:0005487; GO:0043495; GO:0015031; GO:0017056; GO:0008270 DNA binding; mRNA transport; negative regulation of RNA export from nucleus; nuclear inclusion body; nuclear lamina; nuclear membrane; nuclear pore complex assembly; nuclear pore nuclear basket; nucleocytoplasmic transporter activity; protein anchor; protein transport; structural constituent of nuclear pore; zinc ion binding IPR026054; IPR013913; IPR018892; IPR001876; Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) Nup153 Rattus norvegicus (Rat) TR34629_c0_g1_i1 Q5GH73 XKR6_HUMAN 1.00E-22 GO:0016021 integral to membrane IPR018629; XK-related protein 6 XKR6 C8orf21 C8orf5 C8orf7 XRG6 Homo sapiens (Human) TR3463_c0_g1_i1 Q8K0U4 HS12A_MOUSE 1.00E-27 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR34630_c12_g1_i1 Q5SXM1 ZN678_HUMAN 2.00E-18 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 678 ZNF678 Homo sapiens (Human) TR34630_c4_g1_i1 Q8TF68 ZN384_HUMAN 7.00E-13 GO:0005925; GO:0046872; GO:0006913; GO:0005634; GO:0050714; GO:0045944; GO:0043565; GO:0006351 "focal adhesion; metal ion binding; nucleocytoplasmic transport; nucleus; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 384 (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (Trinucleotide repeat-containing gene 1 protein) ZNF384 CAGH1 CIZ NMP4 TNRC1 Homo sapiens (Human) TR34632_c2_g2_i1 P82094 TMF1_HUMAN 3.00E-48 GO:0003677; GO:0005794; GO:0000139; GO:0001675; GO:0071407; GO:0042742; GO:0008584; GO:0010629; GO:0005634; GO:0001819; GO:0061136; GO:0006355; GO:0030317; GO:0007289; GO:0003712; GO:0006366 P04150 "DNA binding; Golgi apparatus; Golgi membrane; acrosome assembly; cellular response to organic cyclic compound; defense response to bacterium; male gonad development; negative regulation of gene expression; nucleus; positive regulation of cytokine production; regulation of proteasomal protein catabolic process; regulation of transcription, DNA-dependent; sperm motility; spermatid nucleus differentiation; transcription cofactor activity; transcription from RNA polymerase II promoter" IPR022092; IPR022091; TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) TMF1 ARA160 Homo sapiens (Human) TR34635_c0_g2_i1 Q5RBU8 ROA2_PONAB 4.00E-12 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0005654; GO:0000166; GO:0030529; GO:0005681 RNA binding; RNA splicing; cytoplasm; mRNA processing; nucleoplasm; nucleotide binding; ribonucleoprotein complex; spliceosomal complex IPR012677; IPR000504; Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) HNRNPA2B1 HNRPA2B1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34635_c0_g2_i2 Q9VVE5 MSIR6_DROME 2.00E-22 GO:0005737; GO:0000166; GO:0008266; GO:0005844; GO:0048864 cytoplasm; nucleotide binding; poly(U) RNA binding; polysome; stem cell development IPR012677; IPR000504; RNA-binding protein Musashi homolog Rbp6 Rbp6 RRM6 CG32169 Drosophila melanogaster (Fruit fly) TR34635_c0_g4_i4 P48809 RB27C_DROME 7.00E-19 GO:0007411; GO:0007298; GO:0005737; GO:0046331; GO:0003730; GO:0048027; GO:0007319; GO:0005654; GO:0000166; GO:0045451; GO:0045727; GO:0043234; GO:0048024; GO:0030529; GO:0003697 "axon guidance; border follicle cell migration; cytoplasm; lateral inhibition; mRNA 3'-UTR binding; mRNA 5'-UTR binding; negative regulation of oskar mRNA translation; nucleoplasm; nucleotide binding; pole plasm oskar mRNA localization; positive regulation of translation; protein complex; regulation of mRNA splicing, via spliceosome; ribonucleoprotein complex; single-stranded DNA binding" IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein 27C (Hrb27-C) (HRP48.1) (hnRNP 48) Hrb27C hrp48 Rbp7 CG10377 Drosophila melanogaster (Fruit fly) TR34642_c0_g1_i1 Q54EP3 POP5_DICDI 2.00E-12 GO:0005655; GO:0006364; GO:0000172; GO:0004526; GO:0008033 nucleolar ribonuclease P complex; rRNA processing; ribonuclease MRP complex; ribonuclease P activity; tRNA processing IPR016819; IPR002759; Probable ribonuclease P/MRP protein subunit POP5 (EC 3.1.26.5) pop5 DDB_G0291662 Dictyostelium discoideum (Slime mold) TR34642_c0_g1_i5 Q9UU90 POP5_SCHPO 2.00E-10 GO:0005783; GO:0005655; GO:0006364; GO:0000172; GO:0004526; GO:0008033 endoplasmic reticulum; nucleolar ribonuclease P complex; rRNA processing; ribonuclease MRP complex; ribonuclease P activity; tRNA processing IPR002759; Ribonucleases P/MRP protein subunit POP5 (EC 3.1.26.5) SPCC830.09c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR34642_c0_g1_i6 Q1JQ92 POP5_BOVIN 2.00E-26 GO:0005730; GO:0004526; GO:0008033 nucleolus; ribonuclease P activity; tRNA processing IPR016819; IPR002759; Ribonuclease P/MRP protein subunit POP5 (EC 3.1.26.5) POP5 Bos taurus (Bovine) TR34643_c0_g1_i1 Q6VVD7 SOX8_XENLA 3.00E-64 GO:0003677; GO:0014029; GO:0005634; GO:0006355; GO:0006351 "DNA binding; neural crest formation; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009071; IPR022151; Transcription factor Sox-8 sox8 Xenopus laevis (African clawed frog) TR34646_c3_g1_i1 Q28DS0 SAE1_XENTR 3.00E-118 GO:0016874; GO:0005634; GO:0008022; GO:0016925; GO:0008641 ligase activity; nucleus; protein C-terminus binding; protein sumoylation; small protein activating enzyme activity IPR009036; IPR016040; IPR000594; IPR000011; Protein modification; protein sumoylation. SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) sae1 uble1a TGas081c19.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34646_c3_g1_i2 Q28DS0 SAE1_XENTR 2.00E-118 GO:0016874; GO:0005634; GO:0008022; GO:0016925; GO:0008641 ligase activity; nucleus; protein C-terminus binding; protein sumoylation; small protein activating enzyme activity IPR009036; IPR016040; IPR000594; IPR000011; Protein modification; protein sumoylation. SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) sae1 uble1a TGas081c19.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34648_c4_g2_i1 Q5VUA4 ZN318_HUMAN 2.00E-34 GO:0005737; GO:0007126; GO:0003676; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "cytoplasm; meiosis; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR015880; IPR003604; Zinc finger protein 318 (Endocrine regulatory protein) ZNF318 HRIHFB2436 Homo sapiens (Human) TR34649_c0_g2_i2 P09874 PARP1_HUMAN 0 GO:0003677; GO:0042769; GO:0051287; GO:0003950; GO:0006284; GO:0032869; GO:0006302; GO:0000122; GO:0005635; GO:0005730; GO:0005654; GO:0016540; GO:0070212; GO:0040009; GO:0000723; GO:0005667; GO:0006367; GO:0007179; GO:0008270 Itself; Q8IW19; Q7Z2E3; P49715; Q01094; P11308; Q9Y530; Q8N2W9; O95863; Q02085; P63165; P04637; P0CG48; Q14191; P18887; Q2M1K9 "DNA binding; DNA damage response, detection of DNA damage; NAD binding; NAD+ ADP-ribosyltransferase activity; base-excision repair; cellular response to insulin stimulus; double-strand break repair; negative regulation of transcription from RNA polymerase II promoter; nuclear envelope; nucleolus; nucleoplasm; protein autoprocessing; protein poly-ADP-ribosylation; regulation of growth rate; telomere maintenance; transcription factor complex; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; zinc ion binding" IPR001357; IPR008288; IPR012982; IPR012317; IPR004102; IPR008893; IPR001510; Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) PARP1 ADPRT PPOL Homo sapiens (Human) TR34649_c0_g2_i3 P09874 PARP1_HUMAN 0 GO:0003677; GO:0042769; GO:0051287; GO:0003950; GO:0006284; GO:0032869; GO:0006302; GO:0000122; GO:0005635; GO:0005730; GO:0005654; GO:0016540; GO:0070212; GO:0040009; GO:0000723; GO:0005667; GO:0006367; GO:0007179; GO:0008270 Itself; Q8IW19; Q7Z2E3; P49715; Q01094; P11308; Q9Y530; Q8N2W9; O95863; Q02085; P63165; P04637; P0CG48; Q14191; P18887; Q2M1K9 "DNA binding; DNA damage response, detection of DNA damage; NAD binding; NAD+ ADP-ribosyltransferase activity; base-excision repair; cellular response to insulin stimulus; double-strand break repair; negative regulation of transcription from RNA polymerase II promoter; nuclear envelope; nucleolus; nucleoplasm; protein autoprocessing; protein poly-ADP-ribosylation; regulation of growth rate; telomere maintenance; transcription factor complex; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; zinc ion binding" IPR001357; IPR008288; IPR012982; IPR012317; IPR004102; IPR008893; IPR001510; Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) PARP1 ADPRT PPOL Homo sapiens (Human) TR34654_c0_g2_i1 Q920P0 DCXR_RAT 2.00E-77 GO:0042732; GO:0050038; GO:0006739; GO:0005903; GO:0005881; GO:0006006; GO:0016020; GO:0005902; GO:0016655; GO:0051289; GO:0005997 "D-xylose metabolic process; L-xylulose reductase (NADP+) activity; NADP metabolic process; brush border; cytoplasmic microtubule; glucose metabolic process; membrane; microvillus; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; protein homotetramerization; xylulose metabolic process" IPR002198; IPR002347; IPR016040; IPR020904; L-xylulose reductase (XR) (EC 1.1.1.10) (Dicarbonyl/L-xylulose reductase) Dcxr Glb Rattus norvegicus (Rat) TR34654_c0_g2_i3 Q1JP75 DCXR_BOVIN 3.00E-75 GO:0042732; GO:0050038; GO:0006739; GO:0005903; GO:0005881; GO:0006006; GO:0016020; GO:0005902; GO:0016655; GO:0051289; GO:0005997 "D-xylose metabolic process; L-xylulose reductase (NADP+) activity; NADP metabolic process; brush border; cytoplasmic microtubule; glucose metabolic process; membrane; microvillus; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; protein homotetramerization; xylulose metabolic process" IPR002198; IPR002347; IPR016040; IPR020904; L-xylulose reductase (XR) (EC 1.1.1.10) (Dicarbonyl/L-xylulose reductase) DCXR Bos taurus (Bovine) TR34654_c0_g2_i4 Q8CPI3 FABG_STAES 2.00E-35 GO:0004316; GO:0051287; GO:0050661; GO:0030497 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NAD binding; NADP binding; fatty acid elongation IPR011284; IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) (Beta-Ketoacyl-acyl carrier protein reductase) (Beta-ketoacyl-ACP reductase) fabG SE_0906 Staphylococcus epidermidis (strain ATCC 12228) TR34654_c0_g2_i6 Q16698 DECR_HUMAN 2.00E-09 GO:0008670; GO:0070402; GO:0006635; GO:0005759; GO:0005634; GO:0016651; GO:0051289 "2,4-dienoyl-CoA reductase (NADPH) activity; NADPH binding; fatty acid beta-oxidation; mitochondrial matrix; nucleus; oxidoreductase activity, acting on NAD(P)H; protein homotetramerization" IPR002347; IPR016040; "2,4-dienoyl-CoA reductase, mitochondrial (EC 1.3.1.34) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH])" DECR1 DECR Homo sapiens (Human) TR34654_c0_g2_i7 Q91XV4 DCXR_MESAU 1.00E-54 GO:0042732; GO:0050038; GO:0001669; GO:0005881; GO:0006006; GO:0016020; GO:0051289; GO:0005997 D-xylose metabolic process; L-xylulose reductase (NADP+) activity; acrosomal vesicle; cytoplasmic microtubule; glucose metabolic process; membrane; protein homotetramerization; xylulose metabolic process IPR002198; IPR002347; IPR016040; IPR020904; L-xylulose reductase (XR) (EC 1.1.1.10) (Dicarbonyl/L-xylulose reductase) (Sperm antigen P26h) DCXR Mesocricetus auratus (Golden hamster) TR34655_c1_g1_i1 Q54SU1 KBP_DICDI 2.00E-17 GO:0005856; GO:0006839; GO:0005739 cytoskeleton; mitochondrial transport; mitochondrion IPR022083; Protein KBP homolog kbp DDB_G0282223 Dictyostelium discoideum (Slime mold) TR34655_c1_g1_i2 Q5ZIL9 KBP_CHICK 3.00E-127 GO:0030154; GO:0005856; GO:0006839; GO:0005739; GO:0007399 cell differentiation; cytoskeleton; mitochondrial transport; mitochondrion; nervous system development IPR022083; IPR011990; KIF1-binding protein homolog kbp RCJMB04_25c4 Gallus gallus (Chicken) TR34655_c2_g1_i1 P36609 NCS2_CAEEL 4.00E-78 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Neuronal calcium sensor 2 (NCS-2) ncs-2 F10G8.5 Caenorhabditis elegans TR34655_c2_g1_i5 P42325 NCAH_DROME 2.00E-60 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Neurocalcin homolog (DrosNCa) Nca CG7641 Drosophila melanogaster (Fruit fly) TR34657_c0_g1_i2 Q923Z3 MTO1_MOUSE 1.00E-76 GO:0050660; GO:0070899; GO:0005739; GO:0055114 flavin adenine dinucleotide binding; mitochondrial tRNA wobble uridine modification; mitochondrion; oxidation-reduction process IPR013027; IPR004416; IPR026904; IPR002218; IPR020595; "Protein MTO1 homolog, mitochondrial" Mto1 Mus musculus (Mouse) TR34657_c0_g1_i4 A5VT19 MNMG_BRUO2 2.00E-61 GO:0005737; GO:0050660; GO:0002098 cytoplasm; flavin adenine dinucleotide binding; tRNA wobble uridine modification IPR004416; IPR026904; IPR002218; IPR020595; tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG (Glucose-inhibited division protein A) mnmG gidA BOV_1981 Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512) TR34659_c1_g1_i2 Q80ZA4 PKHL1_MOUSE 8.00E-114 GO:0016021 integral to membrane IPR008972; IPR019316; IPR013783; IPR014756; IPR002909; IPR011658; IPR006626; IPR011050; Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86) Pkhd1l1 Mus musculus (Mouse) TR3466_c0_g1_i1 Q5XJK1 SCOCB_DANRE 2.00E-32 GO:0000139; GO:0005829 Golgi membrane; cytosol IPR019357; Short coiled-coil protein B scocb zgc:101848 Danio rerio (Zebrafish) (Brachydanio rerio) TR34661_c0_g1_i1 P21195 PDIA1_RABIT 0 GO:0045454; GO:0005788; GO:0006662; GO:0042470; GO:0005886; GO:0003756; GO:0015035; GO:0006457 cell redox homeostasis; endoplasmic reticulum lumen; glycerol ether metabolic process; melanosome; plasma membrane; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; protein folding IPR005788; IPR005792; IPR005746; IPR012336; IPR017937; IPR013766; Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) P4HB PDIA1 Oryctolagus cuniculus (Rabbit) TR34662_c0_g1_i1 Q5QD05 TAA8C_MOUSE 1.00E-06 GO:0016021; GO:0005886; GO:0001594 integral to membrane; plasma membrane; trace-amine receptor activity IPR000276; IPR017452; IPR009132; Trace amine-associated receptor 8c (TaR-8c) (Trace amine receptor 8c) (mTaar8c) Taar8c Mus musculus (Mouse) TR34662_c0_g1_i2 Q92847 GHSR_HUMAN 5.00E-06 GO:0008154; GO:0008343; GO:0009986; GO:0032869; GO:0046697; GO:0001616; GO:0030252; GO:0016520; GO:0009755; GO:0016021; GO:0045121; GO:0050728; GO:0046676; GO:0032691; GO:0045409; GO:0042536; GO:0043005; GO:0017046; GO:0005886; GO:0032100; GO:0045923; GO:0043568; GO:0040018; GO:0043134; GO:0051963; GO:0032094 actin polymerization or depolymerization; adult feeding behavior; cell surface; cellular response to insulin stimulus; decidualization; growth hormone secretagogue receptor activity; growth hormone secretion; growth hormone-releasing hormone receptor activity; hormone-mediated signaling pathway; integral to membrane; membrane raft; negative regulation of inflammatory response; negative regulation of insulin secretion; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 biosynthetic process; negative regulation of tumor necrosis factor biosynthetic process; neuron projection; peptide hormone binding; plasma membrane; positive regulation of appetite; positive regulation of fatty acid metabolic process; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; regulation of hindgut contraction; regulation of synapse assembly; response to food IPR003905; IPR000276; IPR017452; Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) GHSR Homo sapiens (Human) TR34663_c5_g5_i6 Q9VCA2 ORCT_DROME 5.00E-56 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR34663_c5_g5_i8 Q66J54 S226A_XENLA 7.00E-59 GO:0016021; GO:0015075; GO:0005886 integral to membrane; ion transmembrane transporter activity; plasma membrane IPR020846; IPR016196; IPR004749; IPR005828; IPR005829; Solute carrier family 22 member 6-A (Organic cation transporter 1-A) (Renal organic anion transporter 1-A) (ROAT1-A) slc22a6-a oat1-a Xenopus laevis (African clawed frog) TR34665_c0_g1_i1 Q8TWG0 NPD_METKA 3.00E-15 GO:0070403; GO:0017136; GO:0005737; GO:0036047; GO:0036049; GO:0036054; GO:0036055; GO:0006355; GO:0006351; GO:0008270 "NAD+ binding; NAD-dependent histone deacetylase activity; cytoplasm; peptidyl-lysine demalonylation; peptidyl-lysine desuccinylation; protein-malonyllysine demalonylase activity; protein-succinyllysine desuccinylase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003000; IPR026591; IPR027546; IPR026590; NAD-dependent protein deacylase (EC 3.5.1.-) (Regulatory protein SIR2 homolog) cobB MK1075 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) TR34665_c0_g1_i2 Q9FE17 SIR1_ARATH 3.00E-31 GO:0070403; GO:0016787; GO:0046872; GO:0005634 NAD+ binding; hydrolase activity; metal ion binding; nucleus IPR003000; IPR026590; NAD-dependent protein deacetylase SRT1 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) SRT1 At5g55760 MDF20.20 Arabidopsis thaliana (Mouse-ear cress) TR34665_c0_g2_i4 Q5L014 NPD1_GEOKA 2.00E-08 GO:0070403; GO:0005737; GO:0016787; GO:0046872 NAD+ binding; cytoplasm; hydrolase activity; metal ion binding IPR003000; IPR026591; IPR026590; NAD-dependent protein deacetylase 1 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 1) cobB1 GK1437 Geobacillus kaustophilus (strain HTA426) TR34665_c0_g3_i2 Q9FE17 SIR1_ARATH 2.00E-19 GO:0070403; GO:0016787; GO:0046872; GO:0005634 NAD+ binding; hydrolase activity; metal ion binding; nucleus IPR003000; IPR026590; NAD-dependent protein deacetylase SRT1 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) SRT1 At5g55760 MDF20.20 Arabidopsis thaliana (Mouse-ear cress) TR34665_c0_g3_i3 Q8N6T7 SIR6_HUMAN 2.00E-19 GO:0003956; GO:0003950; GO:0070403; GO:0046969; GO:0005724; GO:0005654; GO:0006471; GO:0010569; GO:0008270 P01106; Q04206 NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity (H3-K9 specific); nuclear telomeric heterochromatin; nucleoplasm; protein ADP-ribosylation; regulation of double-strand break repair via homologous recombination; zinc ion binding IPR003000; IPR026590; NAD-dependent protein deacetylase sirtuin-6 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 6) (SIR2-like protein 6) SIRT6 SIR2L6 Homo sapiens (Human) TR34665_c0_g3_i4 Q9VH08 SIR6_DROME 2.00E-15 GO:0070403; GO:0008340; GO:0016787; GO:0046872 NAD+ binding; determination of adult lifespan; hydrolase activity; metal ion binding IPR003000; IPR026590; NAD-dependent protein deacetylase Sirt6 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 6) (SIR2-like protein 6) Sirt6 CG6284 Drosophila melanogaster (Fruit fly) TR34669_c0_g1_i2 Q96C45 ULK4_HUMAN 1.00E-95 GO:0005524; GO:0060271; GO:0003351; GO:0004674; GO:0021591 ATP binding; cilium morphogenesis; epithelial cilium movement; protein serine/threonine kinase activity; ventricular system development IPR011989; IPR016024; IPR011009; IPR000719; Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4) ULK4 Homo sapiens (Human) TR34669_c0_g2_i1 Q3V129 ULK4_MOUSE 5.00E-59 GO:0005524; GO:0060271; GO:0003351; GO:0004674; GO:0021591 ATP binding; cilium morphogenesis; epithelial cilium movement; protein serine/threonine kinase activity; ventricular system development IPR011989; IPR016024; IPR011009; IPR000719; Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4) Ulk4 Mus musculus (Mouse) TR34671_c0_g1_i1 Q9NRA2 S17A5_HUMAN 6.00E-83 GO:0006865; GO:0030054; GO:0005887; GO:0005765; GO:0015136; GO:0015739; GO:0005351; GO:0030672 amino acid transport; cell junction; integral to plasma membrane; lysosomal membrane; sialic acid transmembrane transporter activity; sialic acid transport; sugar:hydrogen symporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) TR34672_c3_g1_i1 Q95SX7 RTBS_DROME 4.00E-25 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR34672_c4_g1_i1 Q99757 THIOM_HUMAN 1.00E-18 GO:0045454; GO:0031669; GO:0030425; GO:0006662; GO:0005739; GO:0043025; GO:0005730; GO:0015035; GO:0048678; GO:0042493; GO:0009749; GO:0009725; GO:0001666; GO:0007584; GO:0014070; GO:0006979 cell redox homeostasis; cellular response to nutrient levels; dendrite; glycerol ether metabolic process; mitochondrion; neuronal cell body; nucleolus; protein disulfide oxidoreductase activity; response to axon injury; response to drug; response to glucose stimulus; response to hormone stimulus; response to hypoxia; response to nutrient; response to organic cyclic compound; response to oxidative stress IPR005746; IPR012336; IPR017937; IPR013766; "Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)" TXN2 TRX2 Homo sapiens (Human) TR34673_c0_g2_i1 Q47S78 RNC_THEFY 3.00E-08 GO:0005737; GO:0006397; GO:0046872; GO:0090305; GO:0019843; GO:0016075; GO:0006364; GO:0004525; GO:0008033 cytoplasm; mRNA processing; metal ion binding; nucleic acid phosphodiester bond hydrolysis; rRNA binding; rRNA catabolic process; rRNA processing; ribonuclease III activity; tRNA processing IPR014720; IPR011907; IPR000999; Ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III) rnc Tfu_0651 Thermobifida fusca (strain YX) TR34673_c0_g2_i2 Q9ZBQ7 RNC_STRCO 4.00E-08 GO:0005737; GO:0006397; GO:0046872; GO:0090305; GO:0019843; GO:0016075; GO:0006364; GO:0004525; GO:0008033 cytoplasm; mRNA processing; metal ion binding; nucleic acid phosphodiester bond hydrolysis; rRNA binding; rRNA catabolic process; rRNA processing; ribonuclease III activity; tRNA processing IPR014720; IPR011907; IPR000999; Ribonuclease 3 (EC 3.1.26.3) (Antibiotic biosynthesis protein B) (AbsB) (Ribonuclease III) (RNase III) rnc absB SCO5572 SC7A1.16 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) TR34673_c1_g1_i1 Q660G7 RNC_BORGA 6.00E-08 GO:0005737; GO:0006397; GO:0046872; GO:0090305; GO:0019843; GO:0016075; GO:0006364; GO:0004525; GO:0008033 cytoplasm; mRNA processing; metal ion binding; nucleic acid phosphodiester bond hydrolysis; rRNA binding; rRNA catabolic process; rRNA processing; ribonuclease III activity; tRNA processing IPR014720; IPR011907; IPR000999; Ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III) rnc BG0727 Borrelia garinii (strain PBi) TR34673_c1_g1_i2 P51400 RED1_RAT 8.00E-44 GO:0006396; GO:0006382; GO:0003726; GO:0003725; GO:0016556; GO:0006397; GO:0046872; GO:0030336; GO:0008285; GO:0044387; GO:0005730; GO:0005654; GO:0045070; GO:0051726 RNA processing; adenosine to inosine editing; double-stranded RNA adenosine deaminase activity; double-stranded RNA binding; mRNA modification; mRNA processing; metal ion binding; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of protein kinase activity by regulation of protein phosphorylation; nucleolus; nucleoplasm; positive regulation of viral genome replication; regulation of cell cycle IPR002466; IPR014720; Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) Adarb1 Red1 Rattus norvegicus (Rat) TR34673_c1_g1_i5 P55265 DSRAD_HUMAN 6.00E-61 GO:0003677; GO:0003723; GO:0006382; GO:0005737; GO:0051607; GO:0003726; GO:0010467; GO:0031047; GO:0016556; GO:0006397; GO:0046872; GO:0043066; GO:0044387; GO:0005730; GO:0005654; GO:0005634; GO:0045070; GO:0006611; GO:0006606; GO:0035455; GO:0009615; GO:0044530; GO:0060337 Q99IB8; Q9UPY3; Q15633 DNA binding; RNA binding; adenosine to inosine editing; cytoplasm; defense response to virus; double-stranded RNA adenosine deaminase activity; gene expression; gene silencing by RNA; mRNA modification; mRNA processing; metal ion binding; negative regulation of apoptotic process; negative regulation of protein kinase activity by regulation of protein phosphorylation; nucleolus; nucleoplasm; nucleus; positive regulation of viral genome replication; protein export from nucleus; protein import into nucleus; response to interferon-alpha; response to virus; supraspliceosomal complex; type I interferon-mediated signaling pathway IPR002466; IPR014720; IPR000607; IPR011991; Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) ADAR ADAR1 DSRAD G1P1 IFI4 Homo sapiens (Human) TR34673_c1_g4_i2 P78563 RED1_HUMAN 2.00E-07 GO:0003723; GO:0006396; GO:0004000; GO:0006382; GO:0016553; GO:0051607; GO:0003726; GO:0003725; GO:0010467; GO:0045087; GO:0003729; GO:0016556; GO:0006397; GO:0046872; GO:0030336; GO:0008285; GO:0044387; GO:0005730; GO:0005654; GO:0005634; GO:0045070; GO:0051726 Q13526; O00308 RNA binding; RNA processing; adenosine deaminase activity; adenosine to inosine editing; base conversion or substitution editing; defense response to virus; double-stranded RNA adenosine deaminase activity; double-stranded RNA binding; gene expression; innate immune response; mRNA binding; mRNA modification; mRNA processing; metal ion binding; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of protein kinase activity by regulation of protein phosphorylation; nucleolus; nucleoplasm; nucleus; positive regulation of viral genome replication; regulation of cell cycle IPR002466; IPR008996; IPR014720; Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) ADARB1 ADAR2 DRADA2 RED1 Homo sapiens (Human) TR34674_c1_g1_i3 Q5BL73 DDA1_XENTR 3.00E-25 IPR018276; DET1- and DDB1-associated protein 1 dda1 TNeu111h01.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34675_c3_g1_i1 Q66HV9 LIG1B_DANRE 2.00E-08 GO:0016021; GO:0005886 Q6NW92 integral to membrane; plasma membrane IPR007110; IPR013783; IPR013098; IPR003598; IPR003591; IPR000372; Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1-B lingo1b lingo1 si:ch211-116a8.1 zgc:92338 Danio rerio (Zebrafish) (Brachydanio rerio) TR34675_c4_g1_i1 P08953 TOLL_DROME 2.00E-06 GO:0033565; GO:0008063; GO:0019732; GO:0007155; GO:0019955; GO:0050830; GO:0005769; GO:0009897; GO:0007507; GO:0035172; GO:0030097; GO:0045087; GO:0016021; GO:0006963; GO:0006967; GO:0045610; GO:0007416; GO:0016201; GO:0004888; GO:0007352 Itself; Q7K105 ESCRT-0 complex; Toll signaling pathway; antifungal humoral response; cell adhesion; cytokine binding; defense response to Gram-positive bacterium; early endosome; external side of plasma membrane; heart development; hemocyte proliferation; hemopoiesis; innate immune response; integral to membrane; positive regulation of antibacterial peptide biosynthetic process; positive regulation of antifungal peptide biosynthetic process; regulation of hemocyte differentiation; synapse assembly; synaptic target inhibition; transmembrane signaling receptor activity; zygotic specification of dorsal/ventral axis IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) TR34675_c5_g2_i1 Q6PJG9 LRFN4_HUMAN 8.00E-10 GO:0016021 integral to membrane IPR000483; IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR003591; IPR000372; Leucine-rich repeat and fibronectin type-III domain-containing protein 4 LRFN4 SALM3 Homo sapiens (Human) TR34675_c5_g2_i2 Q0ZUL9 TLR6_DASNO 4.00E-13 GO:0002755; GO:0042088; GO:0035355; GO:0071726; GO:0042496; GO:0042498; GO:0006954; GO:0045087; GO:0016021; GO:0030670; GO:0043123; GO:0043507; GO:0045410; GO:0050707; GO:0034150; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; T-helper 1 type immune response; Toll-like receptor 2-Toll-like receptor 6 protein complex; cellular response to diacyl bacterial lipopeptide; detection of diacyl bacterial lipopeptide; diacyl lipopeptide binding; inflammatory response; innate immune response; integral to membrane; phagocytic vesicle membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JUN kinase activity; positive regulation of interleukin-6 biosynthetic process; regulation of cytokine secretion; toll-like receptor 6 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR000157; IPR027187; IPR017241; Toll-like receptor 6 (CD antigen CD286) TLR6 Dasypus novemcinctus (Nine-banded armadillo) TR34675_c5_g2_i3 Q0ZUL9 TLR6_DASNO 3.00E-13 GO:0002755; GO:0042088; GO:0035355; GO:0071726; GO:0042496; GO:0042498; GO:0006954; GO:0045087; GO:0016021; GO:0030670; GO:0043123; GO:0043507; GO:0045410; GO:0050707; GO:0034150; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; T-helper 1 type immune response; Toll-like receptor 2-Toll-like receptor 6 protein complex; cellular response to diacyl bacterial lipopeptide; detection of diacyl bacterial lipopeptide; diacyl lipopeptide binding; inflammatory response; innate immune response; integral to membrane; phagocytic vesicle membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JUN kinase activity; positive regulation of interleukin-6 biosynthetic process; regulation of cytokine secretion; toll-like receptor 6 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR000157; IPR027187; IPR017241; Toll-like receptor 6 (CD antigen CD286) TLR6 Dasypus novemcinctus (Nine-banded armadillo) TR34675_c6_g1_i1 Q3T1I2 C1QT6_RAT 3.00E-14 GO:0005581; GO:0005615; GO:0070208 collagen; extracellular space; protein heterotrimerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 6 C1qtnf6 Rattus norvegicus (Rat) TR34675_c6_g1_i2 Q9D8U4 C1QT2_MOUSE 3.00E-08 GO:0000187; GO:0005581; GO:0005615; GO:0042802; GO:0046321; GO:0046326; GO:0045725; GO:0070208; GO:0051260; GO:0005102 activation of MAPK activity; collagen; extracellular space; identical protein binding; positive regulation of fatty acid oxidation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; protein heterotrimerization; protein homooligomerization; receptor binding IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 2 (mCTRP2) C1qtnf2 Crtp2 Mus musculus (Mouse) TR34676_c0_g2_i1 Q290P4 RM52_DROPS 1.00E-16 GO:0005762; GO:0003735; GO:0006412 mitochondrial large ribosomal subunit; structural constituent of ribosome; translation "39S ribosomal protein L52, mitochondrial (L52mt) (MRP-L52)" mRpL52 GA13944 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR34676_c0_g3_i2 Q9UBU9 NXF1_HUMAN 1.00E-150 GO:0005829; GO:0010467; GO:0003729; GO:0006406; GO:0019048; GO:0042405; GO:0005643; GO:0016607; GO:0005487; GO:0005654; GO:0000166; GO:0016973 P22575; O00571; Q08211; P37198; Q9UKK6; Q07955; P84103; Q16629; Q9Y2W1 cytosol; gene expression; mRNA binding; mRNA export from nucleus; modulation by virus of host morphology or physiology; nuclear inclusion body; nuclear pore; nuclear speck; nucleocytoplasmic transporter activity; nucleoplasm; nucleotide binding; poly(A)+ mRNA export from nucleus IPR001611; IPR002075; IPR018222; IPR012677; IPR005637; IPR015245; IPR003603; IPR009060; Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) NXF1 TAP Homo sapiens (Human) TR34678_c0_g1_i1 Q8BIY1 GPTC3_MOUSE 2.00E-68 GO:0003676 nucleic acid binding IPR000467; G patch domain-containing protein 3 Gpatch3 Gpatc3 Mus musculus (Mouse) TR34678_c0_g1_i2 Q9UTK6 YKR3_SCHPO 4.00E-06 GO:0003677; GO:0003723; GO:0005737; GO:0045292; GO:0044732; GO:0006355; GO:0005681; GO:0000390 "DNA binding; RNA binding; cytoplasm; mRNA cis splicing, via spliceosome; mitotic spindle pole body; regulation of transcription, DNA-dependent; spliceosomal complex; spliceosomal complex disassembly" IPR000467; IPR022783; G-patch domain-containing protein C1486.03 SPAC1486.03c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR34679_c0_g1_i1 P08708 RS17_HUMAN 2.00E-68 GO:0006614; GO:0022627; GO:0034101; GO:0000184; GO:0006364; GO:0000028; GO:0003735; GO:0006414; GO:0006413; GO:0006415; GO:0019083 "SRP-dependent cotranslational protein targeting to membrane; cytosolic small ribosomal subunit; erythrocyte homeostasis; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; rRNA processing; ribosomal small subunit assembly; structural constituent of ribosome; translational elongation; translational initiation; translational termination; viral transcription" IPR001210; IPR018273; 40S ribosomal protein S17 RPS17 Homo sapiens (Human) TR3468_c0_g1_i1 P12270 TPR_HUMAN 1.00E-06 GO:0005524; GO:0000189; GO:0006404; GO:0005975; GO:0051301; GO:0035457; GO:0003682; GO:0019221; GO:0005868; GO:0070840; GO:0019898; GO:0015758; GO:0031072; GO:0000776; GO:0003729; GO:0031990; GO:0051019; GO:0007067; GO:0007077; GO:0072686; GO:0007094; GO:0046832; GO:0000122; GO:0045947; GO:0042405; GO:0031965; GO:0034399; GO:0044615; GO:0006999; GO:0005487; GO:0005654; GO:0031453; GO:0090267; GO:0046827; GO:0042307; GO:0042803; GO:0010827; GO:0010965; GO:1901673; GO:0070849; GO:0004828; GO:0006434; GO:0044281; GO:0055085; GO:0015631; GO:0016032 ATP binding; MAPK import into nucleus; RNA import into nucleus; carbohydrate metabolic process; cell division; cellular response to interferon-alpha; chromatin binding; cytokine-mediated signaling pathway; cytoplasmic dynein complex; dynein complex binding; extrinsic to membrane; glucose transport; heat shock protein binding; kinetochore; mRNA binding; mRNA export from nucleus in response to heat stress; mitogen-activated protein kinase binding; mitosis; mitotic nuclear envelope disassembly; mitotic spindle; mitotic spindle assembly checkpoint; negative regulation of RNA export from nucleus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of translational initiation; nuclear inclusion body; nuclear membrane; nuclear periphery; nuclear pore nuclear basket; nuclear pore organization; nucleocytoplasmic transporter activity; nucleoplasm; positive regulation of heterochromatin assembly; positive regulation of mitotic cell cycle spindle assembly checkpoint; positive regulation of protein export from nucleus; positive regulation of protein import into nucleus; protein homodimerization activity; regulation of glucose transport; regulation of mitotic sister chromatid separation; regulation of spindle assembly involved in mitosis; response to epidermal growth factor stimulus; serine-tRNA ligase activity; seryl-tRNA aminoacylation; small molecule metabolic process; transmembrane transport; tubulin binding; viral process IPR015866; IPR012929; Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) TPR Homo sapiens (Human) TR34680_c0_g1_i2 Q4T2X8 NIP7_TETNG 3.00E-107 GO:0003723; GO:0005730; GO:0042255 RNA binding; nucleolus; ribosome assembly IPR002478; IPR015947; IPR005155; IPR016686; 60S ribosome subunit biogenesis protein NIP7 homolog nip7 GSTENG00008117001 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) TR34680_c2_g1_i1 Q8TBZ9 CG062_HUMAN 3.00E-31 Uncharacterized protein C7orf62 C7orf62 Homo sapiens (Human) TR34681_c0_g1_i10 Q5IS41 NCAN_PANTR 1.00E-17 GO:0005509; GO:0030246; GO:0007155; GO:0005576; GO:0005540 calcium ion binding; carbohydrate binding; cell adhesion; extracellular region; hyaluronic acid binding IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Neurocan core protein (Chondroitin sulfate proteoglycan 3) NCAN CSPG3 Pan troglodytes (Chimpanzee) TR34681_c0_g1_i2 Q0II24 C1QT9_BOVIN 3.00E-16 GO:0005581 collagen IPR001073; IPR008160; IPR008983; Complement C1q and tumor necrosis factor-related protein 9 C1QTNF9 Bos taurus (Bovine) TR34681_c0_g1_i3 Q5UPS7 COLL4_MIMIV 2.00E-23 GO:0005581; GO:0019012 collagen; virion IPR008160; Collagen-like protein 4 MIMI_R240 Acanthamoeba polyphaga mimivirus (APMV) TR34681_c0_g1_i4 P35247 SFTPD_HUMAN 1.00E-24 GO:0030246; GO:0005581; GO:0030139; GO:0005576; GO:0005615; GO:0045087; GO:0048286; GO:0005764; GO:0048246; GO:0042130; GO:0045085; GO:0050766; GO:0072593; GO:0006898; GO:0007585; GO:0043129 carbohydrate binding; collagen; endocytic vesicle; extracellular region; extracellular space; innate immune response; lung alveolus development; lysosome; macrophage chemotaxis; negative regulation of T cell proliferation; negative regulation of interleukin-2 biosynthetic process; positive regulation of phagocytosis; reactive oxygen species metabolic process; receptor-mediated endocytosis; respiratory gaseous exchange; surfactant homeostasis IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; IPR015097; Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (Collectin-7) (Lung surfactant protein D) SFTPD COLEC7 PSPD SFTP4 Homo sapiens (Human) TR34681_c0_g1_i5 Q9BXJ2 C1QT7_HUMAN 3.00E-06 GO:0005581 collagen IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 7 C1QTNF7 CTRP7 Homo sapiens (Human) TR34681_c0_g1_i6 P50404 SFTPD_MOUSE 2.00E-22 GO:0030246; GO:0005581; GO:0005737; GO:0005615; GO:0048286; GO:0007585; GO:0043129 carbohydrate binding; collagen; cytoplasm; extracellular space; lung alveolus development; respiratory gaseous exchange; surfactant homeostasis IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; IPR015097; Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (Lung surfactant protein D) Sftpd Sftp4 Mus musculus (Mouse) TR34681_c0_g1_i8 P35248 SFTPD_RAT 6.00E-24 GO:0005581; GO:0031410; GO:0005615; GO:0042802; GO:0001530; GO:0048286; GO:0048029; GO:0005771; GO:0042130; GO:0032703; GO:0050765; GO:0008228; GO:0050766; GO:0050828; GO:0007585; GO:0051384; GO:0070848; GO:0055093; GO:0005791; GO:0043129 collagen; cytoplasmic vesicle; extracellular space; identical protein binding; lipopolysaccharide binding; lung alveolus development; monosaccharide binding; multivesicular body; negative regulation of T cell proliferation; negative regulation of interleukin-2 production; negative regulation of phagocytosis; opsonization; positive regulation of phagocytosis; regulation of liquid surface tension; respiratory gaseous exchange; response to glucocorticoid stimulus; response to growth factor stimulus; response to hyperoxia; rough endoplasmic reticulum; surfactant homeostasis IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; IPR015097; Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (CP4) (Lung surfactant protein D) Sftpd Sftp4 Rattus norvegicus (Rat) TR34682_c2_g1_i2 P71824 Y769_MYCTU 2.00E-23 GO:0016491; GO:0005886 oxidoreductase activity; plasma membrane IPR002198; IPR002347; IPR016040; Uncharacterized oxidoreductase Rv0769/MT0793 (EC 1.-.-.-) Rv0769 MT0793 Mycobacterium tuberculosis TR34682_c2_g1_i3 Q7Z4W1 DCXR_HUMAN 5.00E-69 GO:0042732; GO:0050038; GO:0006739; GO:0005903; GO:0005881; GO:0006006; GO:0016020; GO:0005902; GO:0016655; GO:0051289; GO:0005997 "D-xylose metabolic process; L-xylulose reductase (NADP+) activity; NADP metabolic process; brush border; cytoplasmic microtubule; glucose metabolic process; membrane; microvillus; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; protein homotetramerization; xylulose metabolic process" IPR002198; IPR002347; IPR016040; IPR020904; L-xylulose reductase (XR) (EC 1.1.1.10) (Carbonyl reductase II) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Sperm surface protein P34H) DCXR Homo sapiens (Human) TR34682_c2_g1_i6 P42556 PTR1_LEITA 3.00E-06 GO:0047040; GO:0031427; GO:0006729 pteridine reductase activity; response to methotrexate; tetrahydrobiopterin biosynthetic process IPR002198; IPR002347; IPR016040; IPR014058; IPR020904; Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from biopterin: step 1/1. Pteridine reductase 1 (EC 1.5.1.33) (H region methotrexate resistance protein) PTR1 LTDH Leishmania tarentolae (Sauroleishmania tarentolae) TR34682_c2_g1_i7 Q9RA05 LIMC_RHOER 4.00E-24 GO:0046251; GO:0016616 "limonene catabolic process; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" IPR023985; IPR002198; IPR002347; IPR016040; IPR020904; Terpene metabolism; limonene degradation. "(-)-trans-carveol dehydrogenase (EC 1.1.1.n4) ((4R,6S)-carveol dehydrogenase) (CDH) (Carveol dehydrogenase)" limC Rhodococcus erythropolis (Arthrobacter picolinophilus) TR34682_c2_g1_i8 A1L1W4 RD10A_DANRE 5.00E-06 GO:0052650; GO:0005789; GO:0016021 NADP-retinol dehydrogenase activity; endoplasmic reticulum membrane; integral to membrane IPR002198; IPR002347; IPR016040; IPR020904; Cofactor metabolism; retinol metabolism. Retinol dehydrogenase 10-A (EC 1.1.1.300) rdh10a zgc:158459 Danio rerio (Zebrafish) (Brachydanio rerio) TR34683_c0_g1_i1 Q5M9I5 QCR6_RAT 5.00E-13 GO:0006122; GO:0005750; GO:0032403; GO:0051291; GO:0008121 "mitochondrial electron transport, ubiquinol to cytochrome c; mitochondrial respiratory chain complex III; protein complex binding; protein heterooligomerization; ubiquinol-cytochrome-c reductase activity" IPR003422; IPR023184; "Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein)" Uqcrh Rattus norvegicus (Rat) TR34683_c0_g1_i3 Q5M9I5 QCR6_RAT 4.00E-13 GO:0006122; GO:0005750; GO:0032403; GO:0051291; GO:0008121 "mitochondrial electron transport, ubiquinol to cytochrome c; mitochondrial respiratory chain complex III; protein complex binding; protein heterooligomerization; ubiquinol-cytochrome-c reductase activity" IPR003422; IPR023184; "Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein)" Uqcrh Rattus norvegicus (Rat) TR34685_c1_g1_i1 Q2TBW2 COQ7_BOVIN 5.00E-64 GO:0001306; GO:0034599; GO:0008340; GO:0001701; GO:0046872; GO:0042775; GO:0005743; GO:0070584; GO:0001841; GO:0022008; GO:0005634; GO:0006744 age-dependent response to oxidative stress; cellular response to oxidative stress; determination of adult lifespan; in utero embryonic development; metal ion binding; mitochondrial ATP synthesis coupled electron transport; mitochondrial inner membrane; mitochondrion morphogenesis; neural tube formation; neurogenesis; nucleus; ubiquinone biosynthetic process IPR009078; IPR012347; IPR011566; Cofactor biosynthesis; ubiquinone biosynthesis. Ubiquinone biosynthesis protein COQ7 homolog (Coenzyme Q biosynthesis protein 7 homolog) (Timing protein clk-1 homolog) COQ7 Bos taurus (Bovine) TR34685_c1_g1_i3 Q47IC7 COQ7_DECAR 1.00E-07 GO:0046872; GO:0004497; GO:0005886; GO:0019538; GO:0006744 metal ion binding; monooxygenase activity; plasma membrane; protein metabolic process; ubiquinone biosynthetic process IPR009078; IPR012347; IPR011566; IPR023782; Cofactor biosynthesis; ubiquinone biosynthesis. "2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase (EC 1.14.13.-) (5-demethoxyubiquinone hydroxylase) (DMQ hydroxylase)" coq7 Daro_0647 Dechloromonas aromatica (strain RCB) TR34688_c1_g1_i1 Q5ZL74 VAMP7_CHICK 9.00E-10 GO:0006888; GO:0005794; GO:0043001; GO:0031201; GO:0045177; GO:0017156; GO:0030054; GO:0005789; GO:0008333; GO:0043308; GO:0016021; GO:0031902; GO:0005765; GO:0043005; GO:0043312; GO:0048471; GO:0045335; GO:0030670; GO:0006911; GO:1900483; GO:0045202; GO:0030658; GO:0006906 "ER to Golgi vesicle-mediated transport; Golgi apparatus; Golgi to plasma membrane protein transport; SNARE complex; apical part of cell; calcium ion-dependent exocytosis; cell junction; endoplasmic reticulum membrane; endosome to lysosome transport; eosinophil degranulation; integral to membrane; late endosome membrane; lysosomal membrane; neuron projection; neutrophil degranulation; perinuclear region of cytoplasm; phagocytic vesicle; phagocytic vesicle membrane; phagocytosis, engulfment; regulation of protein targeting to vacuolar membrane; synapse; transport vesicle membrane; vesicle fusion" IPR011012; IPR010908; IPR001388; Vesicle-associated membrane protein 7 (Synaptobrevin-like protein 1) VAMP7 SYBL1 RCJMB04_7f19 Gallus gallus (Chicken) TR34689_c1_g1_i1 Q92609 TBCD5_HUMAN 2.00E-76 GO:0005097; GO:0032851; GO:0030904 P54253 Rab GTPase activator activity; positive regulation of Rab GTPase activity; retromer complex IPR000195; TBC1 domain family member 5 TBC1D5 KIAA0210 Homo sapiens (Human) TR34689_c3_g1_i1 Q54TA5 TBC5B_DICDI 5.00E-30 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; TBC1 domain family member 5 homolog B tbc1d5B DDB_G0281891 Dictyostelium discoideum (Slime mold) TR34689_c3_g2_i2 Q92609 TBCD5_HUMAN 1.00E-61 GO:0005097; GO:0032851; GO:0030904 P54253 Rab GTPase activator activity; positive regulation of Rab GTPase activity; retromer complex IPR000195; TBC1 domain family member 5 TBC1D5 KIAA0210 Homo sapiens (Human) TR34691_c2_g1_i1 P06353 H33_HORVU 9.00E-44 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR000164; Histone H3.3 (Fragment) Hordeum vulgare (Barley) TR34691_c3_g1_i1 P84239 H3_URECA 3.00E-62 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR000164; Histone H3 Urechis caupo (Innkeeper worm) (Spoonworm) TR34691_c3_g1_i2 P69127 H32_TETTR 3.00E-17 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR000164; Histone H3.2 (Fragment) Tetrahymena tropicalis TR34691_c6_g1_i1 P80249 MT14_MYTED 6.00E-20 GO:0046872 metal ion binding IPR001008; IPR003019; Metallothionein 10-IV (MT-10-IV) Mytilus edulis (Blue mussel) TR34691_c6_g1_i9 P80248 MT13_MYTED 1.00E-28 GO:0046872 metal ion binding IPR001008; IPR003019; Metallothionein 10-III (MT-10-III) Mytilus edulis (Blue mussel) TR34692_c0_g1_i1 O46640 ST3A1_RABIT 7.00E-47 GO:0047685; GO:0005737 amine sulfotransferase activity; cytoplasm IPR027417; IPR000863; Amine sulfotransferase (EC 2.8.2.3) (AST-RB1) (Sulfotransferase 3A1) (ST3A1) SULT3A1 ST3A1 Oryctolagus cuniculus (Rabbit) TR34694_c0_g1_i1 O15770 GSHR_PLAF7 3.00E-104 GO:0045454; GO:0005737; GO:0050660; GO:0004362 cell redox homeostasis; cytoplasm; flavin adenine dinucleotide binding; glutathione-disulfide reductase activity IPR016156; IPR013027; IPR004099; IPR023753; IPR012999; IPR001327; Glutathione reductase (GR) (GRase) (EC 1.8.1.7) GR3 PF14_0192 Plasmodium falciparum (isolate 3D7) TR34694_c0_g1_i2 A2TIL1 GSHR_CALJA 0 GO:0050661; GO:0045454; GO:0050660; GO:0006749; GO:0004362; GO:0005739 NADP binding; cell redox homeostasis; flavin adenine dinucleotide binding; glutathione metabolic process; glutathione-disulfide reductase activity; mitochondrion IPR016156; IPR013027; IPR006322; IPR004099; IPR023753; IPR012999; IPR001327; "Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7)" GSR Callithrix jacchus (White-tufted-ear marmoset) TR34698_c1_g1_i1 P23098 DYHC_TRIGR 0 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein beta chain, ciliary" Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla) TR34698_c2_g1_i1 Q8IID4 DYHC2_PLAF7 2.00E-36 GO:0005524; GO:0006200; GO:0016887; GO:0005737; GO:0030286; GO:0005874; GO:0005875; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cytoplasm; dynein complex; microtubule; microtubule associated complex; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR017868; IPR013783; IPR014756; IPR015915; IPR027417; Dynein heavy chain-like protein PF11_0240 PF11_0240 Plasmodium falciparum (isolate 3D7) TR34698_c2_g1_i4 P23098 DYHC_TRIGR 0 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein beta chain, ciliary" Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla) TR34699_c0_g2_i2 O16025 AOSL_PLEHO 2.00E-33 GO:0047677; GO:0019369; GO:0004096; GO:0005737; GO:0020037; GO:0047987; GO:0005506; GO:0016020; GO:0031408 arachidonate 8(R)-lipoxygenase activity; arachidonic acid metabolic process; catalase activity; cytoplasm; heme binding; hydroperoxide dehydratase activity; iron ion binding; membrane; oxylipin biosynthetic process IPR020835; IPR011614; IPR008976; IPR000907; IPR013819; IPR020834; IPR020833; IPR001885; IPR001024; Lipid metabolism; arachidonate metabolism. Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (EC 4.2.1.92) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)] Plexaura homomalla (Black sea rod) TR34699_c0_g4_i1 O75342 LX12B_HUMAN 8.00E-35 GO:0004052; GO:0019369; GO:0046513; GO:0005829; GO:0061436; GO:0051122; GO:0005506; GO:1990136; GO:0043651; GO:0019372; GO:0043410; GO:0010628; GO:0070257; GO:0006497 Q9BYJ1 arachidonate 12-lipoxygenase activity; arachidonic acid metabolic process; ceramide biosynthetic process; cytosol; establishment of skin barrier; hepoxilin biosynthetic process; iron ion binding; linoleate 9S-lipoxygenase activity; linoleic acid metabolic process; lipoxygenase pathway; positive regulation of MAPK cascade; positive regulation of gene expression; positive regulation of mucus secretion; protein lipidation IPR008976; IPR000907; IPR013819; IPR020834; IPR020833; IPR001885; IPR001024; Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis. Lipid metabolism; sphingolipid metabolism. "Arachidonate 12-lipoxygenase, 12R-type (12R-LOX) (12R-lipoxygenase) (EC 1.13.11.-) (Epidermis-type lipoxygenase 12)" ALOX12B Homo sapiens (Human) TR34700_c0_g2_i2 Q5VVB8 TM244_HUMAN 4.00E-18 GO:0016021 integral to membrane Transmembrane protein 244 TMEM244 C6orf191 Homo sapiens (Human) TR34701_c0_g1_i1 Q54Q40 D1039_DICDI 5.00E-24 GO:0046872; GO:0008237; GO:0006508 metal ion binding; metallopeptidase activity; proteolysis IPR000555; IPR015063; Probable ubiquitin thioesterase DG1039 (EC 3.4.19.-) (Developmental gene 1039 protein) DG1039 DDB_G0284037 Dictyostelium discoideum (Slime mold) TR34701_c0_g1_i2 Q9P371 SST2_SCHPO 2.00E-24 GO:0032153; GO:0006897; GO:0005768; GO:0046872; GO:0008237; GO:0016579; GO:0043328; GO:0030133; GO:0004221; GO:0004843 cell division site; endocytosis; endosome; metal ion binding; metallopeptidase activity; protein deubiquitination; protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; transport vesicle; ubiquitin thiolesterase activity; ubiquitin-specific protease activity IPR000555; IPR015063; AMSH-like protease sst2 (EC 3.4.19.-) (Suppressor of ste12 deletion protein 2) sst2 SPAC19B12.10 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR34701_c0_g2_i2 O95630 STABP_HUMAN 3.00E-32 GO:0007259; GO:0032154; GO:0005737; GO:0005769; GO:0046872; GO:0008237; GO:0000281; GO:0046580; GO:0043066; GO:0014067; GO:0005634; GO:0005886; GO:0008284; GO:0016579; GO:0006508; GO:0004843 Q9HD42; Q7LBR1; Q9Y3E7; Q9NZZ3; P62993; Q9Y3C5; O43541-2; Q92783; O75886 JAK-STAT cascade; cleavage furrow; cytoplasm; early endosome; metal ion binding; metallopeptidase activity; mitotic cytokinesis; negative regulation of Ras protein signal transduction; negative regulation of apoptotic process; negative regulation of phosphatidylinositol 3-kinase cascade; nucleus; plasma membrane; positive regulation of cell proliferation; protein deubiquitination; proteolysis; ubiquitin-specific protease activity IPR000555; IPR015063; STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase) STAMBP AMSH Homo sapiens (Human) TR34701_c0_g3_i1 O95630 STABP_HUMAN 7.00E-33 GO:0007259; GO:0032154; GO:0005737; GO:0005769; GO:0046872; GO:0008237; GO:0000281; GO:0046580; GO:0043066; GO:0014067; GO:0005634; GO:0005886; GO:0008284; GO:0016579; GO:0006508; GO:0004843 Q9HD42; Q7LBR1; Q9Y3E7; Q9NZZ3; P62993; Q9Y3C5; O43541-2; Q92783; O75886 JAK-STAT cascade; cleavage furrow; cytoplasm; early endosome; metal ion binding; metallopeptidase activity; mitotic cytokinesis; negative regulation of Ras protein signal transduction; negative regulation of apoptotic process; negative regulation of phosphatidylinositol 3-kinase cascade; nucleus; plasma membrane; positive regulation of cell proliferation; protein deubiquitination; proteolysis; ubiquitin-specific protease activity IPR000555; IPR015063; STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase) STAMBP AMSH Homo sapiens (Human) TR34702_c0_g1_i1 P06276 CHLE_HUMAN 3.00E-53 GO:0003990; GO:0001540; GO:0004091; GO:0044267; GO:0019695; GO:0050783; GO:0005788; GO:0019899; GO:0005615; GO:0016020; GO:0005641; GO:0007271 Itself "acetylcholinesterase activity; beta-amyloid binding; carboxylesterase activity; cellular protein metabolic process; choline metabolic process; cocaine metabolic process; endoplasmic reticulum lumen; enzyme binding; extracellular space; membrane; nuclear envelope lumen; synaptic transmission, cholinergic" IPR014788; IPR002018; IPR019826; IPR019819; IPR000997; Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase) BCHE CHE1 Homo sapiens (Human) TR34702_c0_g1_i2 P23795 ACES_BOVIN 2.00E-37 GO:0003990; GO:0031225; GO:0030424; GO:0001540; GO:0004091; GO:0030054; GO:0009986; GO:0019695; GO:0030425; GO:0005788; GO:0005615; GO:0031594; GO:0042135; GO:0045211; GO:0042734; GO:0050770; GO:0048814; GO:0007416; GO:0007271 "acetylcholinesterase activity; anchored to membrane; axon; beta-amyloid binding; carboxylesterase activity; cell junction; cell surface; choline metabolic process; dendrite; endoplasmic reticulum lumen; extracellular space; neuromuscular junction; neurotransmitter catabolic process; postsynaptic membrane; presynaptic membrane; regulation of axonogenesis; regulation of dendrite morphogenesis; synapse assembly; synaptic transmission, cholinergic" IPR014788; IPR002018; IPR019826; IPR019819; IPR000997; Acetylcholinesterase (AChE) (EC 3.1.1.7) ACHE Bos taurus (Bovine) TR34704_c2_g1_i1 Q54NZ7 ALRB_DICDI 3.00E-61 GO:0004032 alditol:NADP+ 1-oxidoreductase activity IPR001395; IPR018170; IPR020471; IPR023210; Aldose reductase B (ARB) (EC 1.1.1.21) (Aldehyde reductase B) alrB DDB_G0285053 Dictyostelium discoideum (Slime mold) TR34705_c0_g1_i1 Q8RXH2 NUP85_ARATH 2.00E-09 GO:0051028; GO:0005635; GO:0031965; GO:0005643; GO:0015031 mRNA transport; nuclear envelope; nuclear membrane; nuclear pore; protein transport IPR011502; Nuclear pore complex protein Nup85 (Nucleoporin Nup85) NUP85 At4g32910 F26P21.30 Arabidopsis thaliana (Mouse-ear cress) TR34705_c0_g4_i1 Q6DBY0 NUP85_DANRE 1.00E-98 GO:0051028; GO:0031965; GO:0031080; GO:0015031 mRNA transport; nuclear membrane; nuclear pore outer ring; protein transport IPR011502; Nuclear pore complex protein Nup85 (85 kDa nucleoporin) (Nucleoporin Nup85) (Pericentrin-1) nup85 pcnt1 zgc:100943 Danio rerio (Zebrafish) (Brachydanio rerio) TR34705_c0_g4_i2 Q6DBY0 NUP85_DANRE 2.00E-13 GO:0051028; GO:0031965; GO:0031080; GO:0015031 mRNA transport; nuclear membrane; nuclear pore outer ring; protein transport IPR011502; Nuclear pore complex protein Nup85 (85 kDa nucleoporin) (Nucleoporin Nup85) (Pericentrin-1) nup85 pcnt1 zgc:100943 Danio rerio (Zebrafish) (Brachydanio rerio) TR34706_c5_g2_i2 Q7T3T9 ZAR1_TAKRU 7.00E-16 GO:0005737; GO:0007275 cytoplasm; multicellular organismal development IPR026775; IPR027377; Zygote arrest protein 1 (Oocyte-specific maternal effect factor) zar1 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR34708_c7_g1_i1 O43301 HS12A_HUMAN 5.00E-63 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR34708_c7_g2_i1 Q96MM6 HS12B_HUMAN 7.00E-32 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR34708_c9_g1_i1 Q6V0K7 OIT3_RAT 2.00E-09 GO:0005635 nuclear envelope IPR000742; IPR001507; Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein) Oit3 Lzp Rattus norvegicus (Rat) TR34711_c0_g1_i3 Q802F3 SEP15_DANRE 9.00E-40 GO:0005788; GO:0008430 endoplasmic reticulum lumen; selenium binding IPR014912; IPR012336; 15 kDa selenoprotein sep15 cb29 zgc:86882 Danio rerio (Zebrafish) (Brachydanio rerio) TR34712_c3_g1_i2 Q5TM64 CF136_MACMU 1.00E-08 IPR018790; Uncharacterized protein C6orf136 homolog Macaca mulatta (Rhesus macaque) TR34712_c3_g2_i1 Q5SQH8 CF136_HUMAN 3.00E-07 GO:0005739 mitochondrion IPR018790; Uncharacterized protein C6orf136 C6orf136 Homo sapiens (Human) TR34713_c0_g4_i1 Q8IWF7 U2D2L_HUMAN 9.00E-23 GO:0016881 acid-amino acid ligase activity IPR000608; IPR016135; Putative ubiquitin-conjugating enzyme E2 D2-like protein (Ubiquitin carrier protein D2-like) (Ubiquitin-conjugating enzyme E2D N-terminal-like) (Ubiquitin-protein ligase D2-like) UBE2DNL UBE2D2L Homo sapiens (Human) TR34713_c0_g5_i1 P62840 UB2D2_XENLA 1.00E-49 GO:0005524; GO:0004842 ATP binding; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 D2 (EC 6.3.2.19) (Ubiquitin carrier protein 4) (xUBC4) (Ubiquitin carrier protein D2) (Ubiquitin-protein ligase D2) ube2d2 ubc4 ube2d3.1 Xenopus laevis (African clawed frog) TR34713_c0_g5_i3 Q4V908 UBE2S_DANRE 3.00E-25 GO:0005524; GO:0051488; GO:0005680; GO:0031145; GO:0051301; GO:0010458; GO:0010994; GO:0070979; GO:0004842 ATP binding; activation of anaphase-promoting complex activity; anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; exit from mitosis; free ubiquitin chain polymerization; protein K11-linked ubiquitination; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 S (EC 6.3.2.19) (Ubiquitin carrier protein S) (Ubiquitin-protein ligase S) ube2s zgc:114060 Danio rerio (Zebrafish) (Brachydanio rerio) TR34713_c0_g6_i2 Q4R4I1 UBE2N_MACFA 1.00E-29 GO:0005524; GO:0006281; GO:0035370; GO:0070534; GO:0000151; GO:0004842 ATP binding; DNA repair; UBC13-UEV1A complex; protein K63-linked ubiquitination; ubiquitin ligase complex; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 N (EC 6.3.2.19) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N) UBE2N QtrA-13863 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR34713_c0_g6_i4 Q7M767 UB2V2_RAT 4.00E-07 GO:0000729; GO:0031372; GO:0016881; GO:0043524; GO:0005634; GO:0045739; GO:0010976; GO:0032436; GO:0051965 DNA double-strand break processing; UBC13-MMS2 complex; acid-amino acid ligase activity; negative regulation of neuron apoptotic process; nucleus; positive regulation of DNA repair; positive regulation of neuron projection development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of synapse assembly IPR000608; IPR016135; Ubiquitin-conjugating enzyme E2 variant 2 (Ubiquitin-conjugating enzyme variant MMS2) Ube2v2 Mms2 Uev2 Rattus norvegicus (Rat) TR34719_c4_g2_i1 P08487 PLCG1_BOVIN 5.00E-12 GO:0008180; GO:0005509; GO:0071364; GO:0001701; GO:0035556; GO:0030027; GO:0004435; GO:0005543; GO:0009395; GO:0010634; GO:0001726; GO:0004871 P22681; O43561-2; Q13094; P09619; P48025; P15498 COP9 signalosome; calcium ion binding; cellular response to epidermal growth factor stimulus; in utero embryonic development; intracellular signal transduction; lamellipodium; phosphatidylinositol phospholipase C activity; phospholipid binding; phospholipid catabolic process; positive regulation of epithelial cell migration; ruffle; signal transducer activity IPR000008; IPR018247; IPR002048; IPR011993; IPR001192; IPR016279; IPR017946; IPR001849; IPR015359; IPR000909; IPR001711; IPR000980; IPR001452; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)" PLCG1 Bos taurus (Bovine) TR34719_c4_g2_i3 P08487 PLCG1_BOVIN 2.00E-12 GO:0008180; GO:0005509; GO:0071364; GO:0001701; GO:0035556; GO:0030027; GO:0004435; GO:0005543; GO:0009395; GO:0010634; GO:0001726; GO:0004871 P22681; O43561-2; Q13094; P09619; P48025; P15498 COP9 signalosome; calcium ion binding; cellular response to epidermal growth factor stimulus; in utero embryonic development; intracellular signal transduction; lamellipodium; phosphatidylinositol phospholipase C activity; phospholipid binding; phospholipid catabolic process; positive regulation of epithelial cell migration; ruffle; signal transducer activity IPR000008; IPR018247; IPR002048; IPR011993; IPR001192; IPR016279; IPR017946; IPR001849; IPR015359; IPR000909; IPR001711; IPR000980; IPR001452; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)" PLCG1 Bos taurus (Bovine) TR34719_c5_g1_i1 Q46891 YGBM_ECOLI 3.00E-57 GO:0008903 P0A6F5 hydroxypyruvate isomerase activity IPR026040; IPR013022; Putative hydroxypyruvate isomerase YgbM (EC 5.3.1.22) (Glyoxylate-induced protein YgbM) ygbM b2739 JW2709 Escherichia coli (strain K12) TR34719_c5_g1_i3 Q8R1F5 HYI_MOUSE 1.00E-76 GO:0008903 hydroxypyruvate isomerase activity IPR026040; IPR013022; Putative hydroxypyruvate isomerase (EC 5.3.1.22) Hyi Mus musculus (Mouse) TR3472_c0_g1_i1 Q9ESN4 C1QL3_MOUSE 8.00E-13 GO:0005581; GO:0005576; GO:0050807 collagen; extracellular region; regulation of synapse organization IPR001073; IPR008160; IPR008983; Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13) (CTRP13) (Gliacolin) C1ql3 C1ql Ctrp13 Mus musculus (Mouse) TR3472_c0_g2_i1 Q9Y6C2 EMIL1_HUMAN 4.00E-06 GO:0007155; GO:0005581; GO:0030023; GO:0030198; GO:0070062; GO:0010811 cell adhesion; collagen; extracellular matrix constituent conferring elasticity; extracellular matrix organization; extracellular vesicular exosome; positive regulation of cell-substrate adhesion IPR001073; IPR008160; IPR011489; IPR008983; EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1) EMILIN1 EMI Homo sapiens (Human) TR34723_c0_g1_i1 O15975 GNAQ_MIZYE 0 GO:0007186; GO:0005525; GO:0003924; GO:0046872; GO:0004871 G-protein coupled receptor signaling pathway; GTP binding; GTPase activity; metal ion binding; signal transducer activity IPR000654; IPR001019; IPR011025; IPR027417; Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q) SCGQA Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) TR34726_c1_g1_i1 O60140 YNS9_SCHPO 4.00E-41 GO:0005737; GO:0008270 cytoplasm; zinc ion binding IPR008913; Uncharacterized protein C18H10.09 SPBC18H10.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR34727_c0_g1_i1 Q6UXB8 PI16_HUMAN 5.00E-15 GO:0005576; GO:0016021; GO:0030414 extracellular region; integral to membrane; peptidase inhibitor activity IPR001283; IPR018244; IPR014044; Peptidase inhibitor 16 (PI-16) (Cysteine-rich secretory protein 9) (CRISP-9) (PSP94-binding protein) PI16 CRISP9 PSPBP PSEC0164 UNQ289/PRO328 Homo sapiens (Human) TR34728_c0_g1_i2 P07898 PGCA_CHICK 6.00E-08 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Gallus gallus (Chicken) TR34728_c0_g1_i4 P86854 PLCL_MYTGA 3.00E-10 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR34728_c0_g1_i5 P10716 CLC4F_RAT 6.00E-09 GO:0030246; GO:0006897; GO:0016021; GO:0004872 carbohydrate binding; endocytosis; integral to membrane; receptor activity IPR001304; IPR016186; IPR018378; IPR016187; C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13) (Kupffer cell receptor) Clec4f Clecsf13 Kclr Rattus norvegicus (Rat) TR34729_c2_g1_i2 O95257 GA45G_HUMAN 4.00E-10 GO:0006281; GO:0000186; GO:0000185; GO:0006915; GO:0030154; GO:0007275; GO:0006469; GO:0005634; GO:0051726 Q8TAE8; Q92993; Q9P2H0; Q9Y3C7; Q9BVJ6 DNA repair; activation of MAPKK activity; activation of MAPKKK activity; apoptotic process; cell differentiation; multicellular organismal development; negative regulation of protein kinase activity; nucleus; regulation of cell cycle IPR024824; IPR004038; Growth arrest and DNA damage-inducible protein GADD45 gamma (Cytokine-responsive protein CR6) (DNA damage-inducible transcript 2 protein) (DDIT-2) GADD45G CR6 DDIT2 Homo sapiens (Human) TR34729_c2_g1_i3 Q60GI5 GA45A_FELCA 2.00E-09 GO:0007050; GO:0071479; GO:0071260; GO:0007098; GO:0001047; GO:0006469; GO:0005634; GO:2000379; GO:0042770 cell cycle arrest; cellular response to ionizing radiation; cellular response to mechanical stimulus; centrosome cycle; core promoter binding; negative regulation of protein kinase activity; nucleus; positive regulation of reactive oxygen species metabolic process; signal transduction in response to DNA damage IPR024824; IPR004038; Growth arrest and DNA damage-inducible protein GADD45 alpha GADD45A Felis catus (Cat) (Felis silvestris catus) TR34730_c2_g1_i1 A0JPA1 RHDF2_XENTR 3.00E-72 GO:0005789; GO:0016021; GO:0050709; GO:0015031; GO:0006508; GO:0004252 endoplasmic reticulum membrane; integral to membrane; negative regulation of protein secretion; protein transport; proteolysis; serine-type endopeptidase activity IPR002610; IPR022764; IPR022241; Inactive rhomboid protein 2 (iRhom2) (Rhomboid family member 2) rhbdf2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34731_c0_g1_i3 Q61510 TRI25_MOUSE 2.00E-06 GO:0030054; GO:0005737; GO:0051607; GO:0045087; GO:0005634; GO:0004842; GO:0008270 cell junction; cytoplasm; defense response to virus; innate immune response; nucleus; ubiquitin-protein ligase activity; zinc ion binding IPR001870; IPR003879; IPR008985; IPR006574; IPR018355; IPR003877; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.19) (EC 6.3.2.n3) (Estrogen-responsive finger protein) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) Trim25 Efp Zfp147 Znf147 Mus musculus (Mouse) TR34732_c5_g2_i1 Q6P2H3 CEP85_HUMAN 1.00E-25 GO:0005813; GO:0005737; GO:0005730; GO:0000922 centrosome; cytoplasm; nucleolus; spindle pole Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21) CEP85 CCDC21 Homo sapiens (Human) TR34733_c0_g1_i1 P02723 ADT_NEUCR 4.00E-132 GO:0016021; GO:0005743; GO:0055085; GO:0005215 integral to membrane; mitochondrial inner membrane; transmembrane transport; transporter activity IPR002113; IPR002067; IPR018108; IPR023395; "ADP,ATP carrier protein (ADP/ATP translocase) (Adenine nucleotide translocator) (ANT)" acp B22K18.180 NCU09477 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR34734_c0_g1_i1 Q0PMG2 MDGA1_MOUSE 2.00E-16 GO:0046658; GO:0021799; GO:0001764 anchored to plasma membrane; cerebral cortex radially oriented cell migration; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 Mdga1 Mus musculus (Mouse) TR34734_c0_g1_i3 Q5VYJ5 CJ112_HUMAN 3.00E-12 GO:0016021 integral to membrane IPR008985; IPR023415; IPR002172; IPR000998; MAM and LDL-receptor class A domain-containing protein C10orf112 C10orf112 Homo sapiens (Human) TR34735_c0_g1_i1 P50429 ARSB_MOUSE 1.00E-123 GO:0005794; GO:0003943; GO:0004065; GO:0006914; GO:0007417; GO:0005764; GO:0046872; GO:0005739; GO:0043627; GO:0051597; GO:0007584; GO:0009268; GO:0005791 Golgi apparatus; N-acetylgalactosamine-4-sulfatase activity; arylsulfatase activity; autophagy; central nervous system development; lysosome; metal ion binding; mitochondrion; response to estrogen stimulus; response to methylmercury; response to nutrient; response to pH; rough endoplasmic reticulum IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb As1 As1-s Mus musculus (Mouse) TR34736_c0_g2_i1 P52590 NU107_RAT 0 GO:0000777; GO:0006406; GO:0031965; GO:0034399; GO:0051292; GO:0031080; GO:0005487; GO:0015031; GO:0017056 condensed chromosome kinetochore; mRNA export from nucleus; nuclear membrane; nuclear periphery; nuclear pore complex assembly; nuclear pore outer ring; nucleocytoplasmic transporter activity; protein transport; structural constituent of nuclear pore IPR007252; Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107) (p105) Nup107 Rattus norvegicus (Rat) TR34737_c2_g1_i1 Q14790 CASP8_HUMAN 4.00E-16 GO:0031265; GO:0030690; GO:0035666; GO:0006919; GO:0001525; GO:0044297; GO:0006921; GO:0071260; GO:0005813; GO:0097153; GO:0005829; GO:0031264; GO:0097191; GO:0007507; GO:0045087; GO:0097193; GO:0030225; GO:0045121; GO:0005741; GO:0019048; GO:0043124; GO:0001841; GO:0043005; GO:0070423; GO:0005634; GO:0043123; GO:0045651; GO:1900740; GO:0045862; GO:0051291; GO:0051603; GO:2001239; GO:0046677; GO:0032025; GO:0009409; GO:0032355; GO:0045471; GO:0032496; GO:0034612; GO:0097342; GO:0034138; GO:0034142 P51572; Q92851; Q9UKL3; O15519-1; Q13618; Q13158; P25445; P48023; Q13418; Q9UDY8; O60936; P29350; Q13546; O00220 CD95 death-inducing signaling complex; Noc1p-Noc2p complex; TRIF-dependent toll-like receptor signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cell body; cellular component disassembly involved in execution phase of apoptosis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; cytosol; death-inducing signaling complex; extrinsic apoptotic signaling pathway; heart development; innate immune response; intrinsic apoptotic signaling pathway; macrophage differentiation; membrane raft; mitochondrial outer membrane; modulation by virus of host morphology or physiology; negative regulation of I-kappaB kinase/NF-kappaB cascade; neural tube formation; neuron projection; nucleotide-binding oligomerization domain containing signaling pathway; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macrophage differentiation; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of proteolysis; protein heterooligomerization; proteolysis involved in cellular protein catabolic process; regulation of extrinsic apoptotic signaling pathway in absence of ligand; response to antibiotic; response to cobalt ion; response to cold; response to estradiol stimulus; response to ethanol; response to lipopolysaccharide; response to tumor necrosis factor; ripoptosome; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] CASP8 MCH5 Homo sapiens (Human) TR34737_c2_g1_i4 O89110 CASP8_MOUSE 5.00E-14 GO:0030690; GO:0006919; GO:0001525; GO:0071260; GO:0005813; GO:0097153; GO:0031264; GO:0008625; GO:0007507; GO:0097284; GO:0030225; GO:0005739; GO:0043124; GO:0060546; GO:0001841; GO:0043123; GO:2001238; GO:0045651; GO:0045862; GO:0051603; GO:0070243; GO:0034612 P10275; P19091; P25446; Q9D8Y7 Noc1p-Noc2p complex; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; death-inducing signaling complex; extrinsic apoptotic signaling pathway via death domain receptors; heart development; hepatocyte apoptotic process; macrophage differentiation; mitochondrion; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of necroptosis; neural tube formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of macrophage differentiation; positive regulation of proteolysis; proteolysis involved in cellular protein catabolic process; regulation of thymocyte apoptotic process; response to tumor necrosis factor IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] Casp8 Mus musculus (Mouse) TR34738_c1_g2_i1 Q8CBY1 SMAG1_MOUSE 4.00E-102 GO:0030054; GO:0005737; GO:0030425; GO:0045727; GO:0045202; GO:0030371 cell junction; cytoplasm; dendrite; positive regulation of translation; synapse; translation repressor activity IPR001660; IPR013761; IPR021129; IPR015327; Protein Smaug homolog 1 (Smaug 1) (mSmaug 1) (Sterile alpha motif domain-containing protein 4A) Samd4a Samd4 Smaug1 Mus musculus (Mouse) TR34739_c0_g1_i2 Q6FSK8 DPB2_CANGA 2.00E-36 GO:0003677; GO:0006260; GO:0003887; GO:0005634 DNA binding; DNA replication; DNA-directed DNA polymerase activity; nucleus IPR007185; DNA polymerase epsilon subunit B (EC 2.7.7.7) (DNA polymerase II subunit 2) DPB2 CAGL0G09801g Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) TR34739_c0_g1_i3 A7YWS7 DPOE2_BOVIN 0 GO:0003677; GO:0006261; GO:0003887; GO:0008622 DNA binding; DNA-dependent DNA replication; DNA-directed DNA polymerase activity; epsilon DNA polymerase complex IPR007185; IPR016266; IPR024639; DNA polymerase epsilon subunit 2 (EC 2.7.7.7) (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B) POLE2 Bos taurus (Bovine) TR34740_c2_g2_i1 P06276 CHLE_HUMAN 7.00E-83 GO:0003990; GO:0001540; GO:0004091; GO:0044267; GO:0019695; GO:0050783; GO:0005788; GO:0019899; GO:0005615; GO:0016020; GO:0005641; GO:0007271 Itself "acetylcholinesterase activity; beta-amyloid binding; carboxylesterase activity; cellular protein metabolic process; choline metabolic process; cocaine metabolic process; endoplasmic reticulum lumen; enzyme binding; extracellular space; membrane; nuclear envelope lumen; synaptic transmission, cholinergic" IPR014788; IPR002018; IPR019826; IPR019819; IPR000997; Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase) BCHE CHE1 Homo sapiens (Human) TR34740_c2_g2_i3 Q86GC8 ACES_CULPI 5.00E-98 GO:0003990; GO:0004091; GO:0030054; GO:0005576; GO:0042135; GO:0005886; GO:0045202 acetylcholinesterase activity; carboxylesterase activity; cell junction; extracellular region; neurotransmitter catabolic process; plasma membrane; synapse IPR002018; IPR019826; IPR019819; IPR000997; Acetylcholinesterase (AChE) (EC 3.1.1.7) ACHE1 Culex pipiens (House mosquito) TR34740_c2_g3_i1 Q8WMH2 NLGN3_MACMU 6.00E-11 GO:0007155; GO:0030054; GO:0009986; GO:0005887; GO:0042043; GO:0004872; GO:0045202; GO:0007416 cell adhesion; cell junction; cell surface; integral to plasma membrane; neurexin family protein binding; receptor activity; synapse; synapse assembly IPR002018; IPR000460; Neuroligin-3 (Gliotactin homolog) (Fragment) NLGN3 Macaca mulatta (Rhesus macaque) TR34741_c0_g1_i2 P82977 ICIW_WHEAT 5.00E-13 GO:0005576; GO:0009611; GO:0004867 extracellular region; response to wounding; serine-type endopeptidase inhibitor activity IPR000864; Subtilisin-chymotrypsin inhibitor WSCI Triticum aestivum (Wheat) TR34741_c0_g1_i5 P86971 ITI_FAGTA 1.00E-06 GO:0050832; GO:0031640; GO:0009611; GO:0004867 defense response to fungus; killing of cells of other organism; response to wounding; serine-type endopeptidase inhibitor activity IPR000864; Trypsin inhibitor (FtTI) Fagopyrum tataricum (Tartarian buckwheat) (Polygonum tataricum) TR34741_c0_g1_i7 P16064 ICI1_PHAAN 7.00E-13 GO:0009611; GO:0004867 response to wounding; serine-type endopeptidase inhibitor activity IPR000864; Subtilisin inhibitor 1 (ASI-I) (Subtilisin inhibitor I) [Cleaved into: Subtilisin inhibitor 2 (ASI-II) (Subtilisin inhibitor II)] Phaseolus angularis (Azuki bean) (Vigna angularis) TR34742_c0_g1_i1 P12261 EF1G_ARTSA 2.00E-144 GO:0005853; GO:0003746 eukaryotic translation elongation factor 1 complex; translation elongation factor activity IPR010987; IPR004045; IPR004046; IPR012336; IPR001662; Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) Artemia salina (Brine shrimp) TR34742_c0_g1_i2 P54412 EF1G_CAEEL 7.00E-90 GO:0005853; GO:0003746 eukaryotic translation elongation factor 1 complex; translation elongation factor activity IPR010987; IPR004046; IPR012336; IPR001662; Probable elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) F17C11.9 Caenorhabditis elegans TR34747_c0_g1_i2 Q8N488 RYBP_HUMAN 4.00E-16 GO:0003677; GO:0006915; GO:0005737; GO:0035518; GO:0007275; GO:0000122; GO:0005654; GO:0003714; GO:0006351; GO:0008270 Q00987; Q06587; P04637; P0CG48 "DNA binding; apoptotic process; cytoplasm; histone H2A monoubiquitination; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription corepressor activity; transcription, DNA-dependent; zinc ion binding" IPR001876; RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) RYBP DEDAF YEAF1 Homo sapiens (Human) TR34751_c0_g1_i1 Q8VEH8 ERLEC_MOUSE 2.00E-101 GO:0030433; GO:0005788; GO:0001948 ER-associated protein catabolic process; endoplasmic reticulum lumen; glycoprotein binding IPR009011; IPR012913; Endoplasmic reticulum lectin 1 (ER lectin) (Erlectin) Erlec1 Mus musculus (Mouse) TR34752_c2_g1_i1 Q4KM79 DUS11_RAT 1.00E-45 GO:0003723; GO:0005634; GO:0035335; GO:0004725; GO:0008138 RNA binding; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR000387; IPR016130; RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Dual specificity protein phosphatase 11) (Phosphatase that interacts with RNA/RNP complex 1) Dusp11 Pir1 Rattus norvegicus (Rat) TR34753_c2_g1_i1 Q8TB24 RIN3_HUMAN 2.00E-10 GO:0005096; GO:0017137; GO:0017112; GO:0016023; GO:0031410; GO:0005769; GO:0006897; GO:0043547; GO:0007165 P16333; P19174 GTPase activator activity; Rab GTPase binding; Rab guanyl-nucleotide exchange factor activity; cytoplasmic membrane-bounded vesicle; cytoplasmic vesicle; early endosome; endocytosis; positive regulation of GTPase activity; signal transduction IPR000159; IPR000980; IPR003123; IPR013995; Ras and Rab interactor 3 (Ras interaction/interference protein 3) RIN3 Homo sapiens (Human) TR34753_c3_g1_i1 Q8MQW8 SPRI_DROME 2.00E-50 GO:0005096; GO:0007298; GO:0005938; GO:0030139; GO:0006897; GO:0005085; GO:0007275; GO:0043547; GO:0007165 GTPase activator activity; border follicle cell migration; cell cortex; endocytic vesicle; endocytosis; guanyl-nucleotide exchange factor activity; multicellular organismal development; positive regulation of GTPase activity; signal transduction IPR000159; IPR000980; IPR003123; IPR013995; Protein sprint (SH2 poly-proline-containing Ras-interactor protein) spri CG34414 Drosophila melanogaster (Fruit fly) TR34754_c4_g1_i1 Q922M7 ASHWN_MOUSE 8.00E-08 GO:0048598; GO:0072669 embryonic morphogenesis; tRNA-splicing ligase complex IPR024887; Ashwin Mus musculus (Mouse) TR34756_c0_g1_i1 Q8IVV2 LOXH1_HUMAN 1.00E-10 GO:0005262; GO:0050982; GO:0016020; GO:0007605; GO:0032420 calcium channel activity; detection of mechanical stimulus; membrane; sensory perception of sound; stereocilium IPR008976; IPR001024; Lipoxygenase homology domain-containing protein 1 LOXHD1 Homo sapiens (Human) TR34756_c0_g1_i2 O16025 AOSL_PLEHO 2.00E-65 GO:0047677; GO:0019369; GO:0004096; GO:0005737; GO:0020037; GO:0047987; GO:0005506; GO:0016020; GO:0031408 arachidonate 8(R)-lipoxygenase activity; arachidonic acid metabolic process; catalase activity; cytoplasm; heme binding; hydroperoxide dehydratase activity; iron ion binding; membrane; oxylipin biosynthetic process IPR020835; IPR011614; IPR008976; IPR000907; IPR013819; IPR020834; IPR020833; IPR001885; IPR001024; Lipid metabolism; arachidonate metabolism. Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (EC 4.2.1.92) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)] Plexaura homomalla (Black sea rod) TR34757_c2_g2_i1 Q5SDR3 BMI1_CHICK 8.00E-64 GO:0031519; GO:0016568; GO:0030890; GO:0033092; GO:0051443; GO:0006355; GO:0006351; GO:0000151; GO:0008270 "PcG protein complex; chromatin modification; positive regulation of B cell proliferation; positive regulation of immature T cell proliferation in thymus; positive regulation of ubiquitin-protein ligase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin ligase complex; zinc ion binding" IPR018957; IPR001841; IPR013083; IPR017907; Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) BMI1 PCGF4 Gallus gallus (Chicken) TR34757_c2_g2_i2 Q6NRG0 RNF8B_XENLA 3.00E-06 GO:0051301; GO:0003682; GO:0000781; GO:0006303; GO:0070535; GO:0033523; GO:0042393; GO:0043486; GO:0045190; GO:0045900; GO:0005634; GO:0045739; GO:0070936; GO:0042803; GO:0010212; GO:0035861; GO:0007286; GO:0000151; GO:0006511; GO:0004842; GO:0008270 "cell division; chromatin binding; chromosome, telomeric region; double-strand break repair via nonhomologous end joining; histone H2A K63-linked ubiquitination; histone H2B ubiquitination; histone binding; histone exchange; isotype switching; negative regulation of translational elongation; nucleus; positive regulation of DNA repair; protein K48-linked ubiquitination; protein homodimerization activity; response to ionizing radiation; site of double-strand break; spermatid development; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding" IPR017335; IPR000253; IPR008984; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF8-B (EC 6.3.2.-) (RING finger protein 8-B) rnf8-b Xenopus laevis (African clawed frog) TR34758_c4_g1_i2 Q5R5R4 RUFY2_PONAB 0 GO:0046872; GO:0005634 metal ion binding; nucleus IPR004012; IPR000306; IPR017455; IPR011011; IPR013083; RUN and FYVE domain-containing protein 2 RUFY2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34758_c4_g1_i3 Q8BIJ7 RUFY1_MOUSE 0 GO:0005737; GO:0031901; GO:0006897; GO:0008289; GO:0046872; GO:0008565; GO:0030100 cytoplasm; early endosome membrane; endocytosis; lipid binding; metal ion binding; protein transporter activity; regulation of endocytosis IPR004012; IPR000306; IPR017455; IPR011011; IPR013083; RUN and FYVE domain-containing protein 1 (Rab4-interacting protein) Rufy1 Rabip4 Mus musculus (Mouse) TR34759_c0_g1_i1 Q5ZLR1 WLS_CHICK 9.00E-92 GO:0000139; GO:0016055; GO:0030659; GO:0016021; GO:0007275 Golgi membrane; Wnt receptor signaling pathway; cytoplasmic vesicle membrane; integral to membrane; multicellular organismal development IPR009551; Protein wntless homolog (Integral membrane protein GPR177) WLS GPR177 RCJMB04_5c7 Gallus gallus (Chicken) TR34760_c0_g2_i1 P81383 OXLA_OPHHA 2.00E-06 GO:0001716; GO:0006915; GO:0019835; GO:0042742; GO:0005576; GO:0050660; GO:0044179; GO:0031640; GO:0046983 L-amino-acid oxidase activity; apoptotic process; cytolysis; defense response to bacterium; extracellular region; flavin adenine dinucleotide binding; hemolysis in other organism; killing of cells of other organism; protein dimerization activity IPR002937; IPR001613; L-amino-acid oxidase (LAAO) (LAO) (Oh-LAAO) (EC 1.4.3.2) Ophiophagus hannah (King cobra) (Naja hannah) TR34760_c1_g1_i1 P49109 FMO5_CAVPO 7.00E-51 GO:0004499; GO:0050661; GO:0005789; GO:0050660; GO:0016021 "N,N-dimethylaniline monooxygenase activity; NADP binding; endoplasmic reticulum membrane; flavin adenine dinucleotide binding; integral to membrane" IPR012143; IPR000960; IPR020946; IPR002257; IPR016040; Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5) FMO5 Cavia porcellus (Guinea pig) TR34763_c1_g2_i1 Q7SZ59 RASLC_DANRE 1.00E-30 GO:0005525; GO:0003924; GO:0016020; GO:0007264 GTP binding; GTPase activity; membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; Ras-like protein family member 12 (RAS-like protein Ris) RASL12 zgc:63633 Danio rerio (Zebrafish) (Brachydanio rerio) TR34763_c1_g2_i2 P13856 RSR1_YEAST 2.00E-18 GO:0005525; GO:0003924; GO:0007120; GO:0007121; GO:0005935; GO:0005886; GO:0004871; GO:0007264 GTP binding; GTPase activity; axial cellular bud site selection; bipolar cellular bud site selection; cellular bud neck; plasma membrane; signal transducer activity; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; Ras-related protein RSR1 RSR1 BUD1 YGR152C G6658 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR34763_c1_g2_i3 Q08CX1 RASEF_XENTR 4.00E-08 GO:0005525; GO:0005509; GO:0048471; GO:0015031; GO:0007264 GTP binding; calcium ion binding; perinuclear region of cytoplasm; protein transport; small GTPase mediated signal transduction IPR011992; IPR002048; IPR027417; IPR005225; IPR001806; IPR003579; Ras and EF-hand domain-containing protein rasef Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34763_c1_g2_i4 Q6DGN0 RERGL_DANRE 1.00E-28 GO:0005525; GO:0003924; GO:0016020; GO:0007264 GTP binding; GTPase activity; membrane; small GTPase mediated signal transduction IPR027417; IPR001806; IPR020849; Ras-related and estrogen-regulated growth inhibitor-like protein (RERG/Ras-like protein) rergl zgc:92849 Danio rerio (Zebrafish) (Brachydanio rerio) TR34763_c1_g2_i5 Q7SZ59 RASLC_DANRE 3.00E-31 GO:0005525; GO:0003924; GO:0016020; GO:0007264 GTP binding; GTPase activity; membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; Ras-like protein family member 12 (RAS-like protein Ris) RASL12 zgc:63633 Danio rerio (Zebrafish) (Brachydanio rerio) TR34765_c0_g2_i1 Q8R151 ZNFX1_MOUSE 3.00E-07 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR34765_c3_g1_i1 Q8R151 ZNFX1_MOUSE 1.00E-29 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR34768_c2_g1_i1 Q9BWJ5 SF3B5_HUMAN 8.00E-45 GO:0005689; GO:0000398; GO:0005654 "U12-type spliceosomal complex; mRNA splicing, via spliceosome; nucleoplasm" IPR009846; IPR017089; Splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit) SF3B5 SF3B10 Homo sapiens (Human) TR34768_c2_g1_i2 Q9VHI4 SF3B5_DROME 1.00E-47 GO:0000398; GO:0007052; GO:0071011 Q9VDK2 "mRNA splicing, via spliceosome; mitotic spindle organization; precatalytic spliceosome" IPR009846; IPR017089; Probable splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit) CG11985 Drosophila melanogaster (Fruit fly) TR34768_c2_g1_i6 Q9VHI4 SF3B5_DROME 7.00E-47 GO:0000398; GO:0007052; GO:0071011 Q9VDK2 "mRNA splicing, via spliceosome; mitotic spindle organization; precatalytic spliceosome" IPR009846; IPR017089; Probable splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit) CG11985 Drosophila melanogaster (Fruit fly) TR34770_c0_g1_i1 Q802G7 SELM_DANRE 1.00E-19 IPR014912; IPR012336; Selenoprotein M (SePM) (SelM) selm sepm zgc:103431 Danio rerio (Zebrafish) (Brachydanio rerio) TR34770_c0_g1_i2 G4WAW9 SELM_ERISI 4.00E-27 GO:0005783 endoplasmic reticulum IPR014912; IPR012336; Selenoprotein M SelM Eriocheir sinensis (Chinese mitten crab) TR34773_c1_g4_i1 D3ZAT9 FAXC_RAT 6.00E-36 GO:0016021 integral to membrane IPR026928; IPR010987; IPR012336; Failed axon connections homolog Faxc Rattus norvegicus (Rat) TR34773_c1_g7_i3 F7E235 FAXC_XENTR 3.00E-36 GO:0016021 integral to membrane IPR026928; IPR010987; IPR012336; Failed axon connections homolog faxc Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34774_c1_g2_i1 P54213 CATR_DUNSA 2.00E-23 GO:0005509; GO:0051301; GO:0007067 calcium ion binding; cell division; mitosis IPR011992; IPR018247; IPR002048; Caltractin (Centrin) Dunaliella salina (Green alga) TR34774_c1_g2_i2 P54213 CATR_DUNSA 2.00E-13 GO:0005509; GO:0051301; GO:0007067 calcium ion binding; cell division; mitosis IPR011992; IPR018247; IPR002048; Caltractin (Centrin) Dunaliella salina (Green alga) TR34774_c2_g2_i3 Q5RDB5 CNIH_PONAB 1.00E-47 GO:0000139; GO:0005789; GO:0016021; GO:0035556; GO:0016192 Golgi membrane; endoplasmic reticulum membrane; integral to membrane; intracellular signal transduction; vesicle-mediated transport IPR003377; Protein cornichon homolog 1 (CNIH-1) (Cornichon family AMPA receptor auxiliary protein 1) (Protein cornichon homolog) CNIH1 CNIH Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34775_c0_g1_i1 P51810 GP143_HUMAN 1.00E-15 GO:0005794; GO:0072544; GO:0035643; GO:0016324; GO:0035584; GO:0035240; GO:0006726; GO:0016021; GO:0005765; GO:0033162; GO:0032438; GO:0032402; GO:0048015; GO:0050848; GO:0072545; GO:0007601 Q16655 Golgi apparatus; L-DOPA binding; L-DOPA receptor activity; apical plasma membrane; calcium-mediated signaling using intracellular calcium source; dopamine binding; eye pigment biosynthetic process; integral to membrane; lysosomal membrane; melanosome membrane; melanosome organization; melanosome transport; phosphatidylinositol-mediated signaling; regulation of calcium-mediated signaling; tyrosine binding; visual perception IPR001414; G-protein coupled receptor 143 (Ocular albinism type 1 protein) GPR143 OA1 Homo sapiens (Human) TR34777_c5_g1_i1 P08361 POL_MLVCB 4.00E-09 GO:0015074; GO:0075713; GO:0046872; GO:0003676; GO:0046718 DNA integration; establishment of integrated proviral latency; metal ion binding; nucleic acid binding; viral entry into host cell IPR001584; IPR012337; Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Integrase p46 (IN)] (Fragment) gag-pol Cas-Br-E murine leukemia virus TR34781_c1_g1_i2 A6QLY2 GPX7_BOVIN 1.00E-44 GO:0005576; GO:0004602; GO:0006979 extracellular region; glutathione peroxidase activity; response to oxidative stress IPR013376; IPR000889; IPR012336; Glutathione peroxidase 7 (GPx-7) (GSHPx-7) (EC 1.11.1.9) GPX7 Bos taurus (Bovine) TR34782_c0_g2_i3 P09487 PPBT_BOVIN 2.00E-127 GO:0004035; GO:0031225; GO:0046872; GO:0005886; GO:0033280 alkaline phosphatase activity; anchored to membrane; metal ion binding; plasma membrane; response to vitamin D IPR017849; IPR001952; IPR018299; IPR017850; "Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)" ALPL Bos taurus (Bovine) TR34782_c0_g2_i4 P09487 PPBT_BOVIN 3.00E-73 GO:0004035; GO:0031225; GO:0046872; GO:0005886; GO:0033280 alkaline phosphatase activity; anchored to membrane; metal ion binding; plasma membrane; response to vitamin D IPR017849; IPR001952; IPR018299; IPR017850; "Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)" ALPL Bos taurus (Bovine) TR34783_c0_g1_i2 Q08DE2 T185A_BOVIN 5.00E-109 GO:0016021 integral to membrane IPR019396; Transmembrane protein 185B (Protein FAM11B) TMEM185B FAM11B Bos taurus (Bovine) TR34783_c0_g1_i3 Q5R8H8 T185A_PONAB 9.00E-27 GO:0030425; GO:0016021 dendrite; integral to membrane IPR019396; Transmembrane protein 185A (Protein FAM11A) TMEM185A FAM11A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34784_c2_g1_i1 O43310 CTIF_HUMAN 2.00E-36 GO:0003723; GO:0000184; GO:0048471; GO:0006446 "RNA binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; perinuclear region of cytoplasm; regulation of translational initiation" IPR016024; IPR016021; IPR003890; CBP80/20-dependent translation initiation factor CTIF KIAA0427 Homo sapiens (Human) TR34786_c1_g1_i5 Q6IDD9 SARM1_DROME 0 GO:0030424; GO:0005737; GO:0045087; GO:0043005; GO:0043025; GO:1901214; GO:0007165 axon; cytoplasm; innate immune response; neuron projection; neuronal cell body; regulation of neuron death; signal transduction IPR011989; IPR016024; IPR001660; IPR013761; IPR011510; IPR000157; Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog) (dSarm) Ect4 dsarm CG43119 Drosophila melanogaster (Fruit fly) TR34787_c1_g1_i1 Q9QXN5 MIOX_MOUSE 2.00E-112 GO:0050661; GO:0004033; GO:0005737; GO:0008199; GO:0016234; GO:0019310; GO:0050113; GO:0016651 "NADP binding; aldo-keto reductase (NADP) activity; cytoplasm; ferric iron binding; inclusion body; inositol catabolic process; inositol oxygenase activity; oxidoreductase activity, acting on NAD(P)H" IPR018170; IPR007828; Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1. Inositol oxygenase (EC 1.13.99.1) (Aldehyde reductase-like 6) (Myo-inositol oxygenase) (MI oxygenase) (Renal-specific oxidoreductase) Miox Aldrl6 Rsor Mus musculus (Mouse) TR34787_c1_g1_i2 Q9QXN5 MIOX_MOUSE 2.00E-112 GO:0050661; GO:0004033; GO:0005737; GO:0008199; GO:0016234; GO:0019310; GO:0050113; GO:0016651 "NADP binding; aldo-keto reductase (NADP) activity; cytoplasm; ferric iron binding; inclusion body; inositol catabolic process; inositol oxygenase activity; oxidoreductase activity, acting on NAD(P)H" IPR018170; IPR007828; Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1. Inositol oxygenase (EC 1.13.99.1) (Aldehyde reductase-like 6) (Myo-inositol oxygenase) (MI oxygenase) (Renal-specific oxidoreductase) Miox Aldrl6 Rsor Mus musculus (Mouse) TR34788_c1_g2_i4 Q5RJR2 TWF1_RAT 2.00E-131 GO:0015629; GO:0051016; GO:0005911; GO:0030175; GO:0030016; GO:0018108; GO:0048471; GO:0005546; GO:0004713; GO:0032587; GO:0042989 "actin cytoskeleton; barbed-end actin filament capping; cell-cell junction; filopodium; myofibril; peptidyl-tyrosine phosphorylation; perinuclear region of cytoplasm; phosphatidylinositol-4,5-bisphosphate binding; protein tyrosine kinase activity; ruffle membrane; sequestering of actin monomers" IPR002108; Twinfilin-1 Twf1 Ptk9 Rattus norvegicus (Rat) TR34793_c0_g1_i1 B2RYG8 ELP6_RAT 6.00E-44 GO:0033588; GO:0030335; GO:0006355; GO:0006351 "Elongator holoenzyme complex; positive regulation of cell migration; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR018627; Elongator complex protein 6 (Protein TMEM103) Elp6 Tmem103 Rattus norvegicus (Rat) TR34794_c0_g1_i1 Q9UIF3 TEKT2_HUMAN 5.00E-159 GO:0030030; GO:0001539; GO:0035085; GO:0005874; GO:0000226; GO:0030317 cell projection organization; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule cytoskeleton organization; sperm motility IPR000435; Tektin-2 (Tektin-t) (Testicular tektin) (Testicular tektin B1-like protein) (TEKTB1) (Tektin-B1) TEKT2 Homo sapiens (Human) TR34795_c1_g1_i1 P30028 DPOL_HPBDC 1.00E-06 GO:0003677; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0046872; GO:0090305; GO:0004523 DNA binding; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; ribonuclease H activity IPR001462; IPR000201; IPR000477; Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4)] P Duck hepatitis B virus (strain China) (DHBV) TR34796_c0_g1_i3 Q9V3C1 VHL_DROME 6.00E-06 GO:0030891; GO:0001525; GO:0030154; GO:0051297; GO:0007427; GO:0016334; GO:0035149; GO:0007026; GO:0005634; GO:0006611; GO:0016567; GO:1900037; GO:0090307; GO:0060438 Q7KRW1 "VCB complex; angiogenesis; cell differentiation; centrosome organization; epithelial cell migration, open tracheal system; establishment or maintenance of polarity of follicular epithelium; lumen formation, open tracheal system; negative regulation of microtubule depolymerization; nucleus; protein export from nucleus; protein ubiquitination; regulation of cellular response to hypoxia; spindle assembly involved in mitosis; trachea development" IPR002714; IPR024053; IPR022772; Protein modification; protein ubiquitination. Protein Vhl Vhl CG13221 Drosophila melanogaster (Fruit fly) TR34796_c0_g1_i4 P40338 VHL_MOUSE 4.00E-10 GO:0030891; GO:0001525; GO:0043534; GO:0005829; GO:0030198; GO:0016020; GO:0005739; GO:0070244; GO:0000122; GO:0030182; GO:0005634; GO:0010498; GO:0051291; GO:0016567; GO:2001233; GO:0042069; GO:0045471; GO:0001666 VCB complex; angiogenesis; blood vessel endothelial cell migration; cytosol; extracellular matrix organization; membrane; mitochondrion; negative regulation of thymocyte apoptotic process; negative regulation of transcription from RNA polymerase II promoter; neuron differentiation; nucleus; proteasomal protein catabolic process; protein heterooligomerization; protein ubiquitination; regulation of apoptotic signaling pathway; regulation of catecholamine metabolic process; response to ethanol; response to hypoxia IPR002714; IPR024048; IPR024053; IPR022772; Protein modification; protein ubiquitination. Von Hippel-Lindau disease tumor suppressor (pVHL) Vhl Vhlh Mus musculus (Mouse) TR34796_c0_g1_i6 P40338 VHL_MOUSE 2.00E-10 GO:0030891; GO:0001525; GO:0043534; GO:0005829; GO:0030198; GO:0016020; GO:0005739; GO:0070244; GO:0000122; GO:0030182; GO:0005634; GO:0010498; GO:0051291; GO:0016567; GO:2001233; GO:0042069; GO:0045471; GO:0001666 VCB complex; angiogenesis; blood vessel endothelial cell migration; cytosol; extracellular matrix organization; membrane; mitochondrion; negative regulation of thymocyte apoptotic process; negative regulation of transcription from RNA polymerase II promoter; neuron differentiation; nucleus; proteasomal protein catabolic process; protein heterooligomerization; protein ubiquitination; regulation of apoptotic signaling pathway; regulation of catecholamine metabolic process; response to ethanol; response to hypoxia IPR002714; IPR024048; IPR024053; IPR022772; Protein modification; protein ubiquitination. Von Hippel-Lindau disease tumor suppressor (pVHL) Vhl Vhlh Mus musculus (Mouse) TR34797_c0_g1_i1 A8Y183 NTAQ1_CAEBR 2.00E-39 GO:0016811 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides" IPR023128; Protein N-terminal glutamine amidohydrolase (EC 3.5.1.-) (Protein NH2-terminal glutamine deamidase) (N-terminal Gln amidase) (Nt(Q)-amidase) CBG21918 Caenorhabditis briggsae TR34797_c0_g1_i2 Q7Q968 NTAQ1_ANOGA 9.00E-60 GO:0016811 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides" IPR023128; Protein N-terminal glutamine amidohydrolase (EC 3.5.1.-) (Protein NH2-terminal glutamine deamidase) (N-terminal Gln amidase) (Nt(Q)-amidase) (Protein tungus) tun AGAP004865 Anopheles gambiae (African malaria mosquito) TR34797_c0_g1_i4 Q3T0D3 NTAQ1_BOVIN 8.00E-68 GO:0006464; GO:0005829; GO:0005634; GO:0070773 cellular protein modification process; cytosol; nucleus; protein-N-terminal glutamine amidohydrolase activity IPR023128; Protein N-terminal glutamine amidohydrolase (EC 3.5.1.-) (Protein NH2-terminal glutamine deamidase) (N-terminal Gln amidase) (Nt(Q)-amidase) (WDYHV motif-containing protein 1) WDYHV1 NTAQ1 Bos taurus (Bovine) TR34798_c0_g1_i1 P33527 MRP1_HUMAN 6.00E-28 GO:0005524; GO:0042626; GO:0005794; GO:0019369; GO:0009235; GO:0005887; GO:0006691; GO:0005634; GO:0042493 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; Golgi apparatus; arachidonic acid metabolic process; cobalamin metabolic process; integral to plasma membrane; leukotriene metabolic process; nucleus; response to drug" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP MRP1 Homo sapiens (Human) TR34799_c0_g2_i1 Q6DFA1 DCNL3_XENLA 1.00E-77 IPR014764; IPR005176; DCN1-like protein 3 (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3) dcun1d3 Xenopus laevis (African clawed frog) TR34800_c0_g1_i1 Q8VHK0 ACOT8_RAT 2.00E-89 GO:0047617; GO:0006637; GO:0004091; GO:0033882; GO:0005777; GO:0007031 acyl-CoA hydrolase activity; acyl-CoA metabolic process; carboxylesterase activity; choloyl-CoA hydrolase activity; peroxisome; peroxisome organization IPR003703; Acyl-coenzyme A thioesterase 8 (Acyl-CoA thioesterase 8) (EC 3.1.2.27) (Choloyl-coenzyme A thioesterase) (Peroxisomal acyl-CoA thioesterase 2) (PTE-2) (Peroxisomal acyl-coenzyme A thioester hydrolase 1) (PTE-1) (Peroxisomal long-chain acyl-CoA thioesterase 1) Acot8 Pte1 Pte2 Rattus norvegicus (Rat) TR34801_c0_g1_i1 P08548 LIN1_NYCCO 3.00E-32 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR34803_c0_g1_i2 Q91XQ5 CHSTF_MOUSE 1.00E-87 GO:0050656; GO:0000139; GO:0050659; GO:0019319; GO:0016021 3'-phosphoadenosine 5'-phosphosulfate binding; Golgi membrane; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity; hexose biosynthetic process; integral to membrane IPR027417; IPR000863; Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (B-cell RAG-associated gene protein) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST) Chst15 Brag Galnac4s6st Kiaa0598 Mus musculus (Mouse) TR34803_c0_g1_i5 Q91XQ5 CHSTF_MOUSE 1.00E-86 GO:0050656; GO:0000139; GO:0050659; GO:0019319; GO:0016021 3'-phosphoadenosine 5'-phosphosulfate binding; Golgi membrane; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity; hexose biosynthetic process; integral to membrane IPR027417; IPR000863; Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (B-cell RAG-associated gene protein) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST) Chst15 Brag Galnac4s6st Kiaa0598 Mus musculus (Mouse) TR34804_c2_g1_i1 P10394 POL4_DROME 9.00E-12 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR34804_c9_g1_i1 P03356 POL_MLVAV 2.00E-12 GO:0015074; GO:0006310; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0075713; GO:0090305; GO:0006508; GO:0004523; GO:0046718 DNA integration; DNA recombination; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; establishment of integrated proviral latency; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; viral entry into host cell IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR002156; IPR000477; Pol polyprotein [Cleaved into: Protease (EC 3.4.23.-); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 3.1.26.4); Integrase (IN)] pol AKV murine leukemia virus (AKR (endogenous) murine leukemia virus) TR34805_c1_g1_i1 P50540 MXI1_MOUSE 9.00E-17 GO:0003677; GO:0000122; GO:0005634; GO:0006351 "DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent" IPR011598; Max-interacting protein 1 (Max interactor 1) Mxi1 Mus musculus (Mouse) TR34805_c1_g1_i2 O09015 MXI1_RAT 7.00E-26 GO:0003677; GO:0005737; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cytoplasm; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011598; Max-interacting protein 1 (Max interactor 1) Mxi1 Rattus norvegicus (Rat) TR34806_c0_g1_i1 Q63HN8 RN213_HUMAN 5.00E-89 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR018957; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) TR34807_c5_g1_i2 Q6W3E9 P4HA3_RAT 2.00E-18 GO:0031418; GO:0005788; GO:0005506; GO:0016702; GO:0004656; GO:0016222 "L-ascorbic acid binding; endoplasmic reticulum lumen; iron ion binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; procollagen-proline 4-dioxygenase activity; procollagen-proline 4-dioxygenase complex" IPR005123; IPR006620; IPR013547; IPR011990; "Prolyl 4-hydroxylase subunit alpha-3 (4-PH alpha-3) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3)" P4ha3 Rattus norvegicus (Rat) TR34809_c2_g2_i1 Q5R8Z8 RAB14_PONAB 2.00E-136 GO:0019003; GO:0005525; GO:0003924; GO:0000139; GO:0006895; GO:0031901; GO:0009790; GO:0032456; GO:0008543; GO:0045335; GO:0030670; GO:0015031; GO:0055037; GO:0032880; GO:0007264 GDP binding; GTP binding; GTPase activity; Golgi membrane; Golgi to endosome transport; early endosome membrane; embryo development; endocytic recycling; fibroblast growth factor receptor signaling pathway; phagocytic vesicle; phagocytic vesicle membrane; protein transport; recycling endosome; regulation of protein localization; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-14 RAB14 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34809_c2_g2_i2 Q5R8Z8 RAB14_PONAB 2.00E-136 GO:0019003; GO:0005525; GO:0003924; GO:0000139; GO:0006895; GO:0031901; GO:0009790; GO:0032456; GO:0008543; GO:0045335; GO:0030670; GO:0015031; GO:0055037; GO:0032880; GO:0007264 GDP binding; GTP binding; GTPase activity; Golgi membrane; Golgi to endosome transport; early endosome membrane; embryo development; endocytic recycling; fibroblast growth factor receptor signaling pathway; phagocytic vesicle; phagocytic vesicle membrane; protein transport; recycling endosome; regulation of protein localization; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-14 RAB14 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34810_c3_g1_i2 Q640V9 TATD1_XENLA 1.00E-136 GO:0016888; GO:0046872; GO:0090305; GO:0005634 "endodeoxyribonuclease activity, producing 5'-phosphomonoesters; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleus" IPR018228; IPR001130; Putative deoxyribonuclease TATDN1 (EC 3.1.21.-) tatdn1 Xenopus laevis (African clawed frog) TR34810_c3_g1_i3 Q6P8M1 TATD1_MOUSE 4.00E-134 GO:0006309; GO:0005737; GO:0004536; GO:0016888; GO:0046872; GO:0005634 "apoptotic DNA fragmentation; cytoplasm; deoxyribonuclease activity; endodeoxyribonuclease activity, producing 5'-phosphomonoesters; metal ion binding; nucleus" IPR018228; IPR001130; Putative deoxyribonuclease TATDN1 (EC 3.1.21.-) Tatdn1 Mus musculus (Mouse) TR34811_c0_g1_i1 Q28CH2 CPEB3_XENTR 0 GO:0003723; GO:0030154; GO:0000166; GO:0048793 RNA binding; cell differentiation; nucleotide binding; pronephros development IPR012677; IPR000504; Cytoplasmic polyadenylation element-binding protein 3 (CPE-BP3) (CPE-binding protein 3) (CPEB-3) cpeb3 TGas021m22.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34811_c0_g2_i1 Q812E0 CPEB2_MOUSE 3.00E-117 GO:0005737; GO:0033125; GO:0045900; GO:0000166; GO:0008187; GO:0005844 cytoplasm; negative regulation of GTP catabolic process; negative regulation of translational elongation; nucleotide binding; poly-pyrimidine tract binding; polysome IPR012677; IPR000504; Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (mCPEB-2) Cpeb2 Mus musculus (Mouse) TR34812_c4_g1_i1 Q8CAQ8 IMMT_MOUSE 6.00E-83 GO:0016021; GO:0051560; GO:0005743 integral to membrane; mitochondrial calcium ion homeostasis; mitochondrial inner membrane IPR019133; Mitochondrial inner membrane protein (Mitofilin) Immt Mus musculus (Mouse) TR34812_c5_g3_i1 P52485 UBCD2_DROME 8.00E-95 GO:0005524; GO:0019915; GO:0004842 ATP binding; lipid storage; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2-24 kDa (EC 6.3.2.19) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) UbcD2 CG6720 Drosophila melanogaster (Fruit fly) TR34813_c1_g1_i2 O69060 HTXA_PSEST 3.00E-15 GO:0051213 dioxygenase activity IPR008775; Probable alpha-ketoglutarate-dependent hypophosphite dioxygenase (EC 1.-.-.-) htxA Pseudomonas stutzeri (Pseudomonas perfectomarina) TR34813_c1_g1_i3 Q7W977 ECTD_BORPA 6.00E-11 GO:0016725 "oxidoreductase activity, acting on CH or CH2 groups" IPR012774; IPR008775; Ectoine hydroxylase (EC 1.17.-.-) ectD BPP1891 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) TR34814_c1_g1_i1 Q8K2W6 PHF13_MOUSE 2.00E-29 GO:0051301; GO:0003682; GO:0016568; GO:0007076; GO:0005654; GO:0005634; GO:0008270 cell division; chromatin binding; chromatin modification; mitotic chromosome condensation; nucleoplasm; nucleus; zinc ion binding IPR011011; IPR001965; IPR019787; IPR013083; PHD finger protein 13 Phf13 Mus musculus (Mouse) TR34816_c2_g1_i1 Q28I03 CA109_XENTR 4.00E-10 Uncharacterized protein C1orf109 homolog TEgg082i12.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34816_c2_g1_i2 Q9NX04 CA109_HUMAN 3.00E-10 Uncharacterized protein C1orf109 C1orf109 Homo sapiens (Human) TR34817_c0_g1_i2 Q9CZV8 FXL20_MOUSE 2.00E-87 GO:0005737 Q99NE5 cytoplasm IPR001810; IPR006553; F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like) Fbxl20 Fbl2 Mus musculus (Mouse) TR34817_c1_g1_i1 Q9QZH7 FXL20_RAT 3.00E-65 GO:0005737 cytoplasm IPR001810; IPR006553; F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like) Fbxl20 Fbl2 Rattus norvegicus (Rat) TR34818_c0_g5_i1 Q99MB4 CBWD1_RAT 6.00E-132 GO:0005524 ATP binding IPR011629; IPR003495; IPR027417; COBW domain-containing protein 1 (Cobalamin synthase W domain-containing protein 1) Cbwd1 Rattus norvegicus (Rat) TR34819_c2_g2_i2 Q3BAI2 YCX91_PHAAO 2.00E-14 GO:0009507 chloroplast Uncharacterized protein ORF91 Phalaenopsis aphrodite subsp. formosana (Moth orchid) TR3482_c0_g1_i1 Q8CJ19 MICA3_MOUSE 4.00E-25 GO:0071949; GO:0003779; GO:0030042; GO:0005737; GO:0005856; GO:0006887; GO:0016709; GO:0008270 "FAD binding; actin binding; actin filament depolymerization; cytoplasm; cytoskeleton; exocytosis; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; zinc ion binding" IPR001715; IPR022735; IPR002938; IPR003042; IPR001781; Protein-methionine sulfoxide oxidase MICAL3 (EC 1.14.13.-) (Molecule interacting with CasL protein 3) (MICAL-3) Mical3 Kiaa0819 Kiaa1364 Mus musculus (Mouse) TR34820_c1_g1_i1 Q88UZ7 MUTS_LACPL 2.00E-56 GO:0005524; GO:0003684; GO:0006298; GO:0030983 ATP binding; damaged DNA binding; mismatch repair; mismatched DNA binding IPR005748; IPR007695; IPR000432; IPR007861; IPR007696; IPR016151; IPR007860; IPR027417; DNA mismatch repair protein MutS mutS hexA lp_2298 Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) TR34820_c1_g1_i3 O15457 MSH4_HUMAN 4.00E-164 GO:0005524; GO:0008094; GO:0051026; GO:0007292; GO:0045143; GO:0006298; GO:0030983; GO:0001541; GO:0007131; GO:0007283; GO:0000795 O43196 ATP binding; DNA-dependent ATPase activity; chiasma assembly; female gamete generation; homologous chromosome segregation; mismatch repair; mismatched DNA binding; ovarian follicle development; reciprocal meiotic recombination; spermatogenesis; synaptonemal complex IPR000432; IPR007861; IPR007696; IPR007860; IPR027417; MutS protein homolog 4 (hMSH4) MSH4 Homo sapiens (Human) TR34820_c1_g1_i4 P43248 MSH2_DROME 2.00E-44 GO:0005524; GO:0008094; GO:0032301; GO:0032302; GO:0000403; GO:0003684; GO:0006302; GO:0000406; GO:0000400; GO:0032137; GO:0031573; GO:0042771; GO:0000404; GO:0043570; GO:0006311; GO:0000710; GO:0045128; GO:0000228; GO:0006301; GO:0010224; GO:0010165; GO:0032138 ATP binding; DNA-dependent ATPase activity; MutSalpha complex; MutSbeta complex; Y-form DNA binding; damaged DNA binding; double-strand break repair; double-strand/single-strand DNA junction binding; four-way junction DNA binding; guanine/thymine mispair binding; intra-S DNA damage checkpoint; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; loop DNA binding; maintenance of DNA repeat elements; meiotic gene conversion; meiotic mismatch repair; negative regulation of reciprocal meiotic recombination; nuclear chromosome; postreplication repair; response to UV-B; response to X-ray; single base insertion or deletion binding IPR011184; IPR007695; IPR000432; IPR007861; IPR007696; IPR007860; IPR027417; DNA mismatch repair protein spellchecker 1 spel1 CG4215 Drosophila melanogaster (Fruit fly) TR34820_c1_g1_i5 O15457 MSH4_HUMAN 6.00E-154 GO:0005524; GO:0008094; GO:0051026; GO:0007292; GO:0045143; GO:0006298; GO:0030983; GO:0001541; GO:0007131; GO:0007283; GO:0000795 O43196 ATP binding; DNA-dependent ATPase activity; chiasma assembly; female gamete generation; homologous chromosome segregation; mismatch repair; mismatched DNA binding; ovarian follicle development; reciprocal meiotic recombination; spermatogenesis; synaptonemal complex IPR000432; IPR007861; IPR007696; IPR007860; IPR027417; MutS protein homolog 4 (hMSH4) MSH4 Homo sapiens (Human) TR34820_c1_g1_i6 B1LAW3 MUTS_THESQ 4.00E-63 GO:0005524; GO:0003684; GO:0006298; GO:0030983 ATP binding; damaged DNA binding; mismatch repair; mismatched DNA binding IPR005748; IPR007695; IPR000432; IPR007861; IPR007696; IPR016151; IPR007860; IPR027417; DNA mismatch repair protein MutS mutS TRQ2_1115 Thermotoga sp. (strain RQ2) TR34821_c0_g2_i1 Q8IUC8 GLT13_HUMAN 3.00E-102 GO:0000139; GO:0016266; GO:0016021; GO:0004653; GO:0043687 Golgi membrane; O-glycan processing; integral to membrane; polypeptide N-acetylgalactosaminyltransferase activity; post-translational protein modification IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 13 (EC 2.4.1.41) (Polypeptide GalNAc transferase 13) (GalNAc-T13) (pp-GaNTase 13) (Protein-UDP acetylgalactosaminyltransferase 13) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13) GALNT13 KIAA1918 Homo sapiens (Human) TR34822_c3_g1_i1 Q8IYU2 HACE1_HUMAN 6.00E-114 GO:0032580; GO:0000139; GO:0007030; GO:0017137; GO:0016601; GO:0007049; GO:0005783; GO:0061025; GO:0005634; GO:0070936; GO:0042787; GO:0030334; GO:0006355; GO:0006351; GO:0004842 "Golgi cisterna membrane; Golgi membrane; Golgi organization; Rab GTPase binding; Rac protein signal transduction; cell cycle; endoplasmic reticulum; membrane fusion; nucleus; protein K48-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of cell migration; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity" IPR002110; IPR020683; IPR000569; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HACE1 (EC 6.3.2.-) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) HACE1 KIAA1320 Homo sapiens (Human) TR34822_c5_g1_i2 Q8IYU2 HACE1_HUMAN 0 GO:0032580; GO:0000139; GO:0007030; GO:0017137; GO:0016601; GO:0007049; GO:0005783; GO:0061025; GO:0005634; GO:0070936; GO:0042787; GO:0030334; GO:0006355; GO:0006351; GO:0004842 "Golgi cisterna membrane; Golgi membrane; Golgi organization; Rab GTPase binding; Rac protein signal transduction; cell cycle; endoplasmic reticulum; membrane fusion; nucleus; protein K48-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of cell migration; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity" IPR002110; IPR020683; IPR000569; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HACE1 (EC 6.3.2.-) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) HACE1 KIAA1320 Homo sapiens (Human) TR34823_c0_g3_i1 O60662 KBTBA_HUMAN 5.00E-08 GO:0031463; GO:0031430; GO:0005813; GO:0030239; GO:0005730; GO:0005886; GO:0016567; GO:0031143; GO:0031275; GO:0045661; GO:2000291; GO:2001014; GO:0001726; GO:0035914; GO:0006941 P20929 Cul3-RING ubiquitin ligase complex; M band; centrosome; myofibril assembly; nucleolus; plasma membrane; protein ubiquitination; pseudopodium; regulation of lateral pseudopodium assembly; regulation of myoblast differentiation; regulation of myoblast proliferation; regulation of skeletal muscle cell differentiation; ruffle; skeletal muscle cell differentiation; striated muscle contraction IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 41 (Kel-like protein 23) (Kelch repeat and BTB domain-containing protein 10) (Kelch-related protein 1) (Sarcosin) KLHL41 KBTBD10 KRP1 Homo sapiens (Human) TR34823_c0_g3_i2 P28575 IPP_MOUSE 1.00E-08 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Actin-binding protein IPP (Intracisternal A particle-promoted polypeptide) (IPP) (Murine IAP-promoted placenta-expressed protein) (Protein MIPP) Ipp Mipp Mus musculus (Mouse) TR34827_c1_g1_i2 B0BNE5 ESTD_RAT 4.00E-159 GO:0005794; GO:0018738; GO:0004091; GO:0016023; GO:0046294; GO:0005634 Golgi apparatus; S-formylglutathione hydrolase activity; carboxylesterase activity; cytoplasmic membrane-bounded vesicle; formaldehyde catabolic process; nucleus IPR000801; IPR014186; S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) Esd Rattus norvegicus (Rat) TR34830_c1_g1_i1 Q9NBX4 RTXE_DROME 1.00E-17 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR34831_c6_g1_i1 Q8TD30 ALAT2_HUMAN 0 GO:0006103; GO:0042853; GO:0042851; GO:0004021; GO:0008652; GO:0034641; GO:0005759; GO:0030170 2-oxoglutarate metabolic process; L-alanine catabolic process; L-alanine metabolic process; L-alanine:2-oxoglutarate aminotransferase activity; cellular amino acid biosynthetic process; cellular nitrogen compound metabolic process; mitochondrial matrix; pyridoxal phosphate binding IPR004839; IPR015424; IPR015421; IPR015422; Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1. Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2) GPT2 AAT2 ALT2 Homo sapiens (Human) TR34833_c0_g2_i1 Q66GS9 CP135_HUMAN 4.00E-69 GO:0000086; GO:0005814; GO:0007099; GO:0010457; GO:0005829 Q9HC77; Q6UVJ0 G2/M transition of mitotic cell cycle; centriole; centriole replication; centriole-centriole cohesion; cytosol Centrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4) CEP135 CEP4 KIAA0635 Homo sapiens (Human) TR34833_c1_g1_i1 Q66GS9 CP135_HUMAN 3.00E-28 GO:0000086; GO:0005814; GO:0007099; GO:0010457; GO:0005829 Q9HC77; Q6UVJ0 G2/M transition of mitotic cell cycle; centriole; centriole replication; centriole-centriole cohesion; cytosol Centrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4) CEP135 CEP4 KIAA0635 Homo sapiens (Human) TR34834_c2_g2_i1 O35623 BET1_MOUSE 3.00E-07 GO:0006888; GO:0031985; GO:0000139; GO:0005801; GO:0005789; GO:0016021; GO:0015031; GO:0048280 ER to Golgi vesicle-mediated transport; Golgi cisterna; Golgi membrane; cis-Golgi network; endoplasmic reticulum membrane; integral to membrane; protein transport; vesicle fusion with Golgi apparatus IPR000727; BET1 homolog (mBET1) (Golgi vesicular membrane-trafficking protein p18) Bet1 Mus musculus (Mouse) TR34834_c2_g2_i3 Q68EL3 BET1L_DANRE 4.00E-17 GO:0000139; GO:0016021; GO:0015031 Golgi membrane; integral to membrane; protein transport IPR000727; BET1-like protein bet1l zgc:100789 Danio rerio (Zebrafish) (Brachydanio rerio) TR34835_c2_g1_i1 Q9GQN5 ATRX_DROME 4.00E-43 GO:0005524; GO:0016887; GO:0003677; GO:0006281; GO:0006336; GO:0007411; GO:0005722; GO:0042585; GO:0008347; GO:0004386; GO:0070868; GO:0097193; GO:0046328 ATP binding; ATPase activity; DNA binding; DNA repair; DNA replication-independent nucleosome assembly; axon guidance; beta-heterochromatin; germinal vesicle; glial cell migration; helicase activity; heterochromatin organization involved in chromatin silencing; intrinsic apoptotic signaling pathway; regulation of JNK cascade IPR014001; IPR001650; IPR027417; IPR000330; Transcriptional regulator ATRX homolog (EC 3.6.4.12) (ATP-dependent helicase XNP) (X-linked nuclear protein) (d-xnp) (dXNP) XNP CG4548 Drosophila melanogaster (Fruit fly) TR34835_c2_g1_i2 O12944 RAD54_CHICK 0 GO:0005524; GO:0003677; GO:0006281; GO:0036310; GO:0004386; GO:0005634 ATP binding; DNA binding; DNA repair; annealing helicase activity; helicase activity; nucleus IPR014001; IPR001650; IPR027417; IPR013967; IPR000330; DNA repair and recombination protein RAD54-like (EC 3.6.4.-) (Putative recombination factor GdRad54) (RAD54 homolog) (Fragment) RAD54L RAD54 Gallus gallus (Chicken) TR34835_c2_g1_i3 Q9JIM3 RAD26_MOUSE 2.00E-33 GO:0005524; GO:0008026; GO:0003677; GO:0006281; GO:0005737; GO:0005815; GO:0005634 ATP binding; ATP-dependent helicase activity; DNA binding; DNA repair; cytoplasm; microtubule organizing center; nucleus IPR002464; IPR014001; IPR001650; IPR027417; IPR000330; Putative DNA repair and recombination protein RAD26-like (EC 3.6.4.-) Rad26l Mus musculus (Mouse) TR34835_c2_g1_i4 Q9GQN5 ATRX_DROME 9.00E-44 GO:0005524; GO:0016887; GO:0003677; GO:0006281; GO:0006336; GO:0007411; GO:0005722; GO:0042585; GO:0008347; GO:0004386; GO:0070868; GO:0097193; GO:0046328 ATP binding; ATPase activity; DNA binding; DNA repair; DNA replication-independent nucleosome assembly; axon guidance; beta-heterochromatin; germinal vesicle; glial cell migration; helicase activity; heterochromatin organization involved in chromatin silencing; intrinsic apoptotic signaling pathway; regulation of JNK cascade IPR014001; IPR001650; IPR027417; IPR000330; Transcriptional regulator ATRX homolog (EC 3.6.4.12) (ATP-dependent helicase XNP) (X-linked nuclear protein) (d-xnp) (dXNP) XNP CG4548 Drosophila melanogaster (Fruit fly) TR34835_c2_g1_i5 O12944 RAD54_CHICK 0 GO:0005524; GO:0003677; GO:0006281; GO:0036310; GO:0004386; GO:0005634 ATP binding; DNA binding; DNA repair; annealing helicase activity; helicase activity; nucleus IPR014001; IPR001650; IPR027417; IPR013967; IPR000330; DNA repair and recombination protein RAD54-like (EC 3.6.4.-) (Putative recombination factor GdRad54) (RAD54 homolog) (Fragment) RAD54L RAD54 Gallus gallus (Chicken) TR34835_c4_g1_i1 Q1DKD8 DOT1_COCIM 9.00E-13 GO:0034968; GO:0018024; GO:0005634; GO:0006355; GO:0006351 "histone lysine methylation; histone-lysine N-methyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR013110; IPR025789; IPR021162; "Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase)" DOT1 CIMG_09225 Coccidioides immitis (strain RS) (Valley fever fungus) TR34835_c6_g1_i1 Q8TEK3 DOT1L_HUMAN 7.00E-52 GO:0003677; GO:0018024; GO:0005634; GO:0046425; GO:2000677 Q03111 DNA binding; histone-lysine N-methyltransferase activity; nucleus; regulation of JAK-STAT cascade; regulation of transcription regulatory region DNA binding IPR017956; IPR013110; IPR025789; IPR021169; "Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)" DOT1L KIAA1814 KMT4 Homo sapiens (Human) TR34836_c0_g1_i1 Q5E9H5 BCS1_BOVIN 0 GO:0005524; GO:0016021; GO:0005743; GO:0032981; GO:0034551; GO:0033617; GO:0017111 ATP binding; integral to membrane; mitochondrial inner membrane; mitochondrial respiratory chain complex I assembly; mitochondrial respiratory chain complex III assembly; mitochondrial respiratory chain complex IV assembly; nucleoside-triphosphatase activity IPR003593; IPR003959; IPR003960; IPR027243; IPR014851; IPR027417; Mitochondrial chaperone BCS1 (BCS1-like protein) BCS1L Bos taurus (Bovine) TR34836_c0_g1_i2 O34703 YJOB_BACSU 6.00E-16 GO:0005524; GO:0005737; GO:0017111 ATP binding; cytoplasm; nucleoside-triphosphatase activity IPR003593; IPR003959; IPR027417; Uncharacterized ATPase YjoB (EC 3.-.-.-) yjoB BSU12420 Bacillus subtilis (strain 168) TR34836_c0_g1_i3 Q5E9H5 BCS1_BOVIN 0 GO:0005524; GO:0016021; GO:0005743; GO:0032981; GO:0034551; GO:0033617; GO:0017111 ATP binding; integral to membrane; mitochondrial inner membrane; mitochondrial respiratory chain complex I assembly; mitochondrial respiratory chain complex III assembly; mitochondrial respiratory chain complex IV assembly; nucleoside-triphosphatase activity IPR003593; IPR003959; IPR003960; IPR027243; IPR014851; IPR027417; Mitochondrial chaperone BCS1 (BCS1-like protein) BCS1L Bos taurus (Bovine) TR34837_c3_g1_i1 Q8JZL3 THTPA_MOUSE 3.00E-18 GO:0005737; GO:0016311; GO:0046872; GO:0005730; GO:0050333; GO:0006772 cytoplasm; dephosphorylation; metal ion binding; nucleolus; thiamin-triphosphatase activity; thiamine metabolic process IPR023577; IPR012177; Thiamine-triphosphatase (ThTPase) (EC 3.6.1.28) Thtpa Mus musculus (Mouse) TR34837_c3_g1_i2 Q8JZL3 THTPA_MOUSE 3.00E-19 GO:0005737; GO:0016311; GO:0046872; GO:0005730; GO:0050333; GO:0006772 cytoplasm; dephosphorylation; metal ion binding; nucleolus; thiamin-triphosphatase activity; thiamine metabolic process IPR023577; IPR012177; Thiamine-triphosphatase (ThTPase) (EC 3.6.1.28) Thtpa Mus musculus (Mouse) TR34838_c2_g1_i2 Q4P2E8 ARP4_USTMA 1.00E-26 GO:0006281; GO:0016568; GO:0005634; GO:0006355; GO:0006351 "DNA repair; chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR004000; IPR004001; Actin-related protein 4 (Actin-like protein ARP4) (Actin-like protein 4) ARP4 UM05715 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR34838_c2_g1_i3 P10983 ACT1_CAEEL 0 TR34838_c2_g1_i4 P85937 ACT2_PSEMZ 1.00E-07 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; Actin-2 (Fragments) Pseudotsuga menziesii (Douglas-fir) (Abies menziesii) TR34838_c2_g1_i6 P85937 ACT2_PSEMZ 3.00E-07 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; Actin-2 (Fragments) Pseudotsuga menziesii (Douglas-fir) (Abies menziesii) TR34838_c2_g2_i1 P30170 ACT10_SOLTU 3.00E-82 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; Actin-85C (Fragment) AC85C Solanum tuberosum (Potato) TR34838_c2_g3_i1 Q964E2 ACTC_BIOPF 7.00E-140 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin, cytoplasmic" Biomphalaria pfeifferi (Bloodfluke planorb) (Freshwater snail) TR34841_c1_g1_i1 D3ZVR7 PGFS_RAT 4.00E-08 GO:0005829; GO:0016616; GO:0001516 "cytosol; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; prostaglandin biosynthetic process" IPR012336; Prostamide/prostaglandin F synthase (Prostamide/PG F synthase) (Prostamide/PGF synthase) (EC 1.11.1.20) Fam213b Rattus norvegicus (Rat) TR34841_c1_g1_i2 Q8AV19 CI021_TAKRU 2.00E-09 IPR012336; Thioredoxin-like protein AAED1 (AhpC/TSA antioxidant enzyme domain-containing protein 1) (fmHP) aaed1 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR34842_c0_g1_i2 Q96MM6 HS12B_HUMAN 4.00E-59 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR34843_c2_g1_i2 Q96EY9 ADAT3_HUMAN 3.00E-68 GO:0016787; GO:0008033; GO:0008270 hydrolase activity; tRNA processing; zinc ion binding IPR002125; IPR016193; Probable inactive tRNA-specific adenosine deaminase-like protein 3 (tRNA-specific adenosine-34 deaminase subunit ADAT3) ADAT3 TAD3 Homo sapiens (Human) TR34843_c2_g1_i3 Q7CQ08 TADA_SALTY 1.00E-14 GO:0016787; GO:0008033; GO:0008270 hydrolase activity; tRNA processing; zinc ion binding IPR016192; IPR002125; IPR016193; tRNA-specific adenosine deaminase (EC 3.5.4.33) tadA STM2568 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) TR34843_c2_g1_i5 Q8JFW4 ADAT3_DANRE 2.00E-45 GO:0016787; GO:0008033; GO:0008270 hydrolase activity; tRNA processing; zinc ion binding IPR002125; IPR016193; Probable inactive tRNA-specific adenosine deaminase-like protein 3 (tRNA-specific adenosine-34 deaminase subunit adat3) adat3 si:busm1-72b14.5 si:dkey-204g5.2 zgc:103555 Danio rerio (Zebrafish) (Brachydanio rerio) TR34847_c0_g3_i1 F6S215 AP5B1_XENTR 3.00E-27 GO:0030119; GO:0016197; GO:0015031 AP-type membrane coat adaptor complex; endosomal transport; protein transport AP-5 complex subunit beta-1 (Adapter-related protein complex 5 beta subunit) (Beta5) ap5b1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34847_c0_g3_i2 F6S215 AP5B1_XENTR 9.00E-13 GO:0030119; GO:0016197; GO:0015031 AP-type membrane coat adaptor complex; endosomal transport; protein transport AP-5 complex subunit beta-1 (Adapter-related protein complex 5 beta subunit) (Beta5) ap5b1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34848_c0_g2_i1 P51949 MAT1_MOUSE 2.00E-114 GO:0008094; GO:0008353; GO:0007512; GO:0007049; GO:0005675; GO:0045944; GO:0006355; GO:0051592; GO:0006366; GO:0021591; GO:0008270 "DNA-dependent ATPase activity; RNA polymerase II carboxy-terminal domain kinase activity; adult heart development; cell cycle; holo TFIIH complex; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to calcium ion; transcription from RNA polymerase II promoter; ventricular system development; zinc ion binding" IPR015877; IPR004575; IPR003903; IPR001841; IPR013083; IPR017907; CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Menage a trois) (RING finger protein MAT1) (p35) (p36) Mnat1 Mat1 Mus musculus (Mouse) TR34849_c5_g2_i1 Q2MV58 TECT1_HUMAN 1.00E-32 GO:0036038; GO:0021956; GO:0060271; GO:0005737; GO:0021904; GO:0005615; GO:0001701; GO:0016020; GO:0005932; GO:0001841; GO:0008589; GO:0021523; GO:0021537 TCTN-B9D complex; central nervous system interneuron axonogenesis; cilium morphogenesis; cytoplasm; dorsal/ventral neural tube patterning; extracellular space; in utero embryonic development; membrane; microtubule basal body; neural tube formation; regulation of smoothened signaling pathway; somatic motor neuron differentiation; telencephalon development IPR011677; Tectonic-1 TCTN1 TECT1 UNQ9369/PRO34160 Homo sapiens (Human) TR34853_c0_g1_i1 Q63ZU0 ADA_XENTR 1.00E-100 GO:0042110; GO:0006154; GO:0004000; GO:0030054; GO:0060205; GO:0005829; GO:0009897; GO:0043103; GO:0046103; GO:0060169; GO:0009117; GO:0009168; GO:0008270 T cell activation; adenosine catabolic process; adenosine deaminase activity; cell junction; cytoplasmic membrane-bounded vesicle lumen; cytosol; external side of plasma membrane; hypoxanthine salvage; inosine biosynthetic process; negative regulation of adenosine receptor signaling pathway; nucleotide metabolic process; purine ribonucleoside monophosphate biosynthetic process; zinc ion binding IPR006650; IPR001365; IPR006330; Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) ada Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34853_c0_g1_i2 B9JYP8 ADE_AGRVS 7.00E-14 GO:0006146; GO:0000034; GO:0043103; GO:0009117; GO:0009168; GO:0008270 adenine catabolic process; adenine deaminase activity; hypoxanthine salvage; nucleotide metabolic process; purine ribonucleoside monophosphate biosynthetic process; zinc ion binding IPR001365; IPR006330; Adenine deaminase (ADE) (EC 3.5.4.2) (Adenine aminohydrolase) (AAH) Avi_0230 Agrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4)) TR34853_c0_g1_i3 Q92T48 ADE_RHIME 5.00E-14 GO:0006146; GO:0000034; GO:0043103; GO:0009117; GO:0009168; GO:0008270 adenine catabolic process; adenine deaminase activity; hypoxanthine salvage; nucleotide metabolic process; purine ribonucleoside monophosphate biosynthetic process; zinc ion binding IPR001365; IPR006330; Adenine deaminase (ADE) (EC 3.5.4.2) (Adenine aminohydrolase) (AAH) R00132 SMc04120 Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) TR34854_c1_g1_i2 P10039 TENA_CHICK 3.00E-22 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) TNC Gallus gallus (Chicken) TR34854_c1_g1_i4 Q29042 FCN1_PIG 2.00E-18 GO:0005581; GO:0045087; GO:0046872 collagen; innate immune response; metal ion binding IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Ficolin-A) (Ficolin-alpha) FCN1 Sus scrofa (Pig) TR34854_c1_g1_i5 P21520 SCA_DROME 2.00E-13 GO:0007219; GO:0007460; GO:0005576; GO:0016321; GO:0008587; GO:0005770; GO:0046331; GO:0016318; GO:0045468; GO:0097305; GO:0004871 Notch signaling pathway; R8 cell fate commitment; extracellular region; female meiosis chromosome segregation; imaginal disc-derived wing margin morphogenesis; late endosome; lateral inhibition; ommatidial rotation; regulation of R8 cell spacing in compound eye; response to alcohol; signal transducer activity IPR014716; IPR014715; IPR002181; IPR020837; Protein scabrous sca CG17579 Drosophila melanogaster (Fruit fly) TR34854_c2_g1_i7 E2IYB3 FCNV1_VARKO 1.00E-09 GO:0005576 extracellular region IPR008160; IPR014716; IPR002181; Veficolin-1 (Fragment) Varanus komodoensis (Komodo dragon) TR34854_c2_g3_i1 A0A8J8 ANGP2_CANFA 9.00E-09 GO:0048014; GO:0001525; GO:0030154; GO:0005615; GO:0046872; GO:0016525; GO:0043537; GO:0010812; GO:0050928 Tie signaling pathway; angiogenesis; cell differentiation; extracellular space; metal ion binding; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of cell-substrate adhesion; negative regulation of positive chemotaxis IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-2 (ANG-2) ANGPT2 Canis familiaris (Dog) (Canis lupus familiaris) TR34854_c2_g4_i1 Q00546 TENR_CHICK 9.00E-32 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR013032; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin-R (TN-R) (Restrictin) TNR Gallus gallus (Chicken) TR34854_c2_g4_i3 E2IYB3 FCNV1_VARKO 1.00E-19 GO:0005576 extracellular region IPR008160; IPR014716; IPR002181; Veficolin-1 (Fragment) Varanus komodoensis (Komodo dragon) TR34855_c1_g1_i1 P33731 SRP72_CANFA 3.00E-146 GO:0008312; GO:0006614; GO:0005829; GO:0005783; GO:0005730; GO:0005886; GO:0042493; GO:0005047; GO:0005786 "7S RNA binding; SRP-dependent cotranslational protein targeting to membrane; cytosol; endoplasmic reticulum; nucleolus; plasma membrane; response to drug; signal recognition particle binding; signal recognition particle, endoplasmic reticulum targeting" IPR013699; IPR026270; IPR013026; IPR011990; IPR001440; IPR019734; Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein) SRP72 Canis familiaris (Dog) (Canis lupus familiaris) TR34857_c0_g1_i1 O60015 UBCX_PICAN 3.00E-16 GO:0005524; GO:0007031; GO:0004842 ATP binding; peroxisome organization; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2-21 kDa (EC 6.3.2.19) (Peroxin-4) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) PEX4 Pichia angusta (Yeast) (Hansenula polymorpha) TR34857_c0_g1_i2 P61078 UB2D3_RAT 9.00E-58 GO:0005524; GO:0006281; GO:0006915; GO:0010008; GO:0005886; GO:0043161; GO:0070979; GO:0070936; GO:0004842 ATP binding; DNA repair; apoptotic process; endosome membrane; plasma membrane; proteasomal ubiquitin-dependent protein catabolic process; protein K11-linked ubiquitination; protein K48-linked ubiquitination; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 D3 (EC 6.3.2.19) (Phosphoarginine phosphatase) (PAPase) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) Ube2d3 Rattus norvegicus (Rat) TR34857_c0_g1_i6 P25865 UBC1_ARATH 5.00E-29 GO:0005524; GO:0033523; GO:0009965; GO:0009910; GO:0006511; GO:0004842; GO:0010228 ATP binding; histone H2B ubiquitination; leaf morphogenesis; negative regulation of flower development; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; vegetative to reproductive phase transition of meristem IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 1 (EC 6.3.2.19) (Ubiquitin carrier protein 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase 1) UBC1 At1g14400 F14L17.17 F14L17_35 Arabidopsis thaliana (Mouse-ear cress) TR34857_c0_g1_i7 P61078 UB2D3_RAT 5.00E-58 GO:0005524; GO:0006281; GO:0006915; GO:0010008; GO:0005886; GO:0043161; GO:0070979; GO:0070936; GO:0004842 ATP binding; DNA repair; apoptotic process; endosome membrane; plasma membrane; proteasomal ubiquitin-dependent protein catabolic process; protein K11-linked ubiquitination; protein K48-linked ubiquitination; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 D3 (EC 6.3.2.19) (Phosphoarginine phosphatase) (PAPase) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) Ube2d3 Rattus norvegicus (Rat) TR34863_c2_g1_i1 O00505 IMA3_HUMAN 4.00E-38 GO:0006607; GO:0019221; GO:0005829; GO:0019048; GO:0008139; GO:0005643; GO:0005654; GO:0006461; GO:0008565; GO:0046718; GO:0075732 P46527; Q8K4J6 NLS-bearing protein import into nucleus; cytokine-mediated signaling pathway; cytosol; modulation by virus of host morphology or physiology; nuclear localization sequence binding; nuclear pore; nucleoplasm; protein complex assembly; protein transporter activity; viral entry into host cell; viral penetration into host nucleus IPR011989; IPR016024; IPR000225; IPR002652; IPR024931; Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma) KPNA3 QIP2 Homo sapiens (Human) TR34864_c4_g1_i1 P18425 SCR20_OMMSL 8.00E-13 GO:0005212 structural constituent of eye lens IPR010987; IPR004045; IPR004046; IPR003083; IPR012336; S-crystallin SL20-1 (Major lens polypeptide) Ommastrephes sloanei (Arrow squid) (Sloane's squid) TR34864_c4_g1_i2 P24472 GSTA4_MOUSE 3.00E-50 GO:0005737; GO:0006749; GO:0004364 cytoplasm; glutathione metabolic process; glutathione transferase activity IPR010987; IPR004045; IPR003080; IPR004046; IPR012336; Glutathione S-transferase A4 (EC 2.5.1.18) (GST A4-4) (GSTA4-4) (GST class-alpha member 4) (Glutathione S-transferase 5.7) (GST 5.7) Gsta4 Gsta Mus musculus (Mouse) TR34864_c4_g1_i3 Q09607 GST36_CAEEL 4.00E-19 GO:0004364 glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Probable glutathione S-transferase gst-36 (EC 2.5.1.18) (GST class-sigma) gst-36 R07B1.4 Caenorhabditis elegans TR34864_c4_g1_i5 O16115 GST2_CAEEL 1.00E-13 GO:0004364 glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase 2 (EC 2.5.1.18) (CeGST2) (GST class-sigma) gst-2 K08F4.6 Caenorhabditis elegans TR34866_c3_g5_i2 Q9VCA2 ORCT_DROME 2.00E-13 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR34867_c0_g1_i2 Q49AM3 TTC31_HUMAN 1.00E-12 IPR013026; IPR011990; IPR013105; IPR019734; Tetratricopeptide repeat protein 31 (TPR repeat protein 31) TTC31 Homo sapiens (Human) TR34867_c0_g1_i3 P31948 STIP1_HUMAN 0 GO:0005794; GO:0005634; GO:0043234; GO:0006950 P00533 Golgi apparatus; nucleus; protein complex; response to stress IPR006636; IPR013026; IPR011990; IPR001440; IPR019734; Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) STIP1 Homo sapiens (Human) TR34867_c0_g1_i4 Q68FQ7 RPAP3_RAT 7.00E-17 IPR025986; IPR013026; IPR011990; IPR001440; IPR019734; RNA polymerase II-associated protein 3 Rpap3 Rattus norvegicus (Rat) TR34868_c0_g1_i1 Q9D1C9 RRP7A_MOUSE 2.00E-68 GO:0003723; GO:0000166 RNA binding; nucleotide binding IPR012677; IPR024326; Ribosomal RNA-processing protein 7 homolog A (Gastric cancer antigen Zg14 homolog) Rrp7a Mus musculus (Mouse) TR34870_c1_g1_i1 Q6PJW8 CNST_HUMAN 4.00E-08 GO:0005794; GO:0071253; GO:0016021; GO:0010923; GO:0019902; GO:0005886; GO:0042998; GO:0043234; GO:0005802; GO:0030133 P62136 Golgi apparatus; connexin binding; integral to membrane; negative regulation of phosphatase activity; phosphatase binding; plasma membrane; positive regulation of Golgi to plasma membrane protein transport; protein complex; trans-Golgi network; transport vesicle IPR028129; Consortin CNST C1orf71 Homo sapiens (Human) TR34871_c2_g1_i1 O16963 NH130_CAEEL 2.00E-06 GO:0005634; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR001628; IPR013088; Nuclear hormone receptor family member nhr-130 nhr-130 T01G6.8 Caenorhabditis elegans TR34871_c2_g1_i2 P16376 7UP2_DROME 6.00E-71 GO:0007462; GO:0007464; GO:0007465; GO:0001078; GO:0007510; GO:0005737; GO:0061331; GO:0007503; GO:0004879; GO:0007270; GO:0005634; GO:0042331; GO:0043565; GO:0003707; GO:0007419; GO:0007601; GO:0008270 R1/R6 cell fate commitment; R3/R4 cell fate commitment; R7 cell fate commitment; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; cardioblast cell fate determination; cytoplasm; epithelial cell proliferation involved in Malpighian tubule morphogenesis; fat body development; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; neuron-neuron synaptic transmission; nucleus; phototaxis; sequence-specific DNA binding; steroid hormone receptor activity; ventral cord development; visual perception; zinc ion binding IPR003068; IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; "Steroid receptor seven-up, isoform A (Nuclear receptor subfamily 2 group F member 3, isoform A)" svp NR2F3 CG11502 Drosophila melanogaster (Fruit fly) TR34871_c2_g2_i1 O09018 COT2_RAT 4.00E-134 GO:0009952; GO:0048514; GO:0009566; GO:0030900; GO:0004879; GO:0060173; GO:0001893; GO:0045736; GO:0010596; GO:0001937; GO:0000122; GO:0001764; GO:0005634; GO:0060674; GO:0045893; GO:0009956; GO:0060849; GO:0032355; GO:0001972; GO:0043565; GO:0007519; GO:0003707; GO:0060707; GO:0008270 "anterior/posterior pattern specification; blood vessel morphogenesis; fertilization; forebrain development; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; limb development; maternal placenta development; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter; neuron migration; nucleus; placenta blood vessel development; positive regulation of transcription, DNA-dependent; radial pattern formation; regulation of transcription involved in lymphatic endothelial cell fate commitment; response to estradiol stimulus; retinoic acid binding; sequence-specific DNA binding; skeletal muscle tissue development; steroid hormone receptor activity; trophoblast giant cell differentiation; zinc ion binding" IPR003068; IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; COUP transcription factor 2 (COUP-TF2) (Apolipoprotein A-I regulatory protein 1) (ARP-1) (COUP transcription factor II) (COUP-TF II) (COUPb) (Nuclear receptor subfamily 2 group F member 2) (Ovalbumin upstream promoter beta nuclear receptor) Nr2f2 Arp1 Tfcoup2 Rattus norvegicus (Rat) TR34871_c2_g2_i2 O09018 COT2_RAT 4.00E-134 GO:0009952; GO:0048514; GO:0009566; GO:0030900; GO:0004879; GO:0060173; GO:0001893; GO:0045736; GO:0010596; GO:0001937; GO:0000122; GO:0001764; GO:0005634; GO:0060674; GO:0045893; GO:0009956; GO:0060849; GO:0032355; GO:0001972; GO:0043565; GO:0007519; GO:0003707; GO:0060707; GO:0008270 "anterior/posterior pattern specification; blood vessel morphogenesis; fertilization; forebrain development; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; limb development; maternal placenta development; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter; neuron migration; nucleus; placenta blood vessel development; positive regulation of transcription, DNA-dependent; radial pattern formation; regulation of transcription involved in lymphatic endothelial cell fate commitment; response to estradiol stimulus; retinoic acid binding; sequence-specific DNA binding; skeletal muscle tissue development; steroid hormone receptor activity; trophoblast giant cell differentiation; zinc ion binding" IPR003068; IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; COUP transcription factor 2 (COUP-TF2) (Apolipoprotein A-I regulatory protein 1) (ARP-1) (COUP transcription factor II) (COUP-TF II) (COUPb) (Nuclear receptor subfamily 2 group F member 2) (Ovalbumin upstream promoter beta nuclear receptor) Nr2f2 Arp1 Tfcoup2 Rattus norvegicus (Rat) TR34874_c1_g1_i1 P82596 PLC_HALLA 3.00E-08 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR34874_c2_g1_i1 Q6P0U3 RSLBB_DANRE 5.00E-30 GO:0005525; GO:0003924; GO:0016020; GO:0048382; GO:0007264 GTP binding; GTPase activity; membrane; mesendoderm development; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; Ras-like protein family member 11B rasl11b Danio rerio (Zebrafish) (Brachydanio rerio) TR34874_c2_g1_i2 P34143 RABC_DICDI 7.00E-10 GO:0005525; GO:0005886; GO:0015031; GO:0007264 GTP binding; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein RabC rabC DDB_G0271736 Dictyostelium discoideum (Slime mold) TR34874_c2_g1_i3 Q6P0U3 RSLBB_DANRE 1.00E-30 GO:0005525; GO:0003924; GO:0016020; GO:0048382; GO:0007264 GTP binding; GTPase activity; membrane; mesendoderm development; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; Ras-like protein family member 11B rasl11b Danio rerio (Zebrafish) (Brachydanio rerio) TR34875_c1_g1_i1 Q4UMH6 Y381_RICFE 1.00E-19 GO:0015969 guanosine tetraphosphate metabolic process IPR002110; IPR020683; IPR007685; Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR34876_c0_g1_i1 Q0P4X6 ZBT44_XENTR 8.00E-06 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 44 zbtb44 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34878_c0_g1_i1 O15156 ZBT7B_HUMAN 1.00E-15 GO:0003677; GO:0030154; GO:0007398; GO:0046872; GO:0007275; GO:0005634; GO:0045944; GO:0043370; GO:0043376; GO:0003700; GO:0006366 "DNA binding; cell differentiation; ectoderm development; metal ion binding; multicellular organismal development; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of CD4-positive, alpha-beta T cell differentiation; regulation of CD8-positive, alpha-beta T cell differentiation; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK) ZBTB7B ZBTB15 ZFP67 ZNF857B Homo sapiens (Human) TR34878_c2_g1_i1 P45447 E78C_DROME 6.00E-29 GO:0004879; GO:0005634; GO:0043565; GO:0003707; GO:0008270 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleus; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Ecdysone-induced protein 78C (DR-78) (Nuclear receptor subfamily 1 group E member 1) Eip78C NR1E1 CG18023 Drosophila melanogaster (Fruit fly) TR34879_c0_g1_i1 Q02040 AK17A_HUMAN 4.00E-79 GO:0042113; GO:0003723; GO:0008380; GO:0006397; GO:0016607; GO:0000166; GO:0051018; GO:0043484; GO:0006355; GO:0007165; GO:0005681 O95218 "B cell activation; RNA binding; RNA splicing; mRNA processing; nuclear speck; nucleotide binding; protein kinase A binding; regulation of RNA splicing; regulation of transcription, DNA-dependent; signal transduction; spliceosomal complex" IPR012677; "A-kinase anchor protein 17A (AKAP-17A) (721P) (B-lymphocyte antigen) (Protein XE7) (Protein kinase A-anchoring protein 17A) (PRKA17A) (Splicing factor, arginine/serine-rich 17A)" AKAP17A CXYorf3 DXYS155E SFRS17A XE7 Homo sapiens (Human) TR34881_c1_g1_i1 Q8TGR5 YE030_YEAST 1.00E-07 Putative uncharacterized protein YEL030C-A YEL030C-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR34881_c1_g1_i2 A5N6M2 DNAK_CLOK5 4.00E-88 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK CKL_0902 Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) TR34881_c2_g2_i1 Q16956 GRP78_APLCA 0 GO:0005524; GO:0005788 ATP binding; endoplasmic reticulum lumen IPR018181; IPR013126; 78 kDa glucose-regulated protein (GRP-78) (BiP) (Protein 1603) Aplysia californica (California sea hare) TR34881_c2_g2_i2 Q16956 GRP78_APLCA 0 GO:0005524; GO:0005788 ATP binding; endoplasmic reticulum lumen IPR018181; IPR013126; 78 kDa glucose-regulated protein (GRP-78) (BiP) (Protein 1603) Aplysia californica (California sea hare) TR34881_c2_g3_i1 A0RZ01 DNAK_CENSY 7.00E-75 GO:0005524; GO:0006457 ATP binding; protein folding IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK CENSYa_1961 Cenarchaeum symbiosum (strain A) TR34881_c2_g3_i3 P34935 GRP78_PIG 1.00E-139 GO:0005524; GO:0005788; GO:0042470 ATP binding; endoplasmic reticulum lumen; melanosome IPR018181; IPR013126; 78 kDa glucose-regulated protein (GRP-78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP) (Fragment) HSPA5 GRP78 Sus scrofa (Pig) TR34881_c2_g3_i4 P16121 HSP70_LUPPO 9.00E-82 GO:0005524; GO:0006950 ATP binding; response to stress IPR013126; Heat shock 70 kDa protein (Fragment) Lupinus polyphyllus (Large-leaved lupin) TR34882_c0_g2_i1 Q5TCS8 AKD1_HUMAN 0 GO:0006757; GO:0006756; GO:0005524; GO:0061508; GO:0061566; GO:0061568; GO:0061571; GO:0061569; GO:0005737; GO:0006174; GO:0061565; GO:0061570; GO:0061567; GO:0006186; GO:0004550; GO:0050145; GO:0017111; GO:0005634 ADP phosphorylation; AMP phosphorylation; ATP binding; CDP phosphorylation; CMP phosphorylation; GDP phosphorylation; TDP phosphorylation; UDP phosphorylation; cytoplasm; dADP phosphorylation; dAMP phosphorylation; dCDP phosphorylation; dCMP phosphorylation; dGDP phosphorylation; nucleoside diphosphate kinase activity; nucleoside phosphate kinase activity; nucleoside-triphosphatase activity; nucleus IPR003593; IPR000850; IPR027417; IPR007029; Adenylate kinase 9 (AK 9) (EC 2.7.4.4) (EC 2.7.4.6) (Adenylate kinase domain-containing protein 1) (Adenylate kinase domain-containing protein 2) AK9 AKD1 AKD2 C6orf199 C6orf224 Homo sapiens (Human) TR34883_c0_g1_i1 Q96PM5 ZN363_HUMAN 1.00E-79 GO:0005737; GO:0016607; GO:0005634; GO:0032436; GO:0031398; GO:0051865; GO:0042787; GO:0000151; GO:0004842; GO:0008270 Q9NVV5; P18085; Q6UXH0; P62158; P04196; Q969F2; Q9UBE8; P04637 cytoplasm; nuclear speck; nucleus; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; protein autoubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin ligase complex; ubiquitin-protein ligase activity; zinc ion binding IPR004039; IPR008913; IPR017921; IPR001841; IPR013083; Protein modification; protein ubiquitination. RING finger and CHY zinc finger domain-containing protein 1 (EC 6.3.2.-) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (Zinc finger protein 363) (p53-induced RING-H2 protein) (hPirh2) RCHY1 ARNIP CHIMP PIRH2 RNF199 ZNF363 Homo sapiens (Human) TR34884_c1_g2_i1 Q8S8T8 PCR10_ARATH 1.00E-10 GO:0016021 integral to membrane IPR006461; Protein PLANT CADMIUM RESISTANCE 10 (AtPCR10) PCR10 At2g40935 T20B5 Arabidopsis thaliana (Mouse-ear cress) TR34884_c1_g2_i3 O57592 RL7A_TAKRU 5.00E-127 GO:0005840; GO:0042254 ribosome; ribosome biogenesis IPR001921; IPR004038; IPR018492; IPR004037; 60S ribosomal protein L7a (Surfeit locus protein 3) rpl7a surf3 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR34884_c1_g2_i4 Q9LQU2 PCR1_ARATH 4.00E-08 GO:0016021; GO:0005886; GO:0005773 integral to membrane; plasma membrane; vacuole IPR006461; Protein PLANT CADMIUM RESISTANCE 1 (AtPCR1) PCR1 At1g14880 F10B6.29 Arabidopsis thaliana (Mouse-ear cress) TR34884_c1_g2_i5 Q6DK93 CNFN_XENTR 1.00E-10 IPR006461; Cornifelin homolog cnfn TNeu057a17.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR34886_c0_g1_i1 P18870 JUN_CHICK 3.00E-50 GO:0002755; GO:0035419; GO:0045087; GO:0005634; GO:0043565; GO:0003700; GO:0035681; GO:0034134; GO:0035682; GO:0034138; GO:0034142; GO:0034146; GO:0034154; GO:0006351 "MyD88-dependent toll-like receptor signaling pathway; activation of MAPK activity involved in innate immune response; innate immune response; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; toll-like receptor 15 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 21 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 7 signaling pathway; transcription, DNA-dependent" IPR004827; IPR015558; IPR005643; IPR002112; IPR008917; Transcription factor AP-1 (Proto-oncogene c-Jun) JUN Gallus gallus (Chicken) TR34890_c2_g1_i2 Q8N539 FBCD1_HUMAN 1.00E-60 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 UNQ701/PRO1346 Homo sapiens (Human) TR34890_c4_g1_i1 Q9DF50 CLSPN_XENLA 3.00E-09 GO:0003677; GO:0006281; GO:0031572; GO:0005634 DNA binding; DNA repair; G2 DNA damage checkpoint; nucleus IPR024147; IPR024146; Claspin (xClaspin) clspn Xenopus laevis (African clawed frog) TR34892_c4_g1_i2 P0CE10 Y4102_ARATH 3.00E-30 GO:0005524; GO:0008026; GO:0003723; GO:0009507; GO:0008270 ATP binding; ATP-dependent helicase activity; RNA binding; chloroplast; zinc ion binding IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR004087; IPR027417; IPR007087; IPR015880; IPR018957; IPR002867; IPR001841; IPR013083; IPR017907; "Putative uncharacterized protein At4g01020, chloroplastic" At4g01020 F3I3.40 Arabidopsis thaliana (Mouse-ear cress) TR34892_c4_g1_i3 Q9LVW9 ARI4_ARATH 8.00E-10 GO:0016874; GO:0016567; GO:0008270 ligase activity; protein ubiquitination; zinc ion binding IPR002867; IPR001841; IPR013083; Protein modification; protein ubiquitination. Putative E3 ubiquitin-protein ligase ARI4 (EC 6.3.2.-) (ARIADNE-like protein ARI4) (Protein ariadne homolog 4) ARI4 At3g27720 MGF10.12 Arabidopsis thaliana (Mouse-ear cress) TR34892_c5_g1_i1 Q20875 DHX15_CAEEL 1.00E-08 GO:0030686; GO:0005524; GO:0004004; GO:0008380; GO:0006397; GO:0005739; GO:0003676; GO:0005634; GO:0006364 90S preribosome; ATP binding; ATP-dependent RNA helicase activity; RNA splicing; mRNA processing; mitochondrion; nucleic acid binding; nucleus; rRNA processing IPR003593; IPR011545; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Putative pre-mRNA-splicing factor ATP-dependent RNA helicase F56D2.6 (EC 3.6.4.13) F56D2.6 Caenorhabditis elegans TR34893_c2_g2_i1 P86854 PLCL_MYTGA 5.00E-19 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR34896_c1_g2_i1 Q4UMH6 Y381_RICFE 4.00E-22 GO:0015969 guanosine tetraphosphate metabolic process IPR002110; IPR020683; IPR007685; Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR34896_c1_g3_i1 Q8VE42 ANR49_MOUSE 4.00E-09 GO:0045893 "positive regulation of transcription, DNA-dependent" IPR002110; IPR020683; Ankyrin repeat domain-containing protein 49 (Fetal globin-increasing factor) (Fetal globin-inducing factor) Ankrd49 Fgif Gbif Mus musculus (Mouse) TR34896_c12_g1_i4 Q5RBR6 SPRY3_PONAB 3.00E-28 IPR001870; IPR008985; IPR018355; IPR003877; SPRY domain-containing protein 3 SPRYD3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34896_c4_g1_i1 B0G124 Y9043_DICDI 1.00E-11 IPR002110; IPR020683; Ankyrin repeat-containing protein DDB_G0279043 DDB_G0279043 Dictyostelium discoideum (Slime mold) TR34897_c3_g1_i1 P82596 PLC_HALLA 2.00E-14 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR34899_c1_g1_i1 Q9D9B4 CJ011_MOUSE 7.00E-67 GO:0030318 melanocyte differentiation IPR001611; IPR003603; Leucine-rich repeat-containing protein C10orf11 homolog Mus musculus (Mouse) TR34902_c2_g1_i1 Q96WV9 CDK9_SCHPO 5.00E-06 GO:0005524; GO:0070693; GO:0008353; GO:0004693; GO:0070816; GO:0008024; GO:0034243; GO:0006360 O74627; Q9P6Q6 ATP binding; P-TEFb-cap methyltransferase complex; RNA polymerase II carboxy-terminal domain kinase activity; cyclin-dependent protein serine/threonine kinase activity; phosphorylation of RNA polymerase II C-terminal domain; positive transcription elongation factor complex b; regulation of transcription elongation from RNA polymerase II promoter; transcription from RNA polymerase I promoter IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Probable cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 9) cdk9 pi014 SPBC32H8.10 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR34902_c2_g2_i2 P57760 STK16_RAT 2.00E-48 GO:0005524; GO:0005798; GO:0001077; GO:0071560; GO:0016020; GO:0004715; GO:0048471; GO:0046777; GO:0004672; GO:0004674 ATP binding; Golgi-associated vesicle; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; cellular response to transforming growth factor beta stimulus; membrane; non-membrane spanning protein tyrosine kinase activity; perinuclear region of cytoplasm; protein autophosphorylation; protein kinase activity; protein serine/threonine kinase activity IPR011009; IPR000719; IPR008271; Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2) Stk16 Mpsk1 Tsf1 Rattus norvegicus (Rat) TR34902_c2_g2_i3 Q86HW6 Y6461_DICDI 9.00E-28 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR008271; Probable serine/threonine-protein kinase DDB_G0276461 (EC 2.7.11.1) DDB_G0276461 Dictyostelium discoideum (Slime mold) TR34903_c6_g2_i1 Q5BJR4 PRUN2_RAT 1.00E-73 GO:0005794; GO:0006915; GO:0005634 Golgi apparatus; apoptotic process; nucleus IPR022181; IPR001251; Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) Prune2 Bmcc1 Rattus norvegicus (Rat) TR34904_c0_g1_i1 Q6PIW4 FIGL1_HUMAN 3.00E-149 GO:0005524; GO:0046034; GO:0071479; GO:0005737; GO:0016787; GO:0000287; GO:0043066; GO:0000228; GO:0017111; GO:0001649; GO:0033687; GO:0051726; GO:0010569 ATP binding; ATP metabolic process; cellular response to ionizing radiation; cytoplasm; hydrolase activity; magnesium ion binding; negative regulation of apoptotic process; nuclear chromosome; nucleoside-triphosphatase activity; osteoblast differentiation; osteoblast proliferation; regulation of cell cycle; regulation of double-strand break repair via homologous recombination IPR003593; IPR003959; IPR003960; IPR027417; IPR015415; Fidgetin-like protein 1 (EC 3.6.4.-) FIGNL1 Homo sapiens (Human) TR34905_c0_g1_i1 Q7T0M6 AS1AB_XENLA 7.00E-78 GO:0006333; GO:0016568; GO:0005634; GO:0006355; GO:0006351 "chromatin assembly or disassembly; chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006818; Histone chaperone asf1a-B (Anti-silencing function protein 1 homolog A-B) asf1ab asf1a Xenopus laevis (African clawed frog) TR34908_c0_g1_i1 A2RU49 AGPD1_HUMAN 7.00E-49 GO:0005737; GO:0047992 cytoplasm; hydroxylysine kinase activity IPR002575; IPR011009; Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC 2.7.1.81) (Aminoglycoside phosphotransferase domain-containing protein 1) HYKK AGPHD1 Homo sapiens (Human) TR34908_c0_g1_i3 Q5U5V2 AGPD1_MOUSE 1.00E-45 GO:0005737; GO:0047992 cytoplasm; hydroxylysine kinase activity IPR002575; IPR011009; Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC 2.7.1.81) (Aminoglycoside phosphotransferase domain-containing protein 1) Hykk Agphd1 Mus musculus (Mouse) TR34908_c1_g1_i3 Q90W95 PTPS_POERE 2.00E-60 GO:0003874; GO:0046872; GO:0006729 6-pyruvoyltetrahydropterin synthase activity; metal ion binding; tetrahydrobiopterin biosynthetic process IPR007115; IPR022470; IPR022469; "Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3." 6-pyruvoyl tetrahydrobiopterin synthase (PTP synthase) (PTPS) (EC 4.2.3.12) pts Poecilia reticulata (Guppy) (Acanthophacelus reticulatus) TR34908_c1_g1_i4 P80081 PTPS_SALSA 2.00E-17 GO:0003874; GO:0046872; GO:0006729 6-pyruvoyltetrahydropterin synthase activity; metal ion binding; tetrahydrobiopterin biosynthetic process IPR007115; IPR022469; "Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3." 6-pyruvoyl tetrahydrobiopterin synthase (PTP synthase) (PTPS) (EC 4.2.3.12) (Fragments) pts Salmo salar (Atlantic salmon) TR34909_c2_g2_i2 Q25381 ACTM_LYTPI 9.00E-56 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; "Actin, muscle (LPM) (Fragment)" Lytechinus pictus (Painted sea urchin) TR34909_c2_g2_i3 P17126 ACT_HYDVU 6.00E-126 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin, non-muscle 6.2" Hydra vulgaris (Hydra) (Hydra attenuata) TR3491_c0_g1_i1 D8VNS8 FCNV2_CERRY 2.00E-51 GO:0005576 extracellular region IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ryncolin-2 Cerberus rynchops (Dog-faced water snake) TR34911_c1_g1_i1 Q96KC8 DNJC1_HUMAN 7.00E-53 GO:0001671; GO:0003677; GO:0003682; GO:0005783; GO:0005789; GO:0016021; GO:0045861; GO:0031965; GO:0006457; GO:0050708; GO:0006417 P01011 ATPase activator activity; DNA binding; chromatin binding; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; negative regulation of proteolysis; nuclear membrane; protein folding; regulation of protein secretion; regulation of translation IPR001623; IPR018253; IPR009057; IPR001005; IPR017884; DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1) DNAJC1 HTJ1 Homo sapiens (Human) TR34911_c1_g3_i1 P54103 DNJC2_MOUSE 6.00E-09 GO:0003677; GO:0006260; GO:0003682; GO:0016568; GO:0005829; GO:0042393; GO:2000279; GO:0031965; GO:0005634; GO:0045893; GO:0006351; GO:0043130 "DNA binding; DNA replication; chromatin binding; chromatin modification; cytosol; histone binding; negative regulation of DNA biosynthetic process; nuclear membrane; nucleus; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin binding" IPR001623; IPR018253; IPR009057; IPR017930; IPR001005; IPR017884; DnaJ homolog subfamily C member 2 (Mouse Id associate 1) (MIDA1) (Zuotin-related factor 1) Dnajc2 Mida1 Zrf1 Mus musculus (Mouse) TR34912_c0_g1_i1 Q9UKN7 MYO15_HUMAN 3.00E-84 GO:0005524; GO:0005737; GO:0042472; GO:0007626; GO:0003774; GO:0016459; GO:0007605; GO:0032420 ATP binding; cytoplasm; inner ear morphogenesis; locomotory behavior; motor activity; myosin complex; sensory perception of sound; stereocilium IPR019749; IPR019748; IPR000299; IPR000048; IPR001609; IPR000857; IPR027417; IPR011511; IPR001452; Unconventional myosin-XV (Unconventional myosin-15) MYO15A MYO15 Homo sapiens (Human) TR34912_c2_g1_i1 Q96JP2 MY15B_HUMAN 1.00E-14 GO:0005524; GO:0005737; GO:0003774; GO:0016459 ATP binding; cytoplasm; motor activity; myosin complex IPR000048; IPR001609; IPR000857; IPR027417; IPR011511; IPR001452; Unconventional myosin-XVB (Myosin XVBP) (Unconventional myosin-15B) MYO15B KIAA1783 MYO15BP Homo sapiens (Human) TR34915_c0_g1_i1 Q8BI21 RNF38_MOUSE 5.00E-47 GO:0008270 zinc ion binding IPR001841; IPR013083; RING finger protein 38 Rnf38 Mus musculus (Mouse) TR34915_c0_g2_i1 Q9H0F5 RNF38_HUMAN 1.00E-07 GO:0008270 zinc ion binding IPR001841; IPR013083; RING finger protein 38 RNF38 Homo sapiens (Human) TR34916_c2_g1_i2 Q7Z3D4 LYSM3_HUMAN 1.00E-19 GO:0016998; GO:0016021 cell wall macromolecule catabolic process; integral to membrane IPR018392; LysM and putative peptidoglycan-binding domain-containing protein 3 LYSMD3 Homo sapiens (Human) TR34917_c0_g1_i4 P40338 VHL_MOUSE 9.00E-13 GO:0030891; GO:0001525; GO:0043534; GO:0005829; GO:0030198; GO:0016020; GO:0005739; GO:0070244; GO:0000122; GO:0030182; GO:0005634; GO:0010498; GO:0051291; GO:0016567; GO:2001233; GO:0042069; GO:0045471; GO:0001666 VCB complex; angiogenesis; blood vessel endothelial cell migration; cytosol; extracellular matrix organization; membrane; mitochondrion; negative regulation of thymocyte apoptotic process; negative regulation of transcription from RNA polymerase II promoter; neuron differentiation; nucleus; proteasomal protein catabolic process; protein heterooligomerization; protein ubiquitination; regulation of apoptotic signaling pathway; regulation of catecholamine metabolic process; response to ethanol; response to hypoxia IPR002714; IPR024048; IPR024053; IPR022772; Protein modification; protein ubiquitination. Von Hippel-Lindau disease tumor suppressor (pVHL) Vhl Vhlh Mus musculus (Mouse) TR34918_c0_g1_i1 Q9CR27 CCD53_MOUSE 8.00E-52 GO:0071203 WASH complex IPR019309; WASH complex subunit CCDC53 (Coiled-coil domain-containing protein 53) Ccdc53 Mus musculus (Mouse) TR34918_c0_g1_i2 Q9Y3C0 CCD53_HUMAN 7.00E-50 GO:0071203 Q96EZ8; Q96AQ6 WASH complex IPR019309; WASH complex subunit CCDC53 (Coiled-coil domain-containing protein 53) CCDC53 AD-016 CGI-116 x0009 Homo sapiens (Human) TR34919_c0_g1_i1 Q90953 CSPG2_CHICK 4.00E-26 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Gallus gallus (Chicken) TR34919_c0_g1_i3 P86854 PLCL_MYTGA 5.00E-12 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR34922_c0_g1_i1 Q497V6 BAHD1_MOUSE 4.00E-20 GO:0003677; GO:0003682; GO:0005677; GO:0005694; GO:0031507; GO:0045892; GO:0006351 "DNA binding; chromatin binding; chromatin silencing complex; chromosome; heterochromatin assembly; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001025; Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) Bahd1 Gm117 Kiaa0945 Mus musculus (Mouse) TR34922_c3_g1_i1 Q8TBE0 BAHD1_HUMAN 2.00E-16 GO:0003677; GO:0003682; GO:0005677; GO:0005694; GO:0031507; GO:0045892; GO:0006351 "DNA binding; chromatin binding; chromatin silencing complex; chromosome; heterochromatin assembly; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001025; Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) BAHD1 KIAA0945 Homo sapiens (Human) TR34924_c0_g1_i1 Q25464 FP2_MYTGA 5.00E-55 GO:0005576 extracellular region IPR000742; IPR013032; IPR000152; Adhesive plaque matrix protein 2 (Foot protein 2) (MGFP-2) (MGFP2) FP2 Mytilus galloprovincialis (Mediterranean mussel) TR34924_c0_g1_i3 P10079 FBP1_STRPU 2.00E-58 GO:0032579; GO:0005509; GO:0016023; GO:0005615 apical lamina of hyaline layer; calcium ion binding; cytoplasmic membrane-bounded vesicle; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) TR34925_c2_g1_i1 P22031 LEG_ANTCR 2.00E-11 GO:0030246; GO:0005737 carbohydrate binding; cytoplasm IPR000922; D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL) Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR34925_c6_g2_i2 B4J780 LPHN_DROGR 1.00E-12 GO:0004930; GO:0030246; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; carbohydrate binding; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR000203; IPR000922; Latrophilin Cirl Cirl GH20083 Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) TR34926_c1_g1_i1 Q7ZYH1 SIN1_XENLA 2.00E-148 IPR008828; Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) mapkap1 sin1 Xenopus laevis (African clawed frog) TR34926_c1_g1_i2 Q7ZYH1 SIN1_XENLA 2.00E-148 IPR008828; Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) mapkap1 sin1 Xenopus laevis (African clawed frog) TR34928_c0_g1_i1 Q00719 MDMC_STRMY 5.00E-23 GO:0008171; GO:0017000; GO:0046872 O-methyltransferase activity; antibiotic biosynthetic process; metal ion binding IPR002935; O-methyltransferase MdmC (EC 2.1.1.-) mdmC Streptomyces mycarofaciens TR34928_c0_g1_i2 Q7F8T6 OMT17_ORYSJ 6.00E-24 GO:0008171; GO:0008757; GO:0046872 O-methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity; metal ion binding IPR002935; Tricin synthase 2 (EC 2.1.1.175) (Caffeoyl-CoA 3-O-methyltransferase ROMT17) ROMT-17 Os08g0498400 LOC_Os08g38910 OsJ_27815 P0026F07.26-1 P0026F07.26-2 Oryza sativa subsp. japonica (Rice) TR34928_c0_g1_i4 Q8H9B6 CAMT_SOLTU 1.00E-20 GO:0042409; GO:0009809; GO:0046872 caffeoyl-CoA O-methyltransferase activity; lignin biosynthetic process; metal ion binding IPR002935; Aromatic compound metabolism; phenylpropanoid biosynthesis. Caffeoyl-CoA O-methyltransferase (EC 2.1.1.104) (Trans-caffeoyl-CoA 3-O-methyltransferase) (CCoAMT) (CCoAOMT) CCOAOMT Solanum tuberosum (Potato) TR34928_c0_g1_i5 O81185 CAMT1_EUCGL 1.00E-23 GO:0042409; GO:0009809; GO:0046872 caffeoyl-CoA O-methyltransferase activity; lignin biosynthetic process; metal ion binding IPR002935; Aromatic compound metabolism; phenylpropanoid biosynthesis. Caffeoyl-CoA O-methyltransferase 1 (EC 2.1.1.104) (Trans-caffeoyl-CoA 3-O-methyltransferase 1) (CCoAMT-1) (CCoAOMT-1) CCOMT Eucalyptus globulus (Blue gum) TR34928_c0_g1_i6 Q86IC8 CAMT2_DICDI 2.00E-22 GO:0042409; GO:0046872; GO:0045335; GO:0009617 caffeoyl-CoA O-methyltransferase activity; metal ion binding; phagocytic vesicle; response to bacterium IPR002935; Probable caffeoyl-CoA O-methyltransferase 2 (EC 2.1.1.104) (O-methyltransferase 6) omt6 DDB_G0275501 Dictyostelium discoideum (Slime mold) TR34930_c3_g1_i4 Q29116 TENA_PIG 8.00E-53 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (P230) (Tenascin-C) (TN-C) TNC HXB Sus scrofa (Pig) TR34930_c3_g2_i1 Q95LU3 FBCD1_MACFA 6.00E-65 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR34930_c3_g4_i2 Q95LU3 FBCD1_MACFA 3.00E-18 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR34934_c1_g1_i1 Q9NFP5 SH3BG_DROME 3.00E-23 IPR006993; IPR012336; SH3 domain-binding glutamic acid-rich protein homolog (SH3BGR protein) Sh3beta SH3BGR CG8582 Drosophila melanogaster (Fruit fly) TR34934_c1_g1_i6 P55822 SH3BG_HUMAN 3.00E-23 GO:0005070; GO:0005829; GO:0006461 SH3/SH2 adaptor activity; cytosol; protein complex assembly IPR006993; IPR012336; SH3 domain-binding glutamic acid-rich protein (SH3BGR protein) (21-glutamic acid-rich protein) (21-GARP) SH3BGR Homo sapiens (Human) TR34934_c1_g1_i8 Q9NFP5 SH3BG_DROME 1.00E-24 IPR006993; IPR012336; SH3 domain-binding glutamic acid-rich protein homolog (SH3BGR protein) Sh3beta SH3BGR CG8582 Drosophila melanogaster (Fruit fly) TR34934_c1_g1_i9 Q58DU7 SH3L1_BOVIN 2.00E-22 IPR006993; IPR012336; SH3 domain-binding glutamic acid-rich-like protein SH3BGRL Bos taurus (Bovine) TR34935_c1_g1_i2 Q58909 Y1514_METJA 1.00E-13 GO:0016746 "transferase activity, transferring acyl groups" IPR009288; IPR013024; Putative gamma-glutamylcyclotransferase MJ1514 (EC 2.3.2.-) MJ1514 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR34935_c1_g2_i1 Q9W0Y2 YS11_DROME 2.00E-38 GO:0016746 "transferase activity, transferring acyl groups" IPR009288; IPR013024; Putative gamma-glutamylcyclotransferase CG2811 (EC 2.3.2.-) CG2811 Drosophila melanogaster (Fruit fly) TR34939_c0_g1_i1 P27214 ANX11_BOVIN 1.00E-90 GO:0044548; GO:0005509; GO:0005544; GO:0007109; GO:0042470; GO:0030496; GO:0005635; GO:0005654; GO:0005819 "S100 protein binding; calcium ion binding; calcium-dependent phospholipid binding; cytokinesis, completion of separation; melanosome; midbody; nuclear envelope; nucleoplasm; spindle" IPR001464; IPR018502; IPR018252; IPR008157; Annexin A11 (Annexin XI) (Annexin-11) (Calcyclin-associated annexin-50) (CAP-50) ANXA11 ANX11 Bos taurus (Bovine) TR34939_c0_g1_i3 P22464 ANXB9_DROME 4.00E-87 GO:0003779; GO:0061467; GO:0005509; GO:0005544; GO:0005938; GO:0012505; GO:0030011; GO:0010797; GO:0048190 actin binding; basolateral protein localization; calcium ion binding; calcium-dependent phospholipid binding; cell cortex; endomembrane system; maintenance of cell polarity; regulation of multivesicular body size involved in endosome transport; wing disc dorsal/ventral pattern formation IPR001464; IPR018502; IPR018252; Annexin-B9 (Annexin IX) (Annexin-9) AnnIX AnxB9 CG5730 Drosophila melanogaster (Fruit fly) TR34940_c2_g1_i2 O01393 UNC9_CAEEL 4.00E-43 GO:0005921; GO:0055077; GO:0016021; GO:0034220; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transmembrane transport; plasma membrane IPR000990; Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans TR34940_c2_g2_i2 Q9U3N4 INX6_CAEEL 8.00E-13 GO:0005921; GO:0055077; GO:0016021; GO:0006811; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transport; plasma membrane IPR000990; Innexin-6 (Protein opu-6) inx-6 opu-6 C36H8.2 Caenorhabditis elegans TR34941_c3_g1_i2 Q4QQT0 RUSD4_RAT 3.00E-58 GO:0003723; GO:0005739; GO:0009982; GO:0001522 RNA binding; mitochondrion; pseudouridine synthase activity; pseudouridine synthesis IPR020103; IPR006224; IPR006145; RNA pseudouridylate synthase domain-containing protein 4 Rpusd4 Rattus norvegicus (Rat) TR34941_c3_g1_i3 O66114 Y505_ZYMMO 4.00E-23 GO:0003723; GO:0009982; GO:0001522 RNA binding; pseudouridine synthase activity; pseudouridine synthesis IPR020103; IPR006224; IPR006145; Uncharacterized RNA pseudouridine synthase ZMO0505 (EC 5.4.99.-) (RNA pseudouridylate synthase) (RNA-uridine isomerase) ZMO0505 Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) TR34943_c3_g1_i1 O02739 SPB6_BOVIN 1.00E-58 GO:0005737; GO:0005615; GO:0030162; GO:0004867 cytoplasm; extracellular space; regulation of proteolysis; serine-type endopeptidase inhibitor activity IPR023795; IPR023796; IPR000215; Serpin B6 (Proteinase inhibitor 6) (Serine proteinase inhibitor B-43) SERPINB6 Bos taurus (Bovine) TR34943_c4_g1_i1 A2AQ25 SKT_MOUSE 2.00E-34 GO:0005737; GO:0048706 cytoplasm; embryonic skeletal system development IPR026725; Sickle tail protein (Enhancer trap locus 4) Skt Etl4 Kiaa1217 Mus musculus (Mouse) TR34943_c6_g4_i1 Q7PQ25 CCDCX_ANOGA 3.00E-39 IPR022782; Coiled-coil domain-containing protein AGAP005037 AGAP005037 Anopheles gambiae (African malaria mosquito) TR34943_c6_g4_i2 Q5T5P2 SKT_HUMAN 2.00E-15 GO:0005737; GO:0048706 cytoplasm; embryonic skeletal system development IPR026725; Sickle tail protein homolog KIAA1217 SKT Homo sapiens (Human) TR34944_c0_g1_i1 Q9D1M0 SEC13_MOUSE 1.00E-55 GO:0012507; GO:0006888; GO:0005783; GO:0005789; GO:0000776; GO:0051028; GO:0031080; GO:0015031 ER to Golgi transport vesicle membrane; ER to Golgi vesicle-mediated transport; endoplasmic reticulum; endoplasmic reticulum membrane; kinetochore; mRNA transport; nuclear pore outer ring; protein transport IPR015943; IPR001680; IPR017986; Protein SEC13 homolog (SEC13-like protein 1) (SEC13-related protein) Sec13 Sec13l1 Mus musculus (Mouse) TR34944_c0_g3_i1 O94319 SEC13_SCHPO 4.00E-45 GO:0030127; GO:0006888; GO:0000917; GO:0005829; GO:0005789; GO:0006886; GO:0051028; GO:0005643; GO:0006999; GO:0005634; GO:0005886 COPII vesicle coat; ER to Golgi vesicle-mediated transport; barrier septum assembly; cytosol; endoplasmic reticulum membrane; intracellular protein transport; mRNA transport; nuclear pore; nuclear pore organization; nucleus; plasma membrane IPR015943; IPR001680; IPR017986; Protein transport protein sec13 sec13 SPBC215.15 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR34946_c0_g1_i1 Q8VD66 ABHD4_MOUSE 8.00E-95 GO:0016787; GO:0016042 hydrolase activity; lipid catabolic process IPR000073; Abhydrolase domain-containing protein 4 (EC 3.1.1.-) (Alpha/beta-hydrolase 4) (Lyso-N-acylphosphatidylethanolamine lipase) Abhd4 Mus musculus (Mouse) TR34947_c0_g1_i2 O89114 DNJB5_MOUSE 1.00E-13 GO:0005829; GO:0000122; GO:0005634; GO:0006457; GO:0006986; GO:0051082 cytosol; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein folding; response to unfolded protein; unfolded protein binding IPR002939; IPR001623; IPR018253; IPR008971; DnaJ homolog subfamily B member 5 (Heat shock protein Hsp40-3) (Heat shock protein cognate 40) (Hsc40) Dnajb5 Hsc40 Mus musculus (Mouse) TR34952_c0_g2_i1 A4FLW9 RHMD_SACEN 2.00E-124 GO:0050032; GO:0009063; GO:0000287 L-rhamnonate dehydratase activity; cellular amino acid catabolic process; magnesium ion binding IPR023444; IPR018110; IPR013342; IPR013341; IPR001354; L-rhamnonate dehydratase (RhamD) (EC 4.2.1.90) rhmD SACE_5860 Saccharopolyspora erythraea (strain NRRL 23338) TR34953_c0_g1_i1 Q9Y2X7 GIT1_HUMAN 6.00E-127 GO:0008060; GO:0005737; GO:0005925; GO:0043547; GO:0032312; GO:0008277; GO:0008270 P25098; Q14155; Q99728; Q12873; P42858; Q9P2H0; Q5T3J3; Q13153; P49024 ARF GTPase activator activity; cytoplasm; focal adhesion; positive regulation of GTPase activity; regulation of ARF GTPase activity; regulation of G-protein coupled receptor protein signaling pathway; zinc ion binding IPR002110; IPR020683; IPR001164; IPR022018; IPR013724; ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) GIT1 Homo sapiens (Human) TR34953_c0_g2_i1 Q5W7F2 AGD3_ARATH 2.00E-24 GO:0008060; GO:0005829; GO:0006897; GO:0009965; GO:0010087; GO:0035091; GO:0005886; GO:0032312; GO:0009733; GO:0030140; GO:0010051; GO:0008270 P42697 ARF GTPase activator activity; cytosol; endocytosis; leaf morphogenesis; phloem or xylem histogenesis; phosphatidylinositol binding; plasma membrane; regulation of ARF GTPase activity; response to auxin stimulus; trans-Golgi network transport vesicle; xylem and phloem pattern formation; zinc ion binding IPR027267; IPR002110; IPR020683; IPR001164; IPR004148; IPR011993; IPR001849; ADP-ribosylation factor GTPase-activating protein AGD3 (ARF GAP AGD3) (Protein ARF-GAP DOMAIN 3) (AtAGD3) (Protein SCARFACE) (Protein VASCULAR NETWORK 3) AGD3 SFC VAN3 At5g13300 T31B5.120 Arabidopsis thaliana (Mouse-ear cress) TR34954_c3_g3_i1 Q6P135 TMUB1_DANRE 1.00E-28 GO:0005737; GO:0016021; GO:0005634 cytoplasm; integral to membrane; nucleus IPR000626; Transmembrane and ubiquitin-like domain-containing protein 1 tmub1 zgc:77146 Danio rerio (Zebrafish) (Brachydanio rerio) TR34954_c3_g3_i3 Q6P135 TMUB1_DANRE 1.00E-28 GO:0005737; GO:0016021; GO:0005634 cytoplasm; integral to membrane; nucleus IPR000626; Transmembrane and ubiquitin-like domain-containing protein 1 tmub1 zgc:77146 Danio rerio (Zebrafish) (Brachydanio rerio) TR34959_c2_g2_i1 Q6GMF8 RHDF1_DANRE 1.00E-45 GO:0000139; GO:0016477; GO:0008283; GO:0005789; GO:0016021; GO:0050709; GO:0015031; GO:0006508; GO:0042058; GO:0061136; GO:0004252 Golgi membrane; cell migration; cell proliferation; endoplasmic reticulum membrane; integral to membrane; negative regulation of protein secretion; protein transport; proteolysis; regulation of epidermal growth factor receptor signaling pathway; regulation of proteasomal protein catabolic process; serine-type endopeptidase activity IPR002610; IPR022764; IPR022241; Inactive rhomboid protein 1 (iRhom1) (Rhomboid family member 1) rhbdf1 zgc:91984 Danio rerio (Zebrafish) (Brachydanio rerio) TR34962_c1_g1_i2 Q655R6 MOCOS_ORYSJ 3.00E-15 GO:0006777; GO:0030151; GO:0030170; GO:0016740 Mo-molybdopterin cofactor biosynthetic process; molybdenum ion binding; pyridoxal phosphate binding; transferase activity IPR000192; IPR005302; IPR005303; IPR015424; IPR015421; IPR015422; IPR011037; Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (EC 2.8.1.9) (Molybdenum cofactor sulfurase-like protein 3) (Molybdenum cofactor sulfurtransferase) MCSU3 Os06g0670000 LOC_Os06g45860 P0686E06.35 Oryza sativa subsp. japonica (Rice) TR34962_c1_g1_i3 Q96EN8 MOCOS_HUMAN 5.00E-21 GO:0006777; GO:0008265; GO:0005829; GO:0030151; GO:0032324; GO:0030170; GO:0016740; GO:0006767 Mo-molybdopterin cofactor biosynthetic process; Mo-molybdopterin cofactor sulfurase activity; cytosol; molybdenum ion binding; molybdopterin cofactor biosynthetic process; pyridoxal phosphate binding; transferase activity; water-soluble vitamin metabolic process IPR000192; IPR005302; IPR005303; IPR015424; IPR015421; IPR015422; IPR011037; Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (hMCS) (EC 2.8.1.9) (Molybdenum cofactor sulfurtransferase) MOCOS Homo sapiens (Human) TR34962_c1_g1_i4 Q1LZH1 MOSC2_BOVIN 2.00E-67 GO:0005741; GO:0030151; GO:0043546; GO:0042126; GO:0008940; GO:0005777; GO:0030170 mitochondrial outer membrane; molybdenum ion binding; molybdopterin cofactor binding; nitrate metabolic process; nitrate reductase activity; peroxisome; pyridoxal phosphate binding IPR005302; IPR005303; IPR011037; "MOSC domain-containing protein 2, mitochondrial (EC 1.-.-.-) (Mitochondrial amidoxime reducing component 2) (mARC2)" MARC2 MOSC2 Bos taurus (Bovine) TR34963_c1_g1_i2 Q5ZJU0 MOT9_CHICK 1.00E-46 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 MCT9 RCJMB04_15m4 Gallus gallus (Chicken) TR34964_c0_g2_i1 P10394 POL4_DROME 2.00E-64 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR34964_c1_g1_i1 Q09575 YRD6_CAEEL 4.00E-22 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR34965_c1_g1_i2 Q9SFU0 SC24A_ARATH 5.00E-130 GO:0030127; GO:0080119; GO:0006888; GO:0000139; GO:0005789; GO:0033116; GO:0006886; GO:0008270 COPII vesicle coat; ER body organization; ER to Golgi vesicle-mediated transport; Golgi membrane; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; intracellular protein transport; zinc ion binding IPR007123; IPR006900; IPR006896; IPR012990; IPR002035; IPR006895; Protein transport protein Sec24-like At3g07100 At3g07100 T1B9.25 Arabidopsis thaliana (Mouse-ear cress) TR34965_c1_g1_i3 P53992 SC24C_HUMAN 0 GO:0030127; GO:0048208; GO:0000139; GO:0019886; GO:0002474; GO:0005829; GO:0005789; GO:0006886; GO:0005634; GO:0048471; GO:0043687; GO:0018279; GO:0044281; GO:0008270 Q15436 COPII vesicle coat; COPII vesicle coating; Golgi membrane; antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; cytosol; endoplasmic reticulum membrane; intracellular protein transport; nucleus; perinuclear region of cytoplasm; post-translational protein modification; protein N-linked glycosylation via asparagine; small molecule metabolic process; zinc ion binding IPR007123; IPR006900; IPR006896; IPR012990; IPR002035; IPR006895; Protein transport protein Sec24C (SEC24-related protein C) SEC24C KIAA0079 Homo sapiens (Human) TR34966_c0_g1_i1 P51892 DNLI1_XENLA 0 GO:0005524; GO:0003677; GO:0003910; GO:0051103; GO:0006310; GO:0006260; GO:0007049; GO:0051301; GO:0046872; GO:0005634 ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligation involved in DNA repair; DNA recombination; DNA replication; cell cycle; cell division; metal ion binding; nucleus IPR000977; IPR012309; IPR012310; IPR016059; IPR012308; IPR012340; DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) lig1 Xenopus laevis (African clawed frog) TR34966_c1_g1_i1 Q18HT7 DNLI1_HALWD 5.00E-15 GO:0005524; GO:0003677; GO:0003910; GO:0051103; GO:0006310; GO:0006260; GO:0007049; GO:0051301; GO:0046872 ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligation involved in DNA repair; DNA recombination; DNA replication; cell cycle; cell division; metal ion binding IPR022865; IPR000977; IPR012309; IPR012310; IPR016059; IPR012308; IPR012340; DNA ligase 1 (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP] 1) lig1 HQ_2327A Haloquadratum walsbyi (strain DSM 16790 / HBSQ001) TR34968_c1_g2_i2 Q5FWF7 FBX48_HUMAN 4.00E-19 IPR001810; F-box only protein 48 FBXO48 FBX48 Homo sapiens (Human) TR34969_c3_g1_i1 O75197 LRP5_HUMAN 3.00E-22 GO:0044332; GO:0042813; GO:0017147; GO:0060612; GO:0009952; GO:0048539; GO:0060349; GO:0046849; GO:0060444; GO:0060070; GO:0042632; GO:0015026; GO:0048596; GO:0030326; GO:0060059; GO:0006897; GO:0005783; GO:0001702; GO:0006007; GO:0016021; GO:0045668; GO:0071901; GO:0002076; GO:0005886; GO:0045600; GO:0002053; GO:0045840; GO:0045944; GO:0043235; GO:0008217; GO:0060828; GO:0061178; GO:0061304 Q6IMN6 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt-activated receptor activity; Wnt-protein binding; adipose tissue development; anterior/posterior pattern specification; bone marrow development; bone morphogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway; cholesterol homeostasis; coreceptor activity; embryonic camera-type eye morphogenesis; embryonic limb morphogenesis; embryonic retina morphogenesis in camera-type eye; endocytosis; endoplasmic reticulum; gastrulation with mouth forming second; glucose catabolic process; integral to membrane; negative regulation of osteoblast differentiation; negative regulation of protein serine/threonine kinase activity; osteoblast development; plasma membrane; positive regulation of fat cell differentiation; positive regulation of mesenchymal cell proliferation; positive regulation of mitosis; positive regulation of transcription from RNA polymerase II promoter; receptor complex; regulation of blood pressure; regulation of canonical Wnt receptor signaling pathway; regulation of insulin secretion involved in cellular response to glucose stimulus; retinal blood vessel morphogenesis IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 5 (LRP-5) LRP5 LR3 LRP7 Homo sapiens (Human) TR34969_c3_g1_i2 O88572 LRP6_MOUSE 3.00E-25 GO:0044332; GO:0021874; GO:0090244; GO:0042813; GO:0090245; GO:0046849; GO:0060444; GO:0061310; GO:0061324; GO:0005901; GO:0042074; GO:0009986; GO:0071397; GO:0021587; GO:0021795; GO:0060026; GO:0015026; GO:0071936; GO:0031410; GO:0071542; GO:0005769; GO:0048596; GO:0042733; GO:0035115; GO:0035116; GO:0009880; GO:0060059; GO:0005783; GO:0035261; GO:0060325; GO:0021861; GO:0021943; GO:0001947; GO:0016021; GO:0019210; GO:0005041; GO:0060596; GO:0030901; GO:0030917; GO:0050680; GO:0045599; GO:2000151; GO:2000162; GO:2000168; GO:2000164; GO:2000166; GO:2000149; GO:0071901; GO:0034392; GO:0014029; GO:0001843; GO:0043025; GO:0042475; GO:0060021; GO:0003344; GO:2000055; GO:0043065; GO:0045780; GO:0090263; GO:0045787; GO:0002053; GO:0045778; GO:0051091; GO:0045944; GO:0036342; GO:0090009; GO:0043235; GO:0090118; GO:0060284; GO:0051593; GO:0048705; GO:0045202; GO:0007268; GO:0021794; GO:0019534; GO:0060535 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt receptor signaling pathway involved in forebrain neuroblast division; Wnt receptor signaling pathway involved in somitogenesis; Wnt-activated receptor activity; axis elongation involved in somitogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development; canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; caveola; cell migration involved in gastrulation; cell surface; cellular response to cholesterol; cerebellum morphogenesis; cerebral cortex cell migration; convergent extension; coreceptor activity; coreceptor activity involved in Wnt receptor signaling pathway; cytoplasmic vesicle; dopaminergic neuron differentiation; early endosome; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic pattern specification; embryonic retina morphogenesis in camera-type eye; endoplasmic reticulum; external genitalia morphogenesis; face morphogenesis; forebrain radial glial cell differentiation; formation of radial glial scaffolds; heart looping; integral to membrane; kinase inhibitor activity; low-density lipoprotein receptor activity; mammary placode formation; midbrain development; midbrain-hindbrain boundary development; negative regulation of epithelial cell proliferation; negative regulation of fat cell differentiation; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis; negative regulation of planar cell polarity pathway involved in neural tube closure; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest formation; neural tube closure; neuronal cell body; odontogenesis of dentin-containing tooth; palate development; pericardium morphogenesis; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell cycle; positive regulation of mesenchymal cell proliferation; positive regulation of ossification; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; post-anal tail morphogenesis; primitive streak formation; receptor complex; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport; regulation of cell development; response to folic acid; skeletal system morphogenesis; synapse; synaptic transmission; thalamus development; toxin transporter activity; trachea cartilage morphogenesis IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 6 (LRP-6) Lrp6 Mus musculus (Mouse) TR34969_c3_g1_i3 O75096 LRP4_HUMAN 3.00E-19 GO:0016055; GO:0005509; GO:0030154; GO:0009953; GO:0042733; GO:0006897; GO:0030198; GO:0001942; GO:0016021; GO:0001822; GO:0090090; GO:0030279; GO:0042475; GO:0005886; GO:0009954; GO:0043113; GO:0001932; GO:0051124 Wnt receptor signaling pathway; calcium ion binding; cell differentiation; dorsal/ventral pattern formation; embryonic digit morphogenesis; endocytosis; extracellular matrix organization; hair follicle development; integral to membrane; kidney development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of ossification; odontogenesis of dentin-containing tooth; plasma membrane; proximal/distal pattern formation; receptor clustering; regulation of protein phosphorylation; synaptic growth at neuromuscular junction IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) TR34969_c3_g1_i5 Q9Y5Y6 ST14_HUMAN 3.00E-20 GO:0005576; GO:0019897; GO:0005887; GO:0006508; GO:0004252; GO:0008236 extracellular region; extrinsic to plasma membrane; integral to plasma membrane; proteolysis; serine-type endopeptidase activity; serine-type peptidase activity IPR000859; IPR023415; IPR002172; IPR001254; IPR018114; IPR017051; IPR000082; IPR009003; Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein) ST14 PRSS14 SNC19 TADG15 Homo sapiens (Human) TR34969_c3_g1_i6 O88572 LRP6_MOUSE 1.00E-21 GO:0044332; GO:0021874; GO:0090244; GO:0042813; GO:0090245; GO:0046849; GO:0060444; GO:0061310; GO:0061324; GO:0005901; GO:0042074; GO:0009986; GO:0071397; GO:0021587; GO:0021795; GO:0060026; GO:0015026; GO:0071936; GO:0031410; GO:0071542; GO:0005769; GO:0048596; GO:0042733; GO:0035115; GO:0035116; GO:0009880; GO:0060059; GO:0005783; GO:0035261; GO:0060325; GO:0021861; GO:0021943; GO:0001947; GO:0016021; GO:0019210; GO:0005041; GO:0060596; GO:0030901; GO:0030917; GO:0050680; GO:0045599; GO:2000151; GO:2000162; GO:2000168; GO:2000164; GO:2000166; GO:2000149; GO:0071901; GO:0034392; GO:0014029; GO:0001843; GO:0043025; GO:0042475; GO:0060021; GO:0003344; GO:2000055; GO:0043065; GO:0045780; GO:0090263; GO:0045787; GO:0002053; GO:0045778; GO:0051091; GO:0045944; GO:0036342; GO:0090009; GO:0043235; GO:0090118; GO:0060284; GO:0051593; GO:0048705; GO:0045202; GO:0007268; GO:0021794; GO:0019534; GO:0060535 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt receptor signaling pathway involved in forebrain neuroblast division; Wnt receptor signaling pathway involved in somitogenesis; Wnt-activated receptor activity; axis elongation involved in somitogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development; canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; caveola; cell migration involved in gastrulation; cell surface; cellular response to cholesterol; cerebellum morphogenesis; cerebral cortex cell migration; convergent extension; coreceptor activity; coreceptor activity involved in Wnt receptor signaling pathway; cytoplasmic vesicle; dopaminergic neuron differentiation; early endosome; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic pattern specification; embryonic retina morphogenesis in camera-type eye; endoplasmic reticulum; external genitalia morphogenesis; face morphogenesis; forebrain radial glial cell differentiation; formation of radial glial scaffolds; heart looping; integral to membrane; kinase inhibitor activity; low-density lipoprotein receptor activity; mammary placode formation; midbrain development; midbrain-hindbrain boundary development; negative regulation of epithelial cell proliferation; negative regulation of fat cell differentiation; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis; negative regulation of planar cell polarity pathway involved in neural tube closure; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest formation; neural tube closure; neuronal cell body; odontogenesis of dentin-containing tooth; palate development; pericardium morphogenesis; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell cycle; positive regulation of mesenchymal cell proliferation; positive regulation of ossification; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; post-anal tail morphogenesis; primitive streak formation; receptor complex; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport; regulation of cell development; response to folic acid; skeletal system morphogenesis; synapse; synaptic transmission; thalamus development; toxin transporter activity; trachea cartilage morphogenesis IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 6 (LRP-6) Lrp6 Mus musculus (Mouse) TR34969_c3_g1_i7 O75197 LRP5_HUMAN 4.00E-22 GO:0044332; GO:0042813; GO:0017147; GO:0060612; GO:0009952; GO:0048539; GO:0060349; GO:0046849; GO:0060444; GO:0060070; GO:0042632; GO:0015026; GO:0048596; GO:0030326; GO:0060059; GO:0006897; GO:0005783; GO:0001702; GO:0006007; GO:0016021; GO:0045668; GO:0071901; GO:0002076; GO:0005886; GO:0045600; GO:0002053; GO:0045840; GO:0045944; GO:0043235; GO:0008217; GO:0060828; GO:0061178; GO:0061304 Q6IMN6 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt-activated receptor activity; Wnt-protein binding; adipose tissue development; anterior/posterior pattern specification; bone marrow development; bone morphogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway; cholesterol homeostasis; coreceptor activity; embryonic camera-type eye morphogenesis; embryonic limb morphogenesis; embryonic retina morphogenesis in camera-type eye; endocytosis; endoplasmic reticulum; gastrulation with mouth forming second; glucose catabolic process; integral to membrane; negative regulation of osteoblast differentiation; negative regulation of protein serine/threonine kinase activity; osteoblast development; plasma membrane; positive regulation of fat cell differentiation; positive regulation of mesenchymal cell proliferation; positive regulation of mitosis; positive regulation of transcription from RNA polymerase II promoter; receptor complex; regulation of blood pressure; regulation of canonical Wnt receptor signaling pathway; regulation of insulin secretion involved in cellular response to glucose stimulus; retinal blood vessel morphogenesis IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 5 (LRP-5) LRP5 LR3 LRP7 Homo sapiens (Human) TR34969_c3_g1_i8 P35950 LDLR_CRIGR 4.00E-07 GO:0005794; GO:0005509; GO:0009986; GO:0008203; GO:0005905; GO:0005769; GO:0006897; GO:0016021; GO:0005770; GO:0006869; GO:0034362; GO:0005764; GO:0005886 Golgi apparatus; calcium ion binding; cell surface; cholesterol metabolic process; coated pit; early endosome; endocytosis; integral to membrane; late endosome; lipid transport; low-density lipoprotein particle; lysosome; plasma membrane IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor (LDL receptor) LDLR LDLA I79_005860 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR3497_c0_g3_i1 Q80V63 PRDM4_MOUSE 6.00E-08 GO:0003677; GO:0046872; GO:0008168; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; methyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001214; IPR007087; IPR015880; IPR013087; IPR017124; PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4) Prdm4 Mus musculus (Mouse) TR34972_c0_g1_i1 Q00224 ATP6_MYTED 4.00E-62 GO:0015986; GO:0015078; GO:0016021; GO:0005743; GO:0045263 "ATP synthesis coupled proton transport; hydrogen ion transmembrane transporter activity; integral to membrane; mitochondrial inner membrane; proton-transporting ATP synthase complex, coupling factor F(o)" IPR000568; ATP synthase subunit a (F-ATPase protein 6) ATP6 Mytilus edulis (Blue mussel) TR34973_c0_g1_i1 Q3UYG8 MACD2_MOUSE 6.00E-69 GO:0007420; GO:0016798; GO:0005634; GO:0051725; GO:0006974 "brain development; hydrolase activity, acting on glycosyl bonds; nucleus; protein de-ADP-ribosylation; response to DNA damage stimulus" IPR002589; O-acetyl-ADP-ribose deacetylase MACROD2 (EC 3.2.2.-) (EC 3.5.1.-) (MACRO domain-containing protein 2) ([Protein ADP-ribosylglutamate] hydrolase) Macrod2 Mus musculus (Mouse) TR34973_c0_g1_i4 Q9BQ69 MACD1_HUMAN 1.00E-62 GO:0019213; GO:0016798; GO:0005739; GO:0005634; GO:0051725; GO:0042278; GO:0006974 P03372 "deacetylase activity; hydrolase activity, acting on glycosyl bonds; mitochondrion; nucleus; protein de-ADP-ribosylation; purine nucleoside metabolic process; response to DNA damage stimulus" IPR002589; O-acetyl-ADP-ribose deacetylase MACROD1 (EC 3.2.2.-) (EC 3.5.1.-) (MACRO domain-containing protein 1) (Protein LRP16) ([Protein ADP-ribosylglutamate] hydrolase) MACROD1 LRP16 Homo sapiens (Human) TR34977_c3_g1_i1 Q9Z2X2 PSD10_MOUSE 9.00E-46 GO:0015629; GO:0006915; GO:0005737; GO:0007253; GO:0045111; GO:0043518; GO:0043409; GO:0032088; GO:0043066; GO:0090201; GO:0000122; GO:0005634; GO:0030307; GO:0045737; GO:0032436; GO:0031398; GO:0070682; GO:0008540 "actin cytoskeleton; apoptotic process; cytoplasm; cytoplasmic sequestering of NF-kappaB; intermediate filament cytoskeleton; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of MAPK cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of apoptotic process; negative regulation of release of cytochrome c from mitochondria; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of cell growth; positive regulation of cyclin-dependent protein kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; proteasome regulatory particle assembly; proteasome regulatory particle, base subcomplex" IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) Psmd10 Mus musculus (Mouse) TR34977_c3_g2_i1 Q9J504 V231_FOWPN 1.00E-11 IPR002110; IPR020683; Putative ankyrin repeat protein FPV231 FPV231 Fowlpox virus (strain NVSL) (FPV) TR34977_c5_g1_i1 O97902 ASAP1_BOVIN 0 GO:0008060; GO:0060271; GO:0005737; GO:0016020; GO:0005543; GO:0043547; GO:0032312; GO:0008270 ARF GTPase activator activity; cilium morphogenesis; cytoplasm; membrane; phospholipid binding; positive regulation of GTPase activity; regulation of ARF GTPase activity; zinc ion binding IPR027267; IPR002110; IPR020683; IPR001164; IPR011993; IPR001849; IPR001452; "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)" ASAP1 DDEF1 Bos taurus (Bovine) TR34977_c5_g4_i3 Q9QWY8 ASAP1_MOUSE 1.00E-16 GO:0008060; GO:0060271; GO:0005737; GO:0016020; GO:0005543; GO:0043547; GO:0032312; GO:0008270 P00523 ARF GTPase activator activity; cilium morphogenesis; cytoplasm; membrane; phospholipid binding; positive regulation of GTPase activity; regulation of ARF GTPase activity; zinc ion binding IPR027267; IPR002110; IPR020683; IPR001164; IPR011993; IPR001849; IPR001452; "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)" Asap1 Ddef1 Kiaa1249 Shag1 Mus musculus (Mouse) TR34977_c6_g1_i1 Q7ZU29 NUP93_DANRE 0 GO:0051028; GO:0031965; GO:0034399; GO:0005643; GO:0051292; GO:0015031; GO:0017056 mRNA transport; nuclear membrane; nuclear periphery; nuclear pore; nuclear pore complex assembly; protein transport; structural constituent of nuclear pore IPR007231; Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Dead eye protein) (Nucleoporin Nup93) dye Danio rerio (Zebrafish) (Brachydanio rerio) TR34978_c1_g1_i2 Q9QZ85 IIGP1_MOUSE 1.00E-23 GO:0019003; GO:0005525; GO:0003924; GO:0032580; GO:0035458; GO:0019221; GO:0050829; GO:0042832; GO:0005789; GO:0042802; GO:0045087; GO:0031965; GO:0010506; GO:0020005 GDP binding; GTP binding; GTPase activity; Golgi cisterna membrane; cellular response to interferon-beta; cytokine-mediated signaling pathway; defense response to Gram-negative bacterium; defense response to protozoan; endoplasmic reticulum membrane; identical protein binding; innate immune response; nuclear membrane; regulation of autophagy; symbiont-containing vacuole membrane IPR007743; IPR027417; Interferon-inducible GTPase 1 (EC 3.6.5.-) Iigp1 Irga6 Mus musculus (Mouse) TR34980_c7_g2_i1 P49870 HR38_BOMMO 7.00E-56 GO:0030522; GO:0004879; GO:0005634; GO:0043565; GO:0003707; GO:0008270 intracellular receptor signaling pathway; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleus; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding IPR003070; IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Probable nuclear hormone receptor HR38 (bHR38) (Nuclear receptor subfamily 4 group A member 4) (Fragment) HR38 NR4A4 Bombyx mori (Silk moth) TR34981_c0_g2_i1 Q0VC33 TSN11_BOVIN 1.00E-40 GO:0016021 integral to membrane IPR000301; IPR018499; IPR008952; Tetraspanin-11 (Tspan-11) TSPAN11 Bos taurus (Bovine) TR34981_c0_g2_i2 P61171 CD151_MACMU 5.00E-35 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; CD151 antigen (Platelet-endothelial tetraspan antigen 3) (PETA-3) (CD antigen CD151) CD151 Macaca mulatta (Rhesus macaque) TR34983_c0_g1_i3 Q6AYA6 CQ062_RAT 1.00E-24 GO:0016021 integral to membrane IPR027846; Uncharacterized protein C17orf62 homolog Rattus norvegicus (Rat) TR34984_c0_g1_i1 O70496 CLCN7_MOUSE 0 GO:0005524; GO:0015297; GO:0031410; GO:0016021; GO:0005765; GO:0009268; GO:0005247 Q8BGT0 ATP binding; antiporter activity; cytoplasmic vesicle; integral to membrane; lysosomal membrane; response to pH; voltage-gated chloride channel activity IPR000644; IPR014743; IPR001807; IPR002249; H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) Clcn7 Clc7 Mus musculus (Mouse) TR34984_c0_g1_i2 O70496 CLCN7_MOUSE 0 GO:0005524; GO:0015297; GO:0031410; GO:0016021; GO:0005765; GO:0009268; GO:0005247 Q8BGT0 ATP binding; antiporter activity; cytoplasmic vesicle; integral to membrane; lysosomal membrane; response to pH; voltage-gated chloride channel activity IPR000644; IPR014743; IPR001807; IPR002249; H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) Clcn7 Clc7 Mus musculus (Mouse) TR34986_c0_g1_i2 Q9Y3A2 UTP11_HUMAN 6.00E-41 GO:0005737; GO:0097194; GO:0005615; GO:0007399; GO:0048011; GO:0005730; GO:0005634; GO:2001272; GO:0006364; GO:0032040 cytoplasm; execution phase of apoptosis; extracellular space; nervous system development; neurotrophin TRK receptor signaling pathway; nucleolus; nucleus; positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; rRNA processing; small-subunit processome IPR007144; Probable U3 small nucleolar RNA-associated protein 11 (U3 snoRNA-associated protein 11) (UTP11-like protein) UTP11L CGI-94 HDCMB12P Homo sapiens (Human) TR34986_c0_g1_i3 Q9W3C0 UTP11_DROME 2.00E-24 GO:0022008; GO:0005730; GO:0006364; GO:0032040; GO:0006412 neurogenesis; nucleolus; rRNA processing; small-subunit processome; translation IPR007144; Probable U3 small nucleolar RNA-associated protein 11 (U3 snoRNA-associated protein 11) CG1789 Drosophila melanogaster (Fruit fly) TR34988_c6_g1_i1 Q9DAI6 F135B_MOUSE 1.00E-06 IPR022122; IPR007751; Protein FAM135B Fam135b Mus musculus (Mouse) TR34988_c9_g1_i1 Q5RA75 F135A_PONAB 6.00E-73 IPR022122; IPR007751; Protein FAM135A FAM135A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34989_c1_g1_i3 Q5R5X0 PININ_PONAB 5.00E-27 GO:0003677; GO:0008380; GO:0030057; GO:0006397; GO:0016607; GO:0006355; GO:0005681; GO:0006351 "DNA binding; RNA splicing; desmosome; mRNA processing; nuclear speck; regulation of transcription, DNA-dependent; spliceosomal complex; transcription, DNA-dependent" IPR006786; IPR006787; Pinin PNN Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34989_c1_g1_i6 Q5R5X0 PININ_PONAB 8.00E-27 GO:0003677; GO:0008380; GO:0030057; GO:0006397; GO:0016607; GO:0006355; GO:0005681; GO:0006351 "DNA binding; RNA splicing; desmosome; mRNA processing; nuclear speck; regulation of transcription, DNA-dependent; spliceosomal complex; transcription, DNA-dependent" IPR006786; IPR006787; Pinin PNN Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34993_c0_g1_i4 Q3SZB4 ACADM_BOVIN 0 GO:0003995; GO:0055007; GO:0019254; GO:0006635; GO:0033539; GO:0050660; GO:0005978; GO:0001889; GO:0051791; GO:0070991; GO:0005759; GO:0009791; GO:0006111; GO:0009409; GO:0042594 "acyl-CoA dehydrogenase activity; cardiac muscle cell differentiation; carnitine metabolic process, CoA-linked; fatty acid beta-oxidation; fatty acid beta-oxidation using acyl-CoA dehydrogenase; flavin adenine dinucleotide binding; glycogen biosynthetic process; liver development; medium-chain fatty acid metabolic process; medium-chain-acyl-CoA dehydrogenase activity; mitochondrial matrix; post-embryonic development; regulation of gluconeogenesis; response to cold; response to starvation" IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Lipid metabolism; mitochondrial fatty acid beta-oxidation. "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC 1.3.8.7)" ACADM Bos taurus (Bovine) TR34994_c4_g2_i2 Q8JHI3 AR13B_DANRE 9.00E-20 GO:0005525; GO:0005929; GO:0042384; GO:0007275; GO:0007264 GTP binding; cilium; cilium assembly; multicellular organismal development; small GTPase mediated signal transduction IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1) (Protein scorpion) arl13b arl2l1 Danio rerio (Zebrafish) (Brachydanio rerio) TR34996_c0_g2_i1 Q8SSS9 QKGA_DICDI 4.00E-06 GO:0005524; GO:0005525; GO:0005737; GO:0031158; GO:0008285; GO:0006997; GO:0004674; GO:0007264 ATP binding; GTP binding; cytoplasm; negative regulation of aggregate size involved in sorocarp development; negative regulation of cell proliferation; nucleus organization; protein serine/threonine kinase activity; small GTPase mediated signal transduction IPR011009; IPR001611; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR001245; Probable serine/threonine-protein kinase qkgA (EC 2.7.11.1) (Quick growth protein qkgA) (Ras of complex proteins and C-terminal of roc 2) qkgA-1 roco2-1 DDB_G0273259; qkgA-2 roco2-2 DDB_G0273635 Dictyostelium discoideum (Slime mold) TR34997_c1_g1_i1 Q07171 GELS_DROME 5.00E-69 GO:0003779; GO:0005884; GO:0030041; GO:0005829; GO:0005576; GO:0046872; GO:0006909 actin binding; actin filament; actin filament polymerization; cytosol; extracellular region; metal ion binding; phagocytosis IPR007123; IPR007122; Gelsolin Gel CG1106 Drosophila melanogaster (Fruit fly) TR34997_c1_g1_i3 O93510 GELS_CHICK 9.00E-61 GO:0051693; GO:0060271; GO:0005737; GO:0005856; GO:0005576; GO:0046872 actin filament capping; cilium morphogenesis; cytoplasm; cytoskeleton; extracellular region; metal ion binding IPR007123; IPR007122; Gelsolin (Actin-depolymerizing factor) (ADF) (Brevin) (Homogenin) GSN Gallus gallus (Chicken) TR34997_c1_g1_i4 Q8MPM1 GELS2_LUMTE 8.00E-142 GO:0051693; GO:0005737; GO:0005856 actin filament capping; cytoplasm; cytoskeleton IPR007123; IPR007122; Gelsolin-like protein 2 (Actin-modulator) (EWAM-P2) gelsolin Lumbricus terrestris (Common earthworm) TR34998_c0_g2_i1 Q5F477 CB043_CHICK 2.00E-62 IPR019363; UPF0554 protein C2orf43 homolog RCJMB04_2g19 Gallus gallus (Chicken) TR35001_c1_g1_i1 Q6ZVK1 T179A_HUMAN 1.00E-18 GO:0016021 integral to membrane Transmembrane protein 179 (Transmembrane protein 179A) TMEM179 C14orf90 TMEM179A Homo sapiens (Human) TR35001_c1_g1_i6 Q6ZVK1 T179A_HUMAN 2.00E-18 GO:0016021 integral to membrane Transmembrane protein 179 (Transmembrane protein 179A) TMEM179 C14orf90 TMEM179A Homo sapiens (Human) TR35002_c8_g4_i1 Q7QH62 MED4_ANOGA 9.00E-59 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR019258; Mediator of RNA polymerase II transcription subunit 4 (Mediator complex subunit 4) MED4 AGAP004063 Anopheles gambiae (African malaria mosquito) TR35005_c6_g1_i1 P21271 MYO5B_MOUSE 1.00E-64 GO:0005524; GO:0003774; GO:0016459; GO:0015031 ATP binding; motor activity; myosin complex; protein transport IPR018444; IPR002710; IPR000048; IPR001609; IPR027417; IPR016038; Unconventional myosin-Vb Myo5b Kiaa1119 Mus musculus (Mouse) TR35005_c6_g1_i2 Q02440 MYO5A_CHICK 5.00E-74 GO:0005524; GO:0000139; GO:0032869; GO:0031941; GO:0032593; GO:0060001; GO:0016459; GO:0072659; GO:0016192 P14649 ATP binding; Golgi membrane; cellular response to insulin stimulus; filamentous actin; insulin-responsive compartment; minus-end directed microfilament motor activity; myosin complex; protein localization to plasma membrane; vesicle-mediated transport IPR018444; IPR002710; IPR000048; IPR001609; IPR027417; "Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain p190) (Myosin-V)" MYO5A Gallus gallus (Chicken) TR35005_c6_g1_i3 Q02440 MYO5A_CHICK 1.00E-70 GO:0005524; GO:0000139; GO:0032869; GO:0031941; GO:0032593; GO:0060001; GO:0016459; GO:0072659; GO:0016192 P14649 ATP binding; Golgi membrane; cellular response to insulin stimulus; filamentous actin; insulin-responsive compartment; minus-end directed microfilament motor activity; myosin complex; protein localization to plasma membrane; vesicle-mediated transport IPR018444; IPR002710; IPR000048; IPR001609; IPR027417; "Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain p190) (Myosin-V)" MYO5A Gallus gallus (Chicken) TR35006_c1_g1_i1 Q3UPF5 ZCCHV_MOUSE 6.00E-07 GO:0017151; GO:0005794; GO:0003950; GO:0003723; GO:0071360; GO:0005737; GO:0051607; GO:0045087; GO:0046872; GO:0045071; GO:0005634; GO:0005886; GO:0032781; GO:0043123; GO:1900246; GO:0032727; GO:0032728; GO:0061014; GO:0032481; GO:0009615 DEAD/H-box RNA helicase binding; Golgi apparatus; NAD+ ADP-ribosyltransferase activity; RNA binding; cellular response to exogenous dsRNA; cytoplasm; defense response to virus; innate immune response; metal ion binding; negative regulation of viral genome replication; nucleus; plasma membrane; positive regulation of ATPase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of RIG-I signaling pathway; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of mRNA catabolic process; positive regulation of type I interferon production; response to virus IPR012317; IPR004170; IPR000571; Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) Zc3hav1 Mus musculus (Mouse) TR35006_c1_g3_i1 Q9H0J9 PAR12_HUMAN 6.00E-09 GO:0003950; GO:0046872; GO:0005634 NAD+ ADP-ribosyltransferase activity; metal ion binding; nucleus IPR012317; IPR004170; IPR000571; Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) TR35006_c1_g4_i1 Q8BZ20 PAR12_MOUSE 1.00E-70 GO:0003950; GO:0046872; GO:0005634 NAD+ ADP-ribosyltransferase activity; metal ion binding; nucleus IPR012317; IPR004170; IPR000571; Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) Parp12 Zc3hdc1 Mus musculus (Mouse) TR35011_c3_g1_i1 Q03042 KGP1_DROME 0 GO:0005524; GO:0030553; GO:0004692; GO:0007526 ATP binding; cGMP binding; cGMP-dependent protein kinase activity; larval somatic muscle development IPR000961; IPR016232; IPR002374; IPR018490; IPR018488; IPR000595; IPR011009; IPR000719; IPR017441; IPR014710; IPR002290; IPR008271; "cGMP-dependent protein kinase, isozyme 1 (cGK) (EC 2.7.11.12)" Pkg21D DG1 CG3324 Drosophila melanogaster (Fruit fly) TR35011_c3_g1_i2 Q03042 KGP1_DROME 0 GO:0005524; GO:0030553; GO:0004692; GO:0007526 ATP binding; cGMP binding; cGMP-dependent protein kinase activity; larval somatic muscle development IPR000961; IPR016232; IPR002374; IPR018490; IPR018488; IPR000595; IPR011009; IPR000719; IPR017441; IPR014710; IPR002290; IPR008271; "cGMP-dependent protein kinase, isozyme 1 (cGK) (EC 2.7.11.12)" Pkg21D DG1 CG3324 Drosophila melanogaster (Fruit fly) TR35012_c4_g2_i1 Q9EPL9 ACOX3_MOUSE 9.00E-83 GO:0003995; GO:0006635; GO:0033540; GO:0050660; GO:0005739; GO:0005782; GO:0016402 acyl-CoA dehydrogenase activity; fatty acid beta-oxidation; fatty acid beta-oxidation using acyl-CoA oxidase; flavin adenine dinucleotide binding; mitochondrion; peroxisomal matrix; pristanoyl-CoA oxidase activity IPR006091; IPR012258; IPR002655; IPR009075; IPR009100; Lipid metabolism; peroxisomal fatty acid beta-oxidation. Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase) Acox3 Mus musculus (Mouse) TR35012_c5_g1_i3 O15254 ACOX3_HUMAN 5.00E-52 GO:0003995; GO:0033540; GO:0050660; GO:0005739; GO:0005782; GO:0016402 acyl-CoA dehydrogenase activity; fatty acid beta-oxidation using acyl-CoA oxidase; flavin adenine dinucleotide binding; mitochondrion; peroxisomal matrix; pristanoyl-CoA oxidase activity IPR006091; IPR012258; IPR002655; IPR009075; IPR009100; Lipid metabolism; peroxisomal fatty acid beta-oxidation. Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase) ACOX3 BRCOX PRCOX Homo sapiens (Human) TR35014_c0_g3_i1 Q68FG0 ZC4H2_MOUSE 3.00E-68 GO:0030054; GO:0005737; GO:0046872; GO:0007528; GO:0005634; GO:0045211; GO:0021522 cell junction; cytoplasm; metal ion binding; neuromuscular junction development; nucleus; postsynaptic membrane; spinal cord motor neuron differentiation IPR018482; Zinc finger C4H2 domain-containing protein (Hepatocellular carcinoma-associated antigen 127 homolog) Zc4h2 Hca127 Kiaa1166 Mus musculus (Mouse) TR35016_c2_g1_i3 P86854 PLCL_MYTGA 3.00E-19 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR35016_c2_g1_i4 P55066 NCAN_MOUSE 4.00E-17 GO:0005509; GO:0030246; GO:0007155; GO:0005576; GO:0005540; GO:0005886; GO:0051823 calcium ion binding; carbohydrate binding; cell adhesion; extracellular region; hyaluronic acid binding; plasma membrane; regulation of synapse structural plasticity IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Neurocan core protein (Chondroitin sulfate proteoglycan 3) Ncan Cspg3 Mus musculus (Mouse) TR35016_c2_g1_i5 Q8MHZ9 CL46_BOVIN 4.00E-08 GO:0005581; GO:0005537 collagen; mannose binding IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; IPR015097; Collectin-46 (CL-46) (46 kDa collectin) CL46 Bos taurus (Bovine) TR35016_c2_g2_i3 Q2LK54 COL12_CHICK 8.00E-11 GO:0030246; GO:0005581; GO:0016021; GO:0046872 carbohydrate binding; collagen; integral to membrane; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-12 (Collectin-3) (CL-3) (cCL-3) COLEC12 CL3 Gallus gallus (Chicken) TR35016_c2_g3_i1 P20693 FCER2_MOUSE 6.00E-10 GO:0030246; GO:0009897; GO:0016021; GO:0046872; GO:0002925; GO:0051712; GO:0051000; GO:0051770 carbohydrate binding; external side of plasma membrane; integral to membrane; metal ion binding; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of killing of cells of other organism; positive regulation of nitric-oxide synthase activity; positive regulation of nitric-oxide synthase biosynthetic process IPR001304; IPR016186; IPR018378; IPR016187; Low affinity immunoglobulin epsilon Fc receptor (Fc-epsilon-RII) (Lymphocyte IgE receptor) (CD antigen CD23) Fcer2 Fcer2a Mus musculus (Mouse) TR35018_c1_g2_i1 Q6TAW2 SERP2_MOUSE 5.00E-31 GO:0005789; GO:0016021; GO:0015031 endoplasmic reticulum membrane; integral to membrane; protein transport IPR010580; Stress-associated endoplasmic reticulum protein 2 (Ribosome-associated membrane protein RAMP4-2) Serp2 Mus musculus (Mouse) TR35019_c0_g1_i1 A3KNB6 ODR4_XENLA 2.00E-32 GO:0016021; GO:0016491; GO:0008270 integral to membrane; oxidoreductase activity; zinc ion binding IPR002085; Protein odr-4 homolog odr4 Xenopus laevis (African clawed frog) TR35020_c0_g1_i1 A9JTS9 PTER_XENTR 9.00E-127 GO:0009056; GO:0016788; GO:0008270 "catabolic process; hydrolase activity, acting on ester bonds; zinc ion binding" IPR017947; IPR001559; Phosphotriesterase-related protein (EC 3.1.-.-) (Parathion hydrolase-related protein) pter Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35020_c0_g1_i2 P45548 PHP_ECOLI 5.00E-29 GO:0009056; GO:0016788; GO:0008270 P0A6F5 "catabolic process; hydrolase activity, acting on ester bonds; zinc ion binding" IPR017947; IPR001559; IPR027280; Phosphotriesterase homology protein php yhfV b3379 JW3342 Escherichia coli (strain K12) TR35024_c0_g1_i1 Q02543 RL18A_HUMAN 1.00E-89 GO:0003723; GO:0006614; GO:0022625; GO:0000184; GO:0003735; GO:0006414; GO:0006413; GO:0006415; GO:0019083 "RNA binding; SRP-dependent cotranslational protein targeting to membrane; cytosolic large ribosomal subunit; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; translational elongation; translational initiation; translational termination; viral transcription" IPR021138; IPR023573; 60S ribosomal protein L18a RPL18A Homo sapiens (Human) TR35024_c0_g1_i4 Q02543 RL18A_HUMAN 4.00E-88 GO:0003723; GO:0006614; GO:0022625; GO:0000184; GO:0003735; GO:0006414; GO:0006413; GO:0006415; GO:0019083 "RNA binding; SRP-dependent cotranslational protein targeting to membrane; cytosolic large ribosomal subunit; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; translational elongation; translational initiation; translational termination; viral transcription" IPR021138; IPR023573; 60S ribosomal protein L18a RPL18A Homo sapiens (Human) TR35026_c0_g1_i4 Q94521 DNAT_DROME 9.00E-09 GO:0004059; GO:0004060; GO:0005737; GO:0048066; GO:0042420; GO:0030187; GO:0046334; GO:0045187; GO:0042429; GO:0030431 "aralkylamine N-acetyltransferase activity; arylamine N-acetyltransferase activity; cytoplasm; developmental pigmentation; dopamine catabolic process; melatonin biosynthetic process; octopamine catabolic process; regulation of circadian sleep/wake cycle, sleep; serotonin catabolic process; sleep" IPR016181; IPR000182; Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2. Dopamine N-acetyltransferase (EC 2.3.1.87) (Arylalkylamine N-acetyltransferase) (aaNAT1) Dat NAT1 CG3318 Drosophila melanogaster (Fruit fly) TR35028_c3_g1_i1 Q75K28 NCSA_DICDI 1.00E-06 GO:0005509; GO:0030587 calcium ion binding; sorocarp development IPR011992; IPR018247; IPR002048; IPR001125; Calcium-binding protein NCSA (Neuronal calcium sensor 1 homolog) ncsA DDB_G0275931 Dictyostelium discoideum (Slime mold) TR35028_c4_g1_i1 Q9Y6T7 DGKB_HUMAN 0 GO:0005524; GO:0003951; GO:0005509; GO:0005737; GO:0004143; GO:0035556; GO:0005886; GO:0030168; GO:0007205 ATP binding; NAD+ kinase activity; calcium ion binding; cytoplasm; diacylglycerol kinase activity; intracellular signal transduction; plasma membrane; platelet activation; protein kinase C-activating G-protein coupled receptor signaling pathway IPR016064; IPR000756; IPR001206; IPR011992; IPR018247; IPR002048; IPR002219; Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta) DGKB DAGK2 KIAA0718 Homo sapiens (Human) TR35028_c4_g1_i2 Q80UP3 DGKZ_MOUSE 3.00E-76 GO:0005524; GO:0003951; GO:0005737; GO:0004143; GO:0004857; GO:0035556; GO:0046872; GO:0046580; GO:0005634; GO:0005886; GO:0007205 P13405 ATP binding; NAD+ kinase activity; cytoplasm; diacylglycerol kinase activity; enzyme inhibitor activity; intracellular signal transduction; metal ion binding; negative regulation of Ras protein signal transduction; nucleus; plasma membrane; protein kinase C-activating G-protein coupled receptor signaling pathway IPR002110; IPR020683; IPR016064; IPR000756; IPR001206; IPR002219; Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) Dgkz Mus musculus (Mouse) TR35028_c5_g2_i1 P80236 RAC1_CAVPO 6.00E-30 GO:0005525; GO:0006184; GO:0003924; GO:0060071; GO:0048532; GO:0002093; GO:0007411; GO:0048870; GO:0045216; GO:0021799; GO:0090103; GO:0007010; GO:0048813; GO:0071542; GO:0021831; GO:0043652; GO:0003382; GO:0019897; GO:0006972; GO:0030027; GO:0030032; GO:0042470; GO:0001891; GO:0030838; GO:0043552; GO:0001934; GO:0030334; GO:0097178; GO:0032587; GO:0007264; GO:0034446 "GTP binding; GTP catabolic process; GTPase activity; Wnt receptor signaling pathway, planar cell polarity pathway; anatomical structure arrangement; auditory receptor cell morphogenesis; axon guidance; cell motility; cell-cell junction organization; cerebral cortex radially oriented cell migration; cochlea morphogenesis; cytoskeleton organization; dendrite morphogenesis; dopaminergic neuron differentiation; embryonic olfactory bulb interneuron precursor migration; engulfment of apoptotic cell; epithelial cell morphogenesis; extrinsic to plasma membrane; hyperosmotic response; lamellipodium; lamellipodium assembly; melanosome; phagocytic cup; positive regulation of actin filament polymerization; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein phosphorylation; regulation of cell migration; ruffle assembly; ruffle membrane; small GTPase mediated signal transduction; substrate adhesion-dependent cell spreading" IPR027417; IPR001806; Ras-related C3 botulinum toxin substrate 1 (Sigma 1 component protein p22) (p21-Rac1) (Fragment) RAC1 Cavia porcellus (Guinea pig) TR35028_c5_g2_i2 Q6RUV5 RAC1_RAT 1.00E-44 GO:0005525; GO:0003924; GO:0000139; GO:0016601; GO:0060071; GO:0007015; GO:0048532; GO:0002093; GO:0007411; GO:0045453; GO:0008283; GO:0045216; GO:0021799; GO:0090103; GO:0031410; GO:0048813; GO:0071542; GO:0021831; GO:0043652; GO:0003382; GO:0019897; GO:0006972; GO:0030027; GO:0030032; GO:0002551; GO:0042470; GO:0001891; GO:0045740; GO:0030838; GO:0043552; GO:0001934; GO:0030334; GO:0097178; GO:0032587; GO:0034446 "GTP binding; GTPase activity; Golgi membrane; Rac protein signal transduction; Wnt receptor signaling pathway, planar cell polarity pathway; actin filament organization; anatomical structure arrangement; auditory receptor cell morphogenesis; axon guidance; bone resorption; cell proliferation; cell-cell junction organization; cerebral cortex radially oriented cell migration; cochlea morphogenesis; cytoplasmic vesicle; dendrite morphogenesis; dopaminergic neuron differentiation; embryonic olfactory bulb interneuron precursor migration; engulfment of apoptotic cell; epithelial cell morphogenesis; extrinsic to plasma membrane; hyperosmotic response; lamellipodium; lamellipodium assembly; mast cell chemotaxis; melanosome; phagocytic cup; positive regulation of DNA replication; positive regulation of actin filament polymerization; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein phosphorylation; regulation of cell migration; ruffle assembly; ruffle membrane; substrate adhesion-dependent cell spreading" IPR027417; IPR005225; IPR001806; IPR003578; Ras-related C3 botulinum toxin substrate 1 (p21-Rac1) Rac1 Rattus norvegicus (Rat) TR35032_c3_g1_i12 Q54258 STRB1_STRGA 6.00E-49 GO:0015069; GO:0019872 scyllo-inosamine-4-phosphate amidinotransferase activity; streptomycin biosynthetic process Antibiotic biosynthesis; streptomycin biosynthesis. Inosamine-phosphate amidinotransferase 1 (EC 2.1.4.2) (Aminocyclitol amidinotransferase) (ADT) (Inosamine-phosphate amidinotransferase I) strB1 Streptomyces glaucescens TR35032_c3_g1_i5 Q2HJ74 GATM_BOVIN 2.00E-79 GO:0006601; GO:0015068; GO:0016813; GO:0005743; GO:0005758 "creatine biosynthetic process; glycine amidinotransferase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines; mitochondrial inner membrane; mitochondrial intermembrane space" IPR003198; Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 1/2. "Glycine amidinotransferase, mitochondrial (EC 2.1.4.1) (L-arginine:glycine amidinotransferase) (Transamidinase)" GATM Bos taurus (Bovine) TR35032_c3_g3_i2 Q5R9B3 CJ118_PONAB 8.00E-130 Uncharacterized protein C10orf118 homolog (Fragment) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35033_c0_g1_i2 Q0CBD2 H2A_ASPTN 7.00E-36 GO:0003677; GO:0006281; GO:0000786; GO:0006334; GO:0005634 DNA binding; DNA repair; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR002119; Histone H2A hta1 ATEG_09002 Aspergillus terreus (strain NIH 2624 / FGSC A1156) TR35033_c0_g1_i3 Q2QPG9 H2AXB_ORYSJ 4.00E-37 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR002119; Probable histone H2AXb Os12g0530000 LOC_Os12g34510 Oryza sativa subsp. japonica (Rice) TR35033_c0_g1_i5 Q6YNC8 H2AZ_SHEEP 2.00E-67 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR002119; Histone H2A.Z (H2A/z) H2AFZ Ovis aries (Sheep) TR35033_c0_g1_i6 Q6YNC8 H2AZ_SHEEP 3.00E-67 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR002119; Histone H2A.Z (H2A/z) H2AFZ Ovis aries (Sheep) TR35035_c0_g2_i1 Q8BSN3 CC151_MOUSE 1.00E-74 Coiled-coil domain-containing protein 151 Ccdc151 Mus musculus (Mouse) TR35035_c0_g2_i4 Q8BSN3 CC151_MOUSE 4.00E-76 Coiled-coil domain-containing protein 151 Ccdc151 Mus musculus (Mouse) TR35038_c0_g2_i1 Q5ZID6 5NT3_CHICK 1.00E-84 GO:0008253; GO:0005783; GO:0000287; GO:0005739; GO:0000166; GO:0009117; GO:0016740 5'-nucleotidase activity; endoplasmic reticulum; magnesium ion binding; mitochondrion; nucleotide binding; nucleotide metabolic process; transferase activity IPR023214; IPR006434; Cytosolic 5'-nucleotidase 3A (EC 3.1.3.5) (Cytosolic 5'-nucleotidase 3) (Cytosolic 5'-nucleotidase III) (cN-III) (Pyrimidine 5'-nucleotidase 1) (P5'N-1) (P5N-1) (PN-I) NT5C3A NT5C3 PYN1 RCJMB04_27l2 Gallus gallus (Chicken) TR35038_c0_g2_i12 Q5ZID6 5NT3_CHICK 2.00E-85 GO:0008253; GO:0005783; GO:0000287; GO:0005739; GO:0000166; GO:0009117; GO:0016740 5'-nucleotidase activity; endoplasmic reticulum; magnesium ion binding; mitochondrion; nucleotide binding; nucleotide metabolic process; transferase activity IPR023214; IPR006434; Cytosolic 5'-nucleotidase 3A (EC 3.1.3.5) (Cytosolic 5'-nucleotidase 3) (Cytosolic 5'-nucleotidase III) (cN-III) (Pyrimidine 5'-nucleotidase 1) (P5'N-1) (P5N-1) (PN-I) NT5C3A NT5C3 PYN1 RCJMB04_27l2 Gallus gallus (Chicken) TR35038_c0_g2_i13 Q5ZID6 5NT3_CHICK 2.00E-81 GO:0008253; GO:0005783; GO:0000287; GO:0005739; GO:0000166; GO:0009117; GO:0016740 5'-nucleotidase activity; endoplasmic reticulum; magnesium ion binding; mitochondrion; nucleotide binding; nucleotide metabolic process; transferase activity IPR023214; IPR006434; Cytosolic 5'-nucleotidase 3A (EC 3.1.3.5) (Cytosolic 5'-nucleotidase 3) (Cytosolic 5'-nucleotidase III) (cN-III) (Pyrimidine 5'-nucleotidase 1) (P5'N-1) (P5N-1) (PN-I) NT5C3A NT5C3 PYN1 RCJMB04_27l2 Gallus gallus (Chicken) TR35038_c0_g2_i5 Q7SYN4 5NT3_DANRE 3.00E-81 GO:0008253; GO:0005737; GO:0000287; GO:0000166; GO:0009117; GO:0016740 5'-nucleotidase activity; cytoplasm; magnesium ion binding; nucleotide binding; nucleotide metabolic process; transferase activity IPR023214; IPR006434; Cytosolic 5'-nucleotidase 3 (EC 3.1.3.5) (Cytosolic 5'-nucleotidase III) (cN-III) nt5c3 zgc:66117 Danio rerio (Zebrafish) (Brachydanio rerio) TR35038_c0_g2_i7 Q5ZID6 5NT3_CHICK 2.00E-84 GO:0008253; GO:0005783; GO:0000287; GO:0005739; GO:0000166; GO:0009117; GO:0016740 5'-nucleotidase activity; endoplasmic reticulum; magnesium ion binding; mitochondrion; nucleotide binding; nucleotide metabolic process; transferase activity IPR023214; IPR006434; Cytosolic 5'-nucleotidase 3A (EC 3.1.3.5) (Cytosolic 5'-nucleotidase 3) (Cytosolic 5'-nucleotidase III) (cN-III) (Pyrimidine 5'-nucleotidase 1) (P5'N-1) (P5N-1) (PN-I) NT5C3A NT5C3 PYN1 RCJMB04_27l2 Gallus gallus (Chicken) TR35041_c0_g1_i2 Q5ZKW0 MTU1_CHICK 2.00E-141 GO:0005524; GO:0005739; GO:0016783; GO:0000049; GO:0008033 ATP binding; mitochondrion; sulfurtransferase activity; tRNA binding; tRNA processing IPR023382; IPR014729; IPR004506; Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.-) TRMU MTU1 RCJMB04_8p20 Gallus gallus (Chicken) TR35042_c0_g1_i3 O64792 PIGP_ARATH 2.00E-17 GO:0006506; GO:0016021; GO:0017176 GPI anchor biosynthetic process; integral to membrane; phosphatidylinositol N-acetylglucosaminyltransferase activity IPR013717; IPR016542; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (EC 2.4.1.198) At1g61280 T1F9.23 Arabidopsis thaliana (Mouse-ear cress) TR35042_c0_g1_i4 Q5R946 PIGP_PONAB 2.00E-35 GO:0006506; GO:0016021; GO:0017176 GPI anchor biosynthetic process; integral to membrane; phosphatidylinositol N-acetylglucosaminyltransferase activity IPR013717; IPR016542; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class P protein) (PIG-P) PIGP DSCR5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35042_c0_g1_i7 Q5R946 PIGP_PONAB 6.00E-34 GO:0006506; GO:0016021; GO:0017176 GPI anchor biosynthetic process; integral to membrane; phosphatidylinositol N-acetylglucosaminyltransferase activity IPR013717; IPR016542; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class P protein) (PIG-P) PIGP DSCR5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35043_c6_g2_i1 Q9JLC8 SACS_MOUSE 1.00E-11 GO:0005524; GO:0050750; GO:0005739; GO:0090084; GO:0005634 ATP binding; low-density lipoprotein particle receptor binding; mitochondrion; negative regulation of inclusion body assembly; nucleus IPR001623; IPR003594; IPR007842; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) TR35043_c6_g2_i2 Q9JLC8 SACS_MOUSE 9.00E-18 GO:0005524; GO:0050750; GO:0005739; GO:0090084; GO:0005634 ATP binding; low-density lipoprotein particle receptor binding; mitochondrion; negative regulation of inclusion body assembly; nucleus IPR001623; IPR003594; IPR007842; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) TR35044_c0_g1_i2 Q2TBF2 WSCD2_HUMAN 1.00E-36 GO:0016021 integral to membrane IPR027417; IPR002889; IPR013994; WSC domain-containing protein 2 WSCD2 KIAA0789 Homo sapiens (Human) TR35044_c0_g1_i4 Q29G54 WSCD_DROPS 6.00E-45 GO:0016021; GO:0008146 integral to membrane; sulfotransferase activity IPR027417; IPR000863; WSCD family member GA21586 GA21586 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR35044_c0_g1_i5 Q29G54 WSCD_DROPS 1.00E-44 GO:0016021; GO:0008146 integral to membrane; sulfotransferase activity IPR027417; IPR000863; WSCD family member GA21586 GA21586 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR35046_c2_g2_i1 P21328 RTJK_DROME 6.00E-06 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) TR35046_c3_g2_i1 Q95SX7 RTBS_DROME 7.00E-11 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR35049_c0_g1_i1 P54725 RD23A_HUMAN 1.00E-57 GO:0003684; GO:0019048; GO:0006289; GO:0005634; GO:0031593; GO:0045070; GO:0043161; GO:0000502; GO:0032434; GO:0003697 P68104; Q9JI78; P55036; Q13501; Q9UHD9 damaged DNA binding; modulation by virus of host morphology or physiology; nucleotide-excision repair; nucleus; polyubiquitin binding; positive regulation of viral genome replication; proteasomal ubiquitin-dependent protein catabolic process; proteasome complex; regulation of proteasomal ubiquitin-dependent protein catabolic process; single-stranded DNA binding IPR004806; IPR006636; IPR009060; IPR015940; IPR000449; IPR000626; IPR015360; UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) RAD23A Homo sapiens (Human) TR35049_c0_g1_i2 P54728 RD23B_MOUSE 1.00E-45 GO:0071942; GO:0005737; GO:0003684; GO:0000715; GO:0043161; GO:0000502; GO:0032434; GO:0006974; GO:0007283 "XPC complex; cytoplasm; damaged DNA binding; nucleotide-excision repair, DNA damage recognition; proteasomal ubiquitin-dependent protein catabolic process; proteasome complex; regulation of proteasomal ubiquitin-dependent protein catabolic process; response to DNA damage stimulus; spermatogenesis" IPR004806; IPR006636; IPR009060; IPR015940; IPR000449; IPR000626; IPR015360; UV excision repair protein RAD23 homolog B (HR23B) (mHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58) Rad23b Mhr23b Mus musculus (Mouse) TR35049_c0_g1_i3 Q54LV1 RAD23_DICDI 2.00E-26 GO:0003684; GO:0006289; GO:0005634; GO:0045335; GO:0043161 damaged DNA binding; nucleotide-excision repair; nucleus; phagocytic vesicle; proteasomal ubiquitin-dependent protein catabolic process IPR004806; IPR006636; IPR009060; IPR015940; IPR000449; IPR000626; IPR015360; UV excision repair protein RAD23 homolog (repC-binding protein A) rcbA rad23 DDB_G0286357 Dictyostelium discoideum (Slime mold) TR35050_c2_g1_i1 Q03277 PO11_SCICO 2.00E-07 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis IPR005135; IPR000477; Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 (Retrovirus-related Pol polyprotein from type I retrotransposable element R1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] (Fragment) Sciara coprophila (Fungus gnat) TR35050_c4_g1_i2 P21328 RTJK_DROME 2.00E-20 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) TR35051_c3_g2_i1 Q9SKB3 PARG1_ARATH 1.00E-37 GO:0005975; GO:0050832; GO:0004649; GO:0006970; GO:0006979; GO:0009414; GO:0048511; GO:0090332 carbohydrate metabolic process; defense response to fungus; poly(ADP-ribose) glycohydrolase activity; response to osmotic stress; response to oxidative stress; response to water deprivation; rhythmic process; stomatal closure IPR007724; Poly(ADP-ribose) glycohydrolase 1 (EC 3.2.1.143) PARG1 TEJ At2g31870 At2g31875 F20M17.9 Arabidopsis thaliana (Mouse-ear cress) TR35052_c0_g1_i1 Q7ZTY7 USE1_DANRE 1.00E-27 GO:0005789; GO:0016021; GO:0015031; GO:0016192 endoplasmic reticulum membrane; integral to membrane; protein transport; vesicle-mediated transport IPR019150; Vesicle transport protein USE1 (USE1-like protein) use1 use1l zgc:56402 Danio rerio (Zebrafish) (Brachydanio rerio) TR35052_c0_g2_i2 Q9CQ56 USE1_MOUSE 1.00E-26 GO:0005789; GO:0071786; GO:0016021; GO:0015031; GO:0060628; GO:0016192 endoplasmic reticulum membrane; endoplasmic reticulum tubular network organization; integral to membrane; protein transport; regulation of ER to Golgi vesicle-mediated transport; vesicle-mediated transport IPR019150; Vesicle transport protein USE1 (Protein D12) (USE1-like protein) Use1 Use1l Mus musculus (Mouse) TR35053_c2_g1_i2 Q9Y2G5 OFUT2_HUMAN 9.00E-87 GO:0005794; GO:0005783; GO:0006004; GO:0001707; GO:0046922; GO:0010717; GO:0010468; GO:0051046 Golgi apparatus; endoplasmic reticulum; fucose metabolic process; mesoderm formation; peptide-O-fucosyltransferase activity; regulation of epithelial to mesenchymal transition; regulation of gene expression; regulation of secretion IPR019378; Protein modification; protein glycosylation. GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 2) (O-FucT-2) POFUT2 C21orf80 FUT13 KIAA0958 Homo sapiens (Human) TR35054_c3_g2_i1 P74148 Y1388_SYNY3 2.00E-09 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein Sll1388 (USP Sll1388) sll1388 Synechocystis sp. (strain PCC 6803 / Kazusa) TR35054_c3_g2_i5 P74148 Y1388_SYNY3 8.00E-10 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein Sll1388 (USP Sll1388) sll1388 Synechocystis sp. (strain PCC 6803 / Kazusa) TR35056_c3_g2_i1 Q8NE22 SETD9_HUMAN 2.00E-73 GO:0008168 methyltransferase activity SET domain-containing protein 9 (EC 2.1.1.-) SETD9 C5orf35 Homo sapiens (Human) TR35057_c0_g1_i2 Q8R087 B4GT7_MOUSE 4.00E-105 GO:0005794; GO:0032580; GO:0043206; GO:0006024; GO:0016021; GO:0046872; GO:0048147; GO:0006486; GO:0006029; GO:0046525 Golgi apparatus; Golgi cisterna membrane; extracellular fibril organization; glycosaminoglycan biosynthetic process; integral to membrane; metal ion binding; negative regulation of fibroblast proliferation; protein glycosylation; proteoglycan metabolic process; xylosylprotein 4-beta-galactosyltransferase activity IPR003859; IPR027791; IPR027995; Protein modification; protein glycosylation. "Beta-1,4-galactosyltransferase 7 (Beta-1,4-GalTase 7) (Beta4Gal-T7) (b4Gal-T7) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7) [Includes: Xylosylprotein 4-beta-galactosyltransferase (EC 2.4.1.133) (Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I) (UDP-galactose:beta-xylose beta-1,4-galactosyltransferase) (XGPT) (XGalT-1) (Xylosylprotein beta-1,4-galactosyltransferase)]" B4galt7 Xgalt1 Mus musculus (Mouse) TR35057_c0_g1_i3 P15535 B4GT1_MOUSE 1.00E-32 GO:0005794; GO:0032580; GO:0000138; GO:0003945; GO:0002526; GO:0060055; GO:0016323; GO:0003831; GO:0007339; GO:0048754; GO:0031526; GO:0007155; GO:0009986; GO:0008092; GO:0030057; GO:0045136; GO:0002064; GO:0009897; GO:0030198; GO:0005576; GO:0006012; GO:0030112; GO:0016021; GO:0005989; GO:0004461; GO:0050900; GO:0030879; GO:0046872; GO:0008285; GO:0009312; GO:0007341; GO:0005886; GO:0060058; GO:0060054; GO:0006486; GO:0060046; GO:0051270 "Golgi apparatus; Golgi cisterna membrane; Golgi trans cisterna; N-acetyllactosamine synthase activity; acute inflammatory response; angiogenesis involved in wound healing; basolateral plasma membrane; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; binding of sperm to zona pellucida; branching morphogenesis of an epithelial tube; brush border membrane; cell adhesion; cell surface; cytoskeletal protein binding; desmosome; development of secondary sexual characteristics; epithelial cell development; external side of plasma membrane; extracellular matrix organization; extracellular region; galactose metabolic process; glycocalyx; integral to membrane; lactose biosynthetic process; lactose synthase activity; leukocyte migration; mammary gland development; metal ion binding; negative regulation of cell proliferation; oligosaccharide biosynthetic process; penetration of zona pellucida; plasma membrane; positive regulation of apoptotic process involved in mammary gland involution; positive regulation of epithelial cell proliferation involved in wound healing; protein glycosylation; regulation of acrosome reaction; regulation of cellular component movement" IPR003859; IPR027791; IPR027995; Protein modification; protein glycosylation. "Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1] [Includes: Lactose synthase A protein (EC 2.4.1.22); N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthase); Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)]" B4galt1 Ggtb Ggtb2 Mus musculus (Mouse) TR35058_c3_g6_i2 Q8K1S2 UNC5D_MOUSE 5.00E-15 GO:0006915; GO:0007411; GO:0009986; GO:0016021; GO:0021859; GO:2001222; GO:0007165 apoptotic process; axon guidance; cell surface; integral to membrane; pyramidal neuron differentiation; regulation of neuron migration; signal transduction IPR011029; IPR000488; IPR007110; IPR013783; IPR013098; IPR003598; IPR000884; IPR000906; Netrin receptor UNC5D (Protein unc-5 homolog 4) (Protein unc-5 homolog D) Unc5d Unc5h4 Mus musculus (Mouse) TR35058_c3_g6_i3 Q761X5 UNC5C_RAT 1.00E-19 GO:0006915; GO:0016021; GO:0007275; GO:0007165 apoptotic process; integral to membrane; multicellular organismal development; signal transduction IPR011029; IPR000488; IPR007110; IPR013783; IPR013098; IPR003598; IPR000884; IPR000906; Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C) Unc5c Unc5h3 Rattus norvegicus (Rat) TR35058_c4_g1_i1 O97758 ZO1_CANFA 3.00E-78 GO:0009986; GO:0071277; GO:0031410; GO:0005921; GO:0005886; GO:0005923; GO:0070830 Q2TFN9 cell surface; cellular response to calcium ion; cytoplasmic vesicle; gap junction; plasma membrane; tight junction; tight junction assembly IPR008145; IPR008144; IPR027417; IPR001478; IPR011511; IPR001452; IPR005417; IPR005418; IPR000906; Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1 ZO1 Canis familiaris (Dog) (Canis lupus familiaris) TR35058_c4_g1_i3 Q6P0D7 MPP7_DANRE 6.00E-06 GO:0005912; GO:0016020; GO:0005923 adherens junction; membrane; tight junction IPR008145; IPR008144; IPR020590; IPR004172; IPR014775; IPR027417; IPR001478; IPR011511; IPR001452; MAGUK p55 subfamily member 7 (Protein humpback) mpp7 dlg3 hmp Danio rerio (Zebrafish) (Brachydanio rerio) TR35058_c4_g1_i5 Q07157 ZO1_HUMAN 4.00E-77 GO:0045177; GO:0016324; GO:0016327; GO:0016323; GO:0001825; GO:0005913; GO:0007043; GO:1901350; GO:0006921; GO:0071333; GO:0005829; GO:0005921; GO:0035329; GO:0014704; GO:0046581; GO:0043116; GO:0005634; GO:0042493; GO:0045471; GO:0032496; GO:0071000; GO:0005923 O43707; P17302; Q8N144; Q9EPK5 apical part of cell; apical plasma membrane; apicolateral plasma membrane; basolateral plasma membrane; blastocyst formation; cell-cell adherens junction; cell-cell junction assembly; cell-cell signaling involved in cell-cell junction organization; cellular component disassembly involved in execution phase of apoptosis; cellular response to glucose stimulus; cytosol; gap junction; hippo signaling cascade; intercalated disc; intercellular canaliculus; negative regulation of vascular permeability; nucleus; response to drug; response to ethanol; response to lipopolysaccharide; response to magnetism; tight junction IPR008145; IPR008144; IPR027417; IPR001478; IPR011511; IPR001452; IPR005417; IPR005418; IPR000906; Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1 ZO1 Homo sapiens (Human) TR35060_c0_g1_i1 Q92979 NEP1_HUMAN 7.00E-62 GO:0003723; GO:0005737; GO:0005730; GO:0070037; GO:0019843; GO:0042274 RNA binding; cytoplasm; nucleolus; rRNA (pseudouridine) methyltransferase activity; rRNA binding; ribosomal small subunit biogenesis IPR005304; Ribosomal RNA small subunit methyltransferase NEP1 (EC 2.1.1.-) (18S rRNA (pseudouridine-N1-)-methyltransferase NEP1) (18S rRNA Psi1248 methyltransferase) (Nucleolar protein EMG1 homolog) (Protein C2f) (Ribosome biogenesis protein NEP1) EMG1 C2F Homo sapiens (Human) TR35061_c6_g1_i1 Q3SZJ4 PTGR1_BOVIN 7.00E-106 GO:0036132; GO:0047522; GO:0032440; GO:0005737; GO:0006693; GO:0008270 13-prostaglandin reductase activity; 15-oxoprostaglandin 13-oxidase activity; 2-alkenal reductase [NAD(P)] activity; cytoplasm; prostaglandin metabolic process; zinc ion binding IPR013149; IPR002085; IPR014190; IPR011032; IPR016040; Prostaglandin reductase 1 (PRG-1) (EC 1.3.1.-) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (NADP-dependent leukotriene B4 12-hydroxydehydrogenase) (EC 1.3.1.74) PTGR1 LTB4DH Bos taurus (Bovine) TR35062_c1_g1_i1 Q78P75 DYL2_RAT 2.00E-45 GO:0005813; GO:0005737; GO:0008092; GO:0030286; GO:0005874; GO:0007017; GO:0003774; GO:0016459; GO:0008039; GO:0006810 centrosome; cytoplasm; cytoskeletal protein binding; dynein complex; microtubule; microtubule-based process; motor activity; myosin complex; synaptic target recognition; transport IPR019763; IPR001372; "Dynein light chain 2, cytoplasmic (Dynein light chain LC8-type 2)" Dynll2 Dlc2 Rattus norvegicus (Rat) TR35062_c1_g1_i4 Q78P75 DYL2_RAT 2.00E-57 GO:0005813; GO:0005737; GO:0008092; GO:0030286; GO:0005874; GO:0007017; GO:0003774; GO:0016459; GO:0008039; GO:0006810 centrosome; cytoplasm; cytoskeletal protein binding; dynein complex; microtubule; microtubule-based process; motor activity; myosin complex; synaptic target recognition; transport IPR019763; IPR001372; "Dynein light chain 2, cytoplasmic (Dynein light chain LC8-type 2)" Dynll2 Dlc2 Rattus norvegicus (Rat) TR35065_c0_g2_i3 Q9CPT4 CS010_MOUSE 1.00E-13 GO:0005576 extracellular region IPR018887; UPF0556 protein C19orf10 homolog (Interleukin-25) (IL-25) (Stromal cell-derived growth factor SF20) D17Wsu104e Il25 Mus musculus (Mouse) TR35067_c4_g2_i1 P57077 TAK1L_HUMAN 7.00E-16 GO:0005829; GO:0005634 Q13227 cytosol; nucleus MAP3K7 C-terminal-like protein (TAK1-like protein) MAP3K7CL C21orf7 TAK1L Homo sapiens (Human) TR35067_c4_g2_i2 Q5UQG7 YR818_MIMIV 1.00E-42 GO:0005524; GO:0009190; GO:0016021; GO:0035556; GO:0016849; GO:0004674 ATP binding; cyclic nucleotide biosynthetic process; integral to membrane; intracellular signal transduction; phosphorus-oxygen lyase activity; protein serine/threonine kinase activity IPR001054; IPR011009; IPR024370; IPR000719; IPR017441; IPR001245; IPR002290; IPR008271; Putative serine/threonine-protein kinase/receptor R818 (EC 2.7.11.1) MIMI_R818 Acanthamoeba polyphaga mimivirus (APMV) TR35067_c4_g2_i3 Q62073 M3K7_MOUSE 3.00E-159 GO:0005524; GO:0007252; GO:0004708; GO:0004709; GO:0001525; GO:0006915; GO:0005737; GO:0000287; GO:2001234; GO:0060546; GO:2000378; GO:1902443; GO:0001841; GO:0005886; GO:0043123; GO:0046330; GO:0043507; GO:0006355; GO:0006950; GO:0006351; GO:0007179 Q9WVI9-2; P70340; Q8CF89; Q99K90; Q8N5C8; P39429; Q86Y07-1 "ATP binding; I-kappaB phosphorylation; MAP kinase kinase activity; MAP kinase kinase kinase activity; angiogenesis; apoptotic process; cytoplasm; magnesium ion binding; negative regulation of apoptotic signaling pathway; negative regulation of necroptosis; negative regulation of reactive oxygen species metabolic process; negative regulation of ripoptosome assembly involved in necroptosis; neural tube formation; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; positive regulation of JUN kinase activity; regulation of transcription, DNA-dependent; response to stress; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway" IPR011009; IPR017421; IPR000719; IPR017441; IPR001245; IPR008271; Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Map3k7 Tak1 Mus musculus (Mouse) TR35067_c4_g2_i4 Q9ESL4 MLTK_MOUSE 3.00E-45 GO:0005524; GO:0004709; GO:0000075; GO:0005737; GO:0007010; GO:0000287; GO:0005634; GO:0043065 ATP binding; MAP kinase kinase kinase activity; cell cycle checkpoint; cytoplasm; cytoskeleton organization; magnesium ion binding; nucleus; positive regulation of apoptotic process IPR011009; IPR000719; IPR001660; IPR013761; IPR021129; IPR001245; IPR008271; Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (Leucine zipper- and sterile alpha motif kinase ZAK) (MLK-like mitogen-activated protein triple kinase) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) Mltk Mus musculus (Mouse) TR35067_c4_g2_i5 Q62073 M3K7_MOUSE 9.00E-162 GO:0005524; GO:0007252; GO:0004708; GO:0004709; GO:0001525; GO:0006915; GO:0005737; GO:0000287; GO:2001234; GO:0060546; GO:2000378; GO:1902443; GO:0001841; GO:0005886; GO:0043123; GO:0046330; GO:0043507; GO:0006355; GO:0006950; GO:0006351; GO:0007179 Q9WVI9-2; P70340; Q8CF89; Q99K90; Q8N5C8; P39429; Q86Y07-1 "ATP binding; I-kappaB phosphorylation; MAP kinase kinase activity; MAP kinase kinase kinase activity; angiogenesis; apoptotic process; cytoplasm; magnesium ion binding; negative regulation of apoptotic signaling pathway; negative regulation of necroptosis; negative regulation of reactive oxygen species metabolic process; negative regulation of ripoptosome assembly involved in necroptosis; neural tube formation; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; positive regulation of JUN kinase activity; regulation of transcription, DNA-dependent; response to stress; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway" IPR011009; IPR017421; IPR000719; IPR017441; IPR001245; IPR008271; Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Map3k7 Tak1 Mus musculus (Mouse) TR35068_c1_g1_i1 Q6S5C2 GNPTG_MOUSE 3.00E-67 GO:0005794; GO:0005576 Golgi apparatus; extracellular region IPR009011; N-acetylglucosamine-1-phosphotransferase subunit gamma (GlcNAc-1-phosphotransferase subunit gamma) (M6PR domain-containing protein 1) (UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma) Gnptg Mdcp1 Mus musculus (Mouse) TR35068_c1_g1_i2 Q58CS8 GNPTG_BOVIN 9.00E-73 GO:0005794; GO:0005576 Golgi apparatus; extracellular region IPR009011; N-acetylglucosamine-1-phosphotransferase subunit gamma (GlcNAc-1-phosphotransferase subunit gamma) (UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma) GNPTG Bos taurus (Bovine) TR35069_c0_g1_i1 Q9VJS8 ELBOW_DROME 1.00E-10 GO:0007219; GO:0008283; GO:0035214; GO:0048737; GO:0046872; GO:0010629; GO:0003676; GO:0005634; GO:0007424; GO:0035220 Q9VDF0; P39768 Notch signaling pathway; cell proliferation; eye-antennal disc development; imaginal disc-derived appendage development; metal ion binding; negative regulation of gene expression; nucleic acid binding; nucleus; open tracheal system development; wing disc development IPR007087; IPR015880; IPR013087; Zinc finger protein Elbow elB CG4220 Drosophila melanogaster (Fruit fly) TR35069_c0_g1_i10 Q9VJS8 ELBOW_DROME 1.00E-10 GO:0007219; GO:0008283; GO:0035214; GO:0048737; GO:0046872; GO:0010629; GO:0003676; GO:0005634; GO:0007424; GO:0035220 Q9VDF0; P39768 Notch signaling pathway; cell proliferation; eye-antennal disc development; imaginal disc-derived appendage development; metal ion binding; negative regulation of gene expression; nucleic acid binding; nucleus; open tracheal system development; wing disc development IPR007087; IPR015880; IPR013087; Zinc finger protein Elbow elB CG4220 Drosophila melanogaster (Fruit fly) TR35069_c0_g1_i5 Q24423 NOC_DROME 2.00E-16 GO:0003677; GO:0007219; GO:0007420; GO:0008283; GO:0002121; GO:0035218; GO:0046872; GO:0010629; GO:0005634; GO:0008056; GO:0006357; GO:0007430; GO:0035220 Q9W512; Q9V3G9 "DNA binding; Notch signaling pathway; brain development; cell proliferation; inter-male aggressive behavior; leg disc development; metal ion binding; negative regulation of gene expression; nucleus; ocellus development; regulation of transcription from RNA polymerase II promoter; terminal branching, open tracheal system; wing disc development" IPR007087; IPR015880; IPR013087; Zinc finger protein Noc (Zinc finger protein NocA) noc nocA CG4491 Drosophila melanogaster (Fruit fly) TR35069_c0_g1_i6 Q6UFS5 ZN503_DANRE 4.00E-09 GO:0048596; GO:0030902; GO:0046872; GO:0003676; GO:0005634; GO:0006355; GO:0006351 "embryonic camera-type eye morphogenesis; hindbrain development; metal ion binding; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR022129; IPR007087; IPR015880; IPR013087; Zinc finger protein 503 (NocA-like zinc finger protein 2) znf503 nlz2 Danio rerio (Zebrafish) (Brachydanio rerio) TR35069_c0_g1_i9 Q05AQ8 ZN503_XENTR 2.00E-09 GO:0046872; GO:0003676; GO:0005634; GO:0006355; GO:0006351 "metal ion binding; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR022129; IPR007087; IPR015880; IPR013087; Zinc finger protein 503 znf503 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35070_c1_g1_i1 Q90694 CDC42_CHICK 4.00E-12 GO:0005525; GO:0003924; GO:0030036; GO:0051017; GO:0005912; GO:0034332; GO:0045177; GO:0060070; GO:0003161; GO:0034613; GO:0005737; GO:0090136; GO:0060684; GO:0035088; GO:0030175; GO:0046847; GO:0031069; GO:0060789; GO:0060047; GO:0031424; GO:0003334; GO:0045185; GO:0030496; GO:0072686; GO:0035264; GO:0010629; GO:0031333; GO:0048664; GO:0043005; GO:0043025; GO:0007097; GO:0005886; GO:0043410; GO:0032467; GO:0010628; GO:0071338; GO:0033138; GO:0043552; GO:0045860; GO:0031274; GO:1900026; GO:0051988; GO:0051489; GO:0007088; GO:0042176; GO:0043497; GO:0031647; GO:0007264; GO:0051233 GTP binding; GTPase activity; actin cytoskeleton organization; actin filament bundle assembly; adherens junction; adherens junction organization; apical part of cell; canonical Wnt receptor signaling pathway; cardiac conduction system development; cellular protein localization; cytoplasm; epithelial cell-cell adhesion; epithelial-mesenchymal cell signaling; establishment or maintenance of apical/basal cell polarity; filopodium; filopodium assembly; hair follicle morphogenesis; hair follicle placode formation; heart contraction; keratinization; keratinocyte development; maintenance of protein location; midbody; mitotic spindle; multicellular organism growth; negative regulation of gene expression; negative regulation of protein complex assembly; neuron fate determination; neuron projection; neuronal cell body; nuclear migration; plasma membrane; positive regulation of MAPK cascade; positive regulation of cytokinesis; positive regulation of gene expression; positive regulation of hair follicle cell proliferation; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein kinase activity; positive regulation of pseudopodium assembly; positive regulation of substrate adhesion-dependent cell spreading; regulation of attachment of spindle microtubules to kinetochore; regulation of filopodium assembly; regulation of mitosis; regulation of protein catabolic process; regulation of protein heterodimerization activity; regulation of protein stability; small GTPase mediated signal transduction; spindle midzone IPR027417; IPR005225; IPR001806; IPR003578; Cell division control protein 42 homolog (G25K GTP-binding protein) CDC42 Gallus gallus (Chicken) TR35070_c1_g2_i1 P60764 RAC3_MOUSE 1.00E-31 GO:0005525; GO:0003924; GO:0030036; GO:0030031; GO:0005737; GO:0012505; GO:0031941; GO:0030426; GO:0030027; GO:0016020; GO:0050885; GO:0031175; GO:0043025; GO:0007264 Q99PT1 GTP binding; GTPase activity; actin cytoskeleton organization; cell projection assembly; cytoplasm; endomembrane system; filamentous actin; growth cone; lamellipodium; membrane; neuromuscular process controlling balance; neuron projection development; neuronal cell body; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Ras-related C3 botulinum toxin substrate 3 (p21-Rac3) Rac3 Mus musculus (Mouse) TR35070_c1_g2_i3 Q00246 RHO4_YEAST 5.00E-28 GO:0005525; GO:0003924; GO:0005935; GO:0000131; GO:0030011; GO:0005886; GO:0090338; GO:0007264 GTP binding; GTPase activity; cellular bud neck; incipient cellular bud site; maintenance of cell polarity; plasma membrane; positive regulation of formin-nucleated actin cable assembly; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; GTP-binding protein RHO4 RHO4 YKR055W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR35075_c0_g1_i1 Q3UDP0 WDR41_MOUSE 8.00E-44 IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 41 Wdr41 Mus musculus (Mouse) TR35076_c2_g1_i1 P17213 BPI_HUMAN 6.00E-17 GO:0005737; GO:0042742; GO:0005576; GO:0006955; GO:0005887; GO:0001530; GO:0032715; GO:0032717; GO:0043031; GO:0032720 cytoplasm; defense response to bacterium; extracellular region; immune response; integral to plasma membrane; lipopolysaccharide binding; negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; negative regulation of macrophage activation; negative regulation of tumor necrosis factor production IPR017943; IPR001124; IPR017954; IPR017942; Bactericidal permeability-increasing protein (BPI) (CAP 57) BPI Homo sapiens (Human) TR35076_c2_g3_i1 Q61805 LBP_MOUSE 2.00E-17 GO:0006953; GO:0009986; GO:0071223; GO:0050829; GO:0050830; GO:0032490; GO:0005615; GO:0045087; GO:0002232; GO:0001530; GO:0015920; GO:0031663; GO:0070891; GO:0002281; GO:0044130; GO:0032720; GO:0008228; GO:0032722; GO:0032755; GO:0032757; GO:0043032; GO:0090023; GO:0060265; GO:0034145; GO:0042535; GO:0032760; GO:0005102; GO:0032496 acute-phase response; cell surface; cellular response to lipoteichoic acid; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; detection of molecule of bacterial origin; extracellular space; innate immune response; leukocyte chemotaxis involved in inflammatory response; lipopolysaccharide binding; lipopolysaccharide transport; lipopolysaccharide-mediated signaling pathway; lipoteichoic acid binding; macrophage activation involved in immune response; negative regulation of growth of symbiont in host; negative regulation of tumor necrosis factor production; opsonization; positive regulation of chemokine production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of macrophage activation; positive regulation of neutrophil chemotaxis; positive regulation of respiratory burst involved in inflammatory response; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of tumor necrosis factor production; receptor binding; response to lipopolysaccharide IPR017943; IPR001124; IPR017954; IPR017942; Lipopolysaccharide-binding protein (LBP) Lbp Mus musculus (Mouse) TR35077_c0_g3_i1 Q16831 UPP1_HUMAN 1.00E-102 GO:0044206; GO:0042149; GO:0005829; GO:0009166; GO:0006206; GO:0046135; GO:0043097; GO:0046108; GO:0004850 UMP salvage; cellular response to glucose starvation; cytosol; nucleotide catabolic process; pyrimidine nucleobase metabolic process; pyrimidine nucleoside catabolic process; pyrimidine nucleoside salvage; uridine metabolic process; uridine phosphorylase activity IPR018017; IPR018016; IPR000845; IPR010059; Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1. Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3) UPP1 UP Homo sapiens (Human) TR35077_c0_g3_i2 O08444 UDP_ENTAE 1.00E-09 GO:0044206; GO:0005737; GO:0009166; GO:0004850 UMP salvage; cytoplasm; nucleotide catabolic process; uridine phosphorylase activity IPR018017; IPR018016; IPR000845; IPR010058; Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1. Uridine phosphorylase (UPase) (UrdPase) (EC 2.4.2.3) udp Enterobacter aerogenes (Aerobacter aerogenes) TR35078_c1_g1_i1 Q15262 PTPRK_HUMAN 7.00E-67 GO:0005912; GO:0030424; GO:0016477; GO:0009986; GO:0005911; GO:0034644; GO:0034614; GO:0030425; GO:0048041; GO:0005887; GO:0031256; GO:0045786; GO:0030336; GO:0010839; GO:0045892; GO:0043025; GO:0001750; GO:0034394; GO:0007179; GO:0005001 P04626; Q02763 "adherens junction; axon; cell migration; cell surface; cell-cell junction; cellular response to UV; cellular response to reactive oxygen species; dendrite; focal adhesion assembly; integral to plasma membrane; leading edge membrane; negative regulation of cell cycle; negative regulation of cell migration; negative regulation of keratinocyte proliferation; negative regulation of transcription, DNA-dependent; neuronal cell body; photoreceptor outer segment; protein localization to cell surface; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine phosphatase activity" IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) TR35079_c2_g1_i1 Q9DG12 ARNT2_DANRE 0 GO:0003677; GO:0005737; GO:0007275; GO:0005634; GO:0046982; GO:0001666; GO:0003700; GO:0004871; GO:0007165; GO:0005667; GO:0006351 "DNA binding; cytoplasm; multicellular organismal development; nucleus; protein heterodimerization activity; response to hypoxia; sequence-specific DNA binding transcription factor activity; signal transducer activity; signal transduction; transcription factor complex; transcription, DNA-dependent" IPR011598; IPR001067; IPR001610; IPR000014; IPR013767; Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2) (zfARNT2) arnt2 Danio rerio (Zebrafish) (Brachydanio rerio) TR35079_c2_g1_i2 O02748 ARNT_RABIT 0 GO:0003677; GO:0005737; GO:0005634; GO:0003700; GO:0004871; GO:0005667; GO:0006351 "DNA binding; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; signal transducer activity; transcription factor complex; transcription, DNA-dependent" IPR011598; IPR001067; IPR001610; IPR000014; IPR013767; "Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)" ARNT Oryctolagus cuniculus (Rabbit) TR35080_c2_g1_i2 O88447 KLC1_MOUSE 9.00E-09 GO:0030424; GO:0008088; GO:0035253; GO:0031410; GO:0005829; GO:0005871; GO:0005874; GO:0003777; GO:0035617 P63017; Q9ESN9; P68619 axon; axon cargo transport; ciliary rootlet; cytoplasmic vesicle; cytosol; kinesin complex; microtubule; microtubule motor activity; stress granule disassembly IPR002151; IPR015390; IPR013026; IPR011990; IPR001440; IPR013105; IPR019734; Kinesin light chain 1 (KLC 1) Klc1 Kns2 Mus musculus (Mouse) TR35080_c2_g1_i3 P0CI65 NPHP3_DANRE 3.00E-06 GO:0016055; GO:0060271; GO:0072372 Wnt receptor signaling pathway; cilium morphogenesis; primary cilium IPR027417; IPR013026; IPR011990; IPR019734; Nephrocystin-3 nphp3 si:dkey-56l10.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR35080_c2_g1_i4 Q92624 APBP2_HUMAN 0 GO:0030659; GO:0006886; GO:0005874; GO:0005875; GO:0003777; GO:0005634 Q6ZMV9; Q969V5; P23511; Q4U2R8; Q9BT88 cytoplasmic vesicle membrane; intracellular protein transport; microtubule; microtubule associated complex; microtubule motor activity; nucleus IPR013026; IPR011990; IPR019734; Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) (Protein interacting with APP tail 1) APPBP2 KIAA0228 PAT1 Homo sapiens (Human) TR35081_c0_g1_i1 Q3SZI1 TINAG_BOVIN 9.00E-08 GO:0005604; GO:0007155; GO:0008234; GO:0006955; GO:0030247; GO:0006508; GO:0005044 basement membrane; cell adhesion; cysteine-type peptidase activity; immune response; polysaccharide binding; proteolysis; scavenger receptor activity IPR025661; IPR013128; IPR000668; IPR001212; Tubulointerstitial nephritis antigen (TIN-Ag) TINAG Bos taurus (Bovine) TR35081_c0_g1_i2 P43510 CPR6_CAEEL 1.00E-11 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; Cathepsin B-like cysteine proteinase 6 (EC 3.4.22.-) (Cysteine protease-related 6) cpr-6 C25B8.3 Caenorhabditis elegans TR35081_c0_g3_i1 P25784 CYSP3_HOMAM 1.00E-67 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Digestive cysteine proteinase 3 (EC 3.4.22.-) LCP3 Homarus americanus (American lobster) TR35081_c0_g3_i3 P25792 CYSP_SCHMA 3.00E-12 GO:0004197; GO:0006508; GO:0050790 cysteine-type endopeptidase activity; proteolysis; regulation of catalytic activity IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR012599; Cathepsin B-like cysteine proteinase (EC 3.4.22.-) (Antigen Sm31) Schistosoma mansoni (Blood fluke) TR35081_c0_g3_i4 Q95029 CATL_DROME 9.00E-75 GO:0008234; GO:0007586; GO:0045169; GO:0005764; GO:0006508; GO:0035071 cysteine-type peptidase activity; digestion; fusome; lysosome; proteolysis; salivary gland cell autophagic cell death IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L (EC 3.4.22.15) (Cysteine proteinase 1) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] Cp1 fs(2)50Ca CG6692 Drosophila melanogaster (Fruit fly) TR35081_c0_g4_i1 Q60HG6 CATC_MACFA 2.00E-19 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR014882; IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] CTSC QnpA-12394 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR35081_c0_g4_i2 P43509 CPR5_CAEEL 1.00E-14 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; Cathepsin B-like cysteine proteinase 5 (EC 3.4.22.-) (Cysteine protease-related 5) cpr-5 W07B8.5 Caenorhabditis elegans TR35081_c0_g4_i3 P00787 CATB_RAT 6.00E-12 GO:0016324; GO:0006914; GO:0004197; GO:0009897; GO:0005615; GO:0005764; GO:0042470; GO:0005739; GO:0060548; GO:0042277; GO:0043621; GO:0006508; GO:0050790; GO:0014075; GO:0045471; GO:0009749; GO:0070670; GO:0009612; GO:0014070; GO:0043434; GO:0009611; GO:0042383; GO:0007519; GO:0007283 apical plasma membrane; autophagy; cysteine-type endopeptidase activity; external side of plasma membrane; extracellular space; lysosome; melanosome; mitochondrion; negative regulation of cell death; peptide binding; protein self-association; proteolysis; regulation of catalytic activity; response to amine stimulus; response to ethanol; response to glucose stimulus; response to interleukin-4; response to mechanical stimulus; response to organic cyclic compound; response to peptide hormone stimulus; response to wounding; sarcolemma; skeletal muscle tissue development; spermatogenesis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR012599; Cathepsin B (EC 3.4.22.1) (Cathepsin B1) (RSG-2) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] Ctsb Rattus norvegicus (Rat) TR35082_c0_g1_i1 Q1LZ79 GEMI8_BOVIN 1.00E-25 GO:0097504; GO:0032797; GO:0005737; GO:0005681; GO:0000387 Gemini of coiled bodies; SMN complex; cytoplasm; spliceosomal complex; spliceosomal snRNP assembly Gem-associated protein 8 (Gemin-8) GEMIN8 Bos taurus (Bovine) TR35082_c0_g1_i3 Q1LZ79 GEMI8_BOVIN 2.00E-26 GO:0097504; GO:0032797; GO:0005737; GO:0005681; GO:0000387 Gemini of coiled bodies; SMN complex; cytoplasm; spliceosomal complex; spliceosomal snRNP assembly Gem-associated protein 8 (Gemin-8) GEMIN8 Bos taurus (Bovine) TR35083_c0_g1_i1 P37119 C71A3_SOLME 2.00E-06 GO:0020037; GO:0005506; GO:0004497; GO:0016705 "heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR002401; Cytochrome P450 71A3 (EC 1.14.-.-) (CYPLXXIA3) (Cytochrome P-450EG3) (Fragment) CYP71A3 CYPEG3 Solanum melongena (Eggplant) (Aubergine) TR35083_c0_g2_i1 Q8TAV3 CP2W1_HUMAN 6.00E-39 GO:0005789; GO:0020037; GO:0005506; GO:0004497; GO:0016705; GO:0044281; GO:0006805 "endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; small molecule metabolic process; xenobiotic metabolic process" IPR001128; IPR017972; IPR002401; Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1) CYP2W1 Homo sapiens (Human) TR35083_c0_g2_i2 Q7Z449 CP2U1_HUMAN 5.00E-52 GO:0070330; GO:0008219; GO:0005789; GO:0020037; GO:0016021; GO:0005506; GO:0097267; GO:0006805 aromatase activity; cell death; endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding; omega-hydroxylase P450 pathway; xenobiotic metabolic process IPR001128; IPR017972; IPR002401; IPR008069; Cytochrome P450 2U1 (EC 1.14.14.1) CYP2U1 Homo sapiens (Human) TR35084_c0_g2_i1 Q9JLC8 SACS_MOUSE 1.00E-12 GO:0005524; GO:0050750; GO:0005739; GO:0090084; GO:0005634 ATP binding; low-density lipoprotein particle receptor binding; mitochondrion; negative regulation of inclusion body assembly; nucleus IPR001623; IPR003594; IPR007842; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) TR35085_c0_g2_i2 P04088 INHBB_PIG 2.00E-14 GO:0032924; GO:0032869; GO:0009267; GO:0005576; GO:0045444; GO:0040007; GO:0046882; GO:0048178; GO:0046676; GO:0048471; GO:0046881; GO:0060279; GO:0042803; GO:0009612 activin receptor signaling pathway; cellular response to insulin stimulus; cellular response to starvation; extracellular region; fat cell differentiation; growth; negative regulation of follicle-stimulating hormone secretion; negative regulation of hepatocyte growth factor biosynthetic process; negative regulation of insulin secretion; perinuclear region of cytoplasm; positive regulation of follicle-stimulating hormone secretion; positive regulation of ovulation; protein homodimerization activity; response to mechanical stimulus IPR000381; IPR001839; IPR001111; IPR015615; IPR017948; Inhibin beta B chain (Activin beta-B chain) INHBB Sus scrofa (Pig) TR35085_c0_g2_i3 P04088 INHBB_PIG 6.00E-14 GO:0032924; GO:0032869; GO:0009267; GO:0005576; GO:0045444; GO:0040007; GO:0046882; GO:0048178; GO:0046676; GO:0048471; GO:0046881; GO:0060279; GO:0042803; GO:0009612 activin receptor signaling pathway; cellular response to insulin stimulus; cellular response to starvation; extracellular region; fat cell differentiation; growth; negative regulation of follicle-stimulating hormone secretion; negative regulation of hepatocyte growth factor biosynthetic process; negative regulation of insulin secretion; perinuclear region of cytoplasm; positive regulation of follicle-stimulating hormone secretion; positive regulation of ovulation; protein homodimerization activity; response to mechanical stimulus IPR000381; IPR001839; IPR001111; IPR015615; IPR017948; Inhibin beta B chain (Activin beta-B chain) INHBB Sus scrofa (Pig) TR35088_c4_g1_i1 P37193 ADXH_DROME 6.00E-62 GO:0051537; GO:0009055; GO:0046872; GO:0005759; GO:0055114 "2 iron, 2 sulfur cluster binding; electron carrier activity; metal ion binding; mitochondrial matrix; oxidation-reduction process" IPR001041; IPR001055; IPR018298; IPR012675; "Adrenodoxin-like protein, mitochondrial" Fdxh CG4205 Drosophila melanogaster (Fruit fly) TR35089_c0_g2_i2 Q25190 5HTR_HELVI 4.00E-07 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR000276; IPR017452; 5-hydroxytryptamine receptor (5-HT receptor) (Serotonin receptor) Heliothis virescens (Tobacco budworm moth) TR35089_c0_g2_i3 O02835 NPY1R_PIG 1.00E-09 GO:0007631; GO:0006006; GO:0016021; GO:0007626; GO:0003151; GO:0001602; GO:0001601; GO:0005886; GO:0008217; GO:0040014; GO:0019233 feeding behavior; glucose metabolic process; integral to membrane; locomotory behavior; outflow tract morphogenesis; pancreatic polypeptide receptor activity; peptide YY receptor activity; plasma membrane; regulation of blood pressure; regulation of multicellular organism growth; sensory perception of pain IPR000276; IPR017452; IPR000351; IPR000611; Neuropeptide Y receptor type 1 (NPY1-R) NPY1R Sus scrofa (Pig) TR3509_c0_g1_i1 P48057 SC6A1_MUSCO 5.00E-18 GO:0005332; GO:0005887; GO:0005328 gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR002980; Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) Slc6a1 Gabt1 Gat-1 Gat1 Mus cookii (Cook's mouse) TR35090_c0_g1_i1 Q56R14 TRI33_XENLA 9.00E-07 GO:0003677; GO:0016874; GO:0005634; GO:0016567; GO:0006355; GO:0006351; GO:0008270 "DNA binding; ligase activity; nucleus; protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 ecto Xenopus laevis (African clawed frog) TR35091_c2_g1_i2 Q5RF84 UB2G2_PONAB 6.00E-96 GO:0005524; GO:0030433; GO:0070936; GO:0018279; GO:0004842 ATP binding; ER-associated protein catabolic process; protein K48-linked ubiquitination; protein N-linked glycosylation via asparagine; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 G2 (EC 6.3.2.19) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2) UBE2G2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35092_c0_g1_i1 P0CP46 PABP_CRYNJ 0 GO:0003723; GO:0005737; GO:0006397; GO:0051028; GO:0000166; GO:0005634; GO:0006417 RNA binding; cytoplasm; mRNA processing; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR012677; IPR006515; IPR002004; IPR000504; "Polyadenylate-binding protein, cytoplasmic and nuclear (PABP) (Poly(A)-binding protein) (Polyadenylate tail-binding protein)" PAB1 CNI01160 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR35092_c0_g1_i3 Q9EPH8 PABP1_RAT 0 GO:0008380; GO:0010494; GO:0031047; GO:0006397; GO:2000623; GO:0000184; GO:0000166; GO:0008143; GO:1900153; GO:0060213; GO:0005681 P35570 "RNA splicing; cytoplasmic stress granule; gene silencing by RNA; mRNA processing; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleotide binding; poly(A) RNA binding; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; spliceosomal complex" IPR012677; IPR006515; IPR002004; IPR000504; Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) Pabpc1 Pabp1 Rattus norvegicus (Rat) TR35093_c1_g1_i1 Q9WTQ7 GA45G_RAT 2.00E-15 GO:0006915; GO:0030154; GO:0007275; GO:0005634; GO:0051726; GO:0006950 apoptotic process; cell differentiation; multicellular organismal development; nucleus; regulation of cell cycle; response to stress IPR024824; IPR004038; Growth arrest and DNA damage-inducible protein GADD45 gamma Gadd45g Rattus norvegicus (Rat) TR35093_c1_g1_i2 Q5E9A5 GA45B_BOVIN 8.00E-14 GO:0000186; GO:0006915; GO:0030154; GO:0007275; GO:0006469; GO:0005634; GO:0051726; GO:0006950 activation of MAPKK activity; apoptotic process; cell differentiation; multicellular organismal development; negative regulation of protein kinase activity; nucleus; regulation of cell cycle; response to stress IPR024824; IPR004038; Growth arrest and DNA damage-inducible protein GADD45 beta GADD45B Bos taurus (Bovine) TR35094_c0_g1_i2 P20654 PP1_EMENI 5.00E-157 GO:0000076; GO:0051211; GO:0030437; GO:0007114; GO:0030428; GO:0006873; GO:0007059; GO:0000778; GO:0030010; GO:0016576; GO:0005847; GO:0001400; GO:0046872; GO:0007067; GO:0000022; GO:0005730; GO:0034501; GO:0004722; GO:0006364; GO:0051726; GO:0031297; GO:0005816; GO:0030847; GO:0030846 "DNA replication checkpoint; anisotropic cell growth; ascospore formation; cell budding; cell septum; cellular ion homeostasis; chromosome segregation; condensed nuclear chromosome kinetochore; establishment of cell polarity; histone dephosphorylation; mRNA cleavage and polyadenylation specificity factor complex; mating projection base; metal ion binding; mitosis; mitotic spindle elongation; nucleolus; protein localization to kinetochore; protein serine/threonine phosphatase activity; rRNA processing; regulation of cell cycle; replication fork processing; spindle pole body; termination of RNA polymerase II transcription, exosome-dependent; termination of RNA polymerase II transcription, poly(A)-coupled" IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1 (EC 3.1.3.16) bimG AN0410 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR35095_c1_g1_i1 Q56A24 KLH24_RAT 6.00E-77 GO:0030424; GO:0005737; GO:0043204 axon; cytoplasm; perikaryon IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) Klhl24 Dre1 Rattus norvegicus (Rat) TR35095_c1_g1_i2 Q9LK86 FBK71_ARATH 7.00E-07 IPR001810; IPR015916; IPR006652; Putative F-box/kelch-repeat protein At3g27910 At3g27910 K16N12.16 Arabidopsis thaliana (Mouse-ear cress) TR35095_c1_g1_i3 Q6PF15 KLH35_HUMAN 9.00E-39 IPR011705; IPR015916; IPR006652; Kelch-like protein 35 KLHL35 Homo sapiens (Human) TR35097_c0_g1_i1 Q9HFE5 AP1M1_SCHPO 0 GO:0030121; GO:0032153; GO:0051286; GO:0030276; GO:0005905; GO:0005829; GO:0016197; GO:0005768; GO:0006886; GO:0044732; GO:0005634; GO:0032465; GO:0060237; GO:0042144; GO:0016192 "AP-1 adaptor complex; cell division site; cell tip; clathrin binding; coated pit; cytosol; endosomal transport; endosome; intracellular protein transport; mitotic spindle pole body; nucleus; regulation of cytokinesis; regulation of fungal-type cell wall organization; vacuole fusion, non-autophagic; vesicle-mediated transport" IPR022775; IPR001392; IPR008968; IPR018240; IPR011012; AP-1 complex subunit mu-1 (Clathrin assembly protein complex 1 mu-1 medium chain) (Mu-adaptin) apm1 SPBP16F5.07 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR35097_c0_g1_i2 Q9BXS5 AP1M1_HUMAN 0 GO:0000139; GO:0019886; GO:0030131; GO:0030665; GO:0030659; GO:0005829; GO:0035646; GO:0006886; GO:0005765; GO:0032438; GO:0019048; GO:0006892; GO:0050690; GO:0032588; GO:0016032 O95751; Q14872 Golgi membrane; antigen processing and presentation of exogenous peptide antigen via MHC class II; clathrin adaptor complex; clathrin-coated vesicle membrane; cytoplasmic vesicle membrane; cytosol; endosome to melanosome transport; intracellular protein transport; lysosomal membrane; melanosome organization; modulation by virus of host morphology or physiology; post-Golgi vesicle-mediated transport; regulation of defense response to virus by virus; trans-Golgi network membrane; viral process IPR022775; IPR001392; IPR008968; IPR018240; IPR011012; AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adapter-related protein complex 1 subunit mu-1) (Adaptor protein complex AP-1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin) AP1M1 CLTNM Homo sapiens (Human) TR35097_c0_g1_i4 Q09236 COPD_CAEEL 9.00E-08 GO:0030126; GO:0030131; GO:0006886; GO:0006890 "COPI vesicle coat; clathrin adaptor complex; intracellular protein transport; retrograde vesicle-mediated transport, Golgi to ER" IPR022775; IPR008968; IPR027059; IPR011012; Probable coatomer subunit delta (Delta-coat protein) (Delta-COP) C13B9.3 Caenorhabditis elegans TR35100_c0_g1_i1 Q9DC53 CPNE8_MOUSE 0 IPR000008; IPR010734; IPR002035; Copine-8 (Copine VIII) Cpne8 Mus musculus (Mouse) TR35101_c0_g1_i2 Q86WC4 OSTM1_HUMAN 2.00E-16 GO:0005829; GO:0016021; GO:0034220; GO:0005765; GO:0030316 cytosol; integral to membrane; ion transmembrane transport; lysosomal membrane; osteoclast differentiation IPR019172; Osteopetrosis-associated transmembrane protein 1 (Chloride channel 7 beta subunit) OSTM1 GL HSPC019 UNQ6098/PRO21201 Homo sapiens (Human) TR35101_c0_g1_i3 Q86WC4 OSTM1_HUMAN 2.00E-16 GO:0005829; GO:0016021; GO:0034220; GO:0005765; GO:0030316 cytosol; integral to membrane; ion transmembrane transport; lysosomal membrane; osteoclast differentiation IPR019172; Osteopetrosis-associated transmembrane protein 1 (Chloride channel 7 beta subunit) OSTM1 GL HSPC019 UNQ6098/PRO21201 Homo sapiens (Human) TR35102_c0_g1_i2 Q1PRL4 LIN41_CHICK 7.00E-08 GO:0000082; GO:0000932; GO:0008543; GO:0035198; GO:0010586; GO:0035278; GO:0001843; GO:0021915; GO:2000637; GO:0051865; GO:0060964; GO:2000177; GO:0072089; GO:0004842; GO:0008270 G1/S transition of mitotic cell cycle; cytoplasmic mRNA processing body; fibroblast growth factor receptor signaling pathway; miRNA binding; miRNA metabolic process; negative regulation of translation involved in gene silencing by miRNA; neural tube closure; neural tube development; positive regulation of gene silencing by miRNA; protein autoubiquitination; regulation of gene silencing by miRNA; regulation of neural precursor cell proliferation; stem cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Gallus gallus (Chicken) TR35102_c1_g2_i1 Q9Z0E3 AIRE_MOUSE 8.00E-12 GO:0015629; GO:0003682; GO:0005737; GO:0042393; GO:0006959; GO:0005634; GO:0005886; GO:0045944; GO:0006417; GO:0044212; GO:0006351; GO:0045182; GO:0008270 Itself "actin cytoskeleton; chromatin binding; cytoplasm; histone binding; humoral immune response; nucleus; plasma membrane; positive regulation of transcription from RNA polymerase II promoter; regulation of translation; transcription regulatory region DNA binding; transcription, DNA-dependent; translation regulator activity; zinc ion binding" IPR008087; IPR000770; IPR010919; IPR004865; IPR019786; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog) Aire Mus musculus (Mouse) TR35102_c1_g2_i3 Q6E2N3 TRI33_DANRE 1.00E-49 GO:0003677; GO:0016874; GO:0005634; GO:0016567; GO:0006355; GO:0006351; GO:0008270 "DNA binding; ligase activity; nucleus; protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (Protein moonshine) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 mon Danio rerio (Zebrafish) (Brachydanio rerio) TR35102_c1_g2_i4 Q6E2N3 TRI33_DANRE 5.00E-28 GO:0003677; GO:0016874; GO:0005634; GO:0016567; GO:0006355; GO:0006351; GO:0008270 "DNA binding; ligase activity; nucleus; protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (Protein moonshine) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 mon Danio rerio (Zebrafish) (Brachydanio rerio) TR35104_c0_g1_i1 Q01603 PERO_DROME 8.00E-82 GO:0042600; GO:0007306; GO:0005576; GO:0020037; GO:0042744; GO:0046872; GO:0022008; GO:0004601; GO:0006909 chorion; eggshell chorion assembly; extracellular region; heme binding; hydrogen peroxide catabolic process; metal ion binding; neurogenesis; peroxidase activity; phagocytosis IPR010255; IPR002007; IPR019791; Peroxidase (DmPO) (EC 1.11.1.7) (Chorion peroxidase) Pxd HDC14047 PO CG3477 Drosophila melanogaster (Fruit fly) TR35105_c3_g1_i11 Q9R044 NPHN_RAT 5.00E-15 GO:0007155; GO:0003094; GO:0016021; GO:0045121; GO:0007517; GO:0005886; GO:0043234; GO:0036057 P97710 cell adhesion; glomerular filtration; integral to membrane; membrane raft; muscle organ development; plasma membrane; protein complex; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Rattus norvegicus (Rat) TR35105_c3_g1_i14 P31809 CEAM1_MOUSE 2.00E-09 GO:0060170; GO:0009897; GO:0007156; GO:0016021; GO:0019048; GO:0043406; GO:0009615; GO:0001618 cilium membrane; external side of plasma membrane; homophilic cell adhesion; integral to membrane; modulation by virus of host morphology or physiology; positive regulation of MAP kinase activity; response to virus; virus receptor activity IPR007110; IPR013783; IPR003598; IPR013106; IPR013151; Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a) Ceacam1 Bgp Bgp1 Bgpd Mus musculus (Mouse) TR35105_c3_g1_i2 P13590 NCAM1_CHICK 4.00E-08 GO:0007155; GO:0016021; GO:0005886 cell adhesion; integral to membrane; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR009138; Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) NCAM1 Gallus gallus (Chicken) TR35105_c3_g1_i4 Q9R044 NPHN_RAT 1.00E-14 GO:0007155; GO:0003094; GO:0016021; GO:0045121; GO:0007517; GO:0005886; GO:0043234; GO:0036057 P97710 cell adhesion; glomerular filtration; integral to membrane; membrane raft; muscle organ development; plasma membrane; protein complex; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Rattus norvegicus (Rat) TR35105_c3_g1_i5 Q9QZS7 NPHN_MOUSE 7.00E-14 GO:0007254; GO:0007155; GO:0042995; GO:0032836; GO:0072015; GO:0005887; GO:0007520; GO:0030838; GO:0044062; GO:0007519; GO:0036057 JNK cascade; cell adhesion; cell projection; glomerular basement membrane development; glomerular visceral epithelial cell development; integral to plasma membrane; myoblast fusion; positive regulation of actin filament polymerization; regulation of excretion; skeletal muscle tissue development; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Mus musculus (Mouse) TR35105_c3_g1_i6 O60500 NPHN_HUMAN 7.00E-15 GO:0007254; GO:0007155; GO:0042995; GO:0007588; GO:0032836; GO:0072015; GO:0005887; GO:0007520; GO:0030838; GO:0044062; GO:0007519; GO:0036057 P46940; P16333 JNK cascade; cell adhesion; cell projection; excretion; glomerular basement membrane development; glomerular visceral epithelial cell development; integral to plasma membrane; myoblast fusion; positive regulation of actin filament polymerization; regulation of excretion; skeletal muscle tissue development; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) NPHS1 NPHN Homo sapiens (Human) TR35105_c3_g1_i9 O60500 NPHN_HUMAN 7.00E-16 GO:0007254; GO:0007155; GO:0042995; GO:0007588; GO:0032836; GO:0072015; GO:0005887; GO:0007520; GO:0030838; GO:0044062; GO:0007519; GO:0036057 P46940; P16333 JNK cascade; cell adhesion; cell projection; excretion; glomerular basement membrane development; glomerular visceral epithelial cell development; integral to plasma membrane; myoblast fusion; positive regulation of actin filament polymerization; regulation of excretion; skeletal muscle tissue development; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) NPHS1 NPHN Homo sapiens (Human) TR35108_c2_g2_i1 Q09813 T111_SCHPO 6.00E-31 GO:0000991; GO:0003676; GO:0006355; GO:0005669; GO:0006367; GO:0008270 "core RNA polymerase II binding transcription factor activity; nucleic acid binding; regulation of transcription, DNA-dependent; transcription factor TFIID complex; transcription initiation from RNA polymerase II promoter; zinc ion binding" IPR022591; IPR001878; Putative transcription initiation factor TFIID 111 kDa subunit (TAFII-111) (TBP-associated factor 111 kDa) SPAC2G11.14 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR35108_c2_g2_i2 P46677 TAF1_YEAST 8.00E-34 GO:0051123; GO:0017025; GO:0003682; GO:0005829; GO:0004402; GO:0003676; GO:0032947; GO:0006355; GO:0005669; GO:0008270 P35817; P23255; P50105; P53040 "RNA polymerase II transcriptional preinitiation complex assembly; TBP-class protein binding; chromatin binding; cytosol; histone acetyltransferase activity; nucleic acid binding; protein complex scaffold; regulation of transcription, DNA-dependent; transcription factor TFIID complex; zinc ion binding" IPR022591; IPR001878; Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (TAFII-130) (TAFII-145) (TBP-associated factor 1) (TBP-associated factor 145 kDa) TAF1 TAF130 TAF145 YGR274C G9374 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR35108_c2_g3_i1 Q60544 TAF1_MESAU 0 GO:0005524; GO:0003677; GO:0006352; GO:0071339; GO:0004402; GO:0000080; GO:0045944; GO:0004674; GO:0005669 "ATP binding; DNA binding; DNA-dependent transcription, initiation; MLL1 complex; histone acetyltransferase activity; mitotic G1 phase; positive regulation of transcription from RNA polymerase II promoter; protein serine/threonine kinase activity; transcription factor TFIID complex" IPR001487; IPR018359; IPR011177; IPR009067; IPR022591; Transcription initiation factor TFIID subunit 1 (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250) TAF1 CCG1 Mesocricetus auratus (Golden hamster) TR35109_c3_g5_i1 Q5VVH5 IKBP1_HUMAN 1.00E-49 GO:0007249; GO:0005737; GO:0005634; GO:0006355; GO:0006351 "I-kappaB kinase/NF-kappaB cascade; cytoplasm; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007497; Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1-binding protein 1) IRAK1BP1 Homo sapiens (Human) TR35110_c0_g1_i2 Q9ATL4 TIP43_MAIZE 1.00E-33 GO:0016021; GO:0005215; GO:0005774 integral to membrane; transporter activity; vacuolar membrane IPR023271; IPR000425; IPR022357; Aquaporin TIP4-3 (Tonoplast intrinsic protein 4-3) (ZmTIP4-3) (ZmTIP4;3) TIP4-3 Zea mays (Maize) TR35110_c0_g1_i3 O77750 AQP4_BOVIN 1.00E-79 GO:0071346; GO:0005737; GO:0009897; GO:0016021; GO:0050891; GO:0015250 cellular response to interferon-gamma; cytoplasm; external side of plasma membrane; integral to membrane; multicellular organismal water homeostasis; water channel activity IPR023271; IPR000425; IPR022357; Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4) AQP4 Bos taurus (Bovine) TR35112_c3_g1_i1 P0C6B8 SVEP1_RAT 3.00E-23 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) TR35112_c3_g1_i2 P78539 SRPX_HUMAN 3.00E-22 GO:0005776; GO:0006914; GO:0007155; GO:0009986; GO:0033554; GO:0005783; GO:0016020; GO:0060244; GO:0001845; GO:0043065 autophagic vacuole; autophagy; cell adhesion; cell surface; cellular response to stress; endoplasmic reticulum; membrane; negative regulation of cell proliferation involved in contact inhibition; phagolysosome assembly; positive regulation of apoptotic process IPR025232; IPR003410; IPR000436; Sushi repeat-containing protein SRPX SRPX ETX1 Homo sapiens (Human) TR35112_c3_g1_i3 Q2PZL6 FAT4_MOUSE 6.00E-16 GO:0045177; GO:0001658; GO:0005509; GO:0048565; GO:0001736; GO:0003007; GO:0007156; GO:0060122; GO:0016021; GO:0001822; GO:0043931; GO:0005886; GO:0007009 apical part of cell; branching involved in ureteric bud morphogenesis; calcium ion binding; digestive tract development; establishment of planar polarity; heart morphogenesis; homophilic cell adhesion; inner ear receptor stereocilium organization; integral to membrane; kidney development; ossification involved in bone maturation; plasma membrane; plasma membrane organization IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) Fat4 Fatj Mus musculus (Mouse) TR35112_c3_g1_i4 Q9R172 NOTC3_RAT 1.00E-14 GO:0007219; GO:0005509; GO:0030154; GO:0016021; GO:0007275; GO:0005634; GO:0005886; GO:0050793; GO:0006355; GO:0042246; GO:0006351 "Notch signaling pathway; calcium ion binding; cell differentiation; integral to membrane; multicellular organismal development; nucleus; plasma membrane; regulation of developmental process; regulation of transcription, DNA-dependent; tissue regeneration; transcription, DNA-dependent" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022331; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] Notch3 Rattus norvegicus (Rat) TR35112_c3_g1_i6 P0C6B8 SVEP1_RAT 2.00E-23 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) TR35115_c0_g1_i2 Q6R7D0 IAP3_OSHVF 2.00E-10 IPR001370; Putative apoptosis inhibitor ORF99 ORF99 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) TR35115_c0_g1_i3 O62640 PIAP_PIG 4.00E-35 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR35115_c0_g1_i4 Q8JHV9 BIR7A_XENLA 5.00E-39 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR35117_c1_g2_i1 Q5H7C0 CDC20_PIG 4.00E-167 GO:0051488; GO:0005680; GO:0031145; GO:0051301; GO:0005737; GO:0005815; GO:0007067; GO:0090129; GO:0031915; GO:0016567; GO:0040020; GO:0000922 activation of anaphase-promoting complex activity; anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; cytoplasm; microtubule organizing center; mitosis; positive regulation of synapse maturation; positive regulation of synaptic plasticity; protein ubiquitination; regulation of meiosis; spindle pole IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. Cell division cycle protein 20 homolog (p55CDC) CDC20 Sus scrofa (Pig) TR35118_c0_g1_i2 Q700K0 SSPO_RAT 3.00E-30 GO:0007155; GO:0005615 cell adhesion; extracellular space IPR000421; IPR006207; IPR008979; IPR023415; IPR002172; IPR000884; IPR002919; IPR014853; IPR006552; IPR001007; IPR001846; SCO-spondin Sspo Rattus norvegicus (Rat) TR35118_c0_g2_i1 Q2PC93 SSPO_CHICK 6.00E-11 GO:0007155; GO:0005615 cell adhesion; extracellular space IPR000421; IPR006207; IPR008979; IPR023415; IPR002172; IPR000884; IPR002919; IPR014853; IPR001007; IPR001846; SCO-spondin SSPO Gallus gallus (Chicken) TR35119_c0_g1_i1 Q04432 HSP31_YEAST 2.00E-30 GO:0008234; GO:0006508; GO:0006950; GO:0051082 cysteine-type peptidase activity; proteolysis; response to stress; unfolded protein binding IPR002818; Probable chaperone protein HSP31 (EC 3.2.-.-) (Heat shock protein 31) HSP31 YDR533C D9719.36 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR35119_c0_g2_i2 Q09675 YA02_SCHPO 2.00E-26 GO:0034599; GO:0005829; GO:0005634; GO:0008233; GO:0006508 cellular response to oxidative stress; cytosol; nucleus; peptidase activity; proteolysis IPR002818; Uncharacterized protein C5H10.02c (EC 3.2.-.-) SPAC5H10.02c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR35119_c0_g2_i5 O43084 YHS9_SCHPO 1.00E-27 GO:0034599; GO:0008233; GO:0006508 cellular response to oxidative stress; peptidase activity; proteolysis IPR002818; Uncharacterized protein C947.09 (EC 3.2.-.-) SPBC947.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR35120_c1_g2_i2 Q08DY9 CASP3_BOVIN 3.00E-29 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Bos taurus (Bovine) TR35122_c1_g1_i1 Q9NZQ8 TRPM5_HUMAN 2.00E-18 GO:0005227; GO:0016021; GO:0005216; GO:0005886; GO:0005267; GO:0005272; GO:0005244 calcium activated cation channel activity; integral to membrane; ion channel activity; plasma membrane; potassium channel activity; sodium channel activity; voltage-gated ion channel activity Transient receptor potential cation channel subfamily M member 5 (Long transient receptor potential channel 5) (LTrpC-5) (LTrpC5) (MLSN1- and TRP-related gene 1 protein) TRPM5 LTRPC5 MTR1 Homo sapiens (Human) TR35123_c0_g1_i1 O08523 TECTA_MOUSE 9.00E-21 GO:0031225; GO:0007160; GO:0005201; GO:0005886; GO:0005578; GO:0007605 anchored to membrane; cell-matrix adhesion; extracellular matrix structural constituent; plasma membrane; proteinaceous extracellular matrix; sensory perception of sound IPR000742; IPR003886; IPR002919; IPR025615; IPR014853; IPR006552; IPR001007; IPR001846; IPR001507; IPR017977; Alpha-tectorin Tecta Mus musculus (Mouse) TR35123_c0_g1_i2 Q28983 ZAN_PIG 2.00E-31 GO:0007339; GO:0007155; GO:0050840; GO:0016021; GO:0005886 binding of sperm to zona pellucida; cell adhesion; extracellular matrix binding; integral to membrane; plasma membrane IPR008985; IPR000742; IPR013032; IPR000998; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; Zonadhesin ZAN Sus scrofa (Pig) TR35124_c0_g1_i1 Q5PQ50 NUD19_XENLA 2.00E-80 GO:0016787; GO:0046872; GO:0005739; GO:0005777 hydrolase activity; metal ion binding; mitochondrion; peroxisome IPR000086; IPR015797; "Nucleoside diphosphate-linked moiety X motif 19, mitochondrial (Nudix motif 19) (EC 3.6.1.-)" nudt19 Xenopus laevis (African clawed frog) TR35125_c0_g1_i1 Q568W0 SELW_DANRE 2.00E-28 GO:0016209; GO:0045454; GO:0005737; GO:0008430 antioxidant activity; cell redox homeostasis; cytoplasm; selenium binding IPR011893; IPR012336; Selenoprotein W (SelW) sepw1 Danio rerio (Zebrafish) (Brachydanio rerio) TR35125_c0_g1_i4 Q568W0 SELW_DANRE 3.00E-31 GO:0016209; GO:0045454; GO:0005737; GO:0008430 antioxidant activity; cell redox homeostasis; cytoplasm; selenium binding IPR011893; IPR012336; Selenoprotein W (SelW) sepw1 Danio rerio (Zebrafish) (Brachydanio rerio) TR35125_c0_g1_i5 P63301 SELW_RAT 6.00E-27 GO:0016209; GO:0045454; GO:0005737; GO:0010269; GO:0008430 antioxidant activity; cell redox homeostasis; cytoplasm; response to selenium ion; selenium binding IPR011893; IPR012336; Selenoprotein W (SelW) Sepw1 Selw Rattus norvegicus (Rat) TR35126_c5_g1_i1 P33215 NEDD1_MOUSE 2.00E-84 GO:0045177; GO:0051301; GO:0005814; GO:0000924; GO:0005932; GO:0007019; GO:0007067; GO:0070201; GO:0000922 "apical part of cell; cell division; centriole; gamma-tubulin ring complex, centrosomal; microtubule basal body; microtubule depolymerization; mitosis; regulation of establishment of protein localization; spindle pole" IPR015943; IPR001680; IPR019775; IPR017986; Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) Nedd1 Nedd-1 Mus musculus (Mouse) TR35127_c2_g1_i1 Q6PBN2 AIDA_DANRE 1.00E-83 GO:0048264; GO:0046329; GO:0043508; GO:2000016; GO:0043496 determination of ventral identity; negative regulation of JNK cascade; negative regulation of JUN kinase activity; negative regulation of determination of dorsal identity; regulation of protein homodimerization activity IPR025939; IPR023421; "Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist)" aida zgc:73327 Danio rerio (Zebrafish) (Brachydanio rerio) TR35129_c4_g1_i1 P52168 PNR_DROME 4.00E-50 GO:0000983; GO:0007350; GO:0007510; GO:0008407; GO:0007391; GO:0007398; GO:0035050; GO:0060047; GO:0048542; GO:0000122; GO:0005634; GO:0061320; GO:0042440; GO:0045944; GO:0002805; GO:0043565; GO:0007179; GO:0008270 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; blastoderm segmentation; cardioblast cell fate determination; chaeta morphogenesis; dorsal closure; ectoderm development; embryonic heart tube development; heart contraction; lymph gland development; negative regulation of transcription from RNA polymerase II promoter; nucleus; pericardial nephrocyte differentiation; pigment metabolic process; positive regulation of transcription from RNA polymerase II promoter; regulation of antimicrobial peptide biosynthetic process; sequence-specific DNA binding; transforming growth factor beta receptor signaling pathway; zinc ion binding IPR000679; IPR013088; GATA-binding factor A (Protein pannier) (Transcription factor GATA-A) (dGATA-A) pnr GATA-A CG3978 Drosophila melanogaster (Fruit fly) TR3513_c0_g1_i1 Q9ET30 TM9S3_MOUSE 8.00E-32 GO:0016021 integral to membrane IPR004240; Transmembrane 9 superfamily member 3 Tm9sf3 Smbp Mus musculus (Mouse) TR35130_c0_g1_i1 Q5XIY2 TM56B_DANRE 2.00E-50 GO:0016021 integral to membrane IPR006634; Transmembrane protein 56-B tmem56b tmem56 zgc:92864 Danio rerio (Zebrafish) (Brachydanio rerio) TR35130_c0_g1_i2 Q6GLX2 TM56A_XENLA 2.00E-43 GO:0016021 integral to membrane IPR006634; Transmembrane protein 56-A tmem56-a Xenopus laevis (African clawed frog) TR35130_c0_g1_i3 Q8CGF5 TMM56_MOUSE 8.00E-51 GO:0016021 integral to membrane IPR006634; Transmembrane protein 56 Tmem56 Mus musculus (Mouse) TR35130_c0_g1_i4 Q5XIY2 TM56B_DANRE 3.00E-50 GO:0016021 integral to membrane IPR006634; Transmembrane protein 56-B tmem56b tmem56 zgc:92864 Danio rerio (Zebrafish) (Brachydanio rerio) TR35130_c0_g1_i6 Q6GLX2 TM56A_XENLA 8.00E-43 GO:0016021 integral to membrane IPR006634; Transmembrane protein 56-A tmem56-a Xenopus laevis (African clawed frog) TR35130_c0_g1_i7 Q71RH2 FA57B_HUMAN 1.00E-05 GO:0000139; GO:0005783; GO:0005789; GO:0016021; GO:0006629 Golgi membrane; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; lipid metabolic process IPR006634; Protein FAM57B FAM57B FP1188 Homo sapiens (Human) TR35130_c0_g1_i9 Q7TNV1 FA57B_MOUSE 6.00E-06 GO:0000139; GO:0005789; GO:0016021; GO:0006629 Golgi membrane; endoplasmic reticulum membrane; integral to membrane; lipid metabolic process IPR006634; Protein FAM57B Fam57b Mus musculus (Mouse) TR35134_c0_g1_i1 B0V5X4 UBIG_ACIBY 5.00E-12 GO:0008425; GO:0008689; GO:0006744 "2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; 3-demethylubiquinone-9 3-O-methyltransferase activity; ubiquinone biosynthetic process" IPR010233; Cofactor biosynthesis; ubiquinone biosynthesis. Ubiquinone biosynthesis O-methyltransferase (2-polyprenyl-6-hydroxyphenol methylase) (EC 2.1.1.222) (3-demethylubiquinone 3-O-methyltransferase) (EC 2.1.1.64) ubiG ABAYE3834 Acinetobacter baumannii (strain AYE) TR35135_c1_g1_i1 Q9W3C2 GSCR2_DROME 4.00E-09 GO:0022008 Q9VLS5 neurogenesis IPR011211; IPR011687; Uncharacterized protein CG1785 CG1785 Drosophila melanogaster (Fruit fly) TR35135_c1_g2_i1 Q9NZM5 GSCR2_HUMAN 8.00E-18 GO:0005730 nucleolus IPR011211; IPR011687; Glioma tumor suppressor candidate region gene 2 protein (p60) GLTSCR2 Homo sapiens (Human) TR35137_c4_g1_i1 P56701 PSMD2_BOVIN 0 GO:0030234; GO:0022624; GO:0050790; GO:0042176 enzyme regulator activity; proteasome accessory complex; regulation of catalytic activity; regulation of protein catabolic process IPR016643; IPR016024; IPR002015; 26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Tumor necrosis factor type 1 receptor-associated protein 2) PSMD2 TRAP2 Bos taurus (Bovine) TR35137_c6_g1_i1 O95149 SPN1_HUMAN 3.00E-98 GO:0000339; GO:0005829; GO:0034660; GO:0005643; GO:0006606; GO:0008565; GO:0061015; GO:0000387 RNA cap binding; cytosol; ncRNA metabolic process; nuclear pore; protein import into nucleus; protein transporter activity; snRNA import into nucleus; spliceosomal snRNP assembly IPR002652; IPR017336; IPR024721; Snurportin-1 (RNA U transporter 1) SNUPN RNUT1 SPN1 Homo sapiens (Human) TR35137_c6_g1_i2 O95149 SPN1_HUMAN 6.00E-101 GO:0000339; GO:0005829; GO:0034660; GO:0005643; GO:0006606; GO:0008565; GO:0061015; GO:0000387 RNA cap binding; cytosol; ncRNA metabolic process; nuclear pore; protein import into nucleus; protein transporter activity; snRNA import into nucleus; spliceosomal snRNP assembly IPR002652; IPR017336; IPR024721; Snurportin-1 (RNA U transporter 1) SNUPN RNUT1 SPN1 Homo sapiens (Human) TR35139_c0_g1_i1 Q8KWT4 BACC2_BACIU 3.00E-15 GO:0017000; GO:0016491 antibiotic biosynthetic process; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Antibiotic biosynthesis; bacilysin biosynthesis. Bacilysin biosynthesis oxidoreductase BacC (EC 1.-.-.-) bacC Bacillus subtilis TR35139_c0_g1_i2 A6NNS2 DRS7C_HUMAN 3.00E-06 GO:0005576; GO:0014801; GO:0010880; GO:0004745; GO:0033017 extracellular region; longitudinal sarcoplasmic reticulum; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; retinol dehydrogenase activity; sarcoplasmic reticulum membrane IPR002198; IPR002347; IPR016040; IPR020904; Dehydrogenase/reductase SDR family member 7C (EC 1.1.-.-) DHRS7C Homo sapiens (Human) TR35139_c0_g1_i3 P50170 RDH2_RAT 3.00E-67 GO:0005783; GO:0042573; GO:0004745; GO:0042572 endoplasmic reticulum; retinoic acid metabolic process; retinol dehydrogenase activity; retinol metabolic process IPR002198; IPR002347; IPR016040; IPR020904; Cofactor metabolism; retinol metabolism. Retinol dehydrogenase 2 (EC 1.1.1.105) (29 kDa protein) (Retinol dehydrogenase type II) (RODH II) Rdh2 Rodhii Rattus norvegicus (Rat) TR35143_c1_g1_i1 Q96DM1 PGBD4_HUMAN 2.00E-13 PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) TR35143_c4_g4_i1 Q08DY9 CASP3_BOVIN 4.00E-12 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Bos taurus (Bovine) TR35144_c1_g2_i2 P50226 ST1A2_HUMAN 9.00E-19 GO:0050427; GO:0009309; GO:0004062; GO:0006584; GO:0005829; GO:0047894; GO:0018958; GO:0008202; GO:0051923; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; amine biosynthetic process; aryl sulfotransferase activity; catecholamine metabolic process; cytosol; flavonol 3-sulfotransferase activity; phenol-containing compound metabolic process; steroid metabolic process; sulfation; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase 1A2 (ST1A2) (EC 2.8.2.1) (Aryl sulfotransferase 2) (Phenol sulfotransferase 2) (Phenol-sulfating phenol sulfotransferase 2) (P-PST 2) SULT1A2 STP2 Homo sapiens (Human) TR35144_c1_g2_i4 O43704 ST1B1_HUMAN 7.00E-51 GO:0050427; GO:0004062; GO:0006576; GO:0005829; GO:0009812; GO:0008202; GO:0051923; GO:0008146; GO:0042403; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; aryl sulfotransferase activity; cellular biogenic amine metabolic process; cytosol; flavonoid metabolic process; steroid metabolic process; sulfation; sulfotransferase activity; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) (Sulfotransferase 1B2) (ST1B2) (Thyroid hormone sulfotransferase) SULT1B1 ST1B2 SULT1B2 Homo sapiens (Human) TR35146_c1_g1_i2 Q568K2 PP1RB_DANRE 2.00E-14 GO:0004864 protein phosphatase inhibitor activity IPR011107; Protein phosphatase 1 regulatory subunit 11 ppp1r11 zgc:110245 Danio rerio (Zebrafish) (Brachydanio rerio) TR35146_c1_g1_i5 Q568K2 PP1RB_DANRE 2.00E-14 GO:0004864 protein phosphatase inhibitor activity IPR011107; Protein phosphatase 1 regulatory subunit 11 ppp1r11 zgc:110245 Danio rerio (Zebrafish) (Brachydanio rerio) TR35147_c2_g5_i1 A8WGS4 TLCD2_DANRE 1.00E-15 GO:0016021 integral to membrane IPR006634; TLC domain-containing protein 2 tlcd2 zgc:175098 Danio rerio (Zebrafish) (Brachydanio rerio) TR35149_c0_g1_i1 Q5ZKF4 HM20A_CHICK 2.00E-54 GO:0003677; GO:0005634; GO:0006355; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009071; High mobility group protein 20A (HMG box-containing protein 20A) HMG20A RCJMB04_11c24 Gallus gallus (Chicken) TR35149_c0_g2_i1 Q75B82 NHP6_ASHGO 3.00E-17 GO:0008301; GO:0006281; GO:0034724; GO:0032301; GO:0051123; GO:0070898; GO:0006338; GO:0005694; GO:0006355; GO:0043565 "DNA binding, bending; DNA repair; DNA replication-independent nucleosome organization; MutSalpha complex; RNA polymerase II transcriptional preinitiation complex assembly; RNA polymerase III transcriptional preinitiation complex assembly; chromatin remodeling; chromosome; regulation of transcription, DNA-dependent; sequence-specific DNA binding" IPR009071; Non-histone chromosomal protein 6 NHP6 ADL310W Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR35151_c0_g2_i1 Q9PTW9 PSA7_CARAU 6.00E-140 GO:0005737; GO:0005634; GO:0005839; GO:0019773; GO:0004298; GO:0006511 "cytoplasm; nucleus; proteasome core complex; proteasome core complex, alpha-subunit complex; threonine-type endopeptidase activity; ubiquitin-dependent protein catabolic process" IPR000426; IPR023332; IPR001353; Proteasome subunit alpha type-7 (EC 3.4.25.1) (Proteasome subunit alpha 4) psma7 Carassius auratus (Goldfish) TR35153_c0_g1_i1 Q9SA71 GLPT3_ARATH 3.00E-32 GO:0008643; GO:0016021; GO:0055062; GO:0055085; GO:0005215 carbohydrate transport; integral to membrane; phosphate ion homeostasis; transmembrane transport; transporter activity IPR011701; IPR020846; IPR016196; IPR000849; Putative glycerol-3-phosphate transporter 3 (G-3-P transporter 3) (Glycerol-3-phosphate permease 3) (AtG3Pp3) (G-3-P permease 3) At1g30560 T5I8.1 Arabidopsis thaliana (Mouse-ear cress) TR35155_c1_g1_i1 Q23023 UNC51_CAEEL 7.00E-92 GO:0005524; GO:0043277; GO:0006914; GO:0030424; GO:0007411; GO:0016477; GO:0040024; GO:0008340; GO:0009792; GO:0043025; GO:0012501; GO:0046777; GO:0004674; GO:0030516; GO:0040014; GO:0032880; GO:0045138 G5ECQ1; Q21441 ATP binding; apoptotic cell clearance; autophagy; axon; axon guidance; cell migration; dauer larval development; determination of adult lifespan; embryo development ending in birth or egg hatching; neuronal cell body; programmed cell death; protein autophosphorylation; protein serine/threonine kinase activity; regulation of axon extension; regulation of multicellular organism growth; regulation of protein localization; tail tip morphogenesis IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR022708; IPR017184; Serine/threonine-protein kinase unc-51 (EC 2.7.11.1) (Uncoordinated protein 51) unc-51 Y60A3A.1 Caenorhabditis elegans TR35157_c0_g1_i1 Q5RC11 RL11_PONAB 6.00E-103 GO:0005730; GO:0034504; GO:0019843; GO:0005840; GO:0003735; GO:0006412 nucleolus; protein localization to nucleus; rRNA binding; ribosome; structural constituent of ribosome; translation IPR002132; IPR020929; IPR022803; 60S ribosomal protein L11 RPL11 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35159_c3_g1_i2 P83425 HIP_MYTED 6.00E-06 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR35159_c3_g1_i3 Q9BXJ3 C1QT4_HUMAN 5.00E-06 GO:0005615 extracellular space IPR001073; IPR008983; Complement C1q tumor necrosis factor-related protein 4 C1QTNF4 CTRP4 Homo sapiens (Human) TR35160_c4_g2_i2 Q2HJF3 ORC6_BOVIN 8.00E-43 GO:0003677; GO:0006260; GO:0005664 DNA binding; DNA replication; nuclear origin of replication recognition complex IPR008721; IPR020529; Origin recognition complex subunit 6 ORC6 ORC6L Bos taurus (Bovine) TR35161_c1_g1_i2 Q5FWM8 GP180_XENLA 1.00E-82 GO:0007186; GO:0016021; GO:0019236 G-protein coupled receptor signaling pathway; integral to membrane; response to pheromone IPR019336; Integral membrane protein GPR180 gpr180 Xenopus laevis (African clawed frog) TR35163_c0_g1_i1 Q6DDL7 UN93A_XENLA 1.00E-124 GO:0016021 integral to membrane IPR010291; IPR016196; Protein unc-93 homolog A (Unc-93A) unc93a Xenopus laevis (African clawed frog) TR35163_c0_g1_i2 Q94AA1 UN933_ARATH 1.00E-24 GO:0016021 integral to membrane IPR010291; IPR016196; UNC93-like protein 3 At3g09470 F11F8.4 Arabidopsis thaliana (Mouse-ear cress) TR35164_c1_g2_i1 P26928 HGFL_MOUSE 2.00E-13 GO:0007566; GO:0005576; GO:0006508; GO:0004252 embryo implantation; extracellular region; proteolysis; serine-type endopeptidase activity IPR024174; IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR001254; IPR001314; IPR009003; Hepatocyte growth factor-like protein (Macrophage stimulatory protein) (MSP) [Cleaved into: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain] Mst1 Hgfl Mus musculus (Mouse) TR35164_c1_g2_i2 O18783 PLMN_MACEU 6.00E-24 GO:0007596; GO:0005576; GO:0042730; GO:0006508; GO:0004252; GO:0048771 blood coagulation; extracellular region; fibrinolysis; proteolysis; serine-type endopeptidase activity; tissue remodeling IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Macropus eugenii (Tammar wallaby) TR35164_c2_g1_i1 Q49LS4 XKR4_PANTR 1.00E-06 GO:0016021 integral to membrane IPR018629; XK-related protein 4 XKR4 XRG4 Pan troglodytes (Chimpanzee) TR35165_c5_g1_i1 Q5MYT7 OAS3_RAT 3.00E-15 GO:0001730; GO:0005524; GO:0005737; GO:0051607; GO:0003725; GO:0045087; GO:0046872; GO:0005634; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; cytoplasm; defense response to virus; double-stranded RNA binding; innate immune response; metal ion binding; nucleus; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) Oas3 Rattus norvegicus (Rat) TR35165_c8_g1_i1 P11928 OAS1A_MOUSE 2.00E-22 GO:0001730; GO:0005524; GO:0051607; GO:0003725; GO:0005783; GO:0045087; GO:0046872; GO:0005739; GO:0005634; GO:0006164; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; defense response to virus; double-stranded RNA binding; endoplasmic reticulum; innate immune response; metal ion binding; mitochondrion; nucleus; purine nucleotide biosynthetic process; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 1A ((2-5')oligo(A) synthase 1A) (2-5A synthase 1A) (EC 2.7.7.84) (p42 OAS) Oas1a Oias1 Mus musculus (Mouse) TR35165_c8_g1_i3 Q05961 OAS1A_RAT 1.00E-21 GO:0001730; GO:0005524; GO:0051607; GO:0003725; GO:0005783; GO:0045087; GO:0046872; GO:0005739; GO:0005634; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; defense response to virus; double-stranded RNA binding; endoplasmic reticulum; innate immune response; metal ion binding; mitochondrion; nucleus; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 1A ((2-5')oligo(A) synthase 1A) (2-5A synthase 1A) (EC 2.7.7.84) Oas1a Oas1 Rattus norvegicus (Rat) TR35165_c8_g1_i4 P11928 OAS1A_MOUSE 8.00E-23 GO:0001730; GO:0005524; GO:0051607; GO:0003725; GO:0005783; GO:0045087; GO:0046872; GO:0005739; GO:0005634; GO:0006164; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; defense response to virus; double-stranded RNA binding; endoplasmic reticulum; innate immune response; metal ion binding; mitochondrion; nucleus; purine nucleotide biosynthetic process; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 1A ((2-5')oligo(A) synthase 1A) (2-5A synthase 1A) (EC 2.7.7.84) (p42 OAS) Oas1a Oias1 Mus musculus (Mouse) TR35166_c0_g1_i3 Q8SPI2 CHCH7_MACFA 6.00E-13 GO:0005758 mitochondrial intermembrane space IPR009069; Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 CHCHD7 QnpA-16443 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR35169_c1_g1_i1 Q9UL03 INT6_HUMAN 0 GO:0015629; GO:0032039; GO:0016180; GO:0004888 P33993 actin cytoskeleton; integrator complex; snRNA processing; transmembrane signaling receptor activity IPR002035; Integrator complex subunit 6 (Int6) (DBI-1) (Protein DDX26) (Protein deleted in cancer 1) (DICE1) INTS6 DBI1 DDX26 DDX26A Homo sapiens (Human) TR35171_c1_g2_i2 P58028 AOFB_CAVPO 9.00E-06 GO:0016021; GO:0005741; GO:0016491 integral to membrane; mitochondrial outer membrane; oxidoreductase activity IPR002937; IPR001613; IPR016040; Amine oxidase [flavin-containing] B (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B) MAOB Cavia porcellus (Guinea pig) TR35171_c1_g3_i1 Q9NWM0 SMOX_HUMAN 8.00E-46 GO:0052895; GO:0005737; GO:0005829; GO:0052894; GO:0005634; GO:0006596; GO:0006598; GO:0046592; GO:0044281; GO:0046208; GO:0052901; GO:0006805 N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity; cytoplasm; cytosol; norspermine:oxygen oxidoreductase activity; nucleus; polyamine biosynthetic process; polyamine catabolic process; polyamine oxidase activity; small molecule metabolic process; spermine catabolic process; spermine:oxygen oxidoreductase (spermidine-forming) activity; xenobiotic metabolic process IPR002937; Amine and polyamine degradation; spermine degradation. Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1) SMOX C20orf16 SMO UNQ3039/PRO9854 Homo sapiens (Human) TR35172_c1_g2_i2 Q91V37 VATO_MOUSE 3.00E-56 GO:0015991; GO:0005768; GO:0008553; GO:0016021; GO:0033179; GO:0016471 "ATP hydrolysis coupled proton transport; endosome; hydrogen-exporting ATPase activity, phosphorylative mechanism; integral to membrane; proton-transporting V-type ATPase, V0 domain; vacuolar proton-transporting V-type ATPase complex" IPR002379; IPR000245; V-type proton ATPase 21 kDa proteolipid subunit (V-ATPase 21 kDa proteolipid subunit) (23 kDa subunit of V-ATPase) (Vacuolar proton pump 21 kDa proteolipid subunit) Atp6v0b Atp6f Mus musculus (Mouse) TR35173_c4_g1_i3 B5X337 GP183_SALSA 8.00E-06 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR000276; IPR017452; G-protein coupled receptor 183 gpr183 Salmo salar (Atlantic salmon) TR35176_c3_g2_i1 Q9GLY5 ITIH3_RABIT 1.00E-07 GO:0005576; GO:0030212; GO:0004867 extracellular region; hyaluronan metabolic process; serine-type endopeptidase inhibitor activity IPR010600; IPR013694; IPR002035; Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) ITIH3 Oryctolagus cuniculus (Rabbit) TR35180_c1_g2_i2 Q4P9K9 CHS8_USTMA 1.00E-13 GO:0005524; GO:0003677; GO:0004100; GO:0030659; GO:0020037; GO:0016021; GO:0003774; GO:0016459; GO:0005886 ATP binding; DNA binding; chitin synthase activity; cytoplasmic vesicle membrane; heme binding; integral to membrane; motor activity; myosin complex; plasma membrane IPR004835; IPR001199; IPR014876; IPR009057; IPR001609; IPR027417; Chitin synthase 8 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 8) (Myosin chitin synthase 1) CHS8 MCS1 UM03204 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR35180_c1_g2_i3 P78611 CHSD_EMENI 3.00E-14 GO:0003779; GO:0030476; GO:0043936; GO:0030428; GO:0009932; GO:0005935; GO:0071470; GO:0006031; GO:0004100; GO:0045009; GO:0048315; GO:0031505; GO:0020037; GO:0030448; GO:0001411; GO:0000131; GO:0016021; GO:0043332; GO:0005886; GO:0005628 actin binding; ascospore wall assembly; asexual sporulation resulting in formation of a cellular spore; cell septum; cell tip growth; cellular bud neck; cellular response to osmotic stress; chitin biosynthetic process; chitin synthase activity; chitosome; conidium formation; fungal-type cell wall organization; heme binding; hyphal growth; hyphal tip; incipient cellular bud site; integral to membrane; mating projection tip; plasma membrane; prospore membrane IPR004835; IPR001199; Chitin synthase D (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase D) (Class-V chitin synthase D) chsD chsE AN1555 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR35181_c2_g1_i1 Q9LXW7 DCL3_ARATH 2.00E-07 GO:0005524; GO:0008026; GO:0003723; GO:0006396; GO:0006952; GO:0031047; GO:0046872; GO:0090305; GO:0005730; GO:0004525 ATP binding; ATP-dependent helicase activity; RNA binding; RNA processing; defense response; gene silencing by RNA; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleolus; ribonuclease III activity IPR011545; IPR014001; IPR001650; IPR027417; IPR003100; IPR000999; Endoribonuclease Dicer homolog 3 (EC 3.1.26.-) (Dicer-like protein 3) (AtDCL3) DCL3 At3g43920 T15B3.60 Arabidopsis thaliana (Mouse-ear cress) TR35181_c3_g1_i7 O95786 DDX58_HUMAN 1.00E-105 GO:0005524; GO:0008026; GO:0039529; GO:0015629; GO:0005829; GO:0009597; GO:0003690; GO:0003725; GO:0045087; GO:0019048; GO:0032480; GO:0002230; GO:0032727; GO:0032728; GO:0051091; GO:0042993; GO:0045944; GO:0030334; GO:0034344; GO:0043330; GO:0032587; GO:0003727; GO:0005923; GO:0008270 Itself; P04543; Q920D5; Q9NQC7; O00571; Q7Z434; P21699; P04487; Q96S55; Q6IUF9; Q6IVU5; Q6UY62; Q6UY71; Q7Z2W4; Q7Z2W4-2 ATP binding; ATP-dependent helicase activity; RIG-I signaling pathway; actin cytoskeleton; cytosol; detection of virus; double-stranded DNA binding; double-stranded RNA binding; innate immune response; modulation by virus of host morphology or physiology; negative regulation of type I interferon production; positive regulation of defense response to virus by host; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of cell migration; regulation of type III interferon production; response to exogenous dsRNA; ruffle membrane; single-stranded RNA binding; tight junction; zinc ion binding IPR003593; IPR011029; IPR011545; IPR014001; IPR001650; IPR027417; IPR021673; Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) DDX58 Homo sapiens (Human) TR35183_c0_g2_i1 P48974 V1BR_RAT 5.00E-13 GO:0007188; GO:0007204; GO:0042538; GO:0016021; GO:0017046; GO:0005886; GO:0045777; GO:0032849; GO:0014049; GO:0010460; GO:0042803; GO:0005000 adenylate cyclase-modulating G-protein coupled receptor signaling pathway; elevation of cytosolic calcium ion concentration; hyperosmotic salinity response; integral to membrane; peptide hormone binding; plasma membrane; positive regulation of blood pressure; positive regulation of cellular pH reduction; positive regulation of glutamate secretion; positive regulation of heart rate; protein homodimerization activity; vasopressin receptor activity IPR015076; IPR000276; IPR017452; IPR001817; IPR000628; Vasopressin V1b receptor (V1bR) (AVPR V1b) (AVPR V3) (Antidiuretic hormone receptor 1b) (Vasopressin V3 receptor) Avpr1b Rattus norvegicus (Rat) TR35184_c0_g1_i1 Q9BVK2 ALG8_HUMAN 0 GO:0000033; GO:0006488; GO:0005789; GO:0016021; GO:0043687; GO:0018279 "alpha-1,3-mannosyltransferase activity; dolichol-linked oligosaccharide biosynthetic process; endoplasmic reticulum membrane; integral to membrane; post-translational protein modification; protein N-linked glycosylation via asparagine" IPR004856; Protein modification; protein glycosylation. "Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.265) (Asparagine-linked glycosylation protein 8 homolog) (Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase)" ALG8 HUSSY-02 Homo sapiens (Human) TR35184_c0_g1_i2 Q10479 ALG8_SCHPO 1.00E-119 GO:0042283; GO:0005783; GO:0005789; GO:0016021; GO:0006490; GO:0006486 "dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; oligosaccharide-lipid intermediate biosynthetic process; protein glycosylation" IPR004856; Protein modification; protein glycosylation. "Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.265) (Asparagine-linked glycosylation protein 8) (Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase)" alg8 SPAC17C9.07 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR35184_c0_g1_i3 Q9W3V8 ALG8_DROME 2.00E-142 GO:0005789; GO:0016021; GO:0006486; GO:0016758 "endoplasmic reticulum membrane; integral to membrane; protein glycosylation; transferase activity, transferring hexosyl groups" IPR004856; Protein modification; protein glycosylation. "Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase) (EC 2.4.1.265) (Asparagine-linked glycosylation protein 8 homolog) (Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase)" CG4542 Drosophila melanogaster (Fruit fly) TR35184_c0_g1_i5 Q9BVK2 ALG8_HUMAN 0 GO:0000033; GO:0006488; GO:0005789; GO:0016021; GO:0043687; GO:0018279 "alpha-1,3-mannosyltransferase activity; dolichol-linked oligosaccharide biosynthetic process; endoplasmic reticulum membrane; integral to membrane; post-translational protein modification; protein N-linked glycosylation via asparagine" IPR004856; Protein modification; protein glycosylation. "Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.265) (Asparagine-linked glycosylation protein 8 homolog) (Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase)" ALG8 HUSSY-02 Homo sapiens (Human) TR35186_c1_g1_i6 Q52828 GSTA_RHILE 5.00E-08 GO:0016740 transferase activity IPR010987; IPR004045; IPR012336; Protein GstA gstA Rhizobium leguminosarum TR35186_c1_g1_i7 O15247 CLIC2_HUMAN 1.00E-27 GO:0005254; GO:0034707; GO:0005737; GO:0004602; GO:0060315; GO:0005634; GO:0051099; GO:0010881; GO:0005247 chloride channel activity; chloride channel complex; cytoplasm; glutathione peroxidase activity; negative regulation of ryanodine-sensitive calcium-release channel activity; nucleus; positive regulation of binding; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; voltage-gated chloride channel activity IPR010987; IPR004045; IPR002946; IPR012336; Chloride intracellular channel protein 2 (XAP121) CLIC2 Homo sapiens (Human) TR35188_c1_g1_i1 P08012 PRP1_SOYBN 3.00E-09 GO:0005618; GO:0005576; GO:0007275; GO:0005199 cell wall; extracellular region; multicellular organismal development; structural constituent of cell wall IPR002964; IPR003883; Repetitive proline-rich cell wall protein 1 PRP1 Glycine max (Soybean) (Glycine hispida) TR35190_c1_g2_i1 Q8AYG3 TTK_DANRE 1.00E-87 GO:0005524; GO:0051301; GO:0009790; GO:0046872; GO:0007093; GO:0018108; GO:0004674; GO:0004712; GO:0004713; GO:0042246 ATP binding; cell division; embryo development; metal ion binding; mitotic cell cycle checkpoint; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; tissue regeneration IPR027084; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR011990; Dual specificity protein kinase Ttk (EC 2.7.12.1) (Mitotic checkpoint serine/threonine-protein kinase Mps1) (Monopolar spindle protein 1) (Protein nightcap) ttk mps1 ncp Danio rerio (Zebrafish) (Brachydanio rerio) TR35191_c5_g1_i3 P12270 TPR_HUMAN 1.00E-20 GO:0005524; GO:0000189; GO:0006404; GO:0005975; GO:0051301; GO:0035457; GO:0003682; GO:0019221; GO:0005868; GO:0070840; GO:0019898; GO:0015758; GO:0031072; GO:0000776; GO:0003729; GO:0031990; GO:0051019; GO:0007067; GO:0007077; GO:0072686; GO:0007094; GO:0046832; GO:0000122; GO:0045947; GO:0042405; GO:0031965; GO:0034399; GO:0044615; GO:0006999; GO:0005487; GO:0005654; GO:0031453; GO:0090267; GO:0046827; GO:0042307; GO:0042803; GO:0010827; GO:0010965; GO:1901673; GO:0070849; GO:0004828; GO:0006434; GO:0044281; GO:0055085; GO:0015631; GO:0016032 ATP binding; MAPK import into nucleus; RNA import into nucleus; carbohydrate metabolic process; cell division; cellular response to interferon-alpha; chromatin binding; cytokine-mediated signaling pathway; cytoplasmic dynein complex; dynein complex binding; extrinsic to membrane; glucose transport; heat shock protein binding; kinetochore; mRNA binding; mRNA export from nucleus in response to heat stress; mitogen-activated protein kinase binding; mitosis; mitotic nuclear envelope disassembly; mitotic spindle; mitotic spindle assembly checkpoint; negative regulation of RNA export from nucleus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of translational initiation; nuclear inclusion body; nuclear membrane; nuclear periphery; nuclear pore nuclear basket; nuclear pore organization; nucleocytoplasmic transporter activity; nucleoplasm; positive regulation of heterochromatin assembly; positive regulation of mitotic cell cycle spindle assembly checkpoint; positive regulation of protein export from nucleus; positive regulation of protein import into nucleus; protein homodimerization activity; regulation of glucose transport; regulation of mitotic sister chromatid separation; regulation of spindle assembly involved in mitosis; response to epidermal growth factor stimulus; serine-tRNA ligase activity; seryl-tRNA aminoacylation; small molecule metabolic process; transmembrane transport; tubulin binding; viral process IPR015866; IPR012929; Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) TPR Homo sapiens (Human) TR35195_c2_g1_i1 P06876 MYB_MOUSE 2.00E-79 GO:0030183; GO:0003677; GO:0000082; GO:0006816; GO:0003682; GO:0048566; GO:0048872; GO:0001701; GO:0005654; GO:0045944; GO:0003700; GO:0048538; GO:0006351 Q9QZR5 "B cell differentiation; DNA binding; G1/S transition of mitotic cell cycle; calcium ion transport; chromatin binding; embryonic digestive tract development; homeostasis of number of cells; in utero embryonic development; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; thymus development; transcription, DNA-dependent" IPR015395; IPR009057; IPR017930; IPR001005; IPR012642; Transcriptional activator Myb (Proto-oncogene c-Myb) Myb Mus musculus (Mouse) TR35197_c0_g2_i1 A7E2M3 EMC10_DANRE 4.00E-35 GO:0072546 ER membrane protein complex ER membrane protein complex subunit 10 emc10 zgc:171980 Danio rerio (Zebrafish) (Brachydanio rerio) TR35199_c1_g1_i2 Q6VUC1 DPH3_CRIGR 8.00E-20 GO:0005737; GO:0046872; GO:0050709; GO:0005634; GO:0017183; GO:0051099 cytoplasm; metal ion binding; negative regulation of protein secretion; nucleus; peptidyl-diphthamide biosynthetic process from peptidyl-histidine; positive regulation of binding IPR007872; Protein modification; peptidyl-diphthamide biosynthesis. DPH3 homolog (CSL-type zinc finger-containing protein 2) (Diphtheria toxin and Pseudomonas exotoxin A sensitivity-required protein 1) DPH3 DESR1 ZCSL2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR35199_c2_g2_i1 Q9HBL0 TENS1_HUMAN 2.00E-117 GO:0009986; GO:0007044; GO:0005737; GO:0005856; GO:0010761; GO:0005925 cell surface; cell-substrate junction assembly; cytoplasm; cytoskeleton; fibroblast migration; focal adhesion IPR000008; IPR011993; IPR014019; IPR013625; IPR006020; IPR000980; IPR014020; Tensin-1 TNS1 TNS Homo sapiens (Human) TR35199_c2_g2_i4 Q9HBL0 TENS1_HUMAN 6.00E-115 GO:0009986; GO:0007044; GO:0005737; GO:0005856; GO:0010761; GO:0005925 cell surface; cell-substrate junction assembly; cytoplasm; cytoskeleton; fibroblast migration; focal adhesion IPR000008; IPR011993; IPR014019; IPR013625; IPR006020; IPR000980; IPR014020; Tensin-1 TNS1 TNS Homo sapiens (Human) TR35199_c2_g2_i6 Q54JL7 CNRN_DICDI 9.00E-31 GO:0031152; GO:0030835; GO:0030818; GO:0035335; GO:0016791; GO:0016314; GO:0004725; GO:0008138; GO:0014066 "aggregation involved in sorocarp development; negative regulation of actin filament depolymerization; negative regulation of cAMP biosynthetic process; peptidyl-tyrosine dephosphorylation; phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; regulation of phosphatidylinositol 3-kinase cascade" IPR000340; IPR014019; IPR014020; IPR016130; "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase cnrN (EC 3.1.3.67)" cnrN DDB_G0287969 Dictyostelium discoideum (Slime mold) TR35200_c3_g1_i1 O48741 PORC_ARATH 4.00E-21 GO:0003959; GO:0015995; GO:0009941; GO:0031969; GO:0009535; GO:0015979; GO:0016630 NADPH dehydrogenase activity; chlorophyll biosynthetic process; chloroplast envelope; chloroplast membrane; chloroplast thylakoid membrane; photosynthesis; protochlorophyllide reductase activity IPR002198; IPR002347; IPR016040; IPR005979; Porphyrin-containing compound metabolism; chlorophyll biosynthesis. "Protochlorophyllide reductase C, chloroplastic (PCR C) (EC 1.3.1.33) (NADPH-protochlorophyllide oxidoreductase C) (POR C)" PORC At1g03630 F21B7.24 F21B7.35 F21B7_11 Arabidopsis thaliana (Mouse-ear cress) TR35200_c3_g1_i2 Q9QYF1 RDH11_MOUSE 5.00E-80 GO:0052650; GO:0016062; GO:0005789; GO:0016021; GO:0005622; GO:0001917; GO:0042574; GO:0004745 NADP-retinol dehydrogenase activity; adaptation of rhodopsin mediated signaling; endoplasmic reticulum membrane; integral to membrane; intracellular; photoreceptor inner segment; retinal metabolic process; retinol dehydrogenase activity IPR002198; IPR002347; IPR016040; Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (Cell line MC/9.IL4-derived protein 1) (M42C60) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short-chain aldehyde dehydrogenase) (SCALD) Rdh11 Arsdr1 Mdt1 Psdr1 Mus musculus (Mouse) TR35200_c3_g1_i3 Q9QYF1 RDH11_MOUSE 8.00E-80 GO:0052650; GO:0016062; GO:0005789; GO:0016021; GO:0005622; GO:0001917; GO:0042574; GO:0004745 NADP-retinol dehydrogenase activity; adaptation of rhodopsin mediated signaling; endoplasmic reticulum membrane; integral to membrane; intracellular; photoreceptor inner segment; retinal metabolic process; retinol dehydrogenase activity IPR002198; IPR002347; IPR016040; Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (Cell line MC/9.IL4-derived protein 1) (M42C60) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short-chain aldehyde dehydrogenase) (SCALD) Rdh11 Arsdr1 Mdt1 Psdr1 Mus musculus (Mouse) TR35200_c3_g1_i4 Q9HBH5 RDH14_HUMAN 3.00E-74 GO:0005783; GO:0005765; GO:0005739; GO:0016491 endoplasmic reticulum; lysosomal membrane; mitochondrion; oxidoreductase activity IPR002198; IPR002347; IPR016040; Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2) RDH14 PAN2 UNQ529/PRO1072 Homo sapiens (Human) TR35200_c3_g1_i5 Q8W3D9 PORB_ORYSJ 5.00E-15 GO:0015995; GO:0009507; GO:0015979; GO:0016630 chlorophyll biosynthetic process; chloroplast; photosynthesis; protochlorophyllide reductase activity IPR002198; IPR002347; IPR016040; IPR005979; Porphyrin-containing compound metabolism; chlorophyll biosynthesis. "Protochlorophyllide reductase B, chloroplastic (PCR B) (EC 1.3.1.33) (NADPH-protochlorophyllide oxidoreductase B) (POR B)" PORB Os10g0496900 LOC_Os10g35370 OSJNBa0017E08.8 Oryza sativa subsp. japonica (Rice) TR35200_c3_g1_i6 Q39617 POR_CHLRE 4.00E-13 GO:0015995; GO:0009507; GO:0015979; GO:0016630 chlorophyll biosynthetic process; chloroplast; photosynthesis; protochlorophyllide reductase activity IPR002198; IPR002347; IPR016040; IPR005979; Porphyrin-containing compound metabolism; chlorophyll biosynthesis. "Protochlorophyllide reductase, chloroplastic (PCR) (EC 1.3.1.33) (NADPH-protochlorophyllide oxidoreductase) (POR)" PORA LPCR-1 Chlamydomonas reinhardtii (Chlamydomonas smithii) TR35200_c3_g1_i7 P17611 NODG_AZOBR 4.00E-06 GO:0018454; GO:0005737; GO:0009877; GO:0042619 acetoacetyl-CoA reductase activity; cytoplasm; nodulation; poly-hydroxybutyrate biosynthetic process IPR011283; IPR002198; IPR002347; IPR016040; IPR020904; Nodulation protein G nodG Azospirillum brasilense TR35200_c3_g1_i8 P21218 PORB_ARATH 7.00E-13 GO:0015995; GO:0009941; GO:0009707; GO:0009535; GO:0015979; GO:0016630; GO:0009723 chlorophyll biosynthetic process; chloroplast envelope; chloroplast outer membrane; chloroplast thylakoid membrane; photosynthesis; protochlorophyllide reductase activity; response to ethylene stimulus IPR002198; IPR002347; IPR016040; IPR005979; Porphyrin-containing compound metabolism; chlorophyll biosynthesis. "Protochlorophyllide reductase B, chloroplastic (PCR B) (EC 1.3.1.33) (NADPH-protochlorophyllide oxidoreductase B) (POR B)" PORB At4g27440 F27G19.40 Arabidopsis thaliana (Mouse-ear cress) TR35201_c0_g1_i1 D3Z3C6 ZFAN4_MOUSE 1.00E-69 GO:0008270 zinc ion binding IPR019956; IPR000626; IPR000058; AN1-type zinc finger protein 4 (AN1-type zinc finger and ubiquitin domain-containing protein-like 1) Zfand4 Anubl1 Mus musculus (Mouse) TR35201_c0_g1_i2 D3Z3C6 ZFAN4_MOUSE 1.00E-69 GO:0008270 zinc ion binding IPR019956; IPR000626; IPR000058; AN1-type zinc finger protein 4 (AN1-type zinc finger and ubiquitin domain-containing protein-like 1) Zfand4 Anubl1 Mus musculus (Mouse) TR35202_c0_g1_i4 Q5M7F8 C070A_XENLA 3.00E-46 IPR018902; UPF0573 protein C2orf70 homolog A Xenopus laevis (African clawed frog) TR35202_c0_g1_i6 Q5M7F8 C070A_XENLA 3.00E-45 IPR018902; UPF0573 protein C2orf70 homolog A Xenopus laevis (African clawed frog) TR35203_c0_g1_i2 Q962X9 BUD31_BRABE 2.00E-91 GO:0005634 nucleus IPR018230; IPR001748; Protein BUD31 homolog (Protein G10 homolog) Branchiostoma belcheri (Amphioxus) TR35204_c3_g1_i3 O15315 RA51B_HUMAN 4.00E-79 GO:0005524; GO:0003677; GO:0006281; GO:0008094; GO:0007596; GO:0005654; GO:0007131 Q6NVH7 ATP binding; DNA binding; DNA repair; DNA-dependent ATPase activity; blood coagulation; nucleoplasm; reciprocal meiotic recombination IPR003593; IPR013632; IPR016467; IPR020588; IPR027417; DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (Rad51B) (RAD51-like protein 1) RAD51B RAD51L1 REC2 Homo sapiens (Human) TR35205_c4_g1_i1 Q8IT98 RS18_AEQIR 1.00E-81 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR027437; IPR001892; IPR010979; IPR018269; 40S ribosomal protein S18 RPS18 Argopecten irradians (Bay scallop) (Aequipecten irradians) TR35206_c0_g2_i1 Q6INU7 FRRS1_XENLA 1.00E-19 GO:0016021; GO:0016491 integral to membrane; oxidoreductase activity IPR006593; IPR005018; IPR002861; Putative ferric-chelate reductase 1 (EC 1.-.-.-) frrs1 Xenopus laevis (African clawed frog) TR35206_c0_g2_i2 Q0Q029 DFP1_ANTMY 7.00E-16 GO:0042742; GO:0042832; GO:0005576; GO:0045087 defense response to bacterium; defense response to protozoan; extracellular region; innate immune response IPR002861; Putative defense protein 1 (DFP-1) Antheraea mylitta (Tasar silkworm) TR35207_c3_g2_i1 Q3KR59 UBP10_RAT 4.00E-91 GO:0030330; GO:0006281; GO:0006914; GO:0004197; GO:0005769; GO:0045111; GO:0044325; GO:0005634; GO:0002039; GO:0016579; GO:0010506; GO:0004221; GO:0006511; GO:0004843 "DNA damage response, signal transduction by p53 class mediator; DNA repair; autophagy; cysteine-type endopeptidase activity; early endosome; intermediate filament cytoskeleton; ion channel binding; nucleus; p53 binding; protein deubiquitination; regulation of autophagy; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity" IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) Usp10 Rattus norvegicus (Rat) TR35208_c0_g3_i4 Q19417 YSNK_CAEEL 2.00E-06 GO:0016021 integral to membrane IPR008166; UPF0392 protein F13G3.3 F13G3.3 Caenorhabditis elegans TR35208_c1_g2_i2 P46778 RL21_HUMAN 7.00E-79 GO:0003723; GO:0006614; GO:0022625; GO:0000184; GO:0003735; GO:0006414; GO:0006413; GO:0006415; GO:0019083 "RNA binding; SRP-dependent cotranslational protein targeting to membrane; cytosolic large ribosomal subunit; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; translational elongation; translational initiation; translational termination; viral transcription" IPR001147; IPR018259; IPR008991; 60S ribosomal protein L21 RPL21 Homo sapiens (Human) TR35209_c1_g1_i2 Q1IN52 MUTS_KORVE 6.00E-69 GO:0005524; GO:0003684; GO:0006298; GO:0030983 ATP binding; damaged DNA binding; mismatch repair; mismatched DNA binding IPR005748; IPR007695; IPR000432; IPR007861; IPR007696; IPR016151; IPR007860; IPR027417; DNA mismatch repair protein MutS mutS Acid345_2697 Koribacter versatilis (strain Ellin345) TR35209_c1_g1_i3 P43246 MSH2_HUMAN 0 GO:0005524; GO:0030183; GO:0008094; GO:0032301; GO:0032302; GO:0000403; GO:0007050; GO:0019237; GO:0003684; GO:0008340; GO:0006302; GO:0000406; GO:0007281; GO:0032137; GO:0001701; GO:0031573; GO:0042771; GO:0045190; GO:0000404; GO:0043570; GO:0008584; GO:0006311; GO:0000710; GO:0043524; GO:0045128; GO:0000228; GO:0006119; GO:0051096; GO:0006301; GO:0042803; GO:0010224; GO:0010165; GO:0016446 P39875; P20585; P52701; Q8IY92 ATP binding; B cell differentiation; DNA-dependent ATPase activity; MutSalpha complex; MutSbeta complex; Y-form DNA binding; cell cycle arrest; centromeric DNA binding; damaged DNA binding; determination of adult lifespan; double-strand break repair; double-strand/single-strand DNA junction binding; germ cell development; guanine/thymine mispair binding; in utero embryonic development; intra-S DNA damage checkpoint; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; isotype switching; loop DNA binding; maintenance of DNA repeat elements; male gonad development; meiotic gene conversion; meiotic mismatch repair; negative regulation of neuron apoptotic process; negative regulation of reciprocal meiotic recombination; nuclear chromosome; oxidative phosphorylation; positive regulation of helicase activity; postreplication repair; protein homodimerization activity; response to UV-B; response to X-ray; somatic hypermutation of immunoglobulin genes IPR011184; IPR007695; IPR000432; IPR007861; IPR007696; IPR007860; IPR027417; DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2) MSH2 Homo sapiens (Human) TR35211_c0_g1_i1 Q13435 SF3B2_HUMAN 0 GO:0005689; GO:0071013; GO:0000398; GO:0019048; GO:0003676; GO:0005654 O60231; Q70Z53; O60341; O43395; Q6P2Q9; O15541; Q15427; O95391; Q01081; Q9HCS7; Q96NB3 "U12-type spliceosomal complex; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; modulation by virus of host morphology or physiology; nucleic acid binding; nucleoplasm" IPR007180; IPR006568; IPR003034; Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (SF3b150) (Spliceosome-associated protein 145) (SAP 145) SF3B2 SAP145 Homo sapiens (Human) TR35211_c0_g1_i4 Q13435 SF3B2_HUMAN 0 GO:0005689; GO:0071013; GO:0000398; GO:0019048; GO:0003676; GO:0005654 O60231; Q70Z53; O60341; O43395; Q6P2Q9; O15541; Q15427; O95391; Q01081; Q9HCS7; Q96NB3 "U12-type spliceosomal complex; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; modulation by virus of host morphology or physiology; nucleic acid binding; nucleoplasm" IPR007180; IPR006568; IPR003034; Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (SF3b150) (Spliceosome-associated protein 145) (SAP 145) SF3B2 SAP145 Homo sapiens (Human) TR35212_c2_g1_i1 Q7PD79 GNAS_ANOGA 1.00E-24 GO:0031683; GO:0001664; GO:0005525; GO:0003924; GO:0007191; GO:0005834; GO:0046872; GO:0007606; GO:0007608; GO:0004871 G-protein beta/gamma-subunit complex binding; G-protein coupled receptor binding; GTP binding; GTPase activity; adenylate cyclase-activating dopamine receptor signaling pathway; heterotrimeric G-protein complex; metal ion binding; sensory perception of chemical stimulus; sensory perception of smell; signal transducer activity IPR000367; IPR001019; IPR011025; IPR027417; Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) G-s-alpha-60A AGAP012095 Anopheles gambiae (African malaria mosquito) TR35213_c1_g1_i1 Q8BXB6 SO2B1_MOUSE 6.00E-66 GO:0016021; GO:0006811; GO:0005886; GO:0005215 integral to membrane; ion transport; plasma membrane; transporter activity IPR002350; IPR016196; IPR004156; Solute carrier organic anion transporter family member 2B1 (Solute carrier family 21 member 9) Slco2b1 Oatp2b1 Slc21a9 Mus musculus (Mouse) TR35213_c1_g1_i2 Q9JHI3 SO2B1_RAT 4.00E-11 GO:0016324; GO:0015125; GO:0016021; GO:0001889; GO:0071718; GO:0015347 apical plasma membrane; bile acid transmembrane transporter activity; integral to membrane; liver development; sodium-independent icosanoid transport; sodium-independent organic anion transmembrane transporter activity IPR002350; IPR016196; IPR004156; Solute carrier organic anion transporter family member 2B1 (Organic anion transporter moatp1) (Solute carrier family 21 member 9) Slco2b1 Oatp2b1 Slc21a9 Rattus norvegicus (Rat) TR35214_c2_g2_i1 Q8HY12 CLC4M_HYLLA 1.00E-14 GO:0006897; GO:0045087; GO:0016021; GO:0005537; GO:0046872 endocytosis; innate immune response; integral to membrane; mannose binding; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (CD antigen CD299) CLEC4M CD209L1 Hylobates lar (Common gibbon) (White-handed gibbon) TR35214_c2_g2_i4 P49300 CLC10_MOUSE 5.00E-13 GO:0030246; GO:0016021 carbohydrate binding; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR005640; C-type lectin domain family 10 member A (MMGL) (Macrophage asialoglycoprotein-binding protein 1) (M-ASGP-BP-1) (Macrophage galactose/N-acetylgalactosamine-specific lectin) Clec10a Mgl Mgl1 Mus musculus (Mouse) TR35214_c2_g2_i5 P86854 PLCL_MYTGA 2.00E-20 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR35214_c2_g2_i8 Q91ZW7 C209E_MOUSE 6.00E-14 GO:0006897; GO:0016021; GO:0005537 endocytosis; integral to membrane; mannose binding IPR001304; IPR016186; IPR018378; IPR016187; CD209 antigen-like protein E (DC-SIGN-related protein 4) (DC-SIGNR4) (CD antigen CD209) Cd209e Mus musculus (Mouse) TR35216_c0_g1_i1 P59326 YTHD1_MOUSE 1.00E-101 IPR007275; YTH domain family protein 1 (Dermatomyositis associated with cancer putative autoantigen 1 homolog) (DACA-1 homolog) Ythdf1 Mus musculus (Mouse) TR35216_c0_g1_i2 Q9Y5A9 YTHD2_HUMAN 2.00E-21 GO:0006959 humoral immune response IPR007275; YTH domain family protein 2 (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2) YTHDF2 HGRG8 Homo sapiens (Human) TR35217_c0_g2_i1 Q0VFZ6 CC173_HUMAN 1.00E-33 Coiled-coil domain-containing protein 173 CCDC173 C2orf77 Homo sapiens (Human) TR35218_c5_g1_i1 P46351 YTH1_PANTH 1.00E-13 GO:0016787 hydrolase activity IPR023214; IPR006357; IPR023215; IPR020476; IPR020084; IPR000086; IPR015797; Uncharacterized 45.4 kDa protein in thiaminase I 5'region Paenibacillus thiaminolyticus (Bacillus thiaminolyticus) TR35218_c5_g2_i1 Q5F4B1 PGP_CHICK 3.00E-33 GO:0005975; GO:0016311; GO:0008967 carbohydrate metabolic process; dephosphorylation; phosphoglycolate phosphatase activity IPR023214; IPR006357; IPR023215; IPR006349; Phosphoglycolate phosphatase (PGP) (PGPase) (EC 3.1.3.18) PGP RCJMB04_1e2 Gallus gallus (Chicken) TR35218_c5_g2_i3 A6NDG6 PGP_HUMAN 3.00E-42 GO:0005975; GO:0016311; GO:0008967 carbohydrate metabolic process; dephosphorylation; phosphoglycolate phosphatase activity IPR023214; IPR006357; IPR023215; IPR006349; Phosphoglycolate phosphatase (PGP) (PGPase) (EC 3.1.3.18) PGP Homo sapiens (Human) TR35219_c1_g1_i1 Q460N5 PAR14_HUMAN 1.00E-16 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR35219_c11_g1_i1 Q7Z2W4 ZCCHV_HUMAN 2.00E-06 GO:0005794; GO:0003950; GO:0003723; GO:0071360; GO:0005737; GO:0051607; GO:0045087; GO:0046872; GO:0045071; GO:0005634; GO:0005886; GO:0043123; GO:1900246; GO:0032727; GO:0032728; GO:0061014; GO:0032481; GO:0009615 O95786 Golgi apparatus; NAD+ ADP-ribosyltransferase activity; RNA binding; cellular response to exogenous dsRNA; cytoplasm; defense response to virus; innate immune response; metal ion binding; negative regulation of viral genome replication; nucleus; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of RIG-I signaling pathway; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of mRNA catabolic process; positive regulation of type I interferon production; response to virus IPR012317; IPR004170; IPR000571; Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) ZC3HAV1 ZC3HDC2 PRO1677 Homo sapiens (Human) TR35219_c14_g1_i1 Q02874 H2AY_RAT 4.00E-09 GO:0001740; GO:0003677; GO:0003682; GO:0016568; GO:0000793; GO:0007549; GO:0000786; GO:0006334 Barr body; DNA binding; chromatin binding; chromatin modification; condensed chromosome; dosage compensation; nucleosome; nucleosome assembly IPR021171; IPR009072; IPR007125; IPR002119; IPR002589; Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (H2A.y) (H2A/y) H2afy Rattus norvegicus (Rat) TR35219_c15_g1_i1 Q9WYX8 Y508_THEMA 3.00E-19 GO:0005524; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0009378 ATP binding; DNA binding; DNA recombination; DNA repair; DNA replication; four-way junction helicase activity IPR003593; IPR008824; IPR008921; IPR002589; IPR021886; IPR027417; Uncharacterized protein TM_0508 TM_0508 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR35219_c16_g1_i1 Q97UU4 Y2899_SULSO 2.00E-14 IPR002589; Uncharacterized protein SSO2899 SSO2899 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) TR35219_c8_g2_i1 Q460N3 PAR15_HUMAN 6.00E-20 GO:0003950; GO:0005634; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) TR35219_c8_g2_i2 Q460N5 PAR14_HUMAN 2.00E-19 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR35219_c9_g1_i1 Q2EMV9 PAR14_MOUSE 3.00E-23 GO:0003950; GO:0005737; GO:0003676; GO:0005634; GO:0005886; GO:0006355; GO:0006351 P06745 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleic acid binding; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR000504; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) TR3522_c0_g1_i1 A8DYE2 TRPCG_DROME 7.00E-09 GO:0005261; GO:0034703; GO:0016049; GO:0070838; GO:0010960; GO:0046873; GO:0007005; GO:0055069 cation channel activity; cation channel complex; cell growth; divalent metal ion transport; magnesium ion homeostasis; metal ion transmembrane transporter activity; mitochondrion organization; zinc ion homeostasis IPR005821; Transient receptor potential cation channel trpm trpm CG44240 Drosophila melanogaster (Fruit fly) TR35220_c4_g1_i1 Q640I9 KDM2B_XENLA 3.00E-52 GO:0003677; GO:0070544; GO:0051864; GO:0005730; GO:0019843; GO:0006355; GO:0006351; GO:0008270 "DNA binding; histone H3-K36 demethylation; histone demethylase activity (H3-K36 specific); nucleolus; rRNA binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001810; IPR003347; IPR002857; IPR011011; IPR001965; IPR019787; Lysine-specific demethylase 2B (EC 1.14.11.27) (F-box and leucine-rich repeat protein 10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) ([Histone-H3]-lysine-36 demethylase 1B) kdm2b fbxl10 jhdm1b Xenopus laevis (African clawed frog) TR35221_c0_g1_i1 P62752 RL23A_RAT 6.00E-62 GO:0008283; GO:0022625; GO:0000166; GO:0005634; GO:0019843; GO:0003735; GO:0006412 cell proliferation; cytosolic large ribosomal subunit; nucleotide binding; nucleus; rRNA binding; structural constituent of ribosome; translation IPR012677; IPR019985; IPR012678; IPR001014; IPR005633; IPR013025; 60S ribosomal protein L23a Rpl23a Rattus norvegicus (Rat) TR35222_c0_g1_i1 Q9D0A3 CO038_MOUSE 6.00E-43 IPR018889; Arpin (Arp2/3 inhibition protein) Arpin Mus musculus (Mouse) TR35222_c0_g1_i6 Q9D0A3 CO038_MOUSE 3.00E-43 IPR018889; Arpin (Arp2/3 inhibition protein) Arpin Mus musculus (Mouse) TR35224_c0_g1_i1 P03952 KLKB1_HUMAN 6.00E-50 GO:0002542; GO:0007597; GO:0022617; GO:0005615; GO:0042730; GO:0005886; GO:0031639; GO:0051919; GO:0006508; GO:0004252 "Factor XII activation; blood coagulation, intrinsic pathway; extracellular matrix disassembly; extracellular space; fibrinolysis; plasma membrane; plasminogen activation; positive regulation of fibrinolysis; proteolysis; serine-type endopeptidase activity" IPR000177; IPR003014; IPR003609; IPR001254; IPR018114; IPR001314; IPR009003; Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain] KLKB1 KLK3 Homo sapiens (Human) TR35224_c1_g1_i2 P0CN88 ALG13_CRYNJ 1.00E-18 GO:0004577; GO:0030246; GO:0005783; GO:0030259 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity; carbohydrate binding; endoplasmic reticulum; lipid glycosylation IPR007235; UDP-N-acetylglucosamine transferase subunit ALG13 (EC 2.4.1.141) (Asparagine-linked glycosylation protein 13) ALG13 CNB05490 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR35224_c1_g1_i3 Q5I0K7 ALG13_RAT 3.00E-52 GO:0004577; GO:0030246; GO:0005783; GO:0030259 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity; carbohydrate binding; endoplasmic reticulum; lipid glycosylation IPR007235; UDP-N-acetylglucosamine transferase subunit ALG13 homolog (EC 2.4.1.141) (Glycosyltransferase 28 domain-containing protein 1) Alg13 Glt28d1 Rattus norvegicus (Rat) TR35225_c3_g2_i1 P05090 APOD_HUMAN 6.00E-33 GO:0007568; GO:0001525; GO:0007420; GO:0015485; GO:0022626; GO:0030425; GO:0005783; GO:0005615; GO:0006006; GO:0006629; GO:0005319; GO:2000405; GO:1900016; GO:0051895; GO:0060588; GO:0071638; GO:0010642; GO:0042308; GO:0048662; GO:2000098; GO:0043025; GO:0048471; GO:0014012; GO:0042493; GO:0000302; GO:0042246 aging; angiogenesis; brain development; cholesterol binding; cytosolic ribosome; dendrite; endoplasmic reticulum; extracellular space; glucose metabolic process; lipid metabolic process; lipid transporter activity; negative regulation of T cell migration; negative regulation of cytokine production involved in inflammatory response; negative regulation of focal adhesion assembly; negative regulation of lipoprotein lipid oxidation; negative regulation of monocyte chemotactic protein-1 production; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein import into nucleus; negative regulation of smooth muscle cell proliferation; negative regulation of smooth muscle cell-matrix adhesion; neuronal cell body; perinuclear region of cytoplasm; peripheral nervous system axon regeneration; response to drug; response to reactive oxygen species; tissue regeneration IPR026222; IPR002969; IPR012674; IPR011038; IPR002345; IPR022271; IPR022272; IPR000566; Apolipoprotein D (Apo-D) (ApoD) APOD Homo sapiens (Human) TR35225_c3_g2_i3 Q8NCC3 PAG15_HUMAN 8.00E-106 GO:0008374; GO:0047499; GO:0006672; GO:0005576; GO:0009062; GO:0004622; GO:0005764; GO:0005739; GO:0046470; GO:0005543 O-acyltransferase activity; calcium-independent phospholipase A2 activity; ceramide metabolic process; extracellular region; fatty acid catabolic process; lysophospholipase activity; lysosome; mitochondrion; phosphatidylcholine metabolic process; phospholipid binding IPR003386; Group XV phospholipase A2 (EC 2.3.1.-) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) PLA2G15 LYPLA3 UNQ341/PRO540 Homo sapiens (Human) TR35229_c1_g3_i1 P49221 TGM4_HUMAN 1.00E-132 GO:0046872; GO:0018149; GO:0018184; GO:0003810 metal ion binding; peptide cross-linking; protein polyamination; protein-glutamine gamma-glutamyltransferase activity IPR023608; IPR013783; IPR014756; IPR002931; IPR008958; IPR013808; IPR001102; Protein-glutamine gamma-glutamyltransferase 4 (EC 2.3.2.13) (Fibrinoligase) (Prostate transglutaminase) (Prostate-specific transglutaminase) (Transglutaminase P) (TG(P)) (TGP) (TGase P) (Transglutaminase-4) (TGase-4) TGM4 Homo sapiens (Human) TR35230_c1_g1_i1 P10079 FBP1_STRPU 1.00E-14 GO:0032579; GO:0005509; GO:0016023; GO:0005615 apical lamina of hyaline layer; calcium ion binding; cytoplasmic membrane-bounded vesicle; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) TR35230_c1_g2_i1 Q5IS41 NCAN_PANTR 3.00E-15 GO:0005509; GO:0030246; GO:0007155; GO:0005576; GO:0005540 calcium ion binding; carbohydrate binding; cell adhesion; extracellular region; hyaluronic acid binding IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Neurocan core protein (Chondroitin sulfate proteoglycan 3) NCAN CSPG3 Pan troglodytes (Chimpanzee) TR35230_c2_g1_i3 P01267 THYG_BOVIN 3.00E-06 GO:0005615; GO:0042446; GO:0006590 extracellular space; hormone biosynthetic process; thyroid hormone generation IPR002018; IPR019819; IPR009030; IPR016324; IPR000716; IPR011641; Thyroglobulin (Tg) TG Bos taurus (Bovine) TR35231_c7_g1_i2 Q8CD54 PIEZ2_MOUSE 2.00E-161 GO:0005261; GO:0016021; GO:0008381; GO:0005886; GO:0042391 cation channel activity; integral to membrane; mechanically-gated ion channel activity; plasma membrane; regulation of membrane potential IPR027272; Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) Piezo2 Fam38b Mus musculus (Mouse) TR35231_c8_g1_i1 Q8CD54 PIEZ2_MOUSE 8.00E-54 GO:0005261; GO:0016021; GO:0008381; GO:0005886; GO:0042391 cation channel activity; integral to membrane; mechanically-gated ion channel activity; plasma membrane; regulation of membrane potential IPR027272; Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) Piezo2 Fam38b Mus musculus (Mouse) TR35234_c13_g1_i1 Q2R1Z5 CML6_ORYSJ 1.00E-09 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Putative calmodulin-like protein 6 CML6 Os11g0586200 LOC_Os11g37550 OsJ_033072 Oryza sativa subsp. japonica (Rice) TR35234_c13_g2_i1 Q5ZM44 CHP1_CHICK 2.00E-76 GO:0000139; GO:0005509; GO:0048306; GO:0071468; GO:0031122; GO:0005783; GO:0005793; GO:0019900; GO:0022406; GO:0061025; GO:0008017; GO:0001578; GO:0015630; GO:0032088; GO:0070885; GO:0010923; GO:0031953; GO:0042308; GO:0006469; GO:0031397; GO:0005634; GO:0005886; GO:0060050; GO:0090314; GO:0032417; GO:0006611; GO:0004860; GO:0050821; GO:0051453; GO:0030133; GO:0005215 Golgi membrane; calcium ion binding; calcium-dependent protein binding; cellular response to acidity; cytoplasmic microtubule organization; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; kinase binding; membrane docking; membrane fusion; microtubule binding; microtubule bundle formation; microtubule cytoskeleton; negative regulation of NF-kappaB transcription factor activity; negative regulation of calcineurin-NFAT signaling cascade; negative regulation of phosphatase activity; negative regulation of protein autophosphorylation; negative regulation of protein import into nucleus; negative regulation of protein kinase activity; negative regulation of protein ubiquitination; nucleus; plasma membrane; positive regulation of protein glycosylation; positive regulation of protein targeting to membrane; positive regulation of sodium:hydrogen antiporter activity; protein export from nucleus; protein kinase inhibitor activity; protein stabilization; regulation of intracellular pH; transport vesicle; transporter activity IPR011992; IPR018247; IPR002048; Calcineurin B homologous protein 1 (Calcineurin B-like protein) (Calcium-binding protein CHP) (Calcium-binding protein p22) (EF-hand calcium-binding domain-containing protein p22) CHP1 CHP RCJMB04_3d7 Gallus gallus (Chicken) TR35234_c15_g1_i1 Q00174 LAMA_DROME 1.00E-08 GO:0030424; GO:0007411; GO:0005605; GO:0048854; GO:0007155; GO:0030054; GO:0035001; GO:0016321; GO:0007507; GO:0007476; GO:0002121; GO:0005606; GO:0031987; GO:0035011; GO:0007498; GO:0045886; GO:0036062; GO:0030155; GO:0030334; GO:0045995; GO:0001964; GO:0008021 "axon; axon guidance; basal lamina; brain morphogenesis; cell adhesion; cell junction; dorsal trunk growth, open tracheal system; female meiosis chromosome segregation; heart development; imaginal disc-derived wing morphogenesis; inter-male aggressive behavior; laminin-1 complex; locomotion involved in locomotory behavior; melanotic encapsulation of foreign target; mesoderm development; negative regulation of synaptic growth at neuromuscular junction; presynaptic periactive zone; regulation of cell adhesion; regulation of cell migration; regulation of embryonic development; startle response; synaptic vesicle" IPR008985; IPR013320; IPR013032; IPR002049; IPR018031; IPR000034; IPR001791; IPR009254; IPR010307; IPR008211; Laminin subunit alpha (Laminin A chain) LanA lamA CG10236 Drosophila melanogaster (Fruit fly) TR35234_c15_g1_i2 Q16363 LAMA4_HUMAN 1.00E-08 GO:0005605; GO:0001568; GO:0050873; GO:0007155; GO:0030198; GO:0005201; GO:0070062; GO:0005606; GO:0030155; GO:0030334; GO:0045995 basal lamina; blood vessel development; brown fat cell differentiation; cell adhesion; extracellular matrix organization; extracellular matrix structural constituent; extracellular vesicular exosome; laminin-1 complex; regulation of cell adhesion; regulation of cell migration; regulation of embryonic development IPR008985; IPR013320; IPR002049; IPR001791; IPR009254; IPR010307; Laminin subunit alpha-4 (Laminin-14 subunit alpha) (Laminin-8 subunit alpha) (Laminin-9 subunit alpha) LAMA4 Homo sapiens (Human) TR35238_c0_g1_i1 Q9P2C4 TM181_HUMAN 2.00E-12 GO:0016021; GO:0009405; GO:0015643 integral to membrane; pathogenesis; toxic substance binding Transmembrane protein 181 TMEM181 GPR178 KIAA1423 Homo sapiens (Human) TR35238_c1_g2_i4 Q9P2C4 TM181_HUMAN 2.00E-36 GO:0016021; GO:0009405; GO:0015643 integral to membrane; pathogenesis; toxic substance binding Transmembrane protein 181 TMEM181 GPR178 KIAA1423 Homo sapiens (Human) TR35238_c2_g2_i11 Q9BXJ5 C1QT2_HUMAN 1.00E-07 GO:0000187; GO:0005581; GO:0005615; GO:0046321; GO:0046326; GO:0045725; GO:0070208; GO:0051260 activation of MAPK activity; collagen; extracellular space; positive regulation of fatty acid oxidation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; protein heterotrimerization; protein homooligomerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 2 C1QTNF2 CTRP2 UNQ6349/PRO21054 Homo sapiens (Human) TR35238_c2_g2_i13 Q9P2C4 TM181_HUMAN 2.00E-13 GO:0016021; GO:0009405; GO:0015643 integral to membrane; pathogenesis; toxic substance binding Transmembrane protein 181 TMEM181 GPR178 KIAA1423 Homo sapiens (Human) TR35238_c2_g2_i7 Q8R066 C1QT4_MOUSE 1.00E-06 GO:0005615 extracellular space IPR001073; IPR008983; Complement C1q tumor necrosis factor-related protein 4 C1qtnf4 Mus musculus (Mouse) TR35238_c2_g3_i1 P83425 HIP_MYTED 3.00E-06 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR35239_c0_g1_i1 Q26481 RL5_STYCL 3.00E-147 GO:0008097; GO:0005840; GO:0003735; GO:0006412 5S rRNA binding; ribosome; structural constituent of ribosome; translation IPR005485; IPR025607; IPR005484; 60S ribosomal protein L5 RPL5 Styela clava (Sea squirt) TR35241_c0_g2_i1 Q2T9W3 CCD63_BOVIN 6.00E-56 Coiled-coil domain-containing protein 63 CCDC63 Bos taurus (Bovine) TR35242_c1_g1_i1 Q32KI9 ARSI_MOUSE 2.00E-101 GO:0005783; GO:0005576; GO:0046872; GO:0008484 endoplasmic reticulum; extracellular region; metal ion binding; sulfuric ester hydrolase activity IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase I (ASI) (EC 3.1.6.-) Arsi Mus musculus (Mouse) TR35242_c1_g1_i2 P15848 ARSB_HUMAN 3.00E-78 GO:0005794; GO:0003943; GO:0004065; GO:0006914; GO:0005975; GO:0007417; GO:0030207; GO:0005788; GO:0006687; GO:0043202; GO:0007041; GO:0007040; GO:0046872; GO:0005739; GO:0043687; GO:0043627; GO:0051597; GO:0007584; GO:0009268; GO:0005791 Golgi apparatus; N-acetylgalactosamine-4-sulfatase activity; arylsulfatase activity; autophagy; carbohydrate metabolic process; central nervous system development; chondroitin sulfate catabolic process; endoplasmic reticulum lumen; glycosphingolipid metabolic process; lysosomal lumen; lysosomal transport; lysosome organization; metal ion binding; mitochondrion; post-translational protein modification; response to estrogen stimulus; response to methylmercury; response to nutrient; response to pH; rough endoplasmic reticulum IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) ARSB Homo sapiens (Human) TR35243_c0_g1_i1 Q5RFE6 THNS2_PONAB 2.00E-177 GO:0016829 lyase activity IPR004450; IPR001926; IPR027457; Threonine synthase-like 2 (TSH2) (EC 4.2.3.-) THNSL2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35243_c0_g1_i2 P57289 THRC_BUCAI 7.00E-44 GO:0030170; GO:0009088; GO:0004795 pyridoxal phosphate binding; threonine biosynthetic process; threonine synthase activity IPR000634; IPR004450; IPR001926; Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5. Threonine synthase (TS) (EC 4.2.3.1) thrC BU192 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) TR35246_c0_g1_i1 O18756 GLCE_BOVIN 5.00E-50 GO:0005794; GO:0000139; GO:0050379; GO:0015012; GO:0030210; GO:0047464; GO:0016021 Golgi apparatus; Golgi membrane; UDP-glucuronate 5'-epimerase activity; heparan sulfate proteoglycan biosynthetic process; heparin biosynthetic process; heparosan-N-sulfate-glucuronate 5-epimerase activity; integral to membrane IPR010598; Glycan metabolism; heparan sulfate biosynthesis. Glycan metabolism; heparin biosynthesis. D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase) GLCE Bos taurus (Bovine) TR35249_c0_g1_i4 Q9NQT8 KI13B_HUMAN 6.00E-15 GO:0071889; GO:0005524; GO:0042110; GO:0030424; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0007018; GO:0006605; GO:0050770; GO:0007165 Q12959-2 14-3-3 protein binding; ATP binding; T cell activation; axon; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement; protein targeting; regulation of axonogenesis; signal transduction IPR000938; IPR000253; IPR022140; IPR022164; IPR027640; IPR019821; IPR001752; IPR027417; IPR008984; Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) KIF13B GAKIN KIAA0639 Homo sapiens (Human) TR35250_c2_g1_i1 Q8K1C7 MOT14_MOUSE 4.00E-25 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) Slc16a14 Mct14 Mus musculus (Mouse) TR35250_c3_g1_i2 Q8R0M8 MOT5_MOUSE 5.00E-27 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 5 (MCT 5) Slc16a4 Mct5 Mus musculus (Mouse) TR35250_c3_g1_i3 Q7RTY1 MOT9_HUMAN 4.00E-10 GO:0016021; GO:0005886; GO:0015293; GO:0046415 integral to membrane; plasma membrane; symporter activity; urate metabolic process IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 C10orf36 MCT9 Homo sapiens (Human) TR35250_c4_g3_i1 Q6GQP4 RAB31_RAT 3.00E-41 GO:0019003; GO:0005525; GO:0005794; GO:0043001; GO:0032869; GO:0005769; GO:0045335; GO:0030670; GO:0090382; GO:0031623; GO:0045055; GO:0007264; GO:0032588 GDP binding; GTP binding; Golgi apparatus; Golgi to plasma membrane protein transport; cellular response to insulin stimulus; early endosome; phagocytic vesicle; phagocytic vesicle membrane; phagosome maturation; receptor internalization; regulated secretory pathway; small GTPase mediated signal transduction; trans-Golgi network membrane IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-31 (GTP-binding protein Rab0) Rab31 Rattus norvegicus (Rat) TR35250_c4_g3_i2 Q9CQD1 RAB5A_MOUSE 3.00E-45 GO:0019003; GO:0005525; GO:0003924; GO:0015629; GO:0030154; GO:0005769; GO:0031901; GO:0030139; GO:0006897; GO:0042470; GO:0045121; GO:0007399; GO:0005886; GO:0045921; GO:0015031; GO:2000286; GO:0051489; GO:0001726; GO:0007264 GDP binding; GTP binding; GTPase activity; actin cytoskeleton; cell differentiation; early endosome; early endosome membrane; endocytic vesicle; endocytosis; melanosome; membrane raft; nervous system development; plasma membrane; positive regulation of exocytosis; protein transport; receptor internalization involved in canonical Wnt receptor signaling pathway; regulation of filopodium assembly; ruffle; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-5A Rab5a nnyRab5a Mus musculus (Mouse) TR35253_c0_g1_i1 Q8BPB0 MOB1B_MOUSE 7.00E-139 GO:0005737; GO:0019209; GO:0019900; GO:0046872; GO:0005634; GO:0046777 cytoplasm; kinase activator activity; kinase binding; metal ion binding; nucleus; protein autophosphorylation IPR005301; MOB kinase activator 1B (Mob1 homolog 1A) (Mps one binder kinase activator-like 1A) Mob1b Mobkl1a Mus musculus (Mouse) TR35255_c0_g1_i3 Q19673 TYR3_CAEEL 1.00E-11 GO:0046872; GO:0004497 metal ion binding; monooxygenase activity IPR003582; IPR002227; IPR008922; Putative tyrosinase-like protein tyr-3 tyr-3 F21C3.2 Caenorhabditis elegans TR35256_c0_g4_i1 P18841 ADA1B_MESAU 8.00E-14 GO:0071875; GO:0004937; GO:0016021; GO:0031965; GO:0005886; GO:0043410; GO:0046982; GO:0055117; GO:0019229 O35796 adrenergic receptor signaling pathway; alpha1-adrenergic receptor activity; integral to membrane; nuclear membrane; plasma membrane; positive regulation of MAPK cascade; protein heterodimerization activity; regulation of cardiac muscle contraction; regulation of vasoconstriction IPR002233; IPR001115; IPR000276; IPR017452; Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) ADRA1B Mesocricetus auratus (Golden hamster) TR35256_c0_g4_i2 P42288 DRD1_DIDVI 8.00E-08 GO:0004952; GO:0007212; GO:0005789; GO:0005887; GO:0010579; GO:0042311 dopamine neurotransmitter receptor activity; dopamine receptor signaling pathway; endoplasmic reticulum membrane; integral to plasma membrane; positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway; vasodilation IPR001413; IPR000497; IPR000929; IPR000276; IPR017452; D(1A) dopamine receptor (Dopamine D1 receptor) DRD1 Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) TR35256_c0_g4_i3 P97292 HRH2_MOUSE 1.00E-15 GO:0001696; GO:0004969; GO:0016021; GO:0005886; GO:0045907 gastric acid secretion; histamine receptor activity; integral to membrane; plasma membrane; positive regulation of vasoconstriction IPR000276; IPR017452; IPR000503; Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I) Hrh2 Mus musculus (Mouse) TR35257_c2_g1_i2 Q3T0E5 APMAP_BOVIN 1.00E-56 GO:0004064; GO:0009058; GO:0009986; GO:0016021; GO:0016844 arylesterase activity; biosynthetic process; cell surface; integral to membrane; strictosidine synthase activity IPR011042; IPR018119; Adipocyte plasma membrane-associated protein APMAP Bos taurus (Bovine) TR35257_c2_g2_i1 Q9D7N9 APMAP_MOUSE 1.00E-12 GO:0004064; GO:0009058; GO:0009986; GO:0016021; GO:0016844 arylesterase activity; biosynthetic process; cell surface; integral to membrane; strictosidine synthase activity IPR011042; IPR018119; Adipocyte plasma membrane-associated protein (Protein DD16) Apmap Mus musculus (Mouse) TR35258_c0_g1_i1 Q9DEB5 FZ10A_XENLA 0 GO:0004930; GO:0016055; GO:0042813; GO:0016021; GO:0007275; GO:0005886 G-protein coupled receptor activity; Wnt receptor signaling pathway; Wnt-activated receptor activity; integral to membrane; multicellular organismal development; plasma membrane IPR000539; IPR015526; IPR020067; IPR026549; IPR017981; Frizzled-10-A (Fz-10A) (Xfz10-A) fzd10-a fz10a Xenopus laevis (African clawed frog) TR35259_c2_g1_i1 Q5U4E6 GOGA4_RAT 2.00E-20 GO:0000139; GO:0000042 Golgi membrane; protein targeting to Golgi IPR000237; Golgin subfamily A member 4 Golga4 Rattus norvegicus (Rat) TR35260_c1_g3_i1 Q96BD5 PF21A_HUMAN 1.00E-44 GO:0003677; GO:0007596; GO:0003682; GO:0016568; GO:0000118; GO:0000122; GO:0006355; GO:0001967; GO:0006351; GO:0008270 "DNA binding; blood coagulation; chromatin binding; chromatin modification; histone deacetylase complex; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; suckling behavior; transcription, DNA-dependent; zinc ion binding" IPR017956; IPR019786; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80) PHF21A BHC80 KIAA1696 BM-006 Homo sapiens (Human) TR35260_c7_g1_i1 Q8QFV0 KCNT1_CHICK 7.00E-63 GO:0015269; GO:0005249; GO:0008076 calcium-activated potassium channel activity; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR013099; IPR003929; IPR016040; Potassium channel subfamily T member 1 (Sequence like a calcium-activated potassium channel subunit) KCNT1 SLACK Gallus gallus (Chicken) TR35263_c0_g1_i1 Q9CWR2 SMYD3_MOUSE 4.00E-45 GO:0005737; GO:0018024; GO:0046872; GO:0005634 cytoplasm; histone-lysine N-methyltransferase activity; metal ion binding; nucleus IPR025805; IPR001214; IPR002893; Histone-lysine N-methyltransferase SMYD3 (EC 2.1.1.43) (SET and MYND domain-containing protein 3) (Zinc finger MYND domain-containing protein 1) Smyd3 Zmynd1 Mus musculus (Mouse) TR35263_c0_g1_i3 Q54D67 Y2454_DICDI 3.00E-07 GO:0046872; GO:0008168 metal ion binding; methyltransferase activity IPR001214; IPR002893; SET and MYND domain-containing protein DDB_G0292454 (EC 2.1.1.-) DDB_G0292454 Dictyostelium discoideum (Slime mold) TR35264_c1_g3_i2 O43432 IF4G3_HUMAN 1.00E-15 GO:0000339; GO:0019221; GO:0005829; GO:0016281; GO:0019048; GO:0006446; GO:0008135; GO:0003743 "RNA cap binding; cytokine-mediated signaling pathway; cytosol; eukaryotic translation initiation factor 4F complex; modulation by virus of host morphology or physiology; regulation of translational initiation; translation factor activity, nucleic acid binding; translation initiation factor activity" IPR016024; IPR003891; IPR016021; IPR003890; IPR003307; Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) EIF4G3 Homo sapiens (Human) TR35264_c1_g3_i3 Q6NZJ6 IF4G1_MOUSE 3.00E-12 GO:0005737; GO:0006417; GO:0003743 Q8JZQ9; Q9QZD9; P60843; P63073 cytoplasm; regulation of translation; translation initiation factor activity IPR016024; IPR003891; IPR016021; IPR003890; IPR003307; Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) Eif4g1 Mus musculus (Mouse) TR35266_c2_g1_i1 P42577 FRIS_LYMST 1.00E-97 GO:0006879; GO:0005737; GO:0008199; GO:0004322; GO:0006826 cellular iron ion homeostasis; cytoplasm; ferric iron binding; ferroxidase activity; iron ion transport IPR001519; IPR009040; IPR009078; IPR012347; IPR014034; IPR008331; Soma ferritin (EC 1.16.3.1) Lymnaea stagnalis (Great pond snail) TR35266_c2_g1_i2 P42577 FRIS_LYMST 1.00E-97 GO:0006879; GO:0005737; GO:0008199; GO:0004322; GO:0006826 cellular iron ion homeostasis; cytoplasm; ferric iron binding; ferroxidase activity; iron ion transport IPR001519; IPR009040; IPR009078; IPR012347; IPR014034; IPR008331; Soma ferritin (EC 1.16.3.1) Lymnaea stagnalis (Great pond snail) TR35270_c2_g1_i1 Q66KD9 CO044_XENTR 0 IPR002035; von Willebrand factor A domain-containing protein 9 vwa9 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35271_c7_g1_i1 Q6PIJ6 FBX38_HUMAN 1.00E-52 GO:0005737; GO:0005634 cytoplasm; nucleus IPR001810; F-box only protein 38 (Modulator of KLF7 activity homolog) (MoKA) FBXO38 SP329 Homo sapiens (Human) TR35271_c7_g1_i2 Q6PIJ6 FBX38_HUMAN 6.00E-53 GO:0005737; GO:0005634 cytoplasm; nucleus IPR001810; F-box only protein 38 (Modulator of KLF7 activity homolog) (MoKA) FBXO38 SP329 Homo sapiens (Human) TR35273_c1_g1_i1 Q28EM8 LTMD1_XENTR 3.00E-28 GO:0016021; GO:0005741 integral to membrane; mitochondrial outer membrane IPR011685; LETM1 domain-containing protein 1 letmd1 TGas100d16.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35273_c1_g1_i2 Q924L1 LTMD1_MOUSE 3.00E-29 GO:0016021; GO:0005741; GO:0005739 integral to membrane; mitochondrial outer membrane; mitochondrion IPR011685; LETM1 domain-containing protein 1 (Cervical cancer receptor) (MCC-32) Letmd1 Mccr Mus musculus (Mouse) TR35274_c2_g1_i1 O60478 G137B_HUMAN 2.00E-59 GO:0005887; GO:0005765 integral to plasma membrane; lysosomal membrane Integral membrane protein GPR137B (Transmembrane 7 superfamily member 1 protein) GPR137B TM7SF1 Homo sapiens (Human) TR35274_c5_g1_i1 Q96N19 G137A_HUMAN 3.00E-24 GO:0016021 integral to membrane IPR027209; Integral membrane protein GPR137 (Transmembrane 7 superfamily member 1-like 1 protein) GPR137 C11orf4 GPR137A TM7SF1L1 Homo sapiens (Human) TR35276_c0_g3_i1 Q0VD26 MORN4_BOVIN 1.00E-42 IPR003409; MORN repeat-containing protein 4 MORN4 Bos taurus (Bovine) TR35278_c3_g2_i1 Q9NP81 SYSM_HUMAN 6.00E-76 GO:0005524; GO:0005759; GO:0097056; GO:0004828; GO:0006434 ATP binding; mitochondrial matrix; selenocysteinyl-tRNA(Sec) biosynthetic process; serine-tRNA ligase activity; seryl-tRNA aminoacylation IPR002314; IPR006195; IPR002317; IPR015866; IPR010978; Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1. "Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)" SARS2 SARSM Homo sapiens (Human) TR35278_c4_g1_i1 Q9DB72 BTBDH_MOUSE 3.00E-06 GO:0005576 extracellular region IPR011705; IPR000210; IPR011333; IPR013069; BTB/POZ domain-containing protein 17 (Galectin-3-binding protein-like) Btbd17 Mus musculus (Mouse) TR35279_c4_g1_i1 P59222 SREC2_MOUSE 2.00E-06 GO:0007157; GO:0016021; GO:0005044 heterophilic cell-cell adhesion; integral to membrane; scavenger receptor activity IPR000742; IPR013032; IPR009030; Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) TR35279_c5_g1_i1 P28827 PTPRM_HUMAN 5.00E-100 GO:0045296; GO:0005913; GO:0007156; GO:0005887; GO:0030027; GO:0016525; GO:0010596; GO:0001937; GO:0048471; GO:0045909; GO:0042493; GO:0010842; GO:0031290; GO:0005001 Itself; P09803 cadherin binding; cell-cell adherens junction; homophilic cell adhesion; integral to plasma membrane; lamellipodium; negative regulation of angiogenesis; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; perinuclear region of cytoplasm; positive regulation of vasodilation; response to drug; retina layer formation; retinal ganglion cell axon guidance; transmembrane receptor protein tyrosine phosphatase activity IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR013151; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) TR35279_c5_g1_i3 P29461 PTP2_YEAST 4.00E-07 GO:0005737; GO:0000200; GO:0000173; GO:0005634; GO:0004725; GO:0032880; GO:0043937 cytoplasm; inactivation of MAPK activity involved in cell wall biogenesis; inactivation of MAPK activity involved in osmosensory signaling pathway; nucleus; protein tyrosine phosphatase activity; regulation of protein localization; regulation of sporulation IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2) (PTPase 2) PTP2 YOR208W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR35280_c1_g2_i1 Q6UXX5 ITIH6_HUMAN 2.00E-51 GO:0005576; GO:0030212; GO:0004867 extracellular region; hyaluronan metabolic process; serine-type endopeptidase inhibitor activity IPR010600; IPR013694; IPR002035; Inter-alpha-trypsin inhibitor heavy chain H6 (Inter-alpha-trypsin inhibitor heavy chain H5-like protein) (Inter-alpha inhibitor H5-like protein) ITIH6 ITIH5L UNQ6369/PRO21074 Homo sapiens (Human) TR35282_c2_g1_i1 Q6PBT6 GFRP_DANRE 2.00E-32 GO:0005829; GO:0009890; GO:0031965 cytosol; negative regulation of biosynthetic process; nuclear membrane IPR009112; GTP cyclohydrolase 1 feedback regulatory protein (GFRP) (GTP cyclohydrolase I feedback regulatory protein) gchfr Danio rerio (Zebrafish) (Brachydanio rerio) TR35283_c5_g1_i1 P31228 OXDD_BOVIN 5.00E-72 GO:0003884; GO:0008445; GO:0005777 D-amino-acid oxidase activity; D-aspartate oxidase activity; peroxisome IPR023209; IPR006181; IPR006076; IPR016040; D-aspartate oxidase (DASOX) (DDO) (EC 1.4.3.1) DDO Bos taurus (Bovine) TR35283_c5_g1_i2 P31228 OXDD_BOVIN 1.00E-71 GO:0003884; GO:0008445; GO:0005777 D-amino-acid oxidase activity; D-aspartate oxidase activity; peroxisome IPR023209; IPR006181; IPR006076; IPR016040; D-aspartate oxidase (DASOX) (DDO) (EC 1.4.3.1) DDO Bos taurus (Bovine) TR35284_c1_g1_i3 Q9WTV8 V1AR_MICMA 9.00E-10 GO:0016021; GO:0005886; GO:0005000 integral to membrane; plasma membrane; vasopressin receptor activity IPR015076; IPR000276; IPR017452; IPR001817; IPR001224; Vasopressin V1a receptor (V1aR) (AVPR V1a) (Antidiuretic hormone receptor 1a) (Vascular/hepatic-type arginine vasopressin receptor) Avpr1a Microtus montanus (Montane vole) TR35286_c0_g1_i1 O75521 ECI2_HUMAN 4.00E-134 GO:0004165; GO:0009062; GO:0000062; GO:0005739; GO:0005782 dodecenoyl-CoA delta-isomerase activity; fatty acid catabolic process; fatty-acyl-CoA binding; mitochondrion; peroxisomal matrix IPR022408; IPR000582; IPR001753; IPR014352; "Enoyl-CoA delta isomerase 2, mitochondrial (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1)" ECI2 DRS1 HCA88 PECI Homo sapiens (Human) TR35286_c0_g1_i2 Q9WUR2 ECI2_MOUSE 5.00E-143 GO:0004165; GO:0006635; GO:0009062; GO:0000062; GO:0005739; GO:0005782; GO:0005777 dodecenoyl-CoA delta-isomerase activity; fatty acid beta-oxidation; fatty acid catabolic process; fatty-acyl-CoA binding; mitochondrion; peroxisomal matrix; peroxisome IPR022408; IPR000582; IPR001753; IPR014352; "Enoyl-CoA delta isomerase 2, mitochondrial (EC 5.3.3.8) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI)" Eci2 Peci Mus musculus (Mouse) TR35287_c0_g1_i2 Q8IWV8 UBR2_HUMAN 1.00E-165 GO:0071233; GO:0000785; GO:0006342; GO:0033522; GO:0070728; GO:0007141; GO:0032007; GO:0005634; GO:0005886; GO:0007283; GO:0000151; GO:0006511; GO:0004842; GO:0008270 P12504 cellular response to leucine; chromatin; chromatin silencing; histone H2A ubiquitination; leucine binding; male meiosis I; negative regulation of TOR signaling cascade; nucleus; plasma membrane; spermatogenesis; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR003769; IPR014719; IPR003126; IPR013993; IPR001841; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UBR2 (EC 6.3.2.-) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II) UBR2 C6orf133 KIAA0349 Homo sapiens (Human) TR35298_c1_g1_i1 Q9QYM0 MRP5_RAT 7.00E-98 GO:0005524; GO:0006200; GO:0042626; GO:0016021; GO:0048471; GO:0032868; GO:0032496 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; perinuclear region of cytoplasm; response to insulin stimulus; response to lipopolysaccharide" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) Abcc5 Abcc5a Mrp5 Rattus norvegicus (Rat) TR35298_c2_g1_i1 Q54V86 ABCCD_DICDI 8.00E-17 GO:0005524; GO:0042626; GO:0031154; GO:0016021; GO:0031288 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; culmination involved in sorocarp development; integral to membrane; sorocarp morphogenesis" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; ABC transporter C family member 13 (ABC transporter ABCC.13) abcC13 DDB_G0280539 Dictyostelium discoideum (Slime mold) TR35298_c2_g2_i2 P0CE68 NFT1_YEAST 4.00E-49 GO:0005524; GO:0042626; GO:0000329; GO:0016021 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; fungal-type vacuole membrane; integral to membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; ABC transporter NFT1 (New full-length MRP-type transporter 1) NFT1 YKR103W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR35298_c2_g2_i3 P36497 PEDD_PEDAC 3.00E-23 GO:0005524; GO:0006200; GO:0042626; GO:0022885; GO:0008234; GO:0016021; GO:0005886; GO:0006508 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; bacteriocin transmembrane transporter activity; cysteine-type peptidase activity; integral to membrane; plasma membrane; proteolysis" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; IPR005897; IPR005074; Pediocin PA-1 transport/processing ATP-binding protein PedD (EC 3.4.22.-) (Pediocin AcH transport ATP-binding protein PapD) pedD papD Pediococcus acidilactici TR35298_c3_g1_i1 Q10185 ABC2_SCHPO 5.00E-108 GO:0005524; GO:0005794; GO:0071276; GO:0000329; GO:0071997; GO:0071996; GO:0016021; GO:0071995; GO:0071992; GO:0009636 ATP binding; Golgi apparatus; cellular response to cadmium ion; fungal-type vacuole membrane; glutathione S-conjugate-transporting ATPase activity; glutathione transmembrane import into vacuole; integral to membrane; phytochelatin import into vacuole; phytochelatin transmembrane transporter activity; response to toxic substance IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; ATP-binding cassette transporter abc2 (ABC transporter abc2) (EC 3.6.3.-) (ATP-energized glutathione S-conjugate pump abc2) (Glutathione S-conjugate-transporting ATPase abc2) abc2 SPAC3F10.11c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR35298_c3_g1_i3 Q5WKL3 METN1_BACSK 3.00E-10 GO:0005524; GO:0006200; GO:0016887; GO:0043865; GO:0005886 ATP binding; ATP catabolic process; ATPase activity; methionine transmembrane transporter activity; plasma membrane IPR003593; IPR026253; IPR003439; IPR017871; IPR017908; IPR018449; IPR027417; Methionine import ATP-binding protein MetN 1 (EC 3.6.3.-) metN1 ABC0552 Bacillus clausii (strain KSM-K16) TR35298_c3_g1_i4 O15440 MRP5_HUMAN 3.00E-151 GO:0005524; GO:0006200; GO:0042626; GO:0005975; GO:0030213; GO:0005887; GO:0008514 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; carbohydrate metabolic process; hyaluronan biosynthetic process; integral to plasma membrane; organic anion transmembrane transporter activity" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) (pABC11) ABCC5 MRP5 Homo sapiens (Human) TR35301_c3_g2_i1 Q5ZLK1 DCA13_CHICK 0 GO:0080008; GO:0005730; GO:0016567; GO:0006364; GO:0030529 Cul4-RING ubiquitin ligase complex; nucleolus; protein ubiquitination; rRNA processing; ribonucleoprotein complex IPR007287; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 13 (WD repeat and SOF domain-containing protein 1) DCAF13 WDSOF1 RCJMB04_5m12 Gallus gallus (Chicken) TR35301_c3_g2_i2 Q7ZUV2 KTNB1_DANRE 4.00E-08 GO:0051301; GO:0008352; GO:0005874; GO:0051013; GO:0007067; GO:0000922 cell division; katanin complex; microtubule; microtubule severing; mitosis; spindle pole IPR020472; IPR026962; IPR028021; IPR015943; IPR001680; IPR019775; IPR017986; Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) katnb1 zgc:56071 Danio rerio (Zebrafish) (Brachydanio rerio) TR35301_c3_g2_i3 O75529 TAF5L_HUMAN 2.00E-07 GO:0030914; GO:0043966; GO:0003700; GO:0003713; GO:0033276; GO:0006366 STAGA complex; histone H3 acetylation; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription factor TFTC complex; transcription from RNA polymerase II promoter IPR020472; IPR007582; IPR015943; IPR001680; IPR019775; IPR017986; TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65-beta) TAF5L PAF65B Homo sapiens (Human) TR35301_c3_g2_i4 Q5ZLK1 DCA13_CHICK 0 GO:0080008; GO:0005730; GO:0016567; GO:0006364; GO:0030529 Cul4-RING ubiquitin ligase complex; nucleolus; protein ubiquitination; rRNA processing; ribonucleoprotein complex IPR007287; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 13 (WD repeat and SOF domain-containing protein 1) DCAF13 WDSOF1 RCJMB04_5m12 Gallus gallus (Chicken) TR35303_c2_g1_i1 Q2TAA8 TXIP1_HUMAN 3.00E-76 GO:0030154; GO:0007275; GO:0048471; GO:0007283 cell differentiation; multicellular organismal development; perinuclear region of cytoplasm; spermatogenesis Translin-associated factor X-interacting protein 1 (Trax-interacting protein 1) TSNAXIP1 TXI1 Homo sapiens (Human) TR35305_c0_g1_i2 P28824 NRP1_XENLA 4.00E-19 GO:0001525; GO:0007411; GO:0007155; GO:0035767; GO:0008201; GO:0016021; GO:0046872; GO:0009887; GO:0017154; GO:0048010; GO:0005021 angiogenesis; axon guidance; cell adhesion; endothelial cell chemotaxis; heparin binding; integral to membrane; metal ion binding; organ morphogenesis; semaphorin receptor activity; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor-activated receptor activity IPR000421; IPR008985; IPR000859; IPR008979; IPR000998; IPR014648; IPR022579; IPR027146; Neuropilin-1 (A5 antigen) (A5 protein) nrp1 Xenopus laevis (African clawed frog) TR35305_c1_g1_i2 Q9GMT4 MDGA2_MACFA 2.00E-25 GO:0031225; GO:0005886 anchored to membrane; plasma membrane IPR008985; IPR003961; IPR007110; IPR013783; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 2 (MAM domain-containing protein 1) (Fragment) MDGA2 MAMDC1 QccE-16296 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR35305_c1_g1_i4 Q91641 THIB_XENLA 9.00E-27 GO:0005615; GO:0016020; GO:0007275 extracellular space; membrane; multicellular organismal development IPR008985; IPR000998; Thyroid hormone-induced protein B Xenopus laevis (African clawed frog) TR35305_c1_g1_i7 Q91641 THIB_XENLA 8.00E-27 GO:0005615; GO:0016020; GO:0007275 extracellular space; membrane; multicellular organismal development IPR008985; IPR000998; Thyroid hormone-induced protein B Xenopus laevis (African clawed frog) TR35306_c0_g1_i1 Q9NPB0 SMDC1_HUMAN 2.00E-11 GO:0030659; GO:0016021 cytoplasmic vesicle membrane; integral to membrane IPR019387; SAYSvFN domain-containing protein 1 SAYSD1 C6orf64 Homo sapiens (Human) TR35306_c4_g2_i5 Q7YR89 CYHR1_BOVIN 7.00E-116 GO:0046872; GO:0005635; GO:0048471 metal ion binding; nuclear envelope; perinuclear region of cytoplasm IPR008974; Cysteine and histidine-rich protein 1 CYHR1 Bos taurus (Bovine) TR35306_c4_g2_i6 Q5BK76 CYHR1_RAT 2.00E-67 GO:0005635; GO:0048471; GO:0008270 nuclear envelope; perinuclear region of cytoplasm; zinc ion binding IPR008974; IPR013083; IPR001293; Cysteine and histidine-rich protein 1 Cyhr1 Rattus norvegicus (Rat) TR35307_c1_g1_i1 Q6DED0 TR1L1_XENLA 4.00E-117 GO:0005789; GO:0016021; GO:0015031 endoplasmic reticulum membrane; integral to membrane; protein transport IPR006634; IPR013599; IPR016447; Translocating chain-associated membrane protein 1-like 1 tram1l1 Xenopus laevis (African clawed frog) TR35313_c0_g1_i1 Q6NU08 MTRAB_XENLA 6.00E-105 GO:0016791 phosphatase activity IPR010569; IPR022587; IPR017906; IPR011993; Myotubularin-related protein 10-B mtmr10-b Xenopus laevis (African clawed frog) TR35313_c0_g1_i3 Q80TA6 MTMRC_MOUSE 5.00E-95 GO:0005737; GO:0016791 cytoplasm; phosphatase activity IPR010569; IPR022587; IPR017906; IPR011993; Myotubularin-related protein 12 Mtmr12 Kiaa1682 Mus musculus (Mouse) TR35315_c0_g2_i1 Q70UN9 ADH1_CERCO 2.00E-19 GO:0004022 alcohol dehydrogenase (NAD) activity IPR002426; IPR002424; IPR002198; IPR016040; IPR020904; Alcohol dehydrogenase 1 (EC 1.1.1.1) ADH1 Ceratitis cosyra (Mango fruit fly) (Trypeta cosyra) TR35315_c0_g2_i2 P70684 PGDH_CAVPO 7.00E-43 GO:0016404; GO:0070403; GO:0005737; GO:0097070; GO:0007565; GO:0045786; GO:0030728; GO:0007567; GO:0004957; GO:0006693; GO:0070493; GO:0007179 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; NAD+ binding; cytoplasm; ductus arteriosus closure; female pregnancy; negative regulation of cell cycle; ovulation; parturition; prostaglandin E receptor activity; prostaglandin metabolic process; thrombin receptor signaling pathway; transforming growth factor beta receptor signaling pathway IPR002198; IPR002347; IPR016040; IPR020904; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) HPGD PGDH1 Cavia porcellus (Guinea pig) TR35316_c1_g1_i1 P80585 TBCA_CHICK 2.00E-13 GO:0005737; GO:0005874; GO:0007021 cytoplasm; microtubule; tubulin complex assembly IPR004226; Tubulin-specific chaperone A (TCP1-chaperonin cofactor A) (Tubulin-folding cofactor A) (CFA) TBCA Gallus gallus (Chicken) TR35316_c1_g1_i2 P80585 TBCA_CHICK 2.00E-25 GO:0005737; GO:0005874; GO:0007021 cytoplasm; microtubule; tubulin complex assembly IPR004226; Tubulin-specific chaperone A (TCP1-chaperonin cofactor A) (Tubulin-folding cofactor A) (CFA) TBCA Gallus gallus (Chicken) TR35317_c0_g1_i5 Q9BWL3 CA043_HUMAN 3.00E-29 GO:0050662; GO:0016021; GO:0016616 "coenzyme binding; integral to membrane; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" IPR013328; IPR010876; Uncharacterized protein C1orf43 (Hepatitis C virus NS5A-transactivated protein 4) (HCV NS5A-transactivated protein 4) (Protein NICE-3) (S863-3) C1orf43 NICE3 NS5ATP4 HSPC012 Homo sapiens (Human) TR35318_c1_g1_i3 Q13263 TIF1B_HUMAN 3.00E-09 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR35318_c1_g1_i4 Q6PFY8 TRI45_MOUSE 4.00E-08 GO:0060348; GO:0005737; GO:0005634; GO:0008270 bone development; cytoplasm; nucleus; zinc ion binding IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) TR35318_c1_g1_i5 Q1PSW8 LIN41_MOUSE 6.00E-15 GO:0000082; GO:0000932; GO:0008543; GO:0035198; GO:0010586; GO:0035278; GO:0001843; GO:2000637; GO:0051865; GO:2000177; GO:0072089; GO:0004842; GO:0008270 G1/S transition of mitotic cell cycle; cytoplasmic mRNA processing body; fibroblast growth factor receptor signaling pathway; miRNA binding; miRNA metabolic process; negative regulation of translation involved in gene silencing by miRNA; neural tube closure; positive regulation of gene silencing by miRNA; protein autoubiquitination; regulation of neural precursor cell proliferation; stem cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (mLin41) (Tripartite motif-containing protein 71) Trim71 Gm1127 Lin41 Mus musculus (Mouse) TR35318_c1_g1_i8 Q1PSW8 LIN41_MOUSE 4.00E-14 GO:0000082; GO:0000932; GO:0008543; GO:0035198; GO:0010586; GO:0035278; GO:0001843; GO:2000637; GO:0051865; GO:2000177; GO:0072089; GO:0004842; GO:0008270 G1/S transition of mitotic cell cycle; cytoplasmic mRNA processing body; fibroblast growth factor receptor signaling pathway; miRNA binding; miRNA metabolic process; negative regulation of translation involved in gene silencing by miRNA; neural tube closure; positive regulation of gene silencing by miRNA; protein autoubiquitination; regulation of neural precursor cell proliferation; stem cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (mLin41) (Tripartite motif-containing protein 71) Trim71 Gm1127 Lin41 Mus musculus (Mouse) TR35319_c0_g2_i1 Q6P4Z6 LCMT1_RAT 3.00E-18 GO:0008168 methyltransferase activity IPR007213; IPR016651; Leucine carboxyl methyltransferase 1 (EC 2.1.1.233) ([Phosphatase 2A protein]-leucine-carboxy methyltransferase 1) Lcmt1 Rattus norvegicus (Rat) TR35319_c3_g1_i1 Q5AQJ2 LCMT1_EMENI 2.00E-12 GO:0008168 methyltransferase activity IPR007213; IPR016651; Leucine carboxyl methyltransferase 1 (EC 2.1.1.233) (Protein phosphatase methyltransferase 1) ([Phosphatase 2A protein]-leucine-carboxy methyltransferase 1) ppm1 AN9438 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR35319_c6_g1_i1 O60294 LCMT2_HUMAN 1.00E-19 GO:0008168; GO:0008033 methyltransferase activity; tRNA processing IPR015915; IPR007213; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. Leucine carboxyl methyltransferase 2 (EC 2.1.1.-) (p21WAF1/CIP1 promoter-interacting protein) (tRNA wybutosine-synthesizing protein 4 homolog) (tRNA yW-synthesizing protein 4 homolog) LCMT2 KIAA0547 TYW4 Homo sapiens (Human) TR35319_c6_g1_i2 P87061 TEA1_SCHPO 7.00E-08 GO:0031500; GO:0051285; GO:0032153; GO:0034613; GO:0071963; GO:0035838; GO:0005874; GO:0007017; GO:0035839; GO:2000771; GO:0032465; GO:0010570 O14248; O60132; P79065 Tea1 cell-end complex; cell cortex of cell tip; cell division site; cellular protein localization; establishment or maintenance of cell polarity regulating cell shape; growing cell tip; microtubule; microtubule-based process; non-growing cell tip; positive regulation of establishment or maintenance of cell polarity regulating cell shape; regulation of cytokinesis; regulation of filamentous growth IPR015915; IPR006652; IPR011498; Tip elongation aberrant protein 1 (Altered polarity protein 8) (Cell polarity protein tea1) tea1 alp8 SPCC1223.06 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR35319_c6_g2_i1 O60294 LCMT2_HUMAN 2.00E-09 GO:0008168; GO:0008033 methyltransferase activity; tRNA processing IPR015915; IPR007213; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. Leucine carboxyl methyltransferase 2 (EC 2.1.1.-) (p21WAF1/CIP1 promoter-interacting protein) (tRNA wybutosine-synthesizing protein 4 homolog) (tRNA yW-synthesizing protein 4 homolog) LCMT2 KIAA0547 TYW4 Homo sapiens (Human) TR35320_c0_g1_i1 Q09653 C13AA_CAEEL 4.00E-88 GO:0019373; GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016491; GO:0016705 "epoxygenase P450 pathway; heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Putative cytochrome P450 CYP13A10 (EC 1.14.-.-) cyp-13A10 cyp13a10 ZK1320.4 Caenorhabditis elegans TR35321_c0_g1_i1 O14508 SOCS2_HUMAN 1.00E-26 GO:0008269; GO:0060397; GO:0005070; GO:0007568; GO:0005829; GO:0005131; GO:0043066; GO:0009968; GO:0005148; GO:0016567; GO:0001558; GO:0032355 P19235; Q15369 JAK pathway signal transduction adaptor activity; JAK-STAT cascade involved in growth hormone signaling pathway; SH3/SH2 adaptor activity; aging; cytosol; growth hormone receptor binding; negative regulation of apoptotic process; negative regulation of signal transduction; prolactin receptor binding; protein ubiquitination; regulation of cell growth; response to estradiol stimulus IPR000980; IPR001496; Protein modification; protein ubiquitination. Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2) SOCS2 CIS2 SSI2 STATI2 Homo sapiens (Human) TR35324_c6_g1_i1 Q08CG8 RNF44_DANRE 3.00E-21 GO:0008270 zinc ion binding IPR001841; IPR013083; RING finger protein 44 rnf44 zgc:153103 Danio rerio (Zebrafish) (Brachydanio rerio) TR35325_c2_g1_i1 Q9JIY2 HAKAI_MOUSE 2.00E-36 GO:0016337; GO:0007162; GO:0030335; GO:0045807; GO:0004842; GO:0008270 Itself; P12830; Q14247; Q60598; Q99704 cell-cell adhesion; negative regulation of cell adhesion; positive regulation of cell migration; positive regulation of endocytosis; ubiquitin-protein ligase activity; zinc ion binding IPR015880; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase Hakai (EC 6.3.2.-) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (E-cadherin binding protein E7) (c-Cbl-like protein 1) Cbll1 Hakai Mus musculus (Mouse) TR35326_c0_g1_i1 Q8RAR7 Y1135_THETN 7.00E-25 GO:0003677; GO:0005737; GO:0006355; GO:0006351 "DNA binding; cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR017856; IPR002876; IPR026563; IPR026564; Probable transcriptional regulatory protein TTE1135 TTE1135 Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis) TR35326_c0_g1_i2 Q92M88 Y2753_RHIME 2.00E-26 GO:0003677; GO:0005737; GO:0006355; GO:0006351 "DNA binding; cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR017856; IPR002876; IPR026563; IPR026564; Probable transcriptional regulatory protein R02753 R02753 SMc03969 Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) TR35327_c0_g1_i3 P02701 AVID_CHICK 3.00E-10 GO:0005576 extracellular region IPR005469; IPR017889; IPR005468; Avidin AVD Gallus gallus (Chicken) TR35327_c0_g2_i1 Q53533 SAV2_STRVL 6.00E-18 GO:0005576 extracellular region IPR005469; IPR017889; IPR005468; Streptavidin-V2 (SA V2) Streptomyces violaceus (Streptomyces venezuelae) TR35328_c0_g1_i1 Q7TN79 AKA7G_MOUSE 1.00E-08 GO:0003824; GO:0005737; GO:0008152; GO:0000166; GO:0005634; GO:0034237; GO:0019901; GO:0008104; GO:0007178 catalytic activity; cytoplasm; metabolic process; nucleotide binding; nucleus; protein kinase A regulatory subunit binding; protein kinase binding; protein localization; transmembrane receptor protein serine/threonine kinase signaling pathway IPR019510; IPR019511; IPR009097; A-kinase anchor protein 7 isoform gamma (AKAP-7 isoform gamma) (A-kinase anchor protein 18) (AKAP-18) (Protein kinase A-anchoring protein 7 isoform gamma) (PRKA7 isoform gamma) Akap7 Akap18 Mus musculus (Mouse) TR35328_c0_g1_i2 Q9D8Z1 ASCC1_MOUSE 3.00E-95 GO:0003723; GO:0003824; GO:0005737; GO:0006355; GO:0005667; GO:0006351 "RNA binding; catalytic activity; cytoplasm; regulation of transcription, DNA-dependent; transcription factor complex; transcription, DNA-dependent" IPR009210; IPR004087; IPR004088; IPR019510; IPR009097; Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50) Ascc1 Mus musculus (Mouse) TR35328_c0_g1_i3 Q9D8Z1 ASCC1_MOUSE 8.00E-82 GO:0003723; GO:0003824; GO:0005737; GO:0006355; GO:0005667; GO:0006351 "RNA binding; catalytic activity; cytoplasm; regulation of transcription, DNA-dependent; transcription factor complex; transcription, DNA-dependent" IPR009210; IPR004087; IPR004088; IPR019510; IPR009097; Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50) Ascc1 Mus musculus (Mouse) TR35331_c0_g1_i1 Q6JQN1 ACD10_HUMAN 0 GO:0003995; GO:0050660; GO:0016787; GO:0005739; GO:0016772 "acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; hydrolase activity; mitochondrion; transferase activity, transferring phosphorus-containing groups" IPR006091; IPR009075; IPR013786; IPR009100; IPR002575; IPR023214; IPR006439; IPR011945; IPR011009; IPR023198; Acyl-CoA dehydrogenase family member 10 (ACAD-10) (EC 1.3.99.-) ACAD10 Homo sapiens (Human) TR35331_c0_g1_i3 Q6JQN1 ACD10_HUMAN 0 GO:0003995; GO:0050660; GO:0016787; GO:0005739; GO:0016772 "acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; hydrolase activity; mitochondrion; transferase activity, transferring phosphorus-containing groups" IPR006091; IPR009075; IPR013786; IPR009100; IPR002575; IPR023214; IPR006439; IPR011945; IPR011009; IPR023198; Acyl-CoA dehydrogenase family member 10 (ACAD-10) (EC 1.3.99.-) ACAD10 Homo sapiens (Human) TR35332_c0_g1_i3 P61583 NP8_HUMAN 5.00E-11 GO:0005634 nucleus HERV-K_3q12.3 provirus Np9 protein (Endogenous retrovirus K protein 5) (HERV-K(II) Np9 protein) ERVK-5 ERVK5 Homo sapiens (Human) TR35333_c0_g1_i1 Q0P466 TYW2_DANRE 1.00E-113 GO:0008168; GO:0008033 methyltransferase activity; tRNA processing IPR003402; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. tRNA wybutosine-synthesizing protein 2 homolog (tRNA-yW-synthesizing protein 2) (EC 2.1.1.-) (Alpha-amino-alpha-carboxypropyl transferase TYW2) (EC 2.5.1.-) trmt12 tyw2 zgc:153361 Danio rerio (Zebrafish) (Brachydanio rerio) TR35333_c0_g1_i2 Q4V8B8 TYW2_RAT 9.00E-103 GO:0008168; GO:0008033 methyltransferase activity; tRNA processing IPR003402; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. tRNA wybutosine-synthesizing protein 2 homolog (tRNA-yW-synthesizing protein 2) (EC 2.1.1.-) (Alpha-amino-alpha-carboxypropyl transferase TYW2) (EC 2.5.1.-) Trmt12 Tyw2 Rattus norvegicus (Rat) TR35336_c0_g1_i2 O65583 UKL4_ARATH 5.00E-55 GO:0005524; GO:0044211; GO:0005525; GO:0044206; GO:0016773; GO:0004845; GO:0004849 "ATP binding; CTP salvage; GTP binding; UMP salvage; phosphotransferase activity, alcohol group as acceptor; uracil phosphoribosyltransferase activity; uridine kinase activity" IPR027417; IPR006083; IPR000764; IPR026008; Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1. Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. Uridine kinase-like protein 4 [Includes: Uridine kinase (UK) (EC 2.7.1.48); Putative uracil phosphoribosyltransferase (UPRTase) (EC 2.4.2.9) (UMP pyrophosphorylase)] UKL4 UPT1 At4g26510 M3E9.60 Arabidopsis thaliana (Mouse-ear cress) TR35336_c0_g1_i3 Q6NYU7 UPP_DANRE 5.00E-107 GO:0005737; GO:0005634 cytoplasm; nucleus Uracil phosphoribosyltransferase homolog uprt zgc:77421 Danio rerio (Zebrafish) (Brachydanio rerio) TR35338_c0_g2_i1 P08635 SAST_RAT 2.00E-56 GO:0006633; GO:0016295; GO:0004320; GO:0016296 fatty acid biosynthetic process; myristoyl-[acyl-carrier-protein] hydrolase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity IPR012223; IPR001031; "S-acyl fatty acid synthase thioesterase, medium chain (EC 3.1.2.14) (Oleoyl-ACP hydrolase) (Thioesterase II) (Thioesterase domain-containing protein 1)" Olah Mch Thedc1 Rattus norvegicus (Rat) TR35338_c0_g2_i3 P08635 SAST_RAT 3.00E-58 GO:0006633; GO:0016295; GO:0004320; GO:0016296 fatty acid biosynthetic process; myristoyl-[acyl-carrier-protein] hydrolase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity IPR012223; IPR001031; "S-acyl fatty acid synthase thioesterase, medium chain (EC 3.1.2.14) (Oleoyl-ACP hydrolase) (Thioesterase II) (Thioesterase domain-containing protein 1)" Olah Mch Thedc1 Rattus norvegicus (Rat) TR35344_c0_g1_i1 Q00228 CYB_MYTED 0 GO:0009055; GO:0016021; GO:0046872; GO:0005743; GO:0016491; GO:0070469; GO:0022904 electron carrier activity; integral to membrane; metal ion binding; mitochondrial inner membrane; oxidoreductase activity; respiratory chain; respiratory electron transport chain IPR016175; IPR005798; IPR005797; IPR027387; IPR016174; Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit) MT-CYB COB CYTB MTCYB Mytilus edulis (Blue mussel) TR35348_c4_g1_i1 P05099 MATN1_CHICK 2.00E-28 GO:0005578 proteinaceous extracellular matrix IPR000742; IPR013032; IPR019466; IPR002035; Cartilage matrix protein (Matrilin-1) MATN1 CMP Gallus gallus (Chicken) TR35348_c4_g1_i2 Q91ZX1 C209A_MOUSE 1.00E-16 GO:0009986; GO:0006897; GO:0016021; GO:0005537; GO:0046872 cell surface; endocytosis; integral to membrane; mannose binding; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; CD209 antigen-like protein A (Dendritic cell-specific ICAM-3-grabbing non-integrin) (DC-SIGN) (CD antigen CD209) Cd209a Cire Mus musculus (Mouse) TR35348_c4_g1_i3 Q8C6K9 CO6A6_MOUSE 1.00E-21 GO:0007155; GO:0005581; GO:0031012 cell adhesion; collagen; extracellular matrix IPR008160; IPR002035; Collagen alpha-6(VI) chain Col6a6 Mus musculus (Mouse) TR35348_c4_g1_i4 Q95116 TSP2_BOVIN 4.00E-26 GO:0005509; GO:0007155; GO:0005576; GO:0008201 calcium ion binding; cell adhesion; extracellular region; heparin binding IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR024731; IPR001791; IPR000884; IPR015455; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-2 (Corticotropin-induced secreted protein) (CISP) THBS2 TSP-2 TSP2 Bos taurus (Bovine) TR35348_c5_g1_i1 A2BGL3 WSCD2_DANRE 2.00E-15 GO:0016021; GO:0008146 integral to membrane; sulfotransferase activity IPR027417; IPR000863; IPR002889; IPR013994; WSC domain-containing protein 2 wscd2 si:ch211-240b21.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR35350_c1_g1_i1 P53564 CUX1_MOUSE 4.00E-20 GO:0003677; GO:0001205; GO:0042491; GO:0003682; GO:0005737; GO:0001822; GO:0030324; GO:0000122; GO:0005634; GO:0043565 DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; auditory receptor cell differentiation; chromatin binding; cytoplasm; kidney development; lung development; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding IPR003350; IPR017970; IPR001356; IPR009057; IPR010982; Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein cux-1) Cux1 Cutl1 Cux Kiaa4047 Mus musculus (Mouse) TR35350_c1_g1_i3 P10180 CUT_DROME 3.00E-34 GO:0061332; GO:0048098; GO:0007417; GO:0070983; GO:0008585; GO:0060288; GO:0008587; GO:0000278; GO:0045746; GO:0000122; GO:0005634; GO:0030713; GO:0007422; GO:0007605; GO:0003700; GO:0035277; GO:0000976; GO:0006351 "Malpighian tubule bud morphogenesis; antennal joint development; central nervous system development; dendrite guidance; female gonad development; formation of a compartment boundary; imaginal disc-derived wing margin morphogenesis; mitotic cell cycle; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; ovarian follicle cell stalk formation; peripheral nervous system development; sensory perception of sound; sequence-specific DNA binding transcription factor activity; spiracle morphogenesis, open tracheal system; transcription regulatory region sequence-specific DNA binding; transcription, DNA-dependent" IPR003350; IPR017970; IPR001356; IPR009057; IPR010982; Homeobox protein cut ct CG11387 Drosophila melanogaster (Fruit fly) TR35350_c2_g1_i1 P10180 CUT_DROME 2.00E-17 GO:0061332; GO:0048098; GO:0007417; GO:0070983; GO:0008585; GO:0060288; GO:0008587; GO:0000278; GO:0045746; GO:0000122; GO:0005634; GO:0030713; GO:0007422; GO:0007605; GO:0003700; GO:0035277; GO:0000976; GO:0006351 "Malpighian tubule bud morphogenesis; antennal joint development; central nervous system development; dendrite guidance; female gonad development; formation of a compartment boundary; imaginal disc-derived wing margin morphogenesis; mitotic cell cycle; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; ovarian follicle cell stalk formation; peripheral nervous system development; sensory perception of sound; sequence-specific DNA binding transcription factor activity; spiracle morphogenesis, open tracheal system; transcription regulatory region sequence-specific DNA binding; transcription, DNA-dependent" IPR003350; IPR017970; IPR001356; IPR009057; IPR010982; Homeobox protein cut ct CG11387 Drosophila melanogaster (Fruit fly) TR35351_c0_g1_i2 Q01196 RUNX1_HUMAN 2.00E-58 GO:0005524; GO:0003677; GO:0005604; GO:0048266; GO:0005509; GO:0007417; GO:0060216; GO:0035162; GO:0031069; GO:0071425; GO:0001701; GO:0001889; GO:0030099; GO:0002318; GO:0030853; GO:0005634; GO:0048935; GO:0045766; GO:0030854; GO:2000872; GO:0045944; GO:0045893; GO:0046982; GO:0042803; GO:0071336; GO:0009966; GO:0000975; GO:0003700; GO:0001501; GO:0008134; GO:0006351 Q13951; Q00534; Q15723; P16371; Q9H2X6; P17542; Q04724 "ATP binding; DNA binding; basement membrane; behavioral response to pain; calcium ion binding; central nervous system development; definitive hemopoiesis; embryonic hemopoiesis; hair follicle morphogenesis; hematopoietic stem cell proliferation; in utero embryonic development; liver development; myeloid cell differentiation; myeloid progenitor cell differentiation; negative regulation of granulocyte differentiation; nucleus; peripheral nervous system neuron development; positive regulation of angiogenesis; positive regulation of granulocyte differentiation; positive regulation of progesterone secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein heterodimerization activity; protein homodimerization activity; regulation of hair follicle cell proliferation; regulation of signal transduction; regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; skeletal system development; transcription factor binding; transcription, DNA-dependent" IPR000040; IPR008967; IPR012346; IPR013524; IPR027384; IPR013711; IPR016554; Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) RUNX1 AML1 CBFA2 Homo sapiens (Human) TR35352_c0_g1_i1 Q9JLT4 TRXR2_MOUSE 0 GO:0050661; GO:0045454; GO:0050660; GO:0007507; GO:0030097; GO:0005739; GO:0000305; GO:0004791 NADP binding; cell redox homeostasis; flavin adenine dinucleotide binding; heart development; hemopoiesis; mitochondrion; response to oxygen radical; thioredoxin-disulfide reductase activity IPR016156; IPR013027; IPR004099; IPR023753; IPR012999; IPR001327; IPR006338; "Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Thioredoxin reductase TR3)" Txnrd2 Trxr2 Mus musculus (Mouse) TR35352_c0_g1_i2 O15770 GSHR_PLAF7 3.00E-44 GO:0045454; GO:0005737; GO:0050660; GO:0004362 cell redox homeostasis; cytoplasm; flavin adenine dinucleotide binding; glutathione-disulfide reductase activity IPR016156; IPR013027; IPR004099; IPR023753; IPR012999; IPR001327; Glutathione reductase (GR) (GRase) (EC 1.8.1.7) GR3 PF14_0192 Plasmodium falciparum (isolate 3D7) TR35352_c0_g1_i3 Q9NNW7 TRXR2_HUMAN 8.00E-140 GO:0050661; GO:0045454; GO:0050660; GO:0007507; GO:0030097; GO:0005739; GO:0000305; GO:0004791 NADP binding; cell redox homeostasis; flavin adenine dinucleotide binding; heart development; hemopoiesis; mitochondrion; response to oxygen radical; thioredoxin-disulfide reductase activity IPR016156; IPR013027; IPR004099; IPR023753; IPR012999; IPR001327; IPR006338; "Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Selenoprotein Z) (SelZ) (TR-beta) (Thioredoxin reductase TR3)" TXNRD2 KIAA1652 TRXR2 Homo sapiens (Human) TR35352_c0_g1_i4 P08655 YMER_STAAU 7.00E-13 GO:0045454; GO:0050660; GO:0016491 cell redox homeostasis; flavin adenine dinucleotide binding; oxidoreductase activity IPR016156; IPR004099; Uncharacterized 19.7 kDa protein in mercuric resistance operon Staphylococcus aureus TR35357_c2_g1_i1 Q4V8G0 LRC63_RAT 2.00E-12 IPR001611; IPR025875; Leucine-rich repeat-containing protein 63 Lrrc63 Rattus norvegicus (Rat) TR35357_c3_g1_i1 Q05C16 LRC63_HUMAN 9.00E-13 IPR001611; Leucine-rich repeat-containing protein 63 LRRC63 Homo sapiens (Human) TR35358_c0_g2_i1 Q6NRC9 LRCC1_XENLA 3.00E-40 GO:0051301; GO:0005814; GO:0007067 cell division; centriole; mitosis IPR001611; IPR025875; Leucine-rich repeat and coiled-coil domain-containing protein 1 lrrcc1 Xenopus laevis (African clawed frog) TR35358_c5_g1_i1 Q6NRC9 LRCC1_XENLA 7.00E-22 GO:0051301; GO:0005814; GO:0007067 cell division; centriole; mitosis IPR001611; IPR025875; Leucine-rich repeat and coiled-coil domain-containing protein 1 lrrcc1 Xenopus laevis (African clawed frog) TR35360_c1_g1_i1 Q99JY4 TRABD_MOUSE 9.00E-88 IPR002816; TraB domain-containing protein Trabd Mus musculus (Mouse) TR35362_c0_g1_i1 P08582 TRFM_HUMAN 9.00E-133 GO:0031225; GO:0006879; GO:0005576; GO:0008199; GO:0005887; GO:0005506; GO:0006826 anchored to membrane; cellular iron ion homeostasis; extracellular region; ferric iron binding; integral to plasma membrane; iron ion binding; iron ion transport IPR016357; IPR001156; IPR018195; Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228) MFI2 MAP97 Homo sapiens (Human) TR35363_c2_g1_i1 Q696W0 SPEG_DANRE 6.00E-24 GO:0005524; GO:0030018; GO:0007517; GO:0005634; GO:0004672; GO:0004674 ATP binding; Z disc; muscle organ development; nucleus; protein kinase activity; protein serine/threonine kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR020675; IPR000719; IPR017441; IPR002290; IPR015726; IPR008271; Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) speg apeg1 Danio rerio (Zebrafish) (Brachydanio rerio) TR35363_c2_g2_i2 Q9I7U4 TITIN_DROME 1.00E-34 GO:0030018; GO:0003779; GO:0051301; GO:0000794; GO:0040011; GO:0007498; GO:0005875; GO:0007076; GO:0016203; GO:0007520; GO:0035206; GO:0045214; GO:0007062; GO:0007519; GO:0007525; GO:0008307; GO:0007522 Z disc; actin binding; cell division; condensed nuclear chromosome; locomotion; mesoderm development; microtubule associated complex; mitotic chromosome condensation; muscle attachment; myoblast fusion; regulation of hemocyte proliferation; sarcomere organization; sister chromatid cohesion; skeletal muscle tissue development; somatic muscle development; structural constituent of muscle; visceral muscle development IPR010939; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR001452; Titin (D-Titin) (Kettin) sls titin CG1915 Drosophila melanogaster (Fruit fly) TR35363_c2_g5_i2 Q9I7U4 TITIN_DROME 1.00E-12 GO:0030018; GO:0003779; GO:0051301; GO:0000794; GO:0040011; GO:0007498; GO:0005875; GO:0007076; GO:0016203; GO:0007520; GO:0035206; GO:0045214; GO:0007062; GO:0007519; GO:0007525; GO:0008307; GO:0007522 Z disc; actin binding; cell division; condensed nuclear chromosome; locomotion; mesoderm development; microtubule associated complex; mitotic chromosome condensation; muscle attachment; myoblast fusion; regulation of hemocyte proliferation; sarcomere organization; sister chromatid cohesion; skeletal muscle tissue development; somatic muscle development; structural constituent of muscle; visceral muscle development IPR010939; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR001452; Titin (D-Titin) (Kettin) sls titin CG1915 Drosophila melanogaster (Fruit fly) TR35364_c0_g4_i1 Q08DG6 COX15_BOVIN 8.00E-100 GO:0006784; GO:0016021; GO:0005743; GO:0016627; GO:0008535 "heme a biosynthetic process; integral to membrane; mitochondrial inner membrane; oxidoreductase activity, acting on the CH-CH group of donors; respiratory chain complex IV assembly" IPR003780; IPR023754; IPR009003; Cytochrome c oxidase assembly protein COX15 homolog COX15 Bos taurus (Bovine) TR35366_c0_g2_i3 Q8BHA3 DTD2_MOUSE 2.00E-61 GO:0019478; GO:0005737; GO:0016788 "D-amino acid catabolic process; cytoplasm; hydrolase activity, acting on ester bonds" IPR023509; IPR003732; Probable D-tyrosyl-tRNA(Tyr) deacylase 2 (EC 3.1.-.-) (D-tyrosyl-tRNA deacylase 2) Dtd2 Mus musculus (Mouse) TR35368_c1_g1_i1 Q99676 ZN184_HUMAN 3.00E-124 GO:0003677; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 184 ZNF184 Homo sapiens (Human) TR35369_c0_g1_i1 Q5E9Q1 PGLT1_BOVIN 2.00E-147 GO:0035251; GO:0035252; GO:0072358; GO:0005788; GO:0006493; GO:0008593 UDP-glucosyltransferase activity; UDP-xylosyltransferase activity; cardiovascular system development; endoplasmic reticulum lumen; protein O-linked glycosylation; regulation of Notch signaling pathway IPR006598; Protein modification; protein glycosylation. Protein O-glucosyltransferase 1 (EC 2.4.1.-) (CAP10-like 46 kDa protein) (KTEL motif-containing protein 1) POGLUT1 CLP46 KTELC1 Bos taurus (Bovine) TR35370_c1_g1_i1 Q2KIX7 HP251_BOVIN 3.00E-07 GO:0005581 collagen IPR001073; IPR008160; IPR008983; Protein HP-25 homolog 1 Bos taurus (Bovine) TR35371_c0_g1_i1 P30974 TLR1_DROME 8.00E-21 GO:0004950; GO:0070098; GO:0006935; GO:0005887; GO:0004995 chemokine receptor activity; chemokine-mediated signaling pathway; chemotaxis; integral to plasma membrane; tachykinin receptor activity IPR000355; IPR000276; IPR017452; IPR001681; Tachykinin-like peptides receptor 86C (NKD) Takr86C NKD CG6515 Drosophila melanogaster (Fruit fly) TR35371_c0_g1_i2 O54799 NMBR_MOUSE 2.00E-43 GO:0004946; GO:0005737; GO:0016021; GO:0005886 bombesin receptor activity; cytoplasm; integral to membrane; plasma membrane IPR001556; IPR000276; IPR017452; IPR001642; Neuromedin-B receptor (NMB-R) (Neuromedin-B-preferring bombesin receptor) Nmbr Mus musculus (Mouse) TR35374_c3_g1_i1 Q96RW7 HMCN1_HUMAN 8.00E-13 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR35374_c3_g1_i2 A2AJ76 HMCN2_MOUSE 7.00E-10 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 Hmcn2 Mus musculus (Mouse) TR35374_c3_g1_i4 A2AJ76 HMCN2_MOUSE 9.00E-07 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 Hmcn2 Mus musculus (Mouse) TR35375_c0_g4_i1 O00566 MPP10_HUMAN 2.00E-27 GO:0000375; GO:0005694; GO:0010923; GO:0005730; GO:0006364; GO:0005732 P62136 "RNA splicing, via transesterification reactions; chromosome; negative regulation of phosphatase activity; nucleolus; rRNA processing; small nucleolar ribonucleoprotein complex" IPR007151; IPR012173; U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10) MPHOSPH10 MPP10 Homo sapiens (Human) TR35375_c0_g4_i2 O00566 MPP10_HUMAN 5.00E-55 GO:0000375; GO:0005694; GO:0010923; GO:0005730; GO:0006364; GO:0005732 P62136 "RNA splicing, via transesterification reactions; chromosome; negative regulation of phosphatase activity; nucleolus; rRNA processing; small nucleolar ribonucleoprotein complex" IPR007151; IPR012173; U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10) MPHOSPH10 MPP10 Homo sapiens (Human) TR35375_c0_g4_i3 P47083 MPP10_YEAST 1.00E-18 GO:0034457; GO:0000480; GO:0000447; GO:0000472; GO:0032040 P32899; P53941 "Mpp10 complex; endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); small-subunit processome" IPR007151; IPR012173; U3 small nucleolar RNA-associated protein MPP10 (U3 snoRNA-associated protein MPP10) (M phase phosphoprotein 10) MPP10 YJR002W J1411 YJR83.5 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR35376_c0_g1_i5 Q96JK4 HIPL1_HUMAN 0 GO:0005975; GO:0005576; GO:0016020; GO:0016901; GO:0048038; GO:0005044 "carbohydrate metabolic process; extracellular region; membrane; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor; quinone binding; scavenger receptor activity" IPR011042; IPR018143; IPR012938; IPR011041; IPR001190; IPR017448; HHIP-like protein 1 HHIPL1 HHIP2 KIAA1822 UNQ9245/PRO34761 Homo sapiens (Human) TR35376_c0_g1_i6 Q6UWX4 HIPL2_HUMAN 0 GO:0005975; GO:0005576; GO:0016901; GO:0048038 "carbohydrate metabolic process; extracellular region; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor; quinone binding" IPR011042; IPR018143; IPR012938; IPR011041; HHIP-like protein 2 HHIPL2 HHIP3 KIAA1822L UNQ841/PRO1779 Homo sapiens (Human) TR35376_c0_g1_i7 Q96JK4 HIPL1_HUMAN 0 GO:0005975; GO:0005576; GO:0016020; GO:0016901; GO:0048038; GO:0005044 "carbohydrate metabolic process; extracellular region; membrane; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor; quinone binding; scavenger receptor activity" IPR011042; IPR018143; IPR012938; IPR011041; IPR001190; IPR017448; HHIP-like protein 1 HHIPL1 HHIP2 KIAA1822 UNQ9245/PRO34761 Homo sapiens (Human) TR35380_c4_g2_i1 Q978Y8 SYW_THEVO 7.00E-15 GO:0005524; GO:0005737; GO:0004830; GO:0006436 ATP binding; cytoplasm; tryptophan-tRNA ligase activity; tryptophanyl-tRNA aminoacylation IPR002305; IPR014729; IPR002306; IPR020653; Tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) trpS TV1276 TVG1316213 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) TR35380_c4_g2_i2 P17248 SYWC_BOVIN 0 GO:0005524; GO:0005737; GO:0045765; GO:0004830; GO:0006436 ATP binding; cytoplasm; regulation of angiogenesis; tryptophan-tRNA ligase activity; tryptophanyl-tRNA aminoacylation IPR001412; IPR002305; IPR014729; IPR009068; IPR002306; IPR000738; "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" WARS Bos taurus (Bovine) TR35381_c0_g1_i1 Q9EPQ1 TLR1_MOUSE 8.00E-18 GO:0002755; GO:0035354; GO:0007250; GO:0071727; GO:0006952; GO:0042495; GO:0006954; GO:0045087; GO:0016021; GO:0042116; GO:0016020; GO:0045335; GO:0030670; GO:0045410; GO:0042535; GO:0050707; GO:0034130; GO:0004888; GO:0042497 MyD88-dependent toll-like receptor signaling pathway; Toll-like receptor 1-Toll-like receptor 2 protein complex; activation of NF-kappaB-inducing kinase activity; cellular response to triacyl bacterial lipopeptide; defense response; detection of triacyl bacterial lipopeptide; inflammatory response; innate immune response; integral to membrane; macrophage activation; membrane; phagocytic vesicle; phagocytic vesicle membrane; positive regulation of interleukin-6 biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; regulation of cytokine secretion; toll-like receptor 1 signaling pathway; transmembrane signaling receptor activity; triacyl lipopeptide binding IPR000483; IPR001611; IPR025875; IPR000157; IPR027190; IPR017241; Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) Tlr1 Mus musculus (Mouse) TR35381_c0_g1_i4 Q689D1 TLR2_CANFA 2.00E-15 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Canis familiaris (Dog) (Canis lupus familiaris) TR35383_c6_g1_i1 Q94KI8 TPC1_ARATH 3.00E-14 GO:0005794; GO:0005509; GO:0019722; GO:0016021; GO:0000325; GO:0005886; GO:0080141; GO:0010119; GO:0009845; GO:0005774; GO:0005245 Golgi apparatus; calcium ion binding; calcium-mediated signaling; integral to membrane; plant-type vacuole; plasma membrane; regulation of jasmonic acid biosynthetic process; regulation of stomatal movement; seed germination; vacuolar membrane; voltage-gated calcium channel activity IPR027359; IPR011992; IPR002048; IPR005821; Two pore calcium channel protein 1 (Calcium channel protein 1) (AtCCH1) (Fatty acid oxygenation up-regulated protein 2) (Voltage-dependent calcium channel protein TPC1) (AtTPC1) TPC1 CCH1 FOU2 At4g03560 F9H3.19 T5L23.5 Arabidopsis thaliana (Mouse-ear cress) TR35386_c0_g1_i2 Q6INR1 EIF3J_XENLA 2.00E-24 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0006446; GO:0003743 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; regulation of translational initiation; translation initiation factor activity IPR023194; IPR013906; Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35) eif3j eif3s1 Xenopus laevis (African clawed frog) TR35386_c0_g1_i3 Q7SXU0 EI3JA_DANRE 7.00E-28 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0006446; GO:0003743 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; regulation of translational initiation; translation initiation factor activity IPR023194; IPR013906; Eukaryotic translation initiation factor 3 subunit J-A (eIF3j-A) (Eukaryotic translation initiation factor 3 subunit 1-A) (eIF-3-alpha-A) (eIF3 p35-A) eif3ja eif3j eif3s1a zgc:63801 Danio rerio (Zebrafish) (Brachydanio rerio) TR35386_c0_g1_i4 Q7SXU0 EI3JA_DANRE 7.00E-28 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0006446; GO:0003743 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; regulation of translational initiation; translation initiation factor activity IPR023194; IPR013906; Eukaryotic translation initiation factor 3 subunit J-A (eIF3j-A) (Eukaryotic translation initiation factor 3 subunit 1-A) (eIF-3-alpha-A) (eIF3 p35-A) eif3ja eif3j eif3s1a zgc:63801 Danio rerio (Zebrafish) (Brachydanio rerio) TR35388_c0_g1_i1 Q32LG3 MDHM_BOVIN 4.00E-149 GO:0030060; GO:0044262; GO:0006475; GO:0006108; GO:0005759; GO:0006099 L-malate dehydrogenase activity; cellular carbohydrate metabolic process; internal protein amino acid acetylation; malate metabolic process; mitochondrial matrix; tricarboxylic acid cycle IPR001557; IPR022383; IPR001236; IPR015955; IPR001252; IPR010097; IPR016040; "Malate dehydrogenase, mitochondrial (EC 1.1.1.37)" MDH2 Bos taurus (Bovine) TR35388_c0_g1_i2 P08249 MDHM_MOUSE 6.00E-23 GO:0030060; GO:0006734; GO:0044262; GO:0006475; GO:0046554; GO:0006108; GO:0005743; GO:0005759; GO:0006107; GO:0006099 L-malate dehydrogenase activity; NADH metabolic process; cellular carbohydrate metabolic process; internal protein amino acid acetylation; malate dehydrogenase (NADP+) activity; malate metabolic process; mitochondrial inner membrane; mitochondrial matrix; oxaloacetate metabolic process; tricarboxylic acid cycle IPR001557; IPR022383; IPR001236; IPR015955; IPR001252; IPR010097; IPR016040; "Malate dehydrogenase, mitochondrial (EC 1.1.1.37)" Mdh2 Mor1 Mus musculus (Mouse) TR35389_c0_g1_i1 P43119 PI2R_HUMAN 3.00E-27 GO:0004930; GO:0007189; GO:0007596; GO:0007267; GO:0005829; GO:0005085; GO:0005887; GO:0010642; GO:0048662; GO:0030819; GO:0043950; GO:0032496 G-protein coupled receptor activity; adenylate cyclase-activating G-protein coupled receptor signaling pathway; blood coagulation; cell-cell signaling; cytosol; guanyl-nucleotide exchange factor activity; integral to plasma membrane; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of smooth muscle cell proliferation; positive regulation of cAMP biosynthetic process; positive regulation of cAMP-mediated signaling; response to lipopolysaccharide IPR000276; IPR017452; IPR008365; IPR000370; Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor) PTGIR PRIPR Homo sapiens (Human) TR35389_c0_g1_i2 Q95KZ0 PE2R4_PANTR 2.00E-36 GO:0042093; GO:0007188; GO:0071260; GO:0016021; GO:0050710; GO:2000420; GO:0050728; GO:0033624; GO:0005886; GO:0050715; GO:0050729; GO:0004957; GO:0030278; GO:0051492; GO:0032496 T-helper cell differentiation; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; cellular response to mechanical stimulus; integral to membrane; negative regulation of cytokine secretion; negative regulation of eosinophil extravasation; negative regulation of inflammatory response; negative regulation of integrin activation; plasma membrane; positive regulation of cytokine secretion; positive regulation of inflammatory response; prostaglandin E receptor activity; regulation of ossification; regulation of stress fiber assembly; response to lipopolysaccharide IPR000276; IPR017452; IPR001758; IPR008365; IPR001244; Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 Pan troglodytes (Chimpanzee) TR3539_c1_g1_i1 Q14643 ITPR1_HUMAN 1.00E-57 GO:0038095; GO:0038096; GO:0007202; GO:0005955; GO:0032469; GO:0005789; GO:0006112; GO:0007173; GO:0008543; GO:0045087; GO:0005220; GO:0016021; GO:0005218; GO:0070059; GO:0048011; GO:0005637; GO:0005730; GO:0035091; GO:0030168; GO:0031088; GO:0031095; GO:0009791; GO:0014069; GO:0050796; GO:0051209; GO:0001666; GO:0016529; GO:0044281; GO:0050882 "Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; activation of phospholipase C activity; calcineurin complex; endoplasmic reticulum calcium ion homeostasis; endoplasmic reticulum membrane; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; integral to membrane; intracellular ligand-gated calcium channel activity; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; neurotrophin TRK receptor signaling pathway; nuclear inner membrane; nucleolus; phosphatidylinositol binding; platelet activation; platelet dense granule membrane; platelet dense tubular network membrane; post-embryonic development; postsynaptic density; regulation of insulin secretion; release of sequestered calcium ion into cytosol; response to hypoxia; sarcoplasmic reticulum; small molecule metabolic process; voluntary musculoskeletal movement" IPR016024; IPR000699; IPR014821; IPR000493; IPR005821; IPR016093; IPR013662; IPR015925; "Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)" ITPR1 INSP3R1 Homo sapiens (Human) TR35390_c1_g1_i1 Q28ER3 BIR52_XENTR 6.00E-09 GO:0051301; GO:0032133; GO:0007059; GO:0000777; GO:0005737; GO:0046872; GO:0030496; GO:0007067; GO:0043066; GO:0045892; GO:0005634; GO:0006468; GO:0046965; GO:0005819; GO:0001944 "cell division; chromosome passenger complex; chromosome segregation; condensed chromosome kinetochore; cytoplasm; metal ion binding; midbody; mitosis; negative regulation of apoptotic process; negative regulation of transcription, DNA-dependent; nucleus; protein phosphorylation; retinoid X receptor binding; spindle; vasculature development" IPR001370; Baculoviral IAP repeat-containing protein 5.2 (Survivin 2) (Survivin) birc5.2 TGas042b13.1 TGas101d21.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35390_c1_g1_i2 P41437 IAP3_NPVOP 5.00E-08 GO:0006915; GO:0016874; GO:0039648; GO:0008270 apoptotic process; ligase activity; modulation by virus of host protein ubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; E3 ubiquitin-protein ligase IAP-3 (EC 6.3.2.-) (IAP-3) IAP3 IAP ORF35 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) TR35390_c1_g1_i3 O70201 BIRC5_MOUSE 2.00E-06 GO:0000086; GO:0005814; GO:0032133; GO:0007059; GO:0048037; GO:0000777; GO:0043027; GO:0000910; GO:0005881; GO:0005829; GO:0009790; GO:0051303; GO:0031021; GO:0008017; GO:0000226; GO:0030496; GO:0007067; GO:0043524; GO:0045892; GO:0005634; GO:0031536; GO:0045931; GO:0031503; GO:0042803; GO:0006468; GO:0061178; GO:0061469; GO:0031577; GO:0005876; GO:0006351; GO:0008270 "G2/M transition of mitotic cell cycle; centriole; chromosome passenger complex; chromosome segregation; cofactor binding; condensed chromosome kinetochore; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytokinesis; cytoplasmic microtubule; cytosol; embryo development; establishment of chromosome localization; interphase microtubule organizing center; microtubule binding; microtubule cytoskeleton organization; midbody; mitosis; negative regulation of neuron apoptotic process; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of exit from mitosis; positive regulation of mitotic cell cycle; protein complex localization; protein homodimerization activity; protein phosphorylation; regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of type B pancreatic cell proliferation; spindle checkpoint; spindle microtubule; transcription, DNA-dependent; zinc ion binding" IPR001370; Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) (TIAP) Birc5 Api4 Iap4 Mus musculus (Mouse) TR35390_c2_g1_i1 Q24307 IAP2_DROME 2.00E-17 GO:0050829; GO:0043066; GO:0043154; GO:0061057; GO:0006964; GO:0033160; GO:0070534; GO:0007423; GO:0008270 "defense response to Gram-negative bacterium; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; peptidoglycan recognition protein signaling pathway; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; positive regulation of protein import into nucleus, translocation; protein K63-linked ubiquitination; sensory organ development; zinc ion binding" IPR001370; IPR001841; IPR013083; Apoptosis 2 inhibitor (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) (dIAP2) Iap2 DIHA ILP CG8293 Drosophila melanogaster (Fruit fly) TR35390_c2_g1_i2 Q8WY64 MYLIP_HUMAN 2.00E-10 GO:0006928; GO:0042632; GO:0005737; GO:0008092; GO:0005856; GO:0019898; GO:0005622; GO:0010989; GO:0007399; GO:0005886; GO:0045732; GO:0031648; GO:0042787; GO:0032803; GO:0004842; GO:0008270 cellular component movement; cholesterol homeostasis; cytoplasm; cytoskeletal protein binding; cytoskeleton; extrinsic to membrane; intracellular; negative regulation of low-density lipoprotein particle clearance; nervous system development; plasma membrane; positive regulation of protein catabolic process; protein destabilization; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of low-density lipoprotein particle receptor catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR019749; IPR019750; IPR000798; IPR014352; IPR019748; IPR000299; IPR018979; IPR011993; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MYLIP (EC 6.3.2.-) (Inducible degrader of the LDL-receptor) (Idol) (Myosin regulatory light chain interacting protein) (MIR) MYLIP BZF1 IDOL BM-023 PP5242 Homo sapiens (Human) TR35390_c2_g1_i3 O62640 PIAP_PIG 4.00E-18 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR35390_c2_g1_i5 Q557E7 CBLA_DICDI 1.00E-07 GO:0005509; GO:0005829; GO:0007243; GO:0016874; GO:0005634; GO:0016567; GO:0030587; GO:0008270 calcium ion binding; cytosol; intracellular protein kinase cascade; ligase activity; nucleus; protein ubiquitination; sorocarp development; zinc ion binding IPR014741; IPR024159; IPR011992; IPR000980; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase cblA (EC 6.3.2.-) (Cbl-like protein A) (RING finger protein cblA) cblA-1 DDB_G0273141; cblA-2 DDB_G0273609 Dictyostelium discoideum (Slime mold) TR35390_c2_g3_i1 Q96CA5 BIRC7_HUMAN 8.00E-20 GO:0005794; GO:0007257; GO:0006309; GO:0004869; GO:0019899; GO:0043066; GO:0005634; GO:0042127; GO:0070247; GO:0004842; GO:0008270 P55211; Q9NR28; O43464 Golgi apparatus; activation of JUN kinase activity; apoptotic DNA fragmentation; cysteine-type endopeptidase inhibitor activity; enzyme binding; negative regulation of apoptotic process; nucleus; regulation of cell proliferation; regulation of natural killer cell apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; IPR017907; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)] BIRC7 KIAP LIVIN MLIAP RNF50 UNQ5800/PRO19607/PRO21344 Homo sapiens (Human) TR35390_c2_g3_i4 O10296 IAP1_NPVOP 1.00E-10 GO:0006915; GO:0008270 apoptotic process; zinc ion binding IPR001370; IPR001841; IPR013083; Apoptosis inhibitor 1 (IAP-1) IAP1 ORF41 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) TR35390_c2_g3_i5 Q24307 IAP2_DROME 5.00E-21 GO:0050829; GO:0043066; GO:0043154; GO:0061057; GO:0006964; GO:0033160; GO:0070534; GO:0007423; GO:0008270 "defense response to Gram-negative bacterium; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; peptidoglycan recognition protein signaling pathway; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; positive regulation of protein import into nucleus, translocation; protein K63-linked ubiquitination; sensory organ development; zinc ion binding" IPR001370; IPR001841; IPR013083; Apoptosis 2 inhibitor (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) (dIAP2) Iap2 DIHA ILP CG8293 Drosophila melanogaster (Fruit fly) TR35391_c2_g1_i1 Q04545 TDA9_YEAST 2.00E-06 GO:0046872; GO:0005634; GO:0006355; GO:0043565; GO:0006351 "metal ion binding; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Probable transcription factor TDA9 (Topoisomerase I damage affected protein 9) TDA9 YML081W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR35391_c2_g2_i1 Q8TAX0 OSR1_HUMAN 4.00E-50 GO:0071300; GO:0002062; GO:0042733; GO:0035115; GO:0035116; GO:0036023; GO:0008406; GO:0007507; GO:0048389; GO:0072143; GO:0072180; GO:0046872; GO:0090094; GO:0072239; GO:0072259; GO:0072162; GO:0072234; GO:0072208; GO:0042474; GO:0043066; GO:0072183; GO:0000122; GO:0003676; GO:0005730; GO:0042476; GO:0060021; GO:0072268; GO:0030501; GO:0050679; GO:2000543; GO:0045944; GO:0048793; GO:0072184; GO:0072168; GO:0072169; GO:0006351; GO:0072190; GO:0001657 "cellular response to retinoic acid; chondrocyte differentiation; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic skeletal limb joint morphogenesis; gonad development; heart development; intermediate mesoderm development; mesangial cell development; mesonephric duct morphogenesis; metal ion binding; metanephric cap mesenchymal cell proliferation involved in metanephros development; metanephric glomerulus vasculature development; metanephric interstitial cell development; metanephric mesenchymal cell differentiation; metanephric nephron tubule development; metanephric smooth muscle tissue development; middle ear morphogenesis; negative regulation of apoptotic process; negative regulation of nephron tubule epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; nucleic acid binding; nucleolus; odontogenesis; palate development; pattern specification involved in metanephros development; positive regulation of bone mineralization; positive regulation of epithelial cell proliferation; positive regulation of gastrulation; positive regulation of transcription from RNA polymerase II promoter; pronephros development; renal vesicle progenitor cell differentiation; specification of anterior mesonephric tubule identity; specification of posterior mesonephric tubule identity; transcription, DNA-dependent; ureter urothelium development; ureteric bud development" IPR007087; IPR015880; IPR013087; Protein odd-skipped-related 1 OSR1 ODD Homo sapiens (Human) TR35391_c2_g3_i1 Q7PN68 DRM_ANOGA 2.00E-13 GO:0003677; GO:0046872; GO:0005634; GO:0007366; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; periodic partitioning by pair rule gene; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Protein drumstick drm AGAP007974 Anopheles gambiae (African malaria mosquito) TR35392_c1_g1_i2 Q03920 MTQ2_YEAST 4.00E-21 GO:0008757; GO:0005737; GO:0035657; GO:0003676; GO:0005634; GO:0018364; GO:0008276; GO:0006417 P53738 S-adenosylmethionine-dependent methyltransferase activity; cytoplasm; eRF1 methyltransferase complex; nucleic acid binding; nucleus; peptidyl-glutamine methylation; protein methyltransferase activity; regulation of translation IPR002052; IPR004557; eRF1 methyltransferase catalytic subunit MTQ2 (eRF1 MTase catalytic subunit MTQ2) (EC 2.1.1.-) (N(5)-glutamine methyltransferase MTQ2) MTQ2 MTC6 YDR140W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR35392_c1_g1_i3 Q9UT94 MTQ2_SCHPO 6.00E-26 GO:0008757; GO:0005829; GO:0035657; GO:0003676; GO:0005634; GO:0006479; GO:0008276; GO:2000765 S-adenosylmethionine-dependent methyltransferase activity; cytosol; eRF1 methyltransferase complex; nucleic acid binding; nucleus; protein methylation; protein methyltransferase activity; regulation of cytoplasmic translation IPR002052; IPR004557; eRF1 methyltransferase catalytic subunit mtq2 (eRF1 MTase catalytic subunit mtq2) (EC 2.1.1.-) (N(5)-glutamine methyltransferase catalytic subunit mtq2) mtq2 SPAC323.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR35392_c1_g1_i4 Q9Y5N5 HEMK2_HUMAN 6.00E-67 GO:0003676; GO:0030307; GO:0043234; GO:0008276 nucleic acid binding; positive regulation of cell growth; protein complex; protein methyltransferase activity IPR002052; IPR004557; HemK methyltransferase family member 2 (EC 2.1.1.-) (M.HsaHemK2P) (N(6)-adenine-specific DNA methyltransferase 1) N6AMT1 C21orf127 HEMK2 PRED28 Homo sapiens (Human) TR35393_c0_g1_i1 Q9HH99 P5CR_METAC 5.00E-66 GO:0055129; GO:0005737; GO:0004735 L-proline biosynthetic process; cytoplasm; pyrroline-5-carboxylate reductase activity IPR008927; IPR016040; IPR000304; Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. Pyrroline-5-carboxylate reductase (P5C reductase) (P5CR) (EC 1.5.1.2) proC MA_4102 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) TR35393_c0_g1_i3 Q58DT4 P5CR1_BOVIN 1.00E-66 GO:0055129; GO:0034599; GO:0005739; GO:0006561; GO:0004735 L-proline biosynthetic process; cellular response to oxidative stress; mitochondrion; proline biosynthetic process; pyrroline-5-carboxylate reductase activity IPR008927; IPR016040; IPR000304; Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. "Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2)" PYCR1 Bos taurus (Bovine) TR35394_c0_g1_i1 Q9DEE9 ARP6_CHICK 1.00E-169 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR004000; Actin-related protein 6 (gArp6) (gARPX) ACTR6 Gallus gallus (Chicken) TR35394_c0_g1_i2 Q9DEE9 ARP6_CHICK 9.00E-170 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR004000; Actin-related protein 6 (gArp6) (gARPX) ACTR6 Gallus gallus (Chicken) TR35395_c2_g1_i1 Q503Q1 MIEAP_DANRE 5.00E-75 GO:0005741; GO:0035694; GO:0035695; GO:0006974 mitochondrial outer membrane; mitochondrial protein catabolic process; mitochondrion degradation by induced vacuole formation; response to DNA damage stimulus IPR026169; Mitochondria-eating protein (Spermatogenesis-associated protein 18) spata18 mieap si:ch73-16a12.2 zgc:110352 Danio rerio (Zebrafish) (Brachydanio rerio) TR35395_c2_g2_i3 Q6AYL6 MIEAP_RAT 4.00E-37 GO:0030154; GO:0005741; GO:0035694; GO:0035695; GO:0007275; GO:0006974; GO:0007283 cell differentiation; mitochondrial outer membrane; mitochondrial protein catabolic process; mitochondrion degradation by induced vacuole formation; multicellular organismal development; response to DNA damage stimulus; spermatogenesis IPR026169; Mitochondria-eating protein (Spermatid-expressing gene 1 protein) (Spetex-1) (Spermatogenesis-associated protein 18) Spata18 Mieap Spetex1 Rattus norvegicus (Rat) TR35397_c3_g1_i1 O35245 PKD2_MOUSE 2.00E-112 GO:0007259; GO:0035904; GO:0045180; GO:0009925; GO:0001658; GO:0005262; GO:0005509; GO:0048763; GO:0007050; GO:0071498; GO:0071464; GO:0071470; GO:0042994; GO:0050982; GO:0003127; GO:0071910; GO:0001892; GO:0005783; GO:0031941; GO:0007507; GO:0001947; GO:0071458; GO:0071556; GO:0005887; GO:0001822; GO:0030027; GO:0001889; GO:0072177; GO:0072284; GO:0072218; GO:0072214; GO:0072219; GO:0072235; GO:0072075; GO:0035502; GO:0072208; GO:0005932; GO:0072686; GO:0031512; GO:2000134; GO:0060315; GO:0021915; GO:0031513; GO:0060674; GO:0005886; GO:0002133; GO:0071158; GO:0031659; GO:0010628; GO:0031587; GO:0045429; GO:0045944; GO:0005267; GO:0030814; GO:0090279; GO:0042127; GO:0051209; GO:0061441; GO:0061333; GO:0021510; GO:0005245; GO:0005248 "JAK-STAT cascade; aorta development; basal cortex; basal plasma membrane; branching involved in ureteric bud morphogenesis; calcium channel activity; calcium ion binding; calcium-induced calcium release activity; cell cycle arrest; cellular response to fluid shear stress; cellular response to hydrostatic pressure; cellular response to osmotic stress; cytoplasmic sequestering of transcription factor; detection of mechanical stimulus; detection of nodal flow; determination of liver left/right asymmetry; embryonic placenta development; endoplasmic reticulum; filamentous actin; heart development; heart looping; integral to cytosolic side of endoplasmic reticulum membrane; integral to lumenal side of endoplasmic reticulum membrane; integral to plasma membrane; kidney development; lamellipodium; liver development; mesonephric duct development; metanephric S-shaped body morphogenesis; metanephric ascending thin limb development; metanephric cortex development; metanephric cortical collecting duct development; metanephric distal tubule development; metanephric mesenchyme development; metanephric part of ureteric bud development; metanephric smooth muscle tissue development; microtubule basal body; mitotic spindle; motile primary cilium; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of ryanodine-sensitive calcium-release channel activity; neural tube development; nonmotile primary cilium; placenta blood vessel development; plasma membrane; polycystin complex; positive regulation of cell cycle arrest; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; positive regulation of nitric oxide biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; potassium channel activity; regulation of cAMP metabolic process; regulation of calcium ion import; regulation of cell proliferation; release of sequestered calcium ion into cytosol; renal artery morphogenesis; renal tubule morphogenesis; spinal cord development; voltage-gated calcium channel activity; voltage-gated sodium channel activity" IPR027359; IPR011992; IPR002048; IPR013122; IPR003915; Polycystin-2 (Polycystic kidney disease 2 protein homolog) Pkd2 Mus musculus (Mouse) TR35397_c3_g1_i2 Q4GZT3 PKD2_BOVIN 8.00E-116 GO:0007259; GO:0035904; GO:0045180; GO:0009925; GO:0001658; GO:0005262; GO:0005509; GO:0048763; GO:0007050; GO:0005911; GO:0071498; GO:0071464; GO:0071470; GO:0042994; GO:0050982; GO:0003127; GO:0071910; GO:0001892; GO:0031941; GO:0001947; GO:0071458; GO:0071556; GO:0005887; GO:0030027; GO:0016020; GO:0072177; GO:0072284; GO:0072218; GO:0072214; GO:0072219; GO:0072235; GO:0072075; GO:0035502; GO:0072208; GO:0005932; GO:0072686; GO:0031512; GO:2000134; GO:0060315; GO:0021915; GO:0031513; GO:0060674; GO:0002133; GO:0071158; GO:0031659; GO:0031587; GO:0045429; GO:0045944; GO:0005267; GO:0030814; GO:0090279; GO:0042127; GO:0051209; GO:0061441; GO:0061333; GO:0021510; GO:0005245; GO:0005248 "JAK-STAT cascade; aorta development; basal cortex; basal plasma membrane; branching involved in ureteric bud morphogenesis; calcium channel activity; calcium ion binding; calcium-induced calcium release activity; cell cycle arrest; cell-cell junction; cellular response to fluid shear stress; cellular response to hydrostatic pressure; cellular response to osmotic stress; cytoplasmic sequestering of transcription factor; detection of mechanical stimulus; detection of nodal flow; determination of liver left/right asymmetry; embryonic placenta development; filamentous actin; heart looping; integral to cytosolic side of endoplasmic reticulum membrane; integral to lumenal side of endoplasmic reticulum membrane; integral to plasma membrane; lamellipodium; membrane; mesonephric duct development; metanephric S-shaped body morphogenesis; metanephric ascending thin limb development; metanephric cortex development; metanephric cortical collecting duct development; metanephric distal tubule development; metanephric mesenchyme development; metanephric part of ureteric bud development; metanephric smooth muscle tissue development; microtubule basal body; mitotic spindle; motile primary cilium; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of ryanodine-sensitive calcium-release channel activity; neural tube development; nonmotile primary cilium; placenta blood vessel development; polycystin complex; positive regulation of cell cycle arrest; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; positive regulation of nitric oxide biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; potassium channel activity; regulation of cAMP metabolic process; regulation of calcium ion import; regulation of cell proliferation; release of sequestered calcium ion into cytosol; renal artery morphogenesis; renal tubule morphogenesis; spinal cord development; voltage-gated calcium channel activity; voltage-gated sodium channel activity" IPR027359; IPR011992; IPR002048; IPR013122; IPR003915; Polycystin-2 (Polycystic kidney disease 2 protein homolog) PKD2 Bos taurus (Bovine) TR35397_c3_g1_i3 Q9P0L9 PK2L1_HUMAN 2.00E-108 GO:0005262; GO:0005509; GO:0015269; GO:0009986; GO:0071468; GO:0001581; GO:0050982; GO:0005783; GO:0042802; GO:0016021; GO:0005886; GO:0005272; GO:0033040 calcium channel activity; calcium ion binding; calcium-activated potassium channel activity; cell surface; cellular response to acidity; detection of chemical stimulus involved in sensory perception of sour taste; detection of mechanical stimulus; endoplasmic reticulum; identical protein binding; integral to membrane; plasma membrane; sodium channel activity; sour taste receptor activity IPR011992; IPR013122; IPR003915; Polycystic kidney disease 2-like 1 protein (Polycystin-2 homolog) (Polycystin-2L1) (Polycystin-L) (Polycystin-L1) PKD2L1 PKD2L PKDL Homo sapiens (Human) TR35397_c3_g1_i6 Q9P0L9 PK2L1_HUMAN 0 GO:0005262; GO:0005509; GO:0015269; GO:0009986; GO:0071468; GO:0001581; GO:0050982; GO:0005783; GO:0042802; GO:0016021; GO:0005886; GO:0005272; GO:0033040 calcium channel activity; calcium ion binding; calcium-activated potassium channel activity; cell surface; cellular response to acidity; detection of chemical stimulus involved in sensory perception of sour taste; detection of mechanical stimulus; endoplasmic reticulum; identical protein binding; integral to membrane; plasma membrane; sodium channel activity; sour taste receptor activity IPR011992; IPR013122; IPR003915; Polycystic kidney disease 2-like 1 protein (Polycystin-2 homolog) (Polycystin-2L1) (Polycystin-L) (Polycystin-L1) PKD2L1 PKD2L PKDL Homo sapiens (Human) TR35399_c0_g1_i3 Q9WU62 INCE_MOUSE 1.00E-21 GO:0000801; GO:0005721; GO:0010369; GO:0007059; GO:0000777; GO:0000910; GO:0005737; GO:0000776; GO:0000800; GO:0005874; GO:0030496; GO:0007067; GO:0005819 central element; centromeric heterochromatin; chromocenter; chromosome segregation; condensed chromosome kinetochore; cytokinesis; cytoplasm; kinetochore; lateral element; microtubule; midbody; mitosis; spindle IPR022006; IPR005635; Inner centromere protein Incenp Mus musculus (Mouse) TR35401_c1_g1_i1 Q16609 LPAL2_HUMAN 2.00E-14 GO:0005576 extracellular region IPR000001; IPR013806; IPR018056; Putative apolipoprotein(a)-like protein 2 (Apo(a)-like protein 2) (Lp(a)-liker protein 2) (Apolipoprotein a-related gene C protein) (Apo(a)rg-C) LPAL2 APOARGC Homo sapiens (Human) TR35403_c2_g2_i1 Q29RI9 MAT2B_BOVIN 6.00E-98 GO:0006556; GO:0008831; GO:0045226; GO:0048269; GO:0048270; GO:0005739; GO:0005634; GO:0006730 S-adenosylmethionine biosynthetic process; dTDP-4-dehydrorhamnose reductase activity; extracellular polysaccharide biosynthetic process; methionine adenosyltransferase complex; methionine adenosyltransferase regulator activity; mitochondrion; nucleus; one-carbon metabolic process IPR005913; IPR016040; Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) MAT2B Bos taurus (Bovine) TR35403_c2_g2_i2 Q5BJJ6 MAT2B_DANRE 6.00E-83 GO:0006556; GO:0008831; GO:0045226; GO:0006730 S-adenosylmethionine biosynthetic process; dTDP-4-dehydrorhamnose reductase activity; extracellular polysaccharide biosynthetic process; one-carbon metabolic process IPR005913; IPR016040; Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) mat2b zgc:110308 Danio rerio (Zebrafish) (Brachydanio rerio) TR35403_c2_g2_i3 P71052 EPSC_BACSU 3.00E-06 GO:0016021; GO:0005886; GO:0000271 integral to membrane; plasma membrane; polysaccharide biosynthetic process IPR016040; IPR003869; Probable polysaccharide biosynthesis protein EpsC epsC yveM BSU34350 Bacillus subtilis (strain 168) TR35403_c2_g2_i4 Q5U2R0 MAT2B_RAT 3.00E-96 GO:0006556; GO:0008831; GO:0045226; GO:0006730 S-adenosylmethionine biosynthetic process; dTDP-4-dehydrorhamnose reductase activity; extracellular polysaccharide biosynthetic process; one-carbon metabolic process IPR005913; IPR016040; Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) Mat2b Rattus norvegicus (Rat) TR35404_c1_g1_i1 G5E8K5 ANK3_MOUSE 4.00E-10 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR35404_c2_g1_i1 P21329 RTJK_DROFU 3.00E-10 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) TR35408_c11_g1_i1 Q6YHK3 CD109_HUMAN 4.00E-15 GO:0031225; GO:0005615; GO:0010951; GO:0005886; GO:0004867 anchored to membrane; extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) TR35408_c8_g3_i1 Q8IZJ3 CPMD8_HUMAN 5.00E-59 GO:0005615; GO:0010951; GO:0005886; GO:0004867 extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR002350; IPR001599; IPR019742; IPR019565; IPR022041; IPR008930; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 CPAMD8 KIAA1283 Homo sapiens (Human) TR35408_c8_g4_i1 Q61838 A2M_MOUSE 1.00E-48 GO:0007566; GO:0004866; GO:0005576; GO:0005615; GO:0004867 embryo implantation; endopeptidase inhibitor activity; extracellular region; extracellular space; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; Alpha-2-macroglobulin (Alpha-2-M) (Pregnancy zone protein) [Cleaved into: Alpha-2-macroglobulin 165 kDa subunit; Alpha-2-macroglobulin 35 kDa subunit] A2m Pzp Mus musculus (Mouse) TR35408_c8_g5_i1 P01031 CO5_HUMAN 2.00E-15 GO:0007186; GO:0000187; GO:0006874; GO:0008009; GO:0006935; GO:0006956; GO:0006957; GO:0006958; GO:0019835; GO:0004866; GO:0005615; GO:0042593; GO:0001701; GO:0006954; GO:0045087; GO:0002523; GO:0005579; GO:0033602; GO:0010951; GO:0010760; GO:0010700; GO:0045766; GO:0090197; GO:0050921; GO:0010575; GO:0030449 Q91132 "G-protein coupled receptor signaling pathway; activation of MAPK activity; cellular calcium ion homeostasis; chemokine activity; chemotaxis; complement activation; complement activation, alternative pathway; complement activation, classical pathway; cytolysis; endopeptidase inhibitor activity; extracellular space; glucose homeostasis; in utero embryonic development; inflammatory response; innate immune response; leukocyte migration involved in inflammatory response; membrane attack complex; negative regulation of dopamine secretion; negative regulation of endopeptidase activity; negative regulation of macrophage chemotaxis; negative regulation of norepinephrine secretion; positive regulation of angiogenesis; positive regulation of chemokine secretion; positive regulation of chemotaxis; positive regulation vascular endothelial growth factor production; regulation of complement activation" IPR009048; IPR011626; IPR002890; IPR011625; IPR000020; IPR018081; IPR001840; IPR001599; IPR001134; IPR018933; IPR008930; IPR008993; Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain] C5 CPAMD4 Homo sapiens (Human) TR35410_c0_g1_i1 Q9BUP3 HTAI2_HUMAN 5.00E-70 GO:0001525; GO:0006915; GO:0030154; GO:0005737; GO:0019048; GO:0043066; GO:0005635; GO:0051170; GO:0016491; GO:0045765; GO:0006357; GO:0003713 angiogenesis; apoptotic process; cell differentiation; cytoplasm; modulation by virus of host morphology or physiology; negative regulation of apoptotic process; nuclear envelope; nuclear import; oxidoreductase activity; regulation of angiogenesis; regulation of transcription from RNA polymerase II promoter; transcription coactivator activity IPR016040 Oxidoreductase HTATIP2 (EC 1.1.1.-) (30 kDa HIV-1 TAT-interacting protein) (HIV-1 TAT-interactive protein 2) HTATIP2 CC3 TIP30 Homo sapiens (Human) TR35411_c0_g1_i1 Q8HYW0 FA13A_BOVIN 1.00E-31 Protein FAM13A (Protein Precm1) FAM13A FAM13A1 PRECM1 Bos taurus (Bovine) TR35412_c0_g1_i1 Q9VAQ5 DIM1_DROME 1.00E-153 GO:0052909; GO:0003723; GO:0022008; GO:0005730; GO:0000179; GO:0031167 "18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity; RNA binding; neurogenesis; nucleolus; rRNA (adenine-N6,N6-)-dimethyltransferase activity; rRNA methylation" IPR025814; IPR020596; IPR001737; IPR020598; IPR011530; "Probable dimethyladenosine transferase (EC 2.1.1.183) (Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase) (Probable 18S rRNA dimethylase) (Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase)" CG11837 Drosophila melanogaster (Fruit fly) TR35413_c0_g1_i2 Q9R044 NPHN_RAT 3.00E-11 GO:0007155; GO:0003094; GO:0016021; GO:0045121; GO:0007517; GO:0005886; GO:0043234; GO:0036057 P97710 cell adhesion; glomerular filtration; integral to membrane; membrane raft; muscle organ development; plasma membrane; protein complex; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Rattus norvegicus (Rat) TR35413_c0_g1_i3 Q9R044 NPHN_RAT 7.00E-11 GO:0007155; GO:0003094; GO:0016021; GO:0045121; GO:0007517; GO:0005886; GO:0043234; GO:0036057 P97710 cell adhesion; glomerular filtration; integral to membrane; membrane raft; muscle organ development; plasma membrane; protein complex; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Rattus norvegicus (Rat) TR35414_c4_g2_i2 D4PHA7 WSCD2_MOUSE 4.00E-06 GO:0016021 integral to membrane IPR027417; IPR002889; IPR013994; WSC domain-containing protein 2 Wscd2 Kiaa0789 Mus musculus (Mouse) TR35414_c4_g2_i8 Q5QQ53 XYLT_DROPS 3.00E-06 GO:0042732; GO:0000139; GO:0008375; GO:0030206; GO:0050650; GO:0005789; GO:0015012; GO:0016021; GO:0030158 D-xylose metabolic process; Golgi membrane; acetylglucosaminyltransferase activity; chondroitin sulfate biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process; endoplasmic reticulum membrane; heparan sulfate proteoglycan biosynthetic process; integral to membrane; protein xylosyltransferase activity IPR003406; IPR002889; IPR024448; Glycan metabolism; chondroitin sulfate biosynthesis. Glycan metabolism; heparan sulfate biosynthesis. Xylosyltransferase oxt (EC 2.4.2.26) (Peptide O-xylosyltransferase) oxt xt GA16815 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR35414_c4_g2_i9 Q8NCW0 KREM2_HUMAN 2.00E-08 GO:0016055; GO:0016021 Wnt receptor signaling pathway; integral to membrane IPR000859; IPR017076; IPR000001; IPR013806; IPR018056; IPR002889; Kremen protein 2 (Dickkopf receptor 2) (Kringle domain-containing transmembrane protein 2) (Kringle-containing protein marking the eye and the nose) KREMEN2 KRM2 Homo sapiens (Human) TR35415_c3_g3_i1 Q9R1S8 CAN7_MOUSE 0 GO:0004198; GO:0005634; GO:0097264 calcium-dependent cysteine-type endopeptidase activity; nucleus; self proteolysis IPR022684; IPR022682; IPR022683; IPR007330; IPR001300; Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH) Capn7 Palbh Mus musculus (Mouse) TR35415_c3_g3_i3 Q9R1S8 CAN7_MOUSE 0 GO:0004198; GO:0005634; GO:0097264 calcium-dependent cysteine-type endopeptidase activity; nucleus; self proteolysis IPR022684; IPR022682; IPR022683; IPR007330; IPR001300; Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH) Capn7 Palbh Mus musculus (Mouse) TR35415_c3_g3_i4 Q9GLG7 CAN3_MACFA 2.00E-13 GO:0030315; GO:0030018; GO:0005509; GO:0004198; GO:0071277; GO:0071472; GO:0005829; GO:0055103; GO:0043066; GO:0033234; GO:0045892; GO:0005634; GO:0051092; GO:0045862; GO:0051281; GO:0014718; GO:0045893; GO:0043234; GO:0006461; GO:0032947; GO:0072657; GO:0043122; GO:0014850; GO:0045214; GO:0097264; GO:0031402; GO:0008307; GO:0031432 "T-tubule; Z disc; calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cellular response to calcium ion; cellular response to salt stress; cytosol; ligase regulator activity; negative regulation of apoptotic process; negative regulation of protein sumoylation; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of proteolysis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of satellite cell activation involved in skeletal muscle regeneration; positive regulation of transcription, DNA-dependent; protein complex; protein complex assembly; protein complex scaffold; protein localization to membrane; regulation of I-kappaB kinase/NF-kappaB cascade; response to muscle activity; sarcomere organization; self proteolysis; sodium ion binding; structural constituent of muscle; titin binding" IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Cn94) (Muscle-specific calcium-activated neutral protease 3) CAPN3 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR35415_c3_g3_i5 Q9HFC8 PALB_YARLI 1.00E-39 GO:0004198; GO:0005622; GO:0006508 calcium-dependent cysteine-type endopeptidase activity; intracellular; proteolysis IPR022682; IPR022683; IPR001300; Calpain-like protease palB/RIM13 (EC 3.4.22.-) (Cysteine protease RIM13) RIM13 YALI0D14740g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR35416_c0_g1_i1 P69341 PARN_BOVIN 8.00E-171 GO:0003723; GO:0005737; GO:0046872; GO:0000184; GO:0090305; GO:0000166; GO:0005634; GO:0004535 "RNA binding; cytoplasm; metal ion binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleic acid phosphodiester bond hydrolysis; nucleotide binding; nucleus; poly(A)-specific ribonuclease activity" IPR012677; IPR014789; IPR001374; IPR006941; IPR012337; Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) PARN DAN Bos taurus (Bovine) TR35417_c1_g1_i1 P14262 PLC_BACCE 2.00E-26 GO:0005576; GO:0016042; GO:0004436; GO:0008081 extracellular region; lipid catabolic process; phosphatidylinositol diacylglycerol-lyase activity; phosphoric diester hydrolase activity IPR017946; IPR000909; 1-phosphatidylinositol phosphodiesterase (EC 4.6.1.13) (Phosphatidylinositol diacylglycerol-lyase) (Phosphatidylinositol-specific phospholipase C) (PI-PLC) Bacillus cereus TR35417_c1_g1_i2 P34024 PLC_LISMO 5.00E-36 GO:0005737; GO:0005576; GO:0016042; GO:0009405; GO:0004436; GO:0008081 cytoplasm; extracellular region; lipid catabolic process; pathogenesis; phosphatidylinositol diacylglycerol-lyase activity; phosphoric diester hydrolase activity IPR017946; IPR000909; 1-phosphatidylinositol phosphodiesterase (EC 4.6.1.13) (Phosphatidylinositol diacylglycerol-lyase) (Phosphatidylinositol-specific phospholipase C) (PI-PLC) plcA pic lmo0201 Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) TR35418_c4_g2_i1 Q8CII2 CD123_MOUSE 2.00E-96 GO:0007049; GO:0051301; GO:0005737 cell cycle; cell division; cytoplasm IPR016525; IPR009772; Cell division cycle protein 123 homolog Cdc123 Mus musculus (Mouse) TR35419_c2_g1_i2 Q8BWR4 UBP40_MOUSE 7.00E-33 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.4.19.12) (Deubiquitinating enzyme 40) (Ubiquitin thioesterase 40) (Ubiquitin-specific-processing protease 40) Usp40 Mus musculus (Mouse) TR35419_c3_g1_i1 Q9NVE5 UBP40_HUMAN 7.00E-23 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.4.19.12) (Deubiquitinating enzyme 40) (Ubiquitin thioesterase 40) (Ubiquitin-specific-processing protease 40) USP40 Homo sapiens (Human) TR3542_c0_g1_i1 Q7TT15 GLTL3_MOUSE 3.00E-41 GO:0000139; GO:0016021; GO:0004653; GO:0006486 Golgi membrane; integral to membrane; polypeptide N-acetylgalactosaminyltransferase activity; protein glycosylation IPR001173; IPR000772; Protein modification; protein glycosylation. Putative polypeptide N-acetylgalactosaminyltransferase-like protein 3 (EC 2.4.1.41) (Polypeptide GalNAc transferase-like protein 3) (GalNAc-T-like protein 3) (pp-GaNTase-like protein 3) (Protein-UDP acetylgalactosaminyltransferase-like protein 3) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 3) (Williams-Beuren syndrome chromosomal region 17 protein homolog) Wbscr17 Galntl3 Mus musculus (Mouse) TR3542_c0_g1_i2 Q6P6V1 GLT11_RAT 1.00E-39 GO:0000139; GO:0016021; GO:0004653; GO:0006486 Golgi membrane; integral to membrane; polypeptide N-acetylgalactosaminyltransferase activity; protein glycosylation IPR027791; IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11) Galnt11 Rattus norvegicus (Rat) TR35420_c1_g1_i2 P18503 CAS4_EPHMU 2.00E-07 GO:0005581 collagen IPR008160; Short-chain collagen C4 (Fragment) Ephydatia muelleri (Mueller's freshwater sponge) TR35422_c0_g1_i1 Q9BQ90 KLDC3_HUMAN 2.00E-151 GO:0006987; GO:0044267; GO:0003682; GO:0005829; GO:0000790; GO:0007131 activation of signaling protein activity involved in unfolded protein response; cellular protein metabolic process; chromatin binding; cytosol; nuclear chromatin; reciprocal meiotic recombination IPR015915; IPR011498; Kelch domain-containing protein 3 (Protein Peas) (Testis intracellular mediator protein) KLHDC3 PEAS Homo sapiens (Human) TR35422_c0_g1_i2 Q61191 HCFC1_MOUSE 1.00E-25 GO:0005671; GO:0071339; GO:0070688; GO:0001205; GO:0070461; GO:0048188; GO:0007049; GO:0003682; GO:0005737; GO:0043984; GO:0043981; GO:0043982; GO:0046972; GO:0043995; GO:0043996; GO:0000123; GO:0005739; GO:0000122; GO:0043025; GO:0050821; GO:0043254; GO:0019046; GO:0003713 Ada2/Gcn5/Ada3 transcription activator complex; MLL1 complex; MLL5-L complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; SAGA-type complex; Set1C/COMPASS complex; cell cycle; chromatin binding; cytoplasm; histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase activity (H4-K16 specific); histone acetyltransferase activity (H4-K5 specific); histone acetyltransferase activity (H4-K8 specific); histone acetyltransferase complex; mitochondrion; negative regulation of transcription from RNA polymerase II promoter; neuronal cell body; protein stabilization; regulation of protein complex assembly; release from viral latency; transcription coactivator activity IPR003961; IPR013783; IPR015915; IPR006652; Host cell factor 1 (HCF) (HCF-1) (C1 factor) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] Hcfc1 Mus musculus (Mouse) TR35422_c0_g1_i4 Q5R8W1 KLDC4_PONAB 1.00E-05 IPR015915; IPR011498; Kelch domain-containing protein 4 KLHDC4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35422_c0_g1_i5 Q9BQ90 KLDC3_HUMAN 1.00E-151 GO:0006987; GO:0044267; GO:0003682; GO:0005829; GO:0000790; GO:0007131 activation of signaling protein activity involved in unfolded protein response; cellular protein metabolic process; chromatin binding; cytosol; nuclear chromatin; reciprocal meiotic recombination IPR015915; IPR011498; Kelch domain-containing protein 3 (Protein Peas) (Testis intracellular mediator protein) KLHDC3 PEAS Homo sapiens (Human) TR35422_c0_g1_i6 Q61191 HCFC1_MOUSE 1.00E-25 GO:0005671; GO:0071339; GO:0070688; GO:0001205; GO:0070461; GO:0048188; GO:0007049; GO:0003682; GO:0005737; GO:0043984; GO:0043981; GO:0043982; GO:0046972; GO:0043995; GO:0043996; GO:0000123; GO:0005739; GO:0000122; GO:0043025; GO:0050821; GO:0043254; GO:0019046; GO:0003713 Ada2/Gcn5/Ada3 transcription activator complex; MLL1 complex; MLL5-L complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; SAGA-type complex; Set1C/COMPASS complex; cell cycle; chromatin binding; cytoplasm; histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase activity (H4-K16 specific); histone acetyltransferase activity (H4-K5 specific); histone acetyltransferase activity (H4-K8 specific); histone acetyltransferase complex; mitochondrion; negative regulation of transcription from RNA polymerase II promoter; neuronal cell body; protein stabilization; regulation of protein complex assembly; release from viral latency; transcription coactivator activity IPR003961; IPR013783; IPR015915; IPR006652; Host cell factor 1 (HCF) (HCF-1) (C1 factor) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] Hcfc1 Mus musculus (Mouse) TR35422_c0_g1_i7 Q9BQ90 KLDC3_HUMAN 1.00E-153 GO:0006987; GO:0044267; GO:0003682; GO:0005829; GO:0000790; GO:0007131 activation of signaling protein activity involved in unfolded protein response; cellular protein metabolic process; chromatin binding; cytosol; nuclear chromatin; reciprocal meiotic recombination IPR015915; IPR011498; Kelch domain-containing protein 3 (Protein Peas) (Testis intracellular mediator protein) KLHDC3 PEAS Homo sapiens (Human) TR35423_c1_g1_i1 Q9WTY1 PDCD7_MOUSE 2.00E-24 GO:0005689; GO:0006915; GO:0070234; GO:2001235; GO:0051384 U12-type spliceosomal complex; apoptotic process; positive regulation of T cell apoptotic process; positive regulation of apoptotic signaling pathway; response to glucocorticoid stimulus Programmed cell death protein 7 (ES18) Pdcd7 Mus musculus (Mouse) TR35424_c4_g1_i1 Q7T384 SC5AC_DANRE 9.00E-106 GO:0016021; GO:0015355; GO:0006814; GO:0015293 integral to membrane; secondary active monocarboxylate transmembrane transporter activity; sodium ion transport; symporter activity IPR001734; IPR019900; Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (zSMCTn) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12) (zSLC5A12) slc5a12 smctn Danio rerio (Zebrafish) (Brachydanio rerio) TR35424_c5_g1_i1 Q5G267 NETR_MACMU 9.00E-34 GO:0030424; GO:0006887; GO:0005576; GO:0005886; GO:0006508; GO:0005044; GO:0004252 axon; exocytosis; extracellular region; plasma membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR001190; IPR017448; IPR009003; Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Macaca mulatta (Rhesus macaque) TR35424_c5_g1_i3 P58215 LOXL3_HUMAN 4.00E-23 GO:0005507; GO:0001837; GO:0005576; GO:0005615; GO:0016020; GO:0045892; GO:0005634; GO:0004720; GO:0005044 "copper ion binding; epithelial to mesenchymal transition; extracellular region; extracellular space; membrane; negative regulation of transcription, DNA-dependent; nucleus; protein-lysine 6-oxidase activity; scavenger receptor activity" IPR001695; IPR019828; IPR001190; IPR017448; Lysyl oxidase homolog 3 (EC 1.4.3.-) (Lysyl oxidase-like protein 3) LOXL3 LOXL Homo sapiens (Human) TR35424_c5_g1_i4 Q9WUB9 MARCO_MESAU 2.00E-34 GO:0005581; GO:0045087; GO:0016021; GO:0005044 collagen; innate immune response; integral to membrane; scavenger receptor activity IPR008160; IPR001190; IPR017448; Macrophage receptor MARCO (Macrophage receptor with collagenous structure) MARCO Mesocricetus auratus (Golden hamster) TR35426_c0_g1_i1 Q796Q6 YISV_BACSU 2.00E-29 GO:0003677; GO:0030170; GO:0003700; GO:0008483; GO:0006351 "DNA binding; pyridoxal phosphate binding; sequence-specific DNA binding transcription factor activity; transaminase activity; transcription, DNA-dependent" IPR004839; IPR015424; IPR015421; IPR015422; IPR000524; IPR011991; Uncharacterized HTH-type transcriptional regulator YisV yisV BSU10880 Bacillus subtilis (strain 168) TR35426_c0_g1_i2 Q5E9N4 AADAT_BOVIN 5.00E-125 GO:0047536; GO:0006103; GO:0033512; GO:0009058; GO:0006536; GO:0016212; GO:0005739; GO:0030170 2-aminoadipate transaminase activity; 2-oxoglutarate metabolic process; L-lysine catabolic process to acetyl-CoA via saccharopine; biosynthetic process; glutamate metabolic process; kynurenine-oxoglutarate transaminase activity; mitochondrion; pyridoxal phosphate binding IPR004839; IPR015424; IPR015421; IPR015422; Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 4/6. "Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (KAT/AadAT) (2-aminoadipate aminotransferase) (2-aminoadipate transaminase) (EC 2.6.1.39) (Alpha-aminoadipate aminotransferase) (AadAT) (Kynurenine aminotransferase II) (Kynurenine--oxoglutarate aminotransferase II) (Kynurenine--oxoglutarate transaminase 2) (EC 2.6.1.7) (Kynurenine--oxoglutarate transaminase II)" AADAT Bos taurus (Bovine) TR35427_c1_g1_i4 Q3T0H0 LCMT1_BOVIN 1.00E-100 GO:0031333; GO:0003880; GO:0042981; GO:0090266 negative regulation of protein complex assembly; protein C-terminal carboxyl O-methyltransferase activity; regulation of apoptotic process; regulation of mitotic cell cycle spindle assembly checkpoint IPR007213; IPR016651; Leucine carboxyl methyltransferase 1 (EC 2.1.1.233) ([Phosphatase 2A protein]-leucine-carboxy methyltransferase 1) LCMT1 Bos taurus (Bovine) TR35429_c0_g2_i2 P55859 PNPH_BOVIN 1.00E-94 GO:0005737; GO:0005856; GO:0009116; GO:0004731 cytoplasm; cytoskeleton; nucleoside metabolic process; purine-nucleoside phosphorylase activity IPR000845; IPR001369; IPR011270; IPR011268; IPR018099; Purine metabolism; purine nucleoside salvage. Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) PNP NP Bos taurus (Bovine) TR35432_c0_g1_i2 O43148 MCES_HUMAN 6.00E-124 GO:0003723; GO:0004482; GO:0005845; GO:0005730; GO:0005654; GO:0006366; GO:0016032 RNA binding; mRNA (guanine-N7-)-methyltransferase activity; mRNA cap binding complex; nucleolus; nucleoplasm; transcription from RNA polymerase II promoter; viral process IPR016899; IPR004971; mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7)-)-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) RNMT KIAA0398 Homo sapiens (Human) TR35433_c0_g1_i1 O08852 PKD1_MOUSE 2.00E-10 GO:0007259; GO:0016323; GO:0048754; GO:0005262; GO:0030246; GO:0001502; GO:0007050; GO:0005737; GO:0042994; GO:0050982; GO:0048565; GO:0001892; GO:0048806; GO:0007507; GO:0016021; GO:0001822; GO:0001889; GO:0060428; GO:0072177; GO:0072218; GO:0072205; GO:0072287; GO:0072237; GO:0031512; GO:0021915; GO:0007218; GO:0006807; GO:0005634; GO:0018105; GO:0060674; GO:0005886; GO:0002133; GO:0031659; GO:0032092; GO:0045944; GO:0006611; GO:0060236; GO:0043588; GO:0021510 JAK-STAT cascade; basolateral plasma membrane; branching morphogenesis of an epithelial tube; calcium channel activity; carbohydrate binding; cartilage condensation; cell cycle arrest; cytoplasm; cytoplasmic sequestering of transcription factor; detection of mechanical stimulus; digestive tract development; embryonic placenta development; genitalia development; heart development; integral to membrane; kidney development; liver development; lung epithelium development; mesonephric duct development; metanephric ascending thin limb development; metanephric collecting duct development; metanephric distal tubule morphogenesis; metanephric proximal tubule development; motile primary cilium; neural tube development; neuropeptide signaling pathway; nitrogen compound metabolic process; nucleus; peptidyl-serine phosphorylation; placenta blood vessel development; plasma membrane; polycystin complex; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of protein binding; positive regulation of transcription from RNA polymerase II promoter; protein export from nucleus; regulation of mitotic spindle organization; skin development; spinal cord development IPR001304; IPR016186; IPR016187; IPR000483; IPR000203; IPR001611; IPR003591; IPR008976; IPR000372; IPR022409; IPR002859; IPR013122; IPR000434; IPR000601; IPR001024; IPR006228; IPR014010; IPR002889; IPR013994; Polycystin-1 (Autosomal dominant polycystic kidney disease 1 protein homolog) Pkd1 Mus musculus (Mouse) TR35433_c5_g1_i1 O16025 AOSL_PLEHO 2.00E-40 GO:0047677; GO:0019369; GO:0004096; GO:0005737; GO:0020037; GO:0047987; GO:0005506; GO:0016020; GO:0031408 arachidonate 8(R)-lipoxygenase activity; arachidonic acid metabolic process; catalase activity; cytoplasm; heme binding; hydroperoxide dehydratase activity; iron ion binding; membrane; oxylipin biosynthetic process IPR020835; IPR011614; IPR008976; IPR000907; IPR013819; IPR020834; IPR020833; IPR001885; IPR001024; Lipid metabolism; arachidonate metabolism. Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (EC 4.2.1.92) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)] Plexaura homomalla (Black sea rod) TR35433_c5_g1_i3 P09917 LOX5_HUMAN 2.00E-63 GO:0004051; GO:0019369; GO:0005829; GO:0005506; GO:0019370; GO:0002540; GO:2001300; GO:0019372; GO:0005641; GO:0016363; GO:0031965 Q14019 arachidonate 5-lipoxygenase activity; arachidonic acid metabolic process; cytosol; iron ion binding; leukotriene biosynthetic process; leukotriene production involved in inflammatory response; lipoxin metabolic process; lipoxygenase pathway; nuclear envelope lumen; nuclear matrix; nuclear membrane IPR008976; IPR000907; IPR013819; IPR020834; IPR020833; IPR001885; IPR001024; Lipid metabolism; leukotriene A4 biosynthesis. Arachidonate 5-lipoxygenase (5-LO) (5-lipoxygenase) (EC 1.13.11.34) ALOX5 LOG5 Homo sapiens (Human) TR35433_c5_g1_i5 Q8YK97 LILIP_NOSS1 2.00E-06 GO:0004096; GO:0020037; GO:0046872; GO:0016702; GO:0031408 "catalase activity; heme binding; metal ion binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; oxylipin biosynthetic process" IPR020835; IPR011614; IPR000907; IPR013819; Lipid metabolism; oxylipin biosynthesis. Linolenate 9R-lipoxygenase (EC 1.13.11.61) (NspLOX) all8020 Nostoc sp. (strain PCC 7120 / UTEX 2576) TR35433_c5_g1_i7 Q8IVV2 LOXH1_HUMAN 1.00E-06 GO:0005262; GO:0050982; GO:0016020; GO:0007605; GO:0032420 calcium channel activity; detection of mechanical stimulus; membrane; sensory perception of sound; stereocilium IPR008976; IPR001024; Lipoxygenase homology domain-containing protein 1 LOXHD1 Homo sapiens (Human) TR35433_c5_g1_i9 O16025 AOSL_PLEHO 6.00E-64 GO:0047677; GO:0019369; GO:0004096; GO:0005737; GO:0020037; GO:0047987; GO:0005506; GO:0016020; GO:0031408 arachidonate 8(R)-lipoxygenase activity; arachidonic acid metabolic process; catalase activity; cytoplasm; heme binding; hydroperoxide dehydratase activity; iron ion binding; membrane; oxylipin biosynthetic process IPR020835; IPR011614; IPR008976; IPR000907; IPR013819; IPR020834; IPR020833; IPR001885; IPR001024; Lipid metabolism; arachidonate metabolism. Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (EC 4.2.1.92) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)] Plexaura homomalla (Black sea rod) TR35437_c6_g2_i3 Q3ZBM7 TRPT1_BOVIN 5.00E-08 GO:0000215; GO:0006388 "tRNA 2'-phosphotransferase activity; tRNA splicing, via endonucleolytic cleavage and ligation" IPR002745; tRNA 2'-phosphotransferase 1 (EC 2.7.1.160) TRPT1 Bos taurus (Bovine) TR35438_c0_g1_i3 Q9UHC7 MKRN1_HUMAN 3.00E-111 GO:0003682; GO:0016874; GO:0016567; GO:0008270 P38936; P04637 chromatin binding; ligase activity; protein ubiquitination; zinc ion binding IPR026290; IPR018957; IPR000571; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase makorin-1 (EC 6.3.2.-) (RING finger protein 61) MKRN1 RNF61 Homo sapiens (Human) TR35438_c0_g1_i8 Q9TT91 MKRN1_MACEU 3.00E-110 GO:0016874; GO:0016567; GO:0008270 ligase activity; protein ubiquitination; zinc ion binding IPR026290; IPR018957; IPR000571; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase makorin-1 (EC 6.3.2.-) MKRN1 Macropus eugenii (Tammar wallaby) TR35438_c0_g1_i9 Q9UHC7 MKRN1_HUMAN 3.00E-111 GO:0003682; GO:0016874; GO:0016567; GO:0008270 P38936; P04637 chromatin binding; ligase activity; protein ubiquitination; zinc ion binding IPR026290; IPR018957; IPR000571; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase makorin-1 (EC 6.3.2.-) (RING finger protein 61) MKRN1 RNF61 Homo sapiens (Human) TR35439_c0_g2_i1 Q9Y6R9 CCD61_HUMAN 5.00E-80 GO:0005813 centrosome Coiled-coil domain-containing protein 61 CCDC61 Homo sapiens (Human) TR35440_c2_g3_i3 Q4L751 Y1215_STAHJ 3.00E-12 GO:0005737; GO:0006950 cytoplasm; response to stress IPR014729; IPR006015; IPR006016; Putative universal stress protein SH1215 SH1215 Staphylococcus haemolyticus (strain JCSC1435) TR35445_c0_g2_i1 Q6DK93 CNFN_XENTR 8.00E-11 IPR006461; Cornifelin homolog cnfn TNeu057a17.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35445_c0_g2_i2 Q08EJ0 PL8L1_MOUSE 9.00E-09 IPR006461; PLAC8-like protein 1 Plac8l1 Mus musculus (Mouse) TR35446_c0_g1_i1 Q95283 COX41_PIG 9.00E-08 GO:0004129; GO:0005743 cytochrome-c oxidase activity; mitochondrial inner membrane IPR013288; IPR004203; "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) (Fragment)" COX4I1 COX4 Sus scrofa (Pig) TR35446_c0_g1_i2 O46578 COX41_GORGO 2.00E-21 GO:0004129; GO:0005743; GO:0005634 cytochrome-c oxidase activity; mitochondrial inner membrane; nucleus IPR013288; IPR004203; "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) (Fragment)" COX4I1 COX4 Gorilla gorilla gorilla (Lowland gorilla) TR35450_c0_g1_i1 Q924H0 NPFF2_MOUSE 3.00E-10 GO:0015629; GO:0005887; GO:0008188; GO:0007218; GO:0043408; GO:0045761; GO:2000479 actin cytoskeleton; integral to plasma membrane; neuropeptide receptor activity; neuropeptide signaling pathway; regulation of MAPK cascade; regulation of adenylate cyclase activity; regulation of cAMP-dependent protein kinase activity IPR000276; IPR017452; IPR005395; IPR005397; Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide NPFF receptor) Npffr2 Gpr74 Npff2 Mus musculus (Mouse) TR35450_c0_g1_i2 P25931 NPYR_DROME 9.00E-11 GO:0016021; GO:0004983; GO:0008188; GO:0005886 integral to membrane; neuropeptide Y receptor activity; neuropeptide receptor activity; plasma membrane IPR000276; IPR017452; IPR000611; Neuropeptide Y receptor (NPY-R) (PR4 receptor) NepYr CG5811 Drosophila melanogaster (Fruit fly) TR35451_c0_g1_i1 O94972 TRI37_HUMAN 6.00E-94 GO:0016235; GO:0070842; GO:0005829; GO:0032088; GO:0046600; GO:0048471; GO:0005777; GO:0051865; GO:0042803; GO:0004842; GO:0008270 O43663 aggresome; aggresome assembly; cytosol; negative regulation of NF-kappaB transcription factor activity; negative regulation of centriole replication; perinuclear region of cytoplasm; peroxisome; protein autoubiquitination; protein homodimerization activity; ubiquitin-protein ligase activity; zinc ion binding IPR003649; IPR002083; IPR008974; IPR000315; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM37 (EC 6.3.2.-) (Mulibrey nanism protein) (Tripartite motif-containing protein 37) TRIM37 KIAA0898 MUL POB1 Homo sapiens (Human) TR35451_c1_g4_i1 Q6PCX9 TRI37_MOUSE 3.00E-42 GO:0016235; GO:0070842; GO:0005737; GO:0005829; GO:0032088; GO:0046600; GO:0048471; GO:0005777; GO:0051865; GO:0004842; GO:0008270 aggresome; aggresome assembly; cytoplasm; cytosol; negative regulation of NF-kappaB transcription factor activity; negative regulation of centriole replication; perinuclear region of cytoplasm; peroxisome; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003649; IPR002083; IPR008974; IPR000315; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM37 (EC 6.3.2.-) (Tripartite motif-containing protein 37) Trim37 Kiaa0898 Mus musculus (Mouse) TR35454_c0_g1_i1 Q9T0K7 HIBC6_ARATH 8.00E-69 GO:0005829; GO:0016787; GO:0005739 cytosol; hydrolase activity; mitochondrion "3-hydroxyisobutyryl-CoA hydrolase-like protein 3, mitochondrial (EC 3.1.2.-)" At4g13360 T9E8.100 Arabidopsis thaliana (Mouse-ear cress) TR35454_c0_g1_i2 Q58EB4 HIBCH_DANRE 8.00E-166 GO:0003860; GO:0005739; GO:0006574 3-hydroxyisobutyryl-CoA hydrolase activity; mitochondrion; valine catabolic process Amino-acid degradation; L-valine degradation. "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (HIB-CoA hydrolase) (HIBYL-CoA-H)" hibch zgc:110824 Danio rerio (Zebrafish) (Brachydanio rerio) TR35455_c0_g1_i1 Q09990 LIN23_CAEEL 7.00E-32 GO:0007049; GO:0051301; GO:0005737; GO:0008285; GO:0048812; GO:0005634 cell cycle; cell division; cytoplasm; negative regulation of cell proliferation; neuron projection morphogenesis; nucleus IPR021977; IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein lin-23 (Abnormal cell lineage protein 23) lin-23 K10B2.1 Caenorhabditis elegans TR35455_c0_g1_i2 Q9VZF4 FBXW7_DROME 2.00E-48 GO:0042023; GO:0019005; GO:0007411; GO:0035147; GO:0071456; GO:0030332; GO:0008054; GO:1900038; GO:0060253; GO:0045926; GO:0005634; GO:0016567; GO:0007096; GO:0030162; GO:0060438 Q9W4S7 "DNA endoreduplication; SCF ubiquitin ligase complex; axon guidance; branch fusion, open tracheal system; cellular response to hypoxia; cyclin binding; cyclin catabolic process; negative regulation of cellular response to hypoxia; negative regulation of glial cell proliferation; negative regulation of growth; nucleus; protein ubiquitination; regulation of exit from mitosis; regulation of proteolysis; trachea development" IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (Protein archipelago) ago CG15010 Drosophila melanogaster (Fruit fly) TR35455_c0_g1_i3 Q6FJZ9 PRP46_CANGA 1.00E-12 GO:0008380; GO:0007049; GO:0005829; GO:0006397; GO:0005681 RNA splicing; cell cycle; cytosol; mRNA processing; spliceosomal complex IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Pre-mRNA-splicing factor PRP46 (Pre-mRNA-processing protein 46) PRP46 CAGL0M02277g Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) TR35455_c0_g1_i4 Q9VZF4 FBXW7_DROME 2.00E-48 GO:0042023; GO:0019005; GO:0007411; GO:0035147; GO:0071456; GO:0030332; GO:0008054; GO:1900038; GO:0060253; GO:0045926; GO:0005634; GO:0016567; GO:0007096; GO:0030162; GO:0060438 Q9W4S7 "DNA endoreduplication; SCF ubiquitin ligase complex; axon guidance; branch fusion, open tracheal system; cellular response to hypoxia; cyclin binding; cyclin catabolic process; negative regulation of cellular response to hypoxia; negative regulation of glial cell proliferation; negative regulation of growth; nucleus; protein ubiquitination; regulation of exit from mitosis; regulation of proteolysis; trachea development" IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (Protein archipelago) ago CG15010 Drosophila melanogaster (Fruit fly) TR35455_c0_g1_i5 P87053 POF1_SCHPO 1.00E-34 GO:0019005; GO:0071276; GO:0005634; GO:0042787; GO:0007346 Q9Y709 SCF ubiquitin ligase complex; cellular response to cadmium ion; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of mitotic cell cycle IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein pof1 (Skp1-binding protein 1) pof1 sbp1 SPAC57A10.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR35456_c0_g1_i1 Q8BY87 UBP47_MOUSE 0 GO:0019005; GO:0006284; GO:0034644; GO:0005737; GO:0035520; GO:0010972; GO:0043154; GO:1902230; GO:0045892; GO:0030307; GO:0042493; GO:0004221; GO:0006511; GO:0004843 "SCF ubiquitin ligase complex; base-excision repair; cellular response to UV; cytoplasm; monoubiquitinated protein deubiquitination; negative regulation of G2/M transition of mitotic cell cycle; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of transcription, DNA-dependent; positive regulation of cell growth; response to drug; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity" IPR018200; IPR001394; IPR027933; Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) Usp47 Mus musculus (Mouse) TR35456_c0_g1_i2 Q8BUM9 UBP43_MOUSE 1.00E-07 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) Usp43 Mus musculus (Mouse) TR35459_c0_g1_i1 Q0P5N6 ARL16_HUMAN 1.00E-41 GO:0005525; GO:0005622; GO:0007264 GTP binding; intracellular; small GTPase mediated signal transduction IPR027417; IPR024156; IPR006689; ADP-ribosylation factor-like protein 16 ARL16 Homo sapiens (Human) TR35461_c0_g3_i1 P36404 ARL2_HUMAN 9.00E-114 GO:0019003; GO:0005525; GO:0003924; GO:0005095; GO:0007049; GO:0005813; GO:0051297; GO:0016328; GO:0051457; GO:0005758; GO:0034260; GO:0005634; GO:0010811; GO:0031116; GO:0007264; GO:0070830; GO:0007021 O43924; Q13432 GDP binding; GTP binding; GTPase activity; GTPase inhibitor activity; cell cycle; centrosome; centrosome organization; lateral plasma membrane; maintenance of protein location in nucleus; mitochondrial intermembrane space; negative regulation of GTPase activity; nucleus; positive regulation of cell-substrate adhesion; positive regulation of microtubule polymerization; small GTPase mediated signal transduction; tight junction assembly; tubulin complex assembly IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 2 ARL2 Homo sapiens (Human) TR35461_c0_g3_i2 Q8BGR6 ARL15_MOUSE 2.00E-22 GO:0005525; GO:0005622; GO:0007264 GTP binding; intracellular; small GTPase mediated signal transduction IPR027417; IPR024156; IPR006689; ADP-ribosylation factor-like protein 15 (ADP-ribosylation factor-related protein 2) (ARF-related protein 2) Arl15 Arfrp2 Mus musculus (Mouse) TR35461_c0_g3_i4 Q96361 ARF1_BRARP 8.00E-54 GO:0005525; GO:0005794; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor 1 ARF1 Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica pekinensis) TR35462_c1_g1_i3 Q7ZU45 TTC25_DANRE 5.00E-144 IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 25 (TPR repeat protein 25) ttc25 Danio rerio (Zebrafish) (Brachydanio rerio) TR35462_c1_g1_i4 Q7ZU45 TTC25_DANRE 5.00E-144 IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 25 (TPR repeat protein 25) ttc25 Danio rerio (Zebrafish) (Brachydanio rerio) TR35467_c0_g1_i1 Q9D1D1 TSN11_MOUSE 1.00E-15 GO:0016021 integral to membrane IPR000301; IPR018499; IPR008952; Tetraspanin-11 (Tspan-11) Tspan11 Mus musculus (Mouse) TR35468_c1_g2_i1 Q95KC8 TIP_MACFA 1.00E-20 GO:0005576; GO:0016021; GO:0005886 extracellular region; integral to membrane; plasma membrane IPR024881; T-cell immunomodulatory protein (Protein TIP) (Integrin-alpha FG-GAP repeat-containing protein 1) (Fragment) ITFG1 TIP QmoA-10172 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR35468_c1_g3_i1 Q8TB96 TIP_HUMAN 6.00E-99 GO:0005576; GO:0016021 extracellular region; integral to membrane IPR024881; T-cell immunomodulatory protein (Protein TIP) (Integrin-alpha FG-GAP repeat-containing protein 1) ITFG1 TIP CDA08 Homo sapiens (Human) TR35469_c0_g1_i1 Q561P5 MCM5_XENTR 0 GO:0005524; GO:0006200; GO:0003677; GO:0003678; GO:0006270; GO:0006268; GO:0042555; GO:0007049; GO:0000785; GO:0005634; GO:0030174 ATP binding; ATP catabolic process; DNA binding; DNA helicase activity; DNA replication initiation; DNA unwinding involved in DNA replication; MCM complex; cell cycle; chromatin; nucleus; regulation of DNA-dependent DNA replication initiation IPR008048; IPR018525; IPR001208; IPR027925; IPR012340; IPR027417; DNA replication licensing factor mcm5 (EC 3.6.4.12) mcm5 TEgg011k14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35472_c0_g1_i1 Q04073 P3A2_STRPU 5.00E-110 GO:0003677; GO:0005634; GO:0006355; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019526; IPR019525; DNA-binding protein P3A2 Strongylocentrotus purpuratus (Purple sea urchin) TR35474_c7_g1_i1 Q9UKR8 TSN16_HUMAN 2.00E-07 GO:0016021 integral to membrane IPR000301; IPR018499; IPR008952; Tetraspanin-16 (Tspan-16) (Tetraspanin TM4-B) (Transmembrane 4 superfamily member 16) TSPAN16 TM4SF16 Homo sapiens (Human) TR35474_c8_g1_i1 Q9UKR8 TSN16_HUMAN 3.00E-09 GO:0016021 integral to membrane IPR000301; IPR018499; IPR008952; Tetraspanin-16 (Tspan-16) (Tetraspanin TM4-B) (Transmembrane 4 superfamily member 16) TSPAN16 TM4SF16 Homo sapiens (Human) TR35475_c0_g1_i1 O00909 ARF1_DICDI 1.00E-70 GO:0005525; GO:0005794; GO:0000281; GO:0048471; GO:0045335; GO:0015031; GO:0051489; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; mitotic cytokinesis; perinuclear region of cytoplasm; phagocytic vesicle; protein transport; regulation of filopodium assembly; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor 1 arfA arf1 DDB_G0289173 Dictyostelium discoideum (Slime mold) TR35475_c0_g1_i4 P34727 ARF_AJECA 8.00E-69 GO:0005525; GO:0005794; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor ARF Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum) TR35475_c0_g1_i5 Q5H913 AR13A_HUMAN 2.00E-14 GO:0005525; GO:0005622; GO:0007264 GTP binding; intracellular; small GTPase mediated signal transduction IPR027417; IPR024156; IPR006689; ADP-ribosylation factor-like protein 13A ARL13A Homo sapiens (Human) TR35475_c0_g2_i1 Q8IVW1 ARL17_HUMAN 2.00E-24 GO:0005525; GO:0005794; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR024156; IPR006689; ADP-ribosylation factor-like protein 17 (ADP-ribosylation factor 7 variant) ARL17A ARL17P1; ARL17B ARF1P2 ARL17A PRO2667 Homo sapiens (Human) TR35476_c1_g1_i1 Q27607 DPOG1_DROME 0 GO:0003677; GO:0003887; GO:0008340; GO:0007562; GO:0005760; GO:0006264 O02005 DNA binding; DNA-directed DNA polymerase activity; determination of adult lifespan; eclosion; gamma DNA polymerase complex; mitochondrial DNA replication IPR019760; IPR002297; IPR001098; IPR012337; "DNA polymerase subunit gamma-1, mitochondrial (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) (Protein tamas)" tam MtPolA Polg CG8987 Drosophila melanogaster (Fruit fly) TR35477_c1_g1_i1 Q9NYV6 RRN3_HUMAN 7.00E-86 GO:0008283; GO:0007028; GO:0048872; GO:0001701; GO:0043066; GO:0005730; GO:0007000; GO:0005654; GO:0045893; GO:2000142; GO:0042254; GO:0006361 "cell proliferation; cytoplasm organization; homeostasis of number of cells; in utero embryonic development; negative regulation of apoptotic process; nucleolus; nucleolus organization; nucleoplasm; positive regulation of transcription, DNA-dependent; regulation of DNA-dependent transcription, initiation; ribosome biogenesis; transcription initiation from RNA polymerase I promoter" IPR007991; RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA) RRN3 TIFIA Homo sapiens (Human) TR35477_c1_g1_i2 Q9NYV6 RRN3_HUMAN 6.00E-117 GO:0008283; GO:0007028; GO:0048872; GO:0001701; GO:0043066; GO:0005730; GO:0007000; GO:0005654; GO:0045893; GO:2000142; GO:0042254; GO:0006361 "cell proliferation; cytoplasm organization; homeostasis of number of cells; in utero embryonic development; negative regulation of apoptotic process; nucleolus; nucleolus organization; nucleoplasm; positive regulation of transcription, DNA-dependent; regulation of DNA-dependent transcription, initiation; ribosome biogenesis; transcription initiation from RNA polymerase I promoter" IPR007991; RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA) RRN3 TIFIA Homo sapiens (Human) TR35480_c2_g1_i1 Q9FWW9 GSXL2_ARATH 4.00E-26 GO:0004499; GO:0050661; GO:0050832; GO:0050660 "N,N-dimethylaniline monooxygenase activity; NADP binding; defense response to fungus; flavin adenine dinucleotide binding" IPR000960; IPR020946; Flavin-containing monooxygenase FMO GS-OX-like 2 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 2) At1g12200 T28K15.7 Arabidopsis thaliana (Mouse-ear cress) TR35481_c1_g2_i1 Q5RAV9 GUAD_PONAB 3.00E-77 GO:0006147; GO:0008892; GO:0008270 guanine catabolic process; guanine deaminase activity; zinc ion binding IPR006680; IPR014311; Purine metabolism; guanine degradation; xanthine from guanine: step 1/1. Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) GDA Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35481_c1_g2_i2 Q5RAV9 GUAD_PONAB 7.00E-146 GO:0006147; GO:0008892; GO:0008270 guanine catabolic process; guanine deaminase activity; zinc ion binding IPR006680; IPR014311; Purine metabolism; guanine degradation; xanthine from guanine: step 1/1. Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) GDA Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35485_c0_g1_i1 O61715 INX19_CAEEL 1.00E-53 GO:0019855; GO:0030154; GO:0035545; GO:0005921; GO:0055077; GO:0051390; GO:0016021; GO:0010496; GO:0006811; GO:2001258; GO:0032809; GO:0004860 calcium channel inhibitor activity; cell differentiation; determination of left/right asymmetry in nervous system; gap junction; gap junction hemi-channel activity; inactivation of MAPKKK activity; integral to membrane; intercellular transport; ion transport; negative regulation of cation channel activity; neuronal cell body membrane; protein kinase inhibitor activity IPR000990; Innexin-19 (Neuronal symmetry protein 5) (Protein opu-19) inx-19 nsy-5 opu-19 T16H5.1 Caenorhabditis elegans TR35485_c0_g1_i3 O01393 UNC9_CAEEL 2.00E-67 GO:0005921; GO:0055077; GO:0016021; GO:0034220; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transmembrane transport; plasma membrane IPR000990; Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans TR35486_c1_g1_i2 Q9D903 EBP2_MOUSE 2.00E-62 GO:0007059; GO:0005730; GO:0006364 chromosome segregation; nucleolus; rRNA processing IPR008610; Probable rRNA-processing protein EBP2 Ebna1bp2 Ebp2 Mus musculus (Mouse) TR35487_c0_g1_i1 Q8D357 DXS_WIGBR 1.00E-09 GO:0052865; GO:0008661; GO:0000287; GO:0016114; GO:0009228; GO:0030976 1-deoxy-D-xylulose 5-phosphate biosynthetic process; 1-deoxy-D-xylulose-5-phosphate synthase activity; magnesium ion binding; terpenoid biosynthetic process; thiamine biosynthetic process; thiamine pyrophosphate binding IPR005477; IPR009014; IPR005475; IPR005476; IPR005474; Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) dxs WIGBR1440 Wigglesworthia glossinidia brevipalpis TR35487_c0_g1_i2 Q5RE79 ODPB_PONAB 0 GO:0006086; GO:0006006; GO:0005759; GO:0004739; GO:0004738; GO:0045254; GO:0006099 acetyl-CoA biosynthetic process from pyruvate; glucose metabolic process; mitochondrial matrix; pyruvate dehydrogenase (acetyl-transferring) activity; pyruvate dehydrogenase activity; pyruvate dehydrogenase complex; tricarboxylic acid cycle IPR009014; IPR005475; IPR005476; "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)" PDHB Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35491_c1_g1_i2 B1H3B1 FUND1_XENTR 5.00E-28 GO:0031307; GO:0000422; GO:0001666 integral to mitochondrial outer membrane; mitochondrion degradation; response to hypoxia IPR007014; FUN14 domain-containing protein 1 fundc1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35493_c1_g1_i1 Q9QUM7 MSH5_MOUSE 2.00E-29 GO:0005524; GO:0008094; GO:0051026; GO:0007292; GO:0045143; GO:0006298; GO:0030983; GO:0005654; GO:0007131; GO:0000795 ATP binding; DNA-dependent ATPase activity; chiasma assembly; female gamete generation; homologous chromosome segregation; mismatch repair; mismatched DNA binding; nucleoplasm; reciprocal meiotic recombination; synaptonemal complex IPR000432; IPR007861; IPR007696; IPR027417; MutS protein homolog 5 Msh5 Mus musculus (Mouse) TR35493_c7_g2_i1 Q64270 EI2BA_RAT 2.00E-113 GO:0019003; GO:0005525; GO:0030234; GO:0005850; GO:0005851; GO:0005085; GO:0032057; GO:0014003; GO:0005886; GO:0009749; GO:0009408; GO:0043434; GO:0003743 GDP binding; GTP binding; enzyme regulator activity; eukaryotic translation initiation factor 2 complex; eukaryotic translation initiation factor 2B complex; guanyl-nucleotide exchange factor activity; negative regulation of translational initiation in response to stress; oligodendrocyte development; plasma membrane; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translation initiation factor activity IPR000649; Translation initiation factor eIF-2B subunit alpha (eIF-2B GDP-GTP exchange factor subunit alpha) Eif2b1 Eif2ba Rattus norvegicus (Rat) TR35493_c7_g2_i4 B9KA57 MTNA_THENN 2.00E-17 GO:0019284; GO:0019509; GO:0046523 L-methionine biosynthetic process from S-adenosylmethionine; L-methionine salvage from methylthioadenosine; S-methyl-5-thioribose-1-phosphate isomerase activity IPR000649; IPR005251; IPR011559; IPR027363; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. Methylthioribose-1-phosphate isomerase (M1Pi) (MTR-1-P isomerase) (EC 5.3.1.23) (S-methyl-5-thioribose-1-phosphate isomerase) mtnA CTN_1664 Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E) TR35493_c8_g1_i1 B8D298 MUTS2_HALOH 4.00E-06 GO:0005524; GO:0006200; GO:0016887; GO:0004519; GO:0006298; GO:0030983; GO:0090305 ATP binding; ATP catabolic process; ATPase activity; endonuclease activity; mismatch repair; mismatched DNA binding; nucleic acid phosphodiester bond hydrolysis IPR000432; IPR007696; IPR005747; IPR027417; IPR002625; Endonuclease MutS2 (EC 3.1.-.-) mutS2 Hore_05680 Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562) TR35493_c9_g1_i1 F4JEP5 MSH5_ARATH 2.00E-17 GO:0005524; GO:0008094; GO:0051026; GO:0003684; GO:0043073; GO:0045143; GO:0010777; GO:0032300; GO:0030983; GO:0000795 ATP binding; DNA-dependent ATPase activity; chiasma assembly; damaged DNA binding; germ cell nucleus; homologous chromosome segregation; meiotic mismatch repair involved in reciprocal meiotic recombination; mismatch repair complex; mismatched DNA binding; synaptonemal complex IPR000432; IPR007696; IPR027417; DNA mismatch repair protein MSH5 (AtMSH5) (MutS protein homolog 5) MSH5 At3g20475 MQC12.27 Arabidopsis thaliana (Mouse-ear cress) TR35494_c0_g1_i1 A8WVU7 CPG1_CAEBR 9.00E-06 GO:0008061; GO:0006030; GO:0009790; GO:0005576; GO:0000281 chitin binding; chitin metabolic process; embryo development; extracellular region; mitotic cytokinesis IPR002557; Chondroitin proteoglycan 1 (Cell junction protein 1) (Cytokinesis protein cej-1) cpg-1 CBG03957 Caenorhabditis briggsae TR35494_c0_g1_i2 P49013 FBP3_STRPU 5.00E-19 GO:0005509; GO:0005615 calcium ion binding; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) TR35494_c1_g1_i2 P16581 LYAM2_HUMAN 4.00E-10 GO:0030029; GO:0007202; GO:0007596; GO:0019722; GO:0005901; GO:0005905; GO:0030863; GO:0005615; GO:0007157; GO:0016021; GO:0002523; GO:0050901; GO:0070492; GO:0048471; GO:0043274; GO:0002687; GO:0002092; GO:0050727; GO:0070555; GO:0032496; GO:0034612; GO:0033691; GO:0004888 actin filament-based process; activation of phospholipase C activity; blood coagulation; calcium-mediated signaling; caveola; coated pit; cortical cytoskeleton; extracellular space; heterophilic cell-cell adhesion; integral to membrane; leukocyte migration involved in inflammatory response; leukocyte tethering or rolling; oligosaccharide binding; perinuclear region of cytoplasm; phospholipase binding; positive regulation of leukocyte migration; positive regulation of receptor internalization; regulation of inflammatory response; response to interleukin-1; response to lipopolysaccharide; response to tumor necrosis factor; sialic acid binding; transmembrane signaling receptor activity IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR002396; IPR000436; E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E) SELE ELAM1 Homo sapiens (Human) TR35497_c0_g2_i1 A3RLT6 RSSA_PINFU 6.00E-137 GO:0022627; GO:0000028; GO:0003735; GO:0006412 cytosolic small ribosomal subunit; ribosomal small subunit assembly; structural constituent of ribosome; translation IPR001865; IPR018130; IPR027498; IPR005707; IPR023591; 40S ribosomal protein SA Pinctada fucata (Pearl oyster) TR35499_c0_g1_i1 Q923Y7 TAAR4_RAT 9.00E-13 GO:0007610; GO:0016021; GO:0005886; GO:0001594 behavior; integral to membrane; plasma membrane; trace-amine receptor activity IPR000276; IPR017452; IPR009132; Trace amine-associated receptor 4 (TaR-4) (Trace amine receptor 4) (2-phenylethylamine receptor) (Trace amine receptor 2) (TaR-2) Taar4 Ta2 Tar2 Trar2 Rattus norvegicus (Rat) TR35505_c0_g1_i1 P69100 ERH_TAESO 8.00E-41 GO:0007049 cell cycle IPR000781; Enhancer of rudimentary homolog ERH Taenia solium (Pork tapeworm) TR35505_c0_g1_i5 Q93104 ERH_AEDAE 3.00E-50 GO:0007049 cell cycle IPR000781; Enhancer of rudimentary homolog Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR35505_c0_g1_i6 P69100 ERH_TAESO 1.00E-40 GO:0007049 cell cycle IPR000781; Enhancer of rudimentary homolog ERH Taenia solium (Pork tapeworm) TR35505_c0_g1_i7 Q93104 ERH_AEDAE 3.00E-50 GO:0007049 cell cycle IPR000781; Enhancer of rudimentary homolog Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR35506_c0_g1_i1 Q96PH1 NOX5_HUMAN 1.00E-134 GO:0050661; GO:0001525; GO:0006915; GO:0005509; GO:0050663; GO:0000910; GO:0005783; GO:0001935; GO:0050660; GO:0020037; GO:0015252; GO:0016021; GO:2000379; GO:0043012; GO:0010155; GO:0042554; GO:0016175 P62157 NADP binding; angiogenesis; apoptotic process; calcium ion binding; cytokine secretion; cytokinesis; endoplasmic reticulum; endothelial cell proliferation; flavin adenine dinucleotide binding; heme binding; hydrogen ion channel activity; integral to membrane; positive regulation of reactive oxygen species metabolic process; regulation of fusion of sperm to egg plasma membrane; regulation of proton transport; superoxide anion generation; superoxide-generating NADPH oxidase activity IPR011992; IPR018247; IPR002048; IPR013112; IPR017927; IPR013130; IPR013121; IPR017938; NADPH oxidase 5 (EC 1.6.3.-) NOX5 Homo sapiens (Human) TR35506_c0_g1_i2 Q54F44 NOXC_DICDI 3.00E-51 GO:0050661; GO:0043020; GO:0005509; GO:0050660; GO:0020037; GO:0030587; GO:0030435; GO:0042554; GO:0016175 NADP binding; NADPH oxidase complex; calcium ion binding; flavin adenine dinucleotide binding; heme binding; sorocarp development; sporulation resulting in formation of a cellular spore; superoxide anion generation; superoxide-generating NADPH oxidase activity IPR000778; IPR011992; IPR018247; IPR002048; IPR013112; IPR017927; IPR013130; IPR013121; IPR017938; Superoxide-generating NADPH oxidase heavy chain subunit C (EC 1.-.-.-) (NADPH oxidase C) (Superoxide-generating NADPH oxidase flavocytochrome C) noxC DDB_G0291117 Dictyostelium discoideum (Slime mold) TR35507_c0_g2_i1 Q25410 MIPR_LYMST 3.00E-108 GO:0005524; GO:0016021; GO:0046872; GO:0018108; GO:0004714; GO:0007169 ATP binding; integral to membrane; metal ion binding; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000494; IPR003961; IPR006211; IPR006212; IPR009030; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR002011; Putative molluscan insulin-related peptide(s) receptor (EC 2.7.10.1) [Cleaved into: Putative molluscan insulin-related peptide(s) receptor alpha chain; Putative molluscan insulin-related peptide(s) receptor beta chain] Lymnaea stagnalis (Great pond snail) TR35507_c0_g2_i2 O02466 ILPR_BRALA 2.00E-102 GO:0005524; GO:0016021; GO:0046872; GO:0018108; GO:0046777; GO:0004714; GO:0007169 ATP binding; integral to membrane; metal ion binding; peptidyl-tyrosine phosphorylation; protein autophosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000494; IPR003961; IPR006211; IPR006212; IPR009030; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR016246; IPR002011; Insulin-like peptide receptor (ILP receptor) (EC 2.7.10.1) [Cleaved into: Insulin-like peptide receptor alpha chain; Insulin-like peptide receptor beta chain] Branchiostoma lanceolatum (Common lancelet) (Amphioxus) TR35507_c0_g2_i5 Q25410 MIPR_LYMST 8.00E-110 GO:0005524; GO:0016021; GO:0046872; GO:0018108; GO:0004714; GO:0007169 ATP binding; integral to membrane; metal ion binding; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000494; IPR003961; IPR006211; IPR006212; IPR009030; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR002011; Putative molluscan insulin-related peptide(s) receptor (EC 2.7.10.1) [Cleaved into: Putative molluscan insulin-related peptide(s) receptor alpha chain; Putative molluscan insulin-related peptide(s) receptor beta chain] Lymnaea stagnalis (Great pond snail) TR35507_c1_g7_i1 O18473 ECR_HELVI 9.00E-09 GO:0004884; GO:0005634; GO:0043565; GO:0005496; GO:0008270 Q7SIF6 ecdysteroid hormone receptor activity; nucleus; sequence-specific DNA binding; steroid binding; zinc ion binding IPR003069; IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Ecdysone receptor (20-hydroxy-ecdysone receptor) (20E receptor) (EcRH) (Ecdysteroid receptor) (HvEcR) (Nuclear receptor subfamily 1 group H member 1) EcR NR1H1 Heliothis virescens (Tobacco budworm moth) TR35507_c1_g7_i2 Q60641 NR1H4_MOUSE 8.00E-26 GO:0000980; GO:0003705; GO:0001190; GO:0032052; GO:0008206; GO:0038181; GO:0071229; GO:1902122; GO:0048565; GO:0038185; GO:0004879; GO:0070858; GO:0000122; GO:0001080; GO:0005719; GO:0042277; GO:2001250; GO:0045944; GO:0006109; GO:0034255; GO:0009749; GO:0032496; GO:0046965; GO:0003707; GO:0004887; GO:0008270 RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; bile acid binding; bile acid metabolic process; bile acid receptor activity; cellular response to acid; chenodeoxycholic acid binding; digestive tract development; intracellular bile acid receptor signaling pathway; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; negative regulation of bile acid biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; nitrogen catabolite activation of transcription from RNA polymerase II promoter; nuclear euchromatin; peptide binding; positive regulation of ammonia assimilation cycle; positive regulation of transcription from RNA polymerase II promoter; regulation of carbohydrate metabolic process; regulation of urea metabolic process; response to glucose stimulus; response to lipopolysaccharide; retinoid X receptor binding; steroid hormone receptor activity; thyroid hormone receptor activity; zinc ion binding IPR008946; IPR000536; IPR001723; IPR001728; IPR001628; IPR013088; Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14) Nr1h4 Bar Fxr Rip14 Mus musculus (Mouse) TR35507_c1_g7_i3 Q24143 HR96_DROME 2.00E-35 GO:0000977; GO:0042632; GO:0004879; GO:0005634; GO:0070873; GO:0042594; GO:0003707; GO:0070328; GO:0008270 RNA polymerase II regulatory region sequence-specific DNA binding; cholesterol homeostasis; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleus; regulation of glycogen metabolic process; response to starvation; steroid hormone receptor activity; triglyceride homeostasis; zinc ion binding IPR008946; IPR000536; IPR001628; IPR013088; Nuclear hormone receptor HR96 (dHR96) (Nuclear receptor subfamily 1 group J member 1) Hr96 NR1J1 CG11783 Drosophila melanogaster (Fruit fly) TR35507_c1_g7_i4 Q96RI1 NR1H4_HUMAN 7.00E-26 GO:0000980; GO:0003705; GO:0001190; GO:0008206; GO:0038181; GO:0071229; GO:1902122; GO:0048565; GO:0038185; GO:0004879; GO:0016922; GO:0070858; GO:0000122; GO:0001080; GO:0005719; GO:0005654; GO:0042277; GO:2001250; GO:2000213; GO:0006109; GO:0090181; GO:0034255; GO:0009749; GO:0032496; GO:0003707; GO:0004887; GO:0003713; GO:0003714; GO:0006367; GO:0008270 RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; bile acid metabolic process; bile acid receptor activity; cellular response to acid; chenodeoxycholic acid binding; digestive tract development; intracellular bile acid receptor signaling pathway; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; ligand-dependent nuclear receptor binding; negative regulation of bile acid biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; nitrogen catabolite activation of transcription from RNA polymerase II promoter; nuclear euchromatin; nucleoplasm; peptide binding; positive regulation of ammonia assimilation cycle; positive regulation of glutamate metabolic process; regulation of carbohydrate metabolic process; regulation of cholesterol metabolic process; regulation of urea metabolic process; response to glucose stimulus; response to lipopolysaccharide; steroid hormone receptor activity; thyroid hormone receptor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; zinc ion binding IPR008946; IPR000536; IPR001723; IPR001728; IPR001628; IPR013088; Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14) NR1H4 BAR FXR HRR1 RIP14 Homo sapiens (Human) TR35507_c1_g7_i5 Q62735 NR1H4_RAT 1.00E-26 GO:0003677; GO:0000980; GO:0003705; GO:0001190; GO:0032052; GO:0008206; GO:0038181; GO:0071229; GO:0071417; GO:1902122; GO:0048565; GO:0038185; GO:0070858; GO:0000122; GO:0005719; GO:0005634; GO:0042277; GO:2001250; GO:0045944; GO:0006109; GO:0034255; GO:0009749; GO:0032496; GO:0003707; GO:0004887; GO:0008270 DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; bile acid binding; bile acid metabolic process; bile acid receptor activity; cellular response to acid; cellular response to organonitrogen compound; chenodeoxycholic acid binding; digestive tract development; intracellular bile acid receptor signaling pathway; negative regulation of bile acid biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; nuclear euchromatin; nucleus; peptide binding; positive regulation of ammonia assimilation cycle; positive regulation of transcription from RNA polymerase II promoter; regulation of carbohydrate metabolic process; regulation of urea metabolic process; response to glucose stimulus; response to lipopolysaccharide; steroid hormone receptor activity; thyroid hormone receptor activity; zinc ion binding IPR008946; IPR000536; IPR001723; IPR001728; IPR001628; IPR013088; Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14) Nr1h4 Bar Fxr Rip14 Rattus norvegicus (Rat) TR35507_c1_g7_i6 Q24143 HR96_DROME 1.00E-35 GO:0000977; GO:0042632; GO:0004879; GO:0005634; GO:0070873; GO:0042594; GO:0003707; GO:0070328; GO:0008270 RNA polymerase II regulatory region sequence-specific DNA binding; cholesterol homeostasis; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleus; regulation of glycogen metabolic process; response to starvation; steroid hormone receptor activity; triglyceride homeostasis; zinc ion binding IPR008946; IPR000536; IPR001628; IPR013088; Nuclear hormone receptor HR96 (dHR96) (Nuclear receptor subfamily 1 group J member 1) Hr96 NR1J1 CG11783 Drosophila melanogaster (Fruit fly) TR35508_c0_g3_i2 Q5BKT4 AG10A_HUMAN 1.00E-73 GO:0006488; GO:0005789; GO:0016021; GO:0043687; GO:0018279; GO:0016758 "dolichol-linked oligosaccharide biosynthetic process; endoplasmic reticulum membrane; integral to membrane; post-translational protein modification; protein N-linked glycosylation via asparagine; transferase activity, transferring hexosyl groups" IPR016900; Protein modification; protein glycosylation. "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (EC 2.4.1.256) (Alpha-1,2-glucosyltransferase ALG10-A) (Alpha-2-glucosyltransferase ALG10-A) (Asparagine-linked glycosylation protein 10 homolog A)" ALG10 ALG10A Homo sapiens (Human) TR35508_c0_g3_i3 Q6CEA5 ALG10_YARLI 1.00E-32 GO:0005789; GO:0016021; GO:0006486; GO:0016758 "endoplasmic reticulum membrane; integral to membrane; protein glycosylation; transferase activity, transferring hexosyl groups" IPR016900; Protein modification; protein glycosylation. "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (EC 2.4.1.256) (Alpha-1,2-glucosyltransferase ALG10-A) (Alpha-2-glucosyltransferase ALG10) (Asparagine-linked glycosylation protein 10) (Dolichyl-phosphoglucose-dependent glucosyltransferase ALG10)" ALG10 YALI0B17226g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR35508_c0_g4_i1 Q4P2W6 ALG10_USTMA 6.00E-10 GO:0005789; GO:0016021; GO:0006486; GO:0016758 "endoplasmic reticulum membrane; integral to membrane; protein glycosylation; transferase activity, transferring hexosyl groups" IPR016900; Protein modification; protein glycosylation. "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (EC 2.4.1.256) (Alpha-1,2-glucosyltransferase ALG10-A) (Alpha-2-glucosyltransferase ALG10) (Asparagine-linked glycosylation protein 10) (Dolichyl-phosphoglucose-dependent glucosyltransferase ALG10)" ALG10 UM05547 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR35509_c1_g3_i1 Q6ZN80 MGAL1_HUMAN 9.00E-113 GO:0030246; GO:0005975; GO:0004553 "carbohydrate binding; carbohydrate metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds" IPR011013; IPR000322; IPR017853; Putative maltase-glucoamylase-like protein FLJ16351 (EC 3.2.1.-) Homo sapiens (Human) TR35509_c1_g3_i2 P31434 XYLS_ECOLI 2.00E-13 GO:0030246; GO:0005975; GO:0080176 P0A6F5; P0AF28 "carbohydrate binding; carbohydrate metabolic process; xyloglucan 1,6-alpha-xylosidase activity" IPR013785; IPR011013; IPR000322; IPR025887; IPR017853; Alpha-xylosidase (EC 3.2.1.177) yicI b3656 JW3631 Escherichia coli (strain K12) TR35510_c0_g1_i3 Q8I7P9 POL5_DROME 5.00E-93 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0090305; GO:0005634; GO:0008233; GO:0006508; GO:0006313 "DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus; peptidase activity; proteolysis; transposition, DNA-mediated" IPR001584; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon opus [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR35510_c0_g1_i4 P04323 POL3_DROME 6.00E-96 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR35516_c1_g1_i3 P43118 PF2R_RAT 2.00E-33 GO:0005737; GO:0005576; GO:0016021; GO:0043066; GO:0005886; GO:0004958; GO:0032496 cytoplasm; extracellular region; integral to membrane; negative regulation of apoptotic process; plasma membrane; prostaglandin F receptor activity; response to lipopolysaccharide IPR000276; IPR017452; IPR000141; IPR008365; Prostaglandin F2-alpha receptor (PGF receptor) (PGF2-alpha receptor) (Prostanoid FP receptor) Ptgfr Rattus norvegicus (Rat) TR35516_c1_g2_i1 Q28691 PE2R4_RABIT 3.00E-57 GO:0042093; GO:0007188; GO:0071260; GO:0016021; GO:0050710; GO:2000420; GO:0050728; GO:0033624; GO:0005886; GO:0050715; GO:0050729; GO:0004957; GO:0051492 T-helper cell differentiation; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; cellular response to mechanical stimulus; integral to membrane; negative regulation of cytokine secretion; negative regulation of eosinophil extravasation; negative regulation of inflammatory response; negative regulation of integrin activation; plasma membrane; positive regulation of cytokine secretion; positive regulation of inflammatory response; prostaglandin E receptor activity; regulation of stress fiber assembly IPR000276; IPR017452; IPR001758; IPR008365; IPR001244; Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 Oryctolagus cuniculus (Rabbit) TR35516_c1_g4_i1 Q28691 PE2R4_RABIT 1.00E-13 GO:0042093; GO:0007188; GO:0071260; GO:0016021; GO:0050710; GO:2000420; GO:0050728; GO:0033624; GO:0005886; GO:0050715; GO:0050729; GO:0004957; GO:0051492 T-helper cell differentiation; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; cellular response to mechanical stimulus; integral to membrane; negative regulation of cytokine secretion; negative regulation of eosinophil extravasation; negative regulation of inflammatory response; negative regulation of integrin activation; plasma membrane; positive regulation of cytokine secretion; positive regulation of inflammatory response; prostaglandin E receptor activity; regulation of stress fiber assembly IPR000276; IPR017452; IPR001758; IPR008365; IPR001244; Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 Oryctolagus cuniculus (Rabbit) TR35520_c1_g1_i1 Q08DP0 PGM1_BOVIN 5.00E-110 GO:0005829; GO:0019388; GO:0006006; GO:0005978; GO:0000287; GO:0004614 cytosol; galactose catabolic process; glucose metabolic process; glycogen biosynthetic process; magnesium ion binding; phosphoglucomutase activity IPR005844; IPR016055; IPR005845; IPR005846; IPR005843; IPR016066; IPR005841; Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) PGM1 Bos taurus (Bovine) TR35520_c1_g2_i2 Q4R5E4 PGM1_MACFA 1.00E-102 GO:0005737; GO:0006006; GO:0000287; GO:0004614 cytoplasm; glucose metabolic process; magnesium ion binding; phosphoglucomutase activity IPR005844; IPR016055; IPR005845; IPR005846; IPR005843; IPR016066; IPR005841; Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) PGM1 QnpA-16101 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR35521_c4_g1_i1 Q9GKU5 HDA11_MACFA 3.00E-168 GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0005737; GO:0070932; GO:0070933; GO:0004407; GO:0000118; GO:0006355; GO:0008134; GO:0006351 "NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); cytoplasm; histone H3 deacetylation; histone H4 deacetylation; histone deacetylase activity; histone deacetylase complex; regulation of transcription, DNA-dependent; transcription factor binding; transcription, DNA-dependent" IPR000286; IPR023801; Histone deacetylase 11 (HD11) (EC 3.5.1.98) HDAC11 QccE-18183 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR35522_c2_g2_i1 P79007 HAP5_SCHPO 5.00E-31 GO:0016602; GO:0001077; GO:0000785; GO:0005737; GO:0005634; GO:0006109; GO:0043565 CCAAT-binding factor complex; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; chromatin; cytoplasm; nucleus; regulation of carbohydrate metabolic process; sequence-specific DNA binding IPR003958; IPR009072; IPR027170; Transcriptional activator hap5 hap5 php5 SPBC3B8.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR35522_c2_g2_i2 Q5RA23 NFYC_PONAB 9.00E-59 GO:0016602; GO:0045893; GO:0043565; GO:0003700; GO:0006351 "CCAAT-binding factor complex; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR003958; IPR009072; IPR027170; Nuclear transcription factor Y subunit gamma (CAAT box DNA-binding protein subunit C) (Nuclear transcription factor Y subunit C) (NF-YC) NFYC Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35525_c0_g1_i1 P76464 YFAS_ECOLI 8.00E-06 GO:0004866; GO:0010951 endopeptidase inhibitor activity; negative regulation of endopeptidase activity IPR002890; IPR011625; IPR001599; IPR008930; Putative UPF0192 protein YfaS yfaS yfaR b4500 JW2221/JW2222 b2227/b2228 Escherichia coli (strain K12) TR35525_c0_g2_i1 Q6YHK3 CD109_HUMAN 1.00E-136 GO:0031225; GO:0005615; GO:0010951; GO:0005886; GO:0004867 anchored to membrane; extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) TR35525_c0_g3_i1 Q91132 CO3_NAJKA 3.00E-06 GO:0006956; GO:0004866; GO:0005615; GO:0006954; GO:0046872; GO:0010951 P01031 complement activation; endopeptidase inhibitor activity; extracellular space; inflammatory response; metal ion binding; negative regulation of endopeptidase activity IPR009048; IPR011626; IPR002890; IPR011625; IPR000020; IPR018081; IPR001840; IPR001599; IPR019742; IPR019565; IPR001134; IPR018933; IPR008930; IPR008993; Cobra venom factor (CVF) (CVFk) (Complement C3 homolog) [Cleaved into: Cobra venom factor alpha chain; Cobra venom factor gamma chain; Cobra venom factor beta chain] Naja kaouthia (Monocled cobra) (Naja siamensis) TR35525_c0_g4_i1 Q6YHK3 CD109_HUMAN 9.00E-18 GO:0031225; GO:0005615; GO:0010951; GO:0005886; GO:0004867 anchored to membrane; extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) TR35529_c0_g1_i1 O88544 CSN4_MOUSE 0 GO:0008180; GO:0010388; GO:0005737 Q9QXJ2 COP9 signalosome; cullin deneddylation; cytoplasm IPR000717; IPR011991; COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) Cops4 Csn4 Mus musculus (Mouse) TR35530_c0_g1_i3 Q6NZQ8 MARH1_MOUSE 3.00E-13 GO:0005794; GO:0042287; GO:0002495; GO:0030659; GO:0031901; GO:0005789; GO:0006955; GO:0016021; GO:0031902; GO:0005765; GO:0005886; GO:0000209; GO:0032588; GO:0004842; GO:0008270 Golgi apparatus; MHC protein binding; antigen processing and presentation of peptide antigen via MHC class II; cytoplasmic vesicle membrane; early endosome membrane; endoplasmic reticulum membrane; immune response; integral to membrane; late endosome membrane; lysosomal membrane; plasma membrane; protein polyubiquitination; trans-Golgi network membrane; ubiquitin-protein ligase activity; zinc ion binding IPR011016; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MARCH1 (EC 6.3.2.-) (Membrane-associated RING finger protein 1) (Membrane-associated RING-CH protein I) (MARCH-I) 1-Mar Mus musculus (Mouse) TR35531_c3_g2_i1 Q6AYY8 ACATN_RAT 2.00E-71 GO:0008521; GO:0007417; GO:0005789; GO:0016021 acetyl-CoA transporter activity; central nervous system development; endoplasmic reticulum membrane; integral to membrane IPR024371; IPR004752; IPR016196; Acetyl-coenzyme A transporter 1 (AT-1) (Acetyl-CoA transporter 1) (Solute carrier family 33 member 1) Slc33a1 Acatn Rattus norvegicus (Rat) TR35532_c0_g1_i1 O42123 FKB1A_XENLA 2.00E-51 GO:0005737; GO:0003755; GO:0006457; GO:0000413 cytoplasm; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR023566; IPR001179; Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) fkbp1a Xenopus laevis (African clawed frog) TR35533_c1_g2_i2 Q3T100 MGST3_BOVIN 3.00E-36 GO:0005783; GO:0005789; GO:0004602; GO:0004364; GO:0016021; GO:0005635 endoplasmic reticulum; endoplasmic reticulum membrane; glutathione peroxidase activity; glutathione transferase activity; integral to membrane; nuclear envelope IPR023352; IPR001129; Microsomal glutathione S-transferase 3 (Microsomal GST-3) (EC 2.5.1.18) MGST3 Bos taurus (Bovine) TR35533_c1_g2_i3 Q3T100 MGST3_BOVIN 1.00E-30 GO:0005783; GO:0005789; GO:0004602; GO:0004364; GO:0016021; GO:0005635 endoplasmic reticulum; endoplasmic reticulum membrane; glutathione peroxidase activity; glutathione transferase activity; integral to membrane; nuclear envelope IPR023352; IPR001129; Microsomal glutathione S-transferase 3 (Microsomal GST-3) (EC 2.5.1.18) MGST3 Bos taurus (Bovine) TR35534_c0_g1_i1 Q6DFH5 SH3Y1_XENLA 2.00E-77 IPR001452; IPR007461; SH3 domain-containing YSC84-like protein 1 sh3yl1 Xenopus laevis (African clawed frog) TR35534_c0_g1_i2 Q3SZ01 SH3Y1_BOVIN 1.00E-93 IPR001452; IPR007461; SH3 domain-containing YSC84-like protein 1 SH3YL1 Bos taurus (Bovine) TR35534_c0_g1_i3 A4FU49 SH321_HUMAN 3.00E-07 IPR011511; IPR001452; IPR013315; SH3 domain-containing protein 21 SH3D21 C1orf113 Homo sapiens (Human) TR35535_c0_g1_i1 Q69ZF3 GBA2_MOUSE 9.00E-174 GO:0000139; GO:0008422; GO:0021954; GO:0005789; GO:0004348; GO:0006680; GO:0016021 Golgi membrane; beta-glucosidase activity; central nervous system neuron development; endoplasmic reticulum membrane; glucosylceramidase activity; glucosylceramide catabolic process; integral to membrane IPR008928; IPR014551; IPR024462; IPR006775; Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Glucosylceramidase 2) Gba2 Kiaa1605 Mus musculus (Mouse) TR35535_c0_g1_i3 Q69ZF3 GBA2_MOUSE 1.00E-67 GO:0000139; GO:0008422; GO:0021954; GO:0005789; GO:0004348; GO:0006680; GO:0016021 Golgi membrane; beta-glucosidase activity; central nervous system neuron development; endoplasmic reticulum membrane; glucosylceramidase activity; glucosylceramide catabolic process; integral to membrane IPR008928; IPR014551; IPR024462; IPR006775; Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Glucosylceramidase 2) Gba2 Kiaa1605 Mus musculus (Mouse) TR35537_c1_g1_i1 Q6AXJ2 EI3HA_DANRE 1.00E-77 GO:0007420; GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0048882; GO:0006417; GO:0006446; GO:0003743; GO:0006413; GO:0001944 brain development; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; lateral line development; regulation of translation; regulation of translational initiation; translation initiation factor activity; translational initiation; vasculature development IPR027524; IPR000555; Eukaryotic translation initiation factor 3 subunit H-A (eIF3h-A) (Eukaryotic translation initiation factor 3 subunit 3-A) (eIF-3-gamma-A) (eIF3 p40 subunit A) eif3ha eif3h eif3s3a Danio rerio (Zebrafish) (Brachydanio rerio) TR35537_c1_g1_i2 Q5BDW0 EIF3H_EMENI 3.00E-32 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0006446; GO:0003743 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; regulation of translational initiation; translation initiation factor activity IPR027524; IPR000555; Eukaryotic translation initiation factor 3 subunit H (eIF3h) AN1270 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR35539_c2_g1_i1 A7SMW7 L2HDH_NEMVE 0 GO:0047545; GO:0005739 2-hydroxyglutarate dehydrogenase activity; mitochondrion IPR006076; "L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.2)" v1g172254 Nematostella vectensis (Starlet sea anemone) TR35539_c2_g1_i2 A8X2R1 L2HDH_CAEBR 9.00E-173 GO:0047545; GO:0005739 2-hydroxyglutarate dehydrogenase activity; mitochondrion IPR006076; "L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.2)" CBG06643 Caenorhabditis briggsae TR35543_c0_g2_i1 Q9EPK6 SIL1_MOUSE 3.00E-66 GO:0005783; GO:0005788; GO:0015031 endoplasmic reticulum; endoplasmic reticulum lumen; protein transport IPR011989; IPR016024; Nucleotide exchange factor SIL1 Sil1 Mus musculus (Mouse) TR35543_c0_g2_i2 Q9VBV5 SIL1_DROME 4.00E-26 GO:0006616; GO:0005783; GO:0005788 "SRP-dependent cotranslational protein targeting to membrane, translocation; endoplasmic reticulum; endoplasmic reticulum lumen" IPR011989; IPR016024; Nucleotide exchange factor SIL1 CG10420 Drosophila melanogaster (Fruit fly) TR35543_c0_g5_i3 Q99158 SIL1_YARLI 1.00E-08 GO:0005788; GO:0015031 endoplasmic reticulum lumen; protein transport IPR011989; IPR016024; Nucleotide exchange factor SIL1 (Protein SLS1) SIL1 SLS1 YALI0E32703g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR35543_c0_g5_i4 Q5A360 SIL1_CANAL 4.00E-09 GO:0005788; GO:0015031 endoplasmic reticulum lumen; protein transport IPR016024; Nucleotide exchange factor SIL1 SIL1 CaO19.13761 CaO19.6403 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) TR35544_c0_g1_i1 O95872 GPAN1_HUMAN 5.00E-39 GO:0003676 nucleic acid binding IPR002110; IPR020683; IPR000467; G patch domain and ankyrin repeat-containing protein 1 (Ankyrin repeat domain-containing protein 59) (G patch domain-containing protein 10) (HLA-B-associated transcript 4) (Protein G5) GPANK1 ANKRD59 BAT4 G5 GPATCH10 Homo sapiens (Human) TR35544_c0_g1_i2 O95872 GPAN1_HUMAN 3.00E-39 GO:0003676 nucleic acid binding IPR002110; IPR020683; IPR000467; G patch domain and ankyrin repeat-containing protein 1 (Ankyrin repeat domain-containing protein 59) (G patch domain-containing protein 10) (HLA-B-associated transcript 4) (Protein G5) GPANK1 ANKRD59 BAT4 G5 GPATCH10 Homo sapiens (Human) TR3555_c0_g1_i1 Q5ZM14 NHRF1_CHICK 1.00E-11 GO:0016055; GO:0032782; GO:0017081; GO:0005737; GO:0012505; GO:0030175; GO:0034635; GO:0031528; GO:2000146; GO:0014067; GO:0010642; GO:0051898; GO:0045859; GO:0070293; GO:0001726 Wnt receptor signaling pathway; bile acid secretion; chloride channel regulator activity; cytoplasm; endomembrane system; filopodium; glutathione transport; microvillus membrane; negative regulation of cell motility; negative regulation of phosphatidylinositol 3-kinase cascade; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein kinase B signaling cascade; regulation of protein kinase activity; renal absorption; ruffle IPR015098; IPR017300; IPR001478; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) SLC9A3R1 NHERF NHERF1 RCJMB04_3g21 Gallus gallus (Chicken) TR35551_c0_g1_i1 Q54P23 SDF2_DICDI 2.00E-21 GO:0005576; GO:0016020 extracellular region; membrane IPR027005; IPR016093; Stromal cell-derived factor 2-like protein (SDF2-like protein) DDB_G0284847 Dictyostelium discoideum (Slime mold) TR35551_c0_g1_i5 Q3SZ45 SDF2_BOVIN 3.00E-57 GO:0005576; GO:0016020 extracellular region; membrane IPR027005; IPR016093; Stromal cell-derived factor 2 (SDF-2) SDF2 Bos taurus (Bovine) TR35551_c0_g1_i7 P31382 PMT2_YEAST 3.00E-06 GO:0071712; GO:0004169; GO:0031502; GO:0016021; GO:0035269; GO:0032527; GO:1900101 P33775 ER-associated misfolded protein catabolic process; dolichyl-phosphate-mannose-protein mannosyltransferase activity; dolichyl-phosphate-mannose-protein mannosyltransferase complex; integral to membrane; protein O-linked mannosylation; protein exit from endoplasmic reticulum; regulation of endoplasmic reticulum unfolded protein response IPR027005; IPR003342; IPR016093; Protein modification; protein glycosylation. Dolichyl-phosphate-mannose--protein mannosyltransferase 2 (EC 2.4.1.109) PMT2 YAL023C FUN25 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR35552_c0_g1_i1 Q03147 CDK7_MOUSE 3.00E-120 GO:0005524; GO:0006281; GO:0008094; GO:0008353; GO:0051301; GO:0004693; GO:0005675; GO:0048471; GO:0045944; GO:0006366 ATP binding; DNA repair; DNA-dependent ATPase activity; RNA polymerase II carboxy-terminal domain kinase activity; cell division; cyclin-dependent protein serine/threonine kinase activity; holo TFIIH complex; perinuclear region of cytoplasm; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (P39 Mo15) (CDK-activating kinase) (CR4 protein kinase) (CRK4) (Cell division protein kinase 7) (Protein-tyrosine kinase MPK-7) (TFIIH basal transcription factor complex kinase subunit) Cdk7 Cak Cdkn7 Crk4 Mo15 Mpk-7 Mus musculus (Mouse) TR35552_c0_g1_i3 Q03147 CDK7_MOUSE 1.00E-91 GO:0005524; GO:0006281; GO:0008094; GO:0008353; GO:0051301; GO:0004693; GO:0005675; GO:0048471; GO:0045944; GO:0006366 ATP binding; DNA repair; DNA-dependent ATPase activity; RNA polymerase II carboxy-terminal domain kinase activity; cell division; cyclin-dependent protein serine/threonine kinase activity; holo TFIIH complex; perinuclear region of cytoplasm; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (P39 Mo15) (CDK-activating kinase) (CR4 protein kinase) (CRK4) (Cell division protein kinase 7) (Protein-tyrosine kinase MPK-7) (TFIIH basal transcription factor complex kinase subunit) Cdk7 Cak Cdkn7 Crk4 Mo15 Mpk-7 Mus musculus (Mouse) TR35554_c0_g1_i1 P34631 UBXN4_CAEEL 2.00E-15 IPR001012; UBX domain-containing protein 4 ubxn-4 ZK353.8 Caenorhabditis elegans TR35554_c0_g1_i3 Q5R4I3 UBXN4_PONAB 4.00E-50 GO:0005789; GO:0005635; GO:0006986 endoplasmic reticulum membrane; nuclear envelope; response to unfolded protein IPR012336; IPR001012; UBX domain-containing protein 4 (UBX domain-containing protein 2) UBXN4 UBXD2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35554_c0_g1_i4 Q5R4I3 UBXN4_PONAB 6.00E-24 GO:0005789; GO:0005635; GO:0006986 endoplasmic reticulum membrane; nuclear envelope; response to unfolded protein IPR012336; IPR001012; UBX domain-containing protein 4 (UBX domain-containing protein 2) UBXN4 UBXD2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35555_c1_g1_i1 Q969U6 FBXW5_HUMAN 2.00E-29 GO:0080008; GO:0019005; GO:0031146; GO:0051298; GO:0005737; GO:0007067; GO:0016567 P63208 Cul4-RING ubiquitin ligase complex; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; centrosome duplication; cytoplasm; mitosis; protein ubiquitination IPR001810; IPR015943; IPR001680; IPR017986; Protein modification; protein ubiquitination. F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) FBXW5 FBW5 PP3971 Homo sapiens (Human) TR35556_c3_g1_i1 A1L259 URAD_DANRE 1.00E-55 GO:0019428; GO:0016831; GO:0005777; GO:0006144; GO:0019628 allantoin biosynthetic process; carboxy-lyase activity; peroxisome; purine nucleobase metabolic process; urate catabolic process IPR018020; IPR017580; Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3. 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (OHCU decarboxylase) (EC 4.1.1.n1) (Parahox neighbor) (Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase) urad prhoxnb zgc:158663 Danio rerio (Zebrafish) (Brachydanio rerio) TR35556_c3_g1_i5 A1L259 URAD_DANRE 2.00E-55 GO:0019428; GO:0016831; GO:0005777; GO:0006144; GO:0019628 allantoin biosynthetic process; carboxy-lyase activity; peroxisome; purine nucleobase metabolic process; urate catabolic process IPR018020; IPR017580; Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3. 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (OHCU decarboxylase) (EC 4.1.1.n1) (Parahox neighbor) (Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase) urad prhoxnb zgc:158663 Danio rerio (Zebrafish) (Brachydanio rerio) TR35558_c0_g1_i1 Q3ZBG7 SRP19_BOVIN 7.00E-30 GO:0008312; GO:0006614; GO:0005739; GO:0005730; GO:0042493; GO:0005786 "7S RNA binding; SRP-dependent cotranslational protein targeting to membrane; mitochondrion; nucleolus; response to drug; signal recognition particle, endoplasmic reticulum targeting" IPR002778; Signal recognition particle 19 kDa protein (SRP19) SRP19 Bos taurus (Bovine) TR35558_c0_g1_i2 P49963 SRP19_DROME 2.00E-32 GO:0008312; GO:0006614; GO:0005786 "7S RNA binding; SRP-dependent cotranslational protein targeting to membrane; signal recognition particle, endoplasmic reticulum targeting" IPR002778; Signal recognition particle 19 kDa protein (SRP19) Srp19 CG4457 Drosophila melanogaster (Fruit fly) TR35559_c0_g1_i1 Q684M4 KEAP1_PIG 3.00E-178 GO:0031463; GO:0005737; GO:0005634; GO:0010499; GO:0016567; GO:0006355; GO:0006351 "Cul3-RING ubiquitin ligase complex; cytoplasm; nucleus; proteasomal ubiquitin-independent protein catabolic process; protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) KEAP1 INRF2 Sus scrofa (Pig) TR35560_c1_g1_i1 Q8TB52 FBX30_HUMAN 2.00E-46 GO:0004842; GO:0008270 ubiquitin-protein ligase activity; zinc ion binding IPR001810; IPR013323; IPR008974; IPR001293; F-box only protein 30 FBXO30 FBX30 Homo sapiens (Human) TR35560_c1_g1_i3 Q5XI67 FBX30_RAT 1.00E-24 GO:0004842; GO:0008270 ubiquitin-protein ligase activity; zinc ion binding IPR001810; IPR013323; IPR008974; IPR001293; F-box only protein 30 Fbxo30 Rattus norvegicus (Rat) TR35562_c0_g2_i1 A7DZP8 GPDM_MESAU 4.00E-06 GO:0005509; GO:0019563; GO:0009331; GO:0006072; GO:0005739; GO:0052591 calcium ion binding; glycerol catabolic process; glycerol-3-phosphate dehydrogenase complex; glycerol-3-phosphate metabolic process; mitochondrion; sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity IPR011992; IPR018247; IPR002048; IPR006076; IPR000447; Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (aerobic route): step 1/1. "Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD-M) (GPDH-M) (EC 1.1.5.3) (mGPD)" GPD2 Mesocricetus auratus (Golden hamster) TR35562_c0_g2_i2 Q42479 CDPK3_ARATH 7.00E-12 GO:0005524; GO:0009738; GO:0005509; GO:0005829; GO:0005634; GO:0005886; GO:0046777; GO:0004674; GO:0010359; GO:0010119; GO:0009651; GO:0005773 Q03509; P59220 ATP binding; abscisic acid mediated signaling pathway; calcium ion binding; cytosol; nucleus; plasma membrane; protein autophosphorylation; protein serine/threonine kinase activity; regulation of anion channel activity; regulation of stomatal movement; response to salt stress; vacuole IPR011992; IPR018247; IPR002048; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium-dependent protein kinase 3 (EC 2.7.11.1) (Calcium-dependent protein kinase isoform CDPK6) (AtCDPK6) CPK3 CDPK6 At4g23650 F9D16.120 Arabidopsis thaliana (Mouse-ear cress) TR35564_c0_g2_i1 Q9CZJ2 HS12B_MOUSE 5.00E-13 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR35565_c0_g1_i1 Q6KC79 NIPBL_HUMAN 2.00E-154 GO:0032116; GO:0007420; GO:0034613; GO:0071481; GO:0003682; GO:0050890; GO:0048589; GO:0042471; GO:0048557; GO:0035115; GO:0048703; GO:0035261; GO:0048592; GO:0060325; GO:0045444; GO:0061010; GO:0034088; GO:0001656; GO:0000122; GO:0005654; GO:0003151; GO:0031065; GO:0040018; GO:0045778; GO:0048638; GO:0045995; GO:0042634; GO:0006974; GO:0007605; GO:0019827; GO:0061038 SMC loading complex; brain development; cellular protein localization; cellular response to X-ray; chromatin binding; cognition; developmental growth; ear morphogenesis; embryonic digestive tract morphogenesis; embryonic forelimb morphogenesis; embryonic viscerocranium morphogenesis; external genitalia morphogenesis; eye morphogenesis; face morphogenesis; fat cell differentiation; gall bladder development; maintenance of mitotic sister chromatid cohesion; metanephros development; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; outflow tract morphogenesis; positive regulation of histone deacetylation; positive regulation of multicellular organism growth; positive regulation of ossification; regulation of developmental growth; regulation of embryonic development; regulation of hair cycle; response to DNA damage stimulus; sensory perception of sound; stem cell maintenance; uterus morphogenesis IPR011989; IPR016024; IPR026003; IPR024986; Nipped-B-like protein (Delangin) (SCC2 homolog) NIPBL IDN3 Homo sapiens (Human) TR35565_c2_g2_i2 Q6KCD5 NIPBL_MOUSE 2.00E-110 GO:0032116; GO:0007420; GO:0034613; GO:0071481; GO:0003682; GO:0050890; GO:0048589; GO:0042471; GO:0048557; GO:0035115; GO:0048703; GO:0035261; GO:0048592; GO:0060325; GO:0045444; GO:0061010; GO:0007507; GO:0034088; GO:0036033; GO:0000122; GO:0003151; GO:0031065; GO:0040018; GO:0045778; GO:0048638; GO:0045995; GO:0042634; GO:0006974; GO:0007605; GO:0019827; GO:0061038 SMC loading complex; brain development; cellular protein localization; cellular response to X-ray; chromatin binding; cognition; developmental growth; ear morphogenesis; embryonic digestive tract morphogenesis; embryonic forelimb morphogenesis; embryonic viscerocranium morphogenesis; external genitalia morphogenesis; eye morphogenesis; face morphogenesis; fat cell differentiation; gall bladder development; heart development; maintenance of mitotic sister chromatid cohesion; mediator complex binding; negative regulation of transcription from RNA polymerase II promoter; outflow tract morphogenesis; positive regulation of histone deacetylation; positive regulation of multicellular organism growth; positive regulation of ossification; regulation of developmental growth; regulation of embryonic development; regulation of hair cycle; response to DNA damage stimulus; sensory perception of sound; stem cell maintenance; uterus morphogenesis IPR011989; IPR016024; IPR026003; IPR024986; Nipped-B-like protein (Delangin homolog) (SCC2 homolog) Nipbl Mus musculus (Mouse) TR35566_c0_g2_i1 Q3SZK1 AAMP_BOVIN 9.00E-117 GO:0001525; GO:0030154; GO:0009986; GO:0005737; GO:0005886; GO:0045766; GO:0010595; GO:0014909 angiogenesis; cell differentiation; cell surface; cytoplasm; plasma membrane; positive regulation of angiogenesis; positive regulation of endothelial cell migration; smooth muscle cell migration IPR015943; IPR001680; IPR019775; IPR017986; Angio-associated migratory cell protein AAMP Bos taurus (Bovine) TR35567_c0_g1_i1 C3YWU0 FUCO_BRAFL 1.00E-87 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR35568_c0_g1_i1 Q9V3D2 HEM6_DROME 7.00E-164 GO:0004109; GO:0042803; GO:0006782 P15330-2 coproporphyrinogen oxidase activity; protein homodimerization activity; protoporphyrinogen IX biosynthetic process IPR001260; IPR018375; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. Coproporphyrinogen-III oxidase (COX) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3) Coprox CG3433 Drosophila melanogaster (Fruit fly) TR35568_c0_g1_i2 Q9V3D2 HEM6_DROME 4.00E-163 GO:0004109; GO:0042803; GO:0006782 P15330-2 coproporphyrinogen oxidase activity; protein homodimerization activity; protoporphyrinogen IX biosynthetic process IPR001260; IPR018375; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. Coproporphyrinogen-III oxidase (COX) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3) Coprox CG3433 Drosophila melanogaster (Fruit fly) TR35569_c1_g1_i12 Q3BAI2 YCX91_PHAAO 6.00E-10 GO:0009507 chloroplast Uncharacterized protein ORF91 Phalaenopsis aphrodite subsp. formosana (Moth orchid) TR35574_c0_g3_i1 Q29IK4 RM22_DROPS 4.00E-51 GO:0015934; GO:0005739; GO:0003735; GO:0006412 large ribosomal subunit; mitochondrion; structural constituent of ribosome; translation IPR001063; IPR005727; "39S ribosomal protein L22, mitochondrial (L22mt) (MRP-L22)" mRpL22 GA18397 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR35574_c0_g3_i2 Q92QG5 RL22_RHIME 4.00E-07 GO:0015934; GO:0019843; GO:0003735; GO:0006412 large ribosomal subunit; rRNA binding; structural constituent of ribosome; translation IPR001063; IPR018260; IPR005727; 50S ribosomal protein L22 rplV R01361 SMc01304 Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) TR35575_c0_g1_i1 Q5ZJJ8 UBCP1_CHICK 2.00E-134 GO:0005634; GO:0004721 nucleus; phosphoprotein phosphatase activity IPR023214; IPR011943; IPR004274; IPR000626; Ubiquitin-like domain-containing CTD phosphatase 1 (EC 3.1.3.16) (Nuclear proteasome inhibitor UBLCP1) UBLCP1 RCJMB04_17j14 Gallus gallus (Chicken) TR35576_c1_g1_i1 A5A4K9 GHSR_RABIT 1.00E-16 GO:0008154; GO:0008343; GO:0009986; GO:0032869; GO:0046697; GO:0001616; GO:0030252; GO:0016520; GO:0009755; GO:0016021; GO:0045121; GO:0050728; GO:0032691; GO:0045409; GO:0042536; GO:0043005; GO:0005886; GO:0032100; GO:0043568; GO:0040018; GO:0051963; GO:0032094 actin polymerization or depolymerization; adult feeding behavior; cell surface; cellular response to insulin stimulus; decidualization; growth hormone secretagogue receptor activity; growth hormone secretion; growth hormone-releasing hormone receptor activity; hormone-mediated signaling pathway; integral to membrane; membrane raft; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 biosynthetic process; negative regulation of tumor necrosis factor biosynthetic process; neuron projection; plasma membrane; positive regulation of appetite; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; regulation of synapse assembly; response to food IPR003905; IPR000276; IPR017452; Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) GHSR Oryctolagus cuniculus (Rabbit) TR35576_c1_g1_i2 P11614 5HT1D_CANFA 2.00E-12 GO:0007193; GO:0005887; GO:0050795; GO:0040012; GO:0004993; GO:0006939; GO:0007268; GO:0042310 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; integral to plasma membrane; regulation of behavior; regulation of locomotion; serotonin receptor activity; smooth muscle contraction; synaptic transmission; vasoconstriction IPR000505; IPR002231; IPR000276; IPR017452; 5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin receptor 1D) HTR1D RDC4 Canis familiaris (Dog) (Canis lupus familiaris) TR35576_c1_g1_i3 P14842 5HT2A_RAT 6.00E-12 GO:0071886; GO:0070371; GO:0001965; GO:0007568; GO:0014824; GO:0030424; GO:0048148; GO:0005901; GO:0070852; GO:0008219; GO:0016023; GO:0005829; GO:0043198; GO:0050966; GO:0050965; GO:0008144; GO:0007204; GO:0005887; GO:0007613; GO:0043267; GO:0051967; GO:0043025; GO:0014065; GO:0006661; GO:0004435; GO:0007208; GO:0005886; GO:0043406; GO:0008284; GO:0045907; GO:0050795; GO:0014059; GO:0046883; GO:0051209; GO:0042493; GO:0051378; GO:0004993; GO:0030431; GO:0001659; GO:0014832 P31421 "1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding; ERK1 and ERK2 cascade; G-protein alpha-subunit binding; aging; artery smooth muscle contraction; axon; behavioral response to cocaine; caveola; cell body fiber; cell death; cytoplasmic membrane-bounded vesicle; cytosol; dendritic shaft; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; drug binding; elevation of cytosolic calcium ion concentration; integral to plasma membrane; memory; negative regulation of potassium ion transport; negative regulation of synaptic transmission, glutamatergic; neuronal cell body; phosphatidylinositol 3-kinase cascade; phosphatidylinositol biosynthetic process; phosphatidylinositol phospholipase C activity; phospholipase C-activating serotonin receptor signaling pathway; plasma membrane; positive regulation of MAP kinase activity; positive regulation of cell proliferation; positive regulation of vasoconstriction; regulation of behavior; regulation of dopamine secretion; regulation of hormone secretion; release of sequestered calcium ion into cytosol; response to drug; serotonin binding; serotonin receptor activity; sleep; temperature homeostasis; urinary bladder smooth muscle contraction" IPR000455; IPR002231; IPR000276; IPR017452; 5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A) Htr2a Htr2 Rattus norvegicus (Rat) TR35578_c4_g1_i3 P08548 LIN1_NYCCO 8.00E-28 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR35578_c4_g1_i4 P08548 LIN1_NYCCO 1.00E-26 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR35580_c0_g1_i1 Q9N0Z4 AT11B_RABIT 1.00E-82 GO:0005524; GO:0019829; GO:0005769; GO:0005783; GO:0016021; GO:0000287; GO:0005637; GO:0004012; GO:0055038 ATP binding; cation-transporting ATPase activity; early endosome; endoplasmic reticulum; integral to membrane; magnesium ion binding; nuclear inner membrane; phospholipid-translocating ATPase activity; recycling endosome membrane IPR023299; IPR018303; IPR006539; IPR008250; IPR001757; IPR023214; Probable phospholipid-transporting ATPase IF (EC 3.6.3.1) (ATPase IR) (ATPase class VI type 11B) (RING finger-binding protein) (Fragment) ATP11B Oryctolagus cuniculus (Rabbit) TR35580_c0_g2_i1 Q9GKS6 AT10D_MACFA 1.00E-19 GO:0005524; GO:0019829; GO:0005789; GO:0016021; GO:0000287; GO:0004012; GO:0005886 ATP binding; cation-transporting ATPase activity; endoplasmic reticulum membrane; integral to membrane; magnesium ion binding; phospholipid-translocating ATPase activity; plasma membrane IPR023299; IPR006539; IPR001757; IPR023214; Probable phospholipid-transporting ATPase VD (EC 3.6.3.1) (ATPase class V type 10D) (Fragment) ATP10D QnpA-21212 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR35580_c1_g1_i1 Q9Y2G3 AT11B_HUMAN 0 GO:0005524; GO:0015917; GO:0019829; GO:0005769; GO:0005783; GO:0016021; GO:0015075; GO:0000287; GO:0005637; GO:0045332; GO:0004012; GO:0005886; GO:0055037; GO:0055038 ATP binding; aminophospholipid transport; cation-transporting ATPase activity; early endosome; endoplasmic reticulum; integral to membrane; ion transmembrane transporter activity; magnesium ion binding; nuclear inner membrane; phospholipid translocation; phospholipid-translocating ATPase activity; plasma membrane; recycling endosome; recycling endosome membrane IPR023299; IPR018303; IPR006539; IPR008250; IPR001757; IPR023214; Probable phospholipid-transporting ATPase IF (EC 3.6.3.1) (ATPase IR) (ATPase class VI type 11B) ATP11B ATPIF ATPIR KIAA0956 Homo sapiens (Human) TR35580_c1_g1_i2 Q9LK90 ALA8_ARATH 1.00E-93 GO:0005524; GO:0019829; GO:0016021; GO:0000287; GO:0004012 ATP binding; cation-transporting ATPase activity; integral to membrane; magnesium ion binding; phospholipid-translocating ATPase activity IPR023299; IPR018303; IPR006539; IPR008250; IPR001757; IPR023214; Putative phospholipid-transporting ATPase 8 (AtALA8) (EC 3.6.3.1) (Aminophospholipid flippase 8) ALA8 At3g27870 K16N12.9 Arabidopsis thaliana (Mouse-ear cress) TR35583_c0_g1_i1 P98164 LRP2_HUMAN 2.00E-66 GO:0005794; GO:0016324; GO:0031526; GO:0005509; GO:0008283; GO:0005905; GO:0030139; GO:0005783; GO:0005768; GO:0030900; GO:0016021; GO:0005765; GO:0007603; GO:0006486; GO:0006898; GO:0001523; GO:0042359 "Golgi apparatus; apical plasma membrane; brush border membrane; calcium ion binding; cell proliferation; coated pit; endocytic vesicle; endoplasmic reticulum; endosome; forebrain development; integral to membrane; lysosomal membrane; phototransduction, visible light; protein glycosylation; receptor-mediated endocytosis; retinoid metabolic process; vitamin D metabolic process" IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; IPR019825; Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) LRP2 Homo sapiens (Human) TR35583_c0_g1_i2 P98163 YL_DROME 3.00E-78 GO:0005509; GO:0030135; GO:0016021; GO:0048477; GO:0005886; GO:0008196 calcium ion binding; coated vesicle; integral to membrane; oogenesis; plasma membrane; vitellogenin receptor activity IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023415; IPR000033; IPR002172; Putative vitellogenin receptor (Protein yolkless) (YL) yl CG1372 Drosophila melanogaster (Fruit fly) TR35583_c0_g2_i1 O88281 MEGF6_RAT 1.00E-11 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR002049; IPR011489; IPR009030; Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) TR35583_c0_g2_i4 P07522 EGF_RAT 3.00E-22 GO:0007262; GO:0005509; GO:0005154; GO:0007173; GO:0016021; GO:0043388; GO:0050708 STAT protein import into nucleus; calcium ion binding; epidermal growth factor receptor binding; epidermal growth factor receptor signaling pathway; integral to membrane; positive regulation of DNA binding; regulation of protein secretion IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR000033; IPR016317; Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor] Egf Rattus norvegicus (Rat) TR35583_c0_g2_i5 Q8BPB5 FBLN3_MOUSE 3.00E-09 GO:0005509; GO:0005154; GO:0005006; GO:0005615; GO:0032331; GO:0005578; GO:0006355 "calcium ion binding; epidermal growth factor receptor binding; epidermal growth factor-activated receptor activity; extracellular space; negative regulation of chondrocyte differentiation; proteinaceous extracellular matrix; regulation of transcription, DNA-dependent" IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; EGF-containing fibulin-like extracellular matrix protein 1 (Fibulin-3) (FIBL-3) Efemp1 Fbln3 Mus musculus (Mouse) TR35583_c0_g2_i7 Q6X0I2 VGR_SOLIN 4.00E-41 GO:0005509; GO:0016021; GO:0004872; GO:0006898 calcium ion binding; integral to membrane; receptor activity; receptor-mediated endocytosis IPR011042; IPR026823; IPR000742; IPR001881; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Vitellogenin receptor (SiVgR) VgR Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri) TR35583_c0_g2_i8 O35568 FBLN3_RAT 2.00E-10 GO:0005509; GO:0005154; GO:0005006; GO:0005615; GO:0032331; GO:0005578; GO:0006355 "calcium ion binding; epidermal growth factor receptor binding; epidermal growth factor-activated receptor activity; extracellular space; negative regulation of chondrocyte differentiation; proteinaceous extracellular matrix; regulation of transcription, DNA-dependent" IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; EGF-containing fibulin-like extracellular matrix protein 1 (Fibulin-3) (FIBL-3) (T16 protein) Efemp1 Fbln3 Rattus norvegicus (Rat) TR35583_c0_g2_i9 Q6X0I2 VGR_SOLIN 3.00E-41 GO:0005509; GO:0016021; GO:0004872; GO:0006898 calcium ion binding; integral to membrane; receptor activity; receptor-mediated endocytosis IPR011042; IPR026823; IPR000742; IPR001881; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Vitellogenin receptor (SiVgR) VgR Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri) TR35583_c0_g3_i1 Q86YD5 LRAD3_HUMAN 6.00E-16 GO:0001540; GO:0016021; GO:0005886; GO:0006898; GO:0070613 beta-amyloid binding; integral to membrane; plasma membrane; receptor-mediated endocytosis; regulation of protein processing IPR023415; IPR002172; Low-density lipoprotein receptor class A domain-containing protein 3 LDLRAD3 Homo sapiens (Human) TR35584_c1_g1_i1 Q16651 PRSS8_HUMAN 9.00E-35 GO:0005615; GO:0016021; GO:0005886; GO:0010765; GO:0006508; GO:0004252; GO:0008236 extracellular space; integral to membrane; plasma membrane; positive regulation of sodium ion transport; proteolysis; serine-type endopeptidase activity; serine-type peptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Prostasin (EC 3.4.21.-) (Channel-activating protease 1) (CAP1) (Serine protease 8) [Cleaved into: Prostasin light chain; Prostasin heavy chain] PRSS8 Homo sapiens (Human) TR35584_c1_g1_i2 Q9DBI0 TMPS6_MOUSE 9.00E-36 GO:0042730; GO:0016021; GO:0055072; GO:0005886; GO:0006508; GO:0004252 fibrinolysis; integral to membrane; iron ion homeostasis; plasma membrane; proteolysis; serine-type endopeptidase activity IPR000859; IPR002172; IPR017118; IPR001254; IPR018114; IPR001314; IPR000082; IPR009003; Transmembrane protease serine 6 (EC 3.4.21.-) (Matriptase-2) Tmprss6 Mus musculus (Mouse) TR35584_c1_g1_i3 Q9TXD8 ISOHC_AGEAP 1.00E-23 GO:0005576; GO:0016853; GO:0006508; GO:0004252 extracellular region; isomerase activity; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Venom peptide isomerase heavy chain (EC 5.-.-.-) Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi) TR35587_c4_g1_i1 Q9VCA2 ORCT_DROME 3.00E-67 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR35587_c4_g2_i1 Q5RC45 S22AO_PONAB 4.00E-19 GO:0016021; GO:0006811; GO:0022857 integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Solute carrier family 22 member 24 SLC22A24 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35587_c4_g2_i2 Q8WUG5 S22AH_HUMAN 5.00E-08 GO:0031301; GO:0005887; GO:0006811; GO:0015891; GO:0004888; GO:0022857; GO:0005774 integral to organelle membrane; integral to plasma membrane; ion transport; siderophore transport; transmembrane signaling receptor activity; transmembrane transporter activity; vacuolar membrane IPR020846; IPR016196; IPR005828; IPR005829; Solute carrier family 22 member 17 (24p3 receptor) (24p3R) (Brain-type organic cation transporter) (Lipocalin-2 receptor) (Neutrophil gelatinase-associated lipocalin receptor) (NgalR) SLC22A17 BOCT BOIT Homo sapiens (Human) TR35589_c0_g1_i1 Q8BRF7 SCFD1_MOUSE 0 GO:0032580; GO:0017119; GO:0005798; GO:0005801; GO:0005789; GO:0005886; GO:0006892; GO:0015031; GO:0060628; GO:0001666; GO:0009636; GO:0006890; GO:0006904 "Golgi cisterna membrane; Golgi transport complex; Golgi-associated vesicle; cis-Golgi network; endoplasmic reticulum membrane; plasma membrane; post-Golgi vesicle-mediated transport; protein transport; regulation of ER to Golgi vesicle-mediated transport; response to hypoxia; response to toxic substance; retrograde vesicle-mediated transport, Golgi to ER; vesicle docking involved in exocytosis" IPR027482; IPR001619; Sec1 family domain-containing protein 1 (Syntaxin-binding protein 1-like 2) Scfd1 Stxbp1l2 Mus musculus (Mouse) TR35590_c1_g2_i2 Q9VC61 CRERF_DROME 7.00E-39 GO:0005634; GO:0042803; GO:0043565; GO:0003700; GO:0006351 "nucleus; protein homodimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; Protein CREBRF homolog CG13624 Drosophila melanogaster (Fruit fly) TR35592_c0_g2_i1 Q9R016 BIR1E_MOUSE 7.00E-07 GO:0005524; GO:0072557; GO:0006915; GO:0050829; GO:0016045; GO:0006954; GO:0045087; GO:0046872; GO:0070269 ATP binding; IPAF inflammasome complex; apoptotic process; defense response to Gram-negative bacterium; detection of bacterium; inflammatory response; innate immune response; metal ion binding; pyroptosis IPR001370; IPR007111; IPR027417; Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5) Naip5 Birc1e Naip-rs3 Mus musculus (Mouse) TR35592_c0_g2_i3 Q9R016 BIR1E_MOUSE 7.00E-07 GO:0005524; GO:0072557; GO:0006915; GO:0050829; GO:0016045; GO:0006954; GO:0045087; GO:0046872; GO:0070269 ATP binding; IPAF inflammasome complex; apoptotic process; defense response to Gram-negative bacterium; detection of bacterium; inflammatory response; innate immune response; metal ion binding; pyroptosis IPR001370; IPR007111; IPR027417; Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5) Naip5 Birc1e Naip-rs3 Mus musculus (Mouse) TR35592_c0_g3_i1 Q9R0I6 XIAP_RAT 2.00E-08 GO:0016055; GO:0006915; GO:0005829; GO:0043524; GO:0005634; GO:0048471; GO:0043234; GO:0004842; GO:0008270 Wnt receptor signaling pathway; apoptotic process; cytosol; negative regulation of neuron apoptotic process; nucleus; perinuclear region of cytoplasm; protein complex; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (rIAP-3) (rIAP3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) Xiap Api3 Birc4 Rattus norvegicus (Rat) TR35593_c2_g3_i1 A1L314 MPEG1_MOUSE 8.00E-116 GO:0016021 integral to membrane IPR020864; Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) (Protein MPS1) Mpeg1 Mus musculus (Mouse) TR35594_c0_g1_i1 Q6GLE8 LRC28_XENTR 5.00E-43 IPR001611; IPR003591; Leucine-rich repeat-containing protein 28 lrrc28 TNeu055l03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35594_c0_g1_i2 Q7KRY7 LAP4_DROME 1.00E-16 GO:0072002; GO:0007464; GO:0030714; GO:0016327; GO:0016323; GO:0060581; GO:0001708; GO:0000902; GO:0007391; GO:0045198; GO:0001737; GO:0016332; GO:0016336; GO:0005576; GO:0045169; GO:0005179; GO:0016328; GO:0050680; GO:0045571; GO:0000122; GO:0031594; GO:0042048; GO:0007318; GO:0045823; GO:0046425; GO:0008593; GO:0051726; GO:0030100; GO:0042058; GO:0050803; GO:0007608; GO:0005918; GO:0019991; GO:0048863; GO:0072089; GO:0005923; GO:0045186 Q4AB30 "Malpighian tubule development; R3/R4 cell fate commitment; anterior/posterior axis specification, follicular epithelium; apicolateral plasma membrane; basolateral plasma membrane; cell fate commitment involved in pattern specification; cell fate specification; cell morphogenesis; dorsal closure; establishment of epithelial cell apical/basal polarity; establishment of imaginal disc-derived wing hair orientation; establishment or maintenance of polarity of embryonic epithelium; establishment or maintenance of polarity of larval imaginal disc epithelium; extracellular region; fusome; hormone activity; lateral plasma membrane; negative regulation of epithelial cell proliferation; negative regulation of imaginal disc growth; negative regulation of transcription from RNA polymerase II promoter; neuromuscular junction; olfactory behavior; pole plasm protein localization; positive regulation of heart contraction; regulation of JAK-STAT cascade; regulation of Notch signaling pathway; regulation of cell cycle; regulation of endocytosis; regulation of epidermal growth factor receptor signaling pathway; regulation of synapse structure and activity; sensory perception of smell; septate junction; septate junction assembly; stem cell differentiation; stem cell proliferation; tight junction; zonula adherens assembly" IPR001611; IPR025875; IPR001478; Protein lap4 (Protein scribble) (Protein smell-impaired) scrib smi vart CG5462 Drosophila melanogaster (Fruit fly) TR35594_c0_g1_i3 B3LWU3 SUR8_DROAN 4.00E-16 GO:0046579; GO:0000164 positive regulation of Ras protein signal transduction; protein phosphatase type 1 complex IPR001611; IPR025875; IPR003591; IPR027036; Leucine-rich repeat protein soc-2 homolog (Protein Sur-8 homolog) (Protein soc-2 homolog) Sur-8 GF16883 Drosophila ananassae (Fruit fly) TR35594_c0_g1_i4 Q9BTT6 LRRC1_HUMAN 4.00E-20 GO:0005737; GO:0016020 cytoplasm; membrane IPR001611; IPR025875; Leucine-rich repeat-containing protein 1 (LANO adapter protein) (LAP and no PDZ protein) LRRC1 LANO Homo sapiens (Human) TR35595_c1_g1_i1 Q6DBQ8 GLTD1_DANRE 2.00E-27 GO:0005794; GO:1902387; GO:1902389; GO:1902388; GO:0005829; GO:0010008; GO:0051861; GO:0046836; GO:0017089; GO:0005640; GO:0005886 Golgi apparatus; ceramide 1-phosphate binding; ceramide 1-phosphate transport; ceramide 1-phosphate transporter activity; cytosol; endosome membrane; glycolipid binding; glycolipid transport; glycolipid transporter activity; nuclear outer membrane; plasma membrane IPR014830; Ceramide-1-phosphate transfer protein (Glycolipid transfer protein domain-containing protein 1) (CPTP) gltpd1 zgc:92000 Danio rerio (Zebrafish) (Brachydanio rerio) TR35596_c1_g1_i1 P56839 PEPM_MYTED 0 GO:0046872; GO:0032923; GO:0050188 metal ion binding; organic phosphonate biosynthetic process; phosphoenolpyruvate mutase activity IPR012698; IPR015813; Phosphorus metabolism; phosphonate biosynthesis. Phosphoenolpyruvate phosphomutase (PEP mutase) (PEP phosphomutase) (Phosphoenolpyruvate mutase) (EC 5.4.2.9) Mytilus edulis (Blue mussel) TR35597_c5_g1_i1 Q9UFH2 DYH17_HUMAN 7.00E-51 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 17, axonemal (Axonemal beta dynein heavy chain 17) (Axonemal dynein heavy chain-like protein 1) (Ciliary dynein heavy chain 17) (Ciliary dynein heavy chain-like protein 1) (Dynein light chain 2, axonemal)" DNAH17 DNAHL1 DNEL2 Homo sapiens (Human) TR35599_c4_g2_i2 O54965 RNF13_MOUSE 1.00E-09 GO:0005829; GO:0016021; GO:0031902; GO:0005765; GO:0005637; GO:0051865; GO:0004842; GO:0008270 cytosol; integral to membrane; late endosome membrane; lysosomal membrane; nuclear inner membrane; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003137; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF13 (EC 6.3.2.-) (RING finger protein 13) Rnf13 Rzf Mus musculus (Mouse) TR35599_c5_g4_i1 Q0VCP9 CC149_BOVIN 2.00E-85 GO:0016021 integral to membrane IPR019179; Coiled-coil domain-containing protein 149 CCDC149 Bos taurus (Bovine) TR35599_c5_g4_i5 Q0VCP9 CC149_BOVIN 2.00E-82 GO:0016021 integral to membrane IPR019179; Coiled-coil domain-containing protein 149 CCDC149 Bos taurus (Bovine) TR35601_c0_g2_i5 P98087 CBLN2_RAT 3.00E-06 GO:0005615; GO:0051965 extracellular space; positive regulation of synapse assembly IPR001073; IPR008983; Cerebellin-2 (Cerebellin-like protein) Cbln2 Rattus norvegicus (Rat) TR35603_c0_g1_i1 Q5FWH7 S39AC_MOUSE 4.00E-51 GO:0016021; GO:0046873 integral to membrane; metal ion transmembrane transporter activity IPR003689; Zinc transporter ZIP12 (Solute carrier family 39 member 12) (Zrt- and Irt-like protein 12) (ZIP-12) Slc39a12 Zip12 Mus musculus (Mouse) TR35603_c0_g1_i2 Q5RAB7 S39AE_PONAB 1.00E-28 GO:0016021; GO:0046873; GO:0005886; GO:0071577 integral to membrane; metal ion transmembrane transporter activity; plasma membrane; zinc ion transmembrane transport IPR003689; Zinc transporter ZIP14 (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14) SLC39A14 ZIP14 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35603_c0_g1_i3 Q08E40 S39AC_BOVIN 6.00E-51 GO:0016021; GO:0046873; GO:0006829 integral to membrane; metal ion transmembrane transporter activity; zinc ion transport IPR003689; Zinc transporter ZIP12 (Solute carrier family 39 member 12) (Zrt- and Irt-like protein 12) (ZIP-12) SLC39A12 ZIP12 Bos taurus (Bovine) TR35603_c0_g1_i4 Q9VSL7 FOI_DROME 1.00E-33 GO:0035147; GO:0009986; GO:0007417; GO:0035262; GO:0007506; GO:0005887; GO:0022008; GO:0007280; GO:0005385 "branch fusion, open tracheal system; cell surface; central nervous system development; gonad morphogenesis; gonadal mesoderm development; integral to plasma membrane; neurogenesis; pole cell migration; zinc ion transmembrane transporter activity" IPR003689; Zinc transporter foi (Protein fear-of-intimacy) (Protein kastchen) foi CG6817 Drosophila melanogaster (Fruit fly) TR35603_c1_g2_i4 Q5FVQ0 S39A8_RAT 3.00E-35 GO:0016021; GO:0046873; GO:0031090; GO:0006829 integral to membrane; metal ion transmembrane transporter activity; organelle membrane; zinc ion transport IPR003689; Zinc transporter ZIP8 (Solute carrier family 39 member 8) (Zrt- and Irt-like protein 8) (ZIP-8) Slc39a8 Zip8 Rattus norvegicus (Rat) TR35604_c0_g1_i1 Q08214 NTG2_YEAST 1.00E-46 GO:0051539; GO:0006285; GO:0046872; GO:0005634; GO:0000703 "4 iron, 4 sulfur cluster binding; base-excision repair, AP site formation; metal ion binding; nucleus; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity" IPR011257; IPR004036; IPR003651; IPR003265; IPR023170; DNA base excision repair N-glycosylase 2 NTG2 YOL043C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR35604_c0_g1_i2 Q2KID2 NTHL1_BOVIN 2.00E-106 GO:0051539; GO:0019104; GO:0003906; GO:0006285; GO:0003690; GO:0046872; GO:0005739; GO:0006296; GO:0005634 "4 iron, 4 sulfur cluster binding; DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; base-excision repair, AP site formation; double-stranded DNA binding; metal ion binding; mitochondrion; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleus" IPR011257; IPR004036; IPR004035; IPR003651; IPR003265; IPR000445; IPR023170; Endonuclease III-like protein 1 (EC 4.2.99.18) NTHL1 Bos taurus (Bovine) TR35607_c0_g1_i2 P04066 FUCO_HUMAN 1.00E-166 GO:0004560; GO:0042806; GO:0006004; GO:0006027; GO:0005764 alpha-L-fucosidase activity; fucose binding; fucose metabolic process; glycosaminoglycan catabolic process; lysosome IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) FUCA1 Nbla10230 Homo sapiens (Human) TR35607_c0_g1_i3 Q9BTY2 FUCO2_HUMAN 1.00E-159 GO:0004560; GO:0005576; GO:0042806; GO:0006004; GO:0005764 alpha-L-fucosidase activity; extracellular region; fucose binding; fucose metabolic process; lysosome IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2) FUCA2 PSEC0151 UNQ227/PRO260 Homo sapiens (Human) TR35607_c0_g1_i4 Q9BTY2 FUCO2_HUMAN 2.00E-173 GO:0004560; GO:0005576; GO:0042806; GO:0006004; GO:0005764 alpha-L-fucosidase activity; extracellular region; fucose binding; fucose metabolic process; lysosome IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2) FUCA2 PSEC0151 UNQ227/PRO260 Homo sapiens (Human) TR35607_c0_g2_i1 C3YWU0 FUCO_BRAFL 3.00E-175 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR35607_c0_g2_i4 P04066 FUCO_HUMAN 7.00E-162 GO:0004560; GO:0042806; GO:0006004; GO:0006027; GO:0005764 alpha-L-fucosidase activity; fucose binding; fucose metabolic process; glycosaminoglycan catabolic process; lysosome IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) FUCA1 Nbla10230 Homo sapiens (Human) TR35607_c0_g2_i6 Q8GW72 FUCO1_ARATH 3.00E-06 GO:0004560; GO:0048046; GO:0005975; GO:0006516; GO:0005773 Q9ZPS9 alpha-L-fucosidase activity; apoplast; carbohydrate metabolic process; glycoprotein catabolic process; vacuole IPR008979; IPR000933; IPR013781; IPR017853; "Alpha-L-fucosidase 1 (EC 3.2.1.51) (Alpha-1,3/4-fucosidase) (AtFUC1) (Alpha-L-fucoside fucohydrolase)" FUC1 At2g28100 F24D13.11 Arabidopsis thaliana (Mouse-ear cress) TR35610_c2_g1_i1 Q6GLQ4 PP1RA_XENLA 1.00E-40 GO:0003677; GO:0046872; GO:0005634; GO:0004864; GO:0006351 "DNA binding; metal ion binding; nucleus; protein phosphatase inhibitor activity; transcription, DNA-dependent" IPR017923; IPR000571; Serine/threonine-protein phosphatase 1 regulatory subunit 10 ppp1r10 Xenopus laevis (African clawed frog) TR35611_c2_g1_i1 Q7SXA9 MUS81_DANRE 8.00E-07 GO:0003677; GO:0006310; GO:0006281; GO:0004519; GO:0046872; GO:0090305; GO:0005634 DNA binding; DNA recombination; DNA repair; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleus IPR010996; IPR020819; IPR006166; IPR003583; IPR027420; IPR011335; Crossover junction endonuclease MUS81 (EC 3.1.22.-) mus81 Danio rerio (Zebrafish) (Brachydanio rerio) TR35613_c2_g1_i3 O76387 PTH2_CAEEL 1.00E-28 GO:0004045 aminoacyl-tRNA hydrolase activity IPR023476; IPR002833; IPR009060; IPR015940; IPR000449; Probable peptidyl-tRNA hydrolase 2 (PTH 2) (EC 3.1.1.29) C24G6.8 Caenorhabditis elegans TR35614_c4_g2_i4 Q9H497 TOR3A_HUMAN 7.00E-38 GO:0005524; GO:0051085; GO:0005788 ATP binding; chaperone mediated protein folding requiring cofactor; endoplasmic reticulum lumen IPR027417; IPR010448; Torsin-3A (ATP-dependent interferon-responsive protein) (Torsin family 3 member A) TOR3A ADIR Homo sapiens (Human) TR35614_c4_g2_i5 O14657 TOR1B_HUMAN 7.00E-65 GO:0005524; GO:0051085; GO:0005788; GO:0005635; GO:0071763; GO:0017111; GO:0051260; GO:0006986; GO:0051082 ATP binding; chaperone mediated protein folding requiring cofactor; endoplasmic reticulum lumen; nuclear envelope; nuclear membrane organization; nucleoside-triphosphatase activity; protein homooligomerization; response to unfolded protein; unfolded protein binding IPR003593; IPR027417; IPR010448; IPR017378; Torsin-1B (Torsin family 1 member B) TOR1B DQ1 FKSG18 Homo sapiens (Human) TR35616_c0_g1_i1 Q0VD42 TM136_BOVIN 5.00E-59 GO:0016021 integral to membrane IPR006634; Transmembrane protein 136 TMEM136 Bos taurus (Bovine) TR35617_c0_g3_i1 Q9YH95 PAX5_XENLA 1.00E-78 GO:0003677; GO:0007275; GO:0005634; GO:0003700; GO:0006351 "DNA binding; multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR009057; IPR001523; IPR022130; IPR011991; Paired box protein Pax-5 (XPax-5) pax5 pax-5 Xenopus laevis (African clawed frog) TR35617_c0_g3_i2 Q90268 PAX2A_DANRE 7.00E-79 GO:0003677; GO:0001708; GO:0021588; GO:0048596; GO:0009880; GO:0060113; GO:0030901; GO:0030917; GO:0005634; GO:0043049; GO:0007422; GO:0035775; GO:0072114; GO:0003700; GO:0030878; GO:0006351 "DNA binding; cell fate specification; cerebellum formation; embryonic camera-type eye morphogenesis; embryonic pattern specification; inner ear receptor cell differentiation; midbrain development; midbrain-hindbrain boundary development; nucleus; otic placode formation; peripheral nervous system development; pronephric glomerulus morphogenesis; pronephros morphogenesis; sequence-specific DNA binding transcription factor activity; thyroid gland development; transcription, DNA-dependent" IPR009057; IPR001523; IPR022130; IPR011991; Paired box protein Pax-2a (No isthmus protein) (Pax[Zf-b]) pax2a noi pax2.1 paxzf-b Danio rerio (Zebrafish) (Brachydanio rerio) TR35622_c2_g1_i1 Q3T000 YKT6_BOVIN 2.00E-13 GO:0006888; GO:0000139; GO:0030659; GO:0005829; GO:0005783; GO:0005768; GO:0005887; GO:0005739; GO:0015031; GO:0019706; GO:0042147; GO:0006904; GO:0006903 "ER to Golgi vesicle-mediated transport; Golgi membrane; cytoplasmic vesicle membrane; cytosol; endoplasmic reticulum; endosome; integral to plasma membrane; mitochondrion; protein transport; protein-cysteine S-palmitoyltransferase activity; retrograde transport, endosome to Golgi; vesicle docking involved in exocytosis; vesicle targeting" IPR011012; IPR010908; IPR001388; Synaptobrevin homolog YKT6 (EC 2.3.1.-) YKT6 Bos taurus (Bovine) TR35622_c2_g1_i2 Q9CQW1 YKT6_MOUSE 8.00E-73 GO:0006888; GO:0000139; GO:0031201; GO:0030659; GO:0005829; GO:0005783; GO:0005768; GO:0005887; GO:0005739; GO:0015031; GO:0019706; GO:0042147; GO:0006904; GO:0006903 "ER to Golgi vesicle-mediated transport; Golgi membrane; SNARE complex; cytoplasmic vesicle membrane; cytosol; endoplasmic reticulum; endosome; integral to plasma membrane; mitochondrion; protein transport; protein-cysteine S-palmitoyltransferase activity; retrograde transport, endosome to Golgi; vesicle docking involved in exocytosis; vesicle targeting" IPR011012; IPR010908; IPR001388; Synaptobrevin homolog YKT6 (EC 2.3.1.-) Ykt6 Mus musculus (Mouse) TR35623_c2_g1_i1 Q5DU00 DCDC2_MOUSE 8.00E-16 GO:0048813; GO:0035556; GO:0001764; GO:0008542 dendrite morphogenesis; intracellular signal transduction; neuron migration; visual learning IPR003533; Doublecortin domain-containing protein 2 Dcdc2 Dcdc2a Kiaa1154 Mus musculus (Mouse) TR35624_c8_g1_i1 Q2EMV9 PAR14_MOUSE 2.00E-42 GO:0003950; GO:0005737; GO:0003676; GO:0005634; GO:0005886; GO:0006355; GO:0006351 P06745 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleic acid binding; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR000504; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) TR35624_c8_g1_i2 Q9WYX8 Y508_THEMA 9.00E-25 GO:0005524; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0009378 ATP binding; DNA binding; DNA recombination; DNA repair; DNA replication; four-way junction helicase activity IPR003593; IPR008824; IPR008921; IPR002589; IPR021886; IPR027417; Uncharacterized protein TM_0508 TM_0508 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR35624_c8_g1_i4 Q2EMV9 PAR14_MOUSE 2.00E-44 GO:0003950; GO:0005737; GO:0003676; GO:0005634; GO:0005886; GO:0006355; GO:0006351 P06745 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleic acid binding; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR000504; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) TR35624_c8_g1_i5 Q8RHQ2 Y1951_FUSNN 2.00E-13 IPR002589; Uncharacterized protein FN1951 FN1951 Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131) TR35625_c0_g3_i1 Q01538 MYT1_HUMAN 5.00E-06 GO:0003677; GO:0030154; GO:0007399; GO:0005634; GO:0003700; GO:0006351; GO:0008270 "DNA binding; cell differentiation; nervous system development; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR013681; IPR002515; Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) MYT1 KIAA0835 KIAA1050 MTF1 MYTI PLPB1 Homo sapiens (Human) TR35625_c1_g2_i2 Q7SYR1 OSGEP_XENLA 0 GO:0046872; GO:0008033 metal ion binding; tRNA processing IPR000905; IPR017861; IPR017860; Probable tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.-) (O-sialoglycoprotein endopeptidase) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgep) (tRNA threonylcarbamoyladenosine biosynthesis protein osgep) osgep Xenopus laevis (African clawed frog) TR35625_c1_g2_i3 Q92794 KAT6A_HUMAN 1.00E-71 GO:0003677; GO:0006323; GO:0070776; GO:0016605; GO:0035909; GO:0090398; GO:0003682; GO:0035162; GO:0060325; GO:0003007; GO:0043966; GO:0004402; GO:0030099; GO:0043433; GO:0045892; GO:0005730; GO:0000786; GO:0006334; GO:0045893; GO:0035019; GO:0003713; GO:0008134; GO:0006351; GO:0008270 Q03164; P61964 "DNA binding; DNA packaging; MOZ/MORF histone acetyltransferase complex; PML body; aorta morphogenesis; cellular senescence; chromatin binding; embryonic hemopoiesis; face morphogenesis; heart morphogenesis; histone H3 acetylation; histone acetyltransferase activity; myeloid cell differentiation; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription, DNA-dependent; nucleolus; nucleosome; nucleosome assembly; positive regulation of transcription, DNA-dependent; somatic stem cell maintenance; transcription coactivator activity; transcription factor binding; transcription, DNA-dependent; zinc ion binding" IPR016181; IPR005818; IPR002717; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; "Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220)" KAT6A MOZ MYST3 RUNXBP2 ZNF220 Homo sapiens (Human) TR35625_c1_g2_i4 Q7SYR1 OSGEP_XENLA 3.00E-179 GO:0046872; GO:0008033 metal ion binding; tRNA processing IPR000905; IPR017861; IPR017860; Probable tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.-) (O-sialoglycoprotein endopeptidase) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgep) (tRNA threonylcarbamoyladenosine biosynthesis protein osgep) osgep Xenopus laevis (African clawed frog) TR35628_c6_g1_i2 P18173 DHGL_DROME 5.00E-114 GO:0006066; GO:0008812; GO:0005576; GO:0050660; GO:0004344; GO:0006006; GO:0008364; GO:0046693 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding; glucose dehydrogenase activity; glucose metabolic process; pupal chitin-based cuticle development; sperm storage IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld CG1152 Drosophila melanogaster (Fruit fly) TR35628_c6_g2_i1 B4SHV9 BETA_STRM5 8.00E-10 GO:0008802; GO:0008812; GO:0050660; GO:0019285 betaine-aldehyde dehydrogenase activity; choline dehydrogenase activity; flavin adenine dinucleotide binding; glycine betaine biosynthetic process from choline IPR011533; IPR012132; IPR000172; IPR007867; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. Oxygen-dependent choline dehydrogenase (CDH) (CHD) (EC 1.1.99.1) (Betaine aldehyde dehydrogenase) (BADH) (EC 1.2.1.8) betA Smal_1832 Stenotrophomonas maltophilia (strain R551-3) TR35631_c0_g1_i1 Q5SWK7 RN145_MOUSE 4.00E-06 GO:0016021; GO:0008270 integral to membrane; zinc ion binding IPR025754; IPR001841; IPR013083; RING finger protein 145 Rnf145 Mus musculus (Mouse) TR35631_c0_g2_i1 Q9UKV5 AMFR_HUMAN 4.00E-115 GO:0030433; GO:0006928; GO:0030968; GO:0030176; GO:0051259; GO:0000209; GO:0004872; GO:0004842; GO:0008270 P55072 ER-associated protein catabolic process; cellular component movement; endoplasmic reticulum unfolded protein response; integral to endoplasmic reticulum membrane; protein oligomerization; protein polyubiquitination; receptor activity; ubiquitin-protein ligase activity; zinc ion binding IPR026608; IPR003892; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase AMFR (EC 6.3.2.-) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78) AMFR RNF45 Homo sapiens (Human) TR35632_c2_g1_i1 Q0V9S9 CC135_XENTR 9.00E-123 GO:0030154; GO:0001539; GO:0005929; GO:0007283 cell differentiation; ciliary or bacterial-type flagellar motility; cilium; spermatogenesis Coiled-coil domain-containing protein lobo homolog (Coiled-coil domain-containing protein 135) ccdc135 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35632_c2_g1_i2 Q8IY82 CC135_HUMAN 8.00E-119 GO:0030154; GO:0001539; GO:0005929; GO:0005737; GO:0007283 cell differentiation; ciliary or bacterial-type flagellar motility; cilium; cytoplasm; spermatogenesis Coiled-coil domain-containing protein lobo homolog (Coiled-coil domain-containing protein 135) CCDC135 C16orf50 Homo sapiens (Human) TR35632_c2_g2_i1 Q2T9M4 CC135_BOVIN 4.00E-20 GO:0030154; GO:0001539; GO:0005929; GO:0005737; GO:0007283 cell differentiation; ciliary or bacterial-type flagellar motility; cilium; cytoplasm; spermatogenesis Coiled-coil domain-containing protein lobo homolog (Coiled-coil domain-containing protein 135) CCDC135 Bos taurus (Bovine) TR35634_c4_g2_i1 Q9D2F7 P210L_MOUSE 5.00E-20 GO:0060009; GO:0016021; GO:0007286 Sertoli cell development; integral to membrane; spermatid development IPR003343; IPR008964; Nuclear pore membrane glycoprotein 210-like (Nucleoporin 210 kDa-like) (Nucleoporin Nup210-like) Nup210l Mus musculus (Mouse) TR35634_c6_g1_i1 O60494 CUBN_HUMAN 5.00E-08 GO:0005794; GO:0016324; GO:0031526; GO:0005509; GO:0008203; GO:0005905; GO:0031419; GO:0009235; GO:0015889; GO:0005829; GO:0030139; GO:0005783; GO:0010008; GO:0031232; GO:0042157; GO:0042953; GO:0043202; GO:0005765; GO:0042803; GO:0004872; GO:0006898; GO:0001894; GO:0005215; GO:0042359 Golgi apparatus; apical plasma membrane; brush border membrane; calcium ion binding; cholesterol metabolic process; coated pit; cobalamin binding; cobalamin metabolic process; cobalamin transport; cytosol; endocytic vesicle; endoplasmic reticulum; endosome membrane; extrinsic to external side of plasma membrane; lipoprotein metabolic process; lipoprotein transport; lysosomal lumen; lysosomal membrane; protein homodimerization activity; receptor activity; receptor-mediated endocytosis; tissue homeostasis; transporter activity; vitamin D metabolic process IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR009030; Cubilin (460 kDa receptor) (Intestinal intrinsic factor receptor) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) CUBN IFCR Homo sapiens (Human) TR35634_c6_g1_i2 Q0IIH7 ST14_BOVIN 2.00E-12 GO:0016021; GO:0006508; GO:0004252 integral to membrane; proteolysis; serine-type endopeptidase activity IPR000859; IPR023415; IPR002172; IPR001254; IPR018114; IPR017051; IPR000082; IPR009003; Suppressor of tumorigenicity 14 protein homolog (EC 3.4.21.109) (Serine protease 14) ST14 PRSS14 Bos taurus (Bovine) TR35635_c0_g1_i1 Q13426 XRCC4_HUMAN 4.00E-22 GO:0032807; GO:0051103; GO:0005958; GO:0033077; GO:0071285; GO:0007417; GO:0005829; GO:0006303; GO:0075713; GO:0033152; GO:0001701; GO:0045190; GO:0043524; GO:0005654; GO:0048146; GO:0051351; GO:0050769; GO:0002328; GO:0010165; GO:0010332 Q8IW19; Q7Z2E3; O00499; Q9H9Q4; Q96T60 DNA ligase IV complex; DNA ligation involved in DNA repair; DNA-dependent protein kinase-DNA ligase 4 complex; T cell differentiation in thymus; cellular response to lithium ion; central nervous system development; cytosol; double-strand break repair via nonhomologous end joining; establishment of integrated proviral latency; immunoglobulin V(D)J recombination; in utero embryonic development; isotype switching; negative regulation of neuron apoptotic process; nucleoplasm; positive regulation of fibroblast proliferation; positive regulation of ligase activity; positive regulation of neurogenesis; pro-B cell differentiation; response to X-ray; response to gamma radiation IPR010585; IPR014751; IPR009089; DNA repair protein XRCC4 (X-ray repair cross-complementing protein 4) XRCC4 Homo sapiens (Human) TR35636_c0_g2_i3 Q55BZ4 PCY2_DICDI 1.00E-26 GO:0004306; GO:0045335; GO:0006646 ethanolamine-phosphate cytidylyltransferase activity; phagocytic vesicle; phosphatidylethanolamine biosynthetic process IPR004821; IPR014729; Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3. Ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase) pctA DDB_G0270298 Dictyostelium discoideum (Slime mold) TR35636_c0_g2_i4 Q9Y5K3 PCY1B_HUMAN 3.00E-101 GO:0004105; GO:0005789; GO:0001541; GO:0007283 choline-phosphate cytidylyltransferase activity; endoplasmic reticulum membrane; ovarian follicle development; spermatogenesis IPR004821; IPR014729; Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2. Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) PCYT1B CCTB Homo sapiens (Human) TR35638_c1_g1_i1 P70031 CCKAR_XENLA 1.00E-07 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR009126; IPR000276; IPR017452; Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) TR35638_c1_g1_i2 Q7YW31 CTR1_OCTVU 9.00E-08 GO:0016021; GO:0005886; GO:0016500; GO:0005000 integral to membrane; plasma membrane; protein-hormone receptor activity; vasopressin receptor activity IPR000276; IPR017452; IPR001817; Cephalotocin receptor 1 (OC/CE-R 1) (OT/VP superfamily peptide receptor 1) CTR1 Octopus vulgaris (Common octopus) TR35639_c3_g1_i1 Q87040 POL_SFVCP 2.00E-06 GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0075713; GO:0030430; GO:0042025; GO:0046872; GO:0090305; GO:0006508; GO:0004523; GO:0046718; GO:0075732; GO:0019012 DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; establishment of integrated proviral latency; host cell cytoplasm; host cell nucleus; metal ion binding; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; viral entry into host cell; viral penetration into host nucleus; virion IPR001584; IPR012337; IPR002156; IPR000477; IPR001641; Pro-Pol polyprotein (Pr125Pol) [Cleaved into: Protease/Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (EC 3.4.23.-) (p87Pro-RT-RNaseH); Protease/Reverse transcriptase (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.4.23.-) (p65Pro-RT); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN) (p42In)] pol Simian foamy virus (isolate chimpanzee) (SFVcpz) TR35640_c0_g1_i2 Q7ZYB4 PAIP1_XENLA 8.00E-34 GO:0003723; GO:0005737; GO:0008494 RNA binding; cytoplasm; translation activator activity IPR016024; IPR016021; IPR003890; Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Paip1 protein) (Poly(A)-binding protein-interacting protein 1) (XlPaip1) paip1 Xenopus laevis (African clawed frog) TR35641_c4_g1_i3 Q5BKL8 XIAP_XENTR 2.00E-10 GO:0016055; GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0045861; GO:0008270 Wnt receptor signaling pathway; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; negative regulation of proteolysis; zinc ion binding IPR001370; IPR001841; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (X-linked inhibitor of apoptosis protein) (X-linked IAP) xiap birc4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35641_c4_g2_i1 Q24307 IAP2_DROME 2.00E-39 GO:0050829; GO:0043066; GO:0043154; GO:0061057; GO:0006964; GO:0033160; GO:0070534; GO:0007423; GO:0008270 "defense response to Gram-negative bacterium; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; peptidoglycan recognition protein signaling pathway; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; positive regulation of protein import into nucleus, translocation; protein K63-linked ubiquitination; sensory organ development; zinc ion binding" IPR001370; IPR001841; IPR013083; Apoptosis 2 inhibitor (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) (dIAP2) Iap2 DIHA ILP CG8293 Drosophila melanogaster (Fruit fly) TR35643_c1_g1_i1 Q61263 SOAT1_MOUSE 1.00E-149 GO:0034736; GO:0015485; GO:0033344; GO:0034435; GO:0008203; GO:0010878; GO:0005789; GO:0000062; GO:0016021; GO:0010742; GO:0042986; GO:0004772; GO:0034379 cholesterol O-acyltransferase activity; cholesterol binding; cholesterol efflux; cholesterol esterification; cholesterol metabolic process; cholesterol storage; endoplasmic reticulum membrane; fatty-acyl-CoA binding; integral to membrane; macrophage derived foam cell differentiation; positive regulation of amyloid precursor protein biosynthetic process; sterol O-acyltransferase activity; very-low-density lipoprotein particle assembly IPR004299; IPR014371; Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) Soat1 Acact Mus musculus (Mouse) TR35643_c1_g1_i2 Q60457 SOAT1_CRIGR 3.00E-148 GO:0034736; GO:0008203; GO:0005789; GO:0016021 cholesterol O-acyltransferase activity; cholesterol metabolic process; endoplasmic reticulum membrane; integral to membrane IPR004299; IPR014371; Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) SOAT1 ACAT ACAT1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR35643_c1_g1_i3 Q61263 SOAT1_MOUSE 2.00E-148 GO:0034736; GO:0015485; GO:0033344; GO:0034435; GO:0008203; GO:0010878; GO:0005789; GO:0000062; GO:0016021; GO:0010742; GO:0042986; GO:0004772; GO:0034379 cholesterol O-acyltransferase activity; cholesterol binding; cholesterol efflux; cholesterol esterification; cholesterol metabolic process; cholesterol storage; endoplasmic reticulum membrane; fatty-acyl-CoA binding; integral to membrane; macrophage derived foam cell differentiation; positive regulation of amyloid precursor protein biosynthetic process; sterol O-acyltransferase activity; very-low-density lipoprotein particle assembly IPR004299; IPR014371; Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) Soat1 Acact Mus musculus (Mouse) TR35645_c2_g1_i1 Q9BTT6 LRRC1_HUMAN 1.00E-20 GO:0005737; GO:0016020 cytoplasm; membrane IPR001611; IPR025875; Leucine-rich repeat-containing protein 1 (LANO adapter protein) (LAP and no PDZ protein) LRRC1 LANO Homo sapiens (Human) TR35645_c3_g2_i4 O13432 SYFB_CANAX 5.00E-20 GO:0005524; GO:0003723; GO:0005737; GO:0000287; GO:0004826; GO:0006432 ATP binding; RNA binding; cytoplasm; magnesium ion binding; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation IPR005146; IPR009061; IPR004531; IPR005147; Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS) FRS1 Ca49C4.04c Candida albicans (Yeast) TR35645_c3_g2_i5 Q505F5 LRC47_MOUSE 5.00E-72 GO:0003723; GO:0004826 RNA binding; phenylalanine-tRNA ligase activity IPR005146; IPR001611; IPR025875; IPR003591; Leucine-rich repeat-containing protein 47 Lrrc47 Kiaa1185 Mus musculus (Mouse) TR35646_c3_g1_i1 A8DZE7 D42E1_DANRE 2.00E-139 GO:0003854; GO:0016021; GO:0006694 3-beta-hydroxy-delta5-steroid dehydrogenase activity; integral to membrane; steroid biosynthetic process IPR002225; IPR016040; Short-chain dehydrogenase/reductase family 42E member 1 (EC 1.1.1.-) sdr42e1 si:ch211-79l17.4 zgc:123280 Danio rerio (Zebrafish) (Brachydanio rerio) TR35646_c3_g1_i2 Q4R7R1 D42E1_MACFA 1.00E-141 GO:0003854; GO:0016021; GO:0006694 3-beta-hydroxy-delta5-steroid dehydrogenase activity; integral to membrane; steroid biosynthetic process IPR002225; IPR016040; Short-chain dehydrogenase/reductase family 42E member 1 (EC 1.1.1.-) SDR42E1 QtsA-14586 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR35650_c0_g1_i1 Q96N87 S6A18_HUMAN 5.00E-126 GO:0006865; GO:0005887; GO:0005328; GO:0005886; GO:0055085 amino acid transport; integral to plasma membrane; neurotransmitter:sodium symporter activity; plasma membrane; transmembrane transport IPR000175; IPR002438; Sodium-dependent neutral amino acid transporter B(0)AT3 (Sodium- and chloride-dependent transporter XTRP2) (Solute carrier family 6 member 18) (System B(0) neutral amino acid transporter AT3) SLC6A18 XTRP2 Homo sapiens (Human) TR35651_c0_g1_i2 Q9NXK8 FXL12_HUMAN 6.00E-07 GO:0005737; GO:0016567; GO:0000151; GO:0006511 P49918; Q9H0A6 cytoplasm; protein ubiquitination; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process IPR001810; Protein modification; protein ubiquitination. F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12) FBXL12 FBL12 Homo sapiens (Human) TR35651_c0_g2_i1 Q8BH16 FBXL2_MOUSE 3.00E-06 GO:0016020; GO:0006513; GO:0006511; GO:0004842 membrane; protein monoubiquitination; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR001810; IPR006553; F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) Fbxl2 Fbl2 Mus musculus (Mouse) TR35652_c3_g2_i1 Q5ZJ75 SL9A8_CHICK 1.00E-85 GO:0000139; GO:0016021; GO:0006885; GO:0015385 Golgi membrane; integral to membrane; regulation of pH; sodium:hydrogen antiporter activity IPR006153; IPR018422; IPR018409; IPR004709; Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8) Gallus gallus (Chicken) TR35652_c9_g3_i1 Q9Y2E8 SL9A8_HUMAN 3.00E-60 GO:0000139; GO:0016021; GO:0006811; GO:0015386; GO:0051453; GO:0015385; GO:0055085 Golgi membrane; integral to membrane; ion transport; potassium:hydrogen antiporter activity; regulation of intracellular pH; sodium:hydrogen antiporter activity; transmembrane transport IPR006153; IPR018422; IPR018409; IPR004709; Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8) SLC9A8 KIAA0939 NHE8 Homo sapiens (Human) TR35653_c0_g1_i3 Q9UHV9 PFD2_HUMAN 1.00E-39 GO:0051084; GO:0005739; GO:0005634; GO:0016272; GO:0051082 'de novo' posttranslational protein folding; mitochondrion; nucleus; prefoldin complex; unfolded protein binding IPR027235; IPR002777; IPR009053; Prefoldin subunit 2 PFDN2 PFD2 HSPC231 Homo sapiens (Human) TR35654_c0_g1_i1 Q95ZQ4 AAPK2_CAEEL 6.00E-42 GO:0004679; GO:0005524; GO:0030424; GO:0005737; GO:0008340; GO:0043025; GO:0018105; GO:0061066; GO:0006950 Q9NAH7 AMP-activated protein kinase activity; ATP binding; axon; cytoplasm; determination of adult lifespan; neuronal cell body; peptidyl-serine phosphorylation; positive regulation of dauer larval development; response to stress IPR028375; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) aak-2 T01C8.1 Caenorhabditis elegans TR35654_c0_g1_i2 O54863 TSSK2_MOUSE 2.00E-73 GO:0005524; GO:0001669; GO:0005814; GO:0000287; GO:0007275; GO:0046777; GO:0004674; GO:0007286 ATP binding; acrosomal vesicle; centriole; magnesium ion binding; multicellular organismal development; protein autophosphorylation; protein serine/threonine kinase activity; spermatid development IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (Serine/threonine-protein kinase 22B) Tssk2 Stk22b Mus musculus (Mouse) TR35654_c0_g1_i3 O54863 TSSK2_MOUSE 9.00E-74 GO:0005524; GO:0001669; GO:0005814; GO:0000287; GO:0007275; GO:0046777; GO:0004674; GO:0007286 ATP binding; acrosomal vesicle; centriole; magnesium ion binding; multicellular organismal development; protein autophosphorylation; protein serine/threonine kinase activity; spermatid development IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (Serine/threonine-protein kinase 22B) Tssk2 Stk22b Mus musculus (Mouse) TR35655_c1_g1_i1 Q9VIW7 RTCB_DROME 0 GO:0005524; GO:0003972; GO:0046872; GO:0022008; GO:0006388; GO:0072669 Q9V4C9 "ATP binding; RNA ligase (ATP) activity; metal ion binding; neurogenesis; tRNA splicing, via endonucleolytic cleavage and ligation; tRNA-splicing ligase complex" IPR001233; IPR027513; tRNA-splicing ligase RtcB homolog (EC 6.5.1.3) CG9987 Drosophila melanogaster (Fruit fly) TR35655_c1_g1_i3 Q5E9T9 RTCB_BOVIN 0 GO:0005524; GO:0003972; GO:0005737; GO:0001701; GO:0046872; GO:0001890; GO:0006388; GO:0072669 "ATP binding; RNA ligase (ATP) activity; cytoplasm; in utero embryonic development; metal ion binding; placenta development; tRNA splicing, via endonucleolytic cleavage and ligation; tRNA-splicing ligase complex" IPR001233; IPR027513; tRNA-splicing ligase RtcB homolog (EC 6.5.1.3) RTCB Bos taurus (Bovine) TR35656_c2_g1_i3 Q9ZUC1 QORL_ARATH 1.00E-10 GO:0035798; GO:0048046; GO:0009941; GO:0009570; GO:0035671; GO:0009409; GO:0010319; GO:0009579; GO:0008270 2-alkenal reductase (NADP+) activity; apoplast; chloroplast envelope; chloroplast stroma; enone reductase activity; response to cold; stromule; thylakoid; zinc ion binding IPR013154; IPR002085; IPR011032; IPR016040; IPR002364; "Quinone oxidoreductase-like protein At1g23740, chloroplastic (EC 1.-.-.-)" At1g23740 F5O8.29 Arabidopsis thaliana (Mouse-ear cress) TR35656_c2_g1_i4 B0BNC9 QORL2_RAT 2.00E-81 GO:0005739; GO:0016491; GO:0008270 mitochondrion; oxidoreductase activity; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; Quinone oxidoreductase-like protein 2 (EC 1.-.-.-) Rattus norvegicus (Rat) TR35656_c3_g1_i3 Q7SY07 EIF1A_DANRE 2.00E-42 GO:0005634; GO:0003743 nucleus; translation initiation factor activity IPR012340; IPR006196; Probable RNA-binding protein EIF1AD (Eukaryotic translation initiation factor 1A domain-containing protein) eif1ad zgc:63631 Danio rerio (Zebrafish) (Brachydanio rerio) TR35656_c3_g1_i4 Q7SY07 EIF1A_DANRE 2.00E-42 GO:0005634; GO:0003743 nucleus; translation initiation factor activity IPR012340; IPR006196; Probable RNA-binding protein EIF1AD (Eukaryotic translation initiation factor 1A domain-containing protein) eif1ad zgc:63631 Danio rerio (Zebrafish) (Brachydanio rerio) TR35657_c0_g1_i1 Q00537 CDK17_HUMAN 0 GO:0005524; GO:0004693; GO:0004672 P63104 ATP binding; cyclin-dependent protein serine/threonine kinase activity; protein kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2) CDK17 PCTAIRE2 PCTK2 Homo sapiens (Human) TR35657_c0_g1_i3 Q00536 CDK16_HUMAN 0 GO:0005524; GO:0030054; GO:0004693; GO:0005737; GO:0006887; GO:0031234; GO:0030252; GO:0043005; GO:0031175; GO:0004674; GO:0061178; GO:0007283; GO:0008021; GO:0030133 Q15436 ATP binding; cell junction; cyclin-dependent protein serine/threonine kinase activity; cytoplasm; exocytosis; extrinsic to internal side of plasma membrane; growth hormone secretion; neuron projection; neuron projection development; protein serine/threonine kinase activity; regulation of insulin secretion involved in cellular response to glucose stimulus; spermatogenesis; synaptic vesicle; transport vesicle IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) CDK16 PCTAIRE1 PCTK1 Homo sapiens (Human) TR35658_c0_g1_i1 Q92747 ARC1A_HUMAN 7.00E-172 GO:0038096; GO:0003779; GO:0015629; GO:0030036; GO:0005829; GO:0045087; GO:0030833 Fc-gamma receptor signaling pathway involved in phagocytosis; actin binding; actin cytoskeleton; actin cytoskeleton organization; cytosol; innate immune response; regulation of actin filament polymerization IPR017383; IPR015943; IPR001680; IPR017986; Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) ARPC1A SOP2L Homo sapiens (Human) TR35659_c0_g1_i1 Q68CQ4 DIEXF_HUMAN 0 GO:0007275; GO:0005730 multicellular organismal development; nucleolus IPR010678; IPR027417; Digestive organ expansion factor homolog DIEXF C1orf107 DEF Homo sapiens (Human) TR35661_c1_g1_i1 Q7RXR3 CENPA_NEUCR 9.00E-38 GO:0003677; GO:0000777; GO:0000786; GO:0006334; GO:0005634 DNA binding; condensed chromosome kinetochore; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR000164; Histone H3-like centromeric protein cse-4 (CENP-A homolog) cse-4 hHv3 NCU00145 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR35662_c0_g2_i1 P60517 GBRAP_RAT 4.00E-68 GO:0000139; GO:0015629; GO:0005776; GO:0000421; GO:0006914; GO:0044297; GO:0031410; GO:0008625; GO:0005764; GO:0005874; GO:0005875; GO:0000226; GO:0048471; GO:0005886; GO:0015031; GO:0005790 Golgi membrane; actin cytoskeleton; autophagic vacuole; autophagic vacuole membrane; autophagy; cell body; cytoplasmic vesicle; extrinsic apoptotic signaling pathway via death domain receptors; lysosome; microtubule; microtubule associated complex; microtubule cytoskeleton organization; perinuclear region of cytoplasm; plasma membrane; protein transport; smooth endoplasmic reticulum IPR004241; Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) Gabarap Rattus norvegicus (Rat) TR35663_c1_g1_i1 Q12829 RB40B_HUMAN 2.00E-121 GO:0005525; GO:0005886; GO:0015031; GO:0016567; GO:0007264 GTP binding; plasma membrane; protein transport; protein ubiquitination; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; IPR001496; Protein modification; protein ubiquitination. Ras-related protein Rab-40B (SOCS box-containing protein RAR) (Protein Rar) RAB40B SEC4L Homo sapiens (Human) TR35664_c2_g1_i1 Q9D2Y9 ELOV7_MOUSE 5.00E-12 GO:0005783; GO:0005789; GO:0034626; GO:0019367; GO:0016021; GO:0016740; GO:0042761 "endoplasmic reticulum; endoplasmic reticulum membrane; fatty acid elongation, polyunsaturated fatty acid; fatty acid elongation, saturated fatty acid; integral to membrane; transferase activity; very long-chain fatty acid biosynthetic process" IPR002076; Elongation of very long chain fatty acids protein 7 (EC 2.3.1.199) (3-keto acyl-CoA synthase Elovl7) (ELOVL fatty acid elongase 7) (ELOVL FA elongase 7) (Very-long-chain 3-oxoacyl-CoA synthase 7) Elovl7 Mus musculus (Mouse) TR35665_c2_g1_i1 Q9UAS2 FABP1_FASGI 6.00E-06 GO:0008289; GO:0005215 lipid binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; Fatty acid-binding protein 1 FABP-1 Fasciola gigantica (Giant liver fluke) TR35665_c3_g1_i4 Q15696 U2AFM_HUMAN 1.00E-29 GO:0005689; GO:0046872; GO:0000166; GO:0030628; GO:0000245 U12-type spliceosomal complex; metal ion binding; nucleotide binding; pre-mRNA 3'-splice site binding; spliceosomal complex assembly IPR012677; IPR000504; IPR009145; IPR000571; "U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (U2AF35-related protein) (URP)" ZRSR2 U2AF1-RS2 U2AF1L2 U2AF1RS2 URP Homo sapiens (Human) TR35665_c4_g1_i2 Q9VEC1 MED17_DROME 7.00E-167 GO:0001104; GO:0005694; GO:0016592; GO:0007095; GO:0045944; GO:0045498 P91641; Q8MSX2 RNA polymerase II transcription cofactor activity; chromosome; mediator complex; mitotic G2 DNA damage checkpoint; positive regulation of transcription from RNA polymerase II promoter; sex comb development IPR019313; Mediator of RNA polymerase II transcription subunit 17 (Mediator complex subunit 17) (dMED17) (dTRAP80) MED17 Trap80 CG7957 Drosophila melanogaster (Fruit fly) TR35665_c5_g1_i1 Q62377 U2AFM_MOUSE 6.00E-40 GO:0005689; GO:0046872; GO:0005730; GO:0000166; GO:0030628; GO:0000245 U12-type spliceosomal complex; metal ion binding; nucleolus; nucleotide binding; pre-mRNA 3'-splice site binding; spliceosomal complex assembly IPR012677; IPR000504; IPR009145; IPR000571; "U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (U2AF35-related protein) (URP)" Zrsr2 U2af1-rs2 U2af1l2 U2af1rs2 Mus musculus (Mouse) TR35667_c0_g1_i1 Q5FVB2 LMO41_XENTR 2.00E-57 GO:0007369; GO:0007498; GO:0045665; GO:0045944; GO:0003712; GO:0006351; GO:0008270 "gastrulation; mesoderm development; negative regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; transcription cofactor activity; transcription, DNA-dependent; zinc ion binding" IPR001781; LIM domain transcription factor LMO4.1 (LIM domain only protein 4.1) (LMO-4.1) lmo4.1 lmo4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35667_c0_g1_i2 Q8UVR3 LMX1B_XENLA 4.00E-25 GO:0072013; GO:0030182; GO:0005634; GO:0039020; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "glomus development; neuron differentiation; nucleus; pronephric nephron tubule development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR017970; IPR001356; IPR009057; IPR001781; LIM homeobox transcription factor 1-beta.1 (LIM homeobox protein 1b) (Xlmx1b) lmx1b.1 lmx1b Xenopus laevis (African clawed frog) TR35669_c0_g1_i1 Q3B7D3 TECT2_RAT 3.00E-35 GO:0036038; GO:0042384; GO:0005737; GO:0016021; GO:0005932; GO:0007224 TCTN-B9D complex; cilium assembly; cytoplasm; integral to membrane; microtubule basal body; smoothened signaling pathway IPR011677; Tectonic-2 Tctn2 Tect2 Rattus norvegicus (Rat) TR35670_c0_g2_i3 Q6GN70 B9D2_XENLA 1.00E-95 GO:0036038; GO:0005813; GO:0042384; GO:0035085; GO:0043015; GO:0005932 TCTN-B9D complex; centrosome; cilium assembly; cilium axoneme; gamma-tubulin binding; microtubule basal body IPR010796; B9 domain-containing protein 2 b9d2 Xenopus laevis (African clawed frog) TR35671_c0_g1_i1 Q2NL00 GSTT1_BOVIN 3.00E-15 GO:0005737; GO:0004364 cytoplasm; glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase theta-1 (EC 2.5.1.18) (GST class-theta-1) GSTT1 Bos taurus (Bovine) TR35671_c1_g2_i1 A3KNI7 CCDB1_DANRE 1.00E-24 GO:0007049; GO:0005737; GO:0005634 cell cycle; cytoplasm; nucleus Cyclin-D1-binding protein 1 homolog (Zebrafish homolog of Maid) ccndbp1 zhm zgc:162082 Danio rerio (Zebrafish) (Brachydanio rerio) TR35672_c1_g1_i1 P18503 CAS4_EPHMU 3.00E-08 GO:0005581 collagen IPR008160; Short-chain collagen C4 (Fragment) Ephydatia muelleri (Mueller's freshwater sponge) TR35674_c0_g1_i1 Q99489 OXDD_HUMAN 2.00E-65 GO:0019478; GO:0003884; GO:0008445; GO:0006533; GO:0006531; GO:0048037; GO:0007625; GO:0042445; GO:0007320; GO:0005777 D-amino acid catabolic process; D-amino-acid oxidase activity; D-aspartate oxidase activity; aspartate catabolic process; aspartate metabolic process; cofactor binding; grooming behavior; hormone metabolic process; insemination; peroxisome IPR023209; IPR006181; IPR006076; D-aspartate oxidase (DASOX) (DDO) (EC 1.4.3.1) DDO Homo sapiens (Human) TR35675_c2_g1_i1 Q8WZ42 TITIN_HUMAN 4.00E-10 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR35675_c2_g2_i1 Q9P2K9 PTHD2_HUMAN 3.00E-107 GO:0042632; GO:0005783; GO:0008158; GO:0016021; GO:0031965; GO:0032368; GO:0007224 cholesterol homeostasis; endoplasmic reticulum; hedgehog receptor activity; integral to membrane; nuclear membrane; regulation of lipid transport; smoothened signaling pathway IPR004869; IPR003392; IPR000731; Patched domain-containing protein 2 (Protein dispatched homolog 3) PTCHD2 DISP3 KIAA1337 Homo sapiens (Human) TR35676_c4_g3_i2 P43689 TPM2_BIOGL 9.00E-48 IPR000533; Tropomyosin-2 (Tropomyosin II) (BgTMII) (TMII) Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail) TR35676_c4_g3_i6 Q9GZ71 TPM_HALDV 5.00E-35 IPR000533; Tropomyosin Haliotis diversicolor (Abalone) (Sulculus diversicolor) TR35676_c4_g3_i9 P43689 TPM2_BIOGL 7.00E-35 IPR000533; Tropomyosin-2 (Tropomyosin II) (BgTMII) (TMII) Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail) TR35677_c0_g1_i1 Q924W6 TRI66_MOUSE 7.00E-11 GO:0010369; GO:0045892; GO:0005634; GO:0008270 "chromocenter; negative regulation of transcription, DNA-dependent; nucleus; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR013083; Tripartite motif-containing protein 66 (Transcriptional intermediary factor 1 delta) Trim66 Tif1d Mus musculus (Mouse) TR35677_c0_g1_i3 Q5RBR6 SPRY3_PONAB 5.00E-30 IPR001870; IPR008985; IPR018355; IPR003877; SPRY domain-containing protein 3 SPRYD3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35678_c0_g1_i1 Q91XF4 RN167_MOUSE 4.00E-27 GO:0005737; GO:0012505; GO:0016021; GO:0045786; GO:0000209; GO:0004842; GO:0008270 cytoplasm; endomembrane system; integral to membrane; negative regulation of cell cycle; protein polyubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003137; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF167 (EC 6.3.2.-) (RING finger protein 167) Rnf167 Mus musculus (Mouse) TR35680_c3_g1_i1 P27659 RL3_MOUSE 0 GO:0071353; GO:0022625; GO:0005730; GO:0003735; GO:0006412 cellular response to interleukin-4; cytosolic large ribosomal subunit; nucleolus; structural constituent of ribosome; translation IPR000597; IPR019926; IPR009000; 60S ribosomal protein L3 (J1 protein) Rpl3 Mus musculus (Mouse) TR35680_c4_g1_i2 Q6C741 GPI11_YARLI 2.00E-21 GO:0006506; GO:0005789; GO:0016021 GPI anchor biosynthetic process; endoplasmic reticulum membrane; integral to membrane IPR009580; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Glycosylphosphatidylinositol anchor biosynthesis protein 11 GPI11 YALI0E03960g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR35680_c4_g1_i3 Q07326 PIGF_HUMAN 8.00E-36 GO:0006501; GO:0005789; GO:0004307; GO:0016021; GO:0016254 C-terminal protein lipidation; endoplasmic reticulum membrane; ethanolaminephosphotransferase activity; integral to membrane; preassembly of GPI anchor in ER membrane IPR009580; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Phosphatidylinositol-glycan biosynthesis class F protein (PIG-F) (GPI11 homolog) PIGF Homo sapiens (Human) TR35681_c0_g2_i1 Q96QE2 MYCT_HUMAN 3.00E-166 GO:0016021; GO:0005886; GO:0022891; GO:0055085 integral to membrane; plasma membrane; substrate-specific transmembrane transporter activity; transmembrane transport IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13) SLC2A13 Homo sapiens (Human) TR35681_c0_g2_i2 Q8BFW9 GTR12_MOUSE 8.00E-49 GO:0012505; GO:0015758; GO:0016021; GO:0016020; GO:0022891 endomembrane system; glucose transport; integral to membrane; membrane; substrate-specific transmembrane transporter activity IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 12 (Glucose transporter type 12) (GLUT-12)" Slc2a12 Glut12 Glut8 Mus musculus (Mouse) TR35681_c0_g2_i3 Q96QE2 MYCT_HUMAN 3.00E-170 GO:0016021; GO:0005886; GO:0022891; GO:0055085 integral to membrane; plasma membrane; substrate-specific transmembrane transporter activity; transmembrane transport IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13) SLC2A13 Homo sapiens (Human) TR35681_c0_g2_i4 O23492 INT4_ARATH 9.00E-90 GO:0016021; GO:0005366; GO:0005886 integral to membrane; myo-inositol:hydrogen symporter activity; plasma membrane IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; Inositol transporter 4 (Myo-inositol-proton symporter INT4) (Protein INOSITOL TRANSPORTER 4) INT4 At4g16480 dl4265w FCAALL.375 Arabidopsis thaliana (Mouse-ear cress) TR35681_c0_g2_i6 Q96QE2 MYCT_HUMAN 5.00E-170 GO:0016021; GO:0005886; GO:0022891; GO:0055085 integral to membrane; plasma membrane; substrate-specific transmembrane transporter activity; transmembrane transport IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13) SLC2A13 Homo sapiens (Human) TR35681_c0_g2_i7 Q8VZR6 INT1_ARATH 2.00E-62 GO:0016021; GO:0005366; GO:0009705 integral to membrane; myo-inositol:hydrogen symporter activity; plant-type vacuole membrane IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; Inositol transporter 1 INT1 At2g43330 T1O24.7 Arabidopsis thaliana (Mouse-ear cress) TR35682_c0_g1_i2 Q9HBD1 RC3H2_HUMAN 0 GO:0003677; GO:0003723; GO:0009986; GO:0000932; GO:0016020; GO:0008270 DNA binding; RNA binding; cell surface; cytoplasmic mRNA processing body; membrane; zinc ion binding IPR000571; IPR001841; IPR013083; IPR017907; Roquin-2 (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) RC3H2 MNAB RNF164 Homo sapiens (Human) TR35683_c0_g1_i1 Q86UP9 LHPL3_HUMAN 3.00E-38 GO:0016021 integral to membrane IPR019372; Lipoma HMGIC fusion partner-like 3 protein LHFPL3 LHFPL4 Homo sapiens (Human) TR35684_c1_g2_i1 Q4QRD7 F110B_DANRE 1.00E-08 GO:0005737; GO:0005815 cytoplasm; microtubule organizing center IPR025741; IPR025739; Protein FAM110B fam110b zgc:114139 Danio rerio (Zebrafish) (Brachydanio rerio) TR35684_c1_g2_i3 Q4QRD7 F110B_DANRE 9.00E-09 GO:0005737; GO:0005815 cytoplasm; microtubule organizing center IPR025741; IPR025739; Protein FAM110B fam110b zgc:114139 Danio rerio (Zebrafish) (Brachydanio rerio) TR35685_c1_g2_i1 P36573 LEC1_CAEEL 8.00E-30 GO:0030246; GO:0060102; GO:0016936 carbohydrate binding; collagen and cuticulin-based cuticle extracellular matrix; galactoside binding IPR008985; IPR013320; IPR001079; 32 kDa beta-galactoside-binding lectin (32 kDa GBP) lec-1 W09H1.6 Caenorhabditis elegans TR35685_c1_g2_i2 O54891 LEG6_MOUSE 7.00E-36 GO:0030246 carbohydrate binding IPR008985; IPR013320; IPR015533; IPR001079; Galectin-6 (Gal-6) Lgals6 Mus musculus (Mouse) TR35685_c1_g2_i3 P47967 LEG5_RAT 2.00E-20 GO:0030246 carbohydrate binding IPR008985; IPR013320; IPR001079; Galectin-5 (Gal-5) (RL-18) Lgals5 Rattus norvegicus (Rat) TR35687_c2_g1_i1 Q8BUJ9 LRP12_MOUSE 3.00E-07 GO:0005905; GO:0006897; GO:0005887 coated pit; endocytosis; integral to plasma membrane IPR000859; IPR023415; IPR002172; Low-density lipoprotein receptor-related protein 12 (LRP-12) Lrp12 Mus musculus (Mouse) TR35688_c2_g1_i1 Q9I926 FUCL6_ANGJA 3.00E-14 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-6 Anguilla japonica (Japanese eel) TR35688_c2_g1_i3 Q9I926 FUCL6_ANGJA 6.00E-14 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-6 Anguilla japonica (Japanese eel) TR35688_c3_g1_i2 Q9U4H5 AMX_DROME 2.00E-59 GO:0007220; GO:0007219; GO:0001713; GO:0044214; GO:0016021; GO:0046331; GO:0007498; GO:0045747 Notch receptor processing; Notch signaling pathway; ectodermal cell fate determination; fully spanning plasma membrane; integral to membrane; lateral inhibition; mesoderm development; positive regulation of Notch signaling pathway IPR007829; TM2 domain-containing protein almondex amx CG12127 Drosophila melanogaster (Fruit fly) TR35688_c3_g1_i4 Q9BRN9 TM2D3_HUMAN 2.00E-67 GO:0016021 integral to membrane IPR007829; TM2 domain-containing protein 3 (Beta-amyloid-binding protein-like protein 2) (BBP-like protein 2) TM2D3 BLP2 Homo sapiens (Human) TR35688_c3_g2_i1 Q5NVK5 PGTA_PONAB 2.00E-111 GO:0004663; GO:0018342; GO:0008270 Rab geranylgeranyltransferase activity; protein prenylation; zinc ion binding IPR001611; IPR002088; IPR009087; Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha) RABGGTA Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35688_c3_g3_i1 Q6AYH9 DAAF1_RAT 8.00E-08 GO:0035085; GO:0060271; GO:0003341; GO:0071907; GO:0071910; GO:0035469; GO:0045502; GO:0001947; GO:0036159; GO:0060972; GO:0030324; GO:0044458; GO:0005634; GO:0036158; GO:0005886; GO:0003356 cilium axoneme; cilium morphogenesis; cilium movement; determination of digestive tract left/right asymmetry; determination of liver left/right asymmetry; determination of pancreatic left/right asymmetry; dynein binding; heart looping; inner dynein arm assembly; left/right pattern formation; lung development; motile cilium assembly; nucleus; outer dynein arm assembly; plasma membrane; regulation of cilium beat frequency IPR027734; IPR001611; "Dynein assembly factor 1, axonemal (Leucine-rich repeat-containing protein 50)" Dnaaf1 Lrrc50 Rattus norvegicus (Rat) TR35690_c0_g1_i1 O01814 FABP5_CAEEL 1.00E-12 GO:0005504; GO:0005634; GO:0048471; GO:0005215 fatty acid binding; nucleus; perinuclear region of cytoplasm; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; Fatty acid-binding protein homolog 5 lbp-5 W02D3.7 Caenorhabditis elegans TR35690_c0_g1_i2 O01814 FABP5_CAEEL 1.00E-12 GO:0005504; GO:0005634; GO:0048471; GO:0005215 fatty acid binding; nucleus; perinuclear region of cytoplasm; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; Fatty acid-binding protein homolog 5 lbp-5 W02D3.7 Caenorhabditis elegans TR35691_c0_g1_i1 Q66IZ5 TAD3B_XENLA 2.00E-88 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019340; Transcriptional adapter 3-B (ADA3 homolog B) (Transcriptional adapter 3-like B) (ADA3-like protein B) tada3-b ada3-b tada3l-b Xenopus laevis (African clawed frog) TR35692_c0_g1_i1 P21328 RTJK_DROME 8.00E-13 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) TR35692_c0_g1_i2 Q9NBX4 RTXE_DROME 5.00E-10 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR35693_c0_g2_i1 Q6ZU11 YD002_HUMAN 4.00E-42 TR35693_c0_g2_i2 O76512 RENT1_CAEEL 1.00E-23 GO:0005524; GO:0004004; GO:0003677; GO:0003723; GO:0016246; GO:0005737; GO:0030538; GO:0000184; GO:0005634; GO:0008270 "ATP binding; ATP-dependent RNA helicase activity; DNA binding; RNA binding; RNA interference; cytoplasm; embryonic genitalia morphogenesis; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus; zinc ion binding" IPR003593; IPR027417; IPR018999; Regulator of nonsense transcripts 1 (EC 3.6.4.-) (ATP-dependent helicase smg-2) (Nonsense mRNA reducing factor 1) (Up-frameshift suppressor 1 homolog) smg-2 Y48G8AL.6 Caenorhabditis elegans TR35696_c0_g1_i1 P40830 PKSG_BACSU 3.00E-15 GO:0017000; GO:0005737; GO:0004421; GO:0008299 antibiotic biosynthetic process; cytoplasm; hydroxymethylglutaryl-CoA synthase activity; isoprenoid biosynthetic process IPR013746; IPR013528; IPR016039; IPR016038; Antibiotic biosynthesis; bacillaene biosynthesis. Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG (HMG synthase) (EC 2.3.3.-) pksG BSU17150 Bacillus subtilis (strain 168) TR35696_c0_g2_i1 Q5R7Z9 HMCS1_PONAB 0 GO:0006695; GO:0005737; GO:0004421; GO:0008299; GO:0005634; GO:0005886 cholesterol biosynthetic process; cytoplasm; hydroxymethylglutaryl-CoA synthase activity; isoprenoid biosynthetic process; nucleus; plasma membrane IPR000590; IPR013746; IPR013528; IPR010122; IPR016039; IPR016038; Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3. "Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)" HMGCS1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35697_c0_g1_i1 Q6NTY6 EGR1B_XENLA 7.00E-62 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR021839; IPR021849; IPR007087; IPR015880; IPR013087; Early growth response protein 1-B (EGR-1-B) egr1-b Xenopus laevis (African clawed frog) TR35697_c0_g1_i2 P08046 EGR1_MOUSE 7.00E-61 GO:0030509; GO:0000982; GO:0030217; GO:0071320; GO:0071480; GO:0071371; GO:0071504; GO:0071506; GO:0005737; GO:0072110; GO:0070498; GO:0046872; GO:0043066; GO:0090090; GO:0000122; GO:0005634; GO:0072303; GO:0045944; GO:0048169; GO:0033233; GO:0009749; GO:0032868; GO:0035914; GO:0044212; GO:0000976 BMP signaling pathway; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity; T cell differentiation; cellular response to cAMP; cellular response to gamma radiation; cellular response to gonadotropin stimulus; cellular response to heparin; cellular response to mycophenolic acid; cytoplasm; glomerular mesangial cell proliferation; interleukin-1-mediated signaling pathway; metal ion binding; negative regulation of apoptotic process; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of glomerular metanephric mesangial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of long-term neuronal synaptic plasticity; regulation of protein sumoylation; response to glucose stimulus; response to insulin stimulus; skeletal muscle cell differentiation; transcription regulatory region DNA binding; transcription regulatory region sequence-specific DNA binding IPR021839; IPR021849; IPR007087; IPR015880; IPR013087; Early growth response protein 1 (EGR-1) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor Zif268) (Zinc finger protein Krox-24) Egr1 Egr-1 Krox-24 Mus musculus (Mouse) TR35698_c4_g1_i1 P40806 PKSJ_BACSU 5.00E-27 GO:0017000; GO:0005737; GO:0016874; GO:0031177; GO:0016746 "antibiotic biosynthetic process; cytoplasm; ligase activity; phosphopantetheine binding; transferase activity, transferring acyl groups" IPR010071; IPR009081; IPR025110; IPR020845; IPR000873; IPR001242; IPR018201; IPR014031; IPR014030; IPR016040; IPR020842; IPR020841; IPR020807; IPR013968; IPR020806; IPR006162; IPR016039; IPR016038; Antibiotic biosynthesis; bacillaene biosynthesis. Polyketide synthase PksJ (PKS) pksJ pksK BSU17180 Bacillus subtilis (strain 168) TR35698_c4_g1_i2 Q02251 MCAS_MYCBO 7.00E-24 GO:0006633; GO:0016787; GO:0016874; GO:0050111; GO:0016491; GO:0005886; GO:0008270 fatty acid biosynthetic process; hydrolase activity; ligase activity; mycocerosate synthase activity; oxidoreductase activity; plasma membrane; zinc ion binding IPR001227; IPR009081; IPR014043; IPR016035; IPR013149; IPR013154; IPR011032; IPR018201; IPR014031; IPR014030; IPR016036; IPR016040; IPR020842; IPR020801; IPR020841; IPR020807; IPR020843; IPR013968; IPR006162; IPR016039; IPR016038; Mycocerosic acid synthase (EC 2.3.1.111) mas Mb2965c Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) TR35699_c2_g1_i3 A6NFD8 HELT_HUMAN 7.00E-07 GO:0003677; GO:0021858; GO:0007417; GO:0035264; GO:0010259; GO:0000122; GO:0005634; GO:0009791; GO:0003700; GO:0001967; GO:0005667; GO:0006351 "DNA binding; GABAergic neuron differentiation in basal ganglia; central nervous system development; multicellular organism growth; multicellular organismal aging; negative regulation of transcription from RNA polymerase II promoter; nucleus; post-embryonic development; sequence-specific DNA binding transcription factor activity; suckling behavior; transcription factor complex; transcription, DNA-dependent" IPR011598; IPR003650; Hairy and enhancer of split-related protein HELT (HES/HEY-like transcription factor) HELT Homo sapiens (Human) TR35699_c2_g2_i1 Q7TS99 HELT_MOUSE 2.00E-20 GO:0003677; GO:0021858; GO:0007417; GO:0010467; GO:0035264; GO:0010259; GO:0000122; GO:0005634; GO:0045944; GO:0009791; GO:0042803; GO:0003700; GO:0001967; GO:0005667; GO:0006351 "DNA binding; GABAergic neuron differentiation in basal ganglia; central nervous system development; gene expression; multicellular organism growth; multicellular organismal aging; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of transcription from RNA polymerase II promoter; post-embryonic development; protein homodimerization activity; sequence-specific DNA binding transcription factor activity; suckling behavior; transcription factor complex; transcription, DNA-dependent" IPR011598; IPR003650; Hairy and enhancer of split-related protein HELT (HES/HEY-like transcription factor) (Protein Hes-like) (Protein megane) Helt Hesl Mgn Mus musculus (Mouse) TR35699_c2_g2_i5 Q9QUS4 HEY2_MOUSE 9.00E-16 GO:0061314; GO:0000983; GO:0016580; GO:0009948; GO:0060842; GO:0035910; GO:0060413; GO:0003171; GO:0003214; GO:0014898; GO:0003215; GO:0060948; GO:0045165; GO:0090102; GO:0060977; GO:0005737; GO:0035912; GO:0003199; GO:0060347; GO:0060716; GO:0035939; GO:0003150; GO:0045746; GO:0010667; GO:2000820; GO:0060633; GO:2000678; GO:0005654; GO:0003151; GO:0060045; GO:0010460; GO:0045944; GO:0065004; GO:0061156; GO:0003184; GO:0045607; GO:2001212; GO:0005667; GO:0017053; GO:0003195; GO:0036304; GO:0001570; GO:0055015; GO:0003222 Notch signaling involved in heart development; RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; Sin3 complex; anterior/posterior axis specification; arterial endothelial cell differentiation; ascending aorta morphogenesis; atrial septum morphogenesis; atrioventricular valve development; cardiac left ventricle morphogenesis; cardiac muscle hypertrophy in response to stress; cardiac right ventricle morphogenesis; cardiac vascular smooth muscle cell development; cell fate commitment; cochlea development; coronary vasculature morphogenesis; cytoplasm; dorsal aorta morphogenesis; endocardial cushion to mesenchymal transition involved in heart valve formation; heart trabecula formation; labyrinthine layer blood vessel development; microsatellite binding; muscular septum morphogenesis; negative regulation of Notch signaling pathway; negative regulation of cardiac muscle cell apoptotic process; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; negative regulation of transcription initiation from RNA polymerase II promoter; negative regulation of transcription regulatory region DNA binding; nucleoplasm; outflow tract morphogenesis; positive regulation of cardiac muscle cell proliferation; positive regulation of heart rate; positive regulation of transcription from RNA polymerase II promoter; protein-DNA complex assembly; pulmonary artery morphogenesis; pulmonary valve morphogenesis; regulation of auditory receptor cell differentiation; regulation of vasculogenesis; transcription factor complex; transcriptional repressor complex; tricuspid valve formation; umbilical cord morphogenesis; vasculogenesis; ventricular cardiac muscle cell development; ventricular trabecula myocardium morphogenesis IPR011598; IPR003650; IPR018352; Hairy/enhancer-of-split related with YRPW motif protein 2 (HES-related repressor protein 2) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HRT-2) (mHRT2) (Protein gridlock homolog) Hey2 Chf1 Herp Herp1 Hesr2 Hrt2 Mus musculus (Mouse) TR35699_c2_g2_i6 Q7TS99 HELT_MOUSE 7.00E-20 GO:0003677; GO:0021858; GO:0007417; GO:0010467; GO:0035264; GO:0010259; GO:0000122; GO:0005634; GO:0045944; GO:0009791; GO:0042803; GO:0003700; GO:0001967; GO:0005667; GO:0006351 "DNA binding; GABAergic neuron differentiation in basal ganglia; central nervous system development; gene expression; multicellular organism growth; multicellular organismal aging; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of transcription from RNA polymerase II promoter; post-embryonic development; protein homodimerization activity; sequence-specific DNA binding transcription factor activity; suckling behavior; transcription factor complex; transcription, DNA-dependent" IPR011598; IPR003650; Hairy and enhancer of split-related protein HELT (HES/HEY-like transcription factor) (Protein Hes-like) (Protein megane) Helt Hesl Mgn Mus musculus (Mouse) TR35700_c0_g2_i2 A7Z061 CDC27_BOVIN 0 GO:0005680; GO:0070979 anaphase-promoting complex; protein K11-linked ubiquitination IPR013026; IPR001440; IPR013105; IPR019734; Protein modification; protein ubiquitination. Cell division cycle protein 27 homolog CDC27 Bos taurus (Bovine) TR35701_c1_g1_i2 Q9NDM2 GUTR1_DROME 1.00E-15 GO:0004930; GO:0005938; GO:0007281; GO:0035234; GO:0016021; GO:0005886; GO:0007280 G-protein coupled receptor activity; cell cortex; germ cell development; germ cell programmed cell death; integral to membrane; plasma membrane; pole cell migration IPR000276; IPR017452; Protein trapped in endoderm-1 Tre1 CG3171 Drosophila melanogaster (Fruit fly) TR35702_c0_g1_i1 O88278 CELR3_RAT 1.00E-16 GO:0004930; GO:0007413; GO:0005509; GO:0042384; GO:0007156; GO:0016021; GO:0001764; GO:0007218; GO:0005886; GO:0032880 G-protein coupled receptor activity; axonal fasciculation; calcium ion binding; cilium assembly; homophilic cell adhesion; integral to membrane; neuron migration; neuropeptide signaling pathway; plasma membrane; regulation of protein localization IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR013032; IPR002049; IPR017981; IPR001879; IPR000832; IPR017983; IPR000203; IPR001791; Cadherin EGF LAG seven-pass G-type receptor 3 (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) Celsr3 Megf2 Rattus norvegicus (Rat) TR35703_c0_g1_i1 Q498M4 WDR5_RAT 0 GO:0005671; GO:0071339; GO:0048188; GO:0043966; GO:0051568; GO:0043984; GO:0043981; GO:0043982; GO:0046972; GO:0043995; GO:0043996; GO:0000123; GO:0042800; GO:0035064; GO:0006355; GO:0001501; GO:0006351 "Ada2/Gcn5/Ada3 transcription activator complex; MLL1 complex; Set1C/COMPASS complex; histone H3 acetylation; histone H3-K4 methylation; histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase activity (H4-K16 specific); histone acetyltransferase activity (H4-K5 specific); histone acetyltransferase activity (H4-K8 specific); histone acetyltransferase complex; histone methyltransferase activity (H3-K4 specific); methylated histone residue binding; regulation of transcription, DNA-dependent; skeletal system development; transcription, DNA-dependent" IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 5 Wdr5 Rattus norvegicus (Rat) TR35704_c4_g1_i1 D4A6L0 GP158_RAT 3.00E-37 GO:0004930; GO:0016021; GO:0005886; GO:0072659; GO:0008277 G-protein coupled receptor activity; integral to membrane; plasma membrane; protein localization to plasma membrane; regulation of G-protein coupled receptor protein signaling pathway IPR017978; Probable G-protein coupled receptor 158 Gpr158 Rattus norvegicus (Rat) TR35704_c4_g1_i2 D4A6L0 GP158_RAT 2.00E-93 GO:0004930; GO:0016021; GO:0005886; GO:0072659; GO:0008277 G-protein coupled receptor activity; integral to membrane; plasma membrane; protein localization to plasma membrane; regulation of G-protein coupled receptor protein signaling pathway IPR017978; Probable G-protein coupled receptor 158 Gpr158 Rattus norvegicus (Rat) TR35709_c1_g1_i1 Q2EMV9 PAR14_MOUSE 5.00E-35 GO:0003950; GO:0005737; GO:0003676; GO:0005634; GO:0005886; GO:0006355; GO:0006351 P06745 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleic acid binding; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR000504; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) TR35709_c1_g1_i2 Q460N5 PAR14_HUMAN 9.00E-39 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR35709_c1_g1_i3 Q926Y8 Y2902_LISIN 3.00E-09 IPR002589; Macro domain-containing protein lin2902 lin2902 Listeria innocua serovar 6a (strain CLIP 11262) TR35709_c1_g1_i4 C9Y0V8 YMDB_CROTZ 2.00E-10 GO:0019213; GO:0060701; GO:0001883; GO:0042278; GO:0008428 deacetylase activity; negative regulation of ribonuclease activity; purine nucleoside binding; purine nucleoside metabolic process; ribonuclease inhibitor activity IPR002589; IPR024900; O-acetyl-ADP-ribose deacetylase (EC 3.5.1.-) (Regulator of RNase III activity) ymdB Ctu_16240 Cronobacter turicensis (strain DSM 18703 / LMG 23827 / z3032) TR35709_c1_g1_i5 Q8BZ20 PAR12_MOUSE 8.00E-13 GO:0003950; GO:0046872; GO:0005634 NAD+ ADP-ribosyltransferase activity; metal ion binding; nucleus IPR012317; IPR004170; IPR000571; Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) Parp12 Zc3hdc1 Mus musculus (Mouse) TR35710_c1_g2_i1 Q9UKF6 CPSF3_HUMAN 0 GO:0008409; GO:0003723; GO:0004521; GO:0006398; GO:0006379; GO:0005847; GO:0006406; GO:0006378; GO:0000398; GO:0046872; GO:0030529; GO:0006369 "5'-3' exonuclease activity; RNA binding; endoribonuclease activity; histone mRNA 3'-end processing; mRNA cleavage; mRNA cleavage and polyadenylation specificity factor complex; mRNA export from nucleus; mRNA polyadenylation; mRNA splicing, via spliceosome; metal ion binding; ribonucleoprotein complex; termination of RNA polymerase II transcription" IPR001279; IPR022712; IPR021718; IPR011108; Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73) CPSF3 CPSF73 Homo sapiens (Human) TR35712_c0_g1_i1 P62154 CALM_LOCMI 4.00E-97 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Locusta migratoria (Migratory locust) TR35717_c2_g1_i1 Q2TBX4 HSP13_BOVIN 4.00E-143 GO:0005524; GO:0005783 ATP binding; endoplasmic reticulum IPR018181; IPR013126; Heat shock 70 kDa protein 13 (Stress-70 protein chaperone microsome-associated 60 kDa protein) HSPA13 STCH Bos taurus (Bovine) TR35720_c0_g3_i2 Q3ZBG9 PLS2_BOVIN 7.00E-59 GO:0016021; GO:0046872 integral to membrane; metal ion binding IPR005552; Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) TR35720_c0_g3_i3 Q9NRQ2 PLS4_HUMAN 6.00E-32 GO:0007596; GO:0005509; GO:0071222; GO:0016021; GO:0017128; GO:0005886 P09022 blood coagulation; calcium ion binding; cellular response to lipopolysaccharide; integral to membrane; phospholipid scramblase activity; plasma membrane IPR005552; Phospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependent phospholipid scramblase 4) (Cell growth-inhibiting gene 43 protein) (TRA1) PLSCR4 GIG43 Homo sapiens (Human) TR35721_c0_g1_i3 Q9R0C0 PLDN_MOUSE 4.00E-15 GO:0031083; GO:0031201; GO:0051015; GO:0008089; GO:0048490; GO:0007596; GO:0012505; GO:0005768; GO:0035646; GO:0019898; GO:0030318; GO:0032402; GO:0031175; GO:0032816; GO:0050942; GO:0042803; GO:0033299; GO:0030133; GO:0006904; GO:0006906 BLOC-1 complex; SNARE complex; actin filament binding; anterograde axon cargo transport; anterograde synaptic vesicle transport; blood coagulation; endomembrane system; endosome; endosome to melanosome transport; extrinsic to membrane; melanocyte differentiation; melanosome transport; neuron projection development; positive regulation of natural killer cell activation; positive regulation of pigment cell differentiation; protein homodimerization activity; secretion of lysosomal enzymes; transport vesicle; vesicle docking involved in exocytosis; vesicle fusion IPR017242; IPR028119; Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) (Pallid protein) (Pallidin) (Syntaxin 13-interacting protein) Bloc1s6 P2 Pa Pldn Mus musculus (Mouse) TR35721_c0_g1_i4 Q9UL45 PLDN_HUMAN 1.00E-14 GO:0031083; GO:0051015; GO:0008089; GO:0048490; GO:0007596; GO:0012505; GO:0005768; GO:0035646; GO:0019898; GO:0030318; GO:0032438; GO:0032402; GO:0031175; GO:0032816; GO:0050942; GO:0006892; GO:0042803; GO:0033299; GO:0016081; GO:0019905; GO:0030133 Itself; P78537; Q6QNY1; Q6QNY0; Q9NUP1; Q8TDH9; Q96EV8; O95295 BLOC-1 complex; actin filament binding; anterograde axon cargo transport; anterograde synaptic vesicle transport; blood coagulation; endomembrane system; endosome; endosome to melanosome transport; extrinsic to membrane; melanocyte differentiation; melanosome organization; melanosome transport; neuron projection development; positive regulation of natural killer cell activation; positive regulation of pigment cell differentiation; post-Golgi vesicle-mediated transport; protein homodimerization activity; secretion of lysosomal enzymes; synaptic vesicle docking involved in exocytosis; syntaxin binding; transport vesicle IPR017242; IPR028119; Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) (Pallid protein homolog) (Pallidin) (Syntaxin 13-interacting protein) BLOC1S6 PA PLDN Homo sapiens (Human) TR35722_c1_g1_i1 O35465 FKBP8_MOUSE 9.00E-56 GO:0005528; GO:0006915; GO:0043010; GO:0001708; GO:0021904; GO:0030176; GO:0005740; GO:0031966; GO:0035264; GO:0043066; GO:0003755; GO:0030513; GO:0006457; GO:0010468; GO:0007224 FK506 binding; apoptotic process; camera-type eye development; cell fate specification; dorsal/ventral neural tube patterning; integral to endoplasmic reticulum membrane; mitochondrial envelope; mitochondrial membrane; multicellular organism growth; negative regulation of apoptotic process; peptidyl-prolyl cis-trans isomerase activity; positive regulation of BMP signaling pathway; protein folding; regulation of gene expression; smoothened signaling pathway IPR023114; IPR023566; IPR001179; IPR013026; IPR011990; IPR001440; IPR019734; Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (mFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) Fkbp8 Fkbp38 Sam11 Mus musculus (Mouse) TR35724_c2_g1_i1 P00636 F16P1_PIG 7.00E-140 GO:0016208; GO:0035690; GO:0071286; GO:0005829; GO:0042132; GO:0006002; GO:0006094; GO:0046872; GO:0048029; GO:0046580; GO:0030308; GO:0045820; GO:0051289; GO:0006111 "AMP binding; cellular response to drug; cellular response to magnesium ion; cytosol; fructose 1,6-bisphosphate 1-phosphatase activity; fructose 6-phosphate metabolic process; gluconeogenesis; metal ion binding; monosaccharide binding; negative regulation of Ras protein signal transduction; negative regulation of cell growth; negative regulation of glycolysis; protein homotetramerization; regulation of gluconeogenesis" IPR000146; IPR028343; IPR020548; Carbohydrate biosynthesis; gluconeogenesis. "Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1)" FBP1 FBP Sus scrofa (Pig) TR35724_c2_g1_i2 Q6RYT0 F16P_DICDI 1.00E-100 GO:0005829; GO:0042132; GO:0006000; GO:0006094; GO:0046872 "cytosol; fructose 1,6-bisphosphate 1-phosphatase activity; fructose metabolic process; gluconeogenesis; metal ion binding" IPR000146; IPR028343; IPR020548; Carbohydrate biosynthesis; gluconeogenesis. "Fructose-1,6-bisphosphatase (FBPase) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase)" fbp DDB_G0270836 Dictyostelium discoideum (Slime mold) TR35725_c0_g2_i1 A4II71 BRM1L_XENTR 2.00E-62 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR013907; Breast cancer metastasis-suppressor 1-like protein brms1l Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35726_c0_g1_i1 P86854 PLCL_MYTGA 2.00E-28 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR35726_c0_g1_i2 P86854 PLCL_MYTGA 3.00E-28 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR35726_c0_g1_i3 Q91ZW8 C209D_MOUSE 2.00E-17 GO:0042742; GO:0006897; GO:0016021; GO:0005537; GO:0046872; GO:0050715 defense response to bacterium; endocytosis; integral to membrane; mannose binding; metal ion binding; positive regulation of cytokine secretion IPR001304; IPR016186; IPR018378; IPR016187; CD209 antigen-like protein D (DC-SIGN-related protein 3) (DC-SIGNR3) (CD antigen CD209) Cd209d Mus musculus (Mouse) TR35726_c0_g1_i4 Q8HY00 CD209_PONPY 2.00E-16 GO:0007155; GO:0006897; GO:0045087; GO:0016021; GO:0005537; GO:0046872 cell adhesion; endocytosis; innate immune response; integral to membrane; mannose binding; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; CD209 antigen (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN1) (CD antigen CD209) CD209 Pongo pygmaeus (Bornean orangutan) TR35728_c0_g2_i1 Q24248 ARA_DROME 2.00E-57 GO:0003705; GO:0045317; GO:0007474; GO:0042693; GO:0035310; GO:0005634; GO:0045944; GO:0043565 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; equator specification; imaginal disc-derived wing vein specification; muscle cell fate commitment; notum cell fate specification; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding IPR017970; IPR001356; IPR008422; IPR009057; Homeobox protein araucan ara CG10571 Drosophila melanogaster (Fruit fly) TR35732_c0_g1_i2 Q90YT3 RL35A_ICTPU 2.00E-33 GO:0005840; GO:0003735; GO:0000049; GO:0006412 ribosome; structural constituent of ribosome; tRNA binding; translation IPR001780; IPR018266; IPR009000; 60S ribosomal protein L35a rpl35a Ictalurus punctatus (Channel catfish) (Silurus punctatus) TR35732_c0_g1_i3 Q56JY1 RL35A_BOVIN 1.00E-32 GO:0005840; GO:0003735; GO:0000049; GO:0006412 ribosome; structural constituent of ribosome; tRNA binding; translation IPR001780; IPR018266; IPR009000; 60S ribosomal protein L35a RPL35A Bos taurus (Bovine) TR35734_c2_g1_i1 O00443 P3C2A_HUMAN 9.00E-52 GO:0016303; GO:0035005; GO:0005524; GO:0005794; GO:0048268; GO:0030136; GO:0006897; GO:0007173; GO:0006887; GO:0008286; GO:0005634; GO:0005942; GO:0035091; GO:0048015; GO:0005886; GO:0048008; GO:0044281; GO:0014829; GO:0031982 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; Golgi apparatus; clathrin coat assembly; clathrin-coated vesicle; endocytosis; epidermal growth factor receptor signaling pathway; exocytosis; insulin receptor signaling pathway; nucleus; phosphatidylinositol 3-kinase complex; phosphatidylinositol binding; phosphatidylinositol-mediated signaling; plasma membrane; platelet-derived growth factor receptor signaling pathway; small molecule metabolic process; vascular smooth muscle contraction; vesicle IPR016024; IPR000008; IPR011009; IPR001683; IPR000403; IPR018936; IPR002420; IPR000341; IPR015433; IPR001263; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) PIK3C2A Homo sapiens (Human) TR35734_c4_g1_i1 P37801 CLPH_ONCVO 6.00E-24 IPR000557; Calponin homolog OV9M Onchocerca volvulus TR35734_c4_g1_i2 P37397 CNN3_RAT 8.00E-15 GO:0005884; GO:0031032; GO:0043197; GO:0005874; GO:0008017; GO:0032780; GO:0043025; GO:0014069; GO:0030674 "actin filament; actomyosin structure organization; dendritic spine; microtubule; microtubule binding; negative regulation of ATPase activity; neuronal cell body; postsynaptic density; protein binding, bridging" IPR001997; IPR000557; IPR001715; IPR003096; "Calponin-3 (Calponin, acidic isoform) (Calponin, non-muscle isoform)" Cnn3 Rattus norvegicus (Rat) TR35734_c4_g1_i3 Q08094 CNN2_PIG 1.00E-13 GO:0031032 actomyosin structure organization IPR001997; IPR000557; IPR001715; IPR003096; "Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin) (Fragment)" CNN2 Sus scrofa (Pig) TR35734_c6_g1_i1 O00750 P3C2B_HUMAN 4.00E-48 GO:0016303; GO:0035005; GO:0005524; GO:0030139; GO:0005783; GO:0043231; GO:0001727; GO:0005634; GO:0005942; GO:0035091; GO:0048015; GO:0005886; GO:0043491; GO:0044281 P00533; P04626; P62993; P16333; P14373 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; endocytic vesicle; endoplasmic reticulum; intracellular membrane-bounded organelle; lipid kinase activity; nucleus; phosphatidylinositol 3-kinase complex; phosphatidylinositol binding; phosphatidylinositol-mediated signaling; plasma membrane; protein kinase B signaling cascade; small molecule metabolic process IPR016024; IPR000008; IPR011009; IPR001683; IPR000403; IPR018936; IPR002420; IPR000341; IPR015433; IPR001263; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta) PIK3C2B Homo sapiens (Human) TR35734_c6_g2_i1 P37801 CLPH_ONCVO 1.00E-28 IPR000557; Calponin homolog OV9M Onchocerca volvulus TR35734_c6_g2_i4 Q55E26 GXCB_DICDI 4.00E-11 GO:0005089; GO:0051764; GO:0051015; GO:0005938; GO:0006897; GO:0006887; GO:0035556; GO:0005770; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; actin crosslink formation; actin filament binding; cell cortex; endocytosis; exocytosis; intracellular signal transduction; late endosome; phospholipid binding; regulation of Rho protein signal transduction IPR001715; IPR000219; IPR001331; IPR011993; IPR001849; IPR003096; Rac guanine nucleotide exchange factor B gxcB Trix DDB_G0269424 Dictyostelium discoideum (Slime mold) TR35734_c6_g2_i5 P26932 CNN1_CHICK 9.00E-39 GO:0031032 P68135 actomyosin structure organization IPR001997; IPR000557; IPR001715; IPR003096; "Calponin-1 (Calponin, smooth muscle)" CNN1 Gallus gallus (Chicken) TR35734_c6_g3_i1 Q22258 ATR_CAEEL 6.00E-09 GO:0016303; GO:0005524; GO:0003677; GO:0006281; GO:0000794; GO:0009790; GO:0045132; GO:0004674 1-phosphatidylinositol-3-kinase activity; ATP binding; DNA binding; DNA repair; condensed nuclear chromosome; embryo development; meiotic chromosome segregation; protein serine/threonine kinase activity IPR003152; IPR011009; IPR000403; IPR014009; Serine/threonine-protein kinase ATR (EC 2.7.11.1) (ATM-like protein 1) (Ataxia telangiectasia and Rad3-related protein homolog) (ATR homolog) (Ce-atl-1) atl-1 T06E4.3 Caenorhabditis elegans TR35734_c6_g4_i1 O70173 P3C2G_RAT 4.00E-115 GO:0016303; GO:0035005; GO:0005524; GO:0005794; GO:0006935; GO:0005635; GO:0005942; GO:0035091; GO:0048015; GO:0005886 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; Golgi apparatus; chemotaxis; nuclear envelope; phosphatidylinositol 3-kinase complex; phosphatidylinositol binding; phosphatidylinositol-mediated signaling; plasma membrane IPR016024; IPR000008; IPR011009; IPR001683; IPR000403; IPR018936; IPR002420; IPR000341; IPR015433; IPR001263; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma (PI3K-C2-gamma) (PtdIns-3-kinase C2 subunit gamma) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-gamma) Pik3c2g Rattus norvegicus (Rat) TR35734_c6_g4_i2 Q5RAY1 P3C2A_PONAB 8.00E-134 GO:0035005; GO:0005524; GO:0005794; GO:0030136; GO:0005737; GO:0006897; GO:0006887; GO:0005634; GO:0035091; GO:0048015; GO:0005886; GO:0031982 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; Golgi apparatus; clathrin-coated vesicle; cytoplasm; endocytosis; exocytosis; nucleus; phosphatidylinositol binding; phosphatidylinositol-mediated signaling; plasma membrane; vesicle IPR016024; IPR000008; IPR011009; IPR001683; IPR000403; IPR018936; IPR002420; IPR000341; IPR015433; IPR001263; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) PIK3C2A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35734_c6_g5_i1 P41436 IAP_GVCPM 4.00E-14 GO:0006915; GO:0008270 apoptotic process; zinc ion binding IPR001370; IPR001841; Apoptosis inhibitor IAP IAP Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) TR35735_c0_g1_i1 Q0VDI3 CE028_HUMAN 6.00E-32 GO:0016021 integral to membrane IPR026572; Transmembrane protein C5orf28 C5orf28 Homo sapiens (Human) TR35735_c0_g1_i5 Q8VDR5 CE028_MOUSE 5.00E-36 GO:0016021 integral to membrane IPR026572; Transmembrane protein C5orf28 homolog Gm7120 Mus musculus (Mouse) TR35737_c1_g2_i4 Q504A5 TPMT_DANRE 1.00E-71 GO:0005737; GO:0008119 cytoplasm; thiopurine S-methyltransferase activity IPR025835; IPR008854; Probable thiopurine S-methyltransferase (Thiopurine methyltransferase) (EC 2.1.1.67) tpmt zgc:109981 Danio rerio (Zebrafish) (Brachydanio rerio) TR35737_c1_g2_i9 Q504A5 TPMT_DANRE 3.00E-72 GO:0005737; GO:0008119 cytoplasm; thiopurine S-methyltransferase activity IPR025835; IPR008854; Probable thiopurine S-methyltransferase (Thiopurine methyltransferase) (EC 2.1.1.67) tpmt zgc:109981 Danio rerio (Zebrafish) (Brachydanio rerio) TR35738_c0_g1_i1 P54611 VATE_DROME 3.00E-70 GO:0015991; GO:0033181; GO:0046961; GO:0000221 "ATP hydrolysis coupled proton transport; plasma membrane proton-transporting V-type ATPase complex; proton-transporting ATPase activity, rotational mechanism; vacuolar proton-transporting V-type ATPase, V1 domain" IPR002842; V-type proton ATPase subunit E (V-ATPase subunit E) (V-ATPase 26 kDa subunit) (Vacuolar proton pump subunit E) Vha26 CG1088 Drosophila melanogaster (Fruit fly) TR35738_c0_g1_i2 P31402 VATE_MANSE 2.00E-65 GO:0015991; GO:0046961; GO:0033178 "ATP hydrolysis coupled proton transport; proton-transporting ATPase activity, rotational mechanism; proton-transporting two-sector ATPase complex, catalytic domain" IPR002842; V-type proton ATPase subunit E (V-ATPase subunit E) (V-ATPase 26 kDa subunit) (Vacuolar proton pump subunit E) VHA26 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) TR35740_c0_g1_i3 Q9LNJ9 FKGP_ARATH 6.00E-46 GO:0005524; GO:0042352; GO:0005975; GO:0005737; GO:0050201; GO:0047341; GO:0046872 ATP binding; GDP-L-fucose salvage; carbohydrate metabolic process; cytoplasm; fucokinase activity; fucose-1-phosphate guanylyltransferase activity; metal ion binding IPR012887; IPR013750; IPR006204; IPR006206; IPR020568; IPR014721; Bifunctional fucokinase/fucose pyrophosphorylase (AtFKGP) [Includes: L-fucokinase (EC 2.7.1.52); Fucose-1-phosphate guanylyltransferase (EC 2.7.7.30) (GDP-fucose pyrophosphorylase)] FKGP At1g01220 F6F3.3 Arabidopsis thaliana (Mouse-ear cress) TR35740_c0_g2_i2 Q8N0W3 FUK_HUMAN 1.00E-140 GO:0005524; GO:0005737; GO:0050201 ATP binding; cytoplasm; fucokinase activity IPR012887; IPR013750; IPR006204; IPR006206; IPR020568; IPR014721; L-fucose kinase (Fucokinase) (EC 2.7.1.52) FUK Homo sapiens (Human) TR35741_c1_g2_i1 A4ZGQ8 HMT1_BRAOT 1.00E-60 GO:0008898; GO:0046872 homocysteine S-methyltransferase activity; metal ion binding IPR003726; Homocysteine S-methyltransferase 1 (BoHMT1) (EC 2.1.1.10) HMT1 Brassica oleracea var. italica (Broccoli) TR35741_c1_g2_i2 Q87L95 METH_VIBPA 5.00E-08 GO:0031419; GO:0008898; GO:0005622; GO:0008705; GO:0042558; GO:0008270 cobalamin binding; homocysteine S-methyltransferase activity; intracellular; methionine synthase activity; pteridine-containing compound metabolic process; zinc ion binding IPR003759; IPR006158; IPR011005; IPR011822; IPR000489; IPR003726; IPR004223; Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1. "Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Methionine synthase, vitamin-B12 dependent) (MS)" metH VP2717 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) TR35741_c1_g2_i4 Q12525 MHT1_YEAST 2.00E-16 GO:0005737; GO:0008898; GO:0046872; GO:0009086; GO:0000096 Q12043 cytoplasm; homocysteine S-methyltransferase activity; metal ion binding; methionine biosynthetic process; sulfur amino acid metabolic process IPR003726; Homocysteine S-methyltransferase 1 (EC 2.1.1.10) (S-methylmethionine:homocysteine methyltransferase 1) (SMM:Hcy S-methyltransferase 1) MHT1 YLL062C L0552 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR35745_c0_g2_i1 Q1HG43 DOXA1_HUMAN 4.00E-52 GO:0005789; GO:0016021; GO:0005886; GO:0045666; GO:2000379; GO:0015031 endoplasmic reticulum membrane; integral to membrane; plasma membrane; positive regulation of neuron differentiation; positive regulation of reactive oxygen species metabolic process; protein transport IPR018469; Dual oxidase maturation factor 1 (Dual oxidase activator 1) (Numb-interacting protein) DUOXA1 NIP NUMBIP Homo sapiens (Human) TR35745_c0_g2_i3 Q1HG43 DOXA1_HUMAN 2.00E-36 GO:0005789; GO:0016021; GO:0005886; GO:0045666; GO:2000379; GO:0015031 endoplasmic reticulum membrane; integral to membrane; plasma membrane; positive regulation of neuron differentiation; positive regulation of reactive oxygen species metabolic process; protein transport IPR018469; Dual oxidase maturation factor 1 (Dual oxidase activator 1) (Numb-interacting protein) DUOXA1 NIP NUMBIP Homo sapiens (Human) TR35746_c1_g1_i1 P51589 CP2J2_HUMAN 5.00E-50 GO:0008405; GO:0008404; GO:0070330; GO:0005789; GO:0019373; GO:0020037; GO:0005506; GO:0071614; GO:0043651; GO:0008016; GO:0006805 "arachidonic acid 11,12-epoxygenase activity; arachidonic acid 14,15-epoxygenase activity; aromatase activity; endoplasmic reticulum membrane; epoxygenase P450 pathway; heme binding; iron ion binding; linoleic acid epoxygenase activity; linoleic acid metabolic process; regulation of heart contraction; xenobiotic metabolic process" IPR001128; IPR017972; IPR002401; IPR008071; Cytochrome P450 2J2 (EC 1.14.14.1) (Arachidonic acid epoxygenase) (CYPIIJ2) CYP2J2 Homo sapiens (Human) TR35746_c1_g1_i2 P12789 CP2B5_RABIT 1.00E-52 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; IPR008068; Cytochrome P450 2B5 (EC 1.14.14.1) (CYPIIB5) (Cytochrome P450 form HP1) (Cytochrome P450 type B2) CYP2B5 Oryctolagus cuniculus (Rabbit) TR35750_c3_g1_i1 Q8NFJ9 BBS1_HUMAN 4.00E-95 GO:0034464; GO:0043001; GO:0060170; GO:0005737; GO:0005815; GO:0035058; GO:0045494; GO:0050896; GO:0007601 P05062; Q9H0F7; Q9BXC9; Q96RK4; Q8IWZ6; Q3SYG4; P68104; P48356-1; Q15154; Q96QF0-1 BBSome; Golgi to plasma membrane protein transport; cilium membrane; cytoplasm; microtubule organizing center; nonmotile primary cilium assembly; photoreceptor cell maintenance; response to stimulus; visual perception IPR011047; Bardet-Biedl syndrome 1 protein (BBS2-like protein 2) BBS1 BBS2L2 Homo sapiens (Human) TR35750_c3_g3_i2 P07031 ACYP2_CHICK 5.00E-25 GO:0003998; GO:0005739 acylphosphatase activity; mitochondrion IPR020456; IPR027147; IPR001792; IPR017968; "Acylphosphatase-2 (EC 3.6.1.7) (Acylphosphatase isozyme CH1) (Acylphosphatase, muscle type isozyme) (Acylphosphate phosphohydrolase 2)" ACYP2 Gallus gallus (Chicken) TR35752_c0_g1_i1 A7Z052 WDR6_BOVIN 2.00E-102 GO:0008180; GO:0007050; GO:0005737; GO:0010507; GO:0008285 COP9 signalosome; cell cycle arrest; cytoplasm; negative regulation of autophagy; negative regulation of cell proliferation IPR015943; IPR001680; IPR017986; WD repeat-containing protein 6 WDR6 Bos taurus (Bovine) TR35754_c2_g1_i2 P07902 GALT_HUMAN 1.00E-170 GO:0005794; GO:0006258; GO:0008108; GO:0005829; GO:0019388; GO:0044281; GO:0008270 Golgi apparatus; UDP-glucose catabolic process; UDP-glucose:hexose-1-phosphate uridylyltransferase activity; cytosol; galactose catabolic process; small molecule metabolic process; zinc ion binding IPR001937; IPR019779; IPR005850; IPR005849; IPR011146; Carbohydrate metabolism; galactose metabolism. Galactose-1-phosphate uridylyltransferase (Gal-1-P uridylyltransferase) (EC 2.7.7.12) (UDP-glucose--hexose-1-phosphate uridylyltransferase) GALT Homo sapiens (Human) TR35755_c2_g1_i1 P86854 PLCL_MYTGA 3.00E-07 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR35756_c0_g1_i2 Q80Y56 RBNS5_MOUSE 2.00E-56 GO:0031901; GO:0046872; GO:0005886; GO:0015031 early endosome membrane; metal ion binding; plasma membrane; protein transport IPR021565; IPR007087; IPR015880; IPR000306; IPR017455; IPR011011; IPR013083; Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) Zfyve20 Mus musculus (Mouse) TR35758_c1_g2_i3 Q6DFK2 S2540_XENLA 5.00E-16 GO:0016021; GO:0005743; GO:0055085 integral to membrane; mitochondrial inner membrane; transmembrane transport IPR002067; IPR018108; IPR023395; Solute carrier family 25 member 40 slc25a40 Xenopus laevis (African clawed frog) TR35759_c2_g1_i1 Q9SSF8 CDPKU_ARATH 1.00E-08 GO:0005524; GO:0009738; GO:0005509; GO:0005886; GO:0004672; GO:0004674 P25854; P59220; Q9S744 ATP binding; abscisic acid mediated signaling pathway; calcium ion binding; plasma membrane; protein kinase activity; protein serine/threonine kinase activity IPR011992; IPR018247; IPR002048; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium-dependent protein kinase 30 (EC 2.7.11.1) (Calcium-dependent protein kinase isoform CDPK1a) (AtCDPK1a) CPK30 CDPK1A At1g74740 F25A4.29 Arabidopsis thaliana (Mouse-ear cress) TR35759_c2_g1_i2 Q12798 CETN1_HUMAN 2.00E-76 GO:0005524; GO:0008026; GO:0005509; GO:0051301; GO:0034605; GO:0005813; GO:0005737; GO:0007067; GO:0003676; GO:0032391; GO:0000922 ATP binding; ATP-dependent helicase activity; calcium ion binding; cell division; cellular response to heat; centrosome; cytoplasm; mitosis; nucleic acid binding; photoreceptor connecting cilium; spindle pole IPR011992; IPR018247; IPR002048; IPR000629; Centrin-1 (Caltractin isoform 2) CETN1 CEN1 CETN Homo sapiens (Human) TR35760_c0_g2_i2 Q9W0E8 ZER1_DROME 7.00E-131 GO:0031462; GO:0051438; GO:0004842 Cul2-RING ubiquitin ligase complex; regulation of ubiquitin-protein ligase activity; ubiquitin-protein ligase activity IPR011989; IPR016024; Protein zer-1 homolog (Zyg-11 homolog B-like protein) CG12084 Drosophila melanogaster (Fruit fly) TR35760_c0_g2_i3 Q9W0E8 ZER1_DROME 3.00E-153 GO:0031462; GO:0051438; GO:0004842 Cul2-RING ubiquitin ligase complex; regulation of ubiquitin-protein ligase activity; ubiquitin-protein ligase activity IPR011989; IPR016024; Protein zer-1 homolog (Zyg-11 homolog B-like protein) CG12084 Drosophila melanogaster (Fruit fly) TR35761_c0_g1_i2 Q9QZB9 DCTN5_MOUSE 2.00E-88 GO:0005813; GO:0000777; GO:0005737 centrosome; condensed chromosome kinetochore; cytoplasm IPR001451; IPR011004; Dynactin subunit 5 (Dynactin subunit p25) Dctn5 Mus musculus (Mouse) TR35763_c4_g1_i1 Q6R7G0 Y068_OSHVF 2.00E-21 GO:0033644; GO:0016021 host cell membrane; integral to membrane Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) TR35766_c0_g1_i1 P10155 RO60_HUMAN 4.00E-51 GO:0003723; GO:0060271; GO:0005737; GO:0046872; GO:0005634; GO:0030529; GO:0006383 Q9UHX1 RNA binding; cilium morphogenesis; cytoplasm; metal ion binding; nucleus; ribonucleoprotein complex; transcription from RNA polymerase III promoter IPR008858; IPR018698; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) TR35766_c0_g2_i1 Q9RUW8 RO60_DEIRA 2.00E-17 GO:0003723; GO:0005737; GO:0046872; GO:0030529 RNA binding; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein homolog (Ro sixty-related protein) rsr DR_1262 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) TR35767_c1_g2_i1 Q9ESN6 TRIM2_MOUSE 8.00E-06 GO:0005737; GO:0017022; GO:0043523; GO:0004842; GO:0008270 cytoplasm; myosin binding; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) TR35768_c1_g1_i1 Q8BSF5 KLH38_MOUSE 4.00E-09 IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 38 Klhl38 Mus musculus (Mouse) TR35768_c2_g2_i1 Q5RG82 NS1BA_DANRE 8.00E-75 GO:0005737; GO:0005856; GO:0005634 cytoplasm; cytoskeleton; nucleus IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Influenza virus NS1A-binding protein homolog A (NS1-BP homolog A) (NS1-binding protein homolog A) ivns1abpa si:dkeyp-11g8.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR35768_c2_g3_i1 Q973G3 Y939_SULTO 5.00E-07 IPR003961; IPR011043; IPR013783; IPR015915; IPR006652; Kelch domain-containing protein STK_09390 STK_09390 Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) TR35768_c2_g5_i1 Q5RG82 NS1BA_DANRE 6.00E-20 GO:0005737; GO:0005856; GO:0005634 cytoplasm; cytoskeleton; nucleus IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Influenza virus NS1A-binding protein homolog A (NS1-BP homolog A) (NS1-binding protein homolog A) ivns1abpa si:dkeyp-11g8.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR35769_c0_g1_i1 P54687 BCAT1_HUMAN 2.00E-158 GO:0000082; GO:0052656; GO:0052654; GO:0052655; GO:0009082; GO:0009083; GO:0004084; GO:0008283; GO:0034641; GO:0005829; GO:0005739 G1/S transition of mitotic cell cycle; L-isoleucine transaminase activity; L-leucine transaminase activity; L-valine transaminase activity; branched-chain amino acid biosynthetic process; branched-chain amino acid catabolic process; branched-chain-amino-acid transaminase activity; cell proliferation; cellular nitrogen compound metabolic process; cytosol; mitochondrion IPR001544; IPR018300; IPR005786; "Branched-chain-amino-acid aminotransferase, cytosolic (BCAT(c)) (EC 2.6.1.42) (Protein ECA39)" BCAT1 BCT1 ECA39 Homo sapiens (Human) TR35773_c0_g1_i2 Q86XL3 ANKL2_HUMAN 3.00E-58 GO:0051301; GO:0030176; GO:0007067; GO:0007084; GO:0042326; GO:0035307; GO:0051721; GO:0008601 Q19848 cell division; integral to endoplasmic reticulum membrane; mitosis; mitotic nuclear envelope reassembly; negative regulation of phosphorylation; positive regulation of protein dephosphorylation; protein phosphatase 2A binding; protein phosphatase type 2A regulator activity IPR002110; IPR020683; IPR011015; IPR003887; IPR011320; Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) ANKLE2 KIAA0692 LEM4 Homo sapiens (Human) TR35773_c0_g1_i3 Q6P1H6 ANKL2_MOUSE 7.00E-57 GO:0051301; GO:0030176; GO:0007067; GO:0007084; GO:0042326; GO:0035307; GO:0051721 cell division; integral to endoplasmic reticulum membrane; mitosis; mitotic nuclear envelope reassembly; negative regulation of phosphorylation; positive regulation of protein dephosphorylation; protein phosphatase 2A binding IPR002110; IPR020683; IPR011015; IPR003887; Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) Ankle2 D5Ertd585e Kiaa0692 Lem4 Mus musculus (Mouse) TR35773_c0_g1_i4 Q86XL3 ANKL2_HUMAN 3.00E-34 GO:0051301; GO:0030176; GO:0007067; GO:0007084; GO:0042326; GO:0035307; GO:0051721; GO:0008601 Q19848 cell division; integral to endoplasmic reticulum membrane; mitosis; mitotic nuclear envelope reassembly; negative regulation of phosphorylation; positive regulation of protein dephosphorylation; protein phosphatase 2A binding; protein phosphatase type 2A regulator activity IPR002110; IPR020683; IPR011015; IPR003887; IPR011320; Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) ANKLE2 KIAA0692 LEM4 Homo sapiens (Human) TR35776_c1_g1_i1 Q6DCP1 FXRD1_XENLA 1.00E-105 GO:0016021; GO:0016491 integral to membrane; oxidoreductase activity IPR006076; FAD-dependent oxidoreductase domain-containing protein 1 (EC 1.-.-.-) foxred1 Xenopus laevis (African clawed frog) TR35777_c3_g2_i1 Q9WVS6 PRKN2_MOUSE 1.00E-107 GO:0008344; GO:0006914; GO:0030054; GO:0005829; GO:0030425; GO:0042417; GO:0051583; GO:0005783; GO:0007612; GO:0005739; GO:0070997; GO:0043005; GO:0042415; GO:0005634; GO:0014069; GO:0045211; GO:0070936; GO:0043234; GO:0006513; GO:0010506; GO:0046928; GO:0001964; GO:0035249; GO:0006511; GO:0004842; GO:0008270 Q9ERU9; P68510; Q3U133 "adult locomotory behavior; autophagy; cell junction; cytosol; dendrite; dopamine metabolic process; dopamine uptake involved in synaptic transmission; endoplasmic reticulum; learning; mitochondrion; neuron death; neuron projection; norepinephrine metabolic process; nucleus; postsynaptic density; postsynaptic membrane; protein K48-linked ubiquitination; protein complex; protein monoubiquitination; regulation of autophagy; regulation of neurotransmitter secretion; startle response; synaptic transmission, glutamatergic; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding" IPR003977; IPR000626; IPR002867; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase parkin (EC 6.3.2.-) Park2 Prkn Mus musculus (Mouse) TR35779_c0_g1_i1 Q7T0W5 TFB1M_XENLA 5.00E-114 GO:0003677; GO:0005739; GO:0000179; GO:0031167; GO:0006355; GO:0006351 "DNA binding; mitochondrion; rRNA (adenine-N6,N6-)-dimethyltransferase activity; rRNA methylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR023165; IPR001737; IPR020598; "Dimethyladenosine transferase 1, mitochondrial (EC 2.1.1.-) (Mitochondrial 12S rRNA dimethylase 1) (Mitochondrial transcription factor B1) (mtTFB1) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1)" tfb1m Xenopus laevis (African clawed frog) TR35779_c0_g1_i2 Q28HM1 TFB1M_XENTR 3.00E-111 GO:0003677; GO:0005739; GO:0000179; GO:0031167; GO:0006355; GO:0006351 "DNA binding; mitochondrion; rRNA (adenine-N6,N6-)-dimethyltransferase activity; rRNA methylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR023165; IPR001737; IPR020598; "Dimethyladenosine transferase 1, mitochondrial (EC 2.1.1.-) (Mitochondrial 12S rRNA dimethylase 1) (Mitochondrial transcription factor B1) (mtTFB1) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1)" tfb1m TTpA018f13.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35779_c0_g1_i3 Q7T0W5 TFB1M_XENLA 1.00E-70 GO:0003677; GO:0005739; GO:0000179; GO:0031167; GO:0006355; GO:0006351 "DNA binding; mitochondrion; rRNA (adenine-N6,N6-)-dimethyltransferase activity; rRNA methylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR023165; IPR001737; IPR020598; "Dimethyladenosine transferase 1, mitochondrial (EC 2.1.1.-) (Mitochondrial 12S rRNA dimethylase 1) (Mitochondrial transcription factor B1) (mtTFB1) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1)" tfb1m Xenopus laevis (African clawed frog) TR3578_c0_g1_i1 A8ABM5 EF1A_IGNH4 1.00E-20 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; translation elongation factor activity IPR000795; IPR027417; IPR005225; IPR009000; IPR009001; IPR004539; IPR004161; IPR004160; Elongation factor 1-alpha (EF-1-alpha) (Elongation factor Tu) (EF-Tu) tuf Igni_1150 Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) TR35780_c0_g3_i1 Q7TSK7 ATL2_MOUSE 4.00E-08 GO:0004222; GO:0005578; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; zinc ion binding IPR010294; IPR013273; IPR010909; IPR000884; ADAMTS-like protein 2 (ADAMTSL-2) (TSP1-repeat-containing protein 1) (TCP-1) Adamtsl2 Kiaa0605 Tcp1 Mus musculus (Mouse) TR35780_c0_g3_i2 Q96RW7 HMCN1_HUMAN 4.00E-91 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR35780_c0_g3_i3 P59509 ATS19_MOUSE 7.00E-13 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 19 (ADAM-TS 19) (ADAM-TS19) (ADAMTS-19) (EC 3.4.24.-) Adamts19 Mus musculus (Mouse) TR35780_c0_g3_i7 P57110 ATS8_MOUSE 3.00E-13 GO:0008201; GO:0004222; GO:0005578; GO:0006508; GO:0008270 heparin binding; metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR013277; IPR001590; IPR013273; IPR002870; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAM-TS 8) (ADAM-TS8) (ADAMTS-8) (EC 3.4.24.-) (METH-2) Adamts8 Mus musculus (Mouse) TR35781_c1_g3_i1 Q26626 KIFA3_STRPU 0 GO:0016939; GO:0007017 kinesin II complex; microtubule-based process IPR011989; IPR016024; IPR000225; IPR008658; Kinesin-associated protein 3 (SpKAP115) KAP115 Strongylocentrotus purpuratus (Purple sea urchin) TR35784_c0_g1_i1 Q9Y6I4 UBP3_HUMAN 6.00E-170 GO:0006281; GO:0016578; GO:0000278; GO:0000790; GO:0031647; GO:0004221; GO:0006511; GO:0004843; GO:0008270 DNA repair; histone deubiquitination; mitotic cell cycle; nuclear chromatin; regulation of protein stability; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity; zinc ion binding IPR018200; IPR001394; IPR013083; IPR001607; Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) USP3 Homo sapiens (Human) TR35784_c0_g1_i2 Q8C2S0 UBP44_MOUSE 5.00E-13 GO:0051301; GO:0008234; GO:0007067; GO:0005634; GO:0043161; GO:0090266; GO:0004221; GO:0008270 cell division; cysteine-type peptidase activity; mitosis; nucleus; proteasomal ubiquitin-dependent protein catabolic process; regulation of mitotic cell cycle spindle assembly checkpoint; ubiquitin thiolesterase activity; zinc ion binding IPR018200; IPR001394; IPR013083; IPR001607; Ubiquitin carboxyl-terminal hydrolase 44 (EC 3.4.19.12) (Deubiquitinating enzyme 44) (Ubiquitin thioesterase 44) (Ubiquitin-specific-processing protease 44) Usp44 Mus musculus (Mouse) TR35785_c0_g3_i2 Q8MJU1 CASP3_FELCA 6.00E-25 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Felis catus (Cat) (Felis silvestris catus) TR35785_c0_g3_i3 P55214 CASP7_MESAU 3.00E-26 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR015471; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; "Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11; Caspase-7, N-terminally processed]" CASP7 MCH3 Mesocricetus auratus (Golden hamster) TR35787_c1_g1_i1 Q9NBX4 RTXE_DROME 6.00E-06 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR35788_c0_g1_i2 O35796 C1QBP_RAT 7.00E-34 GO:0008380; GO:0031690; GO:0006915; GO:0009986; GO:0006958; GO:0001849; GO:0005737; GO:0005829; GO:0005615; GO:0005540; GO:0006955; GO:0045087; GO:0030984; GO:0003729; GO:0006397; GO:0042256; GO:0005759; GO:0097177; GO:0039534; GO:0039536; GO:0050687; GO:0032689; GO:0032695; GO:0048025; GO:0000122; GO:0005730; GO:0005634; GO:0014065; GO:0005886; GO:0043065; GO:2000510; GO:0070131; GO:0090023; GO:0051897; GO:1900026; GO:1901165; GO:0005080; GO:0030449; GO:0003714; GO:0006351 P18841 "RNA splicing; adrenergic receptor binding; apoptotic process; cell surface; complement activation, classical pathway; complement component C1q binding; cytoplasm; cytosol; extracellular space; hyaluronic acid binding; immune response; innate immune response; kininogen binding; mRNA binding; mRNA processing; mature ribosome assembly; mitochondrial matrix; mitochondrial ribosome binding; negative regulation of MDA-5 signaling pathway; negative regulation of RIG-I signaling pathway; negative regulation of defense response to virus; negative regulation of interferon-gamma production; negative regulation of interleukin-12 production; negative regulation of mRNA splicing, via spliceosome; negative regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; phosphatidylinositol 3-kinase cascade; plasma membrane; positive regulation of apoptotic process; positive regulation of dendritic cell chemotaxis; positive regulation of mitochondrial translation; positive regulation of neutrophil chemotaxis; positive regulation of protein kinase B signaling cascade; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of trophoblast cell migration; protein kinase C binding; regulation of complement activation; transcription corepressor activity; transcription, DNA-dependent" IPR003428; "Complement component 1 Q subcomponent-binding protein, mitochondrial (GC1q-R protein) (Glycoprotein gC1qBP) (C1qBP)" C1qbp Gc1qbp Rattus norvegicus (Rat) TR35791_c2_g1_i2 Q9UHC3 ASIC3_HUMAN 7.00E-07 GO:0005737; GO:0050968; GO:0050966; GO:0050965; GO:0042931; GO:0005887; GO:0015280; GO:0001101; GO:0009408; GO:0007600; GO:0007165; GO:0005272 cytoplasm; detection of chemical stimulus involved in sensory perception of pain; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; enterobactin transporter activity; integral to plasma membrane; ligand-gated sodium channel activity; response to acid; response to heat; sensory perception; signal transduction; sodium channel activity IPR004724; IPR001873; IPR020903; Acid-sensing ion channel 3 (ASIC3) (hASIC3) (Amiloride-sensitive cation channel 3) (Neuronal amiloride-sensitive cation channel 3) (Testis sodium channel 1) (hTNaC1) ASIC3 ACCN3 SLNAC1 TNAC1 Homo sapiens (Human) TR35791_c4_g2_i1 Q9DC07 LNEBL_MOUSE 3.00E-56 GO:0005737; GO:0008270 cytoplasm; zinc ion binding IPR000900; IPR001452; IPR001781; LIM zinc-binding domain-containing Nebulette (Actin-binding Z-disk protein) Nebl Lnebl Mus musculus (Mouse) TR35791_c4_g2_i12 Q9DC07 LNEBL_MOUSE 6.00E-45 GO:0005737; GO:0008270 cytoplasm; zinc ion binding IPR000900; IPR001452; IPR001781; LIM zinc-binding domain-containing Nebulette (Actin-binding Z-disk protein) Nebl Lnebl Mus musculus (Mouse) TR35791_c4_g2_i13 Q8I7C3 LASP1_DROME 3.00E-52 GO:0003779; GO:0005925; GO:0007279; GO:0045856; GO:0007291; GO:0070864; GO:0008270 actin binding; focal adhesion; pole cell formation; positive regulation of pole plasm oskar mRNA localization; sperm individualization; sperm individualization complex; zinc ion binding IPR000900; IPR001452; IPR001781; LIM and SH3 domain protein Lasp Lasp CG3849 Drosophila melanogaster (Fruit fly) TR35791_c4_g2_i3 Q8I7C3 LASP1_DROME 2.00E-53 GO:0003779; GO:0005925; GO:0007279; GO:0045856; GO:0007291; GO:0070864; GO:0008270 actin binding; focal adhesion; pole cell formation; positive regulation of pole plasm oskar mRNA localization; sperm individualization; sperm individualization complex; zinc ion binding IPR000900; IPR001452; IPR001781; LIM and SH3 domain protein Lasp Lasp CG3849 Drosophila melanogaster (Fruit fly) TR35791_c4_g2_i5 P34416 LASP1_CAEEL 6.00E-71 GO:0030054; GO:0055120; GO:0008270 cell junction; striated muscle dense body; zinc ion binding IPR000900; IPR000108; IPR001452; IPR001781; LIM and SH3 domain protein F42H10.3 F42H10.3 Caenorhabditis elegans TR35791_c4_g2_i8 P34416 LASP1_CAEEL 5.00E-70 GO:0030054; GO:0055120; GO:0008270 cell junction; striated muscle dense body; zinc ion binding IPR000900; IPR000108; IPR001452; IPR001781; LIM and SH3 domain protein F42H10.3 F42H10.3 Caenorhabditis elegans TR35791_c4_g2_i9 Q8I7C3 LASP1_DROME 1.00E-52 GO:0003779; GO:0005925; GO:0007279; GO:0045856; GO:0007291; GO:0070864; GO:0008270 actin binding; focal adhesion; pole cell formation; positive regulation of pole plasm oskar mRNA localization; sperm individualization; sperm individualization complex; zinc ion binding IPR000900; IPR001452; IPR001781; LIM and SH3 domain protein Lasp Lasp CG3849 Drosophila melanogaster (Fruit fly) TR35792_c4_g1_i3 P24367 PPIB_CHICK 9.00E-70 GO:0005788; GO:0042277; GO:0003755; GO:0006457; GO:0000413 endoplasmic reticulum lumen; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB Gallus gallus (Chicken) TR35792_c4_g1_i7 P52014 CYP6_CAEEL 8.00E-63 GO:0003755; GO:0006457; GO:0000413 peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase 6 (PPIase 6) (EC 5.2.1.8) (Cyclophilin-6) (Rotamase 6) cyn-6 cyp-6 F42G9.2 Caenorhabditis elegans TR35792_c4_g1_i8 P23284 PPIB_HUMAN 2.00E-22 GO:0005788; GO:0030198; GO:0042470; GO:0042277; GO:0003755; GO:0006457; GO:0051082 endoplasmic reticulum lumen; extracellular matrix organization; melanosome; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein folding; unfolded protein binding IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB CYPB Homo sapiens (Human) TR35793_c1_g1_i1 A8E4S7 MB213_DANRE 2.00E-07 IPR024810; Protein mab-21-like 3 mab21L3 si:ch211-246m4.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR35795_c1_g1_i1 F6V515 MTAP_XENTR 4.00E-111 GO:0019509; GO:0017061; GO:0005737; GO:0005634; GO:0004645; GO:0006166 L-methionine salvage from methylthioadenosine; S-methyl-5-thioadenosine phosphorylase activity; cytoplasm; nucleus; phosphorylase activity; purine ribonucleoside salvage IPR010044; IPR000845; IPR001369; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1. S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase) mtap Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35795_c1_g1_i3 Q7ZV22 MTAP_DANRE 1.00E-114 GO:0019509; GO:0017061; GO:0005737; GO:0005634; GO:0004645; GO:0006166 L-methionine salvage from methylthioadenosine; S-methyl-5-thioadenosine phosphorylase activity; cytoplasm; nucleus; phosphorylase activity; purine ribonucleoside salvage IPR010044; IPR000845; IPR001369; IPR018099; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1. S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase) mtap zgc:66012 Danio rerio (Zebrafish) (Brachydanio rerio) TR35796_c2_g1_i3 Q99572 P2RX7_HUMAN 2.00E-06 GO:0005524; GO:0043132; GO:0043029; GO:0042098; GO:0000187; GO:0097190; GO:0032059; GO:0032060; GO:0000902; GO:0006884; GO:0005911; GO:0031668; GO:0046513; GO:0032963; GO:0005507; GO:0019835; GO:0005737; GO:0050830; GO:0009897; GO:0004931; GO:0048873; GO:0006954; GO:0045087; GO:0005639; GO:0005887; GO:0001530; GO:0000287; GO:0006900; GO:0051899; GO:0006509; GO:0045121; GO:0007005; GO:0044254; GO:0043409; GO:0045779; GO:0031594; GO:0043025; GO:0035872; GO:0001845; GO:0006649; GO:0045332; GO:0007009; GO:0046931; GO:0001916; GO:0043065; GO:0030501; GO:0010524; GO:0045919; GO:0051495; GO:0014054; GO:0014049; GO:0050717; GO:0050718; GO:0032755; GO:0051901; GO:0032308; GO:0043234; GO:0042803; GO:0051259; GO:0006468; GO:0016485; GO:0001614; GO:0072593; GO:0005102; GO:0019228; GO:0051709; GO:0002028; GO:0051209; GO:0033198; GO:0051592; GO:0042493; GO:0051602; GO:0034405; GO:0032496; GO:0009612; GO:0010043; GO:0019233; GO:0048705; GO:0016079; GO:0043195; GO:0008270 P00519; P62993; P16333 "ATP binding; NAD transport; T cell homeostasis; T cell proliferation; activation of MAPK activity; apoptotic signaling pathway; bleb; bleb assembly; cell morphogenesis; cell volume homeostasis; cell-cell junction; cellular response to extracellular stimulus; ceramide biosynthetic process; collagen metabolic process; copper ion binding; cytolysis; cytoplasm; defense response to Gram-positive bacterium; external side of plasma membrane; extracellular ATP-gated cation channel activity; homeostasis of number of cells within a tissue; inflammatory response; innate immune response; integral to nuclear inner membrane; integral to plasma membrane; lipopolysaccharide binding; magnesium ion binding; membrane budding; membrane depolarization; membrane protein ectodomain proteolysis; membrane raft; mitochondrion organization; multicellular organismal protein catabolic process; negative regulation of MAPK cascade; negative regulation of bone resorption; neuromuscular junction; neuronal cell body; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; phagolysosome assembly; phospholipid transfer to membrane; phospholipid translocation; plasma membrane organization; pore complex assembly; positive regulation of T cell mediated cytotoxicity; positive regulation of apoptotic process; positive regulation of bone mineralization; positive regulation of calcium ion transport into cytosol; positive regulation of cytolysis; positive regulation of cytoskeleton organization; positive regulation of gamma-aminobutyric acid secretion; positive regulation of glutamate secretion; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 production; positive regulation of mitochondrial depolarization; positive regulation of prostaglandin secretion; protein complex; protein homodimerization activity; protein oligomerization; protein phosphorylation; protein processing; purinergic nucleotide receptor activity; reactive oxygen species metabolic process; receptor binding; regulation of action potential in neuron; regulation of killing of cells of other organism; regulation of sodium ion transport; release of sequestered calcium ion into cytosol; response to ATP; response to calcium ion; response to drug; response to electrical stimulus; response to fluid shear stress; response to lipopolysaccharide; response to mechanical stimulus; response to zinc ion; sensory perception of pain; skeletal system morphogenesis; synaptic vesicle exocytosis; terminal bouton; zinc ion binding" IPR003050; IPR027309; IPR001429; P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2RX7 Homo sapiens (Human) TR35797_c0_g1_i1 Q5RBH8 ITFG2_PONAB 7.00E-135 IPR013517; IPR017986; Integrin-alpha FG-GAP repeat-containing protein 2 ITFG2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35798_c0_g1_i1 F1RAX8 COQ6_DANRE 2.00E-156 GO:0005794; GO:0042995; GO:0050660; GO:0016709; GO:0006744 "Golgi apparatus; cell projection; flavin adenine dinucleotide binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; ubiquinone biosynthetic process" IPR002938; IPR003042; IPR018168; IPR010971; IPR000689; Cofactor biosynthesis; ubiquinone biosynthesis. Ubiquinone biosynthesis monooxygenase COQ6 (EC 1.14.13.-) (Coenzyme Q10 monooxygenase 6) coq6 Danio rerio (Zebrafish) (Brachydanio rerio) TR35798_c0_g1_i2 Q9Y2Z9 COQ6_HUMAN 2.00E-129 GO:0005794; GO:0042995; GO:0050660; GO:0005739; GO:0016709; GO:0006744 "Golgi apparatus; cell projection; flavin adenine dinucleotide binding; mitochondrion; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; ubiquinone biosynthetic process" IPR002938; IPR003042; IPR018168; IPR010971; IPR000689; Cofactor biosynthesis; ubiquinone biosynthesis. Ubiquinone biosynthesis monooxygenase COQ6 (EC 1.14.13.-) (Coenzyme Q10 monooxygenase 6) COQ6 CGI-10 Homo sapiens (Human) TR35799_c4_g1_i1 Q10914 GLR2_CAEEL 9.00E-54 GO:0030054; GO:0005234; GO:0016021; GO:0004970; GO:0035235; GO:0045211 cell junction; extracellular-glutamate-gated ion channel activity; integral to membrane; ionotropic glutamate receptor activity; ionotropic glutamate receptor signaling pathway; postsynaptic membrane IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; Glutamate receptor 2 glr-2 B0280.12/K04G7.2 Caenorhabditis elegans TR35799_c4_g1_i2 P23819 GRIA2_MOUSE 2.00E-50 GO:0004971; GO:0032281; GO:0030054; GO:0005783; GO:0005789; GO:0005234; GO:0015277; GO:0043005; GO:0045211; GO:0007268; GO:0008021 Q8VHY0; P23818; Q925T6 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; cell junction; endoplasmic reticulum; endoplasmic reticulum membrane; extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity; neuron projection; postsynaptic membrane; synaptic transmission; synaptic vesicle IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; "Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (GluA2)" Gria2 Glur2 Mus musculus (Mouse) TR35799_c4_g1_i4 Q91756 GLRK_XENLA 3.00E-50 GO:0030054; GO:0005234; GO:0016021; GO:0004970; GO:0035235; GO:0045211 cell junction; extracellular-glutamate-gated ion channel activity; integral to membrane; ionotropic glutamate receptor activity; ionotropic glutamate receptor signaling pathway; postsynaptic membrane IPR019594; IPR001320; IPR001508; IPR001638; Glutamate receptor U1 (Kainate-binding protein) (Unitary non-NMDA glutamate receptor subunit 1) (XENU1) kbp Xenopus laevis (African clawed frog) TR35800_c0_g1_i1 Q5ZJ85 PRPF3_CHICK 0 GO:0046540; GO:0000398; GO:0016607; GO:0005681 "U4/U6 x U5 tri-snRNP complex; mRNA splicing, via spliceosome; nuclear speck; spliceosomal complex" IPR010541; IPR013881; IPR027104; IPR002483; U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) PRPF3 RCJMB04_20b24 Gallus gallus (Chicken) TR35801_c0_g1_i3 Q92113 CP17A_SQUAC 3.00E-92 GO:0047442; GO:0020037; GO:0005506; GO:0016020; GO:0004508; GO:0006694 17-alpha-hydroxyprogesterone aldolase activity; heme binding; iron ion binding; membrane; steroid 17-alpha-monooxygenase activity; steroid biosynthetic process IPR001128; IPR017972; IPR002401; Lipid metabolism; steroid biosynthesis. "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.99.9) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Squalus acanthias (Spiny dogfish) TR35801_c0_g1_i4 Q6YTF1 C76M8_ORYSJ 1.00E-28 GO:0016102; GO:0036202; GO:0020037; GO:0016021; GO:0005506 "diterpenoid biosynthetic process; ent-cassa-12,15-diene 11-hydroxylase activity; heme binding; integral to membrane; iron ion binding" IPR001128; IPR017972; IPR002401; Ent-cassadiene C11-alpha-hydroxylase 2 (EC 1.14.13.145) (Cytochrome P450 76M8) CYP76M8 Os02g0569400 LOC_Os02g36070 OsJ_07203 OSJNBa0008E01.2 P0025F02.31 Oryza sativa subsp. japonica (Rice) TR35801_c0_g1_i5 Q9VG17 CP304_DROME 3.00E-39 GO:0005789; GO:0020037; GO:0005506; GO:0004497; GO:0016705 "endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Probable cytochrome P450 304a1 (EC 1.14.-.-) (CYPCCCIVA1) Cyp304a1 CG7241 Drosophila melanogaster (Fruit fly) TR35802_c1_g1_i1 Q24742 TRX_DROVI 3.00E-96 GO:0042800; GO:0035097; GO:0007275; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "histone methyltransferase activity (H3-K4 specific); histone methyltransferase complex; multicellular organismal development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR003889; IPR003888; IPR015722; IPR016569; IPR003616; IPR001214; IPR011011; IPR001628; IPR001965; IPR019787; IPR001841; IPR013083; Histone-lysine N-methyltransferase trithorax (EC 2.1.1.43) trx Drosophila virilis (Fruit fly) TR35802_c1_g1_i2 P55200 MLL1_MOUSE 4.00E-133 GO:0006306; GO:0071339; GO:0009952; GO:0003682; GO:0035162; GO:0043984; GO:0070577; GO:0042800; GO:0008285; GO:0045944; GO:0051569; GO:0006351; GO:0045322; GO:0008270 "DNA methylation; MLL1 complex; anterior/posterior pattern specification; chromatin binding; embryonic hemopoiesis; histone H4-K16 acetylation; histone acetyl-lysine binding; histone methyltransferase activity (H3-K4 specific); negative regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of histone H3-K4 methylation; transcription, DNA-dependent; unmethylated CpG binding; zinc ion binding" IPR017956; IPR001487; IPR003889; IPR003888; IPR016569; IPR003616; IPR001214; IPR002857; IPR011011; IPR001965; IPR019787; IPR013083; Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.43) (ALL-1) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Kmt2a All1 Hrx Mll Mll1 Mus musculus (Mouse) TR35804_c0_g1_i1 D4A666 UBN2_RAT 1.00E-35 GO:0005634 nucleus IPR014840; IPR026943; IPR026949; IPR026947; Ubinuclein-2 Ubn2 Rattus norvegicus (Rat) TR35804_c0_g1_i4 Q6ZU65 UBN2_HUMAN 5.00E-33 GO:0005634 nucleus IPR014840; IPR026943; IPR026949; IPR026947; Ubinuclein-2 UBN2 KIAA2030 Homo sapiens (Human) TR35804_c0_g1_i5 D4A666 UBN2_RAT 1.00E-35 GO:0005634 nucleus IPR014840; IPR026943; IPR026949; IPR026947; Ubinuclein-2 Ubn2 Rattus norvegicus (Rat) TR35806_c0_g1_i1 Q61089 FZD6_MOUSE 1.00E-11 GO:0004930; GO:0007199; GO:0030165; GO:0060071; GO:0042813; GO:0001525; GO:0045177; GO:0016327; GO:0007409; GO:0060070; GO:0033278; GO:0005737; GO:0001736; GO:0008406; GO:0001942; GO:0042472; GO:0016021; GO:0090090; GO:0043433; GO:0001843; GO:0032589; GO:0030168; GO:0006357 "G-protein coupled receptor activity; G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; PDZ domain binding; Wnt receptor signaling pathway, planar cell polarity pathway; Wnt-activated receptor activity; angiogenesis; apical part of cell; apicolateral plasma membrane; axonogenesis; canonical Wnt receptor signaling pathway; cell proliferation in midbrain; cytoplasm; establishment of planar polarity; gonad development; hair follicle development; inner ear morphogenesis; integral to membrane; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of sequence-specific DNA binding transcription factor activity; neural tube closure; neuron projection membrane; platelet activation; regulation of transcription from RNA polymerase II promoter" IPR000539; IPR015526; IPR020067; IPR026543; IPR017981; Frizzled-6 (Fz-6) (mFz6) Fzd6 Mus musculus (Mouse) TR35806_c0_g1_i2 Q8K480 MFRP_MOUSE 1.00E-08 GO:0016021 integral to membrane IPR000859; IPR020067; IPR023415; IPR002172; Membrane frizzled-related protein (Membrane-type frizzled-related protein) Mfrp Mus musculus (Mouse) TR35806_c0_g1_i3 Q61090 FZD7_MOUSE 1.00E-16 GO:0004930; GO:0007199; GO:0030165; GO:0033077; GO:0007223; GO:0042813; GO:0045177; GO:0007409; GO:0007420; GO:0060070; GO:0005737; GO:0009790; GO:0030855; GO:0008406; GO:0016021; GO:0060231; GO:0010812; GO:0042666; GO:0032589; GO:0038031; GO:0060054; GO:0042327; GO:0045893; GO:0035412; GO:0006357; GO:0014834; GO:0048103; GO:0034446; GO:0001944 Q62108 "G-protein coupled receptor activity; G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; PDZ domain binding; T cell differentiation in thymus; Wnt receptor signaling pathway, calcium modulating pathway; Wnt-activated receptor activity; apical part of cell; axonogenesis; brain development; canonical Wnt receptor signaling pathway; cytoplasm; embryo development; epithelial cell differentiation; gonad development; integral to membrane; mesenchymal to epithelial transition; negative regulation of cell-substrate adhesion; negative regulation of ectodermal cell fate specification; neuron projection membrane; non-canonical Wnt receptor signaling pathway via JNK cascade; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of phosphorylation; positive regulation of transcription, DNA-dependent; regulation of catenin import into nucleus; regulation of transcription from RNA polymerase II promoter; satellite cell maintenance involved in skeletal muscle regeneration; somatic stem cell division; substrate adhesion-dependent cell spreading; vasculature development" IPR000539; IPR015526; IPR020067; IPR026552; IPR017981; Frizzled-7 (Fz-7) (mFz7) Fzd7 Mus musculus (Mouse) TR35806_c0_g1_i4 Q9PUU6 FZD2_XENLA 1.00E-15 GO:0004930; GO:0016055; GO:0042813; GO:0016021; GO:0007275; GO:0005886 G-protein coupled receptor activity; Wnt receptor signaling pathway; Wnt-activated receptor activity; integral to membrane; multicellular organismal development; plasma membrane IPR000539; IPR015526; IPR020067; IPR026550; IPR017981; Frizzled-2 (Fz-2) (Xfz2) fzd2 fz2 Xenopus laevis (African clawed frog) TR35808_c2_g2_i1 Q6GP15 MED25_XENLA 1.00E-59 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR021394; IPR021406; IPR021397; IPR021419; IPR002035; Mediator of RNA polymerase II transcription subunit 25 (Mediator complex subunit 25) med25 Xenopus laevis (African clawed frog) TR35808_c2_g2_i2 A4IHD9 MED25_XENTR 2.00E-61 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR021394; IPR021406; IPR021397; IPR021419; IPR002035; Mediator of RNA polymerase II transcription subunit 25 (Mediator complex subunit 25) med25 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR3581_c1_g1_i1 O75592 MYCB2_HUMAN 1.00E-16 GO:0030424; GO:0021785; GO:0021952; GO:0015630; GO:0005634; GO:0051493; GO:0032880; GO:0006355; GO:0006351; GO:0004842; GO:0008270 Q99IB8 "axon; branchiomotor neuron axon guidance; central nervous system projection neuron axonogenesis; microtubule cytoskeleton; nucleus; regulation of cytoskeleton organization; regulation of protein localization; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR004939; IPR017868; IPR008979; IPR027047; IPR013783; IPR014756; IPR012983; IPR009091; IPR000408; IPR003646; IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc) MYCBP2 KIAA0916 PAM Homo sapiens (Human) TR35812_c0_g1_i2 A0LMC1 PHNX_SYNFM 1.00E-65 GO:0000287; GO:0019700; GO:0050194 magnesium ion binding; organic phosphonate catabolic process; phosphonoacetaldehyde hydrolase activity IPR023214; IPR023198; IPR006323; Phosphonoacetaldehyde hydrolase (Phosphonatase) (EC 3.11.1.1) (Phosphonoacetaldehyde phosphonohydrolase) phnX Sfum_2896 Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB) TR35812_c0_g1_i3 A0LMC1 PHNX_SYNFM 1.00E-65 GO:0000287; GO:0019700; GO:0050194 magnesium ion binding; organic phosphonate catabolic process; phosphonoacetaldehyde hydrolase activity IPR023214; IPR023198; IPR006323; Phosphonoacetaldehyde hydrolase (Phosphonatase) (EC 3.11.1.1) (Phosphonoacetaldehyde phosphonohydrolase) phnX Sfum_2896 Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB) TR35813_c0_g1_i1 Q5PXY7 RABP2_BOVIN 5.00E-11 GO:0005737; GO:0005783; GO:0005634; GO:0016918; GO:0019841; GO:0005215 cytoplasm; endoplasmic reticulum; nucleus; retinal binding; retinol binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II) CRABP2 Bos taurus (Bovine) TR35813_c0_g1_i3 O76821 FABP_ACASI 6.00E-11 GO:0005737; GO:0008289; GO:0005215 cytoplasm; lipid binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; Fatty acid-binding protein (allergen Aca s 13) (Fragment) Acarus siro (Flour mite) (Tyroglyphus farinae) TR35815_c3_g1_i1 P32314 FOXN2_HUMAN 1.00E-11 GO:0005634; GO:0043565; GO:0003700; GO:0035914; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; skeletal muscle cell differentiation; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; Forkhead box protein N2 (Human T-cell leukemia virus enhancer factor) FOXN2 HTLF Homo sapiens (Human) TR35815_c5_g1_i2 Q5ZMD4 TRI59_CHICK 9.00E-06 GO:0016021; GO:0005622; GO:0008270 integral to membrane; intracellular; zinc ion binding IPR000315; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 59 TRIM59 RCJMB04_2h17 Gallus gallus (Chicken) TR35815_c5_g1_i6 Q80VI1 TRI56_MOUSE 1.00E-18 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) TR35817_c0_g1_i1 Q8K339 KIN17_MOUSE 6.00E-145 GO:0006310; GO:0006281; GO:0006260; GO:0003723; GO:0005737; GO:0003690; GO:0006397; GO:0046872; GO:0016363; GO:0006974 DNA recombination; DNA repair; DNA replication; RNA binding; cytoplasm; double-stranded DNA binding; mRNA processing; metal ion binding; nuclear matrix; response to DNA damage stimulus IPR019447; IPR005824; IPR015880; "DNA/RNA-binding protein KIN17 (Binding to curved DNA) (KIN, antigenic determinant of recA protein)" Kin Btcd Kin17 Mus musculus (Mouse) TR35817_c0_g1_i4 Q9Y7X9 KIN17_SCHPO 3.00E-58 GO:0006261; GO:0005737; GO:0046872; GO:0005730 DNA-dependent DNA replication; cytoplasm; metal ion binding; nucleolus IPR019447; IPR007087; KIN17-like protein SPBC365.09c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR35819_c2_g1_i6 Q2QDF1 DNSL1_CHLAE 3.00E-58 GO:0006308; GO:0016888; GO:0005783; GO:0090305 "DNA catabolic process; endodeoxyribonuclease activity, producing 5'-phosphomonoesters; endoplasmic reticulum; nucleic acid phosphodiester bond hydrolysis" IPR018057; IPR016202; IPR005135; Deoxyribonuclease-1-like 1 (EC 3.1.21.-) (DNase X) (Deoxyribonuclease I-like 1) (DNase I-like 1) DNASE1L1 Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) TR35819_c2_g1_i8 Q9D1G0 DNSL2_MOUSE 5.00E-42 GO:0006308; GO:0016888; GO:0005576; GO:0090305 "DNA catabolic process; endodeoxyribonuclease activity, producing 5'-phosphomonoesters; extracellular region; nucleic acid phosphodiester bond hydrolysis" IPR018057; IPR016202; IPR005135; Deoxyribonuclease-1-like 2 (EC 3.1.21.-) (Deoxyribonuclease I-like 2) (DNase I-like 2) Dnase1l2 Mus musculus (Mouse) TR35820_c3_g2_i1 Q9WU61 CLCC1_RAT 6.00E-28 GO:0005794; GO:0005254; GO:0005783; GO:0016021; GO:0005634 Golgi apparatus; chloride channel activity; endoplasmic reticulum; integral to membrane; nucleus IPR009231; Chloride channel CLIC-like protein 1 (Mid-1-related chloride channel protein 1) Clcc1 Mclc Rattus norvegicus (Rat) TR35821_c0_g2_i1 Q8WZ42 TITIN_HUMAN 3.00E-19 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR35821_c0_g2_i2 P02708 ACHA_HUMAN 1.00E-06 GO:0042166; GO:0015464; GO:0004889; GO:0005892; GO:0030054; GO:0009986; GO:0046716; GO:0031594; GO:0007528; GO:0050905; GO:0007274; GO:0070050; GO:0045211; GO:0019228; GO:0003009; GO:0048630 acetylcholine binding; acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; cell surface; muscle cell cellular homeostasis; neuromuscular junction; neuromuscular junction development; neuromuscular process; neuromuscular synaptic transmission; neuron cellular homeostasis; postsynaptic membrane; regulation of action potential in neuron; skeletal muscle contraction; skeletal muscle tissue growth IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha CHRNA1 ACHRA CHNRA Homo sapiens (Human) TR35821_c0_g3_i1 P43143 ACHA6_RAT 1.00E-16 GO:0004889; GO:0005892; GO:0030054; GO:0008144; GO:0045211; GO:0051291 acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; drug binding; postsynaptic membrane; protein heterooligomerization IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Acra6 Rattus norvegicus (Rat) TR35821_c0_g4_i1 P04757 ACHA3_RAT 3.00E-18 GO:0042166; GO:0015464; GO:0004889; GO:0005892; GO:0030054; GO:0030425; GO:0008144; GO:0007507; GO:0043025; GO:0014069; GO:0045211; GO:0051291; GO:0042493; GO:0010035; GO:0035094 acetylcholine binding; acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; dendrite; drug binding; heart development; neuronal cell body; postsynaptic density; postsynaptic membrane; protein heterooligomerization; response to drug; response to inorganic substance; response to nicotine IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-3 Chrna3 Acra3 Rattus norvegicus (Rat) TR35822_c0_g2_i1 Q5RBQ4 UBP46_PONAB 0 GO:0007610; GO:0016579; GO:0032228; GO:0004221; GO:0006511; GO:0004843 "behavior; protein deubiquitination; regulation of synaptic transmission, GABAergic; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity" IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) USP46 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35823_c0_g1_i1 A5PLK6 RGSL_HUMAN 2.00E-29 GO:0016021; GO:0038032 integral to membrane; termination of G-protein coupled receptor signaling pathway IPR016137; IPR000342; Regulator of G-protein signaling protein-like RGSL1 RGSL RGSL2 Homo sapiens (Human) TR35824_c4_g1_i1 O75094 SLIT3_HUMAN 3.00E-09 GO:0035385; GO:0061364; GO:0048846; GO:0005509; GO:0032870; GO:0005615; GO:0005739; GO:0050919; GO:0030308; GO:0008285; GO:0070100; GO:0010629; GO:0009887; GO:0051414 Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; calcium ion binding; cellular response to hormone stimulus; extracellular space; mitochondrion; negative chemotaxis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of chemokine-mediated signaling pathway; negative regulation of gene expression; organ morphogenesis; response to cortisol stimulus IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 3 protein (Slit-3) (Multiple epidermal growth factor-like domains protein 5) (Multiple EGF-like domains protein 5) SLIT3 KIAA0814 MEGF5 SLIL2 UNQ691/PRO1336 Homo sapiens (Human) TR35824_c4_g2_i10 O75094 SLIT3_HUMAN 2.00E-07 GO:0035385; GO:0061364; GO:0048846; GO:0005509; GO:0032870; GO:0005615; GO:0005739; GO:0050919; GO:0030308; GO:0008285; GO:0070100; GO:0010629; GO:0009887; GO:0051414 Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; calcium ion binding; cellular response to hormone stimulus; extracellular space; mitochondrion; negative chemotaxis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of chemokine-mediated signaling pathway; negative regulation of gene expression; organ morphogenesis; response to cortisol stimulus IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 3 protein (Slit-3) (Multiple epidermal growth factor-like domains protein 5) (Multiple EGF-like domains protein 5) SLIT3 KIAA0814 MEGF5 SLIL2 UNQ691/PRO1336 Homo sapiens (Human) TR35824_c4_g2_i4 Q9Z1P4 LGR5_MOUSE 2.00E-08 GO:0007186; GO:0005794; GO:0048839; GO:0005887; GO:0090263; GO:0032588; GO:0004888 G-protein coupled receptor signaling pathway; Golgi apparatus; inner ear development; integral to plasma membrane; positive regulation of canonical Wnt receptor signaling pathway; trans-Golgi network membrane; transmembrane signaling receptor activity IPR000276; IPR017452; IPR002131; IPR001611; IPR003591; IPR000372; IPR026906; Leucine-rich repeat-containing G-protein coupled receptor 5 (G-protein coupled receptor 49) (Orphan G-protein coupled receptor FEX) Lgr5 Fex Gpr49 Mus musculus (Mouse) TR35829_c0_g1_i1 Q07076 ANXA7_MOUSE 2.00E-131 GO:0005509; GO:0005544; GO:0008283; GO:0006874; GO:0009992; GO:0042584; GO:0005829; GO:0005789; GO:0007599; GO:0005635; GO:0005886; GO:0008360; GO:0009651; GO:0035176; GO:0031982 calcium ion binding; calcium-dependent phospholipid binding; cell proliferation; cellular calcium ion homeostasis; cellular water homeostasis; chromaffin granule membrane; cytosol; endoplasmic reticulum membrane; hemostasis; nuclear envelope; plasma membrane; regulation of cell shape; response to salt stress; social behavior; vesicle IPR001464; IPR018502; IPR018252; IPR013286; Annexin A7 (Annexin VII) (Annexin-7) (Synexin) Anxa7 Anx7 Mus musculus (Mouse) TR35834_c2_g2_i4 P34642 SRP09_CAEEL 3.00E-26 GO:0008312; GO:0006614; GO:0045900; GO:0005786 "7S RNA binding; SRP-dependent cotranslational protein targeting to membrane; negative regulation of translational elongation; signal recognition particle, endoplasmic reticulum targeting" IPR008832; IPR009018; Signal recognition particle 9 kDa protein (SRP9) ZK512.4 Caenorhabditis elegans TR35835_c5_g1_i1 Q6PFJ7 NSMA3_DANRE 5.00E-69 GO:0000139; GO:0005789; GO:0016021; GO:0046872; GO:0050290; GO:0004767 Golgi membrane; endoplasmic reticulum membrane; integral to membrane; metal ion binding; sphingomyelin phosphodiesterase D activity; sphingomyelin phosphodiesterase activity IPR024129; Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III) smpd4 zgc:66367 Danio rerio (Zebrafish) (Brachydanio rerio) TR35835_c5_g1_i7 Q5XHG1 NSMA3_XENLA 2.00E-33 GO:0000139; GO:0005789; GO:0016021; GO:0046872; GO:0050290; GO:0004767 Golgi membrane; endoplasmic reticulum membrane; integral to membrane; metal ion binding; sphingomyelin phosphodiesterase D activity; sphingomyelin phosphodiesterase activity IPR024129; Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III) smpd4 Xenopus laevis (African clawed frog) TR35836_c0_g1_i2 Q08093 CNN2_MOUSE 8.00E-29 GO:0031032; GO:0071260; GO:0030097; GO:0030336; GO:0050765; GO:0010628; GO:0032970; GO:0042127; GO:0001725; GO:0042060 actomyosin structure organization; cellular response to mechanical stimulus; hemopoiesis; negative regulation of cell migration; negative regulation of phagocytosis; positive regulation of gene expression; regulation of actin filament-based process; regulation of cell proliferation; stress fiber; wound healing IPR001997; IPR000557; IPR001715; IPR003096; "Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin)" Cnn2 Mus musculus (Mouse) TR35836_c0_g1_i3 Q24799 MYPH_ECHGR 6.00E-39 IPR000557; IPR001715; IPR003096; Myophilin Echinococcus granulosus TR35837_c3_g1_i4 O09012 PEX5_MOUSE 0 GO:0048468; GO:0021795; GO:0021895; GO:0005829; GO:0007029; GO:0006635; GO:0007006; GO:0050905; GO:0001764; GO:0005778; GO:0005052; GO:0040018; GO:0008022; GO:0016560; GO:0006625; GO:0000038 "cell development; cerebral cortex cell migration; cerebral cortex neuron differentiation; cytosol; endoplasmic reticulum organization; fatty acid beta-oxidation; mitochondrial membrane organization; neuromuscular process; neuron migration; peroxisomal membrane; peroxisome matrix targeting signal-1 binding; positive regulation of multicellular organism growth; protein C-terminus binding; protein import into peroxisome matrix, docking; protein targeting to peroxisome; very long-chain fatty acid metabolic process" IPR024111; IPR013026; IPR011990; IPR001440; IPR019734; Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (PXR1P) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) Pex5 Pxr1 Mus musculus (Mouse) TR35837_c3_g1_i6 O09012 PEX5_MOUSE 0 GO:0048468; GO:0021795; GO:0021895; GO:0005829; GO:0007029; GO:0006635; GO:0007006; GO:0050905; GO:0001764; GO:0005778; GO:0005052; GO:0040018; GO:0008022; GO:0016560; GO:0006625; GO:0000038 "cell development; cerebral cortex cell migration; cerebral cortex neuron differentiation; cytosol; endoplasmic reticulum organization; fatty acid beta-oxidation; mitochondrial membrane organization; neuromuscular process; neuron migration; peroxisomal membrane; peroxisome matrix targeting signal-1 binding; positive regulation of multicellular organism growth; protein C-terminus binding; protein import into peroxisome matrix, docking; protein targeting to peroxisome; very long-chain fatty acid metabolic process" IPR024111; IPR013026; IPR011990; IPR001440; IPR019734; Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (PXR1P) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) Pex5 Pxr1 Mus musculus (Mouse) TR35839_c0_g1_i1 Q80T91 MEG11_MOUSE 3.00E-07 GO:0016323; GO:0034109; GO:0016021; GO:0010842 basolateral plasma membrane; homotypic cell-cell adhesion; integral to membrane; retina layer formation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) TR35839_c0_g1_i3 P59222 SREC2_MOUSE 1.00E-12 GO:0007157; GO:0016021; GO:0005044 heterophilic cell-cell adhesion; integral to membrane; scavenger receptor activity IPR000742; IPR013032; IPR009030; Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) TR35840_c1_g1_i2 Q99NE9 PBX4_MOUSE 2.00E-06 GO:0001741; GO:0005634; GO:0045893; GO:0006357; GO:0043565; GO:0003700; GO:0006351 "XY body; nucleus; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001356; IPR009057; IPR005542; Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4) Pbx4 Mus musculus (Mouse) TR35841_c0_g1_i2 Q11118 WOS2_SCHPO 6.00E-20 GO:0007049; GO:0051087; GO:0005829; GO:0005634; GO:0032212; GO:0006457; GO:0007346 cell cycle; chaperone binding; cytosol; nucleus; positive regulation of telomere maintenance via telomerase; protein folding; regulation of mitotic cell cycle IPR007052; IPR008978; Protein wos2 (p21) wos2 SPAC9E9.13 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR35842_c0_g1_i1 Q9XF57 PEX7_ARATH 1.00E-42 GO:0080008; GO:0005778; GO:0006625 Cul4-RING ubiquitin ligase complex; peroxisomal membrane; protein targeting to peroxisome IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Peroxisome biogenesis protein 7 (Peroxin-7) (AtPEX7) (Peroxisomal targeting signal type 2 receptor) (Pex7p) PEX7 At1g29260 F28N24.6 Arabidopsis thaliana (Mouse-ear cress) TR35842_c0_g1_i3 O00628 PEX7_HUMAN 6.00E-66 GO:0005829; GO:0001958; GO:0008611; GO:0006635; GO:0001764; GO:0005782; GO:0005053; GO:0042803; GO:0016558 cytosol; endochondral ossification; ether lipid biosynthetic process; fatty acid beta-oxidation; neuron migration; peroxisomal matrix; peroxisome matrix targeting signal-2 binding; protein homodimerization activity; protein import into peroxisome matrix IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7) PEX7 PTS2R Homo sapiens (Human) TR35842_c0_g2_i1 P39108 PEX7_YEAST 6.00E-28 GO:0005829; GO:0005777; GO:0005053; GO:0016560 P38855; P50091; P27796 "cytosol; peroxisome; peroxisome matrix targeting signal-2 binding; protein import into peroxisome matrix, docking" IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7) (Peroxisome import protein PAS7) PEX7 PAS7 PEB1 YDR142C YD2943.01C YD9302.18C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR35845_c1_g1_i2 Q008S8 ECT2L_HUMAN 5.00E-19 GO:0005089; GO:0035023 Rho guanyl-nucleotide exchange factor activity; regulation of Rho protein signal transduction IPR000219; IPR001810; IPR011993; Epithelial cell-transforming sequence 2 oncogene-like (Lung-specific F-box and DH domain-containing protein) (Putative guanine nucleotide exchange factor LFDH) ECT2L C6orf91 LFDH Homo sapiens (Human) TR35847_c5_g1_i1 Q80T91 MEG11_MOUSE 4.00E-06 GO:0016323; GO:0034109; GO:0016021; GO:0010842 basolateral plasma membrane; homotypic cell-cell adhesion; integral to membrane; retina layer formation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) TR35847_c5_g1_i4 Q8NCF0 CL18C_HUMAN 2.00E-06 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001283; IPR001304; IPR016186; IPR018378; IPR016187; IPR014044; IPR000742; IPR013032; C-type lectin domain family 18 member C (Mannose receptor-like protein 3) CLEC18C MRLP3 Homo sapiens (Human) TR35847_c5_g2_i1 Q8TE58 ATS15_HUMAN 2.00E-33 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR013277; IPR001590; IPR013273; IPR002870; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAM-TS 15) (ADAM-TS15) (ADAMTS-15) (EC 3.4.24.-) ADAMTS15 Homo sapiens (Human) TR35851_c4_g1_i1 Q00223 XP4_XENLA 1.00E-29 GO:0005576 extracellular region IPR000519; IPR017994; IPR017957; Putative gastrointestinal growth factor xP4 (TFF p4.1) p4 Xenopus laevis (African clawed frog) TR35851_c4_g2_i3 P10667 MUA1_XENLA 6.00E-17 GO:0005576 extracellular region IPR000519; IPR017994; IPR017957; Integumentary mucin A.1 (FIM-A.1) (Preprospasmolysin) Xenopus laevis (African clawed frog) TR35851_c4_g2_i4 P17437 XP2_XENLA 2.00E-18 GO:0005576 extracellular region IPR000519; IPR017994; IPR017957; Skin secretory protein xP2 (Protein APEG) p2 Xenopus laevis (African clawed frog) TR35851_c4_g2_i5 Q00223 XP4_XENLA 5.00E-32 GO:0005576 extracellular region IPR000519; IPR017994; IPR017957; Putative gastrointestinal growth factor xP4 (TFF p4.1) p4 Xenopus laevis (African clawed frog) TR35851_c5_g1_i1 P12890 AMDB_XENLA 6.00E-64 GO:0005507; GO:0016021; GO:0006518; GO:0004598; GO:0004504; GO:0030658 copper ion binding; integral to membrane; peptide metabolic process; peptidylamidoglycolate lyase activity; peptidylglycine monooxygenase activity; transport vesicle membrane IPR011042; IPR014784; IPR020611; IPR014783; IPR000323; IPR001258; IPR013017; IPR000720; IPR008977; Peptidyl-glycine alpha-amidating monooxygenase B (PAM-B) (Peptide C-terminal alpha-amidating enzyme II) (AE-II) (Peptidyl-glycine alpha-amidating monooxygenase II) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase B (PHM-B) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase B (EC 4.3.2.5) (Peptidylamidoglycolate lyase-B) (PAL-B)] pam-b Xenopus laevis (African clawed frog) TR35852_c1_g1_i1 Q92781 RDH1_HUMAN 6.00E-33 GO:0005788; GO:0005789; GO:0007603; GO:0001523; GO:0004745; GO:0042572; GO:0007601 "endoplasmic reticulum lumen; endoplasmic reticulum membrane; phototransduction, visible light; retinoid metabolic process; retinol dehydrogenase activity; retinol metabolic process; visual perception" IPR002198; IPR002347; IPR016040; Cofactor metabolism; retinol metabolism. 11-cis retinol dehydrogenase (11-cis RDH) (11-cis RoDH) (EC 1.1.1.315) (9-cis retinol dehydrogenase) (9cRDH) RDH5 RDH1 Homo sapiens (Human) TR35852_c1_g1_i2 P37059 DHB2_HUMAN 3.00E-58 GO:0047006; GO:0005789; GO:0004303; GO:0001701; GO:0016021; GO:0001890; GO:0032526; GO:0006694; GO:0047035 "17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity; endoplasmic reticulum membrane; estradiol 17-beta-dehydrogenase activity; in utero embryonic development; integral to membrane; placenta development; response to retinoic acid; steroid biosynthetic process; testosterone dehydrogenase (NAD+) activity" IPR002198; IPR002347; IPR016040; IPR020904; Estradiol 17-beta-dehydrogenase 2 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 2) (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) HSD17B2 EDH17B2 Homo sapiens (Human) TR35852_c1_g1_i3 O54753 H17B6_RAT 3.00E-37 GO:0008209; GO:0005789; GO:0004303; GO:0004745; GO:0047035 androgen metabolic process; endoplasmic reticulum membrane; estradiol 17-beta-dehydrogenase activity; retinol dehydrogenase activity; testosterone dehydrogenase (NAD+) activity IPR002198; IPR002347; IPR016040; IPR020904; 17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.239) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) Hsd17b6 Hsd17b9 Rattus norvegicus (Rat) TR35852_c1_g1_i4 P37059 DHB2_HUMAN 4.00E-59 GO:0047006; GO:0005789; GO:0004303; GO:0001701; GO:0016021; GO:0001890; GO:0032526; GO:0006694; GO:0047035 "17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity; endoplasmic reticulum membrane; estradiol 17-beta-dehydrogenase activity; in utero embryonic development; integral to membrane; placenta development; response to retinoic acid; steroid biosynthetic process; testosterone dehydrogenase (NAD+) activity" IPR002198; IPR002347; IPR016040; IPR020904; Estradiol 17-beta-dehydrogenase 2 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 2) (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) HSD17B2 EDH17B2 Homo sapiens (Human) TR35852_c1_g1_i5 Q02337 BDH_BOVIN 2.00E-52 GO:0003858; GO:0005743; GO:0005759 3-hydroxybutyrate dehydrogenase activity; mitochondrial inner membrane; mitochondrial matrix IPR002198; IPR002347; IPR016040; IPR020904; "D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase)" BDH1 BDH Bos taurus (Bovine) TR35852_c1_g1_i6 P86198 BDH_MESAU 1.00E-14 GO:0003858; GO:0005759 3-hydroxybutyrate dehydrogenase activity; mitochondrial matrix IPR016040; "D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (Fragments)" BDH1 BDH Mesocricetus auratus (Golden hamster) TR35855_c0_g1_i1 Q09575 YRD6_CAEEL 3.00E-38 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR35857_c2_g3_i3 Q5XHG1 NSMA3_XENLA 5.00E-63 GO:0000139; GO:0005789; GO:0016021; GO:0046872; GO:0050290; GO:0004767 Golgi membrane; endoplasmic reticulum membrane; integral to membrane; metal ion binding; sphingomyelin phosphodiesterase D activity; sphingomyelin phosphodiesterase activity IPR024129; Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III) smpd4 Xenopus laevis (African clawed frog) TR35859_c1_g2_i1 B3A0Q8 PLSP2_LOTGI 1.00E-23 GO:0005576; GO:0020037; GO:0004601; GO:0006979 extracellular region; heme binding; peroxidase activity; response to oxidative stress IPR010255; IPR002007; IPR019791; Peroxidase-like protein 3 (Fragment) Lottia gigantea (Giant owl limpet) TR35859_c1_g3_i1 Q7QH73 PERC_ANOGA 1.00E-55 GO:0005576; GO:0020037; GO:0042744; GO:0046872; GO:0004601 extracellular region; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity IPR010255; IPR002007; IPR019791; Chorion peroxidase (EC 1.11.1.7) pxt AGAP004038 Anopheles gambiae (African malaria mosquito) TR35859_c1_g3_i3 P70682 PGH2_CAVPO 7.00E-11 GO:0019371; GO:0005737; GO:0051213; GO:0005789; GO:0020037; GO:0046872; GO:0005634; GO:0004601; GO:0004666; GO:0008217; GO:0006979 cyclooxygenase pathway; cytoplasm; dioxygenase activity; endoplasmic reticulum membrane; heme binding; metal ion binding; nucleus; peroxidase activity; prostaglandin-endoperoxide synthase activity; regulation of blood pressure; response to oxidative stress IPR000742; IPR010255; IPR002007; IPR019791; Lipid metabolism; prostaglandin biosynthesis. Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) PTGS2 COX2 Cavia porcellus (Guinea pig) TR35861_c1_g1_i1 O42130 TOP2A_CHICK 0 GO:0005524; GO:0008301; GO:0006266; GO:0009330; GO:0003918; GO:0006265; GO:0006261; GO:0030263; GO:0008144; GO:0000287; GO:0006312; GO:0005654; GO:0043065; GO:0000712; GO:0006974; GO:0000819; GO:0000795 "ATP binding; DNA binding, bending; DNA ligation; DNA topoisomerase complex (ATP-hydrolyzing); DNA topoisomerase type II (ATP-hydrolyzing) activity; DNA topological change; DNA-dependent DNA replication; apoptotic chromosome condensation; drug binding; magnesium ion binding; mitotic recombination; nucleoplasm; positive regulation of apoptotic process; resolution of meiotic recombination intermediates; response to DNA damage stimulus; sister chromatid segregation; synaptonemal complex" IPR024946; IPR012542; IPR003594; IPR020568; IPR014721; IPR001241; IPR002205; IPR013758; IPR013757; IPR013506; IPR013759; IPR013760; IPR018522; IPR006171; "DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme)" TOP2A Gallus gallus (Chicken) TR35861_c1_g1_i3 O42131 TOP2B_CHICK 0 GO:0005524; GO:0003677; GO:0003918; GO:0006265; GO:0006261; GO:0071778; GO:0003682; GO:0042826; GO:0046872; GO:0006312; GO:0005654; GO:0005080; GO:0000712; GO:0000819; GO:0000795 ATP binding; DNA binding; DNA topoisomerase type II (ATP-hydrolyzing) activity; DNA topological change; DNA-dependent DNA replication; WINAC complex; chromatin binding; histone deacetylase binding; metal ion binding; mitotic recombination; nucleoplasm; protein kinase C binding; resolution of meiotic recombination intermediates; sister chromatid segregation; synaptonemal complex IPR024946; IPR012542; IPR003594; IPR020568; IPR014721; IPR001241; IPR002205; IPR013758; IPR013757; IPR013506; IPR013759; IPR013760; IPR018522; IPR006171; "DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme)" TOP2B Gallus gallus (Chicken) TR35863_c0_g1_i1 Q9SA23 SYP51_ARATH 6.00E-15 GO:0005794; GO:0005484; GO:0010008; GO:0016021; GO:0006886; GO:0031902; GO:0005773; GO:0016192 Q946Y7 Golgi apparatus; SNAP receptor activity; endosome membrane; integral to membrane; intracellular protein transport; late endosome membrane; vacuole; vesicle-mediated transport IPR006012; IPR000727; Syntaxin-51 (AtSYP51) SYP51 At1g16240 F3O9.4 Arabidopsis thaliana (Mouse-ear cress) TR35863_c0_g1_i2 Q3T075 STX8_BOVIN 6.00E-42 GO:0005484; GO:0031201; GO:0016021; GO:0006886; GO:0006906 SNAP receptor activity; SNARE complex; integral to membrane; intracellular protein transport; vesicle fusion IPR015640; IPR000727; Syntaxin-8 STX8 Bos taurus (Bovine) TR35864_c0_g1_i1 B4QUC0 MOC2B_DROSI 4.00E-19 GO:0030366; GO:0005829; GO:0016740 Mo-molybdopterin synthase activity; cytosol; transferase activity IPR003448; Cofactor biosynthesis; molybdopterin biosynthesis. Molybdopterin synthase catalytic subunit (EC 2.8.1.12) (Molybdenum cofactor synthesis protein 2 large subunit) (Molybdenum cofactor synthesis protein 2B) (MOCS2B) Mocs2 GD18232 Drosophila simulans (Fruit fly) TR35864_c0_g1_i2 Q9NS73 MBIP1_HUMAN 4.00E-41 GO:0005671; GO:0005737; GO:0043966; GO:0000173; GO:0005730; GO:0004860 Itself; Q9H8E8; Q96HL7; P51116; Q9H8W4; Q13136 Ada2/Gcn5/Ada3 transcription activator complex; cytoplasm; histone H3 acetylation; inactivation of MAPK activity involved in osmosensory signaling pathway; nucleolus; protein kinase inhibitor activity IPR026062; MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein) MBIP BM-015 Homo sapiens (Human) TR35868_c0_g1_i1 P40757 ALN_LITCT 8.00E-137 GO:0000256; GO:0004038; GO:0050897; GO:0005739; GO:0008270 allantoin catabolic process; allantoinase activity; cobalt ion binding; mitochondrion; zinc ion binding IPR017593; IPR002195; IPR011059; Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1. "Allantoinase, mitochondrial (EC 3.5.2.5)" ALN Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) TR35868_c0_g1_i2 P40757 ALN_LITCT 3.00E-132 GO:0000256; GO:0004038; GO:0050897; GO:0005739; GO:0008270 allantoin catabolic process; allantoinase activity; cobalt ion binding; mitochondrion; zinc ion binding IPR017593; IPR002195; IPR011059; Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1. "Allantoinase, mitochondrial (EC 3.5.2.5)" ALN Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) TR35869_c0_g1_i2 Q969V4 TEKT1_HUMAN 9.00E-142 GO:0035085; GO:0005737; GO:0005874; GO:0000226 cilium axoneme; cytoplasm; microtubule; microtubule cytoskeleton organization IPR000435; Tektin-1 TEKT1 Homo sapiens (Human) TR35870_c2_g1_i1 Q8C9B9 DIDO1_MOUSE 3.00E-16 GO:0097190; GO:0005737; GO:0005654; GO:0006351; GO:0008270 "apoptotic signaling pathway; cytoplasm; nucleoplasm; transcription, DNA-dependent; zinc ion binding" IPR012921; IPR003618; IPR017890; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) Dido1 Datf1 Dio1 Mus musculus (Mouse) TR35871_c1_g1_i1 O75093 SLIT1_HUMAN 9.00E-30 GO:0048846; GO:0005509; GO:0005737; GO:0033563; GO:0040023; GO:0005615; GO:0048853; GO:0008045; GO:0050919; GO:0048843; GO:0051964; GO:0031290; GO:0021510; GO:0022028 axon extension involved in axon guidance; calcium ion binding; cytoplasm; dorsal/ventral axon guidance; establishment of nucleus localization; extracellular space; forebrain morphogenesis; motor neuron axon guidance; negative chemotaxis; negative regulation of axon extension involved in axon guidance; negative regulation of synapse assembly; retinal ganglion cell axon guidance; spinal cord development; tangential migration from the subventricular zone to the olfactory bulb IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR009030; IPR001791; IPR001611; IPR025875; IPR003591; IPR000372; Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4) SLIT1 KIAA0813 MEGF4 SLIL1 Homo sapiens (Human) TR35872_c1_g1_i2 Q3MHJ0 K1143_BOVIN 2.00E-13 IPR027911; Uncharacterized protein KIAA1143 homolog Bos taurus (Bovine) TR35874_c3_g1_i3 P25107 PTH1R_DIDVI 7.00E-78 GO:0007188; GO:0005887; GO:0004991; GO:0017046; GO:0043621 adenylate cyclase-modulating G-protein coupled receptor signaling pathway; integral to plasma membrane; parathyroid hormone receptor activity; peptide hormone binding; protein self-association IPR017981; IPR001879; IPR002170; IPR000832; IPR017983; Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) PTH1R PTHR PTHR1 Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) TR35875_c0_g3_i1 Q8CFG9 C1RB_MOUSE 3.00E-06 GO:0005509; GO:0006958; GO:0005576; GO:0045087; GO:0006508; GO:0004252 "calcium ion binding; complement activation, classical pathway; extracellular region; innate immune response; proteolysis; serine-type endopeptidase activity" IPR000859; IPR001881; IPR013032; IPR000152; IPR018097; IPR024175; IPR001254; IPR018114; IPR001314; IPR000436; IPR009003; Complement C1r-B subcomponent (EC 3.4.21.41) (Complement component 1 subcomponent r-B) [Cleaved into: Complement C1r-B subcomponent heavy chain; Complement C1r-B subcomponent light chain] C1rb C1r Mus musculus (Mouse) TR35875_c1_g1_i1 B4F785 EGFLA_RAT 1.00E-133 GO:0030054; GO:0005578; GO:0045202 cell junction; proteinaceous extracellular matrix; synapse IPR008985; IPR013320; IPR000742; IPR013032; IPR003961; IPR013783; IPR001791; "Pikachurin (EGF-like, fibronectin type-III and laminin G-like domain-containing protein)" Egflam Rattus norvegicus (Rat) TR35879_c0_g1_i1 Q9JJ66 CDC20_MOUSE 0 GO:0051488; GO:0005680; GO:0031145; GO:0030154; GO:0051301; GO:0005737; GO:0005815; GO:0007067; GO:0007399; GO:0090129; GO:0031915; GO:0016567; GO:0040020; GO:0000922 Q8CDI2; Q8VDQ8 activation of anaphase-promoting complex activity; anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell differentiation; cell division; cytoplasm; microtubule organizing center; mitosis; nervous system development; positive regulation of synapse maturation; positive regulation of synaptic plasticity; protein ubiquitination; regulation of meiosis; spindle pole IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. Cell division cycle protein 20 homolog (mmCdc20) (p55CDC) Cdc20 Mus musculus (Mouse) TR35881_c0_g1_i1 Q9P000 COMD9_HUMAN 3.00E-57 IPR017920; IPR009886; COMM domain-containing protein 9 COMMD9 HSPC166 Homo sapiens (Human) TR35882_c0_g1_i1 Q9RA05 LIMC_RHOER 5.00E-18 GO:0046251; GO:0016616 "limonene catabolic process; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" IPR023985; IPR002198; IPR002347; IPR016040; IPR020904; Terpene metabolism; limonene degradation. "(-)-trans-carveol dehydrogenase (EC 1.1.1.n4) ((4R,6S)-carveol dehydrogenase) (CDH) (Carveol dehydrogenase)" limC Rhodococcus erythropolis (Arthrobacter picolinophilus) TR35882_c0_g1_i2 Q5RBV3 DECR2_PONAB 1.00E-110 GO:0008670; GO:0006631; GO:0005777 "2,4-dienoyl-CoA reductase (NADPH) activity; fatty acid metabolic process; peroxisome" IPR002198; IPR002347; IPR016040; "Peroxisomal 2,4-dienoyl-CoA reductase (EC 1.3.1.34) (2,4-dienoyl-CoA reductase 2)" DECR2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35882_c0_g1_i3 Q6NV34 DECR2_DANRE 9.00E-112 GO:0008670; GO:0006631; GO:0005777 "2,4-dienoyl-CoA reductase (NADPH) activity; fatty acid metabolic process; peroxisome" IPR002198; IPR002347; IPR016040; "Peroxisomal 2,4-dienoyl-CoA reductase (EC 1.3.1.34) (2,4-dienoyl-CoA reductase 2)" decr2 si:ch211-153c20.5 zgc:85626 Danio rerio (Zebrafish) (Brachydanio rerio) TR35883_c0_g1_i1 Q641F0 F213A_XENLA 5.00E-52 GO:0016209; GO:0005737 antioxidant activity; cytoplasm Redox-regulatory protein FAM213A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) (Protein PAMM) fam213a pamm Xenopus laevis (African clawed frog) TR35883_c0_g1_i5 Q641F0 F213A_XENLA 2.00E-53 GO:0016209; GO:0005737 antioxidant activity; cytoplasm Redox-regulatory protein FAM213A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) (Protein PAMM) fam213a pamm Xenopus laevis (African clawed frog) TR35883_c0_g1_i6 Q5ZI34 F213A_CHICK 4.00E-52 GO:0016209; GO:0005737; GO:0055114; GO:0045670 antioxidant activity; cytoplasm; oxidation-reduction process; regulation of osteoclast differentiation IPR012336; Redox-regulatory protein FAM213A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) (Protein PAMM) FAM213A PAMM RCJMB04_30m16 Gallus gallus (Chicken) TR35886_c2_g1_i3 Q4FZY0 EFHD2_RAT 2.00E-56 GO:0005509; GO:0045121 calcium ion binding; membrane raft IPR011992; IPR002048; EF-hand domain-containing protein D2 (Swiprosin-1) Efhd2 Sws1 Rattus norvegicus (Rat) TR35886_c2_g1_i9 Q4FZY0 EFHD2_RAT 2.00E-56 GO:0005509; GO:0045121 calcium ion binding; membrane raft IPR011992; IPR002048; EF-hand domain-containing protein D2 (Swiprosin-1) Efhd2 Sws1 Rattus norvegicus (Rat) TR35888_c0_g1_i1 Q9NZR2 LRP1B_HUMAN 2.00E-12 GO:0005509; GO:0016021; GO:0005041; GO:0015031; GO:0006898 calcium ion binding; integral to membrane; low-density lipoprotein receptor activity; protein transport; receptor-mediated endocytosis IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) LRP1B LRPDIT Homo sapiens (Human) TR35888_c0_g1_i2 P01130 LDLR_HUMAN 7.00E-07 GO:0005794; GO:0005509; GO:0042632; GO:0070508; GO:0008203; GO:0030669; GO:0005905; GO:0005769; GO:0010008; GO:0009897; GO:0005887; GO:0030299; GO:0005770; GO:0042159; GO:0042157; GO:0034362; GO:0030169; GO:0034383; GO:0005041; GO:0005764; GO:0019048; GO:0015914; GO:0007603; GO:0010867; GO:0010899; GO:0001523; GO:0044281; GO:0030229 Q8NBP7 "Golgi apparatus; calcium ion binding; cholesterol homeostasis; cholesterol import; cholesterol metabolic process; clathrin-coated endocytic vesicle membrane; coated pit; early endosome; endosome membrane; external side of plasma membrane; integral to plasma membrane; intestinal cholesterol absorption; late endosome; lipoprotein catabolic process; lipoprotein metabolic process; low-density lipoprotein particle; low-density lipoprotein particle binding; low-density lipoprotein particle clearance; low-density lipoprotein receptor activity; lysosome; modulation by virus of host morphology or physiology; phospholipid transport; phototransduction, visible light; positive regulation of triglyceride biosynthetic process; regulation of phosphatidylcholine catabolic process; retinoid metabolic process; small molecule metabolic process; very-low-density lipoprotein particle receptor activity" IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor (LDL receptor) LDLR Homo sapiens (Human) TR35889_c0_g2_i1 Q76KJ5 RPA34_MOUSE 1.00E-06 GO:0005736; GO:0005739; GO:0009303 DNA-directed RNA polymerase I complex; mitochondrion; rRNA transcription IPR013240; DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Anti-sense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (RNA polymerase I-associated factor PAF49) Cd3eap Ase1 Paf49 Mus musculus (Mouse) TR35891_c1_g1_i2 Q7Z4L5 TT21B_HUMAN 0 GO:0035085; GO:0060271; GO:0005856; GO:0042073; GO:0030991; GO:0007224 cilium axoneme; cilium morphogenesis; cytoskeleton; intraflagellar transport; intraflagellar transport particle A; smoothened signaling pathway IPR013026; IPR011990; IPR001440; IPR013105; IPR019734; Tetratricopeptide repeat protein 21B (TPR repeat protein 21B) TTC21B KIAA1992 Nbla10696 Homo sapiens (Human) TR35893_c0_g2_i2 Q96MM6 HS12B_HUMAN 5.00E-76 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR35893_c0_g2_i3 Q96MM6 HS12B_HUMAN 7.00E-105 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR35894_c0_g1_i4 Q3ZBG9 PLS2_BOVIN 5.00E-48 GO:0016021; GO:0046872 integral to membrane; metal ion binding IPR005552; Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) TR35897_c0_g1_i2 Q8IY37 DHX37_HUMAN 0 GO:0005524; GO:0008026; GO:0003676 ATP binding; ATP-dependent helicase activity; nucleic acid binding IPR011545; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Probable ATP-dependent RNA helicase DHX37 (EC 3.6.4.13) (DEAH box protein 37) DHX37 DDX37 KIAA1517 Homo sapiens (Human) TR35897_c0_g1_i3 Q9HDY4 YK16_SCHPO 3.00E-95 GO:0005524; GO:0004004; GO:0003723; GO:0030490; GO:0005730; GO:0032040 ATP binding; ATP-dependent RNA helicase activity; RNA binding; maturation of SSU-rRNA; nucleolus; small-subunit processome IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Putative ATP-dependent RNA helicase PB1A10.06c (EC 3.6.4.13) SPAPB1A10.06c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR35897_c0_g1_i4 Q96662 POLG_BVDVC 7.00E-06 GO:0005524; GO:0008026; GO:0003723; GO:0003968; GO:0075512; GO:0004197; GO:0039654; GO:0033644; GO:0044228; GO:0039520; GO:0016021; GO:0006811; GO:0006508; GO:0033897; GO:0004252; GO:0070008; GO:0039548; GO:0039501; GO:0006351; GO:0019062; GO:0019079; GO:0019082 "ATP binding; ATP-dependent helicase activity; RNA binding; RNA-directed RNA polymerase activity; clathrin-mediated endocytosis of virus by host cell; cysteine-type endopeptidase activity; fusion of virus membrane with host endosome membrane; host cell membrane; host cell surface; induction by virus of host autophagy; integral to membrane; ion transport; proteolysis; ribonuclease T2 activity; serine-type endopeptidase activity; serine-type exopeptidase activity; suppression by virus of host IRF3 activity; suppression by virus of host type I interferon production; transcription, DNA-dependent; viral attachment to host cell; viral genome replication; viral protein processing" IPR021824; IPR011492; IPR014001; IPR001650; IPR027417; IPR022120; IPR008751; IPR000280; IPR007094; IPR002166; IPR001568; IPR018188; Genome polyprotein [Cleaved into: N-terminal protease (N-pro) (EC 3.4.22.-) (Autoprotease p20); Capsid protein C; E(rns) glycoprotein (gp44/48); Envelope glycoprotein E1 (gp33); Envelope glycoprotein E2 (gp55); p7; Non-structural protein 2-3; Cysteine protease NS2 (EC 3.4.22.-) (Non-structural protein 2); Serine protease NS3 (EC 3.4.21.113) (EC 3.6.1.15) (EC 3.6.4.13) (Non-structural protein 3); Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); Non-structural protein 5A (NS5A); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B)] Bovine viral diarrhea virus (strain CP7) (BVDV) (Mucosal disease virus) TR35897_c0_g1_i5 O46072 KZ_DROME 2.00E-180 GO:0005524; GO:0008026; GO:0003723; GO:0004386; GO:0022008 ATP binding; ATP-dependent helicase activity; RNA binding; helicase activity; neurogenesis IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Probable ATP-dependent RNA helicase kurz (EC 3.6.4.13) kz CG3228 Drosophila melanogaster (Fruit fly) TR35897_c0_g1_i6 B4LX81 SPNE_DROVI 2.00E-29 GO:0005524; GO:0008026; GO:0030154; GO:0005737; GO:0031047; GO:0007126; GO:0046872; GO:0007275; GO:0003676; GO:0048477; GO:0007283 ATP binding; ATP-dependent helicase activity; cell differentiation; cytoplasm; gene silencing by RNA; meiosis; metal ion binding; multicellular organismal development; nucleic acid binding; oogenesis; spermatogenesis IPR011545; IPR007502; IPR014001; IPR001650; IPR027417; IPR002999; IPR007087; IPR015880; Probable ATP-dependent RNA helicase spindle-E (EC 3.6.4.13) (Homeless) spn-E hls GJ23765 Drosophila virilis (Fruit fly) TR35897_c0_g1_i7 Q8IY37 DHX37_HUMAN 0 GO:0005524; GO:0008026; GO:0003676 ATP binding; ATP-dependent helicase activity; nucleic acid binding IPR011545; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Probable ATP-dependent RNA helicase DHX37 (EC 3.6.4.13) (DEAH box protein 37) DHX37 DDX37 KIAA1517 Homo sapiens (Human) TR35898_c2_g1_i1 Q9LDH0 XYLT_ARATH 2.00E-22 GO:0032580; GO:0005797; GO:0000139; GO:0050513; GO:0016021; GO:0031204; GO:0006487 "Golgi cisterna membrane; Golgi medial cisterna; Golgi membrane; glycoprotein 2-beta-D-xylosyltransferase activity; integral to membrane; posttranslational protein targeting to membrane, translocation; protein N-linked glycosylation" IPR007657; Protein modification; protein glycosylation. "Beta-(1,2)-xylosyltransferase (EC 2.4.2.38)" XYLT At5g55500 MTE17.21 Arabidopsis thaliana (Mouse-ear cress) TR35899_c1_g1_i2 Q6AZB8 HARB1_DANRE 6.00E-54 GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) TR35901_c0_g3_i1 Q20758 ARL1_CAEEL 3.00E-94 GO:0005525; GO:0005794; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 1 arl-1 F54C9.10 Caenorhabditis elegans TR35901_c0_g3_i3 Q20758 ARL1_CAEEL 3.00E-94 GO:0005525; GO:0005794; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 1 arl-1 F54C9.10 Caenorhabditis elegans TR35903_c0_g1_i1 Q54C11 Y3202_DICDI 3.00E-09 GO:0005737; GO:0004842; GO:0008270 cytoplasm; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR013323; IPR008974; IPR001293; TNF receptor-associated factor family protein DDB_G0293202 DDB_G0293202 Dictyostelium discoideum (Slime mold) TR35903_c0_g1_i3 Q54C11 Y3202_DICDI 3.00E-09 GO:0005737; GO:0004842; GO:0008270 cytoplasm; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR013323; IPR008974; IPR001293; TNF receptor-associated factor family protein DDB_G0293202 DDB_G0293202 Dictyostelium discoideum (Slime mold) TR35903_c0_g1_i4 Q6IWL4 TRAF6_DANRE 4.00E-10 GO:0050852; GO:0007250; GO:0046849; GO:0048468; GO:0005737; GO:0045087; GO:0070498; GO:0009887; GO:0001503; GO:0043123; GO:0043507; GO:0031666; GO:0045672; GO:0045893; GO:0070534; GO:0051865; GO:0042981; GO:0009617; GO:0009615; GO:0004871; GO:0004842; GO:0008270 "T cell receptor signaling pathway; activation of NF-kappaB-inducing kinase activity; bone remodeling; cell development; cytoplasm; innate immune response; interleukin-1-mediated signaling pathway; organ morphogenesis; ossification; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JUN kinase activity; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of osteoclast differentiation; positive regulation of transcription, DNA-dependent; protein K63-linked ubiquitination; protein autoubiquitination; regulation of apoptotic process; response to bacterium; response to virus; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding" IPR002083; IPR013323; IPR012227; IPR008974; IPR027139; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. TNF receptor-associated factor 6 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF6) traf6 si:dkey-56p7.3 zgc:63704 Danio rerio (Zebrafish) (Brachydanio rerio) TR35905_c0_g2_i1 Q93LL2 ACSA_NOSLI 5.00E-63 GO:0005524; GO:0003987; GO:0046872 ATP binding; acetate-CoA ligase activity; metal ion binding IPR020459; IPR020845; IPR000873; Acetyl-coenzyme A synthetase (AcCoA synthetase) (Acs) (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme) (Fragment) acsA Nostoc linckia TR35905_c1_g1_i1 A7MB45 ACSS3_BOVIN 7.00E-40 GO:0005524; GO:0003987; GO:0005739 ATP binding; acetate-CoA ligase activity; mitochondrion IPR025110; IPR020845; IPR000873; "Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC 6.2.1.1)" ACSS3 Bos taurus (Bovine) TR35905_c3_g1_i1 Q9VP61 ACSA_DROME 3.00E-122 GO:0016208; GO:0005524; GO:0003987; GO:0019427; GO:0048149; GO:0005737 AMP binding; ATP binding; acetate-CoA ligase activity; acetyl-CoA biosynthetic process from acetate; behavioral response to ethanol; cytoplasm IPR011904; IPR025110; IPR020845; IPR000873; Acetyl-coenzyme A synthetase (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acyl-activating enzyme) AcCoAS CG9390 Drosophila melanogaster (Fruit fly) TR35906_c1_g1_i1 P00522 ABL_DROME 8.00E-179 GO:0005524; GO:0045179; GO:0030424; GO:0016199; GO:0005911; GO:0007417; GO:0007303; GO:0005829; GO:0007391; GO:0003382; GO:0019897; GO:0008045; GO:0005927; GO:0045886; GO:0001764; GO:0004715; GO:0003402; GO:0008064; GO:0008360; GO:0032880; GO:0031647; GO:0007370 Q8T4F7; P16621 "ATP binding; apical cortex; axon; axon midline choice point recognition; cell-cell junction; central nervous system development; cytoplasmic transport, nurse cell to oocyte; cytosol; dorsal closure; epithelial cell morphogenesis; extrinsic to plasma membrane; motor neuron axon guidance; muscle tendon junction; negative regulation of synaptic growth at neuromuscular junction; neuron migration; non-membrane spanning protein tyrosine kinase activity; planar cell polarity pathway involved in axis elongation; regulation of actin polymerization or depolymerization; regulation of cell shape; regulation of protein localization; regulation of protein stability; ventral furrow formation" IPR015015; IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase Abl (EC 2.7.10.2) (D-ash) (Protein abelson) Abl ABL-1 Dash CG4032 Drosophila melanogaster (Fruit fly) TR35906_c1_g1_i2 A6QLK6 GRAP_BOVIN 2.00E-20 IPR000108; IPR000980; IPR011511; IPR001452; GRB2-related adapter protein GRAP Bos taurus (Bovine) TR35906_c3_g1_i1 Q86PM4 FGFR_HYDVU 6.00E-22 GO:0005524; GO:0005007; GO:0016021; GO:0018108; GO:0008284 ATP binding; fibroblast growth factor-activated receptor activity; integral to membrane; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor (EC 2.7.10.1) (Protein kringelchen) FGFR Hydra vulgaris (Hydra) (Hydra attenuata) TR35906_c3_g1_i6 P00522 ABL_DROME 4.00E-40 GO:0005524; GO:0045179; GO:0030424; GO:0016199; GO:0005911; GO:0007417; GO:0007303; GO:0005829; GO:0007391; GO:0003382; GO:0019897; GO:0008045; GO:0005927; GO:0045886; GO:0001764; GO:0004715; GO:0003402; GO:0008064; GO:0008360; GO:0032880; GO:0031647; GO:0007370 Q8T4F7; P16621 "ATP binding; apical cortex; axon; axon midline choice point recognition; cell-cell junction; central nervous system development; cytoplasmic transport, nurse cell to oocyte; cytosol; dorsal closure; epithelial cell morphogenesis; extrinsic to plasma membrane; motor neuron axon guidance; muscle tendon junction; negative regulation of synaptic growth at neuromuscular junction; neuron migration; non-membrane spanning protein tyrosine kinase activity; planar cell polarity pathway involved in axis elongation; regulation of actin polymerization or depolymerization; regulation of cell shape; regulation of protein localization; regulation of protein stability; ventral furrow formation" IPR015015; IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase Abl (EC 2.7.10.2) (D-ash) (Protein abelson) Abl ABL-1 Dash CG4032 Drosophila melanogaster (Fruit fly) TR35907_c0_g1_i1 Q8TDY8 IGDC4_HUMAN 3.00E-08 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; Immunoglobulin superfamily DCC subclass member 4 (Neighbor of punc e11) (Protein DDM36) (hDDM36) IGDCC4 DDM36 KIAA1628 NOPE Homo sapiens (Human) TR35909_c6_g1_i1 Q91YJ2 SNX4_MOUSE 4.00E-121 GO:0007154; GO:0005868; GO:0031901; GO:0032456; GO:0035091; GO:0015031 cell communication; cytoplasmic dynein complex; early endosome membrane; endocytic recycling; phosphatidylinositol binding; protein transport IPR001683; Sorting nexin-4 Snx4 Mus musculus (Mouse) TR35911_c0_g1_i1 Q54IC9 DERL1_DICDI 5.00E-32 GO:0030433; GO:0030176; GO:0006986 ER-associated protein catabolic process; integral to endoplasmic reticulum membrane; response to unfolded protein IPR007599; Probable derlin-1 homolog derl1 DDB_G0288833 Dictyostelium discoideum (Slime mold) TR35911_c0_g1_i2 Q5RC74 DERL2_PONAB 3.00E-128 GO:0030433; GO:0030968; GO:0030176; GO:0030307; GO:0008284; GO:0030970 "ER-associated protein catabolic process; endoplasmic reticulum unfolded protein response; integral to endoplasmic reticulum membrane; positive regulation of cell growth; positive regulation of cell proliferation; retrograde protein transport, ER to cytosol" IPR007599; Derlin-2 (Degradation in endoplasmic reticulum protein 2) (Der1-like protein 2) DERL2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR35912_c5_g1_i3 Q28DS3 RN170_XENTR 3.00E-66 GO:0005789; GO:0016021; GO:0016874; GO:0016567; GO:0008270 endoplasmic reticulum membrane; integral to membrane; ligase activity; protein ubiquitination; zinc ion binding IPR010652; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF170 (EC 6.3.2.-) (RING finger protein 170) rnf170 TGas116k14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35913_c0_g1_i1 O35598 ADA10_MOUSE 8.00E-112 GO:0005798; GO:0007220; GO:0007219; GO:0051088; GO:0042169; GO:0009986; GO:0051089; GO:0001701; GO:0016021; GO:0006509; GO:0004222; GO:0042117; GO:0007162; GO:0006913; GO:0005634; GO:0005886; GO:0010820; GO:0030307; GO:0008284; GO:0014069; GO:0019901; GO:0006468; GO:0034612; GO:0008270 Golgi-associated vesicle; Notch receptor processing; Notch signaling pathway; PMA-inducible membrane protein ectodomain proteolysis; SH2 domain binding; cell surface; constitutive protein ectodomain proteolysis; in utero embryonic development; integral to membrane; membrane protein ectodomain proteolysis; metalloendopeptidase activity; monocyte activation; negative regulation of cell adhesion; nucleocytoplasmic transport; nucleus; plasma membrane; positive regulation of T cell chemotaxis; positive regulation of cell growth; positive regulation of cell proliferation; postsynaptic density; protein kinase binding; protein phosphorylation; response to tumor necrosis factor; zinc ion binding IPR027053; IPR001762; IPR024079; IPR001590; IPR002870; Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c) Adam10 Kuz Madm Mus musculus (Mouse) TR35913_c0_g1_i3 O35598 ADA10_MOUSE 6.00E-122 GO:0005798; GO:0007220; GO:0007219; GO:0051088; GO:0042169; GO:0009986; GO:0051089; GO:0001701; GO:0016021; GO:0006509; GO:0004222; GO:0042117; GO:0007162; GO:0006913; GO:0005634; GO:0005886; GO:0010820; GO:0030307; GO:0008284; GO:0014069; GO:0019901; GO:0006468; GO:0034612; GO:0008270 Golgi-associated vesicle; Notch receptor processing; Notch signaling pathway; PMA-inducible membrane protein ectodomain proteolysis; SH2 domain binding; cell surface; constitutive protein ectodomain proteolysis; in utero embryonic development; integral to membrane; membrane protein ectodomain proteolysis; metalloendopeptidase activity; monocyte activation; negative regulation of cell adhesion; nucleocytoplasmic transport; nucleus; plasma membrane; positive regulation of T cell chemotaxis; positive regulation of cell growth; positive regulation of cell proliferation; postsynaptic density; protein kinase binding; protein phosphorylation; response to tumor necrosis factor; zinc ion binding IPR027053; IPR001762; IPR024079; IPR001590; IPR002870; Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c) Adam10 Kuz Madm Mus musculus (Mouse) TR35914_c2_g4_i1 Q8AV57 SDK2_CHICK 8.00E-45 GO:0007155; GO:0030054; GO:0016021; GO:0005886; GO:0045202 cell adhesion; cell junction; integral to membrane; plasma membrane; synapse IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013151; Protein sidekick-2 SDK2 Gallus gallus (Chicken) TR35914_c2_g4_i2 H2A0L7 FND1_PINMG 2.00E-32 GO:0005576 extracellular region IPR003961; IPR013783; Fibronectin type III domain-containing protein 1 Pinctada margaritifera (Black-lipped pearl oyster) TR35914_c2_g5_i1 Q64487 PTPRD_MOUSE 0 GO:0007157; GO:0016021; GO:0030182; GO:0035335; GO:0050775; GO:0097105; GO:0004725 P59823 heterophilic cell-cell adhesion; integral to membrane; neuron differentiation; peptidyl-tyrosine dephosphorylation; positive regulation of dendrite morphogenesis; presynaptic membrane assembly; protein tyrosine phosphatase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48) Ptprd Mus musculus (Mouse) TR35915_c0_g1_i1 Q9P218 COKA1_HUMAN 1.00E-16 GO:0005581; GO:0005788; GO:0030198; GO:0005576; GO:0005615 collagen; endoplasmic reticulum lumen; extracellular matrix organization; extracellular region; extracellular space IPR008160; IPR008985; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XX) chain COL20A1 KIAA1510 Homo sapiens (Human) TR35915_c0_g2_i1 A2AX52 CO6A4_MOUSE 5.00E-33 GO:0007155; GO:0005581; GO:0005576; GO:0043234; GO:0070208 cell adhesion; collagen; extracellular region; protein complex; protein heterotrimerization IPR008160; IPR002035; Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) TR35916_c8_g1_i1 P91620 SIF2_DROME 3.00E-165 GO:0030676; GO:0030054; GO:0035556; GO:0005543; GO:0051491; GO:0005057; GO:0032314; GO:0050770; GO:0050803; GO:0045202 Rac guanyl-nucleotide exchange factor activity; cell junction; intracellular signal transduction; phospholipid binding; positive regulation of filopodium assembly; receptor signaling protein activity; regulation of Rac GTPase activity; regulation of axonogenesis; regulation of synapse structure and activity; synapse IPR000219; IPR001331; IPR001478; IPR011993; IPR001849; IPR003116; "Protein still life, isoforms C/SIF type 2" sif CG34418 Drosophila melanogaster (Fruit fly) TR35916_c8_g1_i3 P91621 SIF1_DROME 4.00E-138 GO:0030676; GO:0030054; GO:0035556; GO:0005543; GO:0051491; GO:0005057; GO:0032314; GO:0050770; GO:0050803; GO:0045202 Rac guanyl-nucleotide exchange factor activity; cell junction; intracellular signal transduction; phospholipid binding; positive regulation of filopodium assembly; receptor signaling protein activity; regulation of Rac GTPase activity; regulation of axonogenesis; regulation of synapse structure and activity; synapse IPR000219; IPR001331; IPR001478; IPR011993; IPR001849; IPR003116; IPR000697; "Protein still life, isoform SIF type 1" sif CG34418 Drosophila melanogaster (Fruit fly) TR35916_c8_g1_i4 Q96DR7 ARHGQ_HUMAN 3.00E-10 GO:0005089; GO:0005543; GO:0035023; GO:0001726 Rho guanyl-nucleotide exchange factor activity; phospholipid binding; regulation of Rho protein signal transduction; ruffle IPR000219; IPR011993; IPR001849; IPR001452; Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) ARHGEF26 SGEF HMFN1864 Homo sapiens (Human) TR35916_c8_g1_i5 P91620 SIF2_DROME 3.00E-141 GO:0030676; GO:0030054; GO:0035556; GO:0005543; GO:0051491; GO:0005057; GO:0032314; GO:0050770; GO:0050803; GO:0045202 Rac guanyl-nucleotide exchange factor activity; cell junction; intracellular signal transduction; phospholipid binding; positive regulation of filopodium assembly; receptor signaling protein activity; regulation of Rac GTPase activity; regulation of axonogenesis; regulation of synapse structure and activity; synapse IPR000219; IPR001331; IPR001478; IPR011993; IPR001849; IPR003116; "Protein still life, isoforms C/SIF type 2" sif CG34418 Drosophila melanogaster (Fruit fly) TR35918_c5_g1_i1 O75031 HSF2B_HUMAN 5.00E-13 GO:0005829; GO:0007283; GO:0006366 cytosol; spermatogenesis; transcription from RNA polymerase II promoter IPR011989; IPR016024; Heat shock factor 2-binding protein HSF2BP Homo sapiens (Human) TR35918_c9_g4_i1 O75031 HSF2B_HUMAN 2.00E-24 GO:0005829; GO:0007283; GO:0006366 cytosol; spermatogenesis; transcription from RNA polymerase II promoter IPR011989; IPR016024; Heat shock factor 2-binding protein HSF2BP Homo sapiens (Human) TR35919_c0_g3_i1 Q5SY16 NOL9_HUMAN 4.00E-49 GO:0005524; GO:0003723; GO:0000460; GO:0005730; GO:0051731 ATP binding; RNA binding; maturation of 5.8S rRNA; nucleolus; polynucleotide 5'-hydroxyl-kinase activity IPR010655; Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.-) (Nucleolar protein 9) NOL9 Homo sapiens (Human) TR35921_c0_g2_i1 P44121 DNLI_HAEIN 2.00E-50 GO:0005524; GO:0003910; GO:0051103; GO:0006310; GO:0006260; GO:0046872 ATP binding; DNA ligase (ATP) activity; DNA ligation involved in DNA repair; DNA recombination; DNA replication; metal ion binding IPR012310; IPR016059; IPR012340; DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP]) ligA HI_1182/HI_1183 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) TR35923_c1_g1_i2 P21605 E3_VACCW 5.00E-10 GO:0003723; GO:0003726; GO:0039548; GO:0039557; GO:0039579; GO:0039580; GO:0039501; GO:0039502 RNA binding; double-stranded RNA adenosine deaminase activity; suppression by virus of host IRF3 activity; suppression by virus of host IRF7 activity; suppression by virus of host ISG15 activity; suppression by virus of host PKR activity; suppression by virus of host type I interferon production; suppression by virus of host type I interferon-mediated signaling pathway IPR014720; IPR000607; IPR009179; IPR011991; Protein E3 (p25) VACWR059 E3L Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) TR35923_c1_g1_i3 P55266 DSRAD_RAT 4.00E-53 GO:0003677; GO:0006382; GO:0005737; GO:0051607; GO:0003726; GO:0003725; GO:0031047; GO:0045087; GO:0006397; GO:0046872; GO:0044387; GO:0005730; GO:0045070; GO:0006355; GO:0035455; GO:0009615; GO:0044530; GO:0006351 "DNA binding; adenosine to inosine editing; cytoplasm; defense response to virus; double-stranded RNA adenosine deaminase activity; double-stranded RNA binding; gene silencing by RNA; innate immune response; mRNA processing; metal ion binding; negative regulation of protein kinase activity by regulation of protein phosphorylation; nucleolus; positive regulation of viral genome replication; regulation of transcription, DNA-dependent; response to interferon-alpha; response to virus; supraspliceosomal complex; transcription, DNA-dependent" IPR002466; IPR014720; IPR000607; IPR011991; Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) Adar Dsrad Rattus norvegicus (Rat) TR35924_c6_g1_i3 B4KMZ1 LPHN_DROMO 1.00E-07 GO:0004930; GO:0030246; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; carbohydrate binding; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR000203; IPR000922; Latrophilin Cirl Cirl GI18798 Drosophila mojavensis (Fruit fly) TR35924_c6_g1_i4 O95490 LPHN2_HUMAN 1.00E-09 GO:0004930; GO:0030246; GO:0016021; GO:0016524; GO:0007218; GO:0005886 G-protein coupled receptor activity; carbohydrate binding; integral to membrane; latrotoxin receptor activity; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR001879; IPR003924; IPR003334; IPR000832; IPR017983; IPR000203; IPR000922; IPR003112; Latrophilin-2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Lectomedin-1) LPHN2 KIAA0786 LEC1 LPHH1 Homo sapiens (Human) TR35924_c6_g1_i6 P22031 LEG_ANTCR 3.00E-06 GO:0030246; GO:0005737 carbohydrate binding; cytoplasm IPR000922; D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL) Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR35925_c1_g1_i1 Q8TE56 ATS17_HUMAN 7.00E-57 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; IPR007087; A disintegrin and metalloproteinase with thrombospondin motifs 17 (ADAM-TS 17) (ADAM-TS17) (ADAMTS-17) (EC 3.4.24.-) ADAMTS17 Homo sapiens (Human) TR35925_c1_g1_i2 O15072 ATS3_HUMAN 5.00E-147 GO:0030574; GO:0030199; GO:0008201; GO:0004222; GO:0016485; GO:0005578; GO:0006508; GO:0008270 collagen catabolic process; collagen fibril organization; heparin binding; metalloendopeptidase activity; protein processing; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAM-TS 3) (ADAM-TS3) (ADAMTS-3) (EC 3.4.24.-) (Procollagen II N-proteinase) (PC II-NP) (Procollagen II amino propeptide-processing enzyme) ADAMTS3 KIAA0366 Homo sapiens (Human) TR35927_c0_g1_i1 Q9SJZ5 RAA4E_ARATH 5.00E-08 GO:0005525; GO:0015031; GO:0007264 GTP binding; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Putative Ras-related protein RABA4e (AtRABA4e) RABA4E At2g22390 F14M13.21 Arabidopsis thaliana (Mouse-ear cress) TR35927_c0_g1_i2 Q6IMK3 DJC27_DANRE 2.00E-35 GO:0005525; GO:0007264 GTP binding; small GTPase mediated signal transduction IPR001623; IPR027417; IPR005225; IPR001806; DnaJ homolog subfamily C member 27 (Rab and DnaJ domain-containing protein) dnajc27 rbj Danio rerio (Zebrafish) (Brachydanio rerio) TR35927_c0_g1_i4 P35283 RAB12_MOUSE 6.00E-25 GO:0019003; GO:0005525; GO:0000139; GO:0044257; GO:0008333; GO:0005765; GO:0005764; GO:0015031; GO:0055038; GO:0007264 GDP binding; GTP binding; Golgi membrane; cellular protein catabolic process; endosome to lysosome transport; lysosomal membrane; lysosome; protein transport; recycling endosome membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-12 (Rab-13) Rab12 Mus musculus (Mouse) TR35928_c0_g1_i1 P41774 COX1_MYTED 0 GO:0009060; GO:0004129; GO:0009055; GO:0020037; GO:0016021; GO:0005506; GO:0005743; GO:0006119; GO:0070469 aerobic respiration; cytochrome-c oxidase activity; electron carrier activity; heme binding; integral to membrane; iron ion binding; mitochondrial inner membrane; oxidative phosphorylation; respiratory chain IPR000883; IPR023615; IPR023616; Energy metabolism; oxidative phosphorylation. Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide I) COI Mytilus edulis (Blue mussel) TR35929_c0_g1_i1 P40821 CRJ1C_TRICY 2.00E-45 GO:0005212 structural constituent of eye lens IPR005502; Crystallin J1C Tripedalia cystophora (Jellyfish) TR35929_c0_g1_i3 Q03443 CRJ1B_TRICY 9.00E-18 GO:0005212 structural constituent of eye lens IPR005502; Crystallin J1B Tripedalia cystophora (Jellyfish) TR35930_c4_g1_i2 Q8K0U4 HS12A_MOUSE 3.00E-23 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR35931_c0_g1_i1 Q8BMG8 MFTC_MOUSE 4.00E-117 GO:0016021; GO:0005743; GO:0005739; GO:0006810 integral to membrane; mitochondrial inner membrane; mitochondrion; transport IPR018108; IPR023395; Mitochondrial folate transporter/carrier (Solute carrier family 25 member 32) Slc25a32 Mftc Mus musculus (Mouse) TR35931_c0_g1_i2 P79110 TXTP_BOVIN 1.00E-19 GO:0016021; GO:0005743; GO:0055085 integral to membrane; mitochondrial inner membrane; transmembrane transport IPR002067; IPR018108; IPR023395; "Tricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein)" SLC25A1 SLC20A3 Bos taurus (Bovine) TR35931_c0_g1_i3 O97562 UCP2_PIG 2.00E-17 GO:0016021; GO:0005743; GO:0006839 integral to membrane; mitochondrial inner membrane; mitochondrial transport IPR002030; IPR018108; IPR023395; Mitochondrial uncoupling protein 2 (UCP 2) (Solute carrier family 25 member 8) UCP2 SLC25A8 Sus scrofa (Pig) TR35931_c0_g1_i4 Q6ZT89 S2548_HUMAN 2.00E-13 GO:0016021; GO:0005743; GO:0055085 integral to membrane; mitochondrial inner membrane; transmembrane transport IPR002067; IPR018108; IPR023395; Solute carrier family 25 member 48 SLC25A48 Homo sapiens (Human) TR35932_c8_g2_i2 Q13263 TIF1B_HUMAN 6.00E-07 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR35932_c9_g2_i3 Q924W6 TRI66_MOUSE 2.00E-06 GO:0010369; GO:0045892; GO:0005634; GO:0008270 "chromocenter; negative regulation of transcription, DNA-dependent; nucleus; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR013083; Tripartite motif-containing protein 66 (Transcriptional intermediary factor 1 delta) Trim66 Tif1d Mus musculus (Mouse) TR35933_c2_g1_i1 Q08201 MDR3_RAT 9.00E-31 GO:0005524; GO:0042626; GO:0000139; GO:0016324; GO:0016021; GO:0046581; GO:0042493; GO:0051384; GO:0008559 Q7TSE9 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; Golgi membrane; apical plasma membrane; integral to membrane; intercellular canaliculus; response to drug; response to glucocorticoid stimulus; xenobiotic-transporting ATPase activity" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance protein 3 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 2) (P-glycoprotein 2) (P-glycoprotein 3) Abcb4 Mdr2 Pgp3 Pgy2 Rattus norvegicus (Rat) TR35933_c2_g1_i3 Q08201 MDR3_RAT 4.00E-31 GO:0005524; GO:0042626; GO:0000139; GO:0016324; GO:0016021; GO:0046581; GO:0042493; GO:0051384; GO:0008559 Q7TSE9 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; Golgi membrane; apical plasma membrane; integral to membrane; intercellular canaliculus; response to drug; response to glucocorticoid stimulus; xenobiotic-transporting ATPase activity" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance protein 3 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 2) (P-glycoprotein 2) (P-glycoprotein 3) Abcb4 Mdr2 Pgp3 Pgy2 Rattus norvegicus (Rat) TR35934_c0_g1_i2 P33610 PRI2_MOUSE 4.00E-168 GO:0051539; GO:0003677; GO:0003896; GO:0046872; GO:1990077 "4 iron, 4 sulfur cluster binding; DNA binding; DNA primase activity; metal ion binding; primosome complex" IPR016558; IPR007238; DNA primase large subunit (EC 2.7.7.-) (DNA primase 58 kDa subunit) (p58) Prim2 Mus musculus (Mouse) TR35936_c4_g1_i2 Q6P8Y1 CAPSL_MOUSE 3.00E-77 GO:0005509; GO:0005737 calcium ion binding; cytoplasm IPR011992; IPR018247; IPR002048; IPR001125; Calcyphosin-like protein Capsl Mus musculus (Mouse) TR35936_c4_g1_i3 Q9GKR6 CAYP2_MACFA 2.00E-19 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calcyphosin-2 (Calcyphosine-2) CAPS2 QnpA-21934 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR35936_c4_g1_i4 Q9C6P3 CDPKX_ARATH 8.00E-08 GO:0005524; GO:0005509; GO:0005886; GO:0004674 ATP binding; calcium ion binding; plasma membrane; protein serine/threonine kinase activity IPR011992; IPR018247; IPR002048; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium-dependent protein kinase 33 (EC 2.7.11.1) CPK33 At1g50700 F17J6.22 Arabidopsis thaliana (Mouse-ear cress) TR35936_c4_g1_i5 Q6P8Y1 CAPSL_MOUSE 4.00E-77 GO:0005509; GO:0005737 calcium ion binding; cytoplasm IPR011992; IPR018247; IPR002048; IPR001125; Calcyphosin-like protein Capsl Mus musculus (Mouse) TR35936_c4_g1_i6 Q9BXY5 CAYP2_HUMAN 5.00E-10 GO:0005509 calcium ion binding IPR011992; IPR002048; Calcyphosin-2 (Calcyphosine-2) CAPS2 UG0636c06 Homo sapiens (Human) TR35936_c5_g1_i1 Q7XYT0 FPPS2_ARTSI 4.00E-110 GO:0004161; GO:0045337; GO:0033384; GO:0004337; GO:0046872 dimethylallyltranstransferase activity; farnesyl diphosphate biosynthetic process; geranyl diphosphate biosynthetic process; geranyltranstransferase activity; metal ion binding IPR000092; IPR008949; Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1. Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1. "Farnesyl diphosphate synthase 2 [Includes: Dimethylallyltranstransferase (EC 2.5.1.1); (2E,6E)-farnesyl diphosphate synthase (EC 2.5.1.10)]" FDS-2 Artemisia spiciformis (Spiked big sagebrush) (Artemisia tridentata spiciformis) TR35936_c5_g1_i5 P08836 FPPS_CHICK 4.00E-138 GO:0006695; GO:0005737; GO:0004161; GO:0045337; GO:0033384; GO:0004337; GO:0046872 cholesterol biosynthetic process; cytoplasm; dimethylallyltranstransferase activity; farnesyl diphosphate biosynthetic process; geranyl diphosphate biosynthetic process; geranyltranstransferase activity; metal ion binding IPR000092; IPR008949; Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1. Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1. "Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase)" FDPS Gallus gallus (Chicken) TR35937_c0_g1_i1 P09411 PGK1_MOUSE 0 GO:0005524; GO:0005737; GO:0006096; GO:0004618 ATP binding; cytoplasm; glycolysis; phosphoglycerate kinase activity IPR001576; IPR015901; IPR015911; IPR015824; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. Phosphoglycerate kinase 1 (EC 2.7.2.3) Pgk1 Pgk-1 Mus musculus (Mouse) TR35938_c1_g1_i2 Q95107 WASL_BOVIN 2.00E-62 GO:0030478; GO:0007015; GO:0051301; GO:0034629; GO:0030027; GO:0007067; GO:0005634; GO:2000601; GO:0032880; GO:0006355; GO:0009617; GO:0051653; GO:0006351 Itself; A7MB62; Q60598 "actin cap; actin filament organization; cell division; cellular protein complex localization; lamellipodium; mitosis; nucleus; positive regulation of Arp2/3 complex-mediated actin nucleation; regulation of protein localization; regulation of transcription, DNA-dependent; response to bacterium; spindle localization; transcription, DNA-dependent" IPR000095; IPR011993; IPR027641; IPR011026; IPR000697; IPR003124; Neural Wiskott-Aldrich syndrome protein (N-WASP) WASL Bos taurus (Bovine) TR35938_c1_g1_i6 O08816 WASL_RAT 3.00E-62 GO:0000139; GO:0007015; GO:0051301; GO:0016023; GO:0005856; GO:0005829; GO:0006900; GO:0010324; GO:0097320; GO:0007067; GO:0005634; GO:2000601; GO:2000370; GO:0051491; GO:0006355; GO:0006351; GO:0030050 Itself; P60953; Q8IVI9; P07737; P35080; Q6IN36 "Golgi membrane; actin filament organization; cell division; cytoplasmic membrane-bounded vesicle; cytoskeleton; cytosol; membrane budding; membrane invagination; membrane tubulation; mitosis; nucleus; positive regulation of Arp2/3 complex-mediated actin nucleation; positive regulation of clathrin-mediated endocytosis; positive regulation of filopodium assembly; regulation of transcription, DNA-dependent; transcription, DNA-dependent; vesicle transport along actin filament" IPR000095; IPR011993; IPR027641; IPR011026; IPR000697; IPR003124; Neural Wiskott-Aldrich syndrome protein (N-WASP) Wasl Rattus norvegicus (Rat) TR35940_c0_g1_i1 H2A0N9 KCP4_PINMG 4.00E-17 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR004094; IPR011061; IPR002223; IPR020901; BPTI/Kunitz domain-containing protein 4 (Nacre serine protease inhibitor 3) (NSPI3) Pinctada margaritifera (Black-lipped pearl oyster) TR35940_c0_g1_i2 A5X2X1 IVBI_SISCA 8.00E-15 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; IPR008197; Fused toxin protein Sistrurus catenatus edwardsii (Desert massasauga) (Crotalophorus edwardsii) TR35940_c0_g1_i3 Q9TWF8 KC3_ANESU 6.00E-16 GO:0005576; GO:0042151; GO:0004867 extracellular region; nematocyst; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Kunitz-type proteinase inhibitor kalicludin-3 (AsKC3) (Kalicludine-3) Anemonia sulcata (Mediterranean snakelocks sea anemone) (Anemonia viridis) TR35941_c2_g1_i1 Q804Q2 OPN4B_GADMO 1.00E-14 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR027430; Melanopsin-B (Opsin-4B) opn4b Gadus morhua (Atlantic cod) TR35941_c2_g1_i4 B3DM66 GP161_XENTR 2.00E-18 GO:0004930; GO:0060170; GO:0016021; GO:0007275; GO:1901621; GO:0030819; GO:0072372; GO:0055037 G-protein coupled receptor activity; cilium membrane; integral to membrane; multicellular organismal development; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; positive regulation of cAMP biosynthetic process; primary cilium; recycling endosome IPR000276; IPR017452; G-protein coupled receptor 161 gpr161 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35941_c4_g1_i1 P22792 CPN2_HUMAN 5.00E-14 GO:0030234; GO:0005576; GO:0050821 enzyme regulator activity; extracellular region; protein stabilization IPR000483; IPR001611; IPR025875; IPR003591; IPR000372; Carboxypeptidase N subunit 2 (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N large subunit) (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N regulatory subunit) CPN2 ACBP Homo sapiens (Human) TR35941_c4_g1_i2 Q9CXD9 LRC17_MOUSE 3.00E-09 GO:0048539; GO:0005615; GO:0045671; GO:0001503 bone marrow development; extracellular space; negative regulation of osteoclast differentiation; ossification IPR000483; IPR001611; Leucine-rich repeat-containing protein 17 Lrrc17 Mus musculus (Mouse) TR35942_c0_g1_i1 P24367 PPIB_CHICK 8.00E-80 GO:0005788; GO:0042277; GO:0003755; GO:0006457; GO:0000413 endoplasmic reticulum lumen; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB Gallus gallus (Chicken) TR35942_c0_g1_i2 Q6GLX7 CWC27_XENLA 1.00E-14 GO:0003755; GO:0006457; GO:0000413 peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR020892; Peptidyl-prolyl cis-trans isomerase CWC27 homolog (PPIase CWC27) (EC 5.2.1.8) cwc27 sdccag10 Xenopus laevis (African clawed frog) TR35942_c0_g1_i3 Q8X166 PPIB_ASPNG 1.00E-66 GO:0005788; GO:0042277; GO:0003755; GO:0006457; GO:0000413 endoplasmic reticulum lumen; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Rotamase B) cypB Aspergillus niger TR35943_c2_g1_i1 A9ULZ2 BIR7B_XENLA 2.00E-40 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) TR35943_c2_g1_i2 A9ULZ2 BIR7B_XENLA 2.00E-40 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) TR35943_c2_g1_i3 Q13489 BIRC3_HUMAN 2.00E-16 GO:0038061; GO:0035666; GO:0006915; GO:0007166; GO:0005829; GO:0045087; GO:0070266; GO:0043066; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0043123; GO:0039535; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0034138; GO:0034142; GO:0004842; GO:0008270 Q13546; O43353; Q9Y572; P57078; Q12933 NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; apoptotic process; cell surface receptor signaling pathway; cytosol; innate immune response; necroptosis; negative regulation of apoptotic process; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of RIG-I signaling pathway; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Apoptosis inhibitor 2) (API2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (IAP-1) (hIAP-1) (hIAP1) (RING finger protein 49) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 IAP1 MIHC RNF49 Homo sapiens (Human) TR35943_c4_g1_i1 Q8JHV9 BIR7A_XENLA 6.00E-31 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR35943_c4_g1_i4 Q8JHV9 BIR7A_XENLA 1.00E-30 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR35943_c4_g2_i1 O62640 PIAP_PIG 2.00E-19 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR35943_c4_g3_i3 Q24307 IAP2_DROME 3.00E-17 GO:0050829; GO:0043066; GO:0043154; GO:0061057; GO:0006964; GO:0033160; GO:0070534; GO:0007423; GO:0008270 "defense response to Gram-negative bacterium; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; peptidoglycan recognition protein signaling pathway; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; positive regulation of protein import into nucleus, translocation; protein K63-linked ubiquitination; sensory organ development; zinc ion binding" IPR001370; IPR001841; IPR013083; Apoptosis 2 inhibitor (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) (dIAP2) Iap2 DIHA ILP CG8293 Drosophila melanogaster (Fruit fly) TR35943_c4_g3_i5 A9ULZ2 BIR7B_XENLA 7.00E-33 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) TR35944_c2_g1_i1 P24322 GGPPS_NEUCR 2.00E-104 GO:0016117; GO:0005737; GO:0004161; GO:0045337; GO:0004311; GO:0033384; GO:0033386; GO:0004337; GO:0006720; GO:0046872 carotenoid biosynthetic process; cytoplasm; dimethylallyltranstransferase activity; farnesyl diphosphate biosynthetic process; farnesyltranstransferase activity; geranyl diphosphate biosynthetic process; geranylgeranyl diphosphate biosynthetic process; geranyltranstransferase activity; isoprenoid metabolic process; metal ion binding IPR000092; IPR017446; IPR008949; Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1. Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1. Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1. "Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Albino-3 protein) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)" al-3 B8P8.010 NCU01427 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR35944_c2_g1_i2 P56966 GGPPS_BOVIN 1.00E-147 GO:0005737; GO:0004161; GO:0045337; GO:0004311; GO:0033384; GO:0033386; GO:0004337; GO:0006720; GO:0046872 cytoplasm; dimethylallyltranstransferase activity; farnesyl diphosphate biosynthetic process; farnesyltranstransferase activity; geranyl diphosphate biosynthetic process; geranylgeranyl diphosphate biosynthetic process; geranyltranstransferase activity; isoprenoid metabolic process; metal ion binding IPR000092; IPR017446; IPR008949; Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1. Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1. Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1. "Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)" GGPS1 Bos taurus (Bovine) TR35944_c2_g1_i3 P56966 GGPPS_BOVIN 5.00E-134 GO:0005737; GO:0004161; GO:0045337; GO:0004311; GO:0033384; GO:0033386; GO:0004337; GO:0006720; GO:0046872 cytoplasm; dimethylallyltranstransferase activity; farnesyl diphosphate biosynthetic process; farnesyltranstransferase activity; geranyl diphosphate biosynthetic process; geranylgeranyl diphosphate biosynthetic process; geranyltranstransferase activity; isoprenoid metabolic process; metal ion binding IPR000092; IPR017446; IPR008949; Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1. Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1. Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1. "Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)" GGPS1 Bos taurus (Bovine) TR35946_c0_g1_i1 B2GUS6 KDM8_XENTR 1.00E-15 GO:0000086; GO:0003682; GO:0051864; GO:0046872; GO:0005634; GO:0045893; GO:0006351 "G2/M transition of mitotic cell cycle; chromatin binding; histone demethylase activity (H3-K36 specific); metal ion binding; nucleus; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003347; Lysine-specific demethylase 8 (EC 1.14.11.27) (JmjC domain-containing protein 5) (Jumonji domain-containing protein 5) kdm8 jmjd5 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35946_c0_g1_i2 Q96EW2 HBAP1_HUMAN 1.00E-83 GO:0005737 cytoplasm IPR013296; IPR003347; HSPB1-associated protein 1 (27 kDa heat shock protein-associated protein 1) (Protein associated with small stress protein 1) HSPBAP1 PASS1 Homo sapiens (Human) TR35946_c0_g1_i3 A2RUC4 TYW5_HUMAN 8.00E-11 GO:0005506; GO:0016706; GO:0042803; GO:0000049; GO:0031591 "iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; protein homodimerization activity; tRNA binding; wybutosine biosynthetic process" IPR003347; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. tRNA wybutosine-synthesizing protein 5 (hTYW5) (EC 1.14.11.42) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase) TYW5 C2orf60 Homo sapiens (Human) TR35946_c0_g1_i4 Q55DF5 JMJCD_DICDI 7.00E-15 IPR003347; JmjC domain-containing protein D (Jumonji domain-containing protein D) jcdD DDB_G0270906 Dictyostelium discoideum (Slime mold) TR35946_c0_g1_i5 B2GUS6 KDM8_XENTR 2.00E-15 GO:0000086; GO:0003682; GO:0051864; GO:0046872; GO:0005634; GO:0045893; GO:0006351 "G2/M transition of mitotic cell cycle; chromatin binding; histone demethylase activity (H3-K36 specific); metal ion binding; nucleus; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003347; Lysine-specific demethylase 8 (EC 1.14.11.27) (JmjC domain-containing protein 5) (Jumonji domain-containing protein 5) kdm8 jmjd5 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR35946_c0_g1_i7 Q96EW2 HBAP1_HUMAN 4.00E-84 GO:0005737 cytoplasm IPR013296; IPR003347; HSPB1-associated protein 1 (27 kDa heat shock protein-associated protein 1) (Protein associated with small stress protein 1) HSPBAP1 PASS1 Homo sapiens (Human) TR35946_c0_g1_i8 A2RUC4 TYW5_HUMAN 8.00E-11 GO:0005506; GO:0016706; GO:0042803; GO:0000049; GO:0031591 "iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; protein homodimerization activity; tRNA binding; wybutosine biosynthetic process" IPR003347; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. tRNA wybutosine-synthesizing protein 5 (hTYW5) (EC 1.14.11.42) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase) TYW5 C2orf60 Homo sapiens (Human) TR35947_c0_g1_i1 P91929 NDUAA_DROME 2.00E-43 GO:0005524; GO:0005811; GO:0005759; GO:0005739; GO:0006139; GO:0055114; GO:0016773; GO:0070469 "ATP binding; lipid particle; mitochondrial matrix; mitochondrion; nucleobase-containing compound metabolic process; oxidation-reduction process; phosphotransferase activity, alcohol group as acceptor; respiratory chain" IPR002624; IPR015828; IPR027417; "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (Complex I-42kD) (CI-42kD) (NADH-ubiquinone oxidoreductase 42 kDa subunit)" ND42 CG6343 Drosophila melanogaster (Fruit fly) TR3595_c0_g1_i1 Q12829 RB40B_HUMAN 4.00E-07 GO:0005525; GO:0005886; GO:0015031; GO:0016567; GO:0007264 GTP binding; plasma membrane; protein transport; protein ubiquitination; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; IPR001496; Protein modification; protein ubiquitination. Ras-related protein Rab-40B (SOCS box-containing protein RAR) (Protein Rar) RAB40B SEC4L Homo sapiens (Human) TR3595_c0_g1_i2 Q03206 RAC1_CAEEL 2.00E-38 GO:0005525; GO:0003924; GO:0006915; GO:0048846; GO:0031103; GO:0010171; GO:0009986; GO:0031410; GO:0005829; GO:0033563; GO:0043652; GO:0016021; GO:0009898; GO:0008045; GO:0002119; GO:0001764; GO:0030334; GO:0050764; GO:0007264 GTP binding; GTPase activity; apoptotic process; axon extension involved in axon guidance; axon regeneration; body morphogenesis; cell surface; cytoplasmic vesicle; cytosol; dorsal/ventral axon guidance; engulfment of apoptotic cell; integral to membrane; internal side of plasma membrane; motor neuron axon guidance; nematode larval development; neuron migration; regulation of cell migration; regulation of phagocytosis; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Ras-related protein ced-10 (CErac1) (Cell death protein 10) (Cell-corpse engulfment protein ced-10) (Ras-related protein rac-1) ced-10 rac-1 C09G12.8 Caenorhabditis elegans TR35954_c3_g2_i1 Q95LU3 FBCD1_MACFA 4.00E-67 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR35954_c3_g2_i2 Q5I2E5 FCN2_BOVIN 7.00E-61 GO:0005581; GO:0001867 "collagen; complement activation, lectin pathway" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) FCN2 Bos taurus (Bovine) TR35956_c0_g3_i1 Q99L04 DHRS1_MOUSE 3.00E-86 GO:0005783; GO:0005743; GO:0016491 endoplasmic reticulum; mitochondrial inner membrane; oxidoreductase activity IPR002198; IPR002347; IPR016040; Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-) Dhrs1 D14ertd484e Mus musculus (Mouse) TR35956_c0_g3_i2 P71079 FABL_BACSU 3.00E-22 GO:0050661; GO:0004318; GO:0047117; GO:0030497; GO:0051289 "NADP binding; enoyl-[acyl-carrier-protein] reductase (NADH) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; fatty acid elongation; protein homotetramerization" IPR002198; IPR002347; IPR016040; Lipid metabolism; fatty acid biosynthesis. Enoyl-[acyl-carrier-protein] reductase [NADPH] FabL (ENR) (EC 1.3.1.104) (Enoyl-acyl carrier protein reductase III) (NADPH-dependent enoyl-ACP reductase) fabL yfhR ygaA BSU08650 Bacillus subtilis (strain 168) TR35957_c1_g1_i1 Q642M9 DHDH_DANRE 3.00E-78 GO:0047837; GO:0047115 "D-xylose 1-dehydrogenase (NADP+) activity; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity" IPR016040; IPR000683; IPR004104; "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) (D-xylose 1-dehydrogenase) (D-xylose-NADP dehydrogenase) (EC 1.1.1.179) (Dimeric dihydrodiol dehydrogenase)" dhdh ch211-203b17.3 zgc:101723 Danio rerio (Zebrafish) (Brachydanio rerio) TR35957_c1_g1_i2 Q6DKE0 DHDH_XENLA 2.00E-78 GO:0047837; GO:0047115 "D-xylose 1-dehydrogenase (NADP+) activity; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity" IPR016040; IPR000683; "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) (D-xylose 1-dehydrogenase) (D-xylose-NADP dehydrogenase) (EC 1.1.1.179) (Dimeric dihydrodiol dehydrogenase)" dhdh Xenopus laevis (African clawed frog) TR35957_c1_g1_i3 P49305 YMO1_RHIML 3.00E-31 GO:0016491 oxidoreductase activity IPR016040; IPR000683; IPR004104; Uncharacterized oxidoreductase ORF334 (EC 1.-.-.-) Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) TR35958_c4_g3_i1 Q9BX70 BTBD2_HUMAN 4.00E-12 GO:0000932 Q7L5N1; P04637 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) TR35959_c5_g1_i3 O80322 RNS1_PYRPY 5.00E-17 GO:0003723; GO:0090305; GO:0033897 RNA binding; nucleic acid phosphodiester bond hydrolysis; ribonuclease T2 activity IPR001568; IPR018188; Ribonuclease S-1 (EC 3.1.27.1) (S1-RNase) Pyrus pyrifolia (Chinese pear) (Pyrus serotina) TR35959_c6_g2_i1 Q7M456 RNOY_CRAGI 7.00E-26 GO:0003723; GO:0005576; GO:0090305; GO:0033897 RNA binding; extracellular region; nucleic acid phosphodiester bond hydrolysis; ribonuclease T2 activity IPR001568; IPR018188; Ribonuclease Oy (RNase Oy) (EC 3.1.27.-) Crassostrea gigas (Pacific oyster) (Crassostrea angulata) TR3596_c0_g2_i1 P30937 SSR4_RAT 2.00E-09 GO:0019369; GO:0016477; GO:0071385; GO:0005737; GO:0030900; GO:0016021; GO:0030815; GO:0005886; GO:0043410; GO:0004994 P31016 arachidonic acid metabolic process; cell migration; cellular response to glucocorticoid stimulus; cytoplasm; forebrain development; integral to membrane; negative regulation of cAMP metabolic process; plasma membrane; positive regulation of MAPK cascade; somatostatin receptor activity IPR000276; IPR017452; IPR000586; IPR001512; Somatostatin receptor type 4 (SS-4-R) (SS4-R) (SS4R) Sstr4 Rattus norvegicus (Rat) TR35960_c1_g1_i2 P49165 RL4_URECA 0 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR025755; IPR002136; IPR013000; IPR023574; 60S ribosomal protein L4 (L1) RPL4 RPL1 Urechis caupo (Innkeeper worm) (Spoonworm) TR35961_c1_g1_i2 A5D7H5 CASC3_BOVIN 8.00E-26 GO:0003723; GO:0008380; GO:0035145; GO:0008298; GO:0006397; GO:0051028; GO:0016607; GO:0000184; GO:0048471; GO:0006417; GO:0006950; GO:0030529 "RNA binding; RNA splicing; exon-exon junction complex; intracellular mRNA localization; mRNA processing; mRNA transport; nuclear speck; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; perinuclear region of cytoplasm; regulation of translation; response to stress; ribonucleoprotein complex" IPR018545; Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein homolog) (MLN 51 homolog) (Protein barentsz) (Btz) CASC3 MLN51 Bos taurus (Bovine) TR35961_c2_g2_i1 Q8IV35 WDR49_HUMAN 6.00E-47 IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 49 WDR49 Homo sapiens (Human) TR35962_c10_g1_i1 Q4ULZ2 Y580_RICFE 2.00E-16 IPR002110; IPR020683; Putative ankyrin repeat protein RF_0580 RF_0580 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR35962_c6_g1_i1 Q3SZZ7 FGL1_BOVIN 2.00E-52 GO:0005576 extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein 1 FGL1 Bos taurus (Bovine) TR35962_c6_g3_i1 E2IYB3 FCNV1_VARKO 1.00E-09 GO:0005576 extracellular region IPR008160; IPR014716; IPR002181; Veficolin-1 (Fragment) Varanus komodoensis (Komodo dragon) TR35962_c9_g1_i3 Q8T112 CBPH_APLCA 8.00E-06 GO:0005576 extracellular region Cerebrin prohormone [Cleaved into: Cerebrin] CBPH Aplysia californica (California sea hare) TR35964_c0_g1_i1 Q8IYH5 ZZZ3_HUMAN 5.00E-98 GO:0005671; GO:0003677; GO:0003682; GO:0006355; GO:0006351; GO:0008270 P09022; Q92830 "Ada2/Gcn5/Ada3 transcription activator complex; DNA binding; chromatin binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR009057; IPR017930; IPR001005; IPR000433; ZZ-type zinc finger-containing protein 3 ZZZ3 Homo sapiens (Human) TR35964_c0_g1_i5 Q8IYH5 ZZZ3_HUMAN 3.00E-98 GO:0005671; GO:0003677; GO:0003682; GO:0006355; GO:0006351; GO:0008270 P09022; Q92830 "Ada2/Gcn5/Ada3 transcription activator complex; DNA binding; chromatin binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR009057; IPR017930; IPR001005; IPR000433; ZZ-type zinc finger-containing protein 3 ZZZ3 Homo sapiens (Human) TR35966_c4_g3_i2 Q9UPM8 AP4E1_HUMAN 3.00E-88 GO:0005794; GO:0006886; GO:0030117; GO:0016192 Golgi apparatus; intracellular protein transport; membrane coat; vesicle-mediated transport IPR017109; IPR028269; IPR011989; IPR016024; IPR002553; AP-4 complex subunit epsilon-1 (AP-4 adapter complex subunit epsilon) (Adapter-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) AP4E1 Homo sapiens (Human) TR35966_c4_g6_i1 Q08951 AP3D_YEAST 1.00E-08 GO:0030123; GO:0005794; GO:0006896; GO:0030665; GO:0006623; GO:0008565 P46682; P38153 AP-3 adaptor complex; Golgi apparatus; Golgi to vacuole transport; clathrin-coated vesicle membrane; protein targeting to vacuole; protein transporter activity IPR017105; IPR011989; IPR016024; IPR002553; AP-3 complex subunit delta (Adapter-related protein complex 3 subunit delta) (Delta-adaptin 3) (Delta-adaptin) APL5 YKS4 YPL195W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR35967_c2_g1_i1 P02594 CALM_ELEEL 1.00E-98 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) calm Electrophorus electricus (Electric eel) TR35967_c2_g1_i2 Q66H96 CABP7_RAT 5.00E-18 GO:0005794; GO:0005509; GO:0016021; GO:0048471; GO:0005886; GO:0032588 Golgi apparatus; calcium ion binding; integral to membrane; perinuclear region of cytoplasm; plasma membrane; trans-Golgi network membrane IPR011992; IPR018247; IPR002048; IPR001751; Calcium-binding protein 7 (CaBP7) (Calneuron II) (Calneuron-2) Cabp7 Caln2 Rattus norvegicus (Rat) TR35967_c2_g2_i1 Q9XZP2 CALM2_BRAFL 1.00E-94 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-2 (CaM 2) CAM2 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR35967_c2_g2_i2 P81660 TNNC2_ANGAN 2.00E-32 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; "Troponin C, skeletal muscle (TNC)" Anguilla anguilla (European freshwater eel) (Muraena anguilla) TR35967_c3_g1_i1 Q7XHW4 CML24_ORYSJ 1.00E-10 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Probable calcium-binding protein CML24 (Calmodulin-like protein 24) CML24 Os07g0681400 LOC_Os07g48340 OsJ_024595 OSJNBa0008J01.24 Oryza sativa subsp. japonica (Rice) TR35967_c3_g1_i2 Q95NR9 CALM_METSE 1.00E-68 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Metridium senile (Brown sea anemone) (Frilled sea anemone) TR35967_c4_g1_i1 Q9LX27 CML4_ARATH 2.00E-13 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-like protein 4 CML4 At3g59440 F25L23.300 Arabidopsis thaliana (Mouse-ear cress) TR35968_c1_g1_i1 A1SGG5 SYM_NOCSJ 2.00E-11 GO:0005524; GO:0005737; GO:0046872; GO:0004825; GO:0006431 ATP binding; cytoplasm; metal ion binding; methionine-tRNA ligase activity; methionyl-tRNA aminoacylation IPR023458; IPR014758; IPR015413; IPR014729; IPR009080; Methionine--tRNA ligase (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) metG Noca_1386 Nocardioides sp. (strain BAA-499 / JS614) TR35968_c1_g2_i1 Q7T0Z0 SYMM_XENLA 6.00E-118 GO:0005524; GO:0004825; GO:0006431; GO:0005759 ATP binding; methionine-tRNA ligase activity; methionyl-tRNA aminoacylation; mitochondrial matrix IPR014758; IPR015413; IPR014729; IPR009080; "Methionine--tRNA ligase, mitochondrial (EC 6.1.1.10) (Methionyl-tRNA synthetase 2) (Mitochondrial methionyl-tRNA synthetase) (MtMetRS)" mars2 Xenopus laevis (African clawed frog) TR35970_c2_g1_i2 Q9ULK6 RN150_HUMAN 2.00E-66 GO:0016021; GO:0008270 integral to membrane; zinc ion binding IPR003137; IPR001841; IPR013083; RING finger protein 150 RNF150 KIAA1214 Homo sapiens (Human) TR35971_c0_g1_i1 Q0VCI6 PIHD1_BOVIN 3.00E-56 IPR012981; PIH1 domain-containing protein 1 PIH1D1 Bos taurus (Bovine) TR35971_c0_g1_i2 Q7ZWY2 PIHD1_XENLA 2.00E-87 IPR012981; PIH1 domain-containing protein 1 pih1d1 Xenopus laevis (African clawed frog) TR35972_c5_g1_i1 A2A9C3 SZT2_MOUSE 1.00E-33 GO:0007417; GO:0005777; GO:0043473; GO:0009791 central nervous system development; peroxisome; pigmentation; post-embryonic development Protein SZT2 (Seizure threshold 2 protein) (Transcript increased in glutamate resistance) (TIGR) Szt2 Mus musculus (Mouse) TR35972_c7_g1_i1 Q5T011 SZT2_HUMAN 2.00E-31 GO:0007417; GO:0005777; GO:0043473; GO:0009791 central nervous system development; peroxisome; pigmentation; post-embryonic development Protein SZT2 (Seizure threshold 2 protein homolog) SZT2 C1orf84 KIAA0467 Homo sapiens (Human) TR35974_c0_g1_i1 Q1RM35 CC104_DANRE 3.00E-21 IPR023379; Coiled-coil domain-containing protein 104 ccdc104 zgc:136497 Danio rerio (Zebrafish) (Brachydanio rerio) TR35974_c3_g1_i3 Q0P5B1 PEX13_BOVIN 2.00E-69 GO:0021795; GO:0001561; GO:0005779; GO:0007626; GO:0060152; GO:0001764; GO:0016560; GO:0001967 "cerebral cortex cell migration; fatty acid alpha-oxidation; integral to peroxisomal membrane; locomotory behavior; microtubule-based peroxisome localization; neuron migration; protein import into peroxisome matrix, docking; suckling behavior" IPR007223; IPR001452; Peroxisomal membrane protein PEX13 (Peroxin-13) PEX13 Bos taurus (Bovine) TR35975_c0_g1_i4 O95210 STBD1_HUMAN 2.00E-08 GO:0005887; GO:0006936; GO:2001070 O95166; Q9H0R8; P60520; Q9GZQ8 integral to plasma membrane; muscle contraction; starch binding IPR013784; IPR002044; IPR013783; Starch-binding domain-containing protein 1 (Genethonin-1) STBD1 GENX-3414 Homo sapiens (Human) TR35976_c0_g1_i1 Q90871 IRF8_CHICK 7.00E-42 GO:0071222; GO:0042742; GO:0042832; GO:0006955; GO:0030099; GO:0044130; GO:0005634; GO:0006909; GO:0032729; GO:0032735; GO:0060261; GO:0000975; GO:0003700; GO:0006351 "cellular response to lipopolysaccharide; defense response to bacterium; defense response to protozoan; immune response; myeloid cell differentiation; negative regulation of growth of symbiont in host; nucleus; phagocytosis; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; positive regulation of transcription initiation from RNA polymerase II promoter; regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR019817; IPR001346; IPR019471; IPR017855; IPR008984; IPR011991; Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (ICSBP) IRF8 ICSBP ICSBP1 Gallus gallus (Chicken) TR35977_c1_g1_i2 Q96495 ORM1_SACMO 8.00E-19 GO:0016021 integral to membrane IPR007203; Protein ORM1 ORM1 Saccharomyces monacensis (Yeast) TR35977_c1_g1_i3 Q29RQ9 ORML1_BOVIN 7.00E-58 GO:0006672; GO:0005789; GO:0016021 ceramide metabolic process; endoplasmic reticulum membrane; integral to membrane IPR007203; ORM1-like protein 1 ORMDL1 Bos taurus (Bovine) TR35978_c0_g1_i1 Q8K4K7 ABRA_RAT 2.00E-24 GO:0003779; GO:0015629; GO:0005886; GO:0035025; GO:0051091; GO:0045944; GO:0000060; GO:0030017; GO:0003713; GO:0006351 "actin binding; actin cytoskeleton; plasma membrane; positive regulation of Rho protein signal transduction; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein import into nucleus, translocation; sarcomere; transcription coactivator activity; transcription, DNA-dependent" IPR026111; IPR027817; Actin-binding Rho-activating protein (MS1) (Striated muscle activator of Rho-dependent signaling) (STARS) Abra Ms1 Rattus norvegicus (Rat) TR35978_c0_g1_i15 Q8K4K7 ABRA_RAT 2.00E-24 GO:0003779; GO:0015629; GO:0005886; GO:0035025; GO:0051091; GO:0045944; GO:0000060; GO:0030017; GO:0003713; GO:0006351 "actin binding; actin cytoskeleton; plasma membrane; positive regulation of Rho protein signal transduction; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein import into nucleus, translocation; sarcomere; transcription coactivator activity; transcription, DNA-dependent" IPR026111; IPR027817; Actin-binding Rho-activating protein (MS1) (Striated muscle activator of Rho-dependent signaling) (STARS) Abra Ms1 Rattus norvegicus (Rat) TR35978_c0_g1_i17 Q8K4K7 ABRA_RAT 2.00E-24 GO:0003779; GO:0015629; GO:0005886; GO:0035025; GO:0051091; GO:0045944; GO:0000060; GO:0030017; GO:0003713; GO:0006351 "actin binding; actin cytoskeleton; plasma membrane; positive regulation of Rho protein signal transduction; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein import into nucleus, translocation; sarcomere; transcription coactivator activity; transcription, DNA-dependent" IPR026111; IPR027817; Actin-binding Rho-activating protein (MS1) (Striated muscle activator of Rho-dependent signaling) (STARS) Abra Ms1 Rattus norvegicus (Rat) TR35978_c0_g1_i19 Q8K4K7 ABRA_RAT 2.00E-24 GO:0003779; GO:0015629; GO:0005886; GO:0035025; GO:0051091; GO:0045944; GO:0000060; GO:0030017; GO:0003713; GO:0006351 "actin binding; actin cytoskeleton; plasma membrane; positive regulation of Rho protein signal transduction; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein import into nucleus, translocation; sarcomere; transcription coactivator activity; transcription, DNA-dependent" IPR026111; IPR027817; Actin-binding Rho-activating protein (MS1) (Striated muscle activator of Rho-dependent signaling) (STARS) Abra Ms1 Rattus norvegicus (Rat) TR35978_c0_g1_i3 Q8K4K7 ABRA_RAT 2.00E-24 GO:0003779; GO:0015629; GO:0005886; GO:0035025; GO:0051091; GO:0045944; GO:0000060; GO:0030017; GO:0003713; GO:0006351 "actin binding; actin cytoskeleton; plasma membrane; positive regulation of Rho protein signal transduction; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein import into nucleus, translocation; sarcomere; transcription coactivator activity; transcription, DNA-dependent" IPR026111; IPR027817; Actin-binding Rho-activating protein (MS1) (Striated muscle activator of Rho-dependent signaling) (STARS) Abra Ms1 Rattus norvegicus (Rat) TR35978_c0_g2_i1 Q8BUZ1 ABRA_MOUSE 2.00E-29 GO:0003779; GO:0015629; GO:0005886; GO:0035025; GO:0051091; GO:0045944; GO:0000060; GO:0030017; GO:0003713; GO:0006351 "actin binding; actin cytoskeleton; plasma membrane; positive regulation of Rho protein signal transduction; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein import into nucleus, translocation; sarcomere; transcription coactivator activity; transcription, DNA-dependent" IPR026111; IPR027817; Actin-binding Rho-activating protein (Striated muscle activator of Rho-dependent signaling) (STARS) Abra Mus musculus (Mouse) TR35978_c0_g2_i2 Q8BUZ1 ABRA_MOUSE 7.00E-30 GO:0003779; GO:0015629; GO:0005886; GO:0035025; GO:0051091; GO:0045944; GO:0000060; GO:0030017; GO:0003713; GO:0006351 "actin binding; actin cytoskeleton; plasma membrane; positive regulation of Rho protein signal transduction; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein import into nucleus, translocation; sarcomere; transcription coactivator activity; transcription, DNA-dependent" IPR026111; IPR027817; Actin-binding Rho-activating protein (Striated muscle activator of Rho-dependent signaling) (STARS) Abra Mus musculus (Mouse) TR35979_c0_g1_i1 Q8K409 DPOLB_MOUSE 1.00E-150 GO:0006260; GO:0003887; GO:0006287; GO:0005737; GO:0003684; GO:0008630; GO:0016829; GO:0046872; GO:0008017; GO:0051402; GO:0006290; GO:0045471; GO:0005876; GO:0000795 "DNA replication; DNA-directed DNA polymerase activity; base-excision repair, gap-filling; cytoplasm; damaged DNA binding; intrinsic apoptotic signaling pathway in response to DNA damage; lyase activity; metal ion binding; microtubule binding; neuron apoptotic process; pyrimidine dimer repair; response to ethanol; spindle microtubule; synaptonemal complex" IPR002054; IPR019843; IPR010996; IPR028207; IPR018944; IPR022312; IPR002008; IPR003583; IPR027420; DNA polymerase beta (EC 2.7.7.7) (EC 4.2.99.-) Polb Mus musculus (Mouse) TR35979_c0_g1_i3 O02789 TDT_MONDO 6.00E-13 GO:0003677; GO:0006304; GO:0003912; GO:0003887; GO:0046872; GO:0005634 DNA binding; DNA modification; DNA nucleotidylexotransferase activity; DNA-directed DNA polymerase activity; metal ion binding; nucleus IPR001357; IPR002054; IPR019843; IPR010996; IPR028207; IPR018944; IPR022312; IPR027421; IPR027292; IPR001726; DNA nucleotidylexotransferase (EC 2.7.7.31) (Terminal addition enzyme) (Terminal deoxynucleotidyltransferase) (TDT) (Terminal transferase) DNTT TDT Monodelphis domestica (Gray short-tailed opossum) TR35979_c0_g1_i5 Q8K409 DPOLB_MOUSE 3.00E-152 GO:0006260; GO:0003887; GO:0006287; GO:0005737; GO:0003684; GO:0008630; GO:0016829; GO:0046872; GO:0008017; GO:0051402; GO:0006290; GO:0045471; GO:0005876; GO:0000795 "DNA replication; DNA-directed DNA polymerase activity; base-excision repair, gap-filling; cytoplasm; damaged DNA binding; intrinsic apoptotic signaling pathway in response to DNA damage; lyase activity; metal ion binding; microtubule binding; neuron apoptotic process; pyrimidine dimer repair; response to ethanol; spindle microtubule; synaptonemal complex" IPR002054; IPR019843; IPR010996; IPR028207; IPR018944; IPR022312; IPR002008; IPR003583; IPR027420; DNA polymerase beta (EC 2.7.7.7) (EC 4.2.99.-) Polb Mus musculus (Mouse) TR35979_c0_g1_i8 Q4R380 DPOLL_MACFA 1.00E-46 GO:0003677; GO:0006281; GO:0006260; GO:0003887; GO:0016829; GO:0046872; GO:0005634 DNA binding; DNA repair; DNA replication; DNA-directed DNA polymerase activity; lyase activity; metal ion binding; nucleus IPR001357; IPR002054; IPR019843; IPR010996; IPR028207; IPR018944; IPR022312; IPR002008; IPR027421; IPR003583; DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) POLL QtsA-18827 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR35980_c2_g1_i3 Q16611 BAK_HUMAN 8.00E-35 GO:0001783; GO:0001782; GO:0002352; GO:0097202; GO:0008635; GO:0007568; GO:0001974; GO:0007420; GO:0008283; GO:0034644; GO:0071260; GO:0005829; GO:0031018; GO:0005783; GO:0010248; GO:0031307; GO:0097193; GO:0070059; GO:0035108; GO:0046872; GO:0008053; GO:0002262; GO:0008285; GO:0010629; GO:0033137; GO:0031100; GO:0046930; GO:0043065; GO:0010524; GO:1900103; GO:1901030; GO:0045862; GO:0090200; GO:0048597; GO:0032471; GO:0051726; GO:0046902; GO:0051881; GO:0043497; GO:0043496; GO:0001836; GO:0010225; GO:0042493; GO:0045471; GO:0009620; GO:0010332; GO:0042542; GO:0010046; GO:0014070; GO:0060068 Itself; Q07812; Q07817; Q07817-1; Q07820; P97287; P24356 B cell apoptotic process; B cell homeostasis; B cell negative selection; activation of cysteine-type endopeptidase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; aging; blood vessel remodeling; brain development; cell proliferation; cellular response to UV; cellular response to mechanical stimulus; cytosol; endocrine pancreas development; endoplasmic reticulum; establishment or maintenance of transmembrane electrochemical gradient; integral to mitochondrial outer membrane; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; limb morphogenesis; metal ion binding; mitochondrial fusion; myeloid cell homeostasis; negative regulation of cell proliferation; negative regulation of gene expression; negative regulation of peptidyl-serine phosphorylation; organ regeneration; pore complex; positive regulation of apoptotic process; positive regulation of calcium ion transport into cytosol; positive regulation of endoplasmic reticulum unfolded protein response; positive regulation of mitochondrial outer membrane permeabilization; positive regulation of proteolysis; positive regulation of release of cytochrome c from mitochondria; post-embryonic camera-type eye morphogenesis; reduction of endoplasmic reticulum calcium ion concentration; regulation of cell cycle; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; regulation of protein heterodimerization activity; regulation of protein homodimerization activity; release of cytochrome c from mitochondria; response to UV-C; response to drug; response to ethanol; response to fungus; response to gamma radiation; response to hydrogen peroxide; response to mycotoxin; response to organic cyclic compound; vagina development IPR026308; IPR002475; IPR020717; IPR020726; IPR020728; IPR026298; Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7) BAK1 BAK BCL2L7 CDN1 Homo sapiens (Human) TR35981_c0_g1_i2 Q5DC69 CH10_SCHJA 2.00E-39 GO:0005524; GO:0005759; GO:0006457 ATP binding; mitochondrial matrix; protein folding IPR020818; IPR018369; IPR011032; "10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10)" SJCHGC01960 SJCHGC09469 Schistosoma japonicum (Blood fluke) TR35981_c0_g1_i4 Q5DC69 CH10_SCHJA 9.00E-39 GO:0005524; GO:0005759; GO:0006457 ATP binding; mitochondrial matrix; protein folding IPR020818; IPR018369; IPR011032; "10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10)" SJCHGC01960 SJCHGC09469 Schistosoma japonicum (Blood fluke) TR35986_c2_g2_i1 Q8CCP0 NEMF_MOUSE 0 GO:0005737; GO:0051168; GO:0005634 cytoplasm; nuclear export; nucleus IPR021846; IPR008532; IPR008616; Nuclear export mediator factor Nemf (Serologically defined colon cancer antigen 1 homolog) Nemf Sdccag1 Mus musculus (Mouse) TR35990_c0_g1_i1 Q3KQ77 EFCB1_XENLA 3.00E-56 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; EF-hand calcium-binding domain-containing protein 1 efcab1 Xenopus laevis (African clawed frog) TR35991_c0_g1_i1 Q9DBM0 ABCG8_MOUSE 5.00E-64 GO:0005524; GO:0016887; GO:0016324; GO:0033344; GO:0042632; GO:0017127; GO:0007588; GO:0016021; GO:0030299; GO:0045796; GO:0010949; GO:0015914 ATP binding; ATPase activity; apical plasma membrane; cholesterol efflux; cholesterol homeostasis; cholesterol transporter activity; excretion; integral to membrane; intestinal cholesterol absorption; negative regulation of intestinal cholesterol absorption; negative regulation of intestinal phytosterol absorption; phospholipid transport IPR013525; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family G member 8 (Sterolin-2) Abcg8 Mus musculus (Mouse) TR35991_c0_g1_i2 Q99PE7 ABCG5_RAT 1.00E-71 GO:0005524; GO:0043190; GO:0016887; GO:0016324; GO:0033344; GO:0042632; GO:0017127; GO:0007588; GO:0016021; GO:0045796; GO:0010949; GO:0030300; GO:0042493; GO:0010212; GO:0007584 ATP binding; ATP-binding cassette (ABC) transporter complex; ATPase activity; apical plasma membrane; cholesterol efflux; cholesterol homeostasis; cholesterol transporter activity; excretion; integral to membrane; negative regulation of intestinal cholesterol absorption; negative regulation of intestinal phytosterol absorption; regulation of intestinal cholesterol absorption; response to drug; response to ionizing radiation; response to nutrient IPR003593; IPR013525; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family G member 5 (Sterolin-1) Abcg5 Rattus norvegicus (Rat) TR35991_c0_g1_i3 Q8T5Z7 ABCA1_DICDI 3.00E-11 GO:0005524; GO:0042626; GO:0016021 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; integral to membrane" IPR003593; IPR026082; IPR003439; IPR027417; ABC transporter A family member 1 (ABC transporter ABCA.1) abcA1 abcA DDB_G0291994 Dictyostelium discoideum (Slime mold) TR35992_c12_g1_i1 Q5F418 PSMD1_CHICK 0 GO:0030234; GO:0022624; GO:0050790; GO:0042176 enzyme regulator activity; proteasome accessory complex; regulation of catalytic activity; regulation of protein catabolic process IPR016642; IPR011989; IPR016024; IPR002015; 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) PSMD1 RCJMB04_3m24 Gallus gallus (Chicken) TR35992_c12_g1_i2 Q5F418 PSMD1_CHICK 0 GO:0030234; GO:0022624; GO:0050790; GO:0042176 enzyme regulator activity; proteasome accessory complex; regulation of catalytic activity; regulation of protein catabolic process IPR016642; IPR011989; IPR016024; IPR002015; 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) PSMD1 RCJMB04_3m24 Gallus gallus (Chicken) TR35993_c1_g1_i3 Q642H2 CRBL2_DANRE 1.00E-21 GO:0030154; GO:0005634; GO:0045600; GO:0046326; GO:0046889; GO:0045893; GO:0043565; GO:0003700; GO:0006351 "cell differentiation; nucleus; positive regulation of fat cell differentiation; positive regulation of glucose import; positive regulation of lipid biosynthetic process; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; cAMP-responsive element-binding protein-like 2 crebl2 zgc:92620 Danio rerio (Zebrafish) (Brachydanio rerio) TR35994_c0_g1_i1 P00940 TPIS_CHICK 3.00E-40 GO:0005829; GO:0006094; GO:0019682; GO:0006096; GO:0006098; GO:0044281; GO:0004807 cytosol; gluconeogenesis; glyceraldehyde-3-phosphate metabolic process; glycolysis; pentose-phosphate shunt; small molecule metabolic process; triose-phosphate isomerase activity IPR013785; IPR022896; IPR000652; IPR020861; Carbohydrate biosynthesis; gluconeogenesis. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Triose-phosphate isomerase) TPI1 Gallus gallus (Chicken) TR35994_c4_g3_i1 P48494 TPIS_ORYSJ 2.00E-30 GO:0005737; GO:0006094; GO:0006096; GO:0006098; GO:0004807 cytoplasm; gluconeogenesis; glycolysis; pentose-phosphate shunt; triose-phosphate isomerase activity IPR013785; IPR022896; IPR000652; IPR020861; Carbohydrate biosynthesis; gluconeogenesis. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. "Triosephosphate isomerase, cytosolic (TIM) (Triose-phosphate isomerase) (EC 5.3.1.1)" TPI Os01g0147900 LOC_Os01g05490 P0416D03.45 P0434B04.9 Oryza sativa subsp. japonica (Rice) TR35995_c5_g1_i1 Q6GNM0 NRM_XENLA 2.00E-20 GO:0016021; GO:0005635; GO:0005637 integral to membrane; nuclear envelope; nuclear inner membrane Nurim (Nuclear envelope membrane protein) (Nuclear rim protein) nrm Xenopus laevis (African clawed frog) TR35997_c0_g1_i1 P86859 MYT3_MYTCA 6.00E-44 GO:0005576 extracellular region Mytilin-3 (Mytilus uncharacterized protein 3) (MUSP-3) Mytilus californianus (California mussel) TR35998_c6_g1_i2 Q5ZML6 F210A_CHICK 1.00E-39 GO:0016021; GO:0005739 integral to membrane; mitochondrion IPR009688; Protein FAM210A FAM210A RCJMB04_1k21 Gallus gallus (Chicken) TR35999_c1_g1_i1 Q9CPW7 ZMAT2_MOUSE 2.00E-47 GO:0003677; GO:0005634; GO:0008270 DNA binding; nucleus; zinc ion binding IPR015880; IPR022755; IPR003604; Zinc finger matrin-type protein 2 Zmat2 Mus musculus (Mouse) TR35999_c1_g1_i5 Q9CPW7 ZMAT2_MOUSE 2.00E-46 GO:0003677; GO:0005634; GO:0008270 DNA binding; nucleus; zinc ion binding IPR015880; IPR022755; IPR003604; Zinc finger matrin-type protein 2 Zmat2 Mus musculus (Mouse) TR36_c0_g1_i1 P39057 DYHC_ANTCR 1.00E-31 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein beta chain, ciliary" Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR36001_c1_g1_i2 Q9V579 PREL_DROME 1.00E-34 GO:0048813; GO:0030061; GO:0070584 dendrite morphogenesis; mitochondrial crista; mitochondrion morphogenesis IPR006797; Protein preli-like prel CG8806 Drosophila melanogaster (Fruit fly) TR36001_c1_g1_i3 Q90673 PRLD1_CHICK 6.00E-35 GO:0005739 mitochondrion IPR006797; "PRELI domain-containing protein 1, mitochondrial (Px19-like protein)" PRELID1 Gallus gallus (Chicken) TR36002_c0_g1_i1 Q9Y2R5 RT17_HUMAN 2.00E-06 GO:0005763; GO:0019843; GO:0003735; GO:0006412 mitochondrial small ribosomal subunit; rRNA binding; structural constituent of ribosome; translation IPR012340; IPR000266; "28S ribosomal protein S17, mitochondrial (MRP-S17) (S17mt)" MRPS17 RPMS17 HSPC011 Homo sapiens (Human) TR36002_c1_g1_i1 Q8WYN3 CSRN3_HUMAN 1.00E-31 GO:0003677; GO:0006915; GO:0010923; GO:0005634; GO:0043065; GO:0045944; GO:0003700; GO:0006351 "DNA binding; apoptotic process; negative regulation of phosphatase activity; nucleus; positive regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR023260; Cysteine/serine-rich nuclear protein 3 (CSRNP-3) (Protein FAM130A2) (TGF-beta-induced apoptosis protein 2) (TAIP-2) CSRNP3 FAM130A2 TAIP2 Homo sapiens (Human) TR36003_c0_g1_i2 O75351 VPS4B_HUMAN 4.00E-126 GO:0005524; GO:0042623; GO:0007049; GO:0051301; GO:0005829; GO:0005769; GO:0010008; GO:0007032; GO:0032510; GO:0032367; GO:0005770; GO:0031902; GO:0005764; GO:0005634; GO:0006813; GO:0015031; GO:0033993; GO:0005774; GO:0016032 "ATP binding; ATPase activity, coupled; cell cycle; cell division; cytosol; early endosome; endosome membrane; endosome organization; endosome to lysosome transport via multivesicular body sorting pathway; intracellular cholesterol transport; late endosome; late endosome membrane; lysosome; nucleus; potassium ion transport; protein transport; response to lipid; vacuolar membrane; viral process" IPR003593; IPR003959; IPR003960; IPR007330; IPR027417; IPR015415; Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1) VPS4B SKD1 VPS42 MIG1 Homo sapiens (Human) TR36003_c0_g1_i3 O75351 VPS4B_HUMAN 6.00E-80 GO:0005524; GO:0042623; GO:0007049; GO:0051301; GO:0005829; GO:0005769; GO:0010008; GO:0007032; GO:0032510; GO:0032367; GO:0005770; GO:0031902; GO:0005764; GO:0005634; GO:0006813; GO:0015031; GO:0033993; GO:0005774; GO:0016032 "ATP binding; ATPase activity, coupled; cell cycle; cell division; cytosol; early endosome; endosome membrane; endosome organization; endosome to lysosome transport via multivesicular body sorting pathway; intracellular cholesterol transport; late endosome; late endosome membrane; lysosome; nucleus; potassium ion transport; protein transport; response to lipid; vacuolar membrane; viral process" IPR003593; IPR003959; IPR003960; IPR007330; IPR027417; IPR015415; Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1) VPS4B SKD1 VPS42 MIG1 Homo sapiens (Human) TR36003_c0_g1_i4 Q3B8D5 KATL2_XENLA 6.00E-24 GO:0005524; GO:0005737; GO:0005874; GO:0051013; GO:0008568 ATP binding; cytoplasm; microtubule; microtubule severing; microtubule-severing ATPase activity IPR003593; IPR003959; IPR027497; IPR006594; IPR013720; IPR027417; Katanin p60 ATPase-containing subunit A-like 2 (Katanin p60 subunit A-like 2) (EC 3.6.4.3) (p60 katanin-like 2) katnal2 Xenopus laevis (African clawed frog) TR36004_c0_g2_i1 P45359 THLA_CLOAB 1.00E-109 GO:0003985; GO:0005737 acetyl-CoA C-acetyltransferase activity; cytoplasm IPR002155; IPR016039; IPR016038; IPR020615; IPR020610; IPR020617; IPR020613; IPR020616; Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3. Acetyl-CoA acetyltransferase (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) thlA thl CA_C2873 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) TR36004_c0_g2_i3 Q3T0R7 THIM_BOVIN 2.00E-176 GO:0003988; GO:0006631; GO:0005743; GO:0005739; GO:1901029 acetyl-CoA C-acyltransferase activity; fatty acid metabolic process; mitochondrial inner membrane; mitochondrion; negative regulation of mitochondrial outer membrane permeabilization IPR002155; IPR016039; IPR016038; IPR020615; IPR020610; IPR020617; IPR020613; IPR020616; Lipid metabolism; fatty acid metabolism. "3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase)" ACAA2 Bos taurus (Bovine) TR36005_c0_g1_i1 Q3UDE2 TTL12_MOUSE 0 GO:0006464 cellular protein modification process IPR004344; IPR027749; Tubulin--tyrosine ligase-like protein 12 Ttll12 Mus musculus (Mouse) TR36006_c1_g1_i3 P81546 TIMP1_CANFA 1.00E-06 GO:0043249; GO:0005576; GO:0046872; GO:0008191 erythrocyte maturation; extracellular region; metal ion binding; metalloendopeptidase inhibitor activity IPR001134; IPR001820; IPR008993; IPR015611; IPR027465; Metalloproteinase inhibitor 1 (Tissue inhibitor of metalloproteinases 1) (TIMP-1) TIMP1 Canis familiaris (Dog) (Canis lupus familiaris) TR36006_c1_g9_i2 P81546 TIMP1_CANFA 3.00E-10 GO:0043249; GO:0005576; GO:0046872; GO:0008191 erythrocyte maturation; extracellular region; metal ion binding; metalloendopeptidase inhibitor activity IPR001134; IPR001820; IPR008993; IPR015611; IPR027465; Metalloproteinase inhibitor 1 (Tissue inhibitor of metalloproteinases 1) (TIMP-1) TIMP1 Canis familiaris (Dog) (Canis lupus familiaris) TR36006_c1_g9_i3 P39876 TIMP3_MOUSE 4.00E-10 GO:0005604; GO:0071310; GO:0046872; GO:0008191; GO:0051045 basement membrane; cellular response to organic substance; metal ion binding; metalloendopeptidase inhibitor activity; negative regulation of membrane protein ectodomain proteolysis IPR001134; IPR001820; IPR008993; IPR027465; IPR015612; Metalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) (TIMP-3) Timp3 Sun Timp-3 Mus musculus (Mouse) TR36009_c0_g1_i1 Q8BZI6 CV013_MOUSE 4.00E-55 IPR018616; Protein GUCD1 (Guanylyl cyclase domain-containing protein 1) (Protein LLN4) Gucd1 Mus musculus (Mouse) TR36011_c1_g1_i3 Q6AXP1 CS044_RAT 1.00E-32 IPR027884; Uncharacterized protein C19orf44 homolog Rattus norvegicus (Rat) TR36011_c1_g1_i4 Q9H6X5 CS044_HUMAN 3.00E-32 IPR027884; Uncharacterized protein C19orf44 C19orf44 Homo sapiens (Human) TR36011_c1_g1_i6 Q9H6X5 CS044_HUMAN 3.00E-32 IPR027884; Uncharacterized protein C19orf44 C19orf44 Homo sapiens (Human) TR36011_c1_g1_i7 Q6AXP1 CS044_RAT 1.00E-32 IPR027884; Uncharacterized protein C19orf44 homolog Rattus norvegicus (Rat) TR36012_c0_g1_i1 Q86WG5 MTMRD_HUMAN 3.00E-12 GO:0017112; GO:0016020; GO:0042552; GO:0016791; GO:0019208; GO:0035091; GO:0051262; GO:0005774 Rab guanyl-nucleotide exchange factor activity; membrane; myelination; phosphatase activity; phosphatase regulator activity; phosphatidylinositol binding; protein tetramerization; vacuolar membrane IPR005112; IPR001194; IPR004182; IPR010569; IPR017906; IPR011993; IPR001849; IPR022096; IPR005113; Myotubularin-related protein 13 (SET-binding factor 2) SBF2 CMT4B2 KIAA1766 MTMR13 Homo sapiens (Human) TR36012_c2_g3_i1 Q6IQ26 DEN5A_HUMAN 0 GO:0005794; GO:0017112; GO:0016020 Golgi apparatus; Rab guanyl-nucleotide exchange factor activity; membrane IPR005112; IPR001194; IPR008976; IPR001024; IPR004012; IPR005113; DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) DENND5A KIAA1091 RAB6IP1 Homo sapiens (Human) TR36012_c2_g3_i2 C8YR32 LOXH1_MOUSE 3.00E-10 GO:0005262; GO:0050982; GO:0016020; GO:0007605; GO:0032420 calcium channel activity; detection of mechanical stimulus; membrane; sensory perception of sound; stereocilium IPR008976; IPR001024; Lipoxygenase homology domain-containing protein 1 Loxhd1 Mus musculus (Mouse) TR36012_c2_g3_i3 Q6IQ26 DEN5A_HUMAN 0 GO:0005794; GO:0017112; GO:0016020 Golgi apparatus; Rab guanyl-nucleotide exchange factor activity; membrane IPR005112; IPR001194; IPR008976; IPR001024; IPR004012; IPR005113; DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) DENND5A KIAA1091 RAB6IP1 Homo sapiens (Human) TR36012_c2_g3_i4 C8YR32 LOXH1_MOUSE 3.00E-10 GO:0005262; GO:0050982; GO:0016020; GO:0007605; GO:0032420 calcium channel activity; detection of mechanical stimulus; membrane; sensory perception of sound; stereocilium IPR008976; IPR001024; Lipoxygenase homology domain-containing protein 1 Loxhd1 Mus musculus (Mouse) TR36013_c0_g1_i1 Q8R173 ZDHC3_MOUSE 2.00E-95 GO:0005794; GO:0000139; GO:0016021; GO:0016409; GO:0018345; GO:0006605; GO:0008270 Golgi apparatus; Golgi membrane; integral to membrane; palmitoyltransferase activity; protein palmitoylation; protein targeting; zinc ion binding IPR001594; Palmitoyltransferase ZDHHC3 (EC 2.3.1.225) (GABA-A receptor-associated membrane protein 1) (Golgi-specific DHHC zinc finger protein) (Zinc finger DHHC domain-containing protein 3) (DHHC-3) Zdhhc3 Godz Gramp1 Mus musculus (Mouse) TR36014_c0_g1_i1 P42575 CASP2_HUMAN 2.00E-17 GO:0006977; GO:0007568; GO:0097190; GO:0007420; GO:0071260; GO:0004197; GO:0005829; GO:0019899; GO:0097194; GO:0001554; GO:0016020; GO:0005739; GO:0003407; GO:0048011; GO:0005634; GO:0043065; GO:0043525; GO:0016485; GO:0006508; GO:0043281 P42575-1; P78560; P78527 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; aging; apoptotic signaling pathway; brain development; cellular response to mechanical stimulus; cysteine-type endopeptidase activity; cytosol; enzyme binding; execution phase of apoptosis; luteolysis; membrane; mitochondrion; neural retina development; neurotrophin TRK receptor signaling pathway; nucleus; positive regulation of apoptotic process; positive regulation of neuron apoptotic process; protein processing; proteolysis; regulation of cysteine-type endopeptidase activity involved in apoptotic process" IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 NEDD2 Homo sapiens (Human) TR36014_c0_g1_i4 Q5IS99 CASP3_SAIBB 3.00E-22 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Saimiri boliviensis boliviensis (Bolivian squirrel monkey) TR36016_c1_g1_i1 Q92504 S39A7_HUMAN 6.00E-73 GO:0005794; GO:0005789; GO:0016021; GO:0046873; GO:0055085; GO:0006829 P68400 Golgi apparatus; endoplasmic reticulum membrane; integral to membrane; metal ion transmembrane transporter activity; transmembrane transport; zinc ion transport IPR003689; "Zinc transporter SLC39A7 (Histidine-rich membrane protein Ke4) (Really interesting new gene 5 protein) (Solute carrier family 39 member 7) (Zrt-, Irt-like protein 7) (ZIP7)" SLC39A7 HKE4 RING5 Homo sapiens (Human) TR36016_c1_g1_i2 Q92504 S39A7_HUMAN 5.00E-73 GO:0005794; GO:0005789; GO:0016021; GO:0046873; GO:0055085; GO:0006829 P68400 Golgi apparatus; endoplasmic reticulum membrane; integral to membrane; metal ion transmembrane transporter activity; transmembrane transport; zinc ion transport IPR003689; "Zinc transporter SLC39A7 (Histidine-rich membrane protein Ke4) (Really interesting new gene 5 protein) (Solute carrier family 39 member 7) (Zrt-, Irt-like protein 7) (ZIP7)" SLC39A7 HKE4 RING5 Homo sapiens (Human) TR36017_c0_g1_i1 Q2TBL4 RPC3_BOVIN 5.00E-160 GO:0003677; GO:0003899; GO:0051607; GO:0045087; GO:0005634; GO:0045089; GO:0032728; GO:0006351 "DNA binding; DNA-directed RNA polymerase activity; defense response to virus; innate immune response; nucleus; positive regulation of innate immune response; positive regulation of interferon-beta production; transcription, DNA-dependent" IPR013197; IPR008806; DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (DNA-directed RNA polymerase III subunit C) POLR3C Bos taurus (Bovine) TR36020_c1_g2_i1 Q2KIN5 HEM3_BOVIN 1.00E-118 GO:0004418; GO:0018160; GO:0006782 hydroxymethylbilane synthase activity; peptidyl-pyrromethane cofactor linkage; protoporphyrinogen IX biosynthetic process IPR000860; IPR022419; IPR022417; IPR022418; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. Porphobilinogen deaminase (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) HMBS Bos taurus (Bovine) TR36021_c0_g1_i1 O12990 JAK1_DANRE 5.00E-20 GO:0005524; GO:0005856; GO:0012505; GO:0007243; GO:0016020; GO:0007275; GO:0004715; GO:0018108 ATP binding; cytoskeleton; endomembrane system; intracellular protein kinase cascade; membrane; multicellular organismal development; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR019749; IPR019748; IPR000299; IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR008266; IPR020635; IPR016251; IPR020776; Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) jak1 Danio rerio (Zebrafish) (Brachydanio rerio) TR36021_c4_g1_i3 O54967 ACK1_MOUSE 2.00E-51 GO:0005524; GO:0005912; GO:0030424; GO:0030136; GO:0005905; GO:0030659; GO:0030425; GO:0006897; GO:0005768; GO:0030426; GO:0046872; GO:0043025; GO:0004715; GO:0005634; GO:0018108; GO:0005886; GO:0004674 ATP binding; adherens junction; axon; clathrin-coated vesicle; coated pit; cytoplasmic vesicle membrane; dendrite; endocytosis; endosome; growth cone; metal ion binding; neuronal cell body; non-membrane spanning protein tyrosine kinase activity; nucleus; peptidyl-tyrosine phosphorylation; plasma membrane; protein serine/threonine kinase activity IPR015116; IPR021619; IPR011009; IPR000719; IPR017441; IPR001245; IPR001452; IPR008266; IPR020635; IPR009060; IPR000449; Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2) Tnk2 Ack1 Mus musculus (Mouse) TR36021_c5_g1_i1 O13148 EPA4A_DANRE 6.00E-50 GO:0005524; GO:0005769; GO:0018108; GO:0005886; GO:0004714 ATP binding; early endosome; peptidyl-tyrosine phosphorylation; plasma membrane; transmembrane receptor protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Ephrin type-A receptor 4a (EC 2.7.10.1) (EPH-like kinase 2) (Tyrosine-protein kinase receptor ZEK2) (Fragment) epha4a ek2 zek2 Danio rerio (Zebrafish) (Brachydanio rerio) TR36021_c5_g1_i2 P43404 ZAP70_MOUSE 3.00E-50 GO:0005524; GO:0042101; GO:0050852; GO:0043366; GO:0005829; GO:0006955; GO:0001772; GO:0035556; GO:0045060; GO:0004715; GO:0046638; GO:0046641; GO:0050850; GO:0045059; GO:0046777; GO:0004713 ATP binding; T cell receptor complex; T cell receptor signaling pathway; beta selection; cytosol; immune response; immunological synapse; intracellular signal transduction; negative thymic T cell selection; non-membrane spanning protein tyrosine kinase activity; positive regulation of alpha-beta T cell differentiation; positive regulation of alpha-beta T cell proliferation; positive regulation of calcium-mediated signaling; positive thymic T cell selection; protein autophosphorylation; protein tyrosine kinase activity IPR011009; IPR023420; IPR000719; IPR017441; IPR001245; IPR000980; IPR008266; IPR020635; IPR012234; Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) Zap70 Srk Zap-70 Mus musculus (Mouse) TR36021_c5_g1_i3 P79701 VGFR3_COTCO 3.00E-30 GO:0005524; GO:0001525; GO:0030154; GO:0005887; GO:0018108; GO:0048010; GO:0038084; GO:0005021 ATP binding; angiogenesis; cell differentiation; integral to plasma membrane; peptidyl-tyrosine phosphorylation; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor signaling pathway; vascular endothelial growth factor-activated receptor activity IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR001824; IPR009137; Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Endothelial kinase receptor EK2) (Quek 2) (Quek2) FLT4 K2 VEGFR3 Coturnix coturnix (Common quail) (Tetrao coturnix) TR36021_c5_g1_i4 P52583 VGFR2_COTJA 4.00E-31 GO:0005524; GO:0001525; GO:0030154; GO:0030054; GO:0016023; GO:0005769; GO:0016021; GO:0018108; GO:0005886; GO:0001934; GO:0046777; GO:0048010; GO:0038084; GO:0005021 ATP binding; angiogenesis; cell differentiation; cell junction; cytoplasmic membrane-bounded vesicle; early endosome; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; positive regulation of protein phosphorylation; protein autophosphorylation; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor signaling pathway; vascular endothelial growth factor-activated receptor activity IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR001824; IPR009136; Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Endothelial kinase receptor EK1) (Quek 1) (Quek1) KDR EK1 FLK-1 Coturnix coturnix japonica (Japanese quail) (Coturnix japonica) TR36022_c1_g1_i1 Q0WYX8 MDGA1_CHICK 5.00E-19 GO:0046658; GO:0001764 anchored to plasma membrane; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 MDGA1 Gallus gallus (Chicken) TR36022_c1_g2_i2 P60755 MDGA2_MOUSE 5.00E-14 GO:0031225; GO:0007389; GO:0005886 anchored to membrane; pattern specification process; plasma membrane IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 2 (MAM domain-containing protein 1) Mdga2 Mamdc1 Mus musculus (Mouse) TR36022_c1_g2_i3 Q8NFP4 MDGA1_HUMAN 6.00E-19 GO:0046658; GO:0007420; GO:0001764; GO:0021527 anchored to plasma membrane; brain development; neuron migration; spinal cord association neuron differentiation IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3) MDGA1 MAMDC3 Homo sapiens (Human) TR36022_c1_g2_i4 Q7Z304 MAMC2_HUMAN 2.00E-17 GO:0005783; GO:0005539; GO:0005614; GO:0016020; GO:0019800 endoplasmic reticulum; glycosaminoglycan binding; interstitial matrix; membrane; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IPR008985; IPR000998; MAM domain-containing protein 2 (MAM domain-containing proteoglycan) (Mamcan) MAMDC2 Homo sapiens (Human) TR36023_c6_g1_i1 B0BN95 HARB1_RAT 5.00E-27 GO:0005813; GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 centrosome; cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) Harbi1 Rattus norvegicus (Rat) TR36024_c0_g1_i1 Q91062 VIT_ICHUN 4.00E-10 GO:0005319; GO:0045735 lipid transporter activity; nutrient reservoir activity IPR015819; IPR001747; IPR015816; IPR015258; IPR015255; IPR015817; IPR015818; IPR011030; IPR001846; Vitellogenin (VTG) [Cleaved into: Lipovitellin LV-1N; Lipovitellin LV-1C; Lipovitellin LV-2] Ichthyomyzon unicuspus (Silver lamprey) TR36024_c0_g2_i1 P18947 VIT4_CAEEL 5.00E-09 GO:0005576; GO:0005319; GO:0045735 extracellular region; lipid transporter activity; nutrient reservoir activity IPR015819; IPR001747; IPR015816; IPR015255; IPR015817; IPR015818; IPR011030; IPR001846; Vitellogenin-4 vit-4 F59D8.2 Caenorhabditis elegans TR36024_c2_g2_i1 P18948 VIT6_CAEEL 3.00E-15 GO:0005576; GO:0005319; GO:0045735 extracellular region; lipid transporter activity; nutrient reservoir activity IPR015819; IPR001747; IPR015816; IPR015255; IPR015817; IPR015818; IPR011030; IPR001846; Vitellogenin-6 vit-6 K07H8.6 Caenorhabditis elegans TR36025_c2_g1_i1 P35251 RFC1_HUMAN 0 GO:0005524; GO:0003689; GO:0005663; GO:0006271; GO:0008047; GO:0000278; GO:0005654; GO:0006297; GO:0006355; GO:0000722; GO:0032201; GO:0007004; GO:0006351; GO:0006283 P35250 "ATP binding; DNA clamp loader activity; DNA replication factor C complex; DNA strand elongation involved in DNA replication; enzyme activator activity; mitotic cell cycle; nucleoplasm; nucleotide-excision repair, DNA gap filling; regulation of transcription, DNA-dependent; telomere maintenance via recombination; telomere maintenance via semi-conservative replication; telomere maintenance via telomerase; transcription, DNA-dependent; transcription-coupled nucleotide-excision repair" IPR003593; IPR003959; IPR001357; IPR008921; IPR012178; IPR013725; IPR027417; Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) RFC1 RFC140 Homo sapiens (Human) TR36025_c2_g2_i2 Q3MGE7 DNLJ_ANAVT 4.00E-17 GO:0003677; GO:0003911; GO:0006281; GO:0006260; GO:0046872 DNA binding; DNA ligase (NAD+) activity; DNA repair; DNA replication; metal ion binding IPR001357; IPR018239; IPR004150; IPR001679; IPR013839; IPR013840; IPR003583; IPR012340; IPR010994; IPR004149; DNA ligase (EC 6.5.1.2) (Polydeoxyribonucleotide synthase [NAD(+)]) ligA Ava_0313 Anabaena variabilis (strain ATCC 29413 / PCC 7937) TR36027_c0_g1_i2 Q63340 DUS7_RAT 2.00E-52 GO:0017017; GO:0005829; GO:0004725 MAP kinase tyrosine/serine/threonine phosphatase activity; cytosol; protein tyrosine phosphatase activity IPR000340; IPR020422; IPR024950; IPR008343; IPR001763; IPR000387; Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase MKP-X) (Fragment) Dusp7 Mkpx Rattus norvegicus (Rat) TR36028_c1_g2_i1 Q9Y2L5 TPPC8_HUMAN 1.00E-131 GO:0006888; GO:0005794; GO:0005801 ER to Golgi vesicle-mediated transport; Golgi apparatus; cis-Golgi network IPR011990; IPR024420; Trafficking protein particle complex subunit 8 (Protein TRS85 homolog) TRAPPC8 KIAA1012 Homo sapiens (Human) TR36029_c0_g1_i3 Q9Y6N5 SQRD_HUMAN 3.00E-170 GO:0034641; GO:0005743; GO:0070221; GO:0070224; GO:0000098 "cellular nitrogen compound metabolic process; mitochondrial inner membrane; sulfide oxidation, using sulfide:quinone oxidoreductase; sulfide:quinone oxidoreductase activity; sulfur amino acid catabolic process" IPR023753; IPR015904; "Sulfide:quinone oxidoreductase, mitochondrial (EC 1.-.-.-)" SQRDL CGI-44 Homo sapiens (Human) TR36029_c0_g1_i5 Q9Y6N5 SQRD_HUMAN 9.00E-171 GO:0034641; GO:0005743; GO:0070221; GO:0070224; GO:0000098 "cellular nitrogen compound metabolic process; mitochondrial inner membrane; sulfide oxidation, using sulfide:quinone oxidoreductase; sulfide:quinone oxidoreductase activity; sulfur amino acid catabolic process" IPR023753; IPR015904; "Sulfide:quinone oxidoreductase, mitochondrial (EC 1.-.-.-)" SQRDL CGI-44 Homo sapiens (Human) TR36030_c0_g1_i1 C3YFB4 DRE2_BRAFL 9.00E-85 GO:0051537; GO:0006915; GO:0009055; GO:0016226; GO:0046872; GO:0005758; GO:0043066 "2 iron, 2 sulfur cluster binding; apoptotic process; electron carrier activity; iron-sulfur cluster assembly; metal ion binding; mitochondrial intermembrane space; negative regulation of apoptotic process" IPR007785; Anamorsin homolog (Fe-S cluster assembly protein DRE2 homolog) BRAFLDRAFT_58504 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR36030_c0_g1_i3 Q5EAC7 CPIN1_BOVIN 2.00E-66 GO:0051537; GO:0006915; GO:0009055; GO:0030097; GO:0016226; GO:0046872; GO:0005758; GO:0043066; GO:0005730 "2 iron, 2 sulfur cluster binding; apoptotic process; electron carrier activity; hemopoiesis; iron-sulfur cluster assembly; metal ion binding; mitochondrial intermembrane space; negative regulation of apoptotic process; nucleolus" IPR007785; Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) CIAPIN1 Bos taurus (Bovine) TR36032_c0_g1_i1 Q56A24 KLH24_RAT 5.00E-52 GO:0030424; GO:0005737; GO:0043204 axon; cytoplasm; perikaryon IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) Klhl24 Dre1 Rattus norvegicus (Rat) TR36032_c0_g1_i2 Q96CT2 KLH29_HUMAN 7.00E-40 IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 29 (Kelch repeat and BTB domain-containing protein 9) KLHL29 KBTBD9 KIAA1921 Homo sapiens (Human) TR36034_c0_g1_i2 Q6AI12 ANR40_HUMAN 8.00E-30 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 40 ANKRD40 Homo sapiens (Human) TR36034_c0_g1_i3 Q5SUE8 ANR40_MOUSE 5.00E-31 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 40 Ankrd40 Mus musculus (Mouse) TR36034_c0_g1_i8 Q5SUE8 ANR40_MOUSE 6.00E-31 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 40 Ankrd40 Mus musculus (Mouse) TR36036_c1_g1_i1 Q9CWD8 NUBPL_MOUSE 7.00E-112 GO:0051539; GO:0005524; GO:0046872; GO:0032981; GO:0005739; GO:0070584 "4 iron, 4 sulfur cluster binding; ATP binding; metal ion binding; mitochondrial respiratory chain complex I assembly; mitochondrion; mitochondrion morphogenesis" IPR025669; IPR019591; IPR000808; IPR027417; Iron-sulfur protein NUBPL (Nucleotide-binding protein-like) Nubpl Mus musculus (Mouse) TR36036_c1_g1_i2 Q6CMN0 NBP35_KLULA 7.00E-41 GO:0051539; GO:0005524; GO:0005737; GO:0046872; GO:0005634 "4 iron, 4 sulfur cluster binding; ATP binding; cytoplasm; metal ion binding; nucleus" IPR019591; IPR000808; IPR027417; Cytosolic Fe-S cluster assembly factor NBP35 (Nucleotide-binding protein 35) NBP35 KLLA0E19074g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR36036_c1_g1_i4 Q54F15 NUBPL_DICDI 8.00E-88 GO:0005524; GO:0051536; GO:0046872; GO:0005739 ATP binding; iron-sulfur cluster binding; metal ion binding; mitochondrion IPR019591; IPR015223; IPR027417; Iron-sulfur protein NUBPL (Nucleotide-binding protein-like) nubpl DDB_G0291193 Dictyostelium discoideum (Slime mold) TR36037_c2_g1_i1 P53668 LIMK1_MOUSE 6.00E-19 GO:0005524; GO:0005737; GO:0005925; GO:0051444; GO:0043005; GO:0005634; GO:0045773; GO:0051496; GO:0006468; GO:0004674; GO:0008270 ATP binding; cytoplasm; focal adhesion; negative regulation of ubiquitin-protein ligase activity; neuron projection; nucleus; positive regulation of axon extension; positive regulation of stress fiber assembly; protein phosphorylation; protein serine/threonine kinase activity; zinc ion binding IPR011009; IPR001478; IPR000719; IPR017441; IPR001245; IPR001781; LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1) (KIZ-1) Limk1 Limk Mus musculus (Mouse) TR36037_c2_g1_i2 P29294 MYLK_RABIT 2.00E-106 GO:0005524; GO:0032154; GO:0005737; GO:0005856; GO:0030027; GO:0046872; GO:0004687 ATP binding; cleavage furrow; cytoplasm; cytoskeleton; lamellipodium; metal ion binding; myosin light chain kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR020675; IPR000719; IPR017441; IPR002290; IPR008271; "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]" MYLK Oryctolagus cuniculus (Rabbit) TR36037_c2_g1_i3 Q86YV6 MYLK4_HUMAN 1.00E-98 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR020636; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Myosin light chain kinase family member 4 (EC 2.7.11.1) (Sugen kinase 85) (SgK085) MYLK4 SGK085 Homo sapiens (Human) TR36037_c2_g1_i4 O43930 PRKY_HUMAN 6.00E-26 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR002290; IPR008271; Putative serine/threonine-protein kinase PRKY (EC 2.7.11.1) PRKY Homo sapiens (Human) TR36037_c2_g1_i5 B1WAR9 GWL_XENTR 1.00E-08 GO:0005524; GO:0000086; GO:0051301; GO:0005813; GO:0032154; GO:0005737; GO:0007067; GO:0034048; GO:0005634; GO:0051721; GO:0004674; GO:0006974 ATP binding; G2/M transition of mitotic cell cycle; cell division; centrosome; cleavage furrow; cytoplasm; mitosis; negative regulation of protein phosphatase type 2A activity; nucleus; protein phosphatase 2A binding; protein serine/threonine kinase activity; response to DNA damage stimulus IPR000961; IPR011009; IPR000719; IPR008271; Serine/threonine-protein kinase greatwall (GW) (GWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) mastl gw gwl Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36040_c0_g1_i1 O05218 YWRD_BACSU 8.00E-87 GO:0003840; GO:0036374; GO:0006749 gamma-glutamyltransferase activity; glutathione hydrolase activity; glutathione metabolic process IPR000101; Putative gamma-glutamyltransferase YwrD (EC 2.3.2.2) (Glutathione hydrolase) (EC 3.4.19.13) [Cleaved into: Gamma-glutamyltranspeptidase large chain; Gamma-glutamyltranspeptidase small chain] ywrD BSU36100 Bacillus subtilis (strain 168) TR36041_c2_g1_i2 Q9P601 MOB1_NEUCR 2.00E-49 IPR005301; Probable maintenance of ploidy protein mob1 B2O8.160 NCU01605 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR36041_c2_g1_i3 Q7K0E3 MOB4_DROME 7.00E-06 GO:0008088; GO:0005829; GO:0046872; GO:0000226; GO:0045886; GO:0048812; GO:0043195 axon cargo transport; cytosol; metal ion binding; microtubule cytoskeleton organization; negative regulation of synaptic growth at neuromuscular junction; neuron projection morphogenesis; terminal bouton IPR005301; MOB kinase activator-like 4 (Mob as tumor suppressor protein 4) (Dmob4) (Mps one binder kinase activator-like 4) Mob4 CG3403 Drosophila melanogaster (Fruit fly) TR36041_c2_g1_i4 Q29RK9 MOB3B_BOVIN 8.00E-98 GO:0046872 metal ion binding IPR005301; MOB kinase activator 3B (Mob1 homolog 2b) (Mps one binder kinase activator-like 2B) MOB3B MOBKL2B Bos taurus (Bovine) TR36041_c2_g1_i5 Q3T1J9 MOB1A_RAT 8.00E-66 GO:0035329; GO:0046872 hippo signaling cascade; metal ion binding IPR005301; MOB kinase activator 1A (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B) Mob1a Mobk1b Mobkl1b Rattus norvegicus (Rat) TR36041_c2_g1_i6 Q29RK9 MOB3B_BOVIN 2.00E-96 GO:0046872 metal ion binding IPR005301; MOB kinase activator 3B (Mob1 homolog 2b) (Mps one binder kinase activator-like 2B) MOB3B MOBKL2B Bos taurus (Bovine) TR36041_c2_g1_i7 Q5EAA4 MOB3C_BOVIN 2.00E-96 GO:0046872 metal ion binding IPR005301; MOB kinase activator 3C (Mob1 homolog 2C) (Mps one binder kinase activator-like 2C) MOB3C MOBKL2C Bos taurus (Bovine) TR36042_c0_g2_i1 Q6R5N8 TLR13_MOUSE 4.00E-20 GO:0002755; GO:0005768; GO:0010008; GO:0006954; GO:0045087; GO:0016021; GO:0042803; GO:0019843; GO:0043408; GO:0002237; GO:0009615; GO:0034178; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; endosome; endosome membrane; inflammatory response; innate immune response; integral to membrane; protein homodimerization activity; rRNA binding; regulation of MAPK cascade; response to molecule of bacterial origin; response to virus; toll-like receptor 13 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR003591; IPR000157; IPR027196; Toll-like receptor 13 Tlr13 Mus musculus (Mouse) TR36042_c0_g2_i2 Q5I2M4 TLR9_SHEEP 3.00E-07 GO:0002755; GO:0032009; GO:0005783; GO:0005789; GO:0005768; GO:0006954; GO:0045087; GO:0016021; GO:0005764; GO:0050729; GO:0045356; GO:0045359; GO:0045078; GO:0050707; GO:0002237; GO:0035197; GO:0034162; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; early phagosome; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; inflammatory response; innate immune response; integral to membrane; lysosome; positive regulation of inflammatory response; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-gamma biosynthetic process; regulation of cytokine secretion; response to molecule of bacterial origin; siRNA binding; toll-like receptor 9 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR000157; IPR027181; Toll-like receptor 9 (CD antigen CD289) TLR9 Ovis aries (Sheep) TR36043_c0_g1_i1 Q9JHG0 CBLN3_MOUSE 2.00E-09 GO:0005794; GO:0030054; GO:0005783; GO:0005615; GO:0045202 Golgi apparatus; cell junction; endoplasmic reticulum; extracellular space; synapse IPR001073; IPR008983; Cerebellin-3 Cbln3 Mus musculus (Mouse) TR36047_c1_g1_i1 Q9ULI3 HEG1_HUMAN 1.00E-13 GO:0005509; GO:0003209; GO:0005911; GO:0045216; GO:0001886; GO:0009897; GO:0005576; GO:0001701; GO:0016021; GO:0030324; GO:0003017; GO:0001945; GO:0035264; GO:0060039; GO:0009791; GO:0050878; GO:0001570; GO:0048845; GO:0003281 calcium ion binding; cardiac atrium morphogenesis; cell-cell junction; cell-cell junction organization; endothelial cell morphogenesis; external side of plasma membrane; extracellular region; in utero embryonic development; integral to membrane; lung development; lymph circulation; lymph vessel development; multicellular organism growth; pericardium development; post-embryonic development; regulation of body fluid levels; vasculogenesis; venous blood vessel morphogenesis; ventricular septum development IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; Protein HEG homolog 1 HEG1 KIAA1237 Homo sapiens (Human) TR36047_c1_g1_i2 P07207 NOTCH_DROME 1.00E-22 GO:0005796; GO:0061382; GO:0007219; GO:0048052; GO:0007464; GO:0045466; GO:0045463; GO:0007460; GO:0007015; GO:0005912; GO:0008356; GO:0007298; GO:0005509; GO:0009986; GO:0008407; GO:0003682; GO:0042676; GO:0046667; GO:0005829; GO:0008340; GO:0046843; GO:0007391; GO:0007451; GO:0007398; GO:0035165; GO:0005788; GO:0005768; GO:0061331; GO:0035153; GO:0035214; GO:0007440; GO:0060288; GO:0030718; GO:0030708; GO:0007403; GO:0008347; GO:0035172; GO:0007157; GO:0007446; GO:0016348; GO:0048803; GO:0008587; GO:0007474; GO:0016021; GO:0035171; GO:0046331; GO:0007616; GO:0035170; GO:0007498; GO:0008045; GO:0007521; GO:0046329; GO:0045316; GO:0035157; GO:0050768; GO:0035155; GO:0000122; GO:0007400; GO:0005654; GO:0007314; GO:0030720; GO:0030713; GO:0007422; GO:1900087; GO:0045747; GO:0008284; GO:0045944; GO:0043234; GO:0045468; GO:0042686; GO:0042689; GO:0051489; GO:0040008; GO:0009608; GO:0016330; GO:0007519; GO:0035003; GO:0006351; GO:0004888; GO:0007419; GO:0048190; GO:0007473 Q24279; P10041; P28159 "Golgi lumen; Malpighian tubule tip cell differentiation; Notch signaling pathway; R1/R6 cell differentiation; R3/R4 cell fate commitment; R7 cell differentiation; R8 cell development; R8 cell fate commitment; actin filament organization; adherens junction; asymmetric cell division; border follicle cell migration; calcium ion binding; cell surface; chaeta morphogenesis; chromatin binding; compound eye cone cell fate commitment; compound eye retinal cell programmed cell death; cytosol; determination of adult lifespan; dorsal appendage formation; dorsal closure; dorsal/ventral lineage restriction, imaginal disc; ectoderm development; embryonic crystal cell differentiation; endoplasmic reticulum lumen; endosome; epithelial cell proliferation involved in Malpighian tubule morphogenesis; epithelial cell type specification, open tracheal system; eye-antennal disc development; foregut morphogenesis; formation of a compartment boundary; germ-line stem cell maintenance; germarium-derived female germ-line cyst encapsulation; glial cell fate determination; glial cell migration; hemocyte proliferation; heterophilic cell-cell adhesion; imaginal disc growth; imaginal disc-derived leg joint morphogenesis; imaginal disc-derived male genitalia morphogenesis; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein specification; integral to membrane; lamellocyte differentiation; lateral inhibition; long-term memory; lymph gland crystal cell differentiation; mesoderm development; motor neuron axon guidance; muscle cell fate determination; negative regulation of JNK cascade; negative regulation of compound eye photoreceptor development; negative regulation of fusion cell fate specification; negative regulation of neurogenesis; negative regulation of terminal cell fate specification, open tracheal system; negative regulation of transcription from RNA polymerase II promoter; neuroblast fate determination; nucleoplasm; oocyte anterior/posterior axis specification; oocyte localization involved in germarium-derived egg chamber formation; ovarian follicle cell stalk formation; peripheral nervous system development; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of Notch signaling pathway; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; protein complex; regulation of R8 cell spacing in compound eye; regulation of cardioblast cell fate specification; regulation of crystal cell differentiation; regulation of filopodium assembly; regulation of growth; response to symbiont; second mitotic wave involved in compound eye morphogenesis; skeletal muscle tissue development; subapical complex; transcription, DNA-dependent; transmembrane signaling receptor activity; ventral cord development; wing disc dorsal/ventral pattern formation; wing disc proximal/distal pattern formation" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR000800; IPR010660; IPR011656; Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) TR36047_c1_g1_i3 P07225 PROS_HUMAN 8.00E-12 GO:0005796; GO:0000139; GO:0005509; GO:0004866; GO:0005789; GO:0005576; GO:0042730; GO:0045087; GO:0050900; GO:0017187; GO:0030168; GO:0031093; GO:0002576; GO:0043687; GO:0006508; GO:0030449 Golgi lumen; Golgi membrane; calcium ion binding; endopeptidase inhibitor activity; endoplasmic reticulum membrane; extracellular region; fibrinolysis; innate immune response; leukocyte migration; peptidyl-glutamic acid carboxylation; platelet activation; platelet alpha granule lumen; platelet degranulation; post-translational protein modification; proteolysis; regulation of complement activation IPR017857; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR000294; IPR009030; IPR001791; Vitamin K-dependent protein S PROS1 PROS Homo sapiens (Human) TR36047_c2_g5_i3 Q5GFL6 VWA2_HUMAN 1.00E-05 GO:0005576 extracellular region IPR000742; IPR013032; IPR002035; von Willebrand factor A domain-containing protein 2 (A domain-containing protein similar to matrilin and collagen) (AMACO) (Colon cancer secreted protein 2) (CCSP-2) VWA2 AMACO Homo sapiens (Human) TR36047_c2_g5_i4 Q6V0I7 FAT4_HUMAN 2.00E-12 GO:0005509; GO:0007156; GO:0016021; GO:0005886 Q9H2K2 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) TR36048_c1_g1_i1 Q0VGK4 GDPD1_RAT 4.00E-108 GO:0006071; GO:0008889; GO:0016021; GO:0006629; GO:0046872 glycerol metabolic process; glycerophosphodiester phosphodiesterase activity; integral to membrane; lipid metabolic process; metal ion binding IPR004129; IPR017946; Glycerophosphodiester phosphodiesterase domain-containing protein 1 (EC 3.1.-.-) Gdpd1 Rattus norvegicus (Rat) TR36051_c1_g2_i1 Q9TTY2 FER_CANFA 6.00E-158 GO:0005524; GO:0005938; GO:0030054; GO:0042995; GO:0005856; GO:0008289; GO:0004715; GO:0005634; GO:0005886 ATP binding; cell cortex; cell junction; cell projection; cytoskeleton; lipid binding; non-membrane spanning protein tyrosine kinase activity; nucleus; plasma membrane IPR001060; IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR008266; IPR020635; IPR016250; Tyrosine-protein kinase Fer (EC 2.7.10.2) (Proto-oncogene c-Fer) (p94-Fer) FER Canis familiaris (Dog) (Canis lupus familiaris) TR36051_c1_g2_i3 P18106 FPS_DROME 1.00E-151 GO:0005524; GO:0051017; GO:0005912; GO:0007411; GO:0046664; GO:0007394; GO:0004715; GO:0005886; GO:0004713 "ATP binding; actin filament bundle assembly; adherens junction; axon guidance; dorsal closure, amnioserosa morphology change; dorsal closure, elongation of leading edge cells; non-membrane spanning protein tyrosine kinase activity; plasma membrane; protein tyrosine kinase activity" IPR001060; IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR008266; IPR020635; Tyrosine-protein kinase Fps85D (EC 2.7.10.2) (dFer) Fps85D Fer fps HD-179 CG8874 Drosophila melanogaster (Fruit fly) TR36051_c1_g2_i4 P16591 FER_HUMAN 0 GO:0005524; GO:0038095; GO:0038109; GO:0031532; GO:0005938; GO:0030054; GO:0042995; GO:0008283; GO:0044331; GO:0036006; GO:0034614; GO:0006935; GO:0005856; GO:0005829; GO:0050904; GO:0005154; GO:0035426; GO:0031234; GO:0038028; GO:0070102; GO:0008289; GO:0000226; GO:0000278; GO:0033007; GO:0004715; GO:0005634; GO:0048008; GO:0051092; GO:0030838; GO:0030335; GO:0008284; GO:0046777; GO:0042058; GO:0010762; GO:0010591; GO:0001932; GO:0032496; GO:0036119; GO:0034446; GO:0042503 O42486 ATP binding; Fc-epsilon receptor signaling pathway; Kit signaling pathway; actin cytoskeleton reorganization; cell cortex; cell junction; cell projection; cell proliferation; cell-cell adhesion mediated by cadherin; cellular response to macrophage colony-stimulating factor stimulus; cellular response to reactive oxygen species; chemotaxis; cytoskeleton; cytosol; diapedesis; epidermal growth factor receptor binding; extracellular matrix-cell signaling; extrinsic to internal side of plasma membrane; insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade; interleukin-6-mediated signaling pathway; lipid binding; microtubule cytoskeleton organization; mitotic cell cycle; negative regulation of mast cell activation involved in immune response; non-membrane spanning protein tyrosine kinase activity; nucleus; platelet-derived growth factor receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; positive regulation of actin filament polymerization; positive regulation of cell migration; positive regulation of cell proliferation; protein autophosphorylation; regulation of epidermal growth factor receptor signaling pathway; regulation of fibroblast migration; regulation of lamellipodium assembly; regulation of protein phosphorylation; response to lipopolysaccharide; response to platelet-derived growth factor stimulus; substrate adhesion-dependent cell spreading; tyrosine phosphorylation of Stat3 protein IPR001060; IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR008266; IPR020635; IPR016250; Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer) FER TYK3 Homo sapiens (Human) TR36051_c2_g2_i1 Q99LL5 PWP1_MOUSE 2.00E-128 GO:0005634 nucleus IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Periodic tryptophan protein 1 homolog Pwp1 Mus musculus (Mouse) TR36053_c3_g3_i1 Q9D8U4 C1QT2_MOUSE 2.00E-06 GO:0000187; GO:0005581; GO:0005615; GO:0042802; GO:0046321; GO:0046326; GO:0045725; GO:0070208; GO:0051260; GO:0005102 activation of MAPK activity; collagen; extracellular space; identical protein binding; positive regulation of fatty acid oxidation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; protein heterotrimerization; protein homooligomerization; receptor binding IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 2 (mCTRP2) C1qtnf2 Crtp2 Mus musculus (Mouse) TR36053_c3_g3_i2 P31722 C1QC_RAT 3.00E-07 GO:0005581; GO:0006958; GO:0045087; GO:0030853; GO:0045650 "collagen; complement activation, classical pathway; innate immune response; negative regulation of granulocyte differentiation; negative regulation of macrophage differentiation" IPR001073; IPR008160; IPR008983; Complement C1q subcomponent subunit C C1qc C1qg Rattus norvegicus (Rat) TR36053_c3_g3_i3 P25067 CO8A2_HUMAN 2.00E-07 GO:0001525; GO:0005604; GO:0048593; GO:0016337; GO:0005581; GO:0030574; GO:0005788; GO:0050673; GO:0022617; GO:0005201; GO:0030674 "angiogenesis; basement membrane; camera-type eye morphogenesis; cell-cell adhesion; collagen; collagen catabolic process; endoplasmic reticulum lumen; epithelial cell proliferation; extracellular matrix disassembly; extracellular matrix structural constituent; protein binding, bridging" IPR001073; IPR008160; IPR008983; Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) TR36053_c3_g3_i5 Q9D8U4 C1QT2_MOUSE 3.00E-07 GO:0000187; GO:0005581; GO:0005615; GO:0042802; GO:0046321; GO:0046326; GO:0045725; GO:0070208; GO:0051260; GO:0005102 activation of MAPK activity; collagen; extracellular space; identical protein binding; positive regulation of fatty acid oxidation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; protein heterotrimerization; protein homooligomerization; receptor binding IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 2 (mCTRP2) C1qtnf2 Crtp2 Mus musculus (Mouse) TR36055_c0_g1_i1 P56812 PDCD5_MOUSE 4.00E-31 GO:0003677; GO:0006915; GO:0005737; GO:0005634; GO:0043065 DNA binding; apoptotic process; cytoplasm; nucleus; positive regulation of apoptotic process IPR002836; Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19) Pdcd5 Tfar19 Mus musculus (Mouse) TR36056_c0_g1_i1 Q5F3N6 BAP1_CHICK 3.00E-07 GO:0035517; GO:0003682; GO:0005737; GO:0035522; GO:0071108; GO:0051726; GO:0001558; GO:0004221; GO:0006511; GO:0004843 PR-DUB complex; chromatin binding; cytoplasm; monoubiquitinated histone H2A deubiquitination; protein K48-linked deubiquitination; regulation of cell cycle; regulation of cell growth; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR001578; Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) BAP1 RCJMB04_11f19 Gallus gallus (Chicken) TR36056_c3_g1_i1 O50655 XERD_SELRU 3.00E-08 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR36056_c6_g3_i2 Q4V8D1 CP2U1_RAT 1.00E-48 GO:0070330; GO:0005789; GO:0020037; GO:0016021; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 2U1 (EC 1.14.14.1) Cyp2u1 Rattus norvegicus (Rat) TR36056_c6_g3_i6 P51589 CP2J2_HUMAN 2.00E-63 GO:0008405; GO:0008404; GO:0070330; GO:0005789; GO:0019373; GO:0020037; GO:0005506; GO:0071614; GO:0043651; GO:0008016; GO:0006805 "arachidonic acid 11,12-epoxygenase activity; arachidonic acid 14,15-epoxygenase activity; aromatase activity; endoplasmic reticulum membrane; epoxygenase P450 pathway; heme binding; iron ion binding; linoleic acid epoxygenase activity; linoleic acid metabolic process; regulation of heart contraction; xenobiotic metabolic process" IPR001128; IPR017972; IPR002401; IPR008071; Cytochrome P450 2J2 (EC 1.14.14.1) (Arachidonic acid epoxygenase) (CYPIIJ2) CYP2J2 Homo sapiens (Human) TR36057_c1_g1_i1 Q0P4H0 ADAT2_XENTR 9.00E-31 GO:0016787; GO:0008033; GO:0008270 hydrolase activity; tRNA processing; zinc ion binding IPR016192; IPR002125; IPR016193; tRNA-specific adenosine deaminase 2 (EC 3.5.4.-) (Deaminase domain-containing protein 1) (tRNA-specific adenosine-34 deaminase subunit ADAT2) adat2 deadc1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36057_c2_g1_i1 Q8GWA1 NDA1_ARATH 3.00E-115 GO:0003954; GO:0003959; GO:0071482; GO:0050660; GO:0031304; GO:0005759; GO:0005777 NADH dehydrogenase activity; NADPH dehydrogenase activity; cellular response to light stimulus; flavin adenine dinucleotide binding; intrinsic to mitochondrial inner membrane; mitochondrial matrix; peroxisome IPR013027; IPR023753; IPR001327; "Internal alternative NAD(P)H-ubiquinone oxidoreductase A1, mitochondrial (EC 1.6.5.9) (Internal alternative NADH dehydrogenase NDA1) (Internal non-phosphorylating NAD(P)H dehydrogenase 1) (AtNDI1) (NADH:ubiquinone reductase (non-electrogenic) NDA1)" NDA1 NDI1 At1g07180 F10K1.11 Arabidopsis thaliana (Mouse-ear cress) TR36057_c2_g1_i3 P40215 NDH1_YEAST 7.00E-82 GO:0003954; GO:0006116; GO:0001300; GO:0050660; GO:0019655; GO:0005758; GO:0005739 P10592 NADH dehydrogenase activity; NADH oxidation; chronological cell aging; flavin adenine dinucleotide binding; glucose catabolic process to ethanol; mitochondrial intermembrane space; mitochondrion IPR013027; IPR023753; IPR001327; "External NADH-ubiquinone oxidoreductase 1, mitochondrial (EC 1.6.5.9) (External NADH dehydrogenase 1)" NDE1 NDH1 YMR145C YM9375.14C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR36058_c2_g1_i1 Q6PFX9 TNKS1_MOUSE 4.00E-07 GO:0005794; GO:0000139; GO:0003950; GO:0016055; GO:0051301; GO:0000775; GO:0051028; GO:0007067; GO:0043392; GO:0000784; GO:0005643; GO:0018105; GO:0018107; GO:0090263; GO:0032212; GO:0045944; GO:0070213; GO:0070198; GO:0070212; GO:0000209; GO:0015031; GO:0000922; GO:0008270 "Golgi apparatus; Golgi membrane; NAD+ ADP-ribosyltransferase activity; Wnt receptor signaling pathway; cell division; chromosome, centromeric region; mRNA transport; mitosis; negative regulation of DNA binding; nuclear chromosome, telomeric region; nuclear pore; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of telomere maintenance via telomerase; positive regulation of transcription from RNA polymerase II promoter; protein auto-ADP-ribosylation; protein localization to chromosome, telomeric region; protein poly-ADP-ribosylation; protein polyubiquitination; protein transport; spindle pole; zinc ion binding" IPR002110; IPR020683; IPR012317; IPR001660; IPR013761; IPR011510; Tankyrase-1 (TANK1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (TRF1-interacting ankyrin-related ADP-ribose polymerase 1) (Tankyrase I) Tnks Tnks1 Mus musculus (Mouse) TR36058_c2_g1_i2 Q62415 ASPP1_MOUSE 3.00E-84 GO:0005737; GO:0072332; GO:0045786; GO:0005634; GO:0005886 cytoplasm; intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of cell cycle; nucleus; plasma membrane IPR002110; IPR020683; IPR028319; IPR001452; Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B) Ppp1r13b Aspp1 Mus musculus (Mouse) TR36059_c1_g2_i4 Q8N8S7 ENAH_HUMAN 1.00E-44 GO:0050852; GO:0008154; GO:0007411; GO:0005829; GO:0030175; GO:0005925; GO:0046907; GO:0030027; GO:0001843; GO:0005886; GO:0001725; GO:0045202 Q14517 T cell receptor signaling pathway; actin polymerization or depolymerization; axon guidance; cytosol; filopodium; focal adhesion; intracellular transport; lamellipodium; neural tube closure; plasma membrane; stress fiber; synapse IPR011993; IPR000156; IPR014885; IPR000697; Protein enabled homolog ENAH MENA Homo sapiens (Human) TR36060_c1_g1_i1 P82102 MYNB_MYTGA 8.00E-06 GO:0042742; GO:0050832; GO:0005576; GO:0031640 defense response to bacterium; defense response to fungus; extracellular region; killing of cells of other organism IPR019631; Myticin-B Mytilus galloprovincialis (Mediterranean mussel) TR36061_c0_g1_i1 P56389 CDD_MOUSE 9.00E-54 GO:0004126; GO:0030308; GO:0045980; GO:0001882; GO:0042803; GO:0051289; GO:0008270 cytidine deaminase activity; negative regulation of cell growth; negative regulation of nucleotide metabolic process; nucleoside binding; protein homodimerization activity; protein homotetramerization; zinc ion binding IPR016192; IPR002125; IPR006262; IPR016193; Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) Cda Cdd Mus musculus (Mouse) TR36061_c0_g1_i10 P56389 CDD_MOUSE 8.00E-54 GO:0004126; GO:0030308; GO:0045980; GO:0001882; GO:0042803; GO:0051289; GO:0008270 cytidine deaminase activity; negative regulation of cell growth; negative regulation of nucleotide metabolic process; nucleoside binding; protein homodimerization activity; protein homotetramerization; zinc ion binding IPR016192; IPR002125; IPR006262; IPR016193; Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) Cda Cdd Mus musculus (Mouse) TR36061_c0_g1_i11 P32320 CDD_HUMAN 9.00E-56 GO:0007166; GO:0004126; GO:0019858; GO:0005829; GO:0005576; GO:0030308; GO:0045980; GO:0001882; GO:0042803; GO:0051289; GO:0043097; GO:0008270 cell surface receptor signaling pathway; cytidine deaminase activity; cytosine metabolic process; cytosol; extracellular region; negative regulation of cell growth; negative regulation of nucleotide metabolic process; nucleoside binding; protein homodimerization activity; protein homotetramerization; pyrimidine nucleoside salvage; zinc ion binding IPR016192; IPR002125; IPR006262; IPR016193; Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) CDA CDD Homo sapiens (Human) TR36061_c0_g1_i3 Q7MK48 CDD_VIBVY 6.00E-09 GO:0004126; GO:0008270 cytidine deaminase activity; zinc ion binding IPR016192; IPR002125; IPR013171; IPR006263; IPR016193; IPR020797; Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) (CDA) cdd VV1962 Vibrio vulnificus (strain YJ016) TR36061_c0_g1_i6 Q06549 CDD_YEAST 8.00E-24 GO:0004126; GO:0005737; GO:0006217; GO:0005634; GO:0008655; GO:0008270 Itself cytidine deaminase activity; cytoplasm; deoxycytidine catabolic process; nucleus; pyrimidine-containing compound salvage; zinc ion binding IPR016192; IPR002125; IPR006262; IPR016193; Cytidine deaminase (CDA) (EC 3.5.4.5) (Cytidine aminohydrolase) CDD1 YLR245C L9672.13 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR36061_c0_g1_i7 Q09190 CDD_SCHPO 3.00E-29 GO:0004126; GO:0005829; GO:0005634; GO:0006206; GO:0008270 cytidine deaminase activity; cytosol; nucleus; pyrimidine nucleobase metabolic process; zinc ion binding IPR016192; IPR002125; IPR006262; IPR016193; Putative cytidine deaminase (CDA) (EC 3.5.4.5) (Cytidine aminohydrolase) pcd1 SPAC1556.04c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36061_c0_g1_i9 P33967 BSR_BACCE 3.00E-07 GO:0047711; GO:0008152; GO:0046677; GO:0008270 blasticidin-S deaminase activity; metabolic process; response to antibiotic; zinc ion binding IPR016192; IPR002125; IPR016193; Blasticidin-S deaminase (EC 3.5.4.23) bsr Bacillus cereus TR36063_c2_g1_i1 Q9Y6C2 EMIL1_HUMAN 1.00E-06 GO:0007155; GO:0005581; GO:0030023; GO:0030198; GO:0070062; GO:0010811 cell adhesion; collagen; extracellular matrix constituent conferring elasticity; extracellular matrix organization; extracellular vesicular exosome; positive regulation of cell-substrate adhesion IPR001073; IPR008160; IPR011489; IPR008983; EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1) EMILIN1 EMI Homo sapiens (Human) TR36063_c2_g1_i3 Q6IR41 C1QT6_MOUSE 9.00E-06 GO:0005581; GO:0005615; GO:0042802; GO:0070208 collagen; extracellular space; identical protein binding; protein heterotrimerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 6 C1qtnf6 Mus musculus (Mouse) TR36063_c2_g1_i6 P83425 HIP_MYTED 3.00E-07 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR36064_c0_g3_i5 Q9LSS7 RUBP1_ARATH 1.00E-33 GO:0019784; GO:0006508 NEDD8-specific protease activity; proteolysis IPR003653; NEDD8-specific protease 1 (EC 3.4.22.68) (Deneddylase-1) NEDP1 DEN1 At5g60190 F15L12.8 Arabidopsis thaliana (Mouse-ear cress) TR36064_c0_g3_i6 Q96LD8 SENP8_HUMAN 1.00E-51 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR003653; "Sentrin-specific protease 8 (EC 3.4.22.68) (Deneddylase-1) (NEDD8-specific protease 1) (Protease, cysteine 2) (Sentrin/SUMO-specific protease SENP8)" SENP8 DEN1 NEDP1 PRSC2 FKSG8 Homo sapiens (Human) TR36064_c0_g8_i1 Q5FVJ8 SENP8_RAT 9.00E-31 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR003653; Sentrin-specific protease 8 (EC 3.4.22.68) (Deneddylase-1) (NEDD8-specific protease 1) (Sentrin/SUMO-specific protease SENP8) Senp8 Rattus norvegicus (Rat) TR36065_c0_g2_i1 O75751 S22A3_HUMAN 3.00E-80 GO:0005329; GO:0015872; GO:0006855; GO:0051615; GO:0005887; GO:0015651; GO:0032098; GO:0044281; GO:1901998; GO:0019534 P00519 dopamine transmembrane transporter activity; dopamine transport; drug transmembrane transport; histamine uptake; integral to plasma membrane; quaternary ammonium group transmembrane transporter activity; regulation of appetite; small molecule metabolic process; toxin transport; toxin transporter activity IPR011701; IPR020846; IPR016196; IPR004749; IPR005829; Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3) SLC22A3 EMTH OCT3 Homo sapiens (Human) TR36067_c2_g1_i2 P97571 CAN1_RAT 7.00E-136 GO:0005509; GO:0004198; GO:0005737; GO:0008092; GO:0005886; GO:0016540; GO:0006508 calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cytoplasm; cytoskeletal protein binding; plasma membrane; protein autoprocessing; proteolysis IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Micromolar-calpain) (muCANP) Capn1 Cls1 Rattus norvegicus (Rat) TR36069_c1_g3_i1 Q06124 PTN11_HUMAN 0 GO:0000077; GO:0038095; GO:0005070; GO:0031295; GO:0000187; GO:0036302; GO:0007411; GO:0007596; GO:0007420; GO:0005829; GO:0048013; GO:0007173; GO:0060325; GO:0008543; GO:0048806; GO:0042593; GO:0042445; GO:0009755; GO:0048839; GO:0008286; GO:0060333; GO:0050900; GO:0005739; GO:0048609; GO:0051463; GO:0060125; GO:0046676; GO:0048011; GO:0004726; GO:0005634; GO:0035265; GO:0048015; GO:2001275; GO:0046887; GO:0043234; GO:0033628; GO:0060334; GO:0040014; GO:0046825; GO:0060338; GO:0006641; GO:0060337 P32239; P20138; Q08345; P68105; Q71V39; P04626; P17948; Q13480; Q9UQC2; P62993; P08069; P06213; P35568; P35570; P43628; O95297; P09619; P16284; P49023; P97710 DNA damage checkpoint; Fc-epsilon receptor signaling pathway; SH3/SH2 adaptor activity; T cell costimulation; activation of MAPK activity; atrioventricular canal development; axon guidance; blood coagulation; brain development; cytosol; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; face morphogenesis; fibroblast growth factor receptor signaling pathway; genitalia development; glucose homeostasis; hormone metabolic process; hormone-mediated signaling pathway; inner ear development; insulin receptor signaling pathway; interferon-gamma-mediated signaling pathway; leukocyte migration; mitochondrion; multicellular organismal reproductive process; negative regulation of cortisol secretion; negative regulation of growth hormone secretion; negative regulation of insulin secretion; neurotrophin TRK receptor signaling pathway; non-membrane spanning protein tyrosine phosphatase activity; nucleus; organ growth; phosphatidylinositol-mediated signaling; positive regulation of glucose import in response to insulin stimulus; positive regulation of hormone secretion; protein complex; regulation of cell adhesion mediated by integrin; regulation of interferon-gamma-mediated signaling pathway; regulation of multicellular organism growth; regulation of protein export from nucleus; regulation of type I interferon-mediated signaling pathway; triglyceride metabolic process; type I interferon-mediated signaling pathway IPR000980; IPR000387; IPR016130; IPR012152; IPR000242; Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3) PTPN11 PTP2C SHPTP2 Homo sapiens (Human) TR36069_c1_g3_i2 Q06124 PTN11_HUMAN 0 GO:0000077; GO:0038095; GO:0005070; GO:0031295; GO:0000187; GO:0036302; GO:0007411; GO:0007596; GO:0007420; GO:0005829; GO:0048013; GO:0007173; GO:0060325; GO:0008543; GO:0048806; GO:0042593; GO:0042445; GO:0009755; GO:0048839; GO:0008286; GO:0060333; GO:0050900; GO:0005739; GO:0048609; GO:0051463; GO:0060125; GO:0046676; GO:0048011; GO:0004726; GO:0005634; GO:0035265; GO:0048015; GO:2001275; GO:0046887; GO:0043234; GO:0033628; GO:0060334; GO:0040014; GO:0046825; GO:0060338; GO:0006641; GO:0060337 P32239; P20138; Q08345; P68105; Q71V39; P04626; P17948; Q13480; Q9UQC2; P62993; P08069; P06213; P35568; P35570; P43628; O95297; P09619; P16284; P49023; P97710 DNA damage checkpoint; Fc-epsilon receptor signaling pathway; SH3/SH2 adaptor activity; T cell costimulation; activation of MAPK activity; atrioventricular canal development; axon guidance; blood coagulation; brain development; cytosol; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; face morphogenesis; fibroblast growth factor receptor signaling pathway; genitalia development; glucose homeostasis; hormone metabolic process; hormone-mediated signaling pathway; inner ear development; insulin receptor signaling pathway; interferon-gamma-mediated signaling pathway; leukocyte migration; mitochondrion; multicellular organismal reproductive process; negative regulation of cortisol secretion; negative regulation of growth hormone secretion; negative regulation of insulin secretion; neurotrophin TRK receptor signaling pathway; non-membrane spanning protein tyrosine phosphatase activity; nucleus; organ growth; phosphatidylinositol-mediated signaling; positive regulation of glucose import in response to insulin stimulus; positive regulation of hormone secretion; protein complex; regulation of cell adhesion mediated by integrin; regulation of interferon-gamma-mediated signaling pathway; regulation of multicellular organism growth; regulation of protein export from nucleus; regulation of type I interferon-mediated signaling pathway; triglyceride metabolic process; type I interferon-mediated signaling pathway IPR000980; IPR000387; IPR016130; IPR012152; IPR000242; Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3) PTPN11 PTP2C SHPTP2 Homo sapiens (Human) TR36069_c1_g3_i3 P81718 PTN6_RAT 0 GO:0030154; GO:0008283; GO:0005737; GO:0005634; GO:0070372; GO:0009611; GO:0005001 cell differentiation; cell proliferation; cytoplasm; nucleus; regulation of ERK1 and ERK2 cascade; response to wounding; transmembrane receptor protein tyrosine phosphatase activity IPR000980; IPR000387; IPR016130; IPR012152; IPR000242; Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase SHP-1) Ptpn6 Ptph6 Rattus norvegicus (Rat) TR36069_c1_g3_i4 Q5ICW4 GRB14_BOVIN 2.00E-06 GO:0000139; GO:0010008; GO:0005543; GO:0007165 P29973; Q14028 Golgi membrane; endosome membrane; phospholipid binding; signal transduction IPR015042; IPR011993; IPR001849; IPR000159; IPR000980; Growth factor receptor-bound protein 14 (GRB14 adapter protein) GRB14 Bos taurus (Bovine) TR36073_c0_g6_i2 O02467 ASPG_SPOFR 2.00E-111 GO:0003948; GO:0005764; GO:0008233; GO:0006508 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity; lysosome; peptidase activity; proteolysis IPR000246; N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (AGA) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain] (Fragment) Spodoptera frugiperda (Fall armyworm) TR36073_c0_g6_i4 Q32LE5 ASGL1_BOVIN 9.00E-21 GO:0004067; GO:0033345; GO:0008798; GO:0005737; GO:0015630; GO:0005634; GO:0006508 asparaginase activity; asparagine catabolic process via L-aspartate; beta-aspartyl-peptidase activity; cytoplasm; microtubule cytoskeleton; nucleus; proteolysis IPR000246; Isoaspartyl peptidase/L-asparaginase (EC 3.4.19.5) (EC 3.5.1.1) (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain] ASRGL1 Bos taurus (Bovine) TR36074_c0_g1_i1 Q9US38 YFZ3_SCHPO 1.00E-10 GO:0005829; GO:0016787; GO:0005634 cytosol; hydrolase activity; nucleus IPR013094; AB hydrolase superfamily protein C1039.03 (EC 3.-.-.-) SPAC1039.03 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36074_c0_g1_i2 Q9US38 YFZ3_SCHPO 8.00E-29 GO:0005829; GO:0016787; GO:0005634 cytosol; hydrolase activity; nucleus IPR013094; AB hydrolase superfamily protein C1039.03 (EC 3.-.-.-) SPAC1039.03 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36075_c1_g1_i1 Q14997 PSME4_HUMAN 0 GO:0006977; GO:0006281; GO:0031145; GO:0002479; GO:0006915; GO:0005829; GO:0010467; GO:0070577; GO:0016071; GO:0007275; GO:0043066; GO:0016607; GO:0005634; GO:0016504; GO:0051437; GO:0010499; GO:0000209; GO:0006521; GO:0044281; GO:0035093; GO:1990111; GO:0016032 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA repair; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic process; cytosol; gene expression; histone acetyl-lysine binding; mRNA metabolic process; multicellular organismal development; negative regulation of apoptotic process; nuclear speck; nucleus; peptidase activator activity; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; proteasomal ubiquitin-independent protein catabolic process; protein polyubiquitination; regulation of cellular amino acid metabolic process; small molecule metabolic process; spermatogenesis, exchange of chromosomal proteins; spermatoproteasome complex; viral process" IPR011989; IPR016024; IPR021843; Proteasome activator complex subunit 4 (Proteasome activator PA200) PSME4 KIAA0077 Homo sapiens (Human) TR36075_c1_g1_i2 Q5SSW2 PSME4_MOUSE 0 GO:0006281; GO:0005829; GO:0070577; GO:0007275; GO:0016607; GO:0005634; GO:0016504; GO:0010499; GO:0035093; GO:1990111 "DNA repair; cytosol; histone acetyl-lysine binding; multicellular organismal development; nuclear speck; nucleus; peptidase activator activity; proteasomal ubiquitin-independent protein catabolic process; spermatogenesis, exchange of chromosomal proteins; spermatoproteasome complex" IPR011989; IPR016024; IPR021843; Proteasome activator complex subunit 4 (Proteasome activator PA200) (Protein TEMO) Psme4 Kiaa0077 Mus musculus (Mouse) TR36076_c0_g1_i1 P42577 FRIS_LYMST 7.00E-77 GO:0006879; GO:0005737; GO:0008199; GO:0004322; GO:0006826 cellular iron ion homeostasis; cytoplasm; ferric iron binding; ferroxidase activity; iron ion transport IPR001519; IPR009040; IPR009078; IPR012347; IPR014034; IPR008331; Soma ferritin (EC 1.16.3.1) Lymnaea stagnalis (Great pond snail) TR36077_c0_g1_i1 Q90334 ITR_CATCO 1.00E-18 GO:0016021; GO:0004990; GO:0005886; GO:0005000 integral to membrane; oxytocin receptor activity; plasma membrane; vasopressin receptor activity IPR000276; IPR017452; IPR002062; IPR001817; Isotocin receptor (ITR) Catostomus commersonii (White sucker) TR36077_c0_g1_i2 Q868T3 CCAPR_DROME 1.00E-17 GO:0018990; GO:0005887; GO:0008188; GO:0005000 "ecdysis, chitin-based cuticle; integral to plasma membrane; neuropeptide receptor activity; vasopressin receptor activity" IPR000276; IPR017452; IPR001817; Cardioacceleratory peptide receptor CcapR CG6111 Drosophila melanogaster (Fruit fly) TR36077_c0_g1_i4 Q868T3 CCAPR_DROME 2.00E-17 GO:0018990; GO:0005887; GO:0008188; GO:0005000 "ecdysis, chitin-based cuticle; integral to plasma membrane; neuropeptide receptor activity; vasopressin receptor activity" IPR000276; IPR017452; IPR001817; Cardioacceleratory peptide receptor CcapR CG6111 Drosophila melanogaster (Fruit fly) TR36077_c0_g1_i6 O88416 GPR33_MOUSE 1.00E-10 GO:0004982; GO:0016021; GO:0005886 N-formyl peptide receptor activity; integral to membrane; plasma membrane IPR000826; IPR000276; IPR017452; Probable G-protein coupled receptor 33 Gpr33 Mus musculus (Mouse) TR36077_c0_g1_i7 Q90334 ITR_CATCO 2.00E-19 GO:0016021; GO:0004990; GO:0005886; GO:0005000 integral to membrane; oxytocin receptor activity; plasma membrane; vasopressin receptor activity IPR000276; IPR017452; IPR002062; IPR001817; Isotocin receptor (ITR) Catostomus commersonii (White sucker) TR36082_c0_g1_i2 Q24306 IAP1_DROME 1.00E-13 GO:0019788; GO:0016055; GO:0048800; GO:0007298; GO:0008407; GO:0004869; GO:0005737; GO:0008354; GO:0097340; GO:1990001; GO:0043066; GO:0046673; GO:0005634; GO:0090263; GO:0031398; GO:0042787; GO:0045035; GO:0007289; GO:0004842; GO:0008270 P25843; Q86PE7; Q9XYF4; Q24475; Q24106 NEDD8 ligase activity; Wnt receptor signaling pathway; antennal morphogenesis; border follicle cell migration; chaeta morphogenesis; cysteine-type endopeptidase inhibitor activity; cytoplasm; germ cell migration; inhibition of cysteine-type endopeptidase activity; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of compound eye retinal cell programmed cell death; nucleus; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; sensory organ precursor cell division; spermatid nucleus differentiation; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; Apoptosis 1 inhibitor (EC 6.3.2.-) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (dIAP1) (Protein thread) th Iap1 CG12284 Drosophila melanogaster (Fruit fly) TR36082_c0_g1_i4 Q24306 IAP1_DROME 7.00E-08 GO:0019788; GO:0016055; GO:0048800; GO:0007298; GO:0008407; GO:0004869; GO:0005737; GO:0008354; GO:0097340; GO:1990001; GO:0043066; GO:0046673; GO:0005634; GO:0090263; GO:0031398; GO:0042787; GO:0045035; GO:0007289; GO:0004842; GO:0008270 P25843; Q86PE7; Q9XYF4; Q24475; Q24106 NEDD8 ligase activity; Wnt receptor signaling pathway; antennal morphogenesis; border follicle cell migration; chaeta morphogenesis; cysteine-type endopeptidase inhibitor activity; cytoplasm; germ cell migration; inhibition of cysteine-type endopeptidase activity; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of compound eye retinal cell programmed cell death; nucleus; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; sensory organ precursor cell division; spermatid nucleus differentiation; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; Apoptosis 1 inhibitor (EC 6.3.2.-) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (dIAP1) (Protein thread) th Iap1 CG12284 Drosophila melanogaster (Fruit fly) TR36082_c0_g1_i5 P41437 IAP3_NPVOP 2.00E-11 GO:0006915; GO:0016874; GO:0039648; GO:0008270 apoptotic process; ligase activity; modulation by virus of host protein ubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; E3 ubiquitin-protein ligase IAP-3 (EC 6.3.2.-) (IAP-3) IAP3 IAP ORF35 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) TR36084_c0_g1_i3 Q9W549 APOP1_DROME 2.00E-21 GO:0005739 Q9VLJ8 mitochondrion IPR018796; "APOPT family protein CG14806, mitochondrial" CG14806 Drosophila melanogaster (Fruit fly) TR36084_c0_g1_i4 Q32Q90 APOP1_RAT 1.00E-32 GO:0006915; GO:0005739 apoptotic process; mitochondrion IPR018796; "Apoptogenic protein 1, mitochondrial (APOP-1)" Apopt1 Apop1 Rattus norvegicus (Rat) TR36085_c3_g1_i1 O77808 V2R_CANFA 9.00E-18 GO:0007249; GO:0016021; GO:0032609; GO:0005886; GO:0010628; GO:0034097; GO:0005000 I-kappaB kinase/NF-kappaB cascade; integral to membrane; interferon-gamma production; plasma membrane; positive regulation of gene expression; response to cytokine stimulus; vasopressin receptor activity IPR000276; IPR017452; IPR001817; IPR000161; Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor) AVPR2 V2R Canis familiaris (Dog) (Canis lupus familiaris) TR36085_c3_g1_i11 Q95MH6 GNRR2_CHLAE 3.00E-06 GO:0097211; GO:0004968; GO:0016021; GO:0005886 cellular response to gonadotropin-releasing hormone; gonadotropin-releasing hormone receptor activity; integral to membrane; plasma membrane IPR000276; IPR017452; IPR027983; IPR001658; Gonadotropin-releasing hormone II receptor (GnRH II receptor) (GnRH-II-R) (Type II GnRH receptor) GNRHR2 Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) TR36085_c3_g1_i12 P30560 V1AR_RAT 3.00E-07 GO:0031894; GO:0019722; GO:0042631; GO:0031410; GO:0030659; GO:0007204; GO:0007625; GO:0016021; GO:0002125; GO:0042711; GO:0014902; GO:0007621; GO:0051970; GO:0043084; GO:0017046; GO:0005886; GO:0030307; GO:0008284; GO:0032849; GO:0014049; GO:0045819; GO:0010460; GO:0031394; GO:0035815; GO:0003084; GO:0035810; GO:0045907; GO:0051459; GO:0001992; GO:0051412; GO:0035176; GO:0042713; GO:0021537; GO:0005000 V1A vasopressin receptor binding; calcium-mediated signaling; cellular response to water deprivation; cytoplasmic vesicle; cytoplasmic vesicle membrane; elevation of cytosolic calcium ion concentration; grooming behavior; integral to membrane; maternal aggressive behavior; maternal behavior; myotube differentiation; negative regulation of female receptivity; negative regulation of transmission of nerve impulse; penile erection; peptide hormone binding; plasma membrane; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cellular pH reduction; positive regulation of glutamate secretion; positive regulation of glycogen catabolic process; positive regulation of heart rate; positive regulation of prostaglandin biosynthetic process; positive regulation of renal sodium excretion; positive regulation of systemic arterial blood pressure; positive regulation of urine volume; positive regulation of vasoconstriction; regulation of corticotropin secretion; regulation of systemic arterial blood pressure by vasopressin; response to corticosterone stimulus; social behavior; sperm ejaculation; telencephalon development; vasopressin receptor activity IPR015076; IPR000276; IPR017452; IPR001817; IPR001224; Vasopressin V1a receptor (V1aR) (AVPR V1a) (Antidiuretic hormone receptor 1a) (Vascular/hepatic-type arginine vasopressin receptor) Avpr1a Rattus norvegicus (Rat) TR36085_c3_g1_i13 Q96P66 GP101_HUMAN 8.00E-06 GO:0004935; GO:0071875; GO:0016021; GO:0005886 adrenergic receptor activity; adrenergic receptor signaling pathway; integral to membrane; plasma membrane IPR002233; IPR000276; IPR017452; Probable G-protein coupled receptor 101 GPR101 Homo sapiens (Human) TR36085_c3_g1_i3 Q90252 MTR_BUFMA 2.00E-22 GO:0016021; GO:0004990; GO:0005886; GO:0005000 integral to membrane; oxytocin receptor activity; plasma membrane; vasopressin receptor activity IPR000276; IPR017452; IPR002062; IPR001817; Mesotocin receptor (MTR) Bufo marinus (Giant toad) (Cane toad) TR36085_c3_g1_i6 Q90252 MTR_BUFMA 2.00E-21 GO:0016021; GO:0004990; GO:0005886; GO:0005000 integral to membrane; oxytocin receptor activity; plasma membrane; vasopressin receptor activity IPR000276; IPR017452; IPR002062; IPR001817; Mesotocin receptor (MTR) Bufo marinus (Giant toad) (Cane toad) TR36085_c3_g1_i7 P30969 GNRHR_RAT 1.00E-13 GO:0097211; GO:0004968; GO:0016520; GO:0016021; GO:0008285; GO:0005886 cellular response to gonadotropin-releasing hormone; gonadotropin-releasing hormone receptor activity; growth hormone-releasing hormone receptor activity; integral to membrane; negative regulation of cell proliferation; plasma membrane IPR000276; IPR017452; IPR001658; IPR027982; Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R) Gnrhr Rattus norvegicus (Rat) TR36085_c3_g1_i8 Q868T3 CCAPR_DROME 2.00E-25 GO:0018990; GO:0005887; GO:0008188; GO:0005000 "ecdysis, chitin-based cuticle; integral to plasma membrane; neuropeptide receptor activity; vasopressin receptor activity" IPR000276; IPR017452; IPR001817; Cardioacceleratory peptide receptor CcapR CG6111 Drosophila melanogaster (Fruit fly) TR36086_c0_g2_i1 Q5RD73 DUS3_PONAB 8.00E-37 GO:0033549; GO:0005829; GO:0001772; GO:0070373; GO:0046329; GO:0050868; GO:0050860; GO:0005634; GO:0045931; GO:0004725; GO:0008138 MAP kinase phosphatase activity; cytosol; immunological synapse; negative regulation of ERK1 and ERK2 cascade; negative regulation of JNK cascade; negative regulation of T cell activation; negative regulation of T cell receptor signaling pathway; nucleus; positive regulation of mitotic cell cycle; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR020417; IPR020405; IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Vaccinia H1-related phosphatase) (VHR) DUSP3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36086_c0_g2_i2 Q9PW71 DUS4_CHICK 7.00E-14 GO:0017017; GO:0001706; GO:0005654; GO:0035335; GO:0004725 MAP kinase tyrosine/serine/threonine phosphatase activity; endoderm formation; nucleoplasm; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR000340; IPR020422; IPR024950; IPR008343; IPR001763; IPR000387; IPR016130; Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) DUSP4 MKP2 Gallus gallus (Chicken) TR36086_c0_g2_i3 Q6B8I0 MDSP_MOUSE 2.00E-30 GO:0005737; GO:0035335; GO:0004725; GO:0008138 cytoplasm; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR020417; IPR020405; IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Dual specificity protein phosphatase 13 isoform A (DUSP13A) (EC 3.1.3.16) (EC 3.1.3.48) (Muscle-restricted DSP) Dusp13 Dusp13a Mdsp Mus musculus (Mouse) TR36086_c0_g2_i4 P0C596 DUPD1_PIG 2.00E-26 GO:0005737; GO:0035335; GO:0004725; GO:0008138 cytoplasm; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR020417; IPR020405; IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Dual specificity phosphatase DUPD1 (EC 3.1.3.16) (EC 3.1.3.48) DUPD1 Sus scrofa (Pig) TR36087_c3_g1_i1 P13821 SANT_PLAFW 6.00E-15 GO:0020003 symbiont-containing vacuole IPR008825; S-antigen protein Plasmodium falciparum (isolate Wellcome) TR36088_c0_g1_i2 Q92406 NDUV1_ASPNG 0 GO:0051539; GO:0010181; GO:0051287; GO:0008137; GO:0046872; GO:0005743; GO:0070469 "4 iron, 4 sulfur cluster binding; FMN binding; NAD binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; mitochondrial inner membrane; respiratory chain" IPR001949; IPR019575; IPR011537; IPR011538; IPR019554; "NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-51kD) (CI-51kD)" NUO51 Aspergillus niger TR36088_c0_g1_i3 P25708 NDUV1_BOVIN 0 GO:0051539; GO:0010181; GO:0051287; GO:0008137; GO:0046872; GO:0005747 "4 iron, 4 sulfur cluster binding; FMN binding; NAD binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; mitochondrial respiratory chain complex I" IPR001949; IPR019575; IPR011537; IPR011538; IPR019554; "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-51kD) (CI-51kD) (NADH dehydrogenase flavoprotein 1) (NADH-ubiquinone oxidoreductase 51 kDa subunit)" NDUFV1 UQOR1 Bos taurus (Bovine) TR36089_c1_g1_i1 Q8CCN5 BCAS3_MOUSE 2.00E-118 GO:0071944; GO:0005737; GO:0005634 cell periphery; cytoplasm; nucleus IPR022175; IPR015943; IPR001680; IPR017986; Breast carcinoma-amplified sequence 3 homolog (K20D4) Bcas3 Mus musculus (Mouse) TR36091_c0_g1_i1 O13505 IPYR_PICPA 5.00E-106 GO:0005737; GO:0004427; GO:0000287; GO:0006796 cytoplasm; inorganic diphosphatase activity; magnesium ion binding; phosphate-containing compound metabolic process IPR008162; Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) IPP1 Komagataella pastoris (Yeast) (Pichia pastoris) TR36091_c0_g2_i2 O13505 IPYR_PICPA 5.00E-10 GO:0005737; GO:0004427; GO:0000287; GO:0006796 cytoplasm; inorganic diphosphatase activity; magnesium ion binding; phosphate-containing compound metabolic process IPR008162; Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) IPP1 Komagataella pastoris (Yeast) (Pichia pastoris) TR36092_c0_g1_i1 A6NK06 IRG1_HUMAN 5.00E-129 GO:0047547; GO:0047613; GO:0035458; GO:0071346; GO:0071347; GO:0071393; GO:0071356; GO:0007566; GO:0006954; GO:0005739; GO:0032088; GO:0050728; GO:0045824; GO:0034136; GO:0032480; GO:0002760; GO:2000379; GO:0019543; GO:0072573 2-methylcitrate dehydratase activity; aconitate decarboxylase activity; cellular response to interferon-beta; cellular response to interferon-gamma; cellular response to interleukin-1; cellular response to progesterone stimulus; cellular response to tumor necrosis factor; embryo implantation; inflammatory response; mitochondrion; negative regulation of NF-kappaB transcription factor activity; negative regulation of inflammatory response; negative regulation of innate immune response; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of type I interferon production; positive regulation of antimicrobial humoral response; positive regulation of reactive oxygen species metabolic process; propionate catabolic process; tolerance induction to lipopolysaccharide IPR005656; Cis-aconitate decarboxylase (CAD) (EC 4.1.1.6) (Aconitate decarboxylase) (Cis-aconitic acid decarboxylase) (Immune-responsive gene 1 protein) IRG1 Homo sapiens (Human) TR36093_c2_g1_i1 Q8WWP7 GIMA1_HUMAN 6.00E-09 GO:0030183; GO:0005525; GO:0000139; GO:0030217; GO:0005789; GO:0016021 B cell differentiation; GTP binding; Golgi membrane; T cell differentiation; endoplasmic reticulum membrane; integral to membrane IPR006703; IPR027417; GTPase IMAP family member 1 (Immunity-associated protein 1) (hIMAP1) GIMAP1 IMAP1 Homo sapiens (Human) TR36094_c3_g2_i3 Q9CR41 HYPK_MOUSE 1.00E-16 GO:0005737; GO:0005634 cytoplasm; nucleus Huntingtin-interacting protein K (Huntingtin yeast partner K) Hypk Mus musculus (Mouse) TR36094_c3_g2_i4 Q9CR41 HYPK_MOUSE 6.00E-16 GO:0005737; GO:0005634 cytoplasm; nucleus Huntingtin-interacting protein K (Huntingtin yeast partner K) Hypk Mus musculus (Mouse) TR36095_c2_g1_i1 Q6DRN3 NOC3L_DANRE 5.00E-127 GO:0007517; GO:0005730; GO:0005634; GO:0019216 muscle organ development; nucleolus; nucleus; regulation of lipid metabolic process IPR016024; IPR005612; IPR011501; IPR016903; Nucleolar complex protein 3 homolog (NOC3 protein homolog) (NOC3-like protein) (Nucleolar complex-associated protein 3-like protein) noc3l Danio rerio (Zebrafish) (Brachydanio rerio) TR36096_c1_g2_i1 Q9SKK0 EBF1_ARATH 1.00E-08 GO:0009873; GO:0010105; GO:0005634; GO:0016567; GO:0009723; GO:0006511 O49484; O24606; Q39255; Q9FHW7; P43291 ethylene mediated signaling pathway; negative regulation of ethylene mediated signaling pathway; nucleus; protein ubiquitination; response to ethylene stimulus; ubiquitin-dependent protein catabolic process IPR001810; IPR006553; Protein modification; protein ubiquitination. EIN3-binding F-box protein 1 (F-box/LRR-repeat protein 6) EBF1 FBL6 At2g25490 F13B15.15 Arabidopsis thaliana (Mouse-ear cress) TR36100_c2_g5_i1 Q9Y3D2 MSRB2_HUMAN 3.00E-51 GO:0003779; GO:0030041; GO:0005739; GO:0033743; GO:0030091; GO:0003700; GO:0008270 actin binding; actin filament polymerization; mitochondrion; peptide-methionine (R)-S-oxide reductase activity; protein repair; sequence-specific DNA binding transcription factor activity; zinc ion binding IPR002579; IPR011057; "Methionine-R-sulfoxide reductase B2, mitochondrial (MsrB2) (EC 1.8.4.-)" MSRB2 CBS-1 MSRB CGI-131 Homo sapiens (Human) TR36100_c2_g5_i2 P34436 YL56_CAEEL 4.00E-09 GO:0046872; GO:0033743 metal ion binding; peptide-methionine (R)-S-oxide reductase activity IPR002579; IPR011057; Uncharacterized protein F44E2.6 F44E2.6 Caenorhabditis elegans TR36100_c2_g5_i4 Q9Y3D2 MSRB2_HUMAN 2.00E-14 GO:0003779; GO:0030041; GO:0005739; GO:0033743; GO:0030091; GO:0003700; GO:0008270 actin binding; actin filament polymerization; mitochondrion; peptide-methionine (R)-S-oxide reductase activity; protein repair; sequence-specific DNA binding transcription factor activity; zinc ion binding IPR002579; IPR011057; "Methionine-R-sulfoxide reductase B2, mitochondrial (MsrB2) (EC 1.8.4.-)" MSRB2 CBS-1 MSRB CGI-131 Homo sapiens (Human) TR36101_c0_g1_i2 Q6PD74 AAGAB_HUMAN 6.00E-33 GO:0005737; GO:0005829; GO:0015031 cytoplasm; cytosol; protein transport IPR019341; Alpha- and gamma-adaptin-binding protein p34 AAGAB Homo sapiens (Human) TR36103_c0_g1_i2 Q5TFE4 NT5D1_HUMAN 2.00E-42 GO:0016787; GO:0046872 hydrolase activity; metal ion binding IPR023214; IPR008380; 5'-nucleotidase domain-containing protein 1 (EC 3.1.3.-) NT5DC1 NT5C2L1 LP2642 Homo sapiens (Human) TR36103_c0_g1_i3 Q54XC1 5NTC_DICDI 3.00E-12 GO:0008253; GO:0046872; GO:0006139; GO:0000166; GO:0009117; GO:0045335 5'-nucleotidase activity; metal ion binding; nucleobase-containing compound metabolic process; nucleotide binding; nucleotide metabolic process; phagocytic vesicle IPR023214; IPR008380; IPR016695; Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (Cytosolic 5'-nucleotidase II) nt5c2 DDB_G0279053 Dictyostelium discoideum (Slime mold) TR36103_c0_g3_i1 Q3UHB1 NT5D3_MOUSE 5.00E-07 GO:0005829; GO:0016787; GO:0046872; GO:0005739 cytosol; hydrolase activity; metal ion binding; mitochondrion IPR023214; IPR008380; IPR016695; 5'-nucleotidase domain-containing protein 3 (EC 3.1.3.-) (GRP94-neighboring nucleotidase) Nt5dc3 Gnn Mus musculus (Mouse) TR36108_c0_g1_i2 B5U6Y8 OXLA_ECHOC 2.00E-48 GO:0001716; GO:0006915; GO:0019835; GO:0042742; GO:0005576; GO:0044179 L-amino-acid oxidase activity; apoptotic process; cytolysis; defense response to bacterium; extracellular region; hemolysis in other organism IPR002937; L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) Echis ocellatus (Ocellated saw-scaled viper) TR36108_c0_g1_i3 O34363 YOBN_BACSU 3.00E-56 GO:0001716 L-amino-acid oxidase activity IPR002937; IPR001613; Putative L-amino-acid oxidase YobN (EC 1.4.3.2) yobN BSU19020 Bacillus subtilis (strain 168) TR36109_c0_g1_i2 Q9CY94 PSF3_MOUSE 1.00E-61 GO:0006260; GO:0005634 DNA replication; nucleus IPR021151; IPR010492; DNA replication complex GINS protein PSF3 (GINS complex subunit 3) Gins3 Psf3 Mus musculus (Mouse) TR36109_c0_g1_i3 Q08E12 PSF3_BOVIN 3.00E-58 GO:0006260; GO:0005634 DNA replication; nucleus IPR021151; IPR010492; DNA replication complex GINS protein PSF3 (GINS complex subunit 3) GINS3 PSF3 Bos taurus (Bovine) TR36111_c3_g1_i1 Q6DGZ0 CCD75_DANRE 3.00E-35 GO:0003676 nucleic acid binding IPR025239; IPR000467; G patch domain-containing protein 11 (Coiled-coil domain-containing protein 75) gpatch11 ccdc75 zgc:92714 Danio rerio (Zebrafish) (Brachydanio rerio) TR36111_c3_g1_i2 P18583 SON_HUMAN 2.00E-07 GO:0003677; GO:0003723; GO:0008380; GO:0000910; GO:0006397; GO:0000226; GO:0043066; GO:0016607; GO:0043484; GO:0051726 DNA binding; RNA binding; RNA splicing; cytokinesis; mRNA processing; microtubule cytoskeleton organization; negative regulation of apoptotic process; nuclear speck; regulation of RNA splicing; regulation of cell cycle IPR014720; IPR000467; IPR017986; Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) SON C21orf50 DBP5 KIAA1019 NREBP HSPC310 HSPC312 Homo sapiens (Human) TR36111_c3_g1_i3 Q6DF57 CCD75_XENTR 5.00E-32 GO:0003676 nucleic acid binding IPR025239; IPR000467; G patch domain-containing protein 11 (Coiled-coil domain-containing protein 75) gpatch11 ccdc75 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36112_c1_g1_i1 P0CB14 VM1K_CALRH 6.00E-12 GO:0005576; GO:0004222; GO:0006508; GO:0008270 extracellular region; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR001590; IPR002870; Snake venom metalloproteinase kistomin (SVMP) (EC 3.4.24.-) Calloselasma rhodostoma (Malayan pit viper) (Agkistrodon rhodostoma) TR36112_c2_g1_i1 Q13443 ADAM9_HUMAN 5.00E-67 GO:0051088; GO:0017124; GO:0000186; GO:0033631; GO:0007160; GO:0071222; GO:0005518; GO:0030574; GO:0005737; GO:0022617; GO:0005615; GO:0016021; GO:0005178; GO:0007229; GO:0031233; GO:0030216; GO:0043236; GO:0004222; GO:0042117; GO:0033630; GO:0051549; GO:0034241; GO:0051044; GO:0050714; GO:0005080; GO:0051592; GO:0051384; GO:0042542; GO:0010042; GO:0034612; GO:0007179; GO:0008270 Q9UI95; Q9UKS6; Q99962 PMA-inducible membrane protein ectodomain proteolysis; SH3 domain binding; activation of MAPKK activity; cell-cell adhesion mediated by integrin; cell-matrix adhesion; cellular response to lipopolysaccharide; collagen binding; collagen catabolic process; cytoplasm; extracellular matrix disassembly; extracellular space; integral to membrane; integrin binding; integrin-mediated signaling pathway; intrinsic to external side of plasma membrane; keratinocyte differentiation; laminin binding; metalloendopeptidase activity; monocyte activation; positive regulation of cell adhesion mediated by integrin; positive regulation of keratinocyte migration; positive regulation of macrophage fusion; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein secretion; protein kinase C binding; response to calcium ion; response to glucocorticoid stimulus; response to hydrogen peroxide; response to manganese ion; response to tumor necrosis factor; transforming growth factor beta receptor signaling pathway; zinc ion binding IPR006586; IPR001762; IPR018358; IPR000742; IPR013032; IPR024079; IPR001590; IPR002870; Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) ADAM9 KIAA0021 MCMP MDC9 MLTNG Homo sapiens (Human) TR36112_c2_g1_i2 Q6NVV9 ADAM5_HUMAN 7.00E-16 GO:0004222; GO:0006508; GO:0008270 metalloendopeptidase activity; proteolysis; zinc ion binding IPR006586; IPR001762; IPR000742; IPR013032; IPR002870; "Putative disintegrin and metalloproteinase domain-containing protein 5 (Putative transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II) (tMDC II)" ADAM5 ADAM5P TMDC2 Homo sapiens (Human) TR36112_c5_g1_i1 O35674 ADA19_MOUSE 4.00E-07 GO:0007507; GO:0016021; GO:0006509; GO:0004222; GO:0008270 heart development; integral to membrane; membrane protein ectodomain proteolysis; metalloendopeptidase activity; zinc ion binding IPR006586; IPR001762; IPR018358; IPR000742; IPR013032; IPR024079; IPR001590; IPR002870; Disintegrin and metalloproteinase domain-containing protein 19 (ADAM 19) (EC 3.4.24.-) (Meltrin-beta) Adam19 Mltnb Mus musculus (Mouse) TR36113_c1_g1_i1 Q8IXH7 NELFD_HUMAN 2.00E-150 GO:0032021; GO:0045892; GO:0050434; GO:0006368; GO:0016032 P10398; Q9H3P2 "NELF complex; negative regulation of transcription, DNA-dependent; positive regulation of viral transcription; transcription elongation from RNA polymerase II promoter; viral process" IPR006942; Negative elongation factor C/D (NELF-C/D) (TH1-like protein) NELFCD NELFD TH1 TH1L HSPC130 Homo sapiens (Human) TR36116_c0_g1_i1 Q3KR37 GRM1B_HUMAN 8.00E-66 GO:0016021 integral to membrane IPR004182; GRAM domain-containing protein 1B GRAMD1B KIAA1201 UNQ3032/PRO9834 Homo sapiens (Human) TR36116_c1_g1_i2 Q8CI52 GRM1C_MOUSE 1.00E-31 GO:0016021 integral to membrane GRAM domain-containing protein 1C Gramd1c Mus musculus (Mouse) TR36116_c1_g1_i3 Q3KR37 GRM1B_HUMAN 5.00E-56 GO:0016021 integral to membrane IPR004182; GRAM domain-containing protein 1B GRAMD1B KIAA1201 UNQ3032/PRO9834 Homo sapiens (Human) TR36116_c1_g1_i4 Q80TI0 GRM1B_MOUSE 4.00E-56 GO:0016021 integral to membrane IPR004182; GRAM domain-containing protein 1B Gramd1b Kiaa1201 Mus musculus (Mouse) TR36116_c1_g1_i5 Q8IYS0 GRM1C_HUMAN 5.00E-33 GO:0016021 integral to membrane IPR004182; GRAM domain-containing protein 1C GRAMD1C UNQ2543/PRO6095 Homo sapiens (Human) TR36117_c5_g3_i1 O70461 MOT3_RAT 7.00E-10 GO:0009925; GO:0016021; GO:0015355; GO:0015293 basal plasma membrane; integral to membrane; secondary active monocarboxylate transmembrane transporter activity; symporter activity IPR011701; IPR020846; IPR016196; IPR004743; Monocarboxylate transporter 3 (MCT 3) (Solute carrier family 16 member 8) Slc16a8 Mct3 Rattus norvegicus (Rat) TR36117_c5_g3_i2 Q7TM99 MOT9_MOUSE 6.00E-11 GO:0016021; GO:0005886; GO:0015293; GO:0046415 integral to membrane; plasma membrane; symporter activity; urate metabolic process IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) Slc16a9 Mct9 Mus musculus (Mouse) TR36119_c0_g2_i1 Q3UJP5 CH037_MOUSE 5.00E-38 GO:0005737 cytoplasm Protein C8orf37 homolog Mus musculus (Mouse) TR36119_c0_g2_i2 Q6AY71 CH037_RAT 7.00E-36 GO:0005737 cytoplasm Protein C8orf37 homolog Rattus norvegicus (Rat) TR36119_c0_g2_i3 Q3UJP5 CH037_MOUSE 6.00E-38 GO:0005737 cytoplasm Protein C8orf37 homolog Mus musculus (Mouse) TR3612_c0_g1_i1 P98157 LRP1_CHICK 7.00E-12 GO:0005509; GO:0005905; GO:0006897; GO:0016021 calcium ion binding; coated pit; endocytosis; integral to membrane IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) LRP1 Gallus gallus (Chicken) TR36120_c0_g1_i1 Q9VCY8 ADRL_DROME 1.00E-138 GO:0019395; GO:0042593; GO:0042562; GO:0009755; GO:0016021; GO:0032024; GO:0070328 fatty acid oxidation; glucose homeostasis; hormone binding; hormone-mediated signaling pathway; integral to membrane; positive regulation of insulin secretion; triglyceride homeostasis IPR004254; ADIPOR-like receptor CG5315 CG5315 Drosophila melanogaster (Fruit fly) TR36120_c0_g1_i2 A8WZU4 ADRL_CAEBR 2.00E-55 GO:0006631; GO:0016021 fatty acid metabolic process; integral to membrane IPR004254; IPR001610; Progestin and adipoQ receptor-like protein 1 paqr-1 CBG05420 Caenorhabditis briggsae TR36121_c0_g3_i1 Q2YDE7 ARCH_BOVIN 3.00E-63 IPR002804; IPR023572; Protein archease (Protein ZBTB8OS) ZBTB8OS ARCH Bos taurus (Bovine) TR36121_c0_g3_i4 Q2YDE7 ARCH_BOVIN 2.00E-63 IPR002804; IPR023572; Protein archease (Protein ZBTB8OS) ZBTB8OS ARCH Bos taurus (Bovine) TR36121_c0_g3_i6 Q9YFV2 ARCH_AERPE 3.00E-17 IPR002804; IPR022952; IPR023572; Protein archease APE_0148.1 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) TR36121_c0_g4_i4 Q03046 CEFD_NOCLA 1.00E-21 GO:0017000; GO:0045439; GO:0030170 antibiotic biosynthetic process; isopenicillin-N epimerase activity; pyridoxal phosphate binding IPR000192; IPR020578; IPR015424; IPR015421; IPR015422; Antibiotic biosynthesis; cephalosporin C biosynthesis. Isopenicillin N epimerase (EC 5.1.1.17) cefD Amycolatopsis lactamdurans (Nocardia lactamdurans) TR36124_c3_g2_i3 Q9CYC3 TM39A_MOUSE 6.00E-100 GO:0016021 integral to membrane IPR019397; Transmembrane protein 39A Tmem39a Mus musculus (Mouse) TR36124_c3_g2_i4 Q9CYC3 TM39A_MOUSE 3.00E-15 GO:0016021 integral to membrane IPR019397; Transmembrane protein 39A Tmem39a Mus musculus (Mouse) TR36127_c1_g3_i1 Q5T1Q4 S35F1_HUMAN 9.00E-48 GO:0016021; GO:0006810 integral to membrane; transport IPR009262; Solute carrier family 35 member F1 SLC35F1 C6orf169 Homo sapiens (Human) TR36129_c0_g1_i1 O13754 CNS1_SCHPO 5.00E-18 GO:0005829; GO:0031072; GO:0005634; GO:0043234; GO:0006457 cytosol; heat shock protein binding; nucleus; protein complex; protein folding IPR013026; IPR011990; IPR001440; Hsp70/Hsp90 co-chaperone cns1 cns1 SPAC17A2.04c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36129_c0_g1_i2 Q5R5X9 SMYD4_PONAB 7.00E-06 GO:0046872; GO:0008168 metal ion binding; methyltransferase activity IPR001214; IPR011990; IPR013105; IPR019734; IPR002893; SET and MYND domain-containing protein 4 (EC 2.1.1.-) SMYD4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36129_c0_g1_i3 O95801 TTC4_HUMAN 3.00E-80 IPR013026; IPR011990; IPR019734; Tetratricopeptide repeat protein 4 (TPR repeat protein 4) TTC4 My044 Homo sapiens (Human) TR36129_c0_g1_i4 Q54M20 TTC4_DICDI 1.00E-27 IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 4 homolog (TPR repeat protein 4 homolog) ttc4 DDB_G0286253 Dictyostelium discoideum (Slime mold) TR36130_c2_g1_i1 Q9K907 PRPE_BACHD 2.00E-09 GO:0005525; GO:0004081; GO:0016151 GTP binding; bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity; nickel cation binding IPR023937; IPR004843; IPR006186; "Bis(5'-nucleosyl)-tetraphosphatase PrpE [asymmetrical] (EC 3.6.1.17) (Ap4A hydrolase) (Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase) (Diadenosine tetraphosphatase)" prpE BH2845 Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) TR36130_c2_g2_i4 Q7W3V0 APAH_BORPA 1.00E-06 GO:0008803 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity IPR004617; IPR004843; "Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC 3.6.1.41) (Ap4A hydrolase) (Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase) (Diadenosine tetraphosphatase)" apaH BPP3927 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) TR36131_c0_g1_i2 B4MA12 WUHO_DROVI 8.00E-31 GO:0030154; GO:0001674; GO:0001673; GO:0007275; GO:0048477; GO:0007283; GO:0008033 cell differentiation; female germ cell nucleus; male germ cell nucleus; multicellular organismal development; oogenesis; spermatogenesis; tRNA processing IPR015943; IPR001680; IPR017986; tRNA modification; N(7)-methylguanine-tRNA biosynthesis. tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wuho wuho GJ15762 Drosophila virilis (Fruit fly) TR36131_c0_g2_i1 A4IGH4 WDR4_DANRE 2.00E-54 GO:0036265; GO:0005634; GO:0006400 RNA (guanine-N7)-methylation; nucleus; tRNA modification IPR015943; IPR001680; IPR017986; tRNA modification; N(7)-methylguanine-tRNA biosynthesis. tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wdr4 (WD repeat-containing protein 4) wdr4 si:ch211-140m22.6 Danio rerio (Zebrafish) (Brachydanio rerio) TR36132_c8_g1_i1 Q55EU6 ACT23_DICDI 4.00E-50 GO:0005524; GO:0015629; GO:0000902; GO:0017022; GO:0045335; GO:0005200 ATP binding; actin cytoskeleton; cell morphogenesis; myosin binding; phagocytic vesicle; structural constituent of cytoskeleton IPR004000; IPR020902; IPR004001; Putative actin-23 act23 DDB_G0268744 Dictyostelium discoideum (Slime mold) TR36132_c8_g4_i2 Q54E71 ARP5_DICDI 8.00E-06 GO:0006310; GO:0006281; GO:0031011; GO:0006355; GO:0006351 "DNA recombination; DNA repair; Ino80 complex; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR004000; IPR027664; Actin-related protein 5 (Actin-related protein E) arpE actr5 DDB_G0291728 Dictyostelium discoideum (Slime mold) TR36132_c8_g4_i7 P10984 ACT2_CAEEL 6.00E-67 GO:0005524; GO:0016887; GO:0030036; GO:0005884; GO:0005938; GO:0007108; GO:0009790; GO:0040011; GO:0007126; GO:0000281 "ATP binding; ATPase activity; actin cytoskeleton organization; actin filament; cell cortex; cytokinesis, initiation of separation; embryo development; locomotion; meiosis; mitotic cytokinesis" IPR004000; IPR020902; IPR004001; Actin-2 act-2 T04C12.5 Caenorhabditis elegans TR36132_c8_g6_i2 P42023 ACTZ_PNECA 3.00E-31 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; Actin-2 (Actin II) (Centractin-like protein) Pneumocystis carinii TR36132_c8_g7_i1 P10982 ACT1_ABSGL 1.00E-06 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; Actin-1 (Fragment) ACT1 Absidia glauca (Pin mould) TR36134_c2_g2_i2 A1CIF1 TRMB_ASPCL 4.00E-24 GO:0036265; GO:0005634; GO:0008176; GO:0000049 RNA (guanine-N7)-methylation; nucleus; tRNA (guanine-N7-)-methyltransferase activity; tRNA binding IPR003358; IPR025763; tRNA modification; N(7)-methylguanine-tRNA biosynthesis. tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (Transfer RNA methyltransferase 8) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase) trm8 ACLA_051280 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) TR36134_c2_g3_i1 Q5XJ57 TRMB_DANRE 2.00E-65 GO:0005634; GO:0008176; GO:0000049 nucleus; tRNA (guanine-N7-)-methyltransferase activity; tRNA binding IPR003358; IPR025763; tRNA modification; N(7)-methylguanine-tRNA biosynthesis. tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (Methyltransferase-like protein 1) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase) mettl1 zgc:103636 Danio rerio (Zebrafish) (Brachydanio rerio) TR36134_c2_g3_i2 A1CWA9 TRMB_NEOFI 6.00E-20 GO:0036265; GO:0005634; GO:0008176; GO:0000049 RNA (guanine-N7)-methylation; nucleus; tRNA (guanine-N7-)-methyltransferase activity; tRNA binding IPR003358; IPR025763; tRNA modification; N(7)-methylguanine-tRNA biosynthesis. tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (Transfer RNA methyltransferase 8) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase) trm8 NFIA_103990 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) TR36136_c4_g1_i2 O61366 GPRS_DROME 5.00E-19 IPR011705; IPR000210; IPR011333; IPR013069; Serine-enriched protein gprs CG18471 Drosophila melanogaster (Fruit fly) TR36136_c6_g1_i1 Q68EX9 CHID1_XENLA 9.00E-81 GO:0005975; GO:0006032; GO:0004568; GO:0005576; GO:0005764 carbohydrate metabolic process; chitin catabolic process; chitinase activity; extracellular region; lysosome IPR011583; IPR001223; IPR013781; IPR017853; Chitinase domain-containing protein 1 chid1 Xenopus laevis (African clawed frog) TR36136_c6_g1_i3 Q66IL0 CHID1_XENTR 4.00E-45 GO:0005975; GO:0006032; GO:0004568; GO:0005576; GO:0005764 carbohydrate metabolic process; chitin catabolic process; chitinase activity; extracellular region; lysosome IPR011583; IPR001223; IPR013781; IPR017853; Chitinase domain-containing protein 1 chid1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36137_c4_g2_i1 Q99728 BARD1_HUMAN 9.00E-14 GO:0070531; GO:0031436; GO:0006281; GO:0003723; GO:0007050; GO:0005737; GO:0019900; GO:0043066; GO:0031441; GO:0046826; GO:0043065; GO:0045732; GO:0085020; GO:0042325; GO:0006974; GO:0001894; GO:0004842; GO:0008270 P38398; Q12873; Q05048; P33240; Q9Y2X7; O95251; Q9P2H0; O95453; O14776 BRCA1-A complex; BRCA1-BARD1 complex; DNA repair; RNA binding; cell cycle arrest; cytoplasm; kinase binding; negative regulation of apoptotic process; negative regulation of mRNA 3'-end processing; negative regulation of protein export from nucleus; positive regulation of apoptotic process; positive regulation of protein catabolic process; protein K6-linked ubiquitination; regulation of phosphorylation; response to DNA damage stimulus; tissue homeostasis; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR001357; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. BRCA1-associated RING domain protein 1 (BARD-1) (EC 6.3.2.-) BARD1 Homo sapiens (Human) TR36137_c4_g2_i2 Q9CR42 ANKR1_MOUSE 3.00E-17 GO:0003677; GO:0031674; GO:0001105; GO:0055008; GO:0035690; GO:0071456; GO:0071347; GO:0071222; GO:0071260; GO:0071407; GO:0071560; GO:0071356; GO:0005829; GO:2000279; GO:0000122; GO:0005634; GO:0043517; GO:0043065; GO:0010976; GO:0050714; GO:0006357; GO:0035994; GO:0035914; GO:0003714; GO:0005667 "DNA binding; I band; RNA polymerase II transcription coactivator activity; cardiac muscle tissue morphogenesis; cellular response to drug; cellular response to hypoxia; cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to organic cyclic compound; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; cytosol; negative regulation of DNA biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of apoptotic process; positive regulation of neuron projection development; positive regulation of protein secretion; regulation of transcription from RNA polymerase II promoter; response to muscle stretch; skeletal muscle cell differentiation; transcription corepressor activity; transcription factor complex" IPR002110; IPR020683; Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) Ankrd1 Carp Mus musculus (Mouse) TR36137_c4_g2_i3 Q8BZ25 ANKK1_MOUSE 5.00E-35 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR001245; IPR008271; Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) Ankk1 Mus musculus (Mouse) TR36137_c5_g1_i1 Q3SX45 ASB2_BOVIN 1.00E-27 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 2 (ASB-2) ASB2 Bos taurus (Bovine) TR36137_c5_g1_i2 Q12955 ANK3_HUMAN 6.00E-43 GO:0043001; GO:0030315; GO:0007411; GO:0043194; GO:0007409; GO:0016323; GO:0045296; GO:0009986; GO:0043034; GO:0014704; GO:0044325; GO:0016328; GO:0005764; GO:0072660; GO:0071709; GO:0000281; GO:0033268; GO:0033270; GO:0010628; GO:1900827; GO:0045838; GO:2000651; GO:0010765; GO:0045211; GO:0030674; GO:0072661; GO:0019228; GO:0043266; GO:0007165; GO:0030507; GO:0014731; GO:0005200; GO:0050808 "Golgi to plasma membrane protein transport; T-tubule; axon guidance; axon initial segment; axonogenesis; basolateral plasma membrane; cadherin binding; cell surface; costamere; intercalated disc; ion channel binding; lateral plasma membrane; lysosome; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; node of Ranvier; paranode region of axon; positive regulation of gene expression; positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; postsynaptic membrane; protein binding, bridging; protein targeting to plasma membrane; regulation of action potential in neuron; regulation of potassium ion transport; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton; synapse organization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) TR36137_c5_g1_i3 Q8WXE0 CSKI2_HUMAN 1.00E-21 GO:0005737 cytoplasm IPR002110; IPR020683; IPR027001; IPR001660; IPR013761; IPR021129; IPR011511; IPR001452; Caskin-2 (CASK-interacting protein 2) CASKIN2 KIAA1139 Homo sapiens (Human) TR36137_c5_g1_i4 Q9NWX5 ASB6_HUMAN 1.00E-07 GO:0005737; GO:0035556; GO:0016567 cytoplasm; intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 6 (ASB-6) ASB6 Homo sapiens (Human) TR36137_c5_g1_i5 Q3SWY2 ILK_BOVIN 2.00E-16 GO:0005524; GO:0005925; GO:0030027; GO:0005886; GO:0004674; GO:0009966; GO:0030017 ATP binding; focal adhesion; lamellipodium; plasma membrane; protein serine/threonine kinase activity; regulation of signal transduction; sarcomere IPR002110; IPR020683; IPR016253; IPR011009; IPR000719; IPR001245; Integrin-linked protein kinase (EC 2.7.11.1) ILK Bos taurus (Bovine) TR36137_c5_g1_i6 Q54KH3 ANR39_DICDI 2.00E-18 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 39 homolog ankrd39 DDB_G0287345 Dictyostelium discoideum (Slime mold) TR36137_c5_g1_i7 Q12955 ANK3_HUMAN 1.00E-34 GO:0043001; GO:0030315; GO:0007411; GO:0043194; GO:0007409; GO:0016323; GO:0045296; GO:0009986; GO:0043034; GO:0014704; GO:0044325; GO:0016328; GO:0005764; GO:0072660; GO:0071709; GO:0000281; GO:0033268; GO:0033270; GO:0010628; GO:1900827; GO:0045838; GO:2000651; GO:0010765; GO:0045211; GO:0030674; GO:0072661; GO:0019228; GO:0043266; GO:0007165; GO:0030507; GO:0014731; GO:0005200; GO:0050808 "Golgi to plasma membrane protein transport; T-tubule; axon guidance; axon initial segment; axonogenesis; basolateral plasma membrane; cadherin binding; cell surface; costamere; intercalated disc; ion channel binding; lateral plasma membrane; lysosome; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; node of Ranvier; paranode region of axon; positive regulation of gene expression; positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; postsynaptic membrane; protein binding, bridging; protein targeting to plasma membrane; regulation of action potential in neuron; regulation of potassium ion transport; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton; synapse organization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) TR36138_c1_g1_i2 Q711G3 IAH1_RAT 9.00E-65 GO:0016788; GO:0016042 "hydrolase activity, acting on ester bonds; lipid catabolic process" IPR001087; IPR013831; Isoamyl acetate-hydrolyzing esterase 1 homolog (EC 3.1.-.-) (Hypertrophic agonist-responsive protein B64) Iah1 Harpb64 Rattus norvegicus (Rat) TR36141_c2_g1_i4 Q8CCC3 CL056_MOUSE 2.00E-61 IPR027878; Uncharacterized protein C12orf56 homolog Mus musculus (Mouse) TR36141_c2_g4_i1 Q13368 MPP3_HUMAN 2.00E-40 GO:0009986; GO:0004385; GO:0005887; GO:0007165 cell surface; guanylate kinase activity; integral to plasma membrane; signal transduction IPR008145; IPR008144; IPR020590; IPR004172; IPR014775; IPR027417; IPR001478; IPR011511; IPR001452; MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3) MPP3 DLG3 Homo sapiens (Human) TR36141_c2_g4_i10 Q9QYH1 MPP4_RAT 5.00E-29 GO:0005737 cytoplasm IPR008145; IPR008144; IPR020590; IPR027417; IPR001478; IPR001452; MAGUK p55 subfamily member 4 (Discs large homolog 6) (rDLG6) Mpp4 Dlg6 Rattus norvegicus (Rat) TR36141_c2_g4_i11 Q6DEH3 KC2D1_DANRE 9.00E-41 GO:0005524; GO:0004683 ATP binding; calmodulin-dependent protein kinase activity IPR020636; IPR013543; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium/calmodulin-dependent protein kinase type II delta 1 chain (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase type II delta-B chain) (CaM kinase II subunit delta-B) (CaM-kinase II delta-B chain) (CaMK-II subunit delta-B) camk2d1 camk2db zgc:101001 zgc:173815 Danio rerio (Zebrafish) (Brachydanio rerio) TR36141_c2_g4_i12 Q62915 CSKP_RAT 4.00E-110 GO:0005524; GO:0005516; GO:0004683; GO:0060170; GO:0005829; GO:0030425; GO:0006886; GO:0005634; GO:0042734; GO:0008022; GO:0043234; GO:0006461; GO:0003713 O94868 ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; cilium membrane; cytosol; dendrite; intracellular protein transport; nucleus; presynaptic membrane; protein C-terminus binding; protein complex; protein complex assembly; transcription coactivator activity IPR008145; IPR008144; IPR020590; IPR011009; IPR004172; IPR014775; IPR027417; IPR001478; IPR000719; IPR002290; IPR011511; IPR001452; Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) Cask Rattus norvegicus (Rat) TR36141_c2_g4_i4 O70589 CSKP_MOUSE 0 GO:0005524; GO:0016323; GO:0070509; GO:0005911; GO:0005829; GO:0042043; GO:0005634; GO:0090280; GO:0045944; GO:0004674; GO:0045202 ATP binding; basolateral plasma membrane; calcium ion import; cell-cell junction; cytosol; neurexin family protein binding; nucleus; positive regulation of calcium ion import; positive regulation of transcription from RNA polymerase II promoter; protein serine/threonine kinase activity; synapse IPR008145; IPR008144; IPR020590; IPR011009; IPR004172; IPR014775; IPR027417; IPR001478; IPR000719; IPR002290; IPR011511; IPR001452; Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) Cask Mus musculus (Mouse) TR36141_c2_g4_i5 O14936 CSKP_HUMAN 0 GO:0005524; GO:0015629; GO:0005604; GO:0016323; GO:0070509; GO:0007155; GO:0005911; GO:0060170; GO:0005737; GO:0005829; GO:0030198; GO:0004385; GO:0001953; GO:0090288; GO:0010839; GO:0061045; GO:0005652; GO:0016363; GO:0005730; GO:0090280; GO:0045944; GO:0042734; GO:0004674 Q12929; P41134; O14910; Q63373; Q9Y2J0; P34741 ATP binding; actin cytoskeleton; basement membrane; basolateral plasma membrane; calcium ion import; cell adhesion; cell-cell junction; cilium membrane; cytoplasm; cytosol; extracellular matrix organization; guanylate kinase activity; negative regulation of cell-matrix adhesion; negative regulation of cellular response to growth factor stimulus; negative regulation of keratinocyte proliferation; negative regulation of wound healing; nuclear lamina; nuclear matrix; nucleolus; positive regulation of calcium ion import; positive regulation of transcription from RNA polymerase II promoter; presynaptic membrane; protein serine/threonine kinase activity IPR008145; IPR008144; IPR020590; IPR011009; IPR004172; IPR014775; IPR027417; IPR001478; IPR000719; IPR002290; IPR011511; IPR001452; Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) CASK LIN2 Homo sapiens (Human) TR36141_c2_g4_i6 Q62915 CSKP_RAT 0 GO:0005524; GO:0005516; GO:0004683; GO:0060170; GO:0005829; GO:0030425; GO:0006886; GO:0005634; GO:0042734; GO:0008022; GO:0043234; GO:0006461; GO:0003713 O94868 ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; cilium membrane; cytosol; dendrite; intracellular protein transport; nucleus; presynaptic membrane; protein C-terminus binding; protein complex; protein complex assembly; transcription coactivator activity IPR008145; IPR008144; IPR020590; IPR011009; IPR004172; IPR014775; IPR027417; IPR001478; IPR000719; IPR002290; IPR011511; IPR001452; Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) Cask Rattus norvegicus (Rat) TR36142_c0_g1_i2 Q9R088 KITM_MOUSE 3.00E-60 GO:0005524; GO:0009262; GO:0006264; GO:0005743; GO:0016773; GO:0004797 "ATP binding; deoxyribonucleotide metabolic process; mitochondrial DNA replication; mitochondrial inner membrane; phosphotransferase activity, alcohol group as acceptor; thymidine kinase activity" IPR002624; IPR027417; "Thymidine kinase 2, mitochondrial (EC 2.7.1.21) (Mt-TK)" Tk2 Mus musculus (Mouse) TR36143_c0_g2_i1 Q62981 ZN260_RAT 1.00E-43 GO:0003677; GO:0046872; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 260 (Zfp-260) (Pancreas-only zinc finger protein 1) (POZF-1) Znf260 Pex1 Zfp260 Rattus norvegicus (Rat) TR36143_c0_g2_i2 Q6P3V2 Z585A_HUMAN 3.00E-43 GO:0046872; GO:0003676; GO:0005634; GO:0006355; GO:0006351 "metal ion binding; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 585A ZNF585A Homo sapiens (Human) TR36143_c0_g2_i3 Q62981 ZN260_RAT 1.00E-43 GO:0003677; GO:0046872; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 260 (Zfp-260) (Pancreas-only zinc finger protein 1) (POZF-1) Znf260 Pex1 Zfp260 Rattus norvegicus (Rat) TR36144_c0_g1_i1 Q96EX3 WDR34_HUMAN 9.00E-24 GO:0005737 cytoplasm IPR015943; IPR001680; IPR017986; WD repeat-containing protein 34 WDR34 Homo sapiens (Human) TR36144_c0_g1_i4 Q16959 DYI2_ANTCR 0 GO:0035085; GO:0030286; GO:0005874; GO:0003774 cilium axoneme; dynein complex; microtubule; motor activity IPR015943; IPR001680; IPR017986; "Dynein intermediate chain 2, ciliary" Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR36146_c1_g1_i1 Q14517 FAT1_HUMAN 7.00E-07 GO:0007015; GO:0009653; GO:0005509; GO:0016477; GO:0016337; GO:0005911; GO:0007267; GO:0007163; GO:0030175; GO:0007156; GO:0005887; GO:0030027; GO:0005634; GO:0048471 Q8N8S7; Q9NSC5; Q99JP6 actin filament organization; anatomical structure morphogenesis; calcium ion binding; cell migration; cell-cell adhesion; cell-cell junction; cell-cell signaling; establishment or maintenance of cell polarity; filopodium; homophilic cell adhesion; integral to plasma membrane; lamellipodium; nucleus; perinuclear region of cytoplasm IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) TR36146_c3_g1_i1 Q60847 COCA1_MOUSE 2.00E-14 GO:0007155; GO:0005581; GO:0005615; GO:0070062 cell adhesion; collagen; extracellular space; extracellular vesicular exosome IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain Col12a1 Mus musculus (Mouse) TR36146_c3_g1_i2 Q62935 VWF_RAT 3.00E-15 GO:0007155; GO:0031012; GO:0030168; GO:0005578; GO:0042246 cell adhesion; extracellular matrix; platelet activation; proteinaceous extracellular matrix; tissue regeneration IPR002035; von Willebrand factor (vWF) (Fragment) Vwf Rattus norvegicus (Rat) TR36146_c3_g1_i3 P0C6B8 SVEP1_RAT 5.00E-08 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) TR36146_c3_g1_i4 O42163 COCH_CHICK 2.00E-07 GO:0005576; GO:0008360; GO:0007605 extracellular region; regulation of cell shape; sensory perception of sound IPR004043; IPR002035; Cochlin (COCH-5B2) COCH COCH5B2 Gallus gallus (Chicken) TR36146_c3_g1_i5 P04275 VWF_HUMAN 5.00E-10 GO:0033093; GO:0007597; GO:0031589; GO:0051087; GO:0005518; GO:0005783; GO:0009897; GO:0031012; GO:0005576; GO:0001948; GO:0019865; GO:0001889; GO:0001890; GO:0030168; GO:0031093; GO:0002576; GO:0002020; GO:0042803; GO:0051260; GO:0005578 Itself; Q76LX8; P07359; Q96CV9 "Weibel-Palade body; blood coagulation, intrinsic pathway; cell-substrate adhesion; chaperone binding; collagen binding; endoplasmic reticulum; external side of plasma membrane; extracellular matrix; extracellular region; glycoprotein binding; immunoglobulin binding; liver development; placenta development; platelet activation; platelet alpha granule lumen; platelet degranulation; protease binding; protein homodimerization activity; protein homooligomerization; proteinaceous extracellular matrix" IPR006207; IPR002919; IPR014853; IPR012011; IPR002035; IPR001007; IPR001846; von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)] VWF F8VWF Homo sapiens (Human) TR36146_c3_g1_i7 Q8NFW1 COMA1_HUMAN 4.00E-12 GO:0005581; GO:0005788; GO:0030198; GO:0005576 collagen; endoplasmic reticulum lumen; extracellular matrix organization; extracellular region IPR008160; IPR008985; IPR001791; IPR002035; Collagen alpha-1(XXII) chain COL22A1 Homo sapiens (Human) TR36147_c0_g1_i1 Q9H583 HEAT1_HUMAN 1.00E-44 GO:0005739; GO:0005730; GO:0006364; GO:0030529 Q76353 mitochondrion; nucleolus; rRNA processing; ribonucleoprotein complex IPR011989; IPR016024; IPR012954; IPR022125; "HEAT repeat-containing protein 1 (Protein BAP28) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed]" HEATR1 BAP28 Homo sapiens (Human) TR36147_c0_g2_i1 Q9VM75 HEAT1_DROME 3.00E-14 GO:0022008; GO:0005730; GO:0006364; GO:0030529 neurogenesis; nucleolus; rRNA processing; ribonucleoprotein complex IPR011989; IPR016024; IPR012954; IPR022125; HEAT repeat-containing protein 1 homolog l(2)k09022 CG10805 Drosophila melanogaster (Fruit fly) TR36147_c1_g1_i1 Q7SY48 HEAT1_DANRE 2.00E-24 GO:0000462; GO:0043066; GO:0005730; GO:0043487; GO:0030529 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); negative regulation of apoptotic process; nucleolus; regulation of RNA stability; ribonucleoprotein complex" IPR011989; IPR016024; IPR012954; IPR022125; HEAT repeat-containing protein 1 (Protein BAP28) heatr1 zgc:63510 Danio rerio (Zebrafish) (Brachydanio rerio) TR36148_c0_g1_i3 P41900 T2FB_DROME 6.00E-78 GO:0005524; GO:0008026; GO:0003677; GO:0032968; GO:0045944; GO:0060261; GO:0005674; GO:0006367 ATP binding; ATP-dependent helicase activity; DNA binding; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription initiation from RNA polymerase II promoter; transcription factor TFIIF complex; transcription initiation from RNA polymerase II promoter IPR016640; IPR003196; IPR011039; IPR011991; General transcription factor IIF subunit 2 (EC 3.6.4.12) (ATP-dependent helicase TfIIF-beta) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) TfIIFbeta TFIIF30 CG6538 Drosophila melanogaster (Fruit fly) TR36149_c0_g1_i1 Q9U6M0 ECSIT_DROME 2.00E-66 GO:0045087; GO:0005739; GO:0005634; GO:0016651; GO:0051341 "innate immune response; mitochondrion; nucleus; oxidoreductase activity, acting on NAD(P)H; regulation of oxidoreductase activity" IPR010418; "Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial" ECSIT CG10610 Drosophila melanogaster (Fruit fly) TR36150_c1_g3_i1 P51945 CCNG1_MOUSE 4.00E-19 GO:0007420; GO:0051301; GO:0016049; GO:0030425; GO:0007067; GO:0007095; GO:0043066; GO:0043025; GO:0005634; GO:0048471; GO:0010243; GO:0006949 brain development; cell division; cell growth; dendrite; mitosis; mitotic G2 DNA damage checkpoint; negative regulation of apoptotic process; neuronal cell body; nucleus; perinuclear region of cytoplasm; response to organonitrogen compound; syncytium formation IPR013763; IPR006671; Cyclin-G1 (Cyclin-G) Ccng1 Ccng Mus musculus (Mouse) TR36151_c0_g2_i1 P0C599 DUPD1_TAKRU 2.00E-45 GO:0005737; GO:0035335; GO:0004725; GO:0008138 cytoplasm; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR020417; IPR020405; IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Dual specificity phosphatase DUPD1 (EC 3.1.3.16) (EC 3.1.3.48) dupd1 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR36152_c0_g1_i1 Q9US13 RPN9_SCHPO 2.00E-70 GO:0005634; GO:0043161; GO:0008541; GO:0007346 "nucleus; proteasomal ubiquitin-dependent protein catabolic process; proteasome regulatory particle, lid subcomplex; regulation of mitotic cell cycle" IPR000717; Probable 26S proteasome regulatory subunit rpn9 rpn9 SPAC607.05 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36152_c0_g1_i2 Q04062 RPN9_YEAST 4.00E-48 GO:0005634; GO:0043248; GO:0008541; GO:0034515; GO:0005198; GO:0006511 P43588; Q12250; Q12377; Q08723 "nucleus; proteasome assembly; proteasome regulatory particle, lid subcomplex; proteasome storage granule; structural molecule activity; ubiquitin-dependent protein catabolic process" IPR000717; IPR011991; 26S proteasome regulatory subunit RPN9 (Proteasome non-ATPase subunit 7) RPN9 NAS7 YDR427W D9461.14 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR36152_c0_g1_i3 P84169 PSD13_CHICK 1.00E-158 GO:0022624 proteasome accessory complex IPR000717; 26S proteasome non-ATPase regulatory subunit 13 (26S proteasome regulatory subunit RPN9) (26S proteasome regulatory subunit S11) (26S proteasome regulatory subunit p40.5) PSMD13 Gallus gallus (Chicken) TR36153_c6_g2_i1 Q6GND3 JMD6A_XENLA 3.00E-163 GO:0008380; GO:0030154; GO:0033746; GO:0033749; GO:0006397; GO:0046872; GO:0005730; GO:0005654; GO:0070815; GO:0018395; GO:0048024; GO:0006355; GO:0003727; GO:0002040; GO:0006351 "RNA splicing; cell differentiation; histone demethylase activity (H3-R2 specific); histone demethylase activity (H4-R3 specific); mRNA processing; metal ion binding; nucleolus; nucleoplasm; peptidyl-lysine 5-dioxygenase activity; peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine; regulation of mRNA splicing, via spliceosome; regulation of transcription, DNA-dependent; single-stranded RNA binding; sprouting angiogenesis; transcription, DNA-dependent" IPR003347; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6-A (EC 1.14.11.-) (Histone arginine demethylase JMJD6-A) (JmjC domain-containing protein 6-A) (Jumonji domain-containing protein 6-A) (Lysyl-hydroxylase JMJD6-A) (Peptide-lysine 5-dioxygenase JMJD6-A) (Phosphatidylserine receptor-A) (Protein PTDSR-A) jmjd6-a ptdsr-a Xenopus laevis (African clawed frog) TR36154_c0_g2_i1 Q8WUQ7 CATIN_HUMAN 2.00E-119 GO:0071013; GO:0071347; GO:0071222; GO:0071356; GO:0045087; GO:0000398; GO:0007275; GO:0032088; GO:0032688; GO:0032717; GO:0031665; GO:0001933; GO:0034122; GO:0032720; GO:0060339 "catalytic step 2 spliceosome; cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to tumor necrosis factor; innate immune response; mRNA splicing, via spliceosome; multicellular organismal development; negative regulation of NF-kappaB transcription factor activity; negative regulation of interferon-beta production; negative regulation of interleukin-8 production; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of protein phosphorylation; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production; negative regulation of type I interferon-mediated signaling pathway" IPR019134; IPR018816; Cactin (Renal carcinoma antigen NY-REN-24) CACTIN C19orf29 Homo sapiens (Human) TR36155_c4_g1_i3 Q95K40 CCD83_MACFA 2.00E-25 IPR026702; Coiled-coil domain-containing protein 83 CCDC83 QtsA-10152 QtsA-19320 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR36157_c4_g3_i1 P45745 DHBF_BACSU 9.00E-07 GO:0009058; GO:0016788; GO:0016874; GO:0031177 "biosynthetic process; hydrolase activity, acting on ester bonds; ligase activity; phosphopantetheine binding" IPR010071; IPR009081; IPR025110; IPR020845; IPR000873; IPR001242; IPR020806; IPR001031; Siderophore biosynthesis; bacillibactin biosynthesis. Dimodular nonribosomal peptide synthase dhbF BSU31960 Bacillus subtilis (strain 168) TR36157_c4_g3_i3 O14975 S27A2_HUMAN 1.00E-125 GO:0005524; GO:0006699; GO:0005788; GO:0001561; GO:0006635; GO:0015245; GO:0030176; GO:0005779; GO:0044539; GO:0004467; GO:0097089; GO:0005739; GO:0050197; GO:0070251; GO:0042760; GO:0031957 ATP binding; bile acid biosynthetic process; endoplasmic reticulum lumen; fatty acid alpha-oxidation; fatty acid beta-oxidation; fatty acid transporter activity; integral to endoplasmic reticulum membrane; integral to peroxisomal membrane; long-chain fatty acid import; long-chain fatty acid-CoA ligase activity; methyl-branched fatty acid metabolic process; mitochondrion; phytanate-CoA ligase activity; pristanate-CoA ligase activity; very long-chain fatty acid catabolic process; very long-chain fatty acid-CoA ligase activity IPR025110; IPR020845; IPR000873; "Very long-chain acyl-CoA synthetase (VLACS) (VLCS) (EC 6.2.1.-) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 2) (THCA-CoA ligase) (Very long-chain-fatty-acid-CoA ligase)" SLC27A2 ACSVL1 FACVL1 FATP2 VLACS Homo sapiens (Human) TR36157_c4_g3_i5 O14975 S27A2_HUMAN 3.00E-125 GO:0005524; GO:0006699; GO:0005788; GO:0001561; GO:0006635; GO:0015245; GO:0030176; GO:0005779; GO:0044539; GO:0004467; GO:0097089; GO:0005739; GO:0050197; GO:0070251; GO:0042760; GO:0031957 ATP binding; bile acid biosynthetic process; endoplasmic reticulum lumen; fatty acid alpha-oxidation; fatty acid beta-oxidation; fatty acid transporter activity; integral to endoplasmic reticulum membrane; integral to peroxisomal membrane; long-chain fatty acid import; long-chain fatty acid-CoA ligase activity; methyl-branched fatty acid metabolic process; mitochondrion; phytanate-CoA ligase activity; pristanate-CoA ligase activity; very long-chain fatty acid catabolic process; very long-chain fatty acid-CoA ligase activity IPR025110; IPR020845; IPR000873; "Very long-chain acyl-CoA synthetase (VLACS) (VLCS) (EC 6.2.1.-) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 2) (THCA-CoA ligase) (Very long-chain-fatty-acid-CoA ligase)" SLC27A2 ACSVL1 FACVL1 FATP2 VLACS Homo sapiens (Human) TR36157_c7_g1_i1 Q11082 YT66_CAEEL 2.00E-06 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR000276; IPR017452; Probable G-protein coupled receptor B0563.6 B0563.6 Caenorhabditis elegans TR36159_c3_g3_i1 Q868T3 CCAPR_DROME 3.00E-81 GO:0018990; GO:0005887; GO:0008188; GO:0005000 "ecdysis, chitin-based cuticle; integral to plasma membrane; neuropeptide receptor activity; vasopressin receptor activity" IPR000276; IPR017452; IPR001817; Cardioacceleratory peptide receptor CcapR CG6111 Drosophila melanogaster (Fruit fly) TR36159_c3_g3_i2 Q8BZP8 NPSR1_MOUSE 9.00E-55 GO:0016021; GO:0008188; GO:0007218; GO:0005886; GO:0005000 integral to membrane; neuropeptide receptor activity; neuropeptide signaling pathway; plasma membrane; vasopressin receptor activity IPR000276; IPR017452; IPR027294; IPR001817; Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) Npsr1 Gpr154 Pgr14 Mus musculus (Mouse) TR3616_c0_g1_i1 Q8I7P9 POL5_DROME 1.00E-12 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0090305; GO:0005634; GO:0008233; GO:0006508; GO:0006313 "DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus; peptidase activity; proteolysis; transposition, DNA-mediated" IPR001584; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon opus [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR36161_c3_g1_i4 Q8CG46 SMC5_MOUSE 2.00E-87 GO:0005524; GO:0016605; GO:0030915; GO:0051301; GO:0090398; GO:0000781; GO:0000724; GO:0007067; GO:0034184; GO:0045842; GO:0000722 "ATP binding; PML body; Smc5-Smc6 complex; cell division; cellular senescence; chromosome, telomeric region; double-strand break repair via homologous recombination; mitosis; positive regulation of maintenance of mitotic sister chromatid cohesion; positive regulation of mitotic metaphase/anaphase transition; telomere maintenance via recombination" IPR027417; IPR003395; IPR027131; Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (mSMC5) (Protein expressed in male leptotene and zygotene spermatocytes 453) (MLZ-453) Smc5 Kiaa0594 Smc5l1 Mus musculus (Mouse) TR36161_c3_g1_i6 Q8CG46 SMC5_MOUSE 4.00E-88 GO:0005524; GO:0016605; GO:0030915; GO:0051301; GO:0090398; GO:0000781; GO:0000724; GO:0007067; GO:0034184; GO:0045842; GO:0000722 "ATP binding; PML body; Smc5-Smc6 complex; cell division; cellular senescence; chromosome, telomeric region; double-strand break repair via homologous recombination; mitosis; positive regulation of maintenance of mitotic sister chromatid cohesion; positive regulation of mitotic metaphase/anaphase transition; telomere maintenance via recombination" IPR027417; IPR003395; IPR027131; Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (mSMC5) (Protein expressed in male leptotene and zygotene spermatocytes 453) (MLZ-453) Smc5 Kiaa0594 Smc5l1 Mus musculus (Mouse) TR36162_c0_g1_i1 P10632 CP2C8_HUMAN 4.00E-108 GO:0070330; GO:0034875; GO:0005789; GO:0019373; GO:0042738; GO:0020037; GO:0005506; GO:0004497; GO:0097267; GO:0070989; GO:0006805 aromatase activity; caffeine oxidase activity; endoplasmic reticulum membrane; epoxygenase P450 pathway; exogenous drug catabolic process; heme binding; iron ion binding; monooxygenase activity; omega-hydroxylase P450 pathway; oxidative demethylation; xenobiotic metabolic process IPR001128; IPR017972; IPR002401; Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase) CYP2C8 Homo sapiens (Human) TR36164_c0_g1_i2 P13623 NFIX_MESAU 4.00E-101 GO:0003677; GO:0006260; GO:0005634; GO:0003700; GO:0006351 "DNA binding; DNA replication; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000647; IPR020604; IPR019739; IPR019548; IPR003619; Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) NFIX Mesocricetus auratus (Golden hamster) TR36164_c0_g1_i3 Q12857 NFIA_HUMAN 4.00E-100 GO:0003677; GO:0006260; GO:0030054; GO:0005634; GO:0045944; GO:0014070; GO:0003700; GO:0006351; GO:0019079 "DNA binding; DNA replication; cell junction; nucleus; positive regulation of transcription from RNA polymerase II promoter; response to organic cyclic compound; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; viral genome replication" IPR000647; IPR020604; IPR019739; IPR019548; IPR003619; Nuclear factor 1 A-type (NF1-A) (Nuclear factor 1/A) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/A) (NF-I/A) (NFI-A) (TGGCA-binding protein) NFIA KIAA1439 Homo sapiens (Human) TR36164_c0_g1_i4 P13623 NFIX_MESAU 9.00E-102 GO:0003677; GO:0006260; GO:0005634; GO:0003700; GO:0006351 "DNA binding; DNA replication; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000647; IPR020604; IPR019739; IPR019548; IPR003619; Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) NFIX Mesocricetus auratus (Golden hamster) TR36164_c0_g1_i5 P13623 NFIX_MESAU 9.00E-102 GO:0003677; GO:0006260; GO:0005634; GO:0003700; GO:0006351 "DNA binding; DNA replication; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000647; IPR020604; IPR019739; IPR019548; IPR003619; Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) NFIX Mesocricetus auratus (Golden hamster) TR36164_c0_g1_i6 Q12857 NFIA_HUMAN 4.00E-100 GO:0003677; GO:0006260; GO:0030054; GO:0005634; GO:0045944; GO:0014070; GO:0003700; GO:0006351; GO:0019079 "DNA binding; DNA replication; cell junction; nucleus; positive regulation of transcription from RNA polymerase II promoter; response to organic cyclic compound; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; viral genome replication" IPR000647; IPR020604; IPR019739; IPR019548; IPR003619; Nuclear factor 1 A-type (NF1-A) (Nuclear factor 1/A) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/A) (NF-I/A) (NFI-A) (TGGCA-binding protein) NFIA KIAA1439 Homo sapiens (Human) TR36164_c0_g1_i8 P13623 NFIX_MESAU 9.00E-102 GO:0003677; GO:0006260; GO:0005634; GO:0003700; GO:0006351 "DNA binding; DNA replication; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000647; IPR020604; IPR019739; IPR019548; IPR003619; Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) NFIX Mesocricetus auratus (Golden hamster) TR36166_c0_g1_i1 Q9QYL8 LYPA2_RAT 4.00E-66 GO:0005737; GO:0006631; GO:0016787 cytoplasm; fatty acid metabolic process; hydrolase activity IPR003140; Acyl-protein thioesterase 2 (APT-2) (EC 3.1.2.-) (Lysophospholipase 2) (Lysophospholipase II) (LPL-II) (LysoPLA II) Lypla2 Rattus norvegicus (Rat) TR36167_c0_g2_i1 Q8BMI3 GGA3_MOUSE 6.00E-78 GO:0005794; GO:0030131; GO:0010008; GO:0006886; GO:0045732; GO:0005802; GO:0016192 Golgi apparatus; clathrin adaptor complex; endosome membrane; intracellular protein transport; positive regulation of protein catabolic process; trans-Golgi network; vesicle-mediated transport IPR008152; IPR008153; IPR013041; IPR008942; IPR004152; IPR027422; IPR002014; IPR018205; "ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3)" Gga3 Kiaa0154 Mus musculus (Mouse) TR36167_c0_g2_i2 Q8BMI3 GGA3_MOUSE 9.00E-81 GO:0005794; GO:0030131; GO:0010008; GO:0006886; GO:0045732; GO:0005802; GO:0016192 Golgi apparatus; clathrin adaptor complex; endosome membrane; intracellular protein transport; positive regulation of protein catabolic process; trans-Golgi network; vesicle-mediated transport IPR008152; IPR008153; IPR013041; IPR008942; IPR004152; IPR027422; IPR002014; IPR018205; "ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3)" Gga3 Kiaa0154 Mus musculus (Mouse) TR36168_c4_g2_i2 Q27294 CAZ_DROME 8.00E-26 GO:0008344; GO:0071013; GO:0048749; GO:0008345; GO:0003729; GO:0000398; GO:0005654; GO:0000166; GO:0008270 "adult locomotory behavior; catalytic step 2 spliceosome; compound eye development; larval locomotory behavior; mRNA binding; mRNA splicing, via spliceosome; nucleoplasm; nucleotide binding; zinc ion binding" IPR012677; IPR000504; IPR001876; RNA-binding protein cabeza (P19) (Sarcoma-associated RNA-binding fly homolog) caz SARFH CG3606 Drosophila melanogaster (Fruit fly) TR36168_c4_g2_i5 Q27294 CAZ_DROME 5.00E-27 GO:0008344; GO:0071013; GO:0048749; GO:0008345; GO:0003729; GO:0000398; GO:0005654; GO:0000166; GO:0008270 "adult locomotory behavior; catalytic step 2 spliceosome; compound eye development; larval locomotory behavior; mRNA binding; mRNA splicing, via spliceosome; nucleoplasm; nucleotide binding; zinc ion binding" IPR012677; IPR000504; IPR001876; RNA-binding protein cabeza (P19) (Sarcoma-associated RNA-binding fly homolog) caz SARFH CG3606 Drosophila melanogaster (Fruit fly) TR36169_c1_g1_i1 P10567 MYSP_CAEEL 3.00E-50 GO:0040011; GO:0003774; GO:0030016; GO:0032982; GO:0051493; GO:0030241 Q966M3; Q9Y048; Q9TZ38; Q22534 locomotion; motor activity; myofibril; myosin filament; regulation of cytoskeleton organization; skeletal muscle myosin thick filament assembly IPR002928; Paramyosin (Uncoordinated protein 15) unc-15 F07A5.7 Caenorhabditis elegans TR36169_c3_g1_i1 P24733 MYS_AEQIR 1.00E-130 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR015650; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, striated muscle" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR36169_c6_g1_i2 Q92614 MY18A_HUMAN 6.00E-10 GO:0043531; GO:0005524; GO:0003677; GO:0006259; GO:0007030; GO:0048194; GO:0051015; GO:0042641; GO:0031032; GO:0016477; GO:0005793; GO:0003774; GO:0016459; GO:0043066; GO:0050714; GO:0005802 Q9H4A6 ADP binding; ATP binding; DNA binding; DNA metabolic process; Golgi organization; Golgi vesicle budding; actin filament binding; actomyosin; actomyosin structure organization; cell migration; endoplasmic reticulum-Golgi intermediate compartment; motor activity; myosin complex; negative regulation of apoptotic process; positive regulation of protein secretion; trans-Golgi network IPR000048; IPR027401; IPR001609; IPR002928; IPR027417; IPR001478; IPR020587; Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) MYO18A KIAA0216 MYSPDZ Homo sapiens (Human) TR36169_c7_g2_i1 Q076A5 MYH4_CANFA 0 GO:0005524; GO:0005925; GO:0003774; GO:0006936; GO:0030016; GO:0032982; GO:0005730; GO:0014823 ATP binding; focal adhesion; motor activity; muscle contraction; myofibril; myosin filament; nucleolus; response to activity IPR000048; IPR027401; IPR015650; IPR001609; IPR004009; IPR002928; IPR027417; Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) MYH4 Canis familiaris (Dog) (Canis lupus familiaris) TR36169_c7_g2_i2 P24733 MYS_AEQIR 0 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR015650; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, striated muscle" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR36169_c7_g2_i3 P24733 MYS_AEQIR 0 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR015650; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, striated muscle" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR36169_c8_g1_i1 Q875X3 MYO2A_NAUCC 3.00E-11 GO:0005524; GO:0007049; GO:0003774; GO:0016459; GO:0015031 ATP binding; cell cycle; motor activity; myosin complex; protein transport IPR018444; IPR002710; IPR000048; IPR001609; IPR008989; IPR027417; Myosin-2A (Class V unconventional myosin MYO2A) (Type V myosin heavy chain MYO2A) (Myosin V MYO2A) MYO2A NCAS_0I00130 Naumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii) TR36170_c0_g1_i1 B0V3H4 CS054_DANRE 2.00E-39 UPF0692 protein C19orf54 homolog si:dkey-233h2.2 zgc:153119 Danio rerio (Zebrafish) (Brachydanio rerio) TR36171_c3_g1_i1 A7E305 K0913_BOVIN 1.00E-103 GO:0008270 zinc ion binding IPR007527; Zinc finger SWIM domain-containing protein 8 ZSWIM8 Bos taurus (Bovine) TR36172_c1_g1_i1 Q9VN03 SUV3_DROME 0 GO:0005524; GO:0003677; GO:0003678; GO:0005759; GO:0005634 ATP binding; DNA binding; DNA helicase activity; mitochondrial matrix; nucleus IPR001650; IPR027417; IPR022192; "ATP-dependent RNA helicase SUV3 homolog, mitochondrial (EC 3.6.4.13)" CG9791 Drosophila melanogaster (Fruit fly) TR36173_c10_g1_i1 O60566 BUB1B_HUMAN 2.00E-38 GO:0005524; GO:0005680; GO:0031145; GO:0006915; GO:0051301; GO:0008283; GO:0000940; GO:0000778; GO:0005829; GO:0007091; GO:0005815; GO:0007067; GO:0007094; GO:0051436; GO:0048471; GO:0048015; GO:0004672; GO:0071459; GO:0034501; GO:0004674; GO:0051233; GO:0007051 O43684; Q12834; Q02224; Q92831; P0CG48 "ATP binding; anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; apoptotic process; cell division; cell proliferation; condensed chromosome outer kinetochore; condensed nuclear chromosome kinetochore; cytosol; metaphase/anaphase transition of mitotic cell cycle; microtubule organizing center; mitosis; mitotic spindle assembly checkpoint; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; perinuclear region of cytoplasm; phosphatidylinositol-mediated signaling; protein kinase activity; protein localization to chromosome, centromeric region; protein localization to kinetochore; protein serine/threonine kinase activity; spindle midzone; spindle organization" IPR015661; IPR011009; IPR013212; IPR000719; Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) BUB1B BUBR1 MAD3L SSK1 Homo sapiens (Human) TR36173_c5_g5_i2 O43683 BUB1_HUMAN 8.00E-56 GO:0005524; GO:0006915; GO:0051301; GO:0008283; GO:0007059; GO:0000777; GO:0000780; GO:0005829; GO:0007067; GO:0000278; GO:0007094; GO:0019048; GO:0004672; GO:0004674; GO:0007063 P03070 "ATP binding; apoptotic process; cell division; cell proliferation; chromosome segregation; condensed chromosome kinetochore; condensed nuclear chromosome, centromeric region; cytosol; mitosis; mitotic cell cycle; mitotic spindle assembly checkpoint; modulation by virus of host morphology or physiology; protein kinase activity; protein serine/threonine kinase activity; regulation of sister chromatid cohesion" IPR015661; IPR011009; IPR013212; IPR000719; IPR017441; IPR008271; Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) BUB1 BUB1L Homo sapiens (Human) TR36173_c6_g1_i1 Q56FG8 RL18_LYSTE 2.00E-94 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000039; IPR021131; 60S ribosomal protein L18 RpL18 Lysiphlebus testaceipes (Greenbugs aphid parastoid) TR36173_c6_g1_i2 Q95342 RL18_PIG 1.00E-50 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000039; IPR021131; IPR021132; 60S ribosomal protein L18 (Fragment) RPL18 Sus scrofa (Pig) TR36176_c0_g2_i1 F1MH24 AAK1_BOVIN 1.00E-68 GO:0035612; GO:0005524; GO:0005112; GO:0031252; GO:0030136; GO:0005905; GO:0006897; GO:0019897; GO:0045747; GO:0046777; GO:0004674; GO:0050821; GO:2000369; GO:0032880; GO:0043195 AP-2 adaptor complex binding; ATP binding; Notch binding; cell leading edge; clathrin-coated vesicle; coated pit; endocytosis; extrinsic to plasma membrane; positive regulation of Notch signaling pathway; protein autophosphorylation; protein serine/threonine kinase activity; protein stabilization; regulation of clathrin-mediated endocytosis; regulation of protein localization; terminal bouton IPR011009; IPR000719; IPR008271; AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) AAK1 Bos taurus (Bovine) TR36176_c0_g2_i2 Q8BHX1 HAUS1_MOUSE 8.00E-48 GO:0070652; GO:0051301; GO:0005813; GO:0051297; GO:0005737; GO:0005874; GO:0007067; GO:0051225; GO:0000922 HAUS complex; cell division; centrosome; centrosome organization; cytoplasm; microtubule; mitosis; spindle assembly; spindle pole IPR026243; HAUS augmin-like complex subunit 1 (Coiled-coil domain-containing protein 5) Haus1 Ccdc5 Mus musculus (Mouse) TR36176_c0_g2_i3 F1SPM8 AAK1_PIG 9.00E-65 GO:0035612; GO:0005524; GO:0005112; GO:0031252; GO:0030136; GO:0005905; GO:0006897; GO:0019897; GO:0045747; GO:0046777; GO:0004674; GO:0050821; GO:2000369; GO:0032880; GO:0043195 AP-2 adaptor complex binding; ATP binding; Notch binding; cell leading edge; clathrin-coated vesicle; coated pit; endocytosis; extrinsic to plasma membrane; positive regulation of Notch signaling pathway; protein autophosphorylation; protein serine/threonine kinase activity; protein stabilization; regulation of clathrin-mediated endocytosis; regulation of protein localization; terminal bouton IPR011009; IPR000719; IPR008271; AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) AAK1 Sus scrofa (Pig) TR36176_c0_g3_i1 Q91Z96 BMP2K_MOUSE 2.00E-59 GO:0005524; GO:0005634; GO:0019208; GO:0004672; GO:0004674; GO:0030500 ATP binding; nucleus; phosphatase regulator activity; protein kinase activity; protein serine/threonine kinase activity; regulation of bone mineralization IPR028182; IPR011009; IPR000719; IPR008271; BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) Bmp2k Bike Mus musculus (Mouse) TR36176_c0_g3_i3 Q9NSY1 BMP2K_HUMAN 2.00E-60 GO:0005524; GO:0005634; GO:0019208; GO:0004674; GO:0030500 ATP binding; nucleus; phosphatase regulator activity; protein serine/threonine kinase activity; regulation of bone mineralization IPR028182; IPR011009; IPR000719; IPR008271; BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) BMP2K BIKE HRIHFB2017 Homo sapiens (Human) TR36177_c4_g1_i1 Q645M6 FADD_BOVIN 2.00E-06 GO:0031265; GO:0097202; GO:0071260; GO:0051607; GO:0097191; GO:0045087; GO:0070265; GO:0043123; GO:0043065; GO:2001238; GO:0032757; GO:0045862; GO:0045944; GO:0032760; GO:0060340 CD95 death-inducing signaling complex; activation of cysteine-type endopeptidase activity; cellular response to mechanical stimulus; defense response to virus; extrinsic apoptotic signaling pathway; innate immune response; necrotic cell death; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptotic process; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of interleukin-8 production; positive regulation of proteolysis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; positive regulation of type I interferon-mediated signaling pathway IPR011029; IPR000488; IPR001875; IPR016729; Protein FADD (FAS-associated death domain protein) (FAS-associating death domain-containing protein) FADD Bos taurus (Bovine) TR36181_c1_g1_i1 Q5XI81 FXR1_RAT 4.00E-132 GO:0003723; GO:0030154; GO:0005737; GO:0007517 RNA binding; cell differentiation; cytoplasm; muscle organ development IPR008395; IPR022034; IPR004087; IPR004088; Fragile X mental retardation syndrome-related protein 1 Fxr1 Fxr1h Rattus norvegicus (Rat) TR36181_c1_g1_i4 Q5XI81 FXR1_RAT 1.00E-134 GO:0003723; GO:0030154; GO:0005737; GO:0007517 RNA binding; cell differentiation; cytoplasm; muscle organ development IPR008395; IPR022034; IPR004087; IPR004088; Fragile X mental retardation syndrome-related protein 1 Fxr1 Fxr1h Rattus norvegicus (Rat) TR36182_c0_g1_i1 Q8K4Q7 CERK1_MOUSE 1.00E-49 GO:0005524; GO:0003951; GO:0001729; GO:0006672; GO:0004143; GO:0016021; GO:0000287; GO:0005739; GO:0005634; GO:0007205 ATP binding; NAD+ kinase activity; ceramide kinase activity; ceramide metabolic process; diacylglycerol kinase activity; integral to membrane; magnesium ion binding; mitochondrion; nucleus; protein kinase C-activating G-protein coupled receptor signaling pathway IPR016064; IPR001206; Ceramide kinase (mCERK) (EC 2.7.1.138) (Acylsphingosine kinase) Cerk Mus musculus (Mouse) TR36182_c0_g1_i2 Q8TCT0 CERK1_HUMAN 5.00E-51 GO:0005524; GO:0003951; GO:0001729; GO:0006672; GO:0005737; GO:0004143; GO:0006687; GO:0016021; GO:0000287; GO:0005739; GO:0005634; GO:0005543; GO:0005886; GO:0007205; GO:0044281 ATP binding; NAD+ kinase activity; ceramide kinase activity; ceramide metabolic process; cytoplasm; diacylglycerol kinase activity; glycosphingolipid metabolic process; integral to membrane; magnesium ion binding; mitochondrion; nucleus; phospholipid binding; plasma membrane; protein kinase C-activating G-protein coupled receptor signaling pathway; small molecule metabolic process IPR016064; IPR001206; IPR001849; Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) TR36182_c0_g1_i3 Q8TCT0 CERK1_HUMAN 1.00E-31 GO:0005524; GO:0003951; GO:0001729; GO:0006672; GO:0005737; GO:0004143; GO:0006687; GO:0016021; GO:0000287; GO:0005739; GO:0005634; GO:0005543; GO:0005886; GO:0007205; GO:0044281 ATP binding; NAD+ kinase activity; ceramide kinase activity; ceramide metabolic process; cytoplasm; diacylglycerol kinase activity; glycosphingolipid metabolic process; integral to membrane; magnesium ion binding; mitochondrion; nucleus; phospholipid binding; plasma membrane; protein kinase C-activating G-protein coupled receptor signaling pathway; small molecule metabolic process IPR016064; IPR001206; IPR001849; Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) TR36183_c7_g1_i3 Q96MD2 CL066_HUMAN 3.00E-61 IPR018544; UPF0536 protein C12orf66 C12orf66 Homo sapiens (Human) TR36183_c8_g2_i1 Q96MM6 HS12B_HUMAN 1.00E-19 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR36189_c0_g1_i1 Q9BRS2 RIOK1_HUMAN 1.00E-168 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR018934; IPR000687; IPR018935; IPR017407; Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (RIO kinase 1) RIOK1 Homo sapiens (Human) TR36189_c1_g1_i1 Q5ZJ24 FOPNL_CHICK 2.00E-29 GO:0034451; GO:0042384; GO:0034453; GO:0005932; GO:0031514 centriolar satellite; cilium assembly; microtubule anchoring; microtubule basal body; motile cilium IPR018993; IPR006594; LisH domain-containing protein FOPNL (FGFR1OP N-terminal-like protein) FOPNL RCJMB04_21j4 Gallus gallus (Chicken) TR36192_c0_g1_i2 Q9HFF5 PDS5_SCHPO 6.00E-24 GO:0051455; GO:0051301; GO:0000775; GO:0000794; GO:0030892; GO:0000070; GO:0071459; GO:2000817; GO:0006974; GO:0007062 "attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation; cell division; chromosome, centromeric region; condensed nuclear chromosome; mitotic cohesin complex; mitotic sister chromatid segregation; protein localization to chromosome, centromeric region; regulation of histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore; response to DNA damage stimulus; sister chromatid cohesion" IPR011989; IPR016024; Sister chromatid cohesion protein pds5 (Precocious dissociation of sisters protein 5) pds5 SPAC110.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36192_c1_g2_i1 Q5F3U9 PDS5B_CHICK 2.00E-138 GO:0051301; GO:0007064; GO:0008285; GO:0005634 cell division; mitotic sister chromatid cohesion; negative regulation of cell proliferation; nucleus IPR011989; IPR016024; Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) PDS5B APRIN RCJMB04_6g19 Gallus gallus (Chicken) TR36192_c2_g1_i1 Q5F3U9 PDS5B_CHICK 3.00E-120 GO:0051301; GO:0007064; GO:0008285; GO:0005634 cell division; mitotic sister chromatid cohesion; negative regulation of cell proliferation; nucleus IPR011989; IPR016024; Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) PDS5B APRIN RCJMB04_6g19 Gallus gallus (Chicken) TR36193_c3_g2_i1 Q9BYX4 IFIH1_HUMAN 2.00E-18 GO:0005524; GO:0003677; GO:0039528; GO:0005829; GO:0009597; GO:0003725; GO:0004386; GO:0045087; GO:0019048; GO:0032480; GO:0005634; GO:0032727; GO:0032728; GO:0016925; GO:0042981; GO:0034344; GO:0043021; GO:0003727; GO:0008270 Q7Z434; P11207; P30927; Q9EMA9; P04487 ATP binding; DNA binding; cytoplasmic pattern recognition receptor signaling pathway in response to virus; cytosol; detection of virus; double-stranded RNA binding; helicase activity; innate immune response; modulation by virus of host morphology or physiology; negative regulation of type I interferon production; nucleus; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; protein sumoylation; regulation of apoptotic process; regulation of type III interferon production; ribonucleoprotein complex binding; single-stranded RNA binding; zinc ion binding IPR001315; IPR011029; IPR006935; IPR014001; IPR001650; IPR027417; IPR021673; Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116) IFIH1 MDA5 RH116 Homo sapiens (Human) TR36195_c0_g1_i1 Q92614 MY18A_HUMAN 1.00E-112 GO:0043531; GO:0005524; GO:0003677; GO:0006259; GO:0007030; GO:0048194; GO:0051015; GO:0042641; GO:0031032; GO:0016477; GO:0005793; GO:0003774; GO:0016459; GO:0043066; GO:0050714; GO:0005802 Q9H4A6 ADP binding; ATP binding; DNA binding; DNA metabolic process; Golgi organization; Golgi vesicle budding; actin filament binding; actomyosin; actomyosin structure organization; cell migration; endoplasmic reticulum-Golgi intermediate compartment; motor activity; myosin complex; negative regulation of apoptotic process; positive regulation of protein secretion; trans-Golgi network IPR000048; IPR027401; IPR001609; IPR002928; IPR027417; IPR001478; IPR020587; Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) MYO18A KIAA0216 MYSPDZ Homo sapiens (Human) TR36195_c0_g2_i1 Q9NY99 SNTG2_HUMAN 8.00E-08 GO:0007417; GO:0005737; GO:0005856; GO:0005543; GO:0042383; GO:0016013 central nervous system development; cytoplasm; cytoskeleton; phospholipid binding; sarcolemma; syntrophin complex IPR001478; IPR001849; IPR015482; Gamma-2-syntrophin (G2SYN) (Syntrophin-5) (SYN5) SNTG2 Homo sapiens (Human) TR36196_c3_g1_i1 P97414 KCNQ1_MOUSE 0 GO:0016323; GO:0072358; GO:0030659; GO:0005251; GO:0005769; GO:0016458; GO:0005770; GO:0005764; GO:1901381; GO:0071435; GO:0006349; GO:0060306; GO:0008076 basolateral plasma membrane; cardiovascular system development; cytoplasmic vesicle membrane; delayed rectifier potassium channel activity; early endosome; gene silencing; late endosome; lysosome; positive regulation of potassium ion transmembrane transport; potassium ion export; regulation of gene expression by genetic imprinting; regulation of membrane repolarization; voltage-gated potassium channel complex IPR005821; IPR003091; IPR003937; IPR013821; IPR005827; IPR028325; Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1) Kcnq1 Kcna9 Kvlqt1 Mus musculus (Mouse) TR36196_c5_g2_i1 Q71F56 MD13L_HUMAN 1.00E-103 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR009401; IPR021643; Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) MED13L KIAA1025 PROSIT240 THRAP2 TRAP240L Homo sapiens (Human) TR36196_c5_g3_i1 A2VCZ5 MD13L_DANRE 9.00E-90 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR009401; IPR021643; Mediator of RNA polymerase II transcription subunit 13-like (Thyroid hormone receptor-associated protein complex 240 kDa component-like protein) zgc:153454 Danio rerio (Zebrafish) (Brachydanio rerio) TR36198_c0_g1_i1 Q5ZL33 STRAP_CHICK 5.00E-120 GO:0008380; GO:0030054; GO:0006397; GO:0005739; GO:0000122; GO:0030512; GO:0005886; GO:0005102; GO:0005681 RNA splicing; cell junction; mRNA processing; mitochondrion; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; plasma membrane; receptor binding; spliceosomal complex IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Serine-threonine kinase receptor-associated protein STRAP RCJMB04_7p19 Gallus gallus (Chicken) TR362_c0_g1_i1 P61354 RL27_RAT 9.00E-72 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR005824; IPR014722; IPR001141; IPR018262; IPR008991; 60S ribosomal protein L27 Rpl27 Rattus norvegicus (Rat) TR36200_c0_g1_i1 Q8N6F8 WBS27_HUMAN 2.00E-10 Williams-Beuren syndrome chromosomal region 27 protein WBSCR27 Homo sapiens (Human) TR36202_c0_g1_i1 Q6IR55 TM129_XENLA 1.00E-134 GO:0016021 integral to membrane IPR018801; Transmembrane protein 129 tmem129 Xenopus laevis (African clawed frog) TR36203_c0_g1_i1 O69269 DNAJ_LYSSH 2.00E-15 GO:0005524; GO:0006260; GO:0005737; GO:0006457; GO:0009408; GO:0008270 ATP binding; DNA replication; cytoplasm; protein folding; response to heat; zinc ion binding IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; Chaperone protein DnaJ dnaJ Lysinibacillus sphaericus (Bacillus sphaericus) TR36203_c0_g1_i2 Q9UBS3 DNJB9_HUMAN 1.00E-29 GO:0030433; GO:0006987; GO:0005788; GO:0005789; GO:0051787; GO:0005730 ER-associated protein catabolic process; activation of signaling protein activity involved in unfolded protein response; endoplasmic reticulum lumen; endoplasmic reticulum membrane; misfolded protein binding; nucleolus IPR001623; IPR018253; DnaJ homolog subfamily B member 9 (Endoplasmic reticulum DNA J domain-containing protein 4) (ER-resident protein ERdj4) (ERdj4) (Microvascular endothelial differentiation gene 1 protein) (Mdg-1) DNAJB9 MDG1 UNQ743/PRO1471 Homo sapiens (Human) TR36203_c0_g1_i3 Q95KD5 DJC18_MACFA 5.00E-16 GO:0016021 integral to membrane IPR001623; IPR018253; IPR015399; DnaJ homolog subfamily C member 18 DNAJC18 QflA-15848 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR36204_c0_g1_i2 Q86WA6 BPHL_HUMAN 8.00E-37 GO:0006520; GO:0016787; GO:0005739; GO:0009636 cellular amino acid metabolic process; hydrolase activity; mitochondrion; response to toxic substance Valacyclovir hydrolase (VACVase) (Valacyclovirase) (EC 3.1.-.-) (Biphenyl hydrolase-like protein) (Biphenyl hydrolase-related protein) (Bph-rp) (Breast epithelial mucin-associated antigen) (MCNAA) BPHL MCNAA Homo sapiens (Human) TR36204_c0_g3_i1 Q8R164 BPHL_MOUSE 2.00E-26 GO:0016787; GO:0005739 hydrolase activity; mitochondrion Valacyclovir hydrolase (VACVase) (Valacyclovirase) (EC 3.1.-.-) (Biphenyl hydrolase-like protein) Bphl Mus musculus (Mouse) TR36207_c0_g2_i1 B1WAZ6 PA24A_XENTR 1.00E-130 GO:0016023; GO:0004622; GO:0046872; GO:0004623; GO:0009395 cytoplasmic membrane-bounded vesicle; lysophospholipase activity; metal ion binding; phospholipase A2 activity; phospholipid catabolic process IPR016035; IPR000008; IPR002642; Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] pla2g4a cpla2 pla2g4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36207_c0_g2_i2 Q68DD2 PA24F_HUMAN 8.00E-44 GO:0050482; GO:0047498; GO:0071236; GO:0071407; GO:0005829; GO:0046474; GO:0004622; GO:0005765; GO:0046872; GO:0036151; GO:0036152; GO:0036148; GO:0036149; GO:0036150; GO:0009395; GO:0001516; GO:0032587; GO:0031982 arachidonic acid secretion; calcium-dependent phospholipase A2 activity; cellular response to antibiotic; cellular response to organic cyclic compound; cytosol; glycerophospholipid biosynthetic process; lysophospholipase activity; lysosomal membrane; metal ion binding; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; phosphatidylinositol acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; phospholipid catabolic process; prostaglandin biosynthetic process; ruffle membrane; vesicle IPR016035; IPR000008; IPR002642; Cytosolic phospholipase A2 zeta (cPLA2-zeta) (EC 3.1.1.4) (Phospholipase A2 group IVF) PLA2G4F Homo sapiens (Human) TR36207_c0_g3_i1 A0JJX5 SYT4_ARATH 3.00E-09 GO:0016021; GO:0008289; GO:0046872 integral to membrane; lipid binding; metal ion binding IPR000008; Synaptotagmin-4 (NTMC2T2.2) (Synaptotagmin D) SYT4 SYTD At5g11100 T5K6.90 Arabidopsis thaliana (Mouse-ear cress) TR36207_c0_g3_i5 P49147 PA24A_CHICK 7.00E-42 GO:0005794; GO:0050482; GO:0005509; GO:0047498; GO:0005544; GO:0071236; GO:0016023; GO:0005829; GO:0005783; GO:0046456; GO:0004622; GO:0009395; GO:0042127 Golgi apparatus; arachidonic acid secretion; calcium ion binding; calcium-dependent phospholipase A2 activity; calcium-dependent phospholipid binding; cellular response to antibiotic; cytoplasmic membrane-bounded vesicle; cytosol; endoplasmic reticulum; icosanoid biosynthetic process; lysophospholipase activity; phospholipid catabolic process; regulation of cell proliferation IPR016035; IPR000008; IPR002642; Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] PLA2G4A CPLA2 PLA2G4 Gallus gallus (Chicken) TR36208_c0_g1_i1 Q2M2N2 SPOPL_MOUSE 6.00E-11 GO:0031463; GO:0031397; GO:0005634; GO:0043161; GO:0016567 Cul3-RING ubiquitin ligase complex; negative regulation of protein ubiquitination; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination IPR000210; IPR011333; IPR013069; IPR002083; IPR008974; Protein modification; protein ubiquitination. Speckle-type POZ protein-like (HIB homolog 2) Spopl Mus musculus (Mouse) TR36208_c2_g1_i2 Q07230 ZSCA2_MOUSE 4.00E-38 GO:0003677; GO:0030154; GO:0046872; GO:0007275; GO:0005634; GO:0003700; GO:0007283; GO:0006351 "DNA binding; cell differentiation; metal ion binding; multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity; spermatogenesis; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29) (Zfp-29) Zscan2 Zfp-29 Zfp29 Mus musculus (Mouse) TR36209_c2_g2_i2 A6NEE1 PLHD1_HUMAN 3.00E-87 GO:0005543 phospholipid binding IPR011993; IPR001849; Pleckstrin homology domain-containing family D member 1 (PH domain-containing family D member 1) PLEKHD1 Homo sapiens (Human) TR36209_c2_g2_i4 A6NEE1 PLHD1_HUMAN 7.00E-88 GO:0005543 phospholipid binding IPR011993; IPR001849; Pleckstrin homology domain-containing family D member 1 (PH domain-containing family D member 1) PLEKHD1 Homo sapiens (Human) TR36209_c3_g1_i6 Q8N357 CB018_HUMAN 2.00E-22 GO:0005794; GO:0016021; GO:0005765; GO:0005739; GO:1901029; GO:0005634; GO:0008284; GO:0006810 P05141 Golgi apparatus; integral to membrane; lysosomal membrane; mitochondrion; negative regulation of mitochondrial outer membrane permeabilization; nucleus; positive regulation of cell proliferation; transport IPR009262; IPR012404; Solute carrier family 35 member F6 (ANT2-binding protein) (ANT2BP) (Transport and Golgi organization 9 homolog) SLC35F6 C2orf18 UNQ3047/PRO9863 Homo sapiens (Human) TR36209_c3_g2_i1 Q8N357 CB018_HUMAN 4.00E-33 GO:0005794; GO:0016021; GO:0005765; GO:0005739; GO:1901029; GO:0005634; GO:0008284; GO:0006810 P05141 Golgi apparatus; integral to membrane; lysosomal membrane; mitochondrion; negative regulation of mitochondrial outer membrane permeabilization; nucleus; positive regulation of cell proliferation; transport IPR009262; IPR012404; Solute carrier family 35 member F6 (ANT2-binding protein) (ANT2BP) (Transport and Golgi organization 9 homolog) SLC35F6 C2orf18 UNQ3047/PRO9863 Homo sapiens (Human) TR36210_c0_g2_i1 P46938 YAP1_MOUSE 1.00E-14 GO:0006975; GO:0001076; GO:0008283; GO:0071480; GO:0003682; GO:0060242; GO:0005737; GO:0003143; GO:0035329; GO:0030216; GO:0048368; GO:0030857; GO:2001237; GO:0030903; GO:0005634; GO:0048339; GO:0090263; GO:0008284; GO:0046622; GO:0045944; GO:0010837; GO:0072091; GO:0035019; GO:0003713; GO:0003714; GO:0005667; GO:0044212; GO:0001570 Q9JJP2 DNA damage induced protein phosphorylation; RNA polymerase II transcription factor binding transcription factor activity; cell proliferation; cellular response to gamma radiation; chromatin binding; contact inhibition; cytoplasm; embryonic heart tube morphogenesis; hippo signaling cascade; keratinocyte differentiation; lateral mesoderm development; negative regulation of epithelial cell differentiation; negative regulation of extrinsic apoptotic signaling pathway; notochord development; nucleus; paraxial mesoderm development; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell proliferation; positive regulation of organ growth; positive regulation of transcription from RNA polymerase II promoter; regulation of keratinocyte proliferation; regulation of stem cell proliferation; somatic stem cell maintenance; transcription coactivator activity; transcription corepressor activity; transcription factor complex; transcription regulatory region DNA binding; vasculogenesis IPR001202; Yorkie homolog (65 kDa Yes-associated protein) (YAP65) Yap1 Yap Yap65 Mus musculus (Mouse) TR36210_c0_g2_i4 Q8BZZ3 WWP1_MOUSE 0 GO:0030217; GO:0005737; GO:0030324; GO:0045892; GO:0005634; GO:0005886; GO:0043161; GO:0042787; GO:0004842 "T cell differentiation; cytoplasm; lung development; negative regulation of transcription, DNA-dependent; nucleus; plasma membrane; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity" IPR000008; IPR024928; IPR000569; IPR001202; Protein modification; protein ubiquitination. NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain-containing protein 1) Wwp1 Mus musculus (Mouse) TR36211_c0_g1_i1 Q17QE5 CIB1_BOVIN 5.00E-40 GO:0016324; GO:0006915; GO:0005509; GO:0007113; GO:0005783; GO:0030175; GO:0008285; GO:0005654; GO:0070886; GO:0090004; GO:0006974; GO:0042383 apical plasma membrane; apoptotic process; calcium ion binding; endomitotic cell cycle; endoplasmic reticulum; filopodium; negative regulation of cell proliferation; nucleoplasm; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of establishment of protein localization to plasma membrane; response to DNA damage stimulus; sarcolemma IPR011992; IPR018247; IPR002048; Calcium and integrin-binding protein 1 (Calmyrin) CIB1 Bos taurus (Bovine) TR36211_c0_g1_i2 Q96Q77 CIB3_HUMAN 1.00E-37 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calcium and integrin-binding family member 3 (Kinase-interacting protein 3) (KIP 3) CIB3 KIP3 Homo sapiens (Human) TR36212_c0_g2_i3 Q3URF8 KCD21_MOUSE 3.00E-14 GO:0051260 protein homooligomerization IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein KCTD21 Kctd21 Mus musculus (Mouse) TR36212_c0_g2_i4 A4IFB4 KCTD7_BOVIN 3.00E-16 GO:0005829; GO:0005886; GO:0051260 cytosol; plasma membrane; protein homooligomerization IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein KCTD7 KCTD7 Bos taurus (Bovine) TR36213_c2_g1_i2 Q6PK04 CC137_HUMAN 2.00E-09 IPR026680; Coiled-coil domain-containing protein 137 CCDC137 Homo sapiens (Human) TR36213_c2_g1_i3 Q8R0K4 CC137_MOUSE 1.00E-10 IPR026680; Coiled-coil domain-containing protein 137 Ccdc137 Mus musculus (Mouse) TR36213_c3_g1_i1 A8MTL3 CN164_HUMAN 3.00E-24 GO:0008270 zinc ion binding IPR001841; IPR017907; RING finger protein C14orf164 C14orf164 Homo sapiens (Human) TR36213_c5_g1_i1 Q8HXX6 SAP3_MACFA 1.00E-15 GO:0016787; GO:0005764; GO:0006665 hydrolase activity; lysosome; sphingolipid metabolic process IPR003172; Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) GM2A QccE-17591 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR36215_c0_g1_i1 Q5G271 NETR_PANTR 2.00E-22 GO:0030424; GO:0031410; GO:0030425; GO:0006887; GO:0005576; GO:0005886; GO:0006508; GO:0005044; GO:0004252; GO:0043083; GO:0043195; GO:0031638 axon; cytoplasmic vesicle; dendrite; exocytosis; extracellular region; plasma membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity; synaptic cleft; terminal bouton; zymogen activation IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR001190; IPR017448; IPR009003; Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Pan troglodytes (Chimpanzee) TR36216_c0_g1_i2 Q9UQ90 SPG7_HUMAN 2.00E-119 GO:0005524; GO:0008089; GO:0008219; GO:0016021; GO:0004222; GO:0031966; GO:0005739; GO:0007005; GO:0007399; GO:0017111; GO:0006508; GO:0051082; GO:0008270 ATP binding; anterograde axon cargo transport; cell death; integral to membrane; metalloendopeptidase activity; mitochondrial membrane; mitochondrion; mitochondrion organization; nervous system development; nucleoside-triphosphatase activity; proteolysis; unfolded protein binding; zinc ion binding IPR003593; IPR003959; IPR005936; IPR027417; IPR011546; IPR000642; Paraplegin (EC 3.4.24.-) (Spastic paraplegia 7 protein) SPG7 CAR CMAR PGN Homo sapiens (Human) TR36216_c0_g1_i3 Q9UQ90 SPG7_HUMAN 8.00E-147 GO:0005524; GO:0008089; GO:0008219; GO:0016021; GO:0004222; GO:0031966; GO:0005739; GO:0007005; GO:0007399; GO:0017111; GO:0006508; GO:0051082; GO:0008270 ATP binding; anterograde axon cargo transport; cell death; integral to membrane; metalloendopeptidase activity; mitochondrial membrane; mitochondrion; mitochondrion organization; nervous system development; nucleoside-triphosphatase activity; proteolysis; unfolded protein binding; zinc ion binding IPR003593; IPR003959; IPR005936; IPR027417; IPR011546; IPR000642; Paraplegin (EC 3.4.24.-) (Spastic paraplegia 7 protein) SPG7 CAR CMAR PGN Homo sapiens (Human) TR36217_c1_g1_i1 O73888 HPGDS_CHICK 3.00E-38 GO:0005509; GO:0005737; GO:0004364; GO:0000287; GO:0005634; GO:0001516; GO:0006693; GO:0004667 calcium ion binding; cytoplasm; glutathione transferase activity; magnesium ion binding; nucleus; prostaglandin biosynthetic process; prostaglandin metabolic process; prostaglandin-D synthase activity IPR010987; IPR004045; IPR004046; IPR012336; Hematopoietic prostaglandin D synthase (H-PGDS) (EC 5.3.99.2) (GST class-sigma) (Glutathione S-transferase) (EC 2.5.1.18) (Glutathione-dependent PGD synthase) (Glutathione-requiring prostaglandin D synthase) (Prostaglandin-H2 D-isomerase) HPGDS GSTS PGDS PTGDS2 Gallus gallus (Chicken) TR36217_c1_g1_i3 P27012 SCRY4_ENTDO 5.00E-37 GO:0005212 structural constituent of eye lens IPR010987; IPR004045; IPR004046; IPR003083; IPR012336; S-crystallin 4 (OL4) Enteroctopus dofleini (Giant octopus) (Octopus dofleini) TR36217_c1_g1_i4 P27016 SCR18_OMMSL 1.00E-15 GO:0005212 structural constituent of eye lens IPR010987; IPR004045; IPR004046; IPR003083; IPR012336; S-crystallin SL18 Ommastrephes sloanei (Arrow squid) (Sloane's squid) TR36217_c1_g1_i6 P18425 SCR20_OMMSL 1.00E-29 GO:0005212 structural constituent of eye lens IPR010987; IPR004045; IPR004046; IPR003083; IPR012336; S-crystallin SL20-1 (Major lens polypeptide) Ommastrephes sloanei (Arrow squid) (Sloane's squid) TR36217_c1_g1_i7 O73888 HPGDS_CHICK 9.00E-40 GO:0005509; GO:0005737; GO:0004364; GO:0000287; GO:0005634; GO:0001516; GO:0006693; GO:0004667 calcium ion binding; cytoplasm; glutathione transferase activity; magnesium ion binding; nucleus; prostaglandin biosynthetic process; prostaglandin metabolic process; prostaglandin-D synthase activity IPR010987; IPR004045; IPR004046; IPR012336; Hematopoietic prostaglandin D synthase (H-PGDS) (EC 5.3.99.2) (GST class-sigma) (Glutathione S-transferase) (EC 2.5.1.18) (Glutathione-dependent PGD synthase) (Glutathione-requiring prostaglandin D synthase) (Prostaglandin-H2 D-isomerase) HPGDS GSTS PGDS PTGDS2 Gallus gallus (Chicken) TR36218_c7_g1_i1 Q9Z221 PMFBP_RAT 3.00E-08 GO:0007010; GO:0001520 cytoskeleton organization; outer dense fiber Polyamine-modulated factor 1-binding protein 1 (PMF-1-binding protein) (Outer dense fiber protein 3) Pmfbp1 Odf3 Rattus norvegicus (Rat) TR36218_c7_g2_i1 Q8TBY8 PMFBP_HUMAN 3.00E-06 GO:0005737 cytoplasm Polyamine-modulated factor 1-binding protein 1 (PMF-1-binding protein) PMFBP1 Homo sapiens (Human) TR36219_c2_g3_i1 Q3BAI2 YCX91_PHAAO 2.00E-11 GO:0009507 chloroplast Uncharacterized protein ORF91 Phalaenopsis aphrodite subsp. formosana (Moth orchid) TR36220_c0_g1_i1 Q14590 ZN235_HUMAN 7.00E-16 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) TR36220_c0_g1_i2 Q8BKX7 ZN410_MOUSE 1.00E-22 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 410 (Another partner for ARF 1) (Zinc finger protein APA-1) Znf410 Apa1 D12Ertd748e Zfp410 Mus musculus (Mouse) TR36220_c1_g2_i1 Q14590 ZN235_HUMAN 4.00E-63 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) TR36220_c1_g2_i2 P35789 ZNF93_HUMAN 3.00E-62 GO:0003677; GO:0005634; GO:0003700; GO:0006351; GO:0008270 "DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 93 (Zinc finger protein 505) (Zinc finger protein HTF34) ZNF93 ZNF505 Homo sapiens (Human) TR36221_c1_g2_i1 P42327 ADH2_GEOSE 5.00E-27 GO:0004022; GO:0008270 alcohol dehydrogenase (NAD) activity; zinc ion binding IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; Alcohol dehydrogenase (ADH) (EC 1.1.1.1) adh Geobacillus stearothermophilus (Bacillus stearothermophilus) TR36221_c1_g2_i2 P81600 ADHH_GADMO 1.00E-131 GO:0051903; GO:0004022; GO:0005737; GO:0006069; GO:0008270 S-(hydroxymethyl)glutathione dehydrogenase activity; alcohol dehydrogenase (NAD) activity; cytoplasm; ethanol oxidation; zinc ion binding IPR014183; IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; Alcohol dehydrogenase class-3 chain H (EC 1.1.1.1) (Alcohol dehydrogenase class-III chain H) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) Gadus morhua (Atlantic cod) TR36221_c1_g2_i3 Q3ZC42 ADHX_BOVIN 2.00E-135 GO:0051903; GO:0004022; GO:0006069; GO:0005504; GO:0046294; GO:0018467; GO:0005739; GO:0018119; GO:0045777; GO:0003016; GO:0032496; GO:0051409; GO:0051775; GO:0001523; GO:0008270 S-(hydroxymethyl)glutathione dehydrogenase activity; alcohol dehydrogenase (NAD) activity; ethanol oxidation; fatty acid binding; formaldehyde catabolic process; formaldehyde dehydrogenase activity; mitochondrion; peptidyl-cysteine S-nitrosylation; positive regulation of blood pressure; respiratory system process; response to lipopolysaccharide; response to nitrosative stress; response to redox state; retinoid metabolic process; zinc ion binding IPR014183; IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) ADH5 Bos taurus (Bovine) TR36221_c1_g2_i4 Q3ZC42 ADHX_BOVIN 4.00E-101 GO:0051903; GO:0004022; GO:0006069; GO:0005504; GO:0046294; GO:0018467; GO:0005739; GO:0018119; GO:0045777; GO:0003016; GO:0032496; GO:0051409; GO:0051775; GO:0001523; GO:0008270 S-(hydroxymethyl)glutathione dehydrogenase activity; alcohol dehydrogenase (NAD) activity; ethanol oxidation; fatty acid binding; formaldehyde catabolic process; formaldehyde dehydrogenase activity; mitochondrion; peptidyl-cysteine S-nitrosylation; positive regulation of blood pressure; respiratory system process; response to lipopolysaccharide; response to nitrosative stress; response to redox state; retinoid metabolic process; zinc ion binding IPR014183; IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) ADH5 Bos taurus (Bovine) TR36224_c0_g2_i2 P49696 SYVC_TAKRU 0 GO:0005524; GO:0002161; GO:0005737; GO:0006450; GO:0004832; GO:0006438 ATP binding; aminoacyl-tRNA editing activity; cytoplasm; regulation of translational fidelity; valine-tRNA ligase activity; valyl-tRNA aminoacylation IPR001412; IPR002300; IPR010987; IPR004046; IPR014729; IPR010978; IPR009080; IPR013155; IPR019499; IPR009008; IPR002303; Valine--tRNA ligase (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) vars vars1 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR36226_c0_g2_i1 Q921F2 TADBP_MOUSE 3.00E-115 GO:0070935; GO:0001205; GO:0008380; GO:0003690; GO:0003730; GO:0006397; GO:0043922; GO:0000166; GO:0005634 3'-UTR-mediated mRNA stabilization; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA splicing; double-stranded DNA binding; mRNA 3'-UTR binding; mRNA processing; negative regulation by host of viral transcription; nucleotide binding; nucleus IPR012677; IPR000504; TAR DNA-binding protein 43 (TDP-43) Tardbp Tdp43 Mus musculus (Mouse) TR36226_c0_g2_i5 Q9H0Z9 RBM38_HUMAN 2.00E-08 GO:0070935; GO:0006977; GO:0006978; GO:0008380; GO:0007049; GO:0007050; GO:0030154; GO:0005829; GO:0003730; GO:0003729; GO:0006397; GO:0008285; GO:0000166; GO:0005634; GO:0043484; GO:0010830 "3'-UTR-mediated mRNA stabilization; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; RNA splicing; cell cycle; cell cycle arrest; cell differentiation; cytosol; mRNA 3'-UTR binding; mRNA binding; mRNA processing; negative regulation of cell proliferation; nucleotide binding; nucleus; regulation of RNA splicing; regulation of myotube differentiation" IPR012677; IPR000504; RNA-binding protein 38 (CLL-associated antigen KW-5) (HSRNASEB) (RNA-binding motif protein 38) (RNA-binding region-containing protein 1) (ssDNA-binding protein SEB4) RBM38 RNPC1 SEB4 Homo sapiens (Human) TR36226_c0_g2_i6 Q921F2 TADBP_MOUSE 3.00E-115 GO:0070935; GO:0001205; GO:0008380; GO:0003690; GO:0003730; GO:0006397; GO:0043922; GO:0000166; GO:0005634 3'-UTR-mediated mRNA stabilization; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA splicing; double-stranded DNA binding; mRNA 3'-UTR binding; mRNA processing; negative regulation by host of viral transcription; nucleotide binding; nucleus IPR012677; IPR000504; TAR DNA-binding protein 43 (TDP-43) Tardbp Tdp43 Mus musculus (Mouse) TR36227_c0_g2_i1 Q9BV44 THUM3_HUMAN 2.00E-78 GO:0003723; GO:0008168 RNA binding; methyltransferase activity IPR000241; IPR004114; THUMP domain-containing protein 3 THUMPD3 Homo sapiens (Human) TR36227_c0_g2_i2 Q2T9W2 THUM3_BOVIN 3.00E-93 GO:0003723; GO:0008168 RNA binding; methyltransferase activity IPR000241; IPR004114; THUMP domain-containing protein 3 THUMPD3 Bos taurus (Bovine) TR36227_c0_g2_i3 Q2T9W2 THUM3_BOVIN 3.00E-50 GO:0003723; GO:0008168 RNA binding; methyltransferase activity IPR000241; IPR004114; THUMP domain-containing protein 3 THUMPD3 Bos taurus (Bovine) TR36228_c0_g1_i1 Q09575 YRD6_CAEEL 1.00E-69 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR36229_c0_g1_i2 Q0E587 MMP_SFAVA 9.00E-09 GO:0031012; GO:0004222; GO:0006508; GO:0008270 extracellular matrix; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR001818; IPR021190; IPR006026; Putative matrix metalloproteinase (EC 3.4.24.-) ORF14 Spodoptera frugiperda ascovirus 1a (SfAV-1a) TR36229_c0_g1_i5 P48819 VTNC_PIG 5.00E-10 GO:0007155; GO:0005615; GO:0008201; GO:0006955; GO:0030247; GO:0005044 cell adhesion; extracellular space; heparin binding; immune response; polysaccharide binding; scavenger receptor activity IPR000585; IPR018487; IPR018486; IPR020436; IPR001212; Vitronectin (VN) (S-protein) (Serum-spreading factor) VTN Sus scrofa (Pig) TR36229_c0_g1_i7 Q9R0S3 MMP17_MOUSE 4.00E-41 GO:0031225; GO:0005509; GO:0004222; GO:0005886; GO:0005578; GO:0006508; GO:0008270 anchored to membrane; calcium ion binding; metalloendopeptidase activity; plasma membrane; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000585; IPR018487; IPR024079; IPR001818; IPR021190; IPR016293; IPR006026; IPR002477; Matrix metalloproteinase-17 (MMP-17) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (MTMMP4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP) (MT4MMP) Mmp17 Mt4mmp Mus musculus (Mouse) TR36229_c0_g1_i8 Q9ULZ9 MMP17_HUMAN 2.00E-21 GO:0031225; GO:0005509; GO:0008047; GO:0005887; GO:0004222; GO:0005578; GO:0006508; GO:0008270 anchored to membrane; calcium ion binding; enzyme activator activity; integral to plasma membrane; metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000585; IPR018487; IPR024079; IPR001818; IPR021190; IPR016293; IPR006026; IPR002477; Matrix metalloproteinase-17 (MMP-17) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (MTMMP4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP) (MT4MMP) MMP17 MT4MMP Homo sapiens (Human) TR36230_c1_g1_i1 Q9CZJ2 HS12B_MOUSE 7.00E-22 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR36230_c5_g1_i1 O43301 HS12A_HUMAN 7.00E-21 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR36230_c7_g1_i1 P17105 IP3KA_RAT 2.00E-87 GO:0005524; GO:0048365; GO:0030036; GO:0004683; GO:0043197; GO:0097062; GO:0006020; GO:0008440; GO:0061003; GO:0048167 "ATP binding; Rac GTPase binding; actin cytoskeleton organization; calmodulin-dependent protein kinase activity; dendritic spine; dendritic spine maintenance; inositol metabolic process; inositol-1,4,5-trisphosphate 3-kinase activity; positive regulation of dendritic spine morphogenesis; regulation of synaptic plasticity" IPR005522; "Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A)" Itpka Rattus norvegicus (Rat) TR36230_c7_g4_i1 P42335 IP3KB_RAT 2.00E-27 GO:0005524; GO:0008440 "ATP binding; inositol-1,4,5-trisphosphate 3-kinase activity" IPR005522; "Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B)" Itpkb Rattus norvegicus (Rat) TR36231_c2_g1_i1 Q9ULU4 PKCB1_HUMAN 3.00E-35 GO:0001106; GO:0005634; GO:0070491; GO:0008270 P41182 RNA polymerase II transcription corepressor activity; nucleus; repressing transcription factor binding; zinc ion binding IPR001487; IPR021931; IPR000313; IPR019786; IPR011011; IPR002893; IPR001965; IPR019787; IPR013083; Protein kinase C-binding protein 1 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Rack7) (Zinc finger MYND domain-containing protein 8) ZMYND8 KIAA1125 PRKCBP1 RACK7 Homo sapiens (Human) TR36231_c2_g2_i1 Q9ULU4 PKCB1_HUMAN 3.00E-124 GO:0001106; GO:0005634; GO:0070491; GO:0008270 P41182 RNA polymerase II transcription corepressor activity; nucleus; repressing transcription factor binding; zinc ion binding IPR001487; IPR021931; IPR000313; IPR019786; IPR011011; IPR002893; IPR001965; IPR019787; IPR013083; Protein kinase C-binding protein 1 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Rack7) (Zinc finger MYND domain-containing protein 8) ZMYND8 KIAA1125 PRKCBP1 RACK7 Homo sapiens (Human) TR36231_c2_g2_i2 Q15326 ZMY11_HUMAN 1.00E-39 GO:0003677; GO:0007049; GO:0008283; GO:0016568; GO:0005694; GO:0005737; GO:0019048; GO:0043124; GO:0046329; GO:2001237; GO:0000122; GO:0005634; GO:0006351; GO:0008270 P03255; P12978; P03230; P36941; Q13114 "DNA binding; cell cycle; cell proliferation; chromatin modification; chromosome; cytoplasm; modulation by virus of host morphology or physiology; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of JNK cascade; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; zinc ion binding" IPR001487; IPR000313; IPR019786; IPR011011; IPR002893; IPR001965; IPR019787; IPR001841; IPR013083; Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Protein BS69) ZMYND11 BS69 Homo sapiens (Human) TR36231_c2_g2_i3 Q56R14 TRI33_XENLA 5.00E-11 GO:0003677; GO:0016874; GO:0005634; GO:0016567; GO:0006355; GO:0006351; GO:0008270 "DNA binding; ligase activity; nucleus; protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 ecto Xenopus laevis (African clawed frog) TR36231_c2_g2_i4 Q15326 ZMY11_HUMAN 1.00E-39 GO:0003677; GO:0007049; GO:0008283; GO:0016568; GO:0005694; GO:0005737; GO:0019048; GO:0043124; GO:0046329; GO:2001237; GO:0000122; GO:0005634; GO:0006351; GO:0008270 P03255; P12978; P03230; P36941; Q13114 "DNA binding; cell cycle; cell proliferation; chromatin modification; chromosome; cytoplasm; modulation by virus of host morphology or physiology; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of JNK cascade; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; zinc ion binding" IPR001487; IPR000313; IPR019786; IPR011011; IPR002893; IPR001965; IPR019787; IPR001841; IPR013083; Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Protein BS69) ZMYND11 BS69 Homo sapiens (Human) TR36231_c2_g2_i5 Q9ULU4 PKCB1_HUMAN 1.00E-124 GO:0001106; GO:0005634; GO:0070491; GO:0008270 P41182 RNA polymerase II transcription corepressor activity; nucleus; repressing transcription factor binding; zinc ion binding IPR001487; IPR021931; IPR000313; IPR019786; IPR011011; IPR002893; IPR001965; IPR019787; IPR013083; Protein kinase C-binding protein 1 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Rack7) (Zinc finger MYND domain-containing protein 8) ZMYND8 KIAA1125 PRKCBP1 RACK7 Homo sapiens (Human) TR36231_c3_g1_i1 Q5ZHN5 THAP5_CHICK 1.00E-06 GO:0003677; GO:0046872; GO:0005634 DNA binding; metal ion binding; nucleus IPR006612; THAP domain-containing protein 5 THAP5 RCJMB04_35c20 Gallus gallus (Chicken) TR36232_c1_g2_i1 Q02337 BDH_BOVIN 9.00E-66 GO:0003858; GO:0005743; GO:0005759 3-hydroxybutyrate dehydrogenase activity; mitochondrial inner membrane; mitochondrial matrix IPR002198; IPR002347; IPR016040; IPR020904; "D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase)" BDH1 BDH Bos taurus (Bovine) TR36233_c4_g2_i2 Q06507 ATF4_MOUSE 1.00E-12 GO:0003677; GO:0005737; GO:0032590; GO:0007214; GO:0006094; GO:0070059; GO:0005815; GO:0043267; GO:0005634; GO:0043525; GO:0045944; GO:0043565; GO:0003700; GO:0005667; GO:0006351 Q8K4K2 "DNA binding; cytoplasm; dendrite membrane; gamma-aminobutyric acid signaling pathway; gluconeogenesis; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; microtubule organizing center; negative regulation of potassium ion transport; nucleus; positive regulation of neuron apoptotic process; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent" IPR004827; Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (C/EBP-related ATF) (C/ATF) (Tax-responsive enhancer element-binding protein 67 homolog) (TaxREB67 homolog) Atf4 Mus musculus (Mouse) TR36234_c1_g2_i1 O44252 ROST_DROME 1.00E-22 GO:0016021; GO:0016020; GO:0007520; GO:0007519 integral to membrane; membrane; myoblast fusion; skeletal muscle tissue development IPR006838; Protein rolling stone rost CG9552 Drosophila melanogaster (Fruit fly) TR36234_c1_g2_i4 O44252 ROST_DROME 6.00E-24 GO:0016021; GO:0016020; GO:0007520; GO:0007519 integral to membrane; membrane; myoblast fusion; skeletal muscle tissue development IPR006838; Protein rolling stone rost CG9552 Drosophila melanogaster (Fruit fly) TR36235_c1_g2_i10 Q6DHC1 RB18B_DANRE 1.00E-103 GO:0005525; GO:0007420; GO:0009790; GO:0001654; GO:0015031; GO:0007264 GTP binding; brain development; embryo development; eye development; protein transport; small GTPase mediated signal transduction IPR027417; IPR025662; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-18-B rab18b rab18 zgc:92523 Danio rerio (Zebrafish) (Brachydanio rerio) TR36235_c1_g2_i11 Q6DHC1 RB18B_DANRE 2.00E-108 GO:0005525; GO:0007420; GO:0009790; GO:0001654; GO:0015031; GO:0007264 GTP binding; brain development; embryo development; eye development; protein transport; small GTPase mediated signal transduction IPR027417; IPR025662; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-18-B rab18b rab18 zgc:92523 Danio rerio (Zebrafish) (Brachydanio rerio) TR36235_c1_g2_i4 P49103 RAB2A_MAIZE 4.00E-43 GO:0005525; GO:0033116; GO:0015031; GO:0007264 GTP binding; endoplasmic reticulum-Golgi intermediate compartment membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-2-A RAB2A Zea mays (Maize) TR36235_c1_g2_i5 Q6DHC1 RB18B_DANRE 6.00E-110 GO:0005525; GO:0007420; GO:0009790; GO:0001654; GO:0015031; GO:0007264 GTP binding; brain development; embryo development; eye development; protein transport; small GTPase mediated signal transduction IPR027417; IPR025662; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-18-B rab18b rab18 zgc:92523 Danio rerio (Zebrafish) (Brachydanio rerio) TR36235_c1_g2_i7 P49103 RAB2A_MAIZE 6.00E-42 GO:0005525; GO:0033116; GO:0015031; GO:0007264 GTP binding; endoplasmic reticulum-Golgi intermediate compartment membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-2-A RAB2A Zea mays (Maize) TR36235_c1_g2_i8 P35293 RAB18_MOUSE 1.00E-104 GO:0019003; GO:0005525; GO:0016324; GO:0009925; GO:0007420; GO:0001654; GO:0005622; GO:0015031; GO:0007264 GDP binding; GTP binding; apical plasma membrane; basal plasma membrane; brain development; eye development; intracellular; protein transport; small GTPase mediated signal transduction IPR027417; IPR025662; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-18 Rab18 Mus musculus (Mouse) TR36238_c1_g1_i1 Q8VYF5 AGUB_ARATH 2.00E-27 GO:0050126; GO:0009446; GO:0033388 N-carbamoylputrescine amidase activity; putrescine biosynthetic process; putrescine biosynthetic process from arginine IPR003010; IPR017755; Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from N-carbamoylputrescine (amidase route): step 1/1. N-carbamoylputrescine amidase (EC 3.5.1.53) (Nitrilase-like protein 1) CPA NLP1 At2g27450 F10A12.13 Arabidopsis thaliana (Mouse-ear cress) TR36238_c1_g1_i2 O59829 YCU9_SCHPO 2.00E-16 GO:0005829; GO:0016810; GO:0006807; GO:0005634 "cytosol; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; nitrogen compound metabolic process; nucleus" IPR003010; Probable nitrilase C965.09 (EC 3.5.-.-) SPCC965.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36238_c1_g1_i3 Q9UBR1 BUP1_HUMAN 0 GO:0019483; GO:0003837; GO:0005829; GO:0046872; GO:0006206; GO:0046135 beta-alanine biosynthetic process; beta-ureidopropionase activity; cytosol; metal ion binding; pyrimidine nucleobase metabolic process; pyrimidine nucleoside catabolic process IPR003010; Amino-acid biosynthesis; beta-alanine biosynthesis. Beta-ureidopropionase (EC 3.5.1.6) (BUP-1) (Beta-alanine synthase) (N-carbamoyl-beta-alanine amidohydrolase) UPB1 BUP1 Homo sapiens (Human) TR36238_c1_g1_i4 Q44185 DCAS_RHIRD 3.00E-11 GO:0047417; GO:0006807 N-carbamoyl-D-amino acid hydrolase activity; nitrogen compound metabolic process IPR003010; N-carbamoyl-D-amino acid hydrolase (EC 3.5.1.77) (D-N-alpha-carbamilase) Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter) TR36239_c0_g1_i1 Q9UPX8 SHAN2_HUMAN 3.00E-17 GO:0030160; GO:0016324; GO:0031526; GO:0030054; GO:0060170; GO:0005737; GO:0043197; GO:0030426; GO:0035556; GO:0035255; GO:0043025; GO:0001917; GO:0001750; GO:0014069; GO:0045211 P46108; P62993; P16333; P27986; P19174 GKAP/Homer scaffold activity; apical plasma membrane; brush border membrane; cell junction; cilium membrane; cytoplasm; dendritic spine; growth cone; intracellular signal transduction; ionotropic glutamate receptor binding; neuronal cell body; photoreceptor inner segment; photoreceptor outer segment; postsynaptic density; postsynaptic membrane IPR001478; IPR001660; IPR013761; IPR021129; IPR011511; IPR001452; SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1) SHANK2 CORTBP1 KIAA1022 PROSAP1 Homo sapiens (Human) TR36239_c1_g1_i2 P35221 CTNA1_HUMAN 3.00E-23 GO:0001669; GO:0015629; GO:0034332; GO:0007568; GO:0043297; GO:0031103; GO:0016342; GO:0007155; GO:0005911; GO:0071681; GO:0005829; GO:0007163; GO:0016264; GO:0014704; GO:0030027; GO:0008584; GO:0042692; GO:0043066; GO:0007406; GO:0042475; GO:0001541; GO:0051149; GO:0045880; GO:0051291; GO:0043627; GO:0005198; GO:0005915 acrosomal vesicle; actin cytoskeleton; adherens junction organization; aging; apical junction assembly; axon regeneration; catenin complex; cell adhesion; cell-cell junction; cellular response to indole-3-methanol; cytosol; establishment or maintenance of cell polarity; gap junction assembly; intercalated disc; lamellipodium; male gonad development; muscle cell differentiation; negative regulation of apoptotic process; negative regulation of neuroblast proliferation; odontogenesis of dentin-containing tooth; ovarian follicle development; positive regulation of muscle cell differentiation; positive regulation of smoothened signaling pathway; protein heterooligomerization; response to estrogen stimulus; structural molecule activity; zonula adherens IPR001033; IPR006077; IPR000633; Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) CTNNA1 Homo sapiens (Human) TR36239_c1_g1_i3 Q5RC06 CTNL1_PONAB 2.00E-92 GO:0015629; GO:0007155; GO:0005938; GO:0005198 actin cytoskeleton; cell adhesion; cell cortex; structural molecule activity IPR001033; IPR006077; Alpha-catulin (Alpha-catenin-related protein) (ACRP) (Catenin alpha-like protein 1) CTNNAL1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36239_c1_g1_i4 Q5RC06 CTNL1_PONAB 3.00E-92 GO:0015629; GO:0007155; GO:0005938; GO:0005198 actin cytoskeleton; cell adhesion; cell cortex; structural molecule activity IPR001033; IPR006077; Alpha-catulin (Alpha-catenin-related protein) (ACRP) (Catenin alpha-like protein 1) CTNNAL1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36240_c0_g1_i1 P83425 HIP_MYTED 2.00E-11 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR36243_c0_g1_i1 Q8VHE0 SEC63_MOUSE 1.00E-152 GO:0006614; GO:0005789; GO:0016021; GO:0001889; GO:0016020; GO:0010259; GO:0006807; GO:0006620; GO:0031204; GO:0008565; GO:0072001 "SRP-dependent cotranslational protein targeting to membrane; endoplasmic reticulum membrane; integral to membrane; liver development; membrane; multicellular organismal aging; nitrogen compound metabolic process; posttranslational protein targeting to membrane; posttranslational protein targeting to membrane, translocation; protein transporter activity; renal system development" IPR001623; IPR014756; IPR027137; IPR004179; Translocation protein SEC63 homolog Sec63 Sec63l Mus musculus (Mouse) TR36245_c2_g1_i2 A3KPA3 NAA60_DANRE 1.00E-86 GO:0000139; GO:0010485; GO:0017196; GO:0008283; GO:0007059; GO:0006334; GO:0004596 Golgi membrane; H4 histone acetyltransferase activity; N-terminal peptidyl-methionine acetylation; cell proliferation; chromosome segregation; nucleosome assembly; peptide alpha-N-acetyltransferase activity IPR016181; IPR000182; N-alpha-acetyltransferase 60 (EC 2.3.1.48) (EC 2.3.1.88) (N-acetyltransferase 15) (NatF catalytic subunit) naa60 nat15 zgc:163109 Danio rerio (Zebrafish) (Brachydanio rerio) TR36246_c0_g1_i7 Q0V882 BI1_BOVIN 2.00E-42 GO:0006915; GO:0005789; GO:0016021; GO:0043066; GO:0006986 apoptotic process; endoplasmic reticulum membrane; integral to membrane; negative regulation of apoptotic process; response to unfolded protein IPR006213; IPR006214; Bax inhibitor 1 (BI-1) (Testis-enhanced gene transcript protein) (Transmembrane BAX inhibitor motif-containing protein 6) TMBIM6 TEGT Bos taurus (Bovine) TR36246_c1_g1_i1 Q5ZKH6 HDAC9_CHICK 1.00E-21 GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0007507; GO:0070932; GO:0070933; GO:0035097; GO:0000122; GO:0048742; GO:0003714; GO:0006351 "NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); heart development; histone H3 deacetylation; histone H4 deacetylation; histone methyltransferase complex; negative regulation of transcription from RNA polymerase II promoter; regulation of skeletal muscle fiber development; transcription corepressor activity; transcription, DNA-dependent" IPR000286; IPR024643; Histone deacetylase 9 (EC 3.5.1.98) hdac9 RCJMB04_10m2 Gallus gallus (Chicken) TR36246_c1_g1_i2 P83038 HDAC4_CHICK 0 GO:0030183; GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0070932; GO:0070933; GO:0004407; GO:0000118; GO:0006954; GO:0046872; GO:0045843; GO:0045892; GO:0007399; GO:0008134; GO:0006351 "B cell differentiation; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone H3 deacetylation; histone H4 deacetylation; histone deacetylase activity; histone deacetylase complex; inflammatory response; metal ion binding; negative regulation of striated muscle tissue development; negative regulation of transcription, DNA-dependent; nervous system development; transcription factor binding; transcription, DNA-dependent" IPR000286; IPR023801; IPR024643; IPR017320; Histone deacetylase 4 (HD4) (EC 3.5.1.98) HDAC4 Gallus gallus (Chicken) TR36247_c0_g1_i1 Q9BQG0 MBB1A_HUMAN 9.00E-29 GO:0003887; GO:0042564; GO:0042149; GO:0005737; GO:0072332; GO:0045892; GO:0006913; GO:0005730; GO:0071158; GO:0006355; GO:0022904; GO:0043565; GO:0008134; GO:0006351 Q7L2E3; Q9Y5X4 "DNA-directed DNA polymerase activity; NLS-dependent protein nuclear import complex; cellular response to glucose starvation; cytoplasm; intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of transcription, DNA-dependent; nucleocytoplasmic transport; nucleolus; positive regulation of cell cycle arrest; regulation of transcription, DNA-dependent; respiratory electron transport chain; sequence-specific DNA binding; transcription factor binding; transcription, DNA-dependent" IPR016024; IPR007015; Myb-binding protein 1A MYBBP1A P160 Homo sapiens (Human) TR36247_c0_g1_i3 Q6DRL5 MBB1A_DANRE 2.00E-15 GO:0003677; GO:0003887; GO:0005730; GO:0006355; GO:0006351 "DNA binding; DNA-directed DNA polymerase activity; nucleolus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011989; IPR016024; IPR007015; Myb-binding protein 1A-like protein mybbp1a Danio rerio (Zebrafish) (Brachydanio rerio) TR36249_c0_g3_i1 P51570 GALK1_HUMAN 2.00E-123 GO:0005524; GO:0005829; GO:0019402; GO:0004335; GO:0005534; GO:0019388; GO:0044281 ATP binding; cytosol; galactitol metabolic process; galactokinase activity; galactose binding; galactose catabolic process; small molecule metabolic process IPR000705; IPR019741; IPR019539; IPR013750; IPR006204; IPR006203; IPR006206; IPR020568; IPR014721; Carbohydrate metabolism; galactose metabolism. Galactokinase (EC 2.7.1.6) (Galactose kinase) GALK1 GALK Homo sapiens (Human) TR36249_c0_g3_i2 Q01415 GALK2_HUMAN 4.00E-10 GO:0005524; GO:0033858; GO:0005737; GO:0004335; GO:0006012 ATP binding; N-acetylgalactosamine kinase activity; cytoplasm; galactokinase activity; galactose metabolic process IPR000705; IPR019741; IPR019539; IPR013750; IPR006204; IPR006203; IPR006206; IPR020568; IPR014721; N-acetylgalactosamine kinase (EC 2.7.1.157) (GalNAc kinase) (Galactokinase 2) GALK2 GK2 Homo sapiens (Human) TR36251_c0_g2_i1 P0CH10 RL403_CHLRE 2.00E-36 GO:0005634; GO:0005840; GO:0003735; GO:0006412 nucleus; ribosome; structural constituent of ribosome; translation IPR001975; IPR019956; IPR019954; IPR000626; Ubiquitin-60S ribosomal protein L40 [Cleaved into: Ubiquitin; 60S ribosomal protein L40 (CEP52)] UBI3 Chlamydomonas reinhardtii (Chlamydomonas smithii) TR36253_c2_g1_i1 Q9YHB5 CND3_XENLA 4.00E-70 GO:0051301; GO:0000796; GO:0005829; GO:0007076; GO:0005634 cell division; condensin complex; cytosol; mitotic chromosome condensation; nucleus IPR011989; IPR016024; IPR027165; IPR025977; Condensin complex subunit 3 (Chromosome assembly protein xCAP-G) (Chromosome-associated protein G) (Condensin subunit CAP-G) (Non-SMC condensin I complex subunit G) ncapg capg Xenopus laevis (African clawed frog) TR36254_c3_g1_i1 Q9NRH2 SNRK_HUMAN 0 GO:0005524; GO:0000287; GO:0030099; GO:0005634; GO:0004674 ATP binding; magnesium ion binding; myeloid cell differentiation; nucleus; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR015940; SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) SNRK KIAA0096 SNFRK Homo sapiens (Human) TR36254_c5_g1_i2 Q5ZLX5 ZRAB2_CHICK 1.00E-48 GO:0003723; GO:0005634; GO:0008270 RNA binding; nucleus; zinc ion binding IPR017337; IPR001876; Zinc finger Ran-binding domain-containing protein 2 ZRANB2 RCJMB04_4i6 Gallus gallus (Chicken) TR36255_c0_g1_i3 Q9N121 GCSH_RABIT 2.00E-42 GO:0005960; GO:0019464; GO:0005739 glycine cleavage complex; glycine decarboxylation via glycine cleavage system; mitochondrion IPR003016; IPR002930; IPR017453; IPR011053; "Glycine cleavage system H protein, mitochondrial" GCSH Oryctolagus cuniculus (Rabbit) TR36256_c3_g3_i1 Q8K3C3 LZIC_MOUSE 1.00E-63 GO:0007417; GO:0010212 central nervous system development; response to ionizing radiation IPR009428; Protein LZIC (Leucine zipper and CTNNBIP1 domain-containing protein) (Leucine zipper and ICAT homologous domain-containing protein) Lzic Mus musculus (Mouse) TR36256_c3_g3_i2 Q8K3C3 LZIC_MOUSE 1.00E-63 GO:0007417; GO:0010212 central nervous system development; response to ionizing radiation IPR009428; Protein LZIC (Leucine zipper and CTNNBIP1 domain-containing protein) (Leucine zipper and ICAT homologous domain-containing protein) Lzic Mus musculus (Mouse) TR36257_c2_g1_i1 O16025 AOSL_PLEHO 1.00E-46 GO:0047677; GO:0019369; GO:0004096; GO:0005737; GO:0020037; GO:0047987; GO:0005506; GO:0016020; GO:0031408 arachidonate 8(R)-lipoxygenase activity; arachidonic acid metabolic process; catalase activity; cytoplasm; heme binding; hydroperoxide dehydratase activity; iron ion binding; membrane; oxylipin biosynthetic process IPR020835; IPR011614; IPR008976; IPR000907; IPR013819; IPR020834; IPR020833; IPR001885; IPR001024; Lipid metabolism; arachidonate metabolism. Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (EC 4.2.1.92) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)] Plexaura homomalla (Black sea rod) TR36258_c0_g1_i4 Q7TSY2 LHPL4_RAT 1.00E-49 GO:0016021 integral to membrane IPR019372; Lipoma HMGIC fusion partner-like protein 4 Lhfpl4 Rattus norvegicus (Rat) TR36259_c0_g1_i1 P25067 CO8A2_HUMAN 3.00E-06 GO:0001525; GO:0005604; GO:0048593; GO:0016337; GO:0005581; GO:0030574; GO:0005788; GO:0050673; GO:0022617; GO:0005201; GO:0030674 "angiogenesis; basement membrane; camera-type eye morphogenesis; cell-cell adhesion; collagen; collagen catabolic process; endoplasmic reticulum lumen; epithelial cell proliferation; extracellular matrix disassembly; extracellular matrix structural constituent; protein binding, bridging" IPR001073; IPR008160; IPR008983; Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) TR36260_c2_g1_i1 Q9Y345 SC6A5_HUMAN 3.00E-100 GO:0015375; GO:0016021; GO:0005328; GO:0005886; GO:0007268 glycine:sodium symporter activity; integral to membrane; neurotransmitter:sodium symporter activity; plasma membrane; synaptic transmission IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) TR36260_c2_g2_i1 Q9H1V8 S6A17_HUMAN 8.00E-29 GO:0032328; GO:0030054; GO:0015816; GO:0005887; GO:0015820; GO:0005328; GO:0015824; GO:0008021; GO:0030672 alanine transport; cell junction; glycine transport; integral to plasma membrane; leucine transport; neurotransmitter:sodium symporter activity; proline transport; synaptic vesicle; synaptic vesicle membrane IPR000175; IPR002438; Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17) SLC6A17 NTT4 Homo sapiens (Human) TR36263_c1_g1_i1 Q68F38 VAC14_XENLA 8.00E-27 GO:0010008; GO:0019209 endosome membrane; kinase activator activity IPR011989; IPR016024; IPR026825; IPR021841; Protein VAC14 homolog vac14 Xenopus laevis (African clawed frog) TR36263_c10_g2_i1 P87145 VAC14_SCHPO 1.00E-24 GO:0000329; GO:0019209; GO:0046488; GO:0048015; GO:0043234; GO:0000011 fungal-type vacuole membrane; kinase activator activity; phosphatidylinositol metabolic process; phosphatidylinositol-mediated signaling; protein complex; vacuole inheritance IPR011989; IPR016024; IPR026825; IPR021841; Protein VAC14 homolog SPBC25H2.03 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36263_c11_g3_i1 A5PMU4 ANS1B_DANRE 1.00E-06 GO:0005737 cytoplasm IPR002110; IPR020683; IPR011993; IPR006020; IPR001660; IPR013761; IPR011510; IPR021129; Ankyrin repeat and sterile alpha motif domain-containing protein 1B anks1b si:ch211-211o1.2 si:dkey-11k24.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR36263_c11_g3_i2 A2AS55 ANR16_MOUSE 7.00E-06 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 16 Ankrd16 Mus musculus (Mouse) TR36263_c11_g3_i3 Q53LP3 SWAHC_HUMAN 8.00E-30 IPR002110; IPR020683; Ankyrin repeat domain-containing protein SOWAHC (Ankyrin repeat domain-containing protein 57) (Protein sosondowah homolog C) SOWAHC ANKRD57 C2orf26 Homo sapiens (Human) TR36263_c8_g1_i1 Q08AM6 VAC14_HUMAN 2.00E-73 GO:0000139; GO:0031901; GO:0005783; GO:0019209; GO:0031902; GO:0019048; GO:0006661; GO:0004872; GO:0007165; GO:0044281 P29475 Golgi membrane; early endosome membrane; endoplasmic reticulum; kinase activator activity; late endosome membrane; modulation by virus of host morphology or physiology; phosphatidylinositol biosynthetic process; receptor activity; signal transduction; small molecule metabolic process IPR011989; IPR016024; IPR026825; IPR021841; Protein VAC14 homolog (Tax1-binding protein 2) VAC14 TAX1BP2 TRX Homo sapiens (Human) TR36265_c2_g4_i1 Q8VC26 TLCD2_MOUSE 3.00E-12 GO:0016021 integral to membrane IPR006634; TLC domain-containing protein 2 Tlcd2 Mus musculus (Mouse) TR36265_c2_g4_i3 A6NGC4 TLCD2_HUMAN 9.00E-11 GO:0016021 integral to membrane IPR006634; TLC domain-containing protein 2 TLCD2 Homo sapiens (Human) TR36265_c2_g4_i4 A8WGS4 TLCD2_DANRE 8.00E-26 GO:0016021 integral to membrane IPR006634; TLC domain-containing protein 2 tlcd2 zgc:175098 Danio rerio (Zebrafish) (Brachydanio rerio) TR36267_c1_g1_i1 Q9V564 COG6_DROME 2.00E-165 GO:0000139; GO:0017119; GO:0006891; GO:0015031 Golgi membrane; Golgi transport complex; intra-Golgi vesicle-mediated transport; protein transport IPR010490; Conserved oligomeric Golgi complex subunit 6 (COG complex subunit 6) (Component of oligomeric Golgi complex 6) CG1968 Drosophila melanogaster (Fruit fly) TR36267_c1_g1_i2 Q9Y2V7 COG6_HUMAN 0 GO:0000139; GO:0017119; GO:0070085; GO:0006891; GO:0015031 Golgi membrane; Golgi transport complex; glycosylation; intra-Golgi vesicle-mediated transport; protein transport IPR010490; Conserved oligomeric Golgi complex subunit 6 (COG complex subunit 6) (Component of oligomeric Golgi complex 6) COG6 KIAA1134 Homo sapiens (Human) TR36267_c1_g1_i3 Q0UYL3 COG6_PHANO 4.00E-80 GO:0000139; GO:0017119; GO:0006891; GO:0015031 Golgi membrane; Golgi transport complex; intra-Golgi vesicle-mediated transport; protein transport IPR010490; Conserved oligomeric Golgi complex subunit 6 (COG complex subunit 6) (Component of oligomeric Golgi complex 6) COG6 SNOG_03151 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum) TR36267_c1_g1_i5 A4QUK5 COG6_MAGO7 3.00E-52 GO:0000139; GO:0017119; GO:0006891; GO:0015031 Golgi membrane; Golgi transport complex; intra-Golgi vesicle-mediated transport; protein transport IPR010490; Conserved oligomeric Golgi complex subunit 6 (COG complex subunit 6) (Component of oligomeric Golgi complex 6) COG6 MGG_09558 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) TR36268_c2_g1_i2 Q9CR23 TMEM9_MOUSE 8.00E-16 GO:0016021; GO:0005770; GO:0031902; GO:0005765; GO:0005764; GO:0006810 integral to membrane; late endosome; late endosome membrane; lysosomal membrane; lysosome; transport IPR008853; Transmembrane protein 9 Tmem9 Mus musculus (Mouse) TR36270_c1_g1_i2 Q9NNX6 CD209_HUMAN 5.00E-06 GO:0009988; GO:0005737; GO:0006897; GO:0005576; GO:0007157; GO:0045087; GO:0016021; GO:0035556; GO:0046795; GO:0007159; GO:0005537; GO:0016020; GO:0046872; GO:0019048; GO:0042605; GO:0046968; GO:0005886; GO:0042129; GO:0019062; GO:0019079; GO:0046790 cell-cell recognition; cytoplasm; endocytosis; extracellular region; heterophilic cell-cell adhesion; innate immune response; integral to membrane; intracellular signal transduction; intracellular virion transport; leukocyte cell-cell adhesion; mannose binding; membrane; metal ion binding; modulation by virus of host morphology or physiology; peptide antigen binding; peptide antigen transport; plasma membrane; regulation of T cell proliferation; viral attachment to host cell; viral genome replication; virion binding IPR001304; IPR016186; IPR018378; IPR016187; CD209 antigen (C-type lectin domain family 4 member L) (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN) (DC-SIGN1) (CD antigen CD209) CD209 CLEC4L Homo sapiens (Human) TR36270_c1_g1_i3 Q9QZ15 CLC4A_MOUSE 6.00E-06 GO:0030246; GO:0045087; GO:0016021; GO:0016020 carbohydrate binding; innate immune response; integral to membrane; membrane IPR001304; IPR016186; IPR018378; IPR016187; C-type lectin domain family 4 member A (C-type lectin superfamily member 6) (Dendritic cell immunoreceptor) Clec4a Clec4a2 Clecsf6 Dcir Mus musculus (Mouse) TR36271_c0_g2_i2 O60869 EDF1_HUMAN 8.00E-58 GO:0005737; GO:0045446; GO:0007275; GO:0005730; GO:0005634; GO:0043388; GO:0045893; GO:0019216; GO:0043565; GO:0003713; GO:0006351 Q13133; Q04752; O00482; P37231; P20226 "cytoplasm; endothelial cell differentiation; multicellular organismal development; nucleolus; nucleus; positive regulation of DNA binding; positive regulation of transcription, DNA-dependent; regulation of lipid metabolic process; sequence-specific DNA binding; transcription coactivator activity; transcription, DNA-dependent" IPR001387; IPR010982; IPR013729; Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1) EDF1 Homo sapiens (Human) TR36271_c0_g2_i4 O60869 EDF1_HUMAN 8.00E-59 GO:0005737; GO:0045446; GO:0007275; GO:0005730; GO:0005634; GO:0043388; GO:0045893; GO:0019216; GO:0043565; GO:0003713; GO:0006351 Q13133; Q04752; O00482; P37231; P20226 "cytoplasm; endothelial cell differentiation; multicellular organismal development; nucleolus; nucleus; positive regulation of DNA binding; positive regulation of transcription, DNA-dependent; regulation of lipid metabolic process; sequence-specific DNA binding; transcription coactivator activity; transcription, DNA-dependent" IPR001387; IPR010982; IPR013729; Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1) EDF1 Homo sapiens (Human) TR36273_c0_g1_i1 Q9C1K6 PDX1_NEUCR 7.00E-119 GO:0003824; GO:0042823; GO:0008615 catalytic activity; pyridoxal phosphate biosynthetic process; pyridoxine biosynthetic process IPR013785; IPR011060; IPR001852; Probable pyridoxine biosynthesis protein pdx-1 pdx-1 NCU06550 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR36273_c0_g1_i2 A0QWG8 PDXS_MYCS2 1.00E-125 GO:0016829; GO:0042823 lyase activity; pyridoxal phosphate biosynthetic process IPR013785; IPR011060; IPR001852; Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis. Pyridoxal biosynthesis lyase PdxS (EC 4.-.-.-) pdxS MSMEG_2937 MSMEI_2863 Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) TR36273_c0_g1_i4 Q5SKD9 PDXS_THET8 4.00E-140 GO:0016829; GO:0042823 lyase activity; pyridoxal phosphate biosynthetic process IPR013785; IPR011060; IPR001852; Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis. Pyridoxal biosynthesis lyase PdxS (EC 4.-.-.-) pdxS TTHA0704 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) TR36273_c0_g1_i5 Q8WPW2 PDX1_SUBDO 6.00E-155 GO:0003824; GO:0042823; GO:0008615 catalytic activity; pyridoxal phosphate biosynthetic process; pyridoxine biosynthetic process IPR013785; IPR011060; IPR001852; Probable pyridoxine biosynthesis SNZERR (Ethylene response protein) (PDX1 homolog) SNZERR ERR Suberites domuncula (Sponge) TR36275_c0_g1_i1 P07306 ASGR1_HUMAN 5.00E-17 GO:0004873; GO:0030246; GO:0031668; GO:0005576; GO:0005887; GO:0046872 Q96G23 asialoglycoprotein receptor activity; carbohydrate binding; cellular response to extracellular stimulus; extracellular region; integral to plasma membrane; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; IPR005640; Asialoglycoprotein receptor 1 (ASGP-R 1) (ASGPR 1) (C-type lectin domain family 4 member H1) (Hepatic lectin H1) (HL-1) ASGR1 CLEC4H1 Homo sapiens (Human) TR36275_c0_g1_i2 P49300 CLC10_MOUSE 3.00E-21 GO:0030246; GO:0016021 carbohydrate binding; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR005640; C-type lectin domain family 10 member A (MMGL) (Macrophage asialoglycoprotein-binding protein 1) (M-ASGP-BP-1) (Macrophage galactose/N-acetylgalactosamine-specific lectin) Clec10a Mgl Mgl1 Mus musculus (Mouse) TR36275_c0_g1_i3 Q28062 PGCB_BOVIN 2.00E-20 GO:0030246; GO:0007155; GO:0005540; GO:0005578 carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR007110; IPR013783; IPR003006; IPR013106; IPR003596; IPR000538; IPR000436; Brevican core protein BCAN Bos taurus (Bovine) TR36275_c0_g1_i4 P49301 CLC10_RAT 7.00E-21 GO:0030246; GO:0016021 carbohydrate binding; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR005640; C-type lectin domain family 10 member A (MMGL) (Macrophage asialoglycoprotein-binding protein 1) (M-ASGP-BP-1) (Macrophage galactose/N-acetylgalactosamine-specific lectin) Clec10a Mgl Mgl1 Rattus norvegicus (Rat) TR36277_c0_g1_i1 A8E5V9 TM173_XENTR 4.00E-08 GO:0002218; GO:0006915; GO:0061507; GO:0035438; GO:0051607; GO:0005789; GO:0045087; GO:0016021; GO:0032608; GO:0005741; GO:0048471; GO:0005886; GO:0042803 activation of innate immune response; apoptotic process; cyclic-GMP-AMP binding; cyclic-di-GMP binding; defense response to virus; endoplasmic reticulum membrane; innate immune response; integral to membrane; interferon-beta production; mitochondrial outer membrane; perinuclear region of cytoplasm; plasma membrane; protein homodimerization activity Stimulator of interferon genes protein (STING) (Transmembrane protein 173) tmem173 sting Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36277_c2_g1_i2 Q3TBT3 TM173_MOUSE 3.00E-07 GO:0005794; GO:0002218; GO:0006915; GO:0071360; GO:0035458; GO:0061507; GO:0035438; GO:0051607; GO:0005789; GO:0045087; GO:0016021; GO:0032608; GO:0005741; GO:0048471; GO:0005777; GO:0005886; GO:0002230; GO:0032092; GO:0033160; GO:0042993; GO:0045944; GO:0042803 Q91VN6; Q9WUN2 "Golgi apparatus; activation of innate immune response; apoptotic process; cellular response to exogenous dsRNA; cellular response to interferon-beta; cyclic-GMP-AMP binding; cyclic-di-GMP binding; defense response to virus; endoplasmic reticulum membrane; innate immune response; integral to membrane; interferon-beta production; mitochondrial outer membrane; perinuclear region of cytoplasm; peroxisome; plasma membrane; positive regulation of defense response to virus by host; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; protein homodimerization activity" Stimulator of interferon genes protein (mSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (MMITA) (Transmembrane protein 173) Tmem173 Eris Mita Mpys Sting Mus musculus (Mouse) TR36277_c2_g1_i4 Q86WV6 TM173_HUMAN 2.00E-07 GO:0005794; GO:0002218; GO:0006915; GO:0071360; GO:0035458; GO:0061507; GO:0035438; GO:0030659; GO:0051607; GO:0005789; GO:0045087; GO:0016021; GO:0032608; GO:0005741; GO:0048471; GO:0005777; GO:0005886; GO:0002230; GO:0032092; GO:0033160; GO:0042993; GO:0045944; GO:0032481; GO:0042803; GO:0019901; GO:0008134 Itself; P27958; Q99IB8; Q96A33; P39656; Q16666; P51617; O94822; Q7Z434; Q96N66; O95470; P42226; P46977; O15260; Q9UHD2 "Golgi apparatus; activation of innate immune response; apoptotic process; cellular response to exogenous dsRNA; cellular response to interferon-beta; cyclic-GMP-AMP binding; cyclic-di-GMP binding; cytoplasmic vesicle membrane; defense response to virus; endoplasmic reticulum membrane; innate immune response; integral to membrane; interferon-beta production; mitochondrial outer membrane; perinuclear region of cytoplasm; peroxisome; plasma membrane; positive regulation of defense response to virus by host; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of type I interferon production; protein homodimerization activity; protein kinase binding; transcription factor binding" Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173) TMEM173 ERIS MITA STING Homo sapiens (Human) TR36277_c3_g2_i1 A8E5V9 TM173_XENTR 1.00E-12 GO:0002218; GO:0006915; GO:0061507; GO:0035438; GO:0051607; GO:0005789; GO:0045087; GO:0016021; GO:0032608; GO:0005741; GO:0048471; GO:0005886; GO:0042803 activation of innate immune response; apoptotic process; cyclic-GMP-AMP binding; cyclic-di-GMP binding; defense response to virus; endoplasmic reticulum membrane; innate immune response; integral to membrane; interferon-beta production; mitochondrial outer membrane; perinuclear region of cytoplasm; plasma membrane; protein homodimerization activity Stimulator of interferon genes protein (STING) (Transmembrane protein 173) tmem173 sting Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36277_c3_g2_i5 Q2KI99 TM173_BOVIN 6.00E-06 GO:0005794; GO:0002218; GO:0006915; GO:0071360; GO:0035458; GO:0061507; GO:0035438; GO:0051607; GO:0005789; GO:0045087; GO:0016021; GO:0032608; GO:0005741; GO:0048471; GO:0005777; GO:0005886; GO:0002230; GO:0032092; GO:0033160; GO:0042993; GO:0045944; GO:0042803 "Golgi apparatus; activation of innate immune response; apoptotic process; cellular response to exogenous dsRNA; cellular response to interferon-beta; cyclic-GMP-AMP binding; cyclic-di-GMP binding; defense response to virus; endoplasmic reticulum membrane; innate immune response; integral to membrane; interferon-beta production; mitochondrial outer membrane; perinuclear region of cytoplasm; peroxisome; plasma membrane; positive regulation of defense response to virus by host; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; protein homodimerization activity" Stimulator of interferon genes protein (STING) (Transmembrane protein 173) TMEM173 STING Bos taurus (Bovine) TR36277_c3_g2_i6 Q86WV6 TM173_HUMAN 3.00E-13 GO:0005794; GO:0002218; GO:0006915; GO:0071360; GO:0035458; GO:0061507; GO:0035438; GO:0030659; GO:0051607; GO:0005789; GO:0045087; GO:0016021; GO:0032608; GO:0005741; GO:0048471; GO:0005777; GO:0005886; GO:0002230; GO:0032092; GO:0033160; GO:0042993; GO:0045944; GO:0032481; GO:0042803; GO:0019901; GO:0008134 Itself; P27958; Q99IB8; Q96A33; P39656; Q16666; P51617; O94822; Q7Z434; Q96N66; O95470; P42226; P46977; O15260; Q9UHD2 "Golgi apparatus; activation of innate immune response; apoptotic process; cellular response to exogenous dsRNA; cellular response to interferon-beta; cyclic-GMP-AMP binding; cyclic-di-GMP binding; cytoplasmic vesicle membrane; defense response to virus; endoplasmic reticulum membrane; innate immune response; integral to membrane; interferon-beta production; mitochondrial outer membrane; perinuclear region of cytoplasm; peroxisome; plasma membrane; positive regulation of defense response to virus by host; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of type I interferon production; protein homodimerization activity; protein kinase binding; transcription factor binding" Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173) TMEM173 ERIS MITA STING Homo sapiens (Human) TR36278_c0_g2_i1 Q13620 CUL4B_HUMAN 0 GO:0031465; GO:0006281; GO:0007049; GO:0005634; GO:0005886; GO:0045732; GO:0016567; GO:0006511 Q86VP6; Q16531; P62877 Cul4B-RING ubiquitin ligase complex; DNA repair; cell cycle; nucleus; plasma membrane; positive regulation of protein catabolic process; protein ubiquitination; ubiquitin-dependent protein catabolic process IPR016157; IPR016158; IPR001373; IPR019559; IPR016159; IPR011991; Protein modification; protein ubiquitination. Cullin-4B (CUL-4B) CUL4B KIAA0695 Homo sapiens (Human) TR36280_c5_g4_i3 B4QUC1 MOC2A_DROSI 6.00E-16 GO:0006777; GO:0005829; GO:0000166 Mo-molybdopterin cofactor biosynthetic process; cytosol; nucleotide binding IPR012675; IPR010034; IPR016155; IPR003749; Cofactor biosynthesis; molybdopterin biosynthesis. Molybdopterin synthase sulfur carrier subunit (Molybdenum cofactor synthesis protein 2 small subunit) (Molybdenum cofactor synthesis protein 2A) (MOCS2A) (Sulfur carrier protein MOCS2A) Mocs2 GD18231 Drosophila simulans (Fruit fly) TR36280_c5_g4_i4 B3M269 MOC2A_DROAN 4.00E-16 GO:0006777; GO:0005829; GO:0000166 Mo-molybdopterin cofactor biosynthetic process; cytosol; nucleotide binding IPR012675; IPR010034; IPR016155; IPR003749; Cofactor biosynthesis; molybdopterin biosynthesis. Molybdopterin synthase sulfur carrier subunit (Molybdenum cofactor synthesis protein 2 small subunit) (Molybdenum cofactor synthesis protein 2A) (MOCS2A) (Sulfur carrier protein MOCS2A) Mocs2 GF17097 Drosophila ananassae (Fruit fly) TR36280_c5_g4_i5 A4FUY7 MOC2B_BOVIN 2.00E-56 GO:0030366; GO:0005829; GO:0019008; GO:0005634; GO:0016740 Mo-molybdopterin synthase activity; cytosol; molybdopterin synthase complex; nucleus; transferase activity IPR003448; Cofactor biosynthesis; molybdopterin biosynthesis. Molybdopterin synthase catalytic subunit (EC 2.8.1.12) (Molybdenum cofactor synthesis protein 2 large subunit) (Molybdenum cofactor synthesis protein 2B) (MOCS2B) MOCS2 Bos taurus (Bovine) TR36281_c1_g1_i1 Q9QXW2 FBXW5_MOUSE 3.00E-84 GO:0080008; GO:0019005; GO:0031146; GO:0051298; GO:0005737; GO:0007067; GO:0016567 Cul4-RING ubiquitin ligase complex; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; centrosome duplication; cytoplasm; mitosis; protein ubiquitination IPR001810; IPR015943; IPR001680; IPR017986; Protein modification; protein ubiquitination. F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) Fbxw5 Fbw5 Mus musculus (Mouse) TR36283_c1_g1_i1 Q03206 RAC1_CAEEL 1.00E-38 GO:0005525; GO:0003924; GO:0006915; GO:0048846; GO:0031103; GO:0010171; GO:0009986; GO:0031410; GO:0005829; GO:0033563; GO:0043652; GO:0016021; GO:0009898; GO:0008045; GO:0002119; GO:0001764; GO:0030334; GO:0050764; GO:0007264 GTP binding; GTPase activity; apoptotic process; axon extension involved in axon guidance; axon regeneration; body morphogenesis; cell surface; cytoplasmic vesicle; cytosol; dorsal/ventral axon guidance; engulfment of apoptotic cell; integral to membrane; internal side of plasma membrane; motor neuron axon guidance; nematode larval development; neuron migration; regulation of cell migration; regulation of phagocytosis; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Ras-related protein ced-10 (CErac1) (Cell death protein 10) (Cell-corpse engulfment protein ced-10) (Ras-related protein rac-1) ced-10 rac-1 C09G12.8 Caenorhabditis elegans TR36283_c1_g1_i2 P34149 RACC_DICDI 3.00E-37 GO:0005525; GO:0031252; GO:0016477; GO:0006935; GO:0045184; GO:0005622; GO:0014065; GO:0005886; GO:0030838; GO:0019904; GO:0007264 GTP binding; cell leading edge; cell migration; chemotaxis; establishment of protein localization; intracellular; phosphatidylinositol 3-kinase cascade; plasma membrane; positive regulation of actin filament polymerization; protein domain specific binding; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Rho-related protein racC racC DDB_G0293526 Dictyostelium discoideum (Slime mold) TR36283_c1_g1_i3 Q03206 RAC1_CAEEL 1.00E-38 GO:0005525; GO:0003924; GO:0006915; GO:0048846; GO:0031103; GO:0010171; GO:0009986; GO:0031410; GO:0005829; GO:0033563; GO:0043652; GO:0016021; GO:0009898; GO:0008045; GO:0002119; GO:0001764; GO:0030334; GO:0050764; GO:0007264 GTP binding; GTPase activity; apoptotic process; axon extension involved in axon guidance; axon regeneration; body morphogenesis; cell surface; cytoplasmic vesicle; cytosol; dorsal/ventral axon guidance; engulfment of apoptotic cell; integral to membrane; internal side of plasma membrane; motor neuron axon guidance; nematode larval development; neuron migration; regulation of cell migration; regulation of phagocytosis; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Ras-related protein ced-10 (CErac1) (Cell death protein 10) (Cell-corpse engulfment protein ced-10) (Ras-related protein rac-1) ced-10 rac-1 C09G12.8 Caenorhabditis elegans TR36284_c1_g1_i2 Q29503 UB2R2_RABIT 1.00E-104 GO:0005524; GO:0070936; GO:0006513; GO:0004842 ATP binding; protein K48-linked ubiquitination; protein monoubiquitination; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin carrier protein R2) (Ubiquitin-conjugating enzyme E2-CDC34B) (Ubiquitin-protein ligase R2) UBE2R2 CDC34B Oryctolagus cuniculus (Rabbit) TR36285_c1_g1_i1 Q58DV5 RM30_BOVIN 7.00E-17 GO:0005739; GO:0005840 mitochondrion; ribosome IPR016082; "39S ribosomal protein L30, mitochondrial (L30mt) (MRP-L30)" MRPL30 Bos taurus (Bovine) TR36288_c4_g1_i2 Q08AY9 FA89A_XENLA 6.00E-11 IPR026654; Protein FAM89A fam89a Xenopus laevis (African clawed frog) TR36288_c4_g1_i3 A6QQF7 FA89A_BOVIN 1.00E-08 IPR026654; Protein FAM89A FAM89A Bos taurus (Bovine) TR36289_c0_g1_i1 Q8BTH6 SCRT2_MOUSE 7.00E-22 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Transcriptional repressor scratch 2 (Scratch homolog 2 zinc finger protein) Scrt2 Mus musculus (Mouse) TR36289_c0_g1_i2 Q14591 ZN271_HUMAN 2.00E-83 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 271 (CT-ZFP48) (Epstein-Barr virus-induced zinc finger protein) (EBV-induced zinc finger protein) (ZNF-EB) (Zinc finger protein HZF7) (Zinc finger protein ZNFphex133) (Zinc finger protein dp) (ZNF-dp) ZNF271 ZNFEB Homo sapiens (Human) TR36289_c0_g1_i3 O75437 ZN254_HUMAN 5.00E-80 GO:0003677; GO:0046872; GO:0000122; GO:0005634; GO:0006351 "DNA binding; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 254 (Bone marrow zinc finger 5) (BMZF-5) (Hematopoietic cell-derived zinc finger protein 1) (HD-ZNF1) (Zinc finger protein 539) (Zinc finger protein 91-like) ZNF254 BMZF5 ZNF539 ZNF91L Homo sapiens (Human) TR36290_c0_g1_i1 P48601 PRS4_DROME 0 GO:0005524; GO:0008283; GO:0005737; GO:0000022; GO:0017111; GO:0005634; GO:0043161; GO:0008540; GO:0006974 "ATP binding; cell proliferation; cytoplasm; mitotic spindle elongation; nucleoside-triphosphatase activity; nucleus; proteasomal ubiquitin-dependent protein catabolic process; proteasome regulatory particle, base subcomplex; response to DNA damage stimulus" IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 4 (P26s4) Pros26.4 P26s4 CG5289 Drosophila melanogaster (Fruit fly) TR36290_c0_g1_i2 P48601 PRS4_DROME 0 GO:0005524; GO:0008283; GO:0005737; GO:0000022; GO:0017111; GO:0005634; GO:0043161; GO:0008540; GO:0006974 "ATP binding; cell proliferation; cytoplasm; mitotic spindle elongation; nucleoside-triphosphatase activity; nucleus; proteasomal ubiquitin-dependent protein catabolic process; proteasome regulatory particle, base subcomplex; response to DNA damage stimulus" IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 4 (P26s4) Pros26.4 P26s4 CG5289 Drosophila melanogaster (Fruit fly) TR36295_c0_g1_i4 Q8S8T8 PCR10_ARATH 7.00E-09 GO:0016021 integral to membrane IPR006461; Protein PLANT CADMIUM RESISTANCE 10 (AtPCR10) PCR10 At2g40935 T20B5 Arabidopsis thaliana (Mouse-ear cress) TR36296_c3_g1_i1 Q3TV65 MPND_MOUSE 2.00E-71 GO:0008233; GO:0006508 peptidase activity; proteolysis IPR000555; MPN domain-containing protein (EC 3.4.-.-) Mpnd Mus musculus (Mouse) TR36297_c0_g2_i1 P86854 PLCL_MYTGA 5.00E-15 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR36297_c0_g2_i2 Q66S03 NATTE_THANI 3.00E-11 GO:0030246; GO:0005576; GO:0006954; GO:0046872 carbohydrate binding; extracellular region; inflammatory response; metal ion binding IPR001304; IPR016186; IPR016187; Galactose-specific lectin nattectin (CTL) Thalassophryne nattereri (Niquim) TR36297_c1_g1_i1 O95460 MATN4_HUMAN 6.00E-07 GO:0030198; GO:0005576; GO:0048678 extracellular matrix organization; extracellular region; response to axon injury IPR000742; IPR013032; IPR000152; IPR009030; IPR019466; IPR002035; Matrilin-4 MATN4 Homo sapiens (Human) TR36297_c1_g1_i2 Q95LI2 VITRN_BOVIN 3.00E-06 GO:0005578 proteinaceous extracellular matrix IPR004043; IPR002035; Vitrin VIT Bos taurus (Bovine) TR36297_c1_g1_i3 P13944 COCA1_CHICK 2.00E-10 GO:0007155; GO:0005581 cell adhesion; collagen IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain (Fibrochimerin) COL12A1 Gallus gallus (Chicken) TR36300_c0_g1_i1 Q8MSU3 FRRS1_DROME 1.00E-37 GO:0000293; GO:0016021 ferric-chelate reductase activity; integral to membrane IPR006593; IPR005018; IPR002861; Putative ferric-chelate reductase 1 homolog (DmSDR2) (EC 1.-.-.-) CG8399 Drosophila melanogaster (Fruit fly) TR36300_c0_g1_i2 Q8MSU3 FRRS1_DROME 3.00E-35 GO:0000293; GO:0016021 ferric-chelate reductase activity; integral to membrane IPR006593; IPR005018; IPR002861; Putative ferric-chelate reductase 1 homolog (DmSDR2) (EC 1.-.-.-) CG8399 Drosophila melanogaster (Fruit fly) TR36301_c4_g1_i2 Q95SX7 RTBS_DROME 2.00E-06 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR36301_c4_g1_i3 P17213 BPI_HUMAN 2.00E-24 GO:0005737; GO:0042742; GO:0005576; GO:0006955; GO:0005887; GO:0001530; GO:0032715; GO:0032717; GO:0043031; GO:0032720 cytoplasm; defense response to bacterium; extracellular region; immune response; integral to plasma membrane; lipopolysaccharide binding; negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; negative regulation of macrophage activation; negative regulation of tumor necrosis factor production IPR017943; IPR001124; IPR017954; IPR017942; Bactericidal permeability-increasing protein (BPI) (CAP 57) BPI Homo sapiens (Human) TR36302_c3_g1_i3 Q2PQH8 GDE_CANFA 0 GO:0004134; GO:0004135; GO:0005737; GO:0005978; GO:0005980; GO:0005634 "4-alpha-glucanotransferase activity; amylo-alpha-1,6-glucosidase activity; cytoplasm; glycogen biosynthetic process; glycogen catabolic process; nucleus" IPR008928; IPR010401; IPR013781; IPR006421; IPR017853; "Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)]" AGL Canis familiaris (Dog) (Canis lupus familiaris) TR36302_c5_g1_i1 Q06625 GDE_YEAST 2.00E-157 GO:0004134; GO:0004135; GO:0005978; GO:0005980; GO:0005739 "4-alpha-glucanotransferase activity; amylo-alpha-1,6-glucosidase activity; glycogen biosynthetic process; glycogen catabolic process; mitochondrion" IPR008928; IPR010401; IPR013781; IPR006421; IPR017853; "Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)]" GDB1 YPR184W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR36302_c5_g1_i2 A8BQB4 GDE_HORSE 0 GO:0004134; GO:0004135; GO:0005737; GO:0005978; GO:0005980 "4-alpha-glucanotransferase activity; amylo-alpha-1,6-glucosidase activity; cytoplasm; glycogen biosynthetic process; glycogen catabolic process" IPR008928; IPR010401; IPR013781; IPR006421; IPR017853; "Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)]" AGL Equus caballus (Horse) TR36303_c3_g1_i1 Q9Y6D6 BIG1_HUMAN 0 GO:0005086; GO:0000139; GO:0007030; GO:0005829; GO:0010256; GO:0006887; GO:0034259; GO:0030837; GO:0016363; GO:0005730; GO:0048471; GO:0090284; GO:0090303; GO:0034237; GO:0015031; GO:0032012; GO:2000114; GO:0030532; GO:0005802 Q9Y6D5; Q7Z4S6; Q7Z4S6-2; Q99417; Q13459-2 ARF guanyl-nucleotide exchange factor activity; Golgi membrane; Golgi organization; cytosol; endomembrane system organization; exocytosis; negative regulation of Rho GTPase activity; negative regulation of actin filament polymerization; nuclear matrix; nucleolus; perinuclear region of cytoplasm; positive regulation of protein glycosylation in Golgi; positive regulation of wound healing; protein kinase A regulatory subunit binding; protein transport; regulation of ARF protein signal transduction; regulation of establishment of cell polarity; small nuclear ribonucleoprotein complex; trans-Golgi network IPR011989; IPR016024; IPR015403; IPR023394; IPR000904; Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) ARFGEF1 ARFGEP1 BIG1 Homo sapiens (Human) TR36303_c3_g2_i2 Q9P7V5 SEC7B_SCHPO 6.00E-20 GO:0005086; GO:0006888; GO:0000137; GO:0000138; GO:0005798; GO:0005938; GO:0006886; GO:0005635; GO:0032012 ARF guanyl-nucleotide exchange factor activity; ER to Golgi vesicle-mediated transport; Golgi cis cisterna; Golgi trans cisterna; Golgi-associated vesicle; cell cortex; intracellular protein transport; nuclear envelope; regulation of ARF protein signal transduction IPR016024; IPR015403; IPR023394; IPR000904; Protein transport protein sec72 sec72 sec7b SPAC30.01c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36303_c3_g2_i3 D4A631 BIG1_RAT 0 GO:0005086; GO:0000139; GO:0007030; GO:0005829; GO:0010256; GO:0034259; GO:0030837; GO:0016363; GO:0005730; GO:0048471; GO:0090284; GO:0090303; GO:0034237; GO:0015031; GO:0032012; GO:2000114; GO:0030532; GO:0005802; GO:0016192 Q63358 ARF guanyl-nucleotide exchange factor activity; Golgi membrane; Golgi organization; cytosol; endomembrane system organization; negative regulation of Rho GTPase activity; negative regulation of actin filament polymerization; nuclear matrix; nucleolus; perinuclear region of cytoplasm; positive regulation of protein glycosylation in Golgi; positive regulation of wound healing; protein kinase A regulatory subunit binding; protein transport; regulation of ARF protein signal transduction; regulation of establishment of cell polarity; small nuclear ribonucleoprotein complex; trans-Golgi network; vesicle-mediated transport IPR011989; IPR016024; IPR015403; IPR023394; IPR000904; Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) Arfgef1 Rattus norvegicus (Rat) TR36303_c3_g2_i4 Q3UGY8 BIG3_MOUSE 9.00E-08 GO:0005086; GO:0016021; GO:0010923; GO:0032012; GO:0005802; GO:0016192 ARF guanyl-nucleotide exchange factor activity; integral to membrane; negative regulation of phosphatase activity; regulation of ARF protein signal transduction; trans-Golgi network; vesicle-mediated transport IPR016024; IPR015403; IPR000904; Brefeldin A-inhibited guanine nucleotide-exchange protein 3 Arfgef3 Big3 D10Bwg1379e Kiaa1244 Mus musculus (Mouse) TR36303_c3_g3_i1 P15305 DYHC_ONCMY 9.00E-06 GO:0035085; GO:0030286; GO:0005874; GO:0003774 cilium axoneme; dynein complex; microtubule; motor activity Dynein heavy chain (DYHC) (Fragment) Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR36305_c0_g1_i1 Q8BMZ5 SEN34_MOUSE 5.00E-32 GO:0006397; GO:0003676; GO:0090305; GO:0005730; GO:0000213; GO:0000214; GO:0000379 mRNA processing; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis; nucleolus; tRNA-intron endonuclease activity; tRNA-intron endonuclease complex; tRNA-type intron splice site recognition and cleavage IPR011856; IPR006677; IPR006676; IPR016690; tRNA-splicing endonuclease subunit Sen34 (EC 3.1.27.9) (Leukocyte receptor cluster member 5 homolog) (tRNA-intron endonuclease Sen34) Tsen34 Leng5 Sen34 Mus musculus (Mouse) TR36305_c0_g1_i2 Q7SAK9 SEN34_NEUCR 2.00E-12 GO:0003676; GO:0090305; GO:0000213; GO:0000214; GO:0000379 nucleic acid binding; nucleic acid phosphodiester bond hydrolysis; tRNA-intron endonuclease activity; tRNA-intron endonuclease complex; tRNA-type intron splice site recognition and cleavage IPR011856; IPR006677; IPR016690; Probable tRNA-splicing endonuclease subunit sen-34 (EC 3.1.27.9) (tRNA-intron endonuclease sen-34) sen-34 B2E7.010 NCU08032 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR36305_c0_g1_i3 Q58819 ENDA_METJA 9.00E-07 GO:0003676; GO:0090305; GO:0006388; GO:0000213 "nucleic acid binding; nucleic acid phosphodiester bond hydrolysis; tRNA splicing, via endonucleolytic cleavage and ligation; tRNA-intron endonuclease activity" IPR011856; IPR006677; IPR006678; IPR006676; IPR016442; tRNA-splicing endonuclease (EC 3.1.27.9) (tRNA-intron endonuclease) endA MJ1424 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR36310_c0_g3_i1 Q52I78 NAMPT_PIG 1.00E-158 GO:0009435; GO:0005737; GO:0047280; GO:0004514 NAD biosynthetic process; cytoplasm; nicotinamide phosphoribosyltransferase activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity IPR007229; IPR016471; IPR002638; Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1. Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1 homolog) (PBEF) (Visfatin) NAMPT PBEF1 Sus scrofa (Pig) TR36310_c0_g3_i10 Q52I78 NAMPT_PIG 7.00E-157 GO:0009435; GO:0005737; GO:0047280; GO:0004514 NAD biosynthetic process; cytoplasm; nicotinamide phosphoribosyltransferase activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity IPR007229; IPR016471; IPR002638; Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1. Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1 homolog) (PBEF) (Visfatin) NAMPT PBEF1 Sus scrofa (Pig) TR36310_c0_g3_i11 P75067 Y047_MYCPN 9.00E-50 GO:0009435; GO:0004514 NAD biosynthetic process; nicotinate-nucleotide diphosphorylase (carboxylating) activity IPR007229; IPR016471; IPR002638; Uncharacterized protein MG037 homolog MPN_047 D09_orf451 MP107 Mycoplasma pneumoniae (strain ATCC 29342 / M129) TR36310_c0_g3_i12 Q52I78 NAMPT_PIG 7.00E-157 GO:0009435; GO:0005737; GO:0047280; GO:0004514 NAD biosynthetic process; cytoplasm; nicotinamide phosphoribosyltransferase activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity IPR007229; IPR016471; IPR002638; Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1. Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1 homolog) (PBEF) (Visfatin) NAMPT PBEF1 Sus scrofa (Pig) TR36310_c0_g3_i14 P75067 Y047_MYCPN 2.00E-49 GO:0009435; GO:0004514 NAD biosynthetic process; nicotinate-nucleotide diphosphorylase (carboxylating) activity IPR007229; IPR016471; IPR002638; Uncharacterized protein MG037 homolog MPN_047 D09_orf451 MP107 Mycoplasma pneumoniae (strain ATCC 29342 / M129) TR36310_c0_g3_i5 Q52I78 NAMPT_PIG 1.00E-158 GO:0009435; GO:0005737; GO:0047280; GO:0004514 NAD biosynthetic process; cytoplasm; nicotinamide phosphoribosyltransferase activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity IPR007229; IPR016471; IPR002638; Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1. Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1 homolog) (PBEF) (Visfatin) NAMPT PBEF1 Sus scrofa (Pig) TR36310_c0_g3_i8 Q52I78 NAMPT_PIG 7.00E-157 GO:0009435; GO:0005737; GO:0047280; GO:0004514 NAD biosynthetic process; cytoplasm; nicotinamide phosphoribosyltransferase activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity IPR007229; IPR016471; IPR002638; Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1. Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1 homolog) (PBEF) (Visfatin) NAMPT PBEF1 Sus scrofa (Pig) TR36312_c3_g1_i1 D3ZZC3 KLH22_RAT 3.00E-07 GO:0031463; GO:0051301; GO:0005813; GO:0005737; GO:0000070; GO:0072686; GO:0007094; GO:0005827; GO:0006513 Cul3-RING ubiquitin ligase complex; cell division; centrosome; cytoplasm; mitotic sister chromatid segregation; mitotic spindle; mitotic spindle assembly checkpoint; polar microtubule; protein monoubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 22 Klhl22 Rattus norvegicus (Rat) TR36312_c3_g2_i1 Q6NRH0 KLH12_XENLA 2.00E-08 GO:0048208; GO:0031463; GO:0030134; GO:0016055; GO:0007275; GO:0006513 COPII vesicle coating; Cul3-RING ubiquitin ligase complex; ER to Golgi transport vesicle; Wnt receptor signaling pathway; multicellular organismal development; protein monoubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 12 klhl12 Xenopus laevis (African clawed frog) TR36312_c3_g2_i2 Q6NRH0 KLH12_XENLA 2.00E-08 GO:0048208; GO:0031463; GO:0030134; GO:0016055; GO:0007275; GO:0006513 COPII vesicle coating; Cul3-RING ubiquitin ligase complex; ER to Golgi transport vesicle; Wnt receptor signaling pathway; multicellular organismal development; protein monoubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 12 klhl12 Xenopus laevis (African clawed frog) TR36313_c0_g1_i1 Q6P1I6 PSD2_MOUSE 8.00E-14 GO:0005086; GO:0030054; GO:0030425; GO:0016021; GO:0030182; GO:0043025; GO:0005543; GO:0032012 ARF guanyl-nucleotide exchange factor activity; cell junction; dendrite; integral to membrane; neuron differentiation; neuronal cell body; phospholipid binding; regulation of ARF protein signal transduction IPR001605; IPR011993; IPR001849; IPR023394; IPR000904; PH and SEC7 domain-containing protein 2 (Pleckstrin homology and SEC7 domain-containing protein 2) Psd2 Mus musculus (Mouse) TR36313_c0_g5_i1 Q9ESQ7 PSD1_RAT 1.00E-69 GO:0005086; GO:0030054; GO:0001409; GO:0015854; GO:0016021; GO:0030182; GO:0005543; GO:0005886; GO:0032012; GO:0001726 ARF guanyl-nucleotide exchange factor activity; cell junction; guanine nucleotide transmembrane transporter activity; guanine transport; integral to membrane; neuron differentiation; phospholipid binding; plasma membrane; regulation of ARF protein signal transduction; ruffle IPR001605; IPR011993; IPR001849; IPR023394; IPR000904; PH and SEC7 domain-containing protein 1 (Exchange factor for ARF6) (Pleckstrin homology and SEC7 domain-containing protein 1) Psd Efa6 Psd1 Rattus norvegicus (Rat) TR36313_c0_g7_i1 Q9H254 SPTN4_HUMAN 3.00E-09 GO:0016605; GO:0003779; GO:0051693; GO:0005912; GO:0007628; GO:0030506; GO:0007411; GO:0043203; GO:0043194; GO:0061337; GO:0070852; GO:0021952; GO:0045162; GO:0007016; GO:0005829; GO:0090002; GO:0009566; GO:0010459; GO:0033268; GO:0016363; GO:0033270; GO:0005543; GO:0005886; GO:0040018; GO:0033135; GO:0002028; GO:0007605; GO:0008091; GO:0030507; GO:0005200; GO:0019226; GO:0016192 Q9NRI5; Q16849 PML body; actin binding; actin filament capping; adherens junction; adult walking behavior; ankyrin binding; axon guidance; axon hillock; axon initial segment; cardiac conduction; cell body fiber; central nervous system projection neuron axonogenesis; clustering of voltage-gated sodium channels; cytoskeletal anchoring at plasma membrane; cytosol; establishment of protein localization to plasma membrane; fertilization; negative regulation of heart rate; node of Ranvier; nuclear matrix; paranode region of axon; phospholipid binding; plasma membrane; positive regulation of multicellular organism growth; regulation of peptidyl-serine phosphorylation; regulation of sodium ion transport; sensory perception of sound; spectrin; spectrin binding; structural constituent of cytoskeleton; transmission of nerve impulse; vesicle-mediated transport IPR001589; IPR001715; IPR001605; IPR011993; IPR001849; IPR018159; IPR016343; IPR002017; "Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)" SPTBN4 KIAA1642 SPTBN3 Homo sapiens (Human) TR36314_c1_g1_i1 Q91YJ5 IF2M_MOUSE 0 GO:0005525; GO:0006184; GO:0003924; GO:0001732; GO:0005739; GO:0006446; GO:0043024; GO:0032790; GO:0008135; GO:0003743 "GTP binding; GTP catabolic process; GTPase activity; formation of translation initiation complex; mitochondrion; regulation of translational initiation; ribosomal small subunit binding; ribosome disassembly; translation factor activity, nucleic acid binding; translation initiation factor activity" IPR000795; IPR027417; IPR005225; IPR000178; IPR015760; IPR023115; IPR009000; IPR004161; "Translation initiation factor IF-2, mitochondrial (IF-2(Mt)) (IF-2Mt) (IF2(mt))" Mtif2 Mus musculus (Mouse) TR36316_c0_g1_i1 A4IFD0 KAD5_BOVIN 1.00E-48 GO:0005524; GO:0046034; GO:0004017; GO:0005813; GO:0005737; GO:0004550; GO:0019206; GO:0009142 ATP binding; ATP metabolic process; adenylate kinase activity; centrosome; cytoplasm; nucleoside diphosphate kinase activity; nucleoside kinase activity; nucleoside triphosphate biosynthetic process IPR000850; IPR006267; IPR003117; IPR027417; Adenylate kinase isoenzyme 5 (AK 5) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 5) Ak5 Bos taurus (Bovine) TR36316_c0_g1_i3 Q9R0Y5 KAD1_MOUSE 5.00E-76 GO:0005524; GO:0046034; GO:0004017; GO:0007050; GO:0005737; GO:0004550; GO:0009142; GO:0001520; GO:0005886; GO:0036126 ATP binding; ATP metabolic process; adenylate kinase activity; cell cycle arrest; cytoplasm; nucleoside diphosphate kinase activity; nucleoside triphosphate biosynthetic process; outer dense fiber; plasma membrane; sperm flagellum IPR000850; IPR006267; IPR027417; Adenylate kinase isoenzyme 1 (AK 1) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (Myokinase) Ak1 Mus musculus (Mouse) TR36317_c2_g1_i1 Q9N658 GFI1_DROME 1.00E-13 GO:0007219; GO:0045465; GO:0003705; GO:0007411; GO:0043425; GO:0008407; GO:0042051; GO:0048813; GO:0043066; GO:0000122; GO:0005634; GO:0007422; GO:0008594; GO:0005700; GO:0016360; GO:0043565; GO:0007601; GO:0008270 Notch signaling pathway; R8 cell differentiation; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; axon guidance; bHLH transcription factor binding; chaeta morphogenesis; compound eye photoreceptor development; dendrite morphogenesis; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter; nucleus; peripheral nervous system development; photoreceptor cell morphogenesis; polytene chromosome; sensory organ precursor cell fate determination; sequence-specific DNA binding; visual perception; zinc ion binding IPR007087; IPR015880; IPR013087; IPR001878; Zinc finger protein sens (Protein senseless) sens Lyra CG32120 Drosophila melanogaster (Fruit fly) TR36317_c2_g1_i2 P10073 ZSC22_HUMAN 2.00E-33 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 22 (Krueppel-related zinc finger protein 2) (Protein HKR2) (Zinc finger protein 50) ZSCAN22 HKR2 ZNF50 Homo sapiens (Human) TR36317_c2_g2_i2 Q0P4X6 ZBT44_XENTR 5.00E-06 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 44 zbtb44 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36319_c1_g1_i1 Q5PQJ7 TBCEL_RAT 8.00E-20 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR027933; IPR000626; Tubulin-specific chaperone cofactor E-like protein (Leucine-rich repeat-containing protein 35) Tbcel Lrrc35 Rattus norvegicus (Rat) TR36319_c3_g1_i2 Q5QJ74 TBCEL_HUMAN 2.00E-21 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR027933; IPR000626; Tubulin-specific chaperone cofactor E-like protein (EL) (Leucine-rich repeat-containing protein 35) TBCEL LRRC35 Homo sapiens (Human) TR36320_c1_g1_i1 Q3B7D5 RASF2_RAT 6.00E-28 GO:0007049; GO:0005737; GO:0005634; GO:0007165 cell cycle; cytoplasm; nucleus; signal transduction IPR000159; IPR011524; Ras association domain-containing protein 2 Rassf2 Rattus norvegicus (Rat) TR36320_c1_g1_i2 Q3B7D5 RASF2_RAT 6.00E-28 GO:0007049; GO:0005737; GO:0005634; GO:0007165 cell cycle; cytoplasm; nucleus; signal transduction IPR000159; IPR011524; Ras association domain-containing protein 2 Rassf2 Rattus norvegicus (Rat) TR36321_c0_g1_i1 O95995 GAS8_HUMAN 0 GO:0005794; GO:0034613; GO:0005874; GO:0005932; GO:0031514; GO:0008285; GO:0030317 O76071 Golgi apparatus; cellular protein localization; microtubule; microtubule basal body; motile cilium; negative regulation of cell proliferation; sperm motility IPR025593; Growth arrest-specific protein 8 (GAS-8) (Growth arrest-specific protein 11) (GAS-11) GAS8 GAS11 Homo sapiens (Human) TR36322_c0_g1_i2 P27701 CD82_HUMAN 2.00E-17 GO:0005887 Q8TAA9 integral to plasma membrane IPR000301; IPR018499; IPR018503; IPR008952; CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82) CD82 KAI1 SAR2 ST6 TSPAN27 Homo sapiens (Human) TR36323_c2_g2_i1 Q8BJU2 TSN9_MOUSE 4.00E-10 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-9 (Tspan-9) (Tetraspan NET-5) Tspan9 Net5 Mus musculus (Mouse) TR36323_c2_g2_i2 B3VSC2 TSN9_SHEEP 7.00E-09 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-9 (Tspan-9) (Tetraspan NET-5) TSPAN9 NET5 Ovis aries (Sheep) TR36323_c2_g2_i4 Q8BJU2 TSN9_MOUSE 4.00E-10 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-9 (Tspan-9) (Tetraspan NET-5) Tspan9 Net5 Mus musculus (Mouse) TR36323_c2_g2_i5 Q86UF1 TSN33_HUMAN 3.00E-07 GO:0016021 integral to membrane IPR000301; IPR018499; IPR008952; Tetraspanin-33 (Tspan-33) (Penumbra) (hPen) (Proerythroblast new membrane) TSPAN33 PEN Homo sapiens (Human) TR36324_c0_g4_i1 Q6ZTW0 TPGS1_HUMAN 3.00E-34 GO:0030534; GO:0030424; GO:0005813; GO:0035085; GO:0030425; GO:0005874; GO:0005932; GO:0007275; GO:0018095; GO:0007288; GO:0007268; GO:0070740; GO:0051648 adult behavior; axon; centrosome; cilium axoneme; dendrite; microtubule; microtubule basal body; multicellular organismal development; protein polyglutamylation; sperm axoneme assembly; synaptic transmission; tubulin-glutamic acid ligase activity; vesicle localization IPR003117; Tubulin polyglutamylase complex subunit 1 (PGs1) TPGS1 C19orf20 Homo sapiens (Human) TR36324_c0_g5_i1 Q6ZTW0 TPGS1_HUMAN 2.00E-09 GO:0030534; GO:0030424; GO:0005813; GO:0035085; GO:0030425; GO:0005874; GO:0005932; GO:0007275; GO:0018095; GO:0007288; GO:0007268; GO:0070740; GO:0051648 adult behavior; axon; centrosome; cilium axoneme; dendrite; microtubule; microtubule basal body; multicellular organismal development; protein polyglutamylation; sperm axoneme assembly; synaptic transmission; tubulin-glutamic acid ligase activity; vesicle localization IPR003117; Tubulin polyglutamylase complex subunit 1 (PGs1) TPGS1 C19orf20 Homo sapiens (Human) TR36327_c1_g1_i1 Q6DTM3 AHI1_RAT 1.00E-113 GO:0070121; GO:0036038; GO:0005912; GO:0005911; GO:0034613; GO:0005814; GO:0042384; GO:0035844; GO:0001947; GO:0030902; GO:0070986; GO:0005932; GO:0001738; GO:0043066; GO:0071599; GO:0035845; GO:0030862; GO:0002092; GO:0045944; GO:0039023; GO:0039008; GO:0050795; GO:0010842; GO:0065001; GO:0007169; GO:0016192 Kupffer's vesicle development; TCTN-B9D complex; adherens junction; cell-cell junction; cellular protein localization; centriole; cilium assembly; cloaca development; heart looping; hindbrain development; left/right axis specification; microtubule basal body; morphogenesis of a polarized epithelium; negative regulation of apoptotic process; otic vesicle development; photoreceptor cell outer segment organization; positive regulation of polarized epithelial cell differentiation; positive regulation of receptor internalization; positive regulation of transcription from RNA polymerase II promoter; pronephric duct morphogenesis; pronephric nephron tubule morphogenesis; regulation of behavior; retina layer formation; specification of axis polarity; transmembrane receptor protein tyrosine kinase signaling pathway; vesicle-mediated transport IPR001452; IPR015943; IPR001680; IPR017986; Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) Ahi1 Rattus norvegicus (Rat) TR36327_c2_g1_i2 Q99L45 IF2B_MOUSE 2.00E-97 GO:0001701; GO:0002176; GO:0008584; GO:0046872; GO:0003743 in utero embryonic development; male germ cell proliferation; male gonad development; metal ion binding; translation initiation factor activity IPR002735; IPR016189; IPR016190; Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta) Eif2s2 Mus musculus (Mouse) TR3633_c0_g1_i1 P08113 ENPL_MOUSE 6.00E-33 GO:0005524; GO:0030433; GO:0003723; GO:0031247; GO:0071318; GO:0005829; GO:0005783; GO:0005788; GO:0005789; GO:0005576; GO:0050750; GO:0042470; GO:0030496; GO:0043066; GO:0048471; GO:0005886; GO:0006457; GO:0019903; GO:0043666; GO:0001666; GO:0046790 ATP binding; ER-associated protein catabolic process; RNA binding; actin rod assembly; cellular response to ATP; cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; extracellular region; low-density lipoprotein particle receptor binding; melanosome; midbody; negative regulation of apoptotic process; perinuclear region of cytoplasm; plasma membrane; protein folding; protein phosphatase binding; regulation of phosphoprotein phosphatase activity; response to hypoxia; virion binding IPR015566; IPR003594; IPR019805; IPR001404; IPR020575; IPR020568; Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Endoplasmic reticulum resident protein 99) (ERp99) (Heat shock protein 90 kDa beta member 1) (Polymorphic tumor rejection antigen 1) (Tumor rejection antigen gp96) Hsp90b1 Grp94 Tra-1 Tra1 Mus musculus (Mouse) TR36330_c0_g1_i1 Q3UMR5 MCU_MOUSE 3.00E-111 GO:0005262; GO:0034704; GO:0019722; GO:0051561; GO:0042593; GO:0006851; GO:0005743; GO:0032024; GO:0035786; GO:0015292 calcium channel activity; calcium channel complex; calcium-mediated signaling; elevation of mitochondrial calcium ion concentration; glucose homeostasis; mitochondrial calcium ion transport; mitochondrial inner membrane; positive regulation of insulin secretion; protein complex oligomerization; uniporter activity IPR006769; "Calcium uniporter protein, mitochondrial (Coiled-coil domain-containing protein 109A)" Mcu Ccdc109a Mus musculus (Mouse) TR36332_c0_g1_i3 A2VE54 UN93A_BOVIN 6.00E-41 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR010291; IPR016196; Protein unc-93 homolog A (Unc-93A) UNC93A Bos taurus (Bovine) TR36333_c1_g1_i1 Q4VC12 MSS51_HUMAN 8.00E-09 GO:0046872; GO:0035176 metal ion binding; social behavior IPR002893; "Putative protein MSS51 homolog, mitochondrial (Zinc finger MYND domain-containing protein 17)" MSS51 ZMYND17 Homo sapiens (Human) TR36334_c0_g1_i1 A2A935 PRD16_MOUSE 3.00E-61 GO:0050873; GO:0046872; GO:0030853; GO:0000122; GO:0030512; GO:0022008; GO:0060021; GO:0045893; GO:0043457; GO:0043565; GO:0035019; GO:0043586; GO:0003713; GO:0006351; GO:0017053; GO:0050872 "brown fat cell differentiation; metal ion binding; negative regulation of granulocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; neurogenesis; palate development; positive regulation of transcription, DNA-dependent; regulation of cellular respiration; sequence-specific DNA binding; somatic stem cell maintenance; tongue development; transcription coactivator activity; transcription, DNA-dependent; transcriptional repressor complex; white fat cell differentiation" IPR001214; IPR007087; IPR015880; IPR013087; PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) Prdm16 Kiaa1675 Mel1 Mus musculus (Mouse) TR36335_c6_g1_i1 Q5UQ13 COLL2_MIMIV 2.00E-21 GO:0005581; GO:0019012 collagen; virion IPR008160; Collagen-like protein 2 MIMI_R196 Acanthamoeba polyphaga mimivirus (APMV) TR36335_c6_g2_i1 A8TX70 CO6A5_HUMAN 1.00E-10 GO:0007155; GO:0005581; GO:0030574; GO:0022617; GO:0005576 cell adhesion; collagen; collagen catabolic process; extracellular matrix disassembly; extracellular region IPR008160; IPR002035; Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) (von Willebrand factor A domain-containing protein 4) COL6A5 COL29A1 VWA4 Homo sapiens (Human) TR36335_c6_g3_i1 P13611 CSPG2_HUMAN 9.00E-17 GO:0005796; GO:0005509; GO:0030246; GO:0005975; GO:0007155; GO:0008037; GO:0030206; GO:0030207; GO:0030208; GO:0030198; GO:0005615; GO:0008347; GO:0007507; GO:0005540; GO:0043202; GO:0007275; GO:0005578 P14780 Golgi lumen; calcium ion binding; carbohydrate binding; carbohydrate metabolic process; cell adhesion; cell recognition; chondroitin sulfate biosynthetic process; chondroitin sulfate catabolic process; dermatan sulfate biosynthetic process; extracellular matrix organization; extracellular space; glial cell migration; heart development; hyaluronic acid binding; lysosomal lumen; multicellular organismal development; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Homo sapiens (Human) TR36335_c6_g3_i11 Q1PBC5 SFTPD_MACMU 4.00E-25 GO:0030246; GO:0005581; GO:0005737; GO:0005615; GO:0048286; GO:0007585; GO:0043129 carbohydrate binding; collagen; cytoplasm; extracellular space; lung alveolus development; respiratory gaseous exchange; surfactant homeostasis IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; IPR015097; Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (Lung surfactant protein D) SFTPD Macaca mulatta (Rhesus macaque) TR36335_c6_g3_i2 P15989 CO6A3_CHICK 6.00E-28 GO:0007155; GO:0005581; GO:0004867 cell adhesion; collagen; serine-type endopeptidase inhibitor activity IPR008160; IPR003961; IPR002223; IPR020901; IPR002035; Collagen alpha-3(VI) chain COL6A3 Gallus gallus (Chicken) TR36335_c6_g3_i6 Q0II24 C1QT9_BOVIN 5.00E-14 GO:0005581 collagen IPR001073; IPR008160; IPR008983; Complement C1q and tumor necrosis factor-related protein 9 C1QTNF9 Bos taurus (Bovine) TR36335_c6_g3_i7 Q9Y6Z7 COL10_HUMAN 3.00E-20 GO:0005581; GO:0005737; GO:0005537 collagen; cytoplasm; mannose binding IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-10 (Collectin liver protein 1) (CL-L1) (Collectin-34) (CL-34) COLEC10 CLL1 UNQ366/PRO702 Homo sapiens (Human) TR36335_c6_g3_i8 Q5U3G1 COL11_DANRE 3.00E-24 GO:0005581; GO:0005537; GO:0001755 collagen; mannose binding; neural crest cell migration IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-11 colec11 zgc:103572 Danio rerio (Zebrafish) (Brachydanio rerio) TR36336_c1_g1_i1 Q16982 NECX_APLCA 1.00E-43 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Neurocalcin Aplysia californica (California sea hare) TR36336_c1_g1_i2 Q6AXL4 NCLDB_DANRE 5.00E-45 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Neurocalcin-delta B ncaldb ncald si:dkey-21k18.3 zgc:100982 Danio rerio (Zebrafish) (Brachydanio rerio) TR36336_c1_g1_i3 A9JTH1 NCLDA_DANRE 1.00E-46 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Neurocalcin-delta A ncalda zgc:175182 Danio rerio (Zebrafish) (Brachydanio rerio) TR36338_c2_g2_i3 Q8N2M8 CLASR_HUMAN 2.00E-77 GO:0008380; GO:0006397; GO:0005634 RNA splicing; mRNA processing; nucleus IPR019147; "CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2)" CLASRP SFRS16 SWAP2 UNQ2428/PRO4988 Homo sapiens (Human) TR36338_c2_g2_i4 Q8N2M8 CLASR_HUMAN 6.00E-79 GO:0008380; GO:0006397; GO:0005634 RNA splicing; mRNA processing; nucleus IPR019147; "CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2)" CLASRP SFRS16 SWAP2 UNQ2428/PRO4988 Homo sapiens (Human) TR36339_c4_g1_i1 Q752Y3 ALO_ASHGO 6.00E-18 GO:0003885; GO:0008762; GO:0034599; GO:0070485; GO:0050660; GO:0031307 "D-arabinono-1,4-lactone oxidase activity; UDP-N-acetylmuramate dehydrogenase activity; cellular response to oxidative stress; dehydro-D-arabinono-1,4-lactone biosynthetic process; flavin adenine dinucleotide binding; integral to mitochondrial outer membrane" IPR007173; IPR016169; IPR016166; IPR016167; IPR010031; IPR023595; IPR006094; IPR006093; "Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2." "D-arabinono-1,4-lactone oxidase (ALO) (EC 1.1.3.37) (L-galactono-gamma-lactone oxidase)" ALO1 AFR440C Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR36339_c4_g1_i3 Q752Y3 ALO_ASHGO 9.00E-18 GO:0003885; GO:0008762; GO:0034599; GO:0070485; GO:0050660; GO:0031307 "D-arabinono-1,4-lactone oxidase activity; UDP-N-acetylmuramate dehydrogenase activity; cellular response to oxidative stress; dehydro-D-arabinono-1,4-lactone biosynthetic process; flavin adenine dinucleotide binding; integral to mitochondrial outer membrane" IPR007173; IPR016169; IPR016166; IPR016167; IPR010031; IPR023595; IPR006094; IPR006093; "Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2." "D-arabinono-1,4-lactone oxidase (ALO) (EC 1.1.3.37) (L-galactono-gamma-lactone oxidase)" ALO1 AFR440C Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR36339_c4_g1_i4 Q6CSY3 ALO_KLULA 2.00E-17 GO:0003885; GO:0008762; GO:0009058; GO:0050660; GO:0031966 "D-arabinono-1,4-lactone oxidase activity; UDP-N-acetylmuramate dehydrogenase activity; biosynthetic process; flavin adenine dinucleotide binding; mitochondrial membrane" IPR007173; IPR016169; IPR016166; IPR016167; IPR010031; IPR023595; IPR006094; IPR006093; "Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2." "D-arabinono-1,4-lactone oxidase (ALO) (EC 1.1.3.37) (L-galactono-gamma-lactone oxidase)" ALO1 KLLA0C16896g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR36341_c0_g1_i2 Q5JXC2 MIIP_HUMAN 2.00E-22 Migration and invasion-inhibitory protein (IGFBP2-binding protein) (Invasion-inhibitory protein 45) (IIp45) MIIP IIP45 Homo sapiens (Human) TR36342_c1_g1_i1 Q28106 CNTN1_BOVIN 1.00E-12 GO:0007219; GO:0031225; GO:0007155; GO:0005886 Notch signaling pathway; anchored to membrane; cell adhesion; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Contactin-1 (Neural cell surface protein F3) CNTN1 Bos taurus (Bovine) TR36342_c3_g1_i1 Q589G5 PRTG_CHICK 9.00E-08 GO:0016021; GO:0007275 integral to membrane; multicellular organismal development IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; Protogenin PRTG Gallus gallus (Chicken) TR36342_c5_g1_i1 P20241 NRG_DROME 4.00E-36 GO:0008366; GO:0048675; GO:0005509; GO:0061343; GO:0048036; GO:0048813; GO:0007173; GO:0060857; GO:0008050; GO:0030175; GO:0007560; GO:0016021; GO:0016328; GO:0008049; GO:0035011; GO:0016319; GO:0021682; GO:0007158; GO:0005919; GO:0045924; GO:0035151; GO:0019991; GO:0050808; GO:0005923 "axon ensheathment; axon extension; calcium ion binding; cell adhesion involved in heart morphogenesis; central complex development; dendrite morphogenesis; epidermal growth factor receptor signaling pathway; establishment of glial blood-brain barrier; female courtship behavior; filopodium; imaginal disc morphogenesis; integral to membrane; lateral plasma membrane; male courtship behavior; melanotic encapsulation of foreign target; mushroom body development; nerve maturation; neuron cell-cell adhesion; pleated septate junction; regulation of female receptivity; regulation of tube size, open tracheal system; septate junction assembly; synapse organization; tight junction" IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013151; IPR026966; Neuroglian Nrg CG1634 Drosophila melanogaster (Fruit fly) TR36343_c2_g1_i2 Q9Y6J8 STYL1_HUMAN 3.00E-68 GO:0035556; GO:0004721 intracellular signal transduction; phosphoprotein phosphatase activity IPR000340; IPR020422; IPR024950; IPR001763; Serine/threonine/tyrosine-interacting-like protein 1 (Dual specificity phosphatase inhibitor MK-STYX) (Dual specificity protein phosphatase 24) (Map kinase phosphatase-like protein MK-STYX) STYXL1 DUSP24 MKSTYX Homo sapiens (Human) TR36344_c8_g2_i1 O14733 MP2K7_HUMAN 2.00E-165 GO:0005524; GO:0038095; GO:0008545; GO:0004708; GO:0002755; GO:0035666; GO:0007257; GO:0006915; GO:0005829; GO:0045087; GO:0000287; GO:0005634; GO:0018108; GO:0043525; GO:0019903; GO:0004674; GO:0004713; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124 O15519-1; Q5S007; O43318; P45983; Q9UQF2 ATP binding; Fc-epsilon receptor signaling pathway; JUN kinase kinase activity; MAP kinase kinase activity; MyD88-dependent toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; activation of JUN kinase activity; apoptotic process; cytosol; innate immune response; magnesium ion binding; nucleus; peptidyl-tyrosine phosphorylation; positive regulation of neuron apoptotic process; protein phosphatase binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor TLR1:TLR2 signaling pathway; toll-like receptor TLR6:TLR2 signaling pathway IPR011009; IPR000719; IPR002290; IPR008271; Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4 Homo sapiens (Human) TR36347_c0_g1_i2 Q5RE03 PRP18_PONAB 9.00E-103 GO:0008380; GO:0006397; GO:0016607; GO:0005681 RNA splicing; mRNA processing; nuclear speck; spliceosomal complex IPR004098; IPR014906; IPR003648; Pre-mRNA-splicing factor 18 (PRP18 homolog) PRPF18 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36348_c0_g2_i1 P97366 EVI5_MOUSE 1.00E-117 GO:0005097; GO:0007049; GO:0051301; GO:0005737; GO:0005815; GO:0005634; GO:0032851; GO:0005819 Rab GTPase activator activity; cell cycle; cell division; cytoplasm; microtubule organizing center; nucleus; positive regulation of Rab GTPase activity; spindle IPR000195; Ecotropic viral integration site 5 protein (EVI-5) Evi5 Mus musculus (Mouse) TR36348_c0_g2_i2 Q9VYY9 Y1727_DROME 4.00E-123 GO:0005097; GO:0007298; GO:0005737; GO:0005768; GO:0030334; GO:0032880; GO:0031982 Rab GTPase activator activity; border follicle cell migration; cytoplasm; endosome; regulation of cell migration; regulation of protein localization; vesicle IPR000195; Ecotropic viral integration site 5 ortholog Evi5 CG11727 Drosophila melanogaster (Fruit fly) TR36349_c3_g2_i3 O35127 C10_MOUSE 6.00E-28 GO:0005737 cytoplasm IPR026317; Protein C10 Grcc10 C10 Mus musculus (Mouse) TR36350_c0_g1_i1 P16112 PGCA_HUMAN 1.00E-19 GO:0005796; GO:0030246; GO:0005975; GO:0007155; GO:0030198; GO:0005201; GO:0005576; GO:0005540; GO:0018146; GO:0042340; GO:0043202; GO:0046872; GO:0005578; GO:0006508; GO:0001501 Golgi lumen; carbohydrate binding; carbohydrate metabolic process; cell adhesion; extracellular matrix organization; extracellular matrix structural constituent; extracellular region; hyaluronic acid binding; keratan sulfate biosynthetic process; keratan sulfate catabolic process; lysosomal lumen; metal ion binding; proteinaceous extracellular matrix; proteolysis; skeletal system development IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR007110; IPR013783; IPR003006; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2] ACAN AGC1 CSPG1 MSK16 Homo sapiens (Human) TR36350_c0_g1_i2 P06734 FCER2_HUMAN 2.00E-16 GO:0007219; GO:0030246; GO:0009897; GO:0005576; GO:0005887; GO:0005178; GO:0046872; GO:0002925; GO:0051712; GO:0051000; GO:0051770 Notch signaling pathway; carbohydrate binding; external side of plasma membrane; extracellular region; integral to plasma membrane; integrin binding; metal ion binding; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of killing of cells of other organism; positive regulation of nitric-oxide synthase activity; positive regulation of nitric-oxide synthase biosynthetic process IPR001304; IPR016186; IPR018378; IPR016187; Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form] FCER2 CD23A CLEC4J FCE2 IGEBF Homo sapiens (Human) TR36350_c0_g1_i3 P06734 FCER2_HUMAN 3.00E-16 GO:0007219; GO:0030246; GO:0009897; GO:0005576; GO:0005887; GO:0005178; GO:0046872; GO:0002925; GO:0051712; GO:0051000; GO:0051770 Notch signaling pathway; carbohydrate binding; external side of plasma membrane; extracellular region; integral to plasma membrane; integrin binding; metal ion binding; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of killing of cells of other organism; positive regulation of nitric-oxide synthase activity; positive regulation of nitric-oxide synthase biosynthetic process IPR001304; IPR016186; IPR018378; IPR016187; Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form] FCER2 CD23A CLEC4J FCE2 IGEBF Homo sapiens (Human) TR36350_c0_g2_i1 Q9WVF9 CLC2I_MOUSE 2.00E-08 GO:0050852; GO:0030246; GO:0009897; GO:0016021; GO:0001765; GO:0046703; GO:0045671; GO:2000522; GO:0043113; GO:0042129; GO:0030833; GO:0045076; GO:0004888 T cell receptor signaling pathway; carbohydrate binding; external side of plasma membrane; integral to membrane; membrane raft assembly; natural killer cell lectin-like receptor binding; negative regulation of osteoclast differentiation; positive regulation of immunological synapse formation; receptor clustering; regulation of T cell proliferation; regulation of actin filament polymerization; regulation of interleukin-2 biosynthetic process; transmembrane signaling receptor activity IPR001304; IPR016186; IPR016187; C-type lectin domain family 2 member I (C-type lectin-related protein DCL1) (C-type lectin-related protein G) (Clr-g) (Lymphoid-derived C-type lectin-1) (LCL-1) (Osteoclast inhibitory lectin-related protein 2) (Ocil-related protein 2) Clec2i Clrg Dcl1 Ocilrp2 Mus musculus (Mouse) TR36350_c0_g2_i2 Q28343 PGCA_CANFA 8.00E-20 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003006; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Canis familiaris (Dog) (Canis lupus familiaris) TR36350_c0_g2_i3 P16112 PGCA_HUMAN 2.00E-20 GO:0005796; GO:0030246; GO:0005975; GO:0007155; GO:0030198; GO:0005201; GO:0005576; GO:0005540; GO:0018146; GO:0042340; GO:0043202; GO:0046872; GO:0005578; GO:0006508; GO:0001501 Golgi lumen; carbohydrate binding; carbohydrate metabolic process; cell adhesion; extracellular matrix organization; extracellular matrix structural constituent; extracellular region; hyaluronic acid binding; keratan sulfate biosynthetic process; keratan sulfate catabolic process; lysosomal lumen; metal ion binding; proteinaceous extracellular matrix; proteolysis; skeletal system development IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR007110; IPR013783; IPR003006; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2] ACAN AGC1 CSPG1 MSK16 Homo sapiens (Human) TR36352_c0_g1_i1 Q9VY77 AJUBA_DROME 1.00E-128 GO:0003779; GO:0005912; GO:0035329; GO:0007067; GO:0045572; GO:0071539; GO:0008270 actin binding; adherens junction; hippo signaling cascade; mitosis; positive regulation of imaginal disc growth; protein localization to centrosome; zinc ion binding IPR001781; LIM domain-containing protein jub jub CG11063 Drosophila melanogaster (Fruit fly) TR36352_c0_g1_i2 Q54QR1 LIMA_DICDI 3.00E-11 GO:0008270 zinc ion binding IPR001781; LIM domain-containing protein A limA DDB_G0283599 Dictyostelium discoideum (Slime mold) TR36354_c2_g1_i1 Q5R4Q7 LZTR1_PONAB 7.00E-16 IPR000210; IPR011333; IPR013069; IPR015915; IPR006652; Leucine-zipper-like transcriptional regulator 1 (LZTR-1) LZTR1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36354_c2_g1_i3 Q5U3Y0 KLD10_RAT 1.00E-112 GO:0005737; GO:0005634 cytoplasm; nucleus IPR011043; IPR015915; IPR006652; Kelch domain-containing protein 10 Klhdc10 Rattus norvegicus (Rat) TR36355_c0_g1_i1 Q8YV57 Y2124_NOSS1 7.00E-09 GO:0004197; GO:0006508 cysteine-type endopeptidase activity; proteolysis IPR020472; IPR027417; IPR011600; IPR015943; IPR001680; IPR019775; IPR017986; Uncharacterized WD repeat-containing protein all2124 all2124 Nostoc sp. (strain PCC 7120 / UTEX 2576) TR36355_c0_g1_i2 Q566T0 EED_DANRE 3.00E-174 GO:0035098; GO:0016568; GO:0006355; GO:0006351 "ESC/E(Z) complex; chromatin modification; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR015943; IPR001680; IPR019775; IPR017986; Polycomb protein eed eed zgc:112509 Danio rerio (Zebrafish) (Brachydanio rerio) TR36356_c0_g2_i2 Q9KDN4 PRSA_BACHD 2.00E-13 GO:0003755; GO:0005886; GO:0006457; GO:0000413 peptidyl-prolyl cis-trans isomerase activity; plasma membrane; protein folding; protein peptidyl-prolyl isomerization IPR023059; IPR000297; IPR027304; Foldase protein PrsA (EC 5.2.1.8) prsA BH1177 Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) TR36356_c0_g2_i3 Q503Y7 PIN4_DANRE 4.00E-52 GO:0003677; GO:0005737; GO:0005730; GO:0003755; GO:0006457; GO:0000413; GO:0005819 DNA binding; cytoplasm; nucleolus; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization; spindle IPR000297; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Parvulin-14) (Par14) (Peptidyl-prolyl cis-trans isomerase Pin4) (PPIase Pin4) (Rotamase Pin4) pin4 zgc:110008 Danio rerio (Zebrafish) (Brachydanio rerio) TR36357_c3_g1_i2 Q5R7C5 ERLN2_PONAB 2.00E-138 GO:0030433; GO:0005789; GO:0016021; GO:0043234 ER-associated protein catabolic process; endoplasmic reticulum membrane; integral to membrane; protein complex IPR001107; Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2) ERLIN2 SPFH2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36358_c2_g3_i1 Q9P258 RCC2_HUMAN 3.00E-159 GO:0051301; GO:0000775; GO:0005829; GO:0005874; GO:0007067; GO:0000278; GO:0005730; GO:0005819 "cell division; chromosome, centromeric region; cytosol; microtubule; mitosis; mitotic cell cycle; nucleolus; spindle" IPR009091; IPR000408; Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) RCC2 KIAA1470 TD60 Homo sapiens (Human) TR36358_c2_g3_i2 Q9P258 RCC2_HUMAN 2.00E-59 GO:0051301; GO:0000775; GO:0005829; GO:0005874; GO:0007067; GO:0000278; GO:0005730; GO:0005819 "cell division; chromosome, centromeric region; cytosol; microtubule; mitosis; mitotic cell cycle; nucleolus; spindle" IPR009091; IPR000408; Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) RCC2 KIAA1470 TD60 Homo sapiens (Human) TR36360_c0_g1_i1 Q01578 GNL_ZYMMO 9.00E-06 GO:0046178; GO:0004091; GO:0004341; GO:0042597 D-gluconate biosynthetic process; carboxylesterase activity; gluconolactonase activity; periplasmic space IPR011042; IPR013658; IPR005511; IPR006311; "Carbohydrate acid metabolism; D-gluconate biosynthesis; D-gluconate from D-glucono-1,5-lactone: step 1/1." Gluconolactonase (EC 3.1.1.17) (D-glucono-delta-lactone lactonohydrolase) [Cleaved into: Gluconolactonase; Gluconolactonase minor isoform] gnl ZMO1649 Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) TR36360_c0_g1_i2 Q06AA3 RGN_PIG 1.00E-78 GO:0019853; GO:0005509; GO:0005737; GO:0030234; GO:0004341; GO:0050790; GO:0008270 L-ascorbic acid biosynthetic process; calcium ion binding; cytoplasm; enzyme regulator activity; gluconolactonase activity; regulation of catalytic activity; zinc ion binding IPR011042; IPR008367; IPR013658; IPR005511; Cofactor biosynthesis; L-ascorbate biosynthesis via UDP-alpha-D-glucuronate pathway; L-ascorbate from UDP-alpha-D-glucuronate: step 3/4. Regucalcin (RC) (Gluconolactonase) (GNL) (EC 3.1.1.17) (Senescence marker protein 30) (SMP-30) RGN SMP30 Sus scrofa (Pig) TR36361_c1_g2_i1 P48987 ATO_DROME 2.00E-08 GO:0001746; GO:0003677; GO:0045464; GO:0000187; GO:0048801; GO:0007420; GO:0048813; GO:0007173; GO:0045433; GO:0008038; GO:0005634; GO:0007438; GO:0001748; GO:0007422; GO:0045944; GO:0016330; GO:0016360; GO:0007605; GO:0007224; GO:0006366 "Bolwig's organ morphogenesis; DNA binding; R8 cell fate specification; activation of MAPK activity; antennal joint morphogenesis; brain development; dendrite morphogenesis; epidermal growth factor receptor signaling pathway; male courtship behavior, veined wing generated song production; neuron recognition; nucleus; oenocyte development; optic lobe placode development; peripheral nervous system development; positive regulation of transcription from RNA polymerase II promoter; second mitotic wave involved in compound eye morphogenesis; sensory organ precursor cell fate determination; sensory perception of sound; smoothened signaling pathway; transcription from RNA polymerase II promoter" IPR011598; Protein atonal ato CG7508 Drosophila melanogaster (Fruit fly) TR36361_c1_g2_i2 B6VQA1 DIMM_DROME 9.00E-26 GO:0003677; GO:0030154; GO:0005737; GO:0007275; GO:0005634; GO:0046887; GO:0002793; GO:0045944; GO:0006351 "DNA binding; cell differentiation; cytoplasm; multicellular organismal development; nucleus; positive regulation of hormone secretion; positive regulation of peptide secretion; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR011598; Protein dimmed dimm CG8667 Drosophila melanogaster (Fruit fly) TR36363_c1_g2_i1 Q9ES54 NPL4_RAT 5.00E-128 GO:0034098; GO:0007030; GO:0005829; GO:0061025; GO:0005634; GO:0043161; GO:0043130; GO:0031625; GO:0008270 Cdc48p-Npl4p-Ufd1p AAA ATPase complex; Golgi organization; cytosol; membrane fusion; nucleus; proteasomal ubiquitin-dependent protein catabolic process; ubiquitin binding; ubiquitin protein ligase binding; zinc ion binding IPR007717; IPR024682; IPR007716; IPR016563; IPR001876; Protein degradation; proteasomal ubiquitin-dependent pathway. Nuclear protein localization protein 4 homolog (Protein NPL4) Nploc4 Npl4 Rattus norvegicus (Rat) TR36364_c1_g1_i1 A6NCI4 VWA3A_HUMAN 0 GO:0005576 extracellular region IPR002035; von Willebrand factor A domain-containing protein 3A VWA3A Homo sapiens (Human) TR36364_c1_g1_i5 A1A5Q7 VWA3A_RAT 2.00E-57 IPR002035; von Willebrand factor A domain-containing protein 3A Vwa3a Rattus norvegicus (Rat) TR36364_c2_g1_i1 A6NCI4 VWA3A_HUMAN 6.00E-99 GO:0005576 extracellular region IPR002035; von Willebrand factor A domain-containing protein 3A VWA3A Homo sapiens (Human) TR36368_c0_g1_i2 Q64612 PTPRV_RAT 3.00E-42 GO:0046849; GO:0016021; GO:0035335; GO:0004725 bone remodeling; integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase V (R-PTP-V) (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase) (Osteotesticular protein-tyrosine phosphatase) (OST-PTP) Ptprv Esp Rattus norvegicus (Rat) TR36368_c0_g1_i3 Q99M80 PTPRT_MOUSE 7.00E-87 GO:0051393; GO:0045294; GO:0008013; GO:0009986; GO:0007156; GO:0016021; GO:0005886; GO:0004725; GO:0016790; GO:0007169 alpha-actinin binding; alpha-catenin binding; beta-catenin binding; cell surface; homophilic cell adhesion; integral to membrane; plasma membrane; protein tyrosine phosphatase activity; thiolester hydrolase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) TR36368_c0_g1_i4 P23469 PTPRE_HUMAN 8.00E-76 GO:0005737; GO:0016021; GO:0045111; GO:0046627; GO:0005634; GO:0005886; GO:0033003; GO:0005001; GO:0007185 cytoplasm; integral to membrane; intermediate filament cytoskeleton; negative regulation of insulin receptor signaling pathway; nucleus; plasma membrane; regulation of mast cell activation; transmembrane receptor protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase signaling pathway IPR000387; IPR016130; IPR000242; IPR016336; Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) TR36368_c0_g2_i1 Q14162 SREC_HUMAN 8.00E-08 GO:0007155; GO:0006707; GO:0016358; GO:0030666; GO:0016021; GO:0030169; GO:0016322; GO:0005886; GO:0048680; GO:0005044; GO:0004888 cell adhesion; cholesterol catabolic process; dendrite development; endocytic vesicle membrane; integral to membrane; low-density lipoprotein particle binding; neuron remodeling; plasma membrane; positive regulation of axon regeneration; scavenger receptor activity; transmembrane signaling receptor activity IPR000742; IPR013032; IPR002049; IPR009030; Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) TR36369_c0_g1_i1 O73777 IF4G2_CHICK 3.00E-22 GO:0006417; GO:0003743 regulation of translation; translation initiation factor activity IPR016024; IPR016021; IPR003307; Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (p97) (Fragment) EIF4G2 Gallus gallus (Chicken) TR36369_c0_g2_i1 Q62448 IF4G2_MOUSE 2.00E-87 GO:0016281; GO:0006446; GO:0003743 Q61823; P26450 eukaryotic translation initiation factor 4F complex; regulation of translational initiation; translation initiation factor activity IPR016024; IPR003891; IPR016021; IPR003890; IPR003307; Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Novel APOBEC-1 target 1) (Translation repressor NAT1) (p97) Eif4g2 Nat1 Mus musculus (Mouse) TR36370_c1_g1_i2 Q55E98 Y9332_DICDI 2.00E-12 GO:0008324; GO:0016021; GO:0046872; GO:0006829 cation transmembrane transporter activity; integral to membrane; metal ion binding; zinc ion transport IPR002524; IPR027469; IPR002395; Probable zinc transporter protein DDB_G0269332 DDB_G0269332 Dictyostelium discoideum (Slime mold) TR36370_c1_g1_i3 Q6NRI1 ZNT7B_XENLA 4.00E-10 GO:0005794; GO:0008324; GO:0016021; GO:0006829 Golgi apparatus; cation transmembrane transporter activity; integral to membrane; zinc ion transport IPR002524; IPR027469; Zinc transporter 7-B (ZnT-7-B) (Solute carrier family 30 member 7-B) slc30a7-b znt7-b Xenopus laevis (African clawed frog) TR36370_c1_g1_i4 Q6AZN8 ZNT6A_XENLA 2.00E-141 GO:0005794; GO:0008324; GO:0016021; GO:0006829 Golgi apparatus; cation transmembrane transporter activity; integral to membrane; zinc ion transport IPR002524; IPR027469; Zinc transporter 6-A (ZnT-6-A) (Solute carrier family 30 member 6-A) slc30a6-a znt6-a Xenopus laevis (African clawed frog) TR36371_c0_g4_i1 Q7TSG2 CTDP1_MOUSE 1.00E-83 GO:0008420; GO:0015629; GO:0051301; GO:0005813; GO:0005737; GO:0010458; GO:0030496; GO:0005634; GO:0006470; GO:0051233; GO:0000922 CTD phosphatase activity; actin cytoskeleton; cell division; centrosome; cytoplasm; exit from mitosis; midbody; nucleus; protein dephosphorylation; spindle midzone; spindle pole IPR001357; IPR015388; IPR011947; IPR023214; IPR004274; IPR011053; RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase) Ctdp1 Fcp1 Mus musculus (Mouse) TR36371_c0_g4_i2 Q03254 FCP1_YEAST 5.00E-31 GO:0005829; GO:0070940; GO:0005634; GO:0004722 cytosol; dephosphorylation of RNA polymerase II C-terminal domain; nucleus; protein serine/threonine phosphatase activity IPR001357; IPR011947; IPR023214; IPR004274; RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (CTD phosphatase FCP1) FCP1 YMR277W YM8021.03 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR36372_c3_g2_i2 Q3LGD4 RFP4A_DANRE 2.00E-50 GO:0030306; GO:0017137; GO:0005509; GO:0032154; GO:0000910; GO:0030139; GO:0048592; GO:0030496; GO:0042803; GO:0055038; GO:0051726; GO:0043565; GO:0003700; GO:0006810 ADP-ribosylation factor binding; Rab GTPase binding; calcium ion binding; cleavage furrow; cytokinesis; endocytic vesicle; eye morphogenesis; midbody; protein homodimerization activity; recycling endosome membrane; regulation of cell cycle; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transport IPR004827; IPR011992; IPR002048; IPR019018; Rab11 family-interacting protein 4A (FIP4-Rab11) (Rab11-FIP4-A) (zRab11-FIP4-A) rab11fip4a rab11fip4 Danio rerio (Zebrafish) (Brachydanio rerio) TR36372_c3_g2_i4 Q3LGD4 RFP4A_DANRE 2.00E-48 GO:0030306; GO:0017137; GO:0005509; GO:0032154; GO:0000910; GO:0030139; GO:0048592; GO:0030496; GO:0042803; GO:0055038; GO:0051726; GO:0043565; GO:0003700; GO:0006810 ADP-ribosylation factor binding; Rab GTPase binding; calcium ion binding; cleavage furrow; cytokinesis; endocytic vesicle; eye morphogenesis; midbody; protein homodimerization activity; recycling endosome membrane; regulation of cell cycle; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transport IPR004827; IPR011992; IPR002048; IPR019018; Rab11 family-interacting protein 4A (FIP4-Rab11) (Rab11-FIP4-A) (zRab11-FIP4-A) rab11fip4a rab11fip4 Danio rerio (Zebrafish) (Brachydanio rerio) TR36374_c0_g1_i2 P05400 POL_CERV 3.00E-06 GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR000588; IPR000477; Enzymatic polyprotein [Includes: Aspartic protease (EC 3.4.23.-); Endonuclease; Reverse transcriptase (EC 2.7.7.49)] ORF V Carnation etched ring virus (CERV) TR36375_c0_g1_i1 Q7JUX9 MRRP1_DROME 4.00E-42 GO:0008168; GO:0005739; GO:0008033 methyltransferase activity; mitochondrion; tRNA processing IPR025812; IPR016009; IPR007356; Mitochondrial ribonuclease P protein 1 homolog (Mitochondrial RNase P protein 1) (EC 2.1.1.-) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (tRNA methyltransferase 10 homolog C) trmt10c CG5190 Drosophila melanogaster (Fruit fly) TR36376_c3_g1_i1 P07814 SYEP_HUMAN 0 GO:0005524; GO:0035613; GO:0071346; GO:0005829; GO:0004818; GO:0006424; GO:0017148; GO:0004827; GO:0006433; GO:0006461; GO:0030529; GO:0006418 P41252 ATP binding; RNA stem-loop binding; cellular response to interferon-gamma; cytosol; glutamate-tRNA ligase activity; glutamyl-tRNA aminoacylation; negative regulation of translation; proline-tRNA ligase activity; prolyl-tRNA aminoacylation; protein complex assembly; ribonucleoprotein complex; tRNA aminoacylation for protein translation IPR002314; IPR001412; IPR006195; IPR004154; IPR004526; IPR000924; IPR020061; IPR020058; IPR020059; IPR010987; IPR004499; IPR016061; IPR017449; IPR020056; IPR011035; IPR014729; IPR009068; IPR000738; Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] EPRS GLNS PARS QARS QPRS PIG32 Homo sapiens (Human) TR36376_c3_g1_i2 P28668 SYEP_DROME 0 GO:0005524; GO:0003723; GO:0005737; GO:0004818; GO:0006424; GO:0004827; GO:0006433 ATP binding; RNA binding; cytoplasm; glutamate-tRNA ligase activity; glutamyl-tRNA aminoacylation; proline-tRNA ligase activity; prolyl-tRNA aminoacylation IPR002314; IPR001412; IPR006195; IPR004154; IPR004526; IPR000924; IPR020061; IPR020058; IPR020059; IPR010987; IPR004499; IPR016061; IPR017449; IPR020056; IPR011035; IPR014729; IPR009068; IPR000738; Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)] Aats-glupro CG5394 Drosophila melanogaster (Fruit fly) TR36376_c3_g1_i4 B9LUM0 SYP_HALLT 3.00E-40 GO:0005524; GO:0005737; GO:0004827; GO:0006433 ATP binding; cytoplasm; proline-tRNA ligase activity; prolyl-tRNA aminoacylation IPR002314; IPR006195; IPR004154; IPR002316; IPR004499; IPR016061; IPR017449; Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS) proS Hlac_0777 Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34) TR36376_c3_g1_i5 P28668 SYEP_DROME 1.00E-75 GO:0005524; GO:0003723; GO:0005737; GO:0004818; GO:0006424; GO:0004827; GO:0006433 ATP binding; RNA binding; cytoplasm; glutamate-tRNA ligase activity; glutamyl-tRNA aminoacylation; proline-tRNA ligase activity; prolyl-tRNA aminoacylation IPR002314; IPR001412; IPR006195; IPR004154; IPR004526; IPR000924; IPR020061; IPR020058; IPR020059; IPR010987; IPR004499; IPR016061; IPR017449; IPR020056; IPR011035; IPR014729; IPR009068; IPR000738; Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)] Aats-glupro CG5394 Drosophila melanogaster (Fruit fly) TR36377_c1_g1_i1 Q9CZJ2 HS12B_MOUSE 9.00E-87 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR36377_c1_g1_i4 Q886Z7 HSCA_PSESM 1.00E-07 GO:0005524; GO:0016887; GO:0016226; GO:0006457 ATP binding; ATPase activity; iron-sulfur cluster assembly; protein folding IPR018181; IPR013126; IPR010236; Chaperone protein HscA homolog hscA PSPTO_1427 Pseudomonas syringae pv. tomato (strain DC3000) TR36378_c0_g1_i1 Q6TGZ5 HPPD_DANRE 1.00E-111 GO:0003868; GO:0006559; GO:0004462; GO:0046872; GO:0006572 4-hydroxyphenylpyruvate dioxygenase activity; L-phenylalanine catabolic process; lactoylglutathione lyase activity; metal ion binding; tyrosine catabolic process IPR005956; IPR004360; IPR018146; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6. 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4-hydroxyphenylpyruvic acid oxidase) (4HPPD) (HPD) (HPPDase) hpd zgc:56326 Danio rerio (Zebrafish) (Brachydanio rerio) TR36379_c0_g1_i1 A1YG61 EHF_PANPA 2.00E-34 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; ETS homologous factor (ETS domain-containing transcription factor) EHF Pan paniscus (Pygmy chimpanzee) (Bonobo) TR36380_c1_g1_i1 Q9VWH4 IDH3A_DROME 0 GO:0051287; GO:0004449; GO:0005811; GO:0000287; GO:0005875; GO:0005739; GO:0006099 NAD binding; isocitrate dehydrogenase (NAD+) activity; lipid particle; magnesium ion binding; microtubule associated complex; mitochondrion; tricarboxylic acid cycle IPR019818; IPR001804; IPR004434; IPR024084; "Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha)" l(1)G0156 CG12233 Drosophila melanogaster (Fruit fly) TR36382_c2_g1_i2 Q5E9U9 NPRL2_BOVIN 7.00E-119 GO:0005096; GO:0005737; GO:0033673; GO:0043547; GO:0004672 GTPase activator activity; cytoplasm; negative regulation of kinase activity; positive regulation of GTPase activity; protein kinase activity IPR009348; Nitrogen permease regulator 2-like protein (NPR2-like protein) (Tumor suppressor candidate 4) NPRL2 TUSC4 Bos taurus (Bovine) TR36382_c2_g1_i4 O42857 NPR2_SCHPO 7.00E-40 GO:0034198; GO:0005829; GO:0005634; GO:0032006; GO:0070881; GO:0006355; GO:0006351 "cellular response to amino acid starvation; cytosol; nucleus; regulation of TOR signaling cascade; regulation of proline transport; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009348; Nitrogen permease regulator 2 homolog SPAC23H3.03c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36382_c2_g1_i5 Q5E9U9 NPRL2_BOVIN 1.00E-118 GO:0005096; GO:0005737; GO:0033673; GO:0043547; GO:0004672 GTPase activator activity; cytoplasm; negative regulation of kinase activity; positive regulation of GTPase activity; protein kinase activity IPR009348; Nitrogen permease regulator 2-like protein (NPR2-like protein) (Tumor suppressor candidate 4) NPRL2 TUSC4 Bos taurus (Bovine) TR36382_c2_g1_i8 Q5E9U9 NPRL2_BOVIN 2.00E-118 GO:0005096; GO:0005737; GO:0033673; GO:0043547; GO:0004672 GTPase activator activity; cytoplasm; negative regulation of kinase activity; positive regulation of GTPase activity; protein kinase activity IPR009348; Nitrogen permease regulator 2-like protein (NPR2-like protein) (Tumor suppressor candidate 4) NPRL2 TUSC4 Bos taurus (Bovine) TR36384_c2_g4_i7 P36975 SNP25_DROME 2.00E-77 GO:0006893; GO:0005484; GO:0031201; GO:0030054; GO:0043005; GO:0005886; GO:0048172; GO:0045202; GO:0016081; GO:0016082 Golgi to plasma membrane transport; SNAP receptor activity; SNARE complex; cell junction; neuron projection; plasma membrane; regulation of short-term neuronal synaptic plasticity; synapse; synaptic vesicle docking involved in exocytosis; synaptic vesicle priming IPR000928; IPR000727; Synaptosomal-associated protein 25 (SNAP-25) (Synaptosomal-associated 25 kDa protein) Snap25 CG40452 Drosophila melanogaster (Fruit fly) TR36385_c0_g2_i1 P38942 CAT2_CLOK5 7.00E-112 GO:0006084; GO:0016740 acetyl-CoA metabolic process; transferase activity IPR026888; IPR003702; 4-hydroxybutyrate coenzyme A transferase (EC 2.8.3.-) cat2 CKL_3018 Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) TR36386_c2_g1_i2 P35738 ODBB_RAT 2.00E-80 GO:0003863; GO:0003826; GO:0009083; GO:0005947; GO:0051591; GO:0051384; GO:0007584 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity; alpha-ketoacid dehydrogenase activity; branched-chain amino acid catabolic process; mitochondrial alpha-ketoglutarate dehydrogenase complex; response to cAMP; response to glucocorticoid stimulus; response to nutrient IPR009014; IPR005475; IPR005476; "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDE1B) (BCKDH E1-beta)" Bckdhb Rattus norvegicus (Rat) TR36386_c2_g1_i3 P86222 ODPB_MESAU 1.00E-12 GO:0006086; GO:0006006; GO:0005759; GO:0004739; GO:0004738; GO:0045254; GO:0006099 acetyl-CoA biosynthetic process from pyruvate; glucose metabolic process; mitochondrial matrix; pyruvate dehydrogenase (acetyl-transferring) activity; pyruvate dehydrogenase activity; pyruvate dehydrogenase complex; tricarboxylic acid cycle IPR009014; IPR005475; IPR005476; "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1) (Fragments)" PDHB Mesocricetus auratus (Golden hamster) TR36386_c2_g1_i6 B1XKC5 DXS_SYNP2 2.00E-08 GO:0052865; GO:0008661; GO:0000287; GO:0016114; GO:0009228; GO:0030976 1-deoxy-D-xylulose 5-phosphate biosynthetic process; 1-deoxy-D-xylulose-5-phosphate synthase activity; magnesium ion binding; terpenoid biosynthetic process; thiamine biosynthetic process; thiamine pyrophosphate binding IPR005477; IPR009014; IPR005475; IPR020826; IPR005476; IPR005474; Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) dxs SYNPCC7002_A1172 Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) TR36386_c2_g1_i7 Q5SLR3 ODBB_THET8 1.00E-47 GO:0003863 Q5SLR4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity IPR009014; IPR005475; IPR005476; 2-oxoisovalerate dehydrogenase subunit beta (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDH E1-beta) TTHA0230 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) TR36386_c2_g2_i1 P35738 ODBB_RAT 1.00E-94 GO:0003863; GO:0003826; GO:0009083; GO:0005947; GO:0051591; GO:0051384; GO:0007584 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity; alpha-ketoacid dehydrogenase activity; branched-chain amino acid catabolic process; mitochondrial alpha-ketoglutarate dehydrogenase complex; response to cAMP; response to glucocorticoid stimulus; response to nutrient IPR009014; IPR005475; IPR005476; "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDE1B) (BCKDH E1-beta)" Bckdhb Rattus norvegicus (Rat) TR36387_c0_g1_i1 Q94BV5 GSXL4_ARATH 5.00E-71 GO:0004499; GO:0050661; GO:0050660; GO:0005773 "N,N-dimethylaniline monooxygenase activity; NADP binding; flavin adenine dinucleotide binding; vacuole" IPR000960; IPR020946; Flavin-containing monooxygenase FMO GS-OX-like 4 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 4) At1g62600 T3P18.16 Arabidopsis thaliana (Mouse-ear cress) TR36389_c0_g1_i1 Q3UGY8 BIG3_MOUSE 9.00E-44 GO:0005086; GO:0016021; GO:0010923; GO:0032012; GO:0005802; GO:0016192 ARF guanyl-nucleotide exchange factor activity; integral to membrane; negative regulation of phosphatase activity; regulation of ARF protein signal transduction; trans-Golgi network; vesicle-mediated transport IPR016024; IPR015403; IPR000904; Brefeldin A-inhibited guanine nucleotide-exchange protein 3 Arfgef3 Big3 D10Bwg1379e Kiaa1244 Mus musculus (Mouse) TR36389_c3_g1_i1 Q5TH69 BIG3_HUMAN 2.00E-77 GO:0005086; GO:0016021; GO:0010923; GO:0032012; GO:0005802; GO:0016192 ARF guanyl-nucleotide exchange factor activity; integral to membrane; negative regulation of phosphatase activity; regulation of ARF protein signal transduction; trans-Golgi network; vesicle-mediated transport IPR016024; IPR015403; IPR000904; Brefeldin A-inhibited guanine nucleotide-exchange protein 3 ARFGEF3 BIG3 C6orf92 KIAA1244 Homo sapiens (Human) TR36389_c3_g1_i3 Q9P7V5 SEC7B_SCHPO 3.00E-06 GO:0005086; GO:0006888; GO:0000137; GO:0000138; GO:0005798; GO:0005938; GO:0006886; GO:0005635; GO:0032012 ARF guanyl-nucleotide exchange factor activity; ER to Golgi vesicle-mediated transport; Golgi cis cisterna; Golgi trans cisterna; Golgi-associated vesicle; cell cortex; intracellular protein transport; nuclear envelope; regulation of ARF protein signal transduction IPR016024; IPR015403; IPR023394; IPR000904; Protein transport protein sec72 sec72 sec7b SPAC30.01c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36389_c3_g1_i4 Q5TH69 BIG3_HUMAN 2.00E-81 GO:0005086; GO:0016021; GO:0010923; GO:0032012; GO:0005802; GO:0016192 ARF guanyl-nucleotide exchange factor activity; integral to membrane; negative regulation of phosphatase activity; regulation of ARF protein signal transduction; trans-Golgi network; vesicle-mediated transport IPR016024; IPR015403; IPR000904; Brefeldin A-inhibited guanine nucleotide-exchange protein 3 ARFGEF3 BIG3 C6orf92 KIAA1244 Homo sapiens (Human) TR36390_c0_g1_i2 Q61164 CTCF_MOUSE 5.00E-06 GO:0003677; GO:0043035; GO:0016568; GO:0007059; GO:0000775; GO:0000793; GO:0009048; GO:0010216; GO:0046872; GO:0010629; GO:0045892; GO:0005730; GO:0005654; GO:0016584; GO:0005634; GO:0010628; GO:0045893; GO:0006349; GO:0035065; GO:0031060; GO:0040030; GO:0006355; GO:0043565; GO:0003700; GO:0044212; GO:0006351 Q09XV5 "DNA binding; chromatin insulator sequence binding; chromatin modification; chromosome segregation; chromosome, centromeric region; condensed chromosome; dosage compensation by inactivation of X chromosome; maintenance of DNA methylation; metal ion binding; negative regulation of gene expression; negative regulation of transcription, DNA-dependent; nucleolus; nucleoplasm; nucleosome positioning; nucleus; positive regulation of gene expression; positive regulation of transcription, DNA-dependent; regulation of gene expression by genetic imprinting; regulation of histone acetylation; regulation of histone methylation; regulation of molecular function, epigenetic; regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog) Ctcf Mus musculus (Mouse) TR36391_c0_g2_i1 Q922K7 NOP2_MOUSE 0 GO:0003723; GO:0008757; GO:0005730; GO:0006364 RNA binding; S-adenosylmethionine-dependent methyltransferase activity; nucleolus; rRNA processing IPR001678; IPR018314; IPR011023; IPR012586; IPR023267; IPR023273; Putative ribosomal RNA methyltransferase NOP2 (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) Nop2 Nol1 Mus musculus (Mouse) TR36393_c4_g4_i1 Q4V7E8 LRRF2_RAT 3.00E-59 GO:0016055 Wnt receptor signaling pathway IPR019139; Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2) Lrrfip2 Rattus norvegicus (Rat) TR36393_c4_g4_i5 Q4V7E8 LRRF2_RAT 2.00E-58 GO:0016055 Wnt receptor signaling pathway IPR019139; Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2) Lrrfip2 Rattus norvegicus (Rat) TR36394_c3_g2_i1 Q8NBH2 KY_HUMAN 4.00E-10 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) KY Homo sapiens (Human) TR36396_c1_g1_i1 Q8K2R5 ZN668_MOUSE 3.00E-27 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 668 Znf668 Zfp668 Mus musculus (Mouse) TR36396_c1_g1_i2 Q9BR84 ZN559_HUMAN 5.00E-20 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 559 ZNF559 Homo sapiens (Human) TR36397_c1_g1_i1 Q498E6 SET8B_XENLA 6.00E-22 GO:0051301; GO:0005694; GO:0018024; GO:0007067; GO:0005634; GO:0006355; GO:0006351 "cell division; chromosome; histone-lysine N-methyltransferase activity; mitosis; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR016858; IPR001214; N-lysine methyltransferase SETD8-B (EC 2.1.1.-) (Histone-lysine N-methyltransferase SETD8-B) (EC 2.1.1.43) (Mitotic phosphoprotein 36) (SET domain-containing protein 8-B) setd8-b mp36 Xenopus laevis (African clawed frog) TR36397_c1_g1_i2 Q08AY6 SET8A_XENLA 2.00E-21 GO:0051301; GO:0005694; GO:0018024; GO:0007067; GO:0005634; GO:0006355; GO:0006351 "cell division; chromosome; histone-lysine N-methyltransferase activity; mitosis; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR016858; IPR001214; N-lysine methyltransferase SETD8-A (EC 2.1.1.-) (Histone-lysine N-methyltransferase SETD8-A) (EC 2.1.1.43) (SET domain-containing protein 8-A) setd8-a Xenopus laevis (African clawed frog) TR36397_c1_g1_i3 Q297V5 SETD8_DROPS 5.00E-14 GO:0051301; GO:0042799; GO:0007067; GO:0005634; GO:0005700; GO:0006355; GO:0006351 "cell division; histone methyltransferase activity (H4-K20 specific); mitosis; nucleus; polytene chromosome; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR016858; IPR001214; Histone-lysine N-methyltransferase pr-set7 (EC 2.1.1.43) (PR/SET domain-containing protein 07) pr-set7 GA17259 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR36397_c1_g1_i5 Q498E6 SET8B_XENLA 8.00E-22 GO:0051301; GO:0005694; GO:0018024; GO:0007067; GO:0005634; GO:0006355; GO:0006351 "cell division; chromosome; histone-lysine N-methyltransferase activity; mitosis; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR016858; IPR001214; N-lysine methyltransferase SETD8-B (EC 2.1.1.-) (Histone-lysine N-methyltransferase SETD8-B) (EC 2.1.1.43) (Mitotic phosphoprotein 36) (SET domain-containing protein 8-B) setd8-b mp36 Xenopus laevis (African clawed frog) TR36397_c1_g4_i3 Q9UIU6 SIX4_HUMAN 1.00E-91 GO:0009653; GO:0048701; GO:0048699; GO:0042472; GO:0072075; GO:0051451; GO:0043524; GO:0005634; GO:0090190; GO:0045944; GO:0072107; GO:0072095; GO:0032880; GO:0008582; GO:0043565; GO:0003700; GO:0007519; GO:0048538 anatomical structure morphogenesis; embryonic cranial skeleton morphogenesis; generation of neurons; inner ear morphogenesis; metanephric mesenchyme development; myoblast migration; negative regulation of neuron apoptotic process; nucleus; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of ureteric bud formation; regulation of branch elongation involved in ureteric bud branching; regulation of protein localization; regulation of synaptic growth at neuromuscular junction; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; skeletal muscle tissue development; thymus development IPR017970; IPR001356; IPR009057; Homeobox protein SIX4 (Sine oculis homeobox homolog 4) SIX4 Homo sapiens (Human) TR36397_c1_g4_i4 Q9UIU6 SIX4_HUMAN 1.00E-74 GO:0009653; GO:0048701; GO:0048699; GO:0042472; GO:0072075; GO:0051451; GO:0043524; GO:0005634; GO:0090190; GO:0045944; GO:0072107; GO:0072095; GO:0032880; GO:0008582; GO:0043565; GO:0003700; GO:0007519; GO:0048538 anatomical structure morphogenesis; embryonic cranial skeleton morphogenesis; generation of neurons; inner ear morphogenesis; metanephric mesenchyme development; myoblast migration; negative regulation of neuron apoptotic process; nucleus; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of ureteric bud formation; regulation of branch elongation involved in ureteric bud branching; regulation of protein localization; regulation of synaptic growth at neuromuscular junction; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; skeletal muscle tissue development; thymus development IPR017970; IPR001356; IPR009057; Homeobox protein SIX4 (Sine oculis homeobox homolog 4) SIX4 Homo sapiens (Human) TR36398_c0_g2_i1 O97772 CCKAR_RABIT 5.00E-08 GO:0004951; GO:0038188; GO:0016021; GO:0005886 cholecystokinin receptor activity; cholecystokinin signaling pathway; integral to membrane; plasma membrane IPR009126; IPR000596; IPR015276; IPR000276; IPR017452; Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR Oryctolagus cuniculus (Rabbit) TR36398_c0_g2_i3 O57422 OPN4B_XENLA 3.00E-06 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR027430; Melanopsin-B (Opsin-4B) (xMOP) opn4b mop Xenopus laevis (African clawed frog) TR36398_c0_g2_i5 O08786 CCKAR_MOUSE 2.00E-08 GO:0007409; GO:0004951; GO:0038188; GO:0030900; GO:0016021; GO:0001764; GO:0005886 axonogenesis; cholecystokinin receptor activity; cholecystokinin signaling pathway; forebrain development; integral to membrane; neuron migration; plasma membrane IPR009126; IPR000596; IPR015276; IPR000276; IPR017452; Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) Cckar Mus musculus (Mouse) TR36399_c3_g1_i1 Q71RS6 NCKX5_HUMAN 2.00E-44 GO:0015297; GO:0006816; GO:0016021; GO:0006811; GO:0042470; GO:0005886; GO:0006813; GO:0050896; GO:0006814; GO:0015293; GO:0055085 antiporter activity; calcium ion transport; integral to membrane; ion transport; melanosome; plasma membrane; potassium ion transport; response to stimulus; sodium ion transport; symporter activity; transmembrane transport IPR004481; IPR004837; Sodium/potassium/calcium exchanger 5 (Na(+)/K(+)/Ca(2+)-exchange protein 5) (Solute carrier family 24 member 5) SLC24A5 JSX NCKX5 Homo sapiens (Human) TR36399_c7_g2_i1 Q2PW47 MED24_DANRE 1.00E-89 GO:0048484; GO:0005634; GO:0006355; GO:0046549; GO:0048538; GO:0006351 "enteric nervous system development; nucleus; regulation of transcription, DNA-dependent; retinal cone cell development; thymus development; transcription, DNA-dependent" IPR021429; Mediator of RNA polymerase II transcription subunit 24 (Mediator complex subunit 24) (Protein lessen) (Thyroid hormone receptor-associated protein 4 homolog) (Trap100 homolog) med24 lsn thrap4 trap100 Danio rerio (Zebrafish) (Brachydanio rerio) TR364_c0_g1_i1 Q9NRA2 S17A5_HUMAN 2.00E-11 GO:0006865; GO:0030054; GO:0005887; GO:0005765; GO:0015136; GO:0015739; GO:0005351; GO:0030672 amino acid transport; cell junction; integral to plasma membrane; lysosomal membrane; sialic acid transmembrane transporter activity; sialic acid transport; sugar:hydrogen symporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) TR36400_c1_g2_i2 Q05713 CRYAB_CHICK 2.00E-13 GO:0030018; GO:0060561; GO:0005829; GO:0002088; GO:0046872; GO:0005739; GO:0007517; GO:0043066; GO:0043154; GO:0010629; GO:0032387; GO:0005634; GO:0005886; GO:0042803; GO:0051260; GO:0042542; GO:0001666; GO:0005212; GO:0007021 Z disc; apoptotic process involved in morphogenesis; cytosol; lens development in camera-type eye; metal ion binding; mitochondrion; muscle organ development; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of gene expression; negative regulation of intracellular transport; nucleus; plasma membrane; protein homodimerization activity; protein homooligomerization; response to hydrogen peroxide; response to hypoxia; structural constituent of eye lens; tubulin complex assembly IPR002068; IPR001436; IPR012273; IPR003090; IPR008978; Alpha-crystallin B chain (Alpha(B)-crystallin) CRYAB Gallus gallus (Chicken) TR36400_c1_g2_i3 Q3T149 HSPB1_BOVIN 3.00E-13 GO:0005737; GO:0005634; GO:0006950; GO:0005819 cytoplasm; nucleus; response to stress; spindle IPR002068; IPR001436; IPR008978; Heat shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27) HSPB1 HSP27 Bos taurus (Bovine) TR36401_c4_g1_i2 Q14657 LAGE3_HUMAN 1.00E-14 IPR015419; EKC/KEOPS complex subunit LAGE3 (L antigen family member 3) (Protein ESO-3) (Protein ITBA2) LAGE3 DXS9879E ESO3 ITBA2 Homo sapiens (Human) TR36401_c4_g1_i3 Q9CR70 LAGE3_MOUSE 6.00E-13 IPR015419; EKC/KEOPS complex subunit Lage3 (ITBA2 protein homolog) (L antigen family member 3) Lage3 Itba2 Mus musculus (Mouse) TR36402_c2_g1_i1 Q6DKP5 WDR13_PANTR 3.00E-64 GO:0005634 nucleus IPR015943; IPR001680; IPR017986; WD repeat-containing protein 13 WDR13 Pan troglodytes (Chimpanzee) TR36402_c4_g1_i2 Q91V09 WDR13_MOUSE 3.00E-107 GO:0005737; GO:0005634 cytoplasm; nucleus IPR015943; IPR001680; IPR017986; WD repeat-containing protein 13 Wdr13 Mus musculus (Mouse) TR36403_c0_g1_i2 O14495 LPP3_HUMAN 3.00E-28 GO:0005794; GO:0005912; GO:0001568; GO:0044329; GO:0044328; GO:0044330; GO:0001702; GO:0008354; GO:0034109; GO:0016021; GO:0042577; GO:0001933; GO:0008195; GO:0006644; GO:0004721; GO:0005886; GO:0050731; GO:0051091; GO:0050821; GO:0030111; GO:0044281; GO:0030148 Golgi apparatus; adherens junction; blood vessel development; canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion; canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration; canonical Wnt receptor signaling pathway involved in positive regulation of wound healing; gastrulation with mouth forming second; germ cell migration; homotypic cell-cell adhesion; integral to membrane; lipid phosphatase activity; negative regulation of protein phosphorylation; phosphatidate phosphatase activity; phospholipid metabolic process; phosphoprotein phosphatase activity; plasma membrane; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of sequence-specific DNA binding transcription factor activity; protein stabilization; regulation of Wnt receptor signaling pathway; small molecule metabolic process; sphingolipid biosynthetic process IPR000326; Lipid phosphate phosphohydrolase 3 (EC 3.1.3.4) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) (Vascular endothelial growth factor and type I collagen-inducible protein) (VCIP) PPAP2B LPP3 Homo sapiens (Human) TR36405_c1_g1_i1 P09628 ACHD_XENLA 1.00E-29 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit delta chnrd Xenopus laevis (African clawed frog) TR36406_c4_g3_i2 Q64604 PTPRF_RAT 1.00E-30 GO:0005768; GO:0060076; GO:0030426; GO:0008201; GO:0007156; GO:0005158; GO:0016021; GO:0031345; GO:0008285; GO:0001960; GO:0042059; GO:0046627; GO:0051387; GO:0043025; GO:0042301; GO:0005886; GO:0050775; GO:0043525; GO:0050803; GO:0005001 endosome; excitatory synapse; growth cone; heparin binding; homophilic cell adhesion; insulin receptor binding; integral to membrane; negative regulation of cell projection organization; negative regulation of cell proliferation; negative regulation of cytokine-mediated signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of neurotrophin TRK receptor signaling pathway; neuronal cell body; phosphate ion binding; plasma membrane; positive regulation of dendrite morphogenesis; positive regulation of neuron apoptotic process; regulation of synapse structure and activity; transmembrane receptor protein tyrosine phosphatase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) Ptprf Lar Rattus norvegicus (Rat) TR36406_c4_g3_i3 A6BM72 MEG11_HUMAN 2.00E-28 GO:0016323; GO:0034109; GO:0016021; GO:0010842 basolateral plasma membrane; homotypic cell-cell adhesion; integral to membrane; retina layer formation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) TR36406_c4_g3_i5 Q64604 PTPRF_RAT 2.00E-30 GO:0005768; GO:0060076; GO:0030426; GO:0008201; GO:0007156; GO:0005158; GO:0016021; GO:0031345; GO:0008285; GO:0001960; GO:0042059; GO:0046627; GO:0051387; GO:0043025; GO:0042301; GO:0005886; GO:0050775; GO:0043525; GO:0050803; GO:0005001 endosome; excitatory synapse; growth cone; heparin binding; homophilic cell adhesion; insulin receptor binding; integral to membrane; negative regulation of cell projection organization; negative regulation of cell proliferation; negative regulation of cytokine-mediated signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of neurotrophin TRK receptor signaling pathway; neuronal cell body; phosphate ion binding; plasma membrane; positive regulation of dendrite morphogenesis; positive regulation of neuron apoptotic process; regulation of synapse structure and activity; transmembrane receptor protein tyrosine phosphatase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) Ptprf Lar Rattus norvegicus (Rat) TR36407_c3_g1_i1 Q80YA3 DDHD1_MOUSE 1.00E-08 GO:0005737; GO:0016787; GO:0016042; GO:0046872 cytoplasm; hydrolase activity; lipid catabolic process; metal ion binding IPR004177; Phospholipase DDHD1 (EC 3.1.1.-) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) Ddhd1 Mus musculus (Mouse) TR36407_c5_g1_i2 P43125 RDGB_DROME 2.00E-111 GO:0005388; GO:0016059; GO:0005887; GO:0046872; GO:0008525; GO:0046488; GO:0008526; GO:0016056; GO:0007608; GO:0016029; GO:0007601 calcium-transporting ATPase activity; deactivation of rhodopsin mediated signaling; integral to plasma membrane; metal ion binding; phosphatidylcholine transporter activity; phosphatidylinositol metabolic process; phosphatidylinositol transporter activity; rhodopsin mediated signaling pathway; sensory perception of smell; subrhabdomeral cisterna; visual perception IPR004177; IPR023214; IPR013209; IPR001666; IPR023393; Protein retinal degeneration B (Probable calcium transporter rdgB) rdgB CG11111 Drosophila melanogaster (Fruit fly) TR36407_c5_g1_i3 P43125 RDGB_DROME 1.00E-81 GO:0005388; GO:0016059; GO:0005887; GO:0046872; GO:0008525; GO:0046488; GO:0008526; GO:0016056; GO:0007608; GO:0016029; GO:0007601 calcium-transporting ATPase activity; deactivation of rhodopsin mediated signaling; integral to plasma membrane; metal ion binding; phosphatidylcholine transporter activity; phosphatidylinositol metabolic process; phosphatidylinositol transporter activity; rhodopsin mediated signaling pathway; sensory perception of smell; subrhabdomeral cisterna; visual perception IPR004177; IPR023214; IPR013209; IPR001666; IPR023393; Protein retinal degeneration B (Probable calcium transporter rdgB) rdgB CG11111 Drosophila melanogaster (Fruit fly) TR36408_c1_g3_i2 Q0IHQ9 ACPL2_XENTR 5.00E-15 GO:0003993; GO:0005576 acid phosphatase activity; extracellular region IPR000560; Acid phosphatase-like protein 2 (EC 3.1.3.2) acpl2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36409_c2_g1_i1 P17972 KCNAW_DROME 1.00E-27 GO:0005251; GO:0051260; GO:0030431; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; sleep; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR015572; IPR003131; IPR028325; Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) TR36409_c2_g1_i2 Q61423 KCNA4_MOUSE 8.00E-25 GO:0016020; GO:0030955; GO:0051260; GO:0005249; GO:0008076 membrane; potassium ion binding; protein homooligomerization; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003972; IPR020467; IPR012897; IPR003131; IPR028325; Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) Kcna4 Mus musculus (Mouse) TR36409_c2_g2_i1 P48547 KCNC1_HUMAN 8.00E-70 GO:0005251; GO:0051260; GO:0007268; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; synaptic transmission; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR005403; IPR003131; IPR028325; Potassium voltage-gated channel subfamily C member 1 (NGK2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4) KCNC1 Homo sapiens (Human) TR36409_c2_g2_i2 Q63959 KCNC3_MOUSE 4.00E-41 GO:0030673; GO:0043679; GO:0005251; GO:0032590; GO:0031594; GO:0032809; GO:0051260; GO:0046928; GO:0008076 axolemma; axon terminus; delayed rectifier potassium channel activity; dendrite membrane; neuromuscular junction; neuronal cell body membrane; protein homooligomerization; regulation of neurotransmitter secretion; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR005404; IPR003131; IPR028325; Potassium voltage-gated channel subfamily C member 3 (KSHIIID) (Voltage-gated potassium channel subunit Kv3.3) Kcnc3 Mus musculus (Mouse) TR36410_c0_g1_i1 Q4R6Y6 SNPC3_MACFA 4.00E-80 GO:0003677; GO:0005634; GO:0006355; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR022042; snRNA-activating protein complex subunit 3 (SNAPc subunit 3) (Small nuclear RNA-activating complex polypeptide 3) SNAPC3 QtsA-16848 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR36412_c0_g1_i1 Q92035 ACES_BUNFA 5.00E-64 GO:0001507; GO:0003990; GO:0004091; GO:0030054; GO:0005576; GO:0005886; GO:0045202 acetylcholine catabolic process in synaptic cleft; acetylcholinesterase activity; carboxylesterase activity; cell junction; extracellular region; plasma membrane; synapse IPR014788; IPR000908; IPR002018; IPR019826; IPR019819; IPR000997; Acetylcholinesterase (AChE) (EC 3.1.1.7) ACHE Bungarus fasciatus (Banded krait) TR36412_c0_g1_i3 P06276 CHLE_HUMAN 2.00E-62 GO:0003990; GO:0001540; GO:0004091; GO:0044267; GO:0019695; GO:0050783; GO:0005788; GO:0019899; GO:0005615; GO:0016020; GO:0005641; GO:0007271 Itself "acetylcholinesterase activity; beta-amyloid binding; carboxylesterase activity; cellular protein metabolic process; choline metabolic process; cocaine metabolic process; endoplasmic reticulum lumen; enzyme binding; extracellular space; membrane; nuclear envelope lumen; synaptic transmission, cholinergic" IPR014788; IPR002018; IPR019826; IPR019819; IPR000997; Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase) BCHE CHE1 Homo sapiens (Human) TR36412_c0_g1_i4 Q92035 ACES_BUNFA 5.00E-63 GO:0001507; GO:0003990; GO:0004091; GO:0030054; GO:0005576; GO:0005886; GO:0045202 acetylcholine catabolic process in synaptic cleft; acetylcholinesterase activity; carboxylesterase activity; cell junction; extracellular region; plasma membrane; synapse IPR014788; IPR000908; IPR002018; IPR019826; IPR019819; IPR000997; Acetylcholinesterase (AChE) (EC 3.1.1.7) ACHE Bungarus fasciatus (Banded krait) TR36413_c3_g1_i1 Q5XK91 FBCDB_XENLA 5.00E-39 GO:0008061; GO:0016021; GO:0046872 chitin binding; integral to membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1-B fibcd1-b Xenopus laevis (African clawed frog) TR36413_c3_g1_i4 Q00546 TENR_CHICK 6.00E-38 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR013032; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin-R (TN-R) (Restrictin) TNR Gallus gallus (Chicken) TR36413_c3_g1_i5 Q5XK91 FBCDB_XENLA 2.00E-39 GO:0008061; GO:0016021; GO:0046872 chitin binding; integral to membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1-B fibcd1-b Xenopus laevis (African clawed frog) TR36414_c3_g4_i3 Q96K80 ZC3HA_HUMAN 3.00E-65 GO:0046872 P54253 metal ion binding IPR000571; Zinc finger CCCH domain-containing protein 10 ZC3H10 ZC3HDC10 Homo sapiens (Human) TR36414_c3_g4_i4 Q96K80 ZC3HA_HUMAN 5.00E-65 GO:0046872 P54253 metal ion binding IPR000571; Zinc finger CCCH domain-containing protein 10 ZC3H10 ZC3HDC10 Homo sapiens (Human) TR36415_c0_g1_i1 Q4R642 TCTE1_MACFA 9.00E-143 T-complex-associated testis-expressed protein 1 (Tcte-1) TCTE1 QtsA-19176 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR36415_c0_g1_i2 Q4R642 TCTE1_MACFA 3.00E-54 T-complex-associated testis-expressed protein 1 (Tcte-1) TCTE1 QtsA-19176 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR36416_c0_g1_i1 Q7T163 KDIS_DANRE 2.00E-11 GO:0016021; GO:0005770; GO:0007399 integral to membrane; late endosome; nervous system development IPR002110; IPR020683; IPR011646; Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) kidins220 arms kidins220b si:dkeyp-7f8.3 si:dz119j18.2 zgc:63531 Danio rerio (Zebrafish) (Brachydanio rerio) TR36416_c0_g1_i2 Q4UMH6 Y381_RICFE 1.00E-09 GO:0015969 guanosine tetraphosphate metabolic process IPR002110; IPR020683; IPR007685; Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR36417_c0_g3_i2 Q29143 ELAC_TRIVU 2.00E-09 GO:0005576; GO:0007595; GO:0004867 extracellular region; lactation; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Early lactation protein ELP Trichosurus vulpecula (Brush-tailed possum) TR36417_c0_g3_i4 P24541 IVBIT_ERIMA 1.00E-11 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Protease inhibitor (Venom trypsin inhibitor) Eristicophis macmahoni (Leaf-nosed viper) TR36417_c0_g4_i1 P86733 KCP_HALAI 2.00E-25 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; BPTI/Kunitz domain-containing protein (Fragment) Haliotis asinina (Donkey's ear abalone) (Ass's ear abalone) TR36417_c0_g4_i2 P10646 TFPI1_HUMAN 1.00E-23 GO:0031225; GO:0007598; GO:0004866; GO:0005783; GO:0005615; GO:0031090; GO:0005886; GO:0004867 "anchored to membrane; blood coagulation, extrinsic pathway; endopeptidase inhibitor activity; endoplasmic reticulum; extracellular space; organelle membrane; plasma membrane; serine-type endopeptidase inhibitor activity" IPR002223; IPR008296; IPR020901; Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI) TFPI LACI TFPI1 Homo sapiens (Human) TR36417_c0_g4_i3 P86733 KCP_HALAI 2.00E-25 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; BPTI/Kunitz domain-containing protein (Fragment) Haliotis asinina (Donkey's ear abalone) (Ass's ear abalone) TR36418_c4_g3_i1 Q6MG06 GNL1_RAT 1.00E-136 GO:0005525; GO:0003924; GO:0005829; GO:0006974; GO:0042254 GTP binding; GTPase activity; cytosol; response to DNA damage stimulus; ribosome biogenesis IPR006073; IPR027417; Guanine nucleotide-binding protein-like 1 Gnl1 Rattus norvegicus (Rat) TR36421_c1_g1_i1 Q96LQ0 PPR36_HUMAN 1.00E-31 GO:0010923; GO:0019902; GO:0004864 negative regulation of phosphatase activity; phosphatase binding; protein phosphatase inhibitor activity IPR026142; Protein phosphatase 1 regulatory subunit 36 PPP1R36 C14orf50 Homo sapiens (Human) TR36422_c5_g1_i1 Q8N468 MFSD4_HUMAN 5.00E-12 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR016196; Major facilitator superfamily domain-containing protein 4 MFSD4 UNQ3064/PRO9894 Homo sapiens (Human) TR36423_c0_g1_i1 P07688 CATB_BOVIN 2.00E-120 GO:0097067; GO:0004197; GO:0005615; GO:0005764; GO:0042470; GO:0005739; GO:0048471; GO:0006508; GO:0050790 cellular response to thyroid hormone stimulus; cysteine-type endopeptidase activity; extracellular space; lysosome; melanosome; mitochondrion; perinuclear region of cytoplasm; proteolysis; regulation of catalytic activity IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR012599; Cathepsin B (EC 3.4.22.1) (BCSB) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] CTSB Bos taurus (Bovine) TR36423_c0_g1_i3 P07688 CATB_BOVIN 2.00E-120 GO:0097067; GO:0004197; GO:0005615; GO:0005764; GO:0042470; GO:0005739; GO:0048471; GO:0006508; GO:0050790 cellular response to thyroid hormone stimulus; cysteine-type endopeptidase activity; extracellular space; lysosome; melanosome; mitochondrion; perinuclear region of cytoplasm; proteolysis; regulation of catalytic activity IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR012599; Cathepsin B (EC 3.4.22.1) (BCSB) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] CTSB Bos taurus (Bovine) TR36424_c5_g1_i2 Q08873 SCP1_YEAST 8.00E-08 GO:0030479; GO:0051015; GO:0007015; GO:0001300; GO:0030674 P15891 "actin cortical patch; actin filament binding; actin filament organization; chronological cell aging; protein binding, bridging" IPR001715; IPR003096; Transgelin (Calponin homolog 1) SCP1 YOR367W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR36424_c5_g1_i3 Q4R5J4 TAGL3_MACFA 1.00E-09 GO:0007517 muscle organ development IPR000557; IPR001715; IPR003096; IPR001061; Transgelin-3 TAGLN3 QflA-12284 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR36424_c5_g1_i5 P37802 TAGL2_HUMAN 2.00E-10 GO:0007517 P60709 muscle organ development IPR000557; IPR001715; IPR003096; IPR001061; Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog) TAGLN2 KIAA0120 CDABP0035 Homo sapiens (Human) TR36424_c5_g1_i6 Q24799 MYPH_ECHGR 1.00E-08 IPR000557; IPR001715; IPR003096; Myophilin Echinococcus granulosus TR36424_c5_g1_i7 P37802 TAGL2_HUMAN 1.00E-09 GO:0007517 P60709 muscle organ development IPR000557; IPR001715; IPR003096; IPR001061; Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog) TAGLN2 KIAA0120 CDABP0035 Homo sapiens (Human) TR36426_c0_g1_i1 Q5ZIZ2 SMYD5_CHICK 1.00E-167 GO:0046872; GO:0008168 metal ion binding; methyltransferase activity IPR001214; IPR002893; SET and MYND domain-containing protein 5 (EC 2.1.1.-) SMYD5 RCJMB04_22j23 Gallus gallus (Chicken) TR36426_c0_g1_i2 Q6GMV2 SMYD5_HUMAN 3.00E-163 GO:0046872; GO:0008168 metal ion binding; methyltransferase activity IPR001214; SET and MYND domain-containing protein 5 (EC 2.1.1.-) (Protein NN8-4AG) (Retinoic acid-induced protein 15) SMYD5 RAI15 Homo sapiens (Human) TR36428_c0_g2_i1 Q86XE5 HOGA1_HUMAN 1.00E-33 GO:0008700; GO:0019470; GO:0009436; GO:0005739; GO:0033609; GO:0042803; GO:0042866 4-hydroxy-2-oxoglutarate aldolase activity; 4-hydroxyproline catabolic process; glyoxylate catabolic process; mitochondrion; oxalate metabolic process; protein homodimerization activity; pyruvate biosynthetic process IPR013785; IPR002220; IPR020625; "4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC 4.1.3.16) (Dihydrodipicolinate synthase-like) (DHDPS-like protein) (Probable 2-keto-4-hydroxyglutarate aldolase) (Probable KHG-aldolase) (Protein 569272)" HOGA1 C10orf65 DHDPSL Homo sapiens (Human) TR36428_c0_g2_i2 A3CVI7 DAPA_METMJ 3.00E-39 GO:0008840; GO:0016843; GO:0005737; GO:0019877; GO:0009089 4-hydroxy-tetrahydrodipicolinate synthase; amine-lyase activity; cytoplasm; diaminopimelate biosynthetic process; lysine biosynthetic process via diaminopimelate IPR013785; IPR005263; IPR002220; IPR020625; IPR020624; Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. 4-hydroxy-tetrahydrodipicolinate synthase (HTPA synthase) (EC 4.3.3.7) dapA Memar_1458 Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) TR36428_c0_g2_i3 Q6NY77 HOGA1_DANRE 9.00E-115 GO:0008700; GO:0009436; GO:0005739 4-hydroxy-2-oxoglutarate aldolase activity; glyoxylate catabolic process; mitochondrion IPR013785; IPR002220; IPR020625; "4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC 4.1.3.16) (Dihydrodipicolinate synthase-like) (DHDPS-like protein) (Probable 2-keto-4-hydroxyglutarate aldolase) (Probable KHG-aldolase)" zgc:77082 Danio rerio (Zebrafish) (Brachydanio rerio) TR36428_c0_g2_i5 Q5V5D4 DAPA_HALMA 4.00E-38 GO:0008840; GO:0016843; GO:0005737; GO:0019877; GO:0009089 4-hydroxy-tetrahydrodipicolinate synthase; amine-lyase activity; cytoplasm; diaminopimelate biosynthetic process; lysine biosynthetic process via diaminopimelate IPR013785; IPR005263; IPR002220; IPR020624; Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. 4-hydroxy-tetrahydrodipicolinate synthase (HTPA synthase) (EC 4.3.3.7) dapA rrnAC0207 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) TR36428_c0_g2_i6 Q5WUD4 DAPA_LEGPL 1.00E-23 GO:0008840; GO:0016843; GO:0005737; GO:0019877; GO:0009089 4-hydroxy-tetrahydrodipicolinate synthase; amine-lyase activity; cytoplasm; diaminopimelate biosynthetic process; lysine biosynthetic process via diaminopimelate IPR013785; IPR005263; IPR002220; IPR020625; IPR020624; Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. 4-hydroxy-tetrahydrodipicolinate synthase (HTPA synthase) (EC 4.3.3.7) dapA lpl2234 Legionella pneumophila (strain Lens) TR36428_c0_g2_i7 Q668F7 DAPA_YERPS 4.00E-25 GO:0008840; GO:0016843; GO:0005737; GO:0019877; GO:0009089 4-hydroxy-tetrahydrodipicolinate synthase; amine-lyase activity; cytoplasm; diaminopimelate biosynthetic process; lysine biosynthetic process via diaminopimelate IPR013785; IPR005263; IPR002220; IPR020625; IPR020624; Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. 4-hydroxy-tetrahydrodipicolinate synthase (HTPA synthase) (EC 4.3.3.7) dapA YPTB2783 Yersinia pseudotuberculosis serotype I (strain IP32953) TR36430_c2_g1_i1 Q53R41 FAKD1_HUMAN 3.00E-19 GO:0045333; GO:0005739; GO:0004672; GO:0006468 cellular respiration; mitochondrion; protein kinase activity; protein phosphorylation IPR013579; IPR010622; IPR013584; FAST kinase domain-containing protein 1 FASTKD1 KIAA1800 Homo sapiens (Human) TR36432_c0_g1_i2 Q9DB27 MCTS1_MOUSE 3.00E-75 GO:0003723; GO:0007049; GO:0005737; GO:0040008; GO:0006355; GO:0006974; GO:0006351 "RNA binding; cell cycle; cytoplasm; regulation of growth; regulation of transcription, DNA-dependent; response to DNA damage stimulus; transcription, DNA-dependent" IPR002478; IPR015947; IPR016437; IPR004521; Malignant T-cell-amplified sequence 1 (MCT-1) (Multiple copies T-cell malignancies 1) Mcts1 Mus musculus (Mouse) TR36434_c1_g1_i1 A4YI89 HPCD_METS5 1.00E-51 GO:0043956; GO:0006631 3-hydroxypropionyl-CoA dehydratase activity; fatty acid metabolic process IPR014748; IPR001753; IPR018376; 3-hydroxypropionyl-coenzyme A dehydratase (3-hydroxypropionyl-CoA dehydratase) (EC 4.2.1.116) Msed_2001 Metallosphaera sedula (strain ATCC 51363 / DSM 5348) TR36434_c1_g1_i2 Q3TLP5 ECHD2_MOUSE 2.00E-101 GO:0006631; GO:0016829; GO:0005739 fatty acid metabolic process; lyase activity; mitochondrion IPR014748; IPR001753; IPR018376; "Enoyl-CoA hydratase domain-containing protein 2, mitochondrial" Echdc2 D4Ertd765e Mus musculus (Mouse) TR36436_c1_g1_i1 Q8TAM2 TTC8_HUMAN 0 GO:0034464; GO:0007411; GO:0060219; GO:0005813; GO:0005929; GO:0042384; GO:0060170; GO:0005737; GO:0048560; GO:0045444; GO:0005932; GO:0035264; GO:0021772; GO:0032391; GO:0032880; GO:0061326; GO:0007608; GO:0050893 Q3SYG4 BBSome; axon guidance; camera-type eye photoreceptor cell differentiation; centrosome; cilium; cilium assembly; cilium membrane; cytoplasm; establishment of anatomical structure orientation; fat cell differentiation; microtubule basal body; multicellular organism growth; olfactory bulb development; photoreceptor connecting cilium; regulation of protein localization; renal tubule development; sensory perception of smell; sensory processing IPR013026; IPR011990; IPR001440; IPR013105; IPR019734; Tetratricopeptide repeat protein 8 (TPR repeat protein 8) (Bardet-Biedl syndrome 8 protein) TTC8 BBS8 Homo sapiens (Human) TR36436_c1_g1_i3 O77033 CYC8_DICDI 1.00E-07 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR013026; IPR011990; IPR001440; IPR019734; General transcriptional corepressor trfA trfA DDB_G0269194 Dictyostelium discoideum (Slime mold) TR36436_c1_g1_i4 Q8TAM2 TTC8_HUMAN 1.00E-72 GO:0034464; GO:0007411; GO:0060219; GO:0005813; GO:0005929; GO:0042384; GO:0060170; GO:0005737; GO:0048560; GO:0045444; GO:0005932; GO:0035264; GO:0021772; GO:0032391; GO:0032880; GO:0061326; GO:0007608; GO:0050893 Q3SYG4 BBSome; axon guidance; camera-type eye photoreceptor cell differentiation; centrosome; cilium; cilium assembly; cilium membrane; cytoplasm; establishment of anatomical structure orientation; fat cell differentiation; microtubule basal body; multicellular organism growth; olfactory bulb development; photoreceptor connecting cilium; regulation of protein localization; renal tubule development; sensory perception of smell; sensory processing IPR013026; IPR011990; IPR001440; IPR013105; IPR019734; Tetratricopeptide repeat protein 8 (TPR repeat protein 8) (Bardet-Biedl syndrome 8 protein) TTC8 BBS8 Homo sapiens (Human) TR36437_c0_g2_i1 Q3TT38 CF106_MOUSE 6.00E-76 IPR009060; Uncharacterized protein C6orf106 homolog D17Wsu92e Mus musculus (Mouse) TR36438_c0_g1_i1 Q5E996 NOP16_BOVIN 2.00E-30 GO:0005730 nucleolus IPR019002; Nucleolar protein 16 NOP16 Bos taurus (Bovine) TR36438_c0_g1_i3 Q6DGI3 NOP16_DANRE 5.00E-19 GO:0005730 nucleolus IPR019002; Nucleolar protein 16 nop16 zgc:92910 Danio rerio (Zebrafish) (Brachydanio rerio) TR36438_c0_g1_i4 Q1RP77 NOP16_RAT 2.00E-29 GO:0005730 nucleolus IPR019002; Nucleolar protein 16 (Protein ZH1) Nop16 Rattus norvegicus (Rat) TR36438_c2_g1_i1 P0DJG4 THEGL_HUMAN 2.00E-24 IPR006623; Testicular haploid expressed gene protein-like (Theg spermatid-like protein) THEGL Homo sapiens (Human) TR36439_c2_g1_i2 Q0VBU9 PPC1A_MOUSE 5.00E-64 GO:0016021; GO:0008195; GO:0046839 integral to membrane; phosphatidate phosphatase activity; phospholipid dephosphorylation IPR000326; Phosphatidate phosphatase PPAPDC1A (EC 3.1.3.4) (Phosphatidic acid phosphatase type 2 domain-containing protein 1A) Ppapdc1a Mus musculus (Mouse) TR36439_c2_g1_i3 Q0VBU9 PPC1A_MOUSE 5.00E-64 GO:0016021; GO:0008195; GO:0046839 integral to membrane; phosphatidate phosphatase activity; phospholipid dephosphorylation IPR000326; Phosphatidate phosphatase PPAPDC1A (EC 3.1.3.4) (Phosphatidic acid phosphatase type 2 domain-containing protein 1A) Ppapdc1a Mus musculus (Mouse) TR36439_c2_g1_i4 Q04396 LPP1_YEAST 1.00E-10 GO:0000139; GO:0016021; GO:0016020; GO:0008195; GO:0006644 Itself; Q12270; P32368; P40107; P25361 Golgi membrane; integral to membrane; membrane; phosphatidate phosphatase activity; phospholipid metabolic process IPR000326; Lipid phosphate phosphatase 1 (EC 3.1.3.-) (Phosphatidate phosphatase) (EC 3.1.3.4) LPP1 YDR503C D9719.9 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR36440_c0_g1_i1 Q9UF56 FXL17_HUMAN 7.00E-75 IPR001810; F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13) FBXL17 FBL17 FBX13 FBXO13 Homo sapiens (Human) TR36440_c0_g1_i2 C8V4D4 GRRA_EMENI 9.00E-28 GO:0019005; GO:0030437; GO:0005737; GO:0031176; GO:0007126 "SCF ubiquitin ligase complex; ascospore formation; cytoplasm; endo-1,4-beta-xylanase activity; meiosis" IPR001810; IPR026940; IPR006553; SCF E3 ubiquitin ligase complex F-box protein grrA (F-box and leucine-rich repeat protein grrA) (F-box/LRR-repeat protein grrA) (SCF substrate adapter protein grrA) grrA grr1 AN10516 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR36440_c0_g1_i5 A1A5X2 FBXL7_DANRE 2.00E-34 GO:0005737; GO:0005815; GO:0016567 cytoplasm; microtubule organizing center; protein ubiquitination IPR001810; IPR006553; Protein modification; protein ubiquitination. F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) fbxl7 zgc:158346 Danio rerio (Zebrafish) (Brachydanio rerio) TR36440_c0_g1_i6 Q8BH16 FBXL2_MOUSE 8.00E-31 GO:0016020; GO:0006513; GO:0006511; GO:0004842 membrane; protein monoubiquitination; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR001810; IPR006553; F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) Fbxl2 Fbl2 Mus musculus (Mouse) TR36440_c0_g1_i7 Q9UF56 FXL17_HUMAN 6.00E-75 IPR001810; F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13) FBXL17 FBL17 FBX13 FBXO13 Homo sapiens (Human) TR36441_c0_g1_i1 Q921D4 MED6_MOUSE 4.00E-85 GO:0003677; GO:0001104; GO:0016592; GO:0045944; GO:0019827; GO:0003713 DNA binding; RNA polymerase II transcription cofactor activity; mediator complex; positive regulation of transcription from RNA polymerase II promoter; stem cell maintenance; transcription coactivator activity IPR007018; IPR016820; Mediator of RNA polymerase II transcription subunit 6 (Mediator complex subunit 6) Med6 Mus musculus (Mouse) TR36441_c0_g1_i2 Q6IQ63 MED6_DANRE 5.00E-84 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR007018; IPR016820; Mediator of RNA polymerase II transcription subunit 6 (Mediator complex subunit 6) med6 zgc:86933 Danio rerio (Zebrafish) (Brachydanio rerio) TR36441_c0_g1_i3 Q6C3T0 MED6_YARLI 1.00E-29 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR007018; IPR016612; Mediator of RNA polymerase II transcription subunit 6 (Mediator complex subunit 6) MED6 YALI0E32373g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR36442_c1_g1_i1 Q8BJI1 S6A17_MOUSE 3.00E-73 GO:0032328; GO:0030054; GO:0015816; GO:0005887; GO:0015820; GO:0005328; GO:0015824; GO:0008021; GO:0030672 alanine transport; cell junction; glycine transport; integral to plasma membrane; leucine transport; neurotransmitter:sodium symporter activity; proline transport; synaptic vesicle; synaptic vesicle membrane IPR000175; IPR002438; Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17) Slc6a17 Ntt4 Mus musculus (Mouse) TR36442_c1_g1_i3 A7Y2W8 SC6A9_XENLA 2.00E-111 GO:0005887; GO:0005328; GO:0005283 integral to plasma membrane; neurotransmitter:sodium symporter activity; sodium:amino acid symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9) slc6a9 glyt1 Xenopus laevis (African clawed frog) TR36443_c4_g1_i1 P29120 NEC1_HUMAN 7.00E-17 GO:0005794; GO:0007267; GO:0044267; GO:0005615; GO:0043043; GO:0016486; GO:0006508; GO:0050796; GO:0034774; GO:0004252; GO:0030133 Golgi apparatus; cell-cell signaling; cellular protein metabolic process; extracellular space; peptide biosynthetic process; peptide hormone processing; proteolysis; regulation of insulin secretion; secretory granule lumen; serine-type endopeptidase activity; transport vesicle IPR008979; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR022005; IPR009020; IPR002884; Neuroendocrine convertase 1 (NEC 1) (EC 3.4.21.93) (Prohormone convertase 1) (Proprotein convertase 1) (PC1) PCSK1 NEC1 Homo sapiens (Human) TR36443_c5_g1_i1 Q9NJ15 PCSK5_BRACL 9.00E-19 GO:0005576; GO:0016021; GO:0005886; GO:0006508; GO:0004252 extracellular region; integral to membrane; plasma membrane; proteolysis; serine-type endopeptidase activity IPR000742; IPR006212; IPR008979; IPR009030; IPR000209; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase PC6-like) (aPC6) PC6 Branchiostoma californiense (California lancelet) (Amphioxus) TR36444_c0_g1_i1 Q6GQ53 PUSL1_XENLA 2.00E-27 GO:0003723; GO:0009982; GO:0001522; GO:0008033 RNA binding; pseudouridine synthase activity; pseudouridine synthesis; tRNA processing IPR020103; IPR001406; IPR020097; IPR020095; IPR020094; tRNA pseudouridine synthase-like 1 (EC 5.4.99.-) (tRNA pseudouridylate synthase-like 1) (tRNA-uridine isomerase-like 1) pusl1 Xenopus laevis (African clawed frog) TR36446_c0_g1_i1 Q3T0V9 DEOC_BOVIN 5.00E-156 GO:0005737; GO:0046121; GO:0009264; GO:0046386; GO:0004139 cytoplasm; deoxyribonucleoside catabolic process; deoxyribonucleotide catabolic process; deoxyribose phosphate catabolic process; deoxyribose-phosphate aldolase activity IPR013785; IPR011343; IPR002915; Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. Putative deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase) DERA Bos taurus (Bovine) TR36448_c0_g1_i2 Q4R4R6 CDC42_MACFA 7.00E-31 GO:0005525; GO:0030154; GO:0005737; GO:0016020; GO:0005815; GO:0030496; GO:0072686; GO:0007399; GO:0005886; GO:0032467; GO:1900026; GO:0051988; GO:0051489; GO:0007264; GO:0051233 GTP binding; cell differentiation; cytoplasm; membrane; microtubule organizing center; midbody; mitotic spindle; nervous system development; plasma membrane; positive regulation of cytokinesis; positive regulation of substrate adhesion-dependent cell spreading; regulation of attachment of spindle microtubules to kinetochore; regulation of filopodium assembly; small GTPase mediated signal transduction; spindle midzone IPR027417; IPR005225; IPR001806; IPR003578; Cell division control protein 42 homolog CDC42 QflA-13723 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR36448_c0_g1_i4 Q24192 RHOL_DROME 4.00E-30 GO:0005525; GO:0003924; GO:0007298; GO:0005509; GO:0007155; GO:0007516; GO:0035099; GO:0005622; GO:0035011; GO:0007498; GO:0005886; GO:0022409; GO:0008360; GO:0006974; GO:0007264 GTP binding; GTPase activity; border follicle cell migration; calcium ion binding; cell adhesion; hemocyte development; hemocyte migration; intracellular; melanotic encapsulation of foreign target; mesoderm development; plasma membrane; positive regulation of cell-cell adhesion; regulation of cell shape; response to DNA damage stimulus; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Ras-like GTP-binding protein RhoL RhoL Drac3 CG9366 Drosophila melanogaster (Fruit fly) TR36453_c1_g2_i1 Q8SSS9 QKGA_DICDI 5.00E-06 GO:0005524; GO:0005525; GO:0005737; GO:0031158; GO:0008285; GO:0006997; GO:0004674; GO:0007264 ATP binding; GTP binding; cytoplasm; negative regulation of aggregate size involved in sorocarp development; negative regulation of cell proliferation; nucleus organization; protein serine/threonine kinase activity; small GTPase mediated signal transduction IPR011009; IPR001611; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR001245; Probable serine/threonine-protein kinase qkgA (EC 2.7.11.1) (Quick growth protein qkgA) (Ras of complex proteins and C-terminal of roc 2) qkgA-1 roco2-1 DDB_G0273259; qkgA-2 roco2-2 DDB_G0273635 Dictyostelium discoideum (Slime mold) TR36453_c1_g2_i2 Q55E58 PATS1_DICDI 1.00E-10 GO:0005524; GO:0005525; GO:0042641; GO:0000281; GO:0004721; GO:0006470; GO:0004674; GO:0007264 ATP binding; GTP binding; actomyosin; mitotic cytokinesis; phosphoprotein phosphatase activity; protein dephosphorylation; protein serine/threonine kinase activity; small GTPase mediated signal transduction IPR011009; IPR001611; IPR013684; IPR010569; IPR017906; IPR027417; IPR000719; IPR011047; IPR020859; IPR001245; IPR008271; IPR005225; IPR001806; IPR015943; IPR001680; IPR017986; Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) TR36453_c1_g2_i4 Q6XHB2 ROCO4_DICDI 3.00E-16 GO:0005524; GO:0005525; GO:0005829; GO:0004672; GO:0004674; GO:0031153; GO:0007264; GO:0031150 ATP binding; GTP binding; cytosol; protein kinase activity; protein serine/threonine kinase activity; slug development involved in sorocarp development; small GTPase mediated signal transduction; sorocarp stalk development IPR011009; IPR001611; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR001245; IPR015943; IPR001680; IPR017986; Probable serine/threonine-protein kinase roco4 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 4) roco4 DDB_G0288251 Dictyostelium discoideum (Slime mold) TR36453_c1_g2_i7 Q1ZXD6 ROCO5_DICDI 1.00E-12 GO:0005524; GO:0005525; GO:0005089; GO:0005622; GO:0005543; GO:0004674; GO:0035023; GO:0007264; GO:0030587 ATP binding; GTP binding; Rho guanyl-nucleotide exchange factor activity; intracellular; phospholipid binding; protein serine/threonine kinase activity; regulation of Rho protein signal transduction; small GTPase mediated signal transduction; sorocarp development IPR000219; IPR011009; IPR001611; IPR025875; IPR003591; IPR013684; IPR027417; IPR011993; IPR001849; IPR000719; IPR017441; IPR020859; IPR001245; IPR008271; IPR001806; Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) TR36453_c1_g2_i8 Q5S007 LRRK2_HUMAN 1.00E-09 GO:0005524; GO:0005525; GO:0034211; GO:0005096; GO:0003924; GO:0004708; GO:0000186; GO:0006914; GO:0032839; GO:0008340; GO:0035640; GO:0032473; GO:0048312; GO:0045121; GO:0034260; GO:2000173; GO:0061002; GO:0007406; GO:0014043; GO:0007528; GO:0070997; GO:0043025; GO:0018105; GO:0018107; GO:0005886; GO:0010508; GO:0060161; GO:0043068; GO:0032436; GO:0031398; GO:0046777; GO:0035564; GO:0040012; GO:0042391; GO:0006979; GO:0007264; GO:0008021; GO:0022028; GO:0005802; GO:0015631 Itself; Q9UKV8; P31749; Q8N6T3-2; Q62848; Q14155; Q16543; P60953; P30275; P53355; O00429; O00429-3; O14640-2; O14641; Q92997; Q13158; P11142; O75581; Q38SD2; P46734; P52564; O14733; P10636-8; P02687; P26038; Q13469; O60260; P30048; P61020; P61021; Q63481; P63000; Q99962; P37840; Q58A65; P31946; P62258; P61981; Q04917; P27348; P63104 ATP binding; GTP binding; GTP-dependent protein kinase activity; GTPase activator activity; GTPase activity; MAP kinase kinase activity; activation of MAPKK activity; autophagy; dendrite cytoplasm; determination of adult lifespan; exploration behavior; external side of mitochondrial outer membrane; intracellular distribution of mitochondria; membrane raft; negative regulation of GTPase activity; negative regulation of branching morphogenesis of a nerve; negative regulation of dendritic spine morphogenesis; negative regulation of neuroblast proliferation; negative regulation of neuron maturation; neuromuscular junction development; neuron death; neuronal cell body; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; plasma membrane; positive regulation of autophagy; positive regulation of dopamine receptor signaling pathway; positive regulation of programmed cell death; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; protein autophosphorylation; regulation of kidney size; regulation of locomotion; regulation of membrane potential; response to oxidative stress; small GTPase mediated signal transduction; synaptic vesicle; tangential migration from the subventricular zone to the olfactory bulb; trans-Golgi network; tubulin binding IPR020683; IPR011989; IPR016024; IPR011009; IPR001611; IPR025875; IPR003591; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR008271; IPR005225; IPR001806; IPR015943; IPR001680; IPR017986; Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin) LRRK2 PARK8 Homo sapiens (Human) TR36453_c1_g2_i9 Q6XHB2 ROCO4_DICDI 2.00E-15 GO:0005524; GO:0005525; GO:0005829; GO:0004672; GO:0004674; GO:0031153; GO:0007264; GO:0031150 ATP binding; GTP binding; cytosol; protein kinase activity; protein serine/threonine kinase activity; slug development involved in sorocarp development; small GTPase mediated signal transduction; sorocarp stalk development IPR011009; IPR001611; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR001245; IPR015943; IPR001680; IPR017986; Probable serine/threonine-protein kinase roco4 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 4) roco4 DDB_G0288251 Dictyostelium discoideum (Slime mold) TR36454_c0_g1_i1 Q8NCA9 ZN784_HUMAN 1.00E-16 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 784 ZNF784 Homo sapiens (Human) TR36454_c0_g2_i1 Q9HAZ2 PRD16_HUMAN 5.00E-79 GO:0050873; GO:0046872; GO:0030853; GO:0000122; GO:0030512; GO:0022008; GO:0060021; GO:0045893; GO:0043457; GO:0043565; GO:0035019; GO:0043586; GO:0003713; GO:0006351; GO:0017053; GO:0050872 P56546 "brown fat cell differentiation; metal ion binding; negative regulation of granulocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; neurogenesis; palate development; positive regulation of transcription, DNA-dependent; regulation of cellular respiration; sequence-specific DNA binding; somatic stem cell maintenance; tongue development; transcription coactivator activity; transcription, DNA-dependent; transcriptional repressor complex; white fat cell differentiation" IPR001214; IPR007087; IPR015880; IPR013087; PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) PRDM16 KIAA1675 MEL1 PFM13 Homo sapiens (Human) TR36455_c2_g2_i3 Q9VA02 DHTK1_DROME 1.00E-18 GO:0006091; GO:0006096; GO:0031966; GO:0004591; GO:0030976; GO:0006099 generation of precursor metabolites and energy; glycolysis; mitochondrial membrane; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding; tricarboxylic acid cycle IPR011603; IPR001017; IPR005475; "Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial (EC 1.2.4.2)" CG1544 Drosophila melanogaster (Fruit fly) TR36455_c2_g2_i5 Q9VA02 DHTK1_DROME 1.00E-19 GO:0006091; GO:0006096; GO:0031966; GO:0004591; GO:0030976; GO:0006099 generation of precursor metabolites and energy; glycolysis; mitochondrial membrane; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding; tricarboxylic acid cycle IPR011603; IPR001017; IPR005475; "Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial (EC 1.2.4.2)" CG1544 Drosophila melanogaster (Fruit fly) TR36456_c0_g3_i1 P18910 ANPRA_RAT 2.00E-72 GO:0005524; GO:0005525; GO:0007166; GO:0042417; GO:0004383; GO:0016021; GO:0035556; GO:0016941; GO:0048662; GO:0017046; GO:0005886; GO:0030828; GO:0004672; GO:0019901; GO:0007168; GO:0050880 ATP binding; GTP binding; cell surface receptor signaling pathway; dopamine metabolic process; guanylate cyclase activity; integral to membrane; intracellular signal transduction; natriuretic peptide receptor activity; negative regulation of smooth muscle cell proliferation; peptide hormone binding; plasma membrane; positive regulation of cGMP biosynthetic process; protein kinase activity; protein kinase binding; receptor guanylyl cyclase signaling pathway; regulation of blood vessel size IPR001054; IPR018297; IPR001828; IPR011009; IPR001170; IPR028082; IPR000719; IPR001245; Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) Npr1 Rattus norvegicus (Rat) TR36456_c0_g3_i2 P70180 ANPRC_MOUSE 1.00E-66 GO:0042562; GO:0016021; GO:0016941; GO:0002158; GO:0035810; GO:0008217; GO:0033688; GO:0001501 hormone binding; integral to membrane; natriuretic peptide receptor activity; osteoclast proliferation; positive regulation of urine volume; regulation of blood pressure; regulation of osteoblast proliferation; skeletal system development IPR001828; IPR001170; IPR028082; Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C) (EF-2) Npr3 Mus musculus (Mouse) TR36456_c0_g3_i4 Q07553 GCY3E_DROME 2.00E-12 GO:0005524; GO:0005525; GO:0004383; GO:0005887; GO:0035556; GO:0004872; GO:0016772 "ATP binding; GTP binding; guanylate cyclase activity; integral to plasma membrane; intracellular signal transduction; receptor activity; transferase activity, transferring phosphorus-containing groups" IPR001054; IPR018297; IPR001828; IPR011009; IPR028082; IPR000719; IPR001245; Guanylate cyclase 32E (EC 4.6.1.2) Gyc32E GC CG33114 Drosophila melanogaster (Fruit fly) TR36457_c0_g1_i1 A9ULZ2 BIR7B_XENLA 1.00E-19 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) TR36457_c0_g1_i2 Q5BKL8 XIAP_XENTR 2.00E-21 GO:0016055; GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0045861; GO:0008270 Wnt receptor signaling pathway; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; negative regulation of proteolysis; zinc ion binding IPR001370; IPR001841; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (X-linked inhibitor of apoptosis protein) (X-linked IAP) xiap birc4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36457_c0_g3_i1 Q8JHV9 BIR7A_XENLA 6.00E-25 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR36458_c0_g1_i1 Q02630 NU116_YEAST 7.00E-10 GO:0031965; GO:0044613; GO:0044614; GO:0006999; GO:0005487; GO:0016973; GO:0006606; GO:0000055; GO:0017056; GO:0006409 Itself; Q12453; P40066; Q06142; Q99257; Q02629; P49686; P48837; P40368 nuclear membrane; nuclear pore central transport channel; nuclear pore cytoplasmic filaments; nuclear pore organization; nucleocytoplasmic transporter activity; poly(A)+ mRNA export from nucleus; protein import into nucleus; ribosomal large subunit export from nucleus; structural constituent of nuclear pore; tRNA export from nucleus IPR025574; IPR007230; Nucleoporin NUP116/NSP116 (Nuclear pore protein NUP116/NSP116) NUP116 NSP116 YMR047C YM9532.12C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR36459_c5_g1_i1 P35541 SAA_BOVIN 6.00E-11 GO:0006953; GO:0034364 acute-phase response; high-density lipoprotein particle IPR000096; Serum amyloid A protein (SAA) [Cleaved into: Amyloid protein A (Amyloid fibril protein AA)] SAA1 SAA Bos taurus (Bovine) TR36460_c0_g1_i3 Q8BTF8 RALYL_MOUSE 2.00E-23 GO:0003723; GO:0000166 RNA binding; nucleotide binding IPR017347; IPR012677; IPR000504; RNA-binding Raly-like protein Ralyl Mus musculus (Mouse) TR36460_c0_g1_i4 P19600 HNRPC_XENLA 2.00E-25 GO:0003723; GO:0000166; GO:0005634; GO:0030529; GO:0038032 RNA binding; nucleotide binding; nucleus; ribonucleoprotein complex; termination of G-protein coupled receptor signaling pathway IPR017347; IPR012677; IPR016137; IPR000504; Heterogeneous nuclear ribonucleoprotein C (hnRNP C) (hnRNP core protein C) hnrnpc hnrpc Xenopus laevis (African clawed frog) TR36460_c0_g1_i6 Q08DJ0 RALYL_BOVIN 3.00E-25 GO:0003723; GO:0000166 RNA binding; nucleotide binding IPR017347; IPR012677; IPR000504; RNA-binding Raly-like protein RALYL Bos taurus (Bovine) TR36460_c0_g1_i7 P19600 HNRPC_XENLA 1.00E-24 GO:0003723; GO:0000166; GO:0005634; GO:0030529; GO:0038032 RNA binding; nucleotide binding; nucleus; ribonucleoprotein complex; termination of G-protein coupled receptor signaling pathway IPR017347; IPR012677; IPR016137; IPR000504; Heterogeneous nuclear ribonucleoprotein C (hnRNP C) (hnRNP core protein C) hnrnpc hnrpc Xenopus laevis (African clawed frog) TR36463_c3_g1_i1 Q86VH2 KIF27_HUMAN 2.00E-38 GO:0005524; GO:0005929; GO:0042384; GO:0005737; GO:0003351; GO:0005871; GO:0005874; GO:0003777; GO:0021591 ATP binding; cilium; cilium assembly; cytoplasm; epithelial cilium movement; kinesin complex; microtubule; microtubule motor activity; ventricular system development IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF27 KIF27 Homo sapiens (Human) TR36463_c4_g1_i1 P87053 POF1_SCHPO 5.00E-19 GO:0019005; GO:0071276; GO:0005634; GO:0042787; GO:0007346 Q9Y709 SCF ubiquitin ligase complex; cellular response to cadmium ion; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of mitotic cell cycle IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein pof1 (Skp1-binding protein 1) pof1 sbp1 SPAC57A10.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36463_c4_g1_i2 Q7Z4S6 KI21A_HUMAN 3.00E-111 GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0007018 Q9Y6D6; Q14678; Q14678-2 ATP binding; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement IPR027640; IPR019821; IPR001752; IPR027417; IPR009053; IPR015943; IPR001680; IPR019775; IPR017986; Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) KIF21A KIAA1708 KIF2 Homo sapiens (Human) TR36463_c4_g1_i3 Q9QXL2 KI21A_MOUSE 5.00E-110 GO:0005524; GO:0030424; GO:0005737; GO:0030425; GO:0005871; GO:0005874; GO:0003777; GO:0007018 ATP binding; axon; cytoplasm; dendrite; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement IPR027640; IPR019821; IPR001752; IPR027417; IPR009053; IPR015943; IPR001680; IPR019775; IPR017986; Kinesin-like protein KIF21A Kif21a Kiaa1708 Mus musculus (Mouse) TR36464_c0_g1_i1 F1M7Y5 KPCI_RAT 0 GO:0005524; GO:0048194; GO:0043220; GO:0031252; GO:0016477; GO:0045216; GO:0034613; GO:0032869; GO:0005829; GO:0005768; GO:0035556; GO:0034351; GO:0043524; GO:0005634; GO:0005543; GO:0005886; GO:0051092; GO:2000353; GO:0090004; GO:0060252; GO:0046326; GO:0010976; GO:0043234; GO:0004697; GO:0070555; GO:0008270 ATP binding; Golgi vesicle budding; Schmidt-Lanterman incisure; cell leading edge; cell migration; cell-cell junction organization; cellular protein localization; cellular response to insulin stimulus; cytosol; endosome; intracellular signal transduction; negative regulation of glial cell apoptotic process; negative regulation of neuron apoptotic process; nucleus; phospholipid binding; plasma membrane; positive regulation of NF-kappaB transcription factor activity; positive regulation of endothelial cell apoptotic process; positive regulation of establishment of protein localization to plasma membrane; positive regulation of glial cell proliferation; positive regulation of glucose import; positive regulation of neuron projection development; protein complex; protein kinase C activity; response to interleukin-1; zinc ion binding IPR000961; IPR020454; IPR011009; IPR000270; IPR012233; IPR017892; IPR002219; IPR000719; IPR017441; IPR002290; IPR008271; Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) Prkci Pkcl Rattus norvegicus (Rat) TR36464_c0_g1_i2 Q1LZ97 GRP4_BOVIN 2.00E-06 GO:0005088; GO:0005509; GO:0030154; GO:0016049; GO:0008283; GO:0005737; GO:0016020; GO:0005634; GO:0005886; GO:0046579; GO:0009991; GO:0007264 Ras guanyl-nucleotide exchange factor activity; calcium ion binding; cell differentiation; cell growth; cell proliferation; cytoplasm; membrane; nucleus; plasma membrane; positive regulation of Ras protein signal transduction; response to extracellular stimulus; small GTPase mediated signal transduction IPR020454; IPR002048; IPR002219; IPR000651; IPR008937; IPR023578; IPR001895; RAS guanyl-releasing protein 4 RASGRP4 Bos taurus (Bovine) TR36464_c0_g1_i3 Q8IV61 GRP3_HUMAN 4.00E-08 GO:0000165; GO:0046582; GO:0005088; GO:0007265; GO:0005509; GO:0019992; GO:0005085; GO:0032045; GO:0005887; GO:0048471; GO:0004871; GO:0007264 MAPK cascade; Rap GTPase activator activity; Ras guanyl-nucleotide exchange factor activity; Ras protein signal transduction; calcium ion binding; diacylglycerol binding; guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor complex; integral to plasma membrane; perinuclear region of cytoplasm; signal transducer activity; small GTPase mediated signal transduction IPR020454; IPR011992; IPR018247; IPR002048; IPR002219; IPR000651; IPR008937; IPR023578; IPR001895; Ras guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1) RASGRP3 GRP3 KIAA0846 Homo sapiens (Human) TR36466_c1_g1_i2 Q9GZS1 RPA49_HUMAN 8.00E-44 GO:0003677; GO:0003899; GO:0030054; GO:0005737; GO:0005730; GO:0009303 DNA binding; DNA-directed RNA polymerase activity; cell junction; cytoplasm; nucleolus; rRNA transcription IPR009668; DNA-directed RNA polymerase I subunit RPA49 (RNA polymerase I subunit A49) (DNA-directed RNA polymerase I subunit E) (RNA polymerase I-associated factor 1) (RNA polymerase I-associated factor 53) POLR1E PAF53 PRAF1 Homo sapiens (Human) TR36467_c0_g2_i2 Q8N0N9 ODH_HALDH 4.00E-147 GO:0051287; GO:0005737; GO:0046168; GO:0016616 "NAD binding; cytoplasm; glycerol-3-phosphate catabolic process; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" IPR008927; IPR013328; IPR011128; IPR016040; IPR003421; Opine dehydrogenase (EC 1.5.1.-) tadh Haliotis discus hannai (Japanese abalone) TR36467_c0_g2_i3 Q9BHM6 OCDH_PECMA 2.00E-134 GO:0047830; GO:0051287; GO:0005737; GO:0046168; GO:0016616 "D-octopine dehydrogenase activity; NAD binding; cytoplasm; glycerol-3-phosphate catabolic process; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" IPR008927; IPR013328; IPR011128; IPR016040; IPR003421; Octopine dehydrogenase (OcDH) (EC 1.5.1.11) odh1 Pecten maximus (King scallop) (Pilgrim's clam) TR36467_c0_g2_i4 Q44297 ODH_ARTSC 8.00E-19 GO:0051287; GO:0005737; GO:0046168; GO:0047129; GO:0016616 "NAD binding; cytoplasm; glycerol-3-phosphate catabolic process; opine dehydrogenase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" IPR008927; IPR013328; IPR011128; IPR016040; IPR003421; Opine dehydrogenase (EC 1.5.1.28) (N-(1-D-carboxyethyl)-L-norvaline dehydrogenase) odh Arthrobacter sp. (strain 1C) TR36469_c0_g1_i1 Q9NWT6 HIF1N_HUMAN 6.00E-131 GO:0031406; GO:0048037; GO:0005829; GO:0005506; GO:0045746; GO:0061428; GO:0005634; GO:0019826; GO:0036140; GO:0042265; GO:0042264; GO:0036139; GO:0036138; GO:0048471; GO:0045663; GO:2001214; GO:0042803; GO:0006351; GO:0008270 Q96DX5; Q16665; O95271; Q9H2K2 "carboxylic acid binding; cofactor binding; cytosol; iron ion binding; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia; nucleus; oxygen sensor activity; peptidyl-asparagine 3-dioxygenase activity; peptidyl-asparagine hydroxylation; peptidyl-aspartic acid hydroxylation; peptidyl-histidine dioxygenase activity; peptidyl-histidine hydroxylation; perinuclear region of cytoplasm; positive regulation of myoblast differentiation; positive regulation of vasculogenesis; protein homodimerization activity; transcription, DNA-dependent; zinc ion binding" IPR027452; IPR003347; Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30) (EC 1.14.11.n4) (Factor inhibiting HIF-1) (FIH-1) (Hypoxia-inducible factor asparagine hydroxylase) HIF1AN FIH1 Homo sapiens (Human) TR36470_c1_g1_i1 Q5ZIF1 APMAP_CHICK 2.00E-86 GO:0004064; GO:0009058; GO:0009986; GO:0016021; GO:0016844 arylesterase activity; biosynthetic process; cell surface; integral to membrane; strictosidine synthase activity IPR011042; IPR018119; Adipocyte plasma membrane-associated protein APMAP RCJMB04_27f14 Gallus gallus (Chicken) TR36473_c1_g1_i1 Q69Z28 ATS16_MOUSE 4.00E-27 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16) (EC 3.4.24.-) Adamts16 Kiaa2029 Mus musculus (Mouse) TR36473_c1_g1_i3 Q8TE60 ATS18_HUMAN 7.00E-27 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAM-TS 18) (ADAM-TS18) (ADAMTS-18) (EC 3.4.24.-) ADAMTS18 ADAMTS21 Homo sapiens (Human) TR36474_c2_g2_i1 P97281 SGCD_MESAU 3.00E-17 GO:0005737; GO:0005856; GO:0016021; GO:0016012; GO:0042383 cytoplasm; cytoskeleton; integral to membrane; sarcoglycan complex; sarcolemma IPR006875; IPR027661; Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG) SGCD Mesocricetus auratus (Golden hamster) TR36475_c0_g1_i1 P53621 COPA_HUMAN 0 GO:0048205; GO:0030126; GO:0005829; GO:0005615; GO:0006886; GO:0030157; GO:0006890; GO:0005198 "COPI coating of Golgi vesicle; COPI vesicle coat; cytosol; extracellular space; intracellular protein transport; pancreatic juice secretion; retrograde vesicle-mediated transport, Golgi to ER; structural molecule activity" IPR016391; IPR010714; IPR006692; IPR020472; IPR011048; IPR015943; IPR001680; IPR019775; IPR017986; Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] COPA Homo sapiens (Human) TR36475_c0_g1_i2 Q5R664 COPB2_PONAB 4.00E-72 GO:0030663; GO:0006886; GO:0030117; GO:0005198; GO:0016192 COPI-coated vesicle membrane; intracellular protein transport; membrane coat; structural molecule activity; vesicle-mediated transport IPR006692; IPR016453; IPR020472; IPR015943; IPR001680; IPR017986; Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) COPB2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36476_c1_g2_i1 O60293 ZC3H1_HUMAN 2.00E-63 GO:0006396; GO:0005622; GO:0046872 P10242 RNA processing; intracellular; metal ion binding IPR003107; IPR019607; IPR013026; Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) ZFC3H1 CCDC131 KIAA0546 PSRC2 Homo sapiens (Human) TR36476_c1_g2_i4 Q6CJK2 CLF1_KLULA 8.00E-08 GO:0008380; GO:0007049; GO:0006397; GO:0005681 RNA splicing; cell cycle; mRNA processing; spliceosomal complex IPR003107; IPR011990; Pre-mRNA-splicing factor CLF1 CLF1 KLLA0F17996g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR36477_c0_g1_i1 Q8BZ39 NMUR2_MOUSE 2.00E-55 GO:0005525; GO:0043006; GO:0050482; GO:0006816; GO:0007417; GO:0007204; GO:0007625; GO:0048016; GO:0016021; GO:0005229; GO:0042924; GO:0001607; GO:0008188; GO:0007200; GO:0005886; GO:0002023; GO:0048265 GTP binding; activation of phospholipase A2 activity by calcium-mediated signaling; arachidonic acid secretion; calcium ion transport; central nervous system development; elevation of cytosolic calcium ion concentration; grooming behavior; inositol phosphate-mediated signaling; integral to membrane; intracellular calcium activated chloride channel activity; neuromedin U binding; neuromedin U receptor activity; neuropeptide receptor activity; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; reduction of food intake in response to dietary excess; response to pain IPR000276; IPR017452; IPR005390; IPR005392; Neuromedin-U receptor 2 (NMU-R2) Nmur2 Mus musculus (Mouse) TR36477_c0_g1_i3 Q8BZ39 NMUR2_MOUSE 7.00E-45 GO:0005525; GO:0043006; GO:0050482; GO:0006816; GO:0007417; GO:0007204; GO:0007625; GO:0048016; GO:0016021; GO:0005229; GO:0042924; GO:0001607; GO:0008188; GO:0007200; GO:0005886; GO:0002023; GO:0048265 GTP binding; activation of phospholipase A2 activity by calcium-mediated signaling; arachidonic acid secretion; calcium ion transport; central nervous system development; elevation of cytosolic calcium ion concentration; grooming behavior; inositol phosphate-mediated signaling; integral to membrane; intracellular calcium activated chloride channel activity; neuromedin U binding; neuromedin U receptor activity; neuropeptide receptor activity; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; reduction of food intake in response to dietary excess; response to pain IPR000276; IPR017452; IPR005390; IPR005392; Neuromedin-U receptor 2 (NMU-R2) Nmur2 Mus musculus (Mouse) TR36479_c2_g1_i1 P18042 POL_HV2G1 1.00E-06 GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0075713; GO:0004533; GO:0030430; GO:0042025; GO:0020002; GO:0016020; GO:0090305; GO:0006508; GO:0004523; GO:0005198; GO:0039604; GO:0046718; GO:0019013; GO:0075732; GO:0046797; GO:0008270 DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; establishment of integrated proviral latency; exoribonuclease H activity; host cell cytoplasm; host cell nucleus; host cell plasma membrane; membrane; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; structural molecule activity; suppression by virus of host translation; viral entry into host cell; viral nucleocapsid; viral penetration into host nucleus; viral procapsid maturation; zinc ion binding IPR001969; IPR000721; IPR001037; IPR001584; IPR017856; IPR003308; IPR000071; IPR012344; IPR018061; IPR001995; IPR021109; IPR008916; IPR008919; IPR010999; IPR012337; IPR002156; IPR000477; IPR010659; IPR010661; IPR001878; Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide p2; Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.47) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN)] gag-pol Human immunodeficiency virus type 2 subtype A (isolate Ghana-1) (HIV-2) TR36479_c4_g1_i1 Q9D3W4 GPN3_MOUSE 7.00E-113 GO:0005525 GTP binding IPR027417; IPR004130; GPN-loop GTPase 3 (ATP-binding domain 1 family member C) Gpn3 Atpbd1c D5Ertd708e Mus musculus (Mouse) TR36479_c5_g1_i1 A7Y2W8 SC6A9_XENLA 0 GO:0005887; GO:0005328; GO:0005283 integral to plasma membrane; neurotransmitter:sodium symporter activity; sodium:amino acid symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9) slc6a9 glyt1 Xenopus laevis (African clawed frog) TR36479_c5_g1_i3 O18875 SC6A8_BOVIN 5.00E-135 GO:0005309; GO:0005887; GO:0005328 creatine:sodium symporter activity; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR002984; Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8) SLC6A8 Bos taurus (Bovine) TR36479_c6_g1_i2 O50655 XERD_SELRU 6.00E-14 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR36480_c0_g1_i1 P41247 PLPL4_HUMAN 8.00E-67 GO:0016042; GO:0004806 lipid catabolic process; triglyceride lipase activity IPR016035; IPR002641; Patatin-like phospholipase domain-containing protein 4 (EC 3.1.1.3) (Protein GS2) PNPLA4 DXS1283E GS2 Homo sapiens (Human) TR36480_c1_g1_i1 Q2TBP4 POC1A_BOVIN 0 GO:0030030; GO:0005814; GO:0005932 cell projection organization; centriole; microtubule basal body IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; POC1 centriolar protein homolog A (WD repeat-containing protein 51A) POC1A WDR51A Bos taurus (Bovine) TR36482_c2_g1_i2 Q6GM16 NXN_XENLA 5.00E-82 GO:0016055; GO:0072358; GO:0030154; GO:0005829; GO:0030178; GO:0031397; GO:0005634; GO:0047134 Wnt receptor signaling pathway; cardiovascular system development; cell differentiation; cytosol; negative regulation of Wnt receptor signaling pathway; negative regulation of protein ubiquitination; nucleus; protein-disulfide reductase activity IPR012336; Nucleoredoxin (EC 1.8.1.8) nxn Xenopus laevis (African clawed frog) TR36483_c1_g2_i1 Q617Y0 MIG23_CAEBR 6.00E-21 GO:0000139; GO:0030154; GO:0007506; GO:0016021; GO:0045134 Golgi membrane; cell differentiation; gonadal mesoderm development; integral to membrane; uridine-diphosphatase activity IPR000407; Nucleoside-diphosphatase mig-23 (NDPase) (EC 3.6.1.6) (Abnormal cell migration protein 23) mig-23 CBG14784 Caenorhabditis briggsae TR36483_c1_g2_i2 Q9MYU4 ENTP1_PIG 4.00E-49 GO:0005524; GO:0005975; GO:0016787; GO:0016021; GO:0016616 "ATP binding; carbohydrate metabolic process; hydrolase activity; integral to membrane; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" IPR000407; IPR015955; Ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) (EC 3.6.1.5) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (CD antigen CD39) [Cleaved into: Ectonucleoside triphosphate diphosphohydrolase 1 27 kDa subunit; Ectonucleoside triphosphate diphosphohydrolase 1 54 kDa subunit] ENTPD1 CD39 Sus scrofa (Pig) TR36486_c1_g4_i1 Q80UP3 DGKZ_MOUSE 0 GO:0005524; GO:0003951; GO:0005737; GO:0004143; GO:0004857; GO:0035556; GO:0046872; GO:0046580; GO:0005634; GO:0005886; GO:0007205 P13405 ATP binding; NAD+ kinase activity; cytoplasm; diacylglycerol kinase activity; enzyme inhibitor activity; intracellular signal transduction; metal ion binding; negative regulation of Ras protein signal transduction; nucleus; plasma membrane; protein kinase C-activating G-protein coupled receptor signaling pathway IPR002110; IPR020683; IPR016064; IPR000756; IPR001206; IPR002219; Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) Dgkz Mus musculus (Mouse) TR36486_c1_g4_i2 Q13574 DGKZ_HUMAN 2.00E-18 GO:0005524; GO:0003951; GO:0016477; GO:0005737; GO:0004143; GO:0004857; GO:0035556; GO:0030027; GO:0001727; GO:0046872; GO:0031571; GO:0046580; GO:0045930; GO:0005634; GO:0005886; GO:0030168; GO:0008022; GO:0007205 P06400; P28749; Q08999 ATP binding; NAD+ kinase activity; cell migration; cytoplasm; diacylglycerol kinase activity; enzyme inhibitor activity; intracellular signal transduction; lamellipodium; lipid kinase activity; metal ion binding; mitotic G1 DNA damage checkpoint; negative regulation of Ras protein signal transduction; negative regulation of mitotic cell cycle; nucleus; plasma membrane; platelet activation; protein C-terminus binding; protein kinase C-activating G-protein coupled receptor signaling pathway IPR002110; IPR020683; IPR016064; IPR000756; IPR001206; IPR002219; Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) DGKZ DAGK6 Homo sapiens (Human) TR36487_c0_g1_i1 Q5ZJF4 PRDX6_CHICK 8.00E-104 GO:0016023; GO:0016787; GO:0016042; GO:0005764; GO:0004601; GO:0051920 cytoplasmic membrane-bounded vesicle; hydrolase activity; lipid catabolic process; lysosome; peroxidase activity; peroxiredoxin activity IPR000866; IPR024706; IPR019479; IPR012336; Peroxiredoxin-6 (EC 1.11.1.15) PRDX6 RCJMB04_18k11 Gallus gallus (Chicken) TR36487_c0_g1_i3 P86215 PRDX6_MESAU 5.00E-11 GO:0005737; GO:0016023; GO:0004602; GO:0016787; GO:0016042; GO:0005764; GO:0051920 cytoplasm; cytoplasmic membrane-bounded vesicle; glutathione peroxidase activity; hydrolase activity; lipid catabolic process; lysosome; peroxiredoxin activity IPR012336; Peroxiredoxin-6 (EC 1.11.1.15) (1-Cys peroxiredoxin) (1-Cys PRX) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.-) (Antioxidant protein 2) (Non-selenium glutathione peroxidase) (NSGPx) (EC 1.11.1.9) (Fragments) PRDX6 Mesocricetus auratus (Golden hamster) TR36487_c0_g1_i4 P52572 REHY_HORVU 1.00E-71 GO:0005634; GO:0004601; GO:0051920 nucleus; peroxidase activity; peroxiredoxin activity IPR000866; IPR024706; IPR019479; IPR012336; 1-Cys peroxiredoxin PER1 (EC 1.11.1.15) (B15C) (Rehydrin homolog) (Thioredoxin peroxidase) PER1 Hordeum vulgare (Barley) TR36487_c0_g1_i5 O77834 PRDX6_BOVIN 3.00E-101 GO:0016023; GO:0005829; GO:0004602; GO:0005764; GO:0004601; GO:0051920; GO:0004623; GO:0009395; GO:0000302 cytoplasmic membrane-bounded vesicle; cytosol; glutathione peroxidase activity; lysosome; peroxidase activity; peroxiredoxin activity; phospholipase A2 activity; phospholipid catabolic process; response to reactive oxygen species IPR000866; IPR024706; IPR019479; IPR012336; Peroxiredoxin-6 (EC 1.11.1.15) (1-Cys peroxiredoxin) (1-Cys PRX) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.-) (Antioxidant protein 2) (Ciliary body glutathione peroxidase) (Non-selenium glutathione peroxidase) (NSGPx) (EC 1.11.1.9) (PHGPx) PRDX6 AOP2 GPX PHGPX Bos taurus (Bovine) TR36488_c0_g1_i1 Q460N5 PAR14_HUMAN 1.00E-69 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR36489_c1_g1_i2 Q9V4A7 PLXB_DROME 2.00E-42 GO:0016021; GO:0005622; GO:0008045; GO:0035021; GO:0005886; GO:0035025; GO:0004872; GO:0007165 integral to membrane; intracellular; motor neuron axon guidance; negative regulation of Rac protein signal transduction; plasma membrane; positive regulation of Rho protein signal transduction; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-B plexB CG17245 Drosophila melanogaster (Fruit fly) TR36489_c1_g1_i5 O45657 PLX2_CAEEL 3.00E-20 GO:0030154; GO:0031252; GO:0009986; GO:0009792; GO:0016021; GO:0005622; GO:0002119; GO:0005886; GO:0004872; GO:0007165; GO:0045138 cell differentiation; cell leading edge; cell surface; embryo development ending in birth or egg hatching; integral to membrane; intracellular; nematode larval development; plasma membrane; receptor activity; signal transduction; tail tip morphogenesis IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-2 plx-2 K04B12.1 Caenorhabditis elegans TR36489_c1_g1_i6 Q9V4A7 PLXB_DROME 4.00E-60 GO:0016021; GO:0005622; GO:0008045; GO:0035021; GO:0005886; GO:0035025; GO:0004872; GO:0007165 integral to membrane; intracellular; motor neuron axon guidance; negative regulation of Rac protein signal transduction; plasma membrane; positive regulation of Rho protein signal transduction; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-B plexB CG17245 Drosophila melanogaster (Fruit fly) TR36489_c1_g1_i8 Q9ULL4 PLXB3_HUMAN 3.00E-33 GO:0007411; GO:0016021; GO:0005622; GO:0005886; GO:0004872; GO:0007165 Q16658; P08581; Q04912 axon guidance; integral to membrane; intracellular; plasma membrane; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-B3 PLXNB3 KIAA1206 PLXN6 Homo sapiens (Human) TR36490_c0_g1_i1 Q76PC3 YQ73_SCHPO 3.00E-18 GO:0016021; GO:0005743; GO:0006839; GO:0022857 integral to membrane; mitochondrial inner membrane; mitochondrial transport; transmembrane transporter activity IPR018108; IPR023395; Uncharacterized mitochondrial carrier C1442.03 SPCC1442.03 SPCC1450.19 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36490_c0_g1_i2 Q6P316 S2540_XENTR 1.00E-115 GO:0016021; GO:0005743; GO:0055085 integral to membrane; mitochondrial inner membrane; transmembrane transport IPR002067; IPR018108; IPR023395; Solute carrier family 25 member 40 slc25a40 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36492_c1_g1_i1 Q05187 TGMH_TACTR 1.00E-173 GO:0016020; GO:0046872; GO:0018149; GO:0003810 membrane; metal ion binding; peptide cross-linking; protein-glutamine gamma-glutamyltransferase activity IPR023608; IPR013783; IPR014756; IPR002931; IPR008958; IPR013808; IPR001102; Hemocyte protein-glutamine gamma-glutamyltransferase (EC 2.3.2.13) (Hemocyte transglutaminase) (TGase) Tachypleus tridentatus (Japanese horseshoe crab) TR36495_c2_g1_i1 Q5T4S7 UBR4_HUMAN 0 GO:0005737; GO:0005856; GO:0016021; GO:0019048; GO:0005634; GO:0042787; GO:0004842; GO:0008270 P03129 cytoplasm; cytoskeleton; integral to membrane; modulation by virus of host morphology or physiology; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR016024; IPR025704; IPR017986; IPR003126; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UBR4 (EC 6.3.2.-) (600 kDa retinoblastoma protein-associated factor) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) (p600) (Zinc finger UBR1-type protein 1) UBR4 KIAA0462 KIAA1307 RBAF600 ZUBR1 Homo sapiens (Human) TR36495_c2_g4_i1 Q5T4S7 UBR4_HUMAN 7.00E-104 GO:0005737; GO:0005856; GO:0016021; GO:0019048; GO:0005634; GO:0042787; GO:0004842; GO:0008270 P03129 cytoplasm; cytoskeleton; integral to membrane; modulation by virus of host morphology or physiology; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR016024; IPR025704; IPR017986; IPR003126; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UBR4 (EC 6.3.2.-) (600 kDa retinoblastoma protein-associated factor) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) (p600) (Zinc finger UBR1-type protein 1) UBR4 KIAA0462 KIAA1307 RBAF600 ZUBR1 Homo sapiens (Human) TR36496_c0_g1_i1 Q728P4 BIOA_DESVH 2.00E-19 GO:0004015; GO:0009102; GO:0005737; GO:0030170 adenosylmethionine-8-amino-7-oxononanoate transaminase activity; biotin biosynthetic process; cytoplasm; pyridoxal phosphate binding IPR005814; IPR005815; IPR015424; IPR015421; IPR015422; "Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1." "Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) (7,8-diamino-pelargonic acid aminotransferase) (DAPA AT) (DAPA aminotransferase) (7,8-diaminononanoate synthase) (DANS) (Diaminopelargonic acid synthase)" bioA DVU_2559 Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) TR36496_c0_g1_i2 P80147 GABT_PIG 0 GO:0047298; GO:0003867; GO:0032144; GO:0048148; GO:0005829; GO:0009450; GO:0005759; GO:0042135; GO:0042803; GO:0030170; GO:0032145 (S)-3-amino-2-methylpropionate transaminase activity; 4-aminobutyrate transaminase activity; 4-aminobutyrate transaminase complex; behavioral response to cocaine; cytosol; gamma-aminobutyric acid catabolic process; mitochondrial matrix; neurotransmitter catabolic process; protein homodimerization activity; pyridoxal phosphate binding; succinate-semialdehyde dehydrogenase binding IPR004631; IPR005814; IPR015424; IPR015421; IPR015422; "4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT)" ABAT GABAT Sus scrofa (Pig) TR36496_c0_g1_i3 Q7W979 ECTB_BORPA 4.00E-10 GO:0045303; GO:0047307; GO:0019491; GO:0030170 diaminobutyrate-2-oxoglutarate transaminase activity; diaminobutyrate-pyruvate transaminase activity; ectoine biosynthetic process; pyridoxal phosphate binding IPR005814; IPR004637; IPR012773; IPR015424; IPR015421; IPR015422; Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 1/3. "Diaminobutyrate--2-oxoglutarate transaminase (EC 2.6.1.76) (DABA aminotransferase) (Diaminobutyrate--2-oxoglutarate aminotransferase) (L-2,4-diaminobutyric acid transaminase)" ectB BPP1889 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) TR36496_c0_g1_i4 Q7VAS9 ARGD_PROMA 2.00E-32 GO:0003992; GO:0006526; GO:0005737; GO:0030170 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity; arginine biosynthetic process; cytoplasm; pyridoxal phosphate binding IPR005814; IPR015424; IPR015421; IPR015422; IPR004636; Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4. Acetylornithine aminotransferase (ACOAT) (EC 2.6.1.11) argD Pro_1375 Prochlorococcus marinus (strain SARG / CCMP1375 / SS120) TR36496_c0_g1_i5 P80147 GABT_PIG 4.00E-161 GO:0047298; GO:0003867; GO:0032144; GO:0048148; GO:0005829; GO:0009450; GO:0005759; GO:0042135; GO:0042803; GO:0030170; GO:0032145 (S)-3-amino-2-methylpropionate transaminase activity; 4-aminobutyrate transaminase activity; 4-aminobutyrate transaminase complex; behavioral response to cocaine; cytosol; gamma-aminobutyric acid catabolic process; mitochondrial matrix; neurotransmitter catabolic process; protein homodimerization activity; pyridoxal phosphate binding; succinate-semialdehyde dehydrogenase binding IPR004631; IPR005814; IPR015424; IPR015421; IPR015422; "4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT)" ABAT GABAT Sus scrofa (Pig) TR36496_c0_g1_i6 Q7VAS9 ARGD_PROMA 8.00E-30 GO:0003992; GO:0006526; GO:0005737; GO:0030170 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity; arginine biosynthetic process; cytoplasm; pyridoxal phosphate binding IPR005814; IPR015424; IPR015421; IPR015422; IPR004636; Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4. Acetylornithine aminotransferase (ACOAT) (EC 2.6.1.11) argD Pro_1375 Prochlorococcus marinus (strain SARG / CCMP1375 / SS120) TR36497_c0_g1_i1 Q9D411 TSSK4_MOUSE 6.00E-29 GO:0005524; GO:0001669; GO:0030154; GO:0000287; GO:0031514; GO:0007275; GO:0032793; GO:0004674; GO:0007283 ATP binding; acrosomal vesicle; cell differentiation; magnesium ion binding; motile cilium; multicellular organismal development; positive regulation of CREB transcription factor activity; protein serine/threonine kinase activity; spermatogenesis IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Testis-specific serine/threonine-protein kinase 4 (TSK-4) (TSSK-4) (Testis-specific kinase 4) (EC 2.7.11.1) Tssk4 Mus musculus (Mouse) TR36497_c0_g1_i2 Q6H7U5 CIPKQ_ORYSJ 5.00E-27 GO:0005524; GO:0004674; GO:0007165 ATP binding; protein serine/threonine kinase activity; signal transduction IPR020636; IPR011009; IPR018451; IPR004041; IPR000719; IPR017441; IPR002290; IPR008271; CBL-interacting protein kinase 26 (EC 2.7.11.1) (OsCIPK26) CIPK26 Os02g0161000 LOC_Os02g06570 B1103G11.47 OJ9003_G05.12 OsJ_005311 Oryza sativa subsp. japonica (Rice) TR36497_c0_g1_i3 Q02723 RKIN1_SECCE 1.00E-21 GO:0005524; GO:0005975; GO:0004674 ATP binding; carbohydrate metabolic process; protein serine/threonine kinase activity IPR028375; IPR001772; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR015940; Carbon catabolite-derepressing protein kinase (EC 2.7.11.1) RKIN1 Secale cereale (Rye) TR36497_c0_g1_i4 Q8C0N0 SMKZ_MOUSE 1.00E-22 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR002290; IPR008271; Sperm motility kinase Z (EC 2.7.11.1) Gm4922 Mus musculus (Mouse) TR36499_c1_g1_i1 Q68EJ0 NB5R4_RAT 7.00E-107 GO:0006739; GO:0003958; GO:0004128; GO:0005783; GO:0050660; GO:0020037; GO:0046872 "NADP metabolic process; NADPH-hemoprotein reductase activity; cytochrome-b5 reductase activity, acting on NAD(P)H; endoplasmic reticulum; flavin adenine dinucleotide binding; heme binding; metal ion binding" IPR007052; IPR001199; IPR018506; IPR017927; IPR008978; IPR001834; IPR008333; IPR001433; IPR017938; Cytochrome b5 reductase 4 (EC 1.6.2.2) (Flavohemoprotein b5/b5R) (b5+b5R) (N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein) (cb5/cb5R) Cyb5r4 Ncb5or Rattus norvegicus (Rat) TR36499_c1_g1_i2 Q10352 YDAA_SCHPO 6.00E-23 GO:0003958; GO:0005829; GO:0020037; GO:0042168; GO:0046872; GO:0005634 NADPH-hemoprotein reductase activity; cytosol; heme binding; heme metabolic process; metal ion binding; nucleus IPR001199; IPR018506; Uncharacterized protein C1F12.10c SPAC1F12.10c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36499_c1_g1_i3 Q12746 PGA3_YEAST 1.00E-28 GO:0001300; GO:0004128; GO:0005789; GO:0016021; GO:0005886; GO:0015031; GO:0001302 "chronological cell aging; cytochrome-b5 reductase activity, acting on NAD(P)H; endoplasmic reticulum membrane; integral to membrane; plasma membrane; protein transport; replicative cell aging" IPR017927; IPR001709; IPR001834; IPR008333; IPR001433; IPR017938; Plasma membrane-associated coenzyme Q6 reductase PGA3 (EC 1.6.-.-) (Processing of GAS1 and ALP protein 3) PGA3 NQR1 YML125C YM4987.10C YM7056.01C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR36499_c1_g1_i4 Q68EJ0 NB5R4_RAT 1.00E-106 GO:0006739; GO:0003958; GO:0004128; GO:0005783; GO:0050660; GO:0020037; GO:0046872 "NADP metabolic process; NADPH-hemoprotein reductase activity; cytochrome-b5 reductase activity, acting on NAD(P)H; endoplasmic reticulum; flavin adenine dinucleotide binding; heme binding; metal ion binding" IPR007052; IPR001199; IPR018506; IPR017927; IPR008978; IPR001834; IPR008333; IPR001433; IPR017938; Cytochrome b5 reductase 4 (EC 1.6.2.2) (Flavohemoprotein b5/b5R) (b5+b5R) (N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein) (cb5/cb5R) Cyb5r4 Ncb5or Rattus norvegicus (Rat) TR36500_c1_g2_i1 Q66II5 T3HPD_XENTR 3.00E-135 GO:0016836; GO:0050346 hydro-lyase activity; trans-L-3-hydroxyproline dehydratase activity IPR008794; Trans-L-3-hydroxyproline dehydratase (EC 4.2.1.77) (Trans-3-hydroxy-l-proline dehydratase) l3hypdh Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36503_c1_g2_i4 P22031 LEG_ANTCR 2.00E-12 GO:0030246; GO:0005737 carbohydrate binding; cytoplasm IPR000922; D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL) Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR36503_c1_g2_i6 P86179 CSL3_ONCKE 2.00E-10 GO:0030246 carbohydrate binding IPR000922; L-rhamnose-binding lectin CSL3 Oncorhynchus keta (Chum salmon) (Salmo keta) TR36505_c0_g2_i1 Q01484 ANK2_HUMAN 2.00E-28 GO:0051117; GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0007411; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005829; GO:0005887; GO:0014704; GO:0044325; GO:0086046; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307; GO:0070296 P11532-5; P62993 "ATPase binding; M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; axon guidance; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; cytosol; integral to plasma membrane; intercalated disc; ion channel binding; membrane depolarization involved in regulation of SA node cell action potential; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization; sarcoplasmic reticulum calcium ion transport" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) TR36506_c4_g1_i1 O35678 MGLL_MOUSE 6.00E-49 GO:0046464; GO:0047372; GO:0019369; GO:0004091; GO:0006633; GO:0060292; GO:2000124; GO:0050727; GO:0051930; GO:0019433 acylglycerol catabolic process; acylglycerol lipase activity; arachidonic acid metabolic process; carboxylesterase activity; fatty acid biosynthetic process; long term synaptic depression; regulation of endocannabinoid signaling pathway; regulation of inflammatory response; regulation of sensory perception of pain; triglyceride catabolic process IPR000073; IPR022742; Glycerolipid metabolism; triacylglycerol degradation. Monoglyceride lipase (MGL) (EC 3.1.1.23) (Monoacylglycerol lipase) (MAGL) Mgll Mus musculus (Mouse) TR36507_c0_g1_i1 A8E5W8 F166B_XENTR 3.00E-68 IPR018902; Protein FAM166B fam166b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36509_c0_g2_i2 Q9BV73 CP250_HUMAN 1.00E-31 GO:0000086; GO:0005814; GO:0010457; GO:0005929; GO:0005829; GO:0005932; GO:0048471; GO:0043234; GO:0008104; GO:0030997; GO:0031616 O88566; Q9H0K1 G2/M transition of mitotic cell cycle; centriole; centriole-centriole cohesion; cilium; cytosol; microtubule basal body; perinuclear region of cytoplasm; protein complex; protein localization; regulation of centriole-centriole cohesion; spindle pole centrosome IPR026048; Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) CEP250 CEP2 CNAP1 Homo sapiens (Human) TR36509_c0_g2_i5 Q5TZA2 CROCC_HUMAN 4.00E-78 GO:0015629; GO:0007049; GO:0030030; GO:0005814; GO:0051297; GO:0035253; GO:0019894; GO:0005886; GO:0008104; GO:0005198 actin cytoskeleton; cell cycle; cell projection organization; centriole; centrosome organization; ciliary rootlet; kinesin binding; plasma membrane; protein localization; structural molecule activity IPR026733; Rootletin (Ciliary rootlet coiled-coil protein) CROCC KIAA0445 Homo sapiens (Human) TR36509_c1_g4_i1 Q8CJ40 CROCC_MOUSE 3.00E-131 GO:0015629; GO:0007049; GO:0030030; GO:0005814; GO:0051297; GO:0035253; GO:0005886; GO:0008104; GO:0005198 actin cytoskeleton; cell cycle; cell projection organization; centriole; centrosome organization; ciliary rootlet; plasma membrane; protein localization; structural molecule activity IPR026733; Rootletin (Ciliary rootlet coiled-coil protein) Crocc Kiaa0445 Mus musculus (Mouse) TR36512_c2_g1_i2 Q9RUW8 RO60_DEIRA 9.00E-30 GO:0003723; GO:0005737; GO:0046872; GO:0030529 RNA binding; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein homolog (Ro sixty-related protein) rsr DR_1262 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) TR36512_c2_g1_i5 Q27274 RO60_CAEEL 4.00E-39 GO:0003723; GO:0005737; GO:0046872; GO:0030529 RNA binding; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein homolog rop-1 C12D8.11 Caenorhabditis elegans TR36512_c2_g3_i1 P42700 RO60_XENLA 4.00E-47 GO:0003723; GO:0030030; GO:0005737; GO:0046872; GO:0030529 RNA binding; cell projection organization; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) trove2 Xenopus laevis (African clawed frog) TR36512_c2_g4_i2 P42700 RO60_XENLA 6.00E-77 GO:0003723; GO:0030030; GO:0005737; GO:0046872; GO:0030529 RNA binding; cell projection organization; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) trove2 Xenopus laevis (African clawed frog) TR36512_c2_g4_i3 Q27274 RO60_CAEEL 2.00E-35 GO:0003723; GO:0005737; GO:0046872; GO:0030529 RNA binding; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein homolog rop-1 C12D8.11 Caenorhabditis elegans TR36513_c7_g1_i1 Q8NHV1 GIMA7_HUMAN 9.00E-30 GO:0005525; GO:0003924; GO:0005811 GTP binding; GTPase activity; lipid particle IPR006703; IPR027417; GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) TR36517_c0_g1_i1 Q5UPF8 YL088_MIMIV 3.00E-14 IPR002110; IPR020683; Putative ankyrin repeat protein L88 MIMI_L88 Acanthamoeba polyphaga mimivirus (APMV) TR36517_c0_g1_i3 Q9C0D5 TANC1_HUMAN 4.00E-12 GO:0043679; GO:0030054; GO:0030425; GO:0097062; GO:0007520; GO:0043025; GO:0014069; GO:0045211; GO:0008542 axon terminus; cell junction; dendrite; dendritic spine maintenance; myoblast fusion; neuronal cell body; postsynaptic density; postsynaptic membrane; visual learning IPR002110; IPR020683; IPR027417; IPR013026; IPR011990; IPR013105; IPR019734; "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" TANC1 KIAA1728 Homo sapiens (Human) TR36519_c0_g2_i1 A8KBF3 PIWL2_XENTR 2.00E-176 GO:0043046; GO:0000966; GO:0031047; GO:0030718; GO:0007126; GO:0007275; GO:0005634; GO:0071546; GO:0034584; GO:0034587; GO:0006417 Q98SP8; Q7ZYV9; Q90WE3 DNA methylation involved in gamete generation; RNA 5'-end processing; gene silencing by RNA; germ-line stem cell maintenance; meiosis; multicellular organismal development; nucleus; pi-body; piRNA binding; piRNA metabolic process; regulation of translation IPR003100; IPR003165; IPR012337; Piwi-like protein 2 piwil2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR3652_c0_g1_i1 P08582 TRFM_HUMAN 3.00E-23 GO:0031225; GO:0006879; GO:0005576; GO:0008199; GO:0005887; GO:0005506; GO:0006826 anchored to membrane; cellular iron ion homeostasis; extracellular region; ferric iron binding; integral to plasma membrane; iron ion binding; iron ion transport IPR016357; IPR001156; IPR018195; Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228) MFI2 MAP97 Homo sapiens (Human) TR36520_c0_g1_i4 Q9USW6 DPM2_SCHPO 4.00E-09 GO:0006506; GO:0005783; GO:0030176; GO:0006487; GO:0006493 GPI anchor biosynthetic process; endoplasmic reticulum; integral to endoplasmic reticulum membrane; protein N-linked glycosylation; protein O-linked glycosylation IPR009914; Dolichol phosphate-mannose biosynthesis regulatory protein dpm2 SPBC21B10.11 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36520_c0_g1_i8 Q9USW6 DPM2_SCHPO 4.00E-09 GO:0006506; GO:0005783; GO:0030176; GO:0006487; GO:0006493 GPI anchor biosynthetic process; endoplasmic reticulum; integral to endoplasmic reticulum membrane; protein N-linked glycosylation; protein O-linked glycosylation IPR009914; Dolichol phosphate-mannose biosynthesis regulatory protein dpm2 SPBC21B10.11 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36521_c0_g1_i3 Q63525 NUDC_RAT 2.00E-12 GO:0005794; GO:0051301; GO:0005874; GO:0007067; GO:0007097; GO:0005634; GO:0043434 Golgi apparatus; cell division; microtubule; mitosis; nuclear migration; nucleus; response to peptide hormone stimulus IPR007052; IPR008978; IPR025934; Nuclear migration protein nudC (Nuclear distribution protein C homolog) (c15) Nudc Rattus norvegicus (Rat) TR36521_c0_g1_i6 Q8IVD9 NUDC3_HUMAN 3.00E-44 IPR007052; IPR008978; IPR025934; IPR027761; NudC domain-containing protein 3 NUDCD3 KIAA1068 Homo sapiens (Human) TR36521_c0_g3_i2 P17624 NUDC_EMENI 9.00E-13 GO:0051301; GO:0005737; GO:0031505; GO:0000741; GO:0005874; GO:0007067; GO:0030473 cell division; cytoplasm; fungal-type cell wall organization; karyogamy; microtubule; mitosis; nuclear migration along microtubule IPR007052; IPR008978; Nuclear movement protein nudC (Nuclear distribution protein C) nudC AN5181 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR36522_c2_g1_i1 Q9VYA0 NADE_DROME 3.00E-32 GO:0005524; GO:0009435; GO:0003952; GO:0016810 "ATP binding; NAD biosynthetic process; NAD+ synthase (glutamine-hydrolyzing) activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds" IPR003010; IPR014445; IPR022310; IPR003694; IPR014729; Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1. Probable glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) CG9940 Drosophila melanogaster (Fruit fly) TR36523_c0_g3_i1 Q80U30 CL16A_MOUSE 0 IPR019155; Protein CLEC16A Clec16a Kiaa0350 Mus musculus (Mouse) TR36523_c0_g3_i3 Q80U30 CL16A_MOUSE 0 IPR019155; Protein CLEC16A Clec16a Kiaa0350 Mus musculus (Mouse) TR36526_c5_g1_i1 Q27802 DYHC2_TRIGR 5.00E-145 GO:0005524; GO:0006200; GO:0016887; GO:0030031; GO:0001539; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018; GO:0007275; GO:0005886 ATP binding; ATP catabolic process; ATPase activity; cell projection assembly; ciliary or bacterial-type flagellar motility; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement; multicellular organismal development; plasma membrane IPR003593; IPR011704; IPR026983; IPR026815; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; Cytoplasmic dynein 2 heavy chain 1 (Dynein heavy chain isotype 1B) DYH1B Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla) TR36526_c6_g1_i1 Q27802 DYHC2_TRIGR 0 GO:0005524; GO:0006200; GO:0016887; GO:0030031; GO:0001539; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018; GO:0007275; GO:0005886 ATP binding; ATP catabolic process; ATPase activity; cell projection assembly; ciliary or bacterial-type flagellar motility; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement; multicellular organismal development; plasma membrane IPR003593; IPR011704; IPR026983; IPR026815; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; Cytoplasmic dynein 2 heavy chain 1 (Dynein heavy chain isotype 1B) DYH1B Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla) TR36527_c0_g1_i1 Q95327 MANBA_CAPHI 5.00E-173 GO:0004567; GO:0005764; GO:0046355 beta-mannosidase activity; lysosome; mannan catabolic process IPR008979; IPR013812; IPR006102; IPR006104; IPR006103; IPR013781; IPR017853; IPR028369; Glycan metabolism; N-glycan degradation. Beta-mannosidase (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase) MANBA Capra hircus (Goat) TR36528_c1_g1_i1 Q3T197 CX056_BOVIN 2.00E-65 UPF0428 protein CXorf56 homolog Bos taurus (Bovine) TR36528_c1_g1_i6 Q3T197 CX056_BOVIN 1.00E-65 UPF0428 protein CXorf56 homolog Bos taurus (Bovine) TR36528_c2_g2_i2 Q04740 RNH1_YEAST 1.00E-13 GO:0006401; GO:0000287; GO:0003676; GO:0005634; GO:0004523 RNA catabolic process; magnesium ion binding; nucleic acid binding; nucleus; ribonuclease H activity IPR009027; IPR017067; IPR011320; IPR012337; IPR002156; Ribonuclease H (RNase H) (EC 3.1.26.4) RNH1 YMR234W YM9959.16 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR36528_c2_g2_i3 O70338 RNH1_MOUSE 5.00E-48 GO:0000287; GO:0006264; GO:0005739; GO:0003676; GO:0005634; GO:0042803; GO:0004523 magnesium ion binding; mitochondrial DNA replication; mitochondrion; nucleic acid binding; nucleus; protein homodimerization activity; ribonuclease H activity IPR009027; IPR017067; IPR011320; IPR012337; IPR002156; Ribonuclease H1 (RNase H1) (EC 3.1.26.4) Rnaseh1 Rnh1 Mus musculus (Mouse) TR36532_c1_g1_i3 P11467 DG17_DICDI 9.00E-07 GO:0005737; GO:0007275; GO:0008270 cytoplasm; multicellular organismal development; zinc ion binding IPR002083; IPR008974; IPR001841; IPR013083; IPR001293; RING finger protein DG17 (Probable TNF receptor-associated factor DDB_G0290961) zfaA DG17 DDB_G0290961 Dictyostelium discoideum (Slime mold) TR36532_c1_g1_i4 Q86AY4 Y2340_DICDI 8.00E-06 GO:0005737; GO:0004842; GO:0008270 cytoplasm; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR013323; IPR008974; IPR013083; IPR001293; TNF receptor-associated factor family protein DDB_G0272340 DDB_G0272340 Dictyostelium discoideum (Slime mold) TR36534_c0_g1_i1 Q8J1R4 TBB2_SUIBO 2.00E-44 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta-2 chain (Beta-2-tubulin) TUBB2 Suillus bovinus (Jersey cow bolete) (Boletus bovinus) TR36534_c0_g1_i3 Q9UJT0 TBE_HUMAN 0 GO:0005525; GO:0003924; GO:0007098; GO:0005874; GO:0000242; GO:0051258; GO:0005200 GTP binding; GTPase activity; centrosome cycle; microtubule; pericentriolar material; protein polymerization; structural constituent of cytoskeleton IPR004057; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin epsilon chain (Epsilon-tubulin) TUBE1 TUBE Homo sapiens (Human) TR36534_c0_g1_i5 Q9UJT0 TBE_HUMAN 9.00E-122 GO:0005525; GO:0003924; GO:0007098; GO:0005874; GO:0000242; GO:0051258; GO:0005200 GTP binding; GTPase activity; centrosome cycle; microtubule; pericentriolar material; protein polymerization; structural constituent of cytoskeleton IPR004057; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin epsilon chain (Epsilon-tubulin) TUBE1 TUBE Homo sapiens (Human) TR36536_c2_g2_i1 Q9Y5Q9 TF3C3_HUMAN 3.00E-40 GO:0042791; GO:0003677; GO:0005654; GO:0042797; GO:0000127 5S class rRNA transcription from RNA polymerase III type 1 promoter; DNA binding; nucleoplasm; tRNA transcription from RNA polymerase III promoter; transcription factor TFIIIC complex IPR013026; IPR011990; IPR001440; IPR019734; General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) GTF3C3 Homo sapiens (Human) TR36536_c3_g1_i2 Q9Y5Q9 TF3C3_HUMAN 1.00E-30 GO:0042791; GO:0003677; GO:0005654; GO:0042797; GO:0000127 5S class rRNA transcription from RNA polymerase III type 1 promoter; DNA binding; nucleoplasm; tRNA transcription from RNA polymerase III promoter; transcription factor TFIIIC complex IPR013026; IPR011990; IPR001440; IPR019734; General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) GTF3C3 Homo sapiens (Human) TR36538_c12_g1_i1 Q24733 ACT_DICVI 6.00E-15 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; Actin (Fragment) Dictyocaulus viviparus (Bovine lungworm) TR36538_c12_g2_i2 Q26065 ACT_PLAMG 0 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin, adductor muscle" Placopecten magellanicus (Sea scallop) TR36538_c12_g2_i3 P86700 ACT_CHIOP 5.00E-58 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; "Actin, muscle (Alpha-actin) (Fragments)" Chionoecetes opilio (Crab-beetle) TR36538_c12_g2_i4 P30170 ACT10_SOLTU 4.00E-138 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; Actin-85C (Fragment) AC85C Solanum tuberosum (Potato) TR36539_c0_g3_i1 O60502 NCOAT_HUMAN 5.00E-07 GO:0006044; GO:0007568; GO:0005737; GO:0046060; GO:0006516; GO:0004402; GO:0004415; GO:0070265; GO:0010616; GO:0060051; GO:0005634; GO:0051054; GO:0010524; GO:0031343; GO:0046326; GO:0060124; GO:0032024; GO:0051901; GO:0043243; GO:0045862; GO:0006612; GO:0048545 N-acetylglucosamine metabolic process; aging; cytoplasm; dATP metabolic process; glycoprotein catabolic process; histone acetyltransferase activity; hyalurononglucosaminidase activity; necrotic cell death; negative regulation of cardiac muscle adaptation; negative regulation of protein glycosylation; nucleus; positive regulation of DNA metabolic process; positive regulation of calcium ion transport into cytosol; positive regulation of cell killing; positive regulation of glucose import; positive regulation of growth hormone secretion; positive regulation of insulin secretion; positive regulation of mitochondrial depolarization; positive regulation of protein complex disassembly; positive regulation of proteolysis; protein targeting to membrane; response to steroid hormone stimulus IPR016181; IPR011496; IPR017853; Bifunctional protein NCOAT (Meningioma-expressed antigen 5) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) [Includes: Protein O-GlcNAcase (EC 3.2.1.169) (Glycoside hydrolase O-GlcNAcase) (Hexosaminidase C) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (O-GlcNAcase) (OGA); Histone acetyltransferase (HAT) (EC 2.3.1.48)] MGEA5 HEXC KIAA0679 MEA5 Homo sapiens (Human) TR36539_c0_g4_i2 Q8VIJ5 NCOAT_RAT 2.00E-167 GO:0006044; GO:0007568; GO:0004563; GO:0005737; GO:0046060; GO:0004402; GO:0070265; GO:0010616; GO:0060051; GO:0005634; GO:0051054; GO:0010524; GO:0031343; GO:0046326; GO:0060124; GO:0032024; GO:0051901; GO:0043243; GO:0045862; GO:0006612; GO:0048545 N-acetylglucosamine metabolic process; aging; beta-N-acetylhexosaminidase activity; cytoplasm; dATP metabolic process; histone acetyltransferase activity; necrotic cell death; negative regulation of cardiac muscle adaptation; negative regulation of protein glycosylation; nucleus; positive regulation of DNA metabolic process; positive regulation of calcium ion transport into cytosol; positive regulation of cell killing; positive regulation of glucose import; positive regulation of growth hormone secretion; positive regulation of insulin secretion; positive regulation of mitochondrial depolarization; positive regulation of protein complex disassembly; positive regulation of proteolysis; protein targeting to membrane; response to steroid hormone stimulus IPR016181; IPR011496; IPR017853; Bifunctional protein NCOAT (Meningioma-expressed antigen 5) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) [Includes: Beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Hexosaminidase C) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (O-GlcNAcase); Histone acetyltransferase (HAT) (EC 2.3.1.48)] Mgea5 Hexc Mea5 Rattus norvegicus (Rat) TR36539_c0_g4_i4 Q8VIJ5 NCOAT_RAT 7.00E-168 GO:0006044; GO:0007568; GO:0004563; GO:0005737; GO:0046060; GO:0004402; GO:0070265; GO:0010616; GO:0060051; GO:0005634; GO:0051054; GO:0010524; GO:0031343; GO:0046326; GO:0060124; GO:0032024; GO:0051901; GO:0043243; GO:0045862; GO:0006612; GO:0048545 N-acetylglucosamine metabolic process; aging; beta-N-acetylhexosaminidase activity; cytoplasm; dATP metabolic process; histone acetyltransferase activity; necrotic cell death; negative regulation of cardiac muscle adaptation; negative regulation of protein glycosylation; nucleus; positive regulation of DNA metabolic process; positive regulation of calcium ion transport into cytosol; positive regulation of cell killing; positive regulation of glucose import; positive regulation of growth hormone secretion; positive regulation of insulin secretion; positive regulation of mitochondrial depolarization; positive regulation of protein complex disassembly; positive regulation of proteolysis; protein targeting to membrane; response to steroid hormone stimulus IPR016181; IPR011496; IPR017853; Bifunctional protein NCOAT (Meningioma-expressed antigen 5) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) [Includes: Beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Hexosaminidase C) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (O-GlcNAcase); Histone acetyltransferase (HAT) (EC 2.3.1.48)] Mgea5 Hexc Mea5 Rattus norvegicus (Rat) TR36541_c1_g1_i1 P49588 SYAC_HUMAN 6.00E-92 GO:0005524; GO:0004813; GO:0006419; GO:0016597; GO:0002161; GO:0021680; GO:0005829; GO:0030968; GO:0001942; GO:0046872; GO:0043524; GO:0050885; GO:0006457; GO:0043200; GO:0000049; GO:0006400; GO:0008033 ATP binding; alanine-tRNA ligase activity; alanyl-tRNA aminoacylation; amino acid binding; aminoacyl-tRNA editing activity; cerebellar Purkinje cell layer development; cytosol; endoplasmic reticulum unfolded protein response; hair follicle development; metal ion binding; negative regulation of neuron apoptotic process; neuromuscular process controlling balance; protein folding; response to amino acid stimulus; tRNA binding; tRNA modification; tRNA processing IPR002318; IPR018162; IPR018165; IPR018164; IPR023033; IPR003156; IPR018163; IPR009000; IPR012947; "Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Renal carcinoma antigen NY-REN-42)" AARS Homo sapiens (Human) TR36541_c2_g1_i2 Q9VLM8 SYAC_DROME 7.00E-99 GO:0005524; GO:0004813; GO:0006419; GO:0005737; GO:0046872; GO:0000049 ATP binding; alanine-tRNA ligase activity; alanyl-tRNA aminoacylation; cytoplasm; metal ion binding; tRNA binding IPR002318; IPR018162; IPR018165; IPR018164; IPR023033; IPR003156; IPR018163; IPR009000; IPR012947; "Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)" Aats-ala alaS CG13391 Drosophila melanogaster (Fruit fly) TR36541_c2_g1_i3 Q8BGQ7 SYAC_MOUSE 6.00E-115 GO:0005524; GO:0004813; GO:0006419; GO:0016597; GO:0002161; GO:0021680; GO:0005737; GO:0030968; GO:0001942; GO:0046872; GO:0043524; GO:0050885; GO:0006457; GO:0043200; GO:0000049; GO:0006400 ATP binding; alanine-tRNA ligase activity; alanyl-tRNA aminoacylation; amino acid binding; aminoacyl-tRNA editing activity; cerebellar Purkinje cell layer development; cytoplasm; endoplasmic reticulum unfolded protein response; hair follicle development; metal ion binding; negative regulation of neuron apoptotic process; neuromuscular process controlling balance; protein folding; response to amino acid stimulus; tRNA binding; tRNA modification IPR002318; IPR018162; IPR018165; IPR018164; IPR023033; IPR003156; IPR018163; IPR009000; IPR012947; "Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)" Aars Mus musculus (Mouse) TR36541_c2_g1_i5 A1JK09 SYA_YERE8 7.00E-33 GO:0005524; GO:0004813; GO:0006419; GO:0005737; GO:0000049; GO:0008270 ATP binding; alanine-tRNA ligase activity; alanyl-tRNA aminoacylation; cytoplasm; tRNA binding; zinc ion binding IPR002318; IPR018162; IPR018165; IPR018164; IPR023033; IPR003156; IPR018163; IPR009000; IPR012947; Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) alaS YE0834 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) TR36543_c3_g1_i1 Q5RC62 BBS12_PONAB 6.00E-16 GO:0005524; GO:0044267; GO:0005929 ATP binding; cellular protein metabolic process; cilium IPR002423; IPR027409; IPR027413; Bardet-Biedl syndrome 12 protein homolog BBS12 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36546_c0_g1_i1 Q24733 ACT_DICVI 4.00E-15 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; Actin (Fragment) Dictyocaulus viviparus (Bovine lungworm) TR36546_c5_g1_i1 Q4P2E8 ARP4_USTMA 3.00E-26 GO:0006281; GO:0016568; GO:0005634; GO:0006355; GO:0006351 "DNA repair; chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR004000; IPR004001; Actin-related protein 4 (Actin-like protein ARP4) (Actin-like protein 4) ARP4 UM05715 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR36546_c5_g1_i4 O42161 ACTB_SALSA 3.00E-97 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin, cytoplasmic 1 (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]" actb Salmo salar (Atlantic salmon) TR36546_c5_g5_i1 P30170 ACT10_SOLTU 2.00E-40 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; Actin-85C (Fragment) AC85C Solanum tuberosum (Potato) TR36546_c5_g6_i3 P45888 ARP2_DROME 7.00E-44 GO:0005524; GO:0034314; GO:0005885; GO:0005884; GO:0000902; GO:0005737; GO:0007010; GO:0005200 ATP binding; Arp2/3 complex-mediated actin nucleation; Arp2/3 protein complex; actin filament; cell morphogenesis; cytoplasm; cytoskeleton organization; structural constituent of cytoskeleton IPR004000; IPR020902; IPR027306; Actin-related protein 2 (Actin-like protein 14D) (Actin-like protein 2) Arp14D Actr14D CG9901 Drosophila melanogaster (Fruit fly) TR36546_c5_g6_i4 Q92193 ACT_CRAVI 8.00E-81 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; Actin (Fragment) Crassostrea virginica (Eastern oyster) TR36546_c5_g7_i1 P84856 ACTB_CERPY 2.00E-141 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; "Actin, cytoplasmic 1 (Beta-actin)" ACTB Cercopithecus pygerythrus (Vervet monkey) TR36546_c5_g7_i2 Q93129 ACTC_BRABE 1.00E-155 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin, cytoplasmic (BbCA1) [Cleaved into: Actin, cytoplasmic, N-terminally processed]" Branchiostoma belcheri (Amphioxus) TR36546_c5_g7_i3 Q92193 ACT_CRAVI 8.00E-94 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; Actin (Fragment) Crassostrea virginica (Eastern oyster) TR36548_c2_g1_i2 Q9W0Y2 YS11_DROME 2.00E-21 GO:0016746 "transferase activity, transferring acyl groups" IPR009288; IPR013024; Putative gamma-glutamylcyclotransferase CG2811 (EC 2.3.2.-) CG2811 Drosophila melanogaster (Fruit fly) TR36548_c2_g3_i1 Q0VFX9 A2LD1_BOVIN 3.00E-16 GO:0042219; GO:0003839 cellular modified amino acid catabolic process; gamma-glutamylcyclotransferase activity IPR009288; IPR013024; Gamma-glutamylaminecyclotransferase (GGACT) (EC 2.3.2.4) (AIG2-like domain-containing protein 1) (Gamma-glutamylamine cyclotransferase) GGACT A2LD1 Bos taurus (Bovine) TR36550_c0_g2_i1 A5LFW4 EID3_MACFA 3.00E-51 GO:0006310; GO:0006281; GO:0030915; GO:0000781; GO:0005737; GO:0005634; GO:0006355; GO:0006351 "DNA recombination; DNA repair; Smc5-Smc6 complex; chromosome, telomeric region; cytoplasm; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR027786; IPR014854; EP300-interacting inhibitor of differentiation 3 (EID-3) (EID-1-like inhibitor of differentiation 3) (Non-structural maintenance of chromosomes element 4 homolog B) (NS4EB) (Non-SMC element 4 homolog B) EID3 QtsA-13676 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR36552_c0_g1_i1 Q9CXE2 BCL7A_MOUSE 5.00E-21 IPR006804; B-cell CLL/lymphoma 7 protein family member A Bcl7a Mus musculus (Mouse) TR36552_c0_g1_i2 Q5XFY4 BCL7A_DANRE 3.00E-21 IPR006804; B-cell CLL/lymphoma 7 protein family member A bcl7a zgc:92023 Danio rerio (Zebrafish) (Brachydanio rerio) TR36552_c0_g1_i4 Q5XFY4 BCL7A_DANRE 1.00E-21 IPR006804; B-cell CLL/lymphoma 7 protein family member A bcl7a zgc:92023 Danio rerio (Zebrafish) (Brachydanio rerio) TR36553_c0_g1_i3 Q5U317 FIP1_RAT 1.00E-26 GO:0003723; GO:0005847; GO:0006397 RNA binding; mRNA cleavage and polyadenylation specificity factor complex; mRNA processing IPR007854; Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1 protein) Fip1l1 Rattus norvegicus (Rat) TR36554_c0_g1_i1 P51871 CP4F6_RAT 3.00E-79 GO:0070330; GO:0005789; GO:0020037; GO:0006954; GO:0005506; GO:0006691 aromatase activity; endoplasmic reticulum membrane; heme binding; inflammatory response; iron ion binding; leukotriene metabolic process IPR001128; IPR017972; IPR002403; Cytochrome P450 4F6 (EC 1.14.14.1) (CYPIVF6) Cyp4f6 Rattus norvegicus (Rat) TR36554_c0_g2_i2 Q8N1L4 CP4Z2_HUMAN 7.00E-23 GO:0020037; GO:0016021; GO:0005506; GO:0016705 "heme binding; integral to membrane; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; Putative inactive cytochrome P450 family member 4Z2 CYP4Z2P Homo sapiens (Human) TR36554_c0_g2_i3 P33274 CP4F1_RAT 2.00E-39 GO:0050544; GO:0019369; GO:0008391; GO:0070330; GO:0005789; GO:0020037; GO:0043231; GO:0005506; GO:0009636 arachidonic acid binding; arachidonic acid metabolic process; arachidonic acid monooxygenase activity; aromatase activity; endoplasmic reticulum membrane; heme binding; intracellular membrane-bounded organelle; iron ion binding; response to toxic substance IPR001128; IPR017972; IPR002401; Cytochrome P450 4F1 (EC 1.14.14.1) (CYPIVF1) (Cytochrome P450-A3) Cyp4f1 Cyp4f-1 Cyp4f2 Rattus norvegicus (Rat) TR36555_c2_g2_i1 Q9VF26 SPNE_DROME 1.00E-19 GO:0005524; GO:0008026; GO:0043186; GO:0003724; GO:0008186; GO:0006342; GO:0046843; GO:0007294; GO:0030717; GO:0007126; GO:0046872; GO:0007076; GO:0010529; GO:0003676; GO:0005634; GO:0030720; GO:0001556; GO:0009949; GO:0009951; GO:0045451; GO:0060213; GO:0007317; GO:0007283; GO:0030423 ATP binding; ATP-dependent helicase activity; P granule; RNA helicase activity; RNA-dependent ATPase activity; chromatin silencing; dorsal appendage formation; germarium-derived oocyte fate determination; karyosome formation; meiosis; metal ion binding; mitotic chromosome condensation; negative regulation of transposition; nucleic acid binding; nucleus; oocyte localization involved in germarium-derived egg chamber formation; oocyte maturation; polarity specification of anterior/posterior axis; polarity specification of dorsal/ventral axis; pole plasm oskar mRNA localization; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; regulation of pole plasm oskar mRNA localization; spermatogenesis; targeting of mRNA for destruction involved in RNA interference IPR011545; IPR007502; IPR014001; IPR001650; IPR027417; IPR002999; IPR007087; IPR015880; Probable ATP-dependent RNA helicase spindle-E (EC 3.6.4.13) (Homeless) spn-E hls CG3158 Drosophila melanogaster (Fruit fly) TR36555_c2_g2_i3 Q9H5Z1 DHX35_HUMAN 0 GO:0005524; GO:0008026; GO:0071013; GO:0000398; GO:0003676 "ATP binding; ATP-dependent helicase activity; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nucleic acid binding" IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Probable ATP-dependent RNA helicase DHX35 (EC 3.6.4.13) (DEAH box protein 35) DHX35 C20orf15 DDX35 Homo sapiens (Human) TR36556_c0_g1_i1 Q7NDB8 RIMO_GLOVI 2.00E-23 GO:0051539; GO:0009451; GO:0005737; GO:0005506; GO:0018339; GO:0016740 "4 iron, 4 sulfur cluster binding; RNA modification; cytoplasm; iron ion binding; peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid; transferase activity" IPR006638; IPR023970; IPR005839; IPR020612; IPR013848; IPR012340; IPR005840; IPR007197; IPR023404; IPR002792; Ribosomal protein S12 methylthiotransferase RimO (S12 MTTase) (S12 methylthiotransferase) (EC 2.-.-.-) (Ribosome maturation factor RimO) rimO gll4317 Gloeobacter violaceus (strain PCC 7421) TR36556_c0_g2_i1 Q8MXQ7 CDKAL_CAEEL 4.00E-99 GO:0051539; GO:0016021; GO:0046872; GO:0008033; GO:0016740 "4 iron, 4 sulfur cluster binding; integral to membrane; metal ion binding; tRNA processing; transferase activity" IPR006638; IPR023970; IPR020612; IPR006466; IPR007197; IPR023404; IPR002792; Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.-.-.-) (CDKAL1-like protein) (tRNA-t(6)A37 methylthiotransferase) Y92H12BL.1 Caenorhabditis elegans TR36556_c0_g2_i2 Q6P4Y0 CDKAL_XENTR 2.00E-129 GO:0051539; GO:0009451; GO:0005789; GO:0016021; GO:0046872; GO:0008033; GO:0016740 "4 iron, 4 sulfur cluster binding; RNA modification; endoplasmic reticulum membrane; integral to membrane; metal ion binding; tRNA processing; transferase activity" IPR006638; IPR023970; IPR005839; IPR020612; IPR013848; IPR006466; IPR007197; IPR023404; IPR002792; Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.-.-.-) (CDK5 regulatory subunit-associated protein 1-like 1) (tRNA-t(6)A37 methylthiotransferase) cdkal1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36557_c5_g1_i1 Q8IYW2 TTC40_HUMAN 4.00E-48 IPR011990; Tetratricopeptide repeat protein 40 TTC40 C10orf123 C10orf124 C10orf92 C10orf93 Homo sapiens (Human) TR36559_c1_g1_i2 Q5F450 PAN2_CHICK 4.00E-161 GO:0031251; GO:0000932; GO:0000184; GO:0003676; GO:0005634; GO:0004535; GO:0004221; GO:0006511 "PAN complex; cytoplasmic mRNA processing body; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleic acid binding; nucleus; poly(A)-specific ribonuclease activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process" IPR006055; IPR013520; IPR001394; IPR012337; IPR015943; IPR017986; PAB-dependent poly(A)-specific ribonuclease subunit 2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) PAN2 USP52 RCJMB04_3e13 Gallus gallus (Chicken) TR36559_c1_g1_i3 Q5F450 PAN2_CHICK 3.00E-162 GO:0031251; GO:0000932; GO:0000184; GO:0003676; GO:0005634; GO:0004535; GO:0004221; GO:0006511 "PAN complex; cytoplasmic mRNA processing body; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleic acid binding; nucleus; poly(A)-specific ribonuclease activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process" IPR006055; IPR013520; IPR001394; IPR012337; IPR015943; IPR017986; PAB-dependent poly(A)-specific ribonuclease subunit 2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) PAN2 USP52 RCJMB04_3e13 Gallus gallus (Chicken) TR36561_c1_g1_i1 P0CG83 UBIQP_HORVU 4.00E-32 GO:0005737; GO:0005634 cytoplasm; nucleus IPR019956; IPR019954; IPR000626; Polyubiquitin [Cleaved into: Ubiquitin] (Fragment) Hordeum vulgare (Barley) TR36561_c1_g1_i2 P69310 UBIQ_AVESA 2.00E-19 GO:0005737; GO:0005634 cytoplasm; nucleus IPR019956; IPR019954; IPR000626; Ubiquitin Avena sativa (Oat) TR36561_c2_g1_i1 Q8JIS3 DER_CHICK 2.00E-06 GO:0042732; GO:0050038; GO:0005737; GO:0047880 D-xylose metabolic process; L-xylulose reductase (NADP+) activity; cytoplasm; erythrulose reductase activity IPR002198; IPR002347; IPR016040; IPR020904; D-erythrulose reductase (EC 1.1.1.162) (Probable L-xylulose reductase) (XR) (EC 1.1.1.10) DER Gallus gallus (Chicken) TR36561_c2_g1_i2 Q9MYP6 DHB14_BOVIN 7.00E-56 GO:0005813; GO:0005829; GO:0004303; GO:0006706; GO:0047045 centrosome; cytosol; estradiol 17-beta-dehydrogenase activity; steroid catabolic process; testosterone 17-beta-dehydrogenase (NADP+) activity IPR002198; IPR002347; IPR016040; IPR020904; 17-beta-hydroxysteroid dehydrogenase 14 (17-beta-HSD 14) (EC 1.1.1.-) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) HSD17B14 DHRS10 SDR3 Bos taurus (Bovine) TR36562_c0_g1_i2 Q94535 U2AF1_DROME 5.00E-108 GO:0005686; GO:0003729; GO:0000398; GO:0046872; GO:0007052; GO:0000166; GO:0008187; GO:0071011; GO:0000381 "U2 snRNP; mRNA binding; mRNA splicing, via spliceosome; metal ion binding; mitotic spindle organization; nucleotide binding; poly-pyrimidine tract binding; precatalytic spliceosome; regulation of alternative mRNA splicing, via spliceosome" IPR012677; IPR000504; IPR009145; IPR000571; Splicing factor U2af 38 kDa subunit (U2 auxiliary factor 38 kDa subunit) (U2 snRNP auxiliary factor small subunit) U2af38 CG3582 Drosophila melanogaster (Fruit fly) TR36562_c0_g1_i3 Q7TP17 U2AF4_RAT 5.00E-114 GO:0003723; GO:0008380; GO:0006397; GO:0046872; GO:0016607; GO:0000166; GO:0005681 RNA binding; RNA splicing; mRNA processing; metal ion binding; nuclear speck; nucleotide binding; spliceosomal complex IPR012677; IPR000504; IPR009145; IPR000571; Splicing factor U2AF 26 kDa subunit (Liver regeneration-related protein LRRG157/LRRG158) (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) U2af1l4 Cb2-806 Cb2-807 Rattus norvegicus (Rat) TR36562_c1_g1_i1 Q9HBI1 PARVB_HUMAN 4.00E-156 GO:0030018; GO:0031532; GO:0007155; GO:0034329; GO:0005856; GO:0005829; GO:0071963; GO:0005925; GO:0030027; GO:0030032; GO:0005886 Q8K4I3; Q9ES28 Z disc; actin cytoskeleton reorganization; cell adhesion; cell junction assembly; cytoskeleton; cytosol; establishment or maintenance of cell polarity regulating cell shape; focal adhesion; lamellipodium; lamellipodium assembly; plasma membrane IPR001715; Beta-parvin (Affixin) PARVB CGI-56 Homo sapiens (Human) TR36562_c1_g1_i2 Q9HBI1 PARVB_HUMAN 1.00E-155 GO:0030018; GO:0031532; GO:0007155; GO:0034329; GO:0005856; GO:0005829; GO:0071963; GO:0005925; GO:0030027; GO:0030032; GO:0005886 Q8K4I3; Q9ES28 Z disc; actin cytoskeleton reorganization; cell adhesion; cell junction assembly; cytoskeleton; cytosol; establishment or maintenance of cell polarity regulating cell shape; focal adhesion; lamellipodium; lamellipodium assembly; plasma membrane IPR001715; Beta-parvin (Affixin) PARVB CGI-56 Homo sapiens (Human) TR36569_c4_g3_i1 Q6GMK0 MGT4B_DANRE 1.00E-161 GO:0000139; GO:0008454; GO:0016021; GO:0046872; GO:0006486 "Golgi membrane; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; integral to membrane; metal ion binding; protein glycosylation" IPR006759; Protein modification; protein glycosylation. "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb) (GlcNAc-T IVb) (GnT-IVb) (N-acetylglucosaminyltransferase IVb) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb)" mgat4b zgc:92425 Danio rerio (Zebrafish) (Brachydanio rerio) TR36571_c0_g2_i1 Q5ZIM6 AATF_CHICK 2.00E-56 GO:0007155; GO:0005813; GO:0005737; GO:0040016; GO:0005925; GO:0042985; GO:0043066; GO:0032929; GO:0005730; GO:0045944; GO:0007346; GO:0006974; GO:0042254 cell adhesion; centrosome; cytoplasm; embryonic cleavage; focal adhesion; negative regulation of amyloid precursor protein biosynthetic process; negative regulation of apoptotic process; negative regulation of superoxide anion generation; nucleolus; positive regulation of transcription from RNA polymerase II promoter; regulation of mitotic cell cycle; response to DNA damage stimulus; ribosome biogenesis IPR025160; IPR012617; Protein AATF (Apoptosis-antagonizing transcription factor) AATF RCJMB04_24o4 Gallus gallus (Chicken) TR36572_c0_g1_i1 O95619 YETS4_HUMAN 3.00E-97 GO:0003677; GO:0035267; GO:0043968; GO:0043967; GO:0007067; GO:0016363; GO:0045893; GO:0040008; GO:0003700; GO:0005200; GO:0006351 O75410 "DNA binding; NuA4 histone acetyltransferase complex; histone H2A acetylation; histone H4 acetylation; mitosis; nuclear matrix; positive regulation of transcription, DNA-dependent; regulation of growth; sequence-specific DNA binding transcription factor activity; structural constituent of cytoskeleton; transcription, DNA-dependent" IPR005033; YEATS domain-containing protein 4 (Glioma-amplified sequence 41) (Gas41) (NuMA-binding protein 1) (NuBI-1) (NuBI1) YEATS4 GAS41 Homo sapiens (Human) TR36572_c0_g1_i2 O95619 YETS4_HUMAN 5.00E-98 GO:0003677; GO:0035267; GO:0043968; GO:0043967; GO:0007067; GO:0016363; GO:0045893; GO:0040008; GO:0003700; GO:0005200; GO:0006351 O75410 "DNA binding; NuA4 histone acetyltransferase complex; histone H2A acetylation; histone H4 acetylation; mitosis; nuclear matrix; positive regulation of transcription, DNA-dependent; regulation of growth; sequence-specific DNA binding transcription factor activity; structural constituent of cytoskeleton; transcription, DNA-dependent" IPR005033; YEATS domain-containing protein 4 (Glioma-amplified sequence 41) (Gas41) (NuMA-binding protein 1) (NuBI-1) (NuBI1) YEATS4 GAS41 Homo sapiens (Human) TR36573_c2_g1_i2 Q6DJ83 CADM2_XENTR 4.00E-09 GO:0016021 integral to membrane IPR013162; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; IPR003585; Cell adhesion molecule 2 (Immunoglobulin superfamily member 4D) (IgSF4D) cadm2 igsf4d Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36574_c1_g1_i1 Q53I77 XPO6A_XENLA 0 GO:0005737; GO:0006886; GO:0005634 cytoplasm; intracellular protein transport; nucleus IPR011989; IPR016024; IPR013598; IPR001494; Exportin-6-A xpo6-a Xenopus laevis (African clawed frog) TR36574_c1_g1_i2 Q8QHJ8 XPO6_DANRE 0 GO:0005737; GO:0006886; GO:0005634 cytoplasm; intracellular protein transport; nucleus IPR011989; IPR016024; IPR013598; IPR001494; Exportin-6 (Exp6) xpo6 Danio rerio (Zebrafish) (Brachydanio rerio) TR36575_c0_g1_i1 Q6INU8 TT30A_XENLA 0 GO:0005879; GO:0005929; GO:0042073; GO:0018095; GO:0005215 axonemal microtubule; cilium; intraflagellar transport; protein polyglutamylation; transporter activity IPR013026; IPR011990; IPR013105; IPR019734; Tetratricopeptide repeat protein 30A (TPR repeat protein 30A) ttc30a ttc30 Xenopus laevis (African clawed frog) TR36576_c2_g1_i1 Q91WR3 ASCC2_MOUSE 2.00E-98 GO:0006355; GO:0006351 "regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003892; IPR009060; Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100) Ascc2 Asc1p100 Mus musculus (Mouse) TR36578_c0_g2_i1 Q9WU56 TRUA_MOUSE 3.00E-100 GO:0003677; GO:0003723; GO:0030374; GO:0005739; GO:0005730; GO:0045944; GO:0009982; GO:0031119; GO:0005667 DNA binding; RNA binding; ligand-dependent nuclear receptor transcription coactivator activity; mitochondrion; nucleolus; positive regulation of transcription from RNA polymerase II promoter; pseudouridine synthase activity; tRNA pseudouridine synthesis; transcription factor complex IPR020103; IPR001406; IPR020097; IPR020095; IPR020094; "tRNA pseudouridine synthase A, mitochondrial (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I)" Pus1 MNCb-0873 Mus musculus (Mouse) TR36584_c3_g2_i3 Q32NQ7 DAAF3_XENLA 2.00E-115 GO:0070286; GO:0005737; GO:0044458 axonemal dynein complex assembly; cytoplasm; motile cilium assembly IPR028235; IPR027974; "Dynein assembly factor 3, axonemal" dnaaf3 Xenopus laevis (African clawed frog) TR36584_c3_g2_i4 D3ZCM9 DAAF3_RAT 5.00E-88 GO:0070286; GO:0005737; GO:0044458 axonemal dynein complex assembly; cytoplasm; motile cilium assembly IPR028235; IPR027974; "Dynein assembly factor 3, axonemal" Dnaaf3 Rattus norvegicus (Rat) TR36587_c0_g1_i1 Q8TB92 HMGC2_HUMAN 3.00E-151 GO:0005829; GO:0005783; GO:0005789; GO:0004419; GO:0046951; GO:0016020; GO:0046872; GO:0048471 cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; hydroxymethylglutaryl-CoA lyase activity; ketone body biosynthetic process; membrane; metal ion binding; perinuclear region of cytoplasm IPR013785; IPR027167; IPR000891; Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1. "3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic (EC 4.1.3.4) (3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1) (Endoplasmic reticulum 3-hydroxymethyl-3-methylglutaryl-CoA lyase) (er-cHL)" HMGCLL1 Homo sapiens (Human) TR36587_c0_g1_i2 Q5R9E1 HMGCL_PONAB 2.00E-153 GO:0004419; GO:0046951; GO:0046872; GO:0005759; GO:0005777 hydroxymethylglutaryl-CoA lyase activity; ketone body biosynthetic process; metal ion binding; mitochondrial matrix; peroxisome IPR013785; IPR027167; IPR000138; IPR000891; Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1. "Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)" HMGCL Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR3659_c1_g1_i1 P16157 ANK1_HUMAN 9.00E-11 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR3659_c1_g2_i1 Q8C8R3 ANK2_MOUSE 7.00E-14 GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005887; GO:0014704; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086015; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307 "M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; integral to plasma membrane; intercalated disc; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of SA node cell action potential; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Brain ankyrin) Ank2 Mus musculus (Mouse) TR36590_c3_g1_i3 Q3SZZ7 FGL1_BOVIN 4.00E-46 GO:0005576 extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein 1 FGL1 Bos taurus (Bovine) TR36590_c3_g1_i4 O00602 FCN1_HUMAN 9.00E-63 GO:0003823; GO:0005509; GO:0030246; GO:0005581; GO:0001867; GO:0005576; GO:0008228 Q2TS39 "antigen binding; calcium ion binding; carbohydrate binding; collagen; complement activation, lectin pathway; extracellular region; opsonization" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) FCN1 FCNM Homo sapiens (Human) TR36590_c3_g1_i6 A2AV25 FBCD1_MOUSE 2.00E-39 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 Fibcd1 Mus musculus (Mouse) TR36592_c2_g1_i2 P70581 NUPL1_RAT 1.00E-71 GO:0051028; GO:0031965; GO:0005643; GO:0005487; GO:0015031 mRNA transport; nuclear membrane; nuclear pore; nucleocytoplasmic transporter activity; protein transport IPR024882; Nucleoporin p58/p45 (Nucleoporin-like protein 1) Nupl1 Rattus norvegicus (Rat) TR36593_c0_g1_i1 Q90YV5 RL13_ICTPU 4.00E-77 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001380; IPR018256; 60S ribosomal protein L13 rpl13 Ictalurus punctatus (Channel catfish) (Silurus punctatus) TR36595_c0_g1_i1 Q16658 FSCN1_HUMAN 3.00E-98 GO:0051015; GO:0051017; GO:0030054; GO:0016477; GO:0008283; GO:0005829; GO:0008144; GO:0030175; GO:0071437; GO:0001725 Q9BXW9; P40692; Q9ULL4; P63104 actin filament binding; actin filament bundle assembly; cell junction; cell migration; cell proliferation; cytosol; drug binding; filopodium; invadopodium; stress fiber IPR008999; IPR010431; IPR022768; IPR024703; Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) FSCN1 FAN1 HSN SNL Homo sapiens (Human) TR36595_c0_g1_i2 Q9QXW4 FSCN3_MOUSE 1.00E-35 GO:0015629; GO:0030036; GO:0051015; GO:0005737; GO:0007286 actin cytoskeleton; actin cytoskeleton organization; actin filament binding; cytoplasm; spermatid development IPR008999; IPR010431; IPR022768; IPR024703; Fascin-3 (Testis fascin) Fscn3 Mus musculus (Mouse) TR36596_c0_g1_i1 Q297S2 DOHH_DROPS 4.00E-126 GO:0019135; GO:0042406; GO:0046872; GO:0008612 deoxyhypusine monooxygenase activity; extrinsic to endoplasmic reticulum membrane; metal ion binding; peptidyl-lysine modification to hypusine IPR011989; IPR016024; IPR027517; IPR004155; Protein modification; eIF5A hypusination. Deoxyhypusine hydroxylase (DOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase) nero l(3)s1921 GA15318 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR36597_c2_g1_i1 A4IH88 K2013_XENTR 2.00E-72 GO:0016021 integral to membrane IPR018795; Uncharacterized protein KIAA2013 homolog Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36600_c0_g1_i1 Q5XUX1 FBXW9_HUMAN 1.00E-71 P63208 IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9) FBXW9 FBW9 Homo sapiens (Human) TR36600_c0_g1_i2 Q2T9T9 FBXW9_BOVIN 6.00E-81 IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9) FBXW9 Bos taurus (Bovine) TR36602_c0_g1_i1 Q6IR74 CTL1_XENLA 3.00E-112 GO:0016021 integral to membrane IPR007603; Choline transporter-like protein 1 (Solute carrier family 44 member 1) slc44a1 ctl1 Xenopus laevis (African clawed frog) TR36602_c0_g1_i2 Q54I48 CTL2_DICDI 6.00E-90 GO:0016021 integral to membrane IPR007603; Choline transporter-like protein 2 (Solute carrier family 44 member 2) slc44a2 ctl2 DDB_G0289013 Dictyostelium discoideum (Slime mold) TR36602_c0_g2_i1 Q8VII6 CTL1_RAT 3.00E-152 GO:0016021; GO:0006810 integral to membrane; transport IPR007603; Choline transporter-like protein 1 (Solute carrier family 44 member 1) (CD antigen CD92) Slc44a1 Cd92 Cdw92 Ctl1 Rattus norvegicus (Rat) TR36602_c0_g2_i2 Q6IR74 CTL1_XENLA 4.00E-164 GO:0016021 integral to membrane IPR007603; Choline transporter-like protein 1 (Solute carrier family 44 member 1) slc44a1 ctl1 Xenopus laevis (African clawed frog) TR36602_c0_g2_i5 Q8VII6 CTL1_RAT 4.00E-29 GO:0016021; GO:0006810 integral to membrane; transport IPR007603; Choline transporter-like protein 1 (Solute carrier family 44 member 1) (CD antigen CD92) Slc44a1 Cd92 Cdw92 Ctl1 Rattus norvegicus (Rat) TR36604_c1_g1_i1 Q9BYZ6 RHBT2_HUMAN 2.00E-12 GO:0005525; GO:0005829; GO:0005886; GO:0051056; GO:0007264 GTP binding; cytosol; plasma membrane; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR000210; IPR011333; IPR013069; IPR027417; IPR001806; IPR003578; Rho-related BTB domain-containing protein 2 (Deleted in breast cancer 2 gene protein) (p83) RHOBTB2 DBC2 KIAA0717 Homo sapiens (Human) TR36604_c1_g1_i2 P17081 RHOQ_HUMAN 1.00E-44 GO:0005525; GO:0003924; GO:0005884; GO:0030866; GO:0005829; GO:0008286; GO:0045121; GO:0090005; GO:0005886; GO:0051491; GO:0046326; GO:0045944; GO:0032956; GO:0008360; GO:0051056; GO:0007264 GTP binding; GTPase activity; actin filament; cortical actin cytoskeleton organization; cytosol; insulin receptor signaling pathway; membrane raft; negative regulation of establishment of protein localization to plasma membrane; plasma membrane; positive regulation of filopodium assembly; positive regulation of glucose import; positive regulation of transcription from RNA polymerase II promoter; regulation of actin cytoskeleton organization; regulation of cell shape; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A) RHOQ ARHQ RASL7A TC10 Homo sapiens (Human) TR36604_c2_g1_i2 Q68FD5 CLH_MOUSE 2.00E-13 GO:0031523; GO:0030132; GO:0030130; GO:0003725; GO:0070062; GO:0006886; GO:0042470; GO:0030117; GO:0005739; GO:0031623; GO:0005819; GO:0090307; GO:0005198; GO:0033572 Myb complex; clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; double-stranded RNA binding; extracellular vesicular exosome; intracellular protein transport; melanosome; membrane coat; mitochondrion; receptor internalization; spindle; spindle assembly involved in mitosis; structural molecule activity; transferrin transport IPR016024; IPR000547; IPR016025; IPR015348; IPR001473; IPR022365; IPR016341; IPR011990; Clathrin heavy chain 1 Cltc Mus musculus (Mouse) TR36604_c2_g1_i3 Q4R6I5 CLHC1_MACFA 5.00E-48 IPR016024; IPR012331; IPR017212; Clathrin heavy chain linker domain-containing protein 1 CLHC1 QtsA-17948 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR36604_c2_g1_i4 Q4R6I5 CLHC1_MACFA 9.00E-28 IPR016024; IPR012331; IPR017212; Clathrin heavy chain linker domain-containing protein 1 CLHC1 QtsA-17948 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR36605_c2_g2_i1 Q9Z0K8 VNN1_MOUSE 9.00E-136 GO:0034235; GO:0002526; GO:0031225; GO:0016337; GO:0002544; GO:0045087; GO:0016021; GO:1902176; GO:0017159; GO:0015939; GO:0005886; GO:0033089 GPI anchor binding; acute inflammatory response; anchored to membrane; cell-cell adhesion; chronic inflammatory response; innate immune response; integral to membrane; negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress; pantetheine hydrolase activity; pantothenate metabolic process; plasma membrane; positive regulation of T cell differentiation in thymus IPR012101; IPR003010; Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Vascular non-inflammatory molecule 1) (Vanin-1) Vnn1 Mus musculus (Mouse) TR36605_c2_g2_i4 Q9Z0K8 VNN1_MOUSE 9.00E-137 GO:0034235; GO:0002526; GO:0031225; GO:0016337; GO:0002544; GO:0045087; GO:0016021; GO:1902176; GO:0017159; GO:0015939; GO:0005886; GO:0033089 GPI anchor binding; acute inflammatory response; anchored to membrane; cell-cell adhesion; chronic inflammatory response; innate immune response; integral to membrane; negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress; pantetheine hydrolase activity; pantothenate metabolic process; plasma membrane; positive regulation of T cell differentiation in thymus IPR012101; IPR003010; Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Vascular non-inflammatory molecule 1) (Vanin-1) Vnn1 Mus musculus (Mouse) TR36605_c2_g3_i1 Q9VR07 INE_DROME 1.00E-69 GO:0016021; GO:0005328; GO:0005034; GO:0042066; GO:0009881; GO:0005886; GO:0047484; GO:0019226 integral to membrane; neurotransmitter:sodium symporter activity; osmosensor activity; perineurial glial growth; photoreceptor activity; plasma membrane; regulation of response to osmotic stress; transmission of nerve impulse IPR000175; IPR002944; Sodium- and chloride-dependent GABA transporter ine (Protein inebriated) (Protein receptor oscillation A) ine rosA CG15444 Drosophila melanogaster (Fruit fly) TR36605_c2_g3_i2 Q9VR07 INE_DROME 6.00E-91 GO:0016021; GO:0005328; GO:0005034; GO:0042066; GO:0009881; GO:0005886; GO:0047484; GO:0019226 integral to membrane; neurotransmitter:sodium symporter activity; osmosensor activity; perineurial glial growth; photoreceptor activity; plasma membrane; regulation of response to osmotic stress; transmission of nerve impulse IPR000175; IPR002944; Sodium- and chloride-dependent GABA transporter ine (Protein inebriated) (Protein receptor oscillation A) ine rosA CG15444 Drosophila melanogaster (Fruit fly) TR36606_c0_g1_i1 P27973 POL_SIVV1 3.00E-08 GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0075713; GO:0004533; GO:0030430; GO:0042025; GO:0020002; GO:0016020; GO:0090305; GO:0006508; GO:0004523; GO:0005198; GO:0039604; GO:0046718; GO:0019013; GO:0075732; GO:0046797; GO:0008270 DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; establishment of integrated proviral latency; exoribonuclease H activity; host cell cytoplasm; host cell nucleus; host cell plasma membrane; membrane; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; structural molecule activity; suppression by virus of host translation; viral entry into host cell; viral nucleocapsid; viral penetration into host nucleus; viral procapsid maturation; zinc ion binding IPR001969; IPR000721; IPR001037; IPR001584; IPR017856; IPR003308; IPR000071; IPR012344; IPR018061; IPR001995; IPR021109; IPR008916; IPR008919; IPR010999; IPR012337; IPR002156; IPR000477; IPR010659; IPR010661; IPR001878; Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Nucleocapsid protein p7 (NC); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN)] gag-pol Simian immunodeficiency virus agm.vervet (isolate AGM155) (SIV-agm.ver) (Simian immunodeficiency virus African green monkey vervet) TR36606_c0_g2_i1 Q8T8R1 Y3800_DROME 7.00E-27 GO:0003676; GO:0008270 nucleic acid binding; zinc ion binding IPR001878; CCHC-type zinc finger protein CG3800 CG3800 Drosophila melanogaster (Fruit fly) TR36607_c1_g2_i2 O75348 VATG1_HUMAN 2.00E-14 GO:0006879; GO:0005829; GO:0016820; GO:0008286; GO:0051701; GO:0005765; GO:0090382; GO:0005886; GO:0015992; GO:0033572; GO:0055085; GO:0016471 "cellular iron ion homeostasis; cytosol; hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances; insulin receptor signaling pathway; interaction with host; lysosomal membrane; phagosome maturation; plasma membrane; proton transport; transferrin transport; transmembrane transport; vacuolar proton-transporting V-type ATPase complex" IPR005124; V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1) (Vacuolar proton pump subunit M16) ATP6V1G1 ATP6G ATP6G1 ATP6J Homo sapiens (Human) TR36607_c1_g2_i6 Q9TSV6 VATG2_PIG 9.00E-12 GO:0008553; GO:0030285; GO:0042470; GO:0016471 "hydrogen-exporting ATPase activity, phosphorylative mechanism; integral to synaptic vesicle membrane; melanosome; vacuolar proton-transporting V-type ATPase complex" IPR005124; V-type proton ATPase subunit G 2 (V-ATPase subunit G 2) (Vacuolar proton pump subunit G 2) ATP6V1G2 ATP6G2 Sus scrofa (Pig) TR36609_c1_g1_i3 Q827H4 MSOX_STRAW 5.00E-09 GO:0008442; GO:0005737; GO:0008115; GO:0046653; GO:0006573 3-hydroxyisobutyrate dehydrogenase activity; cytoplasm; sarcosine oxidase activity; tetrahydrofolate metabolic process; valine metabolic process IPR002204; IPR006076; IPR006281; Monomeric sarcosine oxidase (MSOX) (EC 1.5.3.1) soxA solA SAV_6950 Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680) TR36609_c1_g1_i4 Q29RU9 SOX_BOVIN 2.00E-07 GO:0033514; GO:0050031; GO:0005777; GO:0008115; GO:0046653 L-lysine catabolic process to acetyl-CoA via L-pipecolate; L-pipecolate oxidase activity; peroxisome; sarcosine oxidase activity; tetrahydrofolate metabolic process IPR006076; IPR006281; Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase) PIPOX Bos taurus (Bovine) TR36611_c2_g1_i1 P55201 BRPF1_HUMAN 0 GO:0003677; GO:0070776; GO:0005737; GO:0043966; GO:0005886; GO:0045893; GO:0006351; GO:0008270 "DNA binding; MOZ/MORF histone acetyltransferase complex; cytoplasm; histone H3 acetylation; plasma membrane; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001487; IPR018359; IPR019542; IPR000313; IPR019786; IPR007087; IPR015880; IPR011011; IPR001965; IPR019787; IPR013083; Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) BRPF1 BR140 Homo sapiens (Human) TR36611_c2_g1_i2 Q9ULD4 BRPF3_HUMAN 8.00E-44 GO:0070776; GO:0005829; GO:0005576; GO:0043966; GO:0030168; GO:0002576; GO:0008270 P16333 MOZ/MORF histone acetyltransferase complex; cytosol; extracellular region; histone H3 acetylation; platelet activation; platelet degranulation; zinc ion binding IPR001487; IPR018359; IPR019542; IPR000313; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Bromodomain and PHD finger-containing protein 3 BRPF3 KIAA1286 Homo sapiens (Human) TR36611_c2_g1_i3 P55201 BRPF1_HUMAN 5.00E-47 GO:0003677; GO:0070776; GO:0005737; GO:0043966; GO:0005886; GO:0045893; GO:0006351; GO:0008270 "DNA binding; MOZ/MORF histone acetyltransferase complex; cytoplasm; histone H3 acetylation; plasma membrane; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001487; IPR018359; IPR019542; IPR000313; IPR019786; IPR007087; IPR015880; IPR011011; IPR001965; IPR019787; IPR013083; Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) BRPF1 BR140 Homo sapiens (Human) TR36613_c2_g2_i1 Q25464 FP2_MYTGA 3.00E-24 GO:0005576 extracellular region IPR000742; IPR013032; IPR000152; Adhesive plaque matrix protein 2 (Foot protein 2) (MGFP-2) (MGFP2) FP2 Mytilus galloprovincialis (Mediterranean mussel) TR36613_c2_g2_i3 Q25464 FP2_MYTGA 2.00E-38 GO:0005576 extracellular region IPR000742; IPR013032; IPR000152; Adhesive plaque matrix protein 2 (Foot protein 2) (MGFP-2) (MGFP2) FP2 Mytilus galloprovincialis (Mediterranean mussel) TR36614_c0_g1_i1 Q99572 P2RX7_HUMAN 7.00E-12 GO:0005524; GO:0043132; GO:0043029; GO:0042098; GO:0000187; GO:0097190; GO:0032059; GO:0032060; GO:0000902; GO:0006884; GO:0005911; GO:0031668; GO:0046513; GO:0032963; GO:0005507; GO:0019835; GO:0005737; GO:0050830; GO:0009897; GO:0004931; GO:0048873; GO:0006954; GO:0045087; GO:0005639; GO:0005887; GO:0001530; GO:0000287; GO:0006900; GO:0051899; GO:0006509; GO:0045121; GO:0007005; GO:0044254; GO:0043409; GO:0045779; GO:0031594; GO:0043025; GO:0035872; GO:0001845; GO:0006649; GO:0045332; GO:0007009; GO:0046931; GO:0001916; GO:0043065; GO:0030501; GO:0010524; GO:0045919; GO:0051495; GO:0014054; GO:0014049; GO:0050717; GO:0050718; GO:0032755; GO:0051901; GO:0032308; GO:0043234; GO:0042803; GO:0051259; GO:0006468; GO:0016485; GO:0001614; GO:0072593; GO:0005102; GO:0019228; GO:0051709; GO:0002028; GO:0051209; GO:0033198; GO:0051592; GO:0042493; GO:0051602; GO:0034405; GO:0032496; GO:0009612; GO:0010043; GO:0019233; GO:0048705; GO:0016079; GO:0043195; GO:0008270 P00519; P62993; P16333 "ATP binding; NAD transport; T cell homeostasis; T cell proliferation; activation of MAPK activity; apoptotic signaling pathway; bleb; bleb assembly; cell morphogenesis; cell volume homeostasis; cell-cell junction; cellular response to extracellular stimulus; ceramide biosynthetic process; collagen metabolic process; copper ion binding; cytolysis; cytoplasm; defense response to Gram-positive bacterium; external side of plasma membrane; extracellular ATP-gated cation channel activity; homeostasis of number of cells within a tissue; inflammatory response; innate immune response; integral to nuclear inner membrane; integral to plasma membrane; lipopolysaccharide binding; magnesium ion binding; membrane budding; membrane depolarization; membrane protein ectodomain proteolysis; membrane raft; mitochondrion organization; multicellular organismal protein catabolic process; negative regulation of MAPK cascade; negative regulation of bone resorption; neuromuscular junction; neuronal cell body; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; phagolysosome assembly; phospholipid transfer to membrane; phospholipid translocation; plasma membrane organization; pore complex assembly; positive regulation of T cell mediated cytotoxicity; positive regulation of apoptotic process; positive regulation of bone mineralization; positive regulation of calcium ion transport into cytosol; positive regulation of cytolysis; positive regulation of cytoskeleton organization; positive regulation of gamma-aminobutyric acid secretion; positive regulation of glutamate secretion; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 production; positive regulation of mitochondrial depolarization; positive regulation of prostaglandin secretion; protein complex; protein homodimerization activity; protein oligomerization; protein phosphorylation; protein processing; purinergic nucleotide receptor activity; reactive oxygen species metabolic process; receptor binding; regulation of action potential in neuron; regulation of killing of cells of other organism; regulation of sodium ion transport; release of sequestered calcium ion into cytosol; response to ATP; response to calcium ion; response to drug; response to electrical stimulus; response to fluid shear stress; response to lipopolysaccharide; response to mechanical stimulus; response to zinc ion; sensory perception of pain; skeletal system morphogenesis; synaptic vesicle exocytosis; terminal bouton; zinc ion binding" IPR003050; IPR027309; IPR001429; P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2RX7 Homo sapiens (Human) TR36614_c1_g2_i3 Q9VF08 TIM16_DROME 6.00E-35 GO:0001700; GO:0002168; GO:0005744; GO:0022008; GO:0030150 embryonic development via the syncytial blastoderm; instar larval development; mitochondrial inner membrane presequence translocase complex; neurogenesis; protein import into mitochondrial matrix IPR005341; Mitochondrial import inner membrane translocase subunit Tim16 (Protein black pearl) blp CG5268 Drosophila melanogaster (Fruit fly) TR36615_c0_g2_i2 Q9ET78 JPH2_MOUSE 5.00E-75 GO:0030018; GO:0015278; GO:0007204; GO:0016021; GO:0030314; GO:0016020; GO:0007275; GO:0005886; GO:0060316; GO:0055024; GO:0016529; GO:0033017 Z disc; calcium-release channel activity; elevation of cytosolic calcium ion concentration; integral to membrane; junctional membrane complex; membrane; multicellular organismal development; plasma membrane; positive regulation of ryanodine-sensitive calcium-release channel activity; regulation of cardiac muscle tissue development; sarcoplasmic reticulum; sarcoplasmic reticulum membrane IPR017191; IPR003409; Junctophilin-2 (JP-2) (Junctophilin type 2) Jph2 Jp2 Mus musculus (Mouse) TR36618_c0_g1_i2 Q8N2K1 UB2J2_HUMAN 1.00E-71 GO:0005524; GO:0005789; GO:0016021; GO:0006986; GO:0004842 ATP binding; endoplasmic reticulum membrane; integral to membrane; response to unfolded protein; ubiquitin-protein ligase activity IPR000608; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 J2 (EC 6.3.2.19) (Non-canonical ubiquitin-conjugating enzyme 2) (NCUBE-2) UBE2J2 NCUBE2 Homo sapiens (Human) TR36618_c0_g1_i3 Q8IWF7 U2D2L_HUMAN 5.00E-08 GO:0016881 acid-amino acid ligase activity IPR000608; IPR016135; Putative ubiquitin-conjugating enzyme E2 D2-like protein (Ubiquitin carrier protein D2-like) (Ubiquitin-conjugating enzyme E2D N-terminal-like) (Ubiquitin-protein ligase D2-like) UBE2DNL UBE2D2L Homo sapiens (Human) TR36622_c1_g2_i1 Q6AZB8 HARB1_DANRE 2.00E-07 GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) TR36622_c6_g2_i1 B0BN95 HARB1_RAT 7.00E-14 GO:0005813; GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 centrosome; cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) Harbi1 Rattus norvegicus (Rat) TR36623_c0_g1_i1 O67178 Y1088_AQUAE 2.00E-12 GO:0008146 sulfotransferase activity IPR027417; IPR000863; IPR013026; IPR011990; IPR001440; IPR013105; IPR019734; Uncharacterized protein aq_1088 aq_1088 Aquifex aeolicus (strain VF5) TR36623_c0_g1_i2 O15294 OGT1_HUMAN 0 GO:0070688; GO:0006915; GO:0071300; GO:0005813; GO:0005829; GO:0008047; GO:0080182; GO:0043984; GO:0043981; GO:0043982; GO:0000123; GO:0005739; GO:0005547; GO:0048015; GO:0005886; GO:0030854; GO:0051571; GO:0045862; GO:0045944; GO:0016262; GO:0006493; GO:0035020; GO:0006110; GO:0046626; GO:0032868; GO:0007584 P51610; P09022; Q8IZD2; O95644; Q04206 "MLL5-L complex; apoptotic process; cellular response to retinoic acid; centrosome; cytosol; enzyme activator activity; histone H3-K4 trimethylation; histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase complex; mitochondrion; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-mediated signaling; plasma membrane; positive regulation of granulocyte differentiation; positive regulation of histone H3-K4 methylation; positive regulation of proteolysis; positive regulation of transcription from RNA polymerase II promoter; protein N-acetylglucosaminyltransferase activity; protein O-linked glycosylation; regulation of Rac protein signal transduction; regulation of glycolysis; regulation of insulin receptor signaling pathway; response to insulin stimulus; response to nutrient" IPR013026; IPR011990; IPR001440; IPR019734; Protein modification; protein glycosylation. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) OGT Homo sapiens (Human) TR36623_c0_g1_i3 Q96301 SPY_ARATH 4.00E-41 GO:0030154; GO:0009736; GO:0005829; GO:0009908; GO:0009740; GO:0009938; GO:0005634; GO:0016262; GO:0006486; GO:2000377; GO:0048511 Q9SQI2 cell differentiation; cytokinin mediated signaling pathway; cytosol; flower development; gibberellic acid mediated signaling pathway; negative regulation of gibberellic acid mediated signaling pathway; nucleus; protein N-acetylglucosaminyltransferase activity; protein glycosylation; regulation of reactive oxygen species metabolic process; rhythmic process IPR006597; IPR013026; IPR011990; IPR001440; IPR019734; Protein modification; protein glycosylation. Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY (EC 2.4.1.-) SPY At3g11540 F24K9.29 Arabidopsis thaliana (Mouse-ear cress) TR36625_c1_g1_i1 Q11100 TAG52_CAEEL 5.00E-13 GO:0005089; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; phospholipid binding; regulation of Rho protein signal transduction IPR000219; IPR011993; IPR001849; Putative protein tag-52 tag-52 C02F12.4 Caenorhabditis elegans TR36625_c1_g1_i2 Q96M96 FGD4_HUMAN 6.00E-77 GO:0005794; GO:0005089; GO:0015629; GO:0030036; GO:0097190; GO:0005829; GO:0030175; GO:0046847; GO:0005085; GO:0030027; GO:0030032; GO:0046872; GO:0030035; GO:0048011; GO:0005543; GO:0043065; GO:0043088; GO:0008360; GO:0001726; GO:0031267; GO:0007264 Golgi apparatus; Rho guanyl-nucleotide exchange factor activity; actin cytoskeleton; actin cytoskeleton organization; apoptotic signaling pathway; cytosol; filopodium; filopodium assembly; guanyl-nucleotide exchange factor activity; lamellipodium; lamellipodium assembly; metal ion binding; microspike assembly; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of apoptotic process; regulation of Cdc42 GTPase activity; regulation of cell shape; ruffle; small GTPase binding; small GTPase mediated signal transduction IPR000219; IPR011993; IPR001849; IPR000306; IPR017455; IPR013083; "FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6)" FGD4 FRABP ZFYVE6 Homo sapiens (Human) TR36625_c1_g1_i3 Q5JSP0 FGD3_HUMAN 9.00E-76 GO:0005794; GO:0005089; GO:0030036; GO:0097190; GO:0005856; GO:0005829; GO:0046847; GO:0005085; GO:0030027; GO:0046872; GO:0048011; GO:0005543; GO:0043065; GO:0043088; GO:0008360; GO:0001726; GO:0031267; GO:0007264 Golgi apparatus; Rho guanyl-nucleotide exchange factor activity; actin cytoskeleton organization; apoptotic signaling pathway; cytoskeleton; cytosol; filopodium assembly; guanyl-nucleotide exchange factor activity; lamellipodium; metal ion binding; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of apoptotic process; regulation of Cdc42 GTPase activity; regulation of cell shape; ruffle; small GTPase binding; small GTPase mediated signal transduction IPR000219; IPR011993; IPR001849; IPR000306; IPR017455; IPR011011; IPR013083; "FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5)" FGD3 ZFYVE5 Homo sapiens (Human) TR36625_c1_g3_i1 Q91WB4 PKHF2_MOUSE 9.00E-18 GO:0031901; GO:0005783; GO:0046872; GO:0005543; GO:0015031; GO:0030133 early endosome membrane; endoplasmic reticulum; metal ion binding; phospholipid binding; protein transport; transport vesicle IPR011993; IPR001849; IPR000306; IPR017455; IPR011011; IPR013083; Pleckstrin homology domain-containing family F member 2 (PH domain-containing family F member 2) Plekhf2 Mus musculus (Mouse) TR36628_c0_g1_i1 Q7TMA4 O3FA1_MOUSE 7.00E-27 GO:0030139; GO:0005504; GO:0046879; GO:0016021; GO:0050710; GO:0050728; GO:0005886; GO:0010827; GO:0008527 Q91YI4 endocytic vesicle; fatty acid binding; hormone secretion; integral to membrane; negative regulation of cytokine secretion; negative regulation of inflammatory response; plasma membrane; regulation of glucose transport; taste receptor activity IPR000276; IPR017452; Free fatty acid receptor 4 (G-protein coupled receptor 120) (G-protein coupled receptor GT01) (Omega-3 fatty acid receptor 1) Ffar4 Gpr120 O3far1 Mus musculus (Mouse) TR36629_c1_g1_i1 Q95JD5 ST1B1_CANFA 2.00E-47 GO:0004062; GO:0005737; GO:0009812; GO:0008202; GO:0051923; GO:0042403; GO:0006805 aryl sulfotransferase activity; cytoplasm; flavonoid metabolic process; steroid metabolic process; sulfation; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (cSULT1B1) (EC 2.8.2.-) SULT1B1 ST1B2 Canis familiaris (Dog) (Canis lupus familiaris) TR36631_c0_g1_i1 P43025 TETN_MOUSE 2.00E-10 GO:0030282; GO:0005509; GO:0030246; GO:0005737; GO:0005615; GO:0001652; GO:0008201; GO:0010756; GO:0005578; GO:0001501 bone mineralization; calcium ion binding; carbohydrate binding; cytoplasm; extracellular space; granular component; heparin binding; positive regulation of plasminogen activation; proteinaceous extracellular matrix; skeletal system development IPR001304; IPR016186; IPR018378; IPR016187; Tetranectin (TN) (C-type lectin domain family 3 member B) (Plasminogen kringle 4-binding protein) Clec3b Tna Mus musculus (Mouse) TR36631_c0_g1_i2 P55066 NCAN_MOUSE 2.00E-12 GO:0005509; GO:0030246; GO:0007155; GO:0005576; GO:0005540; GO:0005886; GO:0051823 calcium ion binding; carbohydrate binding; cell adhesion; extracellular region; hyaluronic acid binding; plasma membrane; regulation of synapse structural plasticity IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Neurocan core protein (Chondroitin sulfate proteoglycan 3) Ncan Cspg3 Mus musculus (Mouse) TR36631_c0_g1_i3 Q9UBG0 MRC2_HUMAN 7.00E-10 GO:0030246; GO:0006897; GO:0016021 carbohydrate binding; endocytosis; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; C-type mannose receptor 2 (C-type lectin domain family 13 member E) (Endocytic receptor 180) (Macrophage mannose receptor 2) (Urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (Urokinase receptor-associated protein) (CD antigen CD280) MRC2 CLEC13E ENDO180 KIAA0709 UPARAP Homo sapiens (Human) TR36631_c0_g1_i4 Q61282 PGCA_MOUSE 2.00E-11 GO:0005604; GO:0030246; GO:0001502; GO:0002063; GO:0030199; GO:0005540; GO:0046872; GO:0030166 basement membrane; carbohydrate binding; cartilage condensation; chondrocyte development; collagen fibril organization; hyaluronic acid binding; metal ion binding; proteoglycan biosynthetic process IPR001304; IPR016186; IPR018378; IPR016187; IPR007110; IPR013783; IPR003006; IPR013106; IPR003596; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) Acan Agc Agc1 Mus musculus (Mouse) TR36632_c0_g2_i1 Q9JJL8 SYSM_MOUSE 6.00E-25 GO:0005524; GO:0005759; GO:0005739; GO:0097056; GO:0004828; GO:0006434 ATP binding; mitochondrial matrix; mitochondrion; selenocysteinyl-tRNA(Sec) biosynthetic process; serine-tRNA ligase activity; seryl-tRNA aminoacylation IPR002314; IPR006195; IPR002317; IPR015866; IPR010978; Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1. "Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)" Sars2 Sarsm Mus musculus (Mouse) TR36633_c0_g1_i1 Q9HAR2 LPHN3_HUMAN 1.00E-42 GO:0004930; GO:0030246; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; carbohydrate binding; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR001879; IPR003924; IPR015630; IPR003334; IPR000832; IPR017983; IPR000203; IPR000922; IPR003112; Latrophilin-3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Lectomedin-3) LPHN3 KIAA0768 LEC3 Homo sapiens (Human) TR36633_c0_g1_i2 Q9QYP2 CELR2_RAT 2.00E-151 GO:0004930; GO:0005509; GO:0048813; GO:0007156; GO:0016021; GO:0007218; GO:0005886; GO:0022407; GO:0007283 G-protein coupled receptor activity; calcium ion binding; dendrite morphogenesis; homophilic cell adhesion; integral to membrane; neuropeptide signaling pathway; plasma membrane; regulation of cell-cell adhesion; spermatogenesis IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR001881; IPR013032; IPR000152; IPR002049; IPR017981; IPR001879; IPR000832; IPR000203; IPR001791; IPR001368; Cadherin EGF LAG seven-pass G-type receptor 2 (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) (Fragment) Celsr2 Megf3 Rattus norvegicus (Rat) TR36633_c0_g1_i4 Q9QYP2 CELR2_RAT 3.00E-151 GO:0004930; GO:0005509; GO:0048813; GO:0007156; GO:0016021; GO:0007218; GO:0005886; GO:0022407; GO:0007283 G-protein coupled receptor activity; calcium ion binding; dendrite morphogenesis; homophilic cell adhesion; integral to membrane; neuropeptide signaling pathway; plasma membrane; regulation of cell-cell adhesion; spermatogenesis IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR001881; IPR013032; IPR000152; IPR002049; IPR017981; IPR001879; IPR000832; IPR000203; IPR001791; IPR001368; Cadherin EGF LAG seven-pass G-type receptor 2 (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) (Fragment) Celsr2 Megf3 Rattus norvegicus (Rat) TR36633_c0_g1_i5 Q9R0M0 CELR2_MOUSE 6.00E-143 GO:0004930; GO:0016055; GO:0005509; GO:0033326; GO:0042384; GO:0003341; GO:0005737; GO:0007156; GO:0016021; GO:0021999; GO:0001764; GO:0007218; GO:0005886; GO:0032880; GO:0006355; GO:0021591 Q7T0S3 "G-protein coupled receptor activity; Wnt receptor signaling pathway; calcium ion binding; cerebrospinal fluid secretion; cilium assembly; cilium movement; cytoplasm; homophilic cell adhesion; integral to membrane; neural plate anterior/posterior regionalization; neuron migration; neuropeptide signaling pathway; plasma membrane; regulation of protein localization; regulation of transcription, DNA-dependent; ventricular system development" IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR013032; IPR000152; IPR002049; IPR017981; IPR001879; IPR000832; IPR000203; IPR009030; IPR001791; IPR001368; Cadherin EGF LAG seven-pass G-type receptor 2 (Flamingo homolog) Celsr2 Mus musculus (Mouse) TR36634_c0_g1_i1 Q5F3D7 UTP15_CHICK 8.00E-180 GO:0005737; GO:0005730; GO:0006364 cytoplasm; nucleolus; rRNA processing IPR018983; IPR015943; IPR001680; IPR019775; IPR017986; U3 small nucleolar RNA-associated protein 15 homolog UTP15 RCJMB04_20m16 Gallus gallus (Chicken) TR36634_c0_g1_i2 Q5F3D7 UTP15_CHICK 3.00E-37 GO:0005737; GO:0005730; GO:0006364 cytoplasm; nucleolus; rRNA processing IPR018983; IPR015943; IPR001680; IPR019775; IPR017986; U3 small nucleolar RNA-associated protein 15 homolog UTP15 RCJMB04_20m16 Gallus gallus (Chicken) TR36635_c2_g1_i1 Q3SZR9 TSN3_BOVIN 7.00E-07 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-3 (Tspan-3) TSPAN3 Bos taurus (Bovine) TR36635_c2_g1_i5 Q9UKR8 TSN16_HUMAN 7.00E-08 GO:0016021 integral to membrane IPR000301; IPR018499; IPR008952; Tetraspanin-16 (Tspan-16) (Tetraspanin TM4-B) (Transmembrane 4 superfamily member 16) TSPAN16 TM4SF16 Homo sapiens (Human) TR36636_c0_g1_i1 Q8VE10 NAA40_MOUSE 2.00E-75 GO:0008080; GO:0006629 N-acetyltransferase activity; lipid metabolic process IPR016181; IPR000182; N-alpha-acetyltransferase 40 (EC 2.3.1.-) (N-acetyltransferase 11) (NatD catalytic subunit) Naa40 Nat11 Mus musculus (Mouse) TR36636_c0_g1_i4 Q8VE10 NAA40_MOUSE 9.00E-77 GO:0008080; GO:0006629 N-acetyltransferase activity; lipid metabolic process IPR016181; IPR000182; N-alpha-acetyltransferase 40 (EC 2.3.1.-) (N-acetyltransferase 11) (NatD catalytic subunit) Naa40 Nat11 Mus musculus (Mouse) TR36637_c2_g1_i1 P51559 BLI4_CAEEL 2.00E-20 GO:0040002; GO:0016021; GO:0005634; GO:0006508; GO:0004252 collagen and cuticulin-based cuticle development; integral to membrane; nucleus; proteolysis; serine-type endopeptidase activity IPR006212; IPR008979; IPR009030; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Endoprotease bli-4 (EC 3.4.21.-) (Blisterase) (Blistered cuticle protein 4) bli-4 kpc-4 K04F10.4 Caenorhabditis elegans TR36637_c3_g1_i2 Q8BSK8 KS6B1_MOUSE 0 GO:0005524; GO:0000082; GO:0031929; GO:0007568; GO:0006915; GO:0030054; GO:0016477; GO:0009986; GO:0071363; GO:0032870; GO:0007281; GO:0007616; GO:0005741; GO:0005739; GO:0043066; GO:2001237; GO:0046627; GO:0043005; GO:0005634; GO:0042277; GO:0048471; GO:0045931; GO:0048633; GO:0014911; GO:0048661; GO:0045948; GO:0043491; GO:0004672; GO:0046324; GO:0042493; GO:0014878; GO:0045471; GO:0033762; GO:0051384; GO:0009749; GO:0009408; GO:0032868; GO:0043201; GO:0032496; GO:0009612; GO:0007584; GO:0033574; GO:0009636; GO:0034612; GO:0009611; GO:0004711; GO:0014732; GO:0003009; GO:0045202 P23804 ATP binding; G1/S transition of mitotic cell cycle; TOR signaling cascade; aging; apoptotic process; cell junction; cell migration; cell surface; cellular response to growth factor stimulus; cellular response to hormone stimulus; germ cell development; long-term memory; mitochondrial outer membrane; mitochondrion; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of insulin receptor signaling pathway; neuron projection; nucleus; peptide binding; perinuclear region of cytoplasm; positive regulation of mitotic cell cycle; positive regulation of skeletal muscle tissue growth; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of translational initiation; protein kinase B signaling cascade; protein kinase activity; regulation of glucose import; response to drug; response to electrical stimulus involved in regulation of muscle adaptation; response to ethanol; response to glucagon stimulus; response to glucocorticoid stimulus; response to glucose stimulus; response to heat; response to insulin stimulus; response to leucine; response to lipopolysaccharide; response to mechanical stimulus; response to nutrient; response to testosterone stimulus; response to toxic substance; response to tumor necrosis factor; response to wounding; ribosomal protein S6 kinase activity; skeletal muscle atrophy; skeletal muscle contraction; synapse IPR000961; IPR011009; IPR017892; IPR000719; IPR017441; IPR016238; IPR002290; IPR008271; Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (S6K) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) Rps6kb1 Mus musculus (Mouse) TR36637_c3_g1_i3 O14578 CTRO_HUMAN 1.00E-40 GO:0005524; GO:0015629; GO:0000910; GO:0016358; GO:0048699; GO:0035556; GO:0046872; GO:0007091; GO:0007067; GO:0000070; GO:0050774; GO:0005543; GO:0004674; GO:0001726; GO:0005083; GO:0007283; GO:0005773 ATP binding; actin cytoskeleton; cytokinesis; dendrite development; generation of neurons; intracellular signal transduction; metal ion binding; metaphase/anaphase transition of mitotic cell cycle; mitosis; mitotic sister chromatid segregation; negative regulation of dendrite morphogenesis; phospholipid binding; protein serine/threonine kinase activity; ruffle; small GTPase regulator activity; spermatogenesis; vacuole IPR000961; IPR001180; IPR017405; IPR011009; IPR011993; IPR017892; IPR001849; IPR002219; IPR000719; IPR017441; IPR020684; IPR002290; IPR008271; Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) CIT CRIK KIAA0949 STK21 Homo sapiens (Human) TR36637_c3_g1_i4 Q8BSK8 KS6B1_MOUSE 0 GO:0005524; GO:0000082; GO:0031929; GO:0007568; GO:0006915; GO:0030054; GO:0016477; GO:0009986; GO:0071363; GO:0032870; GO:0007281; GO:0007616; GO:0005741; GO:0005739; GO:0043066; GO:2001237; GO:0046627; GO:0043005; GO:0005634; GO:0042277; GO:0048471; GO:0045931; GO:0048633; GO:0014911; GO:0048661; GO:0045948; GO:0043491; GO:0004672; GO:0046324; GO:0042493; GO:0014878; GO:0045471; GO:0033762; GO:0051384; GO:0009749; GO:0009408; GO:0032868; GO:0043201; GO:0032496; GO:0009612; GO:0007584; GO:0033574; GO:0009636; GO:0034612; GO:0009611; GO:0004711; GO:0014732; GO:0003009; GO:0045202 P23804 ATP binding; G1/S transition of mitotic cell cycle; TOR signaling cascade; aging; apoptotic process; cell junction; cell migration; cell surface; cellular response to growth factor stimulus; cellular response to hormone stimulus; germ cell development; long-term memory; mitochondrial outer membrane; mitochondrion; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of insulin receptor signaling pathway; neuron projection; nucleus; peptide binding; perinuclear region of cytoplasm; positive regulation of mitotic cell cycle; positive regulation of skeletal muscle tissue growth; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of translational initiation; protein kinase B signaling cascade; protein kinase activity; regulation of glucose import; response to drug; response to electrical stimulus involved in regulation of muscle adaptation; response to ethanol; response to glucagon stimulus; response to glucocorticoid stimulus; response to glucose stimulus; response to heat; response to insulin stimulus; response to leucine; response to lipopolysaccharide; response to mechanical stimulus; response to nutrient; response to testosterone stimulus; response to toxic substance; response to tumor necrosis factor; response to wounding; ribosomal protein S6 kinase activity; skeletal muscle atrophy; skeletal muscle contraction; synapse IPR000961; IPR011009; IPR017892; IPR000719; IPR017441; IPR016238; IPR002290; IPR008271; Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (S6K) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) Rps6kb1 Mus musculus (Mouse) TR36637_c3_g1_i6 O43930 PRKY_HUMAN 3.00E-58 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR002290; IPR008271; Putative serine/threonine-protein kinase PRKY (EC 2.7.11.1) PRKY Homo sapiens (Human) TR36637_c3_g1_i7 P18654 KS6A3_MOUSE 1.00E-101 GO:0005524; GO:0007049; GO:0043027; GO:0005737; GO:0007243; GO:0000287; GO:0005634; GO:0045944; GO:0004674; GO:0032496; GO:0006950; GO:0002224 ATP binding; cell cycle; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; intracellular protein kinase cascade; magnesium ion binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; protein serine/threonine kinase activity; response to lipopolysaccharide; response to stress; toll-like receptor signaling pathway IPR000961; IPR011009; IPR017892; IPR000719; IPR017441; IPR016239; IPR002290; IPR008271; Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) Rps6ka3 Mapkapk1b Rps6ka-rs1 Rsk2 Mus musculus (Mouse) TR36638_c1_g1_i1 Q9ESX5 DKC1_MOUSE 0 GO:0015030; GO:0003723; GO:0005730; GO:0009982; GO:0004730; GO:0000154; GO:0030519; GO:0003720; GO:0005697 Cajal body; RNA binding; nucleolus; pseudouridine synthase activity; pseudouridylate synthase activity; rRNA modification; snoRNP binding; telomerase activity; telomerase holoenzyme complex IPR012960; IPR002501; IPR020103; IPR002478; IPR015947; IPR004802; IPR004521; H/ACA ribonucleoprotein complex subunit 4 (EC 5.4.99.-) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) Dkc1 Mus musculus (Mouse) TR36638_c1_g1_i2 Q9HPA4 TRUB_HALSA 1.00E-52 GO:0003723; GO:0009982; GO:0031119 RNA binding; pseudouridine synthase activity; tRNA pseudouridine synthesis IPR012960; IPR002501; IPR020103; IPR002478; IPR015947; IPR004802; IPR026326; Probable tRNA pseudouridine synthase B (EC 5.4.99.25) (tRNA pseudouridine(55) synthase) (Psi55 synthase) (tRNA pseudouridylate synthase) (tRNA-uridine isomerase) truB sus VNG_1729G Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) TR36639_c1_g1_i1 Q96KE9 BTBD6_HUMAN 3.00E-34 GO:0000932 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6 (Lens BTB domain protein) BTBD6 BDPL Homo sapiens (Human) TR36639_c1_g1_i3 Q8K2J9 BTBD6_MOUSE 4.00E-33 GO:0000932 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6 Btbd6 Mus musculus (Mouse) TR36641_c0_g1_i1 Q9UBQ7 GRHPR_HUMAN 2.00E-121 GO:0051287; GO:0070402; GO:0034641; GO:0007588; GO:0008465; GO:0046487; GO:0030267; GO:0016618; GO:0005782; GO:0042803; GO:0051259 NAD binding; NADPH binding; cellular nitrogen compound metabolic process; excretion; glycerate dehydrogenase activity; glyoxylate metabolic process; glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; peroxisomal matrix; protein homodimerization activity; protein oligomerization IPR006139; IPR006140; IPR016040; Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81) GRHPR GLXR MSTP035 Homo sapiens (Human) TR36641_c0_g1_i2 Q7VRU9 PDXB_BLOFL 7.00E-10 GO:0033711; GO:0051287; GO:0005737; GO:0008615 4-phosphoerythronate dehydrogenase activity; NAD binding; cytoplasm; pyridoxine biosynthetic process IPR006139; IPR006140; IPR020921; IPR024531; IPR016040; Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 2/5. Erythronate-4-phosphate dehydrogenase (EC 1.1.1.290) pdxB Bfl497 Blochmannia floridanus TR36641_c0_g1_i3 Q9C4M5 GYAR_THELI 2.00E-77 GO:0051287; GO:0005737; GO:0047964 NAD binding; cytoplasm; glyoxylate reductase activity IPR006139; IPR006140; IPR023519; IPR016040; Glyoxylate reductase (EC 1.1.1.26) gyaR gr Thermococcus litoralis TR36645_c0_g2_i2 Q8N357 CB018_HUMAN 1.00E-114 GO:0005794; GO:0016021; GO:0005765; GO:0005739; GO:1901029; GO:0005634; GO:0008284; GO:0006810 P05141 Golgi apparatus; integral to membrane; lysosomal membrane; mitochondrion; negative regulation of mitochondrial outer membrane permeabilization; nucleus; positive regulation of cell proliferation; transport IPR009262; IPR012404; Solute carrier family 35 member F6 (ANT2-binding protein) (ANT2BP) (Transport and Golgi organization 9 homolog) SLC35F6 C2orf18 UNQ3047/PRO9863 Homo sapiens (Human) TR36646_c0_g1_i2 Q8BS45 TTC26_MOUSE 0 GO:0042384; GO:0036064; GO:0008594; GO:0072372 cilium assembly; cilium basal body; photoreceptor cell morphogenesis; primary cilium IPR013026; IPR011990; Tetratricopeptide repeat protein 26 (TPR repeat protein 26) Ttc26 Mus musculus (Mouse) TR36646_c0_g1_i5 Q8BS45 TTC26_MOUSE 0 GO:0042384; GO:0036064; GO:0008594; GO:0072372 cilium assembly; cilium basal body; photoreceptor cell morphogenesis; primary cilium IPR013026; IPR011990; Tetratricopeptide repeat protein 26 (TPR repeat protein 26) Ttc26 Mus musculus (Mouse) TR36647_c2_g1_i1 A6QPN6 GILT_BOVIN 2.00E-42 GO:0042590; GO:0005576; GO:0005764; GO:0016667 "antigen processing and presentation of exogenous peptide antigen via MHC class I; extracellular region; lysosome; oxidoreductase activity, acting on a sulfur group of donors" IPR004911; Gamma-interferon-inducible lysosomal thiol reductase (EC 1.8.-.-) (IFI30 protein) IFI30 Bos taurus (Bovine) TR36647_c2_g1_i3 A6QPN6 GILT_BOVIN 4.00E-42 GO:0042590; GO:0005576; GO:0005764; GO:0016667 "antigen processing and presentation of exogenous peptide antigen via MHC class I; extracellular region; lysosome; oxidoreductase activity, acting on a sulfur group of donors" IPR004911; Gamma-interferon-inducible lysosomal thiol reductase (EC 1.8.-.-) (IFI30 protein) IFI30 Bos taurus (Bovine) TR36648_c0_g2_i1 Q7TSD4 TBATA_MOUSE 7.00E-07 GO:0005829; GO:0007275; GO:0005634; GO:0048515 cytosol; multicellular organismal development; nucleus; spermatid differentiation "Protein TBATA (Protein SPATIAL) (Stromal protein associated with thymii and lymph node) (Thymus, brain and testes-associated protein)" Tbata Spatial Mus musculus (Mouse) TR36648_c0_g2_i2 Q32KL8 TBATA_BOVIN 3.00E-15 GO:0030154; GO:0005829; GO:0007275; GO:0007283 cell differentiation; cytosol; multicellular organismal development; spermatogenesis "Protein TBATA (Protein SPATIAL) (Stromal protein associated with thymii and lymph node homolog) (Thymus, brain and testes-associated protein)" TBATA SPATIAL Bos taurus (Bovine) TR36648_c0_g2_i5 Q32KL8 TBATA_BOVIN 3.00E-15 GO:0030154; GO:0005829; GO:0007275; GO:0007283 cell differentiation; cytosol; multicellular organismal development; spermatogenesis "Protein TBATA (Protein SPATIAL) (Stromal protein associated with thymii and lymph node homolog) (Thymus, brain and testes-associated protein)" TBATA SPATIAL Bos taurus (Bovine) TR36649_c0_g1_i2 Q08BD8 FA54A_DANRE 2.00E-10 GO:0005739 mitochondrion IPR007972; Mitochondrial fission regulator 2 mtfr2 fam54a zgc:153910 Danio rerio (Zebrafish) (Brachydanio rerio) TR36649_c1_g2_i3 Q9UNX3 RL26L_HUMAN 4.00E-45 GO:0006614; GO:0005829; GO:0015934; GO:0000184; GO:0003735; GO:0006414; GO:0006413; GO:0006415; GO:0019083 "SRP-dependent cotranslational protein targeting to membrane; cytosol; large ribosomal subunit; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; translational elongation; translational initiation; translational termination; viral transcription" IPR005824; IPR014722; IPR005825; IPR005756; IPR008991; 60S ribosomal protein L26-like 1 RPL26L1 RPL26P1 Homo sapiens (Human) TR36651_c0_g1_i1 Q8BKC5 IPO5_MOUSE 0 GO:0006607; GO:0005737; GO:0005634; GO:0008565; GO:0006610 P70315 NLS-bearing protein import into nucleus; cytoplasm; nucleus; protein transporter activity; ribosomal protein import into nucleus IPR011989; IPR016024; IPR000357; IPR001494; Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5) Ipo5 Kpnb3 Ranbp5 Mus musculus (Mouse) TR36651_c0_g1_i2 Q8BFY9 TNPO1_MOUSE 5.00E-09 GO:0005737; GO:0006886; GO:0005634 cytoplasm; intracellular protein transport; nucleus IPR011989; IPR016024; IPR001494; Transportin-1 (Importin beta-2) (Karyopherin beta-2) Tnpo1 Kpnb2 Mus musculus (Mouse) TR36653_c0_g1_i1 Q0V8R7 NSUN4_BOVIN 1.00E-69 GO:0003723; GO:0008168; GO:0005762; GO:0006364 RNA binding; methyltransferase activity; mitochondrial large ribosomal subunit; rRNA processing IPR001678; IPR023267; 5-methylcytosine rRNA methyltransferase NSUN4 (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 4) NSUN4 Bos taurus (Bovine) TR36653_c0_g1_i2 Q9V106 TRCM_PYRAB 2.00E-20 GO:0005737; GO:0006364; GO:0016428; GO:0000049 cytoplasm; rRNA processing; tRNA (cytosine-5-)-methyltransferase activity; tRNA binding IPR001678; IPR011023; IPR023267; tRNA (cytosine(49)-C(5))-methyltransferase (EC 2.1.1.-) PYRAB06230 PAB1947 Pyrococcus abyssi (strain GE5 / Orsay) TR36653_c0_g1_i4 Q9CZ57 NSUN4_MOUSE 4.00E-75 GO:0003723; GO:0008168; GO:0005762; GO:0006364 RNA binding; methyltransferase activity; mitochondrial large ribosomal subunit; rRNA processing IPR001678; IPR023267; 5-methylcytosine rRNA methyltransferase NSUN4 (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 4) (Sperm head and tail associated protein) Nsun4 Shtap Mus musculus (Mouse) TR36657_c0_g1_i1 Q5R4R9 NDUF4_PONAB 2.00E-19 GO:0032981; GO:0005739 mitochondrial respiratory chain complex I assembly; mitochondrion IPR009622; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (Hormone-regulated proliferation-associated protein of 20 kDa homolog) (Protein HRPAP20) NDUFAF4 HRPAP20 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36657_c0_g1_i2 Q9VH39 NDUF4_DROME 4.00E-23 GO:0032981 Q9XZ68; Q9VR19; Q7JXZ2; Q9VIN1 mitochondrial respiratory chain complex I assembly IPR009622; Protein NDUFAF4 homolog CG11722 Drosophila melanogaster (Fruit fly) TR36658_c1_g1_i1 Q91XA9 CHIA_MOUSE 2.00E-119 GO:0006915; GO:0008061; GO:0006032; GO:0004568; GO:0005737; GO:0005615; GO:0000272; GO:0090197; GO:0002532 apoptotic process; chitin binding; chitin catabolic process; chitinase activity; cytoplasm; extracellular space; polysaccharide catabolic process; positive regulation of chemokine secretion; production of molecular mediator involved in inflammatory response IPR002557; IPR011583; IPR001223; IPR001579; IPR013781; IPR017853; Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (YNL) Chia Mus musculus (Mouse) TR36659_c5_g1_i2 P55809 SCOT1_HUMAN 0 GO:0008260; GO:0060612; GO:0007420; GO:0044255; GO:0071229; GO:0071333; GO:0007507; GO:0046952; GO:0042182; GO:0005759; GO:0032024; GO:0042803; GO:0014823; GO:0042493; GO:0045471; GO:0009725; GO:0007584; GO:0042594 3-oxoacid CoA-transferase activity; adipose tissue development; brain development; cellular lipid metabolic process; cellular response to acid; cellular response to glucose stimulus; heart development; ketone body catabolic process; ketone catabolic process; mitochondrial matrix; positive regulation of insulin secretion; protein homodimerization activity; response to activity; response to drug; response to ethanol; response to hormone stimulus; response to nutrient; response to starvation IPR012792; IPR012791; IPR014388; IPR004165; IPR004164; IPR004163; Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1. "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s)" OXCT1 OXCT SCOT Homo sapiens (Human) TR36659_c5_g1_i3 Q54JD9 SCOT_DICDI 0 GO:0008260; GO:0046950; GO:0046952; GO:0005739; GO:0045335 3-oxoacid CoA-transferase activity; cellular ketone body metabolic process; ketone body catabolic process; mitochondrion; phagocytic vesicle IPR012792; IPR012791; IPR014388; IPR004165; IPR004164; IPR004163; Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1. "Probable succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial (EC 2.8.3.5) (3-oxoacid CoA-transferase)" oxct1 DDB_G0288105 Dictyostelium discoideum (Slime mold) TR36662_c1_g1_i1 Q9ES45 DUOX2_RAT 0 GO:0016174; GO:0016324; GO:0005509; GO:0042335; GO:0019221; GO:0020037; GO:0042446; GO:0042744; GO:0016021; GO:0004601; GO:0051591; GO:0006590 NAD(P)H oxidase activity; apical plasma membrane; calcium ion binding; cuticle development; cytokine-mediated signaling pathway; heme binding; hormone biosynthetic process; hydrogen peroxide catabolic process; integral to membrane; peroxidase activity; response to cAMP; thyroid hormone generation IPR011992; IPR018247; IPR002048; IPR013112; IPR017927; IPR013130; IPR013121; IPR010255; IPR002007; IPR019791; IPR017938; Hormone biosynthesis; thyroid hormone biosynthesis. Dual oxidase 2 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 2) (Long NOX 2) (NADH/NADPH thyroid oxidase THOX2) (Thyroid oxidase 2) Duox2 Lnox2 Thox2 Rattus norvegicus (Rat) TR36663_c2_g7_i1 Q6AZ28 PIAS2_RAT 1.00E-127 GO:0003677; GO:0016605; GO:0019789; GO:0030521; GO:0016607; GO:0005634; GO:0050775; GO:0045893; GO:0016925; GO:0060765; GO:0033574; GO:0007283; GO:0006351; GO:0008270 "DNA binding; PML body; SUMO ligase activity; androgen receptor signaling pathway; nuclear speck; nucleus; positive regulation of dendrite morphogenesis; positive regulation of transcription, DNA-dependent; protein sumoylation; regulation of androgen receptor signaling pathway; response to testosterone stimulus; spermatogenesis; transcription, DNA-dependent; zinc ion binding" IPR027228; IPR023321; IPR003034; IPR004181; Protein modification; protein sumoylation. E3 SUMO-protein ligase PIAS2 (EC 6.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (Msx-interacting-zinc finger protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2) Pias2 Miz1 Piasx Rattus norvegicus (Rat) TR36663_c2_g7_i2 O75925 PIAS1_HUMAN 1.00E-154 GO:0003677; GO:0007259; GO:0016605; GO:0019789; GO:0050681; GO:0030521; GO:0060333; GO:0000122; GO:0016607; GO:0005654; GO:0032436; GO:0033235; GO:0051152; GO:0045893; GO:0016925; GO:0065004; GO:0042127; GO:0060334; GO:0007283; GO:0003713; GO:0003714; GO:0006351; GO:0008270 Q9UKL3; Q9UIS9; O75626; P04637 "DNA binding; JAK-STAT cascade; PML body; SUMO ligase activity; androgen receptor binding; androgen receptor signaling pathway; interferon-gamma-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nuclear speck; nucleoplasm; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein sumoylation; positive regulation of smooth muscle cell differentiation; positive regulation of transcription, DNA-dependent; protein sumoylation; protein-DNA complex assembly; regulation of cell proliferation; regulation of interferon-gamma-mediated signaling pathway; spermatogenesis; transcription coactivator activity; transcription corepressor activity; transcription, DNA-dependent; zinc ion binding" IPR027227; IPR023321; IPR003034; IPR004181; Protein modification; protein sumoylation. E3 SUMO-protein ligase PIAS1 (EC 6.3.2.-) (DEAD/H box-binding protein 1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) PIAS1 DDXBP1 Homo sapiens (Human) TR36663_c2_g7_i3 Q8N2W9 PIAS4_HUMAN 1.00E-99 GO:0003677; GO:0016605; GO:0019789; GO:0016055; GO:0005737; GO:0032088; GO:0000122; GO:0045892; GO:0016363; GO:0005634; GO:1902174; GO:0033235; GO:0016925; GO:0003714; GO:0006351; GO:0008270 Q16665; P42858; P09874; P61956; O75528; P04637 "DNA binding; PML body; SUMO ligase activity; Wnt receptor signaling pathway; cytoplasm; negative regulation of NF-kappaB transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear matrix; nucleus; positive regulation of keratinocyte apoptotic process; positive regulation of protein sumoylation; protein sumoylation; transcription corepressor activity; transcription, DNA-dependent; zinc ion binding" IPR027224; IPR023321; IPR003034; IPR004181; Protein modification; protein sumoylation. E3 SUMO-protein ligase PIAS4 (EC 6.3.2.-) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma) PIAS4 PIASG Homo sapiens (Human) TR36663_c2_g7_i4 O54714 PIAS3_MOUSE 2.00E-145 GO:0019789; GO:0005737; GO:0030425; GO:0003676; GO:0005634; GO:0010628; GO:0045838; GO:0033235; GO:0015459; GO:0016925; GO:0006355; GO:0009725; GO:0045202; GO:0006351; GO:0008270 P70338 "SUMO ligase activity; cytoplasm; dendrite; nucleic acid binding; nucleus; positive regulation of gene expression; positive regulation of membrane potential; positive regulation of protein sumoylation; potassium channel regulator activity; protein sumoylation; regulation of transcription, DNA-dependent; response to hormone stimulus; synapse; transcription, DNA-dependent; zinc ion binding" IPR027226; IPR023321; IPR003034; IPR004181; Protein modification; protein sumoylation. E3 SUMO-protein ligase PIAS3 (EC 6.3.2.-) (Protein inhibitor of activated STAT protein 3) Pias3 Mus musculus (Mouse) TR36667_c2_g4_i1 O35173 KCNS1_MOUSE 2.00E-12 GO:0005251; GO:0015459; GO:0051260; GO:0008076 delayed rectifier potassium channel activity; potassium channel regulator activity; protein homooligomerization; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003971; IPR003131; IPR028325; Potassium voltage-gated channel subfamily S member 1 (Delayed-rectifier K(+) channel alpha subunit 1) (Voltage-gated potassium channel subunit Kv9.1) Kcns1 Mus musculus (Mouse) TR36667_c2_g4_i2 P17972 KCNAW_DROME 4.00E-54 GO:0005251; GO:0051260; GO:0030431; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; sleep; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR015572; IPR003131; IPR028325; Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) TR36668_c3_g1_i4 A2AV25 FBCD1_MOUSE 1.00E-55 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 Fibcd1 Mus musculus (Mouse) TR36668_c3_g2_i3 Q8K0U4 HS12A_MOUSE 8.00E-81 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR36668_c3_g2_i5 Q9CZJ2 HS12B_MOUSE 8.00E-39 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR36669_c3_g1_i1 Q6AZB8 HARB1_DANRE 8.00E-06 GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) TR36670_c1_g1_i2 Q6DCX5 PCFT_XENLA 8.00E-28 GO:0005542; GO:0016021; GO:0055085 folic acid binding; integral to membrane; transmembrane transport IPR011701; IPR016196; Proton-coupled folate transporter (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1) slc46a1 hcp1 pcft Xenopus laevis (African clawed frog) TR36672_c1_g1_i2 Q7KRW8 PRP39_DROME 8.00E-82 GO:0005685; GO:0000398; GO:0000381 "U1 snRNP; mRNA splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome" IPR001623; IPR003107; IPR011990; Pre-mRNA-processing factor 39 (PRP39 homolog) CG1646 Drosophila melanogaster (Fruit fly) TR36672_c1_g1_i3 Q86UA1 PRP39_HUMAN 0 GO:0008380; GO:0006397; GO:0005634 RNA splicing; mRNA processing; nucleus IPR003107; IPR011990; Pre-mRNA-processing factor 39 (PRP39 homolog) PRPF39 Homo sapiens (Human) TR36672_c1_g1_i4 Q86UA1 PRP39_HUMAN 0 GO:0008380; GO:0006397; GO:0005634 RNA splicing; mRNA processing; nucleus IPR003107; IPR011990; Pre-mRNA-processing factor 39 (PRP39 homolog) PRPF39 Homo sapiens (Human) TR36673_c1_g1_i1 P0C6F1 DYH2_MOUSE 0 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR026976; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 2, axonemal (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2)" Dnah2 Dnahc2 Mus musculus (Mouse) TR36673_c4_g1_i1 P0C6F1 DYH2_MOUSE 2.00E-103 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR026976; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 2, axonemal (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2)" Dnah2 Dnahc2 Mus musculus (Mouse) TR36679_c2_g1_i1 Q6GP28 SRPX2_XENLA 6.00E-08 GO:0001525; GO:0007155; GO:0005737; GO:0005576 angiogenesis; cell adhesion; cytoplasm; extracellular region IPR025232; IPR003410; IPR000436; Sushi repeat-containing protein SRPX2 srpx2 Xenopus laevis (African clawed frog) TR36679_c3_g1_i1 Q0VCX1 C1S_BOVIN 3.00E-06 GO:0005509; GO:0006958; GO:0005576; GO:0045087; GO:0006508; GO:0004252 "calcium ion binding; complement activation, classical pathway; extracellular region; innate immune response; proteolysis; serine-type endopeptidase activity" IPR000859; IPR001881; IPR000152; IPR018097; IPR024175; IPR001254; IPR018114; IPR001314; IPR000436; IPR009003; Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain] C1S Bos taurus (Bovine) TR36679_c3_g1_i4 P16581 LYAM2_HUMAN 2.00E-25 GO:0030029; GO:0007202; GO:0007596; GO:0019722; GO:0005901; GO:0005905; GO:0030863; GO:0005615; GO:0007157; GO:0016021; GO:0002523; GO:0050901; GO:0070492; GO:0048471; GO:0043274; GO:0002687; GO:0002092; GO:0050727; GO:0070555; GO:0032496; GO:0034612; GO:0033691; GO:0004888 actin filament-based process; activation of phospholipase C activity; blood coagulation; calcium-mediated signaling; caveola; coated pit; cortical cytoskeleton; extracellular space; heterophilic cell-cell adhesion; integral to membrane; leukocyte migration involved in inflammatory response; leukocyte tethering or rolling; oligosaccharide binding; perinuclear region of cytoplasm; phospholipase binding; positive regulation of leukocyte migration; positive regulation of receptor internalization; regulation of inflammatory response; response to interleukin-1; response to lipopolysaccharide; response to tumor necrosis factor; sialic acid binding; transmembrane signaling receptor activity IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR002396; IPR000436; E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E) SELE ELAM1 Homo sapiens (Human) TR36679_c3_g1_i6 P17927 CR1_HUMAN 9.00E-12 GO:0009986; GO:0006958; GO:0001851; GO:0004877; GO:0001855; GO:0001861; GO:0045087; GO:0005887; GO:0045957; GO:0045959; GO:1900004; GO:1900005 "cell surface; complement activation, classical pathway; complement component C3b binding; complement component C3b receptor activity; complement component C4b binding; complement component C4b receptor activity; innate immune response; integral to plasma membrane; negative regulation of complement activation, alternative pathway; negative regulation of complement activation, classical pathway; negative regulation of serine-type endopeptidase activity; positive regulation of serine-type endopeptidase activity" IPR000436; Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35) CR1 C3BR Homo sapiens (Human) TR36679_c3_g2_i1 P08174 DAF_HUMAN 2.00E-16 GO:0031225; GO:0016324; GO:0009986; GO:0006958; GO:0007204; GO:0004857; GO:0005576; GO:0045087; GO:0005887; GO:0060137; GO:0045121; GO:0045916; GO:0030449; GO:0045730; GO:0043434; GO:0009615; GO:0007283; GO:0001618 "anchored to membrane; apical plasma membrane; cell surface; complement activation, classical pathway; elevation of cytosolic calcium ion concentration; enzyme inhibitor activity; extracellular region; innate immune response; integral to plasma membrane; maternal process involved in parturition; membrane raft; negative regulation of complement activation; regulation of complement activation; respiratory burst; response to peptide hormone stimulus; response to virus; spermatogenesis; virus receptor activity" IPR000436; Complement decay-accelerating factor (CD antigen CD55) CD55 CR DAF Homo sapiens (Human) TR36679_c3_g2_i2 Q9JJS8 MASP2_RAT 1.00E-07 GO:0005509; GO:0006958; GO:0005576; GO:0045087; GO:0006508; GO:0004252 "calcium ion binding; complement activation, classical pathway; extracellular region; innate immune response; proteolysis; serine-type endopeptidase activity" IPR000859; IPR001881; IPR013032; IPR018097; IPR024175; IPR001254; IPR018114; IPR001314; IPR000436; IPR009003; Mannan-binding lectin serine protease 2 (EC 3.4.21.104) (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain] Masp2 Rattus norvegicus (Rat) TR36679_c3_g4_i1 P00735 THRB_BOVIN 4.00E-07 GO:0006953; GO:0005509; GO:0007166; GO:0051480; GO:0005615; GO:0042730; GO:0048712; GO:0045861; GO:0030168; GO:0030194; GO:0030307; GO:0008284; GO:0032967; GO:0014068; GO:1900738; GO:0001934; GO:2000379; GO:0051281; GO:0006508; GO:0008360; GO:0010468; GO:0004252; GO:0070053 Q4W8J9 acute-phase response; calcium ion binding; cell surface receptor signaling pathway; cytosolic calcium ion homeostasis; extracellular space; fibrinolysis; negative regulation of astrocyte differentiation; negative regulation of proteolysis; platelet activation; positive regulation of blood coagulation; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway; positive regulation of protein phosphorylation; positive regulation of reactive oxygen species metabolic process; positive regulation of release of sequestered calcium ion into cytosol; proteolysis; regulation of cell shape; regulation of gene expression; serine-type endopeptidase activity; thrombospondin receptor activity IPR017857; IPR000294; IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR003966; IPR018992; IPR009003; Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] F2 Bos taurus (Bovine) TR36679_c3_g4_i2 O18783 PLMN_MACEU 6.00E-10 GO:0007596; GO:0005576; GO:0042730; GO:0006508; GO:0004252; GO:0048771 blood coagulation; extracellular region; fibrinolysis; proteolysis; serine-type endopeptidase activity; tissue remodeling IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Macropus eugenii (Tammar wallaby) TR36679_c3_g4_i3 P49150 URTG_DESRO 1.00E-07 GO:0005576; GO:0006508; GO:0004252 extracellular region; proteolysis; serine-type endopeptidase activity IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR009003; Salivary plasminogen activator gamma (EC 3.4.21.68) (DSPA gamma) Desmodus rotundus (Vampire bat) TR36679_c3_g4_i4 P98119 URT1_DESRO 7.00E-07 GO:0005576; GO:0006508; GO:0004252 extracellular region; proteolysis; serine-type endopeptidase activity IPR000742; IPR013032; IPR000083; IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR009003; Salivary plasminogen activator alpha 1 (EC 3.4.21.68) (DSPA alpha-1) Desmodus rotundus (Vampire bat) TR36679_c3_g5_i1 P12545 PLMN_MACMU 1.00E-11 GO:0007596; GO:0005576; GO:0042730; GO:0006508; GO:0004252; GO:0048771 blood coagulation; extracellular region; fibrinolysis; proteolysis; serine-type endopeptidase activity; tissue remodeling IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Macaca mulatta (Rhesus macaque) TR36679_c3_g5_i3 P06868 PLMN_BOVIN 4.00E-11 GO:0007596; GO:0005576; GO:0042730; GO:0006508; GO:0004252; GO:0048771 blood coagulation; extracellular region; fibrinolysis; proteolysis; serine-type endopeptidase activity; tissue remodeling IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Bos taurus (Bovine) TR36679_c4_g1_i1 Q4LDE5 SVEP1_HUMAN 8.00E-09 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) TR36681_c0_g1_i2 O15232 MATN3_HUMAN 6.00E-20 GO:0030198; GO:0005201; GO:0005578; GO:0001501 extracellular matrix organization; extracellular matrix structural constituent; proteinaceous extracellular matrix; skeletal system development IPR000742; IPR013032; IPR009030; IPR019466; IPR002035; Matrilin-3 MATN3 Homo sapiens (Human) TR36681_c1_g1_i1 Q66PY1 SCUB3_MOUSE 6.00E-73 GO:0005509; GO:0009986; GO:0005576; GO:0051291; GO:0051260 calcium ion binding; cell surface; extracellular region; protein heterooligomerization; protein homooligomerization IPR026823; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR011641; "Signal peptide, CUB and EGF-like domain-containing protein 3" Scube3 Mus musculus (Mouse) TR36681_c2_g3_i1 Q5G872 SCUB2_DANRE 1.00E-109 GO:0008015; GO:0005509; GO:0009897; GO:0005615; GO:0042694; GO:0048747; GO:0007517; GO:0030514; GO:0030141; GO:0007224; GO:0001756 blood circulation; calcium ion binding; external side of plasma membrane; extracellular space; muscle cell fate specification; muscle fiber development; muscle organ development; negative regulation of BMP signaling pathway; secretory granule; smoothened signaling pathway; somitogenesis IPR026823; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR011641; "Signal peptide, CUB and EGF-like domain-containing protein 2 (Protein You)" scube2 you Danio rerio (Zebrafish) (Brachydanio rerio) TR36681_c2_g3_i2 Q4LDE5 SVEP1_HUMAN 1.00E-21 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) TR36682_c0_g1_i1 A5D8M0 TYDP2_XENLA 4.00E-76 GO:0070260; GO:0016605; GO:0006302; GO:0000287; GO:0030145; GO:0004518; GO:0090305; GO:0003697 5'-tyrosyl-DNA phosphodiesterase activity; PML body; double-strand break repair; magnesium ion binding; manganese ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; single-stranded DNA binding IPR005135; IPR009060; Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (TRAF and TNF receptor-associated protein homolog) tdp2 ttrap Xenopus laevis (African clawed frog) TR36682_c0_g1_i3 Q28FQ5 TYDP2_XENTR 1.00E-71 GO:0070260; GO:0016605; GO:0006302; GO:0000287; GO:0030145; GO:0004518; GO:0090305; GO:0003697 5'-tyrosyl-DNA phosphodiesterase activity; PML body; double-strand break repair; magnesium ion binding; manganese ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; single-stranded DNA binding IPR005135; IPR009060; Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (TRAF and TNF receptor-associated protein homolog) tdp2 ttrap TGas102g02.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36682_c0_g1_i4 O95551 TYDP2_HUMAN 2.00E-72 GO:0070260; GO:0016605; GO:0007166; GO:0005737; GO:0006302; GO:0000287; GO:0030145; GO:0004518; GO:0090305; GO:0005730; GO:0003697; GO:0003714; GO:0036317 5'-tyrosyl-DNA phosphodiesterase activity; PML body; cell surface receptor signaling pathway; cytoplasm; double-strand break repair; magnesium ion binding; manganese ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleolus; single-stranded DNA binding; transcription corepressor activity; tyrosyl-RNA phosphodiesterase activity IPR005135; IPR009060; Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase) TDP2 EAP2 TTRAP AD-022 Homo sapiens (Human) TR36683_c2_g2_i3 Q5RJL6 METRL_RAT 6.00E-15 GO:0005576 extracellular region Meteorin-like protein Metrnl Rattus norvegicus (Rat) TR36683_c3_g3_i1 B2RXS4 PLXB2_MOUSE 2.00E-14 GO:0007420; GO:0005887; GO:0005622; GO:0001843; GO:0007405; GO:0050772; GO:0032319; GO:0008360; GO:2001222; GO:0001932; GO:0017154 Q68FM7 brain development; integral to plasma membrane; intracellular; neural tube closure; neuroblast proliferation; positive regulation of axonogenesis; regulation of Rho GTPase activity; regulation of cell shape; regulation of neuron migration; regulation of protein phosphorylation; semaphorin receptor activity IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-B2 Plxnb2 Mus musculus (Mouse) TR36683_c3_g3_i2 D3ZPX4 PLXA3_RAT 3.00E-32 GO:0007411; GO:0021766; GO:0016021; GO:0005622; GO:0050919; GO:0048843; GO:0005886; GO:0051495; GO:0021860; GO:0017154 axon guidance; hippocampus development; integral to membrane; intracellular; negative chemotaxis; negative regulation of axon extension involved in axon guidance; plasma membrane; positive regulation of cytoskeleton organization; pyramidal neuron development; semaphorin receptor activity IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A3 Plxna3 Rattus norvegicus (Rat) TR36683_c3_g3_i4 D3ZPX4 PLXA3_RAT 1.00E-44 GO:0007411; GO:0021766; GO:0016021; GO:0005622; GO:0050919; GO:0048843; GO:0005886; GO:0051495; GO:0021860; GO:0017154 axon guidance; hippocampus development; integral to membrane; intracellular; negative chemotaxis; negative regulation of axon extension involved in axon guidance; plasma membrane; positive regulation of cytoskeleton organization; pyramidal neuron development; semaphorin receptor activity IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A3 Plxna3 Rattus norvegicus (Rat) TR36684_c0_g2_i3 P25326 CATS_BOVIN 2.00E-61 GO:0002250; GO:0097067; GO:0008234; GO:0005764; GO:0016020; GO:0006508 adaptive immune response; cellular response to thyroid hormone stimulus; cysteine-type peptidase activity; lysosome; membrane; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin S (EC 3.4.22.27) CTSS Bos taurus (Bovine) TR36684_c0_g2_i4 P43233 CATB_CHICK 1.00E-06 GO:0004197; GO:0005764; GO:0006508; GO:0050790 cysteine-type endopeptidase activity; lysosome; proteolysis; regulation of catalytic activity IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR012599; Cathepsin B (EC 3.4.22.1) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] CTSB Gallus gallus (Chicken) TR36684_c0_g2_i5 Q54TR1 CFAD_DICDI 3.00E-97 GO:0031410; GO:0005576; GO:0008285; GO:0031288 cytoplasmic vesicle; extracellular region; negative regulation of cell proliferation; sorocarp morphogenesis IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Counting factor associated protein D cfaD DDB_G0281605 Dictyostelium discoideum (Slime mold) TR36687_c0_g1_i1 Q6P474 PDXD2_HUMAN 5.00E-60 GO:0016831; GO:0019752; GO:0030170 carboxy-lyase activity; carboxylic acid metabolic process; pyridoxal phosphate binding IPR002129; IPR015424; IPR015421; IPR015422; Putative pyridoxal-dependent decarboxylase domain-containing protein 2 (EC 4.1.1.-) (pyridoxal-dependent decarboxylase domain-containing 2 pseudogene) PDXDC2P PDXDC2 Homo sapiens (Human) TR36688_c0_g1_i2 P79769 TSN_CHICK 4.00E-87 GO:0003723; GO:0004519; GO:0090305; GO:0005634; GO:0043565 RNA binding; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus; sequence-specific DNA binding IPR002848; IPR016069; IPR016068; Translin (EC 3.1.-.-) (Component 3 of promoter of RISC) (C3PO) TSN Gallus gallus (Chicken) TR36689_c1_g1_i2 Q6DDL7 UN93A_XENLA 1.00E-134 GO:0016021 integral to membrane IPR010291; IPR016196; Protein unc-93 homolog A (Unc-93A) unc93a Xenopus laevis (African clawed frog) TR36690_c5_g1_i1 O08914 FAAH1_MOUSE 8.00E-102 GO:0000139; GO:0047372; GO:0016884; GO:0005789; GO:0017064; GO:0009062; GO:0016021; GO:0031090 "Golgi membrane; acylglycerol lipase activity; carbon-nitrogen ligase activity, with glutamine as amido-N-donor; endoplasmic reticulum membrane; fatty acid amide hydrolase activity; fatty acid catabolic process; integral to membrane; organelle membrane" IPR000120; IPR020556; IPR023631; IPR015830; Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidohydrolase 1) (Oleamide hydrolase 1) Faah Faah1 Mus musculus (Mouse) TR36690_c7_g1_i1 P85442 VGLL3_MOUSE 4.00E-12 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006627; IPR011520; Transcription cofactor vestigial-like protein 3 (Vgl-3) Vgll3 Mus musculus (Mouse) TR36690_c7_g1_i2 Q8BGW8 VGLL2_MOUSE 5.00E-15 GO:0005737; GO:0005634; GO:0045944; GO:0007519; GO:0003713; GO:0006351 "cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter; skeletal muscle tissue development; transcription coactivator activity; transcription, DNA-dependent" IPR011520; Transcription cofactor vestigial-like protein 2 (Vgl-2) (Protein VITO1) Vgll2 Vgl2 Vito1 Mus musculus (Mouse) TR36691_c6_g2_i1 Q95V84 RL38_BRABE 2.00E-25 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR002675; 60S ribosomal protein L38 RPL38 Branchiostoma belcheri (Amphioxus) TR36691_c7_g2_i2 Q5NVM8 RNPS1_PONAB 3.00E-31 GO:0061574; GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0048025; GO:0016607; GO:0000184; GO:0000166; GO:0043065; GO:0000381 "ASAP complex; RNA binding; RNA splicing; cytoplasm; mRNA processing; negative regulation of mRNA splicing, via spliceosome; nuclear speck; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleotide binding; positive regulation of apoptotic process; regulation of alternative mRNA splicing, via spliceosome" IPR012677; IPR000504; RNA-binding protein with serine-rich domain 1 RNPS1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36694_c3_g3_i1 Q8MV48 GALT7_DROME 0 GO:0000139; GO:0005795; GO:0016021; GO:0009312; GO:0004653; GO:0006486 Golgi membrane; Golgi stack; integral to membrane; oligosaccharide biosynthetic process; polypeptide N-acetylgalactosaminyltransferase activity; protein glycosylation IPR001173; IPR000772; Protein modification; protein glycosylation. N-acetylgalactosaminyltransferase 7 (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase 7) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7) (pp-GaNTase 7) (dGalNAc-T2) GalNAc-T2 pgant7 CG6394 Drosophila melanogaster (Fruit fly) TR36695_c0_g2_i3 F7FIH8 NNRE_MONDO 9.00E-107 GO:0044297; GO:0005929; GO:0005615; GO:0016853; GO:0046872; GO:0005739; GO:0000166; GO:0051289 cell body; cilium; extracellular space; isomerase activity; metal ion binding; mitochondrion; nucleotide binding; protein homotetramerization IPR026600; IPR004443; NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) APOA1BP AIBP Monodelphis domestica (Gray short-tailed opossum) TR36695_c0_g2_i4 Q6DHK1 NNRE_DANRE 1.00E-108 GO:0005576; GO:0016853; GO:0046872; GO:0005739; GO:0000166 extracellular region; isomerase activity; metal ion binding; mitochondrion; nucleotide binding IPR026600; IPR004443; NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) apoa1bp aibp si:dkeyp-84f11.6 zgc:92263 Danio rerio (Zebrafish) (Brachydanio rerio) TR36695_c0_g2_i6 F7FIH8 NNRE_MONDO 9.00E-107 GO:0044297; GO:0005929; GO:0005615; GO:0016853; GO:0046872; GO:0005739; GO:0000166; GO:0051289 cell body; cilium; extracellular space; isomerase activity; metal ion binding; mitochondrion; nucleotide binding; protein homotetramerization IPR026600; IPR004443; NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) APOA1BP AIBP Monodelphis domestica (Gray short-tailed opossum) TR36696_c0_g1_i1 Q5R792 ATG5_PONAB 4.00E-98 GO:0006915; GO:0005776; GO:0000045; GO:0001974; GO:0060047; GO:0045087; GO:0043066; GO:0031397; GO:0048840; GO:0043687; GO:0034045; GO:0002739; GO:0042493; GO:0009620; GO:0042311; GO:0055015 apoptotic process; autophagic vacuole; autophagic vacuole assembly; blood vessel remodeling; heart contraction; innate immune response; negative regulation of apoptotic process; negative regulation of protein ubiquitination; otolith development; post-translational protein modification; pre-autophagosomal structure membrane; regulation of cytokine secretion involved in immune response; response to drug; response to fungus; vasodilation; ventricular cardiac muscle cell development IPR007239; Autophagy protein 5 (APG5-like) ATG5 APG5L Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36696_c0_g1_i2 Q2UBM1 ATG5_ASPOR 2.00E-26 GO:0006914; GO:0034045; GO:0015031 autophagy; pre-autophagosomal structure membrane; protein transport IPR007239; Autophagy protein 5 atg5 AO090012000943 Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) TR36698_c0_g1_i1 Q0VCR6 TMM68_BOVIN 9.00E-108 GO:0016021; GO:0016746 "integral to membrane; transferase activity, transferring acyl groups" IPR002123; Transmembrane protein 68 TMEM68 Bos taurus (Bovine) TR36699_c0_g1_i1 Q5ZLR7 TM251_CHICK 5.00E-19 GO:0016021 integral to membrane IPR028024; Transmembrane protein 251 TMEM251 RCJMB04_5b13 Gallus gallus (Chicken) TR36699_c0_g1_i2 Q5ZLR7 TM251_CHICK 3.00E-10 GO:0016021 integral to membrane IPR028024; Transmembrane protein 251 TMEM251 RCJMB04_5b13 Gallus gallus (Chicken) TR367_c0_g1_i1 P46088 GST_OMMSL 5.00E-49 GO:0005737; GO:0004364 cytoplasm; glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR003083; IPR012336; Glutathione S-transferase (EC 2.5.1.18) (GST class-sigma) Ommastrephes sloanei (Arrow squid) (Sloane's squid) TR36701_c5_g1_i4 Q57997 Y577_METJA 8.00E-11 GO:0005524; GO:0005737; GO:0006950 ATP binding; cytoplasm; response to stress IPR014729; IPR006015; IPR006016; Universal stress protein MJ0577 (USP MJ0577) MJ0577 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR36701_c5_g1_i6 P42297 YXIE_BACSU 8.00E-08 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein YxiE (USP YxiE) yxiE BSU39250 N17E Bacillus subtilis (strain 168) TR36702_c1_g1_i1 P37837 TALDO_HUMAN 5.00E-109 GO:0005829; GO:0006112; GO:0006098; GO:0004801; GO:0005999 cytosol; energy reserve metabolic process; pentose-phosphate shunt; sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity; xylulose biosynthetic process IPR013785; IPR001585; IPR004730; IPR018225; Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3. Transaldolase (EC 2.2.1.2) TALDO1 TAL TALDO TALDOR Homo sapiens (Human) TR36702_c1_g1_i3 P37837 TALDO_HUMAN 1.00E-97 GO:0005829; GO:0006112; GO:0006098; GO:0004801; GO:0005999 cytosol; energy reserve metabolic process; pentose-phosphate shunt; sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity; xylulose biosynthetic process IPR013785; IPR001585; IPR004730; IPR018225; Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3. Transaldolase (EC 2.2.1.2) TALDO1 TAL TALDO TALDOR Homo sapiens (Human) TR36704_c0_g2_i1 Q8N371 KDM8_HUMAN 2.00E-14 GO:0000086; GO:0003682; GO:0051864; GO:0046872; GO:0005634; GO:0045893; GO:0006351 "G2/M transition of mitotic cell cycle; chromatin binding; histone demethylase activity (H3-K36 specific); metal ion binding; nucleus; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003347; Lysine-specific demethylase 8 (EC 1.14.11.27) (JmjC domain-containing protein 5) (Jumonji domain-containing protein 5) KDM8 JMJD5 Homo sapiens (Human) TR36704_c0_g2_i2 Q8N371 KDM8_HUMAN 1.00E-14 GO:0000086; GO:0003682; GO:0051864; GO:0046872; GO:0005634; GO:0045893; GO:0006351 "G2/M transition of mitotic cell cycle; chromatin binding; histone demethylase activity (H3-K36 specific); metal ion binding; nucleus; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003347; Lysine-specific demethylase 8 (EC 1.14.11.27) (JmjC domain-containing protein 5) (Jumonji domain-containing protein 5) KDM8 JMJD5 Homo sapiens (Human) TR36706_c0_g1_i4 Q6PAF4 NSE1_XENLA 3.00E-59 GO:0006310; GO:0006281; GO:0030915; GO:0000781; GO:0046872; GO:0005634; GO:2001022; GO:0004842 "DNA recombination; DNA repair; Smc5-Smc6 complex; chromosome, telomeric region; metal ion binding; nucleus; positive regulation of response to DNA damage stimulus; ubiquitin-protein ligase activity" IPR011513; IPR014857; Non-structural maintenance of chromosomes element 1 homolog (Non-SMC element 1 homolog) (EC 6.3.2.-) nsmce1 Xenopus laevis (African clawed frog) TR36706_c0_g1_i5 Q6PAF4 NSE1_XENLA 3.00E-59 GO:0006310; GO:0006281; GO:0030915; GO:0000781; GO:0046872; GO:0005634; GO:2001022; GO:0004842 "DNA recombination; DNA repair; Smc5-Smc6 complex; chromosome, telomeric region; metal ion binding; nucleus; positive regulation of response to DNA damage stimulus; ubiquitin-protein ligase activity" IPR011513; IPR014857; Non-structural maintenance of chromosomes element 1 homolog (Non-SMC element 1 homolog) (EC 6.3.2.-) nsmce1 Xenopus laevis (African clawed frog) TR36707_c1_g2_i1 Q5UR46 YR571_MIMIV 9.00E-15 GO:0016787; GO:0016021; GO:0016042 hydrolase activity; integral to membrane; lipid catabolic process IPR016035; IPR002641; Uncharacterized protein R571 (EC 3.1.1.-) MIMI_R571 Acanthamoeba polyphaga mimivirus (APMV) TR36707_c1_g2_i2 Q5UR46 YR571_MIMIV 1.00E-14 GO:0016787; GO:0016021; GO:0016042 hydrolase activity; integral to membrane; lipid catabolic process IPR016035; IPR002641; Uncharacterized protein R571 (EC 3.1.1.-) MIMI_R571 Acanthamoeba polyphaga mimivirus (APMV) TR36708_c0_g1_i3 Q62186 SSRD_MOUSE 1.00E-43 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR008855; Translocon-associated protein subunit delta (TRAP-delta) (Signal sequence receptor subunit delta) (SSR-delta) Ssr4 Mus musculus (Mouse) TR36709_c1_g4_i1 Q32LJ2 ARFRP_BOVIN 4.00E-93 GO:0005525; GO:0005794; GO:0043001; GO:0034067; GO:0042147; GO:0007264; GO:0005802 "GTP binding; Golgi apparatus; Golgi to plasma membrane protein transport; protein localization to Golgi apparatus; retrograde transport, endosome to Golgi; small GTPase mediated signal transduction; trans-Golgi network" IPR027417; IPR005225; IPR001806; IPR024156; IPR006689; ADP-ribosylation factor-related protein 1 (ARF-related protein 1) ARFRP1 Bos taurus (Bovine) TR36709_c1_g4_i2 Q5R579 ARFRP_PONAB 7.00E-91 GO:0005525; GO:0005794; GO:0043001; GO:0034067; GO:0042147; GO:0007264; GO:0005802 "GTP binding; Golgi apparatus; Golgi to plasma membrane protein transport; protein localization to Golgi apparatus; retrograde transport, endosome to Golgi; small GTPase mediated signal transduction; trans-Golgi network" IPR027417; IPR005225; IPR001806; IPR024156; IPR006689; ADP-ribosylation factor-related protein 1 (ARF-related protein 1) ARFRP1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36709_c1_g4_i4 O04267 SAR1B_BRACM 3.00E-19 GO:0005525; GO:0005794; GO:0005783; GO:0006886; GO:0016192 GTP binding; Golgi apparatus; endoplasmic reticulum; intracellular protein transport; vesicle-mediated transport IPR027417; IPR005225; IPR006689; IPR006687; GTP-binding protein SAR1B SAR1B Brassica campestris (Field mustard) TR36710_c0_g1_i2 Q5F2F2 ABH15_MOUSE 4.00E-61 GO:0004091; GO:0005576 carboxylesterase activity; extracellular region IPR012020; Abhydrolase domain-containing protein 15 (EC 3.1.1.-) Abhd15 Mus musculus (Mouse) TR36714_c0_g1_i1 P10746 HEM4_HUMAN 1.00E-36 GO:0071418; GO:0071243; GO:0048037; GO:0005829; GO:0006783; GO:0005739; GO:0006782; GO:0046677; GO:0006780; GO:0004852 cellular response to amine stimulus; cellular response to arsenic-containing substance; cofactor binding; cytosol; heme biosynthetic process; mitochondrion; protoporphyrinogen IX biosynthetic process; response to antibiotic; uroporphyrinogen III biosynthetic process; uroporphyrinogen-III synthase activity IPR003754; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4. Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) UROS Homo sapiens (Human) TR36714_c0_g1_i3 P51163 HEM4_MOUSE 3.00E-38 GO:0005739; GO:0006779; GO:0006782; GO:0006780; GO:0004852 mitochondrion; porphyrin-containing compound biosynthetic process; protoporphyrinogen IX biosynthetic process; uroporphyrinogen III biosynthetic process; uroporphyrinogen-III synthase activity IPR003754; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4. Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) Uros Uros3 Mus musculus (Mouse) TR36714_c0_g1_i4 P51163 HEM4_MOUSE 2.00E-19 GO:0005739; GO:0006779; GO:0006782; GO:0006780; GO:0004852 mitochondrion; porphyrin-containing compound biosynthetic process; protoporphyrinogen IX biosynthetic process; uroporphyrinogen III biosynthetic process; uroporphyrinogen-III synthase activity IPR003754; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4. Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) Uros Uros3 Mus musculus (Mouse) TR36716_c0_g3_i1 P08684 CP3A4_HUMAN 9.00E-126 GO:0047638; GO:0009822; GO:0008209; GO:0034875; GO:0009986; GO:0005789; GO:0042738; GO:0020037; GO:0046483; GO:0016021; GO:0005506; GO:0016098; GO:0070989; GO:0016712; GO:0019825; GO:0050591; GO:0005496; GO:0006706; GO:0033780; GO:0050649; GO:0070576; GO:0030343; GO:0006805 "albendazole monooxygenase activity; alkaloid catabolic process; androgen metabolic process; caffeine oxidase activity; cell surface; endoplasmic reticulum membrane; exogenous drug catabolic process; heme binding; heterocycle metabolic process; integral to membrane; iron ion binding; monoterpenoid metabolic process; oxidative demethylation; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding; quinine 3-monooxygenase activity; steroid binding; steroid catabolic process; taurochenodeoxycholate 6alpha-hydroxylase activity; testosterone 6-beta-hydroxylase activity; vitamin D 24-hydroxylase activity; vitamin D3 25-hydroxylase activity; xenobiotic metabolic process" IPR001128; IPR017972; IPR008072; IPR002402; "Cytochrome P450 3A4 (EC 1.14.13.-) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.13.157) (Albendazole monooxygenase) (EC 1.14.13.32) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.13.67) (Taurochenodeoxycholate 6-alpha-hydroxylase) (EC 1.14.13.97)" CYP3A4 CYP3A3 Homo sapiens (Human) TR36717_c0_g1_i1 Q17778 NUC1_CAEEL 4.00E-56 GO:0006309; GO:0004531; GO:0005764; GO:0005634 apoptotic DNA fragmentation; deoxyribonuclease II activity; lysosome; nucleus IPR004947; Deoxyribonuclease-2 (EC 3.1.22.1) (Deoxyribonuclease II) (DNase II) nuc-1 C07B5.5 Caenorhabditis elegans TR36717_c0_g1_i2 O00115 DNS2A_HUMAN 4.00E-79 GO:0003677; GO:0006308; GO:0006259; GO:0006915; GO:0004531; GO:0030218; GO:0005764 Q9Y265; Q9Y230 DNA binding; DNA catabolic process; DNA metabolic process; apoptotic process; deoxyribonuclease II activity; erythrocyte differentiation; lysosome IPR004947; Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) (R31240_2) DNASE2 DNASE2A DNL2 Homo sapiens (Human) TR36717_c0_g1_i4 Q63IT3 DNS2_BURPS 1.00E-31 GO:0006259; GO:0004531; GO:0090305 DNA metabolic process; deoxyribonuclease II activity; nucleic acid phosphodiester bond hydrolysis IPR004947; Putative deoxyribonuclease-2 (EC 3.1.-.-) (Deoxyribonuclease II) BPSS1983 Burkholderia pseudomallei (strain K96243) TR36717_c0_g1_i5 Q75WF2 DNA2_ACAPL 6.00E-78 GO:0006259; GO:0006915; GO:0004531; GO:0005576; GO:0090305 DNA metabolic process; apoptotic process; deoxyribonuclease II activity; extracellular region; nucleic acid phosphodiester bond hydrolysis IPR004947; Plancitoxin-1 (EC 3.1.22.1) (Plancitoxin I) (Plan-I) [Cleaved into: Plancitoxin-1 subunit alpha; Plancitoxin-1 subunit beta] Acanthaster planci (Crown-of-thorns starfish) TR36717_c0_g1_i7 Q75WF2 DNA2_ACAPL 1.00E-81 GO:0006259; GO:0006915; GO:0004531; GO:0005576; GO:0090305 DNA metabolic process; apoptotic process; deoxyribonuclease II activity; extracellular region; nucleic acid phosphodiester bond hydrolysis IPR004947; Plancitoxin-1 (EC 3.1.22.1) (Plancitoxin I) (Plan-I) [Cleaved into: Plancitoxin-1 subunit alpha; Plancitoxin-1 subunit beta] Acanthaster planci (Crown-of-thorns starfish) TR36720_c0_g1_i2 P62840 UB2D2_XENLA 2.00E-41 GO:0005524; GO:0004842 ATP binding; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 D2 (EC 6.3.2.19) (Ubiquitin carrier protein 4) (xUBC4) (Ubiquitin carrier protein D2) (Ubiquitin-protein ligase D2) ube2d2 ubc4 ube2d3.1 Xenopus laevis (African clawed frog) TR36720_c0_g1_i3 P62840 UB2D2_XENLA 3.00E-41 GO:0005524; GO:0004842 ATP binding; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 D2 (EC 6.3.2.19) (Ubiquitin carrier protein 4) (xUBC4) (Ubiquitin carrier protein D2) (Ubiquitin-protein ligase D2) ube2d2 ubc4 ube2d3.1 Xenopus laevis (African clawed frog) TR36721_c2_g1_i1 Q8IZQ5 SELH_HUMAN 2.00E-19 GO:0045454; GO:0008430 cell redox homeostasis; selenium binding IPR011893; IPR012336; Selenoprotein H (SelH) SELH C11orf31 Homo sapiens (Human) TR36721_c2_g1_i2 Q3UQA7 SELH_MOUSE 9.00E-20 GO:0045454; GO:0008430 cell redox homeostasis; selenium binding IPR011893; IPR012336; Selenoprotein H (SelH) Selh Mus musculus (Mouse) TR36722_c7_g1_i3 P55859 PNPH_BOVIN 8.00E-97 GO:0005737; GO:0005856; GO:0009116; GO:0004731 cytoplasm; cytoskeleton; nucleoside metabolic process; purine-nucleoside phosphorylase activity IPR000845; IPR001369; IPR011270; IPR011268; IPR018099; Purine metabolism; purine nucleoside salvage. Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) PNP NP Bos taurus (Bovine) TR36723_c5_g2_i1 Q9UGU0 TCF20_HUMAN 3.00E-25 GO:0003677; GO:0005634; GO:0006355; GO:0003713; GO:0006351; GO:0008270 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent; zinc ion binding" IPR001965; Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) TCF20 KIAA0292 SPBP Homo sapiens (Human) TR36724_c0_g1_i1 O14735 CDIPT_HUMAN 2.00E-75 GO:0046341; GO:0003881; GO:0000139; GO:0043178; GO:0030246; GO:0019992; GO:0005789; GO:0016021; GO:0030145; GO:0006661; GO:0005886; GO:0044281 CDP-diacylglycerol metabolic process; CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity; Golgi membrane; alcohol binding; carbohydrate binding; diacylglycerol binding; endoplasmic reticulum membrane; integral to membrane; manganese ion binding; phosphatidylinositol biosynthetic process; plasma membrane; small molecule metabolic process IPR000462; IPR014387; CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase) CDIPT PIS PIS1 Homo sapiens (Human) TR36724_c0_g1_i2 Q8GUK6 PIS2_ARATH 1.00E-26 GO:0003881; GO:0005794; GO:0005783; GO:0016021; GO:0046872; GO:0008654 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity; Golgi apparatus; endoplasmic reticulum; integral to membrane; metal ion binding; phospholipid biosynthetic process IPR000462; IPR014387; Probable CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2 (EC 2.7.8.11) (Phosphatidylinositol synthase 2) (AtPIS2) (PI synthase 2) (PtdIns synthase 2) PIS2 At4g38570 F20M13.130 Arabidopsis thaliana (Mouse-ear cress) TR36725_c2_g1_i12 Q8N1A6 CD033_HUMAN 2.00E-56 UPF0462 protein C4orf33 C4orf33 Homo sapiens (Human) TR36725_c2_g1_i5 Q28GP0 CD033_XENTR 6.00E-49 UPF0462 protein C4orf33 homolog TEgg072n04.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36725_c2_g1_i9 Q8N1A6 CD033_HUMAN 1.00E-59 UPF0462 protein C4orf33 C4orf33 Homo sapiens (Human) TR36726_c6_g1_i1 Q55E58 PATS1_DICDI 2.00E-06 GO:0005524; GO:0005525; GO:0042641; GO:0000281; GO:0004721; GO:0006470; GO:0004674; GO:0007264 ATP binding; GTP binding; actomyosin; mitotic cytokinesis; phosphoprotein phosphatase activity; protein dephosphorylation; protein serine/threonine kinase activity; small GTPase mediated signal transduction IPR011009; IPR001611; IPR013684; IPR010569; IPR017906; IPR027417; IPR000719; IPR011047; IPR020859; IPR001245; IPR008271; IPR005225; IPR001806; IPR015943; IPR001680; IPR017986; Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) TR36727_c2_g1_i1 Q4R4U1 PANK4_MACFA 0 GO:0005524; GO:0015937; GO:0005737; GO:0004594 ATP binding; coenzyme A biosynthetic process; cytoplasm; pantothenate kinase activity IPR002791; IPR015844; IPR004567; Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Pantothenate kinase 4 (EC 2.7.1.33) (Pantothenic acid kinase 4) PANK4 QccE-17245 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR36727_c2_g2_i1 O80765 PANK1_ARATH 8.00E-63 GO:0005524; GO:0015937; GO:0004594 ATP binding; coenzyme A biosynthetic process; pantothenate kinase activity IPR004567; Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Pantothenate kinase 1 (EC 2.7.1.33) (Pantothenic acid kinase 1) (AtCoaA) COAA At1g60440 T13D8.31 Arabidopsis thaliana (Mouse-ear cress) TR36729_c0_g1_i1 Q64121 PRLHR_RAT 3.00E-07 GO:0004930; GO:0007631; GO:0016021; GO:0004983; GO:0017046; GO:0005886 G-protein coupled receptor activity; feeding behavior; integral to membrane; neuropeptide Y receptor activity; peptide hormone binding; plasma membrane IPR000276; IPR017452; IPR001402; Prolactin-releasing peptide receptor (PrRP receptor) (PrRPR) (G-protein coupled receptor 10) (UHR-1) Prlhr Gpr10 Rattus norvegicus (Rat) TR36729_c0_g1_i3 P79266 GASR_BOVIN 1.00E-10 GO:0048565; GO:0007204; GO:0001696; GO:0015054; GO:0048732; GO:0016021; GO:0005886; GO:0008284 digestive tract development; elevation of cytosolic calcium ion concentration; gastric acid secretion; gastrin receptor activity; gland development; integral to membrane; plasma membrane; positive regulation of cell proliferation IPR009126; IPR000314; IPR000276; IPR017452; Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R) CCKBR Bos taurus (Bovine) TR36729_c0_g1_i4 Q64121 PRLHR_RAT 3.00E-07 GO:0004930; GO:0007631; GO:0016021; GO:0004983; GO:0017046; GO:0005886 G-protein coupled receptor activity; feeding behavior; integral to membrane; neuropeptide Y receptor activity; peptide hormone binding; plasma membrane IPR000276; IPR017452; IPR001402; Prolactin-releasing peptide receptor (PrRP receptor) (PrRPR) (G-protein coupled receptor 10) (UHR-1) Prlhr Gpr10 Rattus norvegicus (Rat) TR36729_c0_g1_i5 P30994 5HT2B_RAT 8.00E-06 GO:0070371; GO:0001965; GO:0002031; GO:0005099; GO:0007610; GO:0006182; GO:0005262; GO:0019722; GO:0003300; GO:0030054; GO:0071502; GO:0005737; GO:0008144; GO:0048598; GO:0003007; GO:0005887; GO:0014827; GO:0043066; GO:0010507; GO:0001755; GO:0043005; GO:0014065; GO:0004435; GO:0016310; GO:0005886; GO:0070374; GO:0043123; GO:0051781; GO:0001819; GO:0050715; GO:0001938; GO:0051000; GO:0010513; GO:0070528; GO:0007205; GO:0050795; GO:0051209; GO:0042493; GO:0051378; GO:0004993; GO:0045202; GO:0042310 ERK1 and ERK2 cascade; G-protein alpha-subunit binding; G-protein coupled receptor internalization; Ras GTPase activator activity; behavior; cGMP biosynthetic process; calcium channel activity; calcium-mediated signaling; cardiac muscle hypertrophy; cell junction; cellular response to temperature stimulus; cytoplasm; drug binding; embryonic morphogenesis; heart morphogenesis; integral to plasma membrane; intestine smooth muscle contraction; negative regulation of apoptotic process; negative regulation of autophagy; neural crest cell migration; neuron projection; phosphatidylinositol 3-kinase cascade; phosphatidylinositol phospholipase C activity; phosphorylation; plasma membrane; positive regulation of ERK1 and ERK2 cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of cell division; positive regulation of cytokine production; positive regulation of cytokine secretion; positive regulation of endothelial cell proliferation; positive regulation of nitric-oxide synthase activity; positive regulation of phosphatidylinositol biosynthetic process; protein kinase C signaling cascade; protein kinase C-activating G-protein coupled receptor signaling pathway; regulation of behavior; release of sequestered calcium ion into cytosol; response to drug; serotonin binding; serotonin receptor activity; synapse; vasoconstriction IPR000482; IPR002231; IPR000276; IPR017452; 5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (5-HT-2F) (Serotonin receptor 2B) (Stomach fundus serotonin receptor) Htr2b Srl Rattus norvegicus (Rat) TR36729_c0_g1_i6 P79266 GASR_BOVIN 1.00E-10 GO:0048565; GO:0007204; GO:0001696; GO:0015054; GO:0048732; GO:0016021; GO:0005886; GO:0008284 digestive tract development; elevation of cytosolic calcium ion concentration; gastric acid secretion; gastrin receptor activity; gland development; integral to membrane; plasma membrane; positive regulation of cell proliferation IPR009126; IPR000314; IPR000276; IPR017452; Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R) CCKBR Bos taurus (Bovine) TR36729_c0_g1_i7 Q99677 LPAR4_HUMAN 4.00E-07 GO:0004930; GO:0005887; GO:0008289 G-protein coupled receptor activity; integral to plasma membrane; lipid binding IPR000276; IPR017452; Lysophosphatidic acid receptor 4 (LPA receptor 4) (LPA-4) (G-protein coupled receptor 23) (P2Y purinoceptor 9) (P2Y9) (P2Y5-like receptor) (Purinergic receptor 9) LPAR4 GPR23 LPA4 P2RY9 Homo sapiens (Human) TR36731_c0_g1_i1 Q15750 TAB1_HUMAN 3.00E-112 GO:0038095; GO:0007249; GO:0007254; GO:0002755; GO:0035666; GO:0000187; GO:0000185; GO:0003824; GO:0005829; GO:0010008; GO:0008047; GO:0003007; GO:0001701; GO:0045087; GO:0019209; GO:0030324; GO:0008152; GO:0070423; GO:0051092; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124; GO:0007179 Q9NYJ8 Fc-epsilon receptor signaling pathway; I-kappaB kinase/NF-kappaB cascade; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; activation of MAPK activity; activation of MAPKKK activity; catalytic activity; cytosol; endosome membrane; enzyme activator activity; heart morphogenesis; in utero embryonic development; innate immune response; kinase activator activity; lung development; metabolic process; nucleotide-binding oligomerization domain containing signaling pathway; positive regulation of NF-kappaB transcription factor activity; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor TLR1:TLR2 signaling pathway; toll-like receptor TLR6:TLR2 signaling pathway; transforming growth factor beta receptor signaling pathway IPR001932; IPR015655; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) TAB1 MAP3K7IP1 Homo sapiens (Human) TR36731_c0_g1_i2 Q15750 TAB1_HUMAN 3.00E-112 GO:0038095; GO:0007249; GO:0007254; GO:0002755; GO:0035666; GO:0000187; GO:0000185; GO:0003824; GO:0005829; GO:0010008; GO:0008047; GO:0003007; GO:0001701; GO:0045087; GO:0019209; GO:0030324; GO:0008152; GO:0070423; GO:0051092; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124; GO:0007179 Q9NYJ8 Fc-epsilon receptor signaling pathway; I-kappaB kinase/NF-kappaB cascade; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; activation of MAPK activity; activation of MAPKKK activity; catalytic activity; cytosol; endosome membrane; enzyme activator activity; heart morphogenesis; in utero embryonic development; innate immune response; kinase activator activity; lung development; metabolic process; nucleotide-binding oligomerization domain containing signaling pathway; positive regulation of NF-kappaB transcription factor activity; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor TLR1:TLR2 signaling pathway; toll-like receptor TLR6:TLR2 signaling pathway; transforming growth factor beta receptor signaling pathway IPR001932; IPR015655; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) TAB1 MAP3K7IP1 Homo sapiens (Human) TR36731_c0_g1_i3 A0DTY1 PP2C4_PARTE 5.00E-16 GO:0016020; GO:0046872; GO:0006470; GO:0004722 membrane; metal ion binding; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; Probable protein phosphatase 2C 4 (PP2C 4) (EC 3.1.3.16) GSPATT00020181001 Paramecium tetraurelia TR36732_c3_g1_i1 Q8QGW7 LITAF_CHICK 1.00E-18 GO:0005125; GO:0005737; GO:0006355; GO:0006351 "cytokine activity; cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) TR36732_c3_g1_i2 Q8QGW7 LITAF_CHICK 4.00E-18 GO:0005125; GO:0005737; GO:0006355; GO:0006351 "cytokine activity; cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) TR36733_c3_g1_i1 O75791 GRAP2_HUMAN 1.00E-38 GO:0038095; GO:0007265; GO:0005070; GO:0031295; GO:0050852; GO:0007267; GO:0005829; GO:0005768; GO:0045087; GO:0005634 Q08460; Q13094; Q9H3S7 Fc-epsilon receptor signaling pathway; Ras protein signal transduction; SH3/SH2 adaptor activity; T cell costimulation; T cell receptor signaling pathway; cell-cell signaling; cytosol; endosome; innate immune response; nucleus IPR000980; IPR001452; GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona) GRAP2 GADS GRB2L GRID Homo sapiens (Human) TR36733_c3_g1_i3 Q6YKA8 DRK_DROSI 1.00E-77 GO:0005070; GO:0005886; GO:0004871 SH3/SH2 adaptor activity; plasma membrane; signal transducer activity IPR000108; IPR000980; IPR001452; Protein E(sev)2B (Downstream of receptor kinase) (Protein enhancer of sevenless 2B) (SH2-SH3 adapter protein drk) drk E(sev)2B Drosophila simulans (Fruit fly) TR36733_c3_g1_i4 Q60631 GRB2_MOUSE 9.00E-16 GO:0008180; GO:0005794; GO:0070436; GO:0007265; GO:0017124; GO:0005070; GO:0007568; GO:0048646; GO:0060670; GO:0030154; GO:0071479; GO:0005829; GO:0005768; GO:0008286; GO:0005886; GO:0030838; GO:2000379; GO:0051291; GO:0031623; GO:0043408; GO:0042770; GO:0012506 O54737; P35991; B9EKI5; P35329; P98078; Q99JZ7; Q8C180; Q9QYY0; Q52KG5; O54957; Q62077; P04925; P18052; Q91ZZ2; P98083; Q62245; Q02384; Q02858; Q99PM9 COP9 signalosome; Golgi apparatus; Grb2-EGFR complex; Ras protein signal transduction; SH3 domain binding; SH3/SH2 adaptor activity; aging; anatomical structure formation involved in morphogenesis; branching involved in labyrinthine layer morphogenesis; cell differentiation; cellular response to ionizing radiation; cytosol; endosome; insulin receptor signaling pathway; plasma membrane; positive regulation of actin filament polymerization; positive regulation of reactive oxygen species metabolic process; protein heterooligomerization; receptor internalization; regulation of MAPK cascade; signal transduction in response to DNA damage; vesicle membrane IPR000108; IPR000980; IPR001452; Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) Grb2 Mus musculus (Mouse) TR36736_c0_g1_i1 Q4G061 EIF3B_RAT 0 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0000166; GO:0006446; GO:0003743; GO:0006413 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; nucleotide binding; regulation of translational initiation; translation initiation factor activity; translational initiation IPR011042; IPR011400; IPR012677; IPR000504; IPR013979; IPR015943; Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (eIF-3-eta) Eif3b Eif3s9 Rattus norvegicus (Rat) TR36736_c0_g1_i2 Q8JZQ9 EIF3B_MOUSE 0 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0000166; GO:0006446; GO:0003743; GO:0006413 Q6NZJ6 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; nucleotide binding; regulation of translational initiation; translation initiation factor activity; translational initiation IPR011042; IPR011400; IPR012677; IPR000504; IPR013979; IPR015943; Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (eIF-3-eta) (eIF3 p116) Eif3b Eif3s9 Mus musculus (Mouse) TR36737_c0_g1_i1 O94889 KLH18_HUMAN 4.00E-52 IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 18 KLHL18 KIAA0795 OK/SW-cl.74 Homo sapiens (Human) TR36737_c0_g1_i2 Q56A24 KLH24_RAT 2.00E-67 GO:0030424; GO:0005737; GO:0043204 axon; cytoplasm; perikaryon IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) Klhl24 Dre1 Rattus norvegicus (Rat) TR36740_c0_g1_i1 Q6TUG0 DJB11_RAT 6.00E-133 GO:0005788; GO:0016556; GO:0005634; GO:0006457 endoplasmic reticulum lumen; mRNA modification; nucleus; protein folding IPR002939; IPR001623; IPR018253; IPR008971; DnaJ homolog subfamily B member 11 (ER-associated DNAJ) (ER-associated Hsp40 co-chaperone) (Endoplasmic reticulum DNA J domain-containing protein 3) (ER-resident protein ERdj3) (ERdj3) (ERj3p) (Liver regeneration-related protein LRRGT00084) Dnajb11 Rattus norvegicus (Rat) TR36740_c0_g1_i4 Q8MPX3 DNJ20_CAEEL 6.00E-113 GO:0006457 protein folding IPR002939; IPR001623; IPR018253; IPR008971; DnaJ homolog dnj-20 (DnaJ domain protein 20) dnj-20 T15H9.7/T15H9.1 Caenorhabditis elegans TR36741_c4_g1_i1 Q8NF91 SYNE1_HUMAN 2.00E-148 GO:0005794; GO:0007030; GO:0034993; GO:0003779; GO:0008219; GO:0090286; GO:0005856; GO:0016021; GO:0042692; GO:0090292; GO:0031965; GO:0005640; GO:0045211; GO:0042803; GO:0030017 Q9NRI5; O94901; Q9UH99 Golgi apparatus; Golgi organization; SUN-KASH complex; actin binding; cell death; cytoskeletal anchoring at nuclear membrane; cytoskeleton; integral to membrane; muscle cell differentiation; nuclear matrix anchoring at nuclear membrane; nuclear membrane; nuclear outer membrane; postsynaptic membrane; protein homodimerization activity; sarcomere IPR001589; IPR001715; IPR012315; IPR018159; IPR002017; Nesprin-1 (Enaptin) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) SYNE1 C6orf98 KIAA0796 KIAA1262 KIAA1756 MYNE1 Homo sapiens (Human) TR36744_c0_g2_i2 P81600 ADHH_GADMO 6.00E-159 GO:0051903; GO:0004022; GO:0005737; GO:0006069; GO:0008270 S-(hydroxymethyl)glutathione dehydrogenase activity; alcohol dehydrogenase (NAD) activity; cytoplasm; ethanol oxidation; zinc ion binding IPR014183; IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; Alcohol dehydrogenase class-3 chain H (EC 1.1.1.1) (Alcohol dehydrogenase class-III chain H) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) Gadus morhua (Atlantic cod) TR36744_c0_g2_i3 Q763T4 LAD_ASPOZ 1.00E-08 GO:0050019; GO:0019569; GO:0000166; GO:0008270 L-arabinitol 4-dehydrogenase activity; L-arabinose catabolic process to xylulose 5-phosphate; nucleotide binding; zinc ion binding IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5. L-arabinitol 4-dehydrogenase (LAD) (EC 1.1.1.12) ladA xdhB Aspergillus oryzae (Yellow koji mold) TR36745_c3_g2_i1 Q70E20 SNED1_MOUSE 4.00E-15 GO:0005509; GO:0007160; GO:0005576 calcium ion binding; cell-matrix adhesion; extracellular region IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003961; IPR009030; IPR013783; IPR003886; IPR000436; "Sushi, nidogen and EGF-like domain-containing protein 1 (Secreted protein SST-3) (Stromal nidogen extracellular matrix protein)" Sned1 Snep Mus musculus (Mouse) TR36745_c3_g3_i1 Q9VW71 FAT2_DROME 1.00E-06 GO:0009925; GO:0005509; GO:0016339; GO:0050839; GO:0050829; GO:0042247; GO:0030950; GO:0005925; GO:0007440; GO:0007295; GO:0007442; GO:0007156; GO:0005887; GO:0045571; GO:0007424; GO:0045089; GO:0004872; GO:0007431 basal plasma membrane; calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; defense response to Gram-negative bacterium; establishment of planar polarity of follicular epithelium; establishment or maintenance of actin cytoskeleton polarity; focal adhesion; foregut morphogenesis; growth of a germarium-derived egg chamber; hindgut morphogenesis; homophilic cell adhesion; integral to plasma membrane; negative regulation of imaginal disc growth; open tracheal system development; positive regulation of innate immune response; receptor activity; salivary gland development IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Fat-like cadherin-related tumor suppressor homolog (Protein kugelei) kug fat2 CG7749 Drosophila melanogaster (Fruit fly) TR36745_c3_g4_i1 Q4LDE5 SVEP1_HUMAN 1.00E-08 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) TR36745_c4_g1_i1 Q8R054 SRPX2_MOUSE 3.00E-11 GO:0001525; GO:0048870; GO:0016337; GO:0005737; GO:0005576; GO:0015630; GO:0090050; GO:0042325 angiogenesis; cell motility; cell-cell adhesion; cytoplasm; extracellular region; microtubule cytoskeleton; positive regulation of cell migration involved in sprouting angiogenesis; regulation of phosphorylation IPR025232; IPR003410; IPR000436; Sushi repeat-containing protein SRPX2 Srpx2 Mus musculus (Mouse) TR36746_c3_g1_i1 Q28FF3 MFS7A_XENTR 6.00E-103 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Major facilitator superfamily domain-containing protein 7-a mfsd7-A TEgg026p17.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36747_c0_g1_i1 Q60803 TRAF3_MOUSE 3.00E-25 GO:0035631; GO:0008063; GO:0006915; GO:0005768; GO:0045087; GO:0009898; GO:0032088; GO:0042981; GO:0050688; GO:0032648; GO:0030162; GO:0002224; GO:0033209; GO:0004842; GO:0008270 Q8VCF0; O35305; P47741; P39429 CD40 receptor complex; Toll signaling pathway; apoptotic process; endosome; innate immune response; internal side of plasma membrane; negative regulation of NF-kappaB transcription factor activity; regulation of apoptotic process; regulation of defense response to virus; regulation of interferon-beta production; regulation of proteolysis; toll-like receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR013323; IPR012227; IPR008974; IPR027128; IPR001841; IPR013083; IPR017907; IPR001293; TNF receptor-associated factor 3 (EC 6.3.2.-) (CD40 receptor-associated factor 1) (CRAF1) (TRAFAMN) Traf3 Craf1 Trafamn Mus musculus (Mouse) TR36747_c0_g1_i6 Q86L54 Y2829_DICDI 7.00E-08 GO:0005737; GO:0004842; GO:0008270 cytoplasm; ubiquitin-protein ligase activity; zinc ion binding IPR013323; IPR008974; IPR015880; IPR001841; IPR013083; IPR001293; TNF receptor-associated factor family protein DDB_G0272829 DDB_G0272829 Dictyostelium discoideum (Slime mold) TR36752_c0_g1_i1 Q3ZCD7 TECR_BOVIN 2.00E-107 GO:0030497; GO:0030176; GO:0016627; GO:0006694; GO:0042761 "fatty acid elongation; integral to endoplasmic reticulum membrane; oxidoreductase activity, acting on the CH-CH group of donors; steroid biosynthetic process; very long-chain fatty acid biosynthetic process" IPR001104; "Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER)" TECR GPSN2 Bos taurus (Bovine) TR36752_c0_g1_i2 Q3ZCD7 TECR_BOVIN 4.00E-126 GO:0030497; GO:0030176; GO:0016627; GO:0006694; GO:0042761 "fatty acid elongation; integral to endoplasmic reticulum membrane; oxidoreductase activity, acting on the CH-CH group of donors; steroid biosynthetic process; very long-chain fatty acid biosynthetic process" IPR001104; "Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER)" TECR GPSN2 Bos taurus (Bovine) TR36752_c0_g1_i3 O94511 YN67_SCHPO 2.00E-49 GO:0005789; GO:0016631; GO:0030497; GO:0016021; GO:0005739; GO:0019166; GO:0000038 endoplasmic reticulum membrane; enoyl-[acyl-carrier-protein] reductase activity; fatty acid elongation; integral to membrane; mitochondrion; trans-2-enoyl-CoA reductase (NADPH) activity; very long-chain fatty acid metabolic process IPR001104; IPR000626; Putative enoyl reductase C646.07c (EC 1.3.1.38) SPBC646.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36753_c0_g1_i1 Q5XHC1 CD047_XENLA 6.00E-85 UPF0602 protein C4orf47 homolog Xenopus laevis (African clawed frog) TR36758_c1_g3_i1 Q15428 SF3A2_HUMAN 4.00E-56 GO:0071013; GO:0000389; GO:0003676; GO:0005654; GO:0030532; GO:0008270 Q99459; Q15459 catalytic step 2 spliceosome; mRNA 3'-splice site recognition; nucleic acid binding; nucleoplasm; small nuclear ribonucleoprotein complex; zinc ion binding IPR019134; IPR015880; IPR000690; IPR003604; Splicing factor 3A subunit 2 (SF3a66) (Spliceosome-associated protein 62) (SAP 62) SF3A2 SAP62 Homo sapiens (Human) TR36759_c0_g1_i2 Q00748 MDR65_DROME 6.00E-06 GO:0005524; GO:0043190; GO:0015562; GO:0060857; GO:0016021; GO:0005886; GO:0005919; GO:0031427; GO:0008559 ATP binding; ATP-binding cassette (ABC) transporter complex; efflux transmembrane transporter activity; establishment of glial blood-brain barrier; integral to membrane; plasma membrane; pleated septate junction; response to methotrexate; xenobiotic-transporting ATPase activity IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance protein homolog 65 (EC 3.6.3.44) (P-glycoprotein 65) Mdr65 CG10181 Drosophila melanogaster (Fruit fly) TR36760_c0_g1_i2 Q4PBE6 HAT1_USTMA 2.00E-62 GO:0006281; GO:0006348; GO:0005737; GO:0004402; GO:0000123 DNA repair; chromatin silencing at telomere; cytoplasm; histone acetyltransferase activity; histone acetyltransferase complex IPR016181; IPR019467; IPR017380; IPR013523; Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) HAT1 UM02567 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR36760_c0_g1_i3 O14929 HAT1_HUMAN 3.00E-133 GO:0006323; GO:0006348; GO:0005737; GO:0004402; GO:0016363; GO:0005654; GO:0005634; GO:0007584 P62805; P12520 DNA packaging; chromatin silencing at telomere; cytoplasm; histone acetyltransferase activity; nuclear matrix; nucleoplasm; nucleus; response to nutrient IPR016181; IPR019467; IPR017380; Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1) HAT1 KAT1 Homo sapiens (Human) TR36761_c3_g1_i1 P51644 ARF4_XENLA 4.00E-102 GO:0005525; GO:0005794; GO:0015031; GO:0007264; GO:0016192 P29403 GTP binding; Golgi apparatus; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor 4 arf4 Xenopus laevis (African clawed frog) TR36761_c3_g1_i2 P51644 ARF4_XENLA 3.00E-102 GO:0005525; GO:0005794; GO:0015031; GO:0007264; GO:0016192 P29403 GTP binding; Golgi apparatus; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor 4 arf4 Xenopus laevis (African clawed frog) TR36766_c0_g2_i1 Q5RBU7 PCP_PONAB 0 GO:0004180; GO:0005764; GO:0006508; GO:0008236 carboxypeptidase activity; lysosome; proteolysis; serine-type peptidase activity IPR008758; Lysosomal Pro-X carboxypeptidase (EC 3.4.16.2) (Proline carboxypeptidase) (Prolylcarboxypeptidase) (PRCP) PRCP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36769_c2_g1_i1 P49755 TMEDA_HUMAN 8.00E-85 GO:0048205; GO:0030137; GO:0048208; GO:0007030; GO:0034205; GO:0035459; GO:0005801; GO:0005783; GO:0005789; GO:0005793; GO:0033116; GO:0070765; GO:0016021; GO:0006886; GO:0001822; GO:0042470; GO:0051259; GO:0045055; GO:0001101; GO:0043279; GO:0006890; GO:0030140; GO:0030658; GO:0042589 Q92542; P49768; Q9NZ42; P17706-1; Q15363 "COPI coating of Golgi vesicle; COPI-coated vesicle; COPII vesicle coating; Golgi organization; beta-amyloid formation; cargo loading into vesicle; cis-Golgi network; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; gamma-secretase complex; integral to membrane; intracellular protein transport; kidney development; melanosome; protein oligomerization; regulated secretory pathway; response to acid; response to alkaloid; retrograde vesicle-mediated transport, Golgi to ER; trans-Golgi network transport vesicle; transport vesicle membrane; zymogen granule membrane" IPR009038; Transmembrane emp24 domain-containing protein 10 (21 kDa transmembrane-trafficking protein) (S31III125) (S31I125) (Tmp-21-I) (Transmembrane protein Tmp21) (p23) (p24 family protein delta-1) (p24delta1) (p24delta) TMED10 TMP21 Homo sapiens (Human) TR36769_c2_g1_i2 B4MGF8 TMEDA_DROVI 7.00E-80 GO:0009953; GO:0016021; GO:0006810 dorsal/ventral pattern formation; integral to membrane; transport IPR009038; Transmembrane emp24 domain-containing protein bai bai GJ14134 Drosophila virilis (Fruit fly) TR36769_c2_g1_i4 P49755 TMEDA_HUMAN 5.00E-86 GO:0048205; GO:0030137; GO:0048208; GO:0007030; GO:0034205; GO:0035459; GO:0005801; GO:0005783; GO:0005789; GO:0005793; GO:0033116; GO:0070765; GO:0016021; GO:0006886; GO:0001822; GO:0042470; GO:0051259; GO:0045055; GO:0001101; GO:0043279; GO:0006890; GO:0030140; GO:0030658; GO:0042589 Q92542; P49768; Q9NZ42; P17706-1; Q15363 "COPI coating of Golgi vesicle; COPI-coated vesicle; COPII vesicle coating; Golgi organization; beta-amyloid formation; cargo loading into vesicle; cis-Golgi network; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; gamma-secretase complex; integral to membrane; intracellular protein transport; kidney development; melanosome; protein oligomerization; regulated secretory pathway; response to acid; response to alkaloid; retrograde vesicle-mediated transport, Golgi to ER; trans-Golgi network transport vesicle; transport vesicle membrane; zymogen granule membrane" IPR009038; Transmembrane emp24 domain-containing protein 10 (21 kDa transmembrane-trafficking protein) (S31III125) (S31I125) (Tmp-21-I) (Transmembrane protein Tmp21) (p23) (p24 family protein delta-1) (p24delta1) (p24delta) TMED10 TMP21 Homo sapiens (Human) TR36770_c2_g1_i1 Q0VAW7 ZF112_MOUSE 2.00E-60 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 112 (Zfp-112) Znf112 Zfp112 Mus musculus (Mouse) TR36770_c3_g3_i1 Q25C93 FEZF1_DANRE 6.00E-23 GO:0003677; GO:0030154; GO:0046872; GO:0007399; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cell differentiation; metal ion binding; nervous system development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Fez family zinc finger protein 1 fezf1 fez Danio rerio (Zebrafish) (Brachydanio rerio) TR36771_c0_g1_i2 Q9D1L0 CHCH2_MOUSE 7.00E-13 GO:0005739 mitochondrion IPR010625; "Coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial" Chchd2 Mus musculus (Mouse) TR36771_c0_g1_i4 Q9D1L0 CHCH2_MOUSE 1.00E-12 GO:0005739 mitochondrion IPR010625; "Coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial" Chchd2 Mus musculus (Mouse) TR36772_c0_g1_i1 Q8BJI1 S6A17_MOUSE 8.00E-39 GO:0032328; GO:0030054; GO:0015816; GO:0005887; GO:0015820; GO:0005328; GO:0015824; GO:0008021; GO:0030672 alanine transport; cell junction; glycine transport; integral to plasma membrane; leucine transport; neurotransmitter:sodium symporter activity; proline transport; synaptic vesicle; synaptic vesicle membrane IPR000175; IPR002438; Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17) Slc6a17 Ntt4 Mus musculus (Mouse) TR36772_c0_g1_i3 P45320 Y1690_HAEIN 4.00E-12 GO:0016021; GO:0005328; GO:0005886 integral to membrane; neurotransmitter:sodium symporter activity; plasma membrane IPR000175; Uncharacterized sodium-dependent transporter HI_1690 HI_1690 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) TR36772_c0_g2_i1 Q761V0 SC6A5_MOUSE 6.00E-108 GO:0016021; GO:0005328 integral to membrane; neurotransmitter:sodium symporter activity IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) Slc6a5 Glyt2 Mus musculus (Mouse) TR36773_c0_g1_i1 P10155 RO60_HUMAN 9.00E-106 GO:0003723; GO:0060271; GO:0005737; GO:0046872; GO:0005634; GO:0030529; GO:0006383 Q9UHX1 RNA binding; cilium morphogenesis; cytoplasm; metal ion binding; nucleus; ribonucleoprotein complex; transcription from RNA polymerase III promoter IPR008858; IPR018698; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) TR36774_c2_g2_i2 P27169 PON1_HUMAN 6.00E-57 GO:0019439; GO:0004063; GO:0004064; GO:0005509; GO:0046395; GO:0008203; GO:0043231; GO:0046434; GO:0046470; GO:0005543; GO:0051099; GO:0010875; GO:0032411; GO:0042803; GO:0009605; GO:0009636; GO:0034366 aromatic compound catabolic process; aryldialkylphosphatase activity; arylesterase activity; calcium ion binding; carboxylic acid catabolic process; cholesterol metabolic process; intracellular membrane-bounded organelle; organophosphate catabolic process; phosphatidylcholine metabolic process; phospholipid binding; positive regulation of binding; positive regulation of cholesterol efflux; positive regulation of transporter activity; protein homodimerization activity; response to external stimulus; response to toxic substance; spherical high-density lipoprotein particle IPR011042; IPR002640; IPR008363; Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1) PON1 PON Homo sapiens (Human) TR36774_c3_g1_i1 Q14CX7 NAA25_HUMAN 2.00E-141 GO:0005737 P24941 cytoplasm IPR019183; IPR013026; IPR011990; "N-alpha-acetyltransferase 25, NatB auxiliary subunit (Mitochondrial distribution and morphology protein 20) (N-terminal acetyltransferase B complex subunit MDM20) (NatB complex subunit MDM20) (N-terminal acetyltransferase B complex subunit NAA25) (p120)" NAA25 C12orf30 MDM20 NAP1 Homo sapiens (Human) TR36774_c3_g3_i1 Q6QI44 NAA25_RAT 4.00E-69 GO:0005737 cytoplasm IPR019183; IPR013026; IPR011990; "N-alpha-acetyltransferase 25, NatB auxiliary subunit (Liver regeneration-related protein LRRGT00164) (Mitochondrial distribution and morphology protein 20) (N-terminal acetyltransferase B complex subunit MDM20) (NatB complex subunit MDM20) (N-terminal acetyltransferase B complex subunit NAA25)" Naa25 Mdm20 Rattus norvegicus (Rat) TR36774_c4_g1_i1 P27170 PON1_RABIT 3.00E-10 GO:0016209; GO:0004063; GO:0004064; GO:0005509; GO:0005576; GO:0034364; GO:0046683 antioxidant activity; aryldialkylphosphatase activity; arylesterase activity; calcium ion binding; extracellular region; high-density lipoprotein particle; response to organophosphorus IPR011042; IPR002640; IPR008363; Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (Serum aryldialkylphosphatase 1) PON1 PON Oryctolagus cuniculus (Rabbit) TR36775_c7_g1_i1 Q7TNC4 LC7L2_MOUSE 9.00E-31 GO:0005685; GO:0003729; GO:0006376; GO:0016607 U1 snRNP; mRNA binding; mRNA splice site selection; nuclear speck IPR004882; Putative RNA-binding protein Luc7-like 2 (CGI-74 homolog) Luc7l2 Mus musculus (Mouse) TR36775_c7_g1_i2 Q09217 YP68_CAEEL 2.00E-12 GO:0005685; GO:0003729; GO:0006376 U1 snRNP; mRNA binding; mRNA splice site selection IPR004882; Uncharacterized protein B0495.8 B0495.8 Caenorhabditis elegans TR36775_c7_g1_i3 Q5R8W6 LC7L3_PONAB 2.00E-89 GO:0003677; GO:0008380; GO:0005685; GO:0003729; GO:0006376; GO:0016607; GO:0005634 DNA binding; RNA splicing; U1 snRNP; mRNA binding; mRNA splice site selection; nuclear speck; nucleus IPR004882; Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) LUC7L3 CROP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36775_c7_g1_i4 Q3SX41 LC7L3_BOVIN 2.00E-25 GO:0003677; GO:0008380; GO:0005685; GO:0005925; GO:0003729; GO:0006376; GO:0016607; GO:0005634; GO:0005886 DNA binding; RNA splicing; U1 snRNP; focal adhesion; mRNA binding; mRNA splice site selection; nuclear speck; nucleus; plasma membrane IPR004882; Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) LUC7L3 CROP Bos taurus (Bovine) TR36777_c1_g1_i1 Q4PLW0 PLIN2_PIG 2.00E-44 GO:0016020 membrane IPR004279; Perilipin-2 (Adipophilin) (Adipose differentiation-related protein) (ADRP) PLIN2 ADFP ADRP Sus scrofa (Pig) TR36778_c0_g1_i1 Q9DAZ9 ZFY19_MOUSE 3.00E-29 GO:0008270 zinc ion binding IPR000306; IPR017455; IPR011011; IPR001841; IPR013083; Zinc finger FYVE domain-containing protein 19 Zfyve19 Mus musculus (Mouse) TR36778_c0_g1_i4 Q9DAZ9 ZFY19_MOUSE 1.00E-27 GO:0008270 zinc ion binding IPR000306; IPR017455; IPR011011; IPR001841; IPR013083; Zinc finger FYVE domain-containing protein 19 Zfyve19 Mus musculus (Mouse) TR36778_c0_g1_i7 Q8K296 MTMR3_MOUSE 9.00E-07 GO:0046872; GO:0035335; GO:0046856; GO:0004438; GO:0004725 metal ion binding; peptidyl-tyrosine dephosphorylation; phosphatidylinositol dephosphorylation; phosphatidylinositol-3-phosphatase activity; protein tyrosine phosphatase activity IPR010569; IPR017906; IPR016130; IPR000306; IPR017455; IPR011011; IPR013083; Myotubularin-related protein 3 (EC 3.1.3.48) Mtmr3 Mus musculus (Mouse) TR36779_c0_g2_i2 Q0P570 MVD1_BOVIN 8.00E-144 GO:0005524; GO:0030544; GO:0006695; GO:0005829; GO:0004163; GO:0008299; GO:0008284; GO:0042803 ATP binding; Hsp70 protein binding; cholesterol biosynthetic process; cytosol; diphosphomevalonate decarboxylase activity; isoprenoid biosynthetic process; positive regulation of cell proliferation; protein homodimerization activity IPR006204; IPR005935; IPR020568; IPR014721; Steroid biosynthesis; cholesterol biosynthesis. Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) MVD Bos taurus (Bovine) TR36780_c0_g2_i1 C9JN71 ZN878_HUMAN 3.00E-33 GO:0046872; GO:0003676; GO:0005634; GO:0006355; GO:0006351 "metal ion binding; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 878 ZNF878 Homo sapiens (Human) TR36780_c0_g3_i1 Q6ZN57 ZFP2_HUMAN 1.00E-42 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 2 homolog (Zfp-2) (Zinc finger protein 751) ZFP2 ZNF751 Homo sapiens (Human) TR36780_c0_g3_i2 Q6ZN57 ZFP2_HUMAN 6.00E-47 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 2 homolog (Zfp-2) (Zinc finger protein 751) ZFP2 ZNF751 Homo sapiens (Human) TR36782_c0_g1_i1 Q5RD56 CFLAR_PONAB 2.00E-09 GO:0006915; GO:0004197; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; proteolysis; regulation of apoptotic process IPR011029; IPR001875; IPR011600; IPR001309; IPR015917; CASP8 and FADD-like apoptosis regulator [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12] CFLAR Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36782_c0_g1_i2 Q5IS54 CASP3_PANTR 7.00E-80 GO:0001782; GO:0043029; GO:0006309; GO:0004190; GO:0045165; GO:0071310; GO:0004861; GO:0004197; GO:0005829; GO:0008625; GO:0007507; GO:0008631; GO:0030216; GO:0005739; GO:0030889; GO:0046007; GO:0043066; GO:0045736; GO:0051402; GO:0030264; GO:0005634; GO:0043525; GO:0016485; GO:0006508; GO:0001836; GO:0006974; GO:0009411; GO:0009611; GO:0007605 B cell homeostasis; T cell homeostasis; apoptotic DNA fragmentation; aspartic-type endopeptidase activity; cell fate commitment; cellular response to organic substance; cyclin-dependent protein serine/threonine kinase inhibitor activity; cysteine-type endopeptidase activity; cytosol; extrinsic apoptotic signaling pathway via death domain receptors; heart development; intrinsic apoptotic signaling pathway in response to oxidative stress; keratinocyte differentiation; mitochondrion; negative regulation of B cell proliferation; negative regulation of activated T cell proliferation; negative regulation of apoptotic process; negative regulation of cyclin-dependent protein serine/threonine kinase activity; neuron apoptotic process; nuclear fragmentation involved in apoptotic nuclear change; nucleus; positive regulation of neuron apoptotic process; protein processing; proteolysis; release of cytochrome c from mitochondria; response to DNA damage stimulus; response to UV; response to wounding; sensory perception of sound IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Pan troglodytes (Chimpanzee) TR36783_c0_g1_i1 B3A0Q8 PLSP2_LOTGI 1.00E-19 GO:0005576; GO:0020037; GO:0004601; GO:0006979 extracellular region; heme binding; peroxidase activity; response to oxidative stress IPR010255; IPR002007; IPR019791; Peroxidase-like protein 3 (Fragment) Lottia gigantea (Giant owl limpet) TR36783_c0_g2_i1 P82600 PERC_AEDAE 3.00E-60 GO:0007306; GO:0005576; GO:0020037; GO:0042744; GO:0042743; GO:0046872; GO:0004601 eggshell chorion assembly; extracellular region; heme binding; hydrogen peroxide catabolic process; hydrogen peroxide metabolic process; metal ion binding; peroxidase activity IPR010255; IPR002007; IPR019791; Chorion peroxidase (EC 1.11.1.7) pxt AAEL004386 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR36785_c4_g1_i1 Q504A5 TPMT_DANRE 9.00E-27 GO:0005737; GO:0008119 cytoplasm; thiopurine S-methyltransferase activity IPR025835; IPR008854; Probable thiopurine S-methyltransferase (Thiopurine methyltransferase) (EC 2.1.1.67) tpmt zgc:109981 Danio rerio (Zebrafish) (Brachydanio rerio) TR36785_c4_g1_i2 Q9Z0T0 TPMT_RAT 2.00E-23 GO:0046498; GO:0046500; GO:0005829; GO:0008119; GO:0005923 S-adenosylhomocysteine metabolic process; S-adenosylmethionine metabolic process; cytosol; thiopurine S-methyltransferase activity; tight junction IPR025835; IPR008854; Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) Tpmt Rattus norvegicus (Rat) TR36786_c1_g1_i1 Q8N884 M21D1_HUMAN 7.00E-13 GO:0005524; GO:0003677; GO:0005525; GO:0002218; GO:0071360; GO:0009190; GO:0061501; GO:0005829; GO:0051607; GO:0045087; GO:0046872; GO:0002230; GO:0032481 ATP binding; DNA binding; GTP binding; activation of innate immune response; cellular response to exogenous dsRNA; cyclic nucleotide biosynthetic process; cyclic-GMP-AMP synthase activity; cytosol; defense response to virus; innate immune response; metal ion binding; positive regulation of defense response to virus by host; positive regulation of type I interferon production IPR024810; IPR024805; Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (Mab-21 domain-containing protein 1) MB21D1 C6orf150 Homo sapiens (Human) TR36786_c1_g1_i7 Q8N884 M21D1_HUMAN 4.00E-14 GO:0005524; GO:0003677; GO:0005525; GO:0002218; GO:0071360; GO:0009190; GO:0061501; GO:0005829; GO:0051607; GO:0045087; GO:0046872; GO:0002230; GO:0032481 ATP binding; DNA binding; GTP binding; activation of innate immune response; cellular response to exogenous dsRNA; cyclic nucleotide biosynthetic process; cyclic-GMP-AMP synthase activity; cytosol; defense response to virus; innate immune response; metal ion binding; positive regulation of defense response to virus by host; positive regulation of type I interferon production IPR024810; IPR024805; Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (Mab-21 domain-containing protein 1) MB21D1 C6orf150 Homo sapiens (Human) TR36790_c0_g1_i1 P08548 LIN1_NYCCO 7.00E-33 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR36793_c4_g2_i1 Q92113 CP17A_SQUAC 5.00E-85 GO:0047442; GO:0020037; GO:0005506; GO:0016020; GO:0004508; GO:0006694 17-alpha-hydroxyprogesterone aldolase activity; heme binding; iron ion binding; membrane; steroid 17-alpha-monooxygenase activity; steroid biosynthetic process IPR001128; IPR017972; IPR002401; Lipid metabolism; steroid biosynthesis. "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.99.9) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Squalus acanthias (Spiny dogfish) TR36793_c6_g1_i1 Q54WB9 C513D_DICDI 2.00E-14 GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705 "heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Probable cytochrome P450 513D1 (EC 1.14.-.-) cyp513D1 DDB_G0279763 Dictyostelium discoideum (Slime mold) TR36794_c10_g1_i1 Q2TBS4 PIFO_BOVIN 4.00E-20 GO:0005794; GO:0030030; GO:0016023; GO:0005932; GO:0033674; GO:0031344; GO:0005802 Golgi apparatus; cell projection organization; cytoplasmic membrane-bounded vesicle; microtubule basal body; positive regulation of kinase activity; regulation of cell projection organization; trans-Golgi network IPR010736; Protein pitchfork PIFO Bos taurus (Bovine) TR36794_c2_g1_i1 Q1EHB3 ATS7_RAT 6.00E-09 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS 7) (ADAM-TS7) (ADAMTS-7) (EC 3.4.24.-) (COMPase) Adamts7 Rattus norvegicus (Rat) TR36794_c2_g2_i1 Q26261 UNC5_CAEEL 2.00E-13 GO:0033563; GO:0035262; GO:0016021; GO:0008078; GO:0008045; GO:0005042; GO:0045773; GO:0040017 dorsal/ventral axon guidance; gonad morphogenesis; integral to membrane; mesodermal cell migration; motor neuron axon guidance; netrin receptor activity; positive regulation of axon extension; positive regulation of locomotion IPR011029; IPR000488; IPR007110; IPR013783; IPR003598; IPR000884; IPR000906; Netrin receptor unc-5 (Uncoordinated protein 5) unc-5 B0273.4 Caenorhabditis elegans TR36794_c3_g1_i2 Q24JV9 L3BPA_DANRE 1.00E-14 GO:0007155; GO:0016020; GO:0005578; GO:0005044 cell adhesion; membrane; proteinaceous extracellular matrix; scavenger receptor activity IPR011705; IPR011333; IPR013069; IPR001190; IPR017448; Galectin-3-binding protein A (Lectin galactoside-binding soluble 3-binding protein A) lgals3bpa lgals3bp zgc:136780 Danio rerio (Zebrafish) (Brachydanio rerio) TR36794_c5_g1_i1 P79331 ATS2_BOVIN 1.00E-12 GO:0030574; GO:0030199; GO:0030324; GO:0004222; GO:0016485; GO:0005578; GO:0006508; GO:0043588; GO:0007283; GO:0008270 collagen catabolic process; collagen fibril organization; lung development; metalloendopeptidase activity; protein processing; proteinaceous extracellular matrix; proteolysis; skin development; spermatogenesis; zinc ion binding IPR010294; IPR024079; IPR013275; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS 2) (ADAM-TS2) (ADAMTS-2) (EC 3.4.24.14) (Procollagen I N-proteinase) (PC I-NP) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen N-endopeptidase) (pNPI) ADAMTS2 NPI Bos taurus (Bovine) TR36794_c7_g1_i1 Q96RW7 HMCN1_HUMAN 3.00E-21 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR36794_c9_g1_i1 Q96RW7 HMCN1_HUMAN 5.00E-62 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR36795_c1_g2_i1 Q5HZB0 PORIM_RAT 2.00E-06 GO:0016021 integral to membrane IPR007947; Porimin (Transmembrane protein 123) Tmem123 Rattus norvegicus (Rat) TR36796_c2_g1_i1 Q12983 BNIP3_HUMAN 7.00E-10 GO:0006309; GO:0048102; GO:0050873; GO:0071279; GO:0070301; GO:0071260; GO:0006338; GO:0051607; GO:0030425; GO:0008626; GO:0031307; GO:1990144; GO:0043653; GO:0097345; GO:0035694; GO:0019048; GO:0043066; GO:0045837; GO:0010637; GO:0051402; GO:0005635; GO:0005654; GO:0043065; GO:0090141; GO:0043243; GO:0090200; GO:0046982; GO:0042803; GO:0072593; GO:0055093 Itself; O60238; O60313; P17152 apoptotic DNA fragmentation; autophagic cell death; brown fat cell differentiation; cellular response to cobalt ion; cellular response to hydrogen peroxide; cellular response to mechanical stimulus; chromatin remodeling; defense response to virus; dendrite; granzyme-mediated apoptotic signaling pathway; integral to mitochondrial outer membrane; intrinsic apoptotic signaling pathway in response to hypoxia; mitochondrial fragmentation involved in apoptotic process; mitochondrial outer membrane permeabilization; mitochondrial protein catabolic process; modulation by virus of host morphology or physiology; negative regulation of apoptotic process; negative regulation of membrane potential; negative regulation of mitochondrial fusion; neuron apoptotic process; nuclear envelope; nucleoplasm; positive regulation of apoptotic process; positive regulation of mitochondrial fission; positive regulation of protein complex disassembly; positive regulation of release of cytochrome c from mitochondria; protein heterodimerization activity; protein homodimerization activity; reactive oxygen species metabolic process; response to hyperoxia IPR010548; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 BNIP3 NIP3 Homo sapiens (Human) TR36797_c0_g1_i4 Q8R536 SPRE_MERUN 8.00E-58 GO:0005737; GO:0004757; GO:0006729 cytoplasm; sepiapterin reductase activity; tetrahydrobiopterin biosynthetic process IPR002198; IPR002347; IPR016040; IPR006393; Sepiapterin reductase (SPR) (EC 1.1.1.153) (Benzil reductase ((S)-benzoin forming)) (EC 1.1.1.320) SPR Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) TR36799_c1_g3_i13 Q0IHI3 CB062_XENLA 1.00E-108 IPR003117; Uncharacterized protein C2orf62 homolog Xenopus laevis (African clawed frog) TR36799_c1_g4_i1 Q9UHP6 RTDR1_HUMAN 2.00E-69 IPR011989; IPR016024; Rhabdoid tumor deletion region protein 1 RTDR1 Homo sapiens (Human) TR36800_c0_g1_i1 Q68DK7 MSL1_HUMAN 4.00E-18 GO:0072487; GO:0043984 MSL complex; histone H4-K16 acetylation IPR026711; Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) MSL1 MSL1L1 Homo sapiens (Human) TR36801_c1_g1_i10 Q9W741 NOGG1_DANRE 2.00E-17 GO:0051216; GO:0030154; GO:0009953; GO:0005576; GO:0030514; GO:0042664 cartilage development; cell differentiation; dorsal/ventral pattern formation; extracellular region; negative regulation of BMP signaling pathway; negative regulation of endodermal cell fate specification IPR008717; Noggin-1 nog1 Danio rerio (Zebrafish) (Brachydanio rerio) TR36801_c1_g1_i6 Q9W740 NOGG2_DANRE 4.00E-23 GO:0051216; GO:0030154; GO:0005576; GO:0030514; GO:0045596 cartilage development; cell differentiation; extracellular region; negative regulation of BMP signaling pathway; negative regulation of cell differentiation IPR008717; Noggin-2 nog2 Danio rerio (Zebrafish) (Brachydanio rerio) TR36801_c1_g1_i8 Q9W740 NOGG2_DANRE 3.00E-23 GO:0051216; GO:0030154; GO:0005576; GO:0030514; GO:0045596 cartilage development; cell differentiation; extracellular region; negative regulation of BMP signaling pathway; negative regulation of cell differentiation IPR008717; Noggin-2 nog2 Danio rerio (Zebrafish) (Brachydanio rerio) TR36803_c0_g1_i2 Q3B7G7 SR1IP_DANRE 5.00E-10 GO:0008380; GO:0006397; GO:0003676; GO:0008270 RNA splicing; mRNA processing; nucleic acid binding; zinc ion binding IPR001878; Protein SREK1IP1 srek1ip1 sfrs12ip1 zgc:123019 Danio rerio (Zebrafish) (Brachydanio rerio) TR36803_c0_g1_i7 Q3B7G7 SR1IP_DANRE 2.00E-09 GO:0008380; GO:0006397; GO:0003676; GO:0008270 RNA splicing; mRNA processing; nucleic acid binding; zinc ion binding IPR001878; Protein SREK1IP1 srek1ip1 sfrs12ip1 zgc:123019 Danio rerio (Zebrafish) (Brachydanio rerio) TR36805_c1_g1_i1 Q5PPX0 PPR42_XENLA 1.00E-87 GO:0003779; GO:0005813; GO:0005737; GO:0045502; GO:0002177; GO:0015631 actin binding; centrosome; cytoplasm; dynein binding; manchette; tubulin binding IPR001611; Protein phosphatase 1 regulatory subunit 42 (Leucine-rich repeat-containing protein 67) ppp1r42 lrrc67 Xenopus laevis (African clawed frog) TR36805_c1_g1_i3 Q6GQN5 PPR42_DANRE 7.00E-81 GO:0003779; GO:0005813; GO:0005737; GO:0045502; GO:0002177; GO:0015631 actin binding; centrosome; cytoplasm; dynein binding; manchette; tubulin binding IPR001611; IPR025875; Protein phosphatase 1 regulatory subunit 42 (Leucine-rich repeat-containing protein 67) ppp1r42 lrrc67 zgc:91834 Danio rerio (Zebrafish) (Brachydanio rerio) TR36806_c0_g1_i1 Q95LL2 XRRA1_MACFA 3.00E-13 GO:0005737; GO:0005634; GO:0010165 cytoplasm; nucleus; response to X-ray IPR001611; X-ray radiation resistance-associated protein 1 (Fragment) XRRA1 QtsA-12093 QtsA-20433 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR36806_c0_g1_i2 Q3U3V8 XRRA1_MOUSE 1.00E-15 GO:0005737; GO:0005634; GO:0010165 cytoplasm; nucleus; response to X-ray IPR001611; X-ray radiation resistance-associated protein 1 Xrra1 Mus musculus (Mouse) TR36806_c0_g1_i3 Q6P2D8 XRRA1_HUMAN 7.00E-12 GO:0005737; GO:0005634; GO:0010165 cytoplasm; nucleus; response to X-ray IPR001611; X-ray radiation resistance-associated protein 1 XRRA1 Homo sapiens (Human) TR36809_c0_g1_i2 C0K3N4 VEGFA_AGKPI 3.00E-07 GO:0001525; GO:0030154; GO:0005576; GO:0008201; GO:0016020; GO:0051781; GO:0001938; GO:0051894; GO:0050731; GO:0031334 angiogenesis; cell differentiation; extracellular region; heparin binding; membrane; positive regulation of cell division; positive regulation of endothelial cell proliferation; positive regulation of focal adhesion assembly; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein complex assembly IPR023581; IPR000072; IPR027928; Vascular endothelial growth factor A Agkistrodon piscivorus piscivorus (Eastern cottonmouth) TR36810_c3_g1_i2 Q92546 RGP1_HUMAN 1.00E-111 IPR014848; Retrograde Golgi transport protein RGP1 homolog RGP1 KIAA0258 Homo sapiens (Human) TR36813_c3_g3_i2 P23467 PTPRB_HUMAN 1.00E-46 GO:0001525; GO:0005887; GO:0005001 P04626; P10912; P27361; P08581; Q02763 angiogenesis; integral to plasma membrane; transmembrane receptor protein tyrosine phosphatase activity IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) PTPRB PTPB Homo sapiens (Human) TR36813_c3_g3_i3 P23467 PTPRB_HUMAN 1.00E-42 GO:0001525; GO:0005887; GO:0005001 P04626; P10912; P27361; P08581; Q02763 angiogenesis; integral to plasma membrane; transmembrane receptor protein tyrosine phosphatase activity IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) PTPRB PTPB Homo sapiens (Human) TR36813_c3_g3_i4 P34138 PTP2_DICDI 2.00E-20 GO:0031152; GO:0004725 aggregation involved in sorocarp development; protein tyrosine phosphatase activity IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase 2 (EC 3.1.3.48) (Protein-tyrosine-phosphate phosphohydrolase 2) (PTPA) ptpB ptp2 DDB_G0277865 Dictyostelium discoideum (Slime mold) TR36813_c3_g3_i6 Q64612 PTPRV_RAT 2.00E-37 GO:0046849; GO:0016021; GO:0035335; GO:0004725 bone remodeling; integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase V (R-PTP-V) (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase) (Osteotesticular protein-tyrosine phosphatase) (OST-PTP) Ptprv Esp Rattus norvegicus (Rat) TR36814_c2_g3_i2 O01159 RSP7_CAEEL 2.00E-52 GO:0003723; GO:0000398; GO:0000166; GO:0005634 "RNA binding; mRNA splicing, via spliceosome; nucleotide binding; nucleus" IPR012677; IPR000504; "Probable splicing factor, arginine/serine-rich 7 (p54)" rsp-7 D2089.1 Caenorhabditis elegans TR36814_c2_g3_i3 Q9JKL7 SREK1_RAT 1.00E-39 GO:0008380; GO:0006397; GO:0003676; GO:0000166; GO:0005681 Q92841; P38159; Q15424; P84103; Q16629 RNA splicing; mRNA processing; nucleic acid binding; nucleotide binding; spliceosomal complex IPR012677; IPR000504; "Splicing regulatory glutamine/lysine-rich protein 1 (SR-related protein of 86 kDa) (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12)" Srek1 Sfrs12 Srrp86 Rattus norvegicus (Rat) TR36814_c2_g3_i5 Q6C2Q7 NOP12_YARLI 1.00E-07 GO:0003723; GO:0005730; GO:0000166; GO:0006364 RNA binding; nucleolus; nucleotide binding; rRNA processing IPR012677; IPR000504; Nucleolar protein 12 NOP12 YALI0F05918g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR36814_c2_g3_i7 O01159 RSP7_CAEEL 3.00E-52 GO:0003723; GO:0000398; GO:0000166; GO:0005634 "RNA binding; mRNA splicing, via spliceosome; nucleotide binding; nucleus" IPR012677; IPR000504; "Probable splicing factor, arginine/serine-rich 7 (p54)" rsp-7 D2089.1 Caenorhabditis elegans TR36816_c3_g1_i1 Q9CB01 RABF1_ARATH 2.00E-43 GO:0005525; GO:0003924; GO:0005769; GO:0031901; GO:0045022; GO:0006897; GO:0010009; GO:0005886; GO:0015031; GO:0007264 GTP binding; GTPase activity; early endosome; early endosome membrane; early endosome to late endosome transport; endocytosis; external side of endosome membrane; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein RABF1 (AtRABF1) (Ras-related protein Ara-6) (Ras-related protein Rab5C) (AtRab5C) RABF1 ARA-6 RAB5C At3g54840 F28P10.180 Arabidopsis thaliana (Mouse-ear cress) TR36816_c3_g1_i2 Q13636 RAB31_HUMAN 4.00E-51 GO:0019003; GO:0005525; GO:0003924; GO:0005794; GO:0043001; GO:0032869; GO:0005769; GO:0045335; GO:0030670; GO:0090382; GO:0031623; GO:0045055; GO:0007264; GO:0032588 GDP binding; GTP binding; GTPase activity; Golgi apparatus; Golgi to plasma membrane protein transport; cellular response to insulin stimulus; early endosome; phagocytic vesicle; phagocytic vesicle membrane; phagosome maturation; receptor internalization; regulated secretory pathway; small GTPase mediated signal transduction; trans-Golgi network membrane IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-31 (Ras-related protein Rab-22B) RAB31 RAB22B Homo sapiens (Human) TR36816_c3_g1_i4 A6NDJ8 RB43L_HUMAN 5.00E-34 GO:0005525; GO:0015031; GO:0007264 GTP binding; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Putative Rab-43-like protein ENSP00000330714 Homo sapiens (Human) TR36819_c2_g1_i1 Q03168 ASPP_AEDAE 4.00E-18 GO:0004190; GO:0005764; GO:0006508 aspartic-type endopeptidase activity; lysosome; proteolysis IPR001461; IPR001969; IPR012848; IPR021109; Lysosomal aspartic protease (EC 3.4.23.-) AAEL006169 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR36820_c3_g1_i1 Q9NZR2 LRP1B_HUMAN 1.00E-14 GO:0005509; GO:0016021; GO:0005041; GO:0015031; GO:0006898 calcium ion binding; integral to membrane; low-density lipoprotein receptor activity; protein transport; receptor-mediated endocytosis IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) LRP1B LRPDIT Homo sapiens (Human) TR36820_c3_g1_i2 Q98930 SORL_CHICK 1.00E-10 GO:0008203; GO:0006897; GO:0016021; GO:0006869; GO:0034362 cholesterol metabolic process; endocytosis; integral to membrane; lipid transport; low-density lipoprotein particle IPR011042; IPR003961; IPR013783; IPR023415; IPR000033; IPR002172; IPR006581; Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (Fragment) SORL1 Gallus gallus (Chicken) TR36820_c3_g1_i3 P98157 LRP1_CHICK 1.00E-11 GO:0005509; GO:0005905; GO:0006897; GO:0016021 calcium ion binding; coated pit; endocytosis; integral to membrane IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) LRP1 Gallus gallus (Chicken) TR36820_c3_g1_i4 Q95209 SORL_RABIT 1.00E-11 GO:0005794; GO:0008203; GO:0006897; GO:0005768; GO:0005615; GO:0016021; GO:0006869; GO:0034362; GO:0016020; GO:0006605; GO:0014910 Golgi apparatus; cholesterol metabolic process; endocytosis; endosome; extracellular space; integral to membrane; lipid transport; low-density lipoprotein particle; membrane; protein targeting; regulation of smooth muscle cell migration IPR011042; IPR000742; IPR003961; IPR013783; IPR023415; IPR000033; IPR002172; IPR006581; IPR015943; Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) SORL1 Oryctolagus cuniculus (Rabbit) TR36820_c3_g1_i5 Q9JI18 LRP1B_MOUSE 2.00E-13 GO:0005509; GO:0016021; GO:0050750; GO:0005041; GO:0016020 Q9WVI9-1; Q80VC8; P69566 calcium ion binding; integral to membrane; low-density lipoprotein particle receptor binding; low-density lipoprotein receptor activity; membrane IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) Lrp1b Lrpdit Mus musculus (Mouse) TR36820_c3_g1_i6 P98155 VLDLR_HUMAN 1.00E-10 GO:0034185; GO:0005509; GO:0008203; GO:0005905; GO:0034436; GO:0034437; GO:0016021; GO:0006869; GO:0005041; GO:0007613; GO:0000122; GO:0005886; GO:1900006; GO:0045860; GO:0038025; GO:0021517; GO:0034361; GO:0034189; GO:0034447; GO:0030229 apolipoprotein binding; calcium ion binding; cholesterol metabolic process; coated pit; glycoprotein transport; glycoprotein transporter activity; integral to membrane; lipid transport; low-density lipoprotein receptor activity; memory; negative regulation of transcription from RNA polymerase II promoter; plasma membrane; positive regulation of dendrite development; positive regulation of protein kinase activity; reelin receptor activity; ventral spinal cord development; very-low-density lipoprotein particle; very-low-density lipoprotein particle binding; very-low-density lipoprotein particle clearance; very-low-density lipoprotein particle receptor activity IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023415; IPR000033; IPR002172; Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) VLDLR Homo sapiens (Human) TR36822_c7_g3_i2 A6H8J1 PRRCA_XENLA 2.00E-78 GO:0005794 Golgi apparatus IPR026533; IPR026534; Protein PRRC1-A (Proline-rich and coiled-coil-containing protein 1-A) prrc1-a Xenopus laevis (African clawed frog) TR36823_c1_g2_i2 Q9Z0M5 LICH_MOUSE 3.00E-84 GO:0000902; GO:0008283; GO:0001816; GO:0048873; GO:0006954; GO:0016298; GO:0016042; GO:0030324; GO:0005764; GO:0004771; GO:0048771 cell morphogenesis; cell proliferation; cytokine production; homeostasis of number of cells within a tissue; inflammatory response; lipase activity; lipid catabolic process; lung development; lysosome; sterol esterase activity; tissue remodeling IPR000073; IPR006693; IPR025483; Lysosomal acid lipase/cholesteryl ester hydrolase (Acid cholesteryl ester hydrolase) (LAL) (EC 3.1.1.13) (Cholesteryl esterase) (Lipase A) (Sterol esterase) Lipa Lip1 Mus musculus (Mouse) TR36825_c3_g1_i1 P61800 APTX_TAKRU 5.00E-62 GO:0003677; GO:0006281; GO:0016787; GO:0046872; GO:0005730; GO:0005654 DNA binding; DNA repair; hydrolase activity; metal ion binding; nucleolus; nucleoplasm IPR000253; IPR019808; IPR001310; IPR011146; IPR008984; IPR007087; IPR015880; Aprataxin (EC 3.-.-.-) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) aptx Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR36825_c5_g1_i1 Q9NXC5 MIO_HUMAN 0 GO:0005765 lysosomal membrane IPR015943; IPR001680; IPR017986; WD repeat-containing protein mio MIOS Homo sapiens (Human) TR36826_c3_g3_i2 P34275 IVD_CAEEL 7.00E-146 GO:0003995; GO:0050660; GO:0006552 acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; leucine catabolic process IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3. Probable acyl-CoA dehydrogenase 6 (Probable isovaleryl-CoA dehydrogenase) (IVD) (EC 1.3.8.4) acdh-6 C02D5.1 Caenorhabditis elegans TR36829_c6_g1_i2 Q9Y4B6 VPRBP_HUMAN 2.00E-130 GO:0005737; GO:0019048; GO:0005634; GO:0016567 Q16531; P12520; P18045; P19508 cytoplasm; modulation by virus of host morphology or physiology; nucleus; protein ubiquitination IPR011989; IPR016024; IPR006594; IPR015943; IPR017986; Protein modification; protein ubiquitination. Protein VPRBP (DDB1- and CUL4-associated factor 1) (HIV-1 Vpr-binding protein) (VprBP) (Vpr-interacting protein) VPRBP DCAF1 KIAA0800 RIP Homo sapiens (Human) TR36833_c1_g1_i1 Q28EH9 T194A_XENTR 6.00E-40 GO:0016021 integral to membrane IPR019358; Transmembrane protein 194A tmem194a TTpA010p19.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36835_c1_g1_i1 Q9QXN3 TRIP4_MOUSE 1.00E-113 GO:0005737; GO:0005815; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "cytoplasm; microtubule organizing center; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR007374; IPR015947; IPR009349; Activating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TR-interacting protein 4) (TRIP-4) Trip4 Mus musculus (Mouse) TR36835_c1_g1_i2 O13855 YEX1_SCHPO 3.00E-13 GO:0005829; GO:0005634; GO:0006357; GO:0003713; GO:0008270 cytosol; nucleus; regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; zinc ion binding IPR009349; Uncharacterized protein C1A6.01c SPAC1A6.01c SPAC23C4.20c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36836_c2_g1_i1 O43301 HS12A_HUMAN 2.00E-28 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR36836_c3_g1_i1 Q13263 TIF1B_HUMAN 2.00E-09 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR36836_c4_g2_i1 Q68XG8 HSCA_RICTY 4.00E-06 GO:0005524; GO:0016887; GO:0016226; GO:0006457 ATP binding; ATPase activity; iron-sulfur cluster assembly; protein folding IPR018181; IPR013126; IPR010236; Chaperone protein HscA homolog hscA RT0190 Rickettsia typhi (strain ATCC VR-144 / Wilmington) TR36836_c4_g2_i2 Q8K0U4 HS12A_MOUSE 5.00E-60 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR3684_c0_g1_i1 Q70CQ2 UBP34_HUMAN 6.00E-16 GO:0016055; GO:0004197; GO:0090263; GO:0071108; GO:0004221; GO:0006511; GO:0004843 Wnt receptor signaling pathway; cysteine-type endopeptidase activity; positive regulation of canonical Wnt receptor signaling pathway; protein K48-linked deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR016024; IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) USP34 KIAA0570 KIAA0729 Homo sapiens (Human) TR36840_c1_g1_i1 O14308 SWC4_SCHPO 2.00E-29 GO:0003677; GO:0006281; GO:0035267; GO:0000812; GO:0003682; GO:0006338; GO:0043968; GO:0043967; GO:0006355; GO:0006351 "DNA binding; DNA repair; NuA4 histone acetyltransferase complex; Swr1 complex; chromatin binding; chromatin remodeling; histone H2A acetylation; histone H4 acetylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001005; IPR027109; SWR1-complex protein 4 swc4 SPAC9G1.13c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36840_c1_g1_i2 Q9JI44 DMAP1_MOUSE 4.00E-157 GO:0006281; GO:0035267; GO:0001103; GO:0003682; GO:0006338; GO:0005737; GO:0043968; GO:0043967; GO:0000122; GO:0042993; GO:0040008; GO:0005657; GO:0003714; GO:0006351 "DNA repair; NuA4 histone acetyltransferase complex; RNA polymerase II repressing transcription factor binding; chromatin binding; chromatin remodeling; cytoplasm; histone H2A acetylation; histone H4 acetylation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor import into nucleus; regulation of growth; replication fork; transcription corepressor activity; transcription, DNA-dependent" IPR008468; IPR001005; IPR027109; DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) (MAT1-mediated transcriptional repressor) Dmap1 Mmtr Mus musculus (Mouse) TR36845_c1_g1_i1 Q9Z319 CORIN_MOUSE 3.00E-08 GO:0009986; GO:0005576; GO:0007565; GO:0005887; GO:0030182; GO:0016486; GO:0006508; GO:0035813; GO:0003050; GO:0005044; GO:0004252; GO:0070008 cell surface; extracellular region; female pregnancy; integral to plasma membrane; neuron differentiation; peptide hormone processing; proteolysis; regulation of renal sodium excretion; regulation of systemic arterial blood pressure by atrial natriuretic peptide; scavenger receptor activity; serine-type endopeptidase activity; serine-type exopeptidase activity IPR020067; IPR023415; IPR002172; IPR001254; IPR018114; IPR017052; IPR001190; IPR017448; IPR009003; "Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Low density lipoprotein receptor-related protein 4) (Pro-ANP-converting enzyme) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment]" Corin Crn Lrp4 Mus musculus (Mouse) TR36845_c1_g1_i2 P35953 VLDLR_RABIT 1.00E-06 GO:0005509; GO:0008203; GO:0005905; GO:0034436; GO:0034437; GO:0016021; GO:0006869; GO:0000122; GO:1900006; GO:0038025; GO:0021517; GO:0034361; GO:0034189; GO:0034447; GO:0030229 calcium ion binding; cholesterol metabolic process; coated pit; glycoprotein transport; glycoprotein transporter activity; integral to membrane; lipid transport; negative regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite development; reelin receptor activity; ventral spinal cord development; very-low-density lipoprotein particle; very-low-density lipoprotein particle binding; very-low-density lipoprotein particle clearance; very-low-density lipoprotein particle receptor activity IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) VLDLR Oryctolagus cuniculus (Rabbit) TR36845_c1_g1_i3 Q5VYJ5 CJ112_HUMAN 2.00E-24 GO:0016021 integral to membrane IPR008985; IPR023415; IPR002172; IPR000998; MAM and LDL-receptor class A domain-containing protein C10orf112 C10orf112 Homo sapiens (Human) TR36845_c1_g1_i4 Q0WYX8 MDGA1_CHICK 3.00E-22 GO:0046658; GO:0001764 anchored to plasma membrane; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 MDGA1 Gallus gallus (Chicken) TR36846_c0_g1_i2 Q8T8R1 Y3800_DROME 1.00E-08 GO:0003676; GO:0008270 nucleic acid binding; zinc ion binding IPR001878; CCHC-type zinc finger protein CG3800 CG3800 Drosophila melanogaster (Fruit fly) TR36846_c0_g1_i5 A1L2T6 ZCHC7_XENLA 5.00E-38 GO:0003676; GO:0008270 nucleic acid binding; zinc ion binding IPR001878; Zinc finger CCHC domain-containing protein 7 zcchc7 Xenopus laevis (African clawed frog) TR36847_c0_g1_i1 Q9VTT9 DEFI8_DROME 3.00E-86 GO:0035556; GO:0008270 Q9VJL7; Q9VXR6 intracellular signal transduction; zinc ion binding IPR025258; IPR002219; IPR001965; IPR001841; Differentially expressed in FDCP 8 homolog CG11534 Drosophila melanogaster (Fruit fly) TR36847_c0_g1_i2 Q6DJB3 DEFI8_XENTR 3.00E-143 GO:0035556; GO:0008270 intracellular signal transduction; zinc ion binding IPR025258; IPR002219; IPR001841; Differentially expressed in FDCP 8 homolog (DEF-8) def8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36847_c0_g1_i5 Q80U62 RUBIC_MOUSE 2.00E-35 GO:0005794; GO:0006914; GO:0005769; GO:0006897; GO:0005770; GO:0005764; GO:0010507; GO:0045806 Golgi apparatus; autophagy; early endosome; endocytosis; late endosome; lysosome; negative regulation of autophagy; negative regulation of endocytosis IPR025258; IPR004012; Run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) Kiaa0226 Mus musculus (Mouse) TR36847_c0_g1_i6 Q9VTT9 DEFI8_DROME 2.00E-86 GO:0035556; GO:0008270 Q9VJL7; Q9VXR6 intracellular signal transduction; zinc ion binding IPR025258; IPR002219; IPR001965; IPR001841; Differentially expressed in FDCP 8 homolog CG11534 Drosophila melanogaster (Fruit fly) TR36847_c0_g1_i7 Q6DJB3 DEFI8_XENTR 5.00E-143 GO:0035556; GO:0008270 intracellular signal transduction; zinc ion binding IPR025258; IPR002219; IPR001841; Differentially expressed in FDCP 8 homolog (DEF-8) def8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36848_c0_g1_i1 Q4VBE8 WDR18_MOUSE 7.00E-108 GO:0005737; GO:0007275; GO:0005654 cytoplasm; multicellular organismal development; nucleoplasm IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; IPR026987; WD repeat-containing protein 18 Wdr18 Mus musculus (Mouse) TR36848_c0_g1_i2 Q4VBE8 WDR18_MOUSE 2.00E-107 GO:0005737; GO:0007275; GO:0005654 cytoplasm; multicellular organismal development; nucleoplasm IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; IPR026987; WD repeat-containing protein 18 Wdr18 Mus musculus (Mouse) TR36848_c0_g1_i3 Q7T0W1 BOP1A_XENLA 8.00E-11 GO:0070545; GO:0000463; GO:0005654; GO:0051726 "PeBoW complex; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleoplasm; regulation of cell cycle" IPR012953; IPR015943; IPR001680; IPR019775; IPR017986; Ribosome biogenesis protein bop1-A (Block of proliferation 1 protein A) bop1-a Xenopus laevis (African clawed frog) TR36849_c1_g1_i1 Q6IFT6 ANO7_RAT 3.00E-08 GO:0005254; GO:0005783; GO:0016021; GO:0005634; GO:0005886 chloride channel activity; endoplasmic reticulum; integral to membrane; nucleus; plasma membrane IPR007632; Anoctamin-7 (New gene expressed in prostate homolog) (Transmembrane protein 16G) Ano7 Ngep Tmem16g Rattus norvegicus (Rat) TR36849_c8_g1_i1 Q6IWH7 ANO7_HUMAN 3.00E-33 GO:0030054; GO:0005254; GO:0005829; GO:0005783; GO:0016021; GO:0034220; GO:0005634; GO:0005886 cell junction; chloride channel activity; cytosol; endoplasmic reticulum; integral to membrane; ion transmembrane transport; nucleus; plasma membrane IPR007632; Anoctamin-7 (Dresden transmembrane protein of the prostate) (D-TMPP) (IPCA-5) (New gene expressed in prostate) (Prostate cancer-associated protein 5) (Transmembrane protein 16G) ANO7 NGEP PCANAP5 TMEM16G Homo sapiens (Human) TR36850_c3_g1_i1 P11139 TBA1_ARATH 8.00E-13 GO:0005525; GO:0003924; GO:0005829; GO:0005874; GO:0007017; GO:0005886; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytosol; microtubule; microtubule-based process; plasma membrane; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR013838; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-1 chain TUBA1 TUA1 At1g64740 F13O11.5 Arabidopsis thaliana (Mouse-ear cress) TR36851_c0_g1_i1 P11845 IPP2_RABIT 1.00E-18 GO:0005977; GO:0004864; GO:0043666; GO:0009966 glycogen metabolic process; protein phosphatase inhibitor activity; regulation of phosphoprotein phosphatase activity; regulation of signal transduction IPR007062; Protein phosphatase inhibitor 2 (IPP-2) PPP1R2 IPP2 Oryctolagus cuniculus (Rabbit) TR36851_c0_g1_i2 P11845 IPP2_RABIT 9.00E-14 GO:0005977; GO:0004864; GO:0043666; GO:0009966 glycogen metabolic process; protein phosphatase inhibitor activity; regulation of phosphoprotein phosphatase activity; regulation of signal transduction IPR007062; Protein phosphatase inhibitor 2 (IPP-2) PPP1R2 IPP2 Oryctolagus cuniculus (Rabbit) TR36852_c0_g1_i1 Q5ZJD3 LSG1_CHICK 7.00E-97 GO:0015030; GO:0005525; GO:0003924; GO:0005829; GO:0005783; GO:0051168; GO:0015031; GO:0042254 Cajal body; GTP binding; GTPase activity; cytosol; endoplasmic reticulum; nuclear export; protein transport; ribosome biogenesis IPR006073; IPR027417; Large subunit GTPase 1 homolog (EC 3.6.1.-) LSG1 RCJMB04_19c19 Gallus gallus (Chicken) TR36852_c0_g1_i3 Q6NY89 LSG1_DANRE 6.00E-97 GO:0015030; GO:0005525; GO:0003924; GO:0005829; GO:0005783; GO:0051168; GO:0015031; GO:0042254 Cajal body; GTP binding; GTPase activity; cytosol; endoplasmic reticulum; nuclear export; protein transport; ribosome biogenesis IPR006073; IPR027417; Large subunit GTPase 1 homolog (EC 3.6.1.-) lsg1 zgc:76988 Danio rerio (Zebrafish) (Brachydanio rerio) TR36852_c0_g1_i4 O67679 ENGB_AQUAE 1.00E-07 GO:0005525; GO:0000917 GTP binding; barrier septum assembly IPR019987; IPR006073; IPR027417; IPR005225; Probable GTP-binding protein EngB engB aq_1815 Aquifex aeolicus (strain VF5) TR36853_c1_g1_i1 Q9CXE6 XRCC3_MOUSE 3.00E-77 GO:0005524; GO:0003677; GO:0006310; GO:0006281; GO:0008094; GO:0005759; GO:0005634; GO:0048471 ATP binding; DNA binding; DNA recombination; DNA repair; DNA-dependent ATPase activity; mitochondrial matrix; nucleus; perinuclear region of cytoplasm IPR013632; IPR016467; IPR020588; IPR027417; DNA repair protein XRCC3 (X-ray repair cross-complementing protein 3) Xrcc3 Mus musculus (Mouse) TR36854_c2_g1_i2 P22897 MRC1_HUMAN 4.00E-07 GO:0010008; GO:0005887; GO:0005537; GO:0004872; GO:0006898 endosome membrane; integral to plasma membrane; mannose binding; receptor activity; receptor-mediated endocytosis IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206) MRC1 CLEC13D CLEC13DL MRC1L1 Homo sapiens (Human) TR36854_c2_g1_i4 Q61830 MRC1_MOUSE 3.00E-09 GO:0009986; GO:0010008; GO:0016021; GO:0005537; GO:0005886; GO:0006898; GO:0004888 cell surface; endosome membrane; integral to membrane; mannose binding; plasma membrane; receptor-mediated endocytosis; transmembrane signaling receptor activity IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; Macrophage mannose receptor 1 (MMR) (CD antigen CD206) Mrc1 Mus musculus (Mouse) TR36854_c2_g2_i1 Q8TE56 ATS17_HUMAN 2.00E-08 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; IPR007087; A disintegrin and metalloproteinase with thrombospondin motifs 17 (ADAM-TS 17) (ADAM-TS17) (ADAMTS-17) (EC 3.4.24.-) ADAMTS17 Homo sapiens (Human) TR36854_c2_g2_i2 Q03350 TSP2_MOUSE 2.00E-13 GO:0005604; GO:0005509; GO:0007155; GO:0008201; GO:0016525 Q63722; Q07954 basement membrane; calcium ion binding; cell adhesion; heparin binding; negative regulation of angiogenesis IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR024731; IPR001791; IPR000884; IPR015455; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-2 Thbs2 Tsp2 Mus musculus (Mouse) TR36855_c1_g2_i8 Q9UK45 LSM7_HUMAN 5.00E-48 GO:0017070; GO:0005829; GO:0043928; GO:0000398; GO:0005634; GO:0005681 Q9Y333; P62310; Q9Y4Z0; Q9Y4Y9; P62312; P62318; O75410-1; O75410-6 "U6 snRNA binding; cytosol; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; mRNA splicing, via spliceosome; nucleus; spliceosomal complex" IPR010920; IPR001163; IPR006649; IPR017132; U6 snRNA-associated Sm-like protein LSm7 LSM7 Homo sapiens (Human) TR36856_c3_g2_i1 Q60847 COCA1_MOUSE 2.00E-23 GO:0007155; GO:0005581; GO:0005615; GO:0070062 cell adhesion; collagen; extracellular space; extracellular vesicular exosome IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain Col12a1 Mus musculus (Mouse) TR36856_c3_g2_i2 A2AX52 CO6A4_MOUSE 5.00E-27 GO:0007155; GO:0005581; GO:0005576; GO:0043234; GO:0070208 cell adhesion; collagen; extracellular region; protein complex; protein heterotrimerization IPR008160; IPR002035; Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) TR36856_c3_g2_i3 A6NMZ7 CO6A6_HUMAN 3.00E-31 GO:0007155; GO:0005581; GO:0030574; GO:0031012; GO:0022617; GO:0005576 cell adhesion; collagen; collagen catabolic process; extracellular matrix; extracellular matrix disassembly; extracellular region IPR008160; IPR002035; Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) TR36856_c3_g4_i1 A2AX52 CO6A4_MOUSE 2.00E-23 GO:0007155; GO:0005581; GO:0005576; GO:0043234; GO:0070208 cell adhesion; collagen; extracellular region; protein complex; protein heterotrimerization IPR008160; IPR002035; Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) TR36857_c1_g1_i2 Q29S22 DDX47_BOVIN 0 GO:0005524; GO:0008026; GO:0003723; GO:0008380; GO:0008625; GO:0006397; GO:0005730; GO:0006364 ATP binding; ATP-dependent helicase activity; RNA binding; RNA splicing; extrinsic apoptotic signaling pathway via death domain receptors; mRNA processing; nucleolus; rRNA processing IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX47 (EC 3.6.4.13) (DEAD box protein 47) DDX47 Bos taurus (Bovine) TR36857_c1_g1_i3 Q8N8A6 DDX51_HUMAN 2.00E-19 GO:0005524; GO:0008026; GO:0003723; GO:0005730; GO:0006364 ATP binding; ATP-dependent helicase activity; RNA binding; nucleolus; rRNA processing IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; ATP-dependent RNA helicase DDX51 (EC 3.6.4.13) (DEAD box protein 51) DDX51 Homo sapiens (Human) TR36857_c1_g2_i1 Q2HCV7 ROK1_CHAGB 4.00E-15 GO:0005524; GO:0008026; GO:0003723; GO:0005730; GO:0006364 ATP binding; ATP-dependent helicase activity; RNA binding; nucleolus; rRNA processing IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; ATP-dependent RNA helicase ROK1 (EC 3.6.4.13) ROK1 CHGG_01947 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) TR36857_c2_g2_i7 A2A791 ZMYM4_MOUSE 4.00E-06 GO:0007010; GO:0022604; GO:0008270 cytoskeleton organization; regulation of cell morphogenesis; zinc ion binding IPR021893; IPR011017; IPR010507; Zinc finger MYM-type protein 4 (Zinc finger protein 262) Zmym4 Kiaa0425 Zfp262 Znf262 Mus musculus (Mouse) TR36858_c0_g2_i3 Q09002 STM2B_XENLA 6.00E-09 GO:0005737; GO:0016020; GO:0031110 cytoplasm; membrane; regulation of microtubule polymerization or depolymerization IPR026729; IPR000956; Stathmin-2-B (SCG10 protein homolog B) stmn2-b Xenopus laevis (African clawed frog) TR36859_c8_g1_i1 O15040 TCPR2_HUMAN 3.00E-106 GO:0006914; GO:0008219 O95166; Q9H0R8; P60520; Q9BXW4 autophagy; cell death IPR006624; IPR009091; IPR015943; IPR001680; IPR017986; Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297) TECPR2 KIAA0297 KIAA0329 Homo sapiens (Human) TR36860_c0_g1_i1 Q5E9C0 RSU1_BOVIN 7.00E-101 IPR001611; IPR025875; IPR003591; Ras suppressor protein 1 (Rsu-1) RSU1 Bos taurus (Bovine) TR36860_c0_g1_i2 Q5E9C0 RSU1_BOVIN 6.00E-101 IPR001611; IPR025875; IPR003591; Ras suppressor protein 1 (Rsu-1) RSU1 Bos taurus (Bovine) TR36861_c3_g2_i1 Q8C436 MT21D_MOUSE 1.00E-57 GO:0005737; GO:0018023; GO:0016279 cytoplasm; peptidyl-lysine trimethylation; protein-lysine N-methyltransferase activity IPR019410; Protein-lysine methyltransferase METTL21D (EC 2.1.1.-) (Methyltransferase-like protein 21D) (VCP lysine methyltransferase) (VCP-KMT) (Valosin-containing protein lysine methyltransferase) Vcpkmt Gm71 Mettl21d Mus musculus (Mouse) TR36862_c2_g1_i1 Q9NYT6 ZN226_HUMAN 5.00E-52 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 226 ZNF226 Homo sapiens (Human) TR36862_c2_g1_i3 Q86V71 ZN429_HUMAN 4.00E-44 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 429 ZNF429 Homo sapiens (Human) TR36864_c0_g1_i1 P95896 AMID_SULSO 3.00E-148 GO:0004040; GO:0016884 "amidase activity; carbon-nitrogen ligase activity, with glutamine as amido-N-donor" IPR000120; IPR020556; IPR023631; Amidase (EC 3.5.1.4) SSO2122 C02016 C02_017 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) TR36864_c0_g1_i2 P95896 AMID_SULSO 2.00E-148 GO:0004040; GO:0016884 "amidase activity; carbon-nitrogen ligase activity, with glutamine as amido-N-donor" IPR000120; IPR020556; IPR023631; Amidase (EC 3.5.1.4) SSO2122 C02016 C02_017 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) TR36865_c0_g1_i3 Q24799 MYPH_ECHGR 8.00E-37 IPR000557; IPR001715; IPR003096; Myophilin Echinococcus granulosus TR36865_c0_g1_i8 P37805 TAGL3_RAT 2.00E-33 GO:0007517; GO:0000122; GO:0005634 muscle organ development; negative regulation of transcription from RNA polymerase II promoter; nucleus IPR000557; IPR001715; IPR003096; IPR001061; Transgelin-3 (Neuronal protein 22) (NP22) (Neuronal protein NP25) Tagln3 Np25 Rattus norvegicus (Rat) TR36866_c13_g3_i1 Q9ULI3 HEG1_HUMAN 6.00E-09 GO:0005509; GO:0003209; GO:0005911; GO:0045216; GO:0001886; GO:0009897; GO:0005576; GO:0001701; GO:0016021; GO:0030324; GO:0003017; GO:0001945; GO:0035264; GO:0060039; GO:0009791; GO:0050878; GO:0001570; GO:0048845; GO:0003281 calcium ion binding; cardiac atrium morphogenesis; cell-cell junction; cell-cell junction organization; endothelial cell morphogenesis; external side of plasma membrane; extracellular region; in utero embryonic development; integral to membrane; lung development; lymph circulation; lymph vessel development; multicellular organism growth; pericardium development; post-embryonic development; regulation of body fluid levels; vasculogenesis; venous blood vessel morphogenesis; ventricular septum development IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; Protein HEG homolog 1 HEG1 KIAA1237 Homo sapiens (Human) TR36866_c13_g3_i2 Q80YA8 CRUM2_MOUSE 1.00E-08 GO:0005509; GO:0016021; GO:0050896 calcium ion binding; integral to membrane; response to stimulus IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protein crumbs homolog 2 (Crumbs-like protein 2) Crb2 Mus musculus (Mouse) TR36867_c0_g2_i1 Q95LR0 AAT1_MACFA 1.00E-79 GO:0005739 mitochondrion IPR026720; Protein MAATS1 (AMY-1-associating protein expressed in testis 1) (AAT-1) (MYCBP/AMY-1-associated testis-expressed protein 1) MAATS1 AAT1 QtsA-10510 QtsA-13847 QtsA-19865 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR36868_c0_g2_i1 Q9V4P1 ANLN_DROME 2.00E-79 GO:0003779; GO:0005826; GO:0051297; GO:0000915; GO:0032189; GO:0035323; GO:0030726; GO:0007112; GO:0007126; GO:0008017; GO:0007067; GO:0017022; GO:0022008; GO:0005634; GO:0048477; GO:0005543; GO:0007009; GO:0007279; GO:0051533; GO:0008104; GO:0045035; GO:0031106 "actin binding; actomyosin contractile ring; centrosome organization; cytokinesis, actomyosin contractile ring assembly; maintenance of actomyosin contractile ring localization; male germline ring canal; male germline ring canal formation; male meiosis cytokinesis; meiosis; microtubule binding; mitosis; myosin binding; neurogenesis; nucleus; oogenesis; phospholipid binding; plasma membrane organization; pole cell formation; positive regulation of NFAT protein import into nucleus; protein localization; sensory organ precursor cell division; septin ring organization" IPR012966; IPR011993; IPR001849; Actin-binding protein anillin (Actin-binding protein 8) (ABP8) (Protein scraps) scra ani CG2092 Drosophila melanogaster (Fruit fly) TR36868_c0_g2_i2 Q801E2 ANLN_XENLA 5.00E-89 GO:0005938; GO:0051301; GO:0005856; GO:0007067; GO:0005634; GO:0005543 cell cortex; cell division; cytoskeleton; mitosis; nucleus; phospholipid binding IPR012966; IPR011993; IPR001849; Actin-binding protein anillin anln Xenopus laevis (African clawed frog) TR36869_c6_g1_i1 O97394 SDK_DROME 7.00E-11 GO:0007155; GO:0042675; GO:0005887; GO:0046533; GO:0050931 cell adhesion; compound eye cone cell differentiation; integral to plasma membrane; negative regulation of photoreceptor cell differentiation; pigment cell differentiation IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Protein sidekick sdk CG5227 Drosophila melanogaster (Fruit fly) TR36869_c8_g1_i1 A4QN59 DPH2_DANRE 8.00E-150 GO:0005737; GO:0017183 cytoplasm; peptidyl-diphthamide biosynthetic process from peptidyl-histidine IPR010014; IPR002728; Protein modification; peptidyl-diphthamide biosynthesis. Diphthamide biosynthesis protein 2 (DPH2 homolog) dph2 zgc:162269 Danio rerio (Zebrafish) (Brachydanio rerio) TR36869_c8_g1_i2 Q5B2Q1 DPH2_EMENI 5.00E-45 GO:0005737; GO:0017183 cytoplasm; peptidyl-diphthamide biosynthetic process from peptidyl-histidine IPR010014; IPR002728; Protein modification; peptidyl-diphthamide biosynthesis. Diphthamide biosynthesis protein 2 dph2 AN5179 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR36869_c8_g1_i3 Q3T7C9 DPH1_LITVA 5.00E-18 GO:0006915; GO:0005737; GO:0017183 apoptotic process; cytoplasm; peptidyl-diphthamide biosynthetic process from peptidyl-histidine IPR002728; IPR016435; Protein modification; peptidyl-diphthamide biosynthesis. Diphthamide biosynthesis protein 1 (DPH1 homolog) (Tumor suppressor-like protein) (TSL) Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei) TR36873_c2_g1_i3 Q9XSK2 CD63_BOVIN 4.00E-07 GO:0016021; GO:0031902; GO:0005765; GO:0005886 integral to membrane; late endosome membrane; lysosomal membrane; plasma membrane IPR000301; IPR018499; IPR018503; IPR008952; CD63 antigen (CD antigen CD63) CD63 Bos taurus (Bovine) TR36875_c2_g3_i4 Q8IYB1 M21D2_HUMAN 6.00E-07 IPR024810; IPR024803; Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) TR36875_c2_g3_i7 Q8IYB1 M21D2_HUMAN 6.00E-07 IPR024810; IPR024803; Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) TR36876_c4_g1_i1 Q6ITT3 MGT4C_PIG 7.00E-73 GO:0000139; GO:0008454; GO:0016021; GO:0046872; GO:0006486 "Golgi membrane; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; integral to membrane; metal ion binding; protein glycosylation" IPR006759; Protein modification; protein glycosylation. "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)" MGAT4C Sus scrofa (Pig) TR36876_c4_g1_i2 Q9DGD1 MGT4C_CHICK 5.00E-59 GO:0000139; GO:0008454; GO:0016021; GO:0046872; GO:0006486 "Golgi membrane; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; integral to membrane; metal ion binding; protein glycosylation" IPR006759; Protein modification; protein glycosylation. "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.-) (EC 2.4.1.145) (N-acetylglucosaminyltransferase VI) (GnT-VI) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)" MGAT4C Gallus gallus (Chicken) TR36876_c5_g3_i1 P18625 FOSL2_CHICK 5.00E-18 GO:0005634; GO:0043565; GO:0003700 nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR004827; IPR000837; Fos-related antigen 2 (FRA-2) FOSL2 FRA-2 Gallus gallus (Chicken) TR36876_c5_g3_i7 P10158 FOSL1_RAT 6.00E-16 GO:0003677; GO:0000977; GO:0031668; GO:0005829; GO:0007565; GO:0001701; GO:0007612; GO:0008285; GO:0043005; GO:0005634; GO:0060674; GO:0043065; GO:0045787; GO:0051091; GO:0042734; GO:0051591; GO:0051412; GO:0034097; GO:0042493; GO:0009629; GO:0042542; GO:0009612; GO:0032570; GO:0003700; GO:0007296 DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; cellular response to extracellular stimulus; cytosol; female pregnancy; in utero embryonic development; learning; negative regulation of cell proliferation; neuron projection; nucleus; placenta blood vessel development; positive regulation of apoptotic process; positive regulation of cell cycle; positive regulation of sequence-specific DNA binding transcription factor activity; presynaptic membrane; response to cAMP; response to corticosterone stimulus; response to cytokine stimulus; response to drug; response to gravity; response to hydrogen peroxide; response to mechanical stimulus; response to progesterone stimulus; sequence-specific DNA binding transcription factor activity; vitellogenesis IPR004827; IPR000837; Fos-related antigen 1 (FRA-1) Fosl1 Fra1 Rattus norvegicus (Rat) TR36877_c3_g1_i1 Q16206 ENOX2_HUMAN 2.00E-95 GO:0016049; GO:0005829; GO:0009897; GO:0005615; GO:0003676; GO:0000166; GO:0015035; GO:0040008; GO:0007624 cell growth; cytosol; external side of plasma membrane; extracellular space; nucleic acid binding; nucleotide binding; protein disulfide oxidoreductase activity; regulation of growth; ultradian rhythm IPR012677; IPR000504; Ecto-NOX disulfide-thiol exchanger 2 (APK1 antigen) (Cytosolic ovarian carcinoma antigen 1) (Tumor-associated hydroquinone oxidase) (tNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] ENOX2 COVA1 Homo sapiens (Human) TR36877_c3_g1_i2 Q8BHR2 ENOX1_MOUSE 3.00E-102 GO:0005615; GO:0003676; GO:0000166; GO:0016491; GO:0005886; GO:0048511 extracellular space; nucleic acid binding; nucleotide binding; oxidoreductase activity; plasma membrane; rhythmic process IPR012677; IPR000504; Ecto-NOX disulfide-thiol exchanger 1 (Constitutive Ecto-NOX) (cNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] Enox1 Mus musculus (Mouse) TR36877_c3_g1_i4 Q8BHR2 ENOX1_MOUSE 9.00E-75 GO:0005615; GO:0003676; GO:0000166; GO:0016491; GO:0005886; GO:0048511 extracellular space; nucleic acid binding; nucleotide binding; oxidoreductase activity; plasma membrane; rhythmic process IPR012677; IPR000504; Ecto-NOX disulfide-thiol exchanger 1 (Constitutive Ecto-NOX) (cNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] Enox1 Mus musculus (Mouse) TR36879_c4_g2_i1 Q8BM88 CATO_MOUSE 5.00E-68 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR000169; IPR025660; IPR013128; IPR000668; Cathepsin O (EC 3.4.22.42) Ctso Mus musculus (Mouse) TR36879_c5_g1_i1 Q497C3 CP013_RAT 2.00E-62 IPR010342; UPF0585 protein C16orf13 homolog Rattus norvegicus (Rat) TR36880_c3_g1_i1 Q9I930 FUCL2_ANGJA 1.00E-06 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-2 Anguilla japonica (Japanese eel) TR36880_c3_g1_i3 Q9I930 FUCL2_ANGJA 9.00E-07 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-2 Anguilla japonica (Japanese eel) TR36880_c3_g1_i5 P18503 CAS4_EPHMU 2.00E-07 GO:0005581 collagen IPR008160; Short-chain collagen C4 (Fragment) Ephydatia muelleri (Mueller's freshwater sponge) TR36881_c1_g1_i2 Q9LYK2 NRT27_ARATH 9.00E-45 GO:0016021; GO:0042128; GO:0015112; GO:0009705 integral to membrane; nitrate assimilation; nitrate transmembrane transporter activity; plant-type vacuole membrane IPR011701; IPR020846; IPR016196; High affinity nitrate transporter 2.7 (AtNRT2:7) NRT2.7 At5g14570 T15N1.60 Arabidopsis thaliana (Mouse-ear cress) TR36881_c1_g1_i5 Q9LPV5 NRT25_ARATH 3.00E-66 GO:0016021; GO:0042128; GO:0005886; GO:0055085 integral to membrane; nitrate assimilation; plasma membrane; transmembrane transport IPR011701; IPR016196; High affinity nitrate transporter 2.5 (AtNRT2:5) NRT2.5 At1g12940 F13K23.20 Arabidopsis thaliana (Mouse-ear cress) TR36881_c1_g1_i6 P22152 CRNA_EMENI 4.00E-52 GO:0016021; GO:0042128; GO:0015112; GO:0015513; GO:0022832 integral to membrane; nitrate assimilation; nitrate transmembrane transporter activity; nitrite uptake transmembrane transporter activity; voltage-gated channel activity IPR011701; IPR020846; IPR016196; IPR004737; Nitrate transporter (Nitrate permease) crnA AN1008 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR36882_c0_g1_i2 Q6PGE7 SC6A7_MOUSE 2.00E-99 GO:0006865; GO:0016021; GO:0005328 amino acid transport; integral to membrane; neurotransmitter:sodium symporter activity IPR000175; Sodium-dependent proline transporter (Solute carrier family 6 member 7) Slc6a7 Mus musculus (Mouse) TR36882_c0_g1_i4 A7Y2W8 SC6A9_XENLA 2.00E-140 GO:0005887; GO:0005328; GO:0005283 integral to plasma membrane; neurotransmitter:sodium symporter activity; sodium:amino acid symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9) slc6a9 glyt1 Xenopus laevis (African clawed frog) TR36882_c0_g1_i6 Q761V0 SC6A5_MOUSE 3.00E-118 GO:0016021; GO:0005328 integral to membrane; neurotransmitter:sodium symporter activity IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) Slc6a5 Glyt2 Mus musculus (Mouse) TR36883_c10_g1_i1 A0AUS0 WSDU1_DANRE 4.00E-128 GO:0000151; GO:0004842 ubiquitin ligase complex; ubiquitin-protein ligase activity IPR020472; IPR001660; IPR013761; IPR011510; IPR003613; IPR015943; IPR001680; IPR019775; IPR017986; IPR013083; "WD repeat, SAM and U-box domain-containing protein 1" wdsub1 zgc:154085 Danio rerio (Zebrafish) (Brachydanio rerio) TR36883_c10_g1_i2 Q5FVN8 WSDU1_RAT 8.00E-64 GO:0000151; GO:0004842 ubiquitin ligase complex; ubiquitin-protein ligase activity IPR020472; IPR001660; IPR013761; IPR011510; IPR003613; IPR015943; IPR001680; IPR019775; IPR017986; IPR013083; "WD repeat, SAM and U-box domain-containing protein 1" Wdsub1 Rattus norvegicus (Rat) TR36883_c10_g1_i3 Q0DR28 PUB57_ORYSJ 2.00E-17 GO:0005524; GO:0018108; GO:0004713; GO:0000151; GO:0004842 ATP binding; peptidyl-tyrosine phosphorylation; protein tyrosine kinase activity; ubiquitin ligase complex; ubiquitin-protein ligase activity IPR011009; IPR000719; IPR008266; IPR003613; IPR013083; Protein modification; protein ubiquitination. U-box domain-containing protein 57 (EC 6.3.2.-) (Plant U-box protein 57) (OsPUB57) PUB57 Os03g0424200 LOC_Os03g31070 Oryza sativa subsp. japonica (Rice) TR36884_c0_g1_i1 Q9CR16 PPID_MOUSE 1.00E-140 GO:0005528; GO:0030544; GO:0051879; GO:0006915; GO:0071492; GO:0061077; GO:0005737; GO:0030331; GO:0045111; GO:0034389; GO:0000122; GO:0005730; GO:0005654; GO:0042277; GO:0003755; GO:0043065; GO:0050714; GO:0045070; GO:0006461; GO:0015031; GO:0008134 FK506 binding; Hsp70 protein binding; Hsp90 protein binding; apoptotic process; cellular response to UV-A; chaperone-mediated protein folding; cytoplasm; estrogen receptor binding; intermediate filament cytoskeleton; lipid particle organization; negative regulation of transcription from RNA polymerase II promoter; nucleolus; nucleoplasm; peptide binding; peptidyl-prolyl cis-trans isomerase activity; positive regulation of apoptotic process; positive regulation of protein secretion; positive regulation of viral genome replication; protein complex assembly; protein transport; transcription factor binding IPR002130; IPR020892; IPR023114; IPR013026; IPR011990; IPR019734; Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Rotamase D) Ppid Mus musculus (Mouse) TR36884_c0_g1_i2 P52015 CYP7_CAEEL 9.00E-66 GO:0003755; GO:0006457; GO:0000413 peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase 7 (PPIase 7) (EC 5.2.1.8) (Cyclophilin-7) (Rotamase 7) cyn-7 cyp-7 Y75B12B.2 Caenorhabditis elegans TR36885_c1_g3_i2 Q9VTP4 R10AB_DROME 7.00E-80 GO:0003723; GO:0051298; GO:0015934; GO:0000022; GO:0003735; GO:0006412 RNA binding; centrosome duplication; large ribosomal subunit; mitotic spindle elongation; structural constituent of ribosome; translation IPR002143; IPR023674; IPR028364; IPR016094; IPR016095; 60S ribosomal protein L10a-2 RpL10Ab CG7283 Drosophila melanogaster (Fruit fly) TR36886_c1_g3_i1 P49442 INPP_MOUSE 1.00E-43 GO:0004441; GO:0046872; GO:0046854 "inositol-1,4-bisphosphate 1-phosphatase activity; metal ion binding; phosphatidylinositol phosphorylation" IPR020583; IPR000760; IPR020550; Signal transduction; phosphatidylinositol signaling pathway. Inositol polyphosphate 1-phosphatase (IPP) (IPPase) (EC 3.1.3.57) Inpp1 Mus musculus (Mouse) TR36886_c4_g1_i1 P49441 INPP_HUMAN 4.00E-25 GO:0005829; GO:0043647; GO:0052829; GO:0004441; GO:0046872; GO:0046854; GO:0007165 "cytosol; inositol phosphate metabolic process; inositol-1,3,4-trisphosphate 1-phosphatase activity; inositol-1,4-bisphosphate 1-phosphatase activity; metal ion binding; phosphatidylinositol phosphorylation; signal transduction" IPR020583; IPR000760; IPR020550; Signal transduction; phosphatidylinositol signaling pathway. Inositol polyphosphate 1-phosphatase (IPP) (IPPase) (EC 3.1.3.57) INPP1 Homo sapiens (Human) TR36886_c6_g1_i2 P35621 DVR1_DANRE 6.00E-09 GO:0005576; GO:0040007; GO:0051781 extracellular region; growth; positive regulation of cell division IPR001839; IPR001111; IPR015615; IPR017948; Protein DVR-1 dvr1 dvr-1 vg1 Danio rerio (Zebrafish) (Brachydanio rerio) TR36887_c0_g1_i1 Q3SZ90 RL13A_BOVIN 3.00E-86 GO:0015934; GO:1901194; GO:0017148; GO:0003735; GO:0006412 large ribosomal subunit; negative regulation of formation of translation preinitiation complex; negative regulation of translation; structural constituent of ribosome; translation IPR005822; IPR023563; IPR023564; IPR005755; 60S ribosomal protein L13a RPL13A Bos taurus (Bovine) TR36891_c0_g1_i1 Q3MHL7 TCPZ_BOVIN 0 GO:0005524; GO:0005737; GO:0006457 ATP binding; cytoplasm; protein folding IPR012722; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta) (CCT-zeta-1) CCT6A Bos taurus (Bovine) TR36892_c0_g1_i1 Q9H0R4 HDHD2_HUMAN 7.00E-116 GO:0046872 metal ion binding IPR023214; IPR006357; IPR006355; IPR023215; Haloacid dehalogenase-like hydrolase domain-containing protein 2 HDHD2 Homo sapiens (Human) TR36892_c0_g1_i2 A6NDG6 PGP_HUMAN 1.00E-08 GO:0005975; GO:0016311; GO:0008967 carbohydrate metabolic process; dephosphorylation; phosphoglycolate phosphatase activity IPR023214; IPR006357; IPR023215; IPR006349; Phosphoglycolate phosphatase (PGP) (PGPase) (EC 3.1.3.18) PGP Homo sapiens (Human) TR36892_c0_g1_i4 Q58832 Y1437_METJA 1.00E-07 GO:0016787 hydrolase activity IPR023214; IPR006439; IPR011950; Uncharacterized HAD-hydrolase MJ1437 (EC 3.-.-.-) MJ1437 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR36894_c2_g1_i1 Q8BQM9 MD12L_MOUSE 1.00E-59 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR019035; IPR021989; IPR021990; Mediator of RNA polymerase II transcription subunit 12-like protein (Mediator complex subunit 12-like protein) Med12l Kiaa3007 Mus musculus (Mouse) TR36894_c4_g1_i1 Q6TMG5 NEMO_RAT 6.00E-06 GO:0008385; GO:0042348; GO:0046872; GO:0005634; GO:0051092; GO:0045944; GO:0042803; GO:0006974; GO:0006351 "IkappaB kinase complex; NF-kappaB import into nucleus; metal ion binding; nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein homodimerization activity; response to DNA damage stimulus; transcription, DNA-dependent" IPR021063; NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) Ikbkg Nemo Rattus norvegicus (Rat) TR36894_c4_g3_i1 Q7YS99 OPTN_PIG 7.00E-11 GO:0005794; GO:0090161; GO:0043001; GO:0048471; GO:0000042; GO:0005802 Golgi apparatus; Golgi ribbon formation; Golgi to plasma membrane protein transport; perinuclear region of cytoplasm; protein targeting to Golgi; trans-Golgi network IPR021063; Optineurin OPTN Sus scrofa (Pig) TR36894_c4_g3_i2 Q5RI56 OPTN_DANRE 2.00E-18 GO:0005737 cytoplasm IPR021063; IPR015880; Optineurin optn si:ch211-240l19.3 zgc:66386 zgc:77868 Danio rerio (Zebrafish) (Brachydanio rerio) TR36894_c4_g4_i1 Q2QCI8 MED12_DANRE 1.00E-36 GO:0001104; GO:0048702; GO:0035118; GO:0048703; GO:0007492; GO:0030900; GO:0050935; GO:0001822; GO:0016592; GO:0030901; GO:0014032; GO:0030182; GO:0045893; GO:0002761; GO:0021654; GO:0003700 "RNA polymerase II transcription cofactor activity; embryonic neurocranium morphogenesis; embryonic pectoral fin morphogenesis; embryonic viscerocranium morphogenesis; endoderm development; forebrain development; iridophore differentiation; kidney development; mediator complex; midbrain development; neural crest cell development; neuron differentiation; positive regulation of transcription, DNA-dependent; regulation of myeloid leukocyte differentiation; rhombomere boundary formation; sequence-specific DNA binding transcription factor activity" IPR019035; IPR021989; IPR021990; Mediator of RNA polymerase II transcription subunit 12 (Mediator complex subunit 12) (Protein kohtalo) (Protein motionless) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) med12 kto mot trap230 Danio rerio (Zebrafish) (Brachydanio rerio) TR36894_c4_g7_i2 Q86YW9 MD12L_HUMAN 6.00E-177 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR019035; IPR021989; IPR021990; Mediator of RNA polymerase II transcription subunit 12-like protein (Mediator complex subunit 12-like protein) (Thyroid hormone receptor-associated-like protein) (Trinucleotide repeat-containing gene 11 protein-like) MED12L KIAA1635 TNRC11L TRALP TRALPUSH PRO0314 Homo sapiens (Human) TR36897_c0_g1_i2 Q8IZ73 RUSD2_HUMAN 3.00E-107 GO:0003723; GO:0009982; GO:0001522 RNA binding; pseudouridine synthase activity; pseudouridine synthesis IPR020103; IPR006225; IPR006224; IPR006145; RNA pseudouridylate synthase domain-containing protein 2 RPUSD2 C15orf19 Homo sapiens (Human) TR36897_c0_g1_i4 Q12069 PUS9_YEAST 7.00E-81 GO:0003723; GO:0005739; GO:0009982; GO:0031119 RNA binding; mitochondrion; pseudouridine synthase activity; tRNA pseudouridine synthesis IPR020103; IPR006225; IPR006224; IPR006145; IPR002942; "tRNA pseudouridine(32) synthase, mitochondrial (EC 5.4.99.28) (tRNA pseudouridine synthase 9) (tRNA pseudouridylate synthase 9) (tRNA-uridine isomerase 9)" PUS9 YDL036C D2743 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR36899_c0_g1_i1 Q41188 CSP2_ARATH 1.00E-09 GO:0032508; GO:0009631; GO:0005829; GO:0003690; GO:0003729; GO:0005730; GO:0005886; GO:0043457; GO:0006355; GO:0009737; GO:0009269; GO:0048316; GO:0003697; GO:0048443; GO:0010228; GO:0008270 "DNA duplex unwinding; cold acclimation; cytosol; double-stranded DNA binding; mRNA binding; nucleolus; plasma membrane; regulation of cellular respiration; regulation of transcription, DNA-dependent; response to abscisic acid stimulus; response to desiccation; seed development; single-stranded DNA binding; stamen development; vegetative to reproductive phase transition of meristem; zinc ion binding" IPR019844; IPR011129; IPR002059; IPR012340; IPR001878; Cold shock protein 2 (AtCSP2) (Cold shock domain-containing protein 2) (Glycine-rich protein 2) (AtGRP2) CSP2 CSDP2 GRP2 At4g38680 F20M13.240 Arabidopsis thaliana (Mouse-ear cress) TR36899_c0_g1_i2 Q9VRN5 LIN28_DROME 3.00E-42 GO:0003677; GO:0005737; GO:0006355; GO:0008270 "DNA binding; cytoplasm; regulation of transcription, DNA-dependent; zinc ion binding" IPR011129; IPR002059; IPR012340; IPR001878; Protein lin-28 homolog lin-28 CG17334 Drosophila melanogaster (Fruit fly) TR36899_c0_g1_i4 Q9VRN5 LIN28_DROME 8.00E-41 GO:0003677; GO:0005737; GO:0006355; GO:0008270 "DNA binding; cytoplasm; regulation of transcription, DNA-dependent; zinc ion binding" IPR011129; IPR002059; IPR012340; IPR001878; Protein lin-28 homolog lin-28 CG17334 Drosophila melanogaster (Fruit fly) TR36900_c1_g1_i1 Q9ESW8 PGPI_MOUSE 5.00E-66 GO:0008234; GO:0005829; GO:0008233; GO:0006508 cysteine-type peptidase activity; cytosol; peptidase activity; proteolysis IPR000816; IPR016125; Pyroglutamyl-peptidase 1 (EC 3.4.19.3) (5-oxoprolyl-peptidase) (Pyroglutamyl aminopeptidase I) (PAP-I) (Pyroglutamyl-peptidase I) (PGP-I) (Pyrrolidone-carboxylate peptidase) Pgpep1 Pgpi Mus musculus (Mouse) TR36901_c1_g1_i1 Q9VCA8 ANKHM_DROME 2.00E-13 GO:0003723; GO:0019730; GO:0051298; GO:0001751; GO:0005811; GO:0043066; GO:0046427; GO:0007169 RNA binding; antimicrobial humoral response; centrosome duplication; compound eye photoreceptor cell differentiation; lipid particle; negative regulation of apoptotic process; positive regulation of JAK-STAT cascade; transmembrane receptor protein tyrosine kinase signaling pathway IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) TR36902_c2_g4_i2 P51688 SPHM_HUMAN 3.00E-126 GO:0016250; GO:0005975; GO:0003824; GO:0006027; GO:0043202; GO:0046872; GO:0006029; GO:0044281; GO:0008484 N-sulfoglucosamine sulfohydrolase activity; carbohydrate metabolic process; catalytic activity; glycosaminoglycan catabolic process; lysosomal lumen; metal ion binding; proteoglycan metabolic process; small molecule metabolic process; sulfuric ester hydrolase activity IPR017849; IPR017850; IPR000917; IPR024607; N-sulphoglucosamine sulphohydrolase (EC 3.10.1.1) (Sulfoglucosamine sulfamidase) (Sulphamidase) SGSH HSS Homo sapiens (Human) TR36902_c2_g4_i4 P51688 SPHM_HUMAN 1.00E-132 GO:0016250; GO:0005975; GO:0003824; GO:0006027; GO:0043202; GO:0046872; GO:0006029; GO:0044281; GO:0008484 N-sulfoglucosamine sulfohydrolase activity; carbohydrate metabolic process; catalytic activity; glycosaminoglycan catabolic process; lysosomal lumen; metal ion binding; proteoglycan metabolic process; small molecule metabolic process; sulfuric ester hydrolase activity IPR017849; IPR017850; IPR000917; IPR024607; N-sulphoglucosamine sulphohydrolase (EC 3.10.1.1) (Sulfoglucosamine sulfamidase) (Sulphamidase) SGSH HSS Homo sapiens (Human) TR36904_c2_g1_i1 Q02977 YRK_CHICK 4.00E-115 GO:0005524; GO:0004715; GO:0018108 ATP binding; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2) (Yes-related kinase) (p60-Yrk) YRK Gallus gallus (Chicken) TR36904_c2_g1_i2 Q9D241 RN186_MOUSE 7.00E-07 GO:0016021; GO:0008270 integral to membrane; zinc ion binding IPR001841; IPR013083; IPR017907; RING finger protein 186 Rnf186 Mus musculus (Mouse) TR36904_c2_g1_i3 Q8QHL3 VGFR1_CHICK 3.00E-29 GO:0005524; GO:0001525; GO:0030154; GO:0006935; GO:0005768; GO:0005576; GO:0005887; GO:0018108; GO:0048010; GO:0038084; GO:0005021 ATP binding; angiogenesis; cell differentiation; chemotaxis; endosome; extracellular region; integral to plasma membrane; peptidyl-tyrosine phosphorylation; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor signaling pathway; vascular endothelial growth factor-activated receptor activity IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR001824; IPR009135; Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) FLT1 VEGFR1 Gallus gallus (Chicken) TR36904_c2_g1_i4 P06241 FYN_HUMAN 2.00E-118 GO:0005524; GO:0038095; GO:0038096; GO:0031295; GO:0050852; GO:0050798; GO:0007411; GO:0006816; GO:0071375; GO:0005829; GO:0048813; GO:0050966; GO:0005768; GO:0007173; GO:0007631; GO:0008543; GO:0030900; GO:0045087; GO:0007243; GO:0007612; GO:0050900; GO:0046872; GO:0005739; GO:0019048; GO:2001240; GO:0010629; GO:0042177; GO:0001764; GO:0048011; GO:0004715; GO:0005634; GO:0048015; GO:0005886; GO:0030168; GO:0010976; GO:0014069; GO:0046777; GO:0008360; GO:0050690; GO:0042493; GO:0045471; GO:0016032 O92972; P27958; Q9WMX2; P42684; Q13444; A7KAX9; O14559; Q9ULH1; P56945; P02751-7; O15117; P08238; P50406; Q07666; Q92918; Q9H204; Q8WX92; Q9NWQ8; Q8WUM4; P09619; O43900; Q05655; Q04759; Q13905; O60880 ATP binding; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; T cell costimulation; T cell receptor signaling pathway; activated T cell proliferation; axon guidance; calcium ion transport; cellular response to peptide hormone stimulus; cytosol; dendrite morphogenesis; detection of mechanical stimulus involved in sensory perception of pain; endosome; epidermal growth factor receptor signaling pathway; feeding behavior; fibroblast growth factor receptor signaling pathway; forebrain development; innate immune response; intracellular protein kinase cascade; learning; leukocyte migration; metal ion binding; mitochondrion; modulation by virus of host morphology or physiology; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of gene expression; negative regulation of protein catabolic process; neuron migration; neurotrophin TRK receptor signaling pathway; non-membrane spanning protein tyrosine kinase activity; nucleus; phosphatidylinositol-mediated signaling; plasma membrane; platelet activation; positive regulation of neuron projection development; postsynaptic density; protein autophosphorylation; regulation of cell shape; regulation of defense response to virus by virus; response to drug; response to ethanol; viral process IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) FYN Homo sapiens (Human) TR36905_c0_g1_i1 O14088 YER5_SCHPO 4.00E-29 GO:0042843; GO:0032866; GO:0032867; GO:0019568; GO:0005829; GO:0005634 D-xylose catabolic process; D-xylose:NADP reductase activity; L-arabinose:NADP reductase activity; arabinose catabolic process; cytosol; nucleus IPR001395; IPR018170; IPR020471; IPR023210; Uncharacterized oxidoreductase C2F3.05c (EC 1.-.-.-) SPAC2F3.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36905_c0_g1_i2 Q09632 YOF5_CAEEL 2.00E-28 GO:0016491 oxidoreductase activity IPR001395; IPR018170; IPR020471; IPR023210; Uncharacterized oxidoreductase ZK1290.5 (EC 1.-.-.-) ZK1290.5 Caenorhabditis elegans TR36905_c0_g2_i2 A1T726 Y2161_MYCVP 6.00E-45 GO:0016491 oxidoreductase activity IPR001395; IPR018170; IPR020471; IPR023210; Uncharacterized oxidoreductase Mvan_2161 (EC 1.-.-.-) Mvan_2161 Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1) TR36905_c0_g2_i5 Q9GV41 PGFS_TRYBB 6.00E-47 GO:0005737; GO:0000166; GO:0036131; GO:0001516; GO:0047017 cytoplasm; nucleotide binding; prostaglandin D2 11-ketoreductase activity; prostaglandin biosynthetic process; prostaglandin-F synthase activity IPR001395; IPR018170; IPR020471; IPR023210; Lipid metabolism; prostaglandin biosynthesis. Prostaglandin F synthase (EC 1.1.1.188) (Prostaglandin F2-alpha synthase) Trypanosoma brucei brucei TR36910_c3_g1_i1 Q5QJE6 TDIF2_HUMAN 1.00E-40 GO:0005730; GO:0006355; GO:0006351 "nucleolus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR014810; Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) DNTTIP2 ERBP TDIF2 Homo sapiens (Human) TR36911_c1_g2_i3 Q8N0W4 NLGNX_HUMAN 2.00E-73 GO:0003360; GO:0007155; GO:0030054; GO:0009986; GO:0045216; GO:0021549; GO:0031404; GO:0030425; GO:0060076; GO:0005887; GO:0090394; GO:0042043; GO:0035265; GO:0014069; GO:0045211; GO:0097105; GO:0042803; GO:0004872; GO:0035176; GO:0071625 Q63373 brainstem development; cell adhesion; cell junction; cell surface; cell-cell junction organization; cerebellum development; chloride ion binding; dendrite; excitatory synapse; integral to plasma membrane; negative regulation of excitatory postsynaptic membrane potential; neurexin family protein binding; organ growth; postsynaptic density; postsynaptic membrane; presynaptic membrane assembly; protein homodimerization activity; receptor activity; social behavior; vocalization behavior IPR002018; IPR019819; IPR000460; "Neuroligin-4, X-linked (Neuroligin X) (HNLX)" NLGN4X KIAA1260 NLGN4 UNQ365/PRO701 Homo sapiens (Human) TR36911_c1_g2_i5 Q8N0W4 NLGNX_HUMAN 7.00E-75 GO:0003360; GO:0007155; GO:0030054; GO:0009986; GO:0045216; GO:0021549; GO:0031404; GO:0030425; GO:0060076; GO:0005887; GO:0090394; GO:0042043; GO:0035265; GO:0014069; GO:0045211; GO:0097105; GO:0042803; GO:0004872; GO:0035176; GO:0071625 Q63373 brainstem development; cell adhesion; cell junction; cell surface; cell-cell junction organization; cerebellum development; chloride ion binding; dendrite; excitatory synapse; integral to plasma membrane; negative regulation of excitatory postsynaptic membrane potential; neurexin family protein binding; organ growth; postsynaptic density; postsynaptic membrane; presynaptic membrane assembly; protein homodimerization activity; receptor activity; social behavior; vocalization behavior IPR002018; IPR019819; IPR000460; "Neuroligin-4, X-linked (Neuroligin X) (HNLX)" NLGN4X KIAA1260 NLGN4 UNQ365/PRO701 Homo sapiens (Human) TR36911_c1_g2_i6 Q8I034 EST5A_FELCA 4.00E-40 GO:0004091; GO:0005576 carboxylesterase activity; extracellular region IPR002018; IPR019826; IPR019819; Carboxylesterase 5A (EC 3.1.1.1) (Carboxylesterase-like urinary excreted protein) (Cauxin) CES5A CES7 Felis catus (Cat) (Felis silvestris catus) TR36911_c1_g2_i7 Q62889 NLGN3_RAT 4.00E-60 GO:0048675; GO:0030054; GO:0009986; GO:0030139; GO:0060076; GO:0060077; GO:0005887; GO:0042043; GO:0007158; GO:2000969; GO:2000463; GO:0051965; GO:0051968; GO:0097104; GO:0097105; GO:0004872; GO:0006898; GO:2000310; GO:0061001; GO:0060080; GO:1900271; GO:0002087; GO:2000331; GO:0060024; GO:0035176 "axon extension; cell junction; cell surface; endocytic vesicle; excitatory synapse; inhibitory synapse; integral to plasma membrane; neurexin family protein binding; neuron cell-cell adhesion; positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; positive regulation of excitatory postsynaptic membrane potential; positive regulation of synapse assembly; positive regulation of synaptic transmission, glutamatergic; postsynaptic membrane assembly; presynaptic membrane assembly; receptor activity; receptor-mediated endocytosis; regulation of N-methyl-D-aspartate selective glutamate receptor activity; regulation of dendritic spine morphogenesis; regulation of inhibitory postsynaptic membrane potential; regulation of long-term synaptic potentiation; regulation of respiratory gaseous exchange by neurological system process; regulation of terminal button organization; rhythmic synaptic transmission; social behavior" IPR002018; IPR019819; IPR000460; Neuroligin-3 (Gliotactin homolog) Nlgn3 Rattus norvegicus (Rat) TR36911_c1_g2_i8 B0F2B4 NLGN4_MOUSE 1.00E-51 GO:0003360; GO:0030054; GO:0009986; GO:0021549; GO:0030425; GO:0060076; GO:0005887; GO:0008049; GO:0090394; GO:0042043; GO:0035265; GO:0045211; GO:0097105; GO:0004872; GO:0035176; GO:0002124; GO:0071625 brainstem development; cell junction; cell surface; cerebellum development; dendrite; excitatory synapse; integral to plasma membrane; male courtship behavior; negative regulation of excitatory postsynaptic membrane potential; neurexin family protein binding; organ growth; postsynaptic membrane; presynaptic membrane assembly; receptor activity; social behavior; territorial aggressive behavior; vocalization behavior IPR002018; IPR019819; Neuroligin 4-like (Neuroligin-4) (NL-4) Nlgn4l Nl4* Nlgn4 Nlgn4x Mus musculus (Mouse) TR36911_c1_g3_i1 Q8WMH2 NLGN3_MACMU 2.00E-31 GO:0007155; GO:0030054; GO:0009986; GO:0005887; GO:0042043; GO:0004872; GO:0045202; GO:0007416 cell adhesion; cell junction; cell surface; integral to plasma membrane; neurexin family protein binding; receptor activity; synapse; synapse assembly IPR002018; IPR000460; Neuroligin-3 (Gliotactin homolog) (Fragment) NLGN3 Macaca mulatta (Rhesus macaque) TR36913_c0_g1_i1 Q337A0 XB33_ORYSJ 3.00E-07 GO:0016874; GO:0016567; GO:0008270 ligase activity; protein ubiquitination; zinc ion binding IPR002110; IPR020683; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase XBOS33 (EC 6.3.2.-) (Ankyrin repeat domain and RING finger-containing protein XBOS33) (XB3 protein homolog 3) XBOS33 Os10g0521600 LOC_Os10g37730 OSJNBb0018B10.26 OSJNBb0028C01.29 Oryza sativa subsp. japonica (Rice) TR36913_c0_g1_i2 Q8C8R3 ANK2_MOUSE 4.00E-07 GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005887; GO:0014704; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086015; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307 "M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; integral to plasma membrane; intercalated disc; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of SA node cell action potential; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Brain ankyrin) Ank2 Mus musculus (Mouse) TR36913_c0_g1_i3 Q94A76 GORK_ARATH 9.00E-07 GO:0016021; GO:0005634; GO:0015271; GO:0009737; GO:0009409; GO:0009753; GO:0009414 integral to membrane; nucleus; outward rectifier potassium channel activity; response to abscisic acid stimulus; response to cold; response to jasmonic acid stimulus; response to water deprivation IPR002110; IPR020683; IPR018490; IPR000595; IPR005821; IPR021789; IPR003938; IPR014710; Potassium channel GORK (Guard cell outward rectifying K(+) channel) (AtGORK) GORK At5g37500 MPA22.4 Arabidopsis thaliana (Mouse-ear cress) TR36913_c0_g1_i4 Q8BTI7 ANR52_MOUSE 7.00E-07 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) Ankrd52 Mus musculus (Mouse) TR36913_c0_g2_i1 Q6PFX9 TNKS1_MOUSE 3.00E-11 GO:0005794; GO:0000139; GO:0003950; GO:0016055; GO:0051301; GO:0000775; GO:0051028; GO:0007067; GO:0043392; GO:0000784; GO:0005643; GO:0018105; GO:0018107; GO:0090263; GO:0032212; GO:0045944; GO:0070213; GO:0070198; GO:0070212; GO:0000209; GO:0015031; GO:0000922; GO:0008270 "Golgi apparatus; Golgi membrane; NAD+ ADP-ribosyltransferase activity; Wnt receptor signaling pathway; cell division; chromosome, centromeric region; mRNA transport; mitosis; negative regulation of DNA binding; nuclear chromosome, telomeric region; nuclear pore; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of telomere maintenance via telomerase; positive regulation of transcription from RNA polymerase II promoter; protein auto-ADP-ribosylation; protein localization to chromosome, telomeric region; protein poly-ADP-ribosylation; protein polyubiquitination; protein transport; spindle pole; zinc ion binding" IPR002110; IPR020683; IPR012317; IPR001660; IPR013761; IPR011510; Tankyrase-1 (TANK1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (TRF1-interacting ankyrin-related ADP-ribose polymerase 1) (Tankyrase I) Tnks Tnks1 Mus musculus (Mouse) TR36913_c0_g2_i2 Q2QLG9 CTTB2_OTOGA 1.00E-13 GO:0005938; GO:0043197 cell cortex; dendritic spine IPR002110; IPR020683; IPR019131; Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) TR36913_c0_g2_i4 Q01484 ANK2_HUMAN 1.00E-13 GO:0051117; GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0007411; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005829; GO:0005887; GO:0014704; GO:0044325; GO:0086046; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307; GO:0070296 P11532-5; P62993 "ATPase binding; M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; axon guidance; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; cytosol; integral to plasma membrane; intercalated disc; ion channel binding; membrane depolarization involved in regulation of SA node cell action potential; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization; sarcoplasmic reticulum calcium ion transport" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) TR36914_c0_g1_i3 Q9NVM9 ASUN_HUMAN 0 GO:0051301; GO:0005737; GO:0007067; GO:0005634; GO:0080154; GO:0007346; GO:0030317 Q13951 cell division; cytoplasm; mitosis; nucleus; regulation of fertilization; regulation of mitotic cell cycle; sperm motility IPR019355; Protein asunder homolog (Cell cycle regulator Mat89Bb homolog) (Germ cell tumor 1) (Sarcoma antigen NY-SAR-95) ASUN C12orf11 GCT1 Homo sapiens (Human) TR36915_c0_g1_i1 Q3UMT1 PP12C_MOUSE 3.00E-20 GO:0005737 cytoplasm IPR002110; IPR020683; IPR017401; Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) Ppp1r12c Mbs85 Mus musculus (Mouse) TR36915_c0_g2_i1 Q96T49 PP16B_HUMAN 2.00E-53 GO:0005634; GO:0005886; GO:0019903; GO:0051489; GO:0007165 nucleus; plasma membrane; protein phosphatase binding; regulation of filopodium assembly; signal transduction IPR002110; IPR020683; IPR017417; Protein phosphatase 1 regulatory inhibitor subunit 16B (Ankyrin repeat domain-containing protein 4) (CAAX box protein TIMAP) (TGF-beta-inhibited membrane-associated protein) (hTIMAP) PPP1R16B ANKRD4 KIAA0823 Homo sapiens (Human) TR36917_c0_g1_i1 Q52KZ7 SBP1A_XENLA 0 GO:0005829; GO:0016020; GO:0005634; GO:0015031; GO:0008430 cytosol; membrane; nucleus; protein transport; selenium binding IPR008826; IPR015943; Selenium-binding protein 1-A selenbp1-a Xenopus laevis (African clawed frog) TR36917_c0_g1_i2 Q52KZ7 SBP1A_XENLA 0 GO:0005829; GO:0016020; GO:0005634; GO:0015031; GO:0008430 cytosol; membrane; nucleus; protein transport; selenium binding IPR008826; IPR015943; Selenium-binding protein 1-A selenbp1-a Xenopus laevis (African clawed frog) TR36918_c4_g1_i1 Q5M807 RNF5_RAT 2.00E-41 GO:0071712; GO:0005789; GO:0016021; GO:0031966; GO:0070936; GO:0070534; GO:0004842; GO:0008270 ER-associated misfolded protein catabolic process; endoplasmic reticulum membrane; integral to membrane; mitochondrial membrane; protein K48-linked ubiquitination; protein K63-linked ubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF5 (EC 6.3.2.-) (RING finger protein 5) Rnf5 Rattus norvegicus (Rat) TR36918_c4_g1_i2 Q91YT2 RN185_MOUSE 5.00E-61 GO:0006914; GO:0016021; GO:0016874; GO:0005741; GO:0016567; GO:0008270 autophagy; integral to membrane; ligase activity; mitochondrial outer membrane; protein ubiquitination; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF185 (EC 6.3.2.-) (RING finger protein 185) Rnf185 Mus musculus (Mouse) TR3692_c0_g1_i1 Q22RG7 H34_TETTS 4.00E-10 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR000164; Histone H3.4 (Minor histone H3 variant) HHT4 TTHERM_00016200 Tetrahymena thermophila (strain SB210) TR36922_c1_g1_i1 P78317 RNF4_HUMAN 1.00E-15 GO:0003677; GO:0016605; GO:0032184; GO:0050681; GO:0030521; GO:0005737; GO:0015630; GO:0031491; GO:0005634; GO:0045944; GO:0043161; GO:0070979; GO:0070936; GO:0085020; GO:0070534; GO:0051865; GO:0090234; GO:0090169; GO:0046685; GO:0003700; GO:0003713; GO:0006351; GO:0004842; GO:0008270 "DNA binding; PML body; SUMO polymer binding; androgen receptor binding; androgen receptor signaling pathway; cytoplasm; microtubule cytoskeleton; nucleosome binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; protein K11-linked ubiquitination; protein K48-linked ubiquitination; protein K6-linked ubiquitination; protein K63-linked ubiquitination; protein autoubiquitination; regulation of kinetochore assembly; regulation of spindle assembly; response to arsenic-containing substance; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF4 (EC 6.3.2.-) (RING finger protein 4) (Small nuclear ring finger protein) (Protein SNURF) RNF4 SNURF RES4-26 Homo sapiens (Human) TR36922_c4_g5_i2 A6NMZ7 CO6A6_HUMAN 2.00E-34 GO:0007155; GO:0005581; GO:0030574; GO:0031012; GO:0022617; GO:0005576 cell adhesion; collagen; collagen catabolic process; extracellular matrix; extracellular matrix disassembly; extracellular region IPR008160; IPR002035; Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) TR36923_c5_g1_i1 Q1PSW8 LIN41_MOUSE 1.00E-10 GO:0000082; GO:0000932; GO:0008543; GO:0035198; GO:0010586; GO:0035278; GO:0001843; GO:2000637; GO:0051865; GO:2000177; GO:0072089; GO:0004842; GO:0008270 G1/S transition of mitotic cell cycle; cytoplasmic mRNA processing body; fibroblast growth factor receptor signaling pathway; miRNA binding; miRNA metabolic process; negative regulation of translation involved in gene silencing by miRNA; neural tube closure; positive regulation of gene silencing by miRNA; protein autoubiquitination; regulation of neural precursor cell proliferation; stem cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (mLin41) (Tripartite motif-containing protein 71) Trim71 Gm1127 Lin41 Mus musculus (Mouse) TR36923_c5_g1_i3 Q1PRL4 LIN41_CHICK 2.00E-14 GO:0000082; GO:0000932; GO:0008543; GO:0035198; GO:0010586; GO:0035278; GO:0001843; GO:0021915; GO:2000637; GO:0051865; GO:0060964; GO:2000177; GO:0072089; GO:0004842; GO:0008270 G1/S transition of mitotic cell cycle; cytoplasmic mRNA processing body; fibroblast growth factor receptor signaling pathway; miRNA binding; miRNA metabolic process; negative regulation of translation involved in gene silencing by miRNA; neural tube closure; neural tube development; positive regulation of gene silencing by miRNA; protein autoubiquitination; regulation of gene silencing by miRNA; regulation of neural precursor cell proliferation; stem cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Gallus gallus (Chicken) TR36925_c0_g2_i1 Q6E2N3 TRI33_DANRE 4.00E-09 GO:0003677; GO:0016874; GO:0005634; GO:0016567; GO:0006355; GO:0006351; GO:0008270 "DNA binding; ligase activity; nucleus; protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (Protein moonshine) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 mon Danio rerio (Zebrafish) (Brachydanio rerio) TR36926_c1_g1_i1 Q6WCQ1 MPRIP_HUMAN 3.00E-11 GO:0005737; GO:0005856; GO:0005543 Q10728 cytoplasm; cytoskeleton; phospholipid binding IPR011993; IPR001849; Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) MPRIP KIAA0864 MRIP RHOIP3 Homo sapiens (Human) TR36927_c2_g8_i1 Q9CTY5 EFHA2_MOUSE 3.00E-20 GO:0005509; GO:0016021; GO:0005739 calcium ion binding; integral to membrane; mitochondrion IPR011992; IPR018247; IPR002048; "Calcium uptake protein 3, mitochondrial (EF-hand domain-containing family member A2)" Micu3 Efha2 Mus musculus (Mouse) TR36927_c2_g8_i2 B1H2N3 MICU1_XENTR 1.00E-114 GO:0005509; GO:0070509; GO:0032592; GO:0051560; GO:0006851; GO:0005743 calcium ion binding; calcium ion import; integral to mitochondrial membrane; mitochondrial calcium ion homeostasis; mitochondrial calcium ion transport; mitochondrial inner membrane IPR011992; IPR018247; IPR002048; "Calcium uptake protein 1, mitochondrial (Calcium-binding atopy-related autoantigen 1 homolog)" micu1 cbara1 TGas034p18.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36927_c2_g8_i5 Q9QXX4 CMC2_MOUSE 4.00E-08 GO:0015183; GO:0005313; GO:0005509; GO:0016021; GO:0043490; GO:0005743; GO:0051592 L-aspartate transmembrane transporter activity; L-glutamate transmembrane transporter activity; calcium ion binding; integral to membrane; malate-aspartate shuttle; mitochondrial inner membrane; response to calcium ion IPR011992; IPR002048; IPR002067; IPR018108; IPR023395; Calcium-binding mitochondrial carrier protein Aralar2 (Citrin) (Mitochondrial aspartate glutamate carrier 2) (Solute carrier family 25 member 13) Slc25a13 Aralar2 Mus musculus (Mouse) TR36927_c2_g8_i6 B1H2N3 MICU1_XENTR 2.00E-102 GO:0005509; GO:0070509; GO:0032592; GO:0051560; GO:0006851; GO:0005743 calcium ion binding; calcium ion import; integral to mitochondrial membrane; mitochondrial calcium ion homeostasis; mitochondrial calcium ion transport; mitochondrial inner membrane IPR011992; IPR018247; IPR002048; "Calcium uptake protein 1, mitochondrial (Calcium-binding atopy-related autoantigen 1 homolog)" micu1 cbara1 TGas034p18.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36927_c2_g8_i7 Q9CTY5 EFHA2_MOUSE 2.00E-21 GO:0005509; GO:0016021; GO:0005739 calcium ion binding; integral to membrane; mitochondrion IPR011992; IPR018247; IPR002048; "Calcium uptake protein 3, mitochondrial (EF-hand domain-containing family member A2)" Micu3 Efha2 Mus musculus (Mouse) TR36929_c5_g3_i2 Q2S2F5 KYNB_SALRD 4.00E-08 GO:0043420; GO:0004061; GO:0004328; GO:0019441 anthranilate metabolic process; arylformamidase activity; formamidase activity; tryptophan catabolic process to kynurenine IPR007325; IPR017484; Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. Kynurenine formamidase (KFA) (KFase) (EC 3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF) kynB SRU_1503 Salinibacter ruber (strain DSM 13855 / M31) TR36929_c6_g1_i1 P77475 YQAB_ECOLI 2.00E-14 GO:0008801; GO:0000287; GO:0016791 P50456 beta-phosphoglucomutase activity; magnesium ion binding; phosphatase activity IPR010976; IPR023214; IPR006439; Fructose-1-phosphate phosphatase YqaB (EC 3.1.3.-) (Fructose-1-phosphatase) yqaB b2690 JW2665 Escherichia coli (strain K12) TR36929_c6_g1_i2 O59760 YJM7_SCHPO 7.00E-38 GO:0005829; GO:0016787; GO:0005634 cytosol; hydrolase activity; nucleus IPR023214; IPR006439; Putative uncharacterized hydrolase C1020.07 (EC 3.-.-.-) SPCC1020.07 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36929_c6_g1_i3 Q08623 HDHD1_HUMAN 2.00E-78 GO:0016311; GO:0046872; GO:0009117; GO:0016791 dephosphorylation; metal ion binding; nucleotide metabolic process; phosphatase activity IPR023214; IPR006439; Pseudouridine-5'-monophosphatase (5'-PsiMPase) (EC 3.1.3.n6) (Haloacid dehalogenase-like hydrolase domain-containing protein 1) (Haloacid dehalogenase-like hydrolase domain-containing protein 1A) (Protein GS1) HDHD1 DXF68S1E FAM16AX GS1 HDHD1A Homo sapiens (Human) TR36929_c6_g1_i5 Q94529 GS1_DROME 1.00E-63 GO:0016311; GO:0046872; GO:0009117; GO:0016791; GO:0042060 dephosphorylation; metal ion binding; nucleotide metabolic process; phosphatase activity; wound healing IPR023214; IPR006439; Probable pseudouridine-5'-monophosphatase (5'-PsiMPase) (EC 3.1.3.n6) (GS1-like protein) Gs1l CG15441 Drosophila melanogaster (Fruit fly) TR36929_c6_g1_i7 Q08623 HDHD1_HUMAN 6.00E-76 GO:0016311; GO:0046872; GO:0009117; GO:0016791 dephosphorylation; metal ion binding; nucleotide metabolic process; phosphatase activity IPR023214; IPR006439; Pseudouridine-5'-monophosphatase (5'-PsiMPase) (EC 3.1.3.n6) (Haloacid dehalogenase-like hydrolase domain-containing protein 1) (Haloacid dehalogenase-like hydrolase domain-containing protein 1A) (Protein GS1) HDHD1 DXF68S1E FAM16AX GS1 HDHD1A Homo sapiens (Human) TR36930_c0_g1_i1 P62264 RS14_MOUSE 2.00E-83 GO:0003723; GO:0022627; GO:0030218; GO:0048027; GO:0030490; GO:0005739; GO:0000122; GO:0005730; GO:0000028; GO:0003735; GO:0006412; GO:0045182 RNA binding; cytosolic small ribosomal subunit; erythrocyte differentiation; mRNA 5'-UTR binding; maturation of SSU-rRNA; mitochondrion; negative regulation of transcription from RNA polymerase II promoter; nucleolus; ribosomal small subunit assembly; structural constituent of ribosome; translation; translation regulator activity IPR001971; IPR018102; 40S ribosomal protein S14 Rps14 Mus musculus (Mouse) TR36932_c0_g2_i2 Q9VSD7 DBR1_DROME 2.00E-136 GO:0008419; GO:0000375; GO:0006397; GO:0005634 Q9VEA9 "RNA lariat debranching enzyme activity; RNA splicing, via transesterification reactions; mRNA processing; nucleus" IPR007708; IPR004843; Lariat debranching enzyme (DmDBR1) (EC 3.1.-.-) ldbr DBR1 CG7942 Drosophila melanogaster (Fruit fly) TR36932_c0_g2_i3 O13765 DBR1_SCHPO 5.00E-86 GO:0008419; GO:0031070; GO:0045292; GO:0005634 "RNA lariat debranching enzyme activity; intronic snoRNA processing; mRNA cis splicing, via spliceosome; nucleus" IPR007708; IPR004843; Lariat debranching enzyme (EC 3.1.-.-) dbr1 SPAC17A5.02c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36932_c0_g2_i4 Q6GPB8 DBR1A_XENLA 4.00E-157 GO:0008419; GO:0000375; GO:0006397; GO:0005634 "RNA lariat debranching enzyme activity; RNA splicing, via transesterification reactions; mRNA processing; nucleus" IPR007708; IPR004843; Lariat debranching enzyme A (EC 3.1.-.-) dbr1-a Xenopus laevis (African clawed frog) TR36932_c0_g2_i6 P24309 DBR1_YEAST 2.00E-68 GO:0006401; GO:0008419; GO:0005737; GO:0006397; GO:0005634; GO:0007124; GO:0016074; GO:0032197 "RNA catabolic process; RNA lariat debranching enzyme activity; cytoplasm; mRNA processing; nucleus; pseudohyphal growth; snoRNA metabolic process; transposition, RNA-mediated" IPR007708; IPR004843; Lariat debranching enzyme (EC 3.1.-.-) DBR1 PRP26 YKL149C YKL604 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR36933_c1_g1_i2 Q5T8I3 F102B_HUMAN 3.00E-74 IPR019448; Protein FAM102B FAM102B Homo sapiens (Human) TR36934_c0_g1_i3 Q99715 COCA1_HUMAN 1.00E-10 GO:0007155; GO:0030574; GO:0030199; GO:0005595; GO:0005788; GO:0022617; GO:0030020; GO:0005615; GO:0070062; GO:0001501 cell adhesion; collagen catabolic process; collagen fibril organization; collagen type XII; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular matrix structural constituent conferring tensile strength; extracellular space; extracellular vesicular exosome; skeletal system development IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) TR36935_c3_g1_i1 Q9UBN7 HDAC6_HUMAN 2.00E-36 GO:0070846; GO:0051879; GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0016235; GO:0070842; GO:0043014; GO:0005901; GO:0031252; GO:0070301; GO:0071218; GO:0035967; GO:0005881; GO:0005829; GO:0070840; GO:0019899; GO:0070932; GO:0070933; GO:0004407; GO:0000118; GO:0032418; GO:0016236; GO:0005874; GO:0005875; GO:0008017; GO:0006515; GO:0010727; GO:0007026; GO:0051354; GO:0043242; GO:0045861; GO:0045892; GO:0034983; GO:0048471; GO:0031593; GO:0070845; GO:0090035; GO:0010634; GO:1901300; GO:0010870; GO:0009967; GO:0043241; GO:0000209; GO:0060765; GO:0070201; GO:0060632; GO:0010469; GO:0070848; GO:0051788; GO:0009636; GO:0048156; GO:0006351; GO:0042903; GO:0043162; GO:0008270 P21146; Q9NQ11; Q9HCU9; Q62623; Q14247; Q60598; Q9NQC7; P00533; P17252; P03409 "Hsp90 deacetylation; Hsp90 protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); aggresome; aggresome assembly; alpha-tubulin binding; caveola; cell leading edge; cellular response to hydrogen peroxide; cellular response to misfolded protein; cellular response to topologically incorrect protein; cytoplasmic microtubule; cytosol; dynein complex binding; enzyme binding; histone H3 deacetylation; histone H4 deacetylation; histone deacetylase activity; histone deacetylase complex; lysosome localization; macroautophagy; microtubule; microtubule associated complex; microtubule binding; misfolded or incompletely synthesized protein catabolic process; negative regulation of hydrogen peroxide metabolic process; negative regulation of microtubule depolymerization; negative regulation of oxidoreductase activity; negative regulation of protein complex disassembly; negative regulation of proteolysis; negative regulation of transcription, DNA-dependent; peptidyl-lysine deacetylation; perinuclear region of cytoplasm; polyubiquitin binding; polyubiquitinated misfolded protein transport; positive regulation of chaperone-mediated protein complex assembly; positive regulation of epithelial cell migration; positive regulation of hydrogen peroxide-mediated programmed cell death; positive regulation of receptor biosynthetic process; positive regulation of signal transduction; protein complex disassembly; protein polyubiquitination; regulation of androgen receptor signaling pathway; regulation of establishment of protein localization; regulation of microtubule-based movement; regulation of receptor activity; response to growth factor stimulus; response to misfolded protein; response to toxic substance; tau protein binding; transcription, DNA-dependent; tubulin deacetylase activity; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; zinc ion binding" IPR000286; IPR023801; IPR013083; IPR001607; Histone deacetylase 6 (HD6) (EC 3.5.1.98) HDAC6 KIAA0901 JM21 Homo sapiens (Human) TR36935_c4_g1_i1 Q9UBN7 HDAC6_HUMAN 2.00E-133 GO:0070846; GO:0051879; GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0016235; GO:0070842; GO:0043014; GO:0005901; GO:0031252; GO:0070301; GO:0071218; GO:0035967; GO:0005881; GO:0005829; GO:0070840; GO:0019899; GO:0070932; GO:0070933; GO:0004407; GO:0000118; GO:0032418; GO:0016236; GO:0005874; GO:0005875; GO:0008017; GO:0006515; GO:0010727; GO:0007026; GO:0051354; GO:0043242; GO:0045861; GO:0045892; GO:0034983; GO:0048471; GO:0031593; GO:0070845; GO:0090035; GO:0010634; GO:1901300; GO:0010870; GO:0009967; GO:0043241; GO:0000209; GO:0060765; GO:0070201; GO:0060632; GO:0010469; GO:0070848; GO:0051788; GO:0009636; GO:0048156; GO:0006351; GO:0042903; GO:0043162; GO:0008270 P21146; Q9NQ11; Q9HCU9; Q62623; Q14247; Q60598; Q9NQC7; P00533; P17252; P03409 "Hsp90 deacetylation; Hsp90 protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); aggresome; aggresome assembly; alpha-tubulin binding; caveola; cell leading edge; cellular response to hydrogen peroxide; cellular response to misfolded protein; cellular response to topologically incorrect protein; cytoplasmic microtubule; cytosol; dynein complex binding; enzyme binding; histone H3 deacetylation; histone H4 deacetylation; histone deacetylase activity; histone deacetylase complex; lysosome localization; macroautophagy; microtubule; microtubule associated complex; microtubule binding; misfolded or incompletely synthesized protein catabolic process; negative regulation of hydrogen peroxide metabolic process; negative regulation of microtubule depolymerization; negative regulation of oxidoreductase activity; negative regulation of protein complex disassembly; negative regulation of proteolysis; negative regulation of transcription, DNA-dependent; peptidyl-lysine deacetylation; perinuclear region of cytoplasm; polyubiquitin binding; polyubiquitinated misfolded protein transport; positive regulation of chaperone-mediated protein complex assembly; positive regulation of epithelial cell migration; positive regulation of hydrogen peroxide-mediated programmed cell death; positive regulation of receptor biosynthetic process; positive regulation of signal transduction; protein complex disassembly; protein polyubiquitination; regulation of androgen receptor signaling pathway; regulation of establishment of protein localization; regulation of microtubule-based movement; regulation of receptor activity; response to growth factor stimulus; response to misfolded protein; response to toxic substance; tau protein binding; transcription, DNA-dependent; tubulin deacetylase activity; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; zinc ion binding" IPR000286; IPR023801; IPR013083; IPR001607; Histone deacetylase 6 (HD6) (EC 3.5.1.98) HDAC6 KIAA0901 JM21 Homo sapiens (Human) TR36936_c0_g2_i1 P40937 RFC5_HUMAN 2.00E-172 GO:0005524; GO:0003677; GO:0005663; GO:0006271; GO:0019899; GO:0000278; GO:0005654; GO:0017111; GO:0006297; GO:0000722; GO:0032201; GO:0006283 P35249 "ATP binding; DNA binding; DNA replication factor C complex; DNA strand elongation involved in DNA replication; enzyme binding; mitotic cell cycle; nucleoplasm; nucleoside-triphosphatase activity; nucleotide-excision repair, DNA gap filling; telomere maintenance via recombination; telomere maintenance via semi-conservative replication; transcription-coupled nucleotide-excision repair" IPR003593; IPR003959; IPR008921; IPR027417; IPR013748; Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) RFC5 Homo sapiens (Human) TR36936_c0_g2_i2 A1RWU7 RFCS_THEPD 3.00E-71 GO:0005524; GO:0003689; GO:0006260; GO:0005663 ATP binding; DNA clamp loader activity; DNA replication; DNA replication factor C complex IPR003593; IPR003959; IPR000641; IPR008921; IPR027417; IPR023748; IPR013748; Replication factor C small subunit (RFC small subunit) (Clamp loader small subunit) rfcS Tpen_0267 Thermofilum pendens (strain Hrk 5) TR36939_c1_g1_i1 Q9Z1G4 VPP1_MOUSE 9.00E-47 GO:0015991; GO:0005737; GO:0030659; GO:0015078; GO:0016021; GO:0042470; GO:0000220 P49769 "ATP hydrolysis coupled proton transport; cytoplasm; cytoplasmic vesicle membrane; hydrogen ion transmembrane transporter activity; integral to membrane; melanosome; vacuolar proton-transporting V-type ATPase, V0 domain" IPR002490; IPR026028; V-type proton ATPase 116 kDa subunit a isoform 1 (V-ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1) Atp6v0a1 Atp6n1 Mus musculus (Mouse) TR36940_c0_g1_i1 Q8TCS8 PNPT1_HUMAN 0 GO:0000175; GO:0035458; GO:0034599; GO:0035198; GO:0000965; GO:0000964; GO:0045025; GO:0005758; GO:0000958; GO:0097222; GO:0070584; GO:0071850; GO:0045926; GO:0071042; GO:0005886; GO:0034046; GO:0008266; GO:0004654; GO:0061014; GO:2000627; GO:0000962; GO:0070207; GO:0035928; GO:0043457; GO:2000772 3'-5'-exoribonuclease activity; cellular response to interferon-beta; cellular response to oxidative stress; miRNA binding; mitochondrial RNA 3'-end processing; mitochondrial RNA 5'-end processing; mitochondrial degradosome; mitochondrial intermembrane space; mitochondrial mRNA catabolic process; mitochondrial mRNA polyadenylation; mitochondrion morphogenesis; mitotic cell cycle arrest; negative regulation of growth; nuclear polyadenylation-dependent mRNA catabolic process; plasma membrane; poly(G) RNA binding; poly(U) RNA binding; polyribonucleotide nucleotidyltransferase activity; positive regulation of mRNA catabolic process; positive regulation of miRNA catabolic process; positive regulation of mitochondrial RNA catabolic process; protein homotrimerization; rRNA import into mitochondrion; regulation of cellular respiration; regulation of cellular senescence IPR001247; IPR015847; IPR004087; IPR004088; IPR012340; IPR012162; IPR027408; IPR015848; IPR003029; IPR020568; IPR022967; "Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein)" PNPT1 PNPASE Homo sapiens (Human) TR36940_c0_g2_i1 P80870 GS13_BACSU 2.00E-06 GO:0003723; GO:0006950; GO:0005840; GO:0003735; GO:0006412 RNA binding; response to stress; ribosome; structural constituent of ribosome; translation IPR012340; IPR003029; IPR000110; IPR022967; General stress protein 13 (GSP13) yugI BSU31390 Bacillus subtilis (strain 168) TR36940_c0_g2_i2 P50889 RS1_LEULA 2.00E-06 GO:0003723; GO:0005840; GO:0003735; GO:0006412 RNA binding; ribosome; structural constituent of ribosome; translation IPR012340; IPR003029; IPR000110; IPR022967; 30S ribosomal protein S1 rps1 Leuconostoc lactis TR36941_c0_g1_i1 P18426 SCR11_OMMSL 5.00E-33 GO:0005212 structural constituent of eye lens IPR010987; IPR004045; IPR004046; IPR003083; IPR012336; S-crystallin SL11 (Major lens polypeptide) Ommastrephes sloanei (Arrow squid) (Sloane's squid) TR36941_c0_g1_i2 P46436 GST1_ASCSU 4.00E-37 GO:0004364 glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase 1 (EC 2.5.1.18) (GST class-sigma) GST1 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) TR36941_c0_g1_i3 P46425 GSTP2_MOUSE 1.00E-19 GO:0006749; GO:0004364 glutathione metabolic process; glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR003082; IPR012336; Glutathione S-transferase P 2 (Gst P2) (EC 2.5.1.18) (GST YF-YF) (GST class-pi) (GST-piA) Gstp2 Gstpia Mus musculus (Mouse) TR36941_c0_g1_i4 P15534 SCR3_NOTGO 7.00E-06 GO:0005212 structural constituent of eye lens IPR004045; IPR012336; S-crystallin 3 (Crystallin SIII) (Fragment) Nototodarus gouldi (Gould's flying squid) TR36943_c2_g1_i1 Q61330 CNTN2_MOUSE 3.00E-12 GO:0007628; GO:0031225; GO:0007411; GO:0007413; GO:0030246; GO:0007155; GO:0009986; GO:0022010; GO:0021853; GO:0045163; GO:0071206; GO:0001948; GO:0044224; GO:0007612; GO:0000226; GO:0043209; GO:0045665; GO:0001764; GO:0043025; GO:0033268; GO:0005886; GO:0060168; GO:0010954; GO:0031623; GO:0048710; GO:0031133; GO:0048168 adult walking behavior; anchored to membrane; axon guidance; axonal fasciculation; carbohydrate binding; cell adhesion; cell surface; central nervous system myelination; cerebral cortex GABAergic interneuron migration; clustering of voltage-gated potassium channels; establishment of protein localization to juxtaparanode region of axon; glycoprotein binding; juxtaparanode region of axon; learning; microtubule cytoskeleton organization; myelin sheath; negative regulation of neuron differentiation; neuron migration; neuronal cell body; node of Ranvier; plasma membrane; positive regulation of adenosine receptor signaling pathway; positive regulation of protein processing; receptor internalization; regulation of astrocyte differentiation; regulation of axon diameter; regulation of neuronal synaptic plasticity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Contactin-2 (Axonal glycoprotein TAG-1) (Axonin-1) (Transient axonal glycoprotein 1) (TAX-1) Cntn2 Tax Mus musculus (Mouse) TR36943_c2_g1_i2 Q92859 NEO1_HUMAN 4.00E-07 GO:0007411; GO:0007155; GO:0005887; GO:0055072; GO:0042692; GO:0007520; GO:0051149; GO:0004872; GO:0006355 "axon guidance; cell adhesion; integral to plasma membrane; iron ion homeostasis; muscle cell differentiation; myoblast fusion; positive regulation of muscle cell differentiation; receptor activity; regulation of transcription, DNA-dependent" IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR010560; Neogenin (Immunoglobulin superfamily DCC subclass member 2) NEO1 IGDCC2 NGN Homo sapiens (Human) TR36943_c2_g1_i3 O02827 MYLK_SHEEP 9.00E-06 GO:0005524; GO:0032154; GO:0005737; GO:0005856; GO:0030027; GO:0046872; GO:0004687 ATP binding; cleavage furrow; cytoplasm; cytoskeleton; lamellipodium; metal ion binding; myosin light chain kinase activity IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR020675; IPR000719; IPR002290; IPR008271; "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] (Fragment)" MYLK Ovis aries (Sheep) TR36943_c2_g3_i1 P34138 PTP2_DICDI 1.00E-13 GO:0031152; GO:0004725 aggregation involved in sorocarp development; protein tyrosine phosphatase activity IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase 2 (EC 3.1.3.48) (Protein-tyrosine-phosphate phosphohydrolase 2) (PTPA) ptpB ptp2 DDB_G0277865 Dictyostelium discoideum (Slime mold) TR36943_c2_g3_i2 P28203 PTP11_STYPL 2.00E-10 GO:0035335; GO:0004725 peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR000242; Tyrosine-protein phosphatase 11 (EC 3.1.3.48) (Fragment) STY-11 Styela plicata (Sea squirt) (Ascidia plicata) TR36943_c2_g3_i4 P23470 PTPRG_HUMAN 4.00E-29 GO:0005887; GO:0007169; GO:0005001 P35222 integral to plasma membrane; transmembrane receptor protein tyrosine kinase signaling pathway; transmembrane receptor protein tyrosine phosphatase activity IPR001148; IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48) PTPRG PTPG Homo sapiens (Human) TR36943_c2_g3_i5 O14522 PTPRT_HUMAN 2.00E-33 GO:0045294; GO:0009986; GO:0045295; GO:0007156; GO:0016021; GO:0005886; GO:0004725; GO:0016790; GO:0007169 P62993; Q99K10; Q69ZK9; Q9CS84; Q6P9K9; Q16849 alpha-catenin binding; cell surface; gamma-catenin binding; homophilic cell adhesion; integral to membrane; plasma membrane; protein tyrosine phosphatase activity; thiolester hydrolase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) TR36943_c2_g3_i6 P18433 PTPRA_HUMAN 2.00E-28 GO:0007411; GO:0008286; GO:0005887; GO:0006468; GO:0005001 P14781; P39688; P62993; P00523; P12931 axon guidance; insulin receptor signaling pathway; integral to plasma membrane; protein phosphorylation; transmembrane receptor protein tyrosine phosphatase activity IPR000387; IPR016130; IPR000242; IPR016336; IPR027262; Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) TR36945_c0_g2_i1 P03956 MMP1_HUMAN 4.00E-53 GO:0007596; GO:0005509; GO:0044267; GO:0030574; GO:0022617; GO:0005576; GO:0050900; GO:0004222; GO:0019048; GO:0005578; GO:0006508; GO:0008270 blood coagulation; calcium ion binding; cellular protein metabolic process; collagen catabolic process; extracellular matrix disassembly; extracellular region; leukocyte migration; metalloendopeptidase activity; modulation by virus of host morphology or physiology; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000585; IPR018487; IPR018486; IPR024079; IPR001818; IPR021190; IPR016293; IPR021158; IPR006026; IPR002477; Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase] MMP1 CLG Homo sapiens (Human) TR36945_c0_g2_i2 Q9XSZ5 MMP1_HORSE 3.00E-48 GO:0005509; GO:0030574; GO:0004222; GO:0005578; GO:0006508; GO:0008270 calcium ion binding; collagen catabolic process; metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000585; IPR018487; IPR018486; IPR024079; IPR001818; IPR021190; IPR016293; IPR021158; IPR006026; IPR002477; Interstitial collagenase (EC 3.4.24.7) (Matrix metalloproteinase-1) (MMP-1) MMP1 Equus caballus (Horse) TR36945_c0_g2_i3 Q9NPA2 MMP25_HUMAN 5.00E-55 GO:0031225; GO:0005509; GO:0009986; GO:0060022; GO:0006954; GO:0016020; GO:0004222; GO:0005886; GO:0005578; GO:0006508; GO:0008270 anchored to membrane; calcium ion binding; cell surface; hard palate development; inflammatory response; membrane; metalloendopeptidase activity; plasma membrane; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000585; IPR018487; IPR024079; IPR001818; IPR021190; IPR016293; IPR006026; IPR002477; Matrix metalloproteinase-25 (MMP-25) (EC 3.4.24.-) (Leukolysin) (Membrane-type matrix metalloproteinase 6) (MT-MMP 6) (MTMMP6) (Membrane-type-6 matrix metalloproteinase) (MT6-MMP) (MT6MMP) MMP25 MMP20 MMPL1 MT6MMP Homo sapiens (Human) TR36945_c0_g2_i5 Q9JHI0 MMP19_MOUSE 5.00E-74 GO:0031225; GO:0001525; GO:0005509; GO:0030154; GO:0030574; GO:0004222; GO:0005886; GO:0005578; GO:0006508; GO:0008270 anchored to membrane; angiogenesis; calcium ion binding; cell differentiation; collagen catabolic process; metalloendopeptidase activity; plasma membrane; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000585; IPR018487; IPR018486; IPR024079; IPR001818; IPR021190; IPR016293; IPR006026; IPR002477; Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI) Mmp19 Rasi Mus musculus (Mouse) TR36947_c1_g3_i1 Q9W4V8 TI50C_DROME 3.00E-40 GO:0016021; GO:0005744; GO:0007006; GO:0004722; GO:0015031; GO:0004725 integral to membrane; mitochondrial inner membrane presequence translocase complex; mitochondrial membrane organization; protein serine/threonine phosphatase activity; protein transport; protein tyrosine phosphatase activity IPR023214; IPR004274; IPR027111; Mitochondrial import inner membrane translocase subunit TIM50-C (Tiny tim 50) ttm50 CG2713 Drosophila melanogaster (Fruit fly) TR36947_c1_g3_i2 Q6BVY9 TIM50_DEBHA 3.00E-21 GO:0016021; GO:0005743; GO:0015031 integral to membrane; mitochondrial inner membrane; protein transport IPR023214; IPR004274; Mitochondrial import inner membrane translocase subunit TIM50 TIM50 DEHA2B15642g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR36947_c1_g3_i3 Q6NWD4 TIM50_DANRE 3.00E-42 GO:0006915; GO:0016021; GO:0005744; GO:0007006; GO:0004722; GO:0015031; GO:0004725 apoptotic process; integral to membrane; mitochondrial inner membrane presequence translocase complex; mitochondrial membrane organization; protein serine/threonine phosphatase activity; protein transport; protein tyrosine phosphatase activity IPR023214; IPR004274; IPR027111; Mitochondrial import inner membrane translocase subunit TIM50 timm50 tim50 zgc:66357 Danio rerio (Zebrafish) (Brachydanio rerio) TR36948_c1_g1_i4 Q5SPB6 CHAC1_DANRE 2.00E-51 GO:0005794; GO:0005112; GO:0007219; GO:0006915; GO:0005829; GO:0045746; GO:0010955; GO:0022008; GO:0006986; GO:0005802 Golgi apparatus; Notch binding; Notch signaling pathway; apoptotic process; cytosol; negative regulation of Notch signaling pathway; negative regulation of protein processing; neurogenesis; response to unfolded protein; trans-Golgi network IPR013024; IPR006840; Cation transport regulator-like protein 1 chac1 Danio rerio (Zebrafish) (Brachydanio rerio) TR36949_c1_g1_i1 Q14790 CASP8_HUMAN 3.00E-56 GO:0031265; GO:0030690; GO:0035666; GO:0006919; GO:0001525; GO:0044297; GO:0006921; GO:0071260; GO:0005813; GO:0097153; GO:0005829; GO:0031264; GO:0097191; GO:0007507; GO:0045087; GO:0097193; GO:0030225; GO:0045121; GO:0005741; GO:0019048; GO:0043124; GO:0001841; GO:0043005; GO:0070423; GO:0005634; GO:0043123; GO:0045651; GO:1900740; GO:0045862; GO:0051291; GO:0051603; GO:2001239; GO:0046677; GO:0032025; GO:0009409; GO:0032355; GO:0045471; GO:0032496; GO:0034612; GO:0097342; GO:0034138; GO:0034142 P51572; Q92851; Q9UKL3; O15519-1; Q13618; Q13158; P25445; P48023; Q13418; Q9UDY8; O60936; P29350; Q13546; O00220 CD95 death-inducing signaling complex; Noc1p-Noc2p complex; TRIF-dependent toll-like receptor signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cell body; cellular component disassembly involved in execution phase of apoptosis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; cytosol; death-inducing signaling complex; extrinsic apoptotic signaling pathway; heart development; innate immune response; intrinsic apoptotic signaling pathway; macrophage differentiation; membrane raft; mitochondrial outer membrane; modulation by virus of host morphology or physiology; negative regulation of I-kappaB kinase/NF-kappaB cascade; neural tube formation; neuron projection; nucleotide-binding oligomerization domain containing signaling pathway; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macrophage differentiation; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of proteolysis; protein heterooligomerization; proteolysis involved in cellular protein catabolic process; regulation of extrinsic apoptotic signaling pathway in absence of ligand; response to antibiotic; response to cobalt ion; response to cold; response to estradiol stimulus; response to ethanol; response to lipopolysaccharide; response to tumor necrosis factor; ripoptosome; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] CASP8 MCH5 Homo sapiens (Human) TR36949_c1_g1_i2 Q60431 CASP3_MESAU 1.00E-23 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 CPP32 Mesocricetus auratus (Golden hamster) TR36950_c3_g1_i1 Q9C5D2 FBL4_ARATH 3.00E-08 IPR001810; IPR006553; F-box/LRR-repeat protein 4 (AtFBL4) FBL4 At4g15475 dl3775w FCAALL.58 Arabidopsis thaliana (Mouse-ear cress) TR36950_c3_g2_i1 Q8BH70 FBXL4_MOUSE 2.00E-06 GO:0005737; GO:0005634 cytoplasm; nucleus IPR001810; IPR006553; F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) Fbxl4 Mus musculus (Mouse) TR36950_c3_g2_i2 Q9UJT9 FBXL7_HUMAN 5.00E-08 GO:0000086; GO:0019005; GO:0031146; GO:0051301; GO:0008283; GO:0005813; GO:0005737; GO:0007067; GO:0004842 G2/M transition of mitotic cell cycle; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; cell proliferation; centrosome; cytoplasm; mitosis; ubiquitin-protein ligase activity IPR001810; IPR006553; Protein modification; protein ubiquitination. F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7) FBXL7 FBL6 FBL7 KIAA0840 Homo sapiens (Human) TR36952_c0_g2_i4 P62744 AP2S1_RAT 5.00E-97 GO:0030121; GO:0030122; GO:0006886; GO:0008565; GO:0016192 AP-1 adaptor complex; AP-2 adaptor complex; intracellular protein transport; protein transporter activity; vesicle-mediated transport IPR016635; IPR022775; IPR000804; IPR011012; AP-2 complex subunit sigma (Adapter-related protein complex 2 subunit sigma) (Adaptor protein complex AP-2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma-adaptin 3b) (Sigma2-adaptin) Ap2s1 Ap17 Claps2 Rattus norvegicus (Rat) TR36953_c0_g1_i1 P42519 STAR_DROME 5.00E-16 GO:0005794; GO:0000139; GO:0048149; GO:0046845; GO:0046667; GO:0035225; GO:0005789; GO:0038004; GO:0007173; GO:0061331; GO:0007476; GO:0016021; GO:0007498; GO:0016318; GO:0048477; GO:0097038; GO:0007422; GO:0042461; GO:0005886; GO:0000042; GO:0048865; GO:0007421; GO:0007601 "Golgi apparatus; Golgi membrane; behavioral response to ethanol; branched duct epithelial cell fate determination, open tracheal system; compound eye retinal cell programmed cell death; determination of genital disc primordium; endoplasmic reticulum membrane; epidermal growth factor receptor ligand maturation; epidermal growth factor receptor signaling pathway; epithelial cell proliferation involved in Malpighian tubule morphogenesis; imaginal disc-derived wing morphogenesis; integral to membrane; mesoderm development; ommatidial rotation; oogenesis; perinuclear endoplasmic reticulum; peripheral nervous system development; photoreceptor cell development; plasma membrane; protein targeting to Golgi; stem cell fate commitment; stomatogastric nervous system development; visual perception" IPR006342; Protein Star S CG4385 Drosophila melanogaster (Fruit fly) TR36954_c0_g1_i1 Q6Q4H1 JMJD6_HYDVU 2.00E-10 GO:0016568; GO:0046872; GO:0005634; GO:0070815; GO:0018395; GO:0006355; GO:0006351 "chromatin modification; metal ion binding; nucleus; peptidyl-lysine 5-dioxygenase activity; peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003347; Bifunctional arginine demethylase and lysyl-hydroxylase PSR (EC 1.14.11.-) (Phosphatidylserine receptor) PSR Hydra vulgaris (Hydra) (Hydra attenuata) TR36954_c0_g1_i2 Q6AY40 JMJD8_RAT 9.00E-93 IPR003347; JmjC domain-containing protein 8 (Jumonji domain-containing protein 8) Jmjd8 Rattus norvegicus (Rat) TR36956_c1_g1_i5 Q3UU96 MRCKA_MOUSE 4.00E-11 GO:0005524; GO:0031532; GO:0005737; GO:0035556; GO:0046872; GO:0000226; GO:0007097; GO:0005543; GO:0004674; GO:0005083 ATP binding; actin cytoskeleton reorganization; cytoplasm; intracellular signal transduction; metal ion binding; microtubule cytoskeleton organization; nuclear migration; phospholipid binding; protein serine/threonine kinase activity; small GTPase regulator activity IPR000961; IPR001180; IPR000095; IPR011009; IPR014930; IPR011993; IPR017892; IPR001849; IPR002219; IPR000719; IPR017441; IPR002290; IPR008271; IPR026611; Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) Cdc42bpa Kiaa0451 Mus musculus (Mouse) TR36956_c1_g1_i8 Q3UU96 MRCKA_MOUSE 7.00E-11 GO:0005524; GO:0031532; GO:0005737; GO:0035556; GO:0046872; GO:0000226; GO:0007097; GO:0005543; GO:0004674; GO:0005083 ATP binding; actin cytoskeleton reorganization; cytoplasm; intracellular signal transduction; metal ion binding; microtubule cytoskeleton organization; nuclear migration; phospholipid binding; protein serine/threonine kinase activity; small GTPase regulator activity IPR000961; IPR001180; IPR000095; IPR011009; IPR014930; IPR011993; IPR017892; IPR001849; IPR002219; IPR000719; IPR017441; IPR002290; IPR008271; IPR026611; Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) Cdc42bpa Kiaa0451 Mus musculus (Mouse) TR36957_c0_g1_i4 O89107 DNSL3_RAT 4.00E-69 GO:0003677; GO:0006309; GO:0004520; GO:0016888; GO:0005634 "DNA binding; apoptotic DNA fragmentation; endodeoxyribonuclease activity; endodeoxyribonuclease activity, producing 5'-phosphomonoesters; nucleus" IPR018057; IPR016202; IPR005135; Deoxyribonuclease gamma (DNase gamma) (EC 3.1.21.-) (DNaseY) (Deoxyribonuclease I-like 3) (DNase I-like 3) Dnase1l3 Rattus norvegicus (Rat) TR36958_c0_g1_i1 Q96DY2 IQCD_HUMAN 2.00E-43 IPR000048; IQ domain-containing protein D IQCD Homo sapiens (Human) TR36959_c0_g1_i1 Q9ZCL3 Y714_RICPR 2.00E-09 IPR002110; IPR020683; Putative ankyrin repeat protein RP714 RP714 Rickettsia prowazekii (strain Madrid E) TR36959_c0_g5_i1 Q8Q0U0 Y045_METMA 8.00E-19 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR36959_c0_g8_i1 A2A690 TANC2_MOUSE 0 GO:0001701 in utero embryonic development IPR002110; IPR020683; IPR027417; IPR013026; IPR011990; IPR019734; "Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2)" Tanc2 Kiaa1148 Mus musculus (Mouse) TR36960_c0_g1_i1 P02460 CO2A1_CHICK 3.00E-26 GO:0005604; GO:0001502; GO:0060351; GO:0071773; GO:0007417; GO:0002062; GO:0030199; GO:0005585; GO:0005737; GO:0060272; GO:0001958; GO:0005201; GO:0005615; GO:0003007; GO:0042472; GO:0060174; GO:0046872; GO:0043066; GO:0030903; GO:0071599; GO:0060021; GO:0006029; GO:0010468; GO:0007605; GO:0001894; GO:0007601 basement membrane; cartilage condensation; cartilage development involved in endochondral bone morphogenesis; cellular response to BMP stimulus; central nervous system development; chondrocyte differentiation; collagen fibril organization; collagen type II; cytoplasm; embryonic skeletal joint morphogenesis; endochondral ossification; extracellular matrix structural constituent; extracellular space; heart morphogenesis; inner ear morphogenesis; limb bud formation; metal ion binding; negative regulation of apoptotic process; notochord development; otic vesicle development; palate development; proteoglycan metabolic process; regulation of gene expression; sensory perception of sound; tissue homeostasis; visual perception IPR008160; IPR000885; Collagen alpha-1(II) chain (Alpha-1 type II collagen) (Fragment) COL2A1 Gallus gallus (Chicken) TR36960_c0_g1_i2 P08121 CO3A1_MOUSE 8.00E-23 GO:0001568; GO:0007160; GO:0071230; GO:0021987; GO:0032964; GO:0030199; GO:0005586; GO:0048565; GO:0043206; GO:0005201; GO:0005615; GO:0007507; GO:0007229; GO:0046872; GO:0050777; GO:2001223; GO:0018149; GO:0035025; GO:0034097; GO:0009314; GO:0001501; GO:0043588; GO:0007179; GO:0042060 blood vessel development; cell-matrix adhesion; cellular response to amino acid stimulus; cerebral cortex development; collagen biosynthetic process; collagen fibril organization; collagen type III; digestive tract development; extracellular fibril organization; extracellular matrix structural constituent; extracellular space; heart development; integrin-mediated signaling pathway; metal ion binding; negative regulation of immune response; negative regulation of neuron migration; peptide cross-linking; positive regulation of Rho protein signal transduction; response to cytokine stimulus; response to radiation; skeletal system development; skin development; transforming growth factor beta receptor signaling pathway; wound healing IPR008160; IPR000885; IPR001007; Collagen alpha-1(III) chain Col3a1 Mus musculus (Mouse) TR36961_c0_g1_i1 Q6P0I8 EXOS6_DANRE 6.00E-90 GO:0003723; GO:0005737; GO:0000178; GO:0005730; GO:0006364 RNA binding; cytoplasm; exosome (RNase complex); nucleolus; rRNA processing IPR001247; IPR015847; IPR027408; IPR020568; Exosome complex component MTR3 (Exosome component 6) (mRNA transport regulator 3 homolog) exosc6 mtr3 Danio rerio (Zebrafish) (Brachydanio rerio) TR36961_c0_g1_i3 Q6P0I8 EXOS6_DANRE 2.00E-64 GO:0003723; GO:0005737; GO:0000178; GO:0005730; GO:0006364 RNA binding; cytoplasm; exosome (RNase complex); nucleolus; rRNA processing IPR001247; IPR015847; IPR027408; IPR020568; Exosome complex component MTR3 (Exosome component 6) (mRNA transport regulator 3 homolog) exosc6 mtr3 Danio rerio (Zebrafish) (Brachydanio rerio) TR36963_c0_g1_i2 P62909 RS3_RAT 3.00E-151 GO:0003723; GO:0022627; GO:0030425; GO:0012505; GO:0003735; GO:0006412 RNA binding; cytosolic small ribosomal subunit; dendrite; endomembrane system; structural constituent of ribosome; translation IPR004087; IPR015946; IPR004044; IPR009019; IPR001351; IPR018280; IPR005703; 40S ribosomal protein S3 Rps3 Rattus norvegicus (Rat) TR36964_c1_g1_i1 P00522 ABL_DROME 1.00E-11 GO:0005524; GO:0045179; GO:0030424; GO:0016199; GO:0005911; GO:0007417; GO:0007303; GO:0005829; GO:0007391; GO:0003382; GO:0019897; GO:0008045; GO:0005927; GO:0045886; GO:0001764; GO:0004715; GO:0003402; GO:0008064; GO:0008360; GO:0032880; GO:0031647; GO:0007370 Q8T4F7; P16621 "ATP binding; apical cortex; axon; axon midline choice point recognition; cell-cell junction; central nervous system development; cytoplasmic transport, nurse cell to oocyte; cytosol; dorsal closure; epithelial cell morphogenesis; extrinsic to plasma membrane; motor neuron axon guidance; muscle tendon junction; negative regulation of synaptic growth at neuromuscular junction; neuron migration; non-membrane spanning protein tyrosine kinase activity; planar cell polarity pathway involved in axis elongation; regulation of actin polymerization or depolymerization; regulation of cell shape; regulation of protein localization; regulation of protein stability; ventral furrow formation" IPR015015; IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase Abl (EC 2.7.10.2) (D-ash) (Protein abelson) Abl ABL-1 Dash CG4032 Drosophila melanogaster (Fruit fly) TR36964_c1_g1_i2 P00521 ABL_MLVAB 8.00E-70 GO:0005524; GO:0004715; GO:0018108 ATP binding; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR015015; IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR008266; IPR020635; Tyrosine-protein kinase transforming protein Abl (EC 2.7.10.2) (V-abl) ABL Abelson murine leukemia virus TR36964_c1_g1_i5 P42159 RTK2_GEOCY 6.00E-15 GO:0005524; GO:0016021; GO:0018108; GO:0005886; GO:0004714; GO:0007169 ATP binding; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR007110; IPR013783; IPR011009; IPR000719; IPR001245; IPR008266; IPR020635; IPR002011; Class II receptor tyrosine kinase (EC 2.7.10.1) (GCTK) TK Geodia cydonium (Sponge) TR36964_c2_g1_i1 Q6XHB2 ROCO4_DICDI 7.00E-12 GO:0005524; GO:0005525; GO:0005829; GO:0004672; GO:0004674; GO:0031153; GO:0007264; GO:0031150 ATP binding; GTP binding; cytosol; protein kinase activity; protein serine/threonine kinase activity; slug development involved in sorocarp development; small GTPase mediated signal transduction; sorocarp stalk development IPR011009; IPR001611; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR001245; IPR015943; IPR001680; IPR017986; Probable serine/threonine-protein kinase roco4 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 4) roco4 DDB_G0288251 Dictyostelium discoideum (Slime mold) TR36966_c0_g2_i1 P35859 ALS_RAT 2.00E-39 GO:0007155; GO:0005520; GO:0042567; GO:0043231; GO:0007165 cell adhesion; insulin-like growth factor binding; insulin-like growth factor ternary complex; intracellular membrane-bounded organelle; signal transduction IPR000483; IPR001611; IPR003591; IPR000372; Insulin-like growth factor-binding protein complex acid labile subunit (ALS) Igfals Als Rattus norvegicus (Rat) TR36966_c0_g2_i2 P70389 ALS_MOUSE 9.00E-36 GO:0007155; GO:0005615 cell adhesion; extracellular space IPR000483; IPR001611; IPR003591; IPR000372; Insulin-like growth factor-binding protein complex acid labile subunit (ALS) Igfals Albs Als Mus musculus (Mouse) TR36966_c0_g2_i3 P35858 ALS_HUMAN 1.00E-40 GO:0007155; GO:0044267; GO:0005615; GO:0005520; GO:0005634; GO:0007165 cell adhesion; cellular protein metabolic process; extracellular space; insulin-like growth factor binding; nucleus; signal transduction IPR000483; IPR001611; IPR003591; IPR000372; Insulin-like growth factor-binding protein complex acid labile subunit (ALS) IGFALS ALS Homo sapiens (Human) TR36967_c0_g1_i1 P23141 EST1_HUMAN 6.00E-72 GO:0004091; GO:0005788; GO:0047374; GO:0009636 carboxylesterase activity; endoplasmic reticulum lumen; methylumbelliferyl-acetate deacetylase activity; response to toxic substance IPR002018; IPR019826; IPR019819; Liver carboxylesterase 1 (Acyl-coenzyme A:cholesterol acyltransferase) (ACAT) (Brain carboxylesterase hBr1) (Carboxylesterase 1) (CE-1) (hCE-1) (EC 3.1.1.1) (Cocaine carboxylesterase) (Egasyn) (HMSE) (Methylumbelliferyl-acetate deacetylase 1) (EC 3.1.1.56) (Monocyte/macrophage serine esterase) (Retinyl ester hydrolase) (REH) (Serine esterase 1) (Triacylglycerol hydrolase) (TGH) CES1 CES2 SES1 Homo sapiens (Human) TR36967_c0_g1_i2 P30122 CEL_BOVIN 1.00E-77 GO:0047372; GO:0004091; GO:0005829; GO:0005615; GO:0016042; GO:0004771; GO:0004806 acylglycerol lipase activity; carboxylesterase activity; cytosol; extracellular space; lipid catabolic process; sterol esterase activity; triglyceride lipase activity IPR002018; IPR019826; IPR019819; Bile salt-activated lipase (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Cholesterol esterase) (Pancreatic lysophospholipase) (Sterol esterase) (Fragment) CEL Bos taurus (Bovine) TR36967_c0_g1_i4 P04058 ACES_TORCA 2.00E-73 GO:0001507; GO:0003990; GO:0031225; GO:0004091; GO:0030054; GO:0005886; GO:0045202 acetylcholine catabolic process in synaptic cleft; acetylcholinesterase activity; anchored to membrane; carboxylesterase activity; cell junction; plasma membrane; synapse IPR000908; IPR002018; IPR019826; IPR019819; IPR000997; Acetylcholinesterase (AChE) (EC 3.1.1.7) ache Torpedo californica (Pacific electric ray) TR36969_c3_g1_i1 Q9BY76 ANGL4_HUMAN 2.00E-31 GO:0001525; GO:0030154; GO:0044255; GO:0004857; GO:0005615; GO:0043066; GO:0051005; GO:0045766; GO:0051260; GO:0005578; GO:0001666; GO:0044281; GO:0070328 P05556; P18084 angiogenesis; cell differentiation; cellular lipid metabolic process; enzyme inhibitor activity; extracellular space; negative regulation of apoptotic process; negative regulation of lipoprotein lipase activity; positive regulation of angiogenesis; protein homooligomerization; proteinaceous extracellular matrix; response to hypoxia; small molecule metabolic process; triglyceride homeostasis IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-related protein 4 (Angiopoietin-like protein 4) (Hepatic fibrinogen/angiopoietin-related protein) (HFARP) ANGPTL4 ARP4 HFARP PGAR PP1158 PSEC0166 UNQ171/PRO197 Homo sapiens (Human) TR36969_c3_g2_i2 Q95LU3 FBCD1_MACFA 1.00E-62 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR36969_c3_g2_i4 Q86XS5 ANGL5_HUMAN 1.00E-37 GO:0005576 extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-related protein 5 (Angiopoietin-like protein 5) ANGPTL5 UNQ5795/PRO19600 Homo sapiens (Human) TR36969_c3_g3_i4 P33573 FIBA2_PETMA 1.00E-33 GO:0005577; GO:0030168; GO:0051258; GO:0007165 fibrinogen complex; platelet activation; protein polymerization; signal transduction IPR014716; IPR014715; IPR002181; IPR012290; IPR020837; Fibrinogen alpha-2 chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha-2 chain] Petromyzon marinus (Sea lamprey) TR36969_c3_g3_i5 Q95LU3 FBCD1_MACFA 1.00E-65 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR36969_c3_g3_i6 E2IYB3 FCNV1_VARKO 4.00E-31 GO:0005576 extracellular region IPR008160; IPR014716; IPR002181; Veficolin-1 (Fragment) Varanus komodoensis (Komodo dragon) TR36971_c1_g1_i19 Q5S006 LRRK2_MOUSE 6.00E-08 GO:0005524; GO:0005525; GO:0034211; GO:0005096; GO:0003924; GO:0004708; GO:0000186; GO:0006914; GO:0032839; GO:0008340; GO:0035640; GO:0032473; GO:0048312; GO:0045121; GO:0034260; GO:2000173; GO:0061002; GO:0007406; GO:0014043; GO:0007528; GO:0070997; GO:0043025; GO:0018105; GO:0018107; GO:0005886; GO:0010508; GO:0060161; GO:0043068; GO:0032436; GO:0031398; GO:0046777; GO:0035564; GO:0040012; GO:0042391; GO:0006979; GO:0007264; GO:0008021; GO:0022028; GO:0005802 Itself; Q9EPJ9; Q8K1M6; P46460; Q9CQV8; P62259; P61982; P68510; P68254; P63101 ATP binding; GTP binding; GTP-dependent protein kinase activity; GTPase activator activity; GTPase activity; MAP kinase kinase activity; activation of MAPKK activity; autophagy; dendrite cytoplasm; determination of adult lifespan; exploration behavior; external side of mitochondrial outer membrane; intracellular distribution of mitochondria; membrane raft; negative regulation of GTPase activity; negative regulation of branching morphogenesis of a nerve; negative regulation of dendritic spine morphogenesis; negative regulation of neuroblast proliferation; negative regulation of neuron maturation; neuromuscular junction development; neuron death; neuronal cell body; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; plasma membrane; positive regulation of autophagy; positive regulation of dopamine receptor signaling pathway; positive regulation of programmed cell death; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; protein autophosphorylation; regulation of kidney size; regulation of locomotion; regulation of membrane potential; response to oxidative stress; small GTPase mediated signal transduction; synaptic vesicle; tangential migration from the subventricular zone to the olfactory bulb; trans-Golgi network IPR002110; IPR020683; IPR011989; IPR016024; IPR011009; IPR001611; IPR025875; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR008271; IPR005225; IPR001806; IPR015943; IPR001680; IPR017986; Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) Lrrk2 Mus musculus (Mouse) TR36971_c1_g1_i5 Q1ZXD6 ROCO5_DICDI 2.00E-08 GO:0005524; GO:0005525; GO:0005089; GO:0005622; GO:0005543; GO:0004674; GO:0035023; GO:0007264; GO:0030587 ATP binding; GTP binding; Rho guanyl-nucleotide exchange factor activity; intracellular; phospholipid binding; protein serine/threonine kinase activity; regulation of Rho protein signal transduction; small GTPase mediated signal transduction; sorocarp development IPR000219; IPR011009; IPR001611; IPR025875; IPR003591; IPR013684; IPR027417; IPR011993; IPR001849; IPR000719; IPR017441; IPR020859; IPR001245; IPR008271; IPR001806; Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) TR36973_c0_g1_i1 B0JZG0 S23A2_XENTR 1.00E-102 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR006042; IPR006043; Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36973_c0_g1_i2 Q6SZ87 NAT11_ARATH 1.00E-43 GO:0016021; GO:0005886; GO:0055085; GO:0005215 integral to membrane; plasma membrane; transmembrane transport; transporter activity IPR006043; Nucleobase-ascorbate transporter 11 (AtNAT11) NAT11 At4g38050 F20D10.170 Arabidopsis thaliana (Mouse-ear cress) TR36973_c0_g1_i4 B0JZG0 S23A2_XENTR 7.00E-103 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR006042; IPR006043; Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36973_c0_g1_i6 Q9EPR4 S23A2_MOUSE 1.00E-98 GO:0008520; GO:0019852; GO:0015882; GO:0016324; GO:0009925; GO:0005737; GO:0005887; GO:0006979; GO:0070890; GO:0070904 L-ascorbate:sodium symporter activity; L-ascorbic acid metabolic process; L-ascorbic acid transport; apical plasma membrane; basal plasma membrane; cytoplasm; integral to plasma membrane; response to oxidative stress; sodium-dependent L-ascorbate transmembrane transporter activity; transepithelial L-ascorbic acid transport IPR006042; IPR006043; Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) (SVCT-2) (mSVCT2) (Yolk sac permease-like molecule 2) Slc23a2 Kiaa0238 Svct2 Yspl2 Mus musculus (Mouse) TR36974_c0_g1_i1 P48067 SC6A9_HUMAN 6.00E-136 GO:0015375; GO:0005887; GO:0005328 glycine:sodium symporter activity; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) SLC6A9 Homo sapiens (Human) TR36974_c0_g1_i4 Q62687 S6A18_RAT 2.00E-82 GO:0006865; GO:0006972; GO:0005887; GO:0005328 amino acid transport; hyperosmotic response; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR002438; Sodium-dependent neutral amino acid transporter B(0)AT3 (Renal osmotic stress-induced Na-Cl organic solute cotransporter) (ROSIT) (Sodium- and chloride-dependent transporter XTRP2) (Solute carrier family 6 member 18) (System B(0) neutral amino acid transporter AT3) Slc6a18 Xtrp2 Rattus norvegicus (Rat) TR36974_c0_g2_i1 P30531 SC6A1_HUMAN 4.00E-59 GO:0030424; GO:0009986; GO:0051939; GO:0005332; GO:0016021; GO:0005887; GO:0007612; GO:0032229; GO:0007269; GO:0005328; GO:0005886; GO:0014054; GO:0051260; GO:0051592; GO:0042220; GO:0032355; GO:0010288; GO:0014074; GO:0009744; GO:0009636; GO:0055085 "axon; cell surface; gamma-aminobutyric acid import; gamma-aminobutyric acid:sodium symporter activity; integral to membrane; integral to plasma membrane; learning; negative regulation of synaptic transmission, GABAergic; neurotransmitter secretion; neurotransmitter:sodium symporter activity; plasma membrane; positive regulation of gamma-aminobutyric acid secretion; protein homooligomerization; response to calcium ion; response to cocaine; response to estradiol stimulus; response to lead ion; response to purine-containing compound; response to sucrose stimulus; response to toxic substance; transmembrane transport" IPR000175; IPR002980; Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) SLC6A1 GABATR GABT1 GAT1 Homo sapiens (Human) TR36974_c0_g2_i5 P31647 S6A11_RAT 3.00E-44 GO:0007420; GO:0042995; GO:0005737; GO:0005332; GO:0005887; GO:0016020; GO:0042165; GO:0006836; GO:0005328; GO:0042493 brain development; cell projection; cytoplasm; gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; membrane; neurotransmitter binding; neurotransmitter transport; neurotransmitter:sodium symporter activity; response to drug IPR000175; IPR002982; Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11) Slc6a11 Gabt3 Gat-3 Gat-b Rattus norvegicus (Rat) TR36974_c0_g2_i6 P30531 SC6A1_HUMAN 5.00E-64 GO:0030424; GO:0009986; GO:0051939; GO:0005332; GO:0016021; GO:0005887; GO:0007612; GO:0032229; GO:0007269; GO:0005328; GO:0005886; GO:0014054; GO:0051260; GO:0051592; GO:0042220; GO:0032355; GO:0010288; GO:0014074; GO:0009744; GO:0009636; GO:0055085 "axon; cell surface; gamma-aminobutyric acid import; gamma-aminobutyric acid:sodium symporter activity; integral to membrane; integral to plasma membrane; learning; negative regulation of synaptic transmission, GABAergic; neurotransmitter secretion; neurotransmitter:sodium symporter activity; plasma membrane; positive regulation of gamma-aminobutyric acid secretion; protein homooligomerization; response to calcium ion; response to cocaine; response to estradiol stimulus; response to lead ion; response to purine-containing compound; response to sucrose stimulus; response to toxic substance; transmembrane transport" IPR000175; IPR002980; Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) SLC6A1 GABATR GABT1 GAT1 Homo sapiens (Human) TR36975_c0_g1_i1 Q9GUM2 BRE4_CAEEL 2.00E-78 GO:0033207; GO:0075015; GO:0016021; GO:0046872; GO:0045747; GO:0006486; GO:0009636 "beta-1,4-N-acetylgalactosaminyltransferase activity; formation of infection structure on or near host; integral to membrane; metal ion binding; positive regulation of Notch signaling pathway; protein glycosylation; response to toxic substance" IPR003859; IPR027791; IPR027995; Protein modification; protein glycosylation. "Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.-) (Bacillus thuringiensis toxin-resistant protein 4) (Bt toxin-resistant protein 4) (Beta-4-GalNAcT)" bre-4 Y73E7A.7 Caenorhabditis elegans TR36976_c2_g1_i1 Q8K2W3 TXD11_MOUSE 2.00E-46 GO:0045454; GO:0005789; GO:0016021 cell redox homeostasis; endoplasmic reticulum membrane; integral to membrane IPR012336; IPR013766; Thioredoxin domain-containing protein 11 Txndc11 Mus musculus (Mouse) TR36976_c3_g2_i1 Q6PKC3 TXD11_HUMAN 7.00E-41 GO:0045454; GO:0005789; GO:0016021 cell redox homeostasis; endoplasmic reticulum membrane; integral to membrane IPR012336; IPR013766; Thioredoxin domain-containing protein 11 (EF-hand-binding protein 1) TXNDC11 EFP1 Homo sapiens (Human) TR36977_c0_g1_i1 Q9BW85 CCD94_HUMAN 5.00E-72 IPR007590; Coiled-coil domain-containing protein 94 CCDC94 Homo sapiens (Human) TR36978_c0_g1_i1 Q5JI69 TDH_PYRKO 1.00E-70 GO:0008743; GO:0019518; GO:0005737; GO:0008270 L-threonine 3-dehydrogenase activity; L-threonine catabolic process to glycine; cytoplasm; zinc ion binding IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR004627; IPR016040; Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2. Probable L-threonine 3-dehydrogenase (EC 1.1.1.103) tdh TK0916 Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) TR36978_c0_g1_i2 P14941 ADH_THEBR 9.00E-06 GO:0050009; GO:0008270 isopropanol dehydrogenase (NADP+) activity; zinc ion binding IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; NADP-dependent isopropanol dehydrogenase (EC 1.1.1.80) adh Thermoanaerobacter brockii (Thermoanaerobium brockii) TR36979_c1_g1_i1 P95329 MASY_MYXXD 2.00E-113 GO:0005737; GO:0006097; GO:0004474; GO:0006099 cytoplasm; glyoxylate cycle; malate synthase activity; tricarboxylic acid cycle IPR011076; IPR006252; IPR001465; IPR019830; Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2. Malate synthase (EC 2.3.3.9) mls MXAN_6441 Myxococcus xanthus (strain DK 1622) TR36981_c0_g3_i1 P83425 HIP_MYTED 3.00E-11 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR36983_c2_g1_i1 Q0III3 DC1I2_BOVIN 0 GO:0005868; GO:0005874; GO:0007018; GO:0003774; GO:0006810; GO:0031982 cytoplasmic dynein complex; microtubule; microtubule-based movement; motor activity; transport; vesicle IPR025956; IPR015943; IPR001680; IPR017986; "Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)" DYNC1I2 Bos taurus (Bovine) TR36983_c2_g1_i2 O93377 RBP4A_XENLA 3.00E-07 GO:0033186; GO:0006260; GO:0035098; GO:0007049; GO:0031497; GO:0016568; GO:0006355; GO:0006351 "CAF-1 complex; DNA replication; ESC/E(Z) complex; cell cycle; chromatin assembly; chromatin modification; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR020472; IPR022052; IPR015943; IPR001680; IPR019775; IPR017986; Histone-binding protein RBBP4-A (Retinoblastoma-binding protein 4-A) (RBBP-4-A) (Retinoblastoma-binding protein p48-A) rbbp4-a rbap48-a Xenopus laevis (African clawed frog) TR36983_c2_g1_i3 Q9XF57 PEX7_ARATH 4.00E-07 GO:0080008; GO:0005778; GO:0006625 Cul4-RING ubiquitin ligase complex; peroxisomal membrane; protein targeting to peroxisome IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Peroxisome biogenesis protein 7 (Peroxin-7) (AtPEX7) (Peroxisomal targeting signal type 2 receptor) (Pex7p) PEX7 At1g29260 F28N24.6 Arabidopsis thaliana (Mouse-ear cress) TR36983_c2_g1_i4 Q0III3 DC1I2_BOVIN 0 GO:0005868; GO:0005874; GO:0007018; GO:0003774; GO:0006810; GO:0031982 cytoplasmic dynein complex; microtubule; microtubule-based movement; motor activity; transport; vesicle IPR025956; IPR015943; IPR001680; IPR017986; "Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)" DYNC1I2 Bos taurus (Bovine) TR36984_c2_g1_i1 Q91858 TAF12_XENLA 4.00E-53 GO:0006352; GO:0006355; GO:0005669 "DNA-dependent transcription, initiation; regulation of transcription, DNA-dependent; transcription factor TFIID complex" IPR009072; IPR003228; Transcription initiation factor TFIID subunit 12 (TFIID subunit p22) (Transcription initiation factor TFIID 20/15 kDa subunits) (TAFII-20/TAFII-15) (TAFII20/TAFII15) taf12 Xenopus laevis (African clawed frog) TR36984_c2_g1_i9 Q91858 TAF12_XENLA 5.00E-53 GO:0006352; GO:0006355; GO:0005669 "DNA-dependent transcription, initiation; regulation of transcription, DNA-dependent; transcription factor TFIID complex" IPR009072; IPR003228; Transcription initiation factor TFIID subunit 12 (TFIID subunit p22) (Transcription initiation factor TFIID 20/15 kDa subunits) (TAFII-20/TAFII-15) (TAFII20/TAFII15) taf12 Xenopus laevis (African clawed frog) TR36987_c0_g1_i1 O75179 ANR17_HUMAN 0 GO:0003723; GO:0001955; GO:0005737; GO:0019048; GO:0051151; GO:0005634 RNA binding; blood vessel maturation; cytoplasm; modulation by virus of host morphology or physiology; negative regulation of smooth muscle cell differentiation; nucleus IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) TR36987_c0_g2_i1 Q5UPG5 YL093_MIMIV 2.00E-34 IPR002110; IPR020683; Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) TR36987_c0_g2_i2 Q21920 ANKHM_CAEEL 1.00E-137 GO:0003723; GO:0005737 RNA binding; cytoplasm IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat and KH domain-containing protein R11A8.7 R11A8.7 Caenorhabditis elegans TR36989_c0_g1_i4 Q9UEW8 STK39_HUMAN 2.00E-31 GO:0005524; GO:0016324; GO:0016323; GO:0005737; GO:0005856; GO:0005634; GO:0043268; GO:0004702; GO:0050727; GO:0006950 Q9Y376 ATP binding; apical plasma membrane; basolateral plasma membrane; cytoplasm; cytoskeleton; nucleus; positive regulation of potassium ion transport; receptor signaling protein serine/threonine kinase activity; regulation of inflammatory response; response to stress IPR011009; IPR024678; IPR000719; IPR017441; IPR002290; STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) STK39 SPAK Homo sapiens (Human) TR36989_c0_g3_i1 Q6P9R2 OXSR1_MOUSE 3.00E-143 GO:0005524; GO:0005737; GO:0007243; GO:0000287; GO:0004674; GO:0006979 ATP binding; cytoplasm; intracellular protein kinase cascade; magnesium ion binding; protein serine/threonine kinase activity; response to oxidative stress IPR011009; IPR024678; IPR000719; IPR017441; IPR002290; Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) Oxsr1 Osr1 Mus musculus (Mouse) TR36992_c0_g1_i1 Q6UXM1 LRIG3_HUMAN 6.00E-165 GO:0030659; GO:0016021; GO:0007275; GO:0005886 cytoplasmic vesicle membrane; integral to membrane; multicellular organismal development; plasma membrane IPR000483; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR001611; IPR025875; IPR003591; IPR000372; Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) LRIG3 LIG3 UNQ287/PRO326/PRO335 Homo sapiens (Human) TR36994_c0_g1_i1 Q8K2J9 BTBD6_MOUSE 5.00E-76 GO:0000932 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6 Btbd6 Mus musculus (Mouse) TR36994_c0_g1_i2 Q96KE9 BTBD6_HUMAN 2.00E-74 GO:0000932 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6 (Lens BTB domain protein) BTBD6 BDPL Homo sapiens (Human) TR36995_c0_g2_i1 Q9QYM0 MRP5_RAT 2.00E-51 GO:0005524; GO:0006200; GO:0042626; GO:0016021; GO:0048471; GO:0032868; GO:0032496 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; perinuclear region of cytoplasm; response to insulin stimulus; response to lipopolysaccharide" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) Abcc5 Abcc5a Mrp5 Rattus norvegicus (Rat) TR36995_c2_g1_i1 Q8CG09 MRP1_RAT 8.00E-179 GO:0005524; GO:0016323; GO:0060326; GO:0005737; GO:0043215; GO:0046618; GO:0015562; GO:0015431; GO:0034775; GO:0034634; GO:0005887; GO:0034040; GO:0005324; GO:1901215; GO:0016491; GO:0033700; GO:0015911; GO:0030335; GO:0006979; GO:0046624; GO:0008559 ATP binding; basolateral plasma membrane; cell chemotaxis; cytoplasm; daunorubicin transport; drug export; efflux transmembrane transporter activity; glutathione S-conjugate-exporting ATPase activity; glutathione transmembrane transport; glutathione transmembrane transporter activity; integral to plasma membrane; lipid-transporting ATPase activity; long-chain fatty acid transporter activity; negative regulation of neuron death; oxidoreductase activity; phospholipid efflux; plasma membrane long-chain fatty acid transport; positive regulation of cell migration; response to oxidative stress; sphingolipid transporter activity; xenobiotic-transporting ATPase activity IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR018170; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) Abcc1 Mrp1 Rattus norvegicus (Rat) TR36995_c3_g1_i1 Q8HXQ5 MRP1_BOVIN 0 GO:0005524; GO:0006200; GO:0042626; GO:0016021; GO:0005886 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; plasma membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP1 Bos taurus (Bovine) TR36995_c3_g1_i3 Q92887 MRP2_HUMAN 3.00E-174 GO:0005524; GO:0042626; GO:0016324; GO:0030644; GO:0006855; GO:0005887; GO:0046581; GO:0008514; GO:0015732; GO:0046685; GO:0009408; GO:0031427; GO:0006979; GO:0070327 P19838 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; apical plasma membrane; cellular chloride ion homeostasis; drug transmembrane transport; integral to plasma membrane; intercellular canaliculus; organic anion transmembrane transporter activity; prostaglandin transport; response to arsenic-containing substance; response to heat; response to methotrexate; response to oxidative stress; thyroid hormone transport" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Canalicular multispecific organic anion transporter 1 (ATP-binding cassette sub-family C member 2) (Canalicular multidrug resistance protein) (Multidrug resistance-associated protein 2) ABCC2 CMOAT CMOAT1 CMRP MRP2 Homo sapiens (Human) TR36997_c1_g1_i1 Q5RCQ5 MFS11_PONAB 3.00E-126 GO:0016021 integral to membrane IPR010291; IPR016196; UNC93-like protein MFSD11 (Major facilitator superfamily domain-containing protein 11) MFSD11 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36997_c1_g1_i3 A2VE54 UN93A_BOVIN 6.00E-10 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR010291; IPR016196; Protein unc-93 homolog A (Unc-93A) UNC93A Bos taurus (Bovine) TR36999_c1_g1_i2 A2BD94 FB31B_XENLA 6.00E-48 GO:0019005; GO:0031146; GO:0008054; GO:0031571; GO:0016567 SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cyclin catabolic process; mitotic G1 DNA damage checkpoint; protein ubiquitination IPR001810; IPR026941; Protein modification; protein ubiquitination. F-box only protein 31-B fbxo31-b Xenopus laevis (African clawed frog) TR36999_c1_g1_i6 Q3TQF0 FBX31_MOUSE 2.00E-48 GO:0019005; GO:0031146; GO:0008054; GO:0031571; GO:0016567 SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cyclin catabolic process; mitotic G1 DNA damage checkpoint; protein ubiquitination IPR001810; IPR026941; Protein modification; protein ubiquitination. F-box only protein 31 Fbxo31 MNCb-2609 Mus musculus (Mouse) TR37000_c0_g1_i1 P26221 GUN4_THEFU 5.00E-60 GO:0008810; GO:0030248; GO:0030245 cellulase activity; cellulose binding; cellulose catabolic process IPR008928; IPR012341; IPR008965; IPR001956; IPR012291; IPR018366; IPR001919; IPR003961; IPR001701; IPR018221; IPR013783; Glycan metabolism; cellulose degradation. "Endoglucanase E-4 (EC 3.2.1.4) (Cellulase E-4) (Cellulase E4) (Endo-1,4-beta-glucanase E-4)" celD Thermobifida fusca (Thermomonospora fusca) TR37000_c0_g1_i2 Q6YXT7 GUN19_ORYSJ 3.00E-29 GO:0008810; GO:0030245; GO:0005576 cellulase activity; cellulose catabolic process; extracellular region IPR008928; IPR012341; IPR001701; IPR018221; "Endoglucanase 19 (EC 3.2.1.4) (Endo-1,4-beta glucanase 19)" Os08g0114200 LOC_Os08g02220 P0427G12.14 Oryza sativa subsp. japonica (Rice) TR37002_c4_g2_i1 Q9D4H8 CUL2_MOUSE 0 GO:0031462; GO:0030163; GO:0016567; GO:0006511 Cul2-RING ubiquitin ligase complex; protein catabolic process; protein ubiquitination; ubiquitin-dependent protein catabolic process IPR016157; IPR016158; IPR001373; IPR019559; IPR016159; IPR011991; Protein modification; protein ubiquitination. Cullin-2 (CUL-2) Cul2 Mus musculus (Mouse) TR37002_c4_g2_i2 Q17390 CUL2_CAEEL 0 GO:0008595; GO:0008105; GO:0030261; GO:0031461; GO:0008054; GO:0005737; GO:0042078; GO:0007138; GO:0051232; GO:0007067; GO:0005634; GO:0016567; GO:0051759 Q9BKS1; Q2WF59; P21541 "anterior/posterior axis specification, embryo; asymmetric protein localization; chromosome condensation; cullin-RING ubiquitin ligase complex; cyclin catabolic process; cytoplasm; germ-line stem cell division; meiotic anaphase II; meiotic spindle elongation; mitosis; nucleus; protein ubiquitination; sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation" IPR016157; IPR016158; IPR001373; IPR019559; IPR016159; IPR011991; Protein modification; protein ubiquitination. Cullin-2 (CUL-2) cul-2 ZK520.4 Caenorhabditis elegans TR37002_c4_g2_i4 Q9D4H8 CUL2_MOUSE 0 GO:0031462; GO:0030163; GO:0016567; GO:0006511 Cul2-RING ubiquitin ligase complex; protein catabolic process; protein ubiquitination; ubiquitin-dependent protein catabolic process IPR016157; IPR016158; IPR001373; IPR019559; IPR016159; IPR011991; Protein modification; protein ubiquitination. Cullin-2 (CUL-2) Cul2 Mus musculus (Mouse) TR37005_c3_g1_i3 Q5UAW9 GP157_HUMAN 7.00E-18 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR022343; IPR017981; IPR000832; IPR017452; Probable G-protein coupled receptor 157 GPR157 Homo sapiens (Human) TR37005_c3_g1_i5 Q5UAW9 GP157_HUMAN 6.00E-18 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR022343; IPR017981; IPR000832; IPR017452; Probable G-protein coupled receptor 157 GPR157 Homo sapiens (Human) TR3701_c0_g1_i1 Q8TAB3 PCD19_HUMAN 1.00E-17 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR013164; Protocadherin-19 PCDH19 KIAA1313 Homo sapiens (Human) TR37010_c0_g1_i1 P54453 YQEH_BACSU 2.00E-19 GO:0005525; GO:0003924; GO:0005739; GO:0032297; GO:0042254 GTP binding; GTPase activity; mitochondrion; negative regulation of DNA-dependent DNA replication initiation; ribosome biogenesis IPR019988; IPR006073; IPR027417; Uncharacterized protein YqeH yqeH BSU25670 Bacillus subtilis (strain 168) TR37010_c0_g1_i2 Q8NC60 NOA1_HUMAN 5.00E-98 GO:0005525; GO:0003924; GO:0006915; GO:0005743; GO:0032543; GO:0010941; GO:0043457; GO:0042254 P51398; Q16795 GTP binding; GTPase activity; apoptotic process; mitochondrial inner membrane; mitochondrial translation; regulation of cell death; regulation of cellular respiration; ribosome biogenesis IPR006073; IPR027417; Nitric oxide-associated protein 1 NOA1 C4orf14 Homo sapiens (Human) TR37010_c0_g1_i3 Q9JJG9 NOA1_MOUSE 7.00E-91 GO:0005525; GO:0003924; GO:0006915; GO:0031314; GO:0005743; GO:0032543; GO:0010941; GO:0043457; GO:0042254 GTP binding; GTPase activity; apoptotic process; extrinsic to mitochondrial inner membrane; mitochondrial inner membrane; mitochondrial translation; regulation of cell death; regulation of cellular respiration; ribosome biogenesis IPR006073; IPR027417; Nitric oxide-associated protein 1 Noa1 MNCb-4931 Mus musculus (Mouse) TR37011_c0_g1_i1 H2A0M0 NRP_PINMG 5.00E-12 GO:0005576 extracellular region IPR008985; Asparagine-rich protein (Prism uncharacterized shell protein 1) (PUSP1) Pinctada margaritifera (Black-lipped pearl oyster) TR37011_c0_g1_i2 H2A0M0 NRP_PINMG 4.00E-12 GO:0005576 extracellular region IPR008985; Asparagine-rich protein (Prism uncharacterized shell protein 1) (PUSP1) Pinctada margaritifera (Black-lipped pearl oyster) TR37014_c0_g2_i2 Q8K370 ACD10_MOUSE 1.00E-18 GO:0003995; GO:0050660; GO:0016787; GO:0005739; GO:0016772 "acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; hydrolase activity; mitochondrion; transferase activity, transferring phosphorus-containing groups" IPR006091; IPR009075; IPR013786; IPR009100; IPR002575; IPR023214; IPR006439; IPR011945; IPR011009; IPR023198; Acyl-CoA dehydrogenase family member 10 (ACAD-10) (EC 1.3.99.-) Acad10 Mus musculus (Mouse) TR37014_c0_g2_i3 P45954 ACDSB_HUMAN 0 GO:0003995; GO:0009083; GO:0034641; GO:0006631; GO:0050660; GO:0005759 acyl-CoA dehydrogenase activity; branched-chain amino acid catabolic process; cellular nitrogen compound metabolic process; fatty acid metabolic process; flavin adenine dinucleotide binding; mitochondrial matrix IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Lipid metabolism; mitochondrial fatty acid beta-oxidation. "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (SBCAD) (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-MEBCAD) (2-methylbutyryl-coenzyme A dehydrogenase) (2-methylbutyryl-CoA dehydrogenase)" ACADSB Homo sapiens (Human) TR37014_c0_g2_i7 P45954 ACDSB_HUMAN 0 GO:0003995; GO:0009083; GO:0034641; GO:0006631; GO:0050660; GO:0005759 acyl-CoA dehydrogenase activity; branched-chain amino acid catabolic process; cellular nitrogen compound metabolic process; fatty acid metabolic process; flavin adenine dinucleotide binding; mitochondrial matrix IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Lipid metabolism; mitochondrial fatty acid beta-oxidation. "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (SBCAD) (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-MEBCAD) (2-methylbutyryl-coenzyme A dehydrogenase) (2-methylbutyryl-CoA dehydrogenase)" ACADSB Homo sapiens (Human) TR37016_c2_g1_i1 P55918 MFAP4_BOVIN 5.00E-69 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR014716; IPR014715; IPR002181; Microfibril-associated glycoprotein 4 (36 kDa microfibril-associated glycoprotein) (36 kDa MAP) MFAP4 Bos taurus (Bovine) TR37016_c2_g1_i2 Q80YX1 TENA_MOUSE 9.00E-53 GO:0005604; GO:0007155; GO:0005615; GO:0005614; GO:0060739; GO:0007528; GO:0014012; GO:0008284; GO:0010628; GO:0060740; GO:0045545 basement membrane; cell adhesion; extracellular space; interstitial matrix; mesenchymal-epithelial cell signaling involved in prostate gland development; neuromuscular junction development; peripheral nervous system axon regeneration; positive regulation of cell proliferation; positive regulation of gene expression; prostate gland epithelium morphogenesis; syndecan binding IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin (TN) (Hexabrachion) (Tenascin-C) (TN-C) Tnc Hxb Mus musculus (Mouse) TR37016_c2_g1_i6 Q8N539 FBCD1_HUMAN 5.00E-71 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 UNQ701/PRO1346 Homo sapiens (Human) TR37017_c0_g1_i1 Q04336 YM54_YEAST 0 GO:0003824; GO:0008152 catalytic activity; metabolic process IPR008928; Uncharacterized protein YMR196W YMR196W YM9646.09 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR37017_c0_g2_i1 Q04336 YM54_YEAST 2.00E-36 GO:0003824; GO:0008152 catalytic activity; metabolic process IPR008928; Uncharacterized protein YMR196W YMR196W YM9646.09 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR37019_c0_g2_i1 Q6NRY2 NOL6_XENLA 0 GO:0003723; GO:0005730 RNA binding; nucleolus IPR005554; Nucleolar protein 6 nol6 Xenopus laevis (African clawed frog) TR37020_c3_g1_i1 Q8T3C8 MTFP1_CAEEL 5.00E-53 GO:0006915; GO:0016021; GO:0005743 apoptotic process; integral to membrane; mitochondrial inner membrane IPR019560; Mitochondrial fission process protein 1 (Mitochondrial 18 kDa protein) (MTP18) mtp-18 T13C5.8 Caenorhabditis elegans TR37021_c2_g1_i1 P98077 SHC2_HUMAN 3.00E-58 GO:0007265; GO:0005829; GO:0008286; GO:0048011 P00533; P04626 Ras protein signal transduction; cytosol; insulin receptor signaling pathway; neurotrophin TRK receptor signaling pathway IPR011993; IPR006019; IPR006020; IPR000980; SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) SHC2 SCK SHCB Homo sapiens (Human) TR37021_c2_g3_i1 P16591 FER_HUMAN 2.00E-11 GO:0005524; GO:0038095; GO:0038109; GO:0031532; GO:0005938; GO:0030054; GO:0042995; GO:0008283; GO:0044331; GO:0036006; GO:0034614; GO:0006935; GO:0005856; GO:0005829; GO:0050904; GO:0005154; GO:0035426; GO:0031234; GO:0038028; GO:0070102; GO:0008289; GO:0000226; GO:0000278; GO:0033007; GO:0004715; GO:0005634; GO:0048008; GO:0051092; GO:0030838; GO:0030335; GO:0008284; GO:0046777; GO:0042058; GO:0010762; GO:0010591; GO:0001932; GO:0032496; GO:0036119; GO:0034446; GO:0042503 O42486 ATP binding; Fc-epsilon receptor signaling pathway; Kit signaling pathway; actin cytoskeleton reorganization; cell cortex; cell junction; cell projection; cell proliferation; cell-cell adhesion mediated by cadherin; cellular response to macrophage colony-stimulating factor stimulus; cellular response to reactive oxygen species; chemotaxis; cytoskeleton; cytosol; diapedesis; epidermal growth factor receptor binding; extracellular matrix-cell signaling; extrinsic to internal side of plasma membrane; insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade; interleukin-6-mediated signaling pathway; lipid binding; microtubule cytoskeleton organization; mitotic cell cycle; negative regulation of mast cell activation involved in immune response; non-membrane spanning protein tyrosine kinase activity; nucleus; platelet-derived growth factor receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; positive regulation of actin filament polymerization; positive regulation of cell migration; positive regulation of cell proliferation; protein autophosphorylation; regulation of epidermal growth factor receptor signaling pathway; regulation of fibroblast migration; regulation of lamellipodium assembly; regulation of protein phosphorylation; response to lipopolysaccharide; response to platelet-derived growth factor stimulus; substrate adhesion-dependent cell spreading; tyrosine phosphorylation of Stat3 protein IPR001060; IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR008266; IPR020635; IPR016250; Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer) FER TYK3 Homo sapiens (Human) TR37022_c0_g1_i1 P98133 FBN1_BOVIN 2.00E-46 GO:0005509; GO:0005201; GO:0005578 calcium ion binding; extracellular matrix structural constituent; proteinaceous extracellular matrix IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR011398; IPR009030; IPR017878; Fibrillin-1 (MP340) FBN1 Bos taurus (Bovine) TR37022_c0_g2_i1 P98133 FBN1_BOVIN 6.00E-36 GO:0005509; GO:0005201; GO:0005578 calcium ion binding; extracellular matrix structural constituent; proteinaceous extracellular matrix IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR011398; IPR009030; IPR017878; Fibrillin-1 (MP340) FBN1 Bos taurus (Bovine) TR37024_c0_g1_i1 Q3ZBR5 TTC1_BOVIN 6.00E-57 GO:0005778 peroxisomal membrane IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 1 (TPR repeat protein 1) TTC1 Bos taurus (Bovine) TR37024_c0_g1_i3 Q3ZBR5 TTC1_BOVIN 4.00E-57 GO:0005778 peroxisomal membrane IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 1 (TPR repeat protein 1) TTC1 Bos taurus (Bovine) TR37024_c0_g1_i4 Q5U2X2 SPAG1_RAT 3.00E-14 GO:0005525; GO:0005737; GO:0016787; GO:0007338 GTP binding; cytoplasm; hydrolase activity; single fertilization IPR025986; IPR013026; IPR011990; IPR001440; IPR019734; Sperm-associated antigen 1 (HSD-3.8) (Infertility-related sperm protein Spag-1) Spag1 Rattus norvegicus (Rat) TR37024_c0_g1_i5 Q6DGE9 UN45B_DANRE 6.00E-15 GO:0030018; GO:0048738; GO:0030239; GO:0048471; GO:0007519 Z disc; cardiac muscle tissue development; myofibril assembly; perinuclear region of cytoplasm; skeletal muscle tissue development IPR011989; IPR016024; IPR013026; IPR011990; IPR001440; IPR019734; IPR024660; Protein unc-45 homolog B (Unc-45B) (UNC45-related protein) unc45b unc45r si:ch211-204d2.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR37024_c0_g1_i6 Q80ZX8 SPAG1_MOUSE 4.00E-16 GO:0005525; GO:0005737; GO:0016787; GO:0007338 GTP binding; cytoplasm; hydrolase activity; single fertilization IPR025986; IPR013026; IPR011990; IPR001440; IPR019734; Sperm-associated antigen 1 (Infertility-related sperm protein Spag-1) (TPR-containing protein involved in spermatogenesis) (TPIS) Spag1 Tpis Mus musculus (Mouse) TR37028_c1_g2_i1 P00889 CISY_PIG 0 GO:0005975; GO:0044262; GO:0004108; GO:0005759; GO:0006099 carbohydrate metabolic process; cellular carbohydrate metabolic process; citrate (Si)-synthase activity; mitochondrial matrix; tricarboxylic acid cycle IPR016142; IPR002020; IPR016141; IPR019810; IPR010109; Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2. "Citrate synthase, mitochondrial (EC 2.3.3.1)" CS Sus scrofa (Pig) TR37028_c2_g1_i1 P00523 SRC_CHICK 0 GO:0005524; GO:0045453; GO:0060444; GO:0005901; GO:0007155; GO:0007049; GO:0016477; GO:0005856; GO:0010008; GO:0030900; GO:0020037; GO:0007243; GO:0005770; GO:0005764; GO:0005743; GO:2000811; GO:0043154; GO:2001237; GO:2001243; GO:0032463; GO:0004715; GO:0005634; GO:0048477; GO:0070374; GO:0090263; GO:0071803; GO:0051897; GO:0046777; GO:0033146; GO:0043393; GO:0070555; GO:0060065 Q90738; Q9QWY8-1; Q9QWY8-2; Q9NZA1; P41240; Q9Y4D1; O88703; Q00944; P18433; P18052; Q9QWI6-2 ATP binding; bone resorption; branching involved in mammary gland duct morphogenesis; caveola; cell adhesion; cell cycle; cell migration; cytoskeleton; endosome membrane; forebrain development; heme binding; intracellular protein kinase cascade; late endosome; lysosome; mitochondrial inner membrane; negative regulation of anoikis; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of protein homooligomerization; non-membrane spanning protein tyrosine kinase activity; nucleus; oogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of podosome assembly; positive regulation of protein kinase B signaling cascade; protein autophosphorylation; regulation of intracellular estrogen receptor signaling pathway; regulation of protein binding; response to interleukin-1; uterus development IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) SRC Gallus gallus (Chicken) TR37028_c2_g1_i2 Q1JPZ3 SRC_DANRE 0 GO:0005524; GO:0007155; GO:0007049; GO:0005856; GO:0005743; GO:0004715; GO:0005634; GO:0018108; GO:0005886 ATP binding; cell adhesion; cell cycle; cytoskeleton; mitochondrial inner membrane; non-membrane spanning protein tyrosine kinase activity; nucleus; peptidyl-tyrosine phosphorylation; plasma membrane IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) src Danio rerio (Zebrafish) (Brachydanio rerio) TR37028_c2_g1_i4 P00523 SRC_CHICK 0 GO:0005524; GO:0045453; GO:0060444; GO:0005901; GO:0007155; GO:0007049; GO:0016477; GO:0005856; GO:0010008; GO:0030900; GO:0020037; GO:0007243; GO:0005770; GO:0005764; GO:0005743; GO:2000811; GO:0043154; GO:2001237; GO:2001243; GO:0032463; GO:0004715; GO:0005634; GO:0048477; GO:0070374; GO:0090263; GO:0071803; GO:0051897; GO:0046777; GO:0033146; GO:0043393; GO:0070555; GO:0060065 Q90738; Q9QWY8-1; Q9QWY8-2; Q9NZA1; P41240; Q9Y4D1; O88703; Q00944; P18433; P18052; Q9QWI6-2 ATP binding; bone resorption; branching involved in mammary gland duct morphogenesis; caveola; cell adhesion; cell cycle; cell migration; cytoskeleton; endosome membrane; forebrain development; heme binding; intracellular protein kinase cascade; late endosome; lysosome; mitochondrial inner membrane; negative regulation of anoikis; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of protein homooligomerization; non-membrane spanning protein tyrosine kinase activity; nucleus; oogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of podosome assembly; positive regulation of protein kinase B signaling cascade; protein autophosphorylation; regulation of intracellular estrogen receptor signaling pathway; regulation of protein binding; response to interleukin-1; uterus development IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) SRC Gallus gallus (Chicken) TR37028_c2_g1_i5 Q03351 NTRK3_RAT 2.00E-43 GO:0005524; GO:0000139; GO:0000187; GO:0032856; GO:0032148; GO:0071300; GO:0090102; GO:0005887; GO:0042490; GO:0019056; GO:0048712; GO:0060548; GO:0001933; GO:0048665; GO:0001764; GO:0005030; GO:0018108; GO:0005886; GO:2000251; GO:0048691; GO:0030335; GO:0008284; GO:0010628; GO:0033138; GO:0050927; GO:0046777; GO:0048678; GO:0051412; GO:0045471; GO:0004714; GO:0007169 ATP binding; Golgi membrane; activation of MAPK activity; activation of Ras GTPase activity; activation of protein kinase B activity; cellular response to retinoic acid; cochlea development; integral to plasma membrane; mechanoreceptor differentiation; modulation by virus of host transcription; negative regulation of astrocyte differentiation; negative regulation of cell death; negative regulation of protein phosphorylation; neuron fate specification; neuron migration; neurotrophin receptor activity; peptidyl-tyrosine phosphorylation; plasma membrane; positive regulation of actin cytoskeleton reorganization; positive regulation of axon extension involved in regeneration; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; positive regulation of positive chemotaxis; protein autophosphorylation; response to axon injury; response to corticosterone stimulus; response to ethanol; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000483; IPR007110; IPR013783; IPR013098; IPR003599; IPR011009; IPR001611; IPR000372; IPR000719; IPR017441; IPR001245; IPR020446; IPR008266; IPR020635; IPR020777; IPR002011; NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) Ntrk3 Trkc Rattus norvegicus (Rat) TR37028_c2_g1_i6 Q1JPZ3 SRC_DANRE 0 GO:0005524; GO:0007155; GO:0007049; GO:0005856; GO:0005743; GO:0004715; GO:0005634; GO:0018108; GO:0005886 ATP binding; cell adhesion; cell cycle; cytoskeleton; mitochondrial inner membrane; non-membrane spanning protein tyrosine kinase activity; nucleus; peptidyl-tyrosine phosphorylation; plasma membrane IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) src Danio rerio (Zebrafish) (Brachydanio rerio) TR37028_c2_g1_i7 P00523 SRC_CHICK 0 GO:0005524; GO:0045453; GO:0060444; GO:0005901; GO:0007155; GO:0007049; GO:0016477; GO:0005856; GO:0010008; GO:0030900; GO:0020037; GO:0007243; GO:0005770; GO:0005764; GO:0005743; GO:2000811; GO:0043154; GO:2001237; GO:2001243; GO:0032463; GO:0004715; GO:0005634; GO:0048477; GO:0070374; GO:0090263; GO:0071803; GO:0051897; GO:0046777; GO:0033146; GO:0043393; GO:0070555; GO:0060065 Q90738; Q9QWY8-1; Q9QWY8-2; Q9NZA1; P41240; Q9Y4D1; O88703; Q00944; P18433; P18052; Q9QWI6-2 ATP binding; bone resorption; branching involved in mammary gland duct morphogenesis; caveola; cell adhesion; cell cycle; cell migration; cytoskeleton; endosome membrane; forebrain development; heme binding; intracellular protein kinase cascade; late endosome; lysosome; mitochondrial inner membrane; negative regulation of anoikis; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of protein homooligomerization; non-membrane spanning protein tyrosine kinase activity; nucleus; oogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of podosome assembly; positive regulation of protein kinase B signaling cascade; protein autophosphorylation; regulation of intracellular estrogen receptor signaling pathway; regulation of protein binding; response to interleukin-1; uterus development IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) SRC Gallus gallus (Chicken) TR37029_c2_g1_i3 Q9DAN9 CQ105_MOUSE 8.00E-18 Uncharacterized protein C17orf105 homolog Mus musculus (Mouse) TR37029_c2_g1_i7 Q9DAN9 CQ105_MOUSE 8.00E-18 Uncharacterized protein C17orf105 homolog Mus musculus (Mouse) TR37030_c0_g1_i2 Q9IB61 BLCAP_DANRE 8.00E-29 GO:0016021 integral to membrane IPR009598; IPR018015; Bladder cancer-associated protein (ZfBc10) blcap zgc:73246 Danio rerio (Zebrafish) (Brachydanio rerio) TR37031_c3_g1_i1 P57722 PCBP3_MOUSE 4.00E-60 GO:0003677; GO:0003723; GO:0005829; GO:0005739; GO:0005634; GO:0030529 DNA binding; RNA binding; cytosol; mitochondrion; nucleus; ribonucleoprotein complex IPR004087; IPR004088; Poly(rC)-binding protein 3 (Alpha-CP3) Pcbp3 Mus musculus (Mouse) TR37031_c3_g1_i3 P57724 PCBP4_MOUSE 4.00E-50 GO:0003677; GO:0003723; GO:0005737; GO:0030529 DNA binding; RNA binding; cytoplasm; ribonucleoprotein complex IPR004087; IPR004088; Poly(rC)-binding protein 4 (Alpha-CP4) Pcbp4 Mus musculus (Mouse) TR37031_c3_g3_i3 Q9UNW9 NOVA2_HUMAN 9.00E-10 GO:0003723; GO:0005634 RNA binding; nucleus IPR004087; IPR004088; RNA-binding protein Nova-2 (Astrocytic NOVA1-like RNA-binding protein) (Neuro-oncological ventral antigen 2) NOVA2 ANOVA NOVA3 Homo sapiens (Human) TR37031_c3_g3_i5 Q8UVD9 FUBP2_CHICK 8.00E-10 GO:0005737; GO:0008298; GO:0003730; GO:0051028; GO:0005634 cytoplasm; intracellular mRNA localization; mRNA 3'-UTR binding; mRNA transport; nucleus IPR015096; IPR004087; IPR004088; Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (Zipcode-binding protein 2) KHSRP FUBP2 ZPB2 Gallus gallus (Chicken) TR37031_c3_g3_i7 P51513 NOVA1_HUMAN 2.00E-11 GO:0003723; GO:0008380; GO:0007626; GO:0003729; GO:0000398; GO:0005634; GO:0007268 "RNA binding; RNA splicing; locomotory behavior; mRNA binding; mRNA splicing, via spliceosome; nucleus; synaptic transmission" IPR004087; IPR004088; RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Onconeural ventral antigen 1) (Paraneoplastic Ri antigen) (Ventral neuron-specific protein 1) NOVA1 Homo sapiens (Human) TR37032_c2_g2_i1 P51112 HD_TAKRU 0 GO:0005737; GO:0005634; GO:0048513; GO:0008134 cytoplasm; nucleus; organ development; transcription factor binding IPR011989; IPR016024; IPR021133; IPR000091; IPR024613; Huntingtin (Huntington disease protein homolog) (HD protein homolog) htt hd Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR37033_c0_g2_i1 Q8WPA2 AR_BOMMO 1.00E-06 GO:0004930; GO:0042562; GO:0016021; GO:0042923; GO:0005886 G-protein coupled receptor activity; hormone binding; integral to membrane; neuropeptide binding; plasma membrane IPR000405; IPR000276; IPR017452; Allatostatin-A receptor (BAR) AR Bombyx mori (Silk moth) TR37033_c0_g2_i2 P32303 AGTRA_XENLA 5.00E-08 GO:0001595; GO:0004945; GO:0019722; GO:0051482; GO:0016021; GO:0005886; GO:0019229 angiotensin receptor activity; angiotensin type II receptor activity; calcium-mediated signaling; elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; integral to membrane; plasma membrane; regulation of vasoconstriction IPR000190; IPR000248; IPR000276; IPR017452; "Type-1 angiotensin II receptor A (xAT) (Angiotensin 2 receptor, type 1-A) (Angiotensin II receptor, type 1-A)" agtr1-a Xenopus laevis (African clawed frog) TR37033_c0_g2_i4 P30731 GPR83_MOUSE 2.00E-07 GO:0016021; GO:0004983; GO:0005886; GO:0051384 integral to membrane; neuropeptide Y receptor activity; plasma membrane; response to glucocorticoid stimulus IPR000276; IPR017452; IPR000611; Probable G-protein coupled receptor 83 (Glucocorticoid-induced receptor) Gpr83 Gir Gpr72 Mus musculus (Mouse) TR37034_c3_g1_i1 P53751 YN94_YEAST 3.00E-20 GO:0016021 integral to membrane IPR011040; IPR006581; Uncharacterized membrane glycoprotein YNR065C YNR065C N3539 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR37034_c3_g1_i2 Q6PHU5 SORT_MOUSE 2.00E-129 GO:0032580; GO:0006895; GO:0009986; GO:0005905; GO:0005769; GO:0006897; GO:0005789; GO:0010008; GO:0008333; GO:0032509; GO:0008625; GO:0046323; GO:0016021; GO:0005765; GO:0007275; GO:0014902; GO:0051005; GO:0010465; GO:0007218; GO:0030379; GO:0048011; GO:0031965; GO:0001503; GO:0048471; GO:0005886; GO:0048227; GO:0010468; GO:0032868; GO:0030140; GO:0016050 Q8CJ26 "Golgi cisterna membrane; Golgi to endosome transport; cell surface; coated pit; early endosome; endocytosis; endoplasmic reticulum membrane; endosome membrane; endosome to lysosome transport; endosome transport via multivesicular body sorting pathway; extrinsic apoptotic signaling pathway via death domain receptors; glucose import; integral to membrane; lysosomal membrane; multicellular organismal development; myotube differentiation; negative regulation of lipoprotein lipase activity; nerve growth factor receptor activity; neuropeptide signaling pathway; neurotensin receptor activity, non-G-protein coupled; neurotrophin TRK receptor signaling pathway; nuclear membrane; ossification; perinuclear region of cytoplasm; plasma membrane; plasma membrane to endosome transport; regulation of gene expression; response to insulin stimulus; trans-Golgi network transport vesicle; vesicle organization" IPR006581; Sortilin (Neurotensin receptor 3) (NTR3) (mNTR3) Sort1 Mus musculus (Mouse) TR37037_c4_g1_i1 A6X8Z5 RHG31_MOUSE 3.00E-86 GO:0005096; GO:0017124; GO:0005925; GO:0005622; GO:0030027; GO:0007264 Q9Z0R4 GTPase activator activity; SH3 domain binding; focal adhesion; intracellular; lamellipodium; small GTPase mediated signal transduction IPR008936; IPR000198; Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) Arhgap31 Cdgap Kiaa1204 Mus musculus (Mouse) TR37037_c4_g1_i2 Q6GPD0 RHG32_XENLA 6.00E-162 GO:0005096; GO:0005737; GO:0035091; GO:0005886; GO:0043547; GO:0007165 GTPase activator activity; cytoplasm; phosphatidylinositol binding; plasma membrane; positive regulation of GTPase activity; signal transduction IPR001683; IPR008936; IPR000198; IPR011511; IPR001452; Rho GTPase-activating protein 32 (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) arhgap32 rics Xenopus laevis (African clawed frog) TR37039_c2_g2_i1 Q8JFP1 IF4A2_CHICK 0 GO:0005524; GO:0008026; GO:0003743 ATP binding; ATP-dependent helicase activity; translation initiation factor activity IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) EIF4A2 RCJMB04_14a6 Gallus gallus (Chicken) TR3704_c0_g1_i1 Q7Z478 DHX29_HUMAN 4.00E-29 GO:0005524; GO:0008026; GO:0016282; GO:0005739; GO:0043024; GO:0003743 ATP binding; ATP-dependent helicase activity; eukaryotic 43S preinitiation complex; mitochondrion; ribosomal small subunit binding; translation initiation factor activity IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; ATP-dependent RNA helicase DHX29 (EC 3.6.4.13) (DEAH box protein 29) (Nucleic acid helicase DDXx) DHX29 DDX29 Homo sapiens (Human) TR37041_c3_g3_i1 Q6GQ69 FAF2B_XENLA 2.00E-06 GO:0005783; GO:0005811 endoplasmic reticulum; lipid particle IPR012336; IPR006577; IPR009060; IPR001012; FAS-associated factor 2-B (UBX domain-containing protein 8-B) faf2-b ubxd8-b Xenopus laevis (African clawed frog) TR37041_c3_g3_i2 Q9QZ49 UBXN8_MOUSE 2.00E-13 GO:0030433; GO:0030176 ER-associated protein catabolic process; integral to endoplasmic reticulum membrane IPR001012; IPR017247; UBX domain-containing protein 8 (Reproduction 8 protein) (Rep-8 protein) (UBX domain-containing protein 6) Ubxn8 D0H8S2298E Rep8 Ubxd6 Mus musculus (Mouse) TR37041_c4_g1_i3 Q2KJF9 T2EB_BOVIN 2.00E-76 GO:0003677; GO:0006355; GO:0005673; GO:0006367 "DNA binding; regulation of transcription, DNA-dependent; transcription factor TFIIE complex; transcription initiation from RNA polymerase II promoter" IPR016656; IPR003166; IPR011991; General transcription factor IIE subunit 2 (Transcription initiation factor IIE subunit beta) (TFIIE-beta) GTF2E2 Bos taurus (Bovine) TR37043_c1_g1_i1 Q7KU24 CHD1_DROME 8.00E-57 GO:0005524; GO:0008026; GO:0003677; GO:0003682; GO:0035042; GO:0004386; GO:0007476; GO:0005634; GO:0048477; GO:0005705; GO:0005703; GO:0006355; GO:0006351 "ATP binding; ATP-dependent helicase activity; DNA binding; chromatin binding; fertilization, exchange of chromosomal proteins; helicase activity; imaginal disc-derived wing morphogenesis; nucleus; oogenesis; polytene chromosome interband; polytene chromosome puff; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR023780; IPR000953; IPR016197; IPR023779; IPR002464; IPR025260; IPR014001; IPR001650; IPR027417; IPR000330; Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase Chd1) Chd1 CG3733 Drosophila melanogaster (Fruit fly) TR37043_c3_g1_i1 Q921N6 DDX27_MOUSE 0 GO:0005524; GO:0008026; GO:0003676; GO:0005634 ATP binding; ATP-dependent helicase activity; nucleic acid binding; nucleus IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX27 (EC 3.6.4.13) (DEAD box protein 27) Ddx27 Mus musculus (Mouse) TR37043_c4_g1_i1 B6ZLK2 CHD1_CHICK 2.00E-137 GO:0005524; GO:0003677; GO:0000775; GO:0004386; GO:0005634; GO:0006355; GO:0006351 "ATP binding; DNA binding; chromosome, centromeric region; helicase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR023780; IPR000953; IPR016197; IPR023779; IPR025260; IPR014001; IPR001650; IPR027417; IPR000330; Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase CHD1) CHD1 Gallus gallus (Chicken) TR37044_c2_g1_i1 Q9LGV5 CIPK1_ORYSJ 4.00E-51 GO:0005524; GO:0004674; GO:0007165 ATP binding; protein serine/threonine kinase activity; signal transduction IPR020636; IPR011009; IPR018451; IPR004041; IPR000719; IPR017441; IPR002290; IPR008271; CBL-interacting protein kinase 1 (EC 2.7.11.1) (OsCIPK01) CIPK1 Os01g0292200 LOC_Os01g18800 P0706B05.31 Oryza sativa subsp. japonica (Rice) TR37044_c2_g1_i3 A8WYE4 PAR1_CAEBR 2.00E-55 GO:0005524; GO:0005938; GO:0046872; GO:0007275; GO:0004674 ATP binding; cell cortex; metal ion binding; multicellular organismal development; protein serine/threonine kinase activity IPR028375; IPR001772; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR015940; Serine/threonine-protein kinase par-1 (EC 2.7.11.1) par-1 CBG04756 Caenorhabditis briggsae TR37044_c2_g1_i4 O88866 HUNK_MOUSE 1.00E-53 GO:0005524; GO:0004672; GO:0004674 ATP binding; protein kinase activity; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) Hunk Makv Mus musculus (Mouse) TR37044_c2_g1_i5 A8WYE4 PAR1_CAEBR 3.00E-55 GO:0005524; GO:0005938; GO:0046872; GO:0007275; GO:0004674 ATP binding; cell cortex; metal ion binding; multicellular organismal development; protein serine/threonine kinase activity IPR028375; IPR001772; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR015940; Serine/threonine-protein kinase par-1 (EC 2.7.11.1) par-1 CBG04756 Caenorhabditis briggsae TR37045_c8_g1_i2 Q99963 SH3G3_HUMAN 9.00E-120 GO:0007417; GO:0031901; GO:0006897; GO:0008289; GO:0007165 Itself; Q99700; P42858; Q99961; Q99962 central nervous system development; early endosome membrane; endocytosis; lipid binding; signal transduction IPR027267; IPR004148; IPR001452; Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3) SH3GL3 CNSA3 SH3D2C Homo sapiens (Human) TR37045_c8_g1_i3 Q62419 SH3G1_MOUSE 1.00E-117 GO:0030054; GO:0042995; GO:0031901; GO:0006897; GO:0008289; GO:0002102 P35545 cell junction; cell projection; early endosome membrane; endocytosis; lipid binding; podosome IPR027267; IPR004148; IPR001452; Endophilin-A2 (Endophilin-2) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) (SH3p8) Sh3gl1 Sh3d2b Mus musculus (Mouse) TR37046_c4_g1_i10 Q96RW7 HMCN1_HUMAN 1.00E-12 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR37046_c4_g1_i13 Q6MG64 VWA7_RAT 1.00E-15 GO:0005576 extracellular region IPR002035; von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 G7c Rattus norvegicus (Rat) TR37046_c4_g1_i3 Q8NDA2 HMCN2_HUMAN 1.00E-15 GO:0005509; GO:0005578; GO:0050896 calcium ion binding; proteinaceous extracellular matrix; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 HMCN2 Homo sapiens (Human) TR37046_c4_g1_i4 Q9JHA8 VWA7_MOUSE 3.00E-25 GO:0005576 extracellular region IPR002035; von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 D17h6s56e-3 G7c Mus musculus (Mouse) TR37046_c4_g1_i6 Q96RW7 HMCN1_HUMAN 1.00E-14 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR37049_c1_g1_i1 P69527 AMPO_RAT 7.00E-59 GO:0004177; GO:0005737; GO:0019370; GO:0008237; GO:0006508; GO:0008270 aminopeptidase activity; cytoplasm; leukotriene biosynthetic process; metallopeptidase activity; proteolysis; zinc ion binding IPR016024; IPR001930; IPR015211; IPR014782; Aminopeptidase O (AP-O) (EC 3.4.11.-) Aopep Onpep Rattus norvegicus (Rat) TR37049_c1_g2_i1 Q8VCT3 AMPB_MOUSE 6.00E-26 GO:0004177; GO:0005576; GO:0005615; GO:0019370; GO:0008237; GO:0005886; GO:0006508; GO:0008270 aminopeptidase activity; extracellular region; extracellular space; leukotriene biosynthetic process; metallopeptidase activity; plasma membrane; proteolysis; zinc ion binding IPR016024; IPR015571; IPR001930; IPR015211; IPR014782; Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) (Cytosol aminopeptidase IV) Rnpep Mus musculus (Mouse) TR37050_c3_g2_i1 P02460 CO2A1_CHICK 4.00E-37 GO:0005604; GO:0001502; GO:0060351; GO:0071773; GO:0007417; GO:0002062; GO:0030199; GO:0005585; GO:0005737; GO:0060272; GO:0001958; GO:0005201; GO:0005615; GO:0003007; GO:0042472; GO:0060174; GO:0046872; GO:0043066; GO:0030903; GO:0071599; GO:0060021; GO:0006029; GO:0010468; GO:0007605; GO:0001894; GO:0007601 basement membrane; cartilage condensation; cartilage development involved in endochondral bone morphogenesis; cellular response to BMP stimulus; central nervous system development; chondrocyte differentiation; collagen fibril organization; collagen type II; cytoplasm; embryonic skeletal joint morphogenesis; endochondral ossification; extracellular matrix structural constituent; extracellular space; heart morphogenesis; inner ear morphogenesis; limb bud formation; metal ion binding; negative regulation of apoptotic process; notochord development; otic vesicle development; palate development; proteoglycan metabolic process; regulation of gene expression; sensory perception of sound; tissue homeostasis; visual perception IPR008160; IPR000885; Collagen alpha-1(II) chain (Alpha-1 type II collagen) (Fragment) COL2A1 Gallus gallus (Chicken) TR37053_c1_g2_i1 Q5U4W1 LZTS2_XENLA 2.00E-17 GO:0016055; GO:0051301; GO:0005737; GO:0005874; GO:0005815; GO:0007067 Wnt receptor signaling pathway; cell division; cytoplasm; microtubule; microtubule organizing center; mitosis Leucine zipper putative tumor suppressor 2 homolog (Protein lapser1) lzts2 lapser1 Xenopus laevis (African clawed frog) TR37053_c1_g2_i2 Q5U4W1 LZTS2_XENLA 1.00E-17 GO:0016055; GO:0051301; GO:0005737; GO:0005874; GO:0005815; GO:0007067 Wnt receptor signaling pathway; cell division; cytoplasm; microtubule; microtubule organizing center; mitosis Leucine zipper putative tumor suppressor 2 homolog (Protein lapser1) lzts2 lapser1 Xenopus laevis (African clawed frog) TR37054_c0_g1_i1 Q8N4L8 CCD24_HUMAN 4.00E-19 Coiled-coil domain-containing protein 24 CCDC24 Homo sapiens (Human) TR37055_c0_g2_i1 Q5NVB9 ZDH13_PONAB 1.00E-129 GO:0030660; GO:0016021; GO:0015095; GO:0016409; GO:0008270 Golgi-associated vesicle membrane; integral to membrane; magnesium ion transmembrane transporter activity; palmitoyltransferase activity; zinc ion binding IPR002110; IPR020683; IPR001594; Palmitoyltransferase ZDHHC13 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) ZDHHC13 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37055_c0_g2_i2 Q8IUH5 ZDH17_HUMAN 2.00E-174 GO:0030660; GO:0016021; GO:0042953; GO:0015095; GO:0043123; GO:0018345; GO:0019706; GO:0004871; GO:0008270 P42858; P60880 Golgi-associated vesicle membrane; integral to membrane; lipoprotein transport; magnesium ion transmembrane transporter activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein palmitoylation; protein-cysteine S-palmitoyltransferase activity; signal transducer activity; zinc ion binding IPR002110; IPR020683; IPR001594; Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Huntingtin yeast partner H) (Huntingtin-interacting protein 14) (HIP-14) (Huntingtin-interacting protein 3) (HIP-3) (Huntingtin-interacting protein H) (Putative MAPK-activating protein PM11) (Putative NF-kappa-B-activating protein 205) (Zinc finger DHHC domain-containing protein 17) (DHHC-17) ZDHHC17 HIP14 HIP3 HYPH KIAA0946 HSPC294 Homo sapiens (Human) TR37058_c0_g1_i1 Q9D6K5 SYJ2B_MOUSE 3.00E-25 GO:0009986; GO:0006897; GO:0031307; GO:0048312; GO:0032926; GO:0048471; GO:0032927; GO:2000010; GO:0002092 A2ARV4 cell surface; endocytosis; integral to mitochondrial outer membrane; intracellular distribution of mitochondria; negative regulation of activin receptor signaling pathway; perinuclear region of cytoplasm; positive regulation of activin receptor signaling pathway; positive regulation of protein localization to cell surface; positive regulation of receptor internalization IPR001478; Synaptojanin-2-binding protein (Activin receptor-interacting protein 2) (Activin receptor-interacting protein 4) (Mitochondrial outer membrane protein 25) Synj2bp Arip2 Omp25 Mus musculus (Mouse) TR37058_c0_g1_i2 Q5PYH7 DLG2_DANRE 3.00E-15 GO:0010923; GO:0050808; GO:0007268 negative regulation of phosphatase activity; synapse organization; synaptic transmission IPR008145; IPR008144; IPR020590; IPR016313; IPR019590; IPR027417; IPR001478; IPR019583; IPR011511; IPR001452; Disks large homolog 2 (Postsynaptic density protein 93) (PSD-93) dlg2 Danio rerio (Zebrafish) (Brachydanio rerio) TR37058_c0_g1_i3 Q9D6K5 SYJ2B_MOUSE 7.00E-27 GO:0009986; GO:0006897; GO:0031307; GO:0048312; GO:0032926; GO:0048471; GO:0032927; GO:2000010; GO:0002092 A2ARV4 cell surface; endocytosis; integral to mitochondrial outer membrane; intracellular distribution of mitochondria; negative regulation of activin receptor signaling pathway; perinuclear region of cytoplasm; positive regulation of activin receptor signaling pathway; positive regulation of protein localization to cell surface; positive regulation of receptor internalization IPR001478; Synaptojanin-2-binding protein (Activin receptor-interacting protein 2) (Activin receptor-interacting protein 4) (Mitochondrial outer membrane protein 25) Synj2bp Arip2 Omp25 Mus musculus (Mouse) TR37058_c0_g1_i4 Q6NXB2 PDZ11_DANRE 1.00E-05 GO:0016323; GO:0005829; GO:0008022 basolateral plasma membrane; cytosol; protein C-terminus binding IPR001478; PDZ domain-containing protein 11 pdzd11 pdzk11 zgc:77536 Danio rerio (Zebrafish) (Brachydanio rerio) TR37059_c0_g2_i1 Q28BX9 K0528_XENTR 2.00E-41 GO:0005509; GO:0005544; GO:0005938; GO:0030659; GO:0038028; GO:0065002; GO:0010828; GO:0090314; GO:0031340; GO:0032587 calcium ion binding; calcium-dependent phospholipid binding; cell cortex; cytoplasmic vesicle membrane; insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade; intracellular protein transmembrane transport; positive regulation of glucose transport; positive regulation of protein targeting to membrane; positive regulation of vesicle fusion; ruffle membrane IPR000008; C2 domain-containing protein 5 (138 kDa C2 domain-containing phosphoprotein) c2cd5 TGas115n11.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37059_c1_g1_i1 Q8N6D5 ANR29_HUMAN 3.00E-15 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 29 ANKRD29 Homo sapiens (Human) TR3706_c0_g1_i1 O88563 MRP3_RAT 1.00E-36 GO:0005524; GO:0016323; GO:0015432; GO:0015722; GO:0016021; GO:0032355; GO:0032496; GO:0010243; GO:0008559 ATP binding; basolateral plasma membrane; bile acid-exporting ATPase activity; canalicular bile acid transport; integral to membrane; response to estradiol stimulus; response to lipopolysaccharide; response to organonitrogen compound; xenobiotic-transporting ATPase activity IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (MRP-like protein 2) (MLP-2) (Multidrug resistance-associated protein 3) Abcc3 Cmoat2 Mlp2 Mrp3 Rattus norvegicus (Rat) TR37060_c0_g1_i1 Q3T0Z7 DHPR_BOVIN 7.00E-92 GO:0004155; GO:0005737; GO:0006729 "6,7-dihydropteridine reductase activity; cytoplasm; tetrahydrobiopterin biosynthetic process" IPR002198; IPR016040; IPR020904; Dihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoid dihydropteridine reductase) QDPR Bos taurus (Bovine) TR37060_c0_g1_i4 Q3T0Z7 DHPR_BOVIN 1.00E-88 GO:0004155; GO:0005737; GO:0006729 "6,7-dihydropteridine reductase activity; cytoplasm; tetrahydrobiopterin biosynthetic process" IPR002198; IPR016040; IPR020904; Dihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoid dihydropteridine reductase) QDPR Bos taurus (Bovine) TR37061_c0_g1_i1 Q2KI24 MTHSD_BOVIN 1.00E-110 GO:0030272; GO:0005524; GO:0003723; GO:0009396 5-formyltetrahydrofolate cyclo-ligase activity; ATP binding; RNA binding; folic acid-containing compound biosynthetic process IPR002698; IPR024185; IPR012677; IPR000504; Methenyltetrahydrofolate synthase domain-containing protein MTHFSD Bos taurus (Bovine) TR37062_c4_g2_i2 Q9Y3D0 MIP18_HUMAN 2.00E-52 GO:0097361; GO:0071817; GO:0007059; GO:0005634; GO:0044281 CIA complex; MMXD complex; chromosome segregation; nucleus; small molecule metabolic process IPR002744; Mitotic spindle-associated MMXD complex subunit MIP18 (MSS19-interacting protein of 18 kDa) (Protein FAM96B) FAM96B MIP18 CGI-128 HSPC118 Homo sapiens (Human) TR37064_c1_g1_i1 P0CN94 GPN3_CRYNJ 6.00E-21 GO:0005525 GTP binding IPR027417; IPR004130; GPN-loop GTPase 3 homolog CNB04680 CNB04680 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR37064_c1_g1_i2 Q8VCE2 GPN1_MOUSE 8.00E-139 GO:0005525; GO:0005737; GO:0017111 GTP binding; cytoplasm; nucleoside-triphosphatase activity IPR003593; IPR027417; IPR004130; GPN-loop GTPase 1 (MBD2-interacting protein) (MBDin) (XPA-binding protein 1) Gpn1 Mbdin Xab1 Mus musculus (Mouse) TR37064_c1_g1_i3 Q9HCN4 GPN1_HUMAN 1.00E-143 GO:0005525; GO:0005737; GO:0043231; GO:0017111 GTP binding; cytoplasm; intracellular membrane-bounded organelle; nucleoside-triphosphatase activity IPR003593; IPR027417; IPR004130; GPN-loop GTPase 1 (MBD2-interacting protein) (MBDin) (XPA-binding protein 1) GPN1 MBDIN XAB1 HUSSY-23 Homo sapiens (Human) TR37066_c0_g4_i2 Q6NWF4 VPS25_DANRE 5.00E-41 GO:0005737; GO:0015031 cytoplasm; protein transport IPR008570; IPR014041; IPR011991; Vacuolar protein-sorting-associated protein 25 (ESCRT-II complex subunit VPS25) vps25 Danio rerio (Zebrafish) (Brachydanio rerio) TR37067_c0_g1_i1 Q9DCD2 SYF1_MOUSE 0 GO:0008380; GO:0001824; GO:0071013; GO:0006397; GO:0006351; GO:0006283 "RNA splicing; blastocyst development; catalytic step 2 spliceosome; mRNA processing; transcription, DNA-dependent; transcription-coupled nucleotide-excision repair" IPR003107; IPR013026; IPR011990; IPR013105; IPR019734; Pre-mRNA-splicing factor SYF1 (XPA-binding protein 2) Xab2 Syf1 Mus musculus (Mouse) TR37068_c0_g1_i1 O94805 ACL6B_HUMAN 0 GO:0016514; GO:0006338; GO:0071565; GO:0007399; GO:0005730; GO:0006357; GO:0005200; GO:0003713; GO:0006351 "SWI/SNF complex; chromatin remodeling; nBAF complex; nervous system development; nucleolus; regulation of transcription from RNA polymerase II promoter; structural constituent of cytoskeleton; transcription coactivator activity; transcription, DNA-dependent" IPR004000; IPR004001; Actin-like protein 6B (53 kDa BRG1-associated factor B) (Actin-related protein Baf53b) (ArpNalpha) (BRG1-associated factor 53B) (BAF53B) ACTL6B ACTL6 BAF53B Homo sapiens (Human) TR37069_c0_g1_i1 Q04073 P3A2_STRPU 2.00E-99 GO:0003677; GO:0005634; GO:0006355; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019526; IPR019525; DNA-binding protein P3A2 Strongylocentrotus purpuratus (Purple sea urchin) TR37069_c0_g1_i3 Q9WU00 NRF1_MOUSE 3.00E-97 GO:0003677; GO:0007005; GO:0005634; GO:0003700; GO:0005667; GO:0006351 "DNA binding; mitochondrion organization; nucleus; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent" IPR019526; IPR019525; Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal) Nrf1 Mus musculus (Mouse) TR37070_c0_g1_i1 Q6GNV7 DIRC2_XENLA 2.00E-83 GO:0016021; GO:0005765; GO:0055085 integral to membrane; lysosomal membrane; transmembrane transport IPR011701; IPR016196; Disrupted in renal carcinoma protein 2 homolog dirc2 Xenopus laevis (African clawed frog) TR37070_c0_g1_i3 Q9N1F2 FLVC1_FELCA 2.00E-23 GO:0043249; GO:0097037; GO:0015232; GO:0016021; GO:0006839; GO:0005739; GO:0005886; GO:0009615; GO:0055085; GO:0001618 erythrocyte maturation; heme export; heme transporter activity; integral to membrane; mitochondrial transport; mitochondrion; plasma membrane; response to virus; transmembrane transport; virus receptor activity IPR011701; IPR020846; IPR016196; Feline leukemia virus subgroup C receptor-related protein 1 FLVCR1 Felis catus (Cat) (Felis silvestris catus) TR37071_c1_g1_i1 Q63060 GLPK_RAT 0 GO:0005524; GO:0019563; GO:0004370; GO:0006072; GO:0042393; GO:0005741; GO:0005739; GO:0005634; GO:0009409; GO:0042493; GO:0045471 ATP binding; glycerol catabolic process; glycerol kinase activity; glycerol-3-phosphate metabolic process; histone binding; mitochondrial outer membrane; mitochondrion; nucleus; response to cold; response to drug; response to ethanol IPR018485; IPR018483; IPR018484; IPR005999; Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. Glycerol kinase (GK) (Glycerokinase) (EC 2.7.1.30) (ATP-stimulated glucocorticoid-receptor translocation promoter) (ASTP) (ATP:glycerol 3-phosphotransferase) Gk Gyk Rattus norvegicus (Rat) TR37071_c2_g1_i3 Q04164 SAS_DROME 4.00E-10 GO:0016324; GO:0002168; GO:0005887; GO:0004872 apical plasma membrane; instar larval development; integral to plasma membrane; receptor activity IPR003961; IPR013783; IPR001007; Putative epidermal cell surface receptor (Stranded at second protein) sas CG2507 Drosophila melanogaster (Fruit fly) TR37071_c2_g1_i8 Q04164 SAS_DROME 4.00E-10 GO:0016324; GO:0002168; GO:0005887; GO:0004872 apical plasma membrane; instar larval development; integral to plasma membrane; receptor activity IPR003961; IPR013783; IPR001007; Putative epidermal cell surface receptor (Stranded at second protein) sas CG2507 Drosophila melanogaster (Fruit fly) TR37071_c2_g1_i9 Q04164 SAS_DROME 4.00E-10 GO:0016324; GO:0002168; GO:0005887; GO:0004872 apical plasma membrane; instar larval development; integral to plasma membrane; receptor activity IPR003961; IPR013783; IPR001007; Putative epidermal cell surface receptor (Stranded at second protein) sas CG2507 Drosophila melanogaster (Fruit fly) TR37072_c0_g1_i2 Q9Z186 G6PC2_MOUSE 5.00E-76 GO:0005789; GO:0006094; GO:0042593; GO:0016787; GO:0016021; GO:0050796 endoplasmic reticulum membrane; gluconeogenesis; glucose homeostasis; hydrolase activity; integral to membrane; regulation of insulin secretion IPR016275; IPR000326; Carbohydrate biosynthesis; gluconeogenesis. Glucose-6-phosphatase 2 (G-6-Pase 2) (G6Pase 2) (EC 3.1.3.9) (Islet-specific glucose-6-phosphatase catalytic subunit-related protein) G6pc2 Igrp Mus musculus (Mouse) TR37072_c0_g1_i4 Q9NQR9 G6PC2_HUMAN 4.00E-72 GO:0005975; GO:0005789; GO:0006094; GO:0042593; GO:0015758; GO:0004346; GO:0016021; GO:0050796; GO:0044281; GO:0055085 carbohydrate metabolic process; endoplasmic reticulum membrane; gluconeogenesis; glucose homeostasis; glucose transport; glucose-6-phosphatase activity; integral to membrane; regulation of insulin secretion; small molecule metabolic process; transmembrane transport IPR016275; IPR000326; Carbohydrate biosynthesis; gluconeogenesis. Glucose-6-phosphatase 2 (G-6-Pase 2) (G6Pase 2) (EC 3.1.3.9) (Islet-specific glucose-6-phosphatase catalytic subunit-related protein) G6PC2 IGRP Homo sapiens (Human) TR37073_c1_g1_i1 Q8MQI6 ELOF1_DROME 2.00E-32 GO:0046872; GO:0005634; GO:0006355; GO:0006351 Q9VFY4 "metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007808; Transcription elongation factor 1 homolog CG40228 Drosophila melanogaster (Fruit fly) TR37073_c2_g2_i1 Q9QZD4 XPF_MOUSE 7.00E-173 GO:0001094; GO:0009650; GO:0003684; GO:0000724; GO:0000710; GO:0032205; GO:0000784; GO:0000110; GO:0006295; GO:0006296; GO:0000712; GO:0003697; GO:0000014; GO:0010834; GO:0005669 "TFIID-class transcription factor binding; UV protection; damaged DNA binding; double-strand break repair via homologous recombination; meiotic mismatch repair; negative regulation of telomere maintenance; nuclear chromosome, telomeric region; nucleotide-excision repair factor 1 complex; nucleotide-excision repair, DNA incision, 3'-to lesion; nucleotide-excision repair, DNA incision, 5'-to lesion; resolution of meiotic recombination intermediates; single-stranded DNA binding; single-stranded DNA endodeoxyribonuclease activity; telomere maintenance via telomere shortening; transcription factor TFIID complex" IPR020819; IPR006166; IPR006167; IPR011335; IPR010994; DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) Ercc4 Mus musculus (Mouse) TR37073_c2_g4_i1 Q92889 XPF_HUMAN 3.00E-40 GO:0009650; GO:0003684; GO:0000724; GO:0000710; GO:0032205; GO:0000784; GO:0005654; GO:0000110; GO:0000718; GO:0006295; GO:0006296; GO:0000712; GO:0009411; GO:0003697; GO:0000014; GO:0010834; GO:0005669; GO:0006283 Q8IY92 "UV protection; damaged DNA binding; double-strand break repair via homologous recombination; meiotic mismatch repair; negative regulation of telomere maintenance; nuclear chromosome, telomeric region; nucleoplasm; nucleotide-excision repair factor 1 complex; nucleotide-excision repair, DNA damage removal; nucleotide-excision repair, DNA incision, 3'-to lesion; nucleotide-excision repair, DNA incision, 5'-to lesion; resolution of meiotic recombination intermediates; response to UV; single-stranded DNA binding; single-stranded DNA endodeoxyribonuclease activity; telomere maintenance via telomere shortening; transcription factor TFIID complex; transcription-coupled nucleotide-excision repair" IPR020819; IPR006166; IPR006167; IPR011335; IPR010994; DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) ERCC4 ERCC11 XPF Homo sapiens (Human) TR37076_c0_g2_i1 P49908 SEPP1_HUMAN 4.00E-25 GO:0007420; GO:0005576; GO:0005615; GO:0040007; GO:0007626; GO:0009791; GO:0006979; GO:0008430; GO:0001887; GO:0019953 brain development; extracellular region; extracellular space; growth; locomotory behavior; post-embryonic development; response to oxidative stress; selenium binding; selenium compound metabolic process; sexual reproduction IPR007671; IPR007672; Selenoprotein P (SeP) SEPP1 SELP Homo sapiens (Human) TR37077_c0_g1_i1 Q2KJ44 PTPA_BOVIN 5.00E-126 GO:0005524; GO:0005737; GO:0030472; GO:0005634; GO:0003755; GO:0006457; GO:0000159; GO:0008601; GO:0008160 ATP binding; cytoplasm; mitotic spindle organization in nucleus; nucleus; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein phosphatase type 2A complex; protein phosphatase type 2A regulator activity; protein tyrosine phosphatase activator activity IPR004327; "Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B')" PPP2R4 Bos taurus (Bovine) TR37077_c0_g1_i2 Q55CJ3 PTPA1_DICDI 7.00E-95 GO:0005737; GO:0030472; GO:0005634; GO:0003755; GO:0006457; GO:0000159; GO:0008601; GO:0008160 cytoplasm; mitotic spindle organization in nucleus; nucleus; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein phosphatase type 2A complex; protein phosphatase type 2A regulator activity; protein tyrosine phosphatase activator activity IPR004327; Probable serine/threonine-protein phosphatase 2A activator 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase PTPA-1) (PPIase PTPA-1) (Rotamase PTPA-1) (Phosphotyrosyl phosphatase activator 1) ppp2r4A ppp2r4 DDB_G0270036 Dictyostelium discoideum (Slime mold) TR37077_c0_g1_i3 P58389 PTPA_MOUSE 2.00E-37 GO:0005524; GO:0006200; GO:0005737; GO:0030472; GO:0032515; GO:0035308; GO:0005634; GO:0003755; GO:0032516; GO:0035307; GO:0006457; GO:0042803; GO:0051721; GO:0000159; GO:0008601; GO:0008160 ATP binding; ATP catabolic process; cytoplasm; mitotic spindle organization in nucleus; negative regulation of phosphoprotein phosphatase activity; negative regulation of protein dephosphorylation; nucleus; peptidyl-prolyl cis-trans isomerase activity; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein dephosphorylation; protein folding; protein homodimerization activity; protein phosphatase 2A binding; protein phosphatase type 2A complex; protein phosphatase type 2A regulator activity; protein tyrosine phosphatase activator activity IPR004327; "Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B')" Ppp2r4 Ptpa Mus musculus (Mouse) TR37078_c4_g1_i1 O02695 PTPR2_MACNE 4.00E-132 GO:0016021; GO:0035335; GO:0004725; GO:0030658 integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; transport vesicle membrane IPR021613; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.48) (M1851) PTPRN2 Macaca nemestrina (Pig-tailed macaque) TR37080_c6_g1_i5 O89110 CASP8_MOUSE 3.00E-40 GO:0030690; GO:0006919; GO:0001525; GO:0071260; GO:0005813; GO:0097153; GO:0031264; GO:0008625; GO:0007507; GO:0097284; GO:0030225; GO:0005739; GO:0043124; GO:0060546; GO:0001841; GO:0043123; GO:2001238; GO:0045651; GO:0045862; GO:0051603; GO:0070243; GO:0034612 P10275; P19091; P25446; Q9D8Y7 Noc1p-Noc2p complex; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; death-inducing signaling complex; extrinsic apoptotic signaling pathway via death domain receptors; heart development; hepatocyte apoptotic process; macrophage differentiation; mitochondrion; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of necroptosis; neural tube formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of macrophage differentiation; positive regulation of proteolysis; proteolysis involved in cellular protein catabolic process; regulation of thymocyte apoptotic process; response to tumor necrosis factor IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] Casp8 Mus musculus (Mouse) TR37081_c0_g2_i1 Q8R4I7 NETO1_MOUSE 2.00E-37 GO:0030054; GO:0060076; GO:0016021; GO:0007613; GO:0014069; GO:0045211; GO:0048169; GO:0008542 cell junction; excitatory synapse; integral to membrane; memory; postsynaptic density; postsynaptic membrane; regulation of long-term neuronal synaptic plasticity; visual learning IPR000859; IPR023415; IPR002172; Neuropilin and tolloid-like protein 1 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1) Neto1 Btcl1 Mus musculus (Mouse) TR37083_c3_g3_i1 Q14515 SPRL1_HUMAN 7.00E-07 GO:0005509; GO:0005615; GO:0005578; GO:0007165 calcium ion binding; extracellular space; proteinaceous extracellular matrix; signal transduction IPR011992; IPR018247; IPR002048; IPR003645; IPR015369; IPR002350; IPR001999; IPR016359; IPR019577; SPARC-like protein 1 (High endothelial venule protein) (Hevin) (MAST 9) SPARCL1 Homo sapiens (Human) TR37084_c1_g3_i4 O75486 SUPT3_HUMAN 3.00E-63 GO:0006352; GO:0030914; GO:0043966; GO:0016578; GO:0045893; GO:0006357; GO:0003713; GO:0033276; GO:0006366 "DNA-dependent transcription, initiation; STAGA complex; histone H3 acetylation; histone deubiquitination; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcription factor TFTC complex; transcription from RNA polymerase II promoter" IPR009072; IPR003195; Transcription initiation protein SPT3 homolog (SPT3-like protein) SUPT3H SPT3 Homo sapiens (Human) TR37085_c0_g2_i2 Q5DX34 RPGRH_CAEEL 5.00E-45 GO:0030424; GO:0005085; GO:0045202 axon; guanyl-nucleotide exchange factor activity; synapse IPR009091; IPR000408; X-linked retinitis pigmentosa GTPase regulator homolog (Gut granule loss protein 4) glo-4 F07C3.4 Caenorhabditis elegans TR37086_c0_g1_i1 Q8BFR6 ZFAN1_MOUSE 5.00E-51 GO:0008270 zinc ion binding IPR000058; AN1-type zinc finger protein 1 Zfand1 Mus musculus (Mouse) TR37086_c0_g1_i3 Q8TCF1 ZFAN1_HUMAN 8.00E-52 GO:0008270 zinc ion binding IPR000058; AN1-type zinc finger protein 1 ZFAND1 Homo sapiens (Human) TR37086_c1_g2_i1 Q8YA32 INLI_LISMO 3.00E-09 GO:0005618; GO:0005576 cell wall; extracellular region IPR025556; IPR014755; IPR014756; IPR001611; IPR025875; IPR019931; IPR012569; IPR000601; Internalin-I inlI lmo0333 Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) TR37086_c1_g2_i6 Q28CU0 LRC23_XENTR 2.00E-96 IPR001611; IPR025875; Leucine-rich repeat-containing protein 23 lrrc23 TNeu057d16.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37087_c0_g1_i1 Q7S565 COQ1_NEUCR 9.00E-32 GO:0008299; GO:0046872; GO:0005739; GO:0000010; GO:0006744 isoprenoid biosynthetic process; metal ion binding; mitochondrion; trans-hexaprenyltranstransferase activity; ubiquinone biosynthetic process IPR000092; IPR017446; IPR008949; Cofactor biosynthesis; ubiquinone biosynthesis. "Probable hexaprenyl pyrophosphate synthase, mitochondrial (HPS) (EC 2.5.1.-)" NCU02305 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR37087_c0_g1_i2 Q86YH6 DLP1_HUMAN 7.00E-82 GO:0008299; GO:0005759; GO:0046982; GO:0051290; GO:0050878; GO:0000010; GO:0050347; GO:0006744 isoprenoid biosynthetic process; mitochondrial matrix; protein heterodimerization activity; protein heterotetramerization; regulation of body fluid levels; trans-hexaprenyltranstransferase activity; trans-octaprenyltranstransferase activity; ubiquinone biosynthetic process IPR000092; IPR017446; IPR008949; Cofactor biosynthesis; ubiquinone biosynthesis. Decaprenyl-diphosphate synthase subunit 2 (EC 2.5.1.91) (All-trans-decaprenyl-diphosphate synthase subunit 2) (Candidate tumor suppressor protein) (Decaprenyl pyrophosphate synthase subunit 2) PDSS2 C6orf210 DLP1 Homo sapiens (Human) TR37088_c2_g1_i1 Q9H0E2 TOLIP_HUMAN 3.00E-74 GO:0007267; GO:0005829; GO:0006954; GO:0045087; GO:0045323; GO:0045092; GO:0035556; GO:0045321; GO:0016604; GO:0048471; GO:0016310; GO:0033235; GO:0004871 Q05048; Q15038; Q86Y13; P19525; O43187; Q86TG7; O75674; Q96S55 cell-cell signaling; cytosol; inflammatory response; innate immune response; interleukin-1 receptor complex; interleukin-18 receptor complex; intracellular signal transduction; leukocyte activation; nuclear body; perinuclear region of cytoplasm; phosphorylation; positive regulation of protein sumoylation; signal transducer activity IPR000008; IPR003892; IPR009060; Toll-interacting protein TOLLIP Homo sapiens (Human) TR37089_c0_g1_i2 Q9VSH3 BI1_DROME 7.00E-33 GO:0006915; GO:0009267; GO:0005789; GO:0016021; GO:0043066; GO:0010507; GO:0060548; GO:0060702; GO:0006986; GO:0035071 apoptotic process; cellular response to starvation; endoplasmic reticulum membrane; integral to membrane; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of cell death; negative regulation of endoribonuclease activity; response to unfolded protein; salivary gland cell autophagic cell death IPR006213; IPR006214; Probable Bax inhibitor 1 (BI-1) CG7188 Drosophila melanogaster (Fruit fly) TR37089_c0_g1_i4 Q9IA79 BI1_PAROL 1.00E-75 GO:0006915; GO:0005789; GO:0016021; GO:0043066; GO:0006986 apoptotic process; endoplasmic reticulum membrane; integral to membrane; negative regulation of apoptotic process; response to unfolded protein IPR006213; IPR006214; Probable Bax inhibitor 1 (BI-1) (Testis-enhanced gene transcript protein homolog) (Transmembrane BAX inhibitor motif-containing protein 6) tmbim6 tegt Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus) TR3709_c0_g1_i1 Q9NGQ2 KIF1_DICDI 4.00E-55 GO:0005524; GO:0030659; GO:0005871; GO:0005874; GO:0003777; GO:0007018; GO:0005543; GO:0006810 ATP binding; cytoplasmic vesicle membrane; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement; phospholipid binding; transport IPR000253; IPR022140; IPR027640; IPR019821; IPR001752; IPR027417; IPR011993; IPR001849; IPR008984; Kinesin-related protein 1 (Kinesin family member 1) (Kinesin-3) kif1 kif1A unc104 DDB_G0290963 Dictyostelium discoideum (Slime mold) TR37093_c0_g1_i1 Q9QUR6 PPCE_MOUSE 0 GO:0005737; GO:0005634; GO:0019538; GO:0006508; GO:0004252; GO:0070008 cytoplasm; nucleus; protein metabolic process; proteolysis; serine-type endopeptidase activity; serine-type exopeptidase activity IPR002471; IPR023302; IPR001375; IPR002470; Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) Prep Pep Mus musculus (Mouse) TR37093_c0_g1_i2 P55577 Y4NA_RHISN 6.00E-61 GO:0006508; GO:0004252; GO:0070008 proteolysis; serine-type endopeptidase activity; serine-type exopeptidase activity IPR023302; IPR001375; IPR002470; Uncharacterized peptidase y4nA (EC 3.4.21.-) NGR_a02410 y4nA Rhizobium sp. (strain NGR234) TR37094_c0_g1_i3 Q23551 UNC22_CAEEL 1.00E-13 GO:0031672; GO:0005524; GO:0046872; GO:0004674 A band; ATP binding; metal ion binding; protein serine/threonine kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans TR37094_c0_g1_i5 Q9I7U4 TITIN_DROME 3.00E-65 GO:0030018; GO:0003779; GO:0051301; GO:0000794; GO:0040011; GO:0007498; GO:0005875; GO:0007076; GO:0016203; GO:0007520; GO:0035206; GO:0045214; GO:0007062; GO:0007519; GO:0007525; GO:0008307; GO:0007522 Z disc; actin binding; cell division; condensed nuclear chromosome; locomotion; mesoderm development; microtubule associated complex; mitotic chromosome condensation; muscle attachment; myoblast fusion; regulation of hemocyte proliferation; sarcomere organization; sister chromatid cohesion; skeletal muscle tissue development; somatic muscle development; structural constituent of muscle; visceral muscle development IPR010939; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR001452; Titin (D-Titin) (Kettin) sls titin CG1915 Drosophila melanogaster (Fruit fly) TR37096_c5_g1_i2 Q5RAY0 PFD5_PONAB 2.00E-44 GO:0005634; GO:0016272; GO:0006457 nucleus; prefoldin complex; protein folding IPR011599; IPR027236; IPR009053; IPR004127; Prefoldin subunit 5 PFDN5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37097_c0_g1_i4 Q5ZML3 SRSF1_CHICK 4.00E-40 GO:0003723; GO:0008380; GO:0006397; GO:0000166; GO:0005634 RNA binding; RNA splicing; mRNA processing; nucleotide binding; nucleus IPR012677; IPR000504; "Serine/arginine-rich splicing factor 1 (Splicing factor, arginine/serine-rich 1)" SRSF1 SFRS1 RCJMB04_1l5 Gallus gallus (Chicken) TR37097_c0_g1_i6 Q13247 SRSF6_HUMAN 5.00E-12 GO:0003723; GO:0031124; GO:0006406; GO:0006376; GO:0048025; GO:0005654; GO:0000166; GO:0006369 "RNA binding; mRNA 3'-end processing; mRNA export from nucleus; mRNA splice site selection; negative regulation of mRNA splicing, via spliceosome; nucleoplasm; nucleotide binding; termination of RNA polymerase II transcription" IPR012677; IPR000504; "Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)" SRSF6 SFRS6 SRP55 Homo sapiens (Human) TR37097_c0_g1_i9 Q5ZML3 SRSF1_CHICK 6.00E-44 GO:0003723; GO:0008380; GO:0006397; GO:0000166; GO:0005634 RNA binding; RNA splicing; mRNA processing; nucleotide binding; nucleus IPR012677; IPR000504; "Serine/arginine-rich splicing factor 1 (Splicing factor, arginine/serine-rich 1)" SRSF1 SFRS1 RCJMB04_1l5 Gallus gallus (Chicken) TR37098_c2_g1_i5 Q3BAI2 YCX91_PHAAO 7.00E-09 GO:0009507 chloroplast Uncharacterized protein ORF91 Phalaenopsis aphrodite subsp. formosana (Moth orchid) TR37098_c2_g1_i8 Q3BAI2 YCX91_PHAAO 1.00E-08 GO:0009507 chloroplast Uncharacterized protein ORF91 Phalaenopsis aphrodite subsp. formosana (Moth orchid) TR37099_c0_g1_i1 Q28C74 LPPRC_XENTR 4.00E-44 GO:0003677; GO:0003723; GO:0005739; GO:0005634; GO:0006355; GO:0006351; GO:0006810 "DNA binding; RNA binding; mitochondrion; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; transport" IPR016024; IPR002885; IPR011990; "Leucine-rich PPR motif-containing protein, mitochondrial" lrpprc TTpA007l07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37099_c0_g1_i2 Q9FJE6 PP437_ARATH 2.00E-14 IPR002885; IPR011990; Putative pentatricopeptide repeat-containing protein At5g59900 At5g59900 MMN10.14 Arabidopsis thaliana (Mouse-ear cress) TR37100_c2_g1_i2 Q566Y1 ELP4_DANRE 3.00E-10 GO:0033588; GO:0005737; GO:0008607; GO:0006357; GO:0008023; GO:0006351 "Elongator holoenzyme complex; cytoplasm; phosphorylase kinase regulator activity; regulation of transcription from RNA polymerase II promoter; transcription elongation factor complex; transcription, DNA-dependent" IPR008728; Elongator complex protein 4 (ELP4) elp4 si:dkey-157g7.1 zgc:112389 Danio rerio (Zebrafish) (Brachydanio rerio) TR37100_c2_g2_i1 Q54XS0 ELP4_DICDI 3.00E-29 GO:0033588; GO:0005737; GO:0008607; GO:0006357; GO:0008023; GO:0006351 "Elongator holoenzyme complex; cytoplasm; phosphorylase kinase regulator activity; regulation of transcription from RNA polymerase II promoter; transcription elongation factor complex; transcription, DNA-dependent" IPR008728; Probable elongator complex protein 4 (ELP4) elp4 DDB_G0278783 Dictyostelium discoideum (Slime mold) TR37100_c2_g2_i2 Q566Y1 ELP4_DANRE 2.00E-88 GO:0033588; GO:0005737; GO:0008607; GO:0006357; GO:0008023; GO:0006351 "Elongator holoenzyme complex; cytoplasm; phosphorylase kinase regulator activity; regulation of transcription from RNA polymerase II promoter; transcription elongation factor complex; transcription, DNA-dependent" IPR008728; Elongator complex protein 4 (ELP4) elp4 si:dkey-157g7.1 zgc:112389 Danio rerio (Zebrafish) (Brachydanio rerio) TR37100_c2_g2_i4 Q18195 ELP4_CAEEL 6.00E-15 GO:0033588; GO:0005737; GO:0008607; GO:0006357; GO:0008023; GO:0006351 "Elongator holoenzyme complex; cytoplasm; phosphorylase kinase regulator activity; regulation of transcription from RNA polymerase II promoter; transcription elongation factor complex; transcription, DNA-dependent" IPR008728; Putative elongator complex protein 4 (ELP4) elpc-4 C26B2.6 Caenorhabditis elegans TR37101_c2_g1_i1 Q5ZLT0 XPO7_CHICK 0 GO:0005737; GO:0006886; GO:0005634 cytoplasm; intracellular protein transport; nucleus IPR016024; IPR001494; Exportin-7 XPO7 RCJMB04_4p4 Gallus gallus (Chicken) TR37101_c2_g3_i2 Q5ZLT0 XPO7_CHICK 0 GO:0005737; GO:0006886; GO:0005634 cytoplasm; intracellular protein transport; nucleus IPR016024; IPR001494; Exportin-7 XPO7 RCJMB04_4p4 Gallus gallus (Chicken) TR37102_c3_g1_i1 Q5TKR9 KAT6A_RAT 9.00E-26 GO:0003677; GO:0070776; GO:0016605; GO:0090398; GO:0043966; GO:0004402; GO:0030099; GO:0045892; GO:0005730; GO:0000786; GO:0006334; GO:0045893; GO:0008134; GO:0006351; GO:0008270 "DNA binding; MOZ/MORF histone acetyltransferase complex; PML body; cellular senescence; histone H3 acetylation; histone acetyltransferase activity; myeloid cell differentiation; negative regulation of transcription, DNA-dependent; nucleolus; nucleosome; nucleosome assembly; positive regulation of transcription, DNA-dependent; transcription factor binding; transcription, DNA-dependent; zinc ion binding" IPR016181; IPR005818; IPR002717; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; "Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger homolog) (Monocytic leukemia zinc finger protein)" Kat6a Moz Myst3 Rattus norvegicus (Rat) TR37102_c3_g1_i2 P58267 DPF1_CHICK 9.00E-27 GO:0005737; GO:0007399; GO:0003676; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "cytoplasm; nervous system development; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR025750; IPR007087; IPR015880; IPR013087; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; "Zinc finger protein neuro-d4 (D4, zinc and double PHD fingers family 1)" DPF1 NEUD4 Gallus gallus (Chicken) TR37102_c3_g1_i3 Q91YE5 BAZ2A_MOUSE 4.00E-09 GO:0003677; GO:0006306; GO:0003723; GO:0000183; GO:0005677; GO:0070869; GO:0051567; GO:0070933; GO:0034770; GO:0070577; GO:0005730; GO:0033553; GO:0006351; GO:0008270 "DNA binding; DNA methylation; RNA binding; chromatin silencing at rDNA; chromatin silencing complex; heterochromatin assembly involved in chromatin silencing; histone H3-K9 methylation; histone H4 deacetylation; histone H4-K20 methylation; histone acetyl-lysine binding; nucleolus; rDNA heterochromatin; transcription, DNA-dependent; zinc ion binding" IPR017956; IPR001487; IPR018359; IPR004022; IPR018500; IPR018501; IPR016177; IPR001739; IPR011011; IPR001965; IPR019787; IPR013083; Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) Baz2a Kiaa0314 Tip5 Mus musculus (Mouse) TR37102_c3_g1_i4 Q61103 REQU_MOUSE 2.00E-24 GO:0006915; GO:0005813; GO:0005737; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "apoptotic process; centrosome; cytoplasm; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR025750; IPR007087; IPR015880; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; "Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem)" Dpf2 Baf45d Req Ubid4 Mus musculus (Mouse) TR37102_c3_g1_i5 Q5VXD3 SAM13_HUMAN 3.00E-23 IPR001660; IPR013761; IPR021129; Sterile alpha motif domain-containing protein 13 (SAM domain-containing protein 13) SAMD13 HSD-42 HSD42 Homo sapiens (Human) TR37102_c3_g1_i6 P58267 DPF1_CHICK 2.00E-26 GO:0005737; GO:0007399; GO:0003676; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "cytoplasm; nervous system development; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR025750; IPR007087; IPR015880; IPR013087; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; "Zinc finger protein neuro-d4 (D4, zinc and double PHD fingers family 1)" DPF1 NEUD4 Gallus gallus (Chicken) TR37103_c0_g1_i3 O76463 NFT1_CAEEL 7.00E-144 GO:0047710; GO:0016810; GO:0006139; GO:0000166 "bis(5'-adenosyl)-triphosphatase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; nucleobase-containing compound metabolic process; nucleotide binding" IPR003010; IPR019808; IPR001310; IPR011146; IPR001110; "Nitrilase and fragile histidine triad fusion protein NitFhit [Includes: Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Diadenosine 5',5'''-P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase); Nitrilase homolog (EC 3.5.-.-)]" nft-1 Y56A3A.13 Caenorhabditis elegans TR37103_c0_g1_i4 Q86X76 NIT1_HUMAN 8.00E-59 GO:0005739; GO:0000257; GO:0006807 mitochondrion; nitrilase activity; nitrogen compound metabolic process IPR003010; IPR001110; Nitrilase homolog 1 (EC 3.5.-.-) NIT1 Homo sapiens (Human) TR37105_c1_g1_i1 Q2KID9 RT05_BOVIN 4.00E-49 GO:0003723; GO:0005739; GO:0005840; GO:0003735; GO:0006412 RNA binding; mitochondrion; ribosome; structural constituent of ribosome; translation IPR014720; IPR000851; IPR005324; IPR020568; IPR014721; IPR013810; IPR018192; "28S ribosomal protein S5, mitochondrial (MRP-S5) (S5mt)" MRPS5 Bos taurus (Bovine) TR37106_c0_g2_i1 Q9BXF9 TEKT3_HUMAN 4.00E-171 GO:0035085; GO:0005874; GO:0000226 cilium axoneme; microtubule; microtubule cytoskeleton organization IPR000435; Tektin-3 TEKT3 Homo sapiens (Human) TR37108_c4_g2_i1 P13608 PGCA_BOVIN 1.00E-07 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 Q9UNA0; P49747 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Bos taurus (Bovine) TR37108_c4_g2_i3 P86854 PLCL_MYTGA 4.00E-11 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR37108_c4_g2_i4 P86854 PLCL_MYTGA 4.00E-10 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR37108_c4_g2_i6 P13608 PGCA_BOVIN 1.00E-07 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 Q9UNA0; P49747 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Bos taurus (Bovine) TR37111_c1_g1_i1 Q2JLX1 COAE_SYNJB 3.00E-26 GO:0005524; GO:0015937; GO:0005737; GO:0004140 ATP binding; coenzyme A biosynthetic process; cytoplasm; dephospho-CoA kinase activity IPR001977; IPR027417; Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase) coaE CYB_1306 Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) TR37111_c1_g1_i2 Q0P4C4 DCAKD_DANRE 3.00E-67 GO:0005524; GO:0015937; GO:0004140 ATP binding; coenzyme A biosynthetic process; dephospho-CoA kinase activity IPR001977; IPR027417; Dephospho-CoA kinase domain-containing protein dcakd zgc:153150 Danio rerio (Zebrafish) (Brachydanio rerio) TR37111_c2_g1_i1 Q16IW3 RU1C_AEDAE 3.00E-38 GO:0030619; GO:0005685; GO:0071004; GO:0000243; GO:0000395; GO:0003729; GO:0000387; GO:0008270 U1 snRNA binding; U1 snRNP; U2-type prespliceosome; commitment complex; mRNA 5'-splice site recognition; mRNA binding; spliceosomal snRNP assembly; zinc ion binding IPR017340; IPR000690; IPR003604; IPR013085; U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) AAEL013527 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR37112_c3_g1_i1 Q8BIK4 DOCK9_MOUSE 4.00E-62 GO:0005089; GO:0012505; GO:0016020; GO:0005543; GO:0007264 Rho guanyl-nucleotide exchange factor activity; endomembrane system; membrane; phospholipid binding; small GTPase mediated signal transduction IPR016024; IPR027007; IPR027357; IPR026791; IPR010703; IPR021816; IPR026796; IPR011993; IPR001849; Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) Dock9 D14Wsu89e Kiaa1058 Mus musculus (Mouse) TR37112_c3_g1_i2 Q63603 DOCK9_RAT 6.00E-63 GO:0012505; GO:0005085; GO:0016020; GO:0007264 endomembrane system; guanyl-nucleotide exchange factor activity; membrane; small GTPase mediated signal transduction IPR027357; IPR026791; IPR010703; IPR026796; Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Protein TRG) (Fragment) Dock9 Trg Rattus norvegicus (Rat) TR37112_c6_g1_i1 Q8BIK4 DOCK9_MOUSE 1.00E-25 GO:0005089; GO:0012505; GO:0016020; GO:0005543; GO:0007264 Rho guanyl-nucleotide exchange factor activity; endomembrane system; membrane; phospholipid binding; small GTPase mediated signal transduction IPR016024; IPR027007; IPR027357; IPR026791; IPR010703; IPR021816; IPR026796; IPR011993; IPR001849; Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) Dock9 D14Wsu89e Kiaa1058 Mus musculus (Mouse) TR37113_c0_g1_i3 Q54CI5 DPH4_DICDI 5.00E-20 GO:0005737; GO:0046872; GO:0017183 cytoplasm; metal ion binding; peptidyl-diphthamide biosynthetic process from peptidyl-histidine IPR001623; IPR018253; IPR007872; DPH4 homolog (DnaJ homolog subfamily C member 24) dph4 dnajc24 DDB_G0292980 Dictyostelium discoideum (Slime mold) TR37113_c0_g1_i5 Q0VBY7 DJC24_BOVIN 7.00E-18 GO:0001671; GO:0005737; GO:0005856; GO:0008198; GO:0055114; GO:0017183; GO:0008270 ATPase activator activity; cytoplasm; cytoskeleton; ferrous iron binding; oxidation-reduction process; peptidyl-diphthamide biosynthetic process from peptidyl-histidine; zinc ion binding IPR001623; IPR007872; Protein modification; peptidyl-diphthamide biosynthesis. DnaJ homolog subfamily C member 24 (CSL-type zinc finger-containing protein 3) (Diphthamide biosynthesis protein 4) DNAJC24 DPH4 ZCSL3 Bos taurus (Bovine) TR37113_c0_g1_i6 Q9QYI4 DJB12_MOUSE 1.00E-07 GO:0016021 integral to membrane IPR001623; IPR018253; IPR015399; DnaJ homolog subfamily B member 12 (mDj10) Dnajb12 Mus musculus (Mouse) TR37115_c0_g1_i2 Q6AY22 SPAT1_RAT 5.00E-21 Spermatogenesis-associated protein 1 Spata1 Rattus norvegicus (Rat) TR37115_c0_g1_i8 Q5VX52 SPAT1_HUMAN 2.00E-19 Spermatogenesis-associated protein 1 (Sperm-specific protein SP-2) SPATA1 Homo sapiens (Human) TR37116_c2_g1_i1 Q4ZJM9 C1QL4_MOUSE 8.00E-09 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) TR37116_c3_g1_i7 P54797 T10_MOUSE 1.00E-43 GO:0005739 mitochondrion IPR008551; Transport and Golgi organization 2 homolog (Ser/Thr-rich protein T10 in DGCR region) Tango2 D16H22S680E T10 Mus musculus (Mouse) TR37117_c0_g1_i1 Q91YU8 SSF1_MOUSE 6.00E-128 GO:0005730; GO:0001560 nucleolus; regulation of cell growth by extracellular stimulus IPR004154; IPR007109; Suppressor of SWI4 1 homolog (Ssf-1) (Peter Pan homolog) Ppan Ssf1 Mus musculus (Mouse) TR37119_c2_g1_i1 P98203 ARVC_MOUSE 3.00E-108 GO:0016339; GO:0005737; GO:0005634; GO:0005886 calcium-dependent cell-cell adhesion; cytoplasm; nucleus; plasma membrane IPR011989; IPR016024; IPR000225; Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog Arvcf Mus musculus (Mouse) TR37121_c3_g1_i1 Q9Y2X3 NOP58_HUMAN 1.00E-159 GO:0015030; GO:0031428; GO:0016049; GO:0005737; GO:0070761; GO:0006364; GO:0006608; GO:0030515 Q96RS0 Cajal body; box C/D snoRNP complex; cell growth; cytoplasm; pre-snoRNP complex; rRNA processing; snRNP protein import into nucleus; snoRNA binding IPR012974; IPR002687; IPR012976; Nucleolar protein 58 (Nucleolar protein 5) NOP58 NOL5 NOP5 HSPC120 Homo sapiens (Human) TR37122_c1_g3_i1 O35218 CPSF2_MOUSE 0 GO:0003723; GO:0006398; GO:0016787; GO:0006379; GO:0005847; GO:0006378 RNA binding; histone mRNA 3'-end processing; hydrolase activity; mRNA cleavage; mRNA cleavage and polyadenylation specificity factor complex; mRNA polyadenylation IPR001279; IPR022712; IPR027075; IPR025069; IPR011108; Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit) Cpsf2 Cpsf100 Mcpsf Mus musculus (Mouse) TR37123_c1_g3_i1 Q6CGE1 PPME1_YARLI 4.00E-28 GO:0004091 carboxylesterase activity IPR016812; Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) PPE1 YALI0A20086g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR37123_c1_g3_i2 Q8BVQ5 PPME1_MOUSE 5.00E-85 GO:0004091; GO:0051722; GO:0006482; GO:0051721 carboxylesterase activity; protein C-terminal methylesterase activity; protein demethylation; protein phosphatase 2A binding IPR000073; IPR000639; IPR016812; Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) Ppme1 Pme1 Mus musculus (Mouse) TR37123_c1_g3_i3 Q4IQC1 PPME1_GIBZE 2.00E-31 GO:0004091 carboxylesterase activity IPR016812; Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) PPE1 FGSG_00587 Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum) TR37123_c1_g3_i6 Q9BIB3 PPME1_CAEEL 1.00E-54 GO:0004091; GO:0051722; GO:0006482; GO:0051721 carboxylesterase activity; protein C-terminal methylesterase activity; protein demethylation; protein phosphatase 2A binding IPR000073; IPR000639; IPR016812; Probable protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) B0464.9 Caenorhabditis elegans TR37123_c1_g3_i7 Q8BVQ5 PPME1_MOUSE 2.00E-85 GO:0004091; GO:0051722; GO:0006482; GO:0051721 carboxylesterase activity; protein C-terminal methylesterase activity; protein demethylation; protein phosphatase 2A binding IPR000073; IPR000639; IPR016812; Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) Ppme1 Pme1 Mus musculus (Mouse) TR37124_c0_g1_i1 P10394 POL4_DROME 4.00E-48 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR37124_c1_g1_i1 Q09575 YRD6_CAEEL 9.00E-47 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR37125_c1_g1_i1 P10280 IP52_ANESU 5.00E-15 GO:0005576; GO:0042151; GO:0004867 extracellular region; nematocyst; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Kunitz-type proteinase inhibitor 5 II (SA5 II) Anemonia sulcata (Mediterranean snakelocks sea anemone) (Anemonia viridis) TR37126_c1_g1_i1 Q7TS68 NSUN6_MOUSE 4.00E-126 GO:0003723; GO:0008168 RNA binding; methyltransferase activity IPR001678; IPR002478; IPR015947; IPR023267; Putative methyltransferase NSUN6 (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 6) Nsun6 Mus musculus (Mouse) TR37126_c1_g1_i4 Q7TS68 NSUN6_MOUSE 2.00E-124 GO:0003723; GO:0008168 RNA binding; methyltransferase activity IPR001678; IPR002478; IPR015947; IPR023267; Putative methyltransferase NSUN6 (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 6) Nsun6 Mus musculus (Mouse) TR37127_c1_g1_i1 Q9H936 GHC1_HUMAN 5.00E-42 GO:0005313; GO:0016021; GO:0005743; GO:0005634; GO:0015293 L-glutamate transmembrane transporter activity; integral to membrane; mitochondrial inner membrane; nucleus; symporter activity IPR002067; IPR018108; IPR023395; Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22) SLC25A22 GC1 Homo sapiens (Human) TR37127_c2_g1_i1 P39953 YEA6_YEAST 5.00E-11 GO:0035352; GO:0051724; GO:0016021; GO:0005743 NAD transmembrane transport; NAD transporter activity; integral to membrane; mitochondrial inner membrane IPR002067; IPR018108; IPR023395; Mitochondrial nicotinamide adenine dinucleotide transporter 2 (Mitochondrial NAD(+) transporter 2) YEA6 NDT2 YEL006W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR37127_c2_g1_i2 Q5XGI1 KMCP1_XENTR 3.00E-10 GO:0016021; GO:0005743; GO:0006839 integral to membrane; mitochondrial inner membrane; mitochondrial transport IPR002030; IPR018108; IPR023395; Kidney mitochondrial carrier protein 1 (Solute carrier family 25 member 30) slc25a30 kmcp1 TGas086a12.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37128_c1_g1_i5 Q9NW38 FANCL_HUMAN 3.00E-87 GO:0006281; GO:0043240; GO:0005737; GO:0007276; GO:0005635; GO:0006513; GO:0042127; GO:0004842; GO:0008270 DNA repair; Fanconi anaemia nuclear complex; cytoplasm; gamete generation; nuclear envelope; protein monoubiquitination; regulation of cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR026848; IPR019162; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase FANCL (EC 6.3.2.-) (Fanconi anemia group L protein) (Fanconi anemia-associated polypeptide of 43 kDa) (FAAP43) FANCL PHF9 Homo sapiens (Human) TR37129_c5_g1_i3 Q7SXS2 YIPF5_XENLA 9.00E-86 GO:0000139; GO:0005789; GO:0016021; GO:0015031; GO:0016192 Golgi membrane; endoplasmic reticulum membrane; integral to membrane; protein transport; vesicle-mediated transport IPR006977; Protein YIPF5 (YIP1 family member 5) yipf5 Xenopus laevis (African clawed frog) TR37129_c6_g1_i1 O94813 SLIT2_HUMAN 1.00E-07 GO:0005095; GO:0035385; GO:0061364; GO:0048846; GO:0048754; GO:0005509; GO:0002042; GO:0009986; GO:0016337; GO:0071504; GO:0032870; GO:0045499; GO:0021836; GO:0021972; GO:0005737; GO:0033563; GO:0005615; GO:0008201; GO:0001701; GO:0050929; GO:0043237; GO:0060763; GO:0001656; GO:0008045; GO:0030837; GO:0030308; GO:0008285; GO:0090288; GO:0070100; GO:0010596; GO:0010629; GO:0010593; GO:0090027; GO:0071676; GO:0090024; GO:0001933; GO:0090260; GO:0051058; GO:0071672; GO:0043116; GO:0005886; GO:0043065; GO:0050772; GO:0042803; GO:0051414; GO:0031290; GO:0001657 Itself GTPase inhibitor activity; Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; branching morphogenesis of an epithelial tube; calcium ion binding; cell migration involved in sprouting angiogenesis; cell surface; cell-cell adhesion; cellular response to heparin; cellular response to hormone stimulus; chemorepellent activity; chemorepulsion involved in postnatal olfactory bulb interneuron migration; corticospinal neuron axon guidance through spinal cord; cytoplasm; dorsal/ventral axon guidance; extracellular space; heparin binding; in utero embryonic development; induction of negative chemotaxis; laminin-1 binding; mammary duct terminal end bud growth; metanephros development; motor neuron axon guidance; negative regulation of actin filament polymerization; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cellular response to growth factor stimulus; negative regulation of chemokine-mediated signaling pathway; negative regulation of endothelial cell migration; negative regulation of gene expression; negative regulation of lamellipodium assembly; negative regulation of monocyte chemotaxis; negative regulation of mononuclear cell migration; negative regulation of neutrophil chemotaxis; negative regulation of protein phosphorylation; negative regulation of retinal ganglion cell axon guidance; negative regulation of small GTPase mediated signal transduction; negative regulation of smooth muscle cell chemotaxis; negative regulation of vascular permeability; plasma membrane; positive regulation of apoptotic process; positive regulation of axonogenesis; protein homodimerization activity; response to cortisol stimulus; retinal ganglion cell axon guidance; ureteric bud development IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product] SLIT2 SLIL3 Homo sapiens (Human) TR37130_c1_g1_i1 Q642H2 CRBL2_DANRE 3.00E-12 GO:0030154; GO:0005634; GO:0045600; GO:0046326; GO:0046889; GO:0045893; GO:0043565; GO:0003700; GO:0006351 "cell differentiation; nucleus; positive regulation of fat cell differentiation; positive regulation of glucose import; positive regulation of lipid biosynthetic process; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; cAMP-responsive element-binding protein-like 2 crebl2 zgc:92620 Danio rerio (Zebrafish) (Brachydanio rerio) TR37130_c1_g1_i3 Q642H2 CRBL2_DANRE 2.00E-12 GO:0030154; GO:0005634; GO:0045600; GO:0046326; GO:0046889; GO:0045893; GO:0043565; GO:0003700; GO:0006351 "cell differentiation; nucleus; positive regulation of fat cell differentiation; positive regulation of glucose import; positive regulation of lipid biosynthetic process; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; cAMP-responsive element-binding protein-like 2 crebl2 zgc:92620 Danio rerio (Zebrafish) (Brachydanio rerio) TR37131_c0_g2_i1 Q8JI38 CRVP_PSSEM 8.00E-43 GO:0005576 extracellular region IPR001283; IPR018244; IPR014044; IPR013871; IPR003582; Cysteine-rich venom protein latisemin (CRVP) Pseudolaticauda semifasciata (Black-banded sea krait) (Laticauda semifasciata) TR37135_c2_g1_i1 Q6PCT2 FXL19_HUMAN 7.00E-25 GO:0003677; GO:0008270 DNA binding; zinc ion binding IPR001810; IPR019786; IPR002857; IPR011011; IPR001965; IPR019787; IPR013083; F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19) FBXL19 FBL19 Homo sapiens (Human) TR37135_c2_g1_i4 Q6PB97 FXL19_MOUSE 1.00E-24 GO:0003677; GO:0008270 DNA binding; zinc ion binding IPR001810; IPR019786; IPR002857; IPR011011; IPR001965; IPR019787; IPR013083; F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19) Fbxl19 Mus musculus (Mouse) TR37135_c2_g3_i1 Q5U263 KDM2A_XENTR 3.00E-145 GO:0003677; GO:0070544; GO:0051864; GO:0005654; GO:0006355; GO:0006351; GO:0008270 "DNA binding; histone H3-K36 demethylation; histone demethylase activity (H3-K36 specific); nucleoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003347; IPR019786; IPR002857; IPR011011; IPR001965; IPR019787; IPR013083; Lysine-specific demethylase 2A (EC 1.14.11.27) (F-box and leucine-rich repeat protein 11) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) kdm2a fbxl11 jhdm1a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37135_c2_g3_i3 Q9Y2K7 KDM2A_HUMAN 6.00E-148 GO:0070544; GO:0051864; GO:0000790; GO:0005654; GO:0006355; GO:0006351; GO:0045322; GO:0008270 "histone H3-K36 demethylation; histone demethylase activity (H3-K36 specific); nuclear chromatin; nucleoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent; unmethylated CpG binding; zinc ion binding" IPR001810; IPR003347; IPR019786; IPR002857; IPR011011; IPR001965; IPR019787; IPR013083; Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) KDM2A CXXC8 FBL7 FBXL11 JHDM1A KIAA1004 Homo sapiens (Human) TR37135_c2_g3_i4 O75151 PHF2_HUMAN 7.00E-43 GO:0051213; GO:0032454; GO:0005506; GO:0001889; GO:0035064; GO:0061188; GO:0005730; GO:0006351; GO:0008270 "dioxygenase activity; histone demethylase activity (H3-K9 specific); iron ion binding; liver development; methylated histone residue binding; negative regulation of chromatin silencing at rDNA; nucleolus; transcription, DNA-dependent; zinc ion binding" IPR003347; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) PHF2 KIAA0662 Homo sapiens (Human) TR37135_c2_g3_i6 Q640I9 KDM2B_XENLA 6.00E-94 GO:0003677; GO:0070544; GO:0051864; GO:0005730; GO:0019843; GO:0006355; GO:0006351; GO:0008270 "DNA binding; histone H3-K36 demethylation; histone demethylase activity (H3-K36 specific); nucleolus; rRNA binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001810; IPR003347; IPR002857; IPR011011; IPR001965; IPR019787; Lysine-specific demethylase 2B (EC 1.14.11.27) (F-box and leucine-rich repeat protein 10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) ([Histone-H3]-lysine-36 demethylase 1B) kdm2b fbxl10 jhdm1b Xenopus laevis (African clawed frog) TR37138_c5_g1_i1 Q5TZ07 PPAC2_DANRE 9.00E-37 GO:0016787; GO:0016021; GO:0008152 hydrolase activity; integral to membrane; metabolic process IPR000326; Presqualene diphosphate phosphatase (EC 3.1.3.-) (Phosphatidic acid phosphatase type 2 domain-containing protein 2) ppapdc2 si:ch211-191d7.4 si:ch211-246k22.2 zgc:112181 Danio rerio (Zebrafish) (Brachydanio rerio) TR37141_c0_g2_i2 Q92783 STAM1_HUMAN 8.00E-125 GO:0005070; GO:0005829; GO:0031901; GO:0016197; GO:0007173; GO:0006886; GO:0042059 Q13094; O95630; P0CG53; P0CG48 SH3/SH2 adaptor activity; cytosol; early endosome membrane; endosomal transport; epidermal growth factor receptor signaling pathway; intracellular protein transport; negative regulation of epidermal growth factor receptor signaling pathway IPR008942; IPR000108; IPR001452; IPR003903; IPR002014; IPR018205; Signal transducing adapter molecule 1 (STAM-1) STAM STAM1 Homo sapiens (Human) TR37143_c3_g2_i1 Q6NS21 CLP1_XENLA 1.00E-167 GO:0005524; GO:0046404; GO:0051736; GO:0006397; GO:0051733; GO:0035087; GO:0006388; GO:0000214; GO:0030423 "ATP binding; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity; mRNA processing; polydeoxyribonucleotide kinase activity; siRNA loading onto RISC involved in RNA interference; tRNA splicing, via endonucleolytic cleavage and ligation; tRNA-intron endonuclease complex; targeting of mRNA for destruction involved in RNA interference" IPR027417; IPR010655; Polyribonucleotide 5'-hydroxyl-kinase Clp1 (EC 2.7.1.78) (Polyadenylation factor Clp1) (Polynucleotide kinase Clp1) (Pre-mRNA cleavage complex II protein Clp1) clp1 Xenopus laevis (African clawed frog) TR37143_c3_g2_i2 A5DY33 CLP1_LODEL 7.00E-22 GO:0005524; GO:0006397; GO:0005634 ATP binding; mRNA processing; nucleus mRNA cleavage and polyadenylation factor CLP1 CLP1 LELG_02270 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus) TR37143_c3_g2_i3 Q4R7R3 CLP1_MACFA 0 GO:0005524; GO:0046404; GO:0051736; GO:0006397; GO:0051733; GO:0035087; GO:0006388; GO:0000214; GO:0030423 "ATP binding; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity; mRNA processing; polydeoxyribonucleotide kinase activity; siRNA loading onto RISC involved in RNA interference; tRNA splicing, via endonucleolytic cleavage and ligation; tRNA-intron endonuclease complex; targeting of mRNA for destruction involved in RNA interference" IPR027417; IPR010655; Polyribonucleotide 5'-hydroxyl-kinase Clp1 (EC 2.7.1.78) (Polyadenylation factor Clp1) (Polynucleotide kinase Clp1) (Pre-mRNA cleavage complex II protein Clp1) CLP1 QtsA-14570 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR37145_c3_g2_i4 Q9VL63 U430_DROME 6.00E-10 UPF0430 protein CG31712 CG31712 Drosophila melanogaster (Fruit fly) TR37145_c3_g2_i7 Q9VL63 U430_DROME 6.00E-10 UPF0430 protein CG31712 CG31712 Drosophila melanogaster (Fruit fly) TR37146_c1_g2_i1 Q54GE3 VPS45_DICDI 4.00E-166 GO:0000139; GO:0006896; GO:0010008; GO:0045335; GO:0015031; GO:0051082; GO:0006904 Golgi membrane; Golgi to vacuole transport; endosome membrane; phagocytic vesicle; protein transport; unfolded protein binding; vesicle docking involved in exocytosis IPR027482; IPR001619; Vacuolar protein sorting-associated protein 45 vps45 DDB_G0290213 Dictyostelium discoideum (Slime mold) TR37146_c1_g2_i2 Q8WVM8 SCFD1_HUMAN 7.00E-06 GO:0032580; GO:0017119; GO:0005798; GO:0005801; GO:0005789; GO:0005886; GO:0006892; GO:0015031; GO:0060628; GO:0001666; GO:0009636; GO:0006890; GO:0019905; GO:0006904 Q9H9E3 "Golgi cisterna membrane; Golgi transport complex; Golgi-associated vesicle; cis-Golgi network; endoplasmic reticulum membrane; plasma membrane; post-Golgi vesicle-mediated transport; protein transport; regulation of ER to Golgi vesicle-mediated transport; response to hypoxia; response to toxic substance; retrograde vesicle-mediated transport, Golgi to ER; syntaxin binding; vesicle docking involved in exocytosis" IPR027482; IPR001619; Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) SCFD1 C14orf163 KIAA0917 STXBP1L2 FKSG23 Homo sapiens (Human) TR37146_c1_g2_i3 P97390 VPS45_MOUSE 0 GO:0000139; GO:0010008; GO:0016021; GO:0015031; GO:0006904 Golgi membrane; endosome membrane; integral to membrane; protein transport; vesicle docking involved in exocytosis IPR027482; IPR001619; Vacuolar protein sorting-associated protein 45 (mVps45) Vps45 Vps45a Mus musculus (Mouse) TR37147_c1_g2_i1 Q6BRY2 PHO85_DEBHA 1.00E-10 GO:0005524; GO:0004693 ATP binding; cyclin-dependent protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Negative regulator of the PHO system (EC 2.7.11.22) (Serine/threonine-protein kinase PHO85) PHO85 DEHA2D12980g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR37147_c1_g2_i2 Q8QHF0 MOS_ATHNI 2.00E-11 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte maturation factor mos) (Fragment) MOS Atheris nitschei (Great lakes bush viper) TR37147_c1_g3_i2 Q14164 IKKE_HUMAN 8.00E-82 GO:0005524; GO:0008384; GO:0004704; GO:0016605; GO:0035666; GO:0005829; GO:0010008; GO:0045087; GO:0008630; GO:0032480; GO:0043123; GO:0034138; GO:0034142 K7Y1A2; P27958; O00571; Q7Z434; Q92844; Q9UHD2; A7MCY6 ATP binding; IkappaB kinase activity; NF-kappaB-inducing kinase activity; PML body; TRIF-dependent toll-like receptor signaling pathway; cytosol; endosome membrane; innate immune response; intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of type I interferon production; positive regulation of I-kappaB kinase/NF-kappaB cascade; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway IPR011009; IPR000719; IPR017441; Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) IKBKE IKKE IKKI KIAA0151 Homo sapiens (Human) TR37147_c1_g5_i1 Q5BCU8 ATG1_EMENI 4.00E-06 GO:0005524; GO:0000086; GO:0006914; GO:1901892; GO:0034045; GO:0004674; GO:0015031; GO:0000079 ATP binding; G2/M transition of mitotic cell cycle; autophagy; negative regulation of cell septum assembly; pre-autophagosomal structure membrane; protein serine/threonine kinase activity; protein transport; regulation of cyclin-dependent protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR022708; Serine/threonine-protein kinase atg1 (EC 2.7.11.1) (Autophagy-related protein 1) atg1 AN1632 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR37148_c1_g1_i1 P02460 CO2A1_CHICK 2.00E-28 GO:0005604; GO:0001502; GO:0060351; GO:0071773; GO:0007417; GO:0002062; GO:0030199; GO:0005585; GO:0005737; GO:0060272; GO:0001958; GO:0005201; GO:0005615; GO:0003007; GO:0042472; GO:0060174; GO:0046872; GO:0043066; GO:0030903; GO:0071599; GO:0060021; GO:0006029; GO:0010468; GO:0007605; GO:0001894; GO:0007601 basement membrane; cartilage condensation; cartilage development involved in endochondral bone morphogenesis; cellular response to BMP stimulus; central nervous system development; chondrocyte differentiation; collagen fibril organization; collagen type II; cytoplasm; embryonic skeletal joint morphogenesis; endochondral ossification; extracellular matrix structural constituent; extracellular space; heart morphogenesis; inner ear morphogenesis; limb bud formation; metal ion binding; negative regulation of apoptotic process; notochord development; otic vesicle development; palate development; proteoglycan metabolic process; regulation of gene expression; sensory perception of sound; tissue homeostasis; visual perception IPR008160; IPR000885; Collagen alpha-1(II) chain (Alpha-1 type II collagen) (Fragment) COL2A1 Gallus gallus (Chicken) TR37148_c1_g3_i1 P23206 COAA1_BOVIN 7.00E-09 GO:0005581; GO:0005576 collagen; extracellular region IPR001073; IPR008160; IPR008983; Collagen alpha-1(X) chain COL10A1 Bos taurus (Bovine) TR37149_c4_g2_i5 Q0VFN8 CI117_XENTR 3.00E-07 Uncharacterized protein C9orf117 homolog Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37149_c5_g4_i1 Q03278 PO21_NASVI 3.00E-07 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR000477; IPR007087; IPR015880; Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 (Retrovirus-related Pol polyprotein from type I retrotransposable element R2) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] (Fragment) Nasonia vitripennis (Parasitic wasp) TR37149_c5_g4_i2 Q95SX7 RTBS_DROME 7.00E-11 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR37150_c2_g1_i2 Q5T655 CC147_HUMAN 8.00E-140 Coiled-coil domain-containing protein 147 CCDC147 C10orf80 Homo sapiens (Human) TR37153_c3_g1_i1 P48554 RAC2_DROME 9.00E-55 GO:0005525; GO:0003924; GO:0007254; GO:0007266; GO:0051017; GO:0034334; GO:0042742; GO:0007394; GO:0007390; GO:0008258; GO:0035099; GO:0002433; GO:0005622; GO:0030032; GO:0046331; GO:0035011; GO:0007520; GO:0005886; GO:0050770; GO:0007435; GO:0007426 Q24213 "GTP binding; GTPase activity; JNK cascade; Rho protein signal transduction; actin filament bundle assembly; adherens junction maintenance; defense response to bacterium; dorsal closure, elongation of leading edge cells; germ-band shortening; head involution; hemocyte migration; immune response-regulating cell surface receptor signaling pathway involved in phagocytosis; intracellular; lamellipodium assembly; lateral inhibition; melanotic encapsulation of foreign target; myoblast fusion; plasma membrane; regulation of axonogenesis; salivary gland morphogenesis; tracheal outgrowth, open tracheal system" IPR027417; IPR005225; IPR001806; IPR003578; Ras-related protein Rac2 Rac2 RacB CG8556 Drosophila melanogaster (Fruit fly) TR37154_c0_g1_i1 Q64674 SPEE_MOUSE 2.00E-148 GO:0008295; GO:0004766 spermidine biosynthetic process; spermidine synthase activity IPR001045; Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase) Srm Mus musculus (Mouse) TR37154_c0_g1_i2 Q64674 SPEE_MOUSE 3.00E-96 GO:0008295; GO:0004766 spermidine biosynthetic process; spermidine synthase activity IPR001045; Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase) Srm Mus musculus (Mouse) TR37155_c0_g2_i1 Q9D1K7 CT027_MOUSE 2.00E-18 IPR026794; UPF0687 protein C20orf27 homolog Mus musculus (Mouse) TR3716_c1_g1_i1 Q8R3I2 MBOA2_MOUSE 1.00E-19 GO:0047184; GO:0005783; GO:0016021; GO:0008654 1-acylglycerophosphocholine O-acyltransferase activity; endoplasmic reticulum; integral to membrane; phospholipid biosynthetic process IPR004299; Lipid metabolism; phospholipid metabolism. Lysophospholipid acyltransferase 2 (LPLAT 2) (EC 2.3.1.-) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Lysophosphatidylcholine acyltransferase 4) (Lyso-PC acyltransferase 4) (mLPCAT4) (Lysophosphatidylethanolamine acyltransferase) (LPEAT) (Lyso-PE acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 2) (O-acyltransferase domain-containing protein 2) Mboat2 Lpcat4 Oact2 Mus musculus (Mouse) TR37160_c1_g2_i2 O35817 AKA14_RAT 2.00E-30 GO:0005737; GO:0007283 cytoplasm; spermatogenesis IPR025663; A-kinase anchor protein 14 (AKAP-14) (TAKAP-1.2) (Testis-specific A-kinase-anchoring protein TAKAP-80) Akap14 Takap80 Rattus norvegicus (Rat) TR37161_c0_g1_i1 Q9X248 FABG_THEMA 8.00E-46 GO:0004316; GO:0051287; GO:0050661; GO:0030497 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NAD binding; NADP binding; fatty acid elongation IPR011284; IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) (Beta-Ketoacyl-acyl carrier protein reductase) (Beta-ketoacyl-ACP reductase) fabG TM_1724 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR37161_c0_g1_i2 O32185 YUSS_BACSU 5.00E-11 GO:0055114; GO:0016491 oxidation-reduction process; oxidoreductase activity IPR002198; IPR002347; IPR016040; Short-chain dehydrogenase/reductase homolog YusS yusS BSU32910 Bacillus subtilis (strain 168) TR37161_c0_g1_i3 Q01782 PTR1_LEIMA 3.00E-13 GO:0047040; GO:0031427; GO:0006729 pteridine reductase activity; response to methotrexate; tetrahydrobiopterin biosynthetic process IPR002198; IPR002347; IPR016040; IPR014058; IPR020904; Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from biopterin: step 1/1. Pteridine reductase 1 (EC 1.5.1.33) (H region methotrexate resistance protein) PTR1 HMTXR L1063.01 LmjF23.0270 LmjF_23_0270 Leishmania major TR37163_c1_g2_i1 O13821 VPS27_SCHPO 8.00E-12 GO:0033565; GO:0031321; GO:0005829; GO:0006897; GO:0010008; GO:0006900; GO:0046872; GO:0005634; GO:0032266; GO:0005628; GO:0045053; GO:0043328; GO:0043130 ESCRT-0 complex; ascospore-type prospore assembly; cytosol; endocytosis; endosome membrane; membrane budding; metal ion binding; nucleus; phosphatidylinositol-3-phosphate binding; prospore membrane; protein retention in Golgi apparatus; protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ubiquitin binding IPR008942; IPR017073; IPR003903; IPR002014; IPR018205; IPR027427; IPR000306; IPR017455; IPR011011; IPR013083; Vacuolar protein sorting-associated protein 27 (Suppressor of ste12 deletion protein 4) sst4 vps27 SPAC19A8.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR37163_c1_g2_i2 Q8BUB4 WDFY2_MOUSE 2.00E-173 GO:0046872 metal ion binding IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; IPR000306; IPR017455; IPR013083; WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain-containing protein 2) Wdfy2 Mus musculus (Mouse) TR37163_c1_g2_i3 Q09715 TUP11_SCHPO 1.00E-08 GO:0006342; GO:0005829; GO:0042393; GO:0045014; GO:0000122; GO:0000790; GO:0043234; GO:0003714; GO:0006351 "chromatin silencing; cytosol; histone binding; negative regulation of transcription by glucose; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; protein complex; transcription corepressor activity; transcription, DNA-dependent" IPR020472; IPR013890; IPR015943; IPR001680; IPR019775; IPR017986; Transcriptional repressor tup11 tup11 SPAC18B11.10 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR37164_c9_g3_i5 Q80X72 LRC15_MOUSE 6.00E-13 GO:0016021 integral to membrane IPR000483; IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing protein 15 Lrrc15 Mus musculus (Mouse) TR37169_c3_g1_i1 P25291 GP2_CANFA 3.00E-06 GO:0031225; GO:0005576; GO:0005886 anchored to membrane; extracellular region; plasma membrane IPR001507; IPR017977; Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) GP2 Canis familiaris (Dog) (Canis lupus familiaris) TR37169_c4_g1_i1 P55259 GP2_HUMAN 2.00E-14 GO:0031225; GO:0003823; GO:0002412; GO:0016324; GO:0005576 anchored to membrane; antigen binding; antigen transcytosis by M cells in mucosal-associated lymphoid tissue; apical plasma membrane; extracellular region IPR001507; IPR017977; Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) (ZAP75) GP2 Homo sapiens (Human) TR37169_c4_g2_i1 P19218 GP2_RAT 3.00E-12 GO:0031225; GO:0005576; GO:0005886 anchored to membrane; extracellular region; plasma membrane IPR001507; IPR017977; Pancreatic secretory granule membrane major glycoprotein GP2 (Glycoprotein 80) (gp80) (Pancreatic zymogen granule membrane protein GP-2) Gp2 Rattus norvegicus (Rat) TR37169_c5_g1_i1 Q8N2E2 VWDE_HUMAN 4.00E-32 GO:0005576 extracellular region IPR000742; IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) TR37169_c6_g5_i1 Q6DFV8 VWDE_MOUSE 3.00E-07 GO:0005576 extracellular region IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) TR37170_c0_g1_i1 Q03278 PO21_NASVI 6.00E-11 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR000477; IPR007087; IPR015880; Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 (Retrovirus-related Pol polyprotein from type I retrotransposable element R2) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] (Fragment) Nasonia vitripennis (Parasitic wasp) TR37170_c0_g2_i1 Q9UNW1 MINP1_HUMAN 4.00E-47 GO:0003993; GO:0034417; GO:0030282; GO:0005788; GO:0052826; GO:0043647; GO:0008969; GO:0006797 acid phosphatase activity; bisphosphoglycerate 3-phosphatase activity; bone mineralization; endoplasmic reticulum lumen; inositol hexakisphosphate 2-phosphatase activity; inositol phosphate metabolic process; phosphohistidine phosphatase activity; polyphosphate metabolic process IPR000560; IPR016274; "Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80) (Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase) (Ins(1,3,4,5)P(4) 3-phosphatase)" MINPP1 MIPP UNQ900/PRO1917 Homo sapiens (Human) TR37170_c0_g2_i7 Q9UNW1 MINP1_HUMAN 7.00E-44 GO:0003993; GO:0034417; GO:0030282; GO:0005788; GO:0052826; GO:0043647; GO:0008969; GO:0006797 acid phosphatase activity; bisphosphoglycerate 3-phosphatase activity; bone mineralization; endoplasmic reticulum lumen; inositol hexakisphosphate 2-phosphatase activity; inositol phosphate metabolic process; phosphohistidine phosphatase activity; polyphosphate metabolic process IPR000560; IPR016274; "Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80) (Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase) (Ins(1,3,4,5)P(4) 3-phosphatase)" MINPP1 MIPP UNQ900/PRO1917 Homo sapiens (Human) TR37170_c0_g2_i8 P08091 PPA1_SCHPO 5.00E-10 GO:0003993; GO:0030287; GO:0016036; GO:0005783; GO:0009897; GO:0005576; GO:0009277; GO:0046434; GO:1900922; GO:1901036; GO:1900928; GO:1900931; GO:1900925 acid phosphatase activity; cell wall-bounded periplasmic space; cellular response to phosphate starvation; endoplasmic reticulum; external side of plasma membrane; extracellular region; fungal-type cell wall; organophosphate catabolic process; positive regulation of L-glutamate import; positive regulation of L-glutamine import; positive regulation of L-threonine import; positive regulation of L-tyrosine import; positive regulation of glycine import IPR000560; IPR016274; Acid phosphatase (EC 3.1.3.2) pho1 SPBP4G3.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR37172_c0_g2_i1 Q9CYF5 WBS16_MOUSE 2.00E-66 GO:0005087; GO:0005739 Ran guanyl-nucleotide exchange factor activity; mitochondrion IPR009091; IPR000408; Williams-Beuren syndrome chromosomal region 16 protein homolog Wbscr16 Mus musculus (Mouse) TR37172_c0_g2_i2 Q5GLZ8 HERC4_HUMAN 3.00E-11 GO:0030154; GO:0005737; GO:0005829; GO:0005634; GO:0042787; GO:0007283; GO:0004842 cell differentiation; cytoplasm; cytosol; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; spermatogenesis; ubiquitin-protein ligase activity IPR000569; IPR009091; IPR000408; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HERC4 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 4) HERC4 KIAA1593 Homo sapiens (Human) TR37172_c0_g3_i1 Q9CYF5 WBS16_MOUSE 3.00E-48 GO:0005087; GO:0005739 Ran guanyl-nucleotide exchange factor activity; mitochondrion IPR009091; IPR000408; Williams-Beuren syndrome chromosomal region 16 protein homolog Wbscr16 Mus musculus (Mouse) TR37173_c1_g1_i3 Q95SX7 RTBS_DROME 6.00E-35 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR37173_c3_g1_i1 Q9NUV9 GIMA4_HUMAN 1.00E-30 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR37175_c0_g1_i1 P86854 PLCL_MYTGA 2.00E-10 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR37175_c0_g1_i5 P86854 PLCL_MYTGA 2.00E-10 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR37176_c1_g1_i1 Q8QZX2 HAUS3_MOUSE 3.00E-26 GO:0070652; GO:0051301; GO:0005813; GO:0051297; GO:0005737; GO:0005874; GO:0007067; GO:0005819; GO:0051225 HAUS complex; cell division; centrosome; centrosome organization; cytoplasm; microtubule; mitosis; spindle; spindle assembly IPR026206; HAUS augmin-like complex subunit 3 Haus3 Mus musculus (Mouse) TR37176_c1_g1_i4 Q68CZ6 HAUS3_HUMAN 2.00E-42 GO:0070652; GO:0051301; GO:0005813; GO:0051297; GO:0005737; GO:0005874; GO:0007067; GO:0005819; GO:0051225 HAUS complex; cell division; centrosome; centrosome organization; cytoplasm; microtubule; mitosis; spindle; spindle assembly IPR026206; HAUS augmin-like complex subunit 3 HAUS3 C4orf15 Homo sapiens (Human) TR37178_c0_g2_i1 P39086 GRIK1_HUMAN 3.00E-50 GO:0030534; GO:0048266; GO:0030054; GO:0007417; GO:0030425; GO:0005234; GO:0005887; GO:0015277; GO:0032983; GO:0051967; GO:0014054; GO:0032230; GO:0045211; GO:0042734; GO:0060079; GO:0060080; GO:0051966; GO:0007268; GO:0035249 "adult behavior; behavioral response to pain; cell junction; central nervous system development; dendrite; extracellular-glutamate-gated ion channel activity; integral to plasma membrane; kainate selective glutamate receptor activity; kainate selective glutamate receptor complex; negative regulation of synaptic transmission, glutamatergic; positive regulation of gamma-aminobutyric acid secretion; positive regulation of synaptic transmission, GABAergic; postsynaptic membrane; presynaptic membrane; regulation of excitatory postsynaptic membrane potential; regulation of inhibitory postsynaptic membrane potential; regulation of synaptic transmission, glutamatergic; synaptic transmission; synaptic transmission, glutamatergic" IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; "Glutamate receptor ionotropic, kainate 1 (GluK1) (Excitatory amino acid receptor 3) (EAA3) (Glutamate receptor 5) (GluR-5) (GluR5)" GRIK1 GLUR5 Homo sapiens (Human) TR37180_c0_g1_i1 Q91974 IKBA_CHICK 1.00E-36 GO:0002755; GO:0035419; GO:0007250; GO:0005737; GO:0045087; GO:0048145; GO:0035681; GO:0034134; GO:0035682; GO:0034138; GO:0034142; GO:0034146; GO:0034154 MyD88-dependent toll-like receptor signaling pathway; activation of MAPK activity involved in innate immune response; activation of NF-kappaB-inducing kinase activity; cytoplasm; innate immune response; regulation of fibroblast proliferation; toll-like receptor 15 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 21 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 7 signaling pathway IPR002110; IPR020683; NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (REL-associated protein pp40) NFKBIA IKBA Gallus gallus (Chicken) TR37181_c0_g1_i1 Q8JHF0 PEN2_DANRE 9.00E-37 GO:0007219; GO:0016021; GO:0043524 Notch signaling pathway; integral to membrane; negative regulation of neuron apoptotic process IPR019379; Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2 homolog) psenen pen2 zgc:109727 Danio rerio (Zebrafish) (Brachydanio rerio) TR37182_c3_g1_i2 Q9NVR7 TBCC1_HUMAN 1.00E-128 GO:0000902; GO:0005737; GO:0007010; GO:0051684; GO:0051661; GO:0030334; GO:0008360; GO:0031616 cell morphogenesis; cytoplasm; cytoskeleton organization; maintenance of Golgi location; maintenance of centrosome location; regulation of cell migration; regulation of cell shape; spindle pole centrosome IPR013912; IPR017901; IPR016098; IPR006599; IPR012945; TBCC domain-containing protein 1 TBCCD1 Homo sapiens (Human) TR37182_c3_g1_i3 Q9NVR7 TBCC1_HUMAN 2.00E-84 GO:0000902; GO:0005737; GO:0007010; GO:0051684; GO:0051661; GO:0030334; GO:0008360; GO:0031616 cell morphogenesis; cytoplasm; cytoskeleton organization; maintenance of Golgi location; maintenance of centrosome location; regulation of cell migration; regulation of cell shape; spindle pole centrosome IPR013912; IPR017901; IPR016098; IPR006599; IPR012945; TBCC domain-containing protein 1 TBCCD1 Homo sapiens (Human) TR37184_c2_g1_i1 Q26534 CATL_SCHMA 1.00E-99 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L (EC 3.4.22.15) (SMCL1) CL1 Schistosoma mansoni (Blood fluke) TR37184_c2_g1_i2 P22085 CYTX_ONCVO 5.00E-06 GO:0004869 cysteine-type endopeptidase inhibitor activity IPR027214; IPR000010; IPR020381; IPR018073; Onchocystatin (Cysteine proteinase inhibitor OV7) Onchocerca volvulus TR37185_c3_g1_i2 Q29B72 CRBN_DROPS 1.00E-43 Protein cereblon homolog GA17779 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR37185_c3_g1_i4 P0CF65 CRBN_CHICK 5.00E-129 GO:0004176; GO:0031464; GO:0005737; GO:0005634; GO:0043161; GO:0016567 ATP-dependent peptidase activity; Cul4A-RING ubiquitin ligase complex; cytoplasm; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination IPR003111; IPR015947; Protein modification; protein ubiquitination. Protein cereblon CRBN Gallus gallus (Chicken) TR37187_c6_g1_i1 Q9BQ70 TCF25_HUMAN 1.00E-138 GO:0003677; GO:0007507; GO:0005739; GO:0000122; GO:0005730; GO:0003700; GO:0006351 P21673 "DNA binding; heart development; mitochondrion; negative regulation of transcription from RNA polymerase II promoter; nucleolus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR006994; IPR011990; Transcription factor 25 (TCF-25) (Nuclear localized protein 1) TCF25 KIAA1049 NULP1 FKSG26 Homo sapiens (Human) TR37187_c6_g1_i2 Q8T2A4 TCF25_DICDI 2.00E-51 GO:0003677; GO:0000122; GO:0005634; GO:0003700; GO:0006351 "DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR011989; IPR006994; Transcription factor 25 homolog (TCF-25) tcf25 DDB_G0274217 Dictyostelium discoideum (Slime mold) TR37190_c3_g2_i6 P22682 CBL_MOUSE 0 GO:0045453; GO:0005509; GO:0007166; GO:0005737; GO:0043066; GO:0005634; GO:0005886; GO:0014068; GO:0006468; GO:0004871; GO:0004842; GO:0008270 Q6Q899; P00533 bone resorption; calcium ion binding; cell surface receptor signaling pathway; cytoplasm; negative regulation of apoptotic process; nucleus; plasma membrane; positive regulation of phosphatidylinositol 3-kinase cascade; protein phosphorylation; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR024162; IPR014741; IPR003153; IPR014742; IPR024159; IPR011992; IPR000980; IPR009060; IPR015940; IPR000449; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (Signal transduction protein CBL) Cbl Mus musculus (Mouse) TR37191_c4_g1_i3 Q8TB52 FBX30_HUMAN 6.00E-13 GO:0004842; GO:0008270 ubiquitin-protein ligase activity; zinc ion binding IPR001810; IPR013323; IPR008974; IPR001293; F-box only protein 30 FBXO30 FBX30 Homo sapiens (Human) TR37192_c0_g1_i12 Q1RMS8 FBX25_BOVIN 8.00E-24 GO:0019005; GO:0005634; GO:0016567 SCF ubiquitin ligase complex; nucleus; protein ubiquitination IPR001810; Protein modification; protein ubiquitination. F-box only protein 25 FBXO25 Bos taurus (Bovine) TR37192_c0_g1_i16 Q969P5 FBX32_HUMAN 2.00E-13 GO:0030018; GO:0005634; GO:0016567; GO:0014894 O00303 Z disc; nucleus; protein ubiquitination; response to denervation involved in regulation of muscle adaptation IPR001810; Protein modification; protein ubiquitination. F-box only protein 32 (Atrogin-1) (Muscle atrophy F-box protein) (MAFbx) FBXO32 Homo sapiens (Human) TR37192_c0_g1_i3 Q969P5 FBX32_HUMAN 1.00E-28 GO:0030018; GO:0005634; GO:0016567; GO:0014894 O00303 Z disc; nucleus; protein ubiquitination; response to denervation involved in regulation of muscle adaptation IPR001810; Protein modification; protein ubiquitination. F-box only protein 32 (Atrogin-1) (Muscle atrophy F-box protein) (MAFbx) FBXO32 Homo sapiens (Human) TR37192_c0_g1_i9 Q969P5 FBX32_HUMAN 7.00E-30 GO:0030018; GO:0005634; GO:0016567; GO:0014894 O00303 Z disc; nucleus; protein ubiquitination; response to denervation involved in regulation of muscle adaptation IPR001810; Protein modification; protein ubiquitination. F-box only protein 32 (Atrogin-1) (Muscle atrophy F-box protein) (MAFbx) FBXO32 Homo sapiens (Human) TR37194_c0_g1_i1 P51049 MR1BB_DANRE 3.00E-23 GO:0016021; GO:0008502; GO:0005886; GO:0048511 integral to membrane; melatonin receptor activity; plasma membrane; rhythmic process IPR000276; IPR017452; IPR002278; IPR027459; IPR000025; Melatonin receptor type 1B-B (Mel-1B-R-B) (Mel1b receptor B) (Melatonin receptor Mel1b Z2.6-4) (zMel1b-1) mtnr1bb mel1br mtnr1br mtnr1br-2 si:ch211-214k5.4 si:ch211-224h1.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR37194_c0_g1_i2 P48039 MTR1A_HUMAN 5.00E-24 GO:0007187; GO:0007623; GO:0042562; GO:0005887; GO:0007617; GO:0008502; GO:0097159; GO:0030828; GO:0043235 P49286; O76081 "G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; circadian rhythm; hormone binding; integral to plasma membrane; mating behavior; melatonin receptor activity; organic cyclic compound binding; positive regulation of cGMP biosynthetic process; receptor complex" IPR000276; IPR017452; IPR002278; IPR000025; Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor) MTNR1A Homo sapiens (Human) TR37194_c0_g1_i3 P51476 OPSP_COLLI 5.00E-16 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR002206; IPR027430; Pinopsin (Pineal gland-specific opsin) (P-opsin) (Pineal opsin) Columba livia (Domestic pigeon) TR37194_c0_g1_i4 Q16950 5HTB1_APLCA 3.00E-08 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR000276; IPR017452; 5-hydroxytryptamine receptor 1 (5-HTB1) (Serotonin receptor 1) 5HTB1 Aplysia californica (California sea hare) TR37195_c4_g1_i1 P29121 PCSK4_MOUSE 3.00E-31 GO:0002080; GO:0007340; GO:0007339; GO:0005788; GO:0006508; GO:0004252; GO:0048240 acrosomal membrane; acrosome reaction; binding of sperm to zona pellucida; endoplasmic reticulum lumen; proteolysis; serine-type endopeptidase activity; sperm capacitation IPR008979; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 4 (EC 3.4.21.-) (KEX2-like endoprotease 3) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3) Pcsk4 Nec-3 Nec3 Mus musculus (Mouse) TR37195_c6_g1_i1 P29145 NECB_HYDVU 9.00E-36 GO:0006508; GO:0004252 proteolysis; serine-type endopeptidase activity IPR008979; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; PC3-like endoprotease variant B (EC 3.4.21.-) (SPC3) Hydra vulgaris (Hydra) (Hydra attenuata) TR37199_c0_g2_i2 Q8VD66 ABHD4_MOUSE 1.00E-128 GO:0016787; GO:0016042 hydrolase activity; lipid catabolic process IPR000073; Abhydrolase domain-containing protein 4 (EC 3.1.1.-) (Alpha/beta-hydrolase 4) (Lyso-N-acylphosphatidylethanolamine lipase) Abhd4 Mus musculus (Mouse) TR3720_c0_g1_i1 P49190 PTH2R_HUMAN 8.00E-09 GO:0005887; GO:0004991 integral to plasma membrane; parathyroid hormone receptor activity IPR017981; IPR001879; IPR000832; IPR017983; Parathyroid hormone 2 receptor (PTH2 receptor) PTH2R PTHR2 Homo sapiens (Human) TR37202_c4_g1_i1 O60290 ZN862_HUMAN 1.00E-21 GO:0046872; GO:0003676; GO:0005634; GO:0006355; GO:0006351 "metal ion binding; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR008906; IPR026613; IPR001909; IPR012337; IPR006580; Zinc finger protein 862 ZNF862 KIAA0543 Homo sapiens (Human) TR37202_c6_g1_i1 O18326 HUNB_BOMMO 3.00E-45 GO:0003677; GO:0046872; GO:0005634; GO:0040034; GO:0035282; GO:0000981; GO:0006366 "DNA binding; metal ion binding; nucleus; regulation of development, heterochronic; segmentation; sequence-specific DNA binding RNA polymerase II transcription factor activity; transcription from RNA polymerase II promoter" IPR027775; IPR027742; IPR007087; IPR015880; IPR013087; Protein hunchback (Fragment) hb Bombyx mori (Silk moth) TR37202_c9_g1_i1 Q13422 IKZF1_HUMAN 2.00E-14 GO:0030183; GO:0003677; GO:0048541; GO:0030217; GO:0007049; GO:0005721; GO:0016568; GO:0005737; GO:0030900; GO:0048732; GO:0048535; GO:0007498; GO:0046872; GO:0001779; GO:0000122; GO:0003676; GO:0005634; GO:0051138; GO:0040018; GO:0045660; GO:0045944; GO:0060041; GO:0043565; GO:0003700; GO:0048538; GO:0006351 "B cell differentiation; DNA binding; Peyer's patch development; T cell differentiation; cell cycle; centromeric heterochromatin; chromatin modification; cytoplasm; forebrain development; gland development; lymph node development; mesoderm development; metal ion binding; natural killer cell differentiation; negative regulation of transcription from RNA polymerase II promoter; nucleic acid binding; nucleus; positive regulation of NK T cell differentiation; positive regulation of multicellular organism growth; positive regulation of neutrophil differentiation; positive regulation of transcription from RNA polymerase II promoter; retina development in camera-type eye; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; thymus development; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) IKZF1 IK1 IKAROS LYF1 ZNFN1A1 Homo sapiens (Human) TR37207_c15_g1_i1 Q04202 TCB2_CAEBR 2.00E-19 GO:0003677; GO:0015074; GO:0005634; GO:0004803; GO:0006313 "DNA binding; DNA integration; nucleus; transposase activity; transposition, DNA-mediated" IPR002492; Transposable element Tcb2 transposase Caenorhabditis briggsae TR37207_c16_g1_i3 P34257 TC3A_CAEEL 4.00E-14 GO:0003677; GO:0015074; GO:0005634; GO:0004803; GO:0006313 "DNA binding; DNA integration; nucleus; transposase activity; transposition, DNA-mediated" IPR009057; IPR025898; IPR002492; Transposable element Tc3 transposase tc3a B0303.5 Caenorhabditis elegans TR37208_c0_g1_i1 P43254 COP1_ARATH 9.00E-07 GO:0080008; GO:0006281; GO:0046283; GO:0005737; GO:0009649; GO:0016604; GO:0000152; GO:0009640; GO:0048573; GO:0009585; GO:0010119; GO:0009641; GO:0009647; GO:0004842; GO:0008270 Itself; Q38843; Q9SPL2; Q39057; Q9SK53; Q9LJD7; Q43125; Q96524; Q9FE22; O24646; Q8W191-2; Q9M0K4; Q9SJL7; Q9SYX2; Q9LJR3; Q94BM7; Q9SID1; Q9FN03 "Cul4-RING ubiquitin ligase complex; DNA repair; anthocyanin-containing compound metabolic process; cytoplasm; entrainment of circadian clock; nuclear body; nuclear ubiquitin ligase complex; photomorphogenesis; photoperiodism, flowering; red, far-red light phototransduction; regulation of stomatal movement; shade avoidance; skotomorphogenesis; ubiquitin-protein ligase activity; zinc ion binding" IPR015943; IPR001680; IPR019775; IPR017986; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase COP1 (EC 6.3.2.-) (Constitutive photomorphogenesis protein 1) COP1 At2g32950 T21L14.11 Arabidopsis thaliana (Mouse-ear cress) TR37208_c0_g1_i2 Q4KLY4 RING2_RAT 3.00E-116 GO:0071339; GO:0035102; GO:0009948; GO:0003682; GO:0001702; GO:0035518; GO:0000278; GO:0000122; GO:0016604; GO:0001739; GO:0006351; GO:0000151; GO:0004842; GO:0008270 "MLL1 complex; PRC1 complex; anterior/posterior axis specification; chromatin binding; gastrulation with mouth forming second; histone H2A monoubiquitination; mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; nuclear body; sex chromatin; transcription, DNA-dependent; ubiquitin ligase complex; ubiquitin-protein ligase activity; zinc ion binding" IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RING2 (EC 6.3.2.-) (RING finger protein 1B) (RING1b) (RING finger protein 2) Rnf2 Ring1b Rattus norvegicus (Rat) TR37209_c0_g1_i1 Q2TAW0 CNDG2_XENLA 2.00E-102 GO:0051301; GO:0030261; GO:0007067; GO:0005634 cell division; chromosome condensation; mitosis; nucleus IPR011989; IPR016024; IPR024741; Condensin-2 complex subunit G2 (Chromosome-associated protein G2) (Non-SMC condensin II complex subunit G2) (XCAP-G2) ncapg2 Xenopus laevis (African clawed frog) TR37211_c3_g1_i4 Q1RMU8 NPY1R_BOVIN 5.00E-10 GO:0007631; GO:0006006; GO:0016021; GO:0007626; GO:0003151; GO:0001602; GO:0001601; GO:0005886; GO:0008217; GO:0040014; GO:0019233 feeding behavior; glucose metabolic process; integral to membrane; locomotory behavior; outflow tract morphogenesis; pancreatic polypeptide receptor activity; peptide YY receptor activity; plasma membrane; regulation of blood pressure; regulation of multicellular organism growth; sensory perception of pain IPR000276; IPR017452; IPR000351; IPR000611; Neuropeptide Y receptor type 1 (NPY1-R) NPY1R Bos taurus (Bovine) TR37212_c0_g1_i1 P25867 UBCD1_DROME 2.00E-92 GO:0005524; GO:0051276; GO:0001751; GO:0008054; GO:0048132; GO:0030718; GO:0007140; GO:0005875; GO:0007067; GO:0016322; GO:0045676; GO:0031647; GO:0007286; GO:0004842 ATP binding; chromosome organization; compound eye photoreceptor cell differentiation; cyclin catabolic process; female germ-line stem cell division; germ-line stem cell maintenance; male meiosis; microtubule associated complex; mitosis; neuron remodeling; regulation of R7 cell differentiation; regulation of protein stability; spermatid development; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2-17 kDa (EC 6.3.2.19) (Protein effete) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) eff UbcD1 CG7425 Drosophila melanogaster (Fruit fly) TR37212_c0_g2_i1 P25867 UBCD1_DROME 1.00E-93 GO:0005524; GO:0051276; GO:0001751; GO:0008054; GO:0048132; GO:0030718; GO:0007140; GO:0005875; GO:0007067; GO:0016322; GO:0045676; GO:0031647; GO:0007286; GO:0004842 ATP binding; chromosome organization; compound eye photoreceptor cell differentiation; cyclin catabolic process; female germ-line stem cell division; germ-line stem cell maintenance; male meiosis; microtubule associated complex; mitosis; neuron remodeling; regulation of R7 cell differentiation; regulation of protein stability; spermatid development; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2-17 kDa (EC 6.3.2.19) (Protein effete) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) eff UbcD1 CG7425 Drosophila melanogaster (Fruit fly) TR37214_c1_g1_i1 Q7Q732 DHRS7_ANOGA 6.00E-40 GO:0016021; GO:0016491; GO:0005778 integral to membrane; oxidoreductase activity; peroxisomal membrane IPR002198; IPR002347; IPR016040; IPR020904; Dehydrogenase/reductase SDR family protein 7-like (EC 1.1.-.-) AGAP005532 Anopheles gambiae (African malaria mosquito) TR37214_c1_g1_i2 Q9Y394 DHRS7_HUMAN 2.00E-71 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Dehydrogenase/reductase SDR family member 7 (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) DHRS7 DHRS7A RETSDR4 CGI-86 UNQ285/PRO3448 Homo sapiens (Human) TR37214_c1_g1_i3 O57314 DHB12_ANAPL 1.00E-06 GO:0005789; GO:0004303; GO:0006703; GO:0016021 endoplasmic reticulum membrane; estradiol 17-beta-dehydrogenase activity; estrogen biosynthetic process; integral to membrane IPR002198; IPR002347; IPR016040; IPR020904; Steroid biosynthesis; estrogen biosynthesis. Estradiol 17-beta-dehydrogenase 12 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) HSD17B12 SPM2 Anas platyrhynchos (Domestic duck) (Anas boschas) TR37214_c1_g1_i4 O18404 HCD2_DROME 8.00E-08 GO:0047015; GO:0003857; GO:0047022; GO:0018454; GO:0006637; GO:0008209; GO:0005829; GO:0008205; GO:0004303; GO:0008210; GO:0006631; GO:0005811; GO:0005875; GO:0005739; GO:0008033; GO:0047035; GO:0030283 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity; 3-hydroxyacyl-CoA dehydrogenase activity; 7-beta-hydroxysteroid dehydrogenase (NADP+) activity; acetoacetyl-CoA reductase activity; acyl-CoA metabolic process; androgen metabolic process; cytosol; ecdysone metabolic process; estradiol 17-beta-dehydrogenase activity; estrogen metabolic process; fatty acid metabolic process; lipid particle; microtubule associated complex; mitochondrion; tRNA processing; testosterone dehydrogenase (NAD+) activity; testosterone dehydrogenase [NAD(P)] activity IPR002198; IPR002347; IPR016040; IPR020904; 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Scully protein) (Type II HADH) scu CG7113 Drosophila melanogaster (Fruit fly) TR37215_c1_g1_i1 Q8N5D0 WDTC1_HUMAN 0 GO:0055082; GO:0032869; GO:0005829; GO:0004857; GO:0006006; GO:0001701; GO:0043231; GO:0035264; GO:0045717; GO:0000122; GO:0005634; GO:0008361 cellular chemical homeostasis; cellular response to insulin stimulus; cytosol; enzyme inhibitor activity; glucose metabolic process; in utero embryonic development; intracellular membrane-bounded organelle; multicellular organism growth; negative regulation of fatty acid biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; nucleus; regulation of cell size IPR013026; IPR011990; IPR013105; IPR015943; IPR001680; IPR017986; WD and tetratricopeptide repeats protein 1 WDTC1 KIAA1037 Homo sapiens (Human) TR37215_c1_g1_i2 Q80ZK9 WDTC1_MOUSE 5.00E-144 GO:0055082; GO:0032869; GO:0005829; GO:0004857; GO:0006006; GO:0001701; GO:0035264; GO:0045717; GO:0000122; GO:0005634; GO:0008361 cellular chemical homeostasis; cellular response to insulin stimulus; cytosol; enzyme inhibitor activity; glucose metabolic process; in utero embryonic development; multicellular organism growth; negative regulation of fatty acid biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; nucleus; regulation of cell size IPR013026; IPR011990; IPR013105; IPR015943; IPR001680; IPR017986; WD and tetratricopeptide repeats protein 1 Wdtc1 Gm695 Mus musculus (Mouse) TR37217_c0_g1_i1 Q68DU8 KCD16_HUMAN 7.00E-29 GO:0030054; GO:0045211; GO:0042734; GO:0051260; GO:0043235; GO:0008277 cell junction; postsynaptic membrane; presynaptic membrane; protein homooligomerization; receptor complex; regulation of G-protein coupled receptor protein signaling pathway IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein KCTD16 (Potassium channel tetramerization domain-containing protein 16) KCTD16 KIAA1317 Homo sapiens (Human) TR37218_c1_g1_i2 Q6P4W0 F175B_XENTR 4.00E-13 GO:0070552; GO:0031593 BRISC complex; polyubiquitin binding IPR023238; IPR023240; BRISC complex subunit Abro1 (Abraxas brother protein 1) (Protein FAM175B) fam175b abro1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37220_c5_g2_i1 P83425 HIP_MYTED 1.00E-09 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR37225_c4_g2_i1 O75410 TACC1_HUMAN 4.00E-29 GO:0007049; GO:0051301; GO:0021987; GO:0005737; GO:0022027; GO:0045111; GO:0015630; GO:0000226; GO:0005815; GO:0022008; GO:0005634; GO:0032886 Q96GD4; Q14008; Q9UK45; P62308; Q8NHU6; O95619 cell cycle; cell division; cerebral cortex development; cytoplasm; interkinetic nuclear migration; intermediate filament cytoskeleton; microtubule cytoskeleton; microtubule cytoskeleton organization; microtubule organizing center; neurogenesis; nucleus; regulation of microtubule-based process IPR007707; Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) TACC1 KIAA1103 Homo sapiens (Human) TR37225_c4_g2_i3 O95359 TACC2_HUMAN 2.00E-27 GO:0005794; GO:0030953; GO:0021987; GO:0022027; GO:0005815; GO:0022008; GO:0035257; GO:0005730; GO:0032886 Golgi apparatus; astral microtubule organization; cerebral cortex development; interkinetic nuclear migration; microtubule organizing center; neurogenesis; nuclear hormone receptor binding; nucleolus; regulation of microtubule-based process IPR007707; Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) TACC2 Homo sapiens (Human) TR37225_c4_g2_i4 Q6Y685 TACC1_MOUSE 1.00E-28 GO:0007049; GO:0051301; GO:0021987; GO:0005737; GO:0022027; GO:0000226; GO:0005815; GO:0022008; GO:0005634; GO:0032886 cell cycle; cell division; cerebral cortex development; cytoplasm; interkinetic nuclear migration; microtubule cytoskeleton organization; microtubule organizing center; neurogenesis; nucleus; regulation of microtubule-based process IPR007707; Transforming acidic coiled-coil-containing protein 1 Tacc1 Mus musculus (Mouse) TR37225_c9_g1_i1 Q0VGW6 S12A9_XENLA 0 GO:0016021; GO:0005886; GO:0055085 integral to membrane; plasma membrane; transmembrane transport IPR004841; Solute carrier family 12 member 9 (Cation-chloride cotransporter-interacting protein 1) slc12a9 cip1 Xenopus laevis (African clawed frog) TR37227_c3_g2_i1 Q87PH8 NPD_VIBPA 5.00E-34 GO:0070403; GO:0034979; GO:0005737; GO:0036047; GO:0036049; GO:0036054; GO:0036055; GO:0008270 NAD+ binding; NAD-dependent protein deacetylase activity; cytoplasm; peptidyl-lysine demalonylation; peptidyl-lysine desuccinylation; protein-malonyllysine demalonylase activity; protein-succinyllysine desuccinylase activity; zinc ion binding IPR003000; IPR026591; IPR027546; IPR026590; NAD-dependent protein deacylase (EC 3.5.1.-) (Regulatory protein SIR2 homolog) cobB VP1524 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) TR37227_c3_g2_i2 Q5R6G3 SIR5_PONAB 4.00E-147 GO:0070403; GO:0005758; GO:0005759; GO:0006476; GO:0036054; GO:0036055; GO:0008270 NAD+ binding; mitochondrial intermembrane space; mitochondrial matrix; protein deacetylation; protein-malonyllysine demalonylase activity; protein-succinyllysine desuccinylase activity; zinc ion binding IPR003000; IPR026591; IPR027546; IPR026590; "NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 3.5.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)" SIRT5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37227_c3_g2_i6 F7D4X9 SIR5_MONDO 3.00E-108 GO:0070403; GO:0005758; GO:0005759; GO:0006476; GO:0036054; GO:0036055; GO:0008270 NAD+ binding; mitochondrial intermembrane space; mitochondrial matrix; protein deacetylation; protein-malonyllysine demalonylase activity; protein-succinyllysine desuccinylase activity; zinc ion binding IPR003000; IPR026591; IPR027546; IPR026590; "NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 3.5.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)" SIRT5 Monodelphis domestica (Gray short-tailed opossum) TR37228_c2_g1_i1 Q84JE8 ZDP_ARATH 4.00E-06 GO:0003677; GO:0006281; GO:0016301; GO:0005654; GO:0098506; GO:0046403; GO:0006355; GO:0006351; GO:0008270 "DNA binding; DNA repair; kinase activity; nucleoplasm; polynucleotide 3' dephosphorylation; polynucleotide 3'-phosphatase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR023214; IPR006549; IPR013954; IPR006551; IPR001510; Polynucleotide 3'-phosphatase ZDP (EC 3.1.3.32) (DNA nick sensor protein) ZDP At3g14890 K15M2.3 Arabidopsis thaliana (Mouse-ear cress) TR37229_c5_g1_i1 P78424 PO6F2_HUMAN 1.00E-86 GO:0007417; GO:0007402; GO:0005634; GO:0043565; GO:0003700; GO:0006366; GO:0007601 central nervous system development; ganglion mother cell fate determination; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; visual perception IPR001356; IPR009057; IPR010982; IPR013847; IPR015585; IPR000327; "POU domain, class 6, transcription factor 2 (Retina-derived POU domain factor 1) (RPF-1)" POU6F2 RPF1 Homo sapiens (Human) TR37230_c0_g2_i1 Q86UF1 TSN33_HUMAN 2.00E-27 GO:0016021 integral to membrane IPR000301; IPR018499; IPR008952; Tetraspanin-33 (Tspan-33) (Penumbra) (hPen) (Proerythroblast new membrane) TSPAN33 PEN Homo sapiens (Human) TR37231_c0_g2_i1 P02717 ACHD_CHICK 6.00E-11 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit delta CHNRD Gallus gallus (Chicken) TR37231_c2_g1_i4 Q6ZRF8 RN207_HUMAN 5.00E-91 GO:0005622; GO:0008270 intracellular; zinc ion binding IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) TR37231_c3_g4_i1 Q60MF5 RN207_CAEBR 6.00E-11 GO:0005622; GO:0008270 intracellular; zinc ion binding IPR000315; IPR001841; IPR013083; Probable RING finger protein 207 homolog CBG23170 Caenorhabditis briggsae TR37231_c3_g4_i3 Q6ZRF8 RN207_HUMAN 7.00E-23 GO:0005622; GO:0008270 intracellular; zinc ion binding IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) TR37231_c4_g1_i1 Q23022 ACH5_CAEEL 6.00E-09 GO:0015464; GO:0004889; GO:0030054; GO:0005230; GO:0016021; GO:0040011; GO:0007274; GO:0043005; GO:0045211; GO:0046662 acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; cell junction; extracellular ligand-gated ion channel activity; integral to membrane; locomotion; neuromuscular synaptic transmission; neuron projection; postsynaptic membrane; regulation of oviposition IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha-type unc-38 (Uncoordinated protein 38) unc-38 F21F3.5 Caenorhabditis elegans TR37232_c1_g1_i1 Q6P575 YV019_HUMAN 1.00E-22 GO:0005975; GO:0004553 "carbohydrate metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds" IPR008979; IPR006104; Putative uncharacterized protein LOC91316 Homo sapiens (Human) TR37232_c2_g1_i1 Q48846 BGAL_LACSK 1.00E-11 GO:0004565; GO:0005975 beta-galactosidase activity; carbohydrate metabolic process IPR008979; IPR006101; IPR013812; IPR023232; IPR023230; IPR006102; IPR006104; IPR006103; IPR013781; IPR017853; Beta-galactosidase large subunit (Beta-gal large subunit) (EC 3.2.1.23) (Lactase large subunit) lacL Lactobacillus sakei TR37232_c2_g2_i1 Q4FAT7 BGLR_PIG 5.00E-88 GO:0004566; GO:0005975; GO:0005764 beta-glucuronidase activity; carbohydrate metabolic process; lysosome IPR008979; IPR006101; IPR013812; IPR023232; IPR023230; IPR006102; IPR006104; IPR006103; IPR013781; IPR017853; Beta-glucuronidase (EC 3.2.1.31) GUSB Sus scrofa (Pig) TR37232_c2_g2_i2 O18835 BGLR_CANFA 1.00E-88 GO:0004566; GO:0005975; GO:0005764 beta-glucuronidase activity; carbohydrate metabolic process; lysosome IPR008979; IPR006101; IPR013812; IPR023232; IPR023230; IPR006102; IPR006104; IPR006103; IPR013781; IPR017853; Beta-glucuronidase (EC 3.2.1.31) GUSB Canis familiaris (Dog) (Canis lupus familiaris) TR37233_c4_g1_i1 Q06441 TSP4_XENLA 3.00E-108 GO:0005509; GO:0007155; GO:0031012; GO:0005615; GO:0051781; GO:0016529 calcium ion binding; cell adhesion; extracellular matrix; extracellular space; positive regulation of cell division; sarcoplasmic reticulum IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR018097; IPR023413; IPR009030; IPR001791; IPR024665; IPR003367; IPR017897; IPR008859; Thrombospondin-4 thbs4 tsp4 Xenopus laevis (African clawed frog) TR37234_c3_g1_i1 Q5R5T0 TRM1L_PONAB 7.00E-07 GO:0007610; GO:0046872; GO:0004809; GO:0000049 behavior; metal ion binding; tRNA (guanine-N2-)-methyltransferase activity; tRNA binding IPR002905; IPR007087; IPR015880; TRMT1-like protein (EC 2.1.1.-) TRMT1L Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37234_c3_g1_i2 A2RSY6 TRM1L_MOUSE 4.00E-06 GO:0008344; GO:0046872; GO:0004809; GO:0000049 adult locomotory behavior; metal ion binding; tRNA (guanine-N2-)-methyltransferase activity; tRNA binding IPR002905; IPR007087; IPR015880; TRMT1-like protein (EC 2.1.1.-) Trmt1l Mus musculus (Mouse) TR37234_c4_g1_i1 A6QLU6 GP133_BOVIN 6.00E-19 GO:0004930; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR008985; IPR013320; IPR017981; IPR000832; IPR017983; IPR000203; Probable G-protein coupled receptor 133 GPR133 Bos taurus (Bovine) TR37234_c4_g1_i2 Q58Y75 GP113_MOUSE 1.00E-12 GO:0004930; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR001879; IPR000832; IPR017983; IPR000203; Probable G-protein coupled receptor 113 (G-protein coupled receptor PGR23) Gpr113 Gm1041 Pcr113 Pgr23 Mus musculus (Mouse) TR37234_c6_g1_i1 O88923 LPHN2_RAT 3.00E-12 GO:0004930; GO:0007420; GO:0030246; GO:0016021; GO:0043005; GO:0007218; GO:0005886 G-protein coupled receptor activity; brain development; carbohydrate binding; integral to membrane; neuron projection; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR001879; IPR003924; IPR003334; IPR000832; IPR017983; IPR000203; IPR000922; IPR003112; Latrophilin-2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) Lphn2 Cirl2 Cl2 Rattus norvegicus (Rat) TR37234_c6_g1_i2 O88278 CELR3_RAT 1.00E-13 GO:0004930; GO:0007413; GO:0005509; GO:0042384; GO:0007156; GO:0016021; GO:0001764; GO:0007218; GO:0005886; GO:0032880 G-protein coupled receptor activity; axonal fasciculation; calcium ion binding; cilium assembly; homophilic cell adhesion; integral to membrane; neuron migration; neuropeptide signaling pathway; plasma membrane; regulation of protein localization IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR013032; IPR002049; IPR017981; IPR001879; IPR000832; IPR017983; IPR000203; IPR001791; Cadherin EGF LAG seven-pass G-type receptor 3 (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) Celsr3 Megf2 Rattus norvegicus (Rat) TR37234_c8_g1_i1 Q8IZF6 GP112_HUMAN 6.00E-08 GO:0004930; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR008985; IPR013320; IPR017981; IPR000832; IPR017983; IPR000203; IPR001759; Probable G-protein coupled receptor 112 GPR112 Homo sapiens (Human) TR37236_c0_g2_i1 P08059 G6PI_PIG 0 GO:0001525; GO:0005737; GO:0005615; GO:0006094; GO:0004347; GO:0006096 angiogenesis; cytoplasm; extracellular space; gluconeogenesis; glucose-6-phosphate isomerase activity; glycolysis IPR001672; IPR023096; IPR018189; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) GPI Sus scrofa (Pig) TR37236_c0_g2_i2 P77877 G6PI_KLEOX 3.00E-80 GO:0005737; GO:0006094; GO:0004347; GO:0006096 cytoplasm; gluconeogenesis; glucose-6-phosphate isomerase activity; glycolysis IPR001672; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Fragment) pgi Klebsiella oxytoca TR37238_c0_g1_i2 O15432 COPT2_HUMAN 8.00E-07 GO:0005375; GO:0005887 copper ion transmembrane transporter activity; integral to plasma membrane IPR007274; Probable low affinity copper uptake protein 2 (Copper transporter 2) (hCTR2) (Solute carrier family 31 member 2) SLC31A2 COPT2 CTR2 Homo sapiens (Human) TR37238_c0_g1_i3 Q5RAS6 COPT1_PONAB 4.00E-11 GO:0005375; GO:0016021; GO:0005886 copper ion transmembrane transporter activity; integral to membrane; plasma membrane IPR007274; High affinity copper uptake protein 1 (Copper transporter 1) (Solute carrier family 31 member 1) SLC31A1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37239_c1_g2_i1 Q5REX3 ZFR_PONAB 1.00E-59 GO:0003677; GO:0003723; GO:0005694; GO:0005737; GO:0007275; GO:0005634; GO:0008270 DNA binding; RNA binding; chromosome; cytoplasm; multicellular organismal development; nucleus; zinc ion binding IPR006561; IPR007087; IPR015880; IPR003604; Zinc finger RNA-binding protein ZFR Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37239_c1_g4_i1 Q5R6Y5 STRBP_PONAB 4.00E-101 GO:0003677; GO:0003723; GO:0030154; GO:0005737; GO:0007275; GO:0007283 DNA binding; RNA binding; cell differentiation; cytoplasm; multicellular organismal development; spermatogenesis IPR014720; IPR006561; Spermatid perinuclear RNA-binding protein STRBP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37239_c1_g4_i2 Q96KR1 ZFR_HUMAN 1.00E-120 GO:0003677; GO:0003723; GO:0005694; GO:0005737; GO:0007275; GO:0005634; GO:0008270 Q15796 DNA binding; RNA binding; chromosome; cytoplasm; multicellular organismal development; nucleus; zinc ion binding IPR006561; IPR007087; IPR015880; IPR003604; Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) ZFR Homo sapiens (Human) TR37240_c1_g1_i1 Q460N5 PAR14_HUMAN 5.00E-07 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR37240_c1_g1_i2 Q97UU4 Y2899_SULSO 2.00E-12 IPR002589; Uncharacterized protein SSO2899 SSO2899 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) TR37242_c4_g1_i1 Q8P5Z8 Y3184_XANCP 7.00E-06 IPR002589; Macro domain-containing protein XCC3184 XCC3184 Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568) TR37242_c4_g1_i2 D2TT52 YMDB_CITRI 5.00E-12 GO:0019213; GO:0060701; GO:0001883; GO:0042278; GO:0008428 deacetylase activity; negative regulation of ribonuclease activity; purine nucleoside binding; purine nucleoside metabolic process; ribonuclease inhibitor activity IPR002589; IPR024900; O-acetyl-ADP-ribose deacetylase (EC 3.5.1.-) (Regulator of RNase III activity) ymdB ROD_11041 Citrobacter rodentium (strain ICC168) (Citrobacter freundii biotype 4280) TR37242_c4_g1_i4 Q460N5 PAR14_HUMAN 2.00E-86 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR37242_c4_g1_i5 Q8Q0F9 Y177_METMA 8.00E-08 IPR002589; Macro domain-containing protein MM_0177 MM_0177 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR37242_c4_g1_i6 Q460N5 PAR14_HUMAN 8.00E-38 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR37243_c0_g1_i1 O46522 CY24B_BOVIN 0 GO:0009055; GO:0050660; GO:0020037; GO:0005887; GO:0046872; GO:0016491; GO:0042554; GO:0005244 electron carrier activity; flavin adenine dinucleotide binding; heme binding; integral to plasma membrane; metal ion binding; oxidoreductase activity; superoxide anion generation; voltage-gated ion channel activity IPR000778; IPR013112; IPR017927; IPR013130; IPR013121; IPR017938; Cytochrome b-245 heavy chain (EC 1.-.-.-) (CGD91-phox) (Cytochrome b(558) subunit beta) (Cytochrome b558 subunit beta) (Heme-binding membrane glycoprotein gp91phox) (Neutrophil cytochrome b 91 kDa polypeptide) (gp91-1) (gp91-phox) (p22 phagocyte B-cytochrome) CYBB Bos taurus (Bovine) TR37244_c1_g1_i3 Q86V88 MGDP1_HUMAN 5.00E-35 GO:0046872; GO:0035335; GO:0004725 metal ion binding; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR023214; IPR010033; IPR024734; IPR010036; Magnesium-dependent phosphatase 1 (MDP-1) (EC 3.1.3.-) (EC 3.1.3.48) MDP1 Homo sapiens (Human) TR37244_c1_g1_i4 Q86V88 MGDP1_HUMAN 6.00E-31 GO:0046872; GO:0035335; GO:0004725 metal ion binding; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR023214; IPR010033; IPR024734; IPR010036; Magnesium-dependent phosphatase 1 (MDP-1) (EC 3.1.3.-) (EC 3.1.3.48) MDP1 Homo sapiens (Human) TR37247_c2_g2_i1 Q8R344 CCD12_MOUSE 2.00E-35 IPR013169; Coiled-coil domain-containing protein 12 Ccdc12 Mus musculus (Mouse) TR37248_c0_g1_i1 Q5W9T5 OPR_OCTVU 2.00E-07 GO:0004930; GO:0016021; GO:0005886; GO:0005000 G-protein coupled receptor activity; integral to membrane; plasma membrane; vasopressin receptor activity IPR000276; IPR017452; IPR001817; Octopressin receptor OPR OTR Octopus vulgaris (Common octopus) TR37248_c0_g1_i3 Q63447 NPY4R_RAT 4.00E-06 GO:0016021; GO:0001602; GO:0001601; GO:0042277; GO:0005886 integral to membrane; pancreatic polypeptide receptor activity; peptide YY receptor activity; peptide binding; plasma membrane IPR000276; IPR017452; IPR001933; IPR000611; Neuropeptide Y receptor type 4 (NPY4-R) (Pancreatic polypeptide receptor 1) (PP1) Npy4r Ppyr1 Rattus norvegicus (Rat) TR37250_c1_g1_i1 Q14643 ITPR1_HUMAN 8.00E-36 GO:0038095; GO:0038096; GO:0007202; GO:0005955; GO:0032469; GO:0005789; GO:0006112; GO:0007173; GO:0008543; GO:0045087; GO:0005220; GO:0016021; GO:0005218; GO:0070059; GO:0048011; GO:0005637; GO:0005730; GO:0035091; GO:0030168; GO:0031088; GO:0031095; GO:0009791; GO:0014069; GO:0050796; GO:0051209; GO:0001666; GO:0016529; GO:0044281; GO:0050882 "Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; activation of phospholipase C activity; calcineurin complex; endoplasmic reticulum calcium ion homeostasis; endoplasmic reticulum membrane; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; integral to membrane; intracellular ligand-gated calcium channel activity; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; neurotrophin TRK receptor signaling pathway; nuclear inner membrane; nucleolus; phosphatidylinositol binding; platelet activation; platelet dense granule membrane; platelet dense tubular network membrane; post-embryonic development; postsynaptic density; regulation of insulin secretion; release of sequestered calcium ion into cytosol; response to hypoxia; sarcoplasmic reticulum; small molecule metabolic process; voluntary musculoskeletal movement" IPR016024; IPR000699; IPR014821; IPR000493; IPR005821; IPR016093; IPR013662; IPR015925; "Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)" ITPR1 INSP3R1 Homo sapiens (Human) TR37251_c0_g1_i1 Q3MHW9 NB5R1_BOVIN 2.00E-132 GO:0004128; GO:0016021; GO:0016126 "cytochrome-b5 reductase activity, acting on NAD(P)H; integral to membrane; sterol biosynthetic process" IPR017927; IPR001709; IPR001834; IPR008333; IPR001433; IPR017938; NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) CYB5R1 Bos taurus (Bovine) TR37251_c0_g1_i2 Q3MHW9 NB5R1_BOVIN 2.00E-132 GO:0004128; GO:0016021; GO:0016126 "cytochrome-b5 reductase activity, acting on NAD(P)H; integral to membrane; sterol biosynthetic process" IPR017927; IPR001709; IPR001834; IPR008333; IPR001433; IPR017938; NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) CYB5R1 Bos taurus (Bovine) TR37252_c0_g1_i3 P61859 CALM_NEUCR 1.00E-34 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) cmd-1 cmd1 94C8.160 NCU04120 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR37254_c2_g1_i1 Q8BIJ6 SYIM_MOUSE 0 GO:0005524; GO:0002161; GO:0004822; GO:0006428; GO:0005759; GO:0005739; GO:0006450 ATP binding; aminoacyl-tRNA editing activity; isoleucine-tRNA ligase activity; isoleucyl-tRNA aminoacylation; mitochondrial matrix; mitochondrion; regulation of translational fidelity IPR001412; IPR002300; IPR002301; IPR023585; IPR014729; IPR009080; IPR013155; IPR009008; IPR010663; "Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)" Iars2 Mus musculus (Mouse) TR37254_c2_g2_i1 Q94425 SYIM_CIOIN 8.00E-55 GO:0005524; GO:0002161; GO:0004822; GO:0006428; GO:0005759; GO:0006450 ATP binding; aminoacyl-tRNA editing activity; isoleucine-tRNA ligase activity; isoleucyl-tRNA aminoacylation; mitochondrial matrix; regulation of translational fidelity IPR002300; IPR002301; IPR023585; IPR014729; IPR009008; "Probable isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) (Fragment)" Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) TR37254_c2_g2_i2 Q5JGN7 SYV_PYRKO 9.00E-29 GO:0005524; GO:0002161; GO:0005737; GO:0006450; GO:0004832; GO:0006438 ATP binding; aminoacyl-tRNA editing activity; cytoplasm; regulation of translational fidelity; valine-tRNA ligase activity; valyl-tRNA aminoacylation IPR001412; IPR002300; IPR014729; IPR009080; IPR013155; IPR009008; IPR022874; IPR002303; Valine--tRNA ligase (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) valS TK1274 Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) TR37255_c0_g1_i1 Q5EA79 GALM_BOVIN 2.00E-60 GO:0004034; GO:0030246; GO:0005737; GO:0019318 aldose 1-epimerase activity; carbohydrate binding; cytoplasm; hexose metabolic process IPR018052; IPR015443; IPR008183; IPR011013; IPR014718; Carbohydrate metabolism; hexose metabolism. Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase) GALM Bos taurus (Bovine) TR37255_c0_g1_i2 P40801 GAL10_PACTA 7.00E-16 GO:0003978; GO:0004034; GO:0030246; GO:0044237; GO:0050662; GO:0006012 UDP-glucose 4-epimerase activity; aldose 1-epimerase activity; carbohydrate binding; cellular metabolic process; coenzyme binding; galactose metabolic process IPR018052; IPR008183; IPR025308; IPR001509; IPR011013; IPR005886; IPR014718; IPR016040; Carbohydrate metabolism; galactose metabolism. Carbohydrate metabolism; hexose metabolism. Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase); Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase)] GAL10 Pachysolen tannophilus (Yeast) TR37255_c0_g1_i5 P05149 GALM_ACICA 2.00E-59 GO:0004034; GO:0030246; GO:0019318; GO:0042597 aldose 1-epimerase activity; carbohydrate binding; hexose metabolic process; periplasmic space IPR018052; IPR015443; IPR008183; IPR011013; IPR014718; Carbohydrate metabolism; hexose metabolism. Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase) (Type-1 mutarotase) mro Acinetobacter calcoaceticus TR37256_c1_g3_i3 O54974 LEG7_MOUSE 3.00E-06 GO:0006915; GO:0030246; GO:0005737; GO:0005576; GO:0005634 apoptotic process; carbohydrate binding; cytoplasm; extracellular region; nucleus IPR008985; IPR013320; IPR001079; Galectin-7 (Gal-7) Lgals7 Mus musculus (Mouse) TR37259_c0_g2_i1 Q9H0C8 ILKAP_HUMAN 3.00E-133 GO:0005737; GO:0046872; GO:0045786; GO:0006470; GO:0004722 Q13418 cytoplasm; metal ion binding; negative regulation of cell cycle; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP) (EC 3.1.3.16) ILKAP Homo sapiens (Human) TR37259_c0_g2_i2 P49595 PP2C1_CAEEL 2.00E-19 GO:0046872; GO:0006470; GO:0004722 metal ion binding; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; Probable protein phosphatase 2C F42G9.1 (PP2C) (EC 3.1.3.16) F42G9.1 Caenorhabditis elegans TR37260_c1_g1_i2 A8KB59 CC153_DANRE 3.00E-13 Coiled-coil domain-containing protein 153 ccdc153 zgc:171582 Danio rerio (Zebrafish) (Brachydanio rerio) TR37260_c1_g1_i3 A8KB59 CC153_DANRE 8.00E-06 Coiled-coil domain-containing protein 153 ccdc153 zgc:171582 Danio rerio (Zebrafish) (Brachydanio rerio) TR37262_c1_g1_i2 Q9Y2Q3 GSTK1_HUMAN 6.00E-72 GO:0006749; GO:0004602; GO:0004364; GO:0005743; GO:0005759; GO:0005777; GO:0015035 glutathione metabolic process; glutathione peroxidase activity; glutathione transferase activity; mitochondrial inner membrane; mitochondrial matrix; peroxisome; protein disulfide oxidoreductase activity IPR001853; IPR014440; IPR012336; Glutathione S-transferase kappa 1 (EC 2.5.1.18) (GST 13-13) (GST class-kappa) (GSTK1-1) (hGSTK1) (Glutathione S-transferase subunit 13) GSTK1 HDCMD47P Homo sapiens (Human) TR37263_c0_g1_i1 P0C8L6 PHS_HYPDU 5.00E-44 GO:0008124; GO:0006729 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; tetrahydrobiopterin biosynthetic process IPR001533; Probable pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Pterin carbinolamine dehydratase) (PCD) Pcd Hypsibius dujardini (Water bear) (Macrobiotus dujardini) TR37263_c0_g1_i2 P58249 PHS_DROVI 4.00E-48 GO:0008124; GO:0006729 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; tetrahydrobiopterin biosynthetic process IPR001533; Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Pterin carbinolamine dehydratase) (PCD) Pcd Drosophila virilis (Fruit fly) TR37264_c0_g1_i1 Q8WZ42 TITIN_HUMAN 2.00E-19 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR37264_c0_g1_i2 Q8WZ42 TITIN_HUMAN 6.00E-19 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR37265_c0_g2_i4 Q5UR67 YR617_MIMIV 1.00E-19 IPR012816; Uncharacterized protein R617 MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) TR37266_c0_g1_i1 O54873 AIMP1_CRIGR 2.00E-35 GO:0005794; GO:0001525; GO:0006915; GO:0007155; GO:0005829; GO:0005783; GO:0005615; GO:0006006; GO:0006954; GO:0005634; GO:0000049; GO:0006412; GO:0030133 Golgi apparatus; angiogenesis; apoptotic process; cell adhesion; cytosol; endoplasmic reticulum; extracellular space; glucose metabolic process; inflammatory response; nucleus; tRNA binding; translation; transport vesicle IPR012340; IPR002547; Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Multisynthase complex auxiliary component p43) [Cleaved into: Endothelial monocyte-activating polypeptide 2 (EMAP-II) (Small inducible cytokine subfamily E member 1)] AIMP1 SCYE1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR37266_c0_g1_i2 Q5ZJ08 SYYC_CHICK 0 GO:0005524; GO:0005737; GO:0000049; GO:0004831; GO:0006437 ATP binding; cytoplasm; tRNA binding; tyrosine-tRNA ligase activity; tyrosyl-tRNA aminoacylation IPR002305; IPR012340; IPR014729; IPR002547; IPR002307; IPR023617; "Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)" YARS RCJMB04_21p3 Gallus gallus (Chicken) TR37267_c0_g1_i1 Q2F7Z7 TMM59_PIG 3.00E-35 GO:0000139; GO:0006914; GO:0004175; GO:0016021; GO:0005770; GO:0031902; GO:0005765; GO:0005764; GO:0005886; GO:0010508 Golgi membrane; autophagy; endopeptidase activity; integral to membrane; late endosome; late endosome membrane; lysosomal membrane; lysosome; plasma membrane; positive regulation of autophagy IPR022065; Transmembrane protein 59 TMEM59 Sus scrofa (Pig) TR37267_c0_g1_i5 Q2F7Z7 TMM59_PIG 3.00E-35 GO:0000139; GO:0006914; GO:0004175; GO:0016021; GO:0005770; GO:0031902; GO:0005765; GO:0005764; GO:0005886; GO:0010508 Golgi membrane; autophagy; endopeptidase activity; integral to membrane; late endosome; late endosome membrane; lysosomal membrane; lysosome; plasma membrane; positive regulation of autophagy IPR022065; Transmembrane protein 59 TMEM59 Sus scrofa (Pig) TR37267_c0_g1_i7 Q2F7Z7 TMM59_PIG 3.00E-35 GO:0000139; GO:0006914; GO:0004175; GO:0016021; GO:0005770; GO:0031902; GO:0005765; GO:0005764; GO:0005886; GO:0010508 Golgi membrane; autophagy; endopeptidase activity; integral to membrane; late endosome; late endosome membrane; lysosomal membrane; lysosome; plasma membrane; positive regulation of autophagy IPR022065; Transmembrane protein 59 TMEM59 Sus scrofa (Pig) TR37268_c0_g1_i1 Q7W977 ECTD_BORPA 9.00E-18 GO:0016725 "oxidoreductase activity, acting on CH or CH2 groups" IPR012774; IPR008775; Ectoine hydroxylase (EC 1.17.-.-) ectD BPP1891 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) TR37268_c0_g1_i2 Q6QUY7 ECTD_STRAQ 1.00E-12 GO:0016725 "oxidoreductase activity, acting on CH or CH2 groups" IPR012774; IPR008775; Ectoine hydroxylase (EC 1.17.-.-) ectD thpD Streptomyces anulatus (Streptomyces chrysomallus) TR37268_c0_g1_i5 Q5YW75 ECTD_NOCFA 8.00E-09 GO:0016725 "oxidoreductase activity, acting on CH or CH2 groups" IPR012774; IPR008775; Ectoine hydroxylase (EC 1.17.-.-) ectD NFA_27190 Nocardia farcinica (strain IFM 10152) TR37269_c3_g2_i2 Q14849 STAR3_HUMAN 6.00E-68 GO:0015485; GO:0008203; GO:0030301; GO:0017127; GO:0016021; GO:0031902; GO:0005765; GO:0006839; GO:0005739; GO:0006701 cholesterol binding; cholesterol metabolic process; cholesterol transport; cholesterol transporter activity; integral to membrane; late endosome membrane; lysosomal membrane; mitochondrial transport; mitochondrion; progesterone biosynthetic process IPR019498; IPR000799; IPR023393; IPR002913; StAR-related lipid transfer protein 3 (Metastatic lymph node gene 64 protein) (MLN 64) (Protein CAB1) (START domain-containing protein 3) (StARD3) STARD3 CAB1 MLN64 Homo sapiens (Human) TR37269_c3_g2_i4 O95772 MENTO_HUMAN 1.00E-30 GO:0016021; GO:0031902; GO:0005765 integral to membrane; late endosome membrane; lysosomal membrane IPR019498; MLN64 N-terminal domain homolog (STARD3 N-terminal-like protein) STARD3NL MENTHO UNQ855/PRO1864 Homo sapiens (Human) TR37269_c3_g2_i5 Q90ZB9 STAR3_SALFO 4.00E-31 GO:0015485; GO:0030301; GO:0017127; GO:0006694 cholesterol binding; cholesterol transport; cholesterol transporter activity; steroid biosynthetic process IPR019498; IPR000799; IPR023393; IPR002913; StAR-related lipid transfer protein 3 (MLN64-like protein) (START domain-containing protein 3) (StARD3) (Fragment) stard3 mln64 Salvelinus fontinalis (Brook trout) (Salmo fontinalis) TR37270_c3_g1_i1 C4YFX2 TUP1_CANAW 2.00E-10 GO:0006355; GO:0006351 "regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR020472; IPR001632; IPR013890; IPR015943; IPR001680; IPR019775; IPR017986; Transcriptional repressor TUP1 TUP1 CHP1 CAWG_01360 Candida albicans (strain WO-1) (Yeast) TR37270_c4_g1_i1 A0JP70 WDR90_XENTR 7.00E-93 IPR007714; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 90 wdr90 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37270_c4_g3_i1 Q5F201 WDR16_MOUSE 4.00E-15 GO:0005737; GO:0043231 cytoplasm; intracellular membrane-bounded organelle IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 16 Wdr16 Mus musculus (Mouse) TR37271_c0_g1_i1 Q7ZWX9 MIDNB_XENLA 1.00E-44 GO:0005730 nucleolus IPR000626; Midnolin-B (Midbrain nucleolar protein B) midn-b Xenopus laevis (African clawed frog) TR37272_c1_g1_i1 Q90WJ8 AJL2_ANGJA 7.00E-09 GO:0030246; GO:0050829; GO:0005576; GO:0043152 carbohydrate binding; defense response to Gram-negative bacterium; extracellular region; induction of bacterial agglutination IPR001304; IPR016186; IPR018378; IPR016187; Lactose-binding lectin l-2 (Ajl-2) l-2 Anguilla japonica (Japanese eel) TR37272_c1_g1_i2 P82596 PLC_HALLA 2.00E-19 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR37272_c3_g3_i1 Q8R1F9 RPP40_MOUSE 3.00E-33 GO:0005655; GO:0004526; GO:0001682 nucleolar ribonuclease P complex; ribonuclease P activity; tRNA 5'-leader removal IPR013893; Ribonuclease P protein subunit p40 (RNaseP protein p40) (EC 3.1.26.5) Rpp40 Mus musculus (Mouse) TR37273_c4_g1_i17 Q9Y6R7 FCGBP_HUMAN 2.00E-13 GO:0005737; GO:0005576 cytoplasm; extracellular region IPR003645; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) TR37273_c4_g1_i3 Q9Y6R7 FCGBP_HUMAN 3.00E-21 GO:0005737; GO:0005576 cytoplasm; extracellular region IPR003645; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) TR37273_c4_g1_i6 Q9Y6R7 FCGBP_HUMAN 7.00E-22 GO:0005737; GO:0005576 cytoplasm; extracellular region IPR003645; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) TR37274_c0_g2_i5 Q9Y2M2 CC032_HUMAN 4.00E-65 GO:0005737 cytoplasm Protein SSUH2 homolog (Protein ssu-2 homolog) SSUH2 C3orf32 FLS485 Homo sapiens (Human) TR37274_c0_g2_i6 Q9Y2M2 CC032_HUMAN 6.00E-56 GO:0005737 cytoplasm Protein SSUH2 homolog (Protein ssu-2 homolog) SSUH2 C3orf32 FLS485 Homo sapiens (Human) TR37276_c0_g2_i1 Q2KIL7 R3HD4_BOVIN 8.00E-42 GO:0003676; GO:0005634 nucleic acid binding; nucleus IPR025952; IPR001374; R3H domain-containing protein 4 R3HDM4 Bos taurus (Bovine) TR37277_c1_g1_i1 Q99PW4 PRPK_MOUSE 6.00E-71 GO:0005524; GO:0009103; GO:0016020; GO:0005634; GO:0018108; GO:0004674; GO:0004713 ATP binding; lipopolysaccharide biosynthetic process; membrane; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity IPR022495; IPR011009; IPR010440; IPR000719; IPR008266; TP53-regulating kinase (EC 2.7.11.1) (Atypical serine/threonine protein kinase Tp53rk) (EKC/KEOPS complex subunit Tp53rk) (EC 3.6.-.-) (Nori-2) (p53-related protein kinase) Tp53rk Prpk Trp53rk Mus musculus (Mouse) TR37277_c1_g1_i3 Q96S44 PRPK_HUMAN 7.00E-72 GO:0005524; GO:0009103; GO:0016020; GO:0005634; GO:0002039; GO:0018108; GO:0004674; GO:0004713 Q9Y3C4 ATP binding; lipopolysaccharide biosynthetic process; membrane; nucleus; p53 binding; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity IPR022495; IPR011009; IPR010440; IPR000719; IPR008266; TP53-regulating kinase (EC 2.7.11.1) (Atypical serine/threonine protein kinase TP53RK) (EKC/KEOPS complex subunit TP53RK) (EC 3.6.-.-) (Nori-2) (p53-related protein kinase) TP53RK C20orf64 PRPK Homo sapiens (Human) TR37277_c1_g1_i4 Q99PW4 PRPK_MOUSE 1.00E-72 GO:0005524; GO:0009103; GO:0016020; GO:0005634; GO:0018108; GO:0004674; GO:0004713 ATP binding; lipopolysaccharide biosynthetic process; membrane; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity IPR022495; IPR011009; IPR010440; IPR000719; IPR008266; TP53-regulating kinase (EC 2.7.11.1) (Atypical serine/threonine protein kinase Tp53rk) (EKC/KEOPS complex subunit Tp53rk) (EC 3.6.-.-) (Nori-2) (p53-related protein kinase) Tp53rk Prpk Trp53rk Mus musculus (Mouse) TR37277_c2_g1_i2 Q5ZKJ5 TM180_CHICK 6.00E-49 GO:0016021 integral to membrane IPR016196; Transmembrane protein 180 TMEM180 RCJMB04_10g6 Gallus gallus (Chicken) TR37278_c0_g2_i10 Q9ER71 RHOJ_MOUSE 2.00E-06 GO:0005525; GO:0003924; GO:0007266; GO:0030036; GO:0005622; GO:0005886; GO:0008360; GO:0061299 GTP binding; GTPase activity; Rho protein signal transduction; actin cytoskeleton organization; intracellular; plasma membrane; regulation of cell shape; retina vasculature morphogenesis in camera-type eye IPR027417; IPR005225; IPR001806; IPR003578; Rho-related GTP-binding protein RhoJ (Tc10-like GTP-binding protein) Rhoj Arhj Rhoi Rhot Tc10l Tcl Mus musculus (Mouse) TR37278_c0_g2_i2 Q16YG0 CDC42_AEDAE 2.00E-51 GO:0005525; GO:0005912; GO:0005622; GO:0045185; GO:0007275; GO:0005886; GO:0045860; GO:0007264 GTP binding; adherens junction; intracellular; maintenance of protein location; multicellular organismal development; plasma membrane; positive regulation of protein kinase activity; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Cdc42 homolog Cdc42 AAEL008543 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR37278_c0_g2_i5 P79735 RAN_DANRE 2.00E-10 GO:0005525; GO:0003924; GO:0006886; GO:0006913; GO:0005634; GO:0007264 GTP binding; GTPase activity; intracellular protein transport; nucleocytoplasmic transport; nucleus; small GTPase mediated signal transduction IPR027417; IPR002041; IPR005225; IPR001806; GTP-binding nuclear protein Ran (GTPase Ran) (Ras-related nuclear protein) ran Danio rerio (Zebrafish) (Brachydanio rerio) TR37278_c0_g2_i7 P28186 RAE1C_ARATH 4.00E-13 GO:0005525; GO:0000139; GO:0009873; GO:0005886; GO:0015031; GO:0007264; GO:0005774 GTP binding; Golgi membrane; ethylene mediated signaling pathway; plasma membrane; protein transport; small GTPase mediated signal transduction; vacuolar membrane IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein RABE1c (AtRABE1c) (Ras-related protein Ara-3) (Ras-related protein Rab8A) (AtRab8A) RABE1C ARA-3 RAB8A At3g46060 F12M12.30 Arabidopsis thaliana (Mouse-ear cress) TR37278_c0_g2_i8 P84095 RHOG_HUMAN 5.00E-45 GO:0005525; GO:0003924; GO:0016601; GO:0007266; GO:0030036; GO:0032863; GO:0007411; GO:0060326; GO:0005829; GO:0005886; GO:0030168; GO:0008284; GO:0090004; GO:0045893 Q92556 "GTP binding; GTPase activity; Rac protein signal transduction; Rho protein signal transduction; actin cytoskeleton organization; activation of Rac GTPase activity; axon guidance; cell chemotaxis; cytosol; plasma membrane; platelet activation; positive regulation of cell proliferation; positive regulation of establishment of protein localization to plasma membrane; positive regulation of transcription, DNA-dependent" IPR027417; IPR005225; IPR001806; IPR003578; Rho-related GTP-binding protein RhoG RHOG ARHG Homo sapiens (Human) TR37278_c0_g2_i9 P34149 RACC_DICDI 6.00E-42 GO:0005525; GO:0031252; GO:0016477; GO:0006935; GO:0045184; GO:0005622; GO:0014065; GO:0005886; GO:0030838; GO:0019904; GO:0007264 GTP binding; cell leading edge; cell migration; chemotaxis; establishment of protein localization; intracellular; phosphatidylinositol 3-kinase cascade; plasma membrane; positive regulation of actin filament polymerization; protein domain specific binding; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Rho-related protein racC racC DDB_G0293526 Dictyostelium discoideum (Slime mold) TR37280_c4_g2_i1 P98068 SPAN_STRPU 2.00E-16 GO:0004222; GO:0007275; GO:0006508; GO:0008270 metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR000859; IPR000742; IPR013032; IPR024079; IPR001506; IPR006026; IPR017369; Protein SpAN (EC 3.4.24.-) SPAN Strongylocentrotus purpuratus (Purple sea urchin) TR37280_c4_g2_i10 Q9QZT0 CUZD1_RAT 3.00E-13 GO:0007565; GO:0009755; GO:0016021; GO:0030658; GO:0032023; GO:0042589 female pregnancy; hormone-mediated signaling pathway; integral to membrane; transport vesicle membrane; trypsinogen activation; zymogen granule membrane IPR000859; IPR001507; CUB and zona pellucida-like domain-containing protein 1 (CUB and ZP domain-containing protein 1) (Estrogen-regulated protein 1) (Uterus/ovary-specific protein 44) Cuzd1 Erg1 Rattus norvegicus (Rat) TR37280_c4_g2_i3 Q9BY79 MFRP_HUMAN 3.00E-12 GO:0009790; GO:0016021 embryo development; integral to membrane IPR000859; IPR020067; IPR023415; IPR002172; Membrane frizzled-related protein (Membrane-type frizzled-related protein) MFRP Homo sapiens (Human) TR37280_c4_g2_i4 O70244 CUBN_RAT 4.00E-38 GO:0031526; GO:0005509; GO:0008203; GO:0031419; GO:0030666; GO:0010008; GO:0030492; GO:0020028; GO:0042802; GO:0001701; GO:0043202; GO:0005765; GO:0043234; GO:0070207; GO:0004872; GO:0006898; GO:0007584; GO:0006766 Itself brush border membrane; calcium ion binding; cholesterol metabolic process; cobalamin binding; endocytic vesicle membrane; endosome membrane; hemoglobin binding; hemoglobin import; identical protein binding; in utero embryonic development; lysosomal lumen; lysosomal membrane; protein complex; protein homotrimerization; receptor activity; receptor-mediated endocytosis; response to nutrient; vitamin metabolic process IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; Cubilin (460 kDa receptor) (Glycoprotein 280) (gp280) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) Cubn Ifcr Rattus norvegicus (Rat) TR37280_c4_g2_i6 Q96PZ7 CSMD1_HUMAN 4.00E-14 GO:0016021 integral to membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 1 (CUB and sushi multiple domains protein 1) CSMD1 KIAA1890 UNQ5952/PRO19863 Homo sapiens (Human) TR37280_c4_g2_i8 Q0IIH7 ST14_BOVIN 6.00E-10 GO:0016021; GO:0006508; GO:0004252 integral to membrane; proteolysis; serine-type endopeptidase activity IPR000859; IPR023415; IPR002172; IPR001254; IPR018114; IPR017051; IPR000082; IPR009003; Suppressor of tumorigenicity 14 protein homolog (EC 3.4.21.109) (Serine protease 14) ST14 PRSS14 Bos taurus (Bovine) TR37280_c4_g2_i9 P42674 BP10_PARLI 1.00E-18 GO:0005938; GO:0005615; GO:0004222; GO:0048471; GO:0006508; GO:0008270 cell cortex; extracellular space; metalloendopeptidase activity; perinuclear region of cytoplasm; proteolysis; zinc ion binding IPR000859; IPR000742; IPR013032; IPR024079; IPR001506; IPR006026; IPR017369; Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) TR37280_c4_g5_i1 Q9Y6L7 TLL2_HUMAN 6.00E-10 GO:0005509; GO:0030154; GO:0030198; GO:0005576; GO:0004222; GO:0007275; GO:0006508; GO:0008270 calcium ion binding; cell differentiation; extracellular matrix organization; extracellular region; metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Tolloid-like protein 2 (EC 3.4.24.-) TLL2 KIAA0932 Homo sapiens (Human) TR37280_c4_g5_i2 Q5RDI1 PAMR1_PONAB 3.00E-11 GO:0003824; GO:0005576; GO:0008152 catalytic activity; extracellular region; metabolic process IPR000859; IPR000742; IPR013032; IPR001254; IPR001314; IPR000436; IPR009003; Inactive serine protease PAMR1 (Peptidase domain-containing protein associated with muscle regeneration 1) (Regeneration-associated muscle protease homolog) PAMR1 RAMP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37281_c0_g1_i1 P79148 ADRB1_CANFA 3.00E-10 GO:0005088; GO:0071880; GO:0004940; GO:0005769; GO:0016021; GO:0005886; GO:0032320; GO:0030819; GO:0043950; GO:0045823; GO:0005057 Ras guanyl-nucleotide exchange factor activity; adenylate cyclase-activating adrenergic receptor signaling pathway; beta1-adrenergic receptor activity; early endosome; integral to membrane; plasma membrane; positive regulation of Ras GTPase activity; positive regulation of cAMP biosynthetic process; positive regulation of cAMP-mediated signaling; positive regulation of heart contraction; receptor signaling protein activity IPR002233; IPR000507; IPR000276; IPR017452; Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) ADRB1 Canis familiaris (Dog) (Canis lupus familiaris) TR37281_c0_g1_i2 P29274 AA2AR_HUMAN 2.00E-10 GO:0001609; GO:0007190; GO:0006915; GO:0048143; GO:0032279; GO:0030673; GO:0008015; GO:0007596; GO:0006171; GO:0007267; GO:0006968; GO:0007417; GO:0030425; GO:0042755; GO:0012505; GO:0006954; GO:0005887; GO:0007626; GO:0046636; GO:0008285; GO:0043154; GO:0050728; GO:0040013; GO:0043524; GO:0006469; GO:0043116; GO:0048812; GO:0043025; GO:0048011; GO:0006909; GO:0014057; GO:0010579; GO:2001235; GO:0014049; GO:0050714; GO:0035815; GO:0032230; GO:0051968; GO:0035810; GO:0014069; GO:0045211; GO:0060134; GO:0048786; GO:0042734; GO:0007205; GO:0051924; GO:0060079; GO:0060080; GO:0051881; GO:0014061; GO:0048167; GO:0006355; GO:0001975; GO:0031000; GO:0042493; GO:0007600; GO:0007271; GO:0001963; GO:0035249; GO:0042311 Itself; P30542; P62158; Q99418; P14416; P31424-1; Q7Z6G3; Q13107 "G-protein coupled adenosine receptor activity; activation of adenylate cyclase activity; apoptotic process; astrocyte activation; asymmetric synapse; axolemma; blood circulation; blood coagulation; cAMP biosynthetic process; cell-cell signaling; cellular defense response; central nervous system development; dendrite; eating behavior; endomembrane system; inflammatory response; integral to plasma membrane; locomotory behavior; negative regulation of alpha-beta T cell activation; negative regulation of cell proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of inflammatory response; negative regulation of locomotion; negative regulation of neuron apoptotic process; negative regulation of protein kinase activity; negative regulation of vascular permeability; neuron projection morphogenesis; neuronal cell body; neurotrophin TRK receptor signaling pathway; phagocytosis; positive regulation of acetylcholine secretion, neurotransmission; positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway; positive regulation of apoptotic signaling pathway; positive regulation of glutamate secretion; positive regulation of protein secretion; positive regulation of renal sodium excretion; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; positive regulation of urine volume; postsynaptic density; postsynaptic membrane; prepulse inhibition; presynaptic active zone; presynaptic membrane; protein kinase C-activating G-protein coupled receptor signaling pathway; regulation of calcium ion transport; regulation of excitatory postsynaptic membrane potential; regulation of inhibitory postsynaptic membrane potential; regulation of mitochondrial membrane potential; regulation of norepinephrine secretion; regulation of synaptic plasticity; regulation of transcription, DNA-dependent; response to amphetamine; response to caffeine; response to drug; sensory perception; synaptic transmission, cholinergic; synaptic transmission, dopaminergic; synaptic transmission, glutamatergic; vasodilation" IPR001513; IPR001634; IPR000276; IPR017452; Adenosine receptor A2a ADORA2A ADORA2 Homo sapiens (Human) TR37281_c0_g1_i3 P61752 HRH2_PONPY 9.00E-10 GO:0001696; GO:0004969; GO:0016021; GO:0005886; GO:0045907 gastric acid secretion; histamine receptor activity; integral to membrane; plasma membrane; positive regulation of vasoconstriction IPR000276; IPR017452; IPR000503; Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I) HRH2 Pongo pygmaeus (Bornean orangutan) TR37281_c0_g1_i4 Q28558 MTR1L_SHEEP 6.00E-08 GO:0016021; GO:0008502; GO:0005886 integral to membrane; melatonin receptor activity; plasma membrane IPR000276; IPR017452; IPR002280; IPR000025; Melatonin-related receptor (G protein-coupled receptor 50) (H9) GPR50 Ovis aries (Sheep) TR37281_c0_g1_i5 P18825 ADA2C_HUMAN 6.00E-08 GO:0071883; GO:0032148; GO:0004938; GO:0043679; GO:0007267; GO:0005768; GO:0006112; GO:0035625; GO:0051379; GO:0007565; GO:0005887; GO:0032811; GO:0010700; GO:0070473; GO:0030168; GO:0045666; GO:0045907; GO:0042803; GO:0050796; GO:0051930; GO:0044281 activation of MAPK activity by adrenergic receptor signaling pathway; activation of protein kinase B activity; alpha2-adrenergic receptor activity; axon terminus; cell-cell signaling; endosome; energy reserve metabolic process; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway; epinephrine binding; female pregnancy; integral to plasma membrane; negative regulation of epinephrine secretion; negative regulation of norepinephrine secretion; negative regulation of uterine smooth muscle contraction; platelet activation; positive regulation of neuron differentiation; positive regulation of vasoconstriction; protein homodimerization activity; regulation of insulin secretion; regulation of sensory perception of pain; small molecule metabolic process IPR002233; IPR000735; IPR000276; IPR017452; Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR) ADRA2C ADRA2L2 ADRA2RL2 Homo sapiens (Human) TR37281_c0_g1_i6 Q5QD29 TAAR1_PANTR 4.00E-14 GO:0016021; GO:0005886; GO:0001594 integral to membrane; plasma membrane; trace-amine receptor activity IPR000276; IPR017452; IPR009133; IPR009132; Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1) TAAR1 TRAR1 Pan troglodytes (Chimpanzee) TR37282_c0_g1_i1 Q9DE27 RUVB2_XENLA 0 GO:0005524; GO:0043141; GO:0032508; GO:0006310; GO:0006281; GO:0071339; GO:0006355; GO:0006351 "ATP binding; ATP-dependent 5'-3' DNA helicase activity; DNA duplex unwinding; DNA recombination; DNA repair; MLL1 complex; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003593; IPR027417; IPR027238; IPR010339; RuvB-like 2 (EC 3.6.4.12) (Reptin) ruvbl2 Xenopus laevis (African clawed frog) TR37284_c5_g1_i1 O95544 NADK_HUMAN 2.00E-127 GO:0005524; GO:0046034; GO:0019674; GO:0003951; GO:0006741; GO:0005829; GO:0046872; GO:0006767 ATP binding; ATP metabolic process; NAD metabolic process; NAD+ kinase activity; NADP biosynthetic process; cytosol; metal ion binding; water-soluble vitamin metabolic process IPR017438; IPR016064; IPR017437; IPR002504; NAD kinase (EC 2.7.1.23) (Poly(P)/ATP NAD kinase) NADK Homo sapiens (Human) TR37285_c0_g1_i1 Q07536 MMSA_BOVIN 2.00E-129 GO:0000062; GO:0018478; GO:0004491; GO:0005739; GO:0019859; GO:0006573 fatty-acyl-CoA binding; malonate-semialdehyde dehydrogenase (acetylating) activity; methylmalonate-semialdehyde dehydrogenase (acylating) activity; mitochondrion; thymine metabolic process; valine metabolic process IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR010061; "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (Malonate-semialdehyde dehydrogenase [acylating]) (EC 1.2.1.18) (EC 1.2.1.27) (Aldehyde dehydrogenase family 6 member A1)" ALDH6A1 MMSDH Bos taurus (Bovine) TR37285_c0_g1_i2 Q9EQ20 MMSA_MOUSE 2.00E-169 GO:0050873; GO:0018478; GO:0004491; GO:0005739 brown fat cell differentiation; malonate-semialdehyde dehydrogenase (acetylating) activity; methylmalonate-semialdehyde dehydrogenase (acylating) activity; mitochondrion IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR010061; "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (Malonate-semialdehyde dehydrogenase [acylating]) (EC 1.2.1.18) (EC 1.2.1.27) (Aldehyde dehydrogenase family 6 member A1)" Aldh6a1 Mus musculus (Mouse) TR37285_c0_g2_i1 P42236 ALDH1_BACSU 3.00E-36 GO:0004029; GO:0006068 aldehyde dehydrogenase (NAD) activity; ethanol catabolic process IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. Probable aldehyde dehydrogenase YcbD (EC 1.2.1.3) ycbD BSU02470 Bacillus subtilis (strain 168) TR37285_c0_g2_i2 P55653 GABD_RHISN 5.00E-25 GO:0009450; GO:0009013 gamma-aminobutyric acid catabolic process; succinate-semialdehyde dehydrogenase [NAD(P)+] activity IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR010102; Amino-acid degradation; 4-aminobutanoate degradation. Probable succinate-semialdehyde dehydrogenase [NADP(+)] (SSDH) (EC 1.2.1.79) gabD NGR_a01630 y4sJ Rhizobium sp. (strain NGR234) TR37286_c1_g1_i2 O96790 DPGN_DIPMA 2.00E-28 GO:0005576; GO:0050819; GO:0004867 extracellular region; negative regulation of coagulation; serine-type endopeptidase inhibitor activity IPR002350; Serine protease inhibitor dipetalogastin (Dipetalin) (Fragment) Dipetalogaster maximus (Blood-sucking bug) TR37286_c1_g1_i3 P08479 IPSG_VULVU 5.00E-07 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002350; IPR001239; "Double-headed protease inhibitor, submandibular gland" Vulpes vulpes (Red fox) TR37286_c1_g1_i4 O96790 DPGN_DIPMA 1.00E-29 GO:0005576; GO:0050819; GO:0004867 extracellular region; negative regulation of coagulation; serine-type endopeptidase inhibitor activity IPR002350; Serine protease inhibitor dipetalogastin (Dipetalin) (Fragment) Dipetalogaster maximus (Blood-sucking bug) TR37286_c1_g1_i5 P08480 IPSG_FELCA 8.00E-09 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002350; IPR001239; "Double-headed protease inhibitor, submandibular gland" Felis catus (Cat) (Felis silvestris catus) TR37286_c1_g2_i1 P01005 IOVO_CHICK 1.00E-14 GO:0019863; GO:0019864; GO:0005576; GO:0043234; GO:0004867 IgE binding; IgG binding; extracellular region; protein complex; serine-type endopeptidase inhibitor activity IPR002350; Ovomucoid (Allergen Gal d I) (allergen Gal d 1) Gallus gallus (Chicken) TR37286_c1_g2_i2 Q9UIK5 TEFF2_HUMAN 1.00E-06 GO:0005576; GO:0016021 extracellular region; integral to membrane IPR000742; IPR013032; IPR002350; Tomoregulin-2 (TR-2) (Hyperplastic polyposis protein 1) (Transmembrane protein with EGF-like and two follistatin-like domains) TMEFF2 HPP1 TENB2 TPEF UNQ178/PRO204 Homo sapiens (Human) TR37286_c1_g2_i4 O95980 RECK_HUMAN 2.00E-07 GO:0031225; GO:0001955; GO:0007566; GO:0030198; GO:0016020; GO:0008191; GO:0005886; GO:0004867 P04626 anchored to membrane; blood vessel maturation; embryo implantation; extracellular matrix organization; membrane; metalloendopeptidase inhibitor activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR002350; Reversion-inducing cysteine-rich protein with Kazal motifs (hRECK) (Suppressor of tumorigenicity 15 protein) RECK ST15 Homo sapiens (Human) TR37286_c1_g2_i6 P86987 IMSP6_VENPH 8.00E-12 GO:0005576 extracellular region IPR002350; Insoluble matrix shell protein 6 (IMSP6) Venerupis philippinarum (Japanese littleneck clam) (Tapes japonica) TR37286_c1_g2_i7 Q06684 THBI_RHOPR 5.00E-10 GO:0007596; GO:0005576; GO:0004867 blood coagulation; extracellular region; serine-type endopeptidase inhibitor activity IPR002350; Thrombin inhibitor rhodniin Rhodnius prolixus (Triatomid bug) TR37288_c0_g1_i2 Q8VDI9 ALG9_MOUSE 0 GO:0052926; GO:0052918; GO:0005789; GO:0016021; GO:0006486 "dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity; dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity; endoplasmic reticulum membrane; integral to membrane; protein glycosylation" IPR005599; Protein modification; protein glycosylation. "Alpha-1,2-mannosyltransferase ALG9 (EC 2.4.1.259) (EC 2.4.1.261) (Asparagine-linked glycosylation protein 9 homolog) (Disrupted in bipolar disorder protein 1 homolog) (Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) (Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase)" Alg9 Dibd1 Mus musculus (Mouse) TR37288_c0_g1_i3 Q8VDI9 ALG9_MOUSE 6.00E-95 GO:0052926; GO:0052918; GO:0005789; GO:0016021; GO:0006486 "dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity; dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity; endoplasmic reticulum membrane; integral to membrane; protein glycosylation" IPR005599; Protein modification; protein glycosylation. "Alpha-1,2-mannosyltransferase ALG9 (EC 2.4.1.259) (EC 2.4.1.261) (Asparagine-linked glycosylation protein 9 homolog) (Disrupted in bipolar disorder protein 1 homolog) (Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) (Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase)" Alg9 Dibd1 Mus musculus (Mouse) TR37289_c1_g1_i2 Q8CG85 MAMC2_MOUSE 7.00E-32 GO:0005783; GO:0005539; GO:0005614; GO:0016020; GO:0019800 endoplasmic reticulum; glycosaminoglycan binding; interstitial matrix; membrane; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IPR008985; IPR000998; MAM domain-containing protein 2 (MAM domain-containing proteoglycan) (Mamcan) Mamdc2 Mus musculus (Mouse) TR37289_c1_g1_i4 Q9Y493 ZAN_HUMAN 7.00E-15 GO:0007339; GO:0016337; GO:0016021; GO:0005886 binding of sperm to zona pellucida; cell-cell adhesion; integral to membrane; plasma membrane IPR008985; IPR000742; IPR013032; IPR000998; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; Zonadhesin ZAN Homo sapiens (Human) TR37289_c1_g1_i5 Q0WYX8 MDGA1_CHICK 1.00E-22 GO:0046658; GO:0001764 anchored to plasma membrane; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 MDGA1 Gallus gallus (Chicken) TR37289_c1_g1_i6 Q91641 THIB_XENLA 2.00E-30 GO:0005615; GO:0016020; GO:0007275 extracellular space; membrane; multicellular organismal development IPR008985; IPR000998; Thyroid hormone-induced protein B Xenopus laevis (African clawed frog) TR37289_c1_g1_i7 Q8NFP4 MDGA1_HUMAN 1.00E-22 GO:0046658; GO:0007420; GO:0001764; GO:0021527 anchored to plasma membrane; brain development; neuron migration; spinal cord association neuron differentiation IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3) MDGA1 MAMDC3 Homo sapiens (Human) TR37290_c0_g1_i2 Q8N2E2 VWDE_HUMAN 3.00E-07 GO:0005576 extracellular region IPR000742; IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) TR37293_c0_g1_i1 Q7TPD3 ROBO2_MOUSE 2.00E-12 GO:0030673; GO:0016199; GO:0009986; GO:0007156; GO:0042802; GO:0016021; GO:0001656; GO:0021891; GO:0050772; GO:0031290; GO:0001657 axolemma; axon midline choice point recognition; cell surface; homophilic cell adhesion; identical protein binding; integral to membrane; metanephros development; olfactory bulb interneuron development; positive regulation of axonogenesis; retinal ganglion cell axon guidance; ureteric bud development IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; Roundabout homolog 2 Robo2 Kiaa1568 Mus musculus (Mouse) TR37293_c0_g1_i2 O01761 UNC89_CAEEL 5.00E-09 GO:0005524; GO:0031430; GO:0005089; GO:0005543; GO:0004672; GO:0035023; GO:0030241 ATP binding; M band; Rho guanyl-nucleotide exchange factor activity; phospholipid binding; protein kinase activity; regulation of Rho protein signal transduction; skeletal muscle myosin thick filament assembly IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR007850; IPR001452; Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans TR37293_c0_g1_i3 Q7TPD3 ROBO2_MOUSE 5.00E-13 GO:0030673; GO:0016199; GO:0009986; GO:0007156; GO:0042802; GO:0016021; GO:0001656; GO:0021891; GO:0050772; GO:0031290; GO:0001657 axolemma; axon midline choice point recognition; cell surface; homophilic cell adhesion; identical protein binding; integral to membrane; metanephros development; olfactory bulb interneuron development; positive regulation of axonogenesis; retinal ganglion cell axon guidance; ureteric bud development IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; Roundabout homolog 2 Robo2 Kiaa1568 Mus musculus (Mouse) TR37294_c0_g1_i1 Q5ZK17 SETD6_CHICK 6.00E-104 GO:0032088; GO:0005634; GO:0018026; GO:0016279; GO:0050727 negative regulation of NF-kappaB transcription factor activity; nucleus; peptidyl-lysine monomethylation; protein-lysine N-methyltransferase activity; regulation of inflammatory response IPR011383; IPR015353; IPR001214; N-lysine methyltransferase SETD6 (EC 2.1.1.-) (SET domain-containing protein 6) SETD6 RCJMB04_13m6 Gallus gallus (Chicken) TR37295_c0_g1_i2 Q9ZT29 SC5D_TOBAC 5.00E-29 GO:0005789; GO:0006633; GO:0016021; GO:0005506; GO:0050046; GO:0016126 endoplasmic reticulum membrane; fatty acid biosynthetic process; integral to membrane; iron ion binding; lathosterol oxidase activity; sterol biosynthetic process IPR006694; Delta(7)-sterol-C5(6)-desaturase (EC 1.14.21.6) (Delta(7)-sterol-C5-desaturase) (Delta-7-C-5 sterol desaturase) Nicotiana tabacum (Common tobacco) TR37295_c0_g1_i3 O88822 SC5D_MOUSE 1.00E-129 GO:0005789; GO:0006633; GO:0016021; GO:0005506; GO:0050046; GO:0016126 endoplasmic reticulum membrane; fatty acid biosynthetic process; integral to membrane; iron ion binding; lathosterol oxidase activity; sterol biosynthetic process IPR006694; Lathosterol oxidase (EC 1.14.21.6) (C-5 sterol desaturase) (Delta(7)-sterol 5-desaturase) (Lathosterol 5-desaturase) (Sterol-C5-desaturase) Sc5d Sc5dl Mus musculus (Mouse) TR37297_c0_g1_i1 Q08B12 CTU2A_XENLA 5.00E-108 GO:0005829; GO:0000049; GO:0034227; GO:0002098 cytosol; tRNA binding; tRNA thio-modification; tRNA wobble uridine modification IPR014729; IPR019407; tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. Cytoplasmic tRNA 2-thiolation protein 2-A ctu2-a ncs2-a Xenopus laevis (African clawed frog) TR37298_c6_g1_i1 Q9R069 BCAM_MOUSE 2.00E-06 GO:0007155; GO:0009986; GO:0007160; GO:0005887; GO:0005055 cell adhesion; cell surface; cell-matrix adhesion; integral to plasma membrane; laminin receptor activity IPR013162; IPR007110; IPR013783; IPR003599; IPR003598; Basal cell adhesion molecule (B-CAM cell surface glycoprotein) (Lutheran antigen) (CD antigen CD239) Bcam Gplu Lu Mus musculus (Mouse) TR37298_c6_g1_i2 Q9R069 BCAM_MOUSE 2.00E-06 GO:0007155; GO:0009986; GO:0007160; GO:0005887; GO:0005055 cell adhesion; cell surface; cell-matrix adhesion; integral to plasma membrane; laminin receptor activity IPR013162; IPR007110; IPR013783; IPR003599; IPR003598; Basal cell adhesion molecule (B-CAM cell surface glycoprotein) (Lutheran antigen) (CD antigen CD239) Bcam Gplu Lu Mus musculus (Mouse) TR37299_c1_g2_i1 Q96RT7 GCP6_HUMAN 7.00E-41 GO:0000086; GO:0005813; GO:0005829; GO:0008274; GO:0005874; GO:0008017; GO:0007020; GO:0000922 G2/M transition of mitotic cell cycle; centrosome; cytosol; gamma-tubulin ring complex; microtubule; microtubule binding; microtubule nucleation; spindle pole IPR007259; Gamma-tubulin complex component 6 (GCP-6) TUBGCP6 GCP6 KIAA1669 Homo sapiens (Human) TR37299_c3_g1_i1 Q96RT7 GCP6_HUMAN 4.00E-111 GO:0000086; GO:0005813; GO:0005829; GO:0008274; GO:0005874; GO:0008017; GO:0007020; GO:0000922 G2/M transition of mitotic cell cycle; centrosome; cytosol; gamma-tubulin ring complex; microtubule; microtubule binding; microtubule nucleation; spindle pole IPR007259; Gamma-tubulin complex component 6 (GCP-6) TUBGCP6 GCP6 KIAA1669 Homo sapiens (Human) TR37300_c0_g1_i1 Q86U38 NOP9_HUMAN 7.00E-52 GO:0003723 RNA binding IPR011989; IPR016024; IPR001313; Nucleolar protein 9 NOP9 C14orf21 KIAA2021 Homo sapiens (Human) TR37300_c0_g1_i2 Q6BRH3 NOP9_DEBHA 3.00E-08 GO:0003723; GO:0005730; GO:0006364 RNA binding; nucleolus; rRNA processing IPR011989; IPR016024; IPR001313; Nucleolar protein 9 (Pumilio domain-containing protein NOP9) NOP9 DEHA2D16368g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR37301_c0_g1_i1 Q6P963 GLO2_DANRE 6.00E-57 GO:0006750; GO:0004416; GO:0005759; GO:0008270 glutathione biosynthetic process; hydroxyacylglutathione hydrolase activity; mitochondrial matrix; zinc ion binding IPR001279; IPR017782; "Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II)" hagh zgc:73161 Danio rerio (Zebrafish) (Brachydanio rerio) TR37301_c0_g1_i4 Q0VBY3 HAGHL_BOVIN 2.00E-28 GO:0006750; GO:0004416; GO:0008270 glutathione biosynthetic process; hydroxyacylglutathione hydrolase activity; zinc ion binding IPR001279; IPR017782; Hydroxyacylglutathione hydrolase-like protein (EC 3.1.2.-) HAGHL Bos taurus (Bovine) TR37301_c0_g2_i1 B4F6K2 GLO2_XENTR 1.00E-59 GO:0006750; GO:0004416; GO:0005759; GO:0008270 glutathione biosynthetic process; hydroxyacylglutathione hydrolase activity; mitochondrial matrix; zinc ion binding IPR001279; IPR017782; "Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II)" hagh Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37302_c1_g1_i1 F1QH17 MCA3A_DANRE 5.00E-117 GO:0071949; GO:0003779; GO:0030042; GO:0005737; GO:0005856; GO:0006887; GO:0016709; GO:0008270 "FAD binding; actin binding; actin filament depolymerization; cytoplasm; cytoskeleton; exocytosis; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; zinc ion binding" IPR001715; IPR022735; IPR002938; IPR003042; IPR001781; Protein-methionine sulfoxide oxidase mical3a (EC 1.14.13.-) (Molecule interacting with CasL protein 3A) (MICAL-3A) mical3a si:dkeyp-122e2.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR37304_c1_g1_i1 Q96AX1 VP33A_HUMAN 4.00E-168 GO:0005769; GO:0005770; GO:0031902; GO:0005765; GO:0032418; GO:0032400; GO:0048471; GO:0030220; GO:0015031; GO:0048070; GO:0006904; GO:0016192 early endosome; late endosome; late endosome membrane; lysosomal membrane; lysosome localization; melanosome localization; perinuclear region of cytoplasm; platelet formation; protein transport; regulation of developmental pigmentation; vesicle docking involved in exocytosis; vesicle-mediated transport IPR027482; IPR001619; IPR027121; Vacuolar protein sorting-associated protein 33A (hVPS33A) VPS33A Homo sapiens (Human) TR37308_c7_g1_i1 Q5HZT0 DOM3Z_XENLA 5.00E-37 GO:0008409; GO:0050779; GO:0034353; GO:0003729; GO:0000287; GO:0071028; GO:0000166; GO:0005634 5'-3' exonuclease activity; RNA destabilization; RNA pyrophosphohydrolase activity; mRNA binding; magnesium ion binding; nuclear mRNA surveillance; nucleotide binding; nucleus IPR013961; Decapping and exoribonuclease protein (DXO) (EC 3.1.13.-) (EC 3.6.1.-) (Dom-3 homolog Z) dxo dom3z Xenopus laevis (African clawed frog) TR37308_c7_g1_i5 Q5HZT0 DOM3Z_XENLA 7.00E-88 GO:0008409; GO:0050779; GO:0034353; GO:0003729; GO:0000287; GO:0071028; GO:0000166; GO:0005634 5'-3' exonuclease activity; RNA destabilization; RNA pyrophosphohydrolase activity; mRNA binding; magnesium ion binding; nuclear mRNA surveillance; nucleotide binding; nucleus IPR013961; Decapping and exoribonuclease protein (DXO) (EC 3.1.13.-) (EC 3.6.1.-) (Dom-3 homolog Z) dxo dom3z Xenopus laevis (African clawed frog) TR37308_c7_g1_i6 O77932 DOM3Z_HUMAN 5.00E-75 GO:0008409; GO:0050779; GO:0034353; GO:0003729; GO:0000287; GO:0071028; GO:0000166; GO:0005634 5'-3' exonuclease activity; RNA destabilization; RNA pyrophosphohydrolase activity; mRNA binding; magnesium ion binding; nuclear mRNA surveillance; nucleotide binding; nucleus IPR013961; Decapping and exoribonuclease protein (DXO) (EC 3.1.13.-) (EC 3.6.1.-) (Dom-3 homolog Z) DXO DOM3L DOM3Z NG6 Homo sapiens (Human) TR37308_c7_g2_i1 Q4GZT3 PKD2_BOVIN 1.00E-42 GO:0007259; GO:0035904; GO:0045180; GO:0009925; GO:0001658; GO:0005262; GO:0005509; GO:0048763; GO:0007050; GO:0005911; GO:0071498; GO:0071464; GO:0071470; GO:0042994; GO:0050982; GO:0003127; GO:0071910; GO:0001892; GO:0031941; GO:0001947; GO:0071458; GO:0071556; GO:0005887; GO:0030027; GO:0016020; GO:0072177; GO:0072284; GO:0072218; GO:0072214; GO:0072219; GO:0072235; GO:0072075; GO:0035502; GO:0072208; GO:0005932; GO:0072686; GO:0031512; GO:2000134; GO:0060315; GO:0021915; GO:0031513; GO:0060674; GO:0002133; GO:0071158; GO:0031659; GO:0031587; GO:0045429; GO:0045944; GO:0005267; GO:0030814; GO:0090279; GO:0042127; GO:0051209; GO:0061441; GO:0061333; GO:0021510; GO:0005245; GO:0005248 "JAK-STAT cascade; aorta development; basal cortex; basal plasma membrane; branching involved in ureteric bud morphogenesis; calcium channel activity; calcium ion binding; calcium-induced calcium release activity; cell cycle arrest; cell-cell junction; cellular response to fluid shear stress; cellular response to hydrostatic pressure; cellular response to osmotic stress; cytoplasmic sequestering of transcription factor; detection of mechanical stimulus; detection of nodal flow; determination of liver left/right asymmetry; embryonic placenta development; filamentous actin; heart looping; integral to cytosolic side of endoplasmic reticulum membrane; integral to lumenal side of endoplasmic reticulum membrane; integral to plasma membrane; lamellipodium; membrane; mesonephric duct development; metanephric S-shaped body morphogenesis; metanephric ascending thin limb development; metanephric cortex development; metanephric cortical collecting duct development; metanephric distal tubule development; metanephric mesenchyme development; metanephric part of ureteric bud development; metanephric smooth muscle tissue development; microtubule basal body; mitotic spindle; motile primary cilium; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of ryanodine-sensitive calcium-release channel activity; neural tube development; nonmotile primary cilium; placenta blood vessel development; polycystin complex; positive regulation of cell cycle arrest; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; positive regulation of nitric oxide biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; potassium channel activity; regulation of cAMP metabolic process; regulation of calcium ion import; regulation of cell proliferation; release of sequestered calcium ion into cytosol; renal artery morphogenesis; renal tubule morphogenesis; spinal cord development; voltage-gated calcium channel activity; voltage-gated sodium channel activity" IPR027359; IPR011992; IPR002048; IPR013122; IPR003915; Polycystin-2 (Polycystic kidney disease 2 protein homolog) PKD2 Bos taurus (Bovine) TR37308_c7_g3_i1 P42337 PK3CA_MOUSE 0 GO:0016303; GO:0035005; GO:0005943; GO:0005524; GO:0001525; GO:0006006; GO:0044029; GO:0030027; GO:2000811; GO:2000270; GO:0043524; GO:0005942; GO:0046934; GO:0048015; GO:0005886; GO:0033138; GO:0043491; GO:0030295; GO:0006468; GO:0004674; GO:2000653; GO:0040014 P01112; P26450 "1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; ATP binding; angiogenesis; glucose metabolic process; hypomethylation of CpG island; lamellipodium; negative regulation of anoikis; negative regulation of fibroblast apoptotic process; negative regulation of neuron apoptotic process; phosphatidylinositol 3-kinase complex; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphatidylinositol-mediated signaling; plasma membrane; positive regulation of peptidyl-serine phosphorylation; protein kinase B signaling cascade; protein kinase activator activity; protein phosphorylation; protein serine/threonine kinase activity; regulation of genetic imprinting; regulation of multicellular organism growth" IPR016024; IPR000008; IPR011009; IPR000403; IPR018936; IPR003113; IPR002420; IPR000341; IPR015433; IPR001263; "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)" Pik3ca Mus musculus (Mouse) TR37308_c7_g3_i2 P42336 PK3CA_HUMAN 3.00E-74 GO:0016303; GO:0035005; GO:0005943; GO:0005524; GO:0038095; GO:0038096; GO:0031295; GO:0050852; GO:0001525; GO:0060048; GO:0043542; GO:0007173; GO:0008543; GO:0006006; GO:0044029; GO:0045087; GO:0038028; GO:0030027; GO:0050900; GO:2000811; GO:0048011; GO:0046934; GO:0048015; GO:0005886; GO:0030168; GO:0033138; GO:0043491; GO:0030295; GO:0004674; GO:2000653; GO:0040014; GO:0044281; GO:0001944 P21860; P35568; P27986 "1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; ATP binding; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; T cell costimulation; T cell receptor signaling pathway; angiogenesis; cardiac muscle contraction; endothelial cell migration; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; glucose metabolic process; hypomethylation of CpG island; innate immune response; insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade; lamellipodium; leukocyte migration; negative regulation of anoikis; neurotrophin TRK receptor signaling pathway; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphatidylinositol-mediated signaling; plasma membrane; platelet activation; positive regulation of peptidyl-serine phosphorylation; protein kinase B signaling cascade; protein kinase activator activity; protein serine/threonine kinase activity; regulation of genetic imprinting; regulation of multicellular organism growth; small molecule metabolic process; vasculature development" IPR016024; IPR000008; IPR011009; IPR000403; IPR018936; IPR003113; IPR002420; IPR000341; IPR015433; IPR001263; "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)" PIK3CA Homo sapiens (Human) TR37309_c0_g1_i1 Q27HV0 OGT1_PIG 7.00E-10 GO:0006915; GO:0005829; GO:0080182; GO:0043984; GO:0043981; GO:0043982; GO:0000123; GO:0005547; GO:0048015; GO:0005886; GO:0045862; GO:0045944; GO:0016262; GO:0006493; GO:0006110 "apoptotic process; cytosol; histone H3-K4 trimethylation; histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase complex; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-mediated signaling; plasma membrane; positive regulation of proteolysis; positive regulation of transcription from RNA polymerase II promoter; protein N-acetylglucosaminyltransferase activity; protein O-linked glycosylation; regulation of glycolysis" IPR013026; IPR011990; IPR001440; IPR019734; Protein modification; protein glycosylation. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) OGT Sus scrofa (Pig) TR37309_c0_g1_i2 Q62018 CTR9_MOUSE 0 GO:0016593; GO:0007259; GO:0042169; GO:0016055; GO:0071222; GO:0001711; GO:0033523; GO:0080182; GO:0010390; GO:0070102; GO:0045638; GO:0000122; GO:0016607; GO:0051571; GO:2001162; GO:0032968; GO:0045944; GO:0019827; GO:0006351; GO:0035327 "Cdc73/Paf1 complex; JAK-STAT cascade; SH2 domain binding; Wnt receptor signaling pathway; cellular response to lipopolysaccharide; endodermal cell fate commitment; histone H2B ubiquitination; histone H3-K4 trimethylation; histone monoubiquitination; interleukin-6-mediated signaling pathway; negative regulation of myeloid cell differentiation; negative regulation of transcription from RNA polymerase II promoter; nuclear speck; positive regulation of histone H3-K4 methylation; positive regulation of histone H3-K79 methylation; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; stem cell maintenance; transcription, DNA-dependent; transcriptionally active chromatin" IPR013026; IPR011990; IPR001440; IPR013105; IPR019734; "RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) (Tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa) (TPR-containing, SH2-binding phosphoprotein of 150 kDa) (p150TSP)" Ctr9 Kiaa0155 Sh2bp1 Mus musculus (Mouse) TR37311_c0_g2_i1 Q4KLT0 RN217_XENLA 2.00E-62 GO:0016021; GO:0016874; GO:0016567; GO:0008270 integral to membrane; ligase activity; protein ubiquitination; zinc ion binding IPR002867; IPR001841; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase RNF217 (EC 6.3.2.-) (RING finger protein 217) rnf217 Xenopus laevis (African clawed frog) TR37312_c3_g1_i1 P27085 RS26_OCTVU 7.00E-42 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000892; 40S ribosomal protein S26 RPS26 Octopus vulgaris (Common octopus) TR37313_c1_g1_i1 P23416 GLRA2_HUMAN 4.00E-78 GO:0030054; GO:0034707; GO:0016934; GO:0016594; GO:0005887; GO:0007218; GO:0045211; GO:0007416; GO:0022824 cell junction; chloride channel complex; extracellular-glycine-gated chloride channel activity; glycine binding; integral to plasma membrane; neuropeptide signaling pathway; postsynaptic membrane; synapse assembly; transmitter-gated ion channel activity IPR006028; IPR008127; IPR008129; IPR006202; IPR006201; IPR006029; IPR018000; Glycine receptor subunit alpha-2 GLRA2 Homo sapiens (Human) TR37313_c1_g1_i2 Q24352 GBRAL_DROME 2.00E-20 GO:0004890; GO:0005261; GO:0030054; GO:0005254; GO:0034707; GO:0016933; GO:0016021; GO:0005886; GO:0045211 GABA-A receptor activity; cation channel activity; cell junction; chloride channel activity; chloride channel complex; extracellular-glycine-gated ion channel activity; integral to membrane; plasma membrane; postsynaptic membrane IPR006028; IPR006202; IPR006201; IPR006029; IPR018000; Gamma-aminobutyric acid receptor alpha-like (GABA(A) receptor alpha-like and glycine receptor-like subunit of Drosophila) (GRD) Grd CG7446 Drosophila melanogaster (Fruit fly) TR37315_c2_g1_i1 Q8VCV9 NAGTA_MOUSE 3.00E-09 GO:0016324; GO:0008643; GO:0016021; GO:0006814; GO:0015293 apical plasma membrane; carbohydrate transport; integral to membrane; sodium ion transport; symporter activity IPR011701; IPR016196; Sodium-dependent glucose transporter 1A Naglt1a Mus musculus (Mouse) TR37315_c3_g1_i1 A9JTG4 MFD4B_DANRE 2.00E-06 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR016196; Major facilitator superfamily domain-containing protein 4-B mfsd4b zgc:175151 Danio rerio (Zebrafish) (Brachydanio rerio) TR37315_c3_g1_i3 Q569T7 NAGT1_XENLA 6.00E-14 GO:0016324; GO:0008643; GO:0016021; GO:0006814; GO:0015293 apical plasma membrane; carbohydrate transport; integral to membrane; sodium ion transport; symporter activity IPR011701; IPR016196; Sodium-dependent glucose transporter 1 naglt1 Xenopus laevis (African clawed frog) TR37317_c1_g1_i1 Q8IVF4 DYH10_HUMAN 1.00E-173 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 10, axonemal (Axonemal beta dynein heavy chain 10) (Ciliary dynein heavy chain 10)" DNAH10 KIAA2017 Homo sapiens (Human) TR37317_c2_g1_i1 Q0VDD8 DYH14_HUMAN 2.00E-14 GO:0005524; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR026983; IPR024743; IPR024317; IPR004273; IPR027417; "Dynein heavy chain 14, axonemal (Axonemal beta dynein heavy chain 14) (Ciliary dynein heavy chain 14)" DNAH14 C1orf67 Homo sapiens (Human) TR37317_c3_g1_i1 Q8IVF4 DYH10_HUMAN 0 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 10, axonemal (Axonemal beta dynein heavy chain 10) (Ciliary dynein heavy chain 10)" DNAH10 KIAA2017 Homo sapiens (Human) TR37317_c3_g4_i1 Q3V0Q1 DYH12_MOUSE 6.00E-104 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018; GO:0016567 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement; protein ubiquitination IPR003593; IPR011704; IPR026983; IPR024317; IPR004273; IPR013602; IPR027417; Protein modification; protein ubiquitination. "Dynein heavy chain 12, axonemal (Axonemal beta dynein heavy chain 12) (Axonemal dynein heavy chain 12-like protein) (Axonemal dynein heavy chain 7-like protein) (Ciliary dynein heavy chain 12)" Dnah12 Dnah12l Dnah7l Dnahc12 Dnahc7l Mus musculus (Mouse) TR37318_c0_g1_i1 Q9VB11 UNC80_DROME 2.00E-93 GO:0005261; GO:0034703; GO:0055080 cation channel activity; cation channel complex; cation homeostasis Protein unc-80 homolog CG18437 Drosophila melanogaster (Fruit fly) TR37318_c2_g2_i1 Q8BLN6 UNC80_MOUSE 2.00E-177 GO:0016021 integral to membrane Protein unc-80 homolog (mUNC-80) Unc80 Kiaa1843 Mus musculus (Mouse) TR3732_c0_g1_i1 A0PK05 TMM72_HUMAN 1.00E-11 GO:0016021 integral to membrane Transmembrane protein 72 (Kidney-specific secretory protein of 37 kDa) TMEM72 C10orf127 KSP37 Homo sapiens (Human) TR37323_c2_g3_i1 Q502M6 ANR29_DANRE 3.00E-88 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) TR37323_c2_g3_i3 Q02357 ANK1_MOUSE 7.00E-38 GO:0030863; GO:0048821; GO:0016020; GO:0015672; GO:0006779; GO:0016529; GO:0007165; GO:0014731 cortical cytoskeleton; erythrocyte development; membrane; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; sarcoplasmic reticulum; signal transduction; spectrin-associated cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) TR37323_c2_g3_i4 Q502M6 ANR29_DANRE 3.00E-88 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) TR37324_c1_g1_i1 Q9Y7M7 YNT9_SCHPO 3.00E-107 GO:0005524; GO:0016021; GO:0005743; GO:0006839; GO:0006857; GO:0015440 ATP binding; integral to membrane; mitochondrial inner membrane; mitochondrial transport; oligopeptide transport; peptide-transporting ATPase activity IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; "ATP-dependent permease MDL1, mitochondrial (ABC transporter mdl1)" mdl1 SPBC9B6.09c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR37324_c1_g1_i2 Q54BU4 ABCB1_DICDI 3.00E-176 GO:0005524; GO:0043190; GO:0006935; GO:0031154; GO:0006972; GO:0016021; GO:0005739; GO:0015421; GO:0005886 ATP binding; ATP-binding cassette (ABC) transporter complex; chemotaxis; culmination involved in sorocarp development; hyperosmotic response; integral to membrane; mitochondrion; oligopeptide-transporting ATPase activity; plasma membrane IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; ABC transporter B family member 1 (ABC transporter ABCB.1) abcB1 mrpA DDB_G0293416 Dictyostelium discoideum (Slime mold) TR37324_c1_g2_i3 O80725 AB4B_ARATH 4.00E-12 GO:0005524; GO:0010329; GO:0010328; GO:0010540; GO:0009630; GO:0016021; GO:0005886; GO:0009506; GO:0009735; GO:0048767; GO:0008559 ATP binding; auxin efflux transmembrane transporter activity; auxin influx transmembrane transporter activity; basipetal auxin transport; gravitropism; integral to membrane; plasma membrane; plasmodesma; response to cytokinin stimulus; root hair elongation; xenobiotic-transporting ATPase activity IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; ABC transporter B family member 4 (ABC transporter ABCB.4) (AtABCB4) (Multidrug resistance protein 4) (P-glycoprotein 4) ABCB4 MDR4 PGP4 At2g47000 F14M4.17 Arabidopsis thaliana (Mouse-ear cress) TR37324_c1_g2_i4 Q5RKI8 ABCB8_RAT 8.00E-17 GO:0005524; GO:0042626; GO:0016021; GO:0005743 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; mitochondrial inner membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; "ATP-binding cassette sub-family B member 8, mitochondrial" Abcb8 Rattus norvegicus (Rat) TR37325_c0_g1_i1 P38148 PPS1_YEAST 6.00E-10 GO:0000188; GO:0033260; GO:0035335; GO:0004725; GO:0008138 inactivation of MAPK activity; nuclear cell cycle DNA replication; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Dual specificity protein phosphatase PPS1 (EC 3.1.3.16) (EC 3.1.3.48) PPS1 YBR276C YBR2013 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR37325_c0_g1_i2 O13453 PMP1_SCHPO 2.00E-08 GO:0033550; GO:0017017; GO:0007049; GO:0030644; GO:0071472; GO:0005829; GO:0005634; GO:0090028; GO:0022604; GO:0032465 MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; cell cycle; cellular chloride ion homeostasis; cellular response to salt stress; cytosol; nucleus; positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion; regulation of cell morphogenesis; regulation of cytokinesis IPR000340; IPR020422; IPR024950; IPR000387; Tyrosine-protein phosphatase pmp1 (EC 3.1.3.48) pmp1 SPBC1685.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR37325_c0_g1_i3 O54838 DUS5_RAT 1.00E-19 GO:0017017; GO:0001706; GO:0045892; GO:0005654; GO:0035335; GO:0004725 "MAP kinase tyrosine/serine/threonine phosphatase activity; endoderm formation; negative regulation of transcription, DNA-dependent; nucleoplasm; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity" IPR000340; IPR020422; IPR024950; IPR008343; IPR001763; IPR000387; IPR016130; Dual specificity protein phosphatase 5 (EC 3.1.3.16) (EC 3.1.3.48) (MAP-kinase phosphatase CPG21) Dusp5 Rattus norvegicus (Rat) TR37325_c0_g1_i4 Q5BIP9 DUS18_BOVIN 3.00E-37 GO:0017017; GO:0005743; GO:0005634; GO:0035335; GO:0004725; GO:0008138 MAP kinase tyrosine/serine/threonine phosphatase activity; mitochondrial inner membrane; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR020417; IPR020420; IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Dual specificity protein phosphatase 18 (EC 3.1.3.16) (EC 3.1.3.48) DUSP18 Bos taurus (Bovine) TR37325_c0_g1_i6 Q0IID7 DUS10_BOVIN 1.00E-14 GO:0005794; GO:0017017; GO:0005737; GO:0046329; GO:0043508; GO:0005634; GO:0035335; GO:0004725 Golgi apparatus; MAP kinase tyrosine/serine/threonine phosphatase activity; cytoplasm; negative regulation of JNK cascade; negative regulation of JUN kinase activity; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR020417; IPR000340; IPR020422; IPR024950; IPR008343; IPR001763; IPR000387; IPR016130; Dual specificity protein phosphatase 10 (EC 3.1.3.16) (EC 3.1.3.48) DUSP10 Bos taurus (Bovine) TR37325_c0_g1_i7 Q6AXW7 DUS18_RAT 6.00E-40 GO:0017017; GO:0031314; GO:0005758; GO:0005634; GO:0035335; GO:0004725; GO:0008138 MAP kinase tyrosine/serine/threonine phosphatase activity; extrinsic to mitochondrial inner membrane; mitochondrial intermembrane space; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR020417; IPR020420; IPR000340; IPR020422; IPR024950; IPR000387; IPR016130; Dual specificity protein phosphatase 18 (EC 3.1.3.16) (EC 3.1.3.48) Dusp18 Rattus norvegicus (Rat) TR37326_c0_g1_i1 B4N072 IHOG_DROWI 8.00E-09 GO:0008201; GO:0016021; GO:0042803; GO:0007224 heparin binding; integral to membrane; protein homodimerization activity; smoothened signaling pathway IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Interference hedgehog iHog GK24246 Drosophila willistoni (Fruit fly) TR37326_c0_g1_i2 Q26474 LACH_SCHAM 7.00E-27 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Lachesin LAC Schistocerca americana (American grasshopper) TR37326_c0_g1_i3 B4N072 IHOG_DROWI 7.00E-09 GO:0008201; GO:0016021; GO:0042803; GO:0007224 heparin binding; integral to membrane; protein homodimerization activity; smoothened signaling pathway IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Interference hedgehog iHog GK24246 Drosophila willistoni (Fruit fly) TR37326_c0_g1_i4 Q98892 OBCAM_CHICK 3.00E-19 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Opioid-binding protein/cell adhesion molecule homolog (Neurite inhibitor GP55-A) (OBCAM protein gamma isoform) OPCML Gallus gallus (Chicken) TR37326_c0_g1_i5 Q26474 LACH_SCHAM 4.00E-28 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Lachesin LAC Schistocerca americana (American grasshopper) TR37327_c0_g2_i3 O62515 PAHX_CAEEL 3.00E-08 GO:0031418; GO:0006631; GO:0046872; GO:0048244 L-ascorbic acid binding; fatty acid metabolic process; metal ion binding; phytanoyl-CoA dioxygenase activity IPR008775; Lipid metabolism; fatty acid metabolism. Probable phytanoyl-CoA dioxygenase (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH) ZK550.6 Caenorhabditis elegans TR37327_c0_g2_i5 O62515 PAHX_CAEEL 1.00E-08 GO:0031418; GO:0006631; GO:0046872; GO:0048244 L-ascorbic acid binding; fatty acid metabolic process; metal ion binding; phytanoyl-CoA dioxygenase activity IPR008775; Lipid metabolism; fatty acid metabolism. Probable phytanoyl-CoA dioxygenase (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH) ZK550.6 Caenorhabditis elegans TR37328_c2_g1_i2 Q8IVL1 NAV2_HUMAN 6.00E-09 GO:0005524; GO:0021563; GO:0004386; GO:0008201; GO:0005614; GO:0007626; GO:0005634; GO:0021554; GO:0003025; GO:0007608; GO:0007605; GO:0021564 ATP binding; glossopharyngeal nerve development; helicase activity; heparin binding; interstitial matrix; locomotory behavior; nucleus; optic nerve development; regulation of systemic arterial blood pressure by baroreceptor feedback; sensory perception of smell; sensory perception of sound; vagus nerve development IPR003593; IPR001715; IPR027417; Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2 Homo sapiens (Human) TR37329_c4_g2_i1 Q2YDD0 HSP7E_BOVIN 2.00E-129 GO:0005524; GO:0005829; GO:0005840 ATP binding; cytosol; ribosome IPR018181; IPR013126; Heat shock 70 kDa protein 14 HSPA14 Bos taurus (Bovine) TR37329_c4_g2_i2 Q2YDD0 HSP7E_BOVIN 3.00E-140 GO:0005524; GO:0005829; GO:0005840 ATP binding; cytosol; ribosome IPR018181; IPR013126; Heat shock 70 kDa protein 14 HSPA14 Bos taurus (Bovine) TR37330_c1_g2_i1 A6H779 FBXL2_BOVIN 2.00E-19 GO:0016020; GO:0006513; GO:0006511; GO:0004842 membrane; protein monoubiquitination; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR001810; IPR006553; F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) FBXL2 FBL2 Bos taurus (Bovine) TR37330_c1_g2_i2 B5X441 FXL15_SALSA 9.00E-10 GO:0000086; GO:0019005; GO:0031146; GO:0030282; GO:0005737; GO:0009953; GO:0030513; GO:0016567 G2/M transition of mitotic cell cycle; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; bone mineralization; cytoplasm; dorsal/ventral pattern formation; positive regulation of BMP signaling pathway; protein ubiquitination IPR001810; Protein modification; protein ubiquitination. F-box/LRR-repeat protein 15 fbxl15 Salmo salar (Atlantic salmon) TR37331_c0_g2_i4 P39598 YWBO_BACSU 3.00E-12 GO:0015035 protein disulfide oxidoreductase activity IPR001853; IPR012336; Uncharacterized protein YwbO ywbO BSU38250 ipa-30d Bacillus subtilis (strain 168) TR37332_c0_g1_i1 Q9NX36 DJC28_HUMAN 2.00E-68 IPR001623; IPR018961; DnaJ homolog subfamily C member 28 DNAJC28 C21orf55 C21orf78 Homo sapiens (Human) TR37332_c0_g1_i3 Q9NX36 DJC28_HUMAN 3.00E-68 IPR001623; IPR018961; DnaJ homolog subfamily C member 28 DNAJC28 C21orf55 C21orf78 Homo sapiens (Human) TR37333_c0_g3_i1 P29775 ETS4_DROME 4.00E-15 GO:0005634; GO:0043565; GO:0003700 nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR000418; IPR003118; IPR013761; IPR011991; DNA-binding protein D-ETS-4 Ets98B ETS-4 CG5583 Drosophila melanogaster (Fruit fly) TR37333_c0_g3_i2 Q1RML4 SPIC_BOVIN 5.00E-08 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR011991; Transcription factor Spi-C SPIC Bos taurus (Bovine) TR37333_c0_g3_i3 Q32LN0 EHF_BOVIN 4.00E-35 GO:0030855; GO:0005634; GO:0045893; GO:0043565; GO:0003700; GO:0006351 "epithelial cell differentiation; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; ETS homologous factor (ETS domain-containing transcription factor) EHF Bos taurus (Bovine) TR37333_c0_g3_i5 P17433 SPI1_MOUSE 5.00E-08 GO:0003723; GO:0000980; GO:0001205; GO:0060033; GO:1902262; GO:0030218; GO:0030851; GO:0030098; GO:0002320; GO:0030225; GO:0043011; GO:0045347; GO:0000790; GO:0035019; GO:0005667 Q99684; P70338; Q99K48 RNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; anatomical structure regression; apoptotic process involved in patterning of blood vessels; erythrocyte differentiation; granulocyte differentiation; lymphocyte differentiation; lymphoid progenitor cell differentiation; macrophage differentiation; myeloid dendritic cell differentiation; negative regulation of MHC class II biosynthetic process; nuclear chromatin; somatic stem cell maintenance; transcription factor complex IPR000418; IPR011991; Transcription factor PU.1 (31 kDa-transforming protein) (SFFV proviral integration 1 protein) Spi1 Sfpi-1 Sfpi1 Mus musculus (Mouse) TR37334_c1_g1_i1 Q9GR88 ERF1_POLMI 0 GO:0005737; GO:0016149 "cytoplasm; translation release factor activity, codon specific" IPR005140; IPR005141; IPR005142; IPR004403; IPR024049; Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) ERF1 Polyandrocarpa misakiensis (Tunicate) TR37335_c2_g2_i1 P18850 ATF6A_HUMAN 4.00E-46 GO:0000139; GO:0006987; GO:0005789; GO:0016021; GO:0005635; GO:0005654; GO:0006990; GO:0006457; GO:0043565; GO:0003700; GO:0003713; GO:0006351 Q68CJ9 "Golgi membrane; activation of signaling protein activity involved in unfolded protein response; endoplasmic reticulum membrane; integral to membrane; nuclear envelope; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; protein folding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription, DNA-dependent" IPR004827; Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha] ATF6 Homo sapiens (Human) TR37337_c0_g1_i1 Q8N0Z6 TTC5_HUMAN 2.00E-137 GO:0003677; GO:0006281; GO:0003682; GO:0005737; GO:0005634; GO:0045944 DNA binding; DNA repair; chromatin binding; cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter IPR013026; IPR011990; IPR019734; Tetratricopeptide repeat protein 5 (TPR repeat protein 5) (Stress-responsive activator of p300) (Strap) TTC5 Homo sapiens (Human) TR37337_c0_g1_i2 Q0P5H9 TTC5_BOVIN 3.00E-95 GO:0003677; GO:0006281; GO:0003682; GO:0005737; GO:0005634; GO:0045944 DNA binding; DNA repair; chromatin binding; cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter IPR013026; IPR011990; IPR013105; IPR019734; Tetratricopeptide repeat protein 5 (TPR repeat protein 5) (Stress-responsive activator of p300) (Strap) TTC5 Bos taurus (Bovine) TR37338_c0_g1_i2 Q8BGC3 MOT12_MOUSE 2.00E-25 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) Slc16a12 Mct12 Mus musculus (Mouse) TR37339_c0_g1_i1 Q3UK37 CN080_MOUSE 6.00E-16 IPR027996; IPR028100; Uncharacterized protein C14orf80 homolog Mus musculus (Mouse) TR37341_c1_g2_i1 P55214 CASP7_MESAU 2.00E-07 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR015471; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; "Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11; Caspase-7, N-terminally processed]" CASP7 MCH3 Mesocricetus auratus (Golden hamster) TR37341_c1_g2_i2 Q8MJU1 CASP3_FELCA 1.00E-06 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Felis catus (Cat) (Felis silvestris catus) TR37341_c1_g3_i1 P29594 CASP2_MOUSE 2.00E-07 GO:0006977; GO:0007568; GO:0007420; GO:0071260; GO:0097153; GO:0005737; GO:0097192; GO:0035234; GO:0001554; GO:0016020; GO:0005739; GO:0043066; GO:0003407; GO:0005634; GO:0043065; GO:2001235; GO:0043525; GO:0016485; GO:0006508 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; aging; brain development; cellular response to mechanical stimulus; cysteine-type endopeptidase activity involved in apoptotic process; cytoplasm; extrinsic apoptotic signaling pathway in absence of ligand; germ cell programmed cell death; luteolysis; membrane; mitochondrion; negative regulation of apoptotic process; neural retina development; nucleus; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of neuron apoptotic process; protein processing; proteolysis" IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] Casp2 Ich1 Nedd-2 Nedd2 Mus musculus (Mouse) TR37342_c2_g1_i2 P30754 CAFF_RIFPA 3.00E-18 GO:0005581 collagen IPR008160; Fibril-forming collagen alpha chain (Fragment) Riftia pachyptila (Vent tube worm) TR37342_c2_g1_i3 P27393 CO4A2_ASCSU 3.00E-133 GO:0005604; GO:0005581; GO:0005201 basement membrane; collagen; extracellular matrix structural constituent IPR016187; IPR008160; IPR001442; Collagen alpha-2(IV) chain Ascaris suum (Pig roundworm) (Ascaris lumbricoides) TR37342_c2_g2_i1 O46392 CO1A2_CANFA 1.00E-09 GO:0005581; GO:0005201; GO:0046872 collagen; extracellular matrix structural constituent; metal ion binding IPR008160; IPR000885; Collagen alpha-2(I) chain (Alpha-2 type I collagen) COL1A2 Canis familiaris (Dog) (Canis lupus familiaris) TR37342_c2_g2_i2 A0MSJ1 CRA1B_DANRE 4.00E-07 GO:0030282; GO:0005581; GO:0005201; GO:0046872; GO:0048570; GO:0001501 bone mineralization; collagen; extracellular matrix structural constituent; metal ion binding; notochord morphogenesis; skeletal system development IPR008160; IPR008985; IPR013320; IPR000885; IPR001791; Collagen alpha-1(XXVII) chain B col27a1b col27a1 Danio rerio (Zebrafish) (Brachydanio rerio) TR37342_c2_g3_i1 P13942 COBA2_HUMAN 6.00E-20 GO:0051216; GO:0030574; GO:0030199; GO:0005592; GO:0005788; GO:0022617; GO:0030020; GO:0046872; GO:0030674; GO:0007605; GO:0060023 Q16832 "cartilage development; collagen catabolic process; collagen fibril organization; collagen type XI; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular matrix structural constituent conferring tensile strength; metal ion binding; protein binding, bridging; sensory perception of sound; soft palate development" IPR008160; IPR008985; IPR013320; IPR000885; IPR001791; Collagen alpha-2(XI) chain COL11A2 Homo sapiens (Human) TR37344_c0_g1_i2 P30551 CCKAR_RAT 8.00E-11 GO:0031532; GO:0032870; GO:0004951; GO:0007204; GO:0005783; GO:0005768; GO:0001696; GO:0030073; GO:0016021; GO:0005764; GO:0031100; GO:0031016; GO:0030157; GO:0005886; GO:0090274; GO:0002023; GO:0051924; GO:0043266; GO:0051384; GO:0009408; GO:0032496; GO:0007584; GO:0009314; GO:0042594; GO:0001659; GO:0043195 actin cytoskeleton reorganization; cellular response to hormone stimulus; cholecystokinin receptor activity; elevation of cytosolic calcium ion concentration; endoplasmic reticulum; endosome; gastric acid secretion; insulin secretion; integral to membrane; lysosome; organ regeneration; pancreas development; pancreatic juice secretion; plasma membrane; positive regulation of somatostatin secretion; reduction of food intake in response to dietary excess; regulation of calcium ion transport; regulation of potassium ion transport; response to glucocorticoid stimulus; response to heat; response to lipopolysaccharide; response to nutrient; response to radiation; response to starvation; temperature homeostasis; terminal bouton IPR009126; IPR000596; IPR015276; IPR000276; IPR017452; Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) Cckar Rattus norvegicus (Rat) TR37345_c3_g1_i1 P53356 HTK16_HYDVU 6.00E-78 GO:0005524; GO:0004715; GO:0018108 ATP binding; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR002110; IPR020683; IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR008266; IPR020635; Tyrosine-protein kinase HTK16 (EC 2.7.10.2) HTK16 Hydra vulgaris (Hydra) (Hydra attenuata) TR37345_c3_g1_i2 Q01484 ANK2_HUMAN 3.00E-12 GO:0051117; GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0007411; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005829; GO:0005887; GO:0014704; GO:0044325; GO:0086046; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307; GO:0070296 P11532-5; P62993 "ATPase binding; M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; axon guidance; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; cytosol; integral to plasma membrane; intercalated disc; ion channel binding; membrane depolarization involved in regulation of SA node cell action potential; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization; sarcoplasmic reticulum calcium ion transport" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) TR37346_c3_g4_i1 Q8R5F7 IFIH1_MOUSE 4.00E-57 GO:0005524; GO:0003677; GO:0005737; GO:0051607; GO:0003725; GO:0004386; GO:0045087; GO:0005634; GO:0032727; GO:0032728; GO:0016925; GO:0042981; GO:0009615; GO:0043021; GO:0003727; GO:0008270 ATP binding; DNA binding; cytoplasm; defense response to virus; double-stranded RNA binding; helicase activity; innate immune response; nucleus; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; protein sumoylation; regulation of apoptotic process; response to virus; ribonucleoprotein complex binding; single-stranded RNA binding; zinc ion binding IPR001315; IPR011029; IPR006935; IPR014001; IPR001650; IPR027417; IPR021673; Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Helicase with 2 CARD domains) (Helicard) (Interferon induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (RIG-I-like receptor 2) (RLR-2) Ifih1 Mus musculus (Mouse) TR37346_c3_g4_i3 Q58083 H669_METJA 2.00E-07 GO:0005524; GO:0008026; GO:0003723 ATP binding; ATP-dependent helicase activity; RNA binding IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase MJ0669 (EC 3.6.4.13) MJ0669 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR37346_c3_g4_i4 Q8LMR2 DCL1_ORYSJ 7.00E-08 GO:0005524; GO:0003723; GO:0004386; GO:0046872; GO:0007275; GO:0090305; GO:0005634; GO:0035196; GO:0004525 ATP binding; RNA binding; helicase activity; metal ion binding; multicellular organismal development; nucleic acid phosphodiester bond hydrolysis; nucleus; production of miRNAs involved in gene silencing by miRNA; ribonuclease III activity IPR005034; IPR014720; IPR014001; IPR001650; IPR027417; IPR003100; IPR000999; Endoribonuclease Dicer homolog 1 (Dicer-like protein 1) (OsDCL1) (EC 3.1.26.-) DCL1 Os03g0121800 LOC_Os03g02970 OJ1705B08.11 OsJ_09217 Oryza sativa subsp. japonica (Rice) TR37346_c3_g4_i5 A1CBC9 DCL1_ASPCL 2.00E-09 GO:0005524; GO:0003677; GO:0003723; GO:0006396; GO:0051607; GO:0004386; GO:0046872; GO:0050688; GO:0004525 ATP binding; DNA binding; RNA binding; RNA processing; defense response to virus; helicase activity; metal ion binding; regulation of defense response to virus; ribonuclease III activity IPR005034; IPR006935; IPR014001; IPR001650; IPR027417; IPR000999; Dicer-like protein 1 [Includes: Endoribonuclease dcl1 (EC 3.1.26.-); ATP-dependent helicase dcl1 (EC 3.6.4.-)] dcl1 ACLA_014840 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) TR37346_c3_g4_i6 Q9BYX4 IFIH1_HUMAN 2.00E-54 GO:0005524; GO:0003677; GO:0039528; GO:0005829; GO:0009597; GO:0003725; GO:0004386; GO:0045087; GO:0019048; GO:0032480; GO:0005634; GO:0032727; GO:0032728; GO:0016925; GO:0042981; GO:0034344; GO:0043021; GO:0003727; GO:0008270 Q7Z434; P11207; P30927; Q9EMA9; P04487 ATP binding; DNA binding; cytoplasmic pattern recognition receptor signaling pathway in response to virus; cytosol; detection of virus; double-stranded RNA binding; helicase activity; innate immune response; modulation by virus of host morphology or physiology; negative regulation of type I interferon production; nucleus; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; protein sumoylation; regulation of apoptotic process; regulation of type III interferon production; ribonucleoprotein complex binding; single-stranded RNA binding; zinc ion binding IPR001315; IPR011029; IPR006935; IPR014001; IPR001650; IPR027417; IPR021673; Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116) IFIH1 MDA5 RH116 Homo sapiens (Human) TR37346_c3_g4_i8 Q9UT23 MFH1_SCHPO 3.00E-10 GO:0005524; GO:0043140; GO:1990163; GO:0033567; GO:0071821; GO:0005829; GO:0000400; GO:1902346; GO:0045128; GO:0005730; GO:0071932; GO:0035861 "ATP binding; ATP-dependent 3'-5' DNA helicase activity; ATP-dependent four-way junction helicase activity; DNA replication, Okazaki fragment processing; FANCM-MHF complex; cytosol; four-way junction DNA binding; meiotic strand displacement involved in double-strand break repair via SDSA; negative regulation of reciprocal meiotic recombination; nucleolus; replication fork reversal; site of double-strand break" IPR011545; IPR002464; IPR014001; IPR001650; IPR027417; ATP-dependent DNA helicase mfh1 (EC 3.6.4.12) (FancM homolog protein 1) mfh1 SPAC9.05 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR37347_c1_g1_i1 Q9DE13 BAZ2B_CHICK 2.00E-18 GO:0003677; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR016024; IPR001487; IPR018359; IPR004022; IPR018500; IPR018501; IPR016177; IPR001739; IPR011011; IPR001965; IPR019787; IPR013083; Bromodomain adjacent to zinc finger domain protein 2B (Extracellular matrix protein F22) BAZ2B Gallus gallus (Chicken) TR37347_c2_g1_i1 Q9BXF3 CECR2_HUMAN 1.00E-56 GO:0043044; GO:0090537; GO:0006309; GO:0090102; GO:0000910; GO:0007010; GO:0060122; GO:0001842; GO:0001843; GO:0005719; GO:0016192 ATP-dependent chromatin remodeling; CERF complex; apoptotic DNA fragmentation; cochlea development; cytokinesis; cytoskeleton organization; inner ear receptor stereocilium organization; neural fold formation; neural tube closure; nuclear euchromatin; vesicle-mediated transport IPR001487; IPR018359; Cat eye syndrome critical region protein 2 CECR2 KIAA1740 Homo sapiens (Human) TR37347_c3_g1_i1 Q3T0B7 RS27L_BOVIN 1.00E-26 GO:0046872; GO:0005840; GO:0003735; GO:0006412 metal ion binding; ribosome; structural constituent of ribosome; translation IPR000592; IPR023407; IPR011332; 40S ribosomal protein S27-like RPS27L Bos taurus (Bovine) TR37349_c4_g1_i2 Q5AL10 COX19_CANAL 2.00E-19 GO:0005758 mitochondrial intermembrane space Cytochrome c oxidase assembly protein COX19 COX19 CaO19.12432 CaO19.4967 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) TR37349_c4_g1_i3 Q54IA0 COX19_DICDI 2.00E-19 GO:0005829 cytosol IPR009069; Cytochrome c oxidase assembly protein COX19 cox19 DDB_G0288903 Dictyostelium discoideum (Slime mold) TR37349_c6_g1_i1 Q9EQD2 NPFF2_RAT 2.00E-41 GO:0015629; GO:0016021; GO:0008188; GO:0007218; GO:0005886; GO:0043408; GO:0045761; GO:2000479 actin cytoskeleton; integral to membrane; neuropeptide receptor activity; neuropeptide signaling pathway; plasma membrane; regulation of MAPK cascade; regulation of adenylate cyclase activity; regulation of cAMP-dependent protein kinase activity IPR000276; IPR017452; IPR005395; IPR005397; Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide G-protein coupled receptor) Npffr2 Gpr74 Npff2 Npgpr Rattus norvegicus (Rat) TR37351_c0_g2_i2 Q8BX80 ENASE_MOUSE 2.00E-112 GO:0005829; GO:0033925 cytosol; mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity IPR001357; IPR005201; Cytosolic endo-beta-N-acetylglucosaminidase (ENGase) (EC 3.2.1.96) Engase Mus musculus (Mouse) TR37351_c1_g2_i1 Q9NPI1 BRD7_HUMAN 2.00E-65 GO:0016055; GO:0007049; GO:0005737; GO:0070577; GO:2000134; GO:0008285; GO:0045892; GO:0005634; GO:0035066; GO:0045893; GO:0006357; GO:0003713; GO:0003714; GO:0008134; GO:0044212; GO:0006351 Q09472; Q9BUJ2; P04637 "Wnt receptor signaling pathway; cell cycle; cytoplasm; histone acetyl-lysine binding; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of histone acetylation; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcription corepressor activity; transcription factor binding; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR001487; IPR021900; Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) BRD7 BP75 CELTIX1 Homo sapiens (Human) TR37351_c2_g1_i1 O94761 RECQ4_HUMAN 0 GO:0005524; GO:0043140; GO:0006310; GO:0006281; GO:0006260; GO:0000733; GO:0000405; GO:0005737; GO:0007275; GO:0005634; GO:0008270 ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA recombination; DNA repair; DNA replication; DNA strand renaturation; bubble DNA binding; cytoplasm; multicellular organismal development; nucleus; zinc ion binding IPR011545; IPR004589; IPR021110; IPR014001; IPR001650; IPR027417; IPR001878; "ATP-dependent DNA helicase Q4 (EC 3.6.4.12) (DNA helicase, RecQ-like type 4) (RecQ4) (RTS) (RecQ protein-like 4)" RECQL4 RECQ4 Homo sapiens (Human) TR37351_c2_g1_i2 Q14191 WRN_HUMAN 1.00E-30 GO:0043138; GO:0008408; GO:0005524; GO:0043140; GO:0004003; GO:0006310; GO:0000731; GO:0051880; GO:0000403; GO:0006284; GO:0000405; GO:0007569; GO:0071480; GO:0009267; GO:0005813; GO:0006302; GO:0009378; GO:0000287; GO:0030145; GO:0010259; GO:0005730; GO:0032066; GO:0005654; GO:0051345; GO:0032403; GO:0042803; GO:0042981; GO:0040009; GO:0031297; GO:0001302; GO:0010225; GO:0006979; GO:0000723 P54132; P39748; P09874; P43351; P27694; Q96EB6; Q15554; P04637; P12956 3'-5' DNA helicase activity; 3'-5' exonuclease activity; ATP binding; ATP-dependent 3'-5' DNA helicase activity; ATP-dependent DNA helicase activity; DNA recombination; DNA synthesis involved in DNA repair; G-quadruplex DNA binding; Y-form DNA binding; base-excision repair; bubble DNA binding; cell aging; cellular response to gamma radiation; cellular response to starvation; centrosome; double-strand break repair; four-way junction helicase activity; magnesium ion binding; manganese ion binding; multicellular organismal aging; nucleolus; nucleolus to nucleoplasm transport; nucleoplasm; positive regulation of hydrolase activity; protein complex binding; protein homodimerization activity; regulation of apoptotic process; regulation of growth rate; replication fork processing; replicative cell aging; response to UV-C; response to oxidative stress; telomere maintenance IPR002562; IPR011545; IPR004589; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR012337; IPR018982; IPR011991; "Werner syndrome ATP-dependent helicase (EC 3.6.4.12) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2)" WRN RECQ3 RECQL2 Homo sapiens (Human) TR37351_c2_g1_i3 O94761 RECQ4_HUMAN 2.00E-118 GO:0005524; GO:0043140; GO:0006310; GO:0006281; GO:0006260; GO:0000733; GO:0000405; GO:0005737; GO:0007275; GO:0005634; GO:0008270 ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA recombination; DNA repair; DNA replication; DNA strand renaturation; bubble DNA binding; cytoplasm; multicellular organismal development; nucleus; zinc ion binding IPR011545; IPR004589; IPR021110; IPR014001; IPR001650; IPR027417; IPR001878; "ATP-dependent DNA helicase Q4 (EC 3.6.4.12) (DNA helicase, RecQ-like type 4) (RecQ4) (RTS) (RecQ protein-like 4)" RECQL4 RECQ4 Homo sapiens (Human) TR37351_c2_g1_i4 Q19546 WRN_CAEEL 2.00E-21 GO:0005524; GO:0043140; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0005694; GO:0008340; GO:0040007; GO:0005654; GO:0010212 ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA binding; DNA recombination; DNA repair; DNA replication; chromosome; determination of adult lifespan; growth; nucleoplasm; response to ionizing radiation IPR011545; IPR004589; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR018982; IPR011991; Probable Werner syndrome ATP-dependent helicase homolog 1 (EC 3.6.4.12) wrn-1 F18C5.2 Caenorhabditis elegans TR37355_c1_g2_i1 Q04786 HEX_VIBVL 6.00E-81 GO:0004563; GO:0006032; GO:0030247; GO:0000272 beta-N-acetylhexosaminidase activity; chitin catabolic process; polysaccharide binding; polysaccharide catabolic process IPR025705; IPR008965; IPR012291; IPR004866; IPR013812; IPR015883; IPR015882; IPR013781; IPR017853; IPR014756; Glycan degradation; chitin degradation. Beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Chitobiase) (N-acetyl-beta-glucosaminidase) hex Vibrio vulnificus TR37355_c7_g2_i2 Q54468 CHB_SERMA 1.00E-58 GO:0004563; GO:0006032; GO:0042597; GO:0030247; GO:0000272 beta-N-acetylhexosaminidase activity; chitin catabolic process; periplasmic space; polysaccharide binding; polysaccharide catabolic process IPR025705; IPR008965; IPR012291; IPR004866; IPR004867; IPR013812; IPR015883; IPR015882; IPR013781; IPR017853; IPR014756; Glycan degradation; chitin degradation. Chitobiase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (N-acetyl-beta-glucosaminidase) chb Serratia marcescens TR37358_c1_g1_i7 Q9CX00 IST1_MOUSE 3.00E-74 GO:0007049; GO:0051301; GO:0016023; GO:0048672 cell cycle; cell division; cytoplasmic membrane-bounded vesicle; positive regulation of collateral sprouting IPR005061; IST1 homolog Ist1 Kiaa0174 Mus musculus (Mouse) TR37359_c0_g1_i1 Q9WV34 MPP2_MOUSE 3.00E-147 IPR008145; IPR008144; IPR020590; IPR004172; IPR014775; IPR027417; IPR001478; IPR011511; IPR001452; MAGUK p55 subfamily member 2 (Discs large homolog 2) (Protein MPP2) Mpp2 Dlgh2 Mus musculus (Mouse) TR37359_c0_g1_i2 Q62915 CSKP_RAT 2.00E-97 GO:0005524; GO:0005516; GO:0004683; GO:0060170; GO:0005829; GO:0030425; GO:0006886; GO:0005634; GO:0042734; GO:0008022; GO:0043234; GO:0006461; GO:0003713 O94868 ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; cilium membrane; cytosol; dendrite; intracellular protein transport; nucleus; presynaptic membrane; protein C-terminus binding; protein complex; protein complex assembly; transcription coactivator activity IPR008145; IPR008144; IPR020590; IPR011009; IPR004172; IPR014775; IPR027417; IPR001478; IPR000719; IPR002290; IPR011511; IPR001452; Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) Cask Rattus norvegicus (Rat) TR3736_c0_g1_i1 Q9D6J1 CERS4_MOUSE 4.00E-07 GO:0046513; GO:0005783; GO:0005789; GO:0016021; GO:0031965; GO:0043565; GO:0003700; GO:0050291 ceramide biosynthetic process; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nuclear membrane; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sphingosine N-acyltransferase activity IPR001356; IPR009057; IPR016439; IPR006634; Ceramide synthase 4 (CerS4) (LAG1 longevity assurance homolog 4) (Translocating chain-associating membrane protein homolog 1) (TRAM homolog 1) Cers4 Lass4 Trh1 Mus musculus (Mouse) TR37360_c4_g2_i1 P04323 POL3_DROME 1.00E-31 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR37360_c7_g1_i1 Q09575 YRD6_CAEEL 2.00E-28 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR37360_c9_g3_i3 Q8WWH5 TRUB1_HUMAN 2.00E-09 GO:0003723; GO:0009982; GO:0001522; GO:0008033 RNA binding; pseudouridine synthase activity; pseudouridine synthesis; tRNA processing IPR002501; IPR020103; IPR014780; Probable tRNA pseudouridine synthase 1 (EC 5.4.99.-) TRUB1 PUS4 Homo sapiens (Human) TR37360_c9_g3_i4 Q5XGG2 TRUB2_XENTR 7.00E-58 GO:0003723; GO:0009982; GO:0001522; GO:0008033 RNA binding; pseudouridine synthase activity; pseudouridine synthesis; tRNA processing IPR002501; IPR020103; Probable tRNA pseudouridine synthase 2 (EC 5.4.99.-) trub2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37361_c4_g1_i1 Q9UHL4 DPP2_HUMAN 5.00E-143 GO:0004177; GO:0016023; GO:0005829; GO:0008239; GO:0005576; GO:0005764; GO:0006508; GO:0008236 aminopeptidase activity; cytoplasmic membrane-bounded vesicle; cytosol; dipeptidyl-peptidase activity; extracellular region; lysosome; proteolysis; serine-type peptidase activity IPR008758; Dipeptidyl peptidase 2 (EC 3.4.14.2) (Dipeptidyl aminopeptidase II) (Dipeptidyl peptidase 7) (Dipeptidyl peptidase II) (DPP II) (Quiescent cell proline dipeptidase) DPP7 DPP2 QPP Homo sapiens (Human) TR37361_c4_g1_i2 P34610 PCP1_CAEEL 3.00E-39 GO:0006508; GO:0008236 proteolysis; serine-type peptidase activity IPR008758; Putative serine protease pcp-1 (EC 3.4.-.-) pcp-1 ZK112.1 Caenorhabditis elegans TR37361_c4_g1_i3 Q9UHL4 DPP2_HUMAN 3.00E-138 GO:0004177; GO:0016023; GO:0005829; GO:0008239; GO:0005576; GO:0005764; GO:0006508; GO:0008236 aminopeptidase activity; cytoplasmic membrane-bounded vesicle; cytosol; dipeptidyl-peptidase activity; extracellular region; lysosome; proteolysis; serine-type peptidase activity IPR008758; Dipeptidyl peptidase 2 (EC 3.4.14.2) (Dipeptidyl aminopeptidase II) (Dipeptidyl peptidase 7) (Dipeptidyl peptidase II) (DPP II) (Quiescent cell proline dipeptidase) DPP7 DPP2 QPP Homo sapiens (Human) TR37362_c1_g1_i1 Q99M85 SCRT1_MOUSE 3.00E-54 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Transcriptional repressor scratch 1 (Scratch homolog 1 zinc finger protein) (SCRT) (Scratch 1) (mScrt) Scrt1 Mus musculus (Mouse) TR37362_c2_g2_i3 Q3ZTK5 TNR5_HORSE 5.00E-06 GO:0042113; GO:0035631; GO:0006874; GO:0071260; GO:0051607; GO:0009897; GO:0002768; GO:0043231; GO:0030890; GO:0043089; GO:0043123; GO:0043406; GO:0051092; GO:0032855; GO:2000353; GO:0032735; GO:0048304; GO:0090037; GO:0045944; GO:0042511; GO:0051023 B cell activation; CD40 receptor complex; cellular calcium ion homeostasis; cellular response to mechanical stimulus; defense response to virus; external side of plasma membrane; immune response-regulating cell surface receptor signaling pathway; intracellular membrane-bounded organelle; positive regulation of B cell proliferation; positive regulation of Cdc42 GTPase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAP kinase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of Rac GTPase activity; positive regulation of endothelial cell apoptotic process; positive regulation of interleukin-12 production; positive regulation of isotype switching to IgG isotypes; positive regulation of protein kinase C signaling cascade; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of immunoglobulin secretion IPR001368; IPR020435; Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (CD40L receptor) (CD antigen CD40) CD40 TNFRSF5 Equus caballus (Horse) TR37363_c0_g3_i1 A7RR34 U740_NEMVE 1.00E-27 UPF0740 protein v1g200856 v1g200856 Nematostella vectensis (Starlet sea anemone) TR37366_c0_g2_i1 Q9Z200 SH2B2_RAT 9.00E-61 GO:0001922; GO:0030036; GO:0005884; GO:0050851; GO:0050873; GO:0019221; GO:0005737; GO:0008286; GO:0035556; GO:0016020; GO:0007399; GO:0005543; GO:0046578; GO:0019222; GO:0001726; GO:0004871; GO:0001725 Itself B-1 B cell homeostasis; actin cytoskeleton organization; actin filament; antigen receptor-mediated signaling pathway; brown fat cell differentiation; cytokine-mediated signaling pathway; cytoplasm; insulin receptor signaling pathway; intracellular signal transduction; membrane; nervous system development; phospholipid binding; regulation of Ras protein signal transduction; regulation of metabolic process; ruffle; signal transducer activity; stress fiber IPR011993; IPR015012; IPR001849; IPR000980; SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS) Sh2b2 Aps Rattus norvegicus (Rat) TR37367_c0_g4_i4 O15374 MOT5_HUMAN 5.00E-22 GO:0005887; GO:0008028; GO:0015293 integral to plasma membrane; monocarboxylic acid transmembrane transporter activity; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 5 (MCT 5) (Monocarboxylate transporter 4) (MCT 4) (Solute carrier family 16 member 4) SLC16A4 MCT4 MCT5 Homo sapiens (Human) TR37367_c0_g4_i5 Q66HE2 MOT13_RAT 3.00E-27 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 13 (MCT 13) (Solute carrier family 16 member 13) Slc16a13 Mct13 Rattus norvegicus (Rat) TR37368_c1_g2_i1 Q06547 GABP1_HUMAN 1.00E-74 GO:0005634; GO:0045944; GO:0046982; GO:0003700; GO:0044212; GO:0006351 Q8CGM1; P51610; Q96M61 "nucleus; positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR002110; IPR020683; GA-binding protein subunit beta-1 (GABP subunit beta-1) (GABPB-1) (GABP subunit beta-2) (GABPB-2) (Nuclear respiratory factor 2) (Transcription factor E4TF1-47) (Transcription factor E4TF1-53) GABPB1 E4TF1B GABPB GABPB2 Homo sapiens (Human) TR37371_c3_g4_i2 Q561R0 PERP1_RAT 3.00E-30 GO:0034663; GO:0005788; GO:0005576; GO:0033622; GO:2001274; GO:0008284; GO:0002642; GO:0030888 endoplasmic reticulum chaperone complex; endoplasmic reticulum lumen; extracellular region; integrin activation; negative regulation of glucose import in response to insulin stimulus; positive regulation of cell proliferation; positive regulation of immunoglobulin biosynthetic process; regulation of B cell proliferation IPR021852; Marginal zone B- and B1-cell-specific protein (Plasma cell-induced resident endoplasmic reticulum protein) (Plasma cell-induced resident ER protein) (pERp1) (Proapoptotic caspase adapter protein) Mzb1 Pacap Rattus norvegicus (Rat) TR37372_c2_g2_i2 Q61066 NR0B1_MOUSE 5.00E-17 GO:0032448; GO:0033327; GO:0003723; GO:0060008; GO:0030325; GO:0004879; GO:0030238; GO:0016020; GO:0045596; GO:0033144; GO:0043433; GO:0000122; GO:0005634; GO:0042788; GO:0008104; GO:0035902; GO:0043565; GO:0007283; GO:0006694; GO:0003707; GO:0003714 Q61539; Q80Z64; P20263; Q6PR54; P70414 DNA hairpin binding; Leydig cell differentiation; RNA binding; Sertoli cell differentiation; adrenal gland development; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; male sex determination; membrane; negative regulation of cell differentiation; negative regulation of intracellular steroid hormone receptor signaling pathway; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; nucleus; polysomal ribosome; protein localization; response to immobilization stress; sequence-specific DNA binding; spermatogenesis; steroid biosynthetic process; steroid hormone receptor activity; transcription corepressor activity IPR008946; IPR000536; IPR025900; IPR001723; Nuclear receptor subfamily 0 group B member 1 (Nuclear receptor DAX-1) Nr0b1 Ahch Dax1 Mus musculus (Mouse) TR37372_c2_g2_i3 Q61066 NR0B1_MOUSE 6.00E-17 GO:0032448; GO:0033327; GO:0003723; GO:0060008; GO:0030325; GO:0004879; GO:0030238; GO:0016020; GO:0045596; GO:0033144; GO:0043433; GO:0000122; GO:0005634; GO:0042788; GO:0008104; GO:0035902; GO:0043565; GO:0007283; GO:0006694; GO:0003707; GO:0003714 Q61539; Q80Z64; P20263; Q6PR54; P70414 DNA hairpin binding; Leydig cell differentiation; RNA binding; Sertoli cell differentiation; adrenal gland development; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; male sex determination; membrane; negative regulation of cell differentiation; negative regulation of intracellular steroid hormone receptor signaling pathway; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; nucleus; polysomal ribosome; protein localization; response to immobilization stress; sequence-specific DNA binding; spermatogenesis; steroid biosynthetic process; steroid hormone receptor activity; transcription corepressor activity IPR008946; IPR000536; IPR025900; IPR001723; Nuclear receptor subfamily 0 group B member 1 (Nuclear receptor DAX-1) Nr0b1 Ahch Dax1 Mus musculus (Mouse) TR37372_c3_g1_i1 Q95SX7 RTBS_DROME 1.00E-32 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR37373_c1_g2_i6 Q4FZT2 PPME1_RAT 9.00E-13 GO:0004091; GO:0051722; GO:0006482; GO:0008601; GO:0002028 carboxylesterase activity; protein C-terminal methylesterase activity; protein demethylation; protein phosphatase type 2A regulator activity; regulation of sodium ion transport IPR016812; Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) Ppme1 Pme1 Rattus norvegicus (Rat) TR37374_c0_g1_i1 Q5RKI3 DPOLL_RAT 2.00E-155 GO:0003677; GO:0006260; GO:0003887; GO:0016829; GO:0046872; GO:0006289; GO:0005634 DNA binding; DNA replication; DNA-directed DNA polymerase activity; lyase activity; metal ion binding; nucleotide-excision repair; nucleus IPR001357; IPR002054; IPR019843; IPR010996; IPR028207; IPR018944; IPR022312; IPR002008; IPR027421; IPR003583; DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) Poll Rattus norvegicus (Rat) TR37374_c0_g1_i2 Q9NP87 DPOLM_HUMAN 9.00E-33 GO:0030183; GO:0003677; GO:0006310; GO:0006281; GO:0003887; GO:0046872; GO:0005634; GO:0016446 B cell differentiation; DNA binding; DNA recombination; DNA repair; DNA-directed DNA polymerase activity; metal ion binding; nucleus; somatic hypermutation of immunoglobulin genes IPR001357; IPR002054; IPR027249; IPR019843; IPR010996; IPR028207; IPR018944; IPR022312; IPR027421; IPR001726; DNA-directed DNA/RNA polymerase mu (Pol Mu) (EC 2.7.7.7) (Terminal transferase) POLM polmu Homo sapiens (Human) TR37374_c0_g1_i9 Q5RKI3 DPOLL_RAT 1.00E-155 GO:0003677; GO:0006260; GO:0003887; GO:0016829; GO:0046872; GO:0006289; GO:0005634 DNA binding; DNA replication; DNA-directed DNA polymerase activity; lyase activity; metal ion binding; nucleotide-excision repair; nucleus IPR001357; IPR002054; IPR019843; IPR010996; IPR028207; IPR018944; IPR022312; IPR002008; IPR027421; IPR003583; DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) Poll Rattus norvegicus (Rat) TR37375_c0_g1_i1 Q8NCE2 MTMRE_HUMAN 4.00E-136 GO:0005829; GO:0035335; GO:0048471; GO:0006661; GO:0004438; GO:0004725; GO:0001726; GO:0044281 cytosol; peptidyl-tyrosine dephosphorylation; perinuclear region of cytoplasm; phosphatidylinositol biosynthetic process; phosphatidylinositol-3-phosphatase activity; protein tyrosine phosphatase activity; ruffle; small molecule metabolic process IPR016130 Myotubularin-related protein 14 (EC 3.1.3.-) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (hJumpy) MTMR14 C3orf29 Homo sapiens (Human) TR37375_c0_g1_i5 Q8NCE2 MTMRE_HUMAN 3.00E-128 GO:0005829; GO:0035335; GO:0048471; GO:0006661; GO:0004438; GO:0004725; GO:0001726; GO:0044281 cytosol; peptidyl-tyrosine dephosphorylation; perinuclear region of cytoplasm; phosphatidylinositol biosynthetic process; phosphatidylinositol-3-phosphatase activity; protein tyrosine phosphatase activity; ruffle; small molecule metabolic process IPR016130 Myotubularin-related protein 14 (EC 3.1.3.-) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (hJumpy) MTMR14 C3orf29 Homo sapiens (Human) TR37377_c3_g1_i1 Q14790 CASP8_HUMAN 4.00E-25 GO:0031265; GO:0030690; GO:0035666; GO:0006919; GO:0001525; GO:0044297; GO:0006921; GO:0071260; GO:0005813; GO:0097153; GO:0005829; GO:0031264; GO:0097191; GO:0007507; GO:0045087; GO:0097193; GO:0030225; GO:0045121; GO:0005741; GO:0019048; GO:0043124; GO:0001841; GO:0043005; GO:0070423; GO:0005634; GO:0043123; GO:0045651; GO:1900740; GO:0045862; GO:0051291; GO:0051603; GO:2001239; GO:0046677; GO:0032025; GO:0009409; GO:0032355; GO:0045471; GO:0032496; GO:0034612; GO:0097342; GO:0034138; GO:0034142 P51572; Q92851; Q9UKL3; O15519-1; Q13618; Q13158; P25445; P48023; Q13418; Q9UDY8; O60936; P29350; Q13546; O00220 CD95 death-inducing signaling complex; Noc1p-Noc2p complex; TRIF-dependent toll-like receptor signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cell body; cellular component disassembly involved in execution phase of apoptosis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; cytosol; death-inducing signaling complex; extrinsic apoptotic signaling pathway; heart development; innate immune response; intrinsic apoptotic signaling pathway; macrophage differentiation; membrane raft; mitochondrial outer membrane; modulation by virus of host morphology or physiology; negative regulation of I-kappaB kinase/NF-kappaB cascade; neural tube formation; neuron projection; nucleotide-binding oligomerization domain containing signaling pathway; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macrophage differentiation; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of proteolysis; protein heterooligomerization; proteolysis involved in cellular protein catabolic process; regulation of extrinsic apoptotic signaling pathway in absence of ligand; response to antibiotic; response to cobalt ion; response to cold; response to estradiol stimulus; response to ethanol; response to lipopolysaccharide; response to tumor necrosis factor; ripoptosome; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] CASP8 MCH5 Homo sapiens (Human) TR37379_c3_g1_i1 Q6P4S8 INT1_MOUSE 0 GO:0034474; GO:0001833; GO:0016021; GO:0032039; GO:0043066; GO:0043154; GO:0031965; GO:0005634 U2 snRNA 3'-end processing; inner cell mass cell proliferation; integral to membrane; integrator complex; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; nuclear membrane; nucleus IPR016024; IPR022145; Integrator complex subunit 1 (Int1) Ints1 Mus musculus (Mouse) TR37379_c4_g1_i1 Q6P4S8 INT1_MOUSE 8.00E-51 GO:0034474; GO:0001833; GO:0016021; GO:0032039; GO:0043066; GO:0043154; GO:0031965; GO:0005634 U2 snRNA 3'-end processing; inner cell mass cell proliferation; integral to membrane; integrator complex; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; nuclear membrane; nucleus IPR016024; IPR022145; Integrator complex subunit 1 (Int1) Ints1 Mus musculus (Mouse) TR37380_c1_g1_i1 Q3MHZ8 LEG9_BOVIN 4.00E-17 GO:0030246; GO:0005737; GO:0005576 carbohydrate binding; cytoplasm; extracellular region IPR008985; IPR013320; IPR001079; Galectin-9 (Gal-9) LGALS9 Bos taurus (Bovine) TR37380_c1_g2_i1 P36573 LEC1_CAEEL 4.00E-34 GO:0030246; GO:0060102; GO:0016936 carbohydrate binding; collagen and cuticulin-based cuticle extracellular matrix; galactoside binding IPR008985; IPR013320; IPR001079; 32 kDa beta-galactoside-binding lectin (32 kDa GBP) lec-1 W09H1.6 Caenorhabditis elegans TR37380_c1_g2_i2 Q8K419 LEG4_MOUSE 2.00E-24 GO:0030246 carbohydrate binding IPR008985; IPR013320; IPR015533; IPR001079; Galectin-4 (Gal-4) (Lactose-binding lectin 4) Lgals4 Mus musculus (Mouse) TR37381_c2_g1_i1 P46493 ILVA_HAEIN 1.00E-51 GO:0004794; GO:0009097; GO:0030170; GO:0006566 L-threonine ammonia-lyase activity; isoleucine biosynthetic process; pyridoxal phosphate binding; threonine metabolic process IPR000634; IPR005787; IPR001721; IPR001926; Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1. L-threonine dehydratase biosynthetic IlvA (EC 4.3.1.19) (Threonine deaminase) ilvA HI_0738.1 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) TR37381_c2_g1_i3 Q7A5L8 TDCB_STAAN 4.00E-59 GO:0004794; GO:0070689; GO:0000166; GO:0030170 L-threonine ammonia-lyase activity; L-threonine catabolic process to propionate; nucleotide binding; pyridoxal phosphate binding IPR000634; IPR005789; IPR001926; Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine: step 1/4. L-threonine dehydratase catabolic TdcB (EC 4.3.1.19) (Threonine deaminase) tdcB SA1271 Staphylococcus aureus (strain N315) TR37382_c0_g1_i2 Q3ZBY7 DEGS1_BOVIN 6.00E-135 GO:0005789; GO:0006633; GO:0016021; GO:0005739; GO:0016705 "endoplasmic reticulum membrane; fatty acid biosynthetic process; integral to membrane; mitochondrion; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR005804; IPR011388; IPR013866; Sphingolipid delta(4)-desaturase DES1 (EC 1.14.-.-) (Degenerative spermatocyte homolog 1) DEGS1 DES1 Bos taurus (Bovine) TR37384_c6_g3_i2 O35608 ANGP2_MOUSE 4.00E-40 GO:0048014; GO:0001525; GO:0001974; GO:0042995; GO:0071363; GO:0007492; GO:0005615; GO:0007281; GO:0072012; GO:0030097; GO:0060135; GO:0046872; GO:0016525; GO:0043537; GO:0010812; GO:0050928; GO:0005634; GO:0031100; GO:0005886; GO:0045766; GO:0014823; GO:0009749; GO:0001666; GO:0009612; GO:0014070; GO:0009314; GO:0005172 Tie signaling pathway; angiogenesis; blood vessel remodeling; cell projection; cellular response to growth factor stimulus; endoderm development; extracellular space; germ cell development; glomerulus vasculature development; hemopoiesis; maternal process involved in female pregnancy; metal ion binding; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of cell-substrate adhesion; negative regulation of positive chemotaxis; nucleus; organ regeneration; plasma membrane; positive regulation of angiogenesis; response to activity; response to glucose stimulus; response to hypoxia; response to mechanical stimulus; response to organic cyclic compound; response to radiation; vascular endothelial growth factor receptor binding IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-2 (ANG-2) Angpt2 Agpt2 Mus musculus (Mouse) TR37384_c6_g3_i4 D8VNT0 FCNV4_CERRY 9.00E-47 GO:0005576 extracellular region IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ryncolin-4 Cerberus rynchops (Dog-faced water snake) TR37384_c6_g3_i5 Q9U8W7 TL5B_TACTR 1.00E-34 GO:0030246; GO:0016337; GO:0005576; GO:0046872 carbohydrate binding; cell-cell adhesion; extracellular region; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Techylectin-5B Tachypleus tridentatus (Japanese horseshoe crab) TR37384_c6_g3_i7 Q00546 TENR_CHICK 2.00E-42 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR013032; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin-R (TN-R) (Restrictin) TNR Gallus gallus (Chicken) TR37385_c0_g1_i1 Q66J85 ZFAN3_XENLA 4.00E-31 GO:0003677; GO:0008270 DNA binding; zinc ion binding IPR002653; IPR000058; AN1-type zinc finger protein 3 homolog zfand3 Xenopus laevis (African clawed frog) TR37387_c1_g1_i1 Q8BLY1 SMOC1_MOUSE 6.00E-33 GO:0005604; GO:0005509; GO:0030154; GO:0050840; GO:0030198; GO:0001654; GO:0060173; GO:0010811; GO:0007165 basement membrane; calcium ion binding; cell differentiation; extracellular matrix binding; extracellular matrix organization; eye development; limb development; positive regulation of cell-substrate adhesion; signal transduction IPR011992; IPR018247; IPR002350; IPR019577; IPR000716; SPARC-related modular calcium-binding protein 1 (SPARC-related gene protein) (Secreted modular calcium-binding protein 1) (SMOC-1) Smoc1 Srg Mus musculus (Mouse) TR37387_c1_g1_i2 P10493 NID1_MOUSE 2.00E-10 GO:0005605; GO:0005509; GO:0071944; GO:0007160; GO:0005518; GO:0032836; GO:0043237; GO:0010811 basal lamina; calcium ion binding; cell periphery; cell-matrix adhesion; collagen binding; glomerular basement membrane development; laminin-1 binding; positive regulation of cell-substrate adhesion IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR006605; IPR009017; IPR023413; IPR009030; IPR000033; IPR003886; IPR000716; Nidogen-1 (NID-1) (Entactin) Nid1 Ent Mus musculus (Mouse) TR37387_c1_g1_i3 P06882 THYG_RAT 3.00E-08 GO:0005794; GO:0005783; GO:0005615; GO:0042446; GO:0048471; GO:0043234; GO:0042803; GO:0032496; GO:0009268; GO:0006590; GO:0045056 P06761; P38659 Golgi apparatus; endoplasmic reticulum; extracellular space; hormone biosynthetic process; perinuclear region of cytoplasm; protein complex; protein homodimerization activity; response to lipopolysaccharide; response to pH; thyroid hormone generation; transcytosis IPR002018; IPR019819; IPR016324; IPR000716; IPR011641; Thyroglobulin (Tg) Tg Rattus norvegicus (Rat) TR37388_c0_g1_i1 O74501 YCRE_SCHPO 1.00E-06 GO:0006888; GO:0030008; GO:0005801; GO:0005829; GO:0006886; GO:0005634; GO:0032313 ER to Golgi vesicle-mediated transport; TRAPP complex; cis-Golgi network; cytosol; intracellular protein transport; nucleus; regulation of Rab GTPase activity Uncharacterized protein CC285.14 SPCC285.14 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR37388_c0_g2_i1 P48553 TPC10_HUMAN 2.00E-111 GO:0005794; GO:0016021; GO:0015081; GO:0016192 Q96QF0 Golgi apparatus; integral to membrane; sodium ion transmembrane transporter activity; vesicle-mediated transport IPR022233; Trafficking protein particle complex subunit 10 (Epilepsy holoprosencephaly candidate 1 protein) (EHOC-1) (Protein GT334) (Trafficking protein particle complex subunit TMEM1) (Transport protein particle subunit TMEM1) (TRAPP subunit TMEM1) TRAPPC10 EHOC1 TMEM1 Homo sapiens (Human) TR37388_c0_g2_i3 P48553 TPC10_HUMAN 9.00E-45 GO:0005794; GO:0016021; GO:0015081; GO:0016192 Q96QF0 Golgi apparatus; integral to membrane; sodium ion transmembrane transporter activity; vesicle-mediated transport IPR022233; Trafficking protein particle complex subunit 10 (Epilepsy holoprosencephaly candidate 1 protein) (EHOC-1) (Protein GT334) (Trafficking protein particle complex subunit TMEM1) (Transport protein particle subunit TMEM1) (TRAPP subunit TMEM1) TRAPPC10 EHOC1 TMEM1 Homo sapiens (Human) TR37389_c0_g1_i3 P86854 PLCL_MYTGA 5.00E-09 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR37389_c0_g1_i4 Q8HY04 CD209_PAPHA 2.00E-10 GO:0007155; GO:0006897; GO:0045087; GO:0016021; GO:0005537; GO:0046872 cell adhesion; endocytosis; innate immune response; integral to membrane; mannose binding; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; CD209 antigen (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN1) (CD antigen CD209) CD209 Papio hamadryas (Hamadryas baboon) TR37389_c0_g1_i5 P02707 LECH_CHICK 2.00E-07 GO:0030246; GO:0006897; GO:0016021 carbohydrate binding; endocytosis; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; Hepatic lectin Gallus gallus (Chicken) TR37389_c0_g1_i6 Q90953 CSPG2_CHICK 1.00E-08 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Gallus gallus (Chicken) TR37389_c0_g1_i7 Q66S03 NATTE_THANI 6.00E-10 GO:0030246; GO:0005576; GO:0006954; GO:0046872 carbohydrate binding; extracellular region; inflammatory response; metal ion binding IPR001304; IPR016186; IPR016187; Galactose-specific lectin nattectin (CTL) Thalassophryne nattereri (Niquim) TR37390_c2_g1_i2 Q8N8A6 DDX51_HUMAN 6.00E-164 GO:0005524; GO:0008026; GO:0003723; GO:0005730; GO:0006364 ATP binding; ATP-dependent helicase activity; RNA binding; nucleolus; rRNA processing IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; ATP-dependent RNA helicase DDX51 (EC 3.6.4.13) (DEAD box protein 51) DDX51 Homo sapiens (Human) TR37392_c5_g1_i1 Q2TBA3 MALT1_MOUSE 4.00E-21 GO:0001923; GO:0042098; GO:0050852; GO:0007250; GO:0004197; GO:0005829; GO:0045087; GO:0019209; GO:0051168; GO:0005634; GO:0048471; GO:0043123; GO:0051092; GO:0050870; GO:0002726; GO:0032743; GO:0043234; GO:0051259; GO:0006508; GO:0050856; GO:0042981; GO:0009620; GO:0002237; GO:0004871; GO:0004842 B-1 B cell differentiation; T cell proliferation; T cell receptor signaling pathway; activation of NF-kappaB-inducing kinase activity; cysteine-type endopeptidase activity; cytosol; innate immune response; kinase activator activity; nuclear export; nucleus; perinuclear region of cytoplasm; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell activation; positive regulation of T cell cytokine production; positive regulation of interleukin-2 production; protein complex; protein oligomerization; proteolysis; regulation of T cell receptor signaling pathway; regulation of apoptotic process; response to fungus; response to molecule of bacterial origin; signal transducer activity; ubiquitin-protein ligase activity IPR011029; IPR007110; IPR013783; IPR003598; IPR011600; IPR001309; Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog (EC 3.4.22.-) (Paracaspase) Malt1 Mus musculus (Mouse) TR37392_c6_g4_i1 Q9UDY8 MALT1_HUMAN 2.00E-20 GO:0001923; GO:0032449; GO:0038095; GO:0042098; GO:0050852; GO:0007250; GO:0004197; GO:0005829; GO:0045087; GO:0043066; GO:0051168; GO:0005634; GO:0048471; GO:0005886; GO:0043123; GO:0051092; GO:0050870; GO:0002726; GO:0032743; GO:0031398; GO:0051259; GO:0006508; GO:0050856; GO:0009620; GO:0002237; GO:0004871; GO:0004842 O95999; Q14790; Q9Y6K9; Q13501; Q9Y4K3; P0CG48 B-1 B cell differentiation; CBM complex; Fc-epsilon receptor signaling pathway; T cell proliferation; T cell receptor signaling pathway; activation of NF-kappaB-inducing kinase activity; cysteine-type endopeptidase activity; cytosol; innate immune response; negative regulation of apoptotic process; nuclear export; nucleus; perinuclear region of cytoplasm; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell activation; positive regulation of T cell cytokine production; positive regulation of interleukin-2 production; positive regulation of protein ubiquitination; protein oligomerization; proteolysis; regulation of T cell receptor signaling pathway; response to fungus; response to molecule of bacterial origin; signal transducer activity; ubiquitin-protein ligase activity IPR011029; IPR007110; IPR013783; IPR003599; IPR003598; IPR011600; IPR001309; Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase) MALT1 MLT Homo sapiens (Human) TR37393_c3_g2_i1 O54862 MBTP2_CRIGR 1.00E-135 GO:0008203; GO:0005737; GO:0016021; GO:0046872; GO:0004222; GO:0006508 cholesterol metabolic process; cytoplasm; integral to membrane; metal ion binding; metalloendopeptidase activity; proteolysis IPR001193; IPR001478; IPR008915; Membrane-bound transcription factor site-2 protease (EC 3.4.24.85) (Endopeptidase S2P) (Sterol regulatory element-binding proteins intramembrane protease) (SREBPs intramembrane protease) MBTPS2 S2P Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR37397_c0_g1_i1 Q9DB05 SNAA_MOUSE 2.00E-129 GO:0035494; GO:0045176; GO:0007420; GO:0006886; GO:0030182; GO:0010807; GO:0035249; GO:0070044; GO:0019905 "SNARE complex disassembly; apical protein localization; brain development; intracellular protein transport; neuron differentiation; regulation of synaptic vesicle priming; synaptic transmission, glutamatergic; synaptobrevin 2-SNAP-25-syntaxin-1a complex; syntaxin binding" IPR000744; IPR011990; Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) Napa Snapa Mus musculus (Mouse) TR37397_c0_g3_i1 P28663 SNAB_MOUSE 1.00E-124 GO:0035494; GO:0006886; GO:0010807; GO:0035249; GO:0070044; GO:0019905 "SNARE complex disassembly; intracellular protein transport; regulation of synaptic vesicle priming; synaptic transmission, glutamatergic; synaptobrevin 2-SNAP-25-syntaxin-1a complex; syntaxin binding" IPR000744; IPR011990; Beta-soluble NSF attachment protein (SNAP-beta) (Brain protein I47) (N-ethylmaleimide-sensitive factor attachment protein beta) Napb Snapb Mus musculus (Mouse) TR37398_c0_g1_i1 Q90773 CEPU1_CHICK 2.00E-28 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Protein CEPU-1 Gallus gallus (Chicken) TR37398_c0_g1_i2 Q5IS61 OPCM_PANTR 4.00E-15 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) OPCML OBCAM Pan troglodytes (Chimpanzee) TR37398_c0_g1_i3 P15364 AMAL_DROME 5.00E-21 GO:0031225; GO:0005886 anchored to membrane; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Protein amalgam Ama CG2198 Drosophila melanogaster (Fruit fly) TR37400_c1_g6_i2 Q53G44 IF44L_HUMAN 3.00E-51 GO:0005737; GO:0051607; GO:0006955 cytoplasm; defense response to virus; immune response IPR024644; IPR027417; Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) TR37400_c1_g6_i3 Q8TCB0 IFI44_HUMAN 5.00E-46 GO:0005737; GO:0009615 cytoplasm; response to virus IPR024644; IPR027417; IPR006571; Interferon-induced protein 44 (p44) (Microtubule-associated protein 44) IFI44 MTAP44 Homo sapiens (Human) TR37400_c1_g6_i7 Q53G44 IF44L_HUMAN 1.00E-51 GO:0005737; GO:0051607; GO:0006955 cytoplasm; defense response to virus; immune response IPR024644; IPR027417; Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) TR37401_c1_g1_i2 Q9UPR0 PLCL2_HUMAN 0 GO:0005509; GO:0005737; GO:0035556; GO:0006629; GO:0004435; GO:0005543; GO:0004871 calcium ion binding; cytoplasm; intracellular signal transduction; lipid metabolic process; phosphatidylinositol phospholipase C activity; phospholipid binding; signal transducer activity IPR000008; IPR011992; IPR011993; IPR001192; IPR017946; IPR001849; IPR015359; IPR000909; IPR001711; Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2) PLCL2 KIAA1092 PLCE2 Homo sapiens (Human) TR37402_c3_g2_i1 Q09GK0 CLECB_PHIOL 9.00E-08 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Snaclec subunit B (C-type lectin subunit B) Philodryas olfersii (Green snake) TR37402_c3_g5_i1 P10716 CLC4F_RAT 6.00E-18 GO:0030246; GO:0006897; GO:0016021; GO:0004872 carbohydrate binding; endocytosis; integral to membrane; receptor activity IPR001304; IPR016186; IPR018378; IPR016187; C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13) (Kupffer cell receptor) Clec4f Clecsf13 Kclr Rattus norvegicus (Rat) TR37402_c3_g5_i2 P02707 LECH_CHICK 1.00E-13 GO:0030246; GO:0006897; GO:0016021 carbohydrate binding; endocytosis; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; Hepatic lectin Gallus gallus (Chicken) TR37402_c3_g5_i3 Q5M9I1 CL2DR_RAT 9.00E-06 GO:0030246; GO:0016021; GO:0005886 carbohydrate binding; integral to membrane; plasma membrane IPR001304; IPR016186; IPR016187; C-type lectin domain family 2 member D-related protein Rattus norvegicus (Rat) TR37402_c3_g6_i1 P70194 CLC4F_MOUSE 9.00E-11 GO:0030246; GO:0006897; GO:0016021 carbohydrate binding; endocytosis; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13) (Kupffer cell receptor) Clec4f Clecsf13 Kclr Mus musculus (Mouse) TR37402_c3_g6_i5 P86854 PLCL_MYTGA 1.00E-17 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR37405_c1_g1_i3 O95563 MPC2_HUMAN 1.00E-39 GO:0016021; GO:0005743; GO:0006850; GO:0005739; GO:0006090; GO:0050833 integral to membrane; mitochondrial inner membrane; mitochondrial pyruvate transport; mitochondrion; pyruvate metabolic process; pyruvate transmembrane transporter activity IPR005336; Mitochondrial pyruvate carrier 2 (Brain protein 44) MPC2 BRP44 Homo sapiens (Human) TR37406_c2_g1_i10 Q76CA2 ACTP2_CYMEC 2.00E-31 GO:0019835; GO:0044179; GO:0016021; GO:0006811; GO:0044218 cytolysis; hemolysis in other organism; integral to membrane; ion transport; other organism cell membrane IPR015926; Echotoxin-2 (Echt 2) Cymatium echo (Giant triton) (Monoplex echo) TR37406_c2_g1_i8 Q76CA2 ACTP2_CYMEC 2.00E-33 GO:0019835; GO:0044179; GO:0016021; GO:0006811; GO:0044218 cytolysis; hemolysis in other organism; integral to membrane; ion transport; other organism cell membrane IPR015926; Echotoxin-2 (Echt 2) Cymatium echo (Giant triton) (Monoplex echo) TR37408_c4_g1_i1 Q86VR2 F134C_HUMAN 1.00E-50 GO:0016021 integral to membrane Protein FAM134C FAM134C Homo sapiens (Human) TR37409_c1_g1_i3 P42781 XPR6_YARLI 5.00E-17 GO:0016021; GO:0006508; GO:0004252 integral to membrane; proteolysis; serine-type endopeptidase activity IPR008979; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR002884; Dibasic-processing endoprotease (EC 3.4.21.-) XPR6 YALI0F13189g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR37409_c2_g2_i1 P41413 PCSK5_RAT 2.00E-35 GO:0005794; GO:0009952; GO:0042089; GO:0007566; GO:0048566; GO:0048706; GO:0012505; GO:0005615; GO:0007507; GO:0016021; GO:0001822; GO:0035108; GO:0042277; GO:0043043; GO:0016486; GO:0006508; GO:0002001; GO:0030323; GO:0030141; GO:0004252; GO:0006465 Golgi apparatus; anterior/posterior pattern specification; cytokine biosynthetic process; embryo implantation; embryonic digestive tract development; embryonic skeletal system development; endomembrane system; extracellular space; heart development; integral to membrane; kidney development; limb morphogenesis; peptide binding; peptide biosynthetic process; peptide hormone processing; proteolysis; renin secretion into blood stream; respiratory tube development; secretory granule; serine-type endopeptidase activity; signal peptide processing IPR000742; IPR006212; IPR008979; IPR009030; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (Subtilisin/kexin-like protease PC5) (rPC5) Pcsk5 Rattus norvegicus (Rat) TR37409_c3_g1_i1 P07996 TSP1_HUMAN 4.00E-09 GO:0000187; GO:0048266; GO:0005509; GO:0007155; GO:0007050; GO:0016477; GO:0034605; GO:0002544; GO:0070052; GO:0003197; GO:0043652; GO:0009897; GO:0031012; GO:0030198; GO:0070062; GO:0070051; GO:0005577; GO:0017134; GO:0001968; GO:0003417; GO:0008201; GO:0042802; GO:0006955; GO:0005178; GO:0043236; GO:0030169; GO:0016525; GO:0002581; GO:0043066; GO:0043537; GO:0010754; GO:0043154; GO:0002605; GO:0001937; GO:2001237; GO:0051918; GO:0040037; GO:0051895; GO:0032695; GO:0010751; GO:0010748; GO:0010757; GO:0003151; GO:0018149; GO:0001786; GO:0030168; GO:0031093; GO:0002576; GO:0045766; GO:0043536; GO:0010811; GO:2000353; GO:1900119; GO:1902043; GO:0010763; GO:0043032; GO:0010759; GO:0051897; GO:2000379; GO:0030511; GO:0032914; GO:0045727; GO:0042535; GO:0043394; GO:0051592; GO:0042493; GO:0034976; GO:0009749; GO:0001666; GO:0032026; GO:0032570; GO:0016529; GO:0002040; GO:0050431 P01137 activation of MAPK activity; behavioral response to pain; calcium ion binding; cell adhesion; cell cycle arrest; cell migration; cellular response to heat; chronic inflammatory response; collagen V binding; endocardial cushion development; engulfment of apoptotic cell; external side of plasma membrane; extracellular matrix; extracellular matrix organization; extracellular vesicular exosome; fibrinogen binding; fibrinogen complex; fibroblast growth factor binding; fibronectin binding; growth plate cartilage development; heparin binding; identical protein binding; immune response; integrin binding; laminin binding; low-density lipoprotein particle binding; negative regulation of angiogenesis; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; negative regulation of apoptotic process; negative regulation of blood vessel endothelial cell migration; negative regulation of cGMP-mediated signaling; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of dendritic cell antigen processing and presentation; negative regulation of endothelial cell proliferation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of fibrinolysis; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of focal adhesion assembly; negative regulation of interleukin-12 production; negative regulation of nitric oxide mediated signal transduction; negative regulation of plasma membrane long-chain fatty acid transport; negative regulation of plasminogen activation; outflow tract morphogenesis; peptide cross-linking; phosphatidylserine binding; platelet activation; platelet alpha granule lumen; platelet degranulation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell-substrate adhesion; positive regulation of endothelial cell apoptotic process; positive regulation of execution phase of apoptosis; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of fibroblast migration; positive regulation of macrophage activation; positive regulation of macrophage chemotaxis; positive regulation of protein kinase B signaling cascade; positive regulation of reactive oxygen species metabolic process; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of transforming growth factor beta1 production; positive regulation of translation; positive regulation of tumor necrosis factor biosynthetic process; proteoglycan binding; response to calcium ion; response to drug; response to endoplasmic reticulum stress; response to glucose stimulus; response to hypoxia; response to magnesium ion; response to progesterone stimulus; sarcoplasmic reticulum; sprouting angiogenesis; transforming growth factor beta binding IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR001791; IPR000884; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-1 THBS1 TSP TSP1 Homo sapiens (Human) TR37409_c3_g2_i1 Q5R7R7 THSD1_PONAB 5.00E-07 GO:0016021 integral to membrane IPR000884; Thrombospondin type-1 domain-containing protein 1 THSD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37409_c3_g3_i2 A7X4K1 WAP1_PHIOL 2.00E-07 GO:0042742; GO:0005576; GO:0010466; GO:0030414 defense response to bacterium; extracellular region; negative regulation of peptidase activity; peptidase inhibitor activity IPR008197; Waprin-Phi1 Philodryas olfersii (Green snake) TR3741_c0_g1_i1 P86858 MYT2_MYTCA 5.00E-83 GO:0005576 extracellular region Mytilin-2 (Mytilus uncharacterized protein 2) (MUSP-2) Mytilus californianus (California mussel) TR37410_c0_g1_i1 P41775 COX3_MYTED 2.00E-151 GO:0019646; GO:0004129; GO:0016021; GO:0005743 aerobic electron transport chain; cytochrome-c oxidase activity; integral to membrane; mitochondrial inner membrane IPR024791; IPR000298; IPR013833; Cytochrome c oxidase subunit 3 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide III) COIII Mytilus edulis (Blue mussel) TR37410_c1_g1_i1 P33511 NU4M_ANOQU 4.00E-37 GO:0008137; GO:0016021; GO:0006120; GO:0031966; GO:0070469 "NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial electron transport, NADH to ubiquinone; mitochondrial membrane; respiratory chain" IPR001750; IPR003918; IPR000260; NADH-ubiquinone oxidoreductase chain 4 (EC 1.6.5.3) (NADH dehydrogenase subunit 4) ND4 Anopheles quadrimaculatus (Common malaria mosquito) TR37410_c1_g1_i2 Q00231 NU4M_MYTED 9.00E-151 GO:0042773; GO:0008137; GO:0016021; GO:0031966; GO:0070469 ATP synthesis coupled electron transport; NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial membrane; respiratory chain IPR001750; IPR003918; NADH-ubiquinone oxidoreductase chain 4 (EC 1.6.5.3) (NADH dehydrogenase subunit 4) ND4 Mytilus edulis (Blue mussel) TR37411_c1_g1_i1 A0R5M8 EGTD_MYCS2 1.00E-24 GO:0052707; GO:0030745; GO:0052704; GO:0008276 "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine; dimethylhistidine N-methyltransferase activity; ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine; protein methyltransferase activity" IPR019257; IPR017804; Amino-acid biosynthesis; ergothioneine biosynthesis. Histidine-specific methyltransferase EgtD (EC 2.1.1.44) (Histidine-alpha-N-methyltransferase) egtD MSMEG_6247 MSMEI_6086 Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) TR37411_c1_g1_i4 O94632 MU158_SCHPO 1.00E-10 GO:0005509; GO:0005829; GO:0005788; GO:0007126; GO:0005634 calcium ion binding; cytosol; endoplasmic reticulum lumen; meiosis; nucleus IPR016187; IPR005532; IPR019257; IPR017805; Meiotically up-regulated gene 158 protein mug158 SPBC1604.01 SPBC1677.01c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR37411_c1_g1_i8 O69669 EGTD_MYCTU 5.00E-25 GO:0052707; GO:0030745; GO:0052704; GO:0005886; GO:0008276 "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine; dimethylhistidine N-methyltransferase activity; ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine; plasma membrane; protein methyltransferase activity" IPR019257; IPR017804; Amino-acid biosynthesis; ergothioneine biosynthesis. Histidine-specific methyltransferase EgtD (EC 2.1.1.44) (Histidine-alpha-N-methyltransferase) egtD Rv3701c MT3804 Mycobacterium tuberculosis TR37413_c1_g3_i2 Q6P6T4 EMAL2_RAT 0 GO:0003824; GO:0005737; GO:0008152; GO:0005874; GO:0008022; GO:0005102 catalytic activity; cytoplasm; metabolic process; microtubule; protein C-terminus binding; receptor binding IPR005108; IPR011047; IPR011041; IPR015943; IPR001680; IPR017986; Echinoderm microtubule-associated protein-like 2 (EMAP-2) Eml2 Emap2 Rattus norvegicus (Rat) TR37413_c1_g3_i5 Q6P6T4 EMAL2_RAT 0 GO:0003824; GO:0005737; GO:0008152; GO:0005874; GO:0008022; GO:0005102 catalytic activity; cytoplasm; metabolic process; microtubule; protein C-terminus binding; receptor binding IPR005108; IPR011047; IPR011041; IPR015943; IPR001680; IPR017986; Echinoderm microtubule-associated protein-like 2 (EMAP-2) Eml2 Emap2 Rattus norvegicus (Rat) TR37414_c3_g1_i1 Q9UKB3 DJC12_HUMAN 3.00E-38 IPR001623; DnaJ homolog subfamily C member 12 (J domain-containing protein 1) DNAJC12 JDP1 Homo sapiens (Human) TR37414_c3_g1_i3 Q9R022 DJC12_MOUSE 4.00E-37 IPR001623; DnaJ homolog subfamily C member 12 (J domain-containing protein 1) Dnajc12 Jdp1 Mus musculus (Mouse) TR37414_c5_g2_i1 P56974 NRG2_MOUSE 6.00E-07 GO:0009790; GO:0005576; GO:0016021; GO:0005886 embryo development; extracellular region; integral to membrane; plasma membrane IPR000742; IPR013032; IPR007110; IPR013783; IPR013098; IPR003598; IPR002154; "Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2) [Cleaved into: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)]" Nrg2 Mus musculus (Mouse) TR37415_c0_g1_i2 Q9JMF7 DOPP1_MOUSE 2.00E-78 GO:0047874; GO:0030176; GO:0006487 dolichyldiphosphatase activity; integral to endoplasmic reticulum membrane; protein N-linked glycosylation IPR000326; Protein modification; protein glycosylation. Dolichyldiphosphatase 1 (EC 3.6.1.43) (Dolichyl pyrophosphate phosphatase 1) (Protein 2-23) Dolpp1 Mus musculus (Mouse) TR37416_c0_g4_i1 Q9HAB8 PPCS_HUMAN 5.00E-88 GO:0015937; GO:0005829; GO:0015939; GO:0004632 coenzyme A biosynthetic process; cytosol; pantothenate metabolic process; phosphopantothenate--cysteine ligase activity IPR007085; Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5. Phosphopantothenate--cysteine ligase (EC 6.3.2.5) (Phosphopantothenoylcysteine synthetase) (PPC synthetase) PPCS COAB Homo sapiens (Human) TR37416_c0_g4_i2 Q9LZM3 PPCS2_ARATH 6.00E-66 GO:0015937; GO:0004632 coenzyme A biosynthetic process; phosphopantothenate--cysteine ligase activity IPR007085; Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5. Phosphopantothenate--cysteine ligase 2 (EC 6.3.2.5) (Phosphopantothenoylcysteine synthetase 2) (PPC synthetase 2) PPCS2 COAB2 At5g02080 T7H20.130 Arabidopsis thaliana (Mouse-ear cress) TR37419_c0_g1_i1 Q6PIP5 NUDC1_MOUSE 5.00E-135 GO:0005737; GO:0005634 cytoplasm; nucleus IPR007052; IPR008978; NudC domain-containing protein 1 Nudcd1 Mus musculus (Mouse) TR37419_c0_g1_i2 Q96RS6 NUDC1_HUMAN 3.00E-18 GO:0005737; GO:0005634 cytoplasm; nucleus IPR007052; IPR008978; NudC domain-containing protein 1 (Chronic myelogenous leukemia tumor antigen 66) (Tumor antigen CML66) NUDCD1 CML66 Homo sapiens (Human) TR37420_c1_g1_i1 Q3SWZ4 EXOS9_BOVIN 1.00E-141 GO:0003723; GO:0005737; GO:0000178; GO:0005730; GO:0006364 RNA binding; cytoplasm; exosome (RNase complex); nucleolus; rRNA processing IPR001247; IPR015847; IPR020568; Exosome complex component RRP45 (Exosome component 9) EXOSC9 Bos taurus (Bovine) TR37423_c1_g1_i1 D3ZYR1 FCHO2_RAT 1.00E-52 GO:0048268; GO:0030136; GO:0072583; GO:0005905; GO:0010324; GO:0005546; GO:0001786; GO:0005886; GO:0072659 "clathrin coat assembly; clathrin-coated vesicle; clathrin-mediated endocytosis; coated pit; membrane invagination; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; plasma membrane; protein localization to plasma membrane" IPR001060; IPR018808; FCH domain only protein 2 Fcho2 Rattus norvegicus (Rat) TR37423_c3_g3_i2 Q0JRZ9 FCHO2_HUMAN 1.00E-94 GO:0048268; GO:0030136; GO:0072583; GO:0005905; GO:0010324; GO:0005546; GO:0001786; GO:0005886; GO:0072659 P98078; P42566 "clathrin coat assembly; clathrin-coated vesicle; clathrin-mediated endocytosis; coated pit; membrane invagination; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; plasma membrane; protein localization to plasma membrane" IPR001060; IPR018808; FCH domain only protein 2 FCHO2 Homo sapiens (Human) TR37425_c1_g1_i1 P76536 YFEX_ECOLI 7.00E-31 GO:0005737; GO:0020037; GO:0046872; GO:0004601 cytoplasm; heme binding; metal ion binding; peroxidase activity IPR011008; IPR006314; Probable deferrochelatase/peroxidase YfeX (EC 1.11.1.-) yfeX b2431 JW2424 Escherichia coli (strain K12) TR37426_c6_g1_i1 O76756 RS8_APIME 5.00E-94 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001047; IPR022309; IPR018283; 40S ribosomal protein S8 RpS8 Apis mellifera (Honeybee) TR37426_c6_g1_i2 Q4UFS9 RS8_THEAN 1.00E-63 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001047; IPR022309; IPR018283; 40S ribosomal protein S8 RPS8 TA16000 Theileria annulata TR37428_c0_g2_i3 P0DKQ8 ACTP_CONCN 7.00E-17 GO:0019835; GO:0044179; GO:0016021; GO:0006811; GO:0044218 cytolysis; hemolysis in other organism; integral to membrane; ion transport; other organism cell membrane IPR015926; Conoporin-Cn1 Conus consors (Singed cone) TR37428_c0_g2_i5 P0DKQ8 ACTP_CONCN 6.00E-17 GO:0019835; GO:0044179; GO:0016021; GO:0006811; GO:0044218 cytolysis; hemolysis in other organism; integral to membrane; ion transport; other organism cell membrane IPR015926; Conoporin-Cn1 Conus consors (Singed cone) TR37429_c0_g1_i1 A6NKF9 GPHRC_HUMAN 3.00E-147 GO:0016021 integral to membrane IPR025969; IPR022535; IPR015672; Putative Golgi pH regulator C (Protein GPR89C) GPR89C GPHRC Homo sapiens (Human) TR37429_c0_g1_i2 B5X1G3 GPHR_SALSA 0 GO:0000139; GO:0016021; GO:0015031; GO:0005244 Golgi membrane; integral to membrane; protein transport; voltage-gated ion channel activity IPR025969; IPR022535; IPR015672; Golgi pH regulator (Protein gpr89) gpr89 gphr Salmo salar (Atlantic salmon) TR37430_c3_g2_i1 Q9V9W8 PYGO_DROME 3.00E-38 GO:0016055; GO:0060232; GO:0048813; GO:0035214; GO:0048526; GO:0005634; GO:0030177; GO:0045944; GO:0007367; GO:0006351; GO:0008270 O00512; Q961D9 "Wnt receptor signaling pathway; delamination; dendrite morphogenesis; eye-antennal disc development; imaginal disc-derived wing expansion; nucleus; positive regulation of Wnt receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; segment polarity determination; transcription, DNA-dependent; zinc ion binding" IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Protein pygopus (Protein gammy legs) pygo gam CG11518 Drosophila melanogaster (Fruit fly) TR37432_c1_g2_i2 Q96LT7 CI072_HUMAN 1.00E-61 GO:0008219; GO:0005737; GO:0005634 cell death; cytoplasm; nucleus IPR027819; Protein C9orf72 C9orf72 Homo sapiens (Human) TR37432_c1_g2_i3 Q96LT7 CI072_HUMAN 7.00E-63 GO:0008219; GO:0005737; GO:0005634 cell death; cytoplasm; nucleus IPR027819; Protein C9orf72 C9orf72 Homo sapiens (Human) TR37434_c1_g2_i1 P25107 PTH1R_DIDVI 4.00E-81 GO:0007188; GO:0005887; GO:0004991; GO:0017046; GO:0043621 adenylate cyclase-modulating G-protein coupled receptor signaling pathway; integral to plasma membrane; parathyroid hormone receptor activity; peptide hormone binding; protein self-association IPR017981; IPR001879; IPR002170; IPR000832; IPR017983; Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) PTH1R PTHR PTHR1 Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) TR37434_c1_g2_i2 Q5RAQ1 PTH1R_PONAB 4.00E-76 GO:0007188; GO:0005887; GO:0004991; GO:0017046; GO:0043621 adenylate cyclase-modulating G-protein coupled receptor signaling pathway; integral to plasma membrane; parathyroid hormone receptor activity; peptide hormone binding; protein self-association IPR017981; IPR001879; IPR002170; IPR000832; IPR017983; Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) PTH1R PTHR1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37434_c1_g2_i3 Q8WN93 CALRL_PIG 6.00E-68 GO:0007189; GO:0001605; GO:0001525; GO:0006171; GO:0001635; GO:0004948; GO:0006816; GO:0071329; GO:0005783; GO:0005768; GO:0007507; GO:0016021; GO:0005764; GO:0005886; GO:0030819; GO:0048661; GO:0008565; GO:0031623 adenylate cyclase-activating G-protein coupled receptor signaling pathway; adrenomedullin receptor activity; angiogenesis; cAMP biosynthetic process; calcitonin gene-related polypeptide receptor activity; calcitonin receptor activity; calcium ion transport; cellular response to sucrose stimulus; endoplasmic reticulum; endosome; heart development; integral to membrane; lysosome; plasma membrane; positive regulation of cAMP biosynthetic process; positive regulation of smooth muscle cell proliferation; protein transporter activity; receptor internalization IPR003287; IPR017981; IPR003289; IPR001879; IPR000832; IPR017983; Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) CALCRL CGRPR Sus scrofa (Pig) TR37435_c1_g1_i1 Q92180 GCNT1_BOVIN 1.00E-51 GO:0031985; GO:0000139; GO:0003829; GO:0060352; GO:0009101; GO:0016021; GO:0050901; GO:0006486 "Golgi cisterna; Golgi membrane; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; cell adhesion molecule production; glycoprotein biosynthetic process; integral to membrane; leukocyte tethering or rolling; protein glycosylation" IPR003406; Protein modification; protein glycosylation. "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (Core 2-branching enzyme) (Core2-GlcNAc-transferase) (C2GNT) (Core 2 GNT)" GCNT1 Bos taurus (Bovine) TR37435_c1_g1_i3 Q92180 GCNT1_BOVIN 4.00E-52 GO:0031985; GO:0000139; GO:0003829; GO:0060352; GO:0009101; GO:0016021; GO:0050901; GO:0006486 "Golgi cisterna; Golgi membrane; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; cell adhesion molecule production; glycoprotein biosynthetic process; integral to membrane; leukocyte tethering or rolling; protein glycosylation" IPR003406; Protein modification; protein glycosylation. "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (Core 2-branching enzyme) (Core2-GlcNAc-transferase) (C2GNT) (Core 2 GNT)" GCNT1 Bos taurus (Bovine) TR37436_c0_g1_i1 Q7NJF7 GPMA2_GLOVI 4.00E-46 GO:0046538; GO:0006096 "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity; glycolysis" IPR013078; IPR001345; IPR005952; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2 (BPG-dependent PGAM 2) (PGAM 2) (Phosphoglyceromutase 2) (dPGM 2) (EC 5.4.2.11)" gpmA2 gll1875 Gloeobacter violaceus (strain PCC 7421) TR37436_c0_g1_i3 Q54NE6 PGAM_DICDI 9.00E-119 GO:0004083; GO:0004082; GO:0005829; GO:0006094; GO:0006096; GO:0045335; GO:0004619 bisphosphoglycerate 2-phosphatase activity; bisphosphoglycerate mutase activity; cytosol; gluconeogenesis; glycolysis; phagocytic vesicle; phosphoglycerate mutase activity IPR013078; IPR001345; IPR005952; Probable phosphoglycerate mutase (EC 3.1.3.13) (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM) (dPGM) gpmA pgam DDB_G0285311 Dictyostelium discoideum (Slime mold) TR37436_c0_g1_i4 A6L9K8 GPMA_PARD8 4.00E-94 GO:0046538; GO:0006096 "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity; glycolysis" IPR013078; IPR001345; IPR005952; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (BPG-dependent PGAM) (PGAM) (Phosphoglyceromutase) (dPGM) (EC 5.4.2.11)" gpmA BDI_0596 Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) TR37436_c0_g1_i5 Q21YW0 GPMA_RHOFD 3.00E-109 GO:0046538; GO:0006096 "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity; glycolysis" IPR013078; IPR001345; IPR005952; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (BPG-dependent PGAM) (PGAM) (Phosphoglyceromutase) (dPGM) (EC 5.4.2.11)" gpmA Rfer_1309 Rhodoferax ferrireducens (strain DSM 15236 / ATCC BAA-621 / T118) TR37436_c0_g1_i7 Q2FTH0 GPMA_METHJ 2.00E-115 GO:0046538; GO:0006096 "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity; glycolysis" IPR013078; IPR001345; IPR005952; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (BPG-dependent PGAM) (PGAM) (Phosphoglyceromutase) (dPGM) (EC 5.4.2.11)" gpmA Mhun_2324 Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1) TR37436_c0_g1_i8 Q54NE6 PGAM_DICDI 7.00E-118 GO:0004083; GO:0004082; GO:0005829; GO:0006094; GO:0006096; GO:0045335; GO:0004619 bisphosphoglycerate 2-phosphatase activity; bisphosphoglycerate mutase activity; cytosol; gluconeogenesis; glycolysis; phagocytic vesicle; phosphoglycerate mutase activity IPR013078; IPR001345; IPR005952; Probable phosphoglycerate mutase (EC 3.1.3.13) (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM) (dPGM) gpmA pgam DDB_G0285311 Dictyostelium discoideum (Slime mold) TR37437_c0_g1_i1 Q9GLK0 TGM1_CANFA 4.00E-140 GO:0031424; GO:0016020; GO:0046872; GO:0018149; GO:0003810 keratinization; membrane; metal ion binding; peptide cross-linking; protein-glutamine gamma-glutamyltransferase activity IPR023608; IPR013783; IPR014756; IPR002931; IPR008958; IPR013808; IPR001102; Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) TGM1 Canis familiaris (Dog) (Canis lupus familiaris) TR37439_c2_g1_i1 Q5RFZ7 F167A_DANRE 2.00E-19 IPR024280; Protein FAM167A fam167a si:ch211-261f7.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR37439_c2_g1_i2 Q6P1G6 F167A_MOUSE 5.00E-17 IPR024280; Protein FAM167A Fam167a Mus musculus (Mouse) TR37441_c1_g1_i2 Q9JLJ0 LITAF_MOUSE 2.00E-15 GO:0005794; GO:0050699; GO:0006915; GO:0071222; GO:0005765; GO:0042347; GO:0005886; GO:0043123; GO:0001817; GO:0006355; GO:0004871; GO:0006351 P46935 "Golgi apparatus; WW domain binding; apoptotic process; cellular response to lipopolysaccharide; lysosomal membrane; negative regulation of NF-kappaB import into nucleus; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of cytokine production; regulation of transcription, DNA-dependent; signal transducer activity; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Estrogen-enhanced transcript protein) (mEET) (LITAF-like protein) (NEDD4 WW domain-binding protein 3) Litaf N4wbp3 Tbx1 Mus musculus (Mouse) TR37441_c1_g1_i4 Q54HX8 LITAH_DICDI 3.00E-16 IPR006629; Cell death-inducing p53-target protein 1 homolog (Protein LITAF homolog) litaf DDB_G0289149 Dictyostelium discoideum (Slime mold) TR37441_c1_g1_i8 Q9JLJ0 LITAF_MOUSE 8.00E-18 GO:0005794; GO:0050699; GO:0006915; GO:0071222; GO:0005765; GO:0042347; GO:0005886; GO:0043123; GO:0001817; GO:0006355; GO:0004871; GO:0006351 P46935 "Golgi apparatus; WW domain binding; apoptotic process; cellular response to lipopolysaccharide; lysosomal membrane; negative regulation of NF-kappaB import into nucleus; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of cytokine production; regulation of transcription, DNA-dependent; signal transducer activity; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Estrogen-enhanced transcript protein) (mEET) (LITAF-like protein) (NEDD4 WW domain-binding protein 3) Litaf N4wbp3 Tbx1 Mus musculus (Mouse) TR37442_c0_g1_i1 A4FV48 FADS2_BOVIN 1.00E-148 GO:0005789; GO:0020037; GO:0016021; GO:0005506; GO:0004768; GO:0006636 endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding; stearoyl-CoA 9-desaturase activity; unsaturated fatty acid biosynthetic process IPR001199; IPR012171; IPR005804; Lipid metabolism; polyunsaturated fatty acid biosynthesis. Fatty acid desaturase 2 (EC 1.14.19.-) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase) FADS2 Bos taurus (Bovine) TR37442_c0_g1_i3 Q8NKG9 SLD1_LACK1 2.00E-07 GO:0006633; GO:0020037; GO:0016021; GO:0005506; GO:0016717; GO:0006665 "fatty acid biosynthetic process; heme binding; integral to membrane; iron ion binding; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; sphingolipid metabolic process" IPR001199; IPR012171; IPR005804; Delta(8)-fatty-acid desaturase (EC 1.14.19.4) (Delta(8)-sphingolipid desaturase) SLD Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / CCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651) (Yeast) (Saccharomyces kluyveri) TR37444_c0_g1_i1 Q6PA90 LRG2A_XENLA 9.00E-11 GO:0000139; GO:0016021; GO:0016757 "Golgi membrane; integral to membrane; transferase activity, transferring glycosyl groups" IPR002495; Glycosyltransferase-like protein LARGE2-A (EC 2.4.-.-) (Glycosyltransferase-like 1B-A) gyltl1b-a Xenopus laevis (African clawed frog) TR37444_c0_g1_i2 Q54PG8 GNT14_DICDI 4.00E-14 GO:0016021 integral to membrane Glycosyltransferase-like protein gnt14 gnt14 DDB_G0284567 Dictyostelium discoideum (Slime mold) TR37444_c0_g3_i1 Q21389 LGE1_CAEEL 5.00E-07 GO:0000139; GO:0016021; GO:0016757 "Golgi membrane; integral to membrane; transferase activity, transferring glycosyl groups" IPR002495; Glycosyltransferase-like protein LARGE (EC 2.4.-.-) lge-1 K09C8.4 Caenorhabditis elegans TR37444_c0_g3_i2 Q5R4S2 B3GN1_PONAB 3.00E-33 GO:0000139; GO:0008532; GO:0016021; GO:0006486 "Golgi membrane; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity; integral to membrane; protein glycosylation" IPR026603; Protein modification; protein glycosylation. "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.149) (I-beta-1,3-N-acetylglucosaminyltransferase) (iGnT) (Poly-N-acetyllactosamine extension enzyme) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1)" B3GNT1 B3GNT6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37445_c5_g1_i1 Q3T106 SRSF7_BOVIN 2.00E-22 GO:0003723; GO:0008380; GO:0006397; GO:0048025; GO:0000166; GO:0005634; GO:0008270 "RNA binding; RNA splicing; mRNA processing; negative regulation of mRNA splicing, via spliceosome; nucleotide binding; nucleus; zinc ion binding" IPR012677; IPR000504; IPR001878; "Serine/arginine-rich splicing factor 7 (Splicing factor, arginine/serine-rich 7)" SRSF7 SFRS7 Bos taurus (Bovine) TR37445_c5_g1_i2 O81126 RZP22_ARATH 2.00E-09 GO:0005737; GO:0000398; GO:0016607; GO:0003676; GO:0005730; GO:0000166; GO:0008270 Q42404 "cytoplasm; mRNA splicing, via spliceosome; nuclear speck; nucleic acid binding; nucleolus; nucleotide binding; zinc ion binding" IPR012677; IPR000504; IPR001878; Serine/arginine-rich splicing factor RSZ22 (RS-containing zinc finger protein 22) (At-RSZ22) (At-RSZp22) RSZ22 RSZP22 SRZ22 At4g31580 F28M20.230 Arabidopsis thaliana (Mouse-ear cress) TR37445_c5_g1_i3 Q8C7Q4 RBM4_MOUSE 5.00E-06 GO:0002192; GO:0008380; GO:0030154; GO:0097167; GO:0010494; GO:0043153; GO:0003730; GO:0006397; GO:0035198; GO:0032055; GO:0035278; GO:0045947; GO:0016607; GO:0005730; GO:0000166; GO:0048471; GO:0051149; GO:0097158; GO:0000381; GO:0046822; GO:0046685; GO:0051403; GO:0008270 "IRES-dependent translational initiation; RNA splicing; cell differentiation; circadian regulation of translation; cytoplasmic stress granule; entrainment of circadian clock by photoperiod; mRNA 3'-UTR binding; mRNA processing; miRNA binding; negative regulation of translation in response to stress; negative regulation of translation involved in gene silencing by miRNA; negative regulation of translational initiation; nuclear speck; nucleolus; nucleotide binding; perinuclear region of cytoplasm; positive regulation of muscle cell differentiation; pre-mRNA intronic pyrimidine-rich binding; regulation of alternative mRNA splicing, via spliceosome; regulation of nucleocytoplasmic transport; response to arsenic-containing substance; stress-activated MAPK cascade; zinc ion binding" IPR012677; IPR000504; IPR001878; RNA-binding protein 4 (Lark homolog) (mLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a) Rbm4 Rbm4a Mus musculus (Mouse) TR37445_c5_g1_i6 Q3T106 SRSF7_BOVIN 2.00E-22 GO:0003723; GO:0008380; GO:0006397; GO:0048025; GO:0000166; GO:0005634; GO:0008270 "RNA binding; RNA splicing; mRNA processing; negative regulation of mRNA splicing, via spliceosome; nucleotide binding; nucleus; zinc ion binding" IPR012677; IPR000504; IPR001878; "Serine/arginine-rich splicing factor 7 (Splicing factor, arginine/serine-rich 7)" SRSF7 SFRS7 Bos taurus (Bovine) TR37445_c5_g1_i7 Q3T106 SRSF7_BOVIN 2.00E-22 GO:0003723; GO:0008380; GO:0006397; GO:0048025; GO:0000166; GO:0005634; GO:0008270 "RNA binding; RNA splicing; mRNA processing; negative regulation of mRNA splicing, via spliceosome; nucleotide binding; nucleus; zinc ion binding" IPR012677; IPR000504; IPR001878; "Serine/arginine-rich splicing factor 7 (Splicing factor, arginine/serine-rich 7)" SRSF7 SFRS7 Bos taurus (Bovine) TR37446_c0_g3_i1 Q9NYQ8 FAT2_HUMAN 2.00E-16 GO:0005509; GO:0005913; GO:0010631; GO:0007156; GO:0016021; GO:0005634; GO:0005886 calcium ion binding; cell-cell adherens junction; epithelial cell migration; homophilic cell adhesion; integral to membrane; nucleus; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR013032; IPR001791; Protocadherin Fat 2 (hFat2) (Cadherin family member 8) (Multiple epidermal growth factor-like domains protein 1) (Multiple EGF-like domains protein 1) FAT2 CDHF8 KIAA0811 MEGF1 Homo sapiens (Human) TR37446_c0_g3_i2 Q08174 PCDH1_HUMAN 1.00E-07 GO:0005509; GO:0005911; GO:0007267; GO:0007156; GO:0005887; GO:0007399 calcium ion binding; cell-cell junction; cell-cell signaling; homophilic cell adhesion; integral to plasma membrane; nervous system development IPR002126; IPR015919; IPR020894; IPR013164; IPR013585; Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) PCDH1 Homo sapiens (Human) TR37447_c7_g1_i1 P29594 CASP2_MOUSE 5.00E-07 GO:0006977; GO:0007568; GO:0007420; GO:0071260; GO:0097153; GO:0005737; GO:0097192; GO:0035234; GO:0001554; GO:0016020; GO:0005739; GO:0043066; GO:0003407; GO:0005634; GO:0043065; GO:2001235; GO:0043525; GO:0016485; GO:0006508 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; aging; brain development; cellular response to mechanical stimulus; cysteine-type endopeptidase activity involved in apoptotic process; cytoplasm; extrinsic apoptotic signaling pathway in absence of ligand; germ cell programmed cell death; luteolysis; membrane; mitochondrion; negative regulation of apoptotic process; neural retina development; nucleus; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of neuron apoptotic process; protein processing; proteolysis" IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] Casp2 Ich1 Nedd-2 Nedd2 Mus musculus (Mouse) TR37447_c7_g2_i1 Q8MJU1 CASP3_FELCA 1.00E-08 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Felis catus (Cat) (Felis silvestris catus) TR37447_c7_g2_i2 Q98943 CASP2_CHICK 1.00E-06 GO:0006915; GO:0004197; GO:0005622; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; intracellular; proteolysis; regulation of apoptotic process IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) TR37448_c6_g2_i2 Q58CN9 NAPEP_BOVIN 2.00E-89 GO:0070290; GO:0016020; GO:0009395; GO:0008270 NAPE-specific phospholipase D activity; membrane; phospholipid catabolic process; zinc ion binding IPR001279; IPR024884; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (N-acyl phosphatidylethanolamine phospholipase D) (NAPE-PLD) (NAPE-hydrolyzing phospholipase D) (EC 3.1.4.54) NAPEPLD Bos taurus (Bovine) TR37448_c6_g2_i3 Q6IQ20 NAPEP_HUMAN 7.00E-87 GO:0070290; GO:0009395; GO:0042622; GO:0008270 NAPE-specific phospholipase D activity; phospholipid catabolic process; photoreceptor outer segment membrane; zinc ion binding IPR001279; IPR024884; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (N-acyl phosphatidylethanolamine phospholipase D) (NAPE-PLD) (NAPE-hydrolyzing phospholipase D) (EC 3.1.4.54) NAPEPLD C7orf18 Homo sapiens (Human) TR37448_c6_g2_i5 Q02883 FMP30_YEAST 5.00E-42 GO:0070291; GO:0070292; GO:0070290; GO:0031305; GO:0009395; GO:0008270 N-acylethanolamine metabolic process; N-acylphosphatidylethanolamine metabolic process; NAPE-specific phospholipase D activity; integral to mitochondrial inner membrane; phospholipid catabolic process; zinc ion binding IPR001279; IPR024884; "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, mitochondrial (NAPE-PLD) (NAPE-hydrolyzing phospholipase D) (EC 3.1.4.54) (Found in mitochondrial proteome protein 30)" FMP30 YPL103C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR37450_c0_g1_i1 Q26619 KAPR_STRPU 4.00E-142 GO:0030552; GO:0005952; GO:0008603 cAMP binding; cAMP-dependent protein kinase complex; cAMP-dependent protein kinase regulator activity IPR002373; IPR012198; IPR003117; IPR018490; IPR018488; IPR000595; IPR014710; cAMP-dependent protein kinase type II regulatory subunit Strongylocentrotus purpuratus (Purple sea urchin) TR37450_c0_g1_i10 Q26619 KAPR_STRPU 8.00E-148 GO:0030552; GO:0005952; GO:0008603 cAMP binding; cAMP-dependent protein kinase complex; cAMP-dependent protein kinase regulator activity IPR002373; IPR012198; IPR003117; IPR018490; IPR018488; IPR000595; IPR014710; cAMP-dependent protein kinase type II regulatory subunit Strongylocentrotus purpuratus (Purple sea urchin) TR37450_c0_g1_i2 P31322 KAP3_BOVIN 4.00E-132 GO:0030552; GO:0005952; GO:0008603; GO:0005737; GO:0005886 cAMP binding; cAMP-dependent protein kinase complex; cAMP-dependent protein kinase regulator activity; cytoplasm; plasma membrane IPR002373; IPR012198; IPR003117; IPR018490; IPR018488; IPR000595; IPR014710; cAMP-dependent protein kinase type II-beta regulatory subunit PRKAR2B Bos taurus (Bovine) TR37450_c0_g1_i4 Q26619 KAPR_STRPU 3.00E-146 GO:0030552; GO:0005952; GO:0008603 cAMP binding; cAMP-dependent protein kinase complex; cAMP-dependent protein kinase regulator activity IPR002373; IPR012198; IPR003117; IPR018490; IPR018488; IPR000595; IPR014710; cAMP-dependent protein kinase type II regulatory subunit Strongylocentrotus purpuratus (Purple sea urchin) TR37450_c0_g1_i6 Q26619 KAPR_STRPU 3.00E-146 GO:0030552; GO:0005952; GO:0008603 cAMP binding; cAMP-dependent protein kinase complex; cAMP-dependent protein kinase regulator activity IPR002373; IPR012198; IPR003117; IPR018490; IPR018488; IPR000595; IPR014710; cAMP-dependent protein kinase type II regulatory subunit Strongylocentrotus purpuratus (Purple sea urchin) TR37451_c4_g2_i3 Q17R13 ACK1_BOVIN 2.00E-12 GO:0005524; GO:0005912; GO:0030136; GO:0005905; GO:0030659; GO:0006897; GO:0005768; GO:0046872; GO:0004715; GO:0005634; GO:0018108; GO:0005886; GO:0004674 Q9Y5X1 ATP binding; adherens junction; clathrin-coated vesicle; coated pit; cytoplasmic vesicle membrane; endocytosis; endosome; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleus; peptidyl-tyrosine phosphorylation; plasma membrane; protein serine/threonine kinase activity IPR015116; IPR021619; IPR011009; IPR000719; IPR017441; IPR001245; IPR001452; IPR008266; IPR020635; IPR009060; IPR015940; IPR000449; Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Activated CDC42 kinase 2) (Tyrosine kinase non-receptor protein 2) TNK2 ACK1 ACK2 Bos taurus (Bovine) TR37451_c4_g2_i4 Q13470 TNK1_HUMAN 1.00E-08 GO:0005524; GO:0005737; GO:0005829; GO:0016020; GO:0046580; GO:0030308; GO:0004715; GO:0046777; GO:0004871 ATP binding; cytoplasm; cytosol; membrane; negative regulation of Ras protein signal transduction; negative regulation of cell growth; non-membrane spanning protein tyrosine kinase activity; protein autophosphorylation; signal transducer activity IPR011009; IPR000719; IPR017441; IPR001245; IPR001452; IPR008266; IPR020635; Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) TNK1 Homo sapiens (Human) TR37455_c2_g1_i1 P86789 GIGA6_CRAGI 5.00E-36 GO:0016021 integral to membrane IPR001466; IPR012338; Gigasin-6 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) TR37456_c2_g1_i1 Q5F4A9 AR6P4_CHICK 6.00E-30 IPR019532; ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL-6-interacting protein 4) (Aip-4) ARL6IP4 RCJMB04_1f2 Gallus gallus (Chicken) TR37458_c0_g2_i1 Q640R7 RAP1B_XENTR 5.00E-96 GO:0005525; GO:0003924; GO:0030054; GO:0005829; GO:0005886; GO:0007264 GTP binding; GTPase activity; cell junction; cytosol; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; Ras-related protein Rap-1b rap1b TTpA008e07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37459_c6_g1_i3 Q5S007 LRRK2_HUMAN 1.00E-07 GO:0005524; GO:0005525; GO:0034211; GO:0005096; GO:0003924; GO:0004708; GO:0000186; GO:0006914; GO:0032839; GO:0008340; GO:0035640; GO:0032473; GO:0048312; GO:0045121; GO:0034260; GO:2000173; GO:0061002; GO:0007406; GO:0014043; GO:0007528; GO:0070997; GO:0043025; GO:0018105; GO:0018107; GO:0005886; GO:0010508; GO:0060161; GO:0043068; GO:0032436; GO:0031398; GO:0046777; GO:0035564; GO:0040012; GO:0042391; GO:0006979; GO:0007264; GO:0008021; GO:0022028; GO:0005802; GO:0015631 Itself; Q9UKV8; P31749; Q8N6T3-2; Q62848; Q14155; Q16543; P60953; P30275; P53355; O00429; O00429-3; O14640-2; O14641; Q92997; Q13158; P11142; O75581; Q38SD2; P46734; P52564; O14733; P10636-8; P02687; P26038; Q13469; O60260; P30048; P61020; P61021; Q63481; P63000; Q99962; P37840; Q58A65; P31946; P62258; P61981; Q04917; P27348; P63104 ATP binding; GTP binding; GTP-dependent protein kinase activity; GTPase activator activity; GTPase activity; MAP kinase kinase activity; activation of MAPKK activity; autophagy; dendrite cytoplasm; determination of adult lifespan; exploration behavior; external side of mitochondrial outer membrane; intracellular distribution of mitochondria; membrane raft; negative regulation of GTPase activity; negative regulation of branching morphogenesis of a nerve; negative regulation of dendritic spine morphogenesis; negative regulation of neuroblast proliferation; negative regulation of neuron maturation; neuromuscular junction development; neuron death; neuronal cell body; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; plasma membrane; positive regulation of autophagy; positive regulation of dopamine receptor signaling pathway; positive regulation of programmed cell death; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; protein autophosphorylation; regulation of kidney size; regulation of locomotion; regulation of membrane potential; response to oxidative stress; small GTPase mediated signal transduction; synaptic vesicle; tangential migration from the subventricular zone to the olfactory bulb; trans-Golgi network; tubulin binding IPR020683; IPR011989; IPR016024; IPR011009; IPR001611; IPR025875; IPR003591; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR008271; IPR005225; IPR001806; IPR015943; IPR001680; IPR017986; Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin) LRRK2 PARK8 Homo sapiens (Human) TR37459_c6_g1_i4 Q6XHB2 ROCO4_DICDI 1.00E-07 GO:0005524; GO:0005525; GO:0005829; GO:0004672; GO:0004674; GO:0031153; GO:0007264; GO:0031150 ATP binding; GTP binding; cytosol; protein kinase activity; protein serine/threonine kinase activity; slug development involved in sorocarp development; small GTPase mediated signal transduction; sorocarp stalk development IPR011009; IPR001611; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR001245; IPR015943; IPR001680; IPR017986; Probable serine/threonine-protein kinase roco4 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 4) roco4 DDB_G0288251 Dictyostelium discoideum (Slime mold) TR37459_c6_g5_i1 Q8SSS9 QKGA_DICDI 6.00E-06 GO:0005524; GO:0005525; GO:0005737; GO:0031158; GO:0008285; GO:0006997; GO:0004674; GO:0007264 ATP binding; GTP binding; cytoplasm; negative regulation of aggregate size involved in sorocarp development; negative regulation of cell proliferation; nucleus organization; protein serine/threonine kinase activity; small GTPase mediated signal transduction IPR011009; IPR001611; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR001245; Probable serine/threonine-protein kinase qkgA (EC 2.7.11.1) (Quick growth protein qkgA) (Ras of complex proteins and C-terminal of roc 2) qkgA-1 roco2-1 DDB_G0273259; qkgA-2 roco2-2 DDB_G0273635 Dictyostelium discoideum (Slime mold) TR37460_c0_g1_i1 Q91VY9 ZN622_MOUSE 9.00E-78 GO:0005794; GO:0008631; GO:0003676; GO:0005730; GO:0046330; GO:0043065; GO:0033674; GO:0008270 Golgi apparatus; intrinsic apoptotic signaling pathway in response to oxidative stress; nucleic acid binding; nucleolus; positive regulation of JNK cascade; positive regulation of apoptotic process; positive regulation of kinase activity; zinc ion binding IPR007087; IPR015880; IPR022755; IPR003604; Zinc finger protein 622 Znf622 D15Ertd806e Zfp622 Mus musculus (Mouse) TR37461_c1_g1_i1 Q5REH2 ZDHC6_PONAB 3.00E-103 GO:0005789; GO:0016021; GO:0016746; GO:0008270 "endoplasmic reticulum membrane; integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR011511; IPR001452; IPR001594; Palmitoyltransferase ZDHHC6 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 6) (DHHC-6) ZDHHC6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37461_c1_g1_i11 Q93VV0 ZDHC6_ARATH 2.00E-27 GO:0000139; GO:0016021; GO:0016746; GO:0008270 "Golgi membrane; integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Probable protein S-acyltransferase 16 (EC 2.3.1.225) (Probable palmitoyltransferase At3g09320) (Zinc finger DHHC domain-containing protein At3g09320) PAT16 At3g09320 F3L24.19 Arabidopsis thaliana (Mouse-ear cress) TR37461_c1_g1_i13 Q4PE27 PFA4_USTMA 1.00E-28 GO:0005789; GO:0016021; GO:0016746; GO:0008270 "endoplasmic reticulum membrane; integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Palmitoyltransferase PFA4 (EC 2.3.1.225) (Protein fatty acyltransferase 4) PFA4 UM01636 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR37461_c1_g1_i14 Q5REH2 ZDHC6_PONAB 2.00E-136 GO:0005789; GO:0016021; GO:0016746; GO:0008270 "endoplasmic reticulum membrane; integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR011511; IPR001452; IPR001594; Palmitoyltransferase ZDHHC6 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 6) (DHHC-6) ZDHHC6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37461_c1_g1_i2 Q5REH2 ZDHC6_PONAB 9.00E-138 GO:0005789; GO:0016021; GO:0016746; GO:0008270 "endoplasmic reticulum membrane; integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR011511; IPR001452; IPR001594; Palmitoyltransferase ZDHHC6 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 6) (DHHC-6) ZDHHC6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37461_c1_g1_i6 O80685 ZDHC4_ARATH 2.00E-10 GO:0030659; GO:0016021; GO:0016746; GO:0008270 "cytoplasmic vesicle membrane; integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Probable protein S-acyltransferase 2 (EC 2.3.1.225) (Probable palmitoyltransferase At2g40990) (Zinc finger DHHC domain-containing protein At2g40990) PAT02 At2g40990 T3K9.24 Arabidopsis thaliana (Mouse-ear cress) TR37461_c1_g1_i7 Q93VV0 ZDHC6_ARATH 9.00E-28 GO:0000139; GO:0016021; GO:0016746; GO:0008270 "Golgi membrane; integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Probable protein S-acyltransferase 16 (EC 2.3.1.225) (Probable palmitoyltransferase At3g09320) (Zinc finger DHHC domain-containing protein At3g09320) PAT16 At3g09320 F3L24.19 Arabidopsis thaliana (Mouse-ear cress) TR37461_c1_g1_i8 Q4PE27 PFA4_USTMA 5.00E-29 GO:0005789; GO:0016021; GO:0016746; GO:0008270 "endoplasmic reticulum membrane; integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Palmitoyltransferase PFA4 (EC 2.3.1.225) (Protein fatty acyltransferase 4) PFA4 UM01636 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR37462_c0_g1_i1 Q969X6 CIR1A_HUMAN 2.00E-132 GO:0030490; GO:0006355; GO:0034455; GO:0006351 P15822 "maturation of SSU-rRNA; regulation of transcription, DNA-dependent; t-UTP complex; transcription, DNA-dependent" IPR015943; IPR001680; IPR017986; Cirhin CIRH1A KIAA1988 UTP4 Homo sapiens (Human) TR37462_c0_g1_i2 Q969X6 CIR1A_HUMAN 1.00E-38 GO:0030490; GO:0006355; GO:0034455; GO:0006351 P15822 "maturation of SSU-rRNA; regulation of transcription, DNA-dependent; t-UTP complex; transcription, DNA-dependent" IPR015943; IPR001680; IPR017986; Cirhin CIRH1A KIAA1988 UTP4 Homo sapiens (Human) TR37463_c3_g1_i3 P48579 PP2A_HELAN 1.00E-149 GO:0046872; GO:0004721 metal ion binding; phosphoprotein phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP2A catalytic subunit (EC 3.1.3.16) Helianthus annuus (Common sunflower) TR37463_c3_g1_i4 Q5R6K8 PP4C_PONAB 0 GO:0005737; GO:0046872; GO:0005815; GO:0005634; GO:0004722; GO:0010569 cytoplasm; metal ion binding; microtubule organizing center; nucleus; protein serine/threonine phosphatase activity; regulation of double-strand break repair via homologous recombination IPR004843; IPR006186; Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) PPP4C Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37463_c3_g1_i5 A0CNL9 PP2A2_PARTE 5.00E-134 GO:0046872; GO:0004721 metal ion binding; phosphoprotein phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP2A catalytic subunit 2 (PPN 2) (EC 3.1.3.16) Ppn2 GSPATT00008828001 Paramecium tetraurelia TR37465_c0_g2_i1 P50636 RN19A_MOUSE 0 GO:0005737; GO:0016021; GO:0016874; GO:0005815; GO:0016567; GO:0008270 Q9Z0P7 cytoplasm; integral to membrane; ligase activity; microtubule organizing center; protein ubiquitination; zinc ion binding IPR002867; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF19A (EC 6.3.2.-) (Double ring-finger protein) (Dorfin) (Gametogenesis-expressed protein GEG-154) (RING finger protein 19A) (UBCM4-interacting protein 117) (UIP117) (XY body protein) (XYbp) Rnf19a Geg-154 Rnf19 Xybp Mus musculus (Mouse) TR37466_c1_g1_i1 Q8NFD2 ANKK1_HUMAN 1.00E-28 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR001245; IPR008271; Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) TR37466_c1_g1_i2 Q59H18 TNI3K_HUMAN 0 GO:0005524; GO:0005737; GO:0046872; GO:0005634; GO:0004672; GO:0004674 P19429 ATP binding; cytoplasm; metal ion binding; nucleus; protein kinase activity; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR017441; IPR001245; Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase) TNNI3K CARK Homo sapiens (Human) TR37466_c1_g1_i3 P16157 ANK1_HUMAN 2.00E-37 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR37466_c1_g1_i4 Q8BZ25 ANKK1_MOUSE 9.00E-27 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR001245; IPR008271; Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) Ankk1 Mus musculus (Mouse) TR37466_c1_g1_i5 Q59H18 TNI3K_HUMAN 0 GO:0005524; GO:0005737; GO:0046872; GO:0005634; GO:0004672; GO:0004674 P19429 ATP binding; cytoplasm; metal ion binding; nucleus; protein kinase activity; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR017441; IPR001245; Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase) TNNI3K CARK Homo sapiens (Human) TR37466_c1_g1_i6 Q8C8R3 ANK2_MOUSE 1.00E-33 GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005887; GO:0014704; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086015; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307 "M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; integral to plasma membrane; intercalated disc; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of SA node cell action potential; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Brain ankyrin) Ank2 Mus musculus (Mouse) TR37466_c1_g1_i7 P18161 SPLB_DICDI 2.00E-42 GO:0005524; GO:0004715; GO:2000366; GO:0004713; GO:0007260 ATP binding; non-membrane spanning protein tyrosine kinase activity; positive regulation of STAT protein import into nucleus; protein tyrosine kinase activity; tyrosine phosphorylation of STAT protein IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; Dual specificity protein kinase splB (EC 2.7.10.2) (Non-receptor tyrosine kinase spore lysis B) (Tyrosine-protein kinase 2) splB DpyK2 pyk2 pykB DDB_G0285321 Dictyostelium discoideum (Slime mold) TR37467_c0_g1_i1 Q9H0A0 NAT10_HUMAN 0 GO:0005524; GO:0008080; GO:0005730; GO:0005634 Q9NX58 ATP binding; N-acetyltransferase activity; nucleolus; nucleus IPR016181; IPR013562; IPR000182; IPR007807; IPR027992; N-acetyltransferase 10 (EC 2.3.1.-) NAT10 ALP KIAA1709 Homo sapiens (Human) TR37468_c0_g1_i2 Q04799 FMO5_RABIT 2.00E-23 GO:0004499; GO:0050661; GO:0005789; GO:0050660; GO:0016021 "N,N-dimethylaniline monooxygenase activity; NADP binding; endoplasmic reticulum membrane; flavin adenine dinucleotide binding; integral to membrane" IPR012143; IPR000960; IPR020946; IPR002257; IPR016040; Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (FMO 1C1) (FMO form 3) (Hepatic flavin-containing monooxygenase 5) (FMO 5) FMO5 Oryctolagus cuniculus (Rabbit) TR37468_c0_g1_i3 Q94K43 GSOX2_ARATH 6.00E-37 GO:0080102; GO:0080103; GO:0080104; GO:0080106; GO:0080107; GO:0004499; GO:0050661; GO:0050660; GO:0019761 "3-methylthiopropyl glucosinolate S-oxygenase activity; 4-methylthiopropyl glucosinolate S-oxygenase activity; 5-methylthiopropyl glucosinolate S-oxygenase activity; 7-methylthiopropyl glucosinolate S-oxygenase activity; 8-methylthiopropyl glucosinolate S-oxygenase activity; N,N-dimethylaniline monooxygenase activity; NADP binding; flavin adenine dinucleotide binding; glucosinolate biosynthetic process" IPR000960; IPR020946; Flavin-containing monooxygenase FMO GS-OX2 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase 2) FMOGS-OX2 At1g62540 T3P18.10 Arabidopsis thaliana (Mouse-ear cress) TR37470_c0_g1_i3 Q9Y2M2 CC032_HUMAN 5.00E-44 GO:0005737 cytoplasm Protein SSUH2 homolog (Protein ssu-2 homolog) SSUH2 C3orf32 FLS485 Homo sapiens (Human) TR37470_c0_g1_i4 Q9Y2M2 CC032_HUMAN 5.00E-44 GO:0005737 cytoplasm Protein SSUH2 homolog (Protein ssu-2 homolog) SSUH2 C3orf32 FLS485 Homo sapiens (Human) TR37470_c0_g1_i6 Q9Y2M2 CC032_HUMAN 5.00E-44 GO:0005737 cytoplasm Protein SSUH2 homolog (Protein ssu-2 homolog) SSUH2 C3orf32 FLS485 Homo sapiens (Human) TR37471_c5_g1_i15 Q3BAI2 YCX91_PHAAO 7.00E-17 GO:0009507 chloroplast Uncharacterized protein ORF91 Phalaenopsis aphrodite subsp. formosana (Moth orchid) TR37471_c5_g1_i4 Q3BAI2 YCX91_PHAAO 3.00E-16 GO:0009507 chloroplast Uncharacterized protein ORF91 Phalaenopsis aphrodite subsp. formosana (Moth orchid) TR37472_c2_g1_i1 Q5ZK33 LETM1_CHICK 1.00E-59 GO:0005509; GO:0016021; GO:0005743 calcium ion binding; integral to membrane; mitochondrial inner membrane IPR011992; IPR002048; IPR011685; "LETM1 and EF-hand domain-containing protein 1, mitochondrial (Leucine zipper-EF-hand-containing transmembrane protein 1)" LETM1 RCJMB04_13i11 Gallus gallus (Chicken) TR37473_c4_g1_i1 Q8TCB7 METL6_HUMAN 6.00E-34 GO:0008168 methyltransferase activity IPR013217; IPR026113; Methyltransferase-like protein 6 (EC 2.1.1.-) METTL6 Homo sapiens (Human) TR37473_c4_g1_i2 Q8TCB7 METL6_HUMAN 8.00E-107 GO:0008168 methyltransferase activity IPR013217; IPR026113; Methyltransferase-like protein 6 (EC 2.1.1.-) METTL6 Homo sapiens (Human) TR37473_c4_g1_i5 Q8BVH9 METL6_MOUSE 9.00E-105 GO:0008168 methyltransferase activity IPR013217; IPR026113; Methyltransferase-like protein 6 (EC 2.1.1.-) Mettl6 Mus musculus (Mouse) TR37473_c4_g3_i1 Q04833 LRP_CAEEL 5.00E-08 GO:0016324; GO:0005509; GO:0005905; GO:0042395; GO:0030139; GO:0006897; GO:0016021; GO:0002119; GO:0040017; GO:0040018; GO:0030334; GO:0015248 "apical plasma membrane; calcium ion binding; coated pit; ecdysis, collagen and cuticulin-based cuticle; endocytic vesicle; endocytosis; integral to membrane; nematode larval development; positive regulation of locomotion; positive regulation of multicellular organism growth; regulation of cell migration; sterol transporter activity" IPR011042; IPR000742; IPR001881; IPR013032; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein (LRP) lrp-1 F29D11.1 Caenorhabditis elegans TR37475_c4_g1_i1 B4HQ29 FBSP1_DROSE 2.00E-137 GO:0030054; GO:0045886; GO:0007399; GO:0031594; GO:0007274; GO:0016567 cell junction; negative regulation of synaptic growth at neuromuscular junction; nervous system development; neuromuscular junction; neuromuscular synaptic transmission; protein ubiquitination IPR001870; IPR008985; IPR001810; IPR018355; IPR003877; Protein modification; protein ubiquitination. F-box/SPRY domain-containing protein 1 Fsn GM20297 Drosophila sechellia (Fruit fly) TR37478_c1_g1_i1 P16005 ACHB_CHICK 3.00E-08 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR006202; IPR006201; IPR002394; Acetylcholine receptor subunit beta (Fragment) CHRNB1 Gallus gallus (Chicken) TR37478_c1_g1_i2 Q9PTS8 ACHA9_CHICK 3.00E-96 GO:0004889; GO:0005262; GO:0030054; GO:0007204; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; calcium channel activity; cell junction; elevation of cytosolic calcium ion concentration; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9) CHRNA9 Gallus gallus (Chicken) TR37479_c1_g1_i1 Q58DS3 S2535_BOVIN 2.00E-15 GO:0016021; GO:0005743; GO:0006810 integral to membrane; mitochondrial inner membrane; transport IPR018108; IPR023395; Solute carrier family 25 member 35 SLC25A35 Bos taurus (Bovine) TR37479_c1_g1_i2 B0G143 UCPB_DICDI 2.00E-60 GO:0016021; GO:0005743; GO:0006839 integral to membrane; mitochondrial inner membrane; mitochondrial transport IPR002030; IPR018108; IPR023395; Mitochondrial substrate carrier family protein ucpB (Solute carrier family 25 member 30 homolog) (Uncoupler protein B) ucpB slc25a30 DDB_G0283333 Dictyostelium discoideum (Slime mold) TR37479_c2_g2_i1 P53395 ODB2_MOUSE 6.00E-102 GO:0048037; GO:0043754; GO:0046949; GO:0005759; GO:0005739 cofactor binding; dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity; fatty-acyl-CoA biosynthetic process; mitochondrial matrix; mitochondrion IPR003016; IPR001078; IPR000089; IPR023213; IPR004167; IPR015761; IPR011053; "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase)" Dbt Mus musculus (Mouse) TR37479_c2_g2_i2 P86219 ODO2_MESAU 1.00E-06 GO:0033512; GO:0004149; GO:0005739; GO:0006099 L-lysine catabolic process to acetyl-CoA via saccharopine; dihydrolipoyllysine-residue succinyltransferase activity; mitochondrion; tricarboxylic acid cycle IPR001078; IPR023213; Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6. "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K) (Fragments)" DLST Mesocricetus auratus (Golden hamster) TR37479_c2_g2_i3 P53395 ODB2_MOUSE 7.00E-107 GO:0048037; GO:0043754; GO:0046949; GO:0005759; GO:0005739 cofactor binding; dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity; fatty-acyl-CoA biosynthetic process; mitochondrial matrix; mitochondrion IPR003016; IPR001078; IPR000089; IPR023213; IPR004167; IPR015761; IPR011053; "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase)" Dbt Mus musculus (Mouse) TR37480_c1_g2_i1 Q8BHJ9 SLU7_MOUSE 0 GO:0000380; GO:0071013; GO:0033554; GO:0005737; GO:0006886; GO:0000389; GO:0016607; GO:0030628; GO:0000386; GO:0030532; GO:0005681; GO:0008270 "alternative mRNA splicing, via spliceosome; catalytic step 2 spliceosome; cellular response to stress; cytoplasm; intracellular protein transport; mRNA 3'-splice site recognition; nuclear speck; pre-mRNA 3'-splice site binding; second spliceosomal transesterification activity; small nuclear ribonucleoprotein complex; spliceosomal complex; zinc ion binding" IPR021715; IPR001878; Pre-mRNA-splicing factor SLU7 Slu7 D11Ertd730e Mus musculus (Mouse) TR37480_c2_g1_i11 A4FUZ5 SERC3_BOVIN 2.00E-125 GO:0000139; GO:0016021; GO:0005886 Golgi membrane; integral to membrane; plasma membrane IPR005016; Serine incorporator 3 SERINC3 Bos taurus (Bovine) TR37480_c2_g1_i2 A4FUZ5 SERC3_BOVIN 9.00E-126 GO:0000139; GO:0016021; GO:0005886 Golgi membrane; integral to membrane; plasma membrane IPR005016; Serine incorporator 3 SERINC3 Bos taurus (Bovine) TR37480_c2_g1_i4 Q96SA4 SERC2_HUMAN 5.00E-98 GO:0016021; GO:0006658; GO:0051347 integral to membrane; phosphatidylserine metabolic process; positive regulation of transferase activity IPR005016; Serine incorporator 2 (Tumor differentially expressed protein 2-like) SERINC2 TDE2L FKSG84 UNQ263/PRO300 Homo sapiens (Human) TR37480_c2_g1_i5 A4FUZ5 SERC3_BOVIN 8.00E-126 GO:0000139; GO:0016021; GO:0005886 Golgi membrane; integral to membrane; plasma membrane IPR005016; Serine incorporator 3 SERINC3 Bos taurus (Bovine) TR37480_c2_g1_i9 Q7TNK0 SERC1_RAT 1.00E-123 GO:0015194; GO:0005789; GO:0016021; GO:0006658; GO:0008654; GO:0005886; GO:0051347; GO:0006665 L-serine transmembrane transporter activity; endoplasmic reticulum membrane; integral to membrane; phosphatidylserine metabolic process; phospholipid biosynthetic process; plasma membrane; positive regulation of transferase activity; sphingolipid metabolic process IPR005016; Serine incorporator 1 (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2) Serinc1 Tde1l Tde2 Rattus norvegicus (Rat) TR37482_c0_g1_i4 Q5EB73 TM246_RAT 2.00E-32 GO:0016021 integral to membrane Transmembrane protein 246 Tmem246 Rattus norvegicus (Rat) TR37484_c2_g1_i3 P63182 CBLN1_RAT 6.00E-07 GO:0030054; GO:0005576; GO:0051965; GO:0045211; GO:0009306 cell junction; extracellular region; positive regulation of synapse assembly; postsynaptic membrane; protein secretion IPR001073; IPR008983; Cerebellin-1 (Precerebellin) [Cleaved into: Cerebellin (CER); [des-Ser1]-cerebellin (des-Ser(1)-cerebellin) ([des-Ser1]CER) (des-CER) (des-Ser1CER)] Cbln1 Rattus norvegicus (Rat) TR37484_c2_g1_i4 P98087 CBLN2_RAT 1.00E-07 GO:0005615; GO:0051965 extracellular space; positive regulation of synapse assembly IPR001073; IPR008983; Cerebellin-2 (Cerebellin-like protein) Cbln2 Rattus norvegicus (Rat) TR37485_c0_g1_i2 Q8N0W4 NLGNX_HUMAN 1.00E-53 GO:0003360; GO:0007155; GO:0030054; GO:0009986; GO:0045216; GO:0021549; GO:0031404; GO:0030425; GO:0060076; GO:0005887; GO:0090394; GO:0042043; GO:0035265; GO:0014069; GO:0045211; GO:0097105; GO:0042803; GO:0004872; GO:0035176; GO:0071625 Q63373 brainstem development; cell adhesion; cell junction; cell surface; cell-cell junction organization; cerebellum development; chloride ion binding; dendrite; excitatory synapse; integral to plasma membrane; negative regulation of excitatory postsynaptic membrane potential; neurexin family protein binding; organ growth; postsynaptic density; postsynaptic membrane; presynaptic membrane assembly; protein homodimerization activity; receptor activity; social behavior; vocalization behavior IPR002018; IPR019819; IPR000460; "Neuroligin-4, X-linked (Neuroligin X) (HNLX)" NLGN4X KIAA1260 NLGN4 UNQ365/PRO701 Homo sapiens (Human) TR37485_c0_g1_i5 Q9NZ94 NLGN3_HUMAN 4.00E-37 GO:0048675; GO:0050839; GO:0030054; GO:0009986; GO:0030139; GO:0060076; GO:0005887; GO:0042043; GO:0007158; GO:2000969; GO:2000463; GO:0051965; GO:0051968; GO:0097104; GO:0097105; GO:0004872; GO:0006898; GO:2000310; GO:0061001; GO:0060080; GO:1900271; GO:0002087; GO:2000331; GO:0060024; GO:0035176; GO:0008542 "axon extension; cell adhesion molecule binding; cell junction; cell surface; endocytic vesicle; excitatory synapse; integral to plasma membrane; neurexin family protein binding; neuron cell-cell adhesion; positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; positive regulation of excitatory postsynaptic membrane potential; positive regulation of synapse assembly; positive regulation of synaptic transmission, glutamatergic; postsynaptic membrane assembly; presynaptic membrane assembly; receptor activity; receptor-mediated endocytosis; regulation of N-methyl-D-aspartate selective glutamate receptor activity; regulation of dendritic spine morphogenesis; regulation of inhibitory postsynaptic membrane potential; regulation of long-term synaptic potentiation; regulation of respiratory gaseous exchange by neurological system process; regulation of terminal button organization; rhythmic synaptic transmission; social behavior; visual learning" IPR002018; IPR019819; IPR000460; Neuroligin-3 (Gliotactin homolog) NLGN3 KIAA1480 NL3 Homo sapiens (Human) TR37487_c2_g1_i1 Q92072 DNMT1_CHICK 3.00E-83 GO:0003886; GO:0003677; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "DNA (cytosine-5-)-methyltransferase activity; DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001025; IPR018117; IPR001525; IPR022702; IPR010506; IPR017198; IPR002857; DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (DNA methyltransferase GgaI) (DNA MTase GgaI) (M.GgaI) (MCMT) DNMT1 AIM DNMT Gallus gallus (Chicken) TR37487_c3_g1_i1 Q9Z330 DNMT1_RAT 2.00E-54 GO:0051718; GO:0010424; GO:0046498; GO:0046499; GO:0046500; GO:0016568; GO:0003690; GO:0010216; GO:0008327; GO:0005634; GO:0043234; GO:0006355; GO:0006351; GO:0045322; GO:0008270 "DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates; DNA methylation on cytosine within a CG sequence; S-adenosylhomocysteine metabolic process; S-adenosylmethioninamine metabolic process; S-adenosylmethionine metabolic process; chromatin modification; double-stranded DNA binding; maintenance of DNA methylation; methyl-CpG binding; nucleus; protein complex; regulation of transcription, DNA-dependent; transcription, DNA-dependent; unmethylated CpG binding; zinc ion binding" IPR001025; IPR018117; IPR001525; IPR022702; IPR010506; IPR017198; IPR002857; DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (DNA MTase RnoIP) (M.RnoIP) (DNA methyltransferase I) (MCMT) Dnmt1 Rattus norvegicus (Rat) TR37488_c4_g4_i2 Q5QQ53 XYLT_DROPS 1.00E-10 GO:0042732; GO:0000139; GO:0008375; GO:0030206; GO:0050650; GO:0005789; GO:0015012; GO:0016021; GO:0030158 D-xylose metabolic process; Golgi membrane; acetylglucosaminyltransferase activity; chondroitin sulfate biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process; endoplasmic reticulum membrane; heparan sulfate proteoglycan biosynthetic process; integral to membrane; protein xylosyltransferase activity IPR003406; IPR002889; IPR024448; Glycan metabolism; chondroitin sulfate biosynthesis. Glycan metabolism; heparan sulfate biosynthesis. Xylosyltransferase oxt (EC 2.4.2.26) (Peptide O-xylosyltransferase) oxt xt GA16815 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR3749_c1_g1_i1 P70195 PSB7_MOUSE 9.00E-34 GO:0005829; GO:0005634; GO:0005839; GO:0051603; GO:0004298 cytosol; nucleus; proteasome core complex; proteolysis involved in cellular protein catabolic process; threonine-type endopeptidase activity IPR000243; IPR024689; IPR016050; IPR001353; IPR023333; Proteasome subunit beta type-7 (EC 3.4.25.1) (Macropain chain Z) (Multicatalytic endopeptidase complex chain Z) (Proteasome subunit Z) Psmb7 Mmc14 Mus musculus (Mouse) TR37492_c0_g1_i1 Q9CXT7 TM192_MOUSE 7.00E-17 GO:0016021; GO:0005770; GO:0005765 integral to membrane; late endosome; lysosomal membrane Transmembrane protein 192 Tmem192 Mus musculus (Mouse) TR37492_c0_g1_i2 Q6NYE7 TM192_DANRE 4.00E-18 GO:0016021; GO:0005770; GO:0005765 integral to membrane; late endosome; lysosomal membrane Transmembrane protein 192 tmem192 zgc:77068 Danio rerio (Zebrafish) (Brachydanio rerio) TR37493_c5_g1_i1 Q4R794 S35F5_MACFA 2.00E-98 GO:0016021; GO:0006810 integral to membrane; transport IPR000620; Solute carrier family 35 member F5 SLC35F5 QtsA-15855 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR37494_c1_g2_i1 Q02984 RL27_PYRST 2.00E-40 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR005824; IPR014722; IPR001141; IPR018262; IPR008991; 60S ribosomal protein L27 RPL27 Pyrobotrys stellata (Green alga) (Chlamydobotrys stellata) TR37494_c1_g2_i2 Q9XSU7 RL27_CANFA 2.00E-57 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR005824; IPR014722; IPR001141; IPR018262; IPR008991; 60S ribosomal protein L27 RPL27 B173 Canis familiaris (Dog) (Canis lupus familiaris) TR37495_c1_g1_i1 O95861 BPNT1_HUMAN 4.00E-113 GO:0008441; GO:0050427; GO:0005829; GO:0004441; GO:0000287; GO:0007399; GO:0046854; GO:0006805 "3'(2'),5'-bisphosphate nucleotidase activity; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; cytosol; inositol-1,4-bisphosphate 1-phosphatase activity; magnesium ion binding; nervous system development; phosphatidylinositol phosphorylation; xenobiotic metabolic process" IPR020583; IPR000760; IPR020550; "3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (Bisphosphate 3'-nucleotidase 1) (PAP-inositol 1,4-phosphatase) (PIP)" BPNT1 Homo sapiens (Human) TR37495_c1_g1_i2 O95861 BPNT1_HUMAN 3.00E-58 GO:0008441; GO:0050427; GO:0005829; GO:0004441; GO:0000287; GO:0007399; GO:0046854; GO:0006805 "3'(2'),5'-bisphosphate nucleotidase activity; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; cytosol; inositol-1,4-bisphosphate 1-phosphatase activity; magnesium ion binding; nervous system development; phosphatidylinositol phosphorylation; xenobiotic metabolic process" IPR020583; IPR000760; IPR020550; "3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (Bisphosphate 3'-nucleotidase 1) (PAP-inositol 1,4-phosphatase) (PIP)" BPNT1 Homo sapiens (Human) TR37497_c0_g1_i1 P92973 CCA1_ARATH 8.00E-08 GO:0003682; GO:0007623; GO:0048574; GO:0042754; GO:0045892; GO:0005634; GO:0045893; GO:0043496; GO:0009737; GO:0009733; GO:0046686; GO:0009409; GO:0009723; GO:0009739; GO:0009753; GO:0010243; GO:0009751; GO:0009651; GO:0043565; GO:0003700; GO:0006351 Q08467; P40228; O81275 "chromatin binding; circadian rhythm; long-day photoperiodism, flowering; negative regulation of circadian rhythm; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of transcription, DNA-dependent; regulation of protein homodimerization activity; response to abscisic acid stimulus; response to auxin stimulus; response to cadmium ion; response to cold; response to ethylene stimulus; response to gibberellin stimulus; response to jasmonic acid stimulus; response to organonitrogen compound; response to salicylic acid stimulus; response to salt stress; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR009057; IPR017930; IPR006447; IPR001005; Protein CCA1 (MYB-related transcription factor CCA1) (Protein CIRCADIAN CLOCK ASSOCIATED 1) CCA1 At2g46830 F19D11 Arabidopsis thaliana (Mouse-ear cress) TR37497_c1_g1_i1 A0JMR6 MYSM1_XENLA 6.00E-132 GO:0003677; GO:0003682; GO:0006338; GO:0042393; GO:0046872; GO:0008237; GO:0035522; GO:0005634; GO:0045944; GO:0006508; GO:0003713; GO:0006351; GO:0004221; GO:0004843 "DNA binding; chromatin binding; chromatin remodeling; histone binding; metal ion binding; metallopeptidase activity; monoubiquitinated histone H2A deubiquitination; nucleus; positive regulation of transcription from RNA polymerase II promoter; proteolysis; transcription coactivator activity; transcription, DNA-dependent; ubiquitin thiolesterase activity; ubiquitin-specific protease activity" IPR009057; IPR000555; IPR001005; IPR017884; IPR007526; IPR011991; "Histone H2A deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1)" mysm1 Xenopus laevis (African clawed frog) TR37498_c5_g1_i4 Q6EV69 OFUT1_PANTR 1.00E-86 GO:0007219; GO:0001525; GO:0005783; GO:0006004; GO:0008417; GO:0007507; GO:0016020; GO:0007399; GO:0046922; GO:0006493; GO:0001756 Notch signaling pathway; angiogenesis; endoplasmic reticulum; fucose metabolic process; fucosyltransferase activity; heart development; membrane; nervous system development; peptide-O-fucosyltransferase activity; protein O-linked glycosylation; somitogenesis IPR019378; Protein modification; protein glycosylation. GDP-fucose protein O-fucosyltransferase 1 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 1) (O-FucT-1) POFUT1 FUT12 Pan troglodytes (Chimpanzee) TR37499_c0_g2_i1 Q64464 CP3AD_MOUSE 5.00E-83 GO:0070330; GO:0005789; GO:0020037; GO:0005506; GO:0004497; GO:0010628 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity; positive regulation of gene expression IPR001128; IPR017972; IPR008072; IPR002402; Cytochrome P450 3A13 (EC 1.14.14.1) (CYPIIIA13) Cyp3a13 Cyp3a-13 Mus musculus (Mouse) TR37499_c0_g2_i3 P63717 CP138_MYCTU 7.00E-10 GO:0020037; GO:0005506; GO:0004497; GO:0016705 "heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Putative cytochrome P450 138 (EC 1.14.-.-) cyp138 Rv0136 MT0144 MTCI5.10 Mycobacterium tuberculosis TR37501_c1_g1_i1 Q8FTE3 ARC_COREF 2.00E-25 GO:0005524; GO:0016887; GO:0019941; GO:0010498; GO:0000502 ATP binding; ATPase activity; modification-dependent protein catabolic process; proteasomal protein catabolic process; proteasome complex IPR003593; IPR003959; IPR003960; IPR027417; IPR022482; AAA ATPase forming ring-shaped complexes (ARC) arc CE1626 Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) TR37501_c2_g1_i1 Q6PL18 ATAD2_HUMAN 6.00E-99 GO:0005524; GO:0006200; GO:0016887; GO:0005634; GO:0006355; GO:0006351 "ATP binding; ATP catabolic process; ATPase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003593; IPR011989; IPR003959; IPR003960; IPR001487; IPR027417; ATPase family AAA domain-containing protein 2 (EC 3.6.1.3) (AAA nuclear coregulator cancer-associated protein) (ANCCA) ATAD2 L16 PRO2000 Homo sapiens (Human) TR37501_c5_g1_i1 Q5RKH1 PRP4B_RAT 1.00E-180 GO:0005524; GO:0008380; GO:0071013; GO:0005694; GO:0006397; GO:0004674 ATP binding; RNA splicing; catalytic step 2 spliceosome; chromosome; mRNA processing; protein serine/threonine kinase activity IPR011009; IPR000719; IPR002290; IPR008271; Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre-mRNA-processing factor 4 homolog) Prpf4b Rattus norvegicus (Rat) TR37501_c5_g1_i2 Q4R945 TTK_MACFA 6.00E-06 GO:0005524; GO:0018108; GO:0004674; GO:0004712; GO:0004713 ATP binding; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity IPR027084; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity protein kinase TTK (EC 2.7.12.1) TTK QtsA-10742 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR37501_c5_g1_i6 Q5RKH1 PRP4B_RAT 0 GO:0005524; GO:0008380; GO:0071013; GO:0005694; GO:0006397; GO:0004674 ATP binding; RNA splicing; catalytic step 2 spliceosome; chromosome; mRNA processing; protein serine/threonine kinase activity IPR011009; IPR000719; IPR002290; IPR008271; Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre-mRNA-processing factor 4 homolog) Prpf4b Rattus norvegicus (Rat) TR37502_c0_g1_i1 P07872 ACOX1_RAT 0 GO:0003995; GO:0033540; GO:0005504; GO:0050660; GO:0006091; GO:0016401; GO:0005777; GO:0006693 acyl-CoA dehydrogenase activity; fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid binding; flavin adenine dinucleotide binding; generation of precursor metabolites and energy; palmitoyl-CoA oxidase activity; peroxisome; prostaglandin metabolic process IPR006091; IPR012258; IPR002655; IPR009075; IPR013786; IPR009100; Lipid metabolism; peroxisomal fatty acid beta-oxidation. "Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain]" Acox1 Acox Rattus norvegicus (Rat) TR37502_c0_g1_i3 Q54GQ6 ACOX1_DICDI 2.00E-26 GO:0003995; GO:0003997; GO:0006635; GO:0019395; GO:0050660; GO:0006091; GO:0005777; GO:0006693 acyl-CoA dehydrogenase activity; acyl-CoA oxidase activity; fatty acid beta-oxidation; fatty acid oxidation; flavin adenine dinucleotide binding; generation of precursor metabolites and energy; peroxisome; prostaglandin metabolic process IPR006091; IPR012258; IPR002655; IPR009075; IPR013786; IPR009100; Peroxisomal acyl-coenzyme A oxidase 1 (EC 1.3.3.6) acox1 DDB_G0289993 Dictyostelium discoideum (Slime mold) TR37502_c0_g1_i5 Q8HYL8 ACOX1_PHACI 4.00E-98 GO:0003995; GO:0003997; GO:0033540; GO:0019395; GO:0050660; GO:0006091; GO:0005777; GO:0006693 acyl-CoA dehydrogenase activity; acyl-CoA oxidase activity; fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid oxidation; flavin adenine dinucleotide binding; generation of precursor metabolites and energy; peroxisome; prostaglandin metabolic process IPR006091; IPR012258; IPR002655; IPR009075; IPR013786; IPR009100; Lipid metabolism; peroxisomal fatty acid beta-oxidation. Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) ACOX1 Phascolarctos cinereus (Koala) TR37504_c0_g2_i2 Q28146 NRX1A_BOVIN 2.00E-06 GO:0007155; GO:0030054; GO:0016021; GO:0046872; GO:0007269; GO:0051965; GO:0090129; GO:0042734; GO:0007416 cell adhesion; cell junction; integral to membrane; metal ion binding; neurotransmitter secretion; positive regulation of synapse assembly; positive regulation of synapse maturation; presynaptic membrane; synapse assembly IPR008985; IPR013320; IPR000742; IPR000152; IPR001791; IPR003585; IPR027158; IPR027789; Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) NRXN1 Bos taurus (Bovine) TR37504_c0_g3_i1 Q96NU0 CNT3B_HUMAN 1.00E-07 GO:0007155; GO:0016021 cell adhesion; integral to membrane IPR000421; IPR008985; IPR013320; IPR000742; IPR014716; IPR002181; IPR008979; IPR001791; Contactin-associated protein-like 3B (Cell recognition molecule Caspr3b) CNTNAP3B CASPR3B Homo sapiens (Human) TR37506_c0_g1_i2 Q9VRV7 PM14_DROME 1.00E-65 GO:0071013; GO:0003729; GO:0000398; GO:0007052; GO:0048812; GO:0000166; GO:0071011 "catalytic step 2 spliceosome; mRNA binding; mRNA splicing, via spliceosome; mitotic spindle organization; neuron projection morphogenesis; nucleotide binding; precatalytic spliceosome" IPR012677; IPR000504; Pre-mRNA branch site p14-like protein CG13298 Drosophila melanogaster (Fruit fly) TR37506_c0_g1_i3 P59708 PM14_MOUSE 2.00E-63 GO:0003723; GO:0008380; GO:0006397; GO:0000166; GO:0005634 RNA binding; RNA splicing; mRNA processing; nucleotide binding; nucleus IPR012677; IPR000504; Pre-mRNA branch site protein p14 (SF3b 14 kDa subunit) Sf3b14 Mus musculus (Mouse) TR37507_c1_g2_i1 Q17232 OAR_BOMMO 7.00E-18 GO:0016021; GO:0004989; GO:0005886 integral to membrane; octopamine receptor activity; plasma membrane IPR000276; IPR017452; IPR002002; Octopamine receptor Bombyx mori (Silk moth) TR37507_c1_g2_i2 Q17232 OAR_BOMMO 6.00E-18 GO:0016021; GO:0004989; GO:0005886 integral to membrane; octopamine receptor activity; plasma membrane IPR000276; IPR017452; IPR002002; Octopamine receptor Bombyx mori (Silk moth) TR37508_c0_g1_i1 Q99638 RAD9A_HUMAN 4.00E-85 GO:0008408; GO:0000077; GO:0006281; GO:0006260; GO:0000076; GO:0071479; GO:0030896; GO:0005737; GO:0008853; GO:0005654; GO:0043065 O60921; O60671 3'-5' exonuclease activity; DNA damage checkpoint; DNA repair; DNA replication; DNA replication checkpoint; cellular response to ionizing radiation; checkpoint clamp complex; cytoplasm; exodeoxyribonuclease III activity; nucleoplasm; positive regulation of apoptotic process IPR026584; IPR007268; Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) RAD9A Homo sapiens (Human) TR37510_c0_g1_i5 Q6N075 MFSD5_HUMAN 8.00E-103 GO:0016021; GO:0006810 integral to membrane; transport IPR008509; IPR016196; Molybdate-anion transporter (Major facilitator superfamily domain-containing protein 5) (Molybdate transporter 2 homolog) (hsMOT2) MFSD5 UNQ832/PRO1759 Homo sapiens (Human) TR37511_c0_g1_i1 P49189 AL9A1_HUMAN 0 GO:0033737; GO:0004028; GO:0047105; GO:0019145; GO:0045329; GO:0006081; GO:0005829; GO:0042445; GO:0005739; GO:0042136; GO:0005886 1-pyrroline dehydrogenase activity; 3-chloroallyl aldehyde dehydrogenase activity; 4-trimethylammoniobutyraldehyde dehydrogenase activity; aminobutyraldehyde dehydrogenase activity; carnitine biosynthetic process; cellular aldehyde metabolic process; cytosol; hormone metabolic process; mitochondrion; neurotransmitter biosynthetic process; plasma membrane IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Amine and polyamine biosynthesis; carnitine biosynthesis. 4-trimethylaminobutyraldehyde dehydrogenase (TMABADH) (EC 1.2.1.47) (Aldehyde dehydrogenase E3 isozyme) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3) (Gamma-aminobutyraldehyde dehydrogenase) (EC 1.2.1.19) (R-aminobutyraldehyde dehydrogenase) ALDH9A1 ALDH4 ALDH7 ALDH9 Homo sapiens (Human) TR37511_c0_g1_i2 P49189 AL9A1_HUMAN 0 GO:0033737; GO:0004028; GO:0047105; GO:0019145; GO:0045329; GO:0006081; GO:0005829; GO:0042445; GO:0005739; GO:0042136; GO:0005886 1-pyrroline dehydrogenase activity; 3-chloroallyl aldehyde dehydrogenase activity; 4-trimethylammoniobutyraldehyde dehydrogenase activity; aminobutyraldehyde dehydrogenase activity; carnitine biosynthetic process; cellular aldehyde metabolic process; cytosol; hormone metabolic process; mitochondrion; neurotransmitter biosynthetic process; plasma membrane IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Amine and polyamine biosynthesis; carnitine biosynthesis. 4-trimethylaminobutyraldehyde dehydrogenase (TMABADH) (EC 1.2.1.47) (Aldehyde dehydrogenase E3 isozyme) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3) (Gamma-aminobutyraldehyde dehydrogenase) (EC 1.2.1.19) (R-aminobutyraldehyde dehydrogenase) ALDH9A1 ALDH4 ALDH7 ALDH9 Homo sapiens (Human) TR37511_c0_g1_i3 A6W2P7 BETB_MARMS 5.00E-176 GO:0008802; GO:0019285; GO:0046872 betaine-aldehyde dehydrogenase activity; glycine betaine biosynthetic process from choline; metal ion binding IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR011264; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. NAD/NADP-dependent betaine aldehyde dehydrogenase (BADH) (EC 1.2.1.8) betB Mmwyl1_4080 Marinomonas sp. (strain MWYL1) TR37511_c0_g1_i4 Q8VXQ7 GAPN_SCEVA 1.00E-27 GO:0005737; GO:0008886 cytoplasm; glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9) (Glyceraldehyde-3-phosphate dehydrogenase [NADP(+)]) (GAPDHN) (Non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase) (Triosephosphate dehydrogenase) (Fragment) GapN Scenedesmus vacuolatus (Chlorella fusca var. vacuolata) TR37511_c0_g1_i5 A7N2Q0 BETB_VIBHB 3.00E-163 GO:0008802; GO:0019285; GO:0046872 betaine-aldehyde dehydrogenase activity; glycine betaine biosynthetic process from choline; metal ion binding IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR011264; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. NAD/NADP-dependent betaine aldehyde dehydrogenase (BADH) (EC 1.2.1.8) betB VIBHAR_06180 Vibrio campbellii (strain ATCC BAA-1116 / BB120) TR37512_c7_g3_i1 Q5VV41 ARHGG_HUMAN 4.00E-67 GO:0005089; GO:0032864; GO:0032863; GO:0097190; GO:0060326; GO:0005829; GO:0048011; GO:0005543; GO:0043065; GO:0090004; GO:0007264 Rho guanyl-nucleotide exchange factor activity; activation of Cdc42 GTPase activity; activation of Rac GTPase activity; apoptotic signaling pathway; cell chemotaxis; cytosol; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of apoptotic process; positive regulation of establishment of protein localization to plasma membrane; small GTPase mediated signal transduction IPR000219; IPR011993; IPR001849; IPR001452; Rho guanine nucleotide exchange factor 16 (Ephexin-4) ARHGEF16 EPHEXIN4 NBR Homo sapiens (Human) TR37512_c7_g3_i3 Q5BKC9 NGEF_RAT 4.00E-16 GO:0005089; GO:0005737; GO:0048013; GO:0030426; GO:0016020; GO:0061002; GO:0005543; GO:0043087; GO:0035023 Rho guanyl-nucleotide exchange factor activity; cytoplasm; ephrin receptor signaling pathway; growth cone; membrane; negative regulation of dendritic spine morphogenesis; phospholipid binding; regulation of GTPase activity; regulation of Rho protein signal transduction IPR000219; IPR011993; IPR001849; IPR001452; Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor) Ngef Rattus norvegicus (Rat) TR37515_c1_g3_i2 P11456 MPRD_BOVIN 5.00E-23 GO:0009986; GO:0005768; GO:0016021; GO:0005770; GO:0005765; GO:0005537; GO:0015578 cell surface; endosome; integral to membrane; late endosome; lysosomal membrane; mannose binding; mannose transmembrane transporter activity IPR009011; IPR000296; Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46) M6PR Bos taurus (Bovine) TR37516_c8_g1_i1 Q6V0K7 OIT3_RAT 5.00E-13 GO:0005635 nuclear envelope IPR000742; IPR001507; Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein) Oit3 Lzp Rattus norvegicus (Rat) TR37517_c0_g1_i1 H2A0M7 PLSP_PINMG 1.00E-53 GO:0005576; GO:0020037; GO:0004601; GO:0006979 extracellular region; heme binding; peroxidase activity; response to oxidative stress IPR010255; IPR002007; IPR019791; Peroxidase-like protein Pinctada margaritifera (Black-lipped pearl oyster) TR37517_c0_g1_i3 H2A0M7 PLSP_PINMG 6.00E-55 GO:0005576; GO:0020037; GO:0004601; GO:0006979 extracellular region; heme binding; peroxidase activity; response to oxidative stress IPR010255; IPR002007; IPR019791; Peroxidase-like protein Pinctada margaritifera (Black-lipped pearl oyster) TR37518_c0_g1_i1 Q09575 YRD6_CAEEL 6.00E-06 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR37518_c4_g2_i1 P04146 COPIA_DROME 7.00E-27 GO:0005524; GO:0015074; GO:0004190; GO:0003676; GO:0006508; GO:0008270 ATP binding; DNA integration; aspartic-type endopeptidase activity; nucleic acid binding; proteolysis; zinc ion binding IPR025724; IPR001584; IPR012337; IPR013103; IPR001878; Copia protein (Gag-int-pol protein) [Cleaved into: Copia VLP protein; Copia protease (EC 3.4.23.-)] GIP COPIA Drosophila melanogaster (Fruit fly) TR37518_c4_g2_i3 O13527 YA11B_YEAST 7.00E-12 GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0003964; GO:0005737; GO:0046872; GO:0008233; GO:0000943; GO:0004523; GO:0004540; GO:0032197 "DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-directed DNA polymerase activity; cytoplasm; metal ion binding; peptidase activity; retrotransposon nucleocapsid; ribonuclease H activity; ribonuclease activity; transposition, RNA-mediated" IPR001584; IPR012337; IPR013103; Truncated transposon Ty1-A Gag-Pol polyprotein (TY1B) (Transposon Ty1 TYB polyprotein) [Cleaved into: Integrase (IN) (Pol-p71) (p84) (p90); Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (Pol-p63) (p60)] TY1B-A YARCTy1-1 POL YAR009C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR37518_c7_g1_i1 A2AV25 FBCD1_MOUSE 3.00E-23 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 Fibcd1 Mus musculus (Mouse) TR37519_c3_g3_i2 Q4V898 RBMX_RAT 1.00E-18 GO:0071013; GO:0071347; GO:0003682; GO:0001047; GO:0070062; GO:0003729; GO:0006376; GO:0006509; GO:0005719; GO:0000166; GO:0045944; GO:0045893; GO:0000381; GO:0003727; GO:0005681; GO:0044530; GO:0006366 "catalytic step 2 spliceosome; cellular response to interleukin-1; chromatin binding; core promoter binding; extracellular vesicular exosome; mRNA binding; mRNA splice site selection; membrane protein ectodomain proteolysis; nuclear euchromatin; nucleotide binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of alternative mRNA splicing, via spliceosome; single-stranded RNA binding; spliceosomal complex; supraspliceosomal complex; transcription from RNA polymerase II promoter" IPR012677; IPR012604; IPR000504; "RNA-binding motif protein, X chromosome (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) (RNA-binding motif protein, X chromosome retrogene) (RNA-binding motif protein, X chromosome retrogene-like) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]" Rbmx Rbmxrt Rattus norvegicus (Rat) TR37519_c3_g3_i3 A1D4K4 PABP_NEOFI 5.00E-08 GO:0003723; GO:0005737; GO:0006397; GO:0051028; GO:0000166; GO:0005634; GO:0006417 RNA binding; cytoplasm; mRNA processing; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR012677; IPR006515; IPR002004; IPR000504; "Polyadenylate-binding protein, cytoplasmic and nuclear (PABP) (Poly(A)-binding protein) (Polyadenylate tail-binding protein)" pab1 NFIA_020550 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) TR37519_c3_g3_i4 Q6BI95 PABP_DEBHA 9.00E-12 GO:0003723; GO:0005737; GO:0006397; GO:0051028; GO:0000166; GO:0005634; GO:0006417 RNA binding; cytoplasm; mRNA processing; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR012677; IPR006515; IPR002004; IPR000504; "Polyadenylate-binding protein, cytoplasmic and nuclear (PABP) (Poly(A)-binding protein) (Polyadenylate tail-binding protein)" PAB1 DEHA2G12474g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR37519_c3_g3_i6 Q4V898 RBMX_RAT 2.00E-24 GO:0071013; GO:0071347; GO:0003682; GO:0001047; GO:0070062; GO:0003729; GO:0006376; GO:0006509; GO:0005719; GO:0000166; GO:0045944; GO:0045893; GO:0000381; GO:0003727; GO:0005681; GO:0044530; GO:0006366 "catalytic step 2 spliceosome; cellular response to interleukin-1; chromatin binding; core promoter binding; extracellular vesicular exosome; mRNA binding; mRNA splice site selection; membrane protein ectodomain proteolysis; nuclear euchromatin; nucleotide binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of alternative mRNA splicing, via spliceosome; single-stranded RNA binding; spliceosomal complex; supraspliceosomal complex; transcription from RNA polymerase II promoter" IPR012677; IPR012604; IPR000504; "RNA-binding motif protein, X chromosome (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) (RNA-binding motif protein, X chromosome retrogene) (RNA-binding motif protein, X chromosome retrogene-like) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]" Rbmx Rbmxrt Rattus norvegicus (Rat) TR37524_c2_g1_i1 P18851 GBB_YEAST 1.00E-52 GO:0005834; GO:0031684; GO:0001403; GO:0005937; GO:0000750; GO:0010525; GO:0004871 P39010; P08539; P18852; Q03497; P32917 "heterotrimeric G-protein complex; heterotrimeric G-protein complex cycle; invasive growth in response to glucose limitation; mating projection; pheromone-dependent signal transduction involved in conjugation with cellular fusion; regulation of transposition, RNA-mediated; signal transducer activity" IPR020472; IPR001632; IPR016346; IPR015943; IPR001680; IPR019775; IPR017986; Guanine nucleotide-binding protein subunit beta STE4 YOR212W YOR50-2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR37524_c2_g1_i2 Q5GIS3 GBB_PINFU 0 GO:0005737; GO:0004871 cytoplasm; signal transducer activity IPR020472; IPR001632; IPR016346; IPR015943; IPR001680; IPR019775; IPR017986; Guanine nucleotide-binding protein subunit beta (pfGbeta1) (G protein subunit beta-1) Pinctada fucata (Pearl oyster) TR37527_c2_g1_i1 Q9ESN6 TRIM2_MOUSE 6.00E-12 GO:0005737; GO:0017022; GO:0043523; GO:0004842; GO:0008270 cytoplasm; myosin binding; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) TR37527_c2_g1_i2 A5D7F8 SH3R1_BOVIN 7.00E-07 GO:0005794; GO:0005829; GO:0030027; GO:0016874; GO:0043066; GO:0043154; GO:2001237; GO:0048471; GO:0016567; GO:0008270 Golgi apparatus; cytosol; lamellipodium; ligase activity; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; perinuclear region of cytoplasm; protein ubiquitination; zinc ion binding IPR000108; IPR001452; IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase SH3RF1 (EC 6.3.2.-) (Plenty of SH3s) (Protein POSH) (SH3 domain-containing RING finger protein 1) SH3RF1 POSH Bos taurus (Bovine) TR37527_c3_g1_i1 P49791 NU153_RAT 3.00E-15 GO:0003677; GO:0051028; GO:0046832; GO:0042405; GO:0005652; GO:0031965; GO:0051292; GO:0044615; GO:0005487; GO:0043495; GO:0015031; GO:0017056; GO:0008270 DNA binding; mRNA transport; negative regulation of RNA export from nucleus; nuclear inclusion body; nuclear lamina; nuclear membrane; nuclear pore complex assembly; nuclear pore nuclear basket; nucleocytoplasmic transporter activity; protein anchor; protein transport; structural constituent of nuclear pore; zinc ion binding IPR026054; IPR013913; IPR018892; IPR001876; Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) Nup153 Rattus norvegicus (Rat) TR37527_c3_g1_i2 P49792 RBP2_HUMAN 7.00E-42 GO:0008536; GO:0005975; GO:0019221; GO:0005829; GO:0015758; GO:0016874; GO:0051028; GO:0007077; GO:0042405; GO:0031965; GO:0044615; GO:0003755; GO:0006457; GO:0006606; GO:0000413; GO:0016925; GO:0010827; GO:0044281; GO:0055085; GO:0016032; GO:0008270 P04626; O60260; Q53GG5 Ran GTPase binding; carbohydrate metabolic process; cytokine-mediated signaling pathway; cytosol; glucose transport; ligase activity; mRNA transport; mitotic nuclear envelope disassembly; nuclear inclusion body; nuclear membrane; nuclear pore nuclear basket; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein import into nucleus; protein peptidyl-prolyl isomerization; protein sumoylation; regulation of glucose transport; small molecule metabolic process; transmembrane transport; viral process; zinc ion binding IPR002130; IPR020892; IPR022011; IPR011993; IPR000156; IPR013026; IPR011990; IPR001440; IPR019734; IPR001876; Protein modification; protein sumoylation. E3 SUMO-protein ligase RanBP2 (EC 6.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) RANBP2 NUP358 Homo sapiens (Human) TR37527_c3_g1_i3 P49790 NU153_HUMAN 1.00E-17 GO:0003677; GO:0005975; GO:0019221; GO:0005737; GO:0015758; GO:0051028; GO:0007077; GO:0019048; GO:0046832; GO:0042405; GO:0031965; GO:0034399; GO:0051292; GO:0044615; GO:0005487; GO:0005730; GO:0005654; GO:0043495; GO:0015031; GO:0010827; GO:0044281; GO:0017056; GO:0055085; GO:0046718; GO:0075732; GO:0016032; GO:0008270 Itself; P29323; Q16539-3 DNA binding; carbohydrate metabolic process; cytokine-mediated signaling pathway; cytoplasm; glucose transport; mRNA transport; mitotic nuclear envelope disassembly; modulation by virus of host morphology or physiology; negative regulation of RNA export from nucleus; nuclear inclusion body; nuclear membrane; nuclear periphery; nuclear pore complex assembly; nuclear pore nuclear basket; nucleocytoplasmic transporter activity; nucleolus; nucleoplasm; protein anchor; protein transport; regulation of glucose transport; small molecule metabolic process; structural constituent of nuclear pore; transmembrane transport; viral entry into host cell; viral penetration into host nucleus; viral process; zinc ion binding IPR026054; IPR013913; IPR018892; IPR001876; Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) NUP153 Homo sapiens (Human) TR37528_c1_g1_i1 Q61074 PPM1G_MOUSE 3.00E-80 GO:0007050; GO:0046872; GO:0005634; GO:0035970; GO:0004721; GO:0006470; GO:0004722 cell cycle arrest; metal ion binding; nucleus; peptidyl-threonine dephosphorylation; phosphoprotein phosphatase activity; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; Protein phosphatase 1G (EC 3.1.3.16) (Fibroblast growth factor-inducible protein 13) (FIN13) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) Ppm1g Fin13 Ppm1c Mus musculus (Mouse) TR37528_c3_g1_i1 Q7K4Q5 Y0417_DROME 1.00E-44 GO:0046872; GO:0006470; GO:0004722 metal ion binding; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; Probable protein phosphatase CG10417 (EC 3.1.3.16) CG10417 Drosophila melanogaster (Fruit fly) TR37528_c4_g1_i2 Q92172 TEF_CHICK 5.00E-46 GO:0003677; GO:0005634; GO:0045944; GO:0043565; GO:0003700; GO:0006351 "DNA binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; Transcription factor VBP (Thyrotroph embryonic factor homolog) (Vitellogenin gene-binding protein) TEF VBP Gallus gallus (Chicken) TR37528_c4_g1_i3 Q64709 HLF_RAT 8.00E-54 GO:0005634; GO:0048511; GO:0043565; GO:0003700; GO:0006351 "nucleus; rhythmic process; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; Hepatic leukemia factor Hlf Rattus norvegicus (Rat) TR37529_c2_g1_i1 P43240 AGTR1_CANFA 3.00E-07 GO:0004945; GO:0016021; GO:0005886; GO:0019229 angiotensin type II receptor activity; integral to membrane; plasma membrane; regulation of vasoconstriction IPR000190; IPR000248; IPR000276; IPR017452; Type-1 angiotensin II receptor (Angiotensin II type-1 receptor) (AT1) AGTR1 Canis familiaris (Dog) (Canis lupus familiaris) TR37529_c2_g1_i2 P70031 CCKAR_XENLA 4.00E-07 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR009126; IPR000276; IPR017452; Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) TR37531_c0_g2_i1 Q6QBQ4 PLS3_RAT 8.00E-10 GO:0006915; GO:0071222; GO:0016021; GO:0031966 apoptotic process; cellular response to lipopolysaccharide; integral to membrane; mitochondrial membrane IPR005552; Phospholipid scramblase 3 (PL scramblase 3) (Ca(2+)-dependent phospholipid scramblase 3) Plscr3 Pls3 Rattus norvegicus (Rat) TR37531_c0_g2_i2 Q9NRY6 PLS3_HUMAN 9.00E-06 GO:0006915; GO:0005509; GO:0071222; GO:0042632; GO:0042593; GO:0016021; GO:0031966; GO:0017128; GO:0005886 O75340 apoptotic process; calcium ion binding; cellular response to lipopolysaccharide; cholesterol homeostasis; glucose homeostasis; integral to membrane; mitochondrial membrane; phospholipid scramblase activity; plasma membrane IPR005552; Phospholipid scramblase 3 (PL scramblase 3) (Ca(2+)-dependent phospholipid scramblase 3) PLSCR3 Homo sapiens (Human) TR37532_c0_g1_i1 Q568R1 NSRP1_DANRE 9.00E-37 IPR018612; Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) nsrp1 ccdc55 wu:fc14d05 zgc:152777 Danio rerio (Zebrafish) (Brachydanio rerio) TR37532_c0_g1_i2 Q568R1 NSRP1_DANRE 2.00E-23 IPR018612; Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) nsrp1 ccdc55 wu:fc14d05 zgc:152777 Danio rerio (Zebrafish) (Brachydanio rerio) TR37534_c0_g2_i2 P22411 DPP4_PIG 3.00E-151 GO:0042110; GO:0031295; GO:0004177; GO:0016324; GO:0007155; GO:0009986; GO:0008239; GO:0030139; GO:0043542; GO:0070062; GO:0016021; GO:0046581; GO:0071438; GO:0030027; GO:0031258; GO:0045121; GO:0010716; GO:0008284; GO:0002020; GO:0042803; GO:0006508; GO:0005102; GO:0033632; GO:0001666; GO:0004252 T cell activation; T cell costimulation; aminopeptidase activity; apical plasma membrane; cell adhesion; cell surface; dipeptidyl-peptidase activity; endocytic vesicle; endothelial cell migration; extracellular vesicular exosome; integral to membrane; intercellular canaliculus; invadopodium membrane; lamellipodium; lamellipodium membrane; membrane raft; negative regulation of extracellular matrix disassembly; positive regulation of cell proliferation; protease binding; protein homodimerization activity; proteolysis; receptor binding; regulation of cell-cell adhesion mediated by integrin; response to hypoxia; serine-type endopeptidase activity IPR002471; IPR001375; IPR002469; Dipeptidyl peptidase 4 (EC 3.4.14.5) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)] DPP4 CD26 Sus scrofa (Pig) TR37534_c0_g2_i3 Q8N608 DPP10_HUMAN 4.00E-141 GO:0016021; GO:0016020; GO:0006508; GO:0008236 integral to membrane; membrane; proteolysis; serine-type peptidase activity IPR001375; IPR002469; Inactive dipeptidyl peptidase 10 (Dipeptidyl peptidase IV-related protein 3) (DPRP-3) (Dipeptidyl peptidase X) (DPP X) (Dipeptidyl peptidase-like protein 2) (DPL2) DPP10 DPRP3 KIAA1492 Homo sapiens (Human) TR37535_c1_g4_i1 Q6P0Q8 MAST2_HUMAN 0 GO:0005524; GO:0005737; GO:0000287; GO:0015630; GO:0005886; GO:0006468; GO:0004674; GO:0045075; GO:0048515 Q9BYE9; P48764; Q28362 ATP binding; cytoplasm; magnesium ion binding; microtubule cytoskeleton; plasma membrane; protein phosphorylation; protein serine/threonine kinase activity; regulation of interleukin-12 biosynthetic process; spermatid differentiation IPR000961; IPR011009; IPR015022; IPR023142; IPR001478; IPR000719; IPR002290; IPR008271; Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) MAST2 KIAA0807 MAST205 Homo sapiens (Human) TR37536_c3_g1_i1 Q5RAE3 LAT2_PONAB 5.00E-158 GO:0015171; GO:0016323; GO:0005737; GO:0016021 amino acid transmembrane transporter activity; basolateral plasma membrane; cytoplasm; integral to membrane IPR002293; IPR004760; Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (Solute carrier family 7 member 8) SLC7A8 LAT2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37536_c3_g1_i2 Q8MH63 LAT1N_HUMAN 5.00E-38 GO:0015171; GO:0016021 amino acid transmembrane transporter activity; integral to membrane IPR002293; Putative L-type amino acid transporter 1-like protein MLAS (hLAT1 3-transmembrane protein MLAS) (hLAT1 3TM MLAS) SLC7A5P1 MLAS Homo sapiens (Human) TR37538_c0_g1_i1 C3Y431 DDRGK_BRAFL 1.00E-43 IPR019153; DDRGK domain-containing protein 1 BRAFLDRAFT_114851 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR37539_c2_g5_i1 Q5RAS7 AMMR1_PONAB 2.00E-66 IPR023473; IPR002733; IPR027485; AMME syndrome candidate gene 1 protein homolog AMMECR1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37539_c2_g6_i1 Q5RDQ3 AMERL_PONAB 7.00E-39 IPR023473; IPR002733; IPR027485; AMMECR1-like protein AMMECR1L Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37540_c0_g3_i1 B5X165 SMG9_SALSA 2.00E-103 GO:0000184 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" IPR019354; Protein SMG9 (Protein smg-9 homolog) smg9 Salmo salar (Atlantic salmon) TR37540_c0_g3_i2 B5DDX6 SMG9_XENTR 2.00E-98 GO:0000184 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" IPR027417; IPR019354; Protein SMG9 (Protein smg-9 homolog) smg9 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37541_c4_g1_i1 Q9H0R3 TM222_HUMAN 2.00E-77 GO:0016021 integral to membrane IPR008496; Transmembrane protein 222 TMEM222 C1orf160 Homo sapiens (Human) TR37542_c1_g1_i2 Q5PPZ5 BIN3_XENLA 5.00E-50 GO:0000917; GO:0005737; GO:0005856 barrier septum assembly; cytoplasm; cytoskeleton IPR027267; IPR004148; Bridging integrator 3 homolog bin3 Xenopus laevis (African clawed frog) TR37543_c2_g1_i1 Q3T0D6 LEG4_BOVIN 1.00E-33 GO:0030246 carbohydrate binding IPR008985; IPR013320; IPR015533; IPR001079; Galectin-4 (Gal-4) LGALS4 Bos taurus (Bovine) TR37544_c2_g1_i1 P70187 HIAT1_MOUSE 0 GO:0016021; GO:0005886; GO:0055085; GO:0005215 integral to membrane; plasma membrane; transmembrane transport; transporter activity IPR011701; IPR020846; IPR016196; IPR005829; IPR001958; Hippocampus abundant transcript 1 protein Hiat1 Mus musculus (Mouse) TR37546_c0_g1_i1 Q10977 PPSA_MYCTU 6.00E-71 GO:0004316; GO:0004315; GO:0000036; GO:0071770; GO:0005618; GO:0097041; GO:0031177; GO:0097040; GO:0034081 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process; DIM/DIP cell wall layer assembly; cell wall; phenolic phthiocerol biosynthetic process; phosphopantetheine binding; phthiocerol biosynthetic process; polyketide synthase complex IPR001227; IPR009081; IPR014043; IPR016035; IPR002198; IPR018201; IPR014031; IPR014030; IPR016036; IPR016040; IPR020842; IPR020801; IPR020841; IPR020806; IPR006162; IPR016039; IPR016038; Lipid metabolism; fatty acid biosynthesis. Phthiocerol synthesis polyketide synthase type I PpsA (Beta-ketoacyl-acyl-carrier-protein synthase I) (EC 2.3.1.41) ppsA Rv2931 MT3000 MTCY338.20 Mycobacterium tuberculosis TR37546_c2_g2_i1 A7Z4X9 BAED_BACA2 9.00E-24 GO:0017000; GO:0005737; GO:0016746 "antibiotic biosynthetic process; cytoplasm; transferase activity, transferring acyl groups" IPR001227; IPR014043; IPR016035; IPR016036; Antibiotic biosynthesis; bacillaene biosynthesis. Polyketide biosynthesis acyltransferase homolog BaeD (AT) (EC 2.3.1.-) (Transacylase) baeD RBAM_016920 Bacillus amyloliquefaciens (strain FZB42) TR37546_c3_g3_i1 O68006 BACA_BACLI 4.00E-06 GO:0017000; GO:0008881; GO:0016874 antibiotic biosynthetic process; glutamate racemase activity; ligase activity IPR010071; IPR009081; IPR025110; IPR020845; IPR000873; IPR001242; IPR013624; IPR010060; IPR006162; Antibiotic biosynthesis; bacitracin biosynthesis. Bacitracin synthase 1 (BA1) [Includes: ATP-dependent cysteine adenylase (CysA) (Cysteine activase); ATP-dependent leucine adenylase (LeuA) (Leucine activase); ATP-dependent glutamate adenylase (GluA) (Glutamate activase); ATP-dependent isoleucine adenylase (IleA) (Isoleucine activase); Glutamate racemase (EC 5.1.1.3)] bacA Bacillus licheniformis TR37546_c3_g3_i2 Q03131 ERYA1_SACER 1.00E-12 GO:0017000; GO:0047879; GO:0031177 antibiotic biosynthetic process; erythronolide synthase activity; phosphopantetheine binding IPR001227; IPR009081; IPR014043; IPR016035; IPR018201; IPR014031; IPR014030; IPR016036; IPR016040; IPR020842; IPR020801; IPR020841; IPR013968; IPR020806; IPR006162; IPR016039; IPR016038; Antibiotic biosynthesis; erythromycin biosynthesis. "Erythronolide synthase, modules 1 and 2 (EC 2.3.1.94) (6-deoxyerythronolide B synthase I) (DEBS 1) (ORF 1)" eryA Saccharopolyspora erythraea (Streptomyces erythraeus) TR37547_c1_g1_i3 Q24040 BGB_DROME 6.00E-54 GO:0005634; GO:0046982; GO:0035206; GO:0006357; GO:0003713; GO:0008134 nucleus; protein heterodimerization activity; regulation of hemocyte proliferation; regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcription factor binding IPR003417; Protein big brother Bgb CG7959 Drosophila melanogaster (Fruit fly) TR37547_c1_g1_i4 Q13951 PEBB_HUMAN 4.00E-61 GO:0003677; GO:0048469; GO:0060216; GO:0030098; GO:0030099; GO:0005634; GO:0001649; GO:0045944; GO:0003700; GO:0003713; GO:0006366 Q9NVM9; P11137; Q01196; P12504 DNA binding; cell maturation; definitive hemopoiesis; lymphocyte differentiation; myeloid cell differentiation; nucleus; osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription from RNA polymerase II promoter IPR003417; Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit) CBFB Homo sapiens (Human) TR37549_c0_g1_i1 Q7LHG5 YI31B_YEAST 3.00E-07 GO:0005524; GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0005737; GO:0008233; GO:0006508; GO:0000943; GO:0004523; GO:0004540; GO:0032197; GO:0046797; GO:0008270 "ATP binding; DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; cytoplasm; peptidase activity; proteolysis; retrotransposon nucleocapsid; ribonuclease H activity; ribonuclease activity; transposition, RNA-mediated; viral procapsid maturation; zinc ion binding" IPR001584; IPR024650; IPR021109; IPR005162; IPR012337; IPR000477; IPR001878; Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR37549_c3_g1_i2 Q6INU7 FRRS1_XENLA 1.00E-48 GO:0016021; GO:0016491 integral to membrane; oxidoreductase activity IPR006593; IPR005018; IPR002861; Putative ferric-chelate reductase 1 (EC 1.-.-.-) frrs1 Xenopus laevis (African clawed frog) TR37550_c1_g1_i1 Q8NB50 ZFP62_HUMAN 4.00E-12 GO:0046872; GO:0003676; GO:0005634; GO:0006355; GO:0006351 "metal ion binding; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 62 homolog (Zfp-62) ZFP62 Homo sapiens (Human) TR37550_c10_g1_i1 A6QPT6 ZN274_BOVIN 4.00E-10 GO:0005813; GO:0005737; GO:0046872; GO:0005166; GO:0005730; GO:0005634; GO:0043565; GO:0000981 centrosome; cytoplasm; metal ion binding; neurotrophin p75 receptor binding; nucleolus; nucleus; sequence-specific DNA binding; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Neurotrophin receptor-interacting factor homolog (Zinc finger protein 274) ZNF274 Bos taurus (Bovine) TR37550_c10_g2_i1 O60304 ZN500_HUMAN 1.00E-13 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein 500 (Zinc finger protein with KRAB and SCAN domains 18) ZNF500 KIAA0557 ZKSCAN18 Homo sapiens (Human) TR37550_c10_g5_i1 Q8WVZ9 KBTB7_HUMAN 2.00E-07 O95166; Q9H0R8; P60520; Q9GZQ8; Q9BXW4 IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch repeat and BTB domain-containing protein 7 KBTBD7 Homo sapiens (Human) TR37551_c1_g1_i1 Q08705 CTCF_CHICK 4.00E-90 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 P67809 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog) CTCF Gallus gallus (Chicken) TR37551_c1_g1_i10 Q68EA5 ZNF57_HUMAN 2.00E-51 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 57 (Zinc finger protein 424) ZNF57 ZNF424 Homo sapiens (Human) TR37551_c1_g1_i2 Q6ZSB9 ZBT49_HUMAN 4.00E-31 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR020542; IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) ZBTB49 ZNF509 Homo sapiens (Human) TR37551_c1_g1_i3 Q6ZSB9 ZBT49_HUMAN 4.00E-31 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR020542; IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) ZBTB49 ZNF509 Homo sapiens (Human) TR37551_c1_g1_i4 Q10096 YAOH_SCHPO 9.00E-07 GO:0003677; GO:0005634; GO:0006355; GO:0003700; GO:0006351; GO:0008270 "DNA binding; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR027775; IPR007219; IPR007087; IPR015880; IPR013087; Zinc finger protein C11D3.17 SPAC11D3.17 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR37551_c1_g1_i6 Q63HK3 ZKSC2_HUMAN 8.00E-26 GO:0003677; GO:0003682; GO:0046872; GO:0005634; GO:0000981 DNA binding; chromatin binding; metal ion binding; nucleus; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR001909; IPR008916; IPR001005; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein with KRAB and SCAN domains 2 (Zinc finger protein 694) ZKSCAN2 ZNF694 Homo sapiens (Human) TR37551_c1_g1_i8 Q08705 CTCF_CHICK 4.00E-90 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 P67809 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog) CTCF Gallus gallus (Chicken) TR37551_c1_g1_i9 Q08705 CTCF_CHICK 4.00E-90 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 P67809 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog) CTCF Gallus gallus (Chicken) TR37551_c1_g2_i1 Q03172 ZEP1_MOUSE 2.00E-06 GO:0003677; GO:0046872; GO:0000122; GO:0005634; GO:0006351 P63085 "DNA binding; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 40 (Alpha A-crystallin-binding protein 1) (Alpha A-CRYBP1) (Alpha A-crystallin-binding protein I) (Transcription factor alphaA-CRYBP1) Hivep1 Cryabp1 Znf40 Mus musculus (Mouse) TR37552_c0_g1_i2 Q9JKN6 NOVA1_MOUSE 3.00E-09 GO:0003729; GO:0000398; GO:0005634 "mRNA binding; mRNA splicing, via spliceosome; nucleus" IPR004087; IPR004088; RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Ventral neuron-specific protein 1) Nova1 Mus musculus (Mouse) TR37552_c1_g1_i1 Q96I24 FUBP3_HUMAN 8.00E-68 GO:0003677; GO:0003723; GO:0005737; GO:0005634; GO:0045893; GO:0006351 "DNA binding; RNA binding; cytoplasm; nucleus; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR004087; IPR004088; Far upstream element-binding protein 3 (FUSE-binding protein 3) FUBP3 FBP3 Homo sapiens (Human) TR37553_c0_g1_i1 P65810 PEPE_MYCTU 1.00E-16 GO:0009987; GO:0016787; GO:0016021; GO:0046872; GO:0005886 cellular process; hydrolase activity; integral to membrane; metal ion binding; plasma membrane IPR000587; IPR000994; IPR001131; Probable dipeptidase PepE (EC 3.4.13.-) pepE Rv2089c MT2150 MTCY49.29c Mycobacterium tuberculosis TR37553_c0_g2_i2 Q9NQW7 XPP1_HUMAN 0 GO:0010815; GO:0005737; GO:0005829; GO:0030145; GO:0070006; GO:0006508 bradykinin catabolic process; cytoplasm; cytosol; manganese ion binding; metalloaminopeptidase activity; proteolysis IPR000587; IPR000994; IPR001131; "Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble)" XPNPEP1 XPNPEPL XPNPEPL1 Homo sapiens (Human) TR37553_c0_g2_i4 Q9NQW7 XPP1_HUMAN 1.00E-180 GO:0010815; GO:0005737; GO:0005829; GO:0030145; GO:0070006; GO:0006508 bradykinin catabolic process; cytoplasm; cytosol; manganese ion binding; metalloaminopeptidase activity; proteolysis IPR000587; IPR000994; IPR001131; "Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble)" XPNPEP1 XPNPEPL XPNPEPL1 Homo sapiens (Human) TR37554_c0_g1_i1 Q20296 HDA6_CAEEL 9.00E-24 GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0070932; GO:0070933; GO:0005634; GO:0033558; GO:0006355; GO:0006351; GO:0008270 "NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone H3 deacetylation; histone H4 deacetylation; nucleus; protein deacetylase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR000286; IPR023801; IPR013083; IPR001607; Histone deacetylase 6 (EC 3.5.1.98) hda-6 F41H10.6 Caenorhabditis elegans TR37554_c0_g1_i3 Q9UBN7 HDAC6_HUMAN 4.00E-30 GO:0070846; GO:0051879; GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0016235; GO:0070842; GO:0043014; GO:0005901; GO:0031252; GO:0070301; GO:0071218; GO:0035967; GO:0005881; GO:0005829; GO:0070840; GO:0019899; GO:0070932; GO:0070933; GO:0004407; GO:0000118; GO:0032418; GO:0016236; GO:0005874; GO:0005875; GO:0008017; GO:0006515; GO:0010727; GO:0007026; GO:0051354; GO:0043242; GO:0045861; GO:0045892; GO:0034983; GO:0048471; GO:0031593; GO:0070845; GO:0090035; GO:0010634; GO:1901300; GO:0010870; GO:0009967; GO:0043241; GO:0000209; GO:0060765; GO:0070201; GO:0060632; GO:0010469; GO:0070848; GO:0051788; GO:0009636; GO:0048156; GO:0006351; GO:0042903; GO:0043162; GO:0008270 P21146; Q9NQ11; Q9HCU9; Q62623; Q14247; Q60598; Q9NQC7; P00533; P17252; P03409 "Hsp90 deacetylation; Hsp90 protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); aggresome; aggresome assembly; alpha-tubulin binding; caveola; cell leading edge; cellular response to hydrogen peroxide; cellular response to misfolded protein; cellular response to topologically incorrect protein; cytoplasmic microtubule; cytosol; dynein complex binding; enzyme binding; histone H3 deacetylation; histone H4 deacetylation; histone deacetylase activity; histone deacetylase complex; lysosome localization; macroautophagy; microtubule; microtubule associated complex; microtubule binding; misfolded or incompletely synthesized protein catabolic process; negative regulation of hydrogen peroxide metabolic process; negative regulation of microtubule depolymerization; negative regulation of oxidoreductase activity; negative regulation of protein complex disassembly; negative regulation of proteolysis; negative regulation of transcription, DNA-dependent; peptidyl-lysine deacetylation; perinuclear region of cytoplasm; polyubiquitin binding; polyubiquitinated misfolded protein transport; positive regulation of chaperone-mediated protein complex assembly; positive regulation of epithelial cell migration; positive regulation of hydrogen peroxide-mediated programmed cell death; positive regulation of receptor biosynthetic process; positive regulation of signal transduction; protein complex disassembly; protein polyubiquitination; regulation of androgen receptor signaling pathway; regulation of establishment of protein localization; regulation of microtubule-based movement; regulation of receptor activity; response to growth factor stimulus; response to misfolded protein; response to toxic substance; tau protein binding; transcription, DNA-dependent; tubulin deacetylase activity; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; zinc ion binding" IPR000286; IPR023801; IPR013083; IPR001607; Histone deacetylase 6 (HD6) (EC 3.5.1.98) HDAC6 KIAA0901 JM21 Homo sapiens (Human) TR37554_c0_g1_i4 Q9UBN7 HDAC6_HUMAN 2.00E-30 GO:0070846; GO:0051879; GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0016235; GO:0070842; GO:0043014; GO:0005901; GO:0031252; GO:0070301; GO:0071218; GO:0035967; GO:0005881; GO:0005829; GO:0070840; GO:0019899; GO:0070932; GO:0070933; GO:0004407; GO:0000118; GO:0032418; GO:0016236; GO:0005874; GO:0005875; GO:0008017; GO:0006515; GO:0010727; GO:0007026; GO:0051354; GO:0043242; GO:0045861; GO:0045892; GO:0034983; GO:0048471; GO:0031593; GO:0070845; GO:0090035; GO:0010634; GO:1901300; GO:0010870; GO:0009967; GO:0043241; GO:0000209; GO:0060765; GO:0070201; GO:0060632; GO:0010469; GO:0070848; GO:0051788; GO:0009636; GO:0048156; GO:0006351; GO:0042903; GO:0043162; GO:0008270 P21146; Q9NQ11; Q9HCU9; Q62623; Q14247; Q60598; Q9NQC7; P00533; P17252; P03409 "Hsp90 deacetylation; Hsp90 protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); aggresome; aggresome assembly; alpha-tubulin binding; caveola; cell leading edge; cellular response to hydrogen peroxide; cellular response to misfolded protein; cellular response to topologically incorrect protein; cytoplasmic microtubule; cytosol; dynein complex binding; enzyme binding; histone H3 deacetylation; histone H4 deacetylation; histone deacetylase activity; histone deacetylase complex; lysosome localization; macroautophagy; microtubule; microtubule associated complex; microtubule binding; misfolded or incompletely synthesized protein catabolic process; negative regulation of hydrogen peroxide metabolic process; negative regulation of microtubule depolymerization; negative regulation of oxidoreductase activity; negative regulation of protein complex disassembly; negative regulation of proteolysis; negative regulation of transcription, DNA-dependent; peptidyl-lysine deacetylation; perinuclear region of cytoplasm; polyubiquitin binding; polyubiquitinated misfolded protein transport; positive regulation of chaperone-mediated protein complex assembly; positive regulation of epithelial cell migration; positive regulation of hydrogen peroxide-mediated programmed cell death; positive regulation of receptor biosynthetic process; positive regulation of signal transduction; protein complex disassembly; protein polyubiquitination; regulation of androgen receptor signaling pathway; regulation of establishment of protein localization; regulation of microtubule-based movement; regulation of receptor activity; response to growth factor stimulus; response to misfolded protein; response to toxic substance; tau protein binding; transcription, DNA-dependent; tubulin deacetylase activity; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; zinc ion binding" IPR000286; IPR023801; IPR013083; IPR001607; Histone deacetylase 6 (HD6) (EC 3.5.1.98) HDAC6 KIAA0901 JM21 Homo sapiens (Human) TR37554_c0_g1_i5 Q9Z2V5 HDAC6_MOUSE 4.00E-30 GO:0070846; GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0016235; GO:0070842; GO:0048487; GO:0005901; GO:0031252; GO:0070301; GO:0071218; GO:0005881; GO:0005829; GO:0030286; GO:0070932; GO:0070933; GO:0004407; GO:0000118; GO:0032418; GO:0016236; GO:0008017; GO:0006515; GO:0007026; GO:0045861; GO:0005634; GO:0034983; GO:0048471; GO:0070845; GO:0090035; GO:0010634; GO:1901300; GO:0010870; GO:0009967; GO:0043241; GO:0000209; GO:0070201; GO:0010469; GO:0006355; GO:0070848; GO:0009636; GO:0006351; GO:0042903; GO:0043130; GO:0043162; GO:0008270 P21146; Q80TQ2 "Hsp90 deacetylation; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); aggresome; aggresome assembly; beta-tubulin binding; caveola; cell leading edge; cellular response to hydrogen peroxide; cellular response to misfolded protein; cytoplasmic microtubule; cytosol; dynein complex; histone H3 deacetylation; histone H4 deacetylation; histone deacetylase activity; histone deacetylase complex; lysosome localization; macroautophagy; microtubule binding; misfolded or incompletely synthesized protein catabolic process; negative regulation of microtubule depolymerization; negative regulation of proteolysis; nucleus; peptidyl-lysine deacetylation; perinuclear region of cytoplasm; polyubiquitinated misfolded protein transport; positive regulation of chaperone-mediated protein complex assembly; positive regulation of epithelial cell migration; positive regulation of hydrogen peroxide-mediated programmed cell death; positive regulation of receptor biosynthetic process; positive regulation of signal transduction; protein complex disassembly; protein polyubiquitination; regulation of establishment of protein localization; regulation of receptor activity; regulation of transcription, DNA-dependent; response to growth factor stimulus; response to toxic substance; transcription, DNA-dependent; tubulin deacetylase activity; ubiquitin binding; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; zinc ion binding" IPR000286; IPR023801; IPR013083; IPR001607; Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Histone deacetylase mHDA2) Hdac6 Mus musculus (Mouse) TR37554_c0_g2_i1 Q6P9L4 UBP49_MOUSE 2.00E-09 GO:0004197; GO:0035616; GO:0042393; GO:0000398; GO:0005634; GO:0004221; GO:0006511; GO:0004843; GO:0008270 "cysteine-type endopeptidase activity; histone H2B conserved C-terminal lysine deubiquitination; histone binding; mRNA splicing, via spliceosome; nucleus; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity; zinc ion binding" IPR018200; IPR001394; IPR013083; IPR001607; Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.4.19.12) (Deubiquitinating enzyme 49) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49) Usp49 Mus musculus (Mouse) TR37555_c1_g1_i1 O88879 APAF_MOUSE 1.00E-10 GO:0043531; GO:0005524; GO:0005794; GO:0008635; GO:0006309; GO:0008656; GO:0005829; GO:0006952; GO:0030900; GO:0001843; GO:0051402; GO:0005634; GO:2001235 ADP binding; ATP binding; Golgi apparatus; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; apoptotic DNA fragmentation; cysteine-type endopeptidase activator activity involved in apoptotic process; cytosol; defense response; forebrain development; neural tube closure; neuron apoptotic process; nucleus; positive regulation of apoptotic signaling pathway IPR017251; IPR001315; IPR011029; IPR000767; IPR020472; IPR002182; IPR027417; IPR015943; IPR001680; IPR019775; IPR017986; Apoptotic protease-activating factor 1 (APAF-1) Apaf1 Mus musculus (Mouse) TR37555_c1_g1_i2 C3XVT5 LIS1_BRAFL 2.00E-08 GO:0051301; GO:0006928; GO:0005737; GO:0000132; GO:0005874; GO:0005875; GO:0005815; GO:0007067; GO:0006810 cell division; cellular component movement; cytoplasm; establishment of mitotic spindle orientation; microtubule; microtubule associated complex; microtubule organizing center; mitosis; transport IPR017252; IPR020472; IPR006594; IPR013720; IPR015943; IPR001680; IPR019775; IPR017986; Lissencephaly-1 homolog BRAFLDRAFT_59218 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR37555_c2_g1_i1 O75717 WDHD1_HUMAN 2.00E-172 GO:0003677; GO:0003723; GO:0006396; GO:0003682; GO:0000775; GO:0005737; GO:0070829; GO:0005654; GO:0033044 Q92830 "DNA binding; RNA binding; RNA processing; chromatin binding; chromosome, centromeric region; cytoplasm; heterochromatin maintenance; nucleoplasm; regulation of chromosome organization" IPR022100; IPR009071; IPR013979; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) WDHD1 AND1 Homo sapiens (Human) TR37558_c0_g1_i1 P97603 NEO1_RAT 1.00E-09 GO:0007155; GO:0016021; GO:0005886 cell adhesion; integral to membrane; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR010560; Neogenin (Fragment) Neo1 Ngn Rattus norvegicus (Rat) TR37558_c1_g1_i1 P98160 PGBM_HUMAN 4.00E-27 GO:0005796; GO:0001525; GO:0005605; GO:0007420; GO:0005975; GO:0048738; GO:0060351; GO:0002062; GO:0030204; GO:0048704; GO:0001958; GO:0030198; GO:0005615; GO:0070062; GO:0006024; GO:0006027; GO:0042157; GO:0043202; GO:0046872; GO:0007603; GO:0005886; GO:0008104; GO:0001523 P35968 "Golgi lumen; angiogenesis; basal lamina; brain development; carbohydrate metabolic process; cardiac muscle tissue development; cartilage development involved in endochondral bone morphogenesis; chondrocyte differentiation; chondroitin sulfate metabolic process; embryonic skeletal system morphogenesis; endochondral ossification; extracellular matrix organization; extracellular space; extracellular vesicular exosome; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; lipoprotein metabolic process; lysosomal lumen; metal ion binding; phototransduction, visible light; plasma membrane; protein localization; retinoid metabolic process" IPR008985; IPR013320; IPR000742; IPR013032; IPR002049; IPR007110; IPR013783; IPR013098; IPR003598; IPR018031; IPR000034; IPR001791; IPR023415; IPR002172; IPR000082; Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] HSPG2 Homo sapiens (Human) TR37558_c2_g1_i1 Q3V1M1 IGS10_MOUSE 9.00E-21 GO:0005576; GO:0001503 extracellular region; ossification IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Immunoglobulin superfamily member 10 (IgSF10) Igsf10 Mus musculus (Mouse) TR37560_c0_g1_i1 Q46C63 RFCS_METBF 1.00E-76 GO:0005524; GO:0003689; GO:0006260; GO:0005663 ATP binding; DNA clamp loader activity; DNA replication; DNA replication factor C complex IPR003593; IPR003959; IPR008921; IPR027417; IPR023748; IPR013748; Replication factor C small subunit (RFC small subunit) (Clamp loader small subunit) rfcS Mbar_A1582 Methanosarcina barkeri (strain Fusaro / DSM 804) TR37560_c0_g1_i3 Q641W4 RFC2_RAT 0 GO:0005524; GO:0003677; GO:0006260; GO:0005663; GO:0017111; GO:0005634 ATP binding; DNA binding; DNA replication; DNA replication factor C complex; nucleoside-triphosphatase activity; nucleus IPR003593; IPR003959; IPR008921; IPR027417; IPR013748; Replication factor C subunit 2 (Activator 1 subunit C2) Rfc2 Rattus norvegicus (Rat) TR37561_c0_g1_i1 A6H782 TEKT3_BOVIN 9.00E-122 GO:0035085; GO:0005874; GO:0000226 cilium axoneme; microtubule; microtubule cytoskeleton organization IPR000435; Tektin-3 TEKT3 Bos taurus (Bovine) TR37561_c0_g1_i3 A6H782 TEKT3_BOVIN 2.00E-121 GO:0035085; GO:0005874; GO:0000226 cilium axoneme; microtubule; microtubule cytoskeleton organization IPR000435; Tektin-3 TEKT3 Bos taurus (Bovine) TR37563_c1_g1_i1 Q9CZT6 CC026_MOUSE 2.00E-47 IPR027417; Protein CMSS1 (Cms1 ribosomal small subunit homolog) Cmss1 Mus musculus (Mouse) TR37563_c1_g1_i3 Q9CZT6 CC026_MOUSE 4.00E-48 IPR027417; Protein CMSS1 (Cms1 ribosomal small subunit homolog) Cmss1 Mus musculus (Mouse) TR37564_c0_g1_i2 Q2TBI0 LBP_BOVIN 4.00E-61 GO:0042742; GO:0005576; GO:0008289; GO:0006869 defense response to bacterium; extracellular region; lipid binding; lipid transport IPR017943; IPR001124; IPR017954; IPR017942; Lipopolysaccharide-binding protein (LBP) LBP Bos taurus (Bovine) TR37566_c1_g1_i2 Q5EAK8 DRAM1_XENTR 6.00E-14 GO:0006915; GO:0006914; GO:0016021; GO:0005765 apoptotic process; autophagy; integral to membrane; lysosomal membrane IPR027315; IPR019402; DNA damage-regulated autophagy modulator protein 1 (Damage-regulated autophagy modulator) dram1 dram Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37566_c1_g1_i3 Q5EAK8 DRAM1_XENTR 6.00E-14 GO:0006915; GO:0006914; GO:0016021; GO:0005765 apoptotic process; autophagy; integral to membrane; lysosomal membrane IPR027315; IPR019402; DNA damage-regulated autophagy modulator protein 1 (Damage-regulated autophagy modulator) dram1 dram Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37566_c1_g1_i5 Q9DC58 DRAM1_MOUSE 1.00E-10 GO:0030262; GO:0006914; GO:0016021; GO:0005765 apoptotic nuclear changes; autophagy; integral to membrane; lysosomal membrane IPR027315; IPR019402; DNA damage-regulated autophagy modulator protein 1 (Damage-regulated autophagy modulator) Dram1 Dram Mus musculus (Mouse) TR37567_c0_g1_i2 Q99L00 HAUS8_MOUSE 2.00E-06 GO:0070652; GO:0051301; GO:0005813; GO:0051297; GO:0005737; GO:0005874; GO:0007067; GO:0051225; GO:0000922 HAUS complex; cell division; centrosome; centrosome organization; cytoplasm; microtubule; mitosis; spindle assembly; spindle pole HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48 homolog) Haus8 Hice1 Mus musculus (Mouse) TR37567_c0_g1_i3 Q9BT25 HAUS8_HUMAN 1.00E-10 GO:0070652; GO:0051301; GO:0005813; GO:0051297; GO:0005737; GO:0005874; GO:0007067; GO:0051225; GO:0000922 HAUS complex; cell division; centrosome; centrosome organization; cytoplasm; microtubule; mitosis; spindle assembly; spindle pole HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) HAUS8 HICE1 Homo sapiens (Human) TR37567_c0_g1_i4 Q9BT25 HAUS8_HUMAN 2.00E-10 GO:0070652; GO:0051301; GO:0005813; GO:0051297; GO:0005737; GO:0005874; GO:0007067; GO:0051225; GO:0000922 HAUS complex; cell division; centrosome; centrosome organization; cytoplasm; microtubule; mitosis; spindle assembly; spindle pole HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) HAUS8 HICE1 Homo sapiens (Human) TR37567_c0_g1_i5 Q99L00 HAUS8_MOUSE 2.00E-06 GO:0070652; GO:0051301; GO:0005813; GO:0051297; GO:0005737; GO:0005874; GO:0007067; GO:0051225; GO:0000922 HAUS complex; cell division; centrosome; centrosome organization; cytoplasm; microtubule; mitosis; spindle assembly; spindle pole HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48 homolog) Haus8 Hice1 Mus musculus (Mouse) TR37569_c0_g1_i4 Q9WVM7 AIMP2_CRIGR 2.00E-33 GO:0006915; GO:0030154; GO:0005829; GO:0007275; GO:0005634; GO:0006412 apoptotic process; cell differentiation; cytosol; multicellular organismal development; nucleus; translation IPR010987; Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1) AIMP2 JTV1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR37570_c4_g4_i1 O88477 IF2B1_MOUSE 1.00E-10 GO:0070937; GO:0070934; GO:0030424; GO:0010494; GO:0043197; GO:0030175; GO:0030426; GO:0030027; GO:0003730; GO:0048027; GO:0051028; GO:0017148; GO:0000166; GO:0005634; GO:0048471; GO:0005886; GO:0010610; GO:0045182 CRD-mediated mRNA stability complex; CRD-mediated mRNA stabilization; axon; cytoplasmic stress granule; dendritic spine; filopodium; growth cone; lamellipodium; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA transport; negative regulation of translation; nucleotide binding; nucleus; perinuclear region of cytoplasm; plasma membrane; regulation of mRNA stability involved in response to stress; translation regulator activity IPR004087; IPR004088; IPR012677; IPR000504; Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1) Igf2bp1 Vickz1 Mus musculus (Mouse) TR37570_c4_g4_i2 Q9Y2W6 TDRKH_HUMAN 3.00E-72 GO:0043046; GO:0003723; GO:0030154; GO:0009566; GO:0031047; GO:0007140; GO:0005739; GO:0071546; GO:0071547; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; RNA binding; cell differentiation; fertilization; gene silencing by RNA; male meiosis; mitochondrion; pi-body; piP-body; piRNA metabolic process; spermatogenesis IPR004087; IPR004088; IPR002999; Tudor and KH domain-containing protein (Tudor domain-containing protein 2) TDRKH TDRD2 Homo sapiens (Human) TR37570_c4_g4_i4 Q58EK5 TDRD1_DANRE 4.00E-13 GO:0043046; GO:0031047; GO:0007281; GO:0007126; GO:0046872; GO:0007275; GO:0071546; GO:0034587; GO:0007283 Q8UVX0; A2CEI6 DNA methylation involved in gamete generation; gene silencing by RNA; germ cell development; meiosis; metal ion binding; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002999; IPR002893; Tudor domain-containing protein 1 tdrd1 im:7155161 Danio rerio (Zebrafish) (Brachydanio rerio) TR37570_c4_g4_i6 Q91WJ8 FUBP1_MOUSE 1.00E-14 GO:0003677; GO:0003723; GO:0001205; GO:0005634 DNA binding; RNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; nucleus IPR015096; IPR004087; IPR004088; Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) Fubp1 D3Ertd330e Mus musculus (Mouse) TR37572_c2_g1_i1 Q7Z3S7 CA2D4_HUMAN 3.00E-09 GO:0005262; GO:0016021; GO:0046872; GO:0005244 calcium channel activity; integral to membrane; metal ion binding; voltage-gated ion channel activity IPR004010; IPR013608; IPR002035; Voltage-dependent calcium channel subunit alpha-2/delta-4 (Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4] CACNA2D4 Homo sapiens (Human) TR37572_c2_g2_i1 Q5VU97 CAHD1_HUMAN 2.00E-73 GO:0006816; GO:0016021 calcium ion transport; integral to membrane IPR004010; IPR013608; IPR002035; VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) CACHD1 KIAA1573 VWCD1 Homo sapiens (Human) TR37575_c0_g1_i2 Q8RA32 DPO3_THETN 3.00E-06 GO:0008408; GO:0003677; GO:0006260; GO:0003887; GO:0005737; GO:0090305 3'-5' exonuclease activity; DNA binding; DNA replication; DNA-directed DNA polymerase activity; cytoplasm; nucleic acid phosphodiester bond hydrolysis IPR011708; IPR024754; IPR023223; IPR006054; IPR006055; IPR013520; IPR012340; IPR004013; IPR003141; IPR006308; IPR012337; DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC TTE1398 Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis) TR37575_c0_g1_i3 Q8RA32 DPO3_THETN 4.00E-06 GO:0008408; GO:0003677; GO:0006260; GO:0003887; GO:0005737; GO:0090305 3'-5' exonuclease activity; DNA binding; DNA replication; DNA-directed DNA polymerase activity; cytoplasm; nucleic acid phosphodiester bond hydrolysis IPR011708; IPR024754; IPR023223; IPR006054; IPR006055; IPR013520; IPR012340; IPR004013; IPR003141; IPR006308; IPR012337; DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC TTE1398 Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis) TR37577_c1_g1_i2 Q4KLT3 TRM44_XENLA 1.00E-145 GO:0005737; GO:0046872; GO:0008168; GO:0008033 cytoplasm; metal ion binding; methyltransferase activity; tRNA processing IPR011671; IPR000571; Probable tRNA (uracil-O(2)-)-methyltransferase (EC 2.1.1.211) (Methyltransferase-like protein 19) trmt44 mettl19 Xenopus laevis (African clawed frog) TR37577_c1_g1_i5 Q8IYL2 TRM44_HUMAN 8.00E-126 GO:0005737; GO:0046872; GO:0008168; GO:0008033 cytoplasm; metal ion binding; methyltransferase activity; tRNA processing IPR011671; IPR000571; Probable tRNA (uracil-O(2)-)-methyltransferase (EC 2.1.1.211) (Methyltransferase-like protein 19) TRMT44 C4orf23 METTL19 Homo sapiens (Human) TR37577_c1_g1_i7 Q8IYL2 TRM44_HUMAN 8.00E-21 GO:0005737; GO:0046872; GO:0008168; GO:0008033 cytoplasm; metal ion binding; methyltransferase activity; tRNA processing IPR011671; IPR000571; Probable tRNA (uracil-O(2)-)-methyltransferase (EC 2.1.1.211) (Methyltransferase-like protein 19) TRMT44 C4orf23 METTL19 Homo sapiens (Human) TR37578_c2_g1_i1 P06867 PLMN_PIG 3.00E-15 GO:0007596; GO:0005576; GO:0042730; GO:0006508; GO:0004252; GO:0048771 blood coagulation; extracellular region; fibrinolysis; proteolysis; serine-type endopeptidase activity; tissue remodeling IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Sus scrofa (Pig) TR37579_c0_g2_i1 Q6DFF6 KLH20_XENLA 0 GO:0031463; GO:0016605; GO:0005737; GO:0019964; GO:0043066; GO:0048471; GO:0043161; GO:0004842 Cul3-RING ubiquitin ligase complex; PML body; cytoplasm; interferon-gamma binding; negative regulation of apoptotic process; perinuclear region of cytoplasm; proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 20 klhl20 Xenopus laevis (African clawed frog) TR37579_c0_g2_i2 Q5RG82 NS1BA_DANRE 7.00E-50 GO:0005737; GO:0005856; GO:0005634 cytoplasm; cytoskeleton; nucleus IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Influenza virus NS1A-binding protein homolog A (NS1-BP homolog A) (NS1-binding protein homolog A) ivns1abpa si:dkeyp-11g8.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR37580_c1_g1_i1 Q9GV72 CTX1_CARRA 7.00E-37 GO:0019835; GO:0044179; GO:0016021; GO:0006811; GO:0042151; GO:0044218 cytolysis; hemolysis in other organism; integral to membrane; ion transport; nematocyst; other organism cell membrane Toxin CrTX-A (CRT-1) (CrTX-B) (Toxin 1) Carybdea rastonii (Box jellyfish) TR37580_c1_g1_i3 A7L036 CTX2_CHIFL 4.00E-27 GO:0019835; GO:0044179; GO:0016021; GO:0006811; GO:0042151; GO:0044218 cytolysis; hemolysis in other organism; integral to membrane; ion transport; nematocyst; other organism cell membrane Toxin CfTX-2 (Toxin 2) Chironex fleckeri (Box jellyfish) TR37580_c1_g1_i5 Q9GV72 CTX1_CARRA 2.00E-25 GO:0019835; GO:0044179; GO:0016021; GO:0006811; GO:0042151; GO:0044218 cytolysis; hemolysis in other organism; integral to membrane; ion transport; nematocyst; other organism cell membrane Toxin CrTX-A (CRT-1) (CrTX-B) (Toxin 1) Carybdea rastonii (Box jellyfish) TR37581_c0_g1_i1 Q9V4M2 WECH_DROME 3.00E-06 GO:0030154; GO:0002168; GO:0005622; GO:0016203; GO:0005927; GO:0033632; GO:0008270 cell differentiation; instar larval development; intracellular; muscle attachment; muscle tendon junction; regulation of cell-cell adhesion mediated by integrin; zinc ion binding IPR011042; IPR001258; IPR013017; IPR000315; Protein wech (Protein dappled) wech dpld CG42396 Drosophila melanogaster (Fruit fly) TR37582_c0_g1_i3 P55145 MANF_HUMAN 5.00E-45 GO:0005615; GO:0048471; GO:0006986; GO:0002014 extracellular space; perinuclear region of cytoplasm; response to unfolded protein; vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure IPR019345; IPR011001; Mesencephalic astrocyte-derived neurotrophic factor (Arginine-rich protein) (Protein ARMET) MANF ARMET ARP Homo sapiens (Human) TR37583_c0_g1_i1 A8H029 TPMT_SHEPA 1.00E-13 GO:0005737; GO:0010038; GO:0008119 cytoplasm; response to metal ion; thiopurine S-methyltransferase activity IPR022474; IPR025835; IPR008854; Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) tpm Spea_0588 Shewanella pealeana (strain ATCC 700345 / ANG-SQ1) TR37583_c0_g1_i2 A1U560 TPMT_MARAV 1.00E-14 GO:0005737; GO:0010038; GO:0008119 cytoplasm; response to metal ion; thiopurine S-methyltransferase activity IPR022474; IPR025835; IPR008854; Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) tpm Maqu_3055 Marinobacter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8) (Marinobacter hydrocarbonoclasticus (strain DSM 11845)) TR37583_c0_g1_i3 Q3BCR4 TPMT_CHLAE 6.00E-39 GO:0005737; GO:0008119 cytoplasm; thiopurine S-methyltransferase activity IPR025835; IPR008854; Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) TPMT Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) TR37583_c0_g1_i6 Q5NEH3 TPMT_FRATT 6.00E-10 GO:0005737; GO:0008119 cytoplasm; thiopurine S-methyltransferase activity IPR025835; IPR008854; Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) tpm FTT_1661 Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) TR37583_c0_g1_i8 Q504A5 TPMT_DANRE 7.00E-49 GO:0005737; GO:0008119 cytoplasm; thiopurine S-methyltransferase activity IPR025835; IPR008854; Probable thiopurine S-methyltransferase (Thiopurine methyltransferase) (EC 2.1.1.67) tpmt zgc:109981 Danio rerio (Zebrafish) (Brachydanio rerio) TR37583_c0_g1_i9 Q60AQ2 TPMT_METCA 2.00E-22 GO:0005737; GO:0010038; GO:0008119 cytoplasm; response to metal ion; thiopurine S-methyltransferase activity IPR022474; IPR025835; IPR008854; Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) tpm MCA0794 Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) TR37584_c2_g1_i1 Q4R739 ANR53_MACFA 1.00E-36 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 53 ANKRD53 QtsA-16406 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR37584_c3_g1_i3 P43137 LIT1_MOUSE 4.00E-07 GO:0030246; GO:0005576; GO:0008083 carbohydrate binding; extracellular region; growth factor activity IPR001304; IPR016186; IPR018378; IPR016187; Lithostathine-1 (Islet of Langerhans regenerating protein 1) (REG 1) (Pancreatic stone protein 1) (PSP) (Pancreatic thread protein 1) (PTP) (Regenerating protein 1) Reg1 Mus musculus (Mouse) TR37585_c1_g1_i3 Q4R979 RBM4_MACFA 8.00E-32 GO:0002192; GO:0008380; GO:0030154; GO:0097167; GO:0010494; GO:0043153; GO:0003730; GO:0006397; GO:0035198; GO:0032055; GO:0035278; GO:0045947; GO:0016607; GO:0005730; GO:0000166; GO:0051149; GO:0097158; GO:0000381; GO:0046822; GO:0046685; GO:0051403; GO:0008270 "IRES-dependent translational initiation; RNA splicing; cell differentiation; circadian regulation of translation; cytoplasmic stress granule; entrainment of circadian clock by photoperiod; mRNA 3'-UTR binding; mRNA processing; miRNA binding; negative regulation of translation in response to stress; negative regulation of translation involved in gene silencing by miRNA; negative regulation of translational initiation; nuclear speck; nucleolus; nucleotide binding; positive regulation of muscle cell differentiation; pre-mRNA intronic pyrimidine-rich binding; regulation of alternative mRNA splicing, via spliceosome; regulation of nucleocytoplasmic transport; response to arsenic-containing substance; stress-activated MAPK cascade; zinc ion binding" IPR012677; IPR000504; IPR001878; RNA-binding protein 4 (RNA-binding motif protein 4) RBM4 QtsA-10585 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR37585_c1_g1_i4 Q4R979 RBM4_MACFA 6.00E-32 GO:0002192; GO:0008380; GO:0030154; GO:0097167; GO:0010494; GO:0043153; GO:0003730; GO:0006397; GO:0035198; GO:0032055; GO:0035278; GO:0045947; GO:0016607; GO:0005730; GO:0000166; GO:0051149; GO:0097158; GO:0000381; GO:0046822; GO:0046685; GO:0051403; GO:0008270 "IRES-dependent translational initiation; RNA splicing; cell differentiation; circadian regulation of translation; cytoplasmic stress granule; entrainment of circadian clock by photoperiod; mRNA 3'-UTR binding; mRNA processing; miRNA binding; negative regulation of translation in response to stress; negative regulation of translation involved in gene silencing by miRNA; negative regulation of translational initiation; nuclear speck; nucleolus; nucleotide binding; positive regulation of muscle cell differentiation; pre-mRNA intronic pyrimidine-rich binding; regulation of alternative mRNA splicing, via spliceosome; regulation of nucleocytoplasmic transport; response to arsenic-containing substance; stress-activated MAPK cascade; zinc ion binding" IPR012677; IPR000504; IPR001878; RNA-binding protein 4 (RNA-binding motif protein 4) RBM4 QtsA-10585 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR37587_c0_g2_i1 Q16960 DYI3_ANTCR 0 GO:0035085; GO:0030286; GO:0005874; GO:0003774 cilium axoneme; dynein complex; microtubule; motor activity IPR015943; IPR001680; IPR019775; IPR017986; "Dynein intermediate chain 3, ciliary" Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR37588_c3_g2_i1 Q7ZW86 CWC27_DANRE 6.00E-128 GO:0003755; GO:0006457; GO:0000413 peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR020892; Peptidyl-prolyl cis-trans isomerase CWC27 homolog (PPIase CWC27) (EC 5.2.1.8) cwc27 sdccag10 zgc:56702 Danio rerio (Zebrafish) (Brachydanio rerio) TR37588_c3_g2_i2 P0C1J2 CWC27_RHIO9 1.00E-68 GO:0008380; GO:0005737; GO:0006397; GO:0003755; GO:0006457; GO:0000413; GO:0005681 RNA splicing; cytoplasm; mRNA processing; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization; spliceosomal complex IPR002130; IPR020892; Peptidyl-prolyl isomerase cwc27 (PPIase cwc27) (EC 5.2.1.8) (Rotamase cwc27) cwc27 RO3G_04513 Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar) TR37589_c4_g1_i1 Q17R16 LHPL4_BOVIN 3.00E-12 GO:0016021 integral to membrane IPR019372; Lipoma HMGIC fusion partner-like 4 protein LHFPL4 Bos taurus (Bovine) TR37589_c4_g1_i3 Q5PRC1 LHFP_DANRE 7.00E-19 GO:0016021 integral to membrane IPR019372; Lipoma HMGIC fusion partner homolog lhfp zgc:101683 Danio rerio (Zebrafish) (Brachydanio rerio) TR3759_c0_g1_i1 Q9V6L0 KDM4B_DROME 1.00E-33 GO:0051864; GO:0032454; GO:0046872; GO:0045892; GO:0005634; GO:0006351 "histone demethylase activity (H3-K36 specific); histone demethylase activity (H3-K9 specific); metal ion binding; negative regulation of transcription, DNA-dependent; nucleus; transcription, DNA-dependent" IPR003347; IPR003349; Probable lysine-specific demethylase 4B (EC 1.14.11.-) (Probable JmjC domain-containing histone demethylation protein 3B) Kdm4B CG33182 Drosophila melanogaster (Fruit fly) TR37590_c0_g1_i1 Q9DCN1 NUD12_MOUSE 9.00E-126 GO:0019677; GO:0000210; GO:0035529; GO:0006742; GO:0046872; GO:0005634; GO:0005777 NAD catabolic process; NAD+ diphosphatase activity; NADH pyrophosphatase activity; NADP catabolic process; metal ion binding; nucleus; peroxisome IPR002110; IPR020683; IPR015375; IPR020084; IPR000086; IPR015797; IPR015376; Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12) Nudt12 Mus musculus (Mouse) TR37591_c5_g4_i2 Q1PRL4 LIN41_CHICK 5.00E-07 GO:0000082; GO:0000932; GO:0008543; GO:0035198; GO:0010586; GO:0035278; GO:0001843; GO:0021915; GO:2000637; GO:0051865; GO:0060964; GO:2000177; GO:0072089; GO:0004842; GO:0008270 G1/S transition of mitotic cell cycle; cytoplasmic mRNA processing body; fibroblast growth factor receptor signaling pathway; miRNA binding; miRNA metabolic process; negative regulation of translation involved in gene silencing by miRNA; neural tube closure; neural tube development; positive regulation of gene silencing by miRNA; protein autoubiquitination; regulation of gene silencing by miRNA; regulation of neural precursor cell proliferation; stem cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Gallus gallus (Chicken) TR37591_c5_g4_i3 Q1PSW8 LIN41_MOUSE 7.00E-14 GO:0000082; GO:0000932; GO:0008543; GO:0035198; GO:0010586; GO:0035278; GO:0001843; GO:2000637; GO:0051865; GO:2000177; GO:0072089; GO:0004842; GO:0008270 G1/S transition of mitotic cell cycle; cytoplasmic mRNA processing body; fibroblast growth factor receptor signaling pathway; miRNA binding; miRNA metabolic process; negative regulation of translation involved in gene silencing by miRNA; neural tube closure; positive regulation of gene silencing by miRNA; protein autoubiquitination; regulation of neural precursor cell proliferation; stem cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (mLin41) (Tripartite motif-containing protein 71) Trim71 Gm1127 Lin41 Mus musculus (Mouse) TR37591_c5_g4_i5 Q1PSW8 LIN41_MOUSE 7.00E-16 GO:0000082; GO:0000932; GO:0008543; GO:0035198; GO:0010586; GO:0035278; GO:0001843; GO:2000637; GO:0051865; GO:2000177; GO:0072089; GO:0004842; GO:0008270 G1/S transition of mitotic cell cycle; cytoplasmic mRNA processing body; fibroblast growth factor receptor signaling pathway; miRNA binding; miRNA metabolic process; negative regulation of translation involved in gene silencing by miRNA; neural tube closure; positive regulation of gene silencing by miRNA; protein autoubiquitination; regulation of neural precursor cell proliferation; stem cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (mLin41) (Tripartite motif-containing protein 71) Trim71 Gm1127 Lin41 Mus musculus (Mouse) TR37591_c5_g4_i7 Q8IS11 GEFO_DICDI 2.00E-06 GO:0005085; GO:0005622; GO:0051056; GO:0007264; GO:0008270 guanyl-nucleotide exchange factor activity; intracellular; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; zinc ion binding IPR000651; IPR008937; IPR023578; IPR001895; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Ras guanine nucleotide exchange factor O (RasGEF domain-containing protein O) gefO rasGEFO DDB_G0290267 Dictyostelium discoideum (Slime mold) TR37593_c1_g1_i2 Q5EA49 MIS12_BOVIN 1.00E-17 GO:0000444; GO:0051301; GO:0007059; GO:0051382; GO:0007067; GO:0005634 MIS12/MIND type complex; cell division; chromosome segregation; kinetochore assembly; mitosis; nucleus IPR008685; Protein MIS12 homolog MIS12 Bos taurus (Bovine) TR37594_c5_g2_i1 Q8R151 ZNFX1_MOUSE 1.00E-63 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR37595_c0_g1_i1 A2RVM0 TIC32_ARATH 7.00E-40 GO:0009706; GO:0016491; GO:0005886; GO:0015031 chloroplast inner membrane; oxidoreductase activity; plasma membrane; protein transport IPR002198; IPR002347; IPR016040; "Short-chain dehydrogenase TIC 32, chloroplastic (EC 1.1.1.-) (Translocon at the inner envelope membrane of chloroplasts 32) (AtTIC32)" TIC32 At4g23430 F16G20.130 Arabidopsis thaliana (Mouse-ear cress) TR37596_c0_g1_i1 Q98943 CASP2_CHICK 5.00E-24 GO:0006915; GO:0004197; GO:0005622; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; intracellular; proteolysis; regulation of apoptotic process IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) TR37596_c0_g1_i2 O08738 CASP6_MOUSE 2.00E-12 GO:0006915; GO:0004197; GO:0005829; GO:0005634; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytosol; nucleus; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11] Casp6 Mus musculus (Mouse) TR37598_c0_g2_i1 Q05187 TGMH_TACTR 1.00E-67 GO:0016020; GO:0046872; GO:0018149; GO:0003810 membrane; metal ion binding; peptide cross-linking; protein-glutamine gamma-glutamyltransferase activity IPR023608; IPR013783; IPR014756; IPR002931; IPR008958; IPR013808; IPR001102; Hemocyte protein-glutamine gamma-glutamyltransferase (EC 2.3.2.13) (Hemocyte transglutaminase) (TGase) Tachypleus tridentatus (Japanese horseshoe crab) TR37598_c0_g3_i3 P52183 ANNU_SCHAM 1.00E-79 GO:0046872; GO:0018149; GO:0005886; GO:0003810 metal ion binding; peptide cross-linking; plasma membrane; protein-glutamine gamma-glutamyltransferase activity IPR023608; IPR013783; IPR014756; IPR002931; IPR008958; IPR013808; IPR001102; Annulin (Protein-glutamine gamma-glutamyltransferase) (EC 2.3.2.13) (Transglutaminase) Schistocerca americana (American grasshopper) TR37600_c0_g1_i1 Q54IT3 AOFA_DICDI 5.00E-79 GO:0016491 oxidoreductase activity IPR002937; IPR001613; Probable flavin-containing monoamine oxidase A (EC 1.4.3.4) maoA DDB_G0288541 Dictyostelium discoideum (Slime mold) TR37603_c8_g1_i1 Q8HY82 CATS_SAIBB 3.00E-102 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin S (EC 3.4.22.27) CTSS Saimiri boliviensis boliviensis (Bolivian squirrel monkey) TR37603_c8_g2_i1 P32955 CYSP2_CARCN 1.00E-11 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR000169; IPR013128; IPR000668; Cysteine proteinase 2 (EC 3.4.22.-) (CC-II) (Cysteine proteinase II) (Fragment) Carica candamarcensis (Mountain papaya) (Vasconcellea cundinamarcensis) TR37603_c8_g2_i2 Q5NE16 CATL3_HUMAN 2.00E-11 GO:0008234 cysteine-type peptidase activity IPR013128; IPR013201; Putative inactive cathepsin L-like protein CTSL3P (Cathepsin L3 pseudogene) (HCTSL-s) CTSL3P CTSL3 Homo sapiens (Human) TR37603_c8_g3_i1 Q26636 CATL_SARPE 4.00E-108 GO:0030154; GO:0008234; GO:0005764; GO:0007275; GO:0006508 cell differentiation; cysteine-type peptidase activity; lysosome; multicellular organismal development; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) TR37603_c8_g3_i2 P09648 CATL1_CHICK 1.00E-80 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; Cathepsin L1 (EC 3.4.22.15) (Cathepsin L) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain] (Fragments) CTSL CTSL1 Gallus gallus (Chicken) TR37604_c1_g1_i2 A2AJ76 HMCN2_MOUSE 7.00E-06 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 Hmcn2 Mus musculus (Mouse) TR37604_c3_g1_i1 P31809 CEAM1_MOUSE 8.00E-16 GO:0060170; GO:0009897; GO:0007156; GO:0016021; GO:0019048; GO:0043406; GO:0009615; GO:0001618 cilium membrane; external side of plasma membrane; homophilic cell adhesion; integral to membrane; modulation by virus of host morphology or physiology; positive regulation of MAP kinase activity; response to virus; virus receptor activity IPR007110; IPR013783; IPR003598; IPR013106; IPR013151; Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a) Ceacam1 Bgp Bgp1 Bgpd Mus musculus (Mouse) TR37604_c3_g1_i2 O35136 NCAM2_MOUSE 1.00E-12 GO:0031225; GO:0030424; GO:0007155; GO:0016021; GO:0005886 anchored to membrane; axon; cell adhesion; integral to membrane; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR009138; Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2) (Neural cell adhesion molecule RB-8) (R4B12) Ncam2 Ocam Rncam Mus musculus (Mouse) TR37604_c3_g1_i3 P06731 CEAM5_HUMAN 4.00E-13 GO:0031225; GO:0016323; GO:0005887 Itself anchored to membrane; basolateral plasma membrane; integral to plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e) CEACAM5 CEA Homo sapiens (Human) TR37606_c4_g2_i4 Q4KLT6 FL2D_XENLA 5.00E-44 GO:0008380; GO:0007049; GO:0006397; GO:0005730 RNA splicing; cell cycle; mRNA processing; nucleolus Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (WT1-associated protein) (Wilms tumor 1-associating protein) wtap Xenopus laevis (African clawed frog) TR37608_c0_g2_i1 P31396 HR3_DROME 2.00E-27 GO:0000977; GO:0004879; GO:0007552; GO:0016319; GO:0000122; GO:0005634; GO:0045944; GO:0040034; GO:0003707; GO:0004887; GO:0008270 "RNA polymerase II regulatory region sequence-specific DNA binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; metamorphosis; mushroom body development; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of development, heterochronic; steroid hormone receptor activity; thyroid hormone receptor activity; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001728; IPR001628; IPR013088; Probable nuclear hormone receptor HR3 (dHR3) (Nuclear receptor subfamily 1 group F member 4) Hr46 Hr3 NR1F4 CG11823 Drosophila melanogaster (Fruit fly) TR37608_c1_g2_i1 Q1L673 VDRB_DANRE 3.00E-22 GO:0008434; GO:0005634; GO:0043565; GO:0003707; GO:0070561; GO:0008270 calcitriol receptor activity; nucleus; sequence-specific DNA binding; steroid hormone receptor activity; vitamin D receptor signaling pathway; zinc ion binding IPR008946; IPR000536; IPR001723; IPR000324; IPR001628; IPR013088; "Vitamin D3 receptor B (VDR-B) (1,25-dihydroxyvitamin D3 receptor B) (Nuclear receptor subfamily 1 group I member 1-B)" vdrb nr1i1b gb:dq017633 Danio rerio (Zebrafish) (Brachydanio rerio) TR37609_c1_g2_i1 P22735 TGM1_HUMAN 1.00E-130 GO:0043163; GO:0005913; GO:0006464; GO:0001533; GO:0031224; GO:0031424; GO:0030216; GO:0046872; GO:0009887; GO:0018149; GO:0003810 cell envelope organization; cell-cell adherens junction; cellular protein modification process; cornified envelope; intrinsic to membrane; keratinization; keratinocyte differentiation; metal ion binding; organ morphogenesis; peptide cross-linking; protein-glutamine gamma-glutamyltransferase activity IPR023608; IPR013783; IPR014756; IPR002931; IPR008958; IPR013808; IPR001102; Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) TGM1 KTG Homo sapiens (Human) TR37610_c2_g1_i1 Q5ZM33 HP1B3_CHICK 4.00E-27 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR005818; IPR011991; Heterochromatin protein 1-binding protein 3 HP1BP3 RCJMB04_3f4 Gallus gallus (Chicken) TR37610_c2_g1_i2 Q5ZM33 HP1B3_CHICK 4.00E-27 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR005818; IPR011991; Heterochromatin protein 1-binding protein 3 HP1BP3 RCJMB04_3f4 Gallus gallus (Chicken) TR37612_c4_g2_i7 Q6E2N3 TRI33_DANRE 6.00E-06 GO:0003677; GO:0016874; GO:0005634; GO:0016567; GO:0006355; GO:0006351; GO:0008270 "DNA binding; ligase activity; nucleus; protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (Protein moonshine) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 mon Danio rerio (Zebrafish) (Brachydanio rerio) TR37612_c5_g1_i2 Q924H5 RA51C_MOUSE 1.00E-135 GO:0005524; GO:0003677; GO:0006281; GO:0008094; GO:0048476; GO:0008821; GO:0007066; GO:0007141; GO:0005739; GO:0005634; GO:0048471; GO:0007131; GO:0007283 ATP binding; DNA binding; DNA repair; DNA-dependent ATPase activity; Holliday junction resolvase complex; crossover junction endodeoxyribonuclease activity; female meiosis sister chromatid cohesion; male meiosis I; mitochondrion; nucleus; perinuclear region of cytoplasm; reciprocal meiotic recombination; spermatogenesis IPR013632; IPR016467; IPR020588; IPR027417; DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2) Rad51c Rad51l2 Mus musculus (Mouse) TR37613_c0_g1_i1 Q9I926 FUCL6_ANGJA 5.00E-12 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-6 Anguilla japonica (Japanese eel) TR37613_c0_g1_i2 Q9I931 FUCL1_ANGJA 2.00E-08 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-1 Anguilla japonica (Japanese eel) TR37614_c0_g1_i2 A3KPN8 TTC38_DANRE 1.00E-173 IPR011990; Tetratricopeptide repeat protein 38 (TPR repeat protein 38) ttc38 si:ch211-249g22.2 zgc:112407 Danio rerio (Zebrafish) (Brachydanio rerio) TR37619_c1_g6_i6 Q2KIR1 SNRPA_BOVIN 1.00E-48 GO:0003723; GO:0000398; GO:0000166; GO:0017069; GO:0005681 "RNA binding; mRNA splicing, via spliceosome; nucleotide binding; snRNA binding; spliceosomal complex" IPR012677; IPR000504; IPR024888; U1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A) SNRPA Bos taurus (Bovine) TR37619_c1_g6_i9 Q2KIR1 SNRPA_BOVIN 2.00E-47 GO:0003723; GO:0000398; GO:0000166; GO:0017069; GO:0005681 "RNA binding; mRNA splicing, via spliceosome; nucleotide binding; snRNA binding; spliceosomal complex" IPR012677; IPR000504; IPR024888; U1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A) SNRPA Bos taurus (Bovine) TR3762_c0_g1_i1 P49411 EFTU_HUMAN 1.00E-131 GO:0005525; GO:0006184; GO:0003924; GO:0042645; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; mitochondrial nucleoid; translation elongation factor activity IPR000795; IPR027417; IPR009000; IPR009001; IPR004161; IPR004541; IPR004160; "Elongation factor Tu, mitochondrial (EF-Tu) (P43)" TUFM Homo sapiens (Human) TR3762_c0_g2_i1 P42473 EFTU_CHLP8 9.00E-131 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; translation elongation factor activity IPR000795; IPR027417; IPR005225; IPR009000; IPR009001; IPR004161; IPR004541; IPR004160; Elongation factor Tu (EF-Tu) tuf Cpar_0175 Chlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327)) TR37620_c1_g2_i3 Q9FK28 MEM12_ARATH 3.00E-13 GO:0000139; GO:0005795; GO:0005801; GO:0016021; GO:0015031; GO:0045088; GO:0050708 Golgi membrane; Golgi stack; cis-Golgi network; integral to membrane; protein transport; regulation of innate immune response; regulation of protein secretion IPR027027; Membrin-12 (AtMEMB12) (Golgi SNAP receptor complex member 2-2) MEMB12 At5g50440 MXI22.16 Arabidopsis thaliana (Mouse-ear cress) TR37620_c1_g2_i4 O35165 GOSR2_RAT 3.00E-71 GO:0000139; GO:0005795; GO:0005789; GO:0016021; GO:0015031; GO:0016192 Golgi membrane; Golgi stack; endoplasmic reticulum membrane; integral to membrane; protein transport; vesicle-mediated transport IPR027027; Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin) Gosr2 Gs27 Rattus norvegicus (Rat) TR37621_c0_g1_i1 Q5ZJ65 FA76A_CHICK 1.00E-72 Protein FAM76A FAM76A RCJMB04_20f16 Gallus gallus (Chicken) TR37623_c1_g1_i2 Q949S9 SPF27_ARATH 3.00E-21 GO:0008380; GO:0009870; GO:0010204; GO:0042742; GO:0050832; GO:0045087; GO:0006397; GO:0005730; GO:0005681 P92948 "RNA splicing; defense response signaling pathway, resistance gene-dependent; defense response signaling pathway, resistance gene-independent; defense response to bacterium; defense response to fungus; innate immune response; mRNA processing; nucleolus; spliceosomal complex" IPR008409; Pre-mRNA-splicing factor SPF27 homolog (Modifier of SNC1 member 4) (Protein BCAS2 homolog) MOS4 BCAS2 SPF27 At3g18165 MRC8.16 Arabidopsis thaliana (Mouse-ear cress) TR37623_c1_g1_i3 Q6PBE2 SPF27_XENTR 1.00E-81 GO:0008380; GO:0006397; GO:0005681 RNA splicing; mRNA processing; spliceosomal complex IPR008409; Pre-mRNA-splicing factor SPF27 (Protein BCAS2 homolog) bcas2 TNeu112e09.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37625_c1_g1_i2 Q8C206 GP157_MOUSE 2.00E-13 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR022343; IPR017981; IPR000832; IPR017452; Probable G-protein coupled receptor 157 Gpr157 Mus musculus (Mouse) TR37626_c0_g3_i1 P62262 1433E_SHEEP 9.00E-131 GO:0042470 melanosome IPR000308; IPR023409; IPR023410; 14-3-3 protein epsilon (14-3-3E) (Protein kinase C inhibitor protein 1) (KCIP-1) YWHAE Ovis aries (Sheep) TR37627_c6_g1_i3 Q29RU2 OIT3_BOVIN 2.00E-14 GO:0005509; GO:0005635 calcium ion binding; nuclear envelope IPR000742; IPR000152; IPR018097; IPR009030; IPR001507; Oncoprotein-induced transcript 3 protein OIT3 Bos taurus (Bovine) TR37627_c6_g1_i7 Q8R4V5 OIT3_MOUSE 7.00E-09 GO:0005635 nuclear envelope IPR000742; IPR001507; Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein) Oit3 Lzp Mus musculus (Mouse) TR37629_c0_g1_i1 Q8CE96 TRM6_MOUSE 3.00E-106 GO:0005634; GO:0006446; GO:0008033; GO:0003743 nucleus; regulation of translational initiation; tRNA processing; translation initiation factor activity IPR007316; IPR017423; tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6) Trmt6 Kiaa1153 Trm6 Mus musculus (Mouse) TR37629_c0_g1_i2 Q8CE96 TRM6_MOUSE 2.00E-106 GO:0005634; GO:0006446; GO:0008033; GO:0003743 nucleus; regulation of translational initiation; tRNA processing; translation initiation factor activity IPR007316; IPR017423; tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6) Trmt6 Kiaa1153 Trm6 Mus musculus (Mouse) TR37629_c0_g1_i5 P0CS06 TRM6_CRYNJ 1.00E-19 GO:0005634; GO:0008033; GO:0003743 nucleus; tRNA processing; translation initiation factor activity IPR007316; tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6) TRM6 CNC01870 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR37632_c0_g2_i1 B3N6A5 EFGM_DROER 0 GO:0005525; GO:0003924; GO:0070125; GO:0005739; GO:0003746 GTP binding; GTPase activity; mitochondrial translational elongation; mitochondrion; translation elongation factor activity IPR000795; IPR009022; IPR000640; IPR027417; IPR020568; IPR014721; IPR005225; IPR009000; IPR004540; IPR005517; IPR004161; Protein biosynthesis; polypeptide chain elongation. "Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1)" ico GG23544 Drosophila erecta (Fruit fly) TR37632_c0_g2_i2 Q6CBI0 RRF2M_YARLI 9.00E-94 GO:0005525; GO:0006184; GO:0003924; GO:0005739; GO:0006412 GTP binding; GTP catabolic process; GTPase activity; mitochondrion; translation IPR000795; IPR009022; IPR000640; IPR027417; IPR014721; IPR005225; IPR009000; IPR004161; "Ribosome-releasing factor 2, mitochondrial (RRF2mt) (Elongation factor G 2, mitochondrial) (EF-G2mt) (mEF-G 2)" MEF2 YALI0C18557g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR37634_c0_g1_i1 C3YEM5 EFTS_BRAFL 3.00E-66 GO:0005739; GO:0003746 mitochondrion; translation elongation factor activity IPR001816; IPR014039; IPR018101; IPR009060; IPR000449; "Elongation factor Ts, mitochondrial (EF-Ts) (EF-TsMt)" BRAFLDRAFT_84221 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR37634_c0_g2_i1 O60234 GMFG_HUMAN 4.00E-53 GO:0008047; GO:0005622; GO:0004860; GO:0006468 enzyme activator activity; intracellular; protein kinase inhibitor activity; protein phosphorylation IPR002108; IPR011171; Glia maturation factor gamma (GMF-gamma) GMFG Homo sapiens (Human) TR37637_c0_g1_i1 P10160 IF5A1_RABIT 1.00E-67 GO:0005789; GO:0051028; GO:0005643; GO:0008612; GO:0045727; GO:0045901; GO:0045905; GO:0015031; GO:0043022; GO:0003746; GO:0006452 endoplasmic reticulum membrane; mRNA transport; nuclear pore; peptidyl-lysine modification to hypusine; positive regulation of translation; positive regulation of translational elongation; positive regulation of translational termination; protein transport; ribosome binding; translation elongation factor activity; translational frameshifting IPR012340; IPR014722; IPR019769; IPR001884; IPR020189; IPR008991; Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (eIF-4D) EIF5A Oryctolagus cuniculus (Rabbit) TR37637_c0_g1_i2 Q02217 YE034_YEAST 1.00E-13 GO:0016021 integral to membrane Putative uncharacterized protein YEL034C-A YEL034C-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR37637_c0_g1_i3 P10160 IF5A1_RABIT 1.00E-67 GO:0005789; GO:0051028; GO:0005643; GO:0008612; GO:0045727; GO:0045901; GO:0045905; GO:0015031; GO:0043022; GO:0003746; GO:0006452 endoplasmic reticulum membrane; mRNA transport; nuclear pore; peptidyl-lysine modification to hypusine; positive regulation of translation; positive regulation of translational elongation; positive regulation of translational termination; protein transport; ribosome binding; translation elongation factor activity; translational frameshifting IPR012340; IPR014722; IPR019769; IPR001884; IPR020189; IPR008991; Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (eIF-4D) EIF5A Oryctolagus cuniculus (Rabbit) TR37638_c1_g1_i3 Q9D1P4 CHRD1_MOUSE 4.00E-95 GO:0061077; GO:2000299; GO:1900034; GO:0010824; GO:0006950; GO:0008270 Q60676 chaperone-mediated protein folding; negative regulation of Rho-dependent protein serine/threonine kinase activity; regulation of cellular response to heat; regulation of centrosome duplication; response to stress; zinc ion binding IPR007051; IPR007052; IPR008978; Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (Chp-1) (Protein morgana) Chordc1 Chp1 Morgana Mus musculus (Mouse) TR37640_c1_g1_i1 Q96M91 CCD11_HUMAN 2.00E-34 IPR026773; Coiled-coil domain-containing protein 11 CCDC11 Homo sapiens (Human) TR37641_c0_g1_i1 Q96DI7 SNR40_HUMAN 6.00E-13 GO:0005682; GO:0071013; GO:0005737; GO:0000398; GO:0005654; GO:0005732 Q6P2Q9 "U5 snRNP; catalytic step 2 spliceosome; cytoplasm; mRNA splicing, via spliceosome; nucleoplasm; small nucleolar ribonucleoprotein complex" IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; U5 small nuclear ribonucleoprotein 40 kDa protein (U5 snRNP 40 kDa protein) (U5-40K) (38 kDa-splicing factor) (Prp8-binding protein) (hPRP8BP) (U5 snRNP-specific 40 kDa protein) (WD repeat-containing protein 57) SNRNP40 PRP8BP SFP38 WDR57 Homo sapiens (Human) TR37641_c0_g1_i2 Q15291 RBBP5_HUMAN 0 GO:0071339; GO:0048188; GO:0051568; GO:0035064; GO:0006355; GO:0006974; GO:0043627; GO:0044212; GO:0006351 Q9UBL3; Q9HCK8; Q13619; Q03164; P61964 "MLL1 complex; Set1C/COMPASS complex; histone H3-K4 methylation; methylated histone residue binding; regulation of transcription, DNA-dependent; response to DNA damage stimulus; response to estrogen stimulus; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR015943; IPR001680; IPR017986; Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3) RBBP5 RBQ3 Homo sapiens (Human) TR37642_c1_g1_i3 Q96AE7 TTC17_HUMAN 3.00E-121 IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 17 (TPR repeat protein 17) TTC17 Homo sapiens (Human) TR37642_c1_g1_i5 Q96AE7 TTC17_HUMAN 5.00E-20 IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 17 (TPR repeat protein 17) TTC17 Homo sapiens (Human) TR37644_c0_g1_i1 Q8BU31 RAP2C_MOUSE 4.00E-77 GO:0005525; GO:0003924; GO:0032486; GO:0005829; GO:0030336; GO:0031954; GO:0055038; GO:0061097 GTP binding; GTPase activity; Rap protein signal transduction; cytosol; negative regulation of cell migration; positive regulation of protein autophosphorylation; recycling endosome membrane; regulation of protein tyrosine kinase activity IPR027417; IPR005225; IPR001806; IPR020849; Ras-related protein Rap-2c Rap2c Mus musculus (Mouse) TR37647_c2_g1_i12 B2RX88 CSPP1_MOUSE 7.00E-12 GO:0005813; GO:0005737; GO:0005874; GO:0032467; GO:0000922 centrosome; cytoplasm; microtubule; positive regulation of cytokinesis; spindle pole IPR026708; Centrosome and spindle pole associated protein 1 Cspp1 Cspp Mus musculus (Mouse) TR37647_c2_g1_i2 Q1MSJ5 CSPP1_HUMAN 4.00E-13 GO:0005813; GO:0005737; GO:0005874; GO:0032467; GO:0000922 centrosome; cytoplasm; microtubule; positive regulation of cytokinesis; spindle pole IPR026708; Centrosome and spindle pole-associated protein 1 CSPP1 CSPP Homo sapiens (Human) TR37648_c0_g1_i1 Q9D0D3 PAPD1_MOUSE 1.00E-27 GO:0005524; GO:0005794; GO:0003723; GO:0002134; GO:0071044; GO:0006378; GO:0000287; GO:0030145; GO:0005739; GO:0005634; GO:0005886; GO:0004652; GO:0006351 "ATP binding; Golgi apparatus; RNA binding; UTP binding; histone mRNA catabolic process; mRNA polyadenylation; magnesium ion binding; manganese ion binding; mitochondrion; nucleus; plasma membrane; polynucleotide adenylyltransferase activity; transcription, DNA-dependent" IPR002058; "Poly(A) RNA polymerase, mitochondrial (PAP) (EC 2.7.7.19) (PAP-associated domain-containing protein 1) (Polynucleotide adenylyltransferase)" Mtpap Papd1 Mus musculus (Mouse) TR37648_c0_g2_i2 Q9H6E5 STPAP_HUMAN 9.00E-12 GO:0005524; GO:0050265; GO:0003730; GO:0006379; GO:0006378; GO:0046872; GO:0016607; GO:0005730; GO:0004652; GO:0016180 ATP binding; RNA uridylyltransferase activity; mRNA 3'-UTR binding; mRNA cleavage; mRNA polyadenylation; metal ion binding; nuclear speck; nucleolus; polynucleotide adenylyltransferase activity; snRNA processing IPR012677; IPR002058; IPR000504; IPR015880; Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) TUT1 RBM21 Homo sapiens (Human) TR37649_c0_g1_i1 Q5BK18 NARFL_RAT 8.00E-175 GO:0051539; GO:0097361; GO:0016226; GO:0046872; GO:0032364; GO:0006355; GO:0001666 "4 iron, 4 sulfur cluster binding; CIA complex; iron-sulfur cluster assembly; metal ion binding; oxygen homeostasis; regulation of transcription, DNA-dependent; response to hypoxia" IPR009016; IPR004108; IPR003149; Cytosolic Fe-S cluster assembly factor NARFL (Iron-only hydrogenase-like protein 1) (IOP1) (Nuclear prelamin A recognition factor-like protein) Narfl Rattus norvegicus (Rat) TR37649_c0_g1_i2 P0CP11 NAR1_CRYNB 2.00E-76 GO:0051539; GO:0016226; GO:0051536; GO:0046872 "4 iron, 4 sulfur cluster binding; iron-sulfur cluster assembly; iron-sulfur cluster binding; metal ion binding" IPR009016; IPR004108; Cytosolic Fe-S cluster assembly factor NAR1 (Nuclear architecture-related protein 1) NAR1 CNBH3260 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) TR37651_c1_g2_i2 Q1JPJ8 THOP1_BOVIN 0 GO:0005737; GO:0046872; GO:0004222; GO:0006508 cytoplasm; metal ion binding; metalloendopeptidase activity; proteolysis IPR024079; IPR024077; IPR024080; IPR001567; Thimet oligopeptidase (EC 3.4.24.15) THOP1 Bos taurus (Bovine) TR37653_c0_g2_i1 Q9H1D9 RPC6_HUMAN 4.00E-85 GO:0003677; GO:0005666; GO:0003899; GO:0005829; GO:0051607; GO:0045087; GO:0045089; GO:0032728; GO:0006359; GO:0006386; GO:0006385 Q12796; Q13523 DNA binding; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase activity; cytosol; defense response to virus; innate immune response; positive regulation of innate immune response; positive regulation of interferon-beta production; regulation of transcription from RNA polymerase III promoter; termination of RNA polymerase III transcription; transcription elongation from RNA polymerase III promoter IPR007832; IPR016049; DNA-directed RNA polymerase III subunit RPC6 (RNA polymerase III subunit C6) (DNA-directed RNA polymerase III subunit F) (RNA polymerase III 39 kDa subunit) (RPC39) POLR3F Homo sapiens (Human) TR37653_c0_g2_i6 Q86JM3 RPC6_DICDI 1.00E-25 GO:0003677; GO:0005666; GO:0003899; GO:0006383 DNA binding; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase activity; transcription from RNA polymerase III promoter IPR007832; IPR016049; DNA-directed RNA polymerase III subunit rpc6 (RNA polymerase III subunit C6) (DNA-directed RNA polymerase III subunit F) polr3f rpc34 rpc6 DDB_G0272022 Dictyostelium discoideum (Slime mold) TR37654_c0_g1_i1 Q99797 MIPEP_HUMAN 1.00E-144 GO:0046872; GO:0004222; GO:0005759; GO:0005739; GO:0006627; GO:0006508 metal ion binding; metalloendopeptidase activity; mitochondrial matrix; mitochondrion; protein processing involved in protein targeting to mitochondrion; proteolysis IPR024079; IPR024077; IPR024080; IPR001567; Mitochondrial intermediate peptidase (MIP) (EC 3.4.24.59) MIPEP MIP Homo sapiens (Human) TR37654_c0_g1_i2 A4RF25 PMIP_MAGO7 5.00E-47 GO:0046872; GO:0004222; GO:0005759; GO:0006508 metal ion binding; metalloendopeptidase activity; mitochondrial matrix; proteolysis IPR024079; IPR024077; IPR001567; Mitochondrial intermediate peptidase (MIP) (EC 3.4.24.59) (Octapeptidyl aminopeptidase) OCT1 MGG_00487 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) TR37656_c1_g1_i1 Q9DA37 SAMD8_MOUSE 1.00E-54 GO:0046513; GO:0030176; GO:2000303; GO:0006686; GO:0016740 ceramide biosynthetic process; integral to endoplasmic reticulum membrane; regulation of ceramide biosynthetic process; sphingomyelin biosynthetic process; transferase activity IPR001660; IPR013761; IPR021129; IPR025749; Sphingomyelin synthase-related protein 1 (SMSr) (EC 2.7.8.-) (Ceramide phosphoethanolamine synthase) (CPE synthase) (Sterile alpha motif domain-containing protein 8) (SAM domain-containing protein 8) Samd8 Mus musculus (Mouse) TR37657_c3_g3_i2 A0PK84 ZDH22_MOUSE 5.00E-22 GO:0016021; GO:0072659; GO:0018345; GO:0016746; GO:0008270 "integral to membrane; protein localization to plasma membrane; protein palmitoylation; transferase activity, transferring acyl groups; zinc ion binding" IPR000731; IPR001594; Palmitoyltransferase ZDHHC22 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 22) (DHHC-22) (zDHHC22) Zdhhc22 Gm262 Mus musculus (Mouse) TR37658_c0_g1_i8 Q98925 IRF2_CHICK 7.00E-34 GO:0005925; GO:0005634; GO:0000975; GO:0003700; GO:0006351 "focal adhesion; nucleus; regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017431; IPR019817; IPR001346; IPR011991; Interferon regulatory factor 2 (IRF-2) IRF2 Gallus gallus (Chicken) TR37659_c0_g1_i1 Q6R748 STXB1_CHICK 0 GO:0005737; GO:0016020; GO:0015031; GO:0006904 cytoplasm; membrane; protein transport; vesicle docking involved in exocytosis IPR027482; IPR001619; Syntaxin-binding protein 1 (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) STXBP1 UNC18A Gallus gallus (Chicken) TR37659_c0_g1_i2 Q5VNU3 SEC1B_ORYSJ 2.00E-73 GO:0015031; GO:0006904 protein transport; vesicle docking involved in exocytosis IPR027482; IPR001619; Probable protein transport Sec1b Os06g0135900 LOC_Os06g04450 P0001H02.27 P0548D03.12 Oryza sativa subsp. japonica (Rice) TR3766_c0_g1_i1 P24032 MLRN_CHICK 3.00E-53 GO:0005509; GO:0016459 calcium ion binding; myosin complex IPR011992; IPR018247; IPR002048; "Myosin regulatory light chain 2, smooth muscle minor isoform (MLC-2) (DTNB) (G1) (Isoform L20-B1)" Gallus gallus (Chicken) TR37660_c0_g1_i2 O70277 TRIM3_RAT 2.00E-08 GO:0005737; GO:0005769; GO:0015031; GO:0008270 cytoplasm; early endosome; protein transport; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) TR37662_c0_g1_i1 Q8WUM4 PDC6I_HUMAN 3.00E-167 GO:0006915; GO:0007049; GO:0051301; GO:0005829; GO:0042470; GO:0005815; GO:0019048; GO:0015031; GO:0016032 Q9Y5K6; Q53EZ4; P06241; P03347; P69730; P08631; P09022; O75340 apoptotic process; cell cycle; cell division; cytosol; melanosome; microtubule organizing center; modulation by virus of host morphology or physiology; protein transport; viral process IPR025304; IPR004328; Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) PDCD6IP AIP1 ALIX KIAA1375 Homo sapiens (Human) TR37662_c0_g1_i2 Q9W6C5 PDC6I_XENLA 1.00E-174 GO:0015031 protein transport IPR025304; IPR004328; Programmed cell death 6-interacting protein (Signal transduction protein Xp95) pdcd6ip Xenopus laevis (African clawed frog) TR37662_c0_g1_i3 Q4X0Z5 BRO1_ASPFU 3.00E-33 GO:0005768; GO:0015031 endosome; protein transport IPR025304; IPR004328; Vacuolar protein-sorting protein bro1 (BRO domain-containing protein 1) bro1 AFUA_2G11760 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) TR37662_c0_g3_i1 Q6BRL3 BRO1_DEBHA 1.00E-14 GO:0005768; GO:0015031 endosome; protein transport IPR025304; IPR004328; Vacuolar protein-sorting protein BRO1 (BRO domain-containing protein 1) BRO1 DEHA2D15510g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR37663_c0_g1_i2 Q75WF2 DNA2_ACAPL 2.00E-41 GO:0006259; GO:0006915; GO:0004531; GO:0005576; GO:0090305 DNA metabolic process; apoptotic process; deoxyribonuclease II activity; extracellular region; nucleic acid phosphodiester bond hydrolysis IPR004947; Plancitoxin-1 (EC 3.1.22.1) (Plancitoxin I) (Plan-I) [Cleaved into: Plancitoxin-1 subunit alpha; Plancitoxin-1 subunit beta] Acanthaster planci (Crown-of-thorns starfish) TR37663_c0_g1_i5 O00115 DNS2A_HUMAN 1.00E-63 GO:0003677; GO:0006308; GO:0006259; GO:0006915; GO:0004531; GO:0030218; GO:0005764 Q9Y265; Q9Y230 DNA binding; DNA catabolic process; DNA metabolic process; apoptotic process; deoxyribonuclease II activity; erythrocyte differentiation; lysosome IPR004947; Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) (R31240_2) DNASE2 DNASE2A DNL2 Homo sapiens (Human) TR37663_c0_g1_i8 Q75WF2 DNA2_ACAPL 6.00E-68 GO:0006259; GO:0006915; GO:0004531; GO:0005576; GO:0090305 DNA metabolic process; apoptotic process; deoxyribonuclease II activity; extracellular region; nucleic acid phosphodiester bond hydrolysis IPR004947; Plancitoxin-1 (EC 3.1.22.1) (Plancitoxin I) (Plan-I) [Cleaved into: Plancitoxin-1 subunit alpha; Plancitoxin-1 subunit beta] Acanthaster planci (Crown-of-thorns starfish) TR37664_c0_g2_i1 Q9NUW8 TYDP1_HUMAN 2.00E-104 GO:0017005; GO:0008219; GO:0005737; GO:0006302; GO:0003690; GO:0004527; GO:0090305; GO:0005634; GO:0000012; GO:0003697 3'-tyrosyl-DNA phosphodiesterase activity; cell death; cytoplasm; double-strand break repair; double-stranded DNA binding; exonuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus; single strand break repair; single-stranded DNA binding IPR027415; IPR010347; Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) TDP1 Homo sapiens (Human) TR37665_c1_g1_i1 B0XK69 SDHF2_CULQU 4.00E-40 GO:0006121; GO:0005739; GO:0018293 "mitochondrial electron transport, succinate to ubiquinone; mitochondrion; protein-FAD linkage" IPR005631; "Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (Succinate dehydrogenase subunit 5, mitochondrial)" CPIJ019830 Culex quinquefasciatus (Southern house mosquito) (Culex pungens) TR37665_c1_g1_i3 Q178L7 SDHF2_AEDAE 9.00E-40 GO:0006121; GO:0005739; GO:0018293 "mitochondrial electron transport, succinate to ubiquinone; mitochondrion; protein-FAD linkage" IPR005631; "Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (Succinate dehydrogenase subunit 5, mitochondrial)" AAEL005866 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR37665_c1_g1_i5 B0XK69 SDHF2_CULQU 1.00E-40 GO:0006121; GO:0005739; GO:0018293 "mitochondrial electron transport, succinate to ubiquinone; mitochondrion; protein-FAD linkage" IPR005631; "Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (Succinate dehydrogenase subunit 5, mitochondrial)" CPIJ019830 Culex quinquefasciatus (Southern house mosquito) (Culex pungens) TR37665_c1_g1_i6 A5DT64 SDHF2_LODEL 3.00E-19 GO:0006121; GO:0005759; GO:0018293 "mitochondrial electron transport, succinate to ubiquinone; mitochondrial matrix; protein-FAD linkage" IPR005631; "Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (Early meiotic induction protein 5) (Succinate dehydrogenase subunit 5, mitochondrial)" EMI5 SDH5 LELG_00550 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus) TR37667_c0_g1_i3 Q8BZ47 ZN609_MOUSE 2.00E-58 GO:0046872 metal ion binding IPR007087; IPR015880; Zinc finger protein 609 Znf609 Kiaa0295 Zfp609 Mus musculus (Mouse) TR37670_c0_g1_i1 Q25117 ATPB_HEMPU 0 GO:0005524; GO:0015991; GO:0015986; GO:0005743; GO:0046933; GO:0045261 "ATP binding; ATP hydrolysis coupled proton transport; ATP synthesis coupled proton transport; mitochondrial inner membrane; proton-transporting ATP synthase activity, rotational mechanism; proton-transporting ATP synthase complex, catalytic core F(1)" IPR003593; IPR020003; IPR005722; IPR000793; IPR000194; IPR004100; IPR024034; IPR027417; "ATP synthase subunit beta, mitochondrial (EC 3.6.3.14)" Hemicentrotus pulcherrimus (Sea urchin) (Strongylocentrotus pulcherrimus) TR37672_c0_g2_i1 P42519 STAR_DROME 4.00E-10 GO:0005794; GO:0000139; GO:0048149; GO:0046845; GO:0046667; GO:0035225; GO:0005789; GO:0038004; GO:0007173; GO:0061331; GO:0007476; GO:0016021; GO:0007498; GO:0016318; GO:0048477; GO:0097038; GO:0007422; GO:0042461; GO:0005886; GO:0000042; GO:0048865; GO:0007421; GO:0007601 "Golgi apparatus; Golgi membrane; behavioral response to ethanol; branched duct epithelial cell fate determination, open tracheal system; compound eye retinal cell programmed cell death; determination of genital disc primordium; endoplasmic reticulum membrane; epidermal growth factor receptor ligand maturation; epidermal growth factor receptor signaling pathway; epithelial cell proliferation involved in Malpighian tubule morphogenesis; imaginal disc-derived wing morphogenesis; integral to membrane; mesoderm development; ommatidial rotation; oogenesis; perinuclear endoplasmic reticulum; peripheral nervous system development; photoreceptor cell development; plasma membrane; protein targeting to Golgi; stem cell fate commitment; stomatogastric nervous system development; visual perception" IPR006342; Protein Star S CG4385 Drosophila melanogaster (Fruit fly) TR37673_c2_g1_i1 Q5U4F6 WDR34_MOUSE 6.00E-127 GO:0005737 cytoplasm IPR015943; IPR001680; IPR017986; WD repeat-containing protein 34 Wdr34 Mus musculus (Mouse) TR37673_c5_g1_i1 Q6NXH8 MET25_MOUSE 1.00E-10 GO:0008168 methyltransferase activity IPR025714; Methyltransferase-like protein 25 (EC 2.1.1.-) Mettl25 Mus musculus (Mouse) TR37673_c5_g4_i1 Q96FB5 RRNAD_HUMAN 5.00E-27 GO:0016021; GO:0000179; GO:0031167 "integral to membrane; rRNA (adenine-N6,N6-)-dimethyltransferase activity; rRNA methylation" IPR025714; IPR020596; Protein RRNAD1 (Ribosomal RNA adenine dimethylase domain-containing protein 1) RRNAD1 C1orf66 CGI-41 Homo sapiens (Human) TR37673_c5_g4_i2 Q8N6Q8 MET25_HUMAN 6.00E-18 GO:0008168 methyltransferase activity IPR025714; Methyltransferase-like protein 25 (EC 2.1.1.-) METTL25 C12orf26 Homo sapiens (Human) TR37675_c2_g1_i1 A5PK39 TPP2_BOVIN 0 GO:0004177; GO:0005737; GO:0005634; GO:0006508; GO:0004252 aminopeptidase activity; cytoplasm; nucleus; proteolysis; serine-type endopeptidase activity IPR000209; IPR022398; IPR023828; IPR015500; IPR022229; Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) TPP2 Bos taurus (Bovine) TR37676_c0_g1_i2 Q09614 PTC1_CAEEL 8.00E-08 GO:0051301; GO:0008158; GO:0005887; GO:0007067; GO:0018996 "cell division; hedgehog receptor activity; integral to plasma membrane; mitosis; molting cycle, collagen and cuticulin-based cuticle" IPR003392; IPR000731; Protein patched homolog 1 ptc-1 ZK675.1 Caenorhabditis elegans TR37676_c0_g1_i3 Q0EEE2 PTHD3_MOUSE 4.00E-63 GO:0008158; GO:0016021 hedgehog receptor activity; integral to membrane IPR003392; IPR000731; Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) TR37676_c0_g1_i4 Q0EEE2 PTHD3_MOUSE 5.00E-51 GO:0008158; GO:0016021 hedgehog receptor activity; integral to membrane IPR003392; IPR000731; Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) TR37676_c0_g1_i5 P56941 NPC1_PIG 3.00E-14 GO:0008206; GO:0015485; GO:0042632; GO:0008203; GO:0030301; GO:0005783; GO:0005576; GO:0008158; GO:0005887; GO:0031902; GO:0005765; GO:0007041; GO:0005764; GO:0005635; GO:0048471; GO:0006486 bile acid metabolic process; cholesterol binding; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; endoplasmic reticulum; extracellular region; hedgehog receptor activity; integral to plasma membrane; late endosome membrane; lysosomal membrane; lysosomal transport; lysosome; nuclear envelope; perinuclear region of cytoplasm; protein glycosylation IPR004765; IPR003392; IPR000731; Niemann-Pick C1 protein NPC1 Sus scrofa (Pig) TR37677_c0_g1_i1 Q5ZHV8 RMI1_CHICK 2.00E-54 GO:0006260; GO:0005634 DNA replication; nucleus IPR013894; RecQ-mediated genome instability protein 1 RMI1 RCJMB04_32l8 Gallus gallus (Chicken) TR37678_c0_g1_i1 P62335 PRS10_SPETR 0 GO:0005524; GO:0005737; GO:0017111; GO:0005634; GO:0005886; GO:0022624; GO:0030163 ATP binding; cytoplasm; nucleoside-triphosphatase activity; nucleus; plasma membrane; proteasome accessory complex; protein catabolic process IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Conserved ATPase domain protein 44) (CADp44) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42) PSMC6 SUG2 Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) (Ictidomys tridecemlineatus) TR37680_c3_g1_i1 Q9BTV4 TMM43_HUMAN 8.00E-101 GO:0005794; GO:0005783; GO:0016021; GO:0005637 Golgi apparatus; endoplasmic reticulum; integral to membrane; nuclear inner membrane IPR012430; Transmembrane protein 43 (Protein LUMA) TMEM43 UNQ2564/PRO6244 Homo sapiens (Human) TR37680_c3_g1_i2 Q9BTV4 TMM43_HUMAN 4.00E-65 GO:0005794; GO:0005783; GO:0016021; GO:0005637 Golgi apparatus; endoplasmic reticulum; integral to membrane; nuclear inner membrane IPR012430; Transmembrane protein 43 (Protein LUMA) TMEM43 UNQ2564/PRO6244 Homo sapiens (Human) TR37681_c0_g2_i1 Q14246 EMR1_HUMAN 2.00E-06 GO:0004930; GO:0005509; GO:0007155; GO:0009897; GO:0005887; GO:0007218 G-protein coupled receptor activity; calcium ion binding; cell adhesion; external side of plasma membrane; integral to plasma membrane; neuropeptide signaling pathway IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR017981; IPR001740; IPR000832; IPR017983; IPR000203; IPR009030; EGF-like module-containing mucin-like hormone receptor-like 1 (EGF-like module receptor 1) (EMR1 hormone receptor) EMR1 TM7LN3 Homo sapiens (Human) TR37682_c2_g1_i1 Q4V860 TFCP2_XENLA 3.00E-33 GO:0003677; GO:0005634; GO:0006355; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007604; IPR013761; Transcription factor CP2 tfcp2 Xenopus laevis (African clawed frog) TR37682_c2_g3_i1 Q4V860 TFCP2_XENLA 2.00E-33 GO:0003677; GO:0005634; GO:0006355; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007604; IPR013761; Transcription factor CP2 tfcp2 Xenopus laevis (African clawed frog) TR37683_c3_g2_i1 P04323 POL3_DROME 3.00E-14 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR37690_c2_g1_i1 A5PLL7 TM189_HUMAN 3.00E-27 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR019547; Transmembrane protein 189 TMEM189 KUA Homo sapiens (Human) TR37690_c4_g1_i1 Q9CQU1 MFAP1_MOUSE 6.00E-76 GO:0005578 proteinaceous extracellular matrix IPR009730; Microfibrillar-associated protein 1 Mfap1 Mus musculus (Mouse) TR37690_c4_g1_i3 P55080 MFAP1_CHICK 6.00E-76 GO:0005578 proteinaceous extracellular matrix IPR009730; Microfibrillar-associated protein 1 (Associated microfibril protein) (AMF) MFAP1 Gallus gallus (Chicken) TR37690_c4_g1_i4 P55080 MFAP1_CHICK 1.00E-75 GO:0005578 proteinaceous extracellular matrix IPR009730; Microfibrillar-associated protein 1 (Associated microfibril protein) (AMF) MFAP1 Gallus gallus (Chicken) TR37692_c1_g1_i1 Q75J93 CPAS1_DICDI 1.00E-34 GO:0030127; GO:0006888; GO:0005525; GO:0003924; GO:0006886; GO:0007264; GO:0008270 COPII vesicle coat; ER to Golgi vesicle-mediated transport; GTP binding; GTPase activity; intracellular protein transport; small GTPase mediated signal transduction; zinc ion binding IPR027417; IPR005225; IPR001806; IPR020849; IPR002035; IPR006895; Circularly permutated Ras protein 1 (DdiCPRas1) cpras1 DDB_G0277381 Dictyostelium discoideum (Slime mold) TR37692_c1_g1_i2 Q5EFX7 RASK_KRYMA 7.00E-91 GO:0005525; GO:0003924; GO:0005886; GO:0007264 GTP binding; GTPase activity; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; GTPase KRas (Ki-Ras) (K-ras) kras Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus) TR37692_c1_g1_i3 Q75J93 CPAS1_DICDI 2.00E-34 GO:0030127; GO:0006888; GO:0005525; GO:0003924; GO:0006886; GO:0007264; GO:0008270 COPII vesicle coat; ER to Golgi vesicle-mediated transport; GTP binding; GTPase activity; intracellular protein transport; small GTPase mediated signal transduction; zinc ion binding IPR027417; IPR005225; IPR001806; IPR020849; IPR002035; IPR006895; Circularly permutated Ras protein 1 (DdiCPRas1) cpras1 DDB_G0277381 Dictyostelium discoideum (Slime mold) TR37692_c1_g1_i7 Q5EFX7 RASK_KRYMA 3.00E-92 GO:0005525; GO:0003924; GO:0005886; GO:0007264 GTP binding; GTPase activity; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; GTPase KRas (Ki-Ras) (K-ras) kras Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus) TR37693_c0_g1_i2 Q86TV6 TTC7B_HUMAN 3.00E-142 IPR013026; IPR011990; IPR013105; IPR019734; IPR026900; Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1) TTC7B TTC7L1 Homo sapiens (Human) TR37697_c0_g1_i2 P78314 3BP2_HUMAN 5.00E-18 GO:0005070; GO:0005543; GO:0007165 Q9UJU6; Q96B97; Q9H2K2; P15498; P52735 SH3/SH2 adaptor activity; phospholipid binding; signal transduction IPR011993; IPR001849; IPR000980; SH3 domain-binding protein 2 (3BP-2) SH3BP2 3BP2 RES4-23 Homo sapiens (Human) TR37697_c1_g3_i1 O00567 NOP56_HUMAN 1.00E-49 GO:0031428; GO:0008219; GO:0005737; GO:0070761; GO:0006364; GO:0030515 box C/D snoRNP complex; cell death; cytoplasm; pre-snoRNP complex; rRNA processing; snoRNA binding IPR012974; IPR002687; IPR012976; Nucleolar protein 56 (Nucleolar protein 5A) NOP56 NOL5A Homo sapiens (Human) TR37697_c1_g4_i2 O00567 NOP56_HUMAN 0 GO:0031428; GO:0008219; GO:0005737; GO:0070761; GO:0006364; GO:0030515 box C/D snoRNP complex; cell death; cytoplasm; pre-snoRNP complex; rRNA processing; snoRNA binding IPR012974; IPR002687; IPR012976; Nucleolar protein 56 (Nucleolar protein 5A) NOP56 NOL5A Homo sapiens (Human) TR37698_c0_g1_i1 Q6ZWL3 CP4V2_HUMAN 2.00E-43 GO:0005789; GO:0010430; GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705; GO:0050896; GO:0007601 "endoplasmic reticulum membrane; fatty acid omega-oxidation; heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; response to stimulus; visual perception" IPR001128; IPR017972; IPR002401; Cytochrome P450 4V2 (EC 1.14.13.-) CYP4V2 Homo sapiens (Human) TR37698_c0_g1_i2 Q9WVK8 CP46A_MOUSE 3.00E-114 GO:0033781; GO:0006707; GO:0005789; GO:0020037; GO:0016021; GO:0005506; GO:0006805 cholesterol 24-hydroxylase activity; cholesterol catabolic process; endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding; xenobiotic metabolic process IPR001128; IPR017972; IPR002401; Cholesterol 24-hydroxylase (CH24H) (EC 1.14.13.98) (Cytochrome P450 46A1) Cyp46a1 Cyp46 Mus musculus (Mouse) TR37700_c1_g3_i1 Q07508 LUC7_YEAST 5.00E-28 GO:0005685; GO:0071004; GO:0005829; GO:0003729; GO:0006376 U1 snRNP; U2-type prespliceosome; cytosol; mRNA binding; mRNA splice site selection IPR004882; Protein LUC7 LUC7 EPE1 EXM2 YDL087C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR37700_c1_g3_i2 Q9Y383 LC7L2_HUMAN 4.00E-102 GO:0005685; GO:0003729; GO:0006376; GO:0016607 Q9GZQ8; Q96SB4; P78362 U1 snRNP; mRNA binding; mRNA splice site selection; nuclear speck IPR004882; Putative RNA-binding protein Luc7-like 2 LUC7L2 CGI-59 CGI-74 Homo sapiens (Human) TR37702_c0_g1_i1 Q503I9 GLD2_DANRE 2.00E-36 GO:0005524; GO:0043631; GO:0005737; GO:0006397; GO:0046872; GO:0004652 ATP binding; RNA polyadenylation; cytoplasm; mRNA processing; metal ion binding; polynucleotide adenylyltransferase activity IPR002934; IPR002058; Poly(A) RNA polymerase GLD2 (EC 2.7.7.19) (PAP-associated domain-containing protein 4) papd4 zgc:110560 Danio rerio (Zebrafish) (Brachydanio rerio) TR37702_c0_g1_i2 B2RX14 TUT4_MOUSE 0 GO:0031123; GO:0050265; GO:0001816; GO:0005737; GO:0070102; GO:0010587; GO:0032088; GO:0003676; GO:0005634; GO:0032755; GO:0031054; GO:0031664; GO:0019827; GO:0008270 RNA 3'-end processing; RNA uridylyltransferase activity; cytokine production; cytoplasm; interleukin-6-mediated signaling pathway; miRNA catabolic process; negative regulation of NF-kappaB transcription factor activity; nucleic acid binding; nucleus; positive regulation of interleukin-6 production; pre-miRNA processing; regulation of lipopolysaccharide-mediated signaling pathway; stem cell maintenance; zinc ion binding IPR002934; IPR002058; IPR001878; Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) Zcchc11 Kiaa0191 Tut4 Mus musculus (Mouse) TR37702_c0_g1_i3 Q641A1 GLD2A_XENLA 2.00E-36 GO:0005524; GO:0043631; GO:0030154; GO:0005737; GO:0006397; GO:0046872; GO:0007275; GO:0048477; GO:0004652 ATP binding; RNA polyadenylation; cell differentiation; cytoplasm; mRNA processing; metal ion binding; multicellular organismal development; oogenesis; polynucleotide adenylyltransferase activity IPR002934; IPR002058; Poly(A) RNA polymerase GLD2-A (EC 2.7.7.19) (PAP-associated domain-containing protein 4-A) papd4-a gld2-a Xenopus laevis (African clawed frog) TR37702_c0_g1_i4 B2RX14 TUT4_MOUSE 6.00E-20 GO:0031123; GO:0050265; GO:0001816; GO:0005737; GO:0070102; GO:0010587; GO:0032088; GO:0003676; GO:0005634; GO:0032755; GO:0031054; GO:0031664; GO:0019827; GO:0008270 RNA 3'-end processing; RNA uridylyltransferase activity; cytokine production; cytoplasm; interleukin-6-mediated signaling pathway; miRNA catabolic process; negative regulation of NF-kappaB transcription factor activity; nucleic acid binding; nucleus; positive regulation of interleukin-6 production; pre-miRNA processing; regulation of lipopolysaccharide-mediated signaling pathway; stem cell maintenance; zinc ion binding IPR002934; IPR002058; IPR001878; Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) Zcchc11 Kiaa0191 Tut4 Mus musculus (Mouse) TR37704_c2_g2_i1 Q9H2F5 EPC1_HUMAN 5.00E-147 GO:0032777; GO:0043968; GO:0043967; GO:0045814; GO:0000122; GO:0031965; GO:0045944; GO:0040008; GO:0006351 "Piccolo NuA4 histone acetyltransferase complex; histone H2A acetylation; histone H4 acetylation; negative regulation of gene expression, epigenetic; negative regulation of transcription from RNA polymerase II promoter; nuclear membrane; positive regulation of transcription from RNA polymerase II promoter; regulation of growth; transcription, DNA-dependent" IPR024943; IPR019542; IPR009607; Enhancer of polycomb homolog 1 EPC1 Homo sapiens (Human) TR37704_c2_g2_i3 O88350 RBBP9_RAT 2.00E-78 GO:0005737; GO:0016787; GO:0005634; GO:0042127 P33568 cytoplasm; hydrolase activity; nucleus; regulation of cell proliferation IPR010662; Putative hydrolase RBBP9 (EC 3.-.-.-) (B5T-overexpressed gene protein) (Protein BOG) (Retinoblastoma-binding protein 9) (RBBP-9) Rbbp9 Bog Rattus norvegicus (Rat) TR37704_c2_g2_i5 O88350 RBBP9_RAT 9.00E-81 GO:0005737; GO:0016787; GO:0005634; GO:0042127 P33568 cytoplasm; hydrolase activity; nucleus; regulation of cell proliferation IPR010662; Putative hydrolase RBBP9 (EC 3.-.-.-) (B5T-overexpressed gene protein) (Protein BOG) (Retinoblastoma-binding protein 9) (RBBP-9) Rbbp9 Bog Rattus norvegicus (Rat) TR37704_c2_g2_i6 Q9H2F5 EPC1_HUMAN 8.00E-18 GO:0032777; GO:0043968; GO:0043967; GO:0045814; GO:0000122; GO:0031965; GO:0045944; GO:0040008; GO:0006351 "Piccolo NuA4 histone acetyltransferase complex; histone H2A acetylation; histone H4 acetylation; negative regulation of gene expression, epigenetic; negative regulation of transcription from RNA polymerase II promoter; nuclear membrane; positive regulation of transcription from RNA polymerase II promoter; regulation of growth; transcription, DNA-dependent" IPR024943; IPR019542; IPR009607; Enhancer of polycomb homolog 1 EPC1 Homo sapiens (Human) TR37704_c2_g3_i3 Q96EB6 SIR1_HUMAN 8.00E-163 GO:0006260; GO:0000731; GO:0070403; GO:0046969; GO:0016605; GO:0001525; GO:0007569; GO:0001678; GO:0070301; GO:0071456; GO:0071479; GO:0009267; GO:0071356; GO:0035356; GO:0042632; GO:0000183; GO:0005677; GO:0005737; GO:0006343; GO:0055089; GO:0042771; GO:0006344; GO:0046872; GO:0006346; GO:0019048; GO:0007517; GO:0043518; GO:0043124; GO:0032088; GO:0032007; GO:0060766; GO:0043066; GO:2000480; GO:0030308; GO:2000655; GO:2000773; GO:0045599; GO:0051097; GO:1902166; GO:1902176; GO:2000757; GO:0031393; GO:0051898; GO:0000122; GO:0030512; GO:0005719; GO:0005720; GO:0005637; GO:0005730; GO:0001542; GO:0018394; GO:0034983; GO:0045739; GO:0045348; GO:0002821; GO:2000481; GO:0008284; GO:2000774; GO:0010875; GO:0031937; GO:0043280; GO:0046628; GO:0016239; GO:2000111; GO:0045944; GO:0043161; GO:0031648; GO:0016567; GO:0000720; GO:0033553; GO:0006364; GO:0070857; GO:0032071; GO:0010906; GO:0007346; GO:0035358; GO:0033158; GO:0034391; GO:0032868; GO:0000012; GO:0007283; GO:0003714; GO:0006351; GO:0006642; GO:0050872 Q13085; P31749; P27695; P33076; Q9NS37; P68400; P67870; P26358; Q01094; Q09472; Q14192; Q12778; Q9R1E0; O43524; P98177; P51610; Q14469; Q9UBP5; Q9Y4H2; Q92831; Q8N163; Q03112; P42345; P01106; P04198; O60934; Q60974; Q02577; Q9HAN9; Q15466; Q60644; Q9Z0Y9; P27986; P37238; P37238-1; P10276; Q04206; Q86WX3; Q8N122; O43159; Q13573; P36956-3; O54864; P04608; Q04724; P04637; O15350; P49815; Q14191; P23025; P12956 "DNA replication; DNA synthesis involved in DNA repair; NAD+ binding; NAD-dependent histone deacetylase activity (H3-K9 specific); PML body; angiogenesis; cell aging; cellular glucose homeostasis; cellular response to hydrogen peroxide; cellular response to hypoxia; cellular response to ionizing radiation; cellular response to starvation; cellular response to tumor necrosis factor; cellular triglyceride homeostasis; cholesterol homeostasis; chromatin silencing at rDNA; chromatin silencing complex; cytoplasm; establishment of chromatin silencing; fatty acid homeostasis; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; maintenance of chromatin silencing; metal ion binding; methylation-dependent chromatin silencing; modulation by virus of host morphology or physiology; muscle organ development; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of TOR signaling cascade; negative regulation of androgen receptor signaling pathway; negative regulation of apoptotic process; negative regulation of cAMP-dependent protein kinase activity; negative regulation of cell growth; negative regulation of cellular response to testosterone stimulus; negative regulation of cellular senescence; negative regulation of fat cell differentiation; negative regulation of helicase activity; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress; negative regulation of peptidyl-lysine acetylation; negative regulation of prostaglandin biosynthetic process; negative regulation of protein kinase B signaling cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; nuclear euchromatin; nuclear heterochromatin; nuclear inner membrane; nucleolus; ovulation from ovarian follicle; peptidyl-lysine acetylation; peptidyl-lysine deacetylation; positive regulation of DNA repair; positive regulation of MHC class II biosynthetic process; positive regulation of adaptive immune response; positive regulation of cAMP-dependent protein kinase activity; positive regulation of cell proliferation; positive regulation of cellular senescence; positive regulation of cholesterol efflux; positive regulation of chromatin silencing; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of insulin receptor signaling pathway; positive regulation of macroautophagy; positive regulation of macrophage apoptotic process; positive regulation of transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; protein destabilization; protein ubiquitination; pyrimidine dimer repair by nucleotide-excision repair; rDNA heterochromatin; rRNA processing; regulation of bile acid biosynthetic process; regulation of endodeoxyribonuclease activity; regulation of glucose metabolic process; regulation of mitotic cell cycle; regulation of peroxisome proliferator activated receptor signaling pathway; regulation of protein import into nucleus, translocation; regulation of smooth muscle cell apoptotic process; response to insulin stimulus; single strand break repair; spermatogenesis; transcription corepressor activity; transcription, DNA-dependent; triglyceride mobilization; white fat cell differentiation" IPR003000; IPR026591; IPR026590; NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 3.5.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] SIRT1 SIR2L1 Homo sapiens (Human) TR37705_c0_g1_i1 Q06190 P2R3A_HUMAN 3.00E-130 GO:0090244; GO:0005509; GO:0001754; GO:0090090; GO:0090263; GO:0045732; GO:0006470; GO:0000159; GO:0008601; GO:0090249; GO:0007525; GO:0061053 Q969G9 Wnt receptor signaling pathway involved in somitogenesis; calcium ion binding; eye photoreceptor cell differentiation; negative regulation of canonical Wnt receptor signaling pathway; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of protein catabolic process; protein dephosphorylation; protein phosphatase type 2A complex; protein phosphatase type 2A regulator activity; regulation of cell motility involved in somitogenic axis elongation; somatic muscle development; somite development IPR011992; IPR018247; IPR002048; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B''-PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B) PPP2R3A PPP2R3 Homo sapiens (Human) TR37705_c0_g1_i3 Q06190 P2R3A_HUMAN 3.00E-130 GO:0090244; GO:0005509; GO:0001754; GO:0090090; GO:0090263; GO:0045732; GO:0006470; GO:0000159; GO:0008601; GO:0090249; GO:0007525; GO:0061053 Q969G9 Wnt receptor signaling pathway involved in somitogenesis; calcium ion binding; eye photoreceptor cell differentiation; negative regulation of canonical Wnt receptor signaling pathway; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of protein catabolic process; protein dephosphorylation; protein phosphatase type 2A complex; protein phosphatase type 2A regulator activity; regulation of cell motility involved in somitogenic axis elongation; somatic muscle development; somite development IPR011992; IPR018247; IPR002048; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B''-PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B) PPP2R3A PPP2R3 Homo sapiens (Human) TR37706_c0_g1_i1 Q91ZW7 C209E_MOUSE 2.00E-13 GO:0006897; GO:0016021; GO:0005537 endocytosis; integral to membrane; mannose binding IPR001304; IPR016186; IPR018378; IPR016187; CD209 antigen-like protein E (DC-SIGN-related protein 4) (DC-SIGNR4) (CD antigen CD209) Cd209e Mus musculus (Mouse) TR37706_c1_g2_i1 Q08CX5 TBC24_XENTR 6.00E-63 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; IPR006571; TBC1 domain family member 24 tbc1d24 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37707_c0_g2_i10 Q6PFY9 CC14B_MOUSE 2.00E-161 GO:0006281; GO:0031572; GO:0051488; GO:0031965; GO:0005730; GO:0005654; GO:0006470; GO:0004722; GO:0004725; GO:0008138 DNA repair; G2 DNA damage checkpoint; activation of anaphase-promoting complex activity; nuclear membrane; nucleolus; nucleoplasm; protein dephosphorylation; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR020422; IPR026068; IPR000387; IPR016130; Dual specificity protein phosphatase CDC14B (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog B) Cdc14b Mus musculus (Mouse) TR37707_c0_g2_i12 Q9UNH5 CC14A_HUMAN 0 GO:0007049; GO:0051301; GO:0008283; GO:0005813; GO:0005737; GO:0005634; GO:0035335; GO:0004721; GO:0004725; GO:0008138; GO:0005819 cell cycle; cell division; cell proliferation; centrosome; cytoplasm; nucleus; peptidyl-tyrosine dephosphorylation; phosphoprotein phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; spindle IPR000340; IPR020422; IPR026068; IPR000387; IPR016130; Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) CDC14A Homo sapiens (Human) TR37707_c0_g2_i14 Q6NT99 DUS23_MOUSE 8.00E-11 GO:0005829; GO:0005634; GO:0035335; GO:0004725; GO:0008138 cytosol; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR016130; Dual specificity protein phosphatase 23 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular mass dual specificity phosphatase 3) (LDP-3) Dusp23 Ldp3 Mus musculus (Mouse) TR37707_c0_g2_i2 O60729 CC14B_HUMAN 1.00E-167 GO:0006281; GO:0031572; GO:0051488; GO:0031965; GO:0005730; GO:0005654; GO:0004722; GO:0004725; GO:0008138 Q8IXJ6 DNA repair; G2 DNA damage checkpoint; activation of anaphase-promoting complex activity; nuclear membrane; nucleolus; nucleoplasm; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR020422; IPR026068; IPR000387; IPR016130; Dual specificity protein phosphatase CDC14B (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog B) CDC14B Homo sapiens (Human) TR37707_c0_g2_i3 Q9UNH5 CC14A_HUMAN 0 GO:0007049; GO:0051301; GO:0008283; GO:0005813; GO:0005737; GO:0005634; GO:0035335; GO:0004721; GO:0004725; GO:0008138; GO:0005819 cell cycle; cell division; cell proliferation; centrosome; cytoplasm; nucleus; peptidyl-tyrosine dephosphorylation; phosphoprotein phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; spindle IPR000340; IPR020422; IPR026068; IPR000387; IPR016130; Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) CDC14A Homo sapiens (Human) TR37707_c0_g2_i4 O60729 CC14B_HUMAN 1.00E-167 GO:0006281; GO:0031572; GO:0051488; GO:0031965; GO:0005730; GO:0005654; GO:0004722; GO:0004725; GO:0008138 Q8IXJ6 DNA repair; G2 DNA damage checkpoint; activation of anaphase-promoting complex activity; nuclear membrane; nucleolus; nucleoplasm; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR020422; IPR026068; IPR000387; IPR016130; Dual specificity protein phosphatase CDC14B (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog B) CDC14B Homo sapiens (Human) TR37707_c0_g2_i6 Q9UNH5 CC14A_HUMAN 0 GO:0007049; GO:0051301; GO:0008283; GO:0005813; GO:0005737; GO:0005634; GO:0035335; GO:0004721; GO:0004725; GO:0008138; GO:0005819 cell cycle; cell division; cell proliferation; centrosome; cytoplasm; nucleus; peptidyl-tyrosine dephosphorylation; phosphoprotein phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; spindle IPR000340; IPR020422; IPR026068; IPR000387; IPR016130; Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) CDC14A Homo sapiens (Human) TR37707_c0_g2_i7 A4D256 CC14C_HUMAN 6.00E-161 GO:0016021; GO:0005730; GO:0035335; GO:0004725; GO:0008138 integral to membrane; nucleolus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR020422; IPR026068; IPR000387; IPR016130; Dual specificity protein phosphatase CDC14C (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog C) CDC14C CDC14B2 Homo sapiens (Human) TR37707_c0_g2_i8 Q9UNH5 CC14A_HUMAN 0 GO:0007049; GO:0051301; GO:0008283; GO:0005813; GO:0005737; GO:0005634; GO:0035335; GO:0004721; GO:0004725; GO:0008138; GO:0005819 cell cycle; cell division; cell proliferation; centrosome; cytoplasm; nucleus; peptidyl-tyrosine dephosphorylation; phosphoprotein phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; spindle IPR000340; IPR020422; IPR026068; IPR000387; IPR016130; Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) CDC14A Homo sapiens (Human) TR37707_c0_g2_i9 Q6NT99 DUS23_MOUSE 3.00E-11 GO:0005829; GO:0005634; GO:0035335; GO:0004725; GO:0008138 cytosol; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR016130; Dual specificity protein phosphatase 23 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular mass dual specificity phosphatase 3) (LDP-3) Dusp23 Ldp3 Mus musculus (Mouse) TR37708_c1_g3_i4 Q96LR7 CB050_HUMAN 3.00E-16 Uncharacterized protein C2orf50 C2orf50 Homo sapiens (Human) TR37709_c6_g1_i1 Q9WVK0 ATRAP_MOUSE 6.00E-14 GO:0000139; GO:0004945; GO:0005938; GO:0030659; GO:0005789; GO:0016021; GO:0005886; GO:0008217; GO:0001666 P29754 Golgi membrane; angiotensin type II receptor activity; cell cortex; cytoplasmic vesicle membrane; endoplasmic reticulum membrane; integral to membrane; plasma membrane; regulation of blood pressure; response to hypoxia IPR009436; Type-1 angiotensin II receptor-associated protein (AT1 receptor-associated protein) Agtrap Atrap Mus musculus (Mouse) TR37709_c6_g1_i4 Q5EBF8 ATRAP_XENTR 6.00E-15 GO:0016021 integral to membrane IPR009436; Type-1 angiotensin II receptor-associated protein-like agtrap TGas011p03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37709_c6_g1_i7 Q5EBF8 ATRAP_XENTR 5.00E-16 GO:0016021 integral to membrane IPR009436; Type-1 angiotensin II receptor-associated protein-like agtrap TGas011p03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37711_c0_g1_i1 A8MPS7 YDJC_HUMAN 2.00E-62 GO:0005975; GO:0016810 "carbohydrate metabolic process; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds" IPR011330; IPR002509; IPR006879; UPF0249 protein ydjC homolog YDJC Homo sapiens (Human) TR37711_c0_g1_i2 Q14BV6 YDJC_MOUSE 2.00E-29 GO:0005975; GO:0016810 "carbohydrate metabolic process; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds" IPR011330; IPR002509; IPR006879; UPF0249 protein ydjC homolog Ydjc Mus musculus (Mouse) TR37711_c1_g1_i1 Q6DIM3 TBD_XENTR 4.00E-176 GO:0005525; GO:0003924; GO:0005814; GO:0005874; GO:0007017; GO:0005634; GO:0051258; GO:0005200 GTP binding; GTPase activity; centriole; microtubule; microtubule-based process; nucleus; protein polymerization; structural constituent of cytoskeleton IPR002967; IPR008280; IPR000217; IPR023123; IPR017975; IPR003008; Tubulin delta chain (Delta-tubulin) tubd1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37712_c0_g1_i1 Q9MB58 F26_ARATH 3.00E-99 GO:0003873; GO:0005524; GO:0005829; GO:0006003; GO:0006002; GO:0006000; GO:0004331; GO:0005886; GO:0043609; GO:2001070 "6-phosphofructo-2-kinase activity; ATP binding; cytosol; fructose 2,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; fructose metabolic process; fructose-2,6-bisphosphate 2-phosphatase activity; plasma membrane; regulation of carbon utilization; starch binding" IPR003094; IPR013079; IPR016260; IPR013784; IPR002044; IPR013078; IPR013783; IPR027417; IPR001345; "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (6PF-2-K/Fru-2,6-P2ase) (AtF2KP) (PFK/FBPase) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" FKFBP F2KP At1g07110 F10K1.19 Arabidopsis thaliana (Mouse-ear cress) TR37712_c0_g1_i10 Q91309 F26_LITCT 4.00E-172 GO:0003873; GO:0005524; GO:0006003; GO:0006000; GO:0004331 "6-phosphofructo-2-kinase activity; ATP binding; fructose 2,6-bisphosphate metabolic process; fructose metabolic process; fructose-2,6-bisphosphate 2-phosphatase activity" IPR003094; IPR013079; IPR016260; IPR013078; IPR027417; IPR001345; "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (6PF-2-K/Fru-2,6-P2ase) (PFK/FBPase) (6PF-2-K/Fru-2,6-P2ase liver/muscle isozymes) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) TR37712_c0_g1_i2 P70266 F261_MOUSE 0 GO:0003873; GO:0043540; GO:0005524; GO:0006003; GO:0006000; GO:0004331; GO:0070095; GO:0031100; GO:0033133; GO:0051591; GO:0033762; GO:0051384; GO:0032868; GO:0042594 "6-phosphofructo-2-kinase activity; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex; ATP binding; fructose 2,6-bisphosphate metabolic process; fructose metabolic process; fructose-2,6-bisphosphate 2-phosphatase activity; fructose-6-phosphate binding; organ regeneration; positive regulation of glucokinase activity; response to cAMP; response to glucagon stimulus; response to glucocorticoid stimulus; response to insulin stimulus; response to starvation" IPR003094; IPR013079; IPR016260; IPR013078; IPR027417; IPR001345; "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (6PF-2-K/Fru-2,6-P2ase 1) (PFK/FBPase 1) (6PF-2-K/Fru-2,6-P2ase liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" Pfkfb1 Mus musculus (Mouse) TR37712_c0_g1_i3 Q91309 F26_LITCT 0 GO:0003873; GO:0005524; GO:0006003; GO:0006000; GO:0004331 "6-phosphofructo-2-kinase activity; ATP binding; fructose 2,6-bisphosphate metabolic process; fructose metabolic process; fructose-2,6-bisphosphate 2-phosphatase activity" IPR003094; IPR013079; IPR016260; IPR013078; IPR027417; IPR001345; "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (6PF-2-K/Fru-2,6-P2ase) (PFK/FBPase) (6PF-2-K/Fru-2,6-P2ase liver/muscle isozymes) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) TR37712_c0_g1_i5 P07953 F261_RAT 0 GO:0003873; GO:0043540; GO:0005524; GO:0006003; GO:0006000; GO:0004331; GO:0070095; GO:0042802; GO:0031100; GO:0033133; GO:0051591; GO:0033762; GO:0051384; GO:0032868; GO:0042594 Itself "6-phosphofructo-2-kinase activity; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex; ATP binding; fructose 2,6-bisphosphate metabolic process; fructose metabolic process; fructose-2,6-bisphosphate 2-phosphatase activity; fructose-6-phosphate binding; identical protein binding; organ regeneration; positive regulation of glucokinase activity; response to cAMP; response to glucagon stimulus; response to glucocorticoid stimulus; response to insulin stimulus; response to starvation" IPR003094; IPR013079; IPR016260; IPR013078; IPR027417; IPR001345; "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (6PF-2-K/Fru-2,6-P2ase 1) (PFK/FBPase 1) (6PF-2-K/Fru-2,6-P2ase liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" Pfkfb1 Rattus norvegicus (Rat) TR37712_c0_g1_i7 Q9MB58 F26_ARATH 3.00E-100 GO:0003873; GO:0005524; GO:0005829; GO:0006003; GO:0006002; GO:0006000; GO:0004331; GO:0005886; GO:0043609; GO:2001070 "6-phosphofructo-2-kinase activity; ATP binding; cytosol; fructose 2,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; fructose metabolic process; fructose-2,6-bisphosphate 2-phosphatase activity; plasma membrane; regulation of carbon utilization; starch binding" IPR003094; IPR013079; IPR016260; IPR013784; IPR002044; IPR013078; IPR013783; IPR027417; IPR001345; "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (6PF-2-K/Fru-2,6-P2ase) (AtF2KP) (PFK/FBPase) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" FKFBP F2KP At1g07110 F10K1.19 Arabidopsis thaliana (Mouse-ear cress) TR37712_c0_g1_i8 Q91309 F26_LITCT 0 GO:0003873; GO:0005524; GO:0006003; GO:0006000; GO:0004331 "6-phosphofructo-2-kinase activity; ATP binding; fructose 2,6-bisphosphate metabolic process; fructose metabolic process; fructose-2,6-bisphosphate 2-phosphatase activity" IPR003094; IPR013079; IPR016260; IPR013078; IPR027417; IPR001345; "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (6PF-2-K/Fru-2,6-P2ase) (PFK/FBPase) (6PF-2-K/Fru-2,6-P2ase liver/muscle isozymes) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) TR37712_c0_g1_i9 Q06137 YL345_YEAST 1.00E-43 GO:0003873; GO:0005524; GO:0005737; GO:0006003; GO:0006000; GO:0004331; GO:0006110 P32604; P48240; Q06168 "6-phosphofructo-2-kinase activity; ATP binding; cytoplasm; fructose 2,6-bisphosphate metabolic process; fructose metabolic process; fructose-2,6-bisphosphate 2-phosphatase activity; regulation of glycolysis" IPR003094; IPR013079; IPR016260; IPR013078; IPR027417; "Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345W [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" YLR345W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR37715_c0_g1_i2 Q6B9X6 VWKA_DICDI 1.00E-10 GO:0005524; GO:0005516; GO:0031164; GO:0000331; GO:0005829; GO:0000281; GO:0031038; GO:0018209; GO:0018107; GO:0048471; GO:0004674; GO:0031156; GO:0031288 ATP binding; calmodulin binding; contractile vacuolar membrane; contractile vacuole; cytosol; mitotic cytokinesis; myosin II filament organization; peptidyl-serine modification; peptidyl-threonine phosphorylation; perinuclear region of cytoplasm; protein serine/threonine kinase activity; regulation of sorocarp development; sorocarp morphogenesis IPR011009; IPR004166; IPR002035; Alpha-protein kinase vwkA (EC 2.7.11.1) (von Willebrand factor A alpha-kinase) (vWF kinase) vwkA DDB_G0268144 Dictyostelium discoideum (Slime mold) TR37716_c0_g1_i1 Q99LM2 CK5P3_MOUSE 5.00E-92 GO:0045944; GO:0071569; GO:0000079 positive regulation of transcription from RNA polymerase II promoter; protein ufmylation; regulation of cyclin-dependent protein serine/threonine kinase activity IPR008491; CDK5 regulatory subunit-associated protein 3 Cdk5rap3 Mus musculus (Mouse) TR37717_c0_g1_i1 Q50L41 PA24F_MOUSE 1.00E-51 GO:0050482; GO:0047498; GO:0071236; GO:0071407; GO:0005829; GO:0004622; GO:0005765; GO:0046872; GO:0009395; GO:0001516; GO:0032587; GO:0031982 arachidonic acid secretion; calcium-dependent phospholipase A2 activity; cellular response to antibiotic; cellular response to organic cyclic compound; cytosol; lysophospholipase activity; lysosomal membrane; metal ion binding; phospholipid catabolic process; prostaglandin biosynthetic process; ruffle membrane; vesicle IPR016035; IPR000008; IPR002642; Cytosolic phospholipase A2 zeta (cPLA2-zeta) (EC 3.1.1.4) (Phospholipase A2 group IVF) Pla2g4f Mus musculus (Mouse) TR37717_c0_g1_i2 P0C871 PA24B_MOUSE 2.00E-36 GO:0030659; GO:0005829; GO:0046872; GO:0004623; GO:0009395 cytoplasmic vesicle membrane; cytosol; metal ion binding; phospholipase A2 activity; phospholipid catabolic process IPR016035; IPR000008; IPR002642; Cytosolic phospholipase A2 beta (cPLA2-beta) (EC 3.1.1.4) (Phospholipase A2 group IVB) Pla2g4b Mus musculus (Mouse) TR37717_c0_g1_i3 Q9TT38 PA24A_RABIT 2.00E-40 GO:0005509; GO:0005544; GO:0016023; GO:0004622; GO:0004623; GO:0009395 calcium ion binding; calcium-dependent phospholipid binding; cytoplasmic membrane-bounded vesicle; lysophospholipase activity; phospholipase A2 activity; phospholipid catabolic process IPR016035; IPR000008; IPR002642; Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] PLA2G4A CPLA2 PLA2G4 Oryctolagus cuniculus (Rabbit) TR3772_c0_g1_i1 Q4R4P6 MTO1_MACFA 3.00E-15 GO:0050660; GO:0005739; GO:0055114; GO:0002098 flavin adenine dinucleotide binding; mitochondrion; oxidation-reduction process; tRNA wobble uridine modification IPR013027; IPR004416; IPR026904; IPR002218; IPR020595; "Protein MTO1 homolog, mitochondrial" MTO1 QtrA-12602 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR37721_c0_g1_i1 P38024 PUR6_CHICK 3.00E-139 GO:0006189; GO:0034023; GO:0005524; GO:0005829; GO:0004638; GO:0004639; GO:0006144 'de novo' IMP biosynthetic process; 5-(carboxyamino)imidazole ribonucleotide mutase activity; ATP binding; cytosol; phosphoribosylaminoimidazole carboxylase activity; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; purine nucleobase metabolic process IPR013816; IPR000031; IPR018236; Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1. Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)] AIRC Gallus gallus (Chicken) TR37722_c0_g1_i1 P12078 HSP73_PLAFA 1.00E-83 GO:0005524; GO:0006950 ATP binding; response to stress IPR013126; Heat shock 70 kDa protein PPF203 (Fragment) Plasmodium falciparum TR37722_c0_g1_i3 O97125 HSP68_DROME 0 GO:0005524; GO:0008340; GO:0005811; GO:0005875; GO:0022008; GO:0031427; GO:0042594 ATP binding; determination of adult lifespan; lipid particle; microtubule associated complex; neurogenesis; response to methotrexate; response to starvation IPR018181; IPR013126; Heat shock protein 68 Hsp68 CG5436 Drosophila melanogaster (Fruit fly) TR37722_c0_g1_i4 P11146 HSP7B_DROME 0 GO:0005524; GO:0006950 ATP binding; response to stress IPR018181; IPR013126; Heat shock 70 kDa protein cognate 2 (Heat shock 70 kDa protein 87D) Hsc70-2 Hsc2 CG7756 Drosophila melanogaster (Fruit fly) TR37722_c0_g1_i6 P27541 HSP70_BRUMA 0 GO:0005524; GO:0006950 ATP binding; response to stress IPR018181; IPR013126; Heat shock 70 kDa protein HSP70 Brugia malayi (Filarial nematode worm) TR37722_c0_g1_i7 P14834 HSP70_LEIMA 1.00E-156 GO:0005524; GO:0006950 ATP binding; response to stress IPR018181; IPR013126; Heat shock 70 kDa protein (Fragment) HSP70 Leishmania major TR37722_c0_g1_i8 O97125 HSP68_DROME 0 GO:0005524; GO:0008340; GO:0005811; GO:0005875; GO:0022008; GO:0031427; GO:0042594 ATP binding; determination of adult lifespan; lipid particle; microtubule associated complex; neurogenesis; response to methotrexate; response to starvation IPR018181; IPR013126; Heat shock protein 68 Hsp68 CG5436 Drosophila melanogaster (Fruit fly) TR37723_c2_g2_i1 Q64449 MRC2_MOUSE 2.00E-19 GO:0030246; GO:0009986; GO:0005518; GO:0006897; GO:0016021; GO:0005886 carbohydrate binding; cell surface; collagen binding; endocytosis; integral to membrane; plasma membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; C-type mannose receptor 2 (Lectin lambda) (Macrophage mannose receptor 2) (CD antigen CD280) Mrc2 Kiaa0709 Mus musculus (Mouse) TR37723_c2_g2_i10 Q95L88 SFTPA_HORSE 4.00E-12 GO:0030246; GO:0005581; GO:0005615; GO:0046872; GO:0007585 carbohydrate binding; collagen; extracellular space; metal ion binding; respiratory gaseous exchange IPR001304; IPR016186; IPR018378; IPR016187; Pulmonary surfactant-associated protein A (PSAP) (PSP-A) (SP-A) SFTPA1 Equus caballus (Horse) TR37723_c2_g2_i2 Q4TU93 MRC2_RAT 3.00E-21 GO:0030246; GO:0006897; GO:0016021; GO:0005886 carbohydrate binding; endocytosis; integral to membrane; plasma membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR019931; IPR000772; C-type mannose receptor 2 (Endocytic receptor 180) (Macrophage mannose receptor 2) (CD antigen CD280) Mrc2 Endo180 Rattus norvegicus (Rat) TR37723_c2_g2_i4 Q9BWP8 COL11_HUMAN 2.00E-17 GO:0005581; GO:0032502; GO:0005576; GO:0005537; GO:0007275 collagen; developmental process; extracellular region; mannose binding; multicellular organismal development IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-11 (Collectin kidney protein 1) (CL-K1) COLEC11 UNQ596/PRO1182 Homo sapiens (Human) TR37723_c2_g2_i5 Q9UBG0 MRC2_HUMAN 2.00E-20 GO:0030246; GO:0006897; GO:0016021 carbohydrate binding; endocytosis; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; C-type mannose receptor 2 (C-type lectin domain family 13 member E) (Endocytic receptor 180) (Macrophage mannose receptor 2) (Urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (Urokinase receptor-associated protein) (CD antigen CD280) MRC2 CLEC13E ENDO180 KIAA0709 UPARAP Homo sapiens (Human) TR37723_c2_g2_i6 Q5M8X6 COL10_XENTR 4.00E-15 GO:0005581; GO:0005537 collagen; mannose binding IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-10 colec10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37723_c2_g2_i7 Q3SXB8 COL11_MOUSE 6.00E-17 GO:0005581; GO:0032502; GO:0005537; GO:0007275 collagen; developmental process; mannose binding; multicellular organismal development IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-11 (Collectin kidney protein 1) (CL-K1) Colec11 Mus musculus (Mouse) TR37723_c2_g2_i8 P13608 PGCA_BOVIN 2.00E-16 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 Q9UNA0; P49747 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Bos taurus (Bovine) TR37723_c2_g2_i9 P22897 MRC1_HUMAN 2.00E-13 GO:0010008; GO:0005887; GO:0005537; GO:0004872; GO:0006898 endosome membrane; integral to plasma membrane; mannose binding; receptor activity; receptor-mediated endocytosis IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206) MRC1 CLEC13D CLEC13DL MRC1L1 Homo sapiens (Human) TR37725_c0_g1_i1 Q8VE99 CC115_MOUSE 2.00E-15 GO:0005768; GO:0005764 endosome; lysosome Coiled-coil domain-containing protein 115 (Coiled-coil protein 1) (Ccp1) Ccdc115 Mus musculus (Mouse) TR37725_c1_g2_i1 Q6UW60 PCSK4_HUMAN 4.00E-78 GO:0002080; GO:0007340; GO:0007339; GO:0016021; GO:0006508; GO:0004252; GO:0048240 acrosomal membrane; acrosome reaction; binding of sperm to zona pellucida; integral to membrane; proteolysis; serine-type endopeptidase activity; sperm capacitation IPR006212; IPR008979; IPR009030; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 4 (EC 3.4.21.-) (Proprotein convertase 4) (PC4) PCSK4 PC4 UNQ2757/PRO6496 Homo sapiens (Human) TR37725_c1_g2_i2 Q63415 PCSK6_RAT 3.00E-80 GO:0005794; GO:0005615; GO:0016486; GO:0006508; GO:0004252 Golgi apparatus; extracellular space; peptide hormone processing; proteolysis; serine-type endopeptidase activity IPR000742; IPR006212; IPR008979; IPR009030; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR010909; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4) Pcsk6 Pace4 Rattus norvegicus (Rat) TR37725_c1_g2_i3 Q63415 PCSK6_RAT 3.00E-80 GO:0005794; GO:0005615; GO:0016486; GO:0006508; GO:0004252 Golgi apparatus; extracellular space; peptide hormone processing; proteolysis; serine-type endopeptidase activity IPR000742; IPR006212; IPR008979; IPR009030; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR010909; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4) Pcsk6 Pace4 Rattus norvegicus (Rat) TR37725_c1_g2_i4 Q9UM47 NOTC3_HUMAN 7.00E-07 GO:0000139; GO:0007220; GO:0007219; GO:0005509; GO:0005829; GO:0005789; GO:0005576; GO:0030900; GO:0072104; GO:0016021; GO:0045665; GO:0048663; GO:0005654; GO:0005886; GO:0048661; GO:0006355; GO:0006367 Q9R1P4 "Golgi membrane; Notch receptor processing; Notch signaling pathway; calcium ion binding; cytosol; endoplasmic reticulum membrane; extracellular region; forebrain development; glomerular capillary formation; integral to membrane; negative regulation of neuron differentiation; neuron fate commitment; nucleoplasm; plasma membrane; positive regulation of smooth muscle cell proliferation; regulation of transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022331; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] NOTCH3 Homo sapiens (Human) TR37725_c1_g2_i6 P16519 NEC2_HUMAN 1.00E-74 GO:0044267; GO:0030425; GO:0009790; GO:0034230; GO:0005615; GO:0030070; GO:0034231; GO:0016020; GO:0007399; GO:0043204; GO:0016540; GO:0006508; GO:0034774; GO:0004252; GO:0030133 cellular protein metabolic process; dendrite; embryo development; enkephalin processing; extracellular space; insulin processing; islet amyloid polypeptide processing; membrane; nervous system development; perikaryon; protein autoprocessing; proteolysis; secretory granule lumen; serine-type endopeptidase activity; transport vesicle IPR008979; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2) PCSK2 NEC2 Homo sapiens (Human) TR37726_c2_g1_i1 P16157 ANK1_HUMAN 2.00E-33 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR37726_c2_g1_i2 Q9TU71 ANKR1_RABIT 9.00E-16 GO:0005634 nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 1 (Cardiac adriamycin-responsive protein) (Cardiac ankyrin repeat protein) ANKRD1 CARP Oryctolagus cuniculus (Rabbit) TR37726_c2_g2_i1 F1N6G5 HACE1_BOVIN 1.00E-17 GO:0032580; GO:0000139; GO:0007030; GO:0017137; GO:0007049; GO:0005783; GO:0061025; GO:0070936; GO:0042787; GO:0030334; GO:0006355; GO:0006351; GO:0004842 "Golgi cisterna membrane; Golgi membrane; Golgi organization; Rab GTPase binding; cell cycle; endoplasmic reticulum; membrane fusion; protein K48-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of cell migration; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity" IPR002110; IPR020683; IPR000569; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HACE1 (EC 6.3.2.-) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) HACE1 Bos taurus (Bovine) TR37726_c2_g3_i1 Q8C0W1 ANMY1_MOUSE 9.00E-07 GO:0046872 metal ion binding IPR002110; IPR020683; IPR003409; IPR002893; Ankyrin repeat and MYND domain-containing protein 1 Ankmy1 Mus musculus (Mouse) TR37727_c14_g1_i1 Q2KI79 ANRA2_BOVIN 5.00E-07 GO:0005856; GO:0005829; GO:0030169; GO:0016020; GO:0005634 cytoskeleton; cytosol; low-density lipoprotein particle binding; membrane; nucleus IPR002110; IPR020683; Ankyrin repeat family A protein 2 ANKRA2 Bos taurus (Bovine) TR37727_c6_g1_i1 Q9J519 V216_FOWPN 4.00E-07 IPR002110; IPR020683; Putative ankyrin repeat protein FPV216 FPV216 Fowlpox virus (strain NVSL) (FPV) TR37728_c0_g1_i1 P83436 COG7_HUMAN 0 GO:0000139; GO:0017119; GO:0006886; GO:0006486; GO:0034067; GO:0050821; GO:0006890 Q9H9E3; Q9UP83; P70191 "Golgi membrane; Golgi transport complex; intracellular protein transport; protein glycosylation; protein localization to Golgi apparatus; protein stabilization; retrograde vesicle-mediated transport, Golgi to ER" IPR019335; Conserved oligomeric Golgi complex subunit 7 (COG complex subunit 7) (Component of oligomeric Golgi complex 7) COG7 UNQ3082/PRO10013 Homo sapiens (Human) TR37729_c5_g2_i2 Q91892 CLCC1_XENLA 9.00E-13 GO:0005794; GO:0005783; GO:0016021; GO:0005634 Golgi apparatus; endoplasmic reticulum; integral to membrane; nucleus IPR009231; Chloride channel CLIC-like protein 1 (Mid-1-related chloride channel protein 1) (MCLC) clcc1 Xenopus laevis (African clawed frog) TR37731_c4_g2_i1 P0CI65 NPHP3_DANRE 2.00E-18 GO:0016055; GO:0060271; GO:0072372 Wnt receptor signaling pathway; cilium morphogenesis; primary cilium IPR027417; IPR013026; IPR011990; IPR019734; Nephrocystin-3 nphp3 si:dkey-56l10.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR37731_c5_g1_i2 Q5RED8 CYLD_PONAB 5.00E-138 GO:0016055; GO:0005829; GO:0005874; GO:0042347; GO:0032088; GO:0090090; GO:0048471; GO:0005886; GO:0070536; GO:0004221; GO:0006511; GO:0004843; GO:0008270 Wnt receptor signaling pathway; cytosol; microtubule; negative regulation of NF-kappaB import into nucleus; negative regulation of NF-kappaB transcription factor activity; negative regulation of canonical Wnt receptor signaling pathway; perinuclear region of cytoplasm; plasma membrane; protein K63-linked deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity; zinc ion binding IPR000938; IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) CYLD CYLD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37731_c5_g2_i1 Q9D4P0 ARL5B_MOUSE 3.00E-102 GO:0005525; GO:0005622; GO:0007264 GTP binding; intracellular; small GTPase mediated signal transduction IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 5B (ADP-ribosylation factor-like protein 8) Arl5b Arl8 Mus musculus (Mouse) TR37733_c2_g1_i1 Q9Y6E0 STK24_HUMAN 4.00E-33 GO:0005524; GO:0006921; GO:0005829; GO:0008631; GO:0016020; GO:0046872; GO:0030336; GO:0005654; GO:0046777; GO:0004674; GO:0048679 Q9P2B4; Q9BUL8; O43815; Q9Y228 ATP binding; cellular component disassembly involved in execution phase of apoptosis; cytosol; intrinsic apoptotic signaling pathway in response to oxidative stress; membrane; metal ion binding; negative regulation of cell migration; nucleoplasm; protein autophosphorylation; protein serine/threonine kinase activity; regulation of axon regeneration IPR011009; IPR000719; IPR017441; IPR002290; Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] STK24 MST3 STK3 Homo sapiens (Human) TR37733_c2_g1_i4 O61122 SVKA_DICDI 1.00E-17 GO:0005524; GO:0015629; GO:0007049; GO:0051301; GO:0005813; GO:0032154; GO:0005737; GO:0005829; GO:0006972; GO:0046872; GO:0005634; GO:0051781; GO:0046777; GO:0004674; GO:0032956; GO:0010590; GO:0031156; GO:0005819 ATP binding; actin cytoskeleton; cell cycle; cell division; centrosome; cleavage furrow; cytoplasm; cytosol; hyperosmotic response; metal ion binding; nucleus; positive regulation of cell division; protein autophosphorylation; protein serine/threonine kinase activity; regulation of actin cytoskeleton organization; regulation of cytokinetic cell separation; regulation of sorocarp development; spindle IPR009652; IPR011009; IPR000719; IPR017441; IPR002290; Serine/threonine-protein kinase svkA (EC 2.7.11.1) (Severin kinase A) svkA DDB_G0286359 Dictyostelium discoideum (Slime mold) TR37733_c2_g2_i1 Q9P289 MST4_HUMAN 5.00E-116 GO:0005524; GO:0000139; GO:0006921; GO:0005829; GO:0000287; GO:0004672; GO:0004674; GO:0042981 Itself; Q9Y376; Q9P2B4; Q5VSL9 ATP binding; Golgi membrane; cellular component disassembly involved in execution phase of apoptosis; cytosol; magnesium ion binding; protein kinase activity; protein serine/threonine kinase activity; regulation of apoptotic process IPR011009; IPR000719; IPR017441; IPR002290; Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 4) (MST-4) (Mst3 and SOK1-related kinase) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) MST4 MASK Homo sapiens (Human) TR37735_c3_g1_i1 Q60648 SAP3_MOUSE 4.00E-10 GO:0004563; GO:0008047; GO:0006689; GO:0007611; GO:0019915; GO:0005764; GO:0005739; GO:0050885; GO:0005730; GO:0009313 beta-N-acetylhexosaminidase activity; enzyme activator activity; ganglioside catabolic process; learning or memory; lipid storage; lysosome; mitochondrion; neuromuscular process controlling balance; nucleolus; oligosaccharide catabolic process IPR003172; Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) Gm2a Mus musculus (Mouse) TR37735_c4_g2_i1 Q9UPN3 MACF1_HUMAN 0 GO:0016887; GO:0005794; GO:0043001; GO:0016055; GO:0015629; GO:0051015; GO:0005509; GO:0007050; GO:0006928; GO:0007163; GO:0001707; GO:0005874; GO:0008017; GO:0030177; GO:0006620; GO:0010632; GO:0051893; GO:0032886; GO:0032587; GO:0042060 Q9NRI5 ATPase activity; Golgi apparatus; Golgi to plasma membrane protein transport; Wnt receptor signaling pathway; actin cytoskeleton; actin filament binding; calcium ion binding; cell cycle arrest; cellular component movement; establishment or maintenance of cell polarity; mesoderm formation; microtubule; microtubule binding; positive regulation of Wnt receptor signaling pathway; posttranslational protein targeting to membrane; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of microtubule-based process; ruffle membrane; wound healing IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; IPR003108; IPR001101; IPR018159; IPR002017; "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)" MACF1 ABP620 ACF7 KIAA0465 KIAA1251 Homo sapiens (Human) TR37735_c4_g2_i10 Q5GN48 DMD_PIG 6.00E-31 GO:0005509; GO:0030054; GO:0005737; GO:0005856; GO:0045211; GO:0042383; GO:0008270 calcium ion binding; cell junction; cytoplasm; cytoskeleton; postsynaptic membrane; sarcolemma; zinc ion binding IPR001589; IPR001715; IPR016344; IPR011992; IPR015153; IPR015154; IPR018159; IPR002017; IPR001202; IPR000433; Dystrophin DMD Sus scrofa (Pig) TR37735_c4_g2_i11 Q9UPN3 MACF1_HUMAN 0 GO:0016887; GO:0005794; GO:0043001; GO:0016055; GO:0015629; GO:0051015; GO:0005509; GO:0007050; GO:0006928; GO:0007163; GO:0001707; GO:0005874; GO:0008017; GO:0030177; GO:0006620; GO:0010632; GO:0051893; GO:0032886; GO:0032587; GO:0042060 Q9NRI5 ATPase activity; Golgi apparatus; Golgi to plasma membrane protein transport; Wnt receptor signaling pathway; actin cytoskeleton; actin filament binding; calcium ion binding; cell cycle arrest; cellular component movement; establishment or maintenance of cell polarity; mesoderm formation; microtubule; microtubule binding; positive regulation of Wnt receptor signaling pathway; posttranslational protein targeting to membrane; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of microtubule-based process; ruffle membrane; wound healing IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; IPR003108; IPR001101; IPR018159; IPR002017; "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)" MACF1 ABP620 ACF7 KIAA0465 KIAA1251 Homo sapiens (Human) TR37735_c4_g2_i2 Q9UPN3 MACF1_HUMAN 0 GO:0016887; GO:0005794; GO:0043001; GO:0016055; GO:0015629; GO:0051015; GO:0005509; GO:0007050; GO:0006928; GO:0007163; GO:0001707; GO:0005874; GO:0008017; GO:0030177; GO:0006620; GO:0010632; GO:0051893; GO:0032886; GO:0032587; GO:0042060 Q9NRI5 ATPase activity; Golgi apparatus; Golgi to plasma membrane protein transport; Wnt receptor signaling pathway; actin cytoskeleton; actin filament binding; calcium ion binding; cell cycle arrest; cellular component movement; establishment or maintenance of cell polarity; mesoderm formation; microtubule; microtubule binding; positive regulation of Wnt receptor signaling pathway; posttranslational protein targeting to membrane; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of microtubule-based process; ruffle membrane; wound healing IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; IPR003108; IPR001101; IPR018159; IPR002017; "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)" MACF1 ABP620 ACF7 KIAA0465 KIAA1251 Homo sapiens (Human) TR37735_c4_g2_i3 Q91ZU6 DYST_MOUSE 0 GO:0031673; GO:0030018; GO:0015629; GO:0030424; GO:0007409; GO:0005509; GO:0007155; GO:0005938; GO:0007050; GO:0016023; GO:0031122; GO:0005789; GO:0005925; GO:0030056; GO:0016021; GO:0014704; GO:0005882; GO:0045104; GO:0009898; GO:0046907; GO:0015630; GO:0035371; GO:0051010; GO:0060053; GO:0005635; GO:0005634; GO:0097038; GO:0042803; GO:0031110; GO:0008090; GO:0042383; GO:0001725 P21807 H zone; Z disc; actin cytoskeleton; axon; axonogenesis; calcium ion binding; cell adhesion; cell cortex; cell cycle arrest; cytoplasmic membrane-bounded vesicle; cytoplasmic microtubule organization; endoplasmic reticulum membrane; focal adhesion; hemidesmosome; integral to membrane; intercalated disc; intermediate filament; intermediate filament cytoskeleton organization; internal side of plasma membrane; intracellular transport; microtubule cytoskeleton; microtubule plus end; microtubule plus-end binding; neurofilament cytoskeleton; nuclear envelope; nucleus; perinuclear endoplasmic reticulum; protein homodimerization activity; regulation of microtubule polymerization or depolymerization; retrograde axon cargo transport; sarcolemma; stress fiber IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; IPR003108; IPR001101; IPR018159; IPR002017; Dystonin (Bullous pemphigoid antigen 1) (BPA) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) (Microtubule actin cross-linking factor 2) Dst Bpag1 Macf2 Mus musculus (Mouse) TR37735_c4_g2_i4 Q9UPN3 MACF1_HUMAN 0 GO:0016887; GO:0005794; GO:0043001; GO:0016055; GO:0015629; GO:0051015; GO:0005509; GO:0007050; GO:0006928; GO:0007163; GO:0001707; GO:0005874; GO:0008017; GO:0030177; GO:0006620; GO:0010632; GO:0051893; GO:0032886; GO:0032587; GO:0042060 Q9NRI5 ATPase activity; Golgi apparatus; Golgi to plasma membrane protein transport; Wnt receptor signaling pathway; actin cytoskeleton; actin filament binding; calcium ion binding; cell cycle arrest; cellular component movement; establishment or maintenance of cell polarity; mesoderm formation; microtubule; microtubule binding; positive regulation of Wnt receptor signaling pathway; posttranslational protein targeting to membrane; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of microtubule-based process; ruffle membrane; wound healing IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; IPR003108; IPR001101; IPR018159; IPR002017; "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)" MACF1 ABP620 ACF7 KIAA0465 KIAA1251 Homo sapiens (Human) TR37735_c4_g2_i5 P11533 DMD_CHICK 9.00E-22 GO:0005509; GO:0030054; GO:0005737; GO:0005856; GO:0045211; GO:0042383; GO:0008270 calcium ion binding; cell junction; cytoplasm; cytoskeleton; postsynaptic membrane; sarcolemma; zinc ion binding IPR001589; IPR001715; IPR016344; IPR011992; IPR015153; IPR015154; IPR018159; IPR002017; IPR001202; IPR000433; Dystrophin DMD Gallus gallus (Chicken) TR37735_c4_g2_i6 Q91ZU6 DYST_MOUSE 0 GO:0031673; GO:0030018; GO:0015629; GO:0030424; GO:0007409; GO:0005509; GO:0007155; GO:0005938; GO:0007050; GO:0016023; GO:0031122; GO:0005789; GO:0005925; GO:0030056; GO:0016021; GO:0014704; GO:0005882; GO:0045104; GO:0009898; GO:0046907; GO:0015630; GO:0035371; GO:0051010; GO:0060053; GO:0005635; GO:0005634; GO:0097038; GO:0042803; GO:0031110; GO:0008090; GO:0042383; GO:0001725 P21807 H zone; Z disc; actin cytoskeleton; axon; axonogenesis; calcium ion binding; cell adhesion; cell cortex; cell cycle arrest; cytoplasmic membrane-bounded vesicle; cytoplasmic microtubule organization; endoplasmic reticulum membrane; focal adhesion; hemidesmosome; integral to membrane; intercalated disc; intermediate filament; intermediate filament cytoskeleton organization; internal side of plasma membrane; intracellular transport; microtubule cytoskeleton; microtubule plus end; microtubule plus-end binding; neurofilament cytoskeleton; nuclear envelope; nucleus; perinuclear endoplasmic reticulum; protein homodimerization activity; regulation of microtubule polymerization or depolymerization; retrograde axon cargo transport; sarcolemma; stress fiber IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; IPR003108; IPR001101; IPR018159; IPR002017; Dystonin (Bullous pemphigoid antigen 1) (BPA) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) (Microtubule actin cross-linking factor 2) Dst Bpag1 Macf2 Mus musculus (Mouse) TR37735_c4_g2_i7 D3ZHV2 MACF1_RAT 0 GO:0016887; GO:0005794; GO:0043001; GO:0016055; GO:0005509; GO:0007050; GO:0005874; GO:0030177; GO:0010632; GO:0051893; GO:0032886; GO:0032587; GO:0042060 ATPase activity; Golgi apparatus; Golgi to plasma membrane protein transport; Wnt receptor signaling pathway; calcium ion binding; cell cycle arrest; microtubule; positive regulation of Wnt receptor signaling pathway; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of microtubule-based process; ruffle membrane; wound healing IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; IPR003108; IPR001452; IPR018159; IPR002017; Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7) Macf1 Acf7 Aclp7 Macf Rattus norvegicus (Rat) TR37735_c4_g2_i8 Q9UPN3 MACF1_HUMAN 0 GO:0016887; GO:0005794; GO:0043001; GO:0016055; GO:0015629; GO:0051015; GO:0005509; GO:0007050; GO:0006928; GO:0007163; GO:0001707; GO:0005874; GO:0008017; GO:0030177; GO:0006620; GO:0010632; GO:0051893; GO:0032886; GO:0032587; GO:0042060 Q9NRI5 ATPase activity; Golgi apparatus; Golgi to plasma membrane protein transport; Wnt receptor signaling pathway; actin cytoskeleton; actin filament binding; calcium ion binding; cell cycle arrest; cellular component movement; establishment or maintenance of cell polarity; mesoderm formation; microtubule; microtubule binding; positive regulation of Wnt receptor signaling pathway; posttranslational protein targeting to membrane; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of microtubule-based process; ruffle membrane; wound healing IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; IPR003108; IPR001101; IPR018159; IPR002017; "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)" MACF1 ABP620 ACF7 KIAA0465 KIAA1251 Homo sapiens (Human) TR37735_c4_g2_i9 P13395 SPTCA_DROME 2.00E-23 GO:0005794; GO:0003779; GO:0051693; GO:0016199; GO:0016323; GO:0005509; GO:0007417; GO:0045169; GO:0045478; GO:0030727; GO:0007294; GO:0005811; GO:0042062; GO:0048790; GO:0008017; GO:0007026; GO:0031594; GO:0007274; GO:0007308; GO:0030707; GO:0007009; GO:0008360; GO:0008091; GO:0045170; GO:0030721 Golgi apparatus; actin binding; actin filament capping; axon midline choice point recognition; basolateral plasma membrane; calcium ion binding; central nervous system development; fusome; fusome organization; germarium-derived female germ-line cyst formation; germarium-derived oocyte fate determination; lipid particle; long-term strengthening of neuromuscular junction; maintenance of presynaptic active zone structure; microtubule binding; negative regulation of microtubule depolymerization; neuromuscular junction; neuromuscular synaptic transmission; oocyte construction; ovarian follicle cell development; plasma membrane organization; regulation of cell shape; spectrin; spectrosome; spectrosome organization IPR011992; IPR014837; IPR018247; IPR002048; IPR001452; IPR018159; IPR013315; IPR002017; Spectrin alpha chain alpha-Spec SPEC-A CG1977 Drosophila melanogaster (Fruit fly) TR37736_c3_g3_i3 P40560 YIA1_YEAST 4.00E-22 Q08273 IPR002110; IPR020683; IPR000210; IPR011333; IPR013069; Ankyrin repeat-containing protein YIL001W YIL001W YIA1W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR37736_c3_g3_i4 Q5XIU1 ABTB1_RAT 5.00E-161 GO:0005737; GO:0005730; GO:0005886; GO:0003746 cytoplasm; nucleolus; plasma membrane; translation elongation factor activity IPR002110; IPR020683; IPR000210; IPR011333; IPR013069; Ankyrin repeat and BTB/POZ domain-containing protein 1 Abtb1 Rattus norvegicus (Rat) TR37737_c0_g2_i1 O61491 FLOT1_DROME 0 GO:0016600; GO:0007275; GO:0005198 flotillin complex; multicellular organismal development; structural molecule activity IPR001107; IPR027705; Flotillin-1 Flo FLODM-1 CG8200 Drosophila melanogaster (Fruit fly) TR37737_c0_g3_i1 Q8LNW4 FLOT2_ORYSJ 7.00E-10 GO:0005901 caveola IPR001107; IPR027705; Flotillin-like protein 2 (Nodulin-like protein 2) FLOT2 Os10g0482700 LOC_Os10g34150 OsJ_31925 OSJNBa0012L23.46 Oryza sativa subsp. japonica (Rice) TR37737_c0_g3_i4 O61491 FLOT1_DROME 0 GO:0016600; GO:0007275; GO:0005198 flotillin complex; multicellular organismal development; structural molecule activity IPR001107; IPR027705; Flotillin-1 Flo FLODM-1 CG8200 Drosophila melanogaster (Fruit fly) TR37738_c0_g1_i1 Q5VV67 PPRC1_HUMAN 1.00E-29 GO:0003723; GO:0000166; GO:0005634; GO:0006355; GO:0006351 "RNA binding; nucleotide binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR012677; IPR000504; Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) PPRC1 KIAA0595 Homo sapiens (Human) TR37738_c0_g1_i3 Q5VV67 PPRC1_HUMAN 9.00E-30 GO:0003723; GO:0000166; GO:0005634; GO:0006355; GO:0006351 "RNA binding; nucleotide binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR012677; IPR000504; Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) PPRC1 KIAA0595 Homo sapiens (Human) TR37738_c0_g1_i4 Q9UBK2 PRGC1_HUMAN 4.00E-26 GO:0005665; GO:0016605; GO:0003723; GO:0001104; GO:0008380; GO:0050681; GO:0030521; GO:0050873; GO:0001678; GO:0034599; GO:0031490; GO:0005829; GO:0007586; GO:0019395; GO:0006094; GO:0030374; GO:0006397; GO:0007005; GO:0043524; GO:0070997; GO:0000166; GO:2001171; GO:1901857; GO:2000507; GO:0046321; GO:0045722; GO:0035066; GO:1901860; GO:0010822; GO:1901863; GO:0051091; GO:0045944; GO:0006461; GO:0050821; GO:2000310; GO:0022904; GO:0001666; GO:0014850; GO:0042594; GO:0001659; GO:0008134; GO:0006367 P62508; P42704 "DNA-directed RNA polymerase II, core complex; PML body; RNA binding; RNA polymerase II transcription cofactor activity; RNA splicing; androgen receptor binding; androgen receptor signaling pathway; brown fat cell differentiation; cellular glucose homeostasis; cellular response to oxidative stress; chromatin DNA binding; cytosol; digestion; fatty acid oxidation; gluconeogenesis; ligand-dependent nuclear receptor transcription coactivator activity; mRNA processing; mitochondrion organization; negative regulation of neuron apoptotic process; neuron death; nucleotide binding; positive regulation of ATP biosynthetic process; positive regulation of cellular respiration; positive regulation of energy homeostasis; positive regulation of fatty acid oxidation; positive regulation of gluconeogenesis; positive regulation of histone acetylation; positive regulation of mitochondrial DNA metabolic process; positive regulation of mitochondrion organization; positive regulation of muscle tissue development; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein complex assembly; protein stabilization; regulation of N-methyl-D-aspartate selective glutamate receptor activity; respiratory electron transport chain; response to hypoxia; response to muscle activity; response to starvation; temperature homeostasis; transcription factor binding; transcription initiation from RNA polymerase II promoter" IPR012677; IPR000504; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6) PPARGC1A LEM6 PGC1 PGC1A PPARGC1 Homo sapiens (Human) TR37738_c0_g1_i6 Q5VV67 PPRC1_HUMAN 1.00E-29 GO:0003723; GO:0000166; GO:0005634; GO:0006355; GO:0006351 "RNA binding; nucleotide binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR012677; IPR000504; Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) PPRC1 KIAA0595 Homo sapiens (Human) TR37738_c0_g1_i7 Q9UBK2 PRGC1_HUMAN 4.00E-26 GO:0005665; GO:0016605; GO:0003723; GO:0001104; GO:0008380; GO:0050681; GO:0030521; GO:0050873; GO:0001678; GO:0034599; GO:0031490; GO:0005829; GO:0007586; GO:0019395; GO:0006094; GO:0030374; GO:0006397; GO:0007005; GO:0043524; GO:0070997; GO:0000166; GO:2001171; GO:1901857; GO:2000507; GO:0046321; GO:0045722; GO:0035066; GO:1901860; GO:0010822; GO:1901863; GO:0051091; GO:0045944; GO:0006461; GO:0050821; GO:2000310; GO:0022904; GO:0001666; GO:0014850; GO:0042594; GO:0001659; GO:0008134; GO:0006367 P62508; P42704 "DNA-directed RNA polymerase II, core complex; PML body; RNA binding; RNA polymerase II transcription cofactor activity; RNA splicing; androgen receptor binding; androgen receptor signaling pathway; brown fat cell differentiation; cellular glucose homeostasis; cellular response to oxidative stress; chromatin DNA binding; cytosol; digestion; fatty acid oxidation; gluconeogenesis; ligand-dependent nuclear receptor transcription coactivator activity; mRNA processing; mitochondrion organization; negative regulation of neuron apoptotic process; neuron death; nucleotide binding; positive regulation of ATP biosynthetic process; positive regulation of cellular respiration; positive regulation of energy homeostasis; positive regulation of fatty acid oxidation; positive regulation of gluconeogenesis; positive regulation of histone acetylation; positive regulation of mitochondrial DNA metabolic process; positive regulation of mitochondrion organization; positive regulation of muscle tissue development; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein complex assembly; protein stabilization; regulation of N-methyl-D-aspartate selective glutamate receptor activity; respiratory electron transport chain; response to hypoxia; response to muscle activity; response to starvation; temperature homeostasis; transcription factor binding; transcription initiation from RNA polymerase II promoter" IPR012677; IPR000504; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6) PPARGC1A LEM6 PGC1 PGC1A PPARGC1 Homo sapiens (Human) TR37739_c1_g1_i1 Q1KKV8 MFSD5_TAKRU 4.00E-53 GO:0016021; GO:0006810 integral to membrane; transport IPR008509; IPR016196; Molybdate-anion transporter (Major facilitator superfamily domain-containing protein 5) (Molybdate transporter 2 homolog) mfsd5 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR37739_c1_g1_i2 Q08B29 MFSD5_XENLA 6.00E-46 GO:0016021; GO:0006810 integral to membrane; transport IPR008509; IPR016196; Molybdate-anion transporter (Major facilitator superfamily domain-containing protein 5) (Molybdate transporter 2 homolog) mfsd5 Xenopus laevis (African clawed frog) TR37739_c1_g1_i4 Q6N075 MFSD5_HUMAN 6.00E-58 GO:0016021; GO:0006810 integral to membrane; transport IPR008509; IPR016196; Molybdate-anion transporter (Major facilitator superfamily domain-containing protein 5) (Molybdate transporter 2 homolog) (hsMOT2) MFSD5 UNQ832/PRO1759 Homo sapiens (Human) TR37741_c3_g1_i1 Q96EP0 RNF31_HUMAN 2.00E-19 GO:0035631; GO:0023035; GO:0071797; GO:0050852; GO:0005737; GO:0009898; GO:0043123; GO:0051092; GO:0097039; GO:0043130; GO:0004842; GO:0008270 Q9QYP6; Q9BYM8; Q9H0F6; P84022; Q4VA12 CD40 receptor complex; CD40 signaling pathway; LUBAC complex; T cell receptor signaling pathway; cytoplasm; internal side of plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; protein linear polyubiquitination; ubiquitin binding; ubiquitin-protein ligase activity; zinc ion binding IPR018997; IPR026254; IPR009060; IPR015940; IPR002867; IPR001876; IPR001841; IPR017907; E3 ubiquitin-protein ligase RNF31 (EC 6.3.2.-) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) RNF31 ZIBRA Homo sapiens (Human) TR37742_c0_g1_i1 F7BWT7 TSN15_MOUSE 8.00E-09 GO:0016021 integral to membrane IPR000301; IPR018499; IPR008952; Tetraspanin-15 (Tspan-15) (Transmembrane 4 superfamily member 15) Tspan15 Mus musculus (Mouse) TR37743_c5_g3_i2 Q925U4 EDEM1_MOUSE 0 GO:0030433; GO:0005509; GO:0030176; GO:0051787; GO:0006986 ER-associated protein catabolic process; calcium ion binding; integral to endoplasmic reticulum membrane; misfolded protein binding; response to unfolded protein IPR001382; ER degradation-enhancing alpha-mannosidase-like protein 1 Edem1 Edem Mus musculus (Mouse) TR37744_c1_g2_i1 B2GUZ1 UBP4_RAT 0 GO:0005737; GO:0046872; GO:0031397; GO:0005634; GO:0016579; GO:0034394; GO:0031647; GO:0004221; GO:0006511; GO:0004843 cytoplasm; metal ion binding; negative regulation of protein ubiquitination; nucleus; protein deubiquitination; protein localization to cell surface; regulation of protein stability; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR006615; IPR018200; IPR001394; IPR028135; IPR028134; Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) Usp4 Rattus norvegicus (Rat) TR37744_c1_g2_i2 B2GUZ1 UBP4_RAT 0 GO:0005737; GO:0046872; GO:0031397; GO:0005634; GO:0016579; GO:0034394; GO:0031647; GO:0004221; GO:0006511; GO:0004843 cytoplasm; metal ion binding; negative regulation of protein ubiquitination; nucleus; protein deubiquitination; protein localization to cell surface; regulation of protein stability; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR006615; IPR018200; IPR001394; IPR028135; IPR028134; Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) Usp4 Rattus norvegicus (Rat) TR37745_c3_g1_i2 O44252 ROST_DROME 3.00E-06 GO:0016021; GO:0016020; GO:0007520; GO:0007519 integral to membrane; membrane; myoblast fusion; skeletal muscle tissue development IPR006838; Protein rolling stone rost CG9552 Drosophila melanogaster (Fruit fly) TR37746_c3_g2_i3 Q8VE97 SRSF4_MOUSE 1.00E-07 GO:0003723; GO:0008380; GO:0006397; GO:0048025; GO:0016607; GO:0000166 "RNA binding; RNA splicing; mRNA processing; negative regulation of mRNA splicing, via spliceosome; nuclear speck; nucleotide binding" IPR012677; IPR000504; "Serine/arginine-rich splicing factor 4 (Splicing factor, arginine/serine-rich 4)" Srsf4 Sfrs4 MNCb-2616 Mus musculus (Mouse) TR37748_c1_g2_i1 B1H1P9 PPAL_XENLA 1.00E-78 GO:0003993; GO:0016021; GO:0043202; GO:0005765 acid phosphatase activity; integral to membrane; lysosomal lumen; lysosomal membrane IPR000560; Lysosomal acid phosphatase (LAP) (EC 3.1.3.2) acp2 Xenopus laevis (African clawed frog) TR37749_c4_g1_i1 Q9CZA6 NDE1_MOUSE 8.00E-67 GO:0051301; GO:0051298; GO:0021987; GO:0032154; GO:0000777; GO:0005737; GO:0005874; GO:0008017; GO:0007020; GO:0007067; GO:0007405; GO:0001764; GO:0031616; GO:0047496 Q155P7; O14576; P43034 cell division; centrosome duplication; cerebral cortex development; cleavage furrow; condensed chromosome kinetochore; cytoplasm; microtubule; microtubule binding; microtubule nucleation; mitosis; neuroblast proliferation; neuron migration; spindle pole centrosome; vesicle transport along microtubule IPR006964; Nuclear distribution protein nudE homolog 1 (NudE) (mNudE) Nde1 Nude Mus musculus (Mouse) TR37750_c3_g1_i3 Q08DI8 PUS7_BOVIN 2.00E-160 GO:0003723; GO:0009982; GO:0001522; GO:0008033 RNA binding; pseudouridine synthase activity; pseudouridine synthesis; tRNA processing IPR020103; IPR001656; IPR020119; IPR017091; IPR011760; Pseudouridylate synthase 7 homolog (EC 5.4.99.-) PUS7 Bos taurus (Bovine) TR37751_c6_g1_i1 O60343 TBCD4_HUMAN 5.00E-43 GO:0005097; GO:0032869; GO:0030659; GO:0032851; GO:0016192 Rab GTPase activator activity; cellular response to insulin stimulus; cytoplasmic vesicle membrane; positive regulation of Rab GTPase activity; vesicle-mediated transport IPR021785; IPR011993; IPR006020; IPR000195; TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) TBC1D4 AS160 KIAA0603 Homo sapiens (Human) TR37753_c6_g5_i2 P78368 KC1G2_HUMAN 3.00E-176 GO:0005524; GO:0016055; GO:0005829; GO:0000287; GO:0042277; GO:0046777; GO:0004674; GO:0007165; GO:0044281; GO:0030148 ATP binding; Wnt receptor signaling pathway; cytosol; magnesium ion binding; peptide binding; protein autophosphorylation; protein serine/threonine kinase activity; signal transduction; small molecule metabolic process; sphingolipid biosynthetic process IPR022247; IPR011009; IPR000719; IPR017441; IPR008271; Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1) CSNK1G2 CK1G2 Homo sapiens (Human) TR37753_c6_g5_i3 Q62763 KC1G3_RAT 0 GO:0005524; GO:0016055; GO:0005737; GO:0001948; GO:0000287; GO:0042277; GO:0051219; GO:0046777; GO:0004674 ATP binding; Wnt receptor signaling pathway; cytoplasm; glycoprotein binding; magnesium ion binding; peptide binding; phosphoprotein binding; protein autophosphorylation; protein serine/threonine kinase activity IPR022247; IPR011009; IPR000719; IPR017441; IPR008271; Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1) Csnk1g3 Rattus norvegicus (Rat) TR37753_c6_g5_i4 P35509 KC1G3_BOVIN 3.00E-142 GO:0005524; GO:0016055; GO:0005737; GO:0004674 ATP binding; Wnt receptor signaling pathway; cytoplasm; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1) (Fragment) CSNK1G3 Bos taurus (Bovine) TR37754_c3_g1_i1 Q8NDX2 VGLU3_HUMAN 2.00E-101 GO:0005313; GO:0030054; GO:0016021; GO:0006811; GO:0043005; GO:0006836; GO:0007605; GO:0006814; GO:0015293; GO:0030672; GO:0055085 L-glutamate transmembrane transporter activity; cell junction; integral to membrane; ion transport; neuron projection; neurotransmitter transport; sensory perception of sound; sodium ion transport; symporter activity; synaptic vesicle membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8) SLC17A8 VGLUT3 Homo sapiens (Human) TR37754_c3_g1_i2 Q8NDX2 VGLU3_HUMAN 5.00E-101 GO:0005313; GO:0030054; GO:0016021; GO:0006811; GO:0043005; GO:0006836; GO:0007605; GO:0006814; GO:0015293; GO:0030672; GO:0055085 L-glutamate transmembrane transporter activity; cell junction; integral to membrane; ion transport; neuron projection; neurotransmitter transport; sensory perception of sound; sodium ion transport; symporter activity; synaptic vesicle membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8) SLC17A8 VGLUT3 Homo sapiens (Human) TR37754_c3_g1_i3 Q9NRA2 S17A5_HUMAN 4.00E-66 GO:0006865; GO:0030054; GO:0005887; GO:0005765; GO:0015136; GO:0015739; GO:0005351; GO:0030672 amino acid transport; cell junction; integral to plasma membrane; lysosomal membrane; sialic acid transmembrane transporter activity; sialic acid transport; sugar:hydrogen symporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) TR37757_c3_g1_i1 Q70JS2 KELC_ANOST 1.00E-68 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR006652; Ring canal kelch homolog (Kelch-like protein 1) [Cleaved into: Kelch short protein] kel Anopheles stephensi (Indo-Pakistan malaria mosquito) TR37757_c5_g4_i2 O95198 KLHL2_HUMAN 1.00E-163 GO:0031463; GO:0003779; GO:0015629; GO:0005737; GO:0005829; GO:0030027; GO:0016567; GO:0001726 Cul3-RING ubiquitin ligase complex; actin binding; actin cytoskeleton; cytoplasm; cytosol; lamellipodium; protein ubiquitination; ruffle IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 2 (Actin-binding protein Mayven) KLHL2 Homo sapiens (Human) TR37758_c3_g1_i1 P10394 POL4_DROME 6.00E-08 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR37759_c0_g1_i1 Q6GLT8 FAHD2_XENLA 8.00E-127 GO:0016787; GO:0046872 hydrolase activity; metal ion binding IPR002529; IPR011234; Fumarylacetoacetate hydrolase domain-containing protein 2 (EC 3.-.-.-) fahd2 fahd2a Xenopus laevis (African clawed frog) TR37759_c0_g1_i2 Q2KIB0 FAHD2_BOVIN 1.00E-109 GO:0016787; GO:0046872 hydrolase activity; metal ion binding IPR002529; IPR011234; Fumarylacetoacetate hydrolase domain-containing protein 2 (EC 3.-.-.-) FAHD2 Bos taurus (Bovine) TR37761_c0_g2_i1 Q8WMN1 GTR5_SHEEP 1.00E-45 GO:0016324; GO:0071332; GO:0005353; GO:0016021 apical plasma membrane; cellular response to fructose stimulus; fructose transmembrane transporter activity; integral to membrane IPR002442; IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5)" SLC2A5 Ovis aries (Sheep) TR37761_c0_g4_i1 O62786 GTR2_PIG 4.00E-13 GO:0008643; GO:0016021; GO:0022891 carbohydrate transport; integral to membrane; substrate-specific transmembrane transporter activity IPR020846; IPR016196; IPR005828; IPR003663; "Solute carrier family 2, facilitated glucose transporter member 2 (Glucose transporter type 2, liver) (GLUT-2) (Fragment)" SLC2A2 GLUT2 Sus scrofa (Pig) TR37761_c0_g4_i2 B4MYA4 TRET1_DROWI 3.00E-12 GO:0016021; GO:0005886; GO:0015574 integral to membrane; plasma membrane; trehalose transmembrane transporter activity IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; Facilitated trehalose transporter Tret1 Tret1 GK22112 Drosophila willistoni (Fruit fly) TR37763_c1_g1_i1 Q9NXS3 KLH28_HUMAN 1.00E-07 IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR015916; IPR017096; IPR006652; Kelch-like protein 28 (BTB/POZ domain-containing protein 5) KLHL28 BTBD5 Homo sapiens (Human) TR37764_c0_g2_i2 Q6DDZ9 K1609_XENLA 2.00E-80 IPR006571; TLD domain-containing protein 1 (TBC/LysM-associated domain-containing protein 1) tldc1 Xenopus laevis (African clawed frog) TR37764_c0_g2_i4 Q5ZJX5 K1609_CHICK 5.00E-80 IPR006571; TLD domain-containing protein 1 (TBC/LysM-associated domain-containing protein 1) TLDC1 RCJMB04_14k7 Gallus gallus (Chicken) TR37766_c0_g1_i1 Q9NYV4 CDK12_HUMAN 2.00E-156 GO:0005524; GO:0008353; GO:0008380; GO:0002944; GO:0004693; GO:0006397; GO:0019908; GO:0016607; GO:0005730; GO:0070816; GO:0046777; GO:0043405 ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; RNA splicing; cyclin K-CDK12 complex; cyclin-dependent protein serine/threonine kinase activity; mRNA processing; nuclear cyclin-dependent protein kinase holoenzyme complex; nuclear speck; nucleolus; phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; regulation of MAP kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; "Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)" CDK12 CRK7 CRKRS KIAA0904 Homo sapiens (Human) TR37766_c0_g1_i2 Q9NYV4 CDK12_HUMAN 2.00E-155 GO:0005524; GO:0008353; GO:0008380; GO:0002944; GO:0004693; GO:0006397; GO:0019908; GO:0016607; GO:0005730; GO:0070816; GO:0046777; GO:0043405 ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; RNA splicing; cyclin K-CDK12 complex; cyclin-dependent protein serine/threonine kinase activity; mRNA processing; nuclear cyclin-dependent protein kinase holoenzyme complex; nuclear speck; nucleolus; phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; regulation of MAP kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; "Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)" CDK12 CRK7 CRKRS KIAA0904 Homo sapiens (Human) TR37766_c0_g1_i4 Q9VP22 CDK12_DROME 1.00E-154 GO:0005524; GO:0008353; GO:0004693; GO:0022008; GO:0000228; GO:0019908; GO:0006909; GO:0070816; GO:0005703 ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; cyclin-dependent protein serine/threonine kinase activity; neurogenesis; nuclear chromosome; nuclear cyclin-dependent protein kinase holoenzyme complex; phagocytosis; phosphorylation of RNA polymerase II C-terminal domain; polytene chromosome puff IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 12) (dCdk12) Cdk12 CG7597 Drosophila melanogaster (Fruit fly) TR37766_c0_g1_i5 Q9NYV4 CDK12_HUMAN 2.00E-156 GO:0005524; GO:0008353; GO:0008380; GO:0002944; GO:0004693; GO:0006397; GO:0019908; GO:0016607; GO:0005730; GO:0070816; GO:0046777; GO:0043405 ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; RNA splicing; cyclin K-CDK12 complex; cyclin-dependent protein serine/threonine kinase activity; mRNA processing; nuclear cyclin-dependent protein kinase holoenzyme complex; nuclear speck; nucleolus; phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; regulation of MAP kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; "Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)" CDK12 CRK7 CRKRS KIAA0904 Homo sapiens (Human) TR37767_c2_g1_i1 P92963 RAB1C_ARATH 4.00E-48 GO:0006888; GO:0005525; GO:0005886; GO:0015031; GO:0007264; GO:0005773 ER to Golgi vesicle-mediated transport; GTP binding; plasma membrane; protein transport; small GTPase mediated signal transduction; vacuole IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein RABB1c (AtRABB1c) (Ras-related protein Rab2A) (AtRab2A) RABB1C RAB2 RAB2A At4g17170 dl4620c FCAALL.365 Arabidopsis thaliana (Mouse-ear cress) TR37767_c2_g1_i2 P40392 RIC1_ORYSJ 2.00E-54 GO:0005525; GO:0005886; GO:0015031; GO:0007264 GTP binding; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein RIC1 RIC1 Os01g0558600 LOC_Os01g37800 B1064G04.9 B1144D11.31 Oryza sativa subsp. japonica (Rice) TR37767_c2_g1_i3 Q9SEH3 RAD2C_ARATH 5.00E-57 GO:0005525; GO:0005794; GO:0000139; GO:0005829; GO:0005886; GO:0009506; GO:0009555; GO:0009860; GO:0015031; GO:0007264; GO:0005773; GO:0016192 GTP binding; Golgi apparatus; Golgi membrane; cytosol; plasma membrane; plasmodesma; pollen development; pollen tube growth; protein transport; small GTPase mediated signal transduction; vacuole; vesicle-mediated transport IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein RABD2c (AtRABD2c) (Ras-related protein Rab1C) (AtRab1C) RABD2C RAB1C At4g17530 dl4800c FCAALL.87 Arabidopsis thaliana (Mouse-ear cress) TR37767_c2_g1_i4 Q75J93 CPAS1_DICDI 1.00E-09 GO:0030127; GO:0006888; GO:0005525; GO:0003924; GO:0006886; GO:0007264; GO:0008270 COPII vesicle coat; ER to Golgi vesicle-mediated transport; GTP binding; GTPase activity; intracellular protein transport; small GTPase mediated signal transduction; zinc ion binding IPR027417; IPR005225; IPR001806; IPR020849; IPR002035; IPR006895; Circularly permutated Ras protein 1 (DdiCPRas1) cpras1 DDB_G0277381 Dictyostelium discoideum (Slime mold) TR37771_c0_g1_i1 Q57648 RPOD_METJA 2.00E-10 GO:0003677; GO:0003899; GO:0000428; GO:0006351 Q57832 "DNA binding; DNA-directed RNA polymerase activity; DNA-directed RNA polymerase complex; transcription, DNA-dependent" IPR001514; IPR011262; IPR011263; IPR009025; IPR022842; DNA-directed RNA polymerase subunit D (EC 2.7.7.6) rpoD MJ0192 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR37771_c0_g1_i2 Q3T0Q3 RPB3_BOVIN 4.00E-156 GO:0003677; GO:0005665; GO:0003899; GO:0015630; GO:0006366 "DNA binding; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase activity; microtubule cytoskeleton; transcription from RNA polymerase II promoter" IPR001514; IPR011262; IPR011263; IPR009025; DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II subunit C) POLR2C Bos taurus (Bovine) TR37771_c0_g1_i3 P16370 RPB3_YEAST 3.00E-33 GO:0003677; GO:0005665; GO:0003899; GO:0046872; GO:0006369 P38902; P08518 "DNA binding; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase activity; metal ion binding; termination of RNA polymerase II transcription" IPR001514; IPR011262; IPR011263; IPR009025; DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (B44.5) (DNA-directed RNA polymerase II 45 kDa polypeptide) RPB3 YIL021W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR37771_c0_g1_i4 Q3T0Q3 RPB3_BOVIN 2.00E-111 GO:0003677; GO:0005665; GO:0003899; GO:0015630; GO:0006366 "DNA binding; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase activity; microtubule cytoskeleton; transcription from RNA polymerase II promoter" IPR001514; IPR011262; IPR011263; IPR009025; DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II subunit C) POLR2C Bos taurus (Bovine) TR37772_c1_g3_i1 Q76G19 PDZD4_HUMAN 3.00E-49 GO:0005938 cell cortex IPR001478; PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein) PDZD4 KIAA1444 PDZK4 PDZRN4L Homo sapiens (Human) TR37772_c1_g4_i1 Q69ZS0 PZRN3_MOUSE 7.00E-46 GO:0031594; GO:0007528; GO:0004842; GO:0008270 neuromuscular junction; neuromuscular junction development; ubiquitin-protein ligase activity; zinc ion binding IPR001478; IPR013323; IPR008974; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase PDZRN3 (EC 6.3.2.-) (PDZ domain-containing RING finger protein 3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) Pdzrn3 Kiaa1095 Semcap3 Mus musculus (Mouse) TR37772_c1_g4_i4 Q69ZS0 PZRN3_MOUSE 1.00E-26 GO:0031594; GO:0007528; GO:0004842; GO:0008270 neuromuscular junction; neuromuscular junction development; ubiquitin-protein ligase activity; zinc ion binding IPR001478; IPR013323; IPR008974; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase PDZRN3 (EC 6.3.2.-) (PDZ domain-containing RING finger protein 3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) Pdzrn3 Kiaa1095 Semcap3 Mus musculus (Mouse) TR37776_c0_g2_i1 O42227 HDA1B_XENLA 0 GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0005737; GO:0070932; GO:0070933; GO:0005634; GO:0006355; GO:0006351 "NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); cytoplasm; histone H3 deacetylation; histone H4 deacetylation; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000286; IPR003084; IPR023801; Probable histone deacetylase 1-B (HD1-B) (EC 3.5.1.98) (RPD3 homolog) hdac1-b Xenopus laevis (African clawed frog) TR37776_c0_g2_i2 Q9LXN8 HDA17_ARATH 1.00E-33 GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0070932; GO:0070933; GO:0005634; GO:0006355; GO:0006351 "NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone H3 deacetylation; histone H4 deacetylation; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000286; IPR023801; Histone deacetylase 17 (EC 3.5.1.98) HDA17 At3g44490 F14L2.40 Arabidopsis thaliana (Mouse-ear cress) TR37776_c0_g2_i3 P56518 HDAC1_STRPU 0 GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0005737; GO:0070932; GO:0070933; GO:0004407; GO:0000118; GO:0006355; GO:0008134; GO:0006351 "NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K18 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); cytoplasm; histone H3 deacetylation; histone H4 deacetylation; histone deacetylase activity; histone deacetylase complex; regulation of transcription, DNA-dependent; transcription factor binding; transcription, DNA-dependent" IPR000286; IPR003084; IPR023801; Histone deacetylase 1 (HD1) (EC 3.5.1.98) HDAC1 Strongylocentrotus purpuratus (Purple sea urchin) TR37777_c1_g1_i1 P24733 MYS_AEQIR 0 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR015650; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, striated muscle" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR37777_c2_g1_i1 P24733 MYS_AEQIR 5.00E-178 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR015650; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, striated muscle" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR37778_c0_g1_i1 Q9BXF9 TEKT3_HUMAN 3.00E-102 GO:0035085; GO:0005874; GO:0000226 cilium axoneme; microtubule; microtubule cytoskeleton organization IPR000435; Tektin-3 TEKT3 Homo sapiens (Human) TR37778_c0_g1_i2 Q5PPV2 TEKT4_XENLA 7.00E-163 GO:0035085; GO:0005874; GO:0000226 cilium axoneme; microtubule; microtubule cytoskeleton organization IPR000435; Tektin-4 tekt4 Xenopus laevis (African clawed frog) TR37779_c0_g1_i1 Q921T2 TOIP1_MOUSE 5.00E-13 GO:0016021; GO:0005635; GO:0005637; GO:0071763; GO:0034504 integral to membrane; nuclear envelope; nuclear inner membrane; nuclear membrane organization; protein localization to nucleus IPR008662; Torsin-1A-interacting protein 1 (Lamina-associated polypeptide 1B) (LAP1B) Tor1aip1 Mus musculus (Mouse) TR37779_c0_g1_i3 Q8BYU6 TOIP2_MOUSE 2.00E-18 GO:0005783; GO:0005789; GO:0016021; GO:0005635 endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nuclear envelope IPR008662; Torsin-1A-interacting protein 2 Tor1aip2 Mus musculus (Mouse) TR37780_c1_g1_i11 P89116 CASP1_SPOFR 2.00E-50 GO:0006915; GO:0004197; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-1 (EC 3.4.22.-) [Cleaved into: Caspase-1 subunit p19/18; Caspase-1 subunit p12] Spodoptera frugiperda (Fall armyworm) TR37780_c1_g1_i2 O01382 ICE_DROME 2.00E-41 GO:0004197; GO:0010623; GO:0016322; GO:0045476; GO:0046672; GO:0006508; GO:0010165; GO:0035070; GO:0048515; GO:0035103 Q9XYF4 cysteine-type endopeptidase activity; developmental programmed cell death; neuron remodeling; nurse cell apoptotic process; positive regulation of compound eye retinal cell programmed cell death; proteolysis; response to X-ray; salivary gland histolysis; spermatid differentiation; sterol regulatory element binding protein cleavage IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase (EC 3.4.22.-) (drICE) [Cleaved into: Caspase subunit p21; Caspase subunit p12] Ice CG7788 Drosophila melanogaster (Fruit fly) TR37780_c1_g1_i3 Q92851 CASPA_HUMAN 9.00E-45 GO:0097190; GO:0004197; GO:0005829; GO:0045087; GO:0005886; GO:0043123; GO:0006508; GO:0042981; GO:0097342 Q14790; O15519; O14730; Q13546 apoptotic signaling pathway; cysteine-type endopeptidase activity; cytosol; innate immune response; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteolysis; regulation of apoptotic process; ripoptosome IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] CASP10 MCH4 Homo sapiens (Human) TR37780_c1_g1_i5 Q9XYF4 ICENC_DROME 3.00E-26 GO:0006919; GO:0007417; GO:0048749; GO:0004197; GO:0005737; GO:0048813; GO:0008340; GO:0035234; GO:0008258; GO:0007516; GO:0035081; GO:0008285; GO:0016322; GO:0045476; GO:0046672; GO:0016540; GO:0042803; GO:0006508; GO:0035071; GO:0007291; GO:0031638 O01382; Q24306 activation of cysteine-type endopeptidase activity involved in apoptotic process; central nervous system development; compound eye development; cysteine-type endopeptidase activity; cytoplasm; dendrite morphogenesis; determination of adult lifespan; germ cell programmed cell death; head involution; hemocyte development; induction of programmed cell death by hormones; negative regulation of cell proliferation; neuron remodeling; nurse cell apoptotic process; positive regulation of compound eye retinal cell programmed cell death; protein autoprocessing; protein homodimerization activity; proteolysis; salivary gland cell autophagic cell death; sperm individualization; zymogen activation IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase Nc (EC 3.4.22.-) (NEDD2-like caspase DRONC) [Cleaved into: Caspase Nc subunit 1; Caspase Nc subunit 2] Nc CG8091 Drosophila melanogaster (Fruit fly) TR37780_c1_g1_i7 Q14790 CASP8_HUMAN 2.00E-57 GO:0031265; GO:0030690; GO:0035666; GO:0006919; GO:0001525; GO:0044297; GO:0006921; GO:0071260; GO:0005813; GO:0097153; GO:0005829; GO:0031264; GO:0097191; GO:0007507; GO:0045087; GO:0097193; GO:0030225; GO:0045121; GO:0005741; GO:0019048; GO:0043124; GO:0001841; GO:0043005; GO:0070423; GO:0005634; GO:0043123; GO:0045651; GO:1900740; GO:0045862; GO:0051291; GO:0051603; GO:2001239; GO:0046677; GO:0032025; GO:0009409; GO:0032355; GO:0045471; GO:0032496; GO:0034612; GO:0097342; GO:0034138; GO:0034142 P51572; Q92851; Q9UKL3; O15519-1; Q13618; Q13158; P25445; P48023; Q13418; Q9UDY8; O60936; P29350; Q13546; O00220 CD95 death-inducing signaling complex; Noc1p-Noc2p complex; TRIF-dependent toll-like receptor signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cell body; cellular component disassembly involved in execution phase of apoptosis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; cytosol; death-inducing signaling complex; extrinsic apoptotic signaling pathway; heart development; innate immune response; intrinsic apoptotic signaling pathway; macrophage differentiation; membrane raft; mitochondrial outer membrane; modulation by virus of host morphology or physiology; negative regulation of I-kappaB kinase/NF-kappaB cascade; neural tube formation; neuron projection; nucleotide-binding oligomerization domain containing signaling pathway; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macrophage differentiation; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of proteolysis; protein heterooligomerization; proteolysis involved in cellular protein catabolic process; regulation of extrinsic apoptotic signaling pathway in absence of ligand; response to antibiotic; response to cobalt ion; response to cold; response to estradiol stimulus; response to ethanol; response to lipopolysaccharide; response to tumor necrosis factor; ripoptosome; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] CASP8 MCH5 Homo sapiens (Human) TR37780_c1_g1_i9 Q14790 CASP8_HUMAN 3.00E-57 GO:0031265; GO:0030690; GO:0035666; GO:0006919; GO:0001525; GO:0044297; GO:0006921; GO:0071260; GO:0005813; GO:0097153; GO:0005829; GO:0031264; GO:0097191; GO:0007507; GO:0045087; GO:0097193; GO:0030225; GO:0045121; GO:0005741; GO:0019048; GO:0043124; GO:0001841; GO:0043005; GO:0070423; GO:0005634; GO:0043123; GO:0045651; GO:1900740; GO:0045862; GO:0051291; GO:0051603; GO:2001239; GO:0046677; GO:0032025; GO:0009409; GO:0032355; GO:0045471; GO:0032496; GO:0034612; GO:0097342; GO:0034138; GO:0034142 P51572; Q92851; Q9UKL3; O15519-1; Q13618; Q13158; P25445; P48023; Q13418; Q9UDY8; O60936; P29350; Q13546; O00220 CD95 death-inducing signaling complex; Noc1p-Noc2p complex; TRIF-dependent toll-like receptor signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cell body; cellular component disassembly involved in execution phase of apoptosis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; cytosol; death-inducing signaling complex; extrinsic apoptotic signaling pathway; heart development; innate immune response; intrinsic apoptotic signaling pathway; macrophage differentiation; membrane raft; mitochondrial outer membrane; modulation by virus of host morphology or physiology; negative regulation of I-kappaB kinase/NF-kappaB cascade; neural tube formation; neuron projection; nucleotide-binding oligomerization domain containing signaling pathway; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macrophage differentiation; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of proteolysis; protein heterooligomerization; proteolysis involved in cellular protein catabolic process; regulation of extrinsic apoptotic signaling pathway in absence of ligand; response to antibiotic; response to cobalt ion; response to cold; response to estradiol stimulus; response to ethanol; response to lipopolysaccharide; response to tumor necrosis factor; ripoptosome; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] CASP8 MCH5 Homo sapiens (Human) TR37781_c0_g1_i11 Q02890 PNG1_YEAST 1.00E-51 GO:0005829; GO:0003684; GO:0046872; GO:0006515; GO:0006289; GO:0005634; GO:0000224; GO:0006517 cytosol; damaged DNA binding; metal ion binding; misfolded or incompletely synthesized protein catabolic process; nucleotide-excision repair; nucleus; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity; protein deglycosylation IPR018325; IPR002931; Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (EC 3.5.1.52) (Peptide:N-glycanase 1) (yPNG1) PNG1 YPL096W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR37781_c0_g1_i12 Q5ZJM3 NGLY1_CHICK 0 GO:0005737; GO:0006516; GO:0046872; GO:0000224 cytoplasm; glycoprotein catabolic process; metal ion binding; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IPR008979; IPR006588; IPR018997; IPR006567; IPR002931; Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase) NGLY1 RCJMB04_17c15 Gallus gallus (Chicken) TR37781_c0_g1_i13 Q5ZJM3 NGLY1_CHICK 0 GO:0005737; GO:0006516; GO:0046872; GO:0000224 cytoplasm; glycoprotein catabolic process; metal ion binding; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IPR008979; IPR006588; IPR018997; IPR006567; IPR002931; Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase) NGLY1 RCJMB04_17c15 Gallus gallus (Chicken) TR37781_c0_g1_i14 Q6CAX5 PNG1_YARLI 3.00E-58 GO:0005737; GO:0003684; GO:0046872; GO:0006289; GO:0005634; GO:0000224 cytoplasm; damaged DNA binding; metal ion binding; nucleotide-excision repair; nucleus; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IPR018325; IPR002931; Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (EC 3.5.1.52) (Peptide:N-glycanase 1) PNG1 YALI0C23562g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR37781_c0_g1_i15 Q5WNE3 NGLY1_CAEBR 5.00E-91 GO:0045454; GO:0005737; GO:0005783; GO:0006662; GO:0006516; GO:0046872; GO:0000224; GO:0015035 cell redox homeostasis; cytoplasm; endoplasmic reticulum; glycerol ether metabolic process; glycoprotein catabolic process; metal ion binding; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity; protein disulfide oxidoreductase activity IPR008979; IPR006588; IPR005746; IPR012336; IPR017937; IPR013766; IPR002931; Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (EC 3.5.1.52) (Peptide:N-glycanase) (PNGase) png-1 CBG08042 Caenorhabditis briggsae TR37781_c0_g1_i2 Q5ZJM3 NGLY1_CHICK 0 GO:0005737; GO:0006516; GO:0046872; GO:0000224 cytoplasm; glycoprotein catabolic process; metal ion binding; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IPR008979; IPR006588; IPR018997; IPR006567; IPR002931; Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase) NGLY1 RCJMB04_17c15 Gallus gallus (Chicken) TR37781_c0_g1_i4 Q5ZJM3 NGLY1_CHICK 0 GO:0005737; GO:0006516; GO:0046872; GO:0000224 cytoplasm; glycoprotein catabolic process; metal ion binding; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IPR008979; IPR006588; IPR018997; IPR006567; IPR002931; Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase) NGLY1 RCJMB04_17c15 Gallus gallus (Chicken) TR37781_c0_g1_i6 Q7F0R1 PNG1_ORYSJ 7.00E-71 GO:0005737; GO:0046872; GO:0000224 cytoplasm; metal ion binding; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IPR002931; Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (EC 3.5.1.52) (Peptide:N-glycanase) PNG1 Os07g0497400 LOC_Os07g31460 OJ1197_D06.103 P0005E02.110 Oryza sativa subsp. japonica (Rice) TR37781_c0_g1_i9 Q59Q38 PNG1_CANAL 6.00E-45 GO:0005737; GO:0003684; GO:0046872; GO:0006289; GO:0005634; GO:0000224 cytoplasm; damaged DNA binding; metal ion binding; nucleotide-excision repair; nucleus; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IPR018325; Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (EC 3.5.1.52) (Peptide:N-glycanase 1) PNG1 CaO19.26 CaO19.7697 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) TR37781_c0_g2_i2 Q5XIU9 PGRC2_RAT 8.00E-54 GO:0020037; GO:0016021; GO:0005496 heme binding; integral to membrane; steroid binding IPR001199; Membrane-associated progesterone receptor component 2 Pgrmc2 Rattus norvegicus (Rat) TR37782_c0_g1_i1 Q7SYI5 C1GTB_DANRE 4.00E-96 GO:0016266; GO:0001525; GO:0016263; GO:0016021; GO:0001822; GO:0046872 O-glycan processing; angiogenesis; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity; integral to membrane; kidney development; metal ion binding IPR026842; IPR003378; Protein modification; protein glycosylation. "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-B (EC 2.4.1.122) (Core 1 O-glycan T-synthase B) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1-B) (Core 1 beta1,3-galactosyltransferase 1-B) (C1GalT1-B) (Core 1 beta3-Gal-T1-B)" c1galt1b c1galt1 zgc:66485 Danio rerio (Zebrafish) (Brachydanio rerio) TR37782_c0_g1_i2 Q86X52 CHSS1_HUMAN 5.00E-13 GO:0032580; GO:0000139; GO:0050510; GO:0005975; GO:0030206; GO:0005576; GO:0047238; GO:0016021; GO:0046872; GO:0030279; GO:0031667 Golgi cisterna membrane; Golgi membrane; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity; carbohydrate metabolic process; chondroitin sulfate biosynthetic process; extracellular region; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity; integral to membrane; metal ion binding; negative regulation of ossification; response to nutrient levels IPR008428; Chondroitin sulfate synthase 1 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 1) (Chondroitin synthase 1) (ChSy-1) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1) (N-acetylgalactosaminyltransferase 1) CHSY1 CHSY CSS1 KIAA0990 UNQ756/PRO1487 Homo sapiens (Human) TR37782_c0_g1_i3 Q7SYI5 C1GTB_DANRE 4.00E-96 GO:0016266; GO:0001525; GO:0016263; GO:0016021; GO:0001822; GO:0046872 O-glycan processing; angiogenesis; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity; integral to membrane; kidney development; metal ion binding IPR026842; IPR003378; Protein modification; protein glycosylation. "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-B (EC 2.4.1.122) (Core 1 O-glycan T-synthase B) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1-B) (Core 1 beta1,3-galactosyltransferase 1-B) (C1GalT1-B) (Core 1 beta3-Gal-T1-B)" c1galt1b c1galt1 zgc:66485 Danio rerio (Zebrafish) (Brachydanio rerio) TR37783_c0_g1_i2 Q8NDA8 HTR7A_HUMAN 0 IPR011989; IPR016024; IPR000357; IPR021133; Maestro heat-like repeat-containing protein family member 1 (HEAT repeat-containing protein 7A) MROH1 HEATR7A KIAA1833 Homo sapiens (Human) TR37784_c0_g1_i1 Q86U44 MTA70_HUMAN 0 GO:0003723; GO:0010467; GO:0016422; GO:0016607; GO:0005654 RNA binding; gene expression; mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; nuclear speck; nucleoplasm IPR025848; IPR007757; N6-adenosine-methyltransferase 70 kDa subunit (MT-A70) (EC 2.1.1.62) (Methyltransferase-like protein 3) METTL3 MTA70 Homo sapiens (Human) TR37784_c0_g1_i2 Q86U44 MTA70_HUMAN 0 GO:0003723; GO:0010467; GO:0016422; GO:0016607; GO:0005654 RNA binding; gene expression; mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; nuclear speck; nucleoplasm IPR025848; IPR007757; N6-adenosine-methyltransferase 70 kDa subunit (MT-A70) (EC 2.1.1.62) (Methyltransferase-like protein 3) METTL3 MTA70 Homo sapiens (Human) TR37786_c0_g1_i1 P51448 RORA_MOUSE 2.00E-12 GO:0003677; GO:0046068; GO:0021702; GO:0030522; GO:0004879; GO:0006809; GO:0005654; GO:0045944; GO:0043030; GO:0043565; GO:0003700; GO:0003707; GO:0008270 P54254; Q9QYH6 DNA binding; cGMP metabolic process; cerebellar Purkinje cell differentiation; intracellular receptor signaling pathway; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nitric oxide biosynthetic process; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; regulation of macrophage activation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; zinc ion binding IPR008946; IPR000536; IPR003079; IPR001723; IPR001628; IPR013088; Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (Retinoid-related orphan receptor-alpha) Rora Nr1f1 Rzra Mus musculus (Mouse) TR37786_c4_g1_i1 P35398 RORA_HUMAN 1.00E-09 GO:0046068; GO:0021702; GO:0004879; GO:0006809; GO:0005654; GO:0045944; GO:0043030; GO:0043565; GO:0003707; GO:0006367; GO:0008270 P51843 cGMP metabolic process; cerebellar Purkinje cell differentiation; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nitric oxide biosynthetic process; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; regulation of macrophage activation; sequence-specific DNA binding; steroid hormone receptor activity; transcription initiation from RNA polymerase II promoter; zinc ion binding IPR008946; IPR000536; IPR003079; IPR001723; IPR001628; IPR013088; Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (Retinoid-related orphan receptor-alpha) RORA NR1F1 RZRA Homo sapiens (Human) TR37787_c0_g1_i1 Q6DG03 DMTF1_DANRE 2.00E-132 GO:0003677; GO:0007049; GO:0003682; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cell cycle; chromatin binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009057; IPR017877; IPR017930; IPR001005; Cyclin-D-binding Myb-like transcription factor 1 dmtf1 si:dkey-153k10.8 zgc:92448 Danio rerio (Zebrafish) (Brachydanio rerio) TR37788_c0_g2_i2 Q49AM3 TTC31_HUMAN 7.00E-13 IPR013026; IPR011990; IPR013105; IPR019734; Tetratricopeptide repeat protein 31 (TPR repeat protein 31) TTC31 Homo sapiens (Human) TR37790_c0_g2_i1 A8QCE4 LST2_BRUMA 1.00E-13 GO:0046872 metal ion binding IPR000306; IPR017455; IPR011011; IPR013083; Lateral signaling target protein 2 homolog Bm1_49520 Brugia malayi (Filarial nematode worm) TR37790_c0_g2_i2 A8QCE4 LST2_BRUMA 1.00E-13 GO:0046872 metal ion binding IPR000306; IPR017455; IPR011011; IPR013083; Lateral signaling target protein 2 homolog Bm1_49520 Brugia malayi (Filarial nematode worm) TR37793_c2_g1_i3 Q6P9X4 TP4A2_RAT 9.00E-71 GO:0005769; GO:0035335; GO:0005886; GO:0004725 early endosome; peptidyl-tyrosine dephosphorylation; plasma membrane; protein tyrosine phosphatase activity IPR000387; IPR000242; Protein tyrosine phosphatase type IVA 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) Ptp4a2 Prl2 Rattus norvegicus (Rat) TR37793_c2_g1_i5 Q6P9X4 TP4A2_RAT 9.00E-71 GO:0005769; GO:0035335; GO:0005886; GO:0004725 early endosome; peptidyl-tyrosine dephosphorylation; plasma membrane; protein tyrosine phosphatase activity IPR000387; IPR000242; Protein tyrosine phosphatase type IVA 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) Ptp4a2 Prl2 Rattus norvegicus (Rat) TR37793_c5_g3_i1 P19572 DCDA_PSEAE 2.00E-18 GO:0004040; GO:0006520; GO:0008836; GO:0009089; GO:0030170 amidase activity; cellular amino acid metabolic process; diaminopimelate decarboxylase activity; lysine biosynthetic process via diaminopimelate; pyridoxal phosphate binding IPR009006; IPR002986; IPR022643; IPR022644; IPR022653; IPR000183; "Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1." Diaminopimelate decarboxylase (DAP decarboxylase) (DAPDC) (EC 4.1.1.20) lysA PA5277 Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) TR37793_c5_g3_i4 P27117 DCOR_BOVIN 1.00E-82 GO:0004586; GO:0033387 ornithine decarboxylase activity; putrescine biosynthetic process from ornithine IPR009006; IPR022643; IPR022657; IPR022644; IPR022653; IPR000183; IPR002433; Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1. Ornithine decarboxylase (ODC) (EC 4.1.1.17) ODC1 ODC Bos taurus (Bovine) TR37795_c0_g2_i1 Q9HCD5 NCOA5_HUMAN 9.00E-15 GO:0005634; GO:0006355; GO:0006351 Q60674 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR004154; Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) NCOA5 KIAA1637 Homo sapiens (Human) TR37795_c0_g2_i11 Q9HCD5 NCOA5_HUMAN 4.00E-37 GO:0005634; GO:0006355; GO:0006351 Q60674 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR004154; Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) NCOA5 KIAA1637 Homo sapiens (Human) TR37795_c0_g2_i6 Q9HCD5 NCOA5_HUMAN 3.00E-37 GO:0005634; GO:0006355; GO:0006351 Q60674 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR004154; Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) NCOA5 KIAA1637 Homo sapiens (Human) TR37795_c0_g3_i1 Q08DJ0 RALYL_BOVIN 3.00E-06 GO:0003723; GO:0000166 RNA binding; nucleotide binding IPR017347; IPR012677; IPR000504; RNA-binding Raly-like protein RALYL Bos taurus (Bovine) TR37796_c1_g3_i1 P09759 EPHB1_RAT 0 GO:0005524; GO:0001525; GO:0030424; GO:0008046; GO:0048593; GO:0060326; GO:0031589; GO:0021952; GO:0030425; GO:0060997; GO:0050965; GO:0031901; GO:0030010; GO:0005887; GO:0045121; GO:0061351; GO:0021631; GO:0051965; GO:0046777; GO:0070372; GO:0046328; GO:0031290; GO:0005005 ATP binding; angiogenesis; axon; axon guidance receptor activity; camera-type eye morphogenesis; cell chemotaxis; cell-substrate adhesion; central nervous system projection neuron axonogenesis; dendrite; dendritic spine morphogenesis; detection of temperature stimulus involved in sensory perception of pain; early endosome membrane; establishment of cell polarity; integral to plasma membrane; membrane raft; neural precursor cell proliferation; optic nerve morphogenesis; positive regulation of synapse assembly; protein autophosphorylation; regulation of ERK1 and ERK2 cascade; regulation of JNK cascade; retinal ganglion cell axon guidance; transmembrane-ephrin receptor activity IPR027936; IPR001090; IPR003961; IPR008979; IPR009030; IPR013783; IPR011009; IPR000719; IPR017441; IPR001660; IPR013761; IPR021129; IPR001245; IPR008266; IPR020635; IPR016257; IPR001426; Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (Tyrosine-protein kinase receptor EPH-2) Ephb1 Elk Epth2 Rattus norvegicus (Rat) TR37796_c1_g3_i5 P28693 EPHB2_CHICK 7.00E-118 GO:0005524; GO:0001525; GO:0030424; GO:0007411; GO:0007413; GO:0030425; GO:0060997; GO:0005887; GO:0051965; GO:0005005 P00520 ATP binding; angiogenesis; axon; axon guidance; axonal fasciculation; dendrite; dendritic spine morphogenesis; integral to plasma membrane; positive regulation of synapse assembly; transmembrane-ephrin receptor activity IPR027936; IPR001090; IPR003961; IPR008979; IPR009030; IPR013783; IPR011009; IPR000719; IPR017441; IPR001660; IPR013761; IPR021129; IPR001245; IPR011641; IPR008266; IPR020635; IPR016257; IPR001426; Ephrin type-B receptor 2 (EC 2.7.10.1) (EPH-like kinase 5) (EK5) (cEK5) EPHB2 CEK5 Gallus gallus (Chicken) TR37796_c1_g4_i1 O42422 EPHA7_CHICK 2.00E-51 GO:0005524; GO:0005004; GO:0008046; GO:0007420; GO:0048755; GO:0045499; GO:0005887; GO:0043525; GO:0070372; GO:0022407; GO:0043281; GO:0050730; GO:0031952; GO:0031290 ATP binding; GPI-linked ephrin receptor activity; axon guidance receptor activity; brain development; branching morphogenesis of a nerve; chemorepellent activity; integral to plasma membrane; positive regulation of neuron apoptotic process; regulation of ERK1 and ERK2 cascade; regulation of cell-cell adhesion; regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of peptidyl-tyrosine phosphorylation; regulation of protein autophosphorylation; retinal ganglion cell axon guidance IPR027936; IPR001090; IPR003961; IPR008979; IPR013783; IPR011009; IPR000719; IPR017441; IPR001660; IPR013761; IPR021129; IPR001245; IPR011641; IPR008266; IPR020635; IPR016257; IPR001426; Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH-like kinase 11) (EK11) (cEK11) (Tyrosine-protein kinase receptor CEPHA7) EPHA7 CEK11 Gallus gallus (Chicken) TR37799_c0_g1_i1 Q9PUQ1 ETV4_DANRE 1.00E-16 GO:0009790; GO:0035108; GO:0005634; GO:0045893; GO:0048793; GO:0043565; GO:0003700; GO:0006351 "embryo development; limb morphogenesis; nucleus; positive regulation of transcription, DNA-dependent; pronephros development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR006715; IPR011991; ETS translocation variant 4 (Polyomavirus enhancer activator 3 homolog) (Protein PEA3) etv4 pea3 Danio rerio (Zebrafish) (Brachydanio rerio) TR37799_c0_g1_i10 A1YG61 EHF_PANPA 5.00E-28 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; ETS homologous factor (ETS domain-containing transcription factor) EHF Pan paniscus (Pygmy chimpanzee) (Bonobo) TR37799_c0_g1_i12 Q1RML4 SPIC_BOVIN 1.00E-08 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR011991; Transcription factor Spi-C SPIC Bos taurus (Bovine) TR37799_c0_g1_i2 A1YG61 EHF_PANPA 6.00E-28 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; ETS homologous factor (ETS domain-containing transcription factor) EHF Pan paniscus (Pygmy chimpanzee) (Bonobo) TR37799_c0_g1_i3 Q01842 POK_DROME 9.00E-11 GO:0007254; GO:0007464; GO:0045467; GO:0003705; GO:0007298; GO:0001709; GO:0005737; GO:0048813; GO:0007391; GO:0006897; GO:0008406; GO:0048747; GO:0007517; GO:0046580; GO:0030178; GO:0046533; GO:0000122; GO:0005634; GO:0060233; GO:0045678; GO:0090175; GO:0045610; GO:0043565 JNK cascade; R3/R4 cell fate commitment; R7 cell development; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; border follicle cell migration; cell fate determination; cytoplasm; dendrite morphogenesis; dorsal closure; endocytosis; gonad development; muscle fiber development; muscle organ development; negative regulation of Ras protein signal transduction; negative regulation of Wnt receptor signaling pathway; negative regulation of photoreceptor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; nucleus; oenocyte delamination; positive regulation of R7 cell differentiation; regulation of establishment of planar polarity; regulation of hemocyte differentiation; sequence-specific DNA binding IPR000418; IPR003118; IPR013761; IPR011991; Ets DNA-binding protein pokkuri (Protein anterior open) (Protein yan) aop pok Yan CG3166 Drosophila melanogaster (Fruit fly) TR37799_c0_g1_i5 Q1RML4 SPIC_BOVIN 1.00E-08 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR011991; Transcription factor Spi-C SPIC Bos taurus (Bovine) TR37799_c0_g1_i7 Q60775 ELF1_MOUSE 5.00E-18 GO:0005737; GO:0050860; GO:0005634; GO:0045944; GO:0001817; GO:0043565; GO:0003700; GO:0006351 "cytoplasm; negative regulation of T cell receptor signaling pathway; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of cytokine production; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR022084; IPR011991; ETS-related transcription factor Elf-1 (E74-like factor 1) Elf1 Mus musculus (Mouse) TR37799_c0_g1_i9 A1YG61 EHF_PANPA 8.00E-28 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; ETS homologous factor (ETS domain-containing transcription factor) EHF Pan paniscus (Pygmy chimpanzee) (Bonobo) TR3780_c0_g1_i1 Q70E20 SNED1_MOUSE 4.00E-20 GO:0005509; GO:0007160; GO:0005576 calcium ion binding; cell-matrix adhesion; extracellular region IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003961; IPR009030; IPR013783; IPR003886; IPR000436; "Sushi, nidogen and EGF-like domain-containing protein 1 (Secreted protein SST-3) (Stromal nidogen extracellular matrix protein)" Sned1 Snep Mus musculus (Mouse) TR37801_c0_g1_i1 Q4I8X0 TRM10_GIBZE 3.00E-13 GO:0005737; GO:0005634; GO:0052905 cytoplasm; nucleus; tRNA (guanine(9)-N(1))-methyltransferase activity IPR016009; IPR007356; IPR016653; tRNA (guanine(9)-N1)-methyltransferase (EC 2.1.1.221) (tRNA methyltransferase 10) (tRNA(m1G9)-methyltransferase) (tRNA(m1G9)MTase) TRM10 FGSG_06338 Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum) TR37801_c0_g2_i1 O14214 TRM10_SCHPO 1.00E-34 GO:0005737; GO:0005730; GO:0052905 cytoplasm; nucleolus; tRNA (guanine(9)-N(1))-methyltransferase activity IPR016009; IPR007356; IPR016653; tRNA (guanine(9)-N1)-methyltransferase (EC 2.1.1.221) (tRNA methyltransferase 10) (tRNA(m1G9)-methyltransferase) (tRNA(m1G9)MTase) trm10 SPAC6B12.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR37802_c1_g1_i1 Q9ULJ6 ZMIZ1_HUMAN 8.00E-153 GO:0048844; GO:0007569; GO:0005737; GO:0048589; GO:0003007; GO:0001701; GO:0016607; GO:0048146; GO:0045944; GO:0006351; GO:0001570; GO:0007296; GO:0008270 "artery morphogenesis; cell aging; cytoplasm; developmental growth; heart morphogenesis; in utero embryonic development; nuclear speck; positive regulation of fibroblast proliferation; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; vasculogenesis; vitellogenesis; zinc ion binding" IPR004181; IPR013083; Zinc finger MIZ domain-containing protein 1 (PIAS-like protein Zimp10) (Retinoic acid-induced protein 17) ZMIZ1 KIAA1224 RAI17 ZIMP10 Homo sapiens (Human) TR37802_c1_g1_i4 Q9ULJ6 ZMIZ1_HUMAN 8.00E-153 GO:0048844; GO:0007569; GO:0005737; GO:0048589; GO:0003007; GO:0001701; GO:0016607; GO:0048146; GO:0045944; GO:0006351; GO:0001570; GO:0007296; GO:0008270 "artery morphogenesis; cell aging; cytoplasm; developmental growth; heart morphogenesis; in utero embryonic development; nuclear speck; positive regulation of fibroblast proliferation; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; vasculogenesis; vitellogenesis; zinc ion binding" IPR004181; IPR013083; Zinc finger MIZ domain-containing protein 1 (PIAS-like protein Zimp10) (Retinoic acid-induced protein 17) ZMIZ1 KIAA1224 RAI17 ZIMP10 Homo sapiens (Human) TR37803_c1_g1_i1 O46503 ST1C2_RABIT 4.00E-35 GO:0005737; GO:0008146 cytoplasm; sulfotransferase activity IPR027417; IPR000863; Sulfotransferase 1C2 (ST1C2) (rabSULT1C2) (EC 2.8.2.-) (Sulfotransferase 1C1) SULT1C2 SULT1C1 Oryctolagus cuniculus (Rabbit) TR37803_c1_g1_i2 O43704 ST1B1_HUMAN 3.00E-36 GO:0050427; GO:0004062; GO:0006576; GO:0005829; GO:0009812; GO:0008202; GO:0051923; GO:0008146; GO:0042403; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; aryl sulfotransferase activity; cellular biogenic amine metabolic process; cytosol; flavonoid metabolic process; steroid metabolic process; sulfation; sulfotransferase activity; thyroid hormone metabolic process; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) (Sulfotransferase 1B2) (ST1B2) (Thyroid hormone sulfotransferase) SULT1B1 ST1B2 SULT1B2 Homo sapiens (Human) TR37803_c1_g1_i4 Q9WUW8 ST1C2_RAT 1.00E-26 GO:0005764; GO:0008146 lysosome; sulfotransferase activity IPR027417; IPR000863; Sulfotransferase 1C2 (ST1C2) (rSULT1C2) (EC 2.8.2.-) (Sulfotransferase K1) Sult1c2 Sultk1 Rattus norvegicus (Rat) TR37804_c0_g2_i3 Q8N6F8 WBS27_HUMAN 3.00E-28 Williams-Beuren syndrome chromosomal region 27 protein WBSCR27 Homo sapiens (Human) TR37804_c0_g2_i4 Q8N6F8 WBS27_HUMAN 4.00E-28 Williams-Beuren syndrome chromosomal region 27 protein WBSCR27 Homo sapiens (Human) TR37806_c1_g1_i4 Q63406 MCF2L_RAT 3.00E-128 GO:0005089; GO:0005737; GO:0035556; GO:0005543; GO:0005886; GO:0035023 Rho guanyl-nucleotide exchange factor activity; cytoplasm; intracellular signal transduction; phospholipid binding; plasma membrane; regulation of Rho protein signal transduction IPR001251; IPR000219; IPR001331; IPR011993; IPR001849; IPR001452; IPR018159; IPR002017; Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein) (OST oncogene) Mcf2l Ost Rattus norvegicus (Rat) TR37806_c1_g2_i1 Q86YR7 MF2L2_HUMAN 1.00E-61 GO:0005089; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; phospholipid binding; regulation of Rho protein signal transduction IPR001251; IPR000219; IPR011993; IPR001849; IPR018159; Probable guanine nucleotide exchange factor MCF2L2 (Dbs-related Rho family guanine nucleotide exchange factor) (MCF2-transforming sequence-like protein 2) MCF2L2 DRG KIAA0861 Homo sapiens (Human) TR37806_c1_g2_i2 Q6GNM9 SES1B_XENLA 5.00E-19 IPR001251; IPR018159; SEC14 domain and spectrin repeat-containing protein 1-B sestd1-b Xenopus laevis (African clawed frog) TR37806_c2_g2_i1 Q09014 NCF1_MOUSE 2.00E-08 GO:0006742; GO:0007154; GO:0008283; GO:0006968; GO:0005829; GO:0050665; GO:0006954; GO:0006691; GO:0045986; GO:0070947; GO:0070946; GO:0035091; GO:0006612; GO:0002679; GO:0001878; GO:0042554; GO:0016175 NADP catabolic process; cell communication; cell proliferation; cellular defense response; cytosol; hydrogen peroxide biosynthetic process; inflammatory response; leukotriene metabolic process; negative regulation of smooth muscle contraction; neutrophil mediated killing of fungus; neutrophil mediated killing of gram-positive bacterium; phosphatidylinositol binding; protein targeting to membrane; respiratory burst involved in defense response; response to yeast; superoxide anion generation; superoxide-generating NADPH oxidase activity IPR015039; IPR001655; IPR001683; IPR001452; Neutrophil cytosol factor 1 (NCF-1) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (p47-phox) Ncf1 Mus musculus (Mouse) TR37806_c2_g2_i2 Q1DLP2 MYO1_COCIM 4.00E-10 GO:0005524; GO:0030479; GO:0003774; GO:0016459 ATP binding; actin cortical patch; motor activity; myosin complex IPR001609; IPR010926; IPR027417; IPR001452; Myosin-1 (Class I unconventional myosin) (Type I myosin) MYO1 CIMG_08771 Coccidioides immitis (strain RS) (Valley fever fungus) TR37807_c1_g3_i1 Q05B50 THG1_BOVIN 1.00E-114 GO:0005524; GO:0005525; GO:0005737; GO:0000287; GO:0005739; GO:0051289; GO:0008193; GO:0006400 ATP binding; GTP binding; cytoplasm; magnesium ion binding; mitochondrion; protein homotetramerization; tRNA guanylyltransferase activity; tRNA modification IPR025845; IPR024956; IPR007537; Probable tRNA(His) guanylyltransferase (EC 2.7.7.79) (tRNA-histidine guanylyltransferase) THG1L Bos taurus (Bovine) TR37807_c1_g3_i3 Q9V3N8 THG1_DROME 2.00E-103 GO:0005525; GO:0005737; GO:0000287; GO:0022008; GO:0008193; GO:0006400 GTP binding; cytoplasm; magnesium ion binding; neurogenesis; tRNA guanylyltransferase activity; tRNA modification IPR025845; IPR024956; IPR007537; Probable tRNA(His) guanylyltransferase (EC 2.7.7.79) (tRNA-histidine guanylyltransferase) l(2)35Bc CG4103 Drosophila melanogaster (Fruit fly) TR37807_c2_g1_i1 Q0MQC3 ACPM_PANTR 1.00E-35 GO:0006633; GO:0005739; GO:0055114; GO:0009249; GO:0070469 fatty acid biosynthetic process; mitochondrion; oxidation-reduction process; protein lipoylation; respiratory chain IPR003231; IPR009081; IPR006162; "Acyl carrier protein, mitochondrial (ACP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit)" NDUFAB1 Pan troglodytes (Chimpanzee) TR37807_c2_g1_i2 P11943 ACPM_NEUCR 1.00E-22 GO:0009107; GO:0005739; GO:0055114; GO:0070469 lipoate biosynthetic process; mitochondrion; oxidation-reduction process; respiratory chain IPR003231; IPR009081; IPR006162; Lipid metabolism; fatty acid biosynthesis. "Acyl carrier protein, mitochondrial (ACP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit)" nuo-12 acp nuo9.6 NCU05008 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR37807_c2_g1_i4 Q5SL79 ACP_THET8 5.00E-14 GO:0000036; GO:0005737 ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process; cytoplasm IPR003231; IPR009081; IPR006162; Lipid metabolism; fatty acid biosynthesis. Acyl carrier protein (ACP) acpP TTHA0414 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) TR37807_c2_g1_i8 Q0MQC3 ACPM_PANTR 2.00E-35 GO:0006633; GO:0005739; GO:0055114; GO:0009249; GO:0070469 fatty acid biosynthetic process; mitochondrion; oxidation-reduction process; protein lipoylation; respiratory chain IPR003231; IPR009081; IPR006162; "Acyl carrier protein, mitochondrial (ACP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit)" NDUFAB1 Pan troglodytes (Chimpanzee) TR37807_c2_g1_i9 Q10217 ACPM_SCHPO 7.00E-17 GO:0048037; GO:0006633; GO:0005759; GO:0055114 cofactor binding; fatty acid biosynthetic process; mitochondrial matrix; oxidation-reduction process IPR003231; IPR009081; IPR006162; Lipid metabolism; fatty acid biosynthesis. "Putative acyl carrier protein, mitochondrial (ACP)" SPAC4H3.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR37808_c0_g5_i1 P34473 YMH6_CAEEL 9.00E-18 Uncharacterized protein F58A4.6 F58A4.6 Caenorhabditis elegans TR37808_c0_g6_i1 Q6DG43 UBTD2_DANRE 4.00E-90 GO:0005737 cytoplasm IPR000626; Ubiquitin domain-containing protein 2 ubtd2 zgc:91797 Danio rerio (Zebrafish) (Brachydanio rerio) TR37811_c3_g2_i5 Q06805 TIE1_BOVIN 7.00E-06 GO:0005524; GO:0001525; GO:0016021; GO:0018108; GO:0005886; GO:0004714 ATP binding; angiogenesis; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; transmembrane receptor protein tyrosine kinase activity IPR000742; IPR013032; IPR003961; IPR013783; IPR003599; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE TIE-1 Bos taurus (Bovine) TR37811_c3_g3_i1 P35590 TIE1_HUMAN 5.00E-07 GO:0005524; GO:0001525; GO:0001701; GO:0005887; GO:0007498; GO:0016525; GO:0030336; GO:0045026; GO:0032526; GO:0004714 Q15238 ATP binding; angiogenesis; in utero embryonic development; integral to plasma membrane; mesoderm development; negative regulation of angiogenesis; negative regulation of cell migration; plasma membrane fusion; response to retinoic acid; transmembrane receptor protein tyrosine kinase activity IPR000742; IPR013032; IPR003961; IPR013783; IPR003599; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE Homo sapiens (Human) TR37812_c1_g1_i4 P25916 BMI1_MOUSE 4.00E-24 GO:0031519; GO:0007420; GO:0003682; GO:0005737; GO:0048704; GO:0016573; GO:0016574; GO:0006959; GO:0001701; GO:2001234; GO:0000122; GO:0016604; GO:0030890; GO:0033092; GO:0051443; GO:0021903; GO:0043565; GO:0048103; GO:0006351; GO:0000151; GO:0008270 Q9QXV1; Q8IXK0; Q9QWH1; O35730; Q9CQJ4 "PcG protein complex; brain development; chromatin binding; cytoplasm; embryonic skeletal system morphogenesis; histone acetylation; histone ubiquitination; humoral immune response; in utero embryonic development; negative regulation of apoptotic signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nuclear body; positive regulation of B cell proliferation; positive regulation of immature T cell proliferation in thymus; positive regulation of ubiquitin-protein ligase activity; rostrocaudal neural tube patterning; sequence-specific DNA binding; somatic stem cell division; transcription, DNA-dependent; ubiquitin ligase complex; zinc ion binding" IPR018957; IPR001841; IPR013083; IPR017907; Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) Bmi1 Bmi-1 Pcgf4 Mus musculus (Mouse) TR37812_c1_g1_i6 P25916 BMI1_MOUSE 1.00E-23 GO:0031519; GO:0007420; GO:0003682; GO:0005737; GO:0048704; GO:0016573; GO:0016574; GO:0006959; GO:0001701; GO:2001234; GO:0000122; GO:0016604; GO:0030890; GO:0033092; GO:0051443; GO:0021903; GO:0043565; GO:0048103; GO:0006351; GO:0000151; GO:0008270 Q9QXV1; Q8IXK0; Q9QWH1; O35730; Q9CQJ4 "PcG protein complex; brain development; chromatin binding; cytoplasm; embryonic skeletal system morphogenesis; histone acetylation; histone ubiquitination; humoral immune response; in utero embryonic development; negative regulation of apoptotic signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nuclear body; positive regulation of B cell proliferation; positive regulation of immature T cell proliferation in thymus; positive regulation of ubiquitin-protein ligase activity; rostrocaudal neural tube patterning; sequence-specific DNA binding; somatic stem cell division; transcription, DNA-dependent; ubiquitin ligase complex; zinc ion binding" IPR018957; IPR001841; IPR013083; IPR017907; Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) Bmi1 Bmi-1 Pcgf4 Mus musculus (Mouse) TR37812_c1_g1_i9 P25916 BMI1_MOUSE 3.00E-24 GO:0031519; GO:0007420; GO:0003682; GO:0005737; GO:0048704; GO:0016573; GO:0016574; GO:0006959; GO:0001701; GO:2001234; GO:0000122; GO:0016604; GO:0030890; GO:0033092; GO:0051443; GO:0021903; GO:0043565; GO:0048103; GO:0006351; GO:0000151; GO:0008270 Q9QXV1; Q8IXK0; Q9QWH1; O35730; Q9CQJ4 "PcG protein complex; brain development; chromatin binding; cytoplasm; embryonic skeletal system morphogenesis; histone acetylation; histone ubiquitination; humoral immune response; in utero embryonic development; negative regulation of apoptotic signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nuclear body; positive regulation of B cell proliferation; positive regulation of immature T cell proliferation in thymus; positive regulation of ubiquitin-protein ligase activity; rostrocaudal neural tube patterning; sequence-specific DNA binding; somatic stem cell division; transcription, DNA-dependent; ubiquitin ligase complex; zinc ion binding" IPR018957; IPR001841; IPR013083; IPR017907; Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) Bmi1 Bmi-1 Pcgf4 Mus musculus (Mouse) TR37814_c0_g2_i1 Q9D6H5 ZDHC4_MOUSE 6.00E-22 GO:0016021; GO:0016746; GO:0008270 "integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Probable palmitoyltransferase ZDHHC4 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 4) (DHHC-4) Zdhhc4 Mus musculus (Mouse) TR37814_c0_g2_i2 Q5FVR1 ZDHC4_RAT 4.00E-24 GO:0016021; GO:0016746; GO:0008270 "integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Probable palmitoyltransferase ZDHHC4 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 4) (DHHC-4) Zdhhc4 Rattus norvegicus (Rat) TR37814_c0_g2_i3 Q9NPG8 ZDHC4_HUMAN 4.00E-20 GO:0016021; GO:0016746; GO:0008270 "integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Probable palmitoyltransferase ZDHHC4 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 4) (DHHC-4) (Zinc finger protein 374) ZDHHC4 ZNF374 DC1 UNQ5787/PRO19576 Homo sapiens (Human) TR37815_c1_g1_i1 Q14005 IL16_HUMAN 8.00E-09 GO:0005737; GO:0005615; GO:0006955; GO:0050930; GO:0030595; GO:0019048; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "cytoplasm; extracellular space; immune response; induction of positive chemotaxis; leukocyte chemotaxis; modulation by virus of host morphology or physiology; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR020450; IPR001478; Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] IL16 Homo sapiens (Human) TR37815_c1_g2_i1 O35889 AFAD_RAT 1.00E-42 GO:0007155; GO:0005913; GO:0005829; GO:0007165 Q16643; Q8VC66 cell adhesion; cell-cell adherens junction; cytosol; signal transduction IPR018444; IPR002710; IPR000253; IPR001478; IPR000159; IPR008984; Afadin (Protein Af-6) Mllt4 Af6 Rattus norvegicus (Rat) TR37818_c1_g1_i1 P28572 SC6A9_RAT 1.00E-146 GO:0015187; GO:0005887; GO:0005328; GO:0005283 P31016 glycine transmembrane transporter activity; integral to plasma membrane; neurotransmitter:sodium symporter activity; sodium:amino acid symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) Slc6a9 Rattus norvegicus (Rat) TR37818_c1_g1_i2 Q9Y345 SC6A5_HUMAN 1.00E-173 GO:0015375; GO:0016021; GO:0005328; GO:0005886; GO:0007268 glycine:sodium symporter activity; integral to membrane; neurotransmitter:sodium symporter activity; plasma membrane; synaptic transmission IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) TR37819_c0_g1_i1 Q54UU6 KRR1_DICDI 1.00E-93 GO:0003723; GO:0005730; GO:0006364; GO:0030529 RNA binding; nucleolus; rRNA processing; ribonucleoprotein complex IPR004087; IPR024166; KRR1 small subunit processome component homolog (KRR-R motif-containing protein 1) krr1 DDB_G0280805 Dictyostelium discoideum (Slime mold) TR37819_c0_g1_i4 Q8BGA5 KRR1_MOUSE 5.00E-138 GO:0003723; GO:0005730; GO:0006364; GO:0030529 RNA binding; nucleolus; rRNA processing; ribonucleoprotein complex IPR004087; IPR004088; IPR024166; KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2 homolog) (KRR-R motif-containing protein 1) Krr1 Hrb2 Mus musculus (Mouse) TR37822_c6_g1_i1 Q94694 RAP1_PHYPO 1.00E-12 GO:0005525; GO:0003924; GO:0005886; GO:0007264 GTP binding; GTPase activity; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; Ras-related protein Rap-1 (Pprap1) RAP1 Physarum polycephalum (Slime mold) TR37822_c6_g1_i4 Q9NGC3 CEG1A_DROME 6.00E-135 GO:0008060; GO:0005525; GO:0005634; GO:0005543; GO:0032312; GO:0007264; GO:0008270 ARF GTPase activator activity; GTP binding; nucleus; phospholipid binding; regulation of ARF GTPase activity; small GTPase mediated signal transduction; zinc ion binding IPR002110; IPR020683; IPR001164; IPR013684; IPR027417; IPR011993; IPR001849; Centaurin-gamma-1A cenG1A CG31811 Drosophila melanogaster (Fruit fly) TR37822_c7_g2_i1 Q6PDG5 SMRC2_MOUSE 1.00E-21 GO:0003677; GO:0016514; GO:0003682; GO:0006338; GO:0071565; GO:0045892; GO:0007399; GO:0071564; GO:0006337; GO:0045893; GO:0006351; GO:0017053 "DNA binding; SWI/SNF complex; chromatin binding; chromatin remodeling; nBAF complex; negative regulation of transcription, DNA-dependent; nervous system development; npBAF complex; nucleosome disassembly; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; transcriptional repressor complex" IPR001357; IPR000953; IPR009057; IPR001005; IPR017884; IPR007526; IPR011991; SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) Smarcc2 Baf170 Mus musculus (Mouse) TR37822_c7_g2_i2 Q6PDG5 SMRC2_MOUSE 2.00E-20 GO:0003677; GO:0016514; GO:0003682; GO:0006338; GO:0071565; GO:0045892; GO:0007399; GO:0071564; GO:0006337; GO:0045893; GO:0006351; GO:0017053 "DNA binding; SWI/SNF complex; chromatin binding; chromatin remodeling; nBAF complex; negative regulation of transcription, DNA-dependent; nervous system development; npBAF complex; nucleosome disassembly; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; transcriptional repressor complex" IPR001357; IPR000953; IPR009057; IPR001005; IPR017884; IPR007526; IPR011991; SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) Smarcc2 Baf170 Mus musculus (Mouse) TR37824_c0_g1_i1 P38670 ERG24_NEUCR 4.00E-90 GO:0050613; GO:0016021; GO:0016126 delta14-sterol reductase activity; integral to membrane; sterol biosynthetic process IPR001171; IPR018083; Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 2/6. Delta(14)-sterol reductase (EC 1.3.1.70) (C-14 sterol reductase) (Sterol C14-reductase) erg-3 erg3 B2G14.010 NCU08762 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR37824_c0_g1_i4 Q54PP1 ERG24_DICDI 3.00E-86 GO:0050613; GO:0005789; GO:0006696; GO:0016021 delta14-sterol reductase activity; endoplasmic reticulum membrane; ergosterol biosynthetic process; integral to membrane IPR001171; Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 2/6. Delta(14)-sterol reductase (EC 1.3.1.70) (C-14 sterol reductase) (Sterol C14-reductase) erg24 DDB_G0284407 Dictyostelium discoideum (Slime mold) TR37824_c0_g1_i5 P23913 LBR_CHICK 2.00E-150 GO:0003677; GO:0016021; GO:0005637; GO:0016628 "DNA binding; integral to membrane; nuclear inner membrane; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor" IPR001171; IPR019023; IPR018083; Lamin-B receptor LBR Gallus gallus (Chicken) TR37825_c0_g2_i1 Q8I9S1 SNMP1_HELAM 4.00E-08 GO:0007155; GO:0016021; GO:0005886; GO:0050896; GO:0007608 cell adhesion; integral to membrane; plasma membrane; response to stimulus; sensory perception of smell IPR002159; Sensory neuron membrane protein 1 SNMP-1 Helicoverpa armigera (Cotton bollworm) (Heliothis armigera) TR37825_c3_g3_i1 Q69CM7 MYBPP_RAT 1.00E-50 GO:0030154; GO:0005737; GO:0019897; GO:0007275; GO:0007605; GO:0007283; GO:0007268 cell differentiation; cytoplasm; extrinsic to plasma membrane; multicellular organismal development; sensory perception of sound; spermatogenesis; synaptic transmission MYCBP-associated protein (Organ of Corti membrane-associated protein of 106 kDa) Mycbpap Cod106 Rattus norvegicus (Rat) TR37825_c4_g1_i2 P26900 ASPG1_BACSU 6.00E-07 GO:0004067; GO:0006520; GO:0005737 asparaginase activity; cellular amino acid metabolic process; cytoplasm IPR006033; IPR006034; IPR020827; IPR027475; IPR027473; IPR027474; L-asparaginase 1 (L-ASNase 1) (EC 3.5.1.1) (L-asparagine amidohydrolase 1) ansA BSU23580 Bacillus subtilis (strain 168) TR37826_c0_g1_i4 Q6NV24 PGFS_DANRE 4.00E-30 GO:0005829; GO:0016616; GO:0001516 "cytosol; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; prostaglandin biosynthetic process" IPR012336; Prostamide/prostaglandin F synthase (Prostamide/PG F synthase) (Prostamide/PGF synthase) (EC 1.11.1.20) fam213b zgc:85644 Danio rerio (Zebrafish) (Brachydanio rerio) TR37827_c2_g1_i2 Q8IZN3 ZDH14_HUMAN 4.00E-156 GO:0016021; GO:0016746; GO:0008270 "integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Probable palmitoyltransferase ZDHHC14 (EC 2.3.1.225) (NEW1 domain-containing protein) (NEW1CP) (Zinc finger DHHC domain-containing protein 14) (DHHC-14) ZDHHC14 Homo sapiens (Human) TR37827_c2_g2_i1 Q6C890 ERFB_YARLI 4.00E-48 GO:0005789; GO:0016021; GO:0016746; GO:0008270 "endoplasmic reticulum membrane; integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Palmitoyltransferase ERF2 (EC 2.3.1.225) (DHHC cysteine-rich domain-containing protein ERF2) (Ras protein acyltransferase) ERF2 YALI0D21670g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR37827_c2_g2_i2 Q8IZN3 ZDH14_HUMAN 2.00E-168 GO:0016021; GO:0016746; GO:0008270 "integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Probable palmitoyltransferase ZDHHC14 (EC 2.3.1.225) (NEW1 domain-containing protein) (NEW1CP) (Zinc finger DHHC domain-containing protein 14) (DHHC-14) ZDHHC14 Homo sapiens (Human) TR37829_c2_g1_i1 Q7JVE7 SWET1_DROME 2.00E-35 GO:0000139; GO:0016021; GO:0005886; GO:0007431; GO:0051119 Q7K3Y9 Golgi membrane; integral to membrane; plasma membrane; salivary gland development; sugar transmembrane transporter activity IPR004316; Sugar transporter SWEET1 (Protein saliva) slv CG8717 Drosophila melanogaster (Fruit fly) TR37829_c2_g1_i2 Q7JVE7 SWET1_DROME 2.00E-35 GO:0000139; GO:0016021; GO:0005886; GO:0007431; GO:0051119 Q7K3Y9 Golgi membrane; integral to membrane; plasma membrane; salivary gland development; sugar transmembrane transporter activity IPR004316; Sugar transporter SWEET1 (Protein saliva) slv CG8717 Drosophila melanogaster (Fruit fly) TR37830_c1_g1_i5 Q9UH92 MLX_HUMAN 2.00E-77 GO:0003677; GO:0005737; GO:0006112; GO:0045892; GO:0006913; GO:0005634; GO:0031325; GO:0003700; GO:0044281; GO:0006351 "DNA binding; cytoplasm; energy reserve metabolic process; negative regulation of transcription, DNA-dependent; nucleocytoplasmic transport; nucleus; positive regulation of cellular metabolic process; sequence-specific DNA binding transcription factor activity; small molecule metabolic process; transcription, DNA-dependent" IPR011598; Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4) MLX BHLHD13 TCFL4 Homo sapiens (Human) TR37830_c2_g2_i1 Q91XQ4 GRL1A_RAT 4.00E-09 GO:0016591; GO:0003899; GO:0032774 "DNA-directed RNA polymerase II, holoenzyme; DNA-directed RNA polymerase activity; RNA biosynthetic process" IPR026213; DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) Polr2m Grinl1a Rattus norvegicus (Rat) TR37831_c2_g1_i1 O70451 MOT2_MOUSE 7.00E-30 GO:0016021; GO:0005886; GO:0015355; GO:0015293 integral to membrane; plasma membrane; secondary active monocarboxylate transmembrane transporter activity; symporter activity IPR027178; IPR011701; IPR020846; IPR016196; IPR004743; Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) Slc16a7 Mct2 Mus musculus (Mouse) TR37831_c2_g1_i2 Q7RTX9 MOT14_HUMAN 4.00E-47 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR37833_c0_g1_i1 Q8BMB3 IF4E2_MOUSE 1.00E-105 GO:0005737; GO:0001701; GO:0005845; GO:0017148; GO:0003743 cytoplasm; in utero embryonic development; mRNA cap binding complex; negative regulation of translation; translation initiation factor activity IPR023398; IPR001040; IPR019770; Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (eIF4E-2) (mRNA cap-binding protein type 2) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) Eif4e2 Eif4el3 Mus musculus (Mouse) TR37833_c0_g1_i2 Q8BMB3 IF4E2_MOUSE 8.00E-109 GO:0005737; GO:0001701; GO:0005845; GO:0017148; GO:0003743 cytoplasm; in utero embryonic development; mRNA cap binding complex; negative regulation of translation; translation initiation factor activity IPR023398; IPR001040; IPR019770; Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (eIF4E-2) (mRNA cap-binding protein type 2) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) Eif4e2 Eif4el3 Mus musculus (Mouse) TR37834_c1_g1_i2 Q80V91 DTX3_MOUSE 1.00E-13 GO:0007219; GO:0005737; GO:0016874; GO:0016567; GO:0008270 Notch signaling pathway; cytoplasm; ligase activity; protein ubiquitination; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase DTX3 (EC 6.3.2.-) (Protein deltex-3) (Deltex3) (mDTX3) Dtx3 Mus musculus (Mouse) TR37834_c1_g2_i1 Q9Y2E6 DTX4_HUMAN 8.00E-55 GO:0007219; GO:0005829; GO:0045087; GO:0016874; GO:0032481; GO:0016567; GO:0008270 Notch signaling pathway; cytosol; innate immune response; ligase activity; positive regulation of type I interferon production; protein ubiquitination; zinc ion binding IPR004170; IPR018123; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DTX4 (EC 6.3.2.-) (Protein deltex-4) (Deltex4) (RING finger protein 155) DTX4 KIAA0937 RNF155 Homo sapiens (Human) TR37836_c0_g1_i2 Q92485 ASM3B_HUMAN 4.00E-95 GO:0005615; GO:0016798; GO:0006685; GO:0004767 "extracellular space; hydrolase activity, acting on glycosyl bonds; sphingomyelin catabolic process; sphingomyelin phosphodiesterase activity" IPR017064; IPR004843; Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-) SMPDL3B ASML3B Homo sapiens (Human) TR37836_c0_g1_i6 Q92485 ASM3B_HUMAN 4.00E-93 GO:0005615; GO:0016798; GO:0006685; GO:0004767 "extracellular space; hydrolase activity, acting on glycosyl bonds; sphingomyelin catabolic process; sphingomyelin phosphodiesterase activity" IPR017064; IPR004843; Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-) SMPDL3B ASML3B Homo sapiens (Human) TR37837_c1_g1_i1 Q5R7G6 PEPL1_PONAB 0 GO:0004177; GO:0005737; GO:0030145; GO:0008235; GO:0006508 aminopeptidase activity; cytoplasm; manganese ion binding; metalloexopeptidase activity; proteolysis IPR011356; IPR000819; Probable aminopeptidase NPEPL1 (EC 3.4.11.-) (Aminopeptidase-like 1) NPEPL1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37838_c0_g1_i4 Q6NWZ9 CDO1_DANRE 1.00E-79 GO:0046439; GO:0017172; GO:0005506; GO:0042412 L-cysteine metabolic process; cysteine dioxygenase activity; iron ion binding; taurine biosynthetic process IPR010300; IPR014710; IPR011051; Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2. Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I) cdo1 Danio rerio (Zebrafish) (Brachydanio rerio) TR37839_c3_g1_i2 Q8NG08 HELB_HUMAN 8.00E-79 GO:0005524; GO:0043141; GO:0006269; GO:0017116 "ATP binding; ATP-dependent 5'-3' DNA helicase activity; DNA replication, synthesis of RNA primer; single-stranded DNA-dependent ATP-dependent DNA helicase activity" IPR027044; IPR027417; IPR027785; DNA helicase B (hDHB) (EC 3.6.4.12) HELB Homo sapiens (Human) TR37840_c0_g1_i4 Q5U2Q4 PAR16_RAT 7.00E-81 GO:0003950; GO:0005789; GO:0016021; GO:0031965; GO:0006986 NAD+ ADP-ribosyltransferase activity; endoplasmic reticulum membrane; integral to membrane; nuclear membrane; response to unfolded protein IPR012317; Mono [ADP-ribose] polymerase PARP16 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 15) (ARTD15) (Poly [ADP-ribose] polymerase 16) (PARP-16) Parp16 Rattus norvegicus (Rat) TR37841_c1_g1_i1 Q5ZL79 NOL11_CHICK 9.00E-17 GO:0030490; GO:0005730; GO:1901838; GO:0006351 "maturation of SSU-rRNA; nucleolus; positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter; transcription, DNA-dependent" Nucleolar protein 11 NOL11 RCJMB04_7e21 Gallus gallus (Chicken) TR37841_c1_g3_i1 Q5RB52 NOL11_PONAB 6.00E-13 GO:0030490; GO:1901838; GO:0034455; GO:0006351 "maturation of SSU-rRNA; positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter; t-UTP complex; transcription, DNA-dependent" IPR012584; IPR017986; Nucleolar protein 11 NOL11 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37841_c1_g3_i2 Q4V9P9 NOL11_DANRE 2.00E-18 GO:0030490; GO:0005730; GO:1901838; GO:0006351 "maturation of SSU-rRNA; nucleolus; positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter; transcription, DNA-dependent" IPR017986; Nucleolar protein 11-like nol11 wu:fb30e03 zgc:109901 Danio rerio (Zebrafish) (Brachydanio rerio) TR37843_c0_g1_i1 Q8MIZ3 DCPS_PIG 1.00E-99 GO:0000340; GO:0036245; GO:0005737; GO:0000290; GO:0050072; GO:0045292; GO:0005739; GO:0043069; GO:0005634 "RNA 7-methylguanosine cap binding; cellular response to menadione; cytoplasm; deadenylation-dependent decapping of nuclear-transcribed mRNA; m7G(5')pppN diphosphatase activity; mRNA cis splicing, via spliceosome; mitochondrion; negative regulation of programmed cell death; nucleus" IPR008594; IPR019808; IPR011146; IPR011145; m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS) DCPS DCS1 HINT5 Sus scrofa (Pig) TR37843_c0_g1_i2 Q9P7C9 DCPS_SCHPO 2.00E-57 GO:0000340; GO:0000932; GO:0005829; GO:0000290; GO:0050072; GO:0005634 RNA 7-methylguanosine cap binding; cytoplasmic mRNA processing body; cytosol; deadenylation-dependent decapping of nuclear-transcribed mRNA; m7G(5')pppN diphosphatase activity; nucleus IPR008594; IPR011146; IPR011145; m7GpppX diphosphatase (EC 3.6.1.59) (Hint-related 7meGMP-directed hydrolase 1) (Nuclear histidine triad (HIT) motif protein 1) (Scavenger mRNA-decapping enzyme DcpS) nhm1 dcps SPBP4H10.20 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR37843_c0_g1_i4 Q8MIZ3 DCPS_PIG 3.00E-99 GO:0000340; GO:0036245; GO:0005737; GO:0000290; GO:0050072; GO:0045292; GO:0005739; GO:0043069; GO:0005634 "RNA 7-methylguanosine cap binding; cellular response to menadione; cytoplasm; deadenylation-dependent decapping of nuclear-transcribed mRNA; m7G(5')pppN diphosphatase activity; mRNA cis splicing, via spliceosome; mitochondrion; negative regulation of programmed cell death; nucleus" IPR008594; IPR019808; IPR011146; IPR011145; m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS) DCPS DCS1 HINT5 Sus scrofa (Pig) TR37844_c0_g1_i1 Q8AX01 MOS_DENAN 3.00E-19 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte maturation factor mos) (Fragment) MOS Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps) TR37844_c2_g1_i1 P04962 CCNA_SPISO 3.00E-58 GO:0051301; GO:0007067; GO:0005634; GO:0000079 cell division; mitosis; nucleus; regulation of cyclin-dependent protein serine/threonine kinase activity IPR013763; IPR014400; IPR004367; IPR006671; G2/mitotic-specific cyclin-A Spisula solidissima (Atlantic surf-clam) TR37844_c3_g1_i1 Q9GRC0 MOS_ASTPE 5.00E-26 GO:0005524; GO:0004709; GO:0007292; GO:0007147; GO:0045930 ATP binding; MAP kinase kinase kinase activity; female gamete generation; female meiosis II; negative regulation of mitotic cell cycle IPR011009; IPR000719; IPR017441; IPR008271; Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte maturation factor mos) mos Patiria pectinifera (Starfish) (Asterina pectinifera) TR37844_c4_g1_i1 A8WWX1 MOM4_CAEBR 3.00E-06 GO:0005524; GO:0004709; GO:0000165; GO:0016055; GO:0000186; GO:0046872; GO:0007275 ATP binding; MAP kinase kinase kinase activity; MAPK cascade; Wnt receptor signaling pathway; activation of MAPKK activity; metal ion binding; multicellular organismal development IPR011009; IPR000719; IPR017441; IPR001245; Mitogen-activated protein kinase kinase kinase mom-4 (EC 2.7.11.25) mom-4 CBG03852 Caenorhabditis briggsae TR37845_c0_g1_i1 Q7ZY85 NEPR1_XENLA 2.00E-57 GO:0071595; GO:0005737; GO:0016021; GO:0006629; GO:0031965; GO:0035307; GO:0010867 Nem1-Spo7 phosphatase complex; cytoplasm; integral to membrane; lipid metabolic process; nuclear membrane; positive regulation of protein dephosphorylation; positive regulation of triglyceride biosynthetic process IPR019168; Nuclear envelope phosphatase-regulatory subunit 1 (Transmembrane protein 188) cnep1r1 tmem188 Xenopus laevis (African clawed frog) TR37848_c1_g1_i1 Q5FWP4 CHFR_XENLA 1.00E-09 GO:0016605; GO:0051301; GO:0007067; GO:0007093; GO:0019941; GO:0000166; GO:0000209; GO:0004842; GO:0008270 Q7ZYF2 PML body; cell division; mitosis; mitotic cell cycle checkpoint; modification-dependent protein catabolic process; nucleotide binding; protein polyubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR000253; IPR008984; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) chfr Xenopus laevis (African clawed frog) TR37848_c1_g2_i1 A5WW08 CHFR_DANRE 2.00E-10 GO:0016605; GO:0051301; GO:0007067; GO:0007093; GO:0019941; GO:0000166; GO:0000209; GO:0004842; GO:0008270 PML body; cell division; mitosis; mitotic cell cycle checkpoint; modification-dependent protein catabolic process; nucleotide binding; protein polyubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR000253; IPR008984; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) chfr si:dkey-69h6.7 Danio rerio (Zebrafish) (Brachydanio rerio) TR37848_c3_g2_i1 Q810L3 CHFR_MOUSE 4.00E-62 GO:0016605; GO:0051301; GO:0007067; GO:0000278; GO:0007093; GO:0000166; GO:0000209; GO:0006511; GO:0004842; GO:0008270 PML body; cell division; mitosis; mitotic cell cycle; mitotic cell cycle checkpoint; nucleotide binding; protein polyubiquitination; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR000253; IPR008984; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) Chfr Mus musculus (Mouse) TR37850_c2_g1_i11 Q6IED8 IFI6_BOVIN 2.00E-06 GO:0016021; GO:0005739; GO:0043154; GO:2001240; GO:0051902; GO:0001836 integral to membrane; mitochondrion; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of mitochondrial depolarization; release of cytochrome c from mitochondria IPR009311; IPR016196; Interferon alpha-inducible protein 6 (Interferon-induced protein 6-16) (Ifi-6-16) IFI6 Bos taurus (Bovine) TR37850_c2_g1_i3 Q96BM0 I27L1_HUMAN 4.00E-07 GO:0016021 integral to membrane IPR009311; Interferon alpha-inducible protein 27-like protein 1 (Interferon-stimulated gene 12c protein) (ISG12(c)) IFI27L1 FAM14B Homo sapiens (Human) TR37853_c0_g1_i1 P62205 PLK1_XENTR 0 GO:0005524; GO:0031572; GO:0051301; GO:0005813; GO:0005737; GO:0000776; GO:0030496; GO:0007067; GO:0005634; GO:0071168; GO:0004674; GO:0005819 ATP binding; G2 DNA damage checkpoint; cell division; centrosome; cytoplasm; kinetochore; midbody; mitosis; nucleus; protein localization to chromatin; protein serine/threonine kinase activity; spindle IPR011009; IPR000959; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Plx1) (Polo-like kinase 1) (PLK-1) plk1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37854_c3_g2_i2 O02228 SC5A7_CAEEL 2.00E-26 GO:0008292; GO:0030424; GO:0015220; GO:0016021; GO:0043025; GO:0006814; GO:0015293; GO:0008021 acetylcholine biosynthetic process; axon; choline transmembrane transporter activity; integral to membrane; neuronal cell body; sodium ion transport; symporter activity; synaptic vesicle IPR001734; High-affinity choline transporter 1 cho-1 C48D1.3 Caenorhabditis elegans TR37854_c4_g1_i1 Q9VE46 SC5A7_DROME 9.00E-31 GO:0008292; GO:0015171; GO:0015220; GO:0016021; GO:0006814; GO:0015293 acetylcholine biosynthetic process; amino acid transmembrane transporter activity; choline transmembrane transporter activity; integral to membrane; sodium ion transport; symporter activity IPR001734; High-affinity choline transporter 1 CG7708 Drosophila melanogaster (Fruit fly) TR37854_c4_g2_i2 Q9GZV3 SC5A7_HUMAN 9.00E-70 GO:0008292; GO:0008219; GO:0033265; GO:0005307; GO:0016021; GO:0007274; GO:0043025; GO:0007269; GO:0005886; GO:0007271 "acetylcholine biosynthetic process; cell death; choline binding; choline:sodium symporter activity; integral to membrane; neuromuscular synaptic transmission; neuronal cell body; neurotransmitter secretion; plasma membrane; synaptic transmission, cholinergic" IPR001734; High affinity choline transporter 1 (Hemicholinium-3-sensitive choline transporter) (CHT) (Solute carrier family 5 member 7) SLC5A7 CHT1 Homo sapiens (Human) TR37855_c0_g1_i1 Q9UGU5 HMGX4_HUMAN 3.00E-37 GO:0003677; GO:0016589; GO:0016055; GO:0008333; GO:0030178 DNA binding; NURF complex; Wnt receptor signaling pathway; endosome to lysosome transport; negative regulation of Wnt receptor signaling pathway IPR025228; IPR009071; HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) HMGXB4 HMG2L1 HMGBCG Homo sapiens (Human) TR37860_c1_g1_i1 Q8IUK8 CBLN2_HUMAN 1.00E-06 GO:0005615; GO:0051965 extracellular space; positive regulation of synapse assembly IPR001073; IPR008983; Cerebellin-2 CBLN2 UNQ1892/PRO4338 Homo sapiens (Human) TR37860_c3_g1_i1 A4D1B5 GSAP_HUMAN 2.00E-09 GO:0005794; GO:0001540; GO:0034205; GO:0030162; GO:0005802 Golgi apparatus; beta-amyloid binding; beta-amyloid formation; regulation of proteolysis; trans-Golgi network IPR028010; IPR026172; Gamma-secretase-activating protein (GSAP) (Protein pigeon homolog) [Cleaved into: Gamma-secretase-activating protein 16 kDa C-terminal form (GSAP-16K)] GSAP PION Homo sapiens (Human) TR37860_c5_g2_i2 Q24118 PIGE_DROME 7.00E-11 IPR028010; IPR026172; Protein pigeon (Protein linotte) pigeon lio CG10739 Drosophila melanogaster (Fruit fly) TR37861_c0_g1_i1 Q24157 BRN_DROME 2.00E-28 GO:0000139; GO:0005795; GO:0007219; GO:0046981; GO:0007298; GO:0005576; GO:0047915; GO:0007293; GO:0006688; GO:0008314; GO:0016021; GO:0042248; GO:0001744; GO:0007299; GO:0006486 "Golgi membrane; Golgi stack; Notch signaling pathway; beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity; border follicle cell migration; extracellular region; ganglioside galactosyltransferase activity; germarium-derived egg chamber formation; glycosphingolipid biosynthetic process; gurken receptor signaling pathway; integral to membrane; maintenance of polarity of follicular epithelium; optic lobe placode formation; ovarian follicle cell-cell adhesion; protein glycosylation" IPR002659; "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) TR37861_c0_g1_i2 Q1RLK6 B3GN4_MOUSE 9.00E-18 GO:0000139; GO:0008378; GO:0016021; GO:0006486 Golgi membrane; galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 (BGnT-4) (Beta-1,3-Gn-T4) (Beta-1,3-N-acetylglucosaminyltransferase 4) (Beta3Gn-T4) (EC 2.4.1.-)" B3gnt4 Mus musculus (Mouse) TR37861_c0_g1_i4 Q24157 BRN_DROME 3.00E-28 GO:0000139; GO:0005795; GO:0007219; GO:0046981; GO:0007298; GO:0005576; GO:0047915; GO:0007293; GO:0006688; GO:0008314; GO:0016021; GO:0042248; GO:0001744; GO:0007299; GO:0006486 "Golgi membrane; Golgi stack; Notch signaling pathway; beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity; border follicle cell migration; extracellular region; ganglioside galactosyltransferase activity; germarium-derived egg chamber formation; glycosphingolipid biosynthetic process; gurken receptor signaling pathway; integral to membrane; maintenance of polarity of follicular epithelium; optic lobe placode formation; ovarian follicle cell-cell adhesion; protein glycosylation" IPR002659; "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) TR37861_c0_g1_i7 Q8NFL0 B3GN7_HUMAN 1.00E-19 GO:0000139; GO:0016266; GO:0008378; GO:0016021; GO:0018146; GO:0043687 Golgi membrane; O-glycan processing; galactosyltransferase activity; integral to membrane; keratan sulfate biosynthetic process; post-translational protein modification IPR002659; Protein modification; protein glycosylation. "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (BGnT-7) (Beta-1,3-Gn-T7) (Beta-1,3-N-acetylglucosaminyltransferase 7) (Beta3Gn-T7) (EC 2.4.1.-)" B3GNT7 Homo sapiens (Human) TR37862_c4_g3_i1 Q95J75 MFTC_MACFA 1.00E-06 GO:0016021; GO:0005743; GO:0006839 integral to membrane; mitochondrial inner membrane; mitochondrial transport IPR002030; IPR018108; IPR023395; Mitochondrial folate transporter/carrier (Solute carrier family 25 member 32) SLC25A32 MFTC QmoA-10785 QtrA-13024 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR37868_c1_g1_i2 Q01887 RYK_MOUSE 1.00E-152 GO:0005524; GO:0016055; GO:0042813; GO:0071679; GO:0022038; GO:0005737; GO:0016021; GO:0050919; GO:0048843; GO:0005634; GO:0005886; GO:0043410; GO:0004672; GO:0048705 ATP binding; Wnt receptor signaling pathway; Wnt-activated receptor activity; commissural neuron axon guidance; corpus callosum development; cytoplasm; integral to membrane; negative chemotaxis; negative regulation of axon extension involved in axon guidance; nucleus; plasma membrane; positive regulation of MAPK cascade; protein kinase activity; skeletal system morphogenesis IPR011009; IPR000719; IPR001245; IPR008266; IPR020635; IPR003306; Tyrosine-protein kinase RYK (EC 2.7.10.1) (Kinase VIK) (Met-related kinase) (NYK-R) Ryk Mrk Mus musculus (Mouse) TR37868_c1_g1_i3 O04534 LRK51_ARATH 6.00E-09 GO:0005524; GO:0030246; GO:0016021; GO:0005886; GO:0004674 ATP binding; carbohydrate binding; integral to membrane; plasma membrane; protein serine/threonine kinase activity IPR008985; IPR013320; IPR011009; IPR001220; IPR000719; IPR017441; IPR008271; Putative L-type lectin-domain containing receptor kinase V.1 (Arabidopsis thaliana lectin-receptor kinase b2) (AthlecRK-b2) (LecRK-V.1) (EC 2.7.11.1) LECRK51 LECRKB2 At1g70110 F20P5.16 Arabidopsis thaliana (Mouse-ear cress) TR37868_c1_g1_i4 P34925 RYK_HUMAN 2.00E-153 GO:0005524; GO:0016055; GO:0042813; GO:0007411; GO:0071679; GO:0022038; GO:0005737; GO:0005887; GO:0050919; GO:0048843; GO:0005634; GO:0043410; GO:0048705; GO:0004714 ATP binding; Wnt receptor signaling pathway; Wnt-activated receptor activity; axon guidance; commissural neuron axon guidance; corpus callosum development; cytoplasm; integral to plasma membrane; negative chemotaxis; negative regulation of axon extension involved in axon guidance; nucleus; positive regulation of MAPK cascade; skeletal system morphogenesis; transmembrane receptor protein tyrosine kinase activity IPR011009; IPR000719; IPR001245; IPR008266; IPR020635; IPR003306; Tyrosine-protein kinase RYK (EC 2.7.10.1) RYK JTK5A Homo sapiens (Human) TR37870_c0_g1_i2 A1Z3X3 GET4_ORYLA 2.00E-94 GO:0071818; GO:0071816; GO:0006810 BAT3 complex; tail-anchored membrane protein insertion into ER membrane; transport IPR007317; Golgi to ER traffic protein 4 homolog (Conserved edge expressed protein) get4 cee Oryzias latipes (Medaka fish) (Japanese ricefish) TR37870_c0_g1_i3 B5KFI0 GET4_TAEGU 2.00E-78 GO:0071818; GO:0071816; GO:0006810 BAT3 complex; tail-anchored membrane protein insertion into ER membrane; transport IPR007317; Golgi to ER traffic protein 4 homolog GET4 Taeniopygia guttata (Zebra finch) (Poephila guttata) TR37871_c5_g1_i2 Q09575 YRD6_CAEEL 1.00E-68 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR37871_c5_g1_i3 P20825 POL2_DROME 7.00E-12 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR37871_c6_g1_i1 Q09575 YRD6_CAEEL 2.00E-31 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR37872_c1_g1_i2 Q9Y6T7 DGKB_HUMAN 3.00E-06 GO:0005524; GO:0003951; GO:0005509; GO:0005737; GO:0004143; GO:0035556; GO:0005886; GO:0030168; GO:0007205 ATP binding; NAD+ kinase activity; calcium ion binding; cytoplasm; diacylglycerol kinase activity; intracellular signal transduction; plasma membrane; platelet activation; protein kinase C-activating G-protein coupled receptor signaling pathway IPR016064; IPR000756; IPR001206; IPR011992; IPR018247; IPR002048; IPR002219; Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta) DGKB DAGK2 KIAA0718 Homo sapiens (Human) TR37872_c1_g1_i3 P63100 CANB1_RAT 2.00E-85 GO:0005509; GO:0005829; GO:0004721; GO:0006470 calcium ion binding; cytosol; phosphoprotein phosphatase activity; protein dephosphorylation IPR011992; IPR018247; IPR002048; Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1) Ppp3r1 Cna2 Cnb Rattus norvegicus (Rat) TR37872_c3_g1_i1 Q8MIH6 RECO_CANFA 4.00E-07 GO:0005509; GO:0050896; GO:0007601 calcium ion binding; response to stimulus; visual perception IPR011992; IPR018247; IPR002048; IPR001125; Recoverin RCVRN RCV1 Canis familiaris (Dog) (Canis lupus familiaris) TR37877_c6_g3_i1 A2AX52 CO6A4_MOUSE 9.00E-32 GO:0007155; GO:0005581; GO:0005576; GO:0043234; GO:0070208 cell adhesion; collagen; extracellular region; protein complex; protein heterotrimerization IPR008160; IPR002035; Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) TR37877_c8_g2_i1 P13944 COCA1_CHICK 2.00E-25 GO:0007155; GO:0005581 cell adhesion; collagen IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain (Fibrochimerin) COL12A1 Gallus gallus (Chicken) TR37878_c6_g2_i8 P42292 CD166_CHICK 2.00E-06 GO:0007155; GO:0016021; GO:0005886 cell adhesion; integral to membrane; plasma membrane IPR013162; IPR007110; IPR013783; IPR003599; IPR013106; CD166 antigen (Activated leukocyte cell adhesion molecule) (BEN glycoprotein) (Protein DM-GRASP) (Protein JC7) (SC1 glycoprotein) (CD antigen CD166) ALCAM Gallus gallus (Chicken) TR37881_c0_g3_i13 Q5RC80 RBM39_PONAB 6.00E-178 GO:0003723; GO:0008380; GO:0006397; GO:0016607; GO:0000166; GO:0006355; GO:0006351 "RNA binding; RNA splicing; mRNA processing; nuclear speck; nucleotide binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006509; IPR012677; IPR000504; RNA-binding protein 39 (RNA-binding motif protein 39) RBM39 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37881_c0_g3_i6 Q7ZX83 HNDLA_XENLA 5.00E-14 GO:0003677; GO:0003723; GO:0005737; GO:0000166; GO:0005634; GO:0006355; GO:0006351 "DNA binding; RNA binding; cytoplasm; nucleotide binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein D-like-A (hnRNP D-like A) (hnRNP DL-A) hnrnpdl-a hnrpdl-a Xenopus laevis (African clawed frog) TR37881_c0_g3_i7 Q5RC80 RBM39_PONAB 3.00E-178 GO:0003723; GO:0008380; GO:0006397; GO:0016607; GO:0000166; GO:0006355; GO:0006351 "RNA binding; RNA splicing; mRNA processing; nuclear speck; nucleotide binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006509; IPR012677; IPR000504; RNA-binding protein 39 (RNA-binding motif protein 39) RBM39 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37882_c0_g2_i1 Q90X64 VNG2A_XENLA 6.00E-32 GO:0060071; GO:0060027; GO:0001736; GO:0016021; GO:0001843; GO:0005886; GO:0045813 "Wnt receptor signaling pathway, planar cell polarity pathway; convergent extension involved in gastrulation; establishment of planar polarity; integral to membrane; neural tube closure; plasma membrane; positive regulation of Wnt receptor signaling pathway, calcium modulating pathway" IPR009539; Vang-like protein 2-A (Protein strabismus-A) (Van Gogh-like protein 2-A) (Xstrabismus-A) (Xstbm-A) vangl2-a stbm-a Xenopus laevis (African clawed frog) TR37884_c0_g1_i2 Q8R1C6 MET22_MOUSE 1.00E-32 GO:0008168; GO:0005634 methyltransferase activity; nucleus IPR019410; Methyltransferase-like protein 22 (EC 2.1.1.-) Mettl22 Mus musculus (Mouse) TR37884_c0_g1_i3 Q8CDZ2 YM009_MOUSE 6.00E-09 GO:0008168 methyltransferase activity IPR019410; Protein-lysine methyltransferase METTL21E (EC 2.1.1.-) (Methyltransferase-like protein 21E) Mettl21e Mus musculus (Mouse) TR37886_c0_g1_i1 Q96T60 PNKP_HUMAN 1.00E-141 GO:0005524; GO:0046404; GO:0042769; GO:0006261; GO:0003684; GO:0003690; GO:0004519; GO:0005730; GO:0019201; GO:0000718; GO:0046403; GO:0006979; GO:0009314 P18887; Q13426 "ATP binding; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; DNA damage response, detection of DNA damage; DNA-dependent DNA replication; damaged DNA binding; double-stranded DNA binding; endonuclease activity; nucleolus; nucleotide kinase activity; nucleotide-excision repair, DNA damage removal; polynucleotide 3'-phosphatase activity; response to oxidative stress; response to radiation" IPR000253; IPR023214; IPR006549; IPR027417; IPR013954; IPR006550; IPR006551; IPR008984; Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] PNKP Homo sapiens (Human) TR37886_c0_g1_i2 Q96T60 PNKP_HUMAN 1.00E-141 GO:0005524; GO:0046404; GO:0042769; GO:0006261; GO:0003684; GO:0003690; GO:0004519; GO:0005730; GO:0019201; GO:0000718; GO:0046403; GO:0006979; GO:0009314 P18887; Q13426 "ATP binding; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; DNA damage response, detection of DNA damage; DNA-dependent DNA replication; damaged DNA binding; double-stranded DNA binding; endonuclease activity; nucleolus; nucleotide kinase activity; nucleotide-excision repair, DNA damage removal; polynucleotide 3'-phosphatase activity; response to oxidative stress; response to radiation" IPR000253; IPR023214; IPR006549; IPR027417; IPR013954; IPR006550; IPR006551; IPR008984; Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] PNKP Homo sapiens (Human) TR37886_c0_g1_i4 P61801 APTX_XENTR 5.00E-19 GO:0003677; GO:0006281; GO:0016787; GO:0046872; GO:0005730; GO:0005654 DNA binding; DNA repair; hydrolase activity; metal ion binding; nucleolus; nucleoplasm IPR000253; IPR019808; IPR001310; IPR011146; IPR008984; IPR015880; Aprataxin (EC 3.-.-.-) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) aptx TEgg082k23.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37888_c0_g1_i2 Q8JZN5 ACAD9_MOUSE 0 GO:0003995; GO:0030425; GO:0050660; GO:0005739; GO:0005634 acyl-CoA dehydrogenase activity; dendrite; flavin adenine dinucleotide binding; mitochondrion; nucleus IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; "Acyl-CoA dehydrogenase family member 9, mitochondrial (ACAD-9) (EC 1.3.99.-)" Acad9 Mus musculus (Mouse) TR37889_c1_g1_i1 P46825 KLC_LOLPE 0 GO:0005737; GO:0005871; GO:0005874; GO:0003777 cytoplasm; kinesin complex; microtubule; microtubule motor activity IPR002151; IPR015792; IPR015390; IPR013026; IPR011990; IPR001440; IPR019734; Kinesin light chain (KLC) Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR37889_c1_g1_i2 Q05090 KLC_STRPU 0 GO:0005737; GO:0005871; GO:0005874; GO:0003777 cytoplasm; kinesin complex; microtubule; microtubule motor activity IPR002151; IPR015792; IPR015390; IPR013026; IPR011990; IPR001440; IPR019734; Kinesin light chain (KLC) Strongylocentrotus purpuratus (Purple sea urchin) TR37889_c1_g1_i3 Q6AZT7 NPHP3_XENLA 2.00E-25 GO:0016055; GO:0060271; GO:0060027; GO:0090090; GO:0072372; GO:2000095 "Wnt receptor signaling pathway; cilium morphogenesis; convergent extension involved in gastrulation; negative regulation of canonical Wnt receptor signaling pathway; primary cilium; regulation of Wnt receptor signaling pathway, planar cell polarity pathway" IPR027417; IPR013026; IPR011990; IPR019734; Nephrocystin-3 nphp3 Xenopus laevis (African clawed frog) TR37889_c1_g1_i4 Q05090 KLC_STRPU 0 GO:0005737; GO:0005871; GO:0005874; GO:0003777 cytoplasm; kinesin complex; microtubule; microtubule motor activity IPR002151; IPR015792; IPR015390; IPR013026; IPR011990; IPR001440; IPR019734; Kinesin light chain (KLC) Strongylocentrotus purpuratus (Purple sea urchin) TR37889_c1_g1_i6 P46825 KLC_LOLPE 0 GO:0005737; GO:0005871; GO:0005874; GO:0003777 cytoplasm; kinesin complex; microtubule; microtubule motor activity IPR002151; IPR015792; IPR015390; IPR013026; IPR011990; IPR001440; IPR019734; Kinesin light chain (KLC) Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR37889_c1_g1_i8 P46825 KLC_LOLPE 2.00E-95 GO:0005737; GO:0005871; GO:0005874; GO:0003777 cytoplasm; kinesin complex; microtubule; microtubule motor activity IPR002151; IPR015792; IPR015390; IPR013026; IPR011990; IPR001440; IPR019734; Kinesin light chain (KLC) Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR37891_c3_g1_i1 O15182 CETN3_HUMAN 4.00E-83 GO:0005509; GO:0051301; GO:0005814; GO:0007098; GO:0045111; GO:0005932; GO:0007067; GO:0032391 calcium ion binding; cell division; centriole; centrosome cycle; intermediate filament cytoskeleton; microtubule basal body; mitosis; photoreceptor connecting cilium IPR011992; IPR018247; IPR002048; Centrin-3 CETN3 CEN3 Homo sapiens (Human) TR37891_c3_g1_i2 O74435 CDC31_SCHPO 2.00E-57 GO:0005509; GO:0051301; GO:0034613; GO:0005829; GO:0005825; GO:0007067; GO:0007052; GO:0044732; GO:0005634; GO:0007096; GO:0033047; GO:0030474; GO:0005198 calcium ion binding; cell division; cellular protein localization; cytosol; half bridge of spindle pole body; mitosis; mitotic spindle organization; mitotic spindle pole body; nucleus; regulation of exit from mitosis; regulation of mitotic sister chromatid segregation; spindle pole body duplication; structural molecule activity IPR011992; IPR018247; IPR002048; Cell division control protein 31 cdc31 SPCC1682.04 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR37893_c0_g1_i1 Q5R4J5 SYT1_PONAB 7.00E-14 GO:0030054; GO:0042584; GO:0016021; GO:0046872; GO:0030672; GO:0005215 cell junction; chromaffin granule membrane; integral to membrane; metal ion binding; synaptic vesicle membrane; transporter activity IPR000008; IPR001565; IPR015428; Synaptotagmin-1 (Synaptotagmin I) (SytI) SYT1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37893_c0_g2_i1 Q920N7 SYT12_MOUSE 3.00E-11 GO:0030054; GO:0016021; GO:0030672; GO:0005215 cell junction; integral to membrane; synaptic vesicle membrane; transporter activity IPR000008; IPR001565; Synaptotagmin-12 (Synaptotagmin XII) (SytXII) Syt12 Mus musculus (Mouse) TR37893_c2_g1_i1 O08625 SYT10_RAT 3.00E-08 GO:0030054; GO:0016021; GO:0046872; GO:0050803; GO:0030672; GO:0005215 cell junction; integral to membrane; metal ion binding; regulation of synapse structure and activity; synaptic vesicle membrane; transporter activity IPR000008; IPR001565; Synaptotagmin-10 (Synaptotagmin X) (SytX) Syt10 Rattus norvegicus (Rat) TR37895_c1_g1_i2 Q1LZE1 KCMF1_BOVIN 4.00E-94 GO:0016874; GO:0008270 ligase activity; zinc ion binding IPR008598; IPR007087; IPR015880; IPR000433; E3 ubiquitin-protein ligase KCMF1 (EC 6.3.2.-) KCMF1 Bos taurus (Bovine) TR37895_c1_g2_i1 Q7T321 KCMF1_DANRE 2.00E-20 GO:0016874; GO:0008270 ligase activity; zinc ion binding IPR008598; IPR007087; IPR015880; IPR000433; E3 ubiquitin-protein ligase KCMF1 (EC 6.3.2.-) kcmf1 si:ch211-220b11.7 Danio rerio (Zebrafish) (Brachydanio rerio) TR37897_c1_g3_i1 Q86Y56 HEAT2_HUMAN 2.00E-35 GO:0005737 cytoplasm IPR011989; IPR016024; IPR000357; IPR021133; HEAT repeat-containing protein 2 HEATR2 Homo sapiens (Human) TR37897_c2_g1_i1 Q86Y56 HEAT2_HUMAN 1.00E-145 GO:0005737 cytoplasm IPR011989; IPR016024; IPR000357; IPR021133; HEAT repeat-containing protein 2 HEATR2 Homo sapiens (Human) TR37898_c3_g1_i1 Q8CIV2 MBRL_MOUSE 1.00E-139 GO:0016021 integral to membrane IPR019144; Membralin (Transmembrane protein 259) Tmem259 ORF61 Mus musculus (Mouse) TR37898_c3_g1_i4 Q4ZIN3 MBRL_HUMAN 2.00E-139 GO:0005737; GO:0016021 cytoplasm; integral to membrane IPR019144; Membralin (Transmembrane protein 259) TMEM259 C19orf6 Homo sapiens (Human) TR37900_c0_g1_i3 A1T0M9 YIDC_PSYIN 5.00E-08 GO:0016021; GO:0005886; GO:0051205; GO:0015031 integral to membrane; plasma membrane; protein insertion into membrane; protein transport IPR019998; IPR028055; IPR028053; IPR001708; Membrane protein insertase YidC (Foldase YidC) (Membrane integrase YidC) (Membrane protein YidC) yidC Ping_3611 Psychromonas ingrahamii (strain 37) TR37900_c0_g1_i4 Q8BGA9 OXA1L_MOUSE 1.00E-51 GO:0016021; GO:0005743; GO:0097031; GO:0097177; GO:0042803; GO:0051205; GO:0051262 integral to membrane; mitochondrial inner membrane; mitochondrial respiratory chain complex I biogenesis; mitochondrial ribosome binding; protein homodimerization activity; protein insertion into membrane; protein tetramerization IPR028055; IPR001708; Mitochondrial inner membrane protein OXA1L (Oxidase assembly 1-like protein) (OXA1-like protein) Oxa1l Mus musculus (Mouse) TR37900_c0_g2_i1 Q8BGA9 OXA1L_MOUSE 3.00E-24 GO:0016021; GO:0005743; GO:0097031; GO:0097177; GO:0042803; GO:0051205; GO:0051262 integral to membrane; mitochondrial inner membrane; mitochondrial respiratory chain complex I biogenesis; mitochondrial ribosome binding; protein homodimerization activity; protein insertion into membrane; protein tetramerization IPR028055; IPR001708; Mitochondrial inner membrane protein OXA1L (Oxidase assembly 1-like protein) (OXA1-like protein) Oxa1l Mus musculus (Mouse) TR37902_c0_g1_i1 Q58D79 RPH3L_BOVIN 2.00E-71 GO:0006887; GO:0006886; GO:0046872; GO:0030658 exocytosis; intracellular protein transport; metal ion binding; transport vesicle membrane IPR017455; IPR010911; IPR011011; IPR013083; Rab effector Noc2 (No C2 domains protein) (Rabphilin-3A-like protein) RPH3AL NOC2 Bos taurus (Bovine) TR37902_c0_g2_i1 Q14184 DOC2B_HUMAN 7.00E-75 GO:0048791; GO:0005544; GO:0005737; GO:0015630; GO:0005886; GO:0045956; GO:0032024; GO:0031340; GO:0008104; GO:0008021; GO:0005215 calcium ion-dependent exocytosis of neurotransmitter; calcium-dependent phospholipid binding; cytoplasm; microtubule cytoskeleton; plasma membrane; positive regulation of calcium ion-dependent exocytosis; positive regulation of insulin secretion; positive regulation of vesicle fusion; protein localization; synaptic vesicle; transporter activity IPR000008; IPR014638; IPR001565; Double C2-like domain-containing protein beta (Doc2-beta) DOC2B DOC2BL Homo sapiens (Human) TR37902_c0_g2_i2 Q9Y6V0 PCLO_HUMAN 7.00E-20 GO:0019933; GO:0005509; GO:0005544; GO:0030054; GO:0005856; GO:0007010; GO:0030073; GO:0016020; GO:0005522; GO:0017157; GO:0045202; GO:0008021; GO:0016079; GO:0005215 cAMP-mediated signaling; calcium ion binding; calcium-dependent phospholipid binding; cell junction; cytoskeleton; cytoskeleton organization; insulin secretion; membrane; profilin binding; regulation of exocytosis; synapse; synaptic vesicle; synaptic vesicle exocytosis; transporter activity IPR000008; IPR001565; IPR011011; IPR008899; IPR013083; Protein piccolo (Aczonin) PCLO ACZ KIAA0559 Homo sapiens (Human) TR37902_c1_g3_i1 Q9W391 KPBA_DROME 0 GO:0005977; GO:0004553; GO:0005886 "glycogen metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; plasma membrane" IPR008928; IPR012341; IPR011613; IPR008734; Glycan biosynthesis; glycogen metabolism. Probable phosphorylase b kinase regulatory subunit alpha (Phosphorylase kinase subunit alpha) CG7766 Drosophila melanogaster (Fruit fly) TR37902_c1_g3_i2 P46019 KPB2_HUMAN 0 GO:0005829; GO:0006006; GO:0005980; GO:0004553; GO:0004689; GO:0005964; GO:0005886; GO:0044281 "cytosol; glucose metabolic process; glycogen catabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; phosphorylase kinase activity; phosphorylase kinase complex; plasma membrane; small molecule metabolic process" IPR008928; IPR012341; IPR011613; IPR008734; Glycan biosynthesis; glycogen metabolism. "Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit)" PHKA2 PHKLA PYK Homo sapiens (Human) TR37903_c1_g1_i4 O43657 TSN6_HUMAN 3.00E-07 GO:0016021; GO:0043123; GO:0004871 integral to membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-6 (Tspan-6) (A15 homolog) (Putative NF-kappa-B-activating protein 321) (T245 protein) (Tetraspanin TM4-D) (Transmembrane 4 superfamily member 6) TSPAN6 TM4SF6 UNQ767/PRO1560 Homo sapiens (Human) TR37906_c1_g1_i1 P21912 DHSB_HUMAN 9.00E-144 GO:0051537; GO:0051538; GO:0051539; GO:0009055; GO:0046872; GO:0005749; GO:0022904; GO:0044281; GO:0008177; GO:0006105; GO:0006099; GO:0048039 P31040 "2 iron, 2 sulfur cluster binding; 3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; electron carrier activity; metal ion binding; mitochondrial respiratory chain complex II; respiratory electron transport chain; small molecule metabolic process; succinate dehydrogenase (ubiquinone) activity; succinate metabolic process; tricarboxylic acid cycle; ubiquinone binding" IPR001041; IPR006058; IPR017896; IPR017900; IPR012675; IPR009051; IPR004489; IPR025192; Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip)" SDHB SDH SDH1 Homo sapiens (Human) TR37907_c1_g1_i1 O93430 GLRA1_DANRE 6.00E-110 GO:0030054; GO:0034707; GO:0016934; GO:0016594; GO:0005887; GO:0045211; GO:0022824 cell junction; chloride channel complex; extracellular-glycine-gated chloride channel activity; glycine binding; integral to plasma membrane; postsynaptic membrane; transmitter-gated ion channel activity IPR006028; IPR008127; IPR008128; IPR006202; IPR006201; IPR006029; IPR018000; Glycine receptor subunit alphaZ1 glra1 Danio rerio (Zebrafish) (Brachydanio rerio) TR37907_c1_g1_i4 P24524 GLRA3_RAT 3.00E-107 GO:0030054; GO:0034707; GO:0016934; GO:0016594; GO:0005887; GO:0045211; GO:0022824 cell junction; chloride channel complex; extracellular-glycine-gated chloride channel activity; glycine binding; integral to plasma membrane; postsynaptic membrane; transmitter-gated ion channel activity IPR006028; IPR008127; IPR008130; IPR006202; IPR006201; IPR006029; IPR018000; Glycine receptor subunit alpha-3 Glra3 Rattus norvegicus (Rat) TR37909_c1_g1_i1 Q6P2X9 MOT12_XENTR 2.00E-14 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37909_c1_g1_i2 Q5ZJU0 MOT9_CHICK 9.00E-09 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 MCT9 RCJMB04_15m4 Gallus gallus (Chicken) TR37909_c1_g1_i5 Q8K1P8 MOT8_RAT 8.00E-06 GO:0016021; GO:0005886; GO:0015293; GO:0015349 integral to membrane; plasma membrane; symporter activity; thyroid hormone transmembrane transporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 8 (MCT 8) (Solute carrier family 16 member 2) Slc16a2 Mct8 Rattus norvegicus (Rat) TR37909_c1_g1_i6 Q6P2X9 MOT12_XENTR 1.00E-19 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR37909_c1_g1_i7 Q7TM99 MOT9_MOUSE 2.00E-17 GO:0016021; GO:0005886; GO:0015293; GO:0046415 integral to membrane; plasma membrane; symporter activity; urate metabolic process IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) Slc16a9 Mct9 Mus musculus (Mouse) TR37912_c0_g1_i1 Q3T001 H17B6_BOVIN 3.00E-34 GO:0005789; GO:0004303; GO:0004745; GO:0008202; GO:0047035 endoplasmic reticulum membrane; estradiol 17-beta-dehydrogenase activity; retinol dehydrogenase activity; steroid metabolic process; testosterone dehydrogenase (NAD+) activity IPR002198; IPR002347; IPR016040; IPR020904; 17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.239) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) HSD17B6 Bos taurus (Bovine) TR37912_c0_g1_i2 Q9R092 H17B6_MOUSE 1.00E-33 GO:0031901; GO:0005783; GO:0004303; GO:0004745; GO:0008202; GO:0047035 early endosome membrane; endoplasmic reticulum; estradiol 17-beta-dehydrogenase activity; retinol dehydrogenase activity; steroid metabolic process; testosterone dehydrogenase (NAD+) activity IPR002198; IPR002347; IPR016040; IPR020904; 17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.239) (EC 1.1.1.62) (17-beta-HSD9) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) Hsd17b6 Gm182 Hsd17b9 Rdh8 Mus musculus (Mouse) TR37912_c0_g2_i1 Q3T001 H17B6_BOVIN 8.00E-39 GO:0005789; GO:0004303; GO:0004745; GO:0008202; GO:0047035 endoplasmic reticulum membrane; estradiol 17-beta-dehydrogenase activity; retinol dehydrogenase activity; steroid metabolic process; testosterone dehydrogenase (NAD+) activity IPR002198; IPR002347; IPR016040; IPR020904; 17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.239) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) HSD17B6 Bos taurus (Bovine) TR37912_c0_g2_i2 Q99J47 DRS7B_MOUSE 4.00E-08 GO:0016021; GO:0016491; GO:0005778 integral to membrane; oxidoreductase activity; peroxisomal membrane IPR002198; IPR002347; IPR016040; IPR020904; Dehydrogenase/reductase SDR family member 7B (EC 1.1.-.-) Dhrs7b Mus musculus (Mouse) TR37912_c0_g2_i3 O14756 H17B6_HUMAN 2.00E-35 GO:0006702; GO:0006710; GO:0031901; GO:0009055; GO:0005783; GO:0004303; GO:0005622; GO:0016491; GO:0004745; GO:0047035 androgen biosynthetic process; androgen catabolic process; early endosome membrane; electron carrier activity; endoplasmic reticulum; estradiol 17-beta-dehydrogenase activity; intracellular; oxidoreductase activity; retinol dehydrogenase activity; testosterone dehydrogenase (NAD+) activity IPR002198; IPR002347; IPR016040; IPR020904; 17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.239) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) HSD17B6 RODH Homo sapiens (Human) TR37913_c0_g1_i1 Q9NVX2 NLE1_HUMAN 3.00E-122 GO:0007219; GO:0001826; GO:0005730 Notch signaling pathway; inner cell mass cell differentiation; nucleolus IPR020472; IPR001632; IPR012972; IPR015943; IPR001680; IPR019775; IPR017986; Notchless protein homolog 1 NLE1 HUSSY-07 Homo sapiens (Human) TR37913_c0_g1_i2 Q54KL5 WDR5_DICDI 1.00E-24 GO:0051568; GO:0042393; GO:0035097 histone H3-K4 methylation; histone binding; histone methyltransferase complex IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 5 homolog wdr5 DDB_G0287273 Dictyostelium discoideum (Slime mold) TR37913_c0_g2_i1 P69104 GBLP_TRYBR 7.00E-16 IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Guanine nucleotide-binding protein subunit beta-like protein (Activated protein kinase C receptor homolog) (Track) Trypanosoma brucei rhodesiense TR37915_c0_g2_i1 Q6NXA9 UBXN1_DANRE 7.00E-10 GO:0071796; GO:0005737; GO:0032435; GO:0031397 K6-linked polyubiquitin binding; cytoplasm; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein ubiquitination IPR009060; IPR015940; IPR000449; IPR001012; UBX domain-containing protein 1 (SAPK substrate protein 1) ubxn1 saks1 zgc:77531 Danio rerio (Zebrafish) (Brachydanio rerio) TR37917_c0_g1_i1 P17844 DDX5_HUMAN 2.00E-101 GO:0005524; GO:0004004; GO:0003724; GO:0050681; GO:0071013; GO:0016049; GO:0007623; GO:0030331; GO:0001701; GO:0072332; GO:0000398; GO:0000122; GO:0005730; GO:0043517; GO:0033148; GO:0045944; GO:0036002; GO:0000381; GO:0060765; GO:0045667; GO:2001014; GO:0045069; GO:0003713; GO:0006351 Q12873; P45481; Q09472; P03372; P22087; Q13547; O95983; P10085; O94916; P24928; Q08775-3; P04637; P04637-1; P04637-7 "ATP binding; ATP-dependent RNA helicase activity; RNA helicase activity; androgen receptor binding; catalytic step 2 spliceosome; cell growth; circadian rhythm; estrogen receptor binding; in utero embryonic development; intrinsic apoptotic signaling pathway by p53 class mediator; mRNA splicing, via spliceosome; negative regulation of transcription from RNA polymerase II promoter; nucleolus; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; pre-mRNA binding; regulation of alternative mRNA splicing, via spliceosome; regulation of androgen receptor signaling pathway; regulation of osteoblast differentiation; regulation of skeletal muscle cell differentiation; regulation of viral genome replication; transcription coactivator activity; transcription, DNA-dependent" IPR011545; IPR014001; IPR001650; IPR027417; IPR012587; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) DDX5 G17P1 HELR HLR1 Homo sapiens (Human) TR37917_c0_g2_i1 Q8H136 RH14_ARATH 7.00E-28 GO:0005524; GO:0004004; GO:0003723; GO:0000184; GO:0005634; GO:0006364 "ATP binding; ATP-dependent RNA helicase activity; RNA binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus; rRNA processing" IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; IPR001202; DEAD-box ATP-dependent RNA helicase 14 (EC 3.6.4.13) RH14 DRH1 At3g01540 F4P13.9 Arabidopsis thaliana (Mouse-ear cress) TR37917_c0_g2_i2 Q553B1 DDX46_DICDI 7.00E-14 GO:0005524; GO:0004004; GO:0000375; GO:0006397; GO:0003676; GO:0005681 "ATP binding; ATP-dependent RNA helicase activity; RNA splicing, via transesterification reactions; mRNA processing; nucleic acid binding; spliceosomal complex" IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase ddx46 (EC 3.6.4.13) (ATP-dependent RNA helicase helB1) (DEAD box protein 46) helB1 ddx46 hel2A DDB_G0275443 Dictyostelium discoideum (Slime mold) TR37918_c2_g1_i2 Q9HB90 RRAGC_HUMAN 1.00E-125 GO:0019003; GO:0005525; GO:0003924; GO:0008380; GO:0006915; GO:0016049; GO:0034613; GO:0071230; GO:0005764; GO:0000287; GO:0005634; GO:0007264; GO:0006351 Q7L523; Q5VZM2 "GDP binding; GTP binding; GTPase activity; RNA splicing; apoptotic process; cell growth; cellular protein localization; cellular response to amino acid stimulus; lysosome; magnesium ion binding; nucleus; small GTPase mediated signal transduction; transcription, DNA-dependent" IPR006762; IPR027417; Ras-related GTP-binding protein C (Rag C) (RagC) (GTPase-interacting protein 2) (TIB929) RRAGC Homo sapiens (Human) TR37919_c4_g1_i1 A8E7G4 FA45A_DANRE 2.00E-119 Protein FAM45A (Protein FAM45) fam45a fam45 si:ch211-117n7.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR37921_c0_g1_i7 Q08731 LIT2_MOUSE 6.00E-06 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Lithostathine-2 (Islet of Langerhans regenerating protein 2) (REG-2) (Pancreatic stone protein 2) (PSP) (Pancreatic thread protein 2) (PTP) Reg2 Mus musculus (Mouse) TR37922_c1_g2_i1 Q11HH5 AMPA_MESSB 3.00E-27 GO:0004177; GO:0005737; GO:0030145; GO:0008235; GO:0006508 aminopeptidase activity; cytoplasm; manganese ion binding; metalloexopeptidase activity; proteolysis IPR011356; IPR000819; IPR023042; IPR008283; Probable cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase) (LAP) (EC 3.4.11.10) (Leucyl aminopeptidase) pepA Meso_1756 Mesorhizobium sp. (strain BNC1) TR37922_c1_g2_i3 Q27245 YH24_CAEEL 7.00E-138 GO:0004177; GO:0005737; GO:0030145; GO:0008235; GO:0006508 aminopeptidase activity; cytoplasm; manganese ion binding; metalloexopeptidase activity; proteolysis IPR011356; IPR000819; Putative aminopeptidase W07G4.4 (EC 3.4.11.-) W07G4.4 Caenorhabditis elegans TR37923_c1_g2_i1 P08548 LIN1_NYCCO 5.00E-16 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR37924_c7_g1_i1 Q96MW5 COG8_HUMAN 0 GO:0000139; GO:0017119; GO:0015031 Golgi membrane; Golgi transport complex; protein transport IPR007255; IPR016632; IPR016159; Conserved oligomeric Golgi complex subunit 8 (COG complex subunit 8) (Component of oligomeric Golgi complex 8) COG8 Homo sapiens (Human) TR37925_c0_g1_i2 P20735 GGT1_PIG 6.00E-130 GO:0003840; GO:0006536; GO:0006750; GO:0006751; GO:0036374; GO:0016021 gamma-glutamyltransferase activity; glutamate metabolic process; glutathione biosynthetic process; glutathione catabolic process; glutathione hydrolase activity; integral to membrane IPR000101; Sulfur metabolism; glutathione metabolism. Gamma-glutamyltranspeptidase 1 (GGT 1) (EC 2.3.2.2) (Gamma-glutamyltransferase 1) (Glutathione hydrolase 1) (EC 3.4.19.13) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Gamma-glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain] GGT1 GGT Sus scrofa (Pig) TR37925_c0_g1_i4 P20735 GGT1_PIG 8.00E-130 GO:0003840; GO:0006536; GO:0006750; GO:0006751; GO:0036374; GO:0016021 gamma-glutamyltransferase activity; glutamate metabolic process; glutathione biosynthetic process; glutathione catabolic process; glutathione hydrolase activity; integral to membrane IPR000101; Sulfur metabolism; glutathione metabolism. Gamma-glutamyltranspeptidase 1 (GGT 1) (EC 2.3.2.2) (Gamma-glutamyltransferase 1) (Glutathione hydrolase 1) (EC 3.4.19.13) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Gamma-glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain] GGT1 GGT Sus scrofa (Pig) TR37926_c0_g1_i1 Q6ZSM3 MOT12_HUMAN 2.00E-33 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) SLC16A12 MCT12 Homo sapiens (Human) TR37926_c0_g1_i5 Q6ZSM3 MOT12_HUMAN 2.00E-33 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) SLC16A12 MCT12 Homo sapiens (Human) TR37928_c0_g1_i1 Q52118 YMO3_ERWST 2.00E-16 IPR001646; Uncharacterized protein in mobD 3'region Erwinia stewartii TR37928_c0_g1_i3 Q7L273 KCTD9_HUMAN 2.00E-153 GO:0051260 protein homooligomerization IPR001646; IPR000210; IPR011333; IPR021789; IPR003131; BTB/POZ domain-containing protein KCTD9 KCTD9 Homo sapiens (Human) TR37928_c0_g1_i5 Q52118 YMO3_ERWST 2.00E-16 IPR001646; Uncharacterized protein in mobD 3'region Erwinia stewartii TR37928_c0_g1_i6 Q7L273 KCTD9_HUMAN 3.00E-154 GO:0051260 protein homooligomerization IPR001646; IPR000210; IPR011333; IPR021789; IPR003131; BTB/POZ domain-containing protein KCTD9 KCTD9 Homo sapiens (Human) TR37929_c3_g1_i1 Q6UB98 ANR12_HUMAN 3.00E-54 GO:0005737; GO:0005634 cytoplasm; nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) ANKRD12 ANCO2 KIAA0874 Homo sapiens (Human) TR37930_c0_g2_i4 Q9BXW7 CECR5_HUMAN 4.00E-52 GO:0005739 mitochondrion IPR023214; IPR006357; IPR006353; Cat eye syndrome critical region protein 5 CECR5 Homo sapiens (Human) TR37930_c0_g2_i9 Q9BXW7 CECR5_HUMAN 6.00E-86 GO:0005739 mitochondrion IPR023214; IPR006357; IPR006353; Cat eye syndrome critical region protein 5 CECR5 Homo sapiens (Human) TR37931_c2_g1_i1 P13595 NCAM1_MOUSE 3.00E-13 GO:0031225; GO:0030424; GO:0007166; GO:0009897; GO:0030426; GO:0008201; GO:0034109; GO:0016021; GO:0031175; GO:0043025; GO:0050850; GO:0001928 anchored to membrane; axon; cell surface receptor signaling pathway; external side of plasma membrane; growth cone; heparin binding; homotypic cell-cell adhesion; integral to membrane; neuron projection development; neuronal cell body; positive regulation of calcium-mediated signaling; regulation of exocyst assembly IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR009138; Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56) Ncam1 Ncam Mus musculus (Mouse) TR37935_c0_g1_i1 Q54ZN3 Y0004_DICDI 9.00E-08 GO:0005524; GO:0046872; GO:0005634; GO:0004674; GO:0004713; GO:0051726 ATP binding; metal ion binding; nucleus; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of cell cycle IPR011009; IPR000719; IPR017441; IPR008271; Probable protein kinase DDB_G0277539 (EC 2.7.11.1) DDB_G0277539 Dictyostelium discoideum (Slime mold) TR37935_c0_g1_i2 P48479 NIM1_NEUCR 2.00E-09 GO:0005524; GO:0051301; GO:0007067; GO:0005634; GO:0050921; GO:0004674 ATP binding; cell division; mitosis; nucleus; positive regulation of chemotaxis; protein serine/threonine kinase activity IPR011009; IPR000719; IPR002290; IPR008271; G2-specific protein kinase nim-1 (EC 2.7.11.1) nim-1 NCU03187 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR37935_c0_g1_i3 Q5R7G9 NUAK2_PONAB 4.00E-38 GO:0005524; GO:0030036; GO:0006915; GO:0042149; GO:0000287; GO:0043066; GO:0004674 ATP binding; actin cytoskeleton organization; apoptotic process; cellular response to glucose starvation; magnesium ion binding; negative regulation of apoptotic process; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; NUAK family SNF1-like kinase 2 (EC 2.7.11.1) NUAK2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37935_c0_g1_i5 Q55FT4 TSUA_DICDI 2.00E-30 GO:0005524; GO:0043327; GO:0043326; GO:0005881; GO:0030010; GO:0030837; GO:0004674; GO:0060176; GO:0031272 ATP binding; chemotaxis to cAMP; chemotaxis to folate; cytoplasmic microtubule; establishment of cell polarity; negative regulation of actin filament polymerization; protein serine/threonine kinase activity; regulation of aggregation involved in sorocarp development; regulation of pseudopodium assembly IPR011989; IPR016024; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Probable serine/threonine-protein kinase tsuA (EC 2.7.11.1) (Tsunami) tsuA DDB_G0267962 Dictyostelium discoideum (Slime mold) TR37935_c0_g1_i7 Q55FT4 TSUA_DICDI 4.00E-30 GO:0005524; GO:0043327; GO:0043326; GO:0005881; GO:0030010; GO:0030837; GO:0004674; GO:0060176; GO:0031272 ATP binding; chemotaxis to cAMP; chemotaxis to folate; cytoplasmic microtubule; establishment of cell polarity; negative regulation of actin filament polymerization; protein serine/threonine kinase activity; regulation of aggregation involved in sorocarp development; regulation of pseudopodium assembly IPR011989; IPR016024; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Probable serine/threonine-protein kinase tsuA (EC 2.7.11.1) (Tsunami) tsuA DDB_G0267962 Dictyostelium discoideum (Slime mold) TR37935_c0_g1_i9 Q55FJ6 Y8078_DICDI 6.00E-26 GO:0005524; GO:0004693 ATP binding; cyclin-dependent protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Probable serine/threonine-protein kinase DDB_G0268078 (EC 2.7.11.22) DDB_G0268078 Dictyostelium discoideum (Slime mold) TR37936_c2_g1_i1 Q5NC05 TTF2_MOUSE 2.00E-140 GO:0005524; GO:0008026; GO:0003677; GO:0006353; GO:0008380; GO:0005737; GO:0006397; GO:0006355; GO:0005681; GO:0008270 "ATP binding; ATP-dependent helicase activity; DNA binding; DNA-dependent transcription, termination; RNA splicing; cytoplasm; mRNA processing; regulation of transcription, DNA-dependent; spliceosomal complex; zinc ion binding" IPR002464; IPR014001; IPR001650; IPR027417; IPR000330; IPR010666; Transcription termination factor 2 (EC 3.6.4.-) (RNA polymerase II termination factor) (Transcription release factor 2) Ttf2 Mus musculus (Mouse) TR37937_c0_g1_i2 Q16566 KCC4_HUMAN 2.00E-128 GO:0005524; GO:0007202; GO:0004683; GO:0005829; GO:0007173; GO:0008543; GO:0006954; GO:0045087; GO:0007616; GO:0043011; GO:0007270; GO:0048011; GO:0006913; GO:0005730; GO:0005654; GO:0046827; GO:0045893; GO:0006468; GO:0033081; GO:0045670; GO:0007268 "ATP binding; activation of phospholipase C activity; calmodulin-dependent protein kinase activity; cytosol; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; inflammatory response; innate immune response; long-term memory; myeloid dendritic cell differentiation; neuron-neuron synaptic transmission; neurotrophin TRK receptor signaling pathway; nucleocytoplasmic transport; nucleolus; nucleoplasm; positive regulation of protein export from nucleus; positive regulation of transcription, DNA-dependent; protein phosphorylation; regulation of T cell differentiation in thymus; regulation of osteoclast differentiation; synaptic transmission" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) CAMK4 CAMK CAMK-GR CAMKIV Homo sapiens (Human) TR37937_c0_g1_i4 Q16566 KCC4_HUMAN 9.00E-128 GO:0005524; GO:0007202; GO:0004683; GO:0005829; GO:0007173; GO:0008543; GO:0006954; GO:0045087; GO:0007616; GO:0043011; GO:0007270; GO:0048011; GO:0006913; GO:0005730; GO:0005654; GO:0046827; GO:0045893; GO:0006468; GO:0033081; GO:0045670; GO:0007268 "ATP binding; activation of phospholipase C activity; calmodulin-dependent protein kinase activity; cytosol; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; inflammatory response; innate immune response; long-term memory; myeloid dendritic cell differentiation; neuron-neuron synaptic transmission; neurotrophin TRK receptor signaling pathway; nucleocytoplasmic transport; nucleolus; nucleoplasm; positive regulation of protein export from nucleus; positive regulation of transcription, DNA-dependent; protein phosphorylation; regulation of T cell differentiation in thymus; regulation of osteoclast differentiation; synaptic transmission" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) CAMK4 CAMK CAMK-GR CAMKIV Homo sapiens (Human) TR37938_c0_g1_i1 Q4R8B9 HORM1_MACFA 5.00E-77 GO:0001824; GO:0030154; GO:0005694; GO:0042138; GO:0051598; GO:0051177; GO:0005634; GO:0048477; GO:0060629; GO:0007283; GO:0007130 blastocyst development; cell differentiation; chromosome; meiotic DNA double-strand break formation; meiotic recombination checkpoint; meiotic sister chromatid cohesion; nucleus; oogenesis; regulation of homologous chromosome segregation; spermatogenesis; synaptonemal complex assembly IPR003511; HORMA domain-containing protein 1 HORMAD1 QtsA-11904 QtsA-12863 QtsA-16861 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR37939_c4_g1_i1 Q8VDB8 LRRC2_MOUSE 4.00E-07 IPR001611; IPR025875; IPR003591; Leucine-rich repeat-containing protein 2 Lrrc2 Mus musculus (Mouse) TR37939_c4_g1_i2 Q8AVS8 LRC59_XENLA 4.00E-65 GO:0005789; GO:0016021; GO:0005635 endoplasmic reticulum membrane; integral to membrane; nuclear envelope IPR001611; Leucine-rich repeat-containing protein 59 lrrc59 Xenopus laevis (African clawed frog) TR37939_c4_g1_i3 Q7KRY7 LAP4_DROME 7.00E-10 GO:0072002; GO:0007464; GO:0030714; GO:0016327; GO:0016323; GO:0060581; GO:0001708; GO:0000902; GO:0007391; GO:0045198; GO:0001737; GO:0016332; GO:0016336; GO:0005576; GO:0045169; GO:0005179; GO:0016328; GO:0050680; GO:0045571; GO:0000122; GO:0031594; GO:0042048; GO:0007318; GO:0045823; GO:0046425; GO:0008593; GO:0051726; GO:0030100; GO:0042058; GO:0050803; GO:0007608; GO:0005918; GO:0019991; GO:0048863; GO:0072089; GO:0005923; GO:0045186 Q4AB30 "Malpighian tubule development; R3/R4 cell fate commitment; anterior/posterior axis specification, follicular epithelium; apicolateral plasma membrane; basolateral plasma membrane; cell fate commitment involved in pattern specification; cell fate specification; cell morphogenesis; dorsal closure; establishment of epithelial cell apical/basal polarity; establishment of imaginal disc-derived wing hair orientation; establishment or maintenance of polarity of embryonic epithelium; establishment or maintenance of polarity of larval imaginal disc epithelium; extracellular region; fusome; hormone activity; lateral plasma membrane; negative regulation of epithelial cell proliferation; negative regulation of imaginal disc growth; negative regulation of transcription from RNA polymerase II promoter; neuromuscular junction; olfactory behavior; pole plasm protein localization; positive regulation of heart contraction; regulation of JAK-STAT cascade; regulation of Notch signaling pathway; regulation of cell cycle; regulation of endocytosis; regulation of epidermal growth factor receptor signaling pathway; regulation of synapse structure and activity; sensory perception of smell; septate junction; septate junction assembly; stem cell differentiation; stem cell proliferation; tight junction; zonula adherens assembly" IPR001611; IPR025875; IPR001478; Protein lap4 (Protein scribble) (Protein smell-impaired) scrib smi vart CG5462 Drosophila melanogaster (Fruit fly) TR37939_c4_g1_i6 Q8N9N7 LRC57_HUMAN 2.00E-08 IPR001611; IPR025875; IPR003591; Leucine-rich repeat-containing protein 57 LRRC57 Homo sapiens (Human) TR37939_c4_g1_i7 A8JAM0 CC135_CHLRE 7.00E-12 GO:0030154; GO:0001539; GO:0031514; GO:0007283 cell differentiation; ciliary or bacterial-type flagellar motility; motile cilium; spermatogenesis IPR015915; IPR001611; Coiled-coil domain-containing protein lobo homolog (Flagellar-associated protein 50) (Fragment) FAP50 CHLREDRAFT_177591 Chlamydomonas reinhardtii (Chlamydomonas smithii) TR37939_c4_g1_i8 Q8AVS8 LRC59_XENLA 1.00E-57 GO:0005789; GO:0016021; GO:0005635 endoplasmic reticulum membrane; integral to membrane; nuclear envelope IPR001611; Leucine-rich repeat-containing protein 59 lrrc59 Xenopus laevis (African clawed frog) TR37939_c4_g1_i9 Q922Q8 LRC59_MOUSE 2.00E-57 GO:0005789; GO:0016021; GO:0042645; GO:0005635 endoplasmic reticulum membrane; integral to membrane; mitochondrial nucleoid; nuclear envelope IPR001611; Leucine-rich repeat-containing protein 59 Lrrc59 Mus musculus (Mouse) TR37942_c2_g1_i1 A7MB11 TGFA1_BOVIN 4.00E-157 GO:0005737; GO:0006886; GO:0005083; GO:0016192 cytoplasm; intracellular protein transport; small GTPase regulator activity; vesicle-mediated transport IPR001180; IPR000547; IPR019452; IPR019453; Transforming growth factor-beta receptor-associated protein 1 (TGF-beta receptor-associated protein 1) (TRAP-1) (TRAP1) TGFBRAP1 Bos taurus (Bovine) TR37943_c5_g1_i1 Q0PMG2 MDGA1_MOUSE 1.00E-10 GO:0046658; GO:0021799; GO:0001764 anchored to plasma membrane; cerebral cortex radially oriented cell migration; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 Mdga1 Mus musculus (Mouse) TR37943_c5_g1_i2 P28824 NRP1_XENLA 1.00E-10 GO:0001525; GO:0007411; GO:0007155; GO:0035767; GO:0008201; GO:0016021; GO:0046872; GO:0009887; GO:0017154; GO:0048010; GO:0005021 angiogenesis; axon guidance; cell adhesion; endothelial cell chemotaxis; heparin binding; integral to membrane; metal ion binding; organ morphogenesis; semaphorin receptor activity; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor-activated receptor activity IPR000421; IPR008985; IPR000859; IPR008979; IPR000998; IPR014648; IPR022579; IPR027146; Neuropilin-1 (A5 antigen) (A5 protein) nrp1 Xenopus laevis (African clawed frog) TR37943_c5_g1_i4 Q9QWJ9 NRP1_RAT 7.00E-09 GO:0030424; GO:0007411; GO:0007413; GO:0007155; GO:0009986; GO:0035729; GO:0005829; GO:0016358; GO:0060666; GO:0035767; GO:0030426; GO:0007507; GO:0008201; GO:0048012; GO:0016021; GO:0046872; GO:0048843; GO:0005883; GO:0043025; GO:0009887; GO:0001569; GO:0005886; GO:0048008; GO:0050731; GO:0009611; GO:0017154; GO:0048485; GO:0021636; GO:0048010; GO:0005021 axon; axon guidance; axonal fasciculation; cell adhesion; cell surface; cellular response to hepatocyte growth factor stimulus; cytosol; dendrite development; dichotomous subdivision of terminal units involved in salivary gland branching; endothelial cell chemotaxis; growth cone; heart development; heparin binding; hepatocyte growth factor receptor signaling pathway; integral to membrane; metal ion binding; negative regulation of axon extension involved in axon guidance; neurofilament; neuronal cell body; organ morphogenesis; patterning of blood vessels; plasma membrane; platelet-derived growth factor receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; response to wounding; semaphorin receptor activity; sympathetic nervous system development; trigeminal nerve morphogenesis; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor-activated receptor activity IPR000421; IPR008985; IPR000859; IPR008979; IPR000998; IPR014648; IPR022579; IPR027146; Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304) Nrp1 Rattus norvegicus (Rat) TR37943_c5_g2_i1 A2AJA7 AEGP_MOUSE 3.00E-09 GO:0016021; GO:0015031 integral to membrane; protein transport IPR008985; IPR023415; IPR002172; IPR000998; Apical endosomal glycoprotein (MAM domain-containing protein 4) Mamdc4 Aegp Gm995 Mus musculus (Mouse) TR37943_c5_g3_i1 Q5VYJ5 CJ112_HUMAN 4.00E-12 GO:0016021 integral to membrane IPR008985; IPR023415; IPR002172; IPR000998; MAM and LDL-receptor class A domain-containing protein C10orf112 C10orf112 Homo sapiens (Human) TR37943_c5_g3_i3 Q0WYX8 MDGA1_CHICK 9.00E-12 GO:0046658; GO:0001764 anchored to plasma membrane; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 MDGA1 Gallus gallus (Chicken) TR37943_c5_g3_i4 P28175 LFC_TACTR 7.00E-07 GO:0030246; GO:0007155; GO:0005576; GO:0042381; GO:0006508; GO:0004252 carbohydrate binding; cell adhesion; extracellular region; hemolymph coagulation; proteolysis; serine-type endopeptidase activity IPR001304; IPR016186; IPR016187; IPR000742; IPR013032; IPR004043; IPR001254; IPR018114; IPR001314; IPR000436; IPR009003; Limulus clotting factor C (FC) (EC 3.4.21.84) [Cleaved into: Limulus clotting factor C heavy chain; Limulus clotting factor C light chain; Limulus clotting factor C chain A; Limulus clotting factor C chain B] Tachypleus tridentatus (Japanese horseshoe crab) TR37944_c0_g3_i2 Q2TB18 ASTE1_HUMAN 9.00E-43 GO:0006281; GO:0004518; GO:0090305 DNA repair; nuclease activity; nucleic acid phosphodiester bond hydrolysis IPR026832; IPR006085; Protein asteroid homolog 1 ASTE1 HT001 Homo sapiens (Human) TR37944_c0_g3_i3 Q1LYL8 ASTE1_DANRE 1.00E-43 IPR026832; Protein asteroid homolog 1 aste1 si:dkey-11p23.5 Danio rerio (Zebrafish) (Brachydanio rerio) TR37944_c0_g3_i4 Q1LYL8 ASTE1_DANRE 2.00E-44 IPR026832; Protein asteroid homolog 1 aste1 si:dkey-11p23.5 Danio rerio (Zebrafish) (Brachydanio rerio) TR37946_c0_g1_i1 Q3T133 TMED9_BOVIN 3.00E-06 GO:0048205; GO:0005794; GO:0007030; GO:0005789; GO:0033116; GO:0016021; GO:0010638; GO:0015031 COPI coating of Golgi vesicle; Golgi apparatus; Golgi organization; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; positive regulation of organelle organization; protein transport IPR009038; Transmembrane emp24 domain-containing protein 9 (p24 family protein alpha-2) (p24alpha2) TMED9 Bos taurus (Bovine) TR37946_c0_g2_i3 Q7Z7H5 TMED4_HUMAN 4.00E-07 GO:0005789; GO:0016021; GO:0043123; GO:0015031; GO:0004871 endoplasmic reticulum membrane; integral to membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein transport; signal transducer activity IPR009038; Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (GMP25iso) (Putative NF-kappa-B-activating protein 156) (p24 family protein alpha-3) (p24alpha3) TMED4 ERS25 Homo sapiens (Human) TR37946_c1_g1_i4 D3ZTX0 TMED7_RAT 3.00E-44 GO:0030663; GO:0012507; GO:0005794; GO:0005783; GO:0005789; GO:0005793; GO:0033116; GO:0016021; GO:0015031 COPI-coated vesicle membrane; ER to Golgi transport vesicle membrane; Golgi apparatus; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; protein transport IPR009038; IPR015718; Transmembrane emp24 domain-containing protein 7 (p24 family protein gamma-3) (p24gamma3) (p27) Tmed7 Rattus norvegicus (Rat) TR37950_c3_g2_i1 Q13360 ZN177_HUMAN 2.00E-22 GO:0003677; GO:0046872; GO:0000122; GO:0005634; GO:0006351 "DNA binding; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 177 ZNF177 Homo sapiens (Human) TR37952_c0_g1_i1 Q9Z2J0 S23A1_MOUSE 3.00E-43 GO:0008520; GO:0016324; GO:0009925; GO:0007420; GO:0005903; GO:0005737; GO:0033300; GO:0016021; GO:0043229; GO:0030324; GO:0009636; GO:0070890; GO:0070904 L-ascorbate:sodium symporter activity; apical plasma membrane; basal plasma membrane; brain development; brush border; cytoplasm; dehydroascorbic acid transporter activity; integral to membrane; intracellular organelle; lung development; response to toxic substance; sodium-dependent L-ascorbate transmembrane transporter activity; transepithelial L-ascorbic acid transport IPR006043; Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (Yolk sac permease-like molecule 3) Slc23a1 Svct1 Yspl3 Mus musculus (Mouse) TR37952_c1_g1_i1 Q8VC51 WAP53_MOUSE 6.00E-53 GO:0015030; GO:0003723; GO:0005737; GO:0005730; GO:0051973; GO:0005697; GO:0032203 Cajal body; RNA binding; cytoplasm; nucleolus; positive regulation of telomerase activity; telomerase holoenzyme complex; telomere formation via telomerase IPR015943; IPR001680; IPR017986; Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein encoded by RNA antisense to p53) Wrap53 Tcab1 Wdr79 Mus musculus (Mouse) TR37952_c1_g2_i1 O59762 GNR1_SCHPO 4.00E-10 GO:0005829; GO:0005834; GO:0090029; GO:0007165 cytosol; heterotrimeric G-protein complex; negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion; signal transduction IPR015943; IPR001680; IPR017986; Guanine nucleotide-binding protein negative regulator 1 (G protein negative regulator 1) (WD repeat-containing protein gnr1) gnr1 SPCC1020.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR37953_c0_g1_i2 Q9EQU5 SET_MOUSE 2.00E-108 GO:0003677; GO:0005829; GO:0005783; GO:0043524; GO:0045892; GO:0005654; GO:0006334; GO:0005634; GO:0048471; GO:0043234 "DNA binding; cytosol; endoplasmic reticulum; negative regulation of neuron apoptotic process; negative regulation of transcription, DNA-dependent; nucleoplasm; nucleosome assembly; nucleus; perinuclear region of cytoplasm; protein complex" IPR002164; Protein SET (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) Set Mus musculus (Mouse) TR37954_c1_g2_i1 O94919 ENDD1_HUMAN 5.00E-15 GO:0004519; GO:0005576; GO:0046872; GO:0003676; GO:0090305 endonuclease activity; extracellular region; metal ion binding; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis IPR001604; IPR020821; Endonuclease domain-containing 1 protein (EC 3.1.30.-) ENDOD1 KIAA0830 Homo sapiens (Human) TR37954_c1_g2_i2 P81203 NUC1_CUNEE 2.00E-07 GO:0004519; GO:0005576; GO:0046872; GO:0003676; GO:0090305 endonuclease activity; extracellular region; metal ion binding; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis IPR018524; IPR001604; IPR020821; Nuclease C1 (EC 3.1.30.-) NUC1CE Cunninghamella echinulata var. echinulata TR37954_c1_g2_i3 Q14249 NUCG_HUMAN 4.00E-10 GO:0006309; GO:0004519; GO:0001701; GO:0046872; GO:0005739; GO:0003676; GO:0043065; GO:0046677; GO:0034612 apoptotic DNA fragmentation; endonuclease activity; in utero embryonic development; metal ion binding; mitochondrion; nucleic acid binding; positive regulation of apoptotic process; response to antibiotic; response to tumor necrosis factor IPR018524; IPR001604; IPR020821; "Endonuclease G, mitochondrial (Endo G) (EC 3.1.30.-)" ENDOG Homo sapiens (Human) TR37957_c0_g1_i2 O43657 TSN6_HUMAN 3.00E-17 GO:0016021; GO:0043123; GO:0004871 integral to membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-6 (Tspan-6) (A15 homolog) (Putative NF-kappa-B-activating protein 321) (T245 protein) (Tetraspanin TM4-D) (Transmembrane 4 superfamily member 6) TSPAN6 TM4SF6 UNQ767/PRO1560 Homo sapiens (Human) TR37957_c0_g1_i3 Q568Y5 TSN11_RAT 1.00E-27 GO:0016021 integral to membrane IPR000301; IPR018499; IPR008952; Tetraspanin-11 (Tspan-11) Tspan11 Rattus norvegicus (Rat) TR37958_c1_g1_i1 Q6DI51 NDK6_DANRE 4.00E-53 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0046872; GO:0004550 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; metal ion binding; nucleoside diphosphate kinase activity IPR001564; IPR023005; Nucleoside diphosphate kinase 6 (NDK 6) (NDP kinase 6) (EC 2.7.4.6) nme6 ndpkz6 Danio rerio (Zebrafish) (Brachydanio rerio) TR37958_c1_g1_i10 Q6DI51 NDK6_DANRE 3.00E-50 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0046872; GO:0004550 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; metal ion binding; nucleoside diphosphate kinase activity IPR001564; IPR023005; Nucleoside diphosphate kinase 6 (NDK 6) (NDP kinase 6) (EC 2.7.4.6) nme6 ndpkz6 Danio rerio (Zebrafish) (Brachydanio rerio) TR37958_c1_g1_i11 O75414 NDK6_HUMAN 2.00E-48 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0006915; GO:0046872; GO:0005739; GO:0043066; GO:0030308; GO:0045839; GO:0004550; GO:0009142 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; apoptotic process; metal ion binding; mitochondrion; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of mitosis; nucleoside diphosphate kinase activity; nucleoside triphosphate biosynthetic process IPR001564; IPR023005; Nucleoside diphosphate kinase 6 (NDK 6) (NDP kinase 6) (EC 2.7.4.6) (Inhibitor of p53-induced apoptosis-alpha) (IPIA-alpha) (nm23-H6) NME6 Homo sapiens (Human) TR37958_c1_g1_i2 Q4L6H1 NDK_STAHJ 2.00E-24 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0005737; GO:0046872; GO:0004550 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; cytoplasm; metal ion binding; nucleoside diphosphate kinase activity IPR001564; IPR023005; Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) (Nucleoside-2-P kinase) ndk SH1445 Staphylococcus haemolyticus (strain JCSC1435) TR37958_c1_g1_i3 O75414 NDK6_HUMAN 3.00E-48 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0006915; GO:0046872; GO:0005739; GO:0043066; GO:0030308; GO:0045839; GO:0004550; GO:0009142 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; apoptotic process; metal ion binding; mitochondrion; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of mitosis; nucleoside diphosphate kinase activity; nucleoside triphosphate biosynthetic process IPR001564; IPR023005; Nucleoside diphosphate kinase 6 (NDK 6) (NDP kinase 6) (EC 2.7.4.6) (Inhibitor of p53-induced apoptosis-alpha) (IPIA-alpha) (nm23-H6) NME6 Homo sapiens (Human) TR37958_c1_g1_i4 A8AAF5 NDK_IGNH4 2.00E-20 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0005737; GO:0046872; GO:0004550 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; cytoplasm; metal ion binding; nucleoside diphosphate kinase activity IPR001564; Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) (Nucleoside-2-P kinase) ndk Igni_0725 Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) TR37958_c1_g1_i5 P90666 TXND3_ANTCR 9.00E-19 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0030154; GO:0045454; GO:0007275; GO:0004550; GO:0007283 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; cell differentiation; cell redox homeostasis; multicellular organismal development; nucleoside diphosphate kinase activity; spermatogenesis IPR001564; IPR023005; IPR012336; IPR017937; IPR013766; Thioredoxin domain-containing protein 3 homolog (Intermediate chain 1) (NME/NM23 family member 8) NME8 IC1 Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR37958_c1_g1_i6 P47921 NDK_SOLLC 8.00E-17 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0046872; GO:0004550 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; metal ion binding; nucleoside diphosphate kinase activity IPR001564; IPR023005; Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) (Fragment) Solanum lycopersicum (Tomato) (Lycopersicon esculentum) TR37958_c1_g1_i8 B1I1P4 NDK_DESAP 3.00E-23 GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0005737; GO:0046872; GO:0004550 ATP binding; CTP biosynthetic process; GTP biosynthetic process; UTP biosynthetic process; cytoplasm; metal ion binding; nucleoside diphosphate kinase activity IPR001564; Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) (Nucleoside-2-P kinase) ndk Daud_0088 Desulforudis audaxviator (strain MP104C) TR37959_c0_g1_i1 Q60989 XIAP_MOUSE 3.00E-25 GO:0016055; GO:0005737; GO:0005829; GO:1990001; GO:0043066; GO:0043524; GO:0051402; GO:0005634; GO:0048471; GO:0043234; GO:0004842; GO:0008270 P53702; Q9JIY5 Wnt receptor signaling pathway; cytoplasm; cytosol; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of neuron apoptotic process; neuron apoptotic process; nucleus; perinuclear region of cytoplasm; protein complex; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (mIAP-3) (mIAP3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) Xiap Aipa Api3 Birc4 Miha Mus musculus (Mouse) TR37960_c6_g1_i2 O14264 YFP9_SCHPO 4.00E-06 GO:0003865; GO:0019408; GO:0006488; GO:0030176 3-oxo-5-alpha-steroid 4-dehydrogenase activity; dolichol biosynthetic process; dolichol-linked oligosaccharide biosynthetic process; integral to endoplasmic reticulum membrane IPR001104; Uncharacterized protein C7D4.09c SPAC7D4.09c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR37960_c6_g1_i3 Q17428 PORED_CAEEL 4.00E-38 GO:0019348; GO:0006488; GO:0005789; GO:0016021; GO:0016627; GO:0016095; GO:0006486 "dolichol metabolic process; dolichol-linked oligosaccharide biosynthetic process; endoplasmic reticulum membrane; integral to membrane; oxidoreductase activity, acting on the CH-CH group of donors; polyprenol catabolic process; protein glycosylation" IPR001104; Protein modification; protein glycosylation. Polyprenol reductase (EC 1.3.1.94) B0024.13 Caenorhabditis elegans TR37960_c6_g1_i4 Q9UT20 YFY8_SCHPO 2.00E-07 GO:0003865; GO:0005783; GO:0005789; GO:0016021; GO:0008202 3-oxo-5-alpha-steroid 4-dehydrogenase activity; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; steroid metabolic process IPR016636; IPR001104; Uncharacterized protein C9.08c SPAC9.08c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR37960_c6_g1_i7 Q8AVI9 PORED_XENLA 1.00E-39 GO:0003865; GO:0047751; GO:0019348; GO:0006488; GO:0005783; GO:0005789; GO:0016021; GO:0016628; GO:0016095; GO:0006486 "3-oxo-5-alpha-steroid 4-dehydrogenase activity; cholestenone 5-alpha-reductase activity; dolichol metabolic process; dolichol-linked oligosaccharide biosynthetic process; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; polyprenol catabolic process; protein glycosylation" IPR001104; Protein modification; protein glycosylation. Polyprenol reductase (EC 1.3.1.94) (3-oxo-5-alpha-steroid 4-dehydrogenase 3) (EC 1.3.1.22) (Steroid 5-alpha-reductase 3) (S5AR 3) (SR type 3) srd5a3 Xenopus laevis (African clawed frog) TR37961_c2_g1_i2 B4XSY6 LECAB_MACLB 7.00E-06 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Snaclec A11 (C-type lectin A11) Macrovipera lebetina (Levantine viper) (Vipera lebetina) TR37961_c2_g1_i5 Q66S03 NATTE_THANI 6.00E-10 GO:0030246; GO:0005576; GO:0006954; GO:0046872 carbohydrate binding; extracellular region; inflammatory response; metal ion binding IPR001304; IPR016186; IPR016187; Galactose-specific lectin nattectin (CTL) Thalassophryne nattereri (Niquim) TR37961_c2_g2_i2 Q5KU26 COL12_HUMAN 3.00E-08 GO:0009756; GO:0005581; GO:0030666; GO:0005534; GO:0045087; GO:0016021; GO:0030169; GO:0046872; GO:0006910; GO:0005886; GO:0051260; GO:0005044; GO:0008329 "carbohydrate mediated signaling; collagen; endocytic vesicle membrane; galactose binding; innate immune response; integral to membrane; low-density lipoprotein particle binding; metal ion binding; phagocytosis, recognition; plasma membrane; protein homooligomerization; scavenger receptor activity; signaling pattern recognition receptor activity" IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-12 (Collectin placenta protein 1) (CL-P1) (hCL-P1) (Nurse cell scavenger receptor 2) (Scavenger receptor class A member 4) (Scavenger receptor with C-type lectin) COLEC12 CLP1 NSR2 SCARA4 SRCL Homo sapiens (Human) TR37961_c2_g2_i3 P86854 PLCL_MYTGA 2.00E-20 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR37961_c2_g2_i5 Q61282 PGCA_MOUSE 3.00E-12 GO:0005604; GO:0030246; GO:0001502; GO:0002063; GO:0030199; GO:0005540; GO:0046872; GO:0030166 basement membrane; carbohydrate binding; cartilage condensation; chondrocyte development; collagen fibril organization; hyaluronic acid binding; metal ion binding; proteoglycan biosynthetic process IPR001304; IPR016186; IPR018378; IPR016187; IPR007110; IPR013783; IPR003006; IPR013106; IPR003596; IPR000538; IPR000436; Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) Acan Agc Agc1 Mus musculus (Mouse) TR37961_c2_g2_i6 Q67EQ1 CLC4E_RAT 1.00E-07 GO:0030246; GO:0006955; GO:0016021; GO:0050715; GO:0004872 carbohydrate binding; immune response; integral to membrane; positive regulation of cytokine secretion; receptor activity IPR001304; IPR016186; IPR018378; IPR016187; C-type lectin domain family 4 member E (C-type lectin superfamily member 9) (Macrophage-inducible C-type lectin) Clec4e Clecsf9 Mincle Rattus norvegicus (Rat) TR37961_c2_g2_i8 Q96E93 KLRG1_HUMAN 1.00E-06 GO:0030246; GO:0007166; GO:0006968; GO:0006954; GO:0045087; GO:0016021; GO:0005886; GO:0004872; GO:0050776 carbohydrate binding; cell surface receptor signaling pathway; cellular defense response; inflammatory response; innate immune response; integral to membrane; plasma membrane; receptor activity; regulation of immune response IPR001304; IPR016186; IPR016187; Killer cell lectin-like receptor subfamily G member 1 (C-type lectin domain family 15 member A) (ITIM-containing receptor MAFA-L) (MAFA-like receptor) (Mast cell function-associated antigen) KLRG1 CLEC15A MAFA MAFAL Homo sapiens (Human) TR37962_c0_g1_i1 Q17IN5 MED18_AEDAE 4.00E-65 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR019095; Mediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18) MED18 AAEL002284 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR37962_c0_g1_i2 Q0VCD4 MED18_BOVIN 9.00E-71 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR019095; Mediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18) MED18 Bos taurus (Bovine) TR37962_c0_g1_i3 Q9XZT1 MED18_DROME 2.00E-61 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR019095; Mediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18) (dp28b) MED18 arm CG14802 Drosophila melanogaster (Fruit fly) TR37962_c0_g2_i2 Q7QGX9 MED18_ANOGA 8.00E-22 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR019095; Mediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18) MED18 AGAP010936 Anopheles gambiae (African malaria mosquito) TR37963_c2_g1_i1 Q7T163 KDIS_DANRE 4.00E-23 GO:0016021; GO:0005770; GO:0007399 integral to membrane; late endosome; nervous system development IPR002110; IPR020683; IPR011646; Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) kidins220 arms kidins220b si:dkeyp-7f8.3 si:dz119j18.2 zgc:63531 Danio rerio (Zebrafish) (Brachydanio rerio) TR37964_c0_g1_i2 Q6NUT3 MFS12_HUMAN 2.00E-134 GO:0016021; GO:0005765; GO:0006810 integral to membrane; lysosomal membrane; transport IPR016196; Major facilitator superfamily domain-containing protein 12 MFSD12 C19orf28 Homo sapiens (Human) TR37966_c1_g3_i2 Q6NYI0 HERP2_DANRE 6.00E-27 GO:0016021; GO:0006986 integral to membrane; response to unfolded protein IPR000626; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein herpud2 zgc:56020 zgc:76968 Danio rerio (Zebrafish) (Brachydanio rerio) TR37966_c2_g1_i1 Q9D9I4 TBC20_MOUSE 3.00E-111 GO:0005097; GO:0016021; GO:0032851 Rab GTPase activator activity; integral to membrane; positive regulation of Rab GTPase activity IPR000195; TBC1 domain family member 20 Tbc1d20 Mus musculus (Mouse) TR37966_c2_g1_i2 Q8BM85 TBCK_MOUSE 7.00E-07 GO:0005097; GO:0032851; GO:0016772 "Rab GTPase activator activity; positive regulation of Rab GTPase activity; transferase activity, transferring phosphorus-containing groups" IPR011009; IPR000719; IPR000195; TBC domain-containing protein kinase-like protein Tbck Mus musculus (Mouse) TR37967_c0_g2_i1 Q16932 STX_APLCA 5.00E-12 GO:0016021; GO:0006886; GO:0006836; GO:0016192 integral to membrane; intracellular protein transport; neurotransmitter transport; vesicle-mediated transport IPR015708; IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin Aplysia californica (California sea hare) TR37968_c1_g1_i1 Q20480 SIR41_CAEEL 2.00E-94 GO:0070403; GO:0016787; GO:0046872; GO:0005759; GO:0005739 NAD+ binding; hydrolase activity; metal ion binding; mitochondrial matrix; mitochondrion IPR003000; IPR026591; IPR026587; IPR026590; NAD-dependent protein deacetylase sir-2.2 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 2) sir-2.2 F46G10.7 Caenorhabditis elegans TR37968_c1_g1_i2 Q1JQC6 SIR4_BOVIN 4.00E-121 GO:0003950; GO:0070403; GO:0034979; GO:0006541; GO:0046872; GO:0005759; GO:0046322; GO:0046676; GO:0034983; GO:0046889; GO:0006471; GO:0006974; GO:0072350 NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent protein deacetylase activity; glutamine metabolic process; metal ion binding; mitochondrial matrix; negative regulation of fatty acid oxidation; negative regulation of insulin secretion; peptidyl-lysine deacetylation; positive regulation of lipid biosynthetic process; protein ADP-ribosylation; response to DNA damage stimulus; tricarboxylic acid metabolic process IPR003000; IPR026591; IPR026587; IPR026590; NAD-dependent protein deacetylase sirtuin-4 (EC 3.5.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4) SIRT4 Bos taurus (Bovine) TR37968_c2_g1_i1 Q9NK57 NIF3L_DROME 9.00E-43 GO:0003934 GTP cyclohydrolase I activity IPR002678; "Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1." Putative GTP cyclohydrolase 1 type 2 (EC 3.5.4.16) (GTP cyclohydrolase I) (NIF3-like protein 1) (Protein anon-35F/36A) anon-35F/36A CG4278 Drosophila melanogaster (Fruit fly) TR37968_c2_g1_i5 Q05B89 NIF3L_BOVIN 2.00E-81 GO:0003934; GO:0005737; GO:0045893 "GTP cyclohydrolase I activity; cytoplasm; positive regulation of transcription, DNA-dependent" IPR002678; IPR017222; "Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1." Putative GTP cyclohydrolase 1 type 2 NIF3L1 (EC 3.5.4.16) (GTP cyclohydrolase I) (NIF3-like protein 1) NIF3L1 Bos taurus (Bovine) TR37968_c3_g1_i1 Q1JQC6 SIR4_BOVIN 2.00E-34 GO:0003950; GO:0070403; GO:0034979; GO:0006541; GO:0046872; GO:0005759; GO:0046322; GO:0046676; GO:0034983; GO:0046889; GO:0006471; GO:0006974; GO:0072350 NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent protein deacetylase activity; glutamine metabolic process; metal ion binding; mitochondrial matrix; negative regulation of fatty acid oxidation; negative regulation of insulin secretion; peptidyl-lysine deacetylation; positive regulation of lipid biosynthetic process; protein ADP-ribosylation; response to DNA damage stimulus; tricarboxylic acid metabolic process IPR003000; IPR026591; IPR026587; IPR026590; NAD-dependent protein deacetylase sirtuin-4 (EC 3.5.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4) SIRT4 Bos taurus (Bovine) TR37969_c0_g1_i2 Q24307 IAP2_DROME 2.00E-08 GO:0050829; GO:0043066; GO:0043154; GO:0061057; GO:0006964; GO:0033160; GO:0070534; GO:0007423; GO:0008270 "defense response to Gram-negative bacterium; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; peptidoglycan recognition protein signaling pathway; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; positive regulation of protein import into nucleus, translocation; protein K63-linked ubiquitination; sensory organ development; zinc ion binding" IPR001370; IPR001841; IPR013083; Apoptosis 2 inhibitor (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) (dIAP2) Iap2 DIHA ILP CG8293 Drosophila melanogaster (Fruit fly) TR37969_c0_g1_i3 P41435 IAP1_NPVAC 4.00E-11 GO:0006915; GO:0008270 apoptotic process; zinc ion binding IPR001370; IPR001841; IPR013083; Apoptosis inhibitor 1 (IAP-1) IAP1 Autographa californica nuclear polyhedrosis virus (AcMNPV) TR37971_c4_g1_i2 Q8UVR5 BAZ1A_XENLA 7.00E-10 GO:0005634; GO:0006355; GO:0006351; GO:0008270 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001487; IPR018359; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Bromodomain adjacent to zinc finger domain protein 1A (ATP-utilizing chromatin assembly and remodeling factor 1) (xACF1) (Fragment) baz1a acf1 Xenopus laevis (African clawed frog) TR37972_c2_g2_i3 Q9D5R3 CCD41_MOUSE 3.00E-85 GO:0005814; GO:0042384; GO:0048278 centriole; cilium assembly; vesicle docking Centrosomal protein of 83 kDa (Cep83) (Coiled-coil domain-containing protein 41) Ccdc41 Cep83 Mus musculus (Mouse) TR37972_c2_g2_i4 Q66H89 CCD41_RAT 6.00E-84 GO:0005814; GO:0042384 centriole; cilium assembly Centrosomal protein of 83 kDa (Cep83) (Coiled-coil domain-containing protein 41) Ccdc41 Cep83 Rattus norvegicus (Rat) TR37973_c0_g1_i2 Q8N957 ANKF1_HUMAN 1.00E-88 IPR002110; IPR020683; IPR003961; IPR013783; Ankyrin repeat and fibronectin type-III domain-containing protein 1 ANKFN1 Homo sapiens (Human) TR37974_c2_g1_i2 Q96MM6 HS12B_HUMAN 1.00E-78 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR37974_c2_g1_i4 B8H6Q1 DNAK_ARTCA 4.00E-07 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK Achl_3621 Arthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360) TR37974_c2_g1_i5 Q05647 DNAK_ERYRH 1.00E-06 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK Erysipelothrix rhusiopathiae TR37974_c2_g1_i7 Q96MM6 HS12B_HUMAN 3.00E-77 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR37976_c0_g1_i1 Q12830 BPTF_HUMAN 2.00E-26 GO:0016589; GO:0009952; GO:0007420; GO:0006338; GO:0005737; GO:0001892; GO:0007492; GO:0000122; GO:0045893; GO:0043565; GO:0008134; GO:0006351; GO:0008270 Q71DI3; P62805 "NURF complex; anterior/posterior pattern specification; brain development; chromatin remodeling; cytoplasm; embryonic placenta development; endoderm development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription factor binding; transcription, DNA-dependent; zinc ion binding" IPR001487; IPR018359; IPR004022; IPR018500; IPR018501; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) BPTF FAC1 FALZ Homo sapiens (Human) TR37976_c0_g1_i2 Q92831 KAT2B_HUMAN 0 GO:0031672; GO:0005671; GO:0031674; GO:0018076; GO:0007219; GO:0000125; GO:0042641; GO:0007050; GO:0032869; GO:0006338; GO:0004861; GO:0043966; GO:0004402; GO:0000776; GO:0004468; GO:0019048; GO:0008285; GO:0045736; GO:0045944; GO:0032403; GO:0019901; GO:0010835; GO:0003713; GO:0006361; GO:0006367 P03255; P03255-2; O60566; Q92793; P03129; Q09472; Q16665; P02299; P84040; Q96EB6; Q8IXJ6; Q16594; O88898-2; Q15672; P22415 A band; Ada2/Gcn5/Ada3 transcription activator complex; I band; N-terminal peptidyl-lysine acetylation; Notch signaling pathway; PCAF complex; actomyosin; cell cycle arrest; cellular response to insulin stimulus; chromatin remodeling; cyclin-dependent protein serine/threonine kinase inhibitor activity; histone H3 acetylation; histone acetyltransferase activity; kinetochore; lysine N-acetyltransferase activity; modulation by virus of host morphology or physiology; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of transcription from RNA polymerase II promoter; protein complex binding; protein kinase binding; regulation of protein ADP-ribosylation; transcription coactivator activity; transcription initiation from RNA polymerase I promoter; transcription initiation from RNA polymerase II promoter IPR016181; IPR001487; IPR018359; IPR000182; IPR016376; IPR009464; Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) KAT2B PCAF Homo sapiens (Human) TR37976_c0_g2_i1 Q9JHD2 KAT2A_MOUSE 7.00E-112 GO:0005671; GO:0010484; GO:0030914; GO:0008283; GO:0003682; GO:0043966; GO:0044154; GO:0004402; GO:0043997; GO:0016578; GO:0001701; GO:0022037; GO:0030901; GO:0072686; GO:0035264; GO:0001843; GO:0031647; GO:0006355; GO:0001756; GO:0021537; GO:0003713; GO:0033276; GO:0006351 Q80YV3 "Ada2/Gcn5/Ada3 transcription activator complex; H3 histone acetyltransferase activity; STAGA complex; cell proliferation; chromatin binding; histone H3 acetylation; histone H3-K14 acetylation; histone acetyltransferase activity; histone acetyltransferase activity (H4-K12 specific); histone deubiquitination; in utero embryonic development; metencephalon development; midbrain development; mitotic spindle; multicellular organism growth; neural tube closure; regulation of protein stability; regulation of transcription, DNA-dependent; somitogenesis; telencephalon development; transcription coactivator activity; transcription factor TFTC complex; transcription, DNA-dependent" IPR016181; IPR001487; IPR018359; IPR000182; IPR016376; IPR009464; Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (MmGCN5) (Lysine acetyltransferase 2A) Kat2a Gcn5l2 Mus musculus (Mouse) TR37978_c5_g1_i1 Q05546 TENR_RAT 4.00E-18 GO:0007155; GO:0007162; GO:0007399; GO:0005578 cell adhesion; negative regulation of cell adhesion; nervous system development; proteinaceous extracellular matrix IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin-R (TN-R) (Janusin) (Neural recognition molecule J1-160/180) (Restrictin) Tnr Rattus norvegicus (Rat) TR37978_c5_g1_i2 Q00546 TENR_CHICK 3.00E-54 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR013032; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin-R (TN-R) (Restrictin) TNR Gallus gallus (Chicken) TR37978_c5_g1_i4 A2AV25 FBCD1_MOUSE 5.00E-59 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 Fibcd1 Mus musculus (Mouse) TR37978_c5_g1_i5 Q5M8C6 FGL1_RAT 1.00E-48 GO:0005576 extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein 1 Fgl1 Rattus norvegicus (Rat) TR37979_c0_g2_i1 Q9C0D5 TANC1_HUMAN 1.00E-14 GO:0043679; GO:0030054; GO:0030425; GO:0097062; GO:0007520; GO:0043025; GO:0014069; GO:0045211; GO:0008542 axon terminus; cell junction; dendrite; dendritic spine maintenance; myoblast fusion; neuronal cell body; postsynaptic density; postsynaptic membrane; visual learning IPR002110; IPR020683; IPR027417; IPR013026; IPR011990; IPR013105; IPR019734; "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" TANC1 KIAA1728 Homo sapiens (Human) TR37979_c0_g2_i2 Q9ULJ7 ANR50_HUMAN 2.00E-12 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) TR37979_c0_g2_i3 Q9HCD6 TANC2_HUMAN 3.00E-16 GO:0001701 in utero embryonic development IPR002110; IPR020683; IPR027417; IPR013026; IPR011990; IPR019734; "Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2)" TANC2 KIAA1148 KIAA1636 Homo sapiens (Human) TR37979_c1_g1_i1 P60043 PA2B1_NAJSG 2.00E-22 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Basic phospholipase A2 1 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (Fragment) Naja sagittifera (Andaman cobra) TR37980_c1_g2_i1 Q9YI36 SUCB2_COLLI 3.00E-156 GO:0005524; GO:0005525; GO:0005739; GO:0004776; GO:0006099 ATP binding; GTP binding; mitochondrion; succinate-CoA ligase (GDP-forming) activity; tricarboxylic acid cycle IPR013650; IPR013815; IPR013816; IPR005811; IPR017866; IPR005809; IPR016102; Carbohydrate metabolism; tricarboxylic acid cycle. "Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG) (Fragment)" SUCLG2 Columba livia (Domestic pigeon) TR37980_c2_g5_i2 Q8BGK6 YLAT2_MOUSE 2.00E-146 GO:0015171; GO:0015297; GO:0016323; GO:0016021 amino acid transmembrane transporter activity; antiporter activity; basolateral plasma membrane; integral to membrane IPR002293; Y+L amino acid transporter 2 (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2) Slc7a6 Kiaa0245 Mus musculus (Mouse) TR37982_c3_g1_i1 P36898 BMR1B_MOUSE 5.00E-160 GO:0005524; GO:0030509; GO:0001502; GO:0002062; GO:0009953; GO:0006703; GO:0006954; GO:0016021; GO:0035108; GO:0046872; GO:0001550; GO:0030501; GO:1902043; GO:0045669; GO:0060041; GO:0031290; GO:0005025; GO:0007179 O35182 "ATP binding; BMP signaling pathway; cartilage condensation; chondrocyte differentiation; dorsal/ventral pattern formation; estrogen biosynthetic process; inflammatory response; integral to membrane; limb morphogenesis; metal ion binding; ovarian cumulus expansion; positive regulation of bone mineralization; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of osteoblast differentiation; retina development in camera-type eye; retinal ganglion cell axon guidance; transforming growth factor beta receptor activity, type I; transforming growth factor beta receptor signaling pathway" IPR000472; IPR011009; IPR000719; IPR017441; IPR008271; IPR003605; Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (Activin receptor-like kinase 6) (ALK-6) (Serine/threonine-protein kinase receptor R6) (SKR6) (CD antigen CDw293) Bmpr1b Acvrlk6 Mus musculus (Mouse) TR37983_c2_g1_i2 Q6GN42 CTL4_XENLA 2.00E-112 GO:0016021 integral to membrane IPR007603; Choline transporter-like protein 4 (Solute carrier family 44 member 4) slc44a4 ctl4 Xenopus laevis (African clawed frog) TR37984_c0_g1_i2 Q5R4R7 K1045_PONAB 5.00E-39 GO:0046872 metal ion binding IPR019786; IPR011011; IPR013083; Protein KIAA1045 homolog Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR37985_c0_g1_i2 Q62210 BIRC2_MOUSE 2.00E-20 GO:0035631; GO:0006915; GO:0005737; GO:0009898; GO:0070266; GO:0060546; GO:1902443; GO:0005634; GO:0001890; GO:0043123; GO:0043161; GO:0070936; GO:0070534; GO:0042981; GO:0051726; GO:2000377; GO:0006355; GO:0003713; GO:0006351; GO:0004842; GO:0008270 "CD40 receptor complex; apoptotic process; cytoplasm; internal side of plasma membrane; necroptosis; negative regulation of necroptosis; negative regulation of ripoptosome assembly involved in necroptosis; nucleus; placenta development; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; protein K63-linked ubiquitination; regulation of apoptotic process; regulation of cell cycle; regulation of reactive oxygen species metabolic process; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (Inhibitor of apoptosis protein 2) (IAP-2) (mIAP-2) (mIAP2) Birc2 Birc3 Iap2 Mus musculus (Mouse) TR37985_c0_g1_i5 Q8JHV9 BIR7A_XENLA 5.00E-28 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR37985_c0_g1_i9 O62640 PIAP_PIG 5.00E-28 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR37986_c1_g1_i1 Q9UL26 RB22A_HUMAN 3.00E-75 GO:0019003; GO:0005525; GO:0003924; GO:0015629; GO:0005769; GO:0006897; GO:0010008; GO:0007032; GO:0045335; GO:0030670; GO:0005886; GO:0015031; GO:0001726; GO:0007264 Q15075 GDP binding; GTP binding; GTPase activity; actin cytoskeleton; early endosome; endocytosis; endosome membrane; endosome organization; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane; protein transport; ruffle; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-22A (Rab-22) RAB22A RAB22 Homo sapiens (Human) TR37988_c1_g1_i1 O89110 CASP8_MOUSE 4.00E-41 GO:0030690; GO:0006919; GO:0001525; GO:0071260; GO:0005813; GO:0097153; GO:0031264; GO:0008625; GO:0007507; GO:0097284; GO:0030225; GO:0005739; GO:0043124; GO:0060546; GO:0001841; GO:0043123; GO:2001238; GO:0045651; GO:0045862; GO:0051603; GO:0070243; GO:0034612 P10275; P19091; P25446; Q9D8Y7 Noc1p-Noc2p complex; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; death-inducing signaling complex; extrinsic apoptotic signaling pathway via death domain receptors; heart development; hepatocyte apoptotic process; macrophage differentiation; mitochondrion; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of necroptosis; neural tube formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of macrophage differentiation; positive regulation of proteolysis; proteolysis involved in cellular protein catabolic process; regulation of thymocyte apoptotic process; response to tumor necrosis factor IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] Casp8 Mus musculus (Mouse) TR37989_c8_g2_i2 Q5SSM3 RHG44_MOUSE 2.00E-112 GO:0005096; GO:0005737; GO:0043547; GO:0007165 GTPase activator activity; cytoplasm; positive regulation of GTPase activity; signal transduction IPR027267; IPR004148; IPR008936; IPR000198; Rho GTPase-activating protein 44 (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2) Arhgap44 Rich2 Mus musculus (Mouse) TR37989_c8_g2_i3 Q07960 RHG01_HUMAN 3.00E-13 GO:0030675; GO:0005100; GO:0007266; GO:0005070; GO:0005829; GO:0043231; GO:0005886; GO:0001726 P60953; P60953-2; P61586 Rac GTPase activator activity; Rho GTPase activator activity; Rho protein signal transduction; SH3/SH2 adaptor activity; cytosol; intracellular membrane-bounded organelle; plasma membrane; ruffle IPR001251; IPR008936; IPR000198; Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP) ARHGAP1 CDC42GAP RHOGAP1 Homo sapiens (Human) TR37989_c8_g2_i4 Q8BL80 RHG22_MOUSE 4.00E-17 GO:0005096; GO:0001525; GO:0030154; GO:0005737; GO:0005634; GO:0005543; GO:0043547; GO:0006355; GO:0007165; GO:0006351 "GTPase activator activity; angiogenesis; cell differentiation; cytoplasm; nucleus; phospholipid binding; positive regulation of GTPase activity; regulation of transcription, DNA-dependent; signal transduction; transcription, DNA-dependent" IPR011993; IPR001849; IPR008936; IPR000198; Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22) (p68RacGAP) Arhgap22 Mus musculus (Mouse) TR37989_c8_g2_i6 Q5SSM3 RHG44_MOUSE 2.00E-113 GO:0005096; GO:0005737; GO:0043547; GO:0007165 GTPase activator activity; cytoplasm; positive regulation of GTPase activity; signal transduction IPR027267; IPR004148; IPR008936; IPR000198; Rho GTPase-activating protein 44 (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2) Arhgap44 Rich2 Mus musculus (Mouse) TR37989_c8_g2_i7 Q5T5U3 RHG21_HUMAN 4.00E-14 GO:0005096; GO:0005794; GO:0000139; GO:0007030; GO:0030054; GO:0030659; GO:0005856; GO:0051683; GO:0051684; GO:0072384; GO:0005543; GO:0043547; GO:0007165 P84078; P29692 GTPase activator activity; Golgi apparatus; Golgi membrane; Golgi organization; cell junction; cytoplasmic vesicle membrane; cytoskeleton; establishment of Golgi localization; maintenance of Golgi location; organelle transport along microtubule; phospholipid binding; positive regulation of GTPase activity; signal transduction IPR001478; IPR011993; IPR001849; IPR008936; IPR000198; Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21) ARHGAP21 ARHGAP10 KIAA1424 Homo sapiens (Human) TR37989_c8_g3_i1 Q64674 SPEE_MOUSE 8.00E-103 GO:0008295; GO:0004766 spermidine biosynthetic process; spermidine synthase activity IPR001045; Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase) Srm Mus musculus (Mouse) TR37989_c8_g3_i2 Q64674 SPEE_MOUSE 1.00E-86 GO:0008295; GO:0004766 spermidine biosynthetic process; spermidine synthase activity IPR001045; Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase) Srm Mus musculus (Mouse) TR37989_c8_g3_i3 Q9XY92 SPEE_DICDI 1.00E-83 GO:0008295; GO:0004766 spermidine biosynthetic process; spermidine synthase activity IPR001045; Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase) spsA DDB_G0268630 Dictyostelium discoideum (Slime mold) TR37990_c0_g1_i1 Q0WYX8 MDGA1_CHICK 8.00E-09 GO:0046658; GO:0001764 anchored to plasma membrane; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 MDGA1 Gallus gallus (Chicken) TR37990_c0_g3_i1 P28824 NRP1_XENLA 2.00E-06 GO:0001525; GO:0007411; GO:0007155; GO:0035767; GO:0008201; GO:0016021; GO:0046872; GO:0009887; GO:0017154; GO:0048010; GO:0005021 angiogenesis; axon guidance; cell adhesion; endothelial cell chemotaxis; heparin binding; integral to membrane; metal ion binding; organ morphogenesis; semaphorin receptor activity; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor-activated receptor activity IPR000421; IPR008985; IPR000859; IPR008979; IPR000998; IPR014648; IPR022579; IPR027146; Neuropilin-1 (A5 antigen) (A5 protein) nrp1 Xenopus laevis (African clawed frog) TR37991_c2_g1_i3 Q6GM59 MOT12_XENLA 3.00E-37 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 Xenopus laevis (African clawed frog) TR37991_c2_g1_i4 Q6ZSM3 MOT12_HUMAN 1.00E-37 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) SLC16A12 MCT12 Homo sapiens (Human) TR37993_c0_g1_i1 Q5E9C8 MMAC_BOVIN 9.00E-81 GO:0031419; GO:0009236; GO:0005739 cobalamin binding; cobalamin biosynthetic process; mitochondrion Cofactor biosynthesis; adenosylcobalamin biosynthesis. Methylmalonic aciduria and homocystinuria type C protein homolog MMACHC Bos taurus (Bovine) TR37993_c0_g1_i2 Q5ZL21 MMAC_CHICK 1.00E-82 Methylmalonic aciduria and homocystinuria type C protein homolog MMACHC RCJMB04_8d5 Gallus gallus (Chicken) TR37994_c0_g1_i1 Q6XUX0 DUSTY_CHICK 8.00E-21 GO:0005524; GO:0005737; GO:0018108; GO:0004674; GO:0004712; GO:0004713 ATP binding; cytoplasm; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (Receptor-interacting serine/threonine-protein kinase 5) DSTYK RIPK5 Gallus gallus (Chicken) TR37994_c0_g1_i2 A2CI34 DUSTY_PIMPR 5.00E-21 GO:0005524; GO:0005737; GO:0018108; GO:0004674; GO:0004712; GO:0004713 ATP binding; cytoplasm; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (Receptor-interacting serine/threonine-protein kinase 5) dstyk ripk5 Pimephales promelas (Fathead minnow) TR37995_c7_g1_i1 Q92796 DLG3_HUMAN 4.00E-11 GO:0032281; GO:0007411; GO:0005737; GO:0043198; GO:0001736; GO:0045197; GO:0030426; GO:0004385; GO:0008285; GO:0010923; GO:0043025; GO:0019902; GO:0005886; GO:0045202; GO:0007268; GO:0005923 P62136 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; axon guidance; cytoplasm; dendritic shaft; establishment of planar polarity; establishment or maintenance of epithelial cell apical/basal polarity; growth cone; guanylate kinase activity; negative regulation of cell proliferation; negative regulation of phosphatase activity; neuronal cell body; phosphatase binding; plasma membrane; synapse; synaptic transmission; tight junction IPR008145; IPR008144; IPR020590; IPR016313; IPR019590; IPR027417; IPR001478; IPR019583; IPR001452; Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) DLG3 KIAA1232 Homo sapiens (Human) TR37995_c7_g1_i4 Q0V8R5 IL16_BOVIN 5.00E-19 GO:0006935; GO:0005737; GO:0005615; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "chemotaxis; cytoplasm; extracellular space; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR020450; IPR001478; Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] IL16 Bos taurus (Bovine) TR37996_c0_g1_i2 Q9WVB4 SLIT3_MOUSE 4.00E-32 GO:0035385; GO:0061364; GO:0048846; GO:0007411; GO:0005509; GO:0032870; GO:0005615; GO:0050919; GO:0030308; GO:0008285; GO:0070100; GO:0010629; GO:0009887; GO:0005102; GO:0051414 Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; axon guidance; calcium ion binding; cellular response to hormone stimulus; extracellular space; negative chemotaxis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of chemokine-mediated signaling pathway; negative regulation of gene expression; organ morphogenesis; receptor binding; response to cortisol stimulus IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 3 protein (Slit-3) (Slit3) Slit3 Mus musculus (Mouse) TR37996_c0_g1_i6 Q8RY65 NIK2_ARATH 6.00E-07 GO:0005524; GO:0006952; GO:0016021; GO:0019048; GO:0005886; GO:0004674 ATP binding; defense response; integral to membrane; modulation by virus of host morphology or physiology; plasma membrane; protein serine/threonine kinase activity IPR013320; IPR011009; IPR013210; IPR000719; IPR017441; IPR008271; Protein NSP-INTERACTING KINASE 2 (EC 2.7.11.1) (LRR receptor-like serine/threonine-protein kinase NIK2) NIK2 At3g25560 MWL2.18 Arabidopsis thaliana (Mouse-ear cress) TR37996_c0_g2_i1 Q99PI8 RTN4R_MOUSE 2.00E-13 GO:0031225; GO:0007409; GO:0009986; GO:0005783; GO:0005886 anchored to membrane; axonogenesis; cell surface; endoplasmic reticulum; plasma membrane IPR000483; IPR001611; IPR003591; IPR000372; Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor) Rtn4r Nogor Mus musculus (Mouse) TR37999_c2_g1_i1 Q96RW7 HMCN1_HUMAN 7.00E-13 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR37999_c2_g1_i2 Q95116 TSP2_BOVIN 2.00E-16 GO:0005509; GO:0007155; GO:0005576; GO:0008201 calcium ion binding; cell adhesion; extracellular region; heparin binding IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR024731; IPR001791; IPR000884; IPR015455; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-2 (Corticotropin-induced secreted protein) (CISP) THBS2 TSP-2 TSP2 Bos taurus (Bovine) TR37999_c2_g1_i4 P35440 TSP2_CHICK 3.00E-14 GO:0005604; GO:0005509; GO:0007155; GO:0008201; GO:0016525 basement membrane; calcium ion binding; cell adhesion; heparin binding; negative regulation of angiogenesis IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR024731; IPR001791; IPR000884; IPR015455; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-2 THBS2 TSP2 Gallus gallus (Chicken) TR380_c0_g1_i1 Q460N5 PAR14_HUMAN 2.00E-12 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR38000_c0_g4_i3 Q9USQ7 MUG71_SCHPO 1.00E-110 GO:0005524; GO:0005829; GO:0017178; GO:0007126; GO:0005634; GO:0017183 ATP binding; cytosol; diphthine-ammonia ligase activity; meiosis; nucleus; peptidyl-diphthamide biosynthetic process from peptidyl-histidine IPR002761; IPR013813; IPR014729; IPR006175; Protein modification; peptidyl-diphthamide biosynthesis. Diphthine--ammonia ligase (EC 6.3.1.14) (Diphthamide synthase) (Diphthamide synthetase) mug71 SPBC577.12 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38000_c0_g4_i9 A2RV01 ATBD4_DANRE 3.00E-51 GO:0005524; GO:0017178; GO:0017183 ATP binding; diphthine-ammonia ligase activity; peptidyl-diphthamide biosynthetic process from peptidyl-histidine IPR002761; IPR014729; Protein modification; peptidyl-diphthamide biosynthesis. Diphthine--ammonia ligase (EC 6.3.1.14) (ATP-binding domain-containing protein 4) (Diphthamide synthase) (Diphthamide synthetase) (Protein DPH6 homolog) dph6 atpbd4 zgc:110758 Danio rerio (Zebrafish) (Brachydanio rerio) TR38004_c1_g1_i1 Q924D0 RT4I1_MOUSE 2.00E-82 GO:0005739; GO:0016491; GO:0008270 mitochondrion; oxidoreductase activity; zinc ion binding IPR013154; IPR002085; IPR011032; IPR016040; IPR002364; IPR027061; "Reticulon-4-interacting protein 1, mitochondrial (NOGO-interacting mitochondrial protein)" Rtn4ip1 Nimp Mus musculus (Mouse) TR38004_c1_g1_i2 Q924D0 RT4I1_MOUSE 1.00E-88 GO:0005739; GO:0016491; GO:0008270 mitochondrion; oxidoreductase activity; zinc ion binding IPR013154; IPR002085; IPR011032; IPR016040; IPR002364; IPR027061; "Reticulon-4-interacting protein 1, mitochondrial (NOGO-interacting mitochondrial protein)" Rtn4ip1 Nimp Mus musculus (Mouse) TR38004_c1_g1_i3 O42909 YBI2_SCHPO 7.00E-24 GO:0005794; GO:0004024; GO:0005783; GO:0005739; GO:0008270 "Golgi apparatus; alcohol dehydrogenase activity, zinc-dependent; endoplasmic reticulum; mitochondrion; zinc ion binding" IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; Zinc-type alcohol dehydrogenase-like protein C16A3.02c (EC 1.-.-.-) SPBC16A3.02c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38005_c0_g1_i2 Q9TUL9 TIMP3_HORSE 1.00E-15 GO:0005604; GO:0071310; GO:0046872; GO:0008191; GO:0051045 basement membrane; cellular response to organic substance; metal ion binding; metalloendopeptidase inhibitor activity; negative regulation of membrane protein ectodomain proteolysis IPR001134; IPR001820; IPR008993; IPR027465; IPR015612; Metalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) (TIMP-3) TIMP3 Equus caballus (Horse) TR38005_c0_g1_i4 Q9W6B4 TIMP3_SCYTO 5.00E-16 GO:0046872; GO:0008191; GO:0005578 metal ion binding; metalloendopeptidase inhibitor activity; proteinaceous extracellular matrix IPR001134; IPR001820; IPR008993; IPR027465; IPR015612; Metalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) (TIMP-3) TIMP3 Scyliorhinus torazame (Cloudy catshark) TR38006_c0_g1_i1 O95714 HERC2_HUMAN 2.00E-08 GO:0006281; GO:0032183; GO:0005814; GO:0005737; GO:0005085; GO:0020037; GO:0006886; GO:0005634; GO:0042787; GO:0004842; GO:0008270 DNA repair; SUMO binding; centriole; cytoplasm; guanyl-nucleotide exchange factor activity; heme binding; intracellular protein transport; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR004939; IPR006624; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) HERC2 Homo sapiens (Human) TR38006_c0_g1_i2 O95714 HERC2_HUMAN 5.00E-10 GO:0006281; GO:0032183; GO:0005814; GO:0005737; GO:0005085; GO:0020037; GO:0006886; GO:0005634; GO:0042787; GO:0004842; GO:0008270 DNA repair; SUMO binding; centriole; cytoplasm; guanyl-nucleotide exchange factor activity; heme binding; intracellular protein transport; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR004939; IPR006624; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) HERC2 Homo sapiens (Human) TR38007_c1_g6_i1 Q10474 LYS5_SCHPO 4.00E-20 GO:0005829; GO:0008897; GO:0009085; GO:0009059; GO:0000287; GO:0005634 cytosol; holo-[acyl-carrier-protein] synthase activity; lysine biosynthetic process; macromolecule biosynthetic process; magnesium ion binding; nucleus IPR008278; L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASD-PPT) (EC 2.7.8.7) lys7 SPAC17C9.02c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38007_c1_g6_i2 Q9F4F7 FFP_BACIU 3.00E-16 GO:0017000; GO:0006633; GO:0008897; GO:0009059; GO:0000287 antibiotic biosynthetic process; fatty acid biosynthetic process; holo-[acyl-carrier-protein] synthase activity; macromolecule biosynthetic process; magnesium ion binding IPR008278; IPR004568; 4'-phosphopantetheinyl transferase ffp (EC 2.7.8.-) (Fengycin synthase-activating enzyme) ffp sfp Bacillus subtilis TR38007_c1_g6_i3 Q6DJH2 ADPPT_XENLA 7.00E-80 GO:0005737; GO:0006633; GO:0008897; GO:0009059; GO:0000287 cytoplasm; fatty acid biosynthetic process; holo-[acyl-carrier-protein] synthase activity; macromolecule biosynthetic process; magnesium ion binding IPR008278; IPR004568; L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC 2.7.8.-) (4'-phosphopantetheinyl transferase) (Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase) (AASD-PPT) aasdhppt Xenopus laevis (African clawed frog) TR38008_c0_g1_i1 P55865 CAS1A_XENLA 4.00E-09 GO:0006915; GO:0004197; GO:0005737; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis; regulation of apoptotic process IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-1-A (CASP-1-A) (EC 3.4.22.36) (Interleukin-1 beta convertase homolog A) (xICE-A) casp1-a casp1a Xenopus laevis (African clawed frog) TR38008_c0_g2_i3 Q14790 CASP8_HUMAN 2.00E-43 GO:0031265; GO:0030690; GO:0035666; GO:0006919; GO:0001525; GO:0044297; GO:0006921; GO:0071260; GO:0005813; GO:0097153; GO:0005829; GO:0031264; GO:0097191; GO:0007507; GO:0045087; GO:0097193; GO:0030225; GO:0045121; GO:0005741; GO:0019048; GO:0043124; GO:0001841; GO:0043005; GO:0070423; GO:0005634; GO:0043123; GO:0045651; GO:1900740; GO:0045862; GO:0051291; GO:0051603; GO:2001239; GO:0046677; GO:0032025; GO:0009409; GO:0032355; GO:0045471; GO:0032496; GO:0034612; GO:0097342; GO:0034138; GO:0034142 P51572; Q92851; Q9UKL3; O15519-1; Q13618; Q13158; P25445; P48023; Q13418; Q9UDY8; O60936; P29350; Q13546; O00220 CD95 death-inducing signaling complex; Noc1p-Noc2p complex; TRIF-dependent toll-like receptor signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cell body; cellular component disassembly involved in execution phase of apoptosis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; cytosol; death-inducing signaling complex; extrinsic apoptotic signaling pathway; heart development; innate immune response; intrinsic apoptotic signaling pathway; macrophage differentiation; membrane raft; mitochondrial outer membrane; modulation by virus of host morphology or physiology; negative regulation of I-kappaB kinase/NF-kappaB cascade; neural tube formation; neuron projection; nucleotide-binding oligomerization domain containing signaling pathway; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macrophage differentiation; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of proteolysis; protein heterooligomerization; proteolysis involved in cellular protein catabolic process; regulation of extrinsic apoptotic signaling pathway in absence of ligand; response to antibiotic; response to cobalt ion; response to cold; response to estradiol stimulus; response to ethanol; response to lipopolysaccharide; response to tumor necrosis factor; ripoptosome; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] CASP8 MCH5 Homo sapiens (Human) TR38008_c0_g3_i1 P55213 CASP3_RAT 2.00E-13 GO:0071407; GO:0004197; GO:0008234; GO:0005829; GO:0034349; GO:0021766; GO:0035556; GO:0007611; GO:0030182; GO:0016005; GO:0043525; GO:0006508; GO:0010165; GO:0043200; GO:0046677; GO:0032025; GO:0042493; GO:0032355; GO:0051384; GO:0009749; GO:0042542; GO:0001666; GO:0032496; GO:0035094; GO:0042060 cellular response to organic cyclic compound; cysteine-type endopeptidase activity; cysteine-type peptidase activity; cytosol; glial cell apoptotic process; hippocampus development; intracellular signal transduction; learning or memory; neuron differentiation; phospholipase A2 activator activity; positive regulation of neuron apoptotic process; proteolysis; response to X-ray; response to amino acid stimulus; response to antibiotic; response to cobalt ion; response to drug; response to estradiol stimulus; response to glucocorticoid stimulus; response to glucose stimulus; response to hydrogen peroxide; response to hypoxia; response to lipopolysaccharide; response to nicotine; wound healing IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (IRP) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] Casp3 Cpp32 Rattus norvegicus (Rat) TR38009_c5_g1_i3 P0C7V8 DC8L2_HUMAN 2.00E-23 IPR015943; IPR001680; IPR017986; DDB1- and CUL4-associated factor 8-like protein 2 (WD repeat-containing protein 42C) DCAF8L2 WDR42C Homo sapiens (Human) TR38009_c5_g1_i5 Q5R9B8 DCAF6_PONAB 2.00E-71 GO:0080008; GO:0005634; GO:0016567 Cul4-RING ubiquitin ligase complex; nucleus; protein ubiquitination IPR000048; IPR015943; IPR001680; IPR017986; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 6 (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP) DCAF6 IQWD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38009_c5_g1_i6 Q5TAQ9 DCAF8_HUMAN 8.00E-23 GO:0080008; GO:0016567 P52294; Q99750; Q99873; O43463; P12520 Cul4-RING ubiquitin ligase complex; protein ubiquitination IPR015943; IPR001680; IPR017986; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A) DCAF8 H326 WDR42A Homo sapiens (Human) TR38009_c5_g1_i7 Q5R9B8 DCAF6_PONAB 1.00E-72 GO:0080008; GO:0005634; GO:0016567 Cul4-RING ubiquitin ligase complex; nucleus; protein ubiquitination IPR000048; IPR015943; IPR001680; IPR017986; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 6 (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP) DCAF6 IQWD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38009_c5_g1_i8 Q8N7N5 DCAF8_MOUSE 2.00E-23 GO:0080008; GO:0016567 Cul4-RING ubiquitin ligase complex; protein ubiquitination IPR015943; IPR001680; IPR017986; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A) Dcaf8 D1Ucla4 H326 Wdr42a Mus musculus (Mouse) TR38010_c3_g1_i1 A5WUY6 STPG1_DANRE 5.00E-21 GO:0006915; GO:0005737; GO:0005634 apoptotic process; cytoplasm; nucleus IPR010736; O(6)-methylguanine-induced apoptosis 2 (MAPO2) (Sperm-tail PG-rich repeat-containing protein 1) stpg1 si:dkey-218f9.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR38010_c4_g2_i1 Q5U259 ELV1B_XENLA 4.00E-77 GO:0005938; GO:0007369; GO:0008298; GO:0003730; GO:0048255; GO:0000166; GO:0005634; GO:0008266; GO:0030529 cell cortex; gastrulation; intracellular mRNA localization; mRNA 3'-UTR binding; mRNA stabilization; nucleotide binding; nucleus; poly(U) RNA binding; ribonucleoprotein complex IPR006548; IPR002343; IPR012677; IPR000504; ELAV-like protein 1-B (Protein ElrA-B) (ElrA) elavl1-b elavl1 elrA Xenopus laevis (African clawed frog) TR38010_c4_g2_i10 Q08935 ROC1_NICSY 2.00E-10 GO:0003723; GO:0009507; GO:0006397; GO:0000166; GO:0030529 RNA binding; chloroplast; mRNA processing; nucleotide binding; ribonucleoprotein complex IPR012677; IPR000504; "29 kDa ribonucleoprotein A, chloroplastic (CP29A)" Nicotiana sylvestris (Wood tobacco) (South American tobacco) TR38010_c4_g2_i3 P70372 ELAV1_MOUSE 1.00E-76 GO:0070935; GO:0005737; GO:0003725; GO:0035925; GO:0000166; GO:0005634; GO:0045727 Q03160; Q80ZW7 3'-UTR-mediated mRNA stabilization; cytoplasm; double-stranded RNA binding; mRNA 3'-UTR AU-rich region binding; nucleotide binding; nucleus; positive regulation of translation IPR006548; IPR002343; IPR012677; IPR000504; ELAV-like protein 1 (Elav-like generic protein) (Hu-antigen R) (HuR) (MelG) Elavl1 Elra Hua Mus musculus (Mouse) TR38010_c4_g2_i4 Q6CDH3 PABP_YARLI 2.00E-14 GO:0003723; GO:0005737; GO:0006397; GO:0051028; GO:0000166; GO:0005634; GO:0006417 RNA binding; cytoplasm; mRNA processing; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR012677; IPR006515; IPR002004; IPR000504; "Polyadenylate-binding protein, cytoplasmic and nuclear (PABP) (Poly(A)-binding protein) (Polyadenylate tail-binding protein)" PAB1 YALI0C00539g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR38010_c4_g2_i5 Q5U259 ELV1B_XENLA 6.00E-77 GO:0005938; GO:0007369; GO:0008298; GO:0003730; GO:0048255; GO:0000166; GO:0005634; GO:0008266; GO:0030529 cell cortex; gastrulation; intracellular mRNA localization; mRNA 3'-UTR binding; mRNA stabilization; nucleotide binding; nucleus; poly(U) RNA binding; ribonucleoprotein complex IPR006548; IPR002343; IPR012677; IPR000504; ELAV-like protein 1-B (Protein ElrA-B) (ElrA) elavl1-b elavl1 elrA Xenopus laevis (African clawed frog) TR38010_c4_g2_i7 Q6DEY7 EPAB_XENTR 2.00E-09 GO:0043009; GO:0005737; GO:0031370; GO:0006397; GO:0048255; GO:0060212; GO:0000166; GO:0008143; GO:0043621; GO:0006412 chordate embryonic development; cytoplasm; eukaryotic initiation factor 4G binding; mRNA processing; mRNA stabilization; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; nucleotide binding; poly(A) RNA binding; protein self-association; translation IPR012677; IPR006515; IPR002004; IPR000504; Embryonic polyadenylate-binding protein (Embryonic poly(A)-binding protein) (ePABP) epabp Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38010_c4_g2_i8 P70372 ELAV1_MOUSE 2.00E-35 GO:0070935; GO:0005737; GO:0003725; GO:0035925; GO:0000166; GO:0005634; GO:0045727 Q03160; Q80ZW7 3'-UTR-mediated mRNA stabilization; cytoplasm; double-stranded RNA binding; mRNA 3'-UTR AU-rich region binding; nucleotide binding; nucleus; positive regulation of translation IPR006548; IPR002343; IPR012677; IPR000504; ELAV-like protein 1 (Elav-like generic protein) (Hu-antigen R) (HuR) (MelG) Elavl1 Elra Hua Mus musculus (Mouse) TR38011_c0_g1_i1 A7XYH9 SOBP_BOVIN 1.00E-43 GO:0032184; GO:0046872 SUMO polymer binding; metal ion binding IPR026092; Sine oculis-binding protein homolog (Jackson circler protein 1) SOBP JXC1 Bos taurus (Bovine) TR38012_c1_g2_i2 Q1LV22 F214A_DANRE 4.00E-50 IPR025261; Protein FAM214A fam214a si:dkey-266j9.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR38014_c1_g3_i2 Q9FAW5 AZRB_BACOY 6.00E-07 GO:0050446 azobenzene reductase activity IPR005025; NADPH azoreductase (EC 1.7.1.6) azr Bacillus sp. (strain OY1-2) TR38016_c0_g1_i3 Q8BFS9 ASND1_MOUSE 3.00E-112 GO:0006529; GO:0004066; GO:0006541 asparagine biosynthetic process; asparagine synthase (glutamine-hydrolyzing) activity; glutamine metabolic process IPR001962; IPR017932; IPR000583; IPR014729; Asparagine synthetase domain-containing protein 1 Asnsd1 Mus musculus (Mouse) TR38018_c2_g2_i5 Q9NDM2 GUTR1_DROME 4.00E-18 GO:0004930; GO:0005938; GO:0007281; GO:0035234; GO:0016021; GO:0005886; GO:0007280 G-protein coupled receptor activity; cell cortex; germ cell development; germ cell programmed cell death; integral to membrane; plasma membrane; pole cell migration IPR000276; IPR017452; Protein trapped in endoderm-1 Tre1 CG3171 Drosophila melanogaster (Fruit fly) TR38019_c2_g1_i4 Q5ZI57 TPPC3_CHICK 3.00E-96 GO:0006888; GO:0000139; GO:0030008; GO:0005829; GO:0005783 ER to Golgi vesicle-mediated transport; Golgi membrane; TRAPP complex; cytosol; endoplasmic reticulum IPR024096; IPR007194; IPR016721; Trafficking protein particle complex subunit 3 TRAPPC3 RCJMB04_30c23 Gallus gallus (Chicken) TR38021_c0_g1_i1 Q8BHY8 SNX14_MOUSE 3.00E-107 GO:0007154; GO:0016021; GO:0035091; GO:0015031; GO:0038032 cell communication; integral to membrane; phosphatidylinositol binding; protein transport; termination of G-protein coupled receptor signaling pathway IPR001683; IPR003114; IPR016137; IPR000342; IPR013937; Sorting nexin-14 Snx14 Mus musculus (Mouse) TR38023_c3_g1_i1 Q9UKZ1 CB029_HUMAN 0 GO:0030014; GO:0008283; GO:0005829; GO:0031047; GO:0000289; GO:0005634; GO:0006355; GO:0006417; GO:0006351 A5YKK6; Q9H9A5; Q60809 "CCR4-NOT complex; cell proliferation; cytosol; gene silencing by RNA; nuclear-transcribed mRNA poly(A) tail shortening; nucleus; regulation of transcription, DNA-dependent; regulation of translation; transcription, DNA-dependent" IPR019312; CCR4-NOT transcription complex subunit 11 CNOT11 C2orf29 C40 Homo sapiens (Human) TR38024_c3_g1_i1 Q9QZS7 NPHN_MOUSE 3.00E-36 GO:0007254; GO:0007155; GO:0042995; GO:0032836; GO:0072015; GO:0005887; GO:0007520; GO:0030838; GO:0044062; GO:0007519; GO:0036057 JNK cascade; cell adhesion; cell projection; glomerular basement membrane development; glomerular visceral epithelial cell development; integral to plasma membrane; myoblast fusion; positive regulation of actin filament polymerization; regulation of excretion; skeletal muscle tissue development; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Mus musculus (Mouse) TR38024_c3_g1_i2 Q9QZS7 NPHN_MOUSE 3.00E-37 GO:0007254; GO:0007155; GO:0042995; GO:0032836; GO:0072015; GO:0005887; GO:0007520; GO:0030838; GO:0044062; GO:0007519; GO:0036057 JNK cascade; cell adhesion; cell projection; glomerular basement membrane development; glomerular visceral epithelial cell development; integral to plasma membrane; myoblast fusion; positive regulation of actin filament polymerization; regulation of excretion; skeletal muscle tissue development; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Mus musculus (Mouse) TR38026_c1_g1_i2 Q8BGD9 IF4B_MOUSE 1.00E-34 GO:0000166; GO:0003743 nucleotide binding; translation initiation factor activity IPR012677; IPR000504; Eukaryotic translation initiation factor 4B (eIF-4B) Eif4b Mus musculus (Mouse) TR38027_c1_g3_i1 P56616 UBE2C_XENLA 3.00E-78 GO:0005524; GO:0005680; GO:0031145; GO:0051301; GO:0010458; GO:0010994; GO:0070979; GO:0004842 ATP binding; anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; exit from mitosis; free ubiquitin chain polymerization; protein K11-linked ubiquitination; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 C (EC 6.3.2.19) (UBC-X) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C) ube2c ubch10 ubcx Xenopus laevis (African clawed frog) TR38029_c0_g2_i3 P82289 FABPL_LEPPA 4.00E-06 GO:0005737; GO:0006869; GO:0016918; GO:0019841; GO:0005215 cytoplasm; lipid transport; retinal binding; retinol binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; "Fatty acid-binding protein, liver (Fatty acid-binding protein 1) (Liver basic fatty acid-binding protein) (Lb-FABP) (Liver basic FABP) (Liver-type fatty acid-binding protein) (L-FABP)" fabp1 Lepidosiren paradoxus (South American lungfish) TR38029_c0_g4_i1 Q9UAS2 FABP1_FASGI 6.00E-08 GO:0008289; GO:0005215 lipid binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; Fatty acid-binding protein 1 FABP-1 Fasciola gigantica (Giant liver fluke) TR38030_c0_g2_i4 Q95K09 GCP5_MACFA 7.00E-163 GO:0008274; GO:0005874; GO:0008017; GO:0007020; GO:0000922 gamma-tubulin ring complex; microtubule; microtubule binding; microtubule nucleation; spindle pole IPR007259; Gamma-tubulin complex component 5 (GCP-5) (Fragment) TUBGCP5 GCP5 QtsA-11379 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38030_c0_g2_i6 Q95K09 GCP5_MACFA 1.00E-134 GO:0008274; GO:0005874; GO:0008017; GO:0007020; GO:0000922 gamma-tubulin ring complex; microtubule; microtubule binding; microtubule nucleation; spindle pole IPR007259; Gamma-tubulin complex component 5 (GCP-5) (Fragment) TUBGCP5 GCP5 QtsA-11379 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38034_c1_g2_i1 Q61LC0 S35B3_CAEBR 7.00E-124 GO:0000139; GO:0016021; GO:0055085 Golgi membrane; integral to membrane; transmembrane transport IPR013657; Adenosine 3'-phospho 5'-phosphosulfate transporter 2 (Adenosine 3'-phosphate 5'-phosphosulfate transporter) (PAPS transporter 2) (Solute carrier family 35 member B3 homolog) pst-2 CBG08992 Caenorhabditis briggsae TR38034_c1_g2_i2 Q29EY2 S35B3_DROPS 2.00E-125 GO:0046964; GO:0046963; GO:0005794; GO:0000139; GO:0016021; GO:0007275 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity; 3'-phosphoadenosine 5'-phosphosulfate transport; Golgi apparatus; Golgi membrane; integral to membrane; multicellular organismal development IPR013657; Adenosine 3'-phospho 5'-phosphosulfate transporter 2 (PAPS transporter 2) (Solute carrier family 35 member B3 homolog) Papst2 GA20635 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR38034_c1_g2_i3 Q922Q5 S35B3_MOUSE 2.00E-147 GO:0000139; GO:0016021; GO:0005739; GO:0055085 Golgi membrane; integral to membrane; mitochondrion; transmembrane transport IPR013657; Adenosine 3'-phospho 5'-phosphosulfate transporter 2 (PAPS transporter 2) (Solute carrier family 35 member B3) Slc35b3 Mus musculus (Mouse) TR38035_c0_g1_i3 Q66IH2 TBRG1_XENTR 8.00E-49 GO:0007049; GO:0005634 cell cycle; nucleus IPR003889; IPR003888; Transforming growth factor beta regulator 1 tbrg1 TEgg020g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38036_c0_g1_i1 Q969U6 FBXW5_HUMAN 3.00E-40 GO:0080008; GO:0019005; GO:0031146; GO:0051298; GO:0005737; GO:0007067; GO:0016567 P63208 Cul4-RING ubiquitin ligase complex; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; centrosome duplication; cytoplasm; mitosis; protein ubiquitination IPR001810; IPR015943; IPR001680; IPR017986; Protein modification; protein ubiquitination. F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) FBXW5 FBW5 PP3971 Homo sapiens (Human) TR38036_c0_g1_i2 Q969U6 FBXW5_HUMAN 2.00E-40 GO:0080008; GO:0019005; GO:0031146; GO:0051298; GO:0005737; GO:0007067; GO:0016567 P63208 Cul4-RING ubiquitin ligase complex; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; centrosome duplication; cytoplasm; mitosis; protein ubiquitination IPR001810; IPR015943; IPR001680; IPR017986; Protein modification; protein ubiquitination. F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) FBXW5 FBW5 PP3971 Homo sapiens (Human) TR38036_c1_g1_i2 Q54RX9 RAB5B_DICDI 1.00E-16 GO:0005525; GO:0015031; GO:0007264 GTP binding; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Putative ras-related protein Rab-5B rab5B DDB_G0282847 Dictyostelium discoideum (Slime mold) TR38036_c1_g1_i7 Q86JP3 RAB5A_DICDI 5.00E-21 GO:0005525; GO:0010008; GO:0005886; GO:0015031; GO:0007264 GTP binding; endosome membrane; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-5A rab5A DDB_G0271984 Dictyostelium discoideum (Slime mold) TR38036_c1_g1_i8 Q29RR0 RAB26_BOVIN 2.00E-21 GO:0019002; GO:0005525; GO:0000139; GO:0043001; GO:0035272; GO:0031226; GO:0045055; GO:0017157; GO:0030667; GO:0007264 GMP binding; GTP binding; Golgi membrane; Golgi to plasma membrane protein transport; exocrine system development; intrinsic to plasma membrane; regulated secretory pathway; regulation of exocytosis; secretory granule membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-26 RAB26 Bos taurus (Bovine) TR38038_c6_g2_i1 Q5SSL4 ABR_MOUSE 6.00E-135 GO:0030675; GO:0005089; GO:0030036; GO:0007420; GO:0005829; GO:0042472; GO:0035556; GO:0030336; GO:0050728; GO:0043314; GO:0050885; GO:0005543; GO:0005886; GO:0050766; GO:0032496 Rac GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; actin cytoskeleton organization; brain development; cytosol; inner ear morphogenesis; intracellular signal transduction; negative regulation of cell migration; negative regulation of inflammatory response; negative regulation of neutrophil degranulation; neuromuscular process controlling balance; phospholipid binding; plasma membrane; positive regulation of phagocytosis; response to lipopolysaccharide IPR000008; IPR000219; IPR001331; IPR011993; IPR001849; IPR008936; IPR000198; Active breakpoint cluster region-related protein Abr Mus musculus (Mouse) TR38038_c6_g2_i2 Q54J98 GACX_DICDI 9.00E-12 GO:0005096; GO:0005737; GO:0043547; GO:0007165 GTPase activator activity; cytoplasm; positive regulation of GTPase activity; signal transduction IPR008936; IPR000198; IPR015943; IPR001680; IPR019775; IPR017986; Rho GTPase-activating protein gacX (GTPase activating factor for raC protein X) gacX DDB_G0288205 Dictyostelium discoideum (Slime mold) TR38038_c6_g2_i3 Q9VTU3 RG68F_DROME 7.00E-15 GO:0005100; GO:0007480; GO:0005622; GO:0007165; GO:0007370 Rho GTPase activator activity; imaginal disc-derived leg morphogenesis; intracellular; signal transduction; ventral furrow formation IPR001251; IPR008936; IPR000198; Rho GTPase-activating protein 68F RhoGAP68F CG6811 Drosophila melanogaster (Fruit fly) TR38038_c6_g2_i4 Q5SSL4 ABR_MOUSE 1.00E-135 GO:0030675; GO:0005089; GO:0030036; GO:0007420; GO:0005829; GO:0042472; GO:0035556; GO:0030336; GO:0050728; GO:0043314; GO:0050885; GO:0005543; GO:0005886; GO:0050766; GO:0032496 Rac GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; actin cytoskeleton organization; brain development; cytosol; inner ear morphogenesis; intracellular signal transduction; negative regulation of cell migration; negative regulation of inflammatory response; negative regulation of neutrophil degranulation; neuromuscular process controlling balance; phospholipid binding; plasma membrane; positive regulation of phagocytosis; response to lipopolysaccharide IPR000008; IPR000219; IPR001331; IPR011993; IPR001849; IPR008936; IPR000198; Active breakpoint cluster region-related protein Abr Mus musculus (Mouse) TR38038_c6_g3_i1 Q6PAJ1 BCR_MOUSE 1.00E-19 GO:0005524; GO:0030675; GO:0005089; GO:0030036; GO:0007420; GO:0005829; GO:0042472; GO:0035556; GO:0030336; GO:0050728; GO:0043314; GO:0050885; GO:0005543; GO:0005886; GO:0050766; GO:0004674; GO:0051726; GO:0032496 ATP binding; Rac GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; actin cytoskeleton organization; brain development; cytosol; inner ear morphogenesis; intracellular signal transduction; negative regulation of cell migration; negative regulation of inflammatory response; negative regulation of neutrophil degranulation; neuromuscular process controlling balance; phospholipid binding; plasma membrane; positive regulation of phagocytosis; protein serine/threonine kinase activity; regulation of cell cycle; response to lipopolysaccharide IPR015123; IPR000008; IPR000219; IPR001331; IPR011993; IPR001849; IPR008936; IPR000198; Breakpoint cluster region protein (EC 2.7.11.1) Bcr Kiaa3017 Mus musculus (Mouse) TR38040_c0_g1_i1 Q8BUG5 CAYP2_MOUSE 2.00E-20 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calcyphosin-2 (Calcyphosine-2) Caps2 Mus musculus (Mouse) TR38040_c0_g1_i2 O60041 CALM_KLULA 3.00E-11 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) CMD1 KLLA0B09427g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR38040_c0_g1_i3 Q6P8Y1 CAPSL_MOUSE 1.00E-70 GO:0005509; GO:0005737 calcium ion binding; cytoplasm IPR011992; IPR018247; IPR002048; IPR001125; Calcyphosin-like protein Capsl Mus musculus (Mouse) TR38040_c0_g1_i4 Q13938 CAYP1_HUMAN 1.00E-65 GO:0005509; GO:0005737; GO:0035556; GO:0005634; GO:0005886 calcium ion binding; cytoplasm; intracellular signal transduction; nucleus; plasma membrane IPR011992; IPR018247; IPR002048; Calcyphosin (Calcyphosine) CAPS Homo sapiens (Human) TR38040_c0_g1_i5 Q9D6P8 CALL3_MOUSE 8.00E-13 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-like protein 3 Calml3 Mus musculus (Mouse) TR38040_c0_g2_i1 Q0VCC0 CAYP1_BOVIN 1.00E-66 GO:0005509; GO:0005737; GO:0005634; GO:0005886 calcium ion binding; cytoplasm; nucleus; plasma membrane IPR011992; IPR018247; IPR002048; Calcyphosin (Calcyphosine) CAPS Bos taurus (Bovine) TR38041_c0_g1_i2 Q6QNY0 BL1S3_HUMAN 7.00E-07 GO:0031083; GO:0008089; GO:0048490; GO:0035646; GO:0001654; GO:0032438; GO:0032402; GO:0031175; GO:0030168; GO:0060155; GO:0032816; GO:0006892; GO:0042493; GO:0033299; GO:0030133 Q6QNY1; Q9UL45; Q96EV8 BLOC-1 complex; anterograde axon cargo transport; anterograde synaptic vesicle transport; endosome to melanosome transport; eye development; melanosome organization; melanosome transport; neuron projection development; platelet activation; platelet dense granule organization; positive regulation of natural killer cell activation; post-Golgi vesicle-mediated transport; response to drug; secretion of lysosomal enzymes; transport vesicle IPR017245; Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) BLOC1S3 BLOS3 Homo sapiens (Human) TR38042_c1_g1_i3 Q8R173 ZDHC3_MOUSE 4.00E-40 GO:0005794; GO:0000139; GO:0016021; GO:0016409; GO:0018345; GO:0006605; GO:0008270 Golgi apparatus; Golgi membrane; integral to membrane; palmitoyltransferase activity; protein palmitoylation; protein targeting; zinc ion binding IPR001594; Palmitoyltransferase ZDHHC3 (EC 2.3.1.225) (GABA-A receptor-associated membrane protein 1) (Golgi-specific DHHC zinc finger protein) (Zinc finger DHHC domain-containing protein 3) (DHHC-3) Zdhhc3 Godz Gramp1 Mus musculus (Mouse) TR38042_c1_g1_i5 Q6CPU8 PFA3_KLULA 6.00E-10 GO:0016021; GO:0016746; GO:0005774; GO:0008270 "integral to membrane; transferase activity, transferring acyl groups; vacuolar membrane; zinc ion binding" IPR001594; Palmitoyltransferase PFA3 (EC 2.3.1.225) (Protein fatty acyltransferase 3) PFA3 KLLA0E02068g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR38043_c0_g1_i1 Q9YHB3 RFNG_NOTVI 9.00E-09 GO:0033829; GO:0030173; GO:0046872; GO:0007389 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity; integral to Golgi membrane; metal ion binding; pattern specification process IPR017374; IPR003378; "Beta-1,3-N-acetylglucosaminyltransferase radical fringe (nrFng) (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)" RFNG Notophthalmus viridescens (Eastern newt) (Triturus viridescens) TR38043_c3_g3_i3 Q24342 FNG_DROME 1.00E-80 GO:0005797; GO:0007219; GO:0033829; GO:0001708; GO:0001745; GO:0035017; GO:0007451; GO:0005783; GO:0006004; GO:0007293; GO:0036011; GO:0008587; GO:0030173; GO:0046872; GO:0045746; GO:0006493; GO:0048190 "Golgi medial cisterna; Notch signaling pathway; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity; cell fate specification; compound eye morphogenesis; cuticle pattern formation; dorsal/ventral lineage restriction, imaginal disc; endoplasmic reticulum; fucose metabolic process; germarium-derived egg chamber formation; imaginal disc-derived leg segmentation; imaginal disc-derived wing margin morphogenesis; integral to Golgi membrane; metal ion binding; negative regulation of Notch signaling pathway; protein O-linked glycosylation; wing disc dorsal/ventral pattern formation" IPR017374; IPR003378; Fringe glycosyltransferase (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase) fng CG10580 Drosophila melanogaster (Fruit fly) TR38044_c4_g1_i1 Q09575 YRD6_CAEEL 2.00E-25 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR38044_c8_g1_i1 Q8C206 GP157_MOUSE 2.00E-09 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR022343; IPR017981; IPR000832; IPR017452; Probable G-protein coupled receptor 157 Gpr157 Mus musculus (Mouse) TR38045_c3_g1_i1 O95450 ATS2_HUMAN 2.00E-06 GO:0030574; GO:0030199; GO:0030198; GO:0005576; GO:0030324; GO:0004222; GO:0016485; GO:0005578; GO:0006508; GO:0043588; GO:0007283; GO:0008270 collagen catabolic process; collagen fibril organization; extracellular matrix organization; extracellular region; lung development; metalloendopeptidase activity; protein processing; proteinaceous extracellular matrix; proteolysis; skin development; spermatogenesis; zinc ion binding IPR010294; IPR024079; IPR013275; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS 2) (ADAM-TS2) (ADAMTS-2) (EC 3.4.24.14) (Procollagen I N-proteinase) (PC I-NP) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen N-endopeptidase) (pNPI) ADAMTS2 PCINP PCPNI Homo sapiens (Human) TR38045_c4_g2_i1 P33005 KALM_CHICK 4.00E-06 GO:0007155; GO:0009986; GO:0005576; GO:0004867 cell adhesion; cell surface; extracellular region; serine-type endopeptidase inhibitor activity IPR003961; IPR013783; IPR008197; Anosmin-1 (Kallmann syndrome protein homolog) KAL1 KAL Gallus gallus (Chicken) TR38045_c4_g2_i4 Q9P283 SEM5B_HUMAN 1.00E-08 GO:0030154; GO:0016021; GO:0007399; GO:0004872 cell differentiation; integral to membrane; nervous system development; receptor activity IPR016201; IPR002165; IPR001627; IPR027231; IPR000884; IPR015943; Semaphorin-5B SEMA5B KIAA1445 SEMAG UNQ5867/PRO34001 Homo sapiens (Human) TR38046_c5_g2_i1 E9PW74 GIMD1_MOUSE 1.00E-14 GO:0005525 GTP binding IPR006703; IPR027417; GTPase IMAP family member GIMD1 (GIMAP family P-loop NTPase domain-containing protein 1) Gimd1 Gm5549 Mus musculus (Mouse) TR38046_c5_g2_i11 Q9NUV9 GIMA4_HUMAN 3.00E-35 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR38046_c5_g2_i2 Q9NUV9 GIMA4_HUMAN 2.00E-44 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR38046_c5_g2_i3 P0DJR0 GIMD1_HUMAN 2.00E-08 GO:0005525 GTP binding IPR006703; IPR027417; GTPase IMAP family member GIMD1 (GIMAP family P-loop NTPase domain-containing protein 1) GIMD1 Homo sapiens (Human) TR38046_c5_g2_i8 O81025 P2A03_ARATH 5.00E-27 GO:0005525; GO:0030246 GTP binding; carbohydrate binding IPR006703; IPR027417; IPR025886; Putative protein PHLOEM PROTEIN 2-LIKE A3 (AtPP2-A3) PP2A3 At2g26820 F12C20.14 Arabidopsis thaliana (Mouse-ear cress) TR38047_c0_g1_i1 Q90718 SRF_CHICK 6.00E-63 GO:0003677; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002100; Serum response factor (SRF) (Fragment) SRF Gallus gallus (Chicken) TR38048_c5_g1_i1 O94387 YGSA_SCHPO 3.00E-37 GO:0005524; GO:0004004; GO:0035649; GO:0005634; GO:0006364; GO:0035861; GO:0016180; GO:0043144; GO:0008033 ATP binding; ATP-dependent RNA helicase activity; Nrd1 complex; nucleus; rRNA processing; site of double-strand break; snRNA processing; snoRNA processing; tRNA processing IPR016024; IPR024481; IPR027417; Uncharacterized ATP-dependent helicase C29A10.10c (EC 3.6.4.-) SPBC29A10.10c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38048_c5_g1_i2 Q9BYK8 PR285_HUMAN 3.00E-107 GO:0005524; GO:0003677; GO:0044255; GO:0004386; GO:0030374; GO:0046872; GO:0005654; GO:0045944; GO:0044281; GO:0006351 "ATP binding; DNA binding; cellular lipid metabolic process; helicase activity; ligand-dependent nuclear receptor transcription coactivator activity; metal ion binding; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; small molecule metabolic process; transcription, DNA-dependent" IPR003593; IPR026122; IPR012340; IPR027417; IPR022966; IPR015880; "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) TR38048_c5_g1_i4 O14040 DIS3L_SCHPO 7.00E-09 GO:0000175; GO:0003723; GO:0000932; GO:0005829; GO:0034427; GO:1990074 "3'-5'-exoribonuclease activity; RNA binding; cytoplasmic mRNA processing body; cytosol; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; polyuridylation-dependent mRNA catabolic process" IPR012340; IPR022966; DIS3-like exonuclease 2 (EC 3.1.13.-) dis32 dis3l2 SPAC2C4.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38048_c5_g1_i5 Q9BYK8 PR285_HUMAN 4.00E-15 GO:0005524; GO:0003677; GO:0044255; GO:0004386; GO:0030374; GO:0046872; GO:0005654; GO:0045944; GO:0044281; GO:0006351 "ATP binding; DNA binding; cellular lipid metabolic process; helicase activity; ligand-dependent nuclear receptor transcription coactivator activity; metal ion binding; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; small molecule metabolic process; transcription, DNA-dependent" IPR003593; IPR026122; IPR012340; IPR027417; IPR022966; IPR015880; "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) TR38049_c3_g1_i2 P60892 PRPS1_RAT 0 GO:0006015; GO:0043531; GO:0016208; GO:0006167; GO:0005524; GO:0019003; GO:0030246; GO:0016301; GO:0000287; GO:0031100; GO:0042803; GO:0004749; GO:0002189 5-phosphoribose 1-diphosphate biosynthetic process; ADP binding; AMP binding; AMP biosynthetic process; ATP binding; GDP binding; carbohydrate binding; kinase activity; magnesium ion binding; organ regeneration; protein homodimerization activity; ribose phosphate diphosphokinase activity; ribose phosphate diphosphokinase complex IPR000842; IPR005946; Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) Prps1 Rattus norvegicus (Rat) TR38050_c1_g1_i1 P17970 KCNAB_DROME 4.00E-167 GO:0005251; GO:0008345; GO:0048812; GO:0051260; GO:0001508; GO:0008016; GO:0060025; GO:0008076 delayed rectifier potassium channel activity; larval locomotory behavior; neuron projection morphogenesis; protein homooligomerization; regulation of action potential; regulation of heart contraction; regulation of synaptic activity; voltage-gated potassium channel complex IPR000210; IPR011333; IPR005821; IPR003091; IPR003968; IPR003971; IPR003131; IPR028325; Potassium voltage-gated channel protein Shab Shab CG43128 Drosophila melanogaster (Fruit fly) TR38050_c1_g1_i2 P48547 KCNC1_HUMAN 6.00E-51 GO:0005251; GO:0051260; GO:0007268; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; synaptic transmission; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR005403; IPR003131; IPR028325; Potassium voltage-gated channel subfamily C member 1 (NGK2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4) KCNC1 Homo sapiens (Human) TR38050_c1_g3_i2 P17659 KCNA6_RAT 2.00E-19 GO:0005251; GO:0051260; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003972; IPR004053; IPR003131; IPR028325; Potassium voltage-gated channel subfamily A member 6 (RCK2) (Voltage-gated potassium channel subunit Kv1.6) (Voltage-gated potassium channel subunit Kv2) Kcna6 Rattus norvegicus (Rat) TR38050_c1_g3_i3 P17970 KCNAB_DROME 4.00E-57 GO:0005251; GO:0008345; GO:0048812; GO:0051260; GO:0001508; GO:0008016; GO:0060025; GO:0008076 delayed rectifier potassium channel activity; larval locomotory behavior; neuron projection morphogenesis; protein homooligomerization; regulation of action potential; regulation of heart contraction; regulation of synaptic activity; voltage-gated potassium channel complex IPR000210; IPR011333; IPR005821; IPR003091; IPR003968; IPR003971; IPR003131; IPR028325; Potassium voltage-gated channel protein Shab Shab CG43128 Drosophila melanogaster (Fruit fly) TR38050_c1_g5_i1 Q17ST2 KCNA7_MOUSE 6.00E-23 GO:0005251; GO:0051260; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003972; IPR003131; IPR028325; Potassium voltage-gated channel subfamily A member 7 (Voltage-gated potassium channel subunit Kv1.7) Kcna7 Kcnc7 Mus musculus (Mouse) TR38051_c4_g2_i1 Q9H3H5 GPT_HUMAN 9.00E-166 GO:0006047; GO:0003975; GO:0019408; GO:0006488; GO:0030176; GO:0008963; GO:0043687; GO:0018279; GO:0051259; GO:0016757 "UDP-N-acetylglucosamine metabolic process; UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity; dolichol biosynthetic process; dolichol-linked oligosaccharide biosynthetic process; integral to endoplasmic reticulum membrane; phospho-N-acetylmuramoyl-pentapeptide-transferase activity; post-translational protein modification; protein N-linked glycosylation via asparagine; protein oligomerization; transferase activity, transferring glycosyl groups" IPR000715; Protein modification; protein glycosylation. UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) (GlcNAc-1-P transferase) (G1PT) (GPT) (N-acetylglucosamine-1-phosphate transferase) DPAGT1 DPAGT2 Homo sapiens (Human) TR38051_c4_g3_i1 P24140 GPT_CRIGR 7.00E-09 GO:0003975; GO:0019408; GO:0030176; GO:0008963; GO:0006486; GO:0051259; GO:0016757 "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity; dolichol biosynthetic process; integral to endoplasmic reticulum membrane; phospho-N-acetylmuramoyl-pentapeptide-transferase activity; protein glycosylation; protein oligomerization; transferase activity, transferring glycosyl groups" IPR000715; Protein modification; protein glycosylation. UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) (GlcNAc-1-P transferase) (G1PT) (GPT) (N-acetylglucosamine-1-phosphate transferase) DPAGT1 DPAGT2 GNPTA GTR2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR38052_c5_g3_i1 Q28113 FUT2_BOVIN 3.00E-20 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2)" FUT2 Bos taurus (Bovine) TR38052_c5_g3_i2 Q10980 FUT1_RAT 7.00E-20 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha 1,2-fucosyltransferase A) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" Fut1 Fta Rattus norvegicus (Rat) TR38053_c1_g1_i3 Q29RM5 FEM1A_BOVIN 6.00E-07 GO:0005737; GO:0050728; GO:0051438; GO:0004842 cytoplasm; negative regulation of inflammatory response; regulation of ubiquitin-protein ligase activity; ubiquitin-protein ligase activity IPR002110; IPR020683; IPR011990; Protein modification; protein ubiquitination. Protein fem-1 homolog A (FEM1a) (FEM1-alpha) FEM1A Bos taurus (Bovine) TR38054_c1_g5_i1 P30531 SC6A1_HUMAN 0 GO:0030424; GO:0009986; GO:0051939; GO:0005332; GO:0016021; GO:0005887; GO:0007612; GO:0032229; GO:0007269; GO:0005328; GO:0005886; GO:0014054; GO:0051260; GO:0051592; GO:0042220; GO:0032355; GO:0010288; GO:0014074; GO:0009744; GO:0009636; GO:0055085 "axon; cell surface; gamma-aminobutyric acid import; gamma-aminobutyric acid:sodium symporter activity; integral to membrane; integral to plasma membrane; learning; negative regulation of synaptic transmission, GABAergic; neurotransmitter secretion; neurotransmitter:sodium symporter activity; plasma membrane; positive regulation of gamma-aminobutyric acid secretion; protein homooligomerization; response to calcium ion; response to cocaine; response to estradiol stimulus; response to lead ion; response to purine-containing compound; response to sucrose stimulus; response to toxic substance; transmembrane transport" IPR000175; IPR002980; Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) SLC6A1 GABATR GABT1 GAT1 Homo sapiens (Human) TR38054_c1_g5_i2 Q9NP91 S6A20_HUMAN 6.00E-58 GO:0015171; GO:0016324; GO:0015816; GO:0005887; GO:0005328; GO:0015824 amino acid transmembrane transporter activity; apical plasma membrane; glycine transport; integral to plasma membrane; neurotransmitter:sodium symporter activity; proline transport IPR000175; IPR002438; Sodium- and chloride-dependent transporter XTRP3 (Sodium/imino-acid transporter 1) (Solute carrier family 6 member 20) (Transporter rB21A homolog) SLC6A20 SIT1 XT3 XTRP3 Homo sapiens (Human) TR38055_c1_g1_i1 Q05923 DUS2_HUMAN 3.00E-43 GO:0017017; GO:0001706; GO:0005654; GO:0004725; GO:0008330; GO:0042981 MAP kinase tyrosine/serine/threonine phosphatase activity; endoderm formation; nucleoplasm; protein tyrosine phosphatase activity; protein tyrosine/threonine phosphatase activity; regulation of apoptotic process IPR000340; IPR020422; IPR024950; IPR008343; IPR001763; IPR000387; IPR016130; Dual specificity protein phosphatase 2 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PAC-1) DUSP2 PAC1 Homo sapiens (Human) TR38055_c1_g2_i1 Q64623 DUS1_RAT 5.00E-11 GO:0017017; GO:0007049; GO:0032870; GO:0001706; GO:0035556; GO:0043066; GO:0005654; GO:0043065; GO:0006470; GO:0004725; GO:0008330; GO:0051591; GO:0051592; GO:0032355; GO:0051384; GO:0042542; GO:0009416; GO:0032526; GO:0033574 MAP kinase tyrosine/serine/threonine phosphatase activity; cell cycle; cellular response to hormone stimulus; endoderm formation; intracellular signal transduction; negative regulation of apoptotic process; nucleoplasm; positive regulation of apoptotic process; protein dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/threonine phosphatase activity; response to cAMP; response to calcium ion; response to estradiol stimulus; response to glucocorticoid stimulus; response to hydrogen peroxide; response to light stimulus; response to retinoic acid; response to testosterone stimulus IPR020417; IPR020420; IPR000340; IPR020422; IPR024950; IPR008343; IPR001763; IPR000387; IPR016130; Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100) (Protein-tyrosine phosphatase non-receptor type 16) Dusp1 Cl100 Mkp1 Ptpn16 Rattus norvegicus (Rat) TR38058_c3_g1_i1 B2LT65 TLR2_SHEEP 4.00E-23 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Ovis aries (Sheep) TR38058_c3_g1_i10 B2LT65 TLR2_SHEEP 3.00E-22 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Ovis aries (Sheep) TR38058_c3_g1_i3 Q9JLF7 TLR5_MOUSE 7.00E-12 GO:0002755; GO:0042742; GO:0006954; GO:0045087; GO:0016021; GO:0001819; GO:0050707; GO:0034146; GO:0004888 Q56086; E1WGJ5 MyD88-dependent toll-like receptor signaling pathway; defense response to bacterium; inflammatory response; innate immune response; integral to membrane; positive regulation of cytokine production; regulation of cytokine secretion; toll-like receptor 5 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027176; Toll-like receptor 5 Tlr5 Mus musculus (Mouse) TR38058_c3_g1_i4 O60602 TLR5_HUMAN 2.00E-09 GO:0002755; GO:0071260; GO:0006954; GO:0045087; GO:0016021; GO:0005886; GO:0032757; GO:0034123; GO:0034166; GO:0034146 MyD88-dependent toll-like receptor signaling pathway; cellular response to mechanical stimulus; inflammatory response; innate immune response; integral to membrane; plasma membrane; positive regulation of interleukin-8 production; positive regulation of toll-like receptor signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway IPR000483; IPR001611; IPR003591; IPR000157; Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3) TLR5 TIL3 Homo sapiens (Human) TR38058_c3_g1_i6 Q6GV17 TLR10_BOVIN 1.00E-15 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0034166; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; toll-like receptor 10 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR025875; IPR000157; IPR027182; IPR017241; Toll-like receptor 10 (CD antigen CD290) TLR10 Bos taurus (Bovine) TR38058_c3_g1_i7 B2LT65 TLR2_SHEEP 3.00E-22 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Ovis aries (Sheep) TR38058_c3_g1_i8 O60602 TLR5_HUMAN 3.00E-09 GO:0002755; GO:0071260; GO:0006954; GO:0045087; GO:0016021; GO:0005886; GO:0032757; GO:0034123; GO:0034166; GO:0034146 MyD88-dependent toll-like receptor signaling pathway; cellular response to mechanical stimulus; inflammatory response; innate immune response; integral to membrane; plasma membrane; positive regulation of interleukin-8 production; positive regulation of toll-like receptor signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway IPR000483; IPR001611; IPR003591; IPR000157; Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3) TLR5 TIL3 Homo sapiens (Human) TR38058_c3_g1_i9 Q6T752 TLR2_HORSE 2.00E-20 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR026906; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Equus caballus (Horse) TR38058_c3_g2_i1 O15455 TLR3_HUMAN 7.00E-13 GO:0000139; GO:0007252; GO:0035666; GO:0007250; GO:0060555; GO:0071260; GO:0042742; GO:0051607; GO:0009597; GO:0003725; GO:0036020; GO:0005789; GO:0097191; GO:0006972; GO:0006954; GO:0045087; GO:0005887; GO:0045671; GO:0043123; GO:0046330; GO:0042346; GO:0051092; GO:0045080; GO:0032722; GO:0050729; GO:0045356; GO:0045359; GO:0032728; GO:0045078; GO:0032735; GO:0032755; GO:0032757; GO:0034123; GO:0045944; GO:0032760; GO:0034346; GO:0043330; GO:0034138; GO:0034142; GO:0004888 P27986 Golgi membrane; I-kappaB phosphorylation; TRIF-dependent toll-like receptor signaling pathway; activation of NF-kappaB-inducing kinase activity; activation of necroptosis by extracellular signals; cellular response to mechanical stimulus; defense response to bacterium; defense response to virus; detection of virus; double-stranded RNA binding; endolysosome membrane; endoplasmic reticulum membrane; extrinsic apoptotic signaling pathway; hyperosmotic response; inflammatory response; innate immune response; integral to plasma membrane; negative regulation of osteoclast differentiation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; positive regulation of NF-kappaB import into nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of chemokine biosynthetic process; positive regulation of chemokine production; positive regulation of inflammatory response; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; positive regulation of type III interferon production; response to exogenous dsRNA; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; IPR027173; Toll-like receptor 3 (CD antigen CD283) TLR3 Homo sapiens (Human) TR38059_c0_g2_i3 Q80W54 FACE1_MOUSE 0 GO:0071586; GO:0005789; GO:0016021; GO:0016020; GO:0046872; GO:0004222; GO:0006998; GO:0005637; GO:0030327 CAAX-box protein processing; endoplasmic reticulum membrane; integral to membrane; membrane; metal ion binding; metalloendopeptidase activity; nuclear envelope organization; nuclear inner membrane; prenylated protein catabolic process IPR027057; IPR001915; CAAX prenyl protease 1 homolog (EC 3.4.24.84) (Farnesylated proteins-converting enzyme 1) (FACE-1) (Prenyl protein-specific endoprotease 1) (Zinc metalloproteinase Ste24 homolog) Zmpste24 Face1 Mus musculus (Mouse) TR38060_c2_g1_i1 P34447 YM2A_CAEEL 6.00E-18 GO:0003677; GO:0016246; GO:0000785; GO:0003682; GO:0005634; GO:0008270 DNA binding; RNA interference; chromatin; chromatin binding; nucleus; zinc ion binding IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; "Uncharacterized protein F54F2.2, isoform a" F54F2.2/F54F2.3/F54F2.4 Caenorhabditis elegans TR38060_c2_g1_i2 O54826 AF10_MOUSE 7.00E-104 GO:0005634; GO:0008270 nucleus; zinc ion binding IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Protein AF-10 Mllt10 Af10 Mus musculus (Mouse) TR38065_c0_g1_i2 Q8HZM5 GLNA_CANFA 0 GO:0005524; GO:0004351; GO:0004356; GO:0006542; GO:0005739 ATP binding; glutamate decarboxylase activity; glutamate-ammonia ligase activity; glutamine biosynthetic process; mitochondrion IPR008147; IPR014746; IPR008146; IPR027303; IPR027302; Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate decarboxylase) (EC 4.1.1.15) (Glutamate--ammonia ligase) GLUL Canis familiaris (Dog) (Canis lupus familiaris) TR38066_c1_g1_i1 Q9D494 CO043_MOUSE 3.00E-16 IPR028065; Uncharacterized protein C15orf43 homolog Mus musculus (Mouse) TR38066_c2_g1_i1 Q9UBB5 MBD2_HUMAN 3.00E-74 GO:0043623; GO:0003682; GO:0005737; GO:0000792; GO:0000118; GO:0003729; GO:0042711; GO:0008327; GO:0000122; GO:0045892; GO:0005634; GO:0030177; GO:0042127; GO:0003696; GO:0035197; GO:0006351 "cellular protein complex assembly; chromatin binding; cytoplasm; heterochromatin; histone deacetylase complex; mRNA binding; maternal behavior; methyl-CpG binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of Wnt receptor signaling pathway; regulation of cell proliferation; satellite DNA binding; siRNA binding; transcription, DNA-dependent" IPR016177; IPR025884; IPR001739; Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2) MBD2 Homo sapiens (Human) TR38066_c2_g1_i2 Q8WWY6 MB3L1_HUMAN 4.00E-14 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025884; Methyl-CpG-binding domain protein 3-like 1 (MBD3-like protein 1) MBD3L1 MBD3L Homo sapiens (Human) TR38066_c2_g1_i5 Q9UBB5 MBD2_HUMAN 2.00E-71 GO:0043623; GO:0003682; GO:0005737; GO:0000792; GO:0000118; GO:0003729; GO:0042711; GO:0008327; GO:0000122; GO:0045892; GO:0005634; GO:0030177; GO:0042127; GO:0003696; GO:0035197; GO:0006351 "cellular protein complex assembly; chromatin binding; cytoplasm; heterochromatin; histone deacetylase complex; mRNA binding; maternal behavior; methyl-CpG binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of Wnt receptor signaling pathway; regulation of cell proliferation; satellite DNA binding; siRNA binding; transcription, DNA-dependent" IPR016177; IPR025884; IPR001739; Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2) MBD2 Homo sapiens (Human) TR38066_c2_g1_i6 Q8WWY6 MB3L1_HUMAN 1.00E-14 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025884; Methyl-CpG-binding domain protein 3-like 1 (MBD3-like protein 1) MBD3L1 MBD3L Homo sapiens (Human) TR38067_c2_g3_i2 P04569 SCP1_BRALA 2.00E-11 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; "Sarcoplasmic calcium-binding proteins I, III, and IV (SCP I, III, IV)" Branchiostoma lanceolatum (Common lancelet) (Amphioxus) TR38068_c1_g1_i1 Q95LU3 FBCD1_MACFA 6.00E-59 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38068_c1_g1_i2 Q9WTS8 FCN1_RAT 4.00E-55 GO:0005581; GO:0045087; GO:0046872 collagen; innate immune response; metal ion binding IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) Fcn1 Fcna Rattus norvegicus (Rat) TR38068_c1_g1_i3 Q95LU3 FBCD1_MACFA 7.00E-59 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38069_c0_g1_i2 A0A1F4 EYS_DROME 2.00E-16 GO:0005509; GO:0000902; GO:0005201; GO:0005615; GO:0016021; GO:0005886; GO:0042052; GO:0010378 calcium ion binding; cell morphogenesis; extracellular matrix structural constituent; extracellular space; integral to membrane; plasma membrane; rhabdomere development; temperature compensation of the circadian clock IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Protein eyes shut (Protein spacemaker) eys spam CG33955 Drosophila melanogaster (Fruit fly) TR38070_c3_g1_i2 O75954 TSN9_HUMAN 1.00E-17 GO:0005887 integral to plasma membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-9 (Tspan-9) (Tetraspan NET-5) TSPAN9 NET5 Homo sapiens (Human) TR38070_c3_g1_i3 B3VSC2 TSN9_SHEEP 6.00E-16 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-9 (Tspan-9) (Tetraspan NET-5) TSPAN9 NET5 Ovis aries (Sheep) TR38070_c3_g1_i5 Q6AYR9 TSN1_RAT 4.00E-11 GO:0016021; GO:0005765 integral to membrane; lysosomal membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-1 (Tspan-1) Tspan1 Rattus norvegicus (Rat) TR38071_c2_g1_i1 Q9DDD5 NBEA_CHICK 2.00E-23 GO:0005737; GO:0016020 cytoplasm; membrane Neurobeachin (Fragment) NBEA Gallus gallus (Chicken) TR38071_c3_g1_i1 Q9W4E2 NBEA_DROME 1.00E-174 GO:0042675; GO:0005737; GO:0042462; GO:0016021; GO:0016319; GO:0007528; GO:0043025; GO:0008355; GO:0051018 compound eye cone cell differentiation; cytoplasm; eye photoreceptor cell development; integral to membrane; mushroom body development; neuromuscular junction development; neuronal cell body; olfactory learning; protein kinase A binding IPR016024; IPR000409; IPR008985; IPR013320; IPR010508; IPR023362; IPR015943; IPR001680; IPR017986; Neurobeachin (A-kinase anchor protein 550) (AKAP 550) (Protein rugose) (dAKAP550) rg Akap550 CG6775 Drosophila melanogaster (Fruit fly) TR38071_c6_g1_i1 Q92636 FAN_HUMAN 0 GO:0006672; GO:0005737; GO:0005057 P60709; O95166; Q9H0R8; P50552 ceramide metabolic process; cytoplasm; receptor signaling protein activity IPR000409; IPR004182; IPR023362; IPR015943; IPR001680; IPR017986; Protein FAN (Factor associated with neutral sphingomyelinase activation) (Factor associated with N-SMase activation) NSMAF FAN Homo sapiens (Human) TR38071_c6_g2_i1 Q9D0I6 WSDU1_MOUSE 6.00E-12 GO:0000151; GO:0004842 ubiquitin ligase complex; ubiquitin-protein ligase activity IPR020472; IPR001660; IPR013761; IPR011510; IPR003613; IPR015943; IPR001680; IPR019775; IPR017986; IPR013083; "WD repeat, SAM and U-box domain-containing protein 1" Wdsub1 Mus musculus (Mouse) TR38071_c7_g1_i2 Q8NFP9 NBEA_HUMAN 7.00E-119 GO:0005829; GO:0012505; GO:0005886; GO:0008104; GO:0005802 cytosol; endomembrane system; plasma membrane; protein localization; trans-Golgi network IPR016024; IPR000409; IPR008985; IPR013320; IPR010508; IPR023362; IPR015943; IPR001680; IPR017986; Neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B) NBEA BCL8B KIAA1544 LYST2 Homo sapiens (Human) TR38071_c7_g1_i4 Q19317 NBEA_CAEEL 4.00E-69 GO:0045176; GO:0016197; GO:0016020; GO:0045746; GO:0005634; GO:0048471; GO:0045807; GO:0040028 apical protein localization; endosomal transport; membrane; negative regulation of Notch signaling pathway; nucleus; perinuclear region of cytoplasm; positive regulation of endocytosis; regulation of vulval development IPR011989; IPR016024; IPR000409; IPR008985; IPR013320; IPR010508; IPR023362; IPR015943; IPR001680; IPR017986; Putative neurobeachin homolog (Suppressor enhancer of lin-12) sel-2 F10F2.1 Caenorhabditis elegans TR38073_c0_g2_i1 B1B1A0 LMBL4_MOUSE 7.00E-11 GO:0016568; GO:0005634; GO:0003700; GO:0006351; GO:0008270 "chromatin modification; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR004092; IPR001660; IPR013761; IPR021129; IPR002515; Lethal(3)malignant brain tumor-like protein 4 (L(3)mbt-like protein 4) L3mbtl4 Mus musculus (Mouse) TR38073_c0_g2_i2 Q9QWH1 PHC2_MOUSE 6.00E-39 GO:0003677; GO:0035102; GO:0031519; GO:0007275; GO:0007283; GO:0008270 P25916; P49137; P49138; P23798; Q64028; O35730; Q9CQJ4 DNA binding; PRC1 complex; PcG protein complex; multicellular organismal development; spermatogenesis; zinc ion binding IPR001660; IPR013761; IPR021129; IPR012313; Polyhomeotic-like protein 2 (mPH2) (Early development regulatory protein 2) (p36) Phc2 Edr2 Ph2 Mus musculus (Mouse) TR38073_c0_g2_i4 P78364 PHC1_HUMAN 4.00E-27 GO:0003677; GO:0035102; GO:0071300; GO:0003682; GO:0007275; GO:0016604; GO:0001739; GO:0008270 DNA binding; PRC1 complex; cellular response to retinoic acid; chromatin binding; multicellular organismal development; nuclear body; sex chromatin; zinc ion binding IPR001660; IPR013761; IPR021129; IPR012313; IPR010507; Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1) PHC1 EDR1 PH1 Homo sapiens (Human) TR38074_c0_g1_i2 Q99956 DUS9_HUMAN 2.00E-16 GO:0007254; GO:0017017; GO:0005829; GO:0005783; GO:0005634; GO:0035335; GO:0004725 Q16539; P47811 JNK cascade; MAP kinase tyrosine/serine/threonine phosphatase activity; cytosol; endoplasmic reticulum; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR000340; IPR020422; IPR024950; IPR008343; IPR001763; IPR000387; Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4) DUSP9 MKP4 Homo sapiens (Human) TR38074_c0_g1_i3 Q9NRW4 DUS22_HUMAN 1.00E-20 GO:0006915; GO:0008283; GO:0005737; GO:0000188; GO:0007275; GO:0000122; GO:0005634; GO:0035335; GO:0046330; GO:0004725; GO:0008138; GO:0042127; GO:0007179 apoptotic process; cell proliferation; cytoplasm; inactivation of MAPK activity; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; nucleus; peptidyl-tyrosine dephosphorylation; positive regulation of JNK cascade; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; regulation of cell proliferation; transforming growth factor beta receptor signaling pathway IPR020417; IPR000340; IPR020422; IPR024950; IPR000387; Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phosphatase x) (MAP kinase phosphatase x) (MKP-x) DUSP22 JSP1 LMWDSP2 MKPX Homo sapiens (Human) TR38074_c0_g1_i5 Q5UR74 PTPH_MIMIV 2.00E-09 GO:0035335; GO:0004725; GO:0008138 peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR020422; IPR024950; IPR000387; Putative tyrosine-protein phosphatase R622 (EC 3.1.3.48) MIMI_R622 Acanthamoeba polyphaga mimivirus (APMV) TR38074_c0_g1_i6 Q4V7N3 STYXA_XENLA 2.00E-75 GO:0006470; GO:0008138 protein dephosphorylation; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR020422; IPR024950; IPR000387; Serine/threonine/tyrosine-interacting protein A styx-a Xenopus laevis (African clawed frog) TR38074_c0_g1_i7 Q60969 STYX_MOUSE 3.00E-58 GO:0006470; GO:0008138 protein dephosphorylation; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR020422; IPR024950; IPR000387; Serine/threonine/tyrosine-interacting protein (Phosphoserine/threonine/tyrosine interaction protein) (Protein tyrosine phosphatase-like protein) Styx Mus musculus (Mouse) TR38075_c1_g1_i1 P38997 LYS1_YARLI 7.00E-06 GO:0019878; GO:0004754 "lysine biosynthetic process via aminoadipic acid; saccharopine dehydrogenase (NAD+, L-lysine-forming) activity" IPR007886; IPR007698; IPR027281; Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3. "Saccharopine dehydrogenase [NAD(+), L-lysine-forming] (SDH) (EC 1.5.1.7) (Lysine--2-oxoglutarate reductase)" LYS5 YALI0B15444g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR38075_c3_g1_i1 Q9UDR5 AASS_HUMAN 0 GO:0033512; GO:0034641; GO:0006554; GO:0005759; GO:0051262; GO:0047131; GO:0047130 "L-lysine catabolic process to acetyl-CoA via saccharopine; cellular nitrogen compound metabolic process; lysine catabolic process; mitochondrial matrix; protein tetramerization; saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity; saccharopine dehydrogenase (NADP+, L-lysine-forming) activity" IPR007886; IPR007698; IPR016040; IPR005097; Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6. Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6. "Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)]" AASS Homo sapiens (Human) TR38075_c3_g1_i2 Q9AJC6 LYSDH_GEOSE 1.00E-10 GO:0050303; GO:0051260 lysine 6-dehydrogenase activity; protein homooligomerization IPR016040; IPR005097; Lysine 6-dehydrogenase (EC 1.4.1.18) (L-lysine 6-dehydrogenase) (L-lysine epsilon-dehydrogenase) lysDH Geobacillus stearothermophilus (Bacillus stearothermophilus) TR38076_c4_g1_i1 Q9NX07 TSAP1_HUMAN 3.00E-59 GO:0003723; GO:0005737; GO:0000166; GO:0005634; GO:0001514 RNA binding; cytoplasm; nucleotide binding; nucleus; selenocysteine incorporation IPR012677; IPR000504; tRNA selenocysteine 1-associated protein 1 (SECp43) (tRNA selenocysteine-associated protein 1) TRNAU1AP SECP43 TRSPAP1 Homo sapiens (Human) TR38076_c6_g5_i1 Q8K385 FRRS1_MOUSE 3.00E-36 GO:0000293; GO:0016021; GO:0046872 ferric-chelate reductase activity; integral to membrane; metal ion binding IPR006593; IPR005018; IPR002861; Ferric-chelate reductase 1 (EC 1.-.-.-) (Stromal cell-derived receptor 2) (SDR-2) FRRS1 Sdfr2 Sdr2 Mus musculus (Mouse) TR38077_c1_g1_i1 Q6CA79 AMPM2_YARLI 1.00E-147 GO:0004177; GO:0009987; GO:0005737; GO:0046872; GO:0008235; GO:0006508 aminopeptidase activity; cellular process; cytoplasm; metal ion binding; metalloexopeptidase activity; proteolysis IPR001714; IPR000994; IPR002468; IPR018349; IPR011991; Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Peptidase M) MAP2 YALI0D05159g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR38077_c1_g1_i2 C5DE35 AMPM2_LACTC 2.00E-136 GO:0004177; GO:0009987; GO:0005737; GO:0046872; GO:0008235; GO:0006508 aminopeptidase activity; cellular process; cytoplasm; metal ion binding; metalloexopeptidase activity; proteolysis IPR001714; IPR000994; IPR002468; IPR018349; IPR011991; Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Peptidase M) MAP2 KLTH0C05962g Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans) TR38077_c1_g1_i3 Q3ZC89 AMPM2_BOVIN 0 GO:0004177; GO:0009987; GO:0005737; GO:0046872; GO:0008235; GO:0006508 aminopeptidase activity; cellular process; cytoplasm; metal ion binding; metalloexopeptidase activity; proteolysis IPR001714; IPR000994; IPR002468; IPR018349; IPR011991; Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) METAP2 Bos taurus (Bovine) TR38077_c1_g1_i4 C4R2P3 AMPM2_PICPG 8.00E-149 GO:0004177; GO:0009987; GO:0005737; GO:0046872; GO:0008235; GO:0006508 aminopeptidase activity; cellular process; cytoplasm; metal ion binding; metalloexopeptidase activity; proteolysis IPR001714; IPR000994; IPR002468; IPR018349; IPR011991; Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Peptidase M) MAP2 PAS_chr2-2_0159 Komagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris) TR38077_c1_g1_i5 Q3ZC89 AMPM2_BOVIN 0 GO:0004177; GO:0009987; GO:0005737; GO:0046872; GO:0008235; GO:0006508 aminopeptidase activity; cellular process; cytoplasm; metal ion binding; metalloexopeptidase activity; proteolysis IPR001714; IPR000994; IPR002468; IPR018349; IPR011991; Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) METAP2 Bos taurus (Bovine) TR38077_c1_g1_i6 P22624 AMPM_METFE 9.00E-14 GO:0004177; GO:0009987; GO:0046872; GO:0008235; GO:0006508 aminopeptidase activity; cellular process; metal ion binding; metalloexopeptidase activity; proteolysis IPR001714; IPR000994; IPR018349; Methionine aminopeptidase (MAP) (MetAP) (EC 3.4.11.18) (Peptidase M) (Fragment) map Methanothermus fervidus TR38079_c0_g1_i1 Q9JLV2 TP4AP_MOUSE 4.00E-146 GO:0031464; GO:0019902; GO:0016567; GO:0006511 Cul4A-RING ubiquitin ligase complex; phosphatase binding; protein ubiquitination; ubiquitin-dependent protein catabolic process IPR016024; IPR022162; Protein modification; protein ubiquitination. Short transient receptor potential channel 4-associated protein (Trp4-associated protein) (Trpc4-associated protein) (Protein TAP1) (Rabex-5/Rin2-interacting protein) (TNF-receptor ubiquitous scaffolding/signaling protein) (Protein TRUSS) Trpc4ap Trrp4ap Mus musculus (Mouse) TR38079_c0_g1_i3 Q9JLV2 TP4AP_MOUSE 4.00E-36 GO:0031464; GO:0019902; GO:0016567; GO:0006511 Cul4A-RING ubiquitin ligase complex; phosphatase binding; protein ubiquitination; ubiquitin-dependent protein catabolic process IPR016024; IPR022162; Protein modification; protein ubiquitination. Short transient receptor potential channel 4-associated protein (Trp4-associated protein) (Trpc4-associated protein) (Protein TAP1) (Rabex-5/Rin2-interacting protein) (TNF-receptor ubiquitous scaffolding/signaling protein) (Protein TRUSS) Trpc4ap Trrp4ap Mus musculus (Mouse) TR3808_c1_g1_i1 Q9P2E3 ZNFX1_HUMAN 2.00E-10 GO:0046872 metal ion binding IPR016024; IPR027417; NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) TR38080_c0_g1_i1 P14211 CALR_MOUSE 2.00E-103 GO:0005794; GO:0042824; GO:0001669; GO:0005509; GO:0030246; GO:0055007; GO:0007050; GO:0071285; GO:0071310; GO:0090398; GO:0030866; GO:0005829; GO:0005788; GO:0009897; GO:0031012; GO:0005615; GO:0042562; GO:0005506; GO:0003729; GO:0033144; GO:0045665; GO:0048387; GO:0000122; GO:0017148; GO:0005634; GO:0002502; GO:0042277; GO:0048471; GO:0045335; GO:0005844; GO:0045740; GO:0045787; GO:0008284; GO:2000510; GO:0010628; GO:0050766; GO:1900026; GO:0006611; GO:0006457; GO:0034504; GO:0050821; GO:0040020; GO:0042493; GO:0032355; GO:0033574; GO:0033018; GO:0007283 Golgi apparatus; MHC class I peptide loading complex; acrosomal vesicle; calcium ion binding; carbohydrate binding; cardiac muscle cell differentiation; cell cycle arrest; cellular response to lithium ion; cellular response to organic substance; cellular senescence; cortical actin cytoskeleton organization; cytosol; endoplasmic reticulum lumen; external side of plasma membrane; extracellular matrix; extracellular space; hormone binding; iron ion binding; mRNA binding; negative regulation of intracellular steroid hormone receptor signaling pathway; negative regulation of neuron differentiation; negative regulation of retinoic acid receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of translation; nucleus; peptide antigen assembly with MHC class I protein complex; peptide binding; perinuclear region of cytoplasm; phagocytic vesicle; polysome; positive regulation of DNA replication; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of dendritic cell chemotaxis; positive regulation of gene expression; positive regulation of phagocytosis; positive regulation of substrate adhesion-dependent cell spreading; protein export from nucleus; protein folding; protein localization to nucleus; protein stabilization; regulation of meiosis; response to drug; response to estradiol stimulus; response to testosterone stimulus; sarcoplasmic reticulum lumen; spermatogenesis IPR001580; IPR018124; IPR009169; IPR009033; IPR008985; IPR013320; Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) Calr Mus musculus (Mouse) TR38081_c1_g1_i1 H2A0M3 AMO_PINMG 8.00E-29 GO:0009308; GO:0005507; GO:0005576; GO:0008131; GO:0048038 amine metabolic process; copper ion binding; extracellular region; primary amine oxidase activity; quinone binding IPR000269; IPR015798; IPR016182; IPR015801; Putative amine oxidase [copper-containing] (EC 1.4.3.-) Pinctada margaritifera (Black-lipped pearl oyster) TR38081_c4_g1_i1 Q8WZ42 TITIN_HUMAN 4.00E-06 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR38081_c6_g1_i1 Q9QZS7 NPHN_MOUSE 3.00E-07 GO:0007254; GO:0007155; GO:0042995; GO:0032836; GO:0072015; GO:0005887; GO:0007520; GO:0030838; GO:0044062; GO:0007519; GO:0036057 JNK cascade; cell adhesion; cell projection; glomerular basement membrane development; glomerular visceral epithelial cell development; integral to plasma membrane; myoblast fusion; positive regulation of actin filament polymerization; regulation of excretion; skeletal muscle tissue development; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Mus musculus (Mouse) TR38084_c1_g3_i1 Q5R5Z5 ARPC2_PONAB 5.00E-163 GO:0005794; GO:0031252; GO:0042995; GO:0005856; GO:0005768; GO:0005925; GO:0005886; GO:0030838; GO:1900026 Golgi apparatus; cell leading edge; cell projection; cytoskeleton; endosome; focal adhesion; plasma membrane; positive regulation of actin filament polymerization; positive regulation of substrate adhesion-dependent cell spreading IPR007188; Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC) ARPC2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38085_c2_g1_i1 A3KPP4 S2535_DANRE 2.00E-105 GO:0016021; GO:0005743; GO:0006810 integral to membrane; mitochondrial inner membrane; transport IPR018108; IPR023395; Solute carrier family 25 member 35 slc25a35 si:ch211-268m12.5 Danio rerio (Zebrafish) (Brachydanio rerio) TR38085_c2_g1_i4 Q76PC3 YQ73_SCHPO 1.00E-09 GO:0016021; GO:0005743; GO:0006839; GO:0022857 integral to membrane; mitochondrial inner membrane; mitochondrial transport; transmembrane transporter activity IPR018108; IPR023395; Uncharacterized mitochondrial carrier C1442.03 SPCC1442.03 SPCC1450.19 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38085_c3_g3_i4 Q68EL6 NFIL3_DANRE 4.00E-06 GO:0007623; GO:0005737; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "circadian rhythm; cytoplasm; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; IPR016743; IPR010533; Nuclear factor interleukin-3-regulated protein nfil3 Danio rerio (Zebrafish) (Brachydanio rerio) TR38086_c4_g1_i1 Q9XWN6 ANI3_CAEEL 5.00E-06 GO:0005543 phospholipid binding IPR012966; IPR011993; IPR001849; Anillin-like protein 3 ani-3 Y43F8C.14 Caenorhabditis elegans TR38086_c4_g1_i2 Q6V7V2 RTKN_RAT 2.00E-87 GO:0005525; GO:0017049; GO:0005095; GO:0007266; GO:0006915; GO:0005543 GTP binding; GTP-Rho binding; GTPase inhibitor activity; Rho protein signal transduction; apoptotic process; phospholipid binding IPR012966; IPR011072; IPR001849; Rhotekin Rtkn Rattus norvegicus (Rat) TR38086_c4_g2_i1 Q6V7V2 RTKN_RAT 3.00E-87 GO:0005525; GO:0017049; GO:0005095; GO:0007266; GO:0006915; GO:0005543 GTP binding; GTP-Rho binding; GTPase inhibitor activity; Rho protein signal transduction; apoptotic process; phospholipid binding IPR012966; IPR011072; IPR001849; Rhotekin Rtkn Rattus norvegicus (Rat) TR38086_c4_g2_i2 Q9XWN6 ANI3_CAEEL 5.00E-06 GO:0005543 phospholipid binding IPR012966; IPR011993; IPR001849; Anillin-like protein 3 ani-3 Y43F8C.14 Caenorhabditis elegans TR38087_c2_g1_i1 Q28C44 C19L2_XENTR 8.00E-138 GO:0003824; GO:0008152 catalytic activity; metabolic process IPR006768; IPR006767; IPR011146; CWF19-like protein 2 cwf19l2 TEgg088d19.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38087_c3_g1_i1 Q3LSS0 C19L2_DANRE 1.00E-27 GO:0003824; GO:0008152 catalytic activity; metabolic process IPR006768; IPR006767; IPR011146; CWF19-like protein 2 cwf19l2 Danio rerio (Zebrafish) (Brachydanio rerio) TR38089_c3_g1_i1 Q96P48 ARAP1_HUMAN 1.00E-28 GO:0008060; GO:0005794; GO:0032580; GO:0005100; GO:0030037; GO:0005829; GO:0051497; GO:0005547; GO:0005886; GO:0043089; GO:0051491; GO:0032312; GO:0008360; GO:0051270; GO:0007264; GO:0008270 O00220; P12956 "ARF GTPase activator activity; Golgi apparatus; Golgi cisterna membrane; Rho GTPase activator activity; actin filament reorganization involved in cell cycle; cytosol; negative regulation of stress fiber assembly; phosphatidylinositol-3,4,5-trisphosphate binding; plasma membrane; positive regulation of Cdc42 GTPase activity; positive regulation of filopodium assembly; regulation of ARF GTPase activity; regulation of cell shape; regulation of cellular component movement; small GTPase mediated signal transduction; zinc ion binding" IPR001164; IPR011993; IPR001849; IPR000159; IPR008936; IPR000198; IPR001660; IPR013761; IPR021129; "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)" ARAP1 CENTD2 KIAA0782 Homo sapiens (Human) TR38089_c3_g1_i2 Q8WZ64 ARAP2_HUMAN 2.00E-31 GO:0008060; GO:0005829; GO:0005547; GO:0043547; GO:0032312; GO:0051056; GO:0007264; GO:0008270 "ARF GTPase activator activity; cytosol; phosphatidylinositol-3,4,5-trisphosphate binding; positive regulation of GTPase activity; regulation of ARF GTPase activity; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; zinc ion binding" IPR001164; IPR011993; IPR001849; IPR000159; IPR008936; IPR000198; IPR001660; IPR013761; IPR021129; "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (Centaurin-delta-1) (Cnt-d1) (Protein PARX)" ARAP2 CENTD1 KIAA0580 Homo sapiens (Human) TR38089_c4_g1_i1 Q8IVE3 PKHH2_HUMAN 3.00E-07 GO:0003779; GO:0030864; GO:0030027; GO:0030835; GO:0005543; GO:0005886 actin binding; cortical actin cytoskeleton; lamellipodium; negative regulation of actin filament depolymerization; phospholipid binding; plasma membrane IPR019749; IPR014352; IPR019748; IPR000299; IPR000857; IPR011993; IPR001849; Pleckstrin homology domain-containing family H member 2 PLEKHH2 KIAA2028 Homo sapiens (Human) TR38089_c5_g4_i1 A2RUV4 RHG21_XENTR 2.00E-24 GO:0005096; GO:0000139; GO:0030054; GO:0030659; GO:0005856; GO:0005543; GO:0043547; GO:0007165 GTPase activator activity; Golgi membrane; cell junction; cytoplasmic vesicle membrane; cytoskeleton; phospholipid binding; positive regulation of GTPase activity; signal transduction IPR001478; IPR011993; IPR001849; IPR008936; IPR000198; Rho GTPase-activating protein 21 (Rho-type GTPase-activating protein 21) arhgap21 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38089_c5_g4_i3 Q96P48 ARAP1_HUMAN 1.00E-40 GO:0008060; GO:0005794; GO:0032580; GO:0005100; GO:0030037; GO:0005829; GO:0051497; GO:0005547; GO:0005886; GO:0043089; GO:0051491; GO:0032312; GO:0008360; GO:0051270; GO:0007264; GO:0008270 O00220; P12956 "ARF GTPase activator activity; Golgi apparatus; Golgi cisterna membrane; Rho GTPase activator activity; actin filament reorganization involved in cell cycle; cytosol; negative regulation of stress fiber assembly; phosphatidylinositol-3,4,5-trisphosphate binding; plasma membrane; positive regulation of Cdc42 GTPase activity; positive regulation of filopodium assembly; regulation of ARF GTPase activity; regulation of cell shape; regulation of cellular component movement; small GTPase mediated signal transduction; zinc ion binding" IPR001164; IPR011993; IPR001849; IPR000159; IPR008936; IPR000198; IPR001660; IPR013761; IPR021129; "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)" ARAP1 CENTD2 KIAA0782 Homo sapiens (Human) TR38092_c5_g1_i1 Q9D753 EXOS8_MOUSE 1.00E-107 GO:0017091; GO:0005737; GO:0000178; GO:0005730; GO:0006364 AU-rich element binding; cytoplasm; exosome (RNase complex); nucleolus; rRNA processing IPR001247; IPR015847; IPR027408; IPR020568; Exosome complex component RRP43 (Exosome component 8) (Ribosomal RNA-processing protein 43) Exosc8 Rrp43 Mus musculus (Mouse) TR38092_c5_g1_i2 Q96B26 EXOS8_HUMAN 6.00E-109 GO:0017091; GO:0005829; GO:0043928; GO:0000178; GO:0010467; GO:0005730; GO:0005634; GO:0006364 Q9NQT5; Q9NQT4 AU-rich element binding; cytosol; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; exosome (RNase complex); gene expression; nucleolus; nucleus; rRNA processing IPR001247; IPR015847; IPR027408; IPR020568; Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9) EXOSC8 OIP2 RRP43 Homo sapiens (Human) TR38092_c6_g1_i2 Q8BG81 PDIP3_MOUSE 4.00E-20 GO:0003723; GO:0005737; GO:0035145; GO:0016607; GO:0000166; GO:0045727 RNA binding; cytoplasm; exon-exon junction complex; nuclear speck; nucleotide binding; positive regulation of translation IPR012677; IPR000504; Polymerase delta-interacting protein 3 (S6K1 Aly/REF-like target) (SKAR) Poldip3 Mus musculus (Mouse) TR38092_c6_g1_i5 Q8BG81 PDIP3_MOUSE 5.00E-20 GO:0003723; GO:0005737; GO:0035145; GO:0016607; GO:0000166; GO:0045727 RNA binding; cytoplasm; exon-exon junction complex; nuclear speck; nucleotide binding; positive regulation of translation IPR012677; IPR000504; Polymerase delta-interacting protein 3 (S6K1 Aly/REF-like target) (SKAR) Poldip3 Mus musculus (Mouse) TR38094_c1_g4_i1 P56276 MYLK_MELGA 2.00E-16 IPR007110; IPR013783; IPR013098; IPR003598; IPR020675; Telokin Meleagris gallopavo (Common turkey) TR38095_c1_g2_i6 Q60949 TBCD1_MOUSE 3.00E-160 GO:0005097; GO:0005829; GO:0005634; GO:0032851 Rab GTPase activator activity; cytosol; nucleus; positive regulation of Rab GTPase activity IPR021785; IPR011993; IPR006020; IPR000195; TBC1 domain family member 1 Tbc1d1 Kiaa1108 Tbc1 Mus musculus (Mouse) TR38095_c1_g2_i9 Q60949 TBCD1_MOUSE 1.00E-161 GO:0005097; GO:0005829; GO:0005634; GO:0032851 Rab GTPase activator activity; cytosol; nucleus; positive regulation of Rab GTPase activity IPR021785; IPR011993; IPR006020; IPR000195; TBC1 domain family member 1 Tbc1d1 Kiaa1108 Tbc1 Mus musculus (Mouse) TR38097_c4_g2_i2 Q98943 CASP2_CHICK 2.00E-14 GO:0006915; GO:0004197; GO:0005622; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; intracellular; proteolysis; regulation of apoptotic process IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) TR38098_c0_g2_i1 Q8NI99 ANGL6_HUMAN 1.00E-31 GO:0001525; GO:0030154; GO:0005576; GO:0030141 angiogenesis; cell differentiation; extracellular region; secretory granule IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-related protein 6 (Angiopoietin-like protein 6) (Angiopoietin-related growth factor) (Angiopoietin-related protein 5) ANGPTL6 AGF ARP5 UNQ152/PRO178 Homo sapiens (Human) TR38098_c0_g2_i3 Q8R0Z6 ANGL6_MOUSE 3.00E-29 GO:0001525; GO:0030154; GO:0005576; GO:0030141 angiogenesis; cell differentiation; extracellular region; secretory granule IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-related protein 6 (Angiopoietin-like protein 6) (Angiopoietin-related growth factor) Angptl6 Agf Mus musculus (Mouse) TR38098_c0_g2_i4 Q8NI99 ANGL6_HUMAN 2.00E-31 GO:0001525; GO:0030154; GO:0005576; GO:0030141 angiogenesis; cell differentiation; extracellular region; secretory granule IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-related protein 6 (Angiopoietin-like protein 6) (Angiopoietin-related growth factor) (Angiopoietin-related protein 5) ANGPTL6 AGF ARP5 UNQ152/PRO178 Homo sapiens (Human) TR38100_c2_g3_i1 Q8R3C1 CB042_MOUSE 2.00E-102 IPR026049; Uncharacterized protein C2orf42 homolog Mus musculus (Mouse) TR38101_c2_g1_i1 Q8XNV1 SULF_CLOPE 3.00E-17 GO:0004065; GO:0046872 arylsulfatase activity; metal ion binding IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase (EC 3.1.6.1) (Cys-type sulfatase) CPE0231 Clostridium perfringens (strain 13 / Type A) TR38101_c2_g1_i2 Q08890 IDS_MOUSE 0 GO:0004423; GO:0005764; GO:0046872; GO:0008484 iduronate-2-sulfatase activity; lysosome; metal ion binding; sulfuric ester hydrolase activity IPR017849; IPR017850; IPR000917; IPR024607; Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) Ids Mus musculus (Mouse) TR38101_c2_g1_i3 P22304 IDS_HUMAN 5.00E-115 GO:0005975; GO:0030207; GO:0004423; GO:0043202; GO:0046872 carbohydrate metabolic process; chondroitin sulfate catabolic process; iduronate-2-sulfatase activity; lysosomal lumen; metal ion binding IPR017849; IPR017850; IPR000917; IPR024607; Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Cleaved into: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain] IDS SIDS Homo sapiens (Human) TR38101_c2_g1_i4 Q60HH5 ARSE_MACFA 3.00E-06 GO:0005795; GO:0046872; GO:0008484 Golgi stack; metal ion binding; sulfuric ester hydrolase activity IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase E (ASE) (EC 3.1.6.-) ARSE QtrA-14484 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38102_c2_g1_i1 B0VXE6 CG063_CALJA 0 IPR011989; IPR016024; Uncharacterized protein C7orf63 Callithrix jacchus (White-tufted-ear marmoset) TR38102_c2_g1_i3 B0VXE6 CG063_CALJA 0 IPR011989; IPR016024; Uncharacterized protein C7orf63 Callithrix jacchus (White-tufted-ear marmoset) TR38103_c0_g1_i1 Q91Z53 GRHPR_MOUSE 1.00E-100 GO:0051287; GO:0070402; GO:0005737; GO:0007588; GO:0008465; GO:0030267; GO:0016618; GO:0051259 NAD binding; NADPH binding; cytoplasm; excretion; glycerate dehydrogenase activity; glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; protein oligomerization IPR006139; IPR006140; IPR016040; Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81) Grhpr Glxr Mus musculus (Mouse) TR38103_c0_g1_i2 Q02961 YP113_YEAST 8.00E-07 GO:0048037; GO:0016616 "cofactor binding; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" IPR006140; IPR016040; Putative 2-hydroxyacid dehydrogenase YPL113C (EC 1.-.-.-) YPL113C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR38103_c0_g1_i3 A1RYE4 GYAR_THEPD 5.00E-60 GO:0051287; GO:0005737; GO:0047964 NAD binding; cytoplasm; glyoxylate reductase activity IPR006139; IPR006140; IPR023519; IPR016040; Glyoxylate reductase (EC 1.1.1.26) gyaR Tpen_0823 Thermofilum pendens (strain Hrk 5) TR38105_c0_g1_i1 Q9WV76 AP4B1_MOUSE 1.00E-100 GO:0005794; GO:0030131; GO:0006886; GO:0008565; GO:0005802; GO:0016192 Golgi apparatus; clathrin adaptor complex; intracellular protein transport; protein transporter activity; trans-Golgi network; vesicle-mediated transport IPR026739; IPR016342; IPR011989; IPR016024; IPR015151; IPR012295; IPR002553; AP-4 complex subunit beta-1 (AP-4 adapter complex subunit beta) (Adapter-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin) Ap4b1 Mus musculus (Mouse) TR38105_c0_g1_i3 Q32PG1 AP3B1_BOVIN 8.00E-13 GO:0030123; GO:0005794; GO:0008089; GO:0048490; GO:0048007; GO:0007596; GO:0030665; GO:0006897; GO:0032438; GO:0051138; GO:0006622 "AP-3 adaptor complex; Golgi apparatus; anterograde axon cargo transport; anterograde synaptic vesicle transport; antigen processing and presentation, exogenous lipid antigen via MHC class Ib; blood coagulation; clathrin-coated vesicle membrane; endocytosis; melanosome organization; positive regulation of NK T cell differentiation; protein targeting to lysosome" IPR026740; IPR026739; IPR011989; IPR016024; IPR002553; AP-3 complex subunit beta-1 (Adapter-related protein complex 3 subunit beta-1) (Adaptor protein complex AP-3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain) AP3B1 Bos taurus (Bovine) TR38108_c2_g2_i2 Q6NRD5 EXD1_XENLA 6.00E-20 GO:0008408; GO:0003676; GO:0090305 3'-5' exonuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis IPR002562; IPR012337; Exonuclease 3'-5' domain-containing protein 1 (Exonuclease 3'-5' domain-like-containing protein 1) exd1 exdl1 Xenopus laevis (African clawed frog) TR38108_c2_g2_i3 Q8CDF7 EXD1_MOUSE 4.00E-17 GO:0008408; GO:0003676; GO:0090305 3'-5' exonuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis IPR002562; IPR012337; Exonuclease 3'-5' domain-containing protein 1 (Exonuclease 3'-5' domain-like-containing protein 1) Exd1 Exdl1 Mus musculus (Mouse) TR38108_c2_g2_i5 Q12149 RRP6_YEAST 8.00E-06 GO:0000175; GO:0003723; GO:0034473; GO:0034475; GO:0034476; GO:0000467; GO:0071044; GO:0000176; GO:0071039; GO:0071040; GO:0071042; GO:0071035; GO:0071037; GO:0071036; GO:0071038; GO:0071049; GO:0005730; GO:0000166; GO:0071051; GO:0000973 "3'-5'-exoribonuclease activity; RNA binding; U1 snRNA 3'-end processing; U4 snRNA 3'-end processing; U5 snRNA 3'-end processing; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); histone mRNA catabolic process; nuclear exosome (RNase complex); nuclear polyadenylation-dependent CUT catabolic process; nuclear polyadenylation-dependent antisense transcript catabolic process; nuclear polyadenylation-dependent mRNA catabolic process; nuclear polyadenylation-dependent rRNA catabolic process; nuclear polyadenylation-dependent snRNA catabolic process; nuclear polyadenylation-dependent snoRNA catabolic process; nuclear polyadenylation-dependent tRNA catabolic process; nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription; nucleolus; nucleotide binding; polyadenylation-dependent snoRNA 3'-end processing; posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery" IPR002562; IPR012588; IPR010997; IPR002121; IPR012337; Exosome complex exonuclease RRP6 (EC 3.1.13.-) (Ribosomal RNA-processing protein 6) RRP6 UNC733 YOR001W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR38109_c1_g3_i1 Q01664 TFAP4_HUMAN 1.00E-31 GO:0006978; GO:0070888; GO:0003705; GO:0071549; GO:0043922; GO:0043392; GO:0043066; GO:0071157; GO:0008285; GO:0045736; GO:0045892; GO:0043923; GO:0043065; GO:0045893; GO:0006461; GO:0043565; GO:0017053 "DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; E-box binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; cellular response to dexamethasone stimulus; negative regulation by host of viral transcription; negative regulation of DNA binding; negative regulation of apoptotic process; negative regulation of cell cycle arrest; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of transcription, DNA-dependent; positive regulation by host of viral transcription; positive regulation of apoptotic process; positive regulation of transcription, DNA-dependent; protein complex assembly; sequence-specific DNA binding; transcriptional repressor complex" IPR011598; Transcription factor AP-4 (Activating enhancer-binding protein 4) (Class C basic helix-loop-helix protein 41) (bHLHc41) TFAP4 BHLHC41 Homo sapiens (Human) TR38112_c1_g1_i1 Q32LQ0 AMPE_BOVIN 0 GO:0016477; GO:0008283; GO:0016021; GO:0070006; GO:0006508; GO:0003081; GO:0008270 cell migration; cell proliferation; integral to membrane; metalloaminopeptidase activity; proteolysis; regulation of systemic arterial blood pressure by renin-angiotensin; zinc ion binding IPR024571; IPR001930; IPR014782; Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (CD antigen CD249) ENPEP Bos taurus (Bovine) TR38113_c0_g2_i1 P50163 TRN2_DATST 1.00E-13 GO:0009710; GO:0050358 tropane alkaloid biosynthetic process; tropinone reductase activity IPR002198; IPR002347; IPR016040; IPR020904; Alkaloid biosynthesis; tropane alkaloid biosynthesis. Tropinone reductase 2 (EC 1.1.1.236) (Tropinone reductase II) (TR-II) TR2 Datura stramonium (Jimsonweed) (Common thornapple) TR38113_c0_g2_i2 P55541 Y4LA_RHISN 3.00E-14 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Uncharacterized short-chain type dehydrogenase/reductase y4lA (EC 1.-.-.-) NGR_a02730 y4lA Rhizobium sp. (strain NGR234) TR38113_c0_g2_i3 Q93X68 FABG5_BRANA 2.00E-17 GO:0004316; GO:0051287; GO:0009507; GO:0006633 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NAD binding; chloroplast; fatty acid biosynthetic process IPR011284; IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. "3-oxoacyl-[acyl-carrier-protein] reductase 5, chloroplastic (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase 5) (Fragment)" bkr1 Brassica napus (Rape) TR38113_c0_g2_i5 Q96LJ7 DHRS1_HUMAN 2.00E-109 GO:0005783; GO:0005743; GO:0016491 endoplasmic reticulum; mitochondrial inner membrane; oxidoreductase activity IPR002198; IPR002347; IPR016040; Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-) DHRS1 Homo sapiens (Human) TR38113_c0_g2_i6 P71079 FABL_BACSU 2.00E-21 GO:0050661; GO:0004318; GO:0047117; GO:0030497; GO:0051289 "NADP binding; enoyl-[acyl-carrier-protein] reductase (NADH) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; fatty acid elongation; protein homotetramerization" IPR002198; IPR002347; IPR016040; Lipid metabolism; fatty acid biosynthesis. Enoyl-[acyl-carrier-protein] reductase [NADPH] FabL (ENR) (EC 1.3.1.104) (Enoyl-acyl carrier protein reductase III) (NADPH-dependent enoyl-ACP reductase) fabL yfhR ygaA BSU08650 Bacillus subtilis (strain 168) TR38113_c0_g2_i7 Q99L04 DHRS1_MOUSE 2.00E-113 GO:0005783; GO:0005743; GO:0016491 endoplasmic reticulum; mitochondrial inner membrane; oxidoreductase activity IPR002198; IPR002347; IPR016040; Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-) Dhrs1 D14ertd484e Mus musculus (Mouse) TR38113_c0_g2_i8 Q949M3 FABG3_BRANA 3.00E-17 GO:0004316; GO:0051287; GO:0009507; GO:0006633 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NAD binding; chloroplast; fatty acid biosynthetic process IPR011284; IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. "3-oxoacyl-[acyl-carrier-protein] reductase 3, chloroplastic (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase 3)" bkr3 Brassica napus (Rape) TR38115_c0_g1_i1 P36241 RL19_DROME 3.00E-61 GO:0051298; GO:0000022; GO:0005840; GO:0003735; GO:0006412 Q9VV60; Q9VUY2; Q9V444; Q24117 centrosome duplication; mitotic spindle elongation; ribosome; structural constituent of ribosome; translation IPR027547; IPR023638; IPR000196; IPR015972; IPR015974; 60S ribosomal protein L19 RpL19 M(2)60E CG2746 Drosophila melanogaster (Fruit fly) TR38116_c4_g1_i2 Q5RAK6 EST1A_PONAB 0 GO:0003677; GO:0000781; GO:0005829; GO:0004521; GO:0046872; GO:0000184; GO:0005730 "DNA binding; chromosome, telomeric region; cytosol; endoribonuclease activity; metal ion binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleolus" IPR018834; IPR019458; IPR002716; IPR011990; Telomerase-binding protein EST1A (EC 3.1.-.-) (EST1-like protein A) (Ever shorter telomeres 1A) (Smg-6 homolog) (Telomerase subunit EST1A) SMG6 EST1A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38116_c4_g2_i1 Q86US8 EST1A_HUMAN 2.00E-21 GO:0000781; GO:0005829; GO:0004521; GO:0010467; GO:0006406; GO:0046872; GO:0000184; GO:0005730; GO:0035303; GO:0005697; GO:0000723; GO:0042162 Q92900-2 "chromosome, telomeric region; cytosol; endoribonuclease activity; gene expression; mRNA export from nucleus; metal ion binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleolus; regulation of dephosphorylation; telomerase holoenzyme complex; telomere maintenance; telomeric DNA binding" IPR018834; IPR019458; IPR002716; IPR011990; Telomerase-binding protein EST1A (EC 3.1.-.-) (EST1-like protein A) (Ever shorter telomeres 1A) (Smg-6 homolog) (Telomerase subunit EST1A) (hSmg5/7a) SMG6 C17orf31 EST1A KIAA0732 Homo sapiens (Human) TR38116_c5_g1_i1 Q9BX95 SGPP1_HUMAN 2.00E-62 GO:0006915; GO:0005789; GO:0016021; GO:0044281; GO:0006668; GO:0030148; GO:0006670; GO:0042392 apoptotic process; endoplasmic reticulum membrane; integral to membrane; small molecule metabolic process; sphinganine-1-phosphate metabolic process; sphingolipid biosynthetic process; sphingosine metabolic process; sphingosine-1-phosphate phosphatase activity IPR000326; Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) SGPP1 Homo sapiens (Human) TR38119_c2_g2_i1 Q5RA60 INP4B_PONAB 1.00E-125 GO:0016316; GO:0036092; GO:0034597 "phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; phosphatidylinositol-3-phosphate biosynthetic process; phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity" IPR000008; Signal transduction; phosphatidylinositol signaling pathway. "Type II inositol 3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type II)" INPP4B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38119_c2_g2_i2 O15327 INP4B_HUMAN 3.00E-125 GO:0005794; GO:0006874; GO:0005829; GO:0043647; GO:0008289; GO:0045671; GO:0034594; GO:0016316; GO:0034597; GO:0046850; GO:0046822; GO:0051896; GO:0007165 "Golgi apparatus; cellular calcium ion homeostasis; cytosol; inositol phosphate metabolic process; lipid binding; negative regulation of osteoclast differentiation; phosphatidylinositol trisphosphate phosphatase activity; phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity; regulation of bone remodeling; regulation of nucleocytoplasmic transport; regulation of protein kinase B signaling cascade; signal transduction" IPR000008; Signal transduction; phosphatidylinositol signaling pathway. "Type II inositol 3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type II)" INPP4B Homo sapiens (Human) TR38119_c2_g2_i4 Q62784 INP4A_RAT 6.00E-95 GO:0016316; GO:0034597 "phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity" IPR000008; Signal transduction; phosphatidylinositol signaling pathway. "Type I inositol 3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type I)" Inpp4a Rattus norvegicus (Rat) TR38119_c2_g2_i6 Q5RA60 INP4B_PONAB 1.00E-125 GO:0016316; GO:0036092; GO:0034597 "phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; phosphatidylinositol-3-phosphate biosynthetic process; phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity" IPR000008; Signal transduction; phosphatidylinositol signaling pathway. "Type II inositol 3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type II)" INPP4B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38119_c2_g2_i7 Q62784 INP4A_RAT 7.00E-38 GO:0016316; GO:0034597 "phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity" IPR000008; Signal transduction; phosphatidylinositol signaling pathway. "Type I inositol 3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type I)" Inpp4a Rattus norvegicus (Rat) TR38120_c3_g2_i1 Q5YW75 ECTD_NOCFA 1.00E-12 GO:0016725 "oxidoreductase activity, acting on CH or CH2 groups" IPR012774; IPR008775; Ectoine hydroxylase (EC 1.17.-.-) ectD NFA_27190 Nocardia farcinica (strain IFM 10152) TR38120_c3_g3_i2 Q7RTX9 MOT14_HUMAN 3.00E-42 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR38123_c5_g4_i2 Q01063 PDE4D_MOUSE 0 GO:0004114; GO:0007568; GO:0030552; GO:0006198; GO:0034704; GO:0071872; GO:0071222; GO:0005737; GO:0008144; GO:0061028; GO:0046872; GO:0005815; GO:0035264; GO:0045822; GO:0033137; GO:1901898; GO:0030593; GO:0086004; GO:1901844; GO:0002027; GO:0010880; GO:0060314; GO:0007165; GO:0006939 P34971 "3',5'-cyclic-nucleotide phosphodiesterase activity; aging; cAMP binding; cAMP catabolic process; calcium channel complex; cellular response to epinephrine stimulus; cellular response to lipopolysaccharide; cytoplasm; drug binding; establishment of endothelial barrier; metal ion binding; microtubule organizing center; multicellular organism growth; negative regulation of heart contraction; negative regulation of peptidyl-serine phosphorylation; negative regulation of relaxation of cardiac muscle; neutrophil chemotaxis; regulation of cardiac muscle cell contraction; regulation of cell communication by electrical coupling involved in cardiac conduction; regulation of heart rate; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; regulation of ryanodine-sensitive calcium-release channel activity; signal transduction; smooth muscle contraction" IPR003607; IPR023088; IPR002073; IPR023174; "Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1." "cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.53) (DPDE3)" Pde4d Mus musculus (Mouse) TR38123_c5_g4_i3 Q8IRU4 PDE4E_DROME 0 GO:0004114; GO:0048675; GO:0048149; GO:0006198; GO:0019933; GO:0001661; GO:0007619; GO:0046331; GO:0045475; GO:0046872; GO:0046958; GO:0008355; GO:0048477; GO:0007614; GO:0007268; GO:0040040 "3',5'-cyclic-nucleotide phosphodiesterase activity; axon extension; behavioral response to ethanol; cAMP catabolic process; cAMP-mediated signaling; conditioned taste aversion; courtship behavior; lateral inhibition; locomotor rhythm; metal ion binding; nonassociative learning; olfactory learning; oogenesis; short-term memory; synaptic transmission; thermosensory behavior" IPR003607; IPR023088; IPR002073; IPR023174; "Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1." "cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F (EC 3.1.4.53) (Learning/memory process protein) (Protein dunce)" dnc CG32498 Drosophila melanogaster (Fruit fly) TR38123_c5_g4_i5 Q01063 PDE4D_MOUSE 0 GO:0004114; GO:0007568; GO:0030552; GO:0006198; GO:0034704; GO:0071872; GO:0071222; GO:0005737; GO:0008144; GO:0061028; GO:0046872; GO:0005815; GO:0035264; GO:0045822; GO:0033137; GO:1901898; GO:0030593; GO:0086004; GO:1901844; GO:0002027; GO:0010880; GO:0060314; GO:0007165; GO:0006939 P34971 "3',5'-cyclic-nucleotide phosphodiesterase activity; aging; cAMP binding; cAMP catabolic process; calcium channel complex; cellular response to epinephrine stimulus; cellular response to lipopolysaccharide; cytoplasm; drug binding; establishment of endothelial barrier; metal ion binding; microtubule organizing center; multicellular organism growth; negative regulation of heart contraction; negative regulation of peptidyl-serine phosphorylation; negative regulation of relaxation of cardiac muscle; neutrophil chemotaxis; regulation of cardiac muscle cell contraction; regulation of cell communication by electrical coupling involved in cardiac conduction; regulation of heart rate; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; regulation of ryanodine-sensitive calcium-release channel activity; signal transduction; smooth muscle contraction" IPR003607; IPR023088; IPR002073; IPR023174; "Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1." "cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.53) (DPDE3)" Pde4d Mus musculus (Mouse) TR38124_c7_g1_i2 Q8IVH4 MMAA_HUMAN 1.00E-149 GO:0005525; GO:0009236; GO:0009235; GO:0006635; GO:0005759; GO:0017111; GO:0019626 GTP binding; cobalamin biosynthetic process; cobalamin metabolic process; fatty acid beta-oxidation; mitochondrial matrix; nucleoside-triphosphatase activity; short-chain fatty acid catabolic process IPR003593; IPR005129; IPR027417; Cofactor biosynthesis; adenosylcobalamin biosynthesis. "Methylmalonic aciduria type A protein, mitochondrial (EC 3.6.-.-)" MMAA Homo sapiens (Human) TR38125_c0_g2_i1 Q5RAG8 P4HA1_PONAB 2.00E-06 GO:0031418; GO:0005788; GO:0005506; GO:0016702; GO:0004656 "L-ascorbic acid binding; endoplasmic reticulum lumen; iron ion binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; procollagen-proline 4-dioxygenase activity" IPR005123; IPR006620; IPR013547; IPR013026; IPR011990; IPR019734; "Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)" P4HA1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38125_c0_g3_i1 Q8BG58 P4HTM_MOUSE 5.00E-25 GO:0031418; GO:0005509; GO:0005789; GO:0016021; GO:0005506; GO:0016706 "L-ascorbic acid binding; calcium ion binding; endoplasmic reticulum membrane; integral to membrane; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" IPR011992; IPR018247; IPR005123; IPR006620; Transmembrane prolyl 4-hydroxylase (P4H-TM) (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 4) (HIF-PH4) (HIF-prolyl hydroxylase 4) (HPH-4) P4htm Ph4 Mus musculus (Mouse) TR38126_c0_g1_i1 Q9NBX4 RTXE_DROME 1.00E-07 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR38126_c2_g1_i1 Q924I2 M4K3_RAT 0 GO:0005524; GO:0007243; GO:0004674; GO:0009411; GO:0006950; GO:0005083 ATP binding; intracellular protein kinase cascade; protein serine/threonine kinase activity; response to UV; response to stress; small GTPase regulator activity IPR001180; IPR011009; IPR021160; IPR000719; IPR017441; IPR002290; Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) Map4k3 Rattus norvegicus (Rat) TR38126_c2_g1_i2 Q8IVH8 M4K3_HUMAN 1.00E-45 GO:0005524; GO:0007254; GO:0004674; GO:0009411; GO:0034612; GO:0005083 P62993; Q13094; Q04759; Q02111 ATP binding; JNK cascade; protein serine/threonine kinase activity; response to UV; response to tumor necrosis factor; small GTPase regulator activity IPR001180; IPR011009; IPR021160; IPR000719; IPR017441; IPR002290; Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) MAP4K3 RAB8IPL1 Homo sapiens (Human) TR38127_c1_g1_i1 Q5R561 FGOP2_PONAB 6.00E-62 GO:0005737 cytoplasm IPR008555; FGFR1 oncogene partner 2 homolog FGFR1OP2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38127_c1_g1_i2 O02197 CCA_SCHMA 2.00E-22 IPR008555; Circulating cathodic antigen (CCA) Schistosoma mansoni (Blood fluke) TR38127_c1_g1_i4 Q5FWT9 SIKE1_RAT 3.00E-43 GO:0005737 cytoplasm IPR008555; Suppressor of IKBKE 1 (Suppressor of IKK-epsilon) Sike1 Sike Rattus norvegicus (Rat) TR38127_c1_g1_i7 Q5ZKJ4 FGOP2_CHICK 9.00E-64 GO:0005737; GO:0042060 cytoplasm; wound healing IPR008555; FGFR1 oncogene partner 2 homolog FGFR1OP2 RCJMB04_10g7 Gallus gallus (Chicken) TR38128_c2_g1_i1 A9JTP3 BIRC7_XENTR 5.00E-10 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP) (Embryonic/Egg IAP) (EIAP/XLX) birc7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38128_c2_g1_i3 A9JTP3 BIRC7_XENTR 5.00E-10 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP) (Embryonic/Egg IAP) (EIAP/XLX) birc7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38130_c0_g1_i1 Q9CT10 RANB3_MOUSE 2.00E-37 GO:0005737; GO:0046907; GO:0005634; GO:0015031 cytoplasm; intracellular transport; nucleus; protein transport IPR011993; IPR000156; Ran-binding protein 3 (RanBP3) Ranbp3 Mus musculus (Mouse) TR38131_c3_g1_i5 P14198 AAC4_DICDI 1.00E-33 GO:0016021 integral to membrane AAC-rich mRNA clone AAC4 protein AAC4 DDB_G0267458 Dictyostelium discoideum (Slime mold) TR38132_c1_g5_i1 Q8JHV9 BIR7A_XENLA 2.00E-46 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR38132_c1_g5_i4 Q24307 IAP2_DROME 9.00E-19 GO:0050829; GO:0043066; GO:0043154; GO:0061057; GO:0006964; GO:0033160; GO:0070534; GO:0007423; GO:0008270 "defense response to Gram-negative bacterium; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; peptidoglycan recognition protein signaling pathway; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; positive regulation of protein import into nucleus, translocation; protein K63-linked ubiquitination; sensory organ development; zinc ion binding" IPR001370; IPR001841; IPR013083; Apoptosis 2 inhibitor (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) (dIAP2) Iap2 DIHA ILP CG8293 Drosophila melanogaster (Fruit fly) TR38132_c1_g5_i5 Q6TEM9 MYLIA_DANRE 4.00E-09 GO:0005737; GO:0005856; GO:0005829; GO:0007369; GO:0016874; GO:0030178; GO:0016567; GO:0008270 cytoplasm; cytoskeleton; cytosol; gastrulation; ligase activity; negative regulation of Wnt receptor signaling pathway; protein ubiquitination; zinc ion binding IPR019749; IPR019750; IPR014352; IPR019748; IPR000299; IPR018979; IPR011993; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MYLIP-A (EC 6.3.2.-) (Myosin regulatory light chain-interacting protein A) (MIR-A) mylipa mir mylip si:ch211-266j17.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR38132_c1_g5_i6 O08863 BIRC3_MOUSE 6.00E-37 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 P39429 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Inhibitor of apoptosis protein 1) (IAP-1) (mIAP-1) (mIAP1) Birc3 Birc2 Iap1 Mus musculus (Mouse) TR38132_c1_g5_i7 Q24306 IAP1_DROME 2.00E-31 GO:0019788; GO:0016055; GO:0048800; GO:0007298; GO:0008407; GO:0004869; GO:0005737; GO:0008354; GO:0097340; GO:1990001; GO:0043066; GO:0046673; GO:0005634; GO:0090263; GO:0031398; GO:0042787; GO:0045035; GO:0007289; GO:0004842; GO:0008270 P25843; Q86PE7; Q9XYF4; Q24475; Q24106 NEDD8 ligase activity; Wnt receptor signaling pathway; antennal morphogenesis; border follicle cell migration; chaeta morphogenesis; cysteine-type endopeptidase inhibitor activity; cytoplasm; germ cell migration; inhibition of cysteine-type endopeptidase activity; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of compound eye retinal cell programmed cell death; nucleus; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; sensory organ precursor cell division; spermatid nucleus differentiation; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; Apoptosis 1 inhibitor (EC 6.3.2.-) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (dIAP1) (Protein thread) th Iap1 CG12284 Drosophila melanogaster (Fruit fly) TR38133_c3_g1_i2 A2AJ76 HMCN2_MOUSE 1.00E-06 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 Hmcn2 Mus musculus (Mouse) TR38134_c6_g1_i4 P41971 ELK3_MOUSE 5.00E-38 GO:0003677; GO:0001525; GO:0005739; GO:0045892; GO:0005634; GO:0032422; GO:0003700; GO:0003714; GO:0006351; GO:0042060 "DNA binding; angiogenesis; mitochondrion; negative regulation of transcription, DNA-dependent; nucleus; purine-rich negative regulatory element binding; sequence-specific DNA binding transcription factor activity; transcription corepressor activity; transcription, DNA-dependent; wound healing" IPR000418; IPR011991; ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) Elk3 Erp Net Mus musculus (Mouse) TR38134_c6_g1_i6 P41971 ELK3_MOUSE 3.00E-38 GO:0003677; GO:0001525; GO:0005739; GO:0045892; GO:0005634; GO:0032422; GO:0003700; GO:0003714; GO:0006351; GO:0042060 "DNA binding; angiogenesis; mitochondrion; negative regulation of transcription, DNA-dependent; nucleus; purine-rich negative regulatory element binding; sequence-specific DNA binding transcription factor activity; transcription corepressor activity; transcription, DNA-dependent; wound healing" IPR000418; IPR011991; ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) Elk3 Erp Net Mus musculus (Mouse) TR38135_c2_g1_i1 P04755 ACH3_DROME 1.00E-104 GO:0004889; GO:0005892; GO:0030054; GO:0045211; GO:0007271 "acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; postsynaptic membrane; synaptic transmission, cholinergic" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit beta-like 1 nAcRbeta-64B Acr64B AcrD ard CG11348 Drosophila melanogaster (Fruit fly) TR38135_c4_g2_i2 Q27218 ACH7_CAEEL 3.00E-79 GO:0015464; GO:0004889; GO:0022848; GO:0030054; GO:0016021; GO:0043005; GO:0043025; GO:0045211; GO:0040012; GO:0046662 acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated cation channel activity; cell junction; integral to membrane; neuron projection; neuronal cell body; postsynaptic membrane; regulation of locomotion; regulation of oviposition IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit beta-type lev-1 (Levamisole-resistant protein 1) lev-1 F09E8.7 Caenorhabditis elegans TR38135_c4_g2_i3 P04755 ACH3_DROME 3.00E-114 GO:0004889; GO:0005892; GO:0030054; GO:0045211; GO:0007271 "acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; postsynaptic membrane; synaptic transmission, cholinergic" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit beta-like 1 nAcRbeta-64B Acr64B AcrD ard CG11348 Drosophila melanogaster (Fruit fly) TR38136_c0_g1_i1 P35604 COPZ1_BOVIN 3.00E-86 GO:0030126; GO:0006891; GO:0006886; GO:0006890 "COPI vesicle coat; intra-Golgi vesicle-mediated transport; intracellular protein transport; retrograde vesicle-mediated transport, Golgi to ER" IPR022775; IPR000804; IPR011012; Coatomer subunit zeta-1 (Zeta-1-coat protein) (Zeta-1 COP) COPZ1 COPZ Bos taurus (Bovine) TR38138_c3_g1_i1 O88831 KKCC2_RAT 5.00E-153 GO:0005524; GO:0032147; GO:0005509; GO:0004683; GO:0042995; GO:0005737; GO:0005634; GO:0046777; GO:0030295 ATP binding; activation of protein kinase activity; calcium ion binding; calmodulin-dependent protein kinase activity; cell projection; cytoplasm; nucleus; protein autophosphorylation; protein kinase activator activity IPR020636; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) Camkk2 Rattus norvegicus (Rat) TR38138_c3_g1_i3 Q8W490 PEPK2_ARATH 6.00E-31 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase PEPKR2 (EC 2.7.11.-) (Protein PHOSPHOENOLPYRUVATE CARBOXYLASE-RELATED KINASE 2) PEPKR2 At1g12680 T12C24.32 Arabidopsis thaliana (Mouse-ear cress) TR38138_c3_g2_i1 Q58588 Y1187_METJA 1.00E-08 GO:0016787 hydrolase activity IPR005502; Uncharacterized protein MJ1187 (EC 3.2.2.-) MJ1187 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR38138_c3_g2_i2 Q5UQA6 ADPRM_MIMIV 3.00E-07 GO:0016787 hydrolase activity IPR005502; Putative ADP-ribosyl glycohydrolase L543 (EC 3.2.2.-) MIMI_L543 Acanthamoeba polyphaga mimivirus (APMV) TR38138_c3_g2_i3 Q58588 Y1187_METJA 1.00E-10 GO:0016787 hydrolase activity IPR005502; Uncharacterized protein MJ1187 (EC 3.2.2.-) MJ1187 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR38138_c3_g2_i5 O28550 Y1724_ARCFU 3.00E-08 GO:0016787 hydrolase activity IPR005502; Uncharacterized protein AF_1724 (EC 3.2.2.-) AF_1724 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) TR38138_c3_g2_i9 P14300 DRAG_RHORU 2.00E-11 GO:0047407; GO:0009399; GO:0051725 ADP-ribosyl-[dinitrogen reductase] hydrolase activity; nitrogen fixation; protein de-ADP-ribosylation IPR013479; IPR005502; ADP-ribosyl-[dinitrogen reductase] glycohydrolase (ADP-ribosylglycohydrolase) (EC 3.2.2.24) (Dinitrogenase reductase-activating glycohydrolase) draG Rhodospirillum rubrum TR38138_c3_g4_i1 Q58588 Y1187_METJA 8.00E-08 GO:0016787 hydrolase activity IPR005502; Uncharacterized protein MJ1187 (EC 3.2.2.-) MJ1187 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR38140_c0_g1_i1 Q5ZKQ7 GID8_CHICK 4.00E-51 GO:0005634 nucleus IPR013144; IPR024964; IPR006595; IPR006594; IPR013720; Glucose-induced degradation protein 8 homolog GID8 RCJMB04_9k15 Gallus gallus (Chicken) TR38140_c0_g3_i2 A7SWD3 GID8_NEMVE 1.00E-44 GO:0005634 nucleus IPR013144; IPR024964; IPR006595; IPR006594; IPR013720; Glucose-induced degradation protein 8 homolog v1g247787 Nematostella vectensis (Starlet sea anemone) TR38141_c0_g2_i1 Q5FYB0 ARSJ_HUMAN 1.00E-161 GO:0004065; GO:0005788; GO:0005576; GO:0006687; GO:0046872; GO:0043687; GO:0044281 arylsulfatase activity; endoplasmic reticulum lumen; extracellular region; glycosphingolipid metabolic process; metal ion binding; post-translational protein modification; small molecule metabolic process IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase J (ASJ) (EC 3.1.6.-) ARSJ UNQ372/PRO708 Homo sapiens (Human) TR38141_c0_g2_i2 P33727 ARSB_FELCA 2.00E-173 GO:0003943; GO:0005764; GO:0046872 N-acetylgalactosamine-4-sulfatase activity; lysosome; metal ion binding IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) ARSB Felis catus (Cat) (Felis silvestris catus) TR38142_c1_g1_i1 Q5RFM7 TRM2_PONAB 9.00E-84 GO:0030697 S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity IPR025714; IPR025823; tRNA (uracil(54)-C(5))-methyltransferase homolog (EC 2.1.1.35) (TRM2 homolog) TRMT2B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38142_c1_g1_i2 Q5RFM7 TRM2_PONAB 3.00E-83 GO:0030697 S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity IPR025714; IPR025823; tRNA (uracil(54)-C(5))-methyltransferase homolog (EC 2.1.1.35) (TRM2 homolog) TRMT2B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38143_c4_g1_i11 P91958 TPM_MYTGA 4.00E-128 IPR000533; Tropomyosin Mytilus galloprovincialis (Mediterranean mussel) TR38143_c4_g1_i2 P91958 TPM_MYTGA 1.00E-143 IPR000533; Tropomyosin Mytilus galloprovincialis (Mediterranean mussel) TR38145_c1_g1_i1 Q9Z0Z4 HEPH_MOUSE 4.00E-85 GO:0006879; GO:0005507; GO:0006825; GO:0016021; GO:0006826; GO:0016491; GO:0048471; GO:0005886 cellular iron ion homeostasis; copper ion binding; copper ion transport; integral to membrane; iron ion transport; oxidoreductase activity; perinuclear region of cytoplasm; plasma membrane IPR011706; IPR011707; IPR002355; IPR008972; IPR027154; Hephaestin (EC 1.-.-.-) Heph Kiaa0698 Mus musculus (Mouse) TR38145_c1_g1_i2 P12263 FA8_PIG 4.00E-61 GO:0006953; GO:0007596; GO:0007155; GO:0005507; GO:0005615; GO:0016491 acute-phase response; blood coagulation; cell adhesion; copper ion binding; extracellular space; oxidoreductase activity IPR000421; IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; IPR008979; Coagulation factor VIII (Procoagulant component) F8 CF8 Sus scrofa (Pig) TR38145_c1_g1_i3 Q12542 LAC2_AGABI 7.00E-07 GO:0005507; GO:0005576; GO:0052716; GO:0046274 copper ion binding; extracellular region; hydroquinone:oxygen oxidoreductase activity; lignin catabolic process IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; Laccase-2 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 2) (Diphenol oxidase 2) (Laccase II) (Urishiol oxidase 2) lcc2 Agaricus bisporus (White button mushroom) TR38146_c4_g2_i2 Q5FZI9 URIC_CANFA 6.00E-96 GO:0005777; GO:0006144; GO:0019628; GO:0004846 peroxisome; purine nucleobase metabolic process; urate catabolic process; urate oxidase activity IPR002042; IPR019842; Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3. Uricase (EC 1.7.3.3) (Urate oxidase) UOX Canis familiaris (Dog) (Canis lupus familiaris) TR38146_c4_g2_i4 Q3MHG7 URIC_BOVIN 5.00E-97 GO:0005739; GO:0005777; GO:0006144; GO:0019628; GO:0004846 mitochondrion; peroxisome; purine nucleobase metabolic process; urate catabolic process; urate oxidase activity IPR002042; IPR019842; Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3. Uricase (EC 1.7.3.3) (Urate oxidase) UOX Bos taurus (Bovine) TR38147_c2_g2_i1 Q4R628 KIF3A_MACFA 2.00E-147 GO:0005524; GO:0042384; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0007018; GO:0072372 ATP binding; cilium assembly; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement; primary cilium IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A) KIF3A QtsA-19288 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38148_c2_g1_i4 Q8VHI6 WASF3_MOUSE 2.00E-44 GO:0030036; GO:0005737; GO:0005856; GO:0007010; GO:0030027; GO:0030032; GO:0014003; GO:0031643; GO:0008360 actin cytoskeleton organization; cytoplasm; cytoskeleton; cytoskeleton organization; lamellipodium; lamellipodium assembly; oligodendrocyte development; positive regulation of myelination; regulation of cell shape IPR028288; IPR003124; Wiskott-Aldrich syndrome protein family member 3 (WASP family protein member 3) (Protein WAVE-3) Wasf3 Wave3 Mus musculus (Mouse) TR38149_c1_g1_i1 Q96MM6 HS12B_HUMAN 3.00E-102 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR38149_c1_g1_i3 P49118 BIP_SOLLC 4.00E-14 GO:0005524; GO:0005788 ATP binding; endoplasmic reticulum lumen IPR018181; IPR013126; Luminal-binding protein (BiP) (78 kDa glucose-regulated protein homolog) (GRP-78) Solanum lycopersicum (Tomato) (Lycopersicon esculentum) TR38149_c1_g1_i8 Q96MM6 HS12B_HUMAN 1.00E-100 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR38153_c1_g1_i3 O44252 ROST_DROME 3.00E-17 GO:0016021; GO:0016020; GO:0007520; GO:0007519 integral to membrane; membrane; myoblast fusion; skeletal muscle tissue development IPR006838; Protein rolling stone rost CG9552 Drosophila melanogaster (Fruit fly) TR38153_c2_g1_i1 O75771 RA51D_HUMAN 6.00E-30 GO:0005524; GO:0003677; GO:0006281; GO:0008094; GO:0005634; GO:0007131 Q6NVH7; O43543 ATP binding; DNA binding; DNA repair; DNA-dependent ATPase activity; nucleus; reciprocal meiotic recombination IPR003593; IPR013632; IPR016467; IPR020588; IPR027417; DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) (TRAD) RAD51D RAD51L3 Homo sapiens (Human) TR38153_c2_g1_i3 A5UKT8 RADB_METS3 3.00E-07 GO:0005524; GO:0006310; GO:0006281; GO:0008094; GO:0003684 ATP binding; DNA recombination; DNA repair; DNA-dependent ATPase activity; damaged DNA binding IPR003593; IPR013632; IPR020588; IPR011939; IPR004504; IPR027417; DNA repair and recombination protein RadB radB Msm_0611 Methanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861) TR38153_c2_g1_i6 Q12U80 RADB_METBU 8.00E-07 GO:0005524; GO:0006310; GO:0006281; GO:0008094; GO:0003684 ATP binding; DNA recombination; DNA repair; DNA-dependent ATPase activity; damaged DNA binding IPR003593; IPR013632; IPR020588; IPR011939; IPR004504; IPR027417; DNA repair and recombination protein RadB radB Mbur_2123 Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) TR38153_c3_g1_i1 O55230 RA51D_MOUSE 5.00E-29 GO:0005524; GO:0003677; GO:0006310; GO:0006281; GO:0008094; GO:0005634 ATP binding; DNA binding; DNA recombination; DNA repair; DNA-dependent ATPase activity; nucleus IPR003593; IPR013632; IPR016467; IPR020588; IPR027417; DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) Rad51d R51h3 Rad51l3 Mus musculus (Mouse) TR38153_c3_g1_i2 O35719 RA51B_MOUSE 8.00E-07 GO:0005524; GO:0003677; GO:0006310; GO:0006281; GO:0008094; GO:0005634 ATP binding; DNA binding; DNA recombination; DNA repair; DNA-dependent ATPase activity; nucleus IPR003593; IPR013632; IPR016467; IPR020588; IPR027417; DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (RAD51-like protein 1) Rad51b Rad51l1 Rec2 Mus musculus (Mouse) TR38153_c3_g2_i1 O55230 RA51D_MOUSE 6.00E-24 GO:0005524; GO:0003677; GO:0006310; GO:0006281; GO:0008094; GO:0005634 ATP binding; DNA binding; DNA recombination; DNA repair; DNA-dependent ATPase activity; nucleus IPR003593; IPR013632; IPR016467; IPR020588; IPR027417; DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) Rad51d R51h3 Rad51l3 Mus musculus (Mouse) TR38154_c0_g1_i5 Q5RCC0 TM2D2_PONAB 1.00E-50 GO:0016021 integral to membrane IPR007829; TM2 domain-containing protein 2 TM2D2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38155_c0_g3_i1 B0WEV5 ASNA_CULQU 2.00E-168 GO:0005524; GO:0006200; GO:0016887; GO:0005783; GO:0046872; GO:0045048; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; endoplasmic reticulum; metal ion binding; protein insertion into ER membrane; transport IPR025723; IPR016300; IPR027542; IPR027417; ATPase ASNA1 homolog (EC 3.6.-.-) (Arsenical pump-driving ATPase homolog) (Arsenite-stimulated ATPase) CPIJ005690 Culex quinquefasciatus (Southern house mosquito) (Culex pungens) TR38155_c0_g3_i2 A7RQM5 ASNA_NEMVE 9.00E-158 GO:0005524; GO:0006200; GO:0016887; GO:0005783; GO:0046872; GO:0045048; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; endoplasmic reticulum; metal ion binding; protein insertion into ER membrane; transport IPR025723; IPR016300; IPR027542; IPR027417; ATPase ASNA1 homolog (EC 3.6.-.-) (Arsenical pump-driving ATPase homolog) (Arsenite-stimulated ATPase) v1g161623 Nematostella vectensis (Starlet sea anemone) TR38156_c0_g2_i1 Q9WUU7 CATZ_MOUSE 2.00E-137 GO:0008234; GO:0005783; GO:0060441; GO:0005615; GO:0005764; GO:0006508 cysteine-type peptidase activity; endoplasmic reticulum; epithelial tube branching involved in lung morphogenesis; extracellular space; lysosome; proteolysis IPR025661; IPR013128; IPR000668; Cathepsin Z (EC 3.4.18.1) Ctsz Mus musculus (Mouse) TR38156_c0_g4_i1 P05689 CATZ_BOVIN 6.00E-51 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR013128; IPR000668; Cathepsin Z (EC 3.4.18.1) CTSZ Bos taurus (Bovine) TR38156_c0_g4_i4 Q9UBR2 CATZ_HUMAN 2.00E-50 GO:0002003; GO:0044267; GO:0008234; GO:0005783; GO:0060441; GO:0005615; GO:0005764; GO:0005886; GO:0006508 angiotensin maturation; cellular protein metabolic process; cysteine-type peptidase activity; endoplasmic reticulum; epithelial tube branching involved in lung morphogenesis; extracellular space; lysosome; plasma membrane; proteolysis IPR025661; IPR013128; IPR000668; Cathepsin Z (EC 3.4.18.1) (Cathepsin P) (Cathepsin X) CTSZ Homo sapiens (Human) TR38157_c1_g2_i2 A6TFG7 GHRB_KLEP7 3.00E-27 GO:0051287; GO:0005737; GO:0030267; GO:0016618; GO:0005886 NAD binding; cytoplasm; glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; plasma membrane IPR006139; IPR006140; IPR023756; IPR016040; Glyoxylate/hydroxypyruvate reductase B (EC 1.1.1.79) (EC 1.1.1.81) ghrB KPN78578_38770 KPN_03915 Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) TR38157_c1_g2_i3 Q2VEQ7 DDH_HALMT 1.00E-28 GO:0070404; GO:0070402; GO:0031406; GO:0019752; GO:0016616 "NADH binding; NADPH binding; carboxylic acid binding; carboxylic acid metabolic process; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" IPR006140; IPR016040; D-2-hydroxyacid dehydrogenase (D2-HDH) (EC 1.1.1.-) (D-specific 2-hydroxyacid dehydrogenase) ddh serA5 HFX_2024 Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) (Halobacterium mediterranei) TR38157_c1_g2_i4 O94574 YGDH_SCHPO 2.00E-09 GO:0051287; GO:0009436; GO:0047964; GO:0005739; GO:0005634; GO:0006111 NAD binding; glyoxylate catabolic process; glyoxylate reductase activity; mitochondrion; nucleus; regulation of gluconeogenesis IPR006139; IPR006140; IPR016040; Putative 2-hydroxyacid dehydrogenase C1773.17c (EC 1.-.-.-) SPBC1773.17c SPBP26C9.01c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38157_c1_g2_i7 P52643 LDHD_ECOLI 2.00E-08 GO:0008720; GO:0070404; GO:0019664; GO:0009408 D-lactate dehydrogenase activity; NADH binding; glucose catabolic process to mixed acids; response to heat IPR006139; IPR006140; IPR016040; D-lactate dehydrogenase (D-LDH) (EC 1.1.1.28) (Fermentative lactate dehydrogenase) ldhA hslI htpH b1380 JW1375 Escherichia coli (strain K12) TR38160_c6_g1_i1 A5D794 GAPD1_BOVIN 2.00E-91 GO:0032794; GO:0005096; GO:0005829; GO:0006897; GO:0005768; GO:0005085; GO:0016020; GO:0043547; GO:0051223; GO:0051056; GO:0007165 GTPase activating protein binding; GTPase activator activity; cytosol; endocytosis; endosome; guanyl-nucleotide exchange factor activity; membrane; positive regulation of GTPase activity; regulation of protein transport; regulation of small GTPase mediated signal transduction; signal transduction IPR001936; IPR008936; IPR003123; IPR013995; GTPase-activating protein and VPS9 domain-containing protein 1 GAPVD1 Bos taurus (Bovine) TR38160_c6_g2_i1 O18973 RABX5_BOVIN 3.00E-06 GO:0003677; GO:0005769; GO:0006897; GO:1900235; GO:0046580; GO:0050728; GO:1900165; GO:0002686; GO:0043305; GO:0001933; GO:0048261; GO:0015031; GO:0055037; GO:0060368; GO:0004842; GO:0031982; GO:0008270 Q9UJY5 DNA binding; early endosome; endocytosis; negative regulation of Kit signaling pathway; negative regulation of Ras protein signal transduction; negative regulation of inflammatory response; negative regulation of interleukin-6 secretion; negative regulation of leukocyte migration; negative regulation of mast cell degranulation; negative regulation of protein phosphorylation; negative regulation of receptor-mediated endocytosis; protein transport; recycling endosome; regulation of Fc receptor mediated stimulatory signaling pathway; ubiquitin-protein ligase activity; vesicle; zinc ion binding IPR003123; IPR013995; IPR002653; Rab5 GDP/GTP exchange factor (Rabex-5) RABGEF1 RABEX5 Bos taurus (Bovine) TR38160_c6_g2_i2 Q14C86 GAPD1_HUMAN 5.00E-30 GO:0032794; GO:0005096; GO:0005829; GO:0006897; GO:0005768; GO:0005085; GO:0016020; GO:0043547; GO:0051223; GO:0051056; GO:0007165 GTPase activating protein binding; GTPase activator activity; cytosol; endocytosis; endosome; guanyl-nucleotide exchange factor activity; membrane; positive regulation of GTPase activity; regulation of protein transport; regulation of small GTPase mediated signal transduction; signal transduction IPR001936; IPR008936; IPR003123; IPR013995; GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) GAPVD1 GAPEX5 KIAA1521 RAP6 Homo sapiens (Human) TR38161_c0_g3_i3 Q96HW7 INT4_HUMAN 0 GO:0032039; GO:0016180 integrator complex; snRNA processing IPR011989; IPR016024; Integrator complex subunit 4 (Int4) INTS4 MSTP093 Homo sapiens (Human) TR38161_c0_g3_i5 Q96HW7 INT4_HUMAN 0 GO:0032039; GO:0016180 integrator complex; snRNA processing IPR011989; IPR016024; Integrator complex subunit 4 (Int4) INTS4 MSTP093 Homo sapiens (Human) TR38163_c1_g1_i1 Q69BJ7 UCRI_SAISC 6.00E-86 GO:0051537; GO:0016021; GO:0046872; GO:0005743; GO:0070469; GO:0008121 "2 iron, 2 sulfur cluster binding; integral to membrane; metal ion binding; mitochondrial inner membrane; respiratory chain; ubiquinol-cytochrome-c reductase activity" IPR011070; IPR017941; IPR014349; IPR005805; IPR015248; IPR006317; IPR004192; "Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 1.10.2.2) (Complex III subunit 5) (Cytochrome b-c1 complex subunit 5) (Rieske iron-sulfur protein) (RISP) (Ubiquinol-cytochrome c reductase iron-sulfur subunit) [Cleaved into: Cytochrome b-c1 complex subunit 11 (Complex III subunit IX) (Ubiquinol-cytochrome c reductase 8 kDa protein)]" UQCRFS1 Saimiri sciureus (Common squirrel monkey) TR38163_c1_g1_i2 Q46GW1 UCRI_PROMT 1.00E-11 GO:0051537; GO:0045158; GO:0016021; GO:0046872; GO:0015979; GO:0009496; GO:0042651; GO:0008121 "2 iron, 2 sulfur cluster binding; electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity; integral to membrane; metal ion binding; photosynthesis; plastoquinol--plastocyanin reductase activity; thylakoid membrane; ubiquinol-cytochrome-c reductase activity" IPR014909; IPR023960; IPR017941; IPR014349; IPR005805; IPR006311; Cytochrome b6-f complex iron-sulfur subunit (EC 1.10.9.1) (Plastohydroquinone:plastocyanin oxidoreductase iron-sulfur protein) (ISP) (RISP) (Rieske iron-sulfur protein) petC PMN2A_1794 Prochlorococcus marinus (strain NATL2A) TR38163_c2_g5_i4 P28662 BRI3_MOUSE 9.00E-16 GO:0016021 integral to membrane IPR019317; Brain protein I3 Bri3 Mus musculus (Mouse) TR38164_c4_g1_i2 O43029 FAP1_SCHPO 6.00E-10 GO:0019477; GO:0050031; GO:0005829; GO:0005576; GO:0050660; GO:0005634; GO:0051699 L-lysine catabolic process; L-pipecolate oxidase activity; cytosol; extracellular region; flavin adenine dinucleotide binding; nucleus; proline oxidase activity IPR006076; L-pipecolate oxidase (EC 1.5.3.7) (L-pipecolic acid oxidase) fap1 SPBC354.15 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38165_c6_g4_i1 Q5SWH9 TMM69_HUMAN 3.00E-23 GO:0016021 integral to membrane IPR021836; Transmembrane protein 69 TMEM69 C1orf154 HSPC229 Homo sapiens (Human) TR38165_c6_g4_i2 Q0V9J0 TMM69_XENTR 2.00E-30 GO:0016021 integral to membrane IPR021836; Transmembrane protein 69 tmem69 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38166_c0_g1_i1 Q9SU67 RAC8_ARATH 2.00E-20 GO:0005525; GO:0003924; GO:0009738; GO:0005622; GO:0009788; GO:0005886; GO:0007264 GTP binding; GTPase activity; abscisic acid mediated signaling pathway; intracellular; negative regulation of abscisic acid mediated signaling pathway; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Rac-like GTP-binding protein ARAC8 (GTPase protein ROP10) ARAC8 ROP10 At3g48040 T17F15.90 Arabidopsis thaliana (Mouse-ear cress) TR38166_c0_g1_i3 Q5U316 RAB35_RAT 6.00E-104 GO:0019003; GO:0005525; GO:0031253; GO:1990090; GO:0045334; GO:0005905; GO:0000910; GO:0016197; GO:0010008; GO:0045171; GO:0042470; GO:0005739; GO:0031175; GO:0005546; GO:0036010; GO:0015031; GO:0007264 "GDP binding; GTP binding; cell projection membrane; cellular response to nerve growth factor stimulus; clathrin-coated endocytic vesicle; coated pit; cytokinesis; endosomal transport; endosome membrane; intercellular bridge; melanosome; mitochondrion; neuron projection development; phosphatidylinositol-4,5-bisphosphate binding; protein localization to endosome; protein transport; small GTPase mediated signal transduction" IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-35 Rab35 Rattus norvegicus (Rat) TR38167_c4_g1_i1 O76217 PE1_ANOGA 6.00E-06 GO:0008061; GO:0006030; GO:0005576 chitin binding; chitin metabolic process; extracellular region IPR002557; Peritrophin-1 (AgAper-1) (Peritrophic matrix protein 1) (Peritrophin A) Aper1 AGAP006795 Anopheles gambiae (African malaria mosquito) TR38167_c4_g1_i2 P29030 CHIT_BRUMA 7.00E-07 GO:0008061; GO:0006032; GO:0004568; GO:0005576; GO:0000272 chitin binding; chitin catabolic process; chitinase activity; extracellular region; polysaccharide catabolic process IPR002557; IPR011583; IPR001223; IPR001579; IPR013781; IPR017853; Endochitinase (EC 3.2.1.14) (MF1 antigen) Brugia malayi (Filarial nematode worm) TR38168_c1_g1_i1 O88738 BIRC6_MOUSE 0 GO:0005794; GO:0006915; GO:0051301; GO:0004869; GO:0005768; GO:0060711; GO:0016020; GO:0005815; GO:0030496; GO:0007067; GO:0043066; GO:0008284; GO:0032465; GO:0000922; GO:0060712; GO:0005802; GO:0004842 Golgi apparatus; apoptotic process; cell division; cysteine-type endopeptidase inhibitor activity; endosome; labyrinthine layer development; membrane; microtubule organizing center; midbody; mitosis; negative regulation of apoptotic process; positive regulation of cell proliferation; regulation of cytokinesis; spindle pole; spongiotrophoblast layer development; trans-Golgi network; ubiquitin-protein ligase activity IPR001370; IPR022103; IPR000608; IPR016135; IPR015943; IPR017986; Baculoviral IAP repeat-containing protein 6 (EC 6.3.2.-) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) Birc6 Kiaa1289 Mus musculus (Mouse) TR38168_c1_g4_i1 Q9NR09 BIRC6_HUMAN 4.00E-131 GO:0005794; GO:0006915; GO:0051301; GO:0004869; GO:0005768; GO:0060711; GO:0016020; GO:0005815; GO:0030496; GO:0007067; GO:0043066; GO:2001237; GO:0008284; GO:0006468; GO:0042127; GO:0032465; GO:0000922; GO:0060712; GO:0005802; GO:0004842 Q96A65; Q02241; Q02750; P53350 Golgi apparatus; apoptotic process; cell division; cysteine-type endopeptidase inhibitor activity; endosome; labyrinthine layer development; membrane; microtubule organizing center; midbody; mitosis; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; positive regulation of cell proliferation; protein phosphorylation; regulation of cell proliferation; regulation of cytokinesis; spindle pole; spongiotrophoblast layer development; trans-Golgi network; ubiquitin-protein ligase activity IPR001370; IPR022103; IPR000608; IPR016135; IPR015943; Baculoviral IAP repeat-containing protein 6 (EC 6.3.2.-) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) BIRC6 KIAA1289 Homo sapiens (Human) TR38171_c0_g3_i1 Q923S9 RAB30_MOUSE 8.00E-84 GO:0005525; GO:0031985; GO:0007030; GO:0005801; GO:0016020; GO:0015031; GO:0007264; GO:0005802 GTP binding; Golgi cisterna; Golgi organization; cis-Golgi network; membrane; protein transport; small GTPase mediated signal transduction; trans-Golgi network IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-30 Rab30 Rsb30 Mus musculus (Mouse) TR38172_c0_g1_i2 Q6B9X6 VWKA_DICDI 4.00E-13 GO:0005524; GO:0005516; GO:0031164; GO:0000331; GO:0005829; GO:0000281; GO:0031038; GO:0018209; GO:0018107; GO:0048471; GO:0004674; GO:0031156; GO:0031288 ATP binding; calmodulin binding; contractile vacuolar membrane; contractile vacuole; cytosol; mitotic cytokinesis; myosin II filament organization; peptidyl-serine modification; peptidyl-threonine phosphorylation; perinuclear region of cytoplasm; protein serine/threonine kinase activity; regulation of sorocarp development; sorocarp morphogenesis IPR011009; IPR004166; IPR002035; Alpha-protein kinase vwkA (EC 2.7.11.1) (von Willebrand factor A alpha-kinase) (vWF kinase) vwkA DDB_G0268144 Dictyostelium discoideum (Slime mold) TR38172_c0_g1_i5 Q5UQ35 YR811_MIMIV 5.00E-13 GO:0008270 zinc ion binding IPR002035; IPR002867; IPR001841; Putative ariadne-like RING finger protein R811 MIMI_R811 Acanthamoeba polyphaga mimivirus (APMV) TR38172_c0_g1_i6 Q6B9X6 VWKA_DICDI 3.00E-13 GO:0005524; GO:0005516; GO:0031164; GO:0000331; GO:0005829; GO:0000281; GO:0031038; GO:0018209; GO:0018107; GO:0048471; GO:0004674; GO:0031156; GO:0031288 ATP binding; calmodulin binding; contractile vacuolar membrane; contractile vacuole; cytosol; mitotic cytokinesis; myosin II filament organization; peptidyl-serine modification; peptidyl-threonine phosphorylation; perinuclear region of cytoplasm; protein serine/threonine kinase activity; regulation of sorocarp development; sorocarp morphogenesis IPR011009; IPR004166; IPR002035; Alpha-protein kinase vwkA (EC 2.7.11.1) (von Willebrand factor A alpha-kinase) (vWF kinase) vwkA DDB_G0268144 Dictyostelium discoideum (Slime mold) TR38173_c2_g1_i4 Q6R1L1 TAF7_CRIGR 6.00E-51 GO:0071339; GO:0006355; GO:0000296; GO:0005669; GO:0006367 "MLL1 complex; regulation of transcription, DNA-dependent; spermine transport; transcription factor TFIID complex; transcription initiation from RNA polymerase II promoter" IPR006751; Transcription initiation factor TFIID subunit 7 TAF7 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR38173_c2_g1_i5 Q6R1L1 TAF7_CRIGR 7.00E-51 GO:0071339; GO:0006355; GO:0000296; GO:0005669; GO:0006367 "MLL1 complex; regulation of transcription, DNA-dependent; spermine transport; transcription factor TFIID complex; transcription initiation from RNA polymerase II promoter" IPR006751; Transcription initiation factor TFIID subunit 7 TAF7 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR38174_c1_g2_i1 Q9JMJ4 PRP19_RAT 0 GO:0003677; GO:0006281; GO:0000974; GO:0071013; GO:0001833; GO:0008610; GO:0005811; GO:0000398; GO:0045665; GO:0016607; GO:0005634; GO:0048711; GO:0048026; GO:0000209; GO:0005819; GO:0000245; GO:0000151; GO:0034450 "DNA binding; DNA repair; Prp19 complex; catalytic step 2 spliceosome; inner cell mass cell proliferation; lipid biosynthetic process; lipid particle; mRNA splicing, via spliceosome; negative regulation of neuron differentiation; nuclear speck; nucleus; positive regulation of astrocyte differentiation; positive regulation of mRNA splicing, via spliceosome; protein polyubiquitination; spindle; spliceosomal complex assembly; ubiquitin ligase complex; ubiquitin-ubiquitin ligase activity" IPR020472; IPR013915; IPR000772; IPR003613; IPR015943; IPR001680; IPR019775; IPR017986; IPR013083; Pre-mRNA-processing factor 19 (Neuronal differentiation-related gene protein) (PRP19/PSO4 homolog) Prpf19 Prp19 Rattus norvegicus (Rat) TR38176_c4_g1_i1 Q54I18 SMEK_DICDI 2.00E-69 GO:0005938; GO:0043327; GO:0005634; GO:0030289; GO:0007165 Q9Y0B7 cell cortex; chemotaxis to cAMP; nucleus; protein phosphatase 4 complex; signal transduction IPR016024; IPR006887; Suppressor of Mek1 (SMEK) smkA DDB_G0289067 Dictyostelium discoideum (Slime mold) TR38176_c4_g1_i2 Q5SP90 PP4R3_DANRE 0 IPR016024; IPR006887; IPR011993; Serine/threonine-protein phosphatase 4 regulatory subunit 3 (SMEK homolog 1) smek1 si:dkey-65b13.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR38176_c4_g1_i4 Q5SP90 PP4R3_DANRE 0 IPR016024; IPR006887; IPR011993; Serine/threonine-protein phosphatase 4 regulatory subunit 3 (SMEK homolog 1) smek1 si:dkey-65b13.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR38176_c4_g2_i1 Q54I18 SMEK_DICDI 2.00E-11 GO:0005938; GO:0043327; GO:0005634; GO:0030289; GO:0007165 Q9Y0B7 cell cortex; chemotaxis to cAMP; nucleus; protein phosphatase 4 complex; signal transduction IPR016024; IPR006887; Suppressor of Mek1 (SMEK) smkA DDB_G0289067 Dictyostelium discoideum (Slime mold) TR38176_c4_g3_i1 Q9VFS5 PP4R3_DROME 9.00E-56 GO:0006281; GO:0055059; GO:0008105; GO:0005737; GO:0016020; GO:0005634; GO:0006909; GO:0030289 DNA repair; asymmetric neuroblast division; asymmetric protein localization; cytoplasm; membrane; nucleus; phagocytosis; protein phosphatase 4 complex IPR016024; IPR006887; IPR011993; Serine/threonine-protein phosphatase 4 regulatory subunit 3 (PP4R3) (Protein falafel) flfl CG9351 Drosophila melanogaster (Fruit fly) TR38176_c4_g3_i2 Q6CQ91 PP4R3_KLULA 9.00E-07 GO:0005634 nucleus IPR016024; IPR006887; Serine/threonine-protein phosphatase 4 regulatory subunit 3 (PP4R3) PSY2 KLLA0D18887g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR38178_c1_g1_i1 A6QP70 SGCB_BOVIN 2.00E-35 GO:0035051; GO:0005737; GO:0005856; GO:0016021; GO:0007517; GO:0016012; GO:0042383 cardiocyte differentiation; cytoplasm; cytoskeleton; integral to membrane; muscle organ development; sarcoglycan complex; sarcolemma IPR006875; IPR027659; Beta-sarcoglycan (Beta-SG) SGCB Bos taurus (Bovine) TR38178_c1_g1_i4 Q28635 SGCB_RABIT 7.00E-35 GO:0035051; GO:0005737; GO:0005856; GO:0016021; GO:0007517; GO:0016012; GO:0042383 cardiocyte differentiation; cytoplasm; cytoskeleton; integral to membrane; muscle organ development; sarcoglycan complex; sarcolemma IPR006875; IPR027659; Beta-sarcoglycan (Beta-SG) SGCB Oryctolagus cuniculus (Rabbit) TR38178_c1_g1_i8 A6QP70 SGCB_BOVIN 3.00E-35 GO:0035051; GO:0005737; GO:0005856; GO:0016021; GO:0007517; GO:0016012; GO:0042383 cardiocyte differentiation; cytoplasm; cytoskeleton; integral to membrane; muscle organ development; sarcoglycan complex; sarcolemma IPR006875; IPR027659; Beta-sarcoglycan (Beta-SG) SGCB Bos taurus (Bovine) TR38179_c0_g2_i1 Q6Q0C0 TRAF7_HUMAN 0 GO:0000185; GO:0016023; GO:0097194; GO:0043231; GO:0005886; GO:0043410; GO:0006355; GO:0006351; GO:0000151; GO:0004842; GO:0008270 Q99759; Q9ERK0 "activation of MAPKKK activity; cytoplasmic membrane-bounded vesicle; execution phase of apoptosis; intracellular membrane-bounded organelle; plasma membrane; positive regulation of MAPK cascade; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin ligase complex; ubiquitin-protein ligase activity; zinc ion binding" IPR020472; IPR013323; IPR008974; IPR015943; IPR001680; IPR019775; IPR017986; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRAF7 (EC 6.3.2.-) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (TNF receptor-associated factor 7) TRAF7 RFWD1 RNF119 Homo sapiens (Human) TR38179_c0_g2_i10 Q8YRI1 YY46_NOSS1 1.00E-23 GO:0006355 "regulation of transcription, DNA-dependent" IPR001646; IPR020472; IPR007111; IPR027417; IPR011047; IPR027728; IPR015943; IPR001680; IPR019775; IPR017986; Uncharacterized WD repeat-containing protein alr3466 alr3466 Nostoc sp. (strain PCC 7120 / UTEX 2576) TR38179_c0_g2_i2 Q00808 HETE1_PODAS 1.00E-33 GO:0005525 GTP binding IPR020472; IPR010730; IPR007111; IPR027417; IPR015943; IPR001680; IPR019775; IPR017986; Vegetative incompatibility protein HET-E-1 HET-E1 Podospora anserina (Pleurage anserina) TR38179_c0_g2_i3 Q969H0 FBXW7_HUMAN 4.00E-27 GO:0005794; GO:0007219; GO:0019005; GO:0031146; GO:0034644; GO:0005783; GO:0055088; GO:0030324; GO:0019048; GO:0032876; GO:0045746; GO:2000639; GO:2000346; GO:0010868; GO:0005730; GO:0005654; GO:0070374; GO:0045741; GO:2000060; GO:0043234; GO:0050821; GO:0016567; GO:0010883; GO:0032880; GO:0006974; GO:0003700; GO:0007062; GO:0001944; GO:0001570 Q16204; P24941; P01106; P63208; Q9UBI4 Golgi apparatus; Notch signaling pathway; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cellular response to UV; endoplasmic reticulum; lipid homeostasis; lung development; modulation by virus of host morphology or physiology; negative regulation of DNA endoreduplication; negative regulation of Notch signaling pathway; negative regulation of SREBP signaling pathway; negative regulation of hepatocyte proliferation; negative regulation of triglyceride biosynthetic process; nucleolus; nucleoplasm; positive regulation of ERK1 and ERK2 cascade; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein complex; protein stabilization; protein ubiquitination; regulation of lipid storage; regulation of protein localization; response to DNA damage stimulus; sequence-specific DNA binding transcription factor activity; sister chromatid cohesion; vasculature development; vasculogenesis IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4) FBXW7 FBW7 FBX30 SEL10 Homo sapiens (Human) TR38179_c0_g2_i4 P90648 MHCKB_DICDI 3.00E-37 GO:0005524; GO:0005826; GO:0000281; GO:0031037; GO:0016905; GO:0018107; GO:0046777 ATP binding; actomyosin contractile ring; mitotic cytokinesis; myosin II filament disassembly; myosin heavy chain kinase activity; peptidyl-threonine phosphorylation; protein autophosphorylation IPR020472; IPR011009; IPR004166; IPR015943; IPR001680; IPR019775; IPR017986; Myosin heavy chain kinase B (MHCK-B) (EC 2.7.11.7) mhkB mhckB DDB_G0289115 Dictyostelium discoideum (Slime mold) TR38179_c0_g2_i5 Q6Q0C0 TRAF7_HUMAN 0 GO:0000185; GO:0016023; GO:0097194; GO:0043231; GO:0005886; GO:0043410; GO:0006355; GO:0006351; GO:0000151; GO:0004842; GO:0008270 Q99759; Q9ERK0 "activation of MAPKKK activity; cytoplasmic membrane-bounded vesicle; execution phase of apoptosis; intracellular membrane-bounded organelle; plasma membrane; positive regulation of MAPK cascade; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin ligase complex; ubiquitin-protein ligase activity; zinc ion binding" IPR020472; IPR013323; IPR008974; IPR015943; IPR001680; IPR019775; IPR017986; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRAF7 (EC 6.3.2.-) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (TNF receptor-associated factor 7) TRAF7 RFWD1 RNF119 Homo sapiens (Human) TR38179_c0_g2_i6 Q6ZMY6 WDR88_HUMAN 7.00E-07 IPR020472; IPR018391; IPR002372; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 88 (PQQ repeat and WD repeat-containing protein) WDR88 PQWD Homo sapiens (Human) TR38179_c0_g2_i8 Q969H0 FBXW7_HUMAN 4.00E-27 GO:0005794; GO:0007219; GO:0019005; GO:0031146; GO:0034644; GO:0005783; GO:0055088; GO:0030324; GO:0019048; GO:0032876; GO:0045746; GO:2000639; GO:2000346; GO:0010868; GO:0005730; GO:0005654; GO:0070374; GO:0045741; GO:2000060; GO:0043234; GO:0050821; GO:0016567; GO:0010883; GO:0032880; GO:0006974; GO:0003700; GO:0007062; GO:0001944; GO:0001570 Q16204; P24941; P01106; P63208; Q9UBI4 Golgi apparatus; Notch signaling pathway; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cellular response to UV; endoplasmic reticulum; lipid homeostasis; lung development; modulation by virus of host morphology or physiology; negative regulation of DNA endoreduplication; negative regulation of Notch signaling pathway; negative regulation of SREBP signaling pathway; negative regulation of hepatocyte proliferation; negative regulation of triglyceride biosynthetic process; nucleolus; nucleoplasm; positive regulation of ERK1 and ERK2 cascade; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein complex; protein stabilization; protein ubiquitination; regulation of lipid storage; regulation of protein localization; response to DNA damage stimulus; sequence-specific DNA binding transcription factor activity; sister chromatid cohesion; vasculature development; vasculogenesis IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4) FBXW7 FBW7 FBX30 SEL10 Homo sapiens (Human) TR38179_c0_g2_i9 Q6Q0C0 TRAF7_HUMAN 0 GO:0000185; GO:0016023; GO:0097194; GO:0043231; GO:0005886; GO:0043410; GO:0006355; GO:0006351; GO:0000151; GO:0004842; GO:0008270 Q99759; Q9ERK0 "activation of MAPKKK activity; cytoplasmic membrane-bounded vesicle; execution phase of apoptosis; intracellular membrane-bounded organelle; plasma membrane; positive regulation of MAPK cascade; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin ligase complex; ubiquitin-protein ligase activity; zinc ion binding" IPR020472; IPR013323; IPR008974; IPR015943; IPR001680; IPR019775; IPR017986; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRAF7 (EC 6.3.2.-) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (TNF receptor-associated factor 7) TRAF7 RFWD1 RNF119 Homo sapiens (Human) TR3818_c0_g1_i1 Q02386 ZNF45_HUMAN 4.00E-12 GO:0003677; GO:0046872; GO:0007275; GO:0005654; GO:0003700; GO:0006367 DNA binding; metal ion binding; multicellular organismal development; nucleoplasm; sequence-specific DNA binding transcription factor activity; transcription initiation from RNA polymerase II promoter IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 45 (BRC1744) (Zinc finger protein 13) (Zinc finger protein KOX5) ZNF45 KOX5 ZNF13 Homo sapiens (Human) TR38184_c1_g2_i1 P86409 RGPA1_PIG 9.00E-38 GO:0017123; GO:0032859; GO:0005737; GO:0005634 Ral GTPase activator activity; activation of Ral GTPase activity; cytoplasm; nucleus IPR027107; Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) (Fragment) RALGAPA1 GARNL1 TULIP1 Sus scrofa (Pig) TR38184_c3_g1_i1 Q6GYP7 RGPA1_MOUSE 5.00E-59 GO:0017123; GO:0032859; GO:0005829; GO:0005634; GO:0006355 "Ral GTPase activator activity; activation of Ral GTPase activity; cytosol; nucleus; regulation of transcription, DNA-dependent" IPR016024; IPR000331; IPR027107; Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating RapGAP domain-like 1) (Tuberin-like protein 1) (p240) Ralgapa1 Garnl1 Kiaa0884 Tulip1 Mus musculus (Mouse) TR38184_c3_g1_i2 Q6GYQ0 RGPA1_HUMAN 3.00E-60 GO:0017123; GO:0032859; GO:0005829; GO:0005739; GO:0005634; GO:0006355 "Ral GTPase activator activity; activation of Ral GTPase activity; cytosol; mitochondrion; nucleus; regulation of transcription, DNA-dependent" IPR016024; IPR000331; IPR027107; Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) RALGAPA1 GARNL1 KIAA0884 TULIP1 Homo sapiens (Human) TR38184_c6_g2_i1 Q6GYQ0 RGPA1_HUMAN 2.00E-162 GO:0017123; GO:0032859; GO:0005829; GO:0005739; GO:0005634; GO:0006355 "Ral GTPase activator activity; activation of Ral GTPase activity; cytosol; mitochondrion; nucleus; regulation of transcription, DNA-dependent" IPR016024; IPR000331; IPR027107; Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) RALGAPA1 GARNL1 KIAA0884 TULIP1 Homo sapiens (Human) TR38185_c0_g1_i2 Q2KJJ5 TBL3_BOVIN 0 GO:0005730; GO:0006364; GO:0032040 nucleolus; rRNA processing; small-subunit processome IPR020472; IPR013934; IPR015943; IPR001680; IPR019775; IPR017986; Transducin beta-like protein 3 TBL3 Bos taurus (Bovine) TR38186_c0_g2_i1 Q6DGA6 ALLC_DANRE 7.00E-154 GO:0004037; GO:0000256; GO:0006144 allantoicase activity; allantoin catabolic process; purine nucleobase metabolic process IPR005164; IPR015908; IPR008979; Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1. Allantoicase (EC 3.5.3.4) (Allantoate amidinohydrolase) allc si:ch211-284k10.3 zgc:91799 Danio rerio (Zebrafish) (Brachydanio rerio) TR38186_c0_g2_i4 Q6DGA6 ALLC_DANRE 5.00E-154 GO:0004037; GO:0000256; GO:0006144 allantoicase activity; allantoin catabolic process; purine nucleobase metabolic process IPR005164; IPR015908; IPR008979; Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1. Allantoicase (EC 3.5.3.4) (Allantoate amidinohydrolase) allc si:ch211-284k10.3 zgc:91799 Danio rerio (Zebrafish) (Brachydanio rerio) TR38187_c0_g1_i1 Q6RY07 CHIA_RAT 5.00E-130 GO:0006915; GO:0008061; GO:0006032; GO:0004568; GO:0005737; GO:0005615; GO:0000272; GO:0090197; GO:0002532 apoptotic process; chitin binding; chitin catabolic process; chitinase activity; cytoplasm; extracellular space; polysaccharide catabolic process; positive regulation of chemokine secretion; production of molecular mediator involved in inflammatory response IPR002557; IPR011583; IPR001223; IPR001579; IPR013781; IPR017853; Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) Chia Rattus norvegicus (Rat) TR38187_c0_g1_i3 Q12889 OVGP1_HUMAN 2.00E-89 GO:0007339; GO:0005975; GO:0006032; GO:0004568; GO:0005829; GO:0007565; GO:0032504; GO:0030133 binding of sperm to zona pellucida; carbohydrate metabolic process; chitin catabolic process; chitinase activity; cytosol; female pregnancy; multicellular organism reproduction; transport vesicle IPR011583; IPR001223; IPR013781; IPR017853; Oviduct-specific glycoprotein (Estrogen-dependent oviduct protein) (Mucin-9) (Oviductal glycoprotein) (Oviductin) OVGP1 MUC9 OGP Homo sapiens (Human) TR38187_c0_g1_i4 P96156 CHID_VIBFU 3.00E-14 GO:0030246; GO:0006032; GO:0004568; GO:0005576; GO:0042597; GO:0000272 carbohydrate binding; chitin catabolic process; chitinase activity; extracellular region; periplasmic space; polysaccharide catabolic process IPR003610; IPR009470; IPR011583; IPR001223; IPR013781; IPR017853; Glycan degradation; chitin degradation. Chitodextrinase (EC 3.2.1.14) endo I Vibrio furnissii TR38187_c0_g1_i5 Q6RY07 CHIA_RAT 4.00E-126 GO:0006915; GO:0008061; GO:0006032; GO:0004568; GO:0005737; GO:0005615; GO:0000272; GO:0090197; GO:0002532 apoptotic process; chitin binding; chitin catabolic process; chitinase activity; cytoplasm; extracellular space; polysaccharide catabolic process; positive regulation of chemokine secretion; production of molecular mediator involved in inflammatory response IPR002557; IPR011583; IPR001223; IPR001579; IPR013781; IPR017853; Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) Chia Rattus norvegicus (Rat) TR38187_c0_g1_i6 Q9BZP6 CHIA_HUMAN 5.00E-120 GO:0006915; GO:0030246; GO:0006037; GO:0008061; GO:0006032; GO:0004568; GO:0005737; GO:0007586; GO:0005615; GO:0006955; GO:0003796; GO:0000272; GO:0090197; GO:0002532; GO:0001101; GO:0009620 apoptotic process; carbohydrate binding; cell wall chitin metabolic process; chitin binding; chitin catabolic process; chitinase activity; cytoplasm; digestion; extracellular space; immune response; lysozyme activity; polysaccharide catabolic process; positive regulation of chemokine secretion; production of molecular mediator involved in inflammatory response; response to acid; response to fungus IPR002557; IPR011583; IPR001223; IPR001579; IPR013781; IPR017853; Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Lung-specific protein TSA1902) CHIA Homo sapiens (Human) TR38189_c0_g1_i2 Q2KJ69 CL029_BOVIN 3.00E-93 Uncharacterized protein C12orf29 homolog Bos taurus (Bovine) TR38189_c0_g1_i3 Q6AXM9 CL029_RAT 1.00E-93 Uncharacterized protein C12orf29 homolog Rattus norvegicus (Rat) TR38191_c0_g1_i2 P50591 TNF10_HUMAN 2.00E-16 GO:0006919; GO:0097190; GO:0007267; GO:0005576; GO:0005615; GO:0006955; GO:0005887; GO:0046872; GO:0043123; GO:0043065; GO:2001238; GO:0090200; GO:0005102; GO:2001239 Q13618; O00220; O14763 activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic signaling pathway; cell-cell signaling; extracellular region; extracellular space; immune response; integral to plasma membrane; metal ion binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptotic process; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of release of cytochrome c from mitochondria; receptor binding; regulation of extrinsic apoptotic signaling pathway in absence of ligand IPR021184; IPR006052; IPR017355; IPR008983; Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253) TNFSF10 APO2L TRAIL Homo sapiens (Human) TR38191_c0_g1_i3 P41047 TNFL6_MOUSE 7.00E-16 GO:0070231; GO:0006919; GO:0060555; GO:0060554; GO:0005901; GO:0030644; GO:0033554; GO:0060205; GO:0048388; GO:0009897; GO:0005615; GO:0070062; GO:0008625; GO:0006955; GO:0006925; GO:0016021; GO:0043202; GO:0070265; GO:0016525; GO:0000122; GO:0005634; GO:0048471; GO:0043123; GO:0043065; GO:0008284; GO:2000353; GO:0045742; GO:0043525; GO:0070848; GO:0032496; GO:0046666; GO:0006351 "T cell apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of necroptosis by extracellular signals; activation of necroptosis of activated-T cells; caveola; cellular chloride ion homeostasis; cellular response to stress; cytoplasmic membrane-bounded vesicle lumen; endosomal lumen acidification; external side of plasma membrane; extracellular space; extracellular vesicular exosome; extrinsic apoptotic signaling pathway via death domain receptors; immune response; inflammatory cell apoptotic process; integral to membrane; lysosomal lumen; necrotic cell death; negative regulation of angiogenesis; negative regulation of transcription from RNA polymerase II promoter; nucleus; perinuclear region of cytoplasm; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptotic process; positive regulation of cell proliferation; positive regulation of endothelial cell apoptotic process; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of neuron apoptotic process; response to growth factor stimulus; response to lipopolysaccharide; retinal cell programmed cell death; transcription, DNA-dependent" IPR028326; IPR006053; IPR021184; IPR006052; IPR008983; "Tumor necrosis factor ligand superfamily member 6 (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]" Faslg Apt1lg1 Cd95l Fasl gld Tnfsf6 Mus musculus (Mouse) TR38191_c0_g1_i6 P50591 TNF10_HUMAN 1.00E-16 GO:0006919; GO:0097190; GO:0007267; GO:0005576; GO:0005615; GO:0006955; GO:0005887; GO:0046872; GO:0043123; GO:0043065; GO:2001238; GO:0090200; GO:0005102; GO:2001239 Q13618; O00220; O14763 activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic signaling pathway; cell-cell signaling; extracellular region; extracellular space; immune response; integral to plasma membrane; metal ion binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptotic process; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of release of cytochrome c from mitochondria; receptor binding; regulation of extrinsic apoptotic signaling pathway in absence of ligand IPR021184; IPR006052; IPR017355; IPR008983; Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253) TNFSF10 APO2L TRAIL Homo sapiens (Human) TR38191_c0_g1_i7 P36940 TNFL6_RAT 7.00E-15 GO:0070231; GO:0006919; GO:0060555; GO:0060554; GO:0005901; GO:0030644; GO:0016023; GO:0060205; GO:0005123; GO:0048388; GO:0009897; GO:0005615; GO:0070062; GO:0008625; GO:0006955; GO:0006925; GO:0016021; GO:0043202; GO:0070265; GO:0016525; GO:0000122; GO:0005634; GO:0048471; GO:0043123; GO:0008284; GO:2000353; GO:0045742; GO:0043525; GO:0070848; GO:0032496; GO:0046666; GO:0006351; GO:0005164 "T cell apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of necroptosis by extracellular signals; activation of necroptosis of activated-T cells; caveola; cellular chloride ion homeostasis; cytoplasmic membrane-bounded vesicle; cytoplasmic membrane-bounded vesicle lumen; death receptor binding; endosomal lumen acidification; external side of plasma membrane; extracellular space; extracellular vesicular exosome; extrinsic apoptotic signaling pathway via death domain receptors; immune response; inflammatory cell apoptotic process; integral to membrane; lysosomal lumen; necrotic cell death; negative regulation of angiogenesis; negative regulation of transcription from RNA polymerase II promoter; nucleus; perinuclear region of cytoplasm; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of cell proliferation; positive regulation of endothelial cell apoptotic process; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of neuron apoptotic process; response to growth factor stimulus; response to lipopolysaccharide; retinal cell programmed cell death; transcription, DNA-dependent; tumor necrosis factor receptor binding" IPR028326; IPR021184; IPR006052; IPR008983; "Tumor necrosis factor ligand superfamily member 6 (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]" Faslg Apt1Lg1 Cd95l Fasl Tnfsf6 Rattus norvegicus (Rat) TR38191_c0_g2_i3 P51742 TNFA_CANFA 1.00E-08 GO:0007254; GO:0000187; GO:0000185; GO:0006919; GO:0060555; GO:0071230; GO:0071316; GO:0002439; GO:0050830; GO:0048566; GO:0060664; GO:0009897; GO:0030198; GO:0005615; GO:0008625; GO:0006006; GO:0006959; GO:0005887; GO:0050901; GO:0031663; GO:0045121; GO:0070265; GO:0010693; GO:0061048; GO:0002740; GO:2001240; GO:0046325; GO:0044130; GO:0032715; GO:0050995; GO:0045668; GO:0043242; GO:0000122; GO:0045071; GO:0009887; GO:0030316; GO:0001891; GO:0043123; GO:0046330; GO:0043507; GO:0042346; GO:0051092; GO:0051533; GO:0043065; GO:0060559; GO:2000343; GO:0045080; GO:0002876; GO:0050715; GO:0031622; GO:0051798; GO:0034116; GO:0002925; GO:0032729; GO:0032755; GO:0045416; GO:0051044; GO:0045429; GO:0045672; GO:0033138; GO:0071803; GO:0043243; GO:0051897; GO:2000010; GO:0048661; GO:0045944; GO:0045994; GO:0060557; GO:0000060; GO:0043491; GO:0032800; GO:0055037; GO:0060693; GO:0051023; GO:0050796; GO:0051384; GO:0009615; GO:0030730; GO:0044212; GO:0006927; GO:0033209 "JNK cascade; activation of MAPK activity; activation of MAPKKK activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of necroptosis by extracellular signals; cellular response to amino acid stimulus; cellular response to nicotine; chronic inflammatory response to antigenic stimulus; defense response to Gram-positive bacterium; embryonic digestive tract development; epithelial cell proliferation involved in salivary gland morphogenesis; external side of plasma membrane; extracellular matrix organization; extracellular space; extrinsic apoptotic signaling pathway via death domain receptors; glucose metabolic process; humoral immune response; integral to plasma membrane; leukocyte tethering or rolling; lipopolysaccharide-mediated signaling pathway; membrane raft; necrotic cell death; negative regulation of alkaline phosphatase activity; negative regulation of branching involved in lung morphogenesis; negative regulation of cytokine secretion involved in immune response; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of glucose import; negative regulation of growth of symbiont in host; negative regulation of interleukin-6 production; negative regulation of lipid catabolic process; negative regulation of osteoblast differentiation; negative regulation of protein complex disassembly; negative regulation of transcription from RNA polymerase II promoter; negative regulation of viral genome replication; organ morphogenesis; osteoclast differentiation; phagocytic cup; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of NF-kappaB import into nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of NFAT protein import into nucleus; positive regulation of apoptotic process; positive regulation of calcidiol 1-monooxygenase activity; positive regulation of chemokine (C-X-C motif) ligand 2 production; positive regulation of chemokine biosynthetic process; positive regulation of chronic inflammatory response to antigenic stimulus; positive regulation of cytokine secretion; positive regulation of fever generation; positive regulation of hair follicle development; positive regulation of heterotypic cell-cell adhesion; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of interferon-gamma production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 biosynthetic process; positive regulation of membrane protein ectodomain proteolysis; positive regulation of nitric oxide biosynthetic process; positive regulation of osteoclast differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of podosome assembly; positive regulation of protein complex disassembly; positive regulation of protein kinase B signaling cascade; positive regulation of protein localization to cell surface; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of translational initiation by iron; positive regulation of vitamin D biosynthetic process; protein import into nucleus, translocation; protein kinase B signaling cascade; receptor biosynthetic process; recycling endosome; regulation of branching involved in salivary gland morphogenesis; regulation of immunoglobulin secretion; regulation of insulin secretion; response to glucocorticoid stimulus; response to virus; sequestering of triglyceride; transcription regulatory region DNA binding; transformed cell apoptotic process; tumor necrosis factor-mediated signaling pathway" IPR006053; IPR002959; IPR021184; IPR006052; IPR008064; IPR008983; "Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]" TNF TNFA TNFSF2 Canis familiaris (Dog) (Canis lupus familiaris) TR38192_c2_g1_i1 P97814 PPIP1_MOUSE 5.00E-44 GO:0003779; GO:0005826; GO:0007155; GO:0032154; GO:0030027; GO:0048471; GO:0019903; GO:0001725 P00520; P35831; Q61152 actin binding; actomyosin contractile ring; cell adhesion; cleavage furrow; lamellipodium; perinuclear region of cytoplasm; protein phosphatase binding; stress fiber IPR001060; IPR001452; IPR013315; Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) Pstpip1 Mus musculus (Mouse) TR38192_c2_g1_i2 P97814 PPIP1_MOUSE 2.00E-46 GO:0003779; GO:0005826; GO:0007155; GO:0032154; GO:0030027; GO:0048471; GO:0019903; GO:0001725 P00520; P35831; Q61152 actin binding; actomyosin contractile ring; cell adhesion; cleavage furrow; lamellipodium; perinuclear region of cytoplasm; protein phosphatase binding; stress fiber IPR001060; IPR001452; IPR013315; Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) Pstpip1 Mus musculus (Mouse) TR38193_c0_g2_i1 P32780 TF2H1_HUMAN 1.00E-118 GO:0006370; GO:0000439; GO:0005675; GO:0000718; GO:0045944; GO:0050434; GO:0006468; GO:0000079; GO:0006363; GO:0006362; GO:0006368; GO:0006361; GO:0006367; GO:0006283; GO:0016032 P29083; P04637; Q01831 "7-methylguanosine mRNA capping; core TFIIH complex; holo TFIIH complex; nucleotide-excision repair, DNA damage removal; positive regulation of transcription from RNA polymerase II promoter; positive regulation of viral transcription; protein phosphorylation; regulation of cyclin-dependent protein serine/threonine kinase activity; termination of RNA polymerase I transcription; transcription elongation from RNA polymerase I promoter; transcription elongation from RNA polymerase II promoter; transcription initiation from RNA polymerase I promoter; transcription initiation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair; viral process" IPR005607; IPR011993; IPR027079; IPR013876; General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit) GTF2H1 BTF2 Homo sapiens (Human) TR38193_c0_g2_i2 Q3ECP0 TFB1A_ARATH 7.00E-23 GO:0000439; GO:0006289; GO:0006355; GO:0006351 "core TFIIH complex; nucleotide-excision repair; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR005607; IPR011993; IPR027079; Probable RNA polymerase II transcription factor B subunit 1-1 (General transcription and DNA repair factor IIH subunit TFB1-1) (AtTFB1-1) (TFIIH subunit TFB1-1) TFB1-1 At1g55750 F20N2.15 Arabidopsis thaliana (Mouse-ear cress) TR38194_c2_g2_i2 Q6UR05 MRP1_CANFA 7.00E-118 GO:0005524; GO:0006200; GO:0042626; GO:0016021; GO:0005886 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; plasma membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP1 Canis familiaris (Dog) (Canis lupus familiaris) TR38194_c2_g2_i3 P33527 MRP1_HUMAN 2.00E-68 GO:0005524; GO:0042626; GO:0005794; GO:0019369; GO:0009235; GO:0005887; GO:0006691; GO:0005634; GO:0042493 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; Golgi apparatus; arachidonic acid metabolic process; cobalamin metabolic process; integral to plasma membrane; leukotriene metabolic process; nucleus; response to drug" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP MRP1 Homo sapiens (Human) TR38195_c0_g1_i3 Q62559 IFT52_MOUSE 0 GO:0036064; GO:0044292; GO:0009953; GO:0042733; GO:0001947; GO:0001841; GO:0032391; GO:0045862; GO:0007224 Q8N4P2 cilium basal body; dendrite terminus; dorsal/ventral pattern formation; embryonic digit morphogenesis; heart looping; neural tube formation; photoreceptor connecting cilium; positive regulation of proteolysis; smoothened signaling pathway IPR019196; Intraflagellar transport protein 52 homolog (Protein NGD5) Ift52 Ngd5 Mus musculus (Mouse) TR38195_c0_g1_i4 Q62559 IFT52_MOUSE 0 GO:0036064; GO:0044292; GO:0009953; GO:0042733; GO:0001947; GO:0001841; GO:0032391; GO:0045862; GO:0007224 Q8N4P2 cilium basal body; dendrite terminus; dorsal/ventral pattern formation; embryonic digit morphogenesis; heart looping; neural tube formation; photoreceptor connecting cilium; positive regulation of proteolysis; smoothened signaling pathway IPR019196; Intraflagellar transport protein 52 homolog (Protein NGD5) Ift52 Ngd5 Mus musculus (Mouse) TR38198_c1_g1_i1 Q925P2 CEAM2_MOUSE 1.00E-11 GO:0009897; GO:0016021; GO:0019048; GO:0070348; GO:2000252; GO:2000505 external side of plasma membrane; integral to membrane; modulation by virus of host morphology or physiology; negative regulation of brown fat cell proliferation; negative regulation of feeding behavior; regulation of energy homeostasis IPR007110; IPR013783; IPR003599; IPR003598; IPR013106; Carcinoembryonic antigen-related cell adhesion molecule 2 (CEA-related cell adhesion molecule 2) (Biliary glycoprotein 2) (BGP-2) Ceacam2 Bgp2 Mus musculus (Mouse) TR38198_c1_g1_i2 O35136 NCAM2_MOUSE 8.00E-13 GO:0031225; GO:0030424; GO:0007155; GO:0016021; GO:0005886 anchored to membrane; axon; cell adhesion; integral to membrane; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR009138; Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2) (Neural cell adhesion molecule RB-8) (R4B12) Ncam2 Ocam Rncam Mus musculus (Mouse) TR38198_c1_g1_i5 Q9UQ74 PSG8_HUMAN 3.00E-08 GO:0005576 extracellular region IPR007110; IPR013783; IPR003599; IPR003598; IPR013106; Pregnancy-specific beta-1-glycoprotein 8 (PS-beta-G-8) (PSBG-8) (Pregnancy-specific glycoprotein 8) PSG8 Homo sapiens (Human) TR38200_c2_g1_i1 Q641F3 COLA1_XENLA 6.00E-30 GO:0005581; GO:0005737 collagen; cytoplasm IPR008160; IPR008985; IPR013320; IPR001791; IPR002035; Collagen alpha-1(XXI) chain col21a1 Xenopus laevis (African clawed frog) TR38200_c2_g1_i2 O08746 MATN2_MOUSE 3.00E-28 GO:0007411; GO:0005604; GO:0005509; GO:0031104; GO:0008347; GO:0001764; GO:0048678 axon guidance; basement membrane; calcium ion binding; dendrite regeneration; glial cell migration; neuron migration; response to axon injury IPR000742; IPR001881; IPR013032; IPR000152; IPR009030; IPR019466; IPR002035; Matrilin-2 Matn2 Mus musculus (Mouse) TR38201_c0_g1_i1 O43242 PSMD3_HUMAN 0 GO:0006977; GO:0000082; GO:0031145; GO:0002479; GO:0006915; GO:0005829; GO:0030234; GO:0010467; GO:0016071; GO:0043066; GO:0051436; GO:0005654; GO:0051437; GO:0022624; GO:0000209; GO:0006521; GO:0042176; GO:0044281; GO:0016032 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G1/S transition of mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic process; cytosol; enzyme regulator activity; gene expression; mRNA metabolic process; negative regulation of apoptotic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; proteasome accessory complex; protein polyubiquitination; regulation of cellular amino acid metabolic process; regulation of protein catabolic process; small molecule metabolic process; viral process" IPR013586; IPR013143; IPR000717; IPR011990; IPR011991; 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58) PSMD3 Homo sapiens (Human) TR38203_c1_g1_i1 O94966 UBP19_HUMAN 2.00E-138 GO:0030433; GO:0005829; GO:0005789; GO:0016021; GO:0046872; GO:0048642; GO:0090068; GO:0016579; GO:1900037; GO:0031647; GO:0034976; GO:0014732; GO:0004221; GO:0004843 ER-associated protein catabolic process; cytosol; endoplasmic reticulum membrane; integral to membrane; metal ion binding; negative regulation of skeletal muscle tissue development; positive regulation of cell cycle process; protein deubiquitination; regulation of cellular response to hypoxia; regulation of protein stability; response to endoplasmic reticulum stress; skeletal muscle atrophy; ubiquitin thiolesterase activity; ubiquitin-specific protease activity IPR007052; IPR008978; IPR018200; IPR001394; IPR002893; Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9) USP19 KIAA0891 ZMYND9 Homo sapiens (Human) TR38205_c2_g2_i1 Q9BYG0 B3GN5_HUMAN 3.00E-25 GO:0000139; GO:0016266; GO:0008457; GO:0007417; GO:0008378; GO:0009247; GO:0016021; GO:0047256; GO:0008917; GO:0043687 "Golgi membrane; O-glycan processing; beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity; central nervous system development; galactosyltransferase activity; glycolipid biosynthetic process; integral to membrane; lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity; lipopolysaccharide N-acetylglucosaminyltransferase activity; post-translational protein modification" IPR002659; Protein modification; protein glycosylation. "Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (EC 2.4.1.206) (Lactotriaosylceramide synthase) (Lc(3)Cer synthase) (Lc3 synthase) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5) (BGnT-5) (Beta-1,3-Gn-T5) (Beta-1,3-N-acetylglucosaminyltransferase 5) (Beta3Gn-T5)" B3GNT5 Homo sapiens (Human) TR38205_c2_g2_i3 Q6AY39 B3GL1_RAT 9.00E-19 GO:0000139; GO:0008499; GO:0047273; GO:0016021; GO:0009312; GO:0006486 "Golgi membrane; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity; integral to membrane; oligosaccharide biosynthetic process; protein glycosylation" IPR002659; Protein modification; protein glycosylation. "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (Beta-1,3-GalNAc-T1) (EC 2.4.1.79) (Beta-1,3-galactosyltransferase 3) (Beta-1,3-GalTase 3) (Beta3Gal-T3) (Beta3GalT3) (b3Gal-T3) (Beta-3-Gx-T3) (Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase) (Globoside synthase) (UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase)" B3galnt1 B3galt3 Rattus norvegicus (Rat) TR38205_c2_g2_i4 Q7T3S5 B3G5A_DANRE 6.00E-06 GO:0000139; GO:0008378; GO:0016021; GO:0047256; GO:0006486 "Golgi membrane; galactosyltransferase activity; integral to membrane; lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity; protein glycosylation" IPR002659; Protein modification; protein glycosylation. "Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase A (EC 2.4.1.206) (Lactotriaosylceramide synthase A) (Lc(3)Cer synthase A) (Lc3 synthase A) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5A) (BGnT-5A) (Beta-1,3-Gn-T5A) (Beta-1,3-N-acetylglucosaminyltransferase 5A) (Beta3Gn-T5A)" b3gnt5a b3gnt5 Danio rerio (Zebrafish) (Brachydanio rerio) TR38209_c2_g1_i1 O96390 RACF1_DICDI 4.00E-63 GO:0005525; GO:0005622; GO:0016020; GO:0019953; GO:0007264 GTP binding; intracellular; membrane; sexual reproduction; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Rho-related protein racF1 racF1 DDB_G0269176 Dictyostelium discoideum (Slime mold) TR38209_c2_g1_i2 P15153 RAC2_HUMAN 2.00E-77 GO:0005525; GO:0003924; GO:0030036; GO:0007411; GO:0045453; GO:0030031; GO:0005829; GO:0005635; GO:0005886; GO:0030168; GO:0008284; GO:0010310; GO:0060263; GO:0051056; GO:0007264 GTP binding; GTPase activity; actin cytoskeleton organization; axon guidance; bone resorption; cell projection assembly; cytosol; nuclear envelope; plasma membrane; platelet activation; positive regulation of cell proliferation; regulation of hydrogen peroxide metabolic process; regulation of respiratory burst; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2) RAC2 Homo sapiens (Human) TR38209_c3_g1_i1 P48148 RHO1_DROME 9.00E-119 GO:0005525; GO:0003924; GO:0007254; GO:0016055; GO:0051017; GO:0007298; GO:0035147; GO:0005938; GO:0090254; GO:0070451; GO:0007349; GO:0030866; GO:0005856; GO:0048813; GO:0070593; GO:0007368; GO:0046663; GO:0007395; GO:0006897; GO:0007173; GO:0001737; GO:0045184; GO:0008354; GO:0007377; GO:0008347; GO:0035099; GO:0035149; GO:0045199; GO:0035006; GO:0008045; GO:0007405; GO:0016318; GO:0007422; GO:0005886; GO:0071902; GO:0007374; GO:0030589; GO:0035298; GO:0050770; GO:0051493; GO:0016476; GO:0035159; GO:0006974; GO:0007435; GO:0007264; GO:0035277; GO:0007370; GO:0007601; GO:0042060 "GTP binding; GTPase activity; JNK cascade; Wnt receptor signaling pathway; actin filament bundle assembly; border follicle cell migration; branch fusion, open tracheal system; cell cortex; cell elongation involved in imaginal disc-derived wing morphogenesis; cell hair; cellularization; cortical actin cytoskeleton organization; cytoskeleton; dendrite morphogenesis; dendrite self-avoidance; determination of left/right symmetry; dorsal closure, leading edge cell differentiation; dorsal closure, spreading of leading edge cells; endocytosis; epidermal growth factor receptor signaling pathway; establishment of imaginal disc-derived wing hair orientation; establishment of protein localization; germ cell migration; germ-band extension; glial cell migration; hemocyte migration; lumen formation, open tracheal system; maintenance of epithelial cell apical/basal polarity; melanization defense response; motor neuron axon guidance; neuroblast proliferation; ommatidial rotation; peripheral nervous system development; plasma membrane; positive regulation of protein serine/threonine kinase activity; posterior midgut invagination; pseudocleavage involved in syncytial blastoderm formation; regulation of Malpighian tubule size; regulation of axonogenesis; regulation of cytoskeleton organization; regulation of embryonic cell shape; regulation of tube length, open tracheal system; response to DNA damage stimulus; salivary gland morphogenesis; small GTPase mediated signal transduction; spiracle morphogenesis, open tracheal system; ventral furrow formation; visual perception; wound healing" IPR027417; IPR005225; IPR001806; IPR003578; Ras-like GTP-binding protein Rho1 Rho1 CG8416 Drosophila melanogaster (Fruit fly) TR38209_c3_g1_i2 P33153 CRL1_CANAW 1.00E-52 GO:0005525; GO:0005622; GO:0005886; GO:0007264 GTP binding; intracellular; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; GTP-binding RHO-like protein CRL1 RHO4 CAWG_01235 Candida albicans (strain WO-1) (Yeast) TR38209_c3_g1_i4 O42825 RHO1_CANAL 6.00E-91 GO:0006075; GO:0005525; GO:0003924; GO:0007266; GO:0005934; GO:0035690; GO:0000920; GO:0030010; GO:0030448; GO:0001411; GO:0005622; GO:0005886; GO:0004871 (1->3)-beta-D-glucan biosynthetic process; GTP binding; GTPase activity; Rho protein signal transduction; cellular bud tip; cellular response to drug; cytokinetic cell separation; establishment of cell polarity; hyphal growth; hyphal tip; intracellular; plasma membrane; signal transducer activity IPR027417; IPR005225; IPR001806; IPR003578; GTP-binding protein RHO1 RHO1 CaO19.10362 CaO19.2843 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) TR38209_c3_g1_i5 Q4R4S4 ARL8B_MACFA 4.00E-06 GO:0005525; GO:0051301; GO:0007059; GO:0031902; GO:0005765; GO:0007067; GO:0007264; GO:0005819 GTP binding; cell division; chromosome segregation; late endosome membrane; lysosomal membrane; mitosis; small GTPase mediated signal transduction; spindle IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 8B ARL8B QflA-10573 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38209_c3_g2_i1 P01122 RHO_APLCA 1.00E-121 GO:0005525; GO:0005622; GO:0005886; GO:0007264 GTP binding; intracellular; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Ras-like GTP-binding protein RHO RHO Aplysia californica (California sea hare) TR38209_c3_g2_i2 P33153 CRL1_CANAW 7.00E-53 GO:0005525; GO:0005622; GO:0005886; GO:0007264 GTP binding; intracellular; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; GTP-binding RHO-like protein CRL1 RHO4 CAWG_01235 Candida albicans (strain WO-1) (Yeast) TR38211_c1_g1_i6 Q55DH0 Y1320_DICDI 1.00E-16 GO:0006629; GO:0008081 lipid metabolic process; phosphoric diester hydrolase activity IPR017946; IPR000909; PI-PLC X domain-containing protein DDB_G0269228 DDB_G0269228 Dictyostelium discoideum (Slime mold) TR38211_c1_g1_i7 Q8BLJ3 PLCX3_MOUSE 8.00E-36 GO:0016042; GO:0008081; GO:0004871 lipid catabolic process; phosphoric diester hydrolase activity; signal transducer activity IPR017946; IPR000909; PI-PLC X domain-containing protein 3 Plcxd3 Mus musculus (Mouse) TR38212_c1_g4_i1 P58308 OX2R_MOUSE 5.00E-09 GO:0022410; GO:0007631; GO:0016021; GO:0007218; GO:0016499; GO:0017046; GO:0007200; GO:0005886 circadian sleep/wake cycle process; feeding behavior; integral to membrane; neuropeptide signaling pathway; orexin receptor activity; peptide hormone binding; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane IPR000276; IPR017452; IPR000204; IPR004060; Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Mox2r Mus musculus (Mouse) TR38212_c1_g4_i3 P47901 V1BR_HUMAN 3.00E-07 GO:0007202; GO:0007204; GO:0005768; GO:0005887; GO:0005080; GO:0001992; GO:0005000 activation of phospholipase C activity; elevation of cytosolic calcium ion concentration; endosome; integral to plasma membrane; protein kinase C binding; regulation of systemic arterial blood pressure by vasopressin; vasopressin receptor activity IPR000276; IPR017452; IPR001817; IPR000628; Vasopressin V1b receptor (V1bR) (AVPR V1b) (AVPR V3) (Antidiuretic hormone receptor 1b) (Vasopressin V3 receptor) AVPR1B AVPR3 VPR3 Homo sapiens (Human) TR38213_c0_g2_i1 Q8N556 AFAP1_HUMAN 2.00E-13 GO:0015629; GO:0005737; GO:0005925; GO:0005543 actin cytoskeleton; cytoplasm; focal adhesion; phospholipid binding IPR011993; IPR001849; Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) AFAP1 AFAP Homo sapiens (Human) TR38215_c2_g2_i1 Q6ZQ11 CHSS1_MOUSE 0 GO:0032580; GO:0050510; GO:0030206; GO:0005576; GO:0047238; GO:0016021; GO:0046872; GO:0030279 Golgi cisterna membrane; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity; chondroitin sulfate biosynthetic process; extracellular region; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity; integral to membrane; metal ion binding; negative regulation of ossification IPR008428; Chondroitin sulfate synthase 1 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 1) (Chondroitin synthase 1) (ChSy-1) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1) (N-acetylgalactosaminyltransferase 1) Chsy1 Kiaa0990 Mus musculus (Mouse) TR38216_c1_g1_i1 Q58DA6 S35A2_BOVIN 6.00E-89 GO:0000139; GO:0016021; GO:0005338; GO:0015780; GO:0005351 Golgi membrane; integral to membrane; nucleotide-sugar transmembrane transporter activity; nucleotide-sugar transport; sugar:hydrogen symporter activity IPR007271; IPR021189; IPR004689; UDP-galactose translocator (Solute carrier family 35 member A2) (UDP-galactose transporter) (UDP-Gal-Tr) (UGT) SLC35A2 Bos taurus (Bovine) TR38217_c2_g1_i1 P79996 MK09_CHICK 0 GO:0005524; GO:0007254; GO:0004707; GO:0002755; GO:0035419; GO:0005829; GO:0009790; GO:0045087; GO:0005739; GO:2001235; GO:0010628; GO:0010744; GO:0046686; GO:0035681; GO:0034134; GO:0035682; GO:0034138; GO:0034142; GO:0034146; GO:0034154 ATP binding; JNK cascade; MAP kinase activity; MyD88-dependent toll-like receptor signaling pathway; activation of MAPK activity involved in innate immune response; cytosol; embryo development; innate immune response; mitochondrion; positive regulation of apoptotic signaling pathway; positive regulation of gene expression; positive regulation of macrophage derived foam cell differentiation; response to cadmium ion; toll-like receptor 15 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 21 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 7 signaling pathway IPR011009; IPR003527; IPR008351; IPR000719; IPR002290; IPR008271; Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) MAPK9 JNK2 Gallus gallus (Chicken) TR38217_c2_g1_i2 P92208 JNK_DROME 0 GO:0005524; GO:0004705; GO:0016055; GO:0019731; GO:0030424; GO:0048675; GO:0007411; GO:0007298; GO:0071243; GO:0071276; GO:0034614; GO:0048674; GO:0005737; GO:0030425; GO:0071907; GO:0046843; GO:0007391; GO:0048615; GO:0043652; GO:0001736; GO:0046529; GO:0048803; GO:0035006; GO:0046844; GO:0043508; GO:0010508; GO:0009408; GO:0035313 "ATP binding; JUN kinase activity; Wnt receptor signaling pathway; antibacterial humoral response; axon; axon extension; axon guidance; border follicle cell migration; cellular response to arsenic-containing substance; cellular response to cadmium ion; cellular response to reactive oxygen species; collateral sprouting of injured axon; cytoplasm; dendrite; determination of digestive tract left/right asymmetry; dorsal appendage formation; dorsal closure; embryonic anterior midgut (ectodermal) morphogenesis; engulfment of apoptotic cell; establishment of planar polarity; imaginal disc fusion, thorax closure; imaginal disc-derived male genitalia morphogenesis; melanization defense response; micropyle formation; negative regulation of JUN kinase activity; positive regulation of autophagy; response to heat; wound healing, spreading of epidermal cells" IPR011009; IPR003527; IPR008351; IPR000719; IPR002290; IPR008271; Stress-activated protein kinase JNK (dJNK) (EC 2.7.11.24) (Protein basket) bsk JNK CG5680 Drosophila melanogaster (Fruit fly) TR38219_c4_g1_i1 O95251 KAT7_HUMAN 0 GO:0006260; GO:0043966; GO:0043983; GO:0043981; GO:0043982; GO:0004402; GO:0000123; GO:0006355; GO:0003700; GO:0006351; GO:0008270 P10275; Q99728; Q9P2H0; P08670 "DNA replication; histone H3 acetylation; histone H4-K12 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase activity; histone acetyltransferase complex; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR016181; IPR002717; IPR015880; IPR002515; "Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)" KAT7 HBO1 HBOa MYST2 Homo sapiens (Human) TR38219_c6_g2_i1 Q0IIH4 CHAC2_BOVIN 4.00E-40 IPR013024; IPR006840; Cation transport regulator-like protein 2 CHAC2 Bos taurus (Bovine) TR38219_c6_g2_i2 Q8WUX2 CHAC2_HUMAN 7.00E-77 IPR013024; IPR006840; Cation transport regulator-like protein 2 CHAC2 Homo sapiens (Human) TR38220_c0_g1_i1 A7Y2X0 SC6A5_XENLA 1.00E-126 GO:0016021; GO:0005328 integral to membrane; neurotransmitter:sodium symporter activity IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (xGlyT2) (Solute carrier family 6 member 5) slc6a5 glyt2 Xenopus laevis (African clawed frog) TR38222_c0_g1_i1 Q69ZC8 K1704_MOUSE 1.00E-11 IPR022226; GPALPP motifs-containing protein 1 Gpalpp1 Kiaa1704 Mus musculus (Mouse) TR38222_c0_g2_i2 Q5R863 K1704_PONAB 5.00E-17 IPR022226; GPALPP motifs-containing protein 1 GPALPP1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38222_c0_g3_i1 Q3ZBM6 K1704_BOVIN 1.00E-13 IPR022226; GPALPP motifs-containing protein 1 GPALPP1 Bos taurus (Bovine) TR38223_c0_g2_i1 Q8TBK6 ZCH10_HUMAN 8.00E-09 GO:0003676; GO:0008270 nucleic acid binding; zinc ion binding IPR001878; Zinc finger CCHC domain-containing protein 10 ZCCHC10 Homo sapiens (Human) TR38224_c0_g1_i1 Q8NCC3 PAG15_HUMAN 6.00E-61 GO:0008374; GO:0047499; GO:0006672; GO:0005576; GO:0009062; GO:0004622; GO:0005764; GO:0005739; GO:0046470; GO:0005543 O-acyltransferase activity; calcium-independent phospholipase A2 activity; ceramide metabolic process; extracellular region; fatty acid catabolic process; lysophospholipase activity; lysosome; mitochondrion; phosphatidylcholine metabolic process; phospholipid binding IPR003386; Group XV phospholipase A2 (EC 2.3.1.-) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) PLA2G15 LYPLA3 UNQ341/PRO540 Homo sapiens (Human) TR38224_c0_g1_i3 Q8NCC3 PAG15_HUMAN 3.00E-117 GO:0008374; GO:0047499; GO:0006672; GO:0005576; GO:0009062; GO:0004622; GO:0005764; GO:0005739; GO:0046470; GO:0005543 O-acyltransferase activity; calcium-independent phospholipase A2 activity; ceramide metabolic process; extracellular region; fatty acid catabolic process; lysophospholipase activity; lysosome; mitochondrion; phosphatidylcholine metabolic process; phospholipid binding IPR003386; Group XV phospholipase A2 (EC 2.3.1.-) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) PLA2G15 LYPLA3 UNQ341/PRO540 Homo sapiens (Human) TR38226_c2_g1_i1 Q94B38 GPT2_ARATH 1.00E-22 GO:0031969; GO:0015152; GO:0005315; GO:0016021; GO:0015714; GO:0015120; GO:0015979; GO:0009643; GO:0010109; GO:0009749; GO:0080167; GO:0009624; GO:0009744; GO:0071917; GO:0005774 chloroplast membrane; glucose-6-phosphate transmembrane transporter activity; inorganic phosphate transmembrane transporter activity; integral to membrane; phosphoenolpyruvate transport; phosphoglycerate transmembrane transporter activity; photosynthesis; photosynthetic acclimation; regulation of photosynthesis; response to glucose stimulus; response to karrikin; response to nematode; response to sucrose stimulus; triose-phosphate transmembrane transporter activity; vacuolar membrane IPR000620; IPR004853; IPR004696; "Glucose-6-phosphate/phosphate translocator 2, chloroplastic" GPT2 At1g61800 F8K4.1 Arabidopsis thaliana (Mouse-ear cress) TR38226_c2_g1_i2 Q9VR50 S35E1_DROME 9.00E-81 GO:0016021 integral to membrane IPR000620; IPR004853; Solute carrier family 35 member E1 homolog CG14621 Drosophila melanogaster (Fruit fly) TR38226_c3_g1_i2 Q9BMQ6 MYSP_OPIFE 3.00E-27 GO:0003774; GO:0030016; GO:0032982 motor activity; myofibril; myosin filament IPR002928; Paramyosin (Fragment) Opisthorchis felineus TR38226_c3_g1_i3 P24733 MYS_AEQIR 4.00E-143 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR015650; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, striated muscle" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR38228_c1_g1_i2 Q557G3 TPPC1_DICDI 4.00E-34 GO:0006888; GO:0005794; GO:0005801; GO:0005783 ER to Golgi vesicle-mediated transport; Golgi apparatus; cis-Golgi network; endoplasmic reticulum IPR011012; IPR007233; Trafficking protein particle complex subunit 1 trappc1-1 DDB_G0273467; trappc1-2 DDB_G0273579 Dictyostelium discoideum (Slime mold) TR38228_c1_g1_i3 Q2KMM2 TPPC1_RAT 2.00E-66 GO:0006888; GO:0005794; GO:0030008; GO:0005801; GO:0005783 ER to Golgi vesicle-mediated transport; Golgi apparatus; TRAPP complex; cis-Golgi network; endoplasmic reticulum IPR011012; IPR007233; Trafficking protein particle complex subunit 1 Trappc1 Rattus norvegicus (Rat) TR38228_c1_g1_i4 Q69BT7 TPPC4_RAT 8.00E-10 GO:0006888; GO:0005795; GO:0030008; GO:0005801; GO:0030425; GO:0016358; GO:0005783; GO:0008021 ER to Golgi vesicle-mediated transport; Golgi stack; TRAPP complex; cis-Golgi network; dendrite; dendrite development; endoplasmic reticulum; synaptic vesicle IPR011012; IPR007233; Trafficking protein particle complex subunit 4 (Synbindin) Trappc4 Sbdn Rattus norvegicus (Rat) TR38229_c0_g1_i1 Q4KLZ6 DHAK_RAT 2.00E-167 GO:0005524; GO:0034012; GO:0006071; GO:0004371; GO:0046872; GO:0050354 ATP binding; FAD-AMP lyase (cyclizing) activity; glycerol metabolic process; glycerone kinase activity; metal ion binding; triokinase activity IPR004006; IPR012734; IPR004007; Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) [Includes: ATP-dependent dihydroxyacetone kinase (DHA kinase) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase) (Triokinase) (Triose kinase); FAD-AMP lyase (cyclizing) (EC 4.6.1.15) (FAD-AMP lyase (cyclic FMN forming)) (FMN cyclase)] Dak Rattus norvegicus (Rat) TR38229_c0_g1_i2 Q55EE0 DHAK_DICDI 5.00E-91 GO:0005524; GO:0006071; GO:0004371; GO:0016829; GO:0050354 ATP binding; glycerol metabolic process; glycerone kinase activity; lyase activity; triokinase activity IPR004006; IPR004007; Probable dihydroxyacetone kinase (DHA kinase) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase) (Triokinase) (Triose kinase) dhak dak DDB_G0269274 Dictyostelium discoideum (Slime mold) TR38229_c0_g1_i4 Q4KLZ6 DHAK_RAT 4.00E-08 GO:0005524; GO:0034012; GO:0006071; GO:0004371; GO:0046872; GO:0050354 ATP binding; FAD-AMP lyase (cyclizing) activity; glycerol metabolic process; glycerone kinase activity; metal ion binding; triokinase activity IPR004006; IPR012734; IPR004007; Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) [Includes: ATP-dependent dihydroxyacetone kinase (DHA kinase) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase) (Triokinase) (Triose kinase); FAD-AMP lyase (cyclizing) (EC 4.6.1.15) (FAD-AMP lyase (cyclic FMN forming)) (FMN cyclase)] Dak Rattus norvegicus (Rat) TR38230_c0_g1_i1 Q291E4 VIR_DROPS 9.00E-42 GO:0000375; GO:0006397; GO:0005634; GO:0007539; GO:0000381 "RNA splicing, via transesterification reactions; mRNA processing; nucleus; primary sex determination, soma; regulation of alternative mRNA splicing, via spliceosome" IPR026736; Protein virilizer vir GA17481 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR38230_c1_g2_i1 P45978 SCD6_YEAST 1.00E-07 GO:0000932; GO:0033962; GO:0010494; GO:0031370; GO:0003729; GO:0045947; GO:0034063 cytoplasmic mRNA processing body; cytoplasmic mRNA processing body assembly; cytoplasmic stress granule; eukaryotic initiation factor 4G binding; mRNA binding; negative regulation of translational initiation; stress granule assembly IPR025762; IPR019050; IPR025761; IPR025609; IPR010920; IPR025768; Protein SCD6 SCD6 YPR129W P9659.10 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR38230_c1_g2_i2 Q5R4R4 LS14A_PONAB 5.00E-36 GO:0039529; GO:0000932; GO:0033962; GO:0010494; GO:0003690; GO:0003725; GO:0007275; GO:0060340; GO:0006417; GO:0003727 RIG-I signaling pathway; cytoplasmic mRNA processing body; cytoplasmic mRNA processing body assembly; cytoplasmic stress granule; double-stranded DNA binding; double-stranded RNA binding; multicellular organismal development; positive regulation of type I interferon-mediated signaling pathway; regulation of translation; single-stranded RNA binding IPR025762; IPR019050; IPR025761; IPR025609; IPR010920; IPR025768; Protein LSM14 homolog A (Protein FAM61A) (RNA-associated protein 55A) LSM14A FAM61A RAP55A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38230_c1_g2_i4 P45978 SCD6_YEAST 9.00E-08 GO:0000932; GO:0033962; GO:0010494; GO:0031370; GO:0003729; GO:0045947; GO:0034063 cytoplasmic mRNA processing body; cytoplasmic mRNA processing body assembly; cytoplasmic stress granule; eukaryotic initiation factor 4G binding; mRNA binding; negative regulation of translational initiation; stress granule assembly IPR025762; IPR019050; IPR025761; IPR025609; IPR010920; IPR025768; Protein SCD6 SCD6 YPR129W P9659.10 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR38230_c1_g2_i6 Q8AVJ2 L14AB_XENLA 2.00E-35 GO:0017151; GO:0003723; GO:0005737; GO:0007275; GO:0017148; GO:0030529 DEAD/H-box RNA helicase binding; RNA binding; cytoplasm; multicellular organismal development; negative regulation of translation; ribonucleoprotein complex IPR025762; IPR019050; IPR025761; IPR025609; IPR010920; IPR025768; Protein LSM14 homolog A-B (RNA-associated protein 55A-B) (RAP55A-B) lsm14a-b rap55a-b Xenopus laevis (African clawed frog) TR38231_c0_g1_i1 Q6GPJ4 RMTL1_XENLA 2.00E-65 GO:0003723; GO:0001510; GO:0008173; GO:0006396 RNA binding; RNA methylation; RNA methyltransferase activity; RNA processing IPR001537; IPR013123; RNA methyltransferase-like protein 1 (EC 2.1.1.-) rnmtl1 Xenopus laevis (African clawed frog) TR38231_c0_g1_i2 Q5ND52 RMTL1_MOUSE 3.00E-53 GO:0003723; GO:0001510; GO:0008173; GO:0006396; GO:0005739 RNA binding; RNA methylation; RNA methyltransferase activity; RNA processing; mitochondrion IPR001537; IPR013123; RNA methyltransferase-like protein 1 (EC 2.1.1.-) Rnmtl1 Mus musculus (Mouse) TR38232_c5_g1_i1 A8CVX7 TTLL6_DANRE 1.00E-27 GO:0030030; GO:0036064; GO:0005737; GO:0016874; GO:0018095; GO:0015631 cell projection organization; cilium basal body; cytoplasm; ligase activity; protein polyglutamylation; tubulin binding IPR004344; Tubulin polyglutamylase ttll6 (EC 6.-.-.-) (Tubulin tyrosine ligase-like family member 6) ttll6 Danio rerio (Zebrafish) (Brachydanio rerio) TR38234_c2_g1_i1 P23919 KTHY_HUMAN 3.00E-47 GO:0005524; GO:0007049; GO:0008283; GO:0071363; GO:0005829; GO:0006233; GO:0006235; GO:0005758; GO:0005759; GO:0045445; GO:0015949; GO:0050145; GO:0046686; GO:0043627; GO:0004798 ATP binding; cell cycle; cell proliferation; cellular response to growth factor stimulus; cytosol; dTDP biosynthetic process; dTTP biosynthetic process; mitochondrial intermembrane space; mitochondrial matrix; myoblast differentiation; nucleobase-containing small molecule interconversion; nucleoside phosphate kinase activity; response to cadmium ion; response to estrogen stimulus; thymidylate kinase activity IPR027417; IPR018095; IPR018094; Pyrimidine metabolism; dTTP biosynthesis. Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) DTYMK CDC8 TMPK TYMK Homo sapiens (Human) TR38234_c2_g1_i2 P23919 KTHY_HUMAN 9.00E-42 GO:0005524; GO:0007049; GO:0008283; GO:0071363; GO:0005829; GO:0006233; GO:0006235; GO:0005758; GO:0005759; GO:0045445; GO:0015949; GO:0050145; GO:0046686; GO:0043627; GO:0004798 ATP binding; cell cycle; cell proliferation; cellular response to growth factor stimulus; cytosol; dTDP biosynthetic process; dTTP biosynthetic process; mitochondrial intermembrane space; mitochondrial matrix; myoblast differentiation; nucleobase-containing small molecule interconversion; nucleoside phosphate kinase activity; response to cadmium ion; response to estrogen stimulus; thymidylate kinase activity IPR027417; IPR018095; IPR018094; Pyrimidine metabolism; dTTP biosynthesis. Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) DTYMK CDC8 TMPK TYMK Homo sapiens (Human) TR38234_c2_g1_i3 Q22018 KTHY_CAEEL 2.00E-21 GO:0005524; GO:0006233; GO:0006235; GO:0004798 ATP binding; dTDP biosynthetic process; dTTP biosynthetic process; thymidylate kinase activity IPR027417; IPR018095; IPR018094; Pyrimidine metabolism; dTTP biosynthesis. Probable thymidylate kinase (EC 2.7.4.9) (dTMP kinase) R53.2 Caenorhabditis elegans TR38234_c2_g1_i5 O59366 KTHY_PYRHO 4.00E-11 GO:0005524; GO:0006233; GO:0006235; GO:0004798 ATP binding; dTDP biosynthetic process; dTTP biosynthetic process; thymidylate kinase activity IPR027417; IPR018095; IPR018094; Probable thymidylate kinase (EC 2.7.4.9) (dTMP kinase) tmk PH1695 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) TR38234_c2_g2_i1 Q91FS1 KTHY_IIV6 4.00E-27 GO:0005524; GO:0006233; GO:0006235; GO:0004798 ATP binding; dTDP biosynthetic process; dTTP biosynthetic process; thymidylate kinase activity IPR027417; IPR018095; IPR018094; Pyrimidine metabolism; dTTP biosynthesis. Putative thymidylate kinase 251L (EC 2.7.4.9) (dTMP kinase) IIV6-251L Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) TR38234_c2_g2_i2 O67099 KTHY_AQUAE 1.00E-06 GO:0005524; GO:0006233; GO:0006235; GO:0004798 ATP binding; dTDP biosynthetic process; dTTP biosynthetic process; thymidylate kinase activity IPR027417; IPR018095; IPR018094; Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) tmk aq_969 Aquifex aeolicus (strain VF5) TR38235_c0_g1_i1 P12400 CTL2B_MOUSE 2.00E-10 GO:0004869; GO:0008234 cysteine-type endopeptidase inhibitor activity; cysteine-type peptidase activity IPR013128; IPR013201; Protein CTLA-2-beta (Cytotoxic T-lymphocyte-associated protein 2-beta) Ctla2b Mus musculus (Mouse) TR38235_c0_g2_i2 P06797 CATL1_MOUSE 2.00E-94 GO:0060008; GO:0004177; GO:0048102; GO:0009267; GO:0004197; GO:0046697; GO:0009897; GO:0042393; GO:0005764; GO:0005902; GO:0010259; GO:0021675; GO:0043005; GO:0005730; GO:0042277; GO:0043204; GO:0016485; GO:0006508; GO:2000249; GO:0051384; GO:0009749; GO:0034698; GO:0007283 Sertoli cell differentiation; aminopeptidase activity; autophagic cell death; cellular response to starvation; cysteine-type endopeptidase activity; decidualization; external side of plasma membrane; histone binding; lysosome; microvillus; multicellular organismal aging; nerve development; neuron projection; nucleolus; peptide binding; perikaryon; protein processing; proteolysis; regulation of actin cytoskeleton reorganization; response to glucocorticoid stimulus; response to glucose stimulus; response to gonadotropin stimulus; spermatogenesis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L1 (EC 3.4.22.15) (Cathepsin L) (Major excreted protein) (MEP) (p39 cysteine proteinase) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain] Ctsl Ctsl1 Mus musculus (Mouse) TR38235_c0_g2_i3 P09648 CATL1_CHICK 2.00E-99 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; Cathepsin L1 (EC 3.4.22.15) (Cathepsin L) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain] (Fragments) CTSL CTSL1 Gallus gallus (Chicken) TR38235_c0_g2_i5 Q26636 CATL_SARPE 6.00E-106 GO:0030154; GO:0008234; GO:0005764; GO:0007275; GO:0006508 cell differentiation; cysteine-type peptidase activity; lysosome; multicellular organismal development; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) TR38236_c3_g3_i3 Q96PY6 NEK1_HUMAN 2.00E-15 GO:0005524; GO:0051301; GO:0042384; GO:0046872; GO:0007067; GO:0031965; GO:0005730; GO:0018108; GO:0000242; GO:0004672; GO:0004674; GO:0004713; GO:0006974; GO:0010212 Q99689; Q9UHY8 ATP binding; cell division; cilium assembly; metal ion binding; mitosis; nuclear membrane; nucleolus; peptidyl-tyrosine phosphorylation; pericentriolar material; protein kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; response to DNA damage stimulus; response to ionizing radiation IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) NEK1 KIAA1901 Homo sapiens (Human) TR38237_c1_g1_i1 Q08EJ0 PL8L1_MOUSE 2.00E-15 IPR006461; PLAC8-like protein 1 Plac8l1 Mus musculus (Mouse) TR38237_c1_g1_i4 Q9NZF1 PLAC8_HUMAN 7.00E-14 GO:0050873; GO:0003682; GO:0042742; GO:0043066; GO:0040015; GO:0008284; GO:0045944; GO:0009409 brown fat cell differentiation; chromatin binding; defense response to bacterium; negative regulation of apoptotic process; negative regulation of multicellular organism growth; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; response to cold IPR006461; Placenta-specific gene 8 protein (Protein C15) PLAC8 BM-004 Homo sapiens (Human) TR38238_c2_g1_i3 Q9H479 FN3K_HUMAN 2.00E-49 GO:0030387; GO:0030393 fructosamine-3-kinase activity; fructoselysine metabolic process IPR016477; IPR011009; Fructosamine-3-kinase (EC 2.7.1.-) FN3K Homo sapiens (Human) TR38238_c2_g1_i4 A2XBT1 FN3KR_ORYSI 3.00E-21 GO:0015996; GO:0009507; GO:0016301; GO:0005739 chlorophyll catabolic process; chloroplast; kinase activity; mitochondrion IPR016477; IPR011009; "Protein-ribulosamine 3-kinase, chloroplastic (EC 2.7.1.172) (Fructosamine 3-kinase-related protein)" OsI_09747 Oryza sativa subsp. indica (Rice) TR38238_c2_g1_i7 Q9H479 FN3K_HUMAN 1.00E-49 GO:0030387; GO:0030393 fructosamine-3-kinase activity; fructoselysine metabolic process IPR016477; IPR011009; Fructosamine-3-kinase (EC 2.7.1.-) FN3K Homo sapiens (Human) TR38238_c2_g2_i1 P74594 Y1563_SYNY3 3.00E-18 GO:0016301 kinase activity IPR016477; IPR011009; Uncharacterized protein slr1563 slr1563 Synechocystis sp. (strain PCC 6803 / Kazusa) TR38238_c2_g2_i2 Q9HA64 KT3K_HUMAN 6.00E-47 GO:0016301 kinase activity IPR016477; IPR011009; Ketosamine-3-kinase (EC 2.7.1.-) (Fructosamine-3-kinase-related protein) (FN3K-RP) (FN3K-related protein) FN3KRP Homo sapiens (Human) TR38239_c0_g1_i1 P90597 DLDH_TRYCR 6.00E-159 GO:0045454; GO:0004148; GO:0050660; GO:0006096 cell redox homeostasis; dihydrolipoyl dehydrogenase activity; flavin adenine dinucleotide binding; glycolysis IPR016156; IPR013027; IPR006258; IPR004099; IPR023753; IPR012999; IPR001327; Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) LPD Trypanosoma cruzi TR38239_c0_g1_i2 P08662 MERA_SERMA 2.00E-17 GO:0050661; GO:0045454; GO:0050787; GO:0050660; GO:0016152; GO:0045340; GO:0030001; GO:0016668 "NADP binding; cell redox homeostasis; detoxification of mercury ion; flavin adenine dinucleotide binding; mercury (II) reductase activity; mercury ion binding; metal ion transport; oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor" IPR016156; IPR017969; IPR006121; IPR000815; IPR021179; IPR004099; IPR023753; IPR012999; IPR001327; Mercuric reductase (EC 1.16.1.1) (Hg(II) reductase) (Fragments) merA Serratia marcescens TR38239_c0_g1_i3 P09623 DLDH_PIG 0 GO:0045454; GO:0004148; GO:0050660; GO:0005759 cell redox homeostasis; dihydrolipoyl dehydrogenase activity; flavin adenine dinucleotide binding; mitochondrial matrix IPR016156; IPR013027; IPR006258; IPR004099; IPR023753; IPR012999; IPR001327; "Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase)" DLD LAD Sus scrofa (Pig) TR38239_c0_g1_i4 O00087 DLDH_SCHPO 0 GO:0006103; GO:0000082; GO:0006564; GO:0006086; GO:0045454; GO:0004148; GO:0015036; GO:0050660; GO:0005960; GO:0019464; GO:0006550; GO:0006552; GO:0042645; GO:0009353; GO:0005967; GO:0004739; GO:0006574 2-oxoglutarate metabolic process; G1/S transition of mitotic cell cycle; L-serine biosynthetic process; acetyl-CoA biosynthetic process from pyruvate; cell redox homeostasis; dihydrolipoyl dehydrogenase activity; disulfide oxidoreductase activity; flavin adenine dinucleotide binding; glycine cleavage complex; glycine decarboxylation via glycine cleavage system; isoleucine catabolic process; leucine catabolic process; mitochondrial nucleoid; mitochondrial oxoglutarate dehydrogenase complex; mitochondrial pyruvate dehydrogenase complex; pyruvate dehydrogenase (acetyl-transferring) activity; valine catabolic process IPR016156; IPR013027; IPR006258; IPR004099; IPR023753; IPR012999; IPR001327; "Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (DLDH)" dld1 SPAC1002.09c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38240_c6_g1_i2 Q8ISH7 FCAP_APLCA 7.00E-18 GO:0005576; GO:0007218 extracellular region; neuropeptide signaling pathway Feeding circuit activating peptides (FCAP) [Cleaved into: Feeding circuit activating peptide a (FCAPa); Feeding circuit activating peptide b (FCAPb); Feeding circuit activating peptide c (FCAPc); Feeding circuit activating peptide d (FCAPd); Feeding circuit activating peptide e (FCAPe); Feeding circuit activating peptide f (FCAPf); Feeding circuit activating peptide g (FCAPg); Feeding circuit activating peptide h (FCAPh)] Aplysia californica (California sea hare) TR38243_c2_g1_i4 Q924H0 NPFF2_MOUSE 6.00E-09 GO:0015629; GO:0005887; GO:0008188; GO:0007218; GO:0043408; GO:0045761; GO:2000479 actin cytoskeleton; integral to plasma membrane; neuropeptide receptor activity; neuropeptide signaling pathway; regulation of MAPK cascade; regulation of adenylate cyclase activity; regulation of cAMP-dependent protein kinase activity IPR000276; IPR017452; IPR005395; IPR005397; Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide NPFF receptor) Npffr2 Gpr74 Npff2 Mus musculus (Mouse) TR38244_c0_g2_i1 Q8NBZ7 UXS1_HUMAN 7.00E-170 GO:0032580; GO:0033320; GO:0048040; GO:0050662; GO:0016021; GO:0005739 Golgi cisterna membrane; UDP-D-xylose biosynthetic process; UDP-glucuronate decarboxylase activity; coenzyme binding; integral to membrane; mitochondrion IPR001509; IPR016040; IPR021761; Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1. UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1) UXS1 UNQ2538/PRO6079 Homo sapiens (Human) TR38244_c0_g2_i3 Q8NBZ7 UXS1_HUMAN 1.00E-49 GO:0032580; GO:0033320; GO:0048040; GO:0050662; GO:0016021; GO:0005739 Golgi cisterna membrane; UDP-D-xylose biosynthetic process; UDP-glucuronate decarboxylase activity; coenzyme binding; integral to membrane; mitochondrion IPR001509; IPR016040; IPR021761; Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1. UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1) UXS1 UNQ2538/PRO6079 Homo sapiens (Human) TR38245_c0_g1_i2 Q08C93 ABD12_DANRE 1.00E-90 GO:0047372; GO:0016021 acylglycerol lipase activity; integral to membrane IPR026605; Monoacylglycerol lipase ABHD12 (EC 3.1.1.23) (Abhydrolase domain-containing protein 12) abhd12 si:ch211-79l10.2 zgc:153367 Danio rerio (Zebrafish) (Brachydanio rerio) TR38245_c0_g1_i4 Q6AYT7 ABD12_RAT 1.00E-89 GO:0047372; GO:0032281 acylglycerol lipase activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex IPR026605; Monoacylglycerol lipase ABHD12 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 12) Abhd12 Rattus norvegicus (Rat) TR38245_c0_g1_i5 Q8XA81 YHFR_ECO57 6.00E-16 GO:0016021 integral to membrane Uncharacterized protein YfhR yhfR Z3802 ECs3400 Escherichia coli O157:H7 TR38245_c0_g1_i7 Q8N2K0 ABD12_HUMAN 5.00E-90 GO:0047372; GO:0032281 acylglycerol lipase activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex IPR026605; Monoacylglycerol lipase ABHD12 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 12) ABHD12 C20orf22 Homo sapiens (Human) TR38246_c1_g1_i6 Q16629 SRSF7_HUMAN 9.00E-18 GO:0003723; GO:0031124; GO:0006406; GO:0000398; GO:0048025; GO:0005654; GO:0000166; GO:0006369; GO:0008270 Q9UBU9; Q7Z6E9; Q9JKL7; Q96SB4; P78362 "RNA binding; mRNA 3'-end processing; mRNA export from nucleus; mRNA splicing, via spliceosome; negative regulation of mRNA splicing, via spliceosome; nucleoplasm; nucleotide binding; termination of RNA polymerase II transcription; zinc ion binding" IPR012677; IPR000504; IPR001878; "Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)" SRSF7 SFRS7 Homo sapiens (Human) TR38247_c0_g1_i1 P36609 NCS2_CAEEL 2.00E-27 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Neuronal calcium sensor 2 (NCS-2) ncs-2 F10G8.5 Caenorhabditis elegans TR38247_c0_g1_i3 Q86A72 Y4781_DICDI 1.00E-10 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Recoverin family protein DDB_G0274781 DDB_G0274781 Dictyostelium discoideum (Slime mold) TR38247_c0_g1_i6 P36609 NCS2_CAEEL 8.00E-28 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Neuronal calcium sensor 2 (NCS-2) ncs-2 F10G8.5 Caenorhabditis elegans TR38248_c2_g1_i1 C3XRY1 NO66_BRAFL 0 GO:0051864; GO:0032453; GO:0005506; GO:0045892; GO:0005634; GO:0006351 "histone demethylase activity (H3-K36 specific); histone demethylase activity (H3-K4 specific); iron ion binding; negative regulation of transcription, DNA-dependent; nucleus; transcription, DNA-dependent" IPR003347; IPR013109; Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 (EC 1.14.11.-) (EC 1.14.11.27) (Histone lysine demethylase NO66) BRAFLDRAFT_123918 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR38249_c1_g1_i1 Q63372 NRX1A_RAT 5.00E-16 GO:0033130; GO:0030534; GO:0005246; GO:0005509; GO:0007155; GO:0050839; GO:0030054; GO:0009986; GO:0097116; GO:0016021; GO:0007612; GO:0097118; GO:0097109; GO:0050885; GO:0007269; GO:2000463; GO:0051965; GO:0090129; GO:0051968; GO:0097119; GO:0097104; GO:0060134; GO:0042734; GO:0051290; GO:2000821 "acetylcholine receptor binding; adult behavior; calcium channel regulator activity; calcium ion binding; cell adhesion; cell adhesion molecule binding; cell junction; cell surface; gephyrin clustering; integral to membrane; learning; neuroligin clustering; neuroligin family protein binding; neuromuscular process controlling balance; neurotransmitter secretion; positive regulation of excitatory postsynaptic membrane potential; positive regulation of synapse assembly; positive regulation of synapse maturation; positive regulation of synaptic transmission, glutamatergic; postsynaptic density protein 95 clustering; postsynaptic membrane assembly; prepulse inhibition; presynaptic membrane; protein heterotetramerization; regulation of grooming behavior" IPR008985; IPR013320; IPR000742; IPR000152; IPR001791; IPR003585; IPR027158; IPR027789; Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) Nrxn1 Rattus norvegicus (Rat) TR38250_c0_g1_i1 Q9C0B9 ZCHC2_HUMAN 6.00E-20 GO:0007154; GO:0005737; GO:0003676; GO:0035091; GO:0008270 cell communication; cytoplasm; nucleic acid binding; phosphatidylinositol binding; zinc ion binding IPR001683; IPR001878; Zinc finger CCHC domain-containing protein 2 ZCCHC2 KIAA1744 Homo sapiens (Human) TR38253_c0_g1_i1 P30284 CG21_EMENI 4.00E-63 GO:0000086; GO:0051301; GO:0016538; GO:0007067; GO:0005730; GO:0000079; GO:0005816 G2/M transition of mitotic cell cycle; cell division; cyclin-dependent protein serine/threonine kinase regulator activity; mitosis; nucleolus; regulation of cyclin-dependent protein serine/threonine kinase activity; spindle pole body IPR013763; IPR014400; IPR004367; IPR006671; G2/mitotic-specific cyclin-B nimE AN3648 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR38253_c0_g1_i2 P24862 CCNB_PATVU 0 GO:0051301; GO:0007067; GO:0005634; GO:0000079 cell division; mitosis; nucleus; regulation of cyclin-dependent protein serine/threonine kinase activity IPR013763; IPR014400; IPR004367; IPR006671; G2/mitotic-specific cyclin-B Patella vulgata (Common limpet) TR38253_c0_g3_i1 P13952 CCNB_SPISO 0 GO:0051301; GO:0007067; GO:0005634; GO:0000079 cell division; mitosis; nucleus; regulation of cyclin-dependent protein serine/threonine kinase activity IPR013763; IPR014400; IPR004367; IPR006671; G2/mitotic-specific cyclin-B Spisula solidissima (Atlantic surf-clam) TR38254_c0_g1_i1 P69326 UBIQ_WHEAT 1.00E-06 GO:0005737; GO:0005634 cytoplasm; nucleus IPR019956; IPR019954; IPR000626; Ubiquitin Triticum aestivum (Wheat) TR38254_c0_g2_i2 Q15459 SF3A1_HUMAN 2.00E-126 GO:0003723; GO:0005684; GO:0071013; GO:0000389; GO:0005654 Q9BXW4; O75400; P98175; Q15428; Q12874; P08047 RNA binding; U2-type spliceosomal complex; catalytic step 2 spliceosome; mRNA 3'-splice site recognition; nucleoplasm IPR022030; IPR000061; IPR000626; Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114) SF3A1 SAP114 Homo sapiens (Human) TR38256_c1_g1_i11 Q9NS18 GLRX2_HUMAN 8.00E-27 GO:0051537; GO:0042262; GO:0006915; GO:0008794; GO:0030154; GO:0045454; GO:0009055; GO:0015038; GO:0006749; GO:0046872; GO:0005739; GO:0005634; GO:0003756; GO:0015035; GO:0009966; GO:0006355; GO:0042542; GO:0010033; GO:0051775; GO:0009266 "2 iron, 2 sulfur cluster binding; DNA protection; apoptotic process; arsenate reductase (glutaredoxin) activity; cell differentiation; cell redox homeostasis; electron carrier activity; glutathione disulfide oxidoreductase activity; glutathione metabolic process; metal ion binding; mitochondrion; nucleus; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; regulation of signal transduction; regulation of transcription, DNA-dependent; response to hydrogen peroxide; response to organic substance; response to redox state; response to temperature stimulus" IPR002109; IPR011899; IPR014025; IPR015450; IPR012336; "Glutaredoxin-2, mitochondrial" GLRX2 GRX2 CGI-133 Homo sapiens (Human) TR38256_c1_g1_i13 Q923X4 GLRX2_MOUSE 1.00E-26 GO:0051537; GO:0045454; GO:0009055; GO:0046872; GO:0005739; GO:0005634; GO:0015035; GO:0042542; GO:0010033 "2 iron, 2 sulfur cluster binding; cell redox homeostasis; electron carrier activity; metal ion binding; mitochondrion; nucleus; protein disulfide oxidoreductase activity; response to hydrogen peroxide; response to organic substance" IPR002109; IPR011899; IPR014025; IPR015450; IPR012336; "Glutaredoxin-2, mitochondrial" Glrx2 Grx2 Mus musculus (Mouse) TR38256_c1_g1_i3 Q923X4 GLRX2_MOUSE 1.00E-26 GO:0051537; GO:0045454; GO:0009055; GO:0046872; GO:0005739; GO:0005634; GO:0015035; GO:0042542; GO:0010033 "2 iron, 2 sulfur cluster binding; cell redox homeostasis; electron carrier activity; metal ion binding; mitochondrion; nucleus; protein disulfide oxidoreductase activity; response to hydrogen peroxide; response to organic substance" IPR002109; IPR011899; IPR014025; IPR015450; IPR012336; "Glutaredoxin-2, mitochondrial" Glrx2 Grx2 Mus musculus (Mouse) TR38256_c1_g1_i4 Q8R066 C1QT4_MOUSE 1.00E-07 GO:0005615 extracellular space IPR001073; IPR008983; Complement C1q tumor necrosis factor-related protein 4 C1qtnf4 Mus musculus (Mouse) TR38258_c2_g1_i1 P51589 CP2J2_HUMAN 1.00E-83 GO:0008405; GO:0008404; GO:0070330; GO:0005789; GO:0019373; GO:0020037; GO:0005506; GO:0071614; GO:0043651; GO:0008016; GO:0006805 "arachidonic acid 11,12-epoxygenase activity; arachidonic acid 14,15-epoxygenase activity; aromatase activity; endoplasmic reticulum membrane; epoxygenase P450 pathway; heme binding; iron ion binding; linoleic acid epoxygenase activity; linoleic acid metabolic process; regulation of heart contraction; xenobiotic metabolic process" IPR001128; IPR017972; IPR002401; IPR008071; Cytochrome P450 2J2 (EC 1.14.14.1) (Arachidonic acid epoxygenase) (CYPIIJ2) CYP2J2 Homo sapiens (Human) TR38258_c2_g1_i2 O55071 CP2BJ_MOUSE 9.00E-81 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; IPR008068; Cytochrome P450 2B19 (EC 1.14.14.1) (CYPIIB19) Cyp2b19 Mus musculus (Mouse) TR38258_c2_g1_i3 P54781 ERG5_YEAST 9.00E-07 GO:0000249; GO:0006696; GO:0020037; GO:0005506; GO:0004497 C-22 sterol desaturase activity; ergosterol biosynthetic process; heme binding; iron ion binding; monooxygenase activity IPR001128; IPR017972; IPR002403; Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 4/5. Cytochrome P450 61 (EC 1.14.-.-) (C-22 sterol desaturase) ERG5 CYP61 YMR015C YM9711.02C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR38258_c2_g1_i4 P12394 CP17A_CHICK 2.00E-48 GO:0047442; GO:0020037; GO:0042446; GO:0005506; GO:0016020; GO:0004508; GO:0006694; GO:0008202 17-alpha-hydroxyprogesterone aldolase activity; heme binding; hormone biosynthetic process; iron ion binding; membrane; steroid 17-alpha-monooxygenase activity; steroid biosynthetic process; steroid metabolic process IPR001128; IPR017972; IPR002401; Lipid metabolism; steroid biosynthesis. "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.99.9) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Gallus gallus (Chicken) TR38258_c2_g1_i5 P52786 CP2J1_RABIT 5.00E-80 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; IPR008071; Cytochrome P450 2J1 (EC 1.14.14.1) (CYPIIJ1) (Cytochrome P-450IB) CYP2J1 Oryctolagus cuniculus (Rabbit) TR38258_c2_g1_i8 Q54F47 C513C_DICDI 3.00E-14 GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705 "heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR002401; Probable cytochrome P450 513C1 (EC 1.14.-.-) cyp513C1 DDB_G0291105 Dictyostelium discoideum (Slime mold) TR38258_c2_g1_i9 O18963 CP2E1_BOVIN 9.00E-19 GO:0005789; GO:0020037; GO:0005506; GO:0016709; GO:0016712 "endoplasmic reticulum membrane; heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen" IPR001128; IPR017972; IPR002401; IPR008070; Cytochrome P450 2E1 (EC 1.14.13.-) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) CYP2E1 CYP2E Bos taurus (Bovine) TR38259_c0_g1_i3 Q9BZE9 ASPC1_HUMAN 1.00E-42 GO:0005829; GO:0012505; GO:0019898; GO:0042593; GO:0009898; GO:0006886; GO:0005634; GO:0048471; GO:0046324; GO:0012506 P55072 cytosol; endomembrane system; extrinsic to membrane; glucose homeostasis; internal side of plasma membrane; intracellular protein transport; nucleus; perinuclear region of cytoplasm; regulation of glucose import; vesicle membrane IPR021569; IPR001012; Tether containing UBX domain for GLUT4 (Alveolar soft part sarcoma chromosomal region candidate gene 1 protein) (Alveolar soft part sarcoma locus) (Renal papillary cell carcinoma protein 17) (UBX domain-containing protein 9) ASPSCR1 ASPL RCC17 TUG UBXD9 UBXN9 Homo sapiens (Human) TR38259_c0_g1_i4 Q99PL6 UBXN6_MOUSE 2.00E-09 GO:0005737; GO:0005815; GO:0005730 cytoplasm; microtubule organizing center; nucleolus IPR018997; IPR001012; UBX domain-containing protein 6 (UBX domain-containing protein 1) Ubxn6 Ubxd1 Ubxdc2 Mus musculus (Mouse) TR38260_c0_g1_i2 Q6GVH4 GGNB2_CHICK 9.00E-161 GO:0030154; GO:0005737; GO:0007275; GO:0007283 cell differentiation; cytoplasm; multicellular organismal development; spermatogenesis IPR026073; Gametogenetin-binding protein 2 (Protein ZNF403) GGNBP2 ZNF403 RCJMB04_15h5 Gallus gallus (Chicken) TR38260_c0_g1_i4 Q6GVH4 GGNB2_CHICK 1.00E-160 GO:0030154; GO:0005737; GO:0007275; GO:0007283 cell differentiation; cytoplasm; multicellular organismal development; spermatogenesis IPR026073; Gametogenetin-binding protein 2 (Protein ZNF403) GGNBP2 ZNF403 RCJMB04_15h5 Gallus gallus (Chicken) TR38261_c0_g1_i3 Q6DFF7 ENC2_XENLA 3.00E-10 GO:0031463; GO:0042787; GO:0006446 Cul3-RING ubiquitin ligase complex; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of translational initiation IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 25 (Ectoderm-neural cortex protein 2) (ENC-2) klhl25 enc2 Xenopus laevis (African clawed frog) TR38262_c0_g1_i1 Q3THS6 METK2_MOUSE 0 GO:0005524; GO:0006556; GO:0046872; GO:0004478; GO:0006730 ATP binding; S-adenosylmethionine biosynthetic process; metal ion binding; methionine adenosyltransferase activity; one-carbon metabolic process IPR022631; IPR022630; IPR022629; IPR022628; IPR002133; IPR022636; Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) Mat2a Mus musculus (Mouse) TR38263_c2_g1_i1 Q5F471 PP6R3_CHICK 3.00E-179 IPR016024; IPR007587; Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) PPP6R3 PP6R3 SAPS3 RCJMB04_2j4 Gallus gallus (Chicken) TR38264_c2_g3_i1 P35992 PTP10_DROME 3.00E-72 GO:0045177; GO:0030424; GO:0007417; GO:0016021; GO:0007616; GO:0008045; GO:0007424; GO:0005886; GO:0005001 apical part of cell; axon; central nervous system development; integral to membrane; long-term memory; motor neuron axon guidance; open tracheal system development; plasma membrane; transmembrane receptor protein tyrosine phosphatase activity IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase 10D (EC 3.1.3.48) (Receptor-linked protein-tyrosine phosphatase 10D) (DPTP10D) Ptp10D CG1817 Drosophila melanogaster (Fruit fly) TR38264_c2_g3_i2 P49446 PTPRE_MOUSE 5.00E-60 GO:0005737; GO:0016021; GO:0045111; GO:0046627; GO:0005634; GO:0005886; GO:0042803; GO:0004725; GO:0033003; GO:0007185 cytoplasm; integral to membrane; intermediate filament cytoskeleton; negative regulation of insulin receptor signaling pathway; nucleus; plasma membrane; protein homodimerization activity; protein tyrosine phosphatase activity; regulation of mast cell activation; transmembrane receptor protein tyrosine phosphatase signaling pathway IPR000387; IPR016130; IPR000242; IPR016336; Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) Ptpre Ptpe Mus musculus (Mouse) TR38264_c2_g3_i3 B2RU80 PTPRB_MOUSE 8.00E-77 GO:0001525; GO:0016021; GO:0035335; GO:0004725 angiogenesis; integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) Ptprb Mus musculus (Mouse) TR38266_c0_g2_i1 Q8R5L3 VPS39_MOUSE 0 GO:0006886; GO:0031902; GO:0005765; GO:0005083; GO:0016192 intracellular protein transport; late endosome membrane; lysosomal membrane; small GTPase regulator activity; vesicle-mediated transport IPR001180; IPR000547; IPR019452; IPR019453; Vam6/Vps39-like protein Vps39 Pldn Vam6 Mus musculus (Mouse) TR38267_c1_g1_i2 P35408 PE2R4_HUMAN 2.00E-46 GO:0070371; GO:0007254; GO:0042093; GO:0007188; GO:0060348; GO:0071260; GO:0016021; GO:0050710; GO:2000420; GO:0050728; GO:0033624; GO:0005886; GO:0050715; GO:0050729; GO:0004957; GO:0030278; GO:0051492; GO:0032496 ERK1 and ERK2 cascade; JNK cascade; T-helper cell differentiation; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; bone development; cellular response to mechanical stimulus; integral to membrane; negative regulation of cytokine secretion; negative regulation of eosinophil extravasation; negative regulation of inflammatory response; negative regulation of integrin activation; plasma membrane; positive regulation of cytokine secretion; positive regulation of inflammatory response; prostaglandin E receptor activity; regulation of ossification; regulation of stress fiber assembly; response to lipopolysaccharide IPR000276; IPR017452; IPR001758; IPR008365; IPR001244; Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 PTGER2 Homo sapiens (Human) TR38267_c1_g1_i4 P35408 PE2R4_HUMAN 3.00E-46 GO:0070371; GO:0007254; GO:0042093; GO:0007188; GO:0060348; GO:0071260; GO:0016021; GO:0050710; GO:2000420; GO:0050728; GO:0033624; GO:0005886; GO:0050715; GO:0050729; GO:0004957; GO:0030278; GO:0051492; GO:0032496 ERK1 and ERK2 cascade; JNK cascade; T-helper cell differentiation; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; bone development; cellular response to mechanical stimulus; integral to membrane; negative regulation of cytokine secretion; negative regulation of eosinophil extravasation; negative regulation of inflammatory response; negative regulation of integrin activation; plasma membrane; positive regulation of cytokine secretion; positive regulation of inflammatory response; prostaglandin E receptor activity; regulation of ossification; regulation of stress fiber assembly; response to lipopolysaccharide IPR000276; IPR017452; IPR001758; IPR008365; IPR001244; Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 PTGER2 Homo sapiens (Human) TR38268_c0_g1_i1 Q92620 PRP16_HUMAN 0 GO:0005524; GO:0008026; GO:0071013; GO:0031124; GO:0006406; GO:0000398; GO:0003676; GO:0005654; GO:0006369 O60231; Q92917; P98175 "ATP binding; ATP-dependent helicase activity; catalytic step 2 spliceosome; mRNA 3'-end processing; mRNA export from nucleus; mRNA splicing, via spliceosome; nucleic acid binding; nucleoplasm; termination of RNA polymerase II transcription" IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38) DHX38 DDX38 KIAA0224 PRP16 Homo sapiens (Human) TR38268_c0_g1_i2 Q8VHK9 DHX36_MOUSE 2.00E-52 GO:0005524; GO:0008026; GO:0003725; GO:0005634; GO:0043330; GO:0009615 ATP binding; ATP-dependent helicase activity; double-stranded RNA binding; nucleus; response to exogenous dsRNA; response to virus IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Probable ATP-dependent RNA helicase DHX36 (EC 3.6.4.13) (DEAH box protein 36) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE) Dhx36 Ddx36 Kiaa1488 Mlel1 Mus musculus (Mouse) TR38268_c0_g1_i4 Q9HDY4 YK16_SCHPO 3.00E-68 GO:0005524; GO:0004004; GO:0003723; GO:0030490; GO:0005730; GO:0032040 ATP binding; ATP-dependent RNA helicase activity; RNA binding; maturation of SSU-rRNA; nucleolus; small-subunit processome IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Putative ATP-dependent RNA helicase PB1A10.06c (EC 3.6.4.13) SPAPB1A10.06c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR3827_c0_g1_i1 P48556 PSMD8_HUMAN 2.00E-29 GO:0006977; GO:0000082; GO:0031145; GO:0002479; GO:0006915; GO:0005829; GO:0010467; GO:0016071; GO:0043066; GO:0051436; GO:0005654; GO:0051437; GO:0005838; GO:0000209; GO:0006521; GO:0044281; GO:0016032 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G1/S transition of mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic process; cytosol; gene expression; mRNA metabolic process; negative regulation of apoptotic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; proteasome regulatory particle; protein polyubiquitination; regulation of cellular amino acid metabolic process; small molecule metabolic process; viral process" IPR006746; 26S proteasome non-ATPase regulatory subunit 8 (26S proteasome regulatory subunit RPN12) (26S proteasome regulatory subunit S14) (p31) PSMD8 Homo sapiens (Human) TR38270_c0_g2_i1 Q29RI0 ADCK3_BOVIN 0 GO:0005524; GO:0005739; GO:0004674 ATP binding; mitochondrion; protein serine/threonine kinase activity IPR011009; IPR004147; "Chaperone activity of bc1 complex-like, mitochondrial (Chaperone-ABC1-like) (EC 2.7.11.-) (aarF domain-containing protein kinase 3)" ADCK3 CABC1 Bos taurus (Bovine) TR38270_c0_g2_i2 Q29RI0 ADCK3_BOVIN 0 GO:0005524; GO:0005739; GO:0004674 ATP binding; mitochondrion; protein serine/threonine kinase activity IPR011009; IPR004147; "Chaperone activity of bc1 complex-like, mitochondrial (Chaperone-ABC1-like) (EC 2.7.11.-) (aarF domain-containing protein kinase 3)" ADCK3 CABC1 Bos taurus (Bovine) TR38270_c0_g2_i3 Q6AY19 ADCK4_RAT 1.00E-178 GO:0016021; GO:0004674 integral to membrane; protein serine/threonine kinase activity IPR011009; IPR004147; Uncharacterized aarF domain-containing protein kinase 4 (EC 2.7.11.-) Adck4 Rattus norvegicus (Rat) TR38271_c0_g1_i1 Q93VG8 PPDEX_ARATH 1.00E-34 GO:0008233; GO:0006508 peptidase activity; proteolysis IPR008580; DeSI-like protein At4g17486 (EC 3.4.-.-) At4g17486 dl4780c FCAALL.234 Arabidopsis thaliana (Mouse-ear cress) TR38271_c0_g1_i2 Q5PQ09 DESI2_XENLA 2.00E-82 GO:0005737; GO:0008233; GO:0006508 cytoplasm; peptidase activity; proteolysis IPR008580; Desumoylating isopeptidase 2 (DeSI-2) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 1) (Protein FAM152A) desi2 fam152a pppde1 Xenopus laevis (African clawed frog) TR38272_c0_g1_i1 Q95KD7 K1407_MACFA 3.00E-23 IPR026174; Coiled-coil domain-containing protein KIAA1407 homolog QflA-14927 QtsA-14717 QtsA-16413 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38272_c5_g8_i1 Q5PQP2 RCAS1_RAT 1.00E-12 GO:0000139; GO:0006915; GO:0016021; GO:0030141 Golgi membrane; apoptotic process; integral to membrane; secretory granule IPR017025; Receptor-binding cancer antigen expressed on SiSo cells (Estrogen receptor-binding fragment-associated gene 9 protein) Ebag9 Rattus norvegicus (Rat) TR38273_c0_g1_i2 Q29RV1 PDIA4_BOVIN 1.00E-43 GO:0045454; GO:0005788; GO:0006662; GO:0042470; GO:0003756; GO:0015035; GO:0006457 cell redox homeostasis; endoplasmic reticulum lumen; glycerol ether metabolic process; melanosome; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; protein folding IPR005788; IPR005792; IPR017068; IPR005746; IPR012336; IPR017937; IPR013766; Protein disulfide-isomerase A4 (EC 5.3.4.1) PDIA4 Bos taurus (Bovine) TR38273_c0_g4_i1 P38657 PDIA3_BOVIN 9.00E-47 GO:0045454; GO:0005783; GO:0005788; GO:0006662; GO:0042470; GO:0043065; GO:0003756; GO:0015035; GO:0006457 cell redox homeostasis; endoplasmic reticulum; endoplasmic reticulum lumen; glycerol ether metabolic process; melanosome; positive regulation of apoptotic process; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; protein folding IPR005788; IPR005792; IPR005746; IPR012336; IPR017937; IPR013766; Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) PDIA3 GRP58 Bos taurus (Bovine) TR38273_c0_g4_i4 Q50KB1 SEP2_EMIHU 1.00E-13 GO:0045454; GO:0005783; GO:0005788; GO:0003756 cell redox homeostasis; endoplasmic reticulum; endoplasmic reticulum lumen; protein disulfide isomerase activity IPR005788; IPR012336; IPR013766; Protein disulfide-isomerase-like protein EhSep2 2-Sep Emiliania huxleyi (Pontosphaera huxleyi) TR38273_c0_g5_i1 P38661 PDIA6_MEDSA 2.00E-50 GO:0045454; GO:0005788; GO:0006662; GO:0003756; GO:0015035; GO:0006457 cell redox homeostasis; endoplasmic reticulum lumen; glycerol ether metabolic process; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; protein folding IPR005788; IPR011679; IPR005746; IPR012336; IPR017937; IPR013766; Probable protein disulfide-isomerase A6 (EC 5.3.4.1) (P5) Medicago sativa (Alfalfa) TR38273_c0_g5_i2 P08003 PDIA4_MOUSE 1.00E-88 GO:0045454; GO:0009986; GO:0005783; GO:0005788; GO:0006662; GO:0042470; GO:0003756; GO:0015035 cell redox homeostasis; cell surface; endoplasmic reticulum; endoplasmic reticulum lumen; glycerol ether metabolic process; melanosome; protein disulfide isomerase activity; protein disulfide oxidoreductase activity IPR005788; IPR005792; IPR017068; IPR005746; IPR012336; IPR017937; IPR013766; Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) Pdia4 Cai Erp72 Mus musculus (Mouse) TR38273_c0_g5_i3 Q8NBS9 TXND5_HUMAN 2.00E-40 GO:0045454; GO:0005783; GO:0005788; GO:0006662; GO:0016853; GO:0043202; GO:0043066; GO:0006892; GO:0015035 Q13162 cell redox homeostasis; endoplasmic reticulum; endoplasmic reticulum lumen; glycerol ether metabolic process; isomerase activity; lysosomal lumen; negative regulation of apoptotic process; post-Golgi vesicle-mediated transport; protein disulfide oxidoreductase activity IPR005788; IPR005746; IPR012336; IPR017937; IPR013766; Thioredoxin domain-containing protein 5 (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46) TXNDC5 TLP46 UNQ364/PRO700 Homo sapiens (Human) TR38274_c1_g1_i2 Q5RBG4 KAT5_PONAB 3.00E-97 GO:0006978; GO:0032777; GO:0016573; GO:0004402; GO:0046872; GO:0005730; GO:0048471; GO:0045893; GO:0040008; GO:0003713; GO:0006351 "DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; Piccolo NuA4 histone acetyltransferase complex; histone acetylation; histone acetyltransferase activity; metal ion binding; nucleolus; perinuclear region of cytoplasm; positive regulation of transcription, DNA-dependent; regulation of growth; transcription coactivator activity; transcription, DNA-dependent" IPR016181; IPR000953; IPR016197; IPR002717; IPR025995; Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (Lysine acetyltransferase 5) KAT5 HTATIP TIP60 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38274_c1_g2_i2 Q5RBG4 KAT5_PONAB 5.00E-98 GO:0006978; GO:0032777; GO:0016573; GO:0004402; GO:0046872; GO:0005730; GO:0048471; GO:0045893; GO:0040008; GO:0003713; GO:0006351 "DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; Piccolo NuA4 histone acetyltransferase complex; histone acetylation; histone acetyltransferase activity; metal ion binding; nucleolus; perinuclear region of cytoplasm; positive regulation of transcription, DNA-dependent; regulation of growth; transcription coactivator activity; transcription, DNA-dependent" IPR016181; IPR000953; IPR016197; IPR002717; IPR025995; Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (Lysine acetyltransferase 5) KAT5 HTATIP TIP60 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38275_c1_g1_i1 Q04202 TCB2_CAEBR 4.00E-14 GO:0003677; GO:0015074; GO:0005634; GO:0004803; GO:0006313 "DNA binding; DNA integration; nucleus; transposase activity; transposition, DNA-mediated" IPR002492; Transposable element Tcb2 transposase Caenorhabditis briggsae TR38275_c3_g1_i3 P86854 PLCL_MYTGA 4.00E-06 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR38276_c3_g1_i1 B3EWP6 PA2_LACMR 2.00E-07 GO:0005509; GO:0019835; GO:0005576; GO:0044179; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; cytolysis; extracellular region; hemolysis in other organism; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Phospholipase A2 (Lmr-PLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (Fragment) Lachesis muta rhombeata (Bushmaster) TR38276_c3_g2_i10 Q9PUH7 PA2A7_AUSSU 2.00E-14 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Acidic phospholipase A2 S15-109 (svPLA2) (EC 3.1.1.4) (ASPLA7) (Phosphatidylcholine 2-acylhydrolase) Austrelaps superbus (Lowland copperhead snake) (Hoplocephalus superbus) TR38276_c3_g2_i15 P59067 PA2SA_AUSSU 5.00E-09 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Phospholipase A2 superbin a (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (Fragment) Austrelaps superbus (Lowland copperhead snake) (Hoplocephalus superbus) TR38276_c3_g2_i17 Q9WVF6 PA2GD_MOUSE 9.00E-15 GO:0005509; GO:0005737; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; cytoplasm; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; "Group IID secretory phospholipase A2 (GIID sPLA2) (sPLA2-IID) (EC 3.1.1.4) (PLA2IID) (Phosphatidylcholine 2-acylhydrolase 2D) (Secretory-type PLA, stroma-associated homolog)" Pla2g2d Pla2a2 Splash Mus musculus (Mouse) TR38276_c3_g2_i18 P47711 PA2GA_CAVPO 5.00E-14 GO:0005509; GO:0016042; GO:0016020; GO:0004623; GO:0006644 calcium ion binding; lipid catabolic process; membrane; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; "Phospholipase A2, membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 2A)" PLA2G2A Cavia porcellus (Guinea pig) TR38276_c3_g2_i20 Q9UNK4 PA2GD_HUMAN 7.00E-15 GO:0005509; GO:0005576; GO:0006954; GO:0016042; GO:0006654; GO:0036151; GO:0036152; GO:0036148; GO:0036149; GO:0036150; GO:0004623 calcium ion binding; extracellular region; inflammatory response; lipid catabolic process; phosphatidic acid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; phosphatidylinositol acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; phospholipase A2 activity IPR001211; IPR013090; IPR016090; "Group IID secretory phospholipase A2 (GIID sPLA2) (sPLA2-IID) (EC 3.1.1.4) (PLA2IID) (Phosphatidylcholine 2-acylhydrolase 2D) (Secretory-type PLA, stroma-associated homolog)" PLA2G2D SPLASH Homo sapiens (Human) TR38276_c3_g2_i5 P00606 PA2A_BUNMU 2.00E-16 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Acidic phospholipase A2 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) Bungarus multicinctus (Many-banded krait) TR38276_c3_g2_i8 P14423 PA2GA_RAT 5.00E-15 GO:0005509; GO:0047498; GO:0005783; GO:0005615; GO:0016042; GO:0016020; GO:0046473; GO:0005543; GO:0006644; GO:0030141 calcium ion binding; calcium-dependent phospholipase A2 activity; endoplasmic reticulum; extracellular space; lipid catabolic process; membrane; phosphatidic acid metabolic process; phospholipid binding; phospholipid metabolic process; secretory granule IPR001211; IPR013090; IPR016090; "Phospholipase A2, membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 2A)" Pla2g2a Rattus norvegicus (Rat) TR38276_c3_g4_i1 C1JAR9 PA2_SCOVI 1.00E-07 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Phospholipase A2 Scol/Pla (PLA2) (EC 3.1.1.4) Scolopendra viridis (Giant centipede) TR38276_c3_g5_i1 P60044 PA2A2_NAJSG 7.00E-13 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Acidic phospholipase A2 2 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (Fragment) Naja sagittifera (Andaman cobra) TR38278_c9_g1_i1 Q9H5I5 PIEZ2_HUMAN 2.00E-35 GO:0005261; GO:0006812; GO:0016021; GO:0008381; GO:0042391 cation channel activity; cation transport; integral to membrane; mechanically-gated ion channel activity; regulation of membrane potential IPR027272; Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) PIEZO2 C18orf30 C18orf58 FAM38B Homo sapiens (Human) TR38279_c0_g1_i1 P23004 QCR2_BOVIN 6.00E-89 GO:0046872; GO:0004222; GO:0005743; GO:0055114; GO:0006508; GO:0070469 metal ion binding; metalloendopeptidase activity; mitochondrial inner membrane; oxidation-reduction process; proteolysis; respiratory chain IPR011249; IPR011237; IPR011765; IPR001431; IPR007863; "Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2)" UQCRC2 Bos taurus (Bovine) TR38281_c1_g1_i1 Q60769 TNAP3_MOUSE 2.00E-45 GO:0001922; GO:0003677; GO:0006915; GO:0070301; GO:0071222; GO:0005813; GO:0005737; GO:0006954; GO:0019900; GO:0005764; GO:0002315; GO:0050869; GO:2000349; GO:0043124; GO:0032088; GO:0010507; GO:0060548; GO:0002677; GO:0045736; GO:2000352; GO:1902042; GO:0002632; GO:0034115; GO:0045824; GO:0032691; GO:0032703; GO:0032715; GO:0070429; GO:0070433; GO:0031397; GO:0048662; GO:0034140; GO:0034148; GO:0032720; GO:0005634; GO:2000347; GO:0045732; GO:0035871; GO:0071108; GO:0070936; GO:0070536; GO:0006508; GO:0002634; GO:0002637; GO:0032495; GO:0009611; GO:0072573; GO:0004221; GO:0004842; GO:0004843; GO:0008270 Q9WUU8; P39429 B-1 B cell homeostasis; DNA binding; apoptotic process; cellular response to hydrogen peroxide; cellular response to lipopolysaccharide; centrosome; cytoplasm; inflammatory response; kinase binding; lysosome; marginal zone B cell differentiation; negative regulation of B cell activation; negative regulation of CD40 signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of autophagy; negative regulation of cell death; negative regulation of chronic inflammatory response; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of endothelial cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of granuloma formation; negative regulation of heterotypic cell-cell adhesion; negative regulation of innate immune response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-2 production; negative regulation of interleukin-6 production; negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; negative regulation of protein ubiquitination; negative regulation of smooth muscle cell proliferation; negative regulation of toll-like receptor 3 signaling pathway; negative regulation of toll-like receptor 5 signaling pathway; negative regulation of tumor necrosis factor production; nucleus; positive regulation of hepatocyte proliferation; positive regulation of protein catabolic process; protein K11-linked deubiquitination; protein K48-linked deubiquitination; protein K48-linked ubiquitination; protein K63-linked deubiquitination; proteolysis; regulation of germinal center formation; regulation of immunoglobulin production; response to muramyl dipeptide; response to wounding; tolerance induction to lipopolysaccharide; ubiquitin thiolesterase activity; ubiquitin-protein ligase activity; ubiquitin-specific protease activity; zinc ion binding IPR003323; IPR002653; Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 3.4.19.12) (EC 6.3.2.-) (Putative DNA-binding protein A20) (Zinc finger protein A20) Tnfaip3 Tnfip3 Mus musculus (Mouse) TR38281_c1_g1_i2 Q8R554 OTU7A_MOUSE 5.00E-28 GO:0003677; GO:0005737; GO:0005634; GO:0035871; GO:0006508; GO:0004843; GO:0008270 DNA binding; cytoplasm; nucleus; protein K11-linked deubiquitination; proteolysis; ubiquitin-specific protease activity; zinc ion binding IPR003323; IPR002653; OTU domain-containing protein 7A (EC 3.4.19.12) (Zinc finger protein Cezanne 2) Otud7a Cezanne2 Otud7 Mus musculus (Mouse) TR38281_c1_g1_i3 Q60769 TNAP3_MOUSE 2.00E-45 GO:0001922; GO:0003677; GO:0006915; GO:0070301; GO:0071222; GO:0005813; GO:0005737; GO:0006954; GO:0019900; GO:0005764; GO:0002315; GO:0050869; GO:2000349; GO:0043124; GO:0032088; GO:0010507; GO:0060548; GO:0002677; GO:0045736; GO:2000352; GO:1902042; GO:0002632; GO:0034115; GO:0045824; GO:0032691; GO:0032703; GO:0032715; GO:0070429; GO:0070433; GO:0031397; GO:0048662; GO:0034140; GO:0034148; GO:0032720; GO:0005634; GO:2000347; GO:0045732; GO:0035871; GO:0071108; GO:0070936; GO:0070536; GO:0006508; GO:0002634; GO:0002637; GO:0032495; GO:0009611; GO:0072573; GO:0004221; GO:0004842; GO:0004843; GO:0008270 Q9WUU8; P39429 B-1 B cell homeostasis; DNA binding; apoptotic process; cellular response to hydrogen peroxide; cellular response to lipopolysaccharide; centrosome; cytoplasm; inflammatory response; kinase binding; lysosome; marginal zone B cell differentiation; negative regulation of B cell activation; negative regulation of CD40 signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of autophagy; negative regulation of cell death; negative regulation of chronic inflammatory response; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of endothelial cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of granuloma formation; negative regulation of heterotypic cell-cell adhesion; negative regulation of innate immune response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-2 production; negative regulation of interleukin-6 production; negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; negative regulation of protein ubiquitination; negative regulation of smooth muscle cell proliferation; negative regulation of toll-like receptor 3 signaling pathway; negative regulation of toll-like receptor 5 signaling pathway; negative regulation of tumor necrosis factor production; nucleus; positive regulation of hepatocyte proliferation; positive regulation of protein catabolic process; protein K11-linked deubiquitination; protein K48-linked deubiquitination; protein K48-linked ubiquitination; protein K63-linked deubiquitination; proteolysis; regulation of germinal center formation; regulation of immunoglobulin production; response to muramyl dipeptide; response to wounding; tolerance induction to lipopolysaccharide; ubiquitin thiolesterase activity; ubiquitin-protein ligase activity; ubiquitin-specific protease activity; zinc ion binding IPR003323; IPR002653; Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 3.4.19.12) (EC 6.3.2.-) (Putative DNA-binding protein A20) (Zinc finger protein A20) Tnfaip3 Tnfip3 Mus musculus (Mouse) TR38281_c1_g1_i4 P21580 TNAP3_HUMAN 5.00E-45 GO:0001922; GO:0003677; GO:0006915; GO:0070301; GO:0005813; GO:0005829; GO:0006954; GO:0045087; GO:0005764; GO:0050869; GO:2000349; GO:0043124; GO:0032088; GO:0045779; GO:0002677; GO:0045736; GO:2000352; GO:1902042; GO:0050728; GO:0045824; GO:0032691; GO:0032703; GO:0032715; GO:0070429; GO:0070433; GO:0090291; GO:0031397; GO:0048662; GO:0034136; GO:0034140; GO:0034148; GO:0032720; GO:0032480; GO:0070423; GO:0005634; GO:2000347; GO:0045732; GO:0035871; GO:0071108; GO:0070936; GO:0070536; GO:0051259; GO:0043621; GO:0006508; GO:0050691; GO:0002634; GO:0061043; GO:0032495; GO:0072573; GO:0004221; GO:0004842; GO:0004843; GO:0008270 Q9Y6K9; Q9Y3C5; P68510 B-1 B cell homeostasis; DNA binding; apoptotic process; cellular response to hydrogen peroxide; centrosome; cytosol; inflammatory response; innate immune response; lysosome; negative regulation of B cell activation; negative regulation of CD40 signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of bone resorption; negative regulation of chronic inflammatory response; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of endothelial cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of inflammatory response; negative regulation of innate immune response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-2 production; negative regulation of interleukin-6 production; negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; negative regulation of osteoclast proliferation; negative regulation of protein ubiquitination; negative regulation of smooth muscle cell proliferation; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of toll-like receptor 3 signaling pathway; negative regulation of toll-like receptor 5 signaling pathway; negative regulation of tumor necrosis factor production; negative regulation of type I interferon production; nucleotide-binding oligomerization domain containing signaling pathway; nucleus; positive regulation of hepatocyte proliferation; positive regulation of protein catabolic process; protein K11-linked deubiquitination; protein K48-linked deubiquitination; protein K48-linked ubiquitination; protein K63-linked deubiquitination; protein oligomerization; protein self-association; proteolysis; regulation of defense response to virus by host; regulation of germinal center formation; regulation of vascular wound healing; response to muramyl dipeptide; tolerance induction to lipopolysaccharide; ubiquitin thiolesterase activity; ubiquitin-protein ligase activity; ubiquitin-specific protease activity; zinc ion binding IPR003323; IPR002653; Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 3.4.19.12) (EC 6.3.2.-) (OTU domain-containing protein 7C) (Putative DNA-binding protein A20) (Zinc finger protein A20) [Cleaved into: A20p50; A20p37] TNFAIP3 OTUD7C Homo sapiens (Human) TR38282_c1_g1_i1 Q8HZY8 CC148_MACFA 2.00E-14 Coiled-coil domain-containing protein 148 CCDC148 QflA-10778 QtsA-12190 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38282_c3_g1_i1 Q505D1 ANR28_MOUSE 3.00E-07 GO:0005654 nucleoplasm IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) Ankrd28 Mus musculus (Mouse) TR38282_c5_g1_i1 Q8HZY8 CC148_MACFA 3.00E-64 Coiled-coil domain-containing protein 148 CCDC148 QflA-10778 QtsA-12190 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38283_c1_g1_i1 Q9VAI1 CIA30_DROME 5.00E-71 GO:0006120; GO:0005747; GO:0051082 "mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I; unfolded protein binding" IPR008979; IPR013857; "Probable complex I intermediate-associated protein 30, mitochondrial" CG7598 Drosophila melanogaster (Fruit fly) TR38283_c1_g1_i7 Q9VAI1 CIA30_DROME 5.00E-49 GO:0006120; GO:0005747; GO:0051082 "mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I; unfolded protein binding" IPR008979; IPR013857; "Probable complex I intermediate-associated protein 30, mitochondrial" CG7598 Drosophila melanogaster (Fruit fly) TR38285_c0_g1_i1 Q8Q0U0 Y045_METMA 1.00E-13 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR38285_c0_g1_i3 G5E8K5 ANK3_MOUSE 6.00E-12 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR38285_c0_g1_i4 Q7XUW4 KOR2_ORYSJ 3.00E-10 GO:0016021; GO:0005249 integral to membrane; voltage-gated potassium channel activity IPR002110; IPR020683; IPR018490; IPR000595; IPR005821; IPR003938; IPR014710; Potassium channel KOR2 (K(+) outward-rectifying channel 2) Os04g0445000 LOC_Os04g36740 OSJNBa0027P08.8 Oryza sativa subsp. japonica (Rice) TR38285_c0_g1_i5 Q9M8S6 SKOR_ARATH 2.00E-13 GO:0016021; GO:0015271 integral to membrane; outward rectifier potassium channel activity IPR002110; IPR020683; IPR018490; IPR000595; IPR005821; IPR021789; IPR003938; IPR014710; Potassium channel SKOR (Stelar K(+) outward rectifying channel) SKOR At3g02850 F13E7.21 Arabidopsis thaliana (Mouse-ear cress) TR38287_c1_g3_i11 A6H6E2 MMRN2_MOUSE 3.00E-07 GO:0001525; GO:0005604; GO:0005615; GO:0090051; GO:0030948 angiogenesis; basement membrane; extracellular space; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of vascular endothelial growth factor receptor signaling pathway IPR001073; IPR011489; IPR008983; Multimerin-2 Mmrn2 Mus musculus (Mouse) TR38287_c1_g3_i12 P83425 HIP_MYTED 4.00E-07 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR38287_c1_g3_i17 Q9BXX0 EMIL2_HUMAN 8.00E-06 GO:0007155; GO:0005581; GO:0030023; GO:0005576 cell adhesion; collagen; extracellular matrix constituent conferring elasticity; extracellular region IPR001073; IPR011489; IPR008983; EMILIN-2 (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10) EMILIN2 Homo sapiens (Human) TR38287_c1_g3_i2 A6H6E2 MMRN2_MOUSE 4.00E-07 GO:0001525; GO:0005604; GO:0005615; GO:0090051; GO:0030948 angiogenesis; basement membrane; extracellular space; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of vascular endothelial growth factor receptor signaling pathway IPR001073; IPR011489; IPR008983; Multimerin-2 Mmrn2 Mus musculus (Mouse) TR38288_c0_g1_i2 Q86Z23 C1QL4_HUMAN 1.00E-06 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) C1QL4 CTRP11 Homo sapiens (Human) TR38289_c3_g1_i1 Q5R684 UBQL1_PONAB 9.00E-128 GO:0005737; GO:0005634; GO:0000502 cytoplasm; nucleus; proteasome complex IPR006636; IPR009060; IPR015940; IPR015496; IPR000626; Ubiquilin-1 UBQLN1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38289_c3_g1_i2 Q8R317 UBQL1_MOUSE 2.00E-99 GO:0071456; GO:0005783; GO:0097194; GO:0019215; GO:0019900; GO:0005634; GO:0048471; GO:0000502; GO:0005102; GO:0031396; GO:0034976 cellular response to hypoxia; endoplasmic reticulum; execution phase of apoptosis; intermediate filament binding; kinase binding; nucleus; perinuclear region of cytoplasm; proteasome complex; receptor binding; regulation of protein ubiquitination; response to endoplasmic reticulum stress IPR006636; IPR009060; IPR015940; IPR000449; IPR015496; IPR000626; Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) Ubqln1 Plic1 Mus musculus (Mouse) TR38289_c3_g1_i3 Q9UHD9 UBQL2_HUMAN 1.00E-60 GO:0008219; GO:0005737; GO:0005634; GO:0005886 Q16186; P55036; P54725; O48726 cell death; cytoplasm; nucleus; plasma membrane IPR016024; IPR006636; IPR009060; IPR015940; IPR000449; IPR015496; IPR000626; Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2) UBQLN2 N4BP4 PLIC2 HRIHFB2157 Homo sapiens (Human) TR3829_c1_g1_i1 A8I1Q0 CALM_HETTR 3.00E-13 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Heterocapsa triquetra (Dinoflagellate) (Glenodinium triquetrum) TR38291_c3_g2_i10 P0C7B7 ELIC_ERWCH 2.00E-14 GO:0005230; GO:0016021; GO:0005886 extracellular ligand-gated ion channel activity; integral to membrane; plasma membrane IPR006202; IPR006201; IPR006029; Cys-loop ligand-gated ion channel (ELIC) Erwinia chrysanthemi TR38291_c3_g2_i2 P0C7B7 ELIC_ERWCH 2.00E-14 GO:0005230; GO:0016021; GO:0005886 extracellular ligand-gated ion channel activity; integral to membrane; plasma membrane IPR006202; IPR006201; IPR006029; Cys-loop ligand-gated ion channel (ELIC) Erwinia chrysanthemi TR38291_c3_g2_i5 O18276 GBRB_CAEEL 2.00E-09 GO:0004890; GO:0030054; GO:0005254; GO:0034707; GO:0005230; GO:0045211; GO:0045202; GO:0007268 GABA-A receptor activity; cell junction; chloride channel activity; chloride channel complex; extracellular ligand-gated ion channel activity; postsynaptic membrane; synapse; synaptic transmission IPR006028; IPR002289; IPR006202; IPR006201; IPR006029; IPR018000; Gamma-aminobutyric acid receptor subunit beta (GABA(A) receptor subunit beta) gab-1 ZC482.1 Caenorhabditis elegans TR38291_c3_g2_i6 P54244 ACH3_CAEEL 9.00E-06 GO:0030054; GO:0005230; GO:0016021; GO:0045211; GO:0043067 cell junction; extracellular ligand-gated ion channel activity; integral to membrane; postsynaptic membrane; regulation of programmed cell death IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; Acetylcholine receptor subunit alpha-type deg-3 deg-3 K03B8.9 Caenorhabditis elegans TR38291_c3_g2_i9 O18276 GBRB_CAEEL 2.00E-09 GO:0004890; GO:0030054; GO:0005254; GO:0034707; GO:0005230; GO:0045211; GO:0045202; GO:0007268 GABA-A receptor activity; cell junction; chloride channel activity; chloride channel complex; extracellular ligand-gated ion channel activity; postsynaptic membrane; synapse; synaptic transmission IPR006028; IPR002289; IPR006202; IPR006201; IPR006029; IPR018000; Gamma-aminobutyric acid receptor subunit beta (GABA(A) receptor subunit beta) gab-1 ZC482.1 Caenorhabditis elegans TR38292_c6_g2_i1 Q3T0T8 RGS5_BOVIN 4.00E-28 GO:0005096; GO:0005737; GO:0005886; GO:0038032 GTPase activator activity; cytoplasm; plasma membrane; termination of G-protein coupled receptor signaling pathway IPR024066; IPR016137; IPR000342; Regulator of G-protein signaling 5 (RGS5) RGS5 Bos taurus (Bovine) TR38292_c6_g2_i2 O45523 RGS10_CAEEL 9.00E-07 GO:0005096; GO:0005737; GO:0009792; GO:0005886; GO:0000003; GO:0038032 GTPase activator activity; cytoplasm; embryo development ending in birth or egg hatching; plasma membrane; reproduction; termination of G-protein coupled receptor signaling pathway IPR024066; IPR016137; IPR000342; Regulator of G-protein signaling rgs-10 rgs-10 F45B8.2 Caenorhabditis elegans TR38293_c3_g1_i1 Q24306 IAP1_DROME 7.00E-20 GO:0019788; GO:0016055; GO:0048800; GO:0007298; GO:0008407; GO:0004869; GO:0005737; GO:0008354; GO:0097340; GO:1990001; GO:0043066; GO:0046673; GO:0005634; GO:0090263; GO:0031398; GO:0042787; GO:0045035; GO:0007289; GO:0004842; GO:0008270 P25843; Q86PE7; Q9XYF4; Q24475; Q24106 NEDD8 ligase activity; Wnt receptor signaling pathway; antennal morphogenesis; border follicle cell migration; chaeta morphogenesis; cysteine-type endopeptidase inhibitor activity; cytoplasm; germ cell migration; inhibition of cysteine-type endopeptidase activity; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of compound eye retinal cell programmed cell death; nucleus; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; sensory organ precursor cell division; spermatid nucleus differentiation; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; Apoptosis 1 inhibitor (EC 6.3.2.-) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (dIAP1) (Protein thread) th Iap1 CG12284 Drosophila melanogaster (Fruit fly) TR38293_c3_g1_i2 Q24306 IAP1_DROME 3.00E-20 GO:0019788; GO:0016055; GO:0048800; GO:0007298; GO:0008407; GO:0004869; GO:0005737; GO:0008354; GO:0097340; GO:1990001; GO:0043066; GO:0046673; GO:0005634; GO:0090263; GO:0031398; GO:0042787; GO:0045035; GO:0007289; GO:0004842; GO:0008270 P25843; Q86PE7; Q9XYF4; Q24475; Q24106 NEDD8 ligase activity; Wnt receptor signaling pathway; antennal morphogenesis; border follicle cell migration; chaeta morphogenesis; cysteine-type endopeptidase inhibitor activity; cytoplasm; germ cell migration; inhibition of cysteine-type endopeptidase activity; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of compound eye retinal cell programmed cell death; nucleus; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; sensory organ precursor cell division; spermatid nucleus differentiation; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; Apoptosis 1 inhibitor (EC 6.3.2.-) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (dIAP1) (Protein thread) th Iap1 CG12284 Drosophila melanogaster (Fruit fly) TR38293_c5_g2_i3 A2AWP0 BIRC7_MOUSE 4.00E-16 GO:0005794; GO:0006915; GO:0004869; GO:0043066; GO:0005634; GO:0042127; GO:0070247; GO:0004842; GO:0008270 Golgi apparatus; apoptotic process; cysteine-type endopeptidase inhibitor activity; negative regulation of apoptotic process; nucleus; regulation of cell proliferation; regulation of natural killer cell apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; IPR017907; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (Livin) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30 kDa subunit (Truncated livin) (p30-Livin) (tLivin)] Birc7 Livin Mus musculus (Mouse) TR38293_c5_g2_i5 Q9QWK5 BIR1A_MOUSE 8.00E-10 GO:0005524; GO:0016323; GO:0071391; GO:0043027; GO:0005737; GO:0046872; GO:0043066; GO:0017111 ATP binding; basolateral plasma membrane; cellular response to estrogen stimulus; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; metal ion binding; negative regulation of apoptotic process; nucleoside-triphosphatase activity IPR003593; IPR001370; IPR007111; IPR027417; Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1) Naip1 Birc1a Naip Mus musculus (Mouse) TR38293_c5_g2_i7 Q9QUK4 BIR1B_MOUSE 6.00E-11 GO:0005524; GO:0072557; GO:0006915; GO:0071391; GO:0042742; GO:0016045; GO:0006954; GO:0045087; GO:0046872; GO:0070269 ATP binding; IPAF inflammasome complex; apoptotic process; cellular response to estrogen stimulus; defense response to bacterium; detection of bacterium; inflammatory response; innate immune response; metal ion binding; pyroptosis IPR001370; IPR007111; IPR027417; Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2) Naip2 Birc1b Naip-rs6 Mus musculus (Mouse) TR38293_c5_g2_i9 Q8JHV9 BIR7A_XENLA 2.00E-38 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR38295_c0_g1_i1 Q7T3B0 EIF3M_DANRE 8.00E-96 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0006446; GO:0003743 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; regulation of translational initiation; translation initiation factor activity IPR016024; IPR027528; IPR000717; IPR011991; Eukaryotic translation initiation factor 3 subunit M (eIF3m) eif3m si:ch211-4l14.1 zgc:63996 Danio rerio (Zebrafish) (Brachydanio rerio) TR38295_c0_g2_i1 A1DC62 EIF3M_NEOFI 8.00E-07 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0006446; GO:0003743 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; regulation of translational initiation; translation initiation factor activity IPR027528; IPR000717; Eukaryotic translation initiation factor 3 subunit M (eIF3m) NFIA_024940 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) TR38296_c0_g1_i1 P07374 UREA_CANEN 1.00E-06 GO:0016151; GO:0043419; GO:0009039 nickel cation binding; urea catabolic process; urease activity IPR006680; IPR011059; IPR008221; IPR011612; IPR005848; IPR017951; IPR017950; IPR002019; IPR002026; Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. Urease (EC 3.5.1.5) (Urea amidohydrolase) Canavalia ensiformis (Jack bean) (Dolichos ensiformis) TR38296_c0_g1_i3 Q6P926 SPA24_MOUSE 1.00E-18 GO:0003677; GO:0030154; GO:0005737; GO:0007275; GO:0005730; GO:0005654; GO:0005634; GO:0042803; GO:0006355; GO:0007283; GO:0006351 "DNA binding; cell differentiation; cytoplasm; multicellular organismal development; nucleolus; nucleoplasm; nucleus; protein homodimerization activity; regulation of transcription, DNA-dependent; spermatogenesis; transcription, DNA-dependent" Spermatogenesis-associated protein 24 (TATA-binding protein-like factor-interacting protein) (TLF-interacting protein) (TRF2-interacting protein in testis) (Testis protein T6441 homolog) Spata24 Tipt Tipt2 Mus musculus (Mouse) TR38296_c0_g1_i4 P07374 UREA_CANEN 1.00E-06 GO:0016151; GO:0043419; GO:0009039 nickel cation binding; urea catabolic process; urease activity IPR006680; IPR011059; IPR008221; IPR011612; IPR005848; IPR017951; IPR017950; IPR002019; IPR002026; Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. Urease (EC 3.5.1.5) (Urea amidohydrolase) Canavalia ensiformis (Jack bean) (Dolichos ensiformis) TR38296_c0_g1_i6 Q6P926 SPA24_MOUSE 9.00E-19 GO:0003677; GO:0030154; GO:0005737; GO:0007275; GO:0005730; GO:0005654; GO:0005634; GO:0042803; GO:0006355; GO:0007283; GO:0006351 "DNA binding; cell differentiation; cytoplasm; multicellular organismal development; nucleolus; nucleoplasm; nucleus; protein homodimerization activity; regulation of transcription, DNA-dependent; spermatogenesis; transcription, DNA-dependent" Spermatogenesis-associated protein 24 (TATA-binding protein-like factor-interacting protein) (TLF-interacting protein) (TRF2-interacting protein in testis) (Testis protein T6441 homolog) Spata24 Tipt Tipt2 Mus musculus (Mouse) TR38296_c0_g2_i2 Q96WV0 UREG_SCHPO 6.00E-94 GO:0005524; GO:0005525; GO:0003924; GO:0005829; GO:0016530; GO:0016151; GO:0005634; GO:0019627 ATP binding; GTP binding; GTPase activity; cytosol; metallochaperone activity; nickel cation binding; nucleus; urea metabolic process IPR003495; IPR012202; IPR027417; IPR004400; Uncharacterized urease accessory protein ureG-like SPCPB16A4.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38296_c0_g2_i5 A7HHN3 UREG_ANADF 6.00E-91 GO:0005524; GO:0005525; GO:0003924; GO:0005737; GO:0016530; GO:0016151 ATP binding; GTP binding; GTPase activity; cytoplasm; metallochaperone activity; nickel cation binding IPR003495; IPR012202; IPR027417; IPR004400; Urease accessory protein UreG ureG Anae109_4051 Anaeromyxobacter sp. (strain Fw109-5) TR38297_c3_g1_i1 Q9JJ19 NHRF1_RAT 2.00E-55 GO:0016055; GO:0030036; GO:0007191; GO:0016324; GO:0032782; GO:0031526; GO:0019933; GO:0030643; GO:0034613; GO:0005813; GO:0017081; GO:0005737; GO:0012505; GO:0030175; GO:0034635; GO:0045121; GO:0030033; GO:0031528; GO:0070373; GO:0030336; GO:2000146; GO:0008285; GO:0014067; GO:0010642; GO:0051898; GO:0010766; GO:0032416; GO:0060158; GO:2001244; GO:0032947; GO:0044062; GO:0045859; GO:0097291; GO:0003096; GO:0001726; GO:0097225 O35240 Wnt receptor signaling pathway; actin cytoskeleton organization; adenylate cyclase-activating dopamine receptor signaling pathway; apical plasma membrane; bile acid secretion; brush border membrane; cAMP-mediated signaling; cellular phosphate ion homeostasis; cellular protein localization; centrosome; chloride channel regulator activity; cytoplasm; endomembrane system; filopodium; glutathione transport; membrane raft; microvillus assembly; microvillus membrane; negative regulation of ERK1 and ERK2 cascade; negative regulation of cell migration; negative regulation of cell motility; negative regulation of cell proliferation; negative regulation of phosphatidylinositol 3-kinase cascade; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein kinase B signaling cascade; negative regulation of sodium ion transport; negative regulation of sodium:hydrogen antiporter activity; phospholipase C-activating dopamine receptor signaling pathway; positive regulation of intrinsic apoptotic signaling pathway; protein complex scaffold; regulation of excretion; regulation of protein kinase activity; renal phosphate ion absorption; renal sodium ion transport; ruffle; sperm midpiece IPR015098; IPR017300; IPR001478; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) Slc9a3r1 Nherf Nherf1 Rattus norvegicus (Rat) TR38297_c3_g1_i4 Q9JJ19 NHRF1_RAT 3.00E-54 GO:0016055; GO:0030036; GO:0007191; GO:0016324; GO:0032782; GO:0031526; GO:0019933; GO:0030643; GO:0034613; GO:0005813; GO:0017081; GO:0005737; GO:0012505; GO:0030175; GO:0034635; GO:0045121; GO:0030033; GO:0031528; GO:0070373; GO:0030336; GO:2000146; GO:0008285; GO:0014067; GO:0010642; GO:0051898; GO:0010766; GO:0032416; GO:0060158; GO:2001244; GO:0032947; GO:0044062; GO:0045859; GO:0097291; GO:0003096; GO:0001726; GO:0097225 O35240 Wnt receptor signaling pathway; actin cytoskeleton organization; adenylate cyclase-activating dopamine receptor signaling pathway; apical plasma membrane; bile acid secretion; brush border membrane; cAMP-mediated signaling; cellular phosphate ion homeostasis; cellular protein localization; centrosome; chloride channel regulator activity; cytoplasm; endomembrane system; filopodium; glutathione transport; membrane raft; microvillus assembly; microvillus membrane; negative regulation of ERK1 and ERK2 cascade; negative regulation of cell migration; negative regulation of cell motility; negative regulation of cell proliferation; negative regulation of phosphatidylinositol 3-kinase cascade; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein kinase B signaling cascade; negative regulation of sodium ion transport; negative regulation of sodium:hydrogen antiporter activity; phospholipase C-activating dopamine receptor signaling pathway; positive regulation of intrinsic apoptotic signaling pathway; protein complex scaffold; regulation of excretion; regulation of protein kinase activity; renal phosphate ion absorption; renal sodium ion transport; ruffle; sperm midpiece IPR015098; IPR017300; IPR001478; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) Slc9a3r1 Nherf Nherf1 Rattus norvegicus (Rat) TR3830_c0_g1_i1 Q28691 PE2R4_RABIT 2.00E-19 GO:0042093; GO:0007188; GO:0071260; GO:0016021; GO:0050710; GO:2000420; GO:0050728; GO:0033624; GO:0005886; GO:0050715; GO:0050729; GO:0004957; GO:0051492 T-helper cell differentiation; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; cellular response to mechanical stimulus; integral to membrane; negative regulation of cytokine secretion; negative regulation of eosinophil extravasation; negative regulation of inflammatory response; negative regulation of integrin activation; plasma membrane; positive regulation of cytokine secretion; positive regulation of inflammatory response; prostaglandin E receptor activity; regulation of stress fiber assembly IPR000276; IPR017452; IPR001758; IPR008365; IPR001244; Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 Oryctolagus cuniculus (Rabbit) TR38302_c1_g1_i1 Q9EQP6 ARRC_MOUSE 1.00E-100 GO:0006897; GO:0002046; GO:0051219; GO:0001750; GO:0001932; GO:0007165; GO:0045202; GO:0007601 endocytosis; opsin binding; phosphoprotein binding; photoreceptor outer segment; regulation of protein phosphorylation; signal transduction; synapse; visual perception IPR000698; IPR011021; IPR014752; IPR011022; IPR017864; IPR014753; IPR014756; Arrestin-C (Cone arrestin) (cArr) (Retinal cone arrestin-3) Arr3 Mus musculus (Mouse) TR38302_c1_g1_i2 Q4R562 ARRB1_MACFA 1.00E-157 GO:0005905; GO:0016023; GO:0009968; GO:0005634; GO:0005886; GO:0001934; GO:0002092; GO:0015031; GO:0031143; GO:0006355; GO:0007165; GO:0006351 "coated pit; cytoplasmic membrane-bounded vesicle; negative regulation of signal transduction; nucleus; plasma membrane; positive regulation of protein phosphorylation; positive regulation of receptor internalization; protein transport; pseudopodium; regulation of transcription, DNA-dependent; signal transduction; transcription, DNA-dependent" IPR000698; IPR011021; IPR014752; IPR011022; IPR017864; IPR014753; IPR014756; Beta-arrestin-1 (Arrestin beta-1) ARRB1 QccE-17776 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38302_c1_g1_i4 Q4R562 ARRB1_MACFA 7.00E-157 GO:0005905; GO:0016023; GO:0009968; GO:0005634; GO:0005886; GO:0001934; GO:0002092; GO:0015031; GO:0031143; GO:0006355; GO:0007165; GO:0006351 "coated pit; cytoplasmic membrane-bounded vesicle; negative regulation of signal transduction; nucleus; plasma membrane; positive regulation of protein phosphorylation; positive regulation of receptor internalization; protein transport; pseudopodium; regulation of transcription, DNA-dependent; signal transduction; transcription, DNA-dependent" IPR000698; IPR011021; IPR014752; IPR011022; IPR017864; IPR014753; IPR014756; Beta-arrestin-1 (Arrestin beta-1) ARRB1 QccE-17776 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38302_c1_g1_i5 P36576 ARRC_RAT 4.00E-13 GO:0009968; GO:0007165; GO:0007601 negative regulation of signal transduction; signal transduction; visual perception IPR000698; IPR014752; IPR014756; Arrestin-C (Cone arrestin) (cArr) (Retinal cone arrestin-3) (Fragment) Arr3 Car Rattus norvegicus (Rat) TR38304_c1_g1_i1 Q5ZJQ8 UBAC2_CHICK 5.00E-52 GO:0016021 integral to membrane IPR009060; IPR015940; IPR000449; Ubiquitin-associated domain-containing protein 2 (UBA domain-containing protein 2) (Phosphoglycerate dehydrogenase-like protein 1) UBAC2 PHGDHL1 RCJMB04_16f18 Gallus gallus (Chicken) TR38305_c0_g1_i1 Q05AS8 DVL2_XENTR 1.00E-09 GO:0016055; GO:0032862; GO:0009948; GO:0009986; GO:0035253; GO:0042384; GO:0060027; GO:0016023; GO:0009950; GO:0046875; GO:0048013; GO:0001736; GO:0007163; GO:0001702; GO:0035556; GO:0032053; GO:0001843; GO:0022008; GO:0005634; GO:0005886; GO:0051260; GO:0050821; GO:0004871; GO:0045545 Wnt receptor signaling pathway; activation of Rho GTPase activity; anterior/posterior axis specification; cell surface; ciliary rootlet; cilium assembly; convergent extension involved in gastrulation; cytoplasmic membrane-bounded vesicle; dorsal/ventral axis specification; ephrin receptor binding; ephrin receptor signaling pathway; establishment of planar polarity; establishment or maintenance of cell polarity; gastrulation with mouth forming second; intracellular signal transduction; microtubule basal body organization; neural tube closure; neurogenesis; nucleus; plasma membrane; protein homooligomerization; protein stabilization; signal transducer activity; syndecan binding IPR000591; IPR008341; IPR024580; IPR008339; IPR003351; IPR001158; IPR015506; IPR001478; IPR011991; Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) dvl2 dsh Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38305_c0_g1_i3 Q80Y83 DIXC1_MOUSE 1.00E-60 GO:0043679; GO:0043010; GO:0060070; GO:0005938; GO:0007049; GO:0021695; GO:0021799; GO:0005829; GO:0005925; GO:0021869; GO:0043015; GO:0031435; GO:0045665; GO:0043025; GO:0046330; GO:0050772; GO:0090263; GO:0043234; GO:0046328; GO:0032956; GO:0070507; GO:0004871 axon terminus; camera-type eye development; canonical Wnt receptor signaling pathway; cell cortex; cell cycle; cerebellar cortex development; cerebral cortex radially oriented cell migration; cytosol; focal adhesion; forebrain ventricular zone progenitor cell division; gamma-tubulin binding; mitogen-activated protein kinase kinase kinase binding; negative regulation of neuron differentiation; neuronal cell body; positive regulation of JNK cascade; positive regulation of axonogenesis; positive regulation of canonical Wnt receptor signaling pathway; protein complex; regulation of JNK cascade; regulation of actin cytoskeleton organization; regulation of microtubule cytoskeleton organization; signal transducer activity IPR001715; IPR001158; IPR015506; Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) Dixdc1 Ccd1 Kiaa1735 Mus musculus (Mouse) TR38306_c0_g1_i2 P11799 MYLK_CHICK 3.00E-13 GO:0005524; GO:0005829; GO:0016020; GO:0046872; GO:0004687 ATP binding; cytosol; membrane; metal ion binding; myosin light chain kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR020675; IPR000719; IPR017441; IPR002290; IPR008271; "Myosin light chain kinase, smooth muscle (MLCK) (EC 2.7.11.18) (Telokin)" Gallus gallus (Chicken) TR38307_c4_g2_i1 Q5I0J5 MITD1_RAT 5.00E-80 GO:0000920; GO:0019898; GO:0031902; GO:0030496; GO:0000281; GO:0006810 cytokinetic cell separation; extrinsic to membrane; late endosome membrane; midbody; mitotic cytokinesis; transport IPR007330; MIT domain-containing protein 1 Mitd1 Rattus norvegicus (Rat) TR38308_c2_g2_i1 Q924H7 WAC_MOUSE 7.00E-24 GO:0044783; GO:0000993; GO:0003682; GO:0071894; GO:0010390; GO:0032435; GO:0016607; GO:0016239; GO:0045893; GO:0005681; GO:0006351 "G1 DNA damage checkpoint; RNA polymerase II core binding; chromatin binding; histone H2B conserved C-terminal lysine ubiquitination; histone monoubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; nuclear speck; positive regulation of macroautophagy; positive regulation of transcription, DNA-dependent; spliceosomal complex; transcription, DNA-dependent" IPR001202; WW domain-containing adapter protein with coiled-coil Wac Kiaa1844 Mus musculus (Mouse) TR38309_c7_g1_i1 Q8IYF3 TEX11_HUMAN 1.00E-36 GO:0000801; GO:0051026; GO:0009566; GO:0008584; GO:0007060; GO:0006311; GO:0043066; GO:0007131; GO:0000712; GO:0007130 Q96GY3; Q96FH0; Q93045 central element; chiasma assembly; fertilization; male gonad development; male meiosis chromosome segregation; meiotic gene conversion; negative regulation of apoptotic process; reciprocal meiotic recombination; resolution of meiotic recombination intermediates; synaptonemal complex assembly IPR013940; IPR011990; Testis-expressed sequence 11 protein TEX11 Homo sapiens (Human) TR38309_c8_g1_i1 Q9SSK1 SYNC3_ARATH 2.00E-72 GO:0005524; GO:0004816; GO:0006421; GO:0005829; GO:0003676 ATP binding; asparagine-tRNA ligase activity; asparaginyl-tRNA aminoacylation; cytosol; nucleic acid binding IPR004364; IPR018150; IPR006195; IPR004522; IPR002312; IPR012340; IPR004365; IPR009068; IPR000738; "Asparagine--tRNA ligase, cytoplasmic 3 (EC 6.1.1.22) (Asparaginyl-tRNA synthetase 3) (AsnRS 3)" SYNC3 At1g70980 F15H11.17 Arabidopsis thaliana (Mouse-ear cress) TR38309_c8_g1_i2 Q8BGV0 SYNM_MOUSE 6.00E-132 GO:0005524; GO:0004816; GO:0006421; GO:0005759; GO:0005739; GO:0003676 ATP binding; asparagine-tRNA ligase activity; asparaginyl-tRNA aminoacylation; mitochondrial matrix; mitochondrion; nucleic acid binding IPR004364; IPR018150; IPR006195; IPR004522; IPR002312; IPR012340; IPR004365; "Probable asparagine--tRNA ligase, mitochondrial (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS)" Nars2 Mus musculus (Mouse) TR38309_c9_g1_i1 Q7TSH8 K0195_MOUSE 1.00E-76 GO:0016021 integral to membrane IPR006068; IPR023298; Uncharacterized protein KIAA0195 Kiaa0195 Mus musculus (Mouse) TR38309_c9_g1_i3 Q7TSH8 K0195_MOUSE 2.00E-67 GO:0016021 integral to membrane IPR006068; IPR023298; Uncharacterized protein KIAA0195 Kiaa0195 Mus musculus (Mouse) TR38310_c2_g2_i3 Q5ZJP5 FND3A_CHICK 0 GO:0000139; GO:0016021 Golgi membrane; integral to membrane IPR003961; IPR013783; Fibronectin type-III domain-containing protein 3a FNDC3A FNDC3 RCJMB04_16k12 Gallus gallus (Chicken) TR38310_c2_g2_i4 Q7QB13 CCNC_ANOGA 7.00E-118 GO:0016591; GO:0000079; GO:0006355; GO:0006351 "DNA-directed RNA polymerase II, holoenzyme; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR013763; IPR015429; IPR006671; IPR023598; Cyclin-C CycC AGAP004240 Anopheles gambiae (African malaria mosquito) TR38310_c2_g2_i6 Q7QB13 CCNC_ANOGA 2.00E-133 GO:0016591; GO:0000079; GO:0006355; GO:0006351 "DNA-directed RNA polymerase II, holoenzyme; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR013763; IPR015429; IPR006671; IPR023598; Cyclin-C CycC AGAP004240 Anopheles gambiae (African malaria mosquito) TR38310_c2_g4_i1 Q5ZJP5 FND3A_CHICK 3.00E-31 GO:0000139; GO:0016021 Golgi membrane; integral to membrane IPR003961; IPR013783; Fibronectin type-III domain-containing protein 3a FNDC3A FNDC3 RCJMB04_16k12 Gallus gallus (Chicken) TR38310_c4_g1_i1 Q8IZJ3 CPMD8_HUMAN 8.00E-06 GO:0005615; GO:0010951; GO:0005886; GO:0004867 extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR002350; IPR001599; IPR019742; IPR019565; IPR022041; IPR008930; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 CPAMD8 KIAA1283 Homo sapiens (Human) TR38311_c0_g1_i1 Q8IYB5 SMAP1_HUMAN 3.00E-57 GO:0008060; GO:0005737; GO:0005886; GO:0043547; GO:0045648; GO:0032312; GO:2000369; GO:0008270 ARF GTPase activator activity; cytoplasm; plasma membrane; positive regulation of GTPase activity; positive regulation of erythrocyte differentiation; regulation of ARF GTPase activity; regulation of clathrin-mediated endocytosis; zinc ion binding IPR001164; Stromal membrane-associated protein 1 SMAP1 Homo sapiens (Human) TR38311_c0_g3_i1 Q8IYB5 SMAP1_HUMAN 1.00E-08 GO:0008060; GO:0005737; GO:0005886; GO:0043547; GO:0045648; GO:0032312; GO:2000369; GO:0008270 ARF GTPase activator activity; cytoplasm; plasma membrane; positive regulation of GTPase activity; positive regulation of erythrocyte differentiation; regulation of ARF GTPase activity; regulation of clathrin-mediated endocytosis; zinc ion binding IPR001164; Stromal membrane-associated protein 1 SMAP1 Homo sapiens (Human) TR38312_c1_g1_i3 O34939 YDIO_BACSU 1.00E-10 GO:0090116; GO:0003886; GO:0003677; GO:0009307; GO:0008168 C-5 methylation of cytosine; DNA (cytosine-5-)-methyltransferase activity; DNA binding; DNA restriction-modification system; methyltransferase activity IPR001525; Probable BsuMI modification methylase subunit YdiO (M1.BsuMI) (EC 2.1.1.37) (Cytosine-specific methyltransferase M1.BsuMI) ydiO BSU06060 Bacillus subtilis (strain 168) TR38312_c1_g1_i4 O14717 TRDMT_HUMAN 9.00E-58 GO:0003886; GO:0003677; GO:0003723; GO:0005634; GO:0001975; GO:0008033 DNA (cytosine-5-)-methyltransferase activity; DNA binding; RNA binding; nucleus; response to amphetamine; tRNA processing IPR018117; IPR001525; IPR025813; tRNA (cytosine(38)-C(5))-methyltransferase (EC 2.1.1.204) (DNA (cytosine-5)-methyltransferase-like protein 2) (Dnmt2) (DNA methyltransferase homolog HsaIIP) (DNA MTase homolog HsaIIP) (M.HsaIIP) (PuMet) TRDMT1 DNMT2 Homo sapiens (Human) TR38312_c1_g1_i5 O14717 TRDMT_HUMAN 1.00E-46 GO:0003886; GO:0003677; GO:0003723; GO:0005634; GO:0001975; GO:0008033 DNA (cytosine-5-)-methyltransferase activity; DNA binding; RNA binding; nucleus; response to amphetamine; tRNA processing IPR018117; IPR001525; IPR025813; tRNA (cytosine(38)-C(5))-methyltransferase (EC 2.1.1.204) (DNA (cytosine-5)-methyltransferase-like protein 2) (Dnmt2) (DNA methyltransferase homolog HsaIIP) (DNA MTase homolog HsaIIP) (M.HsaIIP) (PuMet) TRDMT1 DNMT2 Homo sapiens (Human) TR38313_c0_g1_i1 Q2NKR3 COXM2_BOVIN 2.00E-12 GO:0005739 mitochondrion IPR013892; COX assembly mitochondrial protein 2 homolog CMC2 Bos taurus (Bovine) TR38314_c0_g2_i1 Q2IBC0 MET_RHIFE 2.00E-50 GO:0005524; GO:0016021; GO:0007275; GO:0018108; GO:0004714; GO:0007169 ATP binding; integral to membrane; multicellular organismal development; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR013783; IPR014756; IPR002909; IPR011009; IPR016201; IPR002165; IPR000719; IPR017441; IPR001627; IPR001245; IPR008266; IPR020635; IPR016244; IPR015943; Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) MET Rhinolophus ferrumequinum (Greater horseshoe bat) TR38314_c0_g2_i2 P23049 SEA_AVIET 6.00E-54 GO:0005524; GO:0004715; GO:0018108 ATP binding; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase transforming protein SEA (EC 2.7.10.2) V-SEA Avian erythroblastosis virus (strain S13) TR38314_c0_g2_i3 P34892 KIN16_CAEEL 7.00E-36 GO:0005524; GO:0005003; GO:0048013; GO:0005887; GO:0018108 ATP binding; ephrin receptor activity; ephrin receptor signaling pathway; integral to plasma membrane; peptidyl-tyrosine phosphorylation IPR020766; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Receptor-like tyrosine-protein kinase kin-16 (EC 2.7.10.1) kin-16 M176.7 Caenorhabditis elegans TR38315_c5_g1_i1 Q12789 TF3C1_HUMAN 1.00E-32 GO:0042791; GO:0003677; GO:0005730; GO:0005654; GO:0030529; GO:0042797; GO:0000127 5S class rRNA transcription from RNA polymerase III type 1 promoter; DNA binding; nucleolus; nucleoplasm; ribonucleoprotein complex; tRNA transcription from RNA polymerase III promoter; transcription factor TFIIIC complex IPR007309; General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) GTF3C1 Homo sapiens (Human) TR38315_c5_g2_i3 Q63505 TF3C1_RAT 3.00E-19 GO:0003677; GO:0034735; GO:0006351 "DNA binding; transcription factor TFIIIC2 complex; transcription, DNA-dependent" IPR007309; General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) Gtf3c1 Rattus norvegicus (Rat) TR38315_c5_g3_i1 Q9VZW5 FMAR_DROME 5.00E-27 GO:0002209; GO:0007204; GO:0005887; GO:0008345; GO:0008188 behavioral defense response; elevation of cytosolic calcium ion concentration; integral to plasma membrane; larval locomotory behavior; neuropeptide receptor activity IPR000276; IPR017452; FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) TR38319_c8_g1_i1 O70244 CUBN_RAT 4.00E-08 GO:0031526; GO:0005509; GO:0008203; GO:0031419; GO:0030666; GO:0010008; GO:0030492; GO:0020028; GO:0042802; GO:0001701; GO:0043202; GO:0005765; GO:0043234; GO:0070207; GO:0004872; GO:0006898; GO:0007584; GO:0006766 Itself brush border membrane; calcium ion binding; cholesterol metabolic process; cobalamin binding; endocytic vesicle membrane; endosome membrane; hemoglobin binding; hemoglobin import; identical protein binding; in utero embryonic development; lysosomal lumen; lysosomal membrane; protein complex; protein homotrimerization; receptor activity; receptor-mediated endocytosis; response to nutrient; vitamin metabolic process IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; Cubilin (460 kDa receptor) (Glycoprotein 280) (gp280) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) Cubn Ifcr Rattus norvegicus (Rat) TR38319_c8_g1_i5 O70244 CUBN_RAT 1.00E-08 GO:0031526; GO:0005509; GO:0008203; GO:0031419; GO:0030666; GO:0010008; GO:0030492; GO:0020028; GO:0042802; GO:0001701; GO:0043202; GO:0005765; GO:0043234; GO:0070207; GO:0004872; GO:0006898; GO:0007584; GO:0006766 Itself brush border membrane; calcium ion binding; cholesterol metabolic process; cobalamin binding; endocytic vesicle membrane; endosome membrane; hemoglobin binding; hemoglobin import; identical protein binding; in utero embryonic development; lysosomal lumen; lysosomal membrane; protein complex; protein homotrimerization; receptor activity; receptor-mediated endocytosis; response to nutrient; vitamin metabolic process IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; Cubilin (460 kDa receptor) (Glycoprotein 280) (gp280) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) Cubn Ifcr Rattus norvegicus (Rat) TR38319_c8_g1_i7 P98070 BMP1_XENLA 1.00E-07 GO:0005794; GO:0005509; GO:0051216; GO:0030154; GO:0005615; GO:0004222; GO:0001503; GO:0005578; GO:0006508; GO:0008270 B5MFE9 Golgi apparatus; calcium ion binding; cartilage development; cell differentiation; extracellular space; metalloendopeptidase activity; ossification; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.-) bmp1 Xenopus laevis (African clawed frog) TR38320_c0_g1_i1 H2A0M3 AMO_PINMG 0 GO:0009308; GO:0005507; GO:0005576; GO:0008131; GO:0048038 amine metabolic process; copper ion binding; extracellular region; primary amine oxidase activity; quinone binding IPR000269; IPR015798; IPR016182; IPR015801; Putative amine oxidase [copper-containing] (EC 1.4.3.-) Pinctada margaritifera (Black-lipped pearl oyster) TR38323_c5_g3_i2 Q29041 FCN2_PIG 1.00E-37 GO:0005581; GO:0001867 "collagen; complement activation, lectin pathway" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) FCN2 Sus scrofa (Pig) TR38324_c3_g1_i4 P86734 EPDR1_HALAI 4.00E-12 GO:0005509; GO:0007160; GO:0005576 calcium ion binding; cell-matrix adhesion; extracellular region IPR001299; Ependymin-related protein 1 Sometsuke Haliotis asinina (Donkey's ear abalone) (Ass's ear abalone) TR38325_c2_g2_i1 A7MN07 DGOD_CROS8 3.00E-12 GO:0034194; GO:0009063; GO:0008869; GO:0000287 D-galactonate catabolic process; cellular amino acid catabolic process; galactonate dehydratase activity; magnesium ion binding IPR023592; IPR018110; IPR013342; IPR013341; IPR001354; Carbohydrate acid metabolism; D-galactonate degradation; D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 1/3. D-galactonate dehydratase (GalD) (EC 4.2.1.6) dgoD ESA_03967 Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii) TR38325_c2_g2_i2 Q6INX4 ENOF1_XENLA 3.00E-145 GO:0016853; GO:0046872; GO:0005739 isomerase activity; metal ion binding; mitochondrion IPR013342; IPR013341; IPR001354; Mitochondrial enolase superfamily member 1 (EC 5.-.-.-) enosf1 Xenopus laevis (African clawed frog) TR38325_c2_g2_i3 Q6INX4 ENOF1_XENLA 1.00E-104 GO:0016853; GO:0046872; GO:0005739 isomerase activity; metal ion binding; mitochondrion IPR013342; IPR013341; IPR001354; Mitochondrial enolase superfamily member 1 (EC 5.-.-.-) enosf1 Xenopus laevis (African clawed frog) TR38325_c2_g2_i4 A7MN07 DGOD_CROS8 2.00E-10 GO:0034194; GO:0009063; GO:0008869; GO:0000287 D-galactonate catabolic process; cellular amino acid catabolic process; galactonate dehydratase activity; magnesium ion binding IPR023592; IPR018110; IPR013342; IPR013341; IPR001354; Carbohydrate acid metabolism; D-galactonate degradation; D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 1/3. D-galactonate dehydratase (GalD) (EC 4.2.1.6) dgoD ESA_03967 Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii) TR38326_c0_g1_i1 Q6PAY8 HSDL2_XENLA 0 GO:0016491; GO:0005777; GO:0032934 oxidoreductase activity; peroxisome; sterol binding IPR002198; IPR002347; IPR016040; IPR003033; Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-) hsdl2 Xenopus laevis (African clawed frog) TR38327_c4_g3_i1 E1BD59 TRI56_BOVIN 8.00E-08 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) TR38328_c0_g1_i1 Q05793 PGBM_MOUSE 6.00E-19 GO:0005796; GO:0001525; GO:0005605; GO:0007420; GO:0048738; GO:0060351; GO:0002062; GO:0048704; GO:0001958; GO:0030198; GO:0046872; GO:0008104 Golgi lumen; angiogenesis; basal lamina; brain development; cardiac muscle tissue development; cartilage development involved in endochondral bone morphogenesis; chondrocyte differentiation; embryonic skeletal system morphogenesis; endochondral ossification; extracellular matrix organization; metal ion binding; protein localization IPR008985; IPR013320; IPR000742; IPR013032; IPR002049; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR018031; IPR000034; IPR001791; IPR023415; IPR002172; IPR000082; Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) [Cleaved into: Endorepellin; LG3 peptide] Hspg2 Mus musculus (Mouse) TR38328_c1_g1_i2 P98155 VLDLR_HUMAN 6.00E-80 GO:0034185; GO:0005509; GO:0008203; GO:0005905; GO:0034436; GO:0034437; GO:0016021; GO:0006869; GO:0005041; GO:0007613; GO:0000122; GO:0005886; GO:1900006; GO:0045860; GO:0038025; GO:0021517; GO:0034361; GO:0034189; GO:0034447; GO:0030229 apolipoprotein binding; calcium ion binding; cholesterol metabolic process; coated pit; glycoprotein transport; glycoprotein transporter activity; integral to membrane; lipid transport; low-density lipoprotein receptor activity; memory; negative regulation of transcription from RNA polymerase II promoter; plasma membrane; positive regulation of dendrite development; positive regulation of protein kinase activity; reelin receptor activity; ventral spinal cord development; very-low-density lipoprotein particle; very-low-density lipoprotein particle binding; very-low-density lipoprotein particle clearance; very-low-density lipoprotein particle receptor activity IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023415; IPR000033; IPR002172; Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) VLDLR Homo sapiens (Human) TR38328_c1_g1_i3 Q00968 EGF_PIG 2.00E-57 GO:0007262; GO:0005509; GO:0016021; GO:0043388 STAT protein import into nucleus; calcium ion binding; integral to membrane; positive regulation of DNA binding IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR000033; IPR016317; Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor] EGF Sus scrofa (Pig) TR38328_c1_g1_i4 P98157 LRP1_CHICK 8.00E-70 GO:0005509; GO:0005905; GO:0006897; GO:0016021 calcium ion binding; coated pit; endocytosis; integral to membrane IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) LRP1 Gallus gallus (Chicken) TR38328_c1_g1_i5 B4HVU2 CUE_DROSE 8.00E-17 GO:0030154; GO:0016021; GO:0048477; GO:0005886; GO:0007283 cell differentiation; integral to membrane; oogenesis; plasma membrane; spermatogenesis IPR011042; IPR000742; IPR013032; IPR000033; Protein cueball cue GM14208 Drosophila sechellia (Fruit fly) TR38328_c1_g1_i6 Q99088 LDLR2_XENLA 8.00E-76 GO:0005509; GO:0008203; GO:0005905; GO:0006897; GO:0016021; GO:0006869; GO:0034362 calcium ion binding; cholesterol metabolic process; coated pit; endocytosis; integral to membrane; lipid transport; low-density lipoprotein particle IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor 2 (LDL receptor 2) ldlr-b ldlr2 Xenopus laevis (African clawed frog) TR38331_c0_g1_i4 Q5U4F4 TM135_RAT 4.00E-53 GO:0016021; GO:0005777; GO:0007031 integral to membrane; peroxisome; peroxisome organization IPR026749; Transmembrane protein 135 (Peroxisomal membrane protein 52) (PMP52) Tmem135 Rattus norvegicus (Rat) TR38331_c0_g2_i1 Q6GQ39 TM135_XENLA 2.00E-68 GO:0016021; GO:0005777 integral to membrane; peroxisome IPR026749; Transmembrane protein 135 (Peroxisomal membrane protein 52) (PMP52) tmem135 Xenopus laevis (African clawed frog) TR38332_c1_g1_i1 Q9FVV9 NAP5_ARATH 4.00E-15 GO:0005524; GO:0042626; GO:0016021 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; integral to membrane" IPR011527; IPR003439; IPR027417; Probable non-intrinsic ABC protein 5 (MRP-related protein 2) NAP5 At1g71330 F3I17.2 Arabidopsis thaliana (Mouse-ear cress) TR38332_c2_g1_i1 P08183 MDR1_HUMAN 0 GO:0005524; GO:0042626; GO:0000086; GO:0000139; GO:0016324; GO:0009986; GO:0006855; GO:0016021; GO:0046581; GO:0072089; GO:0008559 Q86VI4; Q99496 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; G2/M transition of mitotic cell cycle; Golgi membrane; apical plasma membrane; cell surface; drug transmembrane transport; integral to membrane; intercellular canaliculus; stem cell proliferation; xenobiotic-transporting ATPase activity" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD antigen CD243) ABCB1 MDR1 PGY1 Homo sapiens (Human) TR38332_c2_g1_i3 Q54BT3 ABCB2_DICDI 0 GO:0005524; GO:0042626; GO:0016021; GO:0005886 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; plasma membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; ABC transporter B family member 2 (ABC transporter ABCB.2) abcB2 DDB_G0293438 Dictyostelium discoideum (Slime mold) TR38332_c2_g1_i4 P08183 MDR1_HUMAN 3.00E-171 GO:0005524; GO:0042626; GO:0000086; GO:0000139; GO:0016324; GO:0009986; GO:0006855; GO:0016021; GO:0046581; GO:0072089; GO:0008559 Q86VI4; Q99496 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; G2/M transition of mitotic cell cycle; Golgi membrane; apical plasma membrane; cell surface; drug transmembrane transport; integral to membrane; intercellular canaliculus; stem cell proliferation; xenobiotic-transporting ATPase activity" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD antigen CD243) ABCB1 MDR1 PGY1 Homo sapiens (Human) TR38333_c1_g1_i1 P43003 EAA1_HUMAN 1.00E-125 GO:0070779; GO:0051938; GO:0005313; GO:0031223; GO:0048667; GO:0042995; GO:0009986; GO:0021545; GO:0043205; GO:0009449; GO:0016595; GO:0006537; GO:0005314; GO:0016021; GO:0050885; GO:0043025; GO:0001504; GO:0005886; GO:0050806; GO:0046677; GO:0042493; GO:0009416; GO:0009611; GO:0007605; GO:0017153 D-aspartate import; L-glutamate import; L-glutamate transmembrane transporter activity; auditory behavior; cell morphogenesis involved in neuron differentiation; cell projection; cell surface; cranial nerve development; fibril; gamma-aminobutyric acid biosynthetic process; glutamate binding; glutamate biosynthetic process; high-affinity glutamate transmembrane transporter activity; integral to membrane; neuromuscular process controlling balance; neuronal cell body; neurotransmitter uptake; plasma membrane; positive regulation of synaptic transmission; response to antibiotic; response to drug; response to light stimulus; response to wounding; sensory perception of sound; sodium:dicarboxylate symporter activity IPR001991; IPR018107; Excitatory amino acid transporter 1 (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3) SLC1A3 EAAT1 GLAST GLAST1 Homo sapiens (Human) TR38333_c1_g1_i2 P51906 EAA3_MOUSE 2.00E-133 GO:0070779; GO:0051938; GO:0016595; GO:0015501; GO:0016021; GO:0005886; GO:0051260; GO:0017153 P53702 D-aspartate import; L-glutamate import; glutamate binding; glutamate:sodium symporter activity; integral to membrane; plasma membrane; protein homooligomerization; sodium:dicarboxylate symporter activity IPR001991; IPR018107; Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1) Slc1a1 Eaac1 Eaat3 Mus musculus (Mouse) TR38335_c0_g1_i1 Q4R366 MRRP3_MACFA 2.00E-14 GO:0005739; GO:0008033 mitochondrion; tRNA processing IPR026318; Mitochondrial ribonuclease P protein 3 (Mitochondrial RNase P protein 3) MRPP3 QtsA-19281 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38335_c0_g1_i4 O15091 MRRP3_HUMAN 2.00E-30 GO:0005739; GO:0008033 mitochondrion; tRNA processing IPR026318; Mitochondrial ribonuclease P protein 3 (Mitochondrial RNase P protein 3) KIAA0391 MRPP3 Homo sapiens (Human) TR38336_c2_g1_i4 Q9CR80 FA32A_MOUSE 4.00E-19 GO:0006915; GO:0007049; GO:0005730 apoptotic process; cell cycle; nucleolus IPR013865; Protein FAM32A (Ovarian tumor associated gene 12) (OTAG-12) Fam32a Otag12 MNCb-3154 Mus musculus (Mouse) TR38338_c0_g1_i1 Q92536 YLAT2_HUMAN 2.00E-98 GO:0015171; GO:0015297; GO:0016323; GO:0007596; GO:0006520; GO:0005887; GO:0050900; GO:0006461 amino acid transmembrane transporter activity; antiporter activity; basolateral plasma membrane; blood coagulation; cellular amino acid metabolic process; integral to plasma membrane; leukocyte migration; protein complex assembly IPR002293; "Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)" SLC7A6 KIAA0245 Homo sapiens (Human) TR38338_c0_g1_i2 Q9WTR6 XCT_MOUSE 2.00E-98 GO:0015171; GO:0016021; GO:0070527; GO:0009636 amino acid transmembrane transporter activity; integral to membrane; platelet aggregation; response to toxic substance IPR002293; IPR004760; Cystine/glutamate transporter (Amino acid transport system xc-) (Solute carrier family 7 member 11) (xCT) Slc7a11 Mus musculus (Mouse) TR38338_c0_g1_i3 Q8MH63 LAT1N_HUMAN 2.00E-26 GO:0015171; GO:0016021 amino acid transmembrane transporter activity; integral to membrane IPR002293; Putative L-type amino acid transporter 1-like protein MLAS (hLAT1 3-transmembrane protein MLAS) (hLAT1 3TM MLAS) SLC7A5P1 MLAS Homo sapiens (Human) TR38339_c10_g1_i1 O95714 HERC2_HUMAN 3.00E-18 GO:0006281; GO:0032183; GO:0005814; GO:0005737; GO:0005085; GO:0020037; GO:0006886; GO:0005634; GO:0042787; GO:0004842; GO:0008270 DNA repair; SUMO binding; centriole; cytoplasm; guanyl-nucleotide exchange factor activity; heme binding; intracellular protein transport; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR004939; IPR006624; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) HERC2 Homo sapiens (Human) TR38339_c5_g1_i1 Q9V4N3 CYB5_DROME 6.00E-14 GO:0005789; GO:0020037; GO:0016021; GO:0005811; GO:0046872; GO:0055114; GO:0045610; GO:0035206 endoplasmic reticulum membrane; heme binding; integral to membrane; lipid particle; metal ion binding; oxidation-reduction process; regulation of hemocyte differentiation; regulation of hemocyte proliferation IPR001199; IPR018506; Cytochrome b5 (CYTB5) Cyt-b5 CG2140 Drosophila melanogaster (Fruit fly) TR38339_c6_g1_i1 Q9BVR0 HRC23_HUMAN 2.00E-89 GO:0046872; GO:0004842 metal ion binding; ubiquitin-protein ligase activity IPR010606; Putative HERC2-like protein 3 HERC2P3 Homo sapiens (Human) TR38339_c8_g2_i1 Q4U2R1 HERC2_MOUSE 0 GO:0006281; GO:0032183; GO:0005814; GO:0020037; GO:0005743; GO:0005634; GO:0042787; GO:0007283; GO:0004842; GO:0008270 DNA repair; SUMO binding; centriole; heme binding; mitochondrial inner membrane; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; spermatogenesis; ubiquitin-protein ligase activity; zinc ion binding IPR004939; IPR006624; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) Herc2 Jdf2 Kiaa0393 Rjs Mus musculus (Mouse) TR38339_c8_g2_i2 Q9VR91 HERC2_DROME 0 GO:0005814; GO:0005737; GO:0020037; GO:0046872; GO:0005634; GO:0042787; GO:0004842 centriole; cytoplasm; heme binding; metal ion binding; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR004939; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR009060; IPR015940; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) HERC2 CG11734 Drosophila melanogaster (Fruit fly) TR38339_c8_g3_i1 Q4U2R1 HERC2_MOUSE 0 GO:0006281; GO:0032183; GO:0005814; GO:0020037; GO:0005743; GO:0005634; GO:0042787; GO:0007283; GO:0004842; GO:0008270 DNA repair; SUMO binding; centriole; heme binding; mitochondrial inner membrane; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; spermatogenesis; ubiquitin-protein ligase activity; zinc ion binding IPR004939; IPR006624; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) Herc2 Jdf2 Kiaa0393 Rjs Mus musculus (Mouse) TR38339_c8_g3_i2 Q4U2R1 HERC2_MOUSE 0 GO:0006281; GO:0032183; GO:0005814; GO:0020037; GO:0005743; GO:0005634; GO:0042787; GO:0007283; GO:0004842; GO:0008270 DNA repair; SUMO binding; centriole; heme binding; mitochondrial inner membrane; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; spermatogenesis; ubiquitin-protein ligase activity; zinc ion binding IPR004939; IPR006624; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) Herc2 Jdf2 Kiaa0393 Rjs Mus musculus (Mouse) TR38339_c8_g3_i3 Q9VR91 HERC2_DROME 0 GO:0005814; GO:0005737; GO:0020037; GO:0046872; GO:0005634; GO:0042787; GO:0004842 centriole; cytoplasm; heme binding; metal ion binding; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR004939; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR009060; IPR015940; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) HERC2 CG11734 Drosophila melanogaster (Fruit fly) TR38339_c8_g3_i4 Q4U2R1 HERC2_MOUSE 0 GO:0006281; GO:0032183; GO:0005814; GO:0020037; GO:0005743; GO:0005634; GO:0042787; GO:0007283; GO:0004842; GO:0008270 DNA repair; SUMO binding; centriole; heme binding; mitochondrial inner membrane; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; spermatogenesis; ubiquitin-protein ligase activity; zinc ion binding IPR004939; IPR006624; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) Herc2 Jdf2 Kiaa0393 Rjs Mus musculus (Mouse) TR38341_c0_g1_i1 P14381 YTX2_XENLA 2.00E-48 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR38341_c0_g1_i2 P16423 POLR_DROME 3.00E-10 GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0046872; GO:0090305; GO:0006508 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR000477; IPR007087; IPR015880; Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM (Retrovirus-related Pol polyprotein from type II retrotransposable element R2DM) [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR38342_c7_g2_i1 Q6XSH4 TCTP_LATJA 9.00E-38 GO:0005737 cytoplasm IPR011057; IPR011323; IPR018103; IPR018105; Translationally-controlled tumor protein homolog (TCTP) tpt1 tctp Lateolabrax japonicus (Japanese sea perch) (Japanese sea bass) TR38343_c0_g2_i1 Q9SCB9 VATC_HORVU 2.00E-61 GO:0015991; GO:0015078; GO:0033180; GO:0005774 "ATP hydrolysis coupled proton transport; hydrogen ion transmembrane transporter activity; proton-transporting V-type ATPase, V1 domain; vacuolar membrane" IPR004907; V-type proton ATPase subunit C (V-ATPase subunit C) (Vacuolar proton pump subunit C) VATC ATC Hordeum vulgare (Barley) TR38343_c0_g2_i4 Q7T385 VTC1A_DANRE 0 GO:0015991; GO:0015078; GO:0033180 "ATP hydrolysis coupled proton transport; hydrogen ion transmembrane transporter activity; proton-transporting V-type ATPase, V1 domain" IPR004907; V-type proton ATPase subunit C 1-A (V-ATPase subunit C 1-A) (Vacuolar proton pump subunit C 1-A) atp6v1c1a atp6v1c1 zgc:64034 Danio rerio (Zebrafish) (Brachydanio rerio) TR38344_c0_g1_i1 Q91ZN7 CHK1_RAT 0 GO:0005524; GO:0000077; GO:0006975; GO:0006281; GO:0071313; GO:0071260; GO:0005813; GO:0000785; GO:0048096; GO:0000781; GO:0000794; GO:0005737; GO:0035402; GO:0045839; GO:0010569; GO:2000615; GO:0046602; GO:0010767 "ATP binding; DNA damage checkpoint; DNA damage induced protein phosphorylation; DNA repair; cellular response to caffeine; cellular response to mechanical stimulus; centrosome; chromatin; chromatin-mediated maintenance of transcription; chromosome, telomeric region; condensed nuclear chromosome; cytoplasm; histone kinase activity (H3-T11 specific); negative regulation of mitosis; regulation of double-strand break repair via homologous recombination; regulation of histone H3-K9 acetylation; regulation of mitotic centrosome separation; regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Checkpoint kinase-1) Chek1 Chk1 Rattus norvegicus (Rat) TR38344_c0_g1_i2 Q91ZN7 CHK1_RAT 0 GO:0005524; GO:0000077; GO:0006975; GO:0006281; GO:0071313; GO:0071260; GO:0005813; GO:0000785; GO:0048096; GO:0000781; GO:0000794; GO:0005737; GO:0035402; GO:0045839; GO:0010569; GO:2000615; GO:0046602; GO:0010767 "ATP binding; DNA damage checkpoint; DNA damage induced protein phosphorylation; DNA repair; cellular response to caffeine; cellular response to mechanical stimulus; centrosome; chromatin; chromatin-mediated maintenance of transcription; chromosome, telomeric region; condensed nuclear chromosome; cytoplasm; histone kinase activity (H3-T11 specific); negative regulation of mitosis; regulation of double-strand break repair via homologous recombination; regulation of histone H3-K9 acetylation; regulation of mitotic centrosome separation; regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Checkpoint kinase-1) Chek1 Chk1 Rattus norvegicus (Rat) TR38345_c0_g1_i3 Q8QZS3 FLCN_MOUSE 1.00E-150 GO:0031929; GO:0007043; GO:0005737; GO:0030097; GO:0001701; GO:2001170; GO:0070373; GO:0035024; GO:0032007; GO:0016525; GO:0030308; GO:0030336; GO:1901723; GO:1901856; GO:2000506; GO:1901859; GO:0010823; GO:1901862; GO:1901874; GO:0051898; GO:1900181; GO:0000122; GO:0005634; GO:0005886; GO:0032008; GO:0045785; GO:2001244; GO:0001934; GO:0045944; GO:0030511; GO:0032403; GO:0032465; GO:0035065; GO:2000973 Q68FD7 TOR signaling cascade; cell-cell junction assembly; cytoplasm; hemopoiesis; in utero embryonic development; negative regulation of ATP biosynthetic process; negative regulation of ERK1 and ERK2 cascade; negative regulation of Rho protein signal transduction; negative regulation of TOR signaling cascade; negative regulation of angiogenesis; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell proliferation involved in kidney development; negative regulation of cellular respiration; negative regulation of energy homeostasis; negative regulation of mitochondrial DNA metabolic process; negative regulation of mitochondrion organization; negative regulation of muscle tissue development; negative regulation of post-translational protein modification; negative regulation of protein kinase B signaling cascade; negative regulation of protein localization to nucleus; negative regulation of transcription from RNA polymerase II promoter; nucleus; plasma membrane; positive regulation of TOR signaling cascade; positive regulation of cell adhesion; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor beta receptor signaling pathway; protein complex binding; regulation of cytokinesis; regulation of histone acetylation; regulation of pro-B cell differentiation IPR021713; Folliculin Flcn Mus musculus (Mouse) TR38347_c0_g1_i1 O35210 AGTR1_MERUN 2.00E-09 GO:0004945; GO:0016021; GO:0005886; GO:0019229 angiotensin type II receptor activity; integral to membrane; plasma membrane; regulation of vasoconstriction IPR000190; IPR000248; IPR000276; IPR017452; Type-1 angiotensin II receptor (Angiotensin II type-1 receptor) (AT1) (GkAT1) AGTR1 Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) TR38347_c0_g1_i2 Q5D0K2 CCKAR_CANFA 3.00E-10 GO:0007409; GO:0004951; GO:0038188; GO:0030900; GO:0016021; GO:0001764; GO:0005886 axonogenesis; cholecystokinin receptor activity; cholecystokinin signaling pathway; forebrain development; integral to membrane; neuron migration; plasma membrane IPR009126; IPR000596; IPR015276; IPR000276; IPR017452; Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR Canis familiaris (Dog) (Canis lupus familiaris) TR38347_c0_g1_i3 P29404 OPS4_DROPS 4.00E-06 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR000856; IPR027430; Opsin Rh4 (Inner R7 photoreceptor cells opsin) Rh4 GA28288 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR38347_c0_g1_i4 Q5D0K2 CCKAR_CANFA 4.00E-11 GO:0007409; GO:0004951; GO:0038188; GO:0030900; GO:0016021; GO:0001764; GO:0005886 axonogenesis; cholecystokinin receptor activity; cholecystokinin signaling pathway; forebrain development; integral to membrane; neuron migration; plasma membrane IPR009126; IPR000596; IPR015276; IPR000276; IPR017452; Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR Canis familiaris (Dog) (Canis lupus familiaris) TR38349_c1_g1_i2 P51406 BYS_DROME 3.00E-66 GO:0022008; GO:0005730; GO:0005634; GO:0042254 neurogenesis; nucleolus; nucleus; ribosome biogenesis IPR007955; Bystin (Protein bys) bys CG1430 Drosophila melanogaster (Fruit fly) TR38349_c1_g2_i1 Q20932 BYN1_CAEEL 1.00E-61 GO:0007155 cell adhesion IPR007955; Cell adhesion protein byn-1 byn-1 F57B9.5 Caenorhabditis elegans TR38349_c1_g2_i2 Q5E9N0 BYST_BOVIN 3.00E-90 GO:0045177; GO:0008283; GO:0005737; GO:0000462; GO:0005730; GO:0001829 "apical part of cell; cell proliferation; cytoplasm; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleolus; trophectodermal cell differentiation" IPR007955; Bystin BYSL Bos taurus (Bovine) TR38351_c4_g1_i3 Q54YP4 VPS11_DICDI 5.00E-06 GO:0030897; GO:0006886; GO:0042144; GO:0016192; GO:0008270 "HOPS complex; intracellular protein transport; vacuole fusion, non-autophagic; vesicle-mediated transport; zinc ion binding" IPR016024; IPR000547; IPR016528; IPR024763; IPR015943; IPR017986; IPR001841; IPR013083; Vacuolar protein sorting-associated protein 11 homolog vps11 pep5 DDB_G0278141 Dictyostelium discoideum (Slime mold) TR38351_c4_g1_i4 P59015 VPS18_DANRE 0 GO:0045176; GO:0015721; GO:0008333; GO:0043485; GO:0048069; GO:0006886; GO:0031902; GO:0005765; GO:0060036; GO:0007634; GO:0016192; GO:0008270 apical protein localization; bile acid and bile salt transport; endosome to lysosome transport; endosome to pigment granule transport; eye pigmentation; intracellular protein transport; late endosome membrane; lysosomal membrane; notochord cell vacuolation; optokinetic behavior; vesicle-mediated transport; zinc ion binding IPR000547; IPR007810; IPR001841; Vacuolar protein sorting-associated protein 18 homolog vps18 Danio rerio (Zebrafish) (Brachydanio rerio) TR38351_c4_g1_i6 P59015 VPS18_DANRE 0 GO:0045176; GO:0015721; GO:0008333; GO:0043485; GO:0048069; GO:0006886; GO:0031902; GO:0005765; GO:0060036; GO:0007634; GO:0016192; GO:0008270 apical protein localization; bile acid and bile salt transport; endosome to lysosome transport; endosome to pigment granule transport; eye pigmentation; intracellular protein transport; late endosome membrane; lysosomal membrane; notochord cell vacuolation; optokinetic behavior; vesicle-mediated transport; zinc ion binding IPR000547; IPR007810; IPR001841; Vacuolar protein sorting-associated protein 18 homolog vps18 Danio rerio (Zebrafish) (Brachydanio rerio) TR38352_c1_g1_i1 Q03567 YLD2_CAEEL 7.00E-95 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR011701; IPR020846; IPR016196; Uncharacterized transporter C38C10.2 C38C10.2 Caenorhabditis elegans TR38352_c1_g1_i2 P34644 EAT4_CAEEL 2.00E-52 GO:0030054; GO:0016021; GO:0061096; GO:0006836; GO:0005886; GO:0043051; GO:0006814; GO:0015293; GO:0045202 cell junction; integral to membrane; negative regulation of turning behavior involved in mating; neurotransmitter transport; plasma membrane; regulation of pharyngeal pumping; sodium ion transport; symporter activity; synapse IPR011701; IPR020846; IPR016196; Probable vesicular glutamate transporter eat-4 (Abnormal pharyngeal pumping eat-4) eat-4 ZK512.6 Caenorhabditis elegans TR38352_c1_g1_i3 Q9NRA2 S17A5_HUMAN 3.00E-98 GO:0006865; GO:0030054; GO:0005887; GO:0005765; GO:0015136; GO:0015739; GO:0005351; GO:0030672 amino acid transport; cell junction; integral to plasma membrane; lysosomal membrane; sialic acid transmembrane transporter activity; sialic acid transport; sugar:hydrogen symporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) TR38353_c3_g1_i1 Q92752 TENR_HUMAN 2.00E-54 GO:0008306; GO:0007411; GO:0007155; GO:0009986; GO:0005737; GO:0030198; GO:0005576; GO:0035641; GO:0060291; GO:0045121; GO:0048692; GO:0022408; GO:0050805; GO:0050885; GO:0007158; GO:0005634; GO:0072534; GO:0051968; GO:0005578; GO:0050808; GO:0022029 "associative learning; axon guidance; cell adhesion; cell surface; cytoplasm; extracellular matrix organization; extracellular region; locomotory exploration behavior; long-term synaptic potentiation; membrane raft; negative regulation of axon extension involved in regeneration; negative regulation of cell-cell adhesion; negative regulation of synaptic transmission; neuromuscular process controlling balance; neuron cell-cell adhesion; nucleus; perineuronal net; positive regulation of synaptic transmission, glutamatergic; proteinaceous extracellular matrix; synapse organization; telencephalon cell migration" IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin-R (TN-R) (Janusin) (Restrictin) TNR Homo sapiens (Human) TR38353_c3_g1_i10 Q80YX1 TENA_MOUSE 6.00E-54 GO:0005604; GO:0007155; GO:0005615; GO:0005614; GO:0060739; GO:0007528; GO:0014012; GO:0008284; GO:0010628; GO:0060740; GO:0045545 basement membrane; cell adhesion; extracellular space; interstitial matrix; mesenchymal-epithelial cell signaling involved in prostate gland development; neuromuscular junction development; peripheral nervous system axon regeneration; positive regulation of cell proliferation; positive regulation of gene expression; prostate gland epithelium morphogenesis; syndecan binding IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin (TN) (Hexabrachion) (Tenascin-C) (TN-C) Tnc Hxb Mus musculus (Mouse) TR38353_c3_g1_i11 O75636 FCN3_HUMAN 1.00E-54 GO:0030246; GO:0005581; GO:0001867; GO:0005576 "carbohydrate binding; collagen; complement activation, lectin pathway; extracellular region" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-3 (Collagen/fibrinogen domain-containing lectin 3 p35) (Collagen/fibrinogen domain-containing protein 3) (Hakata antigen) FCN3 FCNH HAKA1 Homo sapiens (Human) TR38353_c3_g1_i2 Q9U8W8 TL5A_TACTR 3.00E-50 GO:0030246; GO:0016337; GO:0005576; GO:0046872 carbohydrate binding; cell-cell adhesion; extracellular region; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Techylectin-5A Tachypleus tridentatus (Japanese horseshoe crab) TR38353_c3_g1_i5 Q6AX44 FBCDA_XENLA 1.00E-56 GO:0008061; GO:0016021; GO:0046872 chitin binding; integral to membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1-A fibcd1-a Xenopus laevis (African clawed frog) TR38353_c3_g1_i6 Q9WTS8 FCN1_RAT 4.00E-52 GO:0005581; GO:0045087; GO:0046872 collagen; innate immune response; metal ion binding IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) Fcn1 Fcna Rattus norvegicus (Rat) TR38353_c3_g1_i7 Q8N539 FBCD1_HUMAN 9.00E-62 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 UNQ701/PRO1346 Homo sapiens (Human) TR38353_c3_g1_i8 Q80Z71 TENN_MOUSE 2.00E-44 GO:0007409; GO:0016049; GO:0016477; GO:0009986; GO:0007160; GO:0042802; GO:0005178; GO:0005578 axonogenesis; cell growth; cell migration; cell surface; cell-matrix adhesion; identical protein binding; integrin binding; proteinaceous extracellular matrix IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR020837; IPR003961; IPR013783; Tenascin-N (TN-N) Tnn Mus musculus (Mouse) TR38353_c3_g1_i9 Q15485 FCN2_HUMAN 1.00E-58 GO:0003823; GO:0005509; GO:0030246; GO:0005581; GO:0001867; GO:0005576; GO:0008228 Q07954 "antigen binding; calcium ion binding; carbohydrate binding; collagen; complement activation, lectin pathway; extracellular region; opsonization" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-2 (37 kDa elastin-binding protein) (Collagen/fibrinogen domain-containing protein 2) (EBP-37) (Ficolin-B) (Ficolin-beta) (Hucolin) (L-ficolin) (Serum lectin p35) FCN2 FCNL Homo sapiens (Human) TR38355_c2_g1_i1 P41596 DOPR1_DROME 3.00E-10 GO:0007191; GO:0071329; GO:0001588; GO:0005887; GO:0007613; GO:0090328; GO:0042594; GO:0040040; GO:0043052; GO:0008542 "adenylate cyclase-activating dopamine receptor signaling pathway; cellular response to sucrose stimulus; dopamine neurotransmitter receptor activity, coupled via Gs; integral to plasma membrane; memory; regulation of olfactory learning; response to starvation; thermosensory behavior; thermotaxis; visual learning" IPR000929; IPR000276; IPR017452; Dopamine receptor 1 (D-DOP1) (DmDop1) (dDA1) DopR DopR1 DopR35EF CG9652 Drosophila melanogaster (Fruit fly) TR38355_c2_g1_i2 Q923Y4 TAA7H_RAT 6.00E-18 GO:0016021; GO:0005886; GO:0001594 integral to membrane; plasma membrane; trace-amine receptor activity IPR000276; IPR017452; IPR009132; Trace amine-associated receptor 7h (TaR-7h) (Trace amine receptor 7h) (Trace amine receptor 6) (TaR-6) Taar7h Ta6 Tar6 Trar6 Rattus norvegicus (Rat) TR38355_c2_g1_i3 Q5QD04 TAAR9_MOUSE 2.00E-13 GO:0016021; GO:0005886; GO:0001594 integral to membrane; plasma membrane; trace-amine receptor activity IPR000276; IPR017452; IPR009132; Trace amine-associated receptor 9 (TaR-9) (Trace amine receptor 9) (mTaar9) Taar9 Mus musculus (Mouse) TR38355_c2_g1_i4 Q923Y4 TAA7H_RAT 3.00E-18 GO:0016021; GO:0005886; GO:0001594 integral to membrane; plasma membrane; trace-amine receptor activity IPR000276; IPR017452; IPR009132; Trace amine-associated receptor 7h (TaR-7h) (Trace amine receptor 7h) (Trace amine receptor 6) (TaR-6) Taar7h Ta6 Tar6 Trar6 Rattus norvegicus (Rat) TR38357_c0_g1_i10 P20290 BTF3_HUMAN 2.00E-54 GO:0001701; GO:0005634; GO:0006355; GO:0006366 P03372 "in utero embryonic development; nucleus; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter" IPR002715; Transcription factor BTF3 (RNA polymerase B transcription factor 3) BTF3 NACB OK/SW-cl.8 Homo sapiens (Human) TR38357_c0_g1_i11 Q6PC91 BT3L4_DANRE 9.00E-58 IPR002715; Transcription factor BTF3 homolog 4 (Basic transcription factor 3-like 4) btf3l4 Danio rerio (Zebrafish) (Brachydanio rerio) TR38357_c0_g1_i2 P20290 BTF3_HUMAN 8.00E-53 GO:0001701; GO:0005634; GO:0006355; GO:0006366 P03372 "in utero embryonic development; nucleus; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter" IPR002715; Transcription factor BTF3 (RNA polymerase B transcription factor 3) BTF3 NACB OK/SW-cl.8 Homo sapiens (Human) TR38357_c0_g1_i3 Q6PC91 BT3L4_DANRE 4.00E-59 IPR002715; Transcription factor BTF3 homolog 4 (Basic transcription factor 3-like 4) btf3l4 Danio rerio (Zebrafish) (Brachydanio rerio) TR38357_c0_g1_i8 Q0ULD0 NACB_PHANO 5.00E-35 GO:0005737; GO:0005634; GO:0015031; GO:0006355; GO:0006351 "cytoplasm; nucleus; protein transport; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002715; Nascent polypeptide-associated complex subunit beta (NAC-beta) (Beta-NAC) EGD1 SNOG_07434 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum) TR38359_c0_g1_i2 B0JZG0 S23A2_XENTR 8.00E-159 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR006042; IPR006043; Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38359_c0_g1_i5 B0JZG0 S23A2_XENTR 3.00E-160 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR006042; IPR006043; Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38361_c0_g1_i1 Q49B93 SC5AC_MOUSE 2.00E-145 GO:0016324; GO:0016021; GO:0006814; GO:0015293 apical plasma membrane; integral to membrane; sodium ion transport; symporter activity IPR001734; IPR019900; Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12) Slc5a12 Smct2 Mus musculus (Mouse) TR38361_c0_g1_i2 Q49B93 SC5AC_MOUSE 6.00E-148 GO:0016324; GO:0016021; GO:0006814; GO:0015293 apical plasma membrane; integral to membrane; sodium ion transport; symporter activity IPR001734; IPR019900; Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12) Slc5a12 Smct2 Mus musculus (Mouse) TR38362_c0_g1_i3 Q9CYC6 DCP2_MOUSE 4.00E-100 GO:0016442; GO:0003723; GO:0000932; GO:0071044; GO:0050072; GO:0030145; GO:0000184; GO:0005634 "RISC complex; RNA binding; cytoplasmic mRNA processing body; histone mRNA catabolic process; m7G(5')pppN diphosphatase activity; manganese ion binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus" IPR007722; IPR020084; IPR000086; IPR015797; m7GpppN-mRNA hydrolase (EC 3.6.1.62) (mRNA-decapping enzyme 2) Dcp2 Mus musculus (Mouse) TR38363_c4_g1_i1 Q10126 YSM6_CAEEL 5.00E-06 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR000477; Putative uncharacterized transposon-derived protein F52C9.6 F52C9.6 Caenorhabditis elegans TR38364_c0_g1_i1 P21163 PNGF_ELIMR 7.00E-07 GO:0016715; GO:0000224 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity" IPR014784; IPR008977; IPR015197; IPR015196; Peptide-N(4)-(N-acetyl-beta-D-glucosaminyl)asparagine amidase F (PNGase F) (EC 3.5.1.52) (Glycopeptide N-glycosidase) (N-glycanase) ngl png Elizabethkingia miricola (Chryseobacterium miricola) TR38366_c3_g1_i1 Q9XXA7 NEUFC_CAEEL 2.00E-48 GO:0005576; GO:0020037 extracellular region; heme binding IPR001199; Neuferricin homolog (Cytochrome b5 domain-containing protein 2 homolog) tag-131 H38K22.3 Caenorhabditis elegans TR38366_c3_g1_i2 Q5SSH8 NEUFC_MOUSE 2.00E-64 GO:0005576; GO:0020037; GO:0007399 extracellular region; heme binding; nervous system development IPR001199; Neuferricin (Cytochrome b5 domain-containing protein 2) Cyb5d2 Mus musculus (Mouse) TR38367_c1_g1_i1 A5PLH4 TM2D1_DANRE 2.00E-29 GO:0016021 integral to membrane IPR007829; TM2 domain-containing protein 1 tm2d1 si:ch211-112f11.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR38368_c0_g2_i1 Q9HCI7 MSL2_HUMAN 3.00E-32 GO:0072487; GO:0043984; GO:0016874; GO:0008270 MSL complex; histone H4-K16 acetylation; ligase activity; zinc ion binding IPR001841; E3 ubiquitin-protein ligase MSL2 (EC 6.3.2.-) (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184) MSL2 KIAA1585 MSL2L1 RNF184 Homo sapiens (Human) TR38370_c1_g1_i1 O75746 CMC1_HUMAN 2.00E-119 GO:0015183; GO:0005313; GO:0005509; GO:0006094; GO:0016021; GO:0043490; GO:0005743; GO:0051592; GO:0044281 L-aspartate transmembrane transporter activity; L-glutamate transmembrane transporter activity; calcium ion binding; gluconeogenesis; integral to membrane; malate-aspartate shuttle; mitochondrial inner membrane; response to calcium ion; small molecule metabolic process IPR011992; IPR018247; IPR002048; IPR002067; IPR018108; IPR023395; Calcium-binding mitochondrial carrier protein Aralar1 (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12) SLC25A12 ARALAR1 Homo sapiens (Human) TR38371_c1_g1_i1 Q54NA6 MYBL_DICDI 1.00E-27 GO:0003677; GO:0003682; GO:0005634; GO:0006355; GO:0006351 "DNA binding; chromatin binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009057; IPR017877; IPR017930; IPR001005; Myb-like protein L mybL DDB_G0285373 Dictyostelium discoideum (Slime mold) TR38371_c5_g1_i2 Q66T72 PSIP1_FELCA 1.00E-38 GO:0001105; GO:0033613; GO:0003682; GO:0000395; GO:0005720; GO:0009408; GO:0006979; GO:0097100; GO:0035327 RNA polymerase II transcription coactivator activity; activating transcription factor binding; chromatin binding; mRNA 5'-splice site recognition; nuclear heterochromatin; response to heat; response to oxidative stress; supercoiled DNA binding; transcriptionally active chromatin IPR021567; IPR000313; IPR017859; PC4 and SFRS1-interacting protein (LEDGF/p75) (Lens epithelium-derived growth factor) (Transcription coactivator p75) PSIP1 LEDGF Felis catus (Cat) (Felis silvestris catus) TR38372_c1_g1_i1 Q66JT1 LRC8E_MOUSE 7.00E-11 GO:0016021 integral to membrane IPR001611; IPR003591; IPR021040; Leucine-rich repeat-containing protein 8E Lrrc8e Mus musculus (Mouse) TR38372_c3_g1_i1 Q07832 PLK1_MOUSE 8.00E-150 GO:0005524; GO:0031572; GO:0000086; GO:0007092; GO:0005813; GO:0051297; GO:0000942; GO:0000910; GO:0005737; GO:0000776; GO:0008017; GO:0001578; GO:0030496; GO:0000070; GO:0007094; GO:0043066; GO:0045736; GO:0000122; GO:0005634; GO:0018105; GO:0010800; GO:0031648; GO:0071168; GO:0004674; GO:0016567; GO:0043393; GO:0005876; GO:0051233; GO:0000922 ATP binding; G2 DNA damage checkpoint; G2/M transition of mitotic cell cycle; activation of mitotic anaphase-promoting complex activity; centrosome; centrosome organization; condensed nuclear chromosome outer kinetochore; cytokinesis; cytoplasm; kinetochore; microtubule binding; microtubule bundle formation; midbody; mitotic sister chromatid segregation; mitotic spindle assembly checkpoint; negative regulation of apoptotic process; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of transcription from RNA polymerase II promoter; nucleus; peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; protein destabilization; protein localization to chromatin; protein serine/threonine kinase activity; protein ubiquitination; regulation of protein binding; spindle microtubule; spindle midzone; spindle pole IPR011009; IPR000959; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) Plk1 Plk Mus musculus (Mouse) TR38372_c3_g1_i10 Q9NYY3 PLK2_HUMAN 3.00E-157 GO:0005524; GO:0000082; GO:0032486; GO:0005814; GO:0030425; GO:0060292; GO:0060291; GO:0007613; GO:0007093; GO:0007052; GO:0043066; GO:0043123; GO:0004674; GO:0046599; GO:0004871 Q9HC77 ATP binding; G1/S transition of mitotic cell cycle; Rap protein signal transduction; centriole; dendrite; long term synaptic depression; long-term synaptic potentiation; memory; mitotic cell cycle checkpoint; mitotic spindle organization; negative regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein serine/threonine kinase activity; regulation of centriole replication; signal transducer activity IPR011009; IPR000959; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 2) (PLK-2) (hPlk2) (Serine/threonine-protein kinase SNK) (hSNK) (Serum-inducible kinase) PLK2 SNK Homo sapiens (Human) TR38372_c3_g1_i2 Q2TA25 PLK1_BOVIN 2.00E-39 GO:0005524; GO:0031572; GO:0000086; GO:0007092; GO:0005813; GO:0051297; GO:0000942; GO:0000910; GO:0005737; GO:0000776; GO:0008017; GO:0001578; GO:0030496; GO:0000070; GO:0007094; GO:0043066; GO:0045736; GO:0000122; GO:0005634; GO:0018105; GO:0010800; GO:0031648; GO:0071168; GO:0004674; GO:0016567; GO:0043393; GO:0005876; GO:0051233; GO:0000922 ATP binding; G2 DNA damage checkpoint; G2/M transition of mitotic cell cycle; activation of mitotic anaphase-promoting complex activity; centrosome; centrosome organization; condensed nuclear chromosome outer kinetochore; cytokinesis; cytoplasm; kinetochore; microtubule binding; microtubule bundle formation; midbody; mitotic sister chromatid segregation; mitotic spindle assembly checkpoint; negative regulation of apoptotic process; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of transcription from RNA polymerase II promoter; nucleus; peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; protein destabilization; protein localization to chromatin; protein serine/threonine kinase activity; protein ubiquitination; regulation of protein binding; spindle microtubule; spindle midzone; spindle pole IPR011009; IPR000959; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) PLK1 Bos taurus (Bovine) TR38375_c0_g1_i2 Q91W86 VPS11_MOUSE 7.00E-178 GO:0005884; GO:0005769; GO:0030139; GO:0006886; GO:0031902; GO:0005765; GO:0000166; GO:0016192; GO:0008270 Q9H9C1 actin filament; early endosome; endocytic vesicle; intracellular protein transport; late endosome membrane; lysosomal membrane; nucleotide binding; vesicle-mediated transport; zinc ion binding IPR016024; IPR000547; IPR016528; IPR024763; IPR015943; IPR017986; IPR001841; IPR013083; Vacuolar protein sorting-associated protein 11 homolog Vps11 Mus musculus (Mouse) TR38375_c0_g2_i1 Q9H270 VPS11_HUMAN 3.00E-174 GO:0030897; GO:0030139; GO:0005768; GO:0006886; GO:0031902; GO:0005765; GO:0000166; GO:0016192; GO:0008270 P35226 HOPS complex; endocytic vesicle; endosome; intracellular protein transport; late endosome membrane; lysosomal membrane; nucleotide binding; vesicle-mediated transport; zinc ion binding IPR016024; IPR000547; IPR016528; IPR024763; IPR015943; IPR017986; IPR001841; IPR013083; Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108) VPS11 RNF108 PP3476 Homo sapiens (Human) TR38375_c0_g2_i3 Q54YP4 VPS11_DICDI 2.00E-122 GO:0030897; GO:0006886; GO:0042144; GO:0016192; GO:0008270 "HOPS complex; intracellular protein transport; vacuole fusion, non-autophagic; vesicle-mediated transport; zinc ion binding" IPR016024; IPR000547; IPR016528; IPR024763; IPR015943; IPR017986; IPR001841; IPR013083; Vacuolar protein sorting-associated protein 11 homolog vps11 pep5 DDB_G0278141 Dictyostelium discoideum (Slime mold) TR38377_c6_g1_i1 Q5U2Z5 MTR1_RAT 1.00E-128 GO:0006370; GO:0097309; GO:0005737; GO:0004483; GO:0003676; GO:0005634 7-methylguanosine mRNA capping; cap1 mRNA methylation; cytoplasm; mRNA (nucleoside-2'-O-)-methyltransferase activity; nucleic acid binding; nucleus IPR025816; IPR000467; IPR002877; IPR001202; Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (FtsJ methyltransferase domain-containing protein 2) Cmtr1 Ftsjd2 Rattus norvegicus (Rat) TR38377_c6_g1_i2 Q4Q089 MTR1_LEIMA 1.00E-27 GO:0006370; GO:0097309; GO:0004483; GO:0005634 7-methylguanosine mRNA capping; cap1 mRNA methylation; mRNA (nucleoside-2'-O-)-methyltransferase activity; nucleus IPR002877; Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap1 2'O-ribose methyltransferase 1) (MTr1) LmjF36.6660 LmjF_36_6660 Leishmania major TR38377_c7_g2_i1 Q9N1R6 BAT1_RABIT 4.00E-115 GO:0016021; GO:0015175; GO:0042605 integral to membrane; neutral amino acid transmembrane transporter activity; peptide antigen binding IPR002293; "B(0,+)-type amino acid transporter 1 (B(0,+)AT) (4F2-LC6) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)" SLC7A9 BAT1 Oryctolagus cuniculus (Rabbit) TR38377_c7_g2_i10 Q8MH63 LAT1N_HUMAN 2.00E-33 GO:0015171; GO:0016021 amino acid transmembrane transporter activity; integral to membrane IPR002293; Putative L-type amino acid transporter 1-like protein MLAS (hLAT1 3-transmembrane protein MLAS) (hLAT1 3TM MLAS) SLC7A5P1 MLAS Homo sapiens (Human) TR38377_c7_g2_i5 P38734 MUP3_YEAST 4.00E-08 GO:0015191; GO:0016021; GO:0044690 L-methionine transmembrane transporter activity; integral to membrane; methionine import IPR002293; Low-affinity methionine permease MUP3 YHL036W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR38377_c7_g2_i8 Q9N1R6 BAT1_RABIT 3.00E-125 GO:0016021; GO:0015175; GO:0042605 integral to membrane; neutral amino acid transmembrane transporter activity; peptide antigen binding IPR002293; "B(0,+)-type amino acid transporter 1 (B(0,+)AT) (4F2-LC6) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)" SLC7A9 BAT1 Oryctolagus cuniculus (Rabbit) TR38378_c4_g1_i2 Q6PBN5 AUP1_DANRE 4.00E-72 GO:0005789; GO:0016021; GO:0016746 "endoplasmic reticulum membrane; integral to membrane; transferase activity, transferring acyl groups" IPR003892; IPR002123; Ancient ubiquitous protein 1 aup1 Danio rerio (Zebrafish) (Brachydanio rerio) TR38379_c3_g1_i3 Q460N5 PAR14_HUMAN 8.00E-65 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR38379_c3_g2_i1 Q9WYX8 Y508_THEMA 8.00E-22 GO:0005524; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0009378 ATP binding; DNA binding; DNA recombination; DNA repair; DNA replication; four-way junction helicase activity IPR003593; IPR008824; IPR008921; IPR002589; IPR021886; IPR027417; Uncharacterized protein TM_0508 TM_0508 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR38379_c4_g1_i1 Q460N3 PAR15_HUMAN 2.00E-09 GO:0003950; GO:0005634; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) TR38383_c5_g1_i1 Q7SYH5 SC5A8_XENLA 6.00E-91 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR001734; IPR019900; Sodium-coupled monocarboxylate transporter 1 (Electrogenic sodium monocarboxylate cotransporter) (xSMCTe) (Sodium solute transporter Vito) (Solute carrier family 5 member 8) slc5a8 smcte vito Xenopus laevis (African clawed frog) TR38383_c5_g1_i2 Q7SYH5 SC5A8_XENLA 5.00E-93 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR001734; IPR019900; Sodium-coupled monocarboxylate transporter 1 (Electrogenic sodium monocarboxylate cotransporter) (xSMCTe) (Sodium solute transporter Vito) (Solute carrier family 5 member 8) slc5a8 smcte vito Xenopus laevis (African clawed frog) TR38384_c1_g1_i1 Q9Y263 PLAP_HUMAN 0 GO:0070062; GO:0006954; GO:0016005; GO:0006644; GO:0007165 Q76353 extracellular vesicular exosome; inflammatory response; phospholipase A2 activator activity; phospholipid metabolic process; signal transduction IPR016024; IPR015155; IPR013535; IPR015943; IPR001680; IPR017986; Phospholipase A-2-activating protein (PLA2P) (PLAP) PLAA PLAP Homo sapiens (Human) TR38386_c1_g1_i1 P93732 PIP_ARATH 5.00E-135 GO:0004177; GO:0009507; GO:0005829; GO:0006508 aminopeptidase activity; chloroplast; cytosol; proteolysis IPR000073; IPR002410; IPR005944; Proline iminopeptidase (PIP) (EC 3.4.11.5) (Prolyl aminopeptidase) (PAP) PIP At2g14260 T1O16.15 Arabidopsis thaliana (Mouse-ear cress) TR38388_c0_g2_i1 Q7Z3G6 PRIC2_HUMAN 5.00E-163 GO:0016327; GO:0005737; GO:0045197; GO:0016328; GO:0031175; GO:0031965; GO:0008270 apicolateral plasma membrane; cytoplasm; establishment or maintenance of epithelial cell apical/basal polarity; lateral plasma membrane; neuron projection development; nuclear membrane; zinc ion binding IPR010442; IPR001781; Prickle-like protein 2 PRICKLE2 Homo sapiens (Human) TR38389_c3_g1_i1 Q9NVN8 GNL3L_HUMAN 2.00E-121 GO:0005525; GO:0003924; GO:0005739; GO:0005730; GO:0042254 Q00987 GTP binding; GTPase activity; mitochondrion; nucleolus; ribosome biogenesis IPR006073; IPR027417; Guanine nucleotide-binding protein-like 3-like protein GNL3L Homo sapiens (Human) TR38389_c3_g2_i1 Q21086 GNL3_CAEEL 1.00E-122 GO:0005525; GO:0003924; GO:0007281; GO:0002119; GO:0005730; GO:0005654; GO:0042127; GO:0040014; GO:0042254 GTP binding; GTPase activity; germ cell development; nematode larval development; nucleolus; nucleoplasm; regulation of cell proliferation; regulation of multicellular organism growth; ribosome biogenesis IPR000795; IPR014813; IPR023179; IPR006073; IPR027417; Guanine nucleotide-binding protein-like 3 homolog (Nucleostemin-1) nst-1 K01C8.9 Caenorhabditis elegans TR38391_c1_g1_i1 Q3UTY6 THSD4_MOUSE 1.00E-83 GO:0048251; GO:0004222; GO:0001527 elastic fiber assembly; metalloendopeptidase activity; microfibril IPR010294; IPR010909; IPR000884; Thrombospondin type-1 domain-containing protein 4 (A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6) (ADAMTS-like protein 6) (ADAMTSL-6) (ADAMTS-like protein 4) (ADAMTSL-4) Thsd4 Mus musculus (Mouse) TR38392_c0_g1_i1 P54198 HIRA_HUMAN 9.00E-63 GO:0016605; GO:0009653; GO:0003682; GO:0016568; GO:0007369; GO:0042692; GO:0000790; GO:0005634; GO:0001649; GO:0006357; GO:0003700; GO:0003714; GO:0006351 "PML body; anatomical structure morphogenesis; chromatin binding; chromatin modification; gastrulation; muscle cell differentiation; nuclear chromatin; nucleus; osteoblast differentiation; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription corepressor activity; transcription, DNA-dependent" IPR011494; IPR019015; IPR015943; IPR001680; IPR019775; IPR017986; Protein HIRA (TUP1-like enhancer of split protein 1) HIRA DGCR1 HIR TUPLE1 Homo sapiens (Human) TR38392_c1_g1_i1 Q5AGM0 HIR2_CANAL 9.00E-10 GO:0003682; GO:0016568; GO:0005634; GO:0006355; GO:0006351 "chromatin binding; chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011494; IPR019015; IPR015943; IPR001680; IPR019775; IPR017986; Protein HIR2 HIR2 CaO19.11771 CaO19.4295 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) TR38392_c2_g1_i1 P79987 HIRA_CHICK 4.00E-64 GO:0003682; GO:0016568; GO:0005634; GO:0006355; GO:0006351 Q3C1E9 "chromatin binding; chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011494; IPR019015; IPR015943; IPR001680; IPR019775; IPR017986; Protein HIRA (cHIRA) (TUP1-like enhancer of split protein 1) HIRA TUPLE1 Gallus gallus (Chicken) TR38392_c3_g1_i1 P17972 KCNAW_DROME 2.00E-80 GO:0005251; GO:0051260; GO:0030431; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; sleep; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR015572; IPR003131; IPR028325; Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) TR38392_c3_g1_i2 Q63734 KCNC4_RAT 1.00E-78 GO:0051260; GO:0005249; GO:0008076 protein homooligomerization; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR005405; IPR021105; IPR003131; IPR028325; Potassium voltage-gated channel subfamily C member 4 (Raw3) (Voltage-gated potassium channel subunit Kv3.4) Kcnc4 Rattus norvegicus (Rat) TR38393_c3_g3_i1 Q8JHV9 BIR7A_XENLA 3.00E-27 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR38393_c3_g3_i2 Q8JHV9 BIR7A_XENLA 3.00E-27 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR38394_c0_g2_i2 Q9WYX8 Y508_THEMA 9.00E-35 GO:0005524; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0009378 ATP binding; DNA binding; DNA recombination; DNA repair; DNA replication; four-way junction helicase activity IPR003593; IPR008824; IPR008921; IPR002589; IPR021886; IPR027417; Uncharacterized protein TM_0508 TM_0508 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR38394_c0_g2_i3 Q2EMV9 PAR14_MOUSE 3.00E-45 GO:0003950; GO:0005737; GO:0003676; GO:0005634; GO:0005886; GO:0006355; GO:0006351 P06745 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleic acid binding; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR000504; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) TR38394_c0_g2_i4 Q460N5 PAR14_HUMAN 2.00E-52 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR38394_c0_g2_i6 B7LT90 YMDB_ESCF3 1.00E-14 GO:0019213; GO:0060701; GO:0001883; GO:0042278; GO:0008428 deacetylase activity; negative regulation of ribonuclease activity; purine nucleoside binding; purine nucleoside metabolic process; ribonuclease inhibitor activity IPR002589; IPR024900; O-acetyl-ADP-ribose deacetylase (EC 3.5.1.-) (Regulator of RNase III activity) ymdB EFER_1884 Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73) TR38394_c0_g2_i7 Q460N5 PAR14_HUMAN 1.00E-21 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR38395_c3_g1_i3 F6UA42 UHRF1_XENTR 2.00E-48 GO:0007049; GO:0000791; GO:0044729; GO:0000792; GO:0016574; GO:0010216; GO:0035064; GO:0000122; GO:0000790; GO:0051865; GO:0042787; GO:0005657; GO:0006351; GO:0004842; GO:0008270 "cell cycle; euchromatin; hemi-methylated DNA-binding; heterochromatin; histone ubiquitination; maintenance of DNA methylation; methylated histone residue binding; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; protein autoubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; replication fork; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR021991; IPR015947; IPR014722; IPR003105; IPR000626; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UHRF1 (EC 6.3.2.-) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) uhrf1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38395_c3_g1_i4 A7E320 UHRF1_BOVIN 1.00E-45 GO:0006281; GO:0007049; GO:0000791; GO:0044729; GO:0000792; GO:0010390; GO:0016574; GO:0010216; GO:0035064; GO:0000122; GO:0000790; GO:0016363; GO:0051865; GO:0042787; GO:0005657; GO:0006351; GO:0004842; GO:0008270 "DNA repair; cell cycle; euchromatin; hemi-methylated DNA-binding; heterochromatin; histone monoubiquitination; histone ubiquitination; maintenance of DNA methylation; methylated histone residue binding; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; nuclear matrix; protein autoubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; replication fork; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR021991; IPR015947; IPR014722; IPR003105; IPR000626; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UHRF1 (EC 6.3.2.-) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) UHRF1 Bos taurus (Bovine) TR38395_c3_g1_i5 F6UA42 UHRF1_XENTR 4.00E-49 GO:0007049; GO:0000791; GO:0044729; GO:0000792; GO:0016574; GO:0010216; GO:0035064; GO:0000122; GO:0000790; GO:0051865; GO:0042787; GO:0005657; GO:0006351; GO:0004842; GO:0008270 "cell cycle; euchromatin; hemi-methylated DNA-binding; heterochromatin; histone ubiquitination; maintenance of DNA methylation; methylated histone residue binding; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; protein autoubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; replication fork; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR021991; IPR015947; IPR014722; IPR003105; IPR000626; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UHRF1 (EC 6.3.2.-) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) uhrf1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38396_c1_g1_i1 Q8K0U4 HS12A_MOUSE 6.00E-58 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR38396_c1_g1_i2 Q00488 DNAK_MYCPA 9.00E-09 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (70 kDa antigen) (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK MAP_3840 Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) TR38402_c1_g1_i1 Q4UMH6 Y381_RICFE 7.00E-28 GO:0015969 guanosine tetraphosphate metabolic process IPR002110; IPR020683; IPR007685; Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR38402_c1_g2_i1 O75179 ANR17_HUMAN 2.00E-31 GO:0003723; GO:0001955; GO:0005737; GO:0019048; GO:0051151; GO:0005634 RNA binding; blood vessel maturation; cytoplasm; modulation by virus of host morphology or physiology; negative regulation of smooth muscle cell differentiation; nucleus IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) TR38404_c1_g1_i1 Q28DX0 QTRD1_XENTR 1.00E-123 GO:0046872; GO:0005739; GO:0008479; GO:0008616 metal ion binding; mitochondrion; queuine tRNA-ribosyltransferase activity; queuosine biosynthetic process IPR002616; tRNA modification; tRNA-queuosine biosynthesis. Queuine tRNA-ribosyltransferase subunit qtrtd1 (EC 2.4.2.29) (Queuine tRNA-ribosyltransferase domain-containing protein 1) qtrtd1 TEgg038e14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38404_c1_g1_i2 A8WJ41 QTRD1_CAEBR 6.00E-58 GO:0046872; GO:0008479; GO:0008616 metal ion binding; queuine tRNA-ribosyltransferase activity; queuosine biosynthetic process IPR002616; tRNA modification; tRNA-queuosine biosynthesis. Queuine tRNA-ribosyltransferase subunit tgt-2 (EC 2.4.2.29) (tRNA-guanine transglycosylase subunit tgt-2) tgt-2 CBG23704 Caenorhabditis briggsae TR38405_c3_g1_i1 Q9M390 PTR1_ARATH 2.00E-27 GO:0042936; GO:0016021; GO:0006807; GO:0005886; GO:0009506; GO:0015031; GO:0042937 dipeptide transporter activity; integral to membrane; nitrogen compound metabolic process; plasma membrane; plasmodesma; protein transport; tripeptide transporter activity IPR016196; IPR000109; IPR018456; Peptide transporter PTR1 PTR1 At3g54140 F24B22.100 Arabidopsis thaliana (Mouse-ear cress) TR38405_c3_g1_i10 Q9P380 PTR2_SCHPO 1.00E-26 GO:0032153; GO:0071916; GO:0000324; GO:0005887; GO:0031520; GO:0015031; GO:0035443; GO:0042937 cell division site; dipeptide transmembrane transporter activity; fungal-type vacuole; integral to plasma membrane; plasma membrane of cell tip; protein transport; tripeptide transmembrane transport; tripeptide transporter activity IPR016196; IPR000109; IPR018456; Probable peptide transporter ptr2 (Peptide permease ptr2) ptr2 SPBC13A2.04c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38405_c3_g1_i3 Q21219 PEPT1_CAEEL 1.00E-07 GO:0016324; GO:0008340; GO:0042936; GO:0016021; GO:0019915; GO:2000192; GO:0002119; GO:0040010; GO:0040018; GO:0015031; GO:0006885; GO:0000003; GO:0009408; GO:0006979 apical plasma membrane; determination of adult lifespan; dipeptide transporter activity; integral to membrane; lipid storage; negative regulation of fatty acid transport; nematode larval development; positive regulation of growth rate; positive regulation of multicellular organism growth; protein transport; regulation of pH; reproduction; response to heat; response to oxidative stress IPR016196; IPR004768; IPR000109; IPR018456; Peptide transporter family 1 (Di-/tri-peptide transporter CPTB) (Oligopeptide transporter 1) pept-1 cptb pep-2 K04E7.2 Caenorhabditis elegans TR38405_c3_g1_i4 Q68F72 S15A4_XENLA 7.00E-59 GO:0016021; GO:0006857; GO:0015031; GO:0015293 integral to membrane; oligopeptide transport; protein transport; symporter activity IPR016196; IPR000109; IPR018456; Solute carrier family 15 member 4 (Peptide transporter 4) slc15a4 Xenopus laevis (African clawed frog) TR38405_c3_g1_i7 Q9LYD5 PTR48_ARATH 1.00E-20 GO:0016021; GO:0005215 integral to membrane; transporter activity IPR016196; IPR000109; Putative peptide/nitrate transporter At5g11570 At5g11570 F15N18.160 Arabidopsis thaliana (Mouse-ear cress) TR38405_c3_g1_i9 O09014 S15A4_RAT 2.00E-55 GO:0005290; GO:0016021; GO:0006857; GO:0015031; GO:0015293 L-histidine transmembrane transporter activity; integral to membrane; oligopeptide transport; protein transport; symporter activity IPR016196; IPR000109; IPR018456; Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (rPHT1) Slc15a4 Pht1 Rattus norvegicus (Rat) TR38406_c2_g4_i2 P25162 ACH4_DROME 2.00E-141 GO:0004889; GO:0005892; GO:0030054; GO:0045211; GO:0017085; GO:0007271 "acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; postsynaptic membrane; response to insecticide; synaptic transmission, cholinergic" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit beta-like 2 nAcRbeta-96A Acr96Ac AcrF SBD CG6798 Drosophila melanogaster (Fruit fly) TR38406_c2_g6_i1 Q91WN3 S7A13_MOUSE 2.00E-38 GO:0015171; GO:0016021 amino acid transmembrane transporter activity; integral to membrane IPR002293; Solute carrier family 7 member 13 (Sodium-independent aspartate/glutamate transporter 1) (X-amino acid transporter 2) Slc7a13 Agt1 Xat2 Mus musculus (Mouse) TR38406_c2_g6_i3 P82251 BAT1_HUMAN 2.00E-95 GO:0015184; GO:0007596; GO:0006520; GO:0005887; GO:0050900; GO:0015175; GO:0042605; GO:0006461 L-cystine transmembrane transporter activity; blood coagulation; cellular amino acid metabolic process; integral to plasma membrane; leukocyte migration; neutral amino acid transmembrane transporter activity; peptide antigen binding; protein complex assembly IPR002293; "B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)" SLC7A9 BAT1 Homo sapiens (Human) TR38406_c2_g6_i4 Q9GIP4 LAT1L_HUMAN 8.00E-17 GO:0015171; GO:0016021 amino acid transmembrane transporter activity; integral to membrane IPR002293; Putative L-type amino acid transporter 1-like protein IMAA (hLAT1 3-transmembrane protein IMAA) (hLAT1 3TM IMAA) (hLAT1 3-transmembrane protein MMAA) (hLAT1 3TM MMAA) SLC7A5P2 IMAA MMAA Homo sapiens (Human) TR38406_c2_g6_i5 P45539 FRLA_ECOLI 2.00E-09 GO:0015171; GO:0030393; GO:0016021; GO:0005886 amino acid transmembrane transporter activity; fructoselysine metabolic process; integral to membrane; plasma membrane IPR002293; Carbohydrate metabolism; fructoselysine degradation. Putative fructoselysine transporter FrlA frlA yhfM b3370 JW3333 Escherichia coli (strain K12) TR38407_c0_g1_i2 Q9NW68 BSDC1_HUMAN 2.00E-46 IPR005607; BSD domain-containing protein 1 BSDC1 UNQ2494/PRO5781 Homo sapiens (Human) TR38408_c0_g2_i1 P25324 THTR_CHICK 8.00E-62 GO:0008097; GO:0005759; GO:0035928; GO:0004792 5S rRNA binding; mitochondrial matrix; rRNA import into mitochondrion; thiosulfate sulfurtransferase activity IPR001763; IPR001307; Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese) TST Gallus gallus (Chicken) TR38409_c0_g1_i2 Q9FR37 AMI1_ARATH 2.00E-10 GO:0004040; GO:0016884; GO:0005829; GO:0043864; GO:0009684 "amidase activity; carbon-nitrogen ligase activity, with glutamine as amido-N-donor; cytosol; indoleacetamide hydrolase activity; indoleacetic acid biosynthetic process" IPR000120; IPR020556; IPR023631; Amidase 1 (AtAMI1) (EC 3.5.1.4) (Translocon at the outer membrane of chloroplasts 64-I) (AtTOC64-I) AMI1 TOC64-I At1g08980 F7G19.15 Arabidopsis thaliana (Mouse-ear cress) TR38409_c0_g1_i3 Q0VFI5 GATA_XENTR 6.00E-172 GO:0005524; GO:0016884; GO:0005739; GO:0006412 "ATP binding; carbon-nitrogen ligase activity, with glutamine as amido-N-donor; mitochondrion; translation" IPR000120; IPR023631; IPR004412; "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (Glu-AdT subunit A) (EC 6.3.5.-) (Glutaminyl-tRNA synthase-like protein 1)" qrsl1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38409_c0_g1_i4 Q8AVG9 GATA_XENLA 4.00E-174 GO:0005524; GO:0016884; GO:0005739; GO:0006412 "ATP binding; carbon-nitrogen ligase activity, with glutamine as amido-N-donor; mitochondrion; translation" IPR000120; IPR023631; IPR004412; "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (Glu-AdT subunit A) (EC 6.3.5.-) (Glutaminyl-tRNA synthase-like protein 1)" qrsl1 Xenopus laevis (African clawed frog) TR38409_c0_g1_i5 Q8AVG9 GATA_XENLA 8.00E-169 GO:0005524; GO:0016884; GO:0005739; GO:0006412 "ATP binding; carbon-nitrogen ligase activity, with glutamine as amido-N-donor; mitochondrion; translation" IPR000120; IPR023631; IPR004412; "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (Glu-AdT subunit A) (EC 6.3.5.-) (Glutaminyl-tRNA synthase-like protein 1)" qrsl1 Xenopus laevis (African clawed frog) TR38409_c0_g2_i1 O28325 Y1954_ARCFU 4.00E-14 GO:0004040; GO:0016884 "amidase activity; carbon-nitrogen ligase activity, with glutamine as amido-N-donor" IPR000120; IPR020556; IPR023631; Putative amidase AF_1954 (EC 3.5.1.4) AF_1954 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) TR38410_c3_g3_i1 Q80V42 CBPM_MOUSE 2.00E-114 GO:0031225; GO:0004181; GO:0005886; GO:0006508; GO:0008270 anchored to membrane; metallocarboxypeptidase activity; plasma membrane; proteolysis; zinc ion binding IPR008969; IPR014766; IPR027062; IPR000834; Carboxypeptidase M (CPM) (EC 3.4.17.12) Cpm Mus musculus (Mouse) TR38410_c3_g3_i3 Q80V42 CBPM_MOUSE 6.00E-114 GO:0031225; GO:0004181; GO:0005886; GO:0006508; GO:0008270 anchored to membrane; metallocarboxypeptidase activity; plasma membrane; proteolysis; zinc ion binding IPR008969; IPR014766; IPR027062; IPR000834; Carboxypeptidase M (CPM) (EC 3.4.17.12) Cpm Mus musculus (Mouse) TR38411_c1_g1_i2 Q16667 CDKN3_HUMAN 2.00E-60 GO:0000082; GO:0007050; GO:0008285; GO:0048471; GO:0004722; GO:0004725; GO:0008138; GO:0000079 P24941 G1/S transition of mitotic cell cycle; cell cycle arrest; negative regulation of cell proliferation; perinuclear region of cytoplasm; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; regulation of cyclin-dependent protein serine/threonine kinase activity IPR008425; IPR022778; IPR000387; Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Cyclin-dependent kinase interactor 1) (Cyclin-dependent kinase-interacting protein 2) (Kinase-associated phosphatase) CDKN3 CDI1 CIP2 KAP Homo sapiens (Human) TR38414_c0_g2_i5 P45469 YRAR_ECOLI 2.00E-24 IPR016040 Uncharacterized protein YraR yraR b3152 JW5528 Escherichia coli (strain K12) TR38414_c0_g2_i6 Q9Z2G9 HTAI2_MOUSE 6.00E-46 GO:0001525; GO:0006915; GO:0030154; GO:0005737; GO:0005635; GO:0051170; GO:0016491; GO:0045765 angiogenesis; apoptotic process; cell differentiation; cytoplasm; nuclear envelope; nuclear import; oxidoreductase activity; regulation of angiogenesis IPR016040 Oxidoreductase HTATIP2 (EC 1.1.1.-) Htatip2 Cc3 Tip30 Mus musculus (Mouse) TR38414_c0_g3_i1 Q6FRC1 FMP52_CANGA 4.00E-15 GO:0005741 mitochondrial outer membrane IPR016040 "Protein FMP52, mitochondrial" FMP52 CAGL0H09768g Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) TR38414_c0_g3_i2 Q5AP65 FMP52_CANAL 6.00E-18 GO:0005741 mitochondrial outer membrane IPR016040 "Protein FMP52, mitochondrial" FMP52 CaO19.12363 CaO19.4898 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) TR38414_c0_g3_i3 Q9Z2G9 HTAI2_MOUSE 1.00E-42 GO:0001525; GO:0006915; GO:0030154; GO:0005737; GO:0005635; GO:0051170; GO:0016491; GO:0045765 angiogenesis; apoptotic process; cell differentiation; cytoplasm; nuclear envelope; nuclear import; oxidoreductase activity; regulation of angiogenesis IPR016040 Oxidoreductase HTATIP2 (EC 1.1.1.-) Htatip2 Cc3 Tip30 Mus musculus (Mouse) TR38419_c1_g5_i2 Q07553 GCY3E_DROME 8.00E-61 GO:0005524; GO:0005525; GO:0004383; GO:0005887; GO:0035556; GO:0004872; GO:0016772 "ATP binding; GTP binding; guanylate cyclase activity; integral to plasma membrane; intracellular signal transduction; receptor activity; transferase activity, transferring phosphorus-containing groups" IPR001054; IPR018297; IPR001828; IPR011009; IPR028082; IPR000719; IPR001245; Guanylate cyclase 32E (EC 4.6.1.2) Gyc32E GC CG33114 Drosophila melanogaster (Fruit fly) TR3842_c0_g1_i1 O18023 YPG43_CAEEL 6.00E-08 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR006150; IPR002602; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR028150; Ig-like and fibronectin type-III domain-containing protein C25G4.10 C25G4.10 Caenorhabditis elegans TR38420_c1_g1_i10 Q9VGY5 MET15_DROME 8.00E-92 GO:0008168 methyltransferase activity IPR002903; IPR023397; Probable methyltransferase-like protein 15 homolog (EC 2.1.1.-) CG14683 Drosophila melanogaster (Fruit fly) TR38420_c1_g1_i11 Q9DCL4 MET15_MOUSE 2.00E-87 GO:0008168 methyltransferase activity IPR002903; IPR023397; Probable methyltransferase-like protein 15 (EC 2.1.1.-) (Methyltransferase 5 domain-containing protein 1) Mettl15 Mett5d1 Mus musculus (Mouse) TR38420_c1_g1_i4 Q9DCL4 MET15_MOUSE 2.00E-92 GO:0008168 methyltransferase activity IPR002903; IPR023397; Probable methyltransferase-like protein 15 (EC 2.1.1.-) (Methyltransferase 5 domain-containing protein 1) Mettl15 Mett5d1 Mus musculus (Mouse) TR38420_c1_g1_i6 Q2GGS8 RSMH_EHRCR 1.00E-56 GO:0005737; GO:0071424; GO:0070475 cytoplasm; rRNA (cytosine-N4-)-methyltransferase activity; rRNA base methylation IPR002903; IPR023397; Ribosomal RNA small subunit methyltransferase H (EC 2.1.1.199) (16S rRNA m(4)C1402 methyltransferase) (rRNA (cytosine-N(4)-)-methyltransferase RsmH) rsmH mraW ECH_0542 Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas) TR38421_c0_g2_i1 Q9SFB8 PI5K6_ARATH 2.00E-22 GO:0016308; GO:0005524; GO:0016324; GO:0072583; GO:0090406 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding; apical plasma membrane; clathrin-mediated endocytosis; pollen tube IPR003409; IPR017163; IPR023610; IPR027483; IPR002498; IPR027484; IPR016034; Phosphatidylinositol 4-phosphate 5-kinase 6 (AtPIP5K6) (EC 2.7.1.68) (1-phosphatidylinositol 4-phosphate kinase 6) (Diphosphoinositide kinase 6) (PtdIns(4)P-5-kinase 6) PIP5K6 At3g07960 F17A17.30 Arabidopsis thaliana (Mouse-ear cress) TR38421_c0_g2_i2 B2RC85 R10B2_HUMAN 2.00E-177 IPR003409; Radial spoke head 10 homolog B2 RSPH10B2 Homo sapiens (Human) TR38421_c0_g2_i3 B2RC85 R10B2_HUMAN 1.00E-43 IPR003409; Radial spoke head 10 homolog B2 RSPH10B2 Homo sapiens (Human) TR38423_c1_g1_i1 Q02225 SKI_XENLA 7.00E-86 GO:0000166; GO:0005634 nucleotide binding; nucleus IPR014890; IPR009061; IPR010919; IPR003380; IPR023216; Ski oncogene (Proto-oncogene c-Ski) ski Xenopus laevis (African clawed frog) TR38423_c1_g1_i3 Q02225 SKI_XENLA 7.00E-86 GO:0000166; GO:0005634 nucleotide binding; nucleus IPR014890; IPR009061; IPR010919; IPR003380; IPR023216; Ski oncogene (Proto-oncogene c-Ski) ski Xenopus laevis (African clawed frog) TR38423_c1_g1_i7 Q02225 SKI_XENLA 7.00E-86 GO:0000166; GO:0005634 nucleotide binding; nucleus IPR014890; IPR009061; IPR010919; IPR003380; IPR023216; Ski oncogene (Proto-oncogene c-Ski) ski Xenopus laevis (African clawed frog) TR38423_c1_g1_i8 Q02225 SKI_XENLA 7.00E-86 GO:0000166; GO:0005634 nucleotide binding; nucleus IPR014890; IPR009061; IPR010919; IPR003380; IPR023216; Ski oncogene (Proto-oncogene c-Ski) ski Xenopus laevis (African clawed frog) TR38423_c1_g1_i9 P17863 SKI_AVIES 7.00E-85 GO:0000166; GO:0005634 Q13573 nucleotide binding; nucleus IPR014890; IPR009061; IPR010919; IPR003380; IPR023216; Transforming protein Ski V-SKI Avian erythroblastosis virus (strain Sloan-Kettering) TR38427_c0_g1_i5 Q567Z6 CRIPT_DANRE 3.00E-49 GO:0005737 cytoplasm IPR019367; Cysteine-rich PDZ-binding protein (Cysteine-rich interactor of PDZ three) (Cysteine-rich interactor of PDZ3) cript zgc:110618 Danio rerio (Zebrafish) (Brachydanio rerio) TR38428_c2_g2_i2 Q6P6X9 NUP53_DANRE 3.00E-70 GO:0051028; GO:0031965; GO:0005643; GO:0015031; GO:0055085 mRNA transport; nuclear membrane; nuclear pore; protein transport; transmembrane transport IPR017389; IPR007846; Nucleoporin NUP53 (35 kDa nucleoporin) (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) nup35 nup53 zgc:65979 Danio rerio (Zebrafish) (Brachydanio rerio) TR38429_c2_g1_i4 Q80Z96 VANG1_MOUSE 6.00E-100 GO:0016021; GO:0007275 P31016; P51141; Q60838; Q61062 integral to membrane; multicellular organismal development IPR009539; Vang-like protein 1 (Loop-tail protein 2) (Van Gogh-like protein 1) Vangl1 Lpp2 Mus musculus (Mouse) TR38429_c3_g2_i1 Q16U25 FAM50_AEDAE 2.00E-137 GO:0005634 nucleus IPR007005; Protein FAM50 homolog AAEL010045 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR38429_c3_g2_i2 Q9VAY7 FAM50_DROME 1.00E-139 GO:0022008; GO:0005634 neurogenesis; nucleus IPR007005; Protein FAM50 homolog CG12259 Drosophila melanogaster (Fruit fly) TR38430_c1_g1_i1 Q9ULV1 FZD4_HUMAN 0 GO:0004930; GO:0030165; GO:0007223; GO:0042813; GO:0017147; GO:0007420; GO:0060070; GO:0042995; GO:0009986; GO:0005911; GO:0071300; GO:0061301; GO:0005737; GO:0009790; GO:0035426; GO:0005887; GO:0031987; GO:0010812; GO:0030182; GO:0043507; GO:0051091; GO:0045893; GO:0042701; GO:0030947; GO:0061299; GO:0061304; GO:0007605; GO:0034446; GO:0001570 G3GTH2 "G-protein coupled receptor activity; PDZ domain binding; Wnt receptor signaling pathway, calcium modulating pathway; Wnt-activated receptor activity; Wnt-protein binding; brain development; canonical Wnt receptor signaling pathway; cell projection; cell surface; cell-cell junction; cellular response to retinoic acid; cerebellum vasculature morphogenesis; cytoplasm; embryo development; extracellular matrix-cell signaling; integral to plasma membrane; locomotion involved in locomotory behavior; negative regulation of cell-substrate adhesion; neuron differentiation; positive regulation of JUN kinase activity; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; progesterone secretion; regulation of vascular endothelial growth factor receptor signaling pathway; retina vasculature morphogenesis in camera-type eye; retinal blood vessel morphogenesis; sensory perception of sound; substrate adhesion-dependent cell spreading; vasculogenesis" IPR000539; IPR015526; IPR020067; IPR026551; IPR017981; Frizzled-4 (Fz-4) (hFz4) (FzE4) (CD antigen CD344) FZD4 Homo sapiens (Human) TR38431_c4_g1_i1 P70501 RBM10_RAT 8.00E-70 GO:0070935; GO:0003723; GO:0008285; GO:0000122; GO:0000166; GO:0005634; GO:0034393; GO:0008270 3'-UTR-mediated mRNA stabilization; RNA binding; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; nucleotide binding; nucleus; positive regulation of smooth muscle cell apoptotic process; zinc ion binding IPR000467; IPR012677; IPR000504; IPR007087; IPR015880; IPR001876; RNA-binding protein 10 (RNA-binding motif protein 10) (RNA-binding protein S1-1) Rbm10 Rattus norvegicus (Rat) TR38431_c4_g1_i10 P70501 RBM10_RAT 5.00E-70 GO:0070935; GO:0003723; GO:0008285; GO:0000122; GO:0000166; GO:0005634; GO:0034393; GO:0008270 3'-UTR-mediated mRNA stabilization; RNA binding; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; nucleotide binding; nucleus; positive regulation of smooth muscle cell apoptotic process; zinc ion binding IPR000467; IPR012677; IPR000504; IPR007087; IPR015880; IPR001876; RNA-binding protein 10 (RNA-binding motif protein 10) (RNA-binding protein S1-1) Rbm10 Rattus norvegicus (Rat) TR38431_c4_g1_i2 P70501 RBM10_RAT 1.00E-70 GO:0070935; GO:0003723; GO:0008285; GO:0000122; GO:0000166; GO:0005634; GO:0034393; GO:0008270 3'-UTR-mediated mRNA stabilization; RNA binding; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; nucleotide binding; nucleus; positive regulation of smooth muscle cell apoptotic process; zinc ion binding IPR000467; IPR012677; IPR000504; IPR007087; IPR015880; IPR001876; RNA-binding protein 10 (RNA-binding motif protein 10) (RNA-binding protein S1-1) Rbm10 Rattus norvegicus (Rat) TR38431_c4_g1_i8 P87143 YDMD_SCHPO 1.00E-09 GO:0003723; GO:0045292; GO:0000166; GO:0005634; GO:0008270 "RNA binding; mRNA cis splicing, via spliceosome; nucleotide binding; nucleus; zinc ion binding" IPR000467; IPR012677; IPR000504; IPR015880; IPR001876; Uncharacterized RNA-binding protein C57A7.13 SPAC57A7.13 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38433_c0_g1_i1 A7MBF6 CA228_BOVIN 1.00E-161 IPR011989; IPR016024; Uncharacterized protein C1orf228 homolog Bos taurus (Bovine) TR38435_c1_g1_i2 Q9QY36 NAA10_MOUSE 5.00E-96 GO:0008080; GO:0006474; GO:0005737; GO:0005634; GO:0004596; GO:0043022 N-acetyltransferase activity; N-terminal protein amino acid acetylation; cytoplasm; nucleus; peptide alpha-N-acetyltransferase activity; ribosome binding IPR016181; IPR000182; N-alpha-acetyltransferase 10 (EC 2.3.1.-) (EC 2.3.1.88) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (NatA catalytic subunit) Naa10 Ard1 Ard1a Te2 Mus musculus (Mouse) TR38435_c1_g1_i4 Q9QY36 NAA10_MOUSE 4.00E-96 GO:0008080; GO:0006474; GO:0005737; GO:0005634; GO:0004596; GO:0043022 N-acetyltransferase activity; N-terminal protein amino acid acetylation; cytoplasm; nucleus; peptide alpha-N-acetyltransferase activity; ribosome binding IPR016181; IPR000182; N-alpha-acetyltransferase 10 (EC 2.3.1.-) (EC 2.3.1.88) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (NatA catalytic subunit) Naa10 Ard1 Ard1a Te2 Mus musculus (Mouse) TR38436_c1_g1_i1 Q6VN19 RBP10_MOUSE 0 GO:0005087; GO:0048487; GO:0005881; GO:0000226; GO:0005634 Ran guanyl-nucleotide exchange factor activity; beta-tubulin binding; cytoplasmic microtubule; microtubule cytoskeleton organization; nucleus IPR001870; IPR008985; IPR013144; IPR024964; IPR006595; IPR006594; IPR013720; IPR027713; IPR018355; IPR003877; Ran-binding protein 10 (RanBP10) Ranbp10 Kiaa1464 Mus musculus (Mouse) TR38436_c1_g1_i3 P69566 RANB9_MOUSE 0 GO:0008536; GO:0005737; GO:0005634 Q9JI18 Ran GTPase binding; cytoplasm; nucleus IPR001870; IPR008985; IPR013144; IPR024964; IPR006595; IPR006594; IPR013720; IPR027713; IPR018355; IPR003877; Ran-binding protein 9 (RanBP9) (B-cell antigen receptor Ig beta-associated protein 1) (IBAP-1) (Ran-binding protein M) (RanBPM) Ranbp9 Ranbpm Mus musculus (Mouse) TR38437_c2_g3_i2 Q9PQ36 CSD_UREPA 5.00E-16 GO:0031071; GO:0030170 cysteine desulfurase activity; pyridoxal phosphate binding IPR000192; IPR015424; IPR015421; IPR015422; Probable cysteine desulfurase (EC 2.8.1.7) csd UU454 Ureaplasma parvum serovar 3 (strain ATCC 700970) TR38437_c2_g3_i3 Q96I15 SCLY_HUMAN 0 GO:0006520; GO:0005829; GO:0030170; GO:0009000; GO:0016740 cellular amino acid metabolic process; cytosol; pyridoxal phosphate binding; selenocysteine lyase activity; transferase activity IPR000192; IPR016454; IPR015424; IPR015421; IPR015422; Selenocysteine lyase (hSCL) (EC 4.4.1.16) SCLY SCL Homo sapiens (Human) TR38437_c2_g3_i5 Q9KII6 CSD_MYCPA 9.00E-16 GO:0031071; GO:0006534; GO:0030170 cysteine desulfurase activity; cysteine metabolic process; pyridoxal phosphate binding IPR000192; IPR010970; IPR015424; IPR015421; IPR015422; Probable cysteine desulfurase (EC 2.8.1.7) MAP_2120c Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) TR38437_c2_g3_i6 Q9PDA6 CSD_XYLFA 2.00E-12 GO:0031071; GO:0006534; GO:0030170 cysteine desulfurase activity; cysteine metabolic process; pyridoxal phosphate binding IPR000192; IPR020578; IPR010970; IPR015424; IPR015421; IPR015422; Probable cysteine desulfurase (EC 2.8.1.7) csd XF_1473 Xylella fastidiosa (strain 9a5c) TR38437_c2_g3_i7 P12623 NIFS_NOSS1 1.00E-68 GO:0006520; GO:0031071; GO:0009399; GO:0030170 cellular amino acid metabolic process; cysteine desulfurase activity; nitrogen fixation; pyridoxal phosphate binding IPR000192; IPR020578; IPR017772; IPR016454; IPR015424; IPR015421; IPR015422; Cysteine desulfurase (EC 2.8.1.7) (Nitrogenase metalloclusters biosynthesis protein NifS) nifS all1457 Nostoc sp. (strain PCC 7120 / UTEX 2576) TR38443_c4_g1_i1 O15067 PUR4_HUMAN 4.00E-113 GO:0006189; GO:0005524; GO:0005829; GO:0006541; GO:0004642; GO:0006144; GO:0042493 P11171; P30480; P23508; P19532; Q9UBN6; Q9Y4K3; P40337 'de novo' IMP biosynthetic process; ATP binding; cytosol; glutamine metabolic process; phosphoribosylformylglycinamidine synthase activity; purine nucleobase metabolic process; response to drug IPR010918; IPR000728; IPR017926; IPR010073; IPR016188; Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribotide amidotransferase) (FGARAT) (Formylglycinamide ribotide synthetase) PFAS KIAA0361 Homo sapiens (Human) TR38443_c5_g1_i8 P05400 POL_CERV 2.00E-10 GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR000588; IPR000477; Enzymatic polyprotein [Includes: Aspartic protease (EC 3.4.23.-); Endonuclease; Reverse transcriptase (EC 2.7.7.49)] ORF V Carnation etched ring virus (CERV) TR38444_c10_g1_i1 Q9BY12 SCAPE_HUMAN 4.00E-11 GO:0005783; GO:0046872; GO:0005634 endoplasmic reticulum; metal ion binding; nucleus IPR015880; S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291) SCAPER KIAA1454 ZNF291 MSTP063 Homo sapiens (Human) TR38444_c2_g2_i1 Q9BY12 SCAPE_HUMAN 5.00E-27 GO:0005783; GO:0046872; GO:0005634 endoplasmic reticulum; metal ion binding; nucleus IPR015880; S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291) SCAPER KIAA1454 ZNF291 MSTP063 Homo sapiens (Human) TR38444_c8_g1_i1 Q9BY12 SCAPE_HUMAN 2.00E-61 GO:0005783; GO:0046872; GO:0005634 endoplasmic reticulum; metal ion binding; nucleus IPR015880; S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291) SCAPER KIAA1454 ZNF291 MSTP063 Homo sapiens (Human) TR38445_c1_g1_i1 Q99NH0 ANR17_MOUSE 8.00E-08 GO:0003723; GO:0001955; GO:0005737; GO:0007492; GO:0051151; GO:0005634 RNA binding; blood vessel maturation; cytoplasm; endoderm development; negative regulation of smooth muscle cell differentiation; nucleus IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) TR38445_c1_g2_i1 Q6DGX3 ANR54_DANRE 2.00E-09 GO:0005737; GO:0030496; GO:0005634 cytoplasm; midbody; nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 54 ankrd54 zgc:110569 zgc:92735 Danio rerio (Zebrafish) (Brachydanio rerio) TR38445_c1_g3_i1 O90760 V031_FOWPN 1.00E-08 IPR002110; IPR020683; IPR018272; Putative ankyrin repeat protein FPV031 ANK3 FPV031 Fowlpox virus (strain NVSL) (FPV) TR38445_c1_g3_i2 Q9Z2X3 PSD10_RAT 2.00E-07 GO:0006915; GO:0005737; GO:0007253; GO:0043518; GO:0043409; GO:0032088; GO:0043066; GO:0090201; GO:0000122; GO:0005634; GO:0030307; GO:0045737; GO:0032436; GO:0031398; GO:0070682 "apoptotic process; cytoplasm; cytoplasmic sequestering of NF-kappaB; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of MAPK cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of apoptotic process; negative regulation of release of cytochrome c from mitochondria; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of cell growth; positive regulation of cyclin-dependent protein kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; proteasome regulatory particle assembly" IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) Psmd10 Rattus norvegicus (Rat) TR38447_c4_g1_i2 Q7Z0T3 TEMPT_APLCA 2.00E-26 GO:0005576 extracellular region Temptin Aplysia californica (California sea hare) TR38447_c5_g2_i1 Q8R0X2 CACL1_MOUSE 6.00E-65 GO:0000082; GO:0031461; GO:0008284; GO:0045860; GO:0006511 G1/S transition of mitotic cell cycle; cullin-RING ubiquitin ligase complex; positive regulation of cell proliferation; positive regulation of protein kinase activity; ubiquitin-dependent protein catabolic process IPR001373; IPR016159; CDK2-associated and cullin domain-containing protein 1 Cacul1 Mus musculus (Mouse) TR38447_c6_g1_i1 Q9UII4 HERC5_HUMAN 7.00E-11 GO:0042296; GO:0032020; GO:0019221; GO:0005829; GO:0051607; GO:0045087; GO:0032480; GO:0005634; GO:0048471; GO:0042787; GO:0000079; GO:0050688; GO:0004842 ISG15 ligase activity; ISG15-protein conjugation; cytokine-mediated signaling pathway; cytosol; defense response to virus; innate immune response; negative regulation of type I interferon production; nucleus; perinuclear region of cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of defense response to virus; ubiquitin-protein ligase activity IPR000569; IPR009091; IPR000408; E3 ISG15--protein ligase HERC5 (EC 6.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5) HERC5 CEB1 CEBP1 Homo sapiens (Human) TR38447_c6_g1_i2 Q6PAV2 HERC4_MOUSE 2.00E-08 GO:0030154; GO:0005737; GO:0005829; GO:0005634; GO:0042787; GO:0007283; GO:0004842 cell differentiation; cytoplasm; cytosol; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; spermatogenesis; ubiquitin-protein ligase activity IPR000569; IPR009091; IPR000408; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HERC4 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 4) Herc4 Mus musculus (Mouse) TR38447_c6_g1_i3 Q9VR91 HERC2_DROME 1.00E-17 GO:0005814; GO:0005737; GO:0020037; GO:0046872; GO:0005634; GO:0042787; GO:0004842 centriole; cytoplasm; heme binding; metal ion binding; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR004939; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR009060; IPR015940; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) HERC2 CG11734 Drosophila melanogaster (Fruit fly) TR38447_c6_g2_i1 Q8NDN9 RCBT1_HUMAN 5.00E-127 GO:0007049; GO:0016568; GO:0005737; GO:0005634; GO:0006355; GO:0006351 "cell cycle; chromatin modification; cytoplasm; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR009091; IPR000408; RCC1 and BTB domain-containing protein 1 (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein) (Regulator of chromosome condensation and BTB domain-containing protein 1) RCBTB1 CLLD7 E4.5 Homo sapiens (Human) TR38448_c2_g1_i1 Q5ZMW3 API5_CHICK 0 GO:0006915; GO:0005737; GO:0017134; GO:0043066; GO:0005681 apoptotic process; cytoplasm; fibroblast growth factor binding; negative regulation of apoptotic process; spliceosomal complex IPR008383; IPR011989; IPR016024; Apoptosis inhibitor 5 (API-5) API5 RCJMB04_1a12 Gallus gallus (Chicken) TR38449_c0_g1_i1 Q5RCU5 CBR1_PONAB 4.00E-71 GO:0047021; GO:0004090; GO:0005737; GO:0017144; GO:0050221; GO:0042373 15-hydroxyprostaglandin dehydrogenase (NADP+) activity; carbonyl reductase (NADPH) activity; cytoplasm; drug metabolic process; prostaglandin-E2 9-reductase activity; vitamin K metabolic process IPR002198; IPR002347; IPR016040; IPR020904; Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) CBR1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38449_c0_g1_i2 Q9ZUH5 SDR2B_ARATH 7.00E-18 GO:0008106; GO:0005829; GO:0016491 alcohol dehydrogenase (NADP+) activity; cytosol; oxidoreductase activity IPR002198; IPR002347; IPR016040; Short-chain dehydrogenase/reductase 2b (AtSDR2b) (EC 1.1.1.-) SDR2b SDR2 At2g24190 F27D4.10 Arabidopsis thaliana (Mouse-ear cress) TR38449_c0_g1_i4 P16152 CBR1_HUMAN 3.00E-71 GO:0047021; GO:0004090; GO:0019371; GO:0005829; GO:0017144; GO:0016655; GO:0050221; GO:0042373 "15-hydroxyprostaglandin dehydrogenase (NADP+) activity; carbonyl reductase (NADPH) activity; cyclooxygenase pathway; cytosol; drug metabolic process; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; prostaglandin-E2 9-reductase activity; vitamin K metabolic process" IPR002198; IPR002347; IPR016040; IPR020904; Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.197) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) CBR1 CBR CRN Homo sapiens (Human) TR38449_c0_g1_i5 Q9M2E2 SDR1_ARATH 9.00E-17 GO:0047501; GO:0006952 (+)-neomenthol dehydrogenase activity; defense response IPR002198; IPR002347; IPR016040; (+)-neomenthol dehydrogenase (EC 1.1.1.208) (Menthone:neomenthol reductase) (Short-chain dehydrogenase/reductase 1) (AtSDR1) SDR1 At3g61220 T20K12.120 Arabidopsis thaliana (Mouse-ear cress) TR38449_c0_g1_i6 Q9P324 YI78_SCHPO 3.00E-06 GO:0005829; GO:0005634; GO:0016491 cytosol; nucleus; oxidoreductase activity IPR002198; IPR002347; IPR016040; Uncharacterized oxidoreductase C977.08/C1348.09 (EC 1.-.-.-) SPAC977.08; SPAC1348.09 SPBC1348.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38450_c3_g1_i1 Q7ZVP8 TM38B_DANRE 2.00E-43 GO:0005789; GO:0016021; GO:0005267 endoplasmic reticulum membrane; integral to membrane; potassium channel activity IPR007866; Trimeric intracellular cation channel type B (TRIC-B) (TRICB) (Transmembrane protein 38B) tmem38b zgc:55815 Danio rerio (Zebrafish) (Brachydanio rerio) TR38451_c0_g1_i3 O14302 CYK3_SCHPO 1.00E-06 GO:0005826; GO:0030428; GO:0051286; GO:0000281 actomyosin contractile ring; cell septum; cell tip; mitotic cytokinesis IPR001452; IPR002931; cytokinesis protein 3 cyk3 SPAC9G1.06c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38451_c0_g1_i4 Q8C8H8 KY_MOUSE 4.00E-46 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) TR38451_c0_g1_i5 Q8NBH2 KY_HUMAN 1.00E-27 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) KY Homo sapiens (Human) TR38454_c8_g3_i1 Q6P2K3 CC067_MOUSE 4.00E-07 IPR007714; Uncharacterized protein C3orf67 homolog Mus musculus (Mouse) TR38456_c0_g1_i1 Q04786 HEX_VIBVL 2.00E-152 GO:0004563; GO:0006032; GO:0030247; GO:0000272 beta-N-acetylhexosaminidase activity; chitin catabolic process; polysaccharide binding; polysaccharide catabolic process IPR025705; IPR008965; IPR012291; IPR004866; IPR013812; IPR015883; IPR015882; IPR013781; IPR017853; IPR014756; Glycan degradation; chitin degradation. Beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Chitobiase) (N-acetyl-beta-glucosaminidase) hex Vibrio vulnificus TR38456_c0_g1_i2 P86956 HEX_PINMA 1.00E-49 GO:0004563; GO:0005975; GO:0006032; GO:0005576; GO:0030247 beta-N-acetylhexosaminidase activity; carbohydrate metabolic process; chitin catabolic process; extracellular region; polysaccharide binding IPR025705; IPR008965; IPR012291; IPR004866; IPR015883; IPR013781; IPR017853; Glycan degradation; chitin degradation. Putative beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Chitobiase) (N-acetyl-beta-glucosaminidase) Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) TR38459_c1_g1_i1 P05619 ILEU_HORSE 3.00E-51 GO:0005737; GO:0005615; GO:0004867 cytoplasm; extracellular space; serine-type endopeptidase inhibitor activity IPR023795; IPR023796; IPR000215; Leukocyte elastase inhibitor (LEI) (Serpin B1) SERPINB1 ELANH2 Equus caballus (Horse) TR38460_c0_g1_i1 P34422 DPF6_CAEEL 3.00E-17 GO:0004177; GO:0016021; GO:0005886; GO:0006508; GO:0008236 aminopeptidase activity; integral to membrane; plasma membrane; proteolysis; serine-type peptidase activity IPR011042; IPR001375; Dipeptidyl peptidase family member 6 (EC 3.4.14.-) dpf-6 F44B9.1 Caenorhabditis elegans TR38460_c0_g1_i3 P39839 YUXL_BACSU 5.00E-18 GO:0006508; GO:0008236 proteolysis; serine-type peptidase activity IPR011042; IPR011659; IPR001375; Uncharacterized peptidase YuxL (EC 3.4.21.-) yuxL BSU32230 Bacillus subtilis (strain 168) TR38461_c2_g1_i1 Q9EPX2 PPN_MOUSE 3.00E-22 GO:0005604; GO:0004222; GO:0004867; GO:0008270 basement membrane; metalloendopeptidase activity; serine-type endopeptidase inhibitor activity; zinc ion binding IPR010294; IPR007110; IPR013783; IPR013098; IPR003598; IPR013106; IPR013273; IPR010909; IPR002223; IPR020901; IPR000884; Papilin Papln Mus musculus (Mouse) TR38461_c3_g2_i1 P58397 ATS12_HUMAN 8.00E-09 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAM-TS 12) (ADAM-TS12) (ADAMTS-12) (EC 3.4.24.-) ADAMTS12 UNQ1918/PRO4389 Homo sapiens (Human) TR38461_c3_g3_i1 P97857 ATS1_MOUSE 2.00E-10 GO:0005604; GO:0031410; GO:0060347; GO:0008201; GO:0001822; GO:0004222; GO:0016525; GO:0001542; GO:0006508; GO:0008270 basement membrane; cytoplasmic vesicle; heart trabecula formation; heparin binding; kidney development; metalloendopeptidase activity; negative regulation of angiogenesis; ovulation from ovarian follicle; proteolysis; zinc ion binding IPR006586; IPR010294; IPR024079; IPR013274; IPR001590; IPR013273; IPR002870; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS 1) (ADAM-TS1) (ADAMTS-1) (EC 3.4.24.-) Adamts1 Mus musculus (Mouse) TR38461_c4_g1_i1 Q3UTY6 THSD4_MOUSE 8.00E-19 GO:0048251; GO:0004222; GO:0001527 elastic fiber assembly; metalloendopeptidase activity; microfibril IPR010294; IPR010909; IPR000884; Thrombospondin type-1 domain-containing protein 4 (A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6) (ADAMTS-like protein 6) (ADAMTSL-6) (ADAMTS-like protein 4) (ADAMTSL-4) Thsd4 Mus musculus (Mouse) TR38461_c4_g2_i1 Q9P2N4 ATS9_HUMAN 5.00E-65 GO:0005615; GO:0006516; GO:0004222; GO:0008237; GO:0007275; GO:0045636; GO:0005578; GO:0006508; GO:0008270 extracellular space; glycoprotein catabolic process; metalloendopeptidase activity; metallopeptidase activity; multicellular organismal development; positive regulation of melanocyte differentiation; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR012314; IPR001590; IPR013273; IPR002870; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAM-TS 9) (ADAM-TS9) (ADAMTS-9) (EC 3.4.24.-) ADAMTS9 KIAA1312 Homo sapiens (Human) TR38462_c0_g1_i2 Q9H1V8 S6A17_HUMAN 0 GO:0032328; GO:0030054; GO:0015816; GO:0005887; GO:0015820; GO:0005328; GO:0015824; GO:0008021; GO:0030672 alanine transport; cell junction; glycine transport; integral to plasma membrane; leucine transport; neurotransmitter:sodium symporter activity; proline transport; synaptic vesicle; synaptic vesicle membrane IPR000175; IPR002438; Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17) SLC6A17 NTT4 Homo sapiens (Human) TR38463_c1_g2_i4 Q9UJW0 DCTN4_HUMAN 8.00E-140 GO:0019886; GO:0005813; GO:0005829; GO:0005869; GO:0005634 Q01484 antigen processing and presentation of exogenous peptide antigen via MHC class II; centrosome; cytosol; dynactin complex; nucleus IPR008603; Dynactin subunit 4 (Dyn4) (Dynactin subunit p62) DCTN4 Homo sapiens (Human) TR38463_c1_g2_i5 Q9UJW0 DCTN4_HUMAN 2.00E-138 GO:0019886; GO:0005813; GO:0005829; GO:0005869; GO:0005634 Q01484 antigen processing and presentation of exogenous peptide antigen via MHC class II; centrosome; cytosol; dynactin complex; nucleus IPR008603; Dynactin subunit 4 (Dyn4) (Dynactin subunit p62) DCTN4 Homo sapiens (Human) TR38464_c0_g1_i1 Q5F201 WDR16_MOUSE 0 GO:0005737; GO:0043231 cytoplasm; intracellular membrane-bounded organelle IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 16 Wdr16 Mus musculus (Mouse) TR38465_c1_g1_i1 Q9SAE4 C71BT_ARATH 4.00E-12 GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705; GO:0009506 "heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; plasmodesma" IPR001128; IPR017972; IPR002401; Cytochrome P450 71B29 (EC 1.14.-.-) CYP71B29 At1g13100 F3F19.12 Arabidopsis thaliana (Mouse-ear cress) TR38465_c1_g1_i2 Q9VA27 CP4C3_DROME 1.00E-154 GO:0005789; GO:0020037; GO:0005506; GO:0004497; GO:0016705 "endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Cytochrome P450 4c3 (EC 1.14.-.-) (CYPIVC3) Cyp4c3 CG1438 Drosophila melanogaster (Fruit fly) TR38465_c1_g1_i3 Q5RCN6 CP4V2_PONAB 6.00E-166 GO:0005789; GO:0010430; GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705 "endoplasmic reticulum membrane; fatty acid omega-oxidation; heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Cytochrome P450 4V2 (EC 1.14.13.-) CYP4V2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38465_c1_g1_i4 Q27589 CP4D2_DROME 3.00E-107 GO:0005789; GO:0020037; GO:0005506; GO:0004497; GO:0016705 "endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Cytochrome P450 4d2 (EC 1.14.-.-) (CYPIVD2) Cyp4d2 CG3466 Drosophila melanogaster (Fruit fly) TR38465_c1_g1_i5 Q5RCN6 CP4V2_PONAB 2.00E-168 GO:0005789; GO:0010430; GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705 "endoplasmic reticulum membrane; fatty acid omega-oxidation; heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Cytochrome P450 4V2 (EC 1.14.13.-) CYP4V2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38466_c0_g4_i1 Q6PE18 P4K2A_DANRE 0 GO:0004430; GO:0035651; GO:0005524; GO:0030054; GO:0016023; GO:0031410; GO:0030425; GO:0005768; GO:0035838; GO:0044231; GO:0045121; GO:0005739; GO:0043025; GO:0042734 1-phosphatidylinositol 4-kinase activity; AP-3 adaptor complex binding; ATP binding; cell junction; cytoplasmic membrane-bounded vesicle; cytoplasmic vesicle; dendrite; endosome; growing cell tip; host cell presynaptic membrane; membrane raft; mitochondrion; neuronal cell body; presynaptic membrane IPR000403; Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) pi4k2a pi4kii si:ch211-197k17.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR38466_c0_g4_i2 Q28G26 P4K2B_XENTR 1.00E-177 GO:0004430; GO:0005524; GO:0005737; GO:0016020 1-phosphatidylinositol 4-kinase activity; ATP binding; cytoplasm; membrane IPR000403; Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) pi4k2b TGas067g11.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38467_c0_g2_i1 Q9JI19 FIBP_MOUSE 3.00E-71 GO:0012505; GO:0016020; GO:0005634 endomembrane system; membrane; nucleus IPR008614; Acidic fibroblast growth factor intracellular-binding protein (aFGF intracellular-binding protein) (FGF-1 intracellular-binding protein) Fibp Mus musculus (Mouse) TR38470_c1_g2_i1 Q9WVL0 MAAI_MOUSE 9.00E-91 GO:0006559; GO:0004364; GO:0016034; GO:0005739; GO:0006572 L-phenylalanine catabolic process; glutathione transferase activity; maleylacetoacetate isomerase activity; mitochondrion; tyrosine catabolic process IPR010987; IPR004045; IPR004046; IPR005955; IPR012336; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6. Maleylacetoacetate isomerase (MAAI) (EC 5.2.1.2) (GSTZ1-1) (Glutathione S-transferase zeta 1) (EC 2.5.1.18) Gstz1 Maai Mus musculus (Mouse) TR38470_c1_g2_i5 Q9WVL0 MAAI_MOUSE 5.00E-90 GO:0006559; GO:0004364; GO:0016034; GO:0005739; GO:0006572 L-phenylalanine catabolic process; glutathione transferase activity; maleylacetoacetate isomerase activity; mitochondrion; tyrosine catabolic process IPR010987; IPR004045; IPR004046; IPR005955; IPR012336; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6. Maleylacetoacetate isomerase (MAAI) (EC 5.2.1.2) (GSTZ1-1) (Glutathione S-transferase zeta 1) (EC 2.5.1.18) Gstz1 Maai Mus musculus (Mouse) TR38470_c1_g2_i7 Q18938 MAAI_CAEEL 8.00E-66 GO:0006559; GO:0005737; GO:0016034; GO:0006572 Itself L-phenylalanine catabolic process; cytoplasm; maleylacetoacetate isomerase activity; tyrosine catabolic process IPR010987; IPR004045; IPR005955; IPR012336; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6. Probable maleylacetoacetate isomerase (MAAI) (EC 5.2.1.2) (Glutathione S-transferase gst-42) gst-42 D1053.1 Caenorhabditis elegans TR38470_c1_g2_i8 Q9VHD2 MAAI2_DROME 4.00E-87 GO:0006559; GO:0005737; GO:0006749; GO:0004364; GO:0016034; GO:0006572 L-phenylalanine catabolic process; cytoplasm; glutathione metabolic process; glutathione transferase activity; maleylacetoacetate isomerase activity; tyrosine catabolic process IPR010987; IPR004045; IPR004046; IPR005955; IPR012336; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6. Probable maleylacetoacetate isomerase 2 (MAAI 2) (EC 5.2.1.2) (Glutathione S-transferase zeta 2) (EC 2.5.1.18) GstZ2 CG9363 Drosophila melanogaster (Fruit fly) TR38471_c0_g1_i1 Q9BZ72 PITM2_HUMAN 1.00E-60 GO:0005509; GO:0012505; GO:0016021; GO:0043231; GO:0008289; GO:0008152; GO:0006810 calcium ion binding; endomembrane system; integral to membrane; intracellular membrane-bounded organelle; lipid binding; metabolic process; transport IPR004177; IPR023214; IPR013209; IPR001666; IPR023393; "Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3)" PITPNM2 KIAA1457 NIR3 Homo sapiens (Human) TR38471_c0_g1_i2 Q9UKF7 PITC1_HUMAN 8.00E-117 GO:0005737; GO:0008289; GO:0008526; GO:0007165 Q6RW13 cytoplasm; lipid binding; phosphatidylinositol transporter activity; signal transduction IPR001666; IPR023393; Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (M-rdgB beta) (MrdgBbeta) (Retinal degeneration B homolog beta) (RdgBbeta) PITPNC1 Homo sapiens (Human) TR38473_c0_g1_i1 E1C3S7 TDRD7_CHICK 7.00E-22 GO:0043186; GO:0033391; GO:0007281; GO:0070306; GO:0002089; GO:0003729; GO:0010608; GO:0035770; GO:0007283 P granule; chromatoid body; germ cell development; lens fiber cell differentiation; lens morphogenesis in camera-type eye; mRNA binding; posttranscriptional regulation of gene expression; ribonucleoprotein granule; spermatogenesis IPR025605; IPR002999; Tudor domain-containing protein 7 TDRD7 Gallus gallus (Chicken) TR38473_c0_g1_i2 A9CPT4 TDRD1_ORYLA 4.00E-14 GO:0043046; GO:0031047; GO:0007281; GO:0007126; GO:0046872; GO:0007275; GO:0071546; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; gene silencing by RNA; germ cell development; meiosis; metal ion binding; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002999; IPR002893; Tudor domain-containing protein 1 tdrd1 Oryzias latipes (Medaka fish) (Japanese ricefish) TR38473_c0_g1_i3 Q09285 YQK1_CAEEL 3.00E-07 GO:0003723 RNA binding IPR004087; IPR004088; IPR002999; KH domain-containing protein C56G2.1 C56G2.1/C56G2.2 Caenorhabditis elegans TR38473_c0_g1_i4 E1C3S7 TDRD7_CHICK 2.00E-21 GO:0043186; GO:0033391; GO:0007281; GO:0070306; GO:0002089; GO:0003729; GO:0010608; GO:0035770; GO:0007283 P granule; chromatoid body; germ cell development; lens fiber cell differentiation; lens morphogenesis in camera-type eye; mRNA binding; posttranscriptional regulation of gene expression; ribonucleoprotein granule; spermatogenesis IPR025605; IPR002999; Tudor domain-containing protein 7 TDRD7 Gallus gallus (Chicken) TR38474_c1_g2_i1 P59723 HIF1N_DANRE 5.00E-06 GO:0046872; GO:0005634; GO:0036140; GO:0042265; GO:0042264; GO:0036139; GO:0036138; GO:0048471; GO:0006355; GO:0006351 "metal ion binding; nucleus; peptidyl-asparagine 3-dioxygenase activity; peptidyl-asparagine hydroxylation; peptidyl-aspartic acid hydroxylation; peptidyl-histidine dioxygenase activity; peptidyl-histidine hydroxylation; perinuclear region of cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR027452; IPR003347; Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30) (EC 1.14.11.n4) (Hypoxia-inducible factor asparagine hydroxylase) hif1an si:rp71-68n3.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR38474_c1_g2_i3 Q9CXT6 KDM8_MOUSE 4.00E-17 GO:0000086; GO:0003682; GO:0051864; GO:0046872; GO:0005634; GO:0045893; GO:0006351 "G2/M transition of mitotic cell cycle; chromatin binding; histone demethylase activity (H3-K36 specific); metal ion binding; nucleus; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003347; Lysine-specific demethylase 8 (EC 1.14.11.27) (JmjC domain-containing protein 5) (Jumonji domain-containing protein 5) Kdm8 Jmjd5 Mus musculus (Mouse) TR38475_c0_g3_i1 Q96AV8 E2F7_HUMAN 2.00E-80 GO:0030330; GO:0060718; GO:0001047; GO:0070365; GO:2000134; GO:0008285; GO:0032466; GO:0071930; GO:0005634; GO:0032877; GO:0045944; GO:0003700; GO:0002040; GO:0003714; GO:0005667; GO:0006351; GO:0060707 Itself; A0AVK6 "DNA damage response, signal transduction by p53 class mediator; chorionic trophoblast cell differentiation; core promoter binding; hepatocyte differentiation; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell proliferation; negative regulation of cytokinesis; negative regulation of transcription involved in G1/S transition of mitotic cell cycle; nucleus; positive regulation of DNA endoreduplication; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sprouting angiogenesis; transcription corepressor activity; transcription factor complex; transcription, DNA-dependent; trophoblast giant cell differentiation" IPR015633; IPR003316; IPR011991; Transcription factor E2F7 (E2F-7) E2F7 Homo sapiens (Human) TR38475_c0_g3_i2 A0AVK6 E2F8_HUMAN 4.00E-80 GO:0033301; GO:0008283; GO:0060718; GO:0001047; GO:0070365; GO:0032466; GO:0000122; GO:0005634; GO:0032877; GO:0045944; GO:0003700; GO:0002040; GO:0003714; GO:0005667; GO:0006351; GO:0060707 Q96AV8 "cell cycle comprising mitosis without cytokinesis; cell proliferation; chorionic trophoblast cell differentiation; core promoter binding; hepatocyte differentiation; negative regulation of cytokinesis; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of DNA endoreduplication; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sprouting angiogenesis; transcription corepressor activity; transcription factor complex; transcription, DNA-dependent; trophoblast giant cell differentiation" IPR015633; IPR003316; IPR011991; Transcription factor E2F8 (E2F-8) E2F8 Homo sapiens (Human) TR38476_c0_g1_i2 Q9H8E8 CSR2B_HUMAN 6.00E-115 GO:0005671; GO:0030274; GO:0022402; GO:0005737; GO:0009790; GO:0043966; GO:0004402 Q9NS73 Ada2/Gcn5/Ada3 transcription activator complex; LIM domain binding; cell cycle process; cytoplasm; embryo development; histone H3 acetylation; histone acetyltransferase activity IPR016181; IPR000182; Cysteine-rich protein 2-binding protein (CSRP2-binding protein) (ADA2A-containing complex subunit 2) (ATAC2) (CRP2-binding partner) (CRP2BP) CSRP2BP Homo sapiens (Human) TR38476_c0_g1_i5 Q9H8E8 CSR2B_HUMAN 4.00E-115 GO:0005671; GO:0030274; GO:0022402; GO:0005737; GO:0009790; GO:0043966; GO:0004402 Q9NS73 Ada2/Gcn5/Ada3 transcription activator complex; LIM domain binding; cell cycle process; cytoplasm; embryo development; histone H3 acetylation; histone acetyltransferase activity IPR016181; IPR000182; Cysteine-rich protein 2-binding protein (CSRP2-binding protein) (ADA2A-containing complex subunit 2) (ATAC2) (CRP2-binding partner) (CRP2BP) CSRP2BP Homo sapiens (Human) TR38477_c3_g1_i1 P16157 ANK1_HUMAN 2.00E-18 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR38477_c4_g4_i1 Q75UQ2 CFDP1_RAT 7.00E-41 GO:0007155; GO:0007275; GO:0043066; GO:0042127; GO:0008360 cell adhesion; multicellular organismal development; negative regulation of apoptotic process; regulation of cell proliferation; regulation of cell shape IPR011421; IPR027124; Craniofacial development protein 1 (Bucentaur) Cfdp1 Bcnt Rattus norvegicus (Rat) TR38477_c4_g4_i2 Q6CKH1 SWC5_KLULA 9.00E-08 GO:0016568; GO:0005634; GO:0006355; GO:0006351 "chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011421; IPR027124; SWR1-complex protein 5 SWC5 KLLA0F10725g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR38478_c3_g5_i5 O95714 HERC2_HUMAN 3.00E-07 GO:0006281; GO:0032183; GO:0005814; GO:0005737; GO:0005085; GO:0020037; GO:0006886; GO:0005634; GO:0042787; GO:0004842; GO:0008270 DNA repair; SUMO binding; centriole; cytoplasm; guanyl-nucleotide exchange factor activity; heme binding; intracellular protein transport; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR004939; IPR006624; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) HERC2 Homo sapiens (Human) TR38478_c3_g5_i9 Q69ZR2 HECD1_MOUSE 9.00E-06 GO:0005737; GO:0046872; GO:0001843; GO:0005634; GO:0042787; GO:0004842 cytoplasm; metal ion binding; neural tube closure; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR002110; IPR020683; IPR011989; IPR016024; IPR008979; IPR000569; IPR010606; IPR012919; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HECTD1 (EC 6.3.2.-) (HECT domain-containing protein 1) (Protein open mind) Hectd1 Kiaa1131 Opm Mus musculus (Mouse) TR38478_c3_g7_i1 Q4U2R1 HERC2_MOUSE 3.00E-07 GO:0006281; GO:0032183; GO:0005814; GO:0020037; GO:0005743; GO:0005634; GO:0042787; GO:0007283; GO:0004842; GO:0008270 DNA repair; SUMO binding; centriole; heme binding; mitochondrial inner membrane; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; spermatogenesis; ubiquitin-protein ligase activity; zinc ion binding IPR004939; IPR006624; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) Herc2 Jdf2 Kiaa0393 Rjs Mus musculus (Mouse) TR38478_c3_g7_i3 Q9VUX2 MIB_DROME 3.00E-06 GO:0007219; GO:0045179; GO:0005829; GO:0006897; GO:0046331; GO:0045747; GO:0008104; GO:0007423; GO:0004842; GO:0008270 Notch signaling pathway; apical cortex; cytosol; endocytosis; lateral inhibition; positive regulation of Notch signaling pathway; protein localization; sensory organ development; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase mind-bomb (EC 6.3.2.-) (Mind bomb homolog) (D-mib) mib1 mind-bomb CG5841 Drosophila melanogaster (Fruit fly) TR38480_c0_g1_i3 Q5DRK1 ENTP8_RAT 6.00E-99 GO:0005524; GO:0016787; GO:0016021; GO:0046872; GO:0005886 ATP binding; hydrolase activity; integral to membrane; metal ion binding; plasma membrane IPR000407; Ectonucleoside triphosphate diphosphohydrolase 8 (E-NTPDase 8) (NTPDase 8) (NTPDase8) (EC 3.6.1.5) Entpd8 Rattus norvegicus (Rat) TR38480_c0_g1_i4 Q5DRK1 ENTP8_RAT 6.00E-99 GO:0005524; GO:0016787; GO:0016021; GO:0046872; GO:0005886 ATP binding; hydrolase activity; integral to membrane; metal ion binding; plasma membrane IPR000407; Ectonucleoside triphosphate diphosphohydrolase 8 (E-NTPDase 8) (NTPDase 8) (NTPDase8) (EC 3.6.1.5) Entpd8 Rattus norvegicus (Rat) TR38480_c0_g1_i7 O93295 ENTP8_CHICK 2.00E-96 GO:0005524; GO:0016787; GO:0016021; GO:0046872; GO:0005886 ATP binding; hydrolase activity; integral to membrane; metal ion binding; plasma membrane IPR000407; Ectonucleoside triphosphate diphosphohydrolase 8 (E-NTPDase 8) (NTPDase 8) (NTPDase8) (EC 3.6.1.5) (Liver ecto-ATP diphosphohydrolase) ENTPD8 Gallus gallus (Chicken) TR38480_c0_g1_i9 Q5DRK1 ENTP8_RAT 7.00E-99 GO:0005524; GO:0016787; GO:0016021; GO:0046872; GO:0005886 ATP binding; hydrolase activity; integral to membrane; metal ion binding; plasma membrane IPR000407; Ectonucleoside triphosphate diphosphohydrolase 8 (E-NTPDase 8) (NTPDase 8) (NTPDase8) (EC 3.6.1.5) Entpd8 Rattus norvegicus (Rat) TR38481_c2_g1_i2 Q9UBQ7 GRHPR_HUMAN 2.00E-101 GO:0051287; GO:0070402; GO:0034641; GO:0007588; GO:0008465; GO:0046487; GO:0030267; GO:0016618; GO:0005782; GO:0042803; GO:0051259 NAD binding; NADPH binding; cellular nitrogen compound metabolic process; excretion; glycerate dehydrogenase activity; glyoxylate metabolic process; glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; peroxisomal matrix; protein homodimerization activity; protein oligomerization IPR006139; IPR006140; IPR016040; Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81) GRHPR GLXR MSTP035 Homo sapiens (Human) TR38481_c2_g1_i3 A1RYE4 GYAR_THEPD 7.00E-77 GO:0051287; GO:0005737; GO:0047964 NAD binding; cytoplasm; glyoxylate reductase activity IPR006139; IPR006140; IPR023519; IPR016040; Glyoxylate reductase (EC 1.1.1.26) gyaR Tpen_0823 Thermofilum pendens (strain Hrk 5) TR38482_c0_g3_i1 P15498 VAV_HUMAN 1.00E-105 GO:0038095; GO:0038096; GO:0030676; GO:0042110; GO:0031295; GO:0097190; GO:0005829; GO:0007173; GO:0008543; GO:0005085; GO:0045087; GO:0007229; GO:0046872; GO:0048011; GO:0048015; GO:0005543; GO:0005886; GO:0030168; GO:0043065; GO:0045785; GO:0043087; GO:0035023; GO:0051056; GO:0003700; GO:0007264 Q8IZP0; P00519; P62993; Q07666; Q13094; P08487; P63000; P78314; Q8N720 Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; Rac guanyl-nucleotide exchange factor activity; T cell activation; T cell costimulation; apoptotic signaling pathway; cytosol; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; guanyl-nucleotide exchange factor activity; innate immune response; integrin-mediated signaling pathway; metal ion binding; neurotrophin TRK receptor signaling pathway; phosphatidylinositol-mediated signaling; phospholipid binding; plasma membrane; platelet activation; positive regulation of apoptotic process; positive regulation of cell adhesion; regulation of GTPase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; sequence-specific DNA binding transcription factor activity; small GTPase mediated signal transduction IPR001715; IPR000219; IPR001331; IPR011993; IPR001849; IPR002219; IPR000980; IPR001452; IPR003096; Proto-oncogene vav VAV1 VAV Homo sapiens (Human) TR38482_c0_g3_i3 Q9NHV9 VAV_DROME 7.00E-58 GO:0030676; GO:0031532; GO:0007015; GO:0032863; GO:0007155; GO:0016477; GO:0007417; GO:0007391; GO:0035556; GO:0035011; GO:0046872; GO:0007520; GO:0007424; GO:0005543; GO:0072499; GO:0008360 Rac guanyl-nucleotide exchange factor activity; actin cytoskeleton reorganization; actin filament organization; activation of Rac GTPase activity; cell adhesion; cell migration; central nervous system development; dorsal closure; intracellular signal transduction; melanotic encapsulation of foreign target; metal ion binding; myoblast fusion; open tracheal system development; phospholipid binding; photoreceptor cell axon guidance; regulation of cell shape IPR001715; IPR000219; IPR011993; IPR001849; IPR002219; IPR000980; IPR001452; Protein vav (DroVav) (dVAV) Vav CG7893 Drosophila melanogaster (Fruit fly) TR38482_c0_g3_i4 Q9NHV9 VAV_DROME 1.00E-58 GO:0030676; GO:0031532; GO:0007015; GO:0032863; GO:0007155; GO:0016477; GO:0007417; GO:0007391; GO:0035556; GO:0035011; GO:0046872; GO:0007520; GO:0007424; GO:0005543; GO:0072499; GO:0008360 Rac guanyl-nucleotide exchange factor activity; actin cytoskeleton reorganization; actin filament organization; activation of Rac GTPase activity; cell adhesion; cell migration; central nervous system development; dorsal closure; intracellular signal transduction; melanotic encapsulation of foreign target; metal ion binding; myoblast fusion; open tracheal system development; phospholipid binding; photoreceptor cell axon guidance; regulation of cell shape IPR001715; IPR000219; IPR011993; IPR001849; IPR002219; IPR000980; IPR001452; Protein vav (DroVav) (dVAV) Vav CG7893 Drosophila melanogaster (Fruit fly) TR38482_c0_g3_i5 P42684 ABL2_HUMAN 7.00E-11 GO:0005524; GO:0015629; GO:0051015; GO:0051017; GO:0003785; GO:0007411; GO:0007155; GO:0071300; GO:0005829; GO:0000287; GO:0030145; GO:0004715; GO:0010976; GO:0051353; GO:2000249; GO:0010506; GO:0030155; GO:2000145; GO:0030100; GO:0007165 Q8IZP0; P46108; P00533; P04626; P21860; Q15303; P06241; P62993; P16333; P27986; P19174; Q13671; P12931 ATP binding; actin cytoskeleton; actin filament binding; actin filament bundle assembly; actin monomer binding; axon guidance; cell adhesion; cellular response to retinoic acid; cytosol; magnesium ion binding; manganese ion binding; non-membrane spanning protein tyrosine kinase activity; positive regulation of neuron projection development; positive regulation of oxidoreductase activity; regulation of actin cytoskeleton reorganization; regulation of autophagy; regulation of cell adhesion; regulation of cell motility; regulation of endocytosis; signal transduction IPR015015; IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Abelson tyrosine-protein kinase 2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) ABL2 ABLL ARG Homo sapiens (Human) TR38482_c0_g3_i6 Q60992 VAV2_MOUSE 5.00E-102 GO:0005089; GO:0001525; GO:0016477; GO:0005829; GO:0005085; GO:0030032; GO:0046872; GO:0005543; GO:0005886; GO:0043552; GO:0035023; GO:0007264 Rho guanyl-nucleotide exchange factor activity; angiogenesis; cell migration; cytosol; guanyl-nucleotide exchange factor activity; lamellipodium assembly; metal ion binding; phospholipid binding; plasma membrane; positive regulation of phosphatidylinositol 3-kinase activity; regulation of Rho protein signal transduction; small GTPase mediated signal transduction IPR022613; IPR001715; IPR000219; IPR001331; IPR011993; IPR001849; IPR002219; IPR000980; IPR011511; IPR001452; Guanine nucleotide exchange factor VAV2 (VAV-2) Vav2 Mus musculus (Mouse) TR38482_c0_g3_i7 Q7Z6J4 FGD2_HUMAN 3.00E-06 GO:0005794; GO:0005089; GO:0030036; GO:0097190; GO:0005856; GO:0005829; GO:0031901; GO:0046847; GO:0005085; GO:0030027; GO:0046872; GO:0048011; GO:0005634; GO:0005543; GO:0043065; GO:0043088; GO:0008360; GO:0001726; GO:0032587; GO:0031267; GO:0007264 Golgi apparatus; Rho guanyl-nucleotide exchange factor activity; actin cytoskeleton organization; apoptotic signaling pathway; cytoskeleton; cytosol; early endosome membrane; filopodium assembly; guanyl-nucleotide exchange factor activity; lamellipodium; metal ion binding; neurotrophin TRK receptor signaling pathway; nucleus; phospholipid binding; positive regulation of apoptotic process; regulation of Cdc42 GTPase activity; regulation of cell shape; ruffle; ruffle membrane; small GTPase binding; small GTPase mediated signal transduction IPR000219; IPR011993; IPR001849; IPR000306; IPR017455; IPR011011; IPR013083; "FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4)" FGD2 ZFYVE4 Homo sapiens (Human) TR38482_c0_g4_i1 P15498 VAV_HUMAN 1.00E-62 GO:0038095; GO:0038096; GO:0030676; GO:0042110; GO:0031295; GO:0097190; GO:0005829; GO:0007173; GO:0008543; GO:0005085; GO:0045087; GO:0007229; GO:0046872; GO:0048011; GO:0048015; GO:0005543; GO:0005886; GO:0030168; GO:0043065; GO:0045785; GO:0043087; GO:0035023; GO:0051056; GO:0003700; GO:0007264 Q8IZP0; P00519; P62993; Q07666; Q13094; P08487; P63000; P78314; Q8N720 Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; Rac guanyl-nucleotide exchange factor activity; T cell activation; T cell costimulation; apoptotic signaling pathway; cytosol; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; guanyl-nucleotide exchange factor activity; innate immune response; integrin-mediated signaling pathway; metal ion binding; neurotrophin TRK receptor signaling pathway; phosphatidylinositol-mediated signaling; phospholipid binding; plasma membrane; platelet activation; positive regulation of apoptotic process; positive regulation of cell adhesion; regulation of GTPase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; sequence-specific DNA binding transcription factor activity; small GTPase mediated signal transduction IPR001715; IPR000219; IPR001331; IPR011993; IPR001849; IPR002219; IPR000980; IPR001452; IPR003096; Proto-oncogene vav VAV1 VAV Homo sapiens (Human) TR38482_c0_g4_i2 Q8C033 ARHGA_MOUSE 2.00E-06 GO:0005089; GO:0035023 Rho guanyl-nucleotide exchange factor activity; regulation of Rho protein signal transduction IPR000219; IPR015943; IPR017986; Rho guanine nucleotide exchange factor 10 Arhgef10 Kiaa0294 Mus musculus (Mouse) TR38484_c0_g1_i1 Q9JI90 RNF14_MOUSE 3.00E-26 GO:0050681; GO:0005737; GO:0005634; GO:0045893; GO:0060765; GO:0032355; GO:0019787; GO:0006351; GO:0008270 "androgen receptor binding; cytoplasm; nucleus; positive regulation of transcription, DNA-dependent; regulation of androgen receptor signaling pathway; response to estradiol stimulus; small conjugating protein ligase activity; transcription, DNA-dependent; zinc ion binding" IPR006575; IPR016135; IPR002867; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase RNF14 (EC 6.3.2.-) (Androgen receptor-associated protein 54) (Protein Triad2) (RING finger protein 14) Rnf14 Ara54 Triad2 Mus musculus (Mouse) TR38484_c2_g1_i1 Q9P3U4 YKX2_SCHPO 2.00E-07 GO:0030437; GO:0005829; GO:0007127; GO:0005634; GO:0043161; GO:0035861; GO:0004842; GO:0008270 ascospore formation; cytosol; meiosis I; nucleus; proteasomal ubiquitin-dependent protein catabolic process; site of double-strand break; ubiquitin-protein ligase activity; zinc ion binding IPR018957; IPR002867; IPR001841; IPR013083; IPR017907; Uncharacterized RING finger protein C328.02 SPAC328.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38484_c7_g1_i2 B1H283 CA177_RAT 3.00E-65 IPR010736; Uncharacterized protein C1orf177 homolog Rattus norvegicus (Rat) TR38484_c8_g3_i1 Q9TXJ8 RECQ1_CAEEL 4.00E-11 GO:0005524; GO:0008026; GO:0006310; GO:0003676; GO:0005634 ATP binding; ATP-dependent helicase activity; DNA recombination; nucleic acid binding; nucleus IPR011545; IPR004589; IPR014001; IPR001650; IPR027417; IPR011991; Putative ATP-dependent DNA helicase Q1 (EC 3.6.4.12) K02F3.12 Caenorhabditis elegans TR38484_c8_g3_i2 Q9I920 BLM_CHICK 5.00E-14 GO:0005524; GO:0043140; GO:0004003; GO:0003677; GO:0000729; GO:0006310; GO:0006260; GO:0005634 ATP binding; ATP-dependent 3'-5' DNA helicase activity; ATP-dependent DNA helicase activity; DNA binding; DNA double-strand break processing; DNA recombination; DNA replication; nucleus IPR012532; IPR011545; IPR002464; IPR004589; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR018982; IPR011991; Bloom syndrome protein homolog (EC 3.6.4.12) (RecQ helicase homolog) (Fragment) BLM Gallus gallus (Chicken) TR38486_c0_g2_i1 O14234 CCH1_SCHPO 6.00E-57 GO:0005783; GO:0005789; GO:0005887; GO:0050850; GO:0032516; GO:0005245; GO:0005891 endoplasmic reticulum; endoplasmic reticulum membrane; integral to plasma membrane; positive regulation of calcium-mediated signaling; positive regulation of phosphoprotein phosphatase activity; voltage-gated calcium channel activity; voltage-gated calcium channel complex IPR027359; IPR005821; IPR002077; Calcium-channel protein cch1 cch1 SPAC6F6.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38486_c0_g3_i1 Q8IZF0 NALCN_HUMAN 0 GO:0016021; GO:0005886; GO:0005272; GO:0005244 P20309 integral to membrane; plasma membrane; sodium channel activity; voltage-gated ion channel activity IPR027359; IPR005821; Sodium leak channel non-selective protein (CanIon) (Voltage gated channel-like protein 1) NALCN VGCNL1 Homo sapiens (Human) TR38486_c0_g3_i2 Q8IZF0 NALCN_HUMAN 0 GO:0016021; GO:0005886; GO:0005272; GO:0005244 P20309 integral to membrane; plasma membrane; sodium channel activity; voltage-gated ion channel activity IPR027359; IPR005821; Sodium leak channel non-selective protein (CanIon) (Voltage gated channel-like protein 1) NALCN VGCNL1 Homo sapiens (Human) TR38488_c0_g2_i1 Q22712 MTMR3_CAEEL 1.00E-11 GO:0008340; GO:0016312; GO:0046855; GO:0008289; GO:0006629; GO:0040011; GO:0046872; GO:0035335; GO:0034594; GO:0045807; GO:0004725; GO:0046662 determination of adult lifespan; inositol bisphosphate phosphatase activity; inositol phosphate dephosphorylation; lipid binding; lipid metabolic process; locomotion; metal ion binding; peptidyl-tyrosine dephosphorylation; phosphatidylinositol trisphosphate phosphatase activity; positive regulation of endocytosis; protein tyrosine phosphatase activity; regulation of oviposition IPR010569; IPR017906; IPR016130; IPR000306; IPR017455; IPR011011; IPR013083; Myotubularin-related protein 3 (ceMTM3) (EC 3.1.3.48) (Myotubularin homologous protein 1) (ceMTMH1) mtm-3 T24A11.1 Caenorhabditis elegans TR38488_c0_g2_i2 Q86WG5 MTMRD_HUMAN 0 GO:0017112; GO:0016020; GO:0042552; GO:0016791; GO:0019208; GO:0035091; GO:0051262; GO:0005774 Rab guanyl-nucleotide exchange factor activity; membrane; myelination; phosphatase activity; phosphatase regulator activity; phosphatidylinositol binding; protein tetramerization; vacuolar membrane IPR005112; IPR001194; IPR004182; IPR010569; IPR017906; IPR011993; IPR001849; IPR022096; IPR005113; Myotubularin-related protein 13 (SET-binding factor 2) SBF2 CMT4B2 KIAA1766 MTMR13 Homo sapiens (Human) TR38488_c0_g2_i3 Q86WG5 MTMRD_HUMAN 0 GO:0017112; GO:0016020; GO:0042552; GO:0016791; GO:0019208; GO:0035091; GO:0051262; GO:0005774 Rab guanyl-nucleotide exchange factor activity; membrane; myelination; phosphatase activity; phosphatase regulator activity; phosphatidylinositol binding; protein tetramerization; vacuolar membrane IPR005112; IPR001194; IPR004182; IPR010569; IPR017906; IPR011993; IPR001849; IPR022096; IPR005113; Myotubularin-related protein 13 (SET-binding factor 2) SBF2 CMT4B2 KIAA1766 MTMR13 Homo sapiens (Human) TR3849_c0_g1_i1 Q5QQ53 XYLT_DROPS 1.00E-08 GO:0042732; GO:0000139; GO:0008375; GO:0030206; GO:0050650; GO:0005789; GO:0015012; GO:0016021; GO:0030158 D-xylose metabolic process; Golgi membrane; acetylglucosaminyltransferase activity; chondroitin sulfate biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process; endoplasmic reticulum membrane; heparan sulfate proteoglycan biosynthetic process; integral to membrane; protein xylosyltransferase activity IPR003406; IPR002889; IPR024448; Glycan metabolism; chondroitin sulfate biosynthesis. Glycan metabolism; heparan sulfate biosynthesis. Xylosyltransferase oxt (EC 2.4.2.26) (Peptide O-xylosyltransferase) oxt xt GA16815 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR38490_c4_g1_i1 Q5ZK10 NSF1C_CHICK 4.00E-111 GO:0007030; GO:0005795; GO:0008289; GO:0061025; GO:0005634 Golgi organization; Golgi stack; lipid binding; membrane fusion; nucleus IPR012989; IPR009060; IPR001012; NSFL1 cofactor p47 (p97 cofactor p47) NSFL1C RCJMB04_13o20 Gallus gallus (Chicken) TR38492_c0_g2_i1 O43913 ORC5_HUMAN 0 GO:0005524; GO:0006270; GO:0003688; GO:0000082; GO:0005737; GO:0005664; GO:0005654; GO:0000166 Q13415; Q13416; Q9UBD5; O43929 ATP binding; DNA replication initiation; DNA replication origin binding; G1/S transition of mitotic cell cycle; cytoplasm; nuclear origin of replication recognition complex; nucleoplasm; nucleotide binding IPR020796; IPR027417; Origin recognition complex subunit 5 ORC5 ORC5L Homo sapiens (Human) TR38492_c0_g2_i2 P50874 ORC5_YEAST 4.00E-11 GO:0005524; GO:0006270; GO:0003688; GO:0031261; GO:0030466; GO:0005664; GO:0005656; GO:0006267; GO:0031938 P32833; P54791 ATP binding; DNA replication initiation; DNA replication origin binding; DNA replication preinitiation complex; chromatin silencing at silent mating-type cassette; nuclear origin of replication recognition complex; nuclear pre-replicative complex; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; regulation of chromatin silencing at telomere IPR020796; IPR027417; Origin recognition complex subunit 5 (Origin recognition complex 53 kDa subunit) ORC5 YNL261W N0834 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR38492_c0_g2_i4 O43913 ORC5_HUMAN 0 GO:0005524; GO:0006270; GO:0003688; GO:0000082; GO:0005737; GO:0005664; GO:0005654; GO:0000166 Q13415; Q13416; Q9UBD5; O43929 ATP binding; DNA replication initiation; DNA replication origin binding; G1/S transition of mitotic cell cycle; cytoplasm; nuclear origin of replication recognition complex; nucleoplasm; nucleotide binding IPR020796; IPR027417; Origin recognition complex subunit 5 ORC5 ORC5L Homo sapiens (Human) TR38493_c1_g1_i1 Q86SQ9 DHDDS_HUMAN 5.00E-117 GO:0005789; GO:0006486; GO:0016765 "endoplasmic reticulum membrane; protein glycosylation; transferase activity, transferring alkyl or aryl (other than methyl) groups" IPR001441; IPR018520; Protein modification; protein glycosylation. Dehydrodolichyl diphosphate synthase (Dedol-PP synthase) (EC 2.5.1.-) (Cis-isoprenyltransferase) (CIT) (Cis-IPTase) (Epididymis tissue protein Li 189m) DHDDS HDS Homo sapiens (Human) TR38493_c3_g4_i3 Q6AVK1 COSA_ORYSJ 1.00E-29 IPR026111; IPR027817; Costars family protein Os03g0690000 LOC_Os03g48390 OsJ_011680 OSJNBa0022C08.7 Oryza sativa subsp. japonica (Rice) TR38493_c3_g4_i5 Q6AVK1 COSA_ORYSJ 1.00E-29 IPR026111; IPR027817; Costars family protein Os03g0690000 LOC_Os03g48390 OsJ_011680 OSJNBa0022C08.7 Oryza sativa subsp. japonica (Rice) TR38494_c0_g1_i1 Q6P0D9 CIAO1_DANRE 7.00E-14 GO:0097361; GO:0016226 CIA complex; iron-sulfur cluster assembly IPR015943; IPR001680; IPR019775; IPR017986; Probable cytosolic iron-sulfur protein assembly protein ciao1 (WD repeat-containing protein 39) ciao1 wdr39 si:dkey-49H9.1 zgc:55911 zgc:77394 Danio rerio (Zebrafish) (Brachydanio rerio) TR38494_c0_g1_i2 O43660 PLRG1_HUMAN 5.00E-34 GO:0071013; GO:0000398; GO:0016607; GO:0004871; GO:0003714 Q99459; P52272 "catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nuclear speck; signal transducer activity; transcription corepressor activity" IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Pleiotropic regulator 1 PLRG1 Homo sapiens (Human) TR38494_c0_g1_i3 Q4V7Y7 KTNB1_XENLA 0 GO:0051301; GO:0008352; GO:0005874; GO:0051013; GO:0007067; GO:0000922 cell division; katanin complex; microtubule; microtubule severing; mitosis; spindle pole IPR020472; IPR026962; IPR028021; IPR015943; IPR001680; IPR019775; IPR017986; Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) katnb1 Xenopus laevis (African clawed frog) TR38494_c0_g1_i4 O76071 CIAO1_HUMAN 1.00E-14 GO:0097361; GO:0071817; GO:0007059; GO:0016226; GO:0008284; GO:0006357; GO:0044281 CIA complex; MMXD complex; chromosome segregation; iron-sulfur cluster assembly; positive regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; small molecule metabolic process IPR015943; IPR001680; IPR019775; IPR017986; Probable cytosolic iron-sulfur protein assembly protein CIAO1 (WD repeat-containing protein 39) CIAO1 WDR39 Homo sapiens (Human) TR38494_c0_g1_i5 Q4V7Y7 KTNB1_XENLA 0 GO:0051301; GO:0008352; GO:0005874; GO:0051013; GO:0007067; GO:0000922 cell division; katanin complex; microtubule; microtubule severing; mitosis; spindle pole IPR020472; IPR026962; IPR028021; IPR015943; IPR001680; IPR019775; IPR017986; Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) katnb1 Xenopus laevis (African clawed frog) TR38494_c0_g1_i6 Q8H0T9 KTNB1_ARATH 9.00E-122 GO:0080008; GO:0008352; GO:0005874; GO:0051013 Cul4-RING ubiquitin ligase complex; katanin complex; microtubule; microtubule severing IPR020472; IPR026962; IPR028021; IPR015943; IPR001680; IPR019775; IPR017986; Katanin p80 WD40 repeat-containing subunit B1 homolog At5g23430 K19M13.6 Arabidopsis thaliana (Mouse-ear cress) TR38496_c0_g1_i1 Q5R8X4 UBA5_PONAB 0 GO:0005524; GO:0071566; GO:0048037; GO:0005737; GO:0046872; GO:0005634; GO:0016616; GO:0071569 "ATP binding; UFM1 activating enzyme activity; cofactor binding; cytoplasm; metal ion binding; nucleus; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein ufmylation" IPR006140; IPR009036; IPR016040; IPR000594; Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) UBA5 UBE1DC1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38496_c0_g1_i2 Q5M7A4 UBA5_RAT 1.00E-178 GO:0005524; GO:0071566; GO:0048037; GO:0005737; GO:0046872; GO:0005634; GO:0016616; GO:0071569 "ATP binding; UFM1 activating enzyme activity; cofactor binding; cytoplasm; metal ion binding; nucleus; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein ufmylation" IPR006140; IPR009036; IPR016040; IPR000594; Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) Uba5 Ube1dc1 Rattus norvegicus (Rat) TR38497_c0_g1_i1 Q86XH1 IQCA1_HUMAN 5.00E-163 GO:0005524 ATP binding IPR003959; IPR000048; IPR027417; IQ and AAA domain-containing protein 1 IQCA1 IQCA Homo sapiens (Human) TR38497_c0_g1_i2 Q6AZT2 SPAST_XENLA 2.00E-19 GO:0005524; GO:0043014; GO:0007409; GO:0048487; GO:0007049; GO:0051301; GO:0005813; GO:0016021; GO:0005874; GO:0008017; GO:0001578; GO:0051013; GO:0008568; GO:0005634; GO:0048471; GO:0031117; GO:0034214; GO:0051260 ATP binding; alpha-tubulin binding; axonogenesis; beta-tubulin binding; cell cycle; cell division; centrosome; integral to membrane; microtubule; microtubule binding; microtubule bundle formation; microtubule severing; microtubule-severing ATPase activity; nucleus; perinuclear region of cytoplasm; positive regulation of microtubule depolymerization; protein hexamerization; protein homooligomerization IPR003593; IPR003959; IPR003960; IPR007330; IPR027417; IPR017179; Spastin (EC 3.6.4.3) spast spg4 Xenopus laevis (African clawed frog) TR38500_c1_g1_i1 O09118 NET1_MOUSE 0 GO:0033564; GO:0006915; GO:0005604; GO:0071944; GO:0016337; GO:0005737; GO:0040023; GO:0042472; GO:0060603; GO:0030517; GO:0001764; GO:0045773; GO:0008284; GO:0030334 anterior/posterior axon guidance; apoptotic process; basement membrane; cell periphery; cell-cell adhesion; cytoplasm; establishment of nucleus localization; inner ear morphogenesis; mammary gland duct morphogenesis; negative regulation of axon extension; neuron migration; positive regulation of axon extension; positive regulation of cell proliferation; regulation of cell migration IPR013032; IPR002049; IPR008979; IPR008211; IPR001134; IPR018933; IPR008993; Netrin-1 Ntn1 Mus musculus (Mouse) TR38500_c1_g2_i1 Q90922 NET1_CHICK 0 GO:0071944; GO:0005578 Q9ERC8 cell periphery; proteinaceous extracellular matrix IPR002049; IPR008979; IPR008211; IPR001134; IPR018933; IPR008993; Netrin-1 NTN1 Gallus gallus (Chicken) TR38502_c4_g2_i1 P49139 MAPK2_RABIT 1.00E-171 GO:0070935; GO:0005524; GO:0031572; GO:0005737; GO:0006954; GO:0044351; GO:0005634; GO:0004674; GO:0032675; GO:0032680; GO:0034097; GO:0032496; GO:0002224 3'-UTR-mediated mRNA stabilization; ATP binding; G2 DNA damage checkpoint; cytoplasm; inflammatory response; macropinocytosis; nucleus; protein serine/threonine kinase activity; regulation of interleukin-6 production; regulation of tumor necrosis factor production; response to cytokine stimulus; response to lipopolysaccharide; toll-like receptor signaling pathway IPR011009; IPR027442; IPR000719; IPR017441; IPR002290; IPR008271; MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) (Fragment) MAPKAPK2 Oryctolagus cuniculus (Rabbit) TR38503_c3_g4_i1 Q8N2E2 VWDE_HUMAN 9.00E-10 GO:0005576 extracellular region IPR000742; IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) TR38505_c1_g2_i1 Q924M5 BOLL_MOUSE 8.00E-07 GO:0003723; GO:0030154; GO:0005737; GO:0007275; GO:0000166; GO:0006417; GO:0007283 RNA binding; cell differentiation; cytoplasm; multicellular organismal development; nucleotide binding; regulation of translation; spermatogenesis IPR012677; IPR000504; Protein boule-like Boll Boule Mus musculus (Mouse) TR38505_c1_g2_i4 Q4R535 CELF4_MACFA 3.00E-68 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0000166; GO:0005634; GO:0048026 "RNA binding; RNA splicing; cytoplasm; mRNA processing; nucleotide binding; nucleus; positive regulation of mRNA splicing, via spliceosome" IPR012677; IPR000504; CUGBP Elav-like family member 4 (CELF-4) (Bruno-like protein 4) (CUG-BP- and ETR-3-like factor 4) (RNA-binding protein BRUNOL-4) CELF4 BRUNOL4 QccE-21315 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38505_c1_g2_i5 Q792H5 CELF2_RAT 3.00E-94 GO:0003723; GO:0005737; GO:0006376; GO:0000166; GO:0005634 RNA binding; cytoplasm; mRNA splice site selection; nucleotide binding; nucleus IPR002343; IPR012677; IPR000504; CUGBP Elav-like family member 2 (CELF-2) (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP2) (CUG-BP- and ETR-3-like factor 2) (ELAV-type RNA-binding protein 3) (ETR-3) (Protein ETR-R3) (Neuroblastoma apoptosis-related RNA-binding protein) (rNapor) (RNA-binding protein BRUNOL-3) Celf2 Cugbp2 Etr3 Napor Rattus norvegicus (Rat) TR38505_c1_g2_i6 Q5NVC8 CELF4_PONAB 3.00E-30 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0000166; GO:0005634; GO:0048026 "RNA binding; RNA splicing; cytoplasm; mRNA processing; nucleotide binding; nucleus; positive regulation of mRNA splicing, via spliceosome" IPR012677; IPR000504; CUGBP Elav-like family member 4 (CELF-4) (Bruno-like protein 4) (CUG-BP- and ETR-3-like factor 4) (RNA-binding protein BRUNOL-4) CELF4 BRUNOL4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38505_c1_g3_i1 A4IIM2 CELF2_XENTR 4.00E-47 GO:0003723; GO:0005737; GO:0006397; GO:0000166; GO:0005634 RNA binding; cytoplasm; mRNA processing; nucleotide binding; nucleus IPR002343; IPR012677; IPR000504; CUGBP Elav-like family member 2 (CELF-2) (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP2) (CUG-BP- and ETR-3-like factor 2) (ELAV-type RNA-binding protein 3) (ETR-3) (RNA-binding protein BRUNOL-3) celf2 brunol3 cugbp2 etr3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38506_c0_g2_i2 Q5U584 3BP5L_XENLA 2.00E-73 IPR007940; SH3 domain-binding protein 5-like (SH3BP-5-like) sh3bp5l Xenopus laevis (African clawed frog) TR38509_c5_g2_i2 Q5REG4 DTX3_PONAB 5.00E-52 GO:0007219; GO:0005737; GO:0016874; GO:0016567; GO:0008270 Notch signaling pathway; cytoplasm; ligase activity; protein ubiquitination; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase DTX3 (EC 6.3.2.-) (Protein deltex-3) (Deltex3) DTX3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38509_c5_g2_i3 Q02874 H2AY_RAT 3.00E-12 GO:0001740; GO:0003677; GO:0003682; GO:0016568; GO:0000793; GO:0007549; GO:0000786; GO:0006334 Barr body; DNA binding; chromatin binding; chromatin modification; condensed chromosome; dosage compensation; nucleosome; nucleosome assembly IPR021171; IPR009072; IPR007125; IPR002119; IPR002589; Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (H2A.y) (H2A/y) H2afy Rattus norvegicus (Rat) TR38509_c5_g2_i4 Q5REG4 DTX3_PONAB 5.00E-52 GO:0007219; GO:0005737; GO:0016874; GO:0016567; GO:0008270 Notch signaling pathway; cytoplasm; ligase activity; protein ubiquitination; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase DTX3 (EC 6.3.2.-) (Protein deltex-3) (Deltex3) DTX3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38509_c5_g2_i6 P0A8D6 YMDB_ECOLI 3.00E-20 GO:0061463; GO:0032074; GO:0060701; GO:0001883; GO:0042278; GO:0006950; GO:0008428 O-acetyl-ADP-ribose deacetylase activity; negative regulation of nuclease activity; negative regulation of ribonuclease activity; purine nucleoside binding; purine nucleoside metabolic process; response to stress; ribonuclease inhibitor activity IPR002589; IPR024900; O-acetyl-ADP-ribose deacetylase (EC 3.5.1.-) (Regulator of RNase III activity) ymdB b1045 JW1032 Escherichia coli (strain K12) TR38509_c5_g2_i7 Q4J9D2 Y1252_SULAC 7.00E-25 IPR002589; Uncharacterized protein Saci_1252 Saci_1252 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) TR38509_c5_g2_i8 Q2EMV9 PAR14_MOUSE 3.00E-23 GO:0003950; GO:0005737; GO:0003676; GO:0005634; GO:0005886; GO:0006355; GO:0006351 P06745 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleic acid binding; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR000504; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) TR38510_c0_g1_i1 Q8R146 APEH_MOUSE 1.00E-95 GO:0005737; GO:0031965; GO:0006508; GO:0004252 cytoplasm; nuclear membrane; proteolysis; serine-type endopeptidase activity IPR002471; IPR001375; IPR015943; Acylamino-acid-releasing enzyme (AARE) (EC 3.4.19.1) (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) Apeh Mus musculus (Mouse) TR38510_c0_g2_i4 P34422 DPF6_CAEEL 6.00E-06 GO:0004177; GO:0016021; GO:0005886; GO:0006508; GO:0008236 aminopeptidase activity; integral to membrane; plasma membrane; proteolysis; serine-type peptidase activity IPR011042; IPR001375; Dipeptidyl peptidase family member 6 (EC 3.4.14.-) dpf-6 F44B9.1 Caenorhabditis elegans TR38510_c0_g4_i3 P39839 YUXL_BACSU 7.00E-14 GO:0006508; GO:0008236 proteolysis; serine-type peptidase activity IPR011042; IPR011659; IPR001375; Uncharacterized peptidase YuxL (EC 3.4.21.-) yuxL BSU32230 Bacillus subtilis (strain 168) TR38512_c0_g1_i1 O60884 DNJA2_HUMAN 7.00E-147 GO:0005524; GO:0016020; GO:0046872; GO:0008284; GO:0006457; GO:0009408 Q9GZX7 ATP binding; membrane; metal ion binding; positive regulation of cell proliferation; protein folding; response to heat IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14) DNAJA2 CPR3 HIRIP4 Homo sapiens (Human) TR38512_c0_g1_i2 O94625 SPJ1_SCHPO 3.00E-46 GO:0030433; GO:0030544; GO:0034620; GO:0005788; GO:0046872; GO:0034975; GO:0015031 ER-associated protein catabolic process; Hsp70 protein binding; cellular response to unfolded protein; endoplasmic reticulum lumen; metal ion binding; protein folding in endoplasmic reticulum; protein transport IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; DnaJ-related protein spj1 spj1 SPBC1347.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38512_c0_g1_i3 Q73IV4 DNAJ_WOLPM 2.00E-21 GO:0005524; GO:0006260; GO:0005737; GO:0006457; GO:0009408; GO:0008270 ATP binding; DNA replication; cytoplasm; protein folding; response to heat; zinc ion binding IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; Chaperone protein DnaJ dnaJ WD_0040 Wolbachia pipientis wMel TR38512_c0_g1_i4 O60884 DNJA2_HUMAN 4.00E-144 GO:0005524; GO:0016020; GO:0046872; GO:0008284; GO:0006457; GO:0009408 Q9GZX7 ATP binding; membrane; metal ion binding; positive regulation of cell proliferation; protein folding; response to heat IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14) DNAJA2 CPR3 HIRIP4 Homo sapiens (Human) TR38514_c13_g1_i1 Q3ZBG9 PLS2_BOVIN 2.00E-28 GO:0016021; GO:0046872 integral to membrane; metal ion binding IPR005552; Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) TR38516_c1_g1_i1 Q9UKR8 TSN16_HUMAN 1.00E-09 GO:0016021 integral to membrane IPR000301; IPR018499; IPR008952; Tetraspanin-16 (Tspan-16) (Tetraspanin TM4-B) (Transmembrane 4 superfamily member 16) TSPAN16 TM4SF16 Homo sapiens (Human) TR38516_c1_g1_i4 Q9UKR8 TSN16_HUMAN 8.00E-10 GO:0016021 integral to membrane IPR000301; IPR018499; IPR008952; Tetraspanin-16 (Tspan-16) (Tetraspanin TM4-B) (Transmembrane 4 superfamily member 16) TSPAN16 TM4SF16 Homo sapiens (Human) TR38516_c1_g1_i5 B5X3I6 TSN9_SALSA 3.00E-06 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-9 (Tspan-9) tspan9 Salmo salar (Atlantic salmon) TR38517_c1_g1_i1 O14744 ANM5_HUMAN 3.00E-148 GO:0008283; GO:0003682; GO:0005829; GO:0042118; GO:0043985; GO:0008469; GO:0034660; GO:0000122; GO:0005634; GO:0043234; GO:0035243; GO:0007088; GO:0043021; GO:0000387; GO:0006351 Q8N8U2; P54105; Q9NQ92; Q01094; Q8TE85; Q9BX10; P62805; Q8WVJ2; Q86U06; O75044; Q96RU7; Q9BQA1; P63104 "cell proliferation; chromatin binding; cytosol; endothelial cell activation; histone H4-R3 methylation; histone-arginine N-methyltransferase activity; ncRNA metabolic process; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein complex; protein-arginine omega-N symmetric methyltransferase activity; regulation of mitosis; ribonucleoprotein complex binding; spliceosomal snRNP assembly; transcription, DNA-dependent" IPR025799; IPR007857; "Protein arginine N-methyltransferase 5 (EC 2.1.1.-) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (EC 2.1.1.125) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]" PRMT5 HRMT1L5 IBP72 JBP1 SKB1 Homo sapiens (Human) TR38517_c1_g2_i2 O14744 ANM5_HUMAN 2.00E-132 GO:0008283; GO:0003682; GO:0005829; GO:0042118; GO:0043985; GO:0008469; GO:0034660; GO:0000122; GO:0005634; GO:0043234; GO:0035243; GO:0007088; GO:0043021; GO:0000387; GO:0006351 Q8N8U2; P54105; Q9NQ92; Q01094; Q8TE85; Q9BX10; P62805; Q8WVJ2; Q86U06; O75044; Q96RU7; Q9BQA1; P63104 "cell proliferation; chromatin binding; cytosol; endothelial cell activation; histone H4-R3 methylation; histone-arginine N-methyltransferase activity; ncRNA metabolic process; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein complex; protein-arginine omega-N symmetric methyltransferase activity; regulation of mitosis; ribonucleoprotein complex binding; spliceosomal snRNP assembly; transcription, DNA-dependent" IPR025799; IPR007857; "Protein arginine N-methyltransferase 5 (EC 2.1.1.-) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (EC 2.1.1.125) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]" PRMT5 HRMT1L5 IBP72 JBP1 SKB1 Homo sapiens (Human) TR38518_c0_g1_i1 P86789 GIGA6_CRAGI 2.00E-51 GO:0016021 integral to membrane IPR001466; IPR012338; Gigasin-6 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) TR38518_c0_g1_i2 Q6G6M9 FLP_STAAS 2.00E-08 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR001466; IPR012338; Protein flp (FmtA-like protein) flp SAS2333 Staphylococcus aureus (strain MSSA476) TR38519_c0_g1_i1 Q8BGQ2 CSRN2_MOUSE 3.00E-61 GO:0001228; GO:0006915; GO:0010923; GO:0005634; GO:0019902; GO:0043565 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; apoptotic process; negative regulation of phosphatase activity; nucleus; phosphatase binding; sequence-specific DNA binding IPR023260; Cysteine/serine-rich nuclear protein 2 (CSRNP-2) (Protein FAM130A1) (TGF-beta-induced apoptosis protein 12) (TAIP-12) Csrnp2 Fam130a1 Taip12 Mus musculus (Mouse) TR38519_c0_g1_i10 Q8BGQ2 CSRN2_MOUSE 3.00E-61 GO:0001228; GO:0006915; GO:0010923; GO:0005634; GO:0019902; GO:0043565 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; apoptotic process; negative regulation of phosphatase activity; nucleus; phosphatase binding; sequence-specific DNA binding IPR023260; Cysteine/serine-rich nuclear protein 2 (CSRNP-2) (Protein FAM130A1) (TGF-beta-induced apoptosis protein 12) (TAIP-12) Csrnp2 Fam130a1 Taip12 Mus musculus (Mouse) TR38519_c0_g1_i3 Q8BGQ2 CSRN2_MOUSE 3.00E-61 GO:0001228; GO:0006915; GO:0010923; GO:0005634; GO:0019902; GO:0043565 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; apoptotic process; negative regulation of phosphatase activity; nucleus; phosphatase binding; sequence-specific DNA binding IPR023260; Cysteine/serine-rich nuclear protein 2 (CSRNP-2) (Protein FAM130A1) (TGF-beta-induced apoptosis protein 12) (TAIP-12) Csrnp2 Fam130a1 Taip12 Mus musculus (Mouse) TR38519_c0_g1_i7 Q8BGQ2 CSRN2_MOUSE 3.00E-61 GO:0001228; GO:0006915; GO:0010923; GO:0005634; GO:0019902; GO:0043565 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; apoptotic process; negative regulation of phosphatase activity; nucleus; phosphatase binding; sequence-specific DNA binding IPR023260; Cysteine/serine-rich nuclear protein 2 (CSRNP-2) (Protein FAM130A1) (TGF-beta-induced apoptosis protein 12) (TAIP-12) Csrnp2 Fam130a1 Taip12 Mus musculus (Mouse) TR38521_c1_g1_i1 O35423 SPYA_MOUSE 7.00E-146 GO:0042853; GO:0019448; GO:0008453; GO:0016597; GO:0019265; GO:0009436; GO:0046487; GO:0005759; GO:0005739; GO:0046724; GO:0005782; GO:0005777; GO:0006625; GO:0030170; GO:0042866; GO:0051591; GO:0051384; GO:0004760 "L-alanine catabolic process; L-cysteine catabolic process; alanine-glyoxylate transaminase activity; amino acid binding; glycine biosynthetic process, by transamination of glyoxylate; glyoxylate catabolic process; glyoxylate metabolic process; mitochondrial matrix; mitochondrion; oxalic acid secretion; peroxisomal matrix; peroxisome; protein targeting to peroxisome; pyridoxal phosphate binding; pyruvate biosynthetic process; response to cAMP; response to glucocorticoid stimulus; serine-pyruvate transaminase activity" IPR000192; IPR020578; IPR015424; IPR015421; IPR015422; IPR024169; "Serine--pyruvate aminotransferase, mitochondrial (SPT) (EC 2.6.1.51) (Alanine--glyoxylate aminotransferase) (AGT) (EC 2.6.1.44)" Agxt Agxt1 Mus musculus (Mouse) TR38521_c1_g1_i3 Q8RLU1 PHNW_BACCE 8.00E-14 GO:0047304; GO:0019700; GO:0030170 2-aminoethylphosphonate-pyruvate transaminase activity; organic phosphonate catabolic process; pyridoxal phosphate binding IPR000192; IPR012703; IPR015424; IPR015421; IPR015422; IPR024169; 2-aminoethylphosphonate--pyruvate transaminase (EC 2.6.1.37) (2-aminoethylphosphonate aminotransferase) (AEP transaminase) (AEPT) (Fragment) phnW Bacillus cereus TR38521_c1_g1_i4 P31029 SPYA_CALJA 1.00E-156 GO:0042853; GO:0019448; GO:0008453; GO:0016597; GO:0019265; GO:0009436; GO:0005759; GO:0046724; GO:0005782; GO:0006625; GO:0030170; GO:0004760 "L-alanine catabolic process; L-cysteine catabolic process; alanine-glyoxylate transaminase activity; amino acid binding; glycine biosynthetic process, by transamination of glyoxylate; glyoxylate catabolic process; mitochondrial matrix; oxalic acid secretion; peroxisomal matrix; protein targeting to peroxisome; pyridoxal phosphate binding; serine-pyruvate transaminase activity" IPR000192; IPR020578; IPR015424; IPR015421; IPR015422; IPR024169; "Serine--pyruvate aminotransferase, mitochondrial (SPT) (EC 2.6.1.51) (Alanine--glyoxylate aminotransferase) (AGT) (EC 2.6.1.44)" AGXT AGT1 Callithrix jacchus (White-tufted-ear marmoset) TR38522_c2_g1_i1 P54120 AIG1_ARATH 3.00E-28 GO:0005525; GO:0009617 GTP binding; response to bacterium IPR006703; IPR027417; Protein AIG1 AIG1 At1g33960 T3M13.2 Arabidopsis thaliana (Mouse-ear cress) TR38522_c2_g1_i2 Q8K3K9 GIMA4_RAT 8.00E-51 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) TR38522_c2_g1_i4 Q6P9H5 GIMA6_HUMAN 7.00E-28 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 6 (Immunity-associated nucleotide 2 protein) (IAN-2) (hIAN2) (Immunity-associated nucleotide 6 protein) (IAN-6) (hIAN6) GIMAP6 IAN2 IAN6 Homo sapiens (Human) TR38522_c2_g1_i6 P54120 AIG1_ARATH 2.00E-28 GO:0005525; GO:0009617 GTP binding; response to bacterium IPR006703; IPR027417; Protein AIG1 AIG1 At1g33960 T3M13.2 Arabidopsis thaliana (Mouse-ear cress) TR38522_c2_g1_i7 Q6P9H5 GIMA6_HUMAN 7.00E-28 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 6 (Immunity-associated nucleotide 2 protein) (IAN-2) (hIAN2) (Immunity-associated nucleotide 6 protein) (IAN-6) (hIAN6) GIMAP6 IAN2 IAN6 Homo sapiens (Human) TR38522_c2_g1_i8 Q8K3K9 GIMA4_RAT 5.00E-51 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) TR38522_c2_g1_i9 Q99JY3 GIMA4_MOUSE 2.00E-44 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Mus musculus (Mouse) TR38523_c2_g2_i1 Q9EQ60 CAC1H_RAT 0 GO:0032342; GO:0070509; GO:0034651; GO:0005737; GO:0030425; GO:0008332; GO:0046872; GO:0005634; GO:0043204; GO:0019233; GO:0005891 aldosterone biosynthetic process; calcium ion import; cortisol biosynthetic process; cytoplasm; dendrite; low voltage-gated calcium channel activity; metal ion binding; nucleus; perikaryon; sensory perception of pain; voltage-gated calcium channel complex IPR027359; IPR005821; IPR005445; Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage-gated calcium channel subunit alpha Cav3.2) Cacna1h Rattus norvegicus (Rat) TR38523_c2_g2_i2 O95180 CAC1H_HUMAN 0 GO:0032342; GO:0007411; GO:0070509; GO:0005901; GO:0032870; GO:0035865; GO:0034651; GO:0008332; GO:0046872; GO:0006936; GO:0007517; GO:0007520; GO:2000344; GO:0008016; GO:0042391; GO:0042383; GO:0005891 aldosterone biosynthetic process; axon guidance; calcium ion import; caveola; cellular response to hormone stimulus; cellular response to potassium ion; cortisol biosynthetic process; low voltage-gated calcium channel activity; metal ion binding; muscle contraction; muscle organ development; myoblast fusion; positive regulation of acrosome reaction; regulation of heart contraction; regulation of membrane potential; sarcolemma; voltage-gated calcium channel complex IPR027359; IPR005821; IPR005445; Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) CACNA1H Homo sapiens (Human) TR38523_c2_g2_i3 O42398 CAC1S_CHICK 1.00E-17 GO:0031674; GO:0030315; GO:0008331; GO:0006936; GO:0005891 I band; T-tubule; high voltage-gated calcium channel activity; muscle contraction; voltage-gated calcium channel complex IPR027359; IPR005821; IPR005450; IPR002077; Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage-gated calcium channel subunit alpha Cav1.1) (Fragment) CACNA1S Gallus gallus (Chicken) TR38523_c2_g2_i4 Q9EQ60 CAC1H_RAT 2.00E-129 GO:0032342; GO:0070509; GO:0034651; GO:0005737; GO:0030425; GO:0008332; GO:0046872; GO:0005634; GO:0043204; GO:0019233; GO:0005891 aldosterone biosynthetic process; calcium ion import; cortisol biosynthetic process; cytoplasm; dendrite; low voltage-gated calcium channel activity; metal ion binding; nucleus; perikaryon; sensory perception of pain; voltage-gated calcium channel complex IPR027359; IPR005821; IPR005445; Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage-gated calcium channel subunit alpha Cav3.2) Cacna1h Rattus norvegicus (Rat) TR38523_c2_g2_i5 O95180 CAC1H_HUMAN 0 GO:0032342; GO:0007411; GO:0070509; GO:0005901; GO:0032870; GO:0035865; GO:0034651; GO:0008332; GO:0046872; GO:0006936; GO:0007517; GO:0007520; GO:2000344; GO:0008016; GO:0042391; GO:0042383; GO:0005891 aldosterone biosynthetic process; axon guidance; calcium ion import; caveola; cellular response to hormone stimulus; cellular response to potassium ion; cortisol biosynthetic process; low voltage-gated calcium channel activity; metal ion binding; muscle contraction; muscle organ development; myoblast fusion; positive regulation of acrosome reaction; regulation of heart contraction; regulation of membrane potential; sarcolemma; voltage-gated calcium channel complex IPR027359; IPR005821; IPR005445; Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) CACNA1H Homo sapiens (Human) TR38523_c2_g2_i6 Q9EQ60 CAC1H_RAT 1.00E-111 GO:0032342; GO:0070509; GO:0034651; GO:0005737; GO:0030425; GO:0008332; GO:0046872; GO:0005634; GO:0043204; GO:0019233; GO:0005891 aldosterone biosynthetic process; calcium ion import; cortisol biosynthetic process; cytoplasm; dendrite; low voltage-gated calcium channel activity; metal ion binding; nucleus; perikaryon; sensory perception of pain; voltage-gated calcium channel complex IPR027359; IPR005821; IPR005445; Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage-gated calcium channel subunit alpha Cav3.2) Cacna1h Rattus norvegicus (Rat) TR38523_c2_g2_i7 O95180 CAC1H_HUMAN 0 GO:0032342; GO:0007411; GO:0070509; GO:0005901; GO:0032870; GO:0035865; GO:0034651; GO:0008332; GO:0046872; GO:0006936; GO:0007517; GO:0007520; GO:2000344; GO:0008016; GO:0042391; GO:0042383; GO:0005891 aldosterone biosynthetic process; axon guidance; calcium ion import; caveola; cellular response to hormone stimulus; cellular response to potassium ion; cortisol biosynthetic process; low voltage-gated calcium channel activity; metal ion binding; muscle contraction; muscle organ development; myoblast fusion; positive regulation of acrosome reaction; regulation of heart contraction; regulation of membrane potential; sarcolemma; voltage-gated calcium channel complex IPR027359; IPR005821; IPR005445; Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) CACNA1H Homo sapiens (Human) TR38523_c2_g3_i1 Q9EQ60 CAC1H_RAT 7.00E-22 GO:0032342; GO:0070509; GO:0034651; GO:0005737; GO:0030425; GO:0008332; GO:0046872; GO:0005634; GO:0043204; GO:0019233; GO:0005891 aldosterone biosynthetic process; calcium ion import; cortisol biosynthetic process; cytoplasm; dendrite; low voltage-gated calcium channel activity; metal ion binding; nucleus; perikaryon; sensory perception of pain; voltage-gated calcium channel complex IPR027359; IPR005821; IPR005445; Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage-gated calcium channel subunit alpha Cav3.2) Cacna1h Rattus norvegicus (Rat) TR38524_c0_g1_i1 Q3SZ71 MPPB_BOVIN 0 GO:0046872; GO:0004222; GO:0005759; GO:0006508 metal ion binding; metalloendopeptidase activity; mitochondrial matrix; proteolysis IPR011249; IPR011237; IPR011765; IPR001431; IPR007863; Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) PMPCB Bos taurus (Bovine) TR38524_c0_g1_i2 P11913 MPPB_NEUCR 3.00E-147 GO:0046872; GO:0004222; GO:0017087; GO:0055114; GO:0006627; GO:0006508; GO:0070469 metal ion binding; metalloendopeptidase activity; mitochondrial processing peptidase complex; oxidation-reduction process; protein processing involved in protein targeting to mitochondrion; proteolysis; respiratory chain IPR011249; IPR011237; IPR011765; IPR001431; IPR007863; Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) (Ubiquinol-cytochrome-c reductase complex core protein I) pep NCU02549 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR38527_c0_g2_i2 Q0IHI1 TXD15_XENLA 3.00E-36 GO:0045454; GO:0016021 cell redox homeostasis; integral to membrane IPR012336; IPR013766; Thioredoxin domain-containing protein 15 txndc15 Xenopus laevis (African clawed frog) TR38528_c1_g1_i2 Q6IDD9 SARM1_DROME 0 GO:0030424; GO:0005737; GO:0045087; GO:0043005; GO:0043025; GO:1901214; GO:0007165 axon; cytoplasm; innate immune response; neuron projection; neuronal cell body; regulation of neuron death; signal transduction IPR011989; IPR016024; IPR001660; IPR013761; IPR011510; IPR000157; Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog) (dSarm) Ect4 dsarm CG43119 Drosophila melanogaster (Fruit fly) TR38528_c1_g1_i6 Q6IDD9 SARM1_DROME 0 GO:0030424; GO:0005737; GO:0045087; GO:0043005; GO:0043025; GO:1901214; GO:0007165 axon; cytoplasm; innate immune response; neuron projection; neuronal cell body; regulation of neuron death; signal transduction IPR011989; IPR016024; IPR001660; IPR013761; IPR011510; IPR000157; Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog) (dSarm) Ect4 dsarm CG43119 Drosophila melanogaster (Fruit fly) TR38529_c1_g1_i2 P50336 PPOX_HUMAN 1.00E-104 GO:0050660; GO:0006783; GO:0031305; GO:0031304; GO:0005758; GO:0004729; GO:0006782; GO:0042493; GO:0044281 flavin adenine dinucleotide binding; heme biosynthetic process; integral to mitochondrial inner membrane; intrinsic to mitochondrial inner membrane; mitochondrial intermembrane space; oxygen-dependent protoporphyrinogen oxidase activity; protoporphyrinogen IX biosynthetic process; response to drug; small molecule metabolic process IPR002937; IPR016040; IPR004572; IPR027418; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1. Protoporphyrinogen oxidase (PPO) (EC 1.3.3.4) PPOX Homo sapiens (Human) TR38535_c1_g1_i1 Q9UL36 ZN236_HUMAN 0 GO:0003677; GO:0071333; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; cellular response to glucose stimulus; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 236 ZNF236 Homo sapiens (Human) TR38535_c2_g2_i1 P20385 CF2_DROME 1.00E-23 GO:0001077; GO:0007527; GO:0046872; GO:0005634; GO:0032968; GO:0043565 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; adult somatic muscle development; metal ion binding; nucleus; positive regulation of transcription elongation from RNA polymerase II promoter; sequence-specific DNA binding IPR007087; IPR015880; IPR013087; Chorion transcription factor Cf2 Cf2 CG11924 Drosophila melanogaster (Fruit fly) TR38535_c2_g2_i2 Q9UL36 ZN236_HUMAN 1.00E-109 GO:0003677; GO:0071333; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; cellular response to glucose stimulus; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 236 ZNF236 Homo sapiens (Human) TR38535_c2_g2_i3 Q8TF68 ZN384_HUMAN 2.00E-24 GO:0005925; GO:0046872; GO:0006913; GO:0005634; GO:0050714; GO:0045944; GO:0043565; GO:0006351 "focal adhesion; metal ion binding; nucleocytoplasmic transport; nucleus; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 384 (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (Trinucleotide repeat-containing gene 1 protein) ZNF384 CAGH1 CIZ NMP4 TNRC1 Homo sapiens (Human) TR38535_c3_g1_i1 Q9ER74 SALL1_MOUSE 1.00E-13 GO:0016581; GO:0001105; GO:0001658; GO:0003682; GO:0042733; GO:0001158; GO:0035136; GO:0000792; GO:0035137; GO:0016575; GO:0031129; GO:0003337; GO:0046872; GO:2000384; GO:2000381; GO:0045879; GO:0000122; GO:0001843; GO:0021889; GO:0021553; GO:0045666; GO:2000177; GO:0072092; GO:0003281 NuRD complex; RNA polymerase II transcription coactivator activity; branching involved in ureteric bud morphogenesis; chromatin binding; embryonic digit morphogenesis; enhancer sequence-specific DNA binding; forelimb morphogenesis; heterochromatin; hindlimb morphogenesis; histone deacetylation; inductive cell-cell signaling; mesenchymal to epithelial transition involved in metanephros morphogenesis; metal ion binding; negative regulation of ectoderm development; negative regulation of mesoderm development; negative regulation of smoothened signaling pathway; negative regulation of transcription from RNA polymerase II promoter; neural tube closure; olfactory bulb interneuron differentiation; olfactory nerve development; positive regulation of neuron differentiation; regulation of neural precursor cell proliferation; ureteric bud invasion; ventricular septum development IPR007087; IPR015880; IPR013087; Sal-like protein 1 (Zinc finger protein Spalt-3) (Sal-3) (mSal-3) Sall1 Sal3 Mus musculus (Mouse) TR38536_c2_g1_i2 Q5R1P0 NMDZ1_CANFA 1.00E-17 GO:0030054; GO:0005234; GO:0016021; GO:0004970; GO:0035235; GO:0014069; GO:0045211 cell junction; extracellular-glutamate-gated ion channel activity; integral to membrane; ionotropic glutamate receptor activity; ionotropic glutamate receptor signaling pathway; postsynaptic density; postsynaptic membrane IPR001828; IPR018882; IPR019594; IPR001320; IPR001508; IPR028082; IPR001638; "Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor 1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)" GRIN1 NMDAR1 Canis familiaris (Dog) (Canis lupus familiaris) TR38536_c2_g2_i1 B4GF83 NMDA1_DROPE 0 GO:0017146; GO:0055074; GO:0030054; GO:0005234; GO:0004970; GO:0007616; GO:0008355; GO:0014069; GO:0045211; GO:0042391; GO:0007268 N-methyl-D-aspartate selective glutamate receptor complex; calcium ion homeostasis; cell junction; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; long-term memory; olfactory learning; postsynaptic density; postsynaptic membrane; regulation of membrane potential; synaptic transmission IPR001828; IPR018882; IPR019594; IPR001320; IPR001508; IPR028082; IPR001638; Glutamate [NMDA] receptor subunit 1 Nmdar1 GL22160 Drosophila persimilis (Fruit fly) TR38536_c2_g2_i2 B4GF83 NMDA1_DROPE 0 GO:0017146; GO:0055074; GO:0030054; GO:0005234; GO:0004970; GO:0007616; GO:0008355; GO:0014069; GO:0045211; GO:0042391; GO:0007268 N-methyl-D-aspartate selective glutamate receptor complex; calcium ion homeostasis; cell junction; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; long-term memory; olfactory learning; postsynaptic density; postsynaptic membrane; regulation of membrane potential; synaptic transmission IPR001828; IPR018882; IPR019594; IPR001320; IPR001508; IPR028082; IPR001638; Glutamate [NMDA] receptor subunit 1 Nmdar1 GL22160 Drosophila persimilis (Fruit fly) TR38537_c1_g1_i1 P79385 MFGM_PIG 8.00E-47 GO:0002080; GO:0001525; GO:0007155; GO:0005576; GO:0007338 acrosomal membrane; angiogenesis; cell adhesion; extracellular region; single fertilization IPR000421; IPR000742; IPR013032; IPR008979; IPR027060; Lactadherin (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) (Sperm surface protein SP47) (PP47) MFGE8 Sus scrofa (Pig) TR38537_c1_g1_i2 Q9Z1L4 XLRS1_MOUSE 1.00E-21 GO:0016062; GO:0007155; GO:0005576; GO:0019897; GO:0005547; GO:0043325; GO:0080025; GO:0032266; GO:0005546; GO:0070273; GO:0010314; GO:0001786; GO:0010842 "adaptation of rhodopsin mediated signaling; cell adhesion; extracellular region; extrinsic to plasma membrane; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; phosphatidylserine binding; retina layer formation" IPR000421; IPR008979; Retinoschisin (X-linked juvenile retinoschisis protein homolog) Rs1 Rs1h Xlrs1 Mus musculus (Mouse) TR38537_c1_g1_i3 P79385 MFGM_PIG 5.00E-35 GO:0002080; GO:0001525; GO:0007155; GO:0005576; GO:0007338 acrosomal membrane; angiogenesis; cell adhesion; extracellular region; single fertilization IPR000421; IPR000742; IPR013032; IPR008979; IPR027060; Lactadherin (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) (Sperm surface protein SP47) (PP47) MFGE8 Sus scrofa (Pig) TR38538_c7_g1_i1 Q58DT4 P5CR1_BOVIN 4.00E-70 GO:0055129; GO:0034599; GO:0005739; GO:0006561; GO:0004735 L-proline biosynthetic process; cellular response to oxidative stress; mitochondrion; proline biosynthetic process; pyrroline-5-carboxylate reductase activity IPR008927; IPR016040; IPR000304; Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. "Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2)" PYCR1 Bos taurus (Bovine) TR38538_c7_g1_i3 O04016 P5CR_ACTCH 4.00E-63 GO:0055129; GO:0005737; GO:0004735 L-proline biosynthetic process; cytoplasm; pyrroline-5-carboxylate reductase activity IPR008927; IPR016040; IPR000304; Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. Pyrroline-5-carboxylate reductase (P5C reductase) (P5CR) (EC 1.5.1.2) Actinidia chinensis (Kiwi) (Yangtao) TR38540_c1_g4_i2 A1C2U3 GDF8_PONPY 3.00E-54 GO:0005615; GO:0040007; GO:0008201 extracellular space; growth; heparin binding IPR015616; IPR001839; IPR001111; IPR015615; IPR017948; Growth/differentiation factor 8 (GDF-8) (Myostatin) MSTN GDF8 Pongo pygmaeus (Bornean orangutan) TR38541_c3_g3_i10 Q5PQ71 ISOC2_XENLA 9.00E-84 GO:0003824; GO:0005739 catalytic activity; mitochondrion IPR000868; "Isochorismatase domain-containing protein 2, mitochondrial" isoc2 Xenopus laevis (African clawed frog) TR38541_c3_g3_i13 Q08C33 ISOC1_DANRE 3.00E-69 GO:0003824 catalytic activity IPR000868; Isochorismatase domain-containing protein 1 isoc1 zgc:153699 Danio rerio (Zebrafish) (Brachydanio rerio) TR38541_c3_g3_i5 Q4R826 ISOC2_MACFA 1.00E-71 GO:0003824; GO:0005739; GO:0005634 catalytic activity; mitochondrion; nucleus IPR000868; "Isochorismatase domain-containing protein 2, mitochondrial" ISOC2 QtsA-13690 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38541_c3_g3_i6 Q5PQ71 ISOC2_XENLA 4.00E-87 GO:0003824; GO:0005739 catalytic activity; mitochondrion IPR000868; "Isochorismatase domain-containing protein 2, mitochondrial" isoc2 Xenopus laevis (African clawed frog) TR38541_c3_g3_i8 P21367 YCAC_ECOLI 1.00E-07 GO:0005829; GO:0016787; GO:0016020 cytosol; hydrolase activity; membrane IPR000868; Uncharacterized protein YcaC ycaC b0897 JW0880 Escherichia coli (strain K12) TR38541_c3_g3_i9 A0JME6 ISOC2_DANRE 7.00E-63 GO:0003824; GO:0005739 catalytic activity; mitochondrion IPR000868; "Isochorismatase domain-containing protein 2, mitochondrial" isoc2 zgc:109735 Danio rerio (Zebrafish) (Brachydanio rerio) TR38542_c0_g1_i2 Q9TVL3 CDK9_CAEEL 3.00E-119 GO:0005524; GO:0008353; GO:0005694; GO:0004693; GO:0005634; GO:0006355; GO:0006351 "ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; chromosome; cyclin-dependent protein serine/threonine kinase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Probable cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 9) cdk-9 H25P06.2 Caenorhabditis elegans TR38542_c0_g1_i3 P50750 CDK9_HUMAN 0 GO:0005524; GO:0003677; GO:0006281; GO:0016605; GO:0008353; GO:0008283; GO:0071345; GO:0003682; GO:0004693; GO:0005737; GO:0071157; GO:0045944; GO:0050434; GO:0008024; GO:0006282; GO:0031056; GO:0043111; GO:0017069; GO:0006368; GO:0006367; GO:0044212; GO:0007179; GO:0016032 Q13535; Q8WXE1; O60563; Q9HAW4; Q7L2E3; O94992; P08238; Q4G0J3; Q9Y5X4; P04608 ATP binding; DNA binding; DNA repair; PML body; RNA polymerase II carboxy-terminal domain kinase activity; cell proliferation; cellular response to cytokine stimulus; chromatin binding; cyclin-dependent protein serine/threonine kinase activity; cytoplasm; negative regulation of cell cycle arrest; positive regulation of transcription from RNA polymerase II promoter; positive regulation of viral transcription; positive transcription elongation factor complex b; regulation of DNA repair; regulation of histone modification; replication fork arrest; snRNA binding; transcription elongation from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription regulatory region DNA binding; transforming growth factor beta receptor signaling pathway; viral process IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit) CDK9 CDC2L4 TAK Homo sapiens (Human) TR38543_c2_g1_i1 P57999 ZAN_RABIT 1.00E-42 GO:0007155; GO:0016021; GO:0005886 cell adhesion; integral to membrane; plasma membrane IPR008985; IPR000742; IPR013032; IPR000998; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; Zonadhesin (Fragment) ZAN Oryctolagus cuniculus (Rabbit) TR38543_c2_g1_i2 P57999 ZAN_RABIT 1.00E-42 GO:0007155; GO:0016021; GO:0005886 cell adhesion; integral to membrane; plasma membrane IPR008985; IPR000742; IPR013032; IPR000998; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; Zonadhesin (Fragment) ZAN Oryctolagus cuniculus (Rabbit) TR38544_c1_g3_i1 Q7SY75 NCALD_XENLA 6.00E-29 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Neurocalcin-delta ncald Xenopus laevis (African clawed frog) TR38544_c1_g3_i2 Q54LX0 CBPM_DICDI 2.00E-19 GO:0005509; GO:0045335 calcium ion binding; phagocytic vesicle IPR011992; IPR018247; IPR002048; IPR001125; Calcium-binding protein M cbpM DDB_G0286371 Dictyostelium discoideum (Slime mold) TR38544_c1_g3_i4 Q55G87 CANB1_DICDI 2.00E-06 GO:0005955; GO:0005509; GO:0031287; GO:0006470; GO:0043157 calcineurin complex; calcium ion binding; positive regulation of sorocarp stalk cell differentiation; protein dephosphorylation; response to cation stress IPR011992; IPR018247; IPR002048; IPR001125; Calcineurin subunit B type 1 (Calcineurin regulatory subunit 1) (Protein phosphatase 2B regulatory subunit 1) cnbA DDB_G0267446 Dictyostelium discoideum (Slime mold) TR38545_c3_g1_i1 A5PJ65 RER1_BOVIN 6.00E-87 GO:0030173; GO:0006890 "integral to Golgi membrane; retrograde vesicle-mediated transport, Golgi to ER" IPR004932; Protein RER1 RER1 Bos taurus (Bovine) TR38545_c3_g1_i3 A5PJ65 RER1_BOVIN 2.00E-89 GO:0030173; GO:0006890 "integral to Golgi membrane; retrograde vesicle-mediated transport, Golgi to ER" IPR004932; Protein RER1 RER1 Bos taurus (Bovine) TR38545_c3_g2_i3 Q54D10 RER1_DICDI 5.00E-45 GO:0016021; GO:0015031 integral to membrane; protein transport IPR004932; Protein RER1 homolog rer1 DDB_G0292588 Dictyostelium discoideum (Slime mold) TR38545_c3_g2_i5 Q5R5U4 RER1_PONAB 8.00E-50 GO:0000139; GO:0016021 Golgi membrane; integral to membrane IPR004932; Protein RER1 RER1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38548_c0_g1_i1 Q6UPE0 CHDH_RAT 4.00E-20 GO:0008812; GO:0050660; GO:0019285; GO:0005743 choline dehydrogenase activity; flavin adenine dinucleotide binding; glycine betaine biosynthetic process from choline; mitochondrial inner membrane IPR012132; IPR000172; IPR007867; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. "Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)" Chdh Rattus norvegicus (Rat) TR38548_c0_g2_i1 P18172 DHGL_DROPS 9.00E-29 GO:0006066; GO:0008812; GO:0005576; GO:0050660 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR38548_c1_g1_i1 O14353 BPL1_SCHPO 7.00E-35 GO:0005524; GO:0004077; GO:0004078; GO:0004079; GO:0004080; GO:0005737; GO:0009305 ATP binding; biotin-[acetyl-CoA-carboxylase] ligase activity; biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity; biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity; biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity; cytoplasm; protein biotinylation IPR019197; IPR004408; IPR003142; IPR004143; Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] bpl1 SPBC30D10.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38548_c1_g1_i2 P48445 BPL1_YEAST 2.00E-30 GO:0005524; GO:0004077; GO:0004078; GO:0004079; GO:0004080; GO:0071734; GO:0005737; GO:0009305 ATP binding; biotin-[acetyl-CoA-carboxylase] ligase activity; biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity; biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity; biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity; biotin-[pyruvate-carboxylase] ligase activity; cytoplasm; protein biotinylation IPR019197; IPR004408; IPR003142; IPR004143; Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] BPL1 ACC2 YDL141W D2140 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR38548_c3_g2_i4 P86853 MYT1_MYTGA 4.00E-33 GO:0005576 extracellular region Mytilin-1 (Mytilus uncharacterized protein 1) (MUSP-1) (Fragment) Mytilus galloprovincialis (Mediterranean mussel) TR38548_c3_g4_i1 Q9UTM0 YIV2_SCHPO 5.00E-09 GO:0003677; GO:0006281; GO:0031011; GO:0016568; GO:0005829; GO:0046872; GO:0006357; GO:0006351 "DNA binding; DNA repair; Ino80 complex; chromatin modification; cytosol; metal ion binding; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; INO80 complex subunit 1 iec1 SPAC144.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38548_c3_g4_i2 O08876 KLF10_RAT 7.00E-44 GO:0003677; GO:0030282; GO:1901653; GO:0046872; GO:0005634; GO:0045672; GO:0006355; GO:0035019; GO:0006351 "DNA binding; bone mineralization; cellular response to peptide; metal ion binding; nucleus; positive regulation of osteoclast differentiation; regulation of transcription, DNA-dependent; somatic stem cell maintenance; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Krueppel-like factor 10 (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) (Zinc finger transcription factor homolog CPG20) Klf10 Cpg20 Tieg Tieg1 Rattus norvegicus (Rat) TR38550_c0_g1_i1 Q24251 ATP5H_DROME 7.00E-17 GO:0015986; GO:0015078; GO:0005811; GO:0005875; GO:0000276; GO:0005739 "ATP synthesis coupled proton transport; hydrogen ion transmembrane transporter activity; lipid particle; microtubule associated complex; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); mitochondrion" IPR008689; "ATP synthase subunit d, mitochondrial (ATPase subunit d)" ATPsyn-d CG6030 Drosophila melanogaster (Fruit fly) TR38551_c0_g1_i1 Q91175 ADA1A_ORYLA 7.00E-23 GO:0004935; GO:0071875; GO:0016021; GO:0005886 adrenergic receptor activity; adrenergic receptor signaling pathway; integral to membrane; plasma membrane IPR002233; IPR000276; IPR017452; Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (MAR1) adra1a Oryzias latipes (Medaka fish) (Japanese ricefish) TR38551_c0_g1_i2 Q28558 MTR1L_SHEEP 8.00E-17 GO:0016021; GO:0008502; GO:0005886 integral to membrane; melatonin receptor activity; plasma membrane IPR000276; IPR017452; IPR002280; IPR000025; Melatonin-related receptor (G protein-coupled receptor 50) (H9) GPR50 Ovis aries (Sheep) TR38551_c0_g1_i3 P51049 MR1BB_DANRE 2.00E-13 GO:0016021; GO:0008502; GO:0005886; GO:0048511 integral to membrane; melatonin receptor activity; plasma membrane; rhythmic process IPR000276; IPR017452; IPR002278; IPR027459; IPR000025; Melatonin receptor type 1B-B (Mel-1B-R-B) (Mel1b receptor B) (Melatonin receptor Mel1b Z2.6-4) (zMel1b-1) mtnr1bb mel1br mtnr1br mtnr1br-2 si:ch211-214k5.4 si:ch211-224h1.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR38551_c0_g1_i4 Q9EP86 NPFF1_RAT 4.00E-12 GO:0016021; GO:0008188; GO:0007218; GO:0005886 integral to membrane; neuropeptide receptor activity; neuropeptide signaling pathway; plasma membrane IPR000276; IPR017452; IPR005395; IPR005396; Neuropeptide FF receptor 1 (G-protein coupled receptor 147) (RFamide-related peptide receptor OT7T022) Npffr1 Gpr147 Npff1 Rattus norvegicus (Rat) TR38552_c1_g1_i1 Q6P0C6 LHPL2_DANRE 6.00E-53 GO:0016021 integral to membrane IPR019372; Lipoma HMGIC fusion partner-like 2 protein lhfpl2 zgc:77456 Danio rerio (Zebrafish) (Brachydanio rerio) TR38552_c1_g1_i3 Q5PPI7 TMHS_RAT 8.00E-09 GO:0016324; GO:0060088; GO:0050910; GO:0016021; GO:0006811; GO:0032426 apical plasma membrane; auditory receptor cell stereocilium organization; detection of mechanical stimulus involved in sensory perception of sound; integral to membrane; ion transport; stereocilium bundle tip IPR019372; Tetraspan membrane protein of hair cell stereocilia (Lipoma HMGIC fusion partner-like 5 protein) Lhfpl5 Tmhs Rattus norvegicus (Rat) TR38554_c1_g1_i2 Q5XXA7 HDGR2_DANRE 2.00E-08 IPR021567; IPR000313; Hepatoma-derived growth factor-related protein 2 (HRP-2) hdgfrp2 si:ch211-232a14.3 zgc:66215 Danio rerio (Zebrafish) (Brachydanio rerio) TR38554_c1_g1_i4 Q32N87 HDGR2_XENLA 3.00E-08 GO:0003677 DNA binding IPR017956; IPR021567; IPR000313; Hepatoma-derived growth factor-related protein 2 (HRP-2) hdgfrp2 Xenopus laevis (African clawed frog) TR38555_c2_g3_i1 Q02978 M2OM_HUMAN 2.00E-139 GO:0006094; GO:0005887; GO:0005743; GO:0015367; GO:0044281 gluconeogenesis; integral to plasma membrane; mitochondrial inner membrane; oxoglutarate:malate antiporter activity; small molecule metabolic process IPR018108; IPR023395; Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute carrier family 25 member 11) SLC25A11 SLC20A4 Homo sapiens (Human) TR38555_c2_g3_i2 Q9UBX3 DIC_HUMAN 5.00E-52 GO:0015297; GO:0034641; GO:0005310; GO:0006094; GO:0016021; GO:0015140; GO:0005743; GO:0006839; GO:0005634; GO:0015114; GO:0015141; GO:0015116; GO:0008272; GO:0070221; GO:0000098; GO:0015117; GO:0015709 Q99750 "antiporter activity; cellular nitrogen compound metabolic process; dicarboxylic acid transmembrane transporter activity; gluconeogenesis; integral to membrane; malate transmembrane transporter activity; mitochondrial inner membrane; mitochondrial transport; nucleus; phosphate ion transmembrane transporter activity; succinate transmembrane transporter activity; sulfate transmembrane transporter activity; sulfate transport; sulfide oxidation, using sulfide:quinone oxidoreductase; sulfur amino acid catabolic process; thiosulfate transmembrane transporter activity; thiosulfate transport" IPR002030; IPR018108; IPR023395; Mitochondrial dicarboxylate carrier (Solute carrier family 25 member 10) SLC25A10 DIC Homo sapiens (Human) TR38555_c2_g3_i3 Q02978 M2OM_HUMAN 1.00E-139 GO:0006094; GO:0005887; GO:0005743; GO:0015367; GO:0044281 gluconeogenesis; integral to plasma membrane; mitochondrial inner membrane; oxoglutarate:malate antiporter activity; small molecule metabolic process IPR018108; IPR023395; Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute carrier family 25 member 11) SLC25A11 SLC20A4 Homo sapiens (Human) TR38557_c0_g1_i3 Q6FG11 ANMK_ACIAD 2.00E-34 GO:0097175; GO:0005524; GO:0006040; GO:0005975; GO:0016301; GO:0009254; GO:0016773 "1,6-anhydro-N-acetyl-beta-muramic acid catabolic process; ATP binding; amino sugar metabolic process; carbohydrate metabolic process; kinase activity; peptidoglycan turnover; phosphotransferase activity, alcohol group as acceptor" IPR005338; "Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. Cell wall biogenesis; peptidoglycan recycling." Anhydro-N-acetylmuramic acid kinase (EC 2.7.1.170) (AnhMurNAc kinase) anmK ACIAD0011 Acinetobacter sp. (strain ADP1) TR38558_c1_g2_i1 Q96AN5 TM143_HUMAN 5.00E-49 GO:0016021; GO:0005739 integral to membrane; mitochondrion IPR022227; Transmembrane protein 143 TMEM143 UNQ5922/PRO19813 Homo sapiens (Human) TR38558_c1_g2_i3 Q96AN5 TM143_HUMAN 2.00E-48 GO:0016021; GO:0005739 integral to membrane; mitochondrion IPR022227; Transmembrane protein 143 TMEM143 UNQ5922/PRO19813 Homo sapiens (Human) TR38560_c3_g1_i2 Q7KNF2 PABP2_DROME 5.00E-61 GO:0071013; GO:0005737; GO:0006378; GO:0000398; GO:0022008; GO:0000289; GO:0000166; GO:0008143; GO:0071011 "catalytic step 2 spliceosome; cytoplasm; mRNA polyadenylation; mRNA splicing, via spliceosome; neurogenesis; nuclear-transcribed mRNA poly(A) tail shortening; nucleotide binding; poly(A) RNA binding; precatalytic spliceosome" IPR012677; IPR000504; Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (dPABP2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) (Protein rox2) Pabp2 rox2 CG2163 Drosophila melanogaster (Fruit fly) TR38563_c0_g1_i2 Q00004 SRP68_CANFA 1.00E-106 GO:0008312; GO:0006614; GO:0005829; GO:0030942; GO:0005730; GO:0042493; GO:0005047; GO:0005786 "7S RNA binding; SRP-dependent cotranslational protein targeting to membrane; cytosol; endoplasmic reticulum signal peptide binding; nucleolus; response to drug; signal recognition particle binding; signal recognition particle, endoplasmic reticulum targeting" IPR026258; Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein) SRP68 Canis familiaris (Dog) (Canis lupus familiaris) TR38564_c0_g1_i1 Q3SZJ4 PTGR1_BOVIN 7.00E-101 GO:0036132; GO:0047522; GO:0032440; GO:0005737; GO:0006693; GO:0008270 13-prostaglandin reductase activity; 15-oxoprostaglandin 13-oxidase activity; 2-alkenal reductase [NAD(P)] activity; cytoplasm; prostaglandin metabolic process; zinc ion binding IPR013149; IPR002085; IPR014190; IPR011032; IPR016040; Prostaglandin reductase 1 (PRG-1) (EC 1.3.1.-) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (NADP-dependent leukotriene B4 12-hydroxydehydrogenase) (EC 1.3.1.74) PTGR1 LTB4DH Bos taurus (Bovine) TR38564_c0_g1_i2 O34812 YFMJ_BACSU 3.00E-67 GO:0019439; GO:0016491; GO:0009636; GO:0008270 aromatic compound catabolic process; oxidoreductase activity; response to toxic substance; zinc ion binding IPR013149; IPR002085; IPR011032; IPR016040; Putative NADP-dependent oxidoreductase YfmJ (EC 1.-.-.-) yfmJ BSU07450 Bacillus subtilis (strain 168) TR38564_c0_g1_i3 Q9C0Y6 YKM8_SCHPO 1.00E-48 GO:0005829; GO:0005634; GO:0016491; GO:0008270 cytosol; nucleus; oxidoreductase activity; zinc ion binding IPR013149; IPR002085; IPR011032; IPR016040; Zinc-type alcohol dehydrogenase-like protein PB24D3.08c (EC 1.-.-.-) SPAPB24D3.08c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38564_c0_g1_i4 Q3SZJ4 PTGR1_BOVIN 6.00E-106 GO:0036132; GO:0047522; GO:0032440; GO:0005737; GO:0006693; GO:0008270 13-prostaglandin reductase activity; 15-oxoprostaglandin 13-oxidase activity; 2-alkenal reductase [NAD(P)] activity; cytoplasm; prostaglandin metabolic process; zinc ion binding IPR013149; IPR002085; IPR014190; IPR011032; IPR016040; Prostaglandin reductase 1 (PRG-1) (EC 1.3.1.-) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (NADP-dependent leukotriene B4 12-hydroxydehydrogenase) (EC 1.3.1.74) PTGR1 LTB4DH Bos taurus (Bovine) TR38566_c1_g1_i1 D3YZP9 CCDC6_MOUSE 1.00E-121 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR019152; Coiled-coil domain-containing protein 6 Ccdc6 Mus musculus (Mouse) TR38567_c1_g1_i1 Q9VEC3 ARP5_DROME 6.00E-121 GO:0006310; GO:0006281; GO:0031011; GO:0006338; GO:0006355; GO:0006351 "DNA recombination; DNA repair; Ino80 complex; chromatin remodeling; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR004000; IPR027664; Actin-related protein 5 Arp5 CG7940 Drosophila melanogaster (Fruit fly) TR38567_c1_g1_i2 Q8LGE3 ARP6_ARATH 1.00E-14 GO:0030029; GO:0008283; GO:0006338; GO:0005737; GO:0005856; GO:0006952; GO:0007275; GO:0009910; GO:0005634; GO:0006355; GO:0009266; GO:0005200 Q7X9V2; Q9FHW2 "actin filament-based process; cell proliferation; chromatin remodeling; cytoplasm; cytoskeleton; defense response; multicellular organismal development; negative regulation of flower development; nucleus; regulation of transcription, DNA-dependent; response to temperature stimulus; structural constituent of cytoskeleton" IPR004000; Actin-related protein 6 (Protein EARLY IN SHORT DAYS 1) (Protein SUPPRESSOR OF FRIGIDA 3) ARP6 ESD1 SUF3 At3g33520 T4P3.8 Arabidopsis thaliana (Mouse-ear cress) TR38568_c3_g1_i2 A2AX52 CO6A4_MOUSE 3.00E-36 GO:0007155; GO:0005581; GO:0005576; GO:0043234; GO:0070208 cell adhesion; collagen; extracellular region; protein complex; protein heterotrimerization IPR008160; IPR002035; Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) TR38568_c3_g1_i3 O42163 COCH_CHICK 1.00E-13 GO:0005576; GO:0008360; GO:0007605 extracellular region; regulation of cell shape; sensory perception of sound IPR004043; IPR002035; Cochlin (COCH-5B2) COCH COCH5B2 Gallus gallus (Chicken) TR38569_c1_g1_i1 P24346 DDX3_XENLA 0 GO:0005524; GO:0008026; GO:0003723 ATP binding; ATP-dependent helicase activity; RNA binding IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Putative ATP-dependent RNA helicase an3 (EC 3.6.4.13) an3 Xenopus laevis (African clawed frog) TR38569_c1_g1_i2 P24346 DDX3_XENLA 0 GO:0005524; GO:0008026; GO:0003723 ATP binding; ATP-dependent helicase activity; RNA binding IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Putative ATP-dependent RNA helicase an3 (EC 3.6.4.13) an3 Xenopus laevis (African clawed frog) TR38573_c0_g2_i2 Q502L2 PGAM5_DANRE 8.00E-91 GO:0016021; GO:0005741; GO:0004721 integral to membrane; mitochondrial outer membrane; phosphoprotein phosphatase activity IPR013078; "Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Phosphoglycerate mutase family member 5)" pgam5 si:dkey-69p22.1 zgc:92057 Danio rerio (Zebrafish) (Brachydanio rerio) TR38573_c0_g2_i4 Q5FWM4 PGAM5_XENLA 1.00E-90 GO:0016021; GO:0005741; GO:0004721 integral to membrane; mitochondrial outer membrane; phosphoprotein phosphatase activity IPR013078; "Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Phosphoglycerate mutase family member 5)" pgam5 Xenopus laevis (African clawed frog) TR38576_c3_g2_i1 Q6ZSB9 ZBT49_HUMAN 7.00E-17 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR020542; IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) ZBTB49 ZNF509 Homo sapiens (Human) TR38576_c3_g2_i2 Q6P560 ZN182_MOUSE 8.00E-20 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 182 (Zinc finger protein 21) Znf182 Zfp182 Znf21 Mus musculus (Mouse) TR38576_c3_g2_i3 Q9Y2X9 ZN281_HUMAN 3.00E-08 GO:0001047; GO:0010172; GO:0046872; GO:0045892; GO:0005634; GO:0045893; GO:0043565; GO:0003700; GO:0048863; GO:0003714; GO:0006351 "core promoter binding; embryonic body morphogenesis; metal ion binding; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; stem cell differentiation; transcription corepressor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) ZNF281 GZP1 ZBP99 Homo sapiens (Human) TR38577_c0_g1_i3 Q2UG43 SEC13_ASPOR 6.00E-07 GO:0030127; GO:0005789; GO:0051028; GO:0005643; GO:0015031; GO:0016192 COPII vesicle coat; endoplasmic reticulum membrane; mRNA transport; nuclear pore; protein transport; vesicle-mediated transport IPR020472; IPR015943; IPR001680; IPR017986; Protein transport protein sec13 sec13 AO090023000986 Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) TR38577_c0_g1_i5 Q8NFH4 NUP37_HUMAN 9.00E-62 GO:0005975; GO:0051301; GO:0007059; GO:0000777; GO:0019221; GO:0005829; GO:0015758; GO:0051028; GO:0007067; GO:0007077; GO:0031080; GO:0015031; GO:0010827; GO:0044281; GO:0055085; GO:0016032 carbohydrate metabolic process; cell division; chromosome segregation; condensed chromosome kinetochore; cytokine-mediated signaling pathway; cytosol; glucose transport; mRNA transport; mitosis; mitotic nuclear envelope disassembly; nuclear pore outer ring; protein transport; regulation of glucose transport; small molecule metabolic process; transmembrane transport; viral process IPR015943; IPR001680; IPR019775; IPR017986; Nucleoporin Nup37 (p37) (Nup107-160 subcomplex subunit Nup37) NUP37 Homo sapiens (Human) TR3858_c0_g1_i1 Q5F3T7 CELF1_CHICK 8.00E-06 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0000166; GO:0005634 RNA binding; RNA splicing; cytoplasm; mRNA processing; nucleotide binding; nucleus IPR012677; IPR000504; CUGBP Elav-like family member 1 (CELF-1) (Bruno-like protein 2) (CUG triplet repeat RNA-binding protein 1) (CUG-BP1) (CUG-BP- and ETR-3-like factor 1) (RNA-binding protein BRUNOL-2) CELF1 BRUL CUGBP1 RCJMB04_7f23 Gallus gallus (Chicken) TR38580_c0_g2_i1 O43663 PRC1_HUMAN 5.00E-07 GO:0000910; GO:0005737; GO:0000022; GO:0005634; GO:0005886; GO:0005876; GO:0000922 O94972 cytokinesis; cytoplasm; mitotic spindle elongation; nucleus; plasma membrane; spindle microtubule; spindle pole IPR007145; Protein regulator of cytokinesis 1 PRC1 Homo sapiens (Human) TR38580_c3_g1_i1 Q5R9Z1 VPS29_PONAB 2.00E-116 GO:0010008; GO:0046872; GO:0004647; GO:0015031 endosome membrane; metal ion binding; phosphoserine phosphatase activity; protein transport IPR024654; IPR000979; Vacuolar protein sorting-associated protein 29 (EC 3.1.3.3) (Vesicle protein sorting 29) VPS29 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38581_c1_g1_i1 Q12UG7 RADA_METBU 2.00E-47 GO:0005524; GO:0006310; GO:0006281; GO:0008094; GO:0003684 ATP binding; DNA recombination; DNA repair; DNA-dependent ATPase activity; damaged DNA binding IPR003593; IPR013632; IPR011938; IPR016467; IPR020588; IPR010995; IPR003583; IPR027417; IPR020587; DNA repair and recombination protein RadA radA Mbur_2033 Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) TR38581_c1_g1_i3 Q91918 RA51A_XENLA 2.00E-123 GO:0005524; GO:0006281; GO:0008094; GO:0003684; GO:0000228 ATP binding; DNA repair; DNA-dependent ATPase activity; damaged DNA binding; nuclear chromosome IPR003593; IPR011941; IPR013632; IPR016467; IPR020588; IPR010995; IPR003583; IPR027417; IPR020587; DNA repair protein RAD51 homolog A (xRAD51.1) rad51-a rad51-1 rad51.1 Xenopus laevis (African clawed frog) TR38581_c1_g1_i4 Q14565 DMC1_HUMAN 2.00E-66 GO:0005524; GO:0003677; GO:0008094; GO:0000781; GO:0000794; GO:0007292; GO:0007141; GO:0001556; GO:0001541; GO:0007131; GO:0007286; GO:0007283; GO:0007129 P51587 "ATP binding; DNA binding; DNA-dependent ATPase activity; chromosome, telomeric region; condensed nuclear chromosome; female gamete generation; male meiosis I; oocyte maturation; ovarian follicle development; reciprocal meiotic recombination; spermatid development; spermatogenesis; synapsis" IPR003593; IPR011940; IPR013632; IPR016467; IPR020588; IPR010995; IPR027417; IPR020587; Meiotic recombination protein DMC1/LIM15 homolog DMC1 DMC1H LIM15 Homo sapiens (Human) TR38581_c1_g2_i1 P25301 RAD57_YEAST 2.00E-06 GO:0005524; GO:0003677; GO:0008094; GO:0033062; GO:0030491; GO:0000707; GO:0000722 Q06032; P38953 ATP binding; DNA binding; DNA-dependent ATPase activity; Rhp55-Rhp57 complex; heteroduplex formation; meiotic DNA recombinase assembly; telomere maintenance via recombination IPR003593; IPR013632; IPR020588; IPR027417; DNA repair protein RAD57 RAD57 YDR004W YD8119.10 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR38583_c1_g3_i3 Q91DM0 POLG_PVCV1 7.00E-07 GO:0003677; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508; GO:0046740; GO:0006810; GO:0008270 "DNA binding; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis; spread of virus in host, cell to cell; transport; zinc ion binding" IPR000477; IPR001878; Genome polyprotein [Cleaved into: Movement protein (MP); Capsid protein (CP); Aspartic protease (PR) (EC 3.4.23.-); Reverse transcriptase (RT) (EC 2.7.7.49)] Petunia vein clearing virus (isolate Shepherd) (PVCV) TR38583_c1_g3_i6 Q91DM0 POLG_PVCV1 9.00E-07 GO:0003677; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508; GO:0046740; GO:0006810; GO:0008270 "DNA binding; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis; spread of virus in host, cell to cell; transport; zinc ion binding" IPR000477; IPR001878; Genome polyprotein [Cleaved into: Movement protein (MP); Capsid protein (CP); Aspartic protease (PR) (EC 3.4.23.-); Reverse transcriptase (RT) (EC 2.7.7.49)] Petunia vein clearing virus (isolate Shepherd) (PVCV) TR38583_c1_g3_i7 Q91DM0 POLG_PVCV1 4.00E-07 GO:0003677; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508; GO:0046740; GO:0006810; GO:0008270 "DNA binding; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis; spread of virus in host, cell to cell; transport; zinc ion binding" IPR000477; IPR001878; Genome polyprotein [Cleaved into: Movement protein (MP); Capsid protein (CP); Aspartic protease (PR) (EC 3.4.23.-); Reverse transcriptase (RT) (EC 2.7.7.49)] Petunia vein clearing virus (isolate Shepherd) (PVCV) TR38585_c0_g1_i4 Q5I2E5 FCN2_BOVIN 3.00E-60 GO:0005581; GO:0001867 "collagen; complement activation, lectin pathway" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) FCN2 Bos taurus (Bovine) TR38585_c0_g1_i5 O00602 FCN1_HUMAN 1.00E-62 GO:0003823; GO:0005509; GO:0030246; GO:0005581; GO:0001867; GO:0005576; GO:0008228 Q2TS39 "antigen binding; calcium ion binding; carbohydrate binding; collagen; complement activation, lectin pathway; extracellular region; opsonization" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) FCN1 FCNM Homo sapiens (Human) TR38585_c0_g1_i6 Q95LU3 FBCD1_MACFA 1.00E-70 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38585_c0_g1_i7 Q95LU3 FBCD1_MACFA 3.00E-73 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38585_c0_g2_i1 E2IYB3 FCNV1_VARKO 3.00E-23 GO:0005576 extracellular region IPR008160; IPR014716; IPR002181; Veficolin-1 (Fragment) Varanus komodoensis (Komodo dragon) TR38586_c1_g2_i1 P86954 ELDP2_PINMA 4.00E-30 GO:0005576 extracellular region IPR000742; IPR013032; EGF-like domain-containing protein 2 Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) TR38586_c2_g2_i2 Q68EY7 C124A_XENLA 1.00E-32 GO:0007049; GO:0051301; GO:0005737; GO:0005815; GO:0030496 cell cycle; cell division; cytoplasm; microtubule organizing center; midbody IPR010422; Coiled-coil domain-containing protein 124-A ccdc124-a Xenopus laevis (African clawed frog) TR38586_c2_g2_i3 Q2TBV6 CC124_BOVIN 2.00E-33 GO:0007049; GO:0051301; GO:0005737; GO:0005815; GO:0030496 cell cycle; cell division; cytoplasm; microtubule organizing center; midbody IPR010422; IPR009071; Coiled-coil domain-containing protein 124 CCDC124 Bos taurus (Bovine) TR38586_c2_g2_i5 Q54GW3 CC124_DICDI 6.00E-18 IPR010422; Coiled-coil domain-containing protein 124 homolog DDB_G0289893 Dictyostelium discoideum (Slime mold) TR38589_c1_g1_i1 P97564 GPAT1_RAT 6.00E-99 GO:0016024; GO:0032869; GO:0004366; GO:0016021; GO:0005741; GO:0005886; GO:0010867; GO:0014823; GO:0046686; GO:0009750; GO:0031667 CDP-diacylglycerol biosynthetic process; cellular response to insulin stimulus; glycerol-3-phosphate O-acyltransferase activity; integral to membrane; mitochondrial outer membrane; plasma membrane; positive regulation of triglyceride biosynthetic process; response to activity; response to cadmium ion; response to fructose stimulus; response to nutrient levels IPR022284; IPR028354; IPR002123; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. "Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15)" Gpam Gpat1 Rattus norvegicus (Rat) TR38589_c1_g1_i3 Q9ES71 GNPAT_RAT 5.00E-37 GO:0021587; GO:0008611; GO:0016287; GO:0006650; GO:0005739; GO:0016290; GO:0030913; GO:0005778; GO:0042493; GO:0070542; GO:0007584; GO:0042594; GO:0007416 cerebellum morphogenesis; ether lipid biosynthetic process; glycerone-phosphate O-acyltransferase activity; glycerophospholipid metabolic process; mitochondrion; palmitoyl-CoA hydrolase activity; paranodal junction assembly; peroxisomal membrane; response to drug; response to fatty acid; response to nutrient; response to starvation; synapse assembly IPR028353; IPR022284; IPR002123; Membrane lipid metabolism; glycerophospholipid metabolism. Dihydroxyacetone phosphate acyltransferase (DAP-AT) (DHAP-AT) (EC 2.3.1.42) (Acyl-CoA:dihydroxyacetonephosphateacyltransferase) (Glycerone-phosphate O-acyltransferase) Gnpat Dhapat Rattus norvegicus (Rat) TR38589_c1_g1_i4 P97564 GPAT1_RAT 9.00E-99 GO:0016024; GO:0032869; GO:0004366; GO:0016021; GO:0005741; GO:0005886; GO:0010867; GO:0014823; GO:0046686; GO:0009750; GO:0031667 CDP-diacylglycerol biosynthetic process; cellular response to insulin stimulus; glycerol-3-phosphate O-acyltransferase activity; integral to membrane; mitochondrial outer membrane; plasma membrane; positive regulation of triglyceride biosynthetic process; response to activity; response to cadmium ion; response to fructose stimulus; response to nutrient levels IPR022284; IPR028354; IPR002123; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. "Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15)" Gpam Gpat1 Rattus norvegicus (Rat) TR38590_c2_g2_i1 Q91VJ5 PQBP1_MOUSE 4.00E-29 GO:0010494; GO:0071598; GO:0005634; GO:0006355; GO:0034063; GO:0006351 "cytoplasmic stress granule; neuronal ribonucleoprotein granule; nucleus; regulation of transcription, DNA-dependent; stress granule assembly; transcription, DNA-dependent" IPR001202; Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) Pqbp1 Npw38 Mus musculus (Mouse) TR38591_c1_g1_i1 Q9ULG1 INO80_HUMAN 1.00E-10 GO:0005524; GO:0016887; GO:0003677; GO:0003678; GO:0031011; GO:0070914; GO:0043014; GO:0051301; GO:0034644; GO:0071479; GO:0006338; GO:0000724; GO:0005874; GO:0000070; GO:0030307; GO:0010571; GO:0045944; GO:2000045; GO:0051225 Q9H9F9; Q16531; P25490 ATP binding; ATPase activity; DNA binding; DNA helicase activity; Ino80 complex; UV-damage excision repair; alpha-tubulin binding; cell division; cellular response to UV; cellular response to ionizing radiation; chromatin remodeling; double-strand break repair via homologous recombination; microtubule; mitotic sister chromatid segregation; positive regulation of cell growth; positive regulation of nuclear cell cycle DNA replication; positive regulation of transcription from RNA polymerase II promoter; regulation of G1/S transition of mitotic cell cycle; spindle assembly IPR020838; IPR014001; IPR001650; IPR027417; IPR000330; DNA helicase INO80 (hINO80) (EC 3.6.4.12) (INO80 complex subunit A) (Putative DNA helicase INO80 complex homolog 1) INO80 INO80A INOC1 KIAA1259 Homo sapiens (Human) TR38591_c1_g2_i1 Q6ZPV2 INO80_MOUSE 0 GO:0005524; GO:0016887; GO:0003677; GO:0003678; GO:0031011; GO:0070914; GO:0051301; GO:0034644; GO:0071479; GO:0006338; GO:0000724; GO:0005874; GO:0000070; GO:0005634; GO:0030307; GO:0010571; GO:0045944; GO:2000045; GO:0051225 ATP binding; ATPase activity; DNA binding; DNA helicase activity; Ino80 complex; UV-damage excision repair; cell division; cellular response to UV; cellular response to ionizing radiation; chromatin remodeling; double-strand break repair via homologous recombination; microtubule; mitotic sister chromatid segregation; nucleus; positive regulation of cell growth; positive regulation of nuclear cell cycle DNA replication; positive regulation of transcription from RNA polymerase II promoter; regulation of G1/S transition of mitotic cell cycle; spindle assembly IPR020838; IPR014001; IPR001650; IPR027417; IPR000330; DNA helicase INO80 (EC 3.6.4.12) (INO80 complex subunit A) (Putative DNA helicase INO80 complex homolog 1) Ino80 Inoc1 Kiaa1259 Mus musculus (Mouse) TR38591_c1_g2_i2 A7TJI3 INO80_VANPO 9.00E-173 GO:0005524; GO:0003677; GO:0006281; GO:0016568; GO:0004386; GO:0005634; GO:0006355; GO:0006351 "ATP binding; DNA binding; DNA repair; chromatin modification; helicase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR020838; IPR014001; IPR001650; IPR027417; IPR000330; Putative DNA helicase INO80 (EC 3.6.4.12) INO80 Kpol_534p5 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus) TR38591_c1_g2_i3 A2BGR3 ERC6L_DANRE 3.00E-34 GO:0005524; GO:0003677; GO:0051301; GO:0000777; GO:0004386; GO:0016539; GO:0007067 ATP binding; DNA binding; cell division; condensed chromosome kinetochore; helicase activity; intein-mediated protein splicing; mitosis IPR014001; IPR001650; IPR006141; IPR027417; IPR000330; IPR011990; IPR019734; DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) ercc6l si:ch211-278b8.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR38591_c1_g2_i4 Q03468 ERCC6_HUMAN 4.00E-38 GO:0005524; GO:0003677; GO:0008094; GO:0007256; GO:0007257; GO:0006284; GO:0003682; GO:0004386; GO:0008630; GO:0035264; GO:0005730; GO:0045494; GO:0032786; GO:0032403; GO:0006290; GO:0009411; GO:0010224; GO:0010165; GO:0010332; GO:0006979; GO:0000303; GO:0009636; GO:0008023; GO:0006366; GO:0006283 Q13216-1 "ATP binding; DNA binding; DNA-dependent ATPase activity; activation of JNKK activity; activation of JUN kinase activity; base-excision repair; chromatin binding; helicase activity; intrinsic apoptotic signaling pathway in response to DNA damage; multicellular organism growth; nucleolus; photoreceptor cell maintenance; positive regulation of DNA-dependent transcription, elongation; protein complex binding; pyrimidine dimer repair; response to UV; response to UV-B; response to X-ray; response to gamma radiation; response to oxidative stress; response to superoxide; response to toxic substance; transcription elongation factor complex; transcription from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair" IPR014001; IPR001650; IPR027417; IPR000330; DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) ERCC6 CSB Homo sapiens (Human) TR38592_c2_g1_i2 Q6CC70 EXO70_YARLI 3.00E-10 GO:0005935; GO:0000145; GO:0006887; GO:0015031 cellular bud neck; exocyst; exocytosis; protein transport IPR016159; IPR004140; Exocyst complex protein EXO70 EXO70 YALI0C11946g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR38592_c2_g4_i1 O54922 EXOC7_RAT 2.00E-130 GO:0005829; GO:0000145; GO:0006887; GO:0005886; GO:0015031 cytosol; exocyst; exocytosis; plasma membrane; protein transport IPR016159; IPR004140; Exocyst complex component 7 (Exocyst complex component Exo70) (rExo70) Exoc7 Exo70 Rattus norvegicus (Rat) TR38592_c2_g4_i2 O35250 EXOC7_MOUSE 6.00E-131 GO:0034451; GO:0005829; GO:0000145; GO:0006887; GO:0032584; GO:0015031 O35382 centriolar satellite; cytosol; exocyst; exocytosis; growth cone membrane; protein transport IPR016159; IPR004140; Exocyst complex component 7 (Exocyst complex component Exo70) Exoc7 Exo70 Mus musculus (Mouse) TR38594_c1_g1_i1 P80303 NUCB2_HUMAN 3.00E-82 GO:0003677; GO:0005794; GO:0005509; GO:0005829; GO:0005783; GO:0005793; GO:0005615; GO:0005640; GO:0005886 P24522 DNA binding; Golgi apparatus; calcium ion binding; cytosol; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; extracellular space; nuclear outer membrane; plasma membrane IPR011992; IPR018247; IPR002048; Nucleobindin-2 (DNA-binding protein NEFA) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] NUCB2 NEFA Homo sapiens (Human) TR38594_c1_g1_i3 Q9JI85 NUCB2_RAT 2.00E-87 GO:0003677; GO:0005797; GO:0005509; GO:0005783; GO:0005576; GO:0016020; GO:0005635 DNA binding; Golgi medial cisterna; calcium ion binding; endoplasmic reticulum; extracellular region; membrane; nuclear envelope IPR011992; IPR018247; IPR002048; Nucleobindin-2 (DNA-binding protein NEFA) (Prepronesfatin) [Cleaved into: Nesfatin-1] Nucb2 Nefa Rattus norvegicus (Rat) TR38595_c0_g1_i2 Q09531 YQP4_CAEEL 3.00E-86 GO:0008060; GO:0043547; GO:0032312; GO:0008270 ARF GTPase activator activity; positive regulation of GTPase activity; regulation of ARF GTPase activity; zinc ion binding IPR001164; Uncharacterized protein F07F6.4 F07F6.4 Caenorhabditis elegans TR38595_c0_g1_i3 Q9D8S3 ARFG3_MOUSE 2.00E-109 GO:0008060; GO:0000139; GO:0005829; GO:0009306; GO:0032312; GO:0016192; GO:0008270 ARF GTPase activator activity; Golgi membrane; cytosol; protein secretion; regulation of ARF GTPase activity; vesicle-mediated transport; zinc ion binding IPR001164; ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) Arfgap3 Mus musculus (Mouse) TR38595_c0_g1_i4 Q9M354 AGD6_ARATH 2.00E-27 GO:0008060; GO:0005829; GO:0005634; GO:0043547; GO:0032312; GO:0008270 ARF GTPase activator activity; cytosol; nucleus; positive regulation of GTPase activity; regulation of ARF GTPase activity; zinc ion binding IPR001164; Probable ADP-ribosylation factor GTPase-activating protein AGD6 (ARF GAP AGD6) (Protein ARF-GAP DOMAIN 6) (AtAGD6) (Protein ZIGA2) AGD6 ZIG2 ZIGA2 At3g53710 F5K20.10 Arabidopsis thaliana (Mouse-ear cress) TR38596_c1_g3_i1 P71359 RECQ_HAEIN 1.00E-49 GO:0005524; GO:0043140; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0009432; GO:0005622 ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA binding; DNA recombination; DNA repair; DNA replication; SOS response; intracellular IPR011545; IPR004589; IPR006293; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR018982; IPR011991; ATP-dependent DNA helicase RecQ (EC 3.6.4.12) recQ HI_0728 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) TR38596_c1_g3_i2 O88700 BLM_MOUSE 9.00E-50 GO:0005524; GO:0043140; GO:0003677; GO:0000729; GO:0006310; GO:0006260; GO:0046632; GO:0072757; GO:0072711; GO:0071479; GO:0005737; GO:0001673; GO:0045950; GO:0070244; GO:0000228; GO:0005654; GO:0046641; GO:0045120; GO:0051098; GO:0005657; GO:0000723 ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA binding; DNA double-strand break processing; DNA recombination; DNA replication; alpha-beta T cell differentiation; cellular response to camptothecin; cellular response to hydroxyurea; cellular response to ionizing radiation; cytoplasm; male germ cell nucleus; negative regulation of mitotic recombination; negative regulation of thymocyte apoptotic process; nuclear chromosome; nucleoplasm; positive regulation of alpha-beta T cell proliferation; pronucleus; regulation of binding; replication fork; telomere maintenance IPR012532; IPR011545; IPR002464; IPR004589; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR018982; IPR011991; Bloom syndrome protein homolog (mBLM) (EC 3.6.4.12) (RecQ helicase homolog) Blm Mus musculus (Mouse) TR38598_c0_g1_i1 Q5RAS0 ACADS_PONAB 9.00E-68 GO:0003995; GO:0004085; GO:0006631; GO:0050660; GO:0005759 acyl-CoA dehydrogenase activity; butyryl-CoA dehydrogenase activity; fatty acid metabolic process; flavin adenine dinucleotide binding; mitochondrial matrix IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Lipid metabolism; mitochondrial fatty acid beta-oxidation. "Short-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD) (EC 1.3.8.1) (Butyryl-CoA dehydrogenase)" ACADS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38598_c0_g1_i2 Q6JQN1 ACD10_HUMAN 1.00E-14 GO:0003995; GO:0050660; GO:0016787; GO:0005739; GO:0016772 "acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; hydrolase activity; mitochondrion; transferase activity, transferring phosphorus-containing groups" IPR006091; IPR009075; IPR013786; IPR009100; IPR002575; IPR023214; IPR006439; IPR011945; IPR011009; IPR023198; Acyl-CoA dehydrogenase family member 10 (ACAD-10) (EC 1.3.99.-) ACAD10 Homo sapiens (Human) TR38598_c0_g1_i3 P51174 ACADL_MOUSE 0 GO:0042413; GO:0019254; GO:0033539; GO:0000062; GO:0050660; GO:0042758; GO:0004466; GO:0005759; GO:0031966; GO:0005739; GO:0045717; GO:0046322; GO:0016401; GO:0051289; GO:0090181; GO:0001659 "carnitine catabolic process; carnitine metabolic process, CoA-linked; fatty acid beta-oxidation using acyl-CoA dehydrogenase; fatty-acyl-CoA binding; flavin adenine dinucleotide binding; long-chain fatty acid catabolic process; long-chain-acyl-CoA dehydrogenase activity; mitochondrial matrix; mitochondrial membrane; mitochondrion; negative regulation of fatty acid biosynthetic process; negative regulation of fatty acid oxidation; palmitoyl-CoA oxidase activity; protein homotetramerization; regulation of cholesterol metabolic process; temperature homeostasis" IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Lipid metabolism; mitochondrial fatty acid beta-oxidation. "Long-chain specific acyl-CoA dehydrogenase, mitochondrial (LCAD) (EC 1.3.8.8)" Acadl Mus musculus (Mouse) TR38599_c0_g1_i1 Q7Z449 CP2U1_HUMAN 8.00E-91 GO:0070330; GO:0008219; GO:0005789; GO:0020037; GO:0016021; GO:0005506; GO:0097267; GO:0006805 aromatase activity; cell death; endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding; omega-hydroxylase P450 pathway; xenobiotic metabolic process IPR001128; IPR017972; IPR002401; IPR008069; Cytochrome P450 2U1 (EC 1.14.14.1) CYP2U1 Homo sapiens (Human) TR38599_c0_g1_i2 Q54D38 C520A_DICDI 6.00E-33 GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705 "heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Probable cytochrome P450 520A1 (EC 1.14.-.-) cyp520A1 DDB_G0292496 Dictyostelium discoideum (Slime mold) TR3860_c0_g1_i1 A5GZY1 NEURM_APLCA 2.00E-16 GO:0005576 extracellular region Neuromacin-like protein Aplysia californica (California sea hare) TR38600_c0_g1_i2 Q9C0C7 AMRA1_HUMAN 1.00E-71 GO:0005776; GO:0006914; GO:0030154; GO:0005737; GO:0031410; GO:0008285; GO:0021915; GO:0043065 P10415; Q14457; P12504 autophagic vacuole; autophagy; cell differentiation; cytoplasm; cytoplasmic vesicle; negative regulation of cell proliferation; neural tube development; positive regulation of apoptotic process IPR015943; IPR001680; IPR019775; IPR017986; Activating molecule in BECN1-regulated autophagy protein 1 AMBRA1 KIAA1736 Homo sapiens (Human) TR38601_c0_g1_i1 Q9H777 RNZ1_HUMAN 4.00E-69 GO:0005829; GO:0016891; GO:0046872; GO:0005634; GO:0042779 "cytosol; endoribonuclease activity, producing 5'-phosphomonoesters; metal ion binding; nucleus; tRNA 3'-trailer cleavage" IPR001279; IPR013471; Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Deleted in Ma29) (ElaC homolog protein 1) (Ribonuclease Z 1) (RNase Z 1) (tRNA 3 endonuclease 1) (tRNase Z 1) ELAC1 D29 Homo sapiens (Human) TR38601_c0_g1_i2 Q9H777 RNZ1_HUMAN 6.00E-78 GO:0005829; GO:0016891; GO:0046872; GO:0005634; GO:0042779 "cytosol; endoribonuclease activity, producing 5'-phosphomonoesters; metal ion binding; nucleus; tRNA 3'-trailer cleavage" IPR001279; IPR013471; Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Deleted in Ma29) (ElaC homolog protein 1) (Ribonuclease Z 1) (RNase Z 1) (tRNA 3 endonuclease 1) (tRNase Z 1) ELAC1 D29 Homo sapiens (Human) TR38601_c0_g1_i3 Q834G2 RNZ_ENTFA 7.00E-30 GO:0042781; GO:0042779; GO:0008270 3'-tRNA processing endoribonuclease activity; tRNA 3'-trailer cleavage; zinc ion binding IPR001279; IPR013471; Ribonuclease Z (RNase Z) (EC 3.1.26.11) (tRNA 3 endonuclease) (tRNase Z) rnz EF_1691 Enterococcus faecalis (strain ATCC 700802 / V583) TR38601_c0_g1_i4 A3PEI3 RNZ_PROM0 3.00E-33 GO:0042781; GO:0042779; GO:0008270 3'-tRNA processing endoribonuclease activity; tRNA 3'-trailer cleavage; zinc ion binding IPR001279; IPR013471; Ribonuclease Z (RNase Z) (EC 3.1.26.11) (tRNA 3 endonuclease) (tRNase Z) rnz P9301_15351 Prochlorococcus marinus (strain MIT 9301) TR38603_c1_g1_i2 Q8TDX7 NEK7_HUMAN 2.00E-08 GO:0005524; GO:0000910; GO:0005737; GO:0046872; GO:0005874; GO:0005815; GO:0005634; GO:0004674; GO:0007346; GO:0051225; GO:0000922 ATP binding; cytokinesis; cytoplasm; metal ion binding; microtubule; microtubule organizing center; nucleus; protein serine/threonine kinase activity; regulation of mitotic cell cycle; spindle assembly; spindle pole IPR011009; IPR000719; IPR017441; IPR001245; IPR002290; IPR008271; Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) NEK7 Homo sapiens (Human) TR38603_c1_g1_i3 Q55BN8 NEK2_DICDI 5.00E-07 GO:0005524; GO:0005813; GO:0007098; GO:0045335; GO:0004674 ATP binding; centrosome; centrosome cycle; phagocytic vesicle; protein serine/threonine kinase activity IPR011009; IPR000719; IPR002290; IPR008271; Probable serine/threonine-protein kinase nek2 (EC 2.7.11.1) (Never in mitosis protein A-related protein kinase 2) (NimA-related protein kinase 2) nek2 DDB_G0270814 Dictyostelium discoideum (Slime mold) TR38604_c0_g1_i2 Q9UBQ7 GRHPR_HUMAN 3.00E-98 GO:0051287; GO:0070402; GO:0034641; GO:0007588; GO:0008465; GO:0046487; GO:0030267; GO:0016618; GO:0005782; GO:0042803; GO:0051259 NAD binding; NADPH binding; cellular nitrogen compound metabolic process; excretion; glycerate dehydrogenase activity; glyoxylate metabolic process; glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; peroxisomal matrix; protein homodimerization activity; protein oligomerization IPR006139; IPR006140; IPR016040; Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81) GRHPR GLXR MSTP035 Homo sapiens (Human) TR38604_c0_g1_i3 Q57IH8 GHRB_SALCH 7.00E-42 GO:0051287; GO:0005737; GO:0030267; GO:0016618; GO:0005886 NAD binding; cytoplasm; glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; plasma membrane IPR006139; IPR006140; IPR023756; IPR016040; Glyoxylate/hydroxypyruvate reductase B (EC 1.1.1.79) (EC 1.1.1.81) ghrB SCH_3578 Salmonella choleraesuis (strain SC-B67) TR38604_c0_g1_i5 Q9UBQ7 GRHPR_HUMAN 3.00E-99 GO:0051287; GO:0070402; GO:0034641; GO:0007588; GO:0008465; GO:0046487; GO:0030267; GO:0016618; GO:0005782; GO:0042803; GO:0051259 NAD binding; NADPH binding; cellular nitrogen compound metabolic process; excretion; glycerate dehydrogenase activity; glyoxylate metabolic process; glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; peroxisomal matrix; protein homodimerization activity; protein oligomerization IPR006139; IPR006140; IPR016040; Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81) GRHPR GLXR MSTP035 Homo sapiens (Human) TR38604_c0_g1_i6 A1RYE4 GYAR_THEPD 2.00E-72 GO:0051287; GO:0005737; GO:0047964 NAD binding; cytoplasm; glyoxylate reductase activity IPR006139; IPR006140; IPR023519; IPR016040; Glyoxylate reductase (EC 1.1.1.26) gyaR Tpen_0823 Thermofilum pendens (strain Hrk 5) TR38606_c0_g2_i1 Q504A5 TPMT_DANRE 6.00E-42 GO:0005737; GO:0008119 cytoplasm; thiopurine S-methyltransferase activity IPR025835; IPR008854; Probable thiopurine S-methyltransferase (Thiopurine methyltransferase) (EC 2.1.1.67) tpmt zgc:109981 Danio rerio (Zebrafish) (Brachydanio rerio) TR38606_c1_g1_i1 B1JIK2 MTNK_YERPY 1.00E-13 GO:0005524; GO:0019284; GO:0019509; GO:0046522 ATP binding; L-methionine biosynthetic process from S-adenosylmethionine; L-methionine salvage from methylthioadenosine; S-methyl-5-thioribose kinase activity IPR002575; IPR011009; IPR009212; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 2/2. Methylthioribose kinase (MTR kinase) (EC 2.7.1.100) mtnK YPK_3317 Yersinia pseudotuberculosis serotype O:3 (strain YPIII) TR38606_c1_g1_i2 A1JP08 MTNK_YERE8 6.00E-13 GO:0005524; GO:0019284; GO:0019509; GO:0046522 ATP binding; L-methionine biosynthetic process from S-adenosylmethionine; L-methionine salvage from methylthioadenosine; S-methyl-5-thioribose kinase activity IPR002575; IPR011009; IPR009212; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 2/2. Methylthioribose kinase (MTR kinase) (EC 2.7.1.100) mtnK YE3228 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) TR38606_c1_g2_i1 Q63HQ0 AP1AR_HUMAN 4.00E-08 GO:0005794; GO:0034613; GO:0005769; GO:0005770; GO:2000146; GO:1900025; GO:0005730; GO:0015031; GO:0034315; GO:0030133 Golgi apparatus; cellular protein localization; early endosome; late endosome; negative regulation of cell motility; negative regulation of substrate adhesion-dependent cell spreading; nucleolus; protein transport; regulation of Arp2/3 complex-mediated actin nucleation; transport vesicle AP-1 complex-associated regulatory protein (2c18) (Adapter-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) AP1AR C4orf16 PRO0971 Homo sapiens (Human) TR38606_c1_g4_i1 A8FCG6 MTNK_BACP2 8.00E-24 GO:0005524; GO:0019284; GO:0019509; GO:0046522 ATP binding; L-methionine biosynthetic process from S-adenosylmethionine; L-methionine salvage from methylthioadenosine; S-methyl-5-thioribose kinase activity IPR002575; IPR011009; IPR009212; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 2/2. Methylthioribose kinase (MTR kinase) (EC 2.7.1.100) mtnK BPUM_1250 Bacillus pumilus (strain SAFR-032) TR38607_c0_g1_i1 Q7T6Y2 YR831_MIMIV 7.00E-41 GO:0005524; GO:0009190; GO:0016021; GO:0035556; GO:0016849; GO:0004674 ATP binding; cyclic nucleotide biosynthetic process; integral to membrane; intracellular signal transduction; phosphorus-oxygen lyase activity; protein serine/threonine kinase activity IPR001054; IPR011009; IPR024370; IPR000719; IPR017441; IPR001245; IPR002290; IPR008271; Putative serine/threonine-protein kinase/receptor R831 (EC 2.7.11.1) MIMI_R831 Acanthamoeba polyphaga mimivirus (APMV) TR38608_c2_g1_i1 P91851 YUG4_CAEEL 6.00E-36 GO:0009435; GO:0016779 NAD biosynthetic process; nucleotidyltransferase activity IPR004821; IPR005248; IPR014729; Uncharacterized protein F26H9.4 F26H9.4 Caenorhabditis elegans TR38608_c2_g1_i2 Q99JR6 NMNA3_MOUSE 2.00E-73 GO:0005524; GO:0009435; GO:0005739; GO:0000309; GO:0004515; GO:0009611 ATP binding; NAD biosynthetic process; mitochondrion; nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; response to wounding IPR004821; IPR005248; IPR014729; Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1. Nicotinamide mononucleotide adenylyltransferase 3 (NMN adenylyltransferase 3) (EC 2.7.7.1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1) (EC 2.7.7.18) Nmnat3 Mus musculus (Mouse) TR38608_c2_g1_i3 Q0VD50 NMNA1_BOVIN 4.00E-91 GO:0005524; GO:0009435; GO:0000309; GO:0004515; GO:0005634 ATP binding; NAD biosynthetic process; nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; nucleus IPR004821; IPR005248; IPR014729; Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1. Nicotinamide mononucleotide adenylyltransferase 1 (NMN adenylyltransferase 1) (EC 2.7.7.1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1) (EC 2.7.7.18) NMNAT1 Bos taurus (Bovine) TR38608_c2_g1_i4 Q96T66 NMNA3_HUMAN 4.00E-74 GO:0005524; GO:0009435; GO:0005829; GO:0005739; GO:0000309; GO:0004515; GO:0009611; GO:0006767 ATP binding; NAD biosynthetic process; cytosol; mitochondrion; nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; response to wounding; water-soluble vitamin metabolic process IPR004821; IPR005248; IPR014729; Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1. Nicotinamide mononucleotide adenylyltransferase 3 (NMN adenylyltransferase 3) (Nicotinate-nucleotide adenylyltransferase 3) (NaMN adenylyltransferase 3) (EC 2.7.7.18) (Pyridine nucleotide adenylyltransferase 3) (PNAT-3) (EC 2.7.7.1) NMNAT3 FKSG76 Homo sapiens (Human) TR38610_c3_g2_i1 Q8MXQ2 RB32C_DICDI 3.00E-40 GO:0005525; GO:0015031; GO:0007264 GTP binding; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-32C rab32C DDB_G0275675 Dictyostelium discoideum (Slime mold) TR38610_c3_g2_i4 P17608 RYH1_SCHPO 7.00E-22 GO:0005525; GO:0003924; GO:0000139; GO:0071470; GO:0005829; GO:0010008; GO:0006886; GO:0005634; GO:0005886; GO:0042147; GO:0007264 "GTP binding; GTPase activity; Golgi membrane; cellular response to osmotic stress; cytosol; endosome membrane; intracellular protein transport; nucleus; plasma membrane; retrograde transport, endosome to Golgi; small GTPase mediated signal transduction" IPR027417; IPR005225; IPR001806; IPR003579; GTP-binding protein ryh1 ryh1 hos1 its6 SPAC4C5.02c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38610_c3_g2_i6 Q13637 RAB32_HUMAN 5.00E-103 GO:0005525; GO:0005739; GO:0045335; GO:0030670; GO:0090382; GO:0015031; GO:0007264 GTP binding; mitochondrion; phagocytic vesicle; phagocytic vesicle membrane; phagosome maturation; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-32 RAB32 Homo sapiens (Human) TR38610_c3_g2_i7 Q9SF91 RAE1E_ARATH 2.00E-25 GO:0005525; GO:0000139; GO:0005886; GO:0015031; GO:0007264 GTP binding; Golgi membrane; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein RABE1e (AtRABE1e) (Ras-related protein Rab8E) (AtRab8E) RABE1E RAB8E At3g09900 F8A24.5 Arabidopsis thaliana (Mouse-ear cress) TR38610_c3_g2_i8 Q13637 RAB32_HUMAN 2.00E-103 GO:0005525; GO:0005739; GO:0045335; GO:0030670; GO:0090382; GO:0015031; GO:0007264 GTP binding; mitochondrion; phagocytic vesicle; phagocytic vesicle membrane; phagosome maturation; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-32 RAB32 Homo sapiens (Human) TR38611_c10_g1_i1 Q9LXA8 BXL6_ARATH 7.00E-100 GO:0005975; GO:0005578; GO:0005774; GO:0009044 "carbohydrate metabolic process; proteinaceous extracellular matrix; vacuolar membrane; xylan 1,4-beta-xylosidase activity" IPR026891; IPR026892; IPR002772; IPR001764; IPR017853; Probable beta-D-xylosidase 6 (AtBXL6) (EC 3.2.1.-) BXL6 At5g10560 F12B17.90 Arabidopsis thaliana (Mouse-ear cress) TR38611_c10_g3_i4 P78314 3BP2_HUMAN 4.00E-08 GO:0005070; GO:0005543; GO:0007165 Q9UJU6; Q96B97; Q9H2K2; P15498; P52735 SH3/SH2 adaptor activity; phospholipid binding; signal transduction IPR011993; IPR001849; IPR000980; SH3 domain-binding protein 2 (3BP-2) SH3BP2 3BP2 RES4-23 Homo sapiens (Human) TR38611_c10_g3_i6 P78314 3BP2_HUMAN 3.00E-08 GO:0005070; GO:0005543; GO:0007165 Q9UJU6; Q96B97; Q9H2K2; P15498; P52735 SH3/SH2 adaptor activity; phospholipid binding; signal transduction IPR011993; IPR001849; IPR000980; SH3 domain-binding protein 2 (3BP-2) SH3BP2 3BP2 RES4-23 Homo sapiens (Human) TR38611_c10_g4_i1 Q9SGZ5 BXL7_ARATH 5.00E-75 GO:0048046; GO:0005975; GO:0009507; GO:0004553; GO:0009505; GO:0009506; GO:0005578 "apoplast; carbohydrate metabolic process; chloroplast; hydrolase activity, hydrolyzing O-glycosyl compounds; plant-type cell wall; plasmodesma; proteinaceous extracellular matrix" IPR026891; IPR026892; IPR002772; IPR001764; IPR017853; Probable beta-D-xylosidase 7 (AtBXL7) (EC 3.2.1.-) BXL7 At1g78060 F28K19.27 F28K19.32 Arabidopsis thaliana (Mouse-ear cress) TR38613_c0_g1_i1 Q6NS46 RRP5_MOUSE 9.00E-72 GO:0003723; GO:0006915; GO:0005829; GO:0006397; GO:0005730; GO:0043123; GO:0006364; GO:0006355 "RNA binding; apoptotic process; cytosol; mRNA processing; nucleolus; positive regulation of I-kappaB kinase/NF-kappaB cascade; rRNA processing; regulation of transcription, DNA-dependent" IPR003107; IPR012340; IPR003029; IPR022967; IPR008847; IPR013026; IPR011990; Protein RRP5 homolog (Apoptosis-linked gene 4 protein) (Programmed cell death protein 11) Pdcd11 Alg4 Kiaa0185 Mus musculus (Mouse) TR38613_c0_g1_i4 Q14690 RRP5_HUMAN 7.00E-53 GO:0003723; GO:0005829; GO:0006397; GO:0005730; GO:0005634; GO:0006364 P19838 RNA binding; cytosol; mRNA processing; nucleolus; nucleus; rRNA processing IPR003107; IPR012340; IPR003029; IPR022967; IPR008847; IPR013026; IPR011990; Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) PDCD11 KIAA0185 Homo sapiens (Human) TR38615_c2_g2_i1 Q5RE52 APC5_PONAB 4.00E-144 GO:0005680; GO:0051301; GO:0007067; GO:0070979 anaphase-promoting complex; cell division; mitosis; protein K11-linked ubiquitination IPR026000; IPR011990; Protein modification; protein ubiquitination. Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5) ANAPC5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38615_c3_g1_i2 Q60HE6 MRE11_MACFA 0 GO:0006302; GO:0004519; GO:0004527; GO:0030145; GO:0007126; GO:0090305; GO:0005634 double-strand break repair; endonuclease activity; exonuclease activity; manganese ion binding; meiosis; nucleic acid phosphodiester bond hydrolysis; nucleus IPR003701; IPR007281; IPR004843; Double-strand break repair protein MRE11A (Meiotic recombination 11 homolog A) (MRE11 homolog A) MRE11A QtrA-18006 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38616_c4_g1_i1 Q8HY01 CD209_NOMCO 2.00E-13 GO:0007155; GO:0006897; GO:0045087; GO:0016021; GO:0005537; GO:0046872 cell adhesion; endocytosis; innate immune response; integral to membrane; mannose binding; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; CD209 antigen (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN1) (CD antigen CD209) CD209 Nomascus concolor (Black crested gibbon) (Hylobates concolor) TR38616_c4_g1_i10 Q9YGN4 FICB_GLOBR 2.00E-12 GO:0030246; GO:0005576; GO:0046872 carbohydrate binding; extracellular region; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; Snaclec salmorin subunit B Gloydius brevicaudus (Korean slamosa snake) (Agkistrodon halys brevicaudus) TR38616_c4_g1_i4 P49259 PLA2R_BOVIN 4.00E-22 GO:0030246; GO:0009986; GO:0001816; GO:0005576; GO:0016021; GO:1900139; GO:1900138; GO:0090403; GO:0043274; GO:0005886; GO:0043517; GO:0090238; GO:0072593; GO:0004872; GO:0006898; GO:0090399 "carbohydrate binding; cell surface; cytokine production; extracellular region; integral to membrane; negative regulation of arachidonic acid secretion; negative regulation of phospholipase A2 activity; oxidative stress-induced premature senescence; phospholipase binding; plasma membrane; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of arachidonic acid secretion; reactive oxygen species metabolic process; receptor activity; receptor-mediated endocytosis; replicative senescence" IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR000772; Secretory phospholipase A2 receptor (PLA2-R) (PLA2R) (180 kDa secretory phospholipase A2 receptor) (M-type receptor) [Cleaved into: Soluble secretory phospholipase A2 receptor (Soluble PLA2-R) (Soluble PLA2R)] PLA2R1 Bos taurus (Bovine) TR38616_c4_g1_i5 P22897 MRC1_HUMAN 1.00E-30 GO:0010008; GO:0005887; GO:0005537; GO:0004872; GO:0006898 endosome membrane; integral to plasma membrane; mannose binding; receptor activity; receptor-mediated endocytosis IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206) MRC1 CLEC13D CLEC13DL MRC1L1 Homo sapiens (Human) TR38616_c4_g1_i6 A6QP79 COL12_BOVIN 4.00E-09 GO:0030246; GO:0005581; GO:0006955; GO:0016021; GO:0030169; GO:0046872; GO:0006910; GO:0008329 "carbohydrate binding; collagen; immune response; integral to membrane; low-density lipoprotein particle binding; metal ion binding; phagocytosis, recognition; signaling pattern recognition receptor activity" IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-12 (Collectin placenta protein 1) (CL-P1) COLEC12 CLP1 Bos taurus (Bovine) TR38616_c4_g1_i7 Q64449 MRC2_MOUSE 5.00E-32 GO:0030246; GO:0009986; GO:0005518; GO:0006897; GO:0016021; GO:0005886 carbohydrate binding; cell surface; collagen binding; endocytosis; integral to membrane; plasma membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; C-type mannose receptor 2 (Lectin lambda) (Macrophage mannose receptor 2) (CD antigen CD280) Mrc2 Kiaa0709 Mus musculus (Mouse) TR38616_c4_g1_i8 Q09GK0 CLECB_PHIOL 4.00E-15 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Snaclec subunit B (C-type lectin subunit B) Philodryas olfersii (Green snake) TR38616_c4_g1_i9 A7X3Z0 LEC_THRJA 1.00E-18 GO:0030246; GO:0005576; GO:0046872 carbohydrate binding; extracellular region; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; C-type lectin lectoxin-Thr1 (CTL) Thrasops jacksonii (Jackson's black tree snake) TR38617_c2_g1_i2 Q9H3K2 GHITM_HUMAN 1.00E-102 GO:0006915; GO:0016021; GO:0005743 Q6PDS3 apoptotic process; integral to membrane; mitochondrial inner membrane IPR010539; IPR006214; Growth hormone-inducible transmembrane protein (Dermal papilla-derived protein 2) (Mitochondrial morphology and cristae structure 1) (MICS1) (Transmembrane BAX inhibitor motif-containing protein 5) GHITM DERP2 MICS1 TMBIM5 My021 UNQ244/PRO281 Homo sapiens (Human) TR38617_c2_g1_i4 P55062 BI1_RAT 4.00E-08 GO:0006915; GO:0005789; GO:0016021; GO:0030324; GO:0043066; GO:0006986; GO:0007283 apoptotic process; endoplasmic reticulum membrane; integral to membrane; lung development; negative regulation of apoptotic process; response to unfolded protein; spermatogenesis IPR006213; IPR006214; Bax inhibitor 1 (BI-1) (Testis-enhanced gene transcript protein) (Transmembrane BAX inhibitor motif-containing protein 6) Tmbim6 Bi1 Tegt Rattus norvegicus (Rat) TR38618_c1_g2_i3 Q9Z2W0 DNPEP_MOUSE 0 GO:0004177; GO:0005737; GO:0008237; GO:0006508; GO:0008270 aminopeptidase activity; cytoplasm; metallopeptidase activity; proteolysis; zinc ion binding IPR001948; IPR023358; Aspartyl aminopeptidase (EC 3.4.11.21) Dnpep Mus musculus (Mouse) TR38618_c1_g2_i4 Q19087 DNPEP_CAEEL 1.00E-164 GO:0004177; GO:0005737; GO:0008237; GO:0006508; GO:0008270 Itself aminopeptidase activity; cytoplasm; metallopeptidase activity; proteolysis; zinc ion binding IPR001948; IPR023358; Putative aspartyl aminopeptidase (EC 3.4.11.21) F01F1.9 Caenorhabditis elegans TR38619_c0_g3_i1 Q498E7 SMAL1_XENLA 0 GO:0005524; GO:0003677; GO:0008094; GO:0036310; GO:0016568; GO:0004386; GO:0005634; GO:0006357 ATP binding; DNA binding; DNA-dependent ATPase activity; annealing helicase activity; chromatin modification; helicase activity; nucleus; regulation of transcription from RNA polymerase II promoter IPR010003; IPR014001; IPR001650; IPR027417; IPR000330; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (Sucrose nonfermenting protein 2-like 1) smarcal1 harp Xenopus laevis (African clawed frog) TR38621_c0_g1_i1 P0CS14 DDI1_CRYNJ 6.00E-75 GO:0004190; GO:0005737; GO:0015031; GO:0006508 aspartic-type endopeptidase activity; cytoplasm; protein transport; proteolysis IPR019103; IPR021109; IPR009060; IPR015940; IPR000449; IPR000626; DNA damage-inducible protein 1 DDI1 CNC00460 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR38621_c0_g1_i2 Q6TH22 DDI2_DANRE 4.00E-142 GO:0004190; GO:0006508 aspartic-type endopeptidase activity; proteolysis IPR019103; IPR021109; IPR000626; Protein DDI1 homolog 2 ddi2 Danio rerio (Zebrafish) (Brachydanio rerio) TR38621_c0_g1_i3 Q6TH22 DDI2_DANRE 3.00E-141 GO:0004190; GO:0006508 aspartic-type endopeptidase activity; proteolysis IPR019103; IPR021109; IPR000626; Protein DDI1 homolog 2 ddi2 Danio rerio (Zebrafish) (Brachydanio rerio) TR38624_c0_g1_i1 A0M8U1 ST7_CHICK 0 GO:0016021 integral to membrane IPR007311; Suppressor of tumorigenicity 7 protein homolog ST7 Gallus gallus (Chicken) TR38624_c0_g1_i5 A0M8U1 ST7_CHICK 0 GO:0016021 integral to membrane IPR007311; Suppressor of tumorigenicity 7 protein homolog ST7 Gallus gallus (Chicken) TR38625_c0_g1_i4 Q96KG7 MEG10_HUMAN 4.00E-45 GO:0016323; GO:0042995; GO:0034109; GO:0016021; GO:0055001; GO:0001891; GO:0043654; GO:0051147; GO:0048641; GO:0014719; GO:0014816; GO:0014841 basolateral plasma membrane; cell projection; homotypic cell-cell adhesion; integral to membrane; muscle cell development; phagocytic cup; recognition of apoptotic cell; regulation of muscle cell differentiation; regulation of skeletal muscle tissue development; satellite cell activation; satellite cell differentiation; satellite cell proliferation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) TR38625_c0_g1_i5 Q2PZL6 FAT4_MOUSE 2.00E-07 GO:0045177; GO:0001658; GO:0005509; GO:0048565; GO:0001736; GO:0003007; GO:0007156; GO:0060122; GO:0016021; GO:0001822; GO:0043931; GO:0005886; GO:0007009 apical part of cell; branching involved in ureteric bud morphogenesis; calcium ion binding; digestive tract development; establishment of planar polarity; heart morphogenesis; homophilic cell adhesion; inner ear receptor stereocilium organization; integral to membrane; kidney development; ossification involved in bone maturation; plasma membrane; plasma membrane organization IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) Fat4 Fatj Mus musculus (Mouse) TR38625_c0_g1_i6 O88281 MEGF6_RAT 1.00E-43 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR002049; IPR011489; IPR009030; Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) TR38625_c0_g1_i7 Q80V70 MEGF6_MOUSE 4.00E-45 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR013111; IPR002049; IPR011489; IPR009030; Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) TR38625_c0_g3_i2 P68827 NAGPA_BOVIN 1.00E-10 GO:0032580; GO:0003944; GO:0016021; GO:0006486 Golgi cisterna membrane; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity; integral to membrane; protein glycosylation IPR018711; IPR000742; IPR013032; Protein modification; protein glycosylation. N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) (Mannose 6-phosphate-uncovering enzyme) (Phosphodiester alpha-GlcNAcase) NAGPA Bos taurus (Bovine) TR38627_c0_g1_i3 Q6PHF0 CHM1A_DANRE 1.00E-67 GO:0021549; GO:0010008; GO:0015031 cerebellum development; endosome membrane; protein transport IPR005024; Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) chmp1a km0004 pcoln3 zgc:65914 zgc:85863 Danio rerio (Zebrafish) (Brachydanio rerio) TR38628_c1_g2_i3 P0C7N9 PSMG4_MOUSE 1.00E-21 Proteasome assembly chaperone 4 (PAC-4) (mPAC4) Psmg4 Pac4 Mus musculus (Mouse) TR38631_c0_g2_i1 Q24157 BRN_DROME 3.00E-37 GO:0000139; GO:0005795; GO:0007219; GO:0046981; GO:0007298; GO:0005576; GO:0047915; GO:0007293; GO:0006688; GO:0008314; GO:0016021; GO:0042248; GO:0001744; GO:0007299; GO:0006486 "Golgi membrane; Golgi stack; Notch signaling pathway; beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity; border follicle cell migration; extracellular region; ganglioside galactosyltransferase activity; germarium-derived egg chamber formation; glycosphingolipid biosynthetic process; gurken receptor signaling pathway; integral to membrane; maintenance of polarity of follicular epithelium; optic lobe placode formation; ovarian follicle cell-cell adhesion; protein glycosylation" IPR002659; "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) TR38631_c0_g2_i2 Q5TJE8 B3GT4_CANFA 6.00E-18 GO:0000139; GO:0047915; GO:0016021; GO:0006486 Golgi membrane; ganglioside galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 4 (Beta-1,3-GalTase 4) (Beta3Gal-T4) (Beta3GalT4) (GalT4) (b3Gal-T4) (EC 2.4.1.62) (Gal-T2) (Ganglioside galactosyltransferase) (UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase)" B3GALT4 Canis familiaris (Dog) (Canis lupus familiaris) TR38631_c0_g2_i4 Q24157 BRN_DROME 2.00E-39 GO:0000139; GO:0005795; GO:0007219; GO:0046981; GO:0007298; GO:0005576; GO:0047915; GO:0007293; GO:0006688; GO:0008314; GO:0016021; GO:0042248; GO:0001744; GO:0007299; GO:0006486 "Golgi membrane; Golgi stack; Notch signaling pathway; beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity; border follicle cell migration; extracellular region; ganglioside galactosyltransferase activity; germarium-derived egg chamber formation; glycosphingolipid biosynthetic process; gurken receptor signaling pathway; integral to membrane; maintenance of polarity of follicular epithelium; optic lobe placode formation; ovarian follicle cell-cell adhesion; protein glycosylation" IPR002659; "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) TR38634_c2_g2_i1 P62168 NCS1_RAT 1.00E-49 GO:0032580; GO:0030424; GO:0005509; GO:0008427; GO:0030054; GO:0031410; GO:0005829; GO:0030425; GO:0000287; GO:0048471; GO:0048015; GO:0005886; GO:0045921; GO:0014069; GO:0045211; GO:0010975; GO:0005245 P84080; P14100 Golgi cisterna membrane; axon; calcium ion binding; calcium-dependent protein kinase inhibitor activity; cell junction; cytoplasmic vesicle; cytosol; dendrite; magnesium ion binding; perinuclear region of cytoplasm; phosphatidylinositol-mediated signaling; plasma membrane; positive regulation of exocytosis; postsynaptic density; postsynaptic membrane; regulation of neuron projection development; voltage-gated calcium channel activity IPR011992; IPR018247; IPR002048; IPR001125; Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein) Ncs1 Flup Freq Rattus norvegicus (Rat) TR38634_c2_g2_i2 Q2KI69 KCIP4_BOVIN 7.00E-81 GO:0005509; GO:0005886; GO:0005267; GO:0005244 calcium ion binding; plasma membrane; potassium channel activity; voltage-gated ion channel activity IPR011992; IPR018247; IPR002048; IPR001125; Kv channel-interacting protein 4 (KChIP4) KCNIP4 Bos taurus (Bovine) TR38634_c2_g2_i3 Q06389 NCS1_YEAST 1.00E-41 GO:0000139; GO:0005509; GO:0033101; GO:0008047; GO:0009966 P53112; P39104 Golgi membrane; calcium ion binding; cellular bud membrane; enzyme activator activity; regulation of signal transduction IPR011992; IPR018247; IPR002048; IPR001125; Calcium-binding protein NCS-1 FRQ1 NCS1 YDR373W D9481.6 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR38634_c2_g2_i4 Q2KI69 KCIP4_BOVIN 2.00E-80 GO:0005509; GO:0005886; GO:0005267; GO:0005244 calcium ion binding; plasma membrane; potassium channel activity; voltage-gated ion channel activity IPR011992; IPR018247; IPR002048; IPR001125; Kv channel-interacting protein 4 (KChIP4) KCNIP4 Bos taurus (Bovine) TR38637_c0_g1_i1 Q54ZP5 WDR48_DICDI 6.00E-35 IPR021772; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 48 homolog DDB_G0277533 Dictyostelium discoideum (Slime mold) TR38637_c0_g3_i1 Q05B17 WDR48_XENTR 3.00E-157 GO:0005764; GO:0005634; GO:0016579 lysosome; nucleus; protein deubiquitination IPR021772; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 48 (USP1-associated factor 1) wdr48 uaf1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38637_c0_g5_i1 Q4R2Z6 WDR48_MACFA 4.00E-61 GO:0005764; GO:0005634; GO:0016579 lysosome; nucleus; protein deubiquitination IPR021772; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 48 (USP1-associated factor 1) WDR48 UAF1 QtsA-20837 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38638_c0_g1_i2 Q9WVA1 TIM8A_RAT 3.00E-24 GO:0005743; GO:0006626; GO:0008270 mitochondrial inner membrane; protein targeting to mitochondrion; zinc ion binding IPR004217; Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1 homolog) Timm8a Ddp1 Tim8a Rattus norvegicus (Rat) TR38639_c0_g1_i3 Q9D9W0 CU056_MOUSE 1.00E-13 IPR026715; Speriolin-like protein (Spermatogenesis and centriole-associated protein 1-like protein) Spatc1l Mus musculus (Mouse) TR38641_c1_g1_i1 P36014 GPX1_YEAST 7.00E-17 GO:0034599; GO:0031315; GO:0004602; GO:0005782; GO:0007031; GO:0047066 P36156; P38799 cellular response to oxidative stress; extrinsic to mitochondrial outer membrane; glutathione peroxidase activity; peroxisomal matrix; peroxisome organization; phospholipid-hydroperoxide glutathione peroxidase activity IPR000889; IPR012336; Glutathione peroxidase 1 (EC 1.11.1.9) GPX1 YKL026C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR38641_c1_g1_i3 Q4AEH5 GPX3_HYLLA 3.00E-47 GO:0005615; GO:0004602; GO:0051289; GO:0006979; GO:0008430 extracellular space; glutathione peroxidase activity; protein homotetramerization; response to oxidative stress; selenium binding IPR000889; IPR012336; Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC 1.11.1.9) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P) GPX3 Hylobates lar (Common gibbon) (White-handed gibbon) TR38641_c1_g1_i4 Q4AEH5 GPX3_HYLLA 4.00E-44 GO:0005615; GO:0004602; GO:0051289; GO:0006979; GO:0008430 extracellular space; glutathione peroxidase activity; protein homotetramerization; response to oxidative stress; selenium binding IPR000889; IPR012336; Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC 1.11.1.9) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P) GPX3 Hylobates lar (Common gibbon) (White-handed gibbon) TR38643_c2_g1_i1 A6QR44 DGCR8_BOVIN 3.00E-83 GO:0005737; GO:0003725; GO:0046872; GO:0015630; GO:0005730; GO:0031053 cytoplasm; double-stranded RNA binding; metal ion binding; microtubule cytoskeleton; nucleolus; primary miRNA processing IPR014720; IPR001202; Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8 homolog) DGCR8 Bos taurus (Bovine) TR38644_c3_g1_i1 P49754 VPS41_HUMAN 0 GO:0048193; GO:0005798; GO:0030897; GO:0005829; GO:0005769; GO:0006886; GO:0005770; GO:0005765; GO:0016020; GO:0005874; GO:0016192; GO:0008270 Q9H9C1 Golgi vesicle transport; Golgi-associated vesicle; HOPS complex; cytosol; early endosome; intracellular protein transport; late endosome; lysosomal membrane; membrane; microtubule; vesicle-mediated transport; zinc ion binding IPR000547; IPR011990; IPR016902; IPR015943; IPR017986; IPR001841; IPR013083; Vacuolar protein sorting-associated protein 41 homolog (S53) VPS41 Homo sapiens (Human) TR38646_c1_g1_i1 Q5VT25 MRCKA_HUMAN 0 GO:0005524; GO:0031532; GO:0042641; GO:0031032; GO:0031252; GO:0016477; GO:0005911; GO:0005737; GO:0035556; GO:0000287; GO:0000226; GO:0007097; GO:0005543; GO:0004674; GO:0005083 Itself; P60953 ATP binding; actin cytoskeleton reorganization; actomyosin; actomyosin structure organization; cell leading edge; cell migration; cell-cell junction; cytoplasm; intracellular signal transduction; magnesium ion binding; microtubule cytoskeleton organization; nuclear migration; phospholipid binding; protein serine/threonine kinase activity; small GTPase regulator activity IPR000961; IPR001180; IPR000095; IPR011009; IPR014930; IPR017892; IPR001849; IPR002219; IPR000719; IPR017441; IPR002290; IPR008271; IPR026611; Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) CDC42BPA KIAA0451 Homo sapiens (Human) TR38646_c2_g1_i1 Q9Y7U6 RGF1_SCHPO 5.00E-12 GO:0005089; GO:0051666; GO:0000935; GO:0000917; GO:0051285; GO:0009272; GO:0035556; GO:0005634; GO:0005543; GO:0035025; GO:0051518; GO:0032319; GO:0008360; GO:0090334 Rho guanyl-nucleotide exchange factor activity; actin cortical patch localization; barrier septum; barrier septum assembly; cell cortex of cell tip; fungal-type cell wall biogenesis; intracellular signal transduction; nucleus; phospholipid binding; positive regulation of Rho protein signal transduction; positive regulation of bipolar cell growth; regulation of Rho GTPase activity; regulation of cell shape; regulation of cell wall (1->3)-beta-D-glucan biosynthetic process IPR001180; IPR000591; IPR000219; IPR011993; IPR001849; IPR011991; Rho1 guanine nucleotide exchange factor 1 rgf1 SPCC645.07 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38646_c2_g2_i1 Q9Y6T7 DGKB_HUMAN 1.00E-07 GO:0005524; GO:0003951; GO:0005509; GO:0005737; GO:0004143; GO:0035556; GO:0005886; GO:0030168; GO:0007205 ATP binding; NAD+ kinase activity; calcium ion binding; cytoplasm; diacylglycerol kinase activity; intracellular signal transduction; plasma membrane; platelet activation; protein kinase C-activating G-protein coupled receptor signaling pathway IPR016064; IPR000756; IPR001206; IPR011992; IPR018247; IPR002048; IPR002219; Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta) DGKB DAGK2 KIAA0718 Homo sapiens (Human) TR38646_c2_g2_i2 Q9Y6T7 DGKB_HUMAN 9.00E-08 GO:0005524; GO:0003951; GO:0005509; GO:0005737; GO:0004143; GO:0035556; GO:0005886; GO:0030168; GO:0007205 ATP binding; NAD+ kinase activity; calcium ion binding; cytoplasm; diacylglycerol kinase activity; intracellular signal transduction; plasma membrane; platelet activation; protein kinase C-activating G-protein coupled receptor signaling pathway IPR016064; IPR000756; IPR001206; IPR011992; IPR018247; IPR002048; IPR002219; Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta) DGKB DAGK2 KIAA0718 Homo sapiens (Human) TR38646_c2_g2_i3 Q7TT50 MRCKB_MOUSE 1.00E-52 GO:0005524; GO:0031532; GO:0042641; GO:0031032; GO:0031252; GO:0016477; GO:0005911; GO:0005737; GO:0035556; GO:0000287; GO:0005543; GO:0005886; GO:0004674; GO:0005083 ATP binding; actin cytoskeleton reorganization; actomyosin; actomyosin structure organization; cell leading edge; cell migration; cell-cell junction; cytoplasm; intracellular signal transduction; magnesium ion binding; phospholipid binding; plasma membrane; protein serine/threonine kinase activity; small GTPase regulator activity IPR000961; IPR001180; IPR000095; IPR020454; IPR011009; IPR014930; IPR001849; IPR002219; IPR000719; IPR017441; IPR002290; IPR008271; IPR026611; Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) Cdc42bpb Kiaa1124 Mus musculus (Mouse) TR38646_c2_g2_i4 Q3UU96 MRCKA_MOUSE 8.00E-55 GO:0005524; GO:0031532; GO:0005737; GO:0035556; GO:0046872; GO:0000226; GO:0007097; GO:0005543; GO:0004674; GO:0005083 ATP binding; actin cytoskeleton reorganization; cytoplasm; intracellular signal transduction; metal ion binding; microtubule cytoskeleton organization; nuclear migration; phospholipid binding; protein serine/threonine kinase activity; small GTPase regulator activity IPR000961; IPR001180; IPR000095; IPR011009; IPR014930; IPR011993; IPR017892; IPR001849; IPR002219; IPR000719; IPR017441; IPR002290; IPR008271; IPR026611; Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) Cdc42bpa Kiaa0451 Mus musculus (Mouse) TR38649_c2_g2_i2 Q5R9A4 DNJB9_PONAB 8.00E-14 GO:0030433; GO:0005783; GO:0005788 ER-associated protein catabolic process; endoplasmic reticulum; endoplasmic reticulum lumen IPR001623; IPR018253; DnaJ homolog subfamily B member 9 DNAJB9 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38649_c2_g2_i3 Q24331 TID_DROVI 4.00E-12 GO:0005524; GO:0046872; GO:0005741; GO:0007275; GO:0006457; GO:0009408 ATP binding; metal ion binding; mitochondrial outer membrane; multicellular organismal development; protein folding; response to heat IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; "Protein tumorous imaginal discs, mitochondrial (Protein lethal(2)tumorous imaginal discs) (TID58)" l(2)tid tid Drosophila virilis (Fruit fly) TR38649_c2_g2_i4 Q9UBS3 DNJB9_HUMAN 6.00E-14 GO:0030433; GO:0006987; GO:0005788; GO:0005789; GO:0051787; GO:0005730 ER-associated protein catabolic process; activation of signaling protein activity involved in unfolded protein response; endoplasmic reticulum lumen; endoplasmic reticulum membrane; misfolded protein binding; nucleolus IPR001623; IPR018253; DnaJ homolog subfamily B member 9 (Endoplasmic reticulum DNA J domain-containing protein 4) (ER-resident protein ERdj4) (ERdj4) (Microvascular endothelial differentiation gene 1 protein) (Mdg-1) DNAJB9 MDG1 UNQ743/PRO1471 Homo sapiens (Human) TR3865_c0_g1_i1 Q7ZVF3 DHSA_DANRE 2.00E-50 GO:0050660; GO:0005743; GO:0022904; GO:0008177; GO:0006105; GO:0006099 flavin adenine dinucleotide binding; mitochondrial inner membrane; respiratory electron transport chain; succinate dehydrogenase (ubiquinone) activity; succinate metabolic process; tricarboxylic acid cycle IPR003953; IPR003952; IPR015939; IPR027477; IPR011281; IPR014006; Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp)" sdha si:dkeyp-84f11.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR38650_c2_g2_i5 Q6PHZ5 RB15B_MOUSE 9.00E-99 GO:0003723; GO:0008380; GO:0006397; GO:0005654; GO:0000166; GO:0000381; GO:0006355; GO:0006351 "RNA binding; RNA splicing; mRNA processing; nucleoplasm; nucleotide binding; regulation of alternative mRNA splicing, via spliceosome; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR012677; IPR000504; IPR012921; IPR016194; IPR010912; Putative RNA-binding protein 15B (RNA-binding motif protein 15B) Rbm15b Mus musculus (Mouse) TR38651_c0_g1_i1 Q3US41 ESRP1_MOUSE 5.00E-168 GO:0008380; GO:0003729; GO:0006397; GO:0000166; GO:0005634; GO:0043484 RNA splicing; mRNA binding; mRNA processing; nucleotide binding; nucleus; regulation of RNA splicing IPR012677; IPR012337; IPR000504; Epithelial splicing regulatory protein 1 (RNA-binding motif protein 35A) (RNA-binding protein 35A) Esrp1 Rbm35a Mus musculus (Mouse) TR38651_c0_g1_i2 A1L1G1 ESRP1_DANRE 2.00E-171 GO:0008380; GO:0003729; GO:0006397; GO:0000166; GO:0005634; GO:0043484 RNA splicing; mRNA binding; mRNA processing; nucleotide binding; nucleus; regulation of RNA splicing IPR012677; IPR012337; IPR000504; Epithelial splicing regulatory protein 1 (RNA-binding motif protein 35A) (RNA-binding protein 35A) esrp1 rbm35a zgc:154050 Danio rerio (Zebrafish) (Brachydanio rerio) TR38655_c14_g1_i1 Q3V0B4 CC108_MOUSE 4.00E-30 GO:0016021 integral to membrane Coiled-coil domain-containing protein 108 Ccdc108 Mus musculus (Mouse) TR38655_c9_g1_i1 Q3V0B4 CC108_MOUSE 5.00E-81 GO:0016021 integral to membrane Coiled-coil domain-containing protein 108 Ccdc108 Mus musculus (Mouse) TR38656_c3_g3_i1 A4QNW7 PHIPL_DANRE 6.00E-31 IPR003961; IPR013783; Phytanoyl-CoA hydroxylase-interacting protein-like phyhipl zgc:100983 Danio rerio (Zebrafish) (Brachydanio rerio) TR38656_c3_g3_i9 Q32L96 PHIPL_BOVIN 9.00E-34 GO:0005737 cytoplasm IPR003961; IPR013783; Phytanoyl-CoA hydroxylase interacting protein-like PHYHIPL Bos taurus (Bovine) TR38658_c0_g1_i1 Q15822 ACHA2_HUMAN 3.00E-27 GO:0015464; GO:0004889; GO:0005892; GO:0030054; GO:0045211 acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 Homo sapiens (Human) TR38658_c0_g1_i2 A8WQK3 ACH1_CAEBR 7.00E-26 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha-type acr-16 acr-16 CBG01491 Caenorhabditis briggsae TR38658_c0_g1_i3 P02710 ACHA_TORCA 9.00E-19 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha CHRNA1 Torpedo californica (Pacific electric ray) TR38658_c0_g1_i5 P09479 ACHA_CHICK 9.00E-18 GO:0042166; GO:0015464; GO:0004889; GO:0005892; GO:0030054; GO:0009986; GO:0046716; GO:0031594; GO:0007528; GO:0050905; GO:0007274; GO:0070050; GO:0045211; GO:0019228; GO:0003009; GO:0048630 acetylcholine binding; acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; cell surface; muscle cell cellular homeostasis; neuromuscular junction; neuromuscular junction development; neuromuscular process; neuromuscular synaptic transmission; neuron cellular homeostasis; postsynaptic membrane; regulation of action potential in neuron; skeletal muscle contraction; skeletal muscle tissue growth IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha CHRNA1 Gallus gallus (Chicken) TR38658_c0_g1_i6 P43144 ACHA9_RAT 2.00E-26 GO:0004889; GO:0005892; GO:0005262; GO:0030054; GO:0007204; GO:0045211; GO:0007605 acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; calcium channel activity; cell junction; elevation of cytosolic calcium ion concentration; postsynaptic membrane; sensory perception of sound IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9) Chrna9 Acra9 Rattus norvegicus (Rat) TR38658_c0_g1_i8 Q07263 ACHA3_BOVIN 5.00E-23 GO:0015464; GO:0004889; GO:0005892; GO:0035095; GO:0030054; GO:0007399; GO:0045211; GO:0060084 acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; behavioral response to nicotine; cell junction; nervous system development; postsynaptic membrane; synaptic transmission involved in micturition IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 Bos taurus (Bovine) TR38658_c0_g1_i9 Q15822 ACHA2_HUMAN 1.00E-28 GO:0015464; GO:0004889; GO:0005892; GO:0030054; GO:0045211 acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 Homo sapiens (Human) TR38661_c0_g3_i1 P14315 CAPZB_CHICK 8.00E-142 GO:0008290; GO:0071203; GO:0030018; GO:0030036; GO:0051693; GO:0007010; GO:0005829; GO:0022604 F-actin capping protein complex; WASH complex; Z disc; actin cytoskeleton organization; actin filament capping; cytoskeleton organization; cytosol; regulation of cell morphogenesis IPR001698; IPR019771; F-actin-capping protein subunit beta isoforms 1 and 2 (Beta-actinin subunit II) (CapZ 36/32) (CapZ B1 and B2) CAPZB Gallus gallus (Chicken) TR38662_c2_g3_i2 Q27665 K6PF_HAECO 2.00E-11 GO:0003872; GO:0005945; GO:0005524; GO:0006002; GO:0006096 6-phosphofructokinase activity; 6-phosphofructokinase complex; ATP binding; fructose 6-phosphate metabolic process; glycolysis IPR009161; IPR022953; IPR015912; IPR000023; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. 6-phosphofructokinase (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase) PFK Haemonchus contortus (Barber pole worm) TR38663_c2_g1_i2 Q3S853 RGS2_PIG 1.00E-18 GO:0050873; GO:0007049; GO:0005829; GO:0009898; GO:0043407; GO:0010614; GO:0010519; GO:0005730; GO:0060452; GO:0071877; GO:0006417; GO:0055119; GO:0060087; GO:0007283; GO:0038032 brown fat cell differentiation; cell cycle; cytosol; internal side of plasma membrane; negative regulation of MAP kinase activity; negative regulation of cardiac muscle hypertrophy; negative regulation of phospholipase activity; nucleolus; positive regulation of cardiac muscle contraction; regulation of adrenergic receptor signaling pathway; regulation of translation; relaxation of cardiac muscle; relaxation of vascular smooth muscle; spermatogenesis; termination of G-protein coupled receptor signaling pathway IPR024066; IPR016137; IPR000342; Regulator of G-protein signaling 2 (RGS2) RGS2 Sus scrofa (Pig) TR38663_c2_g2_i2 Q9PWA0 RGS17_CHICK 2.00E-41 GO:0005096; GO:0005737; GO:0005634; GO:0005886; GO:0038032 GTPase activator activity; cytoplasm; nucleus; plasma membrane; termination of G-protein coupled receptor signaling pathway IPR024066; IPR016137; IPR000342; Regulator of G-protein signaling 17 (RGS17) RGS17 Gallus gallus (Chicken) TR38663_c2_g2_i3 Q9PWA0 RGS17_CHICK 3.00E-43 GO:0005096; GO:0005737; GO:0005634; GO:0005886; GO:0038032 GTPase activator activity; cytoplasm; nucleus; plasma membrane; termination of G-protein coupled receptor signaling pathway IPR024066; IPR016137; IPR000342; Regulator of G-protein signaling 17 (RGS17) RGS17 Gallus gallus (Chicken) TR38664_c0_g1_i4 Q08EC4 CASS4_MOUSE 2.00E-17 GO:0007155; GO:0005737; GO:0005856; GO:0005925 cell adhesion; cytoplasm; cytoskeleton; focal adhesion IPR021901; IPR014928; IPR001452; Cas scaffolding protein family member 4 Cass4 Mus musculus (Mouse) TR38664_c0_g1_i5 Q63767 BCAR1_RAT 2.00E-36 GO:0050853; GO:0007186; GO:0007015; GO:0007155; GO:0016477; GO:0005737; GO:0007173; GO:0005925; GO:0008286; GO:0007229; GO:0048011; GO:0005886; GO:0048008; GO:0030335; GO:0001726 P18031; P05480 B cell receptor signaling pathway; G-protein coupled receptor signaling pathway; actin filament organization; cell adhesion; cell migration; cytoplasm; epidermal growth factor receptor signaling pathway; focal adhesion; insulin receptor signaling pathway; integrin-mediated signaling pathway; neurotrophin TRK receptor signaling pathway; plasma membrane; platelet-derived growth factor receptor signaling pathway; positive regulation of cell migration; ruffle IPR021901; IPR014928; IPR001452; IPR013315; Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas) Bcar1 Cas Crkas Rattus norvegicus (Rat) TR38664_c0_g1_i7 Q63767 BCAR1_RAT 5.00E-16 GO:0050853; GO:0007186; GO:0007015; GO:0007155; GO:0016477; GO:0005737; GO:0007173; GO:0005925; GO:0008286; GO:0007229; GO:0048011; GO:0005886; GO:0048008; GO:0030335; GO:0001726 P18031; P05480 B cell receptor signaling pathway; G-protein coupled receptor signaling pathway; actin filament organization; cell adhesion; cell migration; cytoplasm; epidermal growth factor receptor signaling pathway; focal adhesion; insulin receptor signaling pathway; integrin-mediated signaling pathway; neurotrophin TRK receptor signaling pathway; plasma membrane; platelet-derived growth factor receptor signaling pathway; positive regulation of cell migration; ruffle IPR021901; IPR014928; IPR001452; IPR013315; Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas) Bcar1 Cas Crkas Rattus norvegicus (Rat) TR38665_c2_g1_i1 Q6I6F4 BIRC5_FELCA 3.00E-07 GO:0000086; GO:0005814; GO:0032133; GO:0007059; GO:0048037; GO:0000777; GO:0043027; GO:0000910; GO:0005881; GO:0005829; GO:0009790; GO:0051303; GO:0031021; GO:0008017; GO:0000226; GO:0030496; GO:0007067; GO:0043066; GO:0043524; GO:0045892; GO:0005634; GO:0031536; GO:0045931; GO:0031503; GO:0042803; GO:0006468; GO:0031577; GO:0005876; GO:0006351; GO:0008270 "G2/M transition of mitotic cell cycle; centriole; chromosome passenger complex; chromosome segregation; cofactor binding; condensed chromosome kinetochore; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytokinesis; cytoplasmic microtubule; cytosol; embryo development; establishment of chromosome localization; interphase microtubule organizing center; microtubule binding; microtubule cytoskeleton organization; midbody; mitosis; negative regulation of apoptotic process; negative regulation of neuron apoptotic process; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of exit from mitosis; positive regulation of mitotic cell cycle; protein complex localization; protein homodimerization activity; protein phosphorylation; spindle checkpoint; spindle microtubule; transcription, DNA-dependent; zinc ion binding" IPR001370; Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) BIRC5 Felis catus (Cat) (Felis silvestris catus) TR38665_c2_g1_i5 A1E2V0 BIRC3_CANFA 2.00E-17 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) BIRC3 Canis familiaris (Dog) (Canis lupus familiaris) TR38665_c2_g1_i6 A2AWP0 BIRC7_MOUSE 2.00E-15 GO:0005794; GO:0006915; GO:0004869; GO:0043066; GO:0005634; GO:0042127; GO:0070247; GO:0004842; GO:0008270 Golgi apparatus; apoptotic process; cysteine-type endopeptidase inhibitor activity; negative regulation of apoptotic process; nucleus; regulation of cell proliferation; regulation of natural killer cell apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; IPR017907; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (Livin) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30 kDa subunit (Truncated livin) (p30-Livin) (tLivin)] Birc7 Livin Mus musculus (Mouse) TR38665_c2_g1_i7 Q5BKL8 XIAP_XENTR 2.00E-12 GO:0016055; GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0045861; GO:0008270 Wnt receptor signaling pathway; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; negative regulation of proteolysis; zinc ion binding IPR001370; IPR001841; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (X-linked inhibitor of apoptosis protein) (X-linked IAP) xiap birc4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38666_c3_g2_i1 Q3TI53 SCHI1_MOUSE 2.00E-41 GO:0005737 P35240 cytoplasm IPR015649; Schwannomin-interacting protein 1 (SCHIP-1) Schip1 Mus musculus (Mouse) TR38673_c3_g1_i1 Q8VCL5 S17A9_MOUSE 8.00E-108 GO:0006887; GO:0016021; GO:0055085; GO:0005215 exocytosis; integral to membrane; transmembrane transport; transporter activity IPR011701; IPR020846; IPR016196; IPR005829; Solute carrier family 17 member 9 Slc17a9 Mus musculus (Mouse) TR38673_c3_g1_i4 Q8VCL5 S17A9_MOUSE 2.00E-114 GO:0006887; GO:0016021; GO:0055085; GO:0005215 exocytosis; integral to membrane; transmembrane transport; transporter activity IPR011701; IPR020846; IPR016196; IPR005829; Solute carrier family 17 member 9 Slc17a9 Mus musculus (Mouse) TR38674_c2_g1_i3 Q5REF4 F178A_PONAB 1.00E-27 IPR026161; Protein FAM178A FAM178A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38677_c1_g2_i1 Q7YW31 CTR1_OCTVU 4.00E-06 GO:0016021; GO:0005886; GO:0016500; GO:0005000 integral to membrane; plasma membrane; protein-hormone receptor activity; vasopressin receptor activity IPR000276; IPR017452; IPR001817; Cephalotocin receptor 1 (OC/CE-R 1) (OT/VP superfamily peptide receptor 1) CTR1 Octopus vulgaris (Common octopus) TR38679_c0_g2_i1 Q15042 RB3GP_HUMAN 0 GO:0005097; GO:0043010; GO:0005813; GO:0005737; GO:0060325; GO:0021854; GO:0005634 Rab GTPase activator activity; camera-type eye development; centrosome; cytoplasm; face morphogenesis; hypothalamus development; nucleus IPR026147; Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP) RAB3GAP1 KIAA0066 RAB3GAP Homo sapiens (Human) TR38679_c0_g3_i1 Q93538 RB3GP_CAEEL 1.00E-24 GO:0005097; GO:0017137; GO:0005737 Rab GTPase activator activity; Rab GTPase binding; cytoplasm IPR026147; Rab3 GTPase-activating protein catalytic subunit (Rab3 GTPase-activating protein 1) rbg-1 F20D1.6 Caenorhabditis elegans TR38679_c1_g1_i1 Q71U34 HSP7C_SAGOE 0 GO:0005524; GO:0042470 ATP binding; melanosome IPR018181; IPR013126; Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) (Intracellular vitamin D-binding protein 1) HSPA8 IDBP1 Saguinus oedipus (Cotton-top tamarin) TR38679_c1_g1_i2 P63018 HSP7C_RAT 0 GO:0043531; GO:0005524; GO:0042623; GO:0000974; GO:0008380; GO:0051085; GO:0070062; GO:0006397; GO:0042470; GO:0045892; GO:0043005; GO:0043025; GO:0005730; GO:0006950; GO:0030529; GO:0005681; GO:0008021; GO:0006351; GO:0051082 "ADP binding; ATP binding; ATPase activity, coupled; Prp19 complex; RNA splicing; chaperone mediated protein folding requiring cofactor; extracellular vesicular exosome; mRNA processing; melanosome; negative regulation of transcription, DNA-dependent; neuron projection; neuronal cell body; nucleolus; response to stress; ribonucleoprotein complex; spliceosomal complex; synaptic vesicle; transcription, DNA-dependent; unfolded protein binding" IPR018181; IPR013126; Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) Hspa8 Hsc70 Hsc73 Rattus norvegicus (Rat) TR38680_c4_g1_i2 Q8DRA5 DPO3_STRR6 4.00E-08 GO:0008408; GO:0003677; GO:0006260; GO:0003887; GO:0005737; GO:0090305 3'-5' exonuclease activity; DNA binding; DNA replication; DNA-directed DNA polymerase activity; cytoplasm; nucleic acid phosphodiester bond hydrolysis IPR011708; IPR028112; IPR024754; IPR006054; IPR006055; IPR013520; IPR012340; IPR004013; IPR003141; IPR016195; IPR006308; IPR012337; DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC spr0251 Streptococcus pneumoniae (strain ATCC BAA-255 / R6) TR38680_c4_g1_i3 Q895K2 DPO3_CLOTE 8.00E-08 GO:0008408; GO:0003677; GO:0006260; GO:0003887; GO:0005737; GO:0090305 3'-5' exonuclease activity; DNA binding; DNA replication; DNA-directed DNA polymerase activity; cytoplasm; nucleic acid phosphodiester bond hydrolysis IPR011708; IPR024754; IPR006054; IPR006055; IPR013520; IPR012340; IPR004365; IPR004013; IPR003141; IPR006308; IPR012337; DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC CTC_01271 Clostridium tetani (strain Massachusetts / E88) TR38680_c4_g1_i4 Q8DRA5 DPO3_STRR6 1.00E-07 GO:0008408; GO:0003677; GO:0006260; GO:0003887; GO:0005737; GO:0090305 3'-5' exonuclease activity; DNA binding; DNA replication; DNA-directed DNA polymerase activity; cytoplasm; nucleic acid phosphodiester bond hydrolysis IPR011708; IPR028112; IPR024754; IPR006054; IPR006055; IPR013520; IPR012340; IPR004013; IPR003141; IPR016195; IPR006308; IPR012337; DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC spr0251 Streptococcus pneumoniae (strain ATCC BAA-255 / R6) TR38682_c0_g1_i1 Q60989 XIAP_MOUSE 3.00E-18 GO:0016055; GO:0005737; GO:0005829; GO:1990001; GO:0043066; GO:0043524; GO:0051402; GO:0005634; GO:0048471; GO:0043234; GO:0004842; GO:0008270 P53702; Q9JIY5 Wnt receptor signaling pathway; cytoplasm; cytosol; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of neuron apoptotic process; neuron apoptotic process; nucleus; perinuclear region of cytoplasm; protein complex; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (mIAP-3) (mIAP3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) Xiap Aipa Api3 Birc4 Miha Mus musculus (Mouse) TR38683_c1_g1_i1 Q0DLB9 RH17_ORYSJ 5.00E-100 GO:0005524; GO:0008026; GO:0003723 ATP binding; ATP-dependent helicase activity; RNA binding IPR011545; IPR025313; IPR014001; IPR001650; IPR027417; IPR014014; DEAD-box ATP-dependent RNA helicase 17 (EC 3.6.4.13) Os05g0110500 LOC_Os05g01990 P0016H04.6 Oryza sativa subsp. japonica (Rice) TR38683_c1_g1_i2 Q869P0 DDX31_DICDI 2.00E-63 GO:0005524; GO:0008026; GO:0003723 ATP binding; ATP-dependent helicase activity; RNA binding IPR011545; IPR025313; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase ddx31 (EC 3.6.4.13) (DEAD box protein 31) ddx31 DDB_G0271708 Dictyostelium discoideum (Slime mold) TR38683_c1_g1_i3 Q86B47 Y8611_DROME 3.00E-80 GO:0005524; GO:0004004; GO:0003723 ATP binding; ATP-dependent RNA helicase activity; RNA binding IPR011545; IPR025313; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase CG8611 (EC 3.6.4.13) CG8611 Drosophila melanogaster (Fruit fly) TR38683_c1_g1_i5 Q9H8H2 DDX31_HUMAN 3.00E-179 GO:0005524; GO:0008026; GO:0003723; GO:0005730 ATP binding; ATP-dependent helicase activity; RNA binding; nucleolus IPR011545; IPR025313; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX31 (EC 3.6.4.13) (DEAD box protein 31) (Helicain) DDX31 Homo sapiens (Human) TR38684_c1_g1_i1 Q8BMT9 HHAT_MOUSE 4.00E-54 GO:0005525; GO:0005789; GO:0016021; GO:0007275; GO:0016409; GO:0018345; GO:0007224 GTP binding; endoplasmic reticulum membrane; integral to membrane; multicellular organismal development; palmitoyltransferase activity; protein palmitoylation; smoothened signaling pathway IPR004299; Protein-cysteine N-palmitoyltransferase HHAT (EC 2.3.1.-) (Hedgehog acyltransferase) (Skinny hedgehog protein) Hhat Skn Mus musculus (Mouse) TR38684_c1_g1_i2 Q8BMT9 HHAT_MOUSE 4.00E-54 GO:0005525; GO:0005789; GO:0016021; GO:0007275; GO:0016409; GO:0018345; GO:0007224 GTP binding; endoplasmic reticulum membrane; integral to membrane; multicellular organismal development; palmitoyltransferase activity; protein palmitoylation; smoothened signaling pathway IPR004299; Protein-cysteine N-palmitoyltransferase HHAT (EC 2.3.1.-) (Hedgehog acyltransferase) (Skinny hedgehog protein) Hhat Skn Mus musculus (Mouse) TR38688_c0_g1_i1 Q5RKJ1 MAEA_RAT 4.00E-163 GO:0005826; GO:0007155; GO:0007049; GO:0051301; GO:0007010; GO:0048822; GO:0043249; GO:0005887; GO:0033033; GO:0016363; GO:0005819 actomyosin contractile ring; cell adhesion; cell cycle; cell division; cytoskeleton organization; enucleate erythrocyte development; erythrocyte maturation; integral to plasma membrane; negative regulation of myeloid cell apoptotic process; nuclear matrix; spindle IPR013144; IPR024964; IPR006595; IPR006594; Macrophage erythroblast attacher Maea Rattus norvegicus (Rat) TR38689_c1_g2_i1 Q6WRH9 IGS10_RAT 1.00E-13 GO:0030154; GO:0005576; GO:0007275; GO:0001503; GO:0042246 cell differentiation; extracellular region; multicellular organismal development; ossification; tissue regeneration IPR000483; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR003591; IPR000372; Immunoglobulin superfamily member 10 (IgSF10) (Calvaria mechanical force protein 608) (CMF608) Igsf10 Cmf608 Rattus norvegicus (Rat) TR38689_c1_g2_i2 O75473 LGR5_HUMAN 3.00E-22 GO:0004930; GO:0005794; GO:0048839; GO:0005887; GO:0090263; GO:0032588 G-protein coupled receptor activity; Golgi apparatus; inner ear development; integral to plasma membrane; positive regulation of canonical Wnt receptor signaling pathway; trans-Golgi network membrane IPR000276; IPR017452; IPR002131; IPR001611; IPR003591; IPR000372; IPR026906; Leucine-rich repeat-containing G-protein coupled receptor 5 (G-protein coupled receptor 49) (G-protein coupled receptor 67) (G-protein coupled receptor HG38) LGR5 GPR49 GPR67 Homo sapiens (Human) TR38690_c2_g2_i1 Q174D3 MED19_AEDAE 2.00E-45 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR019403; Mediator of RNA polymerase II transcription subunit 19 (Mediator complex subunit 19) MED19 AAEL006934 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR38690_c2_g2_i4 Q174D3 MED19_AEDAE 3.00E-45 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR019403; Mediator of RNA polymerase II transcription subunit 19 (Mediator complex subunit 19) MED19 AAEL006934 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR38691_c2_g1_i2 Q9P7R8 YHV3_SCHPO 1.00E-38 GO:0005086; GO:0006888; GO:0005794; GO:0000139; GO:0043001; GO:0030036; GO:0005829; GO:0016021; GO:0032012 ARF guanyl-nucleotide exchange factor activity; ER to Golgi vesicle-mediated transport; Golgi apparatus; Golgi membrane; Golgi to plasma membrane protein transport; actin cytoskeleton organization; cytosol; integral to membrane; regulation of ARF protein signal transduction IPR016024; IPR023394; IPR000904; Uncharacterized protein C211.03 SPBC211.03c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38691_c2_g4_i1 Q92538 GBF1_HUMAN 1.00E-154 GO:0005086; GO:0048205; GO:0000139; GO:0005795; GO:0005801; GO:0005788; GO:0005739; GO:0019048; GO:0005777; GO:0006892; GO:0032012; GO:0006890; GO:0005802 P53620; Q9Y678 "ARF guanyl-nucleotide exchange factor activity; COPI coating of Golgi vesicle; Golgi membrane; Golgi stack; cis-Golgi network; endoplasmic reticulum lumen; mitochondrion; modulation by virus of host morphology or physiology; peroxisome; post-Golgi vesicle-mediated transport; regulation of ARF protein signal transduction; retrograde vesicle-mediated transport, Golgi to ER; trans-Golgi network" IPR016024; IPR023394; IPR000904; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) GBF1 KIAA0248 Homo sapiens (Human) TR38691_c3_g1_i1 Q9R1D7 GBF1_CRIGR 2.00E-46 GO:0005086; GO:0032012 ARF guanyl-nucleotide exchange factor activity; regulation of ARF protein signal transduction IPR016024; IPR023394; IPR000904; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) GBF1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR38692_c5_g1_i1 Q7M3Y3 TNNI_CHLNI 3.00E-26 GO:0046872; GO:0005861 metal ion binding; troponin complex IPR001978; Troponin I (TnI) Chlamys nipponensis akazara (Akazara scallop) (Japanese scallop) TR38692_c5_g1_i6 P05547 TNNI_PONLE 7.00E-09 GO:0046872; GO:0005861 metal ion binding; troponin complex IPR001978; Troponin I (TnI) Astacus leptodactylus (Turkish narrow-clawed crayfish) (Pontastacus leptodactylus) TR38692_c5_g1_i7 Q7M3Y3 TNNI_CHLNI 2.00E-25 GO:0046872; GO:0005861 metal ion binding; troponin complex IPR001978; Troponin I (TnI) Chlamys nipponensis akazara (Akazara scallop) (Japanese scallop) TR38693_c2_g1_i1 P31674 RS15_ORYSJ 6.00E-82 GO:0003723; GO:0015935; GO:0003735; GO:0006412 RNA binding; small ribosomal subunit; structural constituent of ribosome; translation IPR002222; IPR020934; IPR023575; IPR005713; 40S ribosomal protein S15 RPS15 Os07g0184300 LOC_Os07g08660 OJ1046_F10.119 Oryza sativa subsp. japonica (Rice) TR38693_c3_g2_i1 P15870 H1D_STRPU 4.00E-16 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR005818; IPR005819; IPR011991; Histone H1-delta Strongylocentrotus purpuratus (Purple sea urchin) TR38693_c4_g2_i1 P74125 Y1880_SYNY3 6.00E-27 IPR001602; UPF0047 protein sll1880 sll1880 Synechocystis sp. (strain PCC 6803 / Kazusa) TR38693_c4_g2_i2 P0AF48 YJBQ_ECOLI 3.00E-41 IPR001602; UPF0047 protein YjbQ yjbQ b4056 JW4017 Escherichia coli (strain K12) TR38694_c1_g3_i3 B2GUY0 MA1B1_RAT 0 GO:0030433; GO:0005509; GO:0005789; GO:0016021; GO:0004571; GO:0006486 "ER-associated protein catabolic process; calcium ion binding; endoplasmic reticulum membrane; integral to membrane; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; protein glycosylation" IPR001382; Protein modification; protein glycosylation. "Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Mannosidase alpha class 1B member 1)" Man1b1 Rattus norvegicus (Rat) TR38695_c0_g2_i1 A8Y1P7 BRE4_CAEBR 3.00E-53 GO:0016021; GO:0046872; GO:0006486; GO:0016757 "integral to membrane; metal ion binding; protein glycosylation; transferase activity, transferring glycosyl groups" IPR003859; IPR027791; IPR027995; Protein modification; protein glycosylation. "Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.-) (Bacillus thuringiensis toxin-resistant protein 4) (Bt toxin-resistant protein 4) (Beta-4-GalNAcT)" bre-4 CBG22165 Caenorhabditis briggsae TR38695_c0_g4_i1 Q09323 BAGT_LYMST 3.00E-32 GO:0000139; GO:0016021; GO:0006486; GO:0016757 "Golgi membrane; integral to membrane; protein glycosylation; transferase activity, transferring glycosyl groups" IPR003859; IPR027791; IPR027995; Protein modification; protein glycosylation. "Beta-N-acetyl-D-glucosaminide beta-1,4-N-acetylglucosaminyl-transferase (EC 2.4.1.-) (Beta-1,4-GlcNAcT) (UDP-GlcNAc:GlcNAc beta-R beta-1,4-N-acetylglucosaminyl-transferase)" GNT Lymnaea stagnalis (Great pond snail) TR38696_c1_g2_i1 P70392 RGRF2_MOUSE 2.00E-21 GO:0005089; GO:0005789; GO:0005543; GO:0005886; GO:0035023; GO:0007264 Rho guanyl-nucleotide exchange factor activity; endoplasmic reticulum membrane; phospholipid binding; plasma membrane; regulation of Rho protein signal transduction; small GTPase mediated signal transduction IPR000219; IPR000048; IPR011993; IPR001849; IPR000651; IPR019804; IPR008937; IPR023578; IPR001895; Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) Rasgrf2 Grf2 Mus musculus (Mouse) TR38696_c1_g2_i2 Q9NZL6 RGL1_HUMAN 4.00E-131 GO:0008321; GO:0044255; GO:0005829; GO:0051056; GO:0007264; GO:0044281 Ral guanyl-nucleotide exchange factor activity; cellular lipid metabolic process; cytosol; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; small molecule metabolic process IPR000159; IPR000651; IPR019804; IPR008937; IPR023578; IPR001895; Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) RGL1 KIAA0959 RGL Homo sapiens (Human) TR38698_c0_g1_i1 Q9CY21 WBS22_MOUSE 6.00E-109 GO:0008168; GO:0005634 methyltransferase activity; nucleus IPR013216; IPR022238; Ribosome biogenesis methyltransferase WBSCR22 (EC 2.1.1.-) (Williams-Beuren syndrome chromosomal region 22 protein homolog) Wbscr22 Mus musculus (Mouse) TR38698_c0_g1_i2 Q58DP0 WBS22_BOVIN 2.00E-111 GO:0008168; GO:0005634 methyltransferase activity; nucleus IPR013216; IPR022238; Ribosome biogenesis methyltransferase WBSCR22 (EC 2.1.1.-) (Williams-Beuren syndrome chromosomal region 22 protein homolog) WBSCR22 Bos taurus (Bovine) TR38698_c0_g1_i3 Q9CY21 WBS22_MOUSE 2.00E-111 GO:0008168; GO:0005634 methyltransferase activity; nucleus IPR013216; IPR022238; Ribosome biogenesis methyltransferase WBSCR22 (EC 2.1.1.-) (Williams-Beuren syndrome chromosomal region 22 protein homolog) Wbscr22 Mus musculus (Mouse) TR38700_c0_g1_i1 B4MRZ8 EIF3C_DROWI 1.00E-38 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0006446; GO:0003743 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; regulation of translational initiation; translation initiation factor activity IPR027516; IPR008905; IPR000717; IPR011991; Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) eIF3-S8 GK15661 Drosophila willistoni (Fruit fly) TR38700_c1_g2_i1 Q9QXT0 CNPY2_MOUSE 1.00E-21 GO:0005783; GO:0010629; GO:0045716; GO:0010988 endoplasmic reticulum; negative regulation of gene expression; positive regulation of low-density lipoprotein particle receptor biosynthetic process; regulation of low-density lipoprotein particle clearance IPR021852; IPR008139; Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein ZSIG9) (Transmembrane protein 4) Cnpy2 Msap Tmem4 Zsig9 Mus musculus (Mouse) TR38701_c0_g1_i1 Q68CZ1 FTM_HUMAN 2.00E-64 GO:0043010; GO:0005911; GO:0005813; GO:0021549; GO:0042384; GO:0035085; GO:0022038; GO:0007368; GO:0035115; GO:0035116; GO:0007163; GO:0060322; GO:0001701; GO:0001822; GO:0021670; GO:0001889; GO:0005932; GO:0045744; GO:0021532; GO:0043584; GO:0021772; GO:0060039; GO:0008589; GO:0005923 camera-type eye development; cell-cell junction; centrosome; cerebellum development; cilium assembly; cilium axoneme; corpus callosum development; determination of left/right symmetry; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; establishment or maintenance of cell polarity; head development; in utero embryonic development; kidney development; lateral ventricle development; liver development; microtubule basal body; negative regulation of G-protein coupled receptor protein signaling pathway; neural tube patterning; nose development; olfactory bulb development; pericardium development; regulation of smoothened signaling pathway; tight junction IPR000008; IPR021656; Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein) RPGRIP1L FTM KIAA1005 NPHP8 Homo sapiens (Human) TR38701_c0_g1_i3 Q68CZ1 FTM_HUMAN 1.00E-64 GO:0043010; GO:0005911; GO:0005813; GO:0021549; GO:0042384; GO:0035085; GO:0022038; GO:0007368; GO:0035115; GO:0035116; GO:0007163; GO:0060322; GO:0001701; GO:0001822; GO:0021670; GO:0001889; GO:0005932; GO:0045744; GO:0021532; GO:0043584; GO:0021772; GO:0060039; GO:0008589; GO:0005923 camera-type eye development; cell-cell junction; centrosome; cerebellum development; cilium assembly; cilium axoneme; corpus callosum development; determination of left/right symmetry; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; establishment or maintenance of cell polarity; head development; in utero embryonic development; kidney development; lateral ventricle development; liver development; microtubule basal body; negative regulation of G-protein coupled receptor protein signaling pathway; neural tube patterning; nose development; olfactory bulb development; pericardium development; regulation of smoothened signaling pathway; tight junction IPR000008; IPR021656; Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein) RPGRIP1L FTM KIAA1005 NPHP8 Homo sapiens (Human) TR38702_c1_g1_i1 Q9R1D7 GBF1_CRIGR 4.00E-124 GO:0005086; GO:0032012 ARF guanyl-nucleotide exchange factor activity; regulation of ARF protein signal transduction IPR016024; IPR023394; IPR000904; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) GBF1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR38702_c1_g1_i2 Q92538 GBF1_HUMAN 3.00E-122 GO:0005086; GO:0048205; GO:0000139; GO:0005795; GO:0005801; GO:0005788; GO:0005739; GO:0019048; GO:0005777; GO:0006892; GO:0032012; GO:0006890; GO:0005802 P53620; Q9Y678 "ARF guanyl-nucleotide exchange factor activity; COPI coating of Golgi vesicle; Golgi membrane; Golgi stack; cis-Golgi network; endoplasmic reticulum lumen; mitochondrion; modulation by virus of host morphology or physiology; peroxisome; post-Golgi vesicle-mediated transport; regulation of ARF protein signal transduction; retrograde vesicle-mediated transport, Golgi to ER; trans-Golgi network" IPR016024; IPR023394; IPR000904; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) GBF1 KIAA0248 Homo sapiens (Human) TR38702_c1_g1_i3 Q92538 GBF1_HUMAN 8.00E-118 GO:0005086; GO:0048205; GO:0000139; GO:0005795; GO:0005801; GO:0005788; GO:0005739; GO:0019048; GO:0005777; GO:0006892; GO:0032012; GO:0006890; GO:0005802 P53620; Q9Y678 "ARF guanyl-nucleotide exchange factor activity; COPI coating of Golgi vesicle; Golgi membrane; Golgi stack; cis-Golgi network; endoplasmic reticulum lumen; mitochondrion; modulation by virus of host morphology or physiology; peroxisome; post-Golgi vesicle-mediated transport; regulation of ARF protein signal transduction; retrograde vesicle-mediated transport, Golgi to ER; trans-Golgi network" IPR016024; IPR023394; IPR000904; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) GBF1 KIAA0248 Homo sapiens (Human) TR38704_c1_g1_i1 Q96LI9 CX058_HUMAN 2.00E-65 Putative uncharacterized protein CXorf58 CXorf58 Homo sapiens (Human) TR38705_c1_g1_i1 Q27712 CP2L1_PANAR 3.00E-07 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 2L1 (EC 1.14.14.1) (CYPIIL1) CYP2L1 Panulirus argus (Caribbean spiny lobster) (Palinurus argus) TR38705_c1_g2_i1 O73853 CP17A_ICTPU 3.00E-30 GO:0047442; GO:0020037; GO:0005506; GO:0016020; GO:0004508; GO:0006694 17-alpha-hydroxyprogesterone aldolase activity; heme binding; iron ion binding; membrane; steroid 17-alpha-monooxygenase activity; steroid biosynthetic process IPR001128; IPR017972; IPR002401; Lipid metabolism; steroid biosynthesis. "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.99.9) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" cyp17a1 cyp17 Ictalurus punctatus (Channel catfish) (Silurus punctatus) TR38706_c1_g1_i3 Q6FFY1 UBIG_ACIAD 3.00E-09 GO:0008425; GO:0008689; GO:0006744 "2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; 3-demethylubiquinone-9 3-O-methyltransferase activity; ubiquinone biosynthetic process" IPR010233; Cofactor biosynthesis; ubiquinone biosynthesis. Ubiquinone biosynthesis O-methyltransferase (2-polyprenyl-6-hydroxyphenol methylase) (EC 2.1.1.222) (3-demethylubiquinone 3-O-methyltransferase) (EC 2.1.1.64) ubiG ACIAD0044 Acinetobacter sp. (strain ADP1) TR38707_c1_g1_i1 P40994 ARF3_YEAST 8.00E-09 GO:0005525; GO:0003924; GO:0005794; GO:0051666; GO:0051017; GO:0005935; GO:0000282; GO:0005934; GO:0006897; GO:0006886; GO:0003729; GO:0010513; GO:0007264 P25369 GTP binding; GTPase activity; Golgi apparatus; actin cortical patch localization; actin filament bundle assembly; cellular bud neck; cellular bud site selection; cellular bud tip; endocytosis; intracellular protein transport; mRNA binding; positive regulation of phosphatidylinositol biosynthetic process; small GTPase mediated signal transduction IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor 3 ARF3 YOR094W YOR3172W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR38707_c1_g1_i2 P30682 GNAI_LYMST 0 GO:0005525; GO:0003924; GO:0007188; GO:0046872; GO:0004871 GTP binding; GTPase activity; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; metal ion binding; signal transducer activity IPR001408; IPR001019; IPR011025; IPR027417; Guanine nucleotide-binding protein G(i) subunit alpha (Adenylate cyclase-inhibiting G alpha protein) Lymnaea stagnalis (Great pond snail) TR38707_c1_g2_i1 Q60397 GNAI3_CRIGR 2.00E-32 GO:0005525; GO:0003924; GO:0007188; GO:0007049; GO:0051301; GO:0005813; GO:0005737; GO:0030496; GO:0005886; GO:0004871 GTP binding; GTPase activity; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; cell cycle; cell division; centrosome; cytoplasm; midbody; plasma membrane; signal transducer activity IPR001408; IPR001019; IPR027417; Guanine nucleotide-binding protein G(k) subunit alpha (G(i) alpha-3) (Fragment) GNAI3 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR38708_c1_g2_i1 A8MQB9 YR007_HUMAN 9.00E-07 IPR002110; IPR020683; Putative ankyrin repeat domain-containing protein ENSP00000330211 Homo sapiens (Human) TR38708_c1_g3_i3 Q09YG9 CTTB2_SAIBB 2.00E-20 GO:0005938; GO:0043197 cell cortex; dendritic spine IPR002110; IPR020683; IPR019131; Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Saimiri boliviensis boliviensis (Bolivian squirrel monkey) TR38708_c1_g3_i4 Q09YM8 CTTB2_RABIT 2.00E-19 GO:0005938; GO:0043197 cell cortex; dendritic spine IPR002110; IPR020683; IPR019131; Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Oryctolagus cuniculus (Rabbit) TR38708_c1_g3_i5 Q07DY4 CTTB2_COLGU 2.00E-19 GO:0005938; GO:0043197 cell cortex; dendritic spine IPR002110; IPR020683; IPR019131; Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Colobus guereza (Mantled guereza) (Eastern black-and-white colobus monkey) TR38708_c1_g4_i1 Q8VE42 ANR49_MOUSE 3.00E-15 GO:0045893 "positive regulation of transcription, DNA-dependent" IPR002110; IPR020683; Ankyrin repeat domain-containing protein 49 (Fetal globin-increasing factor) (Fetal globin-inducing factor) Ankrd49 Fgif Gbif Mus musculus (Mouse) TR38708_c1_g4_i2 Q07DZ5 CTTB2_ORNAN 5.00E-19 GO:0005938; GO:0043197 cell cortex; dendritic spine IPR002110; IPR020683; IPR019131; Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Ornithorhynchus anatinus (Duckbill platypus) TR38708_c1_g4_i3 Q5ZMD2 ANKY2_CHICK 4.00E-07 GO:0005929; GO:0046872 cilium; metal ion binding IPR002110; IPR020683; IPR002893; Ankyrin repeat and MYND domain-containing protein 2 ANKMY2 RCJMB04_2i2 Gallus gallus (Chicken) TR38708_c1_g4_i4 Q91ZA8 NRARP_MOUSE 1.00E-07 GO:0002043; GO:1902367; GO:0045581; GO:0000122; GO:0001569; GO:0090263; GO:0001938; GO:0022407; GO:0032525 blood vessel endothelial cell proliferation involved in sprouting angiogenesis; negative regulation of Notch signaling pathway involved in somitogenesis; negative regulation of T cell differentiation; negative regulation of transcription from RNA polymerase II promoter; patterning of blood vessels; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of endothelial cell proliferation; regulation of cell-cell adhesion; somite rostral/caudal axis specification IPR002110; IPR020683; Notch-regulated ankyrin repeat-containing protein Nrarp Mus musculus (Mouse) TR38708_c1_g4_i5 G5E8K5 ANK3_MOUSE 1.00E-35 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR3871_c0_g1_i1 P98164 LRP2_HUMAN 2.00E-24 GO:0005794; GO:0016324; GO:0031526; GO:0005509; GO:0008283; GO:0005905; GO:0030139; GO:0005783; GO:0005768; GO:0030900; GO:0016021; GO:0005765; GO:0007603; GO:0006486; GO:0006898; GO:0001523; GO:0042359 "Golgi apparatus; apical plasma membrane; brush border membrane; calcium ion binding; cell proliferation; coated pit; endocytic vesicle; endoplasmic reticulum; endosome; forebrain development; integral to membrane; lysosomal membrane; phototransduction, visible light; protein glycosylation; receptor-mediated endocytosis; retinoid metabolic process; vitamin D metabolic process" IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; IPR019825; Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) LRP2 Homo sapiens (Human) TR3871_c0_g2_i1 Q04833 LRP_CAEEL 7.00E-31 GO:0016324; GO:0005509; GO:0005905; GO:0042395; GO:0030139; GO:0006897; GO:0016021; GO:0002119; GO:0040017; GO:0040018; GO:0030334; GO:0015248 "apical plasma membrane; calcium ion binding; coated pit; ecdysis, collagen and cuticulin-based cuticle; endocytic vesicle; endocytosis; integral to membrane; nematode larval development; positive regulation of locomotion; positive regulation of multicellular organism growth; regulation of cell migration; sterol transporter activity" IPR011042; IPR000742; IPR001881; IPR013032; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein (LRP) lrp-1 F29D11.1 Caenorhabditis elegans TR38712_c0_g1_i3 P18503 CAS4_EPHMU 8.00E-11 GO:0005581 collagen IPR008160; Short-chain collagen C4 (Fragment) Ephydatia muelleri (Mueller's freshwater sponge) TR38714_c4_g1_i2 Q4U2R1 HERC2_MOUSE 4.00E-09 GO:0006281; GO:0032183; GO:0005814; GO:0020037; GO:0005743; GO:0005634; GO:0042787; GO:0007283; GO:0004842; GO:0008270 DNA repair; SUMO binding; centriole; heme binding; mitochondrial inner membrane; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; spermatogenesis; ubiquitin-protein ligase activity; zinc ion binding IPR004939; IPR006624; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) Herc2 Jdf2 Kiaa0393 Rjs Mus musculus (Mouse) TR38714_c4_g1_i4 O95714 HERC2_HUMAN 2.00E-06 GO:0006281; GO:0032183; GO:0005814; GO:0005737; GO:0005085; GO:0020037; GO:0006886; GO:0005634; GO:0042787; GO:0004842; GO:0008270 DNA repair; SUMO binding; centriole; cytoplasm; guanyl-nucleotide exchange factor activity; heme binding; intracellular protein transport; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR004939; IPR006624; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) HERC2 Homo sapiens (Human) TR38718_c0_g2_i1 Q6RY07 CHIA_RAT 5.00E-126 GO:0006915; GO:0008061; GO:0006032; GO:0004568; GO:0005737; GO:0005615; GO:0000272; GO:0090197; GO:0002532 apoptotic process; chitin binding; chitin catabolic process; chitinase activity; cytoplasm; extracellular space; polysaccharide catabolic process; positive regulation of chemokine secretion; production of molecular mediator involved in inflammatory response IPR002557; IPR011583; IPR001223; IPR001579; IPR013781; IPR017853; Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) Chia Rattus norvegicus (Rat) TR38721_c0_g1_i2 Q5U3A7 OPA1_DANRE 0 GO:0005525; GO:0006184; GO:0003924; GO:0006915; GO:0009790; GO:0016021; GO:0008053; GO:0005743; GO:0005758; GO:0070584 GTP binding; GTP catabolic process; GTPase activity; apoptotic process; embryo development; integral to membrane; mitochondrial fusion; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion morphogenesis IPR001401; IPR022812; IPR027740; IPR027417; "Dynamin-like 120 kDa protein, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1 homolog) [Cleaved into: Dynamin-like 120 kDa protein, form S1]" opa1 zgc:92092 Danio rerio (Zebrafish) (Brachydanio rerio) TR38721_c0_g1_i5 Q5F499 OPA1_CHICK 0 GO:0005525; GO:0006184; GO:0003924; GO:0006915; GO:0016021; GO:0008053; GO:0005743; GO:0005758 GTP binding; GTP catabolic process; GTPase activity; apoptotic process; integral to membrane; mitochondrial fusion; mitochondrial inner membrane; mitochondrial intermembrane space IPR001401; IPR022812; IPR027740; IPR027417; "Dynamin-like 120 kDa protein, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1 homolog) [Cleaved into: Dynamin-like 120 kDa protein, form S1]" OPA1 RCJMB04_1m16 Gallus gallus (Chicken) TR38721_c0_g1_i6 P42697 DRP1A_ARATH 2.00E-30 GO:0005525; GO:0003924; GO:0009504; GO:0009920; GO:0009535; GO:0030276; GO:0072583; GO:0005829; GO:0009793; GO:0005874; GO:0009524; GO:0005886; GO:0009506; GO:0010091; GO:0005774; GO:0010051 Q5W7F2; Q9C5U2; Q9LQ55 GTP binding; GTPase activity; cell plate; cell plate formation involved in plant-type cell wall biogenesis; chloroplast thylakoid membrane; clathrin binding; clathrin-mediated endocytosis; cytosol; embryo development ending in seed dormancy; microtubule; phragmoplast; plasma membrane; plasmodesma; trichome branching; vacuolar membrane; xylem and phloem pattern formation IPR000375; IPR001401; IPR019762; IPR022812; IPR003130; IPR020850; IPR027417; Dynamin-related protein 1A (Dynamin-like protein 1) (Dynamin-like protein A) DRP1A ADL1 ADL1A AG68 At5g42080 MJC20.19 Arabidopsis thaliana (Mouse-ear cress) TR38723_c0_g1_i1 P57080 UBP25_MOUSE 1.00E-70 GO:0005737; GO:0005634; GO:0000502; GO:0071108; GO:0070536; GO:0004221; GO:0006511; GO:0004843 cytoplasm; nucleus; proteasome complex; protein K48-linked deubiquitination; protein K63-linked deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR018200; IPR001394; IPR009060; IPR003903; Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) (mUSP25) Usp25 Mus musculus (Mouse) TR38723_c0_g2_i2 Q5I043 UBP28_MOUSE 8.00E-30 GO:0000077; GO:0006281; GO:0008283; GO:0034644; GO:0042771; GO:0005730; GO:0005654; GO:0043234; GO:0016579; GO:0010212; GO:0004221; GO:0006511; GO:0004843 DNA damage checkpoint; DNA repair; cell proliferation; cellular response to UV; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; nucleolus; nucleoplasm; protein complex; protein deubiquitination; response to ionizing radiation; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR018200; IPR001394; IPR009060; IPR003903; Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) Usp28 Kiaa1515 Mus musculus (Mouse) TR38723_c0_g2_i4 P57080 UBP25_MOUSE 9.00E-24 GO:0005737; GO:0005634; GO:0000502; GO:0071108; GO:0070536; GO:0004221; GO:0006511; GO:0004843 cytoplasm; nucleus; proteasome complex; protein K48-linked deubiquitination; protein K63-linked deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR018200; IPR001394; IPR009060; IPR003903; Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) (mUSP25) Usp25 Mus musculus (Mouse) TR38723_c0_g3_i1 P57080 UBP25_MOUSE 8.00E-132 GO:0005737; GO:0005634; GO:0000502; GO:0071108; GO:0070536; GO:0004221; GO:0006511; GO:0004843 cytoplasm; nucleus; proteasome complex; protein K48-linked deubiquitination; protein K63-linked deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR018200; IPR001394; IPR009060; IPR003903; Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) (mUSP25) Usp25 Mus musculus (Mouse) TR38723_c0_g3_i2 Q09931 UBPY_CAEEL 8.00E-12 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Probable ubiquitin carboxyl-terminal hydrolase K02C4.3 (EC 3.4.19.12) (Deubiquitinating enzyme) (Ubiquitin thioesterase) (Ubiquitin-specific-processing protease) K02C4.3 Caenorhabditis elegans TR38725_c2_g1_i1 Q9Y450 HBS1L_HUMAN 0 GO:0005525; GO:0006184; GO:0003924; GO:0007165; GO:0006412; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; signal transduction; translation; translation elongation factor activity IPR000795; IPR015033; IPR027417; IPR009000; IPR009001; IPR004161; IPR004160; HBS1-like protein (ERFS) HBS1L HBS1 KIAA1038 Homo sapiens (Human) TR38725_c2_g1_i3 Q69ZS7 HBS1L_MOUSE 2.00E-23 GO:0005525; GO:0006184; GO:0003924; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; translation elongation factor activity IPR000795; IPR015033; IPR027417; IPR009000; IPR009001; IPR004161; IPR004160; HBS1-like protein Hbs1l Hbs1 Kiaa1038 Mus musculus (Mouse) TR38726_c0_g1_i1 Q5RFF8 NLE1_PONAB 9.00E-10 GO:0005730 nucleolus IPR020472; IPR001632; IPR012972; IPR015943; IPR001680; IPR019775; IPR017986; Notchless protein homolog 1 NLE1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38726_c1_g4_i3 Q3UGF1 WDR19_MOUSE 0 GO:0060830; GO:0042384; GO:0005737; GO:0055123; GO:0042471; GO:0031076; GO:0048701; GO:0030326; GO:0001701; GO:0035721; GO:0030991; GO:0005932; GO:0031514; GO:0061055; GO:0050877; GO:0032391; GO:0060831 ciliary receptor clustering involved in smoothened signaling pathway; cilium assembly; cytoplasm; digestive system development; ear morphogenesis; embryonic camera-type eye development; embryonic cranial skeleton morphogenesis; embryonic limb morphogenesis; in utero embryonic development; intraflagellar retrograde transport; intraflagellar transport particle A; microtubule basal body; motile cilium; myotome development; neurological system process; photoreceptor connecting cilium; smoothened signaling pathway involved in dorsal/ventral neural tube patterning IPR011990; IPR015943; IPR001680; IPR017986; WD repeat-containing protein 19 Wdr19 Kiaa1638 Mus musculus (Mouse) TR38726_c1_g4_i4 Q3UGF1 WDR19_MOUSE 0 GO:0060830; GO:0042384; GO:0005737; GO:0055123; GO:0042471; GO:0031076; GO:0048701; GO:0030326; GO:0001701; GO:0035721; GO:0030991; GO:0005932; GO:0031514; GO:0061055; GO:0050877; GO:0032391; GO:0060831 ciliary receptor clustering involved in smoothened signaling pathway; cilium assembly; cytoplasm; digestive system development; ear morphogenesis; embryonic camera-type eye development; embryonic cranial skeleton morphogenesis; embryonic limb morphogenesis; in utero embryonic development; intraflagellar retrograde transport; intraflagellar transport particle A; microtubule basal body; motile cilium; myotome development; neurological system process; photoreceptor connecting cilium; smoothened signaling pathway involved in dorsal/ventral neural tube patterning IPR011990; IPR015943; IPR001680; IPR017986; WD repeat-containing protein 19 Wdr19 Kiaa1638 Mus musculus (Mouse) TR38727_c1_g1_i1 Q803W1 SCRN3_DANRE 1.00E-104 GO:0016805; GO:0006508 dipeptidase activity; proteolysis IPR005322; Secernin-3 scrn3 zgc:55430 Danio rerio (Zebrafish) (Brachydanio rerio) TR38728_c10_g1_i1 O00522 KRIT1_HUMAN 5.00E-10 GO:0001525; GO:0045454; GO:0005911; GO:0005737; GO:0005874; GO:0008017; GO:0016525; GO:2000352; GO:0010596; GO:0001937; GO:0005546; GO:0005886; GO:0032092; GO:2000114; GO:0007264; GO:0005083 Q9BSQ5 "angiogenesis; cell redox homeostasis; cell-cell junction; cytoplasm; microtubule; microtubule binding; negative regulation of angiogenesis; negative regulation of endothelial cell apoptotic process; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; phosphatidylinositol-4,5-bisphosphate binding; plasma membrane; positive regulation of protein binding; regulation of establishment of cell polarity; small GTPase mediated signal transduction; small GTPase regulator activity" IPR002110; IPR020683; IPR019749; IPR014352; IPR019748; IPR000299; Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein) KRIT1 CCM1 Homo sapiens (Human) TR38728_c4_g1_i1 Q6TNJ1 KRIT1_BOVIN 3.00E-11 GO:0001525; GO:0005911; GO:0005737; GO:0005874; GO:0008017; GO:0016525; GO:2000352; GO:0010596; GO:0001937; GO:0005546; GO:0005886; GO:2000114 "angiogenesis; cell-cell junction; cytoplasm; microtubule; microtubule binding; negative regulation of angiogenesis; negative regulation of endothelial cell apoptotic process; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; phosphatidylinositol-4,5-bisphosphate binding; plasma membrane; regulation of establishment of cell polarity" IPR002110; IPR020683; IPR019749; IPR014352; IPR019748; IPR000299; Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog) KRIT1 CCM1 Bos taurus (Bovine) TR38729_c0_g1_i10 Q23157 INX11_CAEEL 2.00E-07 GO:0005921; GO:0055077; GO:0016021; GO:0006811; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transport; plasma membrane IPR000990; Innexin-11 (Protein opu-11) inx-11 opu-11 W04D2.3 Caenorhabditis elegans TR38729_c0_g1_i11 Q03412 UNC7_CAEEL 6.00E-10 GO:0005921; GO:0016264; GO:0055077; GO:0016021; GO:0034220; GO:0040011; GO:0032589; GO:0018991; GO:0043051; GO:0042221 gap junction; gap junction assembly; gap junction hemi-channel activity; integral to membrane; ion transmembrane transport; locomotion; neuron projection membrane; oviposition; regulation of pharyngeal pumping; response to chemical stimulus IPR000990; Innexin unc-7 (Uncoordinated protein 7) unc-7 unc-12 unc-124 R07D5.1 Caenorhabditis elegans TR38729_c0_g1_i12 Q23157 INX11_CAEEL 1.00E-07 GO:0005921; GO:0055077; GO:0016021; GO:0006811; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transport; plasma membrane IPR000990; Innexin-11 (Protein opu-11) inx-11 opu-11 W04D2.3 Caenorhabditis elegans TR38729_c0_g1_i2 O61715 INX19_CAEEL 1.00E-09 GO:0019855; GO:0030154; GO:0035545; GO:0005921; GO:0055077; GO:0051390; GO:0016021; GO:0010496; GO:0006811; GO:2001258; GO:0032809; GO:0004860 calcium channel inhibitor activity; cell differentiation; determination of left/right asymmetry in nervous system; gap junction; gap junction hemi-channel activity; inactivation of MAPKKK activity; integral to membrane; intercellular transport; ion transport; negative regulation of cation channel activity; neuronal cell body membrane; protein kinase inhibitor activity IPR000990; Innexin-19 (Neuronal symmetry protein 5) (Protein opu-19) inx-19 nsy-5 opu-19 T16H5.1 Caenorhabditis elegans TR38729_c0_g1_i4 Q21123 INX7_CAEEL 7.00E-06 GO:0005921; GO:0055077; GO:0016021; GO:0006811; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transport; plasma membrane IPR000990; Innexin-7 (Protein opu-7) inx-7 opu-7 K02B2.4 Caenorhabditis elegans TR38729_c0_g1_i8 Q03412 UNC7_CAEEL 2.00E-10 GO:0005921; GO:0016264; GO:0055077; GO:0016021; GO:0034220; GO:0040011; GO:0032589; GO:0018991; GO:0043051; GO:0042221 gap junction; gap junction assembly; gap junction hemi-channel activity; integral to membrane; ion transmembrane transport; locomotion; neuron projection membrane; oviposition; regulation of pharyngeal pumping; response to chemical stimulus IPR000990; Innexin unc-7 (Uncoordinated protein 7) unc-7 unc-12 unc-124 R07D5.1 Caenorhabditis elegans TR3873_c0_g1_i1 Q9IAT6 DLLC_DANRE 7.00E-15 GO:0007219; GO:0030165; GO:0048514; GO:0005509; GO:0060218; GO:0042802; GO:0016021; GO:0048666; GO:0048471; GO:0005886; GO:0001757 Notch signaling pathway; PDZ domain binding; blood vessel morphogenesis; calcium ion binding; hematopoietic stem cell differentiation; identical protein binding; integral to membrane; neuron development; perinuclear region of cytoplasm; plasma membrane; somite specification IPR001774; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR011651; Delta-like protein C (DeltaC) (delC) dlc Danio rerio (Zebrafish) (Brachydanio rerio) TR38731_c0_g3_i2 O96006 ZBED1_HUMAN 4.00E-16 GO:0003677; GO:0046872; GO:0000228; GO:0004803 DNA binding; metal ion binding; nuclear chromosome; transposase activity IPR008906; IPR012337; IPR003656; Zinc finger BED domain-containing protein 1 (Putative Ac-like transposable element) (dREF homolog) ZBED1 ALTE DREF KIAA0785 TRAMP Homo sapiens (Human) TR38732_c3_g1_i1 Q9J516 V219_FOWPN 2.00E-09 GO:0004190; GO:0006508 aspartic-type endopeptidase activity; proteolysis IPR002110; IPR020683; IPR001995; IPR018272; Putative ankyrin repeat protein FPV219 FPV219 Fowlpox virus (strain NVSL) (FPV) TR38732_c3_g1_i2 Q68DC2 ANKS6_HUMAN 4.00E-11 GO:0005737 cytoplasm IPR002110; IPR020683; IPR001660; IPR013761; IPR021129; Ankyrin repeat and SAM domain-containing protein 6 (Ankyrin repeat domain-containing protein 14) (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6) ANKS6 ANKRD14 PKDR1 SAMD6 Homo sapiens (Human) TR38732_c3_g2_i1 Q7T163 KDIS_DANRE 2.00E-12 GO:0016021; GO:0005770; GO:0007399 integral to membrane; late endosome; nervous system development IPR002110; IPR020683; IPR011646; Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) kidins220 arms kidins220b si:dkeyp-7f8.3 si:dz119j18.2 zgc:63531 Danio rerio (Zebrafish) (Brachydanio rerio) TR38732_c3_g2_i2 Q5UPJ9 YL122_MIMIV 9.00E-12 IPR002110; IPR020683; Putative ankyrin repeat protein L122 MIMI_L122 Acanthamoeba polyphaga mimivirus (APMV) TR38733_c1_g2_i1 P09380 SSBPA_XENLA 1.00E-20 GO:0006260; GO:0003682; GO:0042645; GO:0003697 DNA replication; chromatin binding; mitochondrial nucleoid; single-stranded DNA binding IPR012340; IPR000424; IPR011344; "Single-stranded DNA-binding protein 1-A, mitochondrial (Single-stranded DNA-binding protein 1, mitochondrial) (MtSSB-1) (XlSSB1) (Single-stranded DNA-binding protein S, mitochondrial) (MtSSBs) (xl-mtssb)" ssbp1-a mtssb mtssb1 Xenopus laevis (African clawed frog) TR38733_c2_g1_i1 Q6DV14 PRDX1_GECJA 3.00E-89 GO:0005737; GO:0004601; GO:0051920 cytoplasm; peroxidase activity; peroxiredoxin activity IPR000866; IPR024706; IPR019479; IPR012336; Peroxiredoxin-1 (EC 1.11.1.15) PRDX1 GekBS014P Gecko japonicus (Japanese gecko) TR38733_c2_g1_i2 O08807 PRDX4_MOUSE 8.00E-116 GO:0005615; GO:0008584; GO:0005739; GO:2000255; GO:0055114; GO:0004601; GO:0051920; GO:0072593; GO:0007283 extracellular space; male gonad development; mitochondrion; negative regulation of male germ cell proliferation; oxidation-reduction process; peroxidase activity; peroxiredoxin activity; reactive oxygen species metabolic process; spermatogenesis IPR000866; IPR024706; IPR019479; IPR012336; Peroxiredoxin-4 (EC 1.11.1.15) (Antioxidant enzyme AOE372) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) Prdx4 Mus musculus (Mouse) TR38734_c0_g5_i1 Q8NHY2 RFWD2_HUMAN 9.00E-10 GO:0006977; GO:0005813; GO:0005829; GO:0005925; GO:0016874; GO:0016607; GO:0005654; GO:0016567; GO:0008270 Q7L5N1; P31947 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; centrosome; cytosol; focal adhesion; ligase activity; nuclear speck; nucleoplasm; protein ubiquitination; zinc ion binding" IPR015943; IPR001680; IPR019775; IPR017986; IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RFWD2 (EC 6.3.2.-) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) RFWD2 COP1 RNF200 Homo sapiens (Human) TR38734_c0_g5_i2 Q5TJF3 RING1_CANFA 4.00E-07 GO:0035102; GO:0009952; GO:0048593; GO:0003682; GO:0005737; GO:0035518; GO:0045892; GO:0016607; GO:0001739; GO:0006351; GO:0000151; GO:0004842; GO:0008270 "PRC1 complex; anterior/posterior pattern specification; camera-type eye morphogenesis; chromatin binding; cytoplasm; histone H2A monoubiquitination; negative regulation of transcription, DNA-dependent; nuclear speck; sex chromatin; transcription, DNA-dependent; ubiquitin ligase complex; ubiquitin-protein ligase activity; zinc ion binding" IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RING1 (EC 6.3.2.-) (Polycomb complex protein RING1) (RING finger protein 1) (RING1a) RING1 Canis familiaris (Dog) (Canis lupus familiaris) TR38735_c5_g1_i1 Q8IS15 GEFI_DICDI 4.00E-42 GO:0005085; GO:0005622; GO:0051056; GO:0007264 guanyl-nucleotide exchange factor activity; intracellular; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR006594; IPR000651; IPR008937; IPR023578; IPR001895; Ras guanine nucleotide exchange factor I (RasGEF domain-containing protein I) gefI rasGEFI DDB_G0277915 Dictyostelium discoideum (Slime mold) TR38735_c5_g1_i3 O77086 C3G_DROME 3.00E-128 GO:0005088; GO:0007265; GO:0005622; GO:0016203; GO:0032317; GO:0045214; GO:0007525 Ras guanyl-nucleotide exchange factor activity; Ras protein signal transduction; intracellular; muscle attachment; regulation of Rap GTPase activity; sarcomere organization; somatic muscle development IPR000651; IPR019804; IPR008937; IPR023578; IPR001895; Guanine nucleotide-releasing factor 2 (CRK SH3-binding GNRP) (DC3G) C3G CG42328 Drosophila melanogaster (Fruit fly) TR38735_c5_g1_i5 Q13905 RPGF1_HUMAN 2.00E-143 GO:0017034; GO:0032486; GO:0000186; GO:0001568; GO:0016337; GO:0071320; GO:0005829; GO:0005769; GO:0061028; GO:0038180; GO:0048011; GO:0048008; GO:0032854; GO:0010976; GO:1901888 P00519; P46108; P46109; P06241; P16333; P27986; P12931 Rap guanyl-nucleotide exchange factor activity; Rap protein signal transduction; activation of MAPKK activity; blood vessel development; cell-cell adhesion; cellular response to cAMP; cytosol; early endosome; establishment of endothelial barrier; nerve growth factor signaling pathway; neurotrophin TRK receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; positive regulation of Rap GTPase activity; positive regulation of neuron projection development; regulation of cell junction assembly IPR000651; IPR019804; IPR008937; IPR023578; IPR001895; Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) RAPGEF1 GRF2 Homo sapiens (Human) TR38735_c5_g1_i6 Q13905 RPGF1_HUMAN 1.00E-24 GO:0017034; GO:0032486; GO:0000186; GO:0001568; GO:0016337; GO:0071320; GO:0005829; GO:0005769; GO:0061028; GO:0038180; GO:0048011; GO:0048008; GO:0032854; GO:0010976; GO:1901888 P00519; P46108; P46109; P06241; P16333; P27986; P12931 Rap guanyl-nucleotide exchange factor activity; Rap protein signal transduction; activation of MAPKK activity; blood vessel development; cell-cell adhesion; cellular response to cAMP; cytosol; early endosome; establishment of endothelial barrier; nerve growth factor signaling pathway; neurotrophin TRK receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; positive regulation of Rap GTPase activity; positive regulation of neuron projection development; regulation of cell junction assembly IPR000651; IPR019804; IPR008937; IPR023578; IPR001895; Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) RAPGEF1 GRF2 Homo sapiens (Human) TR38736_c3_g1_i1 O14974 MYPT1_HUMAN 1.00E-09 GO:0071889; GO:0000086; GO:0072357; GO:0005813; GO:0051297; GO:0043292; GO:0004857; GO:0000776; GO:0007067; GO:0005654; GO:0019208; GO:0045944; GO:0006470; GO:0030155; GO:0035507; GO:0046822; GO:0004871 14-3-3 protein binding; G2/M transition of mitotic cell cycle; PTW/PP1 phosphatase complex; centrosome; centrosome organization; contractile fiber; enzyme inhibitor activity; kinetochore; mitosis; nucleoplasm; phosphatase regulator activity; positive regulation of transcription from RNA polymerase II promoter; protein dephosphorylation; regulation of cell adhesion; regulation of myosin-light-chain-phosphatase activity; regulation of nucleocytoplasmic transport; signal transducer activity IPR002110; IPR020683; IPR017401; Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) PPP1R12A MBS MYPT1 Homo sapiens (Human) TR38736_c3_g1_i2 Q9ULJ7 ANR50_HUMAN 2.00E-17 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) TR38736_c3_g1_i3 Q8N6D5 ANR29_HUMAN 7.00E-14 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 29 ANKRD29 Homo sapiens (Human) TR38736_c3_g1_i4 Q9J4Z8 V242_FOWPN 7.00E-07 IPR002110; IPR020683; Putative ankyrin repeat protein FPV242 FPV242 Fowlpox virus (strain NVSL) (FPV) TR38736_c3_g1_i5 A6QPE7 ANR65_BOVIN 1.00E-11 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 65 ANKRD65 Bos taurus (Bovine) TR38736_c3_g1_i6 P40480 HOS4_YEAST 2.00E-08 GO:0034967; GO:0016575; GO:0045835 P38262 Set3 complex; histone deacetylation; negative regulation of meiosis IPR002110; IPR020683; Protein HOS4 HOS4 YIL112W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR38737_c0_g3_i1 A7S1L6 FUCT1_NEMVE 3.00E-132 GO:0000139; GO:0008643; GO:0016021 Golgi membrane; carbohydrate transport; integral to membrane IPR000620; IPR004853; GDP-fucose transporter 1 (Solute carrier family 35 member C1 homolog) slc35c1 fuct1 v1g205399 Nematostella vectensis (Starlet sea anemone) TR38739_c0_g2_i1 Q5PQ44 CD022_XENLA 1.00E-116 IPR027887; Uncharacterized protein C4orf22 homolog Xenopus laevis (African clawed frog) TR38741_c0_g1_i1 Q6FQU5 DHH1_CANGA 7.00E-96 GO:0005524; GO:0008026; GO:0003723; GO:0000932; GO:0006397; GO:0051028; GO:0006417 ATP binding; ATP-dependent helicase activity; RNA binding; cytoplasmic mRNA processing body; mRNA processing; mRNA transport; regulation of translation IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DHH1 (EC 3.6.4.13) DHH1 CAGL0I03476g Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) TR38741_c0_g1_i2 Q0UAT0 FAL1_PHANO 0 GO:0005524; GO:0008026; GO:0003723; GO:0005730; GO:0006364 ATP binding; ATP-dependent helicase activity; RNA binding; nucleolus; rRNA processing IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase FAL1 (EC 3.6.4.13) FAL1 SNOG_11134 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum) TR38741_c0_g1_i3 Q11039 DEAD_MYCTU 3.00E-76 GO:0005524; GO:0008026; GO:0003723; GO:0005618; GO:0005829; GO:0006950 ATP binding; ATP-dependent helicase activity; RNA binding; cell wall; cytosol; response to stress IPR005580; IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DeaD (EC 3.6.4.13) (Cold-shock DEAD box protein A) deaD csdA Rv1253 MT1292 MTCY50.29c Mycobacterium tuberculosis TR38741_c0_g1_i4 Q3B8Q2 IF4A3_RAT 0 GO:0005524; GO:0004004; GO:0008380; GO:0071013; GO:0005737; GO:0035145; GO:0006397; GO:0051028; GO:0017148; GO:0016607; GO:0000184; GO:0008143; GO:0045727; GO:0006364; GO:0000381 "ATP binding; ATP-dependent RNA helicase activity; RNA splicing; catalytic step 2 spliceosome; cytoplasm; exon-exon junction complex; mRNA processing; mRNA transport; negative regulation of translation; nuclear speck; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; poly(A) RNA binding; positive regulation of translation; rRNA processing; regulation of alternative mRNA splicing, via spliceosome" IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; "Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic translation initiation factor 4A isoform 3) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]" Eif4a3 Ddx48 Rattus norvegicus (Rat) TR38741_c0_g2_i1 Q869P0 DDX31_DICDI 2.00E-11 GO:0005524; GO:0008026; GO:0003723 ATP binding; ATP-dependent helicase activity; RNA binding IPR011545; IPR025313; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase ddx31 (EC 3.6.4.13) (DEAD box protein 31) ddx31 DDB_G0271708 Dictyostelium discoideum (Slime mold) TR38741_c0_g3_i1 Q5ZM36 IF4A3_CHICK 3.00E-66 GO:0005524; GO:0004004; GO:0008380; GO:0071013; GO:0005737; GO:0035145; GO:0006397; GO:0051028; GO:0017148; GO:0016607; GO:0000184; GO:0008143; GO:0045727; GO:0000381 "ATP binding; ATP-dependent RNA helicase activity; RNA splicing; catalytic step 2 spliceosome; cytoplasm; exon-exon junction complex; mRNA processing; mRNA transport; negative regulation of translation; nuclear speck; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; poly(A) RNA binding; positive regulation of translation; regulation of alternative mRNA splicing, via spliceosome" IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic translation initiation factor 4A isoform 3) EIF4A3 DDX48 RCJMB04_3e17 Gallus gallus (Chicken) TR38742_c0_g1_i1 Q5ZJN2 RB11A_CHICK 3.00E-127 GO:0005525; GO:0006184; GO:0003924; GO:0032154; GO:0000910; GO:0032402; GO:0031175; GO:0045335; GO:0005886; GO:0043234; GO:0072659; GO:0015031; GO:0055038; GO:0007264; GO:0005802; GO:0016192 GTP binding; GTP catabolic process; GTPase activity; cleavage furrow; cytokinesis; melanosome transport; neuron projection development; phagocytic vesicle; plasma membrane; protein complex; protein localization to plasma membrane; protein transport; recycling endosome membrane; small GTPase mediated signal transduction; trans-Golgi network; vesicle-mediated transport IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-11A RAB11A RCJMB04_16p4 Gallus gallus (Chicken) TR38743_c1_g1_i1 P10394 POL4_DROME 1.00E-05 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR38743_c4_g1_i6 P10394 POL4_DROME 7.00E-19 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR38744_c2_g1_i1 B4ESA3 IVB2L_BUNMU 9.00E-16 GO:0005576; GO:0008191; GO:0004867 extracellular region; metalloendopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Protease inhibitor-like protein 2 (PILP-2) Bungarus multicinctus (Many-banded krait) TR38745_c1_g1_i1 O16076 HSP83_DROPE 1.00E-37 GO:0005524; GO:0005737; GO:0006457; GO:0006950 ATP binding; cytoplasm; protein folding; response to stress IPR003594; IPR019805; IPR001404; IPR020575; Heat shock protein 83 (HSP 82) (Fragment) Hsp83 Hsp82 Drosophila persimilis (Fruit fly) TR38745_c1_g2_i1 Q24VT7 HTPG_DESHY 2.00E-111 GO:0005524; GO:0005737; GO:0006457; GO:0006950 ATP binding; cytoplasm; protein folding; response to stress IPR003594; IPR019805; IPR001404; IPR020575; IPR020568; Chaperone protein HtpG (Heat shock protein HtpG) (High temperature protein G) htpG DSY2066 Desulfitobacterium hafniense (strain Y51) TR38745_c1_g2_i2 Q5XHZ0 TRAP1_RAT 0 GO:0005524; GO:0005743; GO:0005759; GO:1901856; GO:0006457; GO:0006950 ATP binding; mitochondrial inner membrane; mitochondrial matrix; negative regulation of cellular respiration; protein folding; response to stress IPR003594; IPR001404; IPR020575; IPR020568; "Heat shock protein 75 kDa, mitochondrial (HSP 75) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)" Trap1 Hsp75 Rattus norvegicus (Rat) TR38749_c2_g3_i5 Q6PGD0 ARAID_MOUSE 1.00E-32 GO:0030154; GO:0016021; GO:2000599; GO:0033689; GO:0005635; GO:0048471; GO:0005886; GO:0030501; GO:0045669; GO:0010468 cell differentiation; integral to membrane; negative regulation of cyclin catabolic process; negative regulation of osteoblast proliferation; nuclear envelope; perinuclear region of cytoplasm; plasma membrane; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; regulation of gene expression IPR000742; IPR013032; All-trans retinoic acid-induced differentiation factor (Apoptosis-related protein 3) (APR-3) Atraid Apr3 Mus musculus (Mouse) TR38751_c0_g1_i1 P05183 CP3A2_RAT 4.00E-36 GO:0070330; GO:0032451; GO:0017144; GO:0005789; GO:0020037; GO:0005506; GO:0070989; GO:0050649 aromatase activity; demethylase activity; drug metabolic process; endoplasmic reticulum membrane; heme binding; iron ion binding; oxidative demethylation; testosterone 6-beta-hydroxylase activity IPR001128; IPR017972; IPR008072; IPR002402; Cytochrome P450 3A2 (EC 1.14.14.1) (CYPIIIA2) (Cytochrome P450-PCN2) (Cytochrome P450/6-beta-A) (Testosterone 6-beta-hydroxylase) Cyp3a2 Cyp3a-2 Cyp3a11 Rattus norvegicus (Rat) TR38751_c0_g1_i4 Q09660 CC44_CAEEL 4.00E-120 GO:0020037; GO:0005506; GO:0004497; GO:0016705 "heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Probable cytochrome P450 CYP44 (EC 1.14.-.-) cyp-44A1 ccp-44 cyp44 ZK177.5 Caenorhabditis elegans TR38752_c0_g1_i1 P27136 TFDE1_CUPPJ 5.00E-11 GO:0019439; GO:0004091; GO:0008806 aromatic compound catabolic process; carboxylesterase activity; carboxymethylenebutenolidase activity IPR002925; Aromatic compound metabolism; 3-chlorocatechol degradation. Carboxymethylenebutenolidase 1 (EC 3.1.1.45) (Carboxymethylenebutenolidase I) (Dienelactone hydrolase I) (DLH I) tfdEI tfdE Reut_D6464 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134)) TR38752_c0_g1_i2 P46209 USF_AQUPY 1.00E-19 GO:0016787 hydrolase activity IPR002925; Protein usf usf Aquifex pyrophilus TR38752_c0_g1_i7 P0A115 CLCD_PSESB 2.00E-13 GO:0019439; GO:0004091; GO:0008806 aromatic compound catabolic process; carboxylesterase activity; carboxymethylenebutenolidase activity IPR002925; Aromatic compound metabolism; 3-chlorocatechol degradation. Carboxymethylenebutenolidase (EC 3.1.1.45) (Dienelactone hydrolase) (DLH) clcD Pseudomonas sp. (strain B13) TR38752_c0_g1_i8 Q7DFU6 YGHX_ECOLI 2.00E-24 GO:0016787 hydrolase activity IPR002925; Putative uncharacterized protein YghX yghX yghY b4658 JW5926/JW5496 b2999 b3000 Escherichia coli (strain K12) TR38753_c2_g5_i1 Q9Y2H8 ZN510_HUMAN 6.00E-23 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 510 ZNF510 KIAA0972 Homo sapiens (Human) TR38753_c3_g3_i1 Q8NCJ5 SPRY3_HUMAN 8.00E-136 IPR001870; IPR008985; IPR018355; IPR003877; SPRY domain-containing protein 3 SPRYD3 Homo sapiens (Human) TR38753_c3_g3_i2 A1L252 RANB9_DANRE 6.00E-21 GO:0005737; GO:0005634 cytoplasm; nucleus IPR001870; IPR008985; IPR013144; IPR024964; IPR006595; IPR006594; IPR013720; IPR027713; IPR018355; IPR003877; Ran-binding protein 9 (RanBP9) ranbp9 zgc:158650 Danio rerio (Zebrafish) (Brachydanio rerio) TR38753_c3_g3_i3 O94712 YC5C_SCHPO 4.00E-15 GO:0034657; GO:0045721; GO:0005634; GO:0043161; GO:0007165; GO:0007039 GID complex; negative regulation of gluconeogenesis; nucleus; proteasomal ubiquitin-dependent protein catabolic process; signal transduction; vacuolar protein catabolic process IPR001870; IPR008985; IPR013144; IPR024964; IPR006595; IPR006594; IPR013720; IPR027713; IPR018355; IPR003877; Uncharacterized protein C1259.12c SPCC1259.12c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38756_c1_g1_i1 A4IFB4 KCTD7_BOVIN 2.00E-14 GO:0005829; GO:0005886; GO:0051260 cytosol; plasma membrane; protein homooligomerization IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein KCTD7 KCTD7 Bos taurus (Bovine) TR38756_c1_g2_i2 Q9H3F6 BACD3_HUMAN 4.00E-113 GO:0031463; GO:0005737; GO:0005634; GO:0043161; GO:0051260; GO:0016567 Cul3-RING ubiquitin ligase complex; cytoplasm; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein homooligomerization; protein ubiquitination IPR000210; IPR011333; IPR003131; Protein modification; protein ubiquitination. BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (hBACURD3) (BTB/POZ domain-containing protein KCTD10) (Potassium channel tetramerization domain-containing protein 10) KCTD10 ULR061 MSTP028 Homo sapiens (Human) TR38757_c0_g1_i2 Q4LE85 RB27A_PIG 3.00E-14 GO:0019003; GO:0005525; GO:0003924; GO:0005794; GO:0007596; GO:0043316; GO:0030425; GO:0070382; GO:0005764; GO:0030318; GO:0042470; GO:0032402; GO:0032585; GO:0071985; GO:0043320; GO:0001750; GO:0045921; GO:0006605; GO:0030141; GO:0007264 GDP binding; GTP binding; GTPase activity; Golgi apparatus; blood coagulation; cytotoxic T cell degranulation; dendrite; exocytic vesicle; lysosome; melanocyte differentiation; melanosome; melanosome transport; multivesicular body membrane; multivesicular body sorting pathway; natural killer cell degranulation; photoreceptor outer segment; positive regulation of exocytosis; protein targeting; secretory granule; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-27A RAB27A Sus scrofa (Pig) TR38757_c0_g1_i3 Q7L0Q8 RHOU_HUMAN 2.00E-92 GO:0000082; GO:0005525; GO:0003924; GO:0000139; GO:0016601; GO:0030036; GO:0042995; GO:0007010; GO:0005829; GO:0005925; GO:0046872; GO:0005886; GO:0002102; GO:0008360; GO:0051056; GO:0007264 O43639; Q13153-2; Q14289 G1/S transition of mitotic cell cycle; GTP binding; GTPase activity; Golgi membrane; Rac protein signal transduction; actin cytoskeleton organization; cell projection; cytoskeleton organization; cytosol; focal adhesion; metal ion binding; plasma membrane; podosome; regulation of cell shape; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1) RHOU ARHU CDC42L1 G28K WRCH1 SB128 Homo sapiens (Human) TR38758_c6_g2_i13 Q8FTH8 THIED_COREF 1.00E-06 GO:0005524; GO:0008902; GO:0046872; GO:0008972; GO:0009228; GO:0009229; GO:0004789 ATP binding; hydroxymethylpyrimidine kinase activity; metal ion binding; phosphomethylpyrimidine kinase activity; thiamine biosynthetic process; thiamine diphosphate biosynthetic process; thiamine-phosphate diphosphorylase activity IPR013785; IPR016084; IPR013749; IPR004399; IPR004305; IPR022998; IPR003733; Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3. Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1. Thiamine biosynthesis multifunctional protein ThiED [Includes: Thiamine-phosphate synthase (TMP-PPase) (TP synthase) (TPS) (EC 2.5.1.3) (Thiamine-phosphate pyrophosphorylase) (TMP pyrophosphorylase); Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (EC 2.7.1.49) (EC 2.7.4.7) (Hydroxymethylpyrimidine kinase) (HMP kinase) (Hydroxymethylpyrimidine phosphate kinase) (HMP-P kinase) (HMP-phosphate kinase) (HMPP kinase)] thiED CE1591 Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) TR38758_c6_g2_i9 Q8FTH8 THIED_COREF 1.00E-06 GO:0005524; GO:0008902; GO:0046872; GO:0008972; GO:0009228; GO:0009229; GO:0004789 ATP binding; hydroxymethylpyrimidine kinase activity; metal ion binding; phosphomethylpyrimidine kinase activity; thiamine biosynthetic process; thiamine diphosphate biosynthetic process; thiamine-phosphate diphosphorylase activity IPR013785; IPR016084; IPR013749; IPR004399; IPR004305; IPR022998; IPR003733; Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3. Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1. Thiamine biosynthesis multifunctional protein ThiED [Includes: Thiamine-phosphate synthase (TMP-PPase) (TP synthase) (TPS) (EC 2.5.1.3) (Thiamine-phosphate pyrophosphorylase) (TMP pyrophosphorylase); Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (EC 2.7.1.49) (EC 2.7.4.7) (Hydroxymethylpyrimidine kinase) (HMP kinase) (Hydroxymethylpyrimidine phosphate kinase) (HMP-P kinase) (HMP-phosphate kinase) (HMPP kinase)] thiED CE1591 Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) TR38759_c4_g1_i1 P0AC33 FUMA_ECOLI 0 GO:0051539; GO:0005829; GO:0004333; GO:0046872; GO:0050163; GO:0006099 "4 iron, 4 sulfur cluster binding; cytosol; fumarate hydratase activity; metal ion binding; oxaloacetate tautomerase activity; tricarboxylic acid cycle" IPR004646; IPR004647; IPR011167; IPR020557; Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1. "Fumarate hydratase class I, aerobic (Fumarase) (EC 4.2.1.2)" fumA b1612 JW1604 Escherichia coli (strain K12) TR38759_c4_g1_i2 P0AC33 FUMA_ECOLI 0 GO:0051539; GO:0005829; GO:0004333; GO:0046872; GO:0050163; GO:0006099 "4 iron, 4 sulfur cluster binding; cytosol; fumarate hydratase activity; metal ion binding; oxaloacetate tautomerase activity; tricarboxylic acid cycle" IPR004646; IPR004647; IPR011167; IPR020557; Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1. "Fumarate hydratase class I, aerobic (Fumarase) (EC 4.2.1.2)" fumA b1612 JW1604 Escherichia coli (strain K12) TR38761_c0_g2_i2 P58743 S26A5_HUMAN 1.00E-124 GO:0016323; GO:0016021; GO:0016328; GO:0008360; GO:0042391; GO:0008271; GO:0007605; GO:0008272 basolateral plasma membrane; integral to membrane; lateral plasma membrane; regulation of cell shape; regulation of membrane potential; secondary active sulfate transmembrane transporter activity; sensory perception of sound; sulfate transport IPR018045; IPR002645; IPR001902; IPR011547; Prestin (Solute carrier family 26 member 5) SLC26A5 PRES Homo sapiens (Human) TR38762_c0_g2_i2 Q7YQK9 TSN7_PONPY 1.00E-07 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-7 (Tspan-7) (Transmembrane 4 superfamily member 2) (CD antigen CD231) TSPAN7 TM4SF2 Pongo pygmaeus (Bornean orangutan) TR38762_c0_g2_i4 Q3ZBH3 CD151_BOVIN 2.00E-06 GO:0016021 integral to membrane IPR000301; IPR018499; IPR008952; CD151 antigen (CD antigen CD151) CD151 Bos taurus (Bovine) TR38764_c2_g1_i2 Q5RFN6 CNN2_PONAB 2.00E-10 GO:0031032; GO:0071260; GO:0030097; GO:0030336; GO:0050765; GO:0010628; GO:0032970; GO:0042127; GO:0001725; GO:0042060 actomyosin structure organization; cellular response to mechanical stimulus; hemopoiesis; negative regulation of cell migration; negative regulation of phagocytosis; positive regulation of gene expression; regulation of actin filament-based process; regulation of cell proliferation; stress fiber; wound healing IPR001997; IPR000557; IPR001715; IPR003096; "Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin)" CNN2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38764_c2_g2_i1 Q7YRL2 CNN1_SHEEP 3.00E-12 GO:0031032 actomyosin structure organization IPR001997; IPR000557; IPR001715; IPR003096; "Calponin-1 (Basic calponin) (Calponin H1, smooth muscle)" CNN1 Ovis aries (Sheep) TR38765_c0_g1_i1 Q9UL16 CCD19_HUMAN 2.00E-50 GO:0005739; GO:0005634 mitochondrion; nucleus "Coiled-coil domain-containing protein 19, mitochondrial (Nasopharyngeal epithelium-specific protein 1)" CCDC19 NESG1 Homo sapiens (Human) TR38765_c0_g2_i2 Q9UL16 CCD19_HUMAN 3.00E-40 GO:0005739; GO:0005634 mitochondrion; nucleus "Coiled-coil domain-containing protein 19, mitochondrial (Nasopharyngeal epithelium-specific protein 1)" CCDC19 NESG1 Homo sapiens (Human) TR38766_c1_g1_i1 Q8STF0 CALM_STRIE 4.00E-48 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Strongylocentrotus intermedius (Sea urchin) TR38766_c1_g1_i2 Q06827 CATR_SCHDU 5.00E-26 GO:0005524; GO:0008026; GO:0005509; GO:0051301; GO:0007067; GO:0003676 ATP binding; ATP-dependent helicase activity; calcium ion binding; cell division; mitosis; nucleic acid binding IPR011992; IPR018247; IPR002048; IPR000629; Caltractin (Centrin) Scherffelia dubia (Green alga) (Chlamydomonas dubia) TR38766_c1_g1_i3 O94739 CALM_PLEOS 7.00E-51 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) CMD1 Pleurotus ostreatus (Oyster mushroom) (White-rot fungus) TR38766_c1_g1_i4 P54680 FIMB_DICDI 3.00E-10 GO:0051015; GO:0051017; GO:0005509; GO:0030027; GO:0001891; GO:0045335; GO:0019953 actin filament binding; actin filament bundle assembly; calcium ion binding; lamellipodium; phagocytic cup; phagocytic vesicle; sexual reproduction IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; Fimbrin fimA DDB_G0277855 Dictyostelium discoideum (Slime mold) TR38768_c0_g3_i3 Q8BQC3 IGDC3_MOUSE 2.00E-10 GO:0005887; GO:0050885 integral to plasma membrane; neuromuscular process controlling balance IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; Immunoglobulin superfamily DCC subclass member 3 (Putative neuronal cell adhesion molecule) Igdcc3 Punc Mus musculus (Mouse) TR38769_c0_g2_i3 Q9HAV4 XPO5_HUMAN 1.00E-39 GO:0003723; GO:0005829; GO:0010467; GO:0031047; GO:0005654; GO:0006611; GO:0008565; GO:0000049 RNA binding; cytosol; gene expression; gene silencing by RNA; nucleoplasm; protein export from nucleus; protein transporter activity; tRNA binding IPR011989; IPR016024; IPR013598; IPR001494; Exportin-5 (Exp5) (Ran-binding protein 21) XPO5 KIAA1291 RANBP21 Homo sapiens (Human) TR38770_c0_g2_i1 Q95YM9 FGFR_HALRO 1.00E-27 GO:0005524; GO:0048701; GO:0005007; GO:0016021; GO:0018108; GO:0008284 ATP binding; embryonic cranial skeleton morphogenesis; fibroblast growth factor-activated receptor activity; integral to membrane; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation IPR028175; IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor (HrFGFR) (EC 2.7.10.1) FGFR Halocynthia roretzi (Sea squirt) TR38770_c0_g2_i3 P11799 MYLK_CHICK 5.00E-10 GO:0005524; GO:0005829; GO:0016020; GO:0046872; GO:0004687 ATP binding; cytosol; membrane; metal ion binding; myosin light chain kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR020675; IPR000719; IPR017441; IPR002290; IPR008271; "Myosin light chain kinase, smooth muscle (MLCK) (EC 2.7.11.18) (Telokin)" Gallus gallus (Chicken) TR38770_c0_g2_i4 Q2EY13 PRTGB_DANRE 1.00E-06 GO:0016021; GO:0007275 integral to membrane; multicellular organismal development IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; Protogenin B (Fragment) prtgb Danio rerio (Zebrafish) (Brachydanio rerio) TR38770_c0_g2_i5 Q95YM9 FGFR_HALRO 1.00E-27 GO:0005524; GO:0048701; GO:0005007; GO:0016021; GO:0018108; GO:0008284 ATP binding; embryonic cranial skeleton morphogenesis; fibroblast growth factor-activated receptor activity; integral to membrane; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation IPR028175; IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor (HrFGFR) (EC 2.7.10.1) FGFR Halocynthia roretzi (Sea squirt) TR38770_c0_g2_i6 P18461 FGFR2_CHICK 2.00E-24 GO:0005524; GO:0005794; GO:0006915; GO:0016023; GO:0048701; GO:0005007; GO:0016021; GO:0018108; GO:0005886; GO:0008284 ATP binding; Golgi apparatus; apoptotic process; cytoplasmic membrane-bounded vesicle; embryonic cranial skeleton morphogenesis; fibroblast growth factor-activated receptor activity; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; positive regulation of cell proliferation IPR028175; IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (Tyrosine kinase receptor CEK3) FGFR2 CEK3 Gallus gallus (Chicken) TR38770_c0_g2_i7 O01761 UNC89_CAEEL 8.00E-12 GO:0005524; GO:0031430; GO:0005089; GO:0005543; GO:0004672; GO:0035023; GO:0030241 ATP binding; M band; Rho guanyl-nucleotide exchange factor activity; phospholipid binding; protein kinase activity; regulation of Rho protein signal transduction; skeletal muscle myosin thick filament assembly IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR007850; IPR001452; Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans TR38771_c2_g3_i1 O95237 LRAT_HUMAN 1.00E-12 GO:0009790; GO:0005789; GO:0016021; GO:0005771; GO:0048471; GO:0047173; GO:0007603; GO:0001972; GO:0042573; GO:0001523; GO:0019841; GO:0042572; GO:0005791; GO:0016746; GO:0007601; GO:0006776 "embryo development; endoplasmic reticulum membrane; integral to membrane; multivesicular body; perinuclear region of cytoplasm; phosphatidylcholine-retinol O-acyltransferase activity; phototransduction, visible light; retinoic acid binding; retinoic acid metabolic process; retinoid metabolic process; retinol binding; retinol metabolic process; rough endoplasmic reticulum; transferase activity, transferring acyl groups; visual perception; vitamin A metabolic process" IPR007053; Cofactor metabolism; retinol metabolism. Lecithin retinol acyltransferase (EC 2.3.1.135) (Phosphatidylcholine--retinol O-acyltransferase) LRAT Homo sapiens (Human) TR38772_c5_g2_i2 Q9I931 FUCL1_ANGJA 4.00E-10 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-1 Anguilla japonica (Japanese eel) TR38773_c0_g1_i1 P57788 MOT4_CHICK 8.00E-28 GO:0015629; GO:0016021; GO:0031965; GO:0005886; GO:0015355; GO:0015293 actin cytoskeleton; integral to membrane; nuclear membrane; plasma membrane; secondary active monocarboxylate transmembrane transporter activity; symporter activity IPR011701; IPR020846; IPR016196; IPR004743; Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3) SLC16A3 MCT4 Gallus gallus (Chicken) TR38773_c0_g1_i2 Q90632 MOT3_CHICK 5.00E-31 GO:0016021; GO:0005886; GO:0015355; GO:0015293 integral to membrane; plasma membrane; secondary active monocarboxylate transmembrane transporter activity; symporter activity IPR011701; IPR020846; IPR016196; IPR004743; Monocarboxylate transporter 3 (MCT 3) (Retinal epithelial membrane protein) (Solute carrier family 16 member 8) SLC16A3 MCT3 REMP Gallus gallus (Chicken) TR38773_c0_g1_i5 Q7RTX9 MOT14_HUMAN 2.00E-32 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR38774_c0_g1_i1 A7SCH8 KYNU_NEMVE 2.00E-169 GO:0097053; GO:0009435; GO:0005737; GO:0030429; GO:0030170; GO:0006569 L-kynurenine catabolic process; NAD biosynthetic process; cytoplasm; kynureninase activity; pyridoxal phosphate binding; tryptophan catabolic process IPR000192; IPR010111; IPR015424; IPR015421; IPR015422; Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase) kynu v1g235255 Nematostella vectensis (Starlet sea anemone) TR38774_c0_g1_i2 P70712 KYNU_RAT 7.00E-167 GO:0097053; GO:0009435; GO:0043420; GO:0005829; GO:0030429; GO:0005739; GO:0005634; GO:0030170; GO:0019805; GO:0034341; GO:0034516; GO:0019442; GO:0019441 L-kynurenine catabolic process; NAD biosynthetic process; anthranilate metabolic process; cytosol; kynureninase activity; mitochondrion; nucleus; pyridoxal phosphate binding; quinolinate biosynthetic process; response to interferon-gamma; response to vitamin B6; tryptophan catabolic process to acetyl-CoA; tryptophan catabolic process to kynurenine IPR000192; IPR010111; IPR015424; IPR015421; IPR015422; Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase) Kynu Rattus norvegicus (Rat) TR38777_c1_g2_i4 P0A961 ALAA_SHIFL 2.00E-26 GO:0030632; GO:0004021; GO:0005737; GO:0030170 D-alanine biosynthetic process; L-alanine:2-oxoglutarate aminotransferase activity; cytoplasm; pyridoxal phosphate binding IPR004839; IPR015424; IPR015421; IPR015422; Glutamate-pyruvate aminotransferase AlaA (EC 2.6.1.2) alaA yfbQ SF2366 S2501 Shigella flexneri TR38777_c1_g2_i5 Q8TD30 ALAT2_HUMAN 0 GO:0006103; GO:0042853; GO:0042851; GO:0004021; GO:0008652; GO:0034641; GO:0005759; GO:0030170 2-oxoglutarate metabolic process; L-alanine catabolic process; L-alanine metabolic process; L-alanine:2-oxoglutarate aminotransferase activity; cellular amino acid biosynthetic process; cellular nitrogen compound metabolic process; mitochondrial matrix; pyridoxal phosphate binding IPR004839; IPR015424; IPR015421; IPR015422; Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1. Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2) GPT2 AAT2 ALT2 Homo sapiens (Human) TR38778_c0_g1_i2 Q92556 ELMO1_HUMAN 0 GO:0038096; GO:0016601; GO:0030036; GO:0006915; GO:0006928; GO:0005856; GO:0005829; GO:0045087; GO:0006911; GO:0005543; GO:0005886; GO:0050690; GO:0016032 Q14185; P08631; P84095 "Fc-gamma receptor signaling pathway involved in phagocytosis; Rac protein signal transduction; actin cytoskeleton organization; apoptotic process; cellular component movement; cytoskeleton; cytosol; innate immune response; phagocytosis, engulfment; phospholipid binding; plasma membrane; regulation of defense response to virus by virus; viral process" IPR011989; IPR016024; IPR024574; IPR006816; IPR011993; IPR001849; Engulfment and cell motility protein 1 (Protein ced-12 homolog) ELMO1 KIAA0281 Homo sapiens (Human) TR38778_c0_g1_i3 Q96BJ8 ELMO3_HUMAN 4.00E-170 GO:0006915; GO:0005737; GO:0005856; GO:0006909; GO:0005543 apoptotic process; cytoplasm; cytoskeleton; phagocytosis; phospholipid binding IPR016024; IPR024574; IPR006816; IPR011993; IPR001849; Engulfment and cell motility protein 3 ELMO3 Homo sapiens (Human) TR38778_c0_g1_i4 Q92556 ELMO1_HUMAN 0 GO:0038096; GO:0016601; GO:0030036; GO:0006915; GO:0006928; GO:0005856; GO:0005829; GO:0045087; GO:0006911; GO:0005543; GO:0005886; GO:0050690; GO:0016032 Q14185; P08631; P84095 "Fc-gamma receptor signaling pathway involved in phagocytosis; Rac protein signal transduction; actin cytoskeleton organization; apoptotic process; cellular component movement; cytoskeleton; cytosol; innate immune response; phagocytosis, engulfment; phospholipid binding; plasma membrane; regulation of defense response to virus by virus; viral process" IPR011989; IPR016024; IPR024574; IPR006816; IPR011993; IPR001849; Engulfment and cell motility protein 1 (Protein ced-12 homolog) ELMO1 KIAA0281 Homo sapiens (Human) TR38778_c0_g1_i7 Q54YW1 ELMOA_DICDI 1.00E-15 GO:0048870; GO:0005737; GO:0005856; GO:0030837; GO:0006909; GO:0050764; GO:0030587 P08799 cell motility; cytoplasm; cytoskeleton; negative regulation of actin filament polymerization; phagocytosis; regulation of phagocytosis; sorocarp development IPR016024; IPR006816; ELMO domain-containing protein A elmoA DDB_G0278051 Dictyostelium discoideum (Slime mold) TR38778_c0_g1_i8 Q92556 ELMO1_HUMAN 0 GO:0038096; GO:0016601; GO:0030036; GO:0006915; GO:0006928; GO:0005856; GO:0005829; GO:0045087; GO:0006911; GO:0005543; GO:0005886; GO:0050690; GO:0016032 Q14185; P08631; P84095 "Fc-gamma receptor signaling pathway involved in phagocytosis; Rac protein signal transduction; actin cytoskeleton organization; apoptotic process; cellular component movement; cytoskeleton; cytosol; innate immune response; phagocytosis, engulfment; phospholipid binding; plasma membrane; regulation of defense response to virus by virus; viral process" IPR011989; IPR016024; IPR024574; IPR006816; IPR011993; IPR001849; Engulfment and cell motility protein 1 (Protein ced-12 homolog) ELMO1 KIAA0281 Homo sapiens (Human) TR38780_c0_g1_i1 Q13772 NCOA4_HUMAN 2.00E-16 GO:0050681; GO:0030521; GO:0008584; GO:0005634; GO:0045893; GO:0009725; GO:0003713; GO:0006351 "androgen receptor binding; androgen receptor signaling pathway; male gonad development; nucleus; positive regulation of transcription, DNA-dependent; response to hormone stimulus; transcription coactivator activity; transcription, DNA-dependent" IPR022174; Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ret-activating protein ELE1) NCOA4 ARA70 ELE1 RFG Homo sapiens (Human) TR38781_c3_g1_i2 Q91VS8 FARP2_MOUSE 4.00E-09 GO:0030676; GO:0016601; GO:0031532; GO:0007155; GO:0005856; GO:0005829; GO:0019898; GO:0016322; GO:0030316; GO:0005543; GO:0071800; GO:0035023; GO:0033623; GO:0071526 Rac guanyl-nucleotide exchange factor activity; Rac protein signal transduction; actin cytoskeleton reorganization; cell adhesion; cytoskeleton; cytosol; extrinsic to membrane; neuron remodeling; osteoclast differentiation; phospholipid binding; podosome assembly; regulation of Rho protein signal transduction; regulation of integrin activation; semaphorin-plexin signaling pathway IPR019749; IPR019750; IPR000219; IPR000798; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; IPR001849; "FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR)" Farp2 Kiaa0793 Mus musculus (Mouse) TR38781_c3_g1_i7 P52734 FGD1_MOUSE 9.00E-18 GO:0005794; GO:0005089; GO:0030036; GO:0005856; GO:0007010; GO:0046847; GO:0030027; GO:0046872; GO:0005634; GO:0005543; GO:0005886; GO:0043088; GO:0008360; GO:0001726 Golgi apparatus; Rho guanyl-nucleotide exchange factor activity; actin cytoskeleton organization; cytoskeleton; cytoskeleton organization; filopodium assembly; lamellipodium; metal ion binding; nucleus; phospholipid binding; plasma membrane; regulation of Cdc42 GTPase activity; regulation of cell shape; ruffle IPR000219; IPR011993; IPR001849; IPR000306; IPR017455; IPR013083; "FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3)" Fgd1 Mus musculus (Mouse) TR38782_c0_g2_i1 Q6BU95 ESA1_DEBHA 1.00E-86 GO:0016573; GO:0004402; GO:0005634; GO:0006355; GO:0006351 "histone acetylation; histone acetyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR016181; IPR000953; IPR016197; IPR002717; IPR025995; Histone acetyltransferase ESA1 (EC 2.3.1.48) ESA1 DEHA2C12628g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR38782_c0_g2_i2 Q9H7Z6 KAT8_HUMAN 0 GO:0071339; GO:0072487; GO:0043984; GO:0043981; GO:0043982; GO:0004402; GO:0000776; GO:0046872; GO:0035064; GO:0030099; GO:0045892; GO:0045893; GO:0008134; GO:0006351 P02309; Q03164; Q99496; P04637 "MLL1 complex; MSL complex; histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase activity; kinetochore; metal ion binding; methylated histone residue binding; myeloid cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; transcription factor binding; transcription, DNA-dependent" IPR016181; IPR000953; IPR016197; IPR002717; IPR025995; "Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (hMOF)" KAT8 MOF MYST1 PP7073 Homo sapiens (Human) TR38782_c0_g2_i3 Q6C710 ESA1_YARLI 5.00E-101 GO:0016573; GO:0004402; GO:0005634; GO:0006355; GO:0006351 "histone acetylation; histone acetyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR016181; IPR000953; IPR016197; IPR002717; IPR025995; Histone acetyltransferase ESA1 (EC 2.3.1.48) ESA1 YALI0E04675g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR38782_c0_g2_i4 Q9LXD7 MYST2_ARATH 2.00E-136 GO:0006281; GO:0004402; GO:0046872; GO:0005634; GO:0006355; GO:0010224; GO:0006351 "DNA repair; histone acetyltransferase activity; metal ion binding; nucleus; regulation of transcription, DNA-dependent; response to UV-B; transcription, DNA-dependent" IPR016181; IPR000953; IPR016197; IPR002717; IPR025995; IPR015880; MYST-like histone acetyltransferase 2 (EC 2.3.1.48) HAG5 At5g09740 F17I14.70 Arabidopsis thaliana (Mouse-ear cress) TR38782_c0_g2_i6 O02193 MOF_DROME 2.00E-156 GO:0044545; GO:0016456; GO:0003682; GO:0009047; GO:0046972; GO:0004468; GO:0003729; GO:0046872; GO:0005705; GO:0006355; GO:0005667 "NSL complex; X chromosome located dosage compensation complex, transcription activating; chromatin binding; dosage compensation by hyperactivation of X chromosome; histone acetyltransferase activity (H4-K16 specific); lysine N-acetyltransferase activity; mRNA binding; metal ion binding; polytene chromosome interband; regulation of transcription, DNA-dependent; transcription factor complex" IPR016181; IPR000953; IPR016197; IPR002717; IPR025995; Males-absent on the first protein (EC 2.3.1.-) (Histone acetyl transferase MOF) mof CG3025 Drosophila melanogaster (Fruit fly) TR38783_c4_g1_i1 P56276 MYLK_MELGA 1.00E-14 IPR007110; IPR013783; IPR013098; IPR003598; IPR020675; Telokin Meleagris gallopavo (Common turkey) TR38783_c4_g1_i2 Q9JIF9 MYOTI_MOUSE 3.00E-08 GO:0030018; GO:0051393; GO:0005856; GO:0042383 Z disc; alpha-actinin binding; cytoskeleton; sarcolemma IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Myotilin (Myofibrillar titin-like Ig domains protein) (Titin immunoglobulin domain protein) Myot Myo Ttid Mus musculus (Mouse) TR38783_c4_g1_i4 O02827 MYLK_SHEEP 8.00E-90 GO:0005524; GO:0032154; GO:0005737; GO:0005856; GO:0030027; GO:0046872; GO:0004687 ATP binding; cleavage furrow; cytoplasm; cytoskeleton; lamellipodium; metal ion binding; myosin light chain kinase activity IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR020675; IPR000719; IPR002290; IPR008271; "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] (Fragment)" MYLK Ovis aries (Sheep) TR38784_c0_g2_i2 A2ARI4 LGR4_MOUSE 2.00E-06 GO:0007186; GO:0030282; GO:0046849; GO:0061290; GO:0072202; GO:0050673; GO:0045087; GO:0005887; GO:0030539; GO:0072224; GO:0072282; GO:0050710; GO:0034122; GO:0045892; GO:0001649; GO:0090190; GO:0090263; GO:0045893; GO:0007283; GO:0004888 "G-protein coupled receptor signaling pathway; bone mineralization; bone remodeling; canonical Wnt receptor signaling pathway involved in metanephric kidney development; cell differentiation involved in metanephros development; epithelial cell proliferation; innate immune response; integral to plasma membrane; male genitalia development; metanephric glomerulus development; metanephric nephron tubule morphogenesis; negative regulation of cytokine secretion; negative regulation of toll-like receptor signaling pathway; negative regulation of transcription, DNA-dependent; osteoblast differentiation; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of transcription, DNA-dependent; spermatogenesis; transmembrane signaling receptor activity" IPR000276; IPR017452; IPR002131; IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48) Lgr4 Gpr48 Mus musculus (Mouse) TR38786_c0_g2_i2 Q3Y4E2 SELN_DANRE 2.00E-78 GO:0016021; GO:0048741 integral to membrane; skeletal muscle fiber development Selenoprotein N (SePN) (SelN) sepn1 sepn Danio rerio (Zebrafish) (Brachydanio rerio) TR38787_c0_g1_i1 Q96PH1 NOX5_HUMAN 2.00E-127 GO:0050661; GO:0001525; GO:0006915; GO:0005509; GO:0050663; GO:0000910; GO:0005783; GO:0001935; GO:0050660; GO:0020037; GO:0015252; GO:0016021; GO:2000379; GO:0043012; GO:0010155; GO:0042554; GO:0016175 P62157 NADP binding; angiogenesis; apoptotic process; calcium ion binding; cytokine secretion; cytokinesis; endoplasmic reticulum; endothelial cell proliferation; flavin adenine dinucleotide binding; heme binding; hydrogen ion channel activity; integral to membrane; positive regulation of reactive oxygen species metabolic process; regulation of fusion of sperm to egg plasma membrane; regulation of proton transport; superoxide anion generation; superoxide-generating NADPH oxidase activity IPR011992; IPR018247; IPR002048; IPR013112; IPR017927; IPR013130; IPR013121; IPR017938; NADPH oxidase 5 (EC 1.6.3.-) NOX5 Homo sapiens (Human) TR38787_c0_g1_i2 B3DLU1 NCALD_XENTR 3.00E-12 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Neurocalcin-delta ncald Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38787_c0_g1_i3 P46065 GUC1A_BOVIN 1.00E-14 GO:0005509; GO:0008048; GO:0016020; GO:0007602; GO:0007601 P55203; P81948 calcium ion binding; calcium sensitive guanylate cyclase activator activity; membrane; phototransduction; visual perception IPR011992; IPR018247; IPR002048; IPR001125; Guanylyl cyclase-activating protein 1 (GCAP 1) (Guanylate cyclase activator 1A) GUCA1A GCAP1 GUCA1 Bos taurus (Bovine) TR38788_c0_g2_i1 O54926 SIVA_MOUSE 5.00E-11 GO:0006915; GO:0005737; GO:0046872; GO:0005634; GO:0001618 apoptotic process; cytoplasm; metal ion binding; nucleus; virus receptor activity IPR022773; Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP) Siva1 Siva Mus musculus (Mouse) TR38789_c0_g1_i1 P42573 CED3_CAEEL 4.00E-35 GO:0030972; GO:0004197; GO:0009792; GO:0016020; GO:0048471; GO:0016540; GO:0042981 Itself; P30429; P30429-2; P41958 cleavage of cytosolic proteins involved in execution phase of apoptosis; cysteine-type endopeptidase activity; embryo development ending in birth or egg hatching; membrane; perinuclear region of cytoplasm; protein autoprocessing; regulation of apoptotic process IPR001315; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Cell death protein 3 (EC 3.4.22.-) [Cleaved into: Cell death protein 3 subunit 1; Cell death protein 3 subunit 2] ced-3 C48D1.2 Caenorhabditis elegans TR38789_c0_g1_i2 P55211 CASP9_HUMAN 6.00E-35 GO:0038095; GO:0017124; GO:0008635; GO:0043293; GO:0034644; GO:0071549; GO:0004197; GO:0008047; GO:0007173; GO:0008543; GO:0045087; GO:0008630; GO:0048011; GO:0005634; GO:0048015; GO:0043065; GO:0043525; GO:0019901; GO:0006508; GO:2001020; GO:0042770 O14727; Q96CA5; Q13418; P98170 Fc-epsilon receptor signaling pathway; SH3 domain binding; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; apoptosome; cellular response to UV; cellular response to dexamethasone stimulus; cysteine-type endopeptidase activity; enzyme activator activity; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; intrinsic apoptotic signaling pathway in response to DNA damage; neurotrophin TRK receptor signaling pathway; nucleus; phosphatidylinositol-mediated signaling; positive regulation of apoptotic process; positive regulation of neuron apoptotic process; protein kinase binding; proteolysis; regulation of response to DNA damage stimulus; signal transduction in response to DNA damage IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] CASP9 MCH6 Homo sapiens (Human) TR38789_c0_g1_i3 O89110 CASP8_MOUSE 1.00E-29 GO:0030690; GO:0006919; GO:0001525; GO:0071260; GO:0005813; GO:0097153; GO:0031264; GO:0008625; GO:0007507; GO:0097284; GO:0030225; GO:0005739; GO:0043124; GO:0060546; GO:0001841; GO:0043123; GO:2001238; GO:0045651; GO:0045862; GO:0051603; GO:0070243; GO:0034612 P10275; P19091; P25446; Q9D8Y7 Noc1p-Noc2p complex; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; death-inducing signaling complex; extrinsic apoptotic signaling pathway via death domain receptors; heart development; hepatocyte apoptotic process; macrophage differentiation; mitochondrion; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of necroptosis; neural tube formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of macrophage differentiation; positive regulation of proteolysis; proteolysis involved in cellular protein catabolic process; regulation of thymocyte apoptotic process; response to tumor necrosis factor IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] Casp8 Mus musculus (Mouse) TR38791_c1_g2_i2 Q8BQB6 F154B_MOUSE 3.00E-48 IPR024963; Protein FAM154B Fam154b Mus musculus (Mouse) TR38791_c1_g2_i3 Q658L1 F154B_HUMAN 3.00E-48 IPR024963; Protein FAM154B FAM154B Homo sapiens (Human) TR38791_c1_g2_i4 Q658L1 F154B_HUMAN 3.00E-48 IPR024963; Protein FAM154B FAM154B Homo sapiens (Human) TR38792_c1_g2_i1 Q5ZMV7 WDR82_CHICK 1.00E-164 GO:0072357; GO:0048188; GO:0000785; GO:0003682; GO:0042800 PTW/PP1 phosphatase complex; Set1C/COMPASS complex; chromatin; chromatin binding; histone methyltransferase activity (H3-K4 specific) IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 82 WDR82 RCJMB04_1b3 Gallus gallus (Chicken) TR38793_c1_g1_i1 Q4LDE5 SVEP1_HUMAN 3.00E-18 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) TR38793_c2_g2_i1 O89026 ROBO1_MOUSE 3.00E-09 GO:0030673; GO:0016199; GO:0016021; GO:0060763; GO:0008285; GO:0021891 axolemma; axon midline choice point recognition; integral to membrane; mammary duct terminal end bud growth; negative regulation of cell proliferation; olfactory bulb interneuron development IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR003596; Roundabout homolog 1 Robo1 Dutt1 Mus musculus (Mouse) TR38794_c0_g2_i1 P74442 Y143_SYNY3 2.00E-14 IPR020472; IPR027417; IPR015943; IPR001680; IPR019775; IPR017986; Uncharacterized WD repeat-containing protein slr0143 slr0143 Synechocystis sp. (strain PCC 6803 / Kazusa) TR38794_c0_g3_i1 Q9P2H3 IFT80_HUMAN 0 GO:0060349; GO:0005813; GO:0035085; GO:0060271; GO:0005932; GO:0001649; GO:0007224 bone morphogenesis; centrosome; cilium axoneme; cilium morphogenesis; microtubule basal body; osteoblast differentiation; smoothened signaling pathway IPR015943; IPR001680; IPR017986; Intraflagellar transport protein 80 homolog (WD repeat-containing protein 56) IFT80 KIAA1374 WDR56 Homo sapiens (Human) TR38794_c0_g3_i2 Q54KL5 WDR5_DICDI 2.00E-12 GO:0051568; GO:0042393; GO:0035097 histone H3-K4 methylation; histone binding; histone methyltransferase complex IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 5 homolog wdr5 DDB_G0287273 Dictyostelium discoideum (Slime mold) TR38794_c0_g3_i3 Q9P2H3 IFT80_HUMAN 0 GO:0060349; GO:0005813; GO:0035085; GO:0060271; GO:0005932; GO:0001649; GO:0007224 bone morphogenesis; centrosome; cilium axoneme; cilium morphogenesis; microtubule basal body; osteoblast differentiation; smoothened signaling pathway IPR015943; IPR001680; IPR017986; Intraflagellar transport protein 80 homolog (WD repeat-containing protein 56) IFT80 KIAA1374 WDR56 Homo sapiens (Human) TR38794_c0_g3_i4 P74442 Y143_SYNY3 4.00E-13 IPR020472; IPR027417; IPR015943; IPR001680; IPR019775; IPR017986; Uncharacterized WD repeat-containing protein slr0143 slr0143 Synechocystis sp. (strain PCC 6803 / Kazusa) TR38795_c2_g1_i3 Q8U3Y2 GYAR_PYRFU 6.00E-26 GO:0051287; GO:0005737; GO:0047964 NAD binding; cytoplasm; glyoxylate reductase activity IPR006139; IPR006140; IPR023519; IPR016040; Glyoxylate reductase (EC 1.1.1.26) gyaR PF0319 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) TR38795_c2_g1_i5 A1RYE4 GYAR_THEPD 4.00E-31 GO:0051287; GO:0005737; GO:0047964 NAD binding; cytoplasm; glyoxylate reductase activity IPR006139; IPR006140; IPR023519; IPR016040; Glyoxylate reductase (EC 1.1.1.26) gyaR Tpen_0823 Thermofilum pendens (strain Hrk 5) TR38795_c2_g2_i2 B1IZP1 GHRB_ECOLC 3.00E-13 GO:0051287; GO:0005737; GO:0030267; GO:0016618; GO:0005886 NAD binding; cytoplasm; glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; plasma membrane IPR006139; IPR006140; IPR023756; IPR016040; Glyoxylate/hydroxypyruvate reductase B (EC 1.1.1.79) (EC 1.1.1.81) ghrB EcolC_0163 Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) TR38797_c1_g1_i1 A2VDW6 NECA3_BOVIN 3.00E-47 GO:0005794; GO:0005509 Golgi apparatus; calcium ion binding IPR007138; IPR011008; IPR011992; IPR018247; IPR002048; N-terminal EF-hand calcium-binding protein 3 (Amyloid beta A4 protein-binding family A member 2-binding protein) (X11L-binding protein 51) NECAB3 APBA2BP XB51 Bos taurus (Bovine) TR38797_c1_g1_i2 Q8BG18 NECA1_MOUSE 3.00E-55 GO:0005509; GO:0005737; GO:0005634 calcium ion binding; cytoplasm; nucleus IPR007138; IPR011008; IPR011992; IPR018247; IPR002048; N-terminal EF-hand calcium-binding protein 1 (EF-hand calcium-binding protein 1) Necab1 Efcbp1 Mus musculus (Mouse) TR38797_c1_g1_i3 Q5R467 NECA1_PONAB 4.00E-54 GO:0005509; GO:0005737 calcium ion binding; cytoplasm IPR007138; IPR011008; IPR011992; IPR018247; IPR002048; N-terminal EF-hand calcium-binding protein 1 (EF-hand calcium-binding protein 1) NECAB1 EFCBP1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38797_c1_g1_i6 Q8BG18 NECA1_MOUSE 2.00E-54 GO:0005509; GO:0005737; GO:0005634 calcium ion binding; cytoplasm; nucleus IPR007138; IPR011008; IPR011992; IPR018247; IPR002048; N-terminal EF-hand calcium-binding protein 1 (EF-hand calcium-binding protein 1) Necab1 Efcbp1 Mus musculus (Mouse) TR38799_c11_g1_i1 Q2VPU4 MLXIP_MOUSE 3.00E-50 GO:0003677; GO:0005737; GO:0005741; GO:0006913; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cytoplasm; mitochondrial outer membrane; nucleocytoplasmic transport; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011598; MLX-interacting protein (Transcriptional activator MondoA) Mlxip Mir Mus musculus (Mouse) TR38799_c11_g2_i1 Q9UH92 MLX_HUMAN 7.00E-06 GO:0003677; GO:0005737; GO:0006112; GO:0045892; GO:0006913; GO:0005634; GO:0031325; GO:0003700; GO:0044281; GO:0006351 "DNA binding; cytoplasm; energy reserve metabolic process; negative regulation of transcription, DNA-dependent; nucleocytoplasmic transport; nucleus; positive regulation of cellular metabolic process; sequence-specific DNA binding transcription factor activity; small molecule metabolic process; transcription, DNA-dependent" IPR011598; Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4) MLX BHLHD13 TCFL4 Homo sapiens (Human) TR38800_c0_g3_i1 Q6Z829 WEE1_ORYSJ 2.00E-52 GO:0005524; GO:0046872; GO:0004715; GO:0018108; GO:0004674 ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Wee1-like protein kinase (EC 2.7.10.2) WEE1 Os02g0135300 LOC_Os02g04240 P0585B01.27 Oryza sativa subsp. japonica (Rice) TR38800_c0_g3_i2 Q8AYK6 WEE1A_XENLA 5.00E-112 GO:0005524; GO:0051301; GO:0000287; GO:0007067; GO:0004715; GO:0005634; GO:0018108; GO:0004674 ATP binding; cell division; magnesium ion binding; mitosis; non-membrane spanning protein tyrosine kinase activity; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; IPR017164; Wee1-like protein kinase 1-A (EC 2.7.10.2) (Zygotic wee1-like protein kinase 2) (XWee2) wee1-a wee2 Xenopus laevis (African clawed frog) TR38801_c2_g3_i1 A5PKH3 FAAA_BOVIN 0 GO:0006559; GO:0004334; GO:0046872; GO:0006572 L-phenylalanine catabolic process; fumarylacetoacetase activity; metal ion binding; tyrosine catabolic process IPR005959; IPR002529; IPR011234; IPR015377; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6. Fumarylacetoacetase (FAA) (EC 3.7.1.2) (Beta-diketonase) (Fumarylacetoacetate hydrolase) FAH Bos taurus (Bovine) TR38801_c2_g3_i2 Q1ZXQ1 FAAA_DICDI 2.00E-173 GO:0006559; GO:0004334; GO:0046872; GO:0006572 L-phenylalanine catabolic process; fumarylacetoacetase activity; metal ion binding; tyrosine catabolic process IPR005959; IPR002529; IPR011234; IPR015377; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6. Fumarylacetoacetase (FAA) (EC 3.7.1.2) (Beta-diketonase) (Fumarylacetoacetate hydrolase) fah DDB_G0271094 Dictyostelium discoideum (Slime mold) TR38802_c1_g1_i1 O43747 AP1G1_HUMAN 2.00E-123 GO:0030119; GO:0000139; GO:0019886; GO:0030131; GO:0030665; GO:0005829; GO:0006897; GO:0006886; GO:0005765; GO:0048471; GO:0006892; GO:0008565; GO:0055037; GO:0050690; GO:0032588; GO:0005215; GO:0016032 Q15276 AP-type membrane coat adaptor complex; Golgi membrane; antigen processing and presentation of exogenous peptide antigen via MHC class II; clathrin adaptor complex; clathrin-coated vesicle membrane; cytosol; endocytosis; intracellular protein transport; lysosomal membrane; perinuclear region of cytoplasm; post-Golgi vesicle-mediated transport; protein transporter activity; recycling endosome; regulation of defense response to virus by virus; trans-Golgi network membrane; transporter activity; viral process IPR017107; IPR011989; IPR016024; IPR002553; IPR008152; IPR008153; IPR013041; AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 subunit gamma-1) (Adaptor protein complex AP-1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) AP1G1 ADTG CLAPG1 Homo sapiens (Human) TR38802_c1_g1_i3 O43747 AP1G1_HUMAN 0 GO:0030119; GO:0000139; GO:0019886; GO:0030131; GO:0030665; GO:0005829; GO:0006897; GO:0006886; GO:0005765; GO:0048471; GO:0006892; GO:0008565; GO:0055037; GO:0050690; GO:0032588; GO:0005215; GO:0016032 Q15276 AP-type membrane coat adaptor complex; Golgi membrane; antigen processing and presentation of exogenous peptide antigen via MHC class II; clathrin adaptor complex; clathrin-coated vesicle membrane; cytosol; endocytosis; intracellular protein transport; lysosomal membrane; perinuclear region of cytoplasm; post-Golgi vesicle-mediated transport; protein transporter activity; recycling endosome; regulation of defense response to virus by virus; trans-Golgi network membrane; transporter activity; viral process IPR017107; IPR011989; IPR016024; IPR002553; IPR008152; IPR008153; IPR013041; AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 subunit gamma-1) (Adaptor protein complex AP-1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) AP1G1 ADTG CLAPG1 Homo sapiens (Human) TR38803_c1_g1_i1 Q8N2E2 VWDE_HUMAN 4.00E-06 GO:0005576 extracellular region IPR000742; IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) TR38803_c1_g2_i1 Q8N2E2 VWDE_HUMAN 4.00E-07 GO:0005576 extracellular region IPR000742; IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) TR38803_c3_g1_i1 Q8N2E2 VWDE_HUMAN 7.00E-06 GO:0005576 extracellular region IPR000742; IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) TR38805_c1_g1_i1 Q5PQZ3 ZNT9_DANRE 2.00E-136 GO:0016021; GO:0000166; GO:0005634; GO:0006355; GO:0006351; GO:0005385 "integral to membrane; nucleotide binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion transmembrane transporter activity" IPR002524; IPR027469; IPR009061; IPR022656; Zinc transporter 9 (ZnT-9) (Solute carrier family 30 member 9) slc30a9 Danio rerio (Zebrafish) (Brachydanio rerio) TR38805_c1_g1_i3 Q6PML9 ZNT9_HUMAN 1.00E-134 GO:0008324; GO:0003682; GO:0005856; GO:0016021; GO:0030374; GO:0000166; GO:0006289; GO:0005634; GO:0045944; GO:0003700; GO:0006351; GO:0006829 "cation transmembrane transporter activity; chromatin binding; cytoskeleton; integral to membrane; ligand-dependent nuclear receptor transcription coactivator activity; nucleotide binding; nucleotide-excision repair; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion transport" IPR002524; IPR027469; IPR009061; IPR022656; Zinc transporter 9 (ZnT-9) (Human embryonic lung protein) (HuEL) (Solute carrier family 30 member 9) SLC30A9 C4orf1 HUEL Homo sapiens (Human) TR38805_c1_g1_i5 Q5PQZ3 ZNT9_DANRE 7.00E-139 GO:0016021; GO:0000166; GO:0005634; GO:0006355; GO:0006351; GO:0005385 "integral to membrane; nucleotide binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion transmembrane transporter activity" IPR002524; IPR027469; IPR009061; IPR022656; Zinc transporter 9 (ZnT-9) (Solute carrier family 30 member 9) slc30a9 Danio rerio (Zebrafish) (Brachydanio rerio) TR38806_c0_g1_i1 O57656 GPDA_TAKRU 2.00E-148 GO:0051287; GO:0005975; GO:0046168; GO:0004367; GO:0009331 NAD binding; carbohydrate metabolic process; glycerol-3-phosphate catabolic process; glycerol-3-phosphate dehydrogenase [NAD+] activity; glycerol-3-phosphate dehydrogenase complex IPR008927; IPR013328; IPR006168; IPR006109; IPR017751; IPR011128; IPR016040; "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD-C) (GPDH-C) (EC 1.1.1.8)" gpd1 lg3p Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR38807_c1_g1_i2 Q7Z3J2 CP062_HUMAN 0 GO:0016021 integral to membrane UPF0505 protein C16orf62 (Esophageal cancer-associated protein) C16orf62 101F10.2 Homo sapiens (Human) TR38808_c1_g1_i4 Q9UP83 COG5_HUMAN 4.00E-106 GO:0000139; GO:0017119; GO:0005829; GO:0006891; GO:0005634; GO:0015031 Q9H9E3; P83436 Golgi membrane; Golgi transport complex; cytosol; intra-Golgi vesicle-mediated transport; nucleus; protein transport IPR019465; Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1) COG5 GOLTC1 GTC90 Homo sapiens (Human) TR38808_c1_g3_i2 Q8C0L8 COG5_MOUSE 0 GO:0000139; GO:0017119; GO:0005829; GO:0006891; GO:0015031 Golgi membrane; Golgi transport complex; cytosol; intra-Golgi vesicle-mediated transport; protein transport IPR019465; Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (Component of oligomeric Golgi complex 5) Cog5 Mus musculus (Mouse) TR38808_c1_g3_i3 Q54HE0 COG5_DICDI 2.00E-47 GO:0000139; GO:0017119; GO:0006891; GO:0015031 Golgi membrane; Golgi transport complex; intra-Golgi vesicle-mediated transport; protein transport IPR019465; Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (Component of oligomeric Golgi complex 5) cog5 DDB_G0289535 Dictyostelium discoideum (Slime mold) TR38809_c1_g1_i3 Q96T52 IMP2L_HUMAN 2.00E-43 GO:0016021; GO:0042720; GO:0005634; GO:0001541; GO:0030728; GO:0008233; GO:0006627; GO:0006508; GO:0008236; GO:0007283 integral to membrane; mitochondrial inner membrane peptidase complex; nucleus; ovarian follicle development; ovulation; peptidase activity; protein processing involved in protein targeting to mitochondrion; proteolysis; serine-type peptidase activity; spermatogenesis IPR000223; IPR019758; IPR028360; IPR019759; IPR015927; Mitochondrial inner membrane protease subunit 2 (EC 3.4.21.-) (IMP2-like protein) IMMP2L Homo sapiens (Human) TR38809_c1_g1_i4 Q96T52 IMP2L_HUMAN 2.00E-43 GO:0016021; GO:0042720; GO:0005634; GO:0001541; GO:0030728; GO:0008233; GO:0006627; GO:0006508; GO:0008236; GO:0007283 integral to membrane; mitochondrial inner membrane peptidase complex; nucleus; ovarian follicle development; ovulation; peptidase activity; protein processing involved in protein targeting to mitochondrion; proteolysis; serine-type peptidase activity; spermatogenesis IPR000223; IPR019758; IPR028360; IPR019759; IPR015927; Mitochondrial inner membrane protease subunit 2 (EC 3.4.21.-) (IMP2-like protein) IMMP2L Homo sapiens (Human) TR38814_c0_g1_i1 P62716 PP2AB_RAT 0 GO:0000775; GO:0005737; GO:0046872; GO:0046580; GO:0043066; GO:0005634; GO:0043161; GO:0006470; GO:0046982; GO:0000159; GO:0004722; GO:0010468; GO:0046677; GO:0042542; GO:0000922 "chromosome, centromeric region; cytoplasm; metal ion binding; negative regulation of Ras protein signal transduction; negative regulation of apoptotic process; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein dephosphorylation; protein heterodimerization activity; protein phosphatase type 2A complex; protein serine/threonine phosphatase activity; regulation of gene expression; response to antibiotic; response to hydrogen peroxide; spindle pole" IPR004843; IPR006186; Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) Ppp2cb Rattus norvegicus (Rat) TR38814_c2_g7_i1 Q64620 PPP6_RAT 4.00E-29 GO:0007049; GO:0005737; GO:0046872; GO:0006470; GO:0004722 cell cycle; cytoplasm; metal ion binding; protein dephosphorylation; protein serine/threonine phosphatase activity IPR004843; IPR006186; "Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) (Protein phosphatase V) (PP-V) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]" Ppp6c Ppv Rattus norvegicus (Rat) TR38816_c0_g1_i1 Q8CHM3 T53I2_RAT 3.00E-09 GO:0016605; GO:0005776; GO:0000045; GO:0031410; GO:0005829; GO:0005634; GO:0010508; GO:0045893; GO:0006351 "PML body; autophagic vacuole; autophagic vacuole assembly; cytoplasmic vesicle; cytosol; nucleus; positive regulation of autophagy; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent" Tumor protein p53-inducible nuclear protein 2 (Diabetes and obesity-regulated gene) (Fragment) Tp53inp2 Dor Trp53inp2 Rattus norvegicus (Rat) TR38816_c0_g1_i4 Q9QXE4 T53I1_MOUSE 2.00E-19 GO:0016605; GO:0016209; GO:0006915; GO:0048102; GO:0005776; GO:0006914; GO:0007050; GO:0034644; GO:0071361; GO:0071447; GO:0072703; GO:0031410; GO:0005829; GO:0030336; GO:0008285; GO:0005634; GO:0043065; GO:2001235; GO:0010508; GO:0045893; GO:0009408; GO:0006351 "PML body; antioxidant activity; apoptotic process; autophagic cell death; autophagic vacuole; autophagy; cell cycle arrest; cellular response to UV; cellular response to ethanol; cellular response to hydroperoxide; cellular response to methyl methanesulfonate; cytoplasmic vesicle; cytosol; negative regulation of cell migration; negative regulation of cell proliferation; nucleus; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of autophagy; positive regulation of transcription, DNA-dependent; response to heat; transcription, DNA-dependent" Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (Thymus-expressed acidic protein) (TEAP) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1) Trp53inp1 Sip Mus musculus (Mouse) TR38816_c0_g1_i5 Q80YE2 T53I1_RAT 3.00E-18 GO:0016605; GO:0016209; GO:0006915; GO:0048102; GO:0005776; GO:0006914; GO:0031410; GO:0005829; GO:0030336; GO:0008285; GO:0005634; GO:0010508; GO:0045893; GO:0006351 "PML body; antioxidant activity; apoptotic process; autophagic cell death; autophagic vacuole; autophagy; cytoplasmic vesicle; cytosol; negative regulation of cell migration; negative regulation of cell proliferation; nucleus; positive regulation of autophagy; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent" Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (Thymus-expressed acidic protein) (TEAP) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1) Trp53inp1 Sip Rattus norvegicus (Rat) TR38816_c0_g1_i6 Q9QXE4 T53I1_MOUSE 2.00E-19 GO:0016605; GO:0016209; GO:0006915; GO:0048102; GO:0005776; GO:0006914; GO:0007050; GO:0034644; GO:0071361; GO:0071447; GO:0072703; GO:0031410; GO:0005829; GO:0030336; GO:0008285; GO:0005634; GO:0043065; GO:2001235; GO:0010508; GO:0045893; GO:0009408; GO:0006351 "PML body; antioxidant activity; apoptotic process; autophagic cell death; autophagic vacuole; autophagy; cell cycle arrest; cellular response to UV; cellular response to ethanol; cellular response to hydroperoxide; cellular response to methyl methanesulfonate; cytoplasmic vesicle; cytosol; negative regulation of cell migration; negative regulation of cell proliferation; nucleus; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of autophagy; positive regulation of transcription, DNA-dependent; response to heat; transcription, DNA-dependent" Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (Thymus-expressed acidic protein) (TEAP) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1) Trp53inp1 Sip Mus musculus (Mouse) TR38816_c0_g1_i7 Q96A56 T53I1_HUMAN 2.00E-16 GO:0016605; GO:0016209; GO:0006915; GO:0048102; GO:0005776; GO:0006914; GO:0007050; GO:0031410; GO:0005829; GO:0030336; GO:0008285; GO:0005634; GO:0010508; GO:0045893; GO:0006950; GO:0006351 "PML body; antioxidant activity; apoptotic process; autophagic cell death; autophagic vacuole; autophagy; cell cycle arrest; cytoplasmic vesicle; cytosol; negative regulation of cell migration; negative regulation of cell proliferation; nucleus; positive regulation of autophagy; positive regulation of transcription, DNA-dependent; response to stress; transcription, DNA-dependent" Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1) TP53INP1 P53DINP1 SIP Homo sapiens (Human) TR38817_c3_g1_i2 Q642H2 CRBL2_DANRE 2.00E-24 GO:0030154; GO:0005634; GO:0045600; GO:0046326; GO:0046889; GO:0045893; GO:0043565; GO:0003700; GO:0006351 "cell differentiation; nucleus; positive regulation of fat cell differentiation; positive regulation of glucose import; positive regulation of lipid biosynthetic process; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; cAMP-responsive element-binding protein-like 2 crebl2 zgc:92620 Danio rerio (Zebrafish) (Brachydanio rerio) TR38817_c3_g1_i3 Q642H2 CRBL2_DANRE 1.00E-25 GO:0030154; GO:0005634; GO:0045600; GO:0046326; GO:0046889; GO:0045893; GO:0043565; GO:0003700; GO:0006351 "cell differentiation; nucleus; positive regulation of fat cell differentiation; positive regulation of glucose import; positive regulation of lipid biosynthetic process; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; cAMP-responsive element-binding protein-like 2 crebl2 zgc:92620 Danio rerio (Zebrafish) (Brachydanio rerio) TR38818_c3_g1_i1 O75146 HIP1R_HUMAN 0 GO:0003779; GO:0030136; GO:0030665; GO:0005905; GO:0005856; GO:0048471; GO:0035091; GO:0006898 Q53HG7 actin binding; clathrin-coated vesicle; clathrin-coated vesicle membrane; coated pit; cytoskeleton; perinuclear region of cytoplasm; phosphatidylinositol binding; receptor-mediated endocytosis IPR011417; IPR008942; IPR013809; IPR002558; Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12) HIP1R HIP12 KIAA0655 Homo sapiens (Human) TR38818_c3_g1_i3 O75146 HIP1R_HUMAN 0 GO:0003779; GO:0030136; GO:0030665; GO:0005905; GO:0005856; GO:0048471; GO:0035091; GO:0006898 Q53HG7 actin binding; clathrin-coated vesicle; clathrin-coated vesicle membrane; coated pit; cytoskeleton; perinuclear region of cytoplasm; phosphatidylinositol binding; receptor-mediated endocytosis IPR011417; IPR008942; IPR013809; IPR002558; Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12) HIP1R HIP12 KIAA0655 Homo sapiens (Human) TR38818_c3_g1_i4 Q9P6L5 SLA2_SCHPO 2.00E-40 GO:0070314; GO:0030479; GO:0051519; GO:0051285; GO:0032153; GO:0034613; GO:0006995; GO:0030866; GO:0006897; GO:0030950; GO:0071852; GO:0031580; GO:0005546; GO:0030674 "G1 to G0 transition; actin cortical patch; activation of bipolar cell growth; cell cortex of cell tip; cell division site; cellular protein localization; cellular response to nitrogen starvation; cortical actin cytoskeleton organization; endocytosis; establishment or maintenance of actin cytoskeleton polarity; fungal-type cell wall organization or biogenesis; membrane raft distribution; phosphatidylinositol-4,5-bisphosphate binding; protein binding, bridging" IPR011417; IPR008942; IPR013809; IPR002558; Endocytosis protein end4 (SLA2 protein homolog) end4 sla2 SPAC688.11 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38818_c3_g1_i6 Q71LX4 TLN2_MOUSE 4.00E-15 GO:0015629; GO:0007155; GO:0005737; GO:0007016; GO:0005916; GO:0005925; GO:0005886; GO:0001726; GO:0005200; GO:0045202 actin cytoskeleton; cell adhesion; cytoplasm; cytoskeletal anchoring at plasma membrane; fascia adherens; focal adhesion; plasma membrane; ruffle; structural constituent of cytoskeleton; synapse IPR019749; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR002558; IPR002404; IPR011993; IPR015711; IPR015224; IPR015009; IPR006077; Talin-2 Tln2 Mus musculus (Mouse) TR38819_c4_g2_i4 Q96BD0 SO4A1_HUMAN 3.00E-61 GO:0016021; GO:0005886; GO:0043252; GO:0055085; GO:0005215 integral to membrane; plasma membrane; sodium-independent organic anion transport; transmembrane transport; transporter activity IPR002350; IPR020846; IPR016196; IPR004156; Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) SLCO4A1 OATP1 OATP4A1 OATPE SLC21A12 Homo sapiens (Human) TR38819_c5_g1_i1 Q9WV54 ASAH1_MOUSE 1.00E-78 GO:0017040; GO:0006629; GO:0030324; GO:0005764; GO:0010033 ceramidase activity; lipid metabolic process; lung development; lysosome; response to organic substance IPR016699; IPR003199; Acid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (N-acylsphingosine amidohydrolase) [Cleaved into: Acid ceramidase subunit alpha; Acid ceramidase subunit beta] Asah1 Asah Mus musculus (Mouse) TR38819_c5_g1_i2 A5A6P2 ASAH1_PANTR 1.00E-140 GO:0017040; GO:0006629; GO:0005764 ceramidase activity; lipid metabolic process; lysosome IPR016699; IPR003199; Acid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (N-acylsphingosine amidohydrolase) ASAH1 Pan troglodytes (Chimpanzee) TR38820_c0_g1_i2 Q95SX7 RTBS_DROME 5.00E-21 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR38820_c0_g1_i5 Q95SX7 RTBS_DROME 5.00E-21 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR38821_c0_g1_i1 Q5XH94 TIM23_XENTR 2.00E-27 GO:0015450; GO:0016021; GO:0006886; GO:0005744 P-P-bond-hydrolysis-driven protein transmembrane transporter activity; integral to membrane; intracellular protein transport; mitochondrial inner membrane presequence translocase complex IPR003397; IPR005681; Mitochondrial import inner membrane translocase subunit Tim23 timm23 timm23b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38821_c0_g1_i3 Q5XH94 TIM23_XENTR 2.00E-27 GO:0015450; GO:0016021; GO:0006886; GO:0005744 P-P-bond-hydrolysis-driven protein transmembrane transporter activity; integral to membrane; intracellular protein transport; mitochondrial inner membrane presequence translocase complex IPR003397; IPR005681; Mitochondrial import inner membrane translocase subunit Tim23 timm23 timm23b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38823_c0_g1_i1 B5YI39 CLPX_THEYD 2.00E-83 GO:0005524; GO:0017111; GO:0006457; GO:0008270 ATP binding; nucleoside-triphosphatase activity; protein folding; zinc ion binding IPR003593; IPR013093; IPR019489; IPR004487; IPR027417; IPR010603; ATP-dependent Clp protease ATP-binding subunit ClpX clpX THEYE_A0256 Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87) TR38823_c0_g1_i2 Q9JHS4 CLPX_MOUSE 7.00E-94 GO:0005524; GO:0004176; GO:0016887; GO:0046872; GO:0009841; GO:0005743; GO:0042645; GO:0016504; GO:0006457; GO:0051603 ATP binding; ATP-dependent peptidase activity; ATPase activity; metal ion binding; mitochondrial endopeptidase Clp complex; mitochondrial inner membrane; mitochondrial nucleoid; peptidase activator activity; protein folding; proteolysis involved in cellular protein catabolic process IPR003593; IPR013093; IPR019489; IPR004487; IPR027417; "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial" Clpx Mus musculus (Mouse) TR38823_c0_g1_i3 Q74JU4 CLPX_LACJO 1.00E-88 GO:0005524; GO:0017111; GO:0006457; GO:0008270 ATP binding; nucleoside-triphosphatase activity; protein folding; zinc ion binding IPR003593; IPR013093; IPR019489; IPR004487; IPR027417; IPR010603; ATP-dependent Clp protease ATP-binding subunit ClpX clpX LJ_1011 Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533) TR38824_c1_g1_i2 P07686 HEXB_HUMAN 7.00E-129 GO:0001669; GO:0043615; GO:0004563; GO:0005975; GO:0008219; GO:0006874; GO:0044267; GO:0030207; GO:0006689; GO:0006687; GO:0030214; GO:0042340; GO:0019915; GO:0007626; GO:0043202; GO:0007040; GO:0008049; GO:0016020; GO:0042552; GO:0050885; GO:0009313; GO:0048477; GO:0007341; GO:0008654; GO:0045944; GO:0046982; GO:0042803; GO:0008360; GO:0007605; GO:0001501 acrosomal vesicle; astrocyte cell migration; beta-N-acetylhexosaminidase activity; carbohydrate metabolic process; cell death; cellular calcium ion homeostasis; cellular protein metabolic process; chondroitin sulfate catabolic process; ganglioside catabolic process; glycosphingolipid metabolic process; hyaluronan catabolic process; keratan sulfate catabolic process; lipid storage; locomotory behavior; lysosomal lumen; lysosome organization; male courtship behavior; membrane; myelination; neuromuscular process controlling balance; oligosaccharide catabolic process; oogenesis; penetration of zona pellucida; phospholipid biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; protein homodimerization activity; regulation of cell shape; sensory perception of sound; skeletal system development IPR025705; IPR015883; IPR013781; IPR017853; Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] HEXB HCC7 Homo sapiens (Human) TR38826_c0_g1_i1 Q8C854 MYEF2_MOUSE 3.00E-53 GO:0003677; GO:0003723; GO:0000166; GO:0005634; GO:0006351 "DNA binding; RNA binding; nucleotide binding; nucleus; transcription, DNA-dependent" IPR012677; IPR000504; Myelin expression factor 2 (MEF-2) (MyEF-2) Myef2 Kiaa1341 Mef2 Mus musculus (Mouse) TR38826_c0_g1_i2 O13845 RSD1_SCHPO 8.00E-06 GO:0003723; GO:0045292; GO:0000166; GO:0005681 "RNA binding; mRNA cis splicing, via spliceosome; nucleotide binding; spliceosomal complex" IPR006509; IPR012677; IPR000504; RNA-binding protein rsd1 rsd1 SPAC19G12.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38826_c0_g1_i4 Q8C854 MYEF2_MOUSE 3.00E-53 GO:0003677; GO:0003723; GO:0000166; GO:0005634; GO:0006351 "DNA binding; RNA binding; nucleotide binding; nucleus; transcription, DNA-dependent" IPR012677; IPR000504; Myelin expression factor 2 (MEF-2) (MyEF-2) Myef2 Kiaa1341 Mef2 Mus musculus (Mouse) TR38828_c8_g2_i2 Q6FPT9 SNX4_CANGA 1.00E-14 GO:0006914; GO:0007154; GO:0010008; GO:0035091; GO:0015031 autophagy; cell communication; endosome membrane; phosphatidylinositol binding; protein transport IPR001683; Sorting nexin-4 (Autophagy-related protein 24) SNX4 ATG24 CAGL0J01001g Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) TR38828_c8_g2_i3 Q9CWK8 SNX2_MOUSE 5.00E-169 GO:0007154; GO:0031901; GO:0010008; GO:0006886; GO:0035091; GO:0008565 cell communication; early endosome membrane; endosome membrane; intracellular protein transport; phosphatidylinositol binding; protein transporter activity IPR001683; IPR005329; IPR015404; Sorting nexin-2 Snx2 Mus musculus (Mouse) TR38828_c8_g2_i8 Q9CWK8 SNX2_MOUSE 8.00E-169 GO:0007154; GO:0031901; GO:0010008; GO:0006886; GO:0035091; GO:0008565 cell communication; early endosome membrane; endosome membrane; intracellular protein transport; phosphatidylinositol binding; protein transporter activity IPR001683; IPR005329; IPR015404; Sorting nexin-2 Snx2 Mus musculus (Mouse) TR38829_c0_g1_i1 Q26627 SUREJ_STRPU 1.00E-06 GO:0030246; GO:0016021; GO:0007218; GO:0005886 carbohydrate binding; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR001304; IPR016186; IPR016187; IPR000742; IPR013032; IPR000152; IPR000203; IPR002859; IPR014010; Sperm receptor for egg jelly (suREJ) REJ Strongylocentrotus purpuratus (Purple sea urchin) TR38829_c0_g1_i2 P10079 FBP1_STRPU 7.00E-158 GO:0032579; GO:0005509; GO:0016023; GO:0005615 apical lamina of hyaline layer; calcium ion binding; cytoplasmic membrane-bounded vesicle; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) TR38829_c0_g1_i3 Q01705 NOTC1_MOUSE 7.00E-148 GO:0000139; GO:0002193; GO:0003270; GO:0001190; GO:0042640; GO:0003180; GO:1902263; GO:0060842; GO:0003162; GO:0003181; GO:0009912; GO:0007409; GO:0048754; GO:0005509; GO:0003214; GO:0060038; GO:0003213; GO:0003219; GO:0060411; GO:0060948; GO:0001708; GO:0003273; GO:0009986; GO:0071372; GO:0035924; GO:0031490; GO:0072044; GO:0007386; GO:0001047; GO:0060982; GO:0003169; GO:0005856; GO:0005829; GO:0072017; GO:0035116; GO:0060956; GO:0003160; GO:0007492; GO:0005789; GO:0004857; GO:0003198; GO:0005576; GO:0030900; GO:0007440; GO:0010001; GO:0072144; GO:0003241; GO:0031069; GO:0001947; GO:0006959; GO:0001701; GO:0002437; GO:0005887; GO:0072602; GO:0030216; GO:0030027; GO:0070986; GO:0001889; GO:0030324; GO:0003192; GO:0030514; GO:2000811; GO:0045955; GO:0090090; GO:0060548; GO:0090051; GO:0010812; GO:2001027; GO:0060253; GO:0045662; GO:0010832; GO:0048715; GO:0030279; GO:0045668; GO:0046533; GO:2000974; GO:2000737; GO:0000122; GO:0021915; GO:0097150; GO:0005654; GO:0002051; GO:0003344; GO:0030513; GO:0046427; GO:0043065; GO:0048711; GO:0060045; GO:0030335; GO:1901189; GO:0050679; GO:0010718; GO:0045618; GO:0061419; GO:0007221; GO:0060740; GO:0003184; GO:0004872; GO:0061344; GO:0060768; GO:1901201; GO:0014807; GO:0003256; GO:0032495; GO:0001726; GO:0060528; GO:0043565; GO:0003700; GO:0035914; GO:0048103; GO:0002040; GO:0035148; GO:0060979; GO:0060843; GO:0060412; GO:0003222 Q06330; P31266; P28159 Golgi membrane; MAML1-RBP-Jkappa- ICN1 complex; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation; RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; anagen; aortic valve morphogenesis; apoptotic process involved in embryonic digit morphogenesis; arterial endothelial cell differentiation; atrioventricular node development; atrioventricular valve morphogenesis; auditory receptor cell fate commitment; axonogenesis; branching morphogenesis of an epithelial tube; calcium ion binding; cardiac left ventricle morphogenesis; cardiac muscle cell proliferation; cardiac right atrium morphogenesis; cardiac right ventricle formation; cardiac septum morphogenesis; cardiac vascular smooth muscle cell development; cell fate specification; cell migration involved in endocardial cushion formation; cell surface; cellular response to follicle-stimulating hormone stimulus; cellular response to vascular endothelial growth factor stimulus; chromatin DNA binding; collecting duct development; compartment pattern specification; core promoter binding; coronary artery morphogenesis; coronary vein morphogenesis; cytoskeleton; cytosol; distal tubule development; embryonic hindlimb morphogenesis; endocardial cell differentiation; endocardium morphogenesis; endoderm development; endoplasmic reticulum membrane; enzyme inhibitor activity; epithelial to mesenchymal transition involved in endocardial cushion formation; extracellular region; forebrain development; foregut morphogenesis; glial cell differentiation; glomerular mesangial cell development; growth involved in heart morphogenesis; hair follicle morphogenesis; heart looping; humoral immune response; in utero embryonic development; inflammatory response to antigenic stimulus; integral to plasma membrane; interleukin-4 secretion; keratinocyte differentiation; lamellipodium; left/right axis specification; liver development; lung development; mitral valve formation; negative regulation of BMP signaling pathway; negative regulation of anoikis; negative regulation of calcium ion-dependent exocytosis; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of cell death; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell-substrate adhesion; negative regulation of endothelial cell chemotaxis; negative regulation of glial cell proliferation; negative regulation of myoblast differentiation; negative regulation of myotube differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of ossification; negative regulation of osteoblast differentiation; negative regulation of photoreceptor cell differentiation; negative regulation of pro-B cell differentiation; negative regulation of stem cell differentiation; negative regulation of transcription from RNA polymerase II promoter; neural tube development; neuronal stem cell maintenance; nucleoplasm; osteoblast fate commitment; pericardium morphogenesis; positive regulation of BMP signaling pathway; positive regulation of JAK-STAT cascade; positive regulation of apoptotic process; positive regulation of astrocyte differentiation; positive regulation of cardiac muscle cell proliferation; positive regulation of cell migration; positive regulation of ephrin receptor signaling pathway; positive regulation of epithelial cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription of Notch receptor target; prostate gland epithelium morphogenesis; pulmonary valve morphogenesis; receptor activity; regulation of cell adhesion involved in heart morphogenesis; regulation of epithelial cell proliferation involved in prostate gland development; regulation of extracellular matrix assembly; regulation of somitogenesis; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation; response to muramyl dipeptide; ruffle; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; skeletal muscle cell differentiation; somatic stem cell division; sprouting angiogenesis; tube formation; vasculogenesis involved in coronary vascular morphogenesis; venous endothelial cell differentiation; ventricular septum morphogenesis; ventricular trabecula myocardium morphogenesis IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022362; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 1 (Notch 1) (Motch A) (mT14) (p300) [Cleaved into: Notch 1 extracellular truncation; Notch 1 intracellular domain (NICD)] Notch1 Motch Mus musculus (Mouse) TR38830_c0_g1_i1 Q8IYB1 M21D2_HUMAN 5.00E-18 IPR024810; IPR024803; Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) TR38832_c1_g1_i1 Q4R7Q5 PICK1_MACFA 6.00E-111 GO:0030054; GO:0046872; GO:0048471; GO:0045202 cell junction; metal ion binding; perinuclear region of cytoplasm; synapse IPR027267; IPR010504; IPR001478; PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein) PICK1 PRKCABP QtsA-14644 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38832_c1_g1_i3 Q4R7Q5 PICK1_MACFA 1.00E-113 GO:0030054; GO:0046872; GO:0048471; GO:0045202 cell junction; metal ion binding; perinuclear region of cytoplasm; synapse IPR027267; IPR010504; IPR001478; PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein) PICK1 PRKCABP QtsA-14644 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38833_c0_g1_i1 Q7ZX31 ING3_XENLA 5.00E-54 GO:0043968; GO:0043967; GO:0005634; GO:0043065; GO:0040008; GO:0006355; GO:0006351; GO:0008270 "histone H2A acetylation; histone H4 acetylation; nucleus; positive regulation of apoptotic process; regulation of growth; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR024610; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Inhibitor of growth protein 3 ing3 Xenopus laevis (African clawed frog) TR38833_c0_g3_i2 B3H615 ING2_ARATH 2.00E-17 GO:0016568; GO:0035064; GO:0005634; GO:0040008; GO:0006355; GO:0006351; GO:0008270 "chromatin modification; methylated histone residue binding; nucleus; regulation of growth; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR024610; IPR011011; IPR001965; IPR019787; IPR013083; PHD finger protein ING2 (Protein INHIBITOR OF GROWTH 2) (Protein AtING2) ING2 At1g54390 F20D21.22 Arabidopsis thaliana (Mouse-ear cress) TR38833_c0_g3_i3 Q9QXV3 ING1_MOUSE 2.00E-26 GO:0007049; GO:0005634; GO:0045893; GO:0006606; GO:0010941; GO:0008270 "cell cycle; nucleus; positive regulation of transcription, DNA-dependent; protein import into nucleus; regulation of cell death; zinc ion binding" IPR024610; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Inhibitor of growth protein 1 Ing1 Mus musculus (Mouse) TR38833_c0_g3_i4 Q5RBA1 ING3_PONAB 6.00E-38 GO:0032777; GO:0043968; GO:0043967; GO:0043065; GO:0040008; GO:0006355; GO:0006351; GO:0008270 "Piccolo NuA4 histone acetyltransferase complex; histone H2A acetylation; histone H4 acetylation; positive regulation of apoptotic process; regulation of growth; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR024610; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Inhibitor of growth protein 3 ING3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38834_c1_g2_i1 P21329 RTJK_DROFU 6.00E-29 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) TR38834_c1_g2_i6 Q10126 YSM6_CAEEL 8.00E-09 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR000477; Putative uncharacterized transposon-derived protein F52C9.6 F52C9.6 Caenorhabditis elegans TR38834_c1_g2_i7 P21329 RTJK_DROFU 4.00E-29 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) TR38835_c1_g1_i2 P84082 ARF2_RAT 3.00E-116 GO:0005525; GO:0005794; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor 2 Arf2 Rattus norvegicus (Rat) TR38836_c2_g2_i1 Q8WUB8 PHF10_HUMAN 6.00E-69 GO:0007399; GO:0071564; GO:0006355; GO:0006351; GO:0008270 "nervous system development; npBAF complex; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR011011; IPR001965; IPR019787; IPR013083; PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) PHF10 BAF45A Homo sapiens (Human) TR38836_c2_g2_i2 A9LMC0 DPF3_DANRE 1.00E-23 GO:0016514; GO:0055008; GO:0016568; GO:0042393; GO:0007399; GO:0006355; GO:0006351; GO:0008270 "SWI/SNF complex; cardiac muscle tissue morphogenesis; chromatin modification; histone binding; nervous system development; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR025750; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Zinc finger protein DPF3 dpf3 si:ch211-268e23.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR38836_c2_g2_i3 Q8NEZ4 MLL3_HUMAN 6.00E-17 GO:0003677; GO:0042800; GO:0035097; GO:0035556; GO:0006355; GO:0006351; GO:0008270 Q14686 "DNA binding; histone methyltransferase activity (H3-K4 specific); histone methyltransferase complex; intracellular signal transduction; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR017956; IPR003889; IPR003888; IPR009071; IPR000637; IPR003616; IPR002219; IPR001214; IPR001594; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.43) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) KMT2C HALR KIAA1506 MLL3 Homo sapiens (Human) TR38836_c2_g2_i5 Q80Y84 KDM5B_MOUSE 7.00E-07 GO:0003677; GO:0034648; GO:0034647; GO:0045892; GO:0005730; GO:0016706; GO:0003714; GO:0006351; GO:0008270 P60762 "DNA binding; histone demethylase activity (H3-dimethyl-K4 specific); histone demethylase activity (H3-trimethyl-K4 specific); negative regulation of transcription, DNA-dependent; nucleolus; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; transcription corepressor activity; transcription, DNA-dependent; zinc ion binding" IPR001606; IPR003347; IPR013637; IPR003349; IPR019786; IPR004198; IPR011011; IPR001965; IPR019787; IPR013083; Lysine-specific demethylase 5B (EC 1.14.11.-) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) Kdm5b Jarid1b Kiaa4034 Plu1 Mus musculus (Mouse) TR38836_c2_g2_i6 O88379 BAZ1A_MOUSE 8.00E-08 GO:0006338; GO:0000228; GO:0006355; GO:0006351; GO:0008270 "chromatin remodeling; nuclear chromosome; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001487; IPR018359; IPR004022; IPR018501; IPR013136; IPR019786; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Bromodomain adjacent to zinc finger domain protein 1A (Cbp146) Baz1a Cbp146 Mus musculus (Mouse) TR38837_c0_g1_i1 Q62824 EXOC4_RAT 1.00E-172 GO:0055108; GO:0030165; GO:0043198; GO:0030010; GO:0000145; GO:0030426; GO:0044091; GO:0043209; GO:0043025; GO:0048709; GO:0050850; GO:0014069; GO:0032403; GO:0006612; GO:0051223; GO:0007268; GO:0006904; GO:0006903 Golgi to transport vesicle transport; PDZ domain binding; dendritic shaft; establishment of cell polarity; exocyst; growth cone; membrane biogenesis; myelin sheath; neuronal cell body; oligodendrocyte differentiation; positive regulation of calcium-mediated signaling; postsynaptic density; protein complex binding; protein targeting to membrane; regulation of protein transport; synaptic transmission; vesicle docking involved in exocytosis; vesicle targeting IPR007191; Exocyst complex component 4 (Exocyst complex component Sec8) (rSec8) Exoc4 Sec8 Sec8l1 Rattus norvegicus (Rat) TR38837_c0_g1_i2 Q54P76 EXOC4_DICDI 8.00E-15 GO:0000145; GO:0015031; GO:0006904 exocyst; protein transport; vesicle docking involved in exocytosis IPR007191; Exocyst complex component 4 (Exocyst complex component Sec8) exoc4 sec8 DDB_G0284833 Dictyostelium discoideum (Slime mold) TR38837_c0_g1_i3 Q96A65 EXOC4_HUMAN 2.00E-174 GO:0044267; GO:0005737; GO:0000145; GO:0032584; GO:0035748; GO:0005886; GO:0015031; GO:0006904 Q9NR09 cellular protein metabolic process; cytoplasm; exocyst; growth cone membrane; myelin sheath abaxonal region; plasma membrane; protein transport; vesicle docking involved in exocytosis IPR007191; Exocyst complex component 4 (Exocyst complex component Sec8) EXOC4 KIAA1699 SEC8 SEC8L1 Homo sapiens (Human) TR38837_c0_g1_i4 Q62824 EXOC4_RAT 9.00E-175 GO:0055108; GO:0030165; GO:0043198; GO:0030010; GO:0000145; GO:0030426; GO:0044091; GO:0043209; GO:0043025; GO:0048709; GO:0050850; GO:0014069; GO:0032403; GO:0006612; GO:0051223; GO:0007268; GO:0006904; GO:0006903 Golgi to transport vesicle transport; PDZ domain binding; dendritic shaft; establishment of cell polarity; exocyst; growth cone; membrane biogenesis; myelin sheath; neuronal cell body; oligodendrocyte differentiation; positive regulation of calcium-mediated signaling; postsynaptic density; protein complex binding; protein targeting to membrane; regulation of protein transport; synaptic transmission; vesicle docking involved in exocytosis; vesicle targeting IPR007191; Exocyst complex component 4 (Exocyst complex component Sec8) (rSec8) Exoc4 Sec8 Sec8l1 Rattus norvegicus (Rat) TR38837_c0_g1_i6 Q9HE88 SEC8_NEUCR 6.00E-21 GO:0000145; GO:0015031; GO:0006904 exocyst; protein transport; vesicle docking involved in exocytosis IPR007191; Probable exocyst complex component sec8 sec-8 B13O20.150 NCU04190 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR38837_c0_g2_i1 Q62824 EXOC4_RAT 6.00E-54 GO:0055108; GO:0030165; GO:0043198; GO:0030010; GO:0000145; GO:0030426; GO:0044091; GO:0043209; GO:0043025; GO:0048709; GO:0050850; GO:0014069; GO:0032403; GO:0006612; GO:0051223; GO:0007268; GO:0006904; GO:0006903 Golgi to transport vesicle transport; PDZ domain binding; dendritic shaft; establishment of cell polarity; exocyst; growth cone; membrane biogenesis; myelin sheath; neuronal cell body; oligodendrocyte differentiation; positive regulation of calcium-mediated signaling; postsynaptic density; protein complex binding; protein targeting to membrane; regulation of protein transport; synaptic transmission; vesicle docking involved in exocytosis; vesicle targeting IPR007191; Exocyst complex component 4 (Exocyst complex component Sec8) (rSec8) Exoc4 Sec8 Sec8l1 Rattus norvegicus (Rat) TR38838_c2_g1_i1 Q80YA7 DPP8_MOUSE 0 GO:0004177; GO:0005737; GO:0016020; GO:0006508; GO:0008236 aminopeptidase activity; cytoplasm; membrane; proteolysis; serine-type peptidase activity IPR001375; IPR002469; Dipeptidyl peptidase 8 (DP8) (EC 3.4.14.5) (Dipeptidyl peptidase VIII) (DPP VIII) Dpp8 Mus musculus (Mouse) TR38841_c1_g1_i1 P10950 ASMT_BOVIN 6.00E-33 GO:0017096; GO:0030187 acetylserotonin O-methyltransferase activity; melatonin biosynthetic process IPR025781; IPR016461; IPR001077; IPR011991; Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2. Acetylserotonin O-methyltransferase (EC 2.1.1.4) (Hydroxyindole O-methyltransferase) (HIOMT) ASMT Bos taurus (Bovine) TR38848_c0_g1_i1 Q2KJC9 AL7A1_BOVIN 0 GO:0004043; GO:0008802; GO:0005829; GO:0019285; GO:0005739; GO:0005634 L-aminoadipate-semialdehyde dehydrogenase activity; betaine-aldehyde dehydrogenase activity; cytosol; glycine betaine biosynthetic process from choline; mitochondrion; nucleus IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) ALDH7A1 Bos taurus (Bovine) TR38848_c0_g1_i2 Q9SYG7 AL7B4_ARATH 0 GO:0004029; GO:0006081; GO:0005829; GO:0009737; GO:0009269; GO:0009651 aldehyde dehydrogenase (NAD) activity; cellular aldehyde metabolic process; cytosol; response to abscisic acid stimulus; response to desiccation; response to salt stress IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Aldehyde dehydrogenase family 7 member B4 (EC 1.2.1.3) (Antiquitin-1) (Turgor-responsive ALDH) ALDH7B4 At1g54100 F15I1.19 Arabidopsis thaliana (Mouse-ear cress) TR38848_c0_g1_i3 Q2KJC9 AL7A1_BOVIN 0 GO:0004043; GO:0008802; GO:0005829; GO:0019285; GO:0005739; GO:0005634 L-aminoadipate-semialdehyde dehydrogenase activity; betaine-aldehyde dehydrogenase activity; cytosol; glycine betaine biosynthetic process from choline; mitochondrion; nucleus IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) ALDH7A1 Bos taurus (Bovine) TR38848_c0_g1_i5 Q02DY9 BETB_PSEAB 1.00E-53 GO:0008802; GO:0019285; GO:0046872 betaine-aldehyde dehydrogenase activity; glycine betaine biosynthetic process from choline; metal ion binding IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR011264; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. NAD/NADP-dependent betaine aldehyde dehydrogenase (BADH) (EC 1.2.1.8) betB PA14_70950 Pseudomonas aeruginosa (strain UCBPP-PA14) TR38848_c0_g1_i6 Q9SYG7 AL7B4_ARATH 0 GO:0004029; GO:0006081; GO:0005829; GO:0009737; GO:0009269; GO:0009651 aldehyde dehydrogenase (NAD) activity; cellular aldehyde metabolic process; cytosol; response to abscisic acid stimulus; response to desiccation; response to salt stress IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Aldehyde dehydrogenase family 7 member B4 (EC 1.2.1.3) (Antiquitin-1) (Turgor-responsive ALDH) ALDH7B4 At1g54100 F15I1.19 Arabidopsis thaliana (Mouse-ear cress) TR38849_c1_g1_i2 Q9D5V6 SYAP1_MOUSE 1.00E-70 GO:0005634 nucleus IPR005607; Synapse-associated protein 1 Syap1 Mus musculus (Mouse) TR38849_c1_g1_i3 Q96A49 SYAP1_HUMAN 1.00E-09 GO:0005634 nucleus IPR005607; Synapse-associated protein 1 SYAP1 PRO3113 Homo sapiens (Human) TR38850_c6_g2_i5 Q5ZM72 FACR1_CHICK 4.00E-87 GO:0008611; GO:0080019; GO:0046474; GO:0016021; GO:0035336; GO:0005778; GO:0010025 ether lipid biosynthetic process; fatty-acyl-CoA reductase (alcohol-forming) activity; glycerophospholipid biosynthetic process; integral to membrane; long-chain fatty-acyl-CoA metabolic process; peroxisomal membrane; wax biosynthetic process IPR026055; IPR013120; IPR016040; Fatty acyl-CoA reductase 1 (EC 1.2.1.n2) (Male sterility domain-containing protein 2) FAR1 MLSTD2 RCJMB04_2p4 Gallus gallus (Chicken) TR38850_c6_g3_i1 Q960W6 FACR3_DROME 2.00E-55 GO:0080019; GO:0016021; GO:0006629; GO:0050062; GO:0005777; GO:0010025 fatty-acyl-CoA reductase (alcohol-forming) activity; integral to membrane; lipid metabolic process; long-chain-fatty-acyl-CoA reductase activity; peroxisome; wax biosynthetic process IPR026055; IPR013120; IPR016040; Putative fatty acyl-CoA reductase CG8306 (EC 1.2.1.n2) CG8306 Drosophila melanogaster (Fruit fly) TR38852_c1_g2_i2 P20273 CD22_HUMAN 3.00E-08 GO:0007155; GO:0009897; GO:0005887 P07948; P19174; P29350; P43405 cell adhesion; external side of plasma membrane; integral to plasma membrane IPR013162; IPR007110; IPR013783; IPR003599; IPR003598; IPR013151; B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) TR38852_c1_g2_i3 Q9R044 NPHN_RAT 2.00E-17 GO:0007155; GO:0003094; GO:0016021; GO:0045121; GO:0007517; GO:0005886; GO:0043234; GO:0036057 P97710 cell adhesion; glomerular filtration; integral to membrane; membrane raft; muscle organ development; plasma membrane; protein complex; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Rattus norvegicus (Rat) TR38853_c5_g2_i1 P22699 GUN6_DICDI 3.00E-47 GO:0008810; GO:0030245; GO:0030435 cellulase activity; cellulose catabolic process; sporulation resulting in formation of a cellular spore IPR008928; IPR012341; IPR001701; IPR018221; "Endoglucanase (EC 3.2.1.4) (Cellulase) (Endo-1,4-beta-glucanase) (Spore germination protein 270-6)" celA DDB_G0271134 Dictyostelium discoideum (Slime mold) TR38855_c0_g2_i1 Q9UIF7 MUTYH_HUMAN 3.00E-133 GO:0051539; GO:0032407; GO:0045007; GO:0016798; GO:0046872; GO:0006298; GO:0005739; GO:0005654 "4 iron, 4 sulfur cluster binding; MutSalpha complex binding; depurination; hydrolase activity, acting on glycosyl bonds; metal ion binding; mismatch repair; mitochondrion; nucleoplasm" IPR005760; IPR011257; IPR004036; IPR004035; IPR003651; IPR003265; IPR023170; IPR000086; IPR015797; A/G-specific adenine DNA glycosylase (EC 3.2.2.-) (MutY homolog) (hMYH) MUTYH MYH Homo sapiens (Human) TR38855_c0_g2_i2 P46303 UVEN_MICLC 2.00E-07 GO:0051539; GO:0003677; GO:0003906; GO:0006284; GO:0004519; GO:0016798; GO:0046872; GO:0090305 "4 iron, 4 sulfur cluster binding; DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; base-excision repair; endonuclease activity; hydrolase activity, acting on glycosyl bonds; metal ion binding; nucleic acid phosphodiester bond hydrolysis" IPR011257; IPR004036; IPR005759; IPR004035; IPR003651; IPR003265; IPR000445; IPR003583; IPR023170; Ultraviolet N-glycosylase/AP lyase (Pyrimidine dimer glycosylase) (UV-endonuclease) [Cleaved into: UV endonuclease 32 kDa isoform; UV endonuclease 31 kDa isoform] pdg Mlut_18220 Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus) TR38857_c0_g1_i1 P12815 PDCD6_MOUSE 4.00E-80 GO:0006919; GO:0001525; GO:0060090; GO:0005509; GO:0033554; GO:0005737; GO:0031410; GO:0005789; GO:0005768; GO:0006886; GO:0032007; GO:0051898; GO:0030948; GO:0031965; GO:0045766; GO:0010595; GO:0001938; GO:0051592; GO:0036324 P25445; Q8N114 "activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; binding, bridging; calcium ion binding; cellular response to stress; cytoplasm; cytoplasmic vesicle; endoplasmic reticulum membrane; endosome; intracellular protein transport; negative regulation of TOR signaling cascade; negative regulation of protein kinase B signaling cascade; negative regulation of vascular endothelial growth factor receptor signaling pathway; nuclear membrane; positive regulation of angiogenesis; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; response to calcium ion; vascular endothelial growth factor receptor-2 signaling pathway" IPR011992; IPR018247; IPR002048; Programmed cell death protein 6 (ALG-257) (PMP41) (Probable calcium-binding protein ALG-2) Pdcd6 Alg2 Mus musculus (Mouse) TR38858_c0_g1_i2 P30044 PRDX5_HUMAN 3.00E-63 GO:0070995; GO:0001016; GO:0016209; GO:0034614; GO:0043027; GO:0031410; GO:0005829; GO:0042744; GO:0006954; GO:0005739; GO:0043066; GO:0051354; GO:0016480; GO:0005634; GO:0048471; GO:0004601; GO:0051920; GO:0005782; GO:0005777; GO:0072541; GO:0032967; GO:0046983; GO:2001057; GO:0060785 NADPH oxidation; RNA polymerase III regulatory region DNA binding; antioxidant activity; cellular response to reactive oxygen species; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasmic vesicle; cytosol; hydrogen peroxide catabolic process; inflammatory response; mitochondrion; negative regulation of apoptotic process; negative regulation of oxidoreductase activity; negative regulation of transcription from RNA polymerase III promoter; nucleus; perinuclear region of cytoplasm; peroxidase activity; peroxiredoxin activity; peroxisomal matrix; peroxisome; peroxynitrite reductase activity; positive regulation of collagen biosynthetic process; protein dimerization activity; reactive nitrogen species metabolic process; regulation of apoptosis involved in tissue homeostasis IPR013740; IPR012336; "Peroxiredoxin-5, mitochondrial (EC 1.11.1.15) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin reductase)" PRDX5 ACR1 SBBI10 Homo sapiens (Human) TR38858_c0_g1_i3 Q9XEX2 PRX2B_ARATH 2.00E-34 GO:0009507; GO:0005829; GO:0004601; GO:0051920; GO:0005886; GO:0046686 chloroplast; cytosol; peroxidase activity; peroxiredoxin activity; plasma membrane; response to cadmium ion IPR013740; IPR012336; Peroxiredoxin-2B (EC 1.11.1.15) (Peroxiredoxin IIB) (Peroxiredoxin TPx1) (Thioredoxin reductase 2B) (Thioredoxin-dependent peroxidase 1) PRXIIB TPX1 At1g65980 F12P19.14 Arabidopsis thaliana (Mouse-ear cress) TR38859_c4_g1_i11 P54106 ICLN_XENLA 1.00E-29 GO:0006884; GO:0006821; GO:0005737; GO:0005634 cell volume homeostasis; chloride transport; cytoplasm; nucleus IPR003521; Methylosome subunit pICln (Chloride conductance regulatory protein ICln) (I(Cln)) clns1a icln Xenopus laevis (African clawed frog) TR38859_c4_g1_i4 P54106 ICLN_XENLA 2.00E-29 GO:0006884; GO:0006821; GO:0005737; GO:0005634 cell volume homeostasis; chloride transport; cytoplasm; nucleus IPR003521; Methylosome subunit pICln (Chloride conductance regulatory protein ICln) (I(Cln)) clns1a icln Xenopus laevis (African clawed frog) TR38861_c0_g1_i1 P12672 RAPSN_MOUSE 4.00E-08 GO:0005794; GO:0030054; GO:0005856; GO:0031594; GO:0005886; GO:0043525; GO:0045211; GO:0007271; GO:0008270 "Golgi apparatus; cell junction; cytoskeleton; neuromuscular junction; plasma membrane; positive regulation of neuron apoptotic process; postsynaptic membrane; synaptic transmission, cholinergic; zinc ion binding" IPR001237; IPR018293; IPR019568; IPR013026; IPR011990; IPR001440; IPR019734; IPR001841; IPR013083; 43 kDa receptor-associated protein of the synapse (RAPsyn) (43 kDa postsynaptic protein) (Acetylcholine receptor-associated 43 kDa protein) Rapsn Mus musculus (Mouse) TR38861_c0_g1_i2 P81274 GPSM2_HUMAN 0 GO:0007186; GO:0005092; GO:0045177; GO:0005938; GO:0005737; GO:0000132; GO:0060487; GO:0005634; GO:0008277 Itself; P63096; Q14980 G-protein coupled receptor signaling pathway; GDP-dissociation inhibitor activity; apical part of cell; cell cortex; cytoplasm; establishment of mitotic spindle orientation; lung epithelial cell differentiation; nucleus; regulation of G-protein coupled receptor protein signaling pathway IPR024807; IPR003109; IPR013026; IPR011990; IPR001440; IPR019734; G-protein-signaling modulator 2 (Mosaic protein LGN) GPSM2 LGN Homo sapiens (Human) TR38861_c0_g1_i3 P81274 GPSM2_HUMAN 0 GO:0007186; GO:0005092; GO:0045177; GO:0005938; GO:0005737; GO:0000132; GO:0060487; GO:0005634; GO:0008277 Itself; P63096; Q14980 G-protein coupled receptor signaling pathway; GDP-dissociation inhibitor activity; apical part of cell; cell cortex; cytoplasm; establishment of mitotic spindle orientation; lung epithelial cell differentiation; nucleus; regulation of G-protein coupled receptor protein signaling pathway IPR024807; IPR003109; IPR013026; IPR011990; IPR001440; IPR019734; G-protein-signaling modulator 2 (Mosaic protein LGN) GPSM2 LGN Homo sapiens (Human) TR38861_c0_g1_i4 Q96AY4 TTC28_HUMAN 4.00E-47 GO:0051301; GO:0005737; GO:0005815; GO:0030496; GO:0007067; GO:0000922 cell division; cytoplasm; microtubule organizing center; midbody; mitosis; spindle pole IPR024983; IPR013026; IPR011990; IPR001440; IPR013105; IPR019734; Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) TTC28 KIAA1043 TPRBK Homo sapiens (Human) TR38861_c0_g4_i1 Q6GNT7 GOGA5_XENLA 2.00E-83 GO:0005794; GO:0000139; GO:0007030; GO:0048193; GO:0016021; GO:0042803 Golgi apparatus; Golgi membrane; Golgi organization; Golgi vesicle transport; integral to membrane; protein homodimerization activity IPR019177; Golgin subfamily A member 5 (Golgin-84) golga5 Xenopus laevis (African clawed frog) TR38863_c0_g2_i1 Q3AF07 DNAJ_CARHZ 1.00E-14 GO:0005524; GO:0006260; GO:0005737; GO:0006457; GO:0009408; GO:0008270 ATP binding; DNA replication; cytoplasm; protein folding; response to heat; zinc ion binding IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; Chaperone protein DnaJ dnaJ CHY_0416 Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) TR38863_c0_g2_i2 Q6MT07 DNAJ_MYCMS 6.00E-15 GO:0005524; GO:0006260; GO:0005737; GO:0006457; GO:0009408; GO:0008270 ATP binding; DNA replication; cytoplasm; protein folding; response to heat; zinc ion binding IPR012724; IPR002939; IPR001623; IPR008971; IPR001305; Chaperone protein DnaJ dnaJ MSC_0609 Mycoplasma mycoides subsp. mycoides SC (strain PG1) TR38863_c0_g2_i3 P71500 DNAJ_MYCCT 7.00E-14 GO:0005524; GO:0006260; GO:0005737; GO:0006457; GO:0009408; GO:0008270 ATP binding; DNA replication; cytoplasm; protein folding; response to heat; zinc ion binding IPR012724; IPR002939; IPR001623; IPR008971; IPR001305; Chaperone protein DnaJ dnaJ MCAP_0370 Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154) TR38864_c0_g1_i1 P97864 CASP7_MOUSE 4.00E-09 GO:0004190; GO:0097153; GO:0005737; GO:0097194; GO:0007507; GO:0005634; GO:0043525; GO:0016485; GO:0006508; GO:0001836; GO:0009411 P11103; P62270 aspartic-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cytoplasm; execution phase of apoptosis; heart development; nucleus; positive regulation of neuron apoptotic process; protein processing; proteolysis; release of cytochrome c from mitochondria; response to UV IPR015471; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; "Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11; Caspase-7, N-terminally processed]" Casp7 Lice2 Mch3 Mus musculus (Mouse) TR38864_c0_g1_i2 Q60431 CASP3_MESAU 1.00E-08 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 CPP32 Mesocricetus auratus (Golden hamster) TR38864_c0_g2_i2 O89094 CASPE_MOUSE 1.00E-13 GO:0006915; GO:0030154; GO:0004197; GO:0005737; GO:0005634; GO:0008233; GO:0006508 apoptotic process; cell differentiation; cysteine-type endopeptidase activity; cytoplasm; nucleus; peptidase activity; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-14 (CASP-14) (EC 3.4.22.-) (Mini-ICE) (MICE) [Cleaved into: Caspase-14 subunit p19; Caspase-14 subunit p10] Casp14 Mus musculus (Mouse) TR38864_c0_g2_i3 Q5IS99 CASP3_SAIBB 5.00E-35 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Saimiri boliviensis boliviensis (Bolivian squirrel monkey) TR38865_c5_g1_i4 Q00546 TENR_CHICK 2.00E-18 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR013032; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin-R (TN-R) (Restrictin) TNR Gallus gallus (Chicken) TR38865_c5_g1_i5 P33573 FIBA2_PETMA 7.00E-06 GO:0005577; GO:0030168; GO:0051258; GO:0007165 fibrinogen complex; platelet activation; protein polymerization; signal transduction IPR014716; IPR014715; IPR002181; IPR012290; IPR020837; Fibrinogen alpha-2 chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha-2 chain] Petromyzon marinus (Sea lamprey) TR38866_c0_g1_i1 Q8BP74 PSTK_MOUSE 2.00E-13 GO:0005524; GO:0016301; GO:0005739; GO:0001514; GO:0097056; GO:0000049 ATP binding; kinase activity; mitochondrion; selenocysteine incorporation; selenocysteinyl-tRNA(Sec) biosynthetic process; tRNA binding IPR013641; IPR020028; IPR027417; Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 1/2. L-seryl-tRNA(Sec) kinase (EC 2.7.1.164) (O-phosphoseryl-tRNA(Sec) kinase) Pstk Mus musculus (Mouse) TR38866_c0_g3_i6 Q8BP74 PSTK_MOUSE 3.00E-33 GO:0005524; GO:0016301; GO:0005739; GO:0001514; GO:0097056; GO:0000049 ATP binding; kinase activity; mitochondrion; selenocysteine incorporation; selenocysteinyl-tRNA(Sec) biosynthetic process; tRNA binding IPR013641; IPR020028; IPR027417; Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 1/2. L-seryl-tRNA(Sec) kinase (EC 2.7.1.164) (O-phosphoseryl-tRNA(Sec) kinase) Pstk Mus musculus (Mouse) TR38867_c2_g1_i1 Q8UVR5 BAZ1A_XENLA 2.00E-44 GO:0005634; GO:0006355; GO:0006351; GO:0008270 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001487; IPR018359; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Bromodomain adjacent to zinc finger domain protein 1A (ATP-utilizing chromatin assembly and remodeling factor 1) (xACF1) (Fragment) baz1a acf1 Xenopus laevis (African clawed frog) TR38867_c2_g1_i2 Q9NRL2 BAZ1A_HUMAN 3.00E-12 GO:0016590; GO:0008623; GO:0006261; GO:0006338; GO:0000228; GO:0006355; GO:0006351; GO:0008270 "ACF complex; CHRAC; DNA-dependent DNA replication; chromatin remodeling; nuclear chromosome; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001487; IPR018359; IPR004022; IPR018500; IPR018501; IPR013136; IPR019786; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) BAZ1A ACF1 WCRF180 HSPC317 Homo sapiens (Human) TR38869_c2_g3_i1 O46106 NOI_DROME 2.00E-46 GO:0005686; GO:0071013; GO:0009566; GO:0000398; GO:0007067; GO:0007052; GO:0003676; GO:0051533; GO:0071011; GO:0051726; GO:0008270 "U2 snRNP; catalytic step 2 spliceosome; fertilization; mRNA splicing, via spliceosome; mitosis; mitotic spindle organization; nucleic acid binding; positive regulation of NFAT protein import into nucleus; precatalytic spliceosome; regulation of cell cycle; zinc ion binding" IPR024598; IPR021966; IPR015880; IPR000690; Splicing factor 3A subunit 3 (Protein noisette) noi CG2925 Drosophila melanogaster (Fruit fly) TR38869_c3_g1_i1 Q9Z1Z0 USO1_MOUSE 0 GO:0000139; GO:0005829; GO:0006886; GO:0048471; GO:0008565; GO:0045056; GO:0048280 Golgi membrane; cytosol; intracellular protein transport; perinuclear region of cytoplasm; protein transporter activity; transcytosis; vesicle fusion with Golgi apparatus IPR011989; IPR016024; IPR000225; IPR006955; IPR024095; IPR006953; General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) Uso1 Vdp Mus musculus (Mouse) TR38869_c3_g1_i3 B0F9L4 GOGC6_ARATH 1.00E-58 GO:0000139; GO:0005795; GO:0005829; GO:0009791; GO:0032527; GO:0008565; GO:0048280 Golgi membrane; Golgi stack; cytosol; post-embryonic development; protein exit from endoplasmic reticulum; protein transporter activity; vesicle fusion with Golgi apparatus IPR016024; IPR006955; IPR024095; IPR006953; Golgin candidate 6 (AtGC6) GC6 At3g27530 MMJ24.8 MMJ24_7 Arabidopsis thaliana (Mouse-ear cress) TR38869_c3_g1_i4 Q9Z1Z0 USO1_MOUSE 0 GO:0000139; GO:0005829; GO:0006886; GO:0048471; GO:0008565; GO:0045056; GO:0048280 Golgi membrane; cytosol; intracellular protein transport; perinuclear region of cytoplasm; protein transporter activity; transcytosis; vesicle fusion with Golgi apparatus IPR011989; IPR016024; IPR000225; IPR006955; IPR024095; IPR006953; General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) Uso1 Vdp Mus musculus (Mouse) TR38869_c3_g1_i5 Q9Z1Z0 USO1_MOUSE 0 GO:0000139; GO:0005829; GO:0006886; GO:0048471; GO:0008565; GO:0045056; GO:0048280 Golgi membrane; cytosol; intracellular protein transport; perinuclear region of cytoplasm; protein transporter activity; transcytosis; vesicle fusion with Golgi apparatus IPR011989; IPR016024; IPR000225; IPR006955; IPR024095; IPR006953; General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) Uso1 Vdp Mus musculus (Mouse) TR38870_c1_g3_i1 Q43908 DDC_ACIBA 1.00E-40 GO:0019752; GO:0033983; GO:0030170 carboxylic acid metabolic process; diaminobutyrate decarboxylase activity; pyridoxal phosphate binding IPR002129; IPR015424; IPR015421; IPR015422; IPR021115; "Amine and polyamine biosynthesis; 1,3-diaminopropane biosynthesis; 1,3-diaminopropane from L-aspartate 4-semialdehyde: step 2/2." "L-2,4-diaminobutyrate decarboxylase (DABA decarboxylase) (DABA-DC) (EC 4.1.1.86)" ddc Acinetobacter baumannii TR38870_c1_g3_i2 Q9Y600 CSAD_HUMAN 0 GO:0034641; GO:0030170; GO:0004782; GO:0000098; GO:0042412 cellular nitrogen compound metabolic process; pyridoxal phosphate binding; sulfinoalanine decarboxylase activity; sulfur amino acid catabolic process; taurine biosynthetic process IPR002129; IPR015424; IPR015421; IPR015422; Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 2/2. Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase) CSAD CSD Homo sapiens (Human) TR38870_c1_g3_i4 P48861 DDC_MANSE 1.00E-30 GO:0004058; GO:0042423; GO:0006520; GO:0030170 aromatic-L-amino-acid decarboxylase activity; catecholamine biosynthetic process; cellular amino acid metabolic process; pyridoxal phosphate binding IPR010977; IPR002129; IPR015424; IPR015421; IPR015422; IPR021115; Aromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC) Ddc Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) TR38875_c0_g1_i1 Q16769 QPCT_HUMAN 2.00E-80 GO:0005576; GO:0016603; GO:0008233; GO:0017186; GO:0006508; GO:0008270 "extracellular region; glutaminyl-peptide cyclotransferase activity; peptidase activity; peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase; proteolysis; zinc ion binding" IPR007484; Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (QC) (sQC) (Glutaminyl-tRNA cyclotransferase) (Glutamyl cyclase) (EC) QPCT Homo sapiens (Human) TR38876_c6_g1_i2 Q6PDZ2 TAF1C_MOUSE 2.00E-19 GO:0003677; GO:0000120; GO:0006355; GO:0006360 "DNA binding; RNA polymerase I transcription factor complex; regulation of transcription, DNA-dependent; transcription from RNA polymerase I promoter" IPR015943; IPR017986; TATA box-binding protein-associated factor RNA polymerase I subunit C (RNA polymerase I-specific TBP-associated factor 95 kDa) (TAFI95) (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (Transcription initiation factor SL1/TIF-IB subunit C) Taf1c Mus musculus (Mouse) TR38876_c7_g4_i2 Q28FE4 MORN5_XENTR 5.00E-88 IPR003409; MORN repeat-containing protein 5 morn5 TEgg084k12.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38876_c7_g4_i3 P50584 AP4A_PIG 2.00E-40 GO:0005525; GO:0006915; GO:0004081; GO:0005739 GTP binding; apoptotic process; bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity; mitochondrion IPR020084; IPR000086; IPR015797; IPR003565; "Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] (EC 3.6.1.17) (Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase) (Ap4A hydrolase) (Ap4Aase) (Diadenosine tetraphosphatase) (Nucleoside diphosphate-linked moiety X motif 2) (Nudix motif 2)" NUDT2 APAH1 Sus scrofa (Pig) TR38876_c7_g4_i7 Q28FE4 MORN5_XENTR 4.00E-89 IPR003409; MORN repeat-containing protein 5 morn5 TEgg084k12.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38877_c0_g1_i6 Q5F457 WBP4_CHICK 9.00E-22 GO:0008380; GO:0006397; GO:0016607; GO:0003676; GO:0005681; GO:0008270 RNA splicing; mRNA processing; nuclear speck; nucleic acid binding; spliceosomal complex; zinc ion binding IPR001202; IPR000690; IPR003604; IPR013085; WW domain-binding protein 4 (WBP-4) WBP4 RCJMB04_3a20 Gallus gallus (Chicken) TR38879_c0_g3_i1 Q7T010 GATB_DANRE 9.00E-167 GO:0005524; GO:0016884; GO:0005739; GO:0006412 "ATP binding; carbon-nitrogen ligase activity, with glutamine as amido-N-donor; mitochondrion; translation" IPR004413; IPR017959; IPR006075; IPR018027; IPR003789; "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome c oxidase assembly factor PET112 homolog) (PET112-like)" pet112 pet112l si:ch211-150a22.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR38880_c1_g1_i1 Q5PQN9 RM38_RAT 2.00E-87 GO:0015629; GO:0005739; GO:0005840 actin cytoskeleton; mitochondrion; ribosome IPR008914; "39S ribosomal protein L38, mitochondrial (L38mt) (MRP-L38)" Mrpl38 Rattus norvegicus (Rat) TR38881_c0_g1_i1 P18537 FRIZ_DROME 2.00E-27 GO:0004930; GO:0007186; GO:0030165; GO:0007464; GO:0042813; GO:0017147; GO:0008356; GO:0008105; GO:0048675; GO:0007298; GO:0007420; GO:0060070; GO:0005938; GO:0009790; GO:0045198; GO:0008406; GO:0007507; GO:0007156; GO:0035320; GO:0005887; GO:0032589; GO:0016318; GO:0032231; GO:0035206; GO:0035159; GO:0007435; GO:0016360; GO:0001944 Q9V5N8 "G-protein coupled receptor activity; G-protein coupled receptor signaling pathway; PDZ domain binding; R3/R4 cell fate commitment; Wnt-activated receptor activity; Wnt-protein binding; asymmetric cell division; asymmetric protein localization; axon extension; border follicle cell migration; brain development; canonical Wnt receptor signaling pathway; cell cortex; embryo development; establishment of epithelial cell apical/basal polarity; gonad development; heart development; homophilic cell adhesion; imaginal disc-derived wing hair site selection; integral to plasma membrane; neuron projection membrane; ommatidial rotation; regulation of actin filament bundle assembly; regulation of hemocyte proliferation; regulation of tube length, open tracheal system; salivary gland morphogenesis; sensory organ precursor cell fate determination; vasculature development" IPR000539; IPR015526; IPR020067; IPR017981; Frizzled (Frizzled-1) (dFz1) fz CG17697 Drosophila melanogaster (Fruit fly) TR38881_c0_g1_i3 Q9NZR2 LRP1B_HUMAN 5.00E-32 GO:0005509; GO:0016021; GO:0005041; GO:0015031; GO:0006898 calcium ion binding; integral to membrane; low-density lipoprotein receptor activity; protein transport; receptor-mediated endocytosis IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) LRP1B LRPDIT Homo sapiens (Human) TR38881_c0_g1_i4 Q9NZR2 LRP1B_HUMAN 1.00E-23 GO:0005509; GO:0016021; GO:0005041; GO:0015031; GO:0006898 calcium ion binding; integral to membrane; low-density lipoprotein receptor activity; protein transport; receptor-mediated endocytosis IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) LRP1B LRPDIT Homo sapiens (Human) TR38883_c0_g2_i1 Q9VZW5 FMAR_DROME 2.00E-10 GO:0002209; GO:0007204; GO:0005887; GO:0008345; GO:0008188 behavioral defense response; elevation of cytosolic calcium ion concentration; integral to plasma membrane; larval locomotory behavior; neuropeptide receptor activity IPR000276; IPR017452; FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) TR38884_c2_g2_i2 Q6ZWJ8 KCP_HUMAN 3.00E-12 GO:0005576 extracellular region IPR002919; IPR014853; IPR001007; IPR001846; Kielin/chordin-like protein (Cysteine-rich BMP regulator 2) (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin/chordin-like protein 1) (KCP-1) KCP CRIM2 KCP1 Homo sapiens (Human) TR38885_c1_g1_i2 P35332 HPCL4_RAT 1.00E-19 GO:0005246; GO:0005509; GO:0005622 calcium channel regulator activity; calcium ion binding; intracellular IPR011992; IPR018247; IPR002048; IPR001125; Hippocalcin-like protein 4 (Neural visinin-like protein 2) (NVL-2) (NVP-2) (Visinin-like protein 2) (VILIP-2) Hpcal4 Rattus norvegicus (Rat) TR38886_c0_g3_i1 Q07890 SOS2_HUMAN 2.00E-165 GO:0003677; GO:0005089; GO:0097190; GO:0007411; GO:0005829; GO:0005085; GO:0048011; GO:0005543; GO:0043065; GO:0035023; GO:0051056; GO:0007264 P00519; P46108; P62993; P16333; Q9UKS6; P19174; Q9Y5X1 DNA binding; Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; axon guidance; cytosol; guanyl-nucleotide exchange factor activity; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR000219; IPR009072; IPR007125; IPR011993; IPR001849; IPR000651; IPR019804; IPR008937; IPR023578; IPR001895; Son of sevenless homolog 2 (SOS-2) SOS2 Homo sapiens (Human) TR38886_c0_g4_i1 Q07890 SOS2_HUMAN 9.00E-35 GO:0003677; GO:0005089; GO:0097190; GO:0007411; GO:0005829; GO:0005085; GO:0048011; GO:0005543; GO:0043065; GO:0035023; GO:0051056; GO:0007264 P00519; P46108; P62993; P16333; Q9UKS6; P19174; Q9Y5X1 DNA binding; Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; axon guidance; cytosol; guanyl-nucleotide exchange factor activity; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR000219; IPR009072; IPR007125; IPR011993; IPR001849; IPR000651; IPR019804; IPR008937; IPR023578; IPR001895; Son of sevenless homolog 2 (SOS-2) SOS2 Homo sapiens (Human) TR38886_c0_g6_i1 Q07889 SOS1_HUMAN 0 GO:0003677; GO:0038095; GO:0007265; GO:0005100; GO:0005089; GO:0097190; GO:0007411; GO:0005829; GO:0007173; GO:0008543; GO:0045087; GO:0008286; GO:0050900; GO:0048011; GO:0005543; GO:0005886; GO:0030168; GO:0043065 Q5TCZ1-2; P46108; P46109; P62993; P08631; P01112; P16333; P20929; Q9UKS6; P27986; P19174; P29353; Q9Y5X1 DNA binding; Fc-epsilon receptor signaling pathway; Ras protein signal transduction; Rho GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; axon guidance; cytosol; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; leukocyte migration; neurotrophin TRK receptor signaling pathway; phospholipid binding; plasma membrane; platelet activation; positive regulation of apoptotic process IPR000219; IPR009072; IPR007125; IPR011993; IPR001849; IPR000651; IPR019804; IPR008937; IPR023578; IPR001895; Son of sevenless homolog 1 (SOS-1) SOS1 Homo sapiens (Human) TR38886_c0_g6_i2 Q7TNR9 ARHG4_MOUSE 6.00E-13 GO:0030676; GO:0005737; GO:0046847; GO:0035556; GO:0030032; GO:0005543; GO:0035023 Rac guanyl-nucleotide exchange factor activity; cytoplasm; filopodium assembly; intracellular signal transduction; lamellipodium assembly; phospholipid binding; regulation of Rho protein signal transduction IPR000219; IPR001331; IPR011993; IPR001849; IPR001452; Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef) Arhgef4 Kiaa1112 Mus musculus (Mouse) TR38888_c0_g3_i1 P36582 PCK1_SCHPO 1.00E-118 GO:0005524; GO:0051519; GO:0032153; GO:0030428; GO:0005829; GO:0035556; GO:0046872; GO:0004697; GO:0008360; GO:0090334; GO:2000769 ATP binding; activation of bipolar cell growth; cell division site; cell septum; cytosol; intracellular signal transduction; metal ion binding; protein kinase C activity; regulation of cell shape; regulation of cell wall (1->3)-beta-D-glucan biosynthetic process; regulation of establishment or maintenance of cell polarity regulating cell shape IPR000961; IPR000008; IPR011072; IPR011009; IPR017892; IPR002219; IPR000719; IPR017441; IPR002290; IPR008271; Protein kinase C-like 1 (EC 2.7.11.13) pck1 SPAC17G8.14c SPAC22H10.01c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38888_c0_g3_i2 Q16975 KPC2_APLCA 0 GO:0005524; GO:0035556; GO:0016020; GO:0046872; GO:0004697 ATP binding; intracellular signal transduction; membrane; metal ion binding; protein kinase C activity IPR000961; IPR000008; IPR020454; IPR011009; IPR017892; IPR014376; IPR002219; IPR000719; IPR017441; IPR002290; IPR008271; Calcium-independent protein kinase C (EC 2.7.11.13) (APL II) PRKC2 Aplysia californica (California sea hare) TR38888_c0_g3_i3 Q16975 KPC2_APLCA 0 GO:0005524; GO:0035556; GO:0016020; GO:0046872; GO:0004697 ATP binding; intracellular signal transduction; membrane; metal ion binding; protein kinase C activity IPR000961; IPR000008; IPR020454; IPR011009; IPR017892; IPR014376; IPR002219; IPR000719; IPR017441; IPR002290; IPR008271; Calcium-independent protein kinase C (EC 2.7.11.13) (APL II) PRKC2 Aplysia californica (California sea hare) TR38888_c0_g5_i1 Q8TDF6 GRP4_HUMAN 1.00E-09 GO:0030742; GO:0005088; GO:0007202; GO:0005509; GO:0016049; GO:0008283; GO:0005737; GO:0019992; GO:0030099; GO:0005634; GO:0005886; GO:0046579; GO:0008277; GO:0009991; GO:0007264; GO:0007169 GTP-dependent protein binding; Ras guanyl-nucleotide exchange factor activity; activation of phospholipase C activity; calcium ion binding; cell growth; cell proliferation; cytoplasm; diacylglycerol binding; myeloid cell differentiation; nucleus; plasma membrane; positive regulation of Ras protein signal transduction; regulation of G-protein coupled receptor protein signaling pathway; response to extracellular stimulus; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway IPR020454; IPR002048; IPR002219; IPR000651; IPR008937; IPR023578; IPR001895; RAS guanyl-releasing protein 4 RASGRP4 Homo sapiens (Human) TR38889_c0_g1_i1 Q29496 CP3AO_SHEEP 2.00E-128 GO:0070330; GO:0005789; GO:0020037; GO:0005506; GO:0004497 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity IPR001128; IPR017972; IPR008072; IPR002402; Cytochrome P450 3A24 (EC 1.14.14.1) (CYPIIIA24) CYP3A24 Ovis aries (Sheep) TR38889_c0_g1_i2 Q64464 CP3AD_MOUSE 3.00E-123 GO:0070330; GO:0005789; GO:0020037; GO:0005506; GO:0004497; GO:0010628 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity; positive regulation of gene expression IPR001128; IPR017972; IPR008072; IPR002402; Cytochrome P450 3A13 (EC 1.14.14.1) (CYPIIIA13) Cyp3a13 Cyp3a-13 Mus musculus (Mouse) TR38889_c0_g1_i3 Q29496 CP3AO_SHEEP 6.00E-127 GO:0070330; GO:0005789; GO:0020037; GO:0005506; GO:0004497 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity IPR001128; IPR017972; IPR008072; IPR002402; Cytochrome P450 3A24 (EC 1.14.14.1) (CYPIIIA24) CYP3A24 Ovis aries (Sheep) TR38890_c0_g1_i2 P42748 UBC4_ARATH 2.00E-18 GO:0005524; GO:0006511; GO:0004842 ATP binding; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 4 (EC 6.3.2.19) (Ubiquitin carrier protein 4) (Ubiquitin-conjugating enzyme E2-21 kDa 1) (Ubiquitin-protein ligase 4) UBC4 At5g41340 MYC6.5 Arabidopsis thaliana (Mouse-ear cress) TR38890_c0_g1_i3 Q5R7J6 UBE2N_PONAB 2.00E-82 GO:0005524; GO:0000729; GO:0050852; GO:0031372; GO:0035370; GO:0000724; GO:0016574; GO:0005634; GO:0045739; GO:0043123; GO:0051092; GO:0031058; GO:0051443; GO:0006301; GO:0070534; GO:0033182; GO:0000151; GO:0006511; GO:0004842 ATP binding; DNA double-strand break processing; T cell receptor signaling pathway; UBC13-MMS2 complex; UBC13-UEV1A complex; double-strand break repair via homologous recombination; histone ubiquitination; nucleus; positive regulation of DNA repair; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of histone modification; positive regulation of ubiquitin-protein ligase activity; postreplication repair; protein K63-linked ubiquitination; regulation of histone ubiquitination; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 N (EC 6.3.2.19) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N) UBE2N Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38891_c0_g2_i1 Q66KD5 ING3_XENTR 7.00E-16 GO:0043968; GO:0043967; GO:0005634; GO:0043065; GO:0040008; GO:0006355; GO:0006351; GO:0008270 "histone H2A acetylation; histone H4 acetylation; nucleus; positive regulation of apoptotic process; regulation of growth; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR024610; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Inhibitor of growth protein 3 ing3 TNeu023p18.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38891_c1_g1_i2 Q5U208 THAP1_RAT 3.00E-08 GO:0016605; GO:0007049; GO:0001935; GO:0007346; GO:0006355; GO:0043565; GO:0006351; GO:0008270 "PML body; cell cycle; endothelial cell proliferation; regulation of mitotic cell cycle; regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription, DNA-dependent; zinc ion binding" IPR026516; IPR006612; THAP domain-containing protein 1 Thap1 Rattus norvegicus (Rat) TR38894_c0_g1_i1 Q5PQR5 IMP4_RAT 2.00E-137 GO:0005730; GO:0006364; GO:0030529 nucleolus; rRNA processing; ribonucleoprotein complex IPR004154; IPR007109; U3 small nucleolar ribonucleoprotein protein IMP4 (U3 snoRNP protein IMP4) Imp4 Rattus norvegicus (Rat) TR38894_c1_g1_i2 P48416 CP10_LYMST 9.00E-54 GO:0020037; GO:0005506; GO:0004497; GO:0016705 "heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Cytochrome P450 10 (EC 1.14.-.-) (CYPX) CYP10 Lymnaea stagnalis (Great pond snail) TR38896_c2_g1_i1 Q5TKA1 LIN9_HUMAN 0 GO:0006260; GO:0000278; GO:0005654; GO:0006351; GO:0017053 Q16254; P10244 "DNA replication; mitotic cell cycle; nucleoplasm; transcription, DNA-dependent; transcriptional repressor complex" IPR010561; Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein) LIN9 BARA TGS Homo sapiens (Human) TR38898_c3_g1_i1 A2AX52 CO6A4_MOUSE 9.00E-26 GO:0007155; GO:0005581; GO:0005576; GO:0043234; GO:0070208 cell adhesion; collagen; extracellular region; protein complex; protein heterotrimerization IPR008160; IPR002035; Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) TR38900_c0_g1_i1 P18754 RCC1_HUMAN 3.00E-142 GO:0000082; GO:0005087; GO:0051301; GO:0007059; GO:0000794; GO:0005737; GO:0042393; GO:0007067; GO:0007052; GO:0000790; GO:0031965; GO:0005654; GO:0031492; GO:0007088; GO:0051225; GO:0016032 P62826; Q9H6Z4 G1/S transition of mitotic cell cycle; Ran guanyl-nucleotide exchange factor activity; cell division; chromosome segregation; condensed nuclear chromosome; cytoplasm; histone binding; mitosis; mitotic spindle organization; nuclear chromatin; nuclear membrane; nucleoplasm; nucleosomal DNA binding; regulation of mitosis; spindle assembly; viral process IPR009091; IPR000408; Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) RCC1 CHC1 Homo sapiens (Human) TR38900_c0_g1_i2 P21827 RCC1_YEAST 1.00E-37 GO:0051301; GO:0005085; GO:0007067; GO:0000790; GO:0006407; GO:0019236; GO:0000054; GO:0004871 cell division; guanyl-nucleotide exchange factor activity; mitosis; nuclear chromatin; rRNA export from nucleus; response to pheromone; ribosomal subunit export from nucleus; signal transducer activity IPR009091; IPR000408; Guanine nucleotide exchange factor SRM1 (Pheromone response pathway component SRM1) (Pre-mRNA-processing protein 20) (Regulator of chromosome condensation) (Suppressor of receptor mutations 1) (mRNA transport protein 1) SRM1 MTR1 PRP20 YGL097W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR38902_c0_g1_i1 Q86Y13 DZIP3_HUMAN 2.00E-07 GO:0003723; GO:0005737; GO:0019902; GO:0031593; GO:0000209; GO:0004842; GO:0008270 Q9H0E2 RNA binding; cytoplasm; phosphatase binding; polyubiquitin binding; protein polyubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) TR38902_c0_g1_i6 Q7TPV2 DZIP3_MOUSE 1.00E-07 GO:0003723; GO:0005737; GO:0016874; GO:0019902; GO:0016567; GO:0008270 RNA binding; cytoplasm; ligase activity; phosphatase binding; protein ubiquitination; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog) Dzip3 Kiaa0675 Mus musculus (Mouse) TR38904_c2_g1_i1 Q5SQS7 SH24B_HUMAN 1.00E-39 IPR000980; SH2 domain-containing protein 4B SH2D4B Homo sapiens (Human) TR38904_c2_g1_i5 Q9H788 SH24A_HUMAN 4.00E-33 GO:0005737; GO:0010923; GO:0005634; GO:0019902 Q9UJU6; P43364; P62136; Q99961 cytoplasm; negative regulation of phosphatase activity; nucleus; phosphatase binding IPR000980; SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38) SH2D4A PPP1R38 SH2A Homo sapiens (Human) TR38904_c2_g1_i9 Q5SQS7 SH24B_HUMAN 8.00E-41 IPR000980; SH2 domain-containing protein 4B SH2D4B Homo sapiens (Human) TR38905_c0_g2_i1 Q8N0X4 CLYBL_HUMAN 1.00E-26 GO:0006725; GO:0008815; GO:0009346; GO:0046872; GO:0005739 cellular aromatic compound metabolic process; citrate (pro-3S)-lyase activity; citrate lyase complex; metal ion binding; mitochondrion IPR005000; IPR011206; IPR015813; "Citrate lyase subunit beta-like protein, mitochondrial (Citrate lyase beta-like) (EC 4.1.-.-)" CLYBL CLB Homo sapiens (Human) TR38905_c0_g2_i2 Q8N0X4 CLYBL_HUMAN 1.00E-91 GO:0006725; GO:0008815; GO:0009346; GO:0046872; GO:0005739 cellular aromatic compound metabolic process; citrate (pro-3S)-lyase activity; citrate lyase complex; metal ion binding; mitochondrion IPR005000; IPR011206; IPR015813; "Citrate lyase subunit beta-like protein, mitochondrial (Citrate lyase beta-like) (EC 4.1.-.-)" CLYBL CLB Homo sapiens (Human) TR38906_c1_g1_i1 Q8VEH3 ARL8A_MOUSE 1.00E-112 GO:0005525; GO:0051301; GO:0007059; GO:0031902; GO:0005765; GO:0030496; GO:0007067; GO:0007264; GO:0051233 GTP binding; cell division; chromosome segregation; late endosome membrane; lysosomal membrane; midbody; mitosis; small GTPase mediated signal transduction; spindle midzone IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 8A (ADP-ribosylation factor-like protein 10B) (Novel small G protein indispensable for equal chromosome segregation 2) Arl8a Arl10b Gie2 Mus musculus (Mouse) TR38906_c1_g1_i3 Q8VEH3 ARL8A_MOUSE 2.00E-112 GO:0005525; GO:0051301; GO:0007059; GO:0031902; GO:0005765; GO:0030496; GO:0007067; GO:0007264; GO:0051233 GTP binding; cell division; chromosome segregation; late endosome membrane; lysosomal membrane; midbody; mitosis; small GTPase mediated signal transduction; spindle midzone IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 8A (ADP-ribosylation factor-like protein 10B) (Novel small G protein indispensable for equal chromosome segregation 2) Arl8a Arl10b Gie2 Mus musculus (Mouse) TR38910_c1_g1_i1 Q9VN27 LIPT2_DROME 1.00E-52 GO:0016874; GO:0009107; GO:0033819; GO:0005739; GO:0016415; GO:0009249 ligase activity; lipoate biosynthetic process; lipoyl(octanoyl) transferase activity; mitochondrion; octanoyltransferase activity; protein lipoylation IPR004143; IPR000544; IPR020605; Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2. "Putative lipoyltransferase 2, mitochondrial (EC 2.3.1.181) (Lipoate-protein ligase B) (Lipoyl/octanoyl transferase) (Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase)" CG9804 Drosophila melanogaster (Fruit fly) TR38910_c1_g2_i1 Q29R99 LIPT2_DANRE 5.00E-73 GO:0006464; GO:0016874; GO:0009107; GO:0033819; GO:0005739; GO:0016415 cellular protein modification process; ligase activity; lipoate biosynthetic process; lipoyl(octanoyl) transferase activity; mitochondrion; octanoyltransferase activity IPR004143; IPR000544; IPR020605; Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2. "Putative lipoyltransferase 2, mitochondrial (EC 2.3.1.181) (Lipoate-protein ligase B) (Lipoyl/octanoyl transferase) (Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase)" lipt2 zgc:136925 Danio rerio (Zebrafish) (Brachydanio rerio) TR38910_c1_g3_i1 Q6KZK7 LIPB2_PICTO 9.00E-30 GO:0006464; GO:0005737; GO:0009107; GO:0033819; GO:0016415 cellular protein modification process; cytoplasm; lipoate biosynthetic process; lipoyl(octanoyl) transferase activity; octanoyltransferase activity IPR004143; IPR000544; IPR020605; Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2. Probable octanoyltransferase 2 (EC 2.3.1.181) (Lipoate-protein ligase B 2) (Lipoyl/octanoyl transferase 2) (Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase 2) lipB2 PTO1260 Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) TR38912_c2_g1_i1 Q5XKE0 MYPC2_MOUSE 5.00E-18 GO:0007155; GO:0005856; GO:0006936; GO:0032982; GO:0005200 cell adhesion; cytoskeleton; muscle contraction; myosin filament; structural constituent of cytoskeleton IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; "Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform)" Mybpc2 Mus musculus (Mouse) TR38912_c2_g1_i12 O35136 NCAM2_MOUSE 1.00E-08 GO:0031225; GO:0030424; GO:0007155; GO:0016021; GO:0005886 anchored to membrane; axon; cell adhesion; integral to membrane; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR009138; Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2) (Neural cell adhesion molecule RB-8) (R4B12) Ncam2 Ocam Rncam Mus musculus (Mouse) TR38912_c2_g1_i13 P22648 FAS2_SCHAM 4.00E-07 GO:0007155; GO:0030154; GO:0016021; GO:0007399 cell adhesion; cell differentiation; integral to membrane; nervous system development IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013151; IPR009138; Fasciclin-2 (Fasciclin II) (FAS II) FAS2 Schistocerca americana (American grasshopper) TR38912_c2_g1_i14 P97603 NEO1_RAT 5.00E-11 GO:0007155; GO:0016021; GO:0005886 cell adhesion; integral to membrane; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR010560; Neogenin (Fragment) Neo1 Ngn Rattus norvegicus (Rat) TR38912_c2_g1_i16 Q23551 UNC22_CAEEL 7.00E-28 GO:0031672; GO:0005524; GO:0046872; GO:0004674 A band; ATP binding; metal ion binding; protein serine/threonine kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans TR38912_c2_g1_i17 Q02173 MPSF_CHICK 2.00E-21 IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; "M-protein, striated muscle" Gallus gallus (Chicken) TR38912_c2_g1_i2 Q90Z04 CDON_XENLA 1.00E-07 GO:0007155; GO:0016021; GO:0005886 cell adhesion; integral to membrane; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; Cell adhesion molecule-related/down-regulated by oncogenes cdon cdo Xenopus laevis (African clawed frog) TR38912_c2_g1_i3 Q86VF2 IGFN1_HUMAN 7.00E-31 GO:0030018; GO:0005634 Z disc; nucleus IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Immunoglobulin-like and fibronectin type III domain-containing protein 1 (EEF1A2-binding protein 1) (KY-interacting protein 1) IGFN1 EEF1A2BP1 KYIP1 Homo sapiens (Human) TR38912_c2_g1_i4 P52179 MYOM1_HUMAN 7.00E-17 GO:0031430; GO:0006936; GO:0042803; GO:0005863; GO:0008307 Itself; O75923 M band; muscle contraction; protein homodimerization activity; striated muscle myosin thick filament; structural constituent of muscle IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) MYOM1 Homo sapiens (Human) TR38912_c2_g1_i5 Q53EP0 FND3B_HUMAN 3.00E-14 GO:0005783; GO:0016021; GO:0045600 endoplasmic reticulum; integral to membrane; positive regulation of fat cell differentiation IPR003961; IPR013783; Fibronectin type III domain-containing protein 3B (Factor for adipocyte differentiation 104) (HCV NS5A-binding protein 37) FNDC3B FAD104 NS5ABP37 UNQ2421/PRO4979/PRO34274 Homo sapiens (Human) TR38912_c2_g1_i6 Q02173 MPSF_CHICK 3.00E-36 IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; "M-protein, striated muscle" Gallus gallus (Chicken) TR38912_c2_g1_i7 Q15746 MYLK_HUMAN 5.00E-10 GO:0005524; GO:0060414; GO:0032060; GO:0071476; GO:0032154; GO:0005829; GO:0030027; GO:0046872; GO:0004687; GO:0005886; GO:0051928; GO:0030335; GO:0090303; GO:0001725; GO:0014820 P16333 ATP binding; aorta smooth muscle tissue morphogenesis; bleb assembly; cellular hypotonic response; cleavage furrow; cytosol; lamellipodium; metal ion binding; myosin light chain kinase activity; plasma membrane; positive regulation of calcium ion transport; positive regulation of cell migration; positive regulation of wound healing; stress fiber; tonic smooth muscle contraction IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR020675; IPR000719; IPR017441; IPR002290; IPR008271; "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]" MYLK MLCK MLCK1 MYLK1 Homo sapiens (Human) TR38912_c2_g1_i8 Q9I7U4 TITIN_DROME 6.00E-42 GO:0030018; GO:0003779; GO:0051301; GO:0000794; GO:0040011; GO:0007498; GO:0005875; GO:0007076; GO:0016203; GO:0007520; GO:0035206; GO:0045214; GO:0007062; GO:0007519; GO:0007525; GO:0008307; GO:0007522 Z disc; actin binding; cell division; condensed nuclear chromosome; locomotion; mesoderm development; microtubule associated complex; mitotic chromosome condensation; muscle attachment; myoblast fusion; regulation of hemocyte proliferation; sarcomere organization; sister chromatid cohesion; skeletal muscle tissue development; somatic muscle development; structural constituent of muscle; visceral muscle development IPR010939; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR001452; Titin (D-Titin) (Kettin) sls titin CG1915 Drosophila melanogaster (Fruit fly) TR38912_c2_g1_i9 Q8N9C0 IGS22_HUMAN 6.00E-16 IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; Immunoglobulin superfamily member 22 (IgSF22) IGSF22 Homo sapiens (Human) TR38912_c2_g2_i1 Q4KMG0 CDON_HUMAN 4.00E-08 GO:0009952; GO:0007155; GO:0001708; GO:0021987; GO:0010172; GO:0060059; GO:0016021; GO:0002088; GO:0042692; GO:0007520; GO:0005886; GO:0043410; GO:0051149; GO:2000179; GO:0045666; GO:0001934; GO:0048643; GO:0051057; GO:0045944; GO:0043497; GO:0014816; GO:0007224 P00519 anterior/posterior pattern specification; cell adhesion; cell fate specification; cerebral cortex development; embryonic body morphogenesis; embryonic retina morphogenesis in camera-type eye; integral to membrane; lens development in camera-type eye; muscle cell differentiation; myoblast fusion; plasma membrane; positive regulation of MAPK cascade; positive regulation of muscle cell differentiation; positive regulation of neural precursor cell proliferation; positive regulation of neuron differentiation; positive regulation of protein phosphorylation; positive regulation of skeletal muscle tissue development; positive regulation of small GTPase mediated signal transduction; positive regulation of transcription from RNA polymerase II promoter; regulation of protein heterodimerization activity; satellite cell differentiation; smoothened signaling pathway IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Cell adhesion molecule-related/down-regulated by oncogenes CDON CDO Homo sapiens (Human) TR38912_c2_g4_i1 A2RUH7 MBPHL_HUMAN 1.00E-06 IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Myosin-binding protein H-like MYBPHL Homo sapiens (Human) TR38913_c0_g2_i2 Q5JVF3 PCID2_HUMAN 0 GO:0043066; GO:2000117; GO:0045579; GO:0090267; GO:0045893; GO:0043488; GO:0048536 "negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity; positive regulation of B cell differentiation; positive regulation of mitotic cell cycle spindle assembly checkpoint; positive regulation of transcription, DNA-dependent; regulation of mRNA stability; spleen development" IPR013143; IPR000717; PCI domain-containing protein 2 (CSN12-like protein) PCID2 HT004 Homo sapiens (Human) TR38915_c2_g1_i1 A4IGK3 CRBL2_XENTR 9.00E-25 GO:0030154; GO:0005634; GO:0045600; GO:0046326; GO:0046889; GO:0045893; GO:0043565; GO:0003700; GO:0006351 "cell differentiation; nucleus; positive regulation of fat cell differentiation; positive regulation of glucose import; positive regulation of lipid biosynthetic process; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; cAMP-responsive element-binding protein-like 2 crebl2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38915_c2_g1_i9 A4IGK3 CRBL2_XENTR 1.00E-17 GO:0030154; GO:0005634; GO:0045600; GO:0046326; GO:0046889; GO:0045893; GO:0043565; GO:0003700; GO:0006351 "cell differentiation; nucleus; positive regulation of fat cell differentiation; positive regulation of glucose import; positive regulation of lipid biosynthetic process; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; cAMP-responsive element-binding protein-like 2 crebl2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38915_c2_g5_i1 P30038 AL4A1_HUMAN 0 GO:0003842; GO:0019470; GO:0004029; GO:0034641; GO:0009055; GO:0005759; GO:0006561; GO:0006562; GO:0010133 Itself 1-pyrroline-5-carboxylate dehydrogenase activity; 4-hydroxyproline catabolic process; aldehyde dehydrogenase (NAD) activity; cellular nitrogen compound metabolic process; electron carrier activity; mitochondrial matrix; proline biosynthetic process; proline catabolic process; proline catabolic process to glutamate IPR005931; IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2. "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase)" ALDH4A1 ALDH4 P5CDH Homo sapiens (Human) TR38915_c2_g5_i4 Q8UH56 BETB_AGRT5 1.00E-32 GO:0008802; GO:0019285; GO:0046872 betaine-aldehyde dehydrogenase activity; glycine betaine biosynthetic process from choline; metal ion binding IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR011264; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. NAD/NADP-dependent betaine aldehyde dehydrogenase (BADH) (EC 1.2.1.8) betB Atu0829 AGR_C_1515 Agrobacterium tumefaciens (strain C58 / ATCC 33970) TR38915_c2_g5_i6 P30038 AL4A1_HUMAN 0 GO:0003842; GO:0019470; GO:0004029; GO:0034641; GO:0009055; GO:0005759; GO:0006561; GO:0006562; GO:0010133 Itself 1-pyrroline-5-carboxylate dehydrogenase activity; 4-hydroxyproline catabolic process; aldehyde dehydrogenase (NAD) activity; cellular nitrogen compound metabolic process; electron carrier activity; mitochondrial matrix; proline biosynthetic process; proline catabolic process; proline catabolic process to glutamate IPR005931; IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2. "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase)" ALDH4A1 ALDH4 P5CDH Homo sapiens (Human) TR38917_c0_g2_i1 Q6ZNA5 FRRS1_HUMAN 9.00E-43 GO:0000293; GO:0016021; GO:0046872 ferric-chelate reductase activity; integral to membrane; metal ion binding IPR006593; IPR005018; IPR002861; Ferric-chelate reductase 1 (EC 1.-.-.-) (Stromal cell-derived receptor 2) (SDR-2) FRRS1 SDFR2 SDR2 Homo sapiens (Human) TR38917_c0_g2_i3 Q6INU7 FRRS1_XENLA 6.00E-38 GO:0016021; GO:0016491 integral to membrane; oxidoreductase activity IPR006593; IPR005018; IPR002861; Putative ferric-chelate reductase 1 (EC 1.-.-.-) frrs1 Xenopus laevis (African clawed frog) TR38918_c3_g1_i1 Q15262 PTPRK_HUMAN 3.00E-100 GO:0005912; GO:0030424; GO:0016477; GO:0009986; GO:0005911; GO:0034644; GO:0034614; GO:0030425; GO:0048041; GO:0005887; GO:0031256; GO:0045786; GO:0030336; GO:0010839; GO:0045892; GO:0043025; GO:0001750; GO:0034394; GO:0007179; GO:0005001 P04626; Q02763 "adherens junction; axon; cell migration; cell surface; cell-cell junction; cellular response to UV; cellular response to reactive oxygen species; dendrite; focal adhesion assembly; integral to plasma membrane; leading edge membrane; negative regulation of cell cycle; negative regulation of cell migration; negative regulation of keratinocyte proliferation; negative regulation of transcription, DNA-dependent; neuronal cell body; photoreceptor outer segment; protein localization to cell surface; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine phosphatase activity" IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) TR38918_c3_g1_i2 Q64487 PTPRD_MOUSE 1.00E-83 GO:0007157; GO:0016021; GO:0030182; GO:0035335; GO:0050775; GO:0097105; GO:0004725 P59823 heterophilic cell-cell adhesion; integral to membrane; neuron differentiation; peptidyl-tyrosine dephosphorylation; positive regulation of dendrite morphogenesis; presynaptic membrane assembly; protein tyrosine phosphatase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48) Ptprd Mus musculus (Mouse) TR38918_c3_g1_i3 Q15262 PTPRK_HUMAN 1.00E-104 GO:0005912; GO:0030424; GO:0016477; GO:0009986; GO:0005911; GO:0034644; GO:0034614; GO:0030425; GO:0048041; GO:0005887; GO:0031256; GO:0045786; GO:0030336; GO:0010839; GO:0045892; GO:0043025; GO:0001750; GO:0034394; GO:0007179; GO:0005001 P04626; Q02763 "adherens junction; axon; cell migration; cell surface; cell-cell junction; cellular response to UV; cellular response to reactive oxygen species; dendrite; focal adhesion assembly; integral to plasma membrane; leading edge membrane; negative regulation of cell cycle; negative regulation of cell migration; negative regulation of keratinocyte proliferation; negative regulation of transcription, DNA-dependent; neuronal cell body; photoreceptor outer segment; protein localization to cell surface; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine phosphatase activity" IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) TR38918_c3_g1_i4 Q98936 PTPRG_CHICK 2.00E-73 GO:0016021; GO:0035335; GO:0004725 integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR001148; IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48) PTPRG Gallus gallus (Chicken) TR38918_c3_g1_i5 P28827 PTPRM_HUMAN 4.00E-97 GO:0045296; GO:0005913; GO:0007156; GO:0005887; GO:0030027; GO:0016525; GO:0010596; GO:0001937; GO:0048471; GO:0045909; GO:0042493; GO:0010842; GO:0031290; GO:0005001 Itself; P09803 cadherin binding; cell-cell adherens junction; homophilic cell adhesion; integral to plasma membrane; lamellipodium; negative regulation of angiogenesis; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; perinuclear region of cytoplasm; positive regulation of vasodilation; response to drug; retina layer formation; retinal ganglion cell axon guidance; transmembrane receptor protein tyrosine phosphatase activity IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR013151; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) TR38918_c3_g1_i6 Q98936 PTPRG_CHICK 8.00E-41 GO:0016021; GO:0035335; GO:0004725 integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR001148; IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48) PTPRG Gallus gallus (Chicken) TR38918_c3_g1_i7 Q15262 PTPRK_HUMAN 3.00E-100 GO:0005912; GO:0030424; GO:0016477; GO:0009986; GO:0005911; GO:0034644; GO:0034614; GO:0030425; GO:0048041; GO:0005887; GO:0031256; GO:0045786; GO:0030336; GO:0010839; GO:0045892; GO:0043025; GO:0001750; GO:0034394; GO:0007179; GO:0005001 P04626; Q02763 "adherens junction; axon; cell migration; cell surface; cell-cell junction; cellular response to UV; cellular response to reactive oxygen species; dendrite; focal adhesion assembly; integral to plasma membrane; leading edge membrane; negative regulation of cell cycle; negative regulation of cell migration; negative regulation of keratinocyte proliferation; negative regulation of transcription, DNA-dependent; neuronal cell body; photoreceptor outer segment; protein localization to cell surface; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein tyrosine phosphatase activity" IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) TR38919_c0_g1_i1 Q9NQC3 RTN4_HUMAN 7.00E-48 GO:0001525; GO:0006915; GO:0007413; GO:0060317; GO:0042995; GO:0021801; GO:0071786; GO:0030176; GO:0030517; GO:0043025; GO:0048011; GO:0005635; GO:0005886; GO:0042981; GO:2000172; GO:0030334 Q8WXF7; O43639 angiogenesis; apoptotic process; axonal fasciculation; cardiac epithelial to mesenchymal transition; cell projection; cerebral cortex radial glia guided migration; endoplasmic reticulum tubular network organization; integral to endoplasmic reticulum membrane; negative regulation of axon extension; neuronal cell body; neurotrophin TRK receptor signaling pathway; nuclear envelope; plasma membrane; regulation of apoptotic process; regulation of branching morphogenesis of a nerve; regulation of cell migration IPR003388; Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) RTN4 KIAA0886 NOGO My043 SP1507 Homo sapiens (Human) TR38919_c0_g1_i2 Q9JK11 RTN4_RAT 1.00E-48 GO:0007568; GO:0007413; GO:0021801; GO:0030176; GO:0043209; GO:0030517; GO:0045665; GO:0070571; GO:0043005; GO:0043025; GO:0005635; GO:0021553; GO:0048709; GO:0005886; GO:0033603; GO:0045687; GO:0043234; GO:0032403; GO:0048679; GO:2000172; GO:0051930; GO:0014823 Q8WXF7; Q6PST4 aging; axonal fasciculation; cerebral cortex radial glia guided migration; integral to endoplasmic reticulum membrane; myelin sheath; negative regulation of axon extension; negative regulation of neuron differentiation; negative regulation of neuron projection regeneration; neuron projection; neuronal cell body; nuclear envelope; olfactory nerve development; oligodendrocyte differentiation; plasma membrane; positive regulation of dopamine secretion; positive regulation of glial cell differentiation; protein complex; protein complex binding; regulation of axon regeneration; regulation of branching morphogenesis of a nerve; regulation of sensory perception of pain; response to activity IPR003388; Reticulon-4 (Foocen) (Glut4 vesicle 20 kDa protein) (Neurite outgrowth inhibitor) (Nogo protein) Rtn4 Nogo Rattus norvegicus (Rat) TR38919_c0_g1_i3 Q9JK11 RTN4_RAT 1.00E-48 GO:0007568; GO:0007413; GO:0021801; GO:0030176; GO:0043209; GO:0030517; GO:0045665; GO:0070571; GO:0043005; GO:0043025; GO:0005635; GO:0021553; GO:0048709; GO:0005886; GO:0033603; GO:0045687; GO:0043234; GO:0032403; GO:0048679; GO:2000172; GO:0051930; GO:0014823 Q8WXF7; Q6PST4 aging; axonal fasciculation; cerebral cortex radial glia guided migration; integral to endoplasmic reticulum membrane; myelin sheath; negative regulation of axon extension; negative regulation of neuron differentiation; negative regulation of neuron projection regeneration; neuron projection; neuronal cell body; nuclear envelope; olfactory nerve development; oligodendrocyte differentiation; plasma membrane; positive regulation of dopamine secretion; positive regulation of glial cell differentiation; protein complex; protein complex binding; regulation of axon regeneration; regulation of branching morphogenesis of a nerve; regulation of sensory perception of pain; response to activity IPR003388; Reticulon-4 (Foocen) (Glut4 vesicle 20 kDa protein) (Neurite outgrowth inhibitor) (Nogo protein) Rtn4 Nogo Rattus norvegicus (Rat) TR38919_c0_g1_i4 Q9NQC3 RTN4_HUMAN 2.00E-48 GO:0001525; GO:0006915; GO:0007413; GO:0060317; GO:0042995; GO:0021801; GO:0071786; GO:0030176; GO:0030517; GO:0043025; GO:0048011; GO:0005635; GO:0005886; GO:0042981; GO:2000172; GO:0030334 Q8WXF7; O43639 angiogenesis; apoptotic process; axonal fasciculation; cardiac epithelial to mesenchymal transition; cell projection; cerebral cortex radial glia guided migration; endoplasmic reticulum tubular network organization; integral to endoplasmic reticulum membrane; negative regulation of axon extension; neuronal cell body; neurotrophin TRK receptor signaling pathway; nuclear envelope; plasma membrane; regulation of apoptotic process; regulation of branching morphogenesis of a nerve; regulation of cell migration IPR003388; Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) RTN4 KIAA0886 NOGO My043 SP1507 Homo sapiens (Human) TR38919_c0_g1_i7 Q9NQC3 RTN4_HUMAN 1.00E-49 GO:0001525; GO:0006915; GO:0007413; GO:0060317; GO:0042995; GO:0021801; GO:0071786; GO:0030176; GO:0030517; GO:0043025; GO:0048011; GO:0005635; GO:0005886; GO:0042981; GO:2000172; GO:0030334 Q8WXF7; O43639 angiogenesis; apoptotic process; axonal fasciculation; cardiac epithelial to mesenchymal transition; cell projection; cerebral cortex radial glia guided migration; endoplasmic reticulum tubular network organization; integral to endoplasmic reticulum membrane; negative regulation of axon extension; neuronal cell body; neurotrophin TRK receptor signaling pathway; nuclear envelope; plasma membrane; regulation of apoptotic process; regulation of branching morphogenesis of a nerve; regulation of cell migration IPR003388; Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) RTN4 KIAA0886 NOGO My043 SP1507 Homo sapiens (Human) TR38920_c1_g1_i1 O57321 EAA1_AMBTI 9.00E-69 GO:0016021; GO:0017153 integral to membrane; sodium:dicarboxylate symporter activity IPR001991; IPR018107; Excitatory amino acid transporter 1 (SEAAT1) SLC1A3 EAAT1 Ambystoma tigrinum (Eastern tiger salamander) TR38920_c1_g1_i2 P51906 EAA3_MOUSE 5.00E-68 GO:0070779; GO:0051938; GO:0016595; GO:0015501; GO:0016021; GO:0005886; GO:0051260; GO:0017153 P53702 D-aspartate import; L-glutamate import; glutamate binding; glutamate:sodium symporter activity; integral to membrane; plasma membrane; protein homooligomerization; sodium:dicarboxylate symporter activity IPR001991; IPR018107; Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1) Slc1a1 Eaac1 Eaat3 Mus musculus (Mouse) TR38920_c1_g1_i3 P43006 EAA2_MOUSE 2.00E-71 GO:0070779; GO:0051938; GO:0030534; GO:0030673; GO:0031668; GO:0015501; GO:0005887; GO:0035264; GO:0010259; GO:0046326; GO:0043200; GO:0042493; GO:0009611; GO:0017153; GO:0021537; GO:0007632 D-aspartate import; L-glutamate import; adult behavior; axolemma; cellular response to extracellular stimulus; glutamate:sodium symporter activity; integral to plasma membrane; multicellular organism growth; multicellular organismal aging; positive regulation of glucose import; response to amino acid stimulus; response to drug; response to wounding; sodium:dicarboxylate symporter activity; telencephalon development; visual behavior IPR001991; IPR018107; Excitatory amino acid transporter 2 (GLT-1) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2) Slc1a2 Eaat2 Glt1 Mus musculus (Mouse) TR38921_c0_g1_i1 Q5FVF1 F10C1_RAT 4.00E-33 GO:0005634 nucleus IPR019129; Protein FRA10AC1 homolog Fra10ac1 Rattus norvegicus (Rat) TR38921_c0_g1_i4 Q8BP78 F10C1_MOUSE 3.00E-86 GO:0005634 nucleus IPR019129; Protein FRA10AC1 homolog Fra10ac1 Mus musculus (Mouse) TR38921_c0_g2_i1 Q9Y3B2 EXOS1_HUMAN 2.00E-75 GO:0003723; GO:0005829; GO:0043928; GO:0000178; GO:0010467; GO:0005730; GO:0006364 Q9NPD3; Q9NQT4; Q15024 RNA binding; cytosol; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; exosome (RNase complex); gene expression; nucleolus; rRNA processing IPR019495; IPR025721; IPR012340; IPR022967; Exosome complex component CSL4 (Exosome component 1) EXOSC1 CSL4 CGI-108 Homo sapiens (Human) TR38922_c0_g1_i1 Q755I4 GYP5_ASHGO 7.00E-21 GO:0005097; GO:0005737; GO:0006887; GO:0032851; GO:0015031 Rab GTPase activator activity; cytoplasm; exocytosis; positive regulation of Rab GTPase activity; protein transport IPR000195; GTPase-activating protein GYP5 GYP5 AFL161C Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR38922_c0_g1_i3 Q9P2M4 TBC14_HUMAN 6.00E-156 GO:0005794; GO:0005097; GO:0005776; GO:0010507; GO:0032851; GO:2000785 Q15907; O75385 Golgi apparatus; Rab GTPase activator activity; autophagic vacuole; negative regulation of autophagy; positive regulation of Rab GTPase activity; regulation of autophagic vacuole assembly IPR000195; TBC1 domain family member 14 TBC1D14 KIAA1322 Homo sapiens (Human) TR38922_c0_g1_i5 Q8CGA2 TBC14_MOUSE 1.00E-84 GO:0005794; GO:0005097; GO:0032851 Golgi apparatus; Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; TBC1 domain family member 14 Tbc1d14 D5Ertd110e Kiaa1322 Mus musculus (Mouse) TR38924_c1_g1_i2 Q96MM6 HS12B_HUMAN 7.00E-43 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR38924_c2_g3_i1 Q5HV33 DNAK_CAMJR 1.00E-09 GO:0005524; GO:0006457; GO:0009408 ATP binding; protein folding; response to heat IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK CJE0850 Campylobacter jejuni (strain RM1221) TR38924_c2_g3_i2 P30721 DNAK_CLOAB 6.00E-07 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK CA_C1282 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) TR38924_c2_g3_i3 Q8K0U4 HS12A_MOUSE 3.00E-15 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR38925_c0_g1_i3 Q5F3R7 DCA12_CHICK 8.00E-95 GO:0080008; GO:0005737; GO:0005815; GO:0016567 Cul4-RING ubiquitin ligase complex; cytoplasm; microtubule organizing center; protein ubiquitination IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 12 (WD repeat-containing protein 40A) DCAF12 WDR40A RCJMB04_8j18 Gallus gallus (Chicken) TR38925_c0_g1_i5 Q08BB3 DCA12_DANRE 1.00E-85 GO:0080008; GO:0005737; GO:0005815; GO:0016567 Cul4-RING ubiquitin ligase complex; cytoplasm; microtubule organizing center; protein ubiquitination IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 12 (WD repeat-containing protein 40A) dcaf12 wdr40a zgc:154031 Danio rerio (Zebrafish) (Brachydanio rerio) TR38925_c0_g2_i1 Q4R3J7 DCA12_MACFA 9.00E-08 GO:0080008; GO:0005737; GO:0005815; GO:0016567 Cul4-RING ubiquitin ligase complex; cytoplasm; microtubule organizing center; protein ubiquitination IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 12 (WD repeat-containing protein 40A) DCAF12 WDR40A QtsA-16482 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38926_c0_g1_i1 P32018 COEA1_CHICK 5.00E-22 GO:0007155; GO:0005581 cell adhesion; collagen IPR008160; IPR008985; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XIV) chain (Undulin) COL14A1 Gallus gallus (Chicken) TR38926_c0_g1_i2 P51942 MATN1_MOUSE 5.00E-32 GO:0003429; GO:0005578; GO:0030500 growth plate cartilage chondrocyte morphogenesis; proteinaceous extracellular matrix; regulation of bone mineralization IPR000742; IPR013032; IPR019466; IPR002035; Cartilage matrix protein (Matrilin-1) Matn1 Cmp Crtm Mus musculus (Mouse) TR38926_c0_g1_i3 P21941 MATN1_HUMAN 3.00E-31 GO:0030198; GO:0005201; GO:0003429; GO:0006461; GO:0005578; GO:0030500 extracellular matrix organization; extracellular matrix structural constituent; growth plate cartilage chondrocyte morphogenesis; protein complex assembly; proteinaceous extracellular matrix; regulation of bone mineralization IPR000742; IPR013032; IPR019466; IPR002035; Cartilage matrix protein (Matrilin-1) MATN1 CMP CRTM Homo sapiens (Human) TR38927_c0_g1_i1 Q04903 FNTB_PEA 5.00E-28 GO:0046872; GO:0018343; GO:0004660; GO:0005965; GO:0042127 metal ion binding; protein farnesylation; protein farnesyltransferase activity; protein farnesyltransferase complex; regulation of cell proliferation IPR026872; IPR001330; IPR008930; Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) FTB Pisum sativum (Garden pea) TR38927_c0_g1_i2 P53611 PGTB2_HUMAN 0 GO:0004663; GO:0006464; GO:0046872; GO:0018344; GO:0007601 P10398 Rab geranylgeranyltransferase activity; cellular protein modification process; metal ion binding; protein geranylgeranylation; visual perception IPR001330; IPR026873; IPR008930; Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta) RABGGTB GGTB Homo sapiens (Human) TR38928_c2_g1_i1 P16333 NCK1_HUMAN 1.00E-39 GO:0038096; GO:0042110; GO:0050852; GO:0007015; GO:0007411; GO:0016477; GO:0008093; GO:0005829; GO:0005783; GO:0045087; GO:0030032; GO:0060548; GO:0005634; GO:0005886; GO:0042102; GO:0030838; GO:0045944; GO:0004860; GO:0030159; GO:0006417; GO:0051707; GO:0007172; GO:0012506 Q9H222; P00519; P42684; Q15109; O43918; O15085; Q9ULH1; Q96NS5; Q9UIF9; O60885; Q9ULD4; P13671; P20810; P20963; P07766; P30260; Q9NYQ7; Q13111; Q14008; P78357; P78329; P98082; Q14118; O14490; Q9P1A6; O95886; Q9Y2H0; Q92988; Q05193; Q8IZD9; Q9H1R2; Q9H8V3; P41970; P42566; O00254; Q9BQ89; P31994; P31995; O75369; O75593; O15117; Q9UBS5; Q99259; P10912; Q9NZM4; P15586; O43708; P10412; O43390; P47928; Q9H9L3; O60674; P35968; Q9UMN6; Q13094; Q9BY71; P27816; Q92918; Q9Y4K4; Q9NQ76; Q15746; Q8WX92; P43699; O60500; Q13177; Q13087; O75167; O00750; Q9UL42; Q9BXM0; P29074; P15918; Q13905; P20936; Q9UQ26; Q8TB24; P26373; P78345; P10301; Q96GP6; O75326; Q9NZV5; Q9UPX8; Q9BYB0; Q13796; Q9UHI7; O60721; Q9UMY4; Q15036; Q9Y5X2; Q07889; Q07890; P08047; Q96T58; Q9H5I1; O15056; O43493; P42167; Q15661; Q9ULW0; Q9BWF2; Q9HCM9; O00294; Q96RL7; O43516 Fc-gamma receptor signaling pathway involved in phagocytosis; T cell activation; T cell receptor signaling pathway; actin filament organization; axon guidance; cell migration; cytoskeletal adaptor activity; cytosol; endoplasmic reticulum; innate immune response; lamellipodium assembly; negative regulation of cell death; nucleus; plasma membrane; positive regulation of T cell proliferation; positive regulation of actin filament polymerization; positive regulation of transcription from RNA polymerase II promoter; protein kinase inhibitor activity; receptor signaling complex scaffold activity; regulation of translation; response to other organism; signal complex assembly; vesicle membrane IPR017304; IPR000980; IPR001452; Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1) (SH2/SH3 adaptor protein NCK-alpha) NCK1 NCK Homo sapiens (Human) TR38928_c2_g1_i2 O35413 SRBS2_RAT 4.00E-09 GO:0030425; GO:0046872; GO:0043025; GO:0048471; GO:0014069 dendrite; metal ion binding; neuronal cell body; perinuclear region of cytoplasm; postsynaptic density IPR000108; IPR001452; IPR003127; IPR007087; Sorbin and SH3 domain-containing protein 2 (Arg/Abl-interacting protein 2) (ArgBP2) (Neural ArgBP2) (nArgBP2) (Sorbin) Sorbs2 Argbp2 Rattus norvegicus (Rat) TR38928_c2_g2_i1 Q2TBV5 TF2H2_BOVIN 6.00E-157 GO:0000439; GO:0005675; GO:0006289; GO:0006468; GO:0006355; GO:0006366; GO:0008270 "core TFIIH complex; holo TFIIH complex; nucleotide-excision repair; protein phosphorylation; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter; zinc ion binding" IPR007198; IPR004595; IPR012170; IPR002035; IPR007087; IPR015880; General transcription factor IIH subunit 2 (General transcription factor IIH polypeptide 2) GTF2H2 Bos taurus (Bovine) TR38928_c2_g7_i1 Q24708 CSW_DROVI 9.00E-12 GO:0005737; GO:0035335; GO:0004725; GO:0007362; GO:0008293 cytoplasm; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; terminal region determination; torso signaling pathway IPR000980; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase corkscrew (EC 3.1.3.48) (Fragment) csw Drosophila virilis (Fruit fly) TR38931_c2_g1_i1 P23610 F8I2_HUMAN 1.00E-66 GO:0005634 nucleus IPR011990 Factor VIII intron 22 protein (CpG island protein) F8A1 F8A; F8A2 F8A; F8A3 F8A Homo sapiens (Human) TR38932_c0_g1_i1 P21129 P3_MOUSE 5.00E-18 GO:0008508; GO:0016021; GO:0032526 bile acid:sodium symporter activity; integral to membrane; response to retinoic acid IPR002657; P3 protein (Solute carrier family 10 member 3) Slc10a3 P3 Mus musculus (Mouse) TR38932_c0_g1_i3 P21129 P3_MOUSE 7.00E-18 GO:0008508; GO:0016021; GO:0032526 bile acid:sodium symporter activity; integral to membrane; response to retinoic acid IPR002657; P3 protein (Solute carrier family 10 member 3) Slc10a3 P3 Mus musculus (Mouse) TR38932_c0_g1_i6 P21129 P3_MOUSE 6.00E-18 GO:0008508; GO:0016021; GO:0032526 bile acid:sodium symporter activity; integral to membrane; response to retinoic acid IPR002657; P3 protein (Solute carrier family 10 member 3) Slc10a3 P3 Mus musculus (Mouse) TR38932_c0_g1_i9 P21129 P3_MOUSE 5.00E-18 GO:0008508; GO:0016021; GO:0032526 bile acid:sodium symporter activity; integral to membrane; response to retinoic acid IPR002657; P3 protein (Solute carrier family 10 member 3) Slc10a3 P3 Mus musculus (Mouse) TR38933_c1_g1_i2 Q6PDX6 RN220_MOUSE 9.00E-57 GO:0005737; GO:0051865; GO:0004842; GO:0008270 Q62141 cytoplasm; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase Rnf220 (EC 6.3.2.-) (RING finger protein 220) Rnf220 Mus musculus (Mouse) TR38934_c1_g5_i3 O00329 PK3CD_HUMAN 2.00E-68 GO:0016303; GO:0035005; GO:0005524; GO:0042113; GO:0035754; GO:0001782; GO:0050853; GO:0038095; GO:0010818; GO:0030217; GO:0050852; GO:0002250; GO:0001816; GO:0007173; GO:0008543; GO:0006954; GO:0045087; GO:0002551; GO:0043303; GO:0060374; GO:0035747; GO:0001779; GO:0048011; GO:0030593; GO:0072672; GO:0014065; GO:0005942; GO:0046934; GO:0005886; GO:0006468; GO:0002679; GO:0044281 P01112 "1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; B cell activation; B cell chemotaxis; B cell homeostasis; B cell receptor signaling pathway; Fc-epsilon receptor signaling pathway; T cell chemotaxis; T cell differentiation; T cell receptor signaling pathway; adaptive immune response; cytokine production; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; inflammatory response; innate immune response; mast cell chemotaxis; mast cell degranulation; mast cell differentiation; natural killer cell chemotaxis; natural killer cell differentiation; neurotrophin TRK receptor signaling pathway; neutrophil chemotaxis; neutrophil extravasation; phosphatidylinositol 3-kinase cascade; phosphatidylinositol 3-kinase complex; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; plasma membrane; protein phosphorylation; respiratory burst involved in defense response; small molecule metabolic process" IPR016024; IPR000008; IPR011009; IPR000403; IPR018936; IPR003113; IPR002420; IPR000341; IPR015433; IPR001263; Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis. "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)" PIK3CD Homo sapiens (Human) TR38934_c1_g6_i1 P54675 PI3K3_DICDI 4.00E-22 GO:0016303; GO:0035005; GO:0005524; GO:0006928; GO:0005942; GO:0048015; GO:0005886; GO:0009617 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; cellular component movement; phosphatidylinositol 3-kinase complex; phosphatidylinositol-mediated signaling; plasma membrane; response to bacterium IPR016024; IPR000008; IPR011009; IPR000403; IPR018936; IPR002420; IPR000341; IPR015433; IPR001263; Phosphatidylinositol 3-kinase 3 (PI3-kinase) (PI3K) (PtdIns-3-kinase) (EC 2.7.1.137) pikC pik3 DDB_G0275011 Dictyostelium discoideum (Slime mold) TR38934_c1_g6_i3 Q9Z1L0 PK3CB_RAT 4.00E-31 GO:0016303; GO:0035005; GO:0005524; GO:0006914; GO:0031526; GO:0007155; GO:0006897; GO:0005634; GO:0005942; GO:0046934; GO:0048015 "1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; autophagy; brush border membrane; cell adhesion; endocytosis; nucleus; phosphatidylinositol 3-kinase complex; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphatidylinositol-mediated signaling" IPR016024; IPR000008; IPR011009; IPR000403; IPR018936; IPR003113; IPR002420; IPR000341; IPR015433; IPR001263; Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis. "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta)" Pik3cb Rattus norvegicus (Rat) TR38935_c0_g1_i2 Q9UJX3 APC7_HUMAN 9.00E-126 GO:0005680; GO:0031145; GO:0051301; GO:0005829; GO:0007067; GO:0007094; GO:0051436; GO:0005654; GO:0051437; GO:0070979 anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; cytosol; mitosis; mitotic spindle assembly checkpoint; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; protein K11-linked ubiquitination IPR013026; IPR011990; IPR013105; IPR019734; Protein modification; protein ubiquitination. Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7) ANAPC7 APC7 Homo sapiens (Human) TR38935_c0_g2_i2 Q9UJX3 APC7_HUMAN 2.00E-40 GO:0005680; GO:0031145; GO:0051301; GO:0005829; GO:0007067; GO:0007094; GO:0051436; GO:0005654; GO:0051437; GO:0070979 anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; cytosol; mitosis; mitotic spindle assembly checkpoint; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; protein K11-linked ubiquitination IPR013026; IPR011990; IPR013105; IPR019734; Protein modification; protein ubiquitination. Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7) ANAPC7 APC7 Homo sapiens (Human) TR38935_c0_g2_i3 Q54D58 APC7_DICDI 2.00E-07 GO:0051301; GO:0007067; GO:0005634; GO:0016567 cell division; mitosis; nucleus; protein ubiquitination IPR013026; IPR011990; IPR019734; Protein modification; protein ubiquitination. Anaphase-promoting complex subunit 7 (APC7) anapc7 apc7 DDB_G0292470 Dictyostelium discoideum (Slime mold) TR38938_c0_g1_i1 Q9XAR0 NUOG_STRCO 5.00E-78 GO:0051537; GO:0051539; GO:0042773; GO:0008137; GO:0009055; GO:0016020; GO:0030151; GO:0048038 "2 iron, 2 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; ATP synthesis coupled electron transport; NADH dehydrogenase (ubiquinone) activity; electron carrier activity; membrane; molybdenum ion binding; quinone binding" IPR001041; IPR009010; IPR012675; IPR006657; IPR006656; IPR006963; IPR000283; IPR010228; IPR019574; NADH-quinone oxidoreductase subunit G (EC 1.6.99.5) (NADH dehydrogenase I subunit G) (NDH-1 subunit G) nuoG SCO4568 SCD16A.15c Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) TR38938_c0_g1_i3 Q66HF1 NDUS1_RAT 0 GO:0051537; GO:0051539; GO:0046034; GO:0042773; GO:0008137; GO:0008637; GO:0045333; GO:0009055; GO:0046872; GO:0005758; GO:0005747; GO:0072593; GO:0051881 "2 iron, 2 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; ATP metabolic process; ATP synthesis coupled electron transport; NADH dehydrogenase (ubiquinone) activity; apoptotic mitochondrial changes; cellular respiration; electron carrier activity; metal ion binding; mitochondrial intermembrane space; mitochondrial respiratory chain complex I; reactive oxygen species metabolic process; regulation of mitochondrial membrane potential" IPR001041; IPR012675; IPR006656; IPR000283; IPR010228; IPR019574; IPR015405; "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3)" Ndufs1 Rattus norvegicus (Rat) TR38938_c0_g1_i4 Q66HF1 NDUS1_RAT 0 GO:0051537; GO:0051539; GO:0046034; GO:0042773; GO:0008137; GO:0008637; GO:0045333; GO:0009055; GO:0046872; GO:0005758; GO:0005747; GO:0072593; GO:0051881 "2 iron, 2 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; ATP metabolic process; ATP synthesis coupled electron transport; NADH dehydrogenase (ubiquinone) activity; apoptotic mitochondrial changes; cellular respiration; electron carrier activity; metal ion binding; mitochondrial intermembrane space; mitochondrial respiratory chain complex I; reactive oxygen species metabolic process; regulation of mitochondrial membrane potential" IPR001041; IPR012675; IPR006656; IPR000283; IPR010228; IPR019574; IPR015405; "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3)" Ndufs1 Rattus norvegicus (Rat) TR38939_c4_g5_i1 O62640 PIAP_PIG 5.00E-28 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR38939_c4_g5_i3 A9ULZ2 BIR7B_XENLA 2.00E-14 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) TR38939_c4_g5_i4 Q6R7E2 IAP2_OSHVF 4.00E-17 IPR001370; Putative apoptosis inhibitor ORF87 ORF87 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) TR38939_c4_g5_i5 Q13075 BIRC1_HUMAN 3.00E-12 GO:0005524; GO:0016323; GO:0004869; GO:0005737; GO:0006954; GO:0045087; GO:0046872; GO:0043154; GO:0043524; GO:0007399; GO:0017111 ATP binding; basolateral plasma membrane; cysteine-type endopeptidase inhibitor activity; cytoplasm; inflammatory response; innate immune response; metal ion binding; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of neuron apoptotic process; nervous system development; nucleoside-triphosphatase activity IPR003593; IPR001370; IPR007111; IPR027417; Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein) NAIP BIRC1 Homo sapiens (Human) TR38939_c4_g6_i3 Q13489 BIRC3_HUMAN 2.00E-23 GO:0038061; GO:0035666; GO:0006915; GO:0007166; GO:0005829; GO:0045087; GO:0070266; GO:0043066; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0043123; GO:0039535; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0034138; GO:0034142; GO:0004842; GO:0008270 Q13546; O43353; Q9Y572; P57078; Q12933 NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; apoptotic process; cell surface receptor signaling pathway; cytosol; innate immune response; necroptosis; negative regulation of apoptotic process; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of RIG-I signaling pathway; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Apoptosis inhibitor 2) (API2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (IAP-1) (hIAP-1) (hIAP1) (RING finger protein 49) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 IAP1 MIHC RNF49 Homo sapiens (Human) TR38939_c4_g6_i4 O62640 PIAP_PIG 1.00E-23 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR38939_c4_g6_i5 Q60989 XIAP_MOUSE 1.00E-19 GO:0016055; GO:0005737; GO:0005829; GO:1990001; GO:0043066; GO:0043524; GO:0051402; GO:0005634; GO:0048471; GO:0043234; GO:0004842; GO:0008270 P53702; Q9JIY5 Wnt receptor signaling pathway; cytoplasm; cytosol; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of neuron apoptotic process; neuron apoptotic process; nucleus; perinuclear region of cytoplasm; protein complex; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (mIAP-3) (mIAP3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) Xiap Aipa Api3 Birc4 Miha Mus musculus (Mouse) TR38939_c5_g1_i1 Q60HF3 HPS1_MACFA 7.00E-20 IPR026053; Hermansky-Pudlak syndrome 1 protein homolog HPS1 QflA-21346 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38941_c2_g1_i2 Q5BIR5 SPB8_BOVIN 7.00E-54 GO:0005737; GO:0005829; GO:0005615; GO:0030162; GO:0004867 cytoplasm; cytosol; extracellular space; regulation of proteolysis; serine-type endopeptidase inhibitor activity IPR023795; IPR023796; IPR000215; Serpin B8 SERPINB8 Bos taurus (Bovine) TR38941_c2_g1_i6 Q5BIR5 SPB8_BOVIN 2.00E-73 GO:0005737; GO:0005829; GO:0005615; GO:0030162; GO:0004867 cytoplasm; cytosol; extracellular space; regulation of proteolysis; serine-type endopeptidase inhibitor activity IPR023795; IPR023796; IPR000215; Serpin B8 SERPINB8 Bos taurus (Bovine) TR38944_c1_g1_i1 Q6UX98 ZDH24_HUMAN 6.00E-33 GO:0016021; GO:0016746; GO:0008270 "integral to membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Probable palmitoyltransferase ZDHHC24 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 24) (DHHC-24) ZDHHC24 UNQ2528/PRO6027 Homo sapiens (Human) TR38944_c1_g1_i2 Q94C49 ZDH18_ARATH 2.00E-14 GO:0030659; GO:0016021; GO:0005886; GO:0016746; GO:0008270 "cytoplasmic vesicle membrane; integral to membrane; plasma membrane; transferase activity, transferring acyl groups; zinc ion binding" IPR001594; Probable protein S-acyltransferase 13 (EC 2.3.1.225) (Probable palmitoyltransferase At4g22750) (Zinc finger DHHC domain-containing protein At4g22750) PAT13 At4g22750 T12H17.140 T12H17.2 Arabidopsis thaliana (Mouse-ear cress) TR38945_c0_g2_i1 Q8JZL1 I17RD_MOUSE 9.00E-16 GO:0000139; GO:0016021; GO:0046872; GO:0005886 Golgi membrane; integral to membrane; metal ion binding; plasma membrane IPR013568; IPR007087; Interleukin-17 receptor D (IL-17 receptor D) (IL-17RD) (Interleukin-17 receptor-like protein) (Sef homolog) (mSef) Il17rd Il17rlm Sef Mus musculus (Mouse) TR38945_c3_g1_i1 Q5RDD2 PR38A_PONAB 3.00E-113 GO:0008380; GO:0006397; GO:0005681 RNA splicing; mRNA processing; spliceosomal complex IPR005037; IPR024767; Pre-mRNA-splicing factor 38A PRPF38A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38946_c0_g2_i1 Q55FI1 GABT_DICDI 6.00E-171 GO:0003867; GO:0032144; GO:0009448; GO:0005739; GO:0042803; GO:0030170 4-aminobutyrate transaminase activity; 4-aminobutyrate transaminase complex; gamma-aminobutyric acid metabolic process; mitochondrion; protein homodimerization activity; pyridoxal phosphate binding IPR004631; IPR005814; IPR015424; IPR015421; IPR015422; 4-aminobutyrate aminotransferase (EC 2.6.1.19) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) gabT DDB_G0268104 Dictyostelium discoideum (Slime mold) TR38946_c0_g2_i2 P80147 GABT_PIG 8.00E-178 GO:0047298; GO:0003867; GO:0032144; GO:0048148; GO:0005829; GO:0009450; GO:0005759; GO:0042135; GO:0042803; GO:0030170; GO:0032145 (S)-3-amino-2-methylpropionate transaminase activity; 4-aminobutyrate transaminase activity; 4-aminobutyrate transaminase complex; behavioral response to cocaine; cytosol; gamma-aminobutyric acid catabolic process; mitochondrial matrix; neurotransmitter catabolic process; protein homodimerization activity; pyridoxal phosphate binding; succinate-semialdehyde dehydrogenase binding IPR004631; IPR005814; IPR015424; IPR015421; IPR015422; "4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT)" ABAT GABAT Sus scrofa (Pig) TR38947_c1_g1_i1 Q15853 USF2_HUMAN 3.00E-74 GO:0000978; GO:0003705; GO:0003690; GO:0007595; GO:0019086; GO:0055088; GO:0005634; GO:0045944; GO:0000432; GO:0043565; GO:0003700; GO:0006351 "RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; double-stranded DNA binding; lactation; late viral mRNA transcription; lipid homeostasis; nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter by glucose; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR011598; Upstream stimulatory factor 2 (Class B basic helix-loop-helix protein 12) (bHLHb12) (FOS-interacting protein) (FIP) (Major late transcription factor 2) (Upstream transcription factor 2) USF2 BHLHB12 Homo sapiens (Human) TR38948_c0_g2_i1 Q9VMJ7 KDM5_DROME 2.00E-09 GO:0003677; GO:0070822; GO:0043992; GO:0034647; GO:0045475; GO:0007275; GO:0016706; GO:0045893; GO:0006351; GO:0008270 "DNA binding; Sin3-type complex; histone acetyltransferase activity (H3-K9 specific); histone demethylase activity (H3-trimethyl-K4 specific); locomotor rhythm; multicellular organismal development; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001606; IPR003347; IPR013637; IPR003349; IPR019786; IPR004198; IPR011011; IPR001965; IPR019787; IPR013083; Lysine-specific demethylase lid (EC 1.14.11.-) (Histone demethylase lid) (Jumonji/ARID domain-containing protein lid) (Protein little imaginal disks) (Retinoblastoma-binding protein 2 homolog) lid CG9088 Drosophila melanogaster (Fruit fly) TR38950_c0_g1_i1 Q80SX5 OTOP2_MOUSE 4.00E-28 GO:0016021 integral to membrane IPR004878; Otopetrin-2 Otop2 Mus musculus (Mouse) TR38951_c0_g2_i1 Q6AXS5 PAIRB_RAT 2.00E-15 GO:0005737; GO:0003730; GO:0005634; GO:0048471; GO:0005886; GO:0042981 cytoplasm; mRNA 3'-UTR binding; nucleus; perinuclear region of cytoplasm; plasma membrane; regulation of apoptotic process IPR006861; IPR027205; "Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA-binding protein 1) (PAI-RBP1) (RDA288) (SERPINE1 mRNA-binding protein 1) [Cleaved into: Plasminogen activator inhibitor 1 RNA-binding protein, N-terminally processed]" Serbp1 Pairbp1 Rda288 Rattus norvegicus (Rat) TR38953_c1_g1_i3 Q924N4 S12A6_MOUSE 7.00E-83 GO:0016323; GO:0071477; GO:0016021; GO:0006813; GO:0015379 Q9Z1W9 basolateral plasma membrane; cellular hypotonic salinity response; integral to membrane; potassium ion transport; potassium:chloride symporter activity IPR004841; IPR018491; IPR000076; IPR004842; Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) Slc12a6 Kcc3 Mus musculus (Mouse) TR38953_c3_g1_i1 P55017 S12A3_HUMAN 5.00E-54 GO:0016324; GO:0005829; GO:0005887; GO:0035725; GO:0015378 apical plasma membrane; cytosol; integral to plasma membrane; sodium ion transmembrane transport; sodium:chloride symporter activity IPR004841; IPR013612; IPR004842; IPR002948; Solute carrier family 12 member 3 (Na-Cl cotransporter) (NCC) (Na-Cl symporter) (Thiazide-sensitive sodium-chloride cotransporter) SLC12A3 TSC Homo sapiens (Human) TR38953_c3_g1_i2 Q63632 S12A4_RAT 0 GO:0016021; GO:0006813; GO:0015379 integral to membrane; potassium ion transport; potassium:chloride symporter activity IPR004841; IPR000622; IPR018491; IPR000076; IPR004842; Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (rKCC1) (Furosemide-sensitive K-Cl cotransporter) Slc12a4 Kcc1 Rattus norvegicus (Rat) TR38955_c3_g1_i1 Q5U4T3 RHG26_XENLA 2.00E-104 GO:0005096; GO:0005737; GO:0005856; GO:0005925; GO:0005543; GO:0043547; GO:0007165 GTPase activator activity; cytoplasm; cytoskeleton; focal adhesion; phospholipid binding; positive regulation of GTPase activity; signal transduction IPR011993; IPR001849; IPR008936; IPR000198; IPR001452; Rho GTPase-activating protein 26 (Rho-type GTPase-activating protein 26) arhgap26 Xenopus laevis (African clawed frog) TR38955_c3_g1_i3 Q9UKG1 DP13A_HUMAN 6.00E-09 GO:0006915; GO:0007049; GO:0008283; GO:0005829; GO:0031901; GO:0010008; GO:0008286; GO:0005634; GO:0005543; GO:0043065; GO:0090003; GO:0046324; GO:0012506 Itself; P35609; Q96A54; Q91VH1; Q86V24; Q03001; O75923; P00533; O15379; Q9UL25; P20339; Q8WXH0 apoptotic process; cell cycle; cell proliferation; cytosol; early endosome membrane; endosome membrane; insulin receptor signaling pathway; nucleus; phospholipid binding; positive regulation of apoptotic process; regulation of establishment of protein localization to plasma membrane; regulation of glucose import; vesicle membrane IPR027267; IPR011993; IPR001849; IPR006020; "DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1)" APPL1 APPL DIP13A KIAA1428 Homo sapiens (Human) TR38955_c3_g1_i4 Q6ZQ82 RHG26_MOUSE 0 GO:0005096; GO:0005737; GO:0005856; GO:0046847; GO:0005925; GO:0005543; GO:0043547; GO:0007165 GTPase activator activity; cytoplasm; cytoskeleton; filopodium assembly; focal adhesion; phospholipid binding; positive regulation of GTPase activity; signal transduction IPR013606; IPR011993; IPR001849; IPR008936; IPR000198; IPR001452; Rho GTPase-activating protein 26 (Rho-type GTPase-activating protein 26) Arhgap26 Kiaa0621 Mus musculus (Mouse) TR38956_c0_g1_i1 A7MB10 RRP5_BOVIN 2.00E-32 GO:0003723; GO:0006397; GO:0005730; GO:0006364 RNA binding; mRNA processing; nucleolus; rRNA processing IPR003107; IPR012340; IPR003029; IPR022967; IPR008847; IPR013026; IPR011990; Protein RRP5 homolog (Programmed cell death protein 11) PDCD11 Bos taurus (Bovine) TR38956_c0_g1_i2 Q14690 RRP5_HUMAN 1.00E-27 GO:0003723; GO:0005829; GO:0006397; GO:0005730; GO:0005634; GO:0006364 P19838 RNA binding; cytosol; mRNA processing; nucleolus; nucleus; rRNA processing IPR003107; IPR012340; IPR003029; IPR022967; IPR008847; IPR013026; IPR011990; Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) PDCD11 KIAA0185 Homo sapiens (Human) TR38956_c0_g3_i1 Q5U367 PLOD3_RAT 0 GO:0031418; GO:0070831; GO:0032870; GO:0030199; GO:0001886; GO:0048730; GO:0001701; GO:0005506; GO:0060425; GO:0021915; GO:0033823; GO:0008475; GO:0008104; GO:0030867; GO:0042311 L-ascorbic acid binding; basement membrane assembly; cellular response to hormone stimulus; collagen fibril organization; endothelial cell morphogenesis; epidermis morphogenesis; in utero embryonic development; iron ion binding; lung morphogenesis; neural tube development; procollagen glucosyltransferase activity; procollagen-lysine 5-dioxygenase activity; protein localization; rough endoplasmic reticulum membrane; vasodilation IPR005123; IPR006620; IPR001006; "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3)" Plod3 Rattus norvegicus (Rat) TR38956_c0_g5_i1 P74142 RS1B_SYNY3 9.00E-08 GO:0003723; GO:0005840; GO:0003735; GO:0006412 RNA binding; ribosome; structural constituent of ribosome; translation IPR012340; IPR003029; IPR000110; IPR022967; 30S ribosomal protein S1 homolog B rps1b slr1984 Synechocystis sp. (strain PCC 6803 / Kazusa) TR38958_c0_g1_i1 Q32L63 VTA1_BOVIN 2.00E-78 GO:0010008; GO:0015031 endosome membrane; protein transport IPR023175 Vacuolar protein sorting-associated protein VTA1 homolog VTA1 Bos taurus (Bovine) TR38959_c0_g2_i1 Q80X82 SYMPK_MOUSE 6.00E-153 GO:0007155; GO:0005737; GO:0005856; GO:0006378; GO:0005654; GO:0005886; GO:0035307; GO:0005923 cell adhesion; cytoplasm; cytoskeleton; mRNA polyadenylation; nucleoplasm; plasma membrane; positive regulation of protein dephosphorylation; tight junction IPR011989; IPR016024; IPR021850; IPR022075; Symplekin Sympk Mus musculus (Mouse) TR38959_c0_g3_i1 Q92797 SYMPK_HUMAN 0 GO:0007155; GO:0005737; GO:0005856; GO:0006378; GO:0005654; GO:0005886; GO:0035307; GO:0005923 Q9P2I0 cell adhesion; cytoplasm; cytoskeleton; mRNA polyadenylation; nucleoplasm; plasma membrane; positive regulation of protein dephosphorylation; tight junction IPR011989; IPR016024; IPR021850; IPR022075; Symplekin SYMPK SPK Homo sapiens (Human) TR38961_c3_g3_i1 Q9HBI6 CP4FB_HUMAN 3.00E-29 GO:0070330; GO:0005789; GO:0020037; GO:0006954; GO:0016021; GO:0005506; GO:0004497; GO:0044281; GO:0006805 aromatase activity; endoplasmic reticulum membrane; heme binding; inflammatory response; integral to membrane; iron ion binding; monooxygenase activity; small molecule metabolic process; xenobiotic metabolic process IPR001128; IPR017972; IPR002401; Cytochrome P450 4F11 (EC 1.14.14.1) (CYPIVF11) CYP4F11 Homo sapiens (Human) TR38961_c3_g4_i2 Q9SHG5 C72C1_ARATH 1.00E-07 GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705; GO:0040008 "heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; regulation of growth" IPR001128; IPR017972; IPR002401; Cytochrome P450 72C1 (EC 1.14.-.-) (Protein CHIBI 2) (Protein DWARFISH WITH LOW FERTILITY) (Protein SHRINK 1) (Protein SUPPRESSOR OF PHYB-4 PROTEIN 7) CYP72C1 CHI2 DLF SHK1 SOB7 At1g17060 F20D23.24 Arabidopsis thaliana (Mouse-ear cress) TR38961_c3_g4_i5 Q9SHG5 C72C1_ARATH 7.00E-10 GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705; GO:0040008 "heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; regulation of growth" IPR001128; IPR017972; IPR002401; Cytochrome P450 72C1 (EC 1.14.-.-) (Protein CHIBI 2) (Protein DWARFISH WITH LOW FERTILITY) (Protein SHRINK 1) (Protein SUPPRESSOR OF PHYB-4 PROTEIN 7) CYP72C1 CHI2 DLF SHK1 SOB7 At1g17060 F20D23.24 Arabidopsis thaliana (Mouse-ear cress) TR38961_c3_g5_i1 Q9VYY4 C4G15_DROME 4.00E-11 GO:0005789; GO:0020037; GO:0005506; GO:0004497; GO:0016705 "endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Cytochrome P450 4g15 (EC 1.14.-.-) (CYPIVG15) Cyp4g15 CG11715 Drosophila melanogaster (Fruit fly) TR38961_c3_g5_i3 O44221 CP4E5_DROMT 1.00E-10 GO:0020037; GO:0005506; GO:0005739; GO:0004497; GO:0016705 "heme binding; iron ion binding; mitochondrion; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; "Cytochrome P450 4e5, mitochondrial (EC 1.14.-.-) (CYPIVE5)" Cyp4e5 Drosophila mettleri (Fruit fly) TR38961_c3_g6_i1 Q9EP75 CP4FE_MOUSE 1.00E-47 GO:0052871; GO:0005789; GO:0020037; GO:0005506; GO:0036101; GO:0050051 alpha-tocopherol omega-hydroxylase activity; endoplasmic reticulum membrane; heme binding; iron ion binding; leukotriene B4 catabolic process; leukotriene-B4 20-monooxygenase activity IPR001128; IPR017972; IPR002401; Lipid metabolism; leukotriene B4 degradation. Leukotriene-B4 omega-hydroxylase 3 (EC 1.14.13.30) (Cyp4f-14) (Cytochrome P450 4F14) (Cytochrome P450-LTB-omega) (Leukotriene-B4 20-monooxygenase 3) Cyp4f14 Mus musculus (Mouse) TR38963_c0_g1_i1 Q5QQ53 XYLT_DROPS 9.00E-10 GO:0042732; GO:0000139; GO:0008375; GO:0030206; GO:0050650; GO:0005789; GO:0015012; GO:0016021; GO:0030158 D-xylose metabolic process; Golgi membrane; acetylglucosaminyltransferase activity; chondroitin sulfate biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process; endoplasmic reticulum membrane; heparan sulfate proteoglycan biosynthetic process; integral to membrane; protein xylosyltransferase activity IPR003406; IPR002889; IPR024448; Glycan metabolism; chondroitin sulfate biosynthesis. Glycan metabolism; heparan sulfate biosynthesis. Xylosyltransferase oxt (EC 2.4.2.26) (Peptide O-xylosyltransferase) oxt xt GA16815 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR38963_c0_g2_i3 P84675 PFM_CHAGB 1.00E-08 GO:0050832; GO:0031640 defense response to fungus; killing of cells of other organism IPR002889; IPR013994; Putative fungistatic metabolite CHGG_05463 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) TR38963_c0_g2_i4 A2BGL3 WSCD2_DANRE 6.00E-09 GO:0016021; GO:0008146 integral to membrane; sulfotransferase activity IPR027417; IPR000863; IPR002889; IPR013994; WSC domain-containing protein 2 wscd2 si:ch211-240b21.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR38965_c0_g2_i1 O81395 DRTS_MAIZE 2.00E-137 GO:0006231; GO:0004146; GO:0006545; GO:0006730; GO:0046654; GO:0004799 dTMP biosynthetic process; dihydrofolate reductase activity; glycine biosynthetic process; one-carbon metabolic process; tetrahydrofolate biosynthetic process; thymidylate synthase activity IPR024072; IPR012262; IPR017925; IPR001796; IPR023451; IPR000398; IPR020940; "Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1." Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)] DRTS Zea mays (Maize) TR38965_c0_g2_i2 P04818 TYSY_HUMAN 2.00E-152 GO:0006281; GO:0006260; GO:0007568; GO:0051216; GO:0007623; GO:0048037; GO:0005829; GO:0006231; GO:0006235; GO:0046078; GO:0009157; GO:0048589; GO:0008144; GO:0005542; GO:0019088; GO:0060574; GO:0003729; GO:0005743; GO:0005759; GO:0005730; GO:0005654; GO:0000166; GO:0031100; GO:0048015; GO:0005976; GO:0006206; GO:0046134; GO:0000083; GO:0034097; GO:0042493; GO:0045471; GO:0051593; GO:0051384; GO:0046683; GO:0032570; GO:0009636; GO:0033189; GO:0046653; GO:0004799; GO:0019860 DNA repair; DNA replication; aging; cartilage development; circadian rhythm; cofactor binding; cytosol; dTMP biosynthetic process; dTTP biosynthetic process; dUMP metabolic process; deoxyribonucleoside monophosphate biosynthetic process; developmental growth; drug binding; folic acid binding; immortalization of host cell by virus; intestinal epithelial cell maturation; mRNA binding; mitochondrial inner membrane; mitochondrial matrix; nucleolus; nucleoplasm; nucleotide binding; organ regeneration; phosphatidylinositol-mediated signaling; polysaccharide metabolic process; pyrimidine nucleobase metabolic process; pyrimidine nucleoside biosynthetic process; regulation of transcription involved in G1/S transition of mitotic cell cycle; response to cytokine stimulus; response to drug; response to ethanol; response to folic acid; response to glucocorticoid stimulus; response to organophosphorus; response to progesterone stimulus; response to toxic substance; response to vitamin A; tetrahydrofolate metabolic process; thymidylate synthase activity; uracil metabolic process IPR023451; IPR000398; IPR020940; Pyrimidine metabolism; dTTP biosynthesis. Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) TYMS TS OK/SW-cl.29 Homo sapiens (Human) TR38965_c0_g2_i4 O76511 TYSY_DROME 2.00E-136 GO:0006231; GO:0006235; GO:0022008; GO:0004799 dTMP biosynthetic process; dTTP biosynthetic process; neurogenesis; thymidylate synthase activity IPR023451; IPR000398; IPR020940; Pyrimidine metabolism; dTTP biosynthesis. Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) Ts CG3181 Drosophila melanogaster (Fruit fly) TR38965_c0_g2_i6 P45352 TYSY_RAT 1.00E-151 GO:0007568; GO:0051216; GO:0007623; GO:0048037; GO:0006231; GO:0006235; GO:0046078; GO:0048589; GO:0008144; GO:0005542; GO:0019088; GO:0060574; GO:0003729; GO:0005743; GO:0005759; GO:0005730; GO:0000166; GO:0031100; GO:0005976; GO:0042803; GO:0034097; GO:0042493; GO:0045471; GO:0051593; GO:0051384; GO:0046683; GO:0032570; GO:0009636; GO:0033189; GO:0046653; GO:0004799; GO:0019860 aging; cartilage development; circadian rhythm; cofactor binding; dTMP biosynthetic process; dTTP biosynthetic process; dUMP metabolic process; developmental growth; drug binding; folic acid binding; immortalization of host cell by virus; intestinal epithelial cell maturation; mRNA binding; mitochondrial inner membrane; mitochondrial matrix; nucleolus; nucleotide binding; organ regeneration; polysaccharide metabolic process; protein homodimerization activity; response to cytokine stimulus; response to drug; response to ethanol; response to folic acid; response to glucocorticoid stimulus; response to organophosphorus; response to progesterone stimulus; response to toxic substance; response to vitamin A; tetrahydrofolate metabolic process; thymidylate synthase activity; uracil metabolic process IPR023451; IPR000398; IPR020940; Pyrimidine metabolism; dTTP biosynthesis. Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) Tyms Rattus norvegicus (Rat) TR38967_c0_g1_i1 P62332 ARF6_RAT 2.00E-100 GO:0005525; GO:0005794; GO:0030036; GO:0006915; GO:0005938; GO:0030866; GO:0016358; GO:0005769; GO:0030139; GO:0090162; GO:0031527; GO:0001889; GO:0005886; GO:0030838; GO:0090004; GO:0034394; GO:0036010; GO:0015031; GO:0055038; GO:0035020; GO:0060998; GO:0051489; GO:0001726; GO:0031529; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; actin cytoskeleton organization; apoptotic process; cell cortex; cortical actin cytoskeleton organization; dendrite development; early endosome; endocytic vesicle; establishment of epithelial cell polarity; filopodium membrane; liver development; plasma membrane; positive regulation of actin filament polymerization; positive regulation of establishment of protein localization to plasma membrane; protein localization to cell surface; protein localization to endosome; protein transport; recycling endosome membrane; regulation of Rac protein signal transduction; regulation of dendritic spine development; regulation of filopodium assembly; ruffle; ruffle organization; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor 6 Arf6 Rattus norvegicus (Rat) TR38968_c3_g1_i1 Q29IL2 POMT2_DROPS 2.00E-82 GO:0004169; GO:0005783; GO:0005789; GO:0016021; GO:0030259; GO:0097502; GO:0007517; GO:0006493 dolichyl-phosphate-mannose-protein mannosyltransferase activity; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; lipid glycosylation; mannosylation; muscle organ development; protein O-linked glycosylation IPR027005; IPR003342; IPR016093; Protein modification; protein glycosylation. Protein O-mannosyl-transferase 2 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 2) (Protein twisted) tw GA11548 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR38968_c6_g1_i1 Q8INB9 AKT1_DROME 0 GO:0005524; GO:0006915; GO:0009986; GO:0008362; GO:0007623; GO:0005829; GO:0031104; GO:0007427; GO:0008286; GO:0035556; GO:0019915; GO:0060292; GO:0043066; GO:0045886; GO:0035091; GO:0005886; GO:0048680; GO:0030307; GO:0045793; GO:0040018; GO:0046622; GO:0004674; GO:0008360; GO:0050773; GO:0035206; GO:0042306; GO:0006979 "ATP binding; apoptotic process; cell surface; chitin-based embryonic cuticle biosynthetic process; circadian rhythm; cytosol; dendrite regeneration; epithelial cell migration, open tracheal system; insulin receptor signaling pathway; intracellular signal transduction; lipid storage; long term synaptic depression; negative regulation of apoptotic process; negative regulation of synaptic growth at neuromuscular junction; phosphatidylinositol binding; plasma membrane; positive regulation of axon regeneration; positive regulation of cell growth; positive regulation of cell size; positive regulation of multicellular organism growth; positive regulation of organ growth; protein serine/threonine kinase activity; regulation of cell shape; regulation of dendrite development; regulation of hemocyte proliferation; regulation of protein import into nucleus; response to oxidative stress" IPR000961; IPR011009; IPR011993; IPR017892; IPR001849; IPR000719; IPR017441; IPR002290; IPR008271; RAC serine/threonine-protein kinase (DAkt) (DRAC-PK) (Dakt1) (EC 2.7.11.1) (Akt) (Protein kinase B) (PKB) Akt1 CG4006 Drosophila melanogaster (Fruit fly) TR38968_c6_g1_i11 Q8INB9 AKT1_DROME 0 GO:0005524; GO:0006915; GO:0009986; GO:0008362; GO:0007623; GO:0005829; GO:0031104; GO:0007427; GO:0008286; GO:0035556; GO:0019915; GO:0060292; GO:0043066; GO:0045886; GO:0035091; GO:0005886; GO:0048680; GO:0030307; GO:0045793; GO:0040018; GO:0046622; GO:0004674; GO:0008360; GO:0050773; GO:0035206; GO:0042306; GO:0006979 "ATP binding; apoptotic process; cell surface; chitin-based embryonic cuticle biosynthetic process; circadian rhythm; cytosol; dendrite regeneration; epithelial cell migration, open tracheal system; insulin receptor signaling pathway; intracellular signal transduction; lipid storage; long term synaptic depression; negative regulation of apoptotic process; negative regulation of synaptic growth at neuromuscular junction; phosphatidylinositol binding; plasma membrane; positive regulation of axon regeneration; positive regulation of cell growth; positive regulation of cell size; positive regulation of multicellular organism growth; positive regulation of organ growth; protein serine/threonine kinase activity; regulation of cell shape; regulation of dendrite development; regulation of hemocyte proliferation; regulation of protein import into nucleus; response to oxidative stress" IPR000961; IPR011009; IPR011993; IPR017892; IPR001849; IPR000719; IPR017441; IPR002290; IPR008271; RAC serine/threonine-protein kinase (DAkt) (DRAC-PK) (Dakt1) (EC 2.7.11.1) (Akt) (Protein kinase B) (PKB) Akt1 CG4006 Drosophila melanogaster (Fruit fly) TR38968_c6_g1_i2 Q8INB9 AKT1_DROME 0 GO:0005524; GO:0006915; GO:0009986; GO:0008362; GO:0007623; GO:0005829; GO:0031104; GO:0007427; GO:0008286; GO:0035556; GO:0019915; GO:0060292; GO:0043066; GO:0045886; GO:0035091; GO:0005886; GO:0048680; GO:0030307; GO:0045793; GO:0040018; GO:0046622; GO:0004674; GO:0008360; GO:0050773; GO:0035206; GO:0042306; GO:0006979 "ATP binding; apoptotic process; cell surface; chitin-based embryonic cuticle biosynthetic process; circadian rhythm; cytosol; dendrite regeneration; epithelial cell migration, open tracheal system; insulin receptor signaling pathway; intracellular signal transduction; lipid storage; long term synaptic depression; negative regulation of apoptotic process; negative regulation of synaptic growth at neuromuscular junction; phosphatidylinositol binding; plasma membrane; positive regulation of axon regeneration; positive regulation of cell growth; positive regulation of cell size; positive regulation of multicellular organism growth; positive regulation of organ growth; protein serine/threonine kinase activity; regulation of cell shape; regulation of dendrite development; regulation of hemocyte proliferation; regulation of protein import into nucleus; response to oxidative stress" IPR000961; IPR011009; IPR011993; IPR017892; IPR001849; IPR000719; IPR017441; IPR002290; IPR008271; RAC serine/threonine-protein kinase (DAkt) (DRAC-PK) (Dakt1) (EC 2.7.11.1) (Akt) (Protein kinase B) (PKB) Akt1 CG4006 Drosophila melanogaster (Fruit fly) TR38968_c6_g1_i3 Q01314 AKT1_BOVIN 0 GO:0005524; GO:0008643; GO:0005737; GO:0006006; GO:0005978; GO:0043154; GO:0090201; GO:0005634; GO:0005543; GO:0005886; GO:0004674; GO:0030334; GO:0010975; GO:0006417 Q9R269 ATP binding; carbohydrate transport; cytoplasm; glucose metabolic process; glycogen biosynthetic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of release of cytochrome c from mitochondria; nucleus; phospholipid binding; plasma membrane; protein serine/threonine kinase activity; regulation of cell migration; regulation of neuron projection development; regulation of translation IPR000961; IPR011009; IPR011993; IPR017892; IPR001849; IPR000719; IPR017441; IPR002290; IPR008271; RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (RAC-PK-alpha) AKT1 PKB Bos taurus (Bovine) TR38968_c6_g1_i5 P68180 KAPCB_CRIGR 2.00E-61 GO:0005524; GO:0004691; GO:0005737; GO:0000287; GO:0005634; GO:0005886 ATP binding; cAMP-dependent protein kinase activity; cytoplasm; magnesium ion binding; nucleus; plasma membrane IPR000961; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) PRKACB PKACB Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR38968_c6_g1_i6 Q17941 AKT1_CAEEL 8.00E-160 GO:0005524; GO:0005516; GO:0008340; GO:0045087; GO:0008286; GO:0005622; GO:0046872; GO:0005543; GO:0004674 Q9XTG7; O16850; G5EFM0; O18178; Q2PJ68 ATP binding; calmodulin binding; determination of adult lifespan; innate immune response; insulin receptor signaling pathway; intracellular; metal ion binding; phospholipid binding; protein serine/threonine kinase activity IPR000961; IPR011009; IPR011993; IPR017892; IPR001849; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase akt-1 (EC 2.7.11.1) (Protein kinase B akt-1) (PKB akt-1) akt-1 C12D8.10 Caenorhabditis elegans TR38968_c6_g1_i7 Q8INB9 AKT1_DROME 0 GO:0005524; GO:0006915; GO:0009986; GO:0008362; GO:0007623; GO:0005829; GO:0031104; GO:0007427; GO:0008286; GO:0035556; GO:0019915; GO:0060292; GO:0043066; GO:0045886; GO:0035091; GO:0005886; GO:0048680; GO:0030307; GO:0045793; GO:0040018; GO:0046622; GO:0004674; GO:0008360; GO:0050773; GO:0035206; GO:0042306; GO:0006979 "ATP binding; apoptotic process; cell surface; chitin-based embryonic cuticle biosynthetic process; circadian rhythm; cytosol; dendrite regeneration; epithelial cell migration, open tracheal system; insulin receptor signaling pathway; intracellular signal transduction; lipid storage; long term synaptic depression; negative regulation of apoptotic process; negative regulation of synaptic growth at neuromuscular junction; phosphatidylinositol binding; plasma membrane; positive regulation of axon regeneration; positive regulation of cell growth; positive regulation of cell size; positive regulation of multicellular organism growth; positive regulation of organ growth; protein serine/threonine kinase activity; regulation of cell shape; regulation of dendrite development; regulation of hemocyte proliferation; regulation of protein import into nucleus; response to oxidative stress" IPR000961; IPR011009; IPR011993; IPR017892; IPR001849; IPR000719; IPR017441; IPR002290; IPR008271; RAC serine/threonine-protein kinase (DAkt) (DRAC-PK) (Dakt1) (EC 2.7.11.1) (Akt) (Protein kinase B) (PKB) Akt1 CG4006 Drosophila melanogaster (Fruit fly) TR38968_c6_g1_i8 Q17941 AKT1_CAEEL 2.00E-164 GO:0005524; GO:0005516; GO:0008340; GO:0045087; GO:0008286; GO:0005622; GO:0046872; GO:0005543; GO:0004674 Q9XTG7; O16850; G5EFM0; O18178; Q2PJ68 ATP binding; calmodulin binding; determination of adult lifespan; innate immune response; insulin receptor signaling pathway; intracellular; metal ion binding; phospholipid binding; protein serine/threonine kinase activity IPR000961; IPR011009; IPR011993; IPR017892; IPR001849; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase akt-1 (EC 2.7.11.1) (Protein kinase B akt-1) (PKB akt-1) akt-1 C12D8.10 Caenorhabditis elegans TR38968_c6_g1_i9 Q5F3L1 KS6A5_CHICK 2.00E-58 GO:0005524; GO:0005737; GO:0043990; GO:0043987; GO:0043988; GO:0070498; GO:0007243; GO:0000287; GO:0045892; GO:0005634; GO:0051092; GO:0035066; GO:0033129; GO:0045944; GO:0004674; GO:0009605; GO:0006950 "ATP binding; cytoplasm; histone H2A-S1 phosphorylation; histone H3-S10 phosphorylation; histone H3-S28 phosphorylation; interleukin-1-mediated signaling pathway; intracellular protein kinase cascade; magnesium ion binding; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of histone acetylation; positive regulation of histone phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein serine/threonine kinase activity; response to external stimulus; response to stress" IPR000961; IPR011009; IPR017892; IPR000719; IPR017441; IPR016239; IPR002290; IPR008271; Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) RPS6KA5 RCJMB04_14g1 Gallus gallus (Chicken) TR38969_c3_g2_i1 Q9QZB7 ARP10_MOUSE 2.00E-58 GO:0005737; GO:0005869; GO:0007018 P42025 cytoplasm; dynactin complex; microtubule-based movement IPR004000; IPR027127; Actin-related protein 10 (Actin-related protein 11) Actr10 Act11 Actr11 Arp11 Mus musculus (Mouse) TR38969_c3_g2_i2 Q09443 ARP6_CAEEL 3.00E-07 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR004000; Actin-like protein C08B11.6 C08B11.6 Caenorhabditis elegans TR38969_c3_g3_i1 Q54JY2 ARP10_DICDI 9.00E-18 GO:0005737; GO:0005869; GO:0007018 cytoplasm; dynactin complex; microtubule-based movement IPR004000; IPR027127; Actin-related protein 10 (Actin-related protein 11) arpH actr10 actr11 arp10 arp11 DDB_G0287739 Dictyostelium discoideum (Slime mold) TR38969_c3_g3_i2 Q3ZBD2 ARP10_BOVIN 8.00E-60 GO:0005737; GO:0005869; GO:0007018 cytoplasm; dynactin complex; microtubule-based movement IPR004000; IPR027127; Actin-related protein 10 ACTR10 Bos taurus (Bovine) TR38971_c3_g1_i1 Q5RAD5 RTF1_PONAB 1.00E-100 GO:0016593; GO:0006352; GO:0016055; GO:0001711; GO:0016570; GO:0000122; GO:0032968; GO:0045944; GO:0003697; GO:0019827 "Cdc73/Paf1 complex; DNA-dependent transcription, initiation; Wnt receptor signaling pathway; endodermal cell fate commitment; histone modification; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; single-stranded DNA binding; stem cell maintenance" IPR004343; IPR018144; RNA polymerase-associated protein RTF1 homolog (Fragment) RTF1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38971_c3_g1_i2 Q92541 RTF1_HUMAN 8.00E-120 GO:0016593; GO:0006352; GO:0016055; GO:0001711; GO:0080182; GO:0000122; GO:0005730; GO:0051571; GO:0032968; GO:0045944; GO:0003697; GO:0019827 Q6P1J9; Q8N7H5 "Cdc73/Paf1 complex; DNA-dependent transcription, initiation; Wnt receptor signaling pathway; endodermal cell fate commitment; histone H3-K4 trimethylation; negative regulation of transcription from RNA polymerase II promoter; nucleolus; positive regulation of histone H3-K4 methylation; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; single-stranded DNA binding; stem cell maintenance" IPR004343; IPR018144; RNA polymerase-associated protein RTF1 homolog RTF1 KIAA0252 Homo sapiens (Human) TR38972_c6_g1_i1 Q6AZB8 HARB1_DANRE 8.00E-18 GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) TR38972_c7_g1_i5 Q8CFR0 C1QL2_MOUSE 1.00E-06 GO:0005581; GO:0005576; GO:0042802; GO:0051259 collagen; extracellular region; identical protein binding; protein oligomerization IPR001073; IPR008160; IPR008983; Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) (C1qTNF10) (CTRP10) C1ql2 C1qtnf10 Ctrp10 Mus musculus (Mouse) TR38972_c7_g3_i1 Q09324 GCNT1_MOUSE 5.00E-34 GO:0031985; GO:0000139; GO:0003829; GO:0060352; GO:0009101; GO:0016021; GO:0060993; GO:0050901; GO:0006486; GO:0048729 "Golgi cisterna; Golgi membrane; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; cell adhesion molecule production; glycoprotein biosynthetic process; integral to membrane; kidney morphogenesis; leukocyte tethering or rolling; protein glycosylation; tissue morphogenesis" IPR003406; Protein modification; protein glycosylation. "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (Core 2-branching enzyme) (Core2-GlcNAc-transferase) (C2GNT)" Gcnt1 Mus musculus (Mouse) TR38972_c7_g5_i1 Q06430 GNT2B_HUMAN 2.00E-33 GO:0000139; GO:0008109; GO:0006024; GO:0016021; GO:0016020; GO:0007275; GO:0006486 "Golgi membrane; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity; glycosaminoglycan biosynthetic process; integral to membrane; membrane; multicellular organismal development; protein glycosylation" IPR003406; Protein modification; protein glycosylation. "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform B (N-acetylglucosaminyltransferase) (EC 2.4.1.150) (I-branching enzyme) (IGNT)" GCNT2 GCNT5 II NACGT1 Homo sapiens (Human) TR38973_c4_g2_i4 Q95SX7 RTBS_DROME 7.00E-25 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR38975_c1_g1_i1 Q9C9G6 U195A_ARATH 3.00E-33 GO:0007059 chromosome segregation IPR002744; MIP18 family protein At1g68310 At1g68310 T22E19.6 Arabidopsis thaliana (Mouse-ear cress) TR38975_c1_g1_i3 Q9H5X1 FA96A_HUMAN 2.00E-39 GO:0007059; GO:0005737; GO:0046872 chromosome segregation; cytoplasm; metal ion binding IPR002744; MIP18 family protein FAM96A FAM96A Homo sapiens (Human) TR38976_c0_g2_i1 Q96JM2 ZN462_HUMAN 1.00E-07 GO:0003677; GO:0006325; GO:0046872; GO:0043392; GO:0005634; GO:0045944; GO:0006351 "DNA binding; chromatin organization; metal ion binding; negative regulation of DNA binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR007087; IPR015880; Zinc finger protein 462 ZNF462 KIAA1803 Homo sapiens (Human) TR38977_c0_g1_i2 Q9Y5X2 SNX8_HUMAN 2.00E-129 GO:0007154; GO:0031901; GO:0034498; GO:0006886; GO:0035091 Itself; P16333 cell communication; early endosome membrane; early endosome to Golgi transport; intracellular protein transport; phosphatidylinositol binding IPR001683; Sorting nexin-8 SNX8 Homo sapiens (Human) TR38977_c0_g1_i3 Q9Y5X2 SNX8_HUMAN 2.00E-129 GO:0007154; GO:0031901; GO:0034498; GO:0006886; GO:0035091 Itself; P16333 cell communication; early endosome membrane; early endosome to Golgi transport; intracellular protein transport; phosphatidylinositol binding IPR001683; Sorting nexin-8 SNX8 Homo sapiens (Human) TR38978_c1_g1_i2 P16331 PH4H_MOUSE 0 GO:0006559; GO:0016597; GO:0005506; GO:0004505 L-phenylalanine catabolic process; amino acid binding; iron ion binding; phenylalanine 4-monooxygenase activity IPR002912; IPR001273; IPR018301; IPR019774; IPR005961; IPR019773; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6. Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase) Pah Mus musculus (Mouse) TR38978_c1_g1_i3 P17276 PH4H_DROME 0 GO:0006559; GO:0005506; GO:0005811; GO:0007616; GO:0006909; GO:0004505; GO:0042427; GO:0004510 L-phenylalanine catabolic process; iron ion binding; lipid particle; long-term memory; phagocytosis; phenylalanine 4-monooxygenase activity; serotonin biosynthetic process; tryptophan 5-monooxygenase activity IPR001273; IPR018301; IPR019774; IPR005961; IPR019773; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6. Protein henna (EC 1.14.16.1) (EC 1.14.16.4) (Phe-4-monooxygenase) (Phenylalanine-4-hydroxylase) (PAH) (Tryptophan 5-hydroxylase) (TRH) (Tryptophan 5-monooxygenase) Hn pah Tph CG7399 Drosophila melanogaster (Fruit fly) TR38978_c1_g1_i5 P16331 PH4H_MOUSE 0 GO:0006559; GO:0016597; GO:0005506; GO:0004505 L-phenylalanine catabolic process; amino acid binding; iron ion binding; phenylalanine 4-monooxygenase activity IPR002912; IPR001273; IPR018301; IPR019774; IPR005961; IPR019773; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6. Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase) Pah Mus musculus (Mouse) TR38978_c1_g1_i7 P17276 PH4H_DROME 0 GO:0006559; GO:0005506; GO:0005811; GO:0007616; GO:0006909; GO:0004505; GO:0042427; GO:0004510 L-phenylalanine catabolic process; iron ion binding; lipid particle; long-term memory; phagocytosis; phenylalanine 4-monooxygenase activity; serotonin biosynthetic process; tryptophan 5-monooxygenase activity IPR001273; IPR018301; IPR019774; IPR005961; IPR019773; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6. Protein henna (EC 1.14.16.1) (EC 1.14.16.4) (Phe-4-monooxygenase) (Phenylalanine-4-hydroxylase) (PAH) (Tryptophan 5-hydroxylase) (TRH) (Tryptophan 5-monooxygenase) Hn pah Tph CG7399 Drosophila melanogaster (Fruit fly) TR38978_c1_g1_i8 P17276 PH4H_DROME 0 GO:0006559; GO:0005506; GO:0005811; GO:0007616; GO:0006909; GO:0004505; GO:0042427; GO:0004510 L-phenylalanine catabolic process; iron ion binding; lipid particle; long-term memory; phagocytosis; phenylalanine 4-monooxygenase activity; serotonin biosynthetic process; tryptophan 5-monooxygenase activity IPR001273; IPR018301; IPR019774; IPR005961; IPR019773; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6. Protein henna (EC 1.14.16.1) (EC 1.14.16.4) (Phe-4-monooxygenase) (Phenylalanine-4-hydroxylase) (PAH) (Tryptophan 5-hydroxylase) (TRH) (Tryptophan 5-monooxygenase) Hn pah Tph CG7399 Drosophila melanogaster (Fruit fly) TR38981_c1_g1_i1 P25067 CO8A2_HUMAN 1.00E-08 GO:0001525; GO:0005604; GO:0048593; GO:0016337; GO:0005581; GO:0030574; GO:0005788; GO:0050673; GO:0022617; GO:0005201; GO:0030674 "angiogenesis; basement membrane; camera-type eye morphogenesis; cell-cell adhesion; collagen; collagen catabolic process; endoplasmic reticulum lumen; epithelial cell proliferation; extracellular matrix disassembly; extracellular matrix structural constituent; protein binding, bridging" IPR001073; IPR008160; IPR008983; Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) TR38981_c2_g5_i1 Q8HXX2 MPI_MACFA 3.00E-131 GO:0009298; GO:0005975; GO:0005737; GO:0004476; GO:0008270 GDP-mannose biosynthetic process; carbohydrate metabolic process; cytoplasm; mannose-6-phosphate isomerase activity; zinc ion binding IPR001250; IPR016305; IPR018050; IPR014710; IPR011051; Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2. Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphohexomutase) (Phosphomannose isomerase) (PMI) MPI QccE-15018 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38981_c2_g5_i2 Q68FX1 MPI_RAT 4.00E-123 GO:0009298; GO:0005975; GO:0005737; GO:0004476; GO:0008270 GDP-mannose biosynthetic process; carbohydrate metabolic process; cytoplasm; mannose-6-phosphate isomerase activity; zinc ion binding IPR001250; IPR016305; IPR018050; IPR014710; IPR011051; Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2. Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphohexomutase) (Phosphomannose isomerase) (PMI) Mpi Rattus norvegicus (Rat) TR38981_c2_g5_i3 Q8HXX2 MPI_MACFA 8.00E-131 GO:0009298; GO:0005975; GO:0005737; GO:0004476; GO:0008270 GDP-mannose biosynthetic process; carbohydrate metabolic process; cytoplasm; mannose-6-phosphate isomerase activity; zinc ion binding IPR001250; IPR016305; IPR018050; IPR014710; IPR011051; Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2. Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphohexomutase) (Phosphomannose isomerase) (PMI) MPI QccE-15018 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38982_c1_g1_i1 P91685 GRM_DROME 0 GO:0015485; GO:0016595; GO:0001641; GO:0005887; GO:0045121; GO:0007528; GO:0051966 "cholesterol binding; glutamate binding; group II metabotropic glutamate receptor activity; integral to plasma membrane; membrane raft; neuromuscular junction development; regulation of synaptic transmission, glutamatergic" IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR000162; IPR028082; Metabotropic glutamate receptor (DmGluRA) mGluRA Glu-RA GluRA CG11144 Drosophila melanogaster (Fruit fly) TR38983_c0_g1_i1 Q495T6 MMEL1_HUMAN 4.00E-172 GO:0005794; GO:0005783; GO:0005615; GO:0016021; GO:0004222; GO:0006508; GO:0008270 Golgi apparatus; endoplasmic reticulum; extracellular space; integral to membrane; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR000718; IPR018497; IPR008753; "Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]" MMEL1 MELL1 MMEL2 NEP2 Homo sapiens (Human) TR38983_c0_g1_i2 Q495T6 MMEL1_HUMAN 5.00E-172 GO:0005794; GO:0005783; GO:0005615; GO:0016021; GO:0004222; GO:0006508; GO:0008270 Golgi apparatus; endoplasmic reticulum; extracellular space; integral to membrane; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR000718; IPR018497; IPR008753; "Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]" MMEL1 MELL1 MMEL2 NEP2 Homo sapiens (Human) TR38984_c3_g1_i1 Q8BKZ9 ODPX_MOUSE 4.00E-111 GO:0005759; GO:0005739; GO:0016746 "mitochondrial matrix; mitochondrion; transferase activity, transferring acyl groups" IPR003016; IPR001078; IPR000089; IPR023213; IPR004167; IPR011053; "Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X)" Pdhx Mus musculus (Mouse) TR38985_c1_g2_i2 Q6ZPY2 SMG5_MOUSE 8.00E-73 GO:0005737; GO:0000184; GO:0005634; GO:0051721; GO:0035303 "cytoplasm; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus; protein phosphatase 2A binding; regulation of dephosphorylation" IPR018834; IPR019458; IPR002716; Protein SMG5 (EST1-like protein B) (SMG-5 homolog) Smg5 Est1b Kiaa1089 Mus musculus (Mouse) TR38986_c0_g1_i1 Q69ZW3 EHBP1_MOUSE 1.00E-81 GO:0005737; GO:0016020 cytoplasm; membrane IPR001715; IPR022735; IPR019448; EH domain-binding protein 1 Ehbp1 Kiaa0903 Mus musculus (Mouse) TR38986_c0_g1_i2 Q8N3D4 EH1L1_HUMAN 2.00E-67 IPR001715; IPR022735; IPR019448; EH domain-binding protein 1-like protein 1 EHBP1L1 Homo sapiens (Human) TR38986_c2_g1_i1 Q69ZW3 EHBP1_MOUSE 3.00E-48 GO:0005737; GO:0016020 cytoplasm; membrane IPR001715; IPR022735; IPR019448; EH domain-binding protein 1 Ehbp1 Kiaa0903 Mus musculus (Mouse) TR38989_c1_g1_i1 Q91VB4 HPS3_MOUSE 2.00E-24 GO:0005737; GO:0006996; GO:0043473 cytoplasm; organelle organization; pigmentation IPR017216; IPR028167; Hermansky-Pudlak syndrome 3 protein homolog (Cocoa protein) Hps3 Coa Mus musculus (Mouse) TR38990_c1_g1_i2 Q54IT3 AOFA_DICDI 2.00E-77 GO:0016491 oxidoreductase activity IPR002937; IPR001613; Probable flavin-containing monoamine oxidase A (EC 1.4.3.4) maoA DDB_G0288541 Dictyostelium discoideum (Slime mold) TR38990_c1_g1_i3 Q6NSN2 AOF_DANRE 0 GO:0006584; GO:0042402; GO:0016021; GO:0005741; GO:0042135; GO:0008131 catecholamine metabolic process; cellular biogenic amine catabolic process; integral to membrane; mitochondrial outer membrane; neurotransmitter catabolic process; primary amine oxidase activity IPR002937; IPR001613; IPR016040; Amine oxidase [flavin-containing] (EC 1.4.3.4) (Monoamine oxidase) (MAO) (Z-MAO) mao zgc:85761 Danio rerio (Zebrafish) (Brachydanio rerio) TR38992_c1_g1_i1 Q96MB7 HARB1_HUMAN 7.00E-13 GO:0005813; GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 centrosome; cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) HARBI1 C11orf77 Homo sapiens (Human) TR38993_c0_g1_i1 Q3B7L6 SRSF6_BOVIN 6.00E-25 GO:0003723; GO:0008380; GO:0006397; GO:0048025; GO:0000166; GO:0005634 "RNA binding; RNA splicing; mRNA processing; negative regulation of mRNA splicing, via spliceosome; nucleotide binding; nucleus" IPR012677; IPR000504; "Serine/arginine-rich splicing factor 6 (Splicing factor, arginine/serine-rich 6)" SRSF6 SFRS6 Bos taurus (Bovine) TR38993_c0_g2_i1 Q8VE97 SRSF4_MOUSE 1.00E-26 GO:0003723; GO:0008380; GO:0006397; GO:0048025; GO:0016607; GO:0000166 "RNA binding; RNA splicing; mRNA processing; negative regulation of mRNA splicing, via spliceosome; nuclear speck; nucleotide binding" IPR012677; IPR000504; "Serine/arginine-rich splicing factor 4 (Splicing factor, arginine/serine-rich 4)" Srsf4 Sfrs4 MNCb-2616 Mus musculus (Mouse) TR38993_c3_g1_i1 Q8VE97 SRSF4_MOUSE 6.00E-66 GO:0003723; GO:0008380; GO:0006397; GO:0048025; GO:0016607; GO:0000166 "RNA binding; RNA splicing; mRNA processing; negative regulation of mRNA splicing, via spliceosome; nuclear speck; nucleotide binding" IPR012677; IPR000504; "Serine/arginine-rich splicing factor 4 (Splicing factor, arginine/serine-rich 4)" Srsf4 Sfrs4 MNCb-2616 Mus musculus (Mouse) TR38993_c3_g1_i2 O22315 SRSF1_ARATH 3.00E-21 GO:0003723; GO:0008380; GO:0035061; GO:0006397; GO:0016607; GO:0000166 Q9LY75 RNA binding; RNA splicing; interchromatin granule; mRNA processing; nuclear speck; nucleotide binding IPR012677; IPR000504; Pre-mRNA-splicing factor SF2 (SR1 protein) SF2 At1g02840 F22D16.16 F22D16_30 Arabidopsis thaliana (Mouse-ear cress) TR38993_c4_g2_i10 Q23121 RSP1_CAEEL 6.00E-42 GO:0003723; GO:0030154; GO:0000398; GO:0007275; GO:0000166; GO:0005634; GO:0040009; GO:0007283 "RNA binding; cell differentiation; mRNA splicing, via spliceosome; multicellular organismal development; nucleotide binding; nucleus; regulation of growth rate; spermatogenesis" IPR012677; IPR000504; "Probable splicing factor, arginine/serine-rich 1 (CeSRp75) (RNA-binding protein srp-5)" rsp-1 srp-5 W02B12.3 Caenorhabditis elegans TR38993_c4_g2_i3 Q9P3U1 YKX5_SCHPO 9.00E-08 GO:0003723; GO:0005829; GO:0000166; GO:0005634; GO:0016973 RNA binding; cytosol; nucleotide binding; nucleus; poly(A)+ mRNA export from nucleus IPR012677; IPR000504; Uncharacterized RNA-binding protein C328.05 SPAC328.05 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38993_c4_g2_i4 Q13247 SRSF6_HUMAN 4.00E-74 GO:0003723; GO:0031124; GO:0006406; GO:0006376; GO:0048025; GO:0005654; GO:0000166; GO:0006369 "RNA binding; mRNA 3'-end processing; mRNA export from nucleus; mRNA splice site selection; negative regulation of mRNA splicing, via spliceosome; nucleoplasm; nucleotide binding; termination of RNA polymerase II transcription" IPR012677; IPR000504; "Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)" SRSF6 SFRS6 SRP55 Homo sapiens (Human) TR38993_c4_g2_i6 Q9FYB7 RSZ32_ARATH 4.00E-21 GO:0000398; GO:0003676; GO:0000166; GO:0005634; GO:0008270 "mRNA splicing, via spliceosome; nucleic acid binding; nucleotide binding; nucleus; zinc ion binding" IPR012677; IPR000504; IPR001878; Serine/arginine-rich splicing factor RS2Z32 (RS-containing zinc finger protein 32) (At-RS2Z32) (At-RSZ32) RS2Z32 RSZ32 At3g53500 F4P12.200 Arabidopsis thaliana (Mouse-ear cress) TR38993_c4_g2_i9 Q8VE97 SRSF4_MOUSE 1.00E-78 GO:0003723; GO:0008380; GO:0006397; GO:0048025; GO:0016607; GO:0000166 "RNA binding; RNA splicing; mRNA processing; negative regulation of mRNA splicing, via spliceosome; nuclear speck; nucleotide binding" IPR012677; IPR000504; "Serine/arginine-rich splicing factor 4 (Splicing factor, arginine/serine-rich 4)" Srsf4 Sfrs4 MNCb-2616 Mus musculus (Mouse) TR38994_c1_g3_i2 Q5RC51 PARN_PONAB 4.00E-26 GO:0003723; GO:0005737; GO:0046872; GO:0000184; GO:0090305; GO:0000166; GO:0005634; GO:0004535 "RNA binding; cytoplasm; metal ion binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleic acid phosphodiester bond hydrolysis; nucleotide binding; nucleus; poly(A)-specific ribonuclease activity" IPR012677; IPR014789; IPR001374; IPR006941; IPR012337; Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Polyadenylate-specific ribonuclease) PARN Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR38994_c1_g3_i3 Q8NA58 PNDC1_HUMAN 3.00E-31 GO:0016021; GO:0003676; GO:0005634 integral to membrane; nucleic acid binding; nucleus IPR006941; IPR012337; Poly(A)-specific ribonuclease PARN-like domain-containing protein 1 PNLDC1 Homo sapiens (Human) TR38996_c0_g1_i11 Q10743 ADA10_RAT 1.00E-40 GO:0005798; GO:0007219; GO:0009986; GO:0001701; GO:0016021; GO:0016020; GO:0006509; GO:0046872; GO:0004222; GO:0007162; GO:0005634; GO:0042803; GO:0019901; GO:0006468; GO:0045670; GO:0005802 Golgi-associated vesicle; Notch signaling pathway; cell surface; in utero embryonic development; integral to membrane; membrane; membrane protein ectodomain proteolysis; metal ion binding; metalloendopeptidase activity; negative regulation of cell adhesion; nucleus; protein homodimerization activity; protein kinase binding; protein phosphorylation; regulation of osteoclast differentiation; trans-Golgi network IPR027053; IPR001762; IPR024079; IPR001590; Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c) (Fragment) Adam10 Madm Rattus norvegicus (Rat) TR38996_c0_g1_i4 Q10743 ADA10_RAT 2.00E-65 GO:0005798; GO:0007219; GO:0009986; GO:0001701; GO:0016021; GO:0016020; GO:0006509; GO:0046872; GO:0004222; GO:0007162; GO:0005634; GO:0042803; GO:0019901; GO:0006468; GO:0045670; GO:0005802 Golgi-associated vesicle; Notch signaling pathway; cell surface; in utero embryonic development; integral to membrane; membrane; membrane protein ectodomain proteolysis; metal ion binding; metalloendopeptidase activity; negative regulation of cell adhesion; nucleus; protein homodimerization activity; protein kinase binding; protein phosphorylation; regulation of osteoclast differentiation; trans-Golgi network IPR027053; IPR001762; IPR024079; IPR001590; Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c) (Fragment) Adam10 Madm Rattus norvegicus (Rat) TR38996_c0_g1_i6 Q6X1T6 VM3E6_ECHOC 3.00E-09 GO:0005576; GO:0004222; GO:0016504; GO:0006508; GO:0008270 extracellular region; metalloendopeptidase activity; peptidase activator activity; proteolysis; zinc ion binding IPR006586; IPR001762; IPR018358; IPR024079; IPR001590; IPR002870; Zinc metalloproteinase-disintegrin-like EoMP06 (EC 3.4.24.-) (Prothrombin activator EoMP06) (Snake venom metalloprotease) (SVMP) (Fragment) Echis ocellatus (Ocellated saw-scaled viper) TR38997_c0_g2_i1 Q08E52 PAK1_BOVIN 4.00E-132 GO:0005524; GO:0005794; GO:0031532; GO:0006915; GO:0048754; GO:0005911; GO:0005518; GO:0006887; GO:0005925; GO:0060244; GO:0005886; GO:0043507; GO:0033148; GO:0033138; GO:0051496; GO:0046777; GO:0004674; GO:0001726; GO:0042060 ATP binding; Golgi apparatus; actin cytoskeleton reorganization; apoptotic process; branching morphogenesis of an epithelial tube; cell-cell junction; collagen binding; exocytosis; focal adhesion; negative regulation of cell proliferation involved in contact inhibition; plasma membrane; positive regulation of JUN kinase activity; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of peptidyl-serine phosphorylation; positive regulation of stress fiber assembly; protein autophosphorylation; protein serine/threonine kinase activity; ruffle; wound healing IPR000095; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) PAK1 Bos taurus (Bovine) TR38997_c0_g2_i2 Q08E52 PAK1_BOVIN 6.00E-132 GO:0005524; GO:0005794; GO:0031532; GO:0006915; GO:0048754; GO:0005911; GO:0005518; GO:0006887; GO:0005925; GO:0060244; GO:0005886; GO:0043507; GO:0033148; GO:0033138; GO:0051496; GO:0046777; GO:0004674; GO:0001726; GO:0042060 ATP binding; Golgi apparatus; actin cytoskeleton reorganization; apoptotic process; branching morphogenesis of an epithelial tube; cell-cell junction; collagen binding; exocytosis; focal adhesion; negative regulation of cell proliferation involved in contact inhibition; plasma membrane; positive regulation of JUN kinase activity; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of peptidyl-serine phosphorylation; positive regulation of stress fiber assembly; protein autophosphorylation; protein serine/threonine kinase activity; ruffle; wound healing IPR000095; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) PAK1 Bos taurus (Bovine) TR38997_c0_g2_i3 Q12851 M4K2_HUMAN 4.00E-47 GO:0005524; GO:0000139; GO:0007257; GO:0016323; GO:0006955; GO:0045087; GO:0046330; GO:0004674; GO:0005083; GO:0006903 Q13233 ATP binding; Golgi membrane; activation of JUN kinase activity; basolateral plasma membrane; immune response; innate immune response; positive regulation of JNK cascade; protein serine/threonine kinase activity; small GTPase regulator activity; vesicle targeting IPR001180; IPR011009; IPR021160; IPR000719; IPR017441; IPR002290; Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) MAP4K2 GCK RAB8IP Homo sapiens (Human) TR38997_c0_g2_i5 Q4P5N0 STE20_USTMA 2.00E-114 GO:0005524; GO:0005737; GO:0005634; GO:0004674; GO:0019236 ATP binding; cytoplasm; nucleus; protein serine/threonine kinase activity; response to pheromone IPR000095; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase SMU1 (EC 2.7.11.1) SMU1 STE20 UM04583 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR38998_c1_g1_i2 Q9D799 FMT_MOUSE 3.00E-67 GO:0004479; GO:0005739; GO:0006413 methionyl-tRNA formyltransferase activity; mitochondrion; translational initiation IPR005794; IPR005793; IPR002376; IPR015518; "Methionyl-tRNA formyltransferase, mitochondrial (MtFMT) (EC 2.1.2.9)" Mtfmt Fmt Mus musculus (Mouse) TR38998_c1_g1_i3 B3DXI7 FMT_METI4 7.00E-24 GO:0004479; GO:0032259; GO:0008168; GO:0006413 methionyl-tRNA formyltransferase activity; methylation; methyltransferase activity; translational initiation IPR005794; IPR005793; IPR002376; IPR011034; IPR001555; IPR015518; Methionyl-tRNA formyltransferase (EC 2.1.2.9) fmt Minf_0161 Methylacidiphilum infernorum (isolate V4) (Methylokorus infernorum (strain V4)) TR38998_c1_g1_i4 B5YF45 FMT_DICT6 3.00E-27 GO:0004479; GO:0032259; GO:0008168; GO:0006413 methionyl-tRNA formyltransferase activity; methylation; methyltransferase activity; translational initiation IPR005794; IPR005793; IPR002376; IPR011034; IPR001555; IPR015518; Methionyl-tRNA formyltransferase (EC 2.1.2.9) fmt DICTH_1334 Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12) TR38998_c1_g1_i5 Q9D799 FMT_MOUSE 5.00E-68 GO:0004479; GO:0005739; GO:0006413 methionyl-tRNA formyltransferase activity; mitochondrion; translational initiation IPR005794; IPR005793; IPR002376; IPR015518; "Methionyl-tRNA formyltransferase, mitochondrial (MtFMT) (EC 2.1.2.9)" Mtfmt Fmt Mus musculus (Mouse) TR38999_c1_g1_i2 F1RCR6 TRIPC_DANRE 0 GO:0006281; GO:0009790; GO:2000780; GO:1901315; GO:0005654; GO:0042787; GO:0006974; GO:0004842 DNA repair; embryo development; negative regulation of double-strand break repair; negative regulation of histone H2A K63-linked ubiquitination; nucleoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; response to DNA damage stimulus; ubiquitin-protein ligase activity IPR011989; IPR016024; IPR000569; IPR004170; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIP12 (EC 6.3.2.-) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) trip12 si:ch211-272f3.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR38999_c1_g1_i3 Q14669 TRIPC_HUMAN 2.00E-84 GO:0006281; GO:0005737; GO:0009790; GO:2000780; GO:1901315; GO:0005654; GO:0042787; GO:0006974; GO:0046966; GO:0004842 DNA repair; cytoplasm; embryo development; negative regulation of double-strand break repair; negative regulation of histone H2A K63-linked ubiquitination; nucleoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; response to DNA damage stimulus; thyroid hormone receptor binding; ubiquitin-protein ligase activity IPR011989; IPR016024; IPR000569; IPR004170; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIP12 (EC 6.3.2.-) (E3 ubiquitin-protein ligase for Arf) (ULF) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) TRIP12 KIAA0045 ULF Homo sapiens (Human) TR39001_c0_g1_i4 Q21735 NTF2_CAEEL 4.00E-20 GO:0005737; GO:0015031 cytoplasm; protein transport IPR002075; IPR018222; Probable nuclear transport factor 2 (NTF-2) ran-4 R05D11.3 Caenorhabditis elegans TR39001_c0_g1_i9 Q21735 NTF2_CAEEL 4.00E-20 GO:0005737; GO:0015031 cytoplasm; protein transport IPR002075; IPR018222; Probable nuclear transport factor 2 (NTF-2) ran-4 R05D11.3 Caenorhabditis elegans TR39002_c6_g2_i2 Q05688 IGF1R_BOVIN 4.00E-151 GO:0005524; GO:0006955; GO:0051389; GO:0043559; GO:0043560; GO:0005520; GO:0005010; GO:0016021; GO:0043231; GO:0043066; GO:0043548; GO:0048015; GO:0045740; GO:0030335; GO:0046777; GO:0051262; GO:0046328 ATP binding; immune response; inactivation of MAPKK activity; insulin binding; insulin receptor substrate binding; insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; integral to membrane; intracellular membrane-bounded organelle; negative regulation of apoptotic process; phosphatidylinositol 3-kinase binding; phosphatidylinositol-mediated signaling; positive regulation of DNA replication; positive regulation of cell migration; protein autophosphorylation; protein tetramerization; regulation of JNK cascade IPR003961; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR002011; Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (Fragment) IGF1R Bos taurus (Bovine) TR39002_c6_g2_i4 Q05688 IGF1R_BOVIN 8.00E-147 GO:0005524; GO:0006955; GO:0051389; GO:0043559; GO:0043560; GO:0005520; GO:0005010; GO:0016021; GO:0043231; GO:0043066; GO:0043548; GO:0048015; GO:0045740; GO:0030335; GO:0046777; GO:0051262; GO:0046328 ATP binding; immune response; inactivation of MAPKK activity; insulin binding; insulin receptor substrate binding; insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; integral to membrane; intracellular membrane-bounded organelle; negative regulation of apoptotic process; phosphatidylinositol 3-kinase binding; phosphatidylinositol-mediated signaling; positive regulation of DNA replication; positive regulation of cell migration; protein autophosphorylation; protein tetramerization; regulation of JNK cascade IPR003961; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR002011; Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (Fragment) IGF1R Bos taurus (Bovine) TR39003_c0_g1_i1 Q8R2Y3 DOLK_MOUSE 6.00E-41 GO:0004168; GO:0043048; GO:0030176 dolichol kinase activity; dolichyl monophosphate biosynthetic process; integral to endoplasmic reticulum membrane IPR026566; Dolichol kinase (EC 2.7.1.108) (Transmembrane protein 15) Dolk Tmem15 Mus musculus (Mouse) TR39004_c0_g1_i1 P19532 TFE3_HUMAN 4.00E-53 GO:0005737; GO:0006959; GO:0005634; GO:0045785; GO:0045944; GO:0045670; GO:0003700; GO:0044212; GO:0006351 "cytoplasm; humoral immune response; nucleus; positive regulation of cell adhesion; positive regulation of transcription from RNA polymerase II promoter; regulation of osteoclast differentiation; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR011598; IPR024097; IPR021802; IPR024100; Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) TFE3 BHLHE33 Homo sapiens (Human) TR39004_c0_g1_i2 Q05B92 TFE3_BOVIN 8.00E-46 GO:0005737; GO:0006959; GO:0005634; GO:0045785; GO:0045944; GO:0045670; GO:0003700; GO:0044212; GO:0006351 "cytoplasm; humoral immune response; nucleus; positive regulation of cell adhesion; positive regulation of transcription from RNA polymerase II promoter; regulation of osteoclast differentiation; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR011598; IPR024097; IPR021802; IPR024100; Transcription factor E3 TFE3 Bos taurus (Bovine) TR39005_c0_g2_i1 Q2QPW2 C3H67_ORYSJ 1.00E-07 GO:0003677; GO:0046872 DNA binding; metal ion binding IPR002110; IPR020683; IPR000571; Zinc finger CCCH domain-containing protein 67 (OsC3H67) Os12g0515500 LOC_Os12g33090 Oryza sativa subsp. japonica (Rice) TR39005_c0_g2_i2 Q9C0B0 UNK_HUMAN 1.00E-161 GO:0008270 zinc ion binding IPR000571; IPR001841; RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) UNK KIAA1753 ZC3H5 ZC3HDC5 Homo sapiens (Human) TR39007_c0_g1_i1 Q8BTW8 CK5P1_MOUSE 0 GO:0051539; GO:0005737; GO:0046872; GO:0045736; GO:0006400; GO:0016740 "4 iron, 4 sulfur cluster binding; cytoplasm; metal ion binding; negative regulation of cyclin-dependent protein serine/threonine kinase activity; tRNA modification; transferase activity" IPR006638; IPR023970; IPR005839; IPR020612; IPR013848; IPR006463; IPR007197; IPR023404; IPR002792; CDK5 regulatory subunit-associated protein 1 (CDK5 activator-binding protein C42) Cdk5rap1 Mus musculus (Mouse) TR39007_c0_g1_i4 A6LEM6 MIAB_PARD8 2.00E-87 GO:0051539; GO:0005737; GO:0005506; GO:0006400; GO:0016740 "4 iron, 4 sulfur cluster binding; cytoplasm; iron ion binding; tRNA modification; transferase activity" IPR006638; IPR023970; IPR005839; IPR020612; IPR013848; IPR006463; IPR012340; IPR007197; IPR023404; IPR002792; (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB (EC 2.-.-.-) (tRNA-i(6)A37 methylthiotransferase) miaB BDI_2415 Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) TR39008_c0_g1_i1 Q13042 CDC16_HUMAN 0 GO:0005680; GO:0031145; GO:0051301; GO:0008283; GO:0005813; GO:0005829; GO:0007067; GO:0007094; GO:0051436; GO:0005654; GO:0051437; GO:0070979; GO:0005876 Q8NHZ8 anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; cell proliferation; centrosome; cytosol; mitosis; mitotic spindle assembly checkpoint; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; protein K11-linked ubiquitination; spindle microtubule IPR013026; IPR011990; IPR001440; IPR019734; Protein modification; protein ubiquitination. Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6) CDC16 ANAPC6 Homo sapiens (Human) TR39008_c0_g1_i3 Q13042 CDC16_HUMAN 5.00E-79 GO:0005680; GO:0031145; GO:0051301; GO:0008283; GO:0005813; GO:0005829; GO:0007067; GO:0007094; GO:0051436; GO:0005654; GO:0051437; GO:0070979; GO:0005876 Q8NHZ8 anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; cell proliferation; centrosome; cytosol; mitosis; mitotic spindle assembly checkpoint; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; protein K11-linked ubiquitination; spindle microtubule IPR013026; IPR011990; IPR001440; IPR019734; Protein modification; protein ubiquitination. Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6) CDC16 ANAPC6 Homo sapiens (Human) TR39009_c0_g1_i3 O55201 SPT5H_MOUSE 7.00E-45 GO:0032044; GO:0003682; GO:0032785; GO:0000122; GO:0032786; GO:0016239; GO:0045944; GO:0006368 "DSIF complex; chromatin binding; negative regulation of DNA-dependent transcription, elongation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of DNA-dependent transcription, elongation; positive regulation of macroautophagy; positive regulation of transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter" IPR005824; IPR024945; IPR022581; IPR017071; IPR005100; IPR006645; IPR008991; Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) Supt5h Supt5 Mus musculus (Mouse) TR39009_c0_g1_i6 Q5ZI08 SPT5H_CHICK 6.00E-44 GO:0032044; GO:0032784; GO:0006357; GO:0006351 "DSIF complex; regulation of DNA-dependent transcription, elongation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR005824; IPR024945; IPR022581; IPR017071; IPR005100; IPR006645; IPR008991; Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) SUPT5H RCJMB04_31j17 Gallus gallus (Chicken) TR39009_c0_g1_i7 Q9STN3 SPT51_ARATH 1.00E-12 GO:0005634; GO:0032784; GO:0006357; GO:0005840; GO:0003735; GO:0006351; GO:0006412 "nucleus; regulation of DNA-dependent transcription, elongation; regulation of transcription from RNA polymerase II promoter; ribosome; structural constituent of ribosome; transcription, DNA-dependent; translation" IPR005824; IPR005825; IPR017071; IPR005100; IPR006645; IPR008991; Putative transcription elongation factor SPT5 homolog 1 At4g08350 T28D5.40 Arabidopsis thaliana (Mouse-ear cress) TR3901_c0_g1_i1 P11369 POL2_MOUSE 1.00E-08 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR013544; IPR005135; IPR000477; Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element-1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] Pol Gm17492 Mus musculus (Mouse) TR39010_c3_g1_i1 Q8K0H5 TAF10_MOUSE 2.00E-43 GO:0003677; GO:0006352; GO:0000082; GO:0006915; GO:0043623; GO:0009790; GO:0070365; GO:0035264; GO:0051101; GO:0006355; GO:0005669 "DNA binding; DNA-dependent transcription, initiation; G1/S transition of mitotic cell cycle; apoptotic process; cellular protein complex assembly; embryo development; hepatocyte differentiation; multicellular organism growth; regulation of DNA binding; regulation of transcription, DNA-dependent; transcription factor TFIID complex" IPR003923; Transcription initiation factor TFIID subunit 10 (Transcription initiation factor TFIID 30 kDa subunit) (TAF(II)30) (TAFII-30) (TAFII30) (mTAFII30) Taf10 Taf2h Tafii30 Mus musculus (Mouse) TR39013_c3_g1_i1 O75379 VAMP4_HUMAN 3.00E-13 GO:0000139; GO:0043001; GO:0031201; GO:0005768; GO:0016021; GO:0005764; GO:0042996; GO:0005802 Golgi membrane; Golgi to plasma membrane protein transport; SNARE complex; endosome; integral to membrane; lysosome; regulation of Golgi to plasma membrane protein transport; trans-Golgi network IPR001388; IPR016444; Vesicle-associated membrane protein 4 (VAMP-4) VAMP4 Homo sapiens (Human) TR39013_c3_g1_i5 P47194 SYB_LOLPE 6.00E-36 GO:0030054; GO:0016021; GO:0043005; GO:0030672; GO:0016192 cell junction; integral to membrane; neuron projection; synaptic vesicle membrane; vesicle-mediated transport IPR001388; IPR016444; Synaptobrevin Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR39015_c2_g1_i2 P70031 CCKAR_XENLA 1.00E-07 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR009126; IPR000276; IPR017452; Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) TR39016_c0_g1_i1 Q29A33 ATX2_DROPS 5.00E-26 GO:0022416; GO:0048749; GO:0005737; GO:0009994; GO:0030833 chaeta development; compound eye development; cytoplasm; oocyte differentiation; regulation of actin filament polymerization IPR009604; IPR025852; Ataxin-2 homolog Atx2 GA18704 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR39016_c0_g1_i3 Q99700 ATX2_HUMAN 1.00E-42 GO:0005794; GO:0003723; GO:0016070; GO:0050658; GO:0008219; GO:0021702; GO:0033962; GO:0010494; GO:0048872; GO:0040015; GO:0002091; GO:0050905; GO:0048812; GO:0005634; GO:0048471; GO:0005844; GO:0006417; GO:0034063; GO:0005802 P54253; P26196; Q13283; P11940; Q99962; Q99963 Golgi apparatus; RNA binding; RNA metabolic process; RNA transport; cell death; cerebellar Purkinje cell differentiation; cytoplasmic mRNA processing body assembly; cytoplasmic stress granule; homeostasis of number of cells; negative regulation of multicellular organism growth; negative regulation of receptor internalization; neuromuscular process; neuron projection morphogenesis; nucleus; perinuclear region of cytoplasm; polysome; regulation of translation; stress granule assembly; trans-Golgi network IPR009818; IPR010920; IPR009604; IPR025852; Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) ATXN2 ATX2 SCA2 TNRC13 Homo sapiens (Human) TR39017_c0_g1_i1 Q21827 GPTC1_CAEEL 2.00E-29 GO:0003676 Q19986 nucleic acid binding IPR011666; IPR000467; G patch domain-containing protein 1 homolog R07E5.1 Caenorhabditis elegans TR39017_c1_g1_i3 Q24K12 GPTC1_BOVIN 2.00E-91 GO:0003676 nucleic acid binding IPR011666; IPR000467; G patch domain-containing protein 1 GPATCH1 GPATC1 Bos taurus (Bovine) TR39019_c1_g1_i3 P62074 TIM10_RAT 7.00E-33 GO:0072321; GO:0046872; GO:0005743; GO:0042719; GO:0045039; GO:0005215 chaperone-mediated protein transport; metal ion binding; mitochondrial inner membrane; mitochondrial intermembrane space protein transporter complex; protein import into mitochondrial inner membrane; transporter activity IPR004217; IPR027247; Mitochondrial import inner membrane translocase subunit Tim10 Timm10 Tim10 Rattus norvegicus (Rat) TR39019_c1_g1_i4 Q4WJX5 TIM10_ASPFU 1.00E-19 GO:0046872; GO:0005743; GO:0042719; GO:0045039; GO:0008565 metal ion binding; mitochondrial inner membrane; mitochondrial intermembrane space protein transporter complex; protein import into mitochondrial inner membrane; protein transporter activity IPR027100; IPR004217; IPR027247; Mitochondrial import inner membrane translocase subunit tim10 tim10 AFUA_1G04470 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) TR39022_c3_g1_i1 O15394 NCAM2_HUMAN 1.00E-59 GO:0030424; GO:0016021; GO:0007158; GO:0005886 axon; integral to membrane; neuron cell-cell adhesion; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR009138; Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2) NCAM2 NCAM21 Homo sapiens (Human) TR39022_c3_g1_i2 P34082 FAS2_DROME 7.00E-67 GO:0001746; GO:0031225; GO:0007413; GO:0048149; GO:0048667; GO:0005737; GO:0007156; GO:0048803; GO:0016021; GO:0097482; GO:0016319; GO:0042059; GO:0031594; GO:0007528; GO:0008355; GO:0045211; GO:0048786; GO:0042734; GO:0036062; GO:0008360; GO:0008582; GO:0035158; GO:0035159; GO:0007614; GO:0072553; GO:0061174 P14599; Q9VR25; Q59E14; Q9GQQ6 "Bolwig's organ morphogenesis; anchored to membrane; axonal fasciculation; behavioral response to ethanol; cell morphogenesis involved in neuron differentiation; cytoplasm; homophilic cell adhesion; imaginal disc-derived male genitalia morphogenesis; integral to membrane; muscle cell postsynaptic density; mushroom body development; negative regulation of epidermal growth factor receptor signaling pathway; neuromuscular junction; neuromuscular junction development; olfactory learning; postsynaptic membrane; presynaptic active zone; presynaptic membrane; presynaptic periactive zone; regulation of cell shape; regulation of synaptic growth at neuromuscular junction; regulation of tube diameter, open tracheal system; regulation of tube length, open tracheal system; short-term memory; terminal button organization; type I terminal bouton" IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR009138; Fasciclin-2 (Fasciclin II) (FAS II) Fas2 CG3665 Drosophila melanogaster (Fruit fly) TR39022_c3_g1_i3 P34082 FAS2_DROME 8.00E-67 GO:0001746; GO:0031225; GO:0007413; GO:0048149; GO:0048667; GO:0005737; GO:0007156; GO:0048803; GO:0016021; GO:0097482; GO:0016319; GO:0042059; GO:0031594; GO:0007528; GO:0008355; GO:0045211; GO:0048786; GO:0042734; GO:0036062; GO:0008360; GO:0008582; GO:0035158; GO:0035159; GO:0007614; GO:0072553; GO:0061174 P14599; Q9VR25; Q59E14; Q9GQQ6 "Bolwig's organ morphogenesis; anchored to membrane; axonal fasciculation; behavioral response to ethanol; cell morphogenesis involved in neuron differentiation; cytoplasm; homophilic cell adhesion; imaginal disc-derived male genitalia morphogenesis; integral to membrane; muscle cell postsynaptic density; mushroom body development; negative regulation of epidermal growth factor receptor signaling pathway; neuromuscular junction; neuromuscular junction development; olfactory learning; postsynaptic membrane; presynaptic active zone; presynaptic membrane; presynaptic periactive zone; regulation of cell shape; regulation of synaptic growth at neuromuscular junction; regulation of tube diameter, open tracheal system; regulation of tube length, open tracheal system; short-term memory; terminal button organization; type I terminal bouton" IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR009138; Fasciclin-2 (Fasciclin II) (FAS II) Fas2 CG3665 Drosophila melanogaster (Fruit fly) TR39024_c1_g3_i2 Q8SR09 HD2_ENCCU 2.00E-11 GO:0005634; GO:0043565; GO:0003700 nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR001356; IPR008422; IPR009057; Homeobox protein HD-2 (EcHD-2) HD-2 ECU10_1480 Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) TR39025_c0_g1_i1 Q3UY23 FDXA1_MOUSE 2.00E-12 GO:0005524; GO:0000287; GO:0004826; GO:0006432; GO:0000049; GO:0008033 ATP binding; magnesium ion binding; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding; tRNA processing IPR019446; IPR005121; Ferredoxin-fold anticodon-binding domain-containing protein 1 homolog (FDX-ACDB domain-containing protein 1) Fdxacb1 Mus musculus (Mouse) TR39025_c0_g1_i2 Q99M01 SYFM_MOUSE 1.00E-159 GO:0005524; GO:0000287; GO:0005759; GO:0005739; GO:0004826; GO:0006432; GO:0000049; GO:0008033 ATP binding; magnesium ion binding; mitochondrial matrix; mitochondrion; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding; tRNA processing IPR006195; IPR004530; IPR002319; IPR005121; "Phenylalanine--tRNA ligase, mitochondrial (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase) (PheRS)" Fars2 Fars1 Mus musculus (Mouse) TR39025_c0_g1_i4 Q8DL09 SYFA_THEEB 4.00E-20 GO:0005524; GO:0005737; GO:0000287; GO:0004826; GO:0006432; GO:0000049 ATP binding; cytoplasm; magnesium ion binding; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding IPR006195; IPR004529; IPR004188; IPR022911; IPR002319; IPR010978; Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) pheS tlr0690 Thermosynechococcus elongatus (strain BP-1) TR39025_c0_g1_i6 Q6F872 SYFA_ACIAD 9.00E-23 GO:0005524; GO:0005737; GO:0000287; GO:0004826; GO:0006432; GO:0000049 ATP binding; cytoplasm; magnesium ion binding; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding IPR006195; IPR004529; IPR004188; IPR022911; IPR002319; IPR010978; Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) pheS ACIAD3042 Acinetobacter sp. (strain ADP1) TR39026_c2_g1_i1 Q5RBF3 AMPM1_PONAB 1.00E-103 GO:0004177; GO:0009987; GO:0005737; GO:0046872; GO:0008235; GO:0006508 aminopeptidase activity; cellular process; cytoplasm; metal ion binding; metalloexopeptidase activity; proteolysis IPR001714; IPR000994; IPR002467; Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC 3.4.11.18) (Peptidase M 1) METAP1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39026_c2_g1_i2 Q5ZIM5 AMPM1_CHICK 2.00E-104 GO:0004177; GO:0009987; GO:0005737; GO:0046872; GO:0008235; GO:0006508 aminopeptidase activity; cellular process; cytoplasm; metal ion binding; metalloexopeptidase activity; proteolysis IPR001714; IPR000994; IPR002467; Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC 3.4.11.18) (Peptidase M 1) METAP1 RCJMB04_24o19 Gallus gallus (Chicken) TR39026_c2_g4_i1 P53579 AMPM1_SYNY3 1.00E-50 GO:0004177; GO:0009987; GO:0046872; GO:0008235; GO:0006508 aminopeptidase activity; cellular process; metal ion binding; metalloexopeptidase activity; proteolysis IPR001714; IPR000994; IPR002467; Methionine aminopeptidase A (MAP A) (MetAP A) (EC 3.4.11.18) (Peptidase M) slr0918 Synechocystis sp. (strain PCC 6803 / Kazusa) TR39026_c2_g4_i2 P53580 AMPM2_SYNY3 1.00E-43 GO:0004177; GO:0009987; GO:0046872; GO:0008235; GO:0006508 aminopeptidase activity; cellular process; metal ion binding; metalloexopeptidase activity; proteolysis IPR001714; IPR000994; IPR002467; Methionine aminopeptidase B (MAP B) (MetAP B) (EC 3.4.11.18) (Peptidase M) slr0786 Synechocystis sp. (strain PCC 6803 / Kazusa) TR39027_c0_g2_i2 Q15067 ACOX1_HUMAN 2.00E-173 GO:0071949; GO:0003995; GO:0003997; GO:0036109; GO:0033540; GO:0005504; GO:0019395; GO:0050660; GO:0006091; GO:0055088; GO:0005739; GO:0016401; GO:0005782; GO:0005778; GO:0016559; GO:2000189; GO:0006693; GO:0007283; GO:0000038 FAD binding; acyl-CoA dehydrogenase activity; acyl-CoA oxidase activity; alpha-linolenic acid metabolic process; fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid binding; fatty acid oxidation; flavin adenine dinucleotide binding; generation of precursor metabolites and energy; lipid homeostasis; mitochondrion; palmitoyl-CoA oxidase activity; peroxisomal matrix; peroxisomal membrane; peroxisome fission; positive regulation of cholesterol homeostasis; prostaglandin metabolic process; spermatogenesis; very long-chain fatty acid metabolic process IPR006091; IPR012258; IPR002655; IPR009075; IPR013786; IPR009100; Lipid metabolism; peroxisomal fatty acid beta-oxidation. Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX) ACOX1 ACOX Homo sapiens (Human) TR39028_c0_g1_i1 Q9Y2S7 PDIP2_HUMAN 4.00E-71 GO:0003677; GO:0042645; GO:0005634 DNA binding; mitochondrial nucleoid; nucleus IPR007474; IPR011722; Polymerase delta-interacting protein 2 (38 kDa DNA polymerase delta interaction protein) (p38) POLDIP2 PDIP38 POLD4 HSPC017 Homo sapiens (Human) TR39029_c1_g1_i1 Q9VC57 ATLAS_DROME 0 GO:0005525; GO:0003924; GO:0005794; GO:0000139; GO:0007030; GO:0016320; GO:0007029; GO:0016021; GO:0031227; GO:0007019; GO:0007517; GO:0042803; GO:0051260; GO:0031114; GO:0008582; GO:0051124 GTP binding; GTPase activity; Golgi apparatus; Golgi membrane; Golgi organization; endoplasmic reticulum membrane fusion; endoplasmic reticulum organization; integral to membrane; intrinsic to endoplasmic reticulum membrane; microtubule depolymerization; muscle organ development; protein homodimerization activity; protein homooligomerization; regulation of microtubule depolymerization; regulation of synaptic growth at neuromuscular junction; synaptic growth at neuromuscular junction IPR003191; IPR015894; IPR027417; Atlastin (EC 3.6.5.-) atl CG6668 Drosophila melanogaster (Fruit fly) TR39030_c0_g2_i2 Q10739 MMP14_RAT 1.00E-56 GO:0001525; GO:0043615; GO:0048754; GO:0005509; GO:0005737; GO:0001935; GO:0031012; GO:0016021; GO:0030324; GO:0008584; GO:0042470; GO:0004222; GO:0051895; GO:0001503; GO:0001541; GO:0016504; GO:0030307; GO:0030335; GO:0006508; GO:0043627; GO:0001666; GO:0009612; GO:0006979; GO:0003700; GO:0048771; GO:0008270; GO:0031638 angiogenesis; astrocyte cell migration; branching morphogenesis of an epithelial tube; calcium ion binding; cytoplasm; endothelial cell proliferation; extracellular matrix; integral to membrane; lung development; male gonad development; melanosome; metalloendopeptidase activity; negative regulation of focal adhesion assembly; ossification; ovarian follicle development; peptidase activator activity; positive regulation of cell growth; positive regulation of cell migration; proteolysis; response to estrogen stimulus; response to hypoxia; response to mechanical stimulus; response to oxidative stress; sequence-specific DNA binding transcription factor activity; tissue remodeling; zinc ion binding; zymogen activation IPR000585; IPR018487; IPR018486; IPR024079; IPR001818; IPR021190; IPR021805; IPR016293; IPR021158; IPR006026; IPR002477; Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT-MMP) (MT1-MMP) (MT1MMP) Mmp14 Mtmmp Rattus norvegicus (Rat) TR39030_c0_g2_i3 P91953 HE_HEMPU 5.00E-24 GO:0031012; GO:0004222; GO:0006508; GO:0008270 extracellular matrix; metalloendopeptidase activity; proteolysis; zinc ion binding IPR000585; IPR018487; IPR018486; IPR024079; IPR001818; IPR021190; IPR021158; IPR006026; IPR002477; 50 kDa hatching enzyme (HE) (HEZ) (EC 3.4.24.12) (Envelysin) (Sea-urchin-hatching proteinase) [Cleaved into: 38 kDa hatching enzyme; 32 kDa hatching enzyme non-specific; 15 kDa peptide] Hemicentrotus pulcherrimus (Sea urchin) (Strongylocentrotus pulcherrimus) TR39033_c0_g1_i2 P86854 PLCL_MYTGA 9.00E-06 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR39034_c0_g2_i2 Q5F452 MTMR8_CHICK 0 GO:0005635; GO:0035335; GO:0004725 nuclear envelope; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR010569; IPR017906; IPR011993; IPR016130; Myotubularin-related protein 8 (EC 3.1.3.-) MTMR8 RCJMB04_3d12 Gallus gallus (Chicken) TR39034_c0_g2_i4 B3MT31 LST2_DROAN 6.00E-09 GO:0046872 metal ion binding IPR000306; IPR017455; IPR011011; IPR013083; Lateral signaling target protein 2 homolog GF22946 Drosophila ananassae (Fruit fly) TR39036_c0_g1_i2 P70031 CCKAR_XENLA 4.00E-08 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR009126; IPR000276; IPR017452; Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) TR39037_c0_g1_i1 Q34941 COX1_LUMTE 0 GO:0009060; GO:0004129; GO:0009055; GO:0020037; GO:0016021; GO:0005506; GO:0005743; GO:0006119; GO:0070469 aerobic respiration; cytochrome-c oxidase activity; electron carrier activity; heme binding; integral to membrane; iron ion binding; mitochondrial inner membrane; oxidative phosphorylation; respiratory chain IPR000883; IPR023615; IPR023616; Energy metabolism; oxidative phosphorylation. Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide I) COI Lumbricus terrestris (Common earthworm) TR39037_c2_g2_i1 C9J069 CI172_HUMAN 2.00E-45 Uncharacterized protein C9orf172 C9orf172 Homo sapiens (Human) TR39038_c2_g2_i1 Q969Q6 P2R3C_HUMAN 0 GO:0005509; GO:0005813; GO:0005737; GO:0005634 calcium ion binding; centrosome; cytoplasm; nucleus IPR011992; IPR018247; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma (Protein phosphatase subunit G5PR) (Rhabdomyosarcoma antigen MU-RMS-40.6A/6C) PPP2R3C C14orf10 G5PR Homo sapiens (Human) TR3904_c0_g1_i2 P60868 RS20_RAT 1.00E-67 GO:0003723; GO:0022627; GO:0003735; GO:0006412 RNA binding; cytosolic small ribosomal subunit; structural constituent of ribosome; translation IPR001848; IPR018268; IPR027486; IPR005729; 40S ribosomal protein S20 Rps20 Rattus norvegicus (Rat) TR39040_c1_g1_i5 Q20363 SIP1_CAEEL 6.00E-06 GO:0008340 determination of adult lifespan IPR002068; IPR001436; IPR008978; Stress-induced protein 1 sip-1 F43D9.4 Caenorhabditis elegans TR39041_c3_g3_i2 Q9JLJ5 ELOV1_MOUSE 8.00E-16 GO:0005789; GO:0009922; GO:0034625; GO:0019367; GO:0016021; GO:0030148; GO:0042761 "endoplasmic reticulum membrane; fatty acid elongase activity; fatty acid elongation, monounsaturated fatty acid; fatty acid elongation, saturated fatty acid; integral to membrane; sphingolipid biosynthetic process; very long-chain fatty acid biosynthetic process" IPR002076; Elongation of very long chain fatty acids protein 1 (EC 2.3.1.199) (3-keto acyl-CoA synthase Elovl1) (ELOVL fatty acid elongase 1) (ELOVL FA elongase 1) (Very-long-chain 3-oxoacyl-CoA synthase 1) Elovl1 Ssc1 Mus musculus (Mouse) TR39041_c3_g3_i3 Q9JLJ5 ELOV1_MOUSE 7.00E-16 GO:0005789; GO:0009922; GO:0034625; GO:0019367; GO:0016021; GO:0030148; GO:0042761 "endoplasmic reticulum membrane; fatty acid elongase activity; fatty acid elongation, monounsaturated fatty acid; fatty acid elongation, saturated fatty acid; integral to membrane; sphingolipid biosynthetic process; very long-chain fatty acid biosynthetic process" IPR002076; Elongation of very long chain fatty acids protein 1 (EC 2.3.1.199) (3-keto acyl-CoA synthase Elovl1) (ELOVL fatty acid elongase 1) (ELOVL FA elongase 1) (Very-long-chain 3-oxoacyl-CoA synthase 1) Elovl1 Ssc1 Mus musculus (Mouse) TR39043_c1_g1_i1 Q13163 MP2K5_HUMAN 4.00E-109 GO:0005524; GO:0070375; GO:0000187; GO:0071499; GO:0005829; GO:0007507; GO:0046872; GO:0032088; GO:0043066; GO:0090051; GO:2000342; GO:0043154; GO:2001240; GO:0034115; GO:0045415; GO:0060761; GO:0000122; GO:0048011; GO:0005634; GO:0018108; GO:0030307; GO:0050679; GO:0045944; GO:0004672; GO:0004674; GO:0004713; GO:0005819 P62993; Q13164 ATP binding; ERK5 cascade; activation of MAPK activity; cellular response to laminar fluid shear stress; cytosol; heart development; metal ion binding; negative regulation of NF-kappaB transcription factor activity; negative regulation of apoptotic process; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of chemokine (C-X-C motif) ligand 2 production; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of heterotypic cell-cell adhesion; negative regulation of interleukin-8 biosynthetic process; negative regulation of response to cytokine stimulus; negative regulation of transcription from RNA polymerase II promoter; neurotrophin TRK receptor signaling pathway; nucleus; peptidyl-tyrosine phosphorylation; positive regulation of cell growth; positive regulation of epithelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; protein kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; spindle IPR011009; IPR000270; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5) MAP2K5 MEK5 MKK5 PRKMK5 Homo sapiens (Human) TR39044_c0_g1_i1 Q5ZKD5 RRP12_CHICK 6.00E-78 GO:0016021; GO:0031965; GO:0005730 integral to membrane; nuclear membrane; nucleolus IPR011989; IPR016024; IPR012978; RRP12-like protein RRP12 RCJMB04_11j1 Gallus gallus (Chicken) TR39044_c0_g1_i2 Q9Y824 YON1_SCHPO 6.00E-11 GO:0030490; GO:0005634; GO:0043234 maturation of SSU-rRNA; nucleus; protein complex IPR011989; IPR016024; Uncharacterized protein C1105.01 SPBC1105.01 SPBP7E8.03 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR39044_c0_g3_i1 Q5ZKD5 RRP12_CHICK 0 GO:0016021; GO:0031965; GO:0005730 integral to membrane; nuclear membrane; nucleolus IPR011989; IPR016024; IPR012978; RRP12-like protein RRP12 RCJMB04_11j1 Gallus gallus (Chicken) TR39045_c1_g1_i1 Q9WYX8 Y508_THEMA 3.00E-29 GO:0005524; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0009378 ATP binding; DNA binding; DNA recombination; DNA repair; DNA replication; four-way junction helicase activity IPR003593; IPR008824; IPR008921; IPR002589; IPR021886; IPR027417; Uncharacterized protein TM_0508 TM_0508 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR39045_c2_g1_i1 Q460N3 PAR15_HUMAN 1.00E-20 GO:0003950; GO:0005634; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) TR39045_c2_g1_i2 O75367 H2AY_HUMAN 2.00E-12 GO:0001740; GO:0003677; GO:0003682; GO:0016568; GO:0000793; GO:0007549; GO:0000786; GO:0006334 P04626 Barr body; DNA binding; chromatin binding; chromatin modification; condensed chromosome; dosage compensation; nucleosome; nucleosome assembly IPR021171; IPR009072; IPR007125; IPR002119; IPR002589; Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205) H2AFY MACROH2A1 Homo sapiens (Human) TR39045_c4_g2_i1 Q6PFX9 TNKS1_MOUSE 2.00E-13 GO:0005794; GO:0000139; GO:0003950; GO:0016055; GO:0051301; GO:0000775; GO:0051028; GO:0007067; GO:0043392; GO:0000784; GO:0005643; GO:0018105; GO:0018107; GO:0090263; GO:0032212; GO:0045944; GO:0070213; GO:0070198; GO:0070212; GO:0000209; GO:0015031; GO:0000922; GO:0008270 "Golgi apparatus; Golgi membrane; NAD+ ADP-ribosyltransferase activity; Wnt receptor signaling pathway; cell division; chromosome, centromeric region; mRNA transport; mitosis; negative regulation of DNA binding; nuclear chromosome, telomeric region; nuclear pore; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of telomere maintenance via telomerase; positive regulation of transcription from RNA polymerase II promoter; protein auto-ADP-ribosylation; protein localization to chromosome, telomeric region; protein poly-ADP-ribosylation; protein polyubiquitination; protein transport; spindle pole; zinc ion binding" IPR002110; IPR020683; IPR012317; IPR001660; IPR013761; IPR011510; Tankyrase-1 (TANK1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (TRF1-interacting ankyrin-related ADP-ribose polymerase 1) (Tankyrase I) Tnks Tnks1 Mus musculus (Mouse) TR39045_c4_g2_i2 Q460N5 PAR14_HUMAN 1.00E-65 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR39046_c3_g1_i1 P90850 YCF2E_CAEEL 8.00E-108 GO:0008234; GO:0005576; GO:0006955; GO:0030247; GO:0006508; GO:0005044 cysteine-type peptidase activity; extracellular region; immune response; polysaccharide binding; proteolysis; scavenger receptor activity IPR025661; IPR025660; IPR013128; IPR000668; IPR001212; Uncharacterized peptidase C1-like protein F26E4.3 F26E4.3 Caenorhabditis elegans TR39046_c3_g1_i2 Q9GZM7 TINAL_HUMAN 6.00E-108 GO:0008234; GO:0005737; GO:0016197; GO:0005201; GO:0005615; GO:0006955; GO:0030247; GO:0006508; GO:0005044 cysteine-type peptidase activity; cytoplasm; endosomal transport; extracellular matrix structural constituent; extracellular space; immune response; polysaccharide binding; proteolysis; scavenger receptor activity IPR025660; IPR013128; IPR000668; IPR001212; Tubulointerstitial nephritis antigen-like (Glucocorticoid-inducible protein 5) (Oxidized LDL-responsive gene 2 protein) (OLRG-2) (Tubulointerstitial nephritis antigen-related protein) (TIN Ag-related protein) (TIN-Ag-RP) TINAGL1 GIS5 LCN7 OLRG2 TINAGL PP6614 PSEC0088 UNQ204/PRO230 Homo sapiens (Human) TR39046_c3_g1_i3 Q99JR5 TINAL_MOUSE 1.00E-46 GO:0008234; GO:0005737; GO:0031012; GO:0005576; GO:0006955; GO:0030247; GO:0006508; GO:0005044 cysteine-type peptidase activity; cytoplasm; extracellular matrix; extracellular region; immune response; polysaccharide binding; proteolysis; scavenger receptor activity IPR025660; IPR013128; IPR000668; IPR001212; Tubulointerstitial nephritis antigen-like (Adrenocortical zonation factor 1) (AZ-1) (Androgen-regulated gene 1 protein) (Tubulointerstitial nephritis antigen-related protein) (TARP) Tinagl1 Arg1 Lcn7 Tinagl Mus musculus (Mouse) TR39046_c3_g2_i1 P43507 CPR3_CAEEL 9.00E-11 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; Cathepsin B-like cysteine proteinase 3 (EC 3.4.22.-) (Cysteine protease-related 3) cpr-3 T10H4.12 Caenorhabditis elegans TR39047_c1_g3_i4 P86221 TBB4B_MESAU 9.00E-54 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR013838; IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta-4B chain (Tubulin beta-2C chain) (Fragments) TUBB4B TUBB2C Mesocricetus auratus (Golden hamster) TR39047_c1_g3_i5 Q9UJT0 TBE_HUMAN 2.00E-06 GO:0005525; GO:0003924; GO:0007098; GO:0005874; GO:0000242; GO:0051258; GO:0005200 GTP binding; GTPase activity; centrosome cycle; microtubule; pericentriolar material; protein polymerization; structural constituent of cytoskeleton IPR004057; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin epsilon chain (Epsilon-tubulin) TUBE1 TUBE Homo sapiens (Human) TR39047_c1_g3_i6 P32882 TBB2_CHICK 1.00E-70 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR013838; IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta-2 chain (Beta-tubulin class-II) Gallus gallus (Chicken) TR39047_c1_g3_i8 P25862 TBB1_AVESA 2.00E-25 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta-1 chain (Beta-1-tubulin) (Fragment) TUBB1 TUB1 Avena sativa (Oat) TR39047_c1_g5_i2 P50260 TBB2_OOMCK 6.00E-48 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta-2 chain (Beta-2-tubulin) (Fragment) TUBB2 Oomycete-like sp. (strain MacKay2000) TR3905_c0_g1_i1 Q86V42 F124A_HUMAN 2.00E-10 Protein FAM124A FAM124A Homo sapiens (Human) TR39051_c2_g1_i2 Q9JI59 JAM2_MOUSE 7.00E-08 GO:0016021; GO:0007162; GO:0005886; GO:0005923 integral to membrane; negative regulation of cell adhesion; plasma membrane; tight junction IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Junctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322) Jam2 Vejam Mus musculus (Mouse) TR39051_c2_g1_i4 Q9JI59 JAM2_MOUSE 1.00E-07 GO:0016021; GO:0007162; GO:0005886; GO:0005923 integral to membrane; negative regulation of cell adhesion; plasma membrane; tight junction IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Junctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322) Jam2 Vejam Mus musculus (Mouse) TR39052_c1_g1_i1 Q923L3 CSMD1_MOUSE 3.00E-14 GO:0016021 integral to membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 1 (CUB and sushi multiple domains protein 1) Csmd1 Mus musculus (Mouse) TR39052_c1_g2_i1 P98065 TSG6_RABIT 3.00E-11 GO:0007155; GO:0005540 cell adhesion; hyaluronic acid binding IPR016186; IPR016187; IPR000859; IPR000538; Tumor necrosis factor-inducible gene 6 protein (Hyaluronate-binding protein PS4) (TNF-stimulated gene 6 protein) (TSG-6) (Tumor necrosis factor alpha-induced protein 6) (TNF alpha-induced protein 6) TNFAIP6 PS4 TSG6 Oryctolagus cuniculus (Rabbit) TR39053_c1_g1_i3 Q80UU2 RPP38_MOUSE 3.00E-11 GO:0005730; GO:0004526; GO:0008033 nucleolus; ribonuclease P activity; tRNA processing IPR004038; Ribonuclease P protein subunit p38 (RNaseP protein p38) (EC 3.1.26.5) Rpp38 Mus musculus (Mouse) TR39056_c2_g1_i1 B5FXA0 LYRM5_TAEGU 9.00E-35 IPR008011; LYR motif-containing protein 5 LYRM5 Taeniopygia guttata (Zebra finch) (Poephila guttata) TR39057_c0_g1_i1 Q78KK3 S22AI_MOUSE 1.00E-74 GO:0016324; GO:0015238; GO:0005887; GO:0005635; GO:0008514; GO:0015293 apical plasma membrane; drug transmembrane transporter activity; integral to plasma membrane; nuclear envelope; organic anion transmembrane transporter activity; symporter activity IPR011701; IPR020846; IPR016196; IPR001958; Solute carrier family 22 member 18 (Imprinted multi-membrane-spanning polyspecific transporter-related protein 1) (Multi-membrane-spanning polyspecific transporter) (Organic cation transporter-like protein 2) (ORCTL-2) Slc22a18 Impt1 Itm Orctl2 Tssc5 Mus musculus (Mouse) TR39057_c0_g1_i3 Q78KK3 S22AI_MOUSE 1.00E-51 GO:0016324; GO:0015238; GO:0005887; GO:0005635; GO:0008514; GO:0015293 apical plasma membrane; drug transmembrane transporter activity; integral to plasma membrane; nuclear envelope; organic anion transmembrane transporter activity; symporter activity IPR011701; IPR020846; IPR016196; IPR001958; Solute carrier family 22 member 18 (Imprinted multi-membrane-spanning polyspecific transporter-related protein 1) (Multi-membrane-spanning polyspecific transporter) (Organic cation transporter-like protein 2) (ORCTL-2) Slc22a18 Impt1 Itm Orctl2 Tssc5 Mus musculus (Mouse) TR39058_c0_g2_i1 B5DG51 MCMBP_SALSA 2.00E-91 GO:0006261; GO:0051301; GO:0003682; GO:0007067; GO:0000084; GO:0005634; GO:0007062 DNA-dependent DNA replication; cell division; chromatin binding; mitosis; mitotic S phase; nucleus; sister chromatid cohesion IPR019140; Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) mcmbp Salmo salar (Atlantic salmon) TR39058_c0_g2_i3 Q28DV7 MCMBP_XENTR 2.00E-94 GO:0006261; GO:0051301; GO:0003682; GO:0007067; GO:0000084; GO:0005634; GO:0007062 DNA-dependent DNA replication; cell division; chromatin binding; mitosis; mitotic S phase; nucleus; sister chromatid cohesion IPR019140; Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) mcmbp TEgg098e22.1-001 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39059_c2_g1_i1 Q9J5H8 V023_FOWPN 8.00E-06 IPR002110; IPR020683; Putative ankyrin repeat protein FPV023 FPV023 Fowlpox virus (strain NVSL) (FPV) TR39059_c4_g3_i1 Q5UPG5 YL093_MIMIV 4.00E-17 IPR002110; IPR020683; Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) TR39059_c4_g3_i2 Q5UPJ9 YL122_MIMIV 1.00E-08 IPR002110; IPR020683; Putative ankyrin repeat protein L122 MIMI_L122 Acanthamoeba polyphaga mimivirus (APMV) TR39059_c4_g3_i3 Q9WV72 ASB3_MOUSE 2.00E-08 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 3 (ASB-3) Asb3 Mus musculus (Mouse) TR39059_c4_g3_i4 Q9H2K2 TNKS2_HUMAN 6.00E-12 GO:0000139; GO:0003950; GO:0016055; GO:0046872; GO:0035264; GO:0000784; GO:0005635; GO:0000242; GO:0048471; GO:0090263; GO:0032212; GO:0070213; GO:0070198; GO:0000209; GO:0040014 O15084; O15169; Q9NWV8; P11274; Q6V0I7; Q9NWT6; Q92698; P78314; Q06649; O43815; P54274 "Golgi membrane; NAD+ ADP-ribosyltransferase activity; Wnt receptor signaling pathway; metal ion binding; multicellular organism growth; nuclear chromosome, telomeric region; nuclear envelope; pericentriolar material; perinuclear region of cytoplasm; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of telomere maintenance via telomerase; protein auto-ADP-ribosylation; protein localization to chromosome, telomeric region; protein polyubiquitination; regulation of multicellular organism growth" IPR002110; IPR020683; IPR012317; IPR001660; IPR013761; IPR011510; Tankyrase-2 (TANK2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-like protein) (Tankyrase-related protein) TNKS2 PARP5B TANK2 TNKL Homo sapiens (Human) TR39059_c4_g3_i5 Q4UMH6 Y381_RICFE 4.00E-18 GO:0015969 guanosine tetraphosphate metabolic process IPR002110; IPR020683; IPR007685; Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR39060_c3_g1_i4 Q8TDB6 DTX3L_HUMAN 3.00E-46 GO:0005737; GO:0006302; GO:0042393; GO:0010390; GO:0005634; GO:0004842; GO:0008270 cytoplasm; double-strand break repair; histone binding; histone monoubiquitination; nucleus; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) TR39062_c1_g1_i1 O15050 TRNK1_HUMAN 2.00E-12 GO:0005524; GO:0016787 ATP binding; hydrolase activity IPR002110; IPR020683; IPR014017; IPR027417; IPR013026; IPR011990; IPR014016; TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) TR39067_c1_g1_i1 P70372 ELAV1_MOUSE 1.00E-15 GO:0070935; GO:0005737; GO:0003725; GO:0035925; GO:0000166; GO:0005634; GO:0045727 Q03160; Q80ZW7 3'-UTR-mediated mRNA stabilization; cytoplasm; double-stranded RNA binding; mRNA 3'-UTR AU-rich region binding; nucleotide binding; nucleus; positive regulation of translation IPR006548; IPR002343; IPR012677; IPR000504; ELAV-like protein 1 (Elav-like generic protein) (Hu-antigen R) (HuR) (MelG) Elavl1 Elra Hua Mus musculus (Mouse) TR39067_c1_g1_i2 Q15427 SF3B4_HUMAN 3.00E-140 GO:0003723; GO:0005689; GO:0000398; GO:0005654; GO:0000166 O75934; Q15029; P62993; Q6P2Q9; P98175; Q13435; Q9BRX9 "RNA binding; U12-type spliceosomal complex; mRNA splicing, via spliceosome; nucleoplasm; nucleotide binding" IPR012677; IPR000504; Splicing factor 3B subunit 4 (Pre-mRNA-splicing factor SF3b 49 kDa subunit) (SF3b50) (Spliceosome-associated protein 49) (SAP 49) SF3B4 SAP49 Homo sapiens (Human) TR39068_c0_g1_i1 Q9NWY4 CD027_HUMAN 2.00E-104 GO:0005634 nucleus IPR019361; UPF0609 protein C4orf27 C4orf27 Homo sapiens (Human) TR39069_c1_g1_i1 Q5PPJ2 RSRC1_RAT 4.00E-08 GO:0005737; GO:0000398; GO:0016607; GO:0006913 "cytoplasm; mRNA splicing, via spliceosome; nuclear speck; nucleocytoplasmic transport" Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1) Rsrc1 Srrp53 Rattus norvegicus (Rat) TR39069_c2_g2_i1 O19021 SP17_MACFA 1.00E-21 GO:0007339; GO:0016020 binding of sperm to zona pellucida; membrane IPR003117; IPR000048; IPR012105; Sperm surface protein Sp17 (Sperm autoantigenic protein 17) SPA17 SP17 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR39071_c0_g1_i1 Q9QXV8 SPY2_MOUSE 4.00E-19 GO:0060449; GO:0045165; GO:0005737; GO:0000132; GO:0042472; GO:0060437; GO:0005874; GO:0070373; GO:0043407; GO:0034261; GO:0046580; GO:0043066; GO:0008285; GO:0040037; GO:0051387; GO:0010801; GO:0070374; GO:0010628; GO:0033138; GO:0051897; GO:0043539; GO:0032587; GO:0007605 bud elongation involved in lung branching; cell fate commitment; cytoplasm; establishment of mitotic spindle orientation; inner ear morphogenesis; lung growth; microtubule; negative regulation of ERK1 and ERK2 cascade; negative regulation of MAP kinase activity; negative regulation of Ras GTPase activity; negative regulation of Ras protein signal transduction; negative regulation of apoptotic process; negative regulation of cell proliferation; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of neurotrophin TRK receptor signaling pathway; negative regulation of peptidyl-threonine phosphorylation; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling cascade; protein serine/threonine kinase activator activity; ruffle membrane; sensory perception of sound IPR007875; Protein sprouty homolog 2 (Spry-2) Spry2 Mus musculus (Mouse) TR39074_c1_g1_i1 Q9NS39 RED2_HUMAN 8.00E-17 GO:0004000; GO:0003725; GO:0006397; GO:0046872; GO:0005739; GO:0005634; GO:0003727 adenosine deaminase activity; double-stranded RNA binding; mRNA processing; metal ion binding; mitochondrion; nucleus; single-stranded RNA binding IPR002466; IPR014720; Double-stranded RNA-specific editase B2 (EC 3.5.-.-) (RNA-dependent adenosine deaminase 3) (RNA-editing deaminase 2) (RNA-editing enzyme 2) (dsRNA adenosine deaminase B2) ADARB2 ADAR3 RED2 Homo sapiens (Human) TR39074_c1_g2_i1 Q28FE8 ADAT1_XENTR 3.00E-59 GO:0003723; GO:0046872; GO:0008033; GO:0008251 RNA binding; metal ion binding; tRNA processing; tRNA-specific adenosine deaminase activity IPR002466; tRNA-specific adenosine deaminase 1 (EC 3.5.4.34) (tRNA-specific adenosine-37 deaminase) adat1 TEgg036c08.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39075_c0_g2_i1 Q64311 NTAN1_MOUSE 5.00E-74 GO:0008344; GO:0005737; GO:0007613; GO:0005634; GO:0008418 adult locomotory behavior; cytoplasm; memory; nucleus; protein-N-terminal asparagine amidohydrolase activity IPR026750; Protein N-terminal asparagine amidohydrolase (EC 3.5.1.-) (Protein NH2-terminal asparagine amidohydrolase) (PNAA) (Protein NH2-terminal asparagine deamidase) (PNAD) (Protein N-terminal Asn amidase) (Protein NTN-amidase) Ntan1 Mus musculus (Mouse) TR39076_c0_g3_i1 P45843 SCRT_DROME 9.00E-15 GO:0005524; GO:0006200; GO:0016887; GO:0006856; GO:0016021; GO:0006727; GO:0031409 ATP binding; ATP catabolic process; ATPase activity; eye pigment precursor transport; integral to membrane; ommochrome biosynthetic process; pigment binding IPR003593; IPR013525; IPR003439; IPR017871; IPR027417; IPR005284; Protein scarlet st CG4314 Drosophila melanogaster (Fruit fly) TR39076_c0_g3_i2 Q9H222 ABCG5_HUMAN 5.00E-59 GO:0005524; GO:0006200; GO:0016887; GO:0016324; GO:0033344; GO:0042632; GO:0017127; GO:0007588; GO:0016021; GO:0030299; GO:0045796; GO:0010949; GO:0042493; GO:0010212; GO:0007584; GO:0055085 Q9H221; P16333 ATP binding; ATP catabolic process; ATPase activity; apical plasma membrane; cholesterol efflux; cholesterol homeostasis; cholesterol transporter activity; excretion; integral to membrane; intestinal cholesterol absorption; negative regulation of intestinal cholesterol absorption; negative regulation of intestinal phytosterol absorption; response to drug; response to ionizing radiation; response to nutrient; transmembrane transport IPR003593; IPR013525; IPR003439; IPR027417; ATP-binding cassette sub-family G member 5 (Sterolin-1) ABCG5 Homo sapiens (Human) TR39077_c1_g1_i1 Q5C9Z4 NOM1_HUMAN 3.00E-147 GO:0003723; GO:0005730 RNA binding; nucleolus IPR016024; IPR003891; IPR016021; IPR003890; Nucleolar MIF4G domain-containing protein 1 (SGD1 homolog) NOM1 C7orf3 Homo sapiens (Human) TR39078_c1_g1_i1 Q96BZ8 LENG1_HUMAN 2.00E-07 IPR019339; Leukocyte receptor cluster member 1 LENG1 Homo sapiens (Human) TR39078_c1_g1_i2 Q3T0Z5 LENG1_BOVIN 2.00E-08 IPR019339; Leukocyte receptor cluster member 1 homolog LENG1 Bos taurus (Bovine) TR39078_c1_g3_i1 Q8AVD3 KAD2_XENLA 9.00E-112 GO:0005524; GO:0004017; GO:0005758 ATP binding; adenylate kinase activity; mitochondrial intermembrane space IPR006259; IPR000850; IPR007862; IPR027417; "Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase)" ak2 Xenopus laevis (African clawed frog) TR39078_c1_g3_i11 Q5REI7 KAD2_PONAB 2.00E-114 GO:0005524; GO:0004017; GO:0005743; GO:0005758; GO:0097226 ATP binding; adenylate kinase activity; mitochondrial inner membrane; mitochondrial intermembrane space; sperm mitochondrial sheath IPR006259; IPR000850; IPR007862; IPR027417; "Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed]" AK2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39078_c1_g3_i12 P29410 KAD2_RAT 4.00E-19 GO:0006172; GO:0046033; GO:0005524; GO:0046034; GO:0046083; GO:0004017; GO:0007420; GO:0005829; GO:0046060; GO:0001889; GO:0005743; GO:0005758; GO:0006119; GO:0097066; GO:0097226 ADP biosynthetic process; AMP metabolic process; ATP binding; ATP metabolic process; adenine metabolic process; adenylate kinase activity; brain development; cytosol; dATP metabolic process; liver development; mitochondrial inner membrane; mitochondrial intermembrane space; oxidative phosphorylation; response to thyroid hormone stimulus; sperm mitochondrial sheath IPR006259; IPR000850; IPR007862; IPR027417; "Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed]" Ak2 Rattus norvegicus (Rat) TR39079_c0_g2_i1 P10394 POL4_DROME 4.00E-21 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR39079_c2_g1_i2 Q09575 YRD6_CAEEL 7.00E-44 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR39079_c2_g1_i3 P07572 POL_MPMV 3.00E-12 GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0075713; GO:0090305; GO:0004523; GO:0046718; GO:0008270 DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; establishment of integrated proviral latency; nucleic acid phosphodiester bond hydrolysis; ribonuclease H activity; viral entry into host cell; zinc ion binding IPR001037; IPR001584; IPR017856; IPR003308; IPR012337; IPR002156; IPR000477; IPR010661; Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN)] pol Mason-Pfizer monkey virus (MPMV) (Simian Mason-Pfizer virus) TR39079_c3_g1_i1 P92523 M860_ARATH 2.00E-11 GO:0005739 mitochondrion Uncharacterized mitochondrial protein AtMg00860 (ORF158) AtMg00860 Arabidopsis thaliana (Mouse-ear cress) TR39080_c0_g3_i2 Q9R0J8 LGMN_RAT 3.00E-118 GO:0004197; GO:0005764; GO:1901185; GO:0051603; GO:0032801; GO:0003014 cysteine-type endopeptidase activity; lysosome; negative regulation of ERBB signaling pathway; proteolysis involved in cellular protein catabolic process; receptor catabolic process; renal system process IPR001096; "Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1)" Lgmn Prsc1 Rattus norvegicus (Rat) TR39081_c2_g2_i1 Q04791 SASB_ANAPL 2.00E-81 GO:0006633; GO:0016787 fatty acid biosynthetic process; hydrolase activity IPR002018; IPR019826; IPR019819; "Fatty acyl-CoA hydrolase precursor, medium chain (EC 3.1.2.-) (Thioesterase B)" Anas platyrhynchos (Domestic duck) (Anas boschas) TR39083_c0_g1_i2 O54715 VAS1_RAT 5.00E-24 GO:0005524; GO:0015991; GO:0007568; GO:0008219; GO:0016021; GO:0046933; GO:0046961; GO:0033180; GO:0005774 "ATP binding; ATP hydrolysis coupled proton transport; aging; cell death; integral to membrane; proton-transporting ATP synthase activity, rotational mechanism; proton-transporting ATPase activity, rotational mechanism; proton-transporting V-type ATPase, V1 domain; vacuolar membrane" IPR008388; IPR024722; V-type proton ATPase subunit S1 (V-ATPase subunit S1) (C7-1 protein) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1) Atp6ap1 Atp6ip1 Atp6s1 Rattus norvegicus (Rat) TR39085_c0_g1_i3 P15588 G6PD_DIDVI 1.00E-18 GO:0050661; GO:0006739; GO:0051156; GO:0004345; GO:0006098 NADP binding; NADP metabolic process; glucose 6-phosphate metabolic process; glucose-6-phosphate dehydrogenase activity; pentose-phosphate shunt IPR001282; IPR022675; IPR022674; IPR016040; Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) (Fragments) G6PD Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) TR39085_c0_g3_i1 O55044 G6PD_CRIGR 0 GO:0050661; GO:0006739; GO:0051156; GO:0004345; GO:0006098 NADP binding; NADP metabolic process; glucose 6-phosphate metabolic process; glucose-6-phosphate dehydrogenase activity; pentose-phosphate shunt IPR001282; IPR019796; IPR022675; IPR022674; IPR016040; Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) G6PD Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR39085_c0_g3_i2 O55044 G6PD_CRIGR 0 GO:0050661; GO:0006739; GO:0051156; GO:0004345; GO:0006098 NADP binding; NADP metabolic process; glucose 6-phosphate metabolic process; glucose-6-phosphate dehydrogenase activity; pentose-phosphate shunt IPR001282; IPR019796; IPR022675; IPR022674; IPR016040; Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) G6PD Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR39086_c0_g1_i1 Q3UHX0 NOL8_MOUSE 1.00E-21 GO:0006260; GO:0003723; GO:0005730; GO:0000166; GO:0030307; GO:0006364 DNA replication; RNA binding; nucleolus; nucleotide binding; positive regulation of cell growth; rRNA processing IPR012677; IPR000504; Nucleolar protein 8 Nol8 Mus musculus (Mouse) TR39086_c0_g2_i2 Q9VWD4 Y4230_DROME 2.00E-07 GO:0003729; GO:0022008; GO:0000166 mRNA binding; neurogenesis; nucleotide binding IPR012677; IPR000504; Probable RNA-binding protein CG14230 CG14230 Drosophila melanogaster (Fruit fly) TR39086_c0_g2_i5 Q3UHX0 NOL8_MOUSE 5.00E-11 GO:0006260; GO:0003723; GO:0005730; GO:0000166; GO:0030307; GO:0006364 DNA replication; RNA binding; nucleolus; nucleotide binding; positive regulation of cell growth; rRNA processing IPR012677; IPR000504; Nucleolar protein 8 Nol8 Mus musculus (Mouse) TR39091_c4_g1_i2 P59016 VP33B_MOUSE 5.00E-153 GO:0030897; GO:0031902; GO:0005765; GO:0032418; GO:0032400; GO:0048471; GO:0031091; GO:0070889; GO:0015031; GO:0006904; GO:0016192 P62492 HOPS complex; late endosome membrane; lysosomal membrane; lysosome localization; melanosome localization; perinuclear region of cytoplasm; platelet alpha granule; platelet alpha granule organization; protein transport; vesicle docking involved in exocytosis; vesicle-mediated transport IPR027482; IPR001619; IPR027121; Vacuolar protein sorting-associated protein 33B Vps33b Mus musculus (Mouse) TR39092_c1_g1_i2 P21265 PUR8_CHICK 0 GO:0044208; GO:0006189; GO:0070626; GO:0006167; GO:0004018; GO:0005829; GO:0006144 "'de novo' AMP biosynthetic process; 'de novo' IMP biosynthetic process; (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity; AMP biosynthetic process; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; cytosol; purine nucleobase metabolic process" IPR019468; IPR024083; IPR020557; IPR000362; IPR022761; IPR008948; IPR004769; Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2. Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2. Adenylosuccinate lyase (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) ADSL Gallus gallus (Chicken) TR39092_c1_g1_i5 P44797 PUR8_HAEIN 4.00E-08 GO:0044208; GO:0006189; GO:0070626; GO:0004018 "'de novo' AMP biosynthetic process; 'de novo' IMP biosynthetic process; (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity" IPR013539; IPR024083; IPR020557; IPR000362; IPR022761; IPR008948; IPR004769; Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2. Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2. Adenylosuccinate lyase (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) purB HI_0639 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) TR39092_c1_g1_i6 P54822 PUR8_MOUSE 0 GO:0044208; GO:0006189; GO:0070626; GO:0006167; GO:0004018; GO:0005739; GO:0051262 "'de novo' AMP biosynthetic process; 'de novo' IMP biosynthetic process; (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity; AMP biosynthetic process; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; mitochondrion; protein tetramerization" IPR019468; IPR024083; IPR020557; IPR000362; IPR022761; IPR008948; IPR004769; Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2. Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2. Adenylosuccinate lyase (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) Adsl Adl Mus musculus (Mouse) TR39092_c1_g1_i7 Q59092 PCAB_ACIAD 4.00E-14 GO:0047472; GO:0042952; GO:0019619 "3-carboxy-cis,cis-muconate cycloisomerase activity; beta-ketoadipate pathway; protocatechuate catabolic process" IPR019468; IPR024083; IPR020557; IPR000362; IPR022761; IPR008948; IPR012789; "Aromatic compound metabolism; beta-ketoadipate pathway; 5-oxo-4,5-dihydro-2-furylacetate from 3-carboxy-cis,cis-muconate: step 1/2." "3-carboxy-cis,cis-muconate cycloisomerase (EC 5.5.1.2) (3-carboxymuconate lactonizing enzyme) (CMLE)" pcaB ACIAD1707 Acinetobacter sp. (strain ADP1) TR39094_c2_g1_i2 Q6PFR5 TRA2A_MOUSE 1.00E-50 GO:0003723; GO:0008380; GO:0006397; GO:0000166; GO:0005634 Itself; Q9D1X0; Q8BL97 RNA binding; RNA splicing; mRNA processing; nucleotide binding; nucleus IPR012677; IPR000504; Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) Tra2a Mus musculus (Mouse) TR39096_c0_g1_i1 O02772 FABPH_PIG 7.00E-12 GO:0005737; GO:0008289; GO:0005215 cytoplasm; lipid binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; "Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP)" FABP3 Sus scrofa (Pig) TR39096_c0_g1_i10 O02772 FABPH_PIG 7.00E-14 GO:0005737; GO:0008289; GO:0005215 cytoplasm; lipid binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; "Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP)" FABP3 Sus scrofa (Pig) TR39096_c0_g1_i8 P29373 RABP2_HUMAN 4.00E-10 GO:0005737; GO:0035115; GO:0005783; GO:0008544; GO:0005634; GO:0006355; GO:0016918; GO:0001972; GO:0042573; GO:0005501; GO:0019841; GO:0007165; GO:0005215 "cytoplasm; embryonic forelimb morphogenesis; endoplasmic reticulum; epidermis development; nucleus; regulation of transcription, DNA-dependent; retinal binding; retinoic acid binding; retinoic acid metabolic process; retinoid binding; retinol binding; signal transduction; transporter activity" IPR012674; IPR011038; IPR000463; IPR000566; Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II) CRABP2 Homo sapiens (Human) TR39097_c2_g2_i1 Q99JW2 ACY1_MOUSE 8.00E-166 GO:0004046; GO:0006520; GO:0005737; GO:0046872; GO:0008237; GO:0006508 aminoacylase activity; cellular amino acid metabolic process; cytoplasm; metal ion binding; metallopeptidase activity; proteolysis IPR001261; IPR010159; IPR002933; IPR011650; Aminoacylase-1 (ACY-1) (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase) Acy1 Mus musculus (Mouse) TR39098_c0_g1_i1 Q9BUQ8 DDX23_HUMAN 0 GO:0005524; GO:0004004; GO:0005682; GO:0071013; GO:0000354; GO:0005739; GO:0003676; GO:0005654; GO:0005886 ATP binding; ATP-dependent RNA helicase activity; U5 snRNP; catalytic step 2 spliceosome; cis assembly of pre-catalytic spliceosome; mitochondrion; nucleic acid binding; nucleoplasm; plasma membrane IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD) DDX23 Homo sapiens (Human) TR39098_c0_g1_i2 A5DF03 PRP28_PICGU 2.00E-110 GO:0005524; GO:0008026; GO:0008380; GO:0005737; GO:0006397; GO:0003676; GO:0005634 ATP binding; ATP-dependent helicase activity; RNA splicing; cytoplasm; mRNA processing; nucleic acid binding; nucleus IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; Pre-mRNA-splicing ATP-dependent RNA helicase PRP28 (EC 3.6.4.13) PRP28 PGUG_01854 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) TR39098_c0_g1_i3 Q9BUQ8 DDX23_HUMAN 0 GO:0005524; GO:0004004; GO:0005682; GO:0071013; GO:0000354; GO:0005739; GO:0003676; GO:0005654; GO:0005886 ATP binding; ATP-dependent RNA helicase activity; U5 snRNP; catalytic step 2 spliceosome; cis assembly of pre-catalytic spliceosome; mitochondrion; nucleic acid binding; nucleoplasm; plasma membrane IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD) DDX23 Homo sapiens (Human) TR39098_c0_g1_i4 Q0CLX0 PRP28_ASPTN 0 GO:0005524; GO:0008026; GO:0008380; GO:0005737; GO:0006397; GO:0003676; GO:0005634 ATP binding; ATP-dependent helicase activity; RNA splicing; cytoplasm; mRNA processing; nucleic acid binding; nucleus IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Pre-mRNA-splicing ATP-dependent RNA helicase prp28 (EC 3.6.4.13) prp28 ATEG_05314 Aspergillus terreus (strain NIH 2624 / FGSC A1156) TR39099_c5_g4_i1 P85190 FTSH_HELAN 8.00E-25 GO:0005524; GO:0009535; GO:0046872; GO:0004222; GO:0006508 ATP binding; chloroplast thylakoid membrane; metal ion binding; metalloendopeptidase activity; proteolysis IPR003959; IPR003960; IPR027417; IPR000642; "ATP-dependent zinc metalloprotease FTSH, chloroplastic (EC 3.4.24.-) (Fragment)" FTSH Helianthus annuus (Common sunflower) TR39099_c5_g5_i1 Q4R7L3 PRS6B_MACFA 0 GO:0005524; GO:0005737; GO:0017111; GO:0005634; GO:0022624; GO:0030163 ATP binding; cytoplasm; nucleoside-triphosphatase activity; nucleus; proteasome accessory complex; protein catabolic process IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (Proteasome 26S subunit ATPase 4) PSMC4 QtsA-14940 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR39099_c6_g1_i4 Q6AZB8 HARB1_DANRE 1.00E-38 GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) TR39100_c4_g2_i1 Q9BXJ4 C1QT3_HUMAN 6.00E-06 GO:0035356; GO:0005581; GO:0005615; GO:0045444; GO:0042593; GO:0042347; GO:0010629; GO:0045721; GO:0050728; GO:1900165; GO:0071638; GO:0070374; GO:0070165; GO:0050715; GO:0051897; GO:0070206 cellular triglyceride homeostasis; collagen; extracellular space; fat cell differentiation; glucose homeostasis; negative regulation of NF-kappaB import into nucleus; negative regulation of gene expression; negative regulation of gluconeogenesis; negative regulation of inflammatory response; negative regulation of interleukin-6 secretion; negative regulation of monocyte chemotactic protein-1 production; positive regulation of ERK1 and ERK2 cascade; positive regulation of adiponectin secretion; positive regulation of cytokine secretion; positive regulation of protein kinase B signaling cascade; protein trimerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) TR39100_c4_g2_i2 Q5RJ80 CAPR2_DANRE 6.00E-06 GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:2000055; GO:0090263; GO:0050775; GO:0061003; GO:0040008 RNA binding; cytoplasm; dorsal/ventral pattern formation; negative regulation of translation; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of dendrite morphogenesis; positive regulation of dendritic spine morphogenesis; regulation of growth IPR001073; IPR008983; Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR39102_c2_g1_i1 Q03QS9 DPO3_LACBA 1.00E-06 GO:0008408; GO:0003677; GO:0006260; GO:0003887; GO:0005737; GO:0090305 3'-5' exonuclease activity; DNA binding; DNA replication; DNA-directed DNA polymerase activity; cytoplasm; nucleic acid phosphodiester bond hydrolysis IPR011708; IPR028112; IPR024754; IPR006054; IPR006055; IPR013520; IPR012340; IPR004365; IPR004013; IPR003141; IPR006308; IPR012337; DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC LVIS_1341 Lactobacillus brevis (strain ATCC 367 / JCM 1170) TR39102_c2_g1_i2 Q03QS9 DPO3_LACBA 7.00E-07 GO:0008408; GO:0003677; GO:0006260; GO:0003887; GO:0005737; GO:0090305 3'-5' exonuclease activity; DNA binding; DNA replication; DNA-directed DNA polymerase activity; cytoplasm; nucleic acid phosphodiester bond hydrolysis IPR011708; IPR028112; IPR024754; IPR006054; IPR006055; IPR013520; IPR012340; IPR004365; IPR004013; IPR003141; IPR006308; IPR012337; DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC LVIS_1341 Lactobacillus brevis (strain ATCC 367 / JCM 1170) TR39102_c3_g1_i1 Q3ZBG9 PLS2_BOVIN 2.00E-87 GO:0016021; GO:0046872 integral to membrane; metal ion binding IPR005552; Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) TR39102_c3_g1_i4 Q3ZBG9 PLS2_BOVIN 2.00E-87 GO:0016021; GO:0046872 integral to membrane; metal ion binding IPR005552; Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) TR39103_c0_g1_i1 Q2TBP7 MYCBP_BOVIN 3.00E-37 GO:0005813; GO:0005737; GO:0005634; GO:0006355; GO:0007283; GO:0003713; GO:0006351 "centrosome; cytoplasm; nucleus; regulation of transcription, DNA-dependent; spermatogenesis; transcription coactivator activity; transcription, DNA-dependent" IPR026060; C-Myc-binding protein (Associate of Myc 1) (AMY-1) MYCBP AMY1 Bos taurus (Bovine) TR39105_c0_g1_i1 Q9CQ29 RN151_MOUSE 5.00E-19 GO:0030154; GO:0005737; GO:0005634; GO:0007283; GO:0004842; GO:0008270 cell differentiation; cytoplasm; nucleus; spermatogenesis; ubiquitin-protein ligase activity; zinc ion binding IPR013323; IPR008974; IPR001841; IPR013083; IPR017907; IPR013010; IPR001293; RING finger protein 151 Rnf151 Mus musculus (Mouse) TR39105_c0_g1_i2 Q8BH75 RNF41_MOUSE 5.00E-163 GO:0005128; GO:0097191; GO:0005135; GO:0030336; GO:0008285; GO:0000209; GO:0031386; GO:0043408; GO:0045619; GO:0045637; GO:0051896; GO:2000377; GO:0004842; GO:0008270 erythropoietin receptor binding; extrinsic apoptotic signaling pathway; interleukin-3 receptor binding; negative regulation of cell migration; negative regulation of cell proliferation; protein polyubiquitination; protein tag; regulation of MAPK cascade; regulation of lymphocyte differentiation; regulation of myeloid cell differentiation; regulation of protein kinase B signaling cascade; regulation of reactive oxygen species metabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR013323; IPR008974; IPR015036; IPR018957; IPR001841; IPR013083; IPR017907; IPR013010; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase NRDP1 (EC 6.3.2.-) (RING finger protein 41) Rnf41 Flrf Nrdp1 Mus musculus (Mouse) TR39106_c2_g1_i2 O43301 HS12A_HUMAN 6.00E-62 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR39106_c2_g1_i3 O43301 HS12A_HUMAN 8.00E-62 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR39108_c2_g1_i1 Q9D0S9 HINT2_MOUSE 3.00E-57 GO:0006915; GO:0016787; GO:0005739; GO:0000166; GO:0006694 apoptotic process; hydrolase activity; mitochondrion; nucleotide binding; steroid biosynthetic process IPR019808; IPR001310; IPR011146; "Histidine triad nucleotide-binding protein 2, mitochondrial (HINT-2) (EC 3.-.-.-) (HINT-3)" Hint2 Mus musculus (Mouse) TR39108_c3_g1_i1 P05932 CALMB_ARBPU 2.00E-22 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-beta (Cam B) (Fragment) Arbacia punctulata (Punctuate sea urchin) TR39108_c3_g1_i2 Q9BLG0 TNNC_TODPA 6.00E-51 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Troponin C (TN-C) Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus) TR39109_c1_g1_i1 Q02445 TFPI1_RAT 4.00E-14 GO:0007596; GO:0005615; GO:0030414; GO:0004867 blood coagulation; extracellular space; peptidase inhibitor activity; serine-type endopeptidase inhibitor activity IPR002223; IPR008296; IPR020901; Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI) Tfpi Rattus norvegicus (Rat) TR39109_c1_g1_i2 D2Y488 CU91A_CONCL 7.00E-13 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; Conotoxin Cal9.1a Conus californicus (California cone) TR39109_c1_g1_i3 Q28864 TFPI1_MACMU 2.00E-12 GO:0007596; GO:0005615; GO:0004867 blood coagulation; extracellular space; serine-type endopeptidase inhibitor activity IPR002223; IPR008296; IPR020901; Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI) TFPI TFPI1 Macaca mulatta (Rhesus macaque) TR39110_c1_g1_i1 Q4L235 ACSF4_HUMAN 6.00E-92 GO:0005524; GO:0016878; GO:0006631 ATP binding; acid-thiol ligase activity; fatty acid metabolic process IPR009081; IPR020845; IPR000873; IPR018391; IPR027295; IPR011047; Acyl-CoA synthetase family member 4 (EC 6.2.1.-) (Aminoadipate-semialdehyde dehydrogenase) (Protein NRPS998) AASDH ACSF4 U26 HSPC318 Homo sapiens (Human) TR39110_c2_g1_i1 F4K1G2 AEE19_ARATH 3.00E-38 GO:0003824 catalytic activity IPR009081; IPR025110; IPR020845; IPR000873; IPR006162; IPR018391; IPR027295; IPR011047; Putative acyl-activating enzyme 19 At5g35930 F14A1.10 Arabidopsis thaliana (Mouse-ear cress) TR39110_c2_g1_i2 Q4L235 ACSF4_HUMAN 4.00E-70 GO:0005524; GO:0016878; GO:0006631 ATP binding; acid-thiol ligase activity; fatty acid metabolic process IPR009081; IPR020845; IPR000873; IPR018391; IPR027295; IPR011047; Acyl-CoA synthetase family member 4 (EC 6.2.1.-) (Aminoadipate-semialdehyde dehydrogenase) (Protein NRPS998) AASDH ACSF4 U26 HSPC318 Homo sapiens (Human) TR39112_c0_g1_i1 Q9I7U4 TITIN_DROME 3.00E-08 GO:0030018; GO:0003779; GO:0051301; GO:0000794; GO:0040011; GO:0007498; GO:0005875; GO:0007076; GO:0016203; GO:0007520; GO:0035206; GO:0045214; GO:0007062; GO:0007519; GO:0007525; GO:0008307; GO:0007522 Z disc; actin binding; cell division; condensed nuclear chromosome; locomotion; mesoderm development; microtubule associated complex; mitotic chromosome condensation; muscle attachment; myoblast fusion; regulation of hemocyte proliferation; sarcomere organization; sister chromatid cohesion; skeletal muscle tissue development; somatic muscle development; structural constituent of muscle; visceral muscle development IPR010939; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR001452; Titin (D-Titin) (Kettin) sls titin CG1915 Drosophila melanogaster (Fruit fly) TR39112_c1_g1_i1 Q15746 MYLK_HUMAN 3.00E-09 GO:0005524; GO:0060414; GO:0032060; GO:0071476; GO:0032154; GO:0005829; GO:0030027; GO:0046872; GO:0004687; GO:0005886; GO:0051928; GO:0030335; GO:0090303; GO:0001725; GO:0014820 P16333 ATP binding; aorta smooth muscle tissue morphogenesis; bleb assembly; cellular hypotonic response; cleavage furrow; cytosol; lamellipodium; metal ion binding; myosin light chain kinase activity; plasma membrane; positive regulation of calcium ion transport; positive regulation of cell migration; positive regulation of wound healing; stress fiber; tonic smooth muscle contraction IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR020675; IPR000719; IPR017441; IPR002290; IPR008271; "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]" MYLK MLCK MLCK1 MYLK1 Homo sapiens (Human) TR39113_c1_g1_i2 Q6GMR7 FAAH2_HUMAN 4.00E-165 GO:0016884; GO:0016787; GO:0016021 "carbon-nitrogen ligase activity, with glutamine as amido-N-donor; hydrolase activity; integral to membrane" IPR000120; IPR020556; IPR023631; Fatty-acid amide hydrolase 2 (EC 3.5.1.99) (Amidase domain-containing protein) (Anandamide amidohydrolase 2) (Oleamide hydrolase 2) FAAH2 AMDD Homo sapiens (Human) TR39113_c2_g1_i1 O70400 PDLI1_MOUSE 2.00E-18 GO:0005737; GO:0005856; GO:0006355; GO:0001666; GO:0003713; GO:0005667; GO:0008270 "cytoplasm; cytoskeleton; regulation of transcription, DNA-dependent; response to hypoxia; transcription coactivator activity; transcription factor complex; zinc ion binding" IPR001478; IPR001781; PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) Pdlim1 Clim1 Mus musculus (Mouse) TR39113_c2_g1_i2 P50479 PDLI4_HUMAN 2.00E-14 GO:0008270 zinc ion binding IPR001478; IPR001781; PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein) PDLIM4 RIL Homo sapiens (Human) TR39113_c2_g1_i3 Q6GLJ6 PDLI3_XENLA 7.00E-24 GO:0030018; GO:0008270 Z disc; zinc ion binding IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein 3 pdlim3 Xenopus laevis (African clawed frog) TR39113_c2_g1_i4 O70209 PDLI3_MOUSE 1.00E-22 GO:0030018; GO:0015629; GO:0007015; GO:0007507; GO:0008307; GO:0008270 Z disc; actin cytoskeleton; actin filament organization; heart development; structural constituent of muscle; zinc ion binding IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) Pdlim3 Mus musculus (Mouse) TR39113_c3_g2_i1 A2ALK8 PTN3_MOUSE 0 GO:0005737; GO:0005856; GO:0009898; GO:0051045; GO:0045930; GO:0004725 cytoplasm; cytoskeleton; internal side of plasma membrane; negative regulation of membrane protein ectodomain proteolysis; negative regulation of mitotic cell cycle; protein tyrosine phosphatase activity IPR019749; IPR019750; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR001478; IPR011993; IPR000387; IPR016130; IPR012151; IPR000242; Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) Ptpn3 Mus musculus (Mouse) TR39113_c3_g2_i2 P28191 PTP1_CAEEL 3.00E-171 GO:0005856; GO:0035335; GO:0004725; GO:0016529 cytoskeleton; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; sarcoplasmic reticulum IPR019749; IPR019750; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR001478; IPR011993; IPR000387; IPR016130; IPR012151; IPR000242; Tyrosine-protein phosphatase 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1) ptp-1 C48D5.2 Caenorhabditis elegans TR39113_c3_g2_i3 P29074 PTN4_HUMAN 0 GO:0005737; GO:0005856; GO:0009898; GO:0004726 P46108; Q92993; P16333 cytoplasm; cytoskeleton; internal side of plasma membrane; non-membrane spanning protein tyrosine phosphatase activity IPR019749; IPR019750; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR001478; IPR011993; IPR000387; IPR016130; IPR012151; IPR000242; Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1) PTPN4 Homo sapiens (Human) TR39113_c3_g2_i4 P29074 PTN4_HUMAN 0 GO:0005737; GO:0005856; GO:0009898; GO:0004726 P46108; Q92993; P16333 cytoplasm; cytoskeleton; internal side of plasma membrane; non-membrane spanning protein tyrosine phosphatase activity IPR019749; IPR019750; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR001478; IPR011993; IPR000387; IPR016130; IPR012151; IPR000242; Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1) PTPN4 Homo sapiens (Human) TR39113_c3_g2_i6 Q54EW0 FRMA_DICDI 3.00E-08 GO:0015629; GO:0030036; GO:0048870; GO:0022408; GO:0010812; GO:0046956; GO:0031288 actin cytoskeleton; actin cytoskeleton organization; cell motility; negative regulation of cell-cell adhesion; negative regulation of cell-substrate adhesion; positive phototaxis; sorocarp morphogenesis IPR019749; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR011993; FERM domain-containing protein A frmA DDB_G0291303 Dictyostelium discoideum (Slime mold) TR39113_c3_g2_i7 P28191 PTP1_CAEEL 2.00E-177 GO:0005856; GO:0035335; GO:0004725; GO:0016529 cytoskeleton; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; sarcoplasmic reticulum IPR019749; IPR019750; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR001478; IPR011993; IPR000387; IPR016130; IPR012151; IPR000242; Tyrosine-protein phosphatase 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1) ptp-1 C48D5.2 Caenorhabditis elegans TR39114_c0_g1_i1 P31692 ADT_PARKE 7.00E-21 GO:0016021; GO:0005743; GO:0055085; GO:0005215 integral to membrane; mitochondrial inner membrane; transmembrane transport; transporter activity IPR002113; IPR002067; IPR018108; IPR023395; "ADP,ATP carrier protein (ADP/ATP translocase) (Adenine nucleotide translocator) (ANT)" Parachlorella kessleri (Green alga) (Chlorella kessleri) TR39114_c0_g1_i2 Q41629 ADT1_WHEAT 6.00E-18 GO:0016021; GO:0005743; GO:0055085; GO:0005215 integral to membrane; mitochondrial inner membrane; transmembrane transport; transporter activity IPR002113; IPR002067; IPR018108; IPR023395; "ADP,ATP carrier protein 1, mitochondrial (ADP/ATP translocase 1) (Adenine nucleotide translocator 1) (ANT 1)" ANT-G1 Triticum aestivum (Wheat) TR39114_c0_g1_i3 P38702 LEU5_YEAST 7.00E-54 GO:0015228; GO:0016021; GO:0005743 coenzyme A transmembrane transporter activity; integral to membrane; mitochondrial inner membrane IPR002167; IPR002067; IPR018108; IPR023395; Mitochondrial carrier protein LEU5 LEU5 YHR002W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39114_c0_g1_i4 Q01888 GDC_BOVIN 2.00E-102 GO:0016021; GO:0005743; GO:0055085 integral to membrane; mitochondrial inner membrane; transmembrane transport IPR002167; IPR002067; IPR018108; IPR023395; Graves disease carrier protein (GDC) (Mitochondrial solute carrier protein homolog) (Solute carrier family 25 member 16) SLC25A16 GDA GDC Bos taurus (Bovine) TR39116_c0_g1_i1 O94856 NFASC_HUMAN 4.00E-35 GO:0007411; GO:0043194; GO:0045162; GO:0034113; GO:0016021; GO:0005622; GO:0042552; GO:0033268; GO:0033010; GO:0030913; GO:0033270; GO:0007422; GO:0005886; GO:0071205; GO:0002175; GO:0072661; GO:0050808 axon guidance; axon initial segment; clustering of voltage-gated sodium channels; heterotypic cell-cell adhesion; integral to membrane; intracellular; myelination; node of Ranvier; paranodal junction; paranodal junction assembly; paranode region of axon; peripheral nervous system development; plasma membrane; protein localization to juxtaparanode region of axon; protein localization to paranode region of axon; protein targeting to plasma membrane; synapse organization IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR026966; IPR026965; Neurofascin NFASC KIAA0756 Homo sapiens (Human) TR39116_c0_g2_i2 P20241 NRG_DROME 1.00E-43 GO:0008366; GO:0048675; GO:0005509; GO:0061343; GO:0048036; GO:0048813; GO:0007173; GO:0060857; GO:0008050; GO:0030175; GO:0007560; GO:0016021; GO:0016328; GO:0008049; GO:0035011; GO:0016319; GO:0021682; GO:0007158; GO:0005919; GO:0045924; GO:0035151; GO:0019991; GO:0050808; GO:0005923 "axon ensheathment; axon extension; calcium ion binding; cell adhesion involved in heart morphogenesis; central complex development; dendrite morphogenesis; epidermal growth factor receptor signaling pathway; establishment of glial blood-brain barrier; female courtship behavior; filopodium; imaginal disc morphogenesis; integral to membrane; lateral plasma membrane; male courtship behavior; melanotic encapsulation of foreign target; mushroom body development; nerve maturation; neuron cell-cell adhesion; pleated septate junction; regulation of female receptivity; regulation of tube size, open tracheal system; septate junction assembly; synapse organization; tight junction" IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013151; IPR026966; Neuroglian Nrg CG1634 Drosophila melanogaster (Fruit fly) TR39116_c4_g1_i1 P20241 NRG_DROME 7.00E-08 GO:0008366; GO:0048675; GO:0005509; GO:0061343; GO:0048036; GO:0048813; GO:0007173; GO:0060857; GO:0008050; GO:0030175; GO:0007560; GO:0016021; GO:0016328; GO:0008049; GO:0035011; GO:0016319; GO:0021682; GO:0007158; GO:0005919; GO:0045924; GO:0035151; GO:0019991; GO:0050808; GO:0005923 "axon ensheathment; axon extension; calcium ion binding; cell adhesion involved in heart morphogenesis; central complex development; dendrite morphogenesis; epidermal growth factor receptor signaling pathway; establishment of glial blood-brain barrier; female courtship behavior; filopodium; imaginal disc morphogenesis; integral to membrane; lateral plasma membrane; male courtship behavior; melanotic encapsulation of foreign target; mushroom body development; nerve maturation; neuron cell-cell adhesion; pleated septate junction; regulation of female receptivity; regulation of tube size, open tracheal system; septate junction assembly; synapse organization; tight junction" IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013151; IPR026966; Neuroglian Nrg CG1634 Drosophila melanogaster (Fruit fly) TR39117_c2_g2_i1 O15381 NVL_HUMAN 2.00E-151 GO:0005524; GO:0016235; GO:0005737; GO:0005730; GO:0017111 ATP binding; aggresome; cytoplasm; nucleolus; nucleoside-triphosphatase activity IPR003593; IPR003959; IPR003960; IPR027417; Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein) NVL Homo sapiens (Human) TR39117_c2_g3_i1 Q00568 NU3M_MYTED 1.00E-43 GO:0008137; GO:0016021; GO:0031966; GO:0070469 NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial membrane; respiratory chain IPR000440; NADH-ubiquinone oxidoreductase chain 3 (EC 1.6.5.3) (NADH dehydrogenase subunit 3) ND3 Mytilus edulis (Blue mussel) TR39117_c2_g4_i1 Q5F3X0 LCLT1_CHICK 7.00E-100 GO:0003841; GO:0016024; GO:0005789; GO:0016021; GO:0007275 1-acylglycerol-3-phosphate O-acyltransferase activity; CDP-diacylglycerol biosynthetic process; endoplasmic reticulum membrane; integral to membrane; multicellular organismal development IPR002123; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. Lysocardiolipin acyltransferase 1 (EC 2.3.1.-) (EC 2.3.1.51) LCLAT1 LYCAT RCJMB04_5b22 Gallus gallus (Chicken) TR39117_c2_g4_i2 O15381 NVL_HUMAN 7.00E-123 GO:0005524; GO:0016235; GO:0005737; GO:0005730; GO:0017111 ATP binding; aggresome; cytoplasm; nucleolus; nucleoside-triphosphatase activity IPR003593; IPR003959; IPR003960; IPR027417; Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein) NVL Homo sapiens (Human) TR39118_c1_g1_i1 O43679 LDB2_HUMAN 1.00E-169 GO:0030274; GO:0010669; GO:0001942; GO:0005634; GO:0044089; GO:0045944; GO:0035019; GO:0003712; GO:0005667 LIM domain binding; epithelial structure maintenance; hair follicle development; nucleus; positive regulation of cellular component biogenesis; positive regulation of transcription from RNA polymerase II promoter; somatic stem cell maintenance; transcription cofactor activity; transcription factor complex IPR002691; LIM domain-binding protein 2 (LDB-2) (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1) LDB2 CLIM1 Homo sapiens (Human) TR39118_c1_g1_i10 O43679 LDB2_HUMAN 2.00E-163 GO:0030274; GO:0010669; GO:0001942; GO:0005634; GO:0044089; GO:0045944; GO:0035019; GO:0003712; GO:0005667 LIM domain binding; epithelial structure maintenance; hair follicle development; nucleus; positive regulation of cellular component biogenesis; positive regulation of transcription from RNA polymerase II promoter; somatic stem cell maintenance; transcription cofactor activity; transcription factor complex IPR002691; LIM domain-binding protein 2 (LDB-2) (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1) LDB2 CLIM1 Homo sapiens (Human) TR39118_c1_g1_i2 O43679 LDB2_HUMAN 9.00E-171 GO:0030274; GO:0010669; GO:0001942; GO:0005634; GO:0044089; GO:0045944; GO:0035019; GO:0003712; GO:0005667 LIM domain binding; epithelial structure maintenance; hair follicle development; nucleus; positive regulation of cellular component biogenesis; positive regulation of transcription from RNA polymerase II promoter; somatic stem cell maintenance; transcription cofactor activity; transcription factor complex IPR002691; LIM domain-binding protein 2 (LDB-2) (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1) LDB2 CLIM1 Homo sapiens (Human) TR39118_c1_g1_i3 Q8W234 SEUSS_ARATH 1.00E-06 GO:0003677; GO:0060090; GO:0030154; GO:0009790; GO:0005634; GO:0048481; GO:0009909; GO:0006355; GO:0006351 P35631; Q9FUY2; O22456 "DNA binding; binding, bridging; cell differentiation; embryo development; nucleus; ovule development; regulation of flower development; regulation of transcription, DNA-dependent; transcription, DNA-dependent" Transcriptional corepressor SEUSS SEU At1g43850 F28H19.10 Arabidopsis thaliana (Mouse-ear cress) TR39118_c1_g1_i5 O43679 LDB2_HUMAN 2.00E-170 GO:0030274; GO:0010669; GO:0001942; GO:0005634; GO:0044089; GO:0045944; GO:0035019; GO:0003712; GO:0005667 LIM domain binding; epithelial structure maintenance; hair follicle development; nucleus; positive regulation of cellular component biogenesis; positive regulation of transcription from RNA polymerase II promoter; somatic stem cell maintenance; transcription cofactor activity; transcription factor complex IPR002691; LIM domain-binding protein 2 (LDB-2) (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1) LDB2 CLIM1 Homo sapiens (Human) TR39118_c1_g1_i7 Q1EQW7 LDB2_XENLA 3.00E-161 GO:0030274; GO:0005634; GO:0003712 LIM domain binding; nucleus; transcription cofactor activity IPR002691; LIM domain-binding protein 2 (LDB-2) (xLdb2) ldb2 Xenopus laevis (African clawed frog) TR39119_c0_g1_i1 Q9HAR2 LPHN3_HUMAN 3.00E-113 GO:0004930; GO:0030246; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; carbohydrate binding; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR001879; IPR003924; IPR015630; IPR003334; IPR000832; IPR017983; IPR000203; IPR000922; IPR003112; Latrophilin-3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Lectomedin-3) LPHN3 KIAA0768 LEC3 Homo sapiens (Human) TR39119_c0_g1_i2 O95490 LPHN2_HUMAN 1.00E-109 GO:0004930; GO:0030246; GO:0016021; GO:0016524; GO:0007218; GO:0005886 G-protein coupled receptor activity; carbohydrate binding; integral to membrane; latrotoxin receptor activity; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR001879; IPR003924; IPR003334; IPR000832; IPR017983; IPR000203; IPR000922; IPR003112; Latrophilin-2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Lectomedin-1) LPHN2 KIAA0786 LEC1 LPHH1 Homo sapiens (Human) TR39119_c0_g1_i3 P32214 CALCR_RAT 4.00E-07 GO:0007188; GO:0030424; GO:0032841; GO:0004948; GO:0016021; GO:0043025; GO:0005886 adenylate cyclase-modulating G-protein coupled receptor signaling pathway; axon; calcitonin binding; calcitonin receptor activity; integral to membrane; neuronal cell body; plasma membrane IPR003287; IPR017981; IPR001688; IPR001879; IPR000832; IPR017983; Calcitonin receptor (CT-R) (C1A/C1B) Calcr Rattus norvegicus (Rat) TR39120_c0_g1_i1 Q7Z2Z2 ETUD1_HUMAN 0 GO:0005525; GO:0003924; GO:0042256; GO:0043022; GO:0003746 GTP binding; GTPase activity; mature ribosome assembly; ribosome binding; translation elongation factor activity IPR000795; IPR009022; IPR000640; IPR027417; IPR020568; IPR014721; IPR005225; IPR009000; IPR004161; Elongation factor Tu GTP-binding domain-containing protein 1 (Elongation factor-like 1) (Protein FAM42A) EFTUD1 EFL1 FAM42A Homo sapiens (Human) TR39120_c0_g1_i2 Q7Z2Z2 ETUD1_HUMAN 0 GO:0005525; GO:0003924; GO:0042256; GO:0043022; GO:0003746 GTP binding; GTPase activity; mature ribosome assembly; ribosome binding; translation elongation factor activity IPR000795; IPR009022; IPR000640; IPR027417; IPR020568; IPR014721; IPR005225; IPR009000; IPR004161; Elongation factor Tu GTP-binding domain-containing protein 1 (Elongation factor-like 1) (Protein FAM42A) EFTUD1 EFL1 FAM42A Homo sapiens (Human) TR39120_c0_g1_i3 Q96X45 EF2_NEUCR 5.00E-72 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0045901; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; positive regulation of translational elongation; translation elongation factor activity IPR000795; IPR009022; IPR000640; IPR027417; IPR020568; IPR014721; IPR005225; IPR009000; IPR005517; IPR004161; Elongation factor 2 (EF-2) (Colonial temperature-sensitive 3) cot-3 NCU07700 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR39121_c1_g1_i1 Q80YV2 NIPA_MOUSE 7.00E-31 GO:0051301; GO:0007067; GO:2001240; GO:0031965; GO:0005634; GO:0016567; GO:0008270 cell division; mitosis; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; nuclear membrane; nucleus; protein ubiquitination; zinc ion binding IPR013909; IPR012935; Protein modification; protein ubiquitination. Nuclear-interacting partner of ALK (Nuclear-interacting partner of anaplastic lymphoma kinase) (mNIPA) (Zinc finger C3HC-type protein 1) Zc3hc1 Nipa Mus musculus (Mouse) TR39123_c2_g2_i1 Q8MKW7 RNZ_DROME 5.00E-18 GO:0016891; GO:0046331; GO:0046872; GO:0005739; GO:0022008; GO:0005634; GO:0001558; GO:0042780; GO:0006388 Q9VPY4; Q9VYC1 "endoribonuclease activity, producing 5'-phosphomonoesters; lateral inhibition; metal ion binding; mitochondrion; neurogenesis; nucleus; regulation of cell growth; tRNA 3'-end processing; tRNA splicing, via endonucleolytic cleavage and ligation" IPR001279; IPR027794; "Ribonuclease Z, mitochondrial (RNase Z) (EC 3.1.26.11) (Juvenile hormone-inducible protein 1) (dRNAse Z) (tRNA 3 endonuclease) (DmeZ) (tRNase Z)" JhI-1 CG3298 Drosophila melanogaster (Fruit fly) TR39123_c3_g1_i1 Q8HY87 RNZ2_MACFA 7.00E-105 GO:0004519; GO:0046872; GO:0072684; GO:0005739; GO:0005634 "endonuclease activity; metal ion binding; mitochondrial tRNA 3'-trailer cleavage, endonucleolytic; mitochondrion; nucleus" IPR001279; IPR027794; Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2) ELAC2 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR39123_c3_g2_i1 Q8CGS5 RNZ2_RAT 4.00E-101 GO:0004519; GO:0046872; GO:0072684; GO:0005739; GO:0005634 "endonuclease activity; metal ion binding; mitochondrial tRNA 3'-trailer cleavage, endonucleolytic; mitochondrion; nucleus" IPR001279; IPR027794; Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2) Elac2 Rattus norvegicus (Rat) TR39124_c3_g1_i1 Q64338 PDE1C_MOUSE 3.00E-70 GO:0048101; GO:0004117; GO:0005929; GO:0046872; GO:0051592; GO:0007608; GO:0007165 "calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; cilium; metal ion binding; response to calcium ion; sensory perception of smell; signal transduction" IPR003607; IPR023088; IPR002073; IPR023174; IPR013706; "Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17)" Pde1c Mus musculus (Mouse) TR39124_c3_g1_i10 Q14123 PDE1C_HUMAN 9.00E-59 GO:0007202; GO:0004117; GO:0005829; GO:0007173; GO:0008543; GO:0045087; GO:0046872; GO:0048011 activation of phospholipase C activity; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; cytosol; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; metal ion binding; neurotrophin TRK receptor signaling pathway IPR003607; IPR023088; IPR002073; IPR023174; IPR013706; "Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) (hCam-3)" PDE1C Homo sapiens (Human) TR39124_c3_g1_i7 Q64338 PDE1C_MOUSE 6.00E-167 GO:0048101; GO:0004117; GO:0005929; GO:0046872; GO:0051592; GO:0007608; GO:0007165 "calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; cilium; metal ion binding; response to calcium ion; sensory perception of smell; signal transduction" IPR003607; IPR023088; IPR002073; IPR023174; IPR013706; "Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17)" Pde1c Mus musculus (Mouse) TR39125_c0_g2_i3 P55215 CASP2_RAT 1.00E-18 GO:0006977; GO:0007568; GO:0006915; GO:0007420; GO:0071260; GO:0004197; GO:0001554; GO:0016020; GO:0005739; GO:0003407; GO:0005634; GO:0043525; GO:0016485; GO:0006508 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; aging; apoptotic process; brain development; cellular response to mechanical stimulus; cysteine-type endopeptidase activity; luteolysis; membrane; mitochondrion; neural retina development; nucleus; positive regulation of neuron apoptotic process; protein processing; proteolysis" IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] Casp2 Ich1 Rattus norvegicus (Rat) TR39127_c1_g1_i2 Q6EE31 TCPQ_CHICK 0 GO:0005524; GO:0005737; GO:0005815; GO:0006457 ATP binding; cytoplasm; microtubule organizing center; protein folding IPR012721; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) CCT8 Gallus gallus (Chicken) TR39128_c2_g1_i1 Q9I8F9 HSP71_ORYLA 1.00E-48 GO:0005524; GO:0006950 ATP binding; response to stress IPR018181; IPR013126; Heat shock 70 kDa protein 1 (HSP70-1) Oryzias latipes (Medaka fish) (Japanese ricefish) TR39128_c2_g4_i1 P39674 MAG29_DERFA 2.00E-16 GO:0005524 ATP binding IPR013126; Allergen MAG29 (Fragment) MAG29 Dermatophagoides farinae (American house dust mite) TR39128_c2_g4_i5 O97125 HSP68_DROME 4.00E-22 GO:0005524; GO:0008340; GO:0005811; GO:0005875; GO:0022008; GO:0031427; GO:0042594 ATP binding; determination of adult lifespan; lipid particle; microtubule associated complex; neurogenesis; response to methotrexate; response to starvation IPR018181; IPR013126; Heat shock protein 68 Hsp68 CG5436 Drosophila melanogaster (Fruit fly) TR39130_c2_g1_i3 Q5M7T4 YIPF4_RAT 6.00E-65 GO:0005794; GO:0016021 Golgi apparatus; integral to membrane IPR006977; Protein YIPF4 (YIP1 family member 4) Yipf4 Rattus norvegicus (Rat) TR39132_c1_g3_i1 Q2HJG4 TDRD3_BOVIN 6.00E-13 GO:0003682; GO:0016568; GO:0005737; GO:0035064; GO:0005634; GO:0003713 chromatin binding; chromatin modification; cytoplasm; methylated histone residue binding; nucleus; transcription coactivator activity IPR013894; IPR002999; IPR009060; IPR015940; IPR000449; Tudor domain-containing protein 3 TDRD3 Bos taurus (Bovine) TR39132_c2_g3_i1 Q5ZMS6 TDRD3_CHICK 2.00E-61 GO:0003723; GO:0003682; GO:0016568; GO:0005737; GO:0006397; GO:0035064; GO:0005634; GO:0003713 RNA binding; chromatin binding; chromatin modification; cytoplasm; mRNA processing; methylated histone residue binding; nucleus; transcription coactivator activity IPR013894; IPR010304; IPR002999; IPR009060; IPR015940; IPR000449; Tudor domain-containing protein 3 TDRD3 RCJMB04_1e24 Gallus gallus (Chicken) TR39134_c1_g2_i1 P84025 SMAD3_RAT 0 GO:0071141; GO:0007183; GO:0042110; GO:0097296; GO:0007050; GO:0045216; GO:0031490; GO:0000987; GO:0005737; GO:0019049; GO:0097191; GO:0006955; GO:0043066; GO:0030308; GO:0008285; GO:0050728; GO:0045930; GO:0033689; GO:0042177; GO:0001933; GO:0000122; GO:0061045; GO:0038092; GO:0005637; GO:0005634; GO:0001649; GO:0010694; GO:0030501; GO:0090263; GO:0035413; GO:0030335; GO:0032332; GO:0010718; GO:0051894; GO:1901313; GO:0032731; GO:0050927; GO:0051496; GO:0042993; GO:0045944; GO:0032916; GO:0000988; GO:0050821; GO:0043235; GO:0050776; GO:0032909; GO:0001666; GO:0003700; GO:0023019; GO:0008134; GO:0005667; GO:0006351; GO:0060290; GO:0007179; GO:0030618; GO:0006810; GO:0001657; GO:0008270 P47196 "SMAD protein complex; SMAD protein complex assembly; T cell activation; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cell cycle arrest; cell-cell junction organization; chromatin DNA binding; core promoter proximal region sequence-specific DNA binding; cytoplasm; evasion or tolerance of host defenses by virus; extrinsic apoptotic signaling pathway; immune response; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of inflammatory response; negative regulation of mitotic cell cycle; negative regulation of osteoblast proliferation; negative regulation of protein catabolic process; negative regulation of protein phosphorylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of wound healing; nodal signaling pathway; nuclear inner membrane; nucleus; osteoblast differentiation; positive regulation of alkaline phosphatase activity; positive regulation of bone mineralization; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of catenin import into nucleus; positive regulation of cell migration; positive regulation of chondrocyte differentiation; positive regulation of epithelial to mesenchymal transition; positive regulation of focal adhesion assembly; positive regulation of gene expression involved in extracellular matrix organization; positive regulation of interleukin-1 beta production; positive regulation of positive chemotaxis; positive regulation of stress fiber assembly; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor beta3 production; protein binding transcription factor activity; protein stabilization; receptor complex; regulation of immune response; regulation of transforming growth factor beta2 production; response to hypoxia; sequence-specific DNA binding transcription factor activity; signal transduction involved in regulation of gene expression; transcription factor binding; transcription factor complex; transcription, DNA-dependent; transdifferentiation; transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; transport; ureteric bud development; zinc ion binding" IPR013790; IPR003619; IPR013019; IPR017855; IPR001132; IPR008984; Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (SMAD family member 3) (SMAD 3) (Smad3) Smad3 Madh3 Rattus norvegicus (Rat) TR39134_c1_g2_i2 O70436 SMAD2_RAT 0 GO:0071141; GO:0007183; GO:0032444; GO:0009952; GO:0045165; GO:0007182; GO:0005737; GO:0003690; GO:0035556; GO:0001707; GO:0046872; GO:0008285; GO:0045892; GO:0038092; GO:0005634; GO:0060021; GO:0048340; GO:0030513; GO:0010718; GO:1900224; GO:0045944; GO:0051098; GO:0017015; GO:0070723; GO:0003700; GO:0023019; GO:0008134; GO:0005667; GO:0006351; GO:0007179; GO:0030618; GO:0001657; GO:0007352 P47196 "SMAD protein complex; SMAD protein complex assembly; activin responsive factor complex; anterior/posterior pattern specification; cell fate commitment; common-partner SMAD protein phosphorylation; cytoplasm; double-stranded DNA binding; intracellular signal transduction; mesoderm formation; metal ion binding; negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; nodal signaling pathway; nucleus; palate development; paraxial mesoderm morphogenesis; positive regulation of BMP signaling pathway; positive regulation of epithelial to mesenchymal transition; positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; positive regulation of transcription from RNA polymerase II promoter; regulation of binding; regulation of transforming growth factor beta receptor signaling pathway; response to cholesterol; sequence-specific DNA binding transcription factor activity; signal transduction involved in regulation of gene expression; transcription factor binding; transcription factor complex; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; ureteric bud development; zygotic specification of dorsal/ventral axis" IPR013790; IPR003619; IPR013019; IPR017855; IPR001132; IPR008984; Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (SMAD family member 2) (SMAD 2) (Smad2) Smad2 Madh2 Rattus norvegicus (Rat) TR39134_c1_g2_i3 Q9I9P9 SMAD2_DANRE 2.00E-114 GO:0003677; GO:0005737; GO:0009880; GO:0035556; GO:0046872; GO:0005634; GO:0003700; GO:0005667; GO:0006351; GO:0007179 "DNA binding; cytoplasm; embryonic pattern specification; intracellular signal transduction; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway" IPR013790; IPR003619; IPR013019; IPR017855; IPR001132; IPR008984; Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (SMAD family member 2) (SMAD 2) (Smad2) smad2 madh2 Danio rerio (Zebrafish) (Brachydanio rerio) TR39134_c1_g2_i4 P84025 SMAD3_RAT 2.00E-146 GO:0071141; GO:0007183; GO:0042110; GO:0097296; GO:0007050; GO:0045216; GO:0031490; GO:0000987; GO:0005737; GO:0019049; GO:0097191; GO:0006955; GO:0043066; GO:0030308; GO:0008285; GO:0050728; GO:0045930; GO:0033689; GO:0042177; GO:0001933; GO:0000122; GO:0061045; GO:0038092; GO:0005637; GO:0005634; GO:0001649; GO:0010694; GO:0030501; GO:0090263; GO:0035413; GO:0030335; GO:0032332; GO:0010718; GO:0051894; GO:1901313; GO:0032731; GO:0050927; GO:0051496; GO:0042993; GO:0045944; GO:0032916; GO:0000988; GO:0050821; GO:0043235; GO:0050776; GO:0032909; GO:0001666; GO:0003700; GO:0023019; GO:0008134; GO:0005667; GO:0006351; GO:0060290; GO:0007179; GO:0030618; GO:0006810; GO:0001657; GO:0008270 P47196 "SMAD protein complex; SMAD protein complex assembly; T cell activation; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cell cycle arrest; cell-cell junction organization; chromatin DNA binding; core promoter proximal region sequence-specific DNA binding; cytoplasm; evasion or tolerance of host defenses by virus; extrinsic apoptotic signaling pathway; immune response; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of inflammatory response; negative regulation of mitotic cell cycle; negative regulation of osteoblast proliferation; negative regulation of protein catabolic process; negative regulation of protein phosphorylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of wound healing; nodal signaling pathway; nuclear inner membrane; nucleus; osteoblast differentiation; positive regulation of alkaline phosphatase activity; positive regulation of bone mineralization; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of catenin import into nucleus; positive regulation of cell migration; positive regulation of chondrocyte differentiation; positive regulation of epithelial to mesenchymal transition; positive regulation of focal adhesion assembly; positive regulation of gene expression involved in extracellular matrix organization; positive regulation of interleukin-1 beta production; positive regulation of positive chemotaxis; positive regulation of stress fiber assembly; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor beta3 production; protein binding transcription factor activity; protein stabilization; receptor complex; regulation of immune response; regulation of transforming growth factor beta2 production; response to hypoxia; sequence-specific DNA binding transcription factor activity; signal transduction involved in regulation of gene expression; transcription factor binding; transcription factor complex; transcription, DNA-dependent; transdifferentiation; transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; transport; ureteric bud development; zinc ion binding" IPR013790; IPR003619; IPR013019; IPR017855; IPR001132; IPR008984; Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (SMAD family member 3) (SMAD 3) (Smad3) Smad3 Madh3 Rattus norvegicus (Rat) TR39134_c1_g3_i1 Q3ZBM7 TRPT1_BOVIN 6.00E-08 GO:0000215; GO:0006388 "tRNA 2'-phosphotransferase activity; tRNA splicing, via endonucleolytic cleavage and ligation" IPR002745; tRNA 2'-phosphotransferase 1 (EC 2.7.1.160) TRPT1 Bos taurus (Bovine) TR39134_c1_g3_i2 Q8C7B6 FXL22_MOUSE 1.00E-08 GO:0030018; GO:0016567 Z disc; protein ubiquitination IPR001810; Protein modification; protein ubiquitination. F-box and leucine-rich protein 22 Fbxl22 Mus musculus (Mouse) TR39135_c1_g1_i3 Q5ZMD4 TRI59_CHICK 3.00E-12 GO:0016021; GO:0005622; GO:0008270 integral to membrane; intracellular; zinc ion binding IPR000315; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 59 TRIM59 RCJMB04_2h17 Gallus gallus (Chicken) TR39136_c2_g1_i2 Q01240 NF60_LOLPE 5.00E-70 GO:0005882; GO:0005198 intermediate filament; structural molecule activity IPR001664; IPR016451; IPR018039; 60 kDa neurofilament protein (NF60) Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR39136_c2_g1_i3 P16274 IFEA_HELPO 2.00E-08 GO:0005737; GO:0005882; GO:0005198 cytoplasm; intermediate filament; structural molecule activity IPR001664; IPR018039; Non-neuronal cytoplasmic intermediate filament protein A (IFA) (Fragments) Helix pomatia (Roman snail) (Edible snail) TR39136_c2_g1_i4 Q01241 NF70_LOLPE 4.00E-76 GO:0005882; GO:0005198 intermediate filament; structural molecule activity IPR001664; IPR016451; IPR018039; IPR001322; 70 kDa neurofilament protein (NF70) Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR39136_c2_g1_i5 P09654 VIME_CHICK 2.00E-16 GO:0005882; GO:0005198 intermediate filament; structural molecule activity IPR001664; IPR006821; IPR018039; IPR027699; Vimentin VIM Gallus gallus (Chicken) TR39139_c4_g2_i1 O46037 VINC_DROME 0 GO:0003779; GO:0015629; GO:0007155; GO:0005737; GO:0007016; GO:0005925; GO:0048812; GO:0006909; GO:0005886; GO:0005198 actin binding; actin cytoskeleton; cell adhesion; cytoplasm; cytoskeletal anchoring at plasma membrane; focal adhesion; neuron projection morphogenesis; phagocytosis; plasma membrane; structural molecule activity IPR017997; IPR006077; IPR000633; Vinculin Vinc CG3299 Drosophila melanogaster (Fruit fly) TR39139_c4_g2_i2 O46037 VINC_DROME 0 GO:0003779; GO:0015629; GO:0007155; GO:0005737; GO:0007016; GO:0005925; GO:0048812; GO:0006909; GO:0005886; GO:0005198 actin binding; actin cytoskeleton; cell adhesion; cytoplasm; cytoskeletal anchoring at plasma membrane; focal adhesion; neuron projection morphogenesis; phagocytosis; plasma membrane; structural molecule activity IPR017997; IPR006077; IPR000633; Vinculin Vinc CG3299 Drosophila melanogaster (Fruit fly) TR39139_c4_g2_i4 Q64727 VINC_MOUSE 0 GO:0015629; GO:0034333; GO:0043297; GO:0007155; GO:0043034; GO:0090136; GO:0005916; GO:0005925; GO:0030032; GO:0002009; GO:0005886; GO:0043234; GO:0034394; GO:0030334; GO:0005198 Q61210; P49024; Q8VI36; P26039 actin cytoskeleton; adherens junction assembly; apical junction assembly; cell adhesion; costamere; epithelial cell-cell adhesion; fascia adherens; focal adhesion; lamellipodium assembly; morphogenesis of an epithelium; plasma membrane; protein complex; protein localization to cell surface; regulation of cell migration; structural molecule activity IPR017997; IPR006077; IPR000633; Vinculin (Metavinculin) Vcl Mus musculus (Mouse) TR39139_c4_g2_i5 Q04615 VINC_XENLA 9.00E-60 GO:0015629; GO:0005912; GO:0007155; GO:0005737; GO:0005886; GO:0005198 actin cytoskeleton; adherens junction; cell adhesion; cytoplasm; plasma membrane; structural molecule activity IPR017997; IPR006077; Vinculin (Metavinculin) (Fragment) vcl Xenopus laevis (African clawed frog) TR39139_c4_g2_i6 Q04615 VINC_XENLA 2.00E-19 GO:0015629; GO:0005912; GO:0007155; GO:0005737; GO:0005886; GO:0005198 actin cytoskeleton; adherens junction; cell adhesion; cytoplasm; plasma membrane; structural molecule activity IPR017997; IPR006077; Vinculin (Metavinculin) (Fragment) vcl Xenopus laevis (African clawed frog) TR3914_c0_g1_i1 Q967D7 TUTL_DROME 6.00E-06 GO:0016199; GO:0007414; GO:0070593; GO:0007629; GO:0016021; GO:0030537; GO:0046331; GO:0048814; GO:0008039 Q9VQW7 axon midline choice point recognition; axonal defasciculation; dendrite self-avoidance; flight behavior; integral to membrane; larval behavior; lateral inhibition; regulation of dendrite morphogenesis; synaptic target recognition IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Protein turtle tutl CG15427 Drosophila melanogaster (Fruit fly) TR39140_c0_g1_i1 Q17QM6 EFHD1_BOVIN 1.00E-11 GO:0005509; GO:0005743; GO:0031175 calcium ion binding; mitochondrial inner membrane; neuron projection development IPR011992; IPR002048; EF-hand domain-containing protein D1 (EF-hand domain-containing protein 1) (Swiprosin-2) EFHD1 Bos taurus (Bovine) TR39140_c0_g1_i2 Q9VJ26 EFHD_DROME 7.00E-13 GO:0005509; GO:0007498; GO:0005927; GO:0005886 calcium ion binding; mesoderm development; muscle tendon junction; plasma membrane IPR011992; IPR018247; IPR002048; EF-hand domain-containing protein CG10641 (Swiprosin homolog) CG10641 Drosophila melanogaster (Fruit fly) TR39140_c0_g1_i3 P55007 BART1_RAT 3.00E-26 TR39140_c0_g1_i5 Q3E9C0 CDPKY_ARATH 4.00E-07 GO:0005524; GO:0005509; GO:0005737; GO:0005886; GO:0004672; GO:0004674; GO:0080092 ATP binding; calcium ion binding; cytoplasm; plasma membrane; protein kinase activity; protein serine/threonine kinase activity; regulation of pollen tube growth IPR011992; IPR018247; IPR002048; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium-dependent protein kinase 34 (EC 2.7.11.1) CPK34 At5g19360 F7K24.110 Arabidopsis thaliana (Mouse-ear cress) TR39140_c0_g1_i6 Q9BQI0 AIF1L_HUMAN 2.00E-49 GO:0015629; GO:0051015; GO:0005509; GO:0005737; GO:0005925; GO:0043234; GO:0032587 actin cytoskeleton; actin filament binding; calcium ion binding; cytoplasm; focal adhesion; protein complex; ruffle membrane IPR011992; IPR002048; Allograft inflammatory factor 1-like (Ionized calcium-binding adapter molecule 2) AIF1L C9orf58 IBA2 UNQ672/PRO1306 Homo sapiens (Human) TR39140_c0_g1_i8 P43646 CATR_TETST 1.00E-09 GO:0005524; GO:0008026; GO:0005509; GO:0051301; GO:0007067; GO:0003676 ATP binding; ATP-dependent helicase activity; calcium ion binding; cell division; mitosis; nucleic acid binding IPR011992; IPR018247; IPR002048; IPR000629; Caltractin (Centrin) (Fragment) Tetraselmis striata (Green microalga) TR39141_c1_g4_i1 Q5ZII3 TPRA1_CHICK 6.00E-54 GO:0016021 integral to membrane IPR018781; Transmembrane protein adipocyte-associated 1 homolog (Integral membrane protein GPR175) TPRA1 GPR175 RCJMB04_25o2 Gallus gallus (Chicken) TR39141_c1_g4_i2 Q86W33 TPRA1_HUMAN 4.00E-53 GO:0004930; GO:0007568; GO:0016021; GO:0006629 G-protein coupled receptor activity; aging; integral to membrane; lipid metabolic process IPR018781; Transmembrane protein adipocyte-associated 1 (Integral membrane protein GPR175) (Transmembrane protein 227) TPRA1 GPR175 TMEM227 PP6566 Homo sapiens (Human) TR39142_c1_g1_i1 Q5R7H0 DHTK1_PONAB 0 GO:0006091; GO:0006096; GO:0005739; GO:0004591; GO:0030976; GO:0006099 generation of precursor metabolites and energy; glycolysis; mitochondrion; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding; tricarboxylic acid cycle IPR011603; IPR001017; IPR005475; "Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial (EC 1.2.4.2) (Dehydrogenase E1 and transketolase domain-containing protein 1)" DHTKD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39142_c1_g1_i2 P86231 ODO1_MESAU 9.00E-07 GO:0006096; GO:0005759; GO:0004591; GO:0030976; GO:0006099 glycolysis; mitochondrial matrix; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding; tricarboxylic acid cycle IPR011603; "2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase) (Fragments)" OGDH Mesocricetus auratus (Golden hamster) TR39142_c1_g1_i3 Q5R7H0 DHTK1_PONAB 2.00E-171 GO:0006091; GO:0006096; GO:0005739; GO:0004591; GO:0030976; GO:0006099 generation of precursor metabolites and energy; glycolysis; mitochondrion; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding; tricarboxylic acid cycle IPR011603; IPR001017; IPR005475; "Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial (EC 1.2.4.2) (Dehydrogenase E1 and transketolase domain-containing protein 1)" DHTKD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39144_c0_g1_i1 P13941 CO3A1_RAT 4.00E-41 GO:0007568; GO:0001568; GO:0007160; GO:0071230; GO:0021987; GO:0032964; GO:0030199; GO:0005586; GO:0048565; GO:0043206; GO:0031012; GO:0005201; GO:0005615; GO:0007507; GO:0007229; GO:0046872; GO:0050777; GO:2001223; GO:0018149; GO:0035025; GO:0034097; GO:0009612; GO:0009314; GO:0001501; GO:0043588; GO:0007179; GO:0042060 aging; blood vessel development; cell-matrix adhesion; cellular response to amino acid stimulus; cerebral cortex development; collagen biosynthetic process; collagen fibril organization; collagen type III; digestive tract development; extracellular fibril organization; extracellular matrix; extracellular matrix structural constituent; extracellular space; heart development; integrin-mediated signaling pathway; metal ion binding; negative regulation of immune response; negative regulation of neuron migration; peptide cross-linking; positive regulation of Rho protein signal transduction; response to cytokine stimulus; response to mechanical stimulus; response to radiation; skeletal system development; skin development; transforming growth factor beta receptor signaling pathway; wound healing IPR008160; IPR000885; IPR001007; Collagen alpha-1(III) chain Col3a1 Rattus norvegicus (Rat) TR39144_c0_g1_i3 P13941 CO3A1_RAT 4.00E-41 GO:0007568; GO:0001568; GO:0007160; GO:0071230; GO:0021987; GO:0032964; GO:0030199; GO:0005586; GO:0048565; GO:0043206; GO:0031012; GO:0005201; GO:0005615; GO:0007507; GO:0007229; GO:0046872; GO:0050777; GO:2001223; GO:0018149; GO:0035025; GO:0034097; GO:0009612; GO:0009314; GO:0001501; GO:0043588; GO:0007179; GO:0042060 aging; blood vessel development; cell-matrix adhesion; cellular response to amino acid stimulus; cerebral cortex development; collagen biosynthetic process; collagen fibril organization; collagen type III; digestive tract development; extracellular fibril organization; extracellular matrix; extracellular matrix structural constituent; extracellular space; heart development; integrin-mediated signaling pathway; metal ion binding; negative regulation of immune response; negative regulation of neuron migration; peptide cross-linking; positive regulation of Rho protein signal transduction; response to cytokine stimulus; response to mechanical stimulus; response to radiation; skeletal system development; skin development; transforming growth factor beta receptor signaling pathway; wound healing IPR008160; IPR000885; IPR001007; Collagen alpha-1(III) chain Col3a1 Rattus norvegicus (Rat) TR39146_c1_g1_i1 A3KP85 MET20_DANRE 1.00E-50 GO:0005737; GO:0008276 cytoplasm; protein methyltransferase activity IPR010456; Methyltransferase-like protein 20 (EC 2.1.1.-) mettl20 Danio rerio (Zebrafish) (Brachydanio rerio) TR39149_c1_g2_i1 Q91WM3 U3IP2_MOUSE 1.00E-165 GO:0003723; GO:0005730; GO:0006364; GO:0030529 RNA binding; nucleolus; rRNA processing; ribonucleoprotein complex IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; U3 small nucleolar RNA-interacting protein 2 (RRP9 homolog) (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K) Rrp9 Rnu3ip2 U3-55k Mus musculus (Mouse) TR39149_c2_g1_i1 Q553S2 AP3S_DICDI 5.00E-67 GO:0030123; GO:0006897; GO:0010008; GO:0008565 AP-3 adaptor complex; endocytosis; endosome membrane; protein transporter activity IPR016635; IPR022775; IPR027155; IPR011012; AP-3 complex subunit sigma (AP-3 complex subunit sigma-3) (Adapter-related protein complex 3 subunit sigma) (Sigma-adaptin 3) (Sigma3-adaptin) ap3s1 DDB_G0275405 Dictyostelium discoideum (Slime mold) TR39149_c2_g1_i10 Q09905 AP3S_SCHPO 2.00E-53 GO:0030123; GO:0000139; GO:0006896; GO:0005829; GO:0006886; GO:0005634; GO:0008565 AP-3 adaptor complex; Golgi membrane; Golgi to vacuole transport; cytosol; intracellular protein transport; nucleus; protein transporter activity IPR016635; IPR022775; IPR027155; IPR000804; IPR011012; "AP-3 complex subunit sigma (AP-3 complex sigma3A subunit) (Adapter-related protein complex 3 subunit sigma) (Clathrin-associated/assembly/adapter protein, small 3) (Sigma-adaptin 3A) (Sigma3-adaptin)" aps3 SPAC30D11.05 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR39149_c2_g1_i3 P35604 COPZ1_BOVIN 1.00E-07 GO:0030126; GO:0006891; GO:0006886; GO:0006890 "COPI vesicle coat; intra-Golgi vesicle-mediated transport; intracellular protein transport; retrograde vesicle-mediated transport, Golgi to ER" IPR022775; IPR000804; IPR011012; Coatomer subunit zeta-1 (Zeta-1-coat protein) (Zeta-1 COP) COPZ1 COPZ Bos taurus (Bovine) TR39149_c2_g1_i4 Q1JQA3 AP3S2_BOVIN 2.00E-105 GO:0030123; GO:0005794; GO:0008089; GO:0048490; GO:0030659; GO:0006886; GO:0008565 AP-3 adaptor complex; Golgi apparatus; anterograde axon cargo transport; anterograde synaptic vesicle transport; cytoplasmic vesicle membrane; intracellular protein transport; protein transporter activity IPR016635; IPR022775; IPR000804; IPR011012; AP-3 complex subunit sigma-2 (AP-3 complex subunit sigma-3B) (Adapter-related protein complex 3 subunit sigma-2) (Sigma-3B-adaptin) (Sigma3B-adaptin) (Sigma-adaptin 3b) AP3S2 Bos taurus (Bovine) TR39149_c2_g1_i5 Q9DCR2 AP3S1_MOUSE 1.00E-104 GO:0030123; GO:0005794; GO:0008089; GO:0048490; GO:0030659; GO:0006886; GO:0008565; GO:0005802 AP-3 adaptor complex; Golgi apparatus; anterograde axon cargo transport; anterograde synaptic vesicle transport; cytoplasmic vesicle membrane; intracellular protein transport; protein transporter activity; trans-Golgi network IPR016635; IPR022775; IPR000804; IPR011012; AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adapter-related protein complex 3 subunit sigma-1) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a) Ap3s1 Mus musculus (Mouse) TR39149_c2_g1_i8 Q9DCR2 AP3S1_MOUSE 3.00E-107 GO:0030123; GO:0005794; GO:0008089; GO:0048490; GO:0030659; GO:0006886; GO:0008565; GO:0005802 AP-3 adaptor complex; Golgi apparatus; anterograde axon cargo transport; anterograde synaptic vesicle transport; cytoplasmic vesicle membrane; intracellular protein transport; protein transporter activity; trans-Golgi network IPR016635; IPR022775; IPR000804; IPR011012; AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adapter-related protein complex 3 subunit sigma-1) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a) Ap3s1 Mus musculus (Mouse) TR39149_c2_g1_i9 P61967 AP1S1_MOUSE 3.00E-27 GO:0030121; GO:0005905; GO:0006897; GO:0006886; GO:0008565; GO:0009615; GO:0005802; GO:0016192 AP-1 adaptor complex; coated pit; endocytosis; intracellular protein transport; protein transporter activity; response to virus; trans-Golgi network; vesicle-mediated transport IPR016635; IPR022775; IPR000804; IPR011012; AP-1 complex subunit sigma-1A (Adapter-related protein complex 1 subunit sigma-1A) (Adaptor protein complex AP-1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin) Ap1s1 Ap19 Mus musculus (Mouse) TR3915_c1_g1_i1 Q9WVF7 DPOE1_MOUSE 1.00E-57 GO:0051539; GO:0003677; GO:0006260; GO:0000731; GO:0003887; GO:0000082; GO:0006287; GO:0003682; GO:0008622; GO:0000166; GO:0006297; GO:0008270 "4 iron, 4 sulfur cluster binding; DNA binding; DNA replication; DNA synthesis involved in DNA repair; DNA-directed DNA polymerase activity; G1/S transition of mitotic cell cycle; base-excision repair, gap-filling; chromatin binding; epsilon DNA polymerase complex; nucleotide binding; nucleotide-excision repair, DNA gap filling; zinc ion binding" IPR006172; IPR006133; IPR006134; IPR013697; IPR012337; DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A) Pole Pole1 Mus musculus (Mouse) TR39151_c2_g1_i1 Q2QI47 USH2A_MOUSE 2.00E-09 GO:0016324; GO:0005604; GO:0005518; GO:0005737; GO:0035315; GO:0060113; GO:0016021; GO:0048496; GO:0045494; GO:0050896; GO:0007605; GO:0002142; GO:0060171; GO:0007601 apical plasma membrane; basement membrane; collagen binding; cytoplasm; hair cell differentiation; inner ear receptor cell differentiation; integral to membrane; maintenance of organ identity; photoreceptor cell maintenance; response to stimulus; sensory perception of sound; stereocilia ankle link complex; stereocilium membrane; visual perception IPR008985; IPR013320; IPR002049; IPR003961; IPR013783; IPR001791; IPR008211; IPR026915; Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog) Ush2A Gm676 Mus musculus (Mouse) TR39151_c3_g1_i1 P00529 ROS_AVISU 2.00E-131 GO:0005524; GO:0016020; GO:0018108; GO:0004714; GO:0007169 ATP binding; membrane; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR002011; Tyrosine-protein kinase transforming protein ros (EC 2.7.10.1) V-ROS UR2 sarcoma virus (UR2SV) (Avian sarcoma virus (strain UR2)) TR39154_c1_g1_i1 O28579 SYW_ARCFU 2.00E-21 GO:0005524; GO:0005737; GO:0004830; GO:0006436 ATP binding; cytoplasm; tryptophan-tRNA ligase activity; tryptophanyl-tRNA aminoacylation IPR002305; IPR014729; IPR002306; IPR020653; Tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) trpS AF_1694 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) TR39154_c1_g1_i2 P23381 SYWC_HUMAN 0 GO:0005524; GO:0001525; GO:0005829; GO:0008285; GO:0045765; GO:0004830; GO:0006436 ATP binding; angiogenesis; cytosol; negative regulation of cell proliferation; regulation of angiogenesis; tryptophan-tRNA ligase activity; tryptophanyl-tRNA aminoacylation IPR001412; IPR002305; IPR014729; IPR009068; IPR002306; IPR000738; "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" WARS IFI53 WRS Homo sapiens (Human) TR39154_c1_g1_i3 P17248 SYWC_BOVIN 0 GO:0005524; GO:0005737; GO:0045765; GO:0004830; GO:0006436 ATP binding; cytoplasm; regulation of angiogenesis; tryptophan-tRNA ligase activity; tryptophanyl-tRNA aminoacylation IPR001412; IPR002305; IPR014729; IPR009068; IPR002306; IPR000738; "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" WARS Bos taurus (Bovine) TR39155_c4_g3_i1 P08169 MPRI_BOVIN 6.00E-46 GO:0009986; GO:0030139; GO:0001948; GO:0016021; GO:0005765; GO:0051219; GO:0005215 cell surface; endocytic vesicle; glycoprotein binding; integral to membrane; lysosomal membrane; phosphoprotein binding; transporter activity IPR000479; IPR000562; IPR013806; IPR009011; Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (CD antigen CD222) IGF2R M6P Bos taurus (Bovine) TR39156_c0_g1_i1 Q9CPY4 CDKA2_MOUSE 1.00E-20 IPR017266; IPR019187; Cyclin-dependent kinase 2-associated protein 2 (CDK2-associated protein 2) (DOC-1-related protein) (DOC-1R) Cdk2ap2 D19Ertd144e Doc1r Mus musculus (Mouse) TR39156_c0_g1_i4 Q9CPY4 CDKA2_MOUSE 1.00E-21 IPR017266; IPR019187; Cyclin-dependent kinase 2-associated protein 2 (CDK2-associated protein 2) (DOC-1-related protein) (DOC-1R) Cdk2ap2 D19Ertd144e Doc1r Mus musculus (Mouse) TR39156_c0_g2_i1 Q9CYU6 WDR85_MOUSE 5.00E-88 GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; peptidyl-diphthamide biosynthesis. Diphthamide biosynthesis protein 7 (DPH7) (WD repeat-containing protein 85) Dph7 Wdr85 Mus musculus (Mouse) TR39156_c0_g2_i2 Q55C80 WDR85_DICDI 1.00E-59 GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine IPR015943; IPR001680; IPR017986; Protein modification; peptidyl-diphthamide biosynthesis. Diphthamide biosynthesis protein 7 homolog (WD repeat-containing protein 85 homolog) wdr85 DDB_G0270178 Dictyostelium discoideum (Slime mold) TR39158_c1_g1_i1 Q3SYW0 FBX15_BOVIN 4.00E-28 IPR001810; F-box only protein 15 FBXO15 Bos taurus (Bovine) TR39158_c3_g1_i1 Q9Z2A7 DGAT1_MOUSE 6.00E-156 GO:0003846; GO:0004144; GO:0046339; GO:0005789; GO:0055089; GO:0016021; GO:0043231; GO:0019915; GO:0035336; GO:0050252; GO:0042572; GO:0019432; GO:0034379 2-acylglycerol O-acyltransferase activity; diacylglycerol O-acyltransferase activity; diacylglycerol metabolic process; endoplasmic reticulum membrane; fatty acid homeostasis; integral to membrane; intracellular membrane-bounded organelle; lipid storage; long-chain fatty-acyl-CoA metabolic process; retinol O-fatty-acyltransferase activity; retinol metabolic process; triglyceride biosynthetic process; very-low-density lipoprotein particle assembly IPR027251; IPR004299; IPR014371; Lipid metabolism; glycerolipid metabolism. Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase) Dgat1 Dgat Mus musculus (Mouse) TR39158_c3_g1_i3 Q55BH9 DGAT1_DICDI 2.00E-75 GO:0003846; GO:0004144; GO:0005789; GO:0006071; GO:0016021; GO:0019432 2-acylglycerol O-acyltransferase activity; diacylglycerol O-acyltransferase activity; endoplasmic reticulum membrane; glycerol metabolic process; integral to membrane; triglyceride biosynthetic process IPR004299; IPR014371; Lipid metabolism; glycerolipid metabolism. Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) dgat1 DDB_G0271342 Dictyostelium discoideum (Slime mold) TR39159_c3_g1_i1 Q9UJU3 ZF112_HUMAN 2.00E-66 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 112 (Zfp-112) (Zinc finger protein 228) ZNF112 ZFP112 ZNF228 Homo sapiens (Human) TR39159_c3_g1_i2 Q8N4W9 ZN808_HUMAN 4.00E-55 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 808 ZNF808 Homo sapiens (Human) TR39159_c4_g1_i1 Q8BWT5 DIP2A_MOUSE 3.00E-09 GO:0003824; GO:0007275; GO:0005634 catalytic activity; multicellular organismal development; nucleus IPR000873; IPR010506; Disco-interacting protein 2 homolog A (DIP2 homolog A) Dip2a Dip2 Kiaa0184 Mus musculus (Mouse) TR39160_c0_g1_i1 Q01484 ANK2_HUMAN 3.00E-81 GO:0051117; GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0007411; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005829; GO:0005887; GO:0014704; GO:0044325; GO:0086046; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307; GO:0070296 P11532-5; P62993 "ATPase binding; M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; axon guidance; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; cytosol; integral to plasma membrane; intercalated disc; ion channel binding; membrane depolarization involved in regulation of SA node cell action potential; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization; sarcoplasmic reticulum calcium ion transport" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) TR39160_c0_g1_i2 O15084 ANR28_HUMAN 0 GO:0005654 Q14185; O00743; Q9UPN7; O75170; Q5H9R7; Q9H2K2 nucleoplasm IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) ANKRD28 KIAA0379 Homo sapiens (Human) TR39160_c0_g1_i3 Q6RI86 TRPA1_RAT 6.00E-45 GO:0016021; GO:0006811; GO:0050896 integral to membrane; ion transport; response to stimulus IPR002110; IPR020683; Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) Trpa1 Anktm1 Rattus norvegicus (Rat) TR39160_c0_g1_i4 O15084 ANR28_HUMAN 0 GO:0005654 Q14185; O00743; Q9UPN7; O75170; Q5H9R7; Q9H2K2 nucleoplasm IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) ANKRD28 KIAA0379 Homo sapiens (Human) TR39161_c0_g2_i1 A2AIW0 SDCG3_MOUSE 3.00E-22 GO:0005737 cytoplasm IPR026757; Serologically defined colon cancer antigen 3 homolog Sdccag3 Mus musculus (Mouse) TR39162_c3_g2_i1 Q99MZ7 PECR_MOUSE 3.00E-87 GO:0030497; GO:0005739; GO:0005778; GO:0033306; GO:0019166 fatty acid elongation; mitochondrion; peroxisomal membrane; phytol metabolic process; trans-2-enoyl-CoA reductase (NADPH) activity IPR002347; IPR016040; Lipid metabolism; fatty acid biosynthesis. Peroxisomal trans-2-enoyl-CoA reductase (TERP) (EC 1.3.1.38) Pecr Mus musculus (Mouse) TR39162_c3_g2_i3 Q9JIF5 PECR_CAVPO 1.00E-83 GO:0006633; GO:0005739; GO:0005778; GO:0033306; GO:0019166 fatty acid biosynthetic process; mitochondrion; peroxisomal membrane; phytol metabolic process; trans-2-enoyl-CoA reductase (NADPH) activity IPR002347; IPR016040; Lipid metabolism; fatty acid biosynthesis. Peroxisomal trans-2-enoyl-CoA reductase (EC 1.3.1.38) PECR Cavia porcellus (Guinea pig) TR39162_c3_g3_i1 Q8JIS3 DER_CHICK 1.00E-12 GO:0042732; GO:0050038; GO:0005737; GO:0047880 D-xylose metabolic process; L-xylulose reductase (NADP+) activity; cytoplasm; erythrulose reductase activity IPR002198; IPR002347; IPR016040; IPR020904; D-erythrulose reductase (EC 1.1.1.162) (Probable L-xylulose reductase) (XR) (EC 1.1.1.10) DER Gallus gallus (Chicken) TR39163_c0_g2_i1 P15505 GCSP_CHICK 0 GO:0006546; GO:0004375; GO:0016829; GO:0005739; GO:0030170 glycine catabolic process; glycine dehydrogenase (decarboxylating) activity; lyase activity; mitochondrion; pyridoxal phosphate binding IPR001597; IPR020580; IPR020581; IPR003437; IPR015424; IPR015421; "Glycine dehydrogenase [decarboxylating], mitochondrial (EC 1.4.4.2) (Glycine cleavage system P protein) (Glycine decarboxylase)" GLDC Gallus gallus (Chicken) TR39163_c0_g3_i1 Q91W43 GCSP_MOUSE 0 GO:0006546; GO:0004375; GO:0016829; GO:0005739; GO:0030170 glycine catabolic process; glycine dehydrogenase (decarboxylating) activity; lyase activity; mitochondrion; pyridoxal phosphate binding IPR001597; IPR020580; IPR020581; IPR003437; IPR015424; IPR015421; "Glycine dehydrogenase [decarboxylating], mitochondrial (EC 1.4.4.2) (Glycine cleavage system P protein) (Glycine decarboxylase)" Gldc Mus musculus (Mouse) TR39163_c0_g4_i1 Q8CXE1 GCSPB_OCEIH 2.00E-22 GO:0019464; GO:0004375; GO:0030170 glycine decarboxylation via glycine cleavage system; glycine dehydrogenase (decarboxylating) activity; pyridoxal phosphate binding IPR020580; IPR020581; IPR023012; IPR015424; IPR015421; Probable glycine dehydrogenase [decarboxylating] subunit 2 (EC 1.4.4.2) (Glycine cleavage system P-protein subunit 2) (Glycine decarboxylase subunit 2) gcvPB OB1902 Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831) TR39163_c0_g4_i2 A4SCK8 GCSPB_PROVI 5.00E-31 GO:0019464; GO:0004375; GO:0030170 glycine decarboxylation via glycine cleavage system; glycine dehydrogenase (decarboxylating) activity; pyridoxal phosphate binding IPR020580; IPR020581; IPR023012; IPR015424; IPR015421; Probable glycine dehydrogenase [decarboxylating] subunit 2 (EC 1.4.4.2) (Glycine cleavage system P-protein subunit 2) (Glycine decarboxylase subunit 2) gcvPB Cvib_0194 Prosthecochloris vibrioformis (strain DSM 265) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 265)) (Chlorobium phaeovibrioides (strain DSM 265)) TR39164_c1_g1_i1 Q86B06 SDHL_DICDI 4.00E-57 GO:0003941; GO:0006520; GO:0005737; GO:0006094; GO:0030170 L-serine ammonia-lyase activity; cellular amino acid metabolic process; cytoplasm; gluconeogenesis; pyridoxal phosphate binding IPR000634; IPR001926; Carbohydrate biosynthesis; gluconeogenesis. L-serine dehydratase (SDH) (EC 4.3.1.17) (L-serine deaminase) sds DDB_G0272787 Dictyostelium discoideum (Slime mold) TR39164_c1_g1_i3 Q8R238 SDSL_MOUSE 2.00E-81 GO:0003941; GO:0004794; GO:0005739 L-serine ammonia-lyase activity; L-threonine ammonia-lyase activity; mitochondrion IPR001926; Serine dehydratase-like (EC 4.3.1.17) (L-serine deaminase) (L-serine dehydratase/L-threonine deaminase) (L-threonine dehydratase) (TDH) (EC 4.3.1.19) (SDH) Sdsl Sds Mus musculus (Mouse) TR39164_c1_g1_i4 P25379 STDH_YEAST 6.00E-21 GO:0003941; GO:0006565; GO:0004794; GO:0042645; GO:0030170; GO:0006567 L-serine ammonia-lyase activity; L-serine catabolic process; L-threonine ammonia-lyase activity; mitochondrial nucleoid; pyridoxal phosphate binding; threonine catabolic process IPR000634; IPR001926; Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase (EC 4.3.1.17) (L-serine deaminase); L-threonine dehydratase (EC 4.3.1.19) (L-threonine deaminase)] CHA1 YCL064C YCL64C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39164_c1_g1_i5 Q9ZSS6 THD1_ARATH 5.00E-13 GO:0004794; GO:0009507; GO:0009097; GO:0030170 L-threonine ammonia-lyase activity; chloroplast; isoleucine biosynthetic process; pyridoxal phosphate binding IPR000634; IPR005787; IPR001721; IPR001926; Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1. "Threonine dehydratase biosynthetic, chloroplastic (EC 4.3.1.19) (Threonine deaminase) (TD)" OMR1 At3g10050 T22K18.12 Arabidopsis thaliana (Mouse-ear cress) TR39164_c1_g1_i6 Q8R238 SDSL_MOUSE 3.00E-73 GO:0003941; GO:0004794; GO:0005739 L-serine ammonia-lyase activity; L-threonine ammonia-lyase activity; mitochondrion IPR001926; Serine dehydratase-like (EC 4.3.1.17) (L-serine deaminase) (L-serine dehydratase/L-threonine deaminase) (L-threonine dehydratase) (TDH) (EC 4.3.1.19) (SDH) Sdsl Sds Mus musculus (Mouse) TR39166_c0_g1_i1 Q8AVM5 VPP1_XENLA 0 GO:0015991; GO:0030659; GO:0015078; GO:0016021; GO:0042470; GO:0000220 "ATP hydrolysis coupled proton transport; cytoplasmic vesicle membrane; hydrogen ion transmembrane transporter activity; integral to membrane; melanosome; vacuolar proton-transporting V-type ATPase, V0 domain" IPR002490; IPR026028; V-type proton ATPase 116 kDa subunit a isoform 1 (V-ATPase 116 kDa isoform a1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1) atp6v0a1 Xenopus laevis (African clawed frog) TR39166_c0_g1_i2 Q9Z1G4 VPP1_MOUSE 0 GO:0015991; GO:0005737; GO:0030659; GO:0015078; GO:0016021; GO:0042470; GO:0000220 P49769 "ATP hydrolysis coupled proton transport; cytoplasm; cytoplasmic vesicle membrane; hydrogen ion transmembrane transporter activity; integral to membrane; melanosome; vacuolar proton-transporting V-type ATPase, V0 domain" IPR002490; IPR026028; V-type proton ATPase 116 kDa subunit a isoform 1 (V-ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1) Atp6v0a1 Atp6n1 Mus musculus (Mouse) TR39166_c1_g1_i1 Q9HBG4 VPP4_HUMAN 0 GO:0015991; GO:0016324; GO:0031526; GO:0006879; GO:0010008; GO:0007588; GO:0015078; GO:0008286; GO:0016021; GO:0051701; GO:0005765; GO:0001503; GO:0030670; GO:0090382; GO:0015992; GO:0006885; GO:0007605; GO:0033572; GO:0055085; GO:0000220 "ATP hydrolysis coupled proton transport; apical plasma membrane; brush border membrane; cellular iron ion homeostasis; endosome membrane; excretion; hydrogen ion transmembrane transporter activity; insulin receptor signaling pathway; integral to membrane; interaction with host; lysosomal membrane; ossification; phagocytic vesicle membrane; phagosome maturation; proton transport; regulation of pH; sensory perception of sound; transferrin transport; transmembrane transport; vacuolar proton-transporting V-type ATPase, V0 domain" IPR002490; IPR026028; V-type proton ATPase 116 kDa subunit a isoform 4 (V-ATPase 116 kDa isoform a4) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4) (Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform) ATP6V0A4 ATP6N1B ATP6N2 Homo sapiens (Human) TR39166_c1_g1_i3 P37296 STV1_YEAST 3.00E-121 GO:0015991; GO:0005794; GO:0000139; GO:0010008; GO:0016021; GO:0005770; GO:0046961; GO:0007035; GO:0000220 "ATP hydrolysis coupled proton transport; Golgi apparatus; Golgi membrane; endosome membrane; integral to membrane; late endosome; proton-transporting ATPase activity, rotational mechanism; vacuolar acidification; vacuolar proton-transporting V-type ATPase, V0 domain" IPR002490; IPR026028; "V-type proton ATPase subunit a, Golgi isoform (V-ATPase a 2 subunit) (Similar to VPH1 protein 1) (V-ATPase 101 kDa subunit) (V-ATPase subunit AC115) (Vacuolar proton translocating ATPase subunit a 2)" STV1 YMR054W YM9796.07 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39167_c0_g1_i2 O15540 FABP7_HUMAN 1.00E-18 GO:0042995; GO:0021846; GO:0005737; GO:0050673; GO:0008289; GO:0008285; GO:0007399; GO:0022008; GO:0043025; GO:0005634; GO:0060134; GO:0005215 cell projection; cell proliferation in forebrain; cytoplasm; epithelial cell proliferation; lipid binding; negative regulation of cell proliferation; nervous system development; neurogenesis; neuronal cell body; nucleus; prepulse inhibition; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; "Fatty acid-binding protein, brain (Brain lipid-binding protein) (BLBP) (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7) (Mammary-derived growth inhibitor related)" FABP7 BLBP FABPB MRG Homo sapiens (Human) TR39167_c0_g1_i3 O15540 FABP7_HUMAN 1.00E-18 GO:0042995; GO:0021846; GO:0005737; GO:0050673; GO:0008289; GO:0008285; GO:0007399; GO:0022008; GO:0043025; GO:0005634; GO:0060134; GO:0005215 cell projection; cell proliferation in forebrain; cytoplasm; epithelial cell proliferation; lipid binding; negative regulation of cell proliferation; nervous system development; neurogenesis; neuronal cell body; nucleus; prepulse inhibition; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; "Fatty acid-binding protein, brain (Brain lipid-binding protein) (BLBP) (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7) (Mammary-derived growth inhibitor related)" FABP7 BLBP FABPB MRG Homo sapiens (Human) TR39168_c1_g3_i1 P04041 GPX1_RAT 8.00E-76 GO:0007568; GO:0005829; GO:0043295; GO:0006749; GO:0004602; GO:0042744; GO:0005634; GO:0047066; GO:0032355; GO:0051593; GO:0009749; GO:0006982; GO:0035094; GO:0010269; GO:0008430 aging; cytosol; glutathione binding; glutathione metabolic process; glutathione peroxidase activity; hydrogen peroxide catabolic process; nucleus; phospholipid-hydroperoxide glutathione peroxidase activity; response to estradiol stimulus; response to folic acid; response to glucose stimulus; response to lipid hydroperoxide; response to nicotine; response to selenium ion; selenium binding IPR000889; IPR012336; Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase) Gpx1 Rattus norvegicus (Rat) TR39168_c1_g3_i2 P30710 GPX5_RAT 1.00E-37 GO:0005576; GO:0004602; GO:0006979 extracellular region; glutathione peroxidase activity; response to oxidative stress IPR000889; IPR012336; Epididymal secretory glutathione peroxidase (EC 1.11.1.9) (Epididymis-specific glutathione peroxidase-like protein) (EGLP) (Glutathione peroxidase 5) (GPx-5) (GSHPx-5) Gpx5 Rattus norvegicus (Rat) TR39168_c1_g3_i3 Q4AEI3 GPX1_PONPY 9.00E-73 GO:0005737; GO:0004602; GO:0006979 cytoplasm; glutathione peroxidase activity; response to oxidative stress IPR000889; IPR012336; Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase) GPX1 Pongo pygmaeus (Bornean orangutan) TR39168_c1_g3_i4 Q8MJ14 GPX1_PIG 3.00E-72 GO:0005737; GO:0004602; GO:0006979 cytoplasm; glutathione peroxidase activity; response to oxidative stress IPR000889; IPR012336; Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase) GPX1 Sus scrofa (Pig) TR39168_c1_g3_i5 P11352 GPX1_MOUSE 1.00E-30 GO:0060055; GO:0043534; GO:0001885; GO:0045444; GO:0004602; GO:0060047; GO:0042744; GO:0051702; GO:0008631; GO:0005739; GO:0051450; GO:0014902; GO:0043066; GO:0002862; GO:1902176; GO:0051897; GO:0018158; GO:0043523; GO:0010332; GO:0033194; GO:0009609; GO:0009636; GO:0009410; GO:0007605; GO:0048741; GO:0043403; GO:0001659; GO:0006641; GO:0042311 angiogenesis involved in wound healing; blood vessel endothelial cell migration; endothelial cell development; fat cell differentiation; glutathione peroxidase activity; heart contraction; hydrogen peroxide catabolic process; interaction with symbiont; intrinsic apoptotic signaling pathway in response to oxidative stress; mitochondrion; myoblast proliferation; myotube differentiation; negative regulation of apoptotic process; negative regulation of inflammatory response to antigenic stimulus; negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of protein kinase B signaling cascade; protein oxidation; regulation of neuron apoptotic process; response to gamma radiation; response to hydroperoxide; response to symbiotic bacterium; response to toxic substance; response to xenobiotic stimulus; sensory perception of sound; skeletal muscle fiber development; skeletal muscle tissue regeneration; temperature homeostasis; triglyceride metabolic process; vasodilation IPR000889; IPR012336; Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase) (Selenium-dependent glutathione peroxidase 1) Gpx1 Mus musculus (Mouse) TR39169_c4_g1_i1 O43159 RRP8_HUMAN 7.00E-76 GO:0008757; GO:0042149; GO:0016568; GO:0000183; GO:0005677; GO:0005737; GO:0072332; GO:0035064; GO:0005730; GO:0005886; GO:0071158; GO:0033553; GO:0006364; GO:0046015; GO:0006351 Q96EB6; O43463 "S-adenosylmethionine-dependent methyltransferase activity; cellular response to glucose starvation; chromatin modification; chromatin silencing at rDNA; chromatin silencing complex; cytoplasm; intrinsic apoptotic signaling pathway by p53 class mediator; methylated histone residue binding; nucleolus; plasma membrane; positive regulation of cell cycle arrest; rDNA heterochromatin; rRNA processing; regulation of transcription by glucose; transcription, DNA-dependent" IPR007823; IPR023576; Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin) RRP8 KIAA0409 NML hucep-1 Homo sapiens (Human) TR39169_c4_g1_i2 Q7K2B0 RRP8_DROME 4.00E-62 GO:0016568; GO:0000183; GO:0005677; GO:0035064; GO:0008168; GO:0005730; GO:0033553; GO:0006364; GO:0006351 "chromatin modification; chromatin silencing at rDNA; chromatin silencing complex; methylated histone residue binding; methyltransferase activity; nucleolus; rDNA heterochromatin; rRNA processing; transcription, DNA-dependent" IPR007823; Ribosomal RNA-processing protein 8 (EC 2.1.1.-) CG7137 Drosophila melanogaster (Fruit fly) TR39170_c1_g2_i2 P58557 YBEY_HUMAN 8.00E-35 GO:0046872; GO:0004222; GO:0005739; GO:0005634; GO:0006364 metal ion binding; metalloendopeptidase activity; mitochondrion; nucleus; rRNA processing IPR023091; IPR002036; IPR020549; Putative ribonuclease YBEY C21orf57 Homo sapiens (Human) TR39170_c1_g2_i3 P58557 YBEY_HUMAN 8.00E-37 GO:0046872; GO:0004222; GO:0005739; GO:0005634; GO:0006364 metal ion binding; metalloendopeptidase activity; mitochondrion; nucleus; rRNA processing IPR023091; IPR002036; IPR020549; Putative ribonuclease YBEY C21orf57 Homo sapiens (Human) TR39172_c0_g1_i2 Q7ZTY6 CG026_DANRE 6.00E-34 IPR027844; Uncharacterized protein C7orf26 homolog zgc:56409 Danio rerio (Zebrafish) (Brachydanio rerio) TR39173_c1_g1_i1 Q96EZ8 MCRS1_HUMAN 7.00E-45 GO:0006310; GO:0006281; GO:0031011; GO:0071339; GO:0005737; GO:0043984; GO:0043981; GO:0043982; GO:0000123; GO:0006355; GO:0006351 Q9Y3C0; Q9UER7; Q99683; Q8IXK0 "DNA recombination; DNA repair; Ino80 complex; MLL1 complex; cytoplasm; histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase complex; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000253; IPR025999; IPR008984; Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) MCRS1 INO80Q MSP58 Homo sapiens (Human) TR39173_c1_g1_i2 Q96EZ8 MCRS1_HUMAN 0 GO:0006310; GO:0006281; GO:0031011; GO:0071339; GO:0005737; GO:0043984; GO:0043981; GO:0043982; GO:0000123; GO:0006355; GO:0006351 Q9Y3C0; Q9UER7; Q99683; Q8IXK0 "DNA recombination; DNA repair; Ino80 complex; MLL1 complex; cytoplasm; histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase complex; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000253; IPR025999; IPR008984; Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) MCRS1 INO80Q MSP58 Homo sapiens (Human) TR39175_c0_g4_i3 P27701 CD82_HUMAN 2.00E-07 GO:0005887 Q8TAA9 integral to plasma membrane IPR000301; IPR018499; IPR018503; IPR008952; CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82) CD82 KAI1 SAR2 ST6 TSPAN27 Homo sapiens (Human) TR39176_c0_g1_i1 Q61102 ABCB7_MOUSE 0 GO:0005524; GO:0042626; GO:0006879; GO:0016021; GO:0005743 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; cellular iron ion homeostasis; integral to membrane; mitochondrial inner membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; "ATP-binding cassette sub-family B member 7, mitochondrial (ATP-binding cassette transporter 7) (ABC transporter 7 protein)" Abcb7 Abc7 Mus musculus (Mouse) TR39176_c0_g1_i2 Q5ZUH9 MSBA_LEGPH 6.00E-70 GO:0005524; GO:0006200; GO:0016021; GO:0034040; GO:0005886 ATP binding; ATP catabolic process; integral to membrane; lipid-transporting ATPase activity; plasma membrane IPR003593; IPR011527; IPR003439; IPR017871; IPR011917; IPR001140; IPR027417; Lipid A export ATP-binding/permease protein MsbA (EC 3.6.3.-) msbA lpg1819 Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) TR39176_c0_g1_i3 Q61102 ABCB7_MOUSE 3.00E-50 GO:0005524; GO:0042626; GO:0006879; GO:0016021; GO:0005743 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; cellular iron ion homeostasis; integral to membrane; mitochondrial inner membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; "ATP-binding cassette sub-family B member 7, mitochondrial (ATP-binding cassette transporter 7) (ABC transporter 7 protein)" Abcb7 Abc7 Mus musculus (Mouse) TR39176_c0_g3_i1 Q54LE6 ABCC5_DICDI 1.00E-14 GO:0005524; GO:0042626; GO:0016021 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; integral to membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; ABC transporter C family member 5 (ABC transporter ABCC.5) abcC5 DDB_G0286559 Dictyostelium discoideum (Slime mold) TR39177_c2_g1_i2 Q6L6Q6 LYS_CRAGI 2.00E-33 GO:0019835; GO:0042742; GO:0005576; GO:0003796 cytolysis; defense response to bacterium; extracellular region; lysozyme activity IPR008597; IPR023346; "Lysozyme (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase)" lysoz Crassostrea gigas (Pacific oyster) (Crassostrea angulata) TR39179_c0_g1_i1 Q0VA82 MFSD8_DANRE 2.00E-08 GO:0016021; GO:0005765; GO:0055085 integral to membrane; lysosomal membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Major facilitator superfamily domain-containing protein 8 mfsd8 zgc:136865 Danio rerio (Zebrafish) (Brachydanio rerio) TR39179_c0_g1_i2 Q8BH31 MFSD8_MOUSE 1.00E-15 GO:0016021; GO:0005765; GO:0005764; GO:0005634; GO:0055085 integral to membrane; lysosomal membrane; lysosome; nucleus; transmembrane transport IPR011701; IPR020846; IPR016196; Major facilitator superfamily domain-containing protein 8 Mfsd8 Mus musculus (Mouse) TR39179_c0_g1_i3 Q6GPQ3 MFSD8_XENLA 8.00E-17 GO:0016021; GO:0005765; GO:0055085 integral to membrane; lysosomal membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Major facilitator superfamily domain-containing protein 8 mfsd8 Xenopus laevis (African clawed frog) TR39181_c1_g1_i1 Q14517 FAT1_HUMAN 4.00E-29 GO:0007015; GO:0009653; GO:0005509; GO:0016477; GO:0016337; GO:0005911; GO:0007267; GO:0007163; GO:0030175; GO:0007156; GO:0005887; GO:0030027; GO:0005634; GO:0048471 Q8N8S7; Q9NSC5; Q99JP6 actin filament organization; anatomical structure morphogenesis; calcium ion binding; cell migration; cell-cell adhesion; cell-cell junction; cell-cell signaling; establishment or maintenance of cell polarity; filopodium; homophilic cell adhesion; integral to plasma membrane; lamellipodium; nucleus; perinuclear region of cytoplasm IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) TR39181_c1_g1_i2 Q61982 NOTC3_MOUSE 1.00E-27 GO:0007219; GO:0005509; GO:0030900; GO:0072104; GO:0005887; GO:0045665; GO:0048663; GO:0005634; GO:0048661; GO:0006355; GO:0006351 "Notch signaling pathway; calcium ion binding; forebrain development; glomerular capillary formation; integral to plasma membrane; negative regulation of neuron differentiation; neuron fate commitment; nucleus; positive regulation of smooth muscle cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022331; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] Notch3 Mus musculus (Mouse) TR39181_c1_g1_i3 Q14517 FAT1_HUMAN 7.00E-29 GO:0007015; GO:0009653; GO:0005509; GO:0016477; GO:0016337; GO:0005911; GO:0007267; GO:0007163; GO:0030175; GO:0007156; GO:0005887; GO:0030027; GO:0005634; GO:0048471 Q8N8S7; Q9NSC5; Q99JP6 actin filament organization; anatomical structure morphogenesis; calcium ion binding; cell migration; cell-cell adhesion; cell-cell junction; cell-cell signaling; establishment or maintenance of cell polarity; filopodium; homophilic cell adhesion; integral to plasma membrane; lamellipodium; nucleus; perinuclear region of cytoplasm IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) TR39181_c1_g1_i4 O14594 NCAN_HUMAN 2.00E-27 GO:0005796; GO:0007411; GO:0005509; GO:0030246; GO:0005975; GO:0007155; GO:0030206; GO:0030207; GO:0030208; GO:0030198; GO:0005576; GO:0005540; GO:0043202; GO:0051823 Golgi lumen; axon guidance; calcium ion binding; carbohydrate binding; carbohydrate metabolic process; cell adhesion; chondroitin sulfate biosynthetic process; chondroitin sulfate catabolic process; dermatan sulfate biosynthetic process; extracellular matrix organization; extracellular region; hyaluronic acid binding; lysosomal lumen; regulation of synapse structural plasticity IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Neurocan core protein (Chondroitin sulfate proteoglycan 3) NCAN CSPG3 NEUR Homo sapiens (Human) TR39181_c1_g1_i5 O43854 EDIL3_HUMAN 7.00E-13 GO:0005509; GO:0007155; GO:0070062; GO:0005178; GO:0007275; GO:0010811 calcium ion binding; cell adhesion; extracellular vesicular exosome; integrin binding; multicellular organismal development; positive regulation of cell-substrate adhesion IPR000421; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR008979; EGF-like repeat and discoidin I-like domain-containing protein 3 (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1) EDIL3 DEL1 Homo sapiens (Human) TR39181_c1_g1_i6 Q70E20 SNED1_MOUSE 1.00E-26 GO:0005509; GO:0007160; GO:0005576 calcium ion binding; cell-matrix adhesion; extracellular region IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003961; IPR009030; IPR013783; IPR003886; IPR000436; "Sushi, nidogen and EGF-like domain-containing protein 1 (Secreted protein SST-3) (Stromal nidogen extracellular matrix protein)" Sned1 Snep Mus musculus (Mouse) TR39183_c1_g1_i1 Q9Y573 IPP_HUMAN 1.00E-58 GO:0003779; GO:0015629; GO:0005737 actin binding; actin cytoskeleton; cytoplasm IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR017096; IPR015915; IPR006652; Actin-binding protein IPP (Intracisternal A particle-promoted polypeptide) (IPP) (Kelch-like protein 27) IPP KLHL27 Homo sapiens (Human) TR39183_c1_g1_i2 Q920Q8 NS1BP_MOUSE 4.00E-35 GO:0005737; GO:0005856; GO:2001243; GO:0005634 cytoplasm; cytoskeleton; negative regulation of intrinsic apoptotic signaling pathway; nucleus IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR015915; IPR006652; Influenza virus NS1A-binding protein homolog (NS1-BP) (NS1-binding protein homolog) (Kelch family protein Nd1-L) (ND1-L2) (Nd1-S) Ivns1abp Kiaa0850 Nd1 Nd1L Nd1S Ns1 Ns1bp Mus musculus (Mouse) TR39183_c1_g1_i3 Q9FKJ0 FK132_ARATH 6.00E-06 GO:0005634 nucleus IPR001810; IPR015916; IPR006652; F-box/kelch-repeat protein At5g60570 At5g60570 MUF9.20 Arabidopsis thaliana (Mouse-ear cress) TR39183_c1_g1_i4 Q9Y573 IPP_HUMAN 1.00E-58 GO:0003779; GO:0015629; GO:0005737 actin binding; actin cytoskeleton; cytoplasm IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR017096; IPR015915; IPR006652; Actin-binding protein IPP (Intracisternal A particle-promoted polypeptide) (IPP) (Kelch-like protein 27) IPP KLHL27 Homo sapiens (Human) TR39183_c1_g1_i5 Q96PQ7 KLHL5_HUMAN 3.00E-44 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR006652; Kelch-like protein 5 KLHL5 Homo sapiens (Human) TR39183_c1_g2_i1 P28575 IPP_MOUSE 6.00E-59 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Actin-binding protein IPP (Intracisternal A particle-promoted polypeptide) (IPP) (Murine IAP-promoted placenta-expressed protein) (Protein MIPP) Ipp Mipp Mus musculus (Mouse) TR39183_c1_g2_i2 P17789 TTKB_DROME 5.00E-09 GO:0031208; GO:0048053; GO:0045467; GO:0000978; GO:0001078; GO:0000980; GO:0007298; GO:0048854; GO:0035147; GO:0001709; GO:0040003; GO:0003682; GO:0042675; GO:0048750; GO:0048813; GO:0046843; GO:0035001; GO:0007476; GO:0002121; GO:0031987; GO:0046872; GO:0007422; GO:0005700; GO:0043388; GO:0045944; GO:0042803; GO:0042682; GO:0016476; GO:0035151; GO:0001964; GO:0007426; GO:0017053 Q0E8J0 "POZ domain binding; R1/R6 development; R7 cell development; RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II distal enhancer sequence-specific DNA binding; border follicle cell migration; brain morphogenesis; branch fusion, open tracheal system; cell fate determination; chitin-based cuticle development; chromatin binding; compound eye cone cell differentiation; compound eye corneal lens morphogenesis; dendrite morphogenesis; dorsal appendage formation; dorsal trunk growth, open tracheal system; imaginal disc-derived wing morphogenesis; inter-male aggressive behavior; locomotion involved in locomotory behavior; metal ion binding; peripheral nervous system development; polytene chromosome; positive regulation of DNA binding; positive regulation of transcription from RNA polymerase II promoter; protein homodimerization activity; regulation of compound eye cone cell fate specification; regulation of embryonic cell shape; regulation of tube size, open tracheal system; startle response; tracheal outgrowth, open tracheal system; transcriptional repressor complex" IPR017956; IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; "Protein tramtrack, beta isoform (Repressor protein fushi tarazu) (Tramtrack p69)" ttk FTZ-F2 CG1856 Drosophila melanogaster (Fruit fly) TR39185_c1_g2_i1 A2QWM4 PMIP_ASPNC 2.00E-14 GO:0046872; GO:0004222; GO:0005759; GO:0006508 metal ion binding; metalloendopeptidase activity; mitochondrial matrix; proteolysis IPR024079; IPR024077; IPR001567; Mitochondrial intermediate peptidase (MIP) (EC 3.4.24.59) (Octapeptidyl aminopeptidase) oct1 An11g05710 Aspergillus niger (strain CBS 513.88 / FGSC A1513) TR39185_c1_g2_i3 P44573 OPDA_HAEIN 8.00E-49 GO:0046872; GO:0004222; GO:0006508 metal ion binding; metalloendopeptidase activity; proteolysis IPR024079; IPR024077; IPR024080; IPR001567; Oligopeptidase A (EC 3.4.24.70) prlC HI_0214 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) TR39186_c0_g1_i1 Q0V8S0 HGS_BOVIN 4.00E-158 GO:0031901; GO:0016197; GO:0006886; GO:0046872; GO:0032585; GO:0046426 early endosome membrane; endosomal transport; intracellular protein transport; metal ion binding; multivesicular body membrane; negative regulation of JAK-STAT cascade IPR008942; IPR027426; IPR024641; IPR017073; IPR003903; IPR002014; IPR018205; IPR000306; IPR017455; IPR011011; IPR013083; Hepatocyte growth factor-regulated tyrosine kinase substrate HGS Bos taurus (Bovine) TR39186_c0_g1_i2 Q9JJ50 HGS_RAT 2.00E-156 GO:0005829; GO:0031901; GO:0008333; GO:0006886; GO:0016020; GO:0046872; GO:0032585; GO:0046426; GO:0019904; GO:0030141 cytosol; early endosome membrane; endosome to lysosome transport; intracellular protein transport; membrane; metal ion binding; multivesicular body membrane; negative regulation of JAK-STAT cascade; protein domain specific binding; secretory granule IPR008942; IPR027426; IPR024641; IPR017073; IPR003903; IPR002014; IPR018205; IPR000306; IPR017455; IPR011011; IPR013083; Hepatocyte growth factor-regulated tyrosine kinase substrate (SNAP-25-interacting protein Hrs-2) Hgs Hrs Hrs2 Rattus norvegicus (Rat) TR39189_c0_g1_i1 Q9UHD2 TBK1_HUMAN 2.00E-124 GO:0005524; GO:0007249; GO:0035666; GO:0005829; GO:0050830; GO:0051607; GO:0010008; GO:0006954; GO:0045087; GO:0019048; GO:0010629; GO:0032480; GO:0003676; GO:0043123; GO:0032727; GO:0045359; GO:0032728; GO:0033138; GO:0045944; GO:0004674; GO:0009615; GO:0034138; GO:0034142; GO:0032606 K7Y1A2; P27958; Q9UKV8; Q7Z3C6; Q13137; Q6DT37; Q9BZA4; Q62167; Q14164; Q14653; Q92985; Q86YT6; Q96AX9; Q9NVV4; Q96CV9; P42226; Q92844; A7MCY6; Q86WV6; P40222; Q8BHN1 ATP binding; I-kappaB kinase/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; cytosol; defense response to Gram-positive bacterium; defense response to virus; endosome membrane; inflammatory response; innate immune response; modulation by virus of host morphology or physiology; negative regulation of gene expression; negative regulation of type I interferon production; nucleic acid binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon-alpha production; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein serine/threonine kinase activity; response to virus; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; type I interferon production IPR011009; IPR000719; IPR017441; Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) TBK1 NAK Homo sapiens (Human) TR39189_c0_g1_i2 Q9UHD2 TBK1_HUMAN 3.00E-124 GO:0005524; GO:0007249; GO:0035666; GO:0005829; GO:0050830; GO:0051607; GO:0010008; GO:0006954; GO:0045087; GO:0019048; GO:0010629; GO:0032480; GO:0003676; GO:0043123; GO:0032727; GO:0045359; GO:0032728; GO:0033138; GO:0045944; GO:0004674; GO:0009615; GO:0034138; GO:0034142; GO:0032606 K7Y1A2; P27958; Q9UKV8; Q7Z3C6; Q13137; Q6DT37; Q9BZA4; Q62167; Q14164; Q14653; Q92985; Q86YT6; Q96AX9; Q9NVV4; Q96CV9; P42226; Q92844; A7MCY6; Q86WV6; P40222; Q8BHN1 ATP binding; I-kappaB kinase/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; cytosol; defense response to Gram-positive bacterium; defense response to virus; endosome membrane; inflammatory response; innate immune response; modulation by virus of host morphology or physiology; negative regulation of gene expression; negative regulation of type I interferon production; nucleic acid binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon-alpha production; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein serine/threonine kinase activity; response to virus; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; type I interferon production IPR011009; IPR000719; IPR017441; Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) TBK1 NAK Homo sapiens (Human) TR39190_c1_g1_i3 Q6PF21 SYMC_XENLA 0 GO:0005524; GO:0005737; GO:0004825; GO:0006431; GO:0000049 ATP binding; cytoplasm; methionine-tRNA ligase activity; methionyl-tRNA aminoacylation; tRNA binding IPR001412; IPR010987; IPR023458; IPR014758; IPR015413; IPR014729; IPR009068; IPR009080; IPR000738; "Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)" mars Xenopus laevis (African clawed frog) TR39191_c3_g1_i2 Q9MYM7 B3GT1_PONPY 7.00E-37 GO:0000139; GO:0008378; GO:0016021; GO:0006486 Golgi membrane; galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) TR39191_c3_g1_i4 Q9Z0F0 B3GT4_MOUSE 1.00E-14 GO:0000139; GO:0047915; GO:0016021; GO:0006486 Golgi membrane; ganglioside galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 4 (Beta-1,3-GalTase 4) (Beta3Gal-T4) (Beta3GalT4) (b3Gal-T4) (EC 2.4.1.62) (Gal-T2) (Ganglioside galactosyltransferase) (UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase)" B3galt4 Mus musculus (Mouse) TR39192_c1_g2_i1 Q80VP5 CL065_MOUSE 3.00E-25 GO:0005739; GO:0003747 mitochondrion; translation release factor activity IPR014720; IPR000352; "Probable peptide chain release factor C12orf65 homolog, mitochondrial" Mus musculus (Mouse) TR39192_c1_g3_i1 P53370 NUDT6_HUMAN 7.00E-26 GO:0008083; GO:0016787; GO:0005739; GO:0005634 growth factor activity; hydrolase activity; mitochondrion; nucleus IPR003293; IPR020084; IPR000086; IPR015797; Nucleoside diphosphate-linked moiety X motif 6 (Nudix motif 6) (EC 3.6.1.-) (Antisense basic fibroblast growth factor) (Protein GFG) NUDT6 FGF2AS Homo sapiens (Human) TR39192_c1_g3_i2 Q8L7W2 NUDT8_ARATH 4.00E-29 GO:0016787; GO:0046872; GO:0009611 hydrolase activity; metal ion binding; response to wounding IPR003293; IPR020084; IPR000086; IPR015797; Nudix hydrolase 8 (AtNUDT8) (EC 3.6.1.-) NUDT8 NUDX8 At5g47240 MQL5.10 Arabidopsis thaliana (Mouse-ear cress) TR39195_c1_g1_i1 Q9CZJ2 HS12B_MOUSE 1.00E-48 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR39195_c1_g2_i2 Q96MM6 HS12B_HUMAN 2.00E-40 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR39195_c1_g2_i4 O43301 HS12A_HUMAN 3.00E-36 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR39195_c1_g2_i5 Q96MM6 HS12B_HUMAN 1.00E-51 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR39196_c0_g2_i1 Q8CE33 KLH11_MOUSE 5.00E-19 IPR011705; IPR000210; IPR011333; IPR013069; IPR015915; IPR006652; Kelch-like protein 11 Klhl11 Mus musculus (Mouse) TR39196_c0_g2_i2 Q0D2K2 KLH30_HUMAN 2.00E-24 IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 30 KLHL30 Homo sapiens (Human) TR39198_c0_g2_i3 O07552 NHAX_BACSU 1.00E-06 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Stress response protein NhaX nhaX yheK BSU09690 Bacillus subtilis (strain 168) TR39198_c0_g2_i4 Q57951 Y531_METJA 7.00E-07 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein MJ0531 (USP MJ0531) MJ0531 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR39199_c1_g1_i1 Q10983 FUT2_RABIT 5.00E-37 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Secretor blood group alpha-2-fucosyltransferase)" FUT2 RFT-II SEC1 Oryctolagus cuniculus (Rabbit) TR39199_c1_g1_i2 Q10983 FUT2_RABIT 3.00E-37 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Secretor blood group alpha-2-fucosyltransferase)" FUT2 RFT-II SEC1 Oryctolagus cuniculus (Rabbit) TR39199_c1_g1_i3 Q9TTC7 FUT2_HYLLA 1.00E-35 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2)" FUT2 Hylobates lar (Common gibbon) (White-handed gibbon) TR39199_c1_g1_i5 O77487 FUT2_PONPY 2.00E-36 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2)" FUT2 Pongo pygmaeus (Bornean orangutan) TR39199_c1_g1_i7 Q10984 FUT2_RAT 8.00E-35 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha 1,2-fucosyltransferase) (Alpha 1,2-fucosyltransferase B) (Alpha 1-2 fucosyltransferase) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Secretor blood group alpha-2-fucosyltransferase)" Fut2 Ftb Sec1 Rattus norvegicus (Rat) TR39200_c1_g1_i2 Q9ER75 IRX6_MOUSE 2.00E-38 GO:0005634; GO:0043565; GO:0003700 nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR017970; IPR001356; IPR008422; IPR009057; IPR003893; Iroquois-class homeodomain protein IRX-6 (Homeodomain protein IRXB3) (Iroquois homeobox protein 6) Irx6 Irxb3 Mus musculus (Mouse) TR39201_c1_g1_i4 P79145 CREM_CANFA 6.00E-46 GO:0006687; GO:0005634; GO:0045944; GO:0043565; GO:0003700; GO:0007283; GO:0005667; GO:0006351 "glycosphingolipid metabolic process; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; spermatogenesis; transcription factor complex; transcription, DNA-dependent" IPR004827; IPR003102; IPR001630; cAMP-responsive element modulator CREM Canis familiaris (Dog) (Canis lupus familiaris) TR39201_c1_g1_i6 P79145 CREM_CANFA 9.00E-46 GO:0006687; GO:0005634; GO:0045944; GO:0043565; GO:0003700; GO:0007283; GO:0005667; GO:0006351 "glycosphingolipid metabolic process; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; spermatogenesis; transcription factor complex; transcription, DNA-dependent" IPR004827; IPR003102; IPR001630; cAMP-responsive element modulator CREM Canis familiaris (Dog) (Canis lupus familiaris) TR39202_c1_g1_i1 Q7L7X3 TAOK1_HUMAN 7.00E-53 GO:0005524; GO:0006281; GO:0031572; GO:0005829; GO:0097194; GO:0000278; GO:0046330; GO:0004674; GO:0051493 ATP binding; DNA repair; G2 DNA damage checkpoint; cytosol; execution phase of apoptosis; mitotic cell cycle; positive regulation of JNK cascade; protein serine/threonine kinase activity; regulation of cytoskeleton organization IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) TAOK1 KIAA1361 MAP3K16 MARKK Homo sapiens (Human) TR39202_c3_g2_i1 Q9JLS3 TAOK2_RAT 4.00E-90 GO:0005524; GO:0031572; GO:0004709; GO:0030659; GO:0005856; GO:0030425; GO:0016021; GO:0032874; GO:0051403 ATP binding; G2 DNA damage checkpoint; MAP kinase kinase kinase activity; cytoplasmic vesicle membrane; cytoskeleton; dendrite; integral to membrane; positive regulation of stress-activated MAPK cascade; stress-activated MAPK cascade IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) Taok2 Tao2 Rattus norvegicus (Rat) TR39202_c4_g1_i1 Q5U263 KDM2A_XENTR 6.00E-20 GO:0003677; GO:0070544; GO:0051864; GO:0005654; GO:0006355; GO:0006351; GO:0008270 "DNA binding; histone H3-K36 demethylation; histone demethylase activity (H3-K36 specific); nucleoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003347; IPR019786; IPR002857; IPR011011; IPR001965; IPR019787; IPR013083; Lysine-specific demethylase 2A (EC 1.14.11.27) (F-box and leucine-rich repeat protein 11) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) kdm2a fbxl11 jhdm1a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39202_c4_g3_i1 Q5F2E8 TAOK1_MOUSE 1.00E-91 GO:0005524; GO:0006281; GO:0031572; GO:0005737; GO:0097194; GO:0046330; GO:0004674; GO:0051493 ATP binding; DNA repair; G2 DNA damage checkpoint; cytoplasm; execution phase of apoptosis; positive regulation of JNK cascade; protein serine/threonine kinase activity; regulation of cytoskeleton organization IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) Taok1 Kiaa1361 Mus musculus (Mouse) TR39203_c0_g1_i1 Q08D69 MED16_XENTR 4.00E-112 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR021665; IPR015943; IPR001680; IPR017986; Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16) med16 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39204_c2_g1_i1 Q6P7G6 BRK1A_XENLA 1.00E-32 GO:0005737; GO:0005856 cytoplasm; cytoskeleton Probable protein BRICK1-A brk1-a Xenopus laevis (African clawed frog) TR39205_c1_g1_i1 Q9D939 ST1C2_MOUSE 6.00E-38 GO:0005764; GO:0008146 lysosome; sulfotransferase activity IPR027417; IPR000863; Sulfotransferase 1C2 (ST1C2) (EC 2.8.2.-) Sult1c2 Sult1c1 Mus musculus (Mouse) TR39205_c1_g1_i2 P19217 ST1E1_BOVIN 1.00E-33 GO:0005737; GO:0008210; GO:0004304; GO:0005496; GO:0050294 cytoplasm; estrogen metabolic process; estrone sulfotransferase activity; steroid binding; steroid sulfotransferase activity IPR027417; IPR000863; "Estrogen sulfotransferase (EC 2.8.2.4) (Sulfotransferase 1E1) (ST1E1) (Sulfotransferase, estrogen-preferring)" SULT1E1 OST STE Bos taurus (Bovine) TR39205_c1_g1_i3 P50224 ST1A3_HUMAN 8.00E-36 GO:0050427; GO:0006987; GO:0004062; GO:0006584; GO:0044267; GO:0005829; GO:0009812; GO:0008202; GO:0051923; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; activation of signaling protein activity involved in unfolded protein response; aryl sulfotransferase activity; catecholamine metabolic process; cellular protein metabolic process; cytosol; flavonoid metabolic process; steroid metabolic process; sulfation; xenobiotic metabolic process IPR027417; IPR000863; "Sulfotransferase 1A3/1A4 (ST1A3/ST1A4) (EC 2.8.2.1) (Aryl sulfotransferase 1A3/1A4) (Catecholamine-sulfating phenol sulfotransferase) (HAST3) (M-PST) (Monoamine-sulfating phenol sulfotransferase) (Placental estrogen sulfotransferase) (Sulfotransferase, monoamine-preferring) (Thermolabile phenol sulfotransferase) (TL-PST)" SULT1A3 STM; SULT1A4 Homo sapiens (Human) TR39205_c1_g1_i4 O35400 ST2B1_MOUSE 1.00E-31 GO:0004027; GO:0005783; GO:0008202; GO:0050294; GO:0000103; GO:0008146 alcohol sulfotransferase activity; endoplasmic reticulum; steroid metabolic process; steroid sulfotransferase activity; sulfate assimilation; sulfotransferase activity IPR027417; IPR000863; Sulfotransferase family cytosolic 2B member 1 (ST2B1) (Sulfotransferase 2B1) (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2) Sult2b1 Sult2b Mus musculus (Mouse) TR39206_c1_g1_i1 O35840 LCAT_TATKG 3.00E-57 GO:0008203; GO:0005576; GO:0004607 cholesterol metabolic process; extracellular region; phosphatidylcholine-sterol O-acyltransferase activity IPR003386; Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase) (Fragment) LCAT Tatera kempi gambiana (Kemp's gerbil) (Tatera gambiana) TR39206_c1_g1_i2 Q8NCC3 PAG15_HUMAN 2.00E-117 GO:0008374; GO:0047499; GO:0006672; GO:0005576; GO:0009062; GO:0004622; GO:0005764; GO:0005739; GO:0046470; GO:0005543 O-acyltransferase activity; calcium-independent phospholipase A2 activity; ceramide metabolic process; extracellular region; fatty acid catabolic process; lysophospholipase activity; lysosome; mitochondrion; phosphatidylcholine metabolic process; phospholipid binding IPR003386; Group XV phospholipase A2 (EC 2.3.1.-) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) PLA2G15 LYPLA3 UNQ341/PRO540 Homo sapiens (Human) TR39206_c1_g1_i4 Q8VEB4 PAG15_MOUSE 7.00E-56 GO:0008374; GO:0047499; GO:0006672; GO:0005576; GO:0006631; GO:0005764; GO:0005739; GO:0046470 O-acyltransferase activity; calcium-independent phospholipase A2 activity; ceramide metabolic process; extracellular region; fatty acid metabolic process; lysosome; mitochondrion; phosphatidylcholine metabolic process IPR003386; Group XV phospholipase A2 (EC 2.3.1.-) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) Pla2g15 Lypla3 Mus musculus (Mouse) TR39206_c1_g1_i5 O35724 LCAT_MICMN 2.00E-26 GO:0008203; GO:0005576; GO:0004607 cholesterol metabolic process; extracellular region; phosphatidylcholine-sterol O-acyltransferase activity IPR003386; Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase) (Fragment) LCAT Micromys minutus (European harvest mouse) TR39206_c1_g1_i7 O35573 LCAT_ELIQU 1.00E-27 GO:0008203; GO:0005576; GO:0004607 cholesterol metabolic process; extracellular region; phosphatidylcholine-sterol O-acyltransferase activity IPR003386; Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase) (Fragment) LCAT Eliomys quercinus (Garden dormouse) TR39208_c1_g1_i1 Q9UF02 CCG5_HUMAN 4.00E-11 GO:0032281; GO:0030054; GO:0014069; GO:0045211; GO:2000311; GO:0005245 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; cell junction; postsynaptic density; postsynaptic membrane; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; voltage-gated calcium channel activity IPR004031; IPR008369; IPR008368; Voltage-dependent calcium channel gamma-5 subunit (Neuronal voltage-gated calcium channel gamma-5 subunit) (Transmembrane AMPAR regulatory protein gamma-5) (TARP gamma-5) CACNG5 Homo sapiens (Human) TR39208_c1_g1_i5 Q9UF02 CCG5_HUMAN 5.00E-12 GO:0032281; GO:0030054; GO:0014069; GO:0045211; GO:2000311; GO:0005245 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; cell junction; postsynaptic density; postsynaptic membrane; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; voltage-gated calcium channel activity IPR004031; IPR008369; IPR008368; Voltage-dependent calcium channel gamma-5 subunit (Neuronal voltage-gated calcium channel gamma-5 subunit) (Transmembrane AMPAR regulatory protein gamma-5) (TARP gamma-5) CACNG5 Homo sapiens (Human) TR39208_c1_g1_i8 Q71RJ2 CCG2_RAT 1.00E-07 GO:0032281; GO:0005246; GO:0051899; GO:0060081; GO:0007528; GO:2000311; GO:0019226; GO:0005245; GO:0005891 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; calcium channel regulator activity; membrane depolarization; membrane hyperpolarization; neuromuscular junction development; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; transmission of nerve impulse; voltage-gated calcium channel activity; voltage-gated calcium channel complex IPR004031; IPR005422; IPR008368; Voltage-dependent calcium channel gamma-2 subunit (Neuronal voltage-gated calcium channel gamma-2 subunit) (Transmembrane AMPAR regulatory protein gamma-2) (TARP gamma-2) Cacng2 Rattus norvegicus (Rat) TR39210_c0_g1_i1 Q2U5T5 VAC8_ASPOR 6.00E-10 GO:0071255; GO:0071563; GO:0000329; GO:0016236; GO:0071561; GO:0071562; GO:0042144; GO:0000011 "CVT vesicle assembly; Myo2p-Vac17p-Vac8p transport complex; fungal-type vacuole membrane; macroautophagy; nucleus-vacuole junction; nucleus-vacuole junction assembly; vacuole fusion, non-autophagic; vacuole inheritance" IPR011989; IPR016024; IPR000225; IPR026958; Vacuolar protein 8 vac8 AO090113000014 Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) TR39210_c0_g1_i2 P35224 CTNB_URECA 0 GO:0007155; GO:0005737; GO:0005856 cell adhesion; cytoplasm; cytoskeleton IPR011989; IPR016024; IPR000225; IPR013284; Catenin beta (Beta-catenin) Urechis caupo (Innkeeper worm) (Spoonworm) TR39210_c0_g1_i3 P35224 CTNB_URECA 0 GO:0007155; GO:0005737; GO:0005856 cell adhesion; cytoplasm; cytoskeleton IPR011989; IPR016024; IPR000225; IPR013284; Catenin beta (Beta-catenin) Urechis caupo (Innkeeper worm) (Spoonworm) TR39211_c3_g1_i1 Q8MJC3 CASP3_RABIT 2.00E-16 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Oryctolagus cuniculus (Rabbit) TR39211_c3_g1_i2 Q5IS99 CASP3_SAIBB 1.00E-18 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Saimiri boliviensis boliviensis (Bolivian squirrel monkey) TR39211_c3_g1_i3 Q5IS99 CASP3_SAIBB 2.00E-19 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Saimiri boliviensis boliviensis (Bolivian squirrel monkey) TR39211_c3_g1_i6 P97864 CASP7_MOUSE 3.00E-18 GO:0004190; GO:0097153; GO:0005737; GO:0097194; GO:0007507; GO:0005634; GO:0043525; GO:0016485; GO:0006508; GO:0001836; GO:0009411 P11103; P62270 aspartic-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cytoplasm; execution phase of apoptosis; heart development; nucleus; positive regulation of neuron apoptotic process; protein processing; proteolysis; release of cytochrome c from mitochondria; response to UV IPR015471; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; "Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11; Caspase-7, N-terminally processed]" Casp7 Lice2 Mch3 Mus musculus (Mouse) TR39212_c0_g2_i4 Q8K0U4 HS12A_MOUSE 2.00E-50 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR39212_c0_g2_i5 Q8K0U4 HS12A_MOUSE 1.00E-50 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR39214_c6_g1_i1 Q54271 PPD_STRHY 3.00E-52 GO:0017000; GO:0032923; GO:0033980; GO:0030976 antibiotic biosynthetic process; organic phosphonate biosynthetic process; phosphonopyruvate decarboxylase activity; thiamine pyrophosphate binding IPR017684; IPR012001; IPR011766; Secondary metabolite biosynthesis; bialaphos biosynthesis. Phosphonopyruvate decarboxylase (EC 4.1.1.82) bcpC Streptomyces hygroscopicus TR39214_c6_g1_i2 P58415 COMD_METJA 7.00E-10 GO:0019295; GO:0050545; GO:0030976 coenzyme M biosynthetic process; sulfopyruvate decarboxylase activity; thiamine pyrophosphate binding IPR022502; IPR012001; Cofactor biosynthesis; coenzyme M biosynthesis; sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 4/4. Sulfopyruvate decarboxylase subunit alpha (EC 4.1.1.79) comD MJ0255.1 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR39214_c6_g1_i3 Q8TKU6 COMDE_METAC 1.00E-21 GO:0019295; GO:0050545; GO:0030976 coenzyme M biosynthetic process; sulfopyruvate decarboxylase activity; thiamine pyrophosphate binding IPR022502; IPR022494; IPR012001; IPR011766; Cofactor biosynthesis; coenzyme M biosynthesis. Sulfopyruvate decarboxylase (SpyrDC) (EC 4.1.1.79) comDE MA_3298 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) TR39214_c6_g1_i4 Q54271 PPD_STRHY 3.00E-52 GO:0017000; GO:0032923; GO:0033980; GO:0030976 antibiotic biosynthetic process; organic phosphonate biosynthetic process; phosphonopyruvate decarboxylase activity; thiamine pyrophosphate binding IPR017684; IPR012001; IPR011766; Secondary metabolite biosynthesis; bialaphos biosynthesis. Phosphonopyruvate decarboxylase (EC 4.1.1.82) bcpC Streptomyces hygroscopicus TR39215_c3_g3_i1 Q9H490 PIGU_HUMAN 2.00E-113 GO:0006501; GO:0042765; GO:0016255; GO:0005886; GO:0046425 C-terminal protein lipidation; GPI-anchor transamidase complex; attachment of GPI anchor to protein; plasma membrane; regulation of JAK-STAT cascade IPR009600; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Phosphatidylinositol glycan anchor biosynthesis class U protein (Cell division cycle protein 91-like 1) (Protein CDC91-like 1) (GPI transamidase component PIG-U) PIGU CDC91L1 PSEC0205 UNQ3055/PRO9875 Homo sapiens (Human) TR39216_c1_g2_i3 Q3T046 BDH2_BOVIN 5.00E-85 GO:0003858; GO:0005737; GO:0042168; GO:0055072; GO:0016628; GO:0019290 "3-hydroxybutyrate dehydrogenase activity; cytoplasm; heme metabolic process; iron ion homeostasis; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; siderophore biosynthetic process" IPR002198; IPR002347; IPR016040; IPR020904; Siderophore biosynthesis. 3-hydroxybutyrate dehydrogenase type 2 (EC 1.1.1.-) (EC 1.1.1.30) (Dehydrogenase/reductase SDR family member 6) (R-beta-hydroxybutyrate dehydrogenase) BDH2 DHRS6 Bos taurus (Bovine) TR39216_c1_g2_i5 Q3KPT7 BDH2_XENLA 2.00E-88 GO:0003858; GO:0005737; GO:0042168; GO:0055072; GO:0016628; GO:0019290 "3-hydroxybutyrate dehydrogenase activity; cytoplasm; heme metabolic process; iron ion homeostasis; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; siderophore biosynthetic process" IPR002198; IPR002347; IPR016040; IPR020904; Siderophore biosynthesis. 3-hydroxybutyrate dehydrogenase type 2 (EC 1.1.1.-) (EC 1.1.1.30) (R-beta-hydroxybutyrate dehydrogenase) bdh2 Xenopus laevis (African clawed frog) TR39216_c1_g2_i6 Q56841 HCDS_XANP2 8.00E-15 GO:0050575; GO:0042208 2-(S)-hydroxypropyl-CoM dehydrogenase activity; propylene catabolic process IPR002198; IPR002347; IPR016040; IPR020904; Alkene metabolism; propylene degradation. 2-(S)-hydroxypropyl-CoM dehydrogenase (S-HPCDH) (EC 1.1.1.269) (Aliphatic epoxide carboxylation component IV) xecE Xaut_4869 Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) TR39219_c1_g2_i1 P41932 14331_CAEEL 5.00E-117 GO:0045167; GO:0005938; GO:0001708; GO:0000132; GO:0030590; GO:0007126; GO:0005634; GO:0009949; GO:0035046; GO:0007346; GO:0010070 G5EC23; Q11184; Q10666; Q21921 asymmetric protein localization involved in cell fate determination; cell cortex; cell fate specification; establishment of mitotic spindle orientation; first cell cycle pseudocleavage; meiosis; nucleus; polarity specification of anterior/posterior axis; pronuclear migration; regulation of mitotic cell cycle; zygote asymmetric cell division IPR000308; IPR023409; IPR023410; 14-3-3-like protein 1 (Partitioning defective protein 5) par-5 ftt-1 M117.2 Caenorhabditis elegans TR39219_c1_g2_i2 P68251 1433B_SHEEP 2.00E-59 GO:0042470 melanosome IPR000308; IPR023409; IPR023410; "14-3-3 protein beta/alpha (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] (Fragments)" YWHAB Ovis aries (Sheep) TR3922_c0_g1_i1 Q9H5I5 PIEZ2_HUMAN 2.00E-19 GO:0005261; GO:0006812; GO:0016021; GO:0008381; GO:0042391 cation channel activity; cation transport; integral to membrane; mechanically-gated ion channel activity; regulation of membrane potential IPR027272; Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) PIEZO2 C18orf30 C18orf58 FAM38B Homo sapiens (Human) TR39220_c0_g1_i1 P19882 HSP60_YEAST 0 GO:0006458; GO:0005524; GO:0016887; GO:0003688; GO:0051131; GO:0005829; GO:0005743; GO:0005758; GO:0042645; GO:0045041; GO:0051604; GO:0042026; GO:0050821; GO:0006950; GO:0003697; GO:0051082 'de novo' protein folding; ATP binding; ATPase activity; DNA replication origin binding; chaperone-mediated protein complex assembly; cytosol; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial nucleoid; protein import into mitochondrial intermembrane space; protein maturation; protein refolding; protein stabilization; response to stress; single-stranded DNA binding; unfolded protein binding IPR018370; IPR001844; IPR002423; IPR027409; IPR027413; "Heat shock protein 60, mitochondrial (CPN60) (P66) (Stimulator factor I 66 kDa component)" HSP60 MIF4 YLR259C L8479.10 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39220_c0_g1_i2 Q5ZL72 CH60_CHICK 0 GO:0005524; GO:0002368; GO:0042100; GO:0002755; GO:0006919; GO:0009986; GO:0005905; GO:0030135; GO:0019907; GO:0005829; GO:0005769; GO:0005615; GO:0048291; GO:0046696; GO:0005759; GO:0043066; GO:0050870; GO:0002842; GO:0043065; GO:0032733; GO:0032735; GO:0032755; GO:0043032; GO:0042026; GO:0006986 Q8AYS8 ATP binding; B cell cytokine production; B cell proliferation; MyD88-dependent toll-like receptor signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; cell surface; coated pit; coated vesicle; cyclin-dependent protein kinase activating kinase holoenzyme complex; cytosol; early endosome; extracellular space; isotype switching to IgG isotypes; lipopolysaccharide receptor complex; mitochondrial matrix; negative regulation of apoptotic process; positive regulation of T cell activation; positive regulation of T cell mediated immune response to tumor cell; positive regulation of apoptotic process; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of macrophage activation; protein refolding; response to unfolded protein IPR018370; IPR001844; IPR002423; IPR027409; IPR027413; "60 kDa heat shock protein, mitochondrial (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60)" HSPD1 HSP60 RCJMB04_7g5 Gallus gallus (Chicken) TR39221_c1_g2_i1 Q94K73 SYFM_ARATH 2.00E-13 GO:0005524; GO:0009570; GO:0000287; GO:0016020; GO:0005759; GO:0005739; GO:0004826; GO:0006432; GO:0000049; GO:0008033 ATP binding; chloroplast stroma; magnesium ion binding; membrane; mitochondrial matrix; mitochondrion; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding; tRNA processing IPR006195; IPR004530; IPR002319; IPR005121; "Phenylalanine--tRNA ligase, chloroplastic/mitochondrial (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase) (PheRS)" At3g58140 F9D24.50 Arabidopsis thaliana (Mouse-ear cress) TR39221_c1_g2_i2 Q3UY23 FDXA1_MOUSE 2.00E-16 GO:0005524; GO:0000287; GO:0004826; GO:0006432; GO:0000049; GO:0008033 ATP binding; magnesium ion binding; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding; tRNA processing IPR019446; IPR005121; Ferredoxin-fold anticodon-binding domain-containing protein 1 homolog (FDX-ACDB domain-containing protein 1) Fdxacb1 Mus musculus (Mouse) TR39223_c0_g1_i1 O14772 FPGT_HUMAN 4.00E-14 GO:0005525; GO:0003824; GO:0005737; GO:0006004; GO:0047341 GTP binding; catalytic activity; cytoplasm; fucose metabolic process; fucose-1-phosphate guanylyltransferase activity IPR012887; IPR012120; IPR011004; Fucose-1-phosphate guanylyltransferase (EC 2.7.7.30) (GDP-L-fucose diphosphorylase) (GDP-L-fucose pyrophosphorylase) FPGT GFPP Homo sapiens (Human) TR39223_c0_g2_i3 Q9LNJ9 FKGP_ARATH 1.00E-12 GO:0005524; GO:0042352; GO:0005975; GO:0005737; GO:0050201; GO:0047341; GO:0046872 ATP binding; GDP-L-fucose salvage; carbohydrate metabolic process; cytoplasm; fucokinase activity; fucose-1-phosphate guanylyltransferase activity; metal ion binding IPR012887; IPR013750; IPR006204; IPR006206; IPR020568; IPR014721; Bifunctional fucokinase/fucose pyrophosphorylase (AtFKGP) [Includes: L-fucokinase (EC 2.7.1.52); Fucose-1-phosphate guanylyltransferase (EC 2.7.7.30) (GDP-fucose pyrophosphorylase)] FKGP At1g01220 F6F3.3 Arabidopsis thaliana (Mouse-ear cress) TR39223_c0_g2_i4 O14772 FPGT_HUMAN 7.00E-61 GO:0005525; GO:0003824; GO:0005737; GO:0006004; GO:0047341 GTP binding; catalytic activity; cytoplasm; fucose metabolic process; fucose-1-phosphate guanylyltransferase activity IPR012887; IPR012120; IPR011004; Fucose-1-phosphate guanylyltransferase (EC 2.7.7.30) (GDP-L-fucose diphosphorylase) (GDP-L-fucose pyrophosphorylase) FPGT GFPP Homo sapiens (Human) TR39224_c1_g1_i1 A5GFW7 CT043_PIG 6.00E-76 IPR006735; IPR027799; Protein RTF2 homolog (Replication termination factor 2 domain-containing protein 1) RTFDC1 Sus scrofa (Pig) TR39224_c1_g1_i2 Q5R9P9 CT043_PONAB 6.00E-79 IPR006735; IPR027799; Protein RTF2 homolog (Replication termination factor 2 domain-containing protein 1) RTFDC1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39226_c0_g1_i2 Q2KJE0 TAXB1_BOVIN 2.00E-46 GO:0006915; GO:0032088 apoptotic process; negative regulation of NF-kappaB transcription factor activity IPR012852; IPR015880; Tax1-binding protein 1 homolog TAX1BP1 Bos taurus (Bovine) TR39229_c1_g1_i1 Q6AYJ2 BOD1_RAT 5.00E-38 GO:0051301; GO:0000777; GO:0005737; GO:0005815; GO:0007067 cell division; condensed chromosome kinetochore; cytoplasm; microtubule organizing center; mitosis IPR026955; Biorientation of chromosomes in cell division protein 1 (Biorientation defective protein 1) (Protein FAM44B) Bod1 Fam44b Rattus norvegicus (Rat) TR39229_c3_g1_i1 Q4P9T3 CCR4_USTMA 1.00E-117 GO:0003723; GO:0005737; GO:0046872; GO:0090305; GO:0005634; GO:0004535; GO:0006355; GO:0006351 "RNA binding; cytoplasm; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleus; poly(A)-specific ribonuclease activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR005135; IPR001611; IPR025875; IPR003591; Glucose-repressible alcohol dehydrogenase transcriptional effector (EC 3.1.13.4) (Carbon catabolite repressor protein 4) (Cytoplasmic deadenylase) CCR4 UM03130 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR39229_c3_g1_i2 Q8VEG6 CNO6L_MOUSE 0 GO:0030014; GO:0005737; GO:0031047; GO:0061157; GO:0006397; GO:0046872; GO:0000288; GO:0005634; GO:0004535; GO:0008284; GO:0010606; GO:0006355; GO:0006417; GO:0006351 Q60809 "CCR4-NOT complex; cytoplasm; gene silencing by RNA; mRNA destabilization; mRNA processing; metal ion binding; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; nucleus; poly(A)-specific ribonuclease activity; positive regulation of cell proliferation; positive regulation of cytoplasmic mRNA processing body assembly; regulation of transcription, DNA-dependent; regulation of translation; transcription, DNA-dependent" IPR005135; IPR001611; CCR4-NOT transcription complex subunit 6-like (EC 3.1.13.4) Cnot6l Mus musculus (Mouse) TR39229_c3_g1_i3 Q8VEG6 CNO6L_MOUSE 0 GO:0030014; GO:0005737; GO:0031047; GO:0061157; GO:0006397; GO:0046872; GO:0000288; GO:0005634; GO:0004535; GO:0008284; GO:0010606; GO:0006355; GO:0006417; GO:0006351 Q60809 "CCR4-NOT complex; cytoplasm; gene silencing by RNA; mRNA destabilization; mRNA processing; metal ion binding; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; nucleus; poly(A)-specific ribonuclease activity; positive regulation of cell proliferation; positive regulation of cytoplasmic mRNA processing body assembly; regulation of transcription, DNA-dependent; regulation of translation; transcription, DNA-dependent" IPR005135; IPR001611; CCR4-NOT transcription complex subunit 6-like (EC 3.1.13.4) Cnot6l Mus musculus (Mouse) TR39230_c1_g1_i1 Q9LHN8 F6H1_ARATH 5.00E-22 GO:0009805; GO:0051213; GO:0010421; GO:0046872; GO:0016706 "coumarin biosynthetic process; dioxygenase activity; hydrogen peroxide-mediated programmed cell death; metal ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" IPR026992; IPR027443; IPR005123; Feruloyl CoA ortho-hydroxylase 1 (EC 1.14.11.-) F6'H1 At3g13610 K20M4.5 Arabidopsis thaliana (Mouse-ear cress) TR39230_c1_g1_i2 Q9XG83 G2OX_PHACN 2.00E-16 GO:0045543; GO:0009686; GO:0005506 gibberellin 2-beta-dioxygenase activity; gibberellin biosynthetic process; iron ion binding IPR026992; IPR027443; IPR002283; IPR005123; Plant hormone biosynthesis; gibberellin biosynthesis. Gibberellin 2-beta-dioxygenase (EC 1.14.11.13) (GA 2-oxidase) (Gibberellin 2-beta-hydroxylase) (Gibberellin 2-oxidase) GA2OX1 Phaseolus coccineus (Scarlet runner bean) (Phaseolus multiflorus) TR39230_c1_g1_i3 Q54RA4 Y3291_DICDI 2.00E-23 GO:0005506; GO:0016706 "iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" IPR026992; IPR027443; IPR002283; IPR005123; Probable iron/ascorbate oxidoreductase DDB_G0283291 (EC 1.14.-.-) DDB_G0283291 Dictyostelium discoideum (Slime mold) TR39230_c1_g1_i4 Q7LL04 YQK1_SCHPO 4.00E-37 GO:0005829; GO:0005634; GO:0016706 "cytosol; nucleus; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" IPR026992; IPR027443; IPR005123; UPF0676 protein C1494.01 SPCC1494.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR39230_c1_g1_i5 O65378 ACCO3_ARATH 8.00E-22 GO:0009815; GO:0031418; GO:0071398; GO:0006952; GO:0009693; GO:0046872; GO:0016706 "1-aminocyclopropane-1-carboxylate oxidase activity; L-ascorbic acid binding; cellular response to fatty acid; defense response; ethylene biosynthetic process; metal ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" IPR026992; IPR027443; IPR005123; Alkene biosynthesis; ethylene biosynthesis via S-adenosyl-L-methionine; ethylene from S-adenosyl-L-methionine: step 2/2. 1-aminocyclopropane-1-carboxylate oxidase 3 (ACC oxidase 3) (AtACO3) (EC 1.14.17.4) At1g12010 F12F1.12 Arabidopsis thaliana (Mouse-ear cress) TR39231_c0_g1_i1 Q63844 MK03_MOUSE 1.00E-29 GO:0005524; GO:0030509; GO:0005794; GO:0004707; GO:0006915; GO:0051216; GO:0005901; GO:0072584; GO:0007049; GO:0071260; GO:0005856; GO:0005829; GO:0005769; GO:0005925; GO:0070498; GO:0005770; GO:0031663; GO:0005739; GO:2000657; GO:0005654; GO:0009887; GO:0038083; GO:0001784; GO:0070374; GO:0035066; GO:0033129; GO:0045944; GO:0031143; GO:0090170; GO:0051493; GO:2000641; GO:0051090; GO:0032872; GO:0006974; GO:0070849; GO:0043330; GO:0019233; GO:0006351 "ATP binding; BMP signaling pathway; Golgi apparatus; MAP kinase activity; apoptotic process; cartilage development; caveola; caveolin-mediated endocytosis; cell cycle; cellular response to mechanical stimulus; cytoskeleton; cytosol; early endosome; focal adhesion; interleukin-1-mediated signaling pathway; late endosome; lipopolysaccharide-mediated signaling pathway; mitochondrion; negative regulation of apolipoprotein binding; nucleoplasm; organ morphogenesis; peptidyl-tyrosine autophosphorylation; phosphotyrosine binding; positive regulation of ERK1 and ERK2 cascade; positive regulation of histone acetylation; positive regulation of histone phosphorylation; positive regulation of transcription from RNA polymerase II promoter; pseudopodium; regulation of Golgi inheritance; regulation of cytoskeleton organization; regulation of early endosome to late endosome transport; regulation of sequence-specific DNA binding transcription factor activity; regulation of stress-activated MAPK cascade; response to DNA damage stimulus; response to epidermal growth factor stimulus; response to exogenous dsRNA; sensory perception of pain; transcription, DNA-dependent" IPR011009; IPR003527; IPR008349; IPR000719; IPR017441; IPR002290; IPR008271; Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1) Mapk3 Erk1 Prkm3 Mus musculus (Mouse) TR39231_c0_g1_i2 Q00859 MAPK_FUSSO 2.00E-131 GO:0005524; GO:0004707; GO:0000165; GO:0005634 ATP binding; MAP kinase activity; MAPK cascade; nucleus IPR011009; IPR003527; IPR000719; IPR017441; IPR002290; IPR008271; Mitogen-activated protein kinase (EC 2.7.11.24) (FsMAPK) MAPK Fusarium solani subsp. pisi (Nectria haematococca) TR39231_c0_g1_i3 Q966Y3 JNK_SUBDO 5.00E-80 GO:0005524; GO:0007254; GO:0004707 ATP binding; JNK cascade; MAP kinase activity IPR011009; IPR003527; IPR008351; IPR000719; IPR002290; IPR008271; Stress-activated protein kinase JNK (EC 2.7.11.24) JNK Suberites domuncula (Sponge) TR39231_c0_g1_i4 A8XSC1 NLK_CAEBR 9.00E-55 GO:0005524; GO:0004707; GO:0000165; GO:0016055; GO:0005938; GO:0046872; GO:0007275; GO:0005634 ATP binding; MAP kinase activity; MAPK cascade; Wnt receptor signaling pathway; cell cortex; metal ion binding; multicellular organismal development; nucleus IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine kinase NLK (EC 2.7.11.24) (Loss of intestine protein 1) (Nemo-like kinase) lit-1 nlk CBG18286 Caenorhabditis briggsae TR39231_c0_g1_i5 P0CP66 CPK1_CRYNJ 6.00E-118 GO:0005524; GO:0004707; GO:0000165 ATP binding; MAP kinase activity; MAPK cascade IPR011009; IPR003527; IPR000719; IPR017441; IPR002290; IPR008271; Mitogen-activated protein kinase CPK1 (EC 2.7.11.24) (Stress-activated protein kinase CPK1) CPK1 CNE00520 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR39231_c0_g1_i6 P26696 MK01_XENLA 0 GO:0005524; GO:0004707; GO:0000165; GO:0006915; GO:0007049; GO:0005737; GO:0005815; GO:0005634; GO:0004674; GO:0070849; GO:0005819 ATP binding; MAP kinase activity; MAPK cascade; apoptotic process; cell cycle; cytoplasm; microtubule organizing center; nucleus; protein serine/threonine kinase activity; response to epidermal growth factor stimulus; spindle IPR011009; IPR003527; IPR008349; IPR000719; IPR017441; IPR002290; IPR008271; Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (M phase MAP kinase) (Myelin basic protein kinase) (MBP kinase) (Myelin xP42 protein kinase) mapk1 mpk1 Xenopus laevis (African clawed frog) TR39232_c0_g1_i1 B7S4N9 IVBTI_OXYSC 7.00E-14 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; "Taicatoxin, serine protease inhibitor component (TCX, serine protease inhibitor component) (TSPI) (Venom protease inhibitor 1) (Venom protease inhibitor 2)" Oxyuranus scutellatus scutellatus (Australian taipan) (Coastal taipan) TR39232_c0_g1_i2 B7S4N9 IVBTI_OXYSC 2.00E-14 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; "Taicatoxin, serine protease inhibitor component (TCX, serine protease inhibitor component) (TSPI) (Venom protease inhibitor 1) (Venom protease inhibitor 2)" Oxyuranus scutellatus scutellatus (Australian taipan) (Coastal taipan) TR39233_c0_g1_i1 Q80VY9 DHX33_MOUSE 0 GO:0005524; GO:0008026; GO:0005730; GO:0005654; GO:0045943; GO:0000182 ATP binding; ATP-dependent helicase activity; nucleolus; nucleoplasm; positive regulation of transcription from RNA polymerase I promoter; rDNA binding IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Putative ATP-dependent RNA helicase DHX33 (EC 3.6.4.13) (DEAH box protein 33) Dhx33 Mus musculus (Mouse) TR39234_c1_g1_i1 O60309 L37A3_HUMAN 1.00E-08 GO:0016021 integral to membrane IPR001611; IPR003591; IPR015753; Leucine-rich repeat-containing protein 37A3 LRRC37A3 KIAA0563 Homo sapiens (Human) TR39234_c1_g1_i2 Q91ZZ5 RXFP2_MOUSE 8.00E-08 GO:0007189; GO:0016021; GO:0008584; GO:0005886; GO:0016500 adenylate cyclase-activating G-protein coupled receptor signaling pathway; integral to membrane; male gonad development; plasma membrane; protein-hormone receptor activity IPR000276; IPR017452; IPR023415; IPR002172; IPR001611; IPR003591; IPR000372; IPR008112; Relaxin receptor 2 (G-protein coupled receptor 106) (G-protein coupled receptor affecting testicular descent) (Leucine-rich repeat-containing G-protein coupled receptor 8) (Relaxin family peptide receptor 2) Rxfp2 Gpr106 Great Lgr8 Mus musculus (Mouse) TR39234_c1_g1_i3 Q91W20 LRC26_MOUSE 8.00E-12 GO:0005737; GO:0005856; GO:0006811; GO:0015459; GO:0008076 cytoplasm; cytoskeleton; ion transport; potassium channel regulator activity; voltage-gated potassium channel complex IPR000483; IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing protein 26 (BK channel auxiliary gamma subunit LRRC26) Lrrc26 Mus musculus (Mouse) TR39234_c1_g1_i4 O94898 LRIG2_HUMAN 5.00E-11 GO:0005737; GO:0016021; GO:0005886 cytoplasm; integral to membrane; plasma membrane IPR000483; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR001611; IPR003591; Leucine-rich repeats and immunoglobulin-like domains protein 2 (LIG-2) LRIG2 KIAA0806 LIG2 Homo sapiens (Human) TR39234_c2_g1_i1 Q6R5N8 TLR13_MOUSE 9.00E-25 GO:0002755; GO:0005768; GO:0010008; GO:0006954; GO:0045087; GO:0016021; GO:0042803; GO:0019843; GO:0043408; GO:0002237; GO:0009615; GO:0034178; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; endosome; endosome membrane; inflammatory response; innate immune response; integral to membrane; protein homodimerization activity; rRNA binding; regulation of MAPK cascade; response to molecule of bacterial origin; response to virus; toll-like receptor 13 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR003591; IPR000157; IPR027196; Toll-like receptor 13 Tlr13 Mus musculus (Mouse) TR39234_c2_g1_i3 Q704V6 TLR6_BOVIN 1.00E-21 GO:0002755; GO:0042088; GO:0042496; GO:0006954; GO:0045087; GO:0016021; GO:0030670; GO:0005886; GO:0045410; GO:0050707; GO:0034150; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; T-helper 1 type immune response; detection of diacyl bacterial lipopeptide; inflammatory response; innate immune response; integral to membrane; phagocytic vesicle membrane; plasma membrane; positive regulation of interleukin-6 biosynthetic process; regulation of cytokine secretion; toll-like receptor 6 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR000157; IPR027187; IPR017241; Toll-like receptor 6 (CD antigen CD286) TLR6 Bos taurus (Bovine) TR39234_c2_g1_i4 Q6R5N8 TLR13_MOUSE 3.00E-25 GO:0002755; GO:0005768; GO:0010008; GO:0006954; GO:0045087; GO:0016021; GO:0042803; GO:0019843; GO:0043408; GO:0002237; GO:0009615; GO:0034178; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; endosome; endosome membrane; inflammatory response; innate immune response; integral to membrane; protein homodimerization activity; rRNA binding; regulation of MAPK cascade; response to molecule of bacterial origin; response to virus; toll-like receptor 13 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR003591; IPR000157; IPR027196; Toll-like receptor 13 Tlr13 Mus musculus (Mouse) TR39235_c5_g1_i1 Q9WTK3 GPAA1_MOUSE 1.00E-101 GO:0034235; GO:0006506; GO:0003923; GO:0042765; GO:0005887 GPI anchor binding; GPI anchor biosynthetic process; GPI-anchor transamidase activity; GPI-anchor transamidase complex; integral to plasma membrane IPR007246; IPR017063; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Glycosylphosphatidylinositol anchor attachment 1 protein (GPI anchor attachment protein 1) (GAA1 protein homolog) (mGAA1) Gpaa1 Gaa1 Mus musculus (Mouse) TR39235_c5_g1_i3 Q9WTK3 GPAA1_MOUSE 5.00E-105 GO:0034235; GO:0006506; GO:0003923; GO:0042765; GO:0005887 GPI anchor binding; GPI anchor biosynthetic process; GPI-anchor transamidase activity; GPI-anchor transamidase complex; integral to plasma membrane IPR007246; IPR017063; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Glycosylphosphatidylinositol anchor attachment 1 protein (GPI anchor attachment protein 1) (GAA1 protein homolog) (mGAA1) Gpaa1 Gaa1 Mus musculus (Mouse) TR39235_c5_g1_i7 Q9WTK3 GPAA1_MOUSE 8.00E-103 GO:0034235; GO:0006506; GO:0003923; GO:0042765; GO:0005887 GPI anchor binding; GPI anchor biosynthetic process; GPI-anchor transamidase activity; GPI-anchor transamidase complex; integral to plasma membrane IPR007246; IPR017063; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Glycosylphosphatidylinositol anchor attachment 1 protein (GPI anchor attachment protein 1) (GAA1 protein homolog) (mGAA1) Gpaa1 Gaa1 Mus musculus (Mouse) TR39236_c1_g1_i1 Q8HXY4 ODBA_MACFA 3.00E-149 GO:0003863; GO:0046872; GO:0005759 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity; metal ion binding; mitochondrial matrix IPR001017; "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha)" BCKDHA QccE-11424 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR39237_c0_g1_i1 P00504 AATC_CHICK 1.00E-164 GO:0006103; GO:0004069; GO:0047801; GO:0080130; GO:0006531; GO:0008652; GO:0005829; GO:0006094; GO:0006536; GO:0006114; GO:0030170 2-oxoglutarate metabolic process; L-aspartate:2-oxoglutarate aminotransferase activity; L-cysteine:2-oxoglutarate aminotransferase activity; L-phenylalanine:2-oxoglutarate aminotransferase activity; aspartate metabolic process; cellular amino acid biosynthetic process; cytosol; gluconeogenesis; glutamate metabolic process; glycerol biosynthetic process; pyridoxal phosphate binding IPR004839; IPR000796; IPR004838; IPR015424; IPR015421; "Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A)" GOT1 Gallus gallus (Chicken) TR39241_c0_g1_i1 P37064 ASO_CUCPM 1.00E-13 GO:0008447; GO:0005507; GO:0005576 L-ascorbate oxidase activity; copper ion binding; extracellular region IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; IPR017760; L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) Cucurbita pepo var. melopepo (Zucchini) TR39241_c0_g1_i2 Q99055 LAC4_TRAVI 1.00E-47 GO:0005507; GO:0005576; GO:0052716; GO:0046274 copper ion binding; extracellular region; hydroquinone:oxygen oxidoreductase activity; lignin catabolic process IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; Laccase-4 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 4) (Diphenol oxidase 4) (Urishiol oxidase 4) LCC4 Trametes villosa (White-rot fungus) TR39241_c0_g1_i3 Q7XE50 LAC16_ORYSJ 2.00E-12 GO:0048046; GO:0005507; GO:0052716; GO:0046274 apoplast; copper ion binding; hydroquinone:oxygen oxidoreductase activity; lignin catabolic process IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; Putative laccase-16 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 16) (Diphenol oxidase 16) (Urishiol oxidase 16) LAC16 Os10g0437400 LOC_Os10g30140 Oryza sativa subsp. japonica (Rice) TR39242_c1_g2_i4 P23469 PTPRE_HUMAN 9.00E-15 GO:0005737; GO:0016021; GO:0045111; GO:0046627; GO:0005634; GO:0005886; GO:0033003; GO:0005001; GO:0007185 cytoplasm; integral to membrane; intermediate filament cytoskeleton; negative regulation of insulin receptor signaling pathway; nucleus; plasma membrane; regulation of mast cell activation; transmembrane receptor protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase signaling pathway IPR000387; IPR016130; IPR000242; IPR016336; Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) TR39242_c1_g2_i5 P23468 PTPRD_HUMAN 8.00E-13 GO:0050839; GO:0007157; GO:0005887; GO:0030182; GO:0050775; GO:0097105; GO:0005102; GO:0005001; GO:0007185 cell adhesion molecule binding; heterophilic cell-cell adhesion; integral to plasma membrane; neuron differentiation; positive regulation of dendrite morphogenesis; presynaptic membrane assembly; receptor binding; transmembrane receptor protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase signaling pathway IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48) PTPRD Homo sapiens (Human) TR39245_c0_g1_i1 Q9UI36 DACH1_HUMAN 2.00E-57 GO:0003677; GO:0001078; GO:0001075; GO:0008283; GO:0005737; GO:0046545; GO:0030336; GO:0060244; GO:0048147; GO:0010944; GO:0005730; GO:0000166; GO:0007585; GO:0001967; GO:0005667 Q9UJ70; O75376; Q13485 DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly; cell proliferation; cytoplasm; development of primary female sexual characteristics; negative regulation of cell migration; negative regulation of cell proliferation involved in contact inhibition; negative regulation of fibroblast proliferation; negative regulation of transcription by competitive promoter binding; nucleolus; nucleotide binding; respiratory gaseous exchange; suckling behavior; transcription factor complex IPR009061; IPR003380; Dachshund homolog 1 (Dach1) DACH1 DACH Homo sapiens (Human) TR39246_c1_g1_i1 Q99042 OXDA_TRIVR 2.00E-21 GO:0003884 D-amino-acid oxidase activity IPR023209; IPR006181; IPR006076; D-amino-acid oxidase (DAAO) (DAMOX) (DAO) (EC 1.4.3.3) DAO1 Trigonopsis variabilis (Yeast) TR39246_c1_g1_i5 P18894 OXDA_MOUSE 4.00E-87 GO:0055130; GO:0003884; GO:0036088; GO:0071949; GO:0048037; GO:0005829; GO:0042416; GO:0006551; GO:0005741; GO:0005778; GO:0006562 D-alanine catabolic process; D-amino-acid oxidase activity; D-serine catabolic process; FAD binding; cofactor binding; cytosol; dopamine biosynthetic process; leucine metabolic process; mitochondrial outer membrane; peroxisomal membrane; proline catabolic process IPR023209; IPR006181; IPR006076; IPR016040; D-amino-acid oxidase (DAAO) (DAMOX) (DAO) (EC 1.4.3.3) Dao Dao1 Mus musculus (Mouse) TR39246_c1_g1_i7 A8XJ44 OXDA2_CAEBR 8.00E-63 GO:0003884; GO:0005777 D-amino-acid oxidase activity; peroxisome IPR023209; IPR006076; IPR016040; D-amino-acid oxidase 2 (DAAO 2) (DAMOX 2) (DAO 2) (EC 1.4.3.3) CBG13882 Caenorhabditis briggsae TR39247_c3_g1_i1 Q6QI06 RICTR_MOUSE 1.00E-22 GO:0031929; GO:0031932; GO:0031532; GO:0009790; GO:0032008; GO:0030838; GO:0050731; GO:0032314; GO:0030334; GO:0051896; GO:0043022 Q9JLN9 TOR signaling cascade; TORC2 complex; actin cytoskeleton reorganization; embryo development; positive regulation of TOR signaling cascade; positive regulation of actin filament polymerization; positive regulation of peptidyl-tyrosine phosphorylation; regulation of Rac GTPase activity; regulation of cell migration; regulation of protein kinase B signaling cascade; ribosome binding IPR016024; IPR028268; IPR028267; IPR028272; Rapamycin-insensitive companion of mTOR (AVO3 homolog) (mAVO3) (Protein pianissimo) Rictor Kiaa1999 Mus musculus (Mouse) TR39248_c1_g2_i1 P0C6F1 DYH2_MOUSE 0 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR026976; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 2, axonemal (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2)" Dnah2 Dnahc2 Mus musculus (Mouse) TR39248_c1_g2_i2 Q9C0G6 DYH6_HUMAN 0 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 6, axonemal (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6)" DNAH6 DNAHC6 DNHL1 HL2 KIAA1697 Homo sapiens (Human) TR39248_c2_g2_i2 Q3V0Q1 DYH12_MOUSE 1.00E-65 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018; GO:0016567 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement; protein ubiquitination IPR003593; IPR011704; IPR026983; IPR024317; IPR004273; IPR013602; IPR027417; Protein modification; protein ubiquitination. "Dynein heavy chain 12, axonemal (Axonemal beta dynein heavy chain 12) (Axonemal dynein heavy chain 12-like protein) (Axonemal dynein heavy chain 7-like protein) (Ciliary dynein heavy chain 12)" Dnah12 Dnah12l Dnah7l Dnahc12 Dnahc7l Mus musculus (Mouse) TR39248_c2_g2_i3 Q9C0G6 DYH6_HUMAN 2.00E-113 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 6, axonemal (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6)" DNAH6 DNAHC6 DNHL1 HL2 KIAA1697 Homo sapiens (Human) TR39248_c2_g3_i1 Q8IBG1 DYHC1_PLAF7 2.00E-14 GO:0005524; GO:0006200; GO:0016887; GO:0005737; GO:0030286; GO:0005874; GO:0005875; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cytoplasm; dynein complex; microtubule; microtubule associated complex; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; Dynein heavy chain-like protein MAL7P1.162 MAL7P1.162 Plasmodium falciparum (isolate 3D7) TR39248_c4_g1_i1 P45444 DYHC_EMENI 3.00E-06 GO:0005524; GO:0016887; GO:0030428; GO:0005868; GO:0031122; GO:0001411; GO:0070789; GO:0005874; GO:0008017; GO:0008569; GO:0007097; GO:0047496 ATP binding; ATPase activity; cell septum; cytoplasmic dynein complex; cytoplasmic microtubule organization; hyphal tip; metula development; microtubule; microtubule binding; minus-end-directed microtubule motor activity; nuclear migration; vesicle transport along microtubule IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain, cytoplasmic (Dynein heavy chain, cytosolic) (DYHC)" nudA AN0118 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR39249_c5_g2_i1 Q92847 GHSR_HUMAN 4.00E-11 GO:0008154; GO:0008343; GO:0009986; GO:0032869; GO:0046697; GO:0001616; GO:0030252; GO:0016520; GO:0009755; GO:0016021; GO:0045121; GO:0050728; GO:0046676; GO:0032691; GO:0045409; GO:0042536; GO:0043005; GO:0017046; GO:0005886; GO:0032100; GO:0045923; GO:0043568; GO:0040018; GO:0043134; GO:0051963; GO:0032094 actin polymerization or depolymerization; adult feeding behavior; cell surface; cellular response to insulin stimulus; decidualization; growth hormone secretagogue receptor activity; growth hormone secretion; growth hormone-releasing hormone receptor activity; hormone-mediated signaling pathway; integral to membrane; membrane raft; negative regulation of inflammatory response; negative regulation of insulin secretion; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 biosynthetic process; negative regulation of tumor necrosis factor biosynthetic process; neuron projection; peptide hormone binding; plasma membrane; positive regulation of appetite; positive regulation of fatty acid metabolic process; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; regulation of hindgut contraction; regulation of synapse assembly; response to food IPR003905; IPR000276; IPR017452; Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) GHSR Homo sapiens (Human) TR39249_c5_g2_i2 A5A4L1 GHSR_MUSPF 4.00E-10 GO:0008154; GO:0008343; GO:0009986; GO:0032869; GO:0046697; GO:0001616; GO:0030252; GO:0016520; GO:0009755; GO:0016021; GO:0045121; GO:0050728; GO:0032691; GO:0045409; GO:0042536; GO:0043005; GO:0005886; GO:0032100; GO:0043568; GO:0040018; GO:0051963; GO:0032094 actin polymerization or depolymerization; adult feeding behavior; cell surface; cellular response to insulin stimulus; decidualization; growth hormone secretagogue receptor activity; growth hormone secretion; growth hormone-releasing hormone receptor activity; hormone-mediated signaling pathway; integral to membrane; membrane raft; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 biosynthetic process; negative regulation of tumor necrosis factor biosynthetic process; neuron projection; plasma membrane; positive regulation of appetite; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; regulation of synapse assembly; response to food IPR003905; IPR000276; IPR017452; Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) GHSR Mustela putorius furo (European domestic ferret) (Mustela furo) TR39249_c5_g2_i3 Q6TLI9 DRD2_MUSPF 4.00E-06 GO:0021984; GO:0007195; GO:0004935; GO:0071875; GO:0007628; GO:0050482; GO:0030424; GO:0007409; GO:0048148; GO:0048149; GO:0048755; GO:0021853; GO:0032922; GO:0030425; GO:0035240; GO:0042417; GO:0001591; GO:0051482; GO:0007631; GO:0007625; GO:0005887; GO:0007243; GO:0045776; GO:0030336; GO:0008285; GO:0060160; GO:0051898; GO:0050709; GO:0051967; GO:0001976; GO:0007270; GO:0030432; GO:0060158; GO:0043473; GO:0051586; GO:0060124; GO:0040018; GO:0002052; GO:0035815; GO:0035810; GO:0060134; GO:0008104; GO:0030814; GO:0014059; GO:0002027; GO:0048169; GO:0043266; GO:0002028; GO:0032228; GO:0001975; GO:0042493; GO:0034776; GO:0043278; GO:0007608; GO:0001659; GO:0008542 "adenohypophysis development; adenylate cyclase-inhibiting dopamine receptor signaling pathway; adrenergic receptor activity; adrenergic receptor signaling pathway; adult walking behavior; arachidonic acid secretion; axon; axonogenesis; behavioral response to cocaine; behavioral response to ethanol; branching morphogenesis of a nerve; cerebral cortex GABAergic interneuron migration; circadian regulation of gene expression; dendrite; dopamine binding; dopamine metabolic process; dopamine neurotransmitter receptor activity, coupled via Gi/Go; elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; feeding behavior; grooming behavior; integral to plasma membrane; intracellular protein kinase cascade; negative regulation of blood pressure; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of dopamine receptor signaling pathway; negative regulation of protein kinase B signaling cascade; negative regulation of protein secretion; negative regulation of synaptic transmission, glutamatergic; neurological system process involved in regulation of systemic arterial blood pressure; neuron-neuron synaptic transmission; peristalsis; phospholipase C-activating dopamine receptor signaling pathway; pigmentation; positive regulation of dopamine uptake involved in synaptic transmission; positive regulation of growth hormone secretion; positive regulation of multicellular organism growth; positive regulation of neuroblast proliferation; positive regulation of renal sodium excretion; positive regulation of urine volume; prepulse inhibition; protein localization; regulation of cAMP metabolic process; regulation of dopamine secretion; regulation of heart rate; regulation of long-term neuronal synaptic plasticity; regulation of potassium ion transport; regulation of sodium ion transport; regulation of synaptic transmission, GABAergic; response to amphetamine; response to drug; response to histamine; response to morphine; sensory perception of smell; temperature homeostasis; visual learning" IPR002233; IPR001922; IPR000929; IPR000276; IPR017452; D(2) dopamine receptor (Dopamine D2 receptor) DRD2 Mustela putorius furo (European domestic ferret) (Mustela furo) TR39252_c0_g1_i1 Q8K450 SPG16_MOUSE 0 GO:0042384; GO:0035085; GO:0005874; GO:0005634; GO:0007283 cilium assembly; cilium axoneme; microtubule; nucleus; spermatogenesis IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Sperm-associated antigen 16 protein (Pf20 protein homolog) Spag16 Pf20 Mus musculus (Mouse) TR39253_c0_g1_i3 Q60439 CDN1B_CRIGR 1.00E-10 GO:0007050; GO:0004861; GO:0005768; GO:0006469; GO:0005634 cell cycle arrest; cyclin-dependent protein serine/threonine kinase inhibitor activity; endosome; negative regulation of protein kinase activity; nucleus IPR003175; Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) CDKN1B KIP1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR39253_c0_g1_i5 Q60439 CDN1B_CRIGR 3.00E-12 GO:0007050; GO:0004861; GO:0005768; GO:0006469; GO:0005634 cell cycle arrest; cyclin-dependent protein serine/threonine kinase inhibitor activity; endosome; negative regulation of protein kinase activity; nucleus IPR003175; Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) CDKN1B KIP1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR39254_c0_g1_i1 Q96KA5 CLP1L_HUMAN 2.00E-105 GO:0006915; GO:0016021 apoptotic process; integral to membrane IPR008429; Cleft lip and palate transmembrane protein 1-like protein (CLPTM1-like protein) (Cisplatin resistance-related protein 9) (CRR9p) CLPTM1L CRR9 Homo sapiens (Human) TR39254_c0_g1_i2 Q2NL17 CLPT1_BOVIN 0 GO:0030154; GO:0016021; GO:0007275 cell differentiation; integral to membrane; multicellular organismal development IPR008429; Cleft lip and palate transmembrane protein 1 homolog CLPTM1 Bos taurus (Bovine) TR39256_c1_g3_i3 Q4R4I9 PRAF2_MACFA 2.00E-53 GO:0010008; GO:0016021; GO:0015031 endosome membrane; integral to membrane; protein transport IPR004895; PRA1 family protein 2 PRAF2 QtrA-11986 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR39256_c1_g3_i5 Q4R4I9 PRAF2_MACFA 1.00E-54 GO:0010008; GO:0016021; GO:0015031 endosome membrane; integral to membrane; protein transport IPR004895; PRA1 family protein 2 PRAF2 QtrA-11986 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR39257_c2_g3_i4 Q9H3S7 PTN23_HUMAN 1.00E-63 GO:0005929; GO:0060271; GO:0016023; GO:0005769; GO:0005932; GO:0005634; GO:0035335; GO:0015031; GO:0004725; GO:0043162 Q9H444; O75791; O89100; P62993; O75340; Q05397; Q99962; Q99816 cilium; cilium morphogenesis; cytoplasmic membrane-bounded vesicle; early endosome; microtubule basal body; nucleus; peptidyl-tyrosine dephosphorylation; protein transport; protein tyrosine phosphatase activity; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IPR025304; IPR004328; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) PTPN23 KIAA1471 Homo sapiens (Human) TR39258_c0_g4_i1 Q969T9 WBP2_HUMAN 5.00E-37 Q9GZV5 IPR004182; IPR018826; WW domain-binding protein 2 (WBP-2) WBP2 Homo sapiens (Human) TR39260_c0_g1_i1 O94903 PROSC_HUMAN 7.00E-80 GO:0005737; GO:0005739; GO:0030170 cytoplasm; mitochondrion; pyridoxal phosphate binding IPR001608; IPR011078; Proline synthase co-transcribed bacterial homolog protein PROSC Homo sapiens (Human) TR39263_c1_g3_i3 Q02977 YRK_CHICK 2.00E-08 GO:0005524; GO:0004715; GO:0018108 ATP binding; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2) (Yes-related kinase) (p60-Yrk) YRK Gallus gallus (Chicken) TR39263_c1_g3_i6 P09324 YES_CHICK 2.00E-06 GO:0005524; GO:0005794; GO:0005829; GO:0015758; GO:0005815; GO:0004715; GO:0018108; GO:0005886 ATP binding; Golgi apparatus; cytosol; glucose transport; microtubule organizing center; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation; plasma membrane IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) YES1 YES Gallus gallus (Chicken) TR39263_c1_g3_i7 Q5NVP3 F107A_PONAB 1.00E-07 GO:0005634; GO:0001558 nucleus; regulation of cell growth IPR009533; Protein FAM107A FAM107A DRR1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39264_c1_g2_i1 Q9CWP8 DPOD4_MOUSE 5.00E-20 GO:0006260; GO:0003887; GO:0005634; GO:0001938 DNA replication; DNA-directed DNA polymerase activity; nucleus; positive regulation of endothelial cell proliferation IPR007218; DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12) Pold4 Mus musculus (Mouse) TR39264_c1_g2_i2 O59835 DPOD4_SCHPO 5.00E-10 GO:0006271; GO:0000731; GO:0003887; GO:0005829; GO:0043625 DNA strand elongation involved in DNA replication; DNA synthesis involved in DNA repair; DNA-directed DNA polymerase activity; cytosol; delta DNA polymerase complex IPR007218; DNA polymerase delta subunit 4 cdm1 SPBC12D12.02c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR39264_c2_g1_i1 A6H7G2 DBNL_BOVIN 6.00E-61 GO:0000139; GO:0016601; GO:0051015; GO:0005938; GO:0030054; GO:0030665; GO:0005829; GO:0006897; GO:0030027; GO:0048812; GO:0005886; GO:0002102; GO:0071800; GO:0001726; GO:0045202; GO:0007416 Golgi membrane; Rac protein signal transduction; actin filament binding; cell cortex; cell junction; clathrin-coated vesicle membrane; cytosol; endocytosis; lamellipodium; neuron projection morphogenesis; plasma membrane; podosome; podosome assembly; ruffle; synapse; synapse assembly IPR002108; IPR001452; Drebrin-like protein DBNL Bos taurus (Bovine) TR39264_c2_g1_i2 Q6GM14 DBNLB_XENLA 7.00E-57 GO:0000139; GO:0005938; GO:0030054; GO:0030665; GO:0005829; GO:0030027; GO:0005886; GO:0002102; GO:0001726; GO:0045202; GO:0006810 Golgi membrane; cell cortex; cell junction; clathrin-coated vesicle membrane; cytosol; lamellipodium; plasma membrane; podosome; ruffle; synapse; transport IPR002108; IPR001452; Drebrin-like protein B dbnl-b Xenopus laevis (African clawed frog) TR39264_c2_g2_i1 Q01406 SRC8_CHICK 6.00E-14 GO:0005856; GO:0043197; GO:0005783; GO:0030027; GO:0005886; GO:0001726 P39054; Q8AYS8 cytoskeleton; dendritic spine; endoplasmic reticulum; lamellipodium; plasma membrane; ruffle IPR015503; IPR003134; IPR000108; IPR001452; Src substrate protein p85 (Cortactin) (p80) CTTN1 EMS1 P85.25 Gallus gallus (Chicken) TR39266_c1_g1_i1 Q8TCA0 LRC20_HUMAN 2.00E-24 IPR001611; Leucine-rich repeat-containing protein 20 LRRC20 UNQ2429/PRO4989 Homo sapiens (Human) TR39267_c0_g4_i1 P11442 CLH_RAT 0 GO:0007030; GO:0030315; GO:0030506; GO:0030118; GO:0030132; GO:0030130; GO:0030669; GO:0031072; GO:0006886; GO:0042470; GO:0007067; GO:0042277; GO:0006898; GO:0005819; GO:0005198 Q01968 Golgi organization; T-tubule; ankyrin binding; clathrin coat; clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; clathrin-coated endocytic vesicle membrane; heat shock protein binding; intracellular protein transport; melanosome; mitosis; peptide binding; receptor-mediated endocytosis; spindle; structural molecule activity IPR016024; IPR000547; IPR016025; IPR015348; IPR001473; IPR022365; IPR016341; IPR011990; Clathrin heavy chain 1 Cltc Rattus norvegicus (Rat) TR39268_c2_g1_i2 O14037 YEY4_SCHPO 4.00E-23 GO:0005829; GO:0005634 cytosol; nucleus IPR018794; UPF0538 protein C2C4.04c SPAC2C4.04c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR39268_c2_g1_i3 Q66IB8 CB076_DANRE 1.00E-41 IPR018794; UPF0538 protein C2orf76 homolog zgc:101851 Danio rerio (Zebrafish) (Brachydanio rerio) TR39268_c4_g1_i1 P22003 BMP5_HUMAN 2.00E-80 GO:0051216; GO:0005125; GO:0005615; GO:0040007; GO:0030539; GO:0031988; GO:0032348; GO:0008285; GO:2000065; GO:0010719; GO:1902042; GO:0043569; GO:0071676; GO:0001503; GO:0007389; GO:2000105; GO:1900006; GO:0050679; GO:0010862; GO:0045944; GO:0001501; GO:0003323 cartilage development; cytokine activity; extracellular space; growth; male genitalia development; membrane-bounded vesicle; negative regulation of aldosterone biosynthetic process; negative regulation of cell proliferation; negative regulation of cortisol biosynthetic process; negative regulation of epithelial to mesenchymal transition; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of mononuclear cell migration; ossification; pattern specification process; positive regulation of DNA-dependent DNA replication; positive regulation of dendrite development; positive regulation of epithelial cell proliferation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; skeletal system development; type B pancreatic cell development IPR001839; IPR001111; IPR015615; IPR017948; Bone morphogenetic protein 5 (BMP-5) BMP5 Homo sapiens (Human) TR39268_c4_g1_i2 Q24735 60A_DROVI 6.00E-78 GO:0005615; GO:0040007 extracellular space; growth IPR001839; IPR001111; IPR015615; IPR017948; Protein 60A (Protein glass bottom boat) gbb 60A TGFb-60A Drosophila virilis (Fruit fly) TR39268_c4_g1_i3 O93449 TGFB1_ONCMY 4.00E-08 GO:0016049; GO:0005615; GO:0051781 cell growth; extracellular space; positive regulation of cell division IPR001839; IPR001111; IPR016319; IPR015615; IPR003939; IPR017948; Transforming growth factor beta-1 (TGF-beta-1) tgfb1 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR39268_c4_g1_i4 P23359 BMP7_MOUSE 7.00E-86 GO:0070700; GO:0030509; GO:0060395; GO:0007411; GO:0060445; GO:0048754; GO:0051216; GO:0005125; GO:0048596; GO:0030326; GO:0009880; GO:0060272; GO:0030855; GO:0005615; GO:0040007; GO:0048762; GO:0001707; GO:0001823; GO:0072136; GO:0072133; GO:0070487; GO:0043407; GO:0045746; GO:0072125; GO:0072040; GO:0045839; GO:0050768; GO:0045665; GO:0060686; GO:0045892; GO:0072134; GO:0042475; GO:0001503; GO:0043065; GO:0030501; GO:1900006; GO:0034116; GO:1900106; GO:0045666; GO:0045669; GO:0010862; GO:0010800; GO:0045944; GO:0034504; GO:0060687; GO:0043401; GO:0001657 "BMP receptor binding; BMP signaling pathway; SMAD protein signal transduction; axon guidance; branching involved in salivary gland morphogenesis; branching morphogenesis of an epithelial tube; cartilage development; cytokine activity; embryonic camera-type eye morphogenesis; embryonic limb morphogenesis; embryonic pattern specification; embryonic skeletal joint morphogenesis; epithelial cell differentiation; extracellular space; growth; mesenchymal cell differentiation; mesoderm formation; mesonephros development; metanephric mesenchymal cell proliferation involved in metanephros development; metanephric mesenchyme morphogenesis; monocyte aggregation; negative regulation of MAP kinase activity; negative regulation of Notch signaling pathway; negative regulation of glomerular mesangial cell proliferation; negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis; negative regulation of mitosis; negative regulation of neurogenesis; negative regulation of neuron differentiation; negative regulation of prostatic bud formation; negative regulation of transcription, DNA-dependent; nephrogenic mesenchyme morphogenesis; odontogenesis of dentin-containing tooth; ossification; positive regulation of apoptotic process; positive regulation of bone mineralization; positive regulation of dendrite development; positive regulation of heterotypic cell-cell adhesion; positive regulation of hyaluranon cable assembly; positive regulation of neuron differentiation; positive regulation of osteoblast differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein localization to nucleus; regulation of branching involved in prostate gland morphogenesis; steroid hormone mediated signaling pathway; ureteric bud development" IPR001839; IPR001111; IPR015615; IPR017948; Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) Bmp7 Bmp-7 Op1 Mus musculus (Mouse) TR39268_c4_g1_i6 P23359 BMP7_MOUSE 1.00E-83 GO:0070700; GO:0030509; GO:0060395; GO:0007411; GO:0060445; GO:0048754; GO:0051216; GO:0005125; GO:0048596; GO:0030326; GO:0009880; GO:0060272; GO:0030855; GO:0005615; GO:0040007; GO:0048762; GO:0001707; GO:0001823; GO:0072136; GO:0072133; GO:0070487; GO:0043407; GO:0045746; GO:0072125; GO:0072040; GO:0045839; GO:0050768; GO:0045665; GO:0060686; GO:0045892; GO:0072134; GO:0042475; GO:0001503; GO:0043065; GO:0030501; GO:1900006; GO:0034116; GO:1900106; GO:0045666; GO:0045669; GO:0010862; GO:0010800; GO:0045944; GO:0034504; GO:0060687; GO:0043401; GO:0001657 "BMP receptor binding; BMP signaling pathway; SMAD protein signal transduction; axon guidance; branching involved in salivary gland morphogenesis; branching morphogenesis of an epithelial tube; cartilage development; cytokine activity; embryonic camera-type eye morphogenesis; embryonic limb morphogenesis; embryonic pattern specification; embryonic skeletal joint morphogenesis; epithelial cell differentiation; extracellular space; growth; mesenchymal cell differentiation; mesoderm formation; mesonephros development; metanephric mesenchymal cell proliferation involved in metanephros development; metanephric mesenchyme morphogenesis; monocyte aggregation; negative regulation of MAP kinase activity; negative regulation of Notch signaling pathway; negative regulation of glomerular mesangial cell proliferation; negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis; negative regulation of mitosis; negative regulation of neurogenesis; negative regulation of neuron differentiation; negative regulation of prostatic bud formation; negative regulation of transcription, DNA-dependent; nephrogenic mesenchyme morphogenesis; odontogenesis of dentin-containing tooth; ossification; positive regulation of apoptotic process; positive regulation of bone mineralization; positive regulation of dendrite development; positive regulation of heterotypic cell-cell adhesion; positive regulation of hyaluranon cable assembly; positive regulation of neuron differentiation; positive regulation of osteoblast differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein localization to nucleus; regulation of branching involved in prostate gland morphogenesis; steroid hormone mediated signaling pathway; ureteric bud development" IPR001839; IPR001111; IPR015615; IPR017948; Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) Bmp7 Bmp-7 Op1 Mus musculus (Mouse) TR39268_c4_g1_i8 P25703 BMP2A_XENLA 4.00E-35 GO:0051216; GO:0030154; GO:0005615; GO:0040007; GO:0001503 cartilage development; cell differentiation; extracellular space; growth; ossification IPR002405; IPR001839; IPR001111; IPR015615; IPR017948; Bone morphogenetic protein 2-A (BMP-2-I) bmp2-a Xenopus laevis (African clawed frog) TR39269_c1_g1_i1 Q7Z402 TMC7_HUMAN 1.00E-22 GO:0016021; GO:0006811 integral to membrane; ion transport IPR012496; Transmembrane channel-like protein 7 TMC7 Homo sapiens (Human) TR39269_c2_g1_i1 Q8C428 TMC7_MOUSE 1.00E-50 GO:0016021; GO:0006811 integral to membrane; ion transport IPR012496; Transmembrane channel-like protein 7 Tmc7 Mus musculus (Mouse) TR39269_c2_g1_i4 Q7Z5M5 TMC3_HUMAN 3.00E-31 GO:0016021; GO:0006811 integral to membrane; ion transport IPR012496; Transmembrane channel-like protein 3 TMC3 Homo sapiens (Human) TR39269_c2_g1_i6 Q5M7W4 TMC5_RAT 5.00E-48 GO:0016021; GO:0006811 integral to membrane; ion transport IPR012496; Transmembrane channel-like protein 5 Tmc5 Rattus norvegicus (Rat) TR39270_c5_g1_i1 O60016 CLR4_SCHPO 2.00E-21 GO:0043494; GO:0051315; GO:0030702; GO:0000183; GO:0030466; GO:0006348; GO:0031048; GO:0005737; GO:0007535; GO:0030989; GO:0031507; GO:0046974; GO:0031934; GO:0045141; GO:0044732; GO:0000122; GO:0031618; GO:0005724; GO:0032015; GO:0090065; GO:0008270 O14122; Q10426; O94276 CLRC ubiquitin ligase complex; attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation; chromatin silencing at centromere; chromatin silencing at rDNA; chromatin silencing at silent mating-type cassette; chromatin silencing at telomere; chromatin silencing by small RNA; cytoplasm; donor selection; dynein-driven meiotic oscillatory nuclear movement; heterochromatin assembly; histone methyltransferase activity (H3-K9 specific); mating-type region heterochromatin; meiotic telomere clustering; mitotic spindle pole body; negative regulation of transcription from RNA polymerase II promoter; nuclear centromeric heterochromatin; nuclear telomeric heterochromatin; regulation of Ran protein signal transduction; regulation of production of siRNA involved in RNA interference; zinc ion binding IPR023780; IPR000953; IPR016197; IPR023779; IPR003616; IPR007728; IPR003606; IPR001214; "Histone-lysine N-methyltransferase, H3 lysine-9 specific (EC 2.1.1.43) (Cryptic loci regulator 4) (Histone H3-K9 methyltransferase) (H3-K9-HMTase) (Lysine N-methyltransferase 1)" clr4 kmt1 SPBC428.08c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR39270_c5_g1_i2 Q99MY8 ASH1L_MOUSE 0 GO:0003677; GO:0005694; GO:0034968; GO:0018024; GO:0005634; GO:0006355; GO:0005923; GO:0006351; GO:0008270 "DNA binding; chromosome; histone lysine methylation; histone-lysine N-methyltransferase activity; nucleus; regulation of transcription, DNA-dependent; tight junction; transcription, DNA-dependent; zinc ion binding" IPR017956; IPR006560; IPR001025; IPR001487; IPR003616; IPR001214; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.43) (ASH1-like protein) (Absent small and homeotic disks protein 1 homolog) Ash1l Mus musculus (Mouse) TR39271_c0_g1_i3 Q7SIG4 DFPA_LOLVU 2.00E-130 GO:0005509; GO:0047862 calcium ion binding; diisopropyl-fluorophosphatase activity IPR011042; IPR013658; Diisopropyl-fluorophosphatase (DFPase) (EC 3.1.8.2) Loligo vulgaris (Common European squid) TR39272_c0_g1_i1 Q9MZD1 S17A5_SHEEP 5.00E-94 GO:0016021; GO:0005765; GO:0015293 integral to membrane; lysosomal membrane; symporter activity IPR011701; IPR020846; IPR016196; Sialin (Membrane glycoprotein SP55) (Sodium/sialic acid cotransporter) (Solute carrier family 17 member 5) SLC17A5 Ovis aries (Sheep) TR39272_c0_g1_i2 O61369 PICO_DROAN 7.00E-83 GO:0005315; GO:0016021; GO:0015114; GO:0006817; GO:0006814; GO:0015293 inorganic phosphate transmembrane transporter activity; integral to membrane; phosphate ion transmembrane transporter activity; phosphate ion transport; sodium ion transport; symporter activity IPR011701; IPR020846; IPR016196; IPR004745; Putative inorganic phosphate cotransporter Picot Drosophila ananassae (Fruit fly) TR39272_c0_g1_i4 Q9NRA2 S17A5_HUMAN 3.00E-94 GO:0006865; GO:0030054; GO:0005887; GO:0005765; GO:0015136; GO:0015739; GO:0005351; GO:0030672 amino acid transport; cell junction; integral to plasma membrane; lysosomal membrane; sialic acid transmembrane transporter activity; sialic acid transport; sugar:hydrogen symporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) TR39272_c0_g1_i6 P42205 GUDP_PSEPU 3.00E-10 GO:0016021; GO:0005886; GO:0055085; GO:0005215 integral to membrane; plasma membrane; transmembrane transport; transporter activity IPR004744; IPR011701; IPR020846; IPR016196; Probable glucarate transporter (D-glucarate permease) gudP Pseudomonas putida (Arthrobacter siderocapsulatus) TR39274_c1_g2_i3 P08548 LIN1_NYCCO 4.00E-07 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR39274_c1_g2_i4 P08548 LIN1_NYCCO 6.00E-06 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR39275_c1_g1_i5 Q0IHH1 NAA30_XENLA 4.00E-79 GO:0008080 N-acetyltransferase activity IPR016181; IPR000182; N-alpha-acetyltransferase 30 (EC 2.3.1.-) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit) naa30 mak3 nat12 Xenopus laevis (African clawed frog) TR39276_c0_g1_i1 P46551 CDK12_CAEEL 1.00E-11 GO:0005524; GO:0008353; GO:0004693; GO:0005634 ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; cyclin-dependent protein serine/threonine kinase activity; nucleus IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division cycle 2-related protein kinase 7) (Cell division protein kinase 12) cdtl-7 B0285.1/B0285.2 Caenorhabditis elegans TR39276_c0_g2_i1 Q0GGW5 STK11_CHICK 2.00E-72 GO:0005524; GO:0007050; GO:0005829; GO:0030010; GO:0042593; GO:0072332; GO:0000287; GO:0016020; GO:0005739; GO:0030308; GO:0005634; GO:0002039; GO:0046777; GO:0030295; GO:0004674; GO:0006974; GO:0010212; GO:0001944 ATP binding; cell cycle arrest; cytosol; establishment of cell polarity; glucose homeostasis; intrinsic apoptotic signaling pathway by p53 class mediator; magnesium ion binding; membrane; mitochondrion; negative regulation of cell growth; nucleus; p53 binding; protein autophosphorylation; protein kinase activator activity; protein serine/threonine kinase activity; response to DNA damage stimulus; response to ionizing radiation; vasculature development IPR020636; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1 homolog) (LKB1) STK11 Gallus gallus (Chicken) TR39276_c0_g2_i2 Q54W86 MYLKF_DICDI 4.00E-09 GO:0005524; GO:0004687 ATP binding; myosin light chain kinase activity IPR020636; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Probable myosin light chain kinase DDB_G0279831 (EC 2.7.11.18) DDB_G0279831 Dictyostelium discoideum (Slime mold) TR39277_c3_g4_i1 Q96AD5 PLPL2_HUMAN 6.00E-90 GO:0036155; GO:0005829; GO:0005789; GO:0046474; GO:0016021; GO:0005811; GO:0010891; GO:0005886; GO:0010898; GO:0044281; GO:0019433; GO:0004806 acylglycerol acyl-chain remodeling; cytosol; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process; integral to membrane; lipid particle; negative regulation of sequestering of triglyceride; plasma membrane; positive regulation of triglyceride catabolic process; small molecule metabolic process; triglyceride catabolic process; triglyceride lipase activity IPR016035; IPR002641; Glycerolipid metabolism; triacylglycerol degradation. Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Calcium-independent phospholipase A2) (Desnutrin) (IPLA2-zeta) (Pigment epithelium-derived factor) (TTS2.2) (Transport-secretion protein 2) (TTS2) PNPLA2 ATGL FP17548 Homo sapiens (Human) TR39278_c0_g1_i1 Q6ZP82 CC141_HUMAN 9.00E-25 Q9NRI5 IPR007110; IPR013783; Coiled-coil domain-containing protein 141 CCDC141 Homo sapiens (Human) TR39278_c0_g4_i1 Q8WZ42 TITIN_HUMAN 3.00E-07 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR39280_c1_g2_i1 Q9Y473 ZN175_HUMAN 3.00E-39 GO:0003677; GO:0005737; GO:0051607; GO:0045111; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; cytoplasm; defense response to virus; intermediate filament cytoskeleton; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 175 (Zinc finger protein OTK18) ZNF175 Homo sapiens (Human) TR39280_c1_g2_i2 Q14591 ZN271_HUMAN 3.00E-44 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 271 (CT-ZFP48) (Epstein-Barr virus-induced zinc finger protein) (EBV-induced zinc finger protein) (ZNF-EB) (Zinc finger protein HZF7) (Zinc finger protein ZNFphex133) (Zinc finger protein dp) (ZNF-dp) ZNF271 ZNFEB Homo sapiens (Human) TR39280_c1_g2_i3 Q80V23 ZNF32_MOUSE 3.00E-45 GO:0046872; GO:0003676; GO:0005634 metal ion binding; nucleic acid binding; nucleus IPR007087; IPR015880; IPR013087; Zinc finger protein 32 (Zinc finger protein 637) Znf32 Zfp637 Mus musculus (Mouse) TR39281_c0_g1_i1 Q9VW71 FAT2_DROME 2.00E-91 GO:0009925; GO:0005509; GO:0016339; GO:0050839; GO:0050829; GO:0042247; GO:0030950; GO:0005925; GO:0007440; GO:0007295; GO:0007442; GO:0007156; GO:0005887; GO:0045571; GO:0007424; GO:0045089; GO:0004872; GO:0007431 basal plasma membrane; calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; defense response to Gram-negative bacterium; establishment of planar polarity of follicular epithelium; establishment or maintenance of actin cytoskeleton polarity; focal adhesion; foregut morphogenesis; growth of a germarium-derived egg chamber; hindgut morphogenesis; homophilic cell adhesion; integral to plasma membrane; negative regulation of imaginal disc growth; open tracheal system development; positive regulation of innate immune response; receptor activity; salivary gland development IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Fat-like cadherin-related tumor suppressor homolog (Protein kugelei) kug fat2 CG7749 Drosophila melanogaster (Fruit fly) TR39281_c0_g1_i2 Q14517 FAT1_HUMAN 4.00E-65 GO:0007015; GO:0009653; GO:0005509; GO:0016477; GO:0016337; GO:0005911; GO:0007267; GO:0007163; GO:0030175; GO:0007156; GO:0005887; GO:0030027; GO:0005634; GO:0048471 Q8N8S7; Q9NSC5; Q99JP6 actin filament organization; anatomical structure morphogenesis; calcium ion binding; cell migration; cell-cell adhesion; cell-cell junction; cell-cell signaling; establishment or maintenance of cell polarity; filopodium; homophilic cell adhesion; integral to plasma membrane; lamellipodium; nucleus; perinuclear region of cytoplasm IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) TR39282_c1_g1_i1 Q14683 SMC1A_HUMAN 0 GO:0005524; GO:0006310; GO:0006281; GO:0051301; GO:0003682; GO:0030261; GO:0008280; GO:0000777; GO:0000794; GO:0005829; GO:0000776; GO:0000398; GO:0007126; GO:0030893; GO:0003777; GO:0007093; GO:0007064; GO:0007052; GO:0032876; GO:0005654; GO:0009314; GO:0042770; GO:0019827 Q99IB8; P33993 "ATP binding; DNA recombination; DNA repair; cell division; chromatin binding; chromosome condensation; cohesin core heterodimer; condensed chromosome kinetochore; condensed nuclear chromosome; cytosol; kinetochore; mRNA splicing, via spliceosome; meiosis; meiotic cohesin complex; microtubule motor activity; mitotic cell cycle checkpoint; mitotic sister chromatid cohesion; mitotic spindle organization; negative regulation of DNA endoreduplication; nucleoplasm; response to radiation; signal transduction in response to DNA damage; stem cell maintenance" IPR027417; IPR003395; IPR024704; IPR010935; Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) SMC1A DXS423E KIAA0178 SB1.8 SMC1 SMC1L1 Homo sapiens (Human) TR39282_c1_g2_i1 Q12267 SMC4_YEAST 3.00E-29 GO:0005524; GO:0006200; GO:0006310; GO:0006281; GO:0051301; GO:0003682; GO:0005737; GO:0010032; GO:0051307; GO:0000799; GO:0070550; GO:0007062; GO:0007130; GO:0070058 Q06680 ATP binding; ATP catabolic process; DNA recombination; DNA repair; cell division; chromatin binding; cytoplasm; meiotic chromosome condensation; meiotic chromosome separation; nuclear condensin complex; rDNA condensation; sister chromatid cohesion; synaptonemal complex assembly; tRNA gene clustering IPR027417; IPR003395; IPR024704; IPR010935; Structural maintenance of chromosomes protein 4 SMC4 YLR086W L9449.5 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39283_c3_g1_i1 P11928 OAS1A_MOUSE 2.00E-23 GO:0001730; GO:0005524; GO:0051607; GO:0003725; GO:0005783; GO:0045087; GO:0046872; GO:0005739; GO:0005634; GO:0006164; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; defense response to virus; double-stranded RNA binding; endoplasmic reticulum; innate immune response; metal ion binding; mitochondrion; nucleus; purine nucleotide biosynthetic process; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 1A ((2-5')oligo(A) synthase 1A) (2-5A synthase 1A) (EC 2.7.7.84) (p42 OAS) Oas1a Oias1 Mus musculus (Mouse) TR39283_c3_g1_i2 Q8VI93 OAS3_MOUSE 4.00E-21 GO:0001730; GO:0005524; GO:0005737; GO:0051607; GO:0003725; GO:0045087; GO:0046872; GO:0045071; GO:0005634; GO:0060700; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; cytoplasm; defense response to virus; double-stranded RNA binding; innate immune response; metal ion binding; negative regulation of viral genome replication; nucleus; regulation of ribonuclease activity; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; "2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (2',5'-oligoadenylate synthetase-like 10)" Oas3 oasl10 Mus musculus (Mouse) TR39283_c3_g1_i5 Q9Y6K5 OAS3_HUMAN 2.00E-23 GO:0001730; GO:0005524; GO:0005829; GO:0051607; GO:0003725; GO:0060333; GO:0043231; GO:0046872; GO:0045071; GO:0006139; GO:0005634; GO:0060700; GO:0060337 Q7L2E3; P56537; Q8IY81; Q12894; Q7Z434 2'-5'-oligoadenylate synthetase activity; ATP binding; cytosol; defense response to virus; double-stranded RNA binding; interferon-gamma-mediated signaling pathway; intracellular membrane-bounded organelle; metal ion binding; negative regulation of viral genome replication; nucleobase-containing compound metabolic process; nucleus; regulation of ribonuclease activity; type I interferon-mediated signaling pathway IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (p100 OAS) (p100OAS) OAS3 P/OKcl.4 Homo sapiens (Human) TR39288_c1_g2_i1 Q96MM3 ZFP42_HUMAN 4.00E-72 GO:0003677; GO:0005737; GO:0008585; GO:0008584; GO:0007126; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; cytoplasm; female gonad development; male gonad development; meiosis; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 42 homolog (Zfp-42) (Reduced expression protein 1) (REX-1) (hREX-1) (Zinc finger protein 754) ZFP42 REX1 ZNF754 Homo sapiens (Human) TR39288_c1_g2_i2 P25490 TYY1_HUMAN 5.00E-111 GO:0031011; GO:0003723; GO:0001078; GO:0030154; GO:0034644; GO:0000724; GO:0000400; GO:0016363; GO:0005886; GO:0010225; GO:0007283; GO:0003713; GO:0003714; GO:0044212; GO:0008270 P03259; O96019; P49407; Q8JSK4; Q9ULG1; P78527; Q9Y265; Q9Y230; Q8CCI5 Ino80 complex; RNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; cell differentiation; cellular response to UV; double-strand break repair via homologous recombination; four-way junction DNA binding; nuclear matrix; plasma membrane; response to UV-C; spermatogenesis; transcription coactivator activity; transcription corepressor activity; transcription regulatory region DNA binding; zinc ion binding IPR017114; IPR007087; IPR015880; IPR013087; Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1) YY1 INO80S Homo sapiens (Human) TR39288_c1_g2_i3 Q8ST83 PHO_DROME 3.00E-75 GO:0006310; GO:0006281; GO:0006265; GO:0031011; GO:0000980; GO:0031490; GO:0006342; GO:0048096; GO:0046872; GO:0007275; GO:0005704; GO:0005703; GO:0006351 Q9VDY1; Q9VK33 "DNA recombination; DNA repair; DNA topological change; Ino80 complex; RNA polymerase II distal enhancer sequence-specific DNA binding; chromatin DNA binding; chromatin silencing; chromatin-mediated maintenance of transcription; metal ion binding; multicellular organismal development; polytene chromosome band; polytene chromosome puff; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Polycomb protein PHO (Protein pleiohomeotic) (Transcription factor YY1 homolog) pho CG17743 Drosophila melanogaster (Fruit fly) TR39289_c0_g3_i3 P97801 SMN_MOUSE 6.00E-21 GO:0003723; GO:0008380; GO:0007409; GO:0005737; GO:0006397; GO:0007019; GO:0005634; GO:0005681 RNA binding; RNA splicing; axonogenesis; cytoplasm; mRNA processing; microtubule depolymerization; nucleus; spliceosomal complex IPR010304; IPR002999; Survival motor neuron protein Smn1 Smn Mus musculus (Mouse) TR3929_c0_g1_i2 P19070 CR2_MOUSE 3.00E-11 GO:0042113; GO:0006958; GO:0004875; GO:0009897; GO:0045087; GO:0016021; GO:0042803 "B cell activation; complement activation, classical pathway; complement receptor activity; external side of plasma membrane; innate immune response; integral to membrane; protein homodimerization activity" IPR000436; Complement receptor type 2 (Cr2) (Complement C3d receptor) (CD antigen CD21) Cr2 Mus musculus (Mouse) TR39290_c2_g1_i1 Q9P2G9 KLHL8_HUMAN 2.00E-17 GO:0031463; GO:0042787 Cul3-RING ubiquitin ligase complex; protein ubiquitination involved in ubiquitin-dependent protein catabolic process IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 8 KLHL8 KIAA1378 Homo sapiens (Human) TR39290_c2_g1_i3 Q6TDP4 KLH17_HUMAN 4.00E-23 GO:0015629; GO:0030036; GO:0007420; GO:0030054; GO:0032839; GO:0043025; GO:0014069; GO:0045211; GO:0032947; GO:0016567 actin cytoskeleton; actin cytoskeleton organization; brain development; cell junction; dendrite cytoplasm; neuronal cell body; postsynaptic density; postsynaptic membrane; protein complex scaffold; protein ubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 17 (Actinfilin) KLHL17 Homo sapiens (Human) TR39290_c2_g1_i4 Q9CR40 KLH28_MOUSE 5.00E-22 IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR015916; IPR017096; IPR006652; Kelch-like protein 28 (BTB/POZ domain-containing protein 5) Klhl28 Btbd5 Mus musculus (Mouse) TR39290_c2_g1_i6 Q6TDP4 KLH17_HUMAN 5.00E-20 GO:0015629; GO:0030036; GO:0007420; GO:0030054; GO:0032839; GO:0043025; GO:0014069; GO:0045211; GO:0032947; GO:0016567 actin cytoskeleton; actin cytoskeleton organization; brain development; cell junction; dendrite cytoplasm; neuronal cell body; postsynaptic density; postsynaptic membrane; protein complex scaffold; protein ubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 17 (Actinfilin) KLHL17 Homo sapiens (Human) TR39290_c3_g1_i2 Q5ZJB7 CHMP7_CHICK 8.00E-53 GO:0000815; GO:0045324; GO:0005634; GO:0008565 ESCRT III complex; late endosome to vacuole transport; nucleus; protein transporter activity IPR005024; Charged multivesicular body protein 7 (Chromatin-modifying protein 7) CHMP7 RCJMB04_19g23 Gallus gallus (Chicken) TR39290_c3_g1_i9 Q5R812 CHMP7_PONAB 2.00E-57 GO:0000815; GO:0045324; GO:0008565 ESCRT III complex; late endosome to vacuole transport; protein transporter activity IPR005024; Charged multivesicular body protein 7 (Chromatin-modifying protein 7) CHMP7 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39294_c0_g1_i2 Q4R6W9 SNPC1_MACFA 3.00E-39 GO:0003677; GO:0005634; GO:0006355; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019188; snRNA-activating protein complex subunit 1 (SNAPc subunit 1) (Small nuclear RNA-activating complex polypeptide 1) (snRNA-activating protein complex 43 kDa subunit) (SNAPc 43 kDa subunit) SNAPC1 QtsA-16981 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR39296_c1_g3_i1 Q2KJG2 UFM1_BOVIN 2.00E-47 GO:0005737; GO:0005634; GO:0071569 cytoplasm; nucleus; protein ufmylation IPR005375; Ubiquitin-fold modifier 1 UFM1 Bos taurus (Bovine) TR39296_c1_g3_i8 Q2KJG2 UFM1_BOVIN 7.00E-48 GO:0005737; GO:0005634; GO:0071569 cytoplasm; nucleus; protein ufmylation IPR005375; Ubiquitin-fold modifier 1 UFM1 Bos taurus (Bovine) TR39297_c1_g1_i2 O97159 CHDM_DROME 2.00E-12 GO:0005524; GO:0004003; GO:0003677; GO:0016581; GO:0048813; GO:0007517; GO:0000122; GO:0031491; GO:0042766; GO:0005700; GO:0006351; GO:0008270 Q9VZ27; Q0E8J0 "ATP binding; ATP-dependent DNA helicase activity; DNA binding; NuRD complex; dendrite morphogenesis; muscle organ development; negative regulation of transcription from RNA polymerase II promoter; nucleosome binding; nucleosome mobilization; polytene chromosome; transcription, DNA-dependent; zinc ion binding" IPR012957; IPR012958; IPR023780; IPR000953; IPR016197; IPR002464; IPR009462; IPR009463; IPR014001; IPR001650; IPR027417; IPR000330; IPR019786; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Chromodomain-helicase-DNA-binding protein Mi-2 homolog (EC 3.6.4.12) (ATP-dependent helicase Mi-2) (dMi-2) Mi-2 CG8103 Drosophila melanogaster (Fruit fly) TR39297_c3_g1_i1 Q14839 CHD4_HUMAN 0 GO:0005524; GO:0004003; GO:0003677; GO:0016581; GO:0005813; GO:0016568; GO:0005737; GO:0006357; GO:0006351; GO:0008270 Q13547; P01106 "ATP binding; ATP-dependent DNA helicase activity; DNA binding; NuRD complex; centrosome; chromatin modification; cytoplasm; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; zinc ion binding" IPR012957; IPR012958; IPR023780; IPR000953; IPR016197; IPR002464; IPR009462; IPR009463; IPR014001; IPR001650; IPR027417; IPR000330; IPR019786; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) CHD4 Homo sapiens (Human) TR39297_c3_g1_i3 Q8K4F6 NSUN5_MOUSE 2.00E-43 GO:0003723; GO:0008168 RNA binding; methyltransferase activity IPR001678; IPR023267; Putative methyltransferase NSUN5 (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein homolog) Nsun5 Wbscr20 Wbscr20a Mus musculus (Mouse) TR39297_c3_g1_i5 G5EBZ4 LE418_CAEEL 0 GO:0005524; GO:0008026; GO:0003677; GO:0016581; GO:0048557; GO:0000122; GO:0040027; GO:0008270 Q21502 ATP binding; ATP-dependent helicase activity; DNA binding; NuRD complex; embryonic digestive tract morphogenesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of vulval development; zinc ion binding IPR012957; IPR012958; IPR023780; IPR000953; IPR016197; IPR002464; IPR009462; IPR009463; IPR014001; IPR001650; IPR027417; IPR000330; IPR019786; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein let-418 (Lethal protein 418) let-418 evl-11 F26F12.7 Caenorhabditis elegans TR39297_c3_g1_i6 Q14839 CHD4_HUMAN 0 GO:0005524; GO:0004003; GO:0003677; GO:0016581; GO:0005813; GO:0016568; GO:0005737; GO:0006357; GO:0006351; GO:0008270 Q13547; P01106 "ATP binding; ATP-dependent DNA helicase activity; DNA binding; NuRD complex; centrosome; chromatin modification; cytoplasm; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; zinc ion binding" IPR012957; IPR012958; IPR023780; IPR000953; IPR016197; IPR002464; IPR009462; IPR009463; IPR014001; IPR001650; IPR027417; IPR000330; IPR019786; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) CHD4 Homo sapiens (Human) TR39299_c0_g2_i1 Q8QGW7 LITAF_CHICK 1.00E-11 GO:0005125; GO:0005737; GO:0006355; GO:0006351 "cytokine activity; cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) TR39300_c10_g1_i1 Q8RWN2 ZIF1_ARATH 9.00E-13 GO:0016021; GO:0009705; GO:0005886; GO:0009624; GO:0010043; GO:0055085; GO:0005215; GO:0055069 integral to membrane; plant-type vacuole membrane; plasma membrane; response to nematode; response to zinc ion; transmembrane transport; transporter activity; zinc ion homeostasis IPR011701; IPR020846; IPR016196; IPR001958; Protein ZINC INDUCED FACILITATOR 1 ZIF1 At5g13740 MSH12.21 Arabidopsis thaliana (Mouse-ear cress) TR39300_c7_g1_i1 Q3EAQ5 PTR36_ARATH 3.00E-11 GO:0016021; GO:0009624; GO:0055085 integral to membrane; response to nematode; transmembrane transport IPR011701; IPR020846; IPR016196; Probable peptide/nitrate transporter At3g43790 (Protein ZINC INDUCED FACILITATOR-LIKE 2) ZIFL2 At3g43790 T28A8.80 Arabidopsis thaliana (Mouse-ear cress) TR39300_c8_g1_i1 Q9CZ15 PSF1_MOUSE 3.00E-72 GO:0006260; GO:0005737; GO:0001833; GO:0005634 DNA replication; cytoplasm; inner cell mass cell proliferation; nucleus IPR005339; DNA replication complex GINS protein PSF1 (GINS complex subunit 1) Gins1 Psf1 Mus musculus (Mouse) TR39300_c8_g2_i1 Q6P1U2 TTYH2_XENTR 8.00E-30 GO:0005254; GO:0034707; GO:0005886 chloride channel activity; chloride channel complex; plasma membrane IPR006990; Protein tweety homolog 2 ttyh2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39300_c8_g2_i2 Q6P5F7 TTYH3_MOUSE 1.00E-20 GO:0005254; GO:0034707; GO:0005886 chloride channel activity; chloride channel complex; plasma membrane IPR006990; Protein tweety homolog 3 (mTTY3) Ttyh3 Kiaa1691 Mus musculus (Mouse) TR39300_c8_g2_i4 Q6P1U2 TTYH2_XENTR 7.00E-30 GO:0005254; GO:0034707; GO:0005886 chloride channel activity; chloride channel complex; plasma membrane IPR006990; Protein tweety homolog 2 ttyh2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39300_c8_g2_i8 Q9U6L4 TTY1_DROME 6.00E-20 GO:0005254; GO:0034707; GO:0005886 chloride channel activity; chloride channel complex; plasma membrane IPR006990; Protein tweety (Dttyh1) tty CG1693 Drosophila melanogaster (Fruit fly) TR39300_c8_g2_i9 Q6P1U2 TTYH2_XENTR 8.00E-30 GO:0005254; GO:0034707; GO:0005886 chloride channel activity; chloride channel complex; plasma membrane IPR006990; Protein tweety homolog 2 ttyh2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39301_c5_g1_i6 P19477 FIBA_PARPA 4.00E-50 IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein A (FREP-A) Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) TR39301_c5_g1_i8 Q8VCM7 FIBG_MOUSE 1.00E-26 GO:0005938; GO:0009897; GO:0005577; GO:0046872; GO:0030168; GO:0031091; GO:0051258; GO:0051592; GO:0007165 cell cortex; external side of plasma membrane; fibrinogen complex; metal ion binding; platelet activation; platelet alpha granule; protein polymerization; response to calcium ion; signal transduction IPR014716; IPR014715; IPR002181; IPR012290; IPR020837; Fibrinogen gamma chain Fgg Mus musculus (Mouse) TR39302_c3_g1_i1 A4K2V0 TOM34_PONAB 3.00E-10 GO:0005741; GO:0006626 mitochondrial outer membrane; protein targeting to mitochondrion IPR013026; IPR011990; IPR001440; IPR013105; IPR019734; Mitochondrial import receptor subunit TOM34 (Translocase of outer membrane 34 kDa subunit) TOMM34 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39302_c4_g1_i1 Q5UQY4 YR886_MIMIV 5.00E-12 IPR002110; IPR020683; Putative ankyrin repeat protein R886 (Fragment) MIMI_R886 Acanthamoeba polyphaga mimivirus (APMV) TR39302_c4_g7_i1 A1X154 ASZ1_ECHTE 8.00E-12 GO:0043046; GO:0030154; GO:0031047; GO:0007140; GO:0007275; GO:0071546; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; cell differentiation; gene silencing by RNA; male meiosis; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002110; IPR020683; IPR013761; IPR011510; "Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)" ASZ1 GASZ Echinops telfairi (Lesser hedgehog tenrec) TR39302_c4_g7_i10 Q5UP11 YR848_MIMIV 6.00E-19 IPR002110; IPR020683; Putative ankyrin repeat protein R848 MIMI_R848 Acanthamoeba polyphaga mimivirus (APMV) TR39302_c4_g7_i11 Q9STP8 ACBP2_ARATH 4.00E-09 GO:0005783; GO:0005789; GO:0000062; GO:0009514; GO:0016021; GO:0032791; GO:0008289; GO:0006869; GO:0005778; GO:0005886; GO:0010288 Q9SZN7; P42736 endoplasmic reticulum; endoplasmic reticulum membrane; fatty-acyl-CoA binding; glyoxysome; integral to membrane; lead ion binding; lipid binding; lipid transport; peroxisomal membrane; plasma membrane; response to lead ion IPR000582; IPR002110; IPR020683; IPR014352; Acyl-CoA-binding domain-containing protein 2 (Acyl-CoA binding protein 2) ACBP2 At4g27780 T27E11.20 Arabidopsis thaliana (Mouse-ear cress) TR39302_c4_g7_i12 Q8TC84 FANK1_HUMAN 4.00E-20 GO:0005737; GO:0005634 cytoplasm; nucleus IPR002110; IPR020683; IPR003961; IPR013783; Fibronectin type 3 and ankyrin repeat domains protein 1 FANK1 HSD13 UNQ6504/PRO21382 Homo sapiens (Human) TR39302_c4_g7_i2 Q8K3X6 ANS4B_MOUSE 1.00E-08 GO:0005886 plasma membrane IPR002110; IPR020683; IPR001660; IPR013761; IPR021129; Ankyrin repeat and SAM domain-containing protein 4B (Harmonin-interacting ankyrin repeat-containing protein) (Harp) Anks4b Harp Mus musculus (Mouse) TR39302_c4_g7_i3 Q9CZK6 ANKS3_MOUSE 2.00E-13 IPR002110; IPR020683; IPR001660; IPR013761; IPR011510; Ankyrin repeat and SAM domain-containing protein 3 Anks3 Kiaa1977 Mus musculus (Mouse) TR39302_c4_g7_i4 Q5DW34 EHMT1_MOUSE 6.00E-20 GO:0006306; GO:0005694; GO:0009790; GO:0046976; GO:0046974; GO:0000122; GO:0005634; GO:0018027; GO:0018026; GO:0008270 DNA methylation; chromosome; embryo development; histone methyltransferase activity (H3-K27 specific); histone methyltransferase activity (H3-K9 specific); negative regulation of transcription from RNA polymerase II promoter; nucleus; peptidyl-lysine dimethylation; peptidyl-lysine monomethylation; zinc ion binding IPR002110; IPR020683; IPR007728; IPR003606; IPR001214; Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Lysine N-methyltransferase 1D) Ehmt1 Euhmtase1 Glp Kmt1d Mus musculus (Mouse) TR39302_c4_g7_i5 Q9ULH0 KDIS_HUMAN 4.00E-18 GO:0030165; GO:0000186; GO:0016482; GO:0005829; GO:0048813; GO:0001701; GO:0016021; GO:0005770; GO:0038180; GO:0048011; GO:0010976; GO:0043234 PDZ domain binding; activation of MAPKK activity; cytoplasmic transport; cytosol; dendrite morphogenesis; in utero embryonic development; integral to membrane; late endosome; nerve growth factor signaling pathway; neurotrophin TRK receptor signaling pathway; positive regulation of neuron projection development; protein complex IPR002110; IPR020683; IPR011646; IPR013761; Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) KIDINS220 ARMS KIAA1250 Homo sapiens (Human) TR39302_c4_g7_i6 Q07E30 ASZ1_NEONE 9.00E-14 GO:0043046; GO:0030154; GO:0031047; GO:0007140; GO:0007275; GO:0071546; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; cell differentiation; gene silencing by RNA; male meiosis; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002110; IPR020683; IPR013761; IPR011510; "Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)" ASZ1 GASZ Neofelis nebulosa (Clouded leopard) TR39302_c4_g7_i7 Q54HW1 PSD10_DICDI 7.00E-15 IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) psmD10 DDB_G0289189 Dictyostelium discoideum (Slime mold) TR39302_c4_g7_i9 Q74ZH9 GDE1_ASHGO 1.00E-08 GO:0006071; GO:0047389; GO:0008889; GO:0046475; GO:0005840 glycerol metabolic process; glycerophosphocholine phosphodiesterase activity; glycerophosphodiester phosphodiesterase activity; glycerophospholipid catabolic process; ribosome IPR002110; IPR020683; IPR004129; IPR017946; IPR000909; IPR004331; Glycerophosphodiester phosphodiesterase GDE1 (EC 3.1.4.46) GDE1 AGR223W Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR39303_c1_g1_i2 Q9Y345 SC6A5_HUMAN 5.00E-157 GO:0015375; GO:0016021; GO:0005328; GO:0005886; GO:0007268 glycine:sodium symporter activity; integral to membrane; neurotransmitter:sodium symporter activity; plasma membrane; synaptic transmission IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) TR39303_c1_g1_i3 Q9Y345 SC6A5_HUMAN 7.00E-24 GO:0015375; GO:0016021; GO:0005328; GO:0005886; GO:0007268 glycine:sodium symporter activity; integral to membrane; neurotransmitter:sodium symporter activity; plasma membrane; synaptic transmission IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) TR39304_c0_g1_i1 P01008 ANT3_HUMAN 2.00E-53 GO:0007596; GO:0005615; GO:0008201; GO:0050728; GO:0005886; GO:2000266; GO:0030162; GO:0007584; GO:0004867 "blood coagulation; extracellular space; heparin binding; negative regulation of inflammatory response; plasma membrane; regulation of blood coagulation, intrinsic pathway; regulation of proteolysis; response to nutrient; serine-type endopeptidase inhibitor activity" IPR015555; IPR023795; IPR023796; IPR000215; Antithrombin-III (ATIII) (Serpin C1) SERPINC1 AT3 PRO0309 Homo sapiens (Human) TR39305_c0_g1_i1 P51992 RO32_XENLA 3.00E-32 GO:0003723; GO:0000166; GO:0005634; GO:0030529 RNA binding; nucleotide binding; nucleus; ribonucleoprotein complex IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein A3 homolog 2 (hnRNP A3(B)) Xenopus laevis (African clawed frog) TR39305_c0_g1_i10 P49311 GRP2_SINAL 4.00E-13 GO:0003723; GO:0000166; GO:0005634 RNA binding; nucleotide binding; nucleus IPR012677; IPR000504; Glycine-rich RNA-binding protein GRP2A Sinapis alba (White mustard) (Brassica hirta) TR39305_c0_g1_i11 Q96EP5 DAZP1_HUMAN 4.00E-57 GO:0003723; GO:0035613; GO:0030154; GO:0008283; GO:0005737; GO:0001893; GO:0000166; GO:0005634; GO:0007283 RNA binding; RNA stem-loop binding; cell differentiation; cell proliferation; cytoplasm; maternal placenta development; nucleotide binding; nucleus; spermatogenesis IPR012677; IPR000504; DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) DAZAP1 Homo sapiens (Human) TR39305_c0_g1_i2 P28644 ROC1_SPIOL 6.00E-24 GO:0003723; GO:0009507; GO:0006397; GO:0000166; GO:0030529 RNA binding; chloroplast; mRNA processing; nucleotide binding; ribonucleoprotein complex IPR012677; IPR000504; "28 kDa ribonucleoprotein, chloroplastic (28RNP)" Spinacia oleracea (Spinach) TR39305_c0_g1_i3 Q2HJ60 ROA2_BOVIN 8.00E-33 GO:0003723; GO:0008380; GO:0050658; GO:0071013; GO:0005737; GO:0006397; GO:0005730; GO:0005654; GO:0000166; GO:0030529; GO:0043047 RNA binding; RNA splicing; RNA transport; catalytic step 2 spliceosome; cytoplasm; mRNA processing; nucleolus; nucleoplasm; nucleotide binding; ribonucleoprotein complex; single-stranded telomeric DNA binding IPR012677; IPR000504; Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) HNRNPA2B1 HNRPA2B1 Bos taurus (Bovine) TR39305_c0_g1_i4 Q96EP5 DAZP1_HUMAN 1.00E-55 GO:0003723; GO:0035613; GO:0030154; GO:0008283; GO:0005737; GO:0001893; GO:0000166; GO:0005634; GO:0007283 RNA binding; RNA stem-loop binding; cell differentiation; cell proliferation; cytoplasm; maternal placenta development; nucleotide binding; nucleus; spermatogenesis IPR012677; IPR000504; DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) DAZAP1 Homo sapiens (Human) TR39305_c0_g1_i6 P28644 ROC1_SPIOL 4.00E-23 GO:0003723; GO:0009507; GO:0006397; GO:0000166; GO:0030529 RNA binding; chloroplast; mRNA processing; nucleotide binding; ribonucleoprotein complex IPR012677; IPR000504; "28 kDa ribonucleoprotein, chloroplastic (28RNP)" Spinacia oleracea (Spinach) TR39305_c0_g1_i7 P19683 ROC4_NICSY 4.00E-19 GO:0003723; GO:0009507; GO:0006397; GO:0000166; GO:0030529 RNA binding; chloroplast; mRNA processing; nucleotide binding; ribonucleoprotein complex IPR012677; IPR000504; "31 kDa ribonucleoprotein, chloroplastic" Nicotiana sylvestris (Wood tobacco) (South American tobacco) TR39305_c0_g1_i8 A7VJC2 ROA2_RAT 3.00E-32 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0005654; GO:0000166; GO:0030529; GO:0005681 RNA binding; RNA splicing; cytoplasm; mRNA processing; nucleoplasm; nucleotide binding; ribonucleoprotein complex; spliceosomal complex IPR012677; IPR000504; Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) Hnrnpa2b1 Hnrnp Hnrpa2b1 Rattus norvegicus (Rat) TR39305_c0_g1_i9 Q96EP5 DAZP1_HUMAN 3.00E-57 GO:0003723; GO:0035613; GO:0030154; GO:0008283; GO:0005737; GO:0001893; GO:0000166; GO:0005634; GO:0007283 RNA binding; RNA stem-loop binding; cell differentiation; cell proliferation; cytoplasm; maternal placenta development; nucleotide binding; nucleus; spermatogenesis IPR012677; IPR000504; DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) DAZAP1 Homo sapiens (Human) TR39305_c0_g2_i1 Q02926 RB97D_DROME 3.00E-20 GO:0003729; GO:0007275; GO:0000166; GO:0007286 mRNA binding; multicellular organismal development; nucleotide binding; spermatid development IPR012677; IPR000504; Ribonucleoprotein RB97D Rb97D Hrb97D CG6354 Drosophila melanogaster (Fruit fly) TR39307_c0_g2_i1 Q5RDY2 TM9S4_PONAB 0 GO:0016021 integral to membrane IPR004240; Transmembrane 9 superfamily member 4 TM9SF4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39308_c4_g4_i1 Q27889 PP2B2_DROME 0 GO:0005955; GO:0005516; GO:0033192; GO:0009790; GO:0007143; GO:0046872; GO:0006470; GO:0030431; GO:0035220 calcineurin complex; calmodulin binding; calmodulin-dependent protein phosphatase activity; embryo development; female meiosis; metal ion binding; protein dephosphorylation; sleep; wing disc development IPR004843; IPR006186; Serine/threonine-protein phosphatase 2B catalytic subunit 2 (EC 3.1.3.16) (Calmodulin-dependent calcineurin A2 subunit) Pp2B-14D CG9842 Drosophila melanogaster (Fruit fly) TR39308_c4_g4_i2 P63329 PP2BA_RAT 0 GO:0000082; GO:0030018; GO:0005955; GO:0033173; GO:0006816; GO:0005516; GO:0033192; GO:0035690; GO:0071333; GO:0005829; GO:0008144; GO:0016020; GO:0046872; GO:0005739; GO:0045955; GO:0046676; GO:0005634; GO:0045944; GO:0006470; GO:0046982; GO:0006606; GO:0060079; GO:0050804; GO:0001975; GO:0051592; GO:0006950; GO:0048741; GO:0014883 P22002 G1/S transition of mitotic cell cycle; Z disc; calcineurin complex; calcineurin-NFAT signaling cascade; calcium ion transport; calmodulin binding; calmodulin-dependent protein phosphatase activity; cellular response to drug; cellular response to glucose stimulus; cytosol; drug binding; membrane; metal ion binding; mitochondrion; negative regulation of calcium ion-dependent exocytosis; negative regulation of insulin secretion; nucleus; positive regulation of transcription from RNA polymerase II promoter; protein dephosphorylation; protein heterodimerization activity; protein import into nucleus; regulation of excitatory postsynaptic membrane potential; regulation of synaptic transmission; response to amphetamine; response to calcium ion; response to stress; skeletal muscle fiber development; transition between fast and slow fiber IPR004843; IPR006186; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit alpha isoform) Ppp3ca Calna Rattus norvegicus (Rat) TR39309_c1_g1_i1 O18778 PAHX_BOVIN 7.00E-06 GO:0031418; GO:0006631; GO:0046872; GO:0005777; GO:0048244 L-ascorbic acid binding; fatty acid metabolic process; metal ion binding; peroxisome; phytanoyl-CoA dioxygenase activity IPR008775; Lipid metabolism; fatty acid metabolism. "Phytanoyl-CoA dioxygenase, peroxisomal (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH)" PHYH LN1 PAHX Bos taurus (Bovine) TR39309_c1_g1_i3 Q5U3U0 PHYD1_DANRE 2.00E-95 GO:0051213; GO:0046872 dioxygenase activity; metal ion binding IPR008775; Phytanoyl-CoA dioxygenase domain-containing protein 1 (EC 1.-.-.-) phyhd1 zgc:101639 Danio rerio (Zebrafish) (Brachydanio rerio) TR39309_c1_g1_i7 Q5BJP9 PHYD1_RAT 4.00E-92 GO:0051213; GO:0046872 dioxygenase activity; metal ion binding IPR008775; Phytanoyl-CoA dioxygenase domain-containing protein 1 (EC 1.-.-.-) Phyhd1 Rattus norvegicus (Rat) TR39310_c0_g1_i3 Q2R4J1 GDT13_ORYSJ 4.00E-49 GO:0016021 integral to membrane IPR001727; GDT1-like protein 3 Os11g0472500 LOC_Os11g28300 OsJ_33855 Oryza sativa subsp. japonica (Rice) TR39310_c0_g1_i4 Q9HC07 TM165_HUMAN 2.00E-100 GO:0005794; GO:0032472; GO:0000139; GO:0006874; GO:0031901; GO:0010008; GO:0016021; GO:0031902; GO:0005765; GO:0006487; GO:0035751; GO:0032588 Golgi apparatus; Golgi calcium ion transport; Golgi membrane; cellular calcium ion homeostasis; early endosome membrane; endosome membrane; integral to membrane; late endosome membrane; lysosomal membrane; protein N-linked glycosylation; regulation of lysosomal lumen pH; trans-Golgi network membrane IPR001727; Transmembrane protein 165 (Transmembrane protein PT27) (Transmembrane protein TPARL) TMEM165 TPARL Homo sapiens (Human) TR39311_c4_g3_i1 Q6J1I7 RN166_RAT 4.00E-62 GO:0008270 zinc ion binding IPR008598; IPR015880; IPR001841; IPR013083; IPR017907; RING finger protein 166 Rnf166 Rattus norvegicus (Rat) TR39311_c7_g3_i1 A7MBI0 PACN1_BOVIN 3.00E-16 GO:0030137; GO:0043679; GO:0030054; GO:0005737; GO:0030659; GO:0005829; GO:0097320; GO:0045806; GO:0048812; GO:0005543; GO:0072657; GO:0032587; GO:0045202; GO:0048488 COPI-coated vesicle; axon terminus; cell junction; cytoplasm; cytoplasmic vesicle membrane; cytosol; membrane tubulation; negative regulation of endocytosis; neuron projection morphogenesis; phospholipid binding; protein localization to membrane; ruffle membrane; synapse; synaptic vesicle endocytosis IPR001060; IPR001452; Protein kinase C and casein kinase substrate in neurons protein 1 PACSIN1 Bos taurus (Bovine) TR39311_c7_g3_i2 O13154 PACN2_CHICK 8.00E-18 GO:0005901; GO:0030659; GO:0008092; GO:0005856; GO:0005829; GO:0005769; GO:0006897; GO:0005925; GO:0045806; GO:0070300; GO:0032587 caveola; cytoplasmic vesicle membrane; cytoskeletal protein binding; cytoskeleton; cytosol; early endosome; endocytosis; focal adhesion; negative regulation of endocytosis; phosphatidic acid binding; ruffle membrane IPR001060; IPR001452; Protein kinase C and casein kinase substrate in neurons protein 2 (Focal adhesion protein of 52 kDa) (FAP52) PACSIN2 Gallus gallus (Chicken) TR39311_c7_g3_i4 O13154 PACN2_CHICK 6.00E-17 GO:0005901; GO:0030659; GO:0008092; GO:0005856; GO:0005829; GO:0005769; GO:0006897; GO:0005925; GO:0045806; GO:0070300; GO:0032587 caveola; cytoplasmic vesicle membrane; cytoskeletal protein binding; cytoskeleton; cytosol; early endosome; endocytosis; focal adhesion; negative regulation of endocytosis; phosphatidic acid binding; ruffle membrane IPR001060; IPR001452; Protein kinase C and casein kinase substrate in neurons protein 2 (Focal adhesion protein of 52 kDa) (FAP52) PACSIN2 Gallus gallus (Chicken) TR39312_c0_g3_i2 Q96MU6 ZN778_HUMAN 1.00E-63 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 778 ZNF778 Homo sapiens (Human) TR39312_c0_g3_i3 Q86V71 ZN429_HUMAN 8.00E-64 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 429 ZNF429 Homo sapiens (Human) TR39312_c0_g3_i6 Q4V8A8 ZFP90_RAT 5.00E-60 GO:0003677; GO:0001078; GO:0046872; GO:0043392; GO:0005634; GO:0045893 "DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; metal ion binding; negative regulation of DNA binding; nucleus; positive regulation of transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 90 (Zfp-90) Zfp90 Rattus norvegicus (Rat) TR39312_c0_g3_i8 Q03936 ZNF92_HUMAN 1.00E-11 GO:0003677; GO:0005634; GO:0003700; GO:0006351; GO:0008270 "DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 92 (Zinc finger protein HTF12) ZNF92 Homo sapiens (Human) TR39314_c2_g2_i1 P41992 GGTB2_CAEEL 3.00E-36 GO:0004663; GO:0046872; GO:0018344 Rab geranylgeranyltransferase activity; metal ion binding; protein geranylgeranylation IPR001330; IPR026873; IPR008930; Probable geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta) ggtb-1 B0280.1 Caenorhabditis elegans TR39314_c2_g2_i2 P53610 PGTB1_RAT 9.00E-156 GO:0004662; GO:0005953; GO:0046872; GO:0051771; GO:0045787; GO:0008284; GO:0018344; GO:0034097 Q04631 CAAX-protein geranylgeranyltransferase activity; CAAX-protein geranylgeranyltransferase complex; metal ion binding; negative regulation of nitric-oxide synthase biosynthetic process; positive regulation of cell cycle; positive regulation of cell proliferation; protein geranylgeranylation; response to cytokine stimulus IPR001330; IPR008930; Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta) Pggt1b Rattus norvegicus (Rat) TR39316_c1_g1_i1 Q9YHY6 CND1_XENLA 0 GO:0051301; GO:0005694; GO:0005829; GO:0007076; GO:0005634 cell division; chromosome; cytosol; mitotic chromosome condensation; nucleus IPR011989; IPR016024; IPR026971; IPR007673; IPR024324; Condensin complex subunit 1 (Chromosome assembly protein XCAP-D2) (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (Eg7) (Non-SMC condensin I complex subunit D2) ncapd2 capd2 cnap1 eg7 Xenopus laevis (African clawed frog) TR39316_c1_g1_i4 Q9YHY6 CND1_XENLA 0 GO:0051301; GO:0005694; GO:0005829; GO:0007076; GO:0005634 cell division; chromosome; cytosol; mitotic chromosome condensation; nucleus IPR011989; IPR016024; IPR026971; IPR007673; IPR024324; Condensin complex subunit 1 (Chromosome assembly protein XCAP-D2) (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (Eg7) (Non-SMC condensin I complex subunit D2) ncapd2 capd2 cnap1 eg7 Xenopus laevis (African clawed frog) TR39318_c2_g2_i5 P56276 MYLK_MELGA 7.00E-16 IPR007110; IPR013783; IPR013098; IPR003598; IPR020675; Telokin Meleagris gallopavo (Common turkey) TR39319_c0_g2_i1 Q8SR85 CDC71_ENCCU 3.00E-12 GO:0005524; GO:0051301; GO:0007126; GO:0046872; GO:0007067; GO:0004674 ATP binding; cell division; meiosis; metal ion binding; mitosis; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Probable cell division control protein 7 homolog 1 (EC 2.7.11.1) CDC7-1 ECU08_1960 Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) TR39319_c0_g3_i2 P28020 CSK21_XENLA 3.00E-97 GO:0005524; GO:0016055; GO:0004674 ATP binding; Wnt receptor signaling pathway; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Casein kinase II subunit alpha (CK II) (EC 2.7.11.1) csnk2a1 Xenopus laevis (African clawed frog) TR39319_c0_g3_i3 O76484 CSK2A_SPOFR 1.00E-18 GO:0005524; GO:0016055; GO:0004674 ATP binding; Wnt receptor signaling pathway; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Casein kinase II subunit alpha (CK II subunit alpha) (EC 2.7.11.1) Spodoptera frugiperda (Fall armyworm) TR39319_c0_g3_i7 P28020 CSK21_XENLA 3.00E-97 GO:0005524; GO:0016055; GO:0004674 ATP binding; Wnt receptor signaling pathway; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Casein kinase II subunit alpha (CK II) (EC 2.7.11.1) csnk2a1 Xenopus laevis (African clawed frog) TR39319_c0_g4_i1 P28523 CSK2A_MAIZE 2.00E-82 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Casein kinase II subunit alpha (EC 2.7.11.1) (CK II) (CK2-alpha) ACK2 Zea mays (Maize) TR39321_c0_g1_i1 P05202 AATM_MOUSE 0 GO:0004069; GO:0080130; GO:0006532; GO:0006533; GO:0015908; GO:0019551; GO:0019550; GO:0016212; GO:0005743; GO:0005759; GO:0006107; GO:0005886; GO:0030170; GO:0045471 L-aspartate:2-oxoglutarate aminotransferase activity; L-phenylalanine:2-oxoglutarate aminotransferase activity; aspartate biosynthetic process; aspartate catabolic process; fatty acid transport; glutamate catabolic process to 2-oxoglutarate; glutamate catabolic process to aspartate; kynurenine-oxoglutarate transaminase activity; mitochondrial inner membrane; mitochondrial matrix; oxaloacetate metabolic process; plasma membrane; pyridoxal phosphate binding; response to ethanol IPR004839; IPR000796; IPR004838; IPR015424; IPR015421; "Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A)" Got2 Got-2 Mus musculus (Mouse) TR39321_c0_g1_i3 O94320 AATM_SCHPO 2.00E-153 GO:0006103; GO:0004069; GO:0080130; GO:0019266; GO:0006532; GO:0006533; GO:0006534; GO:0006536; GO:0005759; GO:0030170 2-oxoglutarate metabolic process; L-aspartate:2-oxoglutarate aminotransferase activity; L-phenylalanine:2-oxoglutarate aminotransferase activity; asparagine biosynthetic process from oxaloacetate; aspartate biosynthetic process; aspartate catabolic process; cysteine metabolic process; glutamate metabolic process; mitochondrial matrix; pyridoxal phosphate binding IPR004839; IPR000796; IPR004838; IPR015424; IPR015421; "Aspartate aminotransferase, mitochondrial (EC 2.6.1.1) (Transaminase A)" SPBC725.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR39321_c0_g1_i5 P12345 AATM_RABIT 9.00E-07 GO:0006103; GO:0004069; GO:0080130; GO:0006532; GO:0006533; GO:0006531; GO:0015908; GO:0019551; GO:0019550; GO:0006536; GO:0016212; GO:0005743; GO:0005759; GO:0005739; GO:0006107; GO:0005886; GO:0006457; GO:0030170; GO:0045471 2-oxoglutarate metabolic process; L-aspartate:2-oxoglutarate aminotransferase activity; L-phenylalanine:2-oxoglutarate aminotransferase activity; aspartate biosynthetic process; aspartate catabolic process; aspartate metabolic process; fatty acid transport; glutamate catabolic process to 2-oxoglutarate; glutamate catabolic process to aspartate; glutamate metabolic process; kynurenine-oxoglutarate transaminase activity; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; oxaloacetate metabolic process; plasma membrane; protein folding; pyridoxal phosphate binding; response to ethanol IPR004839; IPR000796; IPR004838; IPR015424; IPR015421; "Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A)" GOT2 Oryctolagus cuniculus (Rabbit) TR39321_c0_g1_i6 P05202 AATM_MOUSE 0 GO:0004069; GO:0080130; GO:0006532; GO:0006533; GO:0015908; GO:0019551; GO:0019550; GO:0016212; GO:0005743; GO:0005759; GO:0006107; GO:0005886; GO:0030170; GO:0045471 L-aspartate:2-oxoglutarate aminotransferase activity; L-phenylalanine:2-oxoglutarate aminotransferase activity; aspartate biosynthetic process; aspartate catabolic process; fatty acid transport; glutamate catabolic process to 2-oxoglutarate; glutamate catabolic process to aspartate; kynurenine-oxoglutarate transaminase activity; mitochondrial inner membrane; mitochondrial matrix; oxaloacetate metabolic process; plasma membrane; pyridoxal phosphate binding; response to ethanol IPR004839; IPR000796; IPR004838; IPR015424; IPR015421; "Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A)" Got2 Got-2 Mus musculus (Mouse) TR39321_c0_g1_i7 P12345 AATM_RABIT 2.00E-07 GO:0006103; GO:0004069; GO:0080130; GO:0006532; GO:0006533; GO:0006531; GO:0015908; GO:0019551; GO:0019550; GO:0006536; GO:0016212; GO:0005743; GO:0005759; GO:0005739; GO:0006107; GO:0005886; GO:0006457; GO:0030170; GO:0045471 2-oxoglutarate metabolic process; L-aspartate:2-oxoglutarate aminotransferase activity; L-phenylalanine:2-oxoglutarate aminotransferase activity; aspartate biosynthetic process; aspartate catabolic process; aspartate metabolic process; fatty acid transport; glutamate catabolic process to 2-oxoglutarate; glutamate catabolic process to aspartate; glutamate metabolic process; kynurenine-oxoglutarate transaminase activity; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; oxaloacetate metabolic process; plasma membrane; protein folding; pyridoxal phosphate binding; response to ethanol IPR004839; IPR000796; IPR004838; IPR015424; IPR015421; "Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A)" GOT2 Oryctolagus cuniculus (Rabbit) TR39322_c1_g1_i3 P34457 YMD3_CAEEL 6.00E-29 GO:0015074; GO:0003676 DNA integration; nucleic acid binding IPR001584; IPR012337; Putative uncharacterized transposon-derived protein F54H12.3 F54H12.3 Caenorhabditis elegans TR39323_c3_g1_i1 Q0IUU4 CML2_ORYSJ 4.00E-32 GO:0005509; GO:0016020 calcium ion binding; membrane IPR011992; IPR018247; IPR002048; Putative calmodulin-like protein 2 CML2 Os11g0134400 LOC_Os11g03980 OsJ_031538 Oryza sativa subsp. japonica (Rice) TR39323_c3_g1_i2 Q95NI4 CALM_HALOK 3.00E-44 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Halichondria okadai (Marine sponge) (Reniera okadai) TR39323_c3_g1_i3 P54680 FIMB_DICDI 3.00E-12 GO:0051015; GO:0051017; GO:0005509; GO:0030027; GO:0001891; GO:0045335; GO:0019953 actin filament binding; actin filament bundle assembly; calcium ion binding; lamellipodium; phagocytic cup; phagocytic vesicle; sexual reproduction IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; Fimbrin fimA DDB_G0277855 Dictyostelium discoideum (Slime mold) TR39323_c3_g1_i6 Q0IUU4 CML2_ORYSJ 4.00E-32 GO:0005509; GO:0016020 calcium ion binding; membrane IPR011992; IPR018247; IPR002048; Putative calmodulin-like protein 2 CML2 Os11g0134400 LOC_Os11g03980 OsJ_031538 Oryza sativa subsp. japonica (Rice) TR39323_c3_g1_i7 O96081 CALMB_HALRO 2.00E-44 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-B (CaM B) Halocynthia roretzi (Sea squirt) TR39323_c3_g1_i8 P05934 CALM_STRPU 2.00E-19 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) (Fragment) Strongylocentrotus purpuratus (Purple sea urchin) TR39325_c0_g1_i4 P38748 ETP1_YEAST 1.00E-05 GO:0005737; GO:0008139; GO:0045471; GO:0043130; GO:0008270 cytoplasm; nuclear localization sequence binding; response to ethanol; ubiquitin binding; zinc ion binding IPR011422; IPR001841; IPR013083; IPR001607; RING finger protein ETP1 (BRAP2 homolog) (Ethanol tolerance protein 1) ETP1 YHL010C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39327_c2_g1_i2 Q6AYH2 IN80E_RAT 1.00E-11 GO:0006310; GO:0006281; GO:0006260; GO:0031011; GO:0005730; GO:0006355; GO:0006351 "DNA recombination; DNA repair; DNA replication; Ino80 complex; nucleolus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR026678; INO80 complex subunit E (Coiled-coil domain-containing protein 95) Ino80e Ccdc95 Rattus norvegicus (Rat) TR39328_c0_g3_i2 Q5PT53 NTCP7_MOUSE 1.00E-117 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR016833; Sodium/bile acid cotransporter 7 (Na(+)/bile acid cotransporter 7) (Solute carrier family 10 member 7) Slc10a7 P7 Mus musculus (Mouse) TR39328_c0_g3_i4 P39879 Y2026_PSEAE 1.00E-19 IPR016833; Uncharacterized protein PA2026 PA2026 Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) TR39332_c5_g1_i1 Q6IQE0 PU60B_DANRE 4.00E-151 GO:0003677; GO:0003723; GO:0008380; GO:0006915; GO:0006397; GO:0000166; GO:0005634; GO:0006355; GO:0030529; GO:0006351 "DNA binding; RNA binding; RNA splicing; apoptotic process; mRNA processing; nucleotide binding; nucleus; regulation of transcription, DNA-dependent; ribonucleoprotein complex; transcription, DNA-dependent" IPR012677; IPR006532; IPR000504; Poly(U)-binding-splicing factor PUF60-B puf60b puf60 si:zc12p8.2 zgc:86806 Danio rerio (Zebrafish) (Brachydanio rerio) TR39332_c5_g1_i2 Q9WV25 PUF60_RAT 3.00E-174 GO:0003677; GO:0003723; GO:0008380; GO:0006915; GO:0019907; GO:0006397; GO:0000166; GO:0006355; GO:0030529; GO:0006351 "DNA binding; RNA binding; RNA splicing; apoptotic process; cyclin-dependent protein kinase activating kinase holoenzyme complex; mRNA processing; nucleotide binding; regulation of transcription, DNA-dependent; ribonucleoprotein complex; transcription, DNA-dependent" IPR012677; IPR006532; IPR000504; Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (RNA-binding protein Siah-BP) (Siah-binding protein 1) Puf60 Siahbp1 Rattus norvegicus (Rat) TR39332_c5_g1_i3 Q6DEY7 EPAB_XENTR 2.00E-13 GO:0043009; GO:0005737; GO:0031370; GO:0006397; GO:0048255; GO:0060212; GO:0000166; GO:0008143; GO:0043621; GO:0006412 chordate embryonic development; cytoplasm; eukaryotic initiation factor 4G binding; mRNA processing; mRNA stabilization; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; nucleotide binding; poly(A) RNA binding; protein self-association; translation IPR012677; IPR006515; IPR002004; IPR000504; Embryonic polyadenylate-binding protein (Embryonic poly(A)-binding protein) (ePABP) epabp Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39332_c5_g1_i4 Q9WV25 PUF60_RAT 2.00E-172 GO:0003677; GO:0003723; GO:0008380; GO:0006915; GO:0019907; GO:0006397; GO:0000166; GO:0006355; GO:0030529; GO:0006351 "DNA binding; RNA binding; RNA splicing; apoptotic process; cyclin-dependent protein kinase activating kinase holoenzyme complex; mRNA processing; nucleotide binding; regulation of transcription, DNA-dependent; ribonucleoprotein complex; transcription, DNA-dependent" IPR012677; IPR006532; IPR000504; Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (RNA-binding protein Siah-BP) (Siah-binding protein 1) Puf60 Siahbp1 Rattus norvegicus (Rat) TR39332_c5_g1_i7 Q8T6B9 PUF68_DROME 7.00E-103 GO:0000380; GO:0071013; GO:0007282; GO:0003729; GO:0006376; GO:0022008; GO:0000166; GO:0048477; GO:0008266; GO:0071011; GO:0043234; GO:0000381; GO:0001558 "alternative mRNA splicing, via spliceosome; catalytic step 2 spliceosome; cystoblast division; mRNA binding; mRNA splice site selection; neurogenesis; nucleotide binding; oogenesis; poly(U) RNA binding; precatalytic spliceosome; protein complex; regulation of alternative mRNA splicing, via spliceosome; regulation of cell growth" IPR012677; IPR006532; IPR000504; Poly(U)-binding-splicing factor half pint (Protein half pint) (68 kDa poly(U)-binding-splicing factor) (PUF60 homolog) pUf68 hfp CG12085 Drosophila melanogaster (Fruit fly) TR39332_c5_g1_i8 Q9WV25 PUF60_RAT 1.00E-175 GO:0003677; GO:0003723; GO:0008380; GO:0006915; GO:0019907; GO:0006397; GO:0000166; GO:0006355; GO:0030529; GO:0006351 "DNA binding; RNA binding; RNA splicing; apoptotic process; cyclin-dependent protein kinase activating kinase holoenzyme complex; mRNA processing; nucleotide binding; regulation of transcription, DNA-dependent; ribonucleoprotein complex; transcription, DNA-dependent" IPR012677; IPR006532; IPR000504; Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (RNA-binding protein Siah-BP) (Siah-binding protein 1) Puf60 Siahbp1 Rattus norvegicus (Rat) TR39332_c5_g1_i9 Q6DEY7 EPAB_XENTR 2.00E-13 GO:0043009; GO:0005737; GO:0031370; GO:0006397; GO:0048255; GO:0060212; GO:0000166; GO:0008143; GO:0043621; GO:0006412 chordate embryonic development; cytoplasm; eukaryotic initiation factor 4G binding; mRNA processing; mRNA stabilization; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; nucleotide binding; poly(A) RNA binding; protein self-association; translation IPR012677; IPR006515; IPR002004; IPR000504; Embryonic polyadenylate-binding protein (Embryonic poly(A)-binding protein) (ePABP) epabp Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39333_c0_g1_i1 P45878 FKBP2_MOUSE 1.00E-64 GO:0005528; GO:0005789; GO:0016020; GO:0003755; GO:0006457 FK506 binding; endoplasmic reticulum membrane; membrane; peptidyl-prolyl cis-trans isomerase activity; protein folding IPR023566; IPR001179; Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (13 kDa FK506-binding protein) (13 kDa FKBP) (FKBP-13) (FK506-binding protein 2) (FKBP-2) (Immunophilin FKBP13) (Rotamase) Fkbp2 Fkbp13 Mus musculus (Mouse) TR39334_c1_g1_i2 Q5ZJ01 F108B_CHICK 4.00E-139 GO:0005576; GO:0016787 extracellular region; hydrolase activity Alpha/beta hydrolase domain-containing protein 17B (EC 3.-.-.-) ABHD17B RCJMB04_22d6 Gallus gallus (Chicken) TR39335_c0_g1_i2 Q5REG1 SART3_PONAB 6.00E-143 GO:0003723; GO:0006396; GO:0005737; GO:0016607; GO:0000166 RNA binding; RNA processing; cytoplasm; nuclear speck; nucleotide binding IPR003107; IPR008669; IPR012677; IPR000504; Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) SART3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39335_c0_g1_i3 Q5REG1 SART3_PONAB 5.00E-143 GO:0003723; GO:0006396; GO:0005737; GO:0016607; GO:0000166 RNA binding; RNA processing; cytoplasm; nuclear speck; nucleotide binding IPR003107; IPR008669; IPR012677; IPR000504; Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) SART3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39337_c0_g1_i1 Q02508 HGV2_HALRO 7.00E-36 GO:0007275; GO:0005634 multicellular organismal development; nucleus IPR019544; IPR013026; IPR011990; IPR001440; IPR019734; Protein HGV2 HGV2 Halocynthia roretzi (Sea squirt) TR39337_c0_g1_i3 Q9I7K6 NASP_DROME 1.00E-05 IPR011990; Protein NASP homolog CG8223 Drosophila melanogaster (Fruit fly) TR39337_c0_g1_i5 P49321 NASP_HUMAN 1.00E-37 GO:0006260; GO:0051879; GO:0001824; GO:0007049; GO:0008283; GO:0005737; GO:0043486; GO:0005634; GO:0015031 DNA replication; Hsp90 protein binding; blastocyst development; cell cycle; cell proliferation; cytoplasm; histone exchange; nucleus; protein transport IPR019544; IPR013026; IPR011990; IPR001440; IPR019734; Nuclear autoantigenic sperm protein (NASP) NASP Homo sapiens (Human) TR39337_c0_g1_i8 P49321 NASP_HUMAN 4.00E-37 GO:0006260; GO:0051879; GO:0001824; GO:0007049; GO:0008283; GO:0005737; GO:0043486; GO:0005634; GO:0015031 DNA replication; Hsp90 protein binding; blastocyst development; cell cycle; cell proliferation; cytoplasm; histone exchange; nucleus; protein transport IPR019544; IPR013026; IPR011990; IPR001440; IPR019734; Nuclear autoantigenic sperm protein (NASP) NASP Homo sapiens (Human) TR39338_c1_g1_i3 Q6P642 DNJB6_XENTR 2.00E-19 GO:0005634; GO:0048471 nucleus; perinuclear region of cytoplasm IPR001623; IPR018253; DnaJ homolog subfamily B member 6 dnajb6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39338_c1_g1_i4 Q8MPX3 DNJ20_CAEEL 3.00E-09 GO:0006457 protein folding IPR002939; IPR001623; IPR018253; IPR008971; DnaJ homolog dnj-20 (DnaJ domain protein 20) dnj-20 T15H9.7/T15H9.1 Caenorhabditis elegans TR39338_c1_g1_i5 Q0II91 DJC21_BOVIN 1.00E-110 GO:0003676; GO:0008270 nucleic acid binding; zinc ion binding IPR001623; IPR018253; IPR007087; IPR015880; IPR022755; IPR003604; DnaJ homolog subfamily C member 21 DNAJC21 Bos taurus (Bovine) TR39338_c1_g1_i7 Q0II91 DJC21_BOVIN 1.00E-109 GO:0003676; GO:0008270 nucleic acid binding; zinc ion binding IPR001623; IPR018253; IPR007087; IPR015880; IPR022755; IPR003604; DnaJ homolog subfamily C member 21 DNAJC21 Bos taurus (Bovine) TR39339_c3_g3_i1 Q13263 TIF1B_HUMAN 3.00E-06 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR39344_c3_g1_i1 P57682 KLF3_HUMAN 1.00E-43 GO:0003677; GO:0046872; GO:0007275; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) KLF3 BKLF Homo sapiens (Human) TR39344_c3_g2_i2 P08153 SWI5_YEAST 6.00E-08 GO:0000980; GO:0005737; GO:0036033; GO:0046872; GO:0005634; GO:0031496; GO:0007074; GO:0000083; GO:0001133; GO:0006351 "RNA polymerase II distal enhancer sequence-specific DNA binding; cytoplasm; mediator complex binding; metal ion binding; nucleus; positive regulation of mating type switching; positive regulation of transcription on exit from mitosis, from RNA polymerase II promoter; regulation of transcription involved in G1/S transition of mitotic cell cycle; sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity; transcription, DNA-dependent" IPR017956; IPR007087; IPR015880; IPR013087; Transcriptional factor SWI5 SWI5 YDR146C YD8358.03C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39344_c3_g2_i3 Q9Y7G2 MIG1_CANAX 3.00E-13 GO:0003677; GO:0005975; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; carbohydrate metabolic process; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Regulatory protein MIG1 MIG1 Candida albicans (Yeast) TR39344_c3_g3_i1 O14335 SCR1_SCHPO 4.00E-13 GO:0000978; GO:0005829; GO:0046872; GO:0000122; GO:0005634; GO:0006351 "RNA polymerase II core promoter proximal region sequence-specific DNA binding; cytosol; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; DNA-binding protein scr1 scr1 SPBC1D7.02c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR39346_c1_g1_i1 B2RXR6 ANR44_MOUSE 1.00E-83 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) Ankrd44 Mus musculus (Mouse) TR39346_c1_g1_i2 Q12955 ANK3_HUMAN 0 GO:0043001; GO:0030315; GO:0007411; GO:0043194; GO:0007409; GO:0016323; GO:0045296; GO:0009986; GO:0043034; GO:0014704; GO:0044325; GO:0016328; GO:0005764; GO:0072660; GO:0071709; GO:0000281; GO:0033268; GO:0033270; GO:0010628; GO:1900827; GO:0045838; GO:2000651; GO:0010765; GO:0045211; GO:0030674; GO:0072661; GO:0019228; GO:0043266; GO:0007165; GO:0030507; GO:0014731; GO:0005200; GO:0050808 "Golgi to plasma membrane protein transport; T-tubule; axon guidance; axon initial segment; axonogenesis; basolateral plasma membrane; cadherin binding; cell surface; costamere; intercalated disc; ion channel binding; lateral plasma membrane; lysosome; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; node of Ranvier; paranode region of axon; positive regulation of gene expression; positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; postsynaptic membrane; protein binding, bridging; protein targeting to plasma membrane; regulation of action potential in neuron; regulation of potassium ion transport; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton; synapse organization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) TR39346_c1_g1_i3 Q01484 ANK2_HUMAN 0 GO:0051117; GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0007411; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005829; GO:0005887; GO:0014704; GO:0044325; GO:0086046; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307; GO:0070296 P11532-5; P62993 "ATPase binding; M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; axon guidance; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; cytosol; integral to plasma membrane; intercalated disc; ion channel binding; membrane depolarization involved in regulation of SA node cell action potential; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization; sarcoplasmic reticulum calcium ion transport" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) TR39346_c1_g1_i4 Q12955 ANK3_HUMAN 0 GO:0043001; GO:0030315; GO:0007411; GO:0043194; GO:0007409; GO:0016323; GO:0045296; GO:0009986; GO:0043034; GO:0014704; GO:0044325; GO:0016328; GO:0005764; GO:0072660; GO:0071709; GO:0000281; GO:0033268; GO:0033270; GO:0010628; GO:1900827; GO:0045838; GO:2000651; GO:0010765; GO:0045211; GO:0030674; GO:0072661; GO:0019228; GO:0043266; GO:0007165; GO:0030507; GO:0014731; GO:0005200; GO:0050808 "Golgi to plasma membrane protein transport; T-tubule; axon guidance; axon initial segment; axonogenesis; basolateral plasma membrane; cadherin binding; cell surface; costamere; intercalated disc; ion channel binding; lateral plasma membrane; lysosome; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; node of Ranvier; paranode region of axon; positive regulation of gene expression; positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; postsynaptic membrane; protein binding, bridging; protein targeting to plasma membrane; regulation of action potential in neuron; regulation of potassium ion transport; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton; synapse organization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) TR39346_c1_g1_i5 Q01484 ANK2_HUMAN 0 GO:0051117; GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0007411; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005829; GO:0005887; GO:0014704; GO:0044325; GO:0086046; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307; GO:0070296 P11532-5; P62993 "ATPase binding; M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; axon guidance; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; cytosol; integral to plasma membrane; intercalated disc; ion channel binding; membrane depolarization involved in regulation of SA node cell action potential; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization; sarcoplasmic reticulum calcium ion transport" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) TR39346_c1_g1_i6 Q6DD51 CSKI2_XENLA 3.00E-21 IPR002110; IPR020683; IPR027001; IPR001660; IPR013761; IPR021129; IPR011511; IPR001452; Caskin-2 caskin2 Xenopus laevis (African clawed frog) TR39346_c1_g1_i7 Q21920 ANKHM_CAEEL 7.00E-29 GO:0003723; GO:0005737 RNA binding; cytoplasm IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat and KH domain-containing protein R11A8.7 R11A8.7 Caenorhabditis elegans TR39348_c2_g1_i6 Q5ZJH7 CNPD1_CHICK 6.00E-63 GO:0016021; GO:0000079 integral to membrane; regulation of cyclin-dependent protein serine/threonine kinase activity IPR013922; Protein CNPPD1 CNPPD1 RCJMB04_3a20 Gallus gallus (Chicken) TR39349_c0_g1_i1 Q5RIW8 MED23_DANRE 0 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR021629; Mediator of RNA polymerase II transcription subunit 23 (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) med23 crsp3 si:ch211-272f15.2 zgc:91979 Danio rerio (Zebrafish) (Brachydanio rerio) TR39349_c0_g2_i1 Q60UZ5 MED23_CAEBR 1.00E-19 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR021629; Mediator of RNA polymerase II transcription subunit 23 (Mediator complex subunit 23) (Mediator complex subunit sur-2) sur-2 mdt-23 CBG19759 Caenorhabditis briggsae TR3935_c1_g1_i1 Q568W0 SELW_DANRE 1.00E-30 GO:0016209; GO:0045454; GO:0005737; GO:0008430 antioxidant activity; cell redox homeostasis; cytoplasm; selenium binding IPR011893; IPR012336; Selenoprotein W (SelW) sepw1 Danio rerio (Zebrafish) (Brachydanio rerio) TR39350_c5_g4_i3 Q55GU9 MSH6_DICDI 2.00E-67 GO:0005524; GO:0008094; GO:0032301; GO:0003684; GO:0000400; GO:0032137; GO:0043570; GO:0000710; GO:0045910; GO:0000228; GO:0007131; GO:0009411; GO:0032138 ATP binding; DNA-dependent ATPase activity; MutSalpha complex; damaged DNA binding; four-way junction DNA binding; guanine/thymine mispair binding; maintenance of DNA repeat elements; meiotic mismatch repair; negative regulation of DNA recombination; nuclear chromosome; reciprocal meiotic recombination; response to UV; single base insertion or deletion binding IPR017261; IPR015536; IPR007695; IPR000432; IPR007861; IPR007696; IPR016151; IPR007860; IPR027417; DNA mismatch repair protein Msh6 msh6 DDB_G0268614 Dictyostelium discoideum (Slime mold) TR39350_c5_g4_i4 Q9VUM0 MSH6_DROME 2.00E-89 GO:0005524; GO:0008094; GO:0032301; GO:0003684; GO:0000400; GO:0032137; GO:0008630; GO:0043570; GO:0000710; GO:0045910; GO:0000228; GO:0007131; GO:0009411; GO:0032138 ATP binding; DNA-dependent ATPase activity; MutSalpha complex; damaged DNA binding; four-way junction DNA binding; guanine/thymine mispair binding; intrinsic apoptotic signaling pathway in response to DNA damage; maintenance of DNA repeat elements; meiotic mismatch repair; negative regulation of DNA recombination; nuclear chromosome; reciprocal meiotic recombination; response to UV; single base insertion or deletion binding IPR017261; IPR015536; IPR007695; IPR000432; IPR007861; IPR007696; IPR016151; IPR007860; IPR027417; Probable DNA mismatch repair protein Msh6 Msh6 CG7003 Drosophila melanogaster (Fruit fly) TR39350_c5_g4_i5 P52701 MSH6_HUMAN 1.00E-117 GO:0005524; GO:0008094; GO:0032301; GO:0003682; GO:0003684; GO:0008340; GO:0032137; GO:0008630; GO:0045190; GO:0000710; GO:0035064; GO:0030983; GO:0045910; GO:0000790; GO:0000228; GO:0051096; GO:0007131; GO:0009411; GO:0016446 P43246 ATP binding; DNA-dependent ATPase activity; MutSalpha complex; chromatin binding; damaged DNA binding; determination of adult lifespan; guanine/thymine mispair binding; intrinsic apoptotic signaling pathway in response to DNA damage; isotype switching; meiotic mismatch repair; methylated histone residue binding; mismatched DNA binding; negative regulation of DNA recombination; nuclear chromatin; nuclear chromosome; positive regulation of helicase activity; reciprocal meiotic recombination; response to UV; somatic hypermutation of immunoglobulin genes IPR017261; IPR015536; IPR007695; IPR000432; IPR007861; IPR007696; IPR016151; IPR007860; IPR027417; IPR000313; DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS-alpha 160 kDa subunit) (p160) MSH6 GTBP Homo sapiens (Human) TR39352_c0_g1_i1 A7YW98 SYRC_BOVIN 0 GO:0005524; GO:0004814; GO:0006420; GO:0005739 ATP binding; arginine-tRNA ligase activity; arginyl-tRNA aminoacylation; mitochondrion IPR001412; IPR001278; IPR015945; IPR005148; IPR008909; IPR014729; IPR009080; "Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)" RARS Bos taurus (Bovine) TR39352_c0_g1_i3 Q6P1S4 SYRC_XENTR 0 GO:0005524; GO:0004814; GO:0006420; GO:0005737 ATP binding; arginine-tRNA ligase activity; arginyl-tRNA aminoacylation; cytoplasm IPR001412; IPR001278; IPR015945; IPR005148; IPR008909; IPR014729; IPR009080; "Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)" rars Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39353_c1_g1_i1 Q9VCA8 ANKHM_DROME 8.00E-22 GO:0003723; GO:0019730; GO:0051298; GO:0001751; GO:0005811; GO:0043066; GO:0046427; GO:0007169 RNA binding; antimicrobial humoral response; centrosome duplication; compound eye photoreceptor cell differentiation; lipid particle; negative regulation of apoptotic process; positive regulation of JAK-STAT cascade; transmembrane receptor protein tyrosine kinase signaling pathway IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) TR39353_c1_g1_i2 Q8Q0U0 Y045_METMA 3.00E-30 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR39353_c1_g1_i4 Q505D1 ANR28_MOUSE 2.00E-21 GO:0005654 nucleoplasm IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) Ankrd28 Mus musculus (Mouse) TR39354_c1_g2_i1 P46060 RAGP1_HUMAN 9.00E-113 GO:0005098; GO:0000777; GO:0005829; GO:0000278; GO:0046826; GO:0031965; GO:0005643; GO:0048471; GO:0007165; GO:0000922 P63165; P63279 Ran GTPase activator activity; condensed chromosome kinetochore; cytosol; mitotic cell cycle; negative regulation of protein export from nucleus; nuclear membrane; nuclear pore; perinuclear region of cytoplasm; signal transduction; spindle pole IPR009109; IPR027038; Ran GTPase-activating protein 1 (RanGAP1) RANGAP1 KIAA1835 SD Homo sapiens (Human) TR39354_c1_g2_i2 Q9VIW3 RAGP1_DROME 1.00E-80 GO:0005098; GO:0045132; GO:0022008; GO:0048471; GO:0006611; GO:0007165 Ran GTPase activator activity; meiotic chromosome segregation; neurogenesis; perinuclear region of cytoplasm; protein export from nucleus; signal transduction IPR009109; IPR027038; Ran GTPase-activating protein (RanGAP) (Protein segregation distorter) RanGap Sd CG9999 Drosophila melanogaster (Fruit fly) TR39354_c2_g1_i1 Q2T9J0 TYSD1_HUMAN 1.00E-31 GO:0005777; GO:0051260; GO:0016485; GO:0006508; GO:0031998; GO:0004252 peroxisome; protein homooligomerization; protein processing; proteolysis; regulation of fatty acid beta-oxidation; serine-type endopeptidase activity IPR017345; IPR001254; IPR009003; "Peroxisomal leader peptide-processing protease (EC 3.4.21.-) (Trypsin domain-containing protein 1) [Cleaved into: Peroxisomal leader peptide-processing protease, 15 kDa form; Peroxisomal leader peptide-processing protease, 45 kDa form]" TYSND1 Homo sapiens (Human) TR39355_c2_g1_i5 Q26486 FKBP4_SPOFR 4.00E-33 GO:0003677; GO:0005528; GO:0000412; GO:0005730; GO:0003755; GO:0006457 DNA binding; FK506 binding; histone peptidyl-prolyl isomerization; nucleolus; peptidyl-prolyl cis-trans isomerase activity; protein folding IPR026257; IPR023566; IPR001179; 46 kDa FK506-binding nuclear protein (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) FKBP46 Spodoptera frugiperda (Fall armyworm) TR39356_c0_g1_i1 Q8WZ42 TITIN_HUMAN 3.00E-75 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR39356_c0_g1_i2 Q9I7U4 TITIN_DROME 2.00E-53 GO:0030018; GO:0003779; GO:0051301; GO:0000794; GO:0040011; GO:0007498; GO:0005875; GO:0007076; GO:0016203; GO:0007520; GO:0035206; GO:0045214; GO:0007062; GO:0007519; GO:0007525; GO:0008307; GO:0007522 Z disc; actin binding; cell division; condensed nuclear chromosome; locomotion; mesoderm development; microtubule associated complex; mitotic chromosome condensation; muscle attachment; myoblast fusion; regulation of hemocyte proliferation; sarcomere organization; sister chromatid cohesion; skeletal muscle tissue development; somatic muscle development; structural constituent of muscle; visceral muscle development IPR010939; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR001452; Titin (D-Titin) (Kettin) sls titin CG1915 Drosophila melanogaster (Fruit fly) TR39356_c0_g1_i3 Q15746 MYLK_HUMAN 8.00E-25 GO:0005524; GO:0060414; GO:0032060; GO:0071476; GO:0032154; GO:0005829; GO:0030027; GO:0046872; GO:0004687; GO:0005886; GO:0051928; GO:0030335; GO:0090303; GO:0001725; GO:0014820 P16333 ATP binding; aorta smooth muscle tissue morphogenesis; bleb assembly; cellular hypotonic response; cleavage furrow; cytosol; lamellipodium; metal ion binding; myosin light chain kinase activity; plasma membrane; positive regulation of calcium ion transport; positive regulation of cell migration; positive regulation of wound healing; stress fiber; tonic smooth muscle contraction IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR020675; IPR000719; IPR017441; IPR002290; IPR008271; "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]" MYLK MLCK MLCK1 MYLK1 Homo sapiens (Human) TR39357_c0_g1_i1 Q0P4F7 ACSF2_DANRE 0 GO:0005524; GO:0006631; GO:0016874; GO:0005739 ATP binding; fatty acid metabolic process; ligase activity; mitochondrion IPR025110; IPR020845; IPR000873; "Acyl-CoA synthetase family member 2, mitochondrial (EC 6.2.1.-)" acsf2 zgc:152887 Danio rerio (Zebrafish) (Brachydanio rerio) TR39357_c0_g1_i2 Q86V21 AACS_HUMAN 2.00E-11 GO:0005524; GO:0030729; GO:0060612; GO:0047760; GO:0071397; GO:0071333; GO:0071394; GO:0005829; GO:0006631; GO:0001889; GO:0032024; GO:0042493; GO:0045471; GO:0007584; GO:0034201; GO:0014074; GO:0042594; GO:0050872 ATP binding; acetoacetate-CoA ligase activity; adipose tissue development; butyrate-CoA ligase activity; cellular response to cholesterol; cellular response to glucose stimulus; cellular response to testosterone stimulus; cytosol; fatty acid metabolic process; liver development; positive regulation of insulin secretion; response to drug; response to ethanol; response to nutrient; response to oleic acid; response to purine-containing compound; response to starvation; white fat cell differentiation IPR005914; IPR020845; IPR000873; Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog) AACS ACSF1 Homo sapiens (Human) TR39357_c0_g1_i3 Q0P4F7 ACSF2_DANRE 2.00E-124 GO:0005524; GO:0006631; GO:0016874; GO:0005739 ATP binding; fatty acid metabolic process; ligase activity; mitochondrion IPR025110; IPR020845; IPR000873; "Acyl-CoA synthetase family member 2, mitochondrial (EC 6.2.1.-)" acsf2 zgc:152887 Danio rerio (Zebrafish) (Brachydanio rerio) TR39359_c0_g2_i1 P34121 COAA_DICDI 4.00E-13 GO:0015629; GO:0051015; GO:0045335; GO:0030833; GO:0009617 actin cytoskeleton; actin filament binding; phagocytic vesicle; regulation of actin filament polymerization; response to bacterium IPR002108; Coactosin (Cyclic AMP-regulated protein p16) (Cytoskeletal protein p17) coaA p17 DDB_G0293898 Dictyostelium discoideum (Slime mold) TR3936_c0_g1_i1 Q9TSV4 TCF19_PIG 6.00E-07 GO:0005634; GO:0006355; GO:0006351; GO:0008270 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR000253; IPR008984; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Transcription factor 19 (TCF-19) (Transcription factor SC1) TCF19 SC1 Sus scrofa (Pig) TR39360_c0_g2_i1 O44252 ROST_DROME 8.00E-07 GO:0016021; GO:0016020; GO:0007520; GO:0007519 integral to membrane; membrane; myoblast fusion; skeletal muscle tissue development IPR006838; Protein rolling stone rost CG9552 Drosophila melanogaster (Fruit fly) TR39361_c7_g1_i3 Q14BP6 YV012_MOUSE 3.00E-08 IPR001611; Leucine-rich repeat-containing protein LOC400891 homolog Mus musculus (Mouse) TR39361_c7_g1_i4 C3VPR6 NLRC5_MOUSE 2.00E-11 GO:0005524; GO:0000979; GO:0005829; GO:0051607; GO:0045087; GO:0032088; GO:0060339; GO:0005634; GO:0045345; GO:0060335; GO:0045944; GO:0060340; GO:0043549 ATP binding; RNA polymerase II core promoter sequence-specific DNA binding; cytosol; defense response to virus; innate immune response; negative regulation of NF-kappaB transcription factor activity; negative regulation of type I interferon-mediated signaling pathway; nucleus; positive regulation of MHC class I biosynthetic process; positive regulation of interferon-gamma-mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of type I interferon-mediated signaling pathway; regulation of kinase activity IPR000767; IPR007111; IPR027417; Protein NLRC5 Nlrc5 Mus musculus (Mouse) TR39362_c0_g1_i2 Q6NWG4 ANM6_DANRE 2.00E-56 GO:0006281; GO:0042393; GO:0070612; GO:0070611; GO:0044020; GO:0045892; GO:0005634; GO:0035242; GO:0035241; GO:0006351 "DNA repair; histone binding; histone methyltransferase activity (H2A-R3 specific); histone methyltransferase activity (H3-R2 specific); histone methyltransferase activity (H4-R3 specific); negative regulation of transcription, DNA-dependent; nucleus; protein-arginine omega-N asymmetric methyltransferase activity; protein-arginine omega-N monomethyltransferase activity; transcription, DNA-dependent" IPR025799; IPR026132; Protein arginine N-methyltransferase 6 (EC 2.1.1.-) (Histone-arginine N-methyltransferase PRMT6) (EC 2.1.1.125) prmt6 Danio rerio (Zebrafish) (Brachydanio rerio) TR39362_c0_g1_i3 O70467 ANM3_RAT 2.00E-173 GO:0005737; GO:0005829; GO:0046872; GO:0072341; GO:0035242; GO:0005840 cytoplasm; cytosol; metal ion binding; modified amino acid binding; protein-arginine omega-N asymmetric methyltransferase activity; ribosome IPR025799; IPR010456; IPR015880; Protein arginine N-methyltransferase 3 (EC 2.1.1.-) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3) Prmt3 Hrmt1l3 Rattus norvegicus (Rat) TR39363_c1_g1_i1 P89116 CASP1_SPOFR 2.00E-30 GO:0006915; GO:0004197; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-1 (EC 3.4.22.-) [Cleaved into: Caspase-1 subunit p19/18; Caspase-1 subunit p12] Spodoptera frugiperda (Fall armyworm) TR39363_c3_g1_i1 Q8IWA0 WDR75_HUMAN 8.00E-153 GO:0005634 nucleus IPR011047; IPR015943; IPR001680; IPR017986; WD repeat-containing protein 75 WDR75 UTP17 Homo sapiens (Human) TR39363_c3_g1_i2 Q8IWA0 WDR75_HUMAN 9.00E-42 GO:0005634 nucleus IPR011047; IPR015943; IPR001680; IPR017986; WD repeat-containing protein 75 WDR75 UTP17 Homo sapiens (Human) TR39364_c3_g1_i1 Q6P9N1 HYCCI_MOUSE 7.00E-65 GO:0005737; GO:0005886 cytoplasm; plasma membrane IPR018619; Hyccin (Down-regulated by CTNNB1 protein A) (Protein FAM126A) Fam126a Drctnnb1a Mus musculus (Mouse) TR39364_c4_g2_i1 Q91WT9 CBS_MOUSE 0 GO:0019448; GO:0006565; GO:0030554; GO:0001974; GO:0060351; GO:0021587; GO:0004122; GO:0019344; GO:0006535; GO:0019343; GO:0005829; GO:0001958; GO:0020037; GO:0043418; GO:0050667; GO:0070814; GO:0060135; GO:0046872; GO:0072341; GO:0005634; GO:0030170; GO:0043506; GO:0050880; GO:0030823; GO:0051593; GO:0006801 L-cysteine catabolic process; L-serine catabolic process; adenyl nucleotide binding; blood vessel remodeling; cartilage development involved in endochondral bone morphogenesis; cerebellum morphogenesis; cystathionine beta-synthase activity; cysteine biosynthetic process; cysteine biosynthetic process from serine; cysteine biosynthetic process via cystathionine; cytosol; endochondral ossification; heme binding; homocysteine catabolic process; homocysteine metabolic process; hydrogen sulfide biosynthetic process; maternal process involved in female pregnancy; metal ion binding; modified amino acid binding; nucleus; pyridoxal phosphate binding; regulation of JUN kinase activity; regulation of blood vessel size; regulation of cGMP metabolic process; response to folic acid; superoxide metabolic process IPR000644; IPR001216; IPR005857; IPR001926; Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2. Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) Cbs Mus musculus (Mouse) TR39364_c4_g2_i2 P32582 CBS_YEAST 2.00E-113 GO:0030554; GO:0004122; GO:0006535; GO:0019343; GO:0005737; GO:0070814; GO:0019346; GO:0007089 adenyl nucleotide binding; cystathionine beta-synthase activity; cysteine biosynthetic process from serine; cysteine biosynthetic process via cystathionine; cytoplasm; hydrogen sulfide biosynthetic process; transsulfuration; traversing start control point of mitotic cell cycle IPR000644; IPR001216; IPR005857; IPR001926; Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2. Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) (Sulfur transfer protein 4) CYS4 STR4 YGR155W G6667 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39364_c4_g2_i3 Q91WT9 CBS_MOUSE 0 GO:0019448; GO:0006565; GO:0030554; GO:0001974; GO:0060351; GO:0021587; GO:0004122; GO:0019344; GO:0006535; GO:0019343; GO:0005829; GO:0001958; GO:0020037; GO:0043418; GO:0050667; GO:0070814; GO:0060135; GO:0046872; GO:0072341; GO:0005634; GO:0030170; GO:0043506; GO:0050880; GO:0030823; GO:0051593; GO:0006801 L-cysteine catabolic process; L-serine catabolic process; adenyl nucleotide binding; blood vessel remodeling; cartilage development involved in endochondral bone morphogenesis; cerebellum morphogenesis; cystathionine beta-synthase activity; cysteine biosynthetic process; cysteine biosynthetic process from serine; cysteine biosynthetic process via cystathionine; cytosol; endochondral ossification; heme binding; homocysteine catabolic process; homocysteine metabolic process; hydrogen sulfide biosynthetic process; maternal process involved in female pregnancy; metal ion binding; modified amino acid binding; nucleus; pyridoxal phosphate binding; regulation of JUN kinase activity; regulation of blood vessel size; regulation of cGMP metabolic process; response to folic acid; superoxide metabolic process IPR000644; IPR001216; IPR005857; IPR001926; Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2. Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) Cbs Mus musculus (Mouse) TR39365_c0_g1_i1 Q03701 CEBPZ_HUMAN 0 GO:0003677; GO:0005634; GO:0006355; GO:0006366 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter" IPR016024; IPR005612; CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor) CEBPZ CBF2 Homo sapiens (Human) TR39365_c0_g1_i2 Q03701 CEBPZ_HUMAN 0 GO:0003677; GO:0005634; GO:0006355; GO:0006366 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter" IPR016024; IPR005612; CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor) CEBPZ CBF2 Homo sapiens (Human) TR39366_c3_g1_i1 Q62849 PCSK7_RAT 8.00E-30 GO:0005794; GO:0030173; GO:0006508; GO:0004252 Golgi apparatus; integral to Golgi membrane; proteolysis; serine-type endopeptidase activity IPR008979; IPR000209; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 7 (EC 3.4.21.-) (Prohormone convertase 7) (Proprotein convertase 7) (PC7) (rPC7) (Subtilisin/kexin-like protease PC7) Pcsk7 Pc7 Rattus norvegicus (Rat) TR39367_c1_g1_i2 Q6NRT5 CSN1_XENLA 0 GO:0008180; GO:0005737 COP9 signalosome; cytoplasm IPR019585; IPR000717; IPR011991; COP9 signalosome complex subunit 1 (Signalosome subunit 1) csn1 Xenopus laevis (African clawed frog) TR39367_c1_g1_i3 Q5BD89 CSN1_EMENI 1.00E-73 GO:0008180; GO:0070791; GO:0005737 COP9 signalosome; cleistothecium development; cytoplasm IPR019585; IPR000717; IPR011991; COP9 signalosome complex subunit 1 (CSN complex subunit 1) csnA csn1 AN1491 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR39368_c6_g1_i1 Q61704 ITIH3_MOUSE 2.00E-145 GO:0005576; GO:0030212; GO:0004867 extracellular region; hyaluronan metabolic process; serine-type endopeptidase inhibitor activity IPR010600; IPR013694; IPR002035; Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) Itih3 Mus musculus (Mouse) TR39368_c6_g1_i2 Q61704 ITIH3_MOUSE 2.00E-144 GO:0005576; GO:0030212; GO:0004867 extracellular region; hyaluronan metabolic process; serine-type endopeptidase inhibitor activity IPR010600; IPR013694; IPR002035; Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) Itih3 Mus musculus (Mouse) TR39369_c0_g2_i1 Q8IWL3 HSC20_HUMAN 1.00E-42 GO:0016226; GO:0046872; GO:0005739; GO:0006457; GO:0051259 iron-sulfur cluster assembly; metal ion binding; mitochondrion; protein folding; protein oligomerization IPR001623; IPR004640; IPR009073; Cofactor biosynthesis; iron-sulfur cluster biosynthesis. "Iron-sulfur cluster co-chaperone protein HscB, mitochondrial (DnaJ homolog subfamily C member 20) (Hsc20)" HSCB DNAJC20 HSC20 Homo sapiens (Human) TR39369_c0_g2_i4 A3QFD2 HSCB_SHELP 3.00E-21 GO:0006457; GO:0051259 protein folding; protein oligomerization IPR001623; IPR004640; IPR009073; Co-chaperone protein HscB homolog hscB Shew_2314 Shewanella loihica (strain ATCC BAA-1088 / PV-4) TR39369_c0_g2_i5 Q8IWL3 HSC20_HUMAN 9.00E-43 GO:0016226; GO:0046872; GO:0005739; GO:0006457; GO:0051259 iron-sulfur cluster assembly; metal ion binding; mitochondrion; protein folding; protein oligomerization IPR001623; IPR004640; IPR009073; Cofactor biosynthesis; iron-sulfur cluster biosynthesis. "Iron-sulfur cluster co-chaperone protein HscB, mitochondrial (DnaJ homolog subfamily C member 20) (Hsc20)" HSCB DNAJC20 HSC20 Homo sapiens (Human) TR39372_c0_g1_i3 O95295 SNAPN_HUMAN 5.00E-33 GO:0031083; GO:0005794; GO:0000139; GO:0000149; GO:0008089; GO:0048490; GO:0030054; GO:0006886; GO:0032438; GO:0019048; GO:0043005; GO:0031175; GO:0005730; GO:0048471; GO:0008021; GO:0016079; GO:0031629; GO:0016188; GO:0030672; GO:0072553 Q6QNY1; Q9UL45; Q96EV8; O75923; Q15849-1; Q62668-1; P11277 BLOC-1 complex; Golgi apparatus; Golgi membrane; SNARE binding; anterograde axon cargo transport; anterograde synaptic vesicle transport; cell junction; intracellular protein transport; melanosome organization; modulation by virus of host morphology or physiology; neuron projection; neuron projection development; nucleolus; perinuclear region of cytoplasm; synaptic vesicle; synaptic vesicle exocytosis; synaptic vesicle fusion to presynaptic membrane; synaptic vesicle maturation; synaptic vesicle membrane; terminal button organization IPR017246; IPR028119; SNARE-associated protein Snapin (Biogenesis of lysosome-related organelles complex 1 subunit 7) (BLOC-1 subunit 7) (Synaptosomal-associated protein 25-binding protein) (SNAP-associated protein) SNAPIN BLOC1S7 SNAP25BP SNAPAP Homo sapiens (Human) TR39373_c0_g1_i2 Q0MQI9 NDUV2_PANTR 3.00E-111 GO:0051537; GO:0008137; GO:0046872; GO:0006120; GO:0005747 "2 iron, 2 sulfur cluster binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I" IPR002023; IPR012336; "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase 24 kDa subunit)" NDUFV2 Pan troglodytes (Chimpanzee) TR39374_c0_g2_i2 Q6AXQ5 PDE12_RAT 2.00E-122 GO:0016787 hydrolase activity IPR005135; "2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4)" Pde12 Rattus norvegicus (Rat) TR39374_c0_g2_i3 Q8W0Z9 CCR4A_ARATH 2.00E-28 GO:0003723; GO:0005829; GO:0046872; GO:0090305; GO:0005634; GO:0004535; GO:0006355; GO:0006351 "RNA binding; cytosol; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleus; poly(A)-specific ribonuclease activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR005135; Carbon catabolite repressor protein 4 homolog 1 (CCR4 homolog 1) (EC 3.1.13.4) CCR4-1 At3g58560 F14P22.150 Arabidopsis thaliana (Mouse-ear cress) TR39375_c2_g1_i1 Q5ZLY0 PHAX_CHICK 7.00E-24 GO:0003723; GO:0005737; GO:0005634; GO:0015031 RNA binding; cytoplasm; nucleus; protein transport IPR019385; Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) PHAX RNUXA RCJMB04_4h18 Gallus gallus (Chicken) TR39375_c2_g3_i2 Q5ZLY0 PHAX_CHICK 2.00E-23 GO:0003723; GO:0005737; GO:0005634; GO:0015031 RNA binding; cytoplasm; nucleus; protein transport IPR019385; Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) PHAX RNUXA RCJMB04_4h18 Gallus gallus (Chicken) TR39377_c7_g1_i1 Q95M72 BIRC8_PANTR 1.00E-12 GO:0006915; GO:0005737; GO:0008270 apoptotic process; cytoplasm; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis-like protein 2) (IAP-like protein 2) (ILP-2) BIRC8 ILP2 Pan troglodytes (Chimpanzee) TR39377_c7_g1_i2 Q6NTT6 MUL1_XENLA 7.00E-06 GO:0006919; GO:0042802; GO:0031307; GO:0000266; GO:0051646; GO:0030308; GO:0005777; GO:0043123; GO:0004871; GO:0004842; GO:0008270 activation of cysteine-type endopeptidase activity involved in apoptotic process; identical protein binding; integral to mitochondrial outer membrane; mitochondrial fission; mitochondrion localization; negative regulation of cell growth; peroxisome; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR022170; IPR001841; IPR013083; Protein modification; protein ubiquitination. Mitochondrial ubiquitin ligase activator of nfkb 1 (EC 6.3.2.-) (E3 ubiquitin-protein ligase mul1) mul1 Xenopus laevis (African clawed frog) TR39377_c7_g1_i3 Q13489 BIRC3_HUMAN 6.00E-17 GO:0038061; GO:0035666; GO:0006915; GO:0007166; GO:0005829; GO:0045087; GO:0070266; GO:0043066; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0043123; GO:0039535; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0034138; GO:0034142; GO:0004842; GO:0008270 Q13546; O43353; Q9Y572; P57078; Q12933 NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; apoptotic process; cell surface receptor signaling pathway; cytosol; innate immune response; necroptosis; negative regulation of apoptotic process; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of RIG-I signaling pathway; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Apoptosis inhibitor 2) (API2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (IAP-1) (hIAP-1) (hIAP1) (RING finger protein 49) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 IAP1 MIHC RNF49 Homo sapiens (Human) TR39378_c0_g1_i3 Q9EP53 TSC1_MOUSE 1.00E-66 GO:0030695; GO:0033596; GO:0005884; GO:0032862; GO:0055007; GO:0005938; GO:0030030; GO:0007160; GO:0021987; GO:0005737; GO:0030426; GO:0021766; GO:0043231; GO:0001822; GO:0030027; GO:0016020; GO:0042552; GO:0032007; GO:0008285; GO:0045792; GO:0017148; GO:0001843; GO:0051894; GO:0006813; GO:0051291; GO:0050821; GO:0006407; GO:0043666; GO:0045859; GO:0051492; GO:0032868; GO:0050808 Q61037 GTPase regulator activity; TSC1-TSC2 complex; actin filament; activation of Rho GTPase activity; cardiac muscle cell differentiation; cell cortex; cell projection organization; cell-matrix adhesion; cerebral cortex development; cytoplasm; growth cone; hippocampus development; intracellular membrane-bounded organelle; kidney development; lamellipodium; membrane; myelination; negative regulation of TOR signaling cascade; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of translation; neural tube closure; positive regulation of focal adhesion assembly; potassium ion transport; protein heterooligomerization; protein stabilization; rRNA export from nucleus; regulation of phosphoprotein phosphatase activity; regulation of protein kinase activity; regulation of stress fiber assembly; response to insulin stimulus; synapse organization IPR016024; IPR007483; Hamartin (Tuberous sclerosis 1 protein homolog) Tsc1 Kiaa0243 Mus musculus (Mouse) TR39378_c0_g1_i4 Q9EP53 TSC1_MOUSE 2.00E-66 GO:0030695; GO:0033596; GO:0005884; GO:0032862; GO:0055007; GO:0005938; GO:0030030; GO:0007160; GO:0021987; GO:0005737; GO:0030426; GO:0021766; GO:0043231; GO:0001822; GO:0030027; GO:0016020; GO:0042552; GO:0032007; GO:0008285; GO:0045792; GO:0017148; GO:0001843; GO:0051894; GO:0006813; GO:0051291; GO:0050821; GO:0006407; GO:0043666; GO:0045859; GO:0051492; GO:0032868; GO:0050808 Q61037 GTPase regulator activity; TSC1-TSC2 complex; actin filament; activation of Rho GTPase activity; cardiac muscle cell differentiation; cell cortex; cell projection organization; cell-matrix adhesion; cerebral cortex development; cytoplasm; growth cone; hippocampus development; intracellular membrane-bounded organelle; kidney development; lamellipodium; membrane; myelination; negative regulation of TOR signaling cascade; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of translation; neural tube closure; positive regulation of focal adhesion assembly; potassium ion transport; protein heterooligomerization; protein stabilization; rRNA export from nucleus; regulation of phosphoprotein phosphatase activity; regulation of protein kinase activity; regulation of stress fiber assembly; response to insulin stimulus; synapse organization IPR016024; IPR007483; Hamartin (Tuberous sclerosis 1 protein homolog) Tsc1 Kiaa0243 Mus musculus (Mouse) TR39378_c0_g2_i3 Q92574 TSC1_HUMAN 1.00E-08 GO:0030695; GO:0033596; GO:0032862; GO:0055007; GO:0005938; GO:0007050; GO:0030030; GO:0007160; GO:0021987; GO:0030426; GO:0021766; GO:0008286; GO:0043231; GO:0001822; GO:0030027; GO:0016020; GO:0042552; GO:0032007; GO:0008285; GO:0045792; GO:0017148; GO:0001843; GO:0051894; GO:0006813; GO:0051291; GO:0050821; GO:0006407; GO:0043666; GO:0045859; GO:0051492; GO:0050808 O14920; Q16539; Q00994; P49815 GTPase regulator activity; TSC1-TSC2 complex; activation of Rho GTPase activity; cardiac muscle cell differentiation; cell cortex; cell cycle arrest; cell projection organization; cell-matrix adhesion; cerebral cortex development; growth cone; hippocampus development; insulin receptor signaling pathway; intracellular membrane-bounded organelle; kidney development; lamellipodium; membrane; myelination; negative regulation of TOR signaling cascade; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of translation; neural tube closure; positive regulation of focal adhesion assembly; potassium ion transport; protein heterooligomerization; protein stabilization; rRNA export from nucleus; regulation of phosphoprotein phosphatase activity; regulation of protein kinase activity; regulation of stress fiber assembly; synapse organization IPR007483; Hamartin (Tuberous sclerosis 1 protein) TSC1 KIAA0243 TSC Homo sapiens (Human) TR39381_c0_g1_i1 Q5XWD5 IF_CANFA 3.00E-15 GO:0031419; GO:0009235; GO:0015889; GO:0006824; GO:0005576 cobalamin binding; cobalamin metabolic process; cobalamin transport; cobalt ion transport; extracellular region IPR002157; IPR027954; Gastric intrinsic factor (Intrinsic factor) (IF) (INF) (Pancreatic intrinsic factor) GIF Canis familiaris (Dog) (Canis lupus familiaris) TR39381_c0_g1_i2 Q9W4K2 Y3556_DROME 5.00E-13 GO:0031419; GO:0015889; GO:0005576 cobalamin binding; cobalamin transport; extracellular region IPR002157; IPR019554; IPR008930; Uncharacterized protein CG3556 CG3556 Drosophila melanogaster (Fruit fly) TR39383_c0_g1_i2 P48067 SC6A9_HUMAN 2.00E-127 GO:0015375; GO:0005887; GO:0005328 glycine:sodium symporter activity; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) SLC6A9 Homo sapiens (Human) TR39383_c1_g1_i1 Q9Y345 SC6A5_HUMAN 5.00E-155 GO:0015375; GO:0016021; GO:0005328; GO:0005886; GO:0007268 glycine:sodium symporter activity; integral to membrane; neurotransmitter:sodium symporter activity; plasma membrane; synaptic transmission IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) TR39385_c0_g2_i1 Q9Z335 SBK1_RAT 1.00E-75 GO:0005524; GO:0007420; GO:0005737; GO:0018105; GO:0018107; GO:0004674 ATP binding; brain development; cytoplasm; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; protein serine/threonine kinase activity IPR011009; IPR000719; IPR002290; IPR008271; IPR016234; Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1) Sbk1 Sbk Rattus norvegicus (Rat) TR39386_c0_g1_i2 Q6AXT0 RM37_RAT 2.00E-37 GO:0005739; GO:0005840; GO:0003735; GO:0006412 mitochondrion; ribosome; structural constituent of ribosome; translation IPR010793; "39S ribosomal protein L37, mitochondrial (L37mt) (MRP-L37)" Mrpl37 Rattus norvegicus (Rat) TR39388_c0_g2_i2 Q7QB13 CCNC_ANOGA 3.00E-06 GO:0016591; GO:0000079; GO:0006355; GO:0006351 "DNA-directed RNA polymerase II, holoenzyme; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR013763; IPR015429; IPR006671; IPR023598; Cyclin-C CycC AGAP004240 Anopheles gambiae (African malaria mosquito) TR39388_c0_g2_i4 Q52KE7 CCNL1_MOUSE 2.00E-77 GO:0006396; GO:0005737; GO:0016607; GO:0000079; GO:0006355; GO:0008023; GO:0006351 "RNA processing; cytoplasm; nuclear speck; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription, DNA-dependent; transcription elongation factor complex; transcription, DNA-dependent" IPR013763; IPR015429; IPR017060; IPR015431; IPR006671; Cyclin-L1 (Cyclin-L) (Cyclin Ania-6a) Ccnl1 Ania6a Ccn1 Mus musculus (Mouse) TR39388_c0_g2_i6 Q52KE7 CCNL1_MOUSE 2.00E-77 GO:0006396; GO:0005737; GO:0016607; GO:0000079; GO:0006355; GO:0008023; GO:0006351 "RNA processing; cytoplasm; nuclear speck; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription, DNA-dependent; transcription elongation factor complex; transcription, DNA-dependent" IPR013763; IPR015429; IPR017060; IPR015431; IPR006671; Cyclin-L1 (Cyclin-L) (Cyclin Ania-6a) Ccnl1 Ania6a Ccn1 Mus musculus (Mouse) TR39389_c0_g1_i1 Q63ZI0 KCNK9_XENLA 3.00E-100 GO:0016021; GO:0005267; GO:0005244 integral to membrane; potassium channel activity; voltage-gated ion channel activity IPR003280; IPR013099; IPR003092; IPR005407; Potassium channel subfamily K member 9 kcnk9 Xenopus laevis (African clawed frog) TR39389_c0_g1_i3 Q63ZI0 KCNK9_XENLA 3.00E-100 GO:0016021; GO:0005267; GO:0005244 integral to membrane; potassium channel activity; voltage-gated ion channel activity IPR003280; IPR013099; IPR003092; IPR005407; Potassium channel subfamily K member 9 kcnk9 Xenopus laevis (African clawed frog) TR39389_c0_g1_i4 Q9NYG8 KCNK4_HUMAN 3.00E-20 GO:0016021; GO:0005886; GO:0005267; GO:0007268; GO:0005244 integral to membrane; plasma membrane; potassium channel activity; synaptic transmission; voltage-gated ion channel activity IPR003280; IPR013099; IPR008074; Potassium channel subfamily K member 4 (TWIK-related arachidonic acid-stimulated potassium channel protein) (TRAAK) (Two pore potassium channel KT4.1) (Two pore K(+) channel KT4.1) KCNK4 TRAAK Homo sapiens (Human) TR39391_c1_g1_i1 Q8T158 FAM91_DICDI 4.00E-66 IPR028093; IPR028097; IPR028091; Protein FAM91 homolog fam91 DDB_G0274247 Dictyostelium discoideum (Slime mold) TR39391_c2_g1_i3 Q3UVG3 F91A1_MOUSE 2.00E-145 IPR028093; IPR028097; IPR028091; Protein FAM91A1 Fam91a1 D15Ertd621e Kiaa0493 Mus musculus (Mouse) TR39391_c2_g1_i4 Q3UVG3 F91A1_MOUSE 2.00E-140 IPR028093; IPR028097; IPR028091; Protein FAM91A1 Fam91a1 D15Ertd621e Kiaa0493 Mus musculus (Mouse) TR39391_c2_g1_i5 Q8T158 FAM91_DICDI 8.00E-61 IPR028093; IPR028097; IPR028091; Protein FAM91 homolog fam91 DDB_G0274247 Dictyostelium discoideum (Slime mold) TR39392_c0_g1_i2 O50655 XERD_SELRU 2.00E-06 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR39394_c3_g2_i1 Q7JQD3 GELS1_LUMTE 8.00E-123 GO:0003779; GO:0051693; GO:0030043; GO:0030041; GO:0051014; GO:0045010; GO:0005509; GO:0005737; GO:0005856; GO:0007275 actin binding; actin filament capping; actin filament fragmentation; actin filament polymerization; actin filament severing; actin nucleation; calcium ion binding; cytoplasm; cytoskeleton; multicellular organismal development IPR007123; IPR007122; Gelsolin-like protein 1 (Actin-modulator) (EWAM) (EWAM-P1) AM Lumbricus terrestris (Common earthworm) TR39394_c3_g2_i2 Q07171 GELS_DROME 1.00E-49 GO:0003779; GO:0005884; GO:0030041; GO:0005829; GO:0005576; GO:0046872; GO:0006909 actin binding; actin filament; actin filament polymerization; cytosol; extracellular region; metal ion binding; phagocytosis IPR007123; IPR007122; Gelsolin Gel CG1106 Drosophila melanogaster (Fruit fly) TR39394_c3_g2_i3 Q24800 SEVE_ECHGR 4.00E-98 GO:0051693 actin filament capping IPR007123; IPR007122; Severin AG8 Echinococcus granulosus TR39394_c3_g2_i4 Q8MPM1 GELS2_LUMTE 4.00E-124 GO:0051693; GO:0005737; GO:0005856 actin filament capping; cytoplasm; cytoskeleton IPR007123; IPR007122; Gelsolin-like protein 2 (Actin-modulator) (EWAM-P2) gelsolin Lumbricus terrestris (Common earthworm) TR39396_c0_g1_i1 Q6DDX8 CEP76_XENLA 0 GO:0005814; GO:0046599 centriole; regulation of centriole replication Centrosomal protein of 76 kDa (Cep76) cep76 Xenopus laevis (African clawed frog) TR39396_c0_g3_i4 Q28DH9 CEP76_XENTR 1.00E-45 GO:0005814; GO:0046599 centriole; regulation of centriole replication Centrosomal protein of 76 kDa (Cep76) cep76 TEgg032c01.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39397_c1_g1_i1 Q5BJJ7 BCCIP_DANRE 6.00E-48 GO:0006281; GO:0007049; GO:0005634 DNA repair; cell cycle; nucleus IPR025602; Protein BCCIP homolog bccip zgc:110272 Danio rerio (Zebrafish) (Brachydanio rerio) TR39397_c2_g3_i2 P60905 DNJC5_RAT 1.00E-43 GO:0042470; GO:0005886; GO:0007268 melanosome; plasma membrane; synaptic transmission IPR001623; IPR018253; DnaJ homolog subfamily C member 5 (Cysteine string protein) (CSP) Dnajc5 Csp Rattus norvegicus (Rat) TR39397_c2_g3_i6 P60905 DNJC5_RAT 9.00E-44 GO:0042470; GO:0005886; GO:0007268 melanosome; plasma membrane; synaptic transmission IPR001623; IPR018253; DnaJ homolog subfamily C member 5 (Cysteine string protein) (CSP) Dnajc5 Csp Rattus norvegicus (Rat) TR39398_c0_g1_i1 Q8BRB7 KAT6B_MOUSE 1.00E-128 GO:0003677; GO:0070776; GO:0043966; GO:0004402; GO:0045892; GO:0000786; GO:0006334; GO:0045893; GO:0008134; GO:0006351; GO:0008270 "DNA binding; MOZ/MORF histone acetyltransferase complex; histone H3 acetylation; histone acetyltransferase activity; negative regulation of transcription, DNA-dependent; nucleosome; nucleosome assembly; positive regulation of transcription, DNA-dependent; transcription factor binding; transcription, DNA-dependent; zinc ion binding" IPR016181; IPR005818; IPR002717; IPR011991; IPR011011; IPR001965; IPR019787; IPR013083; "Histone acetyltransferase KAT6B (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Protein querkopf)" Kat6b Myst4 Mus musculus (Mouse) TR39398_c0_g1_i2 Q8BRB7 KAT6B_MOUSE 2.00E-129 GO:0003677; GO:0070776; GO:0043966; GO:0004402; GO:0045892; GO:0000786; GO:0006334; GO:0045893; GO:0008134; GO:0006351; GO:0008270 "DNA binding; MOZ/MORF histone acetyltransferase complex; histone H3 acetylation; histone acetyltransferase activity; negative regulation of transcription, DNA-dependent; nucleosome; nucleosome assembly; positive regulation of transcription, DNA-dependent; transcription factor binding; transcription, DNA-dependent; zinc ion binding" IPR016181; IPR005818; IPR002717; IPR011991; IPR011011; IPR001965; IPR019787; IPR013083; "Histone acetyltransferase KAT6B (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Protein querkopf)" Kat6b Myst4 Mus musculus (Mouse) TR39399_c0_g1_i1 Q9JJ94 SSNA1_MOUSE 2.00E-37 GO:0005813; GO:0060830; GO:0005737; GO:0042073; GO:0005634 Q9QXJ2 centrosome; ciliary receptor clustering involved in smoothened signaling pathway; cytoplasm; intraflagellar transport; nucleus Sjoegren syndrome nuclear autoantigen 1 homolog Ssna1 MNCb-2711 Mus musculus (Mouse) TR39400_c5_g1_i1 Q6NZW8 AR8BA_DANRE 2.00E-25 GO:0005525; GO:0051301; GO:0007059; GO:0031902; GO:0005765; GO:0007067; GO:0007264; GO:0005819 GTP binding; cell division; chromosome segregation; late endosome membrane; lysosomal membrane; mitosis; small GTPase mediated signal transduction; spindle IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 8B-A arl8ba arl8b zgc:77187 Danio rerio (Zebrafish) (Brachydanio rerio) TR39400_c5_g2_i1 P61208 ARL4C_MOUSE 8.00E-66 GO:0005525; GO:0043014; GO:0005737; GO:0032456; GO:0030175; GO:0005886; GO:0007264 GTP binding; alpha-tubulin binding; cytoplasm; endocytic recycling; filopodium; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 4C (ADP-ribosylation factor-like 7) Arl4c Arl7 Mus musculus (Mouse) TR39400_c9_g3_i2 Q97GH9 ARGD_CLOAB 5.00E-19 GO:0003992; GO:0006526; GO:0005737; GO:0030170 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity; arginine biosynthetic process; cytoplasm; pyridoxal phosphate binding IPR005814; IPR015424; IPR015421; IPR015422; IPR004636; Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4. Acetylornithine aminotransferase (ACOAT) (EC 2.6.1.11) argD CA_C2388 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) TR39400_c9_g3_i3 P80404 GABT_HUMAN 2.00E-158 GO:0047298; GO:0003867; GO:0032144; GO:0048148; GO:0007620; GO:0009450; GO:0007626; GO:0005759; GO:0045776; GO:0043005; GO:0042135; GO:0007269; GO:0030170; GO:0042493; GO:0045471; GO:0001666; GO:0010039; GO:0035094; GO:0032145 P46108 (S)-3-amino-2-methylpropionate transaminase activity; 4-aminobutyrate transaminase activity; 4-aminobutyrate transaminase complex; behavioral response to cocaine; copulation; gamma-aminobutyric acid catabolic process; locomotory behavior; mitochondrial matrix; negative regulation of blood pressure; neuron projection; neurotransmitter catabolic process; neurotransmitter secretion; pyridoxal phosphate binding; response to drug; response to ethanol; response to hypoxia; response to iron ion; response to nicotine; succinate-semialdehyde dehydrogenase binding IPR004631; IPR005814; IPR015424; IPR015421; IPR015422; "4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT)" ABAT GABAT Homo sapiens (Human) TR39400_c9_g3_i4 Q728P4 BIOA_DESVH 8.00E-21 GO:0004015; GO:0009102; GO:0005737; GO:0030170 adenosylmethionine-8-amino-7-oxononanoate transaminase activity; biotin biosynthetic process; cytoplasm; pyridoxal phosphate binding IPR005814; IPR005815; IPR015424; IPR015421; IPR015422; "Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1." "Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) (7,8-diamino-pelargonic acid aminotransferase) (DAPA AT) (DAPA aminotransferase) (7,8-diaminononanoate synthase) (DANS) (Diaminopelargonic acid synthase)" bioA DVU_2559 Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) TR39400_c9_g4_i3 P80147 GABT_PIG 4.00E-17 GO:0047298; GO:0003867; GO:0032144; GO:0048148; GO:0005829; GO:0009450; GO:0005759; GO:0042135; GO:0042803; GO:0030170; GO:0032145 (S)-3-amino-2-methylpropionate transaminase activity; 4-aminobutyrate transaminase activity; 4-aminobutyrate transaminase complex; behavioral response to cocaine; cytosol; gamma-aminobutyric acid catabolic process; mitochondrial matrix; neurotransmitter catabolic process; protein homodimerization activity; pyridoxal phosphate binding; succinate-semialdehyde dehydrogenase binding IPR004631; IPR005814; IPR015424; IPR015421; IPR015422; "4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT)" ABAT GABAT Sus scrofa (Pig) TR39401_c1_g1_i1 Q6NYY9 VMP1_DANRE 5.00E-152 GO:0005783; GO:0033116; GO:0016021; GO:0005886; GO:0005774 endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; plasma membrane; vacuolar membrane Vacuole membrane protein 1 (Transmembrane protein 49) vmp1 tmem49 Danio rerio (Zebrafish) (Brachydanio rerio) TR39402_c1_g3_i1 Q15061 WDR43_HUMAN 8.00E-138 GO:0005730 nucleolus IPR007148; IPR015943; IPR001680; IPR017986; WD repeat-containing protein 43 WDR43 KIAA0007 UTP5 Homo sapiens (Human) TR39403_c1_g1_i1 P85107 TGS1_RAT 1.00E-96 GO:0009452; GO:0071164; GO:0005737; GO:0005634; GO:0006355; GO:0006351 "7-methylguanosine RNA capping; RNA trimethylguanosine synthase activity; cytoplasm; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019012; Trimethylguanosine synthase (EC 2.1.1.-) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) Tgs1 Ncoa6ip Pimt Rattus norvegicus (Rat) TR39403_c4_g1_i1 B6YXI6 TBP_THEON 6.00E-17 GO:0003677; GO:0006352; GO:0003700 "DNA binding; DNA-dependent transcription, initiation; sequence-specific DNA binding transcription factor activity" IPR012295; IPR000814; TATA-box-binding protein (Box A-binding protein) (BAP) (TATA sequence-binding protein) (TBP) (TATA-box factor) tbp TON_1309 Thermococcus onnurineus (strain NA1) TR39403_c4_g1_i2 P27633 TBP_XENLA 1.00E-60 GO:0003677; GO:0009790; GO:0006355; GO:0005669; GO:0006367 "DNA binding; embryo development; regulation of transcription, DNA-dependent; transcription factor TFIID complex; transcription initiation from RNA polymerase II promoter" IPR012295; IPR000814; TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit) tbp tfiid Xenopus laevis (African clawed frog) TR39403_c4_g2_i1 P53361 TBP_SPOFR 2.00E-54 GO:0003677; GO:0006352; GO:0005634 "DNA binding; DNA-dependent transcription, initiation; nucleus" IPR012295; IPR000814; TATA-box-binding protein (TATA sequence-binding protein) (TBP) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit) Tbp Spodoptera frugiperda (Fall armyworm) TR39404_c1_g1_i1 Q9UKP4 ATS7_HUMAN 5.00E-31 GO:0009986; GO:0004222; GO:0008237; GO:0005578; GO:0006508; GO:0008270 cell surface; metalloendopeptidase activity; metallopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS 7) (ADAM-TS7) (ADAMTS-7) (EC 3.4.24.-) (COMPase) ADAMTS7 Homo sapiens (Human) TR39404_c1_g2_i1 P59509 ATS19_MOUSE 4.00E-13 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 19 (ADAM-TS 19) (ADAM-TS19) (ADAMTS-19) (EC 3.4.24.-) Adamts19 Mus musculus (Mouse) TR39408_c0_g1_i1 A3KPW9 BAG6_DANRE 1.00E-48 GO:0071818; GO:0007420; GO:0016568; GO:0009790; GO:0018393; GO:0042771; GO:0070059; GO:0001822; GO:0030324; GO:0032435; GO:0005634; GO:0031593; GO:0070628; GO:0050821; GO:0042981; GO:0043022; GO:0007283; GO:0007130; GO:0071816; GO:0006810; GO:0006511 BAT3 complex; brain development; chromatin modification; embryo development; internal peptidyl-lysine acetylation; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; kidney development; lung development; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; nucleus; polyubiquitin binding; proteasome binding; protein stabilization; regulation of apoptotic process; ribosome binding; spermatogenesis; synaptonemal complex assembly; tail-anchored membrane protein insertion into ER membrane; transport; ubiquitin-dependent protein catabolic process IPR021925; IPR000626; Large proline-rich protein BAG6 (BCL2-associated athanogene 6) (HLA-B-associated transcript 3) Bag6 Bat3 si:ch211-215a10.6 Danio rerio (Zebrafish) (Brachydanio rerio) TR39408_c0_g3_i1 Q6MG49 BAG6_RAT 1.00E-20 GO:0071818; GO:0007420; GO:0030154; GO:0016568; GO:0009790; GO:0018393; GO:0042771; GO:0070059; GO:0001822; GO:0030324; GO:0032435; GO:0005634; GO:0031593; GO:0070628; GO:0050821; GO:0042127; GO:0043022; GO:0007283; GO:0007130; GO:0071816; GO:0006810; GO:0006511 BAT3 complex; brain development; cell differentiation; chromatin modification; embryo development; internal peptidyl-lysine acetylation; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; kidney development; lung development; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; nucleus; polyubiquitin binding; proteasome binding; protein stabilization; regulation of cell proliferation; ribosome binding; spermatogenesis; synaptonemal complex assembly; tail-anchored membrane protein insertion into ER membrane; transport; ubiquitin-dependent protein catabolic process IPR021925; IPR019954; IPR000626; Large proline-rich protein BAG6 (BCL2-associated athanogene 6) (HLA-B-associated transcript 3) Bag6 Bat3 Rattus norvegicus (Rat) TR39410_c1_g2_i1 Q92213 VPS34_CANAX 1.00E-98 GO:0016303; GO:0005524; GO:0036092; GO:0048015 1-phosphatidylinositol-3-kinase activity; ATP binding; phosphatidylinositol-3-phosphate biosynthetic process; phosphatidylinositol-mediated signaling IPR016024; IPR000008; IPR011009; IPR000403; IPR018936; IPR002420; IPR008290; IPR015433; IPR001263; Phosphatidylinositol 3-kinase VPS34 (PI3-kinase VPS34) (PI3K VPS34) (PtdIns-3-kinase VPS34) (EC 2.7.1.137) (Vacuolar protein sorting-associated protein 34) VPS34 Candida albicans (Yeast) TR39410_c1_g2_i2 Q6AZN6 PK3C3_XENLA 0 GO:0016303; GO:0005524; GO:0006914; GO:0000910; GO:0030496; GO:0048015 1-phosphatidylinositol-3-kinase activity; ATP binding; autophagy; cytokinesis; midbody; phosphatidylinositol-mediated signaling IPR016024; IPR000008; IPR011009; IPR000403; IPR018936; IPR002420; IPR008290; IPR015433; IPR001263; Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphoinositide-3-kinase class 3) pik3c3 Xenopus laevis (African clawed frog) TR39411_c2_g5_i5 Q3SYU1 NOC2L_BOVIN 1.00E-169 GO:0006915; GO:0034644; GO:0031497; GO:0003682; GO:0002903; GO:0035067; GO:2001243; GO:0000122; GO:0005730; GO:0032066; GO:0005654; GO:0003714; GO:0006351 "apoptotic process; cellular response to UV; chromatin assembly; chromatin binding; negative regulation of B cell apoptotic process; negative regulation of histone acetylation; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleolus; nucleolus to nucleoplasm transport; nucleoplasm; transcription corepressor activity; transcription, DNA-dependent" IPR016024; IPR005343; Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) NOC2L NIR Bos taurus (Bovine) TR39411_c2_g5_i8 Q3SYU1 NOC2L_BOVIN 6.00E-39 GO:0006915; GO:0034644; GO:0031497; GO:0003682; GO:0002903; GO:0035067; GO:2001243; GO:0000122; GO:0005730; GO:0032066; GO:0005654; GO:0003714; GO:0006351 "apoptotic process; cellular response to UV; chromatin assembly; chromatin binding; negative regulation of B cell apoptotic process; negative regulation of histone acetylation; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleolus; nucleolus to nucleoplasm transport; nucleoplasm; transcription corepressor activity; transcription, DNA-dependent" IPR016024; IPR005343; Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) NOC2L NIR Bos taurus (Bovine) TR39412_c0_g1_i1 P25916 BMI1_MOUSE 2.00E-72 GO:0031519; GO:0007420; GO:0003682; GO:0005737; GO:0048704; GO:0016573; GO:0016574; GO:0006959; GO:0001701; GO:2001234; GO:0000122; GO:0016604; GO:0030890; GO:0033092; GO:0051443; GO:0021903; GO:0043565; GO:0048103; GO:0006351; GO:0000151; GO:0008270 Q9QXV1; Q8IXK0; Q9QWH1; O35730; Q9CQJ4 "PcG protein complex; brain development; chromatin binding; cytoplasm; embryonic skeletal system morphogenesis; histone acetylation; histone ubiquitination; humoral immune response; in utero embryonic development; negative regulation of apoptotic signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nuclear body; positive regulation of B cell proliferation; positive regulation of immature T cell proliferation in thymus; positive regulation of ubiquitin-protein ligase activity; rostrocaudal neural tube patterning; sequence-specific DNA binding; somatic stem cell division; transcription, DNA-dependent; ubiquitin ligase complex; zinc ion binding" IPR018957; IPR001841; IPR013083; IPR017907; Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) Bmi1 Bmi-1 Pcgf4 Mus musculus (Mouse) TR39413_c0_g1_i3 P36776 LONM_HUMAN 0 GO:0043531; GO:0005524; GO:0004176; GO:0051880; GO:0007568; GO:0034599; GO:0051131; GO:0006515; GO:0032042; GO:0070362; GO:0070361; GO:0042645; GO:0070407; GO:0051260; GO:0090296; GO:0010044; GO:0009725; GO:0001666; GO:0043565; GO:0004252; GO:0003697; GO:0003727 ADP binding; ATP binding; ATP-dependent peptidase activity; G-quadruplex DNA binding; aging; cellular response to oxidative stress; chaperone-mediated protein complex assembly; misfolded or incompletely synthesized protein catabolic process; mitochondrial DNA metabolic process; mitochondrial heavy strand promoter anti-sense binding; mitochondrial light strand promoter anti-sense binding; mitochondrial nucleoid; oxidation-dependent protein catabolic process; protein homooligomerization; regulation of mitochondrial DNA replication; response to aluminum ion; response to hormone stimulus; response to hypoxia; sequence-specific DNA binding; serine-type endopeptidase activity; single-stranded DNA binding; single-stranded RNA binding IPR003593; IPR003959; IPR004815; IPR027065; IPR027503; IPR027417; IPR008269; IPR003111; IPR008268; IPR015947; IPR020568; IPR014721; "Lon protease homolog, mitochondrial (EC 3.4.21.-) (LONHs) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15)" LONP1 PRSS15 Homo sapiens (Human) TR39413_c0_g1_i5 Q8CGK3 LONM_MOUSE 0 GO:0043531; GO:0005524; GO:0004176; GO:0051880; GO:0034599; GO:0051131; GO:0006515; GO:0070361; GO:0042645; GO:0007005; GO:0070407; GO:0051260; GO:0090296; GO:0001666; GO:0043565; GO:0004252; GO:0003697; GO:0003727 ADP binding; ATP binding; ATP-dependent peptidase activity; G-quadruplex DNA binding; cellular response to oxidative stress; chaperone-mediated protein complex assembly; misfolded or incompletely synthesized protein catabolic process; mitochondrial light strand promoter anti-sense binding; mitochondrial nucleoid; mitochondrion organization; oxidation-dependent protein catabolic process; protein homooligomerization; regulation of mitochondrial DNA replication; response to hypoxia; sequence-specific DNA binding; serine-type endopeptidase activity; single-stranded DNA binding; single-stranded RNA binding IPR003593; IPR003959; IPR004815; IPR027065; IPR027503; IPR027417; IPR008269; IPR003111; IPR008268; IPR015947; IPR020568; IPR014721; "Lon protease homolog, mitochondrial (EC 3.4.21.-) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15)" Lonp1 Prss15 Mus musculus (Mouse) TR39414_c2_g1_i1 Q8BWJ3 KPB2_MOUSE 7.00E-87 GO:0005977; GO:0004553; GO:0005886 "glycogen metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; plasma membrane" IPR008928; IPR011613; IPR008734; Glycan biosynthesis; glycogen metabolism. "Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit)" Phka2 Mus musculus (Mouse) TR39414_c2_g1_i10 Q9W391 KPBA_DROME 2.00E-93 GO:0005977; GO:0004553; GO:0005886 "glycogen metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; plasma membrane" IPR008928; IPR012341; IPR011613; IPR008734; Glycan biosynthesis; glycogen metabolism. Probable phosphorylase b kinase regulatory subunit alpha (Phosphorylase kinase subunit alpha) CG7766 Drosophila melanogaster (Fruit fly) TR39414_c2_g1_i2 Q9W391 KPBA_DROME 7.00E-137 GO:0005977; GO:0004553; GO:0005886 "glycogen metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; plasma membrane" IPR008928; IPR012341; IPR011613; IPR008734; Glycan biosynthesis; glycogen metabolism. Probable phosphorylase b kinase regulatory subunit alpha (Phosphorylase kinase subunit alpha) CG7766 Drosophila melanogaster (Fruit fly) TR39414_c2_g1_i3 P46018 KPB2_RABIT 1.00E-68 GO:0005977; GO:0004553; GO:0005886 "glycogen metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; plasma membrane" IPR008928; IPR011613; IPR008734; Glycan biosynthesis; glycogen metabolism. "Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit)" PHKA2 Oryctolagus cuniculus (Rabbit) TR39414_c2_g1_i4 P46020 KPB1_HUMAN 2.00E-112 GO:0005829; GO:0006006; GO:0005980; GO:0004553; GO:0004689; GO:0005886; GO:0044281 "cytosol; glucose metabolic process; glycogen catabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; phosphorylase kinase activity; plasma membrane; small molecule metabolic process" IPR008928; IPR012341; IPR011613; IPR008734; Glycan biosynthesis; glycogen metabolism. "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit)" PHKA1 PHKA Homo sapiens (Human) TR39414_c2_g1_i6 Q9W391 KPBA_DROME 5.00E-143 GO:0005977; GO:0004553; GO:0005886 "glycogen metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; plasma membrane" IPR008928; IPR012341; IPR011613; IPR008734; Glycan biosynthesis; glycogen metabolism. Probable phosphorylase b kinase regulatory subunit alpha (Phosphorylase kinase subunit alpha) CG7766 Drosophila melanogaster (Fruit fly) TR39414_c2_g1_i7 P18688 KPB1_RABIT 1.00E-68 GO:0005977; GO:0004553; GO:0005886 "glycogen metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; plasma membrane" IPR008928; IPR012341; IPR011613; IPR008734; Glycan biosynthesis; glycogen metabolism. "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit)" PHKA1 Oryctolagus cuniculus (Rabbit) TR39416_c0_g1_i1 Q91WQ5 TAF5L_MOUSE 2.00E-98 GO:0030914; GO:0043966; GO:0004402; GO:0006355; GO:0003713; GO:0033276; GO:0006351 "STAGA complex; histone H3 acetylation; histone acetyltransferase activity; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription factor TFTC complex; transcription, DNA-dependent" IPR020472; IPR007582; IPR015943; IPR001680; IPR019775; IPR017986; TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65-beta) Taf5l Paf65b Mus musculus (Mouse) TR39416_c0_g1_i2 Q15542 TAF5_HUMAN 0 GO:0015629; GO:0016573; GO:0019048; GO:0046983; GO:0003700; GO:0006368; GO:0005669; GO:0033276; GO:0006367; GO:0044212; GO:0016032 actin cytoskeleton; histone acetylation; modulation by virus of host morphology or physiology; protein dimerization activity; sequence-specific DNA binding transcription factor activity; transcription elongation from RNA polymerase II promoter; transcription factor TFIID complex; transcription factor TFTC complex; transcription initiation from RNA polymerase II promoter; transcription regulatory region DNA binding; viral process IPR020472; IPR006594; IPR007582; IPR015943; IPR001680; IPR019775; IPR017986; Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100) TAF5 TAF2D Homo sapiens (Human) TR39416_c0_g1_i3 Q91WQ5 TAF5L_MOUSE 3.00E-109 GO:0030914; GO:0043966; GO:0004402; GO:0006355; GO:0003713; GO:0033276; GO:0006351 "STAGA complex; histone H3 acetylation; histone acetyltransferase activity; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription factor TFTC complex; transcription, DNA-dependent" IPR020472; IPR007582; IPR015943; IPR001680; IPR019775; IPR017986; TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65-beta) Taf5l Paf65b Mus musculus (Mouse) TR39416_c0_g1_i4 Q15542 TAF5_HUMAN 0 GO:0015629; GO:0016573; GO:0019048; GO:0046983; GO:0003700; GO:0006368; GO:0005669; GO:0033276; GO:0006367; GO:0044212; GO:0016032 actin cytoskeleton; histone acetylation; modulation by virus of host morphology or physiology; protein dimerization activity; sequence-specific DNA binding transcription factor activity; transcription elongation from RNA polymerase II promoter; transcription factor TFIID complex; transcription factor TFTC complex; transcription initiation from RNA polymerase II promoter; transcription regulatory region DNA binding; viral process IPR020472; IPR006594; IPR007582; IPR015943; IPR001680; IPR019775; IPR017986; Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100) TAF5 TAF2D Homo sapiens (Human) TR39417_c0_g1_i2 Q8BQM4 HEAT3_MOUSE 1.00E-26 IPR011989; IPR016024; HEAT repeat-containing protein 3 Heatr3 Mus musculus (Mouse) TR39417_c0_g1_i3 Q7Z4Q2 HEAT3_HUMAN 1.00E-40 IPR011989; IPR016024; HEAT repeat-containing protein 3 HEATR3 Homo sapiens (Human) TR39419_c1_g1_i2 Q5M8K8 RABL5_XENTR 9.00E-66 GO:0005525; GO:0007264 GTP binding; small GTPase mediated signal transduction IPR027417; IPR001806; Rab-like protein 5 rabl5 TGas031j16.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39419_c1_g1_i3 Q4R4K5 RABL5_MACFA 2.00E-61 GO:0005525; GO:0007264 GTP binding; small GTPase mediated signal transduction IPR027417; IPR001806; Rab-like protein 5 RABL5 QnpA-17728 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR39420_c0_g1_i1 Q93DW6 PYRG_MYCCC 2.00E-12 GO:0044210; GO:0005524; GO:0003883; GO:0006541 'de novo' CTP biosynthetic process; ATP binding; CTP synthase activity; glutamine metabolic process IPR004468; IPR017926; Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. CTP synthase (EC 6.3.4.2) (CTP synthetase) (UTP--ammonia ligase) (Fragment) pyrG Mycoplasma capricolum subsp. capripneumoniae TR39420_c0_g1_i2 P17812 PYRG1_HUMAN 0 GO:0044210; GO:0005524; GO:0006241; GO:0003883; GO:0005829; GO:0006541; GO:0015949; GO:0042493 'de novo' CTP biosynthetic process; ATP binding; CTP biosynthetic process; CTP synthase activity; cytosol; glutamine metabolic process; nucleobase-containing small molecule interconversion; response to drug IPR004468; IPR017456; IPR017926; IPR027417; Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1) CTPS1 CTPS Homo sapiens (Human) TR39420_c0_g1_i3 Q5XHA8 PYG1A_XENLA 0 GO:0044210; GO:0005524; GO:0003883; GO:0006541 'de novo' CTP biosynthetic process; ATP binding; CTP synthase activity; glutamine metabolic process IPR004468; IPR017456; IPR017926; IPR027417; Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. CTP synthase 1-A (EC 6.3.4.2) (CTP synthetase 1-A) (UTP--ammonia ligase 1-A) ctps1-a Xenopus laevis (African clawed frog) TR39420_c0_g1_i4 A5FXW7 PYRG_ACICJ 1.00E-111 GO:0044210; GO:0005524; GO:0003883; GO:0006541 'de novo' CTP biosynthetic process; ATP binding; CTP synthase activity; glutamine metabolic process IPR004468; IPR017456; IPR017926; IPR027417; Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. CTP synthase (EC 6.3.4.2) (CTP synthetase) (UTP--ammonia ligase) pyrG Acry_1238 Acidiphilium cryptum (strain JF-5) TR39420_c0_g1_i5 Q65DT7 PYRG_BACLD 3.00E-136 GO:0044210; GO:0005524; GO:0003883; GO:0006541 'de novo' CTP biosynthetic process; ATP binding; CTP synthase activity; glutamine metabolic process IPR004468; IPR017456; IPR017926; IPR027417; Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. CTP synthase (EC 6.3.4.2) (CTP synthetase) (UTP--ammonia ligase) pyrG BLi03963 BL03966 Bacillus licheniformis (strain DSM 13 / ATCC 14580) TR39420_c0_g1_i6 Q5XHA8 PYG1A_XENLA 0 GO:0044210; GO:0005524; GO:0003883; GO:0006541 'de novo' CTP biosynthetic process; ATP binding; CTP synthase activity; glutamine metabolic process IPR004468; IPR017456; IPR017926; IPR027417; Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. CTP synthase 1-A (EC 6.3.4.2) (CTP synthetase 1-A) (UTP--ammonia ligase 1-A) ctps1-a Xenopus laevis (African clawed frog) TR39420_c0_g1_i7 O42644 PYRG_SCHPO 0 GO:0044210; GO:0006207; GO:0005524; GO:0003883; GO:0006995; GO:0005829; GO:0006541; GO:0070317 'de novo' CTP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; ATP binding; CTP synthase activity; cellular response to nitrogen starvation; cytosol; glutamine metabolic process; negative regulation of G0 to G1 transition IPR004468; IPR017456; IPR017926; IPR027417; Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. CTP synthase (EC 6.3.4.2) (CTP synthetase) (UTP--ammonia ligase) ura7 SPAC10F6.03c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR39420_c0_g1_i8 Q5XHA8 PYG1A_XENLA 0 GO:0044210; GO:0005524; GO:0003883; GO:0006541 'de novo' CTP biosynthetic process; ATP binding; CTP synthase activity; glutamine metabolic process IPR004468; IPR017456; IPR017926; IPR027417; Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. CTP synthase 1-A (EC 6.3.4.2) (CTP synthetase 1-A) (UTP--ammonia ligase 1-A) ctps1-a Xenopus laevis (African clawed frog) TR39421_c0_g1_i3 Q4R6T7 IQUB_MACFA 0 GO:0030030 cell projection organization IPR000626; IQ and ubiquitin-like domain-containing protein IQUB QtsA-17155 QtsA-17428 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR39422_c0_g2_i2 Q6P632 NAA20_XENTR 7.00E-103 GO:0005737; GO:0005634; GO:0004596 cytoplasm; nucleus; peptide alpha-N-acetyltransferase activity IPR016181; IPR000182; N-alpha-acetyltransferase 20 (EC 2.3.1.88) (Methionine N-acetyltransferase) (N-acetyltransferase 5) (N-terminal acetyltransferase B complex catalytic subunit NAA20) (N-terminal acetyltransferase B complex catalytic subunit NAT5) (NatB complex subunit NAT5) (NatB catalytic subunit) naa20 nat5 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39424_c0_g2_i1 Q9NPA2 MMP25_HUMAN 8.00E-108 GO:0031225; GO:0005509; GO:0009986; GO:0060022; GO:0006954; GO:0016020; GO:0004222; GO:0005886; GO:0005578; GO:0006508; GO:0008270 anchored to membrane; calcium ion binding; cell surface; hard palate development; inflammatory response; membrane; metalloendopeptidase activity; plasma membrane; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000585; IPR018487; IPR024079; IPR001818; IPR021190; IPR016293; IPR006026; IPR002477; Matrix metalloproteinase-25 (MMP-25) (EC 3.4.24.-) (Leukolysin) (Membrane-type matrix metalloproteinase 6) (MT-MMP 6) (MTMMP6) (Membrane-type-6 matrix metalloproteinase) (MT6-MMP) (MT6MMP) MMP25 MMP20 MMPL1 MT6MMP Homo sapiens (Human) TR39424_c0_g2_i2 Q9NPA2 MMP25_HUMAN 7.00E-108 GO:0031225; GO:0005509; GO:0009986; GO:0060022; GO:0006954; GO:0016020; GO:0004222; GO:0005886; GO:0005578; GO:0006508; GO:0008270 anchored to membrane; calcium ion binding; cell surface; hard palate development; inflammatory response; membrane; metalloendopeptidase activity; plasma membrane; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000585; IPR018487; IPR024079; IPR001818; IPR021190; IPR016293; IPR006026; IPR002477; Matrix metalloproteinase-25 (MMP-25) (EC 3.4.24.-) (Leukolysin) (Membrane-type matrix metalloproteinase 6) (MT-MMP 6) (MTMMP6) (Membrane-type-6 matrix metalloproteinase) (MT6-MMP) (MT6MMP) MMP25 MMP20 MMPL1 MT6MMP Homo sapiens (Human) TR39426_c0_g1_i1 Q7ZUC2 CAB45_DANRE 4.00E-24 GO:0005796; GO:0005509 Golgi lumen; calcium ion binding IPR027240; IPR011992; IPR018247; IPR002048; 45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4) sdf4 cab45 zgc:76916 Danio rerio (Zebrafish) (Brachydanio rerio) TR39426_c0_g1_i2 B5X4E0 CALUB_SALSA 9.00E-114 GO:0005509; GO:0005576; GO:0042470; GO:0033018 calcium ion binding; extracellular region; melanosome; sarcoplasmic reticulum lumen IPR027239; IPR011992; IPR018247; IPR002048; Calumenin-B calub Salmo salar (Atlantic salmon) TR39426_c0_g1_i4 B5X4E0 CALUB_SALSA 9.00E-114 GO:0005509; GO:0005576; GO:0042470; GO:0033018 calcium ion binding; extracellular region; melanosome; sarcoplasmic reticulum lumen IPR027239; IPR011992; IPR018247; IPR002048; Calumenin-B calub Salmo salar (Atlantic salmon) TR39428_c2_g1_i1 Q6P7B7 ZFY27_RAT 8.00E-19 GO:0030424; GO:0030425; GO:0005783; GO:0005789; GO:0032584; GO:0016021; GO:0046872; GO:0031175; GO:0048011; GO:0072659; GO:0055038 axon; dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; growth cone membrane; integral to membrane; metal ion binding; neuron projection development; neurotrophin TRK receptor signaling pathway; protein localization to plasma membrane; recycling endosome membrane IPR000306; IPR017455; IPR011011; IPR013083; Protrudin (Zinc finger FYVE domain-containing protein 27) Zfyve27 Rattus norvegicus (Rat) TR39429_c1_g1_i1 Q9NUV9 GIMA4_HUMAN 7.00E-12 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR39431_c6_g2_i1 Q9XFG3 TBG_PHYPA 0 GO:0005525; GO:0003924; GO:0031122; GO:0000930; GO:0005874; GO:0007020; GO:0051258 GTP binding; GTPase activity; cytoplasmic microtubule organization; gamma-tubulin complex; microtubule; microtubule nucleation; protein polymerization IPR002454; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin gamma chain (Gamma-tubulin) TUBG1 PHYPADRAFT_170153 Physcomitrella patens subsp. patens (Moss) TR39431_c6_g2_i2 P23330 TBG1_XENLA 0 GO:0005525; GO:0003924; GO:0005813; GO:0005737; GO:0031122; GO:0000930; GO:0007020; GO:0005827; GO:0051258 GTP binding; GTPase activity; centrosome; cytoplasm; cytoplasmic microtubule organization; gamma-tubulin complex; microtubule nucleation; polar microtubule; protein polymerization IPR002454; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin gamma-1 chain (Gamma-1-tubulin) (xGAM) tubg1 Xenopus laevis (African clawed frog) TR39432_c1_g1_i1 Q9BZW5 TM6S1_HUMAN 2.00E-53 GO:0016021; GO:0016020 integral to membrane; membrane IPR016964; Transmembrane 6 superfamily member 1 TM6SF1 Homo sapiens (Human) TR39432_c2_g2_i1 A9A9Q2 RS4E_METM6 2.00E-38 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR000876; IPR013845; IPR013843; IPR018199; IPR002942; 30S ribosomal protein S4e rps4e MmarC6_1262 Methanococcus maripaludis (strain C6 / ATCC BAA-1332) TR39432_c2_g2_i2 Q4PMB3 RS4_IXOSC 2.00E-144 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR005824; IPR000876; IPR013845; IPR013843; IPR018199; IPR002942; 40S ribosomal protein S4 RpS4 Ixodes scapularis (Black-legged tick) (Deer tick) TR39432_c2_g2_i3 A4FWA9 RS4E_METM5 6.00E-39 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR005824; IPR000876; IPR013845; IPR013843; IPR018199; IPR002942; 30S ribosomal protein S4e rps4e MmarC5_0167 Methanococcus maripaludis (strain C5 / ATCC BAA-1333) TR39432_c2_g2_i5 P47837 RS4_CANAX 8.00E-118 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR005824; IPR000876; IPR013845; IPR013843; IPR018199; IPR002942; 40S ribosomal protein S4 (S7) RPS4 RPS7 Candida albicans (Yeast) TR39432_c2_g2_i6 Q9YF85 RS4E_AERPE 6.00E-42 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR000876; IPR013845; IPR013843; IPR002942; 30S ribosomal protein S4e rps4e APE_0356.1 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) TR39432_c2_g2_i7 Q4PMB3 RS4_IXOSC 3.00E-144 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR005824; IPR000876; IPR013845; IPR013843; IPR018199; IPR002942; 40S ribosomal protein S4 RpS4 Ixodes scapularis (Black-legged tick) (Deer tick) TR39433_c0_g1_i1 Q9ES30 C1QT3_MOUSE 8.00E-09 GO:0005581; GO:0005615; GO:0042593; GO:0042802; GO:0045721; GO:0070374; GO:0070165; GO:0050715; GO:0051897; GO:0051259 collagen; extracellular space; glucose homeostasis; identical protein binding; negative regulation of gluconeogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of adiponectin secretion; positive regulation of cytokine secretion; positive regulation of protein kinase B signaling cascade; protein oligomerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1qtnf3 Cors26 Ctrp3 Mus musculus (Mouse) TR39433_c1_g3_i1 P83425 HIP_MYTED 6.00E-08 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR39433_c1_g3_i2 Q9JHG0 CBLN3_MOUSE 3.00E-08 GO:0005794; GO:0030054; GO:0005783; GO:0005615; GO:0045202 Golgi apparatus; cell junction; endoplasmic reticulum; extracellular space; synapse IPR001073; IPR008983; Cerebellin-3 Cbln3 Mus musculus (Mouse) TR39433_c1_g3_i3 Q8R066 C1QT4_MOUSE 7.00E-08 GO:0005615 extracellular space IPR001073; IPR008983; Complement C1q tumor necrosis factor-related protein 4 C1qtnf4 Mus musculus (Mouse) TR39433_c1_g4_i1 Q5EBL8 PDZ11_HUMAN 3.00E-31 GO:0016323; GO:0005737; GO:0005829; GO:0005576 Q04656 basolateral plasma membrane; cytoplasm; cytosol; extracellular region IPR001478; PDZ domain-containing protein 11 (ATPase-interacting PDZ protein) (Plasma membrane calcium ATPase-interacting single-PDZ protein) (PMCA-interacting single-PDZ protein) PDZD11 AIPP1 PDZK11 PISP HSPC227 UNQ6486/PRO21335 Homo sapiens (Human) TR39434_c2_g1_i1 Q5RD48 OCAD1_PONAB 1.00E-08 GO:0005768; GO:0005739 endosome; mitochondrion IPR009764; OCIA domain-containing protein 1 OCIAD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39435_c0_g1_i2 Q7Z401 MYCPP_HUMAN 8.00E-52 GO:0003677; GO:0017112; GO:0005634; GO:0006355; GO:0006351 "DNA binding; Rab guanyl-nucleotide exchange factor activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR005112; IPR001194; IPR023341; IPR002885; IPR005113; C-myc promoter-binding protein (DENN domain-containing protein 4A) DENND4A IRLB MYCPBP Homo sapiens (Human) TR39437_c3_g2_i1 O76337 CED6_CAEEL 1.00E-49 GO:0006915; GO:0043652; GO:0009898; GO:0007275; GO:0045335; GO:0012501; GO:0045309 apoptotic process; engulfment of apoptotic cell; internal side of plasma membrane; multicellular organismal development; phagocytic vesicle; programmed cell death; protein phosphorylated amino acid binding IPR011993; IPR006020; Cell death protein 6 (Candidate adapter protein ced-6) ced-6 F56D2.7 Caenorhabditis elegans TR39437_c3_g2_i8 Q5PQS4 GULP1_RAT 1.00E-77 GO:0006915; GO:0005737; GO:0006869; GO:0006911 "apoptotic process; cytoplasm; lipid transport; phagocytosis, engulfment" IPR011993; IPR006020; PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP) Gulp1 Ced6 Rattus norvegicus (Rat) TR39439_c0_g1_i1 Q13360 ZN177_HUMAN 1.00E-37 GO:0003677; GO:0046872; GO:0000122; GO:0005634; GO:0006351 "DNA binding; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 177 ZNF177 Homo sapiens (Human) TR39439_c0_g1_i2 P17023 ZNF19_HUMAN 2.00E-33 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 19 (Zinc finger protein KOX12) ZNF19 KOX12 Homo sapiens (Human) TR39441_c5_g1_i3 Q95SX7 RTBS_DROME 4.00E-23 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR39442_c1_g2_i1 Q9LZG0 ADK2_ARATH 5.00E-124 GO:0044209; GO:0005524; GO:0004001; GO:0006169; GO:0005507; GO:0005829; GO:0019048; GO:0016773; GO:0005886 "AMP salvage; ATP binding; adenosine kinase activity; adenosine salvage; copper ion binding; cytosol; modulation by virus of host morphology or physiology; phosphotransferase activity, alcohol group as acceptor; plasma membrane" IPR001805; IPR002173; IPR011611; Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1. Adenosine kinase 2 (AK 2) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase 2) ADK2 At5g03300 F12E4.30 MOK16.21 Arabidopsis thaliana (Mouse-ear cress) TR39442_c1_g2_i2 Q9LZG0 ADK2_ARATH 5.00E-127 GO:0044209; GO:0005524; GO:0004001; GO:0006169; GO:0005507; GO:0005829; GO:0019048; GO:0016773; GO:0005886 "AMP salvage; ATP binding; adenosine kinase activity; adenosine salvage; copper ion binding; cytosol; modulation by virus of host morphology or physiology; phosphotransferase activity, alcohol group as acceptor; plasma membrane" IPR001805; IPR002173; IPR011611; Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1. Adenosine kinase 2 (AK 2) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase 2) ADK2 At5g03300 F12E4.30 MOK16.21 Arabidopsis thaliana (Mouse-ear cress) TR39445_c1_g1_i4 Q8N695 SC5A8_HUMAN 4.00E-123 GO:0016324; GO:0006915; GO:0016021; GO:0006811; GO:0005886; GO:0006814; GO:0015293; GO:0055085 apical plasma membrane; apoptotic process; integral to membrane; ion transport; plasma membrane; sodium ion transport; symporter activity; transmembrane transport IPR001734; IPR019900; Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8) SLC5A8 AIT SMCT SMCT1 Homo sapiens (Human) TR39447_c0_g1_i1 Q29554 ECHA_PIG 0 GO:0003857; GO:0050662; GO:0004300; GO:0006635; GO:0016509; GO:0016507; GO:0005743; GO:0042645; GO:0005730; GO:0032868 3-hydroxyacyl-CoA dehydrogenase activity; coenzyme binding; enoyl-CoA hydratase activity; fatty acid beta-oxidation; long-chain-3-hydroxyacyl-CoA dehydrogenase activity; mitochondrial fatty acid beta-oxidation multienzyme complex; mitochondrial inner membrane; mitochondrial nucleoid; nucleolus; response to insulin stimulus IPR006180; IPR006176; IPR006108; IPR008927; IPR001753; IPR013328; IPR018376; IPR012803; IPR016040; Lipid metabolism; fatty acid beta-oxidation. "Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)]" HADHA LCHYD-HAD Sus scrofa (Pig) TR39448_c0_g1_i1 Q9VSF4 DHYS_DROME 2.00E-120 GO:0050983; GO:0034038; GO:0008612 deoxyhypusine biosynthetic process from spermidine; deoxyhypusine synthase activity; peptidyl-lysine modification to hypusine IPR002773; Protein modification; eIF5A hypusination. Probable deoxyhypusine synthase (DHS) (EC 2.5.1.46) CG8005 Drosophila melanogaster (Fruit fly) TR39448_c0_g1_i2 B5APK2 DHYS_LEIDO 5.00E-10 GO:0050983; GO:0034038; GO:0008612; GO:0042803 deoxyhypusine biosynthetic process from spermidine; deoxyhypusine synthase activity; peptidyl-lysine modification to hypusine; protein homodimerization activity IPR002773; Protein modification; eIF5A hypusination. Deoxyhypusine synthase (DHS) (EC 2.5.1.46) (Deoxyhypusine synthase from chromosome 34) (DHS34) Leishmania donovani TR39448_c0_g1_i3 B5APK2 DHYS_LEIDO 7.00E-11 GO:0050983; GO:0034038; GO:0008612; GO:0042803 deoxyhypusine biosynthetic process from spermidine; deoxyhypusine synthase activity; peptidyl-lysine modification to hypusine; protein homodimerization activity IPR002773; Protein modification; eIF5A hypusination. Deoxyhypusine synthase (DHS) (EC 2.5.1.46) (Deoxyhypusine synthase from chromosome 34) (DHS34) Leishmania donovani TR39448_c0_g1_i5 Q6AY53 DHYS_RAT 7.00E-121 GO:0050983; GO:0034038; GO:0008612; GO:0051289 deoxyhypusine biosynthetic process from spermidine; deoxyhypusine synthase activity; peptidyl-lysine modification to hypusine; protein homotetramerization IPR002773; Protein modification; eIF5A hypusination. Deoxyhypusine synthase (DHS) (EC 2.5.1.46) Dhps Rattus norvegicus (Rat) TR39450_c0_g1_i1 Q9Y5W7 SNX14_HUMAN 2.00E-10 GO:0007154; GO:0016021; GO:0035091; GO:0015031; GO:0038032 cell communication; integral to membrane; phosphatidylinositol binding; protein transport; termination of G-protein coupled receptor signaling pathway IPR001683; IPR003114; IPR016137; IPR000342; IPR013937; Sorting nexin-14 SNX14 Homo sapiens (Human) TR39450_c0_g1_i2 Q7Z7A4 PXK_HUMAN 2.00E-48 GO:0007154; GO:0005813; GO:0005737; GO:0006954; GO:0032780; GO:0043271; GO:0005634; GO:0035091; GO:0005886; GO:0008022; GO:0050804; GO:0016772 "cell communication; centrosome; cytoplasm; inflammatory response; negative regulation of ATPase activity; negative regulation of ion transport; nucleus; phosphatidylinositol binding; plasma membrane; protein C-terminus binding; regulation of synaptic transmission; transferase activity, transferring phosphorus-containing groups" IPR011009; IPR001683; IPR000719; IPR028298; IPR003124; "PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA)" PXK Homo sapiens (Human) TR39450_c0_g2_i1 Q8BX57 PXK_MOUSE 2.00E-116 GO:0005524; GO:0007154; GO:0005813; GO:0005737; GO:0006954; GO:0032780; GO:0043271; GO:0005634; GO:0035091; GO:0005886; GO:0004672; GO:0050804 ATP binding; cell communication; centrosome; cytoplasm; inflammatory response; negative regulation of ATPase activity; negative regulation of ion transport; nucleus; phosphatidylinositol binding; plasma membrane; protein kinase activity; regulation of synaptic transmission IPR011009; IPR001683; IPR000719; IPR028298; IPR003124; "PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA)" Pxk Mus musculus (Mouse) TR39454_c2_g1_i1 P08120 CO4A1_DROME 6.00E-13 GO:0005587; GO:0007391; GO:0005201; GO:0035848 collagen type IV; dorsal closure; extracellular matrix structural constituent; oviduct morphogenesis IPR016187; IPR008160; IPR001442; Collagen alpha-1(IV) chain Cg25C DCg1 CG4145 Drosophila melanogaster (Fruit fly) TR39454_c3_g1_i2 P12107 COBA1_HUMAN 6.00E-49 GO:0001502; GO:0002063; GO:0030574; GO:0030199; GO:0005592; GO:0050910; GO:0048704; GO:0005788; GO:0050840; GO:0022617; GO:0005201; GO:0042472; GO:0046872; GO:0030674; GO:0006029; GO:0035989; GO:0055010; GO:0007601 "cartilage condensation; chondrocyte development; collagen catabolic process; collagen fibril organization; collagen type XI; detection of mechanical stimulus involved in sensory perception of sound; embryonic skeletal system morphogenesis; endoplasmic reticulum lumen; extracellular matrix binding; extracellular matrix disassembly; extracellular matrix structural constituent; inner ear morphogenesis; metal ion binding; protein binding, bridging; proteoglycan metabolic process; tendon development; ventricular cardiac muscle tissue morphogenesis; visual perception" IPR008160; IPR008985; IPR013320; IPR000885; IPR001791; Collagen alpha-1(XI) chain COL11A1 COLL6 Homo sapiens (Human) TR39454_c4_g1_i6 P02466 CO1A2_RAT 1.00E-06 GO:0071300; GO:0097067; GO:0005581; GO:0005201; GO:0005576; GO:0046872; GO:0071873 cellular response to retinoic acid; cellular response to thyroid hormone stimulus; collagen; extracellular matrix structural constituent; extracellular region; metal ion binding; response to norepinephrine stimulus IPR008160; IPR000885; Collagen alpha-2(I) chain (Alpha-2 type I collagen) Col1a2 Rattus norvegicus (Rat) TR39458_c8_g1_i1 P14902 I23O1_HUMAN 1.00E-36 GO:0007610; GO:0002534; GO:0005829; GO:0009055; GO:0007565; GO:0020037; GO:0033754; GO:0034276; GO:0046872; GO:0033555; GO:0070233; GO:0046007; GO:0032693; GO:0002666; GO:0043065; GO:0002678; GO:0032735; GO:0002830; GO:0032496; GO:0030485; GO:0032421; GO:0004833; GO:0006569; GO:0019441 "behavior; cytokine production involved in inflammatory response; cytosol; electron carrier activity; female pregnancy; heme binding; indoleamine 2,3-dioxygenase activity; kynurenic acid biosynthetic process; metal ion binding; multicellular organismal response to stress; negative regulation of T cell apoptotic process; negative regulation of activated T cell proliferation; negative regulation of interleukin-10 production; positive regulation of T cell tolerance induction; positive regulation of apoptotic process; positive regulation of chronic inflammatory response; positive regulation of interleukin-12 production; positive regulation of type 2 immune response; response to lipopolysaccharide; smooth muscle contractile fiber; stereocilium bundle; tryptophan 2,3-dioxygenase activity; tryptophan catabolic process; tryptophan catabolic process to kynurenine" IPR000898; Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. "Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase)" IDO1 IDO INDO Homo sapiens (Human) TR39458_c8_g3_i1 Q8R0V5 I23O2_MOUSE 5.00E-35 GO:0005737; GO:0020037; GO:0033754; GO:0046872; GO:0019441 "cytoplasm; heme binding; indoleamine 2,3-dioxygenase activity; metal ion binding; tryptophan catabolic process to kynurenine" IPR000898; Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. "Indoleamine 2,3-dioxygenase 2 (IDO-2) (EC 1.13.11.-) (Indoleamine 2,3-dioxygenase-like protein 1) (Indoleamine-pyrrole 2,3-dioxygenase-like protein 1)" Ido2 Indol1 Mus musculus (Mouse) TR39459_c0_g2_i1 Q5M9B1 SPSB3_XENLA 6.00E-25 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR001870; IPR008985; IPR001496; IPR003877; Protein modification; protein ubiquitination. SPRY domain-containing SOCS box protein 3 (SSB-3) spsb3 Xenopus laevis (African clawed frog) TR39459_c0_g2_i2 Q5E9X6 SPSB1_BOVIN 2.00E-19 GO:0005737; GO:0035556; GO:0016567 cytoplasm; intracellular signal transduction; protein ubiquitination IPR001870; IPR008985; IPR001496; IPR018355; IPR003877; Protein modification; protein ubiquitination. SPRY domain-containing SOCS box protein 1 (SSB-1) SPSB1 SSB1 Bos taurus (Bovine) TR39459_c0_g4_i2 A8QGZ7 FBSP1_BRUMA 3.00E-07 GO:0030054; GO:0016567; GO:0045202 cell junction; protein ubiquitination; synapse IPR001870; IPR008985; IPR001810; IPR018355; IPR003877; Protein modification; protein ubiquitination. F-box/SPRY domain-containing protein 1 (F-box synaptic protein 1) Bm1_56115 Brugia malayi (Filarial nematode worm) TR3946_c0_g1_i1 P12270 TPR_HUMAN 2.00E-10 GO:0005524; GO:0000189; GO:0006404; GO:0005975; GO:0051301; GO:0035457; GO:0003682; GO:0019221; GO:0005868; GO:0070840; GO:0019898; GO:0015758; GO:0031072; GO:0000776; GO:0003729; GO:0031990; GO:0051019; GO:0007067; GO:0007077; GO:0072686; GO:0007094; GO:0046832; GO:0000122; GO:0045947; GO:0042405; GO:0031965; GO:0034399; GO:0044615; GO:0006999; GO:0005487; GO:0005654; GO:0031453; GO:0090267; GO:0046827; GO:0042307; GO:0042803; GO:0010827; GO:0010965; GO:1901673; GO:0070849; GO:0004828; GO:0006434; GO:0044281; GO:0055085; GO:0015631; GO:0016032 ATP binding; MAPK import into nucleus; RNA import into nucleus; carbohydrate metabolic process; cell division; cellular response to interferon-alpha; chromatin binding; cytokine-mediated signaling pathway; cytoplasmic dynein complex; dynein complex binding; extrinsic to membrane; glucose transport; heat shock protein binding; kinetochore; mRNA binding; mRNA export from nucleus in response to heat stress; mitogen-activated protein kinase binding; mitosis; mitotic nuclear envelope disassembly; mitotic spindle; mitotic spindle assembly checkpoint; negative regulation of RNA export from nucleus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of translational initiation; nuclear inclusion body; nuclear membrane; nuclear periphery; nuclear pore nuclear basket; nuclear pore organization; nucleocytoplasmic transporter activity; nucleoplasm; positive regulation of heterochromatin assembly; positive regulation of mitotic cell cycle spindle assembly checkpoint; positive regulation of protein export from nucleus; positive regulation of protein import into nucleus; protein homodimerization activity; regulation of glucose transport; regulation of mitotic sister chromatid separation; regulation of spindle assembly involved in mitosis; response to epidermal growth factor stimulus; serine-tRNA ligase activity; seryl-tRNA aminoacylation; small molecule metabolic process; transmembrane transport; tubulin binding; viral process IPR015866; IPR012929; Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) TPR Homo sapiens (Human) TR39461_c1_g1_i3 Q5R9K8 AR2BP_PONAB 2.00E-52 GO:0005813; GO:0051457; GO:0030496; GO:0005758; GO:0005634; GO:0042517; GO:0005819; GO:0003713 centrosome; maintenance of protein location in nucleus; midbody; mitochondrial intermembrane space; nucleus; positive regulation of tyrosine phosphorylation of Stat3 protein; spindle; transcription coactivator activity IPR023379; ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) ARL2BP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39461_c1_g1_i7 Q9Y2Y0 AR2BP_HUMAN 1.00E-24 GO:0005813; GO:0051457; GO:0030496; GO:0005758; GO:0005634; GO:0042517; GO:0007165; GO:0005083; GO:0005819; GO:0003713 centrosome; maintenance of protein location in nucleus; midbody; mitochondrial intermembrane space; nucleus; positive regulation of tyrosine phosphorylation of Stat3 protein; signal transduction; small GTPase regulator activity; spindle; transcription coactivator activity IPR023379; ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) (Binder of ARF2 protein 1) ARL2BP BART BART1 Homo sapiens (Human) TR39464_c8_g4_i2 P85007 IR3IP_RAT 8.00E-28 GO:0005789; GO:0016021; GO:2000269 endoplasmic reticulum membrane; integral to membrane; regulation of fibroblast apoptotic process IPR013880; Immediate early response 3-interacting protein 1 Ier3ip1 Rattus norvegicus (Rat) TR39465_c1_g1_i1 Q960W6 FACR3_DROME 6.00E-103 GO:0080019; GO:0016021; GO:0006629; GO:0050062; GO:0005777; GO:0010025 fatty-acyl-CoA reductase (alcohol-forming) activity; integral to membrane; lipid metabolic process; long-chain-fatty-acyl-CoA reductase activity; peroxisome; wax biosynthetic process IPR026055; IPR013120; IPR016040; Putative fatty acyl-CoA reductase CG8306 (EC 1.2.1.n2) CG8306 Drosophila melanogaster (Fruit fly) TR39465_c1_g1_i2 Q922J9 FACR1_MOUSE 0 GO:0008611; GO:0080019; GO:0046474; GO:0016021; GO:0035336; GO:0050062; GO:0005778; GO:0005777; GO:0010025 ether lipid biosynthetic process; fatty-acyl-CoA reductase (alcohol-forming) activity; glycerophospholipid biosynthetic process; integral to membrane; long-chain fatty-acyl-CoA metabolic process; long-chain-fatty-acyl-CoA reductase activity; peroxisomal membrane; peroxisome; wax biosynthetic process IPR026055; IPR013120; IPR016040; Fatty acyl-CoA reductase 1 (EC 1.2.1.n2) (Male sterility domain-containing protein 2) Far1 Mlstd2 Mus musculus (Mouse) TR39465_c1_g1_i4 Q1PEI6 FACR8_ARATH 3.00E-44 GO:0080019; GO:0006629 fatty-acyl-CoA reductase (alcohol-forming) activity; lipid metabolic process IPR026055; IPR013120; IPR016040; Fatty acyl-CoA reductase 8 (EC 1.2.1.n2) FAR8 At3g44560 F14L2.110 Arabidopsis thaliana (Mouse-ear cress) TR39465_c1_g1_i5 Q922J9 FACR1_MOUSE 0 GO:0008611; GO:0080019; GO:0046474; GO:0016021; GO:0035336; GO:0050062; GO:0005778; GO:0005777; GO:0010025 ether lipid biosynthetic process; fatty-acyl-CoA reductase (alcohol-forming) activity; glycerophospholipid biosynthetic process; integral to membrane; long-chain fatty-acyl-CoA metabolic process; long-chain-fatty-acyl-CoA reductase activity; peroxisomal membrane; peroxisome; wax biosynthetic process IPR026055; IPR013120; IPR016040; Fatty acyl-CoA reductase 1 (EC 1.2.1.n2) (Male sterility domain-containing protein 2) Far1 Mlstd2 Mus musculus (Mouse) TR39467_c3_g5_i3 P82103 MYNA_MYTGA 6.00E-56 GO:0042742; GO:0005576 defense response to bacterium; extracellular region IPR019631; Myticin-A Mytilus galloprovincialis (Mediterranean mussel) TR39467_c3_g6_i1 P82102 MYNB_MYTGA 2.00E-54 GO:0042742; GO:0050832; GO:0005576; GO:0031640 defense response to bacterium; defense response to fungus; extracellular region; killing of cells of other organism IPR019631; Myticin-B Mytilus galloprovincialis (Mediterranean mussel) TR39468_c1_g1_i1 Q7M3S9 RNGB_DICDI 4.00E-23 GO:0005737; GO:0008270 cytoplasm; zinc ion binding IPR015915; IPR006652; IPR001841; IPR013083; RING finger protein B (Protein rngB) rngB DDB_G0268860 Dictyostelium discoideum (Slime mold) TR39468_c1_g1_i2 Q9Y5Z7 HCFC2_HUMAN 2.00E-09 GO:0005737; GO:0000122; GO:0005634; GO:0003713; GO:0016032 cytoplasm; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription coactivator activity; viral process IPR003961; IPR011043; IPR015916; IPR013783; IPR015915; Host cell factor 2 (HCF-2) (C2 factor) HCFC2 Homo sapiens (Human) TR39469_c3_g1_i1 A5D6U8 PAPL_DANRE 2.00E-62 GO:0003993; GO:0005576; GO:0046872 acid phosphatase activity; extracellular region; metal ion binding IPR004843; IPR008963; IPR015914; IPR025733; Iron/zinc purple acid phosphatase-like protein (EC 3.1.3.2) papl zgc:162913 Danio rerio (Zebrafish) (Brachydanio rerio) TR39470_c0_g3_i2 Q23435 TWK9_CAEEL 4.00E-09 GO:0016021; GO:0005267 integral to membrane; potassium channel activity IPR003280; IPR013099; TWiK family of potassium channels protein 9 twk-9 ZK1251.8 Caenorhabditis elegans TR39470_c0_g4_i1 Q6Q1P3 KCNKI_RAT 1.00E-18 GO:0015269; GO:0071467; GO:0016021; GO:0015271; GO:0005886; GO:0071435; GO:0006813 calcium-activated potassium channel activity; cellular response to pH; integral to membrane; outward rectifier potassium channel activity; plasma membrane; potassium ion export; potassium ion transport IPR003280; IPR013099; IPR003092; Potassium channel subfamily K member 18 (Tresk-2) (Two-pore-domain potassium channel TRESK) Kcnk18 Tresk-2 Tresk2 Rattus norvegicus (Rat) TR39471_c0_g1_i1 Q99459 CDC5L_HUMAN 1.00E-168 GO:0003677; GO:0000974; GO:0003723; GO:0071987; GO:0071013; GO:0007049; GO:0003682; GO:0005737; GO:0000398; GO:0016607; GO:0005730; GO:0006355; GO:0006351 Q13535; P52272; Q13416; O43660; Q9UMS4; Q15428 "DNA binding; Prp19 complex; RNA binding; WD40-repeat domain binding; catalytic step 2 spliceosome; cell cycle; chromatin binding; cytoplasm; mRNA splicing, via spliceosome; nuclear speck; nucleolus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR021786; IPR009057; IPR017930; IPR001005; Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) CDC5L KIAA0432 PCDC5RP Homo sapiens (Human) TR39473_c1_g2_i2 Q3KRG3 TSR2_DANRE 2.00E-33 GO:0006364 rRNA processing IPR019398; Pre-rRNA-processing protein TSR2 homolog tsr2 dt1p1a10l zgc:109784 Danio rerio (Zebrafish) (Brachydanio rerio) TR39474_c1_g1_i2 Q5ZKY2 ATG7_CHICK 0 GO:0019778; GO:0007628; GO:0006914; GO:0055013; GO:0006520; GO:0021955; GO:0021680; GO:0021987; GO:0001889; GO:0043066; GO:0050877; GO:0006996; GO:0016239; GO:0031401; GO:0009791; GO:0000407; GO:0030163; GO:0006497; GO:0032446; GO:0015031; GO:0021860; GO:0031396; GO:0042594; GO:0004839 APG12 activating enzyme activity; adult walking behavior; autophagy; cardiac muscle cell development; cellular amino acid metabolic process; central nervous system neuron axonogenesis; cerebellar Purkinje cell layer development; cerebral cortex development; liver development; negative regulation of apoptotic process; neurological system process; organelle organization; positive regulation of macroautophagy; positive regulation of protein modification process; post-embryonic development; pre-autophagosomal structure; protein catabolic process; protein lipidation; protein modification by small protein conjugation; protein transport; pyramidal neuron development; regulation of protein ubiquitination; response to starvation; ubiquitin activating enzyme activity IPR006285; IPR009036; IPR016040; IPR000594; Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) ATG7 APG7L RCJMB04_8l10 Gallus gallus (Chicken) TR39475_c0_g2_i1 Q98QE1 POTA_MYCPU 3.00E-06 GO:0005524; GO:0006200; GO:0043190; GO:0005886; GO:0015594; GO:0015595 ATP binding; ATP catabolic process; ATP-binding cassette (ABC) transporter complex; plasma membrane; putrescine-importing ATPase activity; spermidine-importing ATPase activity IPR003593; IPR017879; IPR003439; IPR017871; IPR008995; IPR027417; IPR013611; Spermidine/putrescine import ATP-binding protein PotA (EC 3.6.3.31) potA MYPU_4250 Mycoplasma pulmonis (strain UAB CTIP) TR39475_c0_g2_i2 Q9H172 ABCG4_HUMAN 1.00E-75 GO:0005524; GO:0006200; GO:0016887; GO:0033344; GO:0017127; GO:0016021; GO:0005886; GO:0042803; GO:0055085 P45844-4 ATP binding; ATP catabolic process; ATPase activity; cholesterol efflux; cholesterol transporter activity; integral to membrane; plasma membrane; protein homodimerization activity; transmembrane transport IPR003593; IPR013525; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family G member 4 ABCG4 WHITE2 Homo sapiens (Human) TR39475_c0_g3_i2 P45844 ABCG1_HUMAN 4.00E-164 GO:0043531; GO:0005524; GO:0005794; GO:0000139; GO:0042987; GO:0015485; GO:0033344; GO:0042632; GO:0008203; GO:0017127; GO:0009720; GO:0005789; GO:0009897; GO:0034436; GO:0034437; GO:0034375; GO:0005887; GO:0032367; GO:0042157; GO:0034374; GO:0005739; GO:0010887; GO:0010745; GO:0005543; GO:0033700; GO:0055091; GO:0005548; GO:0045542; GO:0010875; GO:0042803; GO:0055037; GO:0010872; GO:0006355; GO:0055099; GO:0033993; GO:0043691; GO:0034041; GO:0019534 Q9H172 "ADP binding; ATP binding; Golgi apparatus; Golgi membrane; amyloid precursor protein catabolic process; cholesterol binding; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transporter activity; detection of hormone stimulus; endoplasmic reticulum membrane; external side of plasma membrane; glycoprotein transport; glycoprotein transporter activity; high-density lipoprotein particle remodeling; integral to plasma membrane; intracellular cholesterol transport; lipoprotein metabolic process; low-density lipoprotein particle remodeling; mitochondrion; negative regulation of cholesterol storage; negative regulation of macrophage derived foam cell differentiation; phospholipid binding; phospholipid efflux; phospholipid homeostasis; phospholipid transporter activity; positive regulation of cholesterol biosynthetic process; positive regulation of cholesterol efflux; protein homodimerization activity; recycling endosome; regulation of cholesterol esterification; regulation of transcription, DNA-dependent; response to high density lipoprotein particle stimulus; response to lipid; reverse cholesterol transport; sterol-transporting ATPase activity; toxin transporter activity" IPR003593; IPR013525; IPR003439; IPR017871; IPR027417; IPR005284; ATP-binding cassette sub-family G member 1 (ATP-binding cassette transporter 8) (White protein homolog) ABCG1 ABC8 WHT1 Homo sapiens (Human) TR39475_c0_g3_i3 Q9H172 ABCG4_HUMAN 4.00E-151 GO:0005524; GO:0006200; GO:0016887; GO:0033344; GO:0017127; GO:0016021; GO:0005886; GO:0042803; GO:0055085 P45844-4 ATP binding; ATP catabolic process; ATPase activity; cholesterol efflux; cholesterol transporter activity; integral to membrane; plasma membrane; protein homodimerization activity; transmembrane transport IPR003593; IPR013525; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family G member 4 ABCG4 WHITE2 Homo sapiens (Human) TR39475_c1_g1_i1 P04323 POL3_DROME 4.00E-11 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR39476_c0_g1_i1 A8WHP3 SC5A9_DANRE 0 GO:0016021; GO:0006814; GO:0055085; GO:0005215 integral to membrane; sodium ion transport; transmembrane transport; transporter activity IPR001734; IPR018212; IPR019900; Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (Solute carrier family 5 member 9) slc5a9 si:dkey-7o6.5 Danio rerio (Zebrafish) (Brachydanio rerio) TR39477_c0_g1_i1 Q9XIW0 CIPK7_ARATH 2.00E-52 GO:0005524; GO:0004674; GO:0009409; GO:0007165 O81445 ATP binding; protein serine/threonine kinase activity; response to cold; signal transduction IPR011009; IPR018451; IPR004041; IPR000719; IPR017441; IPR002290; IPR008271; CBL-interacting serine/threonine-protein kinase 7 (EC 2.7.11.1) (SNF1-related kinase 3.10) (SOS2-like protein kinase PKS7) (Serine/threonine-protein kinase SR2) (AtSR2) (AtSRPK1) CIPK7 PKS7 SnRK3.10 SR2 SRPK1 At3g23000 MXC7.3 Arabidopsis thaliana (Mouse-ear cress) TR39477_c0_g1_i10 Q6P6U0 FGR_RAT 4.00E-13 GO:0005524; GO:0015629; GO:0005829; GO:0050830; GO:0034987; GO:0045087; GO:0007229; GO:0005743; GO:0005758; GO:0004715; GO:0001784; GO:0005886; GO:0030335; GO:0050715; GO:0043306; GO:0043552; GO:0014068; GO:0046777; GO:0019901; GO:0004713; GO:0008360; GO:0045088; GO:0050764; GO:0045859; GO:0032587 ATP binding; actin cytoskeleton; cytosol; defense response to Gram-positive bacterium; immunoglobulin receptor binding; innate immune response; integrin-mediated signaling pathway; mitochondrial inner membrane; mitochondrial intermembrane space; non-membrane spanning protein tyrosine kinase activity; phosphotyrosine binding; plasma membrane; positive regulation of cell migration; positive regulation of cytokine secretion; positive regulation of mast cell degranulation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase cascade; protein autophosphorylation; protein kinase binding; protein tyrosine kinase activity; regulation of cell shape; regulation of innate immune response; regulation of phagocytosis; regulation of protein kinase activity; ruffle membrane IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Proto-oncogene c-Fgr) (p55-Fgr) Fgr Rattus norvegicus (Rat) TR39477_c0_g1_i11 Q9C562 CIPKA_ARATH 5.00E-50 GO:0005524; GO:0004674; GO:0007165 ATP binding; protein serine/threonine kinase activity; signal transduction IPR020636; IPR011009; IPR018451; IPR004041; IPR000719; IPR017441; IPR002290; IPR008271; CBL-interacting serine/threonine-protein kinase 10 (EC 2.7.11.1) (SNF1-related kinase 3.8) (SOS2-like protein kinase PKS2) (SOS3-interacting protein 1) CIPK10 PKS2 SIP1 SnRK3.8 At5g58380 MCK7.25 Arabidopsis thaliana (Mouse-ear cress) TR39477_c0_g1_i12 Q9XIW0 CIPK7_ARATH 3.00E-52 GO:0005524; GO:0004674; GO:0009409; GO:0007165 O81445 ATP binding; protein serine/threonine kinase activity; response to cold; signal transduction IPR011009; IPR018451; IPR004041; IPR000719; IPR017441; IPR002290; IPR008271; CBL-interacting serine/threonine-protein kinase 7 (EC 2.7.11.1) (SNF1-related kinase 3.10) (SOS2-like protein kinase PKS7) (Serine/threonine-protein kinase SR2) (AtSR2) (AtSRPK1) CIPK7 PKS7 SnRK3.10 SR2 SRPK1 At3g23000 MXC7.3 Arabidopsis thaliana (Mouse-ear cress) TR39477_c0_g1_i13 P23572 CDK1_DROME 7.00E-30 GO:0005524; GO:0000082; GO:0000086; GO:0008353; GO:0055059; GO:0004693; GO:0048142; GO:0007141; GO:0008315; GO:0005875; GO:0007067; GO:0005634; GO:0032880; GO:0006974; GO:0007284 Q9VHN1; Q9I7I0; P25008; P54733; Q961D1; Q03019 ATP binding; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; RNA polymerase II carboxy-terminal domain kinase activity; asymmetric neuroblast division; cyclin-dependent protein serine/threonine kinase activity; germarium-derived cystoblast division; male meiosis I; meiotic G2/MI transition; microtubule associated complex; mitosis; nucleus; regulation of protein localization; response to DNA damage stimulus; spermatogonial cell division IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) cdc2 cdk1 CG5363 Drosophila melanogaster (Fruit fly) TR39477_c0_g1_i14 O14965 AURKA_HUMAN 1.00E-142 GO:0005524; GO:0031145; GO:0051301; GO:0030030; GO:0005829; GO:0030496; GO:0007067; GO:0032091; GO:0005634; GO:0048471; GO:0048015; GO:0045840; GO:0046777; GO:0004674; GO:0004712; GO:0046605; GO:0031647; GO:0005876; GO:0007051; GO:0031616; GO:0043146 Q9NWT8; P61978; P04198; Q8VDQ8; O15350 ATP binding; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; cell projection organization; cytosol; midbody; mitosis; negative regulation of protein binding; nucleus; perinuclear region of cytoplasm; phosphatidylinositol-mediated signaling; positive regulation of mitosis; protein autophosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; regulation of centrosome cycle; regulation of protein stability; spindle microtubule; spindle organization; spindle pole centrosome; spindle stabilization IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A) AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6 Homo sapiens (Human) TR39477_c0_g1_i2 Q6BNF3 STE20_DEBHA 2.00E-22 GO:0005524; GO:0005737; GO:0005634; GO:0004674; GO:0019236 ATP binding; cytoplasm; nucleus; protein serine/threonine kinase activity; response to pheromone IPR000095; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase STE20 (EC 2.7.11.1) STE20 DEHA2E22220g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR39477_c0_g1_i3 P23572 CDK1_DROME 1.00E-29 GO:0005524; GO:0000082; GO:0000086; GO:0008353; GO:0055059; GO:0004693; GO:0048142; GO:0007141; GO:0008315; GO:0005875; GO:0007067; GO:0005634; GO:0032880; GO:0006974; GO:0007284 Q9VHN1; Q9I7I0; P25008; P54733; Q961D1; Q03019 ATP binding; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; RNA polymerase II carboxy-terminal domain kinase activity; asymmetric neuroblast division; cyclin-dependent protein serine/threonine kinase activity; germarium-derived cystoblast division; male meiosis I; meiotic G2/MI transition; microtubule associated complex; mitosis; nucleus; regulation of protein localization; response to DNA damage stimulus; spermatogonial cell division IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) cdc2 cdk1 CG5363 Drosophila melanogaster (Fruit fly) TR39477_c0_g1_i4 O14965 AURKA_HUMAN 2.00E-142 GO:0005524; GO:0031145; GO:0051301; GO:0030030; GO:0005829; GO:0030496; GO:0007067; GO:0032091; GO:0005634; GO:0048471; GO:0048015; GO:0045840; GO:0046777; GO:0004674; GO:0004712; GO:0046605; GO:0031647; GO:0005876; GO:0007051; GO:0031616; GO:0043146 Q9NWT8; P61978; P04198; Q8VDQ8; O15350 ATP binding; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; cell projection organization; cytosol; midbody; mitosis; negative regulation of protein binding; nucleus; perinuclear region of cytoplasm; phosphatidylinositol-mediated signaling; positive regulation of mitosis; protein autophosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; regulation of centrosome cycle; regulation of protein stability; spindle microtubule; spindle organization; spindle pole centrosome; spindle stabilization IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A) AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6 Homo sapiens (Human) TR39477_c0_g1_i5 Q6P6U0 FGR_RAT 4.00E-13 GO:0005524; GO:0015629; GO:0005829; GO:0050830; GO:0034987; GO:0045087; GO:0007229; GO:0005743; GO:0005758; GO:0004715; GO:0001784; GO:0005886; GO:0030335; GO:0050715; GO:0043306; GO:0043552; GO:0014068; GO:0046777; GO:0019901; GO:0004713; GO:0008360; GO:0045088; GO:0050764; GO:0045859; GO:0032587 ATP binding; actin cytoskeleton; cytosol; defense response to Gram-positive bacterium; immunoglobulin receptor binding; innate immune response; integrin-mediated signaling pathway; mitochondrial inner membrane; mitochondrial intermembrane space; non-membrane spanning protein tyrosine kinase activity; phosphotyrosine binding; plasma membrane; positive regulation of cell migration; positive regulation of cytokine secretion; positive regulation of mast cell degranulation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase cascade; protein autophosphorylation; protein kinase binding; protein tyrosine kinase activity; regulation of cell shape; regulation of innate immune response; regulation of phagocytosis; regulation of protein kinase activity; ruffle membrane IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Proto-oncogene c-Fgr) (p55-Fgr) Fgr Rattus norvegicus (Rat) TR39477_c0_g1_i6 P34112 CDK1_DICDI 9.00E-33 GO:0005524; GO:0008353; GO:0051301; GO:0004693; GO:0005622; GO:0007067 ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; cell division; cyclin-dependent protein serine/threonine kinase activity; intracellular; mitosis IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) cdk1 cdcB DDB_G0272813 Dictyostelium discoideum (Slime mold) TR39477_c0_g1_i7 Q9XIW0 CIPK7_ARATH 9.00E-53 GO:0005524; GO:0004674; GO:0009409; GO:0007165 O81445 ATP binding; protein serine/threonine kinase activity; response to cold; signal transduction IPR011009; IPR018451; IPR004041; IPR000719; IPR017441; IPR002290; IPR008271; CBL-interacting serine/threonine-protein kinase 7 (EC 2.7.11.1) (SNF1-related kinase 3.10) (SOS2-like protein kinase PKS7) (Serine/threonine-protein kinase SR2) (AtSR2) (AtSRPK1) CIPK7 PKS7 SnRK3.10 SR2 SRPK1 At3g23000 MXC7.3 Arabidopsis thaliana (Mouse-ear cress) TR39477_c0_g1_i8 Q6BNF3 STE20_DEBHA 5.00E-23 GO:0005524; GO:0005737; GO:0005634; GO:0004674; GO:0019236 ATP binding; cytoplasm; nucleus; protein serine/threonine kinase activity; response to pheromone IPR000095; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase STE20 (EC 2.7.11.1) STE20 DEHA2E22220g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR39477_c0_g1_i9 O14965 AURKA_HUMAN 3.00E-146 GO:0005524; GO:0031145; GO:0051301; GO:0030030; GO:0005829; GO:0030496; GO:0007067; GO:0032091; GO:0005634; GO:0048471; GO:0048015; GO:0045840; GO:0046777; GO:0004674; GO:0004712; GO:0046605; GO:0031647; GO:0005876; GO:0007051; GO:0031616; GO:0043146 Q9NWT8; P61978; P04198; Q8VDQ8; O15350 ATP binding; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; cell projection organization; cytosol; midbody; mitosis; negative regulation of protein binding; nucleus; perinuclear region of cytoplasm; phosphatidylinositol-mediated signaling; positive regulation of mitosis; protein autophosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; regulation of centrosome cycle; regulation of protein stability; spindle microtubule; spindle organization; spindle pole centrosome; spindle stabilization IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A) AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6 Homo sapiens (Human) TR39479_c3_g1_i2 Q60542 ZEB1_MESAU 7.00E-39 GO:0070888; GO:0046872; GO:0045892; GO:0005634; GO:0045666; GO:0043565; GO:0003700; GO:0006351 "E-box binding; metal ion binding; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of neuron differentiation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008598; IPR001356; IPR009057; IPR007087; IPR015880; IPR013087; Zinc finger E-box-binding homeobox 1 (Transcription factor 8) (TCF-8) (Zinc finger protein BZP) ZEB1 BZP TCF8 Mesocricetus auratus (Golden hamster) TR39479_c3_g1_i3 G5EBU4 ZAG1_CAEEL 7.00E-44 GO:0007411; GO:0046872; GO:0000122; GO:0005634; GO:0045773; GO:0043565; GO:0003700; GO:0006351 "axon guidance; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of axon extension; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; IPR007087; IPR015880; IPR013087; Zinc finger E-box-binding homeobox protein zag-1 (Zinc finger involved in axon guidance 1) (ZAG-1) zag-1 F28F9.1 Caenorhabditis elegans TR39480_c5_g1_i1 Q5ZLA6 MYO1C_CHICK 0 GO:0005524; GO:0005737; GO:0003774; GO:0016459; GO:0060171 ATP binding; cytoplasm; motor activity; myosin complex; stereocilium membrane IPR000048; IPR001609; IPR010926; IPR027417; Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) MYO1C RCJMB04_6o17 Gallus gallus (Chicken) TR39480_c5_g2_i1 Q28970 MYO7A_PIG 4.00E-19 GO:0005524; GO:0005938; GO:0003774; GO:0016459; GO:0007605 ATP binding; cell cortex; motor activity; myosin complex; sensory perception of sound IPR001609; IPR027417; Unconventional myosin-VIIa (Fragment) MYO7A Sus scrofa (Pig) TR39481_c3_g1_i1 Q0PV50 TLR3_BOSTR 6.00E-51 GO:0002756; GO:0051607; GO:0003725; GO:0005789; GO:0010008; GO:0006954; GO:0045087; GO:0016021; GO:0032722; GO:0050729; GO:0043330; GO:0034138; GO:0004888 MyD88-independent toll-like receptor signaling pathway; defense response to virus; double-stranded RNA binding; endoplasmic reticulum membrane; endosome membrane; inflammatory response; innate immune response; integral to membrane; positive regulation of chemokine production; positive regulation of inflammatory response; response to exogenous dsRNA; toll-like receptor 3 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; IPR027173; Toll-like receptor 3 (CD antigen CD283) TLR3 Boselaphus tragocamelus (Nilgai) TR39481_c3_g1_i2 Q6UXM1 LRIG3_HUMAN 8.00E-29 GO:0030659; GO:0016021; GO:0007275; GO:0005886 cytoplasmic vesicle membrane; integral to membrane; multicellular organismal development; plasma membrane IPR000483; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR001611; IPR025875; IPR003591; IPR000372; Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) LRIG3 LIG3 UNQ287/PRO326/PRO335 Homo sapiens (Human) TR39481_c3_g1_i3 Q9XSD9 PGS2_PIG 3.00E-19 GO:0005578 proteinaceous extracellular matrix IPR001611; IPR003591; IPR000372; IPR016352; Decorin (Bone proteoglycan II) (PG-S2) DCN Sus scrofa (Pig) TR39481_c3_g1_i4 Q0PV50 TLR3_BOSTR 4.00E-50 GO:0002756; GO:0051607; GO:0003725; GO:0005789; GO:0010008; GO:0006954; GO:0045087; GO:0016021; GO:0032722; GO:0050729; GO:0043330; GO:0034138; GO:0004888 MyD88-independent toll-like receptor signaling pathway; defense response to virus; double-stranded RNA binding; endoplasmic reticulum membrane; endosome membrane; inflammatory response; innate immune response; integral to membrane; positive regulation of chemokine production; positive regulation of inflammatory response; response to exogenous dsRNA; toll-like receptor 3 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; IPR027173; Toll-like receptor 3 (CD antigen CD283) TLR3 Boselaphus tragocamelus (Nilgai) TR39483_c0_g1_i1 Q18610 YYC5_CAEEL 8.00E-67 GO:0004091 carboxylesterase activity IPR012020; IPR000952; Putative esterase C44C1.5 (EC 3.1.1.-) C44C1.5 Caenorhabditis elegans TR39483_c0_g1_i3 Q8WU67 ABHD3_HUMAN 7.00E-122 GO:0004091; GO:0016021 carboxylesterase activity; integral to membrane IPR012020; IPR000952; Abhydrolase domain-containing protein 3 (EC 3.1.1.-) (Lung alpha/beta hydrolase 3) ABHD3 LABH3 Homo sapiens (Human) TR39485_c0_g1_i1 P16332 MUTA_MOUSE 0 GO:0031419; GO:0050667; GO:0046872; GO:0004494; GO:0005759; GO:0005739; GO:0072341; GO:0009791 cobalamin binding; homocysteine metabolic process; metal ion binding; methylmalonyl-CoA mutase activity; mitochondrial matrix; mitochondrion; modified amino acid binding; post-embryonic development IPR006159; IPR016176; IPR014348; IPR006158; IPR006099; IPR006098; "Methylmalonyl-CoA mutase, mitochondrial (MCM) (EC 5.4.99.2) (Methylmalonyl-CoA isomerase)" Mut Mus musculus (Mouse) TR39485_c0_g1_i2 P11652 MUTA_PROFR 3.00E-30 GO:0031419; GO:0019652; GO:0046872; GO:0004494 P11653 cobalamin binding; lactate fermentation to propionate and acetate; metal ion binding; methylmalonyl-CoA mutase activity IPR016176; IPR014348; IPR006158; IPR024067; IPR006099; IPR004608; Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 3/3. Methylmalonyl-CoA mutase small subunit (EC 5.4.99.2) (MCB-beta) mutA Propionibacterium freudenreichii subsp. shermanii TR39487_c0_g1_i3 Q6GN98 N6MT2_XENLA 4.00E-75 GO:0008168; GO:0003676 methyltransferase activity; nucleic acid binding IPR002052; IPR019369; N(6)-adenine-specific DNA methyltransferase 2 (EC 2.1.1.-) n6amt2 Xenopus laevis (African clawed frog) TR39488_c2_g1_i1 O75665 OFD1_HUMAN 9.00E-44 GO:0000086; GO:0043014; GO:0005814; GO:0005929; GO:0035083; GO:0060271; GO:0005829; GO:0060287; GO:0043015; GO:0005932; GO:0005634 P53350 G2/M transition of mitotic cell cycle; alpha-tubulin binding; centriole; cilium; cilium axoneme assembly; cilium morphogenesis; cytosol; epithelial cilium movement involved in determination of left/right asymmetry; gamma-tubulin binding; microtubule basal body; nucleus IPR006594; Oral-facial-digital syndrome 1 protein (Protein 71-7A) OFD1 CXorf5 Homo sapiens (Human) TR39488_c3_g1_i1 Q0P651 CD029_HUMAN 1.00E-140 GO:0005576 extracellular region IPR019149; Uncharacterized protein C4orf29 C4orf29 Homo sapiens (Human) TR39488_c3_g1_i6 Q8C1A9 CD029_MOUSE 3.00E-162 GO:0005576 extracellular region IPR019149; Uncharacterized protein C4orf29 homolog Mus musculus (Mouse) TR39489_c3_g1_i1 P0C6B8 SVEP1_RAT 2.00E-56 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) TR39489_c3_g1_i2 Q4LDE5 SVEP1_HUMAN 1.00E-56 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) TR39489_c3_g1_i6 Q4LDE5 SVEP1_HUMAN 3.00E-11 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) TR39490_c3_g1_i1 P48480 PP11_ACECL 1.00E-52 GO:0046872; GO:0004721 metal ion binding; phosphoprotein phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1 isozyme 1 (EC 3.1.3.16) Acetabularia peniculus (Green alga) (Polyphysa peniculus) TR39490_c3_g1_i2 P48480 PP11_ACECL 7.00E-52 GO:0046872; GO:0004721 metal ion binding; phosphoprotein phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1 isozyme 1 (EC 3.1.3.16) Acetabularia peniculus (Green alga) (Polyphysa peniculus) TR39493_c0_g1_i1 Q704V6 TLR6_BOVIN 1.00E-06 GO:0002755; GO:0042088; GO:0042496; GO:0006954; GO:0045087; GO:0016021; GO:0030670; GO:0005886; GO:0045410; GO:0050707; GO:0034150; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; T-helper 1 type immune response; detection of diacyl bacterial lipopeptide; inflammatory response; innate immune response; integral to membrane; phagocytic vesicle membrane; plasma membrane; positive regulation of interleukin-6 biosynthetic process; regulation of cytokine secretion; toll-like receptor 6 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR000157; IPR027187; IPR017241; Toll-like receptor 6 (CD antigen CD286) TLR6 Bos taurus (Bovine) TR39493_c0_g1_i10 Q704V6 TLR6_BOVIN 3.00E-07 GO:0002755; GO:0042088; GO:0042496; GO:0006954; GO:0045087; GO:0016021; GO:0030670; GO:0005886; GO:0045410; GO:0050707; GO:0034150; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; T-helper 1 type immune response; detection of diacyl bacterial lipopeptide; inflammatory response; innate immune response; integral to membrane; phagocytic vesicle membrane; plasma membrane; positive regulation of interleukin-6 biosynthetic process; regulation of cytokine secretion; toll-like receptor 6 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR000157; IPR027187; IPR017241; Toll-like receptor 6 (CD antigen CD286) TLR6 Bos taurus (Bovine) TR39493_c0_g1_i7 Q9EPQ1 TLR1_MOUSE 2.00E-06 GO:0002755; GO:0035354; GO:0007250; GO:0071727; GO:0006952; GO:0042495; GO:0006954; GO:0045087; GO:0016021; GO:0042116; GO:0016020; GO:0045335; GO:0030670; GO:0045410; GO:0042535; GO:0050707; GO:0034130; GO:0004888; GO:0042497 MyD88-dependent toll-like receptor signaling pathway; Toll-like receptor 1-Toll-like receptor 2 protein complex; activation of NF-kappaB-inducing kinase activity; cellular response to triacyl bacterial lipopeptide; defense response; detection of triacyl bacterial lipopeptide; inflammatory response; innate immune response; integral to membrane; macrophage activation; membrane; phagocytic vesicle; phagocytic vesicle membrane; positive regulation of interleukin-6 biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; regulation of cytokine secretion; toll-like receptor 1 signaling pathway; transmembrane signaling receptor activity; triacyl lipopeptide binding IPR000483; IPR001611; IPR025875; IPR000157; IPR027190; IPR017241; Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) Tlr1 Mus musculus (Mouse) TR39493_c0_g1_i9 Q689D1 TLR2_CANFA 7.00E-07 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Canis familiaris (Dog) (Canis lupus familiaris) TR39495_c0_g1_i1 Q5E936 TXD12_BOVIN 1.00E-36 GO:0045454; GO:0005788; GO:0019153 cell redox homeostasis; endoplasmic reticulum lumen; protein-disulfide reductase (glutathione) activity IPR012336; IPR017937; Thioredoxin domain-containing protein 12 (EC 1.8.4.2) TXNDC12 Bos taurus (Bovine) TR39495_c0_g1_i7 Q5E936 TXD12_BOVIN 1.00E-36 GO:0045454; GO:0005788; GO:0019153 cell redox homeostasis; endoplasmic reticulum lumen; protein-disulfide reductase (glutathione) activity IPR012336; IPR017937; Thioredoxin domain-containing protein 12 (EC 1.8.4.2) TXNDC12 Bos taurus (Bovine) TR39496_c0_g1_i1 Q503M4 MT12B_DANRE 1.00E-41 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12-B (MCT 12-B) (Solute carrier family 16 member 12-B) slc16a12b slc16a12 zgc:110441 Danio rerio (Zebrafish) (Brachydanio rerio) TR39496_c0_g1_i3 P53918 ESBP6_YEAST 9.00E-16 GO:0005789; GO:0016021; GO:0016020; GO:0005739; GO:0015293; GO:0005215 P25376; P08456; P41543; P40975; P87284; P32368; P39986 endoplasmic reticulum membrane; integral to membrane; membrane; mitochondrion; symporter activity; transporter activity IPR011701; IPR016196; Uncharacterized transporter ESBP6 ESBP6 MCH3 YNL125C N1223 N1882 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39496_c0_g1_i4 Q8K1C7 MOT14_MOUSE 1.00E-47 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) Slc16a14 Mct14 Mus musculus (Mouse) TR39499_c1_g1_i1 Q8N8C0 ZN781_HUMAN 1.00E-24 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 781 ZNF781 Homo sapiens (Human) TR39499_c1_g1_i2 Q9NYT6 ZN226_HUMAN 8.00E-60 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 226 ZNF226 Homo sapiens (Human) TR39499_c1_g1_i3 A2VDP4 ZN567_BOVIN 2.00E-54 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 567 ZNF567 Bos taurus (Bovine) TR39499_c1_g1_i4 Q9NYT6 ZN226_HUMAN 7.00E-59 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 226 ZNF226 Homo sapiens (Human) TR39500_c2_g1_i1 Q6NYL3 ECHP_DANRE 0 GO:0003857; GO:0050662; GO:0004165; GO:0004300; GO:0006635; GO:0005777 3-hydroxyacyl-CoA dehydrogenase activity; coenzyme binding; dodecenoyl-CoA delta-isomerase activity; enoyl-CoA hydratase activity; fatty acid beta-oxidation; peroxisome IPR006180; IPR006176; IPR006108; IPR008927; IPR001753; IPR013328; IPR018376; IPR016040; Lipid metabolism; fatty acid beta-oxidation. "Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase (EC 4.2.1.17) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)]" ehhadh echd si:dkeyp-30d5.2 zgc:77526 Danio rerio (Zebrafish) (Brachydanio rerio) TR39500_c2_g1_i2 Q6NYL3 ECHP_DANRE 0 GO:0003857; GO:0050662; GO:0004165; GO:0004300; GO:0006635; GO:0005777 3-hydroxyacyl-CoA dehydrogenase activity; coenzyme binding; dodecenoyl-CoA delta-isomerase activity; enoyl-CoA hydratase activity; fatty acid beta-oxidation; peroxisome IPR006180; IPR006176; IPR006108; IPR008927; IPR001753; IPR013328; IPR018376; IPR016040; Lipid metabolism; fatty acid beta-oxidation. "Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase (EC 4.2.1.17) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)]" ehhadh echd si:dkeyp-30d5.2 zgc:77526 Danio rerio (Zebrafish) (Brachydanio rerio) TR39500_c2_g1_i4 P52041 HBD_CLOAB 1.00E-54 GO:0003857; GO:0008691; GO:0070403; GO:0019605 3-hydroxyacyl-CoA dehydrogenase activity; 3-hydroxybutyryl-CoA dehydrogenase activity; NAD+ binding; butyrate metabolic process IPR022694; IPR006180; IPR006176; IPR006108; IPR008927; IPR013328; IPR016040; Lipid metabolism; butanoate metabolism. 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157) (Beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) hbd CA_C2708 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) TR39500_c2_g1_i5 P41938 HCDH2_CAEEL 3.00E-45 GO:0003857; GO:0070403; GO:0006635; GO:0005759 3-hydroxyacyl-CoA dehydrogenase activity; NAD+ binding; fatty acid beta-oxidation; mitochondrial matrix IPR022694; IPR006180; IPR006176; IPR006108; IPR008927; IPR013328; IPR016040; Lipid metabolism; fatty acid beta-oxidation. Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3 (EC 1.1.1.35) B0272.3 Caenorhabditis elegans TR39501_c1_g1_i1 P34886 MEC10_CAEEL 2.00E-22 GO:0016021; GO:0015280; GO:0007638; GO:0005886 integral to membrane; ligand-gated sodium channel activity; mechanosensory behavior; plasma membrane IPR004726; IPR001873; IPR020903; Degenerin mec-10 (Mechanosensory abnormality protein 10) mec-10 F16F9.5 Caenorhabditis elegans TR39501_c1_g1_i2 Q25011 FANA_HELAS 1.00E-137 GO:0016021; GO:0005272; GO:0035725 integral to membrane; sodium channel activity; sodium ion transmembrane transport IPR001873; IPR020903; FMRFamide-activated amiloride-sensitive sodium channel (FANACH) Helix aspersa (Brown garden snail) (Cornu aspersum) TR39502_c0_g1_i2 Q5ZLF0 F10A1_CHICK 9.00E-54 GO:0005737 cytoplasm IPR006636; IPR013026; IPR011990; IPR013105; IPR019734; Hsc70-interacting protein (Hip) (Protein FAM10A1) (Protein ST13 homolog) ST13 FAM10A1 RCJMB04_6h13 Gallus gallus (Chicken) TR39502_c1_g2_i3 Q9FMD5 TIC40_ARATH 4.00E-06 GO:0031897; GO:0009658; GO:0009535; GO:0016021; GO:0045037 Q8LPR9 Tic complex; chloroplast organization; chloroplast thylakoid membrane; integral to membrane; protein import into chloroplast stroma IPR006636; "Protein TIC 40, chloroplastic (Protein PIGMENT DEFECTIVE EMBRYO 120) (Translocon at the inner envelope membrane of chloroplasts 40) (AtTIC40)" TIC40 PDE120 At5g16620 MTG13.6 Arabidopsis thaliana (Mouse-ear cress) TR39502_c1_g2_i6 Q5ZLF0 F10A1_CHICK 5.00E-18 GO:0005737 cytoplasm IPR006636; IPR013026; IPR011990; IPR013105; IPR019734; Hsc70-interacting protein (Hip) (Protein FAM10A1) (Protein ST13 homolog) ST13 FAM10A1 RCJMB04_6h13 Gallus gallus (Chicken) TR39503_c4_g1_i1 P54985 PPIA_BLAGE 1.00E-78 GO:0005737; GO:0042277; GO:0003755; GO:0006457; GO:0000413 cytoplasm; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Cyclophilin) (Cyclosporin A-binding protein) (Rotamase) CYPA Blattella germanica (German cockroach) (Blatta germanica) TR39504_c0_g1_i2 P38657 PDIA3_BOVIN 2.00E-159 GO:0045454; GO:0005783; GO:0005788; GO:0006662; GO:0042470; GO:0043065; GO:0003756; GO:0015035; GO:0006457 cell redox homeostasis; endoplasmic reticulum; endoplasmic reticulum lumen; glycerol ether metabolic process; melanosome; positive regulation of apoptotic process; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; protein folding IPR005788; IPR005792; IPR005746; IPR012336; IPR017937; IPR013766; Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) PDIA3 GRP58 Bos taurus (Bovine) TR39504_c0_g1_i4 Q8K2W3 TXD11_MOUSE 3.00E-06 GO:0045454; GO:0005789; GO:0016021 cell redox homeostasis; endoplasmic reticulum membrane; integral to membrane IPR012336; IPR013766; Thioredoxin domain-containing protein 11 Txndc11 Mus musculus (Mouse) TR39505_c3_g1_i2 Q99PL6 UBXN6_MOUSE 3.00E-89 GO:0005737; GO:0005815; GO:0005730 cytoplasm; microtubule organizing center; nucleolus IPR018997; IPR001012; UBX domain-containing protein 6 (UBX domain-containing protein 1) Ubxn6 Ubxd1 Ubxdc2 Mus musculus (Mouse) TR39507_c0_g2_i1 Q54ET2 PSNA_DICDI 8.00E-39 GO:0000139; GO:0007219; GO:0004190; GO:0004175; GO:0005789; GO:0005887; GO:0006508 Golgi membrane; Notch signaling pathway; aspartic-type endopeptidase activity; endopeptidase activity; endoplasmic reticulum membrane; integral to plasma membrane; proteolysis IPR001108; IPR006639; Presenilin-A (PS-A) (EC 3.4.23.-) psenA DDB_G0291352 Dictyostelium discoideum (Slime mold) TR39507_c0_g2_i2 Q0MS45 PSN2_PIG 7.00E-104 GO:0000139; GO:0007219; GO:0002286; GO:0050852; GO:0030018; GO:0042640; GO:0006915; GO:0004190; GO:0050435; GO:0048854; GO:0006816; GO:0060048; GO:0001708; GO:0044267; GO:0005813; GO:0005829; GO:0021904; GO:0030326; GO:0032469; GO:0005789; GO:0030900; GO:0002244; GO:0005887; GO:0035556; GO:0000776; GO:0040011; GO:0048286; GO:0006509; GO:0007613; GO:0002573; GO:0043066; GO:0001933; GO:0043025; GO:0005637; GO:0043065; GO:0043085; GO:0050820; GO:0016485; GO:0015031; GO:0007176; GO:0043393; GO:0048167; GO:0001756; GO:0048538 Golgi membrane; Notch signaling pathway; T cell activation involved in immune response; T cell receptor signaling pathway; Z disc; anagen; apoptotic process; aspartic-type endopeptidase activity; beta-amyloid metabolic process; brain morphogenesis; calcium ion transport; cardiac muscle contraction; cell fate specification; cellular protein metabolic process; centrosome; cytosol; dorsal/ventral neural tube patterning; embryonic limb morphogenesis; endoplasmic reticulum calcium ion homeostasis; endoplasmic reticulum membrane; forebrain development; hematopoietic progenitor cell differentiation; integral to plasma membrane; intracellular signal transduction; kinetochore; locomotion; lung alveolus development; membrane protein ectodomain proteolysis; memory; myeloid leukocyte differentiation; negative regulation of apoptotic process; negative regulation of protein phosphorylation; neuronal cell body; nuclear inner membrane; positive regulation of apoptotic process; positive regulation of catalytic activity; positive regulation of coagulation; protein processing; protein transport; regulation of epidermal growth factor-activated receptor activity; regulation of protein binding; regulation of synaptic plasticity; somitogenesis; thymus development IPR001493; IPR001108; IPR006639; Presenilin-2 (PS-2) (EC 3.4.23.-) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] PSEN2 Sus scrofa (Pig) TR39507_c0_g2_i4 P49769 PSN1_MOUSE 2.00E-114 GO:0021870; GO:0005794; GO:0000139; GO:0015813; GO:0007220; GO:0007219; GO:0002286; GO:0050852; GO:0030018; GO:0000186; GO:0042640; GO:0016324; GO:0004190; GO:0000045; GO:0030424; GO:0034205; GO:0001568; GO:0048854; GO:0005262; GO:0006816; GO:0005938; GO:0001708; GO:0009986; GO:0016337; GO:0005813; GO:0021795; GO:0015871; GO:0035253; GO:0031410; GO:0043198; GO:0021904; GO:0030326; GO:0004175; GO:0005783; GO:0005789; GO:0050673; GO:0070765; GO:0030426; GO:0001947; GO:0002244; GO:0005887; GO:0035556; GO:0000776; GO:0005765; GO:0006509; GO:0045121; GO:0007613; GO:0005743; GO:0006839; GO:0002573; GO:0043066; GO:2001234; GO:0050771; GO:0007175; GO:0043524; GO:2000059; GO:0000122; GO:0051444; GO:0031594; GO:0051402; GO:0048666; GO:0001764; GO:0043025; GO:0005640; GO:0005634; GO:0048471; GO:0043406; GO:0043065; GO:0050820; GO:0032436; GO:0001921; GO:0009791; GO:0006486; GO:0016485; GO:0015031; GO:0043393; GO:0060075; GO:0048167; GO:0051966; GO:0006974; GO:0006979; GO:0005791; GO:0048705; GO:0043589; GO:0005790; GO:0051563; GO:0001756; GO:0016080; GO:0048538 Q9WV31; Q9Z1G4; P52795; Q8BFZ9 "Cajal-Retzius cell differentiation; Golgi apparatus; Golgi membrane; L-glutamate transport; Notch receptor processing; Notch signaling pathway; T cell activation involved in immune response; T cell receptor signaling pathway; Z disc; activation of MAPKK activity; anagen; apical plasma membrane; aspartic-type endopeptidase activity; autophagic vacuole assembly; axon; beta-amyloid formation; blood vessel development; brain morphogenesis; calcium channel activity; calcium ion transport; cell cortex; cell fate specification; cell surface; cell-cell adhesion; centrosome; cerebral cortex cell migration; choline transport; ciliary rootlet; cytoplasmic vesicle; dendritic shaft; dorsal/ventral neural tube patterning; embryonic limb morphogenesis; endopeptidase activity; endoplasmic reticulum; endoplasmic reticulum membrane; epithelial cell proliferation; gamma-secretase complex; growth cone; heart looping; hematopoietic progenitor cell differentiation; integral to plasma membrane; intracellular signal transduction; kinetochore; lysosomal membrane; membrane protein ectodomain proteolysis; membrane raft; memory; mitochondrial inner membrane; mitochondrial transport; myeloid leukocyte differentiation; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of axonogenesis; negative regulation of epidermal growth factor-activated receptor activity; negative regulation of neuron apoptotic process; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of ubiquitin-protein ligase activity; neuromuscular junction; neuron apoptotic process; neuron development; neuron migration; neuronal cell body; nuclear outer membrane; nucleus; perinuclear region of cytoplasm; positive regulation of MAP kinase activity; positive regulation of apoptotic process; positive regulation of coagulation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of receptor recycling; post-embryonic development; protein glycosylation; protein processing; protein transport; regulation of protein binding; regulation of resting membrane potential; regulation of synaptic plasticity; regulation of synaptic transmission, glutamatergic; response to DNA damage stimulus; response to oxidative stress; rough endoplasmic reticulum; skeletal system morphogenesis; skin morphogenesis; smooth endoplasmic reticulum; smooth endoplasmic reticulum calcium ion homeostasis; somitogenesis; synaptic vesicle targeting; thymus development" IPR002031; IPR001108; IPR006639; Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)] Psen1 Ad3h Psnl1 Mus musculus (Mouse) TR39507_c0_g2_i5 Q4JIM4 PSN1_CHICK 4.00E-140 GO:0021870; GO:0005794; GO:0000139; GO:0015813; GO:0007220; GO:0007219; GO:0002286; GO:0050852; GO:0030018; GO:0000186; GO:0042987; GO:0042640; GO:0016324; GO:0004190; GO:0000045; GO:0030424; GO:0034205; GO:0050435; GO:0001568; GO:0048854; GO:0045296; GO:0005262; GO:0006816; GO:0005938; GO:0001708; GO:0009986; GO:0016337; GO:0005813; GO:0021795; GO:0015871; GO:0035253; GO:0031410; GO:0043198; GO:0021904; GO:0030326; GO:0004175; GO:0005783; GO:0005789; GO:0050673; GO:0070765; GO:0030426; GO:0001947; GO:0002244; GO:0005887; GO:0035556; GO:0000776; GO:0005765; GO:0006509; GO:0045121; GO:0007613; GO:0005743; GO:0006839; GO:0002573; GO:0043066; GO:0050771; GO:0007175; GO:2000059; GO:0000122; GO:0051444; GO:0031594; GO:0051402; GO:0048666; GO:0001764; GO:0043025; GO:0005640; GO:0005634; GO:0048471; GO:0043406; GO:0043065; GO:0043085; GO:0050820; GO:0032436; GO:0001921; GO:0009791; GO:0006486; GO:0016485; GO:0015031; GO:0042325; GO:0043393; GO:0060075; GO:0048167; GO:0051966; GO:0006974; GO:0006979; GO:0005791; GO:0048705; GO:0043589; GO:0005790; GO:0051563; GO:0001756; GO:0016080; GO:0048538 "Cajal-Retzius cell differentiation; Golgi apparatus; Golgi membrane; L-glutamate transport; Notch receptor processing; Notch signaling pathway; T cell activation involved in immune response; T cell receptor signaling pathway; Z disc; activation of MAPKK activity; amyloid precursor protein catabolic process; anagen; apical plasma membrane; aspartic-type endopeptidase activity; autophagic vacuole assembly; axon; beta-amyloid formation; beta-amyloid metabolic process; blood vessel development; brain morphogenesis; cadherin binding; calcium channel activity; calcium ion transport; cell cortex; cell fate specification; cell surface; cell-cell adhesion; centrosome; cerebral cortex cell migration; choline transport; ciliary rootlet; cytoplasmic vesicle; dendritic shaft; dorsal/ventral neural tube patterning; embryonic limb morphogenesis; endopeptidase activity; endoplasmic reticulum; endoplasmic reticulum membrane; epithelial cell proliferation; gamma-secretase complex; growth cone; heart looping; hematopoietic progenitor cell differentiation; integral to plasma membrane; intracellular signal transduction; kinetochore; lysosomal membrane; membrane protein ectodomain proteolysis; membrane raft; memory; mitochondrial inner membrane; mitochondrial transport; myeloid leukocyte differentiation; negative regulation of apoptotic process; negative regulation of axonogenesis; negative regulation of epidermal growth factor-activated receptor activity; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of ubiquitin-protein ligase activity; neuromuscular junction; neuron apoptotic process; neuron development; neuron migration; neuronal cell body; nuclear outer membrane; nucleus; perinuclear region of cytoplasm; positive regulation of MAP kinase activity; positive regulation of apoptotic process; positive regulation of catalytic activity; positive regulation of coagulation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of receptor recycling; post-embryonic development; protein glycosylation; protein processing; protein transport; regulation of phosphorylation; regulation of protein binding; regulation of resting membrane potential; regulation of synaptic plasticity; regulation of synaptic transmission, glutamatergic; response to DNA damage stimulus; response to oxidative stress; rough endoplasmic reticulum; skeletal system morphogenesis; skin morphogenesis; smooth endoplasmic reticulum; smooth endoplasmic reticulum calcium ion homeostasis; somitogenesis; synaptic vesicle targeting; thymus development" IPR002031; IPR001108; IPR006639; Presenilin-1 (PS-1) (EC 3.4.23.-) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit] PSEN1 Gallus gallus (Chicken) TR39507_c0_g2_i6 Q4JIM4 PSN1_CHICK 2.00E-103 GO:0021870; GO:0005794; GO:0000139; GO:0015813; GO:0007220; GO:0007219; GO:0002286; GO:0050852; GO:0030018; GO:0000186; GO:0042987; GO:0042640; GO:0016324; GO:0004190; GO:0000045; GO:0030424; GO:0034205; GO:0050435; GO:0001568; GO:0048854; GO:0045296; GO:0005262; GO:0006816; GO:0005938; GO:0001708; GO:0009986; GO:0016337; GO:0005813; GO:0021795; GO:0015871; GO:0035253; GO:0031410; GO:0043198; GO:0021904; GO:0030326; GO:0004175; GO:0005783; GO:0005789; GO:0050673; GO:0070765; GO:0030426; GO:0001947; GO:0002244; GO:0005887; GO:0035556; GO:0000776; GO:0005765; GO:0006509; GO:0045121; GO:0007613; GO:0005743; GO:0006839; GO:0002573; GO:0043066; GO:0050771; GO:0007175; GO:2000059; GO:0000122; GO:0051444; GO:0031594; GO:0051402; GO:0048666; GO:0001764; GO:0043025; GO:0005640; GO:0005634; GO:0048471; GO:0043406; GO:0043065; GO:0043085; GO:0050820; GO:0032436; GO:0001921; GO:0009791; GO:0006486; GO:0016485; GO:0015031; GO:0042325; GO:0043393; GO:0060075; GO:0048167; GO:0051966; GO:0006974; GO:0006979; GO:0005791; GO:0048705; GO:0043589; GO:0005790; GO:0051563; GO:0001756; GO:0016080; GO:0048538 "Cajal-Retzius cell differentiation; Golgi apparatus; Golgi membrane; L-glutamate transport; Notch receptor processing; Notch signaling pathway; T cell activation involved in immune response; T cell receptor signaling pathway; Z disc; activation of MAPKK activity; amyloid precursor protein catabolic process; anagen; apical plasma membrane; aspartic-type endopeptidase activity; autophagic vacuole assembly; axon; beta-amyloid formation; beta-amyloid metabolic process; blood vessel development; brain morphogenesis; cadherin binding; calcium channel activity; calcium ion transport; cell cortex; cell fate specification; cell surface; cell-cell adhesion; centrosome; cerebral cortex cell migration; choline transport; ciliary rootlet; cytoplasmic vesicle; dendritic shaft; dorsal/ventral neural tube patterning; embryonic limb morphogenesis; endopeptidase activity; endoplasmic reticulum; endoplasmic reticulum membrane; epithelial cell proliferation; gamma-secretase complex; growth cone; heart looping; hematopoietic progenitor cell differentiation; integral to plasma membrane; intracellular signal transduction; kinetochore; lysosomal membrane; membrane protein ectodomain proteolysis; membrane raft; memory; mitochondrial inner membrane; mitochondrial transport; myeloid leukocyte differentiation; negative regulation of apoptotic process; negative regulation of axonogenesis; negative regulation of epidermal growth factor-activated receptor activity; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of ubiquitin-protein ligase activity; neuromuscular junction; neuron apoptotic process; neuron development; neuron migration; neuronal cell body; nuclear outer membrane; nucleus; perinuclear region of cytoplasm; positive regulation of MAP kinase activity; positive regulation of apoptotic process; positive regulation of catalytic activity; positive regulation of coagulation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of receptor recycling; post-embryonic development; protein glycosylation; protein processing; protein transport; regulation of phosphorylation; regulation of protein binding; regulation of resting membrane potential; regulation of synaptic plasticity; regulation of synaptic transmission, glutamatergic; response to DNA damage stimulus; response to oxidative stress; rough endoplasmic reticulum; skeletal system morphogenesis; skin morphogenesis; smooth endoplasmic reticulum; smooth endoplasmic reticulum calcium ion homeostasis; somitogenesis; synaptic vesicle targeting; thymus development" IPR002031; IPR001108; IPR006639; Presenilin-1 (PS-1) (EC 3.4.23.-) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit] PSEN1 Gallus gallus (Chicken) TR39507_c0_g2_i7 Q90X07 PSN2_CHICK 4.00E-98 GO:0000139; GO:0007220; GO:0007219; GO:0030018; GO:0042987; GO:0016324; GO:0004190; GO:0030424; GO:0050435; GO:0006816; GO:0005938; GO:0009986; GO:0035253; GO:0043198; GO:0004175; GO:0005789; GO:0030426; GO:0005887; GO:0035556; GO:0005765; GO:0006509; GO:0045121; GO:0005743; GO:0031594; GO:0043025; GO:0005634; GO:0048471 Golgi membrane; Notch receptor processing; Notch signaling pathway; Z disc; amyloid precursor protein catabolic process; apical plasma membrane; aspartic-type endopeptidase activity; axon; beta-amyloid metabolic process; calcium ion transport; cell cortex; cell surface; ciliary rootlet; dendritic shaft; endopeptidase activity; endoplasmic reticulum membrane; growth cone; integral to plasma membrane; intracellular signal transduction; lysosomal membrane; membrane protein ectodomain proteolysis; membrane raft; mitochondrial inner membrane; neuromuscular junction; neuronal cell body; nucleus; perinuclear region of cytoplasm IPR001493; IPR001108; IPR006639; Presenilin-2 (PS-2) (EC 3.4.23.-) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] PSEN2 Gallus gallus (Chicken) TR39507_c0_g2_i8 P49810 PSN2_HUMAN 2.00E-96 GO:0005794; GO:0000139; GO:0007220; GO:0007219; GO:0002286; GO:0050852; GO:0030018; GO:0042987; GO:0042640; GO:0016324; GO:0097190; GO:0004190; GO:0030424; GO:0050435; GO:0048854; GO:0006816; GO:0060048; GO:0005938; GO:0001708; GO:0009986; GO:0005813; GO:0035253; GO:0005829; GO:0043198; GO:0021904; GO:0030326; GO:0004175; GO:0005783; GO:0032469; GO:0005789; GO:0030900; GO:0030426; GO:0002244; GO:0005887; GO:0035556; GO:0000776; GO:0040011; GO:0048286; GO:0005765; GO:0006509; GO:0031293; GO:0045121; GO:0007613; GO:0005743; GO:0002573; GO:0043066; GO:0001933; GO:0031594; GO:0043025; GO:0048011; GO:0005637; GO:0048471; GO:0043065; GO:0043085; GO:0050820; GO:0016485; GO:0015031; GO:0007176; GO:0043393; GO:0048167; GO:0001666; GO:0001756; GO:0048538 Q14204; Q9BQ95; Q53EL6 Golgi apparatus; Golgi membrane; Notch receptor processing; Notch signaling pathway; T cell activation involved in immune response; T cell receptor signaling pathway; Z disc; amyloid precursor protein catabolic process; anagen; apical plasma membrane; apoptotic signaling pathway; aspartic-type endopeptidase activity; axon; beta-amyloid metabolic process; brain morphogenesis; calcium ion transport; cardiac muscle contraction; cell cortex; cell fate specification; cell surface; centrosome; ciliary rootlet; cytosol; dendritic shaft; dorsal/ventral neural tube patterning; embryonic limb morphogenesis; endopeptidase activity; endoplasmic reticulum; endoplasmic reticulum calcium ion homeostasis; endoplasmic reticulum membrane; forebrain development; growth cone; hematopoietic progenitor cell differentiation; integral to plasma membrane; intracellular signal transduction; kinetochore; locomotion; lung alveolus development; lysosomal membrane; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; membrane raft; memory; mitochondrial inner membrane; myeloid leukocyte differentiation; negative regulation of apoptotic process; negative regulation of protein phosphorylation; neuromuscular junction; neuronal cell body; neurotrophin TRK receptor signaling pathway; nuclear inner membrane; perinuclear region of cytoplasm; positive regulation of apoptotic process; positive regulation of catalytic activity; positive regulation of coagulation; protein processing; protein transport; regulation of epidermal growth factor-activated receptor activity; regulation of protein binding; regulation of synaptic plasticity; response to hypoxia; somitogenesis; thymus development IPR001493; IPR001108; IPR006639; Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] PSEN2 AD4 PS2 PSNL2 STM2 Homo sapiens (Human) TR39509_c1_g2_i1 Q91X46 ARHG3_MOUSE 3.00E-106 GO:0005089; GO:0005737; GO:0035556; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; cytoplasm; intracellular signal transduction; phospholipid binding; regulation of Rho protein signal transduction IPR000219; IPR001331; IPR011993; IPR001849; IPR015721; Rho guanine nucleotide exchange factor 3 Arhgef3 Mus musculus (Mouse) TR3951_c0_g1_i1 Q9VUX2 MIB_DROME 9.00E-28 GO:0007219; GO:0045179; GO:0005829; GO:0006897; GO:0046331; GO:0045747; GO:0008104; GO:0007423; GO:0004842; GO:0008270 Notch signaling pathway; apical cortex; cytosol; endocytosis; lateral inhibition; positive regulation of Notch signaling pathway; protein localization; sensory organ development; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase mind-bomb (EC 6.3.2.-) (Mind bomb homolog) (D-mib) mib1 mind-bomb CG5841 Drosophila melanogaster (Fruit fly) TR39510_c0_g1_i4 Q8CAS9 PARP9_MOUSE 5.00E-18 GO:0003950; GO:0005737; GO:0005829; GO:0006302; GO:0005634; GO:0060330 NAD+ ADP-ribosyltransferase activity; cytoplasm; cytosol; double-strand break repair; nucleus; regulation of response to interferon-gamma IPR002589; IPR012317; Poly [ADP-ribose] polymerase 9 (PARP-9) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 9) (ARTD9) (B aggressive lymphoma protein homolog) Parp9 Bal Mus musculus (Mouse) TR39510_c0_g1_i5 Q8CAS9 PARP9_MOUSE 5.00E-18 GO:0003950; GO:0005737; GO:0005829; GO:0006302; GO:0005634; GO:0060330 NAD+ ADP-ribosyltransferase activity; cytoplasm; cytosol; double-strand break repair; nucleus; regulation of response to interferon-gamma IPR002589; IPR012317; Poly [ADP-ribose] polymerase 9 (PARP-9) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 9) (ARTD9) (B aggressive lymphoma protein homolog) Parp9 Bal Mus musculus (Mouse) TR39511_c8_g3_i1 Q01968 OCRL_HUMAN 0 GO:0005795; GO:0005798; GO:0030675; GO:0042384; GO:0030136; GO:0005905; GO:0005829; GO:0005769; GO:0031901; GO:0001701; GO:0043647; GO:0052745; GO:0005634; GO:0030670; GO:0006661; GO:0046856; GO:0004439; GO:0001750; GO:0005886; GO:0032314; GO:0007264; GO:0005802 Q00610; P11442; P61106; P62820; Q9H0U4; P20339; P20340; P61006; P63000 "Golgi stack; Golgi-associated vesicle; Rac GTPase activator activity; cilium assembly; clathrin-coated vesicle; coated pit; cytosol; early endosome; early endosome membrane; in utero embryonic development; inositol phosphate metabolic process; inositol phosphate phosphatase activity; nucleus; phagocytic vesicle membrane; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; photoreceptor outer segment; plasma membrane; regulation of Rac GTPase activity; small GTPase mediated signal transduction; trans-Golgi network" IPR005135; IPR000300; IPR008936; IPR000198; Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein) OCRL INPP5F OCRL1 Homo sapiens (Human) TR39512_c2_g1_i1 Q9HBG6 IF122_HUMAN 1.00E-07 GO:0048593; GO:0060830; GO:0060271; GO:0005737; GO:0010172; GO:0042733; GO:0035050; GO:0035721; GO:0030991; GO:0060173; GO:0005932; GO:0045879; GO:0001843; GO:0032391; GO:0060831 Q9Q2G4 camera-type eye morphogenesis; ciliary receptor clustering involved in smoothened signaling pathway; cilium morphogenesis; cytoplasm; embryonic body morphogenesis; embryonic digit morphogenesis; embryonic heart tube development; intraflagellar retrograde transport; intraflagellar transport particle A; limb development; microtubule basal body; negative regulation of smoothened signaling pathway; neural tube closure; photoreceptor connecting cilium; smoothened signaling pathway involved in dorsal/ventral neural tube patterning IPR011990; IPR015943; IPR001680; IPR017986; Intraflagellar transport protein 122 homolog (WD repeat-containing protein 10) (WD repeat-containing protein 140) IFT122 SPG WDR10 WDR140 Homo sapiens (Human) TR39512_c2_g2_i1 P49695 PKWA_THECU 2.00E-50 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR020472; IPR011009; IPR000719; IPR017441; IPR008271; IPR015943; IPR001680; IPR019775; IPR017986; Probable serine/threonine-protein kinase PkwA (EC 2.7.11.1) pkwA pkw1 Thermomonospora curvata TR39512_c2_g2_i2 Q6P2Y2 WDR69_XENTR 6.00E-176 GO:0005929 cilium IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Dynein assembly factor with WDR repeat domains 1 (Outer row dynein assembly protein 16 homolog) (WD repeat-containing protein 69) daw1 wdr69 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39513_c0_g2_i12 Q9LUU7 P2C43_ARATH 3.00E-31 GO:0046872; GO:0006470; GO:0004722 metal ion binding; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; Probable protein phosphatase 2C 43 (AtPP2C43) (EC 3.1.3.16) At3g17250 MGD8.13 MGD8.8 Arabidopsis thaliana (Mouse-ear cress) TR39513_c0_g2_i2 P49596 PP2C2_CAEEL 2.00E-138 GO:0046872; GO:0006470; GO:0004722 metal ion binding; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; Probable protein phosphatase 2C T23F11.1 (PP2C) (EC 3.1.3.16) T23F11.1 Caenorhabditis elegans TR39513_c0_g2_i3 Q9LUU7 P2C43_ARATH 3.00E-31 GO:0046872; GO:0006470; GO:0004722 metal ion binding; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; Probable protein phosphatase 2C 43 (AtPP2C43) (EC 3.1.3.16) At3g17250 MGD8.13 MGD8.8 Arabidopsis thaliana (Mouse-ear cress) TR39513_c0_g2_i4 Q7XU84 P2C42_ORYSJ 8.00E-57 GO:0046872; GO:0006470; GO:0004722 metal ion binding; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; Probable protein phosphatase 2C 42 (OsPP2C42) (EC 3.1.3.16) Os04g0500900 LOC_Os04g42260 OSJNBa0029H02.20 Oryza sativa subsp. japonica (Rice) TR39513_c0_g2_i5 P49596 PP2C2_CAEEL 6.00E-128 GO:0046872; GO:0006470; GO:0004722 metal ion binding; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; Probable protein phosphatase 2C T23F11.1 (PP2C) (EC 3.1.3.16) T23F11.1 Caenorhabditis elegans TR39513_c0_g2_i8 P49596 PP2C2_CAEEL 9.00E-140 GO:0046872; GO:0006470; GO:0004722 metal ion binding; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; Probable protein phosphatase 2C T23F11.1 (PP2C) (EC 3.1.3.16) T23F11.1 Caenorhabditis elegans TR39513_c0_g2_i9 Q09173 PP2C3_SCHPO 1.00E-90 GO:0005829; GO:0000173; GO:0046872; GO:0005634; GO:0006470; GO:0004722 cytosol; inactivation of MAPK activity involved in osmosensory signaling pathway; metal ion binding; nucleus; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; Protein phosphatase 2C homolog 3 (PP2C-3) (EC 3.1.3.16) ptc3 SPAC2G11.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR39515_c3_g1_i1 P20594 ANPRB_HUMAN 5.00E-146 GO:0005524; GO:0005525; GO:0060348; GO:0097011; GO:0004383; GO:0042562; GO:0016021; GO:0035556; GO:0016941; GO:0001503; GO:0017046; GO:0005886; GO:0004672; GO:0007168; GO:0008217; GO:0004888 ATP binding; GTP binding; bone development; cellular response to granulocyte macrophage colony-stimulating factor stimulus; guanylate cyclase activity; hormone binding; integral to membrane; intracellular signal transduction; natriuretic peptide receptor activity; ossification; peptide hormone binding; plasma membrane; protein kinase activity; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; transmembrane signaling receptor activity IPR001054; IPR018297; IPR001828; IPR011009; IPR001170; IPR028082; IPR000719; IPR001245; Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B) NPR2 ANPRB Homo sapiens (Human) TR39517_c1_g1_i1 Q99MS3 MP17L_MOUSE 2.00E-28 GO:0016021; GO:0005739; GO:0005778; GO:0005777; GO:0072593 integral to membrane; mitochondrion; peroxisomal membrane; peroxisome; reactive oxygen species metabolic process IPR007248; Mpv17-like protein (M-LP) Mpv17l Mus musculus (Mouse) TR39517_c2_g1_i1 Q8R3N6 THOC1_MOUSE 0 GO:0003677; GO:0003723; GO:0008380; GO:0000445; GO:0006915; GO:0005737; GO:0046784; GO:0006397; GO:0016363; GO:0016607; GO:0032784; GO:0007165; GO:0006351 "DNA binding; RNA binding; RNA splicing; THO complex part of transcription export complex; apoptotic process; cytoplasm; intronless viral mRNA export from host nucleus; mRNA processing; nuclear matrix; nuclear speck; regulation of DNA-dependent transcription, elongation; signal transduction; transcription, DNA-dependent" IPR011029; IPR000488; IPR021861; THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) Thoc1 Hpr1 Mus musculus (Mouse) TR39518_c2_g1_i2 Q8VDL4 ADPGK_MOUSE 1.00E-48 GO:0043843; GO:0005576; GO:0006096; GO:0046872 ADP-specific glucokinase activity; extracellular region; glycolysis; metal ion binding IPR007666; Carbohydrate degradation; glycolysis. ADP-dependent glucokinase (ADP-GK) (ADPGK) (EC 2.7.1.147) Adpgk Mus musculus (Mouse) TR39522_c1_g2_i1 Q5RCK6 SYT10_PONAB 6.00E-45 GO:0030054; GO:0016021; GO:0046872; GO:0030672; GO:0005215 cell junction; integral to membrane; metal ion binding; synaptic vesicle membrane; transporter activity IPR000008; IPR001565; Synaptotagmin-10 (Synaptotagmin X) (SytX) SYT10 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39522_c1_g2_i2 Q9BQS2 SYT15_HUMAN 1.00E-81 GO:0019898; GO:0016021; GO:0005886 extrinsic to membrane; integral to membrane; plasma membrane IPR000008; Synaptotagmin-15 (Chr10Syt) (Synaptotagmin XV) (SytXV) SYT15 Homo sapiens (Human) TR39522_c1_g2_i5 Q86SS6 SYT9_HUMAN 4.00E-48 GO:0030054; GO:0031045; GO:0016021; GO:0046872; GO:0017158; GO:0050796; GO:0030667; GO:0030672; GO:0005215 cell junction; dense core granule; integral to membrane; metal ion binding; regulation of calcium ion-dependent exocytosis; regulation of insulin secretion; secretory granule membrane; synaptic vesicle membrane; transporter activity IPR000008; IPR001565; Synaptotagmin-9 (Synaptotagmin IX) (SytIX) SYT9 Homo sapiens (Human) TR39522_c1_g2_i7 Q9BQS2 SYT15_HUMAN 9.00E-33 GO:0019898; GO:0016021; GO:0005886 extrinsic to membrane; integral to membrane; plasma membrane IPR000008; Synaptotagmin-15 (Chr10Syt) (Synaptotagmin XV) (SytXV) SYT15 Homo sapiens (Human) TR39523_c3_g1_i1 Q5E9E1 PDLI1_BOVIN 5.00E-13 GO:0005737; GO:0005856; GO:0006355; GO:0003713; GO:0005667; GO:0008270 "cytoplasm; cytoskeleton; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription factor complex; zinc ion binding" IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein 1 (Elfin) PDLIM1 Bos taurus (Bovine) TR39525_c3_g2_i1 Q8BL65 ABLM2_MOUSE 1.00E-11 GO:0015629; GO:0007010; GO:0030016; GO:0045944; GO:0008270 actin cytoskeleton; cytoskeleton organization; myofibril; positive regulation of transcription from RNA polymerase II promoter; zinc ion binding IPR003128; IPR001781; Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2) Ablim2 Mus musculus (Mouse) TR39526_c0_g1_i4 Q3SZZ7 FGL1_BOVIN 5.00E-50 GO:0005576 extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein 1 FGL1 Bos taurus (Bovine) TR39529_c0_g2_i3 P32234 128UP_DROME 0 GO:0005525 GTP binding IPR006074; IPR006073; IPR027417; IPR005225; IPR004095; IPR012676; GTP-binding protein 128up 128up GTP-bp CG8340 Drosophila melanogaster (Fruit fly) TR39531_c5_g6_i1 Q3T178 VPS28_BOVIN 5.00E-103 GO:0000813; GO:0031902; GO:0031397; GO:0005886; GO:0015031; GO:0043162 ESCRT I complex; late endosome membrane; negative regulation of protein ubiquitination; plasma membrane; protein transport; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IPR007143; IPR017899; IPR017898; Vacuolar protein sorting-associated protein 28 homolog (ESCRT-I complex subunit VPS28) VPS28 Bos taurus (Bovine) TR39532_c0_g1_i1 Q9WUQ2 PREB_MOUSE 1.00E-70 GO:0003677; GO:0005783; GO:0016021; GO:0005634; GO:0015031; GO:0003700; GO:0006351; GO:0016192 "DNA binding; endoplasmic reticulum; integral to membrane; nucleus; protein transport; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; vesicle-mediated transport" IPR011047; IPR015943; IPR001680; IPR017986; Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12) Preb Sec12 Mus musculus (Mouse) TR39532_c0_g1_i3 Q9WUQ2 PREB_MOUSE 1.00E-70 GO:0003677; GO:0005783; GO:0016021; GO:0005634; GO:0015031; GO:0003700; GO:0006351; GO:0016192 "DNA binding; endoplasmic reticulum; integral to membrane; nucleus; protein transport; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; vesicle-mediated transport" IPR011047; IPR015943; IPR001680; IPR017986; Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12) Preb Sec12 Mus musculus (Mouse) TR39533_c0_g2_i3 B1H2T2 DIA1_XENTR 2.00E-95 GO:0060038; GO:0005615; GO:0014066 cardiac muscle cell proliferation; extracellular space; regulation of phosphatidylinositol 3-kinase cascade IPR022049; IPR020519; Deleted in autism protein 1 homolog Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39533_c1_g1_i2 Q8SRI3 MRK1_ENCCU 3.00E-12 GO:0005524; GO:0051301; GO:0005737; GO:0007067; GO:0005634; GO:0004674 ATP binding; cell division; cytoplasm; mitosis; nucleus; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Probable serine/threonine-protein kinase MRK1 homolog (EC 2.7.11.1) MRK1 ECU07_1270 Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) TR39533_c1_g1_i4 O54784 DAPK3_MOUSE 3.00E-12 GO:0005524; GO:0016605; GO:0097190; GO:0071346; GO:0016568; GO:0000775; GO:0005737; GO:0007243; GO:0005815; GO:0017148; GO:0030182; GO:0090263; GO:2001241; GO:0046777; GO:0042803; GO:0004674; GO:0006355; GO:0006351 O35613; Q925B0 "ATP binding; PML body; apoptotic signaling pathway; cellular response to interferon-gamma; chromatin modification; chromosome, centromeric region; cytoplasm; intracellular protein kinase cascade; microtubule organizing center; negative regulation of translation; neuron differentiation; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; protein autophosphorylation; protein homodimerization activity; protein serine/threonine kinase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011009; IPR020675; IPR000719; IPR017441; IPR002290; IPR008271; Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (ZIP-kinase) Dapk3 Zipk Mus musculus (Mouse) TR39534_c1_g1_i5 E9Q555 RN213_MOUSE 9.00E-63 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) Rnf213 Mus musculus (Mouse) TR39534_c1_g1_i8 E9Q555 RN213_MOUSE 3.00E-38 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) Rnf213 Mus musculus (Mouse) TR39536_c0_g1_i1 Q6NU46 THILA_XENLA 5.00E-179 GO:0003985; GO:0046872; GO:0005739 acetyl-CoA C-acetyltransferase activity; metal ion binding; mitochondrion IPR002155; IPR016039; IPR016038; IPR020615; IPR020610; IPR020617; IPR020613; IPR020616; "Acetyl-CoA acetyltransferase A, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase A)" acat1-a Xenopus laevis (African clawed frog) TR39536_c0_g1_i2 Q86AD9 THIL1_DICDI 4.00E-118 GO:0003985; GO:0005829; GO:0006696; GO:0046872 acetyl-CoA C-acetyltransferase activity; cytosol; ergosterol biosynthetic process; metal ion binding IPR002155; IPR016039; IPR016038; IPR020615; IPR020617; IPR020613; IPR020616; Probable acetyl-CoA acetyltransferase (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) DDB_G0271544 Dictyostelium discoideum (Slime mold) TR39536_c0_g1_i3 P45362 THL_CLODI 1.00E-21 GO:0003985; GO:0005737 acetyl-CoA C-acetyltransferase activity; cytoplasm IPR002155; IPR016039; IPR016038; IPR020616; Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3. Acetyl-CoA acetyltransferase (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (Fragment) thi Clostridium difficile TR39538_c0_g1_i4 Q8NHP7 EXD1_HUMAN 2.00E-13 GO:0008408; GO:0003676; GO:0090305 3'-5' exonuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis IPR002562; IPR012337; Exonuclease 3'-5' domain-containing protein 1 (Exonuclease 3'-5' domain-like-containing protein 1) EXD1 EXDL1 Homo sapiens (Human) TR39538_c0_g1_i6 Q6NRD5 EXD1_XENLA 5.00E-14 GO:0008408; GO:0003676; GO:0090305 3'-5' exonuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis IPR002562; IPR012337; Exonuclease 3'-5' domain-containing protein 1 (Exonuclease 3'-5' domain-like-containing protein 1) exd1 exdl1 Xenopus laevis (African clawed frog) TR39538_c0_g1_i8 Q6NRD5 EXD1_XENLA 5.00E-14 GO:0008408; GO:0003676; GO:0090305 3'-5' exonuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis IPR002562; IPR012337; Exonuclease 3'-5' domain-containing protein 1 (Exonuclease 3'-5' domain-like-containing protein 1) exd1 exdl1 Xenopus laevis (African clawed frog) TR39538_c0_g1_i9 Q8NHP7 EXD1_HUMAN 3.00E-13 GO:0008408; GO:0003676; GO:0090305 3'-5' exonuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis IPR002562; IPR012337; Exonuclease 3'-5' domain-containing protein 1 (Exonuclease 3'-5' domain-like-containing protein 1) EXD1 EXDL1 Homo sapiens (Human) TR39539_c3_g1_i1 Q68E01 INT3_HUMAN 4.00E-167 GO:0006281; GO:0070876; GO:0032039; GO:0007093; GO:0010212; GO:0016180 DNA repair; SOSS complex; integrator complex; mitotic cell cycle checkpoint; response to ionizing radiation; snRNA processing IPR019333; Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A) INTS3 C1orf193 C1orf60 Homo sapiens (Human) TR39540_c1_g3_i1 Q6T3U3 NPCL1_RAT 4.00E-24 GO:0016324; GO:0031526; GO:0006695; GO:0008144; GO:0008158; GO:0016021; GO:0030299; GO:0042157; GO:0042493 apical plasma membrane; brush border membrane; cholesterol biosynthetic process; drug binding; hedgehog receptor activity; integral to membrane; intestinal cholesterol absorption; lipoprotein metabolic process; response to drug IPR004765; IPR003392; IPR000731; Niemann-Pick C1-like protein 1 Npc1l1 Rattus norvegicus (Rat) TR39540_c1_g4_i1 Q09614 PTC1_CAEEL 7.00E-15 GO:0051301; GO:0008158; GO:0005887; GO:0007067; GO:0018996 "cell division; hedgehog receptor activity; integral to plasma membrane; mitosis; molting cycle, collagen and cuticulin-based cuticle" IPR003392; IPR000731; Protein patched homolog 1 ptc-1 ZK675.1 Caenorhabditis elegans TR39541_c0_g1_i1 Q8IWJ2 GCC2_HUMAN 2.00E-43 GO:0005794; GO:0090161; GO:0034499; GO:0016020; GO:0034453; GO:0031023; GO:0005634; GO:0034067; GO:0000042; GO:0006622; GO:0071955; GO:0070861; GO:0005802 Itself; P20340 Golgi apparatus; Golgi ribbon formation; late endosome to Golgi transport; membrane; microtubule anchoring; microtubule organizing center organization; nucleus; protein localization to Golgi apparatus; protein targeting to Golgi; protein targeting to lysosome; recycling endosome to Golgi transport; regulation of protein exit from endoplasmic reticulum; trans-Golgi network IPR000237; GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) (CLL-associated antigen KW-11) (CTCL tumor antigen se1-1) (Ran-binding protein 2-like 4) (RanBP2L4) (Renal carcinoma antigen NY-REN-53) GCC2 KIAA0336 RANBP2L4 Homo sapiens (Human) TR39541_c3_g2_i1 Q8CHG3 GCC2_MOUSE 3.00E-21 GO:0005794; GO:0090161; GO:0034499; GO:0016020; GO:0034453; GO:0031023; GO:0034067; GO:0000042; GO:0006622; GO:0071955; GO:0070861; GO:0005802 Q8BH43 Golgi apparatus; Golgi ribbon formation; late endosome to Golgi transport; membrane; microtubule anchoring; microtubule organizing center organization; protein localization to Golgi apparatus; protein targeting to Golgi; protein targeting to lysosome; recycling endosome to Golgi transport; regulation of protein exit from endoplasmic reticulum; trans-Golgi network IPR000237; GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) Gcc2 Kiaa0336 Mus musculus (Mouse) TR39541_c3_g2_i4 Q7Z3J3 RGPD4_HUMAN 4.00E-14 GO:0000042 protein targeting to Golgi IPR000237; IPR011993; IPR000156; IPR013026; IPR011990; IPR001440; IPR019734; RanBP2-like and GRIP domain-containing protein 4 RGPD4 RGP4 Homo sapiens (Human) TR39543_c0_g1_i5 Q9QY66 ZNHI2_MOUSE 7.00E-20 GO:0046872 metal ion binding IPR007529; Zinc finger HIT domain-containing protein 2 (Protein FON) Znhit2 ORF6 Mus musculus (Mouse) TR39544_c0_g3_i1 A5PJI7 EI2BG_BOVIN 3.00E-08 GO:0051716; GO:0005851; GO:0016779; GO:0014003; GO:0003743; GO:0006413 cellular response to stimulus; eukaryotic translation initiation factor 2B complex; nucleotidyltransferase activity; oligodendrocyte development; translation initiation factor activity; translational initiation IPR005835; Translation initiation factor eIF-2B subunit gamma (eIF-2B GDP-GTP exchange factor subunit gamma) EIF2B3 Bos taurus (Bovine) TR39544_c0_g3_i2 Q8CHW4 EI2BE_MOUSE 2.00E-158 GO:0014002; GO:0035690; GO:0005851; GO:0042552; GO:0032057; GO:0005634; GO:0014003; GO:0001541; GO:0045948; GO:0034976; GO:0009749; GO:0009408; GO:0043434; GO:0003743; GO:0006413 astrocyte development; cellular response to drug; eukaryotic translation initiation factor 2B complex; myelination; negative regulation of translational initiation in response to stress; nucleus; oligodendrocyte development; ovarian follicle development; positive regulation of translational initiation; response to endoplasmic reticulum stress; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translation initiation factor activity; translational initiation IPR016024; IPR001451; IPR016021; IPR011004; IPR003307; Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon) Eif2b5 Mus musculus (Mouse) TR39544_c0_g3_i3 Q54FQ8 EI2BG_DICDI 3.00E-09 GO:0016779; GO:0003743 nucleotidyltransferase activity; translation initiation factor activity IPR001451; IPR005835; Translation initiation factor eIF-2B subunit gamma (eIF-2B GDP-GTP exchange factor subunit gamma) eif2b3 DDB_G0290693 Dictyostelium discoideum (Slime mold) TR39544_c0_g3_i4 D4GYH1 AGLF_HALVD 4.00E-06 GO:0045232; GO:0003983; GO:0009058 S-layer organization; UTP:glucose-1-phosphate uridylyltransferase activity; biosynthetic process IPR005835; Cell surface structure biogenesis; S-layer biogenesis. UTP--glucose-1-phosphate uridylyltransferase AglF (EC 2.7.7.9) (Archaeal glycosylation protein F) aglF HVO_1527 Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) TR39545_c0_g1_i2 Q4R381 EZH2_MACFA 8.00E-99 GO:0035098; GO:0003682; GO:0034968; GO:0018024; GO:0045814; GO:0048387; GO:0000122; GO:0043406; GO:0032320; GO:0010718; GO:0006351 "ESC/E(Z) complex; chromatin binding; histone lysine methylation; histone-lysine N-methyltransferase activity; negative regulation of gene expression, epigenetic; negative regulation of retinoic acid receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of MAP kinase activity; positive regulation of Ras GTPase activity; positive regulation of epithelial to mesenchymal transition; transcription, DNA-dependent" IPR026489; IPR021654; IPR001005; IPR001214; Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.43) (Enhancer of zeste homolog 2) EZH2 QtsA-15957 QtsA-18821 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR39545_c0_g2_i1 Q8S4P4 EZ3_MAIZE 1.00E-67 GO:0031519; GO:0003682; GO:0034968; GO:0018024; GO:0006355; GO:0006351 "PcG protein complex; chromatin binding; histone lysine methylation; histone-lysine N-methyltransferase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR026489; IPR025778; IPR001005; IPR001214; Histone-lysine N-methyltransferase EZ3 (EC 2.1.1.43) (Enhancer of zeste protein 3) EZ3 MEZ3 Zea mays (Maize) TR39545_c0_g2_i2 P42124 EZ_DROME 2.00E-121 GO:0003677; GO:0035098; GO:0007411; GO:0003682; GO:0006723; GO:0048813; GO:0016458; GO:0046976; GO:0046974; GO:0007517; GO:0045892; GO:0000790; GO:0003700; GO:0035186; GO:0006351 Q9VEX9; Q24572; P41046; Q24338; Q95SW6; Q24459; Q94517 "DNA binding; ESC/E(Z) complex; axon guidance; chromatin binding; cuticle hydrocarbon biosynthetic process; dendrite morphogenesis; gene silencing; histone methyltransferase activity (H3-K27 specific); histone methyltransferase activity (H3-K9 specific); muscle organ development; negative regulation of transcription, DNA-dependent; nuclear chromatin; sequence-specific DNA binding transcription factor activity; syncytial blastoderm mitotic cell cycle; transcription, DNA-dependent" IPR026489; IPR001005; IPR001214; Histone-lysine N-methyltransferase E(z) (EC 2.1.1.43) (Lysine N-methyltransferase 6) (Protein enhancer of zeste) E(z) KMT6 CG6502 Drosophila melanogaster (Fruit fly) TR39546_c1_g1_i1 P16333 NCK1_HUMAN 6.00E-06 GO:0038096; GO:0042110; GO:0050852; GO:0007015; GO:0007411; GO:0016477; GO:0008093; GO:0005829; GO:0005783; GO:0045087; GO:0030032; GO:0060548; GO:0005634; GO:0005886; GO:0042102; GO:0030838; GO:0045944; GO:0004860; GO:0030159; GO:0006417; GO:0051707; GO:0007172; GO:0012506 Q9H222; P00519; P42684; Q15109; O43918; O15085; Q9ULH1; Q96NS5; Q9UIF9; O60885; Q9ULD4; P13671; P20810; P20963; P07766; P30260; Q9NYQ7; Q13111; Q14008; P78357; P78329; P98082; Q14118; O14490; Q9P1A6; O95886; Q9Y2H0; Q92988; Q05193; Q8IZD9; Q9H1R2; Q9H8V3; P41970; P42566; O00254; Q9BQ89; P31994; P31995; O75369; O75593; O15117; Q9UBS5; Q99259; P10912; Q9NZM4; P15586; O43708; P10412; O43390; P47928; Q9H9L3; O60674; P35968; Q9UMN6; Q13094; Q9BY71; P27816; Q92918; Q9Y4K4; Q9NQ76; Q15746; Q8WX92; P43699; O60500; Q13177; Q13087; O75167; O00750; Q9UL42; Q9BXM0; P29074; P15918; Q13905; P20936; Q9UQ26; Q8TB24; P26373; P78345; P10301; Q96GP6; O75326; Q9NZV5; Q9UPX8; Q9BYB0; Q13796; Q9UHI7; O60721; Q9UMY4; Q15036; Q9Y5X2; Q07889; Q07890; P08047; Q96T58; Q9H5I1; O15056; O43493; P42167; Q15661; Q9ULW0; Q9BWF2; Q9HCM9; O00294; Q96RL7; O43516 Fc-gamma receptor signaling pathway involved in phagocytosis; T cell activation; T cell receptor signaling pathway; actin filament organization; axon guidance; cell migration; cytoskeletal adaptor activity; cytosol; endoplasmic reticulum; innate immune response; lamellipodium assembly; negative regulation of cell death; nucleus; plasma membrane; positive regulation of T cell proliferation; positive regulation of actin filament polymerization; positive regulation of transcription from RNA polymerase II promoter; protein kinase inhibitor activity; receptor signaling complex scaffold activity; regulation of translation; response to other organism; signal complex assembly; vesicle membrane IPR017304; IPR000980; IPR001452; Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1) (SH2/SH3 adaptor protein NCK-alpha) NCK1 NCK Homo sapiens (Human) TR39546_c1_g1_i3 A8PWF6 MYO1_MALGO 1.00E-11 GO:0005524; GO:0030479; GO:0003774; GO:0016459 ATP binding; actin cortical patch; motor activity; myosin complex IPR001609; IPR010926; IPR027417; IPR001452; Myosin-1 (Class I unconventional myosin) (Type I myosin) MYO1 MGL_1086 Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated fungus) TR39546_c2_g1_i1 A2AAY5 SPD2B_MOUSE 1.00E-106 GO:0042169; GO:0060612; GO:0060348; GO:0007154; GO:0030154; GO:0030054; GO:0042995; GO:0005737; GO:0022617; GO:0001654; GO:0007507; GO:0080025; GO:0032266; GO:0070273; GO:0010314; GO:0002102; GO:0071800; GO:0045600; GO:0072657; GO:0006801 "SH2 domain binding; adipose tissue development; bone development; cell communication; cell differentiation; cell junction; cell projection; cytoplasm; extracellular matrix disassembly; eye development; heart development; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; podosome; podosome assembly; positive regulation of fat cell differentiation; protein localization to membrane; superoxide metabolic process" IPR001683; IPR011511; IPR001452; SH3 and PX domain-containing protein 2B (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) Sh3pxd2b Fad49 Tks4 Mus musculus (Mouse) TR39548_c0_g1_i1 Q9Y5X5 NPFF2_HUMAN 3.00E-07 GO:0004930; GO:0015629; GO:0009582; GO:0005887; GO:0008188; GO:0007218; GO:0043408; GO:0045761; GO:2000479 G-protein coupled receptor activity; actin cytoskeleton; detection of abiotic stimulus; integral to plasma membrane; neuropeptide receptor activity; neuropeptide signaling pathway; regulation of MAPK cascade; regulation of adenylate cyclase activity; regulation of cAMP-dependent protein kinase activity IPR000276; IPR017452; IPR005395; IPR005397; Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) NPFFR2 GPR74 NPFF2 NPGPR Homo sapiens (Human) TR39548_c0_g1_i2 P30560 V1AR_RAT 1.00E-09 GO:0031894; GO:0019722; GO:0042631; GO:0031410; GO:0030659; GO:0007204; GO:0007625; GO:0016021; GO:0002125; GO:0042711; GO:0014902; GO:0007621; GO:0051970; GO:0043084; GO:0017046; GO:0005886; GO:0030307; GO:0008284; GO:0032849; GO:0014049; GO:0045819; GO:0010460; GO:0031394; GO:0035815; GO:0003084; GO:0035810; GO:0045907; GO:0051459; GO:0001992; GO:0051412; GO:0035176; GO:0042713; GO:0021537; GO:0005000 V1A vasopressin receptor binding; calcium-mediated signaling; cellular response to water deprivation; cytoplasmic vesicle; cytoplasmic vesicle membrane; elevation of cytosolic calcium ion concentration; grooming behavior; integral to membrane; maternal aggressive behavior; maternal behavior; myotube differentiation; negative regulation of female receptivity; negative regulation of transmission of nerve impulse; penile erection; peptide hormone binding; plasma membrane; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cellular pH reduction; positive regulation of glutamate secretion; positive regulation of glycogen catabolic process; positive regulation of heart rate; positive regulation of prostaglandin biosynthetic process; positive regulation of renal sodium excretion; positive regulation of systemic arterial blood pressure; positive regulation of urine volume; positive regulation of vasoconstriction; regulation of corticotropin secretion; regulation of systemic arterial blood pressure by vasopressin; response to corticosterone stimulus; social behavior; sperm ejaculation; telencephalon development; vasopressin receptor activity IPR015076; IPR000276; IPR017452; IPR001817; IPR001224; Vasopressin V1a receptor (V1aR) (AVPR V1a) (Antidiuretic hormone receptor 1a) (Vascular/hepatic-type arginine vasopressin receptor) Avpr1a Rattus norvegicus (Rat) TR39550_c1_g2_i2 P35624 TIMP1_PIG 3.00E-07 GO:0043249; GO:0005576; GO:0046872; GO:0008191 erythrocyte maturation; extracellular region; metal ion binding; metalloendopeptidase inhibitor activity IPR001134; IPR001820; IPR008993; IPR015611; IPR027465; Metalloproteinase inhibitor 1 (Tissue inhibitor of metalloproteinases 1) (TIMP-1) TIMP1 Sus scrofa (Pig) TR39550_c1_g2_i5 P20414 TIMP1_BOVIN 4.00E-07 GO:0005604; GO:0043249; GO:0046872; GO:0008191; GO:0051045; GO:1901164 basement membrane; erythrocyte maturation; metal ion binding; metalloendopeptidase inhibitor activity; negative regulation of membrane protein ectodomain proteolysis; negative regulation of trophoblast cell migration IPR001134; IPR001820; IPR008993; IPR015611; IPR027465; Metalloproteinase inhibitor 1 (Embryogenin-1) (EG-1) (Tissue inhibitor of metalloproteinases 1) (TIMP-1) TIMP1 Bos taurus (Bovine) TR39551_c1_g3_i2 Q5FWH7 S39AC_MOUSE 7.00E-41 GO:0016021; GO:0046873 integral to membrane; metal ion transmembrane transporter activity IPR003689; Zinc transporter ZIP12 (Solute carrier family 39 member 12) (Zrt- and Irt-like protein 12) (ZIP-12) Slc39a12 Zip12 Mus musculus (Mouse) TR39552_c0_g3_i1 Q9Y620 RA54B_HUMAN 0 GO:0005524; GO:0003677; GO:0003678; GO:0015616; GO:0003724; GO:0000724; GO:0006312; GO:0005634; GO:0007131 ATP binding; DNA binding; DNA helicase activity; DNA translocase activity; RNA helicase activity; double-strand break repair via homologous recombination; mitotic recombination; nucleus; reciprocal meiotic recombination IPR014001; IPR001650; IPR027417; IPR000330; DNA repair and recombination protein RAD54B (EC 3.6.4.-) (RAD54 homolog B) RAD54B Homo sapiens (Human) TR39553_c0_g1_i1 Q2LK54 COL12_CHICK 7.00E-07 GO:0030246; GO:0005581; GO:0016021; GO:0046872 carbohydrate binding; collagen; integral to membrane; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-12 (Collectin-3) (CL-3) (cCL-3) COLEC12 CL3 Gallus gallus (Chicken) TR39553_c3_g3_i1 P86854 PLCL_MYTGA 4.00E-15 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR39555_c6_g2_i3 Q8SQB8 ITB6_BOVIN 2.00E-23 GO:0007160; GO:0008305; GO:0007229; GO:0019048; GO:0007275; GO:0009615; GO:0001618 cell-matrix adhesion; integrin complex; integrin-mediated signaling pathway; modulation by virus of host morphology or physiology; multicellular organismal development; response to virus; virus receptor activity IPR015812; IPR015436; IPR014836; IPR002369; IPR012896; IPR016201; IPR002035; Integrin beta-6 ITGB6 Bos taurus (Bovine) TR39555_c6_g2_i4 P12607 ITB1B_XENLA 6.00E-27 GO:0007160; GO:0032154; GO:0008305; GO:0007229; GO:0030027; GO:0042470; GO:0007275; GO:0004872; GO:0001726 cell-matrix adhesion; cleavage furrow; integrin complex; integrin-mediated signaling pathway; lamellipodium; melanosome; multicellular organismal development; receptor activity; ruffle IPR013111; IPR027071; IPR015812; IPR014836; IPR002369; IPR012896; IPR016201; IPR002035; Integrin beta-1-B (Integrin beta-1*) itgb1-b Xenopus laevis (African clawed frog) TR39555_c6_g2_i6 Q27874 PAT3_CAEEL 3.00E-17 GO:0031430; GO:0007155; GO:0009986; GO:0008305; GO:0007229; GO:0007275; GO:0055001; GO:0043005; GO:0043025; GO:0040017; GO:0004872; GO:0055120 M band; cell adhesion; cell surface; integrin complex; integrin-mediated signaling pathway; multicellular organismal development; muscle cell development; neuron projection; neuronal cell body; positive regulation of locomotion; receptor activity; striated muscle dense body IPR000742; IPR015812; IPR014836; IPR002369; IPR012896; IPR016201; IPR002035; Integrin beta pat-3 (Paralyzed arrest at two-fold protein 3) pat-3 ZK1058.2 Caenorhabditis elegans TR39555_c6_g2_i7 P18084 ITB5_HUMAN 2.00E-24 GO:0002479; GO:0007155; GO:0031252; GO:0030198; GO:0005925; GO:0008305; GO:0007229; GO:0007275; GO:0006936; GO:0045335; GO:0005886; GO:0004872 Q9BY76; P06756; Q9HD67 "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell adhesion; cell leading edge; extracellular matrix organization; focal adhesion; integrin complex; integrin-mediated signaling pathway; multicellular organismal development; muscle contraction; phagocytic vesicle; plasma membrane; receptor activity" IPR000742; IPR027067; IPR015812; IPR014836; IPR002369; IPR012896; IPR016201; IPR002035; Integrin beta-5 ITGB5 Homo sapiens (Human) TR39556_c0_g1_i1 Q99805 TM9S2_HUMAN 0 GO:0005768; GO:0010008; GO:0005887; GO:0006810 endosome; endosome membrane; integral to plasma membrane; transport IPR004240; Transmembrane 9 superfamily member 2 (p76) TM9SF2 Homo sapiens (Human) TR39556_c0_g1_i2 P32802 TMN1_YEAST 5.00E-114 GO:0006878; GO:0016197; GO:0005768; GO:0010008; GO:0000329; GO:0016021; GO:0001403; GO:0007124; GO:0007034 P25376; P39010; P11076; Q08280; P04817; P38310; P19145; P19807; P30605; P09620; Q12057; P40975; P87284; Q12270; P43621; P39986; Q03687 cellular copper ion homeostasis; endosomal transport; endosome; endosome membrane; fungal-type vacuole membrane; integral to membrane; invasive growth in response to glucose limitation; pseudohyphal growth; vacuolar transport IPR004240; Transmembrane 9 superfamily member 1 (70 kDa endomembrane protein) (Endomembrane protein EMP70) [Cleaved into: Protein p24a (Acidic 24 kDa late endocytic intermediate component)] EMP70 TMN1 YLR083C L2385 L9449.11 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39556_c0_g1_i4 Q99805 TM9S2_HUMAN 0 GO:0005768; GO:0010008; GO:0005887; GO:0006810 endosome; endosome membrane; integral to plasma membrane; transport IPR004240; Transmembrane 9 superfamily member 2 (p76) TM9SF2 Homo sapiens (Human) TR39557_c0_g2_i1 E1BD52 TM245_BOVIN 4.00E-133 GO:0016021 integral to membrane IPR002549; Transmembrane protein 245 TMEM245 Bos taurus (Bovine) TR39557_c0_g2_i3 D3ZXD8 TM245_RAT 4.00E-33 GO:0016021 integral to membrane IPR002549; Transmembrane protein 245 Tmem245 Rattus norvegicus (Rat) TR39558_c0_g1_i1 P93654 SYP22_ARATH 2.00E-22 GO:0009660; GO:0016021; GO:0006886; GO:0031902; GO:0009959; GO:0009705; GO:0010118; GO:0007033; GO:0016192 Q9SEL6 amyloplast organization; integral to membrane; intracellular protein transport; late endosome membrane; negative gravitropism; plant-type vacuole membrane; stomatal movement; vacuole organization; vesicle-mediated transport IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin-22 (AtSYP22) (AtVAM3) SYP22 VAM3 At5g46860 MSD23.9 Arabidopsis thaliana (Mouse-ear cress) TR39558_c0_g1_i3 O04378 SYP23_ARATH 3.00E-20 GO:0016021; GO:0006886; GO:0016192 integral to membrane; intracellular protein transport; vesicle-mediated transport IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin-23 (AtPLP) (AtSYP23) (AtPEP12-like protein) SYP23 At4g17730 dl4901w FCAALL.117 Arabidopsis thaliana (Mouse-ear cress) TR39558_c0_g1_i5 O14662 STX16_HUMAN 6.00E-08 GO:0005794; GO:0000139; GO:0005484; GO:0031201; GO:0016021; GO:0006891; GO:0006886; GO:0005730; GO:0042147 "Golgi apparatus; Golgi membrane; SNAP receptor activity; SNARE complex; integral to membrane; intra-Golgi vesicle-mediated transport; intracellular protein transport; nucleolus; retrograde transport, endosome to Golgi" IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin-16 (Syn16) STX16 Homo sapiens (Human) TR39558_c0_g1_i6 Q54JY7 STX7A_DICDI 2.00E-18 GO:0030666; GO:0010008; GO:0008333; GO:0016021; GO:0006886; GO:0006906 Q75JI3; Q54NW7 endocytic vesicle membrane; endosome membrane; endosome to lysosome transport; integral to membrane; intracellular protein transport; vesicle fusion IPR006012; IPR010989; IPR000727; Syntaxin-7A syn7A syn7 DDB_G0287733 Dictyostelium discoideum (Slime mold) TR39558_c0_g1_i7 Q3ZBT5 STX7_BOVIN 2.00E-45 GO:0005484; GO:0000149; GO:0031201; GO:0031901; GO:0016021; GO:0006886; GO:0016079 SNAP receptor activity; SNARE binding; SNARE complex; early endosome membrane; integral to membrane; intracellular protein transport; synaptic vesicle exocytosis IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin-7 STX7 Bos taurus (Bovine) TR39558_c1_g1_i1 Q9P0M2 AKA7G_HUMAN 3.00E-10 GO:0016208; GO:0030315; GO:0016324; GO:0003824; GO:0005829; GO:0070382; GO:0008152; GO:0005634; GO:0043234; GO:0051018; GO:0010738; GO:0016529 AMP binding; T-tubule; apical plasma membrane; catalytic activity; cytosol; exocytic vesicle; metabolic process; nucleus; protein complex; protein kinase A binding; regulation of protein kinase A signaling cascade; sarcoplasmic reticulum IPR019510; IPR019511; IPR009097; A-kinase anchor protein 7 isoform gamma (AKAP-7 isoform gamma) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoform gamma) (PRKA7 isoform gamma) AKAP7 AKAP18 Homo sapiens (Human) TR39558_c1_g1_i3 Q9P0M2 AKA7G_HUMAN 2.00E-10 GO:0016208; GO:0030315; GO:0016324; GO:0003824; GO:0005829; GO:0070382; GO:0008152; GO:0005634; GO:0043234; GO:0051018; GO:0010738; GO:0016529 AMP binding; T-tubule; apical plasma membrane; catalytic activity; cytosol; exocytic vesicle; metabolic process; nucleus; protein complex; protein kinase A binding; regulation of protein kinase A signaling cascade; sarcoplasmic reticulum IPR019510; IPR019511; IPR009097; A-kinase anchor protein 7 isoform gamma (AKAP-7 isoform gamma) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoform gamma) (PRKA7 isoform gamma) AKAP7 AKAP18 Homo sapiens (Human) TR39559_c2_g2_i1 Q61XX9 RNC_CAEBR 6.00E-21 GO:0003723; GO:0030154; GO:0007506; GO:0046872; GO:0005634; GO:0031053; GO:0016075; GO:0006364; GO:0004525; GO:0019953 RNA binding; cell differentiation; gonadal mesoderm development; metal ion binding; nucleus; primary miRNA processing; rRNA catabolic process; rRNA processing; ribonuclease III activity; sexual reproduction IPR014720; IPR011907; IPR000999; Ribonuclease 3 (EC 3.1.26.3) (Protein drosha) (Ribonuclease III) (RNase III) drsh-1 CBG03798 Caenorhabditis briggsae TR39559_c2_g2_i2 Q9NRR4 RNC_HUMAN 7.00E-149 GO:0003723; GO:0010467; GO:0046872; GO:0010586; GO:0090305; GO:0005730; GO:0005654; GO:0031054; GO:0016075; GO:0004525; GO:0042254 Q8WYQ5; P35637 RNA binding; gene expression; metal ion binding; miRNA metabolic process; nucleic acid phosphodiester bond hydrolysis; nucleolus; nucleoplasm; pre-miRNA processing; rRNA catabolic process; ribonuclease III activity; ribosome biogenesis IPR014720; IPR011907; IPR000999; Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241) DROSHA RN3 RNASE3L RNASEN Homo sapiens (Human) TR39559_c2_g2_i4 Q310Z1 RNC_DESDG 4.00E-21 GO:0005737; GO:0006397; GO:0046872; GO:0090305; GO:0019843; GO:0016075; GO:0006364; GO:0004525; GO:0008033 cytoplasm; mRNA processing; metal ion binding; nucleic acid phosphodiester bond hydrolysis; rRNA binding; rRNA catabolic process; rRNA processing; ribonuclease III activity; tRNA processing IPR014720; IPR011907; IPR000999; Ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III) rnc Dde_1708 Desulfovibrio desulfuricans (strain G20) TR39559_c2_g5_i1 Q5HZJ0 RNC_MOUSE 4.00E-99 GO:0003723; GO:0004521; GO:0046872; GO:0010586; GO:0005730; GO:0031054; GO:0016075; GO:0004525; GO:0042254 RNA binding; endoribonuclease activity; metal ion binding; miRNA metabolic process; nucleolus; pre-miRNA processing; rRNA catabolic process; ribonuclease III activity; ribosome biogenesis IPR014720; IPR011907; IPR000999; Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) Drosha Etohi2 Rn3 Rnasen Mus musculus (Mouse) TR39562_c4_g1_i1 Q9NRH1 YAED1_HUMAN 1.00E-06 IPR019191; Yae1 domain-containing protein 1 YAE1D1 C7orf36 GK003 Homo sapiens (Human) TR39563_c0_g1_i1 A7SGU3 DCTN6_NEMVE 5.00E-65 GO:0005737; GO:0005869 cytoplasm; dynactin complex IPR027777; IPR011004; Dynactin subunit 6 dctn6 v1g170501 Nematostella vectensis (Starlet sea anemone) TR39563_c0_g1_i2 B1JBP8 LPXA_PSEPW 1.00E-08 GO:0008780; GO:0005737; GO:0009245 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity; cytoplasm; lipid A biosynthetic process IPR001451; IPR018357; IPR010137; IPR011004; Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (UDP-N-acetylglucosamine acyltransferase) (EC 2.3.1.129) lpxA PputW619_4070 Pseudomonas putida (strain W619) TR39563_c0_g1_i3 Q502J7 DCTN6_DANRE 4.00E-66 GO:0000777; GO:0005737; GO:0005869 condensed chromosome kinetochore; cytoplasm; dynactin complex IPR027777; IPR001451; IPR011004; Dynactin subunit 6 dctn6 zgc:112102 Danio rerio (Zebrafish) (Brachydanio rerio) TR39563_c0_g1_i5 O00399 DCTN6_HUMAN 1.00E-63 GO:0019886; GO:0005813; GO:0000777; GO:0005829; GO:0005869 antigen processing and presentation of exogenous peptide antigen via MHC class II; centrosome; condensed chromosome kinetochore; cytosol; dynactin complex IPR027777; IPR001451; IPR011004; Dynactin subunit 6 (Dynactin subunit p27) (Protein WS-3) DCTN6 WS3 Homo sapiens (Human) TR39564_c0_g1_i1 Q01433 AMPD2_HUMAN 0 GO:0003876; GO:0032264; GO:0005829; GO:0046872; GO:0006144; GO:0006163; GO:0043101 AMP deaminase activity; IMP salvage; cytosol; metal ion binding; purine nucleobase metabolic process; purine nucleotide metabolic process; purine-containing compound salvage IPR006650; IPR001365; IPR006329; Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1. AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L) AMPD2 Homo sapiens (Human) TR39564_c0_g1_i2 Q01433 AMPD2_HUMAN 0 GO:0003876; GO:0032264; GO:0005829; GO:0046872; GO:0006144; GO:0006163; GO:0043101 AMP deaminase activity; IMP salvage; cytosol; metal ion binding; purine nucleobase metabolic process; purine nucleotide metabolic process; purine-containing compound salvage IPR006650; IPR001365; IPR006329; Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1. AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L) AMPD2 Homo sapiens (Human) TR39565_c3_g1_i1 P04973 CLCA_BOVIN 3.00E-44 GO:0030132; GO:0030130; GO:0006886; GO:0005198; GO:0016192 clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; intracellular protein transport; structural molecule activity; vesicle-mediated transport IPR000996; Clathrin light chain A (Lca) CLTA Bos taurus (Bovine) TR39565_c3_g1_i3 O08585 CLCA_MOUSE 7.00E-44 GO:0030132; GO:0030130; GO:0016023; GO:0006886; GO:0005198; GO:0016192 clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; cytoplasmic membrane-bounded vesicle; intracellular protein transport; structural molecule activity; vesicle-mediated transport IPR000996; Clathrin light chain A (Lca) Clta Mus musculus (Mouse) TR39566_c2_g2_i1 P82987 ATL3_HUMAN 3.00E-64 GO:0008237; GO:0005578; GO:0008270 metallopeptidase activity; proteinaceous extracellular matrix; zinc ion binding IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013273; IPR010909; IPR000884; ADAMTS-like protein 3 (ADAMTSL-3) (Punctin-2) ADAMTSL3 KIAA1233 Homo sapiens (Human) TR39566_c2_g2_i3 Q8BLI0 ATL1_MOUSE 2.00E-62 GO:0008237; GO:0005578; GO:0008270 metallopeptidase activity; proteinaceous extracellular matrix; zinc ion binding IPR007110; IPR013783; IPR013098; IPR003598; IPR013273; IPR010909; IPR000884; ADAMTS-like protein 1 (ADAMTSL-1) (Punctin-1) Adamtsl1 Mus musculus (Mouse) TR39567_c0_g1_i3 Q8WVB3 HEXDC_HUMAN 4.00E-110 GO:0004563; GO:0005975; GO:0005737; GO:0005634 beta-N-acetylhexosaminidase activity; carbohydrate metabolic process; cytoplasm; nucleus IPR015883; IPR013781; IPR017853; Hexosaminidase D (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase D) (Hexosaminidase domain-containing protein) (N-acetyl-beta-galactosaminidase) HEXDC Homo sapiens (Human) TR39568_c2_g1_i1 Q8N8A2 ANR44_HUMAN 3.00E-06 Q9UPN7; P35125-3 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 Homo sapiens (Human) TR39568_c2_g1_i2 Q5DW34 EHMT1_MOUSE 1.00E-10 GO:0006306; GO:0005694; GO:0009790; GO:0046976; GO:0046974; GO:0000122; GO:0005634; GO:0018027; GO:0018026; GO:0008270 DNA methylation; chromosome; embryo development; histone methyltransferase activity (H3-K27 specific); histone methyltransferase activity (H3-K9 specific); negative regulation of transcription from RNA polymerase II promoter; nucleus; peptidyl-lysine dimethylation; peptidyl-lysine monomethylation; zinc ion binding IPR002110; IPR020683; IPR007728; IPR003606; IPR001214; Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Lysine N-methyltransferase 1D) Ehmt1 Euhmtase1 Glp Kmt1d Mus musculus (Mouse) TR39568_c2_g1_i3 Q8N8A2 ANR44_HUMAN 4.00E-06 Q9UPN7; P35125-3 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 Homo sapiens (Human) TR39568_c2_g1_i4 Q5DW34 EHMT1_MOUSE 9.00E-11 GO:0006306; GO:0005694; GO:0009790; GO:0046976; GO:0046974; GO:0000122; GO:0005634; GO:0018027; GO:0018026; GO:0008270 DNA methylation; chromosome; embryo development; histone methyltransferase activity (H3-K27 specific); histone methyltransferase activity (H3-K9 specific); negative regulation of transcription from RNA polymerase II promoter; nucleus; peptidyl-lysine dimethylation; peptidyl-lysine monomethylation; zinc ion binding IPR002110; IPR020683; IPR007728; IPR003606; IPR001214; Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Lysine N-methyltransferase 1D) Ehmt1 Euhmtase1 Glp Kmt1d Mus musculus (Mouse) TR39570_c2_g1_i1 Q5ZJA3 CDR2_CHICK 2.00E-28 GO:0005737 cytoplasm IPR026079; Cerebellar degeneration-related protein 2 CDR2 RCJMB04_19l3 Gallus gallus (Chicken) TR39571_c0_g1_i1 P11584 ITBX_DROME 0 GO:0007015; GO:0007475; GO:0007411; GO:0009925; GO:0007298; GO:0016339; GO:0016340; GO:0050839; GO:0031252; GO:0007417; GO:0008340; GO:0007391; GO:0035001; GO:0007427; GO:0007629; GO:0005925; GO:0007377; GO:0030718; GO:0035099; GO:0007157; GO:0048803; GO:0008305; GO:0007229; GO:0007508; GO:0016328; GO:0035160; GO:0007494; GO:0016203; GO:0030336; GO:0003344; GO:0004872; GO:0008360; GO:0051492; GO:0007431; GO:0007608; GO:0006930; GO:0007426; GO:0007601 "actin filament organization; apposition of dorsal and ventral imaginal disc-derived wing surfaces; axon guidance; basal plasma membrane; border follicle cell migration; calcium-dependent cell-cell adhesion; calcium-dependent cell-matrix adhesion; cell adhesion molecule binding; cell leading edge; central nervous system development; determination of adult lifespan; dorsal closure; dorsal trunk growth, open tracheal system; epithelial cell migration, open tracheal system; flight behavior; focal adhesion; germ-band extension; germ-line stem cell maintenance; hemocyte migration; heterophilic cell-cell adhesion; imaginal disc-derived male genitalia morphogenesis; integrin complex; integrin-mediated signaling pathway; larval heart development; lateral plasma membrane; maintenance of epithelial integrity, open tracheal system; midgut development; muscle attachment; negative regulation of cell migration; pericardium morphogenesis; receptor activity; regulation of cell shape; regulation of stress fiber assembly; salivary gland development; sensory perception of smell; substrate-dependent cell migration, cell extension; tracheal outgrowth, open tracheal system; visual perception" IPR000742; IPR013111; IPR015812; IPR014836; IPR002369; IPR012896; IPR016201; IPR002035; Integrin beta-PS (Position-specific antigen beta subunit) (Protein myospheroid) (Protein olfactory C) mys l(1)mys olfC CG1560 Drosophila melanogaster (Fruit fly) TR39571_c0_g1_i2 Q07441 ITB5_PAPCY 8.00E-138 GO:0007155; GO:0008305; GO:0007229; GO:0004872 cell adhesion; integrin complex; integrin-mediated signaling pathway; receptor activity IPR000742; IPR027067; IPR015812; IPR014836; IPR002369; IPR012896; IPR002035; Integrin beta-5 (Fragment) ITGB5 Papio cynocephalus (Yellow baboon) TR39571_c0_g1_i3 P11584 ITBX_DROME 0 GO:0007015; GO:0007475; GO:0007411; GO:0009925; GO:0007298; GO:0016339; GO:0016340; GO:0050839; GO:0031252; GO:0007417; GO:0008340; GO:0007391; GO:0035001; GO:0007427; GO:0007629; GO:0005925; GO:0007377; GO:0030718; GO:0035099; GO:0007157; GO:0048803; GO:0008305; GO:0007229; GO:0007508; GO:0016328; GO:0035160; GO:0007494; GO:0016203; GO:0030336; GO:0003344; GO:0004872; GO:0008360; GO:0051492; GO:0007431; GO:0007608; GO:0006930; GO:0007426; GO:0007601 "actin filament organization; apposition of dorsal and ventral imaginal disc-derived wing surfaces; axon guidance; basal plasma membrane; border follicle cell migration; calcium-dependent cell-cell adhesion; calcium-dependent cell-matrix adhesion; cell adhesion molecule binding; cell leading edge; central nervous system development; determination of adult lifespan; dorsal closure; dorsal trunk growth, open tracheal system; epithelial cell migration, open tracheal system; flight behavior; focal adhesion; germ-band extension; germ-line stem cell maintenance; hemocyte migration; heterophilic cell-cell adhesion; imaginal disc-derived male genitalia morphogenesis; integrin complex; integrin-mediated signaling pathway; larval heart development; lateral plasma membrane; maintenance of epithelial integrity, open tracheal system; midgut development; muscle attachment; negative regulation of cell migration; pericardium morphogenesis; receptor activity; regulation of cell shape; regulation of stress fiber assembly; salivary gland development; sensory perception of smell; substrate-dependent cell migration, cell extension; tracheal outgrowth, open tracheal system; visual perception" IPR000742; IPR013111; IPR015812; IPR014836; IPR002369; IPR012896; IPR016201; IPR002035; Integrin beta-PS (Position-specific antigen beta subunit) (Protein myospheroid) (Protein olfactory C) mys l(1)mys olfC CG1560 Drosophila melanogaster (Fruit fly) TR39571_c0_g1_i4 P12607 ITB1B_XENLA 0 GO:0007160; GO:0032154; GO:0008305; GO:0007229; GO:0030027; GO:0042470; GO:0007275; GO:0004872; GO:0001726 cell-matrix adhesion; cleavage furrow; integrin complex; integrin-mediated signaling pathway; lamellipodium; melanosome; multicellular organismal development; receptor activity; ruffle IPR013111; IPR027071; IPR015812; IPR014836; IPR002369; IPR012896; IPR016201; IPR002035; Integrin beta-1-B (Integrin beta-1*) itgb1-b Xenopus laevis (African clawed frog) TR39572_c1_g1_i5 Q91V92 ACLY_MOUSE 0 GO:0005524; GO:0003878; GO:0006085; GO:0044262; GO:0048037; GO:0008610; GO:0046872; GO:0005739; GO:0004775 Q8CFN5-4 ATP binding; ATP citrate synthase activity; acetyl-CoA biosynthetic process; cellular carbohydrate metabolic process; cofactor binding; lipid biosynthetic process; metal ion binding; mitochondrion; succinate-CoA ligase (ADP-forming) activity IPR014608; IPR013650; IPR013816; IPR017440; IPR016143; IPR002020; IPR016141; IPR003781; IPR005810; IPR005811; IPR016040; IPR017866; IPR016102; ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme) Acly Mus musculus (Mouse) TR39572_c1_g1_i6 Q91V92 ACLY_MOUSE 0 GO:0005524; GO:0003878; GO:0006085; GO:0044262; GO:0048037; GO:0008610; GO:0046872; GO:0005739; GO:0004775 Q8CFN5-4 ATP binding; ATP citrate synthase activity; acetyl-CoA biosynthetic process; cellular carbohydrate metabolic process; cofactor binding; lipid biosynthetic process; metal ion binding; mitochondrion; succinate-CoA ligase (ADP-forming) activity IPR014608; IPR013650; IPR013816; IPR017440; IPR016143; IPR002020; IPR016141; IPR003781; IPR005810; IPR005811; IPR016040; IPR017866; IPR016102; ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme) Acly Mus musculus (Mouse) TR39572_c1_g4_i1 Q91V92 ACLY_MOUSE 6.00E-25 GO:0005524; GO:0003878; GO:0006085; GO:0044262; GO:0048037; GO:0008610; GO:0046872; GO:0005739; GO:0004775 Q8CFN5-4 ATP binding; ATP citrate synthase activity; acetyl-CoA biosynthetic process; cellular carbohydrate metabolic process; cofactor binding; lipid biosynthetic process; metal ion binding; mitochondrion; succinate-CoA ligase (ADP-forming) activity IPR014608; IPR013650; IPR013816; IPR017440; IPR016143; IPR002020; IPR016141; IPR003781; IPR005810; IPR005811; IPR016040; IPR017866; IPR016102; ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme) Acly Mus musculus (Mouse) TR39573_c1_g1_i1 P34714 SPRC_CAEEL 4.00E-51 GO:0005604; GO:0005509; GO:0005615; GO:0007275; GO:0007165 basement membrane; calcium ion binding; extracellular space; multicellular organismal development; signal transduction IPR011992; IPR018247; IPR003645; IPR015369; IPR002350; IPR001999; IPR019577; SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine) ost-1 sparc C44B12.2 Caenorhabditis elegans TR39573_c1_g1_i3 Q14515 SPRL1_HUMAN 3.00E-26 GO:0005509; GO:0005615; GO:0005578; GO:0007165 calcium ion binding; extracellular space; proteinaceous extracellular matrix; signal transduction IPR011992; IPR018247; IPR002048; IPR003645; IPR015369; IPR002350; IPR001999; IPR016359; IPR019577; SPARC-like protein 1 (High endothelial venule protein) (Hevin) (MAST 9) SPARCL1 Homo sapiens (Human) TR39573_c1_g1_i5 P34714 SPRC_CAEEL 1.00E-50 GO:0005604; GO:0005509; GO:0005615; GO:0007275; GO:0007165 basement membrane; calcium ion binding; extracellular space; multicellular organismal development; signal transduction IPR011992; IPR018247; IPR003645; IPR015369; IPR002350; IPR001999; IPR019577; SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine) ost-1 sparc C44B12.2 Caenorhabditis elegans TR39574_c1_g2_i1 O93257 XRCC6_CHICK 1.00E-124 GO:0051575; GO:0005524; GO:0004003; GO:0006310; GO:0043564; GO:0005694; GO:0003684; GO:0006303; GO:0045892; GO:0070419; GO:0005654; GO:0000723; GO:0042162; GO:0006351 "5'-deoxyribose-5-phosphate lyase activity; ATP binding; ATP-dependent DNA helicase activity; DNA recombination; Ku70:Ku80 complex; chromosome; damaged DNA binding; double-strand break repair via nonhomologous end joining; negative regulation of transcription, DNA-dependent; nonhomologous end joining complex; nucleoplasm; telomere maintenance; telomeric DNA binding; transcription, DNA-dependent" IPR006165; IPR006164; IPR027388; IPR005160; IPR005161; IPR003034; IPR016194; IPR002035; X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP/AP lyase Ku70) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (DNA repair protein XRCC6) (Ku autoantigen protein p70 homolog) (Ku70) XRCC6 G22P1 KU70 Gallus gallus (Chicken) TR39575_c5_g1_i1 A2AJ76 HMCN2_MOUSE 2.00E-06 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 Hmcn2 Mus musculus (Mouse) TR39577_c0_g2_i1 Q9P2E5 CHPF2_HUMAN 3.00E-90 GO:0032580; GO:0000139; GO:0050510; GO:0005975; GO:0030206; GO:0016021 Golgi cisterna membrane; Golgi membrane; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity; carbohydrate metabolic process; chondroitin sulfate biosynthetic process; integral to membrane IPR008428; Chondroitin sulfate glucuronyltransferase (EC 2.4.1.226) (CSGlcA-T) (Chondroitin glucuronyltransferase) (Chondroitin polymerizing factor 2) (ChPF-2) (Chondroitin synthase 3) (ChSy-3) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase) CHPF2 CHSY3 CSGLCAT KIAA1402 UNQ299/PRO339 Homo sapiens (Human) TR39578_c1_g1_i1 Q14188 TFDP2_HUMAN 3.00E-66 GO:0003677; GO:0007507; GO:0000278; GO:0005654; GO:0045944; GO:0003700; GO:0003712; GO:0005667; GO:0006367; GO:0007179 DNA binding; heart development; mitotic cell cycle; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription cofactor activity; transcription factor complex; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway IPR028314; IPR003316; IPR014889; IPR015648; IPR011991; Transcription factor Dp-2 (E2F dimerization partner 2) TFDP2 DP2 Homo sapiens (Human) TR39579_c0_g1_i2 Q28EW0 TM87A_XENTR 4.00E-134 GO:0016021 integral to membrane IPR009637; Transmembrane protein 87A tmem87a TGas047b06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39580_c0_g1_i1 Q04737 Y751_SYNY3 2.00E-09 IPR013026; IPR011990; IPR001440; IPR013105; IPR019734; TPR repeat-containing protein slr0751 slr0751 Synechocystis sp. (strain PCC 6803 / Kazusa) TR39580_c0_g1_i2 Q8NBP0 TTC13_HUMAN 7.00E-113 IPR013026; IPR011990; IPR019734; Tetratricopeptide repeat protein 13 (TPR repeat protein 13) TTC13 PSEC0076 Homo sapiens (Human) TR39581_c2_g2_i1 Q86WC6 PPR27_HUMAN 1.00E-27 GO:0010923; GO:0019902; GO:0004864 P62136 negative regulation of phosphatase activity; phosphatase binding; protein phosphatase inhibitor activity IPR002110; IPR020683; Protein phosphatase 1 regulatory subunit 27 (Dysferlin-interacting protein 1) (Toonin) PPP1R27 DYSFIP1 Homo sapiens (Human) TR39581_c2_g2_i2 Q9QZH2 BARD1_RAT 9.00E-12 GO:0031436; GO:0006281; GO:0005737; GO:0016874; GO:0043066; GO:0046826; GO:0043065; GO:0085020; GO:0042803; GO:0042325; GO:0007283; GO:0008270 BRCA1-BARD1 complex; DNA repair; cytoplasm; ligase activity; negative regulation of apoptotic process; negative regulation of protein export from nucleus; positive regulation of apoptotic process; protein K6-linked ubiquitination; protein homodimerization activity; regulation of phosphorylation; spermatogenesis; zinc ion binding IPR002110; IPR020683; IPR001357; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. BRCA1-associated RING domain protein 1 (BARD-1) (EC 6.3.2.-) Bard1 Rattus norvegicus (Rat) TR39581_c2_g2_i3 Q8BG95 MYPT2_MOUSE 4.00E-22 GO:0005737 cytoplasm IPR002110; IPR020683; IPR017401; Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) Ppp1r12b Mypt2 Mus musculus (Mouse) TR39581_c2_g2_i4 Q9DBR7 MYPT1_MOUSE 1.00E-17 GO:0071889; GO:0072357; GO:0005813; GO:0051297; GO:0043292; GO:0004857; GO:0000776; GO:0007067; GO:0019208; GO:0045944; GO:0006470; GO:0030155; GO:0035507; GO:0046822 14-3-3 protein binding; PTW/PP1 phosphatase complex; centrosome; centrosome organization; contractile fiber; enzyme inhibitor activity; kinetochore; mitosis; phosphatase regulator activity; positive regulation of transcription from RNA polymerase II promoter; protein dephosphorylation; regulation of cell adhesion; regulation of myosin-light-chain-phosphatase activity; regulation of nucleocytoplasmic transport IPR002110; IPR020683; IPR017401; Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) Ppp1r12a Mypt1 Mus musculus (Mouse) TR39581_c2_g2_i5 Q86WC6 PPR27_HUMAN 1.00E-28 GO:0010923; GO:0019902; GO:0004864 P62136 negative regulation of phosphatase activity; phosphatase binding; protein phosphatase inhibitor activity IPR002110; IPR020683; Protein phosphatase 1 regulatory subunit 27 (Dysferlin-interacting protein 1) (Toonin) PPP1R27 DYSFIP1 Homo sapiens (Human) TR39583_c1_g1_i3 A2A6C4 SPP2C_MOUSE 6.00E-25 GO:0004190; GO:0071458; GO:0071556; GO:0042803; GO:0006508 aspartic-type endopeptidase activity; integral to cytosolic side of endoplasmic reticulum membrane; integral to lumenal side of endoplasmic reticulum membrane; protein homodimerization activity; proteolysis IPR007369; IPR006639; IPR003137; Signal peptide peptidase-like 2C (SPP-like 2C) (SPPL2c) (EC 3.4.23.-) (Intramembrane protease 5) (IMP-5) Sppl2c Imp5 Mus musculus (Mouse) TR39583_c1_g1_i6 Q8IUH8 SPP2C_HUMAN 4.00E-20 GO:0004190; GO:0071458; GO:0071556; GO:0042803; GO:0006508 aspartic-type endopeptidase activity; integral to cytosolic side of endoplasmic reticulum membrane; integral to lumenal side of endoplasmic reticulum membrane; protein homodimerization activity; proteolysis IPR007369; IPR006639; IPR003137; Signal peptide peptidase-like 2C (SPP-like 2C) (SPPL2c) (EC 3.4.23.-) (Intramembrane protease 5) (IMP-5) SPPL2C IMP5 Homo sapiens (Human) TR39583_c1_g1_i8 Q5N808 SIPL3_ORYSJ 3.00E-09 GO:0004190; GO:0010008; GO:0016021; GO:0006508 aspartic-type endopeptidase activity; endosome membrane; integral to membrane; proteolysis IPR007369; IPR006639; IPR003137; Signal peptide peptidase-like 3 (OsSPPL3) (EC 3.4.23.-) SPPL3 Os01g0914700 LOC_Os01g68620 OsJ_04526 P0004D12.11 Oryza sativa subsp. japonica (Rice) TR39583_c1_g2_i1 Q5F383 SPP2B_CHICK 1.00E-39 GO:0030660; GO:0042500; GO:0010008; GO:0071458; GO:0071556; GO:0005765; GO:0006509; GO:0031293; GO:0005886; GO:0042803; GO:0050776 "Golgi-associated vesicle membrane; aspartic endopeptidase activity, intramembrane cleaving; endosome membrane; integral to cytosolic side of endoplasmic reticulum membrane; integral to lumenal side of endoplasmic reticulum membrane; lysosomal membrane; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; plasma membrane; protein homodimerization activity; regulation of immune response" IPR007369; IPR006639; IPR003137; Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) SPPL2B RCJMB04_29c5 Gallus gallus (Chicken) TR39583_c1_g2_i2 Q0WMJ8 SIPL4_ARATH 7.00E-13 GO:0004190; GO:0010008; GO:0016021; GO:0006508 aspartic-type endopeptidase activity; endosome membrane; integral to membrane; proteolysis IPR007369; IPR006639; IPR003137; Signal peptide peptidase-like 4 (AtSPPL4) (EC 3.4.23.-) SPPL4 At1g01650 T1N6.3 Arabidopsis thaliana (Mouse-ear cress) TR39583_c1_g2_i3 Q5F383 SPP2B_CHICK 9.00E-21 GO:0030660; GO:0042500; GO:0010008; GO:0071458; GO:0071556; GO:0005765; GO:0006509; GO:0031293; GO:0005886; GO:0042803; GO:0050776 "Golgi-associated vesicle membrane; aspartic endopeptidase activity, intramembrane cleaving; endosome membrane; integral to cytosolic side of endoplasmic reticulum membrane; integral to lumenal side of endoplasmic reticulum membrane; lysosomal membrane; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; plasma membrane; protein homodimerization activity; regulation of immune response" IPR007369; IPR006639; IPR003137; Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) SPPL2B RCJMB04_29c5 Gallus gallus (Chicken) TR39584_c2_g2_i2 Q52353 TERZ_SERMA 1.00E-06 GO:0006950; GO:0046690 response to stress; response to tellurium ion IPR003325; Tellurium resistance protein TerZ terZ Serratia marcescens TR39584_c3_g1_i1 Q3TQQ9 CA112_MOUSE 2.00E-44 IPR027902; Uncharacterized protein C1orf112 homolog Mus musculus (Mouse) TR39584_c3_g1_i2 Q9NSG2 CA112_HUMAN 4.00E-49 IPR027902; Uncharacterized protein C1orf112 C1orf112 Homo sapiens (Human) TR39585_c3_g2_i2 P48300 FUCO_CANFA 4.00E-83 GO:0004560; GO:0006004; GO:0005764 alpha-L-fucosidase activity; fucose metabolic process; lysosome IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) FUCA1 Canis familiaris (Dog) (Canis lupus familiaris) TR39585_c3_g2_i4 Q6AYS4 FUCO2_RAT 9.00E-89 GO:0004560; GO:0005975; GO:0005576; GO:0042806; GO:0006004; GO:0005764 alpha-L-fucosidase activity; carbohydrate metabolic process; extracellular region; fucose binding; fucose metabolic process; lysosome IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2) Fuca2 Rattus norvegicus (Rat) TR39585_c3_g2_i5 C3YWU0 FUCO_BRAFL 3.00E-96 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR39586_c1_g1_i1 P34545 CBP1_CAEEL 4.00E-138 GO:0005737; GO:0009790; GO:0004402; GO:0004468; GO:0005634; GO:0045944; GO:0007283; GO:0003712; GO:0008270 cytoplasm; embryo development; histone acetyltransferase activity; lysine N-acetyltransferase activity; nucleus; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; transcription cofactor activity; zinc ion binding IPR001487; IPR018359; IPR010303; IPR013178; IPR003101; IPR000197; IPR000433; Protein cbp-1 cbp-1 R10E11.1 Caenorhabditis elegans TR39586_c1_g1_i2 Q6JHU9 CBP_RAT 0 GO:0043426; GO:0008283; GO:0005737; GO:0004402; GO:0000123; GO:0005634; GO:0042975; GO:0045944; GO:0003713; GO:0005667; GO:0006351; GO:0008270 "MRF binding; cell proliferation; cytoplasm; histone acetyltransferase activity; histone acetyltransferase complex; nucleus; peroxisome proliferator activated receptor binding; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcription factor complex; transcription, DNA-dependent; zinc ion binding" IPR001487; IPR018359; IPR010303; IPR013178; IPR003101; IPR009110; IPR014744; IPR000197; IPR000433; CREB-binding protein (EC 2.3.1.48) Crebbp Cbp Rattus norvegicus (Rat) TR39586_c1_g1_i4 Q6JHU9 CBP_RAT 0 GO:0043426; GO:0008283; GO:0005737; GO:0004402; GO:0000123; GO:0005634; GO:0042975; GO:0045944; GO:0003713; GO:0005667; GO:0006351; GO:0008270 "MRF binding; cell proliferation; cytoplasm; histone acetyltransferase activity; histone acetyltransferase complex; nucleus; peroxisome proliferator activated receptor binding; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcription factor complex; transcription, DNA-dependent; zinc ion binding" IPR001487; IPR018359; IPR010303; IPR013178; IPR003101; IPR009110; IPR014744; IPR000197; IPR000433; CREB-binding protein (EC 2.3.1.48) Crebbp Cbp Rattus norvegicus (Rat) TR39586_c1_g1_i5 P34545 CBP1_CAEEL 4.00E-138 GO:0005737; GO:0009790; GO:0004402; GO:0004468; GO:0005634; GO:0045944; GO:0007283; GO:0003712; GO:0008270 cytoplasm; embryo development; histone acetyltransferase activity; lysine N-acetyltransferase activity; nucleus; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; transcription cofactor activity; zinc ion binding IPR001487; IPR018359; IPR010303; IPR013178; IPR003101; IPR000197; IPR000433; Protein cbp-1 cbp-1 R10E11.1 Caenorhabditis elegans TR39586_c1_g3_i1 Q6JHU9 CBP_RAT 8.00E-45 GO:0043426; GO:0008283; GO:0005737; GO:0004402; GO:0000123; GO:0005634; GO:0042975; GO:0045944; GO:0003713; GO:0005667; GO:0006351; GO:0008270 "MRF binding; cell proliferation; cytoplasm; histone acetyltransferase activity; histone acetyltransferase complex; nucleus; peroxisome proliferator activated receptor binding; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcription factor complex; transcription, DNA-dependent; zinc ion binding" IPR001487; IPR018359; IPR010303; IPR013178; IPR003101; IPR009110; IPR014744; IPR000197; IPR000433; CREB-binding protein (EC 2.3.1.48) Crebbp Cbp Rattus norvegicus (Rat) TR39587_c0_g1_i2 Q62463 V1AR_MOUSE 5.00E-20 GO:0019722; GO:0042631; GO:0031410; GO:0007204; GO:0007625; GO:0016021; GO:0002125; GO:0042711; GO:0014902; GO:0007621; GO:0051970; GO:0043084; GO:0017046; GO:0005886; GO:0030307; GO:0008284; GO:0032849; GO:0014049; GO:0010460; GO:0031394; GO:0035815; GO:0003084; GO:0045907; GO:0001992; GO:0051412; GO:0035176; GO:0042713; GO:0021537; GO:0005000 calcium-mediated signaling; cellular response to water deprivation; cytoplasmic vesicle; elevation of cytosolic calcium ion concentration; grooming behavior; integral to membrane; maternal aggressive behavior; maternal behavior; myotube differentiation; negative regulation of female receptivity; negative regulation of transmission of nerve impulse; penile erection; peptide hormone binding; plasma membrane; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cellular pH reduction; positive regulation of glutamate secretion; positive regulation of heart rate; positive regulation of prostaglandin biosynthetic process; positive regulation of renal sodium excretion; positive regulation of systemic arterial blood pressure; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure by vasopressin; response to corticosterone stimulus; social behavior; sperm ejaculation; telencephalon development; vasopressin receptor activity IPR015076; IPR000276; IPR017452; IPR001817; IPR001224; Vasopressin V1a receptor (V1aR) (AVPR V1a) (Antidiuretic hormone receptor 1a) (Vascular/hepatic-type arginine vasopressin receptor) Avpr1a Mus musculus (Mouse) TR39587_c0_g1_i4 Q28756 OXYR_SHEEP 1.00E-10 GO:0016021; GO:0004990; GO:0005886; GO:0005000 integral to membrane; oxytocin receptor activity; plasma membrane; vasopressin receptor activity IPR000276; IPR017452; IPR002062; IPR001817; Oxytocin receptor (OT-R) OXTR Ovis aries (Sheep) TR39587_c0_g1_i5 P48974 V1BR_RAT 4.00E-14 GO:0007188; GO:0007204; GO:0042538; GO:0016021; GO:0017046; GO:0005886; GO:0045777; GO:0032849; GO:0014049; GO:0010460; GO:0042803; GO:0005000 adenylate cyclase-modulating G-protein coupled receptor signaling pathway; elevation of cytosolic calcium ion concentration; hyperosmotic salinity response; integral to membrane; peptide hormone binding; plasma membrane; positive regulation of blood pressure; positive regulation of cellular pH reduction; positive regulation of glutamate secretion; positive regulation of heart rate; protein homodimerization activity; vasopressin receptor activity IPR015076; IPR000276; IPR017452; IPR001817; IPR000628; Vasopressin V1b receptor (V1bR) (AVPR V1b) (AVPR V3) (Antidiuretic hormone receptor 1b) (Vasopressin V3 receptor) Avpr1b Rattus norvegicus (Rat) TR39588_c4_g1_i2 Q86VS8 HOOK3_HUMAN 1.00E-125 GO:0070695; GO:0005794; GO:0051645; GO:0034451; GO:0005801; GO:0031122; GO:0045022; GO:0007032; GO:0008333; GO:0022027; GO:0007040; GO:0005874; GO:0034454; GO:0008017; GO:0050768; GO:0097150; GO:0000242; GO:0071539; GO:0015031 P21757 FHF complex; Golgi apparatus; Golgi localization; centriolar satellite; cis-Golgi network; cytoplasmic microtubule organization; early endosome to late endosome transport; endosome organization; endosome to lysosome transport; interkinetic nuclear migration; lysosome organization; microtubule; microtubule anchoring at centrosome; microtubule binding; negative regulation of neurogenesis; neuronal stem cell maintenance; pericentriolar material; protein localization to centrosome; protein transport IPR008636; Protein Hook homolog 3 (h-hook3) (hHK3) HOOK3 Homo sapiens (Human) TR39588_c4_g2_i1 Q6GQ73 HOOK3_XENLA 2.00E-42 GO:0005794; GO:0045022; GO:0007032; GO:0008333; GO:0007040; GO:0005874; GO:0015031 Golgi apparatus; early endosome to late endosome transport; endosome organization; endosome to lysosome transport; lysosome organization; microtubule; protein transport IPR008636; Protein Hook homolog 3 hook3 Xenopus laevis (African clawed frog) TR39589_c1_g2_i1 Q5EHU7 ERGI2_GECJA 2.00E-111 GO:0005794; GO:0005789; GO:0033116; GO:0016021; GO:0016192 Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; vesicle-mediated transport IPR012936; Endoplasmic reticulum-Golgi intermediate compartment protein 2 ERGIC2 GekBS204P Gecko japonicus (Japanese gecko) TR39589_c1_g2_i4 P39727 ERV46_YEAST 2.00E-17 GO:0030134; GO:0006888; GO:0030173; GO:0030176; GO:0015031 Q04651 ER to Golgi transport vesicle; ER to Golgi vesicle-mediated transport; integral to Golgi membrane; integral to endoplasmic reticulum membrane; protein transport IPR012936; ER-derived vesicles protein ERV46 ERV46 YAL042W FUN9 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39591_c1_g1_i1 P91924 ARF_DUGJA 2.00E-63 GO:0005525; GO:0005794; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor Dugesia japonica (Planarian) TR39591_c1_g1_i2 P36410 RAB14_DICDI 3.00E-06 GO:0005525; GO:0000331; GO:0005768; GO:0005764; GO:0016020; GO:0045335; GO:0015031; GO:0007264 GTP binding; contractile vacuole; endosome; lysosome; membrane; phagocytic vesicle; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-14 (Rab4-like GTPase) rab14 rab4 rabD DDB_G0281337 Dictyostelium discoideum (Slime mold) TR39591_c2_g1_i1 Q04864 REL_HUMAN 4.00E-06 GO:0003677; GO:0001816; GO:0005829; GO:0005654; GO:0043123; GO:0045084; GO:0045893; GO:0003700; GO:0006351 Q8N668 "DNA binding; cytokine production; cytosol; nucleoplasm; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 biosynthetic process; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR013783; IPR014756; IPR002909; IPR000451; IPR008967; IPR011539; Proto-oncogene c-Rel REL Homo sapiens (Human) TR39591_c2_g1_i6 Q04864 REL_HUMAN 4.00E-06 GO:0003677; GO:0001816; GO:0005829; GO:0005654; GO:0043123; GO:0045084; GO:0045893; GO:0003700; GO:0006351 Q8N668 "DNA binding; cytokine production; cytosol; nucleoplasm; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 biosynthetic process; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR013783; IPR014756; IPR002909; IPR000451; IPR008967; IPR011539; Proto-oncogene c-Rel REL Homo sapiens (Human) TR39592_c0_g1_i1 Q5IS41 NCAN_PANTR 6.00E-23 GO:0005509; GO:0030246; GO:0007155; GO:0005576; GO:0005540 calcium ion binding; carbohydrate binding; cell adhesion; extracellular region; hyaluronic acid binding IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Neurocan core protein (Chondroitin sulfate proteoglycan 3) NCAN CSPG3 Pan troglodytes (Chimpanzee) TR39592_c0_g1_i2 Q5UQ13 COLL2_MIMIV 2.00E-25 GO:0005581; GO:0019012 collagen; virion IPR008160; Collagen-like protein 2 MIMI_R196 Acanthamoeba polyphaga mimivirus (APMV) TR39592_c0_g1_i3 P86854 PLCL_MYTGA 2.00E-18 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR39593_c0_g1_i2 P24014 SLIT_DROME 6.00E-06 GO:0035385; GO:0071666; GO:0016199; GO:0005509; GO:0048813; GO:0007502; GO:0035050; GO:0007427; GO:0008347; GO:0008406; GO:0008201; GO:0050929; GO:0046331; GO:0008078; GO:0001764; GO:0003151; GO:0005886; GO:0022409; GO:0005578; GO:2000274; GO:0007432 "Roundabout signaling pathway; Slit-Robo signaling complex; axon midline choice point recognition; calcium ion binding; dendrite morphogenesis; digestive tract mesoderm development; embryonic heart tube development; epithelial cell migration, open tracheal system; glial cell migration; gonad development; heparin binding; induction of negative chemotaxis; lateral inhibition; mesodermal cell migration; neuron migration; outflow tract morphogenesis; plasma membrane; positive regulation of cell-cell adhesion; proteinaceous extracellular matrix; regulation of epithelial cell migration, open tracheal system; salivary gland boundary specification" IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; IPR026906; Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) TR39593_c0_g2_i1 Q86VH4 LRRT4_HUMAN 3.00E-06 GO:0032281; GO:0030054; GO:0045211 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; cell junction; postsynaptic membrane IPR001611; IPR003591; IPR000372; Leucine-rich repeat transmembrane neuronal protein 4 LRRTM4 UNQ3075/PRO9907 Homo sapiens (Human) TR39593_c0_g2_i2 Q9Z2H4 LGR4_RAT 5.00E-09 GO:0007186; GO:0016055; GO:0030282; GO:0046849; GO:0045087; GO:0005887; GO:0050710; GO:0034122; GO:0001649; GO:0090263; GO:0007283; GO:0004888 G-protein coupled receptor signaling pathway; Wnt receptor signaling pathway; bone mineralization; bone remodeling; innate immune response; integral to plasma membrane; negative regulation of cytokine secretion; negative regulation of toll-like receptor signaling pathway; osteoblast differentiation; positive regulation of canonical Wnt receptor signaling pathway; spermatogenesis; transmembrane signaling receptor activity IPR000276; IPR017452; IPR002131; IPR001611; IPR025875; IPR003591; IPR000372; Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48) Lgr4 Gpr48 Rattus norvegicus (Rat) TR39594_c1_g1_i1 A6QR55 UBP4_BOVIN 1.00E-33 GO:0005737; GO:0046872; GO:0031397; GO:0005634; GO:0016579; GO:0034394; GO:0031647; GO:0004221; GO:0006511; GO:0004843 cytoplasm; metal ion binding; negative regulation of protein ubiquitination; nucleus; protein deubiquitination; protein localization to cell surface; regulation of protein stability; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR006615; IPR018200; IPR001394; IPR028135; IPR028134; Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) USP4 Bos taurus (Bovine) TR39594_c1_g2_i1 P35125 UBP6_HUMAN 7.00E-14 GO:0005097; GO:0004197; GO:0005764; GO:0003676; GO:0005886; GO:0032851; GO:0016579; GO:0055037; GO:0060627; GO:0004221; GO:0006511; GO:0004843 Q8N8A2; P10916 Rab GTPase activator activity; cysteine-type endopeptidase activity; lysosome; nucleic acid binding; plasma membrane; positive regulation of Rab GTPase activity; protein deubiquitination; recycling endosome; regulation of vesicle-mediated transport; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR018200; IPR001394; IPR000195; Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) USP6 HRP1 TRE2 Homo sapiens (Human) TR39594_c1_g2_i2 Q8W4N3 UBP2_ARATH 1.00E-08 GO:0009507; GO:0008234; GO:0000502; GO:0004221; GO:0006511; GO:0008270 chloroplast; cysteine-type peptidase activity; proteasome complex; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; zinc ion binding IPR018200; IPR001394; IPR013083; IPR001607; Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (Deubiquitinating enzyme 2) (AtUBP2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) UBP2 At1g04860 F13M7.15 Arabidopsis thaliana (Mouse-ear cress) TR39597_c2_g1_i1 Q5TJG6 BRD2_CANFA 3.00E-121 GO:0003682; GO:0016568; GO:0005737; GO:0070577; GO:0006334; GO:0005634; GO:0006357; GO:0006351 "chromatin binding; chromatin modification; cytoplasm; histone acetyl-lysine binding; nucleosome assembly; nucleus; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR001487; IPR018359; IPR027353; Bromodomain-containing protein 2 BRD2 Canis familiaris (Dog) (Canis lupus familiaris) TR39597_c2_g1_i2 Q4R8Y1 BRDT_MACFA 6.00E-99 GO:0008380; GO:0030154; GO:0006338; GO:0070577; GO:0001207; GO:0006397; GO:0007141; GO:0005634; GO:0051039; GO:0043484; GO:0007283; GO:0006351 "RNA splicing; cell differentiation; chromatin remodeling; histone acetyl-lysine binding; histone displacement; mRNA processing; male meiosis I; nucleus; positive regulation of transcription during meiosis; regulation of RNA splicing; spermatogenesis; transcription, DNA-dependent" IPR001487; IPR018359; IPR027353; Bromodomain testis-specific protein BRDT QtsA-11165 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR39597_c2_g2_i1 P13709 FSH_DROME 1.00E-38 GO:0007476; GO:0016021; GO:0045892; GO:0007362 "imaginal disc-derived wing morphogenesis; integral to membrane; negative regulation of transcription, DNA-dependent; terminal region determination" IPR001487; IPR018359; IPR027353; Homeotic protein female sterile (Fragile-chorion membrane protein) fs(1)h fsh CG2252 Drosophila melanogaster (Fruit fly) TR39598_c0_g1_i2 Q8BMQ3 BNC2_MOUSE 5.00E-65 GO:0003677; GO:0005737; GO:0003416; GO:0060485; GO:0046872; GO:0005634; GO:0060021; GO:0005886; GO:0006355; GO:0043586; GO:0006351 "DNA binding; cytoplasm; endochondral bone growth; mesenchyme development; metal ion binding; nucleus; palate development; plasma membrane; regulation of transcription, DNA-dependent; tongue development; transcription, DNA-dependent" IPR007087; IPR015880; Zinc finger protein basonuclin-2 Bnc2 Mus musculus (Mouse) TR39598_c0_g1_i3 Q6ZN30 BNC2_HUMAN 8.00E-12 GO:0003677; GO:0005737; GO:0046872; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "DNA binding; cytoplasm; metal ion binding; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; Zinc finger protein basonuclin-2 BNC2 Homo sapiens (Human) TR39600_c0_g1_i1 Q6UWE0 LRSM1_HUMAN 9.00E-84 GO:0005737; GO:0005576; GO:0016020; GO:0045806; GO:0051865; GO:0030163; GO:0000209; GO:0015031; GO:0070086; GO:0004842; GO:0046755; GO:0008270 cytoplasm; extracellular region; membrane; negative regulation of endocytosis; protein autoubiquitination; protein catabolic process; protein polyubiquitination; protein transport; ubiquitin-dependent endocytosis; ubiquitin-protein ligase activity; viral budding; zinc ion binding IPR016179; IPR001611; IPR025875; IPR001660; IPR013761; IPR011510; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL) LRSAM1 TAL UNQ6496/PRO21356 Homo sapiens (Human) TR39600_c0_g1_i2 Q7SXW3 LRC40_DANRE 2.00E-15 IPR001611; IPR025875; IPR003591; Leucine-rich repeat-containing protein 40 lrrc40 zgc:63729 Danio rerio (Zebrafish) (Brachydanio rerio) TR39602_c1_g1_i1 O15213 WDR46_HUMAN 6.00E-132 IPR012952; IPR015943; IPR001680; IPR017986; WD repeat-containing protein 46 (WD repeat-containing protein BING4) WDR46 BING4 C6orf11 FP221 Homo sapiens (Human) TR39602_c2_g1_i1 A0PJR5 ECHD3_DANRE 2.00E-07 GO:0003824; GO:0005739 catalytic activity; mitochondrion IPR014748; IPR001753; "Enoyl-CoA hydratase domain-containing protein 3, mitochondrial" echdc3 zgc:158321 Danio rerio (Zebrafish) (Brachydanio rerio) TR39602_c2_g1_i2 P53526 ECH12_MYCLE 7.00E-14 GO:0004300; GO:0006631 enoyl-CoA hydratase activity; fatty acid metabolic process IPR001753; IPR018376; Probable enoyl-CoA hydratase echA12 (EC 4.2.1.17) echA12 ML1241 B1170_C2_224 MLCB1610.01 Mycobacterium leprae (strain TN) TR39602_c2_g2_i2 Q62651 ECH1_RAT 2.00E-77 GO:0006635; GO:0016853; GO:0046872; GO:0005739; GO:0005777 fatty acid beta-oxidation; isomerase activity; metal ion binding; mitochondrion; peroxisome IPR014748; IPR001753; IPR018376; Lipid metabolism; fatty acid beta-oxidation. "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-)" Ech1 Rattus norvegicus (Rat) TR39603_c1_g2_i1 Q8TD19 NEK9_HUMAN 9.00E-09 GO:0005524; GO:0051301; GO:0005829; GO:0046872; GO:0005739; GO:0007067; GO:0007077; GO:0005634; GO:0004674 O95166; Q9H0R8; P60520; P08238; Q9GZQ8; Q9BXW4; P53350 ATP binding; cell division; cytosol; metal ion binding; mitochondrion; mitosis; mitotic nuclear envelope disassembly; nucleus; protein serine/threonine kinase activity IPR011009; IPR000719; IPR009091; IPR000408; IPR002290; IPR008271; Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) NEK9 KIAA1995 NEK8 NERCC Homo sapiens (Human) TR39603_c1_g5_i1 Q8TE73 DYH5_HUMAN 3.00E-70 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 5, axonemal (Axonemal beta dynein heavy chain 5) (Ciliary dynein heavy chain 5)" DNAH5 DNAHC5 HL1 KIAA1603 Homo sapiens (Human) TR39603_c2_g1_i1 Q29558 MAOX_PIG 1.00E-112 GO:0051287; GO:0005829; GO:0004473; GO:0016619; GO:0006108; GO:0030145; GO:0009725 NAD binding; cytosol; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity; malate dehydrogenase (oxaloacetate-decarboxylating) activity; malate metabolic process; manganese ion binding; response to hormone stimulus IPR015884; IPR012301; IPR012302; IPR001891; IPR016040; NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1) (Fragment) ME1 Sus scrofa (Pig) TR39603_c2_g2_i2 P28227 MAOX_ANAPL 8.00E-120 GO:0051287; GO:0004473; GO:0016619; GO:0006108; GO:0030145; GO:0005739; GO:0051262 NAD binding; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity; malate dehydrogenase (oxaloacetate-decarboxylating) activity; malate metabolic process; manganese ion binding; mitochondrion; protein tetramerization IPR015884; IPR012301; IPR012302; IPR001891; IPR016040; NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) ME1 Anas platyrhynchos (Domestic duck) (Anas boschas) TR39603_c3_g1_i1 Q96JB1 DYH8_HUMAN 3.00E-65 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 8, axonemal (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8)" DNAH8 Homo sapiens (Human) TR39604_c0_g1_i1 Q54C94 GEFF_DICDI 9.00E-06 GO:0005085; GO:0005622; GO:0051056; GO:0007264 guanyl-nucleotide exchange factor activity; intracellular; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR015915; IPR006594; IPR000651; IPR008937; IPR023578; IPR001895; Ras guanine nucleotide exchange factor F (RasGEF domain-containing protein F) gefF rasGEFF DDB_G0293006 Dictyostelium discoideum (Slime mold) TR39604_c0_g1_i2 Q6TFL4 KLH24_HUMAN 8.00E-30 GO:0030424; GO:0005737; GO:0043204 axon; cytoplasm; perikaryon IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) KLHL24 DRE1 Homo sapiens (Human) TR39605_c0_g1_i3 Q3T0K2 TCPG_BOVIN 0 GO:0005524; GO:0007339; GO:0005832; GO:0005874; GO:0006457; GO:0002199 ATP binding; binding of sperm to zona pellucida; chaperonin-containing T-complex; microtubule; protein folding; zona pellucida receptor complex IPR012719; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) CCT3 Bos taurus (Bovine) TR39606_c1_g2_i2 A7XZ53 XPR1_MUSPA 0 GO:0016021; GO:0005886; GO:0009615; GO:0001618 integral to membrane; plasma membrane; response to virus; virus receptor activity IPR004342; IPR004331; Xenotropic and polytropic retrovirus receptor 1 homolog Xpr1 Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) TR39606_c1_g2_i3 P43585 VTC2_YEAST 2.00E-08 GO:0005783; GO:0000329; GO:0016021; GO:0016237; GO:0006797; GO:0008104; GO:0007034; GO:0033254; GO:0042144 "endoplasmic reticulum; fungal-type vacuole membrane; integral to membrane; microautophagy; polyphosphate metabolic process; protein localization; vacuolar transport; vacuolar transporter chaperone complex; vacuole fusion, non-autophagic" IPR003807; IPR004331; IPR018966; Vacuolar transporter chaperone 2 (Phosphate metabolism protein 1) VTC2 PHM1 YFL004W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39608_c1_g1_i1 Q96GS4 CQ059_HUMAN 1.00E-16 IPR019314; Uncharacterized protein C17orf59 C17orf59 Homo sapiens (Human) TR39610_c5_g1_i1 Q8BH60 GOPC_MOUSE 2.00E-143 GO:0000139; GO:0006914; GO:0030054; GO:0030425; GO:0044325; GO:0005886; GO:0014069; GO:0045211; GO:0043234; GO:0051260; GO:0015031; GO:0005083; GO:0007289; GO:0045202; GO:0019905; GO:0030140 O88597; O95196; Q9EQD0; Q61091; Q61625 Golgi membrane; autophagy; cell junction; dendrite; ion channel binding; plasma membrane; postsynaptic density; postsynaptic membrane; protein complex; protein homooligomerization; protein transport; small GTPase regulator activity; spermatid nucleus differentiation; synapse; syntaxin binding; trans-Golgi network transport vesicle IPR001478; Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) Gopc Mus musculus (Mouse) TR39612_c3_g1_i1 Q96JB1 DYH8_HUMAN 0 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 8, axonemal (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8)" DNAH8 Homo sapiens (Human) TR39613_c1_g1_i2 Q99442 SEC62_HUMAN 2.00E-15 GO:0016235; GO:0006613; GO:0005789; GO:0016021; GO:0045111; GO:0006620; GO:0008565; GO:0004872; GO:0005791 aggresome; cotranslational protein targeting to membrane; endoplasmic reticulum membrane; integral to membrane; intermediate filament cytoskeleton; posttranslational protein targeting to membrane; protein transporter activity; receptor activity; rough endoplasmic reticulum IPR004728; Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1) SEC62 TLOC1 Homo sapiens (Human) TR39613_c1_g3_i2 Q6CLZ9 SEC62_KLULA 5.00E-06 GO:0030176; GO:0008565 integral to endoplasmic reticulum membrane; protein transporter activity IPR004728; IPR011553; Translocation protein SEC62 SEC62 KLLA0E24200g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR39613_c1_g4_i1 Q99442 SEC62_HUMAN 1.00E-20 GO:0016235; GO:0006613; GO:0005789; GO:0016021; GO:0045111; GO:0006620; GO:0008565; GO:0004872; GO:0005791 aggresome; cotranslational protein targeting to membrane; endoplasmic reticulum membrane; integral to membrane; intermediate filament cytoskeleton; posttranslational protein targeting to membrane; protein transporter activity; receptor activity; rough endoplasmic reticulum IPR004728; Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1) SEC62 TLOC1 Homo sapiens (Human) TR39615_c0_g1_i1 Q5ZI03 CIR1_CHICK 3.00E-51 GO:0008380; GO:0000118; GO:0006397; GO:0045892; GO:0016607; GO:0006351 "RNA splicing; histone deacetylase complex; mRNA processing; negative regulation of transcription, DNA-dependent; nuclear speck; transcription, DNA-dependent" IPR019339; Corepressor interacting with RBPJ 1 (CBF1-interacting corepressor) CIR1 CIR RCJMB04_31l21 Gallus gallus (Chicken) TR39616_c2_g1_i1 Q16534 HLF_HUMAN 8.00E-06 GO:0003690; GO:0007275; GO:0005634; GO:0048511; GO:0043565; GO:0003700; GO:0035914; GO:0006366 double-stranded DNA binding; multicellular organismal development; nucleus; rhythmic process; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; skeletal muscle cell differentiation; transcription from RNA polymerase II promoter IPR004827; Hepatic leukemia factor HLF Homo sapiens (Human) TR39616_c2_g1_i2 P53568 CEBPG_MOUSE 3.00E-23 GO:0030183; GO:0006338; GO:0003690; GO:0043353; GO:0001889; GO:0016071; GO:0042267; GO:0043433; GO:0006337; GO:0005634; GO:0045739; GO:0045078; GO:0046982; GO:0042803; GO:0006357; GO:0043565; GO:0008134; GO:0006351 "B cell differentiation; chromatin remodeling; double-stranded DNA binding; enucleate erythrocyte differentiation; liver development; mRNA metabolic process; natural killer cell mediated cytotoxicity; negative regulation of sequence-specific DNA binding transcription factor activity; nucleosome disassembly; nucleus; positive regulation of DNA repair; positive regulation of interferon-gamma biosynthetic process; protein heterodimerization activity; protein homodimerization activity; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding; transcription, DNA-dependent" IPR004827; CCAAT/enhancer-binding protein gamma (C/EBP gamma) (Granulocyte colony-stimulating factor promoter element 1-binding protein) (GPE1-BP) (GPE1-binding protein) (Immunoglobulin enhancer-binding protein 1) (IG/EBP-1) Cebpg Mus musculus (Mouse) TR39616_c2_g1_i3 Q02637 CEBP_DROME 1.00E-06 GO:0000977; GO:0007298; GO:0001708; GO:0005634; GO:0046427; GO:0045944; GO:0046982; GO:0003700; GO:0006351 "RNA polymerase II regulatory region sequence-specific DNA binding; border follicle cell migration; cell fate specification; nucleus; positive regulation of JAK-STAT cascade; positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; CCAAT/enhancer-binding protein (C/EBP) (Slow border cell protein) slbo CG4354 Drosophila melanogaster (Fruit fly) TR39616_c2_g1_i4 P53568 CEBPG_MOUSE 3.00E-23 GO:0030183; GO:0006338; GO:0003690; GO:0043353; GO:0001889; GO:0016071; GO:0042267; GO:0043433; GO:0006337; GO:0005634; GO:0045739; GO:0045078; GO:0046982; GO:0042803; GO:0006357; GO:0043565; GO:0008134; GO:0006351 "B cell differentiation; chromatin remodeling; double-stranded DNA binding; enucleate erythrocyte differentiation; liver development; mRNA metabolic process; natural killer cell mediated cytotoxicity; negative regulation of sequence-specific DNA binding transcription factor activity; nucleosome disassembly; nucleus; positive regulation of DNA repair; positive regulation of interferon-gamma biosynthetic process; protein heterodimerization activity; protein homodimerization activity; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding; transcription, DNA-dependent" IPR004827; CCAAT/enhancer-binding protein gamma (C/EBP gamma) (Granulocyte colony-stimulating factor promoter element 1-binding protein) (GPE1-BP) (GPE1-binding protein) (Immunoglobulin enhancer-binding protein 1) (IG/EBP-1) Cebpg Mus musculus (Mouse) TR39616_c2_g1_i5 Q3T0B9 CEBPG_BOVIN 6.00E-22 GO:0030183; GO:0043353; GO:0016071; GO:0042267; GO:0043433; GO:0005634; GO:0045739; GO:0045078; GO:0043565; GO:0003700; GO:0006351 "B cell differentiation; enucleate erythrocyte differentiation; mRNA metabolic process; natural killer cell mediated cytotoxicity; negative regulation of sequence-specific DNA binding transcription factor activity; nucleus; positive regulation of DNA repair; positive regulation of interferon-gamma biosynthetic process; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; CCAAT/enhancer-binding protein gamma (C/EBP gamma) CEBPG Bos taurus (Bovine) TR39620_c3_g1_i1 Q60803 TRAF3_MOUSE 1.00E-50 GO:0035631; GO:0008063; GO:0006915; GO:0005768; GO:0045087; GO:0009898; GO:0032088; GO:0042981; GO:0050688; GO:0032648; GO:0030162; GO:0002224; GO:0033209; GO:0004842; GO:0008270 Q8VCF0; O35305; P47741; P39429 CD40 receptor complex; Toll signaling pathway; apoptotic process; endosome; innate immune response; internal side of plasma membrane; negative regulation of NF-kappaB transcription factor activity; regulation of apoptotic process; regulation of defense response to virus; regulation of interferon-beta production; regulation of proteolysis; toll-like receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR013323; IPR012227; IPR008974; IPR027128; IPR001841; IPR013083; IPR017907; IPR001293; TNF receptor-associated factor 3 (EC 6.3.2.-) (CD40 receptor-associated factor 1) (CRAF1) (TRAFAMN) Traf3 Craf1 Trafamn Mus musculus (Mouse) TR39620_c3_g2_i3 Q60803 TRAF3_MOUSE 6.00E-26 GO:0035631; GO:0008063; GO:0006915; GO:0005768; GO:0045087; GO:0009898; GO:0032088; GO:0042981; GO:0050688; GO:0032648; GO:0030162; GO:0002224; GO:0033209; GO:0004842; GO:0008270 Q8VCF0; O35305; P47741; P39429 CD40 receptor complex; Toll signaling pathway; apoptotic process; endosome; innate immune response; internal side of plasma membrane; negative regulation of NF-kappaB transcription factor activity; regulation of apoptotic process; regulation of defense response to virus; regulation of interferon-beta production; regulation of proteolysis; toll-like receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR013323; IPR012227; IPR008974; IPR027128; IPR001841; IPR013083; IPR017907; IPR001293; TNF receptor-associated factor 3 (EC 6.3.2.-) (CD40 receptor-associated factor 1) (CRAF1) (TRAFAMN) Traf3 Craf1 Trafamn Mus musculus (Mouse) TR39621_c0_g2_i1 Q3UES3 TNKS2_MOUSE 4.00E-08 GO:0000139; GO:0003950; GO:0016055; GO:0000781; GO:0046872; GO:0035264; GO:0005635; GO:0000242; GO:0048471; GO:0090263; GO:0070213; GO:0070198; GO:0000209; GO:0040014; GO:0000723 "Golgi membrane; NAD+ ADP-ribosyltransferase activity; Wnt receptor signaling pathway; chromosome, telomeric region; metal ion binding; multicellular organism growth; nuclear envelope; pericentriolar material; perinuclear region of cytoplasm; positive regulation of canonical Wnt receptor signaling pathway; protein auto-ADP-ribosylation; protein localization to chromosome, telomeric region; protein polyubiquitination; regulation of multicellular organism growth; telomere maintenance" IPR002110; IPR020683; IPR012317; IPR001660; IPR013761; IPR011510; Tankyrase-2 (TANK2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) Tnks2 Tank2 Mus musculus (Mouse) TR39621_c0_g2_i2 Q460N5 PAR14_HUMAN 4.00E-30 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR39621_c0_g2_i3 Q53GL7 PAR10_HUMAN 1.00E-21 GO:0005794; GO:0003950; GO:0048147; GO:0005634; GO:0070212; GO:0010847 Q9Y530 Golgi apparatus; NAD+ ADP-ribosyltransferase activity; negative regulation of fibroblast proliferation; nucleus; protein poly-ADP-ribosylation; regulation of chromatin assembly IPR012317; IPR003903; Poly [ADP-ribose] polymerase 10 (PARP-10) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) PARP10 Homo sapiens (Human) TR39621_c0_g2_i5 Q3UES3 TNKS2_MOUSE 4.00E-08 GO:0000139; GO:0003950; GO:0016055; GO:0000781; GO:0046872; GO:0035264; GO:0005635; GO:0000242; GO:0048471; GO:0090263; GO:0070213; GO:0070198; GO:0000209; GO:0040014; GO:0000723 "Golgi membrane; NAD+ ADP-ribosyltransferase activity; Wnt receptor signaling pathway; chromosome, telomeric region; metal ion binding; multicellular organism growth; nuclear envelope; pericentriolar material; perinuclear region of cytoplasm; positive regulation of canonical Wnt receptor signaling pathway; protein auto-ADP-ribosylation; protein localization to chromosome, telomeric region; protein polyubiquitination; regulation of multicellular organism growth; telomere maintenance" IPR002110; IPR020683; IPR012317; IPR001660; IPR013761; IPR011510; Tankyrase-2 (TANK2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) Tnks2 Tank2 Mus musculus (Mouse) TR39621_c0_g2_i6 Q8C1B2 PARPT_MOUSE 2.00E-15 GO:0003950; GO:0008209; GO:0008210; GO:0060325; GO:0008585; GO:0030097; GO:0001822; GO:0046872; GO:0044236; GO:0006807; GO:0060021; GO:0048008; GO:0009791; GO:0006471; GO:0048705; GO:0048745; GO:0001570 NAD+ ADP-ribosyltransferase activity; androgen metabolic process; estrogen metabolic process; face morphogenesis; female gonad development; hemopoiesis; kidney development; metal ion binding; multicellular organismal metabolic process; nitrogen compound metabolic process; palate development; platelet-derived growth factor receptor signaling pathway; post-embryonic development; protein ADP-ribosylation; skeletal system morphogenesis; smooth muscle tissue development; vasculogenesis IPR012317; IPR004170; IPR000571; TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) Tiparp Mus musculus (Mouse) TR39621_c0_g2_i7 Q53GL7 PAR10_HUMAN 3.00E-23 GO:0005794; GO:0003950; GO:0048147; GO:0005634; GO:0070212; GO:0010847 Q9Y530 Golgi apparatus; NAD+ ADP-ribosyltransferase activity; negative regulation of fibroblast proliferation; nucleus; protein poly-ADP-ribosylation; regulation of chromatin assembly IPR012317; IPR003903; Poly [ADP-ribose] polymerase 10 (PARP-10) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) PARP10 Homo sapiens (Human) TR39621_c0_g2_i8 Q460N5 PAR14_HUMAN 5.00E-30 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR39621_c0_g2_i9 Q460N5 PAR14_HUMAN 1.00E-30 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR39622_c5_g2_i2 Q9JLC8 SACS_MOUSE 3.00E-41 GO:0005524; GO:0050750; GO:0005739; GO:0090084; GO:0005634 ATP binding; low-density lipoprotein particle receptor binding; mitochondrion; negative regulation of inclusion body assembly; nucleus IPR001623; IPR003594; IPR007842; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) TR39623_c2_g1_i1 P48300 FUCO_CANFA 2.00E-169 GO:0004560; GO:0006004; GO:0005764 alpha-L-fucosidase activity; fucose metabolic process; lysosome IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) FUCA1 Canis familiaris (Dog) (Canis lupus familiaris) TR39623_c2_g1_i2 Q6AYS4 FUCO2_RAT 1.00E-157 GO:0004560; GO:0005975; GO:0005576; GO:0042806; GO:0006004; GO:0005764 alpha-L-fucosidase activity; carbohydrate metabolic process; extracellular region; fucose binding; fucose metabolic process; lysosome IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2) Fuca2 Rattus norvegicus (Rat) TR39623_c2_g1_i4 C3YWU0 FUCO_BRAFL 0 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR39623_c2_g3_i2 C3YWU0 FUCO_BRAFL 2.00E-101 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR39623_c2_g3_i3 Q9VTJ4 FUCO_DROME 6.00E-75 GO:0004560; GO:0042742; GO:0042806; GO:0006004; GO:0006027; GO:0005764 alpha-L-fucosidase activity; defense response to bacterium; fucose binding; fucose metabolic process; glycosaminoglycan catabolic process; lysosome IPR000933; IPR016286; IPR013781; IPR017853; Putative alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) Fuca CG6128 Drosophila melanogaster (Fruit fly) TR39624_c0_g2_i10 Q16932 STX_APLCA 4.00E-131 GO:0016021; GO:0006886; GO:0006836; GO:0016192 integral to membrane; intracellular protein transport; neurotransmitter transport; vesicle-mediated transport IPR015708; IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin Aplysia californica (California sea hare) TR39624_c0_g2_i2 Q16932 STX_APLCA 5.00E-133 GO:0016021; GO:0006886; GO:0006836; GO:0016192 integral to membrane; intracellular protein transport; neurotransmitter transport; vesicle-mediated transport IPR015708; IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin Aplysia californica (California sea hare) TR39624_c0_g2_i3 Q9ZQZ8 SY123_ARATH 2.00E-14 GO:0016021; GO:0006886; GO:0016192 integral to membrane; intracellular protein transport; vesicle-mediated transport IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin-123 (AtSYP123) SYP123 At4g03330 F4C21.26 Arabidopsis thaliana (Mouse-ear cress) TR39624_c0_g2_i7 P50279 STX2_RAT 7.00E-95 GO:0000149; GO:0031201; GO:0000920; GO:0048546; GO:0030855; GO:0016021; GO:0006886; GO:0046907; GO:0030033; GO:0030496; GO:0045026; GO:0030133; GO:0006906; GO:0006903 SNARE binding; SNARE complex; cytokinetic cell separation; digestive tract morphogenesis; epithelial cell differentiation; integral to membrane; intracellular protein transport; intracellular transport; microvillus assembly; midbody; plasma membrane fusion; transport vesicle; vesicle fusion; vesicle targeting IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin-2 (Epimorphin) Stx2 Epim Rattus norvegicus (Rat) TR39624_c0_g2_i8 Q16932 STX_APLCA 3.00E-129 GO:0016021; GO:0006886; GO:0006836; GO:0016192 integral to membrane; intracellular protein transport; neurotransmitter transport; vesicle-mediated transport IPR015708; IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin Aplysia californica (California sea hare) TR39625_c3_g2_i1 Q54DD7 UNC50_DICDI 3.00E-55 GO:0016021 integral to membrane IPR007881; Protein unc-50 homolog DDB_G0292320 Dictyostelium discoideum (Slime mold) TR39625_c3_g2_i2 Q9CQ61 UNC50_MOUSE 4.00E-102 GO:0005794; GO:0000139; GO:0003723; GO:0007166; GO:0016021; GO:0005637; GO:0015031 Golgi apparatus; Golgi membrane; RNA binding; cell surface receptor signaling pathway; integral to membrane; nuclear inner membrane; protein transport IPR007881; Protein unc-50 homolog (Periodontal ligament-specific protein 22) (PDLs22) Unc50 Mus musculus (Mouse) TR39625_c3_g2_i4 Q9CQ61 UNC50_MOUSE 7.00E-103 GO:0005794; GO:0000139; GO:0003723; GO:0007166; GO:0016021; GO:0005637; GO:0015031 Golgi apparatus; Golgi membrane; RNA binding; cell surface receptor signaling pathway; integral to membrane; nuclear inner membrane; protein transport IPR007881; Protein unc-50 homolog (Periodontal ligament-specific protein 22) (PDLs22) Unc50 Mus musculus (Mouse) TR39625_c3_g2_i5 Q5U520 UN50B_XENLA 3.00E-102 GO:0000139; GO:0003723; GO:0016021; GO:0005637; GO:0015031 Golgi membrane; RNA binding; integral to membrane; nuclear inner membrane; protein transport IPR007881; Protein unc-50 homolog B unc50-b Xenopus laevis (African clawed frog) TR39627_c0_g1_i1 Q17R14 MYO1D_BOVIN 0 GO:0005524; GO:0003774; GO:0016459; GO:0010923 ATP binding; motor activity; myosin complex; negative regulation of phosphatase activity IPR000048; IPR001609; IPR010926; IPR027417; Unconventional myosin-Id MYO1D Bos taurus (Bovine) TR39627_c0_g1_i2 Q27966 MYO1C_BOVIN 0 GO:0005524; GO:0009925; GO:0005737; GO:0070062; GO:0031941; GO:0016328; GO:0051028; GO:0045121; GO:0003774; GO:0016459; GO:0005643; GO:0005730; GO:0005654; GO:0038089; GO:0090314; GO:1900748; GO:0006612; GO:2000810; GO:0060171 ATP binding; basal plasma membrane; cytoplasm; extracellular vesicular exosome; filamentous actin; lateral plasma membrane; mRNA transport; membrane raft; motor activity; myosin complex; nuclear pore; nucleolus; nucleoplasm; positive regulation of cell migration by vascular endothelial growth factor signaling pathway; positive regulation of protein targeting to membrane; positive regulation of vascular endothelial growth factor signaling pathway; protein targeting to membrane; regulation of tight junction assembly; stereocilium membrane IPR000048; IPR001609; IPR010926; IPR027417; Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) MYO1C Bos taurus (Bovine) TR39627_c0_g1_i4 Q17R14 MYO1D_BOVIN 0 GO:0005524; GO:0003774; GO:0016459; GO:0010923 ATP binding; motor activity; myosin complex; negative regulation of phosphatase activity IPR000048; IPR001609; IPR010926; IPR027417; Unconventional myosin-Id MYO1D Bos taurus (Bovine) TR39628_c0_g1_i3 P28606 Y1628_SYNP2 1.00E-82 GO:0016787 hydrolase activity IPR000286; IPR023801; Uncharacterized protein SYNPCC7002_A1628 SYNPCC7002_A1628 Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) TR39628_c0_g1_i4 P28606 Y1628_SYNP2 4.00E-83 GO:0016787 hydrolase activity IPR000286; IPR023801; Uncharacterized protein SYNPCC7002_A1628 SYNPCC7002_A1628 Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) TR39630_c0_g1_i3 Q921H8 THIKA_MOUSE 3.00E-175 GO:0003985; GO:0006631; GO:0005739; GO:0005777 acetyl-CoA C-acetyltransferase activity; fatty acid metabolic process; mitochondrion; peroxisome IPR002155; IPR016039; IPR016038; IPR020615; IPR020610; IPR020617; IPR020613; IPR020616; Lipid metabolism; fatty acid metabolism. "3-ketoacyl-CoA thiolase A, peroxisomal (EC 2.3.1.16) (Acetyl-CoA acyltransferase A) (Beta-ketothiolase A) (Peroxisomal 3-oxoacyl-CoA thiolase A)" Acaa1a Acaa1 Mus musculus (Mouse) TR39632_c4_g1_i2 Q5BL38 CEGT_XENTR 3.00E-108 GO:0005794; GO:0000139; GO:0008120; GO:0046479; GO:0016021; GO:0007275 Golgi apparatus; Golgi membrane; ceramide glucosyltransferase activity; glycosphingolipid catabolic process; integral to membrane; multicellular organismal development IPR025993; Lipid metabolism; sphingolipid metabolism. Ceramide glucosyltransferase (EC 2.4.1.80) (UDP-glucose ceramide glucosyltransferase) ugcg TEgg030g03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39633_c2_g3_i4 Q791B0 UBL5_PSAOB 1.00E-37 GO:0005737 cytoplasm IPR000626; Ubiquitin-like protein 5 (Beacon protein) UBL5 Psammomys obesus (Fat sand rat) TR39633_c2_g3_i7 Q791B0 UBL5_PSAOB 7.00E-37 GO:0005737 cytoplasm IPR000626; Ubiquitin-like protein 5 (Beacon protein) UBL5 Psammomys obesus (Fat sand rat) TR39636_c0_g1_i1 Q3ZBT5 STX7_BOVIN 1.00E-41 GO:0005484; GO:0000149; GO:0031201; GO:0031901; GO:0016021; GO:0006886; GO:0016079 SNAP receptor activity; SNARE binding; SNARE complex; early endosome membrane; integral to membrane; intracellular protein transport; synaptic vesicle exocytosis IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin-7 STX7 Bos taurus (Bovine) TR39636_c0_g1_i4 Q9ZQZ8 SY123_ARATH 3.00E-09 GO:0016021; GO:0006886; GO:0016192 integral to membrane; intracellular protein transport; vesicle-mediated transport IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin-123 (AtSYP123) SYP123 At4g03330 F4C21.26 Arabidopsis thaliana (Mouse-ear cress) TR39636_c0_g1_i5 Q3ZBT5 STX7_BOVIN 1.00E-41 GO:0005484; GO:0000149; GO:0031201; GO:0031901; GO:0016021; GO:0006886; GO:0016079 SNAP receptor activity; SNARE binding; SNARE complex; early endosome membrane; integral to membrane; intracellular protein transport; synaptic vesicle exocytosis IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin-7 STX7 Bos taurus (Bovine) TR39637_c2_g1_i1 P15498 VAV_HUMAN 3.00E-08 GO:0038095; GO:0038096; GO:0030676; GO:0042110; GO:0031295; GO:0097190; GO:0005829; GO:0007173; GO:0008543; GO:0005085; GO:0045087; GO:0007229; GO:0046872; GO:0048011; GO:0048015; GO:0005543; GO:0005886; GO:0030168; GO:0043065; GO:0045785; GO:0043087; GO:0035023; GO:0051056; GO:0003700; GO:0007264 Q8IZP0; P00519; P62993; Q07666; Q13094; P08487; P63000; P78314; Q8N720 Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; Rac guanyl-nucleotide exchange factor activity; T cell activation; T cell costimulation; apoptotic signaling pathway; cytosol; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; guanyl-nucleotide exchange factor activity; innate immune response; integrin-mediated signaling pathway; metal ion binding; neurotrophin TRK receptor signaling pathway; phosphatidylinositol-mediated signaling; phospholipid binding; plasma membrane; platelet activation; positive regulation of apoptotic process; positive regulation of cell adhesion; regulation of GTPase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; sequence-specific DNA binding transcription factor activity; small GTPase mediated signal transduction IPR001715; IPR000219; IPR001331; IPR011993; IPR001849; IPR002219; IPR000980; IPR001452; IPR003096; Proto-oncogene vav VAV1 VAV Homo sapiens (Human) TR39637_c2_g2_i1 Q6WKZ7 NOSTN_MOUSE 9.00E-10 GO:0003677; GO:0016023; GO:0006897; GO:0045892; GO:0005634; GO:0005886 P98078 "DNA binding; cytoplasmic membrane-bounded vesicle; endocytosis; negative regulation of transcription, DNA-dependent; nucleus; plasma membrane" IPR001060; IPR001452; IPR013315; Nostrin (Disabled homolog 2-interacting protein 2) (Dab2-interacting protein 2) (Nitric oxide synthase trafficker) (eNOS-trafficking inducer) Nostrin Daip2 Mus musculus (Mouse) TR39637_c6_g2_i2 Q9Z0R6 ITSN2_MOUSE 2.00E-06 GO:0005089; GO:0005509; GO:0005737; GO:0006897; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; calcium ion binding; cytoplasm; endocytosis; phospholipid binding; regulation of Rho protein signal transduction IPR000008; IPR000219; IPR011992; IPR018247; IPR002048; IPR000261; IPR027029; IPR000108; IPR011993; IPR001849; IPR011511; IPR001452; Intersectin-2 (EH domain and SH3 domain regulator of endocytosis 2) (EH and SH3 domains protein 2) (SH3 domain-containing protein 1B) Itsn2 Ese2 Sh3d1B Mus musculus (Mouse) TR39637_c6_g2_i3 Q96B97 SH3K1_HUMAN 5.00E-11 GO:0006915; GO:0016477; GO:0007267; GO:0030659; GO:0005856; GO:0007010; GO:0005829; GO:0006897; GO:0007173; GO:0005925; GO:0042059; GO:0043005; GO:0005886; GO:0008360; GO:0045202 Q8WWN8; Q9ULH1; P52907; P22681; Q13191; P06729; P98078; O94850; P50570; P39052; Q9JKY5; Q92835; Q9Y6R4; P78314; Q99962; O43597; Q13501; Q9ULZ2; O15056; P0CG48 apoptotic process; cell migration; cell-cell signaling; cytoplasmic vesicle membrane; cytoskeleton; cytoskeleton organization; cytosol; endocytosis; epidermal growth factor receptor signaling pathway; focal adhesion; negative regulation of epidermal growth factor receptor signaling pathway; neuron projection; plasma membrane; regulation of cell shape; synapse IPR000108; IPR001452; SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) SH3KBP1 CIN85 Homo sapiens (Human) TR39637_c6_g2_i4 O55043 ARHG7_RAT 3.00E-06 GO:0005089; GO:0043615; GO:0005938; GO:0005737; GO:0005925; GO:0030426; GO:0005085; GO:0030027; GO:0030032; GO:0005543; GO:0043065; GO:0035023; GO:0001726; GO:0007264 P41227; Q13177 Rho guanyl-nucleotide exchange factor activity; astrocyte cell migration; cell cortex; cytoplasm; focal adhesion; growth cone; guanyl-nucleotide exchange factor activity; lamellipodium; lamellipodium assembly; phospholipid binding; positive regulation of apoptotic process; regulation of Rho protein signal transduction; ruffle; small GTPase mediated signal transduction IPR000219; IPR001331; IPR011993; IPR001849; IPR011511; IPR001452; Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) Arhgef7 Pak3bp Pixb Rattus norvegicus (Rat) TR39638_c0_g1_i1 Q5PQT2 MTMR3_RAT 1.00E-53 GO:0005737; GO:0016020; GO:0046872; GO:0046856; GO:0004438; GO:0004722; GO:0004725 cytoplasm; membrane; metal ion binding; phosphatidylinositol dephosphorylation; phosphatidylinositol-3-phosphatase activity; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity IPR010569; IPR017906; IPR016130; IPR000306; IPR017455; IPR011011; IPR013083; Myotubularin-related protein 3 (EC 3.1.3.48) Mtmr3 Rattus norvegicus (Rat) TR39638_c0_g1_i3 Q9TZD0 LST2_CAEEL 7.00E-14 GO:0046872; GO:0032266 metal ion binding; phosphatidylinositol-3-phosphate binding IPR000306; IPR017455; IPR011011; IPR013083; Lateral signaling target protein 2 lst-2 R160.7 Caenorhabditis elegans TR39638_c1_g1_i1 Q5PQT2 MTMR3_RAT 4.00E-160 GO:0005737; GO:0016020; GO:0046872; GO:0046856; GO:0004438; GO:0004722; GO:0004725 cytoplasm; membrane; metal ion binding; phosphatidylinositol dephosphorylation; phosphatidylinositol-3-phosphatase activity; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity IPR010569; IPR017906; IPR016130; IPR000306; IPR017455; IPR011011; IPR013083; Myotubularin-related protein 3 (EC 3.1.3.48) Mtmr3 Rattus norvegicus (Rat) TR39640_c7_g2_i2 Q924H0 NPFF2_MOUSE 3.00E-25 GO:0015629; GO:0005887; GO:0008188; GO:0007218; GO:0043408; GO:0045761; GO:2000479 actin cytoskeleton; integral to plasma membrane; neuropeptide receptor activity; neuropeptide signaling pathway; regulation of MAPK cascade; regulation of adenylate cyclase activity; regulation of cAMP-dependent protein kinase activity IPR000276; IPR017452; IPR005395; IPR005397; Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide NPFF receptor) Npffr2 Gpr74 Npff2 Mus musculus (Mouse) TR39641_c2_g1_i1 P70419 GALT3_MOUSE 2.00E-134 GO:0032580; GO:0005509; GO:0016021; GO:0030145; GO:0048471; GO:0004653; GO:0018242; GO:0018243 Golgi cisterna membrane; calcium ion binding; integral to membrane; manganese ion binding; perinuclear region of cytoplasm; polypeptide N-acetylgalactosaminyltransferase activity; protein O-linked glycosylation via serine; protein O-linked glycosylation via threonine IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 3 (EC 2.4.1.41) (Polypeptide GalNAc transferase 3) (GalNAc-T3) (pp-GaNTase 3) (Protein-UDP acetylgalactosaminyltransferase 3) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3) Galnt3 Mus musculus (Mouse) TR39641_c2_g1_i2 Q95ZJ1 GALT5_CAEEL 0 GO:0000139; GO:0016021; GO:0004653; GO:0018243 Golgi membrane; integral to membrane; polypeptide N-acetylgalactosaminyltransferase activity; protein O-linked glycosylation via threonine IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 5 (pp-GaNTase 5) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5) gly-5 Y39E4B.12 Caenorhabditis elegans TR39641_c2_g1_i4 Q95ZJ1 GALT5_CAEEL 0 GO:0000139; GO:0016021; GO:0004653; GO:0018243 Golgi membrane; integral to membrane; polypeptide N-acetylgalactosaminyltransferase activity; protein O-linked glycosylation via threonine IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 5 (pp-GaNTase 5) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5) gly-5 Y39E4B.12 Caenorhabditis elegans TR39642_c3_g1_i1 P42228 STAT4_MOUSE 2.00E-43 GO:0005509; GO:0008283; GO:0019221; GO:0005737; GO:0005634; GO:0045944; GO:0006468; GO:0043565; GO:0003700; GO:0004871; GO:0006351 P42225 "calcium ion binding; cell proliferation; cytokine-mediated signaling pathway; cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter; protein phosphorylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; signal transducer activity; transcription, DNA-dependent" IPR011992; IPR008967; IPR000980; IPR001217; IPR013800; IPR015988; IPR013801; IPR012345; IPR013799; Signal transducer and activator of transcription 4 Stat4 Mus musculus (Mouse) TR39642_c3_g1_i3 P42232 STA5B_MOUSE 2.00E-127 GO:0006103; GO:0060397; GO:0048541; GO:0000979; GO:0033077; GO:0043029; GO:0000255; GO:0005509; GO:0006101; GO:0006600; GO:0046449; GO:0005829; GO:0046543; GO:0046544; GO:0006631; GO:0007565; GO:0006549; GO:0007595; GO:0019915; GO:0001553; GO:0001779; GO:0043066; GO:0045647; GO:0005634; GO:0006107; GO:0045579; GO:0042104; GO:0045588; GO:0050729; GO:0045086; GO:0045931; GO:0040018; GO:0032825; GO:0045954; GO:0032819; GO:0045944; GO:0042448; GO:0038161; GO:0030155; GO:0030856; GO:0019218; GO:0032355; GO:0070672; GO:0070669; GO:0070670; GO:0003700; GO:0004871; GO:0006105; GO:0019530; GO:0006351; GO:0006573 Q96EY1; Q96EY1-1; Q96EY1-2; P19941 "2-oxoglutarate metabolic process; JAK-STAT cascade involved in growth hormone signaling pathway; Peyer's patch development; RNA polymerase II core promoter sequence-specific DNA binding; T cell differentiation in thymus; T cell homeostasis; allantoin metabolic process; calcium ion binding; citrate metabolic process; creatine metabolic process; creatinine metabolic process; cytosol; development of secondary female sexual characteristics; development of secondary male sexual characteristics; fatty acid metabolic process; female pregnancy; isoleucine metabolic process; lactation; lipid storage; luteinization; natural killer cell differentiation; negative regulation of apoptotic process; negative regulation of erythrocyte differentiation; nucleus; oxaloacetate metabolic process; positive regulation of B cell differentiation; positive regulation of activated T cell proliferation; positive regulation of gamma-delta T cell differentiation; positive regulation of inflammatory response; positive regulation of interleukin-2 biosynthetic process; positive regulation of mitotic cell cycle; positive regulation of multicellular organism growth; positive regulation of natural killer cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell proliferation; positive regulation of transcription from RNA polymerase II promoter; progesterone metabolic process; prolactin signaling pathway; regulation of cell adhesion; regulation of epithelial cell differentiation; regulation of steroid metabolic process; response to estradiol stimulus; response to interleukin-15; response to interleukin-2; response to interleukin-4; sequence-specific DNA binding transcription factor activity; signal transducer activity; succinate metabolic process; taurine metabolic process; transcription, DNA-dependent; valine metabolic process" IPR011992; IPR008967; IPR000980; IPR001217; IPR013800; IPR015988; IPR013801; IPR012345; IPR013799; Signal transducer and activator of transcription 5B Stat5b Mus musculus (Mouse) TR39642_c3_g3_i3 P52633 STAT6_MOUSE 9.00E-09 GO:0000979; GO:0002296; GO:0005509; GO:0005737; GO:0035771; GO:0033598; GO:0060443; GO:0000122; GO:0002829; GO:0000790; GO:0048295; GO:0045944; GO:0042127; GO:0003700; GO:0004871; GO:0006351 "RNA polymerase II core promoter sequence-specific DNA binding; T-helper 1 cell lineage commitment; calcium ion binding; cytoplasm; interleukin-4-mediated signaling pathway; mammary gland epithelial cell proliferation; mammary gland morphogenesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of type 2 immune response; nuclear chromatin; positive regulation of isotype switching to IgE isotypes; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; sequence-specific DNA binding transcription factor activity; signal transducer activity; transcription, DNA-dependent" IPR011992; IPR008967; IPR000980; IPR001217; IPR028187; IPR013800; IPR015988; IPR013801; IPR012345; IPR013799; Signal transducer and transcription activator 6 Stat6 Mus musculus (Mouse) TR39642_c3_g3_i4 P42229 STA5A_HUMAN 3.00E-11 GO:0006103; GO:0060397; GO:0048541; GO:0000979; GO:0033077; GO:0043029; GO:0000255; GO:0005509; GO:0006101; GO:0006600; GO:0046449; GO:0005829; GO:0046543; GO:0046544; GO:0060742; GO:0006631; GO:0007565; GO:0006549; GO:0007595; GO:0019915; GO:0001553; GO:0061180; GO:0001779; GO:0045647; GO:0033026; GO:0005654; GO:0006107; GO:0018108; GO:0045579; GO:0042104; GO:0045588; GO:0050729; GO:0045086; GO:0060376; GO:0070668; GO:0045931; GO:0040018; GO:0032825; GO:0045954; GO:0045944; GO:0038161; GO:0060740; GO:0030155; GO:0030856; GO:0040014; GO:0019218; GO:0006357; GO:0003700; GO:0004871; GO:0006105; GO:0019530; GO:0006351; GO:0006573 Q99490-2; P18031 "2-oxoglutarate metabolic process; JAK-STAT cascade involved in growth hormone signaling pathway; Peyer's patch development; RNA polymerase II core promoter sequence-specific DNA binding; T cell differentiation in thymus; T cell homeostasis; allantoin metabolic process; calcium ion binding; citrate metabolic process; creatine metabolic process; creatinine metabolic process; cytosol; development of secondary female sexual characteristics; development of secondary male sexual characteristics; epithelial cell differentiation involved in prostate gland development; fatty acid metabolic process; female pregnancy; isoleucine metabolic process; lactation; lipid storage; luteinization; mammary gland epithelium development; natural killer cell differentiation; negative regulation of erythrocyte differentiation; negative regulation of mast cell apoptotic process; nucleoplasm; oxaloacetate metabolic process; peptidyl-tyrosine phosphorylation; positive regulation of B cell differentiation; positive regulation of activated T cell proliferation; positive regulation of gamma-delta T cell differentiation; positive regulation of inflammatory response; positive regulation of interleukin-2 biosynthetic process; positive regulation of mast cell differentiation; positive regulation of mast cell proliferation; positive regulation of mitotic cell cycle; positive regulation of multicellular organism growth; positive regulation of natural killer cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of transcription from RNA polymerase II promoter; prolactin signaling pathway; prostate gland epithelium morphogenesis; regulation of cell adhesion; regulation of epithelial cell differentiation; regulation of multicellular organism growth; regulation of steroid metabolic process; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; signal transducer activity; succinate metabolic process; taurine metabolic process; transcription, DNA-dependent; valine metabolic process" IPR011992; IPR008967; IPR000980; IPR001217; IPR013800; IPR015988; IPR013801; IPR012345; IPR013799; Signal transducer and activator of transcription 5A STAT5A STAT5 Homo sapiens (Human) TR39643_c1_g5_i2 Q0VE29 SAM12_MOUSE 2.00E-14 IPR001660; IPR013761; IPR011510; Sterile alpha motif domain-containing protein 12 (SAM domain-containing protein 12) Samd12 Mus musculus (Mouse) TR39646_c0_g1_i1 Q5R9F4 RND3_PONAB 5.00E-50 GO:0005525; GO:0005622; GO:0005886; GO:0007264 GTP binding; intracellular; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Rho-related GTP-binding protein RhoE (Rho family GTPase 3) (Rnd3) RND3 RHOE Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39647_c0_g1_i2 Q08DJ7 AAR2_BOVIN 8.00E-127 IPR007946; Protein AAR2 homolog (AAR2 splicing factor homolog) AAR2 Bos taurus (Bovine) TR39647_c0_g1_i4 Q9Y312 AAR2_HUMAN 4.00E-128 IPR007946; Protein AAR2 homolog (AAR2 splicing factor homolog) AAR2 C20orf4 CGI-23 PRO0225 Homo sapiens (Human) TR39650_c0_g1_i2 O76075 DFFB_HUMAN 2.00E-62 GO:0003677; GO:0006309; GO:0030263; GO:0005829; GO:0004536; GO:0035556; GO:0004516; GO:0000790; GO:0005654 DNA binding; apoptotic DNA fragmentation; apoptotic chromosome condensation; cytosol; deoxyribonuclease activity; intracellular signal transduction; nicotinate phosphoribosyltransferase activity; nuclear chromatin; nucleoplasm IPR015311; IPR003508; DNA fragmentation factor subunit beta (EC 3.-.-.-) (Caspase-activated deoxyribonuclease) (CAD) (Caspase-activated DNase) (Caspase-activated nuclease) (CPAN) (DNA fragmentation factor 40 kDa subunit) (DFF-40) DFFB CAD DFF2 DFF40 Homo sapiens (Human) TR39650_c0_g1_i3 O60543 CIDEA_HUMAN 1.00E-11 GO:0006309; GO:0006629; GO:0005811; GO:0019915; GO:0005740; GO:0043066; GO:0050710; GO:1900118; GO:0050995; GO:0030512; GO:0032720; GO:0005634; GO:0010890; GO:0042803; GO:0006355; GO:0035634; GO:0001659; GO:0006351 "apoptotic DNA fragmentation; lipid metabolic process; lipid particle; lipid storage; mitochondrial envelope; negative regulation of apoptotic process; negative regulation of cytokine secretion; negative regulation of execution phase of apoptosis; negative regulation of lipid catabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of tumor necrosis factor production; nucleus; positive regulation of sequestering of triglyceride; protein homodimerization activity; regulation of transcription, DNA-dependent; response to stilbenoid; temperature homeostasis; transcription, DNA-dependent" IPR003508; Cell death activator CIDE-A (Cell death-inducing DFFA-like effector A) CIDEA Homo sapiens (Human) TR39650_c0_g1_i5 O76075 DFFB_HUMAN 7.00E-64 GO:0003677; GO:0006309; GO:0030263; GO:0005829; GO:0004536; GO:0035556; GO:0004516; GO:0000790; GO:0005654 DNA binding; apoptotic DNA fragmentation; apoptotic chromosome condensation; cytosol; deoxyribonuclease activity; intracellular signal transduction; nicotinate phosphoribosyltransferase activity; nuclear chromatin; nucleoplasm IPR015311; IPR003508; DNA fragmentation factor subunit beta (EC 3.-.-.-) (Caspase-activated deoxyribonuclease) (CAD) (Caspase-activated DNase) (Caspase-activated nuclease) (CPAN) (DNA fragmentation factor 40 kDa subunit) (DFF-40) DFFB CAD DFF2 DFF40 Homo sapiens (Human) TR39652_c1_g1_i1 Q8BGC3 MOT12_MOUSE 5.00E-42 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) Slc16a12 Mct12 Mus musculus (Mouse) TR39652_c1_g1_i4 Q8BGC3 MOT12_MOUSE 4.00E-42 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) Slc16a12 Mct12 Mus musculus (Mouse) TR39656_c0_g1_i1 P30975 TLR2_DROME 7.00E-30 GO:0005887; GO:0004995 integral to plasma membrane; tachykinin receptor activity IPR000276; IPR017452; IPR001681; Tachykinin-like peptides receptor 99D (dTKR) Takr99D CG7887 Drosophila melanogaster (Fruit fly) TR39656_c0_g1_i3 P21452 NK2R_HUMAN 1.00E-39 GO:0007588; GO:0005887; GO:0014827; GO:0006936; GO:0033685; GO:0035106; GO:0014057; GO:0070474; GO:0043117; GO:0070459; GO:0006950; GO:0016497; GO:0004995 P20366 "excretion; integral to plasma membrane; intestine smooth muscle contraction; muscle contraction; negative regulation of luteinizing hormone secretion; operant conditioning; positive regulation of acetylcholine secretion, neurotransmission; positive regulation of uterine smooth muscle contraction; positive regulation of vascular permeability; prolactin secretion; response to stress; substance K receptor activity; tachykinin receptor activity" IPR000276; IPR017452; IPR001681; IPR000913; Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2) TACR2 NK2R NKNAR TAC2R Homo sapiens (Human) TR39656_c0_g1_i5 Q9Y5X5 NPFF2_HUMAN 9.00E-42 GO:0004930; GO:0015629; GO:0009582; GO:0005887; GO:0008188; GO:0007218; GO:0043408; GO:0045761; GO:2000479 G-protein coupled receptor activity; actin cytoskeleton; detection of abiotic stimulus; integral to plasma membrane; neuropeptide receptor activity; neuropeptide signaling pathway; regulation of MAPK cascade; regulation of adenylate cyclase activity; regulation of cAMP-dependent protein kinase activity IPR000276; IPR017452; IPR005395; IPR005397; Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) NPFFR2 GPR74 NPFF2 NPGPR Homo sapiens (Human) TR39656_c0_g1_i6 P30974 TLR1_DROME 4.00E-40 GO:0004950; GO:0070098; GO:0006935; GO:0005887; GO:0004995 chemokine receptor activity; chemokine-mediated signaling pathway; chemotaxis; integral to plasma membrane; tachykinin receptor activity IPR000355; IPR000276; IPR017452; IPR001681; Tachykinin-like peptides receptor 86C (NKD) Takr86C NKD CG6515 Drosophila melanogaster (Fruit fly) TR39656_c0_g1_i7 Q9Y5X5 NPFF2_HUMAN 9.00E-42 GO:0004930; GO:0015629; GO:0009582; GO:0005887; GO:0008188; GO:0007218; GO:0043408; GO:0045761; GO:2000479 G-protein coupled receptor activity; actin cytoskeleton; detection of abiotic stimulus; integral to plasma membrane; neuropeptide receptor activity; neuropeptide signaling pathway; regulation of MAPK cascade; regulation of adenylate cyclase activity; regulation of cAMP-dependent protein kinase activity IPR000276; IPR017452; IPR005395; IPR005397; Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) NPFFR2 GPR74 NPFF2 NPGPR Homo sapiens (Human) TR39657_c0_g1_i1 Q6RWA9 AT1A_TAESO 0 GO:0005524; GO:0006754; GO:0016021; GO:0046872; GO:0005391 ATP binding; ATP biosynthetic process; integral to membrane; metal ion binding; sodium:potassium-exchanging ATPase activity IPR006068; IPR004014; IPR023299; IPR005775; IPR018303; IPR023298; IPR008250; IPR001757; IPR023214; Sodium/potassium-transporting ATPase subunit alpha (Na(+)/K(+) ATPase alpha subunit) (EC 3.6.3.9) (Sodium pump subunit alpha) (TNaK1-alpha) Taenia solium (Pork tapeworm) TR39659_c0_g1_i1 P18292 THRB_RAT 3.00E-43 GO:0006953; GO:0007596; GO:0005509; GO:0071260; GO:0005615; GO:0006508; GO:0004252 acute-phase response; blood coagulation; calcium ion binding; cellular response to mechanical stimulus; extracellular space; proteolysis; serine-type endopeptidase activity IPR017857; IPR000294; IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR003966; IPR018992; IPR009003; Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] F2 Rattus norvegicus (Rat) TR39659_c0_g1_i2 Q62381 TLL1_MOUSE 2.00E-37 GO:0005509; GO:0030154; GO:0005518; GO:0005576; GO:0004222; GO:0007275; GO:0006508; GO:0008270 calcium ion binding; cell differentiation; collagen binding; extracellular region; metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Tolloid-like protein 1 (mTll) (EC 3.4.24.-) Tll1 Tll Mus musculus (Mouse) TR39659_c0_g1_i3 P69526 TMPS9_RAT 6.00E-34 GO:0005887; GO:0006508; GO:0004252 integral to plasma membrane; proteolysis; serine-type endopeptidase activity IPR002172; IPR017324; IPR001254; IPR018114; IPR001314; IPR009003; Transmembrane protease serine 9 (EC 3.4.21.-) (Polyserase-I) (Polyserine protease 1) (Polyserase-1) [Cleaved into: Serase-1; Serase-2; Serase-3] Tmprss9 Rattus norvegicus (Rat) TR39659_c0_g1_i4 Q62381 TLL1_MOUSE 2.00E-37 GO:0005509; GO:0030154; GO:0005518; GO:0005576; GO:0004222; GO:0007275; GO:0006508; GO:0008270 calcium ion binding; cell differentiation; collagen binding; extracellular region; metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Tolloid-like protein 1 (mTll) (EC 3.4.24.-) Tll1 Tll Mus musculus (Mouse) TR39659_c0_g1_i6 P18292 THRB_RAT 7.00E-46 GO:0006953; GO:0007596; GO:0005509; GO:0071260; GO:0005615; GO:0006508; GO:0004252 acute-phase response; blood coagulation; calcium ion binding; cellular response to mechanical stimulus; extracellular space; proteolysis; serine-type endopeptidase activity IPR017857; IPR000294; IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR003966; IPR018992; IPR009003; Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] F2 Rattus norvegicus (Rat) TR39660_c0_g1_i1 Q4VCS5 AMOT_HUMAN 6.00E-52 GO:0030036; GO:0005884; GO:0043532; GO:0043534; GO:0042074; GO:0009986; GO:0007043; GO:0034613; GO:0006935; GO:0005737; GO:0005829; GO:0030139; GO:0003365; GO:0009897; GO:0001702; GO:0035329; GO:0001701; GO:0016021; GO:0030027; GO:0034260; GO:0016525; GO:0043116; GO:0043536; GO:0045793; GO:0040019; GO:0051496; GO:0004872; GO:0030334; GO:0051056; GO:0001726; GO:0001725; GO:0005923; GO:0001570 Q68EM7; P35240 actin cytoskeleton organization; actin filament; angiostatin binding; blood vessel endothelial cell migration; cell migration involved in gastrulation; cell surface; cell-cell junction assembly; cellular protein localization; chemotaxis; cytoplasm; cytosol; endocytic vesicle; establishment of cell polarity involved in ameboidal cell migration; external side of plasma membrane; gastrulation with mouth forming second; hippo signaling cascade; in utero embryonic development; integral to membrane; lamellipodium; negative regulation of GTPase activity; negative regulation of angiogenesis; negative regulation of vascular permeability; positive regulation of blood vessel endothelial cell migration; positive regulation of cell size; positive regulation of embryonic development; positive regulation of stress fiber assembly; receptor activity; regulation of cell migration; regulation of small GTPase mediated signal transduction; ruffle; stress fiber; tight junction; vasculogenesis IPR009114; IPR024646; Angiomotin AMOT KIAA1071 Homo sapiens (Human) TR39660_c0_g1_i3 Q8VHG2 AMOT_MOUSE 6.00E-53 GO:0008180; GO:0030036; GO:0005884; GO:0043532; GO:0043534; GO:0042074; GO:0034613; GO:0006935; GO:0031410; GO:0030139; GO:0003365; GO:0009897; GO:0001702; GO:0035329; GO:0001701; GO:0016021; GO:0030027; GO:0034260; GO:0016525; GO:0043116; GO:0043536; GO:0040019; GO:0004872; GO:0051056; GO:0001726; GO:0001725; GO:0005923; GO:0001570 COP9 signalosome; actin cytoskeleton organization; actin filament; angiostatin binding; blood vessel endothelial cell migration; cell migration involved in gastrulation; cellular protein localization; chemotaxis; cytoplasmic vesicle; endocytic vesicle; establishment of cell polarity involved in ameboidal cell migration; external side of plasma membrane; gastrulation with mouth forming second; hippo signaling cascade; in utero embryonic development; integral to membrane; lamellipodium; negative regulation of GTPase activity; negative regulation of angiogenesis; negative regulation of vascular permeability; positive regulation of blood vessel endothelial cell migration; positive regulation of embryonic development; receptor activity; regulation of small GTPase mediated signal transduction; ruffle; stress fiber; tight junction; vasculogenesis IPR009114; IPR024646; Angiomotin Amot Kiaa1071 Mus musculus (Mouse) TR39661_c0_g2_i1 Q75J93 CPAS1_DICDI 2.00E-59 GO:0030127; GO:0006888; GO:0005525; GO:0003924; GO:0006886; GO:0007264; GO:0008270 COPII vesicle coat; ER to Golgi vesicle-mediated transport; GTP binding; GTPase activity; intracellular protein transport; small GTPase mediated signal transduction; zinc ion binding IPR027417; IPR005225; IPR001806; IPR020849; IPR002035; IPR006895; Circularly permutated Ras protein 1 (DdiCPRas1) cpras1 DDB_G0277381 Dictyostelium discoideum (Slime mold) TR39662_c0_g2_i1 Q54RR5 ACDSB_DICDI 2.00E-06 GO:0003995; GO:0006631; GO:0050660 acyl-CoA dehydrogenase activity; fatty acid metabolic process; flavin adenine dinucleotide binding IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Lipid metabolism; mitochondrial fatty acid beta-oxidation. Probable short/branched chain specific acyl-CoA dehydrogenase (SBCAD) (EC 1.3.8.5) acadsb DDB_G0282967 Dictyostelium discoideum (Slime mold) TR39662_c0_g2_i2 P33224 AIDB_ECOLI 2.00E-20 GO:0005737; GO:0008470; GO:0045892; GO:0006950; GO:0043565 "cytoplasm; isovaleryl-CoA dehydrogenase activity; negative regulation of transcription, DNA-dependent; response to stress; sequence-specific DNA binding" IPR006089; IPR006091; IPR009075; IPR009100; Putative acyl-CoA dehydrogenase AidB (EC 1.3.99.-) aidB b4187 JW5867 Escherichia coli (strain K12) TR39662_c0_g2_i4 Q5EAD4 ACDSB_BOVIN 2.00E-08 GO:0003995; GO:0006631; GO:0050660; GO:0005759 acyl-CoA dehydrogenase activity; fatty acid metabolic process; flavin adenine dinucleotide binding; mitochondrial matrix IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Lipid metabolism; mitochondrial fatty acid beta-oxidation. "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (SBCAD) (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-MEBCAD) (2-methylbutyryl-coenzyme A dehydrogenase) (2-methylbutyryl-CoA dehydrogenase)" ACADSB Bos taurus (Bovine) TR39663_c0_g1_i3 Q6AZB8 HARB1_DANRE 9.00E-19 GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) TR39665_c1_g1_i3 E1BD59 TRI56_BOVIN 3.00E-06 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) TR39666_c1_g1_i1 Q91637 KIF2A_XENLA 2.00E-69 GO:0005524; GO:0051301; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0005815; GO:0007018; GO:0007067; GO:0007052; GO:0000922 ATP binding; cell division; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule organizing center; microtubule-based movement; mitosis; mitotic spindle organization; spindle pole IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF2A (Kinesin-related protein xKIF2) kif2a kif2 Xenopus laevis (African clawed frog) TR39667_c0_g5_i2 Q96RW7 HMCN1_HUMAN 6.00E-11 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR39667_c0_g5_i4 A2VEC9 SSPO_HUMAN 8.00E-06 GO:0007155; GO:0005615; GO:0010466; GO:0030414 cell adhesion; extracellular space; negative regulation of peptidase activity; peptidase inhibitor activity IPR000421; IPR006207; IPR008979; IPR023415; IPR002172; IPR008037; IPR000884; IPR002919; IPR014853; IPR006552; IPR001007; IPR001846; SCO-spondin SSPO KIAA2036 Homo sapiens (Human) TR39668_c0_g1_i2 P29775 ETS4_DROME 2.00E-39 GO:0005634; GO:0043565; GO:0003700 nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR000418; IPR003118; IPR013761; IPR011991; DNA-binding protein D-ETS-4 Ets98B ETS-4 CG5583 Drosophila melanogaster (Fruit fly) TR39668_c0_g1_i3 O95238 SPDEF_HUMAN 2.00E-37 GO:0060576; GO:0060480; GO:0007275; GO:0010454; GO:0000122; GO:0005634; GO:0043065; GO:0010455; GO:0045944; GO:0043565; GO:0003700; GO:0006351 "intestinal epithelial cell development; lung goblet cell differentiation; multicellular organismal development; negative regulation of cell fate commitment; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of apoptotic process; positive regulation of cell fate commitment; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor) SPDEF PDEF PSE Homo sapiens (Human) TR39670_c1_g5_i1 Q92616 GCN1L_HUMAN 0 GO:0006417; GO:0005840; GO:0008135 "regulation of translation; ribosome; translation factor activity, nucleic acid binding" IPR011989; IPR016024; IPR000225; IPR022716; IPR026827; IPR021133; Translational activator GCN1 (HsGCN1) (GCN1-like protein 1) GCN1L1 KIAA0219 Homo sapiens (Human) TR39670_c1_g5_i2 Q92616 GCN1L_HUMAN 0 GO:0006417; GO:0005840; GO:0008135 "regulation of translation; ribosome; translation factor activity, nucleic acid binding" IPR011989; IPR016024; IPR000225; IPR022716; IPR026827; IPR021133; Translational activator GCN1 (HsGCN1) (GCN1-like protein 1) GCN1L1 KIAA0219 Homo sapiens (Human) TR39670_c1_g5_i4 Q92616 GCN1L_HUMAN 0 GO:0006417; GO:0005840; GO:0008135 "regulation of translation; ribosome; translation factor activity, nucleic acid binding" IPR011989; IPR016024; IPR000225; IPR022716; IPR026827; IPR021133; Translational activator GCN1 (HsGCN1) (GCN1-like protein 1) GCN1L1 KIAA0219 Homo sapiens (Human) TR39670_c1_g5_i5 O14134 ELF1_SCHPO 2.00E-25 GO:0005524; GO:0016887; GO:0005829; GO:0005634; GO:0016973; GO:0043234; GO:0042274 ATP binding; ATPase activity; cytosol; nucleus; poly(A)+ mRNA export from nucleus; protein complex; ribosomal small subunit biogenesis IPR003593; IPR003439; IPR017871; IPR011989; IPR016024; IPR023780; IPR000953; IPR015688; IPR027417; mRNA export factor elf1 elf1 SPAC3C7.08c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR39671_c4_g1_i3 Q28BP9 FAF2_XENTR 2.00E-148 GO:0005783; GO:0005811 endoplasmic reticulum; lipid particle IPR012336; IPR006577; IPR009060; IPR001012; FAS-associated factor 2 (UBX domain-containing protein 8) faf2 ubxd8 TNeu075m11.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39672_c4_g1_i1 Q5XJS0 FA73A_DANRE 5.00E-89 GO:0016021 integral to membrane IPR019392; Protein FAM73A fam73a zgc:101625 Danio rerio (Zebrafish) (Brachydanio rerio) TR39672_c4_g1_i2 Q8BK03 FA73B_MOUSE 2.00E-91 GO:0060348; GO:0016021 bone development; integral to membrane IPR019392; Protein FAM73B Fam73b Mus musculus (Mouse) TR39673_c0_g3_i1 P31319 KAPR_APLCA 0 GO:0030552; GO:0005952; GO:0008603 cAMP binding; cAMP-dependent protein kinase complex; cAMP-dependent protein kinase regulator activity IPR002373; IPR012198; IPR003117; IPR018490; IPR018488; IPR000595; IPR014710; cAMP-dependent protein kinase regulatory subunit (N4 subunit of protein kinase A) Aplysia californica (California sea hare) TR39673_c0_g3_i2 P00514 KAP0_BOVIN 3.00E-167 GO:0030552; GO:0005952; GO:0008603; GO:0060038; GO:0001707; GO:0006469; GO:0031594; GO:0005886; GO:0045214 cAMP binding; cAMP-dependent protein kinase complex; cAMP-dependent protein kinase regulator activity; cardiac muscle cell proliferation; mesoderm formation; negative regulation of protein kinase activity; neuromuscular junction; plasma membrane; sarcomere organization IPR002373; IPR012198; IPR003117; IPR018490; IPR018488; IPR000595; IPR014710; "cAMP-dependent protein kinase type I-alpha regulatory subunit [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed]" PRKAR1A Bos taurus (Bovine) TR39674_c1_g2_i2 Q8BX37 PAPL_MOUSE 1.00E-77 GO:0003993; GO:0005576; GO:0046872 acid phosphatase activity; extracellular region; metal ion binding IPR004843; IPR008963; IPR015914; IPR025733; Iron/zinc purple acid phosphatase-like protein (EC 3.1.3.2) Papl Mus musculus (Mouse) TR39675_c0_g4_i7 Q6NWC9 GKAP1_DANRE 3.00E-27 GO:0005794; GO:0007165 Golgi apparatus; signal transduction IPR026109; G kinase-anchoring protein 1 gkap1 zgc:85804 Danio rerio (Zebrafish) (Brachydanio rerio) TR39675_c0_g4_i9 Q6NWC9 GKAP1_DANRE 2.00E-27 GO:0005794; GO:0007165 Golgi apparatus; signal transduction IPR026109; G kinase-anchoring protein 1 gkap1 zgc:85804 Danio rerio (Zebrafish) (Brachydanio rerio) TR39676_c1_g1_i1 Q9W734 SMAD6_CHICK 2.00E-69 GO:0031589; GO:0003682; GO:0006955; GO:0046872; GO:0030514; GO:0010991; GO:0043066; GO:0008285; GO:0060394; GO:0030512; GO:0005634; GO:0034616; GO:0003700; GO:0005667; GO:0044212; GO:0006351; GO:0007179; GO:0030617; GO:0001657; GO:0007352 "cell-substrate adhesion; chromatin binding; immune response; metal ion binding; negative regulation of BMP signaling pathway; negative regulation of SMAD protein complex assembly; negative regulation of apoptotic process; negative regulation of cell proliferation; negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; nucleus; response to laminar fluid shear stress; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription regulatory region DNA binding; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; ureteric bud development; zygotic specification of dorsal/ventral axis" IPR013790; IPR003619; IPR013019; IPR017855; IPR001132; IPR008984; Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) SMAD6 MADH6 Gallus gallus (Chicken) TR39676_c6_g1_i1 P45896 SMA3_CAEEL 2.00E-06 GO:0030509; GO:0003677; GO:0005737; GO:0050832; GO:0045087; GO:0046872; GO:0002119; GO:0005634; GO:0045793; GO:0040018; GO:0046622; GO:0045944; GO:0003700; GO:0045138; GO:0005667; GO:0006351; GO:0007179; GO:0030618 "BMP signaling pathway; DNA binding; cytoplasm; defense response to fungus; innate immune response; metal ion binding; nematode larval development; nucleus; positive regulation of cell size; positive regulation of multicellular organism growth; positive regulation of organ growth; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; tail tip morphogenesis; transcription factor complex; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity" IPR013790; IPR003619; IPR013019; IPR017855; IPR001132; IPR008984; Dwarfin sma-3 (MAD protein homolog 2) sma-3 cem-2 R13F6.9 Caenorhabditis elegans TR39679_c0_g1_i2 Q3V096 ANR42_MOUSE 8.00E-158 GO:0005634; GO:0051092; GO:1900017 nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of cytokine production involved in inflammatory response IPR002110; IPR020683; Ankyrin repeat domain-containing protein 42 Ankrd42 Mus musculus (Mouse) TR39679_c0_g1_i3 Q07DY6 ASZ1_COLGU 2.00E-06 GO:0043046; GO:0030154; GO:0031047; GO:0007140; GO:0007275; GO:0071546; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; cell differentiation; gene silencing by RNA; male meiosis; multicellular organismal development; pi-body; piRNA metabolic process; spermatogenesis IPR002110; IPR020683; IPR001660; IPR013761; IPR011510; "Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)" ASZ1 GASZ Colobus guereza (Mantled guereza) (Eastern black-and-white colobus monkey) TR39679_c0_g1_i4 Q8N9B4 ANR42_HUMAN 3.00E-117 GO:0005634; GO:0051092; GO:1900017 nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of cytokine production involved in inflammatory response IPR002110; IPR020683; IPR018247; Ankyrin repeat domain-containing protein 42 ANKRD42 Homo sapiens (Human) TR39680_c3_g1_i1 P59035 LRRC3_RAT 2.00E-09 GO:0016021 integral to membrane IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing protein 3 Lrrc3 Rattus norvegicus (Rat) TR39680_c3_g3_i1 Q45R42 LRRC4_RAT 2.00E-06 GO:0030054; GO:0016021; GO:0045211 cell junction; integral to membrane; postsynaptic membrane IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; IPR026906; IPR026882; Leucine-rich repeat-containing protein 4 (Netrin-G2 ligand) (NGL-2) Lrrc4 Rattus norvegicus (Rat) TR39680_c3_g5_i1 P59035 LRRC3_RAT 1.00E-09 GO:0016021 integral to membrane IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing protein 3 Lrrc3 Rattus norvegicus (Rat) TR39680_c3_g8_i14 Q9QZ85 IIGP1_MOUSE 3.00E-13 GO:0019003; GO:0005525; GO:0003924; GO:0032580; GO:0035458; GO:0019221; GO:0050829; GO:0042832; GO:0005789; GO:0042802; GO:0045087; GO:0031965; GO:0010506; GO:0020005 GDP binding; GTP binding; GTPase activity; Golgi cisterna membrane; cellular response to interferon-beta; cytokine-mediated signaling pathway; defense response to Gram-negative bacterium; defense response to protozoan; endoplasmic reticulum membrane; identical protein binding; innate immune response; nuclear membrane; regulation of autophagy; symbiont-containing vacuole membrane IPR007743; IPR027417; Interferon-inducible GTPase 1 (EC 3.6.5.-) Iigp1 Irga6 Mus musculus (Mouse) TR39680_c3_g8_i4 Q9QZ85 IIGP1_MOUSE 2.00E-15 GO:0019003; GO:0005525; GO:0003924; GO:0032580; GO:0035458; GO:0019221; GO:0050829; GO:0042832; GO:0005789; GO:0042802; GO:0045087; GO:0031965; GO:0010506; GO:0020005 GDP binding; GTP binding; GTPase activity; Golgi cisterna membrane; cellular response to interferon-beta; cytokine-mediated signaling pathway; defense response to Gram-negative bacterium; defense response to protozoan; endoplasmic reticulum membrane; identical protein binding; innate immune response; nuclear membrane; regulation of autophagy; symbiont-containing vacuole membrane IPR007743; IPR027417; Interferon-inducible GTPase 1 (EC 3.6.5.-) Iigp1 Irga6 Mus musculus (Mouse) TR39680_c3_g8_i7 Q6AYF9 IIGP5_RAT 8.00E-19 GO:0005525; GO:0016817; GO:0016020 "GTP binding; hydrolase activity, acting on acid anhydrides; membrane" IPR007743; IPR027417; Interferon-inducible GTPase 5 (EC 3.6.5.-) (Immunity-related GTPase cinema 1) Irgc Iigp5 Irgc1 Rattus norvegicus (Rat) TR39680_c3_g8_i8 Q32KW9 IIGP5_BOVIN 2.00E-16 GO:0005525; GO:0016817; GO:0016020 "GTP binding; hydrolase activity, acting on acid anhydrides; membrane" IPR007743; IPR027417; Interferon-inducible GTPase 5 (EC 3.6.5.-) (Immunity-related GTPase cinema 1) IRGC IIGP5 IRGC1 Bos taurus (Bovine) TR39680_c3_g8_i9 B3CL86 ENGB_WOLPP 2.00E-06 GO:0005525; GO:0000917 GTP binding; barrier septum assembly IPR019987; IPR006073; IPR027417; Probable GTP-binding protein EngB engB WP0042 Wolbachia pipientis subsp. Culex pipiens (strain wPip) TR39681_c1_g2_i1 Q2KID4 DNAL1_BOVIN 6.00E-82 IPR001611; IPR025875; "Dynein light chain 1, axonemal" DNAL1 Bos taurus (Bovine) TR39681_c1_g2_i3 Q54Q39 PP1R7_DICDI 6.00E-10 GO:0005634 nucleus IPR001611; IPR003603; Protein phosphatase 1 regulatory subunit pprA pprA DDB_G0284039 Dictyostelium discoideum (Slime mold) TR39682_c1_g3_i1 Q6DE96 IWS1A_XENLA 2.00E-70 GO:0003677; GO:0008380; GO:0006397; GO:0051028; GO:0005634; GO:0006355; GO:0006351 "DNA binding; RNA splicing; mRNA processing; mRNA transport; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR017923; Protein IWS1 homolog A (IWS1-like protein A) iws1-a iws1l-a Xenopus laevis (African clawed frog) TR39683_c3_g4_i1 Q8IZJ3 CPMD8_HUMAN 4.00E-15 GO:0005615; GO:0010951; GO:0005886; GO:0004867 extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR002350; IPR001599; IPR019742; IPR019565; IPR022041; IPR008930; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 CPAMD8 KIAA1283 Homo sapiens (Human) TR39685_c2_g1_i1 P41212 ETV6_HUMAN 1.00E-28 GO:0030154; GO:0005634; GO:0043565; GO:0003700; GO:0006351 Q9UKV0-3 "cell differentiation; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) ETV6 TEL TEL1 Homo sapiens (Human) TR39685_c2_g1_i10 Q0VC65 ETV6_BOVIN 2.00E-28 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; Transcription factor ETV6 ETV6 Bos taurus (Bovine) TR39685_c2_g1_i2 Q0VC65 ETV6_BOVIN 2.00E-28 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; Transcription factor ETV6 ETV6 Bos taurus (Bovine) TR39685_c2_g1_i3 Q01842 POK_DROME 4.00E-23 GO:0007254; GO:0007464; GO:0045467; GO:0003705; GO:0007298; GO:0001709; GO:0005737; GO:0048813; GO:0007391; GO:0006897; GO:0008406; GO:0048747; GO:0007517; GO:0046580; GO:0030178; GO:0046533; GO:0000122; GO:0005634; GO:0060233; GO:0045678; GO:0090175; GO:0045610; GO:0043565 JNK cascade; R3/R4 cell fate commitment; R7 cell development; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; border follicle cell migration; cell fate determination; cytoplasm; dendrite morphogenesis; dorsal closure; endocytosis; gonad development; muscle fiber development; muscle organ development; negative regulation of Ras protein signal transduction; negative regulation of Wnt receptor signaling pathway; negative regulation of photoreceptor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; nucleus; oenocyte delamination; positive regulation of R7 cell differentiation; regulation of establishment of planar polarity; regulation of hemocyte differentiation; sequence-specific DNA binding IPR000418; IPR003118; IPR013761; IPR011991; Ets DNA-binding protein pokkuri (Protein anterior open) (Protein yan) aop pok Yan CG3166 Drosophila melanogaster (Fruit fly) TR39685_c2_g1_i4 Q0VC65 ETV6_BOVIN 2.00E-28 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; Transcription factor ETV6 ETV6 Bos taurus (Bovine) TR39685_c2_g1_i6 P41212 ETV6_HUMAN 2.00E-28 GO:0030154; GO:0005634; GO:0043565; GO:0003700; GO:0006351 Q9UKV0-3 "cell differentiation; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) ETV6 TEL TEL1 Homo sapiens (Human) TR39685_c2_g1_i7 P41212 ETV6_HUMAN 2.00E-28 GO:0030154; GO:0005634; GO:0043565; GO:0003700; GO:0006351 Q9UKV0-3 "cell differentiation; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) ETV6 TEL TEL1 Homo sapiens (Human) TR39688_c1_g1_i1 P35858 ALS_HUMAN 2.00E-39 GO:0007155; GO:0044267; GO:0005615; GO:0005520; GO:0005634; GO:0007165 cell adhesion; cellular protein metabolic process; extracellular space; insulin-like growth factor binding; nucleus; signal transduction IPR000483; IPR001611; IPR003591; IPR000372; Insulin-like growth factor-binding protein complex acid labile subunit (ALS) IGFALS ALS Homo sapiens (Human) TR39688_c1_g2_i1 P24014 SLIT_DROME 6.00E-12 GO:0035385; GO:0071666; GO:0016199; GO:0005509; GO:0048813; GO:0007502; GO:0035050; GO:0007427; GO:0008347; GO:0008406; GO:0008201; GO:0050929; GO:0046331; GO:0008078; GO:0001764; GO:0003151; GO:0005886; GO:0022409; GO:0005578; GO:2000274; GO:0007432 "Roundabout signaling pathway; Slit-Robo signaling complex; axon midline choice point recognition; calcium ion binding; dendrite morphogenesis; digestive tract mesoderm development; embryonic heart tube development; epithelial cell migration, open tracheal system; glial cell migration; gonad development; heparin binding; induction of negative chemotaxis; lateral inhibition; mesodermal cell migration; neuron migration; outflow tract morphogenesis; plasma membrane; positive regulation of cell-cell adhesion; proteinaceous extracellular matrix; regulation of epithelial cell migration, open tracheal system; salivary gland boundary specification" IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; IPR026906; Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) TR39689_c0_g2_i1 Q920B9 SP16H_MOUSE 0 GO:0006281; GO:0006260; GO:0005694; GO:0005634; GO:0006355; GO:0006351 "DNA repair; DNA replication; chromosome; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR013719; IPR013953; IPR000994; FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) Supt16h Fact140 Factp140 Supt16 Mus musculus (Mouse) TR39689_c0_g2_i2 Q61E63 SPT16_CAEBR 0 GO:0006281; GO:0006260; GO:0005694; GO:0005634; GO:0006355; GO:0006351 "DNA repair; DNA replication; chromosome; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR013719; IPR013953; IPR000994; FACT complex subunit spt-16 (Facilitates chromatin transcription complex subunit spt-16) spt-16 CBG12204 Caenorhabditis briggsae TR39689_c0_g2_i3 Q920B9 SP16H_MOUSE 0 GO:0006281; GO:0006260; GO:0005694; GO:0005634; GO:0006355; GO:0006351 "DNA repair; DNA replication; chromosome; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR013719; IPR013953; IPR000994; FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) Supt16h Fact140 Factp140 Supt16 Mus musculus (Mouse) TR3969_c0_g1_i1 Q9GV77 FREM2_LYTVA 2.00E-20 GO:0005509; GO:0007154; GO:0007156; GO:0016021; GO:0007275; GO:0005886 calcium ion binding; cell communication; homophilic cell adhesion; integral to membrane; multicellular organismal development; plasma membrane IPR002126; IPR003644; Extracellular matrix protein 3 (FREM2 homolog) ECM3 Lytechinus variegatus (Green sea urchin) (Variegated urchin) TR39690_c0_g1_i1 Q5TD94 RSH4A_HUMAN 2.00E-125 GO:0035085; GO:0035083; GO:0003341; GO:0005856; GO:0005730; GO:0001534 cilium axoneme; cilium axoneme assembly; cilium movement; cytoskeleton; nucleolus; radial spoke IPR006802; Radial spoke head protein 4 homolog A (Radial spoke head-like protein 3) RSPH4A RSHL3 Homo sapiens (Human) TR39692_c0_g1_i1 Q5T4F7 SFRP5_HUMAN 3.00E-55 GO:0030165; GO:0042813; GO:0017147; GO:0009653; GO:0006915; GO:0007420; GO:0030154; GO:0060028; GO:0005737; GO:0048546; GO:0009790; GO:0007163; GO:0005615; GO:0008406; GO:0043508; GO:2000057; GO:0090090; GO:0035414; GO:0008285; GO:2000041; GO:0051898; GO:0043433; GO:0090179; GO:0005886; GO:0036342; GO:0001944; GO:0007601 PDZ domain binding; Wnt-activated receptor activity; Wnt-protein binding; anatomical structure morphogenesis; apoptotic process; brain development; cell differentiation; convergent extension involved in axis elongation; cytoplasm; digestive tract morphogenesis; embryo development; establishment or maintenance of cell polarity; extracellular space; gonad development; negative regulation of JUN kinase activity; negative regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of catenin import into nucleus; negative regulation of cell proliferation; negative regulation of planar cell polarity pathway involved in axis elongation; negative regulation of protein kinase B signaling cascade; negative regulation of sequence-specific DNA binding transcription factor activity; planar cell polarity pathway involved in neural tube closure; plasma membrane; post-anal tail morphogenesis; vasculature development; visual perception IPR015526; IPR020067; IPR001134; IPR018933; IPR026559; IPR008993; Secreted frizzled-related protein 5 (sFRP-5) (Frizzled-related protein 1b) (FRP-1b) (Secreted apoptosis-related protein 3) (SARP-3) SFRP5 FRP1B SARP3 Homo sapiens (Human) TR39692_c0_g1_i2 Q61090 FZD7_MOUSE 3.00E-23 GO:0004930; GO:0007199; GO:0030165; GO:0033077; GO:0007223; GO:0042813; GO:0045177; GO:0007409; GO:0007420; GO:0060070; GO:0005737; GO:0009790; GO:0030855; GO:0008406; GO:0016021; GO:0060231; GO:0010812; GO:0042666; GO:0032589; GO:0038031; GO:0060054; GO:0042327; GO:0045893; GO:0035412; GO:0006357; GO:0014834; GO:0048103; GO:0034446; GO:0001944 Q62108 "G-protein coupled receptor activity; G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; PDZ domain binding; T cell differentiation in thymus; Wnt receptor signaling pathway, calcium modulating pathway; Wnt-activated receptor activity; apical part of cell; axonogenesis; brain development; canonical Wnt receptor signaling pathway; cytoplasm; embryo development; epithelial cell differentiation; gonad development; integral to membrane; mesenchymal to epithelial transition; negative regulation of cell-substrate adhesion; negative regulation of ectodermal cell fate specification; neuron projection membrane; non-canonical Wnt receptor signaling pathway via JNK cascade; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of phosphorylation; positive regulation of transcription, DNA-dependent; regulation of catenin import into nucleus; regulation of transcription from RNA polymerase II promoter; satellite cell maintenance involved in skeletal muscle regeneration; somatic stem cell division; substrate adhesion-dependent cell spreading; vasculature development" IPR000539; IPR015526; IPR020067; IPR026552; IPR017981; Frizzled-7 (Fz-7) (mFz7) Fzd7 Mus musculus (Mouse) TR39692_c0_g1_i4 Q5T4F7 SFRP5_HUMAN 2.00E-56 GO:0030165; GO:0042813; GO:0017147; GO:0009653; GO:0006915; GO:0007420; GO:0030154; GO:0060028; GO:0005737; GO:0048546; GO:0009790; GO:0007163; GO:0005615; GO:0008406; GO:0043508; GO:2000057; GO:0090090; GO:0035414; GO:0008285; GO:2000041; GO:0051898; GO:0043433; GO:0090179; GO:0005886; GO:0036342; GO:0001944; GO:0007601 PDZ domain binding; Wnt-activated receptor activity; Wnt-protein binding; anatomical structure morphogenesis; apoptotic process; brain development; cell differentiation; convergent extension involved in axis elongation; cytoplasm; digestive tract morphogenesis; embryo development; establishment or maintenance of cell polarity; extracellular space; gonad development; negative regulation of JUN kinase activity; negative regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of catenin import into nucleus; negative regulation of cell proliferation; negative regulation of planar cell polarity pathway involved in axis elongation; negative regulation of protein kinase B signaling cascade; negative regulation of sequence-specific DNA binding transcription factor activity; planar cell polarity pathway involved in neural tube closure; plasma membrane; post-anal tail morphogenesis; vasculature development; visual perception IPR015526; IPR020067; IPR001134; IPR018933; IPR026559; IPR008993; Secreted frizzled-related protein 5 (sFRP-5) (Frizzled-related protein 1b) (FRP-1b) (Secreted apoptosis-related protein 3) (SARP-3) SFRP5 FRP1B SARP3 Homo sapiens (Human) TR39692_c0_g1_i5 Q8C4U3 SFRP1_MOUSE 5.00E-50 GO:0030165; GO:0090244; GO:0042813; GO:0030036; GO:0006309; GO:0060346; GO:0007420; GO:0060070; GO:0009986; GO:0071773; GO:0071481; GO:0071392; GO:0071391; GO:0044344; GO:0071504; GO:0071456; GO:0071347; GO:0071380; GO:0009267; GO:0071560; GO:0071356; GO:0071305; GO:0090246; GO:0004197; GO:0005737; GO:0005829; GO:0048546; GO:0009950; GO:0008144; GO:0005615; GO:0008585; GO:0002244; GO:0060218; GO:0030097; GO:0008201; GO:0008584; GO:0022601; GO:0045578; GO:0030514; GO:0043508; GO:2000054; GO:0060766; GO:0046851; GO:0090090; GO:2000080; GO:0030308; GO:0030336; GO:2000117; GO:0050680; GO:0010719; GO:2000270; GO:0048147; GO:0010629; GO:0046676; GO:0030279; GO:0045668; GO:0033689; GO:0045671; GO:0050732; GO:2000041; GO:0045892; GO:0014034; GO:0001843; GO:0001649; GO:0090179; GO:0005886; GO:0090263; GO:0030307; GO:0050679; GO:2001238; GO:1902043; GO:0045600; GO:2000271; GO:2000052; GO:0045880; GO:0045893; GO:0060527; GO:0005578; GO:0060687; GO:0010564; GO:0006357; GO:0042493; GO:0035019; GO:0044345; GO:0034446; GO:0001657; GO:0001944 "PDZ domain binding; Wnt receptor signaling pathway involved in somitogenesis; Wnt-activated receptor activity; actin cytoskeleton organization; apoptotic DNA fragmentation; bone trabecula formation; brain development; canonical Wnt receptor signaling pathway; cell surface; cellular response to BMP stimulus; cellular response to X-ray; cellular response to estradiol stimulus; cellular response to estrogen stimulus; cellular response to fibroblast growth factor stimulus; cellular response to heparin; cellular response to hypoxia; cellular response to interleukin-1; cellular response to prostaglandin E stimulus; cellular response to starvation; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; cellular response to vitamin D; convergent extension involved in somitogenesis; cysteine-type endopeptidase activity; cytoplasm; cytosol; digestive tract morphogenesis; dorsal/ventral axis specification; drug binding; extracellular space; female gonad development; hematopoietic progenitor cell differentiation; hematopoietic stem cell differentiation; hemopoiesis; heparin binding; male gonad development; menstrual cycle phase; negative regulation of B cell differentiation; negative regulation of BMP signaling pathway; negative regulation of JUN kinase activity; negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; negative regulation of androgen receptor signaling pathway; negative regulation of bone remodeling; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cysteine-type endopeptidase activity; negative regulation of epithelial cell proliferation; negative regulation of epithelial to mesenchymal transition; negative regulation of fibroblast apoptotic process; negative regulation of fibroblast proliferation; negative regulation of gene expression; negative regulation of insulin secretion; negative regulation of ossification; negative regulation of osteoblast differentiation; negative regulation of osteoblast proliferation; negative regulation of osteoclast differentiation; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of planar cell polarity pathway involved in axis elongation; negative regulation of transcription, DNA-dependent; neural crest cell fate commitment; neural tube closure; osteoblast differentiation; planar cell polarity pathway involved in neural tube closure; plasma membrane; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell growth; positive regulation of epithelial cell proliferation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of fat cell differentiation; positive regulation of fibroblast apoptotic process; positive regulation of non-canonical Wnt receptor signaling pathway; positive regulation of smoothened signaling pathway; positive regulation of transcription, DNA-dependent; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; proteinaceous extracellular matrix; regulation of branching involved in prostate gland morphogenesis; regulation of cell cycle process; regulation of transcription from RNA polymerase II promoter; response to drug; somatic stem cell maintenance; stromal-epithelial cell signaling involved in prostate gland development; substrate adhesion-dependent cell spreading; ureteric bud development; vasculature development" IPR015526; IPR020067; IPR001134; IPR018933; IPR026559; IPR008993; Secreted frizzled-related protein 1 (sFRP-1) Sfrp1 Mus musculus (Mouse) TR39693_c0_g1_i1 P51464 ARLY_LITCT 0 GO:0042450; GO:0004056; GO:0000050 arginine biosynthetic process via ornithine; argininosuccinate lyase activity; urea cycle IPR009049; IPR024083; IPR020557; IPR000362; IPR022761; IPR008948; Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. Nitrogen metabolism; urea cycle; L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1. Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) ASL Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) TR39693_c0_g1_i3 P51464 ARLY_LITCT 0 GO:0042450; GO:0004056; GO:0000050 arginine biosynthetic process via ornithine; argininosuccinate lyase activity; urea cycle IPR009049; IPR024083; IPR020557; IPR000362; IPR022761; IPR008948; Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. Nitrogen metabolism; urea cycle; L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1. Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) ASL Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) TR39695_c2_g1_i1 Q7M3K2 PELET_DROME 3.00E-18 GO:0015074; GO:0003693; GO:0046872; GO:0016740; GO:0004803; GO:0006313 "DNA integration; P-element binding; metal ion binding; transferase activity; transposase activity; transposition, DNA-mediated" IPR022242; IPR021896; IPR006612; Transposable element P transposase (P-element transposase) (EC 2.7.7.-) (THAP domain-containing protein) (DmTHAP) T Drosophila melanogaster (Fruit fly) TR39695_c4_g2_i1 Q2ABP3 PGAP2_RAT 4.00E-46 GO:0006506; GO:0000139; GO:0005789; GO:0016021; GO:0008565 GPI anchor biosynthetic process; Golgi membrane; endoplasmic reticulum membrane; integral to membrane; protein transporter activity IPR019402; Post-GPI attachment to proteins factor 2 (FGF receptor-activating protein 1) Pgap2 Frag1 Rattus norvegicus (Rat) TR39695_c4_g2_i2 Q5BL33 PGAP2_DANRE 4.00E-28 GO:0006506; GO:0000139; GO:0005789; GO:0016021; GO:0008565 GPI anchor biosynthetic process; Golgi membrane; endoplasmic reticulum membrane; integral to membrane; protein transporter activity IPR019402; Post-GPI attachment to proteins factor 2 (FGF receptor-activating protein 1) pgap2 frag1 zgc:101568 Danio rerio (Zebrafish) (Brachydanio rerio) TR39696_c0_g1_i1 O54834 RHG06_MOUSE 1.00E-71 GO:0005100; GO:0015629; GO:0007015; GO:0007202; GO:0005737; GO:0048041; GO:0051895; GO:0051497; GO:0016004; GO:0007165 Rho GTPase activator activity; actin cytoskeleton; actin filament organization; activation of phospholipase C activity; cytoplasm; focal adhesion assembly; negative regulation of focal adhesion assembly; negative regulation of stress fiber assembly; phospholipase activator activity; signal transduction IPR008936; IPR000198; Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) Arhgap6 Mus musculus (Mouse) TR39697_c2_g2_i2 Q10126 YSM6_CAEEL 2.00E-06 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR000477; Putative uncharacterized transposon-derived protein F52C9.6 F52C9.6 Caenorhabditis elegans TR39697_c3_g2_i1 P08548 LIN1_NYCCO 2.00E-21 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR39697_c4_g1_i1 P0C7P3 SLN14_HUMAN 2.00E-06 GO:0005524 ATP binding IPR007421; IPR027417; Schlafen family member 14 SLFN14 Homo sapiens (Human) TR39697_c4_g4_i1 Q96FT7 ASIC4_HUMAN 2.00E-07 GO:0005887; GO:0005216; GO:0005272; GO:0015081 integral to plasma membrane; ion channel activity; sodium channel activity; sodium ion transmembrane transporter activity IPR001873; IPR020903; "Acid-sensing ion channel 4 (ASIC4) (Amiloride-sensitive cation channel 4) (Amiloride-sensitive cation channel 4, pituitary)" ASIC4 ACCN4 Homo sapiens (Human) TR39697_c4_g4_i3 O35240 ASIC3_RAT 3.00E-12 GO:0030165; GO:0005737; GO:0050968; GO:0050966; GO:0050965; GO:0042931; GO:0005887; GO:0015280; GO:0001101; GO:0009408 Q63ZW7-3; Q9JJ19; Q920G2; P54116 PDZ domain binding; cytoplasm; detection of chemical stimulus involved in sensory perception of pain; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; enterobactin transporter activity; integral to plasma membrane; ligand-gated sodium channel activity; response to acid; response to heat IPR004724; IPR001873; IPR020903; Acid-sensing ion channel 3 (ASIC3) (Amiloride-sensitive cation channel 3) (Dorsal root ASIC) (DRASIC) Asic3 Accn3 Drasic Rattus norvegicus (Rat) TR39697_c6_g1_i1 Q588U8 CFDP2_TRAJA 2.00E-12 GO:0005737; GO:0005634 cytoplasm; nucleus IPR005135; IPR027124; Craniofacial development protein 2 (p97 bucentaur protein) CFDP2 BCNT Tragulus javanicus (Lesser Malay chevrotain) (Lesser mouse deer) TR39698_c2_g1_i2 Q8TF66 LRC15_HUMAN 4.00E-06 GO:0016021 integral to membrane IPR000483; IPR001611; IPR025875; IPR003591; IPR000372; Leucine-rich repeat-containing protein 15 (Leucine-rich repeat protein induced by beta-amyloid homolog) (hLib) LRRC15 LIB Homo sapiens (Human) TR39698_c2_g1_i7 Q8TF66 LRC15_HUMAN 2.00E-06 GO:0016021 integral to membrane IPR000483; IPR001611; IPR025875; IPR003591; IPR000372; Leucine-rich repeat-containing protein 15 (Leucine-rich repeat protein induced by beta-amyloid homolog) (hLib) LRRC15 LIB Homo sapiens (Human) TR39700_c1_g3_i1 Q5JDL3 IF2G_PYRKO 3.00E-10 GO:0005525; GO:0006184; GO:0003924; GO:0003746; GO:0003743; GO:0006414 GTP binding; GTP catabolic process; GTPase activity; translation elongation factor activity; translation initiation factor activity; translational elongation IPR000795; IPR027417; IPR005225; IPR022424; IPR015256; IPR009000; IPR009001; IPR004161; Translation initiation factor 2 subunit gamma (aIF2-gamma) (eIF-2-gamma) eif2g TK1946 Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) TR39700_c1_g3_i2 Q9YIC0 EF1A_ORYLA 4.00E-167 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; translation elongation factor activity IPR000795; IPR027417; IPR009000; IPR009001; IPR004539; IPR004161; IPR004160; Elongation factor 1-alpha (EF-1-alpha) eef1a ef1a Oryzias latipes (Medaka fish) (Japanese ricefish) TR39700_c1_g4_i1 Q57771 Y325_METJA 2.00E-07 GO:0005525 GTP binding IPR009000; IPR004161; Uncharacterized protein MJ0325 MJ0325 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR39700_c1_g4_i2 Q07051 EF1A_EIMBO 2.00E-93 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; translation elongation factor activity IPR000795; IPR027417; IPR009000; IPR009001; IPR004161; IPR004160; Elongation factor 1-alpha (EF-1-alpha) (Fragment) Eimeria bovis TR39701_c0_g1_i2 Q9ER41 TOR1B_MOUSE 5.00E-72 GO:0005524; GO:0051085; GO:0005788; GO:0005635; GO:0071763; GO:0017111; GO:0051260 ATP binding; chaperone mediated protein folding requiring cofactor; endoplasmic reticulum lumen; nuclear envelope; nuclear membrane organization; nucleoside-triphosphatase activity; protein homooligomerization IPR003593; IPR027417; IPR010448; IPR017378; Torsin-1B (Torsin family 1 member B) Tor1b Mus musculus (Mouse) TR39703_c0_g1_i1 D2GXS7 TRIM2_AILME 4.00E-22 GO:0005737; GO:0043523; GO:0004842; GO:0008270 cytoplasm; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) TR39703_c0_g1_i3 Q1PSW8 LIN41_MOUSE 6.00E-21 GO:0000082; GO:0000932; GO:0008543; GO:0035198; GO:0010586; GO:0035278; GO:0001843; GO:2000637; GO:0051865; GO:2000177; GO:0072089; GO:0004842; GO:0008270 G1/S transition of mitotic cell cycle; cytoplasmic mRNA processing body; fibroblast growth factor receptor signaling pathway; miRNA binding; miRNA metabolic process; negative regulation of translation involved in gene silencing by miRNA; neural tube closure; positive regulation of gene silencing by miRNA; protein autoubiquitination; regulation of neural precursor cell proliferation; stem cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (mLin41) (Tripartite motif-containing protein 71) Trim71 Gm1127 Lin41 Mus musculus (Mouse) TR39705_c0_g1_i2 P29590 PML_HUMAN 2.00E-10 GO:0003677; GO:0006977; GO:0016605; GO:0030578; GO:0007184; GO:0006919; GO:0006915; GO:0060444; GO:0007050; GO:0045165; GO:0071353; GO:0090398; GO:0050897; GO:0007182; GO:0005737; GO:0005829; GO:0051607; GO:0031901; GO:0032469; GO:0042406; GO:0060333; GO:0008630; GO:0042771; GO:0051457; GO:0019048; GO:0030099; GO:0016525; GO:0030308; GO:0008285; GO:0045930; GO:2000059; GO:0051974; GO:0032211; GO:0045892; GO:0032938; GO:0016363; GO:0031965; GO:0005730; GO:0005634; GO:0060058; GO:0002230; GO:2001238; GO:0031065; GO:0043161; GO:0006461; GO:0046982; GO:0050821; GO:0006605; GO:0045343; GO:0010522; GO:2000779; GO:0001932; GO:0009411; GO:0010332; GO:0001666; GO:0048384; GO:0003713; GO:0006351; GO:0007179; GO:0008270 P03243-1; P04489; P27958; P68400; Q9UER7; P25445; Q9Y2M5; Q13164; Q00987; P25788; P63165; Q13207; O14746; Q15583; P04637; Q05516 "DNA binding; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; PML body; PML body organization; SMAD protein import into nucleus; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; branching involved in mammary gland duct morphogenesis; cell cycle arrest; cell fate commitment; cellular response to interleukin-4; cellular senescence; cobalt ion binding; common-partner SMAD protein phosphorylation; cytoplasm; cytosol; defense response to virus; early endosome membrane; endoplasmic reticulum calcium ion homeostasis; extrinsic to endoplasmic reticulum membrane; interferon-gamma-mediated signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; maintenance of protein location in nucleus; modulation by virus of host morphology or physiology; myeloid cell differentiation; negative regulation of angiogenesis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of mitotic cell cycle; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; negative regulation of telomerase activity; negative regulation of telomere maintenance via telomerase; negative regulation of transcription, DNA-dependent; negative regulation of translation in response to oxidative stress; nuclear matrix; nuclear membrane; nucleolus; nucleus; positive regulation of apoptotic process involved in mammary gland involution; positive regulation of defense response to virus by host; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of histone deacetylation; proteasomal ubiquitin-dependent protein catabolic process; protein complex assembly; protein heterodimerization activity; protein stabilization; protein targeting; regulation of MHC class I biosynthetic process; regulation of calcium ion transport into cytosol; regulation of double-strand break repair; regulation of protein phosphorylation; response to UV; response to gamma radiation; response to hypoxia; retinoic acid receptor signaling pathway; transcription coactivator activity; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; zinc ion binding" IPR021978; IPR000315; IPR001841; IPR013083; IPR017907; Protein PML (Promyelocytic leukemia protein) (RING finger protein 71) (Tripartite motif-containing protein 19) PML MYL PP8675 RNF71 TRIM19 Homo sapiens (Human) TR39706_c0_g2_i3 A1L2L5 PTCD2_XENLA 5.00E-10 GO:0006397; GO:0005739; GO:0050684 mRNA processing; mitochondrion; regulation of mRNA processing IPR002885; IPR019266; "Pentatricopeptide repeat-containing protein 2, mitochondrial" ptcd2 Xenopus laevis (African clawed frog) TR39706_c0_g4_i1 D8VNT0 FCNV4_CERRY 3.00E-27 GO:0005576 extracellular region IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ryncolin-4 Cerberus rynchops (Dog-faced water snake) TR39707_c0_g2_i1 Q6NV26 SDA1_DANRE 5.00E-98 GO:0030036; GO:0005730; GO:0015031; GO:0042273; GO:0000055 actin cytoskeleton organization; nucleolus; protein transport; ribosomal large subunit biogenesis; ribosomal large subunit export from nucleus IPR016024; IPR027312; IPR007949; IPR012977; Protein SDA1 homolog (SDA1 domain-containing protein 1) sdad1 Danio rerio (Zebrafish) (Brachydanio rerio) TR39707_c0_g3_i1 Q9NVU7 SDA1_HUMAN 2.00E-97 GO:0030036; GO:0005730; GO:0015031; GO:0042273; GO:0000055 Q15583 actin cytoskeleton organization; nucleolus; protein transport; ribosomal large subunit biogenesis; ribosomal large subunit export from nucleus IPR016024; IPR027312; IPR007949; IPR012977; Protein SDA1 homolog (Nucleolar protein 130) (SDA1 domain-containing protein 1) (hSDA) SDAD1 NUC130 Homo sapiens (Human) TR39709_c1_g2_i2 Q7ZVP1 JADE3_DANRE 2.00E-66 GO:0008270 zinc ion binding IPR019542; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Protein Jade-3 (PHD finger protein 16) phf16 jade3 Danio rerio (Zebrafish) (Brachydanio rerio) TR39709_c1_g2_i3 Q0P4S5 JADE3_XENTR 3.00E-61 GO:0008270 zinc ion binding IPR019542; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Protein Jade-3 (PHD finger protein 16) phf16 jade3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39709_c1_g2_i4 Q7ZVP1 JADE3_DANRE 5.00E-64 GO:0008270 zinc ion binding IPR019542; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Protein Jade-3 (PHD finger protein 16) phf16 jade3 Danio rerio (Zebrafish) (Brachydanio rerio) TR39712_c1_g2_i1 O43390 HNRPR_HUMAN 3.00E-146 GO:0003723; GO:0071013; GO:0005737; GO:0000398; GO:0005654; GO:0000166 P16333 "RNA binding; catalytic step 2 spliceosome; cytoplasm; mRNA splicing, via spliceosome; nucleoplasm; nucleotide binding" IPR006535; IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein R (hnRNP R) HNRNPR HNRPR Homo sapiens (Human) TR39713_c1_g1_i1 Q14596 NBR1_HUMAN 8.00E-10 GO:0031430; GO:0005776; GO:0031410; GO:0005829; GO:0005770; GO:0005764; GO:0016236; GO:0051019; GO:0045668; GO:0000407; GO:0051259; GO:0030500; GO:0032872; GO:0043130; GO:0008270 P38182; O95166; Q9H0R8; P60520; P42858; Q9H492; Q9GZQ8; Q9BXW4; Q13501; P40818 M band; autophagic vacuole; cytoplasmic vesicle; cytosol; late endosome; lysosome; macroautophagy; mitogen-activated protein kinase binding; negative regulation of osteoblast differentiation; pre-autophagosomal structure; protein oligomerization; regulation of bone mineralization; regulation of stress-activated MAPK cascade; ubiquitin binding; zinc ion binding IPR000270; IPR009060; IPR015940; IPR000433; Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) NBR1 1A13B KIAA0049 M17S2 MIG19 Homo sapiens (Human) TR39713_c1_g1_i3 Q14596 NBR1_HUMAN 1.00E-09 GO:0031430; GO:0005776; GO:0031410; GO:0005829; GO:0005770; GO:0005764; GO:0016236; GO:0051019; GO:0045668; GO:0000407; GO:0051259; GO:0030500; GO:0032872; GO:0043130; GO:0008270 P38182; O95166; Q9H0R8; P60520; P42858; Q9H492; Q9GZQ8; Q9BXW4; Q13501; P40818 M band; autophagic vacuole; cytoplasmic vesicle; cytosol; late endosome; lysosome; macroautophagy; mitogen-activated protein kinase binding; negative regulation of osteoblast differentiation; pre-autophagosomal structure; protein oligomerization; regulation of bone mineralization; regulation of stress-activated MAPK cascade; ubiquitin binding; zinc ion binding IPR000270; IPR009060; IPR015940; IPR000433; Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) NBR1 1A13B KIAA0049 M17S2 MIG19 Homo sapiens (Human) TR39715_c0_g1_i1 Q9UKK3 PARP4_HUMAN 5.00E-22 GO:0003677; GO:0006281; GO:0003950; GO:0008219; GO:0005737; GO:0019899; GO:0006954; GO:0005634; GO:0006471; GO:0042493; GO:0030529; GO:0005876; GO:0006810 Q9Q2G4 DNA binding; DNA repair; NAD+ ADP-ribosyltransferase activity; cell death; cytoplasm; enzyme binding; inflammatory response; nucleus; protein ADP-ribosylation; response to drug; ribonucleoprotein complex; spindle microtubule; transport IPR001357; IPR012317; IPR004102; IPR013694; IPR002035; Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) TR39715_c0_g2_i1 Q75WE7 VWA5A_RAT 7.00E-68 IPR013694; IPR002035; von Willebrand factor A domain-containing protein 5A (Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog) (Mast cell surface antigen 1) (Masa-1) Vwa5a Loh11cr2a Masa1 Rattus norvegicus (Rat) TR39715_c0_g2_i2 Q99KC8 VMA5A_MOUSE 3.00E-65 IPR013694; IPR002035; von Willebrand factor A domain-containing protein 5A (Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog) Vwa5a Loh11cr2a Mus musculus (Mouse) TR39716_c0_g1_i1 Q8VZS9 FZR1_ARATH 4.00E-151 GO:0051301; GO:0005737; GO:0010492; GO:0007067; GO:0005634; GO:0032877; GO:0016567; GO:0008361 Q8LGU6 cell division; cytoplasm; maintenance of shoot apical meristem identity; mitosis; nucleus; positive regulation of DNA endoreduplication; protein ubiquitination; regulation of cell size IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. Protein FIZZY-RELATED 1 (Cell cycle switch protein CCS52A2) FZR1 CCS52A2 CDH1-1 At4g11920 T26M18.130 Arabidopsis thaliana (Mouse-ear cress) TR39716_c0_g1_i2 Q9R1K5 FZR_MOUSE 0 GO:0006281; GO:0031572; GO:0051488; GO:0005680; GO:0031145; GO:0051301; GO:0070306; GO:0007067; GO:0090344; GO:0031965; GO:0008284; GO:0045732; GO:0016567; GO:0040020 Q8VDQ8 DNA repair; G2 DNA damage checkpoint; activation of anaphase-promoting complex activity; anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; lens fiber cell differentiation; mitosis; negative regulation of cell aging; nuclear membrane; positive regulation of cell proliferation; positive regulation of protein catabolic process; protein ubiquitination; regulation of meiosis IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. Fizzy-related protein homolog (Fzr) (Cdh1/Hct1 homolog) Fzr1 Fyr Fzr Mus musculus (Mouse) TR39716_c0_g1_i3 Q8YRI1 YY46_NOSS1 3.00E-21 GO:0006355 "regulation of transcription, DNA-dependent" IPR001646; IPR020472; IPR007111; IPR027417; IPR011047; IPR027728; IPR015943; IPR001680; IPR019775; IPR017986; Uncharacterized WD repeat-containing protein alr3466 alr3466 Nostoc sp. (strain PCC 7120 / UTEX 2576) TR39716_c0_g1_i4 Q9R1K5 FZR_MOUSE 0 GO:0006281; GO:0031572; GO:0051488; GO:0005680; GO:0031145; GO:0051301; GO:0070306; GO:0007067; GO:0090344; GO:0031965; GO:0008284; GO:0045732; GO:0016567; GO:0040020 Q8VDQ8 DNA repair; G2 DNA damage checkpoint; activation of anaphase-promoting complex activity; anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; lens fiber cell differentiation; mitosis; negative regulation of cell aging; nuclear membrane; positive regulation of cell proliferation; positive regulation of protein catabolic process; protein ubiquitination; regulation of meiosis IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. Fizzy-related protein homolog (Fzr) (Cdh1/Hct1 homolog) Fzr1 Fyr Fzr Mus musculus (Mouse) TR39716_c0_g1_i5 P50082 AMA1_YEAST 5.00E-24 GO:0005680; GO:0030476; GO:0051301; GO:0008047; GO:0007127; GO:0045732 anaphase-promoting complex; ascospore wall assembly; cell division; enzyme activator activity; meiosis I; positive regulation of protein catabolic process IPR015943; IPR001680; IPR017986; Meiosis-specific APC/C activator protein AMA1 (Activator of meiotic APC/C protein 1) (Sporulation-specific protein 70) AMA1 SPO70 YGR225W G8541 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39716_c0_g1_i6 Q54KM3 CDH1_DICDI 9.00E-80 GO:0051301; GO:0007067; GO:0005634; GO:0016567 cell division; mitosis; nucleus; protein ubiquitination IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. Anaphase-promoting complex subunit cdh1 cdh1 DDB_G0287259 Dictyostelium discoideum (Slime mold) TR39716_c0_g1_i7 A2CEH0 POC1B_DANRE 3.00E-09 GO:0042384; GO:0060287; GO:0003014 cilium assembly; epithelial cilium movement involved in determination of left/right asymmetry; renal system process IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; POC1 centriolar protein homolog B (WD repeat domain 51B) poc1b tuwd12 wdr51b si:dkey-164B12.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR39718_c1_g1_i1 Q4P4N1 ATG18_USTMA 2.00E-69 GO:0006914; GO:0010008; GO:0034045; GO:0015031; GO:0005774 autophagy; endosome membrane; pre-autophagosomal structure membrane; protein transport; vacuolar membrane IPR015943; IPR001680; IPR017986; Autophagy-related protein 18 ATG18 UM04932 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR39718_c1_g1_i3 Q5ZHN3 WIPI2_CHICK 0 GO:0000045; GO:0000421; GO:0005829; GO:0005634; GO:0080025; GO:0032266; GO:0034045; GO:0043234 "autophagic vacuole assembly; autophagic vacuole membrane; cytosol; nucleus; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding; pre-autophagosomal structure membrane; protein complex" IPR015943; IPR001680; IPR017986; WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) WIPI2 RCJMB04_35d18 Gallus gallus (Chicken) TR39719_c11_g1_i1 Q8N0N9 ODH_HALDH 6.00E-156 GO:0051287; GO:0005737; GO:0046168; GO:0016616 "NAD binding; cytoplasm; glycerol-3-phosphate catabolic process; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" IPR008927; IPR013328; IPR011128; IPR016040; IPR003421; Opine dehydrogenase (EC 1.5.1.-) tadh Haliotis discus hannai (Japanese abalone) TR39721_c3_g1_i1 P83732 RL24_RAT 4.00E-30 GO:0022625; GO:0003735; GO:0006412 cytosolic large ribosomal subunit; structural constituent of ribosome; translation IPR023442; IPR023441; IPR000988; IPR011017; 60S ribosomal protein L24 (L30) Rpl24 Rattus norvegicus (Rat) TR39721_c3_g1_i2 O22165 RLP24_ARATH 2.00E-07 GO:0022625; GO:0005730; GO:0042254 cytosolic large ribosomal subunit; nucleolus; ribosome biogenesis IPR023442; IPR023441; IPR000988; IPR011017; Probable ribosome biogenesis protein RLP24 At2g44860 T13E15.13 Arabidopsis thaliana (Mouse-ear cress) TR39722_c2_g1_i1 O43760 SNG2_HUMAN 6.00E-52 GO:0016021; GO:0006605; GO:0008021 integral to membrane; protein targeting; synaptic vesicle IPR008253; IPR016579; Synaptogyrin-2 (Cellugyrin) SYNGR2 UNQ352/PRO615 Homo sapiens (Human) TR39723_c0_g1_i2 Q55G11 NCSEB_DICDI 0 GO:0017040; GO:0006672; GO:0005576 ceramidase activity; ceramide metabolic process; extracellular region IPR006823; Neutral ceramidase B (N-CDase B) (NCDase B) (EC 3.5.1.23) (Acylsphingosine deacylase 2B) (N-acylsphingosine amidohydrolase 2B) dcd2B DDB_G0268374 Dictyostelium discoideum (Slime mold) TR39724_c2_g1_i2 Q6P829 NOSIP_XENTR 2.00E-108 GO:0005737; GO:0005634 cytoplasm; nucleus IPR016818; IPR013083; Nitric oxide synthase-interacting protein nosip Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39724_c2_g1_i4 Q6NUH3 NOSIP_XENLA 6.00E-111 GO:0005737; GO:0005634 cytoplasm; nucleus IPR016818; IPR013083; Nitric oxide synthase-interacting protein nosip Xenopus laevis (African clawed frog) TR39725_c4_g2_i1 Q07076 ANXA7_MOUSE 1.00E-88 GO:0005509; GO:0005544; GO:0008283; GO:0006874; GO:0009992; GO:0042584; GO:0005829; GO:0005789; GO:0007599; GO:0005635; GO:0005886; GO:0008360; GO:0009651; GO:0035176; GO:0031982 calcium ion binding; calcium-dependent phospholipid binding; cell proliferation; cellular calcium ion homeostasis; cellular water homeostasis; chromaffin granule membrane; cytosol; endoplasmic reticulum membrane; hemostasis; nuclear envelope; plasma membrane; regulation of cell shape; response to salt stress; social behavior; vesicle IPR001464; IPR018502; IPR018252; IPR013286; Annexin A7 (Annexin VII) (Annexin-7) (Synexin) Anxa7 Anx7 Mus musculus (Mouse) TR39725_c4_g2_i2 Q9C9X3 ANXD5_ARATH 1.00E-19 GO:0005509; GO:0005544; GO:0009409; GO:0009408; GO:0009639; GO:0009651; GO:0009414 calcium ion binding; calcium-dependent phospholipid binding; response to cold; response to heat; response to red or far red light; response to salt stress; response to water deprivation IPR001464; IPR009118; IPR018502; IPR018252; Annexin D5 (AnnAt5) ANN5 ANNAT5 At1g68090 T23K23.6 Arabidopsis thaliana (Mouse-ear cress) TR39727_c0_g1_i1 P49793 NUP98_RAT 8.00E-164 GO:0006260; GO:0000776; GO:0051028; GO:0042405; GO:0031965; GO:0034399; GO:0051292; GO:0044615; GO:0031080; GO:0005654; GO:0042277; GO:0000059; GO:0017056 "DNA replication; kinetochore; mRNA transport; nuclear inclusion body; nuclear membrane; nuclear periphery; nuclear pore complex assembly; nuclear pore nuclear basket; nuclear pore outer ring; nucleoplasm; peptide binding; protein import into nucleus, docking; structural constituent of nuclear pore" IPR021967; IPR007230; Nuclear pore complex protein Nup98-Nup96 [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] Nup98 Rattus norvegicus (Rat) TR39728_c2_g1_i1 Q9BEA9 GSTM3_MACFU 7.00E-60 GO:0005737; GO:0006749; GO:0004364 cytoplasm; glutathione metabolic process; glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR003081; IPR012336; Glutathione S-transferase Mu 3 (EC 2.5.1.18) (GST class-mu 3) (GSTM3-3) GSTM3 Macaca fuscata fuscata (Japanese macaque) TR39728_c2_g1_i3 P46425 GSTP2_MOUSE 1.00E-24 GO:0006749; GO:0004364 glutathione metabolic process; glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR003082; IPR012336; Glutathione S-transferase P 2 (Gst P2) (EC 2.5.1.18) (GST YF-YF) (GST class-pi) (GST-piA) Gstp2 Gstpia Mus musculus (Mouse) TR39729_c1_g2_i2 P11369 POL2_MOUSE 2.00E-15 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR013544; IPR005135; IPR000477; Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element-1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] Pol Gm17492 Mus musculus (Mouse) TR39730_c0_g1_i2 Q28F51 TADBP_XENTR 1.00E-103 GO:0003677; GO:0003723; GO:0008380; GO:0006397; GO:0000166; GO:0005634; GO:0006355; GO:0006351 "DNA binding; RNA binding; RNA splicing; mRNA processing; nucleotide binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR012677; IPR000504; TAR DNA-binding protein 43 (TDP-43) tardbp tdp43 TGas087d21.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39731_c3_g1_i1 Q2VPU4 MLXIP_MOUSE 6.00E-22 GO:0003677; GO:0005737; GO:0005741; GO:0006913; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cytoplasm; mitochondrial outer membrane; nucleocytoplasmic transport; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011598; MLX-interacting protein (Transcriptional activator MondoA) Mlxip Mir Mus musculus (Mouse) TR39731_c3_g1_i4 Q2VPU4 MLXIP_MOUSE 2.00E-37 GO:0003677; GO:0005737; GO:0005741; GO:0006913; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cytoplasm; mitochondrial outer membrane; nucleocytoplasmic transport; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011598; MLX-interacting protein (Transcriptional activator MondoA) Mlxip Mir Mus musculus (Mouse) TR39732_c1_g1_i1 Q9I8E6 COPG2_TAKRU 0 GO:0030126; GO:0006886; GO:0005198; GO:0016192 COPI vesicle coat; intracellular protein transport; structural molecule activity; vesicle-mediated transport IPR011989; IPR016024; IPR002553; IPR015873; IPR009028; IPR013041; IPR017106; IPR013040; Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP) copg2 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR39732_c1_g1_i3 Q9I8E6 COPG2_TAKRU 0 GO:0030126; GO:0006886; GO:0005198; GO:0016192 COPI vesicle coat; intracellular protein transport; structural molecule activity; vesicle-mediated transport IPR011989; IPR016024; IPR002553; IPR015873; IPR009028; IPR013041; IPR017106; IPR013040; Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP) copg2 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR39733_c4_g2_i3 Q8BMI4 GEN_MOUSE 1.00E-64 GO:0003677; GO:0006281; GO:0004519; GO:0046872; GO:0090305; GO:0005634 DNA binding; DNA repair; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleus IPR020045; IPR008918; IPR006086; IPR006084; IPR006085; Flap endonuclease GEN homolog 1 (EC 3.1.-.-) Gen1 Mus musculus (Mouse) TR39735_c0_g1_i1 Q8IXY8 PPIL6_HUMAN 2.00E-38 GO:0003755; GO:0006457; GO:0000413 peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; Peptidyl-prolyl cis-trans isomerase-like 6 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL6) (Rotamase PPIL6) PPIL6 Homo sapiens (Human) TR39735_c0_g1_i3 Q2TZ33 PPIH_ASPOR 2.00E-25 GO:0005634; GO:0003755; GO:0006457; GO:0000413 nucleus; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC 5.2.1.8) (Rotamase H) cyp3 AO090103000002 Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) TR39735_c0_g1_i5 Q9ASS6 CP20B_ARATH 6.00E-27 GO:0010275; GO:0031969; GO:0009533; GO:0009543; GO:0009535; GO:0042277; GO:0003755; GO:0006457; GO:0031977 Q9C5U2 NAD(P)H dehydrogenase complex assembly; chloroplast membrane; chloroplast stromal thylakoid; chloroplast thylakoid lumen; chloroplast thylakoid membrane; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein folding; thylakoid lumen IPR002130; IPR020892; "Peptidyl-prolyl cis-trans isomerase CYP20-2, chloroplastic (PPIase CYP20-2) (EC 5.2.1.8) (Cyclophilin of 20 kDa 2) (Rotamase CYP20-2) (Thylakoid lumen PPIase of 20 kDa) (TLP20)" CYP20-2 At5g13120 T19L5_80 Arabidopsis thaliana (Mouse-ear cress) TR39735_c0_g2_i2 Q9D6D8 PPIL6_MOUSE 6.00E-51 GO:0003755; GO:0006457; GO:0000413 peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; Peptidyl-prolyl cis-trans isomerase-like 6 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL6) (Rotamase PPIL6) Ppil6 Mus musculus (Mouse) TR39736_c1_g2_i1 O70244 CUBN_RAT 1.00E-25 GO:0031526; GO:0005509; GO:0008203; GO:0031419; GO:0030666; GO:0010008; GO:0030492; GO:0020028; GO:0042802; GO:0001701; GO:0043202; GO:0005765; GO:0043234; GO:0070207; GO:0004872; GO:0006898; GO:0007584; GO:0006766 Itself brush border membrane; calcium ion binding; cholesterol metabolic process; cobalamin binding; endocytic vesicle membrane; endosome membrane; hemoglobin binding; hemoglobin import; identical protein binding; in utero embryonic development; lysosomal lumen; lysosomal membrane; protein complex; protein homotrimerization; receptor activity; receptor-mediated endocytosis; response to nutrient; vitamin metabolic process IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; Cubilin (460 kDa receptor) (Glycoprotein 280) (gp280) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) Cubn Ifcr Rattus norvegicus (Rat) TR39736_c1_g2_i2 Q9JLB4 CUBN_MOUSE 2.00E-21 GO:0005794; GO:0016324; GO:0005903; GO:0005509; GO:0008203; GO:0005905; GO:0031419; GO:0030139; GO:0005783; GO:0005768; GO:0010008; GO:0042953; GO:0005765; GO:0004872; GO:0006898 Golgi apparatus; apical plasma membrane; brush border; calcium ion binding; cholesterol metabolic process; coated pit; cobalamin binding; endocytic vesicle; endoplasmic reticulum; endosome; endosome membrane; lipoprotein transport; lysosomal membrane; receptor activity; receptor-mediated endocytosis IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; Cubilin (Intrinsic factor-cobalamin receptor) Cubn Ifcr Mus musculus (Mouse) TR39736_c1_g2_i3 Q9WVM6 TLL2_MOUSE 1.00E-12 GO:0005509; GO:0030154; GO:0005576; GO:0004222; GO:0007275; GO:0006508; GO:0008270 calcium ion binding; cell differentiation; extracellular region; metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Tolloid-like protein 2 (EC 3.4.24.-) Tll2 Mus musculus (Mouse) TR39739_c6_g5_i2 B4PST0 HTRA2_DROYA 9.00E-93 GO:0006915; GO:0016021; GO:0005758; GO:0031966; GO:0006508; GO:0004252 apoptotic process; integral to membrane; mitochondrial intermembrane space; mitochondrial membrane; proteolysis; serine-type endopeptidase activity IPR001478; IPR001940; IPR009003; "Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2)" HtrA2 GE26447 Drosophila yakuba (Fruit fly) TR39740_c1_g1_i1 Q9LU92 TGT4_ARATH 3.00E-06 GO:0003682; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "chromatin binding; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR027775; IPR009057; IPR017877; IPR028002; IPR001005; IPR027759; Trihelix transcription factor GT-4 (Trihelix DNA-binding protein GT-4) GT-4 At3g25990 MPE11.20 Arabidopsis thaliana (Mouse-ear cress) TR39740_c1_g1_i3 Q9C882 GTL1_ARATH 2.00E-06 GO:0003677; GO:0042631; GO:0003682; GO:0032876; GO:0030308; GO:0045892; GO:0005634; GO:0008361; GO:2000038; GO:2000037; GO:0009414; GO:0043565; GO:0003700; GO:0006351; GO:0010090 "DNA binding; cellular response to water deprivation; chromatin binding; negative regulation of DNA endoreduplication; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; nucleus; regulation of cell size; regulation of stomatal complex development; regulation of stomatal complex patterning; response to water deprivation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; trichome morphogenesis" IPR017877; IPR001005; Trihelix transcription factor GTL1 (GT2-LIKE protein 1) (AtGTL1) (Protein GT-2-LIKE1) (Trihelix DNA-binding protein GTL1) GTL1 At1g33240 T16O9.10 T9L6.10 Arabidopsis thaliana (Mouse-ear cress) TR39740_c1_g1_i4 Q9C882 GTL1_ARATH 2.00E-06 GO:0003677; GO:0042631; GO:0003682; GO:0032876; GO:0030308; GO:0045892; GO:0005634; GO:0008361; GO:2000038; GO:2000037; GO:0009414; GO:0043565; GO:0003700; GO:0006351; GO:0010090 "DNA binding; cellular response to water deprivation; chromatin binding; negative regulation of DNA endoreduplication; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; nucleus; regulation of cell size; regulation of stomatal complex development; regulation of stomatal complex patterning; response to water deprivation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; trichome morphogenesis" IPR017877; IPR001005; Trihelix transcription factor GTL1 (GT2-LIKE protein 1) (AtGTL1) (Protein GT-2-LIKE1) (Trihelix DNA-binding protein GTL1) GTL1 At1g33240 T16O9.10 T9L6.10 Arabidopsis thaliana (Mouse-ear cress) TR39740_c1_g1_i5 Q9LU92 TGT4_ARATH 5.00E-06 GO:0003682; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "chromatin binding; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR027775; IPR009057; IPR017877; IPR028002; IPR001005; IPR027759; Trihelix transcription factor GT-4 (Trihelix DNA-binding protein GT-4) GT-4 At3g25990 MPE11.20 Arabidopsis thaliana (Mouse-ear cress) TR39742_c3_g1_i1 Q4G0S4 C27C1_HUMAN 2.00E-25 GO:0020037; GO:0005506; GO:0016020; GO:0004497; GO:0016705 "heme binding; iron ion binding; membrane; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Cytochrome P450 27C1 (EC 1.14.-.-) CYP27C1 Homo sapiens (Human) TR39742_c3_g2_i1 Q09128 CP24A_RAT 3.00E-32 GO:0030342; GO:0008403; GO:0020037; GO:0005506; GO:0005739; GO:0001649; GO:0033280; GO:0042369 "1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; heme binding; iron ion binding; mitochondrion; osteoblast differentiation; response to vitamin D; vitamin D catabolic process" IPR001128; IPR017972; IPR002949; "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.13.126) (Cytochrome P450 24A1) (Cytochrome P450-CC24)" Cyp24a1 Cyp24 Rattus norvegicus (Rat) TR39744_c0_g1_i2 Q9GKT2 CE004_MACFA 4.00E-125 GO:0006633; GO:0016021; GO:0005506; GO:0016491 fatty acid biosynthetic process; integral to membrane; iron ion binding; oxidoreductase activity IPR006694; Fatty acid hydroxylase domain-containing protein 2 FAXDC2 QccE-20373 QflA-14437 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR39746_c0_g1_i2 Q99715 COCA1_HUMAN 3.00E-18 GO:0007155; GO:0030574; GO:0030199; GO:0005595; GO:0005788; GO:0022617; GO:0030020; GO:0005615; GO:0070062; GO:0001501 cell adhesion; collagen catabolic process; collagen fibril organization; collagen type XII; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular matrix structural constituent conferring tensile strength; extracellular space; extracellular vesicular exosome; skeletal system development IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) TR39746_c0_g1_i3 Q9UKX5 ITA11_HUMAN 5.00E-06 GO:0007155; GO:0007160; GO:0005518; GO:0008305; GO:0007229; GO:0046872; GO:0007517 cell adhesion; cell-matrix adhesion; collagen binding; integrin complex; integrin-mediated signaling pathway; metal ion binding; muscle organ development IPR013517; IPR013519; IPR000413; IPR013649; IPR002035; Integrin alpha-11 ITGA11 MSTP018 Homo sapiens (Human) TR39746_c0_g1_i6 Q9QXH4 ITAX_MOUSE 2.00E-14 GO:0007155; GO:0051607; GO:0009897; GO:0008305; GO:0007229; GO:0046872 cell adhesion; defense response to virus; external side of plasma membrane; integrin complex; integrin-mediated signaling pathway; metal ion binding IPR013517; IPR013519; IPR000413; IPR013649; IPR018184; IPR002035; "Integrin alpha-X (CD11 antigen-like family member C) (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (CD antigen CD11c)" Itgax Mus musculus (Mouse) TR39746_c0_g1_i7 Q9UKX5 ITA11_HUMAN 4.00E-06 GO:0007155; GO:0007160; GO:0005518; GO:0008305; GO:0007229; GO:0046872; GO:0007517 cell adhesion; cell-matrix adhesion; collagen binding; integrin complex; integrin-mediated signaling pathway; metal ion binding; muscle organ development IPR013517; IPR013519; IPR000413; IPR013649; IPR002035; Integrin alpha-11 ITGA11 MSTP018 Homo sapiens (Human) TR39746_c0_g1_i8 Q99715 COCA1_HUMAN 3.00E-18 GO:0007155; GO:0030574; GO:0030199; GO:0005595; GO:0005788; GO:0022617; GO:0030020; GO:0005615; GO:0070062; GO:0001501 cell adhesion; collagen catabolic process; collagen fibril organization; collagen type XII; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular matrix structural constituent conferring tensile strength; extracellular space; extracellular vesicular exosome; skeletal system development IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) TR39746_c0_g1_i9 Q9QXH4 ITAX_MOUSE 2.00E-14 GO:0007155; GO:0051607; GO:0009897; GO:0008305; GO:0007229; GO:0046872 cell adhesion; defense response to virus; external side of plasma membrane; integrin complex; integrin-mediated signaling pathway; metal ion binding IPR013517; IPR013519; IPR000413; IPR013649; IPR018184; IPR002035; "Integrin alpha-X (CD11 antigen-like family member C) (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (CD antigen CD11c)" Itgax Mus musculus (Mouse) TR39747_c1_g1_i1 P54748 PDE4A_RAT 9.00E-11 GO:0004115; GO:0006198; GO:0046872; GO:0005634; GO:0048471; GO:0042493; GO:0007165 "3',5'-cyclic-AMP phosphodiesterase activity; cAMP catabolic process; metal ion binding; nucleus; perinuclear region of cytoplasm; response to drug; signal transduction" IPR003607; IPR023088; IPR002073; IPR023174; "Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1." "cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.53) (DPDE2)" Pde4a Rattus norvegicus (Rat) TR39747_c2_g1_i1 Q9QXQ1 PDE7B_MOUSE 4.00E-08 GO:0004115; GO:0006198; GO:0046872; GO:0007165 "3',5'-cyclic-AMP phosphodiesterase activity; cAMP catabolic process; metal ion binding; signal transduction" IPR003607; IPR023088; IPR002073; IPR023174; "Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1." "cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.53)" Pde7b Mus musculus (Mouse) TR39747_c2_g2_i1 Q9Y233 PDE10_HUMAN 1.00E-16 GO:0047555; GO:0007596; GO:0030552; GO:0006198; GO:0030553; GO:0046069; GO:0004118; GO:0005829; GO:0046872; GO:0043949; GO:0010738; GO:0007165 "3',5'-cyclic-GMP phosphodiesterase activity; blood coagulation; cAMP binding; cAMP catabolic process; cGMP binding; cGMP catabolic process; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cytosol; metal ion binding; regulation of cAMP-mediated signaling; regulation of protein kinase A signaling cascade; signal transduction" IPR003018; IPR003607; IPR023088; IPR002073; IPR023174; "Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1." "cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17) (EC 3.1.4.35)" PDE10A Homo sapiens (Human) TR39747_c6_g1_i1 Q922S4 PDE2A_MOUSE 2.00E-51 GO:0036004; GO:0005794; GO:0030424; GO:0030552; GO:0006198; GO:0019933; GO:0030553; GO:0046069; GO:0019934; GO:0004118; GO:0071321; GO:0035690; GO:0097011; GO:0071222; GO:0036006; GO:0071260; GO:0005829; GO:0030425; GO:0008144; GO:0005783; GO:0061028; GO:0016020; GO:0046872; GO:0005759; GO:0030818; GO:0033159; GO:0000122; GO:0043116; GO:0005634; GO:0048471; GO:0005886; GO:0010628; GO:0050729; GO:0043117; GO:0042734; GO:0042803; GO:0006626 "GAF domain binding; Golgi apparatus; axon; cAMP binding; cAMP catabolic process; cAMP-mediated signaling; cGMP binding; cGMP catabolic process; cGMP-mediated signaling; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cellular response to cGMP; cellular response to drug; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cellular response to lipopolysaccharide; cellular response to macrophage colony-stimulating factor stimulus; cellular response to mechanical stimulus; cytosol; dendrite; drug binding; endoplasmic reticulum; establishment of endothelial barrier; membrane; metal ion binding; mitochondrial matrix; negative regulation of cAMP biosynthetic process; negative regulation of protein import into nucleus, translocation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of vascular permeability; nucleus; perinuclear region of cytoplasm; plasma membrane; positive regulation of gene expression; positive regulation of inflammatory response; positive regulation of vascular permeability; presynaptic membrane; protein homodimerization activity; protein targeting to mitochondrion" IPR003018; IPR003607; IPR023088; IPR002073; IPR023174; "cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)" Pde2a Mus musculus (Mouse) TR39748_c0_g3_i1 P42669 PURA_MOUSE 8.00E-76 GO:0005662; GO:0006268; GO:0046332; GO:0006915; GO:0030154; GO:0008283; GO:0005737; GO:0030425; GO:0003690; GO:0003691; GO:0007093; GO:0045892; GO:0007399; GO:0043025; GO:0008284; GO:0032422; GO:0003700; GO:0003697; GO:0006351; GO:0000900 "DNA replication factor A complex; DNA unwinding involved in DNA replication; SMAD binding; apoptotic process; cell differentiation; cell proliferation; cytoplasm; dendrite; double-stranded DNA binding; double-stranded telomeric DNA binding; mitotic cell cycle checkpoint; negative regulation of transcription, DNA-dependent; nervous system development; neuronal cell body; positive regulation of cell proliferation; purine-rich negative regulatory element binding; sequence-specific DNA binding transcription factor activity; single-stranded DNA binding; transcription, DNA-dependent; translation repressor activity, nucleic acid binding" IPR006628; Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha) Pura Mus musculus (Mouse) TR39748_c0_g3_i2 Q9UJV8 PURG_HUMAN 5.00E-58 GO:0003677; GO:0005634 DNA binding; nucleus IPR006628; Purine-rich element-binding protein gamma PURG Homo sapiens (Human) TR39748_c0_g3_i3 Q6PHK6 PURB_DANRE 1.00E-76 GO:0003677; GO:0005634; GO:0006355; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006628; Transcriptional activator protein Pur-beta (Purine-rich element-binding protein B) purb Danio rerio (Zebrafish) (Brachydanio rerio) TR39749_c0_g1_i1 Q86W34 AMZ2_HUMAN 2.00E-33 GO:0008237; GO:0006508; GO:0008270 metallopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR012962; Archaemetzincin-2 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 2) AMZ2 BM-014 Homo sapiens (Human) TR39749_c1_g1_i1 P05400 POL_CERV 2.00E-08 GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR000588; IPR000477; Enzymatic polyprotein [Includes: Aspartic protease (EC 3.4.23.-); Endonuclease; Reverse transcriptase (EC 2.7.7.49)] ORF V Carnation etched ring virus (CERV) TR39749_c1_g1_i2 O50655 XERD_SELRU 1.00E-09 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR39749_c1_g1_i3 O50655 XERD_SELRU 1.00E-09 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR39749_c2_g2_i1 A5PK19 MET13_BOVIN 4.00E-68 GO:0008168 methyltransferase activity IPR013216; IPR001045; Methyltransferase-like protein 13 (EC 2.1.1.-) METTL13 Bos taurus (Bovine) TR39750_c0_g1_i3 A9KRZ4 EFTU_CLOPH 1.00E-06 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; translation elongation factor activity IPR000795; IPR027417; IPR005225; IPR009000; IPR009001; IPR004161; IPR004541; IPR004160; Elongation factor Tu (EF-Tu) tuf Cphy_0238 Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) TR39750_c0_g1_i4 D2XV59 GTPB1_RAT 0 GO:0005525; GO:0003924; GO:0000177; GO:0005829; GO:0061014 GTP binding; GTPase activity; cytoplasmic exosome (RNase complex); cytosol; positive regulation of mRNA catabolic process IPR000795; IPR027417; IPR009000; IPR009001; IPR004161; IPR004160; GTP-binding protein 1 Gtpbp1 Rattus norvegicus (Rat) TR39751_c6_g1_i2 Q8K5B3 MCFD2_RAT 7.00E-26 GO:0005794; GO:0005509; GO:0019752; GO:0005783; GO:0005793; GO:0005576; GO:0015031; GO:0016192 Golgi apparatus; calcium ion binding; carboxylic acid metabolic process; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; extracellular region; protein transport; vesicle-mediated transport IPR011992; IPR018247; IPR002048; Multiple coagulation factor deficiency protein 2 homolog (Neural stem cell-derived neuronal survival protein) Mcfd2 Sdnsf Rattus norvegicus (Rat) TR39751_c6_g1_i6 Q8K5B3 MCFD2_RAT 8.00E-26 GO:0005794; GO:0005509; GO:0019752; GO:0005783; GO:0005793; GO:0005576; GO:0015031; GO:0016192 Golgi apparatus; calcium ion binding; carboxylic acid metabolic process; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; extracellular region; protein transport; vesicle-mediated transport IPR011992; IPR018247; IPR002048; Multiple coagulation factor deficiency protein 2 homolog (Neural stem cell-derived neuronal survival protein) Mcfd2 Sdnsf Rattus norvegicus (Rat) TR39752_c3_g2_i1 Q8BMA3 CNKR3_MOUSE 4.00E-15 GO:0005737; GO:0016020; GO:0070373; GO:0033137; GO:2000651; GO:0010765 cytoplasm; membrane; negative regulation of ERK1 and ERK2 cascade; negative regulation of peptidyl-serine phosphorylation; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport IPR010599; IPR017874; IPR019555; IPR001478; IPR001660; IPR013761; IPR021129; Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein) Cnksr3 Mus musculus (Mouse) TR39752_c3_g3_i4 Q5DU31 ICEF1_MOUSE 5.00E-25 GO:0005737; GO:0005543; GO:0005886 cytoplasm; phospholipid binding; plasma membrane IPR011993; IPR001849; Interactor protein for cytohesin exchange factors 1 Ipcef1 Kiaa0403 Mus musculus (Mouse) TR39752_c3_g3_i6 Q8WWN9 ICEF1_HUMAN 1.00E-28 GO:0005737; GO:0005344; GO:0004601; GO:0005543; GO:0005886; GO:0006979 cytoplasm; oxygen transporter activity; peroxidase activity; phospholipid binding; plasma membrane; response to oxidative stress IPR011993; IPR001849; Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E) IPCEF1 KIAA0403 Homo sapiens (Human) TR39752_c3_g3_i7 Q80YA9 CNKR2_MOUSE 3.00E-27 GO:0005737; GO:0043005; GO:0043025; GO:0005543; GO:0045211; GO:0009966 cytoplasm; neuron projection; neuronal cell body; phospholipid binding; postsynaptic membrane; regulation of signal transduction IPR010599; IPR017874; IPR019555; IPR001478; IPR011993; IPR001849; IPR001660; IPR013761; IPR021129; Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) Cnksr2 Kiaa0902 Mus musculus (Mouse) TR39753_c0_g1_i1 P30907 AL3A1_BOVIN 1.00E-72 GO:0004030; GO:0006081; GO:0005737 aldehyde dehydrogenase [NAD(P)+] activity; cellular aldehyde metabolic process; cytoplasm IPR016161; IPR016163; IPR016160; IPR015590; IPR012394; "Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (Aldehyde dehydrogenase 3) (Aldehyde dehydrogenase family 3 member A1) (Corneal 15.8 kDa protein) (Corneal protein 54) (bCP54) (Transparentin) (Fragment)" ALDH3A1 ALDH3 Bos taurus (Bovine) TR39753_c0_g2_i1 Q60HH8 AL3A2_MACFA 5.00E-159 GO:0004029; GO:0004030; GO:0006081; GO:0005789; GO:0016021 aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; cellular aldehyde metabolic process; endoplasmic reticulum membrane; integral to membrane IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR012394; Fatty aldehyde dehydrogenase (EC 1.2.1.3) (Aldehyde dehydrogenase family 3 member A2) ALDH3A2 QccE-15682 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR39753_c0_g2_i2 Q5XI42 AL3B1_RAT 5.00E-168 GO:0004030; GO:0006081; GO:0005829; GO:0006068; GO:0005886 aldehyde dehydrogenase [NAD(P)+] activity; cellular aldehyde metabolic process; cytosol; ethanol catabolic process; plasma membrane IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR012394; Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. Aldehyde dehydrogenase family 3 member B1 (EC 1.2.1.5) Aldh3b1 Rattus norvegicus (Rat) TR39753_c0_g2_i4 P43353 AL3B1_HUMAN 5.00E-105 GO:0004028; GO:0006066; GO:0046185; GO:0004030; GO:0034599; GO:0005737; GO:0005829; GO:0006068; GO:0006629; GO:0005886 3-chloroallyl aldehyde dehydrogenase activity; alcohol metabolic process; aldehyde catabolic process; aldehyde dehydrogenase [NAD(P)+] activity; cellular response to oxidative stress; cytoplasm; cytosol; ethanol catabolic process; lipid metabolic process; plasma membrane IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR012394; Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. Aldehyde dehydrogenase family 3 member B1 (EC 1.2.1.5) (Aldehyde dehydrogenase 7) ALDH3B1 ALDH7 Homo sapiens (Human) TR39755_c2_g1_i1 P30876 RPB2_HUMAN 0 GO:0006370; GO:0003677; GO:0005665; GO:0003899; GO:0003682; GO:0000398; GO:0046872; GO:0050434; GO:0032549; GO:0006368; GO:0006367; GO:0006283; GO:0016032 "7-methylguanosine mRNA capping; DNA binding; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase activity; chromatin binding; mRNA splicing, via spliceosome; metal ion binding; positive regulation of viral transcription; ribonucleoside binding; transcription elongation from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair; viral process" IPR015712; IPR007120; IPR007121; IPR007644; IPR007642; IPR007645; IPR007646; IPR007647; IPR007641; IPR014724; DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) POLR2B Homo sapiens (Human) TR39755_c2_g1_i2 P30876 RPB2_HUMAN 0 GO:0006370; GO:0003677; GO:0005665; GO:0003899; GO:0003682; GO:0000398; GO:0046872; GO:0050434; GO:0032549; GO:0006368; GO:0006367; GO:0006283; GO:0016032 "7-methylguanosine mRNA capping; DNA binding; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase activity; chromatin binding; mRNA splicing, via spliceosome; metal ion binding; positive regulation of viral transcription; ribonucleoside binding; transcription elongation from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair; viral process" IPR015712; IPR007120; IPR007121; IPR007644; IPR007642; IPR007645; IPR007646; IPR007647; IPR007641; IPR014724; DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) POLR2B Homo sapiens (Human) TR39756_c0_g2_i1 Q7T3P8 FEM1C_DANRE 7.00E-40 GO:0005737; GO:0016567 cytoplasm; protein ubiquitination IPR002110; IPR020683; IPR011990; Protein modification; protein ubiquitination. Protein fem-1 homolog C (FEM1c) (FEM1-gamma) fem1c Danio rerio (Zebrafish) (Brachydanio rerio) TR39756_c0_g2_i3 Q5UPA0 YL025_MIMIV 2.00E-08 IPR002110; IPR020683; Putative ankyrin repeat protein L25 MIMI_L25 Acanthamoeba polyphaga mimivirus (APMV) TR39756_c0_g2_i4 Q9H2K2 TNKS2_HUMAN 3.00E-07 GO:0000139; GO:0003950; GO:0016055; GO:0046872; GO:0035264; GO:0000784; GO:0005635; GO:0000242; GO:0048471; GO:0090263; GO:0032212; GO:0070213; GO:0070198; GO:0000209; GO:0040014 O15084; O15169; Q9NWV8; P11274; Q6V0I7; Q9NWT6; Q92698; P78314; Q06649; O43815; P54274 "Golgi membrane; NAD+ ADP-ribosyltransferase activity; Wnt receptor signaling pathway; metal ion binding; multicellular organism growth; nuclear chromosome, telomeric region; nuclear envelope; pericentriolar material; perinuclear region of cytoplasm; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of telomere maintenance via telomerase; protein auto-ADP-ribosylation; protein localization to chromosome, telomeric region; protein polyubiquitination; regulation of multicellular organism growth" IPR002110; IPR020683; IPR012317; IPR001660; IPR013761; IPR011510; Tankyrase-2 (TANK2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-like protein) (Tankyrase-related protein) TNKS2 PARP5B TANK2 TNKL Homo sapiens (Human) TR39756_c0_g2_i5 Q29RM5 FEM1A_BOVIN 7.00E-36 GO:0005737; GO:0050728; GO:0051438; GO:0004842 cytoplasm; negative regulation of inflammatory response; regulation of ubiquitin-protein ligase activity; ubiquitin-protein ligase activity IPR002110; IPR020683; IPR011990; Protein modification; protein ubiquitination. Protein fem-1 homolog A (FEM1a) (FEM1-alpha) FEM1A Bos taurus (Bovine) TR39756_c0_g2_i6 Q3SX45 ASB2_BOVIN 1.00E-07 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 2 (ASB-2) ASB2 Bos taurus (Bovine) TR39756_c0_g2_i7 Q7T3P8 FEM1C_DANRE 2.00E-40 GO:0005737; GO:0016567 cytoplasm; protein ubiquitination IPR002110; IPR020683; IPR011990; Protein modification; protein ubiquitination. Protein fem-1 homolog C (FEM1c) (FEM1-gamma) fem1c Danio rerio (Zebrafish) (Brachydanio rerio) TR39757_c3_g1_i1 Q9P7M0 YOS3_SCHPO 7.00E-11 GO:0016021; GO:0016301; GO:0031966 integral to membrane; kinase activity; mitochondrial membrane IPR011009; IPR004147; "ABC1 family protein C21C3.03, mitochondrial" SPBC21C3.03 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR39757_c3_g1_i2 Q9D0L4 ADCK1_MOUSE 0 GO:0005524; GO:0005576; GO:0005739; GO:0004674 ATP binding; extracellular region; mitochondrion; protein serine/threonine kinase activity IPR011009; IPR000719; IPR004147; Uncharacterized aarF domain-containing protein kinase 1 (EC 2.7.11.-) Adck1 Mus musculus (Mouse) TR39758_c3_g2_i1 Q03936 ZNF92_HUMAN 2.00E-45 GO:0003677; GO:0005634; GO:0003700; GO:0006351; GO:0008270 "DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 92 (Zinc finger protein HTF12) ZNF92 Homo sapiens (Human) TR39758_c3_g2_i2 A6NK53 ZN233_HUMAN 2.00E-55 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 233 ZNF233 Homo sapiens (Human) TR39758_c3_g2_i3 Q02526 ZFP41_MOUSE 1.00E-25 GO:0003677; GO:0030154; GO:0046872; GO:0007275; GO:0005634; GO:0006355; GO:0007283; GO:0006351 "DNA binding; cell differentiation; metal ion binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; spermatogenesis; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 41 (Zfp-41) (CtFIN92) Zfp41 Zfp-41 Mus musculus (Mouse) TR39758_c3_g2_i4 A0JNB1 ZN227_BOVIN 5.00E-52 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 227 ZNF227 Bos taurus (Bovine) TR39758_c3_g2_i5 Q9UJU3 ZF112_HUMAN 1.00E-33 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 112 (Zfp-112) (Zinc finger protein 228) ZNF112 ZFP112 ZNF228 Homo sapiens (Human) TR39758_c3_g2_i6 A6NK53 ZN233_HUMAN 4.00E-35 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 233 ZNF233 Homo sapiens (Human) TR39759_c1_g1_i1 O54967 ACK1_MOUSE 2.00E-166 GO:0005524; GO:0005912; GO:0030424; GO:0030136; GO:0005905; GO:0030659; GO:0030425; GO:0006897; GO:0005768; GO:0030426; GO:0046872; GO:0043025; GO:0004715; GO:0005634; GO:0018108; GO:0005886; GO:0004674 ATP binding; adherens junction; axon; clathrin-coated vesicle; coated pit; cytoplasmic vesicle membrane; dendrite; endocytosis; endosome; growth cone; metal ion binding; neuronal cell body; non-membrane spanning protein tyrosine kinase activity; nucleus; peptidyl-tyrosine phosphorylation; plasma membrane; protein serine/threonine kinase activity IPR015116; IPR021619; IPR011009; IPR000719; IPR017441; IPR001245; IPR001452; IPR008266; IPR020635; IPR009060; IPR000449; Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2) Tnk2 Ack1 Mus musculus (Mouse) TR3976_c1_g1_i1 Q9P0L9 PK2L1_HUMAN 2.00E-06 GO:0005262; GO:0005509; GO:0015269; GO:0009986; GO:0071468; GO:0001581; GO:0050982; GO:0005783; GO:0042802; GO:0016021; GO:0005886; GO:0005272; GO:0033040 calcium channel activity; calcium ion binding; calcium-activated potassium channel activity; cell surface; cellular response to acidity; detection of chemical stimulus involved in sensory perception of sour taste; detection of mechanical stimulus; endoplasmic reticulum; identical protein binding; integral to membrane; plasma membrane; sodium channel activity; sour taste receptor activity IPR011992; IPR013122; IPR003915; Polycystic kidney disease 2-like 1 protein (Polycystin-2 homolog) (Polycystin-2L1) (Polycystin-L) (Polycystin-L1) PKD2L1 PKD2L PKDL Homo sapiens (Human) TR39760_c3_g1_i1 Q8BZW8 NHLC2_MOUSE 1.00E-112 IPR011042; IPR000033; IPR001258; IPR012336; NHL repeat-containing protein 2 Nhlrc2 Mus musculus (Mouse) TR39760_c3_g1_i2 Q03601 NHL1_CAEEL 2.00E-06 GO:0008270 G5EFS1; O62482 zinc ion binding IPR011042; IPR001258; IPR013017; IPR018957; IPR001841; IPR013083; IPR017907; RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans TR39760_c3_g1_i3 Q8BZW8 NHLC2_MOUSE 0 IPR011042; IPR000033; IPR001258; IPR012336; NHL repeat-containing protein 2 Nhlrc2 Mus musculus (Mouse) TR39761_c0_g1_i1 Q8NUZ4 FLP_STAAW 3.00E-14 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR001466; IPR012338; Protein flp (FmtA-like protein) flp MW2365 Staphylococcus aureus (strain MW2) TR39761_c0_g1_i2 Q8NUZ4 FLP_STAAW 2.00E-11 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR001466; IPR012338; Protein flp (FmtA-like protein) flp MW2365 Staphylococcus aureus (strain MW2) TR39763_c1_g3_i1 Q00546 TENR_CHICK 5.00E-49 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR013032; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin-R (TN-R) (Restrictin) TNR Gallus gallus (Chicken) TR39763_c1_g3_i8 P57756 FCN2_RAT 1.00E-47 GO:0005581; GO:0001867 "collagen; complement activation, lectin pathway" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) Fcn2 Fcnb Rattus norvegicus (Rat) TR39764_c0_g1_i2 P59999 ARPC4_MOUSE 8.00E-91 GO:0034314; GO:0005885; GO:0030041; GO:0042995; GO:0005737 Arp2/3 complex-mediated actin nucleation; Arp2/3 protein complex; actin filament polymerization; cell projection; cytoplasm IPR008384; Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) Arpc4 Arc20 Mus musculus (Mouse) TR39764_c0_g1_i3 P59999 ARPC4_MOUSE 4.00E-97 GO:0034314; GO:0005885; GO:0030041; GO:0042995; GO:0005737 Arp2/3 complex-mediated actin nucleation; Arp2/3 protein complex; actin filament polymerization; cell projection; cytoplasm IPR008384; Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) Arpc4 Arc20 Mus musculus (Mouse) TR39766_c2_g3_i1 P08548 LIN1_NYCCO 4.00E-43 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR39767_c0_g2_i1 Q2KIR0 CD045_BOVIN 3.00E-14 IPR027814; Uncharacterized protein C4orf45 homolog Bos taurus (Bovine) TR39767_c0_g2_i5 Q2KIR0 CD045_BOVIN 4.00E-14 IPR027814; Uncharacterized protein C4orf45 homolog Bos taurus (Bovine) TR39769_c2_g1_i1 Q61097 KSR1_MOUSE 2.00E-107 GO:0005524; GO:0005078; GO:0005789; GO:0035556; GO:0046872; GO:0043410; GO:0004674 P15056; P15531; Q86Y07-1 ATP binding; MAP-kinase scaffold activity; endoplasmic reticulum membrane; intracellular signal transduction; metal ion binding; positive regulation of MAPK cascade; protein serine/threonine kinase activity IPR011009; IPR025561; IPR002219; IPR000719; IPR001245; IPR008271; Kinase suppressor of Ras 1 (mKSR1) (Protein Hb) Ksr1 Ksr Mus musculus (Mouse) TR39769_c2_g1_i2 Q61097 KSR1_MOUSE 2.00E-107 GO:0005524; GO:0005078; GO:0005789; GO:0035556; GO:0046872; GO:0043410; GO:0004674 P15056; P15531; Q86Y07-1 ATP binding; MAP-kinase scaffold activity; endoplasmic reticulum membrane; intracellular signal transduction; metal ion binding; positive regulation of MAPK cascade; protein serine/threonine kinase activity IPR011009; IPR025561; IPR002219; IPR000719; IPR001245; IPR008271; Kinase suppressor of Ras 1 (mKSR1) (Protein Hb) Ksr1 Ksr Mus musculus (Mouse) TR39769_c2_g1_i4 P10398 ARAF_HUMAN 3.00E-58 GO:0005524; GO:0004709; GO:0005829; GO:0046872; GO:0005739; GO:0043066; GO:0033138; GO:0004674; GO:0032006; GO:0032434 P00966; Q9UNS2; P31327; Q12805; P08238; O43187; Q92985; P36507; Q8IXH7; O95848; Q96KB5; O94906; P53611; P62070; O43615; Q3ZCQ8; P58753; P63104 ATP binding; MAP kinase kinase kinase activity; cytosol; metal ion binding; mitochondrion; negative regulation of apoptotic process; positive regulation of peptidyl-serine phosphorylation; protein serine/threonine kinase activity; regulation of TOR signaling cascade; regulation of proteasomal ubiquitin-dependent protein catabolic process IPR020454; IPR011009; IPR002219; IPR000719; IPR017441; IPR003116; IPR001245; IPR008271; Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) ARAF ARAF1 PKS PKS2 Homo sapiens (Human) TR39769_c2_g1_i5 Q61097 KSR1_MOUSE 2.00E-111 GO:0005524; GO:0005078; GO:0005789; GO:0035556; GO:0046872; GO:0043410; GO:0004674 P15056; P15531; Q86Y07-1 ATP binding; MAP-kinase scaffold activity; endoplasmic reticulum membrane; intracellular signal transduction; metal ion binding; positive regulation of MAPK cascade; protein serine/threonine kinase activity IPR011009; IPR025561; IPR002219; IPR000719; IPR001245; IPR008271; Kinase suppressor of Ras 1 (mKSR1) (Protein Hb) Ksr1 Ksr Mus musculus (Mouse) TR39769_c2_g1_i6 Q03526 ITK_MOUSE 5.00E-20 GO:0005524; GO:0001865; GO:0050852; GO:0007202; GO:0002250; GO:0005829; GO:0032609; GO:0032633; GO:0035556; GO:0046872; GO:0004715; GO:0005543 ATP binding; NK T cell differentiation; T cell receptor signaling pathway; activation of phospholipase C activity; adaptive immune response; cytosol; interferon-gamma production; interleukin-4 production; intracellular signal transduction; metal ion binding; non-membrane spanning protein tyrosine kinase activity; phospholipid binding IPR011009; IPR011993; IPR001849; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; IPR001562; Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) (T-cell-specific kinase) Itk Emt Tlk Tsk Mus musculus (Mouse) TR39770_c2_g1_i1 O02485 YDJ1_CAEEL 1.00E-68 IPR004142; Uncharacterized protein ZK1073.1 ZK1073.1 Caenorhabditis elegans TR39770_c2_g1_i10 Q92597 NDRG1_HUMAN 4.00E-43 GO:0030330; GO:0017137; GO:0045296; GO:0005913; GO:0071456; GO:0005813; GO:0005829; GO:0043015; GO:0045576; GO:0005874; GO:0008017; GO:0005634; GO:0048471; GO:0032287; GO:0005886; GO:0090232; GO:0055038; GO:0010038 P27824; P12956 "DNA damage response, signal transduction by p53 class mediator; Rab GTPase binding; cadherin binding; cell-cell adherens junction; cellular response to hypoxia; centrosome; cytosol; gamma-tubulin binding; mast cell activation; microtubule; microtubule binding; nucleus; perinuclear region of cytoplasm; peripheral nervous system myelin maintenance; plasma membrane; positive regulation of spindle checkpoint; recycling endosome membrane; response to metal ion" IPR004142; Protein NDRG1 (Differentiation-related gene 1 protein) (DRG-1) (N-myc downstream-regulated gene 1 protein) (Nickel-specific induction protein Cap43) (Reducing agents and tunicamycin-responsive protein) (RTP) (Rit42) NDRG1 CAP43 DRG1 RTP Homo sapiens (Human) TR39770_c2_g1_i11 O02485 YDJ1_CAEEL 8.00E-74 IPR004142; Uncharacterized protein ZK1073.1 ZK1073.1 Caenorhabditis elegans TR39770_c2_g1_i2 Q62433 NDRG1_MOUSE 6.00E-38 GO:0030330; GO:0005913; GO:0071456; GO:0005813; GO:0005737; GO:0005829; GO:0045576; GO:0005874; GO:0005634; GO:0048471; GO:0032287; GO:0005886; GO:0090232; GO:0055038 "DNA damage response, signal transduction by p53 class mediator; cell-cell adherens junction; cellular response to hypoxia; centrosome; cytoplasm; cytosol; mast cell activation; microtubule; nucleus; perinuclear region of cytoplasm; peripheral nervous system myelin maintenance; plasma membrane; positive regulation of spindle checkpoint; recycling endosome membrane" IPR004142; Protein NDRG1 (N-myc downstream-regulated gene 1 protein) (Protein Ndr1) Ndrg1 Ndr1 Ndrl Tdd5 Mus musculus (Mouse) TR39770_c2_g1_i3 Q55BX3 NDRG_DICDI 4.00E-23 IPR004142; NDRG-like protein DDB_G0270324 Dictyostelium discoideum (Slime mold) TR39770_c2_g1_i5 O02485 YDJ1_CAEEL 8.00E-69 IPR004142; Uncharacterized protein ZK1073.1 ZK1073.1 Caenorhabditis elegans TR39770_c2_g1_i6 Q62433 NDRG1_MOUSE 1.00E-40 GO:0030330; GO:0005913; GO:0071456; GO:0005813; GO:0005737; GO:0005829; GO:0045576; GO:0005874; GO:0005634; GO:0048471; GO:0032287; GO:0005886; GO:0090232; GO:0055038 "DNA damage response, signal transduction by p53 class mediator; cell-cell adherens junction; cellular response to hypoxia; centrosome; cytoplasm; cytosol; mast cell activation; microtubule; nucleus; perinuclear region of cytoplasm; peripheral nervous system myelin maintenance; plasma membrane; positive regulation of spindle checkpoint; recycling endosome membrane" IPR004142; Protein NDRG1 (N-myc downstream-regulated gene 1 protein) (Protein Ndr1) Ndrg1 Ndr1 Ndrl Tdd5 Mus musculus (Mouse) TR39770_c2_g1_i7 O02485 YDJ1_CAEEL 5.00E-71 IPR004142; Uncharacterized protein ZK1073.1 ZK1073.1 Caenorhabditis elegans TR39771_c0_g1_i1 Q98ST7 MOXD1_CHICK 4.00E-34 GO:0006584; GO:0005507; GO:0004500; GO:0005789; GO:0016021 catecholamine metabolic process; copper ion binding; dopamine beta-monooxygenase activity; endoplasmic reticulum membrane; integral to membrane IPR014784; IPR000323; IPR000945; IPR005018; IPR008977; DBH-like monooxygenase protein 1 (EC 1.14.17.-) (DBH-related protein) (Monooxygenase X) MOXD1 DBHR MOX Gallus gallus (Chicken) TR39771_c0_g1_i2 Q7Z0T3 TEMPT_APLCA 2.00E-35 GO:0005576 extracellular region Temptin Aplysia californica (California sea hare) TR39772_c0_g1_i3 Q92733 PRCC_HUMAN 3.00E-28 GO:0007093; GO:0005634 mitotic cell cycle checkpoint; nucleus IPR018800; Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) PRCC TPRC Homo sapiens (Human) TR39772_c0_g1_i5 Q92733 PRCC_HUMAN 5.00E-28 GO:0007093; GO:0005634 mitotic cell cycle checkpoint; nucleus IPR018800; Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) PRCC TPRC Homo sapiens (Human) TR39773_c0_g1_i1 Q80X66 BTBDA_MOUSE 1.00E-140 GO:0005634 nucleus IPR000210; IPR011333; BTB/POZ domain-containing protein 10 Btbd10 Mus musculus (Mouse) TR39774_c0_g1_i2 Q68CP4 HGNAT_HUMAN 2.00E-92 GO:0005975; GO:0006027; GO:0015019; GO:0016021; GO:0005765; GO:0007041; GO:0051259; GO:0044281; GO:0016746 "carbohydrate metabolic process; glycosaminoglycan catabolic process; heparan-alpha-glucosaminide N-acetyltransferase activity; integral to membrane; lysosomal membrane; lysosomal transport; protein oligomerization; small molecule metabolic process; transferase activity, transferring acyl groups" IPR012429; Heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) (Transmembrane protein 76) HGSNAT TMEM76 Homo sapiens (Human) TR39777_c5_g2_i2 Q7TPV2 DZIP3_MOUSE 2.00E-10 GO:0003723; GO:0005737; GO:0016874; GO:0019902; GO:0016567; GO:0008270 RNA binding; cytoplasm; ligase activity; phosphatase binding; protein ubiquitination; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog) Dzip3 Kiaa0675 Mus musculus (Mouse) TR39777_c5_g2_i3 Q86Y13 DZIP3_HUMAN 2.00E-07 GO:0003723; GO:0005737; GO:0019902; GO:0031593; GO:0000209; GO:0004842; GO:0008270 Q9H0E2 RNA binding; cytoplasm; phosphatase binding; polyubiquitin binding; protein polyubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) TR39777_c5_g2_i4 Q7TPV2 DZIP3_MOUSE 4.00E-10 GO:0003723; GO:0005737; GO:0016874; GO:0019902; GO:0016567; GO:0008270 RNA binding; cytoplasm; ligase activity; phosphatase binding; protein ubiquitination; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog) Dzip3 Kiaa0675 Mus musculus (Mouse) TR39778_c6_g1_i2 Q15154 PCM1_HUMAN 9.00E-46 GO:0000086; GO:0034451; GO:0051297; GO:0042384; GO:0005829; GO:0042802; GO:0022027; GO:0034453; GO:0034454; GO:0050768; GO:0097150; GO:0031965; GO:0000242; GO:0071539 Q8NFJ9; Q96RK4 G2/M transition of mitotic cell cycle; centriolar satellite; centrosome organization; cilium assembly; cytosol; identical protein binding; interkinetic nuclear migration; microtubule anchoring; microtubule anchoring at centrosome; negative regulation of neurogenesis; neuronal stem cell maintenance; nuclear membrane; pericentriolar material; protein localization to centrosome IPR024138; Pericentriolar material 1 protein (PCM-1) (hPCM-1) PCM1 Homo sapiens (Human) TR39778_c8_g1_i1 Q26486 FKBP4_SPOFR 2.00E-19 GO:0003677; GO:0005528; GO:0000412; GO:0005730; GO:0003755; GO:0006457 DNA binding; FK506 binding; histone peptidyl-prolyl isomerization; nucleolus; peptidyl-prolyl cis-trans isomerase activity; protein folding IPR026257; IPR023566; IPR001179; 46 kDa FK506-binding nuclear protein (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) FKBP46 Spodoptera frugiperda (Fall armyworm) TR39778_c8_g1_i4 Q26486 FKBP4_SPOFR 4.00E-21 GO:0003677; GO:0005528; GO:0000412; GO:0005730; GO:0003755; GO:0006457 DNA binding; FK506 binding; histone peptidyl-prolyl isomerization; nucleolus; peptidyl-prolyl cis-trans isomerase activity; protein folding IPR026257; IPR023566; IPR001179; 46 kDa FK506-binding nuclear protein (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) FKBP46 Spodoptera frugiperda (Fall armyworm) TR39779_c8_g2_i1 Q29RU2 OIT3_BOVIN 1.00E-20 GO:0005509; GO:0005635 calcium ion binding; nuclear envelope IPR000742; IPR000152; IPR018097; IPR009030; IPR001507; Oncoprotein-induced transcript 3 protein OIT3 Bos taurus (Bovine) TR39779_c8_g2_i6 Q4A3R3 DMBT1_PIG 2.00E-14 GO:0030154; GO:0005576; GO:0019898; GO:0016021; GO:0007275; GO:0015031; GO:0005044; GO:0030658; GO:0035375; GO:0042589 cell differentiation; extracellular region; extrinsic to membrane; integral to membrane; multicellular organismal development; protein transport; scavenger receptor activity; transport vesicle membrane; zymogen binding; zymogen granule membrane IPR000859; IPR001190; IPR017448; IPR001507; IPR017977; Deleted in malignant brain tumors 1 protein (Hensin) DMBT1 Sus scrofa (Pig) TR39781_c0_g1_i1 Q0VRL1 SYP_ALCBS 3.00E-30 GO:0005524; GO:0002161; GO:0005737; GO:0004827; GO:0006433; GO:0006450 ATP binding; aminoacyl-tRNA editing activity; cytoplasm; proline-tRNA ligase activity; prolyl-tRNA aminoacylation; regulation of translational fidelity IPR002314; IPR006195; IPR004154; IPR002316; IPR004500; IPR023717; IPR007214; Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS) proS ABO_0739 Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) TR39781_c0_g1_i2 Q8CFI5 SYPM_MOUSE 2.00E-72 GO:0005524; GO:0005759; GO:0005739; GO:0004827; GO:0006433 ATP binding; mitochondrial matrix; mitochondrion; proline-tRNA ligase activity; prolyl-tRNA aminoacylation IPR002314; IPR006195; IPR004154; IPR002316; IPR004500; "Probable proline--tRNA ligase, mitochondrial (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)" Pars2 Mus musculus (Mouse) TR39781_c0_g1_i3 Q8CFI5 SYPM_MOUSE 1.00E-71 GO:0005524; GO:0005759; GO:0005739; GO:0004827; GO:0006433 ATP binding; mitochondrial matrix; mitochondrion; proline-tRNA ligase activity; prolyl-tRNA aminoacylation IPR002314; IPR006195; IPR004154; IPR002316; IPR004500; "Probable proline--tRNA ligase, mitochondrial (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)" Pars2 Mus musculus (Mouse) TR39781_c0_g2_i2 P43830 SYP_HAEIN 5.00E-54 GO:0005524; GO:0002161; GO:0005737; GO:0004827; GO:0006433; GO:0006450 ATP binding; aminoacyl-tRNA editing activity; cytoplasm; proline-tRNA ligase activity; prolyl-tRNA aminoacylation; regulation of translational fidelity IPR002314; IPR006195; IPR004154; IPR002316; IPR004500; IPR023717; IPR007214; Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS) proS HI_0729 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) TR39781_c1_g2_i1 P63240 NEC1_MUSCO 0 GO:0006508; GO:0004252; GO:0030133 proteolysis; serine-type endopeptidase activity; transport vesicle IPR008979; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR022005; IPR009020; IPR002884; Neuroendocrine convertase 1 (NEC 1) (EC 3.4.21.93) (Furin homolog) (PC3) (Prohormone convertase 1) (Propeptide-processing protease) (Proprotein convertase 1) (PC1) Pcsk1 Att-1 Nec-1 Nec1 Mus cookii (Cook's mouse) TR39782_c3_g1_i1 Q9WUP7 UCHL5_MOUSE 2.00E-151 GO:0006310; GO:0006281; GO:0031011; GO:0005829; GO:0004866; GO:0048853; GO:0021670; GO:0030901; GO:0005634; GO:0008242; GO:0000502; GO:0016579; GO:0061136; GO:0006355; GO:0006351; GO:0004221; GO:0006511; GO:0004843 "DNA recombination; DNA repair; Ino80 complex; cytosol; endopeptidase inhibitor activity; forebrain morphogenesis; lateral ventricle development; midbrain development; nucleus; omega peptidase activity; proteasome complex; protein deubiquitination; regulation of proteasomal protein catabolic process; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity" IPR001578; IPR017390; Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5) Uchl5 Uch37 Mus musculus (Mouse) TR39782_c3_g1_i2 Q00981 UCHL1_RAT 5.00E-10 GO:0007628; GO:0030424; GO:0007412; GO:0019896; GO:0008283; GO:0004197; GO:0005829; GO:0042755; GO:0005789; GO:0016874; GO:0048747; GO:0043407; GO:0050905; GO:0043025; GO:0005634; GO:0008242; GO:0005886; GO:0016579; GO:0006950; GO:0019233; GO:0004221; GO:0006511 adult walking behavior; axon; axon target recognition; axon transport of mitochondrion; cell proliferation; cysteine-type endopeptidase activity; cytosol; eating behavior; endoplasmic reticulum membrane; ligase activity; muscle fiber development; negative regulation of MAP kinase activity; neuromuscular process; neuronal cell body; nucleus; omega peptidase activity; plasma membrane; protein deubiquitination; response to stress; sensory perception of pain; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR001578; Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (EC 6.-.-.-) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1) Uchl1 Rattus norvegicus (Rat) TR39782_c3_g1_i4 B4JW98 CALYP_DROGR 2.00E-50 GO:0035517; GO:0003682; GO:0006342; GO:0035522; GO:0000790; GO:0004221; GO:0006511; GO:0004843 PR-DUB complex; chromatin binding; chromatin silencing; monoubiquitinated histone H2A deubiquitination; nuclear chromatin; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR001578; Ubiquitin carboxyl-terminal hydrolase calypso (EC 3.4.19.12) (BAP1 homolog) calypso GH22997 Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) TR39782_c3_g1_i5 Q9WUP7 UCHL5_MOUSE 2.00E-153 GO:0006310; GO:0006281; GO:0031011; GO:0005829; GO:0004866; GO:0048853; GO:0021670; GO:0030901; GO:0005634; GO:0008242; GO:0000502; GO:0016579; GO:0061136; GO:0006355; GO:0006351; GO:0004221; GO:0006511; GO:0004843 "DNA recombination; DNA repair; Ino80 complex; cytosol; endopeptidase inhibitor activity; forebrain morphogenesis; lateral ventricle development; midbrain development; nucleus; omega peptidase activity; proteasome complex; protein deubiquitination; regulation of proteasomal protein catabolic process; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity" IPR001578; IPR017390; Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5) Uchl5 Uch37 Mus musculus (Mouse) TR39785_c0_g1_i1 Q9D1F4 AKTS1_MOUSE 3.00E-06 GO:0007219; GO:0031931; GO:0005829; GO:0032007; GO:0045792; GO:0006469; GO:0048011; GO:0043523 Notch signaling pathway; TORC1 complex; cytosol; negative regulation of TOR signaling cascade; negative regulation of cell size; negative regulation of protein kinase activity; neurotrophin TRK receptor signaling pathway; regulation of neuron apoptotic process IPR026682; Proline-rich AKT1 substrate 1 (Proline-rich AKT substrate) Akt1s1 Pras Mus musculus (Mouse) TR39787_c6_g1_i2 Q7XA48 DODA_PORGR 9.00E-31 GO:0006725; GO:0005737; GO:0008198; GO:0050297; GO:0008270 cellular aromatic compound metabolic process; cytoplasm; ferrous iron binding; stizolobate synthase activity; zinc ion binding IPR014436; IPR004183; Pigment biosynthesis; betalain biosynthesis. "4,5-DOPA dioxygenase extradiol (EC 1.13.11.29)" DODA Portulaca grandiflora (Rose moss) TR39787_c6_g1_i4 Q949R4 DIOXL_ARATH 1.00E-39 GO:0006725; GO:0051213; GO:0008198; GO:0016701; GO:0008270 "cellular aromatic compound metabolic process; dioxygenase activity; ferrous iron binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen; zinc ion binding" IPR014436; IPR004183; Extradiol ring-cleavage dioxygenase (AtLigB) (EC 1.13.11.-) LIGB At4g15093 dl3590w Arabidopsis thaliana (Mouse-ear cress) TR39787_c7_g1_i2 Q5ZIG0 NCDN_CHICK 4.00E-62 GO:0005829; GO:0030425; GO:0031175; GO:0043025 cytosol; dendrite; neuron projection development; neuronal cell body IPR008709; Neurochondrin NCDN RCJMB04_26k21 Gallus gallus (Chicken) TR39792_c2_g2_i1 P0CP90 PPIL2_CRYNJ 2.00E-22 GO:0005634; GO:0003755; GO:0006457; GO:0000413 nucleus; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR020892; IPR026951; IPR013083; Peptidyl-prolyl cis-trans isomerase-like 2 (PPIase) (EC 5.2.1.8) (Cyclophilin-60) (Cyclophilin-like protein Cyp-60) (Rotamase) CYP8 CNJ00200 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR39792_c2_g2_i2 Q4IBK5 PPIL2_GIBZE 7.00E-25 GO:0005634; GO:0003755; GO:0006457; GO:0000413 nucleus; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR020892; IPR026951; IPR013083; Peptidyl-prolyl cis-trans isomerase-like 2 (PPIase) (EC 5.2.1.8) (Cyclophilin-60) (Cyclophilin-like protein Cyp-60) (Rotamase) CYP8 FGSG_05403 Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum) TR39792_c2_g2_i3 P0C1I5 PPIL3_RHIO9 1.00E-44 GO:0003755; GO:0006457; GO:0000413 peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; Peptidyl-prolyl cis-trans isomerase-like 3 (PPIase) (EC 5.2.1.8) (Rotamase) cyp4 RO3G_06695 Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar) TR39792_c2_g2_i4 Q9H2H8 PPIL3_HUMAN 3.00E-54 GO:0071013; GO:0000398; GO:0003755; GO:0006457; GO:0000413 Q99152 "catalytic step 2 spliceosome; mRNA splicing, via spliceosome; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization" IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase-like 3 (PPIase) (EC 5.2.1.8) (Cyclophilin J) (CyPJ) (Cyclophilin-like protein PPIL3) (Rotamase PPIL3) PPIL3 Homo sapiens (Human) TR39792_c2_g4_i1 P0CP86 PPIL3_CRYNJ 6.00E-45 GO:0003755; GO:0006457; GO:0000413 peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase-like 3 (PPIase) (EC 5.2.1.8) (Rotamase) CYP10 CNE00680 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR39794_c1_g2_i1 Q54C67 CLCF_DICDI 8.00E-33 GO:0030554; GO:0034707; GO:0005247 adenyl nucleotide binding; chloride channel complex; voltage-gated chloride channel activity IPR000644; IPR014743; IPR001807; Chloride channel protein F clcF DDB_G0293130 Dictyostelium discoideum (Slime mold) TR39794_c1_g2_i4 Q5RDJ7 CLCN3_PONAB 1.00E-179 GO:0005524; GO:0005794; GO:0030165; GO:0015297; GO:0005769; GO:0031901; GO:0016021; GO:0005770; GO:0031902; GO:0030658; GO:0012506; GO:0005247 ATP binding; Golgi apparatus; PDZ domain binding; antiporter activity; early endosome; early endosome membrane; integral to membrane; late endosome; late endosome membrane; transport vesicle membrane; vesicle membrane; voltage-gated chloride channel activity IPR000644; IPR014743; IPR001807; IPR002245; H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3) CLCN3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39794_c1_g2_i5 P35525 CLCN2_RAT 2.00E-35 GO:0015629; GO:0030554; GO:0034707; GO:0030425; GO:0030324; GO:0043204; GO:0005247 actin cytoskeleton; adenyl nucleotide binding; chloride channel complex; dendrite; lung development; perikaryon; voltage-gated chloride channel activity IPR000644; IPR002244; IPR014743; IPR001807; Chloride channel protein 2 (ClC-2) Clcn2 Rattus norvegicus (Rat) TR39794_c1_g2_i6 P51791 CLCN3_MOUSE 9.00E-166 GO:0005524; GO:0005794; GO:0030165; GO:0015297; GO:0005769; GO:0031901; GO:0016021; GO:0031902; GO:0030658; GO:0012506; GO:0005247 ATP binding; Golgi apparatus; PDZ domain binding; antiporter activity; early endosome; early endosome membrane; integral to membrane; late endosome membrane; transport vesicle membrane; vesicle membrane; voltage-gated chloride channel activity IPR000644; IPR014743; IPR001807; IPR002245; H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3) Clcn3 Clc3 Mus musculus (Mouse) TR39795_c0_g2_i1 Q7TQK4 EXOS3_MOUSE 5.00E-80 GO:0071034; GO:0045006; GO:0003723; GO:0000177; GO:0004527; GO:0043928; GO:0000178; GO:0045190; GO:0000176; GO:0090305; GO:0005730; GO:0045830; GO:0006364; GO:0035327 CUT catabolic process; DNA deamination; RNA binding; cytoplasmic exosome (RNase complex); exonuclease activity; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; exosome (RNase complex); isotype switching; nuclear exosome (RNase complex); nucleic acid phosphodiester bond hydrolysis; nucleolus; positive regulation of isotype switching; rRNA processing; transcriptionally active chromatin IPR026699; IPR012340; Exosome complex component RRP40 (EC 3.1.13.-) (Exosome component 3) (Ribosomal RNA-processing protein 40) Exosc3 Rrp40 Mus musculus (Mouse) TR39795_c0_g2_i2 Q7KWX9 EXOS3_DICDI 1.00E-53 GO:0003723; GO:0005737; GO:0000178; GO:0005730; GO:0006364 RNA binding; cytoplasm; exosome (RNase complex); nucleolus; rRNA processing IPR026699; IPR012340; IPR022967; Putative exosome complex component rrp40 (Exosome component 3) (Ribosomal RNA-processing protein 40) exosc3 rrp40 DDB_G0276783 Dictyostelium discoideum (Slime mold) TR39796_c0_g2_i1 Q8WV93 LACE1_HUMAN 9.00E-147 GO:0005524; GO:0005739 ATP binding; mitochondrion IPR005654; IPR027417; Lactation elevated protein 1 (Protein AFG1 homolog) LACE1 AFG1 Homo sapiens (Human) TR39796_c0_g2_i4 P32317 AFG1_YEAST 3.00E-61 GO:0005524; GO:0034599; GO:0006515; GO:0005743; GO:0016558 ATP binding; cellular response to oxidative stress; misfolded or incompletely synthesized protein catabolic process; mitochondrial inner membrane; protein import into peroxisome matrix IPR005654; IPR027417; Protein AFG1 AFG1 AFG YEL052W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39797_c0_g1_i1 Q9Y285 SYFA_HUMAN 5.00E-35 GO:0005524; GO:0005829; GO:0004826; GO:0006432; GO:0006418; GO:0000049 Q9BQ95 ATP binding; cytosol; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA aminoacylation for protein translation; tRNA binding IPR006195; IPR004529; IPR002319; IPR011991; Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) FARSA FARS FARSL FARSLA Homo sapiens (Human) TR39797_c0_g1_i2 Q6AZG6 SYFAA_XENLA 0 GO:0005524; GO:0005737; GO:0004826; GO:0006432; GO:0000049 ATP binding; cytoplasm; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding IPR006195; IPR004529; IPR002319; Phenylalanine--tRNA ligase alpha subunit A (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit A) (PheRS) farsa-a farsla-a Xenopus laevis (African clawed frog) TR39797_c0_g1_i3 Q67QF3 SYFA_SYMTH 7.00E-35 GO:0005524; GO:0005737; GO:0000287; GO:0004826; GO:0006432; GO:0000049 ATP binding; cytoplasm; magnesium ion binding; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding IPR006195; IPR004529; IPR004188; IPR022911; IPR002319; IPR010978; Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) pheS pheSA STH1105 Symbiobacterium thermophilum (strain T / IAM 14863) TR39797_c0_g1_i4 Q1QS22 SYFA_NITHX 6.00E-35 GO:0005524; GO:0005737; GO:0000287; GO:0004826; GO:0006432; GO:0000049 ATP binding; cytoplasm; magnesium ion binding; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding IPR006195; IPR004529; IPR004188; IPR022911; IPR002319; IPR010978; Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) pheS Nham_0074 Nitrobacter hamburgensis (strain X14 / DSM 10229) TR39797_c0_g1_i5 Q1JPX3 SYFA_DANRE 0 GO:0005524; GO:0005737; GO:0004826; GO:0006432; GO:0000049 ATP binding; cytoplasm; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding IPR006195; IPR004529; IPR002319; IPR011991; Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) farsa farsla zgc:136506 zgc:158185 Danio rerio (Zebrafish) (Brachydanio rerio) TR39798_c3_g1_i1 P54358 DPOD1_DROME 6.00E-20 GO:0008296; GO:0051539; GO:0003677; GO:0006260; GO:0003887; GO:0043625; GO:0046872; GO:0005875; GO:0022008; GO:0000166; GO:0006974 "3'-5'-exodeoxyribonuclease activity; 4 iron, 4 sulfur cluster binding; DNA binding; DNA replication; DNA-directed DNA polymerase activity; delta DNA polymerase complex; metal ion binding; microtubule associated complex; neurogenesis; nucleotide binding; response to DNA damage stimulus" IPR006172; IPR017964; IPR006133; IPR006134; IPR004578; IPR023211; IPR012337; IPR025687; DNA polymerase delta catalytic subunit (EC 2.7.7.7) DNApol-delta POLD CG5949 Drosophila melanogaster (Fruit fly) TR39798_c4_g1_i1 O54747 DPOD1_RAT 0 GO:0008408; GO:0051539; GO:0003677; GO:0071897; GO:0045004; GO:0043137; GO:0003887; GO:0006287; GO:0043625; GO:0046872; GO:0000166; GO:0006297; GO:0007346 "3'-5' exonuclease activity; 4 iron, 4 sulfur cluster binding; DNA binding; DNA biosynthetic process; DNA replication proofreading; DNA replication, removal of RNA primer; DNA-directed DNA polymerase activity; base-excision repair, gap-filling; delta DNA polymerase complex; metal ion binding; nucleotide binding; nucleotide-excision repair, DNA gap filling; regulation of mitotic cell cycle" IPR006172; IPR017964; IPR006133; IPR006134; IPR004578; IPR023211; IPR012337; IPR025687; DNA polymerase delta catalytic subunit (EC 2.7.7.7) Pold1 Rattus norvegicus (Rat) TR39798_c5_g1_i1 Q9VGR2 MIDA_DROME 7.00E-115 GO:0032981; GO:0005739 Q9VML9 mitochondrial respiratory chain complex I assembly; mitochondrion IPR003788; "NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 homolog (Protein midA homolog, mitochondrial)" CG17726 Drosophila melanogaster (Fruit fly) TR39798_c5_g1_i2 Q7L592 MIDA_HUMAN 3.00E-136 GO:0008168; GO:0032981; GO:0005739 methyltransferase activity; mitochondrial respiratory chain complex I assembly; mitochondrion IPR003788; "NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 (Protein midA homolog, mitochondrial)" NDUFAF7 C2orf56 PRO1853 Homo sapiens (Human) TR39799_c0_g3_i3 Q00685 CO3_LAMJA 2.00E-53 GO:0006958; GO:0004866; GO:0005615; GO:0006954; GO:0045087; GO:0010951 "complement activation, classical pathway; endopeptidase inhibitor activity; extracellular space; inflammatory response; innate immune response; negative regulation of endopeptidase activity" IPR009048; IPR011626; IPR002890; IPR011625; IPR000020; IPR018081; IPR003344; IPR008964; IPR001599; IPR019742; IPR019565; IPR001134; IPR018933; IPR008930; IPR008993; Complement C3 [Cleaved into: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3 gamma chain] (Fragment) C3 Lampetra japonica (Japanese lamprey) (Entosphenus japonicus) TR39799_c0_g3_i4 Q8R422 CD109_MOUSE 5.00E-105 GO:0031225; GO:0005615; GO:0010951; GO:0005886; GO:0004867 anchored to membrane; extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; CD109 antigen (GPI-anchored alpha-2 macroglobulin-related protein) (CD antigen CD109) Cd109 Mus musculus (Mouse) TR39801_c1_g1_i1 Q99676 ZN184_HUMAN 2.00E-32 GO:0003677; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 184 ZNF184 Homo sapiens (Human) TR39801_c2_g1_i1 P83425 HIP_MYTED 9.00E-11 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR39802_c3_g1_i1 Q6DJC8 TM53B_XENLA 2.00E-41 GO:0016021 integral to membrane IPR008547; Transmembrane protein 53-B tmem53-b Xenopus laevis (African clawed frog) TR39802_c3_g1_i4 Q6DHN0 TMM53_DANRE 1.00E-40 GO:0016021 integral to membrane IPR008547; Transmembrane protein 53 tmem53 zgc:92204 Danio rerio (Zebrafish) (Brachydanio rerio) TR39804_c0_g1_i1 P07943 ALDR_RAT 6.00E-92 GO:0004032; GO:0005737; GO:0005615; GO:0046427; GO:0048661; GO:0010033; GO:0006061; GO:0031098 alditol:NADP+ 1-oxidoreductase activity; cytoplasm; extracellular space; positive regulation of JAK-STAT cascade; positive regulation of smooth muscle cell proliferation; response to organic substance; sorbitol biosynthetic process; stress-activated protein kinase signaling cascade IPR001395; IPR018170; IPR020471; IPR023210; Aldose reductase (AR) (EC 1.1.1.21) (Aldehyde reductase) Akr1b1 Akr1b4 Aldr1 Rattus norvegicus (Rat) TR39805_c0_g1_i2 Q9ULX7 CAH14_HUMAN 1.00E-51 GO:0015701; GO:0004089; GO:0016021; GO:0046872; GO:0005886; GO:0044281 bicarbonate transport; carbonate dehydratase activity; integral to membrane; metal ion binding; plasma membrane; small molecule metabolic process IPR018429; IPR001148; IPR023561; Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV) CA14 UNQ690/PRO1335 Homo sapiens (Human) TR39805_c0_g1_i4 Q20781 CAH1_CAEEL 9.00E-16 GO:0004089; GO:0005576; GO:0008270 carbonate dehydratase activity; extracellular region; zinc ion binding IPR001148; IPR023561; IPR018347; Putative carbonic anhydrase-like protein 1 cah-1 F54D8.4 Caenorhabditis elegans TR39806_c1_g1_i2 Q9NRA2 S17A5_HUMAN 4.00E-134 GO:0006865; GO:0030054; GO:0005887; GO:0005765; GO:0015136; GO:0015739; GO:0005351; GO:0030672 amino acid transport; cell junction; integral to plasma membrane; lysosomal membrane; sialic acid transmembrane transporter activity; sialic acid transport; sugar:hydrogen symporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) TR39806_c1_g1_i4 Q9NRA2 S17A5_HUMAN 8.00E-135 GO:0006865; GO:0030054; GO:0005887; GO:0005765; GO:0015136; GO:0015739; GO:0005351; GO:0030672 amino acid transport; cell junction; integral to plasma membrane; lysosomal membrane; sialic acid transmembrane transporter activity; sialic acid transport; sugar:hydrogen symporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) TR39806_c1_g1_i7 Q9MZD1 S17A5_SHEEP 2.00E-131 GO:0016021; GO:0005765; GO:0015293 integral to membrane; lysosomal membrane; symporter activity IPR011701; IPR020846; IPR016196; Sialin (Membrane glycoprotein SP55) (Sodium/sialic acid cotransporter) (Solute carrier family 17 member 5) SLC17A5 Ovis aries (Sheep) TR39808_c6_g1_i8 Q5SVZ6 ZMYM1_HUMAN 9.00E-07 GO:0003676; GO:0005634; GO:0008270 nucleic acid binding; nucleus; zinc ion binding IPR025398; IPR008906; IPR012337; IPR011017; IPR010507; IPR006580; Zinc finger MYM-type protein 1 ZMYM1 Homo sapiens (Human) TR39809_c1_g4_i1 Q6DHQ1 HVCN1_DANRE 2.00E-23 GO:0016021; GO:0005244 integral to membrane; voltage-gated ion channel activity IPR027359; IPR005821; Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) hvcn1 zgc:92181 Danio rerio (Zebrafish) (Brachydanio rerio) TR39809_c1_g4_i3 Q96D96 HVCN1_HUMAN 2.00E-22 GO:0016021; GO:0032504; GO:0005886; GO:0009268; GO:0010043; GO:0035036; GO:0030171 integral to membrane; multicellular organism reproduction; plasma membrane; response to pH; response to zinc ion; sperm-egg recognition; voltage-gated proton channel activity IPR027359; IPR005821; Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) (Voltage sensor domain-only protein) HVCN1 VSOP UNQ578/PRO1140 Homo sapiens (Human) TR39811_c0_g1_i1 Q8BRT1 CLAP2_MOUSE 1.00E-42 GO:0005794; GO:0051301; GO:0016477; GO:0000777; GO:0005881; GO:0007163; GO:0007126; GO:0034453; GO:0007020; GO:0005815; GO:0031023; GO:0051010; GO:0007067; GO:0007026; GO:0032587; GO:0000922; GO:0005802 Golgi apparatus; cell division; cell migration; condensed chromosome kinetochore; cytoplasmic microtubule; establishment or maintenance of cell polarity; meiosis; microtubule anchoring; microtubule nucleation; microtubule organizing center; microtubule organizing center organization; microtubule plus-end binding; mitosis; negative regulation of microtubule depolymerization; ruffle membrane; spindle pole; trans-Golgi network IPR011989; IPR016024; IPR024395; CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) Clasp2 Kiaa0627 Mus musculus (Mouse) TR39811_c0_g1_i2 Q4U0G1 CLA1A_XENLA 8.00E-113 GO:0005794; GO:0051301; GO:0000777; GO:0005874; GO:0034453; GO:0007020; GO:0005815; GO:0031023; GO:0007067; GO:0005819 Golgi apparatus; cell division; condensed chromosome kinetochore; microtubule; microtubule anchoring; microtubule nucleation; microtubule organizing center; microtubule organizing center organization; mitosis; spindle IPR011989; IPR016024; IPR024395; IPR021133; CLIP-associating protein 1-A (Cytoplasmic linker-associated protein 1-A) (XCLASP1) clasp1-a clasp Xenopus laevis (African clawed frog) TR39811_c0_g2_i2 Q99JD4 CLAP2_RAT 0 GO:0005794; GO:0051301; GO:0000777; GO:0005874; GO:0034453; GO:0007020; GO:0005815; GO:0031023; GO:0051010; GO:0007067; GO:0007026; GO:0032587; GO:0005819; GO:0005802 Golgi apparatus; cell division; condensed chromosome kinetochore; microtubule; microtubule anchoring; microtubule nucleation; microtubule organizing center; microtubule organizing center organization; microtubule plus-end binding; mitosis; negative regulation of microtubule depolymerization; ruffle membrane; spindle; trans-Golgi network IPR011989; IPR016024; IPR024395; CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) Clasp2 Rattus norvegicus (Rat) TR39813_c4_g1_i2 Q95SX7 RTBS_DROME 2.00E-18 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR39814_c1_g1_i1 Q8K0U4 HS12A_MOUSE 1.00E-44 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR39814_c1_g1_i3 A7ZEB5 DNAK_CAMC1 8.00E-09 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK Ccon26_12700 CCC13826_2046 Campylobacter concisus (strain 13826) TR39814_c1_g1_i4 Q9CZJ2 HS12B_MOUSE 5.00E-62 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR39816_c0_g1_i1 Q91641 THIB_XENLA 6.00E-10 GO:0005615; GO:0016020; GO:0007275 extracellular space; membrane; multicellular organismal development IPR008985; IPR000998; Thyroid hormone-induced protein B Xenopus laevis (African clawed frog) TR39816_c3_g2_i1 P42674 BP10_PARLI 6.00E-30 GO:0005938; GO:0005615; GO:0004222; GO:0048471; GO:0006508; GO:0008270 cell cortex; extracellular space; metalloendopeptidase activity; perinuclear region of cytoplasm; proteolysis; zinc ion binding IPR000859; IPR000742; IPR013032; IPR024079; IPR001506; IPR006026; IPR017369; Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) TR39816_c3_g3_i1 P98073 ENTK_HUMAN 5.00E-06 GO:0005903; GO:0016021; GO:0006508; GO:0005044; GO:0004252 brush border; integral to membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity IPR008985; IPR000859; IPR023415; IPR002172; IPR000998; IPR001254; IPR018114; IPR001314; IPR000082; IPR001190; IPR017448; IPR009003; Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain] TMPRSS15 ENTK PRSS7 Homo sapiens (Human) TR39816_c3_g3_i2 Q18206 NAS36_CAEEL 2.00E-32 GO:0005576; GO:0004222; GO:0018996; GO:0007275; GO:0006508; GO:0008270 "extracellular region; metalloendopeptidase activity; molting cycle, collagen and cuticulin-based cuticle; multicellular organismal development; proteolysis; zinc ion binding" IPR000859; IPR024079; IPR001506; IPR017050; IPR006026; IPR000884; Zinc metalloproteinase nas-36 (EC 3.4.24.21) (Nematode astacin 36) nas-36 C26C6.3 Caenorhabditis elegans TR39816_c3_g3_i3 Q20942 NAS38_CAEEL 7.00E-30 GO:0005576; GO:0004222; GO:0006508; GO:0008270 extracellular region; metalloendopeptidase activity; proteolysis; zinc ion binding IPR000859; IPR024079; IPR001506; IPR006026; IPR000884; Zinc metalloproteinase nas-38 (EC 3.4.24.21) (Nematode astacin 38) nas-38 F57C12.1 Caenorhabditis elegans TR39816_c3_g3_i4 P98068 SPAN_STRPU 3.00E-47 GO:0004222; GO:0007275; GO:0006508; GO:0008270 metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR000859; IPR000742; IPR013032; IPR024079; IPR001506; IPR006026; IPR017369; Protein SpAN (EC 3.4.24.-) SPAN Strongylocentrotus purpuratus (Purple sea urchin) TR39816_c3_g4_i1 Q0PMG2 MDGA1_MOUSE 8.00E-14 GO:0046658; GO:0021799; GO:0001764 anchored to plasma membrane; cerebral cortex radially oriented cell migration; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 Mdga1 Mus musculus (Mouse) TR39816_c3_g4_i2 Q63191 AEGP_RAT 3.00E-06 GO:0005768; GO:0016021; GO:0015031 endosome; integral to membrane; protein transport IPR008985; IPR023415; IPR002172; IPR000998; Apical endosomal glycoprotein (MAM domain-containing protein 4) Mamdc4 Aegp Rattus norvegicus (Rat) TR39816_c3_g4_i3 Q9GMT4 MDGA2_MACFA 2.00E-15 GO:0031225; GO:0005886 anchored to membrane; plasma membrane IPR008985; IPR003961; IPR007110; IPR013783; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 2 (MAM domain-containing protein 1) (Fragment) MDGA2 MAMDC1 QccE-16296 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR39817_c1_g1_i1 Q0VA04 SMG8_XENTR 2.00E-59 GO:0000184; GO:0045859 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; regulation of protein kinase activity" IPR019354; Protein smg8 (Protein smg-8 homolog) smg8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39817_c1_g3_i1 Q8VE18 SMG8_MOUSE 4.00E-54 GO:0000184; GO:0045859 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; regulation of protein kinase activity" IPR019354; Protein SMG8 (Protein smg-8 homolog) Smg8 Mus musculus (Mouse) TR39817_c1_g3_i2 B0W730 SMG8_CULQU 6.00E-58 GO:0000184 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" IPR019354; Protein SMG8 (Protein smg-8 homolog) CPIJ003128 Culex quinquefasciatus (Southern house mosquito) (Culex pungens) TR39817_c1_g3_i3 B0W730 SMG8_CULQU 1.00E-57 GO:0000184 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" IPR019354; Protein SMG8 (Protein smg-8 homolog) CPIJ003128 Culex quinquefasciatus (Southern house mosquito) (Culex pungens) TR39818_c2_g1_i1 P13596 NCAM1_RAT 2.00E-06 GO:0007568; GO:0016338; GO:0071241; GO:0008092; GO:0005104; GO:0030426; GO:0008201; GO:0016021; GO:0007611; GO:0033555; GO:0060548; GO:0043025; GO:0031100; GO:0014012; GO:0019902; GO:0005886; GO:0060045; GO:0051930; GO:0042220; GO:0014076; GO:0010288; GO:0021794 P16092; Q63237 aging; calcium-independent cell-cell adhesion; cellular response to inorganic substance; cytoskeletal protein binding; fibroblast growth factor receptor binding; growth cone; heparin binding; integral to membrane; learning or memory; multicellular organismal response to stress; negative regulation of cell death; neuronal cell body; organ regeneration; peripheral nervous system axon regeneration; phosphatase binding; plasma membrane; positive regulation of cardiac muscle cell proliferation; regulation of sensory perception of pain; response to cocaine; response to fluoxetine; response to lead ion; thalamus development IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR009138; Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56) Ncam1 Ncam Rattus norvegicus (Rat) TR39818_c5_g5_i1 P18286 IPNS_STRJU 5.00E-17 GO:0031418; GO:0017000; GO:0005506; GO:0016216; GO:0016706 "L-ascorbic acid binding; antibiotic biosynthetic process; iron ion binding; isopenicillin-N synthase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" IPR026992; IPR027443; IPR002057; IPR002283; IPR005123; Antibiotic biosynthesis; penicillin G biosynthesis; penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 2/3. Isopenicillin N synthase (IPNS) (EC 1.21.3.1) pcbC Streptomyces jumonjinensis TR39819_c2_g4_i1 Q80TA1 EPT1_MOUSE 3.00E-58 GO:0004307; GO:0016021; GO:0046872; GO:0006646 ethanolaminephosphotransferase activity; integral to membrane; metal ion binding; phosphatidylethanolamine biosynthetic process IPR000462; IPR014472; Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3. Ethanolaminephosphotransferase 1 (EC 2.7.8.1) (Selenoprotein I) (SelI) Ept1 D5Wsu178e Kiaa1724 Seli Mus musculus (Mouse) TR39820_c0_g1_i2 A9BE39 LEPA_PROM4 6.00E-06 GO:0005525; GO:0006184; GO:0003924; GO:0005886; GO:0045727; GO:0043022; GO:0003746; GO:0006414 GTP binding; GTP catabolic process; GTPase activity; plasma membrane; positive regulation of translation; ribosome binding; translation elongation factor activity; translational elongation IPR006297; IPR000795; IPR009022; IPR000640; IPR027518; IPR013842; IPR027417; IPR005225; IPR009000; IPR004161; Elongation factor 4 (EF-4) (EC 3.6.5.n1) (Ribosomal back-translocase LepA) lepA P9211_04181 Prochlorococcus marinus (strain MIT 9211) TR39820_c0_g2_i1 P57772 SELB_HUMAN 0 GO:0005525; GO:0003924; GO:0005737; GO:0005739; GO:0005634; GO:0001514; GO:0000049; GO:0003746 GTP binding; GTPase activity; cytoplasm; mitochondrion; nucleus; selenocysteine incorporation; tRNA binding; translation elongation factor activity IPR000795; IPR027417; IPR009000; IPR004161; "Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific)" EEFSEC SELB Homo sapiens (Human) TR39820_c0_g2_i3 P57772 SELB_HUMAN 0 GO:0005525; GO:0003924; GO:0005737; GO:0005739; GO:0005634; GO:0001514; GO:0000049; GO:0003746 GTP binding; GTPase activity; cytoplasm; mitochondrion; nucleus; selenocysteine incorporation; tRNA binding; translation elongation factor activity IPR000795; IPR027417; IPR009000; IPR004161; "Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific)" EEFSEC SELB Homo sapiens (Human) TR39821_c3_g3_i2 P49300 CLC10_MOUSE 1.00E-14 GO:0030246; GO:0016021 carbohydrate binding; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR005640; C-type lectin domain family 10 member A (MMGL) (Macrophage asialoglycoprotein-binding protein 1) (M-ASGP-BP-1) (Macrophage galactose/N-acetylgalactosamine-specific lectin) Clec10a Mgl Mgl1 Mus musculus (Mouse) TR39821_c3_g3_i3 Q61830 MRC1_MOUSE 7.00E-11 GO:0009986; GO:0010008; GO:0016021; GO:0005537; GO:0005886; GO:0006898; GO:0004888 cell surface; endosome membrane; integral to membrane; mannose binding; plasma membrane; receptor-mediated endocytosis; transmembrane signaling receptor activity IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; Macrophage mannose receptor 1 (MMR) (CD antigen CD206) Mrc1 Mus musculus (Mouse) TR39821_c3_g3_i4 P82596 PLC_HALLA 1.00E-20 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR39821_c3_g3_i6 P86854 PLCL_MYTGA 3.00E-27 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR39821_c3_g3_i7 Q4V885 COL12_RAT 4.00E-18 GO:0030246; GO:0005581; GO:0006955; GO:0016021; GO:0030169; GO:0046872; GO:0006910; GO:0008329 "carbohydrate binding; collagen; immune response; integral to membrane; low-density lipoprotein particle binding; metal ion binding; phagocytosis, recognition; signaling pattern recognition receptor activity" IPR001304; IPR016186; IPR018378; IPR016187; IPR008160; Collectin-12 (Collectin placenta protein 1) (CL-P1) (Nurse cell scavenger receptor 2) Colec12 Clp1 Nsr2 Rattus norvegicus (Rat) TR39821_c3_g3_i8 Q9Z2H6 CLC4D_MOUSE 6.00E-11 GO:0030246; GO:0045087; GO:0016021 carbohydrate binding; innate immune response; integral to membrane IPR001304; IPR016186; IPR016187; C-type lectin domain family 4 member D (C-type lectin superfamily member 8) (Macrophage-restricted C-type lectin) Clec4d Clecsf8 Mcl Mus musculus (Mouse) TR39821_c3_g3_i9 P86854 PLCL_MYTGA 3.00E-25 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR39823_c2_g1_i2 Q9JJP2 P73_MOUSE 2.00E-83 GO:0006978; GO:0007050; GO:0034644; GO:0033326; GO:0000785; GO:0003682; GO:0005829; GO:0003684; GO:0048546; GO:0003690; GO:0021766; GO:0006954; GO:0042771; GO:0046872; GO:0031571; GO:0043508; GO:0043524; GO:0000122; GO:0048666; GO:0005634; GO:0045793; GO:1902167; GO:0045944; GO:0009791; GO:0051262; GO:0001836; GO:0010165; GO:0010332; GO:0043565; GO:0003700; GO:0005667; GO:0044212; GO:0006351 P46938 "DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; cell cycle arrest; cellular response to UV; cerebrospinal fluid secretion; chromatin; chromatin binding; cytosol; damaged DNA binding; digestive tract morphogenesis; double-stranded DNA binding; hippocampus development; inflammatory response; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; metal ion binding; mitotic G1 DNA damage checkpoint; negative regulation of JUN kinase activity; negative regulation of neuron apoptotic process; negative regulation of transcription from RNA polymerase II promoter; neuron development; nucleus; positive regulation of cell size; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of transcription from RNA polymerase II promoter; post-embryonic development; protein tetramerization; release of cytochrome c from mitochondria; response to X-ray; response to gamma radiation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR008967; IPR012346; IPR011615; IPR010991; IPR002117; IPR001660; IPR013761; IPR011510; Tumor protein p73 (p53-like transcription factor) (p53-related protein) Tp73 P73 Trp73 Mus musculus (Mouse) TR39823_c2_g1_i3 Q9XSK8 P73_CHLAE 2.00E-93 GO:0006915; GO:0007049; GO:0005737; GO:0046872; GO:0005634; GO:0051262; GO:0003700; GO:0044212; GO:0006351 "apoptotic process; cell cycle; cytoplasm; metal ion binding; nucleus; protein tetramerization; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR008967; IPR012346; IPR011615; IPR010991; IPR002117; IPR001660; IPR013761; IPR011510; Tumor protein p73 (p53-like transcription factor) (p53-related protein) TP73 P73 Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) TR39823_c2_g1_i4 Q9H3D4 P63_HUMAN 3.00E-92 GO:0006978; GO:0005794; GO:0007219; GO:0001077; GO:0007569; GO:0034644; GO:0003682; GO:0006338; GO:0060197; GO:0005829; GO:0003684; GO:0030425; GO:0003690; GO:0007499; GO:0030326; GO:0010481; GO:0002064; GO:0001736; GO:0048807; GO:0031069; GO:0042771; GO:0030216; GO:0043616; GO:0046872; GO:0031571; GO:0010259; GO:0043066; GO:0045617; GO:2000381; GO:0000122; GO:0051402; GO:0000790; GO:0005654; GO:0042475; GO:0002039; GO:0030859; GO:0045747; GO:2000271; GO:0002053; GO:0045669; GO:0045944; GO:0036342; GO:0060513; GO:0051289; GO:0009954; GO:0043523; GO:0010165; GO:0010332; GO:0043565; GO:0003700; GO:0001501; GO:0048745; GO:0060529; GO:0048485; GO:0005667; GO:0044212; GO:0060157 Q8TDN4; P35637; P61978; Q9UFN0; Q9UPW6; Q15796; P04637 "DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; Golgi apparatus; Notch signaling pathway; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; cell aging; cellular response to UV; chromatin binding; chromatin remodeling; cloacal septation; cytosol; damaged DNA binding; dendrite; double-stranded DNA binding; ectoderm and mesoderm interaction; embryonic limb morphogenesis; epidermal cell division; epithelial cell development; establishment of planar polarity; female genitalia morphogenesis; hair follicle morphogenesis; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; keratinocyte differentiation; keratinocyte proliferation; metal ion binding; mitotic G1 DNA damage checkpoint; multicellular organismal aging; negative regulation of apoptotic process; negative regulation of keratinocyte differentiation; negative regulation of mesoderm development; negative regulation of transcription from RNA polymerase II promoter; neuron apoptotic process; nuclear chromatin; nucleoplasm; odontogenesis of dentin-containing tooth; p53 binding; polarized epithelial cell differentiation; positive regulation of Notch signaling pathway; positive regulation of fibroblast apoptotic process; positive regulation of mesenchymal cell proliferation; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; post-anal tail morphogenesis; prostatic bud formation; protein homotetramerization; proximal/distal pattern formation; regulation of neuron apoptotic process; response to X-ray; response to gamma radiation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; skeletal system development; smooth muscle tissue development; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; sympathetic nervous system development; transcription factor complex; transcription regulatory region DNA binding; urinary bladder development" IPR008967; IPR012346; IPR011615; IPR010991; IPR002117; IPR001660; IPR013761; IPR011510; Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51) TP63 KET P63 P73H P73L TP73L Homo sapiens (Human) TR39826_c0_g1_i2 P66946 ILVG_MYCTU 9.00E-51 GO:0003984; GO:0009097; GO:0000287; GO:0030976; GO:0009099 acetolactate synthase activity; isoleucine biosynthetic process; magnesium ion binding; thiamine pyrophosphate binding; valine biosynthetic process IPR012000; IPR012001; IPR000399; IPR011766; Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4. Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4. Acetolactate synthase large subunit IlvG (ALS) (EC 2.2.1.6) (Acetohydroxy-acid synthase large subunit) (AHAS) ilvG Rv1820 MT1868 MTCY1A11.23c Mycobacterium tuberculosis TR39826_c0_g1_i3 Q6NV04 ILVBL_DANRE 5.00E-156 GO:0016021; GO:0000287; GO:0008152; GO:0030976; GO:0016740 integral to membrane; magnesium ion binding; metabolic process; thiamine pyrophosphate binding; transferase activity IPR012000; IPR012001; IPR000399; IPR011766; Acetolactate synthase-like protein (EC 2.2.1.-) (IlvB-like protein) ilvbl zgc:66376 zgc:85697 Danio rerio (Zebrafish) (Brachydanio rerio) TR39827_c0_g1_i1 O22252 MHX_ARATH 6.00E-33 GO:0016021; GO:0006826; GO:0015693; GO:0055085; GO:0005774; GO:0006829 integral to membrane; iron ion transport; magnesium ion transport; transmembrane transport; vacuolar membrane; zinc ion transport IPR004837; Magnesium/proton exchanger (Mg(2+)/H(+) exchanger) (AtMHX) (Zinc/proton exchanger) (Zn(2+)/H(+) exchanger) MHX MHX1 At2g47600 T30B22.10 Arabidopsis thaliana (Mouse-ear cress) TR39827_c0_g1_i2 P70549 NAC3_RAT 2.00E-85 GO:1990034; GO:1990035; GO:0060402; GO:0005432; GO:0007154; GO:0071320; GO:0043197; GO:0016021; GO:0005874; GO:0005739; GO:0043025; GO:0042383; GO:0021537 calcium ion export from cell; calcium ion import into cell; calcium ion transport into cytosol; calcium:sodium antiporter activity; cell communication; cellular response to cAMP; dendritic spine; integral to membrane; microtubule; mitochondrion; neuronal cell body; sarcolemma; telencephalon development IPR003644; IPR004836; IPR004837; Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) Slc8a3 Ncx3 Rattus norvegicus (Rat) TR39828_c0_g2_i1 Q9BSE5 SPEB_HUMAN 8.00E-74 GO:0008783; GO:0097055; GO:0046872; GO:0005739; GO:0006595; GO:0033388; GO:0044281; GO:0008295 agmatinase activity; agmatine biosynthetic process; metal ion binding; mitochondrion; polyamine metabolic process; putrescine biosynthetic process from arginine; small molecule metabolic process; spermidine biosynthetic process IPR005925; IPR006035; IPR023696; IPR020855; Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1. "Agmatinase, mitochondrial (EC 3.5.3.11) (Agmatine ureohydrolase) (AUH)" AGMAT Homo sapiens (Human) TR39828_c0_g2_i2 Q90XD2 SPEB_CHICK 3.00E-79 GO:0008783; GO:0046872; GO:0005739; GO:0033388; GO:0008295 agmatinase activity; metal ion binding; mitochondrion; putrescine biosynthetic process from arginine; spermidine biosynthetic process IPR005925; IPR006035; IPR023696; IPR020855; Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1. "Agmatinase, mitochondrial (EC 3.5.3.11) (Agmatine ureohydrolase) (AUH)" AGMAT Gallus gallus (Chicken) TR39828_c0_g3_i1 Q9HQD7 HUTG_HALSA 8.00E-07 GO:0050415; GO:0019556; GO:0019557; GO:0030145 formimidoylglutamase activity; histidine catabolic process to glutamate and formamide; histidine catabolic process to glutamate and formate; manganese ion binding IPR005923; IPR006035; IPR023696; Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (hydrolase route): step 1/1. Probable formimidoylglutamase (EC 3.5.3.8) (Formiminoglutamase) (Formiminoglutamate hydrolase) hutG VNG_1209G Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) TR39828_c0_g3_i2 P73270 SPEB2_SYNY3 2.00E-18 GO:0008783; GO:0046872; GO:0009446 agmatinase activity; metal ion binding; putrescine biosynthetic process IPR005925; IPR006035; IPR023696; IPR020855; Probable agmatinase 2 (EC 3.5.3.11) (Agmatine ureohydrolase 2) (AUH 2) speB2 sll1077 Synechocystis sp. (strain PCC 6803 / Kazusa) TR39829_c2_g1_i1 Q9FMU5 UTP18_ARATH 3.00E-89 GO:0080008; GO:0005730; GO:0006364 Cul4-RING ubiquitin ligase complex; nucleolus; rRNA processing IPR015943; IPR001680; IPR019775; IPR017986; U3 small nucleolar RNA-associated protein 18 homolog At5g14050 MUA22.5 Arabidopsis thaliana (Mouse-ear cress) TR39829_c2_g1_i2 Q5SSI6 UTP18_MOUSE 3.00E-114 GO:0005730; GO:0006364 nucleolus; rRNA processing IPR015943; IPR001680; IPR017986; U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50) Utp18 Wdr50 Mus musculus (Mouse) TR39829_c2_g1_i4 Q5SSI6 UTP18_MOUSE 4.00E-117 GO:0005730; GO:0006364 nucleolus; rRNA processing IPR015943; IPR001680; IPR017986; U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50) Utp18 Wdr50 Mus musculus (Mouse) TR39829_c2_g1_i5 Q8YRI1 YY46_NOSS1 2.00E-08 GO:0006355 "regulation of transcription, DNA-dependent" IPR001646; IPR020472; IPR007111; IPR027417; IPR011047; IPR027728; IPR015943; IPR001680; IPR019775; IPR017986; Uncharacterized WD repeat-containing protein alr3466 alr3466 Nostoc sp. (strain PCC 7120 / UTEX 2576) TR39830_c2_g1_i1 P49020 TMED2_CRIGR 4.00E-105 GO:0030137; GO:0030663; GO:0032580; GO:0007030; GO:0005783; GO:0005789; GO:0005793; GO:0033116; GO:0016021; GO:0034260; GO:0072661; GO:0016192 COPI-coated vesicle; COPI-coated vesicle membrane; Golgi cisterna membrane; Golgi organization; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; negative regulation of GTPase activity; protein targeting to plasma membrane; vesicle-mediated transport IPR009038; Transmembrane emp24 domain-containing protein 2 (COPI-coated vesicle membrane protein p24) (p24 family protein beta-1) (p24beta1) (Fragment) TMED2 RNP24 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR39831_c3_g1_i1 Q9D7H3 RTCA_MOUSE 7.00E-14 GO:0005524; GO:0006396; GO:0003963; GO:0005654 ATP binding; RNA processing; RNA-3'-phosphate cyclase activity; nucleoplasm IPR013791; IPR023797; IPR000228; IPR017770; IPR020719; IPR013792; RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) (RNA terminal phosphate cyclase domain-containing protein 1) RtcA Rpc1 Rtcd1 Mus musculus (Mouse) TR39831_c3_g3_i2 O77264 RTCA_DROME 3.00E-58 GO:0005524; GO:0006396; GO:0003963; GO:0005654 ATP binding; RNA processing; RNA-3'-phosphate cyclase activity; nucleoplasm IPR013791; IPR023797; IPR000228; IPR017770; IPR013792; RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) CG4061 Drosophila melanogaster (Fruit fly) TR39831_c3_g3_i3 A8MAV7 RTCA_CALMQ 1.00E-43 GO:0005524; GO:0006396; GO:0003963; GO:0005737 ATP binding; RNA processing; RNA-3'-phosphate cyclase activity; cytoplasm IPR013791; IPR023797; IPR000228; IPR017770; IPR020719; IPR013792; RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) rtcA Cmaq_0295 Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167) TR39831_c3_g3_i4 Q9D7H3 RTCA_MOUSE 3.00E-106 GO:0005524; GO:0006396; GO:0003963; GO:0005654 ATP binding; RNA processing; RNA-3'-phosphate cyclase activity; nucleoplasm IPR013791; IPR023797; IPR000228; IPR017770; IPR020719; IPR013792; RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) (RNA terminal phosphate cyclase domain-containing protein 1) RtcA Rpc1 Rtcd1 Mus musculus (Mouse) TR39832_c0_g1_i1 Q6PQZ1 AQP1_PIG 1.00E-55 GO:0051739; GO:0015696; GO:0016324; GO:0009925; GO:0031526; GO:0006182; GO:0035379; GO:0006884; GO:0071474; GO:0034644; GO:0071320; GO:0071280; GO:0071549; GO:0070301; GO:0071456; GO:0071260; GO:0071288; GO:0071300; GO:0071472; GO:0005737; GO:0030950; GO:0015168; GO:0016021; GO:0005223; GO:0021670; GO:0085018; GO:0043066; GO:0030184; GO:0031965; GO:0045766; GO:0048146; GO:0046878; GO:0005267; GO:0003097; GO:0042493; GO:0042383; GO:0035377; GO:0015250 ammonia transmembrane transporter activity; ammonium transport; apical plasma membrane; basal plasma membrane; brush border membrane; cGMP biosynthetic process; carbon dioxide transmembrane transporter activity; cell volume homeostasis; cellular hyperosmotic response; cellular response to UV; cellular response to cAMP; cellular response to copper ion; cellular response to dexamethasone stimulus; cellular response to hydrogen peroxide; cellular response to hypoxia; cellular response to mechanical stimulus; cellular response to mercury ion; cellular response to retinoic acid; cellular response to salt stress; cytoplasm; establishment or maintenance of actin cytoskeleton polarity; glycerol transmembrane transporter activity; integral to membrane; intracellular cGMP activated cation channel activity; lateral ventricle development; maintenance of symbiont-containing vacuole by host; negative regulation of apoptotic process; nitric oxide transmembrane transporter activity; nuclear membrane; positive regulation of angiogenesis; positive regulation of fibroblast proliferation; positive regulation of saliva secretion; potassium channel activity; renal water transport; response to drug; sarcolemma; transepithelial water transport; water channel activity IPR023271; IPR023274; IPR000425; IPR022357; Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Water channel protein for red blood cells and kidney proximal tubule) AQP1 Sus scrofa (Pig) TR39832_c0_g1_i2 P55088 AQP4_MOUSE 1.00E-48 GO:0030315; GO:0016323; GO:0015670; GO:0005911; GO:0071392; GO:0071346; GO:0005737; GO:0009897; GO:0007565; GO:0042538; GO:0005887; GO:0015288; GO:0043234; GO:0051260; GO:0070295; GO:0051384; GO:0009314; GO:0007605; GO:0015250 T-tubule; basolateral plasma membrane; carbon dioxide transport; cell-cell junction; cellular response to estradiol stimulus; cellular response to interferon-gamma; cytoplasm; external side of plasma membrane; female pregnancy; hyperosmotic salinity response; integral to plasma membrane; porin activity; protein complex; protein homooligomerization; renal water absorption; response to glucocorticoid stimulus; response to radiation; sensory perception of sound; water channel activity IPR023271; IPR000425; IPR022357; Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4) Aqp4 Mus musculus (Mouse) TR39832_c0_g1_i4 Q6PQZ1 AQP1_PIG 1.00E-55 GO:0051739; GO:0015696; GO:0016324; GO:0009925; GO:0031526; GO:0006182; GO:0035379; GO:0006884; GO:0071474; GO:0034644; GO:0071320; GO:0071280; GO:0071549; GO:0070301; GO:0071456; GO:0071260; GO:0071288; GO:0071300; GO:0071472; GO:0005737; GO:0030950; GO:0015168; GO:0016021; GO:0005223; GO:0021670; GO:0085018; GO:0043066; GO:0030184; GO:0031965; GO:0045766; GO:0048146; GO:0046878; GO:0005267; GO:0003097; GO:0042493; GO:0042383; GO:0035377; GO:0015250 ammonia transmembrane transporter activity; ammonium transport; apical plasma membrane; basal plasma membrane; brush border membrane; cGMP biosynthetic process; carbon dioxide transmembrane transporter activity; cell volume homeostasis; cellular hyperosmotic response; cellular response to UV; cellular response to cAMP; cellular response to copper ion; cellular response to dexamethasone stimulus; cellular response to hydrogen peroxide; cellular response to hypoxia; cellular response to mechanical stimulus; cellular response to mercury ion; cellular response to retinoic acid; cellular response to salt stress; cytoplasm; establishment or maintenance of actin cytoskeleton polarity; glycerol transmembrane transporter activity; integral to membrane; intracellular cGMP activated cation channel activity; lateral ventricle development; maintenance of symbiont-containing vacuole by host; negative regulation of apoptotic process; nitric oxide transmembrane transporter activity; nuclear membrane; positive regulation of angiogenesis; positive regulation of fibroblast proliferation; positive regulation of saliva secretion; potassium channel activity; renal water transport; response to drug; sarcolemma; transepithelial water transport; water channel activity IPR023271; IPR023274; IPR000425; IPR022357; Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Water channel protein for red blood cells and kidney proximal tubule) AQP1 Sus scrofa (Pig) TR39832_c0_g1_i6 P0CD98 YLL53_YEAST 6.00E-12 GO:0016021; GO:0005215 integral to membrane; transporter activity IPR023271; IPR000425; Putative uncharacterized protein YLL053C YLL053C L0587 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39833_c0_g2_i2 Q6NTV6 INF2_XENLA 2.00E-67 GO:0030036 actin cytoskeleton organization IPR016024; IPR015425; IPR010472; IPR010473; IPR014768; IPR003124; Inverted formin-2 inf2 Xenopus laevis (African clawed frog) TR39833_c0_g2_i3 Q6NTV6 INF2_XENLA 5.00E-74 GO:0030036 actin cytoskeleton organization IPR016024; IPR015425; IPR010472; IPR010473; IPR014768; IPR003124; Inverted formin-2 inf2 Xenopus laevis (African clawed frog) TR39834_c0_g2_i1 Q9BUN8 DERL1_HUMAN 2.00E-105 GO:0030433; GO:0042288; GO:0005769; GO:0030968; GO:0030176; GO:0019060; GO:0005770; GO:0004872; GO:0030970 P51572; P13569 "ER-associated protein catabolic process; MHC class I protein binding; early endosome; endoplasmic reticulum unfolded protein response; integral to endoplasmic reticulum membrane; intracellular transport of viral proteins in host cell; late endosome; receptor activity; retrograde protein transport, ER to cytosol" IPR007599; Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1) DERL1 DER1 UNQ243/PRO276 Homo sapiens (Human) TR39835_c0_g1_i1 P38127 RIM2_YEAST 2.00E-48 GO:0016021; GO:0000002; GO:0005743; GO:0005739; GO:0015218 integral to membrane; mitochondrial genome maintenance; mitochondrial inner membrane; mitochondrion; pyrimidine nucleotide transmembrane transporter activity IPR002067; IPR018108; IPR023395; Mitochondrial carrier protein RIM2 RIM2 YBR192W YBR1402 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39835_c0_g1_i3 Q96CQ1 S2536_HUMAN 9.00E-104 GO:0016021; GO:0005743; GO:0032355; GO:0055085 integral to membrane; mitochondrial inner membrane; response to estradiol stimulus; transmembrane transport IPR002067; IPR018108; IPR023395; Solute carrier family 25 member 36 SLC25A36 Homo sapiens (Human) TR39836_c0_g1_i1 G5EBU4 ZAG1_CAEEL 1.00E-24 GO:0007411; GO:0046872; GO:0000122; GO:0005634; GO:0045773; GO:0043565; GO:0003700; GO:0006351 "axon guidance; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of axon extension; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; IPR007087; IPR015880; IPR013087; Zinc finger E-box-binding homeobox protein zag-1 (Zinc finger involved in axon guidance 1) (ZAG-1) zag-1 F28F9.1 Caenorhabditis elegans TR39836_c0_g1_i2 Q969G3 SMCE1_HUMAN 8.00E-29 GO:0003677; GO:0008080; GO:0016514; GO:0003682; GO:0006338; GO:0071565; GO:0045892; GO:0007399; GO:0071564; GO:0000228; GO:0006337; GO:0006357; GO:0003713; GO:0017053 Q68CP9; Q9HCU9; Q9UKL0 "DNA binding; N-acetyltransferase activity; SWI/SNF complex; chromatin binding; chromatin remodeling; nBAF complex; negative regulation of transcription, DNA-dependent; nervous system development; npBAF complex; nuclear chromosome; nucleosome disassembly; regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcriptional repressor complex" IPR009071; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57) SMARCE1 BAF57 Homo sapiens (Human) TR39836_c0_g1_i3 G5EBU4 ZAG1_CAEEL 4.00E-24 GO:0007411; GO:0046872; GO:0000122; GO:0005634; GO:0045773; GO:0043565; GO:0003700; GO:0006351 "axon guidance; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of axon extension; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; IPR007087; IPR015880; IPR013087; Zinc finger E-box-binding homeobox protein zag-1 (Zinc finger involved in axon guidance 1) (ZAG-1) zag-1 F28F9.1 Caenorhabditis elegans TR39836_c0_g1_i6 O54941 SMCE1_MOUSE 3.00E-71 GO:0003677; GO:0008080; GO:0003723; GO:0016514; GO:0006338; GO:0071565; GO:0045892; GO:0007399; GO:0071564; GO:0006337; GO:0017053 "DNA binding; N-acetyltransferase activity; RNA binding; SWI/SNF complex; chromatin remodeling; nBAF complex; negative regulation of transcription, DNA-dependent; nervous system development; npBAF complex; nucleosome disassembly; transcriptional repressor complex" IPR009071; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57) Smarce1 Baf57 Mus musculus (Mouse) TR39836_c0_g1_i8 Q969G3 SMCE1_HUMAN 1.00E-71 GO:0003677; GO:0008080; GO:0016514; GO:0003682; GO:0006338; GO:0071565; GO:0045892; GO:0007399; GO:0071564; GO:0000228; GO:0006337; GO:0006357; GO:0003713; GO:0017053 Q68CP9; Q9HCU9; Q9UKL0 "DNA binding; N-acetyltransferase activity; SWI/SNF complex; chromatin binding; chromatin remodeling; nBAF complex; negative regulation of transcription, DNA-dependent; nervous system development; npBAF complex; nuclear chromosome; nucleosome disassembly; regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcriptional repressor complex" IPR009071; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57) SMARCE1 BAF57 Homo sapiens (Human) TR39838_c1_g1_i1 Q05437 PRRX1_CHICK 6.00E-40 GO:0007275; GO:0005634; GO:0043565; GO:0003700 multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR017970; IPR001356; IPR009057; IPR003654; Paired mesoderm homeobox protein 1 (GMHOX) (Homeobox protein MHOX) (Paired-related homeobox protein 1) (PRX-1) PRRX1 MHOX PMX1 PRX1 Gallus gallus (Chicken) TR39839_c0_g1_i9 P40938 RFC3_HUMAN 0 GO:0003689; GO:0005663; GO:0006271; GO:0000731; GO:0000278; GO:0005654; GO:0000166; GO:0006297; GO:0046683; GO:0000722; GO:0032201; GO:0006283 P35249 "DNA clamp loader activity; DNA replication factor C complex; DNA strand elongation involved in DNA replication; DNA synthesis involved in DNA repair; mitotic cell cycle; nucleoplasm; nucleotide binding; nucleotide-excision repair, DNA gap filling; response to organophosphorus; telomere maintenance via recombination; telomere maintenance via semi-conservative replication; transcription-coupled nucleotide-excision repair" IPR003593; IPR008921; IPR027417; IPR013748; Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38) RFC3 Homo sapiens (Human) TR39840_c4_g1_i1 O70131 NINJ1_MOUSE 4.00E-07 GO:0007155; GO:0016021; GO:0042246 cell adhesion; integral to membrane; tissue regeneration IPR007007; IPR015639; Ninjurin-1 (Nerve injury-induced protein 1) Ninj1 Mus musculus (Mouse) TR39846_c0_g1_i2 Q5BKX0 TM248_DANRE 2.00E-52 GO:0016021 integral to membrane Transmembrane protein 248 tmem248 zgc:103561 Danio rerio (Zebrafish) (Brachydanio rerio) TR39848_c0_g1_i1 Q9JMA1 UBP14_MOUSE 0 GO:0009986; GO:0008234; GO:0016023; GO:0004866; GO:0005886; GO:0000502; GO:0050920; GO:0061136; GO:0045202; GO:0007268; GO:0004221; GO:0006511 cell surface; cysteine-type peptidase activity; cytoplasmic membrane-bounded vesicle; endopeptidase inhibitor activity; plasma membrane; proteasome complex; regulation of chemotaxis; regulation of proteasomal protein catabolic process; synapse; synaptic transmission; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; IPR019954; IPR000626; Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) Usp14 Mus musculus (Mouse) TR39848_c0_g1_i3 P39967 UBP9_YEAST 4.00E-08 GO:0005737; GO:0016579; GO:0004221; GO:0006511; GO:0004843 cytoplasm; protein deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 9 (EC 3.4.19.12) (Deubiquitinating enzyme 9) (Ubiquitin thioesterase 9) (Ubiquitin-specific-processing protease 9) UBP9 YER098W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39849_c4_g5_i2 A2A559 PGAP3_MOUSE 9.00E-78 GO:0006506; GO:0006505; GO:0000139; GO:0016788; GO:0016021; GO:0031227 "GPI anchor biosynthetic process; GPI anchor metabolic process; Golgi membrane; hydrolase activity, acting on ester bonds; integral to membrane; intrinsic to endoplasmic reticulum membrane" IPR007217; Post-GPI attachment to proteins factor 3 (PER1-like domain-containing protein 1) Pgap3 Perld1 Mus musculus (Mouse) TR3985_c0_g1_i1 Q9NY99 SNTG2_HUMAN 2.00E-23 GO:0007417; GO:0005737; GO:0005856; GO:0005543; GO:0042383; GO:0016013 central nervous system development; cytoplasm; cytoskeleton; phospholipid binding; sarcolemma; syntrophin complex IPR001478; IPR001849; IPR015482; Gamma-2-syntrophin (G2SYN) (Syntrophin-5) (SYN5) SNTG2 Homo sapiens (Human) TR39850_c2_g2_i1 Q32NG4 PDDC1_XENLA 3.00E-72 GO:0005576 extracellular region IPR002818; Parkinson disease 7 domain-containing protein 1 pddc1 Xenopus laevis (African clawed frog) TR39850_c3_g1_i1 P24044 CALM_PLAFA 2.00E-25 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) Plasmodium falciparum TR39850_c3_g1_i2 Q3T0E8 CALL4_BOVIN 2.00E-33 GO:0005509 calcium ion binding IPR011992; IPR002048; Calmodulin-like protein 4 CALML4 Bos taurus (Bovine) TR39851_c1_g2_i1 Q8NDA8 HTR7A_HUMAN 3.00E-95 IPR011989; IPR016024; IPR000357; IPR021133; Maestro heat-like repeat-containing protein family member 1 (HEAT repeat-containing protein 7A) MROH1 HEATR7A KIAA1833 Homo sapiens (Human) TR39851_c1_g2_i2 Q8NDA8 HTR7A_HUMAN 3.00E-27 IPR011989; IPR016024; IPR000357; IPR021133; Maestro heat-like repeat-containing protein family member 1 (HEAT repeat-containing protein 7A) MROH1 HEATR7A KIAA1833 Homo sapiens (Human) TR39852_c0_g1_i3 O94632 MU158_SCHPO 2.00E-09 GO:0005509; GO:0005829; GO:0005788; GO:0007126; GO:0005634 calcium ion binding; cytosol; endoplasmic reticulum lumen; meiosis; nucleus IPR016187; IPR005532; IPR019257; IPR017805; Meiotically up-regulated gene 158 protein mug158 SPBC1604.01 SPBC1677.01c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR39855_c1_g1_i1 Q9GZR7 DDX24_HUMAN 1.00E-147 GO:0005524; GO:0004004; GO:0003723; GO:0016070; GO:0005737; GO:0005730 ATP binding; ATP-dependent RNA helicase activity; RNA binding; RNA metabolic process; cytoplasm; nucleolus IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24) DDX24 Homo sapiens (Human) TR39856_c4_g5_i4 Q9JJW0 PXMP4_MOUSE 6.00E-82 GO:0016021; GO:0005778 integral to membrane; peroxisomal membrane IPR019531; IPR003397; Peroxisomal membrane protein 4 (24 kDa peroxisomal intrinsic membrane protein) Pxmp4 Pmp24 Mus musculus (Mouse) TR39857_c0_g3_i1 P82160 MLE3_LIZRA 1.00E-35 GO:0005509; GO:0016459 calcium ion binding; myosin complex IPR011992; IPR002048; "Myosin light chain 3, skeletal muscle isoform (LC-3) (LC3) (Myosin light chain alkali 2) (Myosin light chain A2)" Liza ramada (Thin-lipped grey mullet) (Mugil capito) TR39857_c0_g3_i2 P54357 MLC2_DROME 2.00E-64 GO:0030048; GO:0005509; GO:0016460; GO:0031475; GO:0031476; GO:0031477 actin filament-based movement; calcium ion binding; myosin II complex; myosin V complex; myosin VI complex; myosin VII complex IPR011992; IPR018247; IPR002048; Myosin-2 essential light chain (Myosin II essential light chain) (Non-muscle myosin essential light chain) Mlc-c CG3201 Drosophila melanogaster (Fruit fly) TR39860_c7_g1_i1 P78312 F193A_HUMAN 9.00E-15 GO:0005737; GO:0005886 cytoplasm; plasma membrane Protein FAM193A (Protein IT14) FAM193A C4orf8 RES4-22 Homo sapiens (Human) TR39860_c7_g1_i5 A7MB40 F193B_BOVIN 5.00E-07 IPR026809; Protein FAM193B FAM193B Bos taurus (Bovine) TR39861_c1_g2_i1 Q6P6Y1 K1468_DANRE 0 IPR011989; IPR016024; IPR021133; IPR006594; LisH domain and HEAT repeat-containing protein KIAA1468 homolog zgc:66014 Danio rerio (Zebrafish) (Brachydanio rerio) TR39861_c1_g2_i3 Q6P6Y1 K1468_DANRE 0 IPR011989; IPR016024; IPR021133; IPR006594; LisH domain and HEAT repeat-containing protein KIAA1468 homolog zgc:66014 Danio rerio (Zebrafish) (Brachydanio rerio) TR39863_c1_g3_i1 Q7T0L6 CCNF_XENLA 2.00E-80 GO:0019005; GO:0031146; GO:0051301; GO:0005814; GO:0007067; GO:0010826; GO:0005634; GO:0016567 SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; centriole; mitosis; negative regulation of centrosome duplication; nucleus; protein ubiquitination IPR013763; IPR004367; IPR006671; IPR001810; IPR011990; Cyclin-F ccnf Xenopus laevis (African clawed frog) TR39865_c0_g1_i2 Q24248 ARA_DROME 2.00E-19 GO:0003705; GO:0045317; GO:0007474; GO:0042693; GO:0035310; GO:0005634; GO:0045944; GO:0043565 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; equator specification; imaginal disc-derived wing vein specification; muscle cell fate commitment; notum cell fate specification; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding IPR017970; IPR001356; IPR008422; IPR009057; Homeobox protein araucan ara CG10571 Drosophila melanogaster (Fruit fly) TR39865_c0_g1_i3 Q9YGK8 IRX1A_XENLA 1.00E-20 GO:0060062; GO:0009953; GO:0072005; GO:0007498; GO:0030917; GO:0030514; GO:0045665; GO:0000122; GO:0014036; GO:0005634; GO:0045666; GO:0045944; GO:0072196; GO:0043565; GO:0003700; GO:0039005; GO:0044212; GO:0006351 "Spemann organizer formation at the dorsal lip of the blastopore; dorsal/ventral pattern formation; maintenance of kidney identity; mesoderm development; midbrain-hindbrain boundary development; negative regulation of BMP signaling pathway; negative regulation of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; neural crest cell fate specification; nucleus; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; proximal/distal pattern formation involved in pronephric nephron development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; specification of pronephric tubule identity; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR017970; IPR001356; IPR008422; IPR009057; IPR003893; Iroquois-class homeodomain protein irx-1-A (Iroquois homeobox protein 1-A) (Xiro-1) (Xiro1) irx1-a iro1 iro1-a irx1 Xenopus laevis (African clawed frog) TR39866_c0_g1_i1 P43147 EMPA_VIBAN 1.00E-44 GO:0005576; GO:0046872; GO:0004222; GO:0009405; GO:0006508 extracellular region; metal ion binding; metalloendopeptidase activity; pathogenesis; proteolysis IPR011096; IPR025711; IPR007280; IPR023612; IPR001570; IPR013856; Virulence metalloprotease (EC 3.4.24.-) (Vibriolysin) empA Vibrio anguillarum (Listonella anguillarum) TR39866_c0_g1_i2 P43147 EMPA_VIBAN 1.00E-52 GO:0005576; GO:0046872; GO:0004222; GO:0009405; GO:0006508 extracellular region; metal ion binding; metalloendopeptidase activity; pathogenesis; proteolysis IPR011096; IPR025711; IPR007280; IPR023612; IPR001570; IPR013856; Virulence metalloprotease (EC 3.4.24.-) (Vibriolysin) empA Vibrio anguillarum (Listonella anguillarum) TR39867_c0_g2_i12 Q8VIK1 SNR25_MOUSE 3.00E-22 GO:0008380; GO:0005689; GO:0006397 RNA splicing; U12-type spliceosomal complex; mRNA processing U11/U12 small nuclear ribonucleoprotein 25 kDa protein (U11/U12 snRNP 25 kDa protein) Snrnp25 Mus musculus (Mouse) TR39867_c0_g2_i5 Q8VIK1 SNR25_MOUSE 7.00E-44 GO:0008380; GO:0005689; GO:0006397 RNA splicing; U12-type spliceosomal complex; mRNA processing U11/U12 small nuclear ribonucleoprotein 25 kDa protein (U11/U12 snRNP 25 kDa protein) Snrnp25 Mus musculus (Mouse) TR39868_c0_g3_i2 Q5ZKX1 CHM1B_CHICK 8.00E-76 GO:0005829; GO:0031902; GO:0015031 cytosol; late endosome membrane; protein transport IPR005024; Charged multivesicular body protein 1b (Chromatin-modifying protein 1b) (CHMP1b) CHMP1B RCJMB04_8n10 Gallus gallus (Chicken) TR39868_c0_g3_i4 O96552 CHMP1_DICDI 1.00E-56 GO:0010008; GO:0005770; GO:0045324; GO:0006623 endosome membrane; late endosome; late endosome to vacuole transport; protein targeting to vacuole IPR005024; Charged multivesicular body protein 1 (Developmental gene 1118 protein) (Vacuolar protein-sorting-associated protein 46) chmp1 DG1118 vps46 DDB_G0267394 Dictyostelium discoideum (Slime mold) TR39869_c1_g5_i1 Q761V0 SC6A5_MOUSE 5.00E-171 GO:0016021; GO:0005328 integral to membrane; neurotransmitter:sodium symporter activity IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) Slc6a5 Glyt2 Mus musculus (Mouse) TR39871_c2_g3_i1 Q7G191 ALDO4_ARATH 2.00E-46 GO:0051537; GO:0009688; GO:0018488; GO:0009851; GO:0018479; GO:0005829; GO:0009055; GO:0050660; GO:0019760; GO:0050302; GO:0005506; GO:0016614 "2 iron, 2 sulfur cluster binding; abscisic acid biosynthetic process; aryl-aldehyde oxidase activity; auxin biosynthetic process; benzaldehyde dehydrogenase (NAD+) activity; cytosol; electron carrier activity; flavin adenine dinucleotide binding; glucosinolate metabolic process; indole-3-acetaldehyde oxidase activity; iron ion binding; oxidoreductase activity, acting on CH-OH group of donors" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR002346; Benzaldehyde dehydrogenase (NAD(+)) (EC 1.2.1.28) (Aldehyde oxidase 4) (AO-4) (AtAO-4) (AtAO2) (Indole-3-acetaldehyde oxidase) (IAA oxidase) (EC 1.2.3.7) AAO4 AO2 At1g04580 T1G11.17 Arabidopsis thaliana (Mouse-ear cress) TR39871_c2_g3_i2 P47990 XDH_CHICK 0 GO:0051537; GO:0008762; GO:0005829; GO:0009055; GO:0050660; GO:0005506; GO:0030151; GO:0043546; GO:0005777; GO:0034418; GO:0009115; GO:0004854; GO:0004855 "2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; cytosol; electron carrier activity; flavin adenine dinucleotide binding; iron ion binding; molybdenum ion binding; molybdopterin cofactor binding; peroxisome; urate biosynthetic process; xanthine catabolic process; xanthine dehydrogenase activity; xanthine oxidase activity" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; IPR022407; IPR014309; IPR014307; Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] XDH Gallus gallus (Chicken) TR39871_c2_g3_i5 P08793 XDH_CALVI 3.00E-127 GO:0051537; GO:0008762; GO:0009055; GO:0050660; GO:0005506; GO:0043546; GO:0005777; GO:0009115; GO:0004854; GO:0004855 "2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; electron carrier activity; flavin adenine dinucleotide binding; iron ion binding; molybdopterin cofactor binding; peroxisome; xanthine catabolic process; xanthine dehydrogenase activity; xanthine oxidase activity" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; IPR022407; IPR014307; Xanthine dehydrogenase (XD) (EC 1.17.1.4) XDH Calliphora vicina (Blue blowfly) (Calliphora erythrocephala) TR39871_c2_g3_i8 P47990 XDH_CHICK 0 GO:0051537; GO:0008762; GO:0005829; GO:0009055; GO:0050660; GO:0005506; GO:0030151; GO:0043546; GO:0005777; GO:0034418; GO:0009115; GO:0004854; GO:0004855 "2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; cytosol; electron carrier activity; flavin adenine dinucleotide binding; iron ion binding; molybdenum ion binding; molybdopterin cofactor binding; peroxisome; urate biosynthetic process; xanthine catabolic process; xanthine dehydrogenase activity; xanthine oxidase activity" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; IPR022407; IPR014309; IPR014307; Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] XDH Gallus gallus (Chicken) TR39872_c2_g1_i1 O76050 NEU1A_HUMAN 4.00E-12 GO:0007219; GO:0007420; GO:0007595; GO:0016874; GO:0007399; GO:0048471; GO:0005886; GO:0016567; GO:0009605; GO:0007519; GO:0007288; GO:0030317; GO:0008270 Notch signaling pathway; brain development; lactation; ligase activity; nervous system development; perinuclear region of cytoplasm; plasma membrane; protein ubiquitination; response to external stimulus; skeletal muscle tissue development; sperm axoneme assembly; sperm motility; zinc ion binding IPR006573; IPR001841; IPR013083; Protein modification; protein ubiquitination. Neuralized-like protein 1A (h-neu) (h-neuralized 1) (EC 6.3.2.-) (RING finger protein 67) NEURL NEURL1 NEURL1A RNF67 Homo sapiens (Human) TR39872_c3_g1_i1 O43900 PRIC3_HUMAN 1.00E-54 GO:0008270 P00519; P06241 zinc ion binding IPR010442; IPR001781; Prickle-like protein 3 (LIM domain only protein 6) (LMO-6) (Triple LIM domain protein 6) PRICKLE3 LMO6 Homo sapiens (Human) TR39872_c3_g1_i3 Q2QLE3 TES_PIG 2.00E-47 GO:0005737; GO:0005925; GO:0008285; GO:0008270 cytoplasm; focal adhesion; negative regulation of cell proliferation; zinc ion binding IPR010442; IPR027683; IPR001781; Testin TES Sus scrofa (Pig) TR39872_c4_g3_i3 O62640 PIAP_PIG 3.00E-48 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR39874_c1_g1_i1 Q5ZIU8 KTNB1_CHICK 4.00E-11 GO:0030424; GO:0051301; GO:0005813; GO:0008352; GO:0005874; GO:0051013; GO:0008568; GO:0007067; GO:0007026; GO:0005886; GO:0031117; GO:0000922 axon; cell division; centrosome; katanin complex; microtubule; microtubule severing; microtubule-severing ATPase activity; mitosis; negative regulation of microtubule depolymerization; plasma membrane; positive regulation of microtubule depolymerization; spindle pole IPR020472; IPR026962; IPR028021; IPR015943; IPR001680; IPR019775; IPR017986; Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) KATNB1 RCJMB04_23h13 Gallus gallus (Chicken) TR39874_c1_g1_i2 P14197 AAC3_DICDI 8.00E-06 IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein AAC3 (AAC-rich mRNA clone AAC3 protein) AAC3 DDB_G0276031 Dictyostelium discoideum (Slime mold) TR39874_c1_g1_i3 Q00808 HETE1_PODAS 3.00E-11 GO:0005525 GTP binding IPR020472; IPR010730; IPR007111; IPR027417; IPR015943; IPR001680; IPR019775; IPR017986; Vegetative incompatibility protein HET-E-1 HET-E1 Podospora anserina (Pleurage anserina) TR39874_c1_g1_i4 Q9DB94 WDR53_MOUSE 9.00E-57 IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 53 Wdr53 Mus musculus (Mouse) TR39877_c0_g1_i3 P08472 M130_STRPU 3.00E-32 GO:0031225; GO:0016787; GO:0009166; GO:0005886 anchored to membrane; hydrolase activity; nucleotide catabolic process; plasma membrane IPR006179; IPR015943; Mesenchyme-specific cell surface glycoprotein (MSP130) Strongylocentrotus purpuratus (Purple sea urchin) TR39877_c0_g1_i4 P86786 GIGA3_CRAGI 2.00E-48 GO:0016787; GO:0009166 hydrolase activity; nucleotide catabolic process IPR006179; Gigasin-3a (Fragment) Crassostrea gigas (Pacific oyster) (Crassostrea angulata) TR39879_c0_g1_i1 Q13351 KLF1_HUMAN 3.00E-48 GO:0006338; GO:0000987; GO:0035162; GO:0030218; GO:0043249; GO:0001701; GO:0001889; GO:0046872; GO:0000790; GO:0045893; GO:0003700; GO:0006351 "chromatin remodeling; core promoter proximal region sequence-specific DNA binding; embryonic hemopoiesis; erythrocyte differentiation; erythrocyte maturation; in utero embryonic development; liver development; metal ion binding; nuclear chromatin; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Krueppel-like factor 1 (Erythroid krueppel-like transcription factor) (EKLF) KLF1 EKLF Homo sapiens (Human) TR39880_c1_g1_i1 Q32N55 PTCD3_XENLA 6.00E-86 GO:0032543; GO:0005739; GO:0019843; GO:0006417; GO:0043024 mitochondrial translation; mitochondrion; rRNA binding; regulation of translation; ribosomal small subunit binding IPR002885; "Pentatricopeptide repeat domain-containing protein 3, mitochondrial" ptcd3 Xenopus laevis (African clawed frog) TR39880_c1_g1_i2 A1Z9A8 PTCD3_DROME 2.00E-27 GO:0032543; GO:0005739; GO:0019843; GO:0006417; GO:0043024 mitochondrial translation; mitochondrion; rRNA binding; regulation of translation; ribosomal small subunit binding IPR002885; "Protein PTCD3 homolog, mitochondrial" CG4679 Drosophila melanogaster (Fruit fly) TR39881_c5_g1_i1 Q62314 TGON2_MOUSE 8.00E-14 GO:0016021; GO:0005886; GO:0005802; GO:0030140 integral to membrane; plasma membrane; trans-Golgi network; trans-Golgi network transport vesicle IPR026084; Trans-Golgi network integral membrane protein 2 (TGN38B) Tgoln2 Ttgn2 Mus musculus (Mouse) TR39881_c6_g1_i1 Q9W6F8 WIF1_XENLA 8.00E-19 GO:0016055; GO:0005576; GO:0007275 Wnt receptor signaling pathway; extracellular region; multicellular organismal development IPR000742; IPR013032; IPR003306; IPR013309; Wnt inhibitory factor 1 (WIF-1) wif1 Xenopus laevis (African clawed frog) TR39881_c6_g1_i3 Q9W6F9 WIF1_DANRE 3.00E-15 GO:0016055; GO:0005576; GO:0090090; GO:0048794 Wnt receptor signaling pathway; extracellular region; negative regulation of canonical Wnt receptor signaling pathway; swim bladder development IPR000742; IPR013032; IPR013111; IPR003306; IPR013309; Wnt inhibitory factor 1 (WIF-1) wif1 Danio rerio (Zebrafish) (Brachydanio rerio) TR39881_c6_g1_i5 Q9W6F8 WIF1_XENLA 4.00E-20 GO:0016055; GO:0005576; GO:0007275 Wnt receptor signaling pathway; extracellular region; multicellular organismal development IPR000742; IPR013032; IPR003306; IPR013309; Wnt inhibitory factor 1 (WIF-1) wif1 Xenopus laevis (African clawed frog) TR39882_c0_g1_i1 Q91Y63 S13A3_MOUSE 7.00E-137 GO:0015362; GO:0016021; GO:0016020; GO:0005886 high affinity sodium:dicarboxylate symporter activity; integral to membrane; membrane; plasma membrane IPR001898; Solute carrier family 13 member 3 (Na(+)/dicarboxylate cotransporter 3) (NaDC-3) (mNaDC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) Slc13a3 Nadc3 Sdct2 Mus musculus (Mouse) TR39883_c0_g1_i3 Q5RBM1 RPN2_PONAB 9.00E-140 GO:0016021; GO:0008250; GO:0006487; GO:0016757 "integral to membrane; oligosaccharyltransferase complex; protein N-linked glycosylation; transferase activity, transferring glycosyl groups" IPR008814; Protein modification; protein glycosylation. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (EC 2.4.99.18) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (Ribophorin II) (RPN-II) (Ribophorin-2) RPN2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39883_c0_g1_i4 Q5RBM1 RPN2_PONAB 3.00E-138 GO:0016021; GO:0008250; GO:0006487; GO:0016757 "integral to membrane; oligosaccharyltransferase complex; protein N-linked glycosylation; transferase activity, transferring glycosyl groups" IPR008814; Protein modification; protein glycosylation. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (EC 2.4.99.18) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (Ribophorin II) (RPN-II) (Ribophorin-2) RPN2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR39885_c0_g1_i2 Q9P2Y5 UVRAG_HUMAN 3.00E-70 GO:0006281; GO:0005769; GO:0005770; GO:0005764; GO:0010508; GO:0043234 Q07812; Q14457; Q9Y371 DNA repair; early endosome; late endosome; lysosome; positive regulation of autophagy; protein complex IPR000008; IPR018791; UV radiation resistance-associated gene protein (p63) UVRAG Homo sapiens (Human) TR39885_c0_g1_i4 Q9VK07 UVRAG_DROME 4.00E-12 GO:0007219; GO:0048803; GO:0045746; GO:0008285; GO:0010508; GO:0048260; GO:0040008 Notch signaling pathway; imaginal disc-derived male genitalia morphogenesis; negative regulation of Notch signaling pathway; negative regulation of cell proliferation; positive regulation of autophagy; positive regulation of receptor-mediated endocytosis; regulation of growth IPR018791; UV radiation resistance-associated gene protein (UV-resistance associated gene) Uvrag CG6116 Drosophila melanogaster (Fruit fly) TR39886_c4_g1_i1 P14381 YTX2_XENLA 6.00E-41 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR39886_c5_g1_i3 Q8NFH3 NUP43_HUMAN 1.00E-106 GO:0005975; GO:0051301; GO:0007059; GO:0000777; GO:0019221; GO:0005829; GO:0015758; GO:0051028; GO:0007067; GO:0007077; GO:0031080; GO:0015031; GO:0010827; GO:0044281; GO:0055085; GO:0016032 carbohydrate metabolic process; cell division; chromosome segregation; condensed chromosome kinetochore; cytokine-mediated signaling pathway; cytosol; glucose transport; mRNA transport; mitosis; mitotic nuclear envelope disassembly; nuclear pore outer ring; protein transport; regulation of glucose transport; small molecule metabolic process; transmembrane transport; viral process IPR015943; IPR001680; IPR019775; IPR017986; Nucleoporin Nup43 (Nup107-160 subcomplex subunit Nup43) (p42) NUP43 Homo sapiens (Human) TR39889_c7_g3_i1 Q6Q759 SPG17_HUMAN 2.00E-71 GO:0005737; GO:0005874; GO:0005634; GO:0036126 cytoplasm; microtubule; nucleus; sperm flagellum IPR026173; Sperm-associated antigen 17 (Projection protein PF6 homolog) SPAG17 Homo sapiens (Human) TR39889_c7_g3_i2 Q5S003 SPG17_MOUSE 1.00E-29 GO:0005737; GO:0005874; GO:0036126 Q9JLI7 cytoplasm; microtubule; sperm flagellum IPR026173; Sperm-associated antigen 17 (Projection protein PF6 homolog) Spag17 Mus musculus (Mouse) TR39890_c0_g1_i1 Q24731 DDX1_DROVI 6.00E-151 GO:0005524; GO:0008026; GO:0032508; GO:0033677; GO:0003682; GO:0006302; GO:0001700; GO:0004527; GO:0004518; GO:0005634; GO:0008143; GO:0003712 ATP binding; ATP-dependent helicase activity; DNA duplex unwinding; DNA/RNA helicase activity; chromatin binding; double-strand break repair; embryonic development via the syncytial blastoderm; exonuclease activity; nuclease activity; nucleus; poly(A) RNA binding; transcription cofactor activity IPR011545; IPR001650; IPR027417; ATP-dependent RNA helicase Ddx1 (EC 3.6.4.13) (DEAD box protein 1) (Fragment) Ddx1 Drosophila virilis (Fruit fly) TR39890_c0_g1_i2 Q90WU3 DDX1_CHICK 0 GO:0005524; GO:0008026; GO:0003677; GO:0032508; GO:0033677; GO:0003682; GO:0005737; GO:0006302; GO:0004527; GO:0006397; GO:0004518; GO:0005634; GO:0008143; GO:0006355; GO:0072669; GO:0003712; GO:0006351 "ATP binding; ATP-dependent helicase activity; DNA binding; DNA duplex unwinding; DNA/RNA helicase activity; chromatin binding; cytoplasm; double-strand break repair; exonuclease activity; mRNA processing; nuclease activity; nucleus; poly(A) RNA binding; regulation of transcription, DNA-dependent; tRNA-splicing ligase complex; transcription cofactor activity; transcription, DNA-dependent" IPR001870; IPR008985; IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; IPR018355; IPR003877; ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) DDX1 Gallus gallus (Chicken) TR39891_c3_g2_i3 Q9XIE6 ALA3_ARATH 0 GO:0005524; GO:0005794; GO:0000139; GO:0048194; GO:0019829; GO:0005789; GO:0005768; GO:0016021; GO:0000287; GO:0005548; GO:0004012; GO:0005886; GO:0048364; GO:0048367; GO:0005802 ATP binding; Golgi apparatus; Golgi membrane; Golgi vesicle budding; cation-transporting ATPase activity; endoplasmic reticulum membrane; endosome; integral to membrane; magnesium ion binding; phospholipid transporter activity; phospholipid-translocating ATPase activity; plasma membrane; root development; shoot system development; trans-Golgi network IPR023299; IPR018303; IPR006539; IPR008250; IPR001757; IPR023214; Phospholipid-transporting ATPase 3 (AtALA3) (EC 3.6.3.1) (Aminophospholipid ATPase 3) (Aminophospholipid flippase 3) (Protein IRREGULAR TRICHOME BRANCH 2) ALA3 ITB2 At1g59820 F23H11.14 Arabidopsis thaliana (Mouse-ear cress) TR39891_c3_g2_i4 P70704 AT8A1_MOUSE 0 GO:0005524; GO:0019829; GO:0042584; GO:0005783; GO:0016021; GO:0000287; GO:0004012; GO:0005886 ATP binding; cation-transporting ATPase activity; chromaffin granule membrane; endoplasmic reticulum; integral to membrane; magnesium ion binding; phospholipid-translocating ATPase activity; plasma membrane IPR023299; IPR018303; IPR006539; IPR008250; IPR001757; IPR023214; Probable phospholipid-transporting ATPase IA (EC 3.6.3.1) (ATPase class I type 8A member 1) (Chromaffin granule ATPase II) Atp8a1 Atpc1 Mus musculus (Mouse) TR39891_c3_g2_i5 P70704 AT8A1_MOUSE 0 GO:0005524; GO:0019829; GO:0042584; GO:0005783; GO:0016021; GO:0000287; GO:0004012; GO:0005886 ATP binding; cation-transporting ATPase activity; chromaffin granule membrane; endoplasmic reticulum; integral to membrane; magnesium ion binding; phospholipid-translocating ATPase activity; plasma membrane IPR023299; IPR018303; IPR006539; IPR008250; IPR001757; IPR023214; Probable phospholipid-transporting ATPase IA (EC 3.6.3.1) (ATPase class I type 8A member 1) (Chromaffin granule ATPase II) Atp8a1 Atpc1 Mus musculus (Mouse) TR39893_c2_g3_i1 Q8N539 FBCD1_HUMAN 6.00E-36 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 UNQ701/PRO1346 Homo sapiens (Human) TR39893_c2_g3_i3 A2AV25 FBCD1_MOUSE 2.00E-36 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 Fibcd1 Mus musculus (Mouse) TR39893_c2_g3_i4 Q15389 ANGP1_HUMAN 6.00E-41 GO:0048014; GO:0007171; GO:0007596; GO:0030154; GO:0031589; GO:0005615; GO:0072012; GO:0030097; GO:0030210; GO:0001701; GO:0050900; GO:0045121; GO:0005902; GO:0007162; GO:2000352; GO:0043116; GO:0005886; GO:0050918; GO:0070374; GO:0043536; GO:0045785; GO:0033138; GO:0050731; GO:0014068; GO:0051897; GO:0031398; GO:0002092; GO:0034394; GO:0014842; GO:0002040 Tie signaling pathway; activation of transmembrane receptor protein tyrosine kinase activity; blood coagulation; cell differentiation; cell-substrate adhesion; extracellular space; glomerulus vasculature development; hemopoiesis; heparin biosynthetic process; in utero embryonic development; leukocyte migration; membrane raft; microvillus; negative regulation of cell adhesion; negative regulation of endothelial cell apoptotic process; negative regulation of vascular permeability; plasma membrane; positive chemotaxis; positive regulation of ERK1 and ERK2 cascade; positive regulation of blood vessel endothelial cell migration; positive regulation of cell adhesion; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of protein ubiquitination; positive regulation of receptor internalization; protein localization to cell surface; regulation of satellite cell proliferation; sprouting angiogenesis IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-1 (ANG-1) ANGPT1 KIAA0003 Homo sapiens (Human) TR39893_c2_g5_i1 Q60529 RASH_MESAU 1.00E-10 GO:0005525; GO:0003924; GO:0005794; GO:0000139; GO:0005886; GO:0007264 GTP binding; GTPase activity; Golgi apparatus; Golgi membrane; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; "GTPase HRas (H-Ras-1) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed] (Fragment)" HRAS1 HRAS Mesocricetus auratus (Golden hamster) TR39893_c2_g5_i2 Q6RUV5 RAC1_RAT 2.00E-114 GO:0005525; GO:0003924; GO:0000139; GO:0016601; GO:0060071; GO:0007015; GO:0048532; GO:0002093; GO:0007411; GO:0045453; GO:0008283; GO:0045216; GO:0021799; GO:0090103; GO:0031410; GO:0048813; GO:0071542; GO:0021831; GO:0043652; GO:0003382; GO:0019897; GO:0006972; GO:0030027; GO:0030032; GO:0002551; GO:0042470; GO:0001891; GO:0045740; GO:0030838; GO:0043552; GO:0001934; GO:0030334; GO:0097178; GO:0032587; GO:0034446 "GTP binding; GTPase activity; Golgi membrane; Rac protein signal transduction; Wnt receptor signaling pathway, planar cell polarity pathway; actin filament organization; anatomical structure arrangement; auditory receptor cell morphogenesis; axon guidance; bone resorption; cell proliferation; cell-cell junction organization; cerebral cortex radially oriented cell migration; cochlea morphogenesis; cytoplasmic vesicle; dendrite morphogenesis; dopaminergic neuron differentiation; embryonic olfactory bulb interneuron precursor migration; engulfment of apoptotic cell; epithelial cell morphogenesis; extrinsic to plasma membrane; hyperosmotic response; lamellipodium; lamellipodium assembly; mast cell chemotaxis; melanosome; phagocytic cup; positive regulation of DNA replication; positive regulation of actin filament polymerization; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein phosphorylation; regulation of cell migration; ruffle assembly; ruffle membrane; substrate adhesion-dependent cell spreading" IPR027417; IPR005225; IPR001806; IPR003578; Ras-related C3 botulinum toxin substrate 1 (p21-Rac1) Rac1 Rattus norvegicus (Rat) TR39893_c2_g5_i3 Q6RUV5 RAC1_RAT 2.00E-121 GO:0005525; GO:0003924; GO:0000139; GO:0016601; GO:0060071; GO:0007015; GO:0048532; GO:0002093; GO:0007411; GO:0045453; GO:0008283; GO:0045216; GO:0021799; GO:0090103; GO:0031410; GO:0048813; GO:0071542; GO:0021831; GO:0043652; GO:0003382; GO:0019897; GO:0006972; GO:0030027; GO:0030032; GO:0002551; GO:0042470; GO:0001891; GO:0045740; GO:0030838; GO:0043552; GO:0001934; GO:0030334; GO:0097178; GO:0032587; GO:0034446 "GTP binding; GTPase activity; Golgi membrane; Rac protein signal transduction; Wnt receptor signaling pathway, planar cell polarity pathway; actin filament organization; anatomical structure arrangement; auditory receptor cell morphogenesis; axon guidance; bone resorption; cell proliferation; cell-cell junction organization; cerebral cortex radially oriented cell migration; cochlea morphogenesis; cytoplasmic vesicle; dendrite morphogenesis; dopaminergic neuron differentiation; embryonic olfactory bulb interneuron precursor migration; engulfment of apoptotic cell; epithelial cell morphogenesis; extrinsic to plasma membrane; hyperosmotic response; lamellipodium; lamellipodium assembly; mast cell chemotaxis; melanosome; phagocytic cup; positive regulation of DNA replication; positive regulation of actin filament polymerization; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein phosphorylation; regulation of cell migration; ruffle assembly; ruffle membrane; substrate adhesion-dependent cell spreading" IPR027417; IPR005225; IPR001806; IPR003578; Ras-related C3 botulinum toxin substrate 1 (p21-Rac1) Rac1 Rattus norvegicus (Rat) TR39897_c1_g1_i1 Q8IZ83 A16A1_HUMAN 3.00E-53 GO:0016620 "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" IPR016161; IPR016163; IPR016162; IPR011408; IPR015590; Aldehyde dehydrogenase family 16 member A1 ALDH16A1 Homo sapiens (Human) TR39897_c1_g1_i2 Q27640 ALDH_ENCBU 1.00E-25 GO:0004029; GO:0006068 aldehyde dehydrogenase (NAD) activity; ethanol catabolic process IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. Aldehyde dehydrogenase (EC 1.2.1.3) (Aldehyde dehydrogenase [NAD(+)]) ALDH Enchytraeus buchholzi (Grindal worm) TR39897_c1_g3_i1 P40047 ALDH5_YEAST 1.00E-77 GO:0019413; GO:0004029; GO:0004030; GO:0006068; GO:0005759 acetate biosynthetic process; aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; ethanol catabolic process; mitochondrial matrix IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. "Aldehyde dehydrogenase 5, mitochondrial (EC 1.2.1.5)" ALD5 ALD3 ALDH5 YER073W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39899_c0_g2_i2 Q96JG6 CC132_HUMAN 0 IPR019514; IPR019515; Coiled-coil domain-containing protein 132 CCDC132 KIAA1861 Homo sapiens (Human) TR39899_c0_g2_i3 Q8CI71 CC132_MOUSE 0 IPR019514; IPR019515; Coiled-coil domain-containing protein 132 (Bcl2-like protein blm) Ccdc132 Kiaa1861 Mus musculus (Mouse) TR39899_c0_g2_i5 Q96JG6 CC132_HUMAN 0 IPR019514; IPR019515; Coiled-coil domain-containing protein 132 CCDC132 KIAA1861 Homo sapiens (Human) TR39900_c1_g3_i1 Q8IUK8 CBLN2_HUMAN 3.00E-09 GO:0005615; GO:0051965 extracellular space; positive regulation of synapse assembly IPR001073; IPR008983; Cerebellin-2 CBLN2 UNQ1892/PRO4338 Homo sapiens (Human) TR39900_c1_g3_i2 Q8IUK8 CBLN2_HUMAN 7.00E-09 GO:0005615; GO:0051965 extracellular space; positive regulation of synapse assembly IPR001073; IPR008983; Cerebellin-2 CBLN2 UNQ1892/PRO4338 Homo sapiens (Human) TR39900_c1_g3_i6 Q8IUK8 CBLN2_HUMAN 3.00E-09 GO:0005615; GO:0051965 extracellular space; positive regulation of synapse assembly IPR001073; IPR008983; Cerebellin-2 CBLN2 UNQ1892/PRO4338 Homo sapiens (Human) TR39900_c1_g4_i1 Q00780 CO8A1_MOUSE 2.00E-07 GO:0001525; GO:0005604; GO:0048593; GO:0007155; GO:0005581; GO:0050673; GO:0010811 angiogenesis; basement membrane; camera-type eye morphogenesis; cell adhesion; collagen; epithelial cell proliferation; positive regulation of cell-substrate adhesion IPR001073; IPR008160; IPR008983; Collagen alpha-1(VIII) chain [Cleaved into: Vastatin] Col8a1 Mus musculus (Mouse) TR39900_c1_g4_i3 Q4ZJM9 C1QL4_MOUSE 1.00E-08 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) TR39900_c1_g4_i4 Q9BXX0 EMIL2_HUMAN 1.00E-06 GO:0007155; GO:0005581; GO:0030023; GO:0005576 cell adhesion; collagen; extracellular matrix constituent conferring elasticity; extracellular region IPR001073; IPR011489; IPR008983; EMILIN-2 (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10) EMILIN2 Homo sapiens (Human) TR39900_c1_g4_i6 Q00780 CO8A1_MOUSE 6.00E-08 GO:0001525; GO:0005604; GO:0048593; GO:0007155; GO:0005581; GO:0050673; GO:0010811 angiogenesis; basement membrane; camera-type eye morphogenesis; cell adhesion; collagen; epithelial cell proliferation; positive regulation of cell-substrate adhesion IPR001073; IPR008160; IPR008983; Collagen alpha-1(VIII) chain [Cleaved into: Vastatin] Col8a1 Mus musculus (Mouse) TR39901_c1_g1_i1 Q9V9J3 SRC42_DROME 1.00E-18 GO:0005524; GO:0007254; GO:0051017; GO:0005912; GO:0034332; GO:0043277; GO:0048749; GO:0007395; GO:0090136; GO:0046529; GO:0007476; GO:0042059; GO:0045886; GO:0004715; GO:0007424; GO:0004713; GO:0007435; GO:0007169; GO:0006099 "ATP binding; JNK cascade; actin filament bundle assembly; adherens junction; adherens junction organization; apoptotic cell clearance; compound eye development; dorsal closure, spreading of leading edge cells; epithelial cell-cell adhesion; imaginal disc fusion, thorax closure; imaginal disc-derived wing morphogenesis; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of synaptic growth at neuromuscular junction; non-membrane spanning protein tyrosine kinase activity; open tracheal system development; protein tyrosine kinase activity; salivary gland morphogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; tricarboxylic acid cycle" IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Tyrosine-protein kinase Src41) (Dsrc41) Src42A Src41 TK5 CG44128 Drosophila melanogaster (Fruit fly) TR39901_c1_g3_i1 P21709 EPHA1_HUMAN 1.00E-64 GO:0005524; GO:0032862; GO:0001525; GO:0005887; GO:0030336; GO:0006469; GO:0045766; GO:0030335; GO:0008284; GO:0001954; GO:0051496; GO:0046777; GO:0032314; GO:0034446; GO:0005005 ATP binding; activation of Rho GTPase activity; angiogenesis; integral to plasma membrane; negative regulation of cell migration; negative regulation of protein kinase activity; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of stress fiber assembly; protein autophosphorylation; regulation of Rac GTPase activity; substrate adhesion-dependent cell spreading; transmembrane-ephrin receptor activity IPR027936; IPR001090; IPR003961; IPR008979; IPR009030; IPR013783; IPR011009; IPR000719; IPR017441; IPR001660; IPR013761; IPR021129; IPR001245; IPR008266; IPR020635; IPR016257; IPR001426; Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH) EPHA1 EPH EPHT EPHT1 Homo sapiens (Human) TR39901_c1_g3_i2 Q9V9J3 SRC42_DROME 0 GO:0005524; GO:0007254; GO:0051017; GO:0005912; GO:0034332; GO:0043277; GO:0048749; GO:0007395; GO:0090136; GO:0046529; GO:0007476; GO:0042059; GO:0045886; GO:0004715; GO:0007424; GO:0004713; GO:0007435; GO:0007169; GO:0006099 "ATP binding; JNK cascade; actin filament bundle assembly; adherens junction; adherens junction organization; apoptotic cell clearance; compound eye development; dorsal closure, spreading of leading edge cells; epithelial cell-cell adhesion; imaginal disc fusion, thorax closure; imaginal disc-derived wing morphogenesis; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of synaptic growth at neuromuscular junction; non-membrane spanning protein tyrosine kinase activity; open tracheal system development; protein tyrosine kinase activity; salivary gland morphogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; tricarboxylic acid cycle" IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Tyrosine-protein kinase Src41) (Dsrc41) Src42A Src41 TK5 CG44128 Drosophila melanogaster (Fruit fly) TR39901_c1_g4_i1 P34109 MYOD_DICDI 6.00E-07 GO:0005524; GO:0005938; GO:0031252; GO:0006935; GO:0003774; GO:0016459; GO:0006909; GO:0031143 ATP binding; cell cortex; cell leading edge; chemotaxis; motor activity; myosin complex; phagocytosis; pseudopodium IPR001609; IPR010926; IPR027417; IPR001452; Myosin ID heavy chain myoD dmiD DDB_G0275447 Dictyostelium discoideum (Slime mold) TR39901_c1_g4_i2 Q6NU22 SH34A_XENLA 2.00E-08 GO:0005092; GO:0071230; GO:0030136; GO:0005905; GO:0005737; GO:0006897; GO:0034260; GO:0032007; GO:0030308; GO:0008285; GO:0005634; GO:0010508; GO:0061462 GDP-dissociation inhibitor activity; cellular response to amino acid stimulus; clathrin-coated vesicle; coated pit; cytoplasm; endocytosis; negative regulation of GTPase activity; negative regulation of TOR signaling cascade; negative regulation of cell growth; negative regulation of cell proliferation; nucleus; positive regulation of autophagy; protein localization to lysosome IPR011511; IPR001452; IPR000906; SH3 domain-binding protein 4-A sh3bp4-a Xenopus laevis (African clawed frog) TR39906_c1_g1_i1 Q01279 EGFR_MOUSE 2.00E-51 GO:0005524; GO:0000139; GO:0016323; GO:0000902; GO:0008283; GO:0016337; GO:0071392; GO:0021795; GO:0003682; GO:0048546; GO:0001892; GO:0030139; GO:0005789; GO:0005768; GO:0010008; GO:0005006; GO:0001942; GO:0016021; GO:0045121; GO:0060571; GO:0043066; GO:0042177; GO:0030235; GO:0031965; GO:0005634; GO:0048471; GO:0045739; GO:0045740; GO:0070374; GO:0043406; GO:0035413; GO:0030335; GO:0031659; GO:0050679; GO:0048146; GO:0045429; GO:0051897; GO:0001934; GO:0045944; GO:0046777; GO:0004716; GO:0050999; GO:0050730; GO:0070141; GO:0007435; GO:0023014 P01133; P32883 ATP binding; Golgi membrane; basolateral plasma membrane; cell morphogenesis; cell proliferation; cell-cell adhesion; cellular response to estradiol stimulus; cerebral cortex cell migration; chromatin binding; digestive tract morphogenesis; embryonic placenta development; endocytic vesicle; endoplasmic reticulum membrane; endosome; endosome membrane; epidermal growth factor-activated receptor activity; hair follicle development; integral to membrane; membrane raft; morphogenesis of an epithelial fold; negative regulation of apoptotic process; negative regulation of protein catabolic process; nitric-oxide synthase regulator activity; nuclear membrane; nucleus; perinuclear region of cytoplasm; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAP kinase activity; positive regulation of catenin import into nucleus; positive regulation of cell migration; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of nitric oxide biosynthetic process; positive regulation of protein kinase B signaling cascade; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein autophosphorylation; receptor signaling protein tyrosine kinase activity; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; response to UV-A; salivary gland morphogenesis; signal transduction by phosphorylation IPR000494; IPR006211; IPR006212; IPR009030; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR016245; Epidermal growth factor receptor (EC 2.7.10.1) Egfr Mus musculus (Mouse) TR39906_c1_g1_i2 Q06806 TIE1_MOUSE 5.00E-80 GO:0005524; GO:0001525; GO:0001701; GO:0016021; GO:0016525; GO:0030336; GO:0018108; GO:0005886; GO:0045026; GO:0032526; GO:0004714 ATP binding; angiogenesis; in utero embryonic development; integral to membrane; negative regulation of angiogenesis; negative regulation of cell migration; peptidyl-tyrosine phosphorylation; plasma membrane; plasma membrane fusion; response to retinoic acid; transmembrane receptor protein tyrosine kinase activity IPR000742; IPR013032; IPR003961; IPR007110; IPR013783; IPR003599; IPR013151; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) Tie1 Tie Tie-1 Mus musculus (Mouse) TR39906_c1_g1_i3 P04626 ERBB2_HUMAN 1.00E-47 GO:0005524; GO:0043125; GO:0038095; GO:0001042; GO:0016324; GO:0007411; GO:0016323; GO:0008283; GO:0010008; GO:0005006; GO:0008543; GO:0007507; GO:0045087; GO:0016021; GO:0030879; GO:0008045; GO:0042552; GO:0033088; GO:0007528; GO:0048011; GO:0005634; GO:0048471; GO:0007422; GO:0014065; GO:0043406; GO:0032321; GO:0045785; GO:0030307; GO:0050679; GO:0045943; GO:0045945; GO:0045727; GO:0046777; GO:0046982; GO:0043235; GO:0004716; GO:0070372; GO:0045765; GO:0032886; GO:0006351; GO:0042060 Itself; P00519; P42684; P15309; P60709; Q92625; O00213; O75815; Q9NSE2; Q7Z7G1; P46109; Q99704; Q8TEW6; Q15075; P98172; P00533; P21860; Q15303; P09769; P62993; Q14451; O75367; O75367-3; P08238; P46940; P35568; Q08881; P23458; Q14974; Q9UQF2; Q13387; P42679; Q9Y316; O43639; Q02297-7; O00750; P27986; O00459; Q92569; P19174; P16885; O95602; Q06124; Q05209; P23467; P08575; Q12913; Q15262; Q16827; P49792; P20936; O95980; Q9NP31; P29353; P98077; Q92529; Q9H6Q3; O15524; P12931; P42224; P40763; Q7KZ85; P43405; Q63HR2; Q9Y490; Q68CZ2; Q96D37; P52735; O14980 "ATP binding; ErbB-3 class receptor binding; Fc-epsilon receptor signaling pathway; RNA polymerase I core binding; apical plasma membrane; axon guidance; basolateral plasma membrane; cell proliferation; endosome membrane; epidermal growth factor-activated receptor activity; fibroblast growth factor receptor signaling pathway; heart development; innate immune response; integral to membrane; mammary gland development; motor neuron axon guidance; myelination; negative regulation of immature T cell proliferation in thymus; neuromuscular junction development; neurotrophin TRK receptor signaling pathway; nucleus; perinuclear region of cytoplasm; peripheral nervous system development; phosphatidylinositol 3-kinase cascade; positive regulation of MAP kinase activity; positive regulation of Rho GTPase activity; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of epithelial cell proliferation; positive regulation of transcription from RNA polymerase I promoter; positive regulation of transcription from RNA polymerase III promoter; positive regulation of translation; protein autophosphorylation; protein heterodimerization activity; receptor complex; receptor signaling protein tyrosine kinase activity; regulation of ERK1 and ERK2 cascade; regulation of angiogenesis; regulation of microtubule-based process; transcription, DNA-dependent; wound healing" IPR000494; IPR006211; IPR006212; IPR009030; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR016245; Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) ERBB2 HER2 MLN19 NEU NGL Homo sapiens (Human) TR39906_c1_g2_i1 Q5ND28 SREC_MOUSE 3.00E-22 GO:0007155; GO:0016358; GO:0016021; GO:0030169; GO:0016322; GO:0005886; GO:0048680; GO:0005044 cell adhesion; dendrite development; integral to membrane; low-density lipoprotein particle binding; neuron remodeling; plasma membrane; positive regulation of axon regeneration; scavenger receptor activity IPR000742; IPR013032; IPR002049; IPR009030; Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) TR39907_c1_g1_i4 Q9NPB8 GPCP1_HUMAN 6.00E-118 GO:0005829; GO:0006071; GO:0047389; GO:0008889; GO:0046474; GO:0044281; GO:2001070 cytosol; glycerol metabolic process; glycerophosphocholine phosphodiesterase activity; glycerophosphodiester phosphodiesterase activity; glycerophospholipid biosynthetic process; small molecule metabolic process; starch binding IPR013784; IPR002044; IPR004129; IPR013783; IPR017946; Glycerophosphocholine phosphodiesterase GPCPD1 (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 5) GPCPD1 GDE5 KIAA1434 Homo sapiens (Human) TR39907_c1_g1_i5 Q80VJ4 GPCP1_RAT 1.00E-09 GO:0005829; GO:0006071; GO:0047389; GO:0008889; GO:0006629; GO:2001070 cytosol; glycerol metabolic process; glycerophosphocholine phosphodiesterase activity; glycerophosphodiester phosphodiesterase activity; lipid metabolic process; starch binding IPR013784; IPR002044; IPR004129; IPR013783; IPR017946; Glycerophosphocholine phosphodiesterase GPCPD1 (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 5) Gpcpd1 Gde5 Rattus norvegicus (Rat) TR39910_c2_g2_i2 Q5MYT7 OAS3_RAT 2.00E-16 GO:0001730; GO:0005524; GO:0005737; GO:0051607; GO:0003725; GO:0045087; GO:0046872; GO:0005634; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; cytoplasm; defense response to virus; double-stranded RNA binding; innate immune response; metal ion binding; nucleus; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) Oas3 Rattus norvegicus (Rat) TR39910_c2_g2_i3 P00973 OAS1_HUMAN 5.00E-14 GO:0001730; GO:0005524; GO:0035457; GO:0005737; GO:0005829; GO:0051607; GO:0003725; GO:0005783; GO:0005576; GO:0060333; GO:0046872; GO:0005739; GO:0045071; GO:0005634; GO:0051259; GO:0006164; GO:0060700; GO:0009615; GO:0060337; GO:0008270 Q96LA8 2'-5'-oligoadenylate synthetase activity; ATP binding; cellular response to interferon-alpha; cytoplasm; cytosol; defense response to virus; double-stranded RNA binding; endoplasmic reticulum; extracellular region; interferon-gamma-mediated signaling pathway; metal ion binding; mitochondrion; negative regulation of viral genome replication; nucleus; protein oligomerization; purine nucleotide biosynthetic process; regulation of ribonuclease activity; response to virus; type I interferon-mediated signaling pathway; zinc ion binding IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 1 ((2-5')oligo(A) synthase 1) (2-5A synthase 1) (EC 2.7.7.84) (E18/E16) (p46/p42 OAS) OAS1 OIAS Homo sapiens (Human) TR39910_c2_g3_i1 Q9Y6K5 OAS3_HUMAN 2.00E-08 GO:0001730; GO:0005524; GO:0005829; GO:0051607; GO:0003725; GO:0060333; GO:0043231; GO:0046872; GO:0045071; GO:0006139; GO:0005634; GO:0060700; GO:0060337 Q7L2E3; P56537; Q8IY81; Q12894; Q7Z434 2'-5'-oligoadenylate synthetase activity; ATP binding; cytosol; defense response to virus; double-stranded RNA binding; interferon-gamma-mediated signaling pathway; intracellular membrane-bounded organelle; metal ion binding; negative regulation of viral genome replication; nucleobase-containing compound metabolic process; nucleus; regulation of ribonuclease activity; type I interferon-mediated signaling pathway IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (p100 OAS) (p100OAS) OAS3 P/OKcl.4 Homo sapiens (Human) TR39911_c0_g1_i2 Q17QM9 CNRP1_BOVIN 1.00E-15 CB1 cannabinoid receptor-interacting protein 1 (CRIP-1) CNRIP1 Bos taurus (Bovine) TR39911_c2_g1_i2 Q64663 P2RX7_RAT 1.00E-07 GO:0005524; GO:0043132; GO:0043029; GO:0042098; GO:0000187; GO:0097190; GO:0032059; GO:0032060; GO:0000902; GO:0006884; GO:0005911; GO:0031668; GO:0046513; GO:0032963; GO:0005507; GO:0019835; GO:0005737; GO:0050830; GO:0009897; GO:0004931; GO:0048873; GO:0006954; GO:0005639; GO:0005887; GO:0001530; GO:0000287; GO:0006900; GO:0051899; GO:0006509; GO:0045121; GO:0007005; GO:0044254; GO:0043409; GO:0045779; GO:0031594; GO:0043025; GO:0015695; GO:0001845; GO:0006649; GO:0045332; GO:0005886; GO:0007009; GO:0046931; GO:0001916; GO:0043065; GO:0030501; GO:0045919; GO:0051495; GO:0014054; GO:0014049; GO:0050717; GO:0050718; GO:0032755; GO:0051901; GO:0032308; GO:0043234; GO:0051259; GO:0006468; GO:0016485; GO:0043539; GO:0001614; GO:0072593; GO:0019228; GO:0002028; GO:0051209; GO:0033198; GO:0051592; GO:0042493; GO:0051602; GO:0034405; GO:0032496; GO:0009612; GO:0010043; GO:0019233; GO:0048705; GO:0016079; GO:0043195; GO:0008270 ATP binding; NAD transport; T cell homeostasis; T cell proliferation; activation of MAPK activity; apoptotic signaling pathway; bleb; bleb assembly; cell morphogenesis; cell volume homeostasis; cell-cell junction; cellular response to extracellular stimulus; ceramide biosynthetic process; collagen metabolic process; copper ion binding; cytolysis; cytoplasm; defense response to Gram-positive bacterium; external side of plasma membrane; extracellular ATP-gated cation channel activity; homeostasis of number of cells within a tissue; inflammatory response; integral to nuclear inner membrane; integral to plasma membrane; lipopolysaccharide binding; magnesium ion binding; membrane budding; membrane depolarization; membrane protein ectodomain proteolysis; membrane raft; mitochondrion organization; multicellular organismal protein catabolic process; negative regulation of MAPK cascade; negative regulation of bone resorption; neuromuscular junction; neuronal cell body; organic cation transport; phagolysosome assembly; phospholipid transfer to membrane; phospholipid translocation; plasma membrane; plasma membrane organization; pore complex assembly; positive regulation of T cell mediated cytotoxicity; positive regulation of apoptotic process; positive regulation of bone mineralization; positive regulation of cytolysis; positive regulation of cytoskeleton organization; positive regulation of gamma-aminobutyric acid secretion; positive regulation of glutamate secretion; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 production; positive regulation of mitochondrial depolarization; positive regulation of prostaglandin secretion; protein complex; protein oligomerization; protein phosphorylation; protein processing; protein serine/threonine kinase activator activity; purinergic nucleotide receptor activity; reactive oxygen species metabolic process; regulation of action potential in neuron; regulation of sodium ion transport; release of sequestered calcium ion into cytosol; response to ATP; response to calcium ion; response to drug; response to electrical stimulus; response to fluid shear stress; response to lipopolysaccharide; response to mechanical stimulus; response to zinc ion; sensory perception of pain; skeletal system morphogenesis; synaptic vesicle exocytosis; terminal bouton; zinc ion binding IPR003050; IPR027309; IPR001429; P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2rx7 Rattus norvegicus (Rat) TR39911_c3_g2_i2 O14730 RIOK3_HUMAN 1.00E-152 GO:0005524; GO:0007059; GO:0004674 Q92851 ATP binding; chromosome segregation; protein serine/threonine kinase activity IPR011009; IPR018934; IPR000687; IPR018935; IPR017406; Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3) (sudD homolog) RIOK3 SUDD Homo sapiens (Human) TR39912_c0_g1_i1 Q96MM6 HS12B_HUMAN 3.00E-08 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR39912_c0_g1_i3 O43301 HS12A_HUMAN 5.00E-13 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR39912_c1_g1_i1 Q96MM6 HS12B_HUMAN 1.00E-42 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR39912_c1_g2_i1 O43301 HS12A_HUMAN 6.00E-36 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR39913_c2_g1_i2 Q8BSU7 MOB3A_MOUSE 7.00E-07 GO:0005622; GO:0046872 intracellular; metal ion binding IPR005301; MOB kinase activator 3A (Mob1 homolog 2A) (Mps one binder kinase activator-like 2A) Mob3a Mobkl2a Mus musculus (Mouse) TR39913_c2_g1_i3 Q9QYW3 PHOCN_RAT 2.00E-130 GO:0005794; GO:0032580; GO:0016020; GO:0006900; GO:0046872 Golgi apparatus; Golgi cisterna membrane; membrane; membrane budding; metal ion binding IPR005301; MOB-like protein phocein (Class II mMOB1) (Mob1 homolog 3) (Mob3) (Mps one binder kinase activator-like 3) (Phocein) (Preimplantation protein 3) Mob4 Mob3 Mobkl1 Phocn Prei3 Rattus norvegicus (Rat) TR39914_c4_g1_i1 O18531 ECR_LUCCU 2.00E-34 GO:0004884; GO:0005634; GO:0043565; GO:0005496; GO:0008270 ecdysteroid hormone receptor activity; nucleus; sequence-specific DNA binding; steroid binding; zinc ion binding IPR003069; IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Ecdysone receptor (20-hydroxy-ecdysone receptor) (20E receptor) (EcRH) (Ecdysteroid receptor) (Nuclear receptor subfamily 1 group H member 1) EcR NR1H1 Lucilia cuprina (Green bottle fly) (Australian sheep blowfly) TR39916_c2_g2_i1 A6H584 CO6A5_MOUSE 5.00E-11 GO:0007155; GO:0005581; GO:0005576 cell adhesion; collagen; extracellular region IPR008160; IPR002035; Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) Col6a5 Col29a1 Gm7455 Mus musculus (Mouse) TR39916_c3_g1_i1 P49013 FBP3_STRPU 5.00E-90 GO:0005509; GO:0005615 calcium ion binding; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) TR39916_c3_g1_i2 P22457 FA7_BOVIN 4.00E-08 GO:0007596; GO:0005509; GO:0005576; GO:0002690; GO:0010641; GO:0050927; GO:0051897; GO:0006508; GO:0004252 blood coagulation; calcium ion binding; extracellular region; positive regulation of leukocyte chemotaxis; positive regulation of platelet-derived growth factor receptor signaling pathway; positive regulation of positive chemotaxis; positive regulation of protein kinase B signaling cascade; proteolysis; serine-type endopeptidase activity IPR017857; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR000294; IPR012224; IPR001254; IPR018114; IPR001314; IPR009003; Coagulation factor VII (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Cleaved into: Factor VII light chain; Factor VII heavy chain] F7 Bos taurus (Bovine) TR39916_c3_g1_i3 P10079 FBP1_STRPU 6.00E-101 GO:0032579; GO:0005509; GO:0016023; GO:0005615 apical lamina of hyaline layer; calcium ion binding; cytoplasmic membrane-bounded vesicle; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) TR39916_c4_g3_i2 Q9BDY8 ANGP1_PIG 6.00E-45 GO:0001525; GO:0030154; GO:0005576 angiogenesis; cell differentiation; extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-1 (ANG-1) ANGPT1 Sus scrofa (Pig) TR39916_c4_g3_i4 Q15485 FCN2_HUMAN 9.00E-59 GO:0003823; GO:0005509; GO:0030246; GO:0005581; GO:0001867; GO:0005576; GO:0008228 Q07954 "antigen binding; calcium ion binding; carbohydrate binding; collagen; complement activation, lectin pathway; extracellular region; opsonization" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-2 (37 kDa elastin-binding protein) (Collagen/fibrinogen domain-containing protein 2) (EBP-37) (Ficolin-B) (Ficolin-beta) (Hucolin) (L-ficolin) (Serum lectin p35) FCN2 FCNL Homo sapiens (Human) TR39916_c4_g3_i7 P12799 FIBG_BOVIN 1.00E-41 GO:0005577; GO:0030168; GO:0051258; GO:0007165 fibrinogen complex; platelet activation; protein polymerization; signal transduction IPR014716; IPR014715; IPR002181; IPR012290; IPR020837; Fibrinogen gamma-B chain (Gamma') FGG Bos taurus (Bovine) TR39917_c2_g1_i1 Q80U96 XPO1_RAT 5.00E-80 GO:0015030; GO:0003723; GO:0005642; GO:0005737; GO:0000776; GO:0051028; GO:0000122; GO:0005730; GO:0006611; GO:0042493; GO:0030529 Cajal body; RNA binding; annulate lamellae; cytoplasm; kinetochore; mRNA transport; negative regulation of transcription from RNA polymerase II promoter; nucleolus; protein export from nucleus; response to drug; ribonucleoprotein complex IPR011989; IPR016024; IPR014877; IPR013598; IPR001494; Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) Xpo1 Crm1 Rattus norvegicus (Rat) TR39917_c3_g2_i3 Q6P5F9 XPO1_MOUSE 0 GO:0015030; GO:0003723; GO:0005642; GO:0005737; GO:0000776; GO:0051028; GO:0000122; GO:0005730; GO:0005634; GO:0006611; GO:0034504; GO:0008565; GO:0010824; GO:0042176; GO:0046825; GO:0042493; GO:0030529 Cajal body; RNA binding; annulate lamellae; cytoplasm; kinetochore; mRNA transport; negative regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; protein export from nucleus; protein localization to nucleus; protein transporter activity; regulation of centrosome duplication; regulation of protein catabolic process; regulation of protein export from nucleus; response to drug; ribonucleoprotein complex IPR011989; IPR016024; IPR014877; IPR013598; IPR001494; Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) Xpo1 Crm1 Mus musculus (Mouse) TR39920_c2_g1_i1 Q32LQ6 MFSD1_DANRE 2.00E-155 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Major facilitator superfamily domain-containing protein 1 mfsd1 zgc:123187 Danio rerio (Zebrafish) (Brachydanio rerio) TR39921_c0_g1_i2 Q06546 GABPA_HUMAN 2.00E-126 GO:0000978; GO:0001228; GO:0003682; GO:0001701; GO:0045653; GO:0000122; GO:0000790; GO:0046982; GO:0003713 P51610 RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; chromatin binding; in utero embryonic development; negative regulation of megakaryocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; protein heterodimerization activity; transcription coactivator activity IPR000418; IPR024668; IPR003118; IPR013761; IPR016312; IPR011991; GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60) GABPA E4TF1A Homo sapiens (Human) TR39922_c1_g1_i1 Q05AM5 ELP2_DANRE 0 GO:0005737; GO:0061133; GO:0005634; GO:0043248; GO:0000502; GO:0006355; GO:0006368 "cytoplasm; endopeptidase activator activity; nucleus; proteasome assembly; proteasome complex; regulation of transcription, DNA-dependent; transcription elongation from RNA polymerase II promoter" IPR011048; IPR002350; IPR015943; IPR001680; IPR017986; Elongator complex protein 2 (ELP2) elp2 si:dkey-190l1.1 zgc:153559 Danio rerio (Zebrafish) (Brachydanio rerio) TR39922_c1_g1_i2 Q05AM5 ELP2_DANRE 3.00E-41 GO:0005737; GO:0061133; GO:0005634; GO:0043248; GO:0000502; GO:0006355; GO:0006368 "cytoplasm; endopeptidase activator activity; nucleus; proteasome assembly; proteasome complex; regulation of transcription, DNA-dependent; transcription elongation from RNA polymerase II promoter" IPR011048; IPR002350; IPR015943; IPR001680; IPR017986; Elongator complex protein 2 (ELP2) elp2 si:dkey-190l1.1 zgc:153559 Danio rerio (Zebrafish) (Brachydanio rerio) TR39923_c0_g2_i1 Q08462 ADCY2_HUMAN 4.00E-71 GO:0005524; GO:0007202; GO:0034199; GO:0004016; GO:0008179; GO:0007189; GO:0007193; GO:0008294; GO:0071377; GO:0005737; GO:0030425; GO:0006112; GO:0007173; GO:0008543; GO:0045087; GO:0016021; GO:0035556; GO:0045121; GO:0046872; GO:0048011; GO:0005886; GO:0043234; GO:0046982; GO:0007268; GO:0055085; GO:0006833 ATP binding; activation of phospholipase C activity; activation of protein kinase A activity; adenylate cyclase activity; adenylate cyclase binding; adenylate cyclase-activating G-protein coupled receptor signaling pathway; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; calcium- and calmodulin-responsive adenylate cyclase activity; cellular response to glucagon stimulus; cytoplasm; dendrite; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; integral to membrane; intracellular signal transduction; membrane raft; metal ion binding; neurotrophin TRK receptor signaling pathway; plasma membrane; protein complex; protein heterodimerization activity; synaptic transmission; transmembrane transport; water transport IPR001054; IPR018297; IPR009398; Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2) ADCY2 KIAA1060 Homo sapiens (Human) TR39923_c0_g2_i3 Q29450 ADCY7_BOVIN 1.00E-59 GO:0005524; GO:0004016; GO:0071361; GO:0016021; GO:0035556; GO:0046872; GO:0005886; GO:0030819 ATP binding; adenylate cyclase activity; cellular response to ethanol; integral to membrane; intracellular signal transduction; metal ion binding; plasma membrane; positive regulation of cAMP biosynthetic process IPR001054; IPR018297; IPR009398; Adenylate cyclase type 7 (EC 4.6.1.1) (ATP pyrophosphate-lyase 7) (Adenylate cyclase type VII) (Adenylyl cyclase 7) ADCY7 Bos taurus (Bovine) TR39923_c0_g2_i5 O43306 ADCY6_HUMAN 1.00E-58 GO:0005524; GO:0007202; GO:0034199; GO:0004016; GO:0007189; GO:0007193; GO:0071870; GO:0071377; GO:0071380; GO:0005929; GO:0007212; GO:0006112; GO:0007173; GO:0008543; GO:0045087; GO:0016021; GO:0035556; GO:0046872; GO:0048011; GO:0005886; GO:0019901; GO:0007268; GO:0055085; GO:0006833 ATP binding; activation of phospholipase C activity; activation of protein kinase A activity; adenylate cyclase activity; adenylate cyclase-activating G-protein coupled receptor signaling pathway; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; cellular response to catecholamine stimulus; cellular response to glucagon stimulus; cellular response to prostaglandin E stimulus; cilium; dopamine receptor signaling pathway; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; integral to membrane; intracellular signal transduction; metal ion binding; neurotrophin TRK receptor signaling pathway; plasma membrane; protein kinase binding; synaptic transmission; transmembrane transport; water transport IPR001054; IPR018297; IPR009398; Adenylate cyclase type 6 (EC 4.6.1.1) (ATP pyrophosphate-lyase 6) (Adenylate cyclase type VI) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) ADCY6 KIAA0422 Homo sapiens (Human) TR39923_c0_g3_i1 Q9VW60 ADCY2_DROME 3.00E-30 GO:0005524; GO:0004016; GO:0002165; GO:0016021; GO:0035556; GO:0046872; GO:0040015; GO:0042594 ATP binding; adenylate cyclase activity; instar larval or pupal development; integral to membrane; intracellular signal transduction; metal ion binding; negative regulation of multicellular organism growth; response to starvation IPR001054; IPR018297; Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 76E) Ac76E CG7978 Drosophila melanogaster (Fruit fly) TR39925_c0_g1_i1 Q8C8Y5 SAMD7_MOUSE 4.00E-12 IPR001660; IPR013761; IPR021129; Sterile alpha motif domain-containing protein 7 (SAM domain-containing protein 7) Samd7 Mus musculus (Mouse) TR39925_c0_g2_i2 Q24180 DEAF1_DROME 4.00E-13 GO:0009792; GO:0046872; GO:0005634; GO:0005700; GO:0045893; GO:0050776; GO:0006357; GO:0043565; GO:0003700; GO:0006351 "embryo development ending in birth or egg hatching; metal ion binding; nucleus; polytene chromosome; positive regulation of transcription, DNA-dependent; regulation of immune response; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000770; IPR010919; IPR024119; IPR002893; Deformed epidermal autoregulatory factor 1 (Protein DEAF-1) Deaf1 CG8567 Drosophila melanogaster (Fruit fly) TR39926_c0_g1_i1 Q7ZUS1 VRK1_DANRE 1.00E-21 GO:0005524; GO:0090166; GO:0005795; GO:0051301; GO:0007067; GO:0005634; GO:0004674 ATP binding; Golgi disassembly; Golgi stack; cell division; mitosis; nucleus; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) vrk1 zgc:56266 Danio rerio (Zebrafish) (Brachydanio rerio) TR39926_c0_g1_i2 Q8BK63 KC1A_MOUSE 0 GO:0005524; GO:0016055; GO:0051301; GO:0000902; GO:0000777; GO:0005737; GO:0005815; GO:0007067; GO:0016607; GO:0004674; GO:0030529 ATP binding; Wnt receptor signaling pathway; cell division; cell morphogenesis; condensed chromosome kinetochore; cytoplasm; microtubule organizing center; mitosis; nuclear speck; protein serine/threonine kinase activity; ribonucleoprotein complex IPR011009; IPR000719; IPR017441; IPR008271; Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) Csnk1a1 Mus musculus (Mouse) TR39931_c0_g1_i1 Q8IYB1 M21D2_HUMAN 4.00E-09 IPR024810; IPR024803; Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) TR39932_c0_g1_i1 Q9STQ6 SOT3_ARATH 4.00E-06 GO:0005737; GO:0008146 cytoplasm; sulfotransferase activity IPR027417; IPR000863; Cytosolic sulfotransferase 3 (AtSOT3) (EC 2.8.2.-) SOT3 At4g26280 T25K17.90 Arabidopsis thaliana (Mouse-ear cress) TR39932_c0_g2_i1 P50224 ST1A3_HUMAN 2.00E-29 GO:0050427; GO:0006987; GO:0004062; GO:0006584; GO:0044267; GO:0005829; GO:0009812; GO:0008202; GO:0051923; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; activation of signaling protein activity involved in unfolded protein response; aryl sulfotransferase activity; catecholamine metabolic process; cellular protein metabolic process; cytosol; flavonoid metabolic process; steroid metabolic process; sulfation; xenobiotic metabolic process IPR027417; IPR000863; "Sulfotransferase 1A3/1A4 (ST1A3/ST1A4) (EC 2.8.2.1) (Aryl sulfotransferase 1A3/1A4) (Catecholamine-sulfating phenol sulfotransferase) (HAST3) (M-PST) (Monoamine-sulfating phenol sulfotransferase) (Placental estrogen sulfotransferase) (Sulfotransferase, monoamine-preferring) (Thermolabile phenol sulfotransferase) (TL-PST)" SULT1A3 STM; SULT1A4 Homo sapiens (Human) TR39933_c0_g1_i3 Q9NVN3 RIC8B_HUMAN 3.00E-06 GO:0001965; GO:0005938; GO:0005813; GO:0005829; GO:0005085; GO:0005886; GO:0008277 G-protein alpha-subunit binding; cell cortex; centrosome; cytosol; guanyl-nucleotide exchange factor activity; plasma membrane; regulation of G-protein coupled receptor protein signaling pathway IPR011989; IPR016024; IPR019318; IPR008376; Synembryn-B (Brain synembryn) (hSyn) (Protein Ric-8B) RIC8B Homo sapiens (Human) TR39933_c0_g2_i2 Q61A92 RIC8_CAEBR 5.00E-39 GO:0005938; GO:0005085; GO:0007275 cell cortex; guanyl-nucleotide exchange factor activity; multicellular organismal development IPR019318; IPR008376; Synembryn (Resistance to inhibitors of cholinesterase protein 8) ric-8 CBG13878 Caenorhabditis briggsae TR39933_c0_g2_i3 Q642H7 RIC8A_DANRE 1.00E-79 GO:0005737; GO:0005085; GO:0005886 cytoplasm; guanyl-nucleotide exchange factor activity; plasma membrane IPR011989; IPR016024; IPR019318; IPR008376; Synembryn-A (Protein Ric-8A) ric8a zgc:92294 Danio rerio (Zebrafish) (Brachydanio rerio) TR39936_c0_g1_i10 O95257 GA45G_HUMAN 2.00E-19 GO:0006281; GO:0000186; GO:0000185; GO:0006915; GO:0030154; GO:0007275; GO:0006469; GO:0005634; GO:0051726 Q8TAE8; Q92993; Q9P2H0; Q9Y3C7; Q9BVJ6 DNA repair; activation of MAPKK activity; activation of MAPKKK activity; apoptotic process; cell differentiation; multicellular organismal development; negative regulation of protein kinase activity; nucleus; regulation of cell cycle IPR024824; IPR004038; Growth arrest and DNA damage-inducible protein GADD45 gamma (Cytokine-responsive protein CR6) (DNA damage-inducible transcript 2 protein) (DDIT-2) GADD45G CR6 DDIT2 Homo sapiens (Human) TR39936_c0_g1_i11 P24523 GA45A_CRIGR 5.00E-17 GO:0007050; GO:0005634; GO:0006974 cell cycle arrest; nucleus; response to DNA damage stimulus IPR024824; IPR004038; Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1) GADD45A DDIT1 GADD45 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR39936_c0_g1_i4 Q5E9A5 GA45B_BOVIN 2.00E-19 GO:0000186; GO:0006915; GO:0030154; GO:0007275; GO:0006469; GO:0005634; GO:0051726; GO:0006950 activation of MAPKK activity; apoptotic process; cell differentiation; multicellular organismal development; negative regulation of protein kinase activity; nucleus; regulation of cell cycle; response to stress IPR024824; IPR004038; Growth arrest and DNA damage-inducible protein GADD45 beta GADD45B Bos taurus (Bovine) TR39937_c0_g2_i1 P22128 RAB8_DISOM 1.00E-61 GO:0005525; GO:0005886; GO:0015031; GO:0007264 GTP binding; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-8 (ORA2) Diplobatis ommata (Ocellated electric ray) (Discopyge ommata) TR39937_c0_g2_i2 P25228 RAB3_DROME 1.00E-126 GO:0005525; GO:0030054; GO:0006887; GO:0048790; GO:0007269; GO:0048786; GO:0015031; GO:0007264; GO:0008021; GO:0016192 GTP binding; cell junction; exocytosis; maintenance of presynaptic active zone structure; neurotransmitter secretion; presynaptic active zone; protein transport; small GTPase mediated signal transduction; synaptic vesicle; vesicle-mediated transport IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-3 Rab3 CG7576 Drosophila melanogaster (Fruit fly) TR39937_c0_g2_i3 Q9JKM7 RAB37_MOUSE 2.00E-46 GO:0005525; GO:0003924; GO:0015031; GO:0030141; GO:0007264 GTP binding; GTPase activity; protein transport; secretory granule; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-37 Rab37 Mus musculus (Mouse) TR39939_c4_g1_i1 P97260 SCAP_CRIGR 5.00E-46 GO:0012507; GO:0000139; GO:0090110; GO:0008203; GO:0005789; GO:0072600; GO:0016021; GO:0035105 ER to Golgi transport vesicle membrane; Golgi membrane; cargo loading into COPII-coated vesicle; cholesterol metabolic process; endoplasmic reticulum membrane; establishment of protein localization to Golgi; integral to membrane; sterol regulatory element binding protein import into nucleus IPR000731; IPR015943; IPR001680; IPR019775; IPR017986; Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) SCAP Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR39939_c7_g1_i4 A6QM06 SCAP_BOVIN 8.00E-28 GO:0012507; GO:0000139; GO:0008203; GO:0005789; GO:0016021 ER to Golgi transport vesicle membrane; Golgi membrane; cholesterol metabolic process; endoplasmic reticulum membrane; integral to membrane IPR000731; IPR015943; IPR001680; IPR019775; IPR017986; Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) SCAP Bos taurus (Bovine) TR39939_c7_g1_i5 A2CEH0 POC1B_DANRE 1.00E-09 GO:0042384; GO:0060287; GO:0003014 cilium assembly; epithelial cilium movement involved in determination of left/right asymmetry; renal system process IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; POC1 centriolar protein homolog B (WD repeat domain 51B) poc1b tuwd12 wdr51b si:dkey-164B12.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR39939_c7_g2_i6 Q9NDC9 LIS1_CAEEL 4.00E-06 GO:0005818; GO:0005938; GO:0030154; GO:0051301; GO:0051026; GO:0000777; GO:0009792; GO:0043652; GO:0000132; GO:0000776; GO:0040011; GO:0005874; GO:0005875; GO:0005815; GO:0007018; GO:0007100; GO:0007399; GO:0048477; GO:0048471; GO:0035046; GO:0051225; GO:0051932; GO:0048489 "aster; cell cortex; cell differentiation; cell division; chiasma assembly; condensed chromosome kinetochore; embryo development ending in birth or egg hatching; engulfment of apoptotic cell; establishment of mitotic spindle orientation; kinetochore; locomotion; microtubule; microtubule associated complex; microtubule organizing center; microtubule-based movement; mitotic centrosome separation; nervous system development; oogenesis; perinuclear region of cytoplasm; pronuclear migration; spindle assembly; synaptic transmission, GABAergic; synaptic vesicle transport" IPR017252; IPR020472; IPR006594; IPR013720; IPR015943; IPR001680; IPR019775; IPR017986; Lissencephaly-1 homolog (Pronuclear migration abnormal protein 1) lis-1 pnm-1 T03F6.5 Caenorhabditis elegans TR39940_c0_g1_i1 P05182 CP2E1_RAT 1.00E-97 GO:0010181; GO:0000139; GO:0017144; GO:0020037; GO:0046483; GO:0031227; GO:0005506; GO:0005739; GO:0016098; GO:0016709; GO:0016712; GO:0042493; GO:0045471; GO:0010243; GO:0010193; GO:0008202; GO:0006641; GO:0006805 "FMN binding; Golgi membrane; drug metabolic process; heme binding; heterocycle metabolic process; intrinsic to endoplasmic reticulum membrane; iron ion binding; mitochondrion; monoterpenoid metabolic process; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; response to drug; response to ethanol; response to organonitrogen compound; response to ozone; steroid metabolic process; triglyceride metabolic process; xenobiotic metabolic process" IPR001128; IPR017972; IPR002401; IPR008070; Cytochrome P450 2E1 (EC 1.14.13.-) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) (Cytochrome P450RLM6) Cyp2e1 Cyp2e Cyp2e-1 Rattus norvegicus (Rat) TR39940_c0_g1_i2 Q29478 CP2CV_CAPAE 1.00E-36 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 2C31 (EC 1.14.14.1) (CYPIIC31) (Fragment) CYP2C31 Capra aegagrus (Wild goat) TR39940_c0_g1_i4 P55543 CPXR_RHISN 1.00E-08 GO:0020037; GO:0005506; GO:0004497; GO:0016705 "heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR002397; IPR017972; Cytochrome P450 BJ-3 homolog (EC 1.14.14.-) NGR_a02710 y4lC Rhizobium sp. (strain NGR234) TR39940_c0_g1_i5 P51590 CP2J3_RAT 1.00E-65 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; IPR008071; Cytochrome P450 2J3 (EC 1.14.14.1) (CYPIIJ3) Cyp2j3 Cyp2j9 Rattus norvegicus (Rat) TR39943_c6_g1_i1 P31689 DNJA1_HUMAN 3.00E-140 GO:0005524; GO:0030521; GO:0050750; GO:0016020; GO:0046872; GO:0006457; GO:0009408; GO:0006986; GO:0030317; GO:0007283 Q9GZX7 ATP binding; androgen receptor signaling pathway; low-density lipoprotein particle receptor binding; membrane; metal ion binding; protein folding; response to heat; response to unfolded protein; sperm motility; spermatogenesis IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) DNAJA1 DNAJ2 HDJ2 HSJ2 HSPF4 Homo sapiens (Human) TR39945_c1_g1_i2 Q13188 STK3_HUMAN 0 GO:0005524; GO:0006915; GO:0005829; GO:0035329; GO:0007243; GO:0000287; GO:0090090; GO:0005634; GO:0043065; GO:0046983; GO:0043539; GO:0004674 O95166; Q9H0R8; P60520; Q9GZQ8; Q9BXW4; Q9NS23-2; P50749; Q86WH2; Q9H2L5; Q8WWW0; Q9H4B6; Q14BN4; Q13043 ATP binding; apoptotic process; cytosol; hippo signaling cascade; intracellular protein kinase cascade; magnesium ion binding; negative regulation of canonical Wnt receptor signaling pathway; nucleus; positive regulation of apoptotic process; protein dimerization activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity IPR011009; IPR024205; IPR000719; IPR017441; IPR011524; IPR002290; Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] STK3 KRS1 MST2 Homo sapiens (Human) TR39946_c0_g1_i1 Q2T9U5 REXON_BOVIN 3.00E-39 GO:0003723; GO:0004527; GO:0090305; GO:0000166 RNA binding; exonuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleotide binding IPR006055; IPR013520; IPR012677; IPR012337; IPR000504; Putative RNA exonuclease NEF-sp (EC 3.1.-.-) Bos taurus (Bovine) TR39946_c0_g1_i2 A1A5R7 REXON_RAT 4.00E-38 GO:0003723; GO:0004527; GO:0090305; GO:0000166 RNA binding; exonuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleotide binding IPR006055; IPR013520; IPR012677; IPR012337; IPR000504; Putative RNA exonuclease NEF-sp (EC 3.1.-.-) Rattus norvegicus (Rat) TR39947_c0_g1_i1 O15460 P4HA2_HUMAN 3.00E-111 GO:0031418; GO:0009055; GO:0005788; GO:0005506; GO:0016702; GO:0018401; GO:0004656 "L-ascorbic acid binding; electron carrier activity; endoplasmic reticulum lumen; iron ion binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; procollagen-proline 4-dioxygenase activity" IPR005123; IPR006620; IPR013547; IPR013026; IPR011990; IPR019734; "Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2)" P4HA2 UNQ290/PRO330 Homo sapiens (Human) TR39947_c0_g1_i2 O15460 P4HA2_HUMAN 1.00E-136 GO:0031418; GO:0009055; GO:0005788; GO:0005506; GO:0016702; GO:0018401; GO:0004656 "L-ascorbic acid binding; electron carrier activity; endoplasmic reticulum lumen; iron ion binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; procollagen-proline 4-dioxygenase activity" IPR005123; IPR006620; IPR013547; IPR013026; IPR011990; IPR019734; "Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2)" P4HA2 UNQ290/PRO330 Homo sapiens (Human) TR39948_c1_g1_i1 Q28H54 CEPT1_XENTR 6.00E-140 GO:0006657; GO:0004142; GO:0005789; GO:0004307; GO:0016021; GO:0046872; GO:0031965; GO:0006646 CDP-choline pathway; diacylglycerol cholinephosphotransferase activity; endoplasmic reticulum membrane; ethanolaminephosphotransferase activity; integral to membrane; metal ion binding; nuclear membrane; phosphatidylethanolamine biosynthetic process IPR000462; IPR014472; Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3. Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2. Choline/ethanolaminephosphotransferase 1 (EC 2.7.8.1) (EC 2.7.8.2) cept1 TEgg057p14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR39948_c1_g1_i2 Q4KLV1 CHPT1_XENLA 5.00E-136 GO:0006657; GO:0000139; GO:0004142; GO:0016021; GO:0046872 CDP-choline pathway; Golgi membrane; diacylglycerol cholinephosphotransferase activity; integral to membrane; metal ion binding IPR000462; IPR014472; Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2. Cholinephosphotransferase 1 (EC 2.7.8.2) (Diacylglycerol cholinephosphotransferase 1) chpt1 Xenopus laevis (African clawed frog) TR39949_c2_g1_i1 Q29550 EST1_PIG 9.00E-46 GO:0004091; GO:0005788 carboxylesterase activity; endoplasmic reticulum lumen IPR002018; IPR019826; IPR019819; Liver carboxylesterase (EC 3.1.1.1) (Proline-beta-naphthylamidase) (Retinyl ester hydrolase) (REH) Sus scrofa (Pig) TR39949_c2_g1_i4 P12337 EST1_RABIT 9.00E-46 GO:0004091; GO:0005788 carboxylesterase activity; endoplasmic reticulum lumen IPR002018; IPR019826; IPR019819; Liver carboxylesterase 1 (EC 3.1.1.1) (Acyl-coenzyme A:cholesterol acyltransferase) Oryctolagus cuniculus (Rabbit) TR39950_c1_g1_i1 Q9C0Z4 DOP1_SCHPO 3.00E-28 GO:0000139; GO:0006895; GO:0007029; GO:0015031; GO:0008360 Golgi membrane; Golgi to endosome transport; endoplasmic reticulum organization; protein transport; regulation of cell shape IPR007249; Protein dopey SPAPB21F2.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR39950_c4_g1_i1 Q5JWR5 DOP1_HUMAN 2.00E-131 GO:0015031 protein transport IPR007249; Protein dopey-1 DOPEY1 KIAA1117 Homo sapiens (Human) TR39950_c4_g1_i4 Q5JWR5 DOP1_HUMAN 4.00E-133 GO:0015031 protein transport IPR007249; Protein dopey-1 DOPEY1 KIAA1117 Homo sapiens (Human) TR39950_c4_g1_i5 Q292H2 DOP1_DROPS 5.00E-116 GO:0015031 protein transport IPR007249; Protein dopey-1 homolog GA13490 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR39950_c4_g3_i1 Q5JWR5 DOP1_HUMAN 7.00E-107 GO:0015031 protein transport IPR007249; Protein dopey-1 DOPEY1 KIAA1117 Homo sapiens (Human) TR39953_c0_g1_i2 B5X3C1 GALC_SALSA 0 GO:0005975; GO:0004336; GO:0006683; GO:0005764 carbohydrate metabolic process; galactosylceramidase activity; galactosylceramide catabolic process; lysosome IPR001286; IPR013781; IPR017853; Galactocerebrosidase (GALCERase) (EC 3.2.1.46) (Galactosylceramidase) galc Salmo salar (Atlantic salmon) TR39953_c0_g1_i4 Q498K0 GALC_XENLA 0 GO:0005975; GO:0004336; GO:0006683; GO:0005764 carbohydrate metabolic process; galactosylceramidase activity; galactosylceramide catabolic process; lysosome IPR001286; IPR013781; IPR017853; Galactocerebrosidase (GALCERase) (EC 3.2.1.46) (Galactosylceramidase) galc Xenopus laevis (African clawed frog) TR39953_c0_g1_i5 Q498K0 GALC_XENLA 0 GO:0005975; GO:0004336; GO:0006683; GO:0005764 carbohydrate metabolic process; galactosylceramidase activity; galactosylceramide catabolic process; lysosome IPR001286; IPR013781; IPR017853; Galactocerebrosidase (GALCERase) (EC 3.2.1.46) (Galactosylceramidase) galc Xenopus laevis (African clawed frog) TR39954_c5_g3_i1 Q9UPN9 TRI33_HUMAN 7.00E-06 GO:0003677; GO:0030514; GO:0000122; GO:0005654; GO:0017015; GO:0006367; GO:0007179; GO:0004842; GO:0008270 Q15796; Q13485 DNA binding; negative regulation of BMP signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; regulation of transforming growth factor beta receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) TRIM33 KIAA1113 RFG7 TIF1G Homo sapiens (Human) TR39956_c2_g1_i2 Q868T3 CCAPR_DROME 1.00E-18 GO:0018990; GO:0005887; GO:0008188; GO:0005000 "ecdysis, chitin-based cuticle; integral to plasma membrane; neuropeptide receptor activity; vasopressin receptor activity" IPR000276; IPR017452; IPR001817; Cardioacceleratory peptide receptor CcapR CG6111 Drosophila melanogaster (Fruit fly) TR39956_c2_g1_i5 Q9TUP7 OX2R_CANFA 1.00E-07 GO:0022410; GO:0007631; GO:0016021; GO:0016499; GO:0007200; GO:0005886 circadian sleep/wake cycle process; feeding behavior; integral to membrane; orexin receptor activity; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane IPR000276; IPR017452; IPR000204; IPR004060; Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) HCRTR2 Canis familiaris (Dog) (Canis lupus familiaris) TR39956_c2_g1_i6 Q6W5P4 NPSR1_HUMAN 4.00E-14 GO:0005737; GO:0016021; GO:0008188; GO:0007218; GO:0005886; GO:0005000 cytoplasm; integral to membrane; neuropeptide receptor activity; neuropeptide signaling pathway; plasma membrane; vasopressin receptor activity IPR000276; IPR017452; IPR027294; IPR001817; Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) (G-protein coupled receptor for asthma susceptibility) NPSR1 GPR154 GPRA PGR14 Homo sapiens (Human) TR39956_c2_g1_i7 Q9WU02 V1BR_MOUSE 5.00E-14 GO:0016021; GO:0005886; GO:0001992; GO:0005000 integral to membrane; plasma membrane; regulation of systemic arterial blood pressure by vasopressin; vasopressin receptor activity IPR015076; IPR000276; IPR017452; IPR001817; IPR000628; Vasopressin V1b receptor (V1bR) (AVPR V1b) (AVPR V3) (Antidiuretic hormone receptor 1b) (Vasopressin V3 receptor) Avpr1b V1br Mus musculus (Mouse) TR39956_c2_g1_i8 P30559 OXYR_HUMAN 2.00E-07 GO:0070371; GO:0016324; GO:0005913; GO:0048565; GO:0042755; GO:0007204; GO:0060206; GO:0007565; GO:0007507; GO:0005887; GO:0007595; GO:0042711; GO:0060137; GO:0007613; GO:0005902; GO:0006936; GO:0060455; GO:0004990; GO:0017046; GO:0045777; GO:0010701; GO:0060406; GO:0051965; GO:0032230; GO:0051968; GO:0070474; GO:0001975; GO:0034059; GO:0042220; GO:0034097; GO:0042493; GO:0032355; GO:0043434; GO:0032570; GO:0030431; GO:0035176; GO:0042713; GO:0001967; GO:0021537; GO:0005000 "ERK1 and ERK2 cascade; apical plasma membrane; cell-cell adherens junction; digestive tract development; eating behavior; elevation of cytosolic calcium ion concentration; estrous cycle phase; female pregnancy; heart development; integral to plasma membrane; lactation; maternal behavior; maternal process involved in parturition; memory; microvillus; muscle contraction; negative regulation of gastric acid secretion; oxytocin receptor activity; peptide hormone binding; positive regulation of blood pressure; positive regulation of norepinephrine secretion; positive regulation of penile erection; positive regulation of synapse assembly; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; positive regulation of uterine smooth muscle contraction; response to amphetamine; response to anoxia; response to cocaine; response to cytokine stimulus; response to drug; response to estradiol stimulus; response to peptide hormone stimulus; response to progesterone stimulus; sleep; social behavior; sperm ejaculation; suckling behavior; telencephalon development; vasopressin receptor activity" IPR000276; IPR017452; IPR002062; IPR001817; Oxytocin receptor (OT-R) OXTR Homo sapiens (Human) TR39958_c0_g1_i1 B4PZ52 NFU1_DROYA 3.00E-98 GO:0005524; GO:0008026; GO:0005506; GO:0016226; GO:0051536; GO:0005739; GO:0003676 ATP binding; ATP-dependent helicase activity; iron ion binding; iron-sulfur cluster assembly; iron-sulfur cluster binding; mitochondrion; nucleic acid binding IPR017065; IPR014824; IPR001075; IPR000629; "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial" GE15286 Drosophila yakuba (Fruit fly) TR39958_c0_g1_i2 B4PZ52 NFU1_DROYA 5.00E-99 GO:0005524; GO:0008026; GO:0005506; GO:0016226; GO:0051536; GO:0005739; GO:0003676 ATP binding; ATP-dependent helicase activity; iron ion binding; iron-sulfur cluster assembly; iron-sulfur cluster binding; mitochondrion; nucleic acid binding IPR017065; IPR014824; IPR001075; IPR000629; "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial" GE15286 Drosophila yakuba (Fruit fly) TR39958_c0_g1_i3 Q49XP0 CVFC_STAS1 1.00E-07 GO:0005506 iron ion binding IPR011989; IPR016024; IPR014824; IPR004155; IPR025989; Conserved virulence factor C cvfC SSP1310 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) TR39958_c0_g1_i5 P32860 NFU1_YEAST 1.00E-37 GO:0006880; GO:0005506; GO:0016226; GO:0051536; GO:0005759 intracellular sequestering of iron ion; iron ion binding; iron-sulfur cluster assembly; iron-sulfur cluster binding; mitochondrial matrix IPR017065; IPR014824; IPR001075; "NifU-like protein, mitochondrial" NFU1 NUB1 YKL040C YKL253 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR39959_c0_g1_i1 P0CB49 YLPM1_RAT 4.00E-110 GO:0016607; GO:0006355; GO:0006351 "nuclear speck; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR027417; IPR026314; YLP motif-containing protein 1 (Nuclear protein ZAP3) Ylpm1 Zap Zap3 Rattus norvegicus (Rat) TR39961_c1_g3_i12 Q6R5N8 TLR13_MOUSE 6.00E-13 GO:0002755; GO:0005768; GO:0010008; GO:0006954; GO:0045087; GO:0016021; GO:0042803; GO:0019843; GO:0043408; GO:0002237; GO:0009615; GO:0034178; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; endosome; endosome membrane; inflammatory response; innate immune response; integral to membrane; protein homodimerization activity; rRNA binding; regulation of MAPK cascade; response to molecule of bacterial origin; response to virus; toll-like receptor 13 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR003591; IPR000157; IPR027196; Toll-like receptor 13 Tlr13 Mus musculus (Mouse) TR39961_c1_g3_i2 Q9BXR5 TLR10_HUMAN 2.00E-09 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0005886; GO:0050729; GO:0050707; GO:0034166; GO:0034146; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; plasma membrane; positive regulation of inflammatory response; regulation of cytokine secretion; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR000157; IPR027182; IPR017241; Toll-like receptor 10 (CD antigen CD290) TLR10 UNQ315/PRO358 Homo sapiens (Human) TR39961_c1_g3_i3 Q9QUN7 TLR2_MOUSE 1.00E-13 GO:0002755; GO:0035354; GO:0035355; GO:0002752; GO:0071221; GO:0071223; GO:0071224; GO:0042892; GO:0050830; GO:0042498; GO:0009897; GO:0052063; GO:0006954; GO:0045087; GO:0016021; GO:0070891; GO:0044130; GO:0032695; GO:0032700; GO:0030670; GO:0032722; GO:0050715; GO:0050729; GO:0032728; GO:0032735; GO:0032741; GO:0032755; GO:0002687; GO:0060907; GO:0045429; GO:0051770; GO:0045944; GO:0042535; GO:0032760; GO:0046982; GO:0002238; GO:0034134; GO:0004888; GO:0042497 MyD88-dependent toll-like receptor signaling pathway; Toll-like receptor 1-Toll-like receptor 2 protein complex; Toll-like receptor 2-Toll-like receptor 6 protein complex; cell surface pattern recognition receptor signaling pathway; cellular response to bacterial lipopeptide; cellular response to lipoteichoic acid; cellular response to peptidoglycan; chloramphenicol transport; defense response to Gram-positive bacterium; diacyl lipopeptide binding; external side of plasma membrane; induction by symbiont of defense-related host nitric oxide production; inflammatory response; innate immune response; integral to membrane; lipoteichoic acid binding; negative regulation of growth of symbiont in host; negative regulation of interleukin-12 production; negative regulation of interleukin-17 production; phagocytic vesicle membrane; positive regulation of chemokine production; positive regulation of cytokine secretion; positive regulation of inflammatory response; positive regulation of interferon-beta production; positive regulation of interleukin-12 production; positive regulation of interleukin-18 production; positive regulation of interleukin-6 production; positive regulation of leukocyte migration; positive regulation of macrophage cytokine production; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of tumor necrosis factor production; protein heterodimerization activity; response to molecule of fungal origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity; triacyl lipopeptide binding IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) Tlr2 Mus musculus (Mouse) TR39961_c1_g3_i7 Q704V6 TLR6_BOVIN 3.00E-13 GO:0002755; GO:0042088; GO:0042496; GO:0006954; GO:0045087; GO:0016021; GO:0030670; GO:0005886; GO:0045410; GO:0050707; GO:0034150; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; T-helper 1 type immune response; detection of diacyl bacterial lipopeptide; inflammatory response; innate immune response; integral to membrane; phagocytic vesicle membrane; plasma membrane; positive regulation of interleukin-6 biosynthetic process; regulation of cytokine secretion; toll-like receptor 6 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR000157; IPR027187; IPR017241; Toll-like receptor 6 (CD antigen CD286) TLR6 Bos taurus (Bovine) TR39962_c6_g1_i7 P08548 LIN1_NYCCO 1.00E-24 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR39962_c6_g1_i9 P08548 LIN1_NYCCO 1.00E-24 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR39963_c0_g1_i1 Q93X68 FABG5_BRANA 9.00E-36 GO:0004316; GO:0051287; GO:0009507; GO:0006633 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NAD binding; chloroplast; fatty acid biosynthetic process IPR011284; IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. "3-oxoacyl-[acyl-carrier-protein] reductase 5, chloroplastic (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase 5) (Fragment)" bkr1 Brassica napus (Rape) TR39963_c0_g1_i2 P51659 DHB4_HUMAN 0 GO:0044594; GO:0003857; GO:0033989; GO:0060009; GO:0036109; GO:0008209; GO:0006699; GO:0008210; GO:0033540; GO:0016853; GO:0016508; GO:0036112; GO:0005739; GO:0005782; GO:0005778; GO:0042803; GO:0032934; GO:0000038; GO:0036111 "17-beta-hydroxysteroid dehydrogenase (NAD+) activity; 3-hydroxyacyl-CoA dehydrogenase activity; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity; Sertoli cell development; alpha-linolenic acid metabolic process; androgen metabolic process; bile acid biosynthetic process; estrogen metabolic process; fatty acid beta-oxidation using acyl-CoA oxidase; isomerase activity; long-chain-enoyl-CoA hydratase activity; medium-chain fatty-acyl-CoA metabolic process; mitochondrion; peroxisomal matrix; peroxisomal membrane; protein homodimerization activity; sterol binding; very long-chain fatty acid metabolic process; very long-chain fatty-acyl-CoA metabolic process" IPR002198; IPR002347; IPR002539; IPR016040; IPR020904; IPR003033; Lipid metabolism; fatty acid beta-oxidation. "Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MPF-2) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]" HSD17B4 EDH17B4 Homo sapiens (Human) TR39963_c0_g1_i3 Q9X248 FABG_THEMA 9.00E-46 GO:0004316; GO:0051287; GO:0050661; GO:0030497 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NAD binding; NADP binding; fatty acid elongation IPR011284; IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) (Beta-Ketoacyl-acyl carrier protein reductase) (Beta-ketoacyl-ACP reductase) fabG TM_1724 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR39965_c1_g1_i1 P37454 EXOA_BACSU 8.00E-34 GO:0003677; GO:0006281; GO:0005737; GO:0004519; GO:0008853; GO:0046872; GO:0090305 DNA binding; DNA repair; cytoplasm; endonuclease activity; exodeoxyribonuclease III activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR004808; IPR020847; IPR020848; IPR005135; Exodeoxyribonuclease (EC 3.1.11.2) exoA BSU40880 Bacillus subtilis (strain 168) TR39965_c1_g1_i2 A0MTA1 APEX1_DANRE 9.00E-52 GO:0003677; GO:0080111; GO:0006281; GO:0003906; GO:0003723; GO:0004519; GO:0005783; GO:0060047; GO:0001947; GO:0046872; GO:0005739; GO:0043066; GO:0016607; GO:0090305; GO:0005730; GO:0010628 DNA binding; DNA demethylation; DNA repair; DNA-(apurinic or apyrimidinic site) lyase activity; RNA binding; endonuclease activity; endoplasmic reticulum; heart contraction; heart looping; metal ion binding; mitochondrion; negative regulation of apoptotic process; nuclear speck; nucleic acid phosphodiester bond hydrolysis; nucleolus; positive regulation of gene expression IPR004808; IPR020847; IPR020848; IPR005135; DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (zAP1) apex1 apex1a apex1b si:ch211-214j24.12 zgc:66204 Danio rerio (Zebrafish) (Brachydanio rerio) TR39965_c1_g2_i2 Q68G58 APEX2_MOUSE 1.00E-05 GO:0003677; GO:0006310; GO:0006281; GO:0003906; GO:0007049; GO:0004519; GO:0004527; GO:0005743; GO:0090305; GO:0005634; GO:0008270 DNA binding; DNA recombination; DNA repair; DNA-(apurinic or apyrimidinic site) lyase activity; cell cycle; endonuclease activity; exonuclease activity; mitochondrial inner membrane; nucleic acid phosphodiester bond hydrolysis; nucleus; zinc ion binding IPR004808; IPR020847; IPR005135; IPR010666; DNA-(apurinic or apyrimidinic site) lyase 2 (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2) Apex2 Ape2 Mus musculus (Mouse) TR39966_c1_g1_i1 Q09835 GOS1_SCHPO 1.00E-09 GO:0006888; GO:0005794; GO:0000139; GO:0005484; GO:0005801; GO:0016021; GO:0006886 ER to Golgi vesicle-mediated transport; Golgi apparatus; Golgi membrane; SNAP receptor activity; cis-Golgi network; integral to membrane; intracellular protein transport IPR023601; Protein transport protein gos1 (Golgi SNAP receptor complex member 1) (Golgi SNARE protein 1) gos1 SPAC4G8.10 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR39966_c1_g1_i2 O22151 GOS12_ARATH 1.00E-45 GO:0006888; GO:0000139; GO:0005801; GO:0005789; GO:0016021; GO:0015031 ER to Golgi vesicle-mediated transport; Golgi membrane; cis-Golgi network; endoplasmic reticulum membrane; integral to membrane; protein transport IPR023601; Golgi SNAP receptor complex member 1-2 (Golgi SNARE 12 protein) (AtGOS12) GOS12 At2g45200 F4L23.29 Arabidopsis thaliana (Mouse-ear cress) TR39966_c1_g1_i3 O88630 GOSR1_MOUSE 3.00E-108 GO:0006888; GO:0000139; GO:0005801; GO:0016021; GO:0015031; GO:0042147 "ER to Golgi vesicle-mediated transport; Golgi membrane; cis-Golgi network; integral to membrane; protein transport; retrograde transport, endosome to Golgi" IPR023601; Golgi SNAP receptor complex member 1 (28 kDa Golgi SNARE protein) (28 kDa cis-Golgi SNARE p28) (GOS-28) Gosr1 Gs28 Mus musculus (Mouse) TR39966_c1_g1_i5 Q9VE50 GOSR1_DROME 4.00E-62 GO:0006888; GO:0000139; GO:0000138; GO:0005484; GO:0005801; GO:0016021; GO:0006891; GO:0015031 ER to Golgi vesicle-mediated transport; Golgi membrane; Golgi trans cisterna; SNAP receptor activity; cis-Golgi network; integral to membrane; intra-Golgi vesicle-mediated transport; protein transport IPR023601; Golgi SNAP receptor complex member 1 (Probable 28 kDa Golgi SNARE protein) Gos28 CG7700 Drosophila melanogaster (Fruit fly) TR39967_c1_g1_i1 Q8NHP8 PLBL2_HUMAN 3.00E-179 GO:0016787; GO:0016042; GO:0043202 hydrolase activity; lipid catabolic process; lysosomal lumen IPR007000; Putative phospholipase B-like 2 (EC 3.1.1.-) (76 kDa protein) (p76) (LAMA-like protein 2) (Lamina ancestor homolog 2) (Phospholipase B domain-containing protein 2) [Cleaved into: Putative phospholipase B-like 2 32 kDa form; Putative phospholipase B-like 2 45 kDa form] PLBD2 Homo sapiens (Human) TR39971_c0_g1_i1 Q8Q0J4 PYRE_METMA 3.00E-26 GO:0044205; GO:0000287; GO:0004588 'de novo' UMP biosynthetic process; magnesium ion binding; orotate phosphoribosyltransferase activity IPR023031; IPR004467; IPR000836; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10) pyrE MM_0142 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR39971_c0_g1_i2 P13439 UMPS_MOUSE 7.00E-160 GO:0044205; GO:0006207; GO:0005737; GO:0005634; GO:0004588; GO:0004590 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; cytoplasm; nucleus; orotate phosphoribosyltransferase activity; orotidine-5'-phosphate decarboxylase activity IPR013785; IPR014732; IPR018089; IPR001754; IPR023031; IPR004467; IPR000836; IPR011060; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMPdecase)] Umps Mus musculus (Mouse) TR39971_c0_g1_i5 Q6BY69 PYRF_DEBHA 3.00E-73 GO:0044205; GO:0006207; GO:0004590 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; orotidine-5'-phosphate decarboxylase activity IPR013785; IPR014732; IPR018089; IPR001754; IPR011060; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMP decarboxylase) (OMPDCase) (OMPdecase) (Uridine 5'-monophosphate synthase) (UMP synthase) URA3 DEHA2A11968g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR39971_c0_g1_i6 P13439 UMPS_MOUSE 3.00E-154 GO:0044205; GO:0006207; GO:0005737; GO:0005634; GO:0004588; GO:0004590 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; cytoplasm; nucleus; orotate phosphoribosyltransferase activity; orotidine-5'-phosphate decarboxylase activity IPR013785; IPR014732; IPR018089; IPR001754; IPR023031; IPR004467; IPR000836; IPR011060; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMPdecase)] Umps Mus musculus (Mouse) TR39973_c5_g2_i5 Q6NWH0 CK068_DANRE 7.00E-23 IPR015034; IPR023398; UPF0696 protein C11orf68 homolog P5436 zgc:63470 Danio rerio (Zebrafish) (Brachydanio rerio) TR39974_c0_g3_i1 Q8NFW1 COMA1_HUMAN 2.00E-27 GO:0005581; GO:0005788; GO:0030198; GO:0005576 collagen; endoplasmic reticulum lumen; extracellular matrix organization; extracellular region IPR008160; IPR008985; IPR001791; IPR002035; Collagen alpha-1(XXII) chain COL22A1 Homo sapiens (Human) TR39974_c0_g3_i2 A2AX52 CO6A4_MOUSE 2.00E-24 GO:0007155; GO:0005581; GO:0005576; GO:0043234; GO:0070208 cell adhesion; collagen; extracellular region; protein complex; protein heterotrimerization IPR008160; IPR002035; Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) TR39974_c0_g3_i3 Q923P0 COKA1_MOUSE 1.00E-21 GO:0005581; GO:0005615 collagen; extracellular space IPR008160; IPR008985; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XX) chain Col20a1 Mus musculus (Mouse) TR39974_c0_g3_i4 Q8NFW1 COMA1_HUMAN 2.00E-27 GO:0005581; GO:0005788; GO:0030198; GO:0005576 collagen; endoplasmic reticulum lumen; extracellular matrix organization; extracellular region IPR008160; IPR008985; IPR001791; IPR002035; Collagen alpha-1(XXII) chain COL22A1 Homo sapiens (Human) TR39975_c0_g1_i2 P42345 MTOR_HUMAN 0 GO:0005524; GO:0038095; GO:0000139; GO:0016605; GO:0001030; GO:0001031; GO:0001032; GO:0031295; GO:0001156; GO:0031929; GO:0031931; GO:0031932; GO:0016049; GO:0071456; GO:0031669; GO:0008144; GO:0012505; GO:0005789; GO:0007173; GO:0008543; GO:0007281; GO:0045087; GO:0008286; GO:0005765; GO:0070438; GO:0005741; GO:0051534; GO:0010507; GO:0045792; GO:0016242; GO:0048011; GO:0018105; GO:0018107; GO:0005942; GO:0048015; GO:0030838; GO:0001938; GO:0010592; GO:0046889; GO:0010831; GO:0050731; GO:0051897; GO:0001934; GO:0051496; GO:0045945; GO:0045727; GO:0046777; GO:0030163; GO:0004674; GO:0032314; GO:0032956; GO:0043610; GO:0031998; GO:0005979; GO:0045859; GO:0032095; GO:0043200; GO:0007584; GO:0043022; GO:0031529 Q8TB45; Q13541; Q9BVC4; Q8TCU6; Q6R327; Q8N122; Q96EB6; Q8NHX9 ATP binding; Fc-epsilon receptor signaling pathway; Golgi membrane; PML body; RNA polymerase III type 1 promoter DNA binding; RNA polymerase III type 2 promoter DNA binding; RNA polymerase III type 3 promoter DNA binding; T cell costimulation; TFIIIC-class transcription factor binding; TOR signaling cascade; TORC1 complex; TORC2 complex; cell growth; cellular response to hypoxia; cellular response to nutrient levels; drug binding; endomembrane system; endoplasmic reticulum membrane; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; germ cell development; innate immune response; insulin receptor signaling pathway; lysosomal membrane; mTOR-FKBP12-rapamycin complex; mitochondrial outer membrane; negative regulation of NFAT protein import into nucleus; negative regulation of autophagy; negative regulation of cell size; negative regulation of macroautophagy; neurotrophin TRK receptor signaling pathway; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphatidylinositol 3-kinase complex; phosphatidylinositol-mediated signaling; positive regulation of actin filament polymerization; positive regulation of endothelial cell proliferation; positive regulation of lamellipodium assembly; positive regulation of lipid biosynthetic process; positive regulation of myotube differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; positive regulation of transcription from RNA polymerase III promoter; positive regulation of translation; protein autophosphorylation; protein catabolic process; protein serine/threonine kinase activity; regulation of Rac GTPase activity; regulation of actin cytoskeleton organization; regulation of carbohydrate utilization; regulation of fatty acid beta-oxidation; regulation of glycogen biosynthetic process; regulation of protein kinase activity; regulation of response to food; response to amino acid stimulus; response to nutrient; ribosome binding; ruffle organization IPR011989; IPR016024; IPR024585; IPR003152; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR009076; IPR026683; IPR011990; Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 Homo sapiens (Human) TR39975_c0_g1_i3 P42346 MTOR_RAT 4.00E-80 GO:0005524; GO:0000082; GO:0000139; GO:0016605; GO:0001030; GO:0001031; GO:0001032; GO:0031929; GO:0031931; GO:0031932; GO:0030030; GO:0071456; GO:0031669; GO:0005829; GO:0008144; GO:0005789; GO:0007281; GO:0005764; GO:0070438; GO:0005741; GO:0051534; GO:0010507; GO:0045792; GO:0016242; GO:0005634; GO:0018105; GO:0018107; GO:0030838; GO:0001938; GO:0010592; GO:0046889; GO:0010831; GO:0050731; GO:0051897; GO:0051496; GO:0045945; GO:0045727; GO:0046777; GO:0004674; GO:0032314; GO:0043610; GO:0031998; GO:0005979; GO:0045859; GO:0032095; GO:0043200; GO:0032868; GO:0043022; GO:0031529 Q8TB45 ATP binding; G1/S transition of mitotic cell cycle; Golgi membrane; PML body; RNA polymerase III type 1 promoter DNA binding; RNA polymerase III type 2 promoter DNA binding; RNA polymerase III type 3 promoter DNA binding; TOR signaling cascade; TORC1 complex; TORC2 complex; cell projection organization; cellular response to hypoxia; cellular response to nutrient levels; cytosol; drug binding; endoplasmic reticulum membrane; germ cell development; lysosome; mTOR-FKBP12-rapamycin complex; mitochondrial outer membrane; negative regulation of NFAT protein import into nucleus; negative regulation of autophagy; negative regulation of cell size; negative regulation of macroautophagy; nucleus; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of actin filament polymerization; positive regulation of endothelial cell proliferation; positive regulation of lamellipodium assembly; positive regulation of lipid biosynthetic process; positive regulation of myotube differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of stress fiber assembly; positive regulation of transcription from RNA polymerase III promoter; positive regulation of translation; protein autophosphorylation; protein serine/threonine kinase activity; regulation of Rac GTPase activity; regulation of carbohydrate utilization; regulation of fatty acid beta-oxidation; regulation of glycogen biosynthetic process; regulation of protein kinase activity; regulation of response to food; response to amino acid stimulus; response to insulin stimulus; ribosome binding; ruffle organization IPR011989; IPR016024; IPR024585; IPR003152; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR009076; IPR026683; IPR011990; Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin target protein 1) (RAPT1) Mtor Frap1 Raft1 Rattus norvegicus (Rat) TR39977_c1_g2_i1 O70531 S26A2_RAT 8.00E-28 GO:0016021; GO:0001503; GO:0008271; GO:0015116; GO:0008272 integral to membrane; ossification; secondary active sulfate transmembrane transporter activity; sulfate transmembrane transporter activity; sulfate transport IPR018045; IPR002645; IPR001902; IPR011547; Sulfate transporter (Diastrophic dysplasia protein homolog) (Solute carrier family 26 member 2) Slc26a2 Dtdst Rattus norvegicus (Rat) TR39977_c1_g2_i2 Q8NG04 S2610_HUMAN 2.00E-60 GO:0015297; GO:0016021; GO:0015116; GO:0008272 antiporter activity; integral to membrane; sulfate transmembrane transporter activity; sulfate transport IPR002645; IPR011547; Solute carrier family 26 member 10 SLC26A10 Homo sapiens (Human) TR39977_c1_g2_i3 O70531 S26A2_RAT 6.00E-105 GO:0016021; GO:0001503; GO:0008271; GO:0015116; GO:0008272 integral to membrane; ossification; secondary active sulfate transmembrane transporter activity; sulfate transmembrane transporter activity; sulfate transport IPR018045; IPR002645; IPR001902; IPR011547; Sulfate transporter (Diastrophic dysplasia protein homolog) (Solute carrier family 26 member 2) Slc26a2 Dtdst Rattus norvegicus (Rat) TR39978_c0_g1_i1 Q17389 CUL1_CAEEL 6.00E-85 GO:0007049; GO:0051301; GO:0031461; GO:0005737; GO:0009792; GO:0043066; GO:0008285; GO:0045930; GO:0002119; GO:0016567; GO:0008361; GO:0000003; GO:0006511 cell cycle; cell division; cullin-RING ubiquitin ligase complex; cytoplasm; embryo development ending in birth or egg hatching; negative regulation of apoptotic process; negative regulation of cell proliferation; negative regulation of mitotic cell cycle; nematode larval development; protein ubiquitination; regulation of cell size; reproduction; ubiquitin-dependent protein catabolic process IPR016157; IPR016158; IPR001373; IPR019559; IPR016159; IPR011991; Protein modification; protein ubiquitination. Cullin-1 (CUL-1) (Abnormal cell lineage protein 19) cul-1 lin-19 D2045.6 Caenorhabditis elegans TR39978_c0_g1_i2 Q6DE95 CUL3A_XENLA 0 GO:0048208; GO:0031463; GO:0016477; GO:0000910; GO:0040016; GO:0007229; GO:0000090; GO:0035024; GO:0005634; GO:0005827; GO:0043161; GO:0006513; GO:0017145; GO:0043149 COPII vesicle coating; Cul3-RING ubiquitin ligase complex; cell migration; cytokinesis; embryonic cleavage; integrin-mediated signaling pathway; mitotic anaphase; negative regulation of Rho protein signal transduction; nucleus; polar microtubule; proteasomal ubiquitin-dependent protein catabolic process; protein monoubiquitination; stem cell division; stress fiber assembly IPR016157; IPR016158; IPR001373; IPR019559; IPR016159; IPR011991; Protein modification; protein ubiquitination. Cullin-3-A (CUL-3-A) cul3a Xenopus laevis (African clawed frog) TR39978_c0_g1_i3 Q9ZVH4 CUL3A_ARATH 0 GO:0031461; GO:0005829; GO:0009793; GO:0009960; GO:0009911; GO:0009639; GO:0006511 Q9XHZ8; Q8L765; O22286; P93002; Q940X7 cullin-RING ubiquitin ligase complex; cytosol; embryo development ending in seed dormancy; endosperm development; positive regulation of flower development; response to red or far red light; ubiquitin-dependent protein catabolic process IPR016158; IPR001373; IPR019559; IPR016159; IPR011991; Cullin-3A (AtCUL3a) CUL3A CUL3 At1g26830 T2P11.2 Arabidopsis thaliana (Mouse-ear cress) TR39978_c0_g1_i4 Q9C9L0 CUL3B_ARATH 0 GO:0031461; GO:0009793; GO:0009960; GO:0016567; GO:0006511 Q8L765; Q940X7 cullin-RING ubiquitin ligase complex; embryo development ending in seed dormancy; endosperm development; protein ubiquitination; ubiquitin-dependent protein catabolic process IPR016158; IPR001373; IPR019559; IPR016159; IPR011991; Protein modification; protein ubiquitination. Cullin-3B (AtCUL3b) CUL3B At1g69670 T6C23.13 Arabidopsis thaliana (Mouse-ear cress) TR39978_c0_g1_i5 Q6DE95 CUL3A_XENLA 0 GO:0048208; GO:0031463; GO:0016477; GO:0000910; GO:0040016; GO:0007229; GO:0000090; GO:0035024; GO:0005634; GO:0005827; GO:0043161; GO:0006513; GO:0017145; GO:0043149 COPII vesicle coating; Cul3-RING ubiquitin ligase complex; cell migration; cytokinesis; embryonic cleavage; integrin-mediated signaling pathway; mitotic anaphase; negative regulation of Rho protein signal transduction; nucleus; polar microtubule; proteasomal ubiquitin-dependent protein catabolic process; protein monoubiquitination; stem cell division; stress fiber assembly IPR016157; IPR016158; IPR001373; IPR019559; IPR016159; IPR011991; Protein modification; protein ubiquitination. Cullin-3-A (CUL-3-A) cul3a Xenopus laevis (African clawed frog) TR39978_c0_g1_i7 Q6DE95 CUL3A_XENLA 0 GO:0048208; GO:0031463; GO:0016477; GO:0000910; GO:0040016; GO:0007229; GO:0000090; GO:0035024; GO:0005634; GO:0005827; GO:0043161; GO:0006513; GO:0017145; GO:0043149 COPII vesicle coating; Cul3-RING ubiquitin ligase complex; cell migration; cytokinesis; embryonic cleavage; integrin-mediated signaling pathway; mitotic anaphase; negative regulation of Rho protein signal transduction; nucleus; polar microtubule; proteasomal ubiquitin-dependent protein catabolic process; protein monoubiquitination; stem cell division; stress fiber assembly IPR016157; IPR016158; IPR001373; IPR019559; IPR016159; IPR011991; Protein modification; protein ubiquitination. Cullin-3-A (CUL-3-A) cul3a Xenopus laevis (African clawed frog) TR39979_c0_g1_i3 Q6ZVD7 STOX1_HUMAN 5.00E-29 GO:0003677; GO:0005737; GO:0005634 DNA binding; cytoplasm; nucleus IPR019391; Storkhead-box protein 1 (Winged-helix domain-containing protein) STOX1 C10orf24 Homo sapiens (Human) TR39979_c0_g1_i5 Q6ZVD7 STOX1_HUMAN 1.00E-26 GO:0003677; GO:0005737; GO:0005634 DNA binding; cytoplasm; nucleus IPR019391; Storkhead-box protein 1 (Winged-helix domain-containing protein) STOX1 C10orf24 Homo sapiens (Human) TR3998_c0_g1_i1 Q7TN88 PK1L2_MOUSE 2.00E-20 GO:0005262; GO:0005509; GO:0030246; GO:0050982; GO:0016021; GO:0016020; GO:0007218 calcium channel activity; calcium ion binding; carbohydrate binding; detection of mechanical stimulus; integral to membrane; membrane; neuropeptide signaling pathway IPR001304; IPR016186; IPR016187; IPR000203; IPR000922; IPR008976; IPR022409; IPR002859; IPR013122; IPR003915; IPR000601; IPR001024; IPR014010; Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) Pkd1l2 Mus musculus (Mouse) TR39980_c2_g1_i1 P43004 EAA2_HUMAN 3.00E-86 GO:0070779; GO:0051938; GO:0005313; GO:0030534; GO:0030673; GO:0031668; GO:0015501; GO:0016021; GO:0035264; GO:0010259; GO:0005886; GO:0046326; GO:0043200; GO:0042493; GO:0009611; GO:0017153; GO:0007268; GO:0021537; GO:0007632 P10636 D-aspartate import; L-glutamate import; L-glutamate transmembrane transporter activity; adult behavior; axolemma; cellular response to extracellular stimulus; glutamate:sodium symporter activity; integral to membrane; multicellular organism growth; multicellular organismal aging; plasma membrane; positive regulation of glucose import; response to amino acid stimulus; response to drug; response to wounding; sodium:dicarboxylate symporter activity; synaptic transmission; telencephalon development; visual behavior IPR001991; IPR018107; Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2) SLC1A2 EAAT2 GLT1 Homo sapiens (Human) TR39980_c2_g1_i2 O07605 GLTT_BACSU 8.00E-18 GO:0016021; GO:0005886; GO:0017153 integral to membrane; plasma membrane; sodium:dicarboxylate symporter activity IPR001991; IPR018107; Proton/sodium-glutamate symport protein (Glutamate-aspartate carrier protein) gltT yhfG BSU10220 Bacillus subtilis (strain 168) TR39980_c2_g1_i3 Q10901 EAA1_CAEEL 1.00E-94 GO:0005313; GO:0042995; GO:0016021; GO:0005886; GO:0017153 L-glutamate transmembrane transporter activity; cell projection; integral to membrane; plasma membrane; sodium:dicarboxylate symporter activity IPR001991; IPR018107; Excitatory amino acid transporter (Sodium-dependent glutamate/ aspartate transporter) glt-1 C12D12.2 Caenorhabditis elegans TR39980_c2_g1_i4 Q10901 EAA1_CAEEL 2.00E-94 GO:0005313; GO:0042995; GO:0016021; GO:0005886; GO:0017153 L-glutamate transmembrane transporter activity; cell projection; integral to membrane; plasma membrane; sodium:dicarboxylate symporter activity IPR001991; IPR018107; Excitatory amino acid transporter (Sodium-dependent glutamate/ aspartate transporter) glt-1 C12D12.2 Caenorhabditis elegans TR39980_c2_g2_i1 Q9I900 PA2AD_NAJSP 2.00E-09 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Acidic phospholipase A2 D (svPLA2) (EC 3.1.1.4) (APLA) (Phosphatidylcholine 2-acylhydrolase) Naja sputatrix (Malayan spitting cobra) (Naja naja sputatrix) TR39980_c2_g2_i2 Q6T179 PA2A4_NAJSG 2.00E-10 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Acidic phospholipase A2 4 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (Fragment) Naja sagittifera (Andaman cobra) TR39981_c3_g1_i1 Q505D1 ANR28_MOUSE 2.00E-11 GO:0005654 nucleoplasm IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) Ankrd28 Mus musculus (Mouse) TR39981_c3_g1_i2 Q91ZU0 ASB7_MOUSE 3.00E-17 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 7 (ASB-7) Asb7 Mus musculus (Mouse) TR39983_c1_g2_i2 O94813 SLIT2_HUMAN 4.00E-09 GO:0005095; GO:0035385; GO:0061364; GO:0048846; GO:0048754; GO:0005509; GO:0002042; GO:0009986; GO:0016337; GO:0071504; GO:0032870; GO:0045499; GO:0021836; GO:0021972; GO:0005737; GO:0033563; GO:0005615; GO:0008201; GO:0001701; GO:0050929; GO:0043237; GO:0060763; GO:0001656; GO:0008045; GO:0030837; GO:0030308; GO:0008285; GO:0090288; GO:0070100; GO:0010596; GO:0010629; GO:0010593; GO:0090027; GO:0071676; GO:0090024; GO:0001933; GO:0090260; GO:0051058; GO:0071672; GO:0043116; GO:0005886; GO:0043065; GO:0050772; GO:0042803; GO:0051414; GO:0031290; GO:0001657 Itself GTPase inhibitor activity; Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; branching morphogenesis of an epithelial tube; calcium ion binding; cell migration involved in sprouting angiogenesis; cell surface; cell-cell adhesion; cellular response to heparin; cellular response to hormone stimulus; chemorepellent activity; chemorepulsion involved in postnatal olfactory bulb interneuron migration; corticospinal neuron axon guidance through spinal cord; cytoplasm; dorsal/ventral axon guidance; extracellular space; heparin binding; in utero embryonic development; induction of negative chemotaxis; laminin-1 binding; mammary duct terminal end bud growth; metanephros development; motor neuron axon guidance; negative regulation of actin filament polymerization; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cellular response to growth factor stimulus; negative regulation of chemokine-mediated signaling pathway; negative regulation of endothelial cell migration; negative regulation of gene expression; negative regulation of lamellipodium assembly; negative regulation of monocyte chemotaxis; negative regulation of mononuclear cell migration; negative regulation of neutrophil chemotaxis; negative regulation of protein phosphorylation; negative regulation of retinal ganglion cell axon guidance; negative regulation of small GTPase mediated signal transduction; negative regulation of smooth muscle cell chemotaxis; negative regulation of vascular permeability; plasma membrane; positive regulation of apoptotic process; positive regulation of axonogenesis; protein homodimerization activity; response to cortisol stimulus; retinal ganglion cell axon guidance; ureteric bud development IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product] SLIT2 SLIL3 Homo sapiens (Human) TR39983_c1_g2_i3 O94813 SLIT2_HUMAN 2.00E-09 GO:0005095; GO:0035385; GO:0061364; GO:0048846; GO:0048754; GO:0005509; GO:0002042; GO:0009986; GO:0016337; GO:0071504; GO:0032870; GO:0045499; GO:0021836; GO:0021972; GO:0005737; GO:0033563; GO:0005615; GO:0008201; GO:0001701; GO:0050929; GO:0043237; GO:0060763; GO:0001656; GO:0008045; GO:0030837; GO:0030308; GO:0008285; GO:0090288; GO:0070100; GO:0010596; GO:0010629; GO:0010593; GO:0090027; GO:0071676; GO:0090024; GO:0001933; GO:0090260; GO:0051058; GO:0071672; GO:0043116; GO:0005886; GO:0043065; GO:0050772; GO:0042803; GO:0051414; GO:0031290; GO:0001657 Itself GTPase inhibitor activity; Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; branching morphogenesis of an epithelial tube; calcium ion binding; cell migration involved in sprouting angiogenesis; cell surface; cell-cell adhesion; cellular response to heparin; cellular response to hormone stimulus; chemorepellent activity; chemorepulsion involved in postnatal olfactory bulb interneuron migration; corticospinal neuron axon guidance through spinal cord; cytoplasm; dorsal/ventral axon guidance; extracellular space; heparin binding; in utero embryonic development; induction of negative chemotaxis; laminin-1 binding; mammary duct terminal end bud growth; metanephros development; motor neuron axon guidance; negative regulation of actin filament polymerization; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cellular response to growth factor stimulus; negative regulation of chemokine-mediated signaling pathway; negative regulation of endothelial cell migration; negative regulation of gene expression; negative regulation of lamellipodium assembly; negative regulation of monocyte chemotaxis; negative regulation of mononuclear cell migration; negative regulation of neutrophil chemotaxis; negative regulation of protein phosphorylation; negative regulation of retinal ganglion cell axon guidance; negative regulation of small GTPase mediated signal transduction; negative regulation of smooth muscle cell chemotaxis; negative regulation of vascular permeability; plasma membrane; positive regulation of apoptotic process; positive regulation of axonogenesis; protein homodimerization activity; response to cortisol stimulus; retinal ganglion cell axon guidance; ureteric bud development IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product] SLIT2 SLIL3 Homo sapiens (Human) TR39984_c2_g2_i1 Q9EQD2 NPFF2_RAT 3.00E-08 GO:0015629; GO:0016021; GO:0008188; GO:0007218; GO:0005886; GO:0043408; GO:0045761; GO:2000479 actin cytoskeleton; integral to membrane; neuropeptide receptor activity; neuropeptide signaling pathway; plasma membrane; regulation of MAPK cascade; regulation of adenylate cyclase activity; regulation of cAMP-dependent protein kinase activity IPR000276; IPR017452; IPR005395; IPR005397; Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide G-protein coupled receptor) Npffr2 Gpr74 Npff2 Npgpr Rattus norvegicus (Rat) TR39984_c2_g3_i5 Q18007 ACM1_CAEEL 7.00E-06 GO:0016907; GO:0005887; GO:0045211; GO:0007271 "G-protein coupled acetylcholine receptor activity; integral to plasma membrane; postsynaptic membrane; synaptic transmission, cholinergic" IPR000276; IPR017452; IPR000995; Probable muscarinic acetylcholine receptor gar-1 (G-protein-linked acetylcholine receptor 1) gar-1 C15B12.5 Caenorhabditis elegans TR39985_c2_g1_i2 A4IF97 ML12B_BOVIN 2.00E-68 GO:0030018; GO:0045177; GO:0005509; GO:0016460; GO:0008360; GO:0001725 Z disc; apical part of cell; calcium ion binding; myosin II complex; regulation of cell shape; stress fiber IPR011992; IPR018247; IPR002048; "Myosin regulatory light chain 12B (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2)" MYL12B MRLC2 MYLC2B Bos taurus (Bovine) TR39986_c0_g1_i2 Q01543 FLI1_HUMAN 3.00E-85 GO:0003677; GO:0000980; GO:0008015; GO:0003682; GO:0007599; GO:0035855; GO:0005634; GO:0009887; GO:0003700; GO:0006351 "DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding; blood circulation; chromatin binding; hemostasis; megakaryocyte development; nucleus; organ morphogenesis; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; Friend leukemia integration 1 transcription factor (Proto-oncogene Fli-1) (Transcription factor ERGB) FLI1 Homo sapiens (Human) TR39986_c0_g1_i4 Q04688 ELG_DROME 6.00E-36 GO:0005634; GO:0045451; GO:0010821; GO:0006355; GO:0043565; GO:0003700 "nucleus; pole plasm oskar mRNA localization; regulation of mitochondrion organization; regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity" IPR000418; IPR024668; IPR003118; IPR013761; IPR016312; IPR011991; DNA-binding protein Ets97D (D-elg) Ets97D elg CG6338 Drosophila melanogaster (Fruit fly) TR39987_c4_g1_i1 P22699 GUN6_DICDI 8.00E-49 GO:0008810; GO:0030245; GO:0030435 cellulase activity; cellulose catabolic process; sporulation resulting in formation of a cellular spore IPR008928; IPR012341; IPR001701; IPR018221; "Endoglucanase (EC 3.2.1.4) (Cellulase) (Endo-1,4-beta-glucanase) (Spore germination protein 270-6)" celA DDB_G0271134 Dictyostelium discoideum (Slime mold) TR39987_c4_g1_i5 O48766 GUN11_ARATH 1.00E-25 GO:0008810; GO:0030245; GO:0005576 cellulase activity; cellulose catabolic process; extracellular region IPR008928; IPR012341; IPR001701; IPR018221; "Endoglucanase 11 (EC 3.2.1.4) (Endo-1,4-beta glucanase 11)" At2g32990 T21L14.7 Arabidopsis thaliana (Mouse-ear cress) TR39987_c4_g1_i6 P22699 GUN6_DICDI 1.00E-25 GO:0008810; GO:0030245; GO:0030435 cellulase activity; cellulose catabolic process; sporulation resulting in formation of a cellular spore IPR008928; IPR012341; IPR001701; IPR018221; "Endoglucanase (EC 3.2.1.4) (Cellulase) (Endo-1,4-beta-glucanase) (Spore germination protein 270-6)" celA DDB_G0271134 Dictyostelium discoideum (Slime mold) TR39987_c5_g1_i2 Q8TBH0 ARRD2_HUMAN 2.00E-11 GO:0031410; GO:0005886; GO:0007165 cytoplasmic vesicle; plasma membrane; signal transduction IPR011021; IPR014752; IPR011022; IPR014756; Arrestin domain-containing protein 2 ARRDC2 PP2703 Homo sapiens (Human) TR39987_c7_g6_i1 A8AKR0 RNH_CITK8 6.00E-11 GO:0006401; GO:0005737; GO:0000287; GO:0003676; GO:0090305; GO:0004523 RNA catabolic process; cytoplasm; magnesium ion binding; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis; ribonuclease H activity IPR022892; IPR012337; IPR002156; Ribonuclease H (RNase H) (EC 3.1.26.4) rnhA CKO_02969 Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) TR39989_c3_g1_i1 Q10003 GPC1A_CAEEL 5.00E-80 GO:0006071; GO:0008889; GO:0006629; GO:2001070 glycerol metabolic process; glycerophosphodiester phosphodiesterase activity; lipid metabolic process; starch binding IPR013784; IPR002044; IPR004129; IPR013783; IPR017946; Putative glycerophosphocholine phosphodiesterase GPCPD1 homolog T05H10.7 (EC 3.1.-.-) T05H10.7 Caenorhabditis elegans TR39989_c3_g1_i3 Q9NPB8 GPCP1_HUMAN 4.00E-96 GO:0005829; GO:0006071; GO:0047389; GO:0008889; GO:0046474; GO:0044281; GO:2001070 cytosol; glycerol metabolic process; glycerophosphocholine phosphodiesterase activity; glycerophosphodiester phosphodiesterase activity; glycerophospholipid biosynthetic process; small molecule metabolic process; starch binding IPR013784; IPR002044; IPR004129; IPR013783; IPR017946; Glycerophosphocholine phosphodiesterase GPCPD1 (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 5) GPCPD1 GDE5 KIAA1434 Homo sapiens (Human) TR39989_c3_g1_i4 Q9NPB8 GPCP1_HUMAN 4.00E-94 GO:0005829; GO:0006071; GO:0047389; GO:0008889; GO:0046474; GO:0044281; GO:2001070 cytosol; glycerol metabolic process; glycerophosphocholine phosphodiesterase activity; glycerophosphodiester phosphodiesterase activity; glycerophospholipid biosynthetic process; small molecule metabolic process; starch binding IPR013784; IPR002044; IPR004129; IPR013783; IPR017946; Glycerophosphocholine phosphodiesterase GPCPD1 (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 5) GPCPD1 GDE5 KIAA1434 Homo sapiens (Human) TR39992_c0_g1_i1 P97576 GRPE1_RAT 6.00E-51 GO:0000774; GO:0005759; GO:0006457 adenyl-nucleotide exchange factor activity; mitochondrial matrix; protein folding IPR000740; IPR013805; IPR009012; "GrpE protein homolog 1, mitochondrial (Mt-GrpE#1)" Grpel1 Grepel1 Rattus norvegicus (Rat) TR39993_c1_g1_i1 Q02357 ANK1_MOUSE 1.00E-21 GO:0030863; GO:0048821; GO:0016020; GO:0015672; GO:0006779; GO:0016529; GO:0007165; GO:0014731 cortical cytoskeleton; erythrocyte development; membrane; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; sarcoplasmic reticulum; signal transduction; spectrin-associated cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) TR39993_c1_g1_i2 Q02357 ANK1_MOUSE 1.00E-21 GO:0030863; GO:0048821; GO:0016020; GO:0015672; GO:0006779; GO:0016529; GO:0007165; GO:0014731 cortical cytoskeleton; erythrocyte development; membrane; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; sarcoplasmic reticulum; signal transduction; spectrin-associated cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) TR39993_c1_g1_i5 Q2T9K6 FEM1C_XENLA 6.00E-14 GO:0005737; GO:0016567 cytoplasm; protein ubiquitination IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog C (FEM1c) (FEM1-gamma) fem1c Xenopus laevis (African clawed frog) TR39994_c3_g1_i1 Q38SD2 LRRK1_HUMAN 2.00E-61 GO:0005524; GO:0005525; GO:0046872; GO:0005739; GO:0004674; GO:0007264 Itself; P53355; Q5S007 ATP binding; GTP binding; metal ion binding; mitochondrion; protein serine/threonine kinase activity; small GTPase mediated signal transduction IPR002110; IPR020683; IPR011009; IPR001611; IPR025875; IPR003591; IPR013684; IPR027417; IPR000719; IPR020859; IPR017986; Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) LRRK1 KIAA1790 Homo sapiens (Human) TR39994_c3_g4_i1 Q3UHC2 LRRK1_MOUSE 5.00E-53 GO:0005524; GO:0005525; GO:0046872; GO:0005739; GO:0004674; GO:0007264 ATP binding; GTP binding; metal ion binding; mitochondrion; protein serine/threonine kinase activity; small GTPase mediated signal transduction IPR002110; IPR020683; IPR011009; IPR001611; IPR025875; IPR003591; IPR013684; IPR027417; IPR000719; IPR011044; IPR020859; Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) Lrrk1 Kiaa1790 Mus musculus (Mouse) TR39998_c1_g1_i6 A8C754 THADA_CHICK 7.00E-08 IPR011989; IPR016024; IPR019442; Thyroid adenoma-associated protein homolog THADA Gallus gallus (Chicken) TR39999_c1_g1_i1 Q68Y21 GRID2_DANRE 2.00E-11 GO:0030054; GO:0005234; GO:0016021; GO:0004970; GO:0035235; GO:0045211 cell junction; extracellular-glutamate-gated ion channel activity; integral to membrane; ionotropic glutamate receptor activity; ionotropic glutamate receptor signaling pathway; postsynaptic membrane IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; "Glutamate receptor ionotropic, delta-2 (GluD2) (GluR delta-2 subunit)" grid2 glurd2 Danio rerio (Zebrafish) (Brachydanio rerio) TR39999_c1_g2_i2 Q91756 GLRK_XENLA 2.00E-25 GO:0030054; GO:0005234; GO:0016021; GO:0004970; GO:0035235; GO:0045211 cell junction; extracellular-glutamate-gated ion channel activity; integral to membrane; ionotropic glutamate receptor activity; ionotropic glutamate receptor signaling pathway; postsynaptic membrane IPR019594; IPR001320; IPR001508; IPR001638; Glutamate receptor U1 (Kainate-binding protein) (Unitary non-NMDA glutamate receptor subunit 1) (XENU1) kbp Xenopus laevis (African clawed frog) TR39999_c1_g2_i3 Q91756 GLRK_XENLA 1.00E-25 GO:0030054; GO:0005234; GO:0016021; GO:0004970; GO:0035235; GO:0045211 cell junction; extracellular-glutamate-gated ion channel activity; integral to membrane; ionotropic glutamate receptor activity; ionotropic glutamate receptor signaling pathway; postsynaptic membrane IPR019594; IPR001320; IPR001508; IPR001638; Glutamate receptor U1 (Kainate-binding protein) (Unitary non-NMDA glutamate receptor subunit 1) (XENU1) kbp Xenopus laevis (African clawed frog) TR4_c0_g1_i1 Q8R151 ZNFX1_MOUSE 1.00E-16 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR40000_c0_g1_i2 Q02427 RBP1_DROME 2.00E-32 GO:0003729; GO:0045292; GO:0006376; GO:0000166; GO:0005634; GO:0035327 "mRNA binding; mRNA cis splicing, via spliceosome; mRNA splice site selection; nucleotide binding; nucleus; transcriptionally active chromatin" IPR012677; IPR000504; RNA-binding protein 1 Rbp1 Rbp11 CG17136 Drosophila melanogaster (Fruit fly) TR40000_c0_g1_i3 Q293V6 NCBP2_DROPS 4.00E-10 GO:0006370; GO:0000339; GO:0031047; GO:0045292; GO:0005846; GO:0000166; GO:0005634 "7-methylguanosine mRNA capping; RNA cap binding; gene silencing by RNA; mRNA cis splicing, via spliceosome; nuclear cap binding complex; nucleotide binding; nucleus" IPR027157; IPR012677; IPR000504; Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (NCBP 20 kDa subunit) (CBP20) Cbp20 GA11577 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR40001_c0_g3_i2 Q13263 TIF1B_HUMAN 1.00E-09 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR40004_c0_g1_i1 B3MF31 ANM7_DROAN 3.00E-16 GO:0005737; GO:0035243 cytoplasm; protein-arginine omega-N symmetric methyltransferase activity IPR025799; IPR014644; IPR010456; Protein arginine N-methyltransferase 7 (EC 2.1.1.-) Art7 GF11303 Drosophila ananassae (Fruit fly) TR40004_c0_g1_i2 Q6P2P2 ANM10_HUMAN 2.00E-96 GO:0005737; GO:0008276 cytoplasm; protein methyltransferase activity IPR025799; IPR010456; IPR013026; IPR011990; IPR013105; IPR019734; Putative protein arginine N-methyltransferase 10 (EC 2.1.1.-) PRMT10 Homo sapiens (Human) TR40004_c0_g1_i3 Q7QIL2 ANM7_ANOGA 1.00E-21 GO:0005737; GO:0035243 cytoplasm; protein-arginine omega-N symmetric methyltransferase activity IPR025799; IPR014644; IPR010456; Protein arginine N-methyltransferase 7 (EC 2.1.1.-) Art7 AGAP006938 Anopheles gambiae (African malaria mosquito) TR40004_c0_g1_i4 A0JMU5 ANM10_XENLA 5.00E-128 GO:0005737; GO:0008276 cytoplasm; protein methyltransferase activity IPR025799; IPR010456; IPR013026; IPR011990; IPR019734; Putative protein arginine N-methyltransferase 10 (EC 2.1.1.-) prmt10 Xenopus laevis (African clawed frog) TR40006_c1_g1_i1 Q92547 TOPB1_HUMAN 1.00E-54 GO:0003677; GO:0006281; GO:0016605; GO:0005694; GO:0000794; GO:0005737; GO:0001673; GO:0005815; GO:0008022; GO:0010212; GO:0000922 Itself; P31749; O75419; P03120; Q01094; Q13105 DNA binding; DNA repair; PML body; chromosome; condensed nuclear chromosome; cytoplasm; male germ cell nucleus; microtubule organizing center; protein C-terminus binding; response to ionizing radiation; spindle pole IPR001357; IPR016126; IPR026993; DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) TOPBP1 KIAA0259 Homo sapiens (Human) TR40006_c1_g1_i3 Q92547 TOPB1_HUMAN 8.00E-26 GO:0003677; GO:0006281; GO:0016605; GO:0005694; GO:0000794; GO:0005737; GO:0001673; GO:0005815; GO:0008022; GO:0010212; GO:0000922 Itself; P31749; O75419; P03120; Q01094; Q13105 DNA binding; DNA repair; PML body; chromosome; condensed nuclear chromosome; cytoplasm; male germ cell nucleus; microtubule organizing center; protein C-terminus binding; response to ionizing radiation; spindle pole IPR001357; IPR016126; IPR026993; DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) TOPBP1 KIAA0259 Homo sapiens (Human) TR40007_c0_g2_i1 Q5RCS8 VATD_PONAB 2.00E-109 GO:0042626; GO:0005813; GO:0005929; GO:0042384; GO:0061512; GO:0015992; GO:0016471 "ATPase activity, coupled to transmembrane movement of substances; centrosome; cilium; cilium assembly; protein localization to cilium; proton transport; vacuolar proton-transporting V-type ATPase complex" IPR002699; V-type proton ATPase subunit D (V-ATPase subunit D) (Vacuolar proton pump subunit D) ATP6V1D Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40007_c0_g2_i2 O59941 VATD_NEUCR 4.00E-67 GO:0046961; GO:0007035; GO:0016471 "proton-transporting ATPase activity, rotational mechanism; vacuolar acidification; vacuolar proton-transporting V-type ATPase complex" IPR002699; V-type proton ATPase subunit D (V-ATPase subunit D) (Vacuolar proton pump subunit D) vma-8 B2E7.040 NCU08035 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR40007_c0_g2_i3 Q9V7D2 VATD1_DROME 3.00E-104 GO:0015991; GO:0042626; GO:0033181; GO:0000221 "ATP hydrolysis coupled proton transport; ATPase activity, coupled to transmembrane movement of substances; plasma membrane proton-transporting V-type ATPase complex; vacuolar proton-transporting V-type ATPase, V1 domain" IPR002699; V-type proton ATPase subunit D 1 (V-ATPase subunit D 1) (Vacuolar H+ ATPase subunit 36-1) (Vacuolar proton pump subunit D 1) (dV-ATPase D) Vha36-1 Vha36 CG8186 Drosophila melanogaster (Fruit fly) TR40008_c2_g1_i1 P31429 DPEP1_RABIT 1.00E-126 GO:0034235; GO:0031225; GO:0016999; GO:0045177; GO:0016324; GO:0071277; GO:0035690; GO:0071732; GO:0043027; GO:0008239; GO:0005615; GO:0050667; GO:0070573; GO:0031528; GO:0072341; GO:0043066; GO:0030336; GO:0005886; GO:0006508; GO:0008270 GPI anchor binding; anchored to membrane; antibiotic metabolic process; apical part of cell; apical plasma membrane; cellular response to calcium ion; cellular response to drug; cellular response to nitric oxide; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; dipeptidyl-peptidase activity; extracellular space; homocysteine metabolic process; metallodipeptidase activity; microvillus membrane; modified amino acid binding; negative regulation of apoptotic process; negative regulation of cell migration; plasma membrane; proteolysis; zinc ion binding IPR000180; IPR008257; Dipeptidase 1 (EC 3.4.13.19) (43 kDa renal band 3-related protein) (Microsomal dipeptidase) DPEP1 Oryctolagus cuniculus (Rabbit) TR40009_c0_g6_i2 P78333 GPC5_HUMAN 1.00E-29 GO:0005796; GO:0031225; GO:0005975; GO:0030204; GO:0005615; GO:0006024; GO:0006027; GO:0005887; GO:0043202; GO:0007603; GO:0005578; GO:0001523 "Golgi lumen; anchored to membrane; carbohydrate metabolic process; chondroitin sulfate metabolic process; extracellular space; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; integral to plasma membrane; lysosomal lumen; phototransduction, visible light; proteinaceous extracellular matrix; retinoid metabolic process" IPR001863; IPR019803; Glypican-5 [Cleaved into: Secreted glypican-5] GPC5 Homo sapiens (Human) TR40009_c0_g6_i3 Q8CAL5 GPC5_MOUSE 2.00E-32 GO:0005796; GO:0031225; GO:0005615; GO:0005887; GO:0005578 Golgi lumen; anchored to membrane; extracellular space; integral to plasma membrane; proteinaceous extracellular matrix IPR001863; IPR019803; Glypican-5 [Cleaved into: Secreted glypican-5] Gpc5 Mus musculus (Mouse) TR40010_c0_g1_i2 Q5IGR7 EXT1B_DANRE 0 GO:0050509; GO:0050508; GO:0015012; GO:0030176; GO:0006486 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; heparan sulfate proteoglycan biosynthetic process; integral to endoplasmic reticulum membrane; protein glycosylation IPR004263; IPR027670; IPR015338; Protein modification; protein glycosylation. Exostosin-1b (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase 1b) (Multiple exostoses protein 1 homolog b) ext1b Danio rerio (Zebrafish) (Brachydanio rerio) TR40011_c2_g2_i3 P49758 RGS6_HUMAN 1.00E-81 GO:0007186; GO:0005096; GO:0005737; GO:0005834; GO:0035556; GO:0005886; GO:0045666; GO:0008277; GO:0004871; GO:0038032 P08238 G-protein coupled receptor signaling pathway; GTPase activator activity; cytoplasm; heterotrimeric G-protein complex; intracellular signal transduction; plasma membrane; positive regulation of neuron differentiation; regulation of G-protein coupled receptor protein signaling pathway; signal transducer activity; termination of G-protein coupled receptor signaling pathway IPR000591; IPR015898; IPR024066; IPR016137; IPR000342; IPR011991; Regulator of G-protein signaling 6 (RGS6) (S914) RGS6 Homo sapiens (Human) TR40011_c2_g2_i4 P49809 EGL10_CAEEL 1.00E-34 GO:0005096; GO:0005737; GO:0007212; GO:0007631; GO:0005834; GO:0035556; GO:0043005; GO:0005886; GO:0040017; GO:0008277; GO:0046662; GO:0007622; GO:0004871; GO:0038032 GTPase activator activity; cytoplasm; dopamine receptor signaling pathway; feeding behavior; heterotrimeric G-protein complex; intracellular signal transduction; neuron projection; plasma membrane; positive regulation of locomotion; regulation of G-protein coupled receptor protein signaling pathway; regulation of oviposition; rhythmic behavior; signal transducer activity; termination of G-protein coupled receptor signaling pathway IPR000591; IPR015898; IPR024066; IPR016137; IPR000342; IPR011991; Regulator of G-protein signaling egl-10 (Egg-laying defective protein 10) egl-10 F28C1.2 Caenorhabditis elegans TR40012_c0_g1_i10 Q969V5 MUL1_HUMAN 8.00E-47 GO:0019789; GO:0007257; GO:0006919; GO:0031307; GO:0000266; GO:0051646; GO:0030308; GO:0010637; GO:0005634; GO:0005777; GO:0043123; GO:0090141; GO:0033235; GO:0050821; GO:0016925; GO:1901028; GO:0004871; GO:0004842; GO:0008270 Q92624 SUMO ligase activity; activation of JUN kinase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; integral to mitochondrial outer membrane; mitochondrial fission; mitochondrion localization; negative regulation of cell growth; negative regulation of mitochondrial fusion; nucleus; peroxisome; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of mitochondrial fission; positive regulation of protein sumoylation; protein stabilization; protein sumoylation; regulation of mitochondrial outer membrane permeabilization; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR022170; IPR001841; IPR013083; Protein modification; protein ubiquitination. Protein modification; protein sumoylation. Mitochondrial ubiquitin ligase activator of NFKB 1 (EC 6.3.2.-) (E3 SUMO-protein ligase MUL1) (E3 ubiquitin-protein ligase MUL1) (Growth inhibition and death E3 ligase) (Mitochondrial-anchored protein ligase) (MAPL) (Putative NF-kappa-B-activating protein 266) (RING finger protein 218) MUL1 C1orf166 GIDE MAPL MULAN RNF218 Homo sapiens (Human) TR40012_c0_g1_i3 Q7M3S9 RNGB_DICDI 4.00E-08 GO:0005737; GO:0008270 cytoplasm; zinc ion binding IPR015915; IPR006652; IPR001841; IPR013083; RING finger protein B (Protein rngB) rngB DDB_G0268860 Dictyostelium discoideum (Slime mold) TR40012_c0_g1_i4 Q969V5 MUL1_HUMAN 1.00E-46 GO:0019789; GO:0007257; GO:0006919; GO:0031307; GO:0000266; GO:0051646; GO:0030308; GO:0010637; GO:0005634; GO:0005777; GO:0043123; GO:0090141; GO:0033235; GO:0050821; GO:0016925; GO:1901028; GO:0004871; GO:0004842; GO:0008270 Q92624 SUMO ligase activity; activation of JUN kinase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; integral to mitochondrial outer membrane; mitochondrial fission; mitochondrion localization; negative regulation of cell growth; negative regulation of mitochondrial fusion; nucleus; peroxisome; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of mitochondrial fission; positive regulation of protein sumoylation; protein stabilization; protein sumoylation; regulation of mitochondrial outer membrane permeabilization; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR022170; IPR001841; IPR013083; Protein modification; protein ubiquitination. Protein modification; protein sumoylation. Mitochondrial ubiquitin ligase activator of NFKB 1 (EC 6.3.2.-) (E3 SUMO-protein ligase MUL1) (E3 ubiquitin-protein ligase MUL1) (Growth inhibition and death E3 ligase) (Mitochondrial-anchored protein ligase) (MAPL) (Putative NF-kappa-B-activating protein 266) (RING finger protein 218) MUL1 C1orf166 GIDE MAPL MULAN RNF218 Homo sapiens (Human) TR40012_c0_g1_i6 Q84ME1 LUL3_ARATH 4.00E-07 GO:0004842; GO:0008270 ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase LUL3 (EC 6.3.2.-) (Protein LOG2-LIKE UBIQUITIN LIGASE 3) (RING finger protein 398) LUL3 RF398 At5g19080 T16G12.120 Arabidopsis thaliana (Mouse-ear cress) TR40012_c0_g1_i8 Q6NTT6 MUL1_XENLA 1.00E-45 GO:0006919; GO:0042802; GO:0031307; GO:0000266; GO:0051646; GO:0030308; GO:0005777; GO:0043123; GO:0004871; GO:0004842; GO:0008270 activation of cysteine-type endopeptidase activity involved in apoptotic process; identical protein binding; integral to mitochondrial outer membrane; mitochondrial fission; mitochondrion localization; negative regulation of cell growth; peroxisome; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR022170; IPR001841; IPR013083; Protein modification; protein ubiquitination. Mitochondrial ubiquitin ligase activator of nfkb 1 (EC 6.3.2.-) (E3 ubiquitin-protein ligase mul1) mul1 Xenopus laevis (African clawed frog) TR40012_c0_g1_i9 Q7M3S9 RNGB_DICDI 4.00E-08 GO:0005737; GO:0008270 cytoplasm; zinc ion binding IPR015915; IPR006652; IPR001841; IPR013083; RING finger protein B (Protein rngB) rngB DDB_G0268860 Dictyostelium discoideum (Slime mold) TR40013_c0_g1_i2 Q9D361 SNR48_MOUSE 3.00E-35 GO:0008380; GO:0005689; GO:0005737; GO:0006397; GO:0046872 RNA splicing; U12-type spliceosomal complex; cytoplasm; mRNA processing; metal ion binding IPR022776; IPR007917; U11/U12 small nuclear ribonucleoprotein 48 kDa protein (U11/U12 snRNP 48 kDa protein) Snrnp48 Mus musculus (Mouse) TR40014_c1_g1_i1 Q9VU68 WDR1_DROME 0 GO:0003779; GO:0030042; GO:0005737; GO:0005856; GO:0001736; GO:0035317; GO:0006909; GO:0030834; GO:0045214 actin binding; actin filament depolymerization; cytoplasm; cytoskeleton; establishment of planar polarity; imaginal disc-derived wing hair organization; phagocytosis; regulation of actin filament depolymerization; sarcomere organization IPR015943; IPR001680; IPR017986; Actin-interacting protein 1 (AIP1) (Protein flare) flr CG10724 Drosophila melanogaster (Fruit fly) TR40014_c1_g1_i2 Q9VU68 WDR1_DROME 0 GO:0003779; GO:0030042; GO:0005737; GO:0005856; GO:0001736; GO:0035317; GO:0006909; GO:0030834; GO:0045214 actin binding; actin filament depolymerization; cytoplasm; cytoskeleton; establishment of planar polarity; imaginal disc-derived wing hair organization; phagocytosis; regulation of actin filament depolymerization; sarcomere organization IPR015943; IPR001680; IPR017986; Actin-interacting protein 1 (AIP1) (Protein flare) flr CG10724 Drosophila melanogaster (Fruit fly) TR40014_c1_g1_i3 O18640 GBLP_DROME 3.00E-10 GO:0005776; GO:0071013; GO:0042335; GO:0007626; GO:0000398; GO:0005875; GO:0046716; GO:0048477; GO:0018991; GO:0045725; GO:0071011; GO:0016243; GO:0035220 "autophagic vacuole; catalytic step 2 spliceosome; cuticle development; locomotory behavior; mRNA splicing, via spliceosome; microtubule associated complex; muscle cell cellular homeostasis; oogenesis; oviposition; positive regulation of glycogen biosynthetic process; precatalytic spliceosome; regulation of autophagic vacuole size; wing disc development" IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Guanine nucleotide-binding protein subunit beta-like protein (Receptor of activated protein kinase C homolog) Rack1 CG7111 Drosophila melanogaster (Fruit fly) TR40015_c0_g1_i1 Q9GZQ8 MLP3B_HUMAN 4.00E-54 GO:0005776; GO:0000421; GO:0006914; GO:0031410; GO:0012505; GO:0005874; GO:0031090 O75143; Q676U5; Q2TAZ0; Q9NT62; Q9Y4P1; Q9H1Y0; O95352; Q9Z2F7; Q14677; Q9BQS8; O75323; P40939; O00410; Q86V97; Q8WVZ9; Q9Y383; Q14596; P97432; Q8TD19; Q9BXM7; Q9NS23; Q8WWW0; Q15424; Q14151; Q13501; Q64337; O95210; Q13188; Q13043; Q8TC07; Q9UPU7; Q9GZZ9; O75385 autophagic vacuole; autophagic vacuole membrane; autophagy; cytoplasmic vesicle; endomembrane system; microtubule; organelle membrane IPR004241; Microtubule-associated proteins 1A/1B light chain 3B (Autophagy-related protein LC3 B) (Autophagy-related ubiquitin-like modifier LC3 B) (MAP1 light chain 3-like protein 2) (MAP1A/MAP1B light chain 3 B) (MAP1A/MAP1B LC3 B) (Microtubule-associated protein 1 light chain 3 beta) MAP1LC3B MAP1ALC3 Homo sapiens (Human) TR40015_c0_g1_i3 P0CO54 ATG8_CRYNJ 4.00E-23 GO:0033110; GO:0000421; GO:0006914; GO:0015031 Cvt vesicle membrane; autophagic vacuole membrane; autophagy; protein transport IPR004241; Autophagy-related protein 8 (Autophagy-related ubiquitin-like modifier ATG8) ATG8 CNA07930 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR40016_c4_g2_i1 Q53GL7 PAR10_HUMAN 2.00E-36 GO:0005794; GO:0003950; GO:0048147; GO:0005634; GO:0070212; GO:0010847 Q9Y530 Golgi apparatus; NAD+ ADP-ribosyltransferase activity; negative regulation of fibroblast proliferation; nucleus; protein poly-ADP-ribosylation; regulation of chromatin assembly IPR012317; IPR003903; Poly [ADP-ribose] polymerase 10 (PARP-10) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) PARP10 Homo sapiens (Human) TR40016_c4_g2_i2 Q460N5 PAR14_HUMAN 4.00E-82 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR40016_c4_g2_i3 Q96XY5 Y2383_SULTO 9.00E-12 IPR002589; Uncharacterized protein STK_23830 STK_23830 Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) TR40017_c1_g1_i2 A4IFA6 ISLR_BOVIN 5.00E-08 GO:0005576 extracellular region IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Immunoglobulin superfamily containing leucine-rich repeat protein ISLR Bos taurus (Bovine) TR40019_c1_g2_i13 Q6AZB8 HARB1_DANRE 1.00E-05 GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) TR40020_c0_g1_i1 Q5M8V6 GTPBA_XENTR 4.00E-87 GO:0005525; GO:0006184; GO:0003924; GO:0000287; GO:0005730; GO:0042254 GTP binding; GTP catabolic process; GTPase activity; magnesium ion binding; nucleolus; ribosome biogenesis IPR014100; IPR006169; IPR006073; IPR027417; GTP-binding protein 10 gtpbp10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40020_c0_g1_i2 O67849 OBG_AQUAE 1.00E-52 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0000287 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; magnesium ion binding IPR014100; IPR006169; IPR006073; IPR027417; IPR005225; GTPase obg (GTP-binding protein obg) obg aq_2069 Aquifex aeolicus (strain VF5) TR40020_c1_g3_i1 Q4V838 LTV1_XENLA 5.00E-07 IPR007307; Protein LTV1 homolog ltv1 Xenopus laevis (African clawed frog) TR40020_c1_g4_i1 Q6NSQ7 LTV1_MOUSE 4.00E-85 GO:0005737; GO:0005634 cytoplasm; nucleus IPR007307; Protein LTV1 homolog Ltv1 Mus musculus (Mouse) TR40023_c3_g1_i1 Q03FR6 DNAJ_PEDPA 2.00E-14 GO:0005524; GO:0006260; GO:0005737; GO:0006457; GO:0009408; GO:0008270 ATP binding; DNA replication; cytoplasm; protein folding; response to heat; zinc ion binding IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; Chaperone protein DnaJ dnaJ PEPE_0897 Pediococcus pentosaceus (strain ATCC 25745 / 183-1w) TR40023_c3_g1_i2 Q03FR6 DNAJ_PEDPA 3.00E-14 GO:0005524; GO:0006260; GO:0005737; GO:0006457; GO:0009408; GO:0008270 ATP binding; DNA replication; cytoplasm; protein folding; response to heat; zinc ion binding IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; Chaperone protein DnaJ dnaJ PEPE_0897 Pediococcus pentosaceus (strain ATCC 25745 / 183-1w) TR40023_c4_g2_i2 A5D8Q0 XIAP_XENLA 4.00E-11 GO:0016055; GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0045861; GO:0090263; GO:0008270 Wnt receptor signaling pathway; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; negative regulation of proteolysis; positive regulation of canonical Wnt receptor signaling pathway; zinc ion binding IPR001370; IPR001841; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (xXIAP) xiap birc4 Xenopus laevis (African clawed frog) TR40023_c4_g2_i3 A9JTP3 BIRC7_XENTR 3.00E-36 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP) (Embryonic/Egg IAP) (EIAP/XLX) birc7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40023_c4_g2_i4 Q13490 BIRC2_HUMAN 8.00E-22 GO:0035631; GO:0038061; GO:0035666; GO:0007166; GO:0006921; GO:0005829; GO:0045087; GO:0009898; GO:0070266; GO:0043066; GO:0005634; GO:0001890; GO:0043123; GO:0043161; GO:0000209; GO:0039535; GO:0051726; GO:0045595; GO:0042127; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0006355; GO:0034138; GO:0034142; GO:0003713; GO:0006351; GO:0004842; GO:0008270 P55210; Q9NR28; P63000; Q13546; O43353; Q9Y572; P57078; Q9NP84; Q12933 "CD40 receptor complex; NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; cell surface receptor signaling pathway; cellular component disassembly involved in execution phase of apoptosis; cytosol; innate immune response; internal side of plasma membrane; necroptosis; negative regulation of apoptotic process; nucleus; placenta development; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of RIG-I signaling pathway; regulation of cell cycle; regulation of cell differentiation; regulation of cell proliferation; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; regulation of transcription, DNA-dependent; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (IAP-2) (hIAP-2) (hIAP2) (RING finger protein 48) (TNFR2-TRAF-signaling complex protein 2) BIRC2 API1 IAP2 MIHB RNF48 Homo sapiens (Human) TR40023_c4_g2_i5 Q13489 BIRC3_HUMAN 3.00E-19 GO:0038061; GO:0035666; GO:0006915; GO:0007166; GO:0005829; GO:0045087; GO:0070266; GO:0043066; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0043123; GO:0039535; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0034138; GO:0034142; GO:0004842; GO:0008270 Q13546; O43353; Q9Y572; P57078; Q12933 NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; apoptotic process; cell surface receptor signaling pathway; cytosol; innate immune response; necroptosis; negative regulation of apoptotic process; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of RIG-I signaling pathway; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Apoptosis inhibitor 2) (API2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (IAP-1) (hIAP-1) (hIAP1) (RING finger protein 49) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 IAP1 MIHC RNF49 Homo sapiens (Human) TR40023_c4_g2_i6 Q9QUK4 BIR1B_MOUSE 5.00E-11 GO:0005524; GO:0072557; GO:0006915; GO:0071391; GO:0042742; GO:0016045; GO:0006954; GO:0045087; GO:0046872; GO:0070269 ATP binding; IPAF inflammasome complex; apoptotic process; cellular response to estrogen stimulus; defense response to bacterium; detection of bacterium; inflammatory response; innate immune response; metal ion binding; pyroptosis IPR001370; IPR007111; IPR027417; Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2) Naip2 Birc1b Naip-rs6 Mus musculus (Mouse) TR40023_c4_g2_i7 Q8JHV9 BIR7A_XENLA 8.00E-42 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR40023_c4_g2_i8 Q8JHV9 BIR7A_XENLA 6.00E-40 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR40024_c0_g1_i1 Q9V730 EXT1_DROME 1.00E-126 GO:0005794; GO:0000139; GO:0006044; GO:0050509; GO:0016055; GO:0007411; GO:0008101; GO:0005783; GO:0008354; GO:0050508; GO:0015014; GO:0030210; GO:0016021; GO:0048312; GO:0031227; GO:0006486; GO:0008589; GO:0007224; GO:0050808; GO:0048488 Q9Y169 "Golgi apparatus; Golgi membrane; N-acetylglucosamine metabolic process; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity; Wnt receptor signaling pathway; axon guidance; decapentaplegic signaling pathway; endoplasmic reticulum; germ cell migration; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; heparin biosynthetic process; integral to membrane; intracellular distribution of mitochondria; intrinsic to endoplasmic reticulum membrane; protein glycosylation; regulation of smoothened signaling pathway; smoothened signaling pathway; synapse organization; synaptic vesicle endocytosis" IPR004263; IPR027670; IPR015338; Protein modification; protein glycosylation. Glycan metabolism; heparan sulfate biosynthesis. Glycan metabolism; heparin biosynthesis. Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225) (Protein tout-velu) ttv DEXT1 CG10117 Drosophila melanogaster (Fruit fly) TR40024_c0_g1_i2 O77783 EXT2_BOVIN 0 GO:0000139; GO:0006044; GO:0050509; GO:0005615; GO:0050508; GO:0006024; GO:0015012; GO:0016021; GO:0031227; GO:0006486 Golgi membrane; N-acetylglucosamine metabolic process; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity; extracellular space; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process; integral to membrane; intrinsic to endoplasmic reticulum membrane; protein glycosylation IPR004263; IPR027673; IPR015338; Protein modification; protein glycosylation. Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (HS-polymerase) (HS-POL) (Multiple exostoses protein 2 homolog) EXT2 Bos taurus (Bovine) TR40024_c0_g1_i3 Q9WVL6 EXTL3_MOUSE 6.00E-74 GO:0001888; GO:0015012; GO:0016021; GO:0031227; GO:0046872 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; heparan sulfate proteoglycan biosynthetic process; integral to membrane; intrinsic to endoplasmic reticulum membrane; metal ion binding IPR027674; IPR004263; IPR015338; Glycan metabolism; heparan sulfate biosynthesis. Exostosin-like 3 (EC 2.4.1.223) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostosis-like protein 3) Extl3 Mus musculus (Mouse) TR40027_c0_g1_i1 Q96EY1 DNJA3_HUMAN 7.00E-14 GO:0005524; GO:0033077; GO:0006919; GO:0006924; GO:0007569; GO:0030054; GO:0005829; GO:0009790; GO:0019897; GO:0005133; GO:0046872; GO:0006264; GO:0005759; GO:0042645; GO:0043124; GO:0032088; GO:0043066; GO:0008285; GO:0043154; GO:0060336; GO:0006469; GO:0000122; GO:0031594; GO:0007528; GO:0005634; GO:0042102; GO:0043065; GO:0031398; GO:0045211; GO:0006457; GO:0050821; GO:0009408; GO:0034341; GO:0071340; GO:0007264; GO:0005083 Q86X55; O60341; P08581; Q96LA8; P51692; P42232 ATP binding; T cell differentiation in thymus; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation-induced cell death of T cells; cell aging; cell junction; cytosol; embryo development; extrinsic to plasma membrane; interferon-gamma receptor binding; metal ion binding; mitochondrial DNA replication; mitochondrial matrix; mitochondrial nucleoid; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of apoptotic process; negative regulation of cell proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of interferon-gamma-mediated signaling pathway; negative regulation of protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; neuromuscular junction; neuromuscular junction development; nucleus; positive regulation of T cell proliferation; positive regulation of apoptotic process; positive regulation of protein ubiquitination; postsynaptic membrane; protein folding; protein stabilization; response to heat; response to interferon-gamma; skeletal muscle acetylcholine-gated channel clustering; small GTPase mediated signal transduction; small GTPase regulator activity IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; "DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)" DNAJA3 HCA57 TID1 Homo sapiens (Human) TR40027_c0_g1_i2 Q96EY1 DNJA3_HUMAN 2.00E-14 GO:0005524; GO:0033077; GO:0006919; GO:0006924; GO:0007569; GO:0030054; GO:0005829; GO:0009790; GO:0019897; GO:0005133; GO:0046872; GO:0006264; GO:0005759; GO:0042645; GO:0043124; GO:0032088; GO:0043066; GO:0008285; GO:0043154; GO:0060336; GO:0006469; GO:0000122; GO:0031594; GO:0007528; GO:0005634; GO:0042102; GO:0043065; GO:0031398; GO:0045211; GO:0006457; GO:0050821; GO:0009408; GO:0034341; GO:0071340; GO:0007264; GO:0005083 Q86X55; O60341; P08581; Q96LA8; P51692; P42232 ATP binding; T cell differentiation in thymus; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation-induced cell death of T cells; cell aging; cell junction; cytosol; embryo development; extrinsic to plasma membrane; interferon-gamma receptor binding; metal ion binding; mitochondrial DNA replication; mitochondrial matrix; mitochondrial nucleoid; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of apoptotic process; negative regulation of cell proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of interferon-gamma-mediated signaling pathway; negative regulation of protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; neuromuscular junction; neuromuscular junction development; nucleus; positive regulation of T cell proliferation; positive regulation of apoptotic process; positive regulation of protein ubiquitination; postsynaptic membrane; protein folding; protein stabilization; response to heat; response to interferon-gamma; skeletal muscle acetylcholine-gated channel clustering; small GTPase mediated signal transduction; small GTPase regulator activity IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; "DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)" DNAJA3 HCA57 TID1 Homo sapiens (Human) TR40027_c0_g1_i4 Q6L0S6 DNAJ_PICTO 3.00E-14 GO:0005524; GO:0006260; GO:0005737; GO:0006457; GO:0009408; GO:0008270 ATP binding; DNA replication; cytoplasm; protein folding; response to heat; zinc ion binding IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; Chaperone protein DnaJ dnaJ PTO0841 Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) TR40027_c0_g1_i7 B2J3J3 DNAJ_NOSP7 6.00E-12 GO:0005524; GO:0006260; GO:0005737; GO:0006457; GO:0009408; GO:0008270 ATP binding; DNA replication; cytoplasm; protein folding; response to heat; zinc ion binding IPR012724; IPR002939; IPR001623; IPR008971; IPR001305; Chaperone protein DnaJ dnaJ Npun_F0123 Nostoc punctiforme (strain ATCC 29133 / PCC 73102) TR40027_c0_g2_i1 Q93S23 DNAJ_RHITR 6.00E-07 GO:0005524; GO:0006260; GO:0005737; GO:0046872; GO:0006457; GO:0009408 ATP binding; DNA replication; cytoplasm; metal ion binding; protein folding; response to heat IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; Chaperone protein DnaJ (Fragment) dnaJ Rhizobium tropici TR40028_c0_g4_i1 Q95YI3 OPSCE_BOMMO 4.00E-07 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR001391; IPR027430; Ceropsin (Cerebral opsin) (Boceropsin) Bcop Bombyx mori (Silk moth) TR40029_c0_g1_i1 Q8C165 P20D1_MOUSE 2.00E-06 GO:0005576; GO:0046872; GO:0008233; GO:0006508 extracellular region; metal ion binding; peptidase activity; proteolysis IPR002933; IPR011650; Probable carboxypeptidase PM20D1 (EC 3.4.17.-) (Peptidase M20 domain-containing protein 1) Pm20d1 Mus musculus (Mouse) TR40029_c0_g1_i4 Q3ZC84 CNDP2_BOVIN 0 GO:0004180; GO:0005737; GO:0016805; GO:0046872; GO:0008237; GO:0006508; GO:0034701 carboxypeptidase activity; cytoplasm; dipeptidase activity; metal ion binding; metallopeptidase activity; proteolysis; tripeptidase activity IPR001261; IPR017153; IPR002933; IPR011650; Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) CNDP2 Bos taurus (Bovine) TR40029_c0_g1_i5 Q08BB2 P2012_DANRE 5.00E-09 GO:0005576; GO:0046872; GO:0008233; GO:0006508 extracellular region; metal ion binding; peptidase activity; proteolysis IPR002933; IPR011650; Probable carboxypeptidase PM20D1.2 (EC 3.4.17.-) (Peptidase M20 domain-containing protein 1.2) pm20d1.2 zgc:154035 Danio rerio (Zebrafish) (Brachydanio rerio) TR40029_c0_g1_i6 Q9D1A2 CNDP2_MOUSE 7.00E-164 GO:0004180; GO:0005829; GO:0016805; GO:0046872; GO:0008237; GO:0006508; GO:0034701 carboxypeptidase activity; cytosol; dipeptidase activity; metal ion binding; metallopeptidase activity; proteolysis; tripeptidase activity IPR001261; IPR017153; IPR002933; IPR011650; Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Glutamate carboxypeptidase-like protein 1) Cndp2 Cn2 Mus musculus (Mouse) TR40032_c1_g5_i1 P39953 YEA6_YEAST 4.00E-27 GO:0035352; GO:0051724; GO:0016021; GO:0005743 NAD transmembrane transport; NAD transporter activity; integral to membrane; mitochondrial inner membrane IPR002067; IPR018108; IPR023395; Mitochondrial nicotinamide adenine dinucleotide transporter 2 (Mitochondrial NAD(+) transporter 2) YEA6 NDT2 YEL006W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40032_c1_g5_i2 O43808 PM34_HUMAN 7.00E-103 GO:0015217; GO:0080122; GO:0005347; GO:0015230; GO:0044610; GO:0051724; GO:0015228; GO:0001561; GO:0006635; GO:0015908; GO:0005779; GO:0005739 P40855 ADP transmembrane transporter activity; AMP transmembrane transporter activity; ATP transmembrane transporter activity; FAD transmembrane transporter activity; FMN transmembrane transporter activity; NAD transporter activity; coenzyme A transmembrane transporter activity; fatty acid alpha-oxidation; fatty acid beta-oxidation; fatty acid transport; integral to peroxisomal membrane; mitochondrion IPR002067; IPR018108; IPR023395; Peroxisomal membrane protein PMP34 (34 kDa peroxisomal membrane protein) (Solute carrier family 25 member 17) SLC25A17 PMP34 Homo sapiens (Human) TR40033_c0_g1_i3 Q6NVC5 MIRO1_DANRE 5.00E-07 GO:0005525; GO:0006184; GO:0003924; GO:0005509; GO:0019725; GO:0031307; GO:0097345; GO:0047497; GO:0007264 GTP binding; GTP catabolic process; GTPase activity; calcium ion binding; cellular homeostasis; integral to mitochondrial outer membrane; mitochondrial outer membrane permeabilization; mitochondrion transport along microtubule; small GTPase mediated signal transduction IPR011992; IPR018247; IPR013566; IPR013567; IPR002048; IPR020860; IPR013684; IPR027417; IPR021181; IPR005225; IPR001806; Mitochondrial Rho GTPase 1-A (MIRO-1-A) (EC 3.6.5.-) (Ras homolog gene family member T1-A) rhot1a zgc:55581 Danio rerio (Zebrafish) (Brachydanio rerio) TR40033_c0_g1_i4 Q8CFN2 CDC42_RAT 2.00E-44 GO:0005525; GO:0003924; GO:0000139; GO:0007030; GO:0090135; GO:0051017; GO:0034332; GO:0045177; GO:0060070; GO:0003161; GO:0034613; GO:0005829; GO:0090136; GO:0060684; GO:0051683; GO:0030010; GO:0035088; GO:0030175; GO:0046847; GO:0031069; GO:0060789; GO:0060047; GO:0031424; GO:0003334; GO:0005815; GO:0030496; GO:0072686; GO:0035264; GO:0010629; GO:0031333; GO:0048664; GO:0043005; GO:0043025; GO:0007097; GO:0072384; GO:0005886; GO:0045740; GO:0046330; GO:0032467; GO:0010628; GO:0071338; GO:0090316; GO:0048554; GO:0043525; GO:0033138; GO:0043552; GO:0031274; GO:1900026; GO:0051835; GO:0051988; GO:0017157; GO:0051489; GO:0007088; GO:0042176; GO:0043497; GO:0045859; GO:0031647; GO:0009749; GO:0030141; GO:0007264; GO:0051233; GO:0002040; GO:0060661 Q9UQB8 GTP binding; GTPase activity; Golgi membrane; Golgi organization; actin filament branching; actin filament bundle assembly; adherens junction organization; apical part of cell; canonical Wnt receptor signaling pathway; cardiac conduction system development; cellular protein localization; cytosol; epithelial cell-cell adhesion; epithelial-mesenchymal cell signaling; establishment of Golgi localization; establishment of cell polarity; establishment or maintenance of apical/basal cell polarity; filopodium; filopodium assembly; hair follicle morphogenesis; hair follicle placode formation; heart contraction; keratinization; keratinocyte development; microtubule organizing center; midbody; mitotic spindle; multicellular organism growth; negative regulation of gene expression; negative regulation of protein complex assembly; neuron fate determination; neuron projection; neuronal cell body; nuclear migration; organelle transport along microtubule; plasma membrane; positive regulation of DNA replication; positive regulation of JNK cascade; positive regulation of cytokinesis; positive regulation of gene expression; positive regulation of hair follicle cell proliferation; positive regulation of intracellular protein transport; positive regulation of metalloenzyme activity; positive regulation of neuron apoptotic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of pseudopodium assembly; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of synapse structural plasticity; regulation of attachment of spindle microtubules to kinetochore; regulation of exocytosis; regulation of filopodium assembly; regulation of mitosis; regulation of protein catabolic process; regulation of protein heterodimerization activity; regulation of protein kinase activity; regulation of protein stability; response to glucose stimulus; secretory granule; small GTPase mediated signal transduction; spindle midzone; sprouting angiogenesis; submandibular salivary gland formation IPR027417; IPR005225; IPR001806; IPR003578; Cell division control protein 42 homolog Cdc42 Rattus norvegicus (Rat) TR40033_c0_g1_i6 P84096 RHOG_MOUSE 3.00E-40 GO:0005525; GO:0003924; GO:0016601; GO:0007266; GO:0030036; GO:0032863; GO:0060326; GO:0005622; GO:0005886; GO:0090004; GO:0045893 "GTP binding; GTPase activity; Rac protein signal transduction; Rho protein signal transduction; actin cytoskeleton organization; activation of Rac GTPase activity; cell chemotaxis; intracellular; plasma membrane; positive regulation of establishment of protein localization to plasma membrane; positive regulation of transcription, DNA-dependent" IPR027417; IPR005225; IPR001806; IPR003578; Rho-related GTP-binding protein RhoG (Sid 10750) Rhog Arhg Sid10750 Mus musculus (Mouse) TR40033_c0_g1_i7 Q9EQT3 RHOU_MOUSE 3.00E-40 GO:0000082; GO:0005525; GO:0003924; GO:0000139; GO:0016601; GO:0030036; GO:0042995; GO:0005925; GO:0046872; GO:0005886; GO:0002102; GO:0008360 G1/S transition of mitotic cell cycle; GTP binding; GTPase activity; Golgi membrane; Rac protein signal transduction; actin cytoskeleton organization; cell projection; focal adhesion; metal ion binding; plasma membrane; podosome; regulation of cell shape IPR027417; IPR005225; IPR001806; IPR003578; Rho-related GTP-binding protein RhoU (Rho GTPase-like protein ARHU) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1) Rhou Arhu G28k Wrch1 Mus musculus (Mouse) TR40033_c0_g1_i8 Q8CFN2 CDC42_RAT 6.00E-45 GO:0005525; GO:0003924; GO:0000139; GO:0007030; GO:0090135; GO:0051017; GO:0034332; GO:0045177; GO:0060070; GO:0003161; GO:0034613; GO:0005829; GO:0090136; GO:0060684; GO:0051683; GO:0030010; GO:0035088; GO:0030175; GO:0046847; GO:0031069; GO:0060789; GO:0060047; GO:0031424; GO:0003334; GO:0005815; GO:0030496; GO:0072686; GO:0035264; GO:0010629; GO:0031333; GO:0048664; GO:0043005; GO:0043025; GO:0007097; GO:0072384; GO:0005886; GO:0045740; GO:0046330; GO:0032467; GO:0010628; GO:0071338; GO:0090316; GO:0048554; GO:0043525; GO:0033138; GO:0043552; GO:0031274; GO:1900026; GO:0051835; GO:0051988; GO:0017157; GO:0051489; GO:0007088; GO:0042176; GO:0043497; GO:0045859; GO:0031647; GO:0009749; GO:0030141; GO:0007264; GO:0051233; GO:0002040; GO:0060661 Q9UQB8 GTP binding; GTPase activity; Golgi membrane; Golgi organization; actin filament branching; actin filament bundle assembly; adherens junction organization; apical part of cell; canonical Wnt receptor signaling pathway; cardiac conduction system development; cellular protein localization; cytosol; epithelial cell-cell adhesion; epithelial-mesenchymal cell signaling; establishment of Golgi localization; establishment of cell polarity; establishment or maintenance of apical/basal cell polarity; filopodium; filopodium assembly; hair follicle morphogenesis; hair follicle placode formation; heart contraction; keratinization; keratinocyte development; microtubule organizing center; midbody; mitotic spindle; multicellular organism growth; negative regulation of gene expression; negative regulation of protein complex assembly; neuron fate determination; neuron projection; neuronal cell body; nuclear migration; organelle transport along microtubule; plasma membrane; positive regulation of DNA replication; positive regulation of JNK cascade; positive regulation of cytokinesis; positive regulation of gene expression; positive regulation of hair follicle cell proliferation; positive regulation of intracellular protein transport; positive regulation of metalloenzyme activity; positive regulation of neuron apoptotic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of pseudopodium assembly; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of synapse structural plasticity; regulation of attachment of spindle microtubules to kinetochore; regulation of exocytosis; regulation of filopodium assembly; regulation of mitosis; regulation of protein catabolic process; regulation of protein heterodimerization activity; regulation of protein kinase activity; regulation of protein stability; response to glucose stimulus; secretory granule; small GTPase mediated signal transduction; spindle midzone; sprouting angiogenesis; submandibular salivary gland formation IPR027417; IPR005225; IPR001806; IPR003578; Cell division control protein 42 homolog Cdc42 Rattus norvegicus (Rat) TR40033_c0_g1_i9 Q01112 CDC42_SCHPO 5.00E-39 GO:0071521; GO:0032488; GO:0005525; GO:0003924; GO:0051285; GO:0007049; GO:0051301; GO:0032153; GO:0005829; GO:0030950; GO:0035838; GO:0009898; GO:0005634; GO:0032955; GO:0032951; GO:0031137; GO:2000769; GO:0017157 Q09763; Q9UUM7 Cdc42 GTPase complex; Cdc42 protein signal transduction; GTP binding; GTPase activity; cell cortex of cell tip; cell cycle; cell division; cell division site; cytosol; establishment or maintenance of actin cytoskeleton polarity; growing cell tip; internal side of plasma membrane; nucleus; regulation of barrier septum assembly; regulation of beta-glucan biosynthetic process; regulation of conjugation with cellular fusion; regulation of establishment or maintenance of cell polarity regulating cell shape; regulation of exocytosis IPR027417; IPR005225; IPR001806; IPR003578; Cell division control protein 42 homolog (CDC42Sp) cdc42 SPAC110.03 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40034_c0_g1_i3 Q80TM6 R3HD2_MOUSE 3.00E-42 GO:0003676; GO:0005634 nucleic acid binding; nucleus IPR001374; IPR024771; R3H domain-containing protein 2 R3hdm2 Kiaa1002 Mus musculus (Mouse) TR40034_c0_g1_i4 Q80TM6 R3HD2_MOUSE 5.00E-42 GO:0003676; GO:0005634 nucleic acid binding; nucleus IPR001374; IPR024771; R3H domain-containing protein 2 R3hdm2 Kiaa1002 Mus musculus (Mouse) TR40036_c0_g1_i1 P04323 POL3_DROME 4.00E-30 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR40036_c0_g1_i2 Q09575 YRD6_CAEEL 2.00E-30 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR40036_c0_g1_i3 P31623 POL_JSRV 3.00E-07 GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0075713; GO:0090305; GO:0004523; GO:0046718; GO:0008270 DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; establishment of integrated proviral latency; nucleic acid phosphodiester bond hydrolysis; ribonuclease H activity; viral entry into host cell; zinc ion binding IPR001037; IPR001584; IPR017856; IPR003308; IPR012337; IPR002156; IPR000477; IPR010661; Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN)] pol Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV) TR40036_c0_g1_i4 P04323 POL3_DROME 2.00E-29 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR40036_c0_g1_i6 P03554 POL_CAMVS 4.00E-23 GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR000588; IPR000477; Enzymatic polyprotein [Includes: Aspartic protease (EC 3.4.23.-); Endonuclease; Reverse transcriptase (EC 2.7.7.49)] ORF V Cauliflower mosaic virus (strain Strasbourg) (CaMV) TR40036_c0_g1_i7 Q09575 YRD6_CAEEL 7.00E-32 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR40037_c0_g2_i2 Q64441 CP24A_MOUSE 2.00E-46 GO:0030342; GO:0008403; GO:0020037; GO:0005506; GO:0005739; GO:0001649; GO:0033280; GO:0042359 "1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; heme binding; iron ion binding; mitochondrion; osteoblast differentiation; response to vitamin D; vitamin D metabolic process" IPR001128; IPR017972; IPR002401; "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.13.126) (Cytochrome P450 24A1) (Cytochrome P450-CC24)" Cyp24a1 Cyp-24 Cyp24 Mus musculus (Mouse) TR40037_c0_g2_i4 Q64441 CP24A_MOUSE 2.00E-46 GO:0030342; GO:0008403; GO:0020037; GO:0005506; GO:0005739; GO:0001649; GO:0033280; GO:0042359 "1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; heme binding; iron ion binding; mitochondrion; osteoblast differentiation; response to vitamin D; vitamin D metabolic process" IPR001128; IPR017972; IPR002401; "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.13.126) (Cytochrome P450 24A1) (Cytochrome P450-CC24)" Cyp24a1 Cyp-24 Cyp24 Mus musculus (Mouse) TR40038_c3_g3_i3 Q9UMY4 SNX12_HUMAN 4.00E-68 GO:0007154; GO:0016020; GO:0035091; GO:0015031 P16333 cell communication; membrane; phosphatidylinositol binding; protein transport IPR001683; Sorting nexin-12 SNX12 Homo sapiens (Human) TR40038_c3_g3_i6 Q9UMY4 SNX12_HUMAN 5.00E-68 GO:0007154; GO:0016020; GO:0035091; GO:0015031 P16333 cell communication; membrane; phosphatidylinositol binding; protein transport IPR001683; Sorting nexin-12 SNX12 Homo sapiens (Human) TR40039_c1_g1_i1 P38445 AVR2B_RAT 5.00E-32 GO:0005524; GO:0030509; GO:0032147; GO:0048185; GO:0009952; GO:0060840; GO:0001974; GO:0009986; GO:0005737; GO:0007368; GO:0048617; GO:0001702; GO:0007507; GO:0034711; GO:0030073; GO:0016021; GO:0001822; GO:0030324; GO:0001946; GO:0060836; GO:0007498; GO:0046872; GO:0042475; GO:0035265; GO:0060021; GO:0031016; GO:0005886; GO:0032927; GO:0030501; GO:0045669; GO:0009791; GO:0004712; GO:0004702; GO:0009749; GO:0061298; GO:0019953; GO:0023014; GO:0048705; GO:0005024; GO:0004675; GO:0060841 ATP binding; BMP signaling pathway; activation of protein kinase activity; activin binding; anterior/posterior pattern specification; artery development; blood vessel remodeling; cell surface; cytoplasm; determination of left/right symmetry; embryonic foregut morphogenesis; gastrulation with mouth forming second; heart development; inhibin binding; insulin secretion; integral to membrane; kidney development; lung development; lymphangiogenesis; lymphatic endothelial cell differentiation; mesoderm development; metal ion binding; odontogenesis of dentin-containing tooth; organ growth; palate development; pancreas development; plasma membrane; positive regulation of activin receptor signaling pathway; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; post-embryonic development; protein serine/threonine/tyrosine kinase activity; receptor signaling protein serine/threonine kinase activity; response to glucose stimulus; retina vasculature development in camera-type eye; sexual reproduction; signal transduction by phosphorylation; skeletal system morphogenesis; transforming growth factor beta-activated receptor activity; transmembrane receptor protein serine/threonine kinase activity; venous blood vessel development IPR000472; IPR011009; IPR000719; IPR008271; IPR000333; Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB) Acvr2b Actriib Rattus norvegicus (Rat) TR40039_c1_g3_i1 Q13873 BMPR2_HUMAN 1.00E-49 GO:0005524; GO:0030509; GO:0016362; GO:0009952; GO:0060840; GO:0001974; GO:0009986; GO:0009267; GO:0005887; GO:0048286; GO:0001946; GO:0060836; GO:0001707; GO:0046872; GO:2000279; GO:0030308; GO:0003085; GO:0045906; GO:0030513; GO:0030501; GO:0010595; GO:0001938; GO:0045669; GO:0010862; GO:0014916; GO:0061298; GO:0006366; GO:0005024; GO:0048010; GO:0060841 P08607; P43026; P68404; Q13976 "ATP binding; BMP signaling pathway; activin receptor activity, type II; anterior/posterior pattern specification; artery development; blood vessel remodeling; cell surface; cellular response to starvation; integral to plasma membrane; lung alveolus development; lymphangiogenesis; lymphatic endothelial cell differentiation; mesoderm formation; metal ion binding; negative regulation of DNA biosynthetic process; negative regulation of cell growth; negative regulation of systemic arterial blood pressure; negative regulation of vasoconstriction; positive regulation of BMP signaling pathway; positive regulation of bone mineralization; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of osteoblast differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; regulation of lung blood pressure; retina vasculature development in camera-type eye; transcription from RNA polymerase II promoter; transforming growth factor beta-activated receptor activity; vascular endothelial growth factor receptor signaling pathway; venous blood vessel development" IPR000472; IPR015770; IPR011009; IPR000719; IPR017441; Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) BMPR2 PPH1 Homo sapiens (Human) TR40039_c1_g3_i2 Q13873 BMPR2_HUMAN 9.00E-50 GO:0005524; GO:0030509; GO:0016362; GO:0009952; GO:0060840; GO:0001974; GO:0009986; GO:0009267; GO:0005887; GO:0048286; GO:0001946; GO:0060836; GO:0001707; GO:0046872; GO:2000279; GO:0030308; GO:0003085; GO:0045906; GO:0030513; GO:0030501; GO:0010595; GO:0001938; GO:0045669; GO:0010862; GO:0014916; GO:0061298; GO:0006366; GO:0005024; GO:0048010; GO:0060841 P08607; P43026; P68404; Q13976 "ATP binding; BMP signaling pathway; activin receptor activity, type II; anterior/posterior pattern specification; artery development; blood vessel remodeling; cell surface; cellular response to starvation; integral to plasma membrane; lung alveolus development; lymphangiogenesis; lymphatic endothelial cell differentiation; mesoderm formation; metal ion binding; negative regulation of DNA biosynthetic process; negative regulation of cell growth; negative regulation of systemic arterial blood pressure; negative regulation of vasoconstriction; positive regulation of BMP signaling pathway; positive regulation of bone mineralization; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of osteoblast differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; regulation of lung blood pressure; retina vasculature development in camera-type eye; transcription from RNA polymerase II promoter; transforming growth factor beta-activated receptor activity; vascular endothelial growth factor receptor signaling pathway; venous blood vessel development" IPR000472; IPR015770; IPR011009; IPR000719; IPR017441; Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) BMPR2 PPH1 Homo sapiens (Human) TR40040_c1_g2_i1 Q03QS9 DPO3_LACBA 7.00E-06 GO:0008408; GO:0003677; GO:0006260; GO:0003887; GO:0005737; GO:0090305 3'-5' exonuclease activity; DNA binding; DNA replication; DNA-directed DNA polymerase activity; cytoplasm; nucleic acid phosphodiester bond hydrolysis IPR011708; IPR028112; IPR024754; IPR006054; IPR006055; IPR013520; IPR012340; IPR004365; IPR004013; IPR003141; IPR006308; IPR012337; DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC LVIS_1341 Lactobacillus brevis (strain ATCC 367 / JCM 1170) TR40040_c2_g1_i1 P17710 HXK1_MOUSE 2.00E-27 GO:0005524; GO:0001678; GO:0005829; GO:0008865; GO:0004340; GO:0006096; GO:0019158; GO:0045121; GO:0005741; GO:0005739 ATP binding; cellular glucose homeostasis; cytosol; fructokinase activity; glucokinase activity; glycolysis; mannokinase activity; membrane raft; mitochondrial outer membrane; mitochondrion IPR001312; IPR022673; IPR019807; IPR022672; Carbohydrate metabolism; hexose metabolism. "Hexokinase-1 (EC 2.7.1.1) (Hexokinase type I) (HK I) (Hexokinase, tumor isozyme)" Hk1 Mus musculus (Mouse) TR40040_c2_g1_i3 P35557 HXK4_HUMAN 1.00E-30 GO:0043531; GO:0005524; GO:0006739; GO:0070509; GO:0005938; GO:0001678; GO:0042149; GO:0032869; GO:0044320; GO:0005829; GO:0051594; GO:0007204; GO:0031018; GO:0006003; GO:0004340; GO:0005536; GO:0015758; GO:0005978; GO:0006096; GO:0000287; GO:0005739; GO:0032811; GO:0045721; GO:0005654; GO:0045725; GO:0045821; GO:0032024; GO:0042327; GO:0010827; GO:0006110; GO:0043266; GO:0019932; GO:0030141; GO:0044281; GO:0055085 Q14397; P16118 "ADP binding; ATP binding; NADP metabolic process; calcium ion import; cell cortex; cellular glucose homeostasis; cellular response to glucose starvation; cellular response to insulin stimulus; cellular response to leptin stimulus; cytosol; detection of glucose; elevation of cytosolic calcium ion concentration; endocrine pancreas development; fructose 2,6-bisphosphate metabolic process; glucokinase activity; glucose binding; glucose transport; glycogen biosynthetic process; glycolysis; magnesium ion binding; mitochondrion; negative regulation of epinephrine secretion; negative regulation of gluconeogenesis; nucleoplasm; positive regulation of glycogen biosynthetic process; positive regulation of glycolysis; positive regulation of insulin secretion; positive regulation of phosphorylation; regulation of glucose transport; regulation of glycolysis; regulation of potassium ion transport; second-messenger-mediated signaling; secretory granule; small molecule metabolic process; transmembrane transport" IPR001312; IPR022673; IPR019807; IPR022672; Glucokinase (EC 2.7.1.2) (Hexokinase type IV) (HK IV) (Hexokinase-4) (HK4) (Hexokinase-D) GCK Homo sapiens (Human) TR40040_c2_g2_i2 Q9NFT7 HXK2_DROME 2.00E-104 GO:0005524; GO:0001678; GO:0005829; GO:0008865; GO:0004340; GO:0006096; GO:0019158 ATP binding; cellular glucose homeostasis; cytosol; fructokinase activity; glucokinase activity; glycolysis; mannokinase activity IPR001312; IPR022673; IPR019807; IPR022672; Carbohydrate metabolism; hexose metabolism. Hexokinase type 2 (EC 2.7.1.1) Hex-t2 Hex CG32849 Drosophila melanogaster (Fruit fly) TR40041_c0_g1_i1 Q54KA7 SECG_DICDI 3.00E-13 GO:0005086; GO:0031589; GO:0006935; GO:0005829; GO:0005764; GO:0005543; GO:0032012 ARF guanyl-nucleotide exchange factor activity; cell-substrate adhesion; chemotaxis; cytosol; lysosome; phospholipid binding; regulation of ARF protein signal transduction IPR002110; IPR020683; IPR011993; IPR001849; IPR023394; IPR000904; "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) TR40041_c0_g2_i1 Q02357 ANK1_MOUSE 4.00E-12 GO:0030863; GO:0048821; GO:0016020; GO:0015672; GO:0006779; GO:0016529; GO:0007165; GO:0014731 cortical cytoskeleton; erythrocyte development; membrane; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; sarcoplasmic reticulum; signal transduction; spectrin-associated cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) TR40041_c4_g1_i1 P16157 ANK1_HUMAN 3.00E-13 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR40042_c5_g2_i1 P38766 RRM3_YEAST 2.00E-20 GO:0005524; GO:0004003; GO:0003677; GO:0006281; GO:0006260; GO:0000002; GO:0005724; GO:0005657; GO:0097046; GO:0000723 ATP binding; ATP-dependent DNA helicase activity; DNA binding; DNA repair; DNA replication; mitochondrial genome maintenance; nuclear telomeric heterochromatin; replication fork; replication fork progression beyond termination site; telomere maintenance IPR003593; IPR010285; IPR027417; ATP-dependent DNA helicase RRM3 (EC 3.6.4.12) (Regulation of Ty1 transposition protein 104) (rDNA recombination mutation protein 3) RRM3 RTT104 YHR031C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40043_c2_g1_i10 Q7RTY1 MOT9_HUMAN 9.00E-21 GO:0016021; GO:0005886; GO:0015293; GO:0046415 integral to membrane; plasma membrane; symporter activity; urate metabolic process IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 C10orf36 MCT9 Homo sapiens (Human) TR40043_c2_g1_i2 A1L1W9 MOT10_DANRE 1.00E-09 GO:0016021; GO:0005886; GO:0055085 integral to membrane; plasma membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 10 (MCT 10) (Solute carrier family 16 member 10) slc16a10 si:ch211-241j12.1 zgc:158478 Danio rerio (Zebrafish) (Brachydanio rerio) TR40043_c2_g1_i3 O15403 MOT7_HUMAN 4.00E-17 GO:0005887; GO:0008028; GO:0015293 integral to plasma membrane; monocarboxylic acid transmembrane transporter activity; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 7 (MCT 7) (Monocarboxylate transporter 6) (MCT 6) (Solute carrier family 16 member 6) SLC16A6 MCT6 MCT7 Homo sapiens (Human) TR40043_c2_g1_i5 Q503M4 MT12B_DANRE 7.00E-16 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12-B (MCT 12-B) (Solute carrier family 16 member 12-B) slc16a12b slc16a12 zgc:110441 Danio rerio (Zebrafish) (Brachydanio rerio) TR40043_c2_g1_i6 Q7RTY1 MOT9_HUMAN 7.00E-23 GO:0016021; GO:0005886; GO:0015293; GO:0046415 integral to membrane; plasma membrane; symporter activity; urate metabolic process IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 C10orf36 MCT9 Homo sapiens (Human) TR40043_c2_g1_i9 Q503M4 MT12B_DANRE 1.00E-14 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12-B (MCT 12-B) (Solute carrier family 16 member 12-B) slc16a12b slc16a12 zgc:110441 Danio rerio (Zebrafish) (Brachydanio rerio) TR40045_c0_g2_i1 Q6GR45 IF6_XENLA 1.00E-155 GO:0005737; GO:0042256; GO:0005730; GO:0043022; GO:0003743 cytoplasm; mature ribosome assembly; nucleolus; ribosome binding; translation initiation factor activity IPR002769; Eukaryotic translation initiation factor 6 (eIF-6) eif6 Xenopus laevis (African clawed frog) TR40046_c5_g3_i1 P25323 MYLKA_DICDI 6.00E-57 GO:0005524; GO:0030898; GO:0019933; GO:0019934; GO:0005737; GO:0000281; GO:0004687; GO:0046777; GO:0050920 ATP binding; actin-dependent ATPase activity; cAMP-mediated signaling; cGMP-mediated signaling; cytoplasm; mitotic cytokinesis; myosin light chain kinase activity; protein autophosphorylation; regulation of chemotaxis IPR020636; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Myosin light chain kinase A (MLCK-A) (EC 2.7.11.18) mlkA DDB_G0279925 Dictyostelium discoideum (Slime mold) TR40046_c5_g3_i11 Q03533 TDA1_YEAST 8.00E-11 GO:0005524; GO:0005737; GO:0005634; GO:0004672; GO:0004674 ATP binding; cytoplasm; nucleus; protein kinase activity; protein serine/threonine kinase activity IPR011009; IPR020675; IPR000719; IPR017441; IPR002290; IPR008271; IPR020679; Serine/threonine-protein kinase TDA1 (Topoisomerase I damage affected protein 1) (EC 2.7.11.1) TDA1 YMR291W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40046_c5_g3_i12 P34722 KPC1_CAEEL 2.00E-23 GO:0005524; GO:0035556; GO:0046872; GO:0004697 ATP binding; intracellular signal transduction; metal ion binding; protein kinase C activity IPR000961; IPR000008; IPR020454; IPR011009; IPR017892; IPR014376; IPR002219; IPR000719; IPR017441; IPR002290; IPR008271; Protein kinase C-like 1 (PKC) (EC 2.7.11.13) (Tetradecanoyl phorbol acetate-resistant protein 1) tpa-1 B0545.1 Caenorhabditis elegans TR40046_c5_g3_i2 Q16816 PHKG1_HUMAN 4.00E-126 GO:0005524; GO:0005829; GO:0006006; GO:0005978; GO:0005980; GO:0004689; GO:0005964; GO:0044281; GO:0050321 ATP binding; cytosol; glucose metabolic process; glycogen biosynthetic process; glycogen catabolic process; phosphorylase kinase activity; phosphorylase kinase complex; small molecule metabolic process; tau-protein kinase activity IPR020636; IPR011009; IPR002291; IPR000719; IPR017441; IPR002290; IPR008271; "Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1) (EC 2.7.11.26)" PHKG1 PHKG Homo sapiens (Human) TR40046_c5_g3_i4 Q63638 SPEG_RAT 2.00E-23 GO:0005524; GO:0042692; GO:0005634; GO:0004674 ATP binding; muscle cell differentiation; nucleus; protein serine/threonine kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Striated muscle-specific serine/threonine-protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Speg Apeg1 Rattus norvegicus (Rat) TR40046_c5_g3_i5 P25323 MYLKA_DICDI 5.00E-57 GO:0005524; GO:0030898; GO:0019933; GO:0019934; GO:0005737; GO:0000281; GO:0004687; GO:0046777; GO:0050920 ATP binding; actin-dependent ATPase activity; cAMP-mediated signaling; cGMP-mediated signaling; cytoplasm; mitotic cytokinesis; myosin light chain kinase activity; protein autophosphorylation; regulation of chemotaxis IPR020636; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Myosin light chain kinase A (MLCK-A) (EC 2.7.11.18) mlkA DDB_G0279925 Dictyostelium discoideum (Slime mold) TR40046_c5_g3_i6 Q696W0 SPEG_DANRE 1.00E-25 GO:0005524; GO:0030018; GO:0007517; GO:0005634; GO:0004672; GO:0004674 ATP binding; Z disc; muscle organ development; nucleus; protein kinase activity; protein serine/threonine kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR020675; IPR000719; IPR017441; IPR002290; IPR015726; IPR008271; Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) speg apeg1 Danio rerio (Zebrafish) (Brachydanio rerio) TR40046_c5_g3_i7 Q16816 PHKG1_HUMAN 4.00E-126 GO:0005524; GO:0005829; GO:0006006; GO:0005978; GO:0005980; GO:0004689; GO:0005964; GO:0044281; GO:0050321 ATP binding; cytosol; glucose metabolic process; glycogen biosynthetic process; glycogen catabolic process; phosphorylase kinase activity; phosphorylase kinase complex; small molecule metabolic process; tau-protein kinase activity IPR020636; IPR011009; IPR002291; IPR000719; IPR017441; IPR002290; IPR008271; "Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1) (EC 2.7.11.26)" PHKG1 PHKG Homo sapiens (Human) TR40046_c5_g3_i8 Q16816 PHKG1_HUMAN 3.00E-126 GO:0005524; GO:0005829; GO:0006006; GO:0005978; GO:0005980; GO:0004689; GO:0005964; GO:0044281; GO:0050321 ATP binding; cytosol; glucose metabolic process; glycogen biosynthetic process; glycogen catabolic process; phosphorylase kinase activity; phosphorylase kinase complex; small molecule metabolic process; tau-protein kinase activity IPR020636; IPR011009; IPR002291; IPR000719; IPR017441; IPR002290; IPR008271; "Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1) (EC 2.7.11.26)" PHKG1 PHKG Homo sapiens (Human) TR40046_c5_g3_i9 Q751E8 PHO85_ASHGO 5.00E-21 GO:0005524; GO:0004693 ATP binding; cyclin-dependent protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Negative regulator of the PHO system (EC 2.7.11.22) (Serine/threonine-protein kinase PHO85) PHO85 AGL242C Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR40047_c0_g2_i1 Q03577 SYDC_CAEEL 0 GO:0005524; GO:0004815; GO:0006422; GO:0005737; GO:0003676 ATP binding; aspartate-tRNA ligase activity; aspartyl-tRNA aminoacylation; cytoplasm; nucleic acid binding IPR004364; IPR018150; IPR006195; IPR004523; IPR002312; IPR012340; IPR004365; "Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS)" drs-1 B0464.1 Caenorhabditis elegans TR40047_c0_g2_i2 Q75JQ1 SYDC1_DICDI 3.00E-154 GO:0005524; GO:0004815; GO:0006422; GO:0003676; GO:0045335; GO:0009617 ATP binding; aspartate-tRNA ligase activity; aspartyl-tRNA aminoacylation; nucleic acid binding; phagocytic vesicle; response to bacterium IPR004364; IPR018150; IPR006195; IPR004523; IPR002312; IPR012340; IPR004365; "Aspartate--tRNA ligase, cytoplasmic 1 (EC 6.1.1.12) (Aspartyl-tRNA synthetase 1) (AspRS 1)" aspS1 DDB_G0272236 Dictyostelium discoideum (Slime mold) TR40047_c0_g2_i3 O84546 SYD_CHLTR 1.00E-14 GO:0005524; GO:0004815; GO:0006422; GO:0005737; GO:0003676 ATP binding; aspartate-tRNA ligase activity; aspartyl-tRNA aminoacylation; cytoplasm; nucleic acid binding IPR004364; IPR018150; IPR006195; IPR004524; IPR002312; IPR004115; IPR012340; IPR004365; Aspartate--tRNA ligase (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) aspS CT_542 Chlamydia trachomatis (strain D/UW-3/Cx) TR40047_c0_g2_i4 Q922B2 SYDC_MOUSE 0 GO:0005524; GO:0004815; GO:0006422; GO:0005737; GO:0003676 ATP binding; aspartate-tRNA ligase activity; aspartyl-tRNA aminoacylation; cytoplasm; nucleic acid binding IPR004364; IPR018150; IPR006195; IPR004523; IPR002312; IPR012340; IPR004365; "Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS)" Dars Mus musculus (Mouse) TR40047_c0_g2_i5 A5D5Q4 SYK_PELTS 5.00E-08 GO:0005524; GO:0005737; GO:0004824; GO:0006430; GO:0000287; GO:0003676 ATP binding; cytoplasm; lysine-tRNA ligase activity; lysyl-tRNA aminoacylation; magnesium ion binding; nucleic acid binding IPR004364; IPR018150; IPR006195; IPR002313; IPR018149; IPR012340; IPR004365; Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) lysS PTH_0263 Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI) TR40048_c1_g1_i1 Q8BZK4 S35F4_MOUSE 5.00E-14 GO:0016021; GO:0006810 integral to membrane; transport IPR026505; Solute carrier family 35 member F4 Slc35f4 MNCb-0335 Mus musculus (Mouse) TR40049_c0_g1_i1 Q8R143 PTTG_MOUSE 2.00E-18 GO:0005737; GO:0016021; GO:0007275; GO:0005634; GO:0005886; GO:0006606; GO:0004872 cytoplasm; integral to membrane; multicellular organismal development; nucleus; plasma membrane; protein import into nucleus; receptor activity IPR016201; Pituitary tumor-transforming gene 1 protein-interacting protein (Pituitary tumor-transforming gene protein-binding factor) (PBF) (PTTG-binding factor) Pttg1ip Mus musculus (Mouse) TR40051_c0_g3_i2 Q9UGT4 SUSD2_HUMAN 2.00E-57 GO:0006955; GO:0016021; GO:0030247; GO:0005044 immune response; integral to membrane; polysaccharide binding; scavenger receptor activity IPR005533; IPR001212; IPR000436; IPR001846; Sushi domain-containing protein 2 SUSD2 Homo sapiens (Human) TR40051_c0_g3_i3 Q5ZQU0 SNED1_RAT 2.00E-51 GO:0005509; GO:0007160; GO:0005576 calcium ion binding; cell-matrix adhesion; extracellular region IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003961; IPR009030; IPR013783; IPR003886; IPR000436; "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" Sned1 Rattus norvegicus (Rat) TR40051_c0_g5_i1 O75443 TECTA_HUMAN 3.00E-50 GO:0031225; GO:0007160; GO:0005201; GO:0005886; GO:0005578; GO:0007605 anchored to membrane; cell-matrix adhesion; extracellular matrix structural constituent; plasma membrane; proteinaceous extracellular matrix; sensory perception of sound IPR000742; IPR003886; IPR002919; IPR025615; IPR014853; IPR006552; IPR001007; IPR001846; IPR001507; IPR017977; Alpha-tectorin TECTA Homo sapiens (Human) TR40053_c0_g1_i1 Q3ZBH0 TCPB_BOVIN 0 GO:0005524; GO:0007339; GO:0051131; GO:0005832; GO:0005874; GO:0005634; GO:0006457; GO:0002199 ATP binding; binding of sperm to zona pellucida; chaperone-mediated protein complex assembly; chaperonin-containing T-complex; microtubule; nucleus; protein folding; zona pellucida receptor complex IPR012716; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta) CCT2 Bos taurus (Bovine) TR40055_c1_g2_i2 Q5R541 GEM_PONAB 1.00E-19 GO:0005525; GO:0003924; GO:0005886; GO:0007264 GTP binding; GTPase activity; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR017358; IPR020849; GTP-binding protein GEM GEM Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40055_c1_g2_i6 Q5R541 GEM_PONAB 2.00E-25 GO:0005525; GO:0003924; GO:0005886; GO:0007264 GTP binding; GTPase activity; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR017358; IPR020849; GTP-binding protein GEM GEM Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40056_c0_g2_i2 O43402 EMC8_HUMAN 2.00E-45 GO:0072546; GO:0005739; GO:0005634 ER membrane protein complex; mitochondrion; nucleus IPR005366; ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B) EMC8 C16orf2 C16orf4 COX4AL COX4NB FAM158B NOC4 Homo sapiens (Human) TR40059_c0_g1_i1 Q5E951 TBCB_BOVIN 2.00E-38 GO:0030154; GO:0005829; GO:0005874; GO:0007399; GO:0007023 cell differentiation; cytosol; microtubule; nervous system development; post-chaperonin tubulin folding pathway IPR000938; IPR027933; Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B) TBCB CKAP1 Bos taurus (Bovine) TR40059_c0_g1_i5 P13496 DCTN1_DROME 2.00E-12 GO:0005818; GO:0001709; GO:0051299; GO:0005737; GO:0005869; GO:0045502; GO:0030286; GO:0045198; GO:0006886; GO:0000776; GO:0005828; GO:0051383; GO:0051028; GO:0035011; GO:0035371; GO:0030496; GO:0047497; GO:0003774; GO:0048477; GO:0034501; GO:0008090; GO:0042052; GO:0016330; GO:0051256; GO:0031616 aster; cell fate determination; centrosome separation; cytoplasm; dynactin complex; dynein binding; dynein complex; establishment of epithelial cell apical/basal polarity; intracellular protein transport; kinetochore; kinetochore microtubule; kinetochore organization; mRNA transport; melanotic encapsulation of foreign target; microtubule plus end; midbody; mitochondrion transport along microtubule; motor activity; oogenesis; protein localization to kinetochore; retrograde axon cargo transport; rhabdomere development; second mitotic wave involved in compound eye morphogenesis; spindle midzone assembly involved in mitosis; spindle pole centrosome IPR000938; IPR027663; IPR022157; Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (Protein glued) Gl CG9206 Drosophila melanogaster (Fruit fly) TR40059_c0_g3_i3 Q5E951 TBCB_BOVIN 1.00E-77 GO:0030154; GO:0005829; GO:0005874; GO:0007399; GO:0007023 cell differentiation; cytosol; microtubule; nervous system development; post-chaperonin tubulin folding pathway IPR000938; IPR027933; Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B) TBCB CKAP1 Bos taurus (Bovine) TR40060_c0_g1_i1 P83917 CBX1_MOUSE 8.00E-44 GO:0005721; GO:0010369; GO:0001939; GO:0001940; GO:0045892; GO:0005819 Itself; Q9QWF0; P68433; Q64127 "centromeric heterochromatin; chromocenter; female pronucleus; male pronucleus; negative regulation of transcription, DNA-dependent; spindle" IPR017984; IPR023780; IPR000953; IPR008251; IPR016197; IPR023779; Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) Cbx1 Cbx Mus musculus (Mouse) TR40060_c0_g1_i2 Q5R6X7 CBX3_PONAB 3.00E-49 GO:0016568; GO:0000779; GO:0045892; GO:0031618; GO:0005635; GO:0005719; GO:0019904; GO:0005819; GO:0006351 "chromatin modification; condensed chromosome, centromeric region; negative regulation of transcription, DNA-dependent; nuclear centromeric heterochromatin; nuclear envelope; nuclear euchromatin; protein domain specific binding; spindle; transcription, DNA-dependent" IPR017984; IPR023780; IPR000953; IPR008251; IPR016197; IPR023779; Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) CBX3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40060_c0_g1_i3 P45973 CBX5_HUMAN 1.00E-43 GO:0007596; GO:0003682; GO:0010369; GO:0005737; GO:0000118; GO:0035097; GO:0000776; GO:0035064; GO:0019048; GO:0045892; GO:0031618; GO:0005635; GO:0005730; GO:0030674; GO:0070491; GO:0017053 Q9H2P0; Q8IXJ9; P59598; Q13111; P84243; P68431; Q9NQS7; Q14739; Q9UIS9; Q7Z3K3; O43463; Q13263 "blood coagulation; chromatin binding; chromocenter; cytoplasm; histone deacetylase complex; histone methyltransferase complex; kinetochore; methylated histone residue binding; modulation by virus of host morphology or physiology; negative regulation of transcription, DNA-dependent; nuclear centromeric heterochromatin; nuclear envelope; nucleolus; protein binding, bridging; repressing transcription factor binding; transcriptional repressor complex" IPR017984; IPR023780; IPR000953; IPR008251; IPR016197; IPR023779; Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha) CBX5 HP1A Homo sapiens (Human) TR40061_c2_g2_i1 Q9ULW3 ABT1_HUMAN 4.00E-43 GO:0003677; GO:0003723; GO:0005730; GO:0000166; GO:0005634; GO:0006357; GO:0021522; GO:0003713; GO:0005667; GO:0006366 DNA binding; RNA binding; nucleolus; nucleotide binding; nucleus; regulation of transcription from RNA polymerase II promoter; spinal cord motor neuron differentiation; transcription coactivator activity; transcription factor complex; transcription from RNA polymerase II promoter IPR012677; Activator of basal transcription 1 (hABT1) (Basal transcriptional activator) ABT1 Homo sapiens (Human) TR40061_c2_g2_i2 P0CL96 ESF2_CRYNJ 4.00E-41 GO:0003723; GO:0005730; GO:0000166; GO:0006364 RNA binding; nucleolus; nucleotide binding; rRNA processing IPR012677; Pre-rRNA-processing protein ESF2 (18S rRNA factor 2) ESF2 CNB00450 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR40061_c2_g2_i3 Q2GZQ4 ESF2_CHAGB 3.00E-37 GO:0003723; GO:0005730; GO:0000166; GO:0006364 RNA binding; nucleolus; nucleotide binding; rRNA processing IPR012677; IPR000504; Pre-rRNA-processing protein ESF2 (18S rRNA factor 2) ESF2 CHGG_04992 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) TR40061_c2_g2_i5 Q5R9Y3 ABT1_PONAB 3.00E-43 GO:0003677; GO:0003723; GO:0005730; GO:0000166; GO:0006355; GO:0006351 "DNA binding; RNA binding; nucleolus; nucleotide binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR012677; Activator of basal transcription 1 ABT1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40061_c3_g2_i2 Q5EBF8 ATRAP_XENTR 4.00E-17 GO:0016021 integral to membrane IPR009436; Type-1 angiotensin II receptor-associated protein-like agtrap TGas011p03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40061_c3_g2_i3 Q5RER2 ATRAP_PONAB 6.00E-13 GO:0000139; GO:0004945; GO:0005938; GO:0030659; GO:0005789; GO:0016021; GO:0005886; GO:0008217 Golgi membrane; angiotensin type II receptor activity; cell cortex; cytoplasmic vesicle membrane; endoplasmic reticulum membrane; integral to membrane; plasma membrane; regulation of blood pressure IPR009436; Type-1 angiotensin II receptor-associated protein (AT1 receptor-associated protein) AGTRAP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40061_c3_g3_i3 Q96MB7 HARB1_HUMAN 1.00E-34 GO:0005813; GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 centrosome; cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) HARBI1 C11orf77 Homo sapiens (Human) TR40062_c0_g1_i2 Q4V9Y0 VPS51_XENTR 3.00E-177 GO:0005794; GO:0006869; GO:0015031 Golgi apparatus; lipid transport; protein transport IPR016159; Vacuolar protein sorting-associated protein 51 homolog (Protein fat-free homolog) vps51 ffr Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40063_c2_g2_i1 Q9H9B1 EHMT1_HUMAN 0 GO:0006306; GO:0005694; GO:0009790; GO:0046976; GO:0046974; GO:0000122; GO:0045892; GO:0005634; GO:0018027; GO:0018026; GO:0008270 Q99549; Q04206; Q04207 "DNA methylation; chromosome; embryo development; histone methyltransferase activity (H3-K27 specific); histone methyltransferase activity (H3-K9 specific); negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; peptidyl-lysine dimethylation; peptidyl-lysine monomethylation; zinc ion binding" IPR002110; IPR020683; IPR007728; IPR003606; IPR001214; Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) EHMT1 EUHMTASE1 GLP KIAA1876 KMT1D Homo sapiens (Human) TR40064_c2_g3_i1 Q91WE2 F192A_MOUSE 1.00E-23 GO:0005634 nucleus IPR019331; Protein FAM192A (NEFA-interacting nuclear protein NIP30) Fam192a Nip30 Mus musculus (Mouse) TR40065_c0_g1_i1 P97872 FMO5_MOUSE 0 GO:0004499; GO:0050661; GO:0005789; GO:0050660; GO:0016021 "N,N-dimethylaniline monooxygenase activity; NADP binding; endoplasmic reticulum membrane; flavin adenine dinucleotide binding; integral to membrane" IPR012143; IPR000960; IPR020946; IPR002257; IPR016040; Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5) Fmo5 Mus musculus (Mouse) TR40065_c1_g2_i10 Q5RFZ7 F167A_DANRE 1.00E-08 IPR024280; Protein FAM167A fam167a si:ch211-261f7.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR40065_c1_g2_i6 Q5RFZ7 F167A_DANRE 1.00E-08 IPR024280; Protein FAM167A fam167a si:ch211-261f7.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR40066_c3_g1_i2 P48304 REG1B_HUMAN 3.00E-10 GO:0030246; GO:0008283; GO:0005576 carbohydrate binding; cell proliferation; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Lithostathine-1-beta (Pancreatic stone protein 2) (PSP-2) (Regenerating islet-derived protein 1-beta) (REG-1-beta) (Regenerating protein I beta) REG1B PSPS2 REGL Homo sapiens (Human) TR40066_c3_g1_i3 Q7TN88 PK1L2_MOUSE 6.00E-08 GO:0005262; GO:0005509; GO:0030246; GO:0050982; GO:0016021; GO:0016020; GO:0007218 calcium channel activity; calcium ion binding; carbohydrate binding; detection of mechanical stimulus; integral to membrane; membrane; neuropeptide signaling pathway IPR001304; IPR016186; IPR016187; IPR000203; IPR000922; IPR008976; IPR022409; IPR002859; IPR013122; IPR003915; IPR000601; IPR001024; IPR014010; Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) Pkd1l2 Mus musculus (Mouse) TR40066_c3_g1_i5 P23132 LITH_BOVIN 2.00E-07 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Lithostathine (Islet cells regeneration factor) (ICRF) (Islet of Langerhans regenerating protein) (REG) (Pancreatic stone protein) (PSP) (Pancreatic thread protein) (PTP) [Cleaved into: Lithostathine A chain; Lithostathine B chain] PTP Bos taurus (Bovine) TR40066_c3_g1_i7 P48304 REG1B_HUMAN 1.00E-10 GO:0030246; GO:0008283; GO:0005576 carbohydrate binding; cell proliferation; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Lithostathine-1-beta (Pancreatic stone protein 2) (PSP-2) (Regenerating islet-derived protein 1-beta) (REG-1-beta) (Regenerating protein I beta) REG1B PSPS2 REGL Homo sapiens (Human) TR40067_c5_g3_i1 A9UM79 DRS7C_XENTR 3.00E-14 GO:0005576; GO:0016491 extracellular region; oxidoreductase activity IPR002198; IPR002347; IPR016040; Dehydrogenase/reductase SDR family member 7C (EC 1.1.-.-) dhrs7c Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40067_c5_g3_i4 A4IGM4 DHI1L_XENTR 4.00E-75 GO:0005576; GO:0016491 extracellular region; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Hydroxysteroid 11-beta-dehydrogenase 1-like protein (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type 3) (11-DH3) (11-beta-HSD3) hsd11b1l hsd3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40067_c5_g3_i5 A4IGM4 DHI1L_XENTR 6.00E-75 GO:0005576; GO:0016491 extracellular region; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Hydroxysteroid 11-beta-dehydrogenase 1-like protein (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type 3) (11-DH3) (11-beta-HSD3) hsd11b1l hsd3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR4007_c0_g1_i1 Q9WUB9 MARCO_MESAU 8.00E-11 GO:0005581; GO:0045087; GO:0016021; GO:0005044 collagen; innate immune response; integral to membrane; scavenger receptor activity IPR008160; IPR001190; IPR017448; Macrophage receptor MARCO (Macrophage receptor with collagenous structure) MARCO Mesocricetus auratus (Golden hamster) TR40072_c1_g2_i3 Q642G4 PEX14_RAT 1.00E-50 GO:0016021; GO:0034453; GO:0032091; GO:1901094; GO:0043433; GO:0005778; GO:0007031; GO:0036250; GO:0043234; GO:0051260; GO:0016560; GO:0044721; GO:0016561 "integral to membrane; microtubule anchoring; negative regulation of protein binding; negative regulation of protein homotetramerization; negative regulation of sequence-specific DNA binding transcription factor activity; peroxisomal membrane; peroxisome organization; peroxisome transport along microtubule; protein complex; protein homooligomerization; protein import into peroxisome matrix, docking; protein import into peroxisome matrix, substrate release; protein import into peroxisome matrix, translocation" IPR025655; IPR006785; Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) Pex14 Rattus norvegicus (Rat) TR40073_c2_g1_i1 Q75JP5 Y2471_DICDI 8.00E-11 IPR001715; Calponin homology domain-containing protein DDB_G0272472 DDB_G0272472 Dictyostelium discoideum (Slime mold) TR40073_c4_g1_i1 Q9QXZ0 MACF1_MOUSE 2.00E-06 GO:0016887; GO:0005794; GO:0043001; GO:0016055; GO:0003779; GO:0015629; GO:0005509; GO:0007050; GO:0006928; GO:0007163; GO:0001707; GO:0005874; GO:0008017; GO:0030177; GO:0006620; GO:0010632; GO:0051893; GO:0032886; GO:0032587; GO:0042060 ATPase activity; Golgi apparatus; Golgi to plasma membrane protein transport; Wnt receptor signaling pathway; actin binding; actin cytoskeleton; calcium ion binding; cell cycle arrest; cellular component movement; establishment or maintenance of cell polarity; mesoderm formation; microtubule; microtubule binding; positive regulation of Wnt receptor signaling pathway; posttranslational protein targeting to membrane; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of microtubule-based process; ruffle membrane; wound healing IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; IPR003108; IPR001101; IPR018159; IPR002017; Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7) Macf1 Acf7 Aclp7 Macf Mus musculus (Mouse) TR40073_c6_g1_i1 P21333 FLNA_HUMAN 2.00E-21 GO:0034988; GO:0031523; GO:0048365; GO:0017160; GO:0051764; GO:0015629; GO:0031532; GO:0051015; GO:0007195; GO:0005938; GO:0034329; GO:0042384; GO:0051220; GO:0005829; GO:0045022; GO:0001837; GO:0045184; GO:0070062; GO:0001948; GO:0042177; GO:0043433; GO:0005634; GO:0005886; GO:0030168; GO:0002576; GO:0043123; GO:0042993; GO:0042803; GO:0034394; GO:0050821; GO:0043113; GO:0004871; GO:0090307; GO:0005802 Q9WMX2; Q8N264; O95067; P46108; O75369; Q12948; P62993; P05556; P07228; P26010; O14786; P35372; Q86SQ0 Fc-gamma receptor I complex binding; Myb complex; Rac GTPase binding; Ral GTPase binding; actin crosslink formation; actin cytoskeleton; actin cytoskeleton reorganization; actin filament binding; adenylate cyclase-inhibiting dopamine receptor signaling pathway; cell cortex; cell junction assembly; cilium assembly; cytoplasmic sequestering of protein; cytosol; early endosome to late endosome transport; epithelial to mesenchymal transition; establishment of protein localization; extracellular vesicular exosome; glycoprotein binding; negative regulation of protein catabolic process; negative regulation of sequence-specific DNA binding transcription factor activity; nucleus; plasma membrane; platelet activation; platelet degranulation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor import into nucleus; protein homodimerization activity; protein localization to cell surface; protein stabilization; receptor clustering; signal transducer activity; spindle assembly involved in mitosis; trans-Golgi network IPR001589; IPR001715; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) FLNA FLN FLN1 Homo sapiens (Human) TR40073_c7_g3_i1 P21333 FLNA_HUMAN 4.00E-27 GO:0034988; GO:0031523; GO:0048365; GO:0017160; GO:0051764; GO:0015629; GO:0031532; GO:0051015; GO:0007195; GO:0005938; GO:0034329; GO:0042384; GO:0051220; GO:0005829; GO:0045022; GO:0001837; GO:0045184; GO:0070062; GO:0001948; GO:0042177; GO:0043433; GO:0005634; GO:0005886; GO:0030168; GO:0002576; GO:0043123; GO:0042993; GO:0042803; GO:0034394; GO:0050821; GO:0043113; GO:0004871; GO:0090307; GO:0005802 Q9WMX2; Q8N264; O95067; P46108; O75369; Q12948; P62993; P05556; P07228; P26010; O14786; P35372; Q86SQ0 Fc-gamma receptor I complex binding; Myb complex; Rac GTPase binding; Ral GTPase binding; actin crosslink formation; actin cytoskeleton; actin cytoskeleton reorganization; actin filament binding; adenylate cyclase-inhibiting dopamine receptor signaling pathway; cell cortex; cell junction assembly; cilium assembly; cytoplasmic sequestering of protein; cytosol; early endosome to late endosome transport; epithelial to mesenchymal transition; establishment of protein localization; extracellular vesicular exosome; glycoprotein binding; negative regulation of protein catabolic process; negative regulation of sequence-specific DNA binding transcription factor activity; nucleus; plasma membrane; platelet activation; platelet degranulation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor import into nucleus; protein homodimerization activity; protein localization to cell surface; protein stabilization; receptor clustering; signal transducer activity; spindle assembly involved in mitosis; trans-Golgi network IPR001589; IPR001715; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) FLNA FLN FLN1 Homo sapiens (Human) TR40073_c8_g1_i1 F7H9X2 TRIM2_CALJA 1.00E-07 GO:0005737; GO:0043523; GO:0004842; GO:0008270 cytoplasm; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Callithrix jacchus (White-tufted-ear marmoset) TR40073_c8_g1_i2 Q9MZD2 FLNB_RABIT 1.00E-12 GO:0005938; GO:0005856 cell cortex; cytoskeleton IPR001298; IPR017868; IPR013783; IPR014756; Filamin-B (FLN-B) (ABP-280-like protein) (Actin-binding-like protein) (Beta-filamin) (C254) (Fragment) FLNB Oryctolagus cuniculus (Rabbit) TR40073_c9_g1_i1 Q550R2 CTXB_DICDI 7.00E-08 GO:0051015; GO:0005938; GO:0031252; GO:0000902; GO:0032154; GO:0030866; GO:0005856; GO:0045184; GO:0000281; GO:0045335; GO:0010628; GO:0001934; GO:0032317; GO:0043520; GO:0030587 Q54HG2 actin filament binding; cell cortex; cell leading edge; cell morphogenesis; cleavage furrow; cortical actin cytoskeleton organization; cytoskeleton; establishment of protein localization; mitotic cytokinesis; phagocytic vesicle; positive regulation of gene expression; positive regulation of protein phosphorylation; regulation of Rap GTPase activity; regulation of myosin II filament assembly; sorocarp development IPR001589; IPR001715; IPR015383; Cortexillin-2 (Cortexillin II) ctxB DDB_G0276893 Dictyostelium discoideum (Slime mold) TR40074_c1_g2_i3 Q2KII1 ATF3_BOVIN 4.00E-06 GO:0006094; GO:0045892; GO:0005634; GO:0006950; GO:0043565; GO:0003700; GO:0035914; GO:0006351 "gluconeogenesis; negative regulation of transcription, DNA-dependent; nucleus; response to stress; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; skeletal muscle cell differentiation; transcription, DNA-dependent" IPR004827; IPR000837; Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3) ATF3 Bos taurus (Bovine) TR40076_c0_g1_i1 P70425 RIT2_MOUSE 2.00E-15 GO:0005525; GO:0003924; GO:0005634; GO:0005886; GO:0007264 Q13129 GTP binding; GTPase activity; nucleus; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; GTP-binding protein Rit2 (Ras-like protein expressed in neurons) (Ras-like without CAAX protein 2) Rit2 Rin Roc2 Mus musculus (Mouse) TR40076_c0_g1_i2 Q5RAV6 RAB6A_PONAB 2.00E-10 GO:0005525; GO:0003924; GO:0005794; GO:0000139; GO:0000042; GO:0007264 GTP binding; GTPase activity; Golgi apparatus; Golgi membrane; protein targeting to Golgi; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-6A RAB6A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40076_c1_g1_i1 E1BD59 TRI56_BOVIN 6.00E-18 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) TR40077_c0_g5_i2 Q86VM9 ZCH18_HUMAN 3.00E-28 GO:0046872; GO:0005634 metal ion binding; nucleus IPR000571; Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) ZC3H18 NHN1 Homo sapiens (Human) TR40077_c0_g5_i3 Q0P678 ZCH18_MOUSE 3.00E-06 GO:0046872; GO:0005634 metal ion binding; nucleus IPR000571; Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) Zc3h18 Nhn1 Mus musculus (Mouse) TR40078_c1_g2_i2 P54802 ANAG_HUMAN 1.00E-136 GO:0004561; GO:0005975; GO:0021680; GO:0006027; GO:0060119; GO:0045475; GO:0043202; GO:0007040; GO:0042474; GO:0007399; GO:0046548; GO:0044281 alpha-N-acetylglucosaminidase activity; carbohydrate metabolic process; cerebellar Purkinje cell layer development; glycosaminoglycan catabolic process; inner ear receptor cell development; locomotor rhythm; lysosomal lumen; lysosome organization; middle ear morphogenesis; nervous system development; retinal rod cell development; small molecule metabolic process IPR017853; IPR007781; IPR024732; IPR024240; IPR024733; Alpha-N-acetylglucosaminidase (EC 3.2.1.50) (N-acetyl-alpha-glucosaminidase) (NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form] NAGLU UFHSD1 Homo sapiens (Human) TR40078_c1_g4_i6 P54802 ANAG_HUMAN 6.00E-10 GO:0004561; GO:0005975; GO:0021680; GO:0006027; GO:0060119; GO:0045475; GO:0043202; GO:0007040; GO:0042474; GO:0007399; GO:0046548; GO:0044281 alpha-N-acetylglucosaminidase activity; carbohydrate metabolic process; cerebellar Purkinje cell layer development; glycosaminoglycan catabolic process; inner ear receptor cell development; locomotor rhythm; lysosomal lumen; lysosome organization; middle ear morphogenesis; nervous system development; retinal rod cell development; small molecule metabolic process IPR017853; IPR007781; IPR024732; IPR024240; IPR024733; Alpha-N-acetylglucosaminidase (EC 3.2.1.50) (N-acetyl-alpha-glucosaminidase) (NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form] NAGLU UFHSD1 Homo sapiens (Human) TR40080_c5_g2_i1 Q8N695 SC5A8_HUMAN 9.00E-15 GO:0016324; GO:0006915; GO:0016021; GO:0006811; GO:0005886; GO:0006814; GO:0015293; GO:0055085 apical plasma membrane; apoptotic process; integral to membrane; ion transport; plasma membrane; sodium ion transport; symporter activity; transmembrane transport IPR001734; IPR019900; Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8) SLC5A8 AIT SMCT SMCT1 Homo sapiens (Human) TR40081_c3_g1_i4 A8QZJ5 MCTX1_MILDI 1.00E-22 GO:0005576; GO:0042151 extracellular region; nematocyst IPR026645; Millepora cytotoxin-1 (MCTx-1) Millepora dichotoma (Net fire coral) TR40081_c3_g1_i5 P83553 DERM_BIOGL 8.00E-23 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR026645; Dermatopontin (Tyrosine-rich acidic matrix protein) (TRAMP) Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail) TR40081_c4_g1_i1 Q8C767 PPR3B_MOUSE 7.00E-36 GO:0042587; GO:0005977; GO:0043231; GO:0019888; GO:0000164; GO:0005979; GO:0005981 glycogen granule; glycogen metabolic process; intracellular membrane-bounded organelle; protein phosphatase regulator activity; protein phosphatase type 1 complex; regulation of glycogen biosynthetic process; regulation of glycogen catabolic process IPR005036; IPR017434; Protein phosphatase 1 regulatory subunit 3B (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL) (PTG) Ppp1r3b Ppp1r4 Mus musculus (Mouse) TR40081_c4_g1_i2 Q8C767 PPR3B_MOUSE 6.00E-36 GO:0042587; GO:0005977; GO:0043231; GO:0019888; GO:0000164; GO:0005979; GO:0005981 glycogen granule; glycogen metabolic process; intracellular membrane-bounded organelle; protein phosphatase regulator activity; protein phosphatase type 1 complex; regulation of glycogen biosynthetic process; regulation of glycogen catabolic process IPR005036; IPR017434; Protein phosphatase 1 regulatory subunit 3B (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL) (PTG) Ppp1r3b Ppp1r4 Mus musculus (Mouse) TR40082_c2_g3_i1 Q8CIF4 BTD_MOUSE 2.00E-27 GO:0045177; GO:0006768; GO:0047708; GO:0005615; GO:0005730; GO:0043204 apical part of cell; biotin metabolic process; biotinidase activity; extracellular space; nucleolus; perikaryon IPR012101; IPR003010; Biotinidase (Biotinase) (EC 3.5.1.12) Btd Mus musculus (Mouse) TR40082_c2_g5_i1 Q9Z0K8 VNN1_MOUSE 4.00E-104 GO:0034235; GO:0002526; GO:0031225; GO:0016337; GO:0002544; GO:0045087; GO:0016021; GO:1902176; GO:0017159; GO:0015939; GO:0005886; GO:0033089 GPI anchor binding; acute inflammatory response; anchored to membrane; cell-cell adhesion; chronic inflammatory response; innate immune response; integral to membrane; negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress; pantetheine hydrolase activity; pantothenate metabolic process; plasma membrane; positive regulation of T cell differentiation in thymus IPR012101; IPR003010; Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Vascular non-inflammatory molecule 1) (Vanin-1) Vnn1 Mus musculus (Mouse) TR40082_c2_g5_i2 O95497 VNN1_HUMAN 3.00E-102 GO:0034235; GO:0002526; GO:0031225; GO:0016337; GO:0006928; GO:0002544; GO:0045087; GO:0016021; GO:0043066; GO:1902176; GO:0017159; GO:0015939; GO:0005886; GO:0033089; GO:0006979 GPI anchor binding; acute inflammatory response; anchored to membrane; cell-cell adhesion; cellular component movement; chronic inflammatory response; innate immune response; integral to membrane; negative regulation of apoptotic process; negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress; pantetheine hydrolase activity; pantothenate metabolic process; plasma membrane; positive regulation of T cell differentiation in thymus; response to oxidative stress IPR012101; IPR003010; Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Tiff66) (Vascular non-inflammatory molecule 1) (Vanin-1) VNN1 Homo sapiens (Human) TR40084_c1_g1_i1 P16522 CDC23_YEAST 6.00E-48 GO:0005680; GO:0031145; GO:0051301; GO:0000777; GO:0007067; GO:0016567; GO:0030071 P40577; Q12379 anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; condensed chromosome kinetochore; mitosis; protein ubiquitination; regulation of mitotic metaphase/anaphase transition IPR007192; IPR013026; IPR011990; IPR001440; IPR019734; Protein modification; protein ubiquitination. Anaphase-promoting complex subunit CDC23 (Cell division control protein 23) CDC23 YHR166C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40084_c1_g4_i1 Q9STS3 CDC23_ARATH 4.00E-87 GO:0005680; GO:0051301; GO:0007067; GO:0016567; GO:0031347; GO:0030071 Q8H1U5 anaphase-promoting complex; cell division; mitosis; protein ubiquitination; regulation of defense response; regulation of mitotic metaphase/anaphase transition IPR007192; IPR013026; IPR011990; IPR001440; IPR019734; Protein modification; protein ubiquitination. Anaphase-promoting complex subunit 8 (Cell division cycle protein 23 homolog) (CDC23 homolog) (Cyclosome subunit 8) APC8 CDC23 At3g48150 T24C20.30 Arabidopsis thaliana (Mouse-ear cress) TR40084_c1_g4_i2 A1A4R8 CDC23_BOVIN 3.00E-146 GO:0005680; GO:0051301; GO:0007080; GO:0070979; GO:0030071 anaphase-promoting complex; cell division; mitotic metaphase plate congression; protein K11-linked ubiquitination; regulation of mitotic metaphase/anaphase transition IPR007192; IPR013026; IPR011990; IPR001440; IPR019734; Protein modification; protein ubiquitination. Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8) CDC23 ANAPC8 Bos taurus (Bovine) TR40084_c1_g4_i3 Q9UJX2 CDC23_HUMAN 9.00E-145 GO:0005680; GO:0031145; GO:0051301; GO:0005829; GO:0007091; GO:0000080; GO:0007080; GO:0007094; GO:0051436; GO:0005654; GO:0051437; GO:0070979; GO:0007096; GO:0004842 anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; cytosol; metaphase/anaphase transition of mitotic cell cycle; mitotic G1 phase; mitotic metaphase plate congression; mitotic spindle assembly checkpoint; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; protein K11-linked ubiquitination; regulation of exit from mitosis; ubiquitin-protein ligase activity IPR007192; IPR013026; IPR011990; IPR001440; IPR019734; Protein modification; protein ubiquitination. Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8) CDC23 ANAPC8 Homo sapiens (Human) TR40085_c1_g1_i1 Q55BR6 ORC3_DICDI 4.00E-12 GO:0003677; GO:0006260; GO:0005664 DNA binding; DNA replication; nuclear origin of replication recognition complex IPR020795; IPR014710; Origin recognition complex subunit 3 (Origin replication complex subunit C) orcC orc3 DDB_G0271078 Dictyostelium discoideum (Slime mold) TR40085_c1_g1_i2 Q32PJ3 ORC3_BOVIN 1.00E-178 GO:0003677; GO:0006260; GO:0005664 DNA binding; DNA replication; nuclear origin of replication recognition complex IPR020795; Origin recognition complex subunit 3 ORC3 ORC3L Bos taurus (Bovine) TR40090_c0_g1_i1 Q80VI1 TRI56_MOUSE 3.00E-13 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) TR40090_c0_g1_i2 A4IF63 TRIM2_BOVIN 4.00E-69 GO:0005737; GO:0043523; GO:0004842; GO:0008270 cytoplasm; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) TR40090_c0_g1_i3 A4IF63 TRIM2_BOVIN 6.00E-42 GO:0005737; GO:0043523; GO:0004842; GO:0008270 cytoplasm; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) TR40090_c0_g1_i4 Q9BRZ2 TRI56_HUMAN 9.00E-13 GO:0005829; GO:0051607; GO:0032608; GO:0032481; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytosol; defense response to virus; interferon-beta production; positive regulation of type I interferon production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) TR40090_c0_g1_i5 Q80VI1 TRI56_MOUSE 5.00E-14 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) TR40090_c0_g1_i6 Q9H8W5 TRI45_HUMAN 2.00E-16 GO:0060348; GO:0005737; GO:0005634; GO:0008270 bone development; cytoplasm; nucleus; zinc ion binding IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) TR40091_c1_g1_i1 Q5FVR4 ERI1_RAT 8.00E-99 GO:0008408; GO:0005737; GO:0031047; GO:0071204; GO:0071207; GO:0046872; GO:0005730; GO:0031125; GO:0019843; GO:0043022 3'-5' exonuclease activity; cytoplasm; gene silencing by RNA; histone pre-mRNA 3'end processing complex; histone pre-mRNA stem-loop binding; metal ion binding; nucleolus; rRNA 3'-end processing; rRNA binding; ribosome binding IPR006055; IPR013520; IPR012337; IPR003034; 3'-5' exoribonuclease 1 (EC 3.1.-.-) (Histone mRNA 3'-exonuclease 1) Eri1 Thex1 Rattus norvegicus (Rat) TR40091_c1_g1_i3 O44406 ERI1_CAEEL 2.00E-51 GO:0000175; GO:0003723; GO:0006401; GO:0016246; GO:0005737; GO:0000467; GO:0007281; GO:0045132; GO:0003676 P34529 "3'-5'-exoribonuclease activity; RNA binding; RNA catabolic process; RNA interference; cytoplasm; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); germ cell development; meiotic chromosome segregation; nucleic acid binding" IPR006055; IPR013520; IPR012337; IPR003034; 3'-5' exonuclease eri-1 (EC 3.1.-.-) (Enhanced RNAi protein) eri-1 T07A9.5 Caenorhabditis elegans TR40092_c1_g2_i3 Q54LV7 JMJCC_DICDI 5.00E-10 IPR003347; JmjC domain-containing protein C (Jumonji domain-containing protein C) jcdC DDB_G0286391 Dictyostelium discoideum (Slime mold) TR40092_c1_g2_i4 P0C872 JMJD7_MOUSE 4.00E-105 IPR003347; JmjC domain-containing protein 7 (Jumonji domain-containing protein 7) Jmjd7 Mus musculus (Mouse) TR40094_c0_g2_i2 O57321 EAA1_AMBTI 9.00E-67 GO:0016021; GO:0017153 integral to membrane; sodium:dicarboxylate symporter activity IPR001991; IPR018107; Excitatory amino acid transporter 1 (SEAAT1) SLC1A3 EAAT1 Ambystoma tigrinum (Eastern tiger salamander) TR40095_c2_g1_i1 P56213 ALR_MOUSE 2.00E-60 GO:0050660; GO:0005758; GO:0005739; GO:0015035; GO:0016972 flavin adenine dinucleotide binding; mitochondrial intermembrane space; mitochondrion; protein disulfide oxidoreductase activity; thiol oxidase activity IPR017905; FAD-linked sulfhydryl oxidase ALR (EC 1.8.3.2) (Augmenter of liver regeneration) Gfer Alr MNCb-0663 Mus musculus (Mouse) TR40095_c3_g4_i1 Q9R087 GPC6_MOUSE 8.00E-118 GO:0005796; GO:0031225; GO:0016477; GO:0005615; GO:0005887; GO:0005578 Golgi lumen; anchored to membrane; cell migration; extracellular space; integral to plasma membrane; proteinaceous extracellular matrix IPR001863; IPR019803; Glypican-6 [Cleaved into: Secreted glypican-6] Gpc6 Mus musculus (Mouse) TR40095_c3_g4_i4 Q9R087 GPC6_MOUSE 8.00E-118 GO:0005796; GO:0031225; GO:0016477; GO:0005615; GO:0005887; GO:0005578 Golgi lumen; anchored to membrane; cell migration; extracellular space; integral to plasma membrane; proteinaceous extracellular matrix IPR001863; IPR019803; Glypican-6 [Cleaved into: Secreted glypican-6] Gpc6 Mus musculus (Mouse) TR40096_c0_g1_i1 Q3MHH4 SYQ_BOVIN 0 GO:0005524; GO:0005737; GO:0004819; GO:0006425 ATP binding; cytoplasm; glutamine-tRNA ligase activity; glutaminyl-tRNA aminoacylation IPR001412; IPR004514; IPR007638; IPR007639; IPR000924; IPR020061; IPR020058; IPR020059; IPR020056; IPR011035; IPR014729; Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS) QARS Bos taurus (Bovine) TR40097_c0_g1_i1 P45867 ACDA_BACSU 4.00E-83 GO:0003995; GO:0006635; GO:0050660 acyl-CoA dehydrogenase activity; fatty acid beta-oxidation; flavin adenine dinucleotide binding IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Lipid metabolism; fatty acid beta-oxidation. Acyl-CoA dehydrogenase (EC 1.3.99.-) acdA acd BSU37170 Bacillus subtilis (strain 168) TR40097_c0_g1_i2 P15651 ACADS_RAT 6.00E-154 GO:0003995; GO:0046359; GO:0004085; GO:0033539; GO:0000062; GO:0050660; GO:0005759; GO:0031966; GO:0051289; GO:0051384; GO:0042594 acyl-CoA dehydrogenase activity; butyrate catabolic process; butyryl-CoA dehydrogenase activity; fatty acid beta-oxidation using acyl-CoA dehydrogenase; fatty-acyl-CoA binding; flavin adenine dinucleotide binding; mitochondrial matrix; mitochondrial membrane; protein homotetramerization; response to glucocorticoid stimulus; response to starvation IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Lipid metabolism; mitochondrial fatty acid beta-oxidation. "Short-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD) (EC 1.3.8.1) (Butyryl-CoA dehydrogenase)" Acads Rattus norvegicus (Rat) TR40098_c2_g2_i1 Q460N5 PAR14_HUMAN 2.00E-21 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR40098_c2_g2_i2 Q8BZ20 PAR12_MOUSE 3.00E-15 GO:0003950; GO:0046872; GO:0005634 NAD+ ADP-ribosyltransferase activity; metal ion binding; nucleus IPR012317; IPR004170; IPR000571; Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) Parp12 Zc3hdc1 Mus musculus (Mouse) TR40098_c2_g2_i3 Q8ZXT3 Y1111_PYRAE 9.00E-14 IPR002589; Uncharacterized protein PAE1111 PAE1111 Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827) TR40098_c2_g2_i4 Q8BZ20 PAR12_MOUSE 4.00E-14 GO:0003950; GO:0046872; GO:0005634 NAD+ ADP-ribosyltransferase activity; metal ion binding; nucleus IPR012317; IPR004170; IPR000571; Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) Parp12 Zc3hdc1 Mus musculus (Mouse) TR40098_c2_g2_i5 Q460N3 PAR15_HUMAN 8.00E-14 GO:0003950; GO:0005634; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) TR40098_c2_g3_i1 Q97UU4 Y2899_SULSO 6.00E-10 IPR002589; Uncharacterized protein SSO2899 SSO2899 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) TR40100_c8_g5_i1 Q9TU25 RAC2_BOVIN 9.00E-84 GO:0005525; GO:0003924; GO:0030036; GO:0030031; GO:0006935; GO:0005737; GO:0016020; GO:0005635; GO:0008284; GO:0060263; GO:0007264 GTP binding; GTPase activity; actin cytoskeleton organization; cell projection assembly; chemotaxis; cytoplasm; membrane; nuclear envelope; positive regulation of cell proliferation; regulation of respiratory burst; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Ras-related C3 botulinum toxin substrate 2 (p21-Rac2) RAC2 Bos taurus (Bovine) TR40100_c8_g5_i5 O96390 RACF1_DICDI 8.00E-63 GO:0005525; GO:0005622; GO:0016020; GO:0019953; GO:0007264 GTP binding; intracellular; membrane; sexual reproduction; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Rho-related protein racF1 racF1 DDB_G0269176 Dictyostelium discoideum (Slime mold) TR40100_c8_g6_i1 O76321 RECG_ENTHI 2.00E-71 GO:0005525; GO:0005737; GO:0005856; GO:0005886; GO:0007264 GTP binding; cytoplasm; cytoskeleton; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Rho-related protein racG RACG Entamoeba histolytica TR40100_c8_g6_i2 Q9HF54 RHO1_ASHGO 3.00E-57 GO:0005525; GO:0005622; GO:0005886; GO:0007264 GTP binding; intracellular; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; GTP-binding protein RHO1 RHO1 ABR183W Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR40100_c8_g6_i3 C4YDI6 CDC42_CANAW 2.00E-70 GO:0005525; GO:0007049; GO:0051301; GO:0005622; GO:0009405; GO:0005886; GO:0007264 GTP binding; cell cycle; cell division; intracellular; pathogenesis; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Cell division control protein 42 homolog CDC42 CAWG_00581 Candida albicans (strain WO-1) (Yeast) TR40101_c3_g3_i10 Q56R14 TRI33_XENLA 3.00E-07 GO:0003677; GO:0016874; GO:0005634; GO:0016567; GO:0006355; GO:0006351; GO:0008270 "DNA binding; ligase activity; nucleus; protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 ecto Xenopus laevis (African clawed frog) TR40101_c3_g3_i2 Q924W6 TRI66_MOUSE 7.00E-07 GO:0010369; GO:0045892; GO:0005634; GO:0008270 "chromocenter; negative regulation of transcription, DNA-dependent; nucleus; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR013083; Tripartite motif-containing protein 66 (Transcriptional intermediary factor 1 delta) Trim66 Tif1d Mus musculus (Mouse) TR40101_c3_g3_i5 Q6E2N3 TRI33_DANRE 1.00E-10 GO:0003677; GO:0016874; GO:0005634; GO:0016567; GO:0006355; GO:0006351; GO:0008270 "DNA binding; ligase activity; nucleus; protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (Protein moonshine) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 mon Danio rerio (Zebrafish) (Brachydanio rerio) TR40101_c3_g3_i7 Q56R14 TRI33_XENLA 3.00E-07 GO:0003677; GO:0016874; GO:0005634; GO:0016567; GO:0006355; GO:0006351; GO:0008270 "DNA binding; ligase activity; nucleus; protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 ecto Xenopus laevis (African clawed frog) TR40104_c2_g1_i1 O75165 DJC13_HUMAN 0 GO:0005765 lysosomal membrane IPR011989; IPR016024; IPR001623; IPR025640; IPR003169; DnaJ homolog subfamily C member 13 (Required for receptor-mediated endocytosis 8) (RME-8) DNAJC13 KIAA0678 RME8 Homo sapiens (Human) TR40105_c1_g3_i2 P52555 ERP29_RAT 2.00E-42 GO:0005788; GO:0006886; GO:0042470; GO:0006457; GO:0009306; GO:0006950; GO:0005790; GO:0030133 endoplasmic reticulum lumen; intracellular protein transport; melanosome; protein folding; protein secretion; response to stress; smooth endoplasmic reticulum; transport vesicle IPR016855; IPR011679; IPR012883; IPR012336; Endoplasmic reticulum resident protein 29 (ERp29) (Endoplasmic reticulum resident protein 31) (ERp31) Erp29 Rattus norvegicus (Rat) TR40105_c1_g3_i4 P57759 ERP29_MOUSE 5.00E-44 GO:0009986; GO:0005783; GO:0005788; GO:0042470; GO:0009306 cell surface; endoplasmic reticulum; endoplasmic reticulum lumen; melanosome; protein secretion IPR016855; IPR011679; IPR012883; IPR012336; Endoplasmic reticulum resident protein 29 (ERp29) Erp29 Mus musculus (Mouse) TR40108_c0_g2_i1 Q6P3S6 FBX42_HUMAN 4.00E-108 IPR001810; IPR015915; IPR011498; F-box only protein 42 (Just one F-box and Kelch domain-containing protein) FBXO42 FBX42 JFK KIAA1332 Homo sapiens (Human) TR40109_c2_g1_i1 P38237 UBP14_YEAST 3.00E-09 GO:0005737; GO:0045721; GO:0005634; GO:0008242; GO:0043161; GO:0004221; GO:0004843; GO:0008270 cytoplasm; negative regulation of gluconeogenesis; nucleus; omega peptidase activity; proteasomal ubiquitin-dependent protein catabolic process; ubiquitin thiolesterase activity; ubiquitin-specific protease activity; zinc ion binding IPR018200; IPR001394; IPR009060; IPR015940; IPR000449; IPR016652; IPR013083; IPR001607; Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Glucose-induced degradation protein 6) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) UBP14 GID6 YBR058C YBR0515 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40109_c2_g1_i2 Q6NXA9 UBXN1_DANRE 3.00E-45 GO:0071796; GO:0005737; GO:0032435; GO:0031397 K6-linked polyubiquitin binding; cytoplasm; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein ubiquitination IPR009060; IPR015940; IPR000449; IPR001012; UBX domain-containing protein 1 (SAPK substrate protein 1) ubxn1 saks1 zgc:77531 Danio rerio (Zebrafish) (Brachydanio rerio) TR40109_c4_g1_i1 Q6NWY9 PR40B_HUMAN 7.00E-138 GO:0008380; GO:0006397; GO:0016607 RNA splicing; mRNA processing; nuclear speck IPR002713; IPR001202; Pre-mRNA-processing factor 40 homolog B (Huntingtin yeast partner C) (Huntingtin-interacting protein C) PRPF40B HYPC Homo sapiens (Human) TR40109_c4_g4_i1 Q61048 WBP4_MOUSE 6.00E-09 GO:0045292; GO:0016607; GO:0003676; GO:0005886; GO:0005681; GO:0008270 "mRNA cis splicing, via spliceosome; nuclear speck; nucleic acid binding; plasma membrane; spliceosomal complex; zinc ion binding" IPR001202; IPR000690; IPR003604; IPR013085; WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4) Wbp4 Fbp21 Fnbp21 Mus musculus (Mouse) TR4011_c0_g1_i1 Q86UD0 SAPC2_HUMAN 2.00E-10 GO:0005737; GO:0005730 cytoplasm; nucleolus IPR026831; IPR026828; Suppressor APC domain-containing protein 2 (Tumor specificity and mitosis phase-dependent expression protein) (TS/MDEP) (p42.3) SAPCD2 C9orf140 Homo sapiens (Human) TR40110_c4_g1_i1 P41437 IAP3_NPVOP 3.00E-15 GO:0006915; GO:0016874; GO:0039648; GO:0008270 apoptotic process; ligase activity; modulation by virus of host protein ubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; E3 ubiquitin-protein ligase IAP-3 (EC 6.3.2.-) (IAP-3) IAP3 IAP ORF35 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) TR40110_c4_g1_i2 Q6R7I2 IAP1_OSHVF 6.00E-12 GO:0008270 zinc ion binding IPR001370; IPR001841; IPR013083; Putative apoptosis inhibitor ORF42 ORF42 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) TR40110_c4_g1_i3 P41437 IAP3_NPVOP 9.00E-18 GO:0006915; GO:0016874; GO:0039648; GO:0008270 apoptotic process; ligase activity; modulation by virus of host protein ubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; E3 ubiquitin-protein ligase IAP-3 (EC 6.3.2.-) (IAP-3) IAP3 IAP ORF35 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) TR40110_c4_g1_i4 P41436 IAP_GVCPM 9.00E-13 GO:0006915; GO:0008270 apoptotic process; zinc ion binding IPR001370; IPR001841; Apoptosis inhibitor IAP IAP Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) TR40110_c4_g1_i5 Q96CA5 BIRC7_HUMAN 1.00E-10 GO:0005794; GO:0007257; GO:0006309; GO:0004869; GO:0019899; GO:0043066; GO:0005634; GO:0042127; GO:0070247; GO:0004842; GO:0008270 P55211; Q9NR28; O43464 Golgi apparatus; activation of JUN kinase activity; apoptotic DNA fragmentation; cysteine-type endopeptidase inhibitor activity; enzyme binding; negative regulation of apoptotic process; nucleus; regulation of cell proliferation; regulation of natural killer cell apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; IPR017907; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)] BIRC7 KIAP LIVIN MLIAP RNF50 UNQ5800/PRO19607/PRO21344 Homo sapiens (Human) TR40111_c1_g1_i1 Q91W90 TXND5_MOUSE 9.00E-69 GO:0045454; GO:0005788; GO:0006662; GO:0016853; GO:0015035 cell redox homeostasis; endoplasmic reticulum lumen; glycerol ether metabolic process; isomerase activity; protein disulfide oxidoreductase activity IPR005788; IPR005746; IPR012336; IPR017937; IPR013766; Thioredoxin domain-containing protein 5 (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Plasma cell-specific thioredoxin-related protein) (PC-TRP) (Thioredoxin-like protein p46) Txndc5 Tlp46 Mus musculus (Mouse) TR40111_c4_g2_i1 Q8GYD1 PDI51_ARATH 4.00E-15 GO:0045454 cell redox homeostasis IPR012336; IPR013766; Protein disulfide-isomerase 5-1 (AtPDIL5-1) (Protein disulfide-isomerase 6-1) (AtPDIL6-1) PDIL5-1 PDIL6-1 At1g07960 T6D22.5 Arabidopsis thaliana (Mouse-ear cress) TR40111_c4_g3_i1 Q8NBS9 TXND5_HUMAN 2.00E-32 GO:0045454; GO:0005783; GO:0005788; GO:0006662; GO:0016853; GO:0043202; GO:0043066; GO:0006892; GO:0015035 Q13162 cell redox homeostasis; endoplasmic reticulum; endoplasmic reticulum lumen; glycerol ether metabolic process; isomerase activity; lysosomal lumen; negative regulation of apoptotic process; post-Golgi vesicle-mediated transport; protein disulfide oxidoreductase activity IPR005788; IPR005746; IPR012336; IPR017937; IPR013766; Thioredoxin domain-containing protein 5 (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46) TXNDC5 TLP46 UNQ364/PRO700 Homo sapiens (Human) TR40111_c5_g1_i1 Q5I0H9 PDIA5_RAT 2.00E-128 GO:0045454; GO:0005788; GO:0006662; GO:0003756; GO:0015035; GO:0006457; GO:0006950 cell redox homeostasis; endoplasmic reticulum lumen; glycerol ether metabolic process; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; protein folding; response to stress IPR005746; IPR012336; IPR017937; IPR013766; Protein disulfide-isomerase A5 (EC 5.3.4.1) Pdia5 Rattus norvegicus (Rat) TR40112_c1_g1_i1 P97363 SPTC2_MOUSE 6.00E-103 GO:0046513; GO:0016021; GO:0005739; GO:0030170; GO:0004758; GO:0017059; GO:0046511; GO:0006686; GO:0046512 ceramide biosynthetic process; integral to membrane; mitochondrion; pyridoxal phosphate binding; serine C-palmitoyltransferase activity; serine C-palmitoyltransferase complex; sphinganine biosynthetic process; sphingomyelin biosynthetic process; sphingosine biosynthetic process IPR001917; IPR004839; IPR015424; IPR015421; IPR015422; Lipid metabolism; sphingolipid metabolism. Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2) Sptlc2 Lcb2 Mus musculus (Mouse) TR40112_c2_g1_i1 Q5SHZ8 BIKB_THET8 5.00E-15 GO:0008710; GO:0009102; GO:0008890; GO:0030170 8-amino-7-oxononanoate synthase activity; biotin biosynthetic process; glycine C-acetyltransferase activity; pyridoxal phosphate binding IPR001917; IPR004839; IPR004723; IPR010962; IPR015424; IPR015421; IPR015422; Cofactor biosynthesis; biotin biosynthesis. 8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase (AONS/AKB ligase) (EC 2.3.1.29) (EC 2.3.1.47) (7-keto-8-amino-pelargonic acid synthase) (7-KAP synthase) (KAPA synthase) (8-amino-7-ketopelargonate synthase) (Alpha-oxoamine synthase) (Glycine acetyltransferase) TTHA1582 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) TR40112_c2_g1_i2 A4SPR6 BIOF_AERS4 7.00E-11 GO:0008710; GO:0009102; GO:0030170 8-amino-7-oxononanoate synthase activity; biotin biosynthetic process; pyridoxal phosphate binding IPR022834; IPR001917; IPR004839; IPR004723; IPR015424; IPR015421; IPR015422; Cofactor biosynthesis; biotin biosynthesis. 8-amino-7-oxononanoate synthase (AONS) (EC 2.3.1.47) (7-keto-8-amino-pelargonic acid synthase) (7-KAP synthase) (KAPA synthase) (8-amino-7-ketopelargonate synthase) bioF ASA_2876 Aeromonas salmonicida (strain A449) TR40112_c2_g2_i1 P97363 SPTC2_MOUSE 4.00E-135 GO:0046513; GO:0016021; GO:0005739; GO:0030170; GO:0004758; GO:0017059; GO:0046511; GO:0006686; GO:0046512 ceramide biosynthetic process; integral to membrane; mitochondrion; pyridoxal phosphate binding; serine C-palmitoyltransferase activity; serine C-palmitoyltransferase complex; sphinganine biosynthetic process; sphingomyelin biosynthetic process; sphingosine biosynthetic process IPR001917; IPR004839; IPR015424; IPR015421; IPR015422; Lipid metabolism; sphingolipid metabolism. Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2) Sptlc2 Lcb2 Mus musculus (Mouse) TR40112_c2_g2_i2 Q65ML1 BIOF_BACLD 3.00E-40 GO:0008710; GO:0009102; GO:0030170 8-amino-7-oxononanoate synthase activity; biotin biosynthetic process; pyridoxal phosphate binding IPR001917; IPR004839; IPR004723; IPR015424; IPR015421; IPR015422; Cofactor biosynthesis; biotin biosynthesis. Putative 8-amino-7-oxononanoate synthase (AONS) (EC 2.3.1.47) (7-keto-8-amino-pelargonic acid synthase) (7-KAP synthase) (8-amino-7-ketopelargonate synthase) bioF BLi00768 BL00954 Bacillus licheniformis (strain DSM 13 / ATCC 14580) TR40112_c2_g2_i3 Q8KZM9 BIOF_BACNA 4.00E-30 GO:0008710; GO:0009102; GO:0030170 8-amino-7-oxononanoate synthase activity; biotin biosynthetic process; pyridoxal phosphate binding IPR001917; IPR004839; IPR004723; IPR015424; IPR015421; IPR015422; Cofactor biosynthesis; biotin biosynthesis. Putative 8-amino-7-oxononanoate synthase (AONS) (EC 2.3.1.47) (7-keto-8-amino-pelargonic acid synthase) (7-KAP synthase) (8-amino-7-ketopelargonate synthase) bioF Bacillus subtilis subsp. natto TR40112_c2_g2_i4 O25320 BIKB_HELPY 6.00E-13 GO:0008710; GO:0009102; GO:0030170 8-amino-7-oxononanoate synthase activity; biotin biosynthetic process; pyridoxal phosphate binding IPR001917; IPR004839; IPR015424; IPR015421; Cofactor biosynthesis; biotin biosynthesis. 8-amino-7-oxononanoate synthase (AONS) (EC 2.3.1.47) (7-keto-8-amino-pelargonic acid synthase) (7-KAP synthase) (KAPA synthase) (8-amino-7-ketopelargonate synthase) (Alpha-oxoamine synthase) HP_0598 Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) TR40113_c1_g1_i2 Q9P2T1 GMPR2_HUMAN 0 GO:0003920; GO:0005829; GO:0046872; GO:0009117; GO:0006144; GO:0043101 GMP reductase activity; cytosol; metal ion binding; nucleotide metabolic process; purine nucleobase metabolic process; purine-containing compound salvage IPR013785; IPR005993; IPR015875; IPR001093; GMP reductase 2 (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2) GMPR2 Homo sapiens (Human) TR40113_c1_g1_i3 O16294 GMPR_CAEEL 3.00E-142 GO:0003920; GO:0046872; GO:0009117 GMP reductase activity; metal ion binding; nucleotide metabolic process IPR013785; IPR005993; IPR015875; IPR001093; Probable GMP reductase (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase) (Guanosine monophosphate reductase) F32D1.5 Caenorhabditis elegans TR40113_c1_g1_i4 B5YZD9 GUAC_ECO5E 5.00E-139 GO:0003920; GO:0046872; GO:0006163 GMP reductase activity; metal ion binding; purine nucleotide metabolic process IPR013785; IPR005993; IPR015875; IPR001093; GMP reductase (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase) (Guanosine monophosphate reductase) guaC ECH74115_0111 Escherichia coli O157:H7 (strain EC4115 / EHEC) TR40113_c1_g1_i5 Q32L93 GMPR2_BOVIN 6.00E-167 GO:0003920; GO:0046872; GO:0009117 GMP reductase activity; metal ion binding; nucleotide metabolic process IPR013785; IPR005993; IPR015875; IPR001093; GMP reductase 2 (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2) GMPR2 Bos taurus (Bovine) TR40113_c1_g1_i6 P21879 IMDH_BACSU 3.00E-46 GO:0006177; GO:0003938; GO:0030554; GO:0046872 GMP biosynthetic process; IMP dehydrogenase activity; adenyl nucleotide binding; metal ion binding IPR013785; IPR000644; IPR005990; IPR015875; IPR001093; Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1. Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPD) (IMPDH) (EC 1.1.1.205) (Superoxide-inducible protein 12) (SOI12) guaB gnaB BSU00090 Bacillus subtilis (strain 168) TR40113_c1_g1_i7 Q9P2T1 GMPR2_HUMAN 8.00E-168 GO:0003920; GO:0005829; GO:0046872; GO:0009117; GO:0006144; GO:0043101 GMP reductase activity; cytosol; metal ion binding; nucleotide metabolic process; purine nucleobase metabolic process; purine-containing compound salvage IPR013785; IPR005993; IPR015875; IPR001093; GMP reductase 2 (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2) GMPR2 Homo sapiens (Human) TR40113_c1_g1_i8 Q9P2T1 GMPR2_HUMAN 0 GO:0003920; GO:0005829; GO:0046872; GO:0009117; GO:0006144; GO:0043101 GMP reductase activity; cytosol; metal ion binding; nucleotide metabolic process; purine nucleobase metabolic process; purine-containing compound salvage IPR013785; IPR005993; IPR015875; IPR001093; GMP reductase 2 (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2) GMPR2 Homo sapiens (Human) TR40115_c3_g1_i2 Q5F485 DDX42_CHICK 0 GO:0005524; GO:0008026; GO:0003723; GO:0005737; GO:0005634; GO:0008104 ATP binding; ATP-dependent helicase activity; RNA binding; cytoplasm; nucleus; protein localization IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) DDX42 RCJMB04_2e15 Gallus gallus (Chicken) TR40117_c0_g1_i2 O61122 SVKA_DICDI 1.00E-12 GO:0005524; GO:0015629; GO:0007049; GO:0051301; GO:0005813; GO:0032154; GO:0005737; GO:0005829; GO:0006972; GO:0046872; GO:0005634; GO:0051781; GO:0046777; GO:0004674; GO:0032956; GO:0010590; GO:0031156; GO:0005819 ATP binding; actin cytoskeleton; cell cycle; cell division; centrosome; cleavage furrow; cytoplasm; cytosol; hyperosmotic response; metal ion binding; nucleus; positive regulation of cell division; protein autophosphorylation; protein serine/threonine kinase activity; regulation of actin cytoskeleton organization; regulation of cytokinetic cell separation; regulation of sorocarp development; spindle IPR009652; IPR011009; IPR000719; IPR017441; IPR002290; Serine/threonine-protein kinase svkA (EC 2.7.11.1) (Severin kinase A) svkA DDB_G0286359 Dictyostelium discoideum (Slime mold) TR40117_c0_g1_i4 Q5E9J9 STRAA_BOVIN 1.00E-55 GO:0005524; GO:0032147; GO:0007049; GO:0005737; GO:0005634; GO:0006611; GO:0030295; GO:0004672 ATP binding; activation of protein kinase activity; cell cycle; cytoplasm; nucleus; protein export from nucleus; protein kinase activator activity; protein kinase activity IPR011009; IPR000719; STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) STRADA LYK5 STRAD Bos taurus (Bovine) TR40117_c0_g2_i1 Q4R6X5 STRAA_MACFA 5.00E-46 GO:0005524; GO:0032147; GO:0007049; GO:0005737; GO:0005634; GO:0006611; GO:0030295; GO:0004672 ATP binding; activation of protein kinase activity; cell cycle; cytoplasm; nucleus; protein export from nucleus; protein kinase activator activity; protein kinase activity IPR011009; IPR000719; STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) STRADA STRAD QtsA-16929 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR40117_c0_g2_i3 Q8K4T3 STRAB_MOUSE 6.00E-33 GO:0005524; GO:0007254; GO:0032147; GO:0007049; GO:0000902; GO:0005737; GO:0007010; GO:2001240; GO:0005634; GO:0006611; GO:0004672 ATP binding; JNK cascade; activation of protein kinase activity; cell cycle; cell morphogenesis; cytoplasm; cytoskeleton organization; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; nucleus; protein export from nucleus; protein kinase activity IPR011009; IPR000719; STE20-related kinase adapter protein beta (STRAD beta) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase) (Pseudokinase ALS2CR2) Stradb Als2cr2 Papk Syradb Mus musculus (Mouse) TR40118_c0_g1_i1 B2UKY5 MDH_AKKM8 4.00E-110 GO:0030060; GO:0044262; GO:0006108; GO:0006099 L-malate dehydrogenase activity; cellular carbohydrate metabolic process; malate metabolic process; tricarboxylic acid cycle IPR001557; IPR022383; IPR001236; IPR015955; IPR001252; IPR010945; IPR016040; Malate dehydrogenase (EC 1.1.1.37) mdh Amuc_1436 Akkermansia muciniphila (strain ATCC BAA-835) TR40118_c0_g1_i4 Q3T145 MDHC_BOVIN 7.00E-159 GO:0030060; GO:0044262; GO:0005737; GO:0006108; GO:0006099 L-malate dehydrogenase activity; cellular carbohydrate metabolic process; cytoplasm; malate metabolic process; tricarboxylic acid cycle IPR001557; IPR022383; IPR001236; IPR015955; IPR001252; IPR011274; IPR010945; IPR016040; "Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Cytosolic malate dehydrogenase)" MDH1 Bos taurus (Bovine) TR40119_c1_g3_i1 Q6DFV8 VWDE_MOUSE 2.00E-13 GO:0005576 extracellular region IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) TR40119_c1_g3_i2 Q8N2E2 VWDE_HUMAN 2.00E-12 GO:0005576 extracellular region IPR000742; IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) TR40119_c1_g3_i3 O88572 LRP6_MOUSE 8.00E-06 GO:0044332; GO:0021874; GO:0090244; GO:0042813; GO:0090245; GO:0046849; GO:0060444; GO:0061310; GO:0061324; GO:0005901; GO:0042074; GO:0009986; GO:0071397; GO:0021587; GO:0021795; GO:0060026; GO:0015026; GO:0071936; GO:0031410; GO:0071542; GO:0005769; GO:0048596; GO:0042733; GO:0035115; GO:0035116; GO:0009880; GO:0060059; GO:0005783; GO:0035261; GO:0060325; GO:0021861; GO:0021943; GO:0001947; GO:0016021; GO:0019210; GO:0005041; GO:0060596; GO:0030901; GO:0030917; GO:0050680; GO:0045599; GO:2000151; GO:2000162; GO:2000168; GO:2000164; GO:2000166; GO:2000149; GO:0071901; GO:0034392; GO:0014029; GO:0001843; GO:0043025; GO:0042475; GO:0060021; GO:0003344; GO:2000055; GO:0043065; GO:0045780; GO:0090263; GO:0045787; GO:0002053; GO:0045778; GO:0051091; GO:0045944; GO:0036342; GO:0090009; GO:0043235; GO:0090118; GO:0060284; GO:0051593; GO:0048705; GO:0045202; GO:0007268; GO:0021794; GO:0019534; GO:0060535 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt receptor signaling pathway involved in forebrain neuroblast division; Wnt receptor signaling pathway involved in somitogenesis; Wnt-activated receptor activity; axis elongation involved in somitogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development; canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; caveola; cell migration involved in gastrulation; cell surface; cellular response to cholesterol; cerebellum morphogenesis; cerebral cortex cell migration; convergent extension; coreceptor activity; coreceptor activity involved in Wnt receptor signaling pathway; cytoplasmic vesicle; dopaminergic neuron differentiation; early endosome; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic pattern specification; embryonic retina morphogenesis in camera-type eye; endoplasmic reticulum; external genitalia morphogenesis; face morphogenesis; forebrain radial glial cell differentiation; formation of radial glial scaffolds; heart looping; integral to membrane; kinase inhibitor activity; low-density lipoprotein receptor activity; mammary placode formation; midbrain development; midbrain-hindbrain boundary development; negative regulation of epithelial cell proliferation; negative regulation of fat cell differentiation; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis; negative regulation of planar cell polarity pathway involved in neural tube closure; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest formation; neural tube closure; neuronal cell body; odontogenesis of dentin-containing tooth; palate development; pericardium morphogenesis; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell cycle; positive regulation of mesenchymal cell proliferation; positive regulation of ossification; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; post-anal tail morphogenesis; primitive streak formation; receptor complex; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport; regulation of cell development; response to folic acid; skeletal system morphogenesis; synapse; synaptic transmission; thalamus development; toxin transporter activity; trachea cartilage morphogenesis IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 6 (LRP-6) Lrp6 Mus musculus (Mouse) TR40121_c2_g2_i1 Q64419 EST1_MESAU 3.00E-65 GO:0004091; GO:0005788 carboxylesterase activity; endoplasmic reticulum lumen IPR002018; IPR019826; IPR019819; Liver carboxylesterase (EC 3.1.1.1) Mesocricetus auratus (Golden hamster) TR40121_c2_g2_i2 Q04791 SASB_ANAPL 4.00E-73 GO:0006633; GO:0016787 fatty acid biosynthetic process; hydrolase activity IPR002018; IPR019826; IPR019819; "Fatty acyl-CoA hydrolase precursor, medium chain (EC 3.1.2.-) (Thioesterase B)" Anas platyrhynchos (Domestic duck) (Anas boschas) TR40121_c2_g2_i3 Q64419 EST1_MESAU 2.00E-66 GO:0004091; GO:0005788 carboxylesterase activity; endoplasmic reticulum lumen IPR002018; IPR019826; IPR019819; Liver carboxylesterase (EC 3.1.1.1) Mesocricetus auratus (Golden hamster) TR40121_c2_g2_i4 Q9UKY3 CES1P_HUMAN 1.00E-51 GO:0009653; GO:0004091; GO:0005783; GO:0005576 anatomical structure morphogenesis; carboxylesterase activity; endoplasmic reticulum; extracellular region IPR002018; IPR019819; Putative inactive carboxylesterase 4 (Inactive carboxylesterase 1 pseudogene 1) (Placental carboxylesterase 3) (PCE-3) CES1P1 CES4 Homo sapiens (Human) TR40121_c2_g2_i5 P56161 ACES_ANOST 5.00E-25 GO:0001507; GO:0003990; GO:0031225; GO:0004091; GO:0030054; GO:0005886; GO:0045202 acetylcholine catabolic process in synaptic cleft; acetylcholinesterase activity; anchored to membrane; carboxylesterase activity; cell junction; plasma membrane; synapse IPR001445; IPR002018; IPR019826; IPR019819; IPR000997; Acetylcholinesterase (AChE) (EC 3.1.1.7) Anopheles stephensi (Indo-Pakistan malaria mosquito) TR40123_c1_g1_i1 Q6DF62 RGN_XENTR 2.00E-84 GO:0019853; GO:0005509; GO:0006874; GO:0005737; GO:0030234; GO:0004341; GO:0005634; GO:0032781; GO:0050848; GO:0008270 L-ascorbic acid biosynthetic process; calcium ion binding; cellular calcium ion homeostasis; cytoplasm; enzyme regulator activity; gluconolactonase activity; nucleus; positive regulation of ATPase activity; regulation of calcium-mediated signaling; zinc ion binding IPR011042; IPR008367; IPR013658; IPR005511; Cofactor biosynthesis; L-ascorbate biosynthesis via UDP-alpha-D-glucuronate pathway; L-ascorbate from UDP-alpha-D-glucuronate: step 3/4. Regucalcin (RC) (Gluconolactonase) (GNL) (EC 3.1.1.17) rgn Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40123_c2_g2_i1 A5D8Q0 XIAP_XENLA 6.00E-10 GO:0016055; GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0045861; GO:0090263; GO:0008270 Wnt receptor signaling pathway; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; negative regulation of proteolysis; positive regulation of canonical Wnt receptor signaling pathway; zinc ion binding IPR001370; IPR001841; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (xXIAP) xiap birc4 Xenopus laevis (African clawed frog) TR40123_c2_g2_i2 Q197D9 VF193_IIV3 5.00E-06 GO:0006915; GO:0039650; GO:0008270 apoptotic process; suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process; zinc ion binding IPR001841; IPR013083; Putative apoptosis inhibitor 021L IIV3-021L Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus) TR40123_c2_g3_i1 Q8WZ73 RFFL_HUMAN 9.00E-07 GO:0006915; GO:0016023; GO:0006886; GO:0016020; GO:0043161; GO:0070936; GO:0032006; GO:0010762; GO:0004842; GO:0008270 apoptotic process; cytoplasmic membrane-bounded vesicle; intracellular protein transport; membrane; proteasomal ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; regulation of TOR signaling cascade; regulation of fibroblast migration; ubiquitin-protein ligase activity; zinc ion binding IPR011011; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase rififylin (EC 6.3.2.-) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) RFFL RNF189 RNF34L Homo sapiens (Human) TR40123_c2_g4_i1 O62640 PIAP_PIG 1.00E-33 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR40123_c2_g4_i4 Q8JHV9 BIR7A_XENLA 5.00E-30 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR40123_c2_g4_i5 Q95M71 BIRC8_GORGO 1.00E-22 GO:0006915; GO:0005737; GO:0008270 apoptotic process; cytoplasm; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis-like protein 2) (IAP-like protein 2) (ILP-2) BIRC8 ILP2 Gorilla gorilla gorilla (Lowland gorilla) TR40123_c2_g4_i8 O62640 PIAP_PIG 1.00E-34 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR40123_c2_g4_i9 Q96CA5 BIRC7_HUMAN 7.00E-18 GO:0005794; GO:0007257; GO:0006309; GO:0004869; GO:0019899; GO:0043066; GO:0005634; GO:0042127; GO:0070247; GO:0004842; GO:0008270 P55211; Q9NR28; O43464 Golgi apparatus; activation of JUN kinase activity; apoptotic DNA fragmentation; cysteine-type endopeptidase inhibitor activity; enzyme binding; negative regulation of apoptotic process; nucleus; regulation of cell proliferation; regulation of natural killer cell apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; IPR017907; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)] BIRC7 KIAP LIVIN MLIAP RNF50 UNQ5800/PRO19607/PRO21344 Homo sapiens (Human) TR40125_c0_g1_i1 P56649 G3P_PANVR 0 GO:0051287; GO:0050661; GO:0005737; GO:0004365; GO:0006096 NAD binding; NADP binding; cytoplasm; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; glycolysis IPR020831; IPR020830; IPR020829; IPR020828; IPR006424; IPR016040; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) Panulirus versicolor (Spiny blue lobster) (Palinurus versicolor) TR40125_c0_g1_i2 P00357 G3P_HOMAM 0 GO:0051287; GO:0050661; GO:0005737; GO:0004365; GO:0006096 NAD binding; NADP binding; cytoplasm; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; glycolysis IPR020831; IPR020830; IPR020829; IPR020828; IPR006424; IPR016040; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) Homarus americanus (American lobster) TR40126_c0_g1_i2 B3RFR8 HYDMA_HYDVU 9.00E-21 GO:0042742; GO:0045087; GO:0016020; GO:0044218 defense response to bacterium; innate immune response; membrane; other organism cell membrane Hydramacin-1 (Hm-1) Hydra vulgaris (Hydra) (Hydra attenuata) TR40129_c1_g3_i3 Q63931 CCKAR_CAVPO 2.00E-06 GO:0004951; GO:0038188; GO:0016021; GO:0005886 cholecystokinin receptor activity; cholecystokinin signaling pathway; integral to membrane; plasma membrane IPR009126; IPR000596; IPR015276; IPR000276; IPR017452; Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR Cavia porcellus (Guinea pig) TR40129_c1_g3_i4 Q63931 CCKAR_CAVPO 4.00E-06 GO:0004951; GO:0038188; GO:0016021; GO:0005886 cholecystokinin receptor activity; cholecystokinin signaling pathway; integral to membrane; plasma membrane IPR009126; IPR000596; IPR015276; IPR000276; IPR017452; Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR Cavia porcellus (Guinea pig) TR4013_c0_g1_i1 Q5D016 PFD1_DANRE 1.00E-25 GO:0016272; GO:0006457 prefoldin complex; protein folding IPR002777; IPR009053; Prefoldin subunit 1 pfdn1 zgc:110742 Danio rerio (Zebrafish) (Brachydanio rerio) TR40131_c0_g1_i1 Q99615 DNJC7_HUMAN 1.00E-175 GO:0070389; GO:0005737; GO:0005856; GO:0005634 P12504 chaperone cofactor-dependent protein refolding; cytoplasm; cytoskeleton; nucleus IPR001623; IPR013026; IPR011990; IPR001440; IPR013105; IPR019734; DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2) DNAJC7 TPR2 TTC2 Homo sapiens (Human) TR40131_c2_g1_i2 Q7TNE3 SPAG7_MOUSE 7.00E-65 GO:0003676; GO:0005634 nucleic acid binding; nucleus IPR001374; IPR017330; Sperm-associated antigen 7 Spag7 Mus musculus (Mouse) TR40135_c1_g1_i1 O18638 OAF_DROVI 2.00E-69 GO:0007275 multicellular organismal development IPR026315; Out at first protein oaf Drosophila virilis (Fruit fly) TR40136_c1_g3_i2 O15990 KARG_LIOJA 5.00E-168 GO:0005524; GO:0004054 ATP binding; arginine kinase activity IPR022415; IPR022414; IPR022413; IPR014746; Arginine kinase (AK) (EC 2.7.3.3) Liolophura japonica (Chiton) (Acanthopleura japonica) TR40136_c1_g3_i3 O15990 KARG_LIOJA 5.00E-169 GO:0005524; GO:0004054 ATP binding; arginine kinase activity IPR022415; IPR022414; IPR022413; IPR014746; Arginine kinase (AK) (EC 2.7.3.3) Liolophura japonica (Chiton) (Acanthopleura japonica) TR40138_c2_g1_i1 C3NDZ8 FLPA_SULIY 4.00E-58 GO:0003723; GO:0008168; GO:0006364; GO:0008033 RNA binding; methyltransferase activity; rRNA processing; tRNA processing IPR000692; IPR020813; Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase (EC 2.1.1.-) flpA YG5714_1271 Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) TR40138_c2_g1_i13 P22232 FBRL_XENLA 9.00E-142 GO:0003723; GO:0008168; GO:0005730; GO:0006364; GO:0030529; GO:0008033 RNA binding; methyltransferase activity; nucleolus; rRNA processing; ribonucleoprotein complex; tRNA processing IPR000692; IPR020813; rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) fbl Xenopus laevis (African clawed frog) TR40138_c2_g1_i14 P22232 FBRL_XENLA 3.00E-142 GO:0003723; GO:0008168; GO:0005730; GO:0006364; GO:0030529; GO:0008033 RNA binding; methyltransferase activity; nucleolus; rRNA processing; ribonucleoprotein complex; tRNA processing IPR000692; IPR020813; rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) fbl Xenopus laevis (African clawed frog) TR40138_c2_g1_i5 P22232 FBRL_XENLA 2.00E-143 GO:0003723; GO:0008168; GO:0005730; GO:0006364; GO:0030529; GO:0008033 RNA binding; methyltransferase activity; nucleolus; rRNA processing; ribonucleoprotein complex; tRNA processing IPR000692; IPR020813; rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) fbl Xenopus laevis (African clawed frog) TR40138_c2_g1_i9 Q9FEF8 MD36B_ARATH 8.00E-126 GO:0001510; GO:0016020; GO:0008168; GO:0005730; GO:0006364; GO:0006355; GO:0030529; GO:0030515; GO:0008033; GO:0006351 "RNA methylation; membrane; methyltransferase activity; nucleolus; rRNA processing; regulation of transcription, DNA-dependent; ribonucleoprotein complex; snoRNA binding; tRNA processing; transcription, DNA-dependent" IPR000692; Probable mediator of RNA polymerase II transcription subunit 36b (SKP1-interacting partner 7) (rRNA 2'-O-methyltransferase fibrillarin 1) (EC 2.1.1.-) MED36B FBR1 FIB1 MED36_2 SKIP7 At5g52470 K24M7.22 Arabidopsis thaliana (Mouse-ear cress) TR40141_c0_g4_i2 Q7TPD1 FBX11_MOUSE 0 GO:0005694; GO:0005634; GO:0007605; GO:0004842; GO:0008270 chromosome; nucleus; sensory perception of sound; ubiquitin-protein ligase activity; zinc ion binding IPR006633; IPR001810; IPR022441; IPR006626; IPR012334; IPR011050; IPR003126; Protein modification; protein ubiquitination. F-box only protein 11 Fbxo11 Mus musculus (Mouse) TR40141_c0_g4_i3 Q86XK2 FBX11_HUMAN 0 GO:0005694; GO:0005737; GO:0005730; GO:0016274; GO:0007605; GO:0000151; GO:0006511; GO:0004842; GO:0008270 P63208; P04637 chromosome; cytoplasm; nucleolus; protein-arginine N-methyltransferase activity; sensory perception of sound; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR006633; IPR001810; IPR022441; IPR006626; IPR012334; IPR011050; IPR003126; Protein modification; protein ubiquitination. F-box only protein 11 (Protein arginine N-methyltransferase 9) (Vitiligo-associated protein 1) (VIT-1) FBXO11 FBX11 PRMT9 VIT1 UG063H01 Homo sapiens (Human) TR40141_c0_g4_i4 B9G2A8 BIG_ORYSJ 2.00E-09 GO:0009734; GO:0009926; GO:0016021; GO:0007275; GO:0016567; GO:0004842; GO:0009826; GO:0008270 auxin mediated signaling pathway; auxin polar transport; integral to membrane; multicellular organismal development; protein ubiquitination; ubiquitin-protein ligase activity; unidimensional cell growth; zinc ion binding IPR016024; IPR025704; IPR003126; IPR000433; Auxin transport protein BIG Os09g0247700 LOC_Os09g07294 OJ1451_A02.25 OsJ_28507 P0499G10.6 Oryza sativa subsp. japonica (Rice) TR40142_c0_g2_i1 Q575T0 CYGB1_ORYLA 4.00E-07 GO:0005737; GO:0020037; GO:0005506; GO:0019825; GO:0005344 cytoplasm; heme binding; iron ion binding; oxygen binding; oxygen transporter activity IPR000971; IPR009050; IPR012292; IPR013314; Cytoglobin-1 cygb1 cygb-1 Oryzias latipes (Medaka fish) (Japanese ricefish) TR40142_c0_g2_i2 Q575T0 CYGB1_ORYLA 1.00E-09 GO:0005737; GO:0020037; GO:0005506; GO:0019825; GO:0005344 cytoplasm; heme binding; iron ion binding; oxygen binding; oxygen transporter activity IPR000971; IPR009050; IPR012292; IPR013314; Cytoglobin-1 cygb1 cygb-1 Oryzias latipes (Medaka fish) (Japanese ricefish) TR40144_c4_g1_i1 Q8BR07 BICD1_MOUSE 1.00E-51 GO:0005794; GO:0005881; GO:0031410; GO:0005829; GO:0072517; GO:0016020; GO:0072393; GO:0072385; GO:1900275; GO:1900737; GO:0048471; GO:0048260; GO:0033365; GO:1900276; GO:0034063; GO:0005802; GO:0016032 Golgi apparatus; cytoplasmic microtubule; cytoplasmic vesicle; cytosol; host cell viral assembly compartment; membrane; microtubule anchoring at microtubule organizing center; minus-end-directed organelle transport along microtubule; negative regulation of phospholipase C activity; negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway; perinuclear region of cytoplasm; positive regulation of receptor-mediated endocytosis; protein localization to organelle; regulation of proteinase activated receptor activity; stress granule assembly; trans-Golgi network; viral process IPR018477; Protein bicaudal D homolog 1 (Bic-D 1) Bicd1 Mus musculus (Mouse) TR40145_c2_g1_i1 Q7T2Z5 UNC5C_CHICK 7.00E-91 GO:0016021; GO:0007275; GO:0007165 integral to membrane; multicellular organismal development; signal transduction IPR011029; IPR000488; IPR007110; IPR013783; IPR013098; IPR003598; IPR000884; IPR000906; Netrin receptor UNC5C (Protein unc-5 homolog 3) (cUNC-5H3) (Protein unc-5 homolog C) UNC5C Gallus gallus (Chicken) TR40145_c2_g2_i1 Q8K1S3 UNC5B_MOUSE 1.00E-71 GO:0033564; GO:0006915; GO:0005829; GO:0016021; GO:2001240; GO:0005886; GO:0007165 Q7TNP2 anterior/posterior axon guidance; apoptotic process; cytosol; integral to membrane; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; plasma membrane; signal transduction IPR011029; IPR000488; IPR007110; IPR013783; IPR013098; IPR003598; IPR000884; IPR000906; Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) Unc5b Unc5h2 Mus musculus (Mouse) TR40146_c3_g2_i1 Q9CY97 SSU72_MOUSE 6.00E-34 GO:0008420; GO:0005737; GO:0070940; GO:0006378; GO:0005634 CTD phosphatase activity; cytoplasm; dephosphorylation of RNA polymerase II C-terminal domain; mRNA polyadenylation; nucleus IPR006811; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (CTD phosphatase SSU72) (EC 3.1.3.16) Ssu72 Mus musculus (Mouse) TR40146_c3_g2_i4 Q5ZJQ7 SSU72_CHICK 4.00E-101 GO:0008420; GO:0005737; GO:0070940; GO:0006378; GO:0005634 CTD phosphatase activity; cytoplasm; dephosphorylation of RNA polymerase II C-terminal domain; mRNA polyadenylation; nucleus IPR006811; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (CTD phosphatase SSU72) (EC 3.1.3.16) SSU72 RCJMB04_16f24 Gallus gallus (Chicken) TR40147_c0_g1_i1 P17304 ACTM_APLCA 5.00E-137 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin, muscle" Aplysia californica (California sea hare) TR40147_c0_g1_i2 Q9C9B2 ARP4A_ARATH 1.00E-23 IPR004000; Actin-related protein 4A (Actin-related protein 5) ARP4A ARP5 At1g73910 F2P9.22 Arabidopsis thaliana (Mouse-ear cress) TR40150_c4_g1_i1 P27615 SCRB2_RAT 2.00E-65 GO:0007155; GO:0016021; GO:0043202; GO:0005765; GO:0006622; GO:0004872 cell adhesion; integral to membrane; lysosomal lumen; lysosomal membrane; protein targeting to lysosome; receptor activity IPR002159; IPR005429; Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36) Scarb2 Cd36l2 Limpii Rattus norvegicus (Rat) TR40150_c4_g3_i3 P27615 SCRB2_RAT 2.00E-58 GO:0007155; GO:0016021; GO:0043202; GO:0005765; GO:0006622; GO:0004872 cell adhesion; integral to membrane; lysosomal lumen; lysosomal membrane; protein targeting to lysosome; receptor activity IPR002159; IPR005429; Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36) Scarb2 Cd36l2 Limpii Rattus norvegicus (Rat) TR40152_c2_g3_i1 Q9NPH0 PPA6_HUMAN 3.00E-46 GO:0003993; GO:0005576; GO:2001311; GO:0052642; GO:0005739 acid phosphatase activity; extracellular region; lysobisphosphatidic acid metabolic process; lysophosphatidic acid phosphatase activity; mitochondrion IPR000560; "Lysophosphatidic acid phosphatase type 6 (EC 3.1.3.2) (Acid phosphatase 6, lysophosphatidic) (Acid phosphatase-like protein 1) (PACPL1)" ACP6 ACPL1 LPAP UNQ205/PRO231 Homo sapiens (Human) TR40152_c2_g3_i2 Q10944 PHO5_CAEEL 3.00E-09 GO:0003993 acid phosphatase activity IPR000560; Putative acid phosphatase 5 (EC 3.1.3.2) pho-5 B0361.7 Caenorhabditis elegans TR40152_c2_g3_i3 Q54PR9 CF60_DICDI 1.00E-31 GO:0005576; GO:0031158 extracellular region; negative regulation of aggregate size involved in sorocarp development IPR000560; Counting factor 60 cf60 DDB_G0284363 Dictyostelium discoideum (Slime mold) TR40152_c2_g3_i4 Q9NPH0 PPA6_HUMAN 8.00E-46 GO:0003993; GO:0005576; GO:2001311; GO:0052642; GO:0005739 acid phosphatase activity; extracellular region; lysobisphosphatidic acid metabolic process; lysophosphatidic acid phosphatase activity; mitochondrion IPR000560; "Lysophosphatidic acid phosphatase type 6 (EC 3.1.3.2) (Acid phosphatase 6, lysophosphatidic) (Acid phosphatase-like protein 1) (PACPL1)" ACP6 ACPL1 LPAP UNQ205/PRO231 Homo sapiens (Human) TR40157_c0_g3_i1 Q3U2U7 MET17_MOUSE 1.00E-40 GO:0005507; GO:0008168; GO:0005739; GO:0005840; GO:0006412 copper ion binding; methyltransferase activity; mitochondrion; ribosome; translation IPR007533; IPR015324; "Methyltransferase-like protein 17, mitochondrial (EC 2.1.1.-) (Methyltransferase 11 domain-containing protein 1) (Protein RSM22 homolog, mitochondrial)" Mettl17 D14Ertd209e Mett11d1 Mus musculus (Mouse) TR40158_c22_g1_i1 P07686 HEXB_HUMAN 6.00E-41 GO:0001669; GO:0043615; GO:0004563; GO:0005975; GO:0008219; GO:0006874; GO:0044267; GO:0030207; GO:0006689; GO:0006687; GO:0030214; GO:0042340; GO:0019915; GO:0007626; GO:0043202; GO:0007040; GO:0008049; GO:0016020; GO:0042552; GO:0050885; GO:0009313; GO:0048477; GO:0007341; GO:0008654; GO:0045944; GO:0046982; GO:0042803; GO:0008360; GO:0007605; GO:0001501 acrosomal vesicle; astrocyte cell migration; beta-N-acetylhexosaminidase activity; carbohydrate metabolic process; cell death; cellular calcium ion homeostasis; cellular protein metabolic process; chondroitin sulfate catabolic process; ganglioside catabolic process; glycosphingolipid metabolic process; hyaluronan catabolic process; keratan sulfate catabolic process; lipid storage; locomotory behavior; lysosomal lumen; lysosome organization; male courtship behavior; membrane; myelination; neuromuscular process controlling balance; oligosaccharide catabolic process; oogenesis; penetration of zona pellucida; phospholipid biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; protein homodimerization activity; regulation of cell shape; sensory perception of sound; skeletal system development IPR025705; IPR015883; IPR013781; IPR017853; Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] HEXB HCC7 Homo sapiens (Human) TR40159_c3_g1_i1 Q503L9 NXN_DANRE 7.00E-50 GO:0016055; GO:0072358; GO:0030154; GO:0005829; GO:0030178; GO:0031397; GO:0005634; GO:0047134 Wnt receptor signaling pathway; cardiovascular system development; cell differentiation; cytosol; negative regulation of Wnt receptor signaling pathway; negative regulation of protein ubiquitination; nucleus; protein-disulfide reductase activity IPR012336; Nucleoredoxin (EC 1.8.1.8) nxn zgc:110449 Danio rerio (Zebrafish) (Brachydanio rerio) TR40159_c3_g1_i2 O77404 TYPX_TRYBB 6.00E-33 GO:0045454; GO:0055114 cell redox homeostasis; oxidation-reduction process IPR012336; IPR017937; Tryparedoxin (TryX) Trypanosoma brucei brucei TR40159_c4_g2_i1 A2AM29 AF9_MOUSE 3.00E-55 GO:0009952; GO:0090090; GO:0005634; GO:2000096; GO:0006355; GO:0007379; GO:0006351 "anterior/posterior pattern specification; negative regulation of canonical Wnt receptor signaling pathway; nucleus; positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway; regulation of transcription, DNA-dependent; segment specification; transcription, DNA-dependent" IPR005033; Protein AF-9 (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog) Mllt3 Af9 Mus musculus (Mouse) TR40159_c4_g2_i3 Q755P0 AF9_ASHGO 9.00E-20 GO:0006281; GO:0035267; GO:0000812; GO:0006348; GO:0005737; GO:0043486; GO:0006351 "DNA repair; NuA4 histone acetyltransferase complex; Swr1 complex; chromatin silencing at telomere; cytoplasm; histone exchange; transcription, DNA-dependent" IPR005033; Protein AF-9 homolog YAF9 AFL227C Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR40160_c0_g1_i11 Q9DBS2 TPRGL_MOUSE 7.00E-46 GO:0030054; GO:0008021 cell junction; synaptic vesicle IPR022158; Tumor protein p63-regulated gene 1-like protein (Mossy fiber terminal-associated vertebrate-specific presynaptic protein) (Protein FAM79A) Tprg1l Fam79a Mover Tprgl Mus musculus (Mouse) TR40160_c0_g1_i13 Q5T0D9 TPRGL_HUMAN 1.00E-46 GO:0030054; GO:0008021 cell junction; synaptic vesicle IPR022158; Tumor protein p63-regulated gene 1-like protein (Mossy fiber terminal-associated vertebrate-specific presynaptic protein) (Protein FAM79A) TPRG1L FAM79A MOVER Homo sapiens (Human) TR40160_c0_g1_i5 Q5T0D9 TPRGL_HUMAN 9.00E-46 GO:0030054; GO:0008021 cell junction; synaptic vesicle IPR022158; Tumor protein p63-regulated gene 1-like protein (Mossy fiber terminal-associated vertebrate-specific presynaptic protein) (Protein FAM79A) TPRG1L FAM79A MOVER Homo sapiens (Human) TR40161_c0_g1_i1 C4A0P0 CID2B_BRAFL 6.00E-49 GO:0051537; GO:0005789; GO:0016021; GO:0046872 "2 iron, 2 sulfur cluster binding; endoplasmic reticulum membrane; integral to membrane; metal ion binding" IPR018967; IPR006622; IPR019610; CDGSH iron-sulfur domain-containing protein 2 homolog B BRAFLDRAFT_274541 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR40161_c0_g1_i3 C1C524 CISD2_LITCT 3.00E-46 GO:0051537; GO:0005789; GO:0016021; GO:0046872; GO:0005741; GO:0000422; GO:0010259; GO:0042803; GO:0010506 "2 iron, 2 sulfur cluster binding; endoplasmic reticulum membrane; integral to membrane; metal ion binding; mitochondrial outer membrane; mitochondrion degradation; multicellular organismal aging; protein homodimerization activity; regulation of autophagy" IPR018967; IPR006622; IPR019610; CDGSH iron-sulfur domain-containing protein 2 cisd2 Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) TR40162_c0_g1_i1 Q6P5H6 FRMD5_MOUSE 2.00E-106 GO:0005737; GO:0005856; GO:0019898 cytoplasm; cytoskeleton; extrinsic to membrane IPR019749; IPR019750; IPR000798; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; FERM domain-containing protein 5 Frmd5 Mus musculus (Mouse) TR40162_c0_g1_i4 Q6P5H6 FRMD5_MOUSE 5.00E-108 GO:0005737; GO:0005856; GO:0019898 cytoplasm; cytoskeleton; extrinsic to membrane IPR019749; IPR019750; IPR000798; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; FERM domain-containing protein 5 Frmd5 Mus musculus (Mouse) TR40163_c1_g1_i1 Q557E7 CBLA_DICDI 7.00E-08 GO:0005509; GO:0005829; GO:0007243; GO:0016874; GO:0005634; GO:0016567; GO:0030587; GO:0008270 calcium ion binding; cytosol; intracellular protein kinase cascade; ligase activity; nucleus; protein ubiquitination; sorocarp development; zinc ion binding IPR014741; IPR024159; IPR011992; IPR000980; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase cblA (EC 6.3.2.-) (Cbl-like protein A) (RING finger protein cblA) cblA-1 DDB_G0273141; cblA-2 DDB_G0273609 Dictyostelium discoideum (Slime mold) TR40163_c1_g1_i2 Q804S5 MIB1_DANRE 5.00E-09 GO:0007219; GO:0005737; GO:0007275; GO:0005886; GO:0004842; GO:0008270 Notch signaling pathway; cytoplasm; multicellular organismal development; plasma membrane; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase mib1 (EC 6.3.2.-) (Protein mind bomb) mib1 mib Danio rerio (Zebrafish) (Brachydanio rerio) TR40163_c1_g2_i7 A1E2V0 BIRC3_CANFA 3.00E-34 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) BIRC3 Canis familiaris (Dog) (Canis lupus familiaris) TR40164_c0_g3_i5 A1L2F6 TM205_DANRE 3.00E-11 GO:0016021 integral to membrane IPR025423; Transmembrane protein 205 tmem205 zgc:158860 Danio rerio (Zebrafish) (Brachydanio rerio) TR40164_c0_g3_i9 A1L2F6 TM205_DANRE 4.00E-11 GO:0016021 integral to membrane IPR025423; Transmembrane protein 205 tmem205 zgc:158860 Danio rerio (Zebrafish) (Brachydanio rerio) TR40167_c1_g1_i1 Q9NTJ4 MA2C1_HUMAN 0 GO:0004559; GO:0030246; GO:0006013; GO:0008270 alpha-mannosidase activity; carbohydrate binding; mannose metabolic process; zinc ion binding IPR011013; IPR011330; IPR027291; IPR011682; IPR015341; IPR000602; Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha mannosidase 6A8B) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1) MAN2C1 MANA MANA1 Homo sapiens (Human) TR40169_c0_g1_i3 Q9DAN6 GTSF1_MOUSE 2.00E-19 GO:0005737; GO:0046872 cytoplasm; metal ion binding IPR022776; IPR007917; Gametocyte-specific factor 1 (Protein FAM112B) Gtsf1 Fam112b Mus musculus (Mouse) TR40169_c0_g1_i5 Q3SZU0 GTSF1_BOVIN 3.00E-18 GO:0046872 metal ion binding IPR022776; IPR007917; Gametocyte-specific factor 1 (Protein FAM112B) GTSF1 FAM112B Bos taurus (Bovine) TR40170_c4_g3_i3 Q6NX65 PDC10_RAT 3.00E-47 GO:0000139; GO:0001525; GO:0006915; GO:0005829; GO:0043066; GO:0005886; GO:0043406; GO:0008284 Golgi membrane; angiogenesis; apoptotic process; cytosol; negative regulation of apoptotic process; plasma membrane; positive regulation of MAP kinase activity; positive regulation of cell proliferation IPR009652; Programmed cell death protein 10 Pdcd10 Rattus norvegicus (Rat) TR40171_c2_g1_i1 P32306 OXYR_PIG 2.00E-17 GO:0016021; GO:0004990; GO:0005886; GO:0005000 integral to membrane; oxytocin receptor activity; plasma membrane; vasopressin receptor activity IPR000276; IPR017452; IPR002062; IPR001817; Oxytocin receptor (OT-R) OXTR Sus scrofa (Pig) TR40171_c2_g1_i10 Q9WTV8 V1AR_MICMA 3.00E-25 GO:0016021; GO:0005886; GO:0005000 integral to membrane; plasma membrane; vasopressin receptor activity IPR015076; IPR000276; IPR017452; IPR001817; IPR001224; Vasopressin V1a receptor (V1aR) (AVPR V1a) (Antidiuretic hormone receptor 1a) (Vascular/hepatic-type arginine vasopressin receptor) Avpr1a Microtus montanus (Montane vole) TR40171_c2_g1_i2 Q868T3 CCAPR_DROME 5.00E-25 GO:0018990; GO:0005887; GO:0008188; GO:0005000 "ecdysis, chitin-based cuticle; integral to plasma membrane; neuropeptide receptor activity; vasopressin receptor activity" IPR000276; IPR017452; IPR001817; Cardioacceleratory peptide receptor CcapR CG6111 Drosophila melanogaster (Fruit fly) TR40171_c2_g1_i4 P56449 OXYR_BOVIN 3.00E-08 GO:0016021; GO:0004990; GO:0005886; GO:0005000 integral to membrane; oxytocin receptor activity; plasma membrane; vasopressin receptor activity IPR000276; IPR017452; IPR002062; IPR001817; Oxytocin receptor (OT-R) OXTR Bos taurus (Bovine) TR40171_c2_g1_i5 P30560 V1AR_RAT 1.00E-24 GO:0031894; GO:0019722; GO:0042631; GO:0031410; GO:0030659; GO:0007204; GO:0007625; GO:0016021; GO:0002125; GO:0042711; GO:0014902; GO:0007621; GO:0051970; GO:0043084; GO:0017046; GO:0005886; GO:0030307; GO:0008284; GO:0032849; GO:0014049; GO:0045819; GO:0010460; GO:0031394; GO:0035815; GO:0003084; GO:0035810; GO:0045907; GO:0051459; GO:0001992; GO:0051412; GO:0035176; GO:0042713; GO:0021537; GO:0005000 V1A vasopressin receptor binding; calcium-mediated signaling; cellular response to water deprivation; cytoplasmic vesicle; cytoplasmic vesicle membrane; elevation of cytosolic calcium ion concentration; grooming behavior; integral to membrane; maternal aggressive behavior; maternal behavior; myotube differentiation; negative regulation of female receptivity; negative regulation of transmission of nerve impulse; penile erection; peptide hormone binding; plasma membrane; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cellular pH reduction; positive regulation of glutamate secretion; positive regulation of glycogen catabolic process; positive regulation of heart rate; positive regulation of prostaglandin biosynthetic process; positive regulation of renal sodium excretion; positive regulation of systemic arterial blood pressure; positive regulation of urine volume; positive regulation of vasoconstriction; regulation of corticotropin secretion; regulation of systemic arterial blood pressure by vasopressin; response to corticosterone stimulus; social behavior; sperm ejaculation; telencephalon development; vasopressin receptor activity IPR015076; IPR000276; IPR017452; IPR001817; IPR001224; Vasopressin V1a receptor (V1aR) (AVPR V1a) (Antidiuretic hormone receptor 1a) (Vascular/hepatic-type arginine vasopressin receptor) Avpr1a Rattus norvegicus (Rat) TR40171_c2_g1_i6 P48974 V1BR_RAT 2.00E-18 GO:0007188; GO:0007204; GO:0042538; GO:0016021; GO:0017046; GO:0005886; GO:0045777; GO:0032849; GO:0014049; GO:0010460; GO:0042803; GO:0005000 adenylate cyclase-modulating G-protein coupled receptor signaling pathway; elevation of cytosolic calcium ion concentration; hyperosmotic salinity response; integral to membrane; peptide hormone binding; plasma membrane; positive regulation of blood pressure; positive regulation of cellular pH reduction; positive regulation of glutamate secretion; positive regulation of heart rate; protein homodimerization activity; vasopressin receptor activity IPR015076; IPR000276; IPR017452; IPR001817; IPR000628; Vasopressin V1b receptor (V1bR) (AVPR V1b) (AVPR V3) (Antidiuretic hormone receptor 1b) (Vasopressin V3 receptor) Avpr1b Rattus norvegicus (Rat) TR40171_c2_g1_i7 Q868T3 CCAPR_DROME 9.00E-26 GO:0018990; GO:0005887; GO:0008188; GO:0005000 "ecdysis, chitin-based cuticle; integral to plasma membrane; neuropeptide receptor activity; vasopressin receptor activity" IPR000276; IPR017452; IPR001817; Cardioacceleratory peptide receptor CcapR CG6111 Drosophila melanogaster (Fruit fly) TR40171_c2_g1_i8 P56494 OXYR_MACMU 2.00E-17 GO:0016021; GO:0004990; GO:0005886; GO:0005000 integral to membrane; oxytocin receptor activity; plasma membrane; vasopressin receptor activity IPR000276; IPR017452; IPR002062; IPR001817; Oxytocin receptor (OT-R) OXTR Macaca mulatta (Rhesus macaque) TR40174_c1_g2_i1 P08953 TOLL_DROME 9.00E-11 GO:0033565; GO:0008063; GO:0019732; GO:0007155; GO:0019955; GO:0050830; GO:0005769; GO:0009897; GO:0007507; GO:0035172; GO:0030097; GO:0045087; GO:0016021; GO:0006963; GO:0006967; GO:0045610; GO:0007416; GO:0016201; GO:0004888; GO:0007352 Itself; Q7K105 ESCRT-0 complex; Toll signaling pathway; antifungal humoral response; cell adhesion; cytokine binding; defense response to Gram-positive bacterium; early endosome; external side of plasma membrane; heart development; hemocyte proliferation; hemopoiesis; innate immune response; integral to membrane; positive regulation of antibacterial peptide biosynthetic process; positive regulation of antifungal peptide biosynthetic process; regulation of hemocyte differentiation; synapse assembly; synaptic target inhibition; transmembrane signaling receptor activity; zygotic specification of dorsal/ventral axis IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) TR40174_c1_g2_i2 Q9WVC1 SLIT2_RAT 3.00E-10 GO:0007420; GO:0030154; GO:0006935; GO:0005576; GO:0004963; GO:0042699; GO:0043395; GO:0008201; GO:0016021; GO:0050728; GO:0090027; GO:0005886; GO:0031667; GO:0021510 brain development; cell differentiation; chemotaxis; extracellular region; follicle-stimulating hormone receptor activity; follicle-stimulating hormone signaling pathway; heparan sulfate proteoglycan binding; heparin binding; integral to membrane; negative regulation of inflammatory response; negative regulation of monocyte chemotaxis; plasma membrane; response to nutrient levels; spinal cord development IPR000483; IPR002272; IPR001611; IPR003591; IPR000372; Slit homolog 2 protein (Slit-2) (Fragment) Slit2 Rattus norvegicus (Rat) TR40174_c1_g3_i1 P24014 SLIT_DROME 1.00E-12 GO:0035385; GO:0071666; GO:0016199; GO:0005509; GO:0048813; GO:0007502; GO:0035050; GO:0007427; GO:0008347; GO:0008406; GO:0008201; GO:0050929; GO:0046331; GO:0008078; GO:0001764; GO:0003151; GO:0005886; GO:0022409; GO:0005578; GO:2000274; GO:0007432 "Roundabout signaling pathway; Slit-Robo signaling complex; axon midline choice point recognition; calcium ion binding; dendrite morphogenesis; digestive tract mesoderm development; embryonic heart tube development; epithelial cell migration, open tracheal system; glial cell migration; gonad development; heparin binding; induction of negative chemotaxis; lateral inhibition; mesodermal cell migration; neuron migration; outflow tract morphogenesis; plasma membrane; positive regulation of cell-cell adhesion; proteinaceous extracellular matrix; regulation of epithelial cell migration, open tracheal system; salivary gland boundary specification" IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; IPR026906; Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) TR40176_c0_g2_i1 Q54Y96 SMU1_DICDI 1.00E-153 GO:0005737; GO:0005634 cytoplasm; nucleus IPR020472; IPR006594; IPR015943; IPR001680; IPR019775; IPR017986; WD40 repeat-containing protein smu1 smu1 DDB_G0278353 Dictyostelium discoideum (Slime mold) TR40176_c0_g2_i2 Q5M786 WDR5_XENTR 2.00E-27 GO:0071339; GO:0043984; GO:0043981; GO:0043982; GO:0000123; GO:0034968; GO:0035064; GO:0006355; GO:0006351 "MLL1 complex; histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase complex; histone lysine methylation; methylated histone residue binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 5 wdr5 TEgg065j14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40176_c0_g2_i3 Q6NRT3 SMU1_XENLA 0 GO:0005737; GO:0005634 cytoplasm; nucleus IPR006595; IPR020472; IPR006594; IPR015943; IPR001680; IPR019775; IPR017986; WD40 repeat-containing protein SMU1 (Smu-1 suppressor of mec-8 and unc-52 protein homolog) smu1 Xenopus laevis (African clawed frog) TR40176_c0_g2_i5 Q40507 GBB3_TOBAC 2.00E-06 GO:0004871 signal transducer activity IPR020472; IPR001632; IPR016346; IPR015943; IPR001680; IPR019775; IPR017986; Guanine nucleotide-binding protein subunit beta Nicotiana tabacum (Common tobacco) TR40178_c1_g2_i2 O54835 SMAD9_RAT 2.00E-70 GO:0030509; GO:0003677; GO:0001880; GO:0060348; GO:0051216; GO:0071407; GO:0005737; GO:0030902; GO:0046872; GO:0030901; GO:0005634; GO:0045597; GO:0045893; GO:0006468; GO:0001666; GO:0003700; GO:0005667; GO:0006351; GO:0007179; GO:0001657 "BMP signaling pathway; DNA binding; Mullerian duct regression; bone development; cartilage development; cellular response to organic cyclic compound; cytoplasm; hindbrain development; metal ion binding; midbrain development; nucleus; positive regulation of cell differentiation; positive regulation of transcription, DNA-dependent; protein phosphorylation; response to hypoxia; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; ureteric bud development" IPR013790; IPR003619; IPR013019; IPR017855; IPR001132; IPR008984; Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (SMAD family member 9) (SMAD 9) (Smad9) (Smad8) Smad9 Madh8 Madh9 Smad8 Rattus norvegicus (Rat) TR40178_c1_g2_i3 Q56I99 SMAD5_CHICK 2.00E-81 GO:0030509; GO:0000979; GO:0060348; GO:0060048; GO:0051216; GO:0071773; GO:0071407; GO:0005737; GO:0030218; GO:0007281; GO:0046872; GO:0005634; GO:0002051; GO:0045669; GO:1901522; GO:0006468; GO:0003700; GO:0005667; GO:0006351; GO:0007179; GO:0001657 "BMP signaling pathway; RNA polymerase II core promoter sequence-specific DNA binding; bone development; cardiac muscle contraction; cartilage development; cellular response to BMP stimulus; cellular response to organic cyclic compound; cytoplasm; erythrocyte differentiation; germ cell development; metal ion binding; nucleus; osteoblast fate commitment; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; protein phosphorylation; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; ureteric bud development" IPR013790; IPR003619; IPR013019; IPR017855; IPR001132; IPR008984; Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (SMAD family member 5) (SMAD 5) (Smad5) SMAD5 MADH5 Gallus gallus (Chicken) TR40178_c1_g3_i1 Q9I962 SMAD1_COTJA 2.00E-110 GO:0030509; GO:0003677; GO:0005737; GO:0009880; GO:0046872; GO:0005634; GO:0003700; GO:0005667; GO:0006351; GO:0007179 "BMP signaling pathway; DNA binding; cytoplasm; embryonic pattern specification; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway" IPR013790; IPR003619; IPR013019; IPR017855; IPR001132; IPR008984; Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) SMAD1 MADH1 Coturnix coturnix japonica (Japanese quail) (Coturnix japonica) TR40178_c1_g3_i3 P97588 SMAD1_RAT 3.00E-58 GO:0030509; GO:0000165; GO:0000979; GO:0007183; GO:0060348; GO:0060038; GO:0051216; GO:0071773; GO:0071407; GO:0005737; GO:0009880; GO:0007276; GO:0030902; GO:0042592; GO:0006954; GO:0001822; GO:0001710; GO:0046872; GO:0030901; GO:0008285; GO:0010656; GO:0005637; GO:0005634; GO:0002051; GO:0061036; GO:0050775; GO:0045669; GO:1901522; GO:0006468; GO:0042493; GO:0010243; GO:0003700; GO:0005667; GO:0006351; GO:0007179; GO:0001657; GO:0042060 "BMP signaling pathway; MAPK cascade; RNA polymerase II core promoter sequence-specific DNA binding; SMAD protein complex assembly; bone development; cardiac muscle cell proliferation; cartilage development; cellular response to BMP stimulus; cellular response to organic cyclic compound; cytoplasm; embryonic pattern specification; gamete generation; hindbrain development; homeostatic process; inflammatory response; kidney development; mesodermal cell fate commitment; metal ion binding; midbrain development; negative regulation of cell proliferation; negative regulation of muscle cell apoptotic process; nuclear inner membrane; nucleus; osteoblast fate commitment; positive regulation of cartilage development; positive regulation of dendrite morphogenesis; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; protein phosphorylation; response to drug; response to organonitrogen compound; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; ureteric bud development; wound healing" IPR013790; IPR003619; IPR013019; IPR017855; IPR001132; IPR008984; Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (SMAD family member 1) (SMAD 1) (Smad1) Smad1 Mad1 Madh1 Rattus norvegicus (Rat) TR40180_c0_g3_i1 A1A4N1 S29A3_BOVIN 1.00E-84 GO:0016021; GO:0031902; GO:0005765; GO:0005337 integral to membrane; late endosome membrane; lysosomal membrane; nucleoside transmembrane transporter activity IPR002259; Equilibrative nucleoside transporter 3 (Solute carrier family 29 member 3) SLC29A3 ENT3 Bos taurus (Bovine) TR40180_c0_g3_i2 Q14542 S29A2_HUMAN 1.00E-62 GO:0016323; GO:0008283; GO:0005887; GO:0031965; GO:0006139; GO:0005730; GO:0005337; GO:0015858 basolateral plasma membrane; cell proliferation; integral to plasma membrane; nuclear membrane; nucleobase-containing compound metabolic process; nucleolus; nucleoside transmembrane transporter activity; nucleoside transport IPR002259; IPR016196; "Equilibrative nucleoside transporter 2 (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equilibrative NBMPR-insensitive nucleoside transporter) (Hydrophobic nucleolar protein, 36 kDa) (Nucleoside transporter, ei-type) (Solute carrier family 29 member 2)" SLC29A2 DER12 ENT2 HNP36 Homo sapiens (Human) TR40181_c0_g1_i1 Q09228 EGL27_CAEEL 4.00E-29 GO:0016581; GO:0016055; GO:0010171; GO:0007155; GO:0001708; GO:0003682; GO:0009792; GO:0008544; GO:0007163; GO:0031581; GO:0007498; GO:0002119; GO:0018991; GO:0009786; GO:0030334; GO:0006357; GO:0043565; GO:0003700; GO:0045138; GO:0006351; GO:0060290; GO:0008270 "NuRD complex; Wnt receptor signaling pathway; body morphogenesis; cell adhesion; cell fate specification; chromatin binding; embryo development ending in birth or egg hatching; epidermis development; establishment or maintenance of cell polarity; hemidesmosome assembly; mesoderm development; nematode larval development; oviposition; regulation of asymmetric cell division; regulation of cell migration; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; tail tip morphogenesis; transcription, DNA-dependent; transdifferentiation; zinc ion binding" IPR001025; IPR000949; IPR009057; IPR001005; IPR017884; IPR000679; Egg-laying defective protein 27 egl-27 C04A2.3 Caenorhabditis elegans TR40181_c0_g1_i2 Q8K4B0 MTA1_MOUSE 0 GO:0016581; GO:0003682; GO:0005737; GO:0043565; GO:0003700; GO:0008270 NuRD complex; chromatin binding; cytoplasm; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; zinc ion binding IPR001025; IPR000949; IPR009057; IPR001005; IPR017884; IPR000679; Metastasis-associated protein MTA1 Mta1 Mus musculus (Mouse) TR40183_c0_g1_i1 P19133 FRIL_PIG 5.00E-10 GO:0006879; GO:0008199; GO:0008043; GO:0005506; GO:0006826 cellular iron ion homeostasis; ferric iron binding; intracellular ferritin complex; iron ion binding; iron ion transport IPR001519; IPR009040; IPR009078; IPR012347; IPR014034; IPR008331; Ferritin light chain (Ferritin L subunit) (Fragment) FTL Sus scrofa (Pig) TR40183_c0_g1_i4 P85838 FRIH_TREBE 2.00E-26 GO:0006879; GO:0008199; GO:0004322; GO:0006826 cellular iron ion homeostasis; ferric iron binding; ferroxidase activity; iron ion transport IPR001519; IPR009040; IPR009078; IPR012347; IPR014034; IPR008331; "Ferritin, heavy subunit (Ferritin H) (EC 1.16.3.1)" Trematomus bernacchii (Emerald rockcod) (Pagothenia bernacchii) TR40183_c0_g1_i5 P42578 FRIY_LYMST 1.00E-54 GO:0006879; GO:0005576; GO:0008199; GO:0004322; GO:0006826 cellular iron ion homeostasis; extracellular region; ferric iron binding; ferroxidase activity; iron ion transport IPR001519; IPR009040; IPR009078; IPR012347; IPR014034; IPR008331; Yolk ferritin (EC 1.16.3.1) Lymnaea stagnalis (Great pond snail) TR40186_c0_g1_i3 Q9VBG6 FA203_DROME 1.00E-65 IPR016024; IPR007206; IPR007205; FAM203 family protein CG6073 CG6073 Drosophila melanogaster (Fruit fly) TR40186_c0_g1_i4 Q6DGR4 F203A_DANRE 2.00E-79 IPR011989; IPR016024; IPR007206; IPR007205; Protein FAM203A (Brain protein 16) fam203a brp16 zgc:92803 Danio rerio (Zebrafish) (Brachydanio rerio) TR40186_c0_g1_i7 Q6DGR4 F203A_DANRE 9.00E-77 IPR011989; IPR016024; IPR007206; IPR007205; Protein FAM203A (Brain protein 16) fam203a brp16 zgc:92803 Danio rerio (Zebrafish) (Brachydanio rerio) TR40189_c0_g1_i2 O94913 PCF11_HUMAN 4.00E-44 GO:0031124; GO:0006379; GO:0005849; GO:0000398; GO:0006369 "mRNA 3'-end processing; mRNA cleavage; mRNA cleavage factor complex; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription" IPR006569; IPR008942; IPR006903; Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) PCF11 KIAA0824 Homo sapiens (Human) TR40190_c0_g1_i1 P74897 YQA3_THEAQ 2.00E-10 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein in QAH/OAS sulfhydrylase 3'region (USP) Thermus aquaticus TR40190_c0_g1_i2 Q8LGG8 USPAL_ARATH 8.00E-10 GO:0005886; GO:0006950 plasma membrane; response to stress IPR014729; IPR006015; IPR006016; Universal stress protein A-like protein At3g01520 F4P13.7 Arabidopsis thaliana (Mouse-ear cress) TR40190_c0_g1_i5 P74897 YQA3_THEAQ 2.00E-10 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein in QAH/OAS sulfhydrylase 3'region (USP) Thermus aquaticus TR40191_c2_g1_i1 Q9Y2T1 AXIN2_HUMAN 2.00E-17 GO:0005096; GO:0090244; GO:0070016; GO:0008013; GO:0030877; GO:0030282; GO:0005938; GO:0008219; GO:0008283; GO:0034613; GO:0071407; GO:0005813; GO:0003413; GO:0016023; GO:0005881; GO:0009950; GO:0001957; GO:0048255; GO:0043570; GO:2000054; GO:0090090; GO:0035414; GO:0008285; GO:0045668; GO:0005634; GO:0042476; GO:0005886; GO:0010942; GO:0010718; GO:0045860; GO:0001934; GO:0014069; GO:0019901; GO:0070602; GO:0061181; GO:0032423; GO:0004871; GO:0038032 P62714 GTPase activator activity; Wnt receptor signaling pathway involved in somitogenesis; armadillo repeat domain binding; beta-catenin binding; beta-catenin destruction complex; bone mineralization; cell cortex; cell death; cell proliferation; cellular protein localization; cellular response to organic cyclic compound; centrosome; chondrocyte differentiation involved in endochondral bone morphogenesis; cytoplasmic membrane-bounded vesicle; cytoplasmic microtubule; dorsal/ventral axis specification; intramembranous ossification; mRNA stabilization; maintenance of DNA repeat elements; negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of catenin import into nucleus; negative regulation of cell proliferation; negative regulation of osteoblast differentiation; nucleus; odontogenesis; plasma membrane; positive regulation of cell death; positive regulation of epithelial to mesenchymal transition; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; postsynaptic density; protein kinase binding; regulation of centromeric sister chromatid cohesion; regulation of chondrocyte development; regulation of mismatch repair; signal transducer activity; termination of G-protein coupled receptor signaling pathway IPR014936; IPR001158; IPR024066; IPR016137; IPR000342; Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin) AXIN2 Homo sapiens (Human) TR40191_c2_g2_i3 P57095 AXIN2_DANRE 2.00E-20 GO:0005096; GO:0090244; GO:0070016; GO:0008013; GO:0005938; GO:0008219; GO:0071407; GO:0016023; GO:0005881; GO:0009950; GO:0001957; GO:0090090; GO:0045668; GO:0005886; GO:0014069; GO:0019901; GO:0035412; GO:0004871; GO:0038032 GTPase activator activity; Wnt receptor signaling pathway involved in somitogenesis; armadillo repeat domain binding; beta-catenin binding; cell cortex; cell death; cellular response to organic cyclic compound; cytoplasmic membrane-bounded vesicle; cytoplasmic microtubule; dorsal/ventral axis specification; intramembranous ossification; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of osteoblast differentiation; plasma membrane; postsynaptic density; protein kinase binding; regulation of catenin import into nucleus; signal transducer activity; termination of G-protein coupled receptor signaling pathway IPR014936; IPR001158; IPR024066; IPR016137; IPR000342; Axin-2 (Axis inhibition protein 2) axin2 Danio rerio (Zebrafish) (Brachydanio rerio) TR40191_c2_g3_i1 P57094 AXIN1_DANRE 1.00E-31 GO:0005096; GO:0021881; GO:0090244; GO:0007257; GO:0070016; GO:0048320; GO:0008013; GO:0030877; GO:0060823; GO:0005938; GO:0008219; GO:0071407; GO:0016023; GO:0005881; GO:0031122; GO:0007368; GO:0009950; GO:0048048; GO:0060272; GO:0031101; GO:0021797; GO:0055001; GO:0090090; GO:0045599; GO:0030910; GO:0001743; GO:0005886; GO:0046330; GO:0014069; GO:0042803; GO:0019901; GO:0035412; GO:0004871; GO:0038032 GTPase activator activity; Wnt receptor signaling pathway involved in forebrain neuron fate commitment; Wnt receptor signaling pathway involved in somitogenesis; activation of JUN kinase activity; armadillo repeat domain binding; axial mesoderm formation; beta-catenin binding; beta-catenin destruction complex; canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation; cell cortex; cell death; cellular response to organic cyclic compound; cytoplasmic membrane-bounded vesicle; cytoplasmic microtubule; cytoplasmic microtubule organization; determination of left/right symmetry; dorsal/ventral axis specification; embryonic eye morphogenesis; embryonic skeletal joint morphogenesis; fin regeneration; forebrain anterior/posterior pattern specification; muscle cell development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of fat cell differentiation; olfactory placode formation; optic placode formation; plasma membrane; positive regulation of JNK cascade; postsynaptic density; protein homodimerization activity; protein kinase binding; regulation of catenin import into nucleus; signal transducer activity; termination of G-protein coupled receptor signaling pathway IPR014936; IPR001158; IPR024066; IPR016137; IPR000342; Axin-1 (Axis inhibition protein 1) axin1 axin Danio rerio (Zebrafish) (Brachydanio rerio) TR40193_c0_g2_i2 Q9CXC3 CT072_MOUSE 3.00E-28 GO:0043504; GO:0005739; GO:0008297 mitochondrial DNA repair; mitochondrion; single-stranded DNA exodeoxyribonuclease activity IPR026970; Mitochondrial genome maintenance exonuclease 1 (EC 3.1.-.-) Mgme1 Mus musculus (Mouse) TR40194_c0_g1_i2 A4IFD0 KAD5_BOVIN 2.00E-10 GO:0005524; GO:0046034; GO:0004017; GO:0005813; GO:0005737; GO:0004550; GO:0019206; GO:0009142 ATP binding; ATP metabolic process; adenylate kinase activity; centrosome; cytoplasm; nucleoside diphosphate kinase activity; nucleoside kinase activity; nucleoside triphosphate biosynthetic process IPR000850; IPR006267; IPR003117; IPR027417; Adenylate kinase isoenzyme 5 (AK 5) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 5) Ak5 Bos taurus (Bovine) TR40197_c0_g2_i2 O08848 RO60_MOUSE 1.00E-45 GO:0003723; GO:0060271; GO:0005737; GO:0046872; GO:0030529 RNA binding; cilium morphogenesis; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) Trove2 Ssa2 Mus musculus (Mouse) TR40197_c0_g2_i3 P42700 RO60_XENLA 2.00E-46 GO:0003723; GO:0030030; GO:0005737; GO:0046872; GO:0030529 RNA binding; cell projection organization; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) trove2 Xenopus laevis (African clawed frog) TR40197_c0_g2_i5 P42700 RO60_XENLA 1.00E-46 GO:0003723; GO:0030030; GO:0005737; GO:0046872; GO:0030529 RNA binding; cell projection organization; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) trove2 Xenopus laevis (African clawed frog) TR40197_c0_g2_i6 O08848 RO60_MOUSE 1.00E-44 GO:0003723; GO:0060271; GO:0005737; GO:0046872; GO:0030529 RNA binding; cilium morphogenesis; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) Trove2 Ssa2 Mus musculus (Mouse) TR40197_c0_g3_i3 Q9RUW8 RO60_DEIRA 8.00E-25 GO:0003723; GO:0005737; GO:0046872; GO:0030529 RNA binding; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein homolog (Ro sixty-related protein) rsr DR_1262 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) TR40198_c3_g1_i1 Q9JLB5 ACH10_RAT 3.00E-23 GO:0004889; GO:0030424; GO:0005262; GO:0030054; GO:0007204; GO:0016021; GO:0043204; GO:0045211; GO:0007271 "acetylcholine-activated cation-selective channel activity; axon; calcium channel activity; cell junction; elevation of cytosolic calcium ion concentration; integral to membrane; perikaryon; postsynaptic membrane; synaptic transmission, cholinergic" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) Chrna10 Rattus norvegicus (Rat) TR40198_c3_g1_i10 P48180 ACH1_CAEEL 6.00E-33 GO:0004889; GO:0030054; GO:0042995; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; cell projection; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha-type acr-16 acr-16 Ce21 F25G6.3 Caenorhabditis elegans TR40198_c3_g1_i11 A8WQK3 ACH1_CAEBR 4.00E-35 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha-type acr-16 acr-16 CBG01491 Caenorhabditis briggsae TR40198_c3_g1_i3 P22770 ACHA7_CHICK 2.00E-28 GO:0042166; GO:0015464; GO:0004889; GO:0005892; GO:0000187; GO:0001540; GO:0006816; GO:0030054; GO:0006874; GO:0017081; GO:0050890; GO:0032720; GO:0045766; GO:0008284; GO:0045211; GO:0042803; GO:0001666; GO:0035094; GO:0015643 acetylcholine binding; acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; activation of MAPK activity; beta-amyloid binding; calcium ion transport; cell junction; cellular calcium ion homeostasis; chloride channel regulator activity; cognition; negative regulation of tumor necrosis factor production; positive regulation of angiogenesis; positive regulation of cell proliferation; postsynaptic membrane; protein homodimerization activity; response to hypoxia; response to nicotine; toxic substance binding IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 Gallus gallus (Chicken) TR40198_c3_g1_i5 P91766 ACH1_MANSE 6.00E-24 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha-like (MARA1) ARA1 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) TR40198_c3_g1_i7 P02714 ACHG_TORCA 7.00E-13 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit gamma CHRNG Torpedo californica (Pacific electric ray) TR40198_c3_g1_i8 A8WQK3 ACH1_CAEBR 1.00E-34 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha-type acr-16 acr-16 CBG01491 Caenorhabditis briggsae TR40198_c3_g1_i9 P02712 ACHB_TORCA 2.00E-11 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit beta CHRNB1 Torpedo californica (Pacific electric ray) TR40198_c5_g1_i1 A2AX52 CO6A4_MOUSE 3.00E-12 GO:0007155; GO:0005581; GO:0005576; GO:0043234; GO:0070208 cell adhesion; collagen; extracellular region; protein complex; protein heterotrimerization IPR008160; IPR002035; Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) TR40201_c1_g1_i2 O62830 PPM1B_BOVIN 2.00E-160 GO:0006499; GO:0005829; GO:0000287; GO:0030145; GO:0016020; GO:0043124; GO:0042347; GO:0050687; GO:0032688; GO:0035970; GO:0006470; GO:0004722 N-terminal protein myristoylation; cytosol; magnesium ion binding; manganese ion binding; membrane; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of NF-kappaB import into nucleus; negative regulation of defense response to virus; negative regulation of interferon-beta production; peptidyl-threonine dephosphorylation; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR012911; IPR000222; IPR015655; Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta) PPM1B Bos taurus (Bovine) TR40205_c0_g1_i1 Q5F3X4 U5S1_CHICK 0 GO:0005525; GO:0006184; GO:0003924; GO:0008380; GO:0006397; GO:0005681 GTP binding; GTP catabolic process; GTPase activity; RNA splicing; mRNA processing; spliceosomal complex IPR000795; IPR009022; IPR000640; IPR027417; IPR020568; IPR014721; IPR005225; IPR009000; IPR005517; IPR004161; "116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain protein 2) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)" EFTUD2 SNRP116 RCJMB04_4m11 Gallus gallus (Chicken) TR40205_c0_g1_i2 Q23716 EF2_CRYPV 5.00E-97 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; translation elongation factor activity IPR000795; IPR009022; IPR000640; IPR027417; IPR020568; IPR014721; IPR005225; IPR009000; IPR005517; IPR004161; Elongation factor 2 (EF-2) Cryptosporidium parvum TR40205_c0_g2_i1 Q5F3X4 U5S1_CHICK 0 GO:0005525; GO:0006184; GO:0003924; GO:0008380; GO:0006397; GO:0005681 GTP binding; GTP catabolic process; GTPase activity; RNA splicing; mRNA processing; spliceosomal complex IPR000795; IPR009022; IPR000640; IPR027417; IPR020568; IPR014721; IPR005225; IPR009000; IPR005517; IPR004161; "116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain protein 2) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)" EFTUD2 SNRP116 RCJMB04_4m11 Gallus gallus (Chicken) TR40206_c1_g1_i1 Q5RIC0 ELP3_DANRE 0 GO:0007409; GO:0005737; GO:0016573; GO:0004402; GO:0051536; GO:0046872; GO:0008607; GO:0006357; GO:0008023; GO:0006351 "axonogenesis; cytoplasm; histone acetylation; histone acetyltransferase activity; iron-sulfur cluster binding; metal ion binding; phosphorylase kinase regulator activity; regulation of transcription from RNA polymerase II promoter; transcription elongation factor complex; transcription, DNA-dependent" IPR016181; IPR006638; IPR000182; IPR005910; IPR007197; IPR023404; Elongator complex protein 3 (EC 2.3.1.48) elp3 si:ch211-63o20.8 zgc:113140 Danio rerio (Zebrafish) (Brachydanio rerio) TR40207_c1_g1_i1 Q6PBA8 MNS1_DANRE 3.00E-98 GO:0007126; GO:0005634 meiosis; nucleus IPR026504; Meiosis-specific nuclear structural protein 1 mns1 zgc:65845 Danio rerio (Zebrafish) (Brachydanio rerio) TR40208_c4_g2_i3 Q4H3N8 ENY2_CIOIN 1.00E-36 GO:0000124; GO:0016568; GO:0051028; GO:0005643; GO:0045893; GO:0015031; GO:0003713; GO:0006351 "SAGA complex; chromatin modification; mRNA transport; nuclear pore; positive regulation of transcription, DNA-dependent; protein transport; transcription coactivator activity; transcription, DNA-dependent" IPR018783; Transcription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog) ENY2 Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) TR40208_c4_g2_i5 Q9JIX0 ENY2_MOUSE 7.00E-38 GO:0000124; GO:0016578; GO:0030374; GO:0051028; GO:0005643; GO:0045893; GO:0015031; GO:0006351 "SAGA complex; histone deubiquitination; ligand-dependent nuclear receptor transcription coactivator activity; mRNA transport; nuclear pore; positive regulation of transcription, DNA-dependent; protein transport; transcription, DNA-dependent" IPR018783; Transcription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog) Eny2 Mus musculus (Mouse) TR40209_c0_g1_i1 Q08628 TBA_BLEJA 1.00E-15 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization IPR008280; IPR000217; IPR023123; Tubulin alpha chain (Fragment) Blepharisma japonicum TR40209_c3_g1_i1 P33626 TBA4_MAIZE 2.00E-24 GO:0005525; GO:0005737; GO:0005874; GO:0007017 GTP binding; cytoplasm; microtubule; microtubule-based process IPR000217; IPR003008; Tubulin alpha-4 chain (Alpha-4-tubulin) (Fragments) TUBA4 TUA4 Zea mays (Maize) TR40209_c8_g1_i1 P06603 TBA1_DROME 2.00E-134 GO:0005525; GO:0003924; GO:0019730; GO:0000235; GO:0005813; GO:0007094; GO:0007052; GO:0051258; GO:0005200 GTP binding; GTPase activity; antimicrobial humoral response; astral microtubule; centrosome; mitotic spindle assembly checkpoint; mitotic spindle organization; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-1 chain alphaTub84B tubA84B CG1913 Drosophila melanogaster (Fruit fly) TR40209_c8_g1_i2 A0AAL4 TBA_DICPU 4.00E-78 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha chain (Alpha-tubulin) (Fragment) tuba Dictyostelium purpureum (Slime mold) TR40209_c8_g1_i4 P40633 TBG_COCHE 1.00E-18 GO:0005525; GO:0003924; GO:0031122; GO:0000930; GO:0005874; GO:0007020; GO:0051258; GO:0005816 GTP binding; GTPase activity; cytoplasmic microtubule organization; gamma-tubulin complex; microtubule; microtubule nucleation; protein polymerization; spindle pole body IPR002454; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin gamma chain (Gamma-tubulin) TUB4 COCHEDRAFT_1179534 Cochliobolus heterostrophus (strain C5 / ATCC 48332 / race O) (Southern corn leaf blight fungus) (Bipolaris maydis) TR40209_c8_g1_i5 Q9H853 TBA4B_HUMAN 4.00E-83 GO:0005525; GO:0005737; GO:0005874; GO:0007017; GO:0005200 GTP binding; cytoplasm; microtubule; microtubule-based process; structural constituent of cytoskeleton IPR002452; IPR000217; IPR003008; Putative tubulin-like protein alpha-4B (Alpha-tubulin 4B) TUBA4B TUBA4 Homo sapiens (Human) TR40209_c8_g1_i6 P07304 TBA1_STYLE 2.00E-127 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-1 chain Stylonychia lemnae TR40209_c8_g2_i1 P02553 TBA_LYTPI 5.00E-78 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; Tubulin alpha chain (Fragment) Lytechinus pictus (Painted sea urchin) TR40209_c8_g2_i2 Q07972 TBAA_PNECA 2.00E-98 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR003008; Tubulin alpha chain (Fragment) TUB-A Pneumocystis carinii TR40209_c8_g2_i3 P09645 TBA8_CHICK 5.00E-118 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-8 chain (Fragment) Gallus gallus (Chicken) TR40209_c8_g2_i4 P86234 TBA3_MESAU 8.00E-62 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization IPR008280; IPR000217; IPR018316; IPR003008; Tubulin alpha-3 chain (Fragments) Mesocricetus auratus (Golden hamster) TR40209_c8_g2_i5 P02553 TBA_LYTPI 3.00E-99 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; Tubulin alpha chain (Fragment) Lytechinus pictus (Painted sea urchin) TR40209_c8_g2_i6 P02552 TBA1_CHICK 6.00E-155 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-1 chain (Fragment) Gallus gallus (Chicken) TR40209_c8_g3_i1 P33626 TBA4_MAIZE 1.00E-16 GO:0005525; GO:0005737; GO:0005874; GO:0007017 GTP binding; cytoplasm; microtubule; microtubule-based process IPR000217; IPR003008; Tubulin alpha-4 chain (Alpha-4-tubulin) (Fragments) TUBA4 TUA4 Zea mays (Maize) TR40210_c10_g1_i1 P25152 BSAP_BACSU 4.00E-06 GO:0004177; GO:0005576; GO:0046872; GO:0008237; GO:0006508 aminopeptidase activity; extracellular region; metal ion binding; metallopeptidase activity; proteolysis IPR007484; IPR003137; Aminopeptidase YwaD (Arginyl aminopeptidase) (EC 3.4.11.6) (BSAP) (Leucyl aminopeptidase) (EC 3.4.11.10) ywaD BSU38470 ipa-8r Bacillus subtilis (strain 168) TR40210_c10_g1_i7 P25152 BSAP_BACSU 4.00E-06 GO:0004177; GO:0005576; GO:0046872; GO:0008237; GO:0006508 aminopeptidase activity; extracellular region; metal ion binding; metallopeptidase activity; proteolysis IPR007484; IPR003137; Aminopeptidase YwaD (Arginyl aminopeptidase) (EC 3.4.11.6) (BSAP) (Leucyl aminopeptidase) (EC 3.4.11.10) ywaD BSU38470 ipa-8r Bacillus subtilis (strain 168) TR40212_c3_g1_i1 Q86U86 PB1_HUMAN 2.00E-64 GO:0003677; GO:0003682; GO:0006338; GO:0007507; GO:0000776; GO:0007067; GO:0008285; GO:0000228; GO:0001890; GO:0006355; GO:0006351 Q68CP9; P51532 "DNA binding; chromatin binding; chromatin remodeling; heart development; kinetochore; mitosis; negative regulation of cell proliferation; nuclear chromosome; placenta development; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001025; IPR001487; IPR018359; IPR009071; Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) PBRM1 BAF180 PB1 Homo sapiens (Human) TR40212_c3_g1_i3 Q90941 PB1_CHICK 5.00E-61 GO:0003677; GO:0016568; GO:0005634; GO:0006355; GO:0006351 "DNA binding; chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001025; IPR001487; IPR018359; IPR009071; Protein polybromo-1 PBRM1 PB1 Gallus gallus (Chicken) TR40212_c4_g2_i2 P87053 POF1_SCHPO 1.00E-12 GO:0019005; GO:0071276; GO:0005634; GO:0042787; GO:0007346 Q9Y709 SCF ubiquitin ligase complex; cellular response to cadmium ion; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of mitotic cell cycle IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein pof1 (Skp1-binding protein 1) pof1 sbp1 SPAC57A10.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40212_c5_g1_i10 Q86U86 PB1_HUMAN 2.00E-123 GO:0003677; GO:0003682; GO:0006338; GO:0007507; GO:0000776; GO:0007067; GO:0008285; GO:0000228; GO:0001890; GO:0006355; GO:0006351 Q68CP9; P51532 "DNA binding; chromatin binding; chromatin remodeling; heart development; kinetochore; mitosis; negative regulation of cell proliferation; nuclear chromosome; placenta development; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001025; IPR001487; IPR018359; IPR009071; Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) PBRM1 BAF180 PB1 Homo sapiens (Human) TR40212_c5_g1_i2 Q86U86 PB1_HUMAN 6.00E-126 GO:0003677; GO:0003682; GO:0006338; GO:0007507; GO:0000776; GO:0007067; GO:0008285; GO:0000228; GO:0001890; GO:0006355; GO:0006351 Q68CP9; P51532 "DNA binding; chromatin binding; chromatin remodeling; heart development; kinetochore; mitosis; negative regulation of cell proliferation; nuclear chromosome; placenta development; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001025; IPR001487; IPR018359; IPR009071; Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) PBRM1 BAF180 PB1 Homo sapiens (Human) TR40212_c5_g1_i3 Q8BSQ9 PB1_MOUSE 2.00E-126 GO:0003677; GO:0001974; GO:0060948; GO:0003682; GO:0016568; GO:0003349; GO:0003007; GO:0000776; GO:0008285; GO:0005634; GO:0001890; GO:0045893; GO:0006351; GO:0060979 "DNA binding; blood vessel remodeling; cardiac vascular smooth muscle cell development; chromatin binding; chromatin modification; epicardium-derived cardiac endothelial cell differentiation; heart morphogenesis; kinetochore; negative regulation of cell proliferation; nucleus; placenta development; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; vasculogenesis involved in coronary vascular morphogenesis" IPR001025; IPR001487; IPR018359; IPR009071; Protein polybromo-1 (BRG1-associated factor 180) (BAF180) Pbrm1 Baf180 Pb1 Mus musculus (Mouse) TR40212_c5_g1_i5 Q86U86 PB1_HUMAN 5.00E-124 GO:0003677; GO:0003682; GO:0006338; GO:0007507; GO:0000776; GO:0007067; GO:0008285; GO:0000228; GO:0001890; GO:0006355; GO:0006351 Q68CP9; P51532 "DNA binding; chromatin binding; chromatin remodeling; heart development; kinetochore; mitosis; negative regulation of cell proliferation; nuclear chromosome; placenta development; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001025; IPR001487; IPR018359; IPR009071; Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) PBRM1 BAF180 PB1 Homo sapiens (Human) TR40212_c5_g1_i7 O44757 LIN59_CAEEL 1.00E-10 GO:0003677; GO:0001715; GO:0009792; GO:0048566; GO:0034968; GO:0018024; GO:0040011; GO:0002119; GO:0005634; GO:0018991; GO:0045944; GO:0040014; GO:0045138; GO:0006351; GO:0008270 "DNA binding; ectodermal cell fate specification; embryo development ending in birth or egg hatching; embryonic digestive tract development; histone lysine methylation; histone-lysine N-methyltransferase activity; locomotion; nematode larval development; nucleus; oviposition; positive regulation of transcription from RNA polymerase II promoter; regulation of multicellular organism growth; tail tip morphogenesis; transcription, DNA-dependent; zinc ion binding" IPR006560; IPR001025; IPR001214; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Probable histone-lysine N-methyltransferase lin-59 (EC 2.1.1.43) (Abnormal cell lineage protein 59) lin-59 T12F5.4 Caenorhabditis elegans TR40212_c5_g1_i8 O74964 RSC1_SCHPO 6.00E-19 GO:0003677; GO:0016586; GO:0006338; GO:0000122; GO:0000790; GO:0045944; GO:1900388; GO:0006351 "DNA binding; RSC complex; chromatin remodeling; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; positive regulation of transcription from RNA polymerase II promoter; regulation of vesicle-mediated transport by regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR001025; IPR001487; IPR018359; Chromatin structure-remodeling complex subunit rsc1 (RSC complex subunit rsc1) (Remodel the structure of chromatin complex subunit 1) rsc1 SPBC4B4.03 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40212_c5_g1_i9 O44757 LIN59_CAEEL 9.00E-11 GO:0003677; GO:0001715; GO:0009792; GO:0048566; GO:0034968; GO:0018024; GO:0040011; GO:0002119; GO:0005634; GO:0018991; GO:0045944; GO:0040014; GO:0045138; GO:0006351; GO:0008270 "DNA binding; ectodermal cell fate specification; embryo development ending in birth or egg hatching; embryonic digestive tract development; histone lysine methylation; histone-lysine N-methyltransferase activity; locomotion; nematode larval development; nucleus; oviposition; positive regulation of transcription from RNA polymerase II promoter; regulation of multicellular organism growth; tail tip morphogenesis; transcription, DNA-dependent; zinc ion binding" IPR006560; IPR001025; IPR001214; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Probable histone-lysine N-methyltransferase lin-59 (EC 2.1.1.43) (Abnormal cell lineage protein 59) lin-59 T12F5.4 Caenorhabditis elegans TR40212_c5_g2_i1 Q09948 RSC4_SCHPO 1.00E-32 GO:0016586; GO:0006338; GO:0005829; GO:0000122; GO:0000790; GO:0045944; GO:0006351 "RSC complex; chromatin remodeling; cytosol; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR001487; Chromatin structure-remodeling complex subunit rsc4 (Bromodomain-containing protein brd1) (RSC complex subunit rsc4) rsc4 brd1 SPBC1734.15 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40213_c1_g2_i1 Q8IZD2 MLL5_HUMAN 1.00E-36 GO:0006306; GO:0070688; GO:0007050; GO:0071300; GO:0030218; GO:0042800; GO:0042119; GO:0002446; GO:0016607; GO:0030854; GO:0045893; GO:0048384; GO:0003713; GO:0006351; GO:0008270 O15294; P10276; P04637 "DNA methylation; MLL5-L complex; cell cycle arrest; cellular response to retinoic acid; erythrocyte differentiation; histone methyltransferase activity (H3-K4 specific); neutrophil activation; neutrophil mediated immunity; nuclear speck; positive regulation of granulocyte differentiation; positive regulation of transcription, DNA-dependent; retinoic acid receptor signaling pathway; transcription coactivator activity; transcription, DNA-dependent; zinc ion binding" IPR001214; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Histone-lysine N-methyltransferase 2E (Lysine N-methyltransferase 2E) (EC 2.1.1.43) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) KMT2E MLL5 Homo sapiens (Human) TR40214_c1_g1_i1 Q96Q07 BTBD9_HUMAN 2.00E-19 GO:0008344; GO:0007155; GO:0042748; GO:0007616; GO:0060586; GO:1900242; GO:0050951; GO:0042428 "adult locomotory behavior; cell adhesion; circadian sleep/wake cycle, non-REM sleep; long-term memory; multicellular organismal iron ion homeostasis; regulation of synaptic vesicle endocytosis; sensory perception of temperature stimulus; serotonin metabolic process" IPR011705; IPR000210; IPR011333; IPR013069; IPR000421; IPR008979; BTB/POZ domain-containing protein 9 BTBD9 KIAA1880 Homo sapiens (Human) TR40214_c1_g3_i1 Q96Q07 BTBD9_HUMAN 4.00E-144 GO:0008344; GO:0007155; GO:0042748; GO:0007616; GO:0060586; GO:1900242; GO:0050951; GO:0042428 "adult locomotory behavior; cell adhesion; circadian sleep/wake cycle, non-REM sleep; long-term memory; multicellular organismal iron ion homeostasis; regulation of synaptic vesicle endocytosis; sensory perception of temperature stimulus; serotonin metabolic process" IPR011705; IPR000210; IPR011333; IPR013069; IPR000421; IPR008979; BTB/POZ domain-containing protein 9 BTBD9 KIAA1880 Homo sapiens (Human) TR40214_c1_g4_i1 Q53HC5 KLH26_HUMAN 2.00E-18 IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 26 KLHL26 Homo sapiens (Human) TR40215_c1_g1_i1 Q99758 ABCA3_HUMAN 0 GO:0005524; GO:0042626; GO:0097208; GO:0097233; GO:0016021; GO:0005886; GO:0042493 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; alveolar lamellar body; alveolar lamellar body membrane; integral to membrane; plasma membrane; response to drug" IPR003593; IPR026082; IPR003439; IPR017871; IPR026969; IPR027417; ATP-binding cassette sub-family A member 3 (ABC-C transporter) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) ABCA3 ABC3 Homo sapiens (Human) TR40215_c1_g1_i4 P41234 ABCA2_MOUSE 6.00E-132 GO:0005524; GO:0016887; GO:0042632; GO:0016023; GO:0005768; GO:0010008; GO:0016021; GO:0005765; GO:0005815; GO:0032383; GO:0006357; GO:0048545; GO:0006810 ATP binding; ATPase activity; cholesterol homeostasis; cytoplasmic membrane-bounded vesicle; endosome; endosome membrane; integral to membrane; lysosomal membrane; microtubule organizing center; regulation of intracellular cholesterol transport; regulation of transcription from RNA polymerase II promoter; response to steroid hormone stimulus; transport IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 2 (ATP-binding cassette transporter 2) (ATP-binding cassette 2) Abca2 Abc2 Mus musculus (Mouse) TR40215_c1_g1_i5 Q99758 ABCA3_HUMAN 0 GO:0005524; GO:0042626; GO:0097208; GO:0097233; GO:0016021; GO:0005886; GO:0042493 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; alveolar lamellar body; alveolar lamellar body membrane; integral to membrane; plasma membrane; response to drug" IPR003593; IPR026082; IPR003439; IPR017871; IPR026969; IPR027417; ATP-binding cassette sub-family A member 3 (ABC-C transporter) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) ABCA3 ABC3 Homo sapiens (Human) TR40215_c1_g1_i7 Q99758 ABCA3_HUMAN 0 GO:0005524; GO:0042626; GO:0097208; GO:0097233; GO:0016021; GO:0005886; GO:0042493 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; alveolar lamellar body; alveolar lamellar body membrane; integral to membrane; plasma membrane; response to drug" IPR003593; IPR026082; IPR003439; IPR017871; IPR026969; IPR027417; ATP-binding cassette sub-family A member 3 (ABC-C transporter) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) ABCA3 ABC3 Homo sapiens (Human) TR40215_c1_g1_i9 Q63TX3 NODI_BURPS 2.00E-46 GO:0005524; GO:0006200; GO:0016887; GO:0009877; GO:0005886; GO:0005215 ATP binding; ATP catabolic process; ATPase activity; nodulation; plasma membrane; transporter activity IPR003593; IPR003439; IPR017871; IPR015851; IPR005978; IPR027417; Nod factor export ATP-binding protein I (EC 3.6.3.-) (Nodulation ATP-binding protein I) nodI BPSL1844 Burkholderia pseudomallei (strain K96243) TR40217_c0_g1_i7 Q6DGL2 KBRS2_DANRE 6.00E-59 GO:0005525; GO:0003924; GO:0005737; GO:0016020; GO:0007264 GTP binding; GTPase activity; cytoplasm; membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; NF-kappa-B inhibitor-interacting Ras-like protein 2 (I-kappa-B-interacting Ras-like protein 2) (Kappa B-Ras protein 2) (KappaB-Ras2) nkiras2 zgc:92870 Danio rerio (Zebrafish) (Brachydanio rerio) TR40218_c0_g1_i1 Q9UHR5 S30BP_HUMAN 3.00E-43 GO:0006915; GO:0045111; GO:0005634; GO:0010942; GO:0006355; GO:0006351 Q9UHX1 "apoptotic process; intermediate filament cytoskeleton; nucleus; positive regulation of cell death; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR012479; SAP30-binding protein (Transcriptional regulator protein HCNGP) SAP30BP HCNGP HTRG HTRP Homo sapiens (Human) TR40219_c1_g1_i1 Q17FR9 SRRT_AEDAE 1.00E-139 GO:0005654; GO:0031053 nucleoplasm; primary miRNA processing IPR007042; IPR021933; Serrate RNA effector molecule homolog (Arsenite-resistance protein 2 homolog) Ars2 AAEL003287 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR40219_c1_g1_i3 Q5TUF1 SRRT_ANOGA 7.00E-138 GO:0005654; GO:0031053 nucleoplasm; primary miRNA processing IPR007042; IPR021933; Serrate RNA effector molecule homolog (Arsenite-resistance protein 2 homolog) Ars2 AGAP010382 Anopheles gambiae (African malaria mosquito) TR40219_c1_g2_i5 Q9ZVD0 SRRT_ARATH 9.00E-10 GO:0003677; GO:0008380; GO:0009507; GO:0016568; GO:0005829; GO:0006397; GO:0046872; GO:0010445; GO:0016607; GO:0005730; GO:0031053; GO:0010267; GO:2000011; GO:0048509; GO:0003700; GO:0048367 Q5YDB6; O04492 DNA binding; RNA splicing; chloroplast; chromatin modification; cytosol; mRNA processing; metal ion binding; nuclear dicing body; nuclear speck; nucleolus; primary miRNA processing; production of ta-siRNAs involved in RNA interference; regulation of adaxial/abaxial pattern formation; regulation of meristem development; sequence-specific DNA binding transcription factor activity; shoot system development IPR007042; IPR021933; IPR007087; IPR015880; Serrate RNA effector molecule SE At2g27100 T20P8.15 Arabidopsis thaliana (Mouse-ear cress) TR40220_c0_g2_i2 Q6DEB4 AR19A_XENLA 3.00E-21 GO:0000086; GO:0051301; GO:0005737; GO:0007067; GO:0005654; GO:0019212; GO:0051721; GO:0004864; GO:0008601 G2/M transition of mitotic cell cycle; cell division; cytoplasm; mitosis; nucleoplasm; phosphatase inhibitor activity; protein phosphatase 2A binding; protein phosphatase inhibitor activity; protein phosphatase type 2A regulator activity IPR006760; cAMP-regulated phosphoprotein 19-A (ARPP-19-A) arpp19-a arpp19 Xenopus laevis (African clawed frog) TR40221_c7_g2_i6 A5PJA1 KAD6_BOVIN 6.00E-82 GO:0005524; GO:0015030; GO:0003677; GO:0004017 ATP binding; Cajal body; DNA binding; adenylate kinase activity IPR027417; IPR000623; Adenylate kinase isoenzyme 6 (AK6) (EC 2.7.4.3) (Coilin-interacting nuclear ATPase protein) (Dual activity adenylate kinase/ATPase) (AK/ATPase) TAF9 AK6 CINAP Bos taurus (Bovine) TR40222_c1_g2_i1 Q6ZQH8 NU188_MOUSE 6.00E-57 GO:0051028; GO:0005643; GO:0015031 mRNA transport; nuclear pore; protein transport IPR016024; IPR018864; Nucleoporin NUP188 homolog Nup188 Kiaa0169 Mus musculus (Mouse) TR40222_c1_g3_i1 Q5SRE5 NU188_HUMAN 5.00E-122 GO:0005975; GO:0019221; GO:0015758; GO:0051028; GO:0007077; GO:0005635; GO:0005643; GO:0015031; GO:0010827; GO:0044281; GO:0055085; GO:0016032 carbohydrate metabolic process; cytokine-mediated signaling pathway; glucose transport; mRNA transport; mitotic nuclear envelope disassembly; nuclear envelope; nuclear pore; protein transport; regulation of glucose transport; small molecule metabolic process; transmembrane transport; viral process IPR016024; IPR018864; Nucleoporin NUP188 homolog (hNup188) NUP188 KIAA0169 Homo sapiens (Human) TR40223_c0_g1_i1 Q969R2 OSBP2_HUMAN 2.00E-167 GO:0015485; GO:0006869; GO:0016020; GO:0005543 cholesterol binding; lipid transport; membrane; phospholipid binding IPR000648; IPR018494; IPR011993; IPR001849; Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (ORP-4) (OSBP-related protein 4) OSBP2 KIAA1664 ORP4 OSBPL4 Homo sapiens (Human) TR40223_c0_g1_i2 Q969R2 OSBP2_HUMAN 2.00E-163 GO:0015485; GO:0006869; GO:0016020; GO:0005543 cholesterol binding; lipid transport; membrane; phospholipid binding IPR000648; IPR018494; IPR011993; IPR001849; Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (ORP-4) (OSBP-related protein 4) OSBP2 KIAA1664 ORP4 OSBPL4 Homo sapiens (Human) TR40223_c0_g1_i3 Q3B7Z2 OSBP1_MOUSE 2.00E-155 GO:0000139; GO:0006869; GO:0005543 Golgi membrane; lipid transport; phospholipid binding IPR000648; IPR018494; IPR011993; IPR001849; Oxysterol-binding protein 1 Osbp Kiaa4220 Mus musculus (Mouse) TR40224_c0_g1_i1 Q1RMT1 ERCC3_BOVIN 0 GO:0043138; GO:0005524; GO:0004003; GO:0016887; GO:0003677; GO:0006265; GO:0008353; GO:0009650; GO:0006915; GO:0000075; GO:0035315; GO:0005675; GO:0000717; GO:0033683; GO:0045944; GO:0008022; GO:0047485; GO:0008104; GO:0006468; GO:1901990; GO:0009411; GO:0006979; GO:0006366; GO:0006283 "3'-5' DNA helicase activity; ATP binding; ATP-dependent DNA helicase activity; ATPase activity; DNA binding; DNA topological change; RNA polymerase II carboxy-terminal domain kinase activity; UV protection; apoptotic process; cell cycle checkpoint; hair cell differentiation; holo TFIIH complex; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision; positive regulation of transcription from RNA polymerase II promoter; protein C-terminus binding; protein N-terminus binding; protein localization; protein phosphorylation; regulation of mitotic cell cycle phase transition; response to UV; response to oxidative stress; transcription from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair" IPR006935; IPR014001; IPR001650; IPR001161; IPR027417; TFIIH basal transcription factor complex helicase XPB subunit (EC 3.6.4.12) (DNA excision repair protein ERCC-3) ERCC3 Bos taurus (Bovine) TR40224_c0_g2_i1 Q4R4E0 NDUB5_MACFA 2.00E-20 GO:0016021; GO:0005743; GO:0055114; GO:0070469 integral to membrane; mitochondrial inner membrane; oxidation-reduction process; respiratory chain IPR019173; "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (CI-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit)" NDUFB5 QtsA-10659 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR40224_c0_g4_i1 Q4R4E0 NDUB5_MACFA 1.00E-10 GO:0016021; GO:0005743; GO:0055114; GO:0070469 integral to membrane; mitochondrial inner membrane; oxidation-reduction process; respiratory chain IPR019173; "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (CI-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit)" NDUFB5 QtsA-10659 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR40225_c1_g1_i1 Q5BKU9 OXLD1_HUMAN 7.00E-14 GO:0005739 mitochondrion IPR019180; Oxidoreductase-like domain-containing protein 1 OXLD1 C17orf90 Homo sapiens (Human) TR40230_c0_g1_i3 Q32LM2 SGTA_BOVIN 2.00E-09 GO:0005737 cytoplasm IPR013026; IPR011990; IPR001440; IPR019734; Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) SGTA Bos taurus (Bovine) TR40230_c0_g3_i1 O70593 SGTA_RAT 3.00E-39 GO:0005737 cytoplasm IPR013026; IPR011990; IPR001440; IPR019734; Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 1) Sgta Sgt Sgt1 Stg Rattus norvegicus (Rat) TR40231_c0_g1_i2 Q71U00 SKP1_XENLA 9.00E-70 GO:0019005; GO:0016567; GO:0006511 SCF ubiquitin ligase complex; protein ubiquitination; ubiquitin-dependent protein catabolic process IPR011333; IPR016897; IPR001232; IPR016072; IPR016073; Protein modification; protein ubiquitination. S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1) skp1 skp1a Xenopus laevis (African clawed frog) TR40231_c0_g1_i5 Q8NK13 SKP1_NEUCR 1.00E-49 GO:0016567; GO:0006511 protein ubiquitination; ubiquitin-dependent protein catabolic process IPR011333; IPR016897; IPR001232; IPR016072; IPR016073; Protein modification; protein ubiquitination. E3 ubiquitin ligase complex SCF subunit scon-3 (Sulfur controller-3) (Sulfur metabolite repression control scon-3) scon-3 NCU08991 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR40231_c0_g1_i7 Q71U00 SKP1_XENLA 2.00E-69 GO:0019005; GO:0016567; GO:0006511 SCF ubiquitin ligase complex; protein ubiquitination; ubiquitin-dependent protein catabolic process IPR011333; IPR016897; IPR001232; IPR016072; IPR016073; Protein modification; protein ubiquitination. S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1) skp1 skp1a Xenopus laevis (African clawed frog) TR40232_c0_g1_i1 Q03070 CHIO_RAT 7.00E-14 GO:0030675; GO:0001675; GO:0005622; GO:0035556; GO:0016020; GO:0046872; GO:0001565 Rac GTPase activator activity; acrosome assembly; intracellular; intracellular signal transduction; membrane; metal ion binding; phorbol ester receptor activity IPR020454; IPR002219; IPR008936; IPR000198; Beta-chimaerin (Beta-chimerin) (Rho GTPase-activating protein 3) Chn2 Arhgap3 Bch Rattus norvegicus (Rat) TR40232_c0_g1_i3 Q15139 KPCD1_HUMAN 0 GO:0005524; GO:0005794; GO:0007030; GO:0048193; GO:0001525; GO:0006915; GO:0005938; GO:0008283; GO:0005911; GO:0034599; GO:0005829; GO:0006954; GO:0045087; GO:0005887; GO:0007229; GO:0007243; GO:0046872; GO:0060548; GO:0045806; GO:0005634; GO:0018105; GO:0005543; GO:0032793; GO:0043123; GO:0051092; GO:0045766; GO:0043536; GO:0038033; GO:0001938; GO:1901727; GO:0010976; GO:0045669; GO:0033138; GO:0045944; GO:0046777; GO:0004697; GO:0004674; GO:2001044; GO:0010837; GO:0044281; GO:0030148; GO:0005802 Itself; Q07021; P12830; P08238; O15264; P02795 ATP binding; Golgi apparatus; Golgi organization; Golgi vesicle transport; angiogenesis; apoptotic process; cell cortex; cell proliferation; cell-cell junction; cellular response to oxidative stress; cytosol; inflammatory response; innate immune response; integral to plasma membrane; integrin-mediated signaling pathway; intracellular protein kinase cascade; metal ion binding; negative regulation of cell death; negative regulation of endocytosis; nucleus; peptidyl-serine phosphorylation; phospholipid binding; positive regulation of CREB transcription factor activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell proliferation; positive regulation of histone deacetylase activity; positive regulation of neuron projection development; positive regulation of osteoblast differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein autophosphorylation; protein kinase C activity; protein serine/threonine kinase activity; regulation of integrin-mediated signaling pathway; regulation of keratinocyte proliferation; small molecule metabolic process; sphingolipid biosynthetic process; trans-Golgi network IPR020454; IPR011009; IPR011993; IPR001849; IPR002219; IPR000719; IPR017441; IPR015727; IPR002290; IPR008271; Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) PRKD1 PKD PKD1 PRKCM Homo sapiens (Human) TR40232_c0_g1_i6 Q15139 KPCD1_HUMAN 0 GO:0005524; GO:0005794; GO:0007030; GO:0048193; GO:0001525; GO:0006915; GO:0005938; GO:0008283; GO:0005911; GO:0034599; GO:0005829; GO:0006954; GO:0045087; GO:0005887; GO:0007229; GO:0007243; GO:0046872; GO:0060548; GO:0045806; GO:0005634; GO:0018105; GO:0005543; GO:0032793; GO:0043123; GO:0051092; GO:0045766; GO:0043536; GO:0038033; GO:0001938; GO:1901727; GO:0010976; GO:0045669; GO:0033138; GO:0045944; GO:0046777; GO:0004697; GO:0004674; GO:2001044; GO:0010837; GO:0044281; GO:0030148; GO:0005802 Itself; Q07021; P12830; P08238; O15264; P02795 ATP binding; Golgi apparatus; Golgi organization; Golgi vesicle transport; angiogenesis; apoptotic process; cell cortex; cell proliferation; cell-cell junction; cellular response to oxidative stress; cytosol; inflammatory response; innate immune response; integral to plasma membrane; integrin-mediated signaling pathway; intracellular protein kinase cascade; metal ion binding; negative regulation of cell death; negative regulation of endocytosis; nucleus; peptidyl-serine phosphorylation; phospholipid binding; positive regulation of CREB transcription factor activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell proliferation; positive regulation of histone deacetylase activity; positive regulation of neuron projection development; positive regulation of osteoblast differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein autophosphorylation; protein kinase C activity; protein serine/threonine kinase activity; regulation of integrin-mediated signaling pathway; regulation of keratinocyte proliferation; small molecule metabolic process; sphingolipid biosynthetic process; trans-Golgi network IPR020454; IPR011009; IPR011993; IPR001849; IPR002219; IPR000719; IPR017441; IPR015727; IPR002290; IPR008271; Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) PRKD1 PKD PKD1 PRKCM Homo sapiens (Human) TR40233_c0_g1_i1 Q96G03 PGM2_HUMAN 0 GO:0005829; GO:0046386; GO:0019388; GO:0006006; GO:0005978; GO:0005980; GO:0000287; GO:0004614; GO:0008973; GO:0044281 cytosol; deoxyribose phosphate catabolic process; galactose catabolic process; glucose metabolic process; glycogen biosynthetic process; glycogen catabolic process; magnesium ion binding; phosphoglucomutase activity; phosphopentomutase activity; small molecule metabolic process IPR005844; IPR016055; IPR005845; IPR005846; IPR005843; IPR016066; IPR005841; Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 1/2. Phosphoglucomutase-2 (PGM 2) (EC 5.4.2.2) (Glucose phosphomutase 2) (Phosphodeoxyribomutase) (Phosphopentomutase) (EC 5.4.2.7) PGM2 MSTP006 Homo sapiens (Human) TR40235_c0_g1_i1 P70191 TRAF5_MOUSE 1.00E-32 GO:0035631; GO:0006915; GO:0005829; GO:0009898; GO:0043123; GO:0051092; GO:0008284; GO:0042981; GO:0004871; GO:0004842; GO:0008270 P83436; Q6PDM2; Q12933; Q8N7N6 CD40 receptor complex; apoptotic process; cytosol; internal side of plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of cell proliferation; regulation of apoptotic process; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR013323; IPR012227; IPR008974; IPR027130; IPR018957; IPR001841; IPR013083; IPR017907; IPR001293; TNF receptor-associated factor 5 Traf5 Mus musculus (Mouse) TR40235_c0_g1_i2 Q61382 TRAF4_MOUSE 3.00E-172 GO:0006915; GO:0005737; GO:0005856; GO:0005634; GO:0048471; GO:0005886; GO:0046330; GO:0090073; GO:0045860; GO:0042981; GO:0007585; GO:0030323; GO:0007165; GO:0005923; GO:0004842; GO:0008270 apoptotic process; cytoplasm; cytoskeleton; nucleus; perinuclear region of cytoplasm; plasma membrane; positive regulation of JNK cascade; positive regulation of protein homodimerization activity; positive regulation of protein kinase activity; regulation of apoptotic process; respiratory gaseous exchange; respiratory tube development; signal transduction; tight junction; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR013323; IPR012227; IPR008974; IPR018957; IPR001841; IPR013083; IPR017907; IPR001293; TNF receptor-associated factor 4 (Cysteine-rich motif associated to RING and Traf domains protein 1) Traf4 Cart1 Mus musculus (Mouse) TR40235_c0_g1_i3 P70196 TRAF6_MOUSE 5.00E-13 GO:0035631; GO:0007249; GO:0007254; GO:0050852; GO:0042088; GO:0007250; GO:0019886; GO:0045453; GO:0005938; GO:0048468; GO:0005829; GO:0070498; GO:0009898; GO:0005811; GO:0043011; GO:0000122; GO:0001843; GO:0031965; GO:0042475; GO:0001503; GO:0030316; GO:0048471; GO:0043123; GO:0043507; GO:0051092; GO:0002726; GO:0042102; GO:0045084; GO:0032743; GO:0045410; GO:0031666; GO:0045672; GO:0048661; GO:0045944; GO:2000679; GO:0070534; GO:0051865; GO:0006461; GO:0042981; GO:0051023; GO:0004871; GO:0004842; GO:0008270 P27512; Q9QZH6; P17879; Q62406-1; Q61084; Q62227; P35235; Q793I8; O35305; Q8C0E5; Q8N7N6; Q3UDK1; P62991 CD40 receptor complex; I-kappaB kinase/NF-kappaB cascade; JNK cascade; T cell receptor signaling pathway; T-helper 1 type immune response; activation of NF-kappaB-inducing kinase activity; antigen processing and presentation of exogenous peptide antigen via MHC class II; bone resorption; cell cortex; cell development; cytosol; interleukin-1-mediated signaling pathway; internal side of plasma membrane; lipid particle; myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter; neural tube closure; nuclear membrane; odontogenesis of dentin-containing tooth; ossification; osteoclast differentiation; perinuclear region of cytoplasm; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JUN kinase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell cytokine production; positive regulation of T cell proliferation; positive regulation of interleukin-12 biosynthetic process; positive regulation of interleukin-2 production; positive regulation of interleukin-6 biosynthetic process; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of osteoclast differentiation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription regulatory region DNA binding; protein K63-linked ubiquitination; protein autoubiquitination; protein complex assembly; regulation of apoptotic process; regulation of immunoglobulin secretion; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR012227; IPR008974; IPR027139; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. TNF receptor-associated factor 6 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF6) Traf6 Mus musculus (Mouse) TR40235_c0_g1_i4 Q61382 TRAF4_MOUSE 3.00E-44 GO:0006915; GO:0005737; GO:0005856; GO:0005634; GO:0048471; GO:0005886; GO:0046330; GO:0090073; GO:0045860; GO:0042981; GO:0007585; GO:0030323; GO:0007165; GO:0005923; GO:0004842; GO:0008270 apoptotic process; cytoplasm; cytoskeleton; nucleus; perinuclear region of cytoplasm; plasma membrane; positive regulation of JNK cascade; positive regulation of protein homodimerization activity; positive regulation of protein kinase activity; regulation of apoptotic process; respiratory gaseous exchange; respiratory tube development; signal transduction; tight junction; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR013323; IPR012227; IPR008974; IPR018957; IPR001841; IPR013083; IPR017907; IPR001293; TNF receptor-associated factor 4 (Cysteine-rich motif associated to RING and Traf domains protein 1) Traf4 Cart1 Mus musculus (Mouse) TR40236_c0_g2_i1 Q9C0B7 TMCO7_HUMAN 7.00E-151 GO:0016021 integral to membrane IPR011989; IPR016024; IPR019414; IPR019451; Transport and Golgi organization protein 6 homolog (Transmembrane and coiled-coil domain-containing protein 7) TANGO6 KIAA1746 TMCO7 Homo sapiens (Human) TR40236_c1_g1_i4 O88575 S620B_MOUSE 1.00E-66 GO:0016324; GO:0005887; GO:0005328; GO:0005215 apical plasma membrane; integral to plasma membrane; neurotransmitter:sodium symporter activity; transporter activity IPR000175; IPR002438; Sodium- and chloride-dependent transporter XTRP3B (IMINO-K) (Solute carrier family 6 member 20B) Slc6a20b Slc6a20 Xt3 Xtrp3 Mus musculus (Mouse) TR40236_c1_g1_i7 A7Y2W8 SC6A9_XENLA 2.00E-175 GO:0005887; GO:0005328; GO:0005283 integral to plasma membrane; neurotransmitter:sodium symporter activity; sodium:amino acid symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9) slc6a9 glyt1 Xenopus laevis (African clawed frog) TR40237_c0_g2_i1 Q9CWM2 CDCA4_MOUSE 4.00E-09 GO:0005634 nucleus IPR009263; Cell division cycle-associated protein 4 (Hematopoietic progenitor protein) Cdca4 Hepp Mus musculus (Mouse) TR40238_c4_g1_i1 Q9WUA3 K6PP_MOUSE 8.00E-120 GO:0003872; GO:0005945; GO:0005524; GO:0006002; GO:0006096; GO:0046872 6-phosphofructokinase activity; 6-phosphofructokinase complex; ATP binding; fructose 6-phosphate metabolic process; glycolysis; metal ion binding IPR009161; IPR022953; IPR015912; IPR000023; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. 6-phosphofructokinase type C (EC 2.7.1.11) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphofructokinase 1) (Phosphohexokinase) Pfkp Pfkc Mus musculus (Mouse) TR40238_c4_g1_i2 P00511 K6PF_RABIT 3.00E-109 GO:0003872; GO:0005945; GO:0005524; GO:0006002; GO:0006096; GO:0046872 6-phosphofructokinase activity; 6-phosphofructokinase complex; ATP binding; fructose 6-phosphate metabolic process; glycolysis; metal ion binding IPR009161; IPR022953; IPR015912; IPR000023; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. "6-phosphofructokinase, muscle type (EC 2.7.1.11) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphofructokinase-M) (Phosphofructokinase 1) (Phosphohexokinase)" PFKM Oryctolagus cuniculus (Rabbit) TR40238_c4_g1_i3 O94201 K6PF1_CANAX 6.00E-53 GO:0003872; GO:0005945; GO:0005524; GO:0006002; GO:0006096; GO:0046872 6-phosphofructokinase activity; 6-phosphofructokinase complex; ATP binding; fructose 6-phosphate metabolic process; glycolysis; metal ion binding IPR009161; IPR022953; IPR015912; IPR000023; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. 6-phosphofructokinase subunit alpha (EC 2.7.1.11) (6PF-1-K subunit alpha) (CaPFK1) (Phosphofructokinase 1) (Phosphohexokinase) PFK1 Candida albicans (Yeast) TR40238_c4_g2_i1 P52034 K6PF_DROME 0 GO:0003872; GO:0005945; GO:0005524; GO:0006002; GO:0006096 6-phosphofructokinase activity; 6-phosphofructokinase complex; ATP binding; fructose 6-phosphate metabolic process; glycolysis IPR009161; IPR022953; IPR015912; IPR000023; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. 6-phosphofructokinase (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase) Pfk CG4001 Drosophila melanogaster (Fruit fly) TR40238_c4_g2_i2 P47859 K6PP_RABIT 0 GO:0003872; GO:0005945; GO:0005524; GO:0006002; GO:0006096; GO:0046872 6-phosphofructokinase activity; 6-phosphofructokinase complex; ATP binding; fructose 6-phosphate metabolic process; glycolysis; metal ion binding IPR009161; IPR022953; IPR015912; IPR000023; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. 6-phosphofructokinase type C (EC 2.7.1.11) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphofructokinase 1) (Phosphohexokinase) PFKP Oryctolagus cuniculus (Rabbit) TR40239_c1_g1_i1 Q9SAY1 SUT11_ARATH 9.00E-14 GO:0016021; GO:0008271; GO:0080160; GO:0008272; GO:0015293 integral to membrane; secondary active sulfate transmembrane transporter activity; selenate transport; sulfate transport; symporter activity IPR018045; IPR002645; IPR001902; IPR011547; Sulfate transporter 1.1 (AST101) (High-affinity sulfate transporter 1) (Hst1At) SULTR1;1 HST1 At4g08620 T3F12.7 Arabidopsis thaliana (Mouse-ear cress) TR40239_c2_g5_i2 Q924C9 S26A3_RAT 7.00E-38 GO:0015301; GO:0016324; GO:0015106; GO:0031526; GO:0071320; GO:0015108; GO:0016021; GO:0051454; GO:0060081; GO:0008271; GO:0048240; GO:0097225; GO:0008272 anion:anion antiporter activity; apical plasma membrane; bicarbonate transmembrane transporter activity; brush border membrane; cellular response to cAMP; chloride transmembrane transporter activity; integral to membrane; intracellular pH elevation; membrane hyperpolarization; secondary active sulfate transmembrane transporter activity; sperm capacitation; sperm midpiece; sulfate transport IPR018045; IPR002645; IPR001902; IPR011547; Chloride anion exchanger (Down-regulated in adenoma) (Protein DRA) (Solute carrier family 26 member 3) Slc26a3 Dra Rattus norvegicus (Rat) TR40239_c2_g5_i5 Q924C9 S26A3_RAT 7.00E-35 GO:0015301; GO:0016324; GO:0015106; GO:0031526; GO:0071320; GO:0015108; GO:0016021; GO:0051454; GO:0060081; GO:0008271; GO:0048240; GO:0097225; GO:0008272 anion:anion antiporter activity; apical plasma membrane; bicarbonate transmembrane transporter activity; brush border membrane; cellular response to cAMP; chloride transmembrane transporter activity; integral to membrane; intracellular pH elevation; membrane hyperpolarization; secondary active sulfate transmembrane transporter activity; sperm capacitation; sperm midpiece; sulfate transport IPR018045; IPR002645; IPR001902; IPR011547; Chloride anion exchanger (Down-regulated in adenoma) (Protein DRA) (Solute carrier family 26 member 3) Slc26a3 Dra Rattus norvegicus (Rat) TR40239_c2_g8_i1 Q9BXS9 S26A6_HUMAN 2.00E-41 GO:0030165; GO:0038166; GO:0015301; GO:0016324; GO:0016323; GO:0015106; GO:0031526; GO:0071320; GO:0071332; GO:0071346; GO:0005254; GO:0034707; GO:0015108; GO:0030659; GO:0005783; GO:0042045; GO:0015660; GO:0015659; GO:0016021; GO:0005887; GO:0050892; GO:0051454; GO:0015797; GO:0019531; GO:0046724; GO:0005886; GO:2001150; GO:0070528; GO:0051453; GO:0008271; GO:0048240; GO:0097225; GO:0015116; GO:0008272; GO:0030321; GO:0012506 PDZ domain binding; angiotensin-mediated signaling pathway; anion:anion antiporter activity; apical plasma membrane; basolateral plasma membrane; bicarbonate transmembrane transporter activity; brush border membrane; cellular response to cAMP; cellular response to fructose stimulus; cellular response to interferon-gamma; chloride channel activity; chloride channel complex; chloride transmembrane transporter activity; cytoplasmic vesicle membrane; endoplasmic reticulum; epithelial fluid transport; formate efflux transmembrane transporter activity; formate uptake transmembrane transporter activity; integral to membrane; integral to plasma membrane; intestinal absorption; intracellular pH elevation; mannitol transport; oxalate transmembrane transporter activity; oxalic acid secretion; plasma membrane; positive regulation of dipeptide transmembrane transport; protein kinase C signaling cascade; regulation of intracellular pH; secondary active sulfate transmembrane transporter activity; sperm capacitation; sperm midpiece; sulfate transmembrane transporter activity; sulfate transport; transepithelial chloride transport; vesicle membrane IPR018045; IPR002645; IPR001902; IPR011547; Solute carrier family 26 member 6 (Anion exchange transporter) (Pendrin-like protein 1) (Pendrin-L1) SLC26A6 Homo sapiens (Human) TR40240_c0_g1_i2 Q5TYV0 EMC7_DANRE 2.00E-45 GO:0072546; GO:0030246 ER membrane protein complex; carbohydrate binding IPR013784; IPR019008; ER membrane protein complex subunit 7 emc7 si:ch211-150c22.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR40243_c0_g1_i2 Q9BS26 ERP44_HUMAN 1.00E-140 GO:0045454; GO:0009986; GO:0005788; GO:0005789; GO:0005793; GO:0009100; GO:0003756; GO:0034976; GO:0006986 P49257 cell redox homeostasis; cell surface; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; glycoprotein metabolic process; protein disulfide isomerase activity; response to endoplasmic reticulum stress; response to unfolded protein IPR012336; IPR013766; Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4) ERP44 KIAA0573 TXNDC4 UNQ532/PRO1075 Homo sapiens (Human) TR40244_c0_g1_i1 Q9NRA2 S17A5_HUMAN 1.00E-131 GO:0006865; GO:0030054; GO:0005887; GO:0005765; GO:0015136; GO:0015739; GO:0005351; GO:0030672 amino acid transport; cell junction; integral to plasma membrane; lysosomal membrane; sialic acid transmembrane transporter activity; sialic acid transport; sugar:hydrogen symporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) TR40244_c0_g1_i2 Q9NRA2 S17A5_HUMAN 1.00E-131 GO:0006865; GO:0030054; GO:0005887; GO:0005765; GO:0015136; GO:0015739; GO:0005351; GO:0030672 amino acid transport; cell junction; integral to plasma membrane; lysosomal membrane; sialic acid transmembrane transporter activity; sialic acid transport; sugar:hydrogen symporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) TR40246_c2_g1_i1 Q8VHK2 CSKI1_RAT 7.00E-20 GO:0005737; GO:0019904; GO:0007165 Q9NYB9 cytoplasm; protein domain specific binding; signal transduction IPR002110; IPR020683; IPR027013; IPR027001; IPR001660; IPR013761; IPR021129; IPR011511; IPR001452; Caskin-1 (CASK-interacting protein 1) Caskin1 Rattus norvegicus (Rat) TR40246_c2_g1_i2 Q8K4M9 OSBL1_RAT 3.00E-10 GO:0005770; GO:0006869; GO:0005543 late endosome; lipid transport; phospholipid binding IPR002110; IPR020683; IPR000648; IPR018494; IPR011993; IPR001849; Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1) Osbpl1a Orp1 Rattus norvegicus (Rat) TR40246_c4_g1_i1 P54760 EPHB4_HUMAN 9.00E-06 GO:0005524; GO:0007155; GO:0002042; GO:0009986; GO:0005003; GO:0003007; GO:0005887; GO:0046777 ATP binding; cell adhesion; cell migration involved in sprouting angiogenesis; cell surface; ephrin receptor activity; heart morphogenesis; integral to plasma membrane; protein autophosphorylation IPR027936; IPR001090; IPR003961; IPR008979; IPR009030; IPR013783; IPR011009; IPR000719; IPR017441; IPR001660; IPR013761; IPR021129; IPR001245; IPR011641; IPR008266; IPR020635; IPR016257; IPR001426; Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) EPHB4 HTK MYK1 TYRO11 Homo sapiens (Human) TR40246_c4_g1_i3 Q8BYG9 EPHAA_MOUSE 9.00E-08 GO:0005524; GO:0005003; GO:0005887; GO:0018108 ATP binding; ephrin receptor activity; integral to plasma membrane; peptidyl-tyrosine phosphorylation IPR027936; IPR001090; IPR003961; IPR008979; IPR013783; IPR011009; IPR000719; IPR001660; IPR013761; IPR021129; IPR001245; IPR020635; IPR016257; IPR001426; Ephrin type-A receptor 10 (EC 2.7.10.1) Epha10 Mus musculus (Mouse) TR40246_c4_g2_i1 Q8BIZ1 ANS1B_MOUSE 6.00E-53 GO:0030054; GO:0005737; GO:0043197; GO:0005634; GO:0014069; GO:0045211 cell junction; cytoplasm; dendritic spine; nucleus; postsynaptic density; postsynaptic membrane IPR002110; IPR020683; IPR011993; IPR006020; IPR001660; IPR013761; IPR021129; Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) Anks1b Mus musculus (Mouse) TR40246_c4_g2_i3 P0C6S7 ANS1B_RAT 4.00E-53 GO:0015030; GO:0030054; GO:0005737; GO:0043197; GO:0014069; GO:0045211 Cajal body; cell junction; cytoplasm; dendritic spine; postsynaptic density; postsynaptic membrane IPR002110; IPR020683; IPR011993; IPR006020; IPR001660; IPR013761; IPR021129; Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) Anks1b Rattus norvegicus (Rat) TR40249_c0_g1_i1 Q9BZE4 NOG1_HUMAN 0 GO:0005525; GO:0003924; GO:0005794; GO:0008156; GO:0030336; GO:0008285; GO:0022408; GO:0033342; GO:0031397; GO:0031965; GO:0005730; GO:0048471; GO:0050821; GO:0000079; GO:0042254 P35240 GTP binding; GTPase activity; Golgi apparatus; negative regulation of DNA replication; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell-cell adhesion; negative regulation of collagen binding; negative regulation of protein ubiquitination; nuclear membrane; nucleolus; perinuclear region of cytoplasm; protein stabilization; regulation of cyclin-dependent protein serine/threonine kinase activity; ribosome biogenesis IPR006073; IPR024926; IPR010674; IPR012973; IPR027417; IPR005225; Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB) GTPBP4 CRFG NOG1 Homo sapiens (Human) TR40249_c0_g1_i4 Q9BZE4 NOG1_HUMAN 0 GO:0005525; GO:0003924; GO:0005794; GO:0008156; GO:0030336; GO:0008285; GO:0022408; GO:0033342; GO:0031397; GO:0031965; GO:0005730; GO:0048471; GO:0050821; GO:0000079; GO:0042254 P35240 GTP binding; GTPase activity; Golgi apparatus; negative regulation of DNA replication; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell-cell adhesion; negative regulation of collagen binding; negative regulation of protein ubiquitination; nuclear membrane; nucleolus; perinuclear region of cytoplasm; protein stabilization; regulation of cyclin-dependent protein serine/threonine kinase activity; ribosome biogenesis IPR006073; IPR024926; IPR010674; IPR012973; IPR027417; IPR005225; Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB) GTPBP4 CRFG NOG1 Homo sapiens (Human) TR40252_c0_g1_i1 Q7SXF1 DHCR7_DANRE 3.00E-29 GO:0047598; GO:0006695; GO:0005789; GO:0016021 7-dehydrocholesterol reductase activity; cholesterol biosynthetic process; endoplasmic reticulum membrane; integral to membrane IPR001171; IPR018083; Steroid biosynthesis; cholesterol biosynthesis. 7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Sterol Delta(7)-reductase) dhcr7 Danio rerio (Zebrafish) (Brachydanio rerio) TR40252_c0_g1_i3 Q5R7H4 LBR_PONAB 4.00E-63 GO:0003677; GO:0016021; GO:0005637; GO:0016628 "DNA binding; integral to membrane; nuclear inner membrane; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor" IPR001171; IPR019023; IPR018083; IPR002999; Lamin-B receptor (Integral nuclear envelope inner membrane protein) LBR Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40253_c2_g2_i3 P82103 MYNA_MYTGA 4.00E-24 GO:0042742; GO:0005576 defense response to bacterium; extracellular region IPR019631; Myticin-A Mytilus galloprovincialis (Mediterranean mussel) TR40253_c2_g2_i4 P82102 MYNB_MYTGA 1.00E-23 GO:0042742; GO:0050832; GO:0005576; GO:0031640 defense response to bacterium; defense response to fungus; extracellular region; killing of cells of other organism IPR019631; Myticin-B Mytilus galloprovincialis (Mediterranean mussel) TR40254_c2_g1_i1 Q70E20 SNED1_MOUSE 3.00E-59 GO:0005509; GO:0007160; GO:0005576 calcium ion binding; cell-matrix adhesion; extracellular region IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003961; IPR009030; IPR013783; IPR003886; IPR000436; "Sushi, nidogen and EGF-like domain-containing protein 1 (Secreted protein SST-3) (Stromal nidogen extracellular matrix protein)" Sned1 Snep Mus musculus (Mouse) TR40254_c2_g1_i3 Q9YH85 TECTA_CHICK 5.00E-47 GO:0031225; GO:0007160; GO:0005886; GO:0005578; GO:0007605 anchored to membrane; cell-matrix adhesion; plasma membrane; proteinaceous extracellular matrix; sensory perception of sound IPR000742; IPR003886; IPR002919; IPR025615; IPR014853; IPR006552; IPR001846; IPR001507; IPR017977; Alpha-tectorin TECTA Gallus gallus (Chicken) TR40254_c2_g1_i4 Q14112 NID2_HUMAN 3.00E-21 GO:0005604; GO:0005509; GO:0007155; GO:0009986; GO:0007160; GO:0005518 basement membrane; calcium ion binding; cell adhesion; cell surface; cell-matrix adhesion; collagen binding IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR006605; IPR009017; IPR023413; IPR009030; IPR000033; IPR003886; IPR000716; Nidogen-2 (NID-2) (Osteonidogen) NID2 Homo sapiens (Human) TR40256_c3_g4_i5 Q5UP57 P4H_MIMIV 2.00E-09 GO:0031418; GO:0005506; GO:0004656; GO:0019012 L-ascorbic acid binding; iron ion binding; procollagen-proline 4-dioxygenase activity; virion IPR005123; IPR006620; "Putative prolyl 4-hydroxylase (4-PH) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase)" MIMI_L593 Acanthamoeba polyphaga mimivirus (APMV) TR40257_c3_g2_i1 Q6IA17 SIGIR_HUMAN 1.00E-07 GO:0006953; GO:0016021; GO:0016020; GO:0045079; GO:0001960; GO:0031665; GO:0043433; GO:0007165 acute-phase response; integral to membrane; membrane; negative regulation of chemokine biosynthetic process; negative regulation of cytokine-mediated signaling pathway; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of sequence-specific DNA binding transcription factor activity; signal transduction IPR007110; IPR013783; IPR015621; IPR000157; Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8) SIGIRR UNQ301/PRO342 Homo sapiens (Human) TR40257_c4_g1_i2 Q8SPE9 TLR4_PONPY 3.00E-16 GO:0002755; GO:0050829; GO:0032497; GO:0006954; GO:0045087; GO:0001875; GO:0046696; GO:0042116; GO:0050707; GO:0034142; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-negative bacterium; detection of lipopolysaccharide; inflammatory response; innate immune response; lipopolysaccharide receptor activity; lipopolysaccharide receptor complex; macrophage activation; regulation of cytokine secretion; toll-like receptor 4 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR025875; IPR003591; IPR000157; IPR027168; IPR017241; Toll-like receptor 4 (CD antigen CD284) TLR4 Pongo pygmaeus (Bornean orangutan) TR40257_c4_g1_i4 P08953 TOLL_DROME 2.00E-32 GO:0033565; GO:0008063; GO:0019732; GO:0007155; GO:0019955; GO:0050830; GO:0005769; GO:0009897; GO:0007507; GO:0035172; GO:0030097; GO:0045087; GO:0016021; GO:0006963; GO:0006967; GO:0045610; GO:0007416; GO:0016201; GO:0004888; GO:0007352 Itself; Q7K105 ESCRT-0 complex; Toll signaling pathway; antifungal humoral response; cell adhesion; cytokine binding; defense response to Gram-positive bacterium; early endosome; external side of plasma membrane; heart development; hemocyte proliferation; hemopoiesis; innate immune response; integral to membrane; positive regulation of antibacterial peptide biosynthetic process; positive regulation of antifungal peptide biosynthetic process; regulation of hemocyte differentiation; synapse assembly; synaptic target inhibition; transmembrane signaling receptor activity; zygotic specification of dorsal/ventral axis IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) TR40257_c4_g1_i5 Q9QUN7 TLR2_MOUSE 2.00E-21 GO:0002755; GO:0035354; GO:0035355; GO:0002752; GO:0071221; GO:0071223; GO:0071224; GO:0042892; GO:0050830; GO:0042498; GO:0009897; GO:0052063; GO:0006954; GO:0045087; GO:0016021; GO:0070891; GO:0044130; GO:0032695; GO:0032700; GO:0030670; GO:0032722; GO:0050715; GO:0050729; GO:0032728; GO:0032735; GO:0032741; GO:0032755; GO:0002687; GO:0060907; GO:0045429; GO:0051770; GO:0045944; GO:0042535; GO:0032760; GO:0046982; GO:0002238; GO:0034134; GO:0004888; GO:0042497 MyD88-dependent toll-like receptor signaling pathway; Toll-like receptor 1-Toll-like receptor 2 protein complex; Toll-like receptor 2-Toll-like receptor 6 protein complex; cell surface pattern recognition receptor signaling pathway; cellular response to bacterial lipopeptide; cellular response to lipoteichoic acid; cellular response to peptidoglycan; chloramphenicol transport; defense response to Gram-positive bacterium; diacyl lipopeptide binding; external side of plasma membrane; induction by symbiont of defense-related host nitric oxide production; inflammatory response; innate immune response; integral to membrane; lipoteichoic acid binding; negative regulation of growth of symbiont in host; negative regulation of interleukin-12 production; negative regulation of interleukin-17 production; phagocytic vesicle membrane; positive regulation of chemokine production; positive regulation of cytokine secretion; positive regulation of inflammatory response; positive regulation of interferon-beta production; positive regulation of interleukin-12 production; positive regulation of interleukin-18 production; positive regulation of interleukin-6 production; positive regulation of leukocyte migration; positive regulation of macrophage cytokine production; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of tumor necrosis factor production; protein heterodimerization activity; response to molecule of fungal origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity; triacyl lipopeptide binding IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) Tlr2 Mus musculus (Mouse) TR40257_c4_g1_i6 P0CC10 LRC4B_RAT 1.00E-10 GO:0030054; GO:0016021; GO:0051965; GO:0042734 cell junction; integral to membrane; positive regulation of synapse assembly; presynaptic membrane IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; IPR026906; IPR026883; Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3) Lrrc4b Lrig4 Rattus norvegicus (Rat) TR40257_c4_g1_i7 Q13478 IL18R_HUMAN 9.00E-10 GO:0045063; GO:0006955; GO:0016021; GO:0004908; GO:0042008; GO:0030101; GO:0005886; GO:0042346; GO:0032729; GO:0004872; GO:0007165 T-helper 1 cell differentiation; immune response; integral to membrane; interleukin-1 receptor activity; interleukin-18 receptor activity; natural killer cell activation; plasma membrane; positive regulation of NF-kappaB import into nucleus; positive regulation of interferon-gamma production; receptor activity; signal transduction IPR007110; IPR013783; IPR003599; IPR015621; IPR004074; IPR000157; Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (CD218 antigen-like family member A) (CDw218a) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (CD antigen CD218a) IL18R1 IL1RRP Homo sapiens (Human) TR40257_c4_g1_i8 A6NM62 LRC53_HUMAN 3.00E-06 GO:0016021 integral to membrane IPR001611; IPR003591; Leucine-rich repeat-containing protein 53 LRRC53 Homo sapiens (Human) TR40258_c0_g1_i2 Q803I8 SYVN1_DANRE 0 GO:0030433; GO:0005789; GO:0016021; GO:0016874; GO:0018279; GO:0016567; GO:0008270 ER-associated protein catabolic process; endoplasmic reticulum membrane; integral to membrane; ligase activity; protein N-linked glycosylation via asparagine; protein ubiquitination; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase synoviolin (EC 6.3.2.-) (Synovial apoptosis inhibitor 1) syvn1 hrd1 zgc:55735 zgc:77108 Danio rerio (Zebrafish) (Brachydanio rerio) TR40258_c0_g1_i4 Q803I8 SYVN1_DANRE 1.00E-72 GO:0030433; GO:0005789; GO:0016021; GO:0016874; GO:0018279; GO:0016567; GO:0008270 ER-associated protein catabolic process; endoplasmic reticulum membrane; integral to membrane; ligase activity; protein N-linked glycosylation via asparagine; protein ubiquitination; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase synoviolin (EC 6.3.2.-) (Synovial apoptosis inhibitor 1) syvn1 hrd1 zgc:55735 zgc:77108 Danio rerio (Zebrafish) (Brachydanio rerio) TR40258_c1_g1_i2 P97494 GSH1_MOUSE 0 GO:0043531; GO:0005524; GO:0019852; GO:0008637; GO:0045454; GO:0050662; GO:0006534; GO:0005829; GO:0016595; GO:0006536; GO:0004357; GO:0017109; GO:0006750; GO:0000287; GO:0043066; GO:2001237; GO:0043524; GO:0031397; GO:0045892; GO:0032436; GO:0050880; GO:0051900; GO:0046685; GO:0009408; GO:0009725; GO:0051409; GO:0006979; GO:0009410 "ADP binding; ATP binding; L-ascorbic acid metabolic process; apoptotic mitochondrial changes; cell redox homeostasis; coenzyme binding; cysteine metabolic process; cytosol; glutamate binding; glutamate metabolic process; glutamate-cysteine ligase activity; glutamate-cysteine ligase complex; glutathione biosynthetic process; magnesium ion binding; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of neuron apoptotic process; negative regulation of protein ubiquitination; negative regulation of transcription, DNA-dependent; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of blood vessel size; regulation of mitochondrial depolarization; response to arsenic-containing substance; response to heat; response to hormone stimulus; response to nitrosative stress; response to oxidative stress; response to xenobiotic stimulus" IPR004308; Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase) Gclc Glclc Mus musculus (Mouse) TR40258_c1_g1_i3 Q9NFN6 GSH1_ONCVO 0 GO:0005524; GO:0004357; GO:0006750 ATP binding; glutamate-cysteine ligase activity; glutathione biosynthetic process IPR004308; Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. Glutamate--cysteine ligase (EC 6.3.2.2) (Gamma-ECS) (GCS) (Gamma-glutamylcysteine synthetase) gcs-1 Onchocerca volvulus TR40259_c0_g1_i1 Q8R409 HEXI1_MOUSE 4.00E-15 GO:0004861; GO:0005737; GO:0007507; GO:0045736; GO:0000122; GO:0005634; GO:0017069; GO:0006351 "cyclin-dependent protein serine/threonine kinase inhibitor activity; cytoplasm; heart development; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of transcription from RNA polymerase II promoter; nucleus; snRNA binding; transcription, DNA-dependent" IPR024872; Protein HEXIM1 (Cardiac lineage protein 1) Hexim1 Clp1 Mus musculus (Mouse) TR40260_c0_g1_i1 Q9LVX0 ARI3_ARATH 3.00E-15 GO:0016874; GO:0016567; GO:0008270 ligase activity; protein ubiquitination; zinc ion binding IPR002867; IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase ARI3 (EC 6.3.2.-) (ARIADNE-like protein ARI3) (Protein ariadne homolog 3) ARI3 At3g27710 MGF10.7 Arabidopsis thaliana (Mouse-ear cress) TR40260_c0_g1_i3 P0C8K8 ARI6_ARATH 9.00E-12 GO:0016874; GO:0003676; GO:0016567; GO:0008270 ligase activity; nucleic acid binding; protein ubiquitination; zinc ion binding IPR002867; IPR001878; IPR001841; IPR013083; Protein modification; protein ubiquitination. Putative E3 ubiquitin-protein ligase ARI6 (EC 6.3.2.-) (ARIADNE-like protein ARI6) (Protein ariadne homolog 6) ARI6 At1g63760 F24D7.5 Arabidopsis thaliana (Mouse-ear cress) TR40260_c0_g1_i4 Q9LVW9 ARI4_ARATH 5.00E-15 GO:0016874; GO:0016567; GO:0008270 ligase activity; protein ubiquitination; zinc ion binding IPR002867; IPR001841; IPR013083; Protein modification; protein ubiquitination. Putative E3 ubiquitin-protein ligase ARI4 (EC 6.3.2.-) (ARIADNE-like protein ARI4) (Protein ariadne homolog 4) ARI4 At3g27720 MGF10.12 Arabidopsis thaliana (Mouse-ear cress) TR40261_c0_g1_i5 Q7Z7K0 COXM1_HUMAN 6.00E-21 GO:0046872; GO:0005739 metal ion binding; mitochondrion IPR013892; COX assembly mitochondrial protein homolog (Cmc1p) CMC1 C3orf68 Homo sapiens (Human) TR40262_c3_g2_i1 O43670 ZN207_HUMAN 2.00E-29 GO:0003677; GO:0008201; GO:0005634; GO:0003700; GO:0008270 DNA binding; heparin binding; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding IPR007087; IPR015880; Zinc finger protein 207 ZNF207 Homo sapiens (Human) TR40263_c0_g1_i1 O94915 FRYL_HUMAN 4.00E-37 GO:0006355; GO:0006351 Q16611; P31946; P61981 "regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011989; IPR016024; IPR025614; IPR025481; Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) FRYL AF4P12 KIAA0826 Homo sapiens (Human) TR40263_c7_g2_i1 Q9VT28 FRY_DROME 2.00E-142 GO:0048800; GO:0045177; GO:0005938; GO:0008407; GO:0070593; GO:0035317; GO:0048601; GO:0045860; GO:0045893; GO:0048814; GO:0042052; GO:0006351 "antennal morphogenesis; apical part of cell; cell cortex; chaeta morphogenesis; dendrite self-avoidance; imaginal disc-derived wing hair organization; oocyte morphogenesis; positive regulation of protein kinase activity; positive regulation of transcription, DNA-dependent; regulation of dendrite morphogenesis; rhabdomere development; transcription, DNA-dependent" IPR016024; IPR025614; IPR025481; Protein furry fry CG32045 Drosophila melanogaster (Fruit fly) TR40263_c7_g2_i2 Q9VT28 FRY_DROME 8.00E-144 GO:0048800; GO:0045177; GO:0005938; GO:0008407; GO:0070593; GO:0035317; GO:0048601; GO:0045860; GO:0045893; GO:0048814; GO:0042052; GO:0006351 "antennal morphogenesis; apical part of cell; cell cortex; chaeta morphogenesis; dendrite self-avoidance; imaginal disc-derived wing hair organization; oocyte morphogenesis; positive regulation of protein kinase activity; positive regulation of transcription, DNA-dependent; regulation of dendrite morphogenesis; rhabdomere development; transcription, DNA-dependent" IPR016024; IPR025614; IPR025481; Protein furry fry CG32045 Drosophila melanogaster (Fruit fly) TR40265_c1_g1_i1 A3DHZ7 RECF_CLOTH 8.00E-07 GO:0005524; GO:0006281; GO:0006260; GO:0009432; GO:0005737; GO:0003697 ATP binding; DNA repair; DNA replication; SOS response; cytoplasm; single-stranded DNA binding IPR001238; IPR018078; IPR027417; IPR003395; DNA replication and repair protein RecF recF Cthe_2374 Clostridium thermocellum (strain ATCC 27405 / DSM 1237) TR40265_c2_g1_i1 P97690 SMC3_RAT 0 GO:0005524; GO:0006281; GO:0005604; GO:0051301; GO:0000785; GO:0051276; GO:0005737; GO:0045502; GO:0007126; GO:0030893; GO:0007067; GO:0007052; GO:0016363; GO:0006275; GO:0007165; GO:0000922 ATP binding; DNA repair; basement membrane; cell division; chromatin; chromosome organization; cytoplasm; dynein binding; meiosis; meiotic cohesin complex; mitosis; mitotic spindle organization; nuclear matrix; regulation of DNA replication; signal transduction; spindle pole IPR027417; IPR003395; IPR010935; Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) Smc3 Bam Bmh Cspg6 Smc3l1 Rattus norvegicus (Rat) TR40265_c2_g2_i1 O93309 SMC3_XENLA 0 GO:0005524; GO:0006281; GO:0051301; GO:0000785; GO:0051276; GO:0000775; GO:0007126; GO:0030893; GO:0007067; GO:0005634; GO:0006275 Q4QXM3; Q9DGN1; Q9DGN0 "ATP binding; DNA repair; cell division; chromatin; chromosome organization; chromosome, centromeric region; meiosis; meiotic cohesin complex; mitosis; nucleus; regulation of DNA replication" IPR027417; IPR003395; IPR010935; Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) smc3 smc3l1 Xenopus laevis (African clawed frog) TR40265_c2_g2_i2 Q59037 SMC_METJA 3.00E-27 GO:0005524; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0005694; GO:0030261; GO:0005737; GO:0007062 ATP binding; DNA binding; DNA recombination; DNA repair; DNA replication; chromosome; chromosome condensation; cytoplasm; sister chromatid cohesion IPR027417; IPR003395; IPR024704; IPR010935; IPR011890; Chromosome partition protein Smc smc MJ1643 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR40266_c2_g2_i1 Q9QXM1 JMY_MOUSE 1.00E-07 GO:0070060; GO:0034314; GO:0006281; GO:0070358; GO:0007050; GO:0031252; GO:0005737; GO:0005856; GO:0072332; GO:0005634; GO:0043065; GO:0051091; GO:0043620; GO:0006357; GO:0003713 Q09472 'de novo' actin filament nucleation; Arp2/3 complex-mediated actin nucleation; DNA repair; actin polymerization-dependent cell motility; cell cycle arrest; cell leading edge; cytoplasm; cytoskeleton; intrinsic apoptotic signaling pathway by p53 class mediator; nucleus; positive regulation of apoptotic process; positive regulation of sequence-specific DNA binding transcription factor activity; regulation of DNA-dependent transcription in response to stress; regulation of transcription from RNA polymerase II promoter; transcription coactivator activity IPR003124; Junction-mediating and -regulatory protein Jmy Mus musculus (Mouse) TR40266_c4_g1_i2 Q8N9B5 JMY_HUMAN 2.00E-34 GO:0070060; GO:0034314; GO:0006281; GO:0070358; GO:0007050; GO:0031252; GO:0005737; GO:0005856; GO:0005634; GO:0043065; GO:0051091; GO:0006357; GO:0003713 Q00987 'de novo' actin filament nucleation; Arp2/3 complex-mediated actin nucleation; DNA repair; actin polymerization-dependent cell motility; cell cycle arrest; cell leading edge; cytoplasm; cytoskeleton; nucleus; positive regulation of apoptotic process; positive regulation of sequence-specific DNA binding transcription factor activity; regulation of transcription from RNA polymerase II promoter; transcription coactivator activity IPR003124; Junction-mediating and -regulatory protein JMY Homo sapiens (Human) TR40267_c4_g1_i3 Q5U252 UBP47_XENLA 0 GO:0006284; GO:0005737; GO:0035520; GO:0004221; GO:0006511; GO:0004843 base-excision repair; cytoplasm; monoubiquitinated protein deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR018200; IPR001394; IPR027933; Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) usp47 Xenopus laevis (African clawed frog) TR40269_c0_g1_i1 Q86X10 RLGPB_HUMAN 0 GO:0017123; GO:0032484; GO:0032859; GO:0046982; GO:0060178 Ral GTPase activator activity; Ral protein signal transduction; activation of Ral GTPase activity; protein heterodimerization activity; regulation of exocyst localization IPR000331; Ral GTPase-activating protein subunit beta (p170) RALGAPB KIAA1219 Homo sapiens (Human) TR40269_c0_g1_i4 P86410 RLGPB_RAT 6.00E-69 GO:0017123; GO:0032859; GO:0046982 Ral GTPase activator activity; activation of Ral GTPase activity; protein heterodimerization activity IPR000331; Ral GTPase-activating protein subunit beta (p170) Ralgapb Rattus norvegicus (Rat) TR40270_c1_g1_i2 Q9EPL8 IPO7_MOUSE 0 GO:0005794; GO:0042393; GO:0005634; GO:0006606 Golgi apparatus; histone binding; nucleus; protein import into nucleus IPR011989; IPR016024; IPR013713; IPR001494; Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7) Ipo7 Ranbp7 Mus musculus (Mouse) TR40272_c1_g1_i2 Q9NNZ3 DNJC4_HUMAN 2.00E-15 GO:0016021; GO:0016020; GO:0005739; GO:0006457; GO:0006986; GO:0051082 integral to membrane; membrane; mitochondrion; protein folding; response to unfolded protein; unfolded protein binding IPR001623; DnaJ homolog subfamily C member 4 (DnaJ-like protein HSPF2) (Multiple endocrine neoplasia type 1 candidate protein number 18) DNAJC4 HSPF2 MCG18 Homo sapiens (Human) TR40272_c1_g1_i4 Q7ZYF1 DJ27A_XENLA 2.00E-06 GO:0005525; GO:0007264 GTP binding; small GTPase mediated signal transduction IPR001623; IPR027417; IPR005225; IPR001806; DnaJ homolog subfamily C member 27-A (Rab and DnaJ domain-containing protein 1) (Rab and DnaJ domain-containing protein A) dnajc27-a rbj-a rbj1 Xenopus laevis (African clawed frog) TR40273_c0_g2_i1 Q6Q4G4 ACE_THETS 3.00E-157 GO:0004180; GO:0005615; GO:0016020; GO:0046872; GO:0008237; GO:0008241; GO:0006508 carboxypeptidase activity; extracellular space; membrane; metal ion binding; metallopeptidase activity; peptidyl-dipeptidase activity; proteolysis IPR001548; Angiotensin-converting enzyme (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (TtACE) ACE Theromyzon tessulatum (Duck leech) TR40273_c0_g2_i2 Q50JE5 ACE_MESAU 8.00E-156 GO:0004180; GO:0005576; GO:0016021; GO:0046872; GO:0008237; GO:0008241; GO:0005886; GO:0006508 carboxypeptidase activity; extracellular region; integral to membrane; metal ion binding; metallopeptidase activity; peptidyl-dipeptidase activity; plasma membrane; proteolysis IPR001548; "Angiotensin-converting enzyme (ACE) (EC 3.2.1.-) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form]" Ace Dcp1 Mesocricetus auratus (Golden hamster) TR40274_c0_g1_i1 Q96JP0 FEM1C_HUMAN 0 GO:0005737; GO:0016567 cytoplasm; protein ubiquitination IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog C (FEM1c) (FEM1-gamma) FEM1C KIAA1785 Homo sapiens (Human) TR40274_c0_g1_i3 Q96JP0 FEM1C_HUMAN 2.00E-43 GO:0005737; GO:0016567 cytoplasm; protein ubiquitination IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog C (FEM1c) (FEM1-gamma) FEM1C KIAA1785 Homo sapiens (Human) TR40275_c1_g1_i1 Q9U3K5 INX2_CAEEL 8.00E-28 GO:0005921; GO:0055077; GO:0016021; GO:0006811; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transport; plasma membrane IPR000990; Innexin-2 (Protein opu-2) inx-2 opu-2 F08G12.10 Caenorhabditis elegans TR40275_c1_g1_i4 O01393 UNC9_CAEEL 8.00E-63 GO:0005921; GO:0055077; GO:0016021; GO:0034220; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transmembrane transport; plasma membrane IPR000990; Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans TR40280_c0_g2_i1 Q8NIV6 SPT6_NEUCR 2.00E-31 GO:0003677; GO:0003723; GO:0016788; GO:0005634; GO:0032784; GO:0006357; GO:0006351 "DNA binding; RNA binding; hydrolase activity, acting on ester bonds; nucleus; regulation of DNA-dependent transcription, elongation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR012340; IPR003029; IPR022967; IPR012337; IPR010994; IPR000980; IPR028083; IPR027999; IPR028088; IPR028231; IPR023323; IPR023097; IPR017072; IPR006641; Transcription elongation factor spt-6 (Chromatin elongation factor spt-6) spt-6 NCU04611 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR40280_c0_g6_i1 Q7KZ85 SPT6H_HUMAN 0 GO:0003677; GO:0003723; GO:0008380; GO:0006338; GO:0042393; GO:0016788; GO:0006397; GO:0051028; GO:0019048; GO:0061086; GO:0005634; GO:0032968; GO:0045191; GO:0010793; GO:0050684; GO:0051147; GO:0003700; GO:0006351 P04626 "DNA binding; RNA binding; RNA splicing; chromatin remodeling; histone binding; hydrolase activity, acting on ester bonds; mRNA processing; mRNA transport; modulation by virus of host morphology or physiology; negative regulation of histone H3-K27 methylation; nucleus; positive regulation of transcription elongation from RNA polymerase II promoter; regulation of isotype switching; regulation of mRNA export from nucleus; regulation of mRNA processing; regulation of muscle cell differentiation; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR012340; IPR003029; IPR022967; IPR012337; IPR010994; IPR000980; IPR028083; IPR027999; IPR028088; IPR028231; IPR023323; IPR023097; IPR017072; IPR006641; Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) SUPT6H KIAA0162 SPT6H Homo sapiens (Human) TR40281_c2_g1_i1 Q0IEK6 EPG5_AEDAE 4.00E-13 GO:0006914 autophagy Ectopic P granules protein 5 homolog AAEL009648 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR40281_c4_g1_i1 A5WUT8 EPG5_DANRE 1.00E-30 GO:0006914 autophagy Ectopic P granules protein 5 homolog epg5 si:dkey-165i4.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR40281_c5_g1_i1 Q0IEK6 EPG5_AEDAE 4.00E-14 GO:0006914 autophagy Ectopic P granules protein 5 homolog AAEL009648 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR40281_c9_g2_i1 Q9HCE0 EPG5_HUMAN 4.00E-35 GO:0006914 autophagy Ectopic P granules protein 5 homolog EPG5 KIAA1632 Homo sapiens (Human) TR40281_c9_g2_i2 A5WUT8 EPG5_DANRE 9.00E-43 GO:0006914 autophagy Ectopic P granules protein 5 homolog epg5 si:dkey-165i4.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR40281_c9_g4_i1 A5WUT8 EPG5_DANRE 6.00E-34 GO:0006914 autophagy Ectopic P granules protein 5 homolog epg5 si:dkey-165i4.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR40283_c0_g2_i2 Q7ZU13 SPNS1_DANRE 7.00E-18 GO:0016021; GO:0006869; GO:0005743; GO:0055085 integral to membrane; lipid transport; mitochondrial inner membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Protein spinster homolog 1 (Protein not really started) (Spinster-like protein) spns1 nrs spinl Danio rerio (Zebrafish) (Brachydanio rerio) TR40283_c0_g2_i3 Q7ZU13 SPNS1_DANRE 6.00E-18 GO:0016021; GO:0006869; GO:0005743; GO:0055085 integral to membrane; lipid transport; mitochondrial inner membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Protein spinster homolog 1 (Protein not really started) (Spinster-like protein) spns1 nrs spinl Danio rerio (Zebrafish) (Brachydanio rerio) TR40284_c2_g1_i1 Q6UVM3 KCNT2_HUMAN 0 GO:0005524; GO:0015269; GO:0005249; GO:0008076 ATP binding; calcium-activated potassium channel activity; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR013099; IPR003929; IPR016040; Potassium channel subfamily T member 2 (Sequence like an intermediate conductance potassium channel subunit) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1) KCNT2 SLICK Homo sapiens (Human) TR40284_c2_g1_i4 Q8QFV0 KCNT1_CHICK 5.00E-108 GO:0015269; GO:0005249; GO:0008076 calcium-activated potassium channel activity; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR013099; IPR003929; IPR016040; Potassium channel subfamily T member 1 (Sequence like a calcium-activated potassium channel subunit) KCNT1 SLACK Gallus gallus (Chicken) TR40285_c0_g1_i1 Q6ZQ38 CAND1_MOUSE 0 GO:0010265; GO:0030154; GO:0031461; GO:0005737; GO:0043086; GO:0005634; GO:0045893; GO:0016567 "SCF complex assembly; cell differentiation; cullin-RING ubiquitin ligase complex; cytoplasm; negative regulation of catalytic activity; nucleus; positive regulation of transcription, DNA-dependent; protein ubiquitination" IPR011989; IPR016024; IPR013932; Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1) Cand1 D10Ertd516e Kiaa0829 Mus musculus (Mouse) TR40285_c0_g1_i4 Q6ZQ38 CAND1_MOUSE 0 GO:0010265; GO:0030154; GO:0031461; GO:0005737; GO:0043086; GO:0005634; GO:0045893; GO:0016567 "SCF complex assembly; cell differentiation; cullin-RING ubiquitin ligase complex; cytoplasm; negative regulation of catalytic activity; nucleus; positive regulation of transcription, DNA-dependent; protein ubiquitination" IPR011989; IPR016024; IPR013932; Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1) Cand1 D10Ertd516e Kiaa0829 Mus musculus (Mouse) TR40285_c0_g2_i6 Q6ZQ38 CAND1_MOUSE 2.00E-177 GO:0010265; GO:0030154; GO:0031461; GO:0005737; GO:0043086; GO:0005634; GO:0045893; GO:0016567 "SCF complex assembly; cell differentiation; cullin-RING ubiquitin ligase complex; cytoplasm; negative regulation of catalytic activity; nucleus; positive regulation of transcription, DNA-dependent; protein ubiquitination" IPR011989; IPR016024; IPR013932; Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1) Cand1 D10Ertd516e Kiaa0829 Mus musculus (Mouse) TR40286_c2_g2_i1 Q8TDX9 PK1L1_HUMAN 2.00E-63 GO:0005262; GO:0016337; GO:0005929; GO:0050982; GO:0003127; GO:0016021; GO:0070986; GO:0016020 calcium channel activity; cell-cell adhesion; cilium; detection of mechanical stimulus; detection of nodal flow; integral to membrane; left/right axis specification; membrane IPR008976; IPR022409; IPR002859; IPR013122; IPR000601; IPR001024; IPR014010; Polycystic kidney disease protein 1-like 1 (PC1-like 1 protein) (Polycystin-1L1) PKD1L1 UNQ5785/PRO19563 Homo sapiens (Human) TR40286_c3_g2_i1 Q4GZT3 PKD2_BOVIN 2.00E-42 GO:0007259; GO:0035904; GO:0045180; GO:0009925; GO:0001658; GO:0005262; GO:0005509; GO:0048763; GO:0007050; GO:0005911; GO:0071498; GO:0071464; GO:0071470; GO:0042994; GO:0050982; GO:0003127; GO:0071910; GO:0001892; GO:0031941; GO:0001947; GO:0071458; GO:0071556; GO:0005887; GO:0030027; GO:0016020; GO:0072177; GO:0072284; GO:0072218; GO:0072214; GO:0072219; GO:0072235; GO:0072075; GO:0035502; GO:0072208; GO:0005932; GO:0072686; GO:0031512; GO:2000134; GO:0060315; GO:0021915; GO:0031513; GO:0060674; GO:0002133; GO:0071158; GO:0031659; GO:0031587; GO:0045429; GO:0045944; GO:0005267; GO:0030814; GO:0090279; GO:0042127; GO:0051209; GO:0061441; GO:0061333; GO:0021510; GO:0005245; GO:0005248 "JAK-STAT cascade; aorta development; basal cortex; basal plasma membrane; branching involved in ureteric bud morphogenesis; calcium channel activity; calcium ion binding; calcium-induced calcium release activity; cell cycle arrest; cell-cell junction; cellular response to fluid shear stress; cellular response to hydrostatic pressure; cellular response to osmotic stress; cytoplasmic sequestering of transcription factor; detection of mechanical stimulus; detection of nodal flow; determination of liver left/right asymmetry; embryonic placenta development; filamentous actin; heart looping; integral to cytosolic side of endoplasmic reticulum membrane; integral to lumenal side of endoplasmic reticulum membrane; integral to plasma membrane; lamellipodium; membrane; mesonephric duct development; metanephric S-shaped body morphogenesis; metanephric ascending thin limb development; metanephric cortex development; metanephric cortical collecting duct development; metanephric distal tubule development; metanephric mesenchyme development; metanephric part of ureteric bud development; metanephric smooth muscle tissue development; microtubule basal body; mitotic spindle; motile primary cilium; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of ryanodine-sensitive calcium-release channel activity; neural tube development; nonmotile primary cilium; placenta blood vessel development; polycystin complex; positive regulation of cell cycle arrest; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; positive regulation of nitric oxide biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; potassium channel activity; regulation of cAMP metabolic process; regulation of calcium ion import; regulation of cell proliferation; release of sequestered calcium ion into cytosol; renal artery morphogenesis; renal tubule morphogenesis; spinal cord development; voltage-gated calcium channel activity; voltage-gated sodium channel activity" IPR027359; IPR011992; IPR002048; IPR013122; IPR003915; Polycystin-2 (Polycystic kidney disease 2 protein homolog) PKD2 Bos taurus (Bovine) TR40286_c5_g1_i1 Q8TDX9 PK1L1_HUMAN 7.00E-11 GO:0005262; GO:0016337; GO:0005929; GO:0050982; GO:0003127; GO:0016021; GO:0070986; GO:0016020 calcium channel activity; cell-cell adhesion; cilium; detection of mechanical stimulus; detection of nodal flow; integral to membrane; left/right axis specification; membrane IPR008976; IPR022409; IPR002859; IPR013122; IPR000601; IPR001024; IPR014010; Polycystic kidney disease protein 1-like 1 (PC1-like 1 protein) (Polycystin-1L1) PKD1L1 UNQ5785/PRO19563 Homo sapiens (Human) TR40287_c0_g1_i3 A4FV45 TM214_BOVIN 8.00E-75 GO:0006915; GO:0005881; GO:0005789; GO:0016021 apoptotic process; cytoplasmic microtubule; endoplasmic reticulum membrane; integral to membrane IPR019308; Transmembrane protein 214 TMEM214 Bos taurus (Bovine) TR40288_c4_g2_i1 P50533 SMC2_XENLA 2.00E-157 GO:0005524; GO:0006310; GO:0006281; GO:0051301; GO:0000796; GO:0005829; GO:0007076; GO:0005634; GO:0007062 ATP binding; DNA recombination; DNA repair; cell division; condensin complex; cytosol; mitotic chromosome condensation; nucleus; sister chromatid cohesion IPR027417; IPR003395; IPR024704; IPR027120; IPR010935; Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome assembly protein XCAP-E) (Chromosome-associated protein E) smc2 cape smc2l1 Xenopus laevis (African clawed frog) TR40288_c4_g2_i3 Q9C5Y4 SMC21_ARATH 3.00E-98 GO:0005524; GO:0006310; GO:0006281; GO:0051301; GO:0000796; GO:0007126; GO:0007076; GO:0005634; GO:0007062; GO:0005215 ATP binding; DNA recombination; DNA repair; cell division; condensin complex; meiosis; mitotic chromosome condensation; nucleus; sister chromatid cohesion; transporter activity IPR027417; IPR003395; IPR024704; IPR027120; IPR010935; Structural maintenance of chromosomes protein 2-1 (AtSMC2-1) (Chromosome-associated protein E-1) (AtCAP-E1) (Protein TITAN 3) SMC2-1 CAP-E1 TTN3 At5g62410 MMI9.19 MMI9.24 Arabidopsis thaliana (Mouse-ear cress) TR40288_c4_g2_i4 P50533 SMC2_XENLA 3.00E-28 GO:0005524; GO:0006310; GO:0006281; GO:0051301; GO:0000796; GO:0005829; GO:0007076; GO:0005634; GO:0007062 ATP binding; DNA recombination; DNA repair; cell division; condensin complex; cytosol; mitotic chromosome condensation; nucleus; sister chromatid cohesion IPR027417; IPR003395; IPR024704; IPR027120; IPR010935; Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome assembly protein XCAP-E) (Chromosome-associated protein E) smc2 cape smc2l1 Xenopus laevis (African clawed frog) TR40288_c4_g3_i1 O95347 SMC2_HUMAN 1.00E-40 GO:0005524; GO:0006310; GO:0006281; GO:0051301; GO:0000796; GO:0005829; GO:0051383; GO:0010032; GO:0045132; GO:0007076; GO:0000228; GO:0007062 Q15003; Q6IBW4; Q9NTJ3 ATP binding; DNA recombination; DNA repair; cell division; condensin complex; cytosol; kinetochore organization; meiotic chromosome condensation; meiotic chromosome segregation; mitotic chromosome condensation; nuclear chromosome; sister chromatid cohesion IPR027417; IPR003395; IPR024704; IPR027120; IPR010935; Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (hCAP-E) (XCAP-E homolog) SMC2 CAPE SMC2L1 PRO0324 Homo sapiens (Human) TR40289_c0_g2_i2 Q58HI1 PELP1_XENLA 5.00E-46 GO:0071339; GO:0005737; GO:0006351 "MLL1 complex; cytoplasm; transcription, DNA-dependent" IPR011989; IPR016024; IPR012980; "Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor)" pelp1 mnar Xenopus laevis (African clawed frog) TR40290_c0_g1_i1 Q9JIB0 MOG1_MOUSE 6.00E-37 GO:0008536; GO:0005087; GO:0005737; GO:0014704; GO:0006913; GO:0005654; GO:0015031; GO:0003254; GO:2000649; GO:0017080 Ran GTPase binding; Ran guanyl-nucleotide exchange factor activity; cytoplasm; intercalated disc; nucleocytoplasmic transport; nucleoplasm; protein transport; regulation of membrane depolarization; regulation of sodium ion transmembrane transporter activity; sodium channel regulator activity IPR007681; IPR016123; Ran guanine nucleotide release factor (RanGNRF) (Ran-binding protein MOG1) Rangrf Mog1 Rangnrf Mus musculus (Mouse) TR40290_c1_g1_i1 Q12767 K0195_HUMAN 2.00E-91 GO:0016021 integral to membrane IPR006068; IPR023298; Uncharacterized protein KIAA0195 (Transmembrane protein 94) KIAA0195 TMEM94 Homo sapiens (Human) TR40290_c1_g1_i2 Q12767 K0195_HUMAN 1.00E-50 GO:0016021 integral to membrane IPR006068; IPR023298; Uncharacterized protein KIAA0195 (Transmembrane protein 94) KIAA0195 TMEM94 Homo sapiens (Human) TR40291_c0_g1_i1 Q0VF22 CC138_MOUSE 8.00E-27 Coiled-coil domain-containing protein 138 Ccdc138 Mus musculus (Mouse) TR40291_c0_g2_i4 Q0VF22 CC138_MOUSE 1.00E-34 Coiled-coil domain-containing protein 138 Ccdc138 Mus musculus (Mouse) TR40292_c0_g2_i1 P48451 CANB1_DROME 6.00E-07 GO:0005955; GO:0005509; GO:0008597; GO:0005516; GO:0007269; GO:0051533; GO:0006470; GO:0030431; GO:0008021; GO:0016192 calcineurin complex; calcium ion binding; calcium-dependent protein serine/threonine phosphatase regulator activity; calmodulin binding; neurotransmitter secretion; positive regulation of NFAT protein import into nucleus; protein dephosphorylation; sleep; synaptic vesicle; vesicle-mediated transport IPR011992; IPR018247; IPR002048; Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) CanB CANB1 CNB CNB1 CG4209 Drosophila melanogaster (Fruit fly) TR40292_c0_g2_i2 Q8HYN7 KCIP4_MACFA 3.00E-85 GO:0005509; GO:0005886; GO:0005267; GO:0005244 calcium ion binding; plasma membrane; potassium channel activity; voltage-gated ion channel activity IPR011992; IPR018247; IPR002048; IPR001125; Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Potassium channel-interacting protein 4) KCNIP4 KCHIP4 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR40292_c0_g2_i3 P37236 FREQ_DROME 2.00E-51 GO:0005509; GO:0008048; GO:0016020; GO:0007528; GO:0007269; GO:0046928 calcium ion binding; calcium sensitive guanylate cyclase activator activity; membrane; neuromuscular junction development; neurotransmitter secretion; regulation of neurotransmitter secretion IPR011992; IPR018247; IPR002048; IPR001125; Frequenin-1 (d-FRQ) Frq1 Frq CG5744 Drosophila melanogaster (Fruit fly) TR40292_c0_g2_i4 Q568Z7 CIB2_RAT 8.00E-06 GO:0005509; GO:0055074; GO:0045494; GO:0001917 calcium ion binding; calcium ion homeostasis; photoreceptor cell maintenance; photoreceptor inner segment IPR011992; IPR018247; IPR002048; Calcium and integrin-binding family member 2 Cib2 Rattus norvegicus (Rat) TR40292_c0_g2_i6 Q43531 CCAMK_LILLO 2.00E-11 GO:0005524; GO:0005509; GO:0004683; GO:0016021 ATP binding; calcium ion binding; calmodulin-dependent protein kinase activity; integral to membrane IPR011992; IPR018247; IPR002048; IPR011009; IPR000719; IPR017441; IPR001125; IPR002290; IPR008271; Calcium and calcium/calmodulin-dependent serine/threonine-protein kinase (LlCCaMK) (EC 2.7.11.17) CCAMK Lilium longiflorum (Trumpet lily) TR40292_c0_g2_i7 Q99MG9 KCIP4_RAT 7.00E-85 GO:0005509; GO:0030425; GO:0016020; GO:0043025; GO:0005886; GO:0005267; GO:0005244 calcium ion binding; dendrite; membrane; neuronal cell body; plasma membrane; potassium channel activity; voltage-gated ion channel activity IPR011992; IPR018247; IPR002048; IPR001125; Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Potassium channel-interacting protein 4) Kcnip4 Kchip4 Rattus norvegicus (Rat) TR40292_c0_g2_i8 Q9QXT8 CSEN_MOUSE 9.00E-83 GO:0003677; GO:0005794; GO:0006915; GO:0048266; GO:0005509; GO:0005829; GO:0005783; GO:0000122; GO:0005634; GO:0005886; GO:0005267; GO:0006813; GO:0043523; GO:0019233; GO:0006351; GO:0005244 "DNA binding; Golgi apparatus; apoptotic process; behavioral response to pain; calcium ion binding; cytosol; endoplasmic reticulum; negative regulation of transcription from RNA polymerase II promoter; nucleus; plasma membrane; potassium channel activity; potassium ion transport; regulation of neuron apoptotic process; sensory perception of pain; transcription, DNA-dependent; voltage-gated ion channel activity" IPR011992; IPR018247; IPR002048; IPR001125; Calsenilin (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (KChIP3) Kcnip3 Csen Dream Kchip3 Mus musculus (Mouse) TR40293_c0_g1_i1 P04066 FUCO_HUMAN 5.00E-110 GO:0004560; GO:0042806; GO:0006004; GO:0006027; GO:0005764 alpha-L-fucosidase activity; fucose binding; fucose metabolic process; glycosaminoglycan catabolic process; lysosome IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) FUCA1 Nbla10230 Homo sapiens (Human) TR40293_c0_g1_i3 C3YWU0 FUCO_BRAFL 6.00E-116 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR40293_c0_g1_i4 Q99LJ1 FUCO_MOUSE 1.00E-108 GO:0004560; GO:0042806; GO:0006004; GO:0005764 alpha-L-fucosidase activity; fucose binding; fucose metabolic process; lysosome IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) Fuca1 Fuca Mus musculus (Mouse) TR40293_c0_g1_i6 Q9VTJ4 FUCO_DROME 1.00E-82 GO:0004560; GO:0042742; GO:0042806; GO:0006004; GO:0006027; GO:0005764 alpha-L-fucosidase activity; defense response to bacterium; fucose binding; fucose metabolic process; glycosaminoglycan catabolic process; lysosome IPR000933; IPR016286; IPR013781; IPR017853; Putative alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) Fuca CG6128 Drosophila melanogaster (Fruit fly) TR40293_c0_g2_i4 Q8GW72 FUCO1_ARATH 5.00E-07 GO:0004560; GO:0048046; GO:0005975; GO:0006516; GO:0005773 Q9ZPS9 alpha-L-fucosidase activity; apoplast; carbohydrate metabolic process; glycoprotein catabolic process; vacuole IPR008979; IPR000933; IPR013781; IPR017853; "Alpha-L-fucosidase 1 (EC 3.2.1.51) (Alpha-1,3/4-fucosidase) (AtFUC1) (Alpha-L-fucoside fucohydrolase)" FUC1 At2g28100 F24D13.11 Arabidopsis thaliana (Mouse-ear cress) TR40295_c4_g1_i1 Q54XA2 Y9099_DICDI 1.00E-26 GO:0035556 intracellular signal transduction IPR000591; IPR027244; IPR011991; DEP domain-containing protein DDB_G0279099 DDB_G0279099 Dictyostelium discoideum (Slime mold) TR40295_c5_g1_i1 O75140 DEPD5_HUMAN 1.00E-66 GO:0005096; GO:0005829; GO:0035556; GO:0005765; GO:0048471; GO:0043547 GTPase activator activity; cytosol; intracellular signal transduction; lysosomal membrane; perinuclear region of cytoplasm; positive regulation of GTPase activity IPR000591; IPR027244; IPR011991; DEP domain-containing protein 5 DEPDC5 KIAA0645 Homo sapiens (Human) TR40295_c5_g1_i2 O75140 DEPD5_HUMAN 1.00E-66 GO:0005096; GO:0005829; GO:0035556; GO:0005765; GO:0048471; GO:0043547 GTPase activator activity; cytosol; intracellular signal transduction; lysosomal membrane; perinuclear region of cytoplasm; positive regulation of GTPase activity IPR000591; IPR027244; IPR011991; DEP domain-containing protein 5 DEPDC5 KIAA0645 Homo sapiens (Human) TR40295_c5_g1_i4 Q6CWI2 IML1_KLULA 1.00E-21 GO:0035556; GO:0005774 intracellular signal transduction; vacuolar membrane IPR000591; IPR027244; IPR011991; Vacuolar membrane-associated protein IML1 IML1 KLLA0B03894g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR40296_c3_g3_i2 Q6AYR2 NDRG3_RAT 6.00E-89 IPR004142; Protein NDRG3 (N-myc downstream-regulated gene 3 protein) Ndrg3 Ndr3 Rattus norvegicus (Rat) TR40297_c1_g1_i1 Q0VGK3 GLCTK_RAT 7.00E-81 GO:0005524; GO:0005794; GO:0005737; GO:0008887; GO:0006468 ATP binding; Golgi apparatus; cytoplasm; glycerate kinase activity; protein phosphorylation IPR007835; IPR025286; Glycerate kinase (EC 2.7.1.31) Glyctk Rattus norvegicus (Rat) TR40298_c0_g2_i1 Q6DDT1 INO1B_XENLA 0 GO:0005737; GO:0006021; GO:0004512; GO:0008654 cytoplasm; inositol biosynthetic process; inositol-3-phosphate synthase activity; phospholipid biosynthetic process IPR002587; IPR013021; IPR016040; Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2. Inositol-3-phosphate synthase 1-B (IPS 1-B) (EC 5.5.1.4) (Myo-inositol 1-phosphate synthase B) (MI-1-P synthase B) (MIP synthase B) isyna1-b ino1-b Xenopus laevis (African clawed frog) TR40298_c0_g2_i2 Q9S7U0 INO1_WHEAT 0 GO:0005737; GO:0006021; GO:0004512; GO:0008654 cytoplasm; inositol biosynthetic process; inositol-3-phosphate synthase activity; phospholipid biosynthetic process IPR002587; IPR013021; IPR016040; Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2. Inositol-3-phosphate synthase (MIP synthase) (EC 5.5.1.4) (Myo-inositol 1-phosphate synthase) (IPS) (MI-1-P synthase) MIPS Triticum aestivum (Wheat) TR40299_c0_g2_i1 P17987 TCPA_HUMAN 0 GO:0051084; GO:0005524; GO:0005794; GO:0001669; GO:0007339; GO:0030054; GO:0005813; GO:0005832; GO:0005829; GO:0005874; GO:0005720; GO:0005634; GO:0000242; GO:0005886; GO:0007021; GO:0051082; GO:0002199 'de novo' posttranslational protein folding; ATP binding; Golgi apparatus; acrosomal vesicle; binding of sperm to zona pellucida; cell junction; centrosome; chaperonin-containing T-complex; cytosol; microtubule; nuclear heterochromatin; nucleus; pericentriolar material; plasma membrane; tubulin complex assembly; unfolded protein binding; zona pellucida receptor complex IPR012715; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) TCP1 CCT1 CCTA Homo sapiens (Human) TR4030_c0_g2_i1 P86179 CSL3_ONCKE 4.00E-07 GO:0030246 carbohydrate binding IPR000922; L-rhamnose-binding lectin CSL3 Oncorhynchus keta (Chum salmon) (Salmo keta) TR40300_c2_g3_i1 P17934 PA2A4_BUNMU 6.00E-14 GO:0005509; GO:0016042; GO:0072556; GO:0004623; GO:0006644 calcium ion binding; lipid catabolic process; other organism presynaptic membrane; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Acidic phospholipase A2 beta-bungarotoxin A4 chain (Beta-BuTX A4 chain) (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) Bungarus multicinctus (Many-banded krait) TR40300_c2_g3_i2 P08873 PA2B2_NOTSC 1.00E-15 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Basic phospholipase A2 notechis 11'2 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake) TR40300_c2_g3_i3 P00607 PA2H1_NOTSC 7.00E-15 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Basic phospholipase A2 homolog 1 (svPLA2 homolog) (Notechis II-1) Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake) TR40300_c2_g3_i5 F8QN54 PA2B_VIPRE 5.00E-14 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Basic phospholipase A2 vurtoxin (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) Vipera renardi (Steppe viper) (Vipera ursinii renardi) TR40300_c2_g3_i7 Q9PUH5 PA2B9_AUSSU 2.00E-15 GO:0005509; GO:0005576; GO:0016042; GO:0004623; GO:0006644 calcium ion binding; extracellular region; lipid catabolic process; phospholipase A2 activity; phospholipid metabolic process IPR001211; IPR013090; IPR016090; Basic phospholipase A2 S11-61 (svPLA2) (EC 3.1.1.4) (ASPLA9) (Phosphatidylcholine 2-acylhydrolase) Austrelaps superbus (Lowland copperhead snake) (Hoplocephalus superbus) TR40301_c1_g1_i3 Q9VCA9 SPCS3_DROME 3.00E-70 GO:0016021; GO:0008233; GO:0006508; GO:0005787; GO:0006465 integral to membrane; peptidase activity; proteolysis; signal peptidase complex; signal peptide processing IPR007653; Signal peptidase complex subunit 3 (EC 3.4.-.-) (Microsomal signal peptidase 22 kDa subunit) (SPC22) (SPase 22 kDa subunit) Spase22-23 CG5677 Drosophila melanogaster (Fruit fly) TR40302_c0_g1_i1 Q9NQX1 PRDM5_HUMAN 3.00E-31 GO:0051567; GO:0016575; GO:0046872; GO:0008168; GO:0000278; GO:0045892; GO:0005634; GO:0070491; GO:0043565; GO:0044212; GO:0000976; GO:0006351 Q96KQ7; Q99684; Q13547 "histone H3-K9 methylation; histone deacetylation; metal ion binding; methyltransferase activity; mitotic cell cycle; negative regulation of transcription, DNA-dependent; nucleus; repressing transcription factor binding; sequence-specific DNA binding; transcription regulatory region DNA binding; transcription regulatory region sequence-specific DNA binding; transcription, DNA-dependent" IPR001214; IPR007087; IPR015880; IPR013087; IPR022755; IPR017125; PR domain zinc finger protein 5 (EC 2.1.1.-) (PR domain-containing protein 5) PRDM5 PFM2 Homo sapiens (Human) TR40302_c0_g1_i10 A2VDW9 IKZF3_BOVIN 5.00E-15 GO:0042113; GO:0005737; GO:0046872; GO:0005634; GO:0046982; GO:0042803; GO:0045577; GO:0030888; GO:0042981; GO:0006355; GO:0043565; GO:0006351 "B cell activation; cytoplasm; metal ion binding; nucleus; protein heterodimerization activity; protein homodimerization activity; regulation of B cell differentiation; regulation of B cell proliferation; regulation of apoptotic process; regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein Aiolos (Ikaros family zinc finger protein 3) IKZF3 ZNFN1A3 Bos taurus (Bovine) TR40302_c0_g1_i2 P17022 ZNF18_HUMAN 2.00E-15 GO:0003677; GO:0046872; GO:0005634; GO:0000981 DNA binding; metal ion binding; nucleus; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR001909; IPR008916; IPR003309; IPR027764; IPR007087; IPR015880; IPR013087; Zinc finger protein 18 (Heart development-specific gene 1 protein) (Zinc finger protein 535) (Zinc finger protein KOX11) (Zinc finger protein with KRAB and SCAN domains 6) ZNF18 HDSG1 KOX11 ZKSCAN6 ZNF535 Homo sapiens (Human) TR40302_c0_g1_i3 Q9NQX1 PRDM5_HUMAN 3.00E-31 GO:0051567; GO:0016575; GO:0046872; GO:0008168; GO:0000278; GO:0045892; GO:0005634; GO:0070491; GO:0043565; GO:0044212; GO:0000976; GO:0006351 Q96KQ7; Q99684; Q13547 "histone H3-K9 methylation; histone deacetylation; metal ion binding; methyltransferase activity; mitotic cell cycle; negative regulation of transcription, DNA-dependent; nucleus; repressing transcription factor binding; sequence-specific DNA binding; transcription regulatory region DNA binding; transcription regulatory region sequence-specific DNA binding; transcription, DNA-dependent" IPR001214; IPR007087; IPR015880; IPR013087; IPR022755; IPR017125; PR domain zinc finger protein 5 (EC 2.1.1.-) (PR domain-containing protein 5) PRDM5 PFM2 Homo sapiens (Human) TR40302_c0_g1_i4 Q9UKT9 IKZF3_HUMAN 4.00E-15 GO:0042113; GO:0005737; GO:0007498; GO:0046872; GO:0005634; GO:0005886; GO:0046982; GO:0042803; GO:0045577; GO:0030888; GO:0042981; GO:0006357; GO:0043565; GO:0003700; GO:0006351 Q9BZS1 "B cell activation; cytoplasm; mesoderm development; metal ion binding; nucleus; plasma membrane; protein heterodimerization activity; protein homodimerization activity; regulation of B cell differentiation; regulation of B cell proliferation; regulation of apoptotic process; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein Aiolos (Ikaros family zinc finger protein 3) IKZF3 ZNFN1A3 Homo sapiens (Human) TR40302_c0_g1_i5 Q07230 ZSCA2_MOUSE 5.00E-30 GO:0003677; GO:0030154; GO:0046872; GO:0007275; GO:0005634; GO:0003700; GO:0007283; GO:0006351 "DNA binding; cell differentiation; metal ion binding; multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity; spermatogenesis; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29) (Zfp-29) Zscan2 Zfp-29 Zfp29 Mus musculus (Mouse) TR40302_c0_g1_i7 O08954 SNAI2_RAT 2.00E-10 GO:0007219; GO:0001078; GO:0003705; GO:0060070; GO:0060536; GO:0003273; GO:0071364; GO:0044344; GO:0071479; GO:0003682; GO:0005737; GO:0035921; GO:0009790; GO:0003198; GO:0060429; GO:0046872; GO:0043518; GO:2000811; GO:0090090; GO:0035414; GO:0006933; GO:1900387; GO:0032331; GO:1902230; GO:0010839; GO:2000647; GO:0000122; GO:0010957; GO:0070563; GO:0014032; GO:0000790; GO:0001649; GO:0060021; GO:0043473; GO:0030335; GO:0045600; GO:0035066; GO:0032642; GO:0045667; GO:2000810; GO:0007605; GO:0043565; GO:0050872 "Notch signaling pathway; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; canonical Wnt receptor signaling pathway; cartilage morphogenesis; cell migration involved in endocardial cushion formation; cellular response to epidermal growth factor stimulus; cellular response to fibroblast growth factor stimulus; cellular response to ionizing radiation; chromatin binding; cytoplasm; desmosome disassembly; embryo development; epithelial to mesenchymal transition involved in endocardial cushion formation; epithelium development; metal ion binding; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of anoikis; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of catenin import into nucleus; negative regulation of cell adhesion involved in substrate-bound cell migration; negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter; negative regulation of chondrocyte differentiation; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of keratinocyte proliferation; negative regulation of stem cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of vitamin D biosynthetic process; negative regulation of vitamin D receptor signaling pathway; neural crest cell development; nuclear chromatin; osteoblast differentiation; palate development; pigmentation; positive regulation of cell migration; positive regulation of fat cell differentiation; positive regulation of histone acetylation; regulation of chemokine production; regulation of osteoblast differentiation; regulation of tight junction assembly; sensory perception of sound; sequence-specific DNA binding; white fat cell differentiation" IPR007087; IPR015880; IPR013087; Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2) Snai2 Slug Slugh Rattus norvegicus (Rat) TR40302_c0_g1_i8 P17022 ZNF18_HUMAN 2.00E-15 GO:0003677; GO:0046872; GO:0005634; GO:0000981 DNA binding; metal ion binding; nucleus; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR001909; IPR008916; IPR003309; IPR027764; IPR007087; IPR015880; IPR013087; Zinc finger protein 18 (Heart development-specific gene 1 protein) (Zinc finger protein 535) (Zinc finger protein KOX11) (Zinc finger protein with KRAB and SCAN domains 6) ZNF18 HDSG1 KOX11 ZKSCAN6 ZNF535 Homo sapiens (Human) TR40302_c0_g1_i9 Q9NQX1 PRDM5_HUMAN 3.00E-31 GO:0051567; GO:0016575; GO:0046872; GO:0008168; GO:0000278; GO:0045892; GO:0005634; GO:0070491; GO:0043565; GO:0044212; GO:0000976; GO:0006351 Q96KQ7; Q99684; Q13547 "histone H3-K9 methylation; histone deacetylation; metal ion binding; methyltransferase activity; mitotic cell cycle; negative regulation of transcription, DNA-dependent; nucleus; repressing transcription factor binding; sequence-specific DNA binding; transcription regulatory region DNA binding; transcription regulatory region sequence-specific DNA binding; transcription, DNA-dependent" IPR001214; IPR007087; IPR015880; IPR013087; IPR022755; IPR017125; PR domain zinc finger protein 5 (EC 2.1.1.-) (PR domain-containing protein 5) PRDM5 PFM2 Homo sapiens (Human) TR40303_c4_g1_i1 Q8Q0U0 Y045_METMA 4.00E-22 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR40304_c1_g1_i2 Q8CI17 MB213_MOUSE 1.00E-11 IPR024810; IPR024802; Protein mab-21-like 3 Mab21L3 Mus musculus (Mouse) TR40304_c1_g1_i4 Q8CI17 MB213_MOUSE 9.00E-12 IPR024810; IPR024802; Protein mab-21-like 3 Mab21L3 Mus musculus (Mouse) TR40305_c0_g1_i1 Q69Z23 DYH17_MOUSE 0 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 17, axonemal (Axonemal beta dynein heavy chain 17) (Ciliary dynein heavy chain 17)" Dnah17 Dnahc17 Kiaa3028 Mus musculus (Mouse) TR40305_c0_g1_i2 P23098 DYHC_TRIGR 0 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein beta chain, ciliary" Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla) TR40305_c0_g5_i1 P23098 DYHC_TRIGR 0 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein beta chain, ciliary" Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla) TR40305_c0_g7_i1 Q63170 DYH7_RAT 0 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0005509; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; calcium ion binding; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR026983; IPR026979; IPR024743; IPR024317; IPR004273; IPR013602; IPR018247; IPR002048; IPR027417; "Dynein heavy chain 7, axonemal (Axonemal beta dynein heavy chain 7) (Axonemal dynein heavy chain b) (Ciliary dynein heavy chain 7) (Dynein-like protein 7)" Dnah7 Axob Dlp7 Rattus norvegicus (Rat) TR40305_c0_g7_i4 Q63170 DYH7_RAT 0 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0005509; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; calcium ion binding; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR026983; IPR026979; IPR024743; IPR024317; IPR004273; IPR013602; IPR018247; IPR002048; IPR027417; "Dynein heavy chain 7, axonemal (Axonemal beta dynein heavy chain 7) (Axonemal dynein heavy chain b) (Ciliary dynein heavy chain 7) (Dynein-like protein 7)" Dnah7 Axob Dlp7 Rattus norvegicus (Rat) TR40305_c2_g1_i1 O13290 DYHC_SCHPO 9.00E-10 GO:0005524; GO:0006200; GO:0016887; GO:0030437; GO:0030981; GO:0005868; GO:0005881; GO:0005829; GO:0030989; GO:0071686; GO:0000741; GO:0035974; GO:0008569; GO:0044732; GO:0000743; GO:0031134; GO:0007129 O42667 ATP binding; ATP catabolic process; ATPase activity; ascospore formation; cortical microtubule cytoskeleton; cytoplasmic dynein complex; cytoplasmic microtubule; cytosol; dynein-driven meiotic oscillatory nuclear movement; horsetail nucleus; karyogamy; meiotic spindle pole body; minus-end-directed microtubule motor activity; mitotic spindle pole body; nuclear migration involved in conjugation with cellular fusion; sister chromatid biorientation; synapsis IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain, cytoplasmic (Dynein heavy chain, cytosolic) (DYHC)" dhc1 SPAC1093.06c SPAC30C2.01c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40307_c0_g1_i1 Q9Y345 SC6A5_HUMAN 0 GO:0015375; GO:0016021; GO:0005328; GO:0005886; GO:0007268 glycine:sodium symporter activity; integral to membrane; neurotransmitter:sodium symporter activity; plasma membrane; synaptic transmission IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) TR40308_c4_g2_i1 Q8N398 VW5B2_HUMAN 7.00E-06 IPR013694; IPR002035; von Willebrand factor A domain-containing protein 5B2 VWA5B2 Homo sapiens (Human) TR40308_c4_g3_i1 O00534 VMA5A_HUMAN 6.00E-81 GO:0005634 nucleus IPR013694; IPR002035; von Willebrand factor A domain-containing protein 5A (Breast cancer suppressor candidate 1) (BCSC-1) (Loss of heterozygosity 11 chromosomal region 2 gene A protein) VWA5A BCSC1 LOH11CR2A Homo sapiens (Human) TR40309_c4_g1_i3 Q8MJV2 NPBW2_BOVIN 1.00E-13 GO:0016021; GO:0008188; GO:0007218; GO:0005886 integral to membrane; neuropeptide receptor activity; neuropeptide signaling pathway; plasma membrane IPR000276; IPR017452; IPR009150; IPR027349; Neuropeptides B/W receptor type 2 (G-protein coupled receptor 8) NPBWR2 GPR8 Bos taurus (Bovine) TR40309_c4_g1_i5 Q8MJV2 NPBW2_BOVIN 1.00E-13 GO:0016021; GO:0008188; GO:0007218; GO:0005886 integral to membrane; neuropeptide receptor activity; neuropeptide signaling pathway; plasma membrane IPR000276; IPR017452; IPR009150; IPR027349; Neuropeptides B/W receptor type 2 (G-protein coupled receptor 8) NPBWR2 GPR8 Bos taurus (Bovine) TR40310_c0_g2_i1 Q5UR67 YR617_MIMIV 7.00E-22 IPR012816; Uncharacterized protein R617 MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) TR40310_c0_g2_i3 P30176 YBIA_ECOLI 4.00E-07 GO:0006928 cellular component movement IPR012816; Swarming motility protein YbiA ybiA b0798 JW0783 Escherichia coli (strain K12) TR40310_c0_g2_i4 P30176 YBIA_ECOLI 2.00E-07 GO:0006928 cellular component movement IPR012816; Swarming motility protein YbiA ybiA b0798 JW0783 Escherichia coli (strain K12) TR40310_c0_g2_i5 Q5UR67 YR617_MIMIV 4.00E-22 IPR012816; Uncharacterized protein R617 MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) TR40312_c3_g1_i1 Q90705 EF2_CHICK 0 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; translation elongation factor activity IPR000795; IPR009022; IPR000640; IPR027417; IPR020568; IPR014721; IPR005225; IPR009000; IPR005517; IPR004161; Elongation factor 2 (EF-2) EEF2 Gallus gallus (Chicken) TR40313_c3_g1_i1 P35003 CTRL_HALRU 2.00E-06 GO:0005615; GO:0006508; GO:0004252 extracellular space; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Chymotrypsin-like serine proteinase (EC 3.4.21.-) Haliotis rufescens (California red abalone) TR40313_c4_g2_i1 P49579 ACHB_XENLA 5.00E-06 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit beta (Fragment) chrnb1 Xenopus laevis (African clawed frog) TR40313_c5_g2_i1 Q96GM8 TOE1_HUMAN 2.00E-93 GO:0046872; GO:0016607; GO:0003676; GO:0005730 P04637 metal ion binding; nuclear speck; nucleic acid binding; nucleolus IPR006941; IPR012337; IPR000571; Target of EGR1 protein 1 TOE1 Homo sapiens (Human) TR40313_c5_g3_i3 Q8N5B7 CERS5_HUMAN 7.00E-50 GO:0046513; GO:0005789; GO:0016021; GO:0031965; GO:0043565; GO:0003700; GO:0044281; GO:0050291 ceramide biosynthetic process; endoplasmic reticulum membrane; integral to membrane; nuclear membrane; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; small molecule metabolic process; sphingosine N-acyltransferase activity IPR001356; IPR009057; IPR016439; IPR006634; Lipid metabolism; sphingolipid metabolism. Ceramide synthase 5 (CerS5) (EC 2.3.1.24) (LAG1 longevity assurance homolog 5) CERS5 LASS5 Homo sapiens (Human) TR40313_c5_g3_i4 Q9D6J1 CERS4_MOUSE 8.00E-58 GO:0046513; GO:0005783; GO:0005789; GO:0016021; GO:0031965; GO:0043565; GO:0003700; GO:0050291 ceramide biosynthetic process; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nuclear membrane; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sphingosine N-acyltransferase activity IPR001356; IPR009057; IPR016439; IPR006634; Ceramide synthase 4 (CerS4) (LAG1 longevity assurance homolog 4) (Translocating chain-associating membrane protein homolog 1) (TRAM homolog 1) Cers4 Lass4 Trh1 Mus musculus (Mouse) TR40313_c5_g3_i6 Q9D6J1 CERS4_MOUSE 8.00E-58 GO:0046513; GO:0005783; GO:0005789; GO:0016021; GO:0031965; GO:0043565; GO:0003700; GO:0050291 ceramide biosynthetic process; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nuclear membrane; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sphingosine N-acyltransferase activity IPR001356; IPR009057; IPR016439; IPR006634; Ceramide synthase 4 (CerS4) (LAG1 longevity assurance homolog 4) (Translocating chain-associating membrane protein homolog 1) (TRAM homolog 1) Cers4 Lass4 Trh1 Mus musculus (Mouse) TR40313_c5_g3_i8 Q9D6K9 CERS5_MOUSE 7.00E-48 GO:0046513; GO:0005783; GO:0005789; GO:0016021; GO:0031965; GO:0043565; GO:0003700; GO:0050291 ceramide biosynthetic process; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nuclear membrane; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sphingosine N-acyltransferase activity IPR001356; IPR009057; IPR016439; IPR006634; Lipid metabolism; sphingolipid metabolism. Ceramide synthase 5 (CerS5) (EC 2.3.1.24) (LAG1 longevity assurance homolog 5) (Translocating chain-associating membrane protein homolog 4) (TRAM homolog 4) Cers5 Lass5 Trh4 Mus musculus (Mouse) TR40313_c5_g4_i1 P27169 PON1_HUMAN 3.00E-08 GO:0019439; GO:0004063; GO:0004064; GO:0005509; GO:0046395; GO:0008203; GO:0043231; GO:0046434; GO:0046470; GO:0005543; GO:0051099; GO:0010875; GO:0032411; GO:0042803; GO:0009605; GO:0009636; GO:0034366 aromatic compound catabolic process; aryldialkylphosphatase activity; arylesterase activity; calcium ion binding; carboxylic acid catabolic process; cholesterol metabolic process; intracellular membrane-bounded organelle; organophosphate catabolic process; phosphatidylcholine metabolic process; phospholipid binding; positive regulation of binding; positive regulation of cholesterol efflux; positive regulation of transporter activity; protein homodimerization activity; response to external stimulus; response to toxic substance; spherical high-density lipoprotein particle IPR011042; IPR002640; IPR008363; Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1) PON1 PON Homo sapiens (Human) TR40314_c0_g1_i1 Q921N7 TMM70_MOUSE 5.00E-17 GO:0032592; GO:0005743; GO:0033615 integral to mitochondrial membrane; mitochondrial inner membrane; mitochondrial proton-transporting ATP synthase complex assembly IPR009724; "Transmembrane protein 70, mitochondrial" Tmem70 Mus musculus (Mouse) TR40314_c2_g1_i1 Q6C880 SEC22_YARLI 1.00E-24 GO:0000139; GO:0005789; GO:0016021; GO:0015031; GO:0016192 Golgi membrane; endoplasmic reticulum membrane; integral to membrane; protein transport; vesicle-mediated transport IPR011012; IPR010908; IPR001388; Protein transport protein SEC22 SEC22 YALI0D21956g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR40314_c2_g1_i3 Q7SXP0 S22BB_DANRE 7.00E-52 GO:0000139; GO:0005789; GO:0033116; GO:0016021; GO:0015031; GO:0016192 Golgi membrane; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; protein transport; vesicle-mediated transport IPR011012; IPR010908; IPR001388; Vesicle-trafficking protein SEC22b-B (SEC22 vesicle-trafficking protein homolog B-B) sec22bb sec22l1b Danio rerio (Zebrafish) (Brachydanio rerio) TR40314_c2_g2_i1 Q96IW7 SC22A_HUMAN 8.00E-10 GO:0006888; GO:0005789; GO:0016021; GO:0015031; GO:0005215 ER to Golgi vesicle-mediated transport; endoplasmic reticulum membrane; integral to membrane; protein transport; transporter activity IPR011012; IPR010908; IPR027152; Vesicle-trafficking protein SEC22a (SEC22 vesicle-trafficking protein homolog A) (SEC22 vesicle-trafficking protein-like 2) SEC22A SEC22L2 Homo sapiens (Human) TR40317_c0_g2_i1 O16116 GST3_CAEEL 3.00E-30 GO:0004364 glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase 3 (EC 2.5.1.18) (CeGST3) (GST class-sigma) gst-3 K08F4.11 Caenorhabditis elegans TR40317_c0_g2_i4 P91252 GST6_CAEEL 3.00E-22 GO:0004364 glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Probable glutathione S-transferase 6 (EC 2.5.1.18) (GST class-sigma) gst-6 F11G11.3 Caenorhabditis elegans TR40317_c0_g2_i6 O16116 GST3_CAEEL 4.00E-30 GO:0004364 glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase 3 (EC 2.5.1.18) (CeGST3) (GST class-sigma) gst-3 K08F4.11 Caenorhabditis elegans TR40318_c3_g1_i1 B2RRL2 JERKL_MOUSE 7.00E-06 GO:0003677; GO:0005634 DNA binding; nucleus IPR004875; IPR009057; IPR006600; IPR007889; Jerky protein homolog-like Jrkl Mus musculus (Mouse) TR40318_c3_g1_i5 B2RRL2 JERKL_MOUSE 2.00E-06 GO:0003677; GO:0005634 DNA binding; nucleus IPR004875; IPR009057; IPR006600; IPR007889; Jerky protein homolog-like Jrkl Mus musculus (Mouse) TR40322_c4_g3_i2 Q09573 KCC3_CAEEL 7.00E-14 GO:0016021; GO:0006813; GO:0006814; GO:0015293 integral to membrane; potassium ion transport; sodium ion transport; symporter activity IPR004841; Sodium/chloride cotransporter 3 kcc-3 K02A2.3 Caenorhabditis elegans TR40322_c4_g3_i4 Q6A4L1 S12A8_XENLA 8.00E-110 GO:0016021; GO:0006813; GO:0015293 integral to membrane; potassium ion transport; symporter activity IPR004841; Solute carrier family 12 member 8 slc12a8 Xenopus laevis (African clawed frog) TR40323_c1_g1_i1 Q5R7D0 COX18_PONAB 4.00E-51 GO:0031305; GO:0051204; GO:0008565; GO:0008535 integral to mitochondrial inner membrane; protein insertion into mitochondrial membrane; protein transporter activity; respiratory chain complex IV assembly IPR001708; Mitochondrial inner membrane protein COX18 COX18 OXA1L2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40323_c1_g1_i2 Q3IK55 YIDC_PSEHT 1.00E-10 GO:0016021; GO:0005886; GO:0051205; GO:0015031 integral to membrane; plasma membrane; protein insertion into membrane; protein transport IPR019998; IPR028055; IPR028053; IPR001708; Membrane protein insertase YidC (Foldase YidC) (Membrane integrase YidC) (Membrane protein YidC) yidC PSHAa3022 Pseudoalteromonas haloplanktis (strain TAC 125) TR40324_c0_g1_i1 Q5ZMP6 AP2M1_CHICK 0 GO:0030131; GO:0005905; GO:0006886; GO:0008289; GO:0005739; GO:0005886; GO:0016192 clathrin adaptor complex; coated pit; intracellular protein transport; lipid binding; mitochondrion; plasma membrane; vesicle-mediated transport IPR022775; IPR001392; IPR008968; IPR018240; IPR011012; AP-2 complex subunit mu (AP-2 mu chain) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Mu2-adaptin) (Plasma membrane adaptor AP-2 50 kDa protein) AP2M1 RCJMB04_1h23 Gallus gallus (Chicken) TR40325_c0_g2_i1 O75182 SIN3B_HUMAN 6.00E-70 GO:0000805; GO:0001741; GO:0000806; GO:0030849; GO:0048738; GO:0044255; GO:0003682; GO:0005737; GO:0045892; GO:0005654; GO:0007519; GO:0044281; GO:0003714; GO:0006351 "X chromosome; XY body; Y chromosome; autosome; cardiac muscle tissue development; cellular lipid metabolic process; chromatin binding; cytoplasm; negative regulation of transcription, DNA-dependent; nucleoplasm; skeletal muscle tissue development; small molecule metabolic process; transcription corepressor activity; transcription, DNA-dependent" IPR013194; IPR003822; Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b) SIN3B KIAA0700 Homo sapiens (Human) TR40325_c0_g3_i1 Q60520 SIN3A_MOUSE 2.00E-90 GO:0003677; GO:0006260; GO:0001106; GO:0016580; GO:0002218; GO:0034613; GO:0071333; GO:0003682; GO:0001701; GO:0000776; GO:0043066; GO:1901675; GO:1900181; GO:2000678; GO:0005730; GO:0010971; GO:0031937; GO:0002230; GO:0045944; GO:0033558; GO:0051595; GO:0003700; GO:0005667; GO:0017053 Q1EHW4; O88574; P48432; Q8BR65; Q3URK3 DNA binding; DNA replication; RNA polymerase II transcription corepressor activity; Sin3 complex; activation of innate immune response; cellular protein localization; cellular response to glucose stimulus; chromatin binding; in utero embryonic development; kinetochore; negative regulation of apoptotic process; negative regulation of histone H3-K27 acetylation; negative regulation of protein localization to nucleus; negative regulation of transcription regulatory region DNA binding; nucleolus; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of chromatin silencing; positive regulation of defense response to virus by host; positive regulation of transcription from RNA polymerase II promoter; protein deacetylase activity; response to methylglyoxal; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcriptional repressor complex IPR013194; IPR003822; Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) Sin3a Kiaa4126 Mus musculus (Mouse) TR40325_c0_g4_i1 Q60520 SIN3A_MOUSE 0 GO:0003677; GO:0006260; GO:0001106; GO:0016580; GO:0002218; GO:0034613; GO:0071333; GO:0003682; GO:0001701; GO:0000776; GO:0043066; GO:1901675; GO:1900181; GO:2000678; GO:0005730; GO:0010971; GO:0031937; GO:0002230; GO:0045944; GO:0033558; GO:0051595; GO:0003700; GO:0005667; GO:0017053 Q1EHW4; O88574; P48432; Q8BR65; Q3URK3 DNA binding; DNA replication; RNA polymerase II transcription corepressor activity; Sin3 complex; activation of innate immune response; cellular protein localization; cellular response to glucose stimulus; chromatin binding; in utero embryonic development; kinetochore; negative regulation of apoptotic process; negative regulation of histone H3-K27 acetylation; negative regulation of protein localization to nucleus; negative regulation of transcription regulatory region DNA binding; nucleolus; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of chromatin silencing; positive regulation of defense response to virus by host; positive regulation of transcription from RNA polymerase II promoter; protein deacetylase activity; response to methylglyoxal; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcriptional repressor complex IPR013194; IPR003822; Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) Sin3a Kiaa4126 Mus musculus (Mouse) TR40325_c0_g4_i2 O75182 SIN3B_HUMAN 3.00E-154 GO:0000805; GO:0001741; GO:0000806; GO:0030849; GO:0048738; GO:0044255; GO:0003682; GO:0005737; GO:0045892; GO:0005654; GO:0007519; GO:0044281; GO:0003714; GO:0006351 "X chromosome; XY body; Y chromosome; autosome; cardiac muscle tissue development; cellular lipid metabolic process; chromatin binding; cytoplasm; negative regulation of transcription, DNA-dependent; nucleoplasm; skeletal muscle tissue development; small molecule metabolic process; transcription corepressor activity; transcription, DNA-dependent" IPR013194; IPR003822; Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b) SIN3B KIAA0700 Homo sapiens (Human) TR40328_c1_g2_i1 Q99571 P2RX4_HUMAN 2.00E-112 GO:0005524; GO:0097190; GO:0030054; GO:0005507; GO:0042118; GO:0004931; GO:0005887; GO:0005765; GO:0051899; GO:0010614; GO:0048471; GO:0010524; GO:0050850; GO:0045429; GO:0032308; GO:0042803; GO:0001614; GO:0005102; GO:0008217; GO:0055117; GO:0002028; GO:0055119; GO:0033198; GO:0034405; GO:0019233; GO:0001894; GO:0008270 ATP binding; apoptotic signaling pathway; cell junction; copper ion binding; endothelial cell activation; extracellular ATP-gated cation channel activity; integral to plasma membrane; lysosomal membrane; membrane depolarization; negative regulation of cardiac muscle hypertrophy; perinuclear region of cytoplasm; positive regulation of calcium ion transport into cytosol; positive regulation of calcium-mediated signaling; positive regulation of nitric oxide biosynthetic process; positive regulation of prostaglandin secretion; protein homodimerization activity; purinergic nucleotide receptor activity; receptor binding; regulation of blood pressure; regulation of cardiac muscle contraction; regulation of sodium ion transport; relaxation of cardiac muscle; response to ATP; response to fluid shear stress; sensory perception of pain; tissue homeostasis; zinc ion binding IPR003047; IPR027309; IPR001429; P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor) P2RX4 Homo sapiens (Human) TR40328_c1_g2_i10 Q553Y0 P2XC_DICDI 2.00E-06 GO:0005524; GO:0006812; GO:0031164; GO:0006971; GO:0016021; GO:0005216; GO:0001614; GO:0050848 ATP binding; cation transport; contractile vacuolar membrane; hypotonic response; integral to membrane; ion channel activity; purinergic nucleotide receptor activity; regulation of calcium-mediated signaling IPR001429; P2X receptor C (P2XC) p2xC DDB_G0275191 Dictyostelium discoideum (Slime mold) TR40328_c1_g2_i2 Q54JH4 P2XE_DICDI 2.00E-07 GO:0005524; GO:0031164; GO:0004931; GO:0006971; GO:0016021; GO:0001614; GO:0050848 ATP binding; contractile vacuolar membrane; extracellular ATP-gated cation channel activity; hypotonic response; integral to membrane; purinergic nucleotide receptor activity; regulation of calcium-mediated signaling IPR001429; P2X receptor E (P2XE) p2xE DDB_G0288061 Dictyostelium discoideum (Slime mold) TR40328_c1_g2_i3 Q99571 P2RX4_HUMAN 5.00E-115 GO:0005524; GO:0097190; GO:0030054; GO:0005507; GO:0042118; GO:0004931; GO:0005887; GO:0005765; GO:0051899; GO:0010614; GO:0048471; GO:0010524; GO:0050850; GO:0045429; GO:0032308; GO:0042803; GO:0001614; GO:0005102; GO:0008217; GO:0055117; GO:0002028; GO:0055119; GO:0033198; GO:0034405; GO:0019233; GO:0001894; GO:0008270 ATP binding; apoptotic signaling pathway; cell junction; copper ion binding; endothelial cell activation; extracellular ATP-gated cation channel activity; integral to plasma membrane; lysosomal membrane; membrane depolarization; negative regulation of cardiac muscle hypertrophy; perinuclear region of cytoplasm; positive regulation of calcium ion transport into cytosol; positive regulation of calcium-mediated signaling; positive regulation of nitric oxide biosynthetic process; positive regulation of prostaglandin secretion; protein homodimerization activity; purinergic nucleotide receptor activity; receptor binding; regulation of blood pressure; regulation of cardiac muscle contraction; regulation of sodium ion transport; relaxation of cardiac muscle; response to ATP; response to fluid shear stress; sensory perception of pain; tissue homeostasis; zinc ion binding IPR003047; IPR027309; IPR001429; P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor) P2RX4 Homo sapiens (Human) TR40328_c1_g2_i4 Q5E9U1 P2RX4_BOVIN 2.00E-103 GO:0005524; GO:0004931; GO:0016021; GO:0016020; GO:0001614 ATP binding; extracellular ATP-gated cation channel activity; integral to membrane; membrane; purinergic nucleotide receptor activity IPR003047; IPR027309; IPR001429; P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor) P2RX4 Bos taurus (Bovine) TR40328_c1_g2_i6 Q93086 P2RX5_HUMAN 3.00E-99 GO:0005524; GO:0004931; GO:0005887; GO:0007399; GO:0010524; GO:0050850; GO:0001614 ATP binding; extracellular ATP-gated cation channel activity; integral to plasma membrane; nervous system development; positive regulation of calcium ion transport into cytosol; positive regulation of calcium-mediated signaling; purinergic nucleotide receptor activity IPR003048; IPR027309; IPR001429; P2X purinoceptor 5 (P2X5) (ATP receptor) (Purinergic receptor) P2RX5 P2X5 Homo sapiens (Human) TR40328_c1_g2_i7 P51578 P2RX5_RAT 3.00E-100 GO:0005524; GO:0005525; GO:0008144; GO:0004931; GO:0016021; GO:0005886; GO:0051260; GO:0001614; GO:0019228; GO:0043416; GO:0048630; GO:0008270 ATP binding; GTP binding; drug binding; extracellular ATP-gated cation channel activity; integral to membrane; plasma membrane; protein homooligomerization; purinergic nucleotide receptor activity; regulation of action potential in neuron; regulation of skeletal muscle tissue regeneration; skeletal muscle tissue growth; zinc ion binding IPR003048; IPR027309; IPR001429; P2X purinoceptor 5 (P2X5) (ATP receptor) (Purinergic receptor) P2rx5 Rattus norvegicus (Rat) TR40332_c4_g1_i1 Q9V3D4 IDGF2_DROME 2.00E-17 GO:0005975; GO:0006032; GO:0004568; GO:0005576; GO:0007444; GO:0008084 Q9VCA2 carbohydrate metabolic process; chitin catabolic process; chitinase activity; extracellular region; imaginal disc development; imaginal disc growth factor receptor binding IPR011583; IPR001223; IPR013781; IPR017853; IPR015520; Chitinase-like protein Idgf2 (Imaginal disk growth factor protein 2) Idgf2 CG4475 Drosophila melanogaster (Fruit fly) TR40332_c5_g1_i1 Q9W303 IDGF4_DROME 2.00E-29 GO:0005975; GO:0006032; GO:0004568; GO:0005576; GO:0007444; GO:0008084 carbohydrate metabolic process; chitin catabolic process; chitinase activity; extracellular region; imaginal disc development; imaginal disc growth factor receptor binding IPR011583; IPR001223; IPR013781; IPR017853; IPR015520; Chitinase-like protein Idgf4 (Imaginal disk growth factor protein 4) Idgf4 CG1780 Drosophila melanogaster (Fruit fly) TR40332_c5_g1_i3 Q13231 CHIT1_HUMAN 3.00E-132 GO:0008061; GO:0006032; GO:0008843; GO:0005615; GO:0006955; GO:0005764; GO:0000272; GO:0009617 chitin binding; chitin catabolic process; endochitinase activity; extracellular space; immune response; lysosome; polysaccharide catabolic process; response to bacterium IPR002557; IPR011583; IPR001223; IPR001579; IPR013781; IPR017853; Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) CHIT1 Homo sapiens (Human) TR40332_c5_g1_i4 P20533 CHIA1_BACCI 4.00E-49 GO:0030246; GO:0006032; GO:0004568; GO:0005576; GO:0000272 carbohydrate binding; chitin catabolic process; chitinase activity; extracellular region; polysaccharide catabolic process IPR003610; IPR011583; IPR003961; IPR001223; IPR001579; IPR013781; IPR017853; IPR013783; Chitinase A1 (EC 3.2.1.14) chiA1 Bacillus circulans TR40333_c5_g2_i1 P51869 CP4F4_RAT 4.00E-131 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 4F4 (EC 1.14.14.1) (CYPIVF4) Cyp4f4 Rattus norvegicus (Rat) TR40333_c5_g6_i1 P51870 CP4F5_RAT 4.00E-118 GO:0070330; GO:0005789; GO:0020037; GO:0006954; GO:0005506; GO:0006691 aromatase activity; endoplasmic reticulum membrane; heme binding; inflammatory response; iron ion binding; leukotriene metabolic process IPR001128; IPR017972; IPR002403; Cytochrome P450 4F5 (EC 1.14.14.1) (CYPIVF5) Cyp4f5 Rattus norvegicus (Rat) TR40338_c0_g1_i4 Q9CZV5 ST65G_MOUSE 4.00E-51 GO:0030914; GO:0043966; GO:0004402; GO:0051457; GO:0006355; GO:0003713; GO:0006351 "STAGA complex; histone H3 acetylation; histone acetyltransferase activity; maintenance of protein location in nucleus; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent" IPR006565; STAGA complex 65 subunit gamma (SPTF-associated factor 65 gamma) (STAF65gamma) (Suppressor of Ty 7-like) Supt7l Mus musculus (Mouse) TR40339_c0_g2_i1 Q3SX44 DDAH2_BOVIN 1.00E-32 GO:0000052; GO:0016403; GO:0005739; GO:0045429 citrulline metabolic process; dimethylargininase activity; mitochondrion; positive regulation of nitric oxide biosynthetic process IPR003198; "N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 (DDAH-2) (Dimethylarginine dimethylaminohydrolase 2) (EC 3.5.3.18) (DDAHII) (Dimethylargininase-2)" DDAH2 Bos taurus (Bovine) TR40339_c0_g2_i10 O94760 DDAH1_HUMAN 2.00E-43 GO:0016597; GO:0006527; GO:0000052; GO:0016403; GO:0046872; GO:0005739; GO:0007263; GO:0045766; GO:0045429; GO:0003073 amino acid binding; arginine catabolic process; citrulline metabolic process; dimethylargininase activity; metal ion binding; mitochondrion; nitric oxide mediated signal transduction; positive regulation of angiogenesis; positive regulation of nitric oxide biosynthetic process; regulation of systemic arterial blood pressure IPR003198; "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) (Dimethylargininase-1)" DDAH1 DDAH Homo sapiens (Human) TR40339_c0_g2_i2 O94760 DDAH1_HUMAN 1.00E-45 GO:0016597; GO:0006527; GO:0000052; GO:0016403; GO:0046872; GO:0005739; GO:0007263; GO:0045766; GO:0045429; GO:0003073 amino acid binding; arginine catabolic process; citrulline metabolic process; dimethylargininase activity; metal ion binding; mitochondrion; nitric oxide mediated signal transduction; positive regulation of angiogenesis; positive regulation of nitric oxide biosynthetic process; regulation of systemic arterial blood pressure IPR003198; "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) (Dimethylargininase-1)" DDAH1 DDAH Homo sapiens (Human) TR40339_c0_g2_i4 Q3SX44 DDAH2_BOVIN 3.00E-32 GO:0000052; GO:0016403; GO:0005739; GO:0045429 citrulline metabolic process; dimethylargininase activity; mitochondrion; positive regulation of nitric oxide biosynthetic process IPR003198; "N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 (DDAH-2) (Dimethylarginine dimethylaminohydrolase 2) (EC 3.5.3.18) (DDAHII) (Dimethylargininase-2)" DDAH2 Bos taurus (Bovine) TR40339_c0_g2_i6 O94760 DDAH1_HUMAN 1.00E-45 GO:0016597; GO:0006527; GO:0000052; GO:0016403; GO:0046872; GO:0005739; GO:0007263; GO:0045766; GO:0045429; GO:0003073 amino acid binding; arginine catabolic process; citrulline metabolic process; dimethylargininase activity; metal ion binding; mitochondrion; nitric oxide mediated signal transduction; positive regulation of angiogenesis; positive regulation of nitric oxide biosynthetic process; regulation of systemic arterial blood pressure IPR003198; "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) (Dimethylargininase-1)" DDAH1 DDAH Homo sapiens (Human) TR40341_c3_g1_i4 O96006 ZBED1_HUMAN 1.00E-10 GO:0003677; GO:0046872; GO:0000228; GO:0004803 DNA binding; metal ion binding; nuclear chromosome; transposase activity IPR008906; IPR012337; IPR003656; Zinc finger BED domain-containing protein 1 (Putative Ac-like transposable element) (dREF homolog) ZBED1 ALTE DREF KIAA0785 TRAMP Homo sapiens (Human) TR40342_c1_g1_i1 O43301 HS12A_HUMAN 5.00E-64 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR40342_c1_g2_i7 Q96MM6 HS12B_HUMAN 4.00E-37 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR40344_c0_g1_i1 Q54YM7 TM2D2_DICDI 3.00E-06 GO:0016021 integral to membrane IPR007829; TM2 domain-containing protein DDB_G0278163 DDB_G0278163 Dictyostelium discoideum (Slime mold) TR40344_c0_g1_i6 Q54YM7 TM2D2_DICDI 1.00E-11 GO:0016021 integral to membrane IPR007829; TM2 domain-containing protein DDB_G0278163 DDB_G0278163 Dictyostelium discoideum (Slime mold) TR40344_c0_g2_i4 A9ULE9 DJC22_XENTR 2.00E-07 GO:0016021 integral to membrane IPR001623; IPR007829; DnaJ homolog subfamily C member 22 dnajc22 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40346_c1_g1_i1 Q5ZJU4 URM1_CHICK 1.00E-35 GO:0005737; GO:0034227; GO:0002098 cytoplasm; tRNA thio-modification; tRNA wobble uridine modification IPR012675; IPR016155; IPR015221; tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. Ubiquitin-related modifier 1 URM1 RCJMB04_15k18 Gallus gallus (Chicken) TR40346_c2_g1_i1 Q5ZLC6 ANR10_CHICK 5.00E-08 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 10 ANKRD10 RCJMB04_6l10 Gallus gallus (Chicken) TR40346_c3_g1_i1 B2RU33 POTEC_HUMAN 1.00E-08 IPR002110; IPR020683; "POTE ankyrin domain family member C (ANKRD26-like family B member 2) (Prostate, ovary, testis-expressed protein on chromosome 18) (POTE-18)" POTEC A26B2 POTE18 Homo sapiens (Human) TR40346_c3_g1_i2 P97570 PLPL9_RAT 8.00E-106 GO:0043008; GO:0047499; GO:0032049; GO:0005813; GO:0006935; GO:0005829; GO:0007204; GO:0016042; GO:0060135; GO:0007613; GO:0005743; GO:0051967; GO:0090238; GO:2000304; GO:0045921; GO:0035774; GO:0090037; GO:0001934; GO:0090200; GO:0045909; GO:1901339; GO:0034976; GO:0014832 "ATP-dependent protein binding; calcium-independent phospholipase A2 activity; cardiolipin biosynthetic process; centrosome; chemotaxis; cytosol; elevation of cytosolic calcium ion concentration; lipid catabolic process; maternal process involved in female pregnancy; memory; mitochondrial inner membrane; negative regulation of synaptic transmission, glutamatergic; positive regulation of arachidonic acid secretion; positive regulation of ceramide biosynthetic process; positive regulation of exocytosis; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of protein kinase C signaling cascade; positive regulation of protein phosphorylation; positive regulation of release of cytochrome c from mitochondria; positive regulation of vasodilation; regulation of store-operated calcium channel activity; response to endoplasmic reticulum stress; urinary bladder smooth muscle contraction" IPR016035; IPR002110; IPR020683; IPR002641; 85/88 kDa calcium-independent phospholipase A2 (CaI-PLA2) (EC 3.1.1.4) (Group VI phospholipase A2) (GVI PLA2) (Intracellular membrane-associated calcium-independent phospholipase A2 beta) (iPLA2-beta) (Patatin-like phospholipase domain-containing protein 9) (PNPLA9) Pla2g6 Pnpla9 Rattus norvegicus (Rat) TR40347_c0_g1_i4 P53817 PAG16_RAT 3.00E-14 GO:0052740; GO:0005737; GO:0005783; GO:0016021; GO:0016042; GO:0016020; GO:0045786; GO:0048471; GO:0008970; GO:0052739; GO:0004623; GO:0008654 1-acyl-2-lysophosphatidylserine acylhydrolase activity; cytoplasm; endoplasmic reticulum; integral to membrane; lipid catabolic process; membrane; negative regulation of cell cycle; perinuclear region of cytoplasm; phosphatidylcholine 1-acylhydrolase activity; phosphatidylserine 1-acylhydrolase activity; phospholipase A2 activity; phospholipid biosynthetic process IPR007053; HRAS-like suppressor 3 (HRSL3) (EC 3.1.1.32) (EC 3.1.1.4) (Group XVI phospholipase A1/A2) (H-rev 107 protein) Pla2g16 H-rev107 Hrasls3 Hrev107 Rattus norvegicus (Rat) TR40348_c1_g1_i1 P16901 POL_OMVVS 1.00E-07 GO:0003677; GO:0015074; GO:0006310; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004170; GO:0046080; GO:0075713; GO:0004533; GO:0090305; GO:0006508; GO:0004523; GO:0046718; GO:0008270 DNA binding; DNA integration; DNA recombination; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; dUTP diphosphatase activity; dUTP metabolic process; establishment of integrated proviral latency; exoribonuclease H activity; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; viral entry into host cell; zinc ion binding IPR001969; IPR008180; IPR001037; IPR001584; IPR017856; IPR003308; IPR018061; IPR001995; IPR021109; IPR012337; IPR002156; IPR000477; IPR010659; IPR010661; Pol polyprotein [Cleaved into: Protease (EC 3.4.23.-) (Retropepsin); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2); Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23); Integrase (IN)] pol Ovine maedi visna related virus (strain South Africa) (SA-OMVV) (Ovine lentivirus) TR40348_c1_g1_i4 P10394 POL4_DROME 4.00E-39 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR40349_c0_g2_i3 Q5RAS1 RRMJ3_PONAB 4.00E-119 GO:0001510; GO:0008168; GO:0005730; GO:0006364 RNA methylation; methyltransferase activity; nucleolus; rRNA processing IPR015507; IPR012920; IPR024576; IPR002877; pre-rRNA processing protein FTSJ3 (EC 2.1.1.-) (2'-O-ribose RNA methyltransferase SPB1 homolog) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3) FTSJ3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40350_c5_g4_i1 P52654 TF2AA_DROME 5.00E-30 GO:0001129; GO:0045944; GO:0005672 TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly; positive regulation of transcription from RNA polymerase II promoter; transcription factor TFIIA complex IPR009083; IPR004855; IPR013028; IPR009088; Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (dTFIIA-L) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p30 subunit); Transcription initiation factor IIA beta chain (TFIIA p20 subunit)] TfIIA-L CG5930 Drosophila melanogaster (Fruit fly) TR40353_c6_g4_i1 Q0VFM0 ZFPL1_XENTR 1.00E-84 GO:0005794; GO:0016021; GO:0016192; GO:0008270 Golgi apparatus; integral to membrane; vesicle-mediated transport; zinc ion binding IPR001841; IPR013083; Zinc finger protein-like 1 zfpl1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40353_c6_g4_i2 O95159 ZFPL1_HUMAN 2.00E-83 GO:0003677; GO:0005794; GO:0016021; GO:0005634; GO:0006355; GO:0016192; GO:0008270 "DNA binding; Golgi apparatus; integral to membrane; nucleus; regulation of transcription, DNA-dependent; vesicle-mediated transport; zinc ion binding" IPR001841; IPR013083; Zinc finger protein-like 1 (Zinc finger protein MCG4) ZFPL1 Homo sapiens (Human) TR40356_c5_g3_i4 Q98943 CASP2_CHICK 7.00E-35 GO:0006915; GO:0004197; GO:0005622; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; intracellular; proteolysis; regulation of apoptotic process IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) TR40356_c5_g3_i6 Q98943 CASP2_CHICK 6.00E-37 GO:0006915; GO:0004197; GO:0005622; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; intracellular; proteolysis; regulation of apoptotic process IPR001315; IPR017350; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) TR40356_c5_g3_i8 P42574 CASP3_HUMAN 4.00E-30 GO:0001782; GO:0043029; GO:0008635; GO:0006309; GO:0004190; GO:0045165; GO:0004861; GO:0004197; GO:0005829; GO:0008625; GO:0007507; GO:0035329; GO:0097193; GO:0008631; GO:0030216; GO:0005739; GO:0030889; GO:0046007; GO:0043066; GO:0045736; GO:0051402; GO:0048011; GO:0030264; GO:0005654; GO:0005886; GO:0043065; GO:0043525; GO:0016485; GO:0006508; GO:0001836; GO:0006974; GO:0009411; GO:0034612; GO:0009611; GO:0007605 Q9BYP7 B cell homeostasis; T cell homeostasis; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; apoptotic DNA fragmentation; aspartic-type endopeptidase activity; cell fate commitment; cyclin-dependent protein serine/threonine kinase inhibitor activity; cysteine-type endopeptidase activity; cytosol; extrinsic apoptotic signaling pathway via death domain receptors; heart development; hippo signaling cascade; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to oxidative stress; keratinocyte differentiation; mitochondrion; negative regulation of B cell proliferation; negative regulation of activated T cell proliferation; negative regulation of apoptotic process; negative regulation of cyclin-dependent protein serine/threonine kinase activity; neuron apoptotic process; neurotrophin TRK receptor signaling pathway; nuclear fragmentation involved in apoptotic nuclear change; nucleoplasm; plasma membrane; positive regulation of apoptotic process; positive regulation of neuron apoptotic process; protein processing; proteolysis; release of cytochrome c from mitochondria; response to DNA damage stimulus; response to UV; response to tumor necrosis factor; response to wounding; sensory perception of sound IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 CPP32 Homo sapiens (Human) TR40357_c0_g1_i2 Q58DG1 MYG1_BOVIN 6.00E-134 GO:0005739; GO:0005634 mitochondrion; nucleus IPR003226; "UPF0160 protein MYG1, mitochondrial" Bos taurus (Bovine) TR40359_c3_g2_i2 Q5E9C4 TBCD7_BOVIN 2.00E-72 GO:0005097; GO:0032862; GO:0016023; GO:0031410; GO:0032007; GO:0032851; GO:0031398; GO:0070848 Rab GTPase activator activity; activation of Rho GTPase activity; cytoplasmic membrane-bounded vesicle; cytoplasmic vesicle; negative regulation of TOR signaling cascade; positive regulation of Rab GTPase activity; positive regulation of protein ubiquitination; response to growth factor stimulus IPR000195; TBC1 domain family member 7 TBC1D7 Bos taurus (Bovine) TR40359_c3_g2_i6 Q5E9C4 TBCD7_BOVIN 3.00E-73 GO:0005097; GO:0032862; GO:0016023; GO:0031410; GO:0032007; GO:0032851; GO:0031398; GO:0070848 Rab GTPase activator activity; activation of Rho GTPase activity; cytoplasmic membrane-bounded vesicle; cytoplasmic vesicle; negative regulation of TOR signaling cascade; positive regulation of Rab GTPase activity; positive regulation of protein ubiquitination; response to growth factor stimulus IPR000195; TBC1 domain family member 7 TBC1D7 Bos taurus (Bovine) TR40361_c4_g2_i1 Q9Y3Q0 NALD2_HUMAN 2.00E-160 GO:0050129; GO:0004180; GO:0016805; GO:0008239; GO:0016021; GO:0046872; GO:0008237; GO:0042135; GO:0006508; GO:0008236 N-formylglutamate deformylase activity; carboxypeptidase activity; dipeptidase activity; dipeptidyl-peptidase activity; integral to membrane; metal ion binding; metallopeptidase activity; neurotransmitter catabolic process; proteolysis; serine-type peptidase activity IPR007484; IPR003137; IPR007365; N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) NAALAD2 Homo sapiens (Human) TR40362_c0_g1_i3 Q9Y5Z4 HEBP2_HUMAN 3.00E-29 GO:0005737; GO:0005739 cytoplasm; mitochondrion IPR011256; IPR006917; Heme-binding protein 2 (Placental protein 23) (PP23) (Protein SOUL) HEBP2 C6orf34 SOUL Homo sapiens (Human) TR40363_c1_g1_i1 Q9YCQ6 GLMS_AERPE 9.00E-38 GO:0030246; GO:0016051; GO:0005737; GO:0006541; GO:0004360 carbohydrate binding; carbohydrate biosynthetic process; cytoplasm; glutamine metabolic process; glutamine-fructose-6-phosphate transaminase (isomerizing) activity IPR017932; IPR005855; IPR001347; Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase) (GFAT) (Glucosamine-6-phosphate synthase) (Hexosephosphate aminotransferase) (L-glutamine--D-fructose-6-phosphate amidotransferase) glmS APE_1205.1 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) TR40363_c1_g1_i2 A2P2R3 YM084_YEAST 2.00E-61 GO:0006048; GO:0006541; GO:0004360 UDP-N-acetylglucosamine biosynthetic process; glutamine metabolic process; glutamine-fructose-6-phosphate transaminase (isomerizing) activity IPR017932; Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1. Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing] (GFAT) (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase) (Hexosephosphate aminotransferase) YMR084W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40363_c1_g1_i3 Q9Z2Z9 GFPT2_MOUSE 0 GO:0006048; GO:0030246; GO:0016051; GO:0006541; GO:0004360 UDP-N-acetylglucosamine biosynthetic process; carbohydrate binding; carbohydrate biosynthetic process; glutamine metabolic process; glutamine-fructose-6-phosphate transaminase (isomerizing) activity IPR017932; IPR000583; IPR005855; IPR001347; Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1. Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 2) (Glutamine:fructose-6-phosphate amidotransferase 2) (GFAT 2) (GFAT2) (Hexosephosphate aminotransferase 2) Gfpt2 Mus musculus (Mouse) TR40363_c1_g2_i4 Q88BX8 GLMS_PSEPK 3.00E-55 GO:0030246; GO:0016051; GO:0005737; GO:0006541; GO:0004360 carbohydrate binding; carbohydrate biosynthetic process; cytoplasm; glutamine metabolic process; glutamine-fructose-6-phosphate transaminase (isomerizing) activity IPR017932; IPR005855; IPR001347; Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase) (GFAT) (Glucosamine-6-phosphate synthase) (Hexosephosphate aminotransferase) (L-glutamine--D-fructose-6-phosphate amidotransferase) glmS PP_5409 Pseudomonas putida (strain KT2440) TR40363_c1_g2_i5 Q8KG38 GLMS_CHLTE 2.00E-74 GO:0030246; GO:0016051; GO:0005737; GO:0006541; GO:0004360 carbohydrate binding; carbohydrate biosynthetic process; cytoplasm; glutamine metabolic process; glutamine-fructose-6-phosphate transaminase (isomerizing) activity IPR017932; IPR005855; IPR001347; Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase) (GFAT) (Glucosamine-6-phosphate synthase) (Hexosephosphate aminotransferase) (L-glutamine--D-fructose-6-phosphate amidotransferase) glmS CT0130 Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS) TR40363_c1_g2_i6 Q56206 GLMS_SPHYA 1.00E-37 GO:0030246; GO:0016051; GO:0005737; GO:0006541; GO:0004360 carbohydrate binding; carbohydrate biosynthetic process; cytoplasm; glutamine metabolic process; glutamine-fructose-6-phosphate transaminase (isomerizing) activity IPR005855; IPR001347; Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase) (GFAT) (Glucosamine-6-phosphate synthase) (Hexosephosphate aminotransferase) (L-glutamine--D-fructose-6-phosphate amidotransferase) (Fragment) glmS Sphingobium yanoikuyae (Sphingomonas yanoikuyae) TR40363_c1_g2_i7 O32157 FRLB_BACSU 7.00E-07 GO:0030246; GO:0005975; GO:0016787 carbohydrate binding; carbohydrate metabolic process; hydrolase activity IPR024713; IPR001347; Fructosamine deglycase FrlB (EC 3.5.-.-) frlB yurP BSU32610 Bacillus subtilis (strain 168) TR40364_c0_g1_i2 Q08DD7 SNX11_BOVIN 4.00E-20 GO:0007154; GO:0005768; GO:0016020; GO:1901981; GO:0015031; GO:0016050 cell communication; endosome; membrane; phosphatidylinositol phosphate binding; protein transport; vesicle organization IPR001683; Sorting nexin-11 SNX11 Bos taurus (Bovine) TR40364_c0_g1_i6 Q9ERE3 SGK3_MOUSE 2.00E-07 GO:0005524; GO:0007154; GO:0016023; GO:0005769; GO:2001240; GO:0035091; GO:0004674; GO:0055037 ATP binding; cell communication; cytoplasmic membrane-bounded vesicle; early endosome; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; phosphatidylinositol binding; protein serine/threonine kinase activity; recycling endosome IPR000961; IPR011009; IPR001683; IPR017892; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Cytokine-independent survival kinase) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like) Sgk3 Cisk Sgkl Mus musculus (Mouse) TR40364_c0_g1_i8 Q08DD7 SNX11_BOVIN 3.00E-21 GO:0007154; GO:0005768; GO:0016020; GO:1901981; GO:0015031; GO:0016050 cell communication; endosome; membrane; phosphatidylinositol phosphate binding; protein transport; vesicle organization IPR001683; Sorting nexin-11 SNX11 Bos taurus (Bovine) TR40365_c2_g2_i1 Q8TE73 DYH5_HUMAN 0 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 5, axonemal (Axonemal beta dynein heavy chain 5) (Ciliary dynein heavy chain 5)" DNAH5 DNAHC5 HL1 KIAA1603 Homo sapiens (Human) TR40365_c3_g1_i1 Q3V0Q1 DYH12_MOUSE 2.00E-29 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018; GO:0016567 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement; protein ubiquitination IPR003593; IPR011704; IPR026983; IPR024317; IPR004273; IPR013602; IPR027417; Protein modification; protein ubiquitination. "Dynein heavy chain 12, axonemal (Axonemal beta dynein heavy chain 12) (Axonemal dynein heavy chain 12-like protein) (Axonemal dynein heavy chain 7-like protein) (Ciliary dynein heavy chain 12)" Dnah12 Dnah12l Dnah7l Dnahc12 Dnahc7l Mus musculus (Mouse) TR40365_c3_g2_i1 Q0VDD8 DYH14_HUMAN 2.00E-36 GO:0005524; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR026983; IPR024743; IPR024317; IPR004273; IPR027417; "Dynein heavy chain 14, axonemal (Axonemal beta dynein heavy chain 14) (Ciliary dynein heavy chain 14)" DNAH14 C1orf67 Homo sapiens (Human) TR40365_c4_g1_i1 Q96JB1 DYH8_HUMAN 0 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 8, axonemal (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8)" DNAH8 Homo sapiens (Human) TR40368_c0_g1_i1 Q8K2D0 F199X_MOUSE 2.00E-21 Protein FAM199X Fam199x Mus musculus (Mouse) TR40369_c0_g1_i1 Q5JVL4 EFHC1_HUMAN 0 GO:0005930; GO:0005509; GO:0005929; GO:0043025; GO:0008022 axoneme; calcium ion binding; cilium; neuronal cell body; protein C-terminus binding IPR010554; IPR011992; IPR002048; IPR006602; EF-hand domain-containing protein 1 (Myoclonin-1) EFHC1 Homo sapiens (Human) TR40370_c0_g2_i1 Q96N67 DOCK7_HUMAN 0 GO:0048365; GO:0032863; GO:0030424; GO:0007409; GO:0045178; GO:0045200; GO:0030426; GO:0005085; GO:0000226; GO:0043473; GO:0033138; GO:0007264 Rac GTPase binding; activation of Rac GTPase activity; axon; axonogenesis; basal part of cell; establishment of neuroblast polarity; growth cone; guanyl-nucleotide exchange factor activity; microtubule cytoskeleton organization; pigmentation; positive regulation of peptidyl-serine phosphorylation; small GTPase mediated signal transduction IPR027007; IPR027357; IPR026791; IPR010703; IPR021816; Dedicator of cytokinesis protein 7 DOCK7 KIAA1771 Homo sapiens (Human) TR40370_c1_g1_i1 P59764 DOCK4_MOUSE 1.00E-09 GO:0030675; GO:0060326; GO:0005829; GO:0012505; GO:0005085; GO:0016020; GO:0007264; GO:0032420 Rac GTPase activator activity; cell chemotaxis; cytosol; endomembrane system; guanyl-nucleotide exchange factor activity; membrane; small GTPase mediated signal transduction; stereocilium IPR027007; IPR027357; IPR026791; IPR026800; IPR010703; IPR011511; IPR001452; Dedicator of cytokinesis protein 4 Dock4 Kiaa0716 Mus musculus (Mouse) TR40370_c1_g1_i2 Q96HP0 DOCK6_HUMAN 2.00E-128 GO:0007596; GO:0005829; GO:0005085; GO:0048471; GO:0007264 blood coagulation; cytosol; guanyl-nucleotide exchange factor activity; perinuclear region of cytoplasm; small GTPase mediated signal transduction IPR027007; IPR027357; IPR026791; IPR026798; IPR010703; IPR021816; Dedicator of cytokinesis protein 6 DOCK6 KIAA1395 Homo sapiens (Human) TR40370_c1_g2_i1 Q96N67 DOCK7_HUMAN 0 GO:0048365; GO:0032863; GO:0030424; GO:0007409; GO:0045178; GO:0045200; GO:0030426; GO:0005085; GO:0000226; GO:0043473; GO:0033138; GO:0007264 Rac GTPase binding; activation of Rac GTPase activity; axon; axonogenesis; basal part of cell; establishment of neuroblast polarity; growth cone; guanyl-nucleotide exchange factor activity; microtubule cytoskeleton organization; pigmentation; positive regulation of peptidyl-serine phosphorylation; small GTPase mediated signal transduction IPR027007; IPR027357; IPR026791; IPR010703; IPR021816; Dedicator of cytokinesis protein 7 DOCK7 KIAA1771 Homo sapiens (Human) TR40370_c1_g2_i2 Q5JSL3 DOC11_HUMAN 4.00E-51 GO:0005089; GO:0007596; GO:0005829; GO:0005543; GO:0007264 Rho guanyl-nucleotide exchange factor activity; blood coagulation; cytosol; phospholipid binding; small GTPase mediated signal transduction IPR016024; IPR027007; IPR027357; IPR026791; IPR010703; IPR021816; IPR026796; IPR011993; IPR001849; Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) DOCK11 ZIZ2 Homo sapiens (Human) TR40372_c2_g1_i2 Q9H0A8 COMD4_HUMAN 2.00E-63 GO:0005737 Q8N668 cytoplasm IPR017920; IPR009886; COMM domain-containing protein 4 COMMD4 Homo sapiens (Human) TR40377_c2_g2_i4 A7RM45 LMBD1_NEMVE 4.00E-19 GO:0031419; GO:0016021; GO:0005765; GO:0006810 cobalamin binding; integral to membrane; lysosomal membrane; transport IPR006876; Probable lysosomal cobalamin transporter v1g160387 Nematostella vectensis (Starlet sea anemone) TR40379_c0_g1_i1 P41214 EIF2D_HUMAN 2.00E-120 GO:0005737; GO:0006886; GO:0004872; GO:0003743 cytoplasm; intracellular protein transport; receptor activity; translation initiation factor activity IPR002478; IPR015947; IPR003121; IPR001950; Eukaryotic translation initiation factor 2D (eIF2d) (Hepatocellular carcinoma-associated antigen 56) (Ligatin) EIF2D HCA56 LGTN Homo sapiens (Human) TR40379_c0_g1_i3 P0CL18 EIF2D_RABIT 5.00E-62 GO:0005737; GO:0003743 cytoplasm; translation initiation factor activity IPR002478; IPR015947; IPR003121; IPR001950; IPR004521; Eukaryotic translation initiation factor 2D (eIF2d) (Ligatin) EIF2D LGTN Oryctolagus cuniculus (Rabbit) TR40380_c3_g1_i1 Q8SSJ5 CDC48_ENCCU 2.00E-40 GO:0005524; GO:0007049; GO:0005783; GO:0017111; GO:0015031 ATP binding; cell cycle; endoplasmic reticulum; nucleoside-triphosphatase activity; protein transport IPR003593; IPR009010; IPR003959; IPR003960; IPR003338; IPR027417; Cell division control protein 48 CDC48 ECU01_1230 Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) TR40380_c3_g1_i2 O28972 Y1297_ARCFU 4.00E-58 GO:0005524; GO:0017111 ATP binding; nucleoside-triphosphatase activity IPR003593; IPR005938; IPR009010; IPR003959; IPR003960; IPR004201; IPR003338; IPR027417; IPR015415; Cell division cycle protein 48 homolog AF_1297 AF_1297 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) TR40380_c3_g1_i4 P54351 NSF2_DROME 0 GO:0005524; GO:0005737; GO:0046872; GO:0007274; GO:0017111; GO:0015031; GO:0008582; GO:0016082 ATP binding; cytoplasm; metal ion binding; neuromuscular synaptic transmission; nucleoside-triphosphatase activity; protein transport; regulation of synaptic growth at neuromuscular junction; synaptic vesicle priming IPR003593; IPR009010; IPR003959; IPR003960; IPR004201; IPR003338; IPR027417; Vesicle-fusing ATPase 2 (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein 2) (NEM-sensitive fusion protein 2) (Vesicular-fusion protein NSF2) (dNsf-2) (NSF-2) Nsf2 CG33101 Drosophila melanogaster (Fruit fly) TR40382_c3_g2_i1 Q3V1M1 IGS10_MOUSE 9.00E-14 GO:0005576; GO:0001503 extracellular region; ossification IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Immunoglobulin superfamily member 10 (IgSF10) Igsf10 Mus musculus (Mouse) TR40382_c3_g2_i2 Q62838 MUSK_RAT 9.00E-20 GO:0005524; GO:0030154; GO:0030054; GO:0042995; GO:0090102; GO:0009897; GO:0016021; GO:0060291; GO:0007613; GO:0010629; GO:0031594; GO:0007528; GO:0010628; GO:0050731; GO:0045887; GO:0032224; GO:0045211; GO:0046777; GO:0004713; GO:0043113; GO:0048678; GO:0051602; GO:0014850; GO:0060041; GO:0004714 "ATP binding; cell differentiation; cell junction; cell projection; cochlea development; external side of plasma membrane; integral to membrane; long-term synaptic potentiation; memory; negative regulation of gene expression; neuromuscular junction; neuromuscular junction development; positive regulation of gene expression; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of synaptic growth at neuromuscular junction; positive regulation of synaptic transmission, cholinergic; postsynaptic membrane; protein autophosphorylation; protein tyrosine kinase activity; receptor clustering; response to axon injury; response to electrical stimulus; response to muscle activity; retina development in camera-type eye; transmembrane receptor protein tyrosine kinase activity" IPR020067; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; "Muscle, skeletal receptor tyrosine protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)" Musk Rattus norvegicus (Rat) TR40382_c3_g3_i1 Q868Z9 PPN_DROME 4.00E-35 GO:0005604; GO:0030198; GO:0005201; GO:0004222; GO:0007275; GO:0004867; GO:0008270 basement membrane; extracellular matrix organization; extracellular matrix structural constituent; metalloendopeptidase activity; multicellular organismal development; serine-type endopeptidase inhibitor activity; zinc ion binding IPR010294; IPR007110; IPR013783; IPR013098; IPR003598; IPR013273; IPR010909; IPR002223; IPR020901; IPR000884; IPR008197; Papilin Ppn CG33103 Drosophila melanogaster (Fruit fly) TR40382_c3_g3_i2 Q868Z9 PPN_DROME 3.00E-35 GO:0005604; GO:0030198; GO:0005201; GO:0004222; GO:0007275; GO:0004867; GO:0008270 basement membrane; extracellular matrix organization; extracellular matrix structural constituent; metalloendopeptidase activity; multicellular organismal development; serine-type endopeptidase inhibitor activity; zinc ion binding IPR010294; IPR007110; IPR013783; IPR013098; IPR003598; IPR013273; IPR010909; IPR002223; IPR020901; IPR000884; IPR008197; Papilin Ppn CG33103 Drosophila melanogaster (Fruit fly) TR40382_c3_g3_i3 Q7TQN3 WFKN2_MOUSE 1.00E-15 GO:0005576; GO:0008191; GO:0004867; GO:0007179 extracellular region; metalloendopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity; transforming growth factor beta receptor signaling pathway IPR007110; IPR013783; IPR013098; IPR003598; IPR002350; IPR001134; IPR018933; IPR002223; IPR020901; IPR008993; IPR008197; "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 (Growth and differentiation factor-associated serum protein 1) (GASP-1) (mGASP-1)" Wfikkn2 Gasp1 Mus musculus (Mouse) TR40382_c3_g3_i5 Q8WPI2 BOOH2_BOOMI 4.00E-18 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Boophilin-H2 H2 Rhipicephalus microplus (Cattle tick) (Boophilus microplus) TR40382_c3_g4_i1 Q868Z9 PPN_DROME 7.00E-82 GO:0005604; GO:0030198; GO:0005201; GO:0004222; GO:0007275; GO:0004867; GO:0008270 basement membrane; extracellular matrix organization; extracellular matrix structural constituent; metalloendopeptidase activity; multicellular organismal development; serine-type endopeptidase inhibitor activity; zinc ion binding IPR010294; IPR007110; IPR013783; IPR013098; IPR003598; IPR013273; IPR010909; IPR002223; IPR020901; IPR000884; IPR008197; Papilin Ppn CG33103 Drosophila melanogaster (Fruit fly) TR40382_c3_g4_i2 P19761 TFPI1_RABIT 9.00E-29 GO:0007596; GO:0005576; GO:0004867 blood coagulation; extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR008296; IPR020901; Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI) TFPI Oryctolagus cuniculus (Rabbit) TR40386_c0_g1_i1 Q6PDL0 DC1L2_MOUSE 8.00E-148 GO:0005524; GO:0005813; GO:0051642; GO:0005868; GO:0005874; GO:0000226; GO:0003777; GO:0007018; GO:0006810 ATP binding; centrosome; centrosome localization; cytoplasmic dynein complex; microtubule; microtubule cytoskeleton organization; microtubule motor activity; microtubule-based movement; transport IPR008467; IPR022780; IPR027417; "Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic)" Dync1li2 Dncli2 Dnclic2 Mus musculus (Mouse) TR40386_c0_g1_i3 Q6AY43 DC2L1_RAT 7.00E-07 GO:0045177; GO:0042384; GO:0035085; GO:0007368; GO:0030286; GO:0030990; GO:0005874; GO:0031512; GO:0003774 apical part of cell; cilium assembly; cilium axoneme; determination of left/right symmetry; dynein complex; intraflagellar transport particle; microtubule; motile primary cilium; motor activity IPR022780; IPR027417; Cytoplasmic dynein 2 light intermediate chain 1 Dync2li1 Lic3 Rattus norvegicus (Rat) TR40387_c3_g1_i1 Q9I8M9 TWS1B_XENLA 1.00E-18 GO:0005576; GO:0007275 extracellular region; multicellular organismal development IPR006761; Twisted gastrulation protein homolog 1-B twsg1-b tsg Xenopus laevis (African clawed frog) TR40389_c2_g1_i1 A5HNF6 MYD88_CHICK 3.00E-42 GO:0002755; GO:0035419; GO:0005829; GO:0050830; GO:0016064; GO:0006954; GO:0045087; GO:0031663; GO:0044130; GO:0005634; GO:0005886; GO:0043123; GO:0046330; GO:0042346; GO:0051092; GO:0045080; GO:0032740; GO:0032747; GO:0032755; GO:0050671; GO:0032760; GO:0050727; GO:0002238; GO:0032494; GO:0009615; GO:0035681; GO:0034134; GO:0035682; GO:0034142; GO:0034146; GO:0034154; GO:0045351 MyD88-dependent toll-like receptor signaling pathway; activation of MAPK activity involved in innate immune response; cytosol; defense response to Gram-positive bacterium; immunoglobulin mediated immune response; inflammatory response; innate immune response; lipopolysaccharide-mediated signaling pathway; negative regulation of growth of symbiont in host; nucleus; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; positive regulation of NF-kappaB import into nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of chemokine biosynthetic process; positive regulation of interleukin-17 production; positive regulation of interleukin-23 production; positive regulation of interleukin-6 production; positive regulation of lymphocyte proliferation; positive regulation of tumor necrosis factor production; regulation of inflammatory response; response to molecule of fungal origin; response to peptidoglycan; response to virus; toll-like receptor 15 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 21 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 7 signaling pathway; type I interferon biosynthetic process IPR011029; IPR000488; IPR017281; IPR000157; Myeloid differentiation primary response protein MyD88 MYD88 RCJMB04_14h3 Gallus gallus (Chicken) TR40389_c2_g1_i3 Q5XJ85 MYD88_DANRE 2.00E-36 GO:0002755; GO:0002218; GO:0005737; GO:0006954; GO:0045087; GO:0043123; GO:0002237 MyD88-dependent toll-like receptor signaling pathway; activation of innate immune response; cytoplasm; inflammatory response; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; response to molecule of bacterial origin IPR011029; IPR000488; IPR017281; IPR000157; Myeloid differentiation primary response protein MyD88 myd88 Danio rerio (Zebrafish) (Brachydanio rerio) TR40390_c2_g1_i4 Q10138 YAS2_SCHPO 3.00E-24 GO:0005737; GO:0071852; GO:0008526 cytoplasm; fungal-type cell wall organization or biogenesis; phosphatidylinositol transporter activity IPR001251; IPR011074; CRAL-TRIO domain-containing protein C3H8.02 SPAC3H8.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40390_c2_g1_i5 Q9CWP6 MSPD2_MOUSE 8.00E-88 GO:0016021; GO:0005198 integral to membrane; structural molecule activity IPR001251; IPR011074; IPR000535; IPR008962; Motile sperm domain-containing protein 2 Mospd2 Mus musculus (Mouse) TR40390_c2_g1_i6 Q9CWP6 MSPD2_MOUSE 8.00E-88 GO:0016021; GO:0005198 integral to membrane; structural molecule activity IPR001251; IPR011074; IPR000535; IPR008962; Motile sperm domain-containing protein 2 Mospd2 Mus musculus (Mouse) TR40390_c2_g2_i1 Q96PH1 NOX5_HUMAN 4.00E-24 GO:0050661; GO:0001525; GO:0006915; GO:0005509; GO:0050663; GO:0000910; GO:0005783; GO:0001935; GO:0050660; GO:0020037; GO:0015252; GO:0016021; GO:2000379; GO:0043012; GO:0010155; GO:0042554; GO:0016175 P62157 NADP binding; angiogenesis; apoptotic process; calcium ion binding; cytokine secretion; cytokinesis; endoplasmic reticulum; endothelial cell proliferation; flavin adenine dinucleotide binding; heme binding; hydrogen ion channel activity; integral to membrane; positive regulation of reactive oxygen species metabolic process; regulation of fusion of sperm to egg plasma membrane; regulation of proton transport; superoxide anion generation; superoxide-generating NADPH oxidase activity IPR011992; IPR018247; IPR002048; IPR013112; IPR017927; IPR013130; IPR013121; IPR017938; NADPH oxidase 5 (EC 1.6.3.-) NOX5 Homo sapiens (Human) TR40390_c3_g1_i1 Q6CGE6 CANB_YARLI 3.00E-06 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calcineurin subunit B (Calcineurin regulatory subunit) (Protein phosphatase 2B regulatory subunit) CNB1 YALI0A19976g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR40392_c0_g1_i1 Q68ED7 CRTC1_MOUSE 3.00E-34 GO:0008140; GO:0005737; GO:0005634; GO:0032793; GO:0045944; GO:0051289; GO:0006351 "cAMP response element binding protein binding; cytoplasm; nucleus; positive regulation of CREB transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein homotetramerization; transcription, DNA-dependent" IPR024786; IPR024785; IPR024784; IPR024783; CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1 homolog) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) Crtc1 Kiaa0616 Mect1 Torc1 Mus musculus (Mouse) TR40392_c0_g2_i1 Q68ED7 CRTC1_MOUSE 1.00E-58 GO:0008140; GO:0005737; GO:0005634; GO:0032793; GO:0045944; GO:0051289; GO:0006351 "cAMP response element binding protein binding; cytoplasm; nucleus; positive regulation of CREB transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein homotetramerization; transcription, DNA-dependent" IPR024786; IPR024785; IPR024784; IPR024783; CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1 homolog) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) Crtc1 Kiaa0616 Mect1 Torc1 Mus musculus (Mouse) TR40392_c6_g1_i1 Q15435 PP1R7_HUMAN 3.00E-107 GO:0005737; GO:0005634; GO:0008599 cytoplasm; nucleus; protein phosphatase type 1 regulator activity IPR001611; IPR025875; IPR027733; IPR003603; Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22) PPP1R7 SDS22 Homo sapiens (Human) TR40392_c6_g1_i2 Q7Z7A1 CNTRL_HUMAN 1.00E-09 GO:0000086; GO:0051301; GO:0005813; GO:0005829 G2/M transition of mitotic cell cycle; cell division; centrosome; cytosol IPR001611; Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110) CNTRL CEP1 CEP110 Homo sapiens (Human) TR40392_c7_g1_i1 Q8R1Z9 RN121_MOUSE 9.00E-142 GO:0016021; GO:0008270 integral to membrane; zinc ion binding IPR001841; IPR013083; RING finger protein 121 Rnf121 Mus musculus (Mouse) TR40392_c7_g1_i3 Q8R1Z9 RN121_MOUSE 5.00E-140 GO:0016021; GO:0008270 integral to membrane; zinc ion binding IPR001841; IPR013083; RING finger protein 121 Rnf121 Mus musculus (Mouse) TR40395_c0_g1_i1 Q6DGV7 M17L2_DANRE 5.00E-37 GO:0016021 integral to membrane IPR007248; Mpv17-like protein 2 mpv17l2 zgc:92754 Danio rerio (Zebrafish) (Brachydanio rerio) TR40396_c1_g1_i1 O75628 REM1_HUMAN 7.00E-17 GO:0005525; GO:0003924; GO:0016020; GO:0007264 GTP binding; GTPase activity; membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR017358; IPR020849; GTP-binding protein REM 1 (GTPase-regulating endothelial cell sprouting) (Rad and Gem-like GTP-binding protein 1) REM1 GES REM Homo sapiens (Human) TR40396_c1_g1_i2 Q9CR56 KBRS2_MOUSE 8.00E-07 GO:0005525; GO:0003924; GO:0005737; GO:0016020; GO:0007264 GTP binding; GTPase activity; cytoplasm; membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; NF-kappa-B inhibitor-interacting Ras-like protein 2 (I-kappa-B-interacting Ras-like protein 2) (Kappa B-Ras protein 2) (KappaB-Ras2) Nkiras2 Mus musculus (Mouse) TR40396_c1_g1_i3 O35929 REM1_MOUSE 2.00E-21 GO:0005525; GO:0003924; GO:0016020; GO:0007264 GTP binding; GTPase activity; membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR017358; IPR020849; GTP-binding protein REM 1 (Rad and Gem-like GTP-binding protein 1) Rem1 Rem Mus musculus (Mouse) TR40398_c0_g1_i1 B8N7Z0 AGALD_ASPFN 6.00E-34 GO:0005576; GO:0000272; GO:0052692 extracellular region; polysaccharide catabolic process; raffinose alpha-galactosidase activity IPR013785; IPR013780; IPR002241; IPR000111; IPR017853; Probable alpha-galactosidase D (EC 3.2.1.22) (Melibiase D) aglD AFLA_105840 Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167) TR40398_c0_g1_i2 Q90744 NAGAB_CHICK 3.00E-143 GO:0008456; GO:0005975; GO:0005764 alpha-N-acetylgalactosaminidase activity; carbohydrate metabolic process; lysosome IPR013785; IPR013780; IPR002241; IPR000111; IPR017853; Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B) NAGA Gallus gallus (Chicken) TR40398_c0_g1_i3 Q9QWR8 NAGAB_MOUSE 1.00E-137 GO:0008456; GO:0004557; GO:0016052; GO:0005737; GO:0016139; GO:0046477; GO:0005764; GO:0009311 alpha-N-acetylgalactosaminidase activity; alpha-galactosidase activity; carbohydrate catabolic process; cytoplasm; glycoside catabolic process; glycosylceramide catabolic process; lysosome; oligosaccharide metabolic process IPR013785; IPR013780; IPR002241; IPR000111; IPR017853; Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B) Naga Mus musculus (Mouse) TR40398_c0_g1_i5 Q66H12 NAGAB_RAT 1.00E-135 GO:0008456; GO:0004557; GO:0016052; GO:0005737; GO:0016139; GO:0046477; GO:0005764; GO:0009311 alpha-N-acetylgalactosaminidase activity; alpha-galactosidase activity; carbohydrate catabolic process; cytoplasm; glycoside catabolic process; glycosylceramide catabolic process; lysosome; oligosaccharide metabolic process IPR013785; IPR013780; IPR002241; IPR000111; IPR017853; Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B) Naga Rattus norvegicus (Rat) TR40398_c0_g1_i8 A1D0A3 AGALB_NEOFI 4.00E-31 GO:0005975; GO:0005576; GO:0052692 carbohydrate metabolic process; extracellular region; raffinose alpha-galactosidase activity IPR013785; IPR013780; IPR002241; IPR000111; IPR017853; Probable alpha-galactosidase B (EC 3.2.1.22) (Melibiase B) aglB NFIA_039990 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) TR40400_c0_g1_i3 Q53G44 IF44L_HUMAN 2.00E-57 GO:0005737; GO:0051607; GO:0006955 cytoplasm; defense response to virus; immune response IPR024644; IPR027417; Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) TR40400_c0_g1_i4 Q8BV66 IFI44_MOUSE 9.00E-44 GO:0005737 cytoplasm IPR024644; IPR027417; IPR006571; Interferon-induced protein 44 (Microtubule-associated protein 44) Ifi44 Mtap44 Mus musculus (Mouse) TR40400_c0_g1_i5 Q53G44 IF44L_HUMAN 4.00E-58 GO:0005737; GO:0051607; GO:0006955 cytoplasm; defense response to virus; immune response IPR024644; IPR027417; Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) TR40400_c0_g1_i6 Q9BDB7 IF44L_MOUSE 3.00E-48 GO:0005737; GO:0006955 cytoplasm; immune response IPR024644; IPR027417; Interferon-induced protein 44-like [Cleaved into: Minor histocompatibility antigen HA-28 (HLA-HA28) (IFL8)] Ifi44l H28 Mus musculus (Mouse) TR40401_c0_g1_i1 Q9H0J9 PAR12_HUMAN 2.00E-21 GO:0003950; GO:0046872; GO:0005634 NAD+ ADP-ribosyltransferase activity; metal ion binding; nucleus IPR012317; IPR004170; IPR000571; Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) TR40401_c1_g1_i1 Q7Z2W4 ZCCHV_HUMAN 5.00E-09 GO:0005794; GO:0003950; GO:0003723; GO:0071360; GO:0005737; GO:0051607; GO:0045087; GO:0046872; GO:0045071; GO:0005634; GO:0005886; GO:0043123; GO:1900246; GO:0032727; GO:0032728; GO:0061014; GO:0032481; GO:0009615 O95786 Golgi apparatus; NAD+ ADP-ribosyltransferase activity; RNA binding; cellular response to exogenous dsRNA; cytoplasm; defense response to virus; innate immune response; metal ion binding; negative regulation of viral genome replication; nucleus; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of RIG-I signaling pathway; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of mRNA catabolic process; positive regulation of type I interferon production; response to virus IPR012317; IPR004170; IPR000571; Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) ZC3HAV1 ZC3HDC2 PRO1677 Homo sapiens (Human) TR40401_c1_g1_i2 Q9H0J9 PAR12_HUMAN 2.00E-11 GO:0003950; GO:0046872; GO:0005634 NAD+ ADP-ribosyltransferase activity; metal ion binding; nucleus IPR012317; IPR004170; IPR000571; Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) TR40401_c1_g1_i3 Q8C1B2 PARPT_MOUSE 3.00E-11 GO:0003950; GO:0008209; GO:0008210; GO:0060325; GO:0008585; GO:0030097; GO:0001822; GO:0046872; GO:0044236; GO:0006807; GO:0060021; GO:0048008; GO:0009791; GO:0006471; GO:0048705; GO:0048745; GO:0001570 NAD+ ADP-ribosyltransferase activity; androgen metabolic process; estrogen metabolic process; face morphogenesis; female gonad development; hemopoiesis; kidney development; metal ion binding; multicellular organismal metabolic process; nitrogen compound metabolic process; palate development; platelet-derived growth factor receptor signaling pathway; post-embryonic development; protein ADP-ribosylation; skeletal system morphogenesis; smooth muscle tissue development; vasculogenesis IPR012317; IPR004170; IPR000571; TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) Tiparp Mus musculus (Mouse) TR40401_c2_g2_i1 P13216 ADX_CHICK 1.00E-24 GO:0051537; GO:0008203; GO:0009055; GO:0042446; GO:0046872; GO:0005759; GO:0055114; GO:0006694 "2 iron, 2 sulfur cluster binding; cholesterol metabolic process; electron carrier activity; hormone biosynthetic process; metal ion binding; mitochondrial matrix; oxidation-reduction process; steroid biosynthetic process" IPR001041; IPR001055; IPR018298; IPR012675; "Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Fragment)" FDX1 Gallus gallus (Chicken) TR40401_c2_g2_i11 P13216 ADX_CHICK 7.00E-36 GO:0051537; GO:0008203; GO:0009055; GO:0042446; GO:0046872; GO:0005759; GO:0055114; GO:0006694 "2 iron, 2 sulfur cluster binding; cholesterol metabolic process; electron carrier activity; hormone biosynthetic process; metal ion binding; mitochondrial matrix; oxidation-reduction process; steroid biosynthetic process" IPR001041; IPR001055; IPR018298; IPR012675; "Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Fragment)" FDX1 Gallus gallus (Chicken) TR40401_c2_g2_i5 P13216 ADX_CHICK 2.00E-35 GO:0051537; GO:0008203; GO:0009055; GO:0042446; GO:0046872; GO:0005759; GO:0055114; GO:0006694 "2 iron, 2 sulfur cluster binding; cholesterol metabolic process; electron carrier activity; hormone biosynthetic process; metal ion binding; mitochondrial matrix; oxidation-reduction process; steroid biosynthetic process" IPR001041; IPR001055; IPR018298; IPR012675; "Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Fragment)" FDX1 Gallus gallus (Chicken) TR40401_c2_g2_i8 P00258 ADX_PIG 1.00E-33 GO:0051537; GO:0008203; GO:0009055; GO:0042446; GO:0046872; GO:0005759; GO:0055114; GO:0006694 "2 iron, 2 sulfur cluster binding; cholesterol metabolic process; electron carrier activity; hormone biosynthetic process; metal ion binding; mitochondrial matrix; oxidation-reduction process; steroid biosynthetic process" IPR001041; IPR001055; IPR018298; IPR012675; "Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Ferredoxin-1)" FDX1 Sus scrofa (Pig) TR40405_c1_g2_i2 Q16UN6 NCBP1_AEDAE 0 GO:0006370; GO:0000339; GO:0031047; GO:0045292; GO:0051028; GO:0005846; GO:0005634 "7-methylguanosine mRNA capping; RNA cap binding; gene silencing by RNA; mRNA cis splicing, via spliceosome; mRNA transport; nuclear cap binding complex; nucleus" IPR016024; IPR027159; IPR016021; IPR015172; IPR015174; IPR003890; Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit) Cbp80 AAEL009839 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR40405_c1_g4_i1 Q55D17 NCBP1_DICDI 2.00E-33 GO:0006370; GO:0000339; GO:0031047; GO:0045292; GO:0000398; GO:0051028; GO:0005846; GO:0005634 "7-methylguanosine mRNA capping; RNA cap binding; gene silencing by RNA; mRNA cis splicing, via spliceosome; mRNA splicing, via spliceosome; mRNA transport; nuclear cap binding complex; nucleus" IPR016024; IPR027159; IPR016021; IPR015172; IPR015174; IPR003890; Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit) ncbp1 cbp80 DDB_G0269814 Dictyostelium discoideum (Slime mold) TR40406_c0_g1_i1 Q9UK39 NOCT_HUMAN 2.00E-82 GO:0000932; GO:0033962; GO:0000290; GO:0005654; GO:0048511; GO:0003700; GO:0006366 cytoplasmic mRNA processing body; cytoplasmic mRNA processing body assembly; deadenylation-dependent decapping of nuclear-transcribed mRNA; nucleoplasm; rhythmic process; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter IPR005135; Nocturnin (EC 3.1.13.4) (Carbon catabolite repression 4-like protein) (Circadian deadenylase NOC) CCRN4L CCR4 NOC Homo sapiens (Human) TR40406_c0_g1_i2 Q9UK39 NOCT_HUMAN 1.00E-82 GO:0000932; GO:0033962; GO:0000290; GO:0005654; GO:0048511; GO:0003700; GO:0006366 cytoplasmic mRNA processing body; cytoplasmic mRNA processing body assembly; deadenylation-dependent decapping of nuclear-transcribed mRNA; nucleoplasm; rhythmic process; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter IPR005135; Nocturnin (EC 3.1.13.4) (Carbon catabolite repression 4-like protein) (Circadian deadenylase NOC) CCRN4L CCR4 NOC Homo sapiens (Human) TR40406_c0_g1_i3 Q0U7W4 CCR4_PHANO 2.00E-15 GO:0003723; GO:0005737; GO:0046872; GO:0090305; GO:0005634; GO:0004535; GO:0006355; GO:0006351 "RNA binding; cytoplasm; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleus; poly(A)-specific ribonuclease activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR005135; IPR001611; Glucose-repressible alcohol dehydrogenase transcriptional effector (EC 3.1.13.4) (Carbon catabolite repressor protein 4) (Cytoplasmic deadenylase) CCR4 SNOG_12150 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum) TR40406_c0_g1_i4 P79942 NOCT_XENLA 8.00E-85 GO:0048511 rhythmic process IPR005135; Nocturnin (EC 3.1.13.4) (Carbon catabolite repression 4-like protein) (Circadian deadenylase NOC) (Rhythmic message 1) (RM1) ccrn4l Xenopus laevis (African clawed frog) TR40407_c0_g1_i1 P07814 SYEP_HUMAN 0 GO:0005524; GO:0035613; GO:0071346; GO:0005829; GO:0004818; GO:0006424; GO:0017148; GO:0004827; GO:0006433; GO:0006461; GO:0030529; GO:0006418 P41252 ATP binding; RNA stem-loop binding; cellular response to interferon-gamma; cytosol; glutamate-tRNA ligase activity; glutamyl-tRNA aminoacylation; negative regulation of translation; proline-tRNA ligase activity; prolyl-tRNA aminoacylation; protein complex assembly; ribonucleoprotein complex; tRNA aminoacylation for protein translation IPR002314; IPR001412; IPR006195; IPR004154; IPR004526; IPR000924; IPR020061; IPR020058; IPR020059; IPR010987; IPR004499; IPR016061; IPR017449; IPR020056; IPR011035; IPR014729; IPR009068; IPR000738; Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] EPRS GLNS PARS QARS QPRS PIG32 Homo sapiens (Human) TR40407_c0_g1_i3 P07814 SYEP_HUMAN 2.00E-51 GO:0005524; GO:0035613; GO:0071346; GO:0005829; GO:0004818; GO:0006424; GO:0017148; GO:0004827; GO:0006433; GO:0006461; GO:0030529; GO:0006418 P41252 ATP binding; RNA stem-loop binding; cellular response to interferon-gamma; cytosol; glutamate-tRNA ligase activity; glutamyl-tRNA aminoacylation; negative regulation of translation; proline-tRNA ligase activity; prolyl-tRNA aminoacylation; protein complex assembly; ribonucleoprotein complex; tRNA aminoacylation for protein translation IPR002314; IPR001412; IPR006195; IPR004154; IPR004526; IPR000924; IPR020061; IPR020058; IPR020059; IPR010987; IPR004499; IPR016061; IPR017449; IPR020056; IPR011035; IPR014729; IPR009068; IPR000738; Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] EPRS GLNS PARS QARS QPRS PIG32 Homo sapiens (Human) TR40409_c3_g1_i1 Q6PFL8 THYN1_DANRE 8.00E-80 GO:0005634 nucleus IPR002740; IPR015947; Thymocyte nuclear protein 1 thyn1 zgc:66269 Danio rerio (Zebrafish) (Brachydanio rerio) TR40410_c1_g1_i1 Q5R4I9 DDX5_PONAB 4.00E-29 GO:0005524; GO:0008026; GO:0003723; GO:0003724; GO:0008380; GO:0050681; GO:0030331; GO:0072332; GO:0006397; GO:0000122; GO:0005730; GO:0043517; GO:0045944; GO:0000381; GO:0060765; GO:0045667; GO:2001014; GO:0005681; GO:0003713; GO:0006351 "ATP binding; ATP-dependent helicase activity; RNA binding; RNA helicase activity; RNA splicing; androgen receptor binding; estrogen receptor binding; intrinsic apoptotic signaling pathway by p53 class mediator; mRNA processing; negative regulation of transcription from RNA polymerase II promoter; nucleolus; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of transcription from RNA polymerase II promoter; regulation of alternative mRNA splicing, via spliceosome; regulation of androgen receptor signaling pathway; regulation of osteoblast differentiation; regulation of skeletal muscle cell differentiation; spliceosomal complex; transcription coactivator activity; transcription, DNA-dependent" IPR011545; IPR014001; IPR001650; IPR027417; IPR012587; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) DDX5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40410_c1_g1_i2 Q0D8N0 RH53_ORYSJ 7.00E-06 GO:0005524; GO:0008026; GO:0003723 ATP binding; ATP-dependent helicase activity; RNA binding IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; DEAD-box ATP-dependent RNA helicase 53 (EC 3.6.4.13) Os07g0143700 LOC_Os07g05050 Oryza sativa subsp. japonica (Rice) TR40410_c1_g1_i3 A7TTT5 DBP2_VANPO 2.00E-20 GO:0005524; GO:0008026; GO:0003723; GO:0005737; GO:0000184; GO:0005634; GO:0006364 "ATP binding; ATP-dependent helicase activity; RNA binding; cytoplasm; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus; rRNA processing" IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DBP2 (EC 3.6.4.13) DBP2 Kpol_165p1 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus) TR40410_c1_g1_i5 Q61656 DDX5_MOUSE 2.00E-67 GO:0005524; GO:0008026; GO:0003723; GO:0003724; GO:0008380; GO:0050681; GO:0007623; GO:0030331; GO:0001701; GO:0072332; GO:0006397; GO:0000122; GO:0005730; GO:0043517; GO:0045944; GO:0000381; GO:0060765; GO:0045667; GO:2001014; GO:0030529; GO:0005681; GO:0003713; GO:0006351 "ATP binding; ATP-dependent helicase activity; RNA binding; RNA helicase activity; RNA splicing; androgen receptor binding; circadian rhythm; estrogen receptor binding; in utero embryonic development; intrinsic apoptotic signaling pathway by p53 class mediator; mRNA processing; negative regulation of transcription from RNA polymerase II promoter; nucleolus; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of transcription from RNA polymerase II promoter; regulation of alternative mRNA splicing, via spliceosome; regulation of androgen receptor signaling pathway; regulation of osteoblast differentiation; regulation of skeletal muscle cell differentiation; ribonucleoprotein complex; spliceosomal complex; transcription coactivator activity; transcription, DNA-dependent" IPR011545; IPR014001; IPR001650; IPR027417; IPR012587; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box RNA helicase DEAD1) (mDEAD1) (DEAD box protein 5) (RNA helicase p68) Ddx5 Tnz2 Mus musculus (Mouse) TR40410_c1_g1_i8 A7TTT5 DBP2_VANPO 2.00E-20 GO:0005524; GO:0008026; GO:0003723; GO:0005737; GO:0000184; GO:0005634; GO:0006364 "ATP binding; ATP-dependent helicase activity; RNA binding; cytoplasm; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus; rRNA processing" IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DBP2 (EC 3.6.4.13) DBP2 Kpol_165p1 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus) TR40410_c1_g3_i1 P17844 DDX5_HUMAN 3.00E-161 GO:0005524; GO:0004004; GO:0003724; GO:0050681; GO:0071013; GO:0016049; GO:0007623; GO:0030331; GO:0001701; GO:0072332; GO:0000398; GO:0000122; GO:0005730; GO:0043517; GO:0033148; GO:0045944; GO:0036002; GO:0000381; GO:0060765; GO:0045667; GO:2001014; GO:0045069; GO:0003713; GO:0006351 Q12873; P45481; Q09472; P03372; P22087; Q13547; O95983; P10085; O94916; P24928; Q08775-3; P04637; P04637-1; P04637-7 "ATP binding; ATP-dependent RNA helicase activity; RNA helicase activity; androgen receptor binding; catalytic step 2 spliceosome; cell growth; circadian rhythm; estrogen receptor binding; in utero embryonic development; intrinsic apoptotic signaling pathway by p53 class mediator; mRNA splicing, via spliceosome; negative regulation of transcription from RNA polymerase II promoter; nucleolus; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; pre-mRNA binding; regulation of alternative mRNA splicing, via spliceosome; regulation of androgen receptor signaling pathway; regulation of osteoblast differentiation; regulation of skeletal muscle cell differentiation; regulation of viral genome replication; transcription coactivator activity; transcription, DNA-dependent" IPR011545; IPR014001; IPR001650; IPR027417; IPR012587; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) DDX5 G17P1 HELR HLR1 Homo sapiens (Human) TR40412_c0_g1_i1 Q920A5 RISC_MOUSE 7.00E-123 GO:0005829; GO:0005576; GO:0006508; GO:0042573; GO:0004185 cytosol; extracellular region; proteolysis; retinoic acid metabolic process; serine-type carboxypeptidase activity IPR001563; IPR018202; Retinoid-inducible serine carboxypeptidase (EC 3.4.16.-) (Serine carboxypeptidase 1) Scpep1 Risc Mus musculus (Mouse) TR40413_c0_g2_i2 O43175 SERA_HUMAN 9.00E-153 GO:0006564; GO:0051287; GO:0007420; GO:0022402; GO:0034641; GO:0005829; GO:0009055; GO:0009448; GO:0021782; GO:0006541; GO:0006544; GO:0021915; GO:0031175; GO:0004617; GO:0010468; GO:0021510; GO:0019530; GO:0006566 L-serine biosynthetic process; NAD binding; brain development; cell cycle process; cellular nitrogen compound metabolic process; cytosol; electron carrier activity; gamma-aminobutyric acid metabolic process; glial cell development; glutamine metabolic process; glycine metabolic process; neural tube development; neuron projection development; phosphoglycerate dehydrogenase activity; regulation of gene expression; spinal cord development; taurine metabolic process; threonine metabolic process IPR006236; IPR006139; IPR006140; IPR016040; Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3. D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) PHGDH PGDH3 Homo sapiens (Human) TR40414_c0_g2_i1 P49415 SDC_DROME 7.00E-19 GO:0050908; GO:0097009; GO:0007427; GO:0005925; GO:0016021; GO:0008045; GO:0007517; GO:0031594; GO:2000637; GO:0045887; GO:0044246 "detection of light stimulus involved in visual perception; energy homeostasis; epithelial cell migration, open tracheal system; focal adhesion; integral to membrane; motor neuron axon guidance; muscle organ development; neuromuscular junction; positive regulation of gene silencing by miRNA; positive regulation of synaptic growth at neuromuscular junction; regulation of multicellular organismal metabolic process" IPR003585; IPR001050; IPR027789; Syndecan Sdc Syd CG10497 Drosophila melanogaster (Fruit fly) TR40415_c3_g2_i1 P48493 TPIS_LACSA 2.00E-39 GO:0005737; GO:0006094; GO:0006096; GO:0006098; GO:0004807 cytoplasm; gluconeogenesis; glycolysis; pentose-phosphate shunt; triose-phosphate isomerase activity IPR013785; IPR000652; IPR020861; Carbohydrate biosynthesis; gluconeogenesis. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. "Triosephosphate isomerase, cytosolic (TIM) (Triose-phosphate isomerase) (EC 5.3.1.1) (Fragment)" Lactuca sativa (Garden lettuce) TR40415_c3_g2_i2 P48501 TPIS_SCHMA 2.00E-74 GO:0005737; GO:0006094; GO:0006096; GO:0006098; GO:0004807 cytoplasm; gluconeogenesis; glycolysis; pentose-phosphate shunt; triose-phosphate isomerase activity IPR013785; IPR022896; IPR000652; IPR020861; Carbohydrate biosynthesis; gluconeogenesis. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Triose-phosphate isomerase) TPI Schistosoma mansoni (Blood fluke) TR40415_c3_g4_i2 Q90XG0 TPISB_DANRE 3.00E-25 GO:0006094; GO:0006096; GO:0006098; GO:0004807 gluconeogenesis; glycolysis; pentose-phosphate shunt; triose-phosphate isomerase activity IPR013785; IPR022896; IPR000652; IPR020861; Carbohydrate biosynthesis; gluconeogenesis. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. Triosephosphate isomerase B (TIM-B) (EC 5.3.1.1) (Triose-phosphate isomerase B) tpi1b Danio rerio (Zebrafish) (Brachydanio rerio) TR40415_c3_g4_i3 B0BM40 TPIS_XENTR 5.00E-28 GO:0006094; GO:0006096; GO:0006098; GO:0004807 gluconeogenesis; glycolysis; pentose-phosphate shunt; triose-phosphate isomerase activity IPR013785; IPR022896; IPR000652; IPR020861; Carbohydrate biosynthesis; gluconeogenesis. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Triose-phosphate isomerase) tpi1 tpi Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40416_c0_g1_i2 Q6J3Q7 COX17_CANFA 7.00E-16 GO:0016531; GO:0006825; GO:0005758 copper chaperone activity; copper ion transport; mitochondrial intermembrane space IPR009069; IPR007745; Cytochrome c oxidase copper chaperone COX17 Canis familiaris (Dog) (Canis lupus familiaris) TR40417_c4_g2_i1 A0M595 RL2_GRAFK 1.00E-13 GO:0015934; GO:0019843; GO:0003735; GO:0016740; GO:0006412 large ribosomal subunit; rRNA binding; structural constituent of ribosome; transferase activity; translation IPR012340; IPR022666; IPR014722; IPR002171; IPR005880; IPR022669; IPR014726; IPR008991; 50S ribosomal protein L2 rplB GFO_2836 Gramella forsetii (strain KT0803) TR40417_c4_g2_i2 Q6PBF0 RL8_XENTR 2.00E-142 GO:0015934; GO:0019843; GO:0003735; GO:0006412 large ribosomal subunit; rRNA binding; structural constituent of ribosome; translation IPR012340; IPR022666; IPR014722; IPR002171; IPR023672; IPR022669; IPR022671; IPR014726; IPR008991; 60S ribosomal protein L8 rpl8 TTpA008p15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40417_c5_g1_i1 P97784 CRY1_MOUSE 0 GO:0003913; GO:0006281; GO:0007623; GO:0005829; GO:0003690; GO:0005739; GO:0000122; GO:0005654; GO:0000166; GO:0009881; GO:0000988; GO:0018298; GO:0042752; GO:0006351 Q9WTL8; O08785; Q8BFZ4; Q8C4V4; O54943 "DNA photolyase activity; DNA repair; circadian rhythm; cytosol; double-stranded DNA binding; mitochondrion; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleotide binding; photoreceptor activity; protein binding transcription factor activity; protein-chromophore linkage; regulation of circadian rhythm; transcription, DNA-dependent" IPR006050; IPR005101; IPR014729; Cryptochrome-1 Cry1 Mus musculus (Mouse) TR40419_c7_g1_i1 Q7ZVK3 SIR2_DANRE 4.00E-125 GO:0070403; GO:0005737; GO:0016811; GO:0006476; GO:0008270 "NAD+ binding; cytoplasm; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; protein deacetylation; zinc ion binding" IPR017328; IPR003000; IPR026591; IPR026590; NAD-dependent protein deacetylase sirtuin-2 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) sirt2 zgc:77003 Danio rerio (Zebrafish) (Brachydanio rerio) TR40419_c7_g1_i3 Q7ZVK3 SIR2_DANRE 3.00E-125 GO:0070403; GO:0005737; GO:0016811; GO:0006476; GO:0008270 "NAD+ binding; cytoplasm; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; protein deacetylation; zinc ion binding" IPR017328; IPR003000; IPR026591; IPR026590; NAD-dependent protein deacetylase sirtuin-2 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) sirt2 zgc:77003 Danio rerio (Zebrafish) (Brachydanio rerio) TR40420_c4_g1_i1 Q8W485 Y5010_ARATH 5.00E-21 GO:0005739 mitochondrion IPR007263; "Uncharacterized protein At5g50100, mitochondrial" At5g50100 MPF21.11 Arabidopsis thaliana (Mouse-ear cress) TR40420_c5_g4_i1 Q5R8I8 PISD_PONAB 2.00E-114 GO:0005739; GO:0006646; GO:0004609 mitochondrion; phosphatidylethanolamine biosynthetic process; phosphatidylserine decarboxylase activity IPR003817; IPR005221; Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. Phosphatidylserine decarboxylase proenzyme (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain] PISD Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40420_c5_g4_i5 P27465 PISD_CRIGR 1.00E-94 GO:0005739; GO:0006646; GO:0004609 mitochondrion; phosphatidylethanolamine biosynthetic process; phosphatidylserine decarboxylase activity IPR003817; IPR005221; Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. Phosphatidylserine decarboxylase proenzyme (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain] PISD PSSC Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR40423_c1_g2_i2 Q9H2S9 IKZF4_HUMAN 5.00E-12 GO:0003677; GO:0046872; GO:0045892; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; negative regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein Eos (Ikaros family zinc finger protein 4) IKZF4 KIAA1782 ZNFN1A4 Homo sapiens (Human) TR40425_c0_g1_i1 Q5RB36 CUL5_PONAB 3.00E-23 GO:0031461; GO:0016567; GO:0006511 cullin-RING ubiquitin ligase complex; protein ubiquitination; ubiquitin-dependent protein catabolic process IPR016157; IPR016158; IPR001373; IPR019559; IPR016159; IPR011991; Protein modification; protein ubiquitination. Cullin-5 (CUL-5) CUL5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40425_c0_g1_i8 Q5RB36 CUL5_PONAB 7.00E-24 GO:0031461; GO:0016567; GO:0006511 cullin-RING ubiquitin ligase complex; protein ubiquitination; ubiquitin-dependent protein catabolic process IPR016157; IPR016158; IPR001373; IPR019559; IPR016159; IPR011991; Protein modification; protein ubiquitination. Cullin-5 (CUL-5) CUL5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40425_c0_g2_i1 Q93034 CUL5_HUMAN 0 GO:0031466; GO:0000082; GO:0005262; GO:0007050; GO:0008283; GO:0005829; GO:0051480; GO:0097193; GO:0019048; GO:0008285; GO:0005634; GO:0005886; GO:0016567; GO:0004872; GO:0006970; GO:0031625; GO:0006511; GO:0016032 Q96Q27; O41974; P62877; P12504 Cul5-RING ubiquitin ligase complex; G1/S transition of mitotic cell cycle; calcium channel activity; cell cycle arrest; cell proliferation; cytosol; cytosolic calcium ion homeostasis; intrinsic apoptotic signaling pathway; modulation by virus of host morphology or physiology; negative regulation of cell proliferation; nucleus; plasma membrane; protein ubiquitination; receptor activity; response to osmotic stress; ubiquitin protein ligase binding; ubiquitin-dependent protein catabolic process; viral process IPR016157; IPR016158; IPR001373; IPR019559; IPR016159; IPR011991; Protein modification; protein ubiquitination. Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1) CUL5 VACM1 Homo sapiens (Human) TR40426_c0_g1_i1 Q12769 NU160_HUMAN 0 GO:0005975; GO:0019221; GO:0005829; GO:0015758; GO:0006406; GO:0007077; GO:0031080; GO:0005487; GO:0015031; GO:0010827; GO:0044281; GO:0055085; GO:0016032 carbohydrate metabolic process; cytokine-mediated signaling pathway; cytosol; glucose transport; mRNA export from nucleus; mitotic nuclear envelope disassembly; nuclear pore outer ring; nucleocytoplasmic transporter activity; protein transport; regulation of glucose transport; small molecule metabolic process; transmembrane transport; viral process IPR021717; Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Nucleoporin Nup160) NUP160 KIAA0197 NUP120 Homo sapiens (Human) TR40427_c3_g3_i1 P49024 PAXI_CHICK 2.00E-31 GO:0007160; GO:0005737; GO:0005856; GO:0005925; GO:0008270 P03126; P06931; Q9Y2X7; Q00944; P12003; P12003-1; P12003-2; Q64727 cell-matrix adhesion; cytoplasm; cytoskeleton; focal adhesion; zinc ion binding IPR001904; IPR001781; Paxillin PXN Gallus gallus (Chicken) TR40427_c3_g3_i10 Q62219 TGFI1_MOUSE 3.00E-31 GO:0016055; GO:0045165; GO:0005737; GO:0005856; GO:0030855; GO:0031012; GO:0005925; GO:0016331; GO:0045599; GO:0030512; GO:0016363; GO:0010718; GO:0045893; GO:0030511; GO:0009408; GO:0003713; GO:0030579; GO:0008270 Q8C115; Q05397 "Wnt receptor signaling pathway; cell fate commitment; cytoplasm; cytoskeleton; epithelial cell differentiation; extracellular matrix; focal adhesion; morphogenesis of embryonic epithelium; negative regulation of fat cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; nuclear matrix; positive regulation of epithelial to mesenchymal transition; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; response to heat; transcription coactivator activity; ubiquitin-dependent SMAD protein catabolic process; zinc ion binding" IPR017305; IPR001781; Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) (TGF beta-stimulated clone 5) (TSC-5) Tgfb1i1 Ara55 Mus musculus (Mouse) TR40427_c3_g3_i11 Q71FD7 FBLI1_MOUSE 2.00E-12 GO:0005938; GO:0016337; GO:0031005; GO:0005925; GO:0008360; GO:0033623; GO:0001725; GO:0008270 cell cortex; cell-cell adhesion; filamin binding; focal adhesion; regulation of cell shape; regulation of integrin activation; stress fiber; zinc ion binding IPR001781; Filamin-binding LIM protein 1 (FBLP-1) (CSX-associated LIM) Fblim1 Cal Mus musculus (Mouse) TR40427_c3_g3_i12 Q19157 PIN2_CAEEL 4.00E-65 GO:0005737; GO:0005634; GO:0043196; GO:0008270 cytoplasm; nucleus; varicosity; zinc ion binding IPR017351; IPR001781; LIM domain-containing protein pin-2 pin-2 F07C6.1 Caenorhabditis elegans TR40427_c3_g3_i14 Q7Z4I7 LIMS2_HUMAN 3.00E-160 GO:0034329; GO:0016337; GO:0045216; GO:0005829; GO:0005925; GO:0005634; GO:0005886; GO:2001046; GO:0008270 cell junction assembly; cell-cell adhesion; cell-cell junction organization; cytosol; focal adhesion; nucleus; plasma membrane; positive regulation of integrin-mediated signaling pathway; zinc ion binding IPR017351; IPR001781; LIM and senescent cell antigen-like-containing domain protein 2 (LIM-like protein 2) (Particularly interesting new Cys-His protein 2) (PINCH-2) LIMS2 PINCH2 Homo sapiens (Human) TR40427_c3_g3_i15 P49024 PAXI_CHICK 3.00E-31 GO:0007160; GO:0005737; GO:0005856; GO:0005925; GO:0008270 P03126; P06931; Q9Y2X7; Q00944; P12003; P12003-1; P12003-2; Q64727 cell-matrix adhesion; cytoplasm; cytoskeleton; focal adhesion; zinc ion binding IPR001904; IPR001781; Paxillin PXN Gallus gallus (Chicken) TR40427_c3_g3_i16 Q679P3 PDLI7_CHICK 8.00E-24 GO:0030018; GO:0030154; GO:0005856; GO:0007275; GO:0001503; GO:0008270 O93288; Q9PWE8 Z disc; cell differentiation; cytoskeleton; multicellular organismal development; ossification; zinc ion binding IPR001478; IPR001781; PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) PDLIM7 LMP RCJMB04_14g20 Gallus gallus (Chicken) TR40427_c3_g3_i17 P50464 UNC97_CAEEL 1.00E-160 GO:0031430; GO:0005912; GO:0045216; GO:0007517; GO:0005634; GO:0050954; GO:0055120; GO:0008270 Q09497 M band; adherens junction; cell-cell junction organization; muscle organ development; nucleus; sensory perception of mechanical stimulus; striated muscle dense body; zinc ion binding IPR017351; IPR001781; LIM domain-containing protein unc-97 (PINCH homolog) (Uncoordinated protein 97) unc-97 F14D12.2 Caenorhabditis elegans TR40427_c3_g3_i18 Q62219 TGFI1_MOUSE 2.00E-31 GO:0016055; GO:0045165; GO:0005737; GO:0005856; GO:0030855; GO:0031012; GO:0005925; GO:0016331; GO:0045599; GO:0030512; GO:0016363; GO:0010718; GO:0045893; GO:0030511; GO:0009408; GO:0003713; GO:0030579; GO:0008270 Q8C115; Q05397 "Wnt receptor signaling pathway; cell fate commitment; cytoplasm; cytoskeleton; epithelial cell differentiation; extracellular matrix; focal adhesion; morphogenesis of embryonic epithelium; negative regulation of fat cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; nuclear matrix; positive regulation of epithelial to mesenchymal transition; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; response to heat; transcription coactivator activity; ubiquitin-dependent SMAD protein catabolic process; zinc ion binding" IPR017305; IPR001781; Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) (TGF beta-stimulated clone 5) (TSC-5) Tgfb1i1 Ara55 Mus musculus (Mouse) TR40427_c3_g3_i2 P50464 UNC97_CAEEL 8.00E-161 GO:0031430; GO:0005912; GO:0045216; GO:0007517; GO:0005634; GO:0050954; GO:0055120; GO:0008270 Q09497 M band; adherens junction; cell-cell junction organization; muscle organ development; nucleus; sensory perception of mechanical stimulus; striated muscle dense body; zinc ion binding IPR017351; IPR001781; LIM domain-containing protein unc-97 (PINCH homolog) (Uncoordinated protein 97) unc-97 F14D12.2 Caenorhabditis elegans TR40427_c3_g3_i20 Q7Z4I7 LIMS2_HUMAN 1.00E-160 GO:0034329; GO:0016337; GO:0045216; GO:0005829; GO:0005925; GO:0005634; GO:0005886; GO:2001046; GO:0008270 cell junction assembly; cell-cell adhesion; cell-cell junction organization; cytosol; focal adhesion; nucleus; plasma membrane; positive regulation of integrin-mediated signaling pathway; zinc ion binding IPR017351; IPR001781; LIM and senescent cell antigen-like-containing domain protein 2 (LIM-like protein 2) (Particularly interesting new Cys-His protein 2) (PINCH-2) LIMS2 PINCH2 Homo sapiens (Human) TR40427_c3_g3_i3 Q7Z4I7 LIMS2_HUMAN 6.00E-160 GO:0034329; GO:0016337; GO:0045216; GO:0005829; GO:0005925; GO:0005634; GO:0005886; GO:2001046; GO:0008270 cell junction assembly; cell-cell adhesion; cell-cell junction organization; cytosol; focal adhesion; nucleus; plasma membrane; positive regulation of integrin-mediated signaling pathway; zinc ion binding IPR017351; IPR001781; LIM and senescent cell antigen-like-containing domain protein 2 (LIM-like protein 2) (Particularly interesting new Cys-His protein 2) (PINCH-2) LIMS2 PINCH2 Homo sapiens (Human) TR40427_c3_g3_i4 Q19157 PIN2_CAEEL 4.00E-65 GO:0005737; GO:0005634; GO:0043196; GO:0008270 cytoplasm; nucleus; varicosity; zinc ion binding IPR017351; IPR001781; LIM domain-containing protein pin-2 pin-2 F07C6.1 Caenorhabditis elegans TR40427_c3_g3_i5 P49024 PAXI_CHICK 4.00E-31 GO:0007160; GO:0005737; GO:0005856; GO:0005925; GO:0008270 P03126; P06931; Q9Y2X7; Q00944; P12003; P12003-1; P12003-2; Q64727 cell-matrix adhesion; cytoplasm; cytoskeleton; focal adhesion; zinc ion binding IPR001904; IPR001781; Paxillin PXN Gallus gallus (Chicken) TR40427_c3_g3_i6 Q2YDK0 FHL5_BOVIN 6.00E-16 GO:0005634; GO:0045944; GO:0003713; GO:0008270 nucleus; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; zinc ion binding IPR001781; Four and a half LIM domains protein 5 (FHL-5) FHL5 Bos taurus (Bovine) TR40427_c3_g3_i7 Q71FD7 FBLI1_MOUSE 2.00E-12 GO:0005938; GO:0016337; GO:0031005; GO:0005925; GO:0008360; GO:0033623; GO:0001725; GO:0008270 cell cortex; cell-cell adhesion; filamin binding; focal adhesion; regulation of cell shape; regulation of integrin activation; stress fiber; zinc ion binding IPR001781; Filamin-binding LIM protein 1 (FBLP-1) (CSX-associated LIM) Fblim1 Cal Mus musculus (Mouse) TR40427_c3_g3_i8 Q7Z4I7 LIMS2_HUMAN 3.00E-160 GO:0034329; GO:0016337; GO:0045216; GO:0005829; GO:0005925; GO:0005634; GO:0005886; GO:2001046; GO:0008270 cell junction assembly; cell-cell adhesion; cell-cell junction organization; cytosol; focal adhesion; nucleus; plasma membrane; positive regulation of integrin-mediated signaling pathway; zinc ion binding IPR017351; IPR001781; LIM and senescent cell antigen-like-containing domain protein 2 (LIM-like protein 2) (Particularly interesting new Cys-His protein 2) (PINCH-2) LIMS2 PINCH2 Homo sapiens (Human) TR40427_c3_g3_i9 O94929 ABLM3_HUMAN 1.00E-19 GO:0007411; GO:0005737; GO:0007010; GO:0045944; GO:0008270 axon guidance; cytoplasm; cytoskeleton organization; positive regulation of transcription from RNA polymerase II promoter; zinc ion binding IPR003128; IPR001781; Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3) ABLIM3 KIAA0843 HMFN1661 Homo sapiens (Human) TR40428_c0_g1_i1 Q00808 HETE1_PODAS 3.00E-39 GO:0005525 GTP binding IPR020472; IPR010730; IPR007111; IPR027417; IPR015943; IPR001680; IPR019775; IPR017986; Vegetative incompatibility protein HET-E-1 HET-E1 Podospora anserina (Pleurage anserina) TR40428_c0_g1_i2 P63245 GBLP_RAT 0 GO:0042169; GO:0007049; GO:0008656; GO:0005856; GO:0030425; GO:0007369; GO:0008200; GO:0030496; GO:0030178; GO:0030308; GO:0050765; GO:0051898; GO:0017148; GO:0043025; GO:0005634; GO:0043204; GO:0048471; GO:0001891; GO:0043547; GO:0043065; GO:0030335; GO:2000543; GO:2001244; GO:0032436; GO:0032464; GO:0001934; GO:0005080; GO:0007205; GO:0030292; GO:0030971; GO:0051726; GO:0051302; GO:2000114; GO:0090003; GO:0048511; GO:0015935 SH2 domain binding; cell cycle; cysteine-type endopeptidase activator activity involved in apoptotic process; cytoskeleton; dendrite; gastrulation; ion channel inhibitor activity; midbody; negative regulation of Wnt receptor signaling pathway; negative regulation of cell growth; negative regulation of phagocytosis; negative regulation of protein kinase B signaling cascade; negative regulation of translation; neuronal cell body; nucleus; perikaryon; perinuclear region of cytoplasm; phagocytic cup; positive regulation of GTPase activity; positive regulation of apoptotic process; positive regulation of cell migration; positive regulation of gastrulation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein homooligomerization; positive regulation of protein phosphorylation; protein kinase C binding; protein kinase C-activating G-protein coupled receptor signaling pathway; protein tyrosine kinase inhibitor activity; receptor tyrosine kinase binding; regulation of cell cycle; regulation of cell division; regulation of establishment of cell polarity; regulation of establishment of protein localization to plasma membrane; rhythmic process; small ribosomal subunit IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; "Guanine nucleotide-binding protein subunit beta-2-like 1 (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) (RACK1) [Cleaved into: Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed]" Gnb2l1 Rattus norvegicus (Rat) TR40429_c0_g1_i4 Q9H0R1 AP5M1_HUMAN 3.00E-68 GO:0030119; GO:0030131; GO:0005829; GO:0016197; GO:0006886; GO:0005770; GO:0031902; GO:0005765; GO:0005764; GO:0016192 AP-type membrane coat adaptor complex; clathrin adaptor complex; cytosol; endosomal transport; intracellular protein transport; late endosome; late endosome membrane; lysosomal membrane; lysosome; vesicle-mediated transport IPR008968; AP-5 complex subunit mu-1 (Adapter-related protein complex 5 subunit mu-1) (Mu5) (Mu-2-related death-inducing protein) (MuD) (Putative HIV-1 infection-related protein) AP5M1 C14orf108 MUDENG Homo sapiens (Human) TR40429_c0_g5_i2 Q499N2 AP5M1_RAT 1.00E-69 GO:0030119; GO:0030131; GO:0005829; GO:0016197; GO:0006886; GO:0005770; GO:0031902; GO:0005765; GO:0005764; GO:0016192 AP-type membrane coat adaptor complex; clathrin adaptor complex; cytosol; endosomal transport; intracellular protein transport; late endosome; late endosome membrane; lysosomal membrane; lysosome; vesicle-mediated transport IPR008968; AP-5 complex subunit mu-1 (Adapter-related protein complex 5 subunit mu-1) (Mu5) (Mu-2-related death-inducing protein) (MuD) Ap5m1 Mudeng Rattus norvegicus (Rat) TR40429_c0_g5_i3 Q9H0R1 AP5M1_HUMAN 1.00E-78 GO:0030119; GO:0030131; GO:0005829; GO:0016197; GO:0006886; GO:0005770; GO:0031902; GO:0005765; GO:0005764; GO:0016192 AP-type membrane coat adaptor complex; clathrin adaptor complex; cytosol; endosomal transport; intracellular protein transport; late endosome; late endosome membrane; lysosomal membrane; lysosome; vesicle-mediated transport IPR008968; AP-5 complex subunit mu-1 (Adapter-related protein complex 5 subunit mu-1) (Mu5) (Mu-2-related death-inducing protein) (MuD) (Putative HIV-1 infection-related protein) AP5M1 C14orf108 MUDENG Homo sapiens (Human) TR40433_c0_g1_i1 Q921R4 DJC14_MOUSE 4.00E-44 GO:0005789; GO:0016021; GO:0015031 endoplasmic reticulum membrane; integral to membrane; protein transport IPR001623; DnaJ homolog subfamily C member 14 Dnajc14 Mus musculus (Mouse) TR40433_c0_g1_i3 P19711 POLG_BVDVN 7.00E-19 GO:0005524; GO:0008026; GO:0003723; GO:0003968; GO:0075512; GO:0004197; GO:0039654; GO:0033644; GO:0044228; GO:0039520; GO:0016021; GO:0006811; GO:0006508; GO:0033897; GO:0004252; GO:0070008; GO:0039548; GO:0039501; GO:0006351; GO:0019062; GO:0019079; GO:0019082 "ATP binding; ATP-dependent helicase activity; RNA binding; RNA-directed RNA polymerase activity; clathrin-mediated endocytosis of virus by host cell; cysteine-type endopeptidase activity; fusion of virus membrane with host endosome membrane; host cell membrane; host cell surface; induction by virus of host autophagy; integral to membrane; ion transport; proteolysis; ribonuclease T2 activity; serine-type endopeptidase activity; serine-type exopeptidase activity; suppression by virus of host IRF3 activity; suppression by virus of host type I interferon production; transcription, DNA-dependent; viral attachment to host cell; viral genome replication; viral protein processing" IPR021824; IPR011492; IPR014001; IPR001650; IPR027417; IPR022120; IPR008751; IPR000280; IPR007094; IPR002166; IPR001568; IPR018188; Genome polyprotein [Cleaved into: N-terminal protease (N-pro) (EC 3.4.22.-) (Autoprotease p20); Capsid protein C; E(rns) glycoprotein (gp44/48); Envelope glycoprotein E1 (gp33); Envelope glycoprotein E2 (gp55); p7; Non-structural protein 2-3; Cysteine protease NS2 (EC 3.4.22.-) (Non-structural protein 2); Serine protease NS3 (EC 3.4.21.113) (EC 3.6.1.15) (EC 3.6.4.13) (Non-structural protein 3); Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); Non-structural protein 5A (NS5A); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B)] Bovine viral diarrhea virus (isolate NADL) (BVDV) (Mucosal disease virus) TR40433_c0_g1_i5 Q921R4 DJC14_MOUSE 2.00E-44 GO:0005789; GO:0016021; GO:0015031 endoplasmic reticulum membrane; integral to membrane; protein transport IPR001623; DnaJ homolog subfamily C member 14 Dnajc14 Mus musculus (Mouse) TR40433_c0_g1_i6 Q921R4 DJC14_MOUSE 4.00E-44 GO:0005789; GO:0016021; GO:0015031 endoplasmic reticulum membrane; integral to membrane; protein transport IPR001623; DnaJ homolog subfamily C member 14 Dnajc14 Mus musculus (Mouse) TR40433_c0_g1_i7 Q5XIX0 DJC14_RAT 1.00E-43 GO:0050780; GO:0005789; GO:0016021; GO:0015031 dopamine receptor binding; endoplasmic reticulum membrane; integral to membrane; protein transport IPR001623; DnaJ homolog subfamily C member 14 (Dopamine receptor-interacting protein of 78 kDa) (DRiP78) Dnajc14 Drip78 Rattus norvegicus (Rat) TR40433_c0_g1_i9 Q921R4 DJC14_MOUSE 2.00E-44 GO:0005789; GO:0016021; GO:0015031 endoplasmic reticulum membrane; integral to membrane; protein transport IPR001623; DnaJ homolog subfamily C member 14 Dnajc14 Mus musculus (Mouse) TR40434_c1_g1_i2 Q8BTS4 NUP54_MOUSE 1.00E-134 GO:0051028; GO:0031965; GO:0005643; GO:0005487; GO:0006605 mRNA transport; nuclear membrane; nuclear pore; nucleocytoplasmic transporter activity; protein targeting IPR024864; IPR025712; Nuclear pore complex protein Nup54 (54 kDa nucleoporin) (Nucleoporin Nup54) Nup54 Mus musculus (Mouse) TR40434_c1_g1_i4 O42963 NUP44_SCHPO 4.00E-16 GO:0005829; GO:0031965; GO:0005643; GO:0006407; GO:0007346 cytosol; nuclear membrane; nuclear pore; rRNA export from nucleus; regulation of mitotic cell cycle IPR024864; IPR025712; Nucleoporin nup44 (Nuclear pore protein nup44) nup44 SPBC19G7.15 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40435_c2_g2_i1 Q9PSX7 RHOC_CHICK 5.00E-18 GO:0005525; GO:0043297; GO:0032154; GO:0000910; GO:0005634; GO:0005886; GO:0043123; GO:0004871; GO:0007264 GTP binding; apical junction assembly; cleavage furrow; cytokinesis; nucleus; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Rho-related GTP-binding protein RhoC RHOC ARHC Gallus gallus (Chicken) TR40435_c2_g2_i2 Q9UL25 RAB21_HUMAN 3.00E-99 GO:0019003; GO:0005525; GO:0003924; GO:0000139; GO:0032154; GO:0030659; GO:0031901; GO:0005789; GO:0005768; GO:0015031; GO:0007264 Q9UKG1 GDP binding; GTP binding; GTPase activity; Golgi membrane; cleavage furrow; cytoplasmic vesicle membrane; early endosome membrane; endoplasmic reticulum membrane; endosome; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-21 RAB21 KIAA0118 Homo sapiens (Human) TR40436_c2_g1_i1 P11833 TBB_PARLI 0 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR013838; IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta chain (Beta-tubulin) Paracentrotus lividus (Common sea urchin) TR40436_c2_g1_i11 P11833 TBB_PARLI 0 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR013838; IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta chain (Beta-tubulin) Paracentrotus lividus (Common sea urchin) TR40436_c2_g1_i12 P18700 TBB_STRPU 0 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR003008; Tubulin beta chain (Beta-tubulin) (Fragment) Strongylocentrotus purpuratus (Purple sea urchin) TR40436_c2_g1_i4 P86221 TBB4B_MESAU 5.00E-102 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR013838; IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta-4B chain (Tubulin beta-2C chain) (Fragments) TUBB4B TUBB2C Mesocricetus auratus (Golden hamster) TR40436_c2_g1_i6 P86234 TBA3_MESAU 6.00E-16 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization IPR008280; IPR000217; IPR018316; IPR003008; Tubulin alpha-3 chain (Fragments) Mesocricetus auratus (Golden hamster) TR40436_c2_g1_i7 Q6VAF8 TBB3_GOSHI 0 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR013838; IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta-3 chain (Beta-3-tubulin) Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) TR40436_c2_g1_i8 P05219 TBB_SCHPO 0 GO:0005525; GO:0003924; GO:0000235; GO:0005829; GO:0071963; GO:0048312; GO:0051258; GO:0046677; GO:0007103; GO:0005200 GTP binding; GTPase activity; astral microtubule; cytosol; establishment or maintenance of cell polarity regulating cell shape; intracellular distribution of mitochondria; protein polymerization; response to antibiotic; spindle pole body duplication associated with nuclear envelope; structural constituent of cytoskeleton IPR013838; IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta chain (Beta-tubulin) nda3 alp12 SPBC26H8.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40436_c2_g1_i9 P86234 TBA3_MESAU 4.00E-17 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization IPR008280; IPR000217; IPR018316; IPR003008; Tubulin alpha-3 chain (Fragments) Mesocricetus auratus (Golden hamster) TR40438_c0_g1_i2 Q5XGY1 TSR1_XENLA 0 GO:0005730; GO:0042255 nucleolus; ribosome assembly IPR012948; IPR007034; Pre-rRNA-processing protein TSR1 homolog tsr1 Xenopus laevis (African clawed frog) TR40441_c0_g1_i3 Q8JZV4 RBM41_MOUSE 3.00E-21 GO:0003723; GO:0000166 RNA binding; nucleotide binding IPR012677; IPR000504; RNA-binding protein 41 (RNA-binding motif protein 41) Rbm41 Mus musculus (Mouse) TR40441_c0_g2_i5 Q3UZ01 RBM40_MOUSE 1.00E-50 GO:0003723; GO:0005689; GO:0000166 RNA binding; U12-type spliceosomal complex; nucleotide binding IPR012677; IPR000504; RNA-binding protein 40 (RNA-binding motif protein 40) (RNA-binding region-containing protein 3) Rnpc3 Kiaa1839 Rbm40 Mus musculus (Mouse) TR40443_c1_g1_i1 Q9EP86 NPFF1_RAT 2.00E-20 GO:0016021; GO:0008188; GO:0007218; GO:0005886 integral to membrane; neuropeptide receptor activity; neuropeptide signaling pathway; plasma membrane IPR000276; IPR017452; IPR005395; IPR005396; Neuropeptide FF receptor 1 (G-protein coupled receptor 147) (RFamide-related peptide receptor OT7T022) Npffr1 Gpr147 Npff1 Rattus norvegicus (Rat) TR40443_c1_g1_i2 P21452 NK2R_HUMAN 2.00E-32 GO:0007588; GO:0005887; GO:0014827; GO:0006936; GO:0033685; GO:0035106; GO:0014057; GO:0070474; GO:0043117; GO:0070459; GO:0006950; GO:0016497; GO:0004995 P20366 "excretion; integral to plasma membrane; intestine smooth muscle contraction; muscle contraction; negative regulation of luteinizing hormone secretion; operant conditioning; positive regulation of acetylcholine secretion, neurotransmission; positive regulation of uterine smooth muscle contraction; positive regulation of vascular permeability; prolactin secretion; response to stress; substance K receptor activity; tachykinin receptor activity" IPR000276; IPR017452; IPR001681; IPR000913; Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2) TACR2 NK2R NKNAR TAC2R Homo sapiens (Human) TR40443_c1_g1_i3 Q63634 NPY5R_RAT 5.00E-13 GO:0003214; GO:0005737; GO:0042755; GO:0060112; GO:0016021; GO:0043066; GO:0014050; GO:0032229; GO:0003151; GO:0001602; GO:0001601; GO:0005886; GO:0002675; GO:0048661 "cardiac left ventricle morphogenesis; cytoplasm; eating behavior; generation of ovulation cycle rhythm; integral to membrane; negative regulation of apoptotic process; negative regulation of glutamate secretion; negative regulation of synaptic transmission, GABAergic; outflow tract morphogenesis; pancreatic polypeptide receptor activity; peptide YY receptor activity; plasma membrane; positive regulation of acute inflammatory response; positive regulation of smooth muscle cell proliferation" IPR000276; IPR017452; IPR000393; IPR000611; Neuropeptide Y receptor type 5 (NPY5-R) (NPY-Y5 receptor) (NPYY5-R) (Y5 receptor) Npy5r Npyr5 Rattus norvegicus (Rat) TR40443_c1_g2_i1 O97512 NK3R_RABIT 4.00E-08 GO:0016021; GO:0005886; GO:0004995; GO:0007217 integral to membrane; plasma membrane; tachykinin receptor activity; tachykinin receptor signaling pathway IPR000276; IPR017452; IPR001681; IPR001013; Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3) TACR3 Oryctolagus cuniculus (Rabbit) TR40445_c7_g1_i1 P24821 TENA_HUMAN 1.00E-07 GO:0005604; GO:0007155; GO:0030198; GO:0005615; GO:0005614; GO:0060739; GO:0007528; GO:0014012; GO:0008284; GO:0010628; GO:0060740; GO:0009611 basement membrane; cell adhesion; extracellular matrix organization; extracellular space; interstitial matrix; mesenchymal-epithelial cell signaling involved in prostate gland development; neuromuscular junction development; peripheral nervous system axon regeneration; positive regulation of cell proliferation; positive regulation of gene expression; prostate gland epithelium morphogenesis; response to wounding IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) TNC HXB Homo sapiens (Human) TR40445_c7_g1_i3 Q55E58 PATS1_DICDI 4.00E-12 GO:0005524; GO:0005525; GO:0042641; GO:0000281; GO:0004721; GO:0006470; GO:0004674; GO:0007264 ATP binding; GTP binding; actomyosin; mitotic cytokinesis; phosphoprotein phosphatase activity; protein dephosphorylation; protein serine/threonine kinase activity; small GTPase mediated signal transduction IPR011009; IPR001611; IPR013684; IPR010569; IPR017906; IPR027417; IPR000719; IPR011047; IPR020859; IPR001245; IPR008271; IPR005225; IPR001806; IPR015943; IPR001680; IPR017986; Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) TR40446_c0_g2_i2 Q1LUC1 BZW2_DANRE 5.00E-105 GO:0030154; GO:0007399 cell differentiation; nervous system development IPR016024; IPR016021; IPR003307; Basic leucine zipper and W2 domain-containing protein 2 bzw2 si:ch211-210b19.1 zgc:55580 Danio rerio (Zebrafish) (Brachydanio rerio) TR40448_c2_g5_i1 Q91XL3 UXS1_MOUSE 6.00E-12 GO:0032580; GO:0033320; GO:0048040; GO:0050662; GO:0016021; GO:0005739 Golgi cisterna membrane; UDP-D-xylose biosynthetic process; UDP-glucuronate decarboxylase activity; coenzyme binding; integral to membrane; mitochondrion IPR001509; IPR016040; IPR021761; Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1. UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1) Uxs1 Mus musculus (Mouse) TR40448_c2_g5_i3 Q8K3X2 FCL_CRIGR 4.00E-172 GO:0042351; GO:0050577; GO:0050662; GO:0016853 'de novo' GDP-L-fucose biosynthetic process; GDP-L-fucose synthase activity; coenzyme binding; isomerase activity IPR001509; IPR016040; Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2. "GDP-L-fucose synthase (EC 1.1.1.271) (GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase) (Protein FX) (Red cell NADP(H)-binding protein)" TSTA3 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR40448_c2_g5_i4 Q67WR2 FCL1_ORYSJ 4.00E-51 GO:0042351; GO:0050577; GO:0050662; GO:0016853 'de novo' GDP-L-fucose biosynthetic process; GDP-L-fucose synthase activity; coenzyme binding; isomerase activity IPR001509; IPR016040; Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2. "Probable GDP-L-fucose synthase 1 (EC 1.1.1.271) (GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase 1)" Os06g0652400 LOC_Os06g44270 OSJNBa0085J13.7 Oryza sativa subsp. japonica (Rice) TR40448_c2_g5_i7 Q8K3X2 FCL_CRIGR 1.00E-174 GO:0042351; GO:0050577; GO:0050662; GO:0016853 'de novo' GDP-L-fucose biosynthetic process; GDP-L-fucose synthase activity; coenzyme binding; isomerase activity IPR001509; IPR016040; Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2. "GDP-L-fucose synthase (EC 1.1.1.271) (GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase) (Protein FX) (Red cell NADP(H)-binding protein)" TSTA3 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR40450_c1_g1_i1 Q32TF8 EFHC2_DANRE 0 GO:0005509 calcium ion binding IPR010554; IPR011992; IPR002048; IPR006602; EF-hand domain-containing family member C2 efhc2 zgc:152706 Danio rerio (Zebrafish) (Brachydanio rerio) TR40451_c2_g2_i1 Q63604 NTRK2_RAT 7.00E-07 GO:0005524; GO:0000139; GO:0007568; GO:0043679; GO:0048403; GO:0060175; GO:0035584; GO:0009986; GO:0021954; GO:0021987; GO:0005829; GO:0043197; GO:0010008; GO:0060076; GO:0007631; GO:0014047; GO:0030426; GO:0005887; GO:0007612; GO:0007616; GO:0060291; GO:0042490; GO:2000811; GO:0043524; GO:0007528; GO:0001764; GO:0043025; GO:0048709; GO:0048935; GO:0043410; GO:0050772; GO:0008284; GO:0010628; GO:0010976; GO:0014068; GO:0051968; GO:0014069; GO:0045211; GO:0048786; GO:0046777; GO:0042803; GO:0032314; GO:0050773; GO:0046928; GO:0051896; GO:0010996; GO:0046548; GO:0043195; GO:0001570 Q8K4V6 "ATP binding; Golgi membrane; aging; axon terminus; brain-derived neurotrophic factor binding; brain-derived neurotrophic factor-activated receptor activity; calcium-mediated signaling using intracellular calcium source; cell surface; central nervous system neuron development; cerebral cortex development; cytosol; dendritic spine; endosome membrane; excitatory synapse; feeding behavior; glutamate secretion; growth cone; integral to plasma membrane; learning; long-term memory; long-term synaptic potentiation; mechanoreceptor differentiation; negative regulation of anoikis; negative regulation of neuron apoptotic process; neuromuscular junction development; neuron migration; neuronal cell body; oligodendrocyte differentiation; peripheral nervous system neuron development; positive regulation of MAPK cascade; positive regulation of axonogenesis; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of neuron projection development; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of synaptic transmission, glutamatergic; postsynaptic density; postsynaptic membrane; presynaptic active zone; protein autophosphorylation; protein homodimerization activity; regulation of Rac GTPase activity; regulation of dendrite development; regulation of neurotransmitter secretion; regulation of protein kinase B signaling cascade; response to auditory stimulus; retinal rod cell development; terminal bouton; vasculogenesis" IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000372; IPR000719; IPR017441; IPR001245; IPR020455; IPR008266; IPR020635; IPR020777; IPR002011; BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Ntrk2 Trkb Rattus norvegicus (Rat) TR40451_c2_g3_i1 P58681 TLR7_MOUSE 7.00E-08 GO:0007252; GO:0002755; GO:0071260; GO:0051607; GO:0003725; GO:0032009; GO:0005783; GO:0005789; GO:0005768; GO:0006954; GO:0045087; GO:0016021; GO:0005764; GO:0005886; GO:0042346; GO:0032722; GO:0045356; GO:0045359; GO:0045078; GO:0032755; GO:0045416; GO:0032757; GO:0035197; GO:0003727; GO:0034154; GO:0004888 I-kappaB phosphorylation; MyD88-dependent toll-like receptor signaling pathway; cellular response to mechanical stimulus; defense response to virus; double-stranded RNA binding; early phagosome; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; inflammatory response; innate immune response; integral to membrane; lysosome; plasma membrane; positive regulation of NF-kappaB import into nucleus; positive regulation of chemokine production; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-6 production; positive regulation of interleukin-8 biosynthetic process; positive regulation of interleukin-8 production; siRNA binding; single-stranded RNA binding; toll-like receptor 7 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; IPR026880; Toll-like receptor 7 Tlr7 Mus musculus (Mouse) TR40451_c2_g4_i1 Q9QUK6 TLR4_MOUSE 2.00E-12 GO:0002322; GO:0007252; GO:0002755; GO:0000187; GO:0007250; GO:0071223; GO:0071260; GO:0050829; GO:0032497; GO:0009897; GO:0045087; GO:0005887; GO:0032609; GO:0060729; GO:0001875; GO:0046696; GO:0042116; GO:0045576; GO:0070373; GO:0032689; GO:0032700; GO:0032707; GO:0032715; GO:0032720; GO:0002537; GO:0048471; GO:0030890; GO:0070374; GO:0043123; GO:0046330; GO:0045348; GO:0042346; GO:0051092; GO:0032722; GO:0032727; GO:0045359; GO:0032728; GO:0032729; GO:0045362; GO:0032732; GO:0032733; GO:0045084; GO:0032735; GO:0045368; GO:0045410; GO:0032755; GO:0045416; GO:0032757; GO:0060907; GO:0045429; GO:0051770; GO:0070430; GO:0070434; GO:0010572; GO:0045944; GO:0042535; GO:0032760; GO:0050707; GO:0050727; GO:0034142; GO:0004888 Q9JHF9 B cell proliferation involved in immune response; I-kappaB phosphorylation; MyD88-dependent toll-like receptor signaling pathway; activation of MAPK activity; activation of NF-kappaB-inducing kinase activity; cellular response to lipoteichoic acid; cellular response to mechanical stimulus; defense response to Gram-negative bacterium; detection of lipopolysaccharide; external side of plasma membrane; innate immune response; integral to plasma membrane; interferon-gamma production; intestinal epithelial structure maintenance; lipopolysaccharide receptor activity; lipopolysaccharide receptor complex; macrophage activation; mast cell activation; negative regulation of ERK1 and ERK2 cascade; negative regulation of interferon-gamma production; negative regulation of interleukin-17 production; negative regulation of interleukin-23 production; negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production; nitric oxide production involved in inflammatory response; perinuclear region of cytoplasm; positive regulation of B cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; positive regulation of MHC class II biosynthetic process; positive regulation of NF-kappaB import into nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of chemokine production; positive regulation of interferon-alpha production; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; positive regulation of interferon-gamma production; positive regulation of interleukin-1 biosynthetic process; positive regulation of interleukin-1 production; positive regulation of interleukin-10 production; positive regulation of interleukin-12 biosynthetic process; positive regulation of interleukin-12 production; positive regulation of interleukin-13 biosynthetic process; positive regulation of interleukin-6 biosynthetic process; positive regulation of interleukin-6 production; positive regulation of interleukin-8 biosynthetic process; positive regulation of interleukin-8 production; positive regulation of macrophage cytokine production; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; positive regulation of platelet activation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of tumor necrosis factor production; regulation of cytokine secretion; regulation of inflammatory response; toll-like receptor 4 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR000157; IPR027168; IPR017241; Toll-like receptor 4 (CD antigen CD284) Tlr4 Lps Mus musculus (Mouse) TR40451_c2_g4_i2 Q45R42 LRRC4_RAT 5.00E-15 GO:0030054; GO:0016021; GO:0045211 cell junction; integral to membrane; postsynaptic membrane IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; IPR026906; IPR026882; Leucine-rich repeat-containing protein 4 (Netrin-G2 ligand) (NGL-2) Lrrc4 Rattus norvegicus (Rat) TR40451_c3_g2_i3 Q9DGB6 TLR22_CHICK 2.00E-18 GO:0002755; GO:0042494; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0034134; GO:0002224; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; detection of bacterial lipoprotein; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; toll-like receptor 2 signaling pathway; toll-like receptor signaling pathway; transmembrane signaling receptor activity IPR000483; IPR018247; IPR001611; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 type-2 TLR2-2 Gallus gallus (Chicken) TR40451_c3_g2_i4 B3Y618 TLR2_MACMU 1.00E-16 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Macaca mulatta (Rhesus macaque) TR40451_c3_g2_i5 Q689D1 TLR2_CANFA 3.00E-17 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Canis familiaris (Dog) (Canis lupus familiaris) TR40451_c3_g2_i6 Q9JLF7 TLR5_MOUSE 1.00E-07 GO:0002755; GO:0042742; GO:0006954; GO:0045087; GO:0016021; GO:0001819; GO:0050707; GO:0034146; GO:0004888 Q56086; E1WGJ5 MyD88-dependent toll-like receptor signaling pathway; defense response to bacterium; inflammatory response; innate immune response; integral to membrane; positive regulation of cytokine production; regulation of cytokine secretion; toll-like receptor 5 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027176; Toll-like receptor 5 Tlr5 Mus musculus (Mouse) TR40451_c3_g2_i7 Q689D1 TLR2_CANFA 1.00E-10 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Canis familiaris (Dog) (Canis lupus familiaris) TR40452_c2_g2_i1 P42322 CANB1_NAEGR 4.00E-22 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calcineurin subunit B (Calcineurin regulatory subunit) (Protein phosphatase 2B regulatory subunit) CNB1 Naegleria gruberi (Amoeba) TR40452_c2_g2_i2 Q16981 APLC_APLCA 5.00E-105 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Neuronal calcium sensor 1 (NCS-1) (Aplycalcin) Aplysia californica (California sea hare) TR40453_c5_g1_i1 Q9Y6R7 FCGBP_HUMAN 2.00E-08 GO:0005737; GO:0005576 cytoplasm; extracellular region IPR003645; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) TR40453_c6_g4_i10 P22105 TENX_HUMAN 3.00E-09 GO:0030036; GO:0007155; GO:0016337; GO:0007160; GO:0030199; GO:0032963; GO:0048251; GO:0043206; GO:0005615; GO:0006631; GO:0008201; GO:0005178; GO:0005622; GO:0005578; GO:0043506; GO:0006641 actin cytoskeleton organization; cell adhesion; cell-cell adhesion; cell-matrix adhesion; collagen fibril organization; collagen metabolic process; elastic fiber assembly; extracellular fibril organization; extracellular space; fatty acid metabolic process; heparin binding; integrin binding; intracellular; proteinaceous extracellular matrix; regulation of JUN kinase activity; triglyceride metabolic process IPR000742; IPR013032; IPR014716; IPR014715; IPR002181; IPR020837; IPR003961; IPR013783; Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) TR40453_c6_g4_i5 Q9W7R4 TEN3_DANRE 1.00E-07 GO:0030424; GO:0007156; GO:0016021; GO:0016020; GO:0010976; GO:0046982; GO:0042803; GO:0007165 axon; homophilic cell adhesion; integral to membrane; membrane; positive regulation of neuron projection development; protein heterodimerization activity; protein homodimerization activity; signal transduction IPR011042; IPR008969; IPR000742; IPR013032; IPR022385; IPR027689; IPR009471; IPR006530; Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) tenm3 odz3 tnm3 Danio rerio (Zebrafish) (Brachydanio rerio) TR40454_c1_g1_i1 Q9NWZ3 IRAK4_HUMAN 6.00E-70 GO:0005524; GO:0007254; GO:0002755; GO:0001816; GO:0019221; GO:0005829; GO:0010008; GO:0045087; GO:0000287; GO:0005886; GO:0048661; GO:0045944; GO:0004674; GO:0034166; GO:0034134; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124 Q9HAT8; P58753 ATP binding; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; cytokine production; cytokine-mediated signaling pathway; cytosol; endosome membrane; innate immune response; magnesium ion binding; plasma membrane; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; protein serine/threonine kinase activity; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor TLR1:TLR2 signaling pathway; toll-like receptor TLR6:TLR2 signaling pathway IPR011029; IPR017428; IPR011009; IPR000719; Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) IRAK4 Homo sapiens (Human) TR40454_c1_g1_i2 Q9LFL7 Y5140_ARATH 6.00E-13 GO:0005524; GO:0004672 ATP binding; protein kinase activity IPR011009; IPR000719; IPR001245; Putative inactive serine/threonine-protein kinase At5g11400 At5g11400 F2I11.290 Arabidopsis thaliana (Mouse-ear cress) TR40455_c4_g1_i1 Q80U16 FA65B_MOUSE 2.00E-37 IPR011989; IPR016024; IPR026136; Protein FAM65B Fam65b Kiaa0386 Mus musculus (Mouse) TR40455_c4_g1_i5 Q5F3L9 FA65B_CHICK 2.00E-56 IPR026136; Protein FAM65B (Myogenesis-related and NCAM-associated protein) (MYONAP) FAM65B MYONAP RCJMB04_13m20 Gallus gallus (Chicken) TR40455_c4_g1_i8 Q5F3L9 FA65B_CHICK 3.00E-58 IPR026136; Protein FAM65B (Myogenesis-related and NCAM-associated protein) (MYONAP) FAM65B MYONAP RCJMB04_13m20 Gallus gallus (Chicken) TR40458_c1_g2_i2 Q8BZM0 KLH12_MOUSE 4.00E-62 GO:0048208; GO:0031463; GO:0030134; GO:0016055; GO:0006513 COPII vesicle coating; Cul3-RING ubiquitin ligase complex; ER to Golgi transport vesicle; Wnt receptor signaling pathway; protein monoubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 12 (CUL3-interacting protein 1) Klhl12 C3ip1 Mus musculus (Mouse) TR40458_c1_g2_i4 Q6V595 KLHL6_MOUSE 6.00E-10 GO:0050853; GO:0002467 B cell receptor signaling pathway; germinal center formation IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 6 Klhl6 Mus musculus (Mouse) TR40458_c1_g2_i8 P57790 KEAP1_RAT 2.00E-33 GO:0031463; GO:0019694; GO:0005913; GO:0071407; GO:0005737; GO:0042994; GO:0009812; GO:0005925; GO:0006108; GO:0010629; GO:0005634; GO:0010499; GO:0051259; GO:0016567; GO:0006355; GO:0035902; GO:0010038; GO:0097066; GO:0001887; GO:0006351 "Cul3-RING ubiquitin ligase complex; alkanesulfonate metabolic process; cell-cell adherens junction; cellular response to organic cyclic compound; cytoplasm; cytoplasmic sequestering of transcription factor; flavonoid metabolic process; focal adhesion; malate metabolic process; negative regulation of gene expression; nucleus; proteasomal ubiquitin-independent protein catabolic process; protein oligomerization; protein ubiquitination; regulation of transcription, DNA-dependent; response to immobilization stress; response to metal ion; response to thyroid hormone stimulus; selenium compound metabolic process; transcription, DNA-dependent" IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) Keap1 Inrf2 Rattus norvegicus (Rat) TR40458_c1_g4_i1 Q53G59 KLH12_HUMAN 2.00E-166 GO:0048208; GO:0031463; GO:0030134; GO:0016055; GO:0006513 P54253; Q9UBV8 COPII vesicle coating; Cul3-RING ubiquitin ligase complex; ER to Golgi transport vesicle; Wnt receptor signaling pathway; protein monoubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR) KLHL12 C3IP1 Homo sapiens (Human) TR40458_c1_g4_i2 Q8N239 KLH34_HUMAN 4.00E-27 IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 34 KLHL34 Homo sapiens (Human) TR40459_c1_g1_i1 Q9XXV8 MYOK_DICDI 3.00E-35 GO:0005524; GO:0051015; GO:0033109; GO:0032009; GO:0070685; GO:0003774; GO:0016459; GO:0097203; GO:0006911; GO:2000147; GO:0050766; GO:0001726 "ATP binding; actin filament binding; cortical actin cytoskeleton stabilization; early phagosome; macropinocytic cup; motor activity; myosin complex; phagocytic cup lip; phagocytosis, engulfment; positive regulation of cell motility; positive regulation of phagocytosis; ruffle" IPR001609; IPR027417; Myosin-K heavy chain myoK myoIG DDB_G0274575 Dictyostelium discoideum (Slime mold) TR40459_c10_g1_i1 A5PF48 MYO1C_DANRE 4.00E-27 GO:0005524; GO:0005737; GO:0003774; GO:0016459; GO:0060171 ATP binding; cytoplasm; motor activity; myosin complex; stereocilium membrane IPR000048; IPR001609; IPR010926; IPR027417; Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) myo1c si:ch211-69i14.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR40459_c4_g1_i1 Q9QYF3 MYO5A_RAT 1.00E-52 GO:0005524; GO:0042642; GO:0030424; GO:0032869; GO:0032593; GO:0000146; GO:0043025; GO:0043473; GO:0046982; GO:0072659; GO:0017157; GO:0032252; GO:0008021; GO:0030050; GO:0016192 "ATP binding; actomyosin, myosin complex part; axon; cellular response to insulin stimulus; insulin-responsive compartment; microfilament motor activity; neuronal cell body; pigmentation; protein heterodimerization activity; protein localization to plasma membrane; regulation of exocytosis; secretory granule localization; synaptic vesicle; vesicle transport along actin filament; vesicle-mediated transport" IPR018444; IPR002710; IPR000048; IPR001609; IPR027417; "Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle)" Myo5a Rattus norvegicus (Rat) TR40459_c4_g2_i1 O43795 MYO1B_HUMAN 9.00E-95 GO:0005524; GO:0051017; GO:0030048; GO:0005903; GO:0005737; GO:0030175; GO:0000146; GO:0016459; GO:0005547; GO:0005546; GO:0005886 "ATP binding; actin filament bundle assembly; actin filament-based movement; brush border; cytoplasm; filopodium; microfilament motor activity; myosin complex; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; plasma membrane" IPR000048; IPR001609; IPR010926; IPR027417; Unconventional myosin-Ib (MYH-1c) (Myosin I alpha) (MMI-alpha) (MMIa) MYO1B Homo sapiens (Human) TR40459_c9_g2_i1 P46735 MYO1B_MOUSE 2.00E-92 GO:0005524; GO:0051017; GO:0030048; GO:0005903; GO:0005737; GO:0030175; GO:0000146; GO:0016459; GO:0005547; GO:0005546; GO:0005886 "ATP binding; actin filament bundle assembly; actin filament-based movement; brush border; cytoplasm; filopodium; microfilament motor activity; myosin complex; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; plasma membrane" IPR000048; IPR001609; IPR010926; IPR027417; Unconventional myosin-Ib (MIH-L) (Myosin I alpha) (MMI-alpha) (MMIa) Myo1b Mus musculus (Mouse) TR40459_c9_g2_i2 P46735 MYO1B_MOUSE 9.00E-63 GO:0005524; GO:0051017; GO:0030048; GO:0005903; GO:0005737; GO:0030175; GO:0000146; GO:0016459; GO:0005547; GO:0005546; GO:0005886 "ATP binding; actin filament bundle assembly; actin filament-based movement; brush border; cytoplasm; filopodium; microfilament motor activity; myosin complex; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; plasma membrane" IPR000048; IPR001609; IPR010926; IPR027417; Unconventional myosin-Ib (MIH-L) (Myosin I alpha) (MMI-alpha) (MMIa) Myo1b Mus musculus (Mouse) TR40461_c0_g1_i3 Q7Z4R8 CF120_HUMAN 4.00E-30 GO:0006915; GO:0005576 apoptotic process; extracellular region UPF0669 protein C6orf120 C6orf120 Homo sapiens (Human) TR40462_c0_g2_i1 Q54N00 FORH_DICDI 3.00E-09 GO:0015629; GO:0051015; GO:0045010; GO:0051638; GO:0005938; GO:0000902; GO:0031589; GO:0006928; GO:0030175; GO:0046847; GO:0031268 P34144; Q5TJ65 actin cytoskeleton; actin filament binding; actin nucleation; barbed-end actin filament uncapping; cell cortex; cell morphogenesis; cell-substrate adhesion; cellular component movement; filopodium; filopodium assembly; pseudopodium organization IPR016024; IPR015425; IPR010472; IPR010473; IPR014768; Formin-H (Diaphanous-related formin dia2) (dDia2) forH dia2 drf2 DDB_G0285589 Dictyostelium discoideum (Slime mold) TR40462_c1_g1_i1 P48608 DIA_DROME 1.00E-51 GO:0003779; GO:0007015; GO:0005912; GO:0003383; GO:0045177; GO:0005938; GO:0032154; GO:0000915; GO:0005856; GO:0032507; GO:0007110; GO:0007111; GO:0035011; GO:0045448; GO:0022008; GO:0007424; GO:0007279; GO:0043234; GO:0009306; GO:0030589; GO:0016476; GO:0051489; GO:0007605; GO:0007283; GO:0051225 "actin binding; actin filament organization; adherens junction; apical constriction; apical part of cell; cell cortex; cleavage furrow; cytokinesis, actomyosin contractile ring assembly; cytoskeleton; maintenance of protein location in cell; meiosis I cytokinesis; meiosis II cytokinesis; melanotic encapsulation of foreign target; mitotic cell cycle, embryonic; neurogenesis; open tracheal system development; pole cell formation; protein complex; protein secretion; pseudocleavage involved in syncytial blastoderm formation; regulation of embryonic cell shape; regulation of filopodium assembly; sensory perception of sound; spermatogenesis; spindle assembly" IPR016024; IPR014767; IPR010465; IPR015425; IPR010472; IPR027658; IPR010473; IPR014768; Protein diaphanous dia CG1768 Drosophila melanogaster (Fruit fly) TR40463_c1_g2_i1 Q9Y6Y8 S23IP_HUMAN 9.00E-151 GO:0012507; GO:0007030; GO:0005783; GO:0005793; GO:0006886; GO:0046872 ER to Golgi transport vesicle membrane; Golgi organization; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; intracellular protein transport; metal ion binding IPR004177; IPR001660; IPR013761; IPR021129; SEC23-interacting protein (p125) SEC23IP MSTP053 Homo sapiens (Human) TR40465_c1_g1_i1 Q14562 DHX8_HUMAN 0 GO:0005524; GO:0004004; GO:0003723; GO:0071013; GO:0000398 Itself; Q8IWX8; Q9ULR0; Q8N5F7 "ATP binding; ATP-dependent RNA helicase activity; RNA binding; catalytic step 2 spliceosome; mRNA splicing, via spliceosome" IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR012340; IPR027417; IPR003029; IPR022967; ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) DHX8 DDX8 Homo sapiens (Human) TR40466_c6_g1_i1 P08570 RLA1_DROME 6.00E-26 GO:0005840; GO:0003735; GO:0006414 ribosome; structural constituent of ribosome; translational elongation IPR001813; IPR027534; 60S acidic ribosomal protein P1 (Acidic ribosomal protein RPA2) (RP21C) RpLP1 M(2)21C rp21C RPA2 RpP2 CG4087 Drosophila melanogaster (Fruit fly) TR40466_c7_g2_i1 Q1LWC2 T106B_DANRE 3.00E-28 GO:0016021; GO:0031902; GO:0005765 integral to membrane; late endosome membrane; lysosomal membrane IPR009790; Transmembrane protein 106B tmem106b ch211-134n17.2 ch211-195l15.2 zgc:114147 Danio rerio (Zebrafish) (Brachydanio rerio) TR40467_c0_g2_i1 Q8CGZ0 CHERP_MOUSE 1.00E-21 GO:0003723; GO:0006396; GO:0005783; GO:0008285; GO:0048471; GO:0051533; GO:0051209 RNA binding; RNA processing; endoplasmic reticulum; negative regulation of cell proliferation; perinuclear region of cytoplasm; positive regulation of NFAT protein import into nucleus; release of sequestered calcium ion into cytosol IPR006569; IPR008942; IPR000467; IPR006903; IPR000061; Calcium homeostasis endoplasmic reticulum protein (SR-related CTD-associated factor 6) Cherp Scaf6 Mus musculus (Mouse) TR40467_c0_g3_i1 Q8CGZ0 CHERP_MOUSE 2.00E-45 GO:0003723; GO:0006396; GO:0005783; GO:0008285; GO:0048471; GO:0051533; GO:0051209 RNA binding; RNA processing; endoplasmic reticulum; negative regulation of cell proliferation; perinuclear region of cytoplasm; positive regulation of NFAT protein import into nucleus; release of sequestered calcium ion into cytosol IPR006569; IPR008942; IPR000467; IPR006903; IPR000061; Calcium homeostasis endoplasmic reticulum protein (SR-related CTD-associated factor 6) Cherp Scaf6 Mus musculus (Mouse) TR40469_c0_g2_i1 P36876 2ABA_RAT 9.00E-155 GO:0000159; GO:0008601; GO:0043278; GO:0007165 protein phosphatase type 2A complex; protein phosphatase type 2A regulator activity; response to morphine; signal transduction IPR000009; IPR018067; IPR015943; IPR001680; IPR017986; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (PP2A subunit B isoform BRA) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha) Ppp2r2a Rattus norvegicus (Rat) TR40469_c0_g2_i2 Q0E2P1 2ABB_ORYSJ 2.00E-78 GO:0000159; GO:0008601; GO:0007165 protein phosphatase type 2A complex; protein phosphatase type 2A regulator activity; signal transduction IPR000009; IPR018067; IPR015943; IPR001680; IPR017986; "Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A, subunit B, beta isoform)" Os02g0224200 LOC_Os02g13110 OsJ_005772 P0470A03.14 Oryza sativa subsp. japonica (Rice) TR40470_c1_g1_i1 Q05893 PCKG_ASCSU 5.00E-32 GO:0005525; GO:0006094; GO:0046872; GO:0004613 GTP binding; gluconeogenesis; metal ion binding; phosphoenolpyruvate carboxykinase (GTP) activity IPR018091; IPR013035; IPR008209; IPR008210; Phosphoenolpyruvate carboxykinase [GTP] (PEPCK) (EC 4.1.1.32) (Phosphoenolpyruvate carboxylase) PEPCK Ascaris suum (Pig roundworm) (Ascaris lumbricoides) TR40472_c1_g2_i2 Q6V0I7 FAT4_HUMAN 8.00E-12 GO:0005509; GO:0007156; GO:0016021; GO:0005886 Q9H2K2 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) TR40472_c1_g2_i3 Q6IN38 WIF1_RAT 1.00E-10 GO:0016055; GO:0005576; GO:0007275; GO:0045600 Wnt receptor signaling pathway; extracellular region; multicellular organismal development; positive regulation of fat cell differentiation IPR000742; IPR013032; IPR003306; IPR013309; Wnt inhibitory factor 1 (WIF-1) Wif1 Rattus norvegicus (Rat) TR40472_c1_g2_i4 Q14517 FAT1_HUMAN 1.00E-15 GO:0007015; GO:0009653; GO:0005509; GO:0016477; GO:0016337; GO:0005911; GO:0007267; GO:0007163; GO:0030175; GO:0007156; GO:0005887; GO:0030027; GO:0005634; GO:0048471 Q8N8S7; Q9NSC5; Q99JP6 actin filament organization; anatomical structure morphogenesis; calcium ion binding; cell migration; cell-cell adhesion; cell-cell junction; cell-cell signaling; establishment or maintenance of cell polarity; filopodium; homophilic cell adhesion; integral to plasma membrane; lamellipodium; nucleus; perinuclear region of cytoplasm IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) TR40472_c1_g2_i5 Q9W3W5 WIF1_DROME 6.00E-10 GO:0045880; GO:0050821; GO:0005578; GO:0007224; GO:0008039 positive regulation of smoothened signaling pathway; protein stabilization; proteinaceous extracellular matrix; smoothened signaling pathway; synaptic target recognition IPR000742; IPR013032; IPR003306; Protein shifted (WIF-1-like protein) shf CG3135 Drosophila melanogaster (Fruit fly) TR40474_c1_g1_i6 A1ZA47 ZASP_DROME 4.00E-14 GO:0030018; GO:0015629; GO:0051371; GO:0005927; GO:0030239; GO:0001952; GO:0008270 Z disc; actin cytoskeleton; muscle alpha-actinin binding; muscle tendon junction; myofibril assembly; regulation of cell-matrix adhesion; zinc ion binding IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) TR40474_c1_g1_i7 Q679P3 PDLI7_CHICK 2.00E-12 GO:0030018; GO:0030154; GO:0005856; GO:0007275; GO:0001503; GO:0008270 O93288; Q9PWE8 Z disc; cell differentiation; cytoskeleton; multicellular organismal development; ossification; zinc ion binding IPR001478; IPR001781; PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) PDLIM7 LMP RCJMB04_14g20 Gallus gallus (Chicken) TR40474_c1_g1_i8 A1ZA47 ZASP_DROME 3.00E-13 GO:0030018; GO:0015629; GO:0051371; GO:0005927; GO:0030239; GO:0001952; GO:0008270 Z disc; actin cytoskeleton; muscle alpha-actinin binding; muscle tendon junction; myofibril assembly; regulation of cell-matrix adhesion; zinc ion binding IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) TR40474_c1_g3_i1 Q3UHK8 TNR6A_MOUSE 9.00E-39 GO:0003723; GO:0009267; GO:0000932; GO:0032507; GO:0035068; GO:0035278; GO:0000166; GO:0048471; GO:1900153; GO:0060213; GO:0032947 "RNA binding; cellular response to starvation; cytoplasmic mRNA processing body; maintenance of protein location in cell; micro-ribonucleoprotein complex; negative regulation of translation involved in gene silencing by miRNA; nucleotide binding; perinuclear region of cytoplasm; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; protein complex scaffold" IPR019486; IPR026804; IPR012677; IPR000504; Trinucleotide repeat-containing gene 6A protein Tnrc6a Kiaa1460 Mus musculus (Mouse) TR40475_c4_g1_i1 Q04519 ASM_MOUSE 9.00E-18 GO:0016798; GO:0005764; GO:0043407; GO:0035307; GO:0006685; GO:0004767; GO:0023021 "hydrolase activity, acting on glycosyl bonds; lysosome; negative regulation of MAP kinase activity; positive regulation of protein dephosphorylation; sphingomyelin catabolic process; sphingomyelin phosphodiesterase activity; termination of signal transduction" IPR004843; IPR011001; IPR008139; IPR011160; Sphingomyelin phosphodiesterase (EC 3.1.4.12) (Acid sphingomyelinase) (aSMase) Smpd1 Asm Mus musculus (Mouse) TR40475_c4_g3_i1 Q23498 ASM2_CAEEL 5.00E-81 GO:0046513; GO:0005576; GO:0016798; GO:0005622; GO:0006685; GO:0004767 "ceramide biosynthetic process; extracellular region; hydrolase activity, acting on glycosyl bonds; intracellular; sphingomyelin catabolic process; sphingomyelin phosphodiesterase activity" IPR004843; IPR007856; IPR011001; IPR008139; IPR011160; Lipid metabolism; sphingolipid metabolism. Sphingomyelin phosphodiesterase 2 (EC 3.1.4.12) (Acid sphingomyelinase 2) asm-2 ZK455.4 Caenorhabditis elegans TR40475_c4_g3_i2 P17405 ASM_HUMAN 8.00E-112 GO:0008219; GO:0046513; GO:0005615; GO:0006687; GO:0016798; GO:0042599; GO:0043202; GO:0043407; GO:0007399; GO:0043065; GO:0035307; GO:0042220; GO:0042493; GO:0007165; GO:0006685; GO:0006684; GO:0004767; GO:0023021 P55210 "cell death; ceramide biosynthetic process; extracellular space; glycosphingolipid metabolic process; hydrolase activity, acting on glycosyl bonds; lamellar body; lysosomal lumen; negative regulation of MAP kinase activity; nervous system development; positive regulation of apoptotic process; positive regulation of protein dephosphorylation; response to cocaine; response to drug; signal transduction; sphingomyelin catabolic process; sphingomyelin metabolic process; sphingomyelin phosphodiesterase activity; termination of signal transduction" IPR004843; IPR011001; IPR008139; IPR011160; Sphingomyelin phosphodiesterase (EC 3.1.4.12) (Acid sphingomyelinase) (aSMase) SMPD1 ASM Homo sapiens (Human) TR40476_c0_g1_i2 P54001 P4HA1_RAT 3.00E-131 GO:0031418; GO:0030199; GO:0005788; GO:0005506; GO:0005739; GO:0016702; GO:0018401; GO:0004656 "L-ascorbic acid binding; collagen fibril organization; endoplasmic reticulum lumen; iron ion binding; mitochondrion; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; procollagen-proline 4-dioxygenase activity" IPR005123; IPR006620; IPR013547; IPR013026; IPR011990; IPR019734; "Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)" P4ha1 P4ha Rattus norvegicus (Rat) TR40476_c0_g1_i4 Q5UP57 P4H_MIMIV 1.00E-14 GO:0031418; GO:0005506; GO:0004656; GO:0019012 L-ascorbic acid binding; iron ion binding; procollagen-proline 4-dioxygenase activity; virion IPR005123; IPR006620; "Putative prolyl 4-hydroxylase (4-PH) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase)" MIMI_L593 Acanthamoeba polyphaga mimivirus (APMV) TR40476_c0_g1_i5 P54001 P4HA1_RAT 1.00E-131 GO:0031418; GO:0030199; GO:0005788; GO:0005506; GO:0005739; GO:0016702; GO:0018401; GO:0004656 "L-ascorbic acid binding; collagen fibril organization; endoplasmic reticulum lumen; iron ion binding; mitochondrion; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; procollagen-proline 4-dioxygenase activity" IPR005123; IPR006620; IPR013547; IPR013026; IPR011990; IPR019734; "Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)" P4ha1 P4ha Rattus norvegicus (Rat) TR40478_c1_g1_i1 Q6CUA5 PNO1_KLULA 1.00E-78 GO:0003723; GO:0005737; GO:0005730; GO:0042254 RNA binding; cytoplasm; nucleolus; ribosome biogenesis IPR004087; Pre-rRNA-processing protein PNO1 PNO1 KLLA0C06446g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR40478_c1_g1_i2 Q8AVH4 PNO1_XENLA 4.00E-98 GO:0003723; GO:0005730 RNA binding; nucleolus IPR004087; IPR004088; RNA-binding protein PNO1 pno1 Xenopus laevis (African clawed frog) TR40480_c2_g3_i1 Q13263 TIF1B_HUMAN 3.00E-10 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR40480_c2_g3_i15 Q1PSW8 LIN41_MOUSE 2.00E-09 GO:0000082; GO:0000932; GO:0008543; GO:0035198; GO:0010586; GO:0035278; GO:0001843; GO:2000637; GO:0051865; GO:2000177; GO:0072089; GO:0004842; GO:0008270 G1/S transition of mitotic cell cycle; cytoplasmic mRNA processing body; fibroblast growth factor receptor signaling pathway; miRNA binding; miRNA metabolic process; negative regulation of translation involved in gene silencing by miRNA; neural tube closure; positive regulation of gene silencing by miRNA; protein autoubiquitination; regulation of neural precursor cell proliferation; stem cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (mLin41) (Tripartite motif-containing protein 71) Trim71 Gm1127 Lin41 Mus musculus (Mouse) TR40480_c2_g3_i2 Q13263 TIF1B_HUMAN 1.00E-10 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR40480_c2_g3_i4 Q6E2N3 TRI33_DANRE 7.00E-06 GO:0003677; GO:0016874; GO:0005634; GO:0016567; GO:0006355; GO:0006351; GO:0008270 "DNA binding; ligase activity; nucleus; protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (Protein moonshine) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 mon Danio rerio (Zebrafish) (Brachydanio rerio) TR40482_c0_g1_i1 Q5ZK95 CCD43_CHICK 7.00E-12 Coiled-coil domain-containing protein 43 CCDC43 RCJMB04_12d20 Gallus gallus (Chicken) TR40482_c1_g1_i2 Q8N5Y2 MS3L1_HUMAN 1.00E-25 GO:0003677; GO:0072487; GO:0043984; GO:0035064; GO:0007275; GO:0003700; GO:0006366 DNA binding; MSL complex; histone H4-K16 acetylation; methylated histone residue binding; multicellular organismal development; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter IPR000953; IPR016197; IPR008676; IPR026541; IPR025995; Male-specific lethal 3 homolog (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) MSL3 MSL3L1 Homo sapiens (Human) TR40482_c1_g1_i3 Q6C9M9 EAF3_YARLI 1.00E-05 GO:0006281; GO:0016568; GO:0005634; GO:0006355; GO:0006351 "DNA repair; chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000953; IPR016197; IPR008676; IPR026541; IPR025995; Chromatin modification-related protein EAF3 EAF3 YALI0D09845g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR40483_c0_g2_i11 Q05793 PGBM_MOUSE 1.00E-06 GO:0005796; GO:0001525; GO:0005605; GO:0007420; GO:0048738; GO:0060351; GO:0002062; GO:0048704; GO:0001958; GO:0030198; GO:0046872; GO:0008104 Golgi lumen; angiogenesis; basal lamina; brain development; cardiac muscle tissue development; cartilage development involved in endochondral bone morphogenesis; chondrocyte differentiation; embryonic skeletal system morphogenesis; endochondral ossification; extracellular matrix organization; metal ion binding; protein localization IPR008985; IPR013320; IPR000742; IPR013032; IPR002049; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR018031; IPR000034; IPR001791; IPR023415; IPR002172; IPR000082; Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) [Cleaved into: Endorepellin; LG3 peptide] Hspg2 Mus musculus (Mouse) TR40483_c0_g2_i3 Q26474 LACH_SCHAM 2.00E-06 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Lachesin LAC Schistocerca americana (American grasshopper) TR40483_c0_g2_i6 Q7ZW34 CNTN5_DANRE 7.00E-06 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Contactin-5 cntn5 zgc:55318 Danio rerio (Zebrafish) (Brachydanio rerio) TR40484_c3_g1_i1 Q66JV4 R12BB_MOUSE 3.00E-19 GO:0003723; GO:0000166 RNA binding; nucleotide binding IPR012677; IPR000504; RNA-binding protein 12B-B (RNA-binding motif protein 12B-B) Rbm12b2 Rbm12bb Mus musculus (Mouse) TR40484_c4_g1_i1 Q5RBM8 RBM12_PONAB 1.00E-18 GO:0003723; GO:0000166; GO:0005634 RNA binding; nucleotide binding; nucleus IPR012677; IPR000504; RNA-binding protein 12 (RNA-binding motif protein 12) RBM12 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40484_c4_g3_i1 Q5ZLR4 ESRP2_CHICK 9.00E-14 GO:0008380; GO:0003729; GO:0006397; GO:0000166; GO:0005634; GO:0043484 RNA splicing; mRNA binding; mRNA processing; nucleotide binding; nucleus; regulation of RNA splicing IPR012677; IPR012337; IPR000504; Epithelial splicing regulatory protein 2 (RNA-binding motif protein 35B) (RNA-binding protein 35B) ESRP2 RBM35B RCJMB04_5c3 Gallus gallus (Chicken) TR40484_c4_g3_i2 Q9NTZ6 RBM12_HUMAN 9.00E-17 GO:0003723; GO:0000166; GO:0005634 RNA binding; nucleotide binding; nucleus IPR012677; IPR000504; RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN) RBM12 KIAA0765 HRIHFB2091 Homo sapiens (Human) TR40486_c0_g2_i2 Q8BTV1 TUSC3_MOUSE 2.00E-134 GO:0045454; GO:0050890; GO:0016021; GO:0015095; GO:0005739; GO:0008250; GO:0018279 cell redox homeostasis; cognition; integral to membrane; magnesium ion transmembrane transporter activity; mitochondrion; oligosaccharyltransferase complex; protein N-linked glycosylation via asparagine IPR006844; IPR021149; IPR012336; IPR013766; Tumor suppressor candidate 3 (Magnesium uptake/transporter TUSC3) (Protein N33) Tusc3 N33 Mus musculus (Mouse) TR40486_c0_g2_i5 Q8BTV1 TUSC3_MOUSE 1.00E-89 GO:0045454; GO:0050890; GO:0016021; GO:0015095; GO:0005739; GO:0008250; GO:0018279 cell redox homeostasis; cognition; integral to membrane; magnesium ion transmembrane transporter activity; mitochondrion; oligosaccharyltransferase complex; protein N-linked glycosylation via asparagine IPR006844; IPR021149; IPR012336; IPR013766; Tumor suppressor candidate 3 (Magnesium uptake/transporter TUSC3) (Protein N33) Tusc3 N33 Mus musculus (Mouse) TR40487_c0_g1_i2 Q803M3 TEX10_DANRE 4.00E-57 GO:0071339; GO:0016021; GO:0031965; GO:0005730 MLL1 complex; integral to membrane; nuclear membrane; nucleolus IPR011989; IPR016024; IPR024679; Testis-expressed sequence 10 protein homolog tex10 zgc:55523 Danio rerio (Zebrafish) (Brachydanio rerio) TR40488_c2_g2_i1 Q5ZI20 S39AD_CHICK 1.00E-64 GO:0000139; GO:0006882; GO:0061448; GO:0016021; GO:0046873; GO:0048471; GO:0071577 Golgi membrane; cellular zinc ion homeostasis; connective tissue development; integral to membrane; metal ion transmembrane transporter activity; perinuclear region of cytoplasm; zinc ion transmembrane transport IPR003689; Zinc transporter ZIP13 (Solute carrier family 39 member 13) (Zrt- and Irt-like protein 13) (ZIP-13) SLC39A13 ZIP13 RCJMB04_31f18 Gallus gallus (Chicken) TR40489_c0_g1_i1 Q64691 CAN3_MOUSE 1.00E-95 GO:0070315; GO:0030315; GO:0030018; GO:0001896; GO:0005509; GO:0004198; GO:0071277; GO:0071472; GO:0005829; GO:0055103; GO:0043066; GO:0033234; GO:0045892; GO:0005634; GO:0051092; GO:0045862; GO:0051281; GO:0014718; GO:0045893; GO:0043234; GO:0006461; GO:0032947; GO:0072657; GO:0043122; GO:0045661; GO:0014850; GO:0045214; GO:0097264; GO:0031402; GO:0008307; GO:0031432 "G1 to G0 transition involved in cell differentiation; T-tubule; Z disc; autolysis; calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cellular response to calcium ion; cellular response to salt stress; cytosol; ligase regulator activity; negative regulation of apoptotic process; negative regulation of protein sumoylation; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of proteolysis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of satellite cell activation involved in skeletal muscle regeneration; positive regulation of transcription, DNA-dependent; protein complex; protein complex assembly; protein complex scaffold; protein localization to membrane; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of myoblast differentiation; response to muscle activity; sarcomere organization; self proteolysis; sodium ion binding; structural constituent of muscle; titin binding" IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) Capn3 Mus musculus (Mouse) TR40489_c0_g1_i2 O08688 CAN5_MOUSE 0 GO:0004198; GO:0009986; GO:0005622; GO:0006508 calcium-dependent cysteine-type endopeptidase activity; cell surface; intracellular; proteolysis IPR000008; IPR022684; IPR022682; IPR022683; IPR000169; IPR001300; Calpain-5 (EC 3.4.22.-) (New calpain 3) (nCL-3) Capn5 Ncl3 Mus musculus (Mouse) TR40490_c1_g1_i1 O13010 PI42A_PIG 2.00E-34 GO:0016309; GO:0005524; GO:0005737; GO:0005634; GO:0046854; GO:0005886 1-phosphatidylinositol-5-phosphate 4-kinase activity; ATP binding; cytoplasm; nucleus; phosphatidylinositol phosphorylation; plasma membrane IPR023610; IPR027483; IPR002498; IPR027484; IPR016034; Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(5)P-4-kinase isoform 2-alpha) PIP4K2A PIP5K2A Sus scrofa (Pig) TR40490_c1_g1_i2 P70182 PI51A_MOUSE 0 GO:0016308; GO:0005524; GO:0031532; GO:0032863; GO:0060326; GO:0005737; GO:0010761; GO:0048041; GO:0030027; GO:0005847; GO:0016607; GO:0005634; GO:0008654; GO:0072661; GO:0097178; GO:0032587 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding; actin cytoskeleton reorganization; activation of Rac GTPase activity; cell chemotaxis; cytoplasm; fibroblast migration; focal adhesion assembly; lamellipodium; mRNA cleavage and polyadenylation specificity factor complex; nuclear speck; nucleus; phospholipid biosynthetic process; protein targeting to plasma membrane; ruffle assembly; ruffle membrane IPR023610; IPR027483; IPR002498; IPR027484; IPR016034; Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) (Phosphatidylinositol 4-phosphate 5-kinase type I beta) (PI4P5KIbeta) Pip5k1a Pip5k1b Mus musculus (Mouse) TR40490_c1_g1_i4 O14986 PI51B_HUMAN 7.00E-138 GO:0016308; GO:0005524; GO:0005829; GO:0012505; GO:0016020; GO:0006661; GO:0044281; GO:0001931 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding; cytosol; endomembrane system; membrane; phosphatidylinositol biosynthetic process; small molecule metabolic process; uropod IPR023610; IPR027483; IPR002498; IPR027484; IPR016034; Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1-beta) (PtdIns(4)P-5-kinase 1 beta) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I beta) (PIP5KIbeta) (Protein STM-7) (Type I phosphatidylinositol 4-phosphate 5-kinase beta) PIP5K1B STM7 Homo sapiens (Human) TR40491_c0_g1_i1 P97584 PTGR1_RAT 3.00E-59 GO:0036132; GO:0047522; GO:0032440; GO:0005737; GO:0006693; GO:0009636; GO:0008270 13-prostaglandin reductase activity; 15-oxoprostaglandin 13-oxidase activity; 2-alkenal reductase [NAD(P)] activity; cytoplasm; prostaglandin metabolic process; response to toxic substance; zinc ion binding IPR013149; IPR002085; IPR014190; IPR011032; IPR016040; Prostaglandin reductase 1 (PRG-1) (EC 1.3.1.-) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (Dithiolethione-inducible gene 1 protein) (D3T-inducible gene 1 protein) (DIG-1) (NADP-dependent leukotriene B4 12-hydroxydehydrogenase) (EC 1.3.1.74) Ptgr1 Dig1 Ltb4dh Rattus norvegicus (Rat) TR40491_c0_g1_i2 Q5R806 PTGR2_PONAB 3.00E-38 GO:0036132; GO:0047522; GO:0005737; GO:0006693 13-prostaglandin reductase activity; 15-oxoprostaglandin 13-oxidase activity; cytoplasm; prostaglandin metabolic process IPR013149; IPR002085; IPR011032; IPR016040; Prostaglandin reductase 2 (PRG-2) (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase) PTGR2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40491_c0_g2_i3 P16423 POLR_DROME 1.00E-08 GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0046872; GO:0090305; GO:0006508 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR000477; IPR007087; IPR015880; Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM (Retrovirus-related Pol polyprotein from type II retrotransposable element R2DM) [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR40491_c0_g6_i1 P97584 PTGR1_RAT 3.00E-38 GO:0036132; GO:0047522; GO:0032440; GO:0005737; GO:0006693; GO:0009636; GO:0008270 13-prostaglandin reductase activity; 15-oxoprostaglandin 13-oxidase activity; 2-alkenal reductase [NAD(P)] activity; cytoplasm; prostaglandin metabolic process; response to toxic substance; zinc ion binding IPR013149; IPR002085; IPR014190; IPR011032; IPR016040; Prostaglandin reductase 1 (PRG-1) (EC 1.3.1.-) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (Dithiolethione-inducible gene 1 protein) (D3T-inducible gene 1 protein) (DIG-1) (NADP-dependent leukotriene B4 12-hydroxydehydrogenase) (EC 1.3.1.74) Ptgr1 Dig1 Ltb4dh Rattus norvegicus (Rat) TR40493_c0_g1_i1 Q9LVH5 OE64C_ARATH 5.00E-18 GO:0016884; GO:0031359; GO:0015031 "carbon-nitrogen ligase activity, with glutamine as amido-N-donor; integral to chloroplast outer membrane; protein transport" IPR000120; IPR023631; IPR013026; IPR011990; IPR001440; IPR019734; "Outer envelope protein 64, chloroplastic (Translocon at the outer membrane of chloroplasts 64-III)" OEP64 TOC64-III At3g17970 MEB5.19 Arabidopsis thaliana (Mouse-ear cress) TR40493_c1_g1_i1 Q9VL78 FKB59_DROME 1.00E-14 GO:0005528; GO:0050908; GO:0016027; GO:0003755; GO:0007422; GO:0006457; GO:0051924 FK506 binding; detection of light stimulus involved in visual perception; inaD signaling complex; peptidyl-prolyl cis-trans isomerase activity; peripheral nervous system development; protein folding; regulation of calcium ion transport IPR023566; IPR001179; IPR013026; IPR011990; IPR001440; IPR019734; FK506-binding protein 59 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (dFKBP59) FKBP59 CG4535 Drosophila melanogaster (Fruit fly) TR40493_c1_g1_i2 Q3KRD5 TOM34_RAT 4.00E-45 GO:0005741; GO:0006626 mitochondrial outer membrane; protein targeting to mitochondrion IPR013026; IPR011990; IPR001440; IPR019734; Mitochondrial import receptor subunit TOM34 (Translocase of outer membrane 34 kDa subunit) Tomm34 Rattus norvegicus (Rat) TR40493_c1_g1_i3 Q07617 SPAG1_HUMAN 7.00E-41 GO:0005525; GO:0005737; GO:0016787; GO:0007338 GTP binding; cytoplasm; hydrolase activity; single fertilization IPR025986; IPR013026; IPR011990; IPR001440; IPR019734; Sperm-associated antigen 1 (HSD-3.8) (Infertility-related sperm protein Spag-1) SPAG1 Homo sapiens (Human) TR40493_c1_g1_i4 Q96EQ0 SGTB_HUMAN 2.00E-12 IPR013026; IPR011990; IPR001440; IPR019734; Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) SGTB SGT2 Homo sapiens (Human) TR40493_c1_g1_i5 Q3KRD5 TOM34_RAT 2.00E-48 GO:0005741; GO:0006626 mitochondrial outer membrane; protein targeting to mitochondrion IPR013026; IPR011990; IPR001440; IPR019734; Mitochondrial import receptor subunit TOM34 (Translocase of outer membrane 34 kDa subunit) Tomm34 Rattus norvegicus (Rat) TR40496_c0_g2_i1 Q9M1H3 AB4F_ARATH 4.00E-144 GO:0005524; GO:0006200; GO:0016887; GO:0005215 ATP binding; ATP catabolic process; ATPase activity; transporter activity IPR003593; IPR003439; IPR017871; IPR027417; ABC transporter F family member 4 (ABC transporter ABCF.4) (AtABCF4) (GCN20-type ATP-binding cassette protein GCN4) ABCF4 GCN4 At3g54540 T14E10.110 Arabidopsis thaliana (Mouse-ear cress) TR40496_c0_g2_i2 Q99LE6 ABCF2_MOUSE 0 GO:0005524; GO:0006200; GO:0016887; GO:0005739 ATP binding; ATP catabolic process; ATPase activity; mitochondrion IPR003593; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family F member 2 Abcf2 Mus musculus (Mouse) TR40496_c0_g2_i3 D5AQY6 NIKO_RHOCB 2.00E-08 GO:0005524; GO:0006200; GO:0043190; GO:0016887; GO:0015675; GO:0005886 ATP binding; ATP catabolic process; ATP-binding cassette (ABC) transporter complex; ATPase activity; nickel cation transport; plasma membrane IPR003593; IPR003439; IPR017871; IPR027417; Nickel import ATP-binding protein NikO (EC 3.6.3.-) (Energy-coupling factor transporter ATP-binding protein NikO) (ECF transporter A component NikO) nikO cbiO2 RCAP_rcc01032 Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) TR40496_c0_g2_i5 Q99LE6 ABCF2_MOUSE 0 GO:0005524; GO:0006200; GO:0016887; GO:0005739 ATP binding; ATP catabolic process; ATPase activity; mitochondrion IPR003593; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family F member 2 Abcf2 Mus musculus (Mouse) TR40496_c0_g2_i6 Q6D4A8 ZNUC_ERWCT 5.00E-20 GO:0005524; GO:0006200; GO:0016887; GO:0005886; GO:0015633 ATP binding; ATP catabolic process; ATPase activity; plasma membrane; zinc transporting ATPase activity IPR003593; IPR003439; IPR017882; IPR027417; Zinc import ATP-binding protein ZnuC (EC 3.6.3.-) znuC ECA2485 Erwinia carotovora subsp. atroseptica (strain SCRI 1043 / ATCC BAA-672) (Pectobacterium atrosepticum) TR40498_c0_g1_i1 Q1JPX3 SYFA_DANRE 0 GO:0005524; GO:0005737; GO:0004826; GO:0006432; GO:0000049 ATP binding; cytoplasm; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding IPR006195; IPR004529; IPR002319; IPR011991; Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) farsa farsla zgc:136506 zgc:158185 Danio rerio (Zebrafish) (Brachydanio rerio) TR40498_c0_g1_i10 Q1JPX3 SYFA_DANRE 0 GO:0005524; GO:0005737; GO:0004826; GO:0006432; GO:0000049 ATP binding; cytoplasm; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding IPR006195; IPR004529; IPR002319; IPR011991; Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) farsa farsla zgc:136506 zgc:158185 Danio rerio (Zebrafish) (Brachydanio rerio) TR40498_c0_g1_i11 P15625 SYFA_YEAST 3.00E-154 GO:0005524; GO:0004826; GO:0009328; GO:0006432; GO:0000049 P15624 ATP binding; phenylalanine-tRNA ligase activity; phenylalanine-tRNA ligase complex; phenylalanyl-tRNA aminoacylation; tRNA binding IPR006195; IPR004529; IPR002319; Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) FRS2 YFL022C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40498_c0_g1_i3 B7XI98 SYFA_ENTBH 3.00E-127 GO:0005524; GO:0005737; GO:0004826; GO:0006432; GO:0000049 ATP binding; cytoplasm; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding IPR006195; IPR004529; IPR002319; Probable phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) EBI_22775 Enterocytozoon bieneusi (strain H348) (Microsporidian parasite) TR40498_c0_g1_i4 Q5ZJQ2 SYFA_CHICK 0 GO:0005524; GO:0005737; GO:0004826; GO:0006432; GO:0000049 ATP binding; cytoplasm; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding IPR006195; IPR004529; IPR002319; Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) FARSA FARSLA RCJMB04_16g22 Gallus gallus (Chicken) TR40498_c0_g1_i5 Q54KS8 SYFA_DICDI 3.00E-165 GO:0005524; GO:0004826; GO:0009328; GO:0006432; GO:0000049 ATP binding; phenylalanine-tRNA ligase activity; phenylalanine-tRNA ligase complex; phenylalanyl-tRNA aminoacylation; tRNA binding IPR006195; IPR004529; IPR002319; Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) phesA pheS DDB_G0287141 Dictyostelium discoideum (Slime mold) TR40498_c0_g1_i6 Q9W3J5 SYFA_DROME 0 GO:0005524; GO:0005737; GO:0004826; GO:0006432; GO:0000049 ATP binding; cytoplasm; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding IPR006195; IPR004529; IPR002319; Probable phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) CG2263 Drosophila melanogaster (Fruit fly) TR40498_c0_g1_i7 Q9T034 SYFA_ARATH 0 GO:0005524; GO:0005829; GO:0004826; GO:0006432; GO:0000049 ATP binding; cytosol; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding IPR006195; IPR004529; IPR002319; Probable phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) At4g39280 T22F8.180 Arabidopsis thaliana (Mouse-ear cress) TR40499_c0_g1_i2 P49916 DNLI3_HUMAN 0 GO:0005524; GO:0003677; GO:0003910; GO:0051103; GO:0006284; GO:0051301; GO:0005694; GO:0006303; GO:0006273; GO:0043504; GO:0045910; GO:0005654; GO:0006289; GO:0007131; GO:0007283; GO:0000795; GO:0008270 ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligation involved in DNA repair; base-excision repair; cell division; chromosome; double-strand break repair via nonhomologous end joining; lagging strand elongation; mitochondrial DNA repair; negative regulation of DNA recombination; nucleoplasm; nucleotide-excision repair; reciprocal meiotic recombination; spermatogenesis; synaptonemal complex; zinc ion binding IPR001357; IPR000977; IPR012309; IPR012310; IPR016059; IPR012308; IPR012340; IPR001510; DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) LIG3 Homo sapiens (Human) TR40499_c0_g1_i3 O57250 DNLI_VACCA 7.00E-24 GO:0005524; GO:0003677; GO:0003910; GO:0051103; GO:0006310; GO:0006260; GO:0007049; GO:0051301; GO:0046872 ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligation involved in DNA repair; DNA recombination; DNA replication; cell cycle; cell division; metal ion binding IPR000977; IPR012309; IPR012310; IPR016059; IPR012308; IPR012340; DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP]) LIG MVA163R ACAM3000_MVA_163 Vaccinia virus (strain Ankara) (VACV) TR40499_c0_g1_i5 P49916 DNLI3_HUMAN 5.00E-52 GO:0005524; GO:0003677; GO:0003910; GO:0051103; GO:0006284; GO:0051301; GO:0005694; GO:0006303; GO:0006273; GO:0043504; GO:0045910; GO:0005654; GO:0006289; GO:0007131; GO:0007283; GO:0000795; GO:0008270 ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligation involved in DNA repair; base-excision repair; cell division; chromosome; double-strand break repair via nonhomologous end joining; lagging strand elongation; mitochondrial DNA repair; negative regulation of DNA recombination; nucleoplasm; nucleotide-excision repair; reciprocal meiotic recombination; spermatogenesis; synaptonemal complex; zinc ion binding IPR001357; IPR000977; IPR012309; IPR012310; IPR016059; IPR012308; IPR012340; IPR001510; DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) LIG3 Homo sapiens (Human) TR40500_c0_g1_i4 Q7TSV3 ZMY19_RAT 5.00E-83 GO:0005794; GO:0046872; GO:0005886; GO:0045202 Golgi apparatus; metal ion binding; plasma membrane; synapse IPR003615; IPR002893; Zinc finger MYND domain-containing protein 19 (Melanin-concentrating hormone receptor 1-interacting zinc finger protein) (MCH-R1-interacting zinc finger protein) Zmynd19 Mizip Rattus norvegicus (Rat) TR40501_c0_g2_i2 P42893 ECE1_RAT 3.00E-67 GO:0006915; GO:0005769; GO:0009897; GO:0016021; GO:0046872; GO:0004222; GO:0045745; GO:0030819; GO:0010613; GO:0001921; GO:0042803; GO:0016485; GO:0006508; GO:0070372; GO:0008217; GO:0042312; GO:0046686; GO:0042493; GO:0001666; GO:0035994; GO:0030141 apoptotic process; early endosome; external side of plasma membrane; integral to membrane; metal ion binding; metalloendopeptidase activity; positive regulation of G-protein coupled receptor protein signaling pathway; positive regulation of cAMP biosynthetic process; positive regulation of cardiac muscle hypertrophy; positive regulation of receptor recycling; protein homodimerization activity; protein processing; proteolysis; regulation of ERK1 and ERK2 cascade; regulation of blood pressure; regulation of vasodilation; response to cadmium ion; response to drug; response to hypoxia; response to muscle stretch; secretory granule IPR024079; IPR000718; IPR018497; IPR008753; Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) Ece1 Rattus norvegicus (Rat) TR40501_c0_g2_i4 Q18673 NEPL1_CAEEL 5.00E-10 GO:0016021; GO:0046872; GO:0004222; GO:0006508 integral to membrane; metal ion binding; metalloendopeptidase activity; proteolysis IPR024079; IPR000718; IPR018497; IPR008753; Neprilysin-1 (EC 3.4.24.-) nep-1 ZK20.6 Caenorhabditis elegans TR40501_c0_g3_i1 P97739 ECE1_CAVPO 5.00E-23 GO:0016021; GO:0046872; GO:0004222; GO:0005886; GO:0006508 integral to membrane; metal ion binding; metalloendopeptidase activity; plasma membrane; proteolysis IPR024079; IPR000718; IPR018497; IPR008753; Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) ECE1 Cavia porcellus (Guinea pig) TR40502_c1_g1_i1 Q9VPQ6 USH_DROME 1.00E-20 GO:0003677; GO:0046665; GO:0022416; GO:0048749; GO:0007393; GO:0007398; GO:0007390; GO:0008258; GO:0007507; GO:0035167; GO:0046872; GO:0009996; GO:0042690; GO:0043433; GO:0000122; GO:0005634; GO:0042440; GO:0002805; GO:0007362; GO:0008293; GO:0008134; GO:0006351 "DNA binding; amnioserosa maintenance; chaeta development; compound eye development; dorsal closure, leading edge cell fate determination; ectoderm development; germ-band shortening; head involution; heart development; larval lymph gland hemopoiesis; metal ion binding; negative regulation of cell fate specification; negative regulation of crystal cell differentiation; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; nucleus; pigment metabolic process; regulation of antimicrobial peptide biosynthetic process; terminal region determination; torso signaling pathway; transcription factor binding; transcription, DNA-dependent" IPR007087; IPR015880; Zinc finger protein ush (Protein U-shaped) ush CG2762 Drosophila melanogaster (Fruit fly) TR40502_c1_g2_i1 O35615 FOG1_MOUSE 7.00E-08 GO:0003677; GO:0001102; GO:0001078; GO:0060413; GO:0003181; GO:0055008; GO:0005737; GO:0060318; GO:0030851; GO:0035855; GO:0046872; GO:0003192; GO:0045599; GO:0045403; GO:0060377; GO:0032091; GO:0000122; GO:0005634; GO:0003151; GO:0030220; GO:0045078; GO:0060319; GO:0032642; GO:0010724; GO:0003714; GO:0005667; GO:0071733; GO:0017053; GO:0003195; GO:0060412 Q9JJ11 DNA binding; RNA polymerase II activating transcription factor binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; atrial septum morphogenesis; atrioventricular valve morphogenesis; cardiac muscle tissue morphogenesis; cytoplasm; definitive erythrocyte differentiation; granulocyte differentiation; megakaryocyte development; metal ion binding; mitral valve formation; negative regulation of fat cell differentiation; negative regulation of interleukin-4 biosynthetic process; negative regulation of mast cell differentiation; negative regulation of protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; outflow tract morphogenesis; platelet formation; positive regulation of interferon-gamma biosynthetic process; primitive erythrocyte differentiation; regulation of chemokine production; regulation of definitive erythrocyte differentiation; transcription corepressor activity; transcription factor complex; transcriptional activation by promoter-enhancer looping; transcriptional repressor complex; tricuspid valve formation; ventricular septum morphogenesis IPR007087; IPR015880; IPR013087; Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein multitype 1) Zfpm1 Fog Fog1 Mus musculus (Mouse) TR40503_c1_g1_i1 O15118 NPC1_HUMAN 0 GO:0005794; GO:0007628; GO:0006914; GO:0008206; GO:0071404; GO:0071383; GO:0015485; GO:0033344; GO:0042632; GO:0008203; GO:0006897; GO:0005783; GO:0005576; GO:0008158; GO:0005887; GO:0031902; GO:0005765; GO:0007041; GO:0045121; GO:0016242; GO:0005635; GO:0048471; GO:0006486; GO:0042493; GO:0015248; GO:0004888; GO:0031982 Golgi apparatus; adult walking behavior; autophagy; bile acid metabolic process; cellular response to low-density lipoprotein particle stimulus; cellular response to steroid hormone stimulus; cholesterol binding; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; endocytosis; endoplasmic reticulum; extracellular region; hedgehog receptor activity; integral to plasma membrane; late endosome membrane; lysosomal membrane; lysosomal transport; membrane raft; negative regulation of macroautophagy; nuclear envelope; perinuclear region of cytoplasm; protein glycosylation; response to drug; sterol transporter activity; transmembrane signaling receptor activity; vesicle IPR004765; IPR003392; IPR000731; Niemann-Pick C1 protein NPC1 Homo sapiens (Human) TR40503_c1_g1_i2 Q90693 PTC1_CHICK 4.00E-30 GO:0008158; GO:0005887; GO:0007224 hedgehog receptor activity; integral to plasma membrane; smoothened signaling pathway IPR003392; IPR000731; IPR004766; Protein patched homolog 1 (PTC) (PTC1) PTCH1 PTC PTCH Gallus gallus (Chicken) TR40503_c1_g1_i3 Q0EEE2 PTHD3_MOUSE 4.00E-26 GO:0008158; GO:0016021 hedgehog receptor activity; integral to membrane IPR003392; IPR000731; Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) TR40503_c1_g1_i4 P56941 NPC1_PIG 0 GO:0008206; GO:0015485; GO:0042632; GO:0008203; GO:0030301; GO:0005783; GO:0005576; GO:0008158; GO:0005887; GO:0031902; GO:0005765; GO:0007041; GO:0005764; GO:0005635; GO:0048471; GO:0006486 bile acid metabolic process; cholesterol binding; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; endoplasmic reticulum; extracellular region; hedgehog receptor activity; integral to plasma membrane; late endosome membrane; lysosomal membrane; lysosomal transport; lysosome; nuclear envelope; perinuclear region of cytoplasm; protein glycosylation IPR004765; IPR003392; IPR000731; Niemann-Pick C1 protein NPC1 Sus scrofa (Pig) TR40506_c0_g1_i6 P54071 IDHP_MOUSE 0 GO:0006103; GO:0051287; GO:0006097; GO:0004450; GO:0006102; GO:0000287; GO:0005743; GO:0006950; GO:0006099 2-oxoglutarate metabolic process; NAD binding; glyoxylate cycle; isocitrate dehydrogenase (NADP+) activity; isocitrate metabolic process; magnesium ion binding; mitochondrial inner membrane; response to stress; tricarboxylic acid cycle IPR019818; IPR004790; IPR024084; "Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)" Idh2 Mus musculus (Mouse) TR40506_c0_g1_i7 P54071 IDHP_MOUSE 0 GO:0006103; GO:0051287; GO:0006097; GO:0004450; GO:0006102; GO:0000287; GO:0005743; GO:0006950; GO:0006099 2-oxoglutarate metabolic process; NAD binding; glyoxylate cycle; isocitrate dehydrogenase (NADP+) activity; isocitrate metabolic process; magnesium ion binding; mitochondrial inner membrane; response to stress; tricarboxylic acid cycle IPR019818; IPR004790; IPR024084; "Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)" Idh2 Mus musculus (Mouse) TR40506_c0_g1_i8 P41019 LEU3_BACMD 6.00E-07 GO:0003862; GO:0051287; GO:0005737; GO:0009098; GO:0000287 3-isopropylmalate dehydrogenase activity; NAD binding; cytoplasm; leucine biosynthetic process; magnesium ion binding IPR019818; IPR001804; IPR024084; IPR004429; Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4. 3-isopropylmalate dehydrogenase (EC 1.1.1.85) (3-IPM-DH) (Beta-IPM dehydrogenase) (IMDH) leuB leuC BMD_4682 Bacillus megaterium (strain DSM 319) TR40507_c0_g2_i1 Q5R7R6 COG4_PONAB 0 GO:0000139; GO:0015031 Golgi membrane; protein transport IPR013167; Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4) COG4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40507_c0_g2_i3 Q5R7R6 COG4_PONAB 0 GO:0000139; GO:0015031 Golgi membrane; protein transport IPR013167; Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4) COG4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40507_c0_g2_i5 Q8L838 COG4_ARATH 3.00E-125 GO:0000139; GO:0015031 Golgi membrane; protein transport IPR013167; Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4) COG4 At4g01395 F3D13.1 Arabidopsis thaliana (Mouse-ear cress) TR40508_c0_g2_i1 Q14149 MORC3_HUMAN 2.00E-59 GO:0005524; GO:0016605; GO:0016235; GO:0007569; GO:0045111; GO:0051457; GO:0048147; GO:0018105; GO:0009791; GO:0050821; GO:0008270 ATP binding; PML body; aggresome; cell aging; intermediate filament cytoskeleton; maintenance of protein location in nucleus; negative regulation of fibroblast proliferation; peptidyl-serine phosphorylation; post-embryonic development; protein stabilization; zinc ion binding IPR003594; IPR011124; MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled-coil domain protein 3) MORC3 KIAA0136 ZCWCC3 Homo sapiens (Human) TR40508_c2_g3_i1 Q14149 MORC3_HUMAN 1.00E-21 GO:0005524; GO:0016605; GO:0016235; GO:0007569; GO:0045111; GO:0051457; GO:0048147; GO:0018105; GO:0009791; GO:0050821; GO:0008270 ATP binding; PML body; aggresome; cell aging; intermediate filament cytoskeleton; maintenance of protein location in nucleus; negative regulation of fibroblast proliferation; peptidyl-serine phosphorylation; post-embryonic development; protein stabilization; zinc ion binding IPR003594; IPR011124; MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled-coil domain protein 3) MORC3 KIAA0136 ZCWCC3 Homo sapiens (Human) TR40509_c1_g1_i2 Q2M3M2 SC5A9_HUMAN 1.00E-13 GO:0016021; GO:0005886; GO:0006814; GO:0055085; GO:0005215 integral to membrane; plasma membrane; sodium ion transport; transmembrane transport; transporter activity IPR001734; IPR018212; IPR019900; Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (hSGLT4) (Solute carrier family 5 member 9) SLC5A9 SGLT4 Homo sapiens (Human) TR40509_c1_g1_i3 P26429 SC5A1_PIG 1.00E-14 GO:0008643; GO:0016021; GO:0006814; GO:0015293 carbohydrate transport; integral to membrane; sodium ion transport; symporter activity IPR001734; IPR018212; IPR019900; Sodium/glucose cotransporter 1 (Na(+)/glucose cotransporter 1) (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1) (Fragment) SLC5A1 SGLT1 Sus scrofa (Pig) TR40509_c1_g1_i4 Q8N8M0 NAT16_HUMAN 2.00E-14 GO:0008080 N-acetyltransferase activity IPR016181; IPR000182; Putative N-acetyltransferase 16 (EC 2.3.1.-) NAT16 C7orf52 Homo sapiens (Human) TR40513_c0_g1_i1 Q4TVV3 DDX46_DANRE 0 GO:0005524; GO:0008026; GO:0015030; GO:0003723; GO:0008380; GO:0006397; GO:0016607 ATP binding; ATP-dependent helicase activity; Cajal body; RNA binding; RNA splicing; mRNA processing; nuclear speck IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) ddx46 Danio rerio (Zebrafish) (Brachydanio rerio) TR40513_c0_g1_i3 P71359 RECQ_HAEIN 8.00E-07 GO:0005524; GO:0043140; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0009432; GO:0005622 ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA binding; DNA recombination; DNA repair; DNA replication; SOS response; intracellular IPR011545; IPR004589; IPR006293; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR018982; IPR011991; ATP-dependent DNA helicase RecQ (EC 3.6.4.12) recQ HI_0728 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) TR40513_c0_g1_i4 Q4TVV3 DDX46_DANRE 0 GO:0005524; GO:0008026; GO:0015030; GO:0003723; GO:0008380; GO:0006397; GO:0016607 ATP binding; ATP-dependent helicase activity; Cajal body; RNA binding; RNA splicing; mRNA processing; nuclear speck IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) ddx46 Danio rerio (Zebrafish) (Brachydanio rerio) TR40513_c1_g2_i1 P80457 XDH_BOVIN 0 GO:0051537; GO:0008762; GO:0009055; GO:0005576; GO:0050660; GO:0005506; GO:0043546; GO:0005777; GO:0009115; GO:0004854; GO:0004855 "2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; electron carrier activity; extracellular region; flavin adenine dinucleotide binding; iron ion binding; molybdopterin cofactor binding; peroxisome; xanthine catabolic process; xanthine dehydrogenase activity; xanthine oxidase activity" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; IPR022407; IPR014307; Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] XDH Bos taurus (Bovine) TR40513_c1_g2_i2 Q8XD64 XDHD_ECO57 6.00E-14 GO:0051537; GO:0046872; GO:0016491; GO:0006144; GO:0006166 "2 iron, 2 sulfur cluster binding; metal ion binding; oxidoreductase activity; purine nucleobase metabolic process; purine ribonucleoside salvage" IPR002888; IPR000674; IPR008274; IPR017699; Probable hypoxanthine oxidase XdhD (EC 1.-.-.-) xdhD Z4220 ECs3754 Escherichia coli O157:H7 TR40513_c1_g2_i3 P80456 ADO_RABIT 0 GO:0051537; GO:0051287; GO:0008762; GO:0004031; GO:0005737; GO:0009055; GO:0050660; GO:0005506; GO:0043546 "2 iron, 2 sulfur cluster binding; NAD binding; UDP-N-acetylmuramate dehydrogenase activity; aldehyde oxidase activity; cytoplasm; electron carrier activity; flavin adenine dinucleotide binding; iron ion binding; molybdopterin cofactor binding" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR014313; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; IPR022407; Aldehyde oxidase (EC 1.2.3.1) (Retinal oxidase) AOX1 AO Oryctolagus cuniculus (Rabbit) TR40513_c1_g2_i4 Q0QLF1 NDMMS_EUBBA 2.00E-09 GO:0051187; GO:0046872; GO:0050138 cofactor catabolic process; metal ion binding; nicotinate dehydrogenase activity IPR008274; Cofactor degradation; nicotinate degradation; 6-hydroxynicotinate from nicotinate: step 1/1. Nicotinate dehydrogenase medium molybdopterin subunit (NDH) (EC 1.17.1.5) (Nicotinic acid hydroxylase medium molybdopterin subunit) (NAH) ndhM Eubacterium barkeri (Clostridium barkeri) TR40513_c1_g2_i6 Q8X6C5 XDHB_ECO57 2.00E-08 GO:0008762; GO:0050660; GO:0009114; GO:0006166; GO:0004854 UDP-N-acetylmuramate dehydrogenase activity; flavin adenine dinucleotide binding; hypoxanthine catabolic process; purine ribonucleoside salvage; xanthine dehydrogenase activity IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; Purine metabolism; hypoxanthine degradation; urate from hypoxanthine: step 1/2. Purine metabolism; hypoxanthine degradation; urate from hypoxanthine: step 2/2. Xanthine dehydrogenase FAD-binding subunit (EC 1.17.1.4) xdhB Z4206 ECs3740 Escherichia coli O157:H7 TR40513_c1_g2_i7 P80457 XDH_BOVIN 0 GO:0051537; GO:0008762; GO:0009055; GO:0005576; GO:0050660; GO:0005506; GO:0043546; GO:0005777; GO:0009115; GO:0004854; GO:0004855 "2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; electron carrier activity; extracellular region; flavin adenine dinucleotide binding; iron ion binding; molybdopterin cofactor binding; peroxisome; xanthine catabolic process; xanthine dehydrogenase activity; xanthine oxidase activity" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; IPR022407; IPR014307; Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] XDH Bos taurus (Bovine) TR40513_c1_g2_i8 Q9MYW6 XDH_FELCA 3.00E-165 GO:0051537; GO:0008762; GO:0009055; GO:0005576; GO:0050660; GO:0005506; GO:0043546; GO:0005777; GO:0009115; GO:0004854; GO:0004855 "2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; electron carrier activity; extracellular region; flavin adenine dinucleotide binding; iron ion binding; molybdopterin cofactor binding; peroxisome; xanthine catabolic process; xanthine dehydrogenase activity; xanthine oxidase activity" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; IPR022407; IPR014307; Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] XDH Felis catus (Cat) (Felis silvestris catus) TR40515_c2_g3_i4 Q52KN9 CWC22_XENLA 0 GO:0003723; GO:0008380; GO:0006397; GO:0016607; GO:0005681 RNA binding; RNA splicing; mRNA processing; nuclear speck; spliceosomal complex IPR016024; IPR003891; IPR016021; IPR003890; Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) cwc22 Xenopus laevis (African clawed frog) TR40516_c0_g1_i1 P55213 CASP3_RAT 4.00E-09 GO:0071407; GO:0004197; GO:0008234; GO:0005829; GO:0034349; GO:0021766; GO:0035556; GO:0007611; GO:0030182; GO:0016005; GO:0043525; GO:0006508; GO:0010165; GO:0043200; GO:0046677; GO:0032025; GO:0042493; GO:0032355; GO:0051384; GO:0009749; GO:0042542; GO:0001666; GO:0032496; GO:0035094; GO:0042060 cellular response to organic cyclic compound; cysteine-type endopeptidase activity; cysteine-type peptidase activity; cytosol; glial cell apoptotic process; hippocampus development; intracellular signal transduction; learning or memory; neuron differentiation; phospholipase A2 activator activity; positive regulation of neuron apoptotic process; proteolysis; response to X-ray; response to amino acid stimulus; response to antibiotic; response to cobalt ion; response to drug; response to estradiol stimulus; response to glucocorticoid stimulus; response to glucose stimulus; response to hydrogen peroxide; response to hypoxia; response to lipopolysaccharide; response to nicotine; wound healing IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (IRP) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] Casp3 Cpp32 Rattus norvegicus (Rat) TR40516_c0_g1_i3 Q08DY9 CASP3_BOVIN 1.00E-07 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Bos taurus (Bovine) TR40517_c0_g1_i1 Q6TEM9 MYLIA_DANRE 7.00E-16 GO:0005737; GO:0005856; GO:0005829; GO:0007369; GO:0016874; GO:0030178; GO:0016567; GO:0008270 cytoplasm; cytoskeleton; cytosol; gastrulation; ligase activity; negative regulation of Wnt receptor signaling pathway; protein ubiquitination; zinc ion binding IPR019749; IPR019750; IPR014352; IPR019748; IPR000299; IPR018979; IPR011993; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MYLIP-A (EC 6.3.2.-) (Myosin regulatory light chain-interacting protein A) (MIR-A) mylipa mir mylip si:ch211-266j17.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR40517_c0_g2_i2 Q6TEM9 MYLIA_DANRE 1.00E-67 GO:0005737; GO:0005856; GO:0005829; GO:0007369; GO:0016874; GO:0030178; GO:0016567; GO:0008270 cytoplasm; cytoskeleton; cytosol; gastrulation; ligase activity; negative regulation of Wnt receptor signaling pathway; protein ubiquitination; zinc ion binding IPR019749; IPR019750; IPR014352; IPR019748; IPR000299; IPR018979; IPR011993; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MYLIP-A (EC 6.3.2.-) (Myosin regulatory light chain-interacting protein A) (MIR-A) mylipa mir mylip si:ch211-266j17.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR40517_c0_g2_i3 O57457 E41L4_DANRE 1.00E-07 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR019749; IPR019750; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; Band 4.1-like protein 4 (Protein Nbl4) epb4.1l4 epb41l4 nbl4 Danio rerio (Zebrafish) (Brachydanio rerio) TR40517_c0_g2_i4 D3ZDI6 MYLIP_RAT 1.00E-69 GO:0006928; GO:0042632; GO:0005737; GO:0005856; GO:0019898; GO:0010989; GO:0007399; GO:0005886; GO:0045732; GO:0031648; GO:0042787; GO:0032803; GO:0004842; GO:0008270 cellular component movement; cholesterol homeostasis; cytoplasm; cytoskeleton; extrinsic to membrane; negative regulation of low-density lipoprotein particle clearance; nervous system development; plasma membrane; positive regulation of protein catabolic process; protein destabilization; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of low-density lipoprotein particle receptor catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR019749; IPR019750; IPR000798; IPR014352; IPR019748; IPR000299; IPR018979; IPR011993; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MYLIP (EC 6.3.2.-) (Inducible degrader of the LDL-receptor) (Idol) (Myosin regulatory light chain interacting protein) (MIR) Mylip Rattus norvegicus (Rat) TR40517_c0_g2_i5 P98170 XIAP_HUMAN 1.00E-09 GO:0016055; GO:0055070; GO:0043027; GO:0005829; GO:0097193; GO:0043066; GO:0005634; GO:0090263; GO:0030510; GO:0042127; GO:0050727; GO:0045088; GO:0070424; GO:0006974; GO:0004842; GO:0008270 P55210; P55211; Q9NR28; O43464; Q9JIY5; P46531; P63000; P57078; O43236-6; Q8IUQ4; P0CG48; P51668; P62837; P61077; P61088; Q13404 Wnt receptor signaling pathway; copper ion homeostasis; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytosol; intrinsic apoptotic signaling pathway; negative regulation of apoptotic process; nucleus; positive regulation of canonical Wnt receptor signaling pathway; regulation of BMP signaling pathway; regulation of cell proliferation; regulation of inflammatory response; regulation of innate immune response; regulation of nucleotide-binding oligomerization domain containing signaling pathway; response to DNA damage stimulus; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) XIAP API3 BIRC4 IAP3 Homo sapiens (Human) TR40518_c0_g1_i1 Q5U458 DJC11_MOUSE 1.00E-32 GO:0005743 mitochondrial inner membrane IPR024586; IPR001623; IPR018253; DnaJ homolog subfamily C member 11 Dnajc11 Mus musculus (Mouse) TR40518_c0_g1_i2 Q54PV9 DJC11_DICDI 3.00E-18 IPR024586; IPR001623; DnaJ homolog subfamily C member 11 homolog dnajc11 DDB_G0284263 Dictyostelium discoideum (Slime mold) TR40518_c0_g2_i2 Q5U458 DJC11_MOUSE 5.00E-90 GO:0005743 mitochondrial inner membrane IPR024586; IPR001623; IPR018253; DnaJ homolog subfamily C member 11 Dnajc11 Mus musculus (Mouse) TR40519_c1_g4_i1 Q9Z129 RECQ1_MOUSE 0 GO:0005524; GO:0043140; GO:0003677; GO:0006310; GO:0006281; GO:0006260; GO:0000733; GO:0015630; GO:0005634 ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA binding; DNA recombination; DNA repair; DNA replication; DNA strand renaturation; microtubule cytoskeleton; nucleus IPR011545; IPR004589; IPR014001; IPR001650; IPR027417; IPR018982; IPR011991; ATP-dependent DNA helicase Q1 (EC 3.6.4.12) (DNA-dependent ATPase Q1) (RecQ protein-like 1) Recql Recql1 Mus musculus (Mouse) TR40519_c1_g4_i2 Q9TXJ8 RECQ1_CAEEL 1.00E-179 GO:0005524; GO:0008026; GO:0006310; GO:0003676; GO:0005634 ATP binding; ATP-dependent helicase activity; DNA recombination; nucleic acid binding; nucleus IPR011545; IPR004589; IPR014001; IPR001650; IPR027417; IPR011991; Putative ATP-dependent DNA helicase Q1 (EC 3.6.4.12) K02F3.12 Caenorhabditis elegans TR40520_c3_g2_i1 O28476 Y1798_ARCFU 2.00E-30 GO:0005315; GO:0016021; GO:0006817; GO:0005886 inorganic phosphate transmembrane transporter activity; integral to membrane; phosphate ion transport; plasma membrane IPR001204; Putative phosphate permease AF_1798 AF_1798 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) TR40520_c3_g2_i2 Q6PFM1 S20AB_DANRE 1.00E-65 GO:0005315; GO:0016021; GO:0006817; GO:0015293 inorganic phosphate transmembrane transporter activity; integral to membrane; phosphate ion transport; symporter activity IPR001204; Sodium-dependent phosphate transporter 1-B (Solute carrier family 20 member 1-B) slc20a1b slc20a1 Danio rerio (Zebrafish) (Brachydanio rerio) TR40521_c0_g3_i1 O93336 HS2ST_XENLA 7.00E-140 GO:0000139; GO:0016021; GO:0008146 Golgi membrane; integral to membrane; sulfotransferase activity IPR007734; IPR027417; IPR005331; Heparan sulfate 2-O-sulfotransferase 1 (EC 2.8.2.-) hs2st1 hs2st Xenopus laevis (African clawed frog) TR40522_c1_g1_i1 Q15326 ZMY11_HUMAN 4.00E-88 GO:0003677; GO:0007049; GO:0008283; GO:0016568; GO:0005694; GO:0005737; GO:0019048; GO:0043124; GO:0046329; GO:2001237; GO:0000122; GO:0005634; GO:0006351; GO:0008270 P03255; P12978; P03230; P36941; Q13114 "DNA binding; cell cycle; cell proliferation; chromatin modification; chromosome; cytoplasm; modulation by virus of host morphology or physiology; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of JNK cascade; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; zinc ion binding" IPR001487; IPR000313; IPR019786; IPR011011; IPR002893; IPR001965; IPR019787; IPR001841; IPR013083; Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Protein BS69) ZMYND11 BS69 Homo sapiens (Human) TR40523_c4_g4_i2 Q92832 NELL1_HUMAN 4.00E-75 GO:0005509; GO:0030154; GO:0005576; GO:2000599; GO:0033689; GO:0007399; GO:0005635; GO:0048471; GO:0030501; GO:0045669; GO:0010468 Q6UW56 calcium ion binding; cell differentiation; extracellular region; negative regulation of cyclin catabolic process; negative regulation of osteoblast proliferation; nervous system development; nuclear envelope; perinuclear region of cytoplasm; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; regulation of gene expression IPR026823; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR009030; IPR001791; IPR001007; Protein kinase C-binding protein NELL1 (NEL-like protein 1) (Nel-related protein 1) NELL1 NRP1 Homo sapiens (Human) TR40525_c1_g1_i1 Q5ZJJ1 ZC11A_CHICK 6.00E-28 GO:0046872 metal ion binding IPR000571; Zinc finger CCCH domain-containing protein 11A ZC3H11A RCJMB04_17l7 Gallus gallus (Chicken) TR40526_c0_g1_i1 Q4VC17 ATS18_MOUSE 2.00E-164 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAM-TS 18) (ADAM-TS18) (ADAMTS-18) (EC 3.4.24.-) Adamts18 Mus musculus (Mouse) TR40526_c0_g1_i2 Q9UKP5 ATS6_HUMAN 1.00E-106 GO:0004222; GO:0008237; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; metallopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAM-TS 6) (ADAM-TS6) (ADAMTS-6) (EC 3.4.24.-) ADAMTS6 Homo sapiens (Human) TR40526_c0_g1_i4 Q4VC17 ATS18_MOUSE 7.00E-165 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAM-TS 18) (ADAM-TS18) (ADAMTS-18) (EC 3.4.24.-) Adamts18 Mus musculus (Mouse) TR40526_c0_g4_i1 Q8TE56 ATS17_HUMAN 5.00E-47 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; IPR007087; A disintegrin and metalloproteinase with thrombospondin motifs 17 (ADAM-TS 17) (ADAM-TS17) (ADAMTS-17) (EC 3.4.24.-) ADAMTS17 Homo sapiens (Human) TR40526_c0_g5_i1 O15072 ATS3_HUMAN 4.00E-09 GO:0030574; GO:0030199; GO:0008201; GO:0004222; GO:0016485; GO:0005578; GO:0006508; GO:0008270 collagen catabolic process; collagen fibril organization; heparin binding; metalloendopeptidase activity; protein processing; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAM-TS 3) (ADAM-TS3) (ADAMTS-3) (EC 3.4.24.-) (Procollagen II N-proteinase) (PC II-NP) (Procollagen II amino propeptide-processing enzyme) ADAMTS3 KIAA0366 Homo sapiens (Human) TR40527_c0_g1_i1 Q75B89 FES1_ASHGO 3.00E-11 GO:0000774; GO:0002181; GO:0022626; GO:0006417 adenyl-nucleotide exchange factor activity; cytoplasmic translation; cytosolic ribosome; regulation of translation IPR011989; IPR016024; IPR000225; IPR013918; Hsp70 nucleotide exchange factor FES1 FES1 ADL319W Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR40527_c0_g1_i2 Q99P31 HPBP1_MOUSE 2.00E-53 GO:0032436; GO:0031398 positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination IPR011989; IPR016024; Hsp70-binding protein 1 (HspBP1) (Heat shock protein-binding protein 1) (Hsp70-interacting protein 1) Hspbp1 Hspbp Mus musculus (Mouse) TR40527_c0_g1_i3 Q6BLA1 FES1_DEBHA 2.00E-09 GO:0005737; GO:0006417 cytoplasm; regulation of translation IPR011989; IPR016024; IPR013918; Hsp70 nucleotide exchange factor FES1 FES1 DEHA2F15180g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR40528_c0_g1_i2 P05091 ALDH2_HUMAN 0 GO:0004029; GO:0004030; GO:0005975; GO:0009055; GO:0006068; GO:0006069; GO:0005759; GO:0042136; GO:0006805 aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; carbohydrate metabolic process; electron carrier activity; ethanol catabolic process; ethanol oxidation; mitochondrial matrix; neurotransmitter biosynthetic process; xenobiotic metabolic process IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. "Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI)" ALDH2 ALDM Homo sapiens (Human) TR40530_c0_g1_i5 Q5VV17 OTUD1_HUMAN 2.00E-08 GO:0070536; GO:0006508; GO:0004843 protein K63-linked deubiquitination; proteolysis; ubiquitin-specific protease activity IPR003323; OTU domain-containing protein 1 (EC 3.4.19.12) (DUBA-7) OTUD1 DUBA7 OTDC1 Homo sapiens (Human) TR40531_c1_g2_i1 O01382 ICE_DROME 2.00E-06 GO:0004197; GO:0010623; GO:0016322; GO:0045476; GO:0046672; GO:0006508; GO:0010165; GO:0035070; GO:0048515; GO:0035103 Q9XYF4 cysteine-type endopeptidase activity; developmental programmed cell death; neuron remodeling; nurse cell apoptotic process; positive regulation of compound eye retinal cell programmed cell death; proteolysis; response to X-ray; salivary gland histolysis; spermatid differentiation; sterol regulatory element binding protein cleavage IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase (EC 3.4.22.-) (drICE) [Cleaved into: Caspase subunit p21; Caspase subunit p12] Ice CG7788 Drosophila melanogaster (Fruit fly) TR40531_c1_g2_i5 P55866 CASP3_XENLA 1.00E-08 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (xCPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] casp3 Xenopus laevis (African clawed frog) TR40531_c1_g2_i6 P70677 CASP3_MOUSE 2.00E-06 GO:0001782; GO:0043029; GO:0006309; GO:0004190; GO:0045165; GO:0071310; GO:0004861; GO:0097200; GO:0005829; GO:0097192; GO:0008625; GO:0034349; GO:0007507; GO:0008631; GO:0030216; GO:0030889; GO:0046007; GO:0043066; GO:0045736; GO:0051402; GO:0030264; GO:0043525; GO:0016485; GO:0006508; GO:0001836; GO:0006974; GO:0009411; GO:0009611; GO:0007605 P42859; P11103; P62270; Q96EK4 B cell homeostasis; T cell homeostasis; apoptotic DNA fragmentation; aspartic-type endopeptidase activity; cell fate commitment; cellular response to organic substance; cyclin-dependent protein serine/threonine kinase inhibitor activity; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cytosol; extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; glial cell apoptotic process; heart development; intrinsic apoptotic signaling pathway in response to oxidative stress; keratinocyte differentiation; negative regulation of B cell proliferation; negative regulation of activated T cell proliferation; negative regulation of apoptotic process; negative regulation of cyclin-dependent protein serine/threonine kinase activity; neuron apoptotic process; nuclear fragmentation involved in apoptotic nuclear change; positive regulation of neuron apoptotic process; protein processing; proteolysis; release of cytochrome c from mitochondria; response to DNA damage stimulus; response to UV; response to wounding; sensory perception of sound IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] Casp3 Cpp32 Mus musculus (Mouse) TR40531_c1_g2_i7 P89116 CASP1_SPOFR 2.00E-07 GO:0006915; GO:0004197; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-1 (EC 3.4.22.-) [Cleaved into: Caspase-1 subunit p19/18; Caspase-1 subunit p12] Spodoptera frugiperda (Fall armyworm) TR40534_c1_g2_i2 P26323 FLI1_MOUSE 5.00E-41 GO:0000980; GO:0008015; GO:0003682; GO:0035855; GO:0005634; GO:0009887; GO:0006355; GO:0003700; GO:0006351 "RNA polymerase II distal enhancer sequence-specific DNA binding; blood circulation; chromatin binding; megakaryocyte development; nucleus; organ morphogenesis; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; Friend leukemia integration 1 transcription factor (Retroviral integration site protein Fli-1) Fli1 Fli-1 Mus musculus (Mouse) TR40536_c7_g2_i1 Q803E1 CQ085_DANRE 3.00E-17 GO:0000166 nucleotide binding IPR019416; IPR012677; Uncharacterized protein C17orf85 homolog zgc:55870 Danio rerio (Zebrafish) (Brachydanio rerio) TR40536_c7_g2_i7 Q803E1 CQ085_DANRE 2.00E-18 GO:0000166 nucleotide binding IPR019416; IPR012677; Uncharacterized protein C17orf85 homolog zgc:55870 Danio rerio (Zebrafish) (Brachydanio rerio) TR4054_c0_g1_i1 Q0VAW7 ZF112_MOUSE 2.00E-16 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 112 (Zfp-112) Znf112 Zfp112 Mus musculus (Mouse) TR40540_c2_g1_i1 Q08548 ALE1_YEAST 3.00E-12 GO:0003841; GO:0047184; GO:0005783; GO:0005789; GO:0046474; GO:0016021 1-acylglycerol-3-phosphate O-acyltransferase activity; 1-acylglycerophosphocholine O-acyltransferase activity; endoplasmic reticulum; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process; integral to membrane IPR004299; Lysophospholipid acyltransferase (LPLAT) (EC 2.3.1.23) (EC 2.3.1.51) (1-acyl-sn-glycerol-3-phosphate acyltransferase) (AGPAT) (Lysophosphatidic acid acyltransferase) (LPAAT) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lysophosphatidylethanolamine acyltransferase) (LPEAT) ALE1 LCA1 LPT1 SLC4 YOR175C O3635 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40540_c2_g2_i1 Q5U4T9 MBOA7_XENLA 2.00E-67 GO:0016021; GO:0008654; GO:0016746 "integral to membrane; phospholipid biosynthetic process; transferase activity, transferring acyl groups" IPR004299; Lipid metabolism; phospholipid metabolism. Lysophospholipid acyltransferase 7 (LPLAT 7) (EC 2.3.1.-) (Leukocyte receptor cluster member 4) (Membrane-bound O-acyltransferase domain-containing protein 7) (O-acyltransferase domain-containing protein 7) mboat7 leng4 oact7 Xenopus laevis (African clawed frog) TR40540_c2_g2_i2 Q96N66 MBOA7_HUMAN 3.00E-51 GO:0005789; GO:0046474; GO:0016021; GO:0036149; GO:0044281; GO:0016747; GO:0021591 Q86WV6; Q8VCW4 "endoplasmic reticulum membrane; glycerophospholipid biosynthetic process; integral to membrane; phosphatidylinositol acyl-chain remodeling; small molecule metabolic process; transferase activity, transferring acyl groups other than amino-acyl groups; ventricular system development" IPR004299; Lipid metabolism; phospholipid metabolism. Lysophospholipid acyltransferase 7 (LPLAT 7) (EC 2.3.1.-) (1-acylglycerophosphatidylinositol O-acyltransferase) (EC 2.3.1.n4) (Bladder and breast carcinoma-overexpressed gene 1 protein) (Leukocyte receptor cluster member 4) (Lysophosphatidylinositol acyltransferase) (LPIAT) (Lyso-PI acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 7) (O-acyltransferase domain-containing protein 7) (h-mboa-7) MBOAT7 BB1 LENG4 OACT7 Homo sapiens (Human) TR40542_c1_g1_i1 P09405 NUCL_MOUSE 3.00E-31 GO:0003723; GO:0001525; GO:0005938; GO:0005730; GO:0005654; GO:0000166; GO:0030529; GO:0042162 Q9DC51 RNA binding; angiogenesis; cell cortex; nucleolus; nucleoplasm; nucleotide binding; ribonucleoprotein complex; telomeric DNA binding IPR012677; IPR000504; Nucleolin (Protein C23) Ncl Nuc Mus musculus (Mouse) TR40542_c1_g1_i2 P20397 NUCL_XENLA 3.00E-37 GO:0003677; GO:0003723; GO:0005730; GO:0000166 DNA binding; RNA binding; nucleolus; nucleotide binding IPR012677; IPR000504; Nucleolin (Protein C23) ncl Xenopus laevis (African clawed frog) TR40542_c1_g1_i6 P20397 NUCL_XENLA 7.00E-37 GO:0003677; GO:0003723; GO:0005730; GO:0000166 DNA binding; RNA binding; nucleolus; nucleotide binding IPR012677; IPR000504; Nucleolin (Protein C23) ncl Xenopus laevis (African clawed frog) TR40543_c1_g1_i1 O60285 NUAK1_HUMAN 3.00E-116 GO:0005524; GO:0007155; GO:0005737; GO:0046872; GO:0005634; GO:0004674; GO:0030155; GO:0042127; GO:2000772; GO:0035507; GO:0006974 O95835; P04637 ATP binding; cell adhesion; cytoplasm; metal ion binding; nucleus; protein serine/threonine kinase activity; regulation of cell adhesion; regulation of cell proliferation; regulation of cellular senescence; regulation of myosin-light-chain-phosphatase activity; response to DNA damage stimulus IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) NUAK1 ARK5 KIAA0537 OMPHK1 Homo sapiens (Human) TR40543_c1_g1_i4 O60285 NUAK1_HUMAN 3.00E-116 GO:0005524; GO:0007155; GO:0005737; GO:0046872; GO:0005634; GO:0004674; GO:0030155; GO:0042127; GO:2000772; GO:0035507; GO:0006974 O95835; P04637 ATP binding; cell adhesion; cytoplasm; metal ion binding; nucleus; protein serine/threonine kinase activity; regulation of cell adhesion; regulation of cell proliferation; regulation of cellular senescence; regulation of myosin-light-chain-phosphatase activity; response to DNA damage stimulus IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) NUAK1 ARK5 KIAA0537 OMPHK1 Homo sapiens (Human) TR40545_c0_g1_i1 P37727 RAE1_RAT 3.00E-115 GO:0005096; GO:0017137; GO:0004663; GO:0005968; GO:0006886; GO:0043547 P09527 GTPase activator activity; Rab GTPase binding; Rab geranylgeranyltransferase activity; Rab-protein geranylgeranyltransferase complex; intracellular protein transport; positive regulation of GTPase activity IPR018203; IPR001738; IPR016664; Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein homolog) (Rab escort protein 1) (REP-1) Chm Rep1 Rattus norvegicus (Rat) TR40545_c0_g1_i2 P50399 GDIB_RAT 8.00E-30 GO:0005096; GO:0005093; GO:0005829; GO:0016020; GO:0043547; GO:0015031; GO:0031267; GO:0016192 GTPase activator activity; Rab GDP-dissociation inhibitor activity; cytosol; membrane; positive regulation of GTPase activity; protein transport; small GTPase binding; vesicle-mediated transport IPR018203; IPR000806; Rab GDP dissociation inhibitor beta (Rab GDI beta) (GDI-3) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) Gdi2 Gdi3 Rattus norvegicus (Rat) TR40545_c0_g2_i1 P32864 RAEP_YEAST 2.00E-08 GO:0006888; GO:0005096; GO:0017137; GO:0005968; GO:0032858; GO:0016020; GO:0018344; GO:0006612 P32432; P36018 ER to Golgi vesicle-mediated transport; GTPase activator activity; Rab GTPase binding; Rab-protein geranylgeranyltransferase complex; activation of Rab GTPase activity; membrane; protein geranylgeranylation; protein targeting to membrane IPR018203; IPR017230; IPR000632; Rab proteins geranylgeranyltransferase component A (Rab escort protein) (REP) MRS6 MSI4 YOR370C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40545_c0_g2_i2 P26374 RAE2_HUMAN 2.00E-22 GO:0005096; GO:0004663; GO:0005968; GO:0006886; GO:0043547; GO:0007601 GTPase activator activity; Rab geranylgeranyltransferase activity; Rab-protein geranylgeranyltransferase complex; intracellular protein transport; positive regulation of GTPase activity; visual perception IPR018203; IPR001738; IPR016664; Rab proteins geranylgeranyltransferase component A 2 (Choroideremia-like protein) (Rab escort protein 2) (REP-2) CHML REP2 Homo sapiens (Human) TR40546_c0_g1_i1 Q4QRJ7 EIF2A_DANRE 3.00E-137 GO:0006417; GO:0003743 regulation of translation; translation initiation factor activity IPR011387; IPR013979; IPR015943; Eukaryotic translation initiation factor 2A (eIF-2A) eif2a zgc:110460 Danio rerio (Zebrafish) (Brachydanio rerio) TR40546_c0_g1_i2 Q9VNX8 EIF2A_DROME 2.00E-75 GO:0006417; GO:0003743 regulation of translation; translation initiation factor activity IPR011387; IPR013979; IPR015943; Eukaryotic translation initiation factor 2A (eIF-2A) CG7414 Drosophila melanogaster (Fruit fly) TR40548_c5_g4_i1 Q5R541 GEM_PONAB 5.00E-12 GO:0005525; GO:0003924; GO:0005886; GO:0007264 GTP binding; GTPase activity; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR017358; IPR020849; GTP-binding protein GEM GEM Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40548_c5_g4_i3 O35929 REM1_MOUSE 1.00E-19 GO:0005525; GO:0003924; GO:0016020; GO:0007264 GTP binding; GTPase activity; membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR017358; IPR020849; GTP-binding protein REM 1 (Rad and Gem-like GTP-binding protein 1) Rem1 Rem Mus musculus (Mouse) TR40548_c5_g4_i6 Q55CB0 RASU_DICDI 4.00E-10 GO:0005525; GO:0003924; GO:0007265; GO:0005886 GTP binding; GTPase activity; Ras protein signal transduction; plasma membrane IPR027417; IPR005225; IPR001806; IPR020849; Ras-like protein rasU rasU DDB_G0270138 Dictyostelium discoideum (Slime mold) TR40549_c2_g3_i1 P47025 MDV1_YEAST 7.00E-08 GO:0000266; GO:0000002; GO:0005741; GO:0016559; GO:0090141; GO:0043130 mitochondrial fission; mitochondrial genome maintenance; mitochondrial outer membrane; peroxisome fission; positive regulation of mitochondrial fission; ubiquitin binding IPR020472; IPR021061; IPR015943; IPR001680; IPR019775; IPR017986; Mitochondrial division protein 1 (Mitochondria fission 2 protein) MDV1 FIS2 GAG3 NET2 YJL112W J0802 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40549_c2_g3_i4 P39706 SWD1_YEAST 4.00E-09 GO:0048188; GO:0006348; GO:0000781; GO:0051568; GO:0000723 P38123 "Set1C/COMPASS complex; chromatin silencing at telomere; chromosome, telomeric region; histone H3-K4 methylation; telomere maintenance" IPR015943; IPR001680; IPR019775; IPR017986; COMPASS component SWD1 (Complex proteins associated with SET1 protein SWD1) (Set1C component SWD1) SWD1 CPS50 SAF49 YAR003W FUN16 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40549_c2_g3_i5 Q8YV57 Y2124_NOSS1 9.00E-25 GO:0004197; GO:0006508 cysteine-type endopeptidase activity; proteolysis IPR020472; IPR027417; IPR011600; IPR015943; IPR001680; IPR019775; IPR017986; Uncharacterized WD repeat-containing protein all2124 all2124 Nostoc sp. (strain PCC 7120 / UTEX 2576) TR40549_c2_g3_i6 O75529 TAF5L_HUMAN 2.00E-16 GO:0030914; GO:0043966; GO:0003700; GO:0003713; GO:0033276; GO:0006366 STAGA complex; histone H3 acetylation; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription factor TFTC complex; transcription from RNA polymerase II promoter IPR020472; IPR007582; IPR015943; IPR001680; IPR019775; IPR017986; TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65-beta) TAF5L PAF65B Homo sapiens (Human) TR40549_c2_g3_i7 Q5ZJH5 WDR61_CHICK 7.00E-74 GO:0016593; GO:0055087; GO:0080182; GO:0045638; GO:0051571; GO:2001162; GO:0032968; GO:0045944; GO:0035327 Cdc73/Paf1 complex; Ski complex; histone H3-K4 trimethylation; negative regulation of myeloid cell differentiation; positive regulation of histone H3-K4 methylation; positive regulation of histone H3-K79 methylation; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; transcriptionally active chromatin IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 61 WDR61 RCJMB04_18b20 Gallus gallus (Chicken) TR40549_c2_g6_i1 Q6P5M2 WDR61_DANRE 2.00E-80 GO:0016593; GO:0055087; GO:0032968; GO:0045944; GO:0035327 Cdc73/Paf1 complex; Ski complex; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; transcriptionally active chromatin IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 61 wdr61 zgc:77675 Danio rerio (Zebrafish) (Brachydanio rerio) TR40550_c0_g1_i1 Q9VM75 HEAT1_DROME 2.00E-59 GO:0022008; GO:0005730; GO:0006364; GO:0030529 neurogenesis; nucleolus; rRNA processing; ribonucleoprotein complex IPR011989; IPR016024; IPR012954; IPR022125; HEAT repeat-containing protein 1 homolog l(2)k09022 CG10805 Drosophila melanogaster (Fruit fly) TR40550_c0_g1_i2 Q7SY48 HEAT1_DANRE 5.00E-116 GO:0000462; GO:0043066; GO:0005730; GO:0043487; GO:0030529 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); negative regulation of apoptotic process; nucleolus; regulation of RNA stability; ribonucleoprotein complex" IPR011989; IPR016024; IPR012954; IPR022125; HEAT repeat-containing protein 1 (Protein BAP28) heatr1 zgc:63510 Danio rerio (Zebrafish) (Brachydanio rerio) TR40551_c2_g2_i1 P56377 AP1S2_HUMAN 4.00E-87 GO:0030119; GO:0000139; GO:0019886; GO:0005905; GO:0030659; GO:0005829; GO:0006897; GO:0006886; GO:0005765; GO:0006892; GO:0008565; GO:0050690; GO:0032588; GO:0016032 AP-type membrane coat adaptor complex; Golgi membrane; antigen processing and presentation of exogenous peptide antigen via MHC class II; coated pit; cytoplasmic vesicle membrane; cytosol; endocytosis; intracellular protein transport; lysosomal membrane; post-Golgi vesicle-mediated transport; protein transporter activity; regulation of defense response to virus by virus; trans-Golgi network membrane; viral process IPR016635; IPR022775; IPR000804; IPR011012; AP-1 complex subunit sigma-2 (Adapter-related protein complex 1 subunit sigma-1B) (Adaptor protein complex AP-1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin) AP1S2 DC22 Homo sapiens (Human) TR40553_c1_g2_i1 Q5I2M7 TLR9_FELCA 3.00E-07 GO:0002755; GO:0032009; GO:0005783; GO:0005789; GO:0005768; GO:0006954; GO:0045087; GO:0016021; GO:0005764; GO:0050729; GO:0045356; GO:0045359; GO:0045078; GO:0050707; GO:0002237; GO:0035197; GO:0034162; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; early phagosome; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; inflammatory response; innate immune response; integral to membrane; lysosome; positive regulation of inflammatory response; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-gamma biosynthetic process; regulation of cytokine secretion; response to molecule of bacterial origin; siRNA binding; toll-like receptor 9 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR000157; IPR027181; Toll-like receptor 9 (CD antigen CD289) TLR9 Felis catus (Cat) (Felis silvestris catus) TR40553_c1_g2_i2 P08953 TOLL_DROME 8.00E-22 GO:0033565; GO:0008063; GO:0019732; GO:0007155; GO:0019955; GO:0050830; GO:0005769; GO:0009897; GO:0007507; GO:0035172; GO:0030097; GO:0045087; GO:0016021; GO:0006963; GO:0006967; GO:0045610; GO:0007416; GO:0016201; GO:0004888; GO:0007352 Itself; Q7K105 ESCRT-0 complex; Toll signaling pathway; antifungal humoral response; cell adhesion; cytokine binding; defense response to Gram-positive bacterium; early endosome; external side of plasma membrane; heart development; hemocyte proliferation; hemopoiesis; innate immune response; integral to membrane; positive regulation of antibacterial peptide biosynthetic process; positive regulation of antifungal peptide biosynthetic process; regulation of hemocyte differentiation; synapse assembly; synaptic target inhibition; transmembrane signaling receptor activity; zygotic specification of dorsal/ventral axis IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) TR40553_c1_g2_i3 P08953 TOLL_DROME 2.00E-22 GO:0033565; GO:0008063; GO:0019732; GO:0007155; GO:0019955; GO:0050830; GO:0005769; GO:0009897; GO:0007507; GO:0035172; GO:0030097; GO:0045087; GO:0016021; GO:0006963; GO:0006967; GO:0045610; GO:0007416; GO:0016201; GO:0004888; GO:0007352 Itself; Q7K105 ESCRT-0 complex; Toll signaling pathway; antifungal humoral response; cell adhesion; cytokine binding; defense response to Gram-positive bacterium; early endosome; external side of plasma membrane; heart development; hemocyte proliferation; hemopoiesis; innate immune response; integral to membrane; positive regulation of antibacterial peptide biosynthetic process; positive regulation of antifungal peptide biosynthetic process; regulation of hemocyte differentiation; synapse assembly; synaptic target inhibition; transmembrane signaling receptor activity; zygotic specification of dorsal/ventral axis IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) TR40553_c1_g2_i4 Q9TZM3 LRK1_CAEEL 2.00E-07 GO:0005524; GO:0005525; GO:0005794; GO:0048846; GO:0034613; GO:0046872; GO:0043025; GO:0004674; GO:0034976; GO:0006979; GO:0007264; GO:0048489 ATP binding; GTP binding; Golgi apparatus; axon extension involved in axon guidance; cellular protein localization; metal ion binding; neuronal cell body; protein serine/threonine kinase activity; response to endoplasmic reticulum stress; response to oxidative stress; small GTPase mediated signal transduction; synaptic vesicle transport IPR002110; IPR020683; IPR011009; IPR001611; IPR003591; IPR013684; IPR027417; IPR000719; IPR020859; IPR017986; "Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) (Leucine-rich repeats, ras-like domain, kinase protein 1) (PARK8-related kinase)" lrk-1 T27C10.6 Caenorhabditis elegans TR40553_c1_g2_i5 Q7Z2Q7 LRR70_HUMAN 7.00E-06 GO:0016021 integral to membrane IPR000483; IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing protein 70 (Synleurin) LRRC70 UNQ1891/PRO4337 Homo sapiens (Human) TR40554_c1_g1_i1 Q6P8Y1 CAPSL_MOUSE 5.00E-06 GO:0005509; GO:0005737 calcium ion binding; cytoplasm IPR011992; IPR018247; IPR002048; IPR001125; Calcyphosin-like protein Capsl Mus musculus (Mouse) TR40554_c2_g1_i1 Q4PNS1 GPD_CANTR 2.00E-99 GO:0051287; GO:0005975; GO:0046168; GO:0004367; GO:0009331 NAD binding; carbohydrate metabolic process; glycerol-3-phosphate catabolic process; glycerol-3-phosphate dehydrogenase [NAD+] activity; glycerol-3-phosphate dehydrogenase complex IPR008927; IPR013328; IPR006168; IPR006109; IPR017751; IPR011128; IPR016040; Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC 1.1.1.8) GPD Candida tropicalis (Yeast) TR40554_c2_g1_i2 Q27928 GPDA_DROPS 2.00E-168 GO:0051287; GO:0005975; GO:0046168; GO:0004367; GO:0009331; GO:0006650 NAD binding; carbohydrate metabolic process; glycerol-3-phosphate catabolic process; glycerol-3-phosphate dehydrogenase [NAD+] activity; glycerol-3-phosphate dehydrogenase complex; glycerophospholipid metabolic process IPR008927; IPR013328; IPR006168; IPR006109; IPR017751; IPR011128; IPR016040; Phospholipid metabolism; alpha-glycerophosphate cycle. "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD-C) (GPDH-C) (EC 1.1.1.8)" Gpdh Drosophila pseudoobscura pseudoobscura (Fruit fly) TR40554_c2_g1_i3 B9KD88 GPDA_CAMLR 9.00E-12 GO:0051287; GO:0005975; GO:0046167; GO:0046168; GO:0047952; GO:0004367; GO:0036439; GO:0009331; GO:0006650; GO:0008654 NAD binding; carbohydrate metabolic process; glycerol-3-phosphate biosynthetic process; glycerol-3-phosphate catabolic process; glycerol-3-phosphate dehydrogenase [NAD(P)+] activity; glycerol-3-phosphate dehydrogenase [NAD+] activity; glycerol-3-phosphate dehydrogenase [NADP+] activity; glycerol-3-phosphate dehydrogenase complex; glycerophospholipid metabolic process; phospholipid biosynthetic process IPR008927; IPR013328; IPR006168; IPR006109; IPR011128; IPR016040; Membrane lipid metabolism; glycerophospholipid metabolism. Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) gpsA Cla_1206 Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060) TR40555_c0_g3_i1 Q6ZN84 CCD81_HUMAN 6.00E-72 IPR026295; IPR028034; Coiled-coil domain-containing protein 81 CCDC81 Homo sapiens (Human) TR40556_c0_g1_i1 Q90ZK6 ACVR1_CHICK 4.00E-173 GO:0005524; GO:0030509; GO:0000082; GO:0048185; GO:0032924; GO:0002526; GO:0003289; GO:0060317; GO:0060923; GO:0016477; GO:0003143; GO:0061445; GO:0042118; GO:0005887; GO:0046872; GO:0003183; GO:0032926; GO:2001237; GO:0060389; GO:0018107; GO:0030513; GO:0010694; GO:0030501; GO:2000017; GO:0010718; GO:0045669; GO:0010862; GO:0045944; GO:0045893; GO:0005057; GO:0004702; GO:0023014; GO:0050431; GO:0005025 "ATP binding; BMP signaling pathway; G1/S transition of mitotic cell cycle; activin binding; activin receptor signaling pathway; acute inflammatory response; atrial septum primum morphogenesis; cardiac epithelial to mesenchymal transition; cardiac muscle cell fate commitment; cell migration; embryonic heart tube morphogenesis; endocardial cushion cell fate commitment; endothelial cell activation; integral to plasma membrane; metal ion binding; mitral valve morphogenesis; negative regulation of activin receptor signaling pathway; negative regulation of extrinsic apoptotic signaling pathway; pathway-restricted SMAD protein phosphorylation; peptidyl-threonine phosphorylation; positive regulation of BMP signaling pathway; positive regulation of alkaline phosphatase activity; positive regulation of bone mineralization; positive regulation of determination of dorsal identity; positive regulation of epithelial to mesenchymal transition; positive regulation of osteoblast differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; receptor signaling protein activity; receptor signaling protein serine/threonine kinase activity; signal transduction by phosphorylation; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I" IPR000472; IPR011009; IPR000719; IPR017441; IPR008271; IPR003605; IPR000333; Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (Type I TGF B receptor) ACVR1 Gallus gallus (Chicken) TR40556_c0_g1_i2 Q90ZK6 ACVR1_CHICK 3.00E-173 GO:0005524; GO:0030509; GO:0000082; GO:0048185; GO:0032924; GO:0002526; GO:0003289; GO:0060317; GO:0060923; GO:0016477; GO:0003143; GO:0061445; GO:0042118; GO:0005887; GO:0046872; GO:0003183; GO:0032926; GO:2001237; GO:0060389; GO:0018107; GO:0030513; GO:0010694; GO:0030501; GO:2000017; GO:0010718; GO:0045669; GO:0010862; GO:0045944; GO:0045893; GO:0005057; GO:0004702; GO:0023014; GO:0050431; GO:0005025 "ATP binding; BMP signaling pathway; G1/S transition of mitotic cell cycle; activin binding; activin receptor signaling pathway; acute inflammatory response; atrial septum primum morphogenesis; cardiac epithelial to mesenchymal transition; cardiac muscle cell fate commitment; cell migration; embryonic heart tube morphogenesis; endocardial cushion cell fate commitment; endothelial cell activation; integral to plasma membrane; metal ion binding; mitral valve morphogenesis; negative regulation of activin receptor signaling pathway; negative regulation of extrinsic apoptotic signaling pathway; pathway-restricted SMAD protein phosphorylation; peptidyl-threonine phosphorylation; positive regulation of BMP signaling pathway; positive regulation of alkaline phosphatase activity; positive regulation of bone mineralization; positive regulation of determination of dorsal identity; positive regulation of epithelial to mesenchymal transition; positive regulation of osteoblast differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; receptor signaling protein activity; receptor signaling protein serine/threonine kinase activity; signal transduction by phosphorylation; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I" IPR000472; IPR011009; IPR000719; IPR017441; IPR008271; IPR003605; IPR000333; Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (Type I TGF B receptor) ACVR1 Gallus gallus (Chicken) TR40558_c1_g1_i1 Q0IJ05 OSBL9_XENTR 0 GO:0006869; GO:0005543 lipid transport; phospholipid binding IPR000648; IPR018494; IPR011993; IPR001849; Oxysterol-binding protein-related protein 9 osbpl9 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40558_c1_g2_i1 P16258 OSBP1_RABIT 2.00E-13 GO:0000139; GO:0015485; GO:0006869; GO:0005543 Golgi membrane; cholesterol binding; lipid transport; phospholipid binding IPR000648; IPR018494; IPR011993; IPR001849; Oxysterol-binding protein 1 OSBP Oryctolagus cuniculus (Rabbit) TR40558_c1_g2_i2 Q9ERS4 PKHA3_MOUSE 4.00E-14 GO:0005545; GO:0005794; GO:0016020 1-phosphatidylinositol binding; Golgi apparatus; membrane IPR011993; IPR001849; Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1) Plekha3 Fapp1 Mus musculus (Mouse) TR40559_c5_g3_i1 Q6DFS0 TMX2_XENTR 7.00E-68 GO:0045454; GO:0016021 cell redox homeostasis; integral to membrane IPR012336; IPR013766; Thioredoxin-related transmembrane protein 2 (Thioredoxin domain-containing protein 14) tmx2 txndc14 TEgg063n24.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40560_c0_g1_i1 O43301 HS12A_HUMAN 8.00E-94 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR40560_c0_g1_i3 Q9CZJ2 HS12B_MOUSE 7.00E-92 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR40562_c1_g1_i1 Q8VIJ6 SFPQ_MOUSE 4.00E-87 GO:0003677; GO:0006281; GO:0003723; GO:0000380; GO:0005737; GO:0000122; GO:0016363; GO:0000166; GO:0042382; GO:0006351 "DNA binding; DNA repair; RNA binding; alternative mRNA splicing, via spliceosome; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; nuclear matrix; nucleotide binding; paraspeckles; transcription, DNA-dependent" IPR012975; IPR012677; IPR000504; "Splicing factor, proline- and glutamine-rich (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)" Sfpq Mus musculus (Mouse) TR40562_c1_g1_i2 Q9H361 PABP3_HUMAN 4.00E-10 GO:0005737; GO:0016071; GO:0000166; GO:0008143 cytoplasm; mRNA metabolic process; nucleotide binding; poly(A) RNA binding IPR012677; IPR006515; IPR002004; IPR000504; Polyadenylate-binding protein 3 (PABP-3) (Poly(A)-binding protein 3) (Testis-specific poly(A)-binding protein) PABPC3 PABP3 PABPL3 Homo sapiens (Human) TR40562_c1_g1_i3 P21187 PABP_DROME 9.00E-12 GO:0071013; GO:0009953; GO:0005811; GO:0003730; GO:0000398; GO:0007140; GO:0007112; GO:0005875; GO:1901215; GO:0000166; GO:0048599; GO:0008143; GO:0045727; GO:0071011; GO:0045314; GO:0007289; GO:0007268 Q8SY33; Q9UPQ9; Q9HCJ0 "catalytic step 2 spliceosome; dorsal/ventral pattern formation; lipid particle; mRNA 3'-UTR binding; mRNA splicing, via spliceosome; male meiosis; male meiosis cytokinesis; microtubule associated complex; negative regulation of neuron death; nucleotide binding; oocyte development; poly(A) RNA binding; positive regulation of translation; precatalytic spliceosome; regulation of compound eye photoreceptor development; spermatid nucleus differentiation; synaptic transmission" IPR012677; IPR006515; IPR002004; IPR000504; Polyadenylate-binding protein (PABP) (Poly(A)-binding protein) pAbp CG5119 Drosophila melanogaster (Fruit fly) TR40562_c1_g1_i4 Q1DXH0 PABP_COCIM 7.00E-10 GO:0003723; GO:0005737; GO:0006397; GO:0051028; GO:0000166; GO:0005634; GO:0006417 RNA binding; cytoplasm; mRNA processing; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR012677; IPR006515; IPR002004; IPR000504; "Polyadenylate-binding protein, cytoplasmic and nuclear (PABP) (Poly(A)-binding protein) (Polyadenylate tail-binding protein)" PAB1 CIMG_04993 Coccidioides immitis (strain RS) (Valley fever fungus) TR40562_c1_g1_i5 Q28FX0 ELAV3_XENTR 4.00E-08 GO:0003723; GO:0030154; GO:0007399; GO:0000166; GO:0030529 RNA binding; cell differentiation; nervous system development; nucleotide binding; ribonucleoprotein complex IPR006548; IPR002343; IPR012677; IPR000504; ELAV-like protein 3 (Protein ElrC) elavl3 elrC TGas116i13.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40562_c1_g1_i6 Q8VIJ6 SFPQ_MOUSE 2.00E-87 GO:0003677; GO:0006281; GO:0003723; GO:0000380; GO:0005737; GO:0000122; GO:0016363; GO:0000166; GO:0042382; GO:0006351 "DNA binding; DNA repair; RNA binding; alternative mRNA splicing, via spliceosome; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; nuclear matrix; nucleotide binding; paraspeckles; transcription, DNA-dependent" IPR012975; IPR012677; IPR000504; "Splicing factor, proline- and glutamine-rich (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)" Sfpq Mus musculus (Mouse) TR40562_c1_g1_i8 Q6BI95 PABP_DEBHA 2.00E-11 GO:0003723; GO:0005737; GO:0006397; GO:0051028; GO:0000166; GO:0005634; GO:0006417 RNA binding; cytoplasm; mRNA processing; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR012677; IPR006515; IPR002004; IPR000504; "Polyadenylate-binding protein, cytoplasmic and nuclear (PABP) (Poly(A)-binding protein) (Polyadenylate tail-binding protein)" PAB1 DEHA2G12474g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR40562_c1_g1_i9 Q8VIJ6 SFPQ_MOUSE 3.00E-87 GO:0003677; GO:0006281; GO:0003723; GO:0000380; GO:0005737; GO:0000122; GO:0016363; GO:0000166; GO:0042382; GO:0006351 "DNA binding; DNA repair; RNA binding; alternative mRNA splicing, via spliceosome; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; nuclear matrix; nucleotide binding; paraspeckles; transcription, DNA-dependent" IPR012975; IPR012677; IPR000504; "Splicing factor, proline- and glutamine-rich (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)" Sfpq Mus musculus (Mouse) TR40563_c1_g2_i1 Q6AW47 EST5A_CANFA 2.00E-11 GO:0004091; GO:0005576 carboxylesterase activity; extracellular region IPR002018; IPR019826; IPR019819; Carboxylesterase 5A (EC 3.1.1.1) (Carboxylesterase-like urinary excreted protein homolog) (Cauxin) CES5A CES7 Canis familiaris (Dog) (Canis lupus familiaris) TR40563_c3_g1_i1 Q9C0R2 RTF22_SCHPO 2.00E-37 TR40563_c4_g2_i1 P20875 POL_HV1JR 3.00E-07 GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0075713; GO:0004533; GO:0030430; GO:0042025; GO:0020002; GO:0039651; GO:0016020; GO:0090305; GO:0006508; GO:0004523; GO:0005198; GO:0039604; GO:0046718; GO:0019013; GO:0075732; GO:0046797; GO:0008270 DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; establishment of integrated proviral latency; exoribonuclease H activity; host cell cytoplasm; host cell nucleus; host cell plasma membrane; induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process; membrane; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; structural molecule activity; suppression by virus of host translation; viral entry into host cell; viral nucleocapsid; viral penetration into host nucleus; viral procapsid maturation; zinc ion binding IPR001969; IPR000721; IPR001037; IPR001584; IPR017856; IPR003308; IPR000071; IPR012344; IPR018061; IPR001995; IPR021109; IPR008916; IPR008919; IPR010999; IPR012337; IPR002156; IPR000477; IPR010659; IPR010661; IPR001878; Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide p2; Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN)] gag-pol Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1) TR40563_c4_g2_i4 P20875 POL_HV1JR 3.00E-07 GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0075713; GO:0004533; GO:0030430; GO:0042025; GO:0020002; GO:0039651; GO:0016020; GO:0090305; GO:0006508; GO:0004523; GO:0005198; GO:0039604; GO:0046718; GO:0019013; GO:0075732; GO:0046797; GO:0008270 DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; establishment of integrated proviral latency; exoribonuclease H activity; host cell cytoplasm; host cell nucleus; host cell plasma membrane; induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process; membrane; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; structural molecule activity; suppression by virus of host translation; viral entry into host cell; viral nucleocapsid; viral penetration into host nucleus; viral procapsid maturation; zinc ion binding IPR001969; IPR000721; IPR001037; IPR001584; IPR017856; IPR003308; IPR000071; IPR012344; IPR018061; IPR001995; IPR021109; IPR008916; IPR008919; IPR010999; IPR012337; IPR002156; IPR000477; IPR010659; IPR010661; IPR001878; Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide p2; Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN)] gag-pol Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1) TR40563_c4_g4_i1 P24524 GLRA3_RAT 2.00E-96 GO:0030054; GO:0034707; GO:0016934; GO:0016594; GO:0005887; GO:0045211; GO:0022824 cell junction; chloride channel complex; extracellular-glycine-gated chloride channel activity; glycine binding; integral to plasma membrane; postsynaptic membrane; transmitter-gated ion channel activity IPR006028; IPR008127; IPR008130; IPR006202; IPR006201; IPR006029; IPR018000; Glycine receptor subunit alpha-3 Glra3 Rattus norvegicus (Rat) TR40563_c4_g4_i2 O93430 GLRA1_DANRE 4.00E-100 GO:0030054; GO:0034707; GO:0016934; GO:0016594; GO:0005887; GO:0045211; GO:0022824 cell junction; chloride channel complex; extracellular-glycine-gated chloride channel activity; glycine binding; integral to plasma membrane; postsynaptic membrane; transmitter-gated ion channel activity IPR006028; IPR008127; IPR008128; IPR006202; IPR006201; IPR006029; IPR018000; Glycine receptor subunit alphaZ1 glra1 Danio rerio (Zebrafish) (Brachydanio rerio) TR40563_c4_g4_i4 Q07263 ACHA3_BOVIN 2.00E-08 GO:0015464; GO:0004889; GO:0005892; GO:0035095; GO:0030054; GO:0007399; GO:0045211; GO:0060084 acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; behavioral response to nicotine; cell junction; nervous system development; postsynaptic membrane; synaptic transmission involved in micturition IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 Bos taurus (Bovine) TR40563_c5_g1_i1 Q9D3G9 RHOH_MOUSE 5.00E-07 GO:0005525; GO:0030217; GO:0005737; GO:0001772; GO:0019210; GO:0045576; GO:0005739; GO:0043124; GO:0007264 GTP binding; T cell differentiation; cytoplasm; immunological synapse; kinase inhibitor activity; mast cell activation; mitochondrion; negative regulation of I-kappaB kinase/NF-kappaB cascade; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Rho-related GTP-binding protein RhoH Rhoh Arhh Mus musculus (Mouse) TR40563_c6_g1_i1 P04323 POL3_DROME 2.00E-12 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR40564_c2_g1_i1 Q5R416 CTNA2_PONAB 0 GO:0015629; GO:0005912; GO:0030424; GO:0007409; GO:0016323; GO:0048854; GO:0005913; GO:0016337; GO:0005737; GO:0048813; GO:0030027; GO:0060134; GO:0021942; GO:0051823; GO:0005198 actin cytoskeleton; adherens junction; axon; axonogenesis; basolateral plasma membrane; brain morphogenesis; cell-cell adherens junction; cell-cell adhesion; cytoplasm; dendrite morphogenesis; lamellipodium; prepulse inhibition; radial glia guided migration of Purkinje cell; regulation of synapse structural plasticity; structural molecule activity IPR001033; IPR006077; IPR000633; Catenin alpha-2 (Alpha N-catenin) CTNNA2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40567_c3_g1_i1 Q9DD78 TLR21_CHICK 3.00E-10 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0005886; GO:0050729; GO:0050707; GO:0002237; GO:0035681; GO:0034134; GO:0034142; GO:0034146; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; plasma membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 15 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR018247; IPR001611; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 type-1 TLR2-1 Gallus gallus (Chicken) TR40568_c0_g1_i2 Q8TAC1 RFESD_HUMAN 4.00E-14 GO:0051537; GO:0046872; GO:0016491 "2 iron, 2 sulfur cluster binding; metal ion binding; oxidoreductase activity" IPR017941; Rieske domain-containing protein RFESD Homo sapiens (Human) TR40568_c0_g2_i2 P43935 Y077_HAEIN 3.00E-22 IPR007402; IPR009078; IPR011197; Uncharacterized protein HI_0077 HI_0077 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) TR40569_c5_g1_i1 Q8TB22 SPT20_HUMAN 0 GO:0030154; GO:0005576; GO:0006013; GO:0004476; GO:0007275; GO:0007283 cell differentiation; extracellular region; mannose metabolic process; mannose-6-phosphate isomerase activity; multicellular organismal development; spermatogenesis IPR008928; IPR012341; IPR010819; IPR004879; IPR024705; IPR012336; Spermatogenesis-associated protein 20 (Sperm-specific protein 411) (Ssp411) SPATA20 Homo sapiens (Human) TR40569_c5_g1_i4 P37509 YYAO_BACSU 5.00E-18 IPR004879; IPR012336; Uncharacterized protein YyaO yyaO BSU40790 Bacillus subtilis (strain 168) TR40570_c2_g1_i1 Q9Z309 CIB2_MOUSE 9.00E-53 GO:0005509; GO:0055074; GO:0005927; GO:0031594; GO:0045494; GO:0001917; GO:0032403; GO:0042383 calcium ion binding; calcium ion homeostasis; muscle tendon junction; neuromuscular junction; photoreceptor cell maintenance; photoreceptor inner segment; protein complex binding; sarcolemma IPR011992; IPR018247; IPR002048; Calcium and integrin-binding family member 2 (Kinase-interacting protein 2) (KIP 2) Cib2 Kip2 Mus musculus (Mouse) TR40570_c2_g1_i3 P87072 CANB_NEUCR 7.00E-10 GO:0000754; GO:0005955; GO:0005509; GO:0006873; GO:0031505 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion; calcineurin complex; calcium ion binding; cellular ion homeostasis; fungal-type cell wall organization IPR011992; IPR018247; IPR002048; IPR001125; Calcineurin subunit B (Calcineurin regulatory subunit) (Protein phosphatase 2B regulatory subunit) cnb-1 can-b NCU03833 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR40570_c2_g1_i4 P0CM54 CANB_CRYNJ 1.00E-10 GO:0005509; GO:0009405 calcium ion binding; pathogenesis IPR011992; IPR018247; IPR002048; Calcineurin subunit B (Calcineurin regulatory subunit) (Protein phosphatase 2B regulatory subunit) CNB1 CND00260 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR40571_c1_g2_i2 Q15643 TRIPB_HUMAN 4.00E-62 GO:0005794; GO:0005856; GO:0016020; GO:0005634; GO:0000042; GO:0003713; GO:0006366; GO:0003281 Golgi apparatus; cytoskeleton; membrane; nucleus; protein targeting to Golgi; transcription coactivator activity; transcription from RNA polymerase II promoter; ventricular septum development IPR000237; Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) TRIP11 CEV14 Homo sapiens (Human) TR40571_c1_g2_i3 O61309 NOS_LYMST 1.00E-06 GO:0010181; GO:0050661; GO:0050660; GO:0020037; GO:0005506; GO:0006809; GO:0004517 FMN binding; NADP binding; flavin adenine dinucleotide binding; heme binding; iron ion binding; nitric oxide biosynthetic process; nitric-oxide synthase activity IPR003097; IPR017927; IPR001094; IPR008254; IPR001709; IPR023173; IPR004030; IPR012144; IPR001433; IPR017938; Nitric oxide synthase (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) NOS Lymnaea stagnalis (Great pond snail) TR40571_c1_g2_i4 Q15643 TRIPB_HUMAN 6.00E-14 GO:0005794; GO:0005856; GO:0016020; GO:0005634; GO:0000042; GO:0003713; GO:0006366; GO:0003281 Golgi apparatus; cytoskeleton; membrane; nucleus; protein targeting to Golgi; transcription coactivator activity; transcription from RNA polymerase II promoter; ventricular septum development IPR000237; Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) TRIP11 CEV14 Homo sapiens (Human) TR40572_c0_g2_i1 Q6P8D9 UBC12_XENTR 2.00E-111 GO:0005524; GO:0019788; GO:0045116; GO:0018169; GO:0004842 ATP binding; NEDD8 ligase activity; protein neddylation; ribosomal S6-glutamic acid ligase activity; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein neddylation. NEDD8-conjugating enzyme Ubc12 (EC 6.3.2.-) (NEDD8 carrier protein) (NEDD8 protein ligase) (Ubiquitin-conjugating enzyme E2 M) ube2m ubc12 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40574_c0_g1_i1 Q8WUF8 F172A_HUMAN 7.00E-88 GO:0005783; GO:0005576 endoplasmic reticulum; extracellular region IPR019154; Protein FAM172A FAM172A C5orf21 Homo sapiens (Human) TR40574_c0_g1_i3 Q8WUF8 F172A_HUMAN 1.00E-87 GO:0005783; GO:0005576 endoplasmic reticulum; extracellular region IPR019154; Protein FAM172A FAM172A C5orf21 Homo sapiens (Human) TR40574_c0_g1_i4 Q7T297 F172A_DANRE 3.00E-83 GO:0005576 extracellular region IPR019154; Protein FAM172A fam172a zgc:64188 Danio rerio (Zebrafish) (Brachydanio rerio) TR40576_c1_g2_i1 Q5ZKI4 CCD93_CHICK 0 IPR019159; Coiled-coil domain-containing protein 93 CCDC93 RCJMB04_10i21 Gallus gallus (Chicken) TR40577_c0_g1_i1 Q5T5U3 RHG21_HUMAN 4.00E-29 GO:0005096; GO:0005794; GO:0000139; GO:0007030; GO:0030054; GO:0030659; GO:0005856; GO:0051683; GO:0051684; GO:0072384; GO:0005543; GO:0043547; GO:0007165 P84078; P29692 GTPase activator activity; Golgi apparatus; Golgi membrane; Golgi organization; cell junction; cytoplasmic vesicle membrane; cytoskeleton; establishment of Golgi localization; maintenance of Golgi location; organelle transport along microtubule; phospholipid binding; positive regulation of GTPase activity; signal transduction IPR001478; IPR011993; IPR001849; IPR008936; IPR000198; Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21) ARHGAP21 ARHGAP10 KIAA1424 Homo sapiens (Human) TR40577_c0_g1_i2 Q6AYC5 RHG15_RAT 1.00E-73 GO:0030675; GO:0005737; GO:0016020; GO:0005543; GO:0008360; GO:0007165 Rac GTPase activator activity; cytoplasm; membrane; phospholipid binding; regulation of cell shape; signal transduction IPR011993; IPR001849; IPR015767; IPR008936; IPR000198; Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) Arhgap15 Rattus norvegicus (Rat) TR40577_c0_g1_i4 Q811M1 RHG15_MOUSE 1.00E-70 GO:0030675; GO:0005737; GO:0016020; GO:0005543; GO:0008360; GO:0007165 Rac GTPase activator activity; cytoplasm; membrane; phospholipid binding; regulation of cell shape; signal transduction IPR011993; IPR001849; IPR015767; IPR008936; IPR000198; Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) Arhgap15 Mus musculus (Mouse) TR40577_c0_g2_i3 Q8IWW6 RHG12_HUMAN 1.00E-09 GO:0005096; GO:0005829; GO:0005543; GO:0043547; GO:0051056; GO:0007264 GTPase activator activity; cytosol; phospholipid binding; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR011993; IPR001849; IPR015767; IPR008936; IPR000198; IPR001452; IPR001202; Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12) ARHGAP12 Homo sapiens (Human) TR40578_c4_g3_i2 A5PN38 F151A_DANRE 9.00E-34 GO:0016021 integral to membrane IPR019356; Protein FAM151A fam151a si:ch211-215b16.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR40578_c4_g3_i3 Q6UXP7 F151B_HUMAN 2.00E-47 IPR019356; Protein FAM151B FAM151B UNQ9217/PRO28685 Homo sapiens (Human) TR40578_c4_g3_i4 Q6UXP7 F151B_HUMAN 4.00E-45 IPR019356; Protein FAM151B FAM151B UNQ9217/PRO28685 Homo sapiens (Human) TR4058_c0_g1_i1 Q9NZ32 ARP10_HUMAN 6.00E-55 GO:0005737; GO:0005869; GO:0007018 cytoplasm; dynactin complex; microtubule-based movement IPR004000; IPR027127; Actin-related protein 10 (Actin-related protein 11) (hARP11) ACTR10 ACTR11 ARP11 Homo sapiens (Human) TR40580_c2_g2_i1 Q54HW1 PSD10_DICDI 1.00E-13 IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) psmD10 DDB_G0289189 Dictyostelium discoideum (Slime mold) TR40580_c2_g2_i2 O15084 ANR28_HUMAN 2.00E-17 GO:0005654 Q14185; O00743; Q9UPN7; O75170; Q5H9R7; Q9H2K2 nucleoplasm IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) ANKRD28 KIAA0379 Homo sapiens (Human) TR40582_c0_g1_i1 P90893 YM9I_CAEEL 8.00E-48 GO:0006508; GO:0008236 proteolysis; serine-type peptidase activity IPR008758; Putative serine protease F56F10.1 (EC 3.4.-.-) F56F10.1 Caenorhabditis elegans TR40583_c0_g1_i3 Q95XM2 PHM_CAEEL 4.00E-76 GO:0005507; GO:0005576; GO:0016020; GO:0006518; GO:0004504 copper ion binding; extracellular region; membrane; peptide metabolic process; peptidylglycine monooxygenase activity IPR014784; IPR014783; IPR000323; IPR000720; IPR008977; Probable peptidylglycine alpha-hydroxylating monooxygenase Y71G12B.4 (PHM) (EC 1.14.17.3) Y71G12B.4 Caenorhabditis elegans TR40583_c0_g1_i4 P12890 AMDB_XENLA 2.00E-57 GO:0005507; GO:0016021; GO:0006518; GO:0004598; GO:0004504; GO:0030658 copper ion binding; integral to membrane; peptide metabolic process; peptidylamidoglycolate lyase activity; peptidylglycine monooxygenase activity; transport vesicle membrane IPR011042; IPR014784; IPR020611; IPR014783; IPR000323; IPR001258; IPR013017; IPR000720; IPR008977; Peptidyl-glycine alpha-amidating monooxygenase B (PAM-B) (Peptide C-terminal alpha-amidating enzyme II) (AE-II) (Peptidyl-glycine alpha-amidating monooxygenase II) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase B (PHM-B) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase B (EC 4.3.2.5) (Peptidylamidoglycolate lyase-B) (PAL-B)] pam-b Xenopus laevis (African clawed frog) TR40583_c0_g1_i5 Q95XM2 PHM_CAEEL 5.00E-87 GO:0005507; GO:0005576; GO:0016020; GO:0006518; GO:0004504 copper ion binding; extracellular region; membrane; peptide metabolic process; peptidylglycine monooxygenase activity IPR014784; IPR014783; IPR000323; IPR000720; IPR008977; Probable peptidylglycine alpha-hydroxylating monooxygenase Y71G12B.4 (PHM) (EC 1.14.17.3) Y71G12B.4 Caenorhabditis elegans TR40584_c3_g2_i1 Q9A7V7 PH4H_CAUCR 8.00E-27 GO:0006559; GO:0005506; GO:0004505 L-phenylalanine catabolic process; iron ion binding; phenylalanine 4-monooxygenase activity IPR001273; IPR018301; IPR019774; IPR005960; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6. Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase) phhA CC_1612 Caulobacter crescentus (strain ATCC 19089 / CB15) TR40584_c3_g2_i2 P17276 PH4H_DROME 4.00E-95 GO:0006559; GO:0005506; GO:0005811; GO:0007616; GO:0006909; GO:0004505; GO:0042427; GO:0004510 L-phenylalanine catabolic process; iron ion binding; lipid particle; long-term memory; phagocytosis; phenylalanine 4-monooxygenase activity; serotonin biosynthetic process; tryptophan 5-monooxygenase activity IPR001273; IPR018301; IPR019774; IPR005961; IPR019773; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6. Protein henna (EC 1.14.16.1) (EC 1.14.16.4) (Phe-4-monooxygenase) (Phenylalanine-4-hydroxylase) (PAH) (Tryptophan 5-hydroxylase) (TRH) (Tryptophan 5-monooxygenase) Hn pah Tph CG7399 Drosophila melanogaster (Fruit fly) TR40584_c3_g2_i3 P43334 PH4H_PSEAE 1.00E-27 GO:0009094; GO:0006559; GO:0005506; GO:0004505; GO:0016775; GO:0000162; GO:0006571 "L-phenylalanine biosynthetic process; L-phenylalanine catabolic process; iron ion binding; phenylalanine 4-monooxygenase activity; phosphotransferase activity, nitrogenous group as acceptor; tryptophan biosynthetic process; tyrosine biosynthetic process" IPR001273; IPR018301; IPR019774; IPR005960; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6. Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase) phhA PA0872 Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) TR40584_c3_g5_i1 P70080 TPH1_CHICK 3.00E-15 GO:0016597; GO:0009072; GO:0046849; GO:0005506; GO:0060749; GO:0042427; GO:0004510 amino acid binding; aromatic amino acid family metabolic process; bone remodeling; iron ion binding; mammary gland alveolus development; serotonin biosynthetic process; tryptophan 5-monooxygenase activity IPR002912; IPR001273; IPR018301; IPR019774; IPR005963; IPR019773; Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2. Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1) TPH1 TPH Gallus gallus (Chicken) TR40584_c3_g5_i2 P17276 PH4H_DROME 2.00E-19 GO:0006559; GO:0005506; GO:0005811; GO:0007616; GO:0006909; GO:0004505; GO:0042427; GO:0004510 L-phenylalanine catabolic process; iron ion binding; lipid particle; long-term memory; phagocytosis; phenylalanine 4-monooxygenase activity; serotonin biosynthetic process; tryptophan 5-monooxygenase activity IPR001273; IPR018301; IPR019774; IPR005961; IPR019773; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6. Protein henna (EC 1.14.16.1) (EC 1.14.16.4) (Phe-4-monooxygenase) (Phenylalanine-4-hydroxylase) (PAH) (Tryptophan 5-hydroxylase) (TRH) (Tryptophan 5-monooxygenase) Hn pah Tph CG7399 Drosophila melanogaster (Fruit fly) TR40587_c0_g1_i1 G5E8K5 ANK3_MOUSE 7.00E-10 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR40588_c1_g3_i2 O95429 BAG4_HUMAN 1.00E-14 GO:0071364; GO:0071356; GO:0005829; GO:0043066; GO:2001145; GO:0005634; GO:0005886; GO:0030838; GO:0045785; GO:0010763; GO:0033138; GO:0051897; GO:0051496; GO:0006457; GO:0072659; GO:0005057; GO:0097178 "cellular response to epidermal growth factor stimulus; cellular response to tumor necrosis factor; cytosol; negative regulation of apoptotic process; negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; nucleus; plasma membrane; positive regulation of actin filament polymerization; positive regulation of cell adhesion; positive regulation of fibroblast migration; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of stress fiber assembly; protein folding; protein localization to plasma membrane; receptor signaling protein activity; ruffle assembly" IPR003103; BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains) BAG4 SODD Homo sapiens (Human) TR40592_c0_g2_i2 P31597 EAA3_RABIT 4.00E-122 GO:0016021; GO:0017153 integral to membrane; sodium:dicarboxylate symporter activity IPR001991; IPR018107; Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1) SLC1A1 EAAC1 EAAT3 Oryctolagus cuniculus (Rabbit) TR40592_c0_g2_i3 O19105 AAAT_RABIT 2.00E-94 GO:0016021; GO:0042470; GO:0017153 integral to membrane; melanosome; sodium:dicarboxylate symporter activity IPR001991; IPR018107; Neutral amino acid transporter B(0) (ATB(0)) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5) SLC1A5 ASCT2 Oryctolagus cuniculus (Rabbit) TR40593_c0_g3_i1 Q6GPZ5 SPSAB_XENLA 6.00E-12 GO:0016021; GO:0017059; GO:0006665 integral to membrane; serine C-palmitoyltransferase complex; sphingolipid metabolic process IPR024512; Lipid metabolism; sphingolipid metabolism. Serine palmitoyltransferase small subunit A-B (Small subunit of serine palmitoyltransferase A-B) (ssSPTa-B) sptssa-b ssspta-b Xenopus laevis (African clawed frog) TR40594_c3_g2_i1 P15129 CP4B1_RAT 1.00E-107 GO:0070330; GO:0018879; GO:0008144; GO:0005789; GO:0042738; GO:0018917; GO:0018585; GO:0020037; GO:0043231; GO:0005506; GO:0004497 aromatase activity; biphenyl metabolic process; drug binding; endoplasmic reticulum membrane; exogenous drug catabolic process; fluorene metabolic process; fluorene oxygenase activity; heme binding; intracellular membrane-bounded organelle; iron ion binding; monooxygenase activity IPR001128; IPR017972; IPR002401; Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (Cytochrome P450 L-2) (Cytochrome P450 isozyme 5) Cyp4b1 Cyp4b-1 Rattus norvegicus (Rat) TR40595_c1_g1_i2 P34556 CDK1_CAEEL 6.00E-22 GO:0005524; GO:0008353; GO:0051301; GO:0004693; GO:0005737; GO:0007126; GO:0005815; GO:0007067; GO:0000087; GO:0005634; GO:0001556; GO:0045836; GO:0051446 ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; cell division; cyclin-dependent protein serine/threonine kinase activity; cytoplasm; meiosis; microtubule organizing center; mitosis; mitotic M phase; nucleus; oocyte maturation; positive regulation of meiosis; positive regulation of meiotic cell cycle IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) cdk-1 ncc-1 T05G5.3 Caenorhabditis elegans TR40595_c1_g1_i4 Q3UMM4 CDK10_MOUSE 1.00E-59 GO:0005524; GO:0004693 ATP binding; cyclin-dependent protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 10 (EC 2.7.11.22) (Cell division protein kinase 10) Cdk10 Mus musculus (Mouse) TR40595_c1_g1_i5 P51953 CDK7_CARAU 3.00E-65 GO:0005524; GO:0008353; GO:0051301; GO:0004693; GO:0007126; GO:0005634 ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; cell division; cyclin-dependent protein serine/threonine kinase activity; meiosis; nucleus IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; "Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (40 kDa protein kinase) (CDC2/CDK2,4-activating kinase) (Cell division protein kinase 7) (P40 MO15)" cdk7 mo15 Carassius auratus (Goldfish) TR40595_c1_g1_i6 P51958 CDK1_CARAU 7.00E-74 GO:0005524; GO:0008353; GO:0051301; GO:0004693; GO:0005737; GO:0005815; GO:0007067; GO:0005634 ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; cell division; cyclin-dependent protein serine/threonine kinase activity; cytoplasm; microtubule organizing center; mitosis; nucleus IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) cdk1 cdc2 Carassius auratus (Goldfish) TR40595_c1_g1_i7 Q3UMM4 CDK10_MOUSE 5.00E-171 GO:0005524; GO:0004693 ATP binding; cyclin-dependent protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 10 (EC 2.7.11.22) (Cell division protein kinase 10) Cdk10 Mus musculus (Mouse) TR40596_c1_g1_i1 G5E8K5 ANK3_MOUSE 1.00E-29 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR40596_c1_g1_i2 Q08DV6 ASB3_BOVIN 2.00E-15 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 3 (ASB-3) ASB3 Bos taurus (Bovine) TR40596_c1_g1_i3 Q9ULJ7 ANR50_HUMAN 3.00E-30 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) TR40596_c1_g3_i2 G5E8K5 ANK3_MOUSE 1.00E-06 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR40597_c0_g1_i1 Q9VLM8 SYAC_DROME 0 GO:0005524; GO:0004813; GO:0006419; GO:0005737; GO:0046872; GO:0000049 ATP binding; alanine-tRNA ligase activity; alanyl-tRNA aminoacylation; cytoplasm; metal ion binding; tRNA binding IPR002318; IPR018162; IPR018165; IPR018164; IPR023033; IPR003156; IPR018163; IPR009000; IPR012947; "Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)" Aats-ala alaS CG13391 Drosophila melanogaster (Fruit fly) TR40597_c0_g1_i2 P24075 SYA_RHILV 1.00E-49 GO:0005524; GO:0004813; GO:0006419; GO:0005737; GO:0000049 ATP binding; alanine-tRNA ligase activity; alanyl-tRNA aminoacylation; cytoplasm; tRNA binding IPR018165; IPR018164; Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Fragment) alaS Rhizobium leguminosarum bv. viciae TR40597_c0_g1_i3 Q9VLM8 SYAC_DROME 0 GO:0005524; GO:0004813; GO:0006419; GO:0005737; GO:0046872; GO:0000049 ATP binding; alanine-tRNA ligase activity; alanyl-tRNA aminoacylation; cytoplasm; metal ion binding; tRNA binding IPR002318; IPR018162; IPR018165; IPR018164; IPR023033; IPR003156; IPR018163; IPR009000; IPR012947; "Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)" Aats-ala alaS CG13391 Drosophila melanogaster (Fruit fly) TR40597_c0_g2_i1 A8MBI2 SYA_CALMQ 2.00E-22 GO:0005524; GO:0004813; GO:0006419; GO:0005737; GO:0046872; GO:0000049 ATP binding; alanine-tRNA ligase activity; alanyl-tRNA aminoacylation; cytoplasm; metal ion binding; tRNA binding IPR002318; IPR018162; IPR018165; IPR018164; IPR022429; IPR018163; IPR009000; IPR012947; Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) alaS Cmaq_1898 Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167) TR40597_c0_g2_i2 Q8BGQ7 SYAC_MOUSE 0 GO:0005524; GO:0004813; GO:0006419; GO:0016597; GO:0002161; GO:0021680; GO:0005737; GO:0030968; GO:0001942; GO:0046872; GO:0043524; GO:0050885; GO:0006457; GO:0043200; GO:0000049; GO:0006400 ATP binding; alanine-tRNA ligase activity; alanyl-tRNA aminoacylation; amino acid binding; aminoacyl-tRNA editing activity; cerebellar Purkinje cell layer development; cytoplasm; endoplasmic reticulum unfolded protein response; hair follicle development; metal ion binding; negative regulation of neuron apoptotic process; neuromuscular process controlling balance; protein folding; response to amino acid stimulus; tRNA binding; tRNA modification IPR002318; IPR018162; IPR018165; IPR018164; IPR023033; IPR003156; IPR018163; IPR009000; IPR012947; "Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)" Aars Mus musculus (Mouse) TR40597_c0_g2_i3 P21894 SYAC_BOMMO 0 GO:0005524; GO:0004813; GO:0006419; GO:0005737; GO:0046872; GO:0000049 ATP binding; alanine-tRNA ligase activity; alanyl-tRNA aminoacylation; cytoplasm; metal ion binding; tRNA binding IPR002318; IPR018162; IPR018165; IPR018164; IPR023033; IPR003156; IPR018163; IPR009000; IPR012947; "Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)" Bombyx mori (Silk moth) TR40597_c0_g2_i4 Q8BGQ7 SYAC_MOUSE 0 GO:0005524; GO:0004813; GO:0006419; GO:0016597; GO:0002161; GO:0021680; GO:0005737; GO:0030968; GO:0001942; GO:0046872; GO:0043524; GO:0050885; GO:0006457; GO:0043200; GO:0000049; GO:0006400 ATP binding; alanine-tRNA ligase activity; alanyl-tRNA aminoacylation; amino acid binding; aminoacyl-tRNA editing activity; cerebellar Purkinje cell layer development; cytoplasm; endoplasmic reticulum unfolded protein response; hair follicle development; metal ion binding; negative regulation of neuron apoptotic process; neuromuscular process controlling balance; protein folding; response to amino acid stimulus; tRNA binding; tRNA modification IPR002318; IPR018162; IPR018165; IPR018164; IPR023033; IPR003156; IPR018163; IPR009000; IPR012947; "Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)" Aars Mus musculus (Mouse) TR40597_c0_g2_i6 O57848 ALAXM_PYRHO 1.00E-08 GO:0005524; GO:0004813; GO:0006419; GO:0002161; GO:0005737; GO:0046872; GO:0003676 ATP binding; alanine-tRNA ligase activity; alanyl-tRNA aminoacylation; aminoacyl-tRNA editing activity; cytoplasm; metal ion binding; nucleic acid binding IPR018165; IPR018164; IPR018163; IPR009000; IPR012947; Alanyl-tRNA editing protein AlaX-M (AlaX-M) (Alanyl-tRNA deacylase AlaX-M) alaXM PH0108 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) TR40597_c0_g2_i7 Q8BGQ7 SYAC_MOUSE 0 GO:0005524; GO:0004813; GO:0006419; GO:0016597; GO:0002161; GO:0021680; GO:0005737; GO:0030968; GO:0001942; GO:0046872; GO:0043524; GO:0050885; GO:0006457; GO:0043200; GO:0000049; GO:0006400 ATP binding; alanine-tRNA ligase activity; alanyl-tRNA aminoacylation; amino acid binding; aminoacyl-tRNA editing activity; cerebellar Purkinje cell layer development; cytoplasm; endoplasmic reticulum unfolded protein response; hair follicle development; metal ion binding; negative regulation of neuron apoptotic process; neuromuscular process controlling balance; protein folding; response to amino acid stimulus; tRNA binding; tRNA modification IPR002318; IPR018162; IPR018165; IPR018164; IPR023033; IPR003156; IPR018163; IPR009000; IPR012947; "Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)" Aars Mus musculus (Mouse) TR40599_c2_g1_i1 Q8R420 ABCA3_MOUSE 2.00E-144 GO:0005524; GO:0006200; GO:0016887; GO:0097233; GO:0016021; GO:0005886; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; alveolar lamellar body membrane; integral to membrane; plasma membrane; transport IPR003593; IPR026082; IPR003439; IPR017871; IPR026969; IPR027417; ATP-binding cassette sub-family A member 3 Abca3 Mus musculus (Mouse) TR40599_c3_g1_i1 Q7UP21 PSTB_RHOBA 3.00E-06 GO:0005524; GO:0006200; GO:0005315; GO:0015415; GO:0005886 ATP binding; ATP catabolic process; inorganic phosphate transmembrane transporter activity; phosphate ion transmembrane-transporting ATPase activity; plasma membrane IPR003593; IPR003439; IPR017871; IPR015850; IPR027417; IPR005670; Phosphate import ATP-binding protein PstB (EC 3.6.3.27) (ABC phosphate transporter) (Phosphate-transporting ATPase) pstB RB7211 Rhodopirellula baltica (strain SH1) TR40599_c3_g3_i1 Q7TNJ2 ABCA7_RAT 1.00E-94 GO:0005524; GO:0006200; GO:0016887; GO:0000139; GO:0010008; GO:0016021; GO:0006909; GO:0005886 ATP binding; ATP catabolic process; ATPase activity; Golgi membrane; endosome membrane; integral to membrane; phagocytosis; plasma membrane IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 7 Abca7 Rattus norvegicus (Rat) TR40599_c3_g3_i2 Q91V24 ABCA7_MOUSE 1.00E-94 GO:0005524; GO:0006200; GO:0016887; GO:0000139; GO:0016324; GO:0010008; GO:0016021; GO:0005622; GO:0006909; GO:0033700; GO:0005548 ATP binding; ATP catabolic process; ATPase activity; Golgi membrane; apical plasma membrane; endosome membrane; integral to membrane; intracellular; phagocytosis; phospholipid efflux; phospholipid transporter activity IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 7 Abca7 Mus musculus (Mouse) TR40599_c3_g3_i3 P41234 ABCA2_MOUSE 3.00E-95 GO:0005524; GO:0016887; GO:0042632; GO:0016023; GO:0005768; GO:0010008; GO:0016021; GO:0005765; GO:0005815; GO:0032383; GO:0006357; GO:0048545; GO:0006810 ATP binding; ATPase activity; cholesterol homeostasis; cytoplasmic membrane-bounded vesicle; endosome; endosome membrane; integral to membrane; lysosomal membrane; microtubule organizing center; regulation of intracellular cholesterol transport; regulation of transcription from RNA polymerase II promoter; response to steroid hormone stimulus; transport IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 2 (ATP-binding cassette transporter 2) (ATP-binding cassette 2) Abca2 Abc2 Mus musculus (Mouse) TR40601_c0_g1_i4 P29054 TF2B_XENLA 1.00E-157 GO:0006352; GO:0005634; GO:0006355; GO:0008270 "DNA-dependent transcription, initiation; nucleus; regulation of transcription, DNA-dependent; zinc ion binding" IPR013763; IPR000812; IPR023486; IPR013150; IPR013137; Transcription initiation factor IIB (General transcription factor TFIIB) gtf2b Xenopus laevis (African clawed frog) TR40603_c4_g1_i2 Q9BX70 BTBD2_HUMAN 1.00E-22 GO:0000932 Q7L5N1; P04637 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) TR40603_c4_g1_i3 Q6P8B3 SPOP_XENTR 5.00E-10 GO:0031463; GO:0016607; GO:0005634; GO:0043161; GO:0016567 Cul3-RING ubiquitin ligase complex; nuclear speck; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination IPR000210; IPR011333; IPR013069; IPR002083; IPR008974; Protein modification; protein ubiquitination. Speckle-type POZ protein spop Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40605_c3_g1_i4 Q4V7B8 RNF44_RAT 9.00E-19 GO:0008270 zinc ion binding IPR001841; IPR013083; RING finger protein 44 Rnf44 Rattus norvegicus (Rat) TR40606_c5_g2_i1 Q9NXS3 KLH28_HUMAN 2.00E-08 IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR015916; IPR017096; IPR006652; Kelch-like protein 28 (BTB/POZ domain-containing protein 5) KLHL28 BTBD5 Homo sapiens (Human) TR40606_c5_g2_i5 Q9NXS3 KLH28_HUMAN 5.00E-09 IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR015916; IPR017096; IPR006652; Kelch-like protein 28 (BTB/POZ domain-containing protein 5) KLHL28 BTBD5 Homo sapiens (Human) TR40607_c1_g1_i2 Q9P4V4 MEL_ZYGMR 3.00E-14 GO:0005975; GO:0005576; GO:0052692 carbohydrate metabolic process; extracellular region; raffinose alpha-galactosidase activity IPR013785; IPR013780; IPR002241; IPR000111; IPR006215; IPR017853; Alpha-galactosidase (EC 3.2.1.22) (Alpha-D-galactoside galactohydrolase) (MELr) (Melibiase) MEL Zygosaccharomyces mrakii (Zygotorulaspora mrakii) TR40607_c1_g1_i3 Q90744 NAGAB_CHICK 4.00E-39 GO:0008456; GO:0005975; GO:0005764 alpha-N-acetylgalactosaminidase activity; carbohydrate metabolic process; lysosome IPR013785; IPR013780; IPR002241; IPR000111; IPR017853; Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B) NAGA Gallus gallus (Chicken) TR40607_c1_g4_i1 P06280 AGAL_HUMAN 5.00E-83 GO:0005794; GO:0004557; GO:0005576; GO:0016936; GO:0016139; GO:0046477; GO:0043202; GO:0045019; GO:0051001; GO:0009311; GO:0042803; GO:0052692; GO:0005102; GO:0044281 Golgi apparatus; alpha-galactosidase activity; extracellular region; galactoside binding; glycoside catabolic process; glycosylceramide catabolic process; lysosomal lumen; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; oligosaccharide metabolic process; protein homodimerization activity; raffinose alpha-galactosidase activity; receptor binding; small molecule metabolic process IPR013785; IPR013780; IPR002241; IPR000111; IPR017853; Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Melibiase) (Agalsidase) GLA Homo sapiens (Human) TR40607_c1_g4_i2 P51569 AGAL_MOUSE 1.00E-79 GO:0005794; GO:0004557; GO:0005576; GO:0016139; GO:0046477; GO:0005764; GO:0045019; GO:0051001; GO:0009311; GO:0042803; GO:0052692; GO:0005102 Golgi apparatus; alpha-galactosidase activity; extracellular region; glycoside catabolic process; glycosylceramide catabolic process; lysosome; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; oligosaccharide metabolic process; protein homodimerization activity; raffinose alpha-galactosidase activity; receptor binding IPR013785; IPR013780; IPR002241; IPR000111; IPR017853; Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Melibiase) Gla Ags Mus musculus (Mouse) TR40608_c5_g1_i1 Q9ES45 DUOX2_RAT 0 GO:0016174; GO:0016324; GO:0005509; GO:0042335; GO:0019221; GO:0020037; GO:0042446; GO:0042744; GO:0016021; GO:0004601; GO:0051591; GO:0006590 NAD(P)H oxidase activity; apical plasma membrane; calcium ion binding; cuticle development; cytokine-mediated signaling pathway; heme binding; hormone biosynthetic process; hydrogen peroxide catabolic process; integral to membrane; peroxidase activity; response to cAMP; thyroid hormone generation IPR011992; IPR018247; IPR002048; IPR013112; IPR017927; IPR013130; IPR013121; IPR010255; IPR002007; IPR019791; IPR017938; Hormone biosynthesis; thyroid hormone biosynthesis. Dual oxidase 2 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 2) (Long NOX 2) (NADH/NADPH thyroid oxidase THOX2) (Thyroid oxidase 2) Duox2 Lnox2 Thox2 Rattus norvegicus (Rat) TR40608_c5_g1_i3 Q9VQH2 DUOX_DROME 0 GO:0016174; GO:0008365; GO:0048085; GO:0005509; GO:0019221; GO:0042742; GO:0020037; GO:0042744; GO:0016021; GO:0002385; GO:0043066; GO:0004601; GO:0072593; GO:0051591; GO:0035220 NAD(P)H oxidase activity; adult chitin-based cuticle development; adult chitin-containing cuticle pigmentation; calcium ion binding; cytokine-mediated signaling pathway; defense response to bacterium; heme binding; hydrogen peroxide catabolic process; integral to membrane; mucosal immune response; negative regulation of apoptotic process; peroxidase activity; reactive oxygen species metabolic process; response to cAMP; wing disc development IPR011992; IPR018247; IPR002048; IPR013112; IPR017927; IPR013130; IPR013121; IPR010255; IPR002007; IPR019791; IPR017938; Dual oxidase (EC 1.11.1.-) (EC 1.6.3.1) Duox CG3131 Drosophila melanogaster (Fruit fly) TR40608_c5_g1_i4 Q9ES45 DUOX2_RAT 0 GO:0016174; GO:0016324; GO:0005509; GO:0042335; GO:0019221; GO:0020037; GO:0042446; GO:0042744; GO:0016021; GO:0004601; GO:0051591; GO:0006590 NAD(P)H oxidase activity; apical plasma membrane; calcium ion binding; cuticle development; cytokine-mediated signaling pathway; heme binding; hormone biosynthetic process; hydrogen peroxide catabolic process; integral to membrane; peroxidase activity; response to cAMP; thyroid hormone generation IPR011992; IPR018247; IPR002048; IPR013112; IPR017927; IPR013130; IPR013121; IPR010255; IPR002007; IPR019791; IPR017938; Hormone biosynthesis; thyroid hormone biosynthesis. Dual oxidase 2 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 2) (Long NOX 2) (NADH/NADPH thyroid oxidase THOX2) (Thyroid oxidase 2) Duox2 Lnox2 Thox2 Rattus norvegicus (Rat) TR40608_c5_g1_i5 Q8CIY2 DUOX1_RAT 0 GO:0016174; GO:0016324; GO:0005509; GO:0042335; GO:0019221; GO:0020037; GO:0042446; GO:0042744; GO:0016021; GO:0004601; GO:0051591; GO:0006590 NAD(P)H oxidase activity; apical plasma membrane; calcium ion binding; cuticle development; cytokine-mediated signaling pathway; heme binding; hormone biosynthetic process; hydrogen peroxide catabolic process; integral to membrane; peroxidase activity; response to cAMP; thyroid hormone generation IPR011992; IPR018247; IPR002048; IPR013112; IPR017927; IPR013130; IPR013121; IPR010255; IPR002007; IPR019791; IPR017938; Hormone biosynthesis; thyroid hormone biosynthesis. Dual oxidase 1 (EC 1.11.1.-) (EC 1.6.3.1) Duox1 Rattus norvegicus (Rat) TR40608_c5_g1_i6 Q9ES45 DUOX2_RAT 0 GO:0016174; GO:0016324; GO:0005509; GO:0042335; GO:0019221; GO:0020037; GO:0042446; GO:0042744; GO:0016021; GO:0004601; GO:0051591; GO:0006590 NAD(P)H oxidase activity; apical plasma membrane; calcium ion binding; cuticle development; cytokine-mediated signaling pathway; heme binding; hormone biosynthetic process; hydrogen peroxide catabolic process; integral to membrane; peroxidase activity; response to cAMP; thyroid hormone generation IPR011992; IPR018247; IPR002048; IPR013112; IPR017927; IPR013130; IPR013121; IPR010255; IPR002007; IPR019791; IPR017938; Hormone biosynthesis; thyroid hormone biosynthesis. Dual oxidase 2 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 2) (Long NOX 2) (NADH/NADPH thyroid oxidase THOX2) (Thyroid oxidase 2) Duox2 Lnox2 Thox2 Rattus norvegicus (Rat) TR40608_c5_g1_i8 Q9ES45 DUOX2_RAT 0 GO:0016174; GO:0016324; GO:0005509; GO:0042335; GO:0019221; GO:0020037; GO:0042446; GO:0042744; GO:0016021; GO:0004601; GO:0051591; GO:0006590 NAD(P)H oxidase activity; apical plasma membrane; calcium ion binding; cuticle development; cytokine-mediated signaling pathway; heme binding; hormone biosynthetic process; hydrogen peroxide catabolic process; integral to membrane; peroxidase activity; response to cAMP; thyroid hormone generation IPR011992; IPR018247; IPR002048; IPR013112; IPR017927; IPR013130; IPR013121; IPR010255; IPR002007; IPR019791; IPR017938; Hormone biosynthesis; thyroid hormone biosynthesis. Dual oxidase 2 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 2) (Long NOX 2) (NADH/NADPH thyroid oxidase THOX2) (Thyroid oxidase 2) Duox2 Lnox2 Thox2 Rattus norvegicus (Rat) TR40608_c5_g3_i1 Q6TMK4 POXA_DICDI 3.00E-28 GO:0005576; GO:0020037; GO:0042744; GO:0006955; GO:0004601 extracellular region; heme binding; hydrogen peroxide catabolic process; immune response; peroxidase activity IPR010255; IPR002007; IPR019791; Peroxinectin A (EC 1.11.1.7) poxA DDB_G0277275 Dictyostelium discoideum (Slime mold) TR40610_c4_g1_i2 Q6T486 RBRA_DICDI 1.00E-42 GO:0016874; GO:0016567; GO:0030435; GO:0008270 ligase activity; protein ubiquitination; sporulation resulting in formation of a cellular spore; zinc ion binding IPR002867; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase rbrA (EC 6.3.2.-) (Ariadne-like ubiquitin ligase) rbrA DDB_G0286961 Dictyostelium discoideum (Slime mold) TR40610_c4_g1_i3 Q32NS4 ARI1_XENLA 8.00E-160 GO:0005737; GO:0004842; GO:0008270 cytoplasm; ubiquitin-protein ligase activity; zinc ion binding IPR002867; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase arih1 (EC 6.3.2.-) (Protein ariadne-1 homolog) (ARI-1) arih1 Xenopus laevis (African clawed frog) TR40610_c4_g3_i1 Q9FFN9 ARI13_ARATH 8.00E-17 GO:0016874; GO:0016567; GO:0008270 ligase activity; protein ubiquitination; zinc ion binding IPR002867; IPR001876; IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase ARI13 (EC 6.3.2.-) (ARIADNE-like protein ARI13) (Protein ariadne homolog 13) ARI13 At5g63750 MBK5.23 Arabidopsis thaliana (Mouse-ear cress) TR40610_c5_g2_i1 Q9MYM7 B3GT1_PONPY 7.00E-32 GO:0000139; GO:0008378; GO:0016021; GO:0006486 Golgi membrane; galactosyltransferase activity; integral to membrane; protein glycosylation IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) TR40612_c10_g1_i1 Q8K3W2 LRC10_MOUSE 2.00E-11 GO:0003779; GO:0051393; GO:0055013; GO:0005856; GO:0005739; GO:0005634; GO:0030017 actin binding; alpha-actinin binding; cardiac muscle cell development; cytoskeleton; mitochondrion; nucleus; sarcomere IPR001611; IPR025875; IPR003591; Leucine-rich repeat-containing protein 10 (Heart-restricted leucine-rich repeat protein) Lrrc10 Hrlrrp Mus musculus (Mouse) TR40612_c6_g1_i1 Q29MA5 RM24_DROPS 6.00E-57 GO:0005739; GO:0005840; GO:0003735; GO:0006412 mitochondrion; ribosome; structural constituent of ribosome; translation IPR005824; IPR014722; IPR003256; IPR005825; IPR008991; "Probable 39S ribosomal protein L24, mitochondrial (L24mt) (MRP-L24)" mRpL24 GA21365 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR40612_c7_g1_i1 A4IIK1 MFHA1_XENTR 1.00E-30 GO:0005525; GO:0007264 GTP binding; small GTPase mediated signal transduction IPR001611; IPR025875; IPR003591; IPR027417; IPR020859; IPR001806; Malignant fibrous histiocytoma-amplified sequence 1 homolog mfhas1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40612_c8_g2_i2 Q54T06 Y8206_DICDI 2.00E-39 GO:0006882; GO:0016021; GO:0046872; GO:0005385 cellular zinc ion homeostasis; integral to membrane; metal ion binding; zinc ion transmembrane transporter activity IPR002524; IPR027469; Probable zinc transporter protein DDB_G0282067 DDB_G0282067 Dictyostelium discoideum (Slime mold) TR40612_c8_g3_i1 Q3UVU3 ZNT10_MOUSE 4.00E-42 GO:0008324; GO:0016021; GO:0005886; GO:0006829 cation transmembrane transporter activity; integral to membrane; plasma membrane; zinc ion transport IPR002524; IPR027469; Zinc transporter 10 (ZnT-10) (Solute carrier family 30 member 10) Slc30a10 Znt10 Mus musculus (Mouse) TR40613_c1_g1_i1 Q556Y8 DUSPR_DICDI 1.00E-13 GO:0035335; GO:0004725; GO:0008138 peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR020422; IPR024950; IPR001763; IPR000387; IPR016130; Probable rhodanese domain-containing dual specificity protein phosphatase (EC 3.1.3.16) (EC 3.1.3.48) DDB_G0273199; DDB_G0273729 Dictyostelium discoideum (Slime mold) TR40613_c1_g2_i1 Q76I76 SSH2_HUMAN 1.00E-94 GO:0003677; GO:0003779; GO:0030036; GO:0005737; GO:0005856; GO:0035335; GO:0004725; GO:0008138; GO:0008064; GO:0050770; GO:0010591 DNA binding; actin binding; actin cytoskeleton organization; cytoplasm; cytoskeleton; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; regulation of actin polymerization or depolymerization; regulation of axonogenesis; regulation of lamellipodium assembly IPR014876; IPR000340; IPR020422; IPR024950; IPR009057; IPR000387; IPR016130; Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) SSH2 KIAA1725 SSH2L Homo sapiens (Human) TR40617_c5_g1_i3 P10079 FBP1_STRPU 9.00E-11 GO:0032579; GO:0005509; GO:0016023; GO:0005615 apical lamina of hyaline layer; calcium ion binding; cytoplasmic membrane-bounded vesicle; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) TR40617_c5_g1_i4 Q9UM47 NOTC3_HUMAN 4.00E-11 GO:0000139; GO:0007220; GO:0007219; GO:0005509; GO:0005829; GO:0005789; GO:0005576; GO:0030900; GO:0072104; GO:0016021; GO:0045665; GO:0048663; GO:0005654; GO:0005886; GO:0048661; GO:0006355; GO:0006367 Q9R1P4 "Golgi membrane; Notch receptor processing; Notch signaling pathway; calcium ion binding; cytosol; endoplasmic reticulum membrane; extracellular region; forebrain development; glomerular capillary formation; integral to membrane; negative regulation of neuron differentiation; neuron fate commitment; nucleoplasm; plasma membrane; positive regulation of smooth muscle cell proliferation; regulation of transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022331; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] NOTCH3 Homo sapiens (Human) TR40617_c5_g1_i5 Q63722 JAG1_RAT 6.00E-07 GO:0005112; GO:0007219; GO:0042491; GO:0005509; GO:0001709; GO:0016021; GO:0045596; GO:0031100; GO:0005886; GO:0042127 Q07954; Q03350 Notch binding; Notch signaling pathway; auditory receptor cell differentiation; calcium ion binding; cell fate determination; integral to membrane; negative regulation of cell differentiation; organ regeneration; plasma membrane; regulation of cell proliferation IPR001774; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR026219; IPR011651; IPR001007; Protein jagged-1 (Jagged1) (CD antigen CD339) Jag1 Rattus norvegicus (Rat) TR40617_c5_g1_i7 Q9ERB4 CSPG2_RAT 3.00E-07 GO:0031103; GO:0005509; GO:0030246; GO:0007155; GO:0006928; GO:0031012; GO:0005540; GO:0030169; GO:0005578 axon regeneration; calcium ion binding; carbohydrate binding; cell adhesion; cellular component movement; extracellular matrix; hyaluronic acid binding; low-density lipoprotein particle binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) (Fragments) Vcan Cspg2 Rattus norvegicus (Rat) TR40617_c5_g2_i2 Q90953 CSPG2_CHICK 1.00E-11 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Gallus gallus (Chicken) TR40618_c0_g1_i1 Q54TA1 DRKC_DICDI 3.00E-22 GO:0005524; GO:0016021; GO:0030670; GO:0032010; GO:0001845; GO:0004674; GO:0004713 ATP binding; integral to membrane; phagocytic vesicle membrane; phagolysosome; phagolysosome assembly; protein serine/threonine kinase activity; protein tyrosine kinase activity IPR013783; IPR014756; IPR002909; IPR011009; IPR000719; IPR001245; IPR008271; Probable serine/threonine-protein kinase drkC (EC 2.7.11.1) (Receptor-like kinase 3) (Receptor-like kinase C) (Vesicle-associated receptor tyrosine kinase-like protein 3) drkC rk3 DDB_G0281899 Dictyostelium discoideum (Slime mold) TR40618_c0_g1_i2 P36896 ACV1B_HUMAN 8.00E-162 GO:0005524; GO:0000082; GO:0046332; GO:0016361; GO:0009986; GO:0007417; GO:0046545; GO:0097191; GO:0001942; GO:0001701; GO:0005887; GO:0046872; GO:0030308; GO:0038092; GO:0018107; GO:0032927; GO:0045648; GO:0010862; GO:0045944; GO:1901165; GO:0046777; GO:0004702; GO:0006355; GO:0005024; GO:0031625 P62942; P08238; O15105 "ATP binding; G1/S transition of mitotic cell cycle; SMAD binding; activin receptor activity, type I; cell surface; central nervous system development; development of primary female sexual characteristics; extrinsic apoptotic signaling pathway; hair follicle development; in utero embryonic development; integral to plasma membrane; metal ion binding; negative regulation of cell growth; nodal signaling pathway; peptidyl-threonine phosphorylation; positive regulation of activin receptor signaling pathway; positive regulation of erythrocyte differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of trophoblast cell migration; protein autophosphorylation; receptor signaling protein serine/threonine kinase activity; regulation of transcription, DNA-dependent; transforming growth factor beta-activated receptor activity; ubiquitin protein ligase binding" IPR000472; IPR011009; IPR000719; IPR017441; IPR008271; IPR003605; Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2) ACVR1B ACVRLK4 ALK4 Homo sapiens (Human) TR40618_c0_g1_i4 O46680 TGFR1_BOVIN 3.00E-177 GO:0005524; GO:0000186; GO:0001525; GO:0009952; GO:0006915; GO:0048844; GO:0001824; GO:0030199; GO:0048701; GO:0043542; GO:0001837; GO:0008354; GO:0007507; GO:0016021; GO:0001822; GO:0002088; GO:0046872; GO:0043066; GO:0032331; GO:0001937; GO:2001237; GO:0048663; GO:0060021; GO:0060017; GO:0060389; GO:0018105; GO:0018107; GO:0060037; GO:0005886; GO:0060391; GO:2001235; GO:0030307; GO:0008284; GO:0051272; GO:0051491; GO:0010862; GO:0051897; GO:0045893; GO:0009791; GO:0043235; GO:0043393; GO:0031396; GO:0070723; GO:0048538; GO:0005923; GO:0005025; GO:0007179 "ATP binding; activation of MAPKK activity; angiogenesis; anterior/posterior pattern specification; apoptotic process; artery morphogenesis; blastocyst development; collagen fibril organization; embryonic cranial skeleton morphogenesis; endothelial cell migration; epithelial to mesenchymal transition; germ cell migration; heart development; integral to membrane; kidney development; lens development in camera-type eye; metal ion binding; negative regulation of apoptotic process; negative regulation of chondrocyte differentiation; negative regulation of endothelial cell proliferation; negative regulation of extrinsic apoptotic signaling pathway; neuron fate commitment; palate development; parathyroid gland development; pathway-restricted SMAD protein phosphorylation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pharyngeal system development; plasma membrane; positive regulation of SMAD protein import into nucleus; positive regulation of apoptotic signaling pathway; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cellular component movement; positive regulation of filopodium assembly; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of transcription, DNA-dependent; post-embryonic development; receptor complex; regulation of protein binding; regulation of protein ubiquitination; response to cholesterol; thymus development; tight junction; transforming growth factor beta receptor activity, type I; transforming growth factor beta receptor signaling pathway" IPR000472; IPR011009; IPR000719; IPR017441; IPR008271; IPR003605; TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) TGFBR1 Bos taurus (Bovine) TR40619_c1_g1_i1 Q9R045 ANGL2_MOUSE 6.00E-60 GO:0005576 extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-related protein 2 (Angiopoietin-like protein 2) Angptl2 Arp2 Mus musculus (Mouse) TR40619_c1_g1_i2 Q9WTS8 FCN1_RAT 9.00E-50 GO:0005581; GO:0045087; GO:0046872 collagen; innate immune response; metal ion binding IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) Fcn1 Fcna Rattus norvegicus (Rat) TR4062_c0_g2_i1 Q9UBF6 RBX2_HUMAN 4.00E-43 GO:0031466; GO:0019788; GO:0005507; GO:0005737; GO:0008631; GO:0043066; GO:0005634; GO:0045116; GO:0016567; GO:0051775; GO:0008270 Q96Q27; Q9Y6K9; P12504 Cul5-RING ubiquitin ligase complex; NEDD8 ligase activity; copper ion binding; cytoplasm; intrinsic apoptotic signaling pathway in response to oxidative stress; negative regulation of apoptotic process; nucleus; protein neddylation; protein ubiquitination; response to redox state; zinc ion binding IPR001841; IPR013083; IPR024766; Protein modification; protein ubiquitination. RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein) RNF7 RBX2 ROC2 SAG Homo sapiens (Human) TR40620_c0_g1_i1 Q8BSS9 LIPA2_MOUSE 0 GO:0009986; GO:0005737; GO:0045202 cell surface; cytoplasm; synapse IPR001660; IPR013761; IPR011510; IPR021129; Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2) Ppfia2 Mus musculus (Mouse) TR40620_c0_g1_i3 O75335 LIPA4_HUMAN 1.00E-153 GO:0007154; GO:0009986; GO:0005737; GO:0005622 cell communication; cell surface; cytoplasm; intracellular IPR001660; IPR013761; IPR011510; IPR021129; Liprin-alpha-4 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4) (PTPRF-interacting protein alpha-4) PPFIA4 KIAA0897 Homo sapiens (Human) TR40620_c0_g1_i4 Q13136 LIPA1_HUMAN 4.00E-156 GO:0007160; GO:0005737; GO:0004871 P19491; P97879; Q9NS73; Q14738 cell-matrix adhesion; cytoplasm; signal transducer activity IPR001660; IPR013761; IPR011510; IPR021129; Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) PPFIA1 LIP1 Homo sapiens (Human) TR40620_c0_g1_i6 Q13136 LIPA1_HUMAN 1.00E-158 GO:0007160; GO:0005737; GO:0004871 P19491; P97879; Q9NS73; Q14738 cell-matrix adhesion; cytoplasm; signal transducer activity IPR001660; IPR013761; IPR011510; IPR021129; Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) PPFIA1 LIP1 Homo sapiens (Human) TR40621_c0_g1_i1 Q8BGQ6 K0494_MOUSE 2.00E-06 GO:0046872 metal ion binding EF-hand calcium-binding domain-containing protein 14 Efcab14 Kiaa0494 Mus musculus (Mouse) TR40622_c2_g1_i2 P56960 EXOSX_MOUSE 0 GO:0008408; GO:0071034; GO:0003723; GO:0005737; GO:0009048; GO:0004532; GO:0000178; GO:0071044; GO:0000460; GO:0000176; GO:0071035; GO:0071048; GO:0000184; GO:0090305; GO:0005730; GO:0000166; GO:0035327 "3'-5' exonuclease activity; CUT catabolic process; RNA binding; cytoplasm; dosage compensation by inactivation of X chromosome; exoribonuclease activity; exosome (RNase complex); histone mRNA catabolic process; maturation of 5.8S rRNA; nuclear exosome (RNase complex); nuclear polyadenylation-dependent rRNA catabolic process; nuclear retention of unspliced pre-mRNA at the site of transcription; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleic acid phosphodiester bond hydrolysis; nucleolus; nucleotide binding; transcriptionally active chromatin" IPR002562; IPR012588; IPR010997; IPR002121; IPR012337; Exosome component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2 homolog) (Polymyositis/scleroderma autoantigen 2 homolog) Exosc10 Pmscl2 Mus musculus (Mouse) TR40623_c0_g1_i3 O17468 HIRA_DROME 1.00E-24 GO:0006336; GO:0003682; GO:0035042; GO:0042585; GO:0001673; GO:0006355; GO:0006351 "DNA replication-independent nucleosome assembly; chromatin binding; fertilization, exchange of chromosomal proteins; germinal vesicle; male germ cell nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR020472; IPR011494; IPR019015; IPR015943; IPR001680; IPR019775; IPR017986; Protein HIRA homolog (Protein sesame) (dHIRA) Hira Dhh ssm CG12153 Drosophila melanogaster (Fruit fly) TR40623_c1_g1_i1 Q8QFR2 HIRA_XENLA 2.00E-84 GO:0003682; GO:0016568; GO:0005634; GO:0006355; GO:0006351 "chromatin binding; chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011494; IPR019015; IPR015943; IPR001680; IPR019775; IPR017986; Protein HIRA hira hira-a Xenopus laevis (African clawed frog) TR40623_c1_g1_i2 Q9LXN4 HIRA_ARATH 2.00E-36 GO:0016568; GO:0005634; GO:0006355; GO:0006351 "chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011494; IPR015943; IPR001680; IPR019775; IPR017986; Protein HIRA (Histone regulator protein) HIRA At3g44530 F14L2.80 Arabidopsis thaliana (Mouse-ear cress) TR40625_c2_g1_i1 A2AJ76 HMCN2_MOUSE 6.00E-36 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 Hmcn2 Mus musculus (Mouse) TR40625_c2_g1_i2 P15364 AMAL_DROME 2.00E-31 GO:0031225; GO:0005886 anchored to membrane; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Protein amalgam Ama CG2198 Drosophila melanogaster (Fruit fly) TR40625_c2_g1_i3 P21803 FGFR2_MOUSE 3.00E-08 GO:0005524; GO:0005794; GO:0001525; GO:0006915; GO:0007409; GO:0030282; GO:0060667; GO:0060670; GO:0048755; GO:0060449; GO:0045165; GO:0060365; GO:0016023; GO:0048701; GO:0048557; GO:0009880; GO:0061031; GO:0060664; GO:0060076; GO:0005576; GO:0017134; GO:0035603; GO:0060595; GO:0035602; GO:0035607; GO:0035604; GO:0005007; GO:0031069; GO:0008201; GO:0016021; GO:0032808; GO:0060601; GO:0070307; GO:0060174; GO:0048286; GO:0060463; GO:0060484; GO:0060615; GO:0003149; GO:0060915; GO:0060916; GO:0030901; GO:0035264; GO:0008285; GO:0045839; GO:0000122; GO:0007528; GO:0005634; GO:0042476; GO:0035265; GO:0030916; GO:0003148; GO:0018108; GO:0005886; GO:0070374; GO:0090263; GO:0060045; GO:0045787; GO:0051781; GO:0060501; GO:0002053; GO:0045944; GO:0009791; GO:0060527; GO:0060523; GO:0021860; GO:0060687; GO:0010453; GO:0040036; GO:0040014; GO:0051150; GO:0008589; GO:0060529; GO:0048489; GO:0001657; GO:0060979; GO:0055010; GO:0021847 ATP binding; Golgi apparatus; angiogenesis; apoptotic process; axonogenesis; bone mineralization; branch elongation involved in salivary gland morphogenesis; branching involved in labyrinthine layer morphogenesis; branching morphogenesis of a nerve; bud elongation involved in lung branching; cell fate commitment; coronal suture morphogenesis; cytoplasmic membrane-bounded vesicle; embryonic cranial skeleton morphogenesis; embryonic digestive tract morphogenesis; embryonic pattern specification; endodermal digestive tract morphogenesis; epithelial cell proliferation involved in salivary gland morphogenesis; excitatory synapse; extracellular region; fibroblast growth factor binding; fibroblast growth factor receptor signaling pathway involved in hemopoiesis; fibroblast growth factor receptor signaling pathway involved in mammary gland specification; fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow; fibroblast growth factor-activated receptor activity; hair follicle morphogenesis; heparin binding; integral to membrane; lacrimal gland development; lateral sprouting from an epithelium; lens fiber cell development; limb bud formation; lung alveolus development; lung lobe morphogenesis; lung-associated mesenchyme development; mammary gland bud formation; membranous septum morphogenesis; mesenchymal cell differentiation involved in lung development; mesenchymal cell proliferation involved in lung development; midbrain development; multicellular organism growth; negative regulation of cell proliferation; negative regulation of mitosis; negative regulation of transcription from RNA polymerase II promoter; neuromuscular junction development; nucleus; odontogenesis; organ growth; otic vesicle formation; outflow tract septum morphogenesis; peptidyl-tyrosine phosphorylation; plasma membrane; positive regulation of ERK1 and ERK2 cascade; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle; positive regulation of cell division; positive regulation of epithelial cell proliferation involved in lung morphogenesis; positive regulation of mesenchymal cell proliferation; positive regulation of transcription from RNA polymerase II promoter; post-embryonic development; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; prostate epithelial cord elongation; pyramidal neuron development; regulation of branching involved in prostate gland morphogenesis; regulation of cell fate commitment; regulation of fibroblast growth factor receptor signaling pathway; regulation of multicellular organism growth; regulation of smooth muscle cell differentiation; regulation of smoothened signaling pathway; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; synaptic vesicle transport; ureteric bud development; vasculogenesis involved in coronary vascular morphogenesis; ventricular cardiac muscle tissue morphogenesis; ventricular zone neuroblast division IPR028175; IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (Keratinocyte growth factor receptor) (KGFR) (CD antigen CD332) Fgfr2 Bek Ect1 Mus musculus (Mouse) TR40626_c0_g2_i2 Q7ZY69 PESC_XENLA 0 GO:0070545; GO:0008283; GO:0000466; GO:0000463; GO:0005654; GO:0030687 "PeBoW complex; cell proliferation; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleoplasm; preribosome, large subunit precursor" IPR001357; IPR010613; Pescadillo homolog pes1 Xenopus laevis (African clawed frog) TR40626_c0_g2_i3 P79741 PESC_DANRE 0 GO:0070545; GO:0008283; GO:0031017; GO:0000466; GO:0000463; GO:0005654; GO:0048709; GO:0030687; GO:0051726 "PeBoW complex; cell proliferation; exocrine pancreas development; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleoplasm; oligodendrocyte differentiation; preribosome, large subunit precursor; regulation of cell cycle" IPR001357; IPR010613; Pescadillo pes si:dkeyp-86g2.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR40628_c3_g1_i1 O94623 REV1_SCHPO 1.00E-09 GO:0006260; GO:0003887; GO:0003684; GO:0017125; GO:0000287; GO:0043504; GO:0005739; GO:0005730; GO:0035861; GO:0005819 DNA replication; DNA-directed DNA polymerase activity; damaged DNA binding; deoxycytidyl transferase activity; magnesium ion binding; mitochondrial DNA repair; mitochondrion; nucleolus; site of double-strand break; spindle IPR001357; IPR017961; IPR001126; IPR017963; IPR012112; DNA repair protein rev1 (EC 2.7.7.-) (Reversionless protein 1) rev1 SPBC1347.01c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40628_c3_g1_i2 P18887 XRCC1_HUMAN 3.00E-53 GO:0006284; GO:0003684; GO:0021766; GO:0005654; GO:0042493; GO:0001666; GO:0010033; GO:0000012 Q8IW19; Q7Z2E3; O96017; P09874; Q96T60; Q9UNA4 base-excision repair; damaged DNA binding; hippocampus development; nucleoplasm; response to drug; response to hypoxia; response to organic substance; single strand break repair IPR001357; IPR008979; IPR002706; DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) XRCC1 Homo sapiens (Human) TR40628_c3_g1_i3 Q7ZU90 CHD1L_DANRE 3.00E-07 GO:0005524; GO:0016887; GO:0003677; GO:0006281; GO:0006338; GO:0004386; GO:0000166; GO:0005634; GO:0006974 ATP binding; ATPase activity; DNA binding; DNA repair; chromatin remodeling; helicase activity; nucleotide binding; nucleus; response to DNA damage stimulus IPR001357; IPR014001; IPR001650; IPR002589; IPR027417; IPR000330; Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.12) chd1l zgc:56084 Danio rerio (Zebrafish) (Brachydanio rerio) TR40628_c3_g1_i4 P18887 XRCC1_HUMAN 2.00E-52 GO:0006284; GO:0003684; GO:0021766; GO:0005654; GO:0042493; GO:0001666; GO:0010033; GO:0000012 Q8IW19; Q7Z2E3; O96017; P09874; Q96T60; Q9UNA4 base-excision repair; damaged DNA binding; hippocampus development; nucleoplasm; response to drug; response to hypoxia; response to organic substance; single strand break repair IPR001357; IPR008979; IPR002706; DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) XRCC1 Homo sapiens (Human) TR40631_c2_g3_i1 Q9BXX0 EMIL2_HUMAN 1.00E-06 GO:0007155; GO:0005581; GO:0030023; GO:0005576 cell adhesion; collagen; extracellular matrix constituent conferring elasticity; extracellular region IPR001073; IPR011489; IPR008983; EMILIN-2 (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10) EMILIN2 Homo sapiens (Human) TR40633_c0_g1_i1 Q9CVD2 ATX3_MOUSE 1.00E-92 GO:0001012; GO:0034605; GO:0071218; GO:0035640; GO:0070932; GO:0006515; GO:0005759; GO:0031966; GO:0035520; GO:0042405; GO:0008242; GO:0043161; GO:0010810; GO:0006355; GO:0006351; GO:0004221; GO:0004843 "RNA polymerase II regulatory region DNA binding; cellular response to heat; cellular response to misfolded protein; exploration behavior; histone H3 deacetylation; misfolded or incompletely synthesized protein catabolic process; mitochondrial matrix; mitochondrial membrane; monoubiquitinated protein deubiquitination; nuclear inclusion body; omega peptidase activity; proteasomal ubiquitin-dependent protein catabolic process; regulation of cell-substrate adhesion; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin thiolesterase activity; ubiquitin-specific protease activity" IPR006155; IPR003903; Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1 homolog) Atxn3 Mjd Mus musculus (Mouse) TR40633_c0_g1_i5 Q9CVD2 ATX3_MOUSE 1.00E-92 GO:0001012; GO:0034605; GO:0071218; GO:0035640; GO:0070932; GO:0006515; GO:0005759; GO:0031966; GO:0035520; GO:0042405; GO:0008242; GO:0043161; GO:0010810; GO:0006355; GO:0006351; GO:0004221; GO:0004843 "RNA polymerase II regulatory region DNA binding; cellular response to heat; cellular response to misfolded protein; exploration behavior; histone H3 deacetylation; misfolded or incompletely synthesized protein catabolic process; mitochondrial matrix; mitochondrial membrane; monoubiquitinated protein deubiquitination; nuclear inclusion body; omega peptidase activity; proteasomal ubiquitin-dependent protein catabolic process; regulation of cell-substrate adhesion; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin thiolesterase activity; ubiquitin-specific protease activity" IPR006155; IPR003903; Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1 homolog) Atxn3 Mjd Mus musculus (Mouse) TR40634_c3_g2_i1 Q4H3K6 FGFR_CIOIN 2.00E-07 GO:0005524; GO:0005007; GO:0016021; GO:0060173; GO:0018108; GO:0008284 ATP binding; fibroblast growth factor-activated receptor activity; integral to membrane; limb development; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation IPR028174; IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor (Ci-FGFR) (EC 2.7.10.1) FGFR Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) TR40634_c4_g2_i1 Q96RW7 HMCN1_HUMAN 2.00E-49 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR40634_c4_g2_i2 A2AJ76 HMCN2_MOUSE 8.00E-32 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 Hmcn2 Mus musculus (Mouse) TR40636_c0_g4_i1 H2A0M3 AMO_PINMG 8.00E-94 GO:0009308; GO:0005507; GO:0005576; GO:0008131; GO:0048038 amine metabolic process; copper ion binding; extracellular region; primary amine oxidase activity; quinone binding IPR000269; IPR015798; IPR016182; IPR015801; Putative amine oxidase [copper-containing] (EC 1.4.3.-) Pinctada margaritifera (Black-lipped pearl oyster) TR40637_c0_g1_i3 P40796 LA_DROME 3.00E-39 GO:0008098; GO:0003677; GO:0006396; GO:0003729; GO:0000166; GO:0005634; GO:0030529 5S rRNA primary transcript binding; DNA binding; RNA processing; mRNA binding; nucleotide binding; nucleus; ribonucleoprotein complex IPR002344; IPR006630; IPR012677; IPR014886; IPR000504; IPR011991; La protein homolog (La autoantigen homolog) (La ribonucleoprotein) La CG10922 Drosophila melanogaster (Fruit fly) TR40637_c0_g1_i5 P10881 LA_BOVIN 3.00E-45 GO:0003723; GO:0006396; GO:0000166; GO:0005634; GO:0030529 RNA binding; RNA processing; nucleotide binding; nucleus; ribonucleoprotein complex IPR002344; IPR006630; IPR012677; IPR014886; IPR000504; IPR011991; Lupus La protein homolog (La autoantigen homolog) (La ribonucleoprotein) SSB Bos taurus (Bovine) TR40637_c0_g1_i8 P28049 LAB_XENLA 8.00E-33 GO:0003723; GO:0006396; GO:0000166; GO:0005634; GO:0030529 RNA binding; RNA processing; nucleotide binding; nucleus; ribonucleoprotein complex IPR002344; IPR006630; IPR012677; IPR014886; IPR000504; IPR011991; Lupus La protein homolog B (La autoantigen homolog B) (La ribonucleoprotein B) ssb-b lab1 Xenopus laevis (African clawed frog) TR40639_c2_g1_i1 Q23424 FZO1_CAEEL 2.00E-55 GO:0005525; GO:0003924; GO:0016021; GO:0008053; GO:0005741 GTP binding; GTPase activity; integral to membrane; mitochondrial fusion; mitochondrial outer membrane IPR001401; IPR006884; IPR027091; IPR027094; IPR027417; Transmembrane GTPase fzo-1 (EC 3.6.5.-) fzo-1 ZK1248.14 Caenorhabditis elegans TR40639_c3_g2_i2 Q8R500 MFN2_RAT 2.00E-66 GO:0005525; GO:0003924; GO:0005829; GO:0016021; GO:0031306; GO:0008053; GO:0007006; GO:0048662; GO:0006626 GTP binding; GTPase activity; cytosol; integral to membrane; intrinsic to mitochondrial outer membrane; mitochondrial fusion; mitochondrial membrane organization; negative regulation of smooth muscle cell proliferation; protein targeting to mitochondrion IPR001401; IPR006884; IPR027089; IPR027094; IPR027417; Mitofusin-2 (EC 3.6.5.-) (Mitochondrial transmembrane GTPase FZO1A) (Protein HSG) (Transmembrane GTPase MFN2) Mfn2 Fzo1a Rattus norvegicus (Rat) TR40640_c2_g3_i2 Q32NQ8 RNF10_XENLA 3.00E-07 GO:0005737; GO:0010626; GO:0005634; GO:0031643; GO:0045944; GO:0044212; GO:0006351; GO:0008270 "cytoplasm; negative regulation of Schwann cell proliferation; nucleus; positive regulation of myelination; positive regulation of transcription from RNA polymerase II promoter; transcription regulatory region DNA binding; transcription, DNA-dependent; zinc ion binding" IPR001841; IPR013083; IPR017907; RING finger protein 10 rnf10 Xenopus laevis (African clawed frog) TR40640_c2_g3_i3 Q32NQ8 RNF10_XENLA 8.00E-93 GO:0005737; GO:0010626; GO:0005634; GO:0031643; GO:0045944; GO:0044212; GO:0006351; GO:0008270 "cytoplasm; negative regulation of Schwann cell proliferation; nucleus; positive regulation of myelination; positive regulation of transcription from RNA polymerase II promoter; transcription regulatory region DNA binding; transcription, DNA-dependent; zinc ion binding" IPR001841; IPR013083; IPR017907; RING finger protein 10 rnf10 Xenopus laevis (African clawed frog) TR40640_c2_g3_i5 Q08E13 RNF10_BOVIN 1.00E-112 GO:0005737; GO:0045893; GO:0008270 "cytoplasm; positive regulation of transcription, DNA-dependent; zinc ion binding" IPR001841; IPR013083; IPR017907; RING finger protein 10 RNF10 Bos taurus (Bovine) TR40640_c2_g3_i6 Q08E13 RNF10_BOVIN 2.00E-112 GO:0005737; GO:0045893; GO:0008270 "cytoplasm; positive regulation of transcription, DNA-dependent; zinc ion binding" IPR001841; IPR013083; IPR017907; RING finger protein 10 RNF10 Bos taurus (Bovine) TR40641_c1_g1_i1 Q5RFQ3 PWP2_PONAB 0 GO:0005730 nucleolus IPR027145; IPR011047; IPR007148; IPR015943; IPR001680; IPR019775; IPR017986; Periodic tryptophan protein 2 homolog PWP2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40641_c1_g1_i3 Q5RFQ3 PWP2_PONAB 3.00E-68 GO:0005730 nucleolus IPR027145; IPR011047; IPR007148; IPR015943; IPR001680; IPR019775; IPR017986; Periodic tryptophan protein 2 homolog PWP2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40643_c0_g1_i1 Q5R563 RENR_PONAB 5.00E-08 GO:0004190; GO:0009897; GO:0016021; GO:0032914; GO:0004872; GO:0043408 aspartic-type endopeptidase activity; external side of plasma membrane; integral to membrane; positive regulation of transforming growth factor beta1 production; receptor activity; regulation of MAPK cascade IPR012493; Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (Renin/prorenin receptor) ATP6AP2 ATP6IP2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40643_c0_g3_i3 P81134 RENR_BOVIN 2.00E-50 GO:0016021; GO:0004872 integral to membrane; receptor activity IPR012493; Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (V-ATPase M8.9 subunit) ATP6AP2 ATP6IP2 Bos taurus (Bovine) TR40644_c0_g1_i1 D7REX8 UN45B_XENTR 2.00E-74 GO:0030154; GO:0005829; GO:0007517 cell differentiation; cytosol; muscle organ development IPR011989; IPR016024; IPR000225; IPR013026; IPR011990; IPR001440; IPR019734; IPR024660; Protein unc-45 homolog B (Unc-45B) unc45b cmya4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40644_c0_g3_i1 Q5RAP0 UN45A_PONAB 2.00E-112 GO:0030154; GO:0007517; GO:0005634; GO:0048471 cell differentiation; muscle organ development; nucleus; perinuclear region of cytoplasm IPR011989; IPR016024; IPR013026; IPR011990; IPR013105; IPR019734; IPR024660; Protein unc-45 homolog A (Unc-45A) (Smooth muscle cell-associated protein 1) (SMAP-1) UNC45A SMAP1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40644_c0_g3_i3 O74994 RNG3_SCHPO 2.00E-14 GO:0005826; GO:0000917; GO:0034613; GO:0000915; GO:0005829; GO:0017022; GO:0005634; GO:0005844; GO:0043234 "actomyosin contractile ring; barrier septum assembly; cellular protein localization; cytokinesis, actomyosin contractile ring assembly; cytosol; myosin binding; nucleus; polysome; protein complex" IPR011989; IPR016024; IPR024660; Ring assembly protein 3 rng3 SPCC613.04c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40647_c3_g1_i1 Q0V9K2 ABHDB_XENTR 2.00E-67 GO:0016787 hydrolase activity Alpha/beta hydrolase domain-containing protein 11 (Abhydrolase domain-containing protein 11) (EC 3.-.-.-) abhd11 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40647_c3_g1_i13 Q9XT62 RAD17_CHLAE 3.00E-35 GO:0005524; GO:0006281; GO:0007049; GO:0005634 ATP binding; DNA repair; cell cycle; nucleus IPR004582; IPR018324; IPR027417; Cell cycle checkpoint protein RAD17 RAD17 Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) TR40647_c3_g1_i14 Q6DRD9 ABHDB_DANRE 2.00E-73 GO:0016787 hydrolase activity IPR000073; Alpha/beta hydrolase domain-containing protein 11 (Abhydrolase domain-containing protein 11) (EC 3.-.-.-) (Williams-Beuren syndrome chromosomal region 21 protein homolog) abhd11 wbscr21 Danio rerio (Zebrafish) (Brachydanio rerio) TR40647_c3_g1_i2 P0A573 Y2734_MYCBO 1.00E-12 GO:0016787; GO:0008152 hydrolase activity; metabolic process IPR000073; IPR000639; Uncharacterized protein Mb2734 Mb2734 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) TR40647_c3_g1_i3 Q6DRD9 ABHDB_DANRE 3.00E-75 GO:0016787 hydrolase activity IPR000073; Alpha/beta hydrolase domain-containing protein 11 (Abhydrolase domain-containing protein 11) (EC 3.-.-.-) (Williams-Beuren syndrome chromosomal region 21 protein homolog) abhd11 wbscr21 Danio rerio (Zebrafish) (Brachydanio rerio) TR40647_c3_g1_i5 P23974 YTXM_BACSU 3.00E-13 GO:0070205; GO:0004091; GO:0009234 "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity; carboxylesterase activity; menaquinone biosynthetic process" IPR000073; IPR000639; IPR022485; Putative esterase YtxM (EC 3.1.-.-) ytxM ytfB BSU30810 Bacillus subtilis (strain 168) TR40647_c7_g1_i1 Q8SV95 Z6B5_ENCCU 2.00E-06 GO:0046872; GO:0003676 metal ion binding; nucleic acid binding IPR007087; IPR015880; IPR013087; Zinc finger C2H2 protein ECU06_1150 ECU06_1150 Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) TR40647_c8_g1_i1 Q8TF20 ZN721_HUMAN 3.00E-30 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 721 ZNF721 KIAA1982 Homo sapiens (Human) TR40648_c3_g4_i1 O64640 CXE8_ARATH 4.00E-06 GO:0004091 carboxylesterase activity IPR013094; IPR002168; Probable carboxylesterase 8 (AtCXE8) (EC 3.1.1.1) CXE8 At2g45600 17K2.13 Arabidopsis thaliana (Mouse-ear cress) TR40648_c3_g4_i2 P71667 NLHH_MYCTU 2.00E-35 GO:0004091; GO:0009056; GO:0034338 carboxylesterase activity; catabolic process; short-chain carboxylesterase activity IPR013094; Carboxylesterase NlhH (EC 3.1.1.1) nlhH lipH Rv1399c MT1443 Mycobacterium tuberculosis TR4065_c0_g1_i1 A6LM32 DNAK_THEM4 3.00E-16 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK Tmel_1128 Thermosipho melanesiensis (strain BI429 / DSM 12029) TR40650_c1_g1_i1 P55265 DSRAD_HUMAN 2.00E-21 GO:0003677; GO:0003723; GO:0006382; GO:0005737; GO:0051607; GO:0003726; GO:0010467; GO:0031047; GO:0016556; GO:0006397; GO:0046872; GO:0043066; GO:0044387; GO:0005730; GO:0005654; GO:0005634; GO:0045070; GO:0006611; GO:0006606; GO:0035455; GO:0009615; GO:0044530; GO:0060337 Q99IB8; Q9UPY3; Q15633 DNA binding; RNA binding; adenosine to inosine editing; cytoplasm; defense response to virus; double-stranded RNA adenosine deaminase activity; gene expression; gene silencing by RNA; mRNA modification; mRNA processing; metal ion binding; negative regulation of apoptotic process; negative regulation of protein kinase activity by regulation of protein phosphorylation; nucleolus; nucleoplasm; nucleus; positive regulation of viral genome replication; protein export from nucleus; protein import into nucleus; response to interferon-alpha; response to virus; supraspliceosomal complex; type I interferon-mediated signaling pathway IPR002466; IPR014720; IPR000607; IPR011991; Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) ADAR ADAR1 DSRAD G1P1 IFI4 Homo sapiens (Human) TR40650_c1_g2_i2 P55265 DSRAD_HUMAN 3.00E-88 GO:0003677; GO:0003723; GO:0006382; GO:0005737; GO:0051607; GO:0003726; GO:0010467; GO:0031047; GO:0016556; GO:0006397; GO:0046872; GO:0043066; GO:0044387; GO:0005730; GO:0005654; GO:0005634; GO:0045070; GO:0006611; GO:0006606; GO:0035455; GO:0009615; GO:0044530; GO:0060337 Q99IB8; Q9UPY3; Q15633 DNA binding; RNA binding; adenosine to inosine editing; cytoplasm; defense response to virus; double-stranded RNA adenosine deaminase activity; gene expression; gene silencing by RNA; mRNA modification; mRNA processing; metal ion binding; negative regulation of apoptotic process; negative regulation of protein kinase activity by regulation of protein phosphorylation; nucleolus; nucleoplasm; nucleus; positive regulation of viral genome replication; protein export from nucleus; protein import into nucleus; response to interferon-alpha; response to virus; supraspliceosomal complex; type I interferon-mediated signaling pathway IPR002466; IPR014720; IPR000607; IPR011991; Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) ADAR ADAR1 DSRAD G1P1 IFI4 Homo sapiens (Human) TR40650_c1_g2_i3 Q9V3R6 ADAT1_DROME 6.00E-22 GO:0003723; GO:0046872; GO:0006400; GO:0008251 RNA binding; metal ion binding; tRNA modification; tRNA-specific adenosine deaminase activity IPR002466; tRNA-specific adenosine deaminase 1 (EC 3.5.4.34) (dADAT1) (tRNA-specific adenosine-37 deaminase) adat CG16889 Drosophila melanogaster (Fruit fly) TR40650_c1_g4_i1 P78563 RED1_HUMAN 3.00E-44 GO:0003723; GO:0006396; GO:0004000; GO:0006382; GO:0016553; GO:0051607; GO:0003726; GO:0003725; GO:0010467; GO:0045087; GO:0003729; GO:0016556; GO:0006397; GO:0046872; GO:0030336; GO:0008285; GO:0044387; GO:0005730; GO:0005654; GO:0005634; GO:0045070; GO:0051726 Q13526; O00308 RNA binding; RNA processing; adenosine deaminase activity; adenosine to inosine editing; base conversion or substitution editing; defense response to virus; double-stranded RNA adenosine deaminase activity; double-stranded RNA binding; gene expression; innate immune response; mRNA binding; mRNA modification; mRNA processing; metal ion binding; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of protein kinase activity by regulation of protein phosphorylation; nucleolus; nucleoplasm; nucleus; positive regulation of viral genome replication; regulation of cell cycle IPR002466; IPR008996; IPR014720; Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) ADARB1 ADAR2 DRADA2 RED1 Homo sapiens (Human) TR40650_c1_g4_i2 Q5ZI16 ADAT1_CHICK 8.00E-13 GO:0003723; GO:0046872; GO:0008033; GO:0008251 RNA binding; metal ion binding; tRNA processing; tRNA-specific adenosine deaminase activity IPR002466; tRNA-specific adenosine deaminase 1 (EC 3.5.4.34) (tRNA-specific adenosine-37 deaminase) ADAT1 RCJMB04_31g18 Gallus gallus (Chicken) TR40650_c1_g4_i3 Q5SUE7 ADAD1_MOUSE 9.00E-24 GO:0003723; GO:0006396; GO:0004000; GO:0007275; GO:0005634; GO:0007286 RNA binding; RNA processing; adenosine deaminase activity; multicellular organismal development; nucleus; spermatid development IPR002466; IPR014720; Adenosine deaminase domain-containing protein 1 (Testis nuclear RNA-binding protein) Adad1 Tenr Mus musculus (Mouse) TR40651_c5_g2_i2 P29341 PABP1_MOUSE 5.00E-07 GO:0008380; GO:0010494; GO:0031047; GO:0006397; GO:2000623; GO:0000184; GO:0000166; GO:0008143; GO:1900153; GO:0060213; GO:0005681 "RNA splicing; cytoplasmic stress granule; gene silencing by RNA; mRNA processing; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleotide binding; poly(A) RNA binding; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; spliceosomal complex" IPR012677; IPR006515; IPR002004; IPR000504; Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) Pabpc1 Pabp1 Mus musculus (Mouse) TR40651_c5_g2_i3 Q5R7X2 SR140_PONAB 0 GO:0003723; GO:0006396; GO:0000166; GO:0005634 RNA binding; RNA processing; nucleotide binding; nucleus IPR006569; IPR008942; IPR013170; IPR012677; IPR000504; IPR000061; U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) U2SURP SR140 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40651_c5_g2_i4 Q6NV83 SR140_MOUSE 0 GO:0003723; GO:0006396; GO:0000166; GO:0005634 RNA binding; RNA processing; nucleotide binding; nucleus IPR006569; IPR008942; IPR013170; IPR012677; IPR000504; IPR000061; U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) U2surp Sr140 Mus musculus (Mouse) TR40652_c2_g1_i3 Q9Y6N5 SQRD_HUMAN 1.00E-103 GO:0034641; GO:0005743; GO:0070221; GO:0070224; GO:0000098 "cellular nitrogen compound metabolic process; mitochondrial inner membrane; sulfide oxidation, using sulfide:quinone oxidoreductase; sulfide:quinone oxidoreductase activity; sulfur amino acid catabolic process" IPR023753; IPR015904; "Sulfide:quinone oxidoreductase, mitochondrial (EC 1.-.-.-)" SQRDL CGI-44 Homo sapiens (Human) TR40652_c2_g1_i5 Q54DK1 SQRD_DICDI 9.00E-46 GO:0005739; GO:0016491; GO:0042762 mitochondrion; oxidoreductase activity; regulation of sulfur metabolic process IPR023753; IPR015904; "Sulfide:quinone oxidoreductase, mitochondrial (EC 1.-.-.-)" sqrdl DDB_G0292250 Dictyostelium discoideum (Slime mold) TR40653_c2_g5_i1 P31409 VATB_DROME 0 GO:0005524; GO:0015991; GO:0046034; GO:0005903; GO:0005769; GO:0016820; GO:0048471; GO:0033181; GO:0007035; GO:0000221 "ATP binding; ATP hydrolysis coupled proton transport; ATP metabolic process; brush border; early endosome; hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances; perinuclear region of cytoplasm; plasma membrane proton-transporting V-type ATPase complex; vacuolar acidification; vacuolar proton-transporting V-type ATPase, V1 domain" IPR020003; IPR000793; IPR000194; IPR004100; IPR005723; IPR027417; IPR022879; V-type proton ATPase subunit B (V-ATPase subunit B) (V-ATPase 55 kDa subunit) (Vacuolar proton pump subunit B) Vha55 CG17369 Drosophila melanogaster (Fruit fly) TR40654_c0_g1_i1 O93274 FZD8_XENLA 2.00E-172 GO:0004930; GO:0042813; GO:0060070; GO:0016021; GO:0007275; GO:0005886; GO:0051091 Q6EHH9 G-protein coupled receptor activity; Wnt-activated receptor activity; canonical Wnt receptor signaling pathway; integral to membrane; multicellular organismal development; plasma membrane; positive regulation of sequence-specific DNA binding transcription factor activity IPR000539; IPR015526; IPR020067; IPR026547; IPR017981; Frizzled-8 (Fz-8) (Xfz8) fzd8 fz8 Xenopus laevis (African clawed frog) TR40654_c0_g1_i2 Q9I9M5 FZD1_XENLA 0 GO:0004930; GO:0016055; GO:0042813; GO:0016021; GO:0007275; GO:0005886 G-protein coupled receptor activity; Wnt receptor signaling pathway; Wnt-activated receptor activity; integral to membrane; multicellular organismal development; plasma membrane IPR000539; IPR015526; IPR020067; IPR026548; IPR017981; Frizzled-1 (Fz-1) (Xfz1) fzd1 fz1 Xenopus laevis (African clawed frog) TR40654_c0_g1_i3 Q61091 FZD8_MOUSE 2.00E-97 GO:0004930; GO:0005794; GO:0030165; GO:0033077; GO:0042813; GO:0007409; GO:0007420; GO:0060070; GO:0042995; GO:0005737; GO:0009790; GO:0008406; GO:0016021; GO:0000122; GO:0005886; GO:0043507; GO:0045944; GO:0001944 Q8BH60 G-protein coupled receptor activity; Golgi apparatus; PDZ domain binding; T cell differentiation in thymus; Wnt-activated receptor activity; axonogenesis; brain development; canonical Wnt receptor signaling pathway; cell projection; cytoplasm; embryo development; gonad development; integral to membrane; negative regulation of transcription from RNA polymerase II promoter; plasma membrane; positive regulation of JUN kinase activity; positive regulation of transcription from RNA polymerase II promoter; vasculature development IPR000539; IPR015526; IPR020067; IPR026547; IPR017981; Frizzled-8 (Fz-8) (mFz8) Fzd8 Mus musculus (Mouse) TR40654_c0_g1_i4 Q9IA05 FZD4_CHICK 2.00E-107 GO:0004930; GO:0030165; GO:0007223; GO:0042813; GO:0017147; GO:0007420; GO:0060070; GO:0042995; GO:0009986; GO:0005911; GO:0061301; GO:0005737; GO:0009790; GO:0035426; GO:0016021; GO:0031987; GO:0010812; GO:0005886; GO:0043507; GO:0051091; GO:0045893; GO:0042701; GO:0030947; GO:0061304; GO:0007605; GO:0034446; GO:0001570 "G-protein coupled receptor activity; PDZ domain binding; Wnt receptor signaling pathway, calcium modulating pathway; Wnt-activated receptor activity; Wnt-protein binding; brain development; canonical Wnt receptor signaling pathway; cell projection; cell surface; cell-cell junction; cerebellum vasculature morphogenesis; cytoplasm; embryo development; extracellular matrix-cell signaling; integral to membrane; locomotion involved in locomotory behavior; negative regulation of cell-substrate adhesion; plasma membrane; positive regulation of JUN kinase activity; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; progesterone secretion; regulation of vascular endothelial growth factor receptor signaling pathway; retinal blood vessel morphogenesis; sensory perception of sound; substrate adhesion-dependent cell spreading; vasculogenesis" IPR000539; IPR015526; IPR020067; IPR026551; IPR017981; Frizzled-4 (Fz-4) (cFz-4) FZD4 FZ4 Gallus gallus (Chicken) TR40654_c0_g1_i5 O57329 FZD7_CHICK 1.00E-160 GO:0004930; GO:0007199; GO:0030165; GO:0007223; GO:0042813; GO:0017147; GO:0045177; GO:0007409; GO:0007420; GO:0060070; GO:0005737; GO:0009790; GO:0030855; GO:0008406; GO:0016021; GO:0032589; GO:0001944 "G-protein coupled receptor activity; G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; PDZ domain binding; Wnt receptor signaling pathway, calcium modulating pathway; Wnt-activated receptor activity; Wnt-protein binding; apical part of cell; axonogenesis; brain development; canonical Wnt receptor signaling pathway; cytoplasm; embryo development; epithelial cell differentiation; gonad development; integral to membrane; neuron projection membrane; vasculature development" IPR000539; IPR015526; IPR020067; IPR026552; IPR017981; Frizzled-7 (Fz-7) (cFz-7) FZD7 FZ7 Gallus gallus (Chicken) TR40654_c0_g1_i6 P97401 SFRP3_MOUSE 4.00E-27 GO:0030165; GO:0016055; GO:0042813; GO:0017147; GO:0007420; GO:0090103; GO:0060029; GO:0005737; GO:0005615; GO:0008406; GO:0060056; GO:0090090; GO:0061037; GO:0010721; GO:0030308; GO:0008285; GO:0070367; GO:0014033; GO:0043065; GO:0045600; GO:0006357; GO:0061053; GO:0001944 PDZ domain binding; Wnt receptor signaling pathway; Wnt-activated receptor activity; Wnt-protein binding; brain development; cochlea morphogenesis; convergent extension involved in organogenesis; cytoplasm; extracellular space; gonad development; mammary gland involution; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of cartilage development; negative regulation of cell development; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of hepatocyte differentiation; neural crest cell differentiation; positive regulation of apoptotic process; positive regulation of fat cell differentiation; regulation of transcription from RNA polymerase II promoter; somite development; vasculature development IPR015526; IPR020067; IPR001134; IPR018933; IPR026556; IPR008993; Secreted frizzled-related protein 3 (sFRP-3) (Frezzled) (Fritz) (Frizzled-related protein 1) (FrzB-1) Frzb Fiz Fre Frzb1 Sfrp3 Mus musculus (Mouse) TR40657_c0_g1_i1 Q5F4B2 SWP70_CHICK 7.00E-06 GO:0003677; GO:0005737; GO:0030027; GO:0005634; GO:0005543; GO:0005886 DNA binding; cytoplasm; lamellipodium; nucleus; phospholipid binding; plasma membrane IPR011993; IPR001849; Switch-associated protein 70 (SWAP-70) SWAP70 RCJMB04_1e1 RCJMB04_8b3 Gallus gallus (Chicken) TR40657_c1_g1_i1 Q8RZB5 CML10_ORYSJ 2.00E-08 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Probable calcium-binding protein CML10 (Calmodulin-like protein 10) CML10 Os01g0949500 LOC_Os01g72100 B1147A04.18 Oryza sativa subsp. japonica (Rice) TR40657_c1_g1_i2 Q5ZD81 CML12_ORYSJ 7.00E-07 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Probable calcium-binding protein CML12 (Calmodulin-like protein 12) CML12 Os01g0604500 LOC_Os01g41990 P0681B11.28 Oryza sativa subsp. japonica (Rice) TR40657_c1_g1_i3 P04630 CALL_CAEEL 3.00E-08 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-like protein cal-1 cmd-1 C13C12.1 Caenorhabditis elegans TR40657_c1_g1_i4 P0C1G6 SWP70_BOVIN 2.00E-12 GO:0003677; GO:0005737; GO:0030027; GO:0005634; GO:0005543; GO:0005886 DNA binding; cytoplasm; lamellipodium; nucleus; phospholipid binding; plasma membrane IPR011993; IPR001849; Switch-associated protein 70 (SWAP-70) SWAP70 Bos taurus (Bovine) TR40657_c2_g1_i1 P16924 P4HA1_CHICK 2.00E-19 GO:0031418; GO:0005788; GO:0005506; GO:0016702; GO:0004656 "L-ascorbic acid binding; endoplasmic reticulum lumen; iron ion binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; procollagen-proline 4-dioxygenase activity" IPR005123; IPR006620; IPR013547; IPR013026; IPR011990; IPR019734; "Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)" P4HA1 P4HA Gallus gallus (Chicken) TR40658_c0_g1_i1 Q00546 TENR_CHICK 6.00E-46 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR013032; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin-R (TN-R) (Restrictin) TNR Gallus gallus (Chicken) TR40658_c0_g1_i2 P33573 FIBA2_PETMA 2.00E-20 GO:0005577; GO:0030168; GO:0051258; GO:0007165 fibrinogen complex; platelet activation; protein polymerization; signal transduction IPR014716; IPR014715; IPR002181; IPR012290; IPR020837; Fibrinogen alpha-2 chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha-2 chain] Petromyzon marinus (Sea lamprey) TR40658_c0_g1_i4 O00602 FCN1_HUMAN 3.00E-42 GO:0003823; GO:0005509; GO:0030246; GO:0005581; GO:0001867; GO:0005576; GO:0008228 Q2TS39 "antigen binding; calcium ion binding; carbohydrate binding; collagen; complement activation, lectin pathway; extracellular region; opsonization" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) FCN1 FCNM Homo sapiens (Human) TR40658_c0_g2_i2 Q2TNK5 ANGL4_PIG 2.00E-12 GO:0001525; GO:0030154; GO:0004857; GO:0005615; GO:0043066; GO:0051005; GO:0005578; GO:0070328 angiogenesis; cell differentiation; enzyme inhibitor activity; extracellular space; negative regulation of apoptotic process; negative regulation of lipoprotein lipase activity; proteinaceous extracellular matrix; triglyceride homeostasis IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-related protein 4 (Angiopoietin-like protein 4) ANGPTL4 PGAR Sus scrofa (Pig) TR40658_c0_g6_i1 P19477 FIBA_PARPA 8.00E-31 IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein A (FREP-A) Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) TR40658_c0_g7_i1 P55083 MFAP4_HUMAN 3.00E-28 GO:0007155; GO:0030198; GO:0001527 cell adhesion; extracellular matrix organization; microfibril IPR014716; IPR014715; IPR002181; Microfibril-associated glycoprotein 4 MFAP4 Homo sapiens (Human) TR40658_c0_g7_i2 Q95LU3 FBCD1_MACFA 2.00E-32 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR40658_c0_g7_i3 Q9Y264 ANGP4_HUMAN 7.00E-28 GO:0001525; GO:0007596; GO:0071456; GO:0005615; GO:0050900; GO:0016525; GO:0043066; GO:0043537; GO:0045766; GO:0043536; GO:0030971; GO:0030297 angiogenesis; blood coagulation; cellular response to hypoxia; extracellular space; leukocyte migration; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of blood vessel endothelial cell migration; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; receptor tyrosine kinase binding; transmembrane receptor protein tyrosine kinase activator activity IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3) ANGPT4 ANG3 ANG4 Homo sapiens (Human) TR40659_c2_g2_i10 Q8TF01 PNISR_HUMAN 2.00E-17 GO:0016607 nuclear speck "Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18)" PNISR C6orf111 SFRS18 SRRP130 HSPC261 HSPC306 Homo sapiens (Human) TR40659_c2_g2_i2 Q8TF01 PNISR_HUMAN 3.00E-15 GO:0016607 nuclear speck "Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18)" PNISR C6orf111 SFRS18 SRRP130 HSPC261 HSPC306 Homo sapiens (Human) TR40659_c2_g2_i6 Q8TF01 PNISR_HUMAN 2.00E-15 GO:0016607 nuclear speck "Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18)" PNISR C6orf111 SFRS18 SRRP130 HSPC261 HSPC306 Homo sapiens (Human) TR4066_c0_g1_i1 Q14896 MYPC3_HUMAN 1.00E-05 GO:0001671; GO:0014705; GO:0060048; GO:0007155; GO:0005829; GO:0046872; GO:0030049; GO:0017022; GO:0031034; GO:0002027; GO:0032971; GO:0006942; GO:0045214; GO:0005863; GO:0008307; GO:0031432; GO:0055010 Itself ATPase activator activity; C zone; cardiac muscle contraction; cell adhesion; cytosol; metal ion binding; muscle filament sliding; myosin binding; myosin filament assembly; regulation of heart rate; regulation of muscle filament sliding; regulation of striated muscle contraction; sarcomere organization; striated muscle myosin thick filament; structural constituent of muscle; titin binding; ventricular cardiac muscle tissue morphogenesis IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; "Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)" MYBPC3 Homo sapiens (Human) TR40660_c0_g1_i2 Q6P2B1 TNPO3_MOUSE 0 GO:0005737; GO:0005634; GO:0035048 cytoplasm; nucleus; splicing factor protein import into nucleus IPR011989; IPR016024; IPR013598; Transportin-3 Tnpo3 Mus musculus (Mouse) TR40661_c2_g1_i1 G5E8K5 ANK3_MOUSE 1.00E-56 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR40661_c2_g1_i3 Q9ULJ7 ANR50_HUMAN 9.00E-53 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) TR40661_c2_g1_i4 Q0P5G1 TONSL_BOVIN 7.00E-09 GO:0005662; GO:0035101; GO:0042555; GO:0005737; GO:0000724; GO:0042393; GO:0043596; GO:0031297 DNA replication factor A complex; FACT complex; MCM complex; cytoplasm; double-strand break repair via homologous recombination; histone binding; nuclear replication fork; replication fork processing IPR002110; IPR020683; IPR011990; IPR019734; Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2) TONSL IKBR NFKBIL2 Bos taurus (Bovine) TR40661_c2_g1_i7 G5E8K5 ANK3_MOUSE 1.00E-54 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR40665_c5_g5_i2 Q01097 NMDE2_MOUSE 3.00E-104 GO:0004972; GO:0017146; GO:0001662; GO:0048266; GO:0005262; GO:0030054; GO:0009986; GO:0050966; GO:0005234; GO:0001701; GO:0007612; GO:0007613; GO:0097481; GO:0045211; GO:0042734; GO:0060079; GO:0048168; GO:0045471; GO:0007423; GO:0001964; GO:0001967; GO:0008021; GO:0008270 Q9JI91; P17426; P11798; Q80YE7; Q62108 N-methyl-D-aspartate selective glutamate receptor activity; N-methyl-D-aspartate selective glutamate receptor complex; behavioral fear response; behavioral response to pain; calcium channel activity; cell junction; cell surface; detection of mechanical stimulus involved in sensory perception of pain; extracellular-glutamate-gated ion channel activity; in utero embryonic development; learning; memory; neuronal postsynaptic density; postsynaptic membrane; presynaptic membrane; regulation of excitatory postsynaptic membrane potential; regulation of neuronal synaptic plasticity; response to ethanol; sensory organ development; startle response; suckling behavior; synaptic vesicle; zinc ion binding IPR001828; IPR019594; IPR001320; IPR001508; IPR018884; IPR028082; IPR001638; "Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B)" Grin2b Mus musculus (Mouse) TR40665_c5_g5_i4 Q9C8E7 GLR33_ARATH 3.00E-17 GO:0004965; GO:0005262; GO:0019722; GO:0071230; GO:0005234; GO:0008066; GO:0009630; GO:0045087; GO:0016021; GO:0004970; GO:0035235; GO:0005886 G-protein coupled GABA receptor activity; calcium channel activity; calcium-mediated signaling; cellular response to amino acid stimulus; extracellular-glutamate-gated ion channel activity; glutamate receptor activity; gravitropism; innate immune response; integral to membrane; ionotropic glutamate receptor activity; ionotropic glutamate receptor signaling pathway; plasma membrane IPR001828; IPR002455; IPR001320; IPR017103; IPR028082; IPR001638; Glutamate receptor 3.3 (Ligand-gated ion channel 3.3) GLR3.3 At1g42540 T8D8.1 Arabidopsis thaliana (Mouse-ear cress) TR40665_c5_g5_i5 Q00959 NMDE1_RAT 2.00E-89 GO:0004972; GO:0017146; GO:0030054; GO:0071230; GO:0071359; GO:0071363; GO:0071396; GO:0071286; GO:0071287; GO:0071294; GO:0021987; GO:0043197; GO:0005234; GO:0016595; GO:0021766; GO:0007613; GO:0042165; GO:0010942; GO:2000463; GO:0014069; GO:0045211; GO:0042734; GO:0046982; GO:0051262; GO:0001508; GO:0048169; GO:0014075; GO:0051592; GO:0009743; GO:0042220; GO:0042493; GO:0045471; GO:0060992; GO:0009416; GO:0051597; GO:0051707; GO:0048511; GO:0021510; GO:0043195; GO:0022843; GO:0008270 P31016; P05480 N-methyl-D-aspartate selective glutamate receptor activity; N-methyl-D-aspartate selective glutamate receptor complex; cell junction; cellular response to amino acid stimulus; cellular response to dsRNA; cellular response to growth factor stimulus; cellular response to lipid; cellular response to magnesium ion; cellular response to manganese ion; cellular response to zinc ion; cerebral cortex development; dendritic spine; extracellular-glutamate-gated ion channel activity; glutamate binding; hippocampus development; memory; neurotransmitter binding; positive regulation of cell death; positive regulation of excitatory postsynaptic membrane potential; postsynaptic density; postsynaptic membrane; presynaptic membrane; protein heterodimerization activity; protein tetramerization; regulation of action potential; regulation of long-term neuronal synaptic plasticity; response to amine stimulus; response to calcium ion; response to carbohydrate stimulus; response to cocaine; response to drug; response to ethanol; response to fungicide; response to light stimulus; response to methylmercury; response to other organism; rhythmic process; spinal cord development; terminal bouton; voltage-gated cation channel activity; zinc ion binding IPR001828; IPR019594; IPR001320; IPR001508; IPR018884; IPR028082; IPR001638; "Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A)" Grin2a Rattus norvegicus (Rat) TR40666_c0_g1_i1 Q02446 SP4_HUMAN 2.00E-69 GO:0003677; GO:0046872; GO:0005634; GO:0006357; GO:0003700; GO:0003713; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Transcription factor Sp4 (SPR-1) SP4 Homo sapiens (Human) TR40667_c1_g1_i1 Q27295 EAT5_CAEEL 3.00E-08 GO:0005921; GO:0055077; GO:0016021; GO:0006811; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transport; plasma membrane IPR000990; Innexin eat-5 (Abnormal pharyngeal pumping eat-5) eat-5 F13G3.8 Caenorhabditis elegans TR40667_c1_g1_i3 Q19746 INX3_CAEEL 4.00E-17 GO:0005737; GO:0005921; GO:0055077; GO:0016021; GO:0006811; GO:0005886 cytoplasm; gap junction; gap junction hemi-channel activity; integral to membrane; ion transport; plasma membrane IPR000990; Innexin-3 (Protein opu-3) inx-3 opu-3 F22F4.2 Caenorhabditis elegans TR40667_c1_g1_i4 Q03412 UNC7_CAEEL 5.00E-13 GO:0005921; GO:0016264; GO:0055077; GO:0016021; GO:0034220; GO:0040011; GO:0032589; GO:0018991; GO:0043051; GO:0042221 gap junction; gap junction assembly; gap junction hemi-channel activity; integral to membrane; ion transmembrane transport; locomotion; neuron projection membrane; oviposition; regulation of pharyngeal pumping; response to chemical stimulus IPR000990; Innexin unc-7 (Uncoordinated protein 7) unc-7 unc-12 unc-124 R07D5.1 Caenorhabditis elegans TR40667_c1_g1_i5 Q22549 INX10_CAEEL 1.00E-15 GO:0005921; GO:0055077; GO:0016021; GO:0006811; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transport; plasma membrane IPR000990; Innexin-10 (Protein opu-10) inx-10 opu-10 T18H9.5 Caenorhabditis elegans TR40667_c1_g1_i7 O61715 INX19_CAEEL 4.00E-11 GO:0019855; GO:0030154; GO:0035545; GO:0005921; GO:0055077; GO:0051390; GO:0016021; GO:0010496; GO:0006811; GO:2001258; GO:0032809; GO:0004860 calcium channel inhibitor activity; cell differentiation; determination of left/right asymmetry in nervous system; gap junction; gap junction hemi-channel activity; inactivation of MAPKKK activity; integral to membrane; intercellular transport; ion transport; negative regulation of cation channel activity; neuronal cell body membrane; protein kinase inhibitor activity IPR000990; Innexin-19 (Neuronal symmetry protein 5) (Protein opu-19) inx-19 nsy-5 opu-19 T16H5.1 Caenorhabditis elegans TR40667_c1_g1_i8 Q19746 INX3_CAEEL 6.00E-18 GO:0005737; GO:0005921; GO:0055077; GO:0016021; GO:0006811; GO:0005886 cytoplasm; gap junction; gap junction hemi-channel activity; integral to membrane; ion transport; plasma membrane IPR000990; Innexin-3 (Protein opu-3) inx-3 opu-3 F22F4.2 Caenorhabditis elegans TR40669_c1_g1_i2 O14255 GCS1_SCHPO 3.00E-84 GO:0005789; GO:0009272; GO:0016021; GO:0004573; GO:0009311; GO:0006487 endoplasmic reticulum membrane; fungal-type cell wall biogenesis; integral to membrane; mannosyl-oligosaccharide glucosidase activity; oligosaccharide metabolic process; protein N-linked glycosylation IPR008928; IPR004888; Probable mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I) SPAC6G10.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40669_c1_g1_i3 Q80UM7 MOGS_MOUSE 0 GO:0005789; GO:0016021; GO:0004573; GO:0009311 endoplasmic reticulum membrane; integral to membrane; mannosyl-oligosaccharide glucosidase activity; oligosaccharide metabolic process IPR008928; IPR004888; Glycan metabolism; N-glycan degradation. Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Glucosidase 1) (Glycoprotein-processing glucosidase I) Mogs Gcs1 Mus musculus (Mouse) TR40669_c1_g1_i4 Q13724 MOGS_HUMAN 6.00E-18 GO:0005789; GO:0015926; GO:0016021; GO:0004573; GO:0009311; GO:0043687; GO:0018279; GO:0006457 endoplasmic reticulum membrane; glucosidase activity; integral to membrane; mannosyl-oligosaccharide glucosidase activity; oligosaccharide metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine; protein folding IPR008928; IPR004888; Glycan metabolism; N-glycan degradation. Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I) MOGS GCS1 Homo sapiens (Human) TR40670_c0_g1_i1 A0JMI9 RRF2M_DANRE 0 GO:0005525; GO:0003924; GO:0032543; GO:0005739; GO:0032790 GTP binding; GTPase activity; mitochondrial translation; mitochondrion; ribosome disassembly IPR000795; IPR009022; IPR000640; IPR027417; IPR020568; IPR014721; IPR005225; IPR009000; IPR005517; IPR004161; "Ribosome-releasing factor 2, mitochondrial (RRF2mt) (Elongation factor G 2, mitochondrial) (EF-G2mt) (mEF-G 2)" gfm2 efg2 si:dkey-35i22.3 zgc:153835 Danio rerio (Zebrafish) (Brachydanio rerio) TR40672_c0_g1_i2 Q5RDN9 YPEL2_PONAB 3.00E-26 GO:0005730 nucleolus IPR004910; Protein yippee-like 2 YPEL2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40672_c0_g1_i4 Q5RDU7 YPEL5_PONAB 6.00E-65 IPR004910; Protein yippee-like 5 YPEL5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40672_c0_g1_i6 Q5RDU7 YPEL5_PONAB 5.00E-65 IPR004910; Protein yippee-like 5 YPEL5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40677_c1_g1_i2 Q9ET47 ESPN_MOUSE 4.00E-62 GO:0017124; GO:0051015; GO:0051639; GO:0005903; GO:0030054; GO:0005737; GO:0043197; GO:0031941; GO:0007626; GO:0051494; GO:0030046; GO:0051491; GO:0007605; GO:0032420; GO:0032426 SH3 domain binding; actin filament binding; actin filament network formation; brush border; cell junction; cytoplasm; dendritic spine; filamentous actin; locomotory behavior; negative regulation of cytoskeleton organization; parallel actin filament bundle assembly; positive regulation of filopodium assembly; sensory perception of sound; stereocilium; stereocilium bundle tip IPR002110; IPR020683; IPR003124; Espin (Ectoplasmic specialization protein) Espn Mus musculus (Mouse) TR40678_c1_g1_i1 Q8CFY5 COX10_MOUSE 8.00E-106 GO:0009060; GO:0017004; GO:0004129; GO:0048034; GO:0006784; GO:0016021; GO:0000266; GO:0031966; GO:0005739; GO:0008495; GO:0008535 aerobic respiration; cytochrome complex assembly; cytochrome-c oxidase activity; heme O biosynthetic process; heme a biosynthetic process; integral to membrane; mitochondrial fission; mitochondrial membrane; mitochondrion; protoheme IX farnesyltransferase activity; respiratory chain complex IV assembly IPR006369; IPR016315; IPR000537; "Protoheme IX farnesyltransferase, mitochondrial (EC 2.5.1.-) (Heme O synthase)" Cox10 Mus musculus (Mouse) TR40678_c1_g1_i3 Q8CFY5 COX10_MOUSE 8.00E-106 GO:0009060; GO:0017004; GO:0004129; GO:0048034; GO:0006784; GO:0016021; GO:0000266; GO:0031966; GO:0005739; GO:0008495; GO:0008535 aerobic respiration; cytochrome complex assembly; cytochrome-c oxidase activity; heme O biosynthetic process; heme a biosynthetic process; integral to membrane; mitochondrial fission; mitochondrial membrane; mitochondrion; protoheme IX farnesyltransferase activity; respiratory chain complex IV assembly IPR006369; IPR016315; IPR000537; "Protoheme IX farnesyltransferase, mitochondrial (EC 2.5.1.-) (Heme O synthase)" Cox10 Mus musculus (Mouse) TR4068_c0_g2_i1 Q90YQ6 RS17_ICTPU 8.00E-73 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001210; IPR018273; 40S ribosomal protein S17 rps17 Ictalurus punctatus (Channel catfish) (Silurus punctatus) TR40681_c3_g1_i1 P04323 POL3_DROME 9.00E-44 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR40681_c3_g2_i1 P10394 POL4_DROME 8.00E-48 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR40683_c0_g3_i1 Q09289 ADRM1_CAEEL 2.00E-30 GO:0005737; GO:0061133; GO:0005634; GO:0043248; GO:0000502 cytoplasm; endopeptidase activator activity; nucleus; proteasome assembly; proteasome complex IPR006773; Proteasomal ubiquitin receptor ADRM1 homolog C56G2.7 Caenorhabditis elegans TR40683_c0_g3_i3 Q6P877 ADRM1_XENTR 8.00E-62 GO:0005737; GO:0061133; GO:0005634; GO:0043248; GO:0000502 cytoplasm; endopeptidase activator activity; nucleus; proteasome assembly; proteasome complex IPR006773; Proteasomal ubiquitin receptor ADRM1 adrm1 TEgg050m05.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40684_c1_g1_i2 Q6DDW4 CPSF6_XENLA 4.00E-33 GO:0003729; GO:0005849; GO:0006378; GO:0000166 mRNA binding; mRNA cleavage factor complex; mRNA polyadenylation; nucleotide binding IPR012677; IPR000504; Cleavage and polyadenylation specificity factor subunit 6 cpsf6 Xenopus laevis (African clawed frog) TR40686_c0_g1_i1 O00534 VMA5A_HUMAN 4.00E-113 GO:0005634 nucleus IPR013694; IPR002035; von Willebrand factor A domain-containing protein 5A (Breast cancer suppressor candidate 1) (BCSC-1) (Loss of heterozygosity 11 chromosomal region 2 gene A protein) VWA5A BCSC1 LOH11CR2A Homo sapiens (Human) TR40686_c0_g1_i10 Q99KC8 VMA5A_MOUSE 7.00E-71 IPR013694; IPR002035; von Willebrand factor A domain-containing protein 5A (Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog) Vwa5a Loh11cr2a Mus musculus (Mouse) TR40686_c0_g1_i2 Q99KC8 VMA5A_MOUSE 1.00E-109 IPR013694; IPR002035; von Willebrand factor A domain-containing protein 5A (Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog) Vwa5a Loh11cr2a Mus musculus (Mouse) TR40686_c0_g1_i3 A9Z1V5 VW5B1_MOUSE 2.00E-51 GO:0005576 extracellular region IPR013694; IPR002035; von Willebrand factor A domain-containing protein 5B1 Vwa5b1 Mus musculus (Mouse) TR40686_c0_g1_i4 O00534 VMA5A_HUMAN 7.00E-117 GO:0005634 nucleus IPR013694; IPR002035; von Willebrand factor A domain-containing protein 5A (Breast cancer suppressor candidate 1) (BCSC-1) (Loss of heterozygosity 11 chromosomal region 2 gene A protein) VWA5A BCSC1 LOH11CR2A Homo sapiens (Human) TR40686_c0_g1_i6 Q54DV3 Y2016_DICDI 3.00E-39 IPR013694; IPR002035; von Willebrand factor A domain-containing protein DDB_G0292016 DDB_G0292016 Dictyostelium discoideum (Slime mold) TR40686_c0_g1_i7 O00534 VMA5A_HUMAN 6.00E-114 GO:0005634 nucleus IPR013694; IPR002035; von Willebrand factor A domain-containing protein 5A (Breast cancer suppressor candidate 1) (BCSC-1) (Loss of heterozygosity 11 chromosomal region 2 gene A protein) VWA5A BCSC1 LOH11CR2A Homo sapiens (Human) TR40688_c2_g1_i1 Q3UES3 TNKS2_MOUSE 1.00E-12 GO:0000139; GO:0003950; GO:0016055; GO:0000781; GO:0046872; GO:0035264; GO:0005635; GO:0000242; GO:0048471; GO:0090263; GO:0070213; GO:0070198; GO:0000209; GO:0040014; GO:0000723 "Golgi membrane; NAD+ ADP-ribosyltransferase activity; Wnt receptor signaling pathway; chromosome, telomeric region; metal ion binding; multicellular organism growth; nuclear envelope; pericentriolar material; perinuclear region of cytoplasm; positive regulation of canonical Wnt receptor signaling pathway; protein auto-ADP-ribosylation; protein localization to chromosome, telomeric region; protein polyubiquitination; regulation of multicellular organism growth; telomere maintenance" IPR002110; IPR020683; IPR012317; IPR001660; IPR013761; IPR011510; Tankyrase-2 (TANK2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) Tnks2 Tank2 Mus musculus (Mouse) TR40689_c0_g1_i16 P46090 GPR1_RAT 8.00E-06 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR000276; IPR017452; IPR002275; G-protein coupled receptor 1 Gpr1 Rattus norvegicus (Rat) TR40689_c0_g1_i6 P30551 CCKAR_RAT 5.00E-07 GO:0031532; GO:0032870; GO:0004951; GO:0007204; GO:0005783; GO:0005768; GO:0001696; GO:0030073; GO:0016021; GO:0005764; GO:0031100; GO:0031016; GO:0030157; GO:0005886; GO:0090274; GO:0002023; GO:0051924; GO:0043266; GO:0051384; GO:0009408; GO:0032496; GO:0007584; GO:0009314; GO:0042594; GO:0001659; GO:0043195 actin cytoskeleton reorganization; cellular response to hormone stimulus; cholecystokinin receptor activity; elevation of cytosolic calcium ion concentration; endoplasmic reticulum; endosome; gastric acid secretion; insulin secretion; integral to membrane; lysosome; organ regeneration; pancreas development; pancreatic juice secretion; plasma membrane; positive regulation of somatostatin secretion; reduction of food intake in response to dietary excess; regulation of calcium ion transport; regulation of potassium ion transport; response to glucocorticoid stimulus; response to heat; response to lipopolysaccharide; response to nutrient; response to radiation; response to starvation; temperature homeostasis; terminal bouton IPR009126; IPR000596; IPR015276; IPR000276; IPR017452; Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) Cckar Rattus norvegicus (Rat) TR4069_c1_g1_i1 Q9VCA8 ANKHM_DROME 3.00E-11 GO:0003723; GO:0019730; GO:0051298; GO:0001751; GO:0005811; GO:0043066; GO:0046427; GO:0007169 RNA binding; antimicrobial humoral response; centrosome duplication; compound eye photoreceptor cell differentiation; lipid particle; negative regulation of apoptotic process; positive regulation of JAK-STAT cascade; transmembrane receptor protein tyrosine kinase signaling pathway IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) TR40690_c1_g1_i1 Q2KIS9 TSN8_BOVIN 5.00E-09 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-8 (Tspan-8) TSPAN8 Bos taurus (Bovine) TR40690_c1_g1_i2 Q7YQL0 TSN7_PANTR 4.00E-50 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-7 (Tspan-7) (Transmembrane 4 superfamily member 2) (CD antigen CD231) TSPAN7 TM4SF2 Pan troglodytes (Chimpanzee) TR40690_c1_g1_i3 P28648 CD63_RAT 1.00E-31 GO:0030855; GO:0016021; GO:0005765; GO:0005764; GO:0010633; GO:0005886; GO:0045785; GO:0045807; GO:0043234; GO:0032403; GO:0030658 Q03348; Q9WUD9 epithelial cell differentiation; integral to membrane; lysosomal membrane; lysosome; negative regulation of epithelial cell migration; plasma membrane; positive regulation of cell adhesion; positive regulation of endocytosis; protein complex; protein complex binding; transport vesicle membrane IPR000301; IPR018499; IPR018503; IPR008952; CD63 antigen (Mast cell antigen AD1) (CD antigen CD63) Cd63 Rattus norvegicus (Rat) TR40691_c2_g2_i1 Q9NQX5 NPDC1_HUMAN 5.00E-20 GO:0016021 integral to membrane IPR009635; Neural proliferation differentiation and control protein 1 (NPDC-1) NPDC1 Homo sapiens (Human) TR40693_c0_g1_i1 Q8NFW1 COMA1_HUMAN 2.00E-28 GO:0005581; GO:0005788; GO:0030198; GO:0005576 collagen; endoplasmic reticulum lumen; extracellular matrix organization; extracellular region IPR008160; IPR008985; IPR001791; IPR002035; Collagen alpha-1(XXII) chain COL22A1 Homo sapiens (Human) TR40693_c0_g1_i3 Q99715 COCA1_HUMAN 5.00E-17 GO:0007155; GO:0030574; GO:0030199; GO:0005595; GO:0005788; GO:0022617; GO:0030020; GO:0005615; GO:0070062; GO:0001501 cell adhesion; collagen catabolic process; collagen fibril organization; collagen type XII; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular matrix structural constituent conferring tensile strength; extracellular space; extracellular vesicular exosome; skeletal system development IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) TR40696_c3_g1_i2 Q9W141 ATPK_DROME 9.00E-18 GO:0006754; GO:0046331; GO:0005811; GO:0031966; GO:0015992; GO:0045263 Q9VTU0 "ATP biosynthetic process; lateral inhibition; lipid particle; mitochondrial membrane; proton transport; proton-transporting ATP synthase complex, coupling factor F(o)" IPR019344; "Putative ATP synthase subunit f, mitochondrial" CG4692 Drosophila melanogaster (Fruit fly) TR40696_c4_g1_i1 P94428 GABD_BACSU 5.00E-97 GO:0009450; GO:0009013 gamma-aminobutyric acid catabolic process; succinate-semialdehyde dehydrogenase [NAD(P)+] activity IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR010102; Amino-acid degradation; 4-aminobutanoate degradation. Succinate-semialdehyde dehydrogenase [NADP(+)] (SSDH) (EC 1.2.1.79) gabD ycnH BSU03910 Bacillus subtilis (strain 168) TR40696_c4_g1_i2 Q63639 AL1A2_RAT 0 GO:0004028; GO:0042904; GO:0009952; GO:0001568; GO:0048738; GO:0071300; GO:0005829; GO:0009855; GO:0031076; GO:0048566; GO:0035115; GO:0060324; GO:0003007; GO:0030902; GO:0001822; GO:0001889; GO:0030324; GO:0007494; GO:0016331; GO:0008285; GO:0014032; GO:0021915; GO:0030182; GO:0005634; GO:0031016; GO:0048471; GO:0021983; GO:0043065; GO:0008284; GO:0010628; GO:0009954; GO:0001936; GO:0034097; GO:0032355; GO:0033189; GO:0016918; GO:0001758; GO:0042574; GO:0002138; GO:0048384; GO:0042572; GO:0035799 3-chloroallyl aldehyde dehydrogenase activity; 9-cis-retinoic acid biosynthetic process; anterior/posterior pattern specification; blood vessel development; cardiac muscle tissue development; cellular response to retinoic acid; cytosol; determination of bilateral symmetry; embryonic camera-type eye development; embryonic digestive tract development; embryonic forelimb morphogenesis; face development; heart morphogenesis; hindbrain development; kidney development; liver development; lung development; midgut development; morphogenesis of embryonic epithelium; negative regulation of cell proliferation; neural crest cell development; neural tube development; neuron differentiation; nucleus; pancreas development; perinuclear region of cytoplasm; pituitary gland development; positive regulation of apoptotic process; positive regulation of cell proliferation; positive regulation of gene expression; proximal/distal pattern formation; regulation of endothelial cell proliferation; response to cytokine stimulus; response to estradiol stimulus; response to vitamin A; retinal binding; retinal dehydrogenase activity; retinal metabolic process; retinoic acid biosynthetic process; retinoic acid receptor signaling pathway; retinol metabolic process; ureter maturation IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Cofactor metabolism; retinol metabolism. Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II)) Aldh1a2 Raldh2 Rattus norvegicus (Rat) TR40696_c4_g1_i4 P27463 AL1A1_CHICK 5.00E-32 GO:0005737; GO:0001758; GO:0042572 cytoplasm; retinal dehydrogenase activity; retinol metabolic process IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Cofactor metabolism; retinol metabolism. "Retinal dehydrogenase 1 (RALDH 1) (RalDH1) (EC 1.2.1.36) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic)" ALDH1A1 Gallus gallus (Chicken) TR40697_c2_g2_i1 Q9BZJ0 CRNL1_HUMAN 0 GO:0003723; GO:0071013; GO:0005737; GO:0016607; GO:0000245 Q8WUD4 RNA binding; catalytic step 2 spliceosome; cytoplasm; nuclear speck; spliceosomal complex assembly IPR003107; IPR013026; IPR011990; Crooked neck-like protein 1 (Crooked neck homolog) (hCrn) CRNKL1 CRN CGI-201 MSTP021 Homo sapiens (Human) TR40698_c0_g1_i1 Q4QQM4 P5I11_MOUSE 3.00E-34 GO:0016021 integral to membrane IPR028266; Tumor protein p53-inducible protein 11 (Transformation related protein 53 inducible protein 11) (p53-induced gene 11 protein) Trp53i11 Pig11 Tp53i11 Mus musculus (Mouse) TR40698_c0_g1_i14 Q4QQM4 P5I11_MOUSE 7.00E-38 GO:0016021 integral to membrane IPR028266; Tumor protein p53-inducible protein 11 (Transformation related protein 53 inducible protein 11) (p53-induced gene 11 protein) Trp53i11 Pig11 Tp53i11 Mus musculus (Mouse) TR40698_c0_g1_i18 Q4QQM4 P5I11_MOUSE 3.00E-34 GO:0016021 integral to membrane IPR028266; Tumor protein p53-inducible protein 11 (Transformation related protein 53 inducible protein 11) (p53-induced gene 11 protein) Trp53i11 Pig11 Tp53i11 Mus musculus (Mouse) TR40698_c0_g1_i4 Q4QQM4 P5I11_MOUSE 2.00E-34 GO:0016021 integral to membrane IPR028266; Tumor protein p53-inducible protein 11 (Transformation related protein 53 inducible protein 11) (p53-induced gene 11 protein) Trp53i11 Pig11 Tp53i11 Mus musculus (Mouse) TR40698_c0_g1_i9 Q4QQM4 P5I11_MOUSE 2.00E-34 GO:0016021 integral to membrane IPR028266; Tumor protein p53-inducible protein 11 (Transformation related protein 53 inducible protein 11) (p53-induced gene 11 protein) Trp53i11 Pig11 Tp53i11 Mus musculus (Mouse) TR40699_c1_g2_i1 Q28F39 CC134_XENTR 4.00E-35 GO:0005576 extracellular region IPR026321; Coiled-coil domain-containing protein 134 ccdc134 TGas125o12.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40704_c0_g2_i1 Q8K2V1 PP4R1_MOUSE 3.00E-114 IPR011989; IPR016024; IPR000357; IPR021133; Serine/threonine-protein phosphatase 4 regulatory subunit 1 Ppp4r1 Mus musculus (Mouse) TR40704_c0_g2_i3 Q8K2V1 PP4R1_MOUSE 8.00E-114 IPR011989; IPR016024; IPR000357; IPR021133; Serine/threonine-protein phosphatase 4 regulatory subunit 1 Ppp4r1 Mus musculus (Mouse) TR40704_c0_g3_i1 Q9P1A2 PP4RL_HUMAN 2.00E-38 IPR011989; IPR016024; IPR021133; Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like PPP4R1L C20orf192 PRO1085 Homo sapiens (Human) TR40705_c2_g1_i1 Q15582 BGH3_HUMAN 2.00E-74 GO:0001525; GO:0007155; GO:0008283; GO:0050840; GO:0030198; GO:0005615; GO:0070062; GO:0005178; GO:0007162; GO:0005886; GO:0005578; GO:0050896; GO:0007601 angiogenesis; cell adhesion; cell proliferation; extracellular matrix binding; extracellular matrix organization; extracellular space; extracellular vesicular exosome; integrin binding; negative regulation of cell adhesion; plasma membrane; proteinaceous extracellular matrix; response to stimulus; visual perception IPR011489; IPR000782; IPR016666; Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) (Kerato-epithelin) (RGD-containing collagen-associated protein) (RGD-CAP) TGFBI BIGH3 Homo sapiens (Human) TR40705_c2_g1_i2 Q8CFM6 STAB2_RAT 3.00E-07 GO:0007155; GO:0005737; GO:0006897; GO:0009897; GO:0005540; GO:0016021 cell adhesion; cytoplasm; endocytosis; external side of plasma membrane; hyaluronic acid binding; integral to membrane IPR016186; IPR016187; IPR000742; IPR013032; IPR024731; IPR002049; IPR000782; IPR023413; IPR009030; IPR000538; "Stabilin-2 (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2) (FEEL-2) (Hyaluronan receptor for endocytosis) [Cleaved into: 175 kDa stabilin-2 (175 kDa hyaluronan receptor for endocytosis)] (Fragment)" Stab2 Feel2 Hare Rattus norvegicus (Rat) TR40705_c2_g1_i5 P10675 FAS1_SCHAM 1.00E-14 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR000782; Fasciclin-1 (Fasciclin I) (FAS I) (FCN) FAS1 Schistocerca americana (American grasshopper) TR40706_c0_g2_i1 Q99K23 UFSP2_MOUSE 4.00E-65 GO:0005783; GO:0005634; GO:0006508; GO:0019783; GO:0016790 endoplasmic reticulum; nucleus; proteolysis; small conjugating protein-specific protease activity; thiolester hydrolase activity IPR012462; Ufm1-specific protease 2 (UfSP2) (EC 3.4.22.-) Ufsp2 Mus musculus (Mouse) TR40706_c0_g2_i2 Q99K23 UFSP2_MOUSE 8.00E-67 GO:0005783; GO:0005634; GO:0006508; GO:0019783; GO:0016790 endoplasmic reticulum; nucleus; proteolysis; small conjugating protein-specific protease activity; thiolester hydrolase activity IPR012462; Ufm1-specific protease 2 (UfSP2) (EC 3.4.22.-) Ufsp2 Mus musculus (Mouse) TR40706_c0_g2_i3 Q3B8N0 UFSP2_XENLA 2.00E-65 GO:0005783; GO:0005634; GO:0006508; GO:0019783 endoplasmic reticulum; nucleus; proteolysis; small conjugating protein-specific protease activity IPR012462; Ufm1-specific protease 2 (UfSP2) (EC 3.4.22.-) ufsp2 Xenopus laevis (African clawed frog) TR40707_c1_g1_i1 Q9Y5Z9 UBIA1_HUMAN 2.00E-35 GO:0016209; GO:0005783; GO:0005789; GO:0030173; GO:0009234; GO:0031966; GO:0005634; GO:0004659; GO:0006744; GO:0042371 P04035; P35610; P35610-1 antioxidant activity; endoplasmic reticulum; endoplasmic reticulum membrane; integral to Golgi membrane; menaquinone biosynthetic process; mitochondrial membrane; nucleus; prenyltransferase activity; ubiquinone biosynthetic process; vitamin K biosynthetic process IPR000537; IPR026046; Cofactor biosynthesis; menaquinone biosynthesis. Cofactor biosynthesis; ubiquinone biosynthesis. UbiA prenyltransferase domain-containing protein 1 (EC 2.5.1.-) (Transitional epithelial response protein 1) UBIAD1 TERE1 Homo sapiens (Human) TR40707_c4_g1_i1 Q5KR61 PIGV_RAT 5.00E-90 GO:0006506; GO:0005789; GO:0016021; GO:0097502; GO:0000030 GPI anchor biosynthetic process; endoplasmic reticulum membrane; integral to membrane; mannosylation; mannosyltransferase activity IPR007315; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. GPI mannosyltransferase 2 (EC 2.4.1.-) (GPI mannosyltransferase II) (GPI-MT-II) (Phosphatidylinositol-glycan biosynthesis class V protein) (PIG-V) Pigv Rattus norvegicus (Rat) TR40707_c4_g1_i2 Q09712 GPI18_SCHPO 1.00E-20 GO:0006506; GO:0004584; GO:0030176 GPI anchor biosynthetic process; dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity; integral to endoplasmic reticulum membrane IPR007315; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. GPI mannosyltransferase 2 (EC 2.4.1.-) (GPI mannosyltransferase II) (GPI-MT-II) (Glycosylphosphatidylinositol-anchor biosynthesis protein 18) gpi18 SPAC18B11.05 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40707_c5_g1_i1 Q5ZKS8 UBIA1_CHICK 2.00E-63 GO:0016209; GO:0072358; GO:0005783; GO:0005789; GO:0001885; GO:0030173; GO:0009234; GO:0005739; GO:0004659; GO:0006744; GO:0042371 antioxidant activity; cardiovascular system development; endoplasmic reticulum; endoplasmic reticulum membrane; endothelial cell development; integral to Golgi membrane; menaquinone biosynthetic process; mitochondrion; prenyltransferase activity; ubiquinone biosynthetic process; vitamin K biosynthetic process IPR000537; IPR026046; Cofactor biosynthesis; menaquinone biosynthesis. Cofactor biosynthesis; ubiquinone biosynthesis. UbiA prenyltransferase domain-containing protein 1 (EC 2.5.1.-) UBIAD1 RCJMB04_9f15 Gallus gallus (Chicken) TR40707_c5_g2_i1 Q8BID8 FXL14_MOUSE 0 GO:0005737; GO:0042787; GO:0004842 cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR001810; IPR013101; F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14) Fbxl14 Fbl14 Ppa Mus musculus (Mouse) TR40709_c1_g2_i1 Q2W0P2 RLME_MAGSA 6.00E-27 GO:0005737; GO:0008650 cytoplasm; rRNA (uridine-2'-O-)-methyltransferase activity IPR015507; IPR002877; Ribosomal RNA large subunit methyltransferase E (EC 2.1.1.166) (23S rRNA Um2552 methyltransferase) (rRNA (uridine-2'-O-)-methyltransferase) rlmE ftsJ rrmJ amb3779 Magnetospirillum magneticum (strain AMB-1 / ATCC 700264) TR40709_c1_g2_i2 Q9VEP1 RMJ1A_DROME 2.00E-100 GO:0001510; GO:0005737; GO:0008168; GO:0008033 RNA methylation; cytoplasm; methyltransferase activity; tRNA processing IPR015507; IPR002877; Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase 1 (EC 2.1.1.205) (2'-O-ribose RNA methyltransferase TRM7 homolog 1) CG5220 Drosophila melanogaster (Fruit fly) TR40709_c1_g2_i3 Q9UET6 RRMJ1_HUMAN 6.00E-137 GO:0001510; GO:0005737; GO:0008168; GO:0008033 RNA methylation; cytoplasm; methyltransferase activity; tRNA processing IPR015507; IPR002877; Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (EC 2.1.1.205) (2'-O-ribose RNA methyltransferase TRM7 homolog) (Protein ftsJ homolog 1) FTSJ1 JM23 Homo sapiens (Human) TR40709_c1_g2_i4 P53123 MRM2_YEAST 6.00E-11 GO:0005739; GO:0008650 mitochondrion; rRNA (uridine-2'-O-)-methyltransferase activity IPR015507; IPR002877; "Ribosomal RNA methyltransferase MRM2, mitochondrial (EC 2.1.1.168) (rRNA (uridine-2'-O-)-methyltransferase)" MRM2 YGL136C G2830 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40710_c1_g1_i1 Q6DGL7 TM147_DANRE 9.00E-81 GO:0016021 integral to membrane IPR019164; Transmembrane protein 147 tmem147 zgc:92863 Danio rerio (Zebrafish) (Brachydanio rerio) TR40710_c1_g1_i3 Q6DGL7 TM147_DANRE 1.00E-81 GO:0016021 integral to membrane IPR019164; Transmembrane protein 147 tmem147 zgc:92863 Danio rerio (Zebrafish) (Brachydanio rerio) TR40711_c2_g1_i2 P33573 FIBA2_PETMA 1.00E-12 GO:0005577; GO:0030168; GO:0051258; GO:0007165 fibrinogen complex; platelet activation; protein polymerization; signal transduction IPR014716; IPR014715; IPR002181; IPR012290; IPR020837; Fibrinogen alpha-2 chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha-2 chain] Petromyzon marinus (Sea lamprey) TR40711_c2_g1_i5 Q24K15 ANGP4_BOVIN 1.00E-27 GO:0001525; GO:0005576 angiogenesis; extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) TR40711_c2_g3_i1 A0A8J8 ANGP2_CANFA 5.00E-21 GO:0048014; GO:0001525; GO:0030154; GO:0005615; GO:0046872; GO:0016525; GO:0043537; GO:0010812; GO:0050928 Tie signaling pathway; angiogenesis; cell differentiation; extracellular space; metal ion binding; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of cell-substrate adhesion; negative regulation of positive chemotaxis IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-2 (ANG-2) ANGPT2 Canis familiaris (Dog) (Canis lupus familiaris) TR40711_c2_g5_i3 Q00546 TENR_CHICK 2.00E-33 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR013032; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin-R (TN-R) (Restrictin) TNR Gallus gallus (Chicken) TR40711_c2_g6_i2 P19477 FIBA_PARPA 1.00E-20 IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein A (FREP-A) Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) TR40713_c2_g1_i1 Q4R7W3 RGPS2_MACFA 1.00E-129 GO:0005737; GO:0005085; GO:0005543; GO:0005886; GO:0007264 cytoplasm; guanyl-nucleotide exchange factor activity; phospholipid binding; plasma membrane; small GTPase mediated signal transduction IPR011993; IPR001849; IPR008937; IPR023578; IPR001895; Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) RALGPS2 QtsA-14234 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR40713_c2_g1_i2 Q5ZJK0 RGPS1_CHICK 2.00E-130 GO:0005737; GO:0005085; GO:0005543; GO:0005886; GO:0007264 cytoplasm; guanyl-nucleotide exchange factor activity; phospholipid binding; plasma membrane; small GTPase mediated signal transduction IPR011993; IPR001849; IPR008937; IPR023578; IPR001895; Ras-specific guanine nucleotide-releasing factor RalGPS1 (Ral GEF with PH domain and SH3-binding motif 1) (RalA exchange factor RalGPS1) RALGPS1 RCJMB04_17i24 Gallus gallus (Chicken) TR40713_c2_g2_i2 Q5EAR5 TRPT1_DANRE 1.00E-43 GO:0000215; GO:0006388 "tRNA 2'-phosphotransferase activity; tRNA splicing, via endonucleolytic cleavage and ligation" IPR002745; tRNA 2'-phosphotransferase 1 (EC 2.7.1.160) trpt1 zgc:113138 Danio rerio (Zebrafish) (Brachydanio rerio) TR40714_c0_g4_i1 B1H116 UCK2_XENTR 3.00E-103 GO:0005524; GO:0044211; GO:0044206; GO:0016773; GO:0004849 "ATP binding; CTP salvage; UMP salvage; phosphotransferase activity, alcohol group as acceptor; uridine kinase activity" IPR027417; IPR006083; IPR000764; Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Uridine monophosphokinase 2) uck2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40715_c0_g1_i1 Q99MN1 SYK_MOUSE 0 GO:0005524; GO:0004824; GO:0006430; GO:0046872; GO:0005739; GO:0003676 ATP binding; lysine-tRNA ligase activity; lysyl-tRNA aminoacylation; metal ion binding; mitochondrion; nucleic acid binding IPR004364; IPR018150; IPR006195; IPR002313; IPR018149; IPR012340; IPR004365; Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) Kars Mus musculus (Mouse) TR40715_c0_g1_i10 Q99MN1 SYK_MOUSE 0 GO:0005524; GO:0004824; GO:0006430; GO:0046872; GO:0005739; GO:0003676 ATP binding; lysine-tRNA ligase activity; lysyl-tRNA aminoacylation; metal ion binding; mitochondrion; nucleic acid binding IPR004364; IPR018150; IPR006195; IPR002313; IPR018149; IPR012340; IPR004365; Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) Kars Mus musculus (Mouse) TR40715_c0_g1_i7 P15180 SYKC_YEAST 0 GO:0005524; GO:0005737; GO:0004824; GO:0006430; GO:0003676 ATP binding; cytoplasm; lysine-tRNA ligase activity; lysyl-tRNA aminoacylation; nucleic acid binding IPR004364; IPR018150; IPR006195; IPR002313; IPR018149; IPR012340; IPR004365; "Lysine--tRNA ligase, cytoplasmic (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)" KRS1 GCD5 YDR037W YD9673.09 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40717_c0_g1_i2 Q9C0J8 WDR33_HUMAN 3.00E-50 GO:0005581; GO:0006397; GO:0005634; GO:0006301; GO:0007283 collagen; mRNA processing; nucleus; postreplication repair; spermatogenesis IPR008160; IPR015943; IPR001680; IPR017986; pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein WDC146) WDR33 WDC146 Homo sapiens (Human) TR40717_c2_g1_i1 Q6NLV4 FY_ARATH 1.00E-31 GO:0030154; GO:0009908; GO:0005634 Q9LKF9; Q9FGR0 cell differentiation; flower development; nucleus IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Flowering time control protein FY FY At5g13480 T6I14.10 Arabidopsis thaliana (Mouse-ear cress) TR40718_c4_g1_i1 Q2HJE9 TI17B_BOVIN 1.00E-45 GO:0015450; GO:0016021; GO:0006886; GO:0005744 P-P-bond-hydrolysis-driven protein transmembrane transporter activity; integral to membrane; intracellular protein transport; mitochondrial inner membrane presequence translocase complex IPR005678; IPR003397; Mitochondrial import inner membrane translocase subunit Tim17-B TIMM17B Bos taurus (Bovine) TR40718_c4_g1_i3 Q2HJE9 TI17B_BOVIN 2.00E-23 GO:0015450; GO:0016021; GO:0006886; GO:0005744 P-P-bond-hydrolysis-driven protein transmembrane transporter activity; integral to membrane; intracellular protein transport; mitochondrial inner membrane presequence translocase complex IPR005678; IPR003397; Mitochondrial import inner membrane translocase subunit Tim17-B TIMM17B Bos taurus (Bovine) TR40718_c4_g3_i1 Q5S1U6 IFRD1_PIG 2.00E-39 GO:0007527; GO:0007275; GO:0042692; GO:0005634 adult somatic muscle development; multicellular organismal development; muscle cell differentiation; nucleus IPR011989; IPR016024; IPR006921; IPR007701; Interferon-related developmental regulator 1 IFRD1 Sus scrofa (Pig) TR40718_c4_g3_i2 Q12894 IFRD2_HUMAN 5.00E-29 Q9Y6K5 IPR011989; IPR016024; IPR006921; IPR007701; Interferon-related developmental regulator 2 (Protein SKMC15) IFRD2 Homo sapiens (Human) TR40718_c4_g4_i6 P19182 IFRD1_MOUSE 3.00E-33 GO:0007527; GO:0007275; GO:0042692; GO:0005634 adult somatic muscle development; multicellular organismal development; muscle cell differentiation; nucleus IPR011989; IPR016024; IPR006921; IPR007701; Interferon-related developmental regulator 1 (Nerve growth factor-inducible protein PC4) (TPA-induced sequence 7) (TIS7 protein) Ifrd1 Tis7 Mus musculus (Mouse) TR40719_c0_g1_i10 Q5AFF7 FIS1_CANAL 2.00E-13 GO:0016021; GO:0000266; GO:0005741 integral to membrane; mitochondrial fission; mitochondrial outer membrane IPR016543; IPR028061; IPR028058; IPR013026; IPR011990; IPR019734; Mitochondria fission 1 protein FIS1 CaJ7.0019 CaO19.7111 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) TR40719_c0_g1_i12 Q9CQ92 FIS1_MOUSE 7.00E-29 GO:0035584; GO:0007204; GO:0051561; GO:0031307; GO:0005779; GO:0043653; GO:0008053; GO:0000422; GO:0070584; GO:0016559; GO:0043280; GO:2001244; GO:0090141; GO:0090314; GO:0043234; GO:0051260; GO:0006626; GO:0032471; GO:0001836 calcium-mediated signaling using intracellular calcium source; elevation of cytosolic calcium ion concentration; elevation of mitochondrial calcium ion concentration; integral to mitochondrial outer membrane; integral to peroxisomal membrane; mitochondrial fragmentation involved in apoptotic process; mitochondrial fusion; mitochondrion degradation; mitochondrion morphogenesis; peroxisome fission; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of mitochondrial fission; positive regulation of protein targeting to membrane; protein complex; protein homooligomerization; protein targeting to mitochondrion; reduction of endoplasmic reticulum calcium ion concentration; release of cytochrome c from mitochondria IPR016543; IPR028061; IPR028058; IPR011990; Mitochondrial fission 1 protein (FIS1 homolog) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11) Fis1 Ttc11 Mus musculus (Mouse) TR40719_c0_g1_i2 Q5AFF7 FIS1_CANAL 1.00E-13 GO:0016021; GO:0000266; GO:0005741 integral to membrane; mitochondrial fission; mitochondrial outer membrane IPR016543; IPR028061; IPR028058; IPR013026; IPR011990; IPR019734; Mitochondria fission 1 protein FIS1 CaJ7.0019 CaO19.7111 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) TR40719_c0_g1_i9 Q9CQ92 FIS1_MOUSE 2.00E-29 GO:0035584; GO:0007204; GO:0051561; GO:0031307; GO:0005779; GO:0043653; GO:0008053; GO:0000422; GO:0070584; GO:0016559; GO:0043280; GO:2001244; GO:0090141; GO:0090314; GO:0043234; GO:0051260; GO:0006626; GO:0032471; GO:0001836 calcium-mediated signaling using intracellular calcium source; elevation of cytosolic calcium ion concentration; elevation of mitochondrial calcium ion concentration; integral to mitochondrial outer membrane; integral to peroxisomal membrane; mitochondrial fragmentation involved in apoptotic process; mitochondrial fusion; mitochondrion degradation; mitochondrion morphogenesis; peroxisome fission; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of mitochondrial fission; positive regulation of protein targeting to membrane; protein complex; protein homooligomerization; protein targeting to mitochondrion; reduction of endoplasmic reticulum calcium ion concentration; release of cytochrome c from mitochondria IPR016543; IPR028061; IPR028058; IPR011990; Mitochondrial fission 1 protein (FIS1 homolog) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11) Fis1 Ttc11 Mus musculus (Mouse) TR40721_c1_g1_i1 P20789 NTR1_RAT 8.00E-09 GO:0016492; GO:0008344; GO:0005887 G-protein coupled neurotensin receptor activity; adult locomotory behavior; integral to plasma membrane IPR000276; IPR017452; IPR003985; IPR003984; Neurotensin receptor type 1 (NT-R-1) (NTR1) (High-affinity levocabastine-insensitive neurotensin receptor) (NTRH) Ntsr1 Ntsr Rattus norvegicus (Rat) TR40721_c1_g1_i2 Q9VZW5 FMAR_DROME 2.00E-13 GO:0002209; GO:0007204; GO:0005887; GO:0008345; GO:0008188 behavioral defense response; elevation of cytosolic calcium ion concentration; integral to plasma membrane; larval locomotory behavior; neuropeptide receptor activity IPR000276; IPR017452; FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) TR40722_c0_g1_i1 Q61371 IFT88_MOUSE 0 GO:0009952; GO:0045177; GO:0060411; GO:0005814; GO:0035085; GO:0036064; GO:0060271; GO:0007368; GO:0042733; GO:0048568; GO:0003382; GO:0001654; GO:0048853; GO:0001701; GO:0060426; GO:0031512; GO:0060021; GO:0032391; GO:0045862; GO:0008104; GO:0016485; GO:0042487; GO:0007224; GO:0021513; GO:0021537 anterior/posterior pattern specification; apical part of cell; cardiac septum morphogenesis; centriole; cilium axoneme; cilium basal body; cilium morphogenesis; determination of left/right symmetry; embryonic digit morphogenesis; embryonic organ development; epithelial cell morphogenesis; eye development; forebrain morphogenesis; in utero embryonic development; lung vasculature development; motile primary cilium; palate development; photoreceptor connecting cilium; positive regulation of proteolysis; protein localization; protein processing; regulation of odontogenesis of dentin-containing tooth; smoothened signaling pathway; spinal cord dorsal/ventral patterning; telencephalon development IPR013026; IPR011990; IPR001440; IPR019734; Intraflagellar transport protein 88 homolog (Recessive polycystic kidney disease protein Tg737) (Tetratricopeptide repeat protein 10) (TPR repeat protein 10) (TgN(Imorpk)737Rpw) Ift88 Tg737 Tg737Rpw TgN737Rpw Ttc10 Mus musculus (Mouse) TR40722_c0_g1_i2 Q61371 IFT88_MOUSE 7.00E-152 GO:0009952; GO:0045177; GO:0060411; GO:0005814; GO:0035085; GO:0036064; GO:0060271; GO:0007368; GO:0042733; GO:0048568; GO:0003382; GO:0001654; GO:0048853; GO:0001701; GO:0060426; GO:0031512; GO:0060021; GO:0032391; GO:0045862; GO:0008104; GO:0016485; GO:0042487; GO:0007224; GO:0021513; GO:0021537 anterior/posterior pattern specification; apical part of cell; cardiac septum morphogenesis; centriole; cilium axoneme; cilium basal body; cilium morphogenesis; determination of left/right symmetry; embryonic digit morphogenesis; embryonic organ development; epithelial cell morphogenesis; eye development; forebrain morphogenesis; in utero embryonic development; lung vasculature development; motile primary cilium; palate development; photoreceptor connecting cilium; positive regulation of proteolysis; protein localization; protein processing; regulation of odontogenesis of dentin-containing tooth; smoothened signaling pathway; spinal cord dorsal/ventral patterning; telencephalon development IPR013026; IPR011990; IPR001440; IPR019734; Intraflagellar transport protein 88 homolog (Recessive polycystic kidney disease protein Tg737) (Tetratricopeptide repeat protein 10) (TPR repeat protein 10) (TgN(Imorpk)737Rpw) Ift88 Tg737 Tg737Rpw TgN737Rpw Ttc10 Mus musculus (Mouse) TR40723_c0_g1_i10 Q95JT3 LRC43_MACFA 3.00E-53 IPR001611; Leucine-rich repeat-containing protein 43 LRRC43 QtsA-13548 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR40723_c0_g1_i2 Q95JT3 LRC43_MACFA 1.00E-52 IPR001611; Leucine-rich repeat-containing protein 43 LRRC43 QtsA-13548 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR40723_c0_g1_i3 Q3V0L5 LRC43_MOUSE 8.00E-52 Leucine-rich repeat-containing protein 43 Lrrc43 Gm1061 Mus musculus (Mouse) TR40723_c0_g1_i9 Q95JT3 LRC43_MACFA 2.00E-52 IPR001611; Leucine-rich repeat-containing protein 43 LRRC43 QtsA-13548 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR40725_c0_g2_i4 Q54DM7 PSA2_DICDI 2.00E-24 GO:0005737; GO:0005634; GO:0019773; GO:0006508; GO:0004298; GO:0006511 "cytoplasm; nucleus; proteasome core complex, alpha-subunit complex; proteolysis; threonine-type endopeptidase activity; ubiquitin-dependent protein catabolic process" IPR000426; IPR023332; IPR001353; Proteasome subunit alpha type-2 (EC 3.4.25.1) psmA2 DDB_G0292122 Dictyostelium discoideum (Slime mold) TR40725_c0_g3_i2 P18420 PSA1_RAT 1.00E-81 GO:0005737; GO:0001530; GO:0002862; GO:0005634; GO:0005839; GO:0019773; GO:0004298; GO:0006511 "cytoplasm; lipopolysaccharide binding; negative regulation of inflammatory response to antigenic stimulus; nucleus; proteasome core complex; proteasome core complex, alpha-subunit complex; threonine-type endopeptidase activity; ubiquitin-dependent protein catabolic process" IPR000426; IPR023332; IPR001353; Proteasome subunit alpha type-1 (EC 3.4.25.1) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain) Psma1 Rattus norvegicus (Rat) TR40726_c0_g2_i2 Q15438 CYH1_HUMAN 2.00E-134 GO:0005086; GO:0005737; GO:0090162; GO:0005543; GO:0005886; GO:0032012; GO:0030155; GO:0005923; GO:0016192 O60759 ARF guanyl-nucleotide exchange factor activity; cytoplasm; establishment of epithelial cell polarity; phospholipid binding; plasma membrane; regulation of ARF protein signal transduction; regulation of cell adhesion; tight junction; vesicle-mediated transport IPR011993; IPR001849; IPR023394; IPR000904; "Cytohesin-1 (PH, SEC7 and coiled-coil domain-containing protein 1) (SEC7 homolog B2-1)" CYTH1 D17S811E PSCD1 Homo sapiens (Human) TR40726_c0_g2_i5 Q9UIA0 CYH4_HUMAN 4.00E-120 GO:0005086; GO:0005543; GO:0005886; GO:0032012; GO:0030155 ARF guanyl-nucleotide exchange factor activity; phospholipid binding; plasma membrane; regulation of ARF protein signal transduction; regulation of cell adhesion IPR011993; IPR001849; IPR023394; IPR000904; "Cytohesin-4 (PH, SEC7 and coiled-coil domain-containing protein 4)" CYTH4 CYT4 PSCD4 Homo sapiens (Human) TR40726_c0_g2_i6 Q15438 CYH1_HUMAN 2.00E-134 GO:0005086; GO:0005737; GO:0090162; GO:0005543; GO:0005886; GO:0032012; GO:0030155; GO:0005923; GO:0016192 O60759 ARF guanyl-nucleotide exchange factor activity; cytoplasm; establishment of epithelial cell polarity; phospholipid binding; plasma membrane; regulation of ARF protein signal transduction; regulation of cell adhesion; tight junction; vesicle-mediated transport IPR011993; IPR001849; IPR023394; IPR000904; "Cytohesin-1 (PH, SEC7 and coiled-coil domain-containing protein 1) (SEC7 homolog B2-1)" CYTH1 D17S811E PSCD1 Homo sapiens (Human) TR40729_c1_g3_i1 A5D6U8 PAPL_DANRE 2.00E-163 GO:0003993; GO:0005576; GO:0046872 acid phosphatase activity; extracellular region; metal ion binding IPR004843; IPR008963; IPR015914; IPR025733; Iron/zinc purple acid phosphatase-like protein (EC 3.1.3.2) papl zgc:162913 Danio rerio (Zebrafish) (Brachydanio rerio) TR40729_c1_g3_i2 Q6TPH1 PPA23_ARATH 2.00E-24 GO:0003993; GO:0005576; GO:0046872 acid phosphatase activity; extracellular region; metal ion binding IPR004843; IPR008963; IPR015914; Purple acid phosphatase 23 (EC 3.1.3.2) PAP23 AT3 At4g13700 F18A5.90 Arabidopsis thaliana (Mouse-ear cress) TR40729_c1_g3_i3 A5D6U8 PAPL_DANRE 4.00E-162 GO:0003993; GO:0005576; GO:0046872 acid phosphatase activity; extracellular region; metal ion binding IPR004843; IPR008963; IPR015914; IPR025733; Iron/zinc purple acid phosphatase-like protein (EC 3.1.3.2) papl zgc:162913 Danio rerio (Zebrafish) (Brachydanio rerio) TR4073_c0_g1_i1 P82596 PLC_HALLA 9.00E-22 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR40730_c1_g1_i1 Q54QA6 TRM11_DICDI 4.00E-78 GO:0008168; GO:0000049; GO:0008033 methyltransferase activity; tRNA binding; tRNA processing IPR002052; IPR002296; IPR016691; tRNA (guanine(10)-N2)-methyltransferase homolog (EC 2.1.1.-) (tRNA guanosine-2'-O-methyltransferase TRM11 homolog) trmt11 DDB_G0283969 Dictyostelium discoideum (Slime mold) TR40730_c1_g1_i2 P05409 TMG10_METTL 2.00E-08 GO:0005737; GO:0008168; GO:0000049; GO:0008033 cytoplasm; methyltransferase activity; tRNA binding; tRNA processing IPR002052; IPR002296; IPR000241; Probable tRNA (guanine(10)-N2)-dimethyltransferase (EC 2.1.1.213) (tRNA:G10 dimethyltransferase) (Fragment) trmG10 Methanothermococcus thermolithotrophicus (Methanococcus thermolithotrophicus) TR40730_c1_g1_i4 Q6NS23 TRM11_XENLA 8.00E-145 GO:0008168; GO:0000049; GO:0008033 methyltransferase activity; tRNA binding; tRNA processing IPR002052; IPR002296; IPR000241; IPR016691; tRNA (guanine(10)-N2)-methyltransferase homolog (EC 2.1.1.-) (tRNA guanosine-2'-O-methyltransferase TRM11 homolog) trmt11 Xenopus laevis (African clawed frog) TR40730_c1_g1_i5 Q6NS23 TRM11_XENLA 1.00E-31 GO:0008168; GO:0000049; GO:0008033 methyltransferase activity; tRNA binding; tRNA processing IPR002052; IPR002296; IPR000241; IPR016691; tRNA (guanine(10)-N2)-methyltransferase homolog (EC 2.1.1.-) (tRNA guanosine-2'-O-methyltransferase TRM11 homolog) trmt11 Xenopus laevis (African clawed frog) TR40730_c1_g1_i7 Q5R962 TRM11_PONAB 5.00E-38 GO:0008168; GO:0000049; GO:0008033 methyltransferase activity; tRNA binding; tRNA processing IPR002052; IPR002296; IPR000241; IPR016691; tRNA (guanine(10)-N2)-methyltransferase homolog (EC 2.1.1.-) (tRNA guanosine-2'-O-methyltransferase TRM11 homolog) TRMT11 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40731_c1_g2_i4 O75312 ZPR1_HUMAN 8.00E-170 GO:0008283; GO:0005737; GO:0005730; GO:0007165; GO:0008270 cell proliferation; cytoplasm; nucleolus; signal transduction; zinc ion binding IPR004457; Zinc finger protein ZPR1 (Zinc finger protein 259) ZNF259 ZPR1 Homo sapiens (Human) TR40731_c1_g2_i7 Q55E13 ZPR1_DICDI 9.00E-115 GO:0005634; GO:0008270 nucleus; zinc ion binding IPR004457; Zinc finger protein ZPR1 homolog (Zinc finger protein 259 homolog) zpr1 znf259 DDB_G0269438 Dictyostelium discoideum (Slime mold) TR40731_c1_g2_i9 O75312 ZPR1_HUMAN 4.00E-169 GO:0008283; GO:0005737; GO:0005730; GO:0007165; GO:0008270 cell proliferation; cytoplasm; nucleolus; signal transduction; zinc ion binding IPR004457; Zinc finger protein ZPR1 (Zinc finger protein 259) ZNF259 ZPR1 Homo sapiens (Human) TR40732_c0_g1_i1 Q61006 MUSK_MOUSE 1.00E-13 GO:0005524; GO:0030154; GO:0030054; GO:0005887; GO:0007275; GO:0031594; GO:0043525; GO:2000541; GO:0001934; GO:0045211; GO:0008582; GO:0006355; GO:0071340; GO:0004714 Q18PE0; P46460 "ATP binding; cell differentiation; cell junction; integral to plasma membrane; multicellular organismal development; neuromuscular junction; positive regulation of neuron apoptotic process; positive regulation of protein geranylgeranylation; positive regulation of protein phosphorylation; postsynaptic membrane; regulation of synaptic growth at neuromuscular junction; regulation of transcription, DNA-dependent; skeletal muscle acetylcholine-gated channel clustering; transmembrane receptor protein tyrosine kinase activity" IPR020067; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; "Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)" Musk Nsk2 Mus musculus (Mouse) TR40732_c1_g1_i1 Q6AZB0 BOC_MOUSE 3.00E-12 GO:0030424; GO:0007411; GO:0009986; GO:0016337; GO:0030426; GO:0005887; GO:0043025; GO:0045663; GO:0007224 axon; axon guidance; cell surface; cell-cell adhesion; growth cone; integral to plasma membrane; neuronal cell body; positive regulation of myoblast differentiation; smoothened signaling pathway IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Brother of CDO (Protein BOC) Boc Mus musculus (Mouse) TR40732_c1_g2_i1 A2AJ76 HMCN2_MOUSE 7.00E-58 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 Hmcn2 Mus musculus (Mouse) TR40732_c1_g2_i2 A2AJ76 HMCN2_MOUSE 7.00E-58 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 Hmcn2 Mus musculus (Mouse) TR40732_c1_g3_i2 Q8TD84 DSCL1_HUMAN 1.00E-23 GO:0007409; GO:0007420; GO:0001709; GO:0009986; GO:0070593; GO:0009953; GO:0048704; GO:0007156; GO:0016021; GO:0007162; GO:0005886; GO:0042803 axonogenesis; brain development; cell fate determination; cell surface; dendrite self-avoidance; dorsal/ventral pattern formation; embryonic skeletal system morphogenesis; homophilic cell adhesion; integral to membrane; negative regulation of cell adhesion; plasma membrane; protein homodimerization activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Down syndrome cell adhesion molecule-like protein 1 (Down syndrome cell adhesion molecule 2) DSCAML1 DSCAM2 KIAA1132 Homo sapiens (Human) TR40732_c1_g3_i3 A2AJ76 HMCN2_MOUSE 3.00E-11 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 Hmcn2 Mus musculus (Mouse) TR40733_c3_g2_i7 Q5R8H5 T2EA_PONAB 4.00E-85 GO:0046872; GO:0005634; GO:0006355; GO:0043565; GO:0006367 "metal ion binding; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription initiation from RNA polymerase II promoter" IPR017919; IPR002853; IPR021600; IPR024550; IPR013083; IPR013137; General transcription factor IIE subunit 1 (Transcription initiation factor IIE subunit alpha) (TFIIE-alpha) GTF2E1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40734_c0_g1_i5 Q5RA42 IF1AX_PONAB 9.00E-51 GO:0003743 translation initiation factor activity IPR012340; IPR006196; IPR001253; IPR018104; "Eukaryotic translation initiation factor 1A, X-chromosomal (eIF-1A X isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C)" EIF1AX Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40735_c12_g1_i1 Q9UDV7 ZN282_HUMAN 6.00E-09 GO:0003677; GO:0045892; GO:0005634; GO:0006351; GO:0008270 "DNA binding; negative regulation of transcription, DNA-dependent; nucleus; transcription, DNA-dependent; zinc ion binding" IPR022137; IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1) ZNF282 HUB1 Homo sapiens (Human) TR40735_c15_g1_i1 Q9UH77 KLHL3_HUMAN 8.00E-08 GO:0031463; GO:0005856; GO:0005829; GO:0072156; GO:0050801; GO:0070936; GO:0042787; GO:0070294; GO:0005198 Cul3-RING ubiquitin ligase complex; cytoskeleton; cytosol; distal tubule morphogenesis; ion homeostasis; protein K48-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; renal sodium ion absorption; structural molecule activity IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 3 KLHL3 KIAA1129 Homo sapiens (Human) TR40735_c15_g1_i2 Q86UZ6 ZBT46_HUMAN 1.00E-05 GO:0046872; GO:2001199; GO:0030853; GO:0045650; GO:0045656; GO:0003676; GO:0005634; GO:2001200; GO:0006355; GO:0006351 "metal ion binding; negative regulation of dendritic cell differentiation; negative regulation of granulocyte differentiation; negative regulation of macrophage differentiation; negative regulation of monocyte differentiation; nucleic acid binding; nucleus; positive regulation of dendritic cell differentiation; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 46 (BTB-ZF protein expressed in effector lymphocytes) (BZEL) (BTB/POZ domain-containing protein 4) (Zinc finger protein 340) ZBTB46 BTBD4 ZNF340 Homo sapiens (Human) TR40735_c15_g1_i5 Q9NX65 ZN434_HUMAN 5.00E-09 GO:0003677; GO:0046872; GO:0005634; GO:0000981 P17028 DNA binding; metal ion binding; nucleus; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 32 (Human cervical cancer suppressor gene 5 protein) (HCCS-5) (Zinc finger protein 434) ZSCAN32 ZNF434 HCCS5 Homo sapiens (Human) TR40735_c15_g1_i6 Q9UH77 KLHL3_HUMAN 1.00E-07 GO:0031463; GO:0005856; GO:0005829; GO:0072156; GO:0050801; GO:0070936; GO:0042787; GO:0070294; GO:0005198 Cul3-RING ubiquitin ligase complex; cytoskeleton; cytosol; distal tubule morphogenesis; ion homeostasis; protein K48-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; renal sodium ion absorption; structural molecule activity IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 3 KLHL3 KIAA1129 Homo sapiens (Human) TR40735_c3_g1_i1 Q14590 ZN235_HUMAN 5.00E-09 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) TR40736_c0_g1_i1 Q6P3R8 NEK5_HUMAN 4.00E-64 GO:0005524; GO:0046872; GO:0004674 ATP binding; metal ion binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase Nek5 (EC 2.7.11.1) (Never in mitosis A-related kinase 5) (NimA-related protein kinase 5) NEK5 Homo sapiens (Human) TR40736_c0_g1_i2 P48479 NIM1_NEUCR 5.00E-25 GO:0005524; GO:0051301; GO:0007067; GO:0005634; GO:0050921; GO:0004674 ATP binding; cell division; mitosis; nucleus; positive regulation of chemotaxis; protein serine/threonine kinase activity IPR011009; IPR000719; IPR002290; IPR008271; G2-specific protein kinase nim-1 (EC 2.7.11.1) nim-1 NCU03187 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR40736_c0_g1_i3 P51957 NEK4_HUMAN 2.00E-67 GO:0005524; GO:0051301; GO:0046872; GO:0007067; GO:0005634; GO:0004674 ATP binding; cell division; metal ion binding; mitosis; nucleus; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) NEK4 STK2 Homo sapiens (Human) TR40738_c2_g1_i1 Q5RBG1 RAB5B_PONAB 3.00E-66 GO:0019003; GO:0005525; GO:0031901; GO:0030139; GO:0007032; GO:0042470; GO:0005886; GO:0015031; GO:0030100; GO:0007264 GDP binding; GTP binding; early endosome membrane; endocytic vesicle; endosome organization; melanosome; plasma membrane; protein transport; regulation of endocytosis; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-5B RAB5B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40738_c2_g1_i2 Q54R04 ARL8_DICDI 2.00E-07 GO:0005525; GO:0005622; GO:0007264 GTP binding; intracellular; small GTPase mediated signal transduction IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 8 arl8 arlE DDB_G0283525 Dictyostelium discoideum (Slime mold) TR40739_c1_g1_i1 P56273 MDM2_XENLA 2.00E-17 GO:0005737; GO:0016874; GO:0043066; GO:0071157; GO:0000122; GO:0005730; GO:0005654; GO:0016567; GO:0008270 cytoplasm; ligase activity; negative regulation of apoptotic process; negative regulation of cell cycle arrest; negative regulation of transcription from RNA polymerase II promoter; nucleolus; nucleoplasm; protein ubiquitination; zinc ion binding IPR028340; IPR015459; IPR016495; IPR003121; IPR001876; IPR001841; IPR013083; E3 ubiquitin-protein ligase Mdm2 (EC 6.3.2.-) (Double minute 2 protein) (Xdm2) (p53-binding protein Mdm2) mdm2 Xenopus laevis (African clawed frog) TR40739_c1_g1_i2 O15151 MDM4_HUMAN 2.00E-13 GO:0030330; GO:0045023; GO:0008283; GO:0071456; GO:0043066; GO:0071157; GO:0008285; GO:0042177; GO:0000122; GO:0005634; GO:0008284; GO:0006461; GO:0050821; GO:0008270 P03255-2; Q3YBA8; P10415; P48729; Q00987; Q13064; P06400; P04637; P62837; Q93009; P62258; P61981 "DNA damage response, signal transduction by p53 class mediator; G0 to G1 transition; cell proliferation; cellular response to hypoxia; negative regulation of apoptotic process; negative regulation of cell cycle arrest; negative regulation of cell proliferation; negative regulation of protein catabolic process; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of cell proliferation; protein complex assembly; protein stabilization; zinc ion binding" IPR015458; IPR016495; IPR003121; IPR001876; IPR001841; IPR013083; Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) MDM4 MDMX Homo sapiens (Human) TR40740_c0_g1_i1 Q9UKG1 DP13A_HUMAN 1.00E-99 GO:0006915; GO:0007049; GO:0008283; GO:0005829; GO:0031901; GO:0010008; GO:0008286; GO:0005634; GO:0005543; GO:0043065; GO:0090003; GO:0046324; GO:0012506 Itself; P35609; Q96A54; Q91VH1; Q86V24; Q03001; O75923; P00533; O15379; Q9UL25; P20339; Q8WXH0 apoptotic process; cell cycle; cell proliferation; cytosol; early endosome membrane; endosome membrane; insulin receptor signaling pathway; nucleus; phospholipid binding; positive regulation of apoptotic process; regulation of establishment of protein localization to plasma membrane; regulation of glucose import; vesicle membrane IPR027267; IPR011993; IPR001849; IPR006020; "DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1)" APPL1 APPL DIP13A KIAA1428 Homo sapiens (Human) TR40741_c1_g1_i1 Q6NRB9 EMC1_XENLA 0 GO:0072546 ER membrane protein complex IPR011678; IPR026895; IPR011047; ER membrane protein complex subunit 1 emc1 Xenopus laevis (African clawed frog) TR40742_c1_g2_i1 Q9NBW1 FRIZ4_DROME 3.00E-24 GO:0004930; GO:0030165; GO:0042813; GO:0017147; GO:0007420; GO:0060070; GO:0042995; GO:0005737; GO:0009790; GO:0008406; GO:0016021; GO:0005886; GO:0001944 G-protein coupled receptor activity; PDZ domain binding; Wnt-activated receptor activity; Wnt-protein binding; brain development; canonical Wnt receptor signaling pathway; cell projection; cytoplasm; embryo development; gonad development; integral to membrane; plasma membrane; vasculature development IPR000539; IPR015526; IPR020067; IPR026551; IPR017981; Frizzled-4 (dFz4) fz4 CG4626 Drosophila melanogaster (Fruit fly) TR40742_c1_g2_i2 Q9UP38 FZD1_HUMAN 3.00E-40 GO:0004930; GO:0007199; GO:0007223; GO:0042813; GO:0045177; GO:0035425; GO:0007409; GO:0007420; GO:0044338; GO:0044339; GO:0009986; GO:0005737; GO:0009790; GO:0030855; GO:0008406; GO:0060022; GO:0016021; GO:0048286; GO:0003149; GO:0003150; GO:0030514; GO:0090090; GO:0035414; GO:0045892; GO:0032589; GO:0003151; GO:0090179; GO:0001934; GO:0051091; GO:0045893; GO:0042493; GO:0001944 "G-protein coupled receptor activity; G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; Wnt receptor signaling pathway, calcium modulating pathway; Wnt-activated receptor activity; apical part of cell; autocrine signaling; axonogenesis; brain development; canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation; canonical Wnt receptor signaling pathway involved in osteoblast differentiation; cell surface; cytoplasm; embryo development; epithelial cell differentiation; gonad development; hard palate development; integral to membrane; lung alveolus development; membranous septum morphogenesis; muscular septum morphogenesis; negative regulation of BMP signaling pathway; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of catenin import into nucleus; negative regulation of transcription, DNA-dependent; neuron projection membrane; outflow tract morphogenesis; planar cell polarity pathway involved in neural tube closure; positive regulation of protein phosphorylation; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; response to drug; vasculature development" IPR000539; IPR015526; IPR020067; IPR026548; IPR017981; Frizzled-1 (Fz-1) (hFz1) (FzE1) FZD1 Homo sapiens (Human) TR40742_c1_g2_i3 Q9ULW2 FZD10_HUMAN 5.00E-28 GO:0004930; GO:0030165; GO:0042813; GO:0017147; GO:0007420; GO:0060070; GO:0042995; GO:0009986; GO:0071300; GO:0005737; GO:0009790; GO:0008406; GO:0005887; GO:0034259; GO:0030182; GO:0038031; GO:0043507; GO:0032855; GO:0032956; GO:0001944 G-protein coupled receptor activity; PDZ domain binding; Wnt-activated receptor activity; Wnt-protein binding; brain development; canonical Wnt receptor signaling pathway; cell projection; cell surface; cellular response to retinoic acid; cytoplasm; embryo development; gonad development; integral to plasma membrane; negative regulation of Rho GTPase activity; neuron differentiation; non-canonical Wnt receptor signaling pathway via JNK cascade; positive regulation of JUN kinase activity; positive regulation of Rac GTPase activity; regulation of actin cytoskeleton organization; vasculature development IPR000539; IPR015526; IPR020067; IPR026549; IPR017981; Frizzled-10 (Fz-10) (hFz10) (FzE7) (CD antigen CD350) FZD10 Homo sapiens (Human) TR40742_c1_g2_i5 Q5RCN4 FZD6_PONAB 1.00E-21 GO:0004930; GO:0016055; GO:0042813; GO:0016021; GO:0007275; GO:0005886 G-protein coupled receptor activity; Wnt receptor signaling pathway; Wnt-activated receptor activity; integral to membrane; multicellular organismal development; plasma membrane IPR000539; IPR015526; IPR020067; IPR026543; IPR017981; Frizzled-6 (Fz-6) FZD6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40742_c1_g2_i6 O60353 FZD6_HUMAN 4.00E-20 GO:0004930; GO:0007199; GO:0030165; GO:0060071; GO:0042813; GO:0017147; GO:0001525; GO:0045177; GO:0016327; GO:0007409; GO:0033278; GO:0005737; GO:0001736; GO:0008406; GO:0001942; GO:0042472; GO:0005887; GO:0090090; GO:0043433; GO:0001843; GO:0032589; GO:0035567; GO:0030168 Q8N474 "G-protein coupled receptor activity; G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; PDZ domain binding; Wnt receptor signaling pathway, planar cell polarity pathway; Wnt-activated receptor activity; Wnt-protein binding; angiogenesis; apical part of cell; apicolateral plasma membrane; axonogenesis; cell proliferation in midbrain; cytoplasm; establishment of planar polarity; gonad development; hair follicle development; inner ear morphogenesis; integral to plasma membrane; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of sequence-specific DNA binding transcription factor activity; neural tube closure; neuron projection membrane; non-canonical Wnt receptor signaling pathway; platelet activation" IPR000539; IPR015526; IPR020067; IPR026543; IPR017981; Frizzled-6 (Fz-6) (hFz6) FZD6 Homo sapiens (Human) TR40742_c1_g2_i7 Q24760 FRIZ_DROVI 2.00E-26 GO:0004930; GO:0016055; GO:0007163; GO:0016021; GO:0007275; GO:0005886 G-protein coupled receptor activity; Wnt receptor signaling pathway; establishment or maintenance of cell polarity; integral to membrane; multicellular organismal development; plasma membrane IPR000539; IPR015526; IPR020067; IPR017981; Frizzled (Frizzled-1) (dFz1) fz GJ11377 Drosophila virilis (Fruit fly) TR40742_c1_g2_i8 Q13467 FZD5_HUMAN 8.00E-35 GO:0004930; GO:0000139; GO:0030165; GO:0060061; GO:0033077; GO:0044332; GO:0042813; GO:0001525; GO:0008595; GO:0006915; GO:0060561; GO:0007409; GO:0007420; GO:0060070; GO:0048469; GO:0042995; GO:0009986; GO:0071219; GO:0005737; GO:0031076; GO:0008406; GO:0016021; GO:0060716; GO:0008285; GO:0048471; GO:0005886; GO:0043507; GO:0032729; GO:0045944; GO:0031077 "G-protein coupled receptor activity; Golgi membrane; PDZ domain binding; Spemann organizer formation; T cell differentiation in thymus; Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt-activated receptor activity; angiogenesis; anterior/posterior axis specification, embryo; apoptotic process; apoptotic process involved in morphogenesis; axonogenesis; brain development; canonical Wnt receptor signaling pathway; cell maturation; cell projection; cell surface; cellular response to molecule of bacterial origin; cytoplasm; embryonic camera-type eye development; gonad development; integral to membrane; labyrinthine layer blood vessel development; negative regulation of cell proliferation; perinuclear region of cytoplasm; plasma membrane; positive regulation of JUN kinase activity; positive regulation of interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; post-embryonic camera-type eye development" IPR000539; IPR015526; IPR020067; IPR026547; IPR017981; Frizzled-5 (Fz-5) (hFz5) (FzE5) FZD5 C2orf31 Homo sapiens (Human) TR40743_c0_g1_i1 Q5VX71 SUSD4_HUMAN 1.00E-10 GO:0016021 integral to membrane IPR000436; Sushi domain-containing protein 4 SUSD4 UNQ196/PRO222 Homo sapiens (Human) TR40743_c0_g2_i1 Q4LDE5 SVEP1_HUMAN 6.00E-40 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) TR40743_c1_g1_i1 Q8IWY4 SCUB1_HUMAN 5.00E-17 GO:0007512; GO:0007596; GO:0005509; GO:0045446; GO:0009897; GO:0005615; GO:0019897; GO:0042802; GO:0006954; GO:0009791; GO:0046982; GO:0051260 adult heart development; blood coagulation; calcium ion binding; endothelial cell differentiation; external side of plasma membrane; extracellular space; extrinsic to plasma membrane; identical protein binding; inflammatory response; post-embryonic development; protein heterodimerization activity; protein homooligomerization IPR026823; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR009030; IPR011641; "Signal peptide, CUB and EGF-like domain-containing protein 1" SCUBE1 Homo sapiens (Human) TR40743_c1_g2_i1 Q6NZL8 SCUB1_MOUSE 1.00E-14 GO:0005509; GO:0009897; GO:0005615; GO:0019897; GO:0046982; GO:0051260 calcium ion binding; external side of plasma membrane; extracellular space; extrinsic to plasma membrane; protein heterodimerization activity; protein homooligomerization IPR026823; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR009030; IPR011641; "Signal peptide, CUB and EGF-like domain-containing protein 1" Scube1 Mus musculus (Mouse) TR40743_c2_g1_i1 P98105 LYAM2_RAT 1.00E-20 GO:0030029; GO:0007202; GO:0005901; GO:0007155; GO:0005905; GO:0030863; GO:0005615; GO:0007157; GO:0006954; GO:0016021; GO:0050900; GO:0050901; GO:0070492; GO:0048471; GO:0002092; GO:0034097; GO:0070555; GO:0033691; GO:0004888 actin filament-based process; activation of phospholipase C activity; caveola; cell adhesion; coated pit; cortical cytoskeleton; extracellular space; heterophilic cell-cell adhesion; inflammatory response; integral to membrane; leukocyte migration; leukocyte tethering or rolling; oligosaccharide binding; perinuclear region of cytoplasm; positive regulation of receptor internalization; response to cytokine stimulus; response to interleukin-1; sialic acid binding; transmembrane signaling receptor activity IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR002396; IPR000436; E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E) Sele Elam-1 Rattus norvegicus (Rat) TR40743_c2_g2_i1 Q6GP28 SRPX2_XENLA 1.00E-15 GO:0001525; GO:0007155; GO:0005737; GO:0005576 angiogenesis; cell adhesion; cytoplasm; extracellular region IPR025232; IPR003410; IPR000436; Sushi repeat-containing protein SRPX2 srpx2 Xenopus laevis (African clawed frog) TR40743_c3_g1_i1 Q6VE48 MCP_BOVIN 8.00E-22 GO:0006958; GO:0045087; GO:0002079; GO:0016021; GO:0007338 "complement activation, classical pathway; innate immune response; inner acrosomal membrane; integral to membrane; single fertilization" IPR017341; IPR000436; Membrane cofactor protein (CD antigen CD46) CD46 MCP Bos taurus (Bovine) TR40743_c3_g1_i2 P16109 LYAM3_HUMAN 1.00E-59 GO:0050829; GO:0009897; GO:0005615; GO:0042806; GO:0043208; GO:0008201; GO:0007157; GO:0006954; GO:0005887; GO:0007159; GO:0050900; GO:0050901; GO:0001530; GO:0005634; GO:0070492; GO:0030168; GO:0031092; GO:0002576; GO:0031088; GO:0002687; GO:0014068; GO:0010572; GO:0033623; GO:0032496; GO:0033691 defense response to Gram-negative bacterium; external side of plasma membrane; extracellular space; fucose binding; glycosphingolipid binding; heparin binding; heterophilic cell-cell adhesion; inflammatory response; integral to plasma membrane; leukocyte cell-cell adhesion; leukocyte migration; leukocyte tethering or rolling; lipopolysaccharide binding; nucleus; oligosaccharide binding; platelet activation; platelet alpha granule membrane; platelet degranulation; platelet dense granule membrane; positive regulation of leukocyte migration; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of platelet activation; regulation of integrin activation; response to lipopolysaccharide; sialic acid binding IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR002396; IPR000436; P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P) SELP GMRP GRMP Homo sapiens (Human) TR40743_c3_g2_i1 P98109 LYAM3_SHEEP 1.00E-53 GO:0030246; GO:0007155; GO:0016021 carbohydrate binding; cell adhesion; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR002396; IPR000436; P-selectin (CD62 antigen-like family member P) (CD62P antigen) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62) SELP Ovis aries (Sheep) TR40743_c4_g1_i1 P47971 NPTX1_RAT 7.00E-30 GO:0060385; GO:0071333; GO:0035865; GO:0046872; GO:0043653; GO:0006839; GO:0005739; GO:0043005; GO:0005886; GO:0030133 axonogenesis involved in innervation; cellular response to glucose stimulus; cellular response to potassium ion; metal ion binding; mitochondrial fragmentation involved in apoptotic process; mitochondrial transport; mitochondrion; neuron projection; plasma membrane; transport vesicle IPR008985; IPR013320; IPR001759; Neuronal pentraxin-1 (NP1) (47 kDa taipoxin-binding protein) (Neuronal pentraxin I) (NP-I) Nptx1 Rattus norvegicus (Rat) TR40743_c5_g1_i1 Q4LDE5 SVEP1_HUMAN 2.00E-131 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) TR40743_c5_g2_i1 Q8N2E2 VWDE_HUMAN 2.00E-17 GO:0005576 extracellular region IPR000742; IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) TR40743_c5_g2_i2 P97677 DLL1_RAT 3.00E-09 GO:0005112; GO:0007219; GO:0009912; GO:0005509; GO:0001709; GO:0016021; GO:0005886 Notch binding; Notch signaling pathway; auditory receptor cell fate commitment; calcium ion binding; cell fate determination; integral to membrane; plasma membrane IPR001774; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR011651; Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1) Dll1 Rattus norvegicus (Rat) TR40743_c5_g3_i1 P16581 LYAM2_HUMAN 3.00E-41 GO:0030029; GO:0007202; GO:0007596; GO:0019722; GO:0005901; GO:0005905; GO:0030863; GO:0005615; GO:0007157; GO:0016021; GO:0002523; GO:0050901; GO:0070492; GO:0048471; GO:0043274; GO:0002687; GO:0002092; GO:0050727; GO:0070555; GO:0032496; GO:0034612; GO:0033691; GO:0004888 actin filament-based process; activation of phospholipase C activity; blood coagulation; calcium-mediated signaling; caveola; coated pit; cortical cytoskeleton; extracellular space; heterophilic cell-cell adhesion; integral to membrane; leukocyte migration involved in inflammatory response; leukocyte tethering or rolling; oligosaccharide binding; perinuclear region of cytoplasm; phospholipase binding; positive regulation of leukocyte migration; positive regulation of receptor internalization; regulation of inflammatory response; response to interleukin-1; response to lipopolysaccharide; response to tumor necrosis factor; sialic acid binding; transmembrane signaling receptor activity IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR002396; IPR000436; E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E) SELE ELAM1 Homo sapiens (Human) TR40743_c5_g3_i2 O62685 MCP_SAISC 4.00E-22 GO:0006958; GO:0045087; GO:0002079; GO:0007338 "complement activation, classical pathway; innate immune response; inner acrosomal membrane; single fertilization" IPR017341; IPR000436; Membrane cofactor protein (CD antigen CD46) (Fragment) CD46 MCP Saimiri sciureus (Common squirrel monkey) TR40743_c5_g4_i1 Q7Z407 CSMD3_HUMAN 3.00E-64 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 3 (CUB and sushi multiple domains protein 3) CSMD3 KIAA1894 Homo sapiens (Human) TR40743_c6_g1_i1 P10079 FBP1_STRPU 8.00E-49 GO:0032579; GO:0005509; GO:0016023; GO:0005615 apical lamina of hyaline layer; calcium ion binding; cytoplasmic membrane-bounded vesicle; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) TR40744_c0_g1_i1 Q5F408 SYCC_CHICK 0 GO:0005524; GO:0004817; GO:0006423; GO:0005829; GO:0046872; GO:0000049 ATP binding; cysteine-tRNA ligase activity; cysteinyl-tRNA aminoacylation; cytosol; metal ion binding; tRNA binding IPR015803; IPR024909; IPR014729; IPR009080; "Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)" CARS RCJMB04_3o5 Gallus gallus (Chicken) TR40744_c0_g1_i2 Q2IUP0 SYC_RHOP2 7.00E-44 GO:0005524; GO:0004817; GO:0006423; GO:0005737; GO:0008270 ATP binding; cysteine-tRNA ligase activity; cysteinyl-tRNA aminoacylation; cytoplasm; zinc ion binding IPR015803; IPR015273; IPR024909; IPR014729; IPR009080; Cysteine--tRNA ligase (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS) cysS RPB_3374 Rhodopseudomonas palustris (strain HaA2) TR40744_c0_g1_i3 Q97S25 SYC_STRPN 5.00E-61 GO:0005524; GO:0004817; GO:0006423; GO:0005737; GO:0008270 ATP binding; cysteine-tRNA ligase activity; cysteinyl-tRNA aminoacylation; cytoplasm; zinc ion binding IPR015803; IPR015273; IPR024909; IPR014729; IPR009080; Cysteine--tRNA ligase (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS) cysS SP_0591 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) TR40744_c0_g1_i4 Q9ER72 SYCC_MOUSE 0 GO:0005524; GO:0004817; GO:0006423; GO:0005829; GO:0046872; GO:0000049 ATP binding; cysteine-tRNA ligase activity; cysteinyl-tRNA aminoacylation; cytosol; metal ion binding; tRNA binding IPR015803; IPR024909; IPR010987; IPR014729; IPR009080; "Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)" Cars Mus musculus (Mouse) TR40745_c1_g1_i2 Q0WYX8 MDGA1_CHICK 4.00E-15 GO:0046658; GO:0001764 anchored to plasma membrane; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 MDGA1 Gallus gallus (Chicken) TR40745_c1_g1_i3 Q8CG85 MAMC2_MOUSE 2.00E-07 GO:0005783; GO:0005539; GO:0005614; GO:0016020; GO:0019800 endoplasmic reticulum; glycosaminoglycan binding; interstitial matrix; membrane; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IPR008985; IPR000998; MAM domain-containing protein 2 (MAM domain-containing proteoglycan) (Mamcan) Mamdc2 Mus musculus (Mouse) TR40745_c1_g1_i4 Q5VYJ5 CJ112_HUMAN 1.00E-06 GO:0016021 integral to membrane IPR008985; IPR023415; IPR002172; IPR000998; MAM and LDL-receptor class A domain-containing protein C10orf112 C10orf112 Homo sapiens (Human) TR40746_c2_g1_i1 Q9D4H2 GCC1_MOUSE 9.00E-98 GO:0000139; GO:0005886; GO:0000042 Golgi membrane; plasma membrane; protein targeting to Golgi IPR000237; GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1) Gcc1 Mus musculus (Mouse) TR40746_c2_g1_i5 Q96CN9 GCC1_HUMAN 1.00E-31 GO:0005794; GO:0000139; GO:0005886; GO:0000042 Q14134 Golgi apparatus; Golgi membrane; plasma membrane; protein targeting to Golgi IPR000237; GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1) GCC1 Homo sapiens (Human) TR40747_c4_g1_i11 Q5TYV4 SPE39_DANRE 6.00E-70 GO:0030154; GO:0005737; GO:0016023; GO:0005769; GO:0061008; GO:0005770; GO:0015031; GO:0055037; GO:0006355; GO:0007283; GO:0006351 "cell differentiation; cytoplasm; cytoplasmic membrane-bounded vesicle; early endosome; hepaticobiliary system development; late endosome; protein transport; recycling endosome; regulation of transcription, DNA-dependent; spermatogenesis; transcription, DNA-dependent" IPR019177; Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) vipas39 spe39 vipar si:ch211-20b12.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR40747_c4_g1_i2 Q5TYV4 SPE39_DANRE 9.00E-84 GO:0030154; GO:0005737; GO:0016023; GO:0005769; GO:0061008; GO:0005770; GO:0015031; GO:0055037; GO:0006355; GO:0007283; GO:0006351 "cell differentiation; cytoplasm; cytoplasmic membrane-bounded vesicle; early endosome; hepaticobiliary system development; late endosome; protein transport; recycling endosome; regulation of transcription, DNA-dependent; spermatogenesis; transcription, DNA-dependent" IPR019177; Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) vipas39 spe39 vipar si:ch211-20b12.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR40747_c4_g1_i4 Q23288 SPE39_CAEEL 2.00E-24 GO:0005737; GO:0016023; GO:0005769; GO:0005770; GO:0015031; GO:0055037; GO:0006355; GO:0007286; GO:0006351; GO:0006624; GO:0007034 "cytoplasm; cytoplasmic membrane-bounded vesicle; early endosome; late endosome; protein transport; recycling endosome; regulation of transcription, DNA-dependent; spermatid development; transcription, DNA-dependent; vacuolar protein processing; vacuolar transport" IPR019177; Spermatogenesis-defective protein 39 (SPE-39) (VPS33B-interacting protein in polarity and apical restriction) spe-39 vipar ZC404.3 Caenorhabditis elegans TR40747_c4_g1_i5 Q5TYV4 SPE39_DANRE 4.00E-85 GO:0030154; GO:0005737; GO:0016023; GO:0005769; GO:0061008; GO:0005770; GO:0015031; GO:0055037; GO:0006355; GO:0007283; GO:0006351 "cell differentiation; cytoplasm; cytoplasmic membrane-bounded vesicle; early endosome; hepaticobiliary system development; late endosome; protein transport; recycling endosome; regulation of transcription, DNA-dependent; spermatogenesis; transcription, DNA-dependent" IPR019177; Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) vipas39 spe39 vipar si:ch211-20b12.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR40748_c1_g2_i1 Q93212 SOL1_CAEEL 1.00E-35 GO:0030054; GO:0016247; GO:0006972; GO:0008328; GO:0032589; GO:0051968; GO:0045211; GO:0040012; GO:0045202; GO:0001966 "cell junction; channel regulator activity; hyperosmotic response; ionotropic glutamate receptor complex; neuron projection membrane; positive regulation of synaptic transmission, glutamatergic; postsynaptic membrane; regulation of locomotion; synapse; thigmotaxis" IPR000859; Suppressor of lurcher protein 1 sol-1 C15A11.3 Caenorhabditis elegans TR40748_c1_g2_i5 Q91ZV3 DCBD2_MOUSE 3.00E-07 GO:0007155; GO:0009986; GO:0005887; GO:0030308; GO:0042060 cell adhesion; cell surface; integral to plasma membrane; negative regulation of cell growth; wound healing IPR000421; IPR000859; IPR008979; IPR004043; "Discoidin, CUB and LCCL domain-containing protein 2 (Endothelial and smooth muscle cell-derived neuropilin-like protein)" Dcbld2 Esdn Mus musculus (Mouse) TR40748_c1_g2_i6 Q93212 SOL1_CAEEL 1.00E-35 GO:0030054; GO:0016247; GO:0006972; GO:0008328; GO:0032589; GO:0051968; GO:0045211; GO:0040012; GO:0045202; GO:0001966 "cell junction; channel regulator activity; hyperosmotic response; ionotropic glutamate receptor complex; neuron projection membrane; positive regulation of synaptic transmission, glutamatergic; postsynaptic membrane; regulation of locomotion; synapse; thigmotaxis" IPR000859; Suppressor of lurcher protein 1 sol-1 C15A11.3 Caenorhabditis elegans TR40748_c1_g2_i7 P42664 UVS2_XENLA 6.00E-10 GO:0004222; GO:0006508; GO:0008270 metalloendopeptidase activity; proteolysis; zinc ion binding IPR000859; IPR017370; IPR024079; IPR001506; IPR006026; Embryonic protein UVS.2 (EC 3.4.24.-) Xenopus laevis (African clawed frog) TR40749_c1_g1_i1 Q5VYJ5 CJ112_HUMAN 1.00E-21 GO:0016021 integral to membrane IPR008985; IPR023415; IPR002172; IPR000998; MAM and LDL-receptor class A domain-containing protein C10orf112 C10orf112 Homo sapiens (Human) TR40749_c1_g1_i2 P85171 MDGA1_RAT 1.00E-20 GO:0046658; GO:0007420; GO:0001764; GO:0021527 anchored to plasma membrane; brain development; neuron migration; spinal cord association neuron differentiation IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (Ig6M) Mdga1 Rattus norvegicus (Rat) TR40749_c1_g1_i3 P68638 VCP_VACCW 1.00E-07 GO:0020002; GO:0016021; GO:0039573; GO:0055036 host cell plasma membrane; integral to membrane; suppression by virus of host complement activation; virion membrane IPR011176; IPR000436; Complement control protein C3 (28 kDa protein) (Secretory protein 35) (Protein C3) (VCP) VACWR025 C3L Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) TR40750_c1_g1_i1 P13195 HEM1_RAT 0 GO:0003870; GO:0032869; GO:0071407; GO:0005759; GO:0005739; GO:0006782; GO:0030170; GO:0051591; GO:0032025; GO:0042493; GO:0045471; GO:0034698; GO:0009635; GO:0001666; GO:0010045; GO:0031667; GO:0070541 5-aminolevulinate synthase activity; cellular response to insulin stimulus; cellular response to organic cyclic compound; mitochondrial matrix; mitochondrion; protoporphyrinogen IX biosynthetic process; pyridoxal phosphate binding; response to cAMP; response to cobalt ion; response to drug; response to ethanol; response to gonadotropin stimulus; response to herbicide; response to hypoxia; response to nickel cation; response to nutrient levels; response to platinum ion IPR010961; IPR015118; IPR001917; IPR004839; IPR015424; IPR015421; IPR015422; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1. "5-aminolevulinate synthase, nonspecific, mitochondrial (ALAS-H) (EC 2.3.1.37) (5-aminolevulinic acid synthase 1) (Delta-ALA synthase 1) (Delta-aminolevulinate synthase 1)" Alas1 Rattus norvegicus (Rat) TR40750_c1_g1_i2 Q9YHT4 HEM0_DANRE 0 GO:0003870; GO:0035162; GO:0030218; GO:0006783; GO:0042541; GO:0005743; GO:0005759; GO:0006782; GO:0030170; GO:0001666 5-aminolevulinate synthase activity; embryonic hemopoiesis; erythrocyte differentiation; heme biosynthetic process; hemoglobin biosynthetic process; mitochondrial inner membrane; mitochondrial matrix; protoporphyrinogen IX biosynthetic process; pyridoxal phosphate binding; response to hypoxia IPR010961; IPR015118; IPR001917; IPR004839; IPR015424; IPR015421; IPR015422; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1. "5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS-E) (EC 2.3.1.37) (5-aminolevulinic acid synthase 2) (Delta-ALA synthase 2) (Delta-aminolevulinate synthase 2)" alas2 alas-e Danio rerio (Zebrafish) (Brachydanio rerio) TR40750_c1_g1_i3 Q9XS79 HEM1_DELLE 0 GO:0003870; GO:0005759; GO:0006782; GO:0030170 5-aminolevulinate synthase activity; mitochondrial matrix; protoporphyrinogen IX biosynthetic process; pyridoxal phosphate binding IPR010961; IPR015118; IPR001917; IPR004839; IPR015424; IPR015421; IPR015422; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1. "5-aminolevulinate synthase, nonspecific, mitochondrial (ALAS-H) (EC 2.3.1.37) (5-aminolevulinic acid synthase 1) (Delta-ALA synthase 1) (Delta-aminolevulinate synthase 1)" ALAS1 ALS1 Delphinapterus leucas (Beluga whale) TR40751_c0_g2_i1 Q9JMJ2 FBXW4_MOUSE 8.00E-41 GO:0016055; GO:0051216; GO:0042733; GO:0002053 Wnt receptor signaling pathway; cartilage development; embryonic digit morphogenesis; positive regulation of mesenchymal cell proliferation IPR001810; IPR015943; IPR001680; IPR017986; F-box/WD repeat-containing protein 4 (F-box and WD-40 domain-containing protein 4) (Protein hagoromo) Fbxw4 Fbw4 Mus musculus (Mouse) TR40751_c0_g2_i2 P39014 MET30_YEAST 1.00E-08 GO:0006270; GO:0031146; GO:0019344; GO:0005737; GO:0009086; GO:0043224; GO:0000209; GO:0030174; GO:0000083; GO:0046685; GO:0046686; GO:0006351; GO:0043130 Itself; Q12018; P32389; P52286; Q12020 "DNA replication initiation; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cysteine biosynthetic process; cytoplasm; methionine biosynthetic process; nuclear SCF ubiquitin ligase complex; protein polyubiquitination; regulation of DNA-dependent DNA replication initiation; regulation of transcription involved in G1/S transition of mitotic cell cycle; response to arsenic-containing substance; response to cadmium ion; transcription, DNA-dependent; ubiquitin binding" IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. F-box protein MET30 (E3 ubiquitin ligase complex SCF(Met30) subunit MET30) (Methionine-requiring protein 30) MET30 YIL046W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40752_c0_g1_i1 O14841 OPLA_HUMAN 0 GO:0017168; GO:0005524; GO:0005829; GO:0006750; GO:1901687; GO:0006805 5-oxoprolinase (ATP-hydrolyzing) activity; ATP binding; cytosol; glutathione biosynthetic process; glutathione derivative biosynthetic process; xenobiotic metabolic process IPR008040; IPR002821; IPR003692; 5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Pyroglutamase) OPLAH Homo sapiens (Human) TR40752_c0_g1_i2 Q58373 Y963_METJA 1.00E-85 GO:0003824; GO:0008152 catalytic activity; metabolic process IPR003692; Uncharacterized protein MJ0963 MJ0963 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR40752_c0_g1_i3 O14841 OPLA_HUMAN 0 GO:0017168; GO:0005524; GO:0005829; GO:0006750; GO:1901687; GO:0006805 5-oxoprolinase (ATP-hydrolyzing) activity; ATP binding; cytosol; glutathione biosynthetic process; glutathione derivative biosynthetic process; xenobiotic metabolic process IPR008040; IPR002821; IPR003692; 5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Pyroglutamase) OPLAH Homo sapiens (Human) TR40752_c0_g1_i5 Q10093 YAOE_SCHPO 0 GO:0017168; GO:0005829; GO:0006749 5-oxoprolinase (ATP-hydrolyzing) activity; cytosol; glutathione metabolic process IPR008040; IPR002821; IPR003692; Uncharacterized protein C11D3.14c SPAC11D3.14c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40752_c0_g2_i1 Q01262 HYUA_PSESN 7.00E-43 GO:0008652; GO:0016787 cellular amino acid biosynthetic process; hydrolase activity IPR008040; IPR002821; Hydantoin utilization protein A (ORF2) hyuA Pseudomonas sp. (strain NS671) TR40753_c0_g2_i2 P19477 FIBA_PARPA 5.00E-29 IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein A (FREP-A) Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) TR40753_c0_g2_i3 P55918 MFAP4_BOVIN 3.00E-41 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR014716; IPR014715; IPR002181; Microfibril-associated glycoprotein 4 (36 kDa microfibril-associated glycoprotein) (36 kDa MAP) MFAP4 Bos taurus (Bovine) TR40753_c0_g2_i4 E2IYB3 FCNV1_VARKO 2.00E-16 GO:0005576 extracellular region IPR008160; IPR014716; IPR002181; Veficolin-1 (Fragment) Varanus komodoensis (Komodo dragon) TR40754_c1_g1_i2 P98073 ENTK_HUMAN 6.00E-16 GO:0005903; GO:0016021; GO:0006508; GO:0005044; GO:0004252 brush border; integral to membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity IPR008985; IPR000859; IPR023415; IPR002172; IPR000998; IPR001254; IPR018114; IPR001314; IPR000082; IPR001190; IPR017448; IPR009003; Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain] TMPRSS15 ENTK PRSS7 Homo sapiens (Human) TR40754_c2_g2_i1 P08217 CEL2A_HUMAN 5.00E-12 GO:0005576; GO:0006508; GO:0004252 extracellular region; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Chymotrypsin-like elastase family member 2A (EC 3.4.21.71) (Elastase-2A) CELA2A ELA2A Homo sapiens (Human) TR40754_c2_g2_i2 P26262 KLKB1_MOUSE 7.00E-12 GO:0007596; GO:0005576; GO:0042730; GO:0006954; GO:0006508; GO:0004252 blood coagulation; extracellular region; fibrinolysis; inflammatory response; proteolysis; serine-type endopeptidase activity IPR000177; IPR003014; IPR003609; IPR001254; IPR018114; IPR001314; IPR009003; Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain] Klkb1 Klk3 Pk Mus musculus (Mouse) TR40754_c2_g2_i4 P69526 TMPS9_RAT 3.00E-28 GO:0005887; GO:0006508; GO:0004252 integral to plasma membrane; proteolysis; serine-type endopeptidase activity IPR002172; IPR017324; IPR001254; IPR018114; IPR001314; IPR009003; Transmembrane protease serine 9 (EC 3.4.21.-) (Polyserase-I) (Polyserine protease 1) (Polyserase-1) [Cleaved into: Serase-1; Serase-2; Serase-3] Tmprss9 Rattus norvegicus (Rat) TR40754_c2_g2_i5 Q9Y6M0 TEST_HUMAN 6.00E-33 GO:0031225; GO:0005737; GO:0005886; GO:0006508; GO:0004252; GO:0008236 P36952 anchored to membrane; cytoplasm; plasma membrane; proteolysis; serine-type endopeptidase activity; serine-type peptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Testisin (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP-1) (Serine protease 21) PRSS21 ESP1 TEST1 UNQ266/PRO303 Homo sapiens (Human) TR40754_c2_g2_i6 Q9CQ52 CEL3B_MOUSE 2.00E-29 GO:0006508; GO:0004252 proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Chymotrypsin-like elastase family member 3B (EC 3.4.21.70) (Elastase IIIB) (Elastase-3B) (Protease E) Cela3b Ela3 Ela3b Mus musculus (Mouse) TR40754_c2_g2_i7 Q6IE14 TM11L_RAT 6.00E-31 GO:0005576; GO:0005887; GO:0006508; GO:0004252 extracellular region; integral to plasma membrane; proteolysis; serine-type endopeptidase activity IPR017329; IPR001254; IPR018114; IPR001314; IPR000082; IPR009003; Transmembrane protease serine 11B-like protein (EC 3.4.21.-) (Airway trypsin-like protease 5) (Transmembrane protease serine 11B) Tmprss11bnl Hatl5 Tmprss11b Rattus norvegicus (Rat) TR40755_c2_g1_i2 Q5F3D1 ZCHC8_CHICK 2.00E-48 GO:0003676; GO:0008270 nucleic acid binding; zinc ion binding IPR006568; IPR001878; Zinc finger CCHC domain-containing protein 8 ZCCHC8 RCJMB04_21c10 Gallus gallus (Chicken) TR40756_c0_g2_i2 Q5R4F8 C42S2_PONAB 1.00E-24 GO:0042995; GO:0005737; GO:0005856; GO:0001891; GO:0006909; GO:0005886; GO:0008360; GO:0009966; GO:0005198 cell projection; cytoplasm; cytoskeleton; phagocytic cup; phagocytosis; plasma membrane; regulation of cell shape; regulation of signal transduction; structural molecule activity IPR000095; CDC42 small effector protein 2 CDC42SE2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40756_c0_g2_i3 A1L1K4 C42S2_RAT 1.00E-23 GO:0042995; GO:0005737; GO:0005856; GO:0001891; GO:0006909; GO:0005886; GO:0008360; GO:0009966; GO:0005198 cell projection; cytoplasm; cytoskeleton; phagocytic cup; phagocytosis; plasma membrane; regulation of cell shape; regulation of signal transduction; structural molecule activity IPR000095; CDC42 small effector protein 2 Cdc42se2 Rattus norvegicus (Rat) TR40756_c0_g2_i6 Q5R4F8 C42S2_PONAB 9.00E-25 GO:0042995; GO:0005737; GO:0005856; GO:0001891; GO:0006909; GO:0005886; GO:0008360; GO:0009966; GO:0005198 cell projection; cytoplasm; cytoskeleton; phagocytic cup; phagocytosis; plasma membrane; regulation of cell shape; regulation of signal transduction; structural molecule activity IPR000095; CDC42 small effector protein 2 CDC42SE2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40756_c0_g2_i7 Q5BJM7 C42S1_RAT 2.00E-11 GO:0005856; GO:0005739; GO:0006909; GO:0005886; GO:0008360 cytoskeleton; mitochondrion; phagocytosis; plasma membrane; regulation of cell shape IPR000095; CDC42 small effector protein 1 Cdc42se1 Rattus norvegicus (Rat) TR40756_c0_g2_i8 Q5R4F8 C42S2_PONAB 4.00E-26 GO:0042995; GO:0005737; GO:0005856; GO:0001891; GO:0006909; GO:0005886; GO:0008360; GO:0009966; GO:0005198 cell projection; cytoplasm; cytoskeleton; phagocytic cup; phagocytosis; plasma membrane; regulation of cell shape; regulation of signal transduction; structural molecule activity IPR000095; CDC42 small effector protein 2 CDC42SE2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40757_c0_g1_i1 Q8K0U4 HS12A_MOUSE 5.00E-91 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR40757_c1_g1_i1 Q6MB26 DNAK_PARUW 1.00E-13 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK pc1499 Protochlamydia amoebophila (strain UWE25) TR40757_c1_g1_i2 B9E6X1 DNAK_MACCJ 2.00E-08 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK MCCL_1232 Macrococcus caseolyticus (strain JCSC5402) TR40757_c1_g1_i4 A4G8D2 DNAK_HERAR 1.00E-08 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK HEAR2647 Herminiimonas arsenicoxydans TR40757_c1_g1_i5 O43301 HS12A_HUMAN 3.00E-74 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR40758_c2_g2_i1 Q8UWA5 CAH2_TRIHK 1.00E-45 GO:0004089; GO:0005737; GO:0006730; GO:0005886; GO:0008270 carbonate dehydratase activity; cytoplasm; one-carbon metabolic process; plasma membrane; zinc ion binding IPR001148; IPR023561; IPR018338; Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II) ca2 Tribolodon hakonensis (Big-scaled redfin) (Leuciscus hakonensis) TR40758_c2_g2_i3 Q9ULX7 CAH14_HUMAN 1.00E-44 GO:0015701; GO:0004089; GO:0016021; GO:0046872; GO:0005886; GO:0044281 bicarbonate transport; carbonate dehydratase activity; integral to membrane; metal ion binding; plasma membrane; small molecule metabolic process IPR018429; IPR001148; IPR023561; Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV) CA14 UNQ690/PRO1335 Homo sapiens (Human) TR40760_c1_g2_i1 Q64148 CP3AA_MESAU 3.00E-127 GO:0005789; GO:0020037; GO:0005506; GO:0033777; GO:0016712 "endoplasmic reticulum membrane; heme binding; iron ion binding; lithocholate 6beta-hydroxylase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen" IPR001128; IPR017972; IPR008072; IPR002402; Lithocholate 6-beta-hydroxylase (6 beta-hydroxylase) (EC 1.14.13.94) (CYPIIIA10) (Cytochrome P450 3A10) CYP3A10 Mesocricetus auratus (Golden hamster) TR40760_c1_g2_i3 Q64148 CP3AA_MESAU 4.00E-65 GO:0005789; GO:0020037; GO:0005506; GO:0033777; GO:0016712 "endoplasmic reticulum membrane; heme binding; iron ion binding; lithocholate 6beta-hydroxylase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen" IPR001128; IPR017972; IPR008072; IPR002402; Lithocholate 6-beta-hydroxylase (6 beta-hydroxylase) (EC 1.14.13.94) (CYPIIIA10) (Cytochrome P450 3A10) CYP3A10 Mesocricetus auratus (Golden hamster) TR40761_c2_g1_i1 A5PJX7 S6A13_BOVIN 7.00E-74 GO:0005332; GO:0005887; GO:0005328 gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR002981; Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13) SLC6A13 Bos taurus (Bovine) TR40761_c2_g1_i3 P23978 SC6A1_RAT 1.00E-66 GO:0030424; GO:0009986; GO:0051939; GO:0005332; GO:0005887; GO:0007612; GO:0032229; GO:0043005; GO:0005328; GO:0005886; GO:0014054; GO:0051260; GO:0051592; GO:0042220; GO:0032355; GO:0010288; GO:0014074; GO:0009744; GO:0009636 "axon; cell surface; gamma-aminobutyric acid import; gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; learning; negative regulation of synaptic transmission, GABAergic; neuron projection; neurotransmitter:sodium symporter activity; plasma membrane; positive regulation of gamma-aminobutyric acid secretion; protein homooligomerization; response to calcium ion; response to cocaine; response to estradiol stimulus; response to lead ion; response to purine-containing compound; response to sucrose stimulus; response to toxic substance" IPR000175; IPR002980; Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) Slc6a1 Gabt1 Gat-1 Gat1 Rattus norvegicus (Rat) TR40761_c2_g1_i5 A7Y2W8 SC6A9_XENLA 1.00E-78 GO:0005887; GO:0005328; GO:0005283 integral to plasma membrane; neurotransmitter:sodium symporter activity; sodium:amino acid symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9) slc6a9 glyt1 Xenopus laevis (African clawed frog) TR40761_c2_g2_i2 P31662 S6A17_RAT 1.00E-31 GO:0032328; GO:0030054; GO:0015816; GO:0005887; GO:0015820; GO:0005328; GO:0015824; GO:0008021; GO:0030672 alanine transport; cell junction; glycine transport; integral to plasma membrane; leucine transport; neurotransmitter:sodium symporter activity; proline transport; synaptic vesicle; synaptic vesicle membrane IPR000175; IPR002438; Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17) Slc6a17 Ntt4 Rxt1 Rattus norvegicus (Rat) TR40761_c2_g2_i4 P48065 S6A12_HUMAN 1.00E-48 GO:0006865; GO:0071474; GO:0009992; GO:0005332; GO:0016021; GO:0005887; GO:0007269; GO:0005328; GO:0005886; GO:0010033; GO:0055085 amino acid transport; cellular hyperosmotic response; cellular water homeostasis; gamma-aminobutyric acid:sodium symporter activity; integral to membrane; integral to plasma membrane; neurotransmitter secretion; neurotransmitter:sodium symporter activity; plasma membrane; response to organic substance; transmembrane transport IPR000175; IPR002983; Sodium- and chloride-dependent betaine transporter (BGT-1) (Na(+)/Cl(-) betaine/GABA transporter) (Solute carrier family 6 member 12) SLC6A12 Homo sapiens (Human) TR40762_c0_g1_i1 Q14444 CAPR1_HUMAN 3.00E-51 GO:0003723; GO:0000932; GO:0010494; GO:0005829; GO:0030425; GO:0005887; GO:0017148; GO:0050775; GO:0061003 RNA binding; cytoplasmic mRNA processing body; cytoplasmic stress granule; cytosol; dendrite; integral to plasma membrane; negative regulation of translation; positive regulation of dendrite morphogenesis; positive regulation of dendritic spine morphogenesis IPR022070; Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 Homo sapiens (Human) TR40764_c0_g3_i1 Q9VUJ0 RM39_DROME 1.00E-92 GO:0031047; GO:0005762; GO:0000166; GO:0006417; GO:0003735; GO:0006412 gene silencing by RNA; mitochondrial large ribosomal subunit; nucleotide binding; regulation of translation; structural constituent of ribosome; translation IPR012675; IPR015552; IPR004095; IPR018163; "39S ribosomal protein L39, mitochondrial (MRP-L39) (MRP-L5)" mRpL39 mRpL5 CG17166 Drosophila melanogaster (Fruit fly) TR40765_c0_g1_i1 Q641W7 TTLL9_RAT 0 GO:0006464; GO:0005929; GO:0005737; GO:0016874; GO:0005874; GO:0005932 cellular protein modification process; cilium; cytoplasm; ligase activity; microtubule; microtubule basal body IPR004344; IPR027751; Probable tubulin polyglutamylase TTLL9 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 9) Ttll9 Rattus norvegicus (Rat) TR40765_c0_g1_i2 A4Q9E8 TTLL6_MOUSE 4.00E-50 GO:0036064; GO:0005737; GO:0016874; GO:0001578; GO:0051013; GO:0018095; GO:0015631 cilium basal body; cytoplasm; ligase activity; microtubule bundle formation; microtubule severing; protein polyglutamylation; tubulin binding IPR004344; IPR027754; Tubulin polyglutamylase TTLL6 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 6) Ttll6 Mus musculus (Mouse) TR40765_c0_g1_i5 Q23SI8 TTLL1_TETTS 5.00E-102 GO:0005929; GO:0000331; GO:0005874; GO:0005932; GO:0018095; GO:0070740 cilium; contractile vacuole; microtubule; microtubule basal body; protein polyglutamylation; tubulin-glutamic acid ligase activity IPR004344; Probable alpha-tubulin polyglutamylase Ttll1 (EC 6.-.-.-) (Tubulin-tyrosine ligase family protein 1) Ttll1 TTHERM_00136210 Tetrahymena thermophila (strain SB210) TR40765_c0_g1_i6 Q641W7 TTLL9_RAT 0 GO:0006464; GO:0005929; GO:0005737; GO:0016874; GO:0005874; GO:0005932 cellular protein modification process; cilium; cytoplasm; ligase activity; microtubule; microtubule basal body IPR004344; IPR027751; Probable tubulin polyglutamylase TTLL9 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 9) Ttll9 Rattus norvegicus (Rat) TR40766_c0_g1_i3 Q5R5M0 MTCH2_PONAB 3.00E-57 GO:0016021; GO:0005743; GO:0006810 integral to membrane; mitochondrial inner membrane; transport IPR018108; IPR023395; Mitochondrial carrier homolog 2 MTCH2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40767_c0_g2_i1 P55102 INHBA_HORSE 2.00E-06 GO:0000082; GO:0043509; GO:0032924; GO:0007050; GO:0005125; GO:0061029; GO:0040007; GO:0001942; GO:0002244; GO:0042541; GO:0043512; GO:0008584; GO:0030308; GO:0008285; GO:0042476; GO:0001541; GO:0060021; GO:0045648; GO:2001241; GO:0060279; GO:0045944; GO:0042701; GO:0046880; GO:0042493 G1/S transition of mitotic cell cycle; activin A complex; activin receptor signaling pathway; cell cycle arrest; cytokine activity; eyelid development in camera-type eye; growth; hair follicle development; hematopoietic progenitor cell differentiation; hemoglobin biosynthetic process; inhibin A complex; male gonad development; negative regulation of cell growth; negative regulation of cell proliferation; odontogenesis; ovarian follicle development; palate development; positive regulation of erythrocyte differentiation; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of ovulation; positive regulation of transcription from RNA polymerase II promoter; progesterone secretion; regulation of follicle-stimulating hormone secretion; response to drug IPR000491; IPR001839; IPR001111; IPR015615; IPR017948; Inhibin beta A chain (Activin beta-A chain) INHBA Equus caballus (Horse) TR40767_c6_g1_i1 O00139 KIF2A_HUMAN 2.00E-87 GO:0005524; GO:0019886; GO:0007596; GO:0030154; GO:0051301; GO:0005813; GO:0005829; GO:0005871; GO:0005874; GO:0003777; GO:0007018; GO:0007067; GO:0007052; GO:0003774; GO:0007399; GO:0000922 ATP binding; antigen processing and presentation of exogenous peptide antigen via MHC class II; blood coagulation; cell differentiation; cell division; centrosome; cytosol; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement; mitosis; mitotic spindle organization; motor activity; nervous system development; spindle pole IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF2A (Kinesin-2) (hK2) KIF2A KIF2 KNS2 Homo sapiens (Human) TR40767_c7_g1_i1 O04714 GCR1_ARATH 2.00E-10 GO:0004930; GO:0005794; GO:0009094; GO:0009738; GO:0007202; GO:0009785; GO:0009742; GO:0009736; GO:0009908; GO:0044214; GO:0009740; GO:0016021; GO:0006629; GO:0010231; GO:0000278; GO:0009788; GO:0005886; GO:0009939; GO:0032960; GO:0009735; GO:0010244; GO:0009845; GO:0006571; GO:0005774 P18064 G-protein coupled receptor activity; Golgi apparatus; L-phenylalanine biosynthetic process; abscisic acid mediated signaling pathway; activation of phospholipase C activity; blue light signaling pathway; brassinosteroid mediated signaling pathway; cytokinin mediated signaling pathway; flower development; fully spanning plasma membrane; gibberellic acid mediated signaling pathway; integral to membrane; lipid metabolic process; maintenance of seed dormancy; mitotic cell cycle; negative regulation of abscisic acid mediated signaling pathway; plasma membrane; positive regulation of gibberellic acid mediated signaling pathway; regulation of inositol trisphosphate biosynthetic process; response to cytokinin stimulus; response to low fluence blue light stimulus by blue low-fluence system; seed germination; tyrosine biosynthetic process; vacuolar membrane IPR022343; IPR017981; IPR022340; G-protein coupled receptor 1 GCR1 At1g48270 F11A17.17 Arabidopsis thaliana (Mouse-ear cress) TR40768_c0_g1_i1 Q96MF6 CQ10A_HUMAN 5.00E-66 GO:0005743 mitochondrial inner membrane IPR005031; IPR023393; "Coenzyme Q-binding protein COQ10 homolog A, mitochondrial" COQ10A UNQ6192/PRO20219 Homo sapiens (Human) TR40768_c0_g1_i2 Q6DFA6 CQ10A_XENLA 2.00E-63 GO:0005743 mitochondrial inner membrane IPR005031; IPR023393; "Coenzyme Q-binding protein COQ10 homolog A, mitochondrial" coq10b-a Xenopus laevis (African clawed frog) TR40769_c2_g1_i1 Q8CD19 LANC3_MOUSE 5.00E-114 GO:0003824; GO:0008152 catalytic activity; metabolic process IPR012341; IPR007822; IPR020464; LanC-like protein 3 Lancl3 Mus musculus (Mouse) TR40769_c2_g2_i1 Q86UC2 RSPH3_HUMAN 2.00E-93 IPR009290; Radial spoke head protein 3 homolog (Radial spoke head-like protein 2) RSPH3 RSHL2 RSP3 Homo sapiens (Human) TR4077_c0_g1_i1 Q8K0U4 HS12A_MOUSE 1.00E-23 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR40770_c2_g2_i1 Q43349 ROC2_ARATH 5.00E-06 GO:0003723; GO:0009507; GO:0006397; GO:0000166; GO:0030529 RNA binding; chloroplast; mRNA processing; nucleotide binding; ribonucleoprotein complex IPR012677; IPR000504; "29 kDa ribonucleoprotein, chloroplastic (RNA-binding protein cp29)" RBP29 At3g53460 F4P12_160 Arabidopsis thaliana (Mouse-ear cress) TR40770_c2_g2_i3 Q09167 SRSF5_RAT 1.00E-07 GO:0003723; GO:0008380; GO:0006397; GO:0016607; GO:0000166; GO:0051726; GO:0006355; GO:0009611; GO:0006351 "RNA binding; RNA splicing; mRNA processing; nuclear speck; nucleotide binding; regulation of cell cycle; regulation of transcription, DNA-dependent; response to wounding; transcription, DNA-dependent" IPR012677; IPR000504; "Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Insulin-induced growth response protein CL-4) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)" Srsf5 Cl-4 Hrs Sfrs5 Rattus norvegicus (Rat) TR40770_c2_g2_i5 Q6IQ97 RBM41_DANRE 2.00E-16 GO:0003723; GO:0000166; GO:0005634; GO:0008270 RNA binding; nucleotide binding; nucleus; zinc ion binding IPR012677; IPR000504; IPR001878; RNA-binding protein 4.1 (RNA-binding motif protein 4.1) rbm4.1 rbm4 Danio rerio (Zebrafish) (Brachydanio rerio) TR40772_c1_g3_i2 Q8VCA8 SCRN2_MOUSE 4.00E-87 GO:0016805; GO:0006508 dipeptidase activity; proteolysis IPR005322; Secernin-2 Scrn2 Mus musculus (Mouse) TR40772_c1_g3_i3 Q803W1 SCRN3_DANRE 2.00E-89 GO:0016805; GO:0006508 dipeptidase activity; proteolysis IPR005322; Secernin-3 scrn3 zgc:55430 Danio rerio (Zebrafish) (Brachydanio rerio) TR40773_c0_g1_i1 Q5T1B0 AXDN1_HUMAN 3.00E-59 IPR019347; Axonemal dynein light chain domain-containing protein 1 AXDND1 C1orf125 Homo sapiens (Human) TR40773_c0_g1_i3 Q5T1B0 AXDN1_HUMAN 3.00E-55 IPR019347; Axonemal dynein light chain domain-containing protein 1 AXDND1 C1orf125 Homo sapiens (Human) TR40773_c0_g2_i1 Q3UZ57 AXDN1_MOUSE 4.00E-25 IPR019347; Axonemal dynein light chain domain-containing protein 1 Axdnd1 Mus musculus (Mouse) TR40773_c0_g2_i3 Q95LP5 AXDN1_MACFA 1.00E-66 IPR019347; Axonemal dynein light chain domain-containing protein 1 AXDND1 QtsA-11085 QtsA-15492 QtsA-19166 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR40775_c0_g1_i1 Q6IV78 TAZ_SAISC 3.00E-87 GO:0016021; GO:0016746 "integral to membrane; transferase activity, transferring acyl groups" IPR002123; IPR000872; Tafazzin TAZ Saimiri sciureus (Common squirrel monkey) TR40775_c0_g1_i4 Q06510 TAZ1_YEAST 3.00E-22 GO:0047184; GO:0035965; GO:0007007; GO:0031307; GO:0042775; GO:0005743; GO:0005758; GO:0008654; GO:0006461 1-acylglycerophosphocholine O-acyltransferase activity; cardiolipin acyl-chain remodeling; inner mitochondrial membrane organization; integral to mitochondrial outer membrane; mitochondrial ATP synthesis coupled electron transport; mitochondrial inner membrane; mitochondrial intermembrane space; phospholipid biosynthetic process; protein complex assembly IPR002123; IPR000872; Lysophosphatidylcholine acyltransferase (EC 2.3.1.23) (1-acylglycerophosphocholine O-acyltransferase) (Tafazzin homolog) (lyso-PC acyltransferase) TAZ1 YPR140W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40775_c0_g1_i5 Q6IV78 TAZ_SAISC 2.00E-86 GO:0016021; GO:0016746 "integral to membrane; transferase activity, transferring acyl groups" IPR002123; IPR000872; Tafazzin TAZ Saimiri sciureus (Common squirrel monkey) TR40776_c3_g1_i1 Q8IVI9 NOSTN_HUMAN 4.00E-38 GO:0003677; GO:0005856; GO:0030666; GO:0006897; GO:0045892; GO:0046209; GO:0005634; GO:0005886; GO:0050999; GO:0007165; GO:0044281 Q05193; P11362; P29474; O08816 "DNA binding; cytoskeleton; endocytic vesicle membrane; endocytosis; negative regulation of transcription, DNA-dependent; nitric oxide metabolic process; nucleus; plasma membrane; regulation of nitric-oxide synthase activity; signal transduction; small molecule metabolic process" IPR001060; IPR011072; IPR001452; Nostrin (BM247 homolog) (Nitric oxide synthase traffic inducer) (Nitric oxide synthase trafficker) (eNOS-trafficking inducer) NOSTRIN Homo sapiens (Human) TR40776_c3_g1_i4 Q2KJB5 NOSTN_BOVIN 2.00E-14 GO:0016023; GO:0006897; GO:0005886; GO:0007165 cytoplasmic membrane-bounded vesicle; endocytosis; plasma membrane; signal transduction IPR001060; IPR011072; IPR001452; Nostrin (Nitric oxide synthase trafficker) (eNOS trafficking inducer) NOSTRIN Bos taurus (Bovine) TR40776_c3_g1_i5 P19878 NCF2_HUMAN 4.00E-09 GO:0043020; GO:0001669; GO:0007568; GO:0002479; GO:0006968; GO:0032870; GO:0005829; GO:0009055; GO:0045087; GO:0051701; GO:0005730; GO:0032010; GO:0090382; GO:0045777; GO:0043525; GO:0045730; GO:0014823; GO:0042493; GO:0009749; GO:0055093; GO:0034616; GO:0032496; GO:0032570; GO:0042554; GO:0016175 P04899; P62873; P14598; Q15080 "NADPH oxidase complex; acrosomal vesicle; aging; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cellular defense response; cellular response to hormone stimulus; cytosol; electron carrier activity; innate immune response; interaction with host; nucleolus; phagolysosome; phagosome maturation; positive regulation of blood pressure; positive regulation of neuron apoptotic process; respiratory burst; response to activity; response to drug; response to glucose stimulus; response to hyperoxia; response to laminar fluid shear stress; response to lipopolysaccharide; response to progesterone stimulus; superoxide anion generation; superoxide-generating NADPH oxidase activity" IPR000270; IPR000108; IPR001452; IPR013026; IPR011990; IPR001440; IPR019734; Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox) NCF2 NOXA2 P67PHOX Homo sapiens (Human) TR40777_c2_g1_i1 Q75WE7 VWA5A_RAT 1.00E-56 IPR013694; IPR002035; von Willebrand factor A domain-containing protein 5A (Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog) (Mast cell surface antigen 1) (Masa-1) Vwa5a Loh11cr2a Masa1 Rattus norvegicus (Rat) TR40777_c2_g4_i2 Q9UKK3 PARP4_HUMAN 4.00E-22 GO:0003677; GO:0006281; GO:0003950; GO:0008219; GO:0005737; GO:0019899; GO:0006954; GO:0005634; GO:0006471; GO:0042493; GO:0030529; GO:0005876; GO:0006810 Q9Q2G4 DNA binding; DNA repair; NAD+ ADP-ribosyltransferase activity; cell death; cytoplasm; enzyme binding; inflammatory response; nucleus; protein ADP-ribosylation; response to drug; ribonucleoprotein complex; spindle microtubule; transport IPR001357; IPR012317; IPR004102; IPR013694; IPR002035; Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) TR40777_c2_g4_i3 Q99KC8 VMA5A_MOUSE 3.00E-46 IPR013694; IPR002035; von Willebrand factor A domain-containing protein 5A (Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog) Vwa5a Loh11cr2a Mus musculus (Mouse) TR40778_c2_g3_i1 O13134 S4A4_AMBTI 6.00E-160 GO:0016323; GO:0005452; GO:0016021; GO:0006814; GO:0015293 basolateral plasma membrane; inorganic anion exchanger activity; integral to membrane; sodium ion transport; symporter activity IPR013769; IPR011531; IPR003020; IPR003024; IPR016152; Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) SLC4A4 NBC NBCE1 Ambystoma tigrinum (Eastern tiger salamander) TR40778_c2_g3_i3 O13134 S4A4_AMBTI 2.00E-92 GO:0016323; GO:0005452; GO:0016021; GO:0006814; GO:0015293 basolateral plasma membrane; inorganic anion exchanger activity; integral to membrane; sodium ion transport; symporter activity IPR013769; IPR011531; IPR003020; IPR003024; IPR016152; Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) SLC4A4 NBC NBCE1 Ambystoma tigrinum (Eastern tiger salamander) TR40779_c0_g3_i2 Q96BD0 SO4A1_HUMAN 6.00E-71 GO:0016021; GO:0005886; GO:0043252; GO:0055085; GO:0005215 integral to membrane; plasma membrane; sodium-independent organic anion transport; transmembrane transport; transporter activity IPR002350; IPR020846; IPR016196; IPR004156; Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) SLCO4A1 OATP1 OATP4A1 OATPE SLC21A12 Homo sapiens (Human) TR40779_c0_g3_i3 Q8K078 SO4A1_MOUSE 2.00E-71 GO:0016021; GO:0006811; GO:0005886; GO:0005215 integral to membrane; ion transport; plasma membrane; transporter activity IPR002350; IPR020846; IPR016196; IPR004156; Solute carrier organic anion transporter family member 4A1 (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) Slco4a1 Oatp4a1 Oatpe Slc21a12 Mus musculus (Mouse) TR40783_c2_g2_i2 Q924T7 RNF31_MOUSE 4.00E-116 GO:0035631; GO:0023035; GO:0071797; GO:0050852; GO:0005829; GO:0009898; GO:0043123; GO:0051092; GO:0097039; GO:0043130; GO:0004842; GO:0008270 O88522 CD40 receptor complex; CD40 signaling pathway; LUBAC complex; T cell receptor signaling pathway; cytosol; internal side of plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; protein linear polyubiquitination; ubiquitin binding; ubiquitin-protein ligase activity; zinc ion binding IPR018997; IPR026254; IPR015940; IPR002867; IPR001876; IPR017907; E3 ubiquitin-protein ligase RNF31 (EC 6.3.2.-) (HOIL-1-interacting protein) (HOIP) (Putative Ariadne-like ubiquitin ligase) (PAUL) (RING finger protein 31) Rnf31 Paul Mus musculus (Mouse) TR40783_c2_g2_i3 Q6T486 RBRA_DICDI 2.00E-10 GO:0016874; GO:0016567; GO:0030435; GO:0008270 ligase activity; protein ubiquitination; sporulation resulting in formation of a cellular spore; zinc ion binding IPR002867; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase rbrA (EC 6.3.2.-) (Ariadne-like ubiquitin ligase) rbrA DDB_G0286961 Dictyostelium discoideum (Slime mold) TR40784_c0_g1_i5 Q6GN91 NT5D3_XENLA 1.00E-164 GO:0016787; GO:0046872 hydrolase activity; metal ion binding IPR023214; IPR008380; IPR016695; 5'-nucleotidase domain-containing protein 3 (EC 3.1.3.-) nt5dc3 Xenopus laevis (African clawed frog) TR40785_c0_g1_i1 Q6L1R1 TBP_PICTO 2.00E-15 GO:0003677; GO:0006352; GO:0003700 "DNA binding; DNA-dependent transcription, initiation; sequence-specific DNA binding transcription factor activity" IPR012295; IPR000814; TATA-box-binding protein (Box A-binding protein) (BAP) (TATA sequence-binding protein) (TBP) (TATA-box factor) tbp PTO0506 Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) TR40785_c0_g1_i2 Q6DIY4 TBPL1_XENTR 3.00E-70 GO:0003677; GO:0006352; GO:0005737; GO:0009790; GO:0005634; GO:0006355; GO:0006366 "DNA binding; DNA-dependent transcription, initiation; cytoplasm; embryo development; nucleus; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter" IPR012295; IPR000814; TATA box-binding protein-like protein 1 (TBP-like protein 1) (TATA box-binding protein-related factor 2) (TBP-related factor 2) (TBP-like factor) tbpl1 tlf trf2 TEgg016a11.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40786_c0_g1_i1 Q9NZM1 MYOF_HUMAN 0 GO:0008015; GO:0005901; GO:0034605; GO:0031410; GO:0030659; GO:0070062; GO:0016021; GO:0006936; GO:0005635; GO:0031965; GO:0005543; GO:0001778; GO:0030947 blood circulation; caveola; cellular response to heat; cytoplasmic vesicle; cytoplasmic vesicle membrane; extracellular vesicular exosome; integral to membrane; muscle contraction; nuclear envelope; nuclear membrane; phospholipid binding; plasma membrane repair; regulation of vascular endothelial growth factor receptor signaling pathway IPR000008; IPR012968; IPR012560; IPR012561; IPR006614; Myoferlin (Fer-1-like protein 3) MYOF FER1L3 KIAA1207 Homo sapiens (Human) TR40786_c0_g1_i2 A0AVI2 FR1L5_HUMAN 8.00E-117 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR000008; IPR012968; IPR012560; IPR012561; IPR006614; Fer-1-like protein 5 FER1L5 Homo sapiens (Human) TR40786_c0_g1_i3 Q9ESD7 DYSF_MOUSE 7.00E-83 GO:0030315; GO:0031410; GO:0030659; GO:0016021; GO:0030027; GO:0001778; GO:0006906 T-tubule; cytoplasmic vesicle; cytoplasmic vesicle membrane; integral to membrane; lamellipodium; plasma membrane repair; vesicle fusion IPR000008; IPR012968; IPR012560; IPR012561; IPR010482; IPR006614; Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1) Dysf Fer1l1 Mus musculus (Mouse) TR40786_c0_g1_i4 Q9FVJ3 AGD12_ARATH 4.00E-06 GO:0008060; GO:0005794; GO:0006886; GO:0005543; GO:0005886; GO:0032312; GO:0005773; GO:0008270 ARF GTPase activator activity; Golgi apparatus; intracellular protein transport; phospholipid binding; plasma membrane; regulation of ARF GTPase activity; vacuole; zinc ion binding IPR001164; IPR000008; ADP-ribosylation factor GTPase-activating protein AGD12 (ARF GAP AGD12) (Protein ARF-GAP DOMAIN 12) (AtAGD12) (Zinc- and calcium-binding protein) (AtZAC) AGD12 ZAC At4g21160 F7J7.100 Arabidopsis thaliana (Mouse-ear cress) TR40788_c2_g1_i1 Q7Z6B7 SRGP1_HUMAN 2.00E-20 GO:0005100; GO:0007266; GO:0007411; GO:0016477; GO:0005829; GO:0051056; GO:0007264 Rho GTPase activator activity; Rho protein signal transduction; axon guidance; cell migration; cytosol; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR001060; IPR008936; IPR000198; IPR001452; SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) SRGAP1 ARHGAP13 KIAA1304 Homo sapiens (Human) TR40788_c2_g1_i3 Q5FWK3 RHG01_MOUSE 1.00E-116 GO:0030675; GO:0005737; GO:0005886; GO:0001726; GO:0007165 Rac GTPase activator activity; cytoplasm; plasma membrane; ruffle; signal transduction IPR001251; IPR008936; IPR000198; Rho GTPase-activating protein 1 (Rho-type GTPase-activating protein 1) Arhgap1 Mus musculus (Mouse) TR40789_c2_g1_i1 Q8L7J2 BGL06_ORYSJ 2.00E-99 GO:0033907; GO:0004565; GO:0080083; GO:0005975; GO:0080079; GO:0005576; GO:0042973; GO:0046872 "beta-D-fucosidase activity; beta-galactosidase activity; beta-gentiobiose beta-glucosidase activity; carbohydrate metabolic process; cellobiose glucosidase activity; extracellular region; glucan endo-1,3-beta-D-glucosidase activity; metal ion binding" IPR001360; IPR018120; IPR013781; IPR017853; Beta-glucosidase 6 (Os3bglu6) (EC 3.2.1.21) BGLU6 Os03g0212800 LOC_Os03g11420 Oryza sativa subsp. japonica (Rice) TR40789_c2_g1_i2 P29738 MYR2_SINAL 2.00E-20 GO:0005975; GO:0019137; GO:0005773 carbohydrate metabolic process; thioglucosidase activity; vacuole IPR001360; IPR018120; IPR013781; IPR017853; Myrosinase MB2 (EC 3.2.1.147) (Sinigrinase) (Thioglucosidase) (Fragment) Sinapis alba (White mustard) (Brassica hirta) TR40789_c2_g1_i3 P09849 LPH_RABIT 4.00E-128 GO:0016324; GO:0005975; GO:0017042; GO:0016021; GO:0000016 apical plasma membrane; carbohydrate metabolic process; glycosylceramidase activity; integral to membrane; lactase activity IPR001360; IPR018120; IPR013781; IPR017853; Lactase-phlorizin hydrolase (Lactase-glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Phlorizin hydrolase (EC 3.2.1.62)] LCT LPH Oryctolagus cuniculus (Rabbit) TR40789_c2_g1_i4 B7ECS8 BGL09_ORYSJ 5.00E-51 GO:0008422; GO:0005975 beta-glucosidase activity; carbohydrate metabolic process IPR001360; IPR018120; IPR013781; IPR017853; Putative beta-glucosidase 9 (Os4bglu9) (EC 3.2.1.21) BGLU9 Os04g0474300 LOC_Os04g39814 Oryza sativa subsp. japonica (Rice) TR40790_c0_g1_i1 Q9UBV2 SE1L1_HUMAN 0 GO:0007219; GO:0005789; GO:0016021; GO:0034976 Notch signaling pathway; endoplasmic reticulum membrane; integral to membrane; response to endoplasmic reticulum stress IPR000562; IPR013806; IPR006597; IPR011990; Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L) SEL1L TSA305 UNQ128/PRO1063 Homo sapiens (Human) TR40790_c0_g1_i2 Q5TEA6 SE1L2_HUMAN 8.00E-172 GO:0016021 integral to membrane IPR006597; IPR011990; Protein sel-1 homolog 2 (Suppressor of lin-12-like protein 2) (Sel-1L2) SEL1L2 C20orf50 Homo sapiens (Human) TR40790_c0_g1_i3 P77234 YBEQ_ECOLI 9.00E-22 IPR006597; IPR011990; Uncharacterized protein YbeQ ybeQ b0644 JW5091 Escherichia coli (strain K12) TR40790_c0_g2_i5 Q80Z70 SE1L1_RAT 5.00E-21 GO:0007219; GO:0005789; GO:0016021 Notch signaling pathway; endoplasmic reticulum membrane; integral to membrane IPR000562; IPR013806; IPR006597; IPR011990; Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L) Sel1l Sel1h Rattus norvegicus (Rat) TR40792_c1_g1_i1 C4JYM4 SEC11_UNCRE 1.00E-45 GO:0005789; GO:0016021; GO:0006508; GO:0008236; GO:0006465 endoplasmic reticulum membrane; integral to membrane; proteolysis; serine-type peptidase activity; signal peptide processing IPR019756; IPR028360; IPR019759; IPR015927; IPR001733; Signal peptidase complex catalytic subunit SEC11 (EC 3.4.21.89) (Signal peptidase I) SEC11 UREG_07275 Uncinocarpus reesii (strain UAMH 1704) TR40792_c1_g1_i2 Q9R0P6 SC11A_MOUSE 2.00E-102 GO:0005789; GO:0016021; GO:0006508; GO:0008236; GO:0006465 endoplasmic reticulum membrane; integral to membrane; proteolysis; serine-type peptidase activity; signal peptide processing IPR019758; IPR019756; IPR028360; IPR019759; IPR015927; IPR001733; Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18) (Sid 2895) Sec11a Sec11l1 Sid2895 Spc18 Mus musculus (Mouse) TR40792_c2_g2_i1 Q9U4L6 TO401_DROME 4.00E-62 GO:0071456; GO:0006811; GO:0005741; GO:0046930; GO:0015288; GO:0006626 cellular response to hypoxia; ion transport; mitochondrial outer membrane; pore complex; porin activity; protein targeting to mitochondrion IPR023614; IPR027246; Mitochondrial import receptor subunit TOM40 homolog 1 (dtom40) (Male sterile protein 15) (Translocase of outer membrane 40 kDa subunit homolog 1) Tom40 mit ms(1)15 CG12157 Drosophila melanogaster (Fruit fly) TR40792_c2_g3_i2 Q18090 TOM40_CAEEL 1.00E-29 GO:0006811; GO:0031966; GO:0005741; GO:0046930; GO:0015288; GO:0006626 ion transport; mitochondrial membrane; mitochondrial outer membrane; pore complex; porin activity; protein targeting to mitochondrion IPR023614; IPR027246; Mitochondrial import receptor subunit TOM40 homolog (Translocase of outer membrane 40 kDa subunit homolog) C18E9.6 Caenorhabditis elegans TR40793_c0_g1_i1 Q6UJY2 SL9C1_MOUSE 3.00E-63 GO:0030154; GO:0060170; GO:0016021; GO:0007275; GO:0006814; GO:0015299; GO:0030317; GO:0007283 cell differentiation; cilium membrane; integral to membrane; multicellular organismal development; sodium ion transport; solute:hydrogen antiporter activity; sperm motility; spermatogenesis IPR006153; IPR018422; IPR027359; IPR018490; IPR000595; IPR014710; Sodium/hydrogen exchanger 10 (Na(+)/H(+) exchanger 10) (NHE-10) (Solute carrier family 10 member 10) (Solute carrier family 9 member C1) (Sperm-specific Na(+)/H(+) exchanger) (sNHE) Slc9c1 Gm610 Slc9a10 Mus musculus (Mouse) TR40793_c0_g1_i3 Q5TAH2 SL9C2_HUMAN 2.00E-38 GO:0016021; GO:0006814; GO:0015299 integral to membrane; sodium ion transport; solute:hydrogen antiporter activity IPR006153; IPR018422; IPR027359; IPR018490; IPR000595; IPR014710; Sodium/hydrogen exchanger 11 (Na(+)/H(+) exchanger 11) (NHE-11) (Solute carrier family 9 member 11) (Solute carrier family 9 member C2) SLC9C2 SLC9A11 Homo sapiens (Human) TR40793_c0_g1_i4 Q3YL57 NHX8_ARATH 5.00E-39 GO:0016021; GO:0010352; GO:0010348; GO:0005886 integral to membrane; lithium ion export; lithium:hydrogen antiporter activity; plasma membrane IPR006153; IPR018422; IPR018418; Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Protein SALT OVERLY SENSITIVE 1B) NHX8 SOS1B At1g14660 F10B6.1 T5E21.14 Arabidopsis thaliana (Mouse-ear cress) TR40793_c0_g1_i5 Q6UJY2 SL9C1_MOUSE 9.00E-63 GO:0030154; GO:0060170; GO:0016021; GO:0007275; GO:0006814; GO:0015299; GO:0030317; GO:0007283 cell differentiation; cilium membrane; integral to membrane; multicellular organismal development; sodium ion transport; solute:hydrogen antiporter activity; sperm motility; spermatogenesis IPR006153; IPR018422; IPR027359; IPR018490; IPR000595; IPR014710; Sodium/hydrogen exchanger 10 (Na(+)/H(+) exchanger 10) (NHE-10) (Solute carrier family 10 member 10) (Solute carrier family 9 member C1) (Sperm-specific Na(+)/H(+) exchanger) (sNHE) Slc9c1 Gm610 Slc9a10 Mus musculus (Mouse) TR40793_c0_g3_i1 Q8RWU6 NHX6_ARATH 2.00E-12 GO:0032580; GO:0005768; GO:0010008; GO:0016021; GO:0006885; GO:0015385 Golgi cisterna membrane; endosome; endosome membrane; integral to membrane; regulation of pH; sodium:hydrogen antiporter activity IPR006153; IPR018422; IPR004709; Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) NHX6 At1g79610 F20B17.4 Arabidopsis thaliana (Mouse-ear cress) TR40794_c7_g1_i1 Q8BUG5 CAYP2_MOUSE 1.00E-31 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calcyphosin-2 (Calcyphosine-2) Caps2 Mus musculus (Mouse) TR40795_c5_g1_i1 O01393 UNC9_CAEEL 9.00E-70 GO:0005921; GO:0055077; GO:0016021; GO:0034220; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transmembrane transport; plasma membrane IPR000990; Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans TR40795_c5_g1_i4 O01393 UNC9_CAEEL 6.00E-70 GO:0005921; GO:0055077; GO:0016021; GO:0034220; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transmembrane transport; plasma membrane IPR000990; Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans TR40796_c0_g5_i1 O01761 UNC89_CAEEL 2.00E-60 GO:0005524; GO:0031430; GO:0005089; GO:0005543; GO:0004672; GO:0035023; GO:0030241 ATP binding; M band; Rho guanyl-nucleotide exchange factor activity; phospholipid binding; protein kinase activity; regulation of Rho protein signal transduction; skeletal muscle myosin thick filament assembly IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR007850; IPR001452; Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans TR40796_c0_g5_i2 O01761 UNC89_CAEEL 1.00E-62 GO:0005524; GO:0031430; GO:0005089; GO:0005543; GO:0004672; GO:0035023; GO:0030241 ATP binding; M band; Rho guanyl-nucleotide exchange factor activity; phospholipid binding; protein kinase activity; regulation of Rho protein signal transduction; skeletal muscle myosin thick filament assembly IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR007850; IPR001452; Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans TR408_c0_g1_i1 Q9H1K1 ISCU_HUMAN 2.00E-74 GO:0005829; GO:0005506; GO:0016226; GO:0051536; GO:0005759; GO:0009399; GO:0005634; GO:0032947; GO:0044281 cytosol; iron ion binding; iron-sulfur cluster assembly; iron-sulfur cluster binding; mitochondrial matrix; nitrogen fixation; nucleus; protein complex scaffold; small molecule metabolic process IPR011339; IPR002871; "Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (NifU-like N-terminal domain-containing protein) (NifU-like protein)" ISCU NIFUN Homo sapiens (Human) TR40800_c0_g2_i1 Q6GLZ8 SNR27_XENLA 2.00E-21 GO:0008380; GO:0006397; GO:0005634 RNA splicing; mRNA processing; nucleus IPR013957; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (U4/U6.U5 snRNP 27 kDa protein) (U4/U6.U5-27K) (U4/U6.U5 tri-snRNP-associated protein 3) snrnp27 Xenopus laevis (African clawed frog) TR40800_c0_g2_i2 Q8K194 SNR27_MOUSE 7.00E-23 GO:0008380; GO:0006397; GO:0005634 RNA splicing; mRNA processing; nucleus IPR013957; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (U4/U6.U5 snRNP 27 kDa protein) (U4/U6.U5-27K) (U4/U6.U5 tri-snRNP-associated protein 3) Snrnp27 Mus musculus (Mouse) TR40801_c0_g1_i1 Q5ZI58 F214A_CHICK 1.00E-47 IPR025261; Protein FAM214A FAM214A RCJMB04_30b20 Gallus gallus (Chicken) TR40801_c0_g1_i4 Q5ZI58 F214A_CHICK 2.00E-47 IPR025261; Protein FAM214A FAM214A RCJMB04_30b20 Gallus gallus (Chicken) TR40803_c0_g1_i1 Q3UCQ1 FOXK2_MOUSE 8.00E-120 GO:0008301; GO:0009790; GO:0000287; GO:0005634; GO:0007389; GO:0043565; GO:0003700; GO:0009888; GO:0006351 "DNA binding, bending; embryo development; magnesium ion binding; nucleus; pattern specification process; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; tissue development; transcription, DNA-dependent" IPR000253; IPR008984; IPR001766; IPR018122; IPR011991; Forkhead box protein K2 (Cellular transcription factor ILF-1) (Interleukin enhancer-binding factor 1) Foxk2 Ilf1 Mus musculus (Mouse) TR40803_c0_g1_i4 Q28F43 FOXN2_XENTR 2.00E-20 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; Forkhead box protein N2 foxn2 TGas051c08.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40803_c0_g1_i6 Q3UCQ1 FOXK2_MOUSE 1.00E-119 GO:0008301; GO:0009790; GO:0000287; GO:0005634; GO:0007389; GO:0043565; GO:0003700; GO:0009888; GO:0006351 "DNA binding, bending; embryo development; magnesium ion binding; nucleus; pattern specification process; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; tissue development; transcription, DNA-dependent" IPR000253; IPR008984; IPR001766; IPR018122; IPR011991; Forkhead box protein K2 (Cellular transcription factor ILF-1) (Interleukin enhancer-binding factor 1) Foxk2 Ilf1 Mus musculus (Mouse) TR40803_c0_g1_i7 Q3UCQ1 FOXK2_MOUSE 8.00E-120 GO:0008301; GO:0009790; GO:0000287; GO:0005634; GO:0007389; GO:0043565; GO:0003700; GO:0009888; GO:0006351 "DNA binding, bending; embryo development; magnesium ion binding; nucleus; pattern specification process; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; tissue development; transcription, DNA-dependent" IPR000253; IPR008984; IPR001766; IPR018122; IPR011991; Forkhead box protein K2 (Cellular transcription factor ILF-1) (Interleukin enhancer-binding factor 1) Foxk2 Ilf1 Mus musculus (Mouse) TR40804_c1_g3_i3 P55933 CKS1_PHYPO 1.00E-31 GO:0007049; GO:0051301; GO:0016538 cell cycle; cell division; cyclin-dependent protein serine/threonine kinase regulator activity IPR000789; Probable cyclin-dependent kinases regulatory subunit Physarum polycephalum (Slime mold) TR40804_c1_g3_i5 P55933 CKS1_PHYPO 5.00E-32 GO:0007049; GO:0051301; GO:0016538 cell cycle; cell division; cyclin-dependent protein serine/threonine kinase regulator activity IPR000789; Probable cyclin-dependent kinases regulatory subunit Physarum polycephalum (Slime mold) TR40805_c0_g1_i3 P31007 DLG1_DROME 3.00E-15 GO:0030714; GO:0045179; GO:0016327; GO:0045167; GO:0045175; GO:0016323; GO:0007155; GO:0060581; GO:0001708; GO:0005856; GO:0007391; GO:0005154; GO:0051294; GO:0045197; GO:0045196; GO:0016332; GO:0016336; GO:0042332; GO:0004385; GO:0016328; GO:0045475; GO:0008049; GO:0001738; GO:0008285; GO:0000122; GO:0031594; GO:0048471; GO:0007318; GO:0046956; GO:0045887; GO:0045211; GO:0046425; GO:0008593; GO:0030710; GO:0051726; GO:0042058; GO:0019991; GO:0004871; GO:0005920; GO:0005198; GO:0051124; GO:0061176 Q4AB30; Q9VE13 "anterior/posterior axis specification, follicular epithelium; apical cortex; apicolateral plasma membrane; asymmetric protein localization involved in cell fate determination; basal protein localization; basolateral plasma membrane; cell adhesion; cell fate commitment involved in pattern specification; cell fate specification; cytoskeleton; dorsal closure; epidermal growth factor receptor binding; establishment of spindle orientation; establishment or maintenance of epithelial cell apical/basal polarity; establishment or maintenance of neuroblast polarity; establishment or maintenance of polarity of embryonic epithelium; establishment or maintenance of polarity of larval imaginal disc epithelium; gravitaxis; guanylate kinase activity; lateral plasma membrane; locomotor rhythm; male courtship behavior; morphogenesis of a polarized epithelium; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; neuromuscular junction; perinuclear region of cytoplasm; pole plasm protein localization; positive phototaxis; positive regulation of synaptic growth at neuromuscular junction; postsynaptic membrane; regulation of JAK-STAT cascade; regulation of Notch signaling pathway; regulation of border follicle cell delamination; regulation of cell cycle; regulation of epidermal growth factor receptor signaling pathway; septate junction assembly; signal transducer activity; smooth septate junction; structural molecule activity; synaptic growth at neuromuscular junction; type Ib terminal bouton" IPR008145; IPR008144; IPR020590; IPR004172; IPR015143; IPR027417; IPR001478; IPR001452; Disks large 1 tumor suppressor protein dlg1 l(1)dlg1 CG1725 Drosophila melanogaster (Fruit fly) TR40805_c0_g1_i4 O88951 LIN7B_MOUSE 8.00E-92 GO:0016323; GO:0006887; GO:0043005; GO:0007269; GO:0005886; GO:0014069; GO:0045211; GO:0015031; GO:0005923 basolateral plasma membrane; exocytosis; neuron projection; neurotransmitter secretion; plasma membrane; postsynaptic density; postsynaptic membrane; protein transport; tight junction IPR004172; IPR014775; IPR017365; IPR001478; Protein lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) Lin7b Mals2 Veli2 Mus musculus (Mouse) TR40806_c4_g1_i1 Q06116 YP117_YEAST 1.00E-10 GO:0016021 integral to membrane IPR019443; IPR019409; IPR019441; IPR019415; IPR019449; Uncharacterized protein YPR117W YPR117W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40806_c7_g1_i1 Q14667 K0100_HUMAN 5.00E-159 GO:0005576 extracellular region IPR019443; IPR019441; IPR019439; UPF0378 protein KIAA0100 (Antigen MLAA-22) (Breast cancer-overexpressed gene 1 protein) KIAA0100 BCOX1 Homo sapiens (Human) TR40806_c7_g1_i2 Q14667 K0100_HUMAN 1.00E-15 GO:0005576 extracellular region IPR019443; IPR019441; IPR019439; UPF0378 protein KIAA0100 (Antigen MLAA-22) (Breast cancer-overexpressed gene 1 protein) KIAA0100 BCOX1 Homo sapiens (Human) TR40807_c1_g2_i1 P34102 PK3_DICDI 4.00E-80 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR000961; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Protein kinase 3 (PK3) (EC 2.7.11.1) pkgC DDB_G0286125 Dictyostelium discoideum (Slime mold) TR40807_c1_g2_i2 Q6IP76 AKT2B_XENLA 1.00E-104 GO:0005524; GO:0005938; GO:0032869; GO:0065002; GO:0005543; GO:0001934; GO:0090314; GO:0031340; GO:0004674; GO:0032587 ATP binding; cell cortex; cellular response to insulin stimulus; intracellular protein transmembrane transport; phospholipid binding; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of vesicle fusion; protein serine/threonine kinase activity; ruffle membrane IPR000961; IPR011009; IPR011993; IPR017892; IPR001849; IPR000719; IPR017441; IPR002290; IPR008271; "RAC-beta serine/threonine-protein kinase B (EC 2.7.11.1) (Protein kinase Akt-2-B) (Protein kinase B, beta-B) (PKB beta-B) (RAC-PK-beta-B)" akt2-b Xenopus laevis (African clawed frog) TR40807_c1_g2_i3 Q5R7A7 SGK3_PONAB 0 GO:0005524; GO:0007154; GO:0016023; GO:0005769; GO:0043066; GO:0035091; GO:0004674; GO:0055037 ATP binding; cell communication; cytoplasmic membrane-bounded vesicle; early endosome; negative regulation of apoptotic process; phosphatidylinositol binding; protein serine/threonine kinase activity; recycling endosome IPR000961; IPR011009; IPR001683; IPR017892; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) SGK3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40807_c1_g2_i4 Q755C4 IPL1_ASHGO 9.00E-44 GO:0005524; GO:0007049; GO:0007059; GO:0000777; GO:0005737; GO:0005634; GO:0004674; GO:0005819 ATP binding; cell cycle; chromosome segregation; condensed chromosome kinetochore; cytoplasm; nucleus; protein serine/threonine kinase activity; spindle IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora kinase) IPL1 AFL101C Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR40807_c1_g2_i5 Q5R7A7 SGK3_PONAB 0 GO:0005524; GO:0007154; GO:0016023; GO:0005769; GO:0043066; GO:0035091; GO:0004674; GO:0055037 ATP binding; cell communication; cytoplasmic membrane-bounded vesicle; early endosome; negative regulation of apoptotic process; phosphatidylinositol binding; protein serine/threonine kinase activity; recycling endosome IPR000961; IPR011009; IPR001683; IPR017892; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) SGK3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40807_c1_g2_i6 Q2PJ68 SGK1_CAEEL 6.00E-136 GO:0005524; GO:0005737; GO:0046872; GO:0007275; GO:0005634; GO:0004672; GO:0004674; GO:0006950 Q17941; Q9XTG7; O16850 ATP binding; cytoplasm; metal ion binding; multicellular organismal development; nucleus; protein kinase activity; protein serine/threonine kinase activity; response to stress IPR000961; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase sgk-1 (EC 2.7.11.1) (Serum- and glucocorticoid-inducible kinase homolog) (Serum/glucocorticoid-regulated kinase 1) sgk-1 W10G6.2 Caenorhabditis elegans TR40808_c3_g1_i1 P14217 ARS_CHLRE 5.00E-06 GO:0004065; GO:0046872; GO:0042597; GO:0018958; GO:0006950 arylsulfatase activity; metal ion binding; periplasmic space; phenol-containing compound metabolic process; response to stress IPR017849; IPR017850; IPR012083; IPR000917; IPR024607; Arylsulfatase (AS) (EC 3.1.6.1) (Aryl-sulfate sulphohydrolase) AS Chlamydomonas reinhardtii (Chlamydomonas smithii) TR40808_c3_g1_i10 P25549 ASLA_ECOLI 3.00E-40 GO:0004065; GO:0046872; GO:0042597 arylsulfatase activity; metal ion binding; periplasmic space IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase (AS) (EC 3.1.6.1) (Aryl-sulfate sulphohydrolase) aslA atsA b3801 JW3773 Escherichia coli (strain K12) TR40808_c3_g1_i11 Q148F3 ARSK_BOVIN 3.00E-08 GO:0005576; GO:0046872; GO:0008484 extracellular region; metal ion binding; sulfuric ester hydrolase activity IPR017849; IPR017850; IPR000917; Arylsulfatase K (ASK) (EC 3.1.6.-) ARSK Bos taurus (Bovine) TR40808_c3_g1_i2 P15848 ARSB_HUMAN 6.00E-122 GO:0005794; GO:0003943; GO:0004065; GO:0006914; GO:0005975; GO:0007417; GO:0030207; GO:0005788; GO:0006687; GO:0043202; GO:0007041; GO:0007040; GO:0046872; GO:0005739; GO:0043687; GO:0043627; GO:0051597; GO:0007584; GO:0009268; GO:0005791 Golgi apparatus; N-acetylgalactosamine-4-sulfatase activity; arylsulfatase activity; autophagy; carbohydrate metabolic process; central nervous system development; chondroitin sulfate catabolic process; endoplasmic reticulum lumen; glycosphingolipid metabolic process; lysosomal lumen; lysosomal transport; lysosome organization; metal ion binding; mitochondrion; post-translational protein modification; response to estrogen stimulus; response to methylmercury; response to nutrient; response to pH; rough endoplasmic reticulum IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) ARSB Homo sapiens (Human) TR40808_c3_g1_i3 Q32KJ9 ARSG_RAT 4.00E-31 GO:0004065; GO:0005783; GO:0005615; GO:0005764; GO:0046872; GO:0006790 arylsulfatase activity; endoplasmic reticulum; extracellular space; lysosome; metal ion binding; sulfur compound metabolic process IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase G (ASG) (EC 3.1.6.-) Arsg Rattus norvegicus (Rat) TR40808_c3_g1_i4 P50429 ARSB_MOUSE 2.00E-124 GO:0005794; GO:0003943; GO:0004065; GO:0006914; GO:0007417; GO:0005764; GO:0046872; GO:0005739; GO:0043627; GO:0051597; GO:0007584; GO:0009268; GO:0005791 Golgi apparatus; N-acetylgalactosamine-4-sulfatase activity; arylsulfatase activity; autophagy; central nervous system development; lysosome; metal ion binding; mitochondrion; response to estrogen stimulus; response to methylmercury; response to nutrient; response to pH; rough endoplasmic reticulum IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb As1 As1-s Mus musculus (Mouse) TR40808_c3_g1_i5 Q32KI9 ARSI_MOUSE 3.00E-114 GO:0005783; GO:0005576; GO:0046872; GO:0008484 endoplasmic reticulum; extracellular region; metal ion binding; sulfuric ester hydrolase activity IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase I (ASI) (EC 3.1.6.-) Arsi Mus musculus (Mouse) TR40808_c3_g1_i6 Q148F3 ARSK_BOVIN 2.00E-08 GO:0005576; GO:0046872; GO:0008484 extracellular region; metal ion binding; sulfuric ester hydrolase activity IPR017849; IPR017850; IPR000917; Arylsulfatase K (ASK) (EC 3.1.6.-) ARSK Bos taurus (Bovine) TR40808_c3_g1_i7 P50429 ARSB_MOUSE 1.00E-124 GO:0005794; GO:0003943; GO:0004065; GO:0006914; GO:0007417; GO:0005764; GO:0046872; GO:0005739; GO:0043627; GO:0051597; GO:0007584; GO:0009268; GO:0005791 Golgi apparatus; N-acetylgalactosamine-4-sulfatase activity; arylsulfatase activity; autophagy; central nervous system development; lysosome; metal ion binding; mitochondrion; response to estrogen stimulus; response to methylmercury; response to nutrient; response to pH; rough endoplasmic reticulum IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb As1 As1-s Mus musculus (Mouse) TR40808_c3_g1_i8 Q08CJ7 ARSK_DANRE 3.00E-06 GO:0005576; GO:0046872; GO:0008484 extracellular region; metal ion binding; sulfuric ester hydrolase activity IPR017849; IPR017850; IPR000917; Arylsulfatase K (ASK) (EC 3.1.6.-) arsk zgc:153019 Danio rerio (Zebrafish) (Brachydanio rerio) TR40809_c5_g1_i1 P58875 S14L2_BOVIN 2.00E-74 GO:0005737; GO:0016021; GO:0008289; GO:0005634; GO:0006355; GO:0006351; GO:0005215 "cytoplasm; integral to membrane; lipid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; transporter activity" IPR001071; IPR001251; IPR011074; IPR009038; SEC14-like protein 2 (Alpha-tocopherol-associated protein) (TAP) (bTAP) SEC14L2 Bos taurus (Bovine) TR40809_c6_g2_i2 P14408 FUMH_RAT 3.00E-156 GO:0004333; GO:0006106; GO:0006108; GO:0005739; GO:0006099; GO:0045239 fumarate hydratase activity; fumarate metabolic process; malate metabolic process; mitochondrion; tricarboxylic acid cycle; tricarboxylic acid cycle enzyme complex IPR005677; IPR024083; IPR018951; IPR020557; IPR000362; IPR022761; IPR008948; Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1. "Fumarate hydratase, mitochondrial (Fumarase) (EC 4.2.1.2)" Fh Fh1 Rattus norvegicus (Rat) TR40809_c6_g2_i3 B0T2T7 ARLY_CAUSK 3.00E-10 GO:0042450; GO:0004056; GO:0005737 arginine biosynthetic process via ornithine; argininosuccinate lyase activity; cytoplasm IPR009049; IPR024083; IPR020557; IPR000362; IPR022761; IPR008948; Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) argH Caul_3211 Caulobacter sp. (strain K31) TR40809_c6_g2_i5 O17214 FUMH_CAEEL 2.00E-163 GO:0004333; GO:0006106; GO:0005739; GO:0006099; GO:0045239 fumarate hydratase activity; fumarate metabolic process; mitochondrion; tricarboxylic acid cycle; tricarboxylic acid cycle enzyme complex IPR005677; IPR024083; IPR018951; IPR020557; IPR000362; IPR022761; IPR008948; Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1. "Probable fumarate hydratase, mitochondrial (Fumarase) (EC 4.2.1.2)" fum-1 H14A12.2 Caenorhabditis elegans TR40810_c2_g1_i1 Q0E587 MMP_SFAVA 2.00E-18 GO:0031012; GO:0004222; GO:0006508; GO:0008270 extracellular matrix; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR001818; IPR021190; IPR006026; Putative matrix metalloproteinase (EC 3.4.24.-) ORF14 Spodoptera frugiperda ascovirus 1a (SfAV-1a) TR40810_c2_g1_i2 P51512 MMP16_HUMAN 1.00E-45 GO:0005796; GO:0005509; GO:0009986; GO:0030574; GO:0008047; GO:0022617; GO:0005887; GO:0004222; GO:0005578; GO:0006508; GO:0008270 Golgi lumen; calcium ion binding; cell surface; collagen catabolic process; enzyme activator activity; extracellular matrix disassembly; integral to plasma membrane; metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000585; IPR018487; IPR018486; IPR024079; IPR001818; IPR021190; IPR021805; IPR016293; IPR021158; IPR006026; IPR002477; Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP) MMP16 MMPX2 Homo sapiens (Human) TR40810_c2_g1_i3 P22757 HE_PARLI 2.00E-50 GO:0031012; GO:0004222; GO:0006508; GO:0008270 extracellular matrix; metalloendopeptidase activity; proteolysis; zinc ion binding IPR000585; IPR018487; IPR024079; IPR001818; IPR021190; IPR021158; IPR006026; IPR002477; Hatching enzyme (HE) (HEZ) (EC 3.4.24.12) (Envelysin) (Sea-urchin-hatching proteinase) [Cleaved into: Hatching enzyme 18 kDa form] Paracentrotus lividus (Common sea urchin) TR40810_c2_g1_i4 P45452 MMP13_HUMAN 1.00E-48 GO:0030282; GO:0005509; GO:0051216; GO:0044267; GO:0030574; GO:0022617; GO:0005615; GO:0004222; GO:0005578; GO:0006508; GO:0008270 bone mineralization; calcium ion binding; cartilage development; cellular protein metabolic process; collagen catabolic process; extracellular matrix disassembly; extracellular space; metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000585; IPR018487; IPR018486; IPR024079; IPR001818; IPR021190; IPR016293; IPR021158; IPR006026; IPR002477; Collagenase 3 (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13) MMP13 Homo sapiens (Human) TR40810_c2_g1_i5 P22757 HE_PARLI 5.00E-52 GO:0031012; GO:0004222; GO:0006508; GO:0008270 extracellular matrix; metalloendopeptidase activity; proteolysis; zinc ion binding IPR000585; IPR018487; IPR024079; IPR001818; IPR021190; IPR021158; IPR006026; IPR002477; Hatching enzyme (HE) (HEZ) (EC 3.4.24.12) (Envelysin) (Sea-urchin-hatching proteinase) [Cleaved into: Hatching enzyme 18 kDa form] Paracentrotus lividus (Common sea urchin) TR40810_c3_g1_i1 Q80VM7 ANR24_MOUSE 2.00E-30 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 24 Ankrd24 Mus musculus (Mouse) TR40810_c3_g1_i2 Q8TF21 ANR24_HUMAN 1.00E-28 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 24 ANKRD24 KIAA1981 Homo sapiens (Human) TR40810_c3_g1_i3 Q9GL21 UACA_CANFA 4.00E-35 GO:0005737; GO:0005856; GO:0005634 cytoplasm; cytoskeleton; nucleus IPR002110; IPR020683; Uveal autoantigen with coiled-coil domains and ankyrin repeats UACA C3VS Canis familiaris (Dog) (Canis lupus familiaris) TR40810_c3_g1_i4 Q9VCA8 ANKHM_DROME 1.00E-21 GO:0003723; GO:0019730; GO:0051298; GO:0001751; GO:0005811; GO:0043066; GO:0046427; GO:0007169 RNA binding; antimicrobial humoral response; centrosome duplication; compound eye photoreceptor cell differentiation; lipid particle; negative regulation of apoptotic process; positive regulation of JAK-STAT cascade; transmembrane receptor protein tyrosine kinase signaling pathway IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) TR40810_c3_g1_i5 Q9GL21 UACA_CANFA 2.00E-35 GO:0005737; GO:0005856; GO:0005634 cytoplasm; cytoskeleton; nucleus IPR002110; IPR020683; Uveal autoantigen with coiled-coil domains and ankyrin repeats UACA C3VS Canis familiaris (Dog) (Canis lupus familiaris) TR40811_c0_g1_i1 Q9URY8 SULH2_SCHPO 2.00E-34 GO:0005794; GO:0016021; GO:0005886; GO:0008271; GO:0008272 Golgi apparatus; integral to membrane; plasma membrane; secondary active sulfate transmembrane transporter activity; sulfate transport IPR002645; IPR001902; IPR011547; Probable sulfate permease C869.05c SPAC869.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40811_c0_g2_i1 Q80ZD3 S2611_MOUSE 6.00E-75 GO:0005794; GO:0008509; GO:0015301; GO:0005783; GO:0016021; GO:0005765; GO:0005886; GO:0008271; GO:0008272 Golgi apparatus; anion transmembrane transporter activity; anion:anion antiporter activity; endoplasmic reticulum; integral to membrane; lysosomal membrane; plasma membrane; secondary active sulfate transmembrane transporter activity; sulfate transport IPR018045; IPR002645; IPR011547; Sodium-independent sulfate anion transporter (Solute carrier family 26 member 11) Slc26a11 Mus musculus (Mouse) TR40811_c0_g2_i3 Q62273 S26A2_MOUSE 2.00E-12 GO:0016021; GO:0001503; GO:0008271; GO:0008272 integral to membrane; ossification; secondary active sulfate transmembrane transporter activity; sulfate transport IPR018045; IPR002645; IPR001902; IPR011547; Sulfate transporter (Diastrophic dysplasia protein homolog) (ST-OB) (Solute carrier family 26 member 2) Slc26a2 Dtd Dtdst Mus musculus (Mouse) TR40811_c0_g2_i4 Q9FY46 SUT41_ARATH 6.00E-33 GO:0031969; GO:0016021; GO:0006950; GO:0008271; GO:0008272; GO:0015293 chloroplast membrane; integral to membrane; response to stress; secondary active sulfate transmembrane transporter activity; sulfate transport; symporter activity IPR018045; IPR002645; IPR001902; IPR011547; "Sulfate transporter 4.1, chloroplastic (AST82)" SULTR4;1 At5g13550 MSH12.1 T6I14_80 Arabidopsis thaliana (Mouse-ear cress) TR40811_c0_g2_i5 Q80ZD3 S2611_MOUSE 3.00E-75 GO:0005794; GO:0008509; GO:0015301; GO:0005783; GO:0016021; GO:0005765; GO:0005886; GO:0008271; GO:0008272 Golgi apparatus; anion transmembrane transporter activity; anion:anion antiporter activity; endoplasmic reticulum; integral to membrane; lysosomal membrane; plasma membrane; secondary active sulfate transmembrane transporter activity; sulfate transport IPR018045; IPR002645; IPR011547; Sodium-independent sulfate anion transporter (Solute carrier family 26 member 11) Slc26a11 Mus musculus (Mouse) TR40812_c1_g1_i1 Q27274 RO60_CAEEL 9.00E-27 GO:0003723; GO:0005737; GO:0046872; GO:0030529 RNA binding; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein homolog rop-1 C12D8.11 Caenorhabditis elegans TR40812_c1_g2_i2 P10155 RO60_HUMAN 2.00E-32 GO:0003723; GO:0060271; GO:0005737; GO:0046872; GO:0005634; GO:0030529; GO:0006383 Q9UHX1 RNA binding; cilium morphogenesis; cytoplasm; metal ion binding; nucleus; ribonucleoprotein complex; transcription from RNA polymerase III promoter IPR008858; IPR018698; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) TR40812_c1_g2_i4 O08848 RO60_MOUSE 1.00E-31 GO:0003723; GO:0060271; GO:0005737; GO:0046872; GO:0030529 RNA binding; cilium morphogenesis; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) Trove2 Ssa2 Mus musculus (Mouse) TR40812_c1_g3_i2 Q9RUW8 RO60_DEIRA 1.00E-28 GO:0003723; GO:0005737; GO:0046872; GO:0030529 RNA binding; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein homolog (Ro sixty-related protein) rsr DR_1262 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) TR40812_c1_g3_i3 P42700 RO60_XENLA 8.00E-75 GO:0003723; GO:0030030; GO:0005737; GO:0046872; GO:0030529 RNA binding; cell projection organization; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) trove2 Xenopus laevis (African clawed frog) TR40812_c1_g3_i5 Q27274 RO60_CAEEL 3.00E-46 GO:0003723; GO:0005737; GO:0046872; GO:0030529 RNA binding; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein homolog rop-1 C12D8.11 Caenorhabditis elegans TR40813_c7_g1_i1 Q6AY65 ARFP2_RAT 2.00E-86 GO:0030036; GO:0005938; GO:0001726 actin cytoskeleton organization; cell cortex; ruffle IPR027267; IPR010504; Arfaptin-2 (ADP-ribosylation factor-interacting protein 2) Arfip2 Rattus norvegicus (Rat) TR40813_c7_g1_i2 Q6AY65 ARFP2_RAT 2.00E-83 GO:0030036; GO:0005938; GO:0001726 actin cytoskeleton organization; cell cortex; ruffle IPR027267; IPR010504; Arfaptin-2 (ADP-ribosylation factor-interacting protein 2) Arfip2 Rattus norvegicus (Rat) TR40813_c8_g1_i1 Q9UTI2 GLRX2_SCHPO 4.00E-11 GO:0045454; GO:0009055; GO:0004602; GO:0004364; GO:0005739; GO:0015035; GO:0019430 cell redox homeostasis; electron carrier activity; glutathione peroxidase activity; glutathione transferase activity; mitochondrion; protein disulfide oxidoreductase activity; removal of superoxide radicals IPR011767; IPR002109; IPR011899; IPR014025; IPR012336; Glutaredoxin-2 grx2 SPAC15E1.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40813_c8_g1_i2 Q570Y9 DPTOR_MOUSE 2.00E-08 GO:0005622; GO:0035556; GO:0032007; GO:0045792; GO:0006469; GO:2001236 intracellular; intracellular signal transduction; negative regulation of TOR signaling cascade; negative regulation of cell size; negative regulation of protein kinase activity; regulation of extrinsic apoptotic signaling pathway IPR000591; IPR001478; IPR011991; DEP domain-containing mTOR-interacting protein (DEP domain-containing protein 6) Deptor Depdc6 Kiaa4200 Mus musculus (Mouse) TR40813_c8_g1_i3 Q9HU55 GLRX_PSEAE 2.00E-14 GO:0045454; GO:0005737; GO:0009055; GO:0006091; GO:0009117; GO:0015035 cell redox homeostasis; cytoplasm; electron carrier activity; generation of precursor metabolites and energy; nucleotide metabolic process; protein disulfide oxidoreductase activity IPR011767; IPR002109; IPR014025; IPR011900; IPR012336; Glutaredoxin grx PA5129 Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) TR40814_c6_g2_i1 Q9DA08 SGF29_MOUSE 1.00E-126 GO:0005671; GO:0070461; GO:0043966; GO:0035064; GO:0006355; GO:0006351 "Ada2/Gcn5/Ada3 transcription activator complex; SAGA-type complex; histone H3 acetylation; methylated histone residue binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR010750; SAGA-associated factor 29 homolog (Coiled-coil domain-containing protein 101) Ccdc101 Sgf29 Mus musculus (Mouse) TR40814_c6_g2_i3 Q96ES7 SGF29_HUMAN 2.00E-68 GO:0005671; GO:0070461; GO:0071169; GO:0043966; GO:0035064; GO:0006355; GO:0006351 P68431 "Ada2/Gcn5/Ada3 transcription activator complex; SAGA-type complex; establishment of protein localization to chromatin; histone H3 acetylation; methylated histone residue binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR010750; SAGA-associated factor 29 homolog (Coiled-coil domain-containing protein 101) CCDC101 SGF29 Homo sapiens (Human) TR40815_c1_g1_i1 Q3UJB9 EDC4_MOUSE 2.00E-106 GO:0000932; GO:0005634 Q4VGL6 cytoplasmic mRNA processing body; nucleus IPR015943; IPR001680; IPR017986; Enhancer of mRNA-decapping protein 4 Edc4 Mus musculus (Mouse) TR40815_c1_g2_i1 Q1LUT1 EDC4_DANRE 8.00E-47 GO:0000932; GO:0005634 cytoplasmic mRNA processing body; nucleus IPR015943; IPR001680; IPR017986; Enhancer of mRNA-decapping protein 4 edc4 si:dkey-16n13.6 Danio rerio (Zebrafish) (Brachydanio rerio) TR40816_c1_g1_i1 Q5EBF1 5NTC_XENTR 0 GO:0008253; GO:0005737; GO:0046872; GO:0000166; GO:0009117 5'-nucleotidase activity; cytoplasm; metal ion binding; nucleotide binding; nucleotide metabolic process IPR023214; IPR008380; IPR016695; Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (Cytosolic 5'-nucleotidase II) nt5c2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40819_c3_g2_i1 P53230 TAM41_YEAST 1.00E-33 GO:0032049; GO:0031314; GO:0005759; GO:0004605; GO:0015031 P19882 cardiolipin biosynthetic process; extrinsic to mitochondrial inner membrane; mitochondrial matrix; phosphatidate cytidylyltransferase activity; protein transport IPR015222; Mitochondrial translocator assembly and maintenance protein 41 (Mitochondrial import protein MMP37) (Mitochondrial matrix protein of 37 kDa) TAM41 MMP37 YGR046W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40819_c3_g2_i2 Q3B7H2 TAM41_DANRE 6.00E-100 GO:0031314; GO:0030150 extrinsic to mitochondrial inner membrane; protein import into mitochondrial matrix IPR015222; "Mitochondrial translocator assembly and maintenance protein 41 homolog (TAM41) (MMP37-like protein, mitochondrial)" tamm41 zgc:123195 Danio rerio (Zebrafish) (Brachydanio rerio) TR4082_c0_g2_i1 Q9CQM5 TXD17_MOUSE 2.00E-37 GO:0005829; GO:0009055; GO:0004601; GO:0047134; GO:0033209 cytosol; electron carrier activity; peroxidase activity; protein-disulfide reductase activity; tumor necrosis factor-mediated signaling pathway IPR010357; IPR012336; Thioredoxin domain-containing protein 17 (14 kDa thioredoxin-related protein) (TRP14) (Protein 42-9-9) (Thioredoxin-like protein 5) Txndc17 Txnl5 Mus musculus (Mouse) TR40821_c4_g1_i1 Q8R066 C1QT4_MOUSE 2.00E-09 GO:0005615 extracellular space IPR001073; IPR008983; Complement C1q tumor necrosis factor-related protein 4 C1qtnf4 Mus musculus (Mouse) TR40821_c4_g1_i3 Q4ZJM9 C1QL4_MOUSE 1.00E-06 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) TR40821_c4_g1_i5 Q8K482 EMIL2_MOUSE 2.00E-06 GO:0007155; GO:0005581 cell adhesion; collagen IPR001073; IPR011489; IPR008983; EMILIN-2 (Basilin) (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) Emilin2 Mus musculus (Mouse) TR40821_c4_g1_i6 P83425 HIP_MYTED 6.00E-10 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR40821_c4_g1_i8 Q8R066 C1QT4_MOUSE 3.00E-10 GO:0005615 extracellular space IPR001073; IPR008983; Complement C1q tumor necrosis factor-related protein 4 C1qtnf4 Mus musculus (Mouse) TR40822_c1_g1_i1 P0CR34 MKAR_CRYNJ 4.00E-08 GO:0005789; GO:0030497; GO:0016021; GO:0045703 endoplasmic reticulum membrane; fatty acid elongation; integral to membrane; ketoreductase activity IPR027533; IPR002198; IPR002347; IPR016040; IPR020904; Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (3-ketoacyl-CoA reductase) (3-ketoreductase) (KAR) (Microsomal beta-keto-reductase) CNI00690 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR40822_c1_g2_i1 Q8P3K4 FUCDH_XANCP 5.00E-23 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; 2-keto-3-deoxy-L-fuconate dehydrogenase (EC 1.1.1.-) XCC4067 Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568) TR40822_c1_g2_i3 Q7Z4W1 DCXR_HUMAN 7.00E-75 GO:0042732; GO:0050038; GO:0006739; GO:0005903; GO:0005881; GO:0006006; GO:0016020; GO:0005902; GO:0016655; GO:0051289; GO:0005997 "D-xylose metabolic process; L-xylulose reductase (NADP+) activity; NADP metabolic process; brush border; cytoplasmic microtubule; glucose metabolic process; membrane; microvillus; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; protein homotetramerization; xylulose metabolic process" IPR002198; IPR002347; IPR016040; IPR020904; L-xylulose reductase (XR) (EC 1.1.1.10) (Carbonyl reductase II) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Sperm surface protein P34H) DCXR Homo sapiens (Human) TR40822_c1_g2_i4 Q04520 BUDC_RAOTE 3.00E-17 GO:0045150; GO:0052588 acetoin catabolic process; diacetyl reductase ((S)-acetoin forming) activity IPR014007; IPR002198; IPR002347; IPR016040; IPR020904; "Diacetyl reductase [(S)-acetoin forming] (EC 1.1.1.304) (Acetoin(diacetyl) reductase) (AR) (Meso-2,3-butanediol dehydrogenase)" budC Raoultella terrigena (Klebsiella terrigena) TR40822_c1_g2_i6 Q17704 STDH3_CAEEL 1.00E-08 GO:0016491; GO:0006694 oxidoreductase activity; steroid biosynthetic process IPR002198; IPR002347; IPR016040; IPR020904; Putative steroid dehydrogenase 3 (EC 1.1.1.-) stdh-3 C06B3.5 Caenorhabditis elegans TR40822_c2_g1_i1 Q6NUE2 CBR4_XENLA 2.00E-28 GO:0006633; GO:0005759; GO:0016491 fatty acid biosynthetic process; mitochondrial matrix; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. Carbonyl reductase family member 4 (EC 1.-.-.-) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Quinone reductase CBR4) cbr4 Xenopus laevis (African clawed frog) TR40822_c2_g1_i10 Q91XV4 DCXR_MESAU 3.00E-68 GO:0042732; GO:0050038; GO:0001669; GO:0005881; GO:0006006; GO:0016020; GO:0051289; GO:0005997 D-xylose metabolic process; L-xylulose reductase (NADP+) activity; acrosomal vesicle; cytoplasmic microtubule; glucose metabolic process; membrane; protein homotetramerization; xylulose metabolic process IPR002198; IPR002347; IPR016040; IPR020904; L-xylulose reductase (XR) (EC 1.1.1.10) (Dicarbonyl/L-xylulose reductase) (Sperm antigen P26h) DCXR Mesocricetus auratus (Golden hamster) TR40822_c2_g1_i12 Q9P324 YI78_SCHPO 8.00E-13 GO:0005829; GO:0005634; GO:0016491 cytosol; nucleus; oxidoreductase activity IPR002198; IPR002347; IPR016040; Uncharacterized oxidoreductase C977.08/C1348.09 (EC 1.-.-.-) SPAC977.08; SPAC1348.09 SPBC1348.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40822_c2_g1_i13 P33368 YOHF_ECOLI 9.00E-30 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Uncharacterized oxidoreductase YohF (EC 1.-.-.-) yohF yohE b2137 JW2125 Escherichia coli (strain K12) TR40822_c2_g1_i4 P14802 YOXD_BACSU 5.00E-22 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Uncharacterized oxidoreductase YoxD (EC 1.-.-.-) yoxD BSU18500 Bacillus subtilis (strain 168) TR40822_c2_g1_i6 P73574 FABG1_SYNY3 3.00E-22 GO:0004316; GO:0051287; GO:0006633 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NAD binding; fatty acid biosynthetic process IPR011284; IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. 3-oxoacyl-[acyl-carrier-protein] reductase 1 (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase 1) fabG1 slr0886 Synechocystis sp. (strain PCC 6803 / Kazusa) TR40822_c2_g1_i7 Q04520 BUDC_RAOTE 4.00E-13 GO:0045150; GO:0052588 acetoin catabolic process; diacetyl reductase ((S)-acetoin forming) activity IPR014007; IPR002198; IPR002347; IPR016040; IPR020904; "Diacetyl reductase [(S)-acetoin forming] (EC 1.1.1.304) (Acetoin(diacetyl) reductase) (AR) (Meso-2,3-butanediol dehydrogenase)" budC Raoultella terrigena (Klebsiella terrigena) TR40822_c2_g1_i8 Q6NUE2 CBR4_XENLA 2.00E-29 GO:0006633; GO:0005759; GO:0016491 fatty acid biosynthetic process; mitochondrial matrix; oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. Carbonyl reductase family member 4 (EC 1.-.-.-) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Quinone reductase CBR4) cbr4 Xenopus laevis (African clawed frog) TR40822_c2_g1_i9 Q49117 Y182_METEA 4.00E-28 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Uncharacterized oxidoreductase MexAM1_META1p0182 (EC 1.-.-.-) (ORFC) MexAM1_META1p0182 Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1) TR40823_c1_g3_i1 P20905 5HT1R_DROME 3.00E-47 GO:0007192; GO:0004952; GO:0007212; GO:0060180; GO:0016021; GO:0005887; GO:0016543; GO:0016546; GO:0016545; GO:0004993 "adenylate cyclase-activating serotonin receptor signaling pathway; dopamine neurotransmitter receptor activity; dopamine receptor signaling pathway; female mating behavior; integral to membrane; integral to plasma membrane; male courtship behavior, orientation prior to leg tapping and wing vibration; male courtship behavior, proboscis-mediated licking; male courtship behavior, veined wing vibration; serotonin receptor activity" IPR000929; IPR000276; IPR017452; 5-hydroxytryptamine receptor 1 (5-HT receptor) (5HT-dro) (Serotonin receptor 1) 5-HT7 5HT-R1 CG12073 Drosophila melanogaster (Fruit fly) TR40823_c1_g3_i10 P20905 5HT1R_DROME 7.00E-83 GO:0007192; GO:0004952; GO:0007212; GO:0060180; GO:0016021; GO:0005887; GO:0016543; GO:0016546; GO:0016545; GO:0004993 "adenylate cyclase-activating serotonin receptor signaling pathway; dopamine neurotransmitter receptor activity; dopamine receptor signaling pathway; female mating behavior; integral to membrane; integral to plasma membrane; male courtship behavior, orientation prior to leg tapping and wing vibration; male courtship behavior, proboscis-mediated licking; male courtship behavior, veined wing vibration; serotonin receptor activity" IPR000929; IPR000276; IPR017452; 5-hydroxytryptamine receptor 1 (5-HT receptor) (5HT-dro) (Serotonin receptor 1) 5-HT7 5HT-R1 CG12073 Drosophila melanogaster (Fruit fly) TR40823_c1_g3_i2 P20905 5HT1R_DROME 7.00E-83 GO:0007192; GO:0004952; GO:0007212; GO:0060180; GO:0016021; GO:0005887; GO:0016543; GO:0016546; GO:0016545; GO:0004993 "adenylate cyclase-activating serotonin receptor signaling pathway; dopamine neurotransmitter receptor activity; dopamine receptor signaling pathway; female mating behavior; integral to membrane; integral to plasma membrane; male courtship behavior, orientation prior to leg tapping and wing vibration; male courtship behavior, proboscis-mediated licking; male courtship behavior, veined wing vibration; serotonin receptor activity" IPR000929; IPR000276; IPR017452; 5-hydroxytryptamine receptor 1 (5-HT receptor) (5HT-dro) (Serotonin receptor 1) 5-HT7 5HT-R1 CG12073 Drosophila melanogaster (Fruit fly) TR40823_c1_g3_i3 Q91559 5HT7R_XENLA 5.00E-61 GO:0007623; GO:0005887; GO:0004993; GO:0007210; GO:0006939; GO:0007268; GO:0042310 circadian rhythm; integral to plasma membrane; serotonin receptor activity; serotonin receptor signaling pathway; smooth muscle contraction; synaptic transmission; vasoconstriction IPR001069; IPR002231; IPR000276; IPR017452; 5-hydroxytryptamine receptor 7 (5-HT-7) (5-HT7) (Serotonin receptor 7) htr7 5ht7 Xenopus laevis (African clawed frog) TR40823_c1_g3_i5 O42385 5H1AA_TAKRU 1.00E-70 GO:0007198; GO:0007610; GO:0008283; GO:0005887; GO:0050795; GO:0046883; GO:0004993; GO:0042310 adenylate cyclase-inhibiting serotonin receptor signaling pathway; behavior; cell proliferation; integral to plasma membrane; regulation of behavior; regulation of hormone secretion; serotonin receptor activity; vasoconstriction IPR000610; IPR002231; IPR000276; IPR017452; 5-hydroxytryptamine receptor 1A-alpha (5-HT-1A-alpha) (5-HT1A-alpha) (F1A) (Serotonin receptor 1A-alpha) htr1aa Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR40823_c1_g3_i6 Q91559 5HT7R_XENLA 5.00E-61 GO:0007623; GO:0005887; GO:0004993; GO:0007210; GO:0006939; GO:0007268; GO:0042310 circadian rhythm; integral to plasma membrane; serotonin receptor activity; serotonin receptor signaling pathway; smooth muscle contraction; synaptic transmission; vasoconstriction IPR001069; IPR002231; IPR000276; IPR017452; 5-hydroxytryptamine receptor 7 (5-HT-7) (5-HT7) (Serotonin receptor 7) htr7 5ht7 Xenopus laevis (African clawed frog) TR40823_c1_g3_i7 P20905 5HT1R_DROME 7.00E-83 GO:0007192; GO:0004952; GO:0007212; GO:0060180; GO:0016021; GO:0005887; GO:0016543; GO:0016546; GO:0016545; GO:0004993 "adenylate cyclase-activating serotonin receptor signaling pathway; dopamine neurotransmitter receptor activity; dopamine receptor signaling pathway; female mating behavior; integral to membrane; integral to plasma membrane; male courtship behavior, orientation prior to leg tapping and wing vibration; male courtship behavior, proboscis-mediated licking; male courtship behavior, veined wing vibration; serotonin receptor activity" IPR000929; IPR000276; IPR017452; 5-hydroxytryptamine receptor 1 (5-HT receptor) (5HT-dro) (Serotonin receptor 1) 5-HT7 5HT-R1 CG12073 Drosophila melanogaster (Fruit fly) TR40823_c1_g3_i9 Q91559 5HT7R_XENLA 5.00E-61 GO:0007623; GO:0005887; GO:0004993; GO:0007210; GO:0006939; GO:0007268; GO:0042310 circadian rhythm; integral to plasma membrane; serotonin receptor activity; serotonin receptor signaling pathway; smooth muscle contraction; synaptic transmission; vasoconstriction IPR001069; IPR002231; IPR000276; IPR017452; 5-hydroxytryptamine receptor 7 (5-HT-7) (5-HT7) (Serotonin receptor 7) htr7 5ht7 Xenopus laevis (African clawed frog) TR40824_c1_g1_i16 Q9NUV9 GIMA4_HUMAN 8.00E-32 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR40824_c1_g1_i17 Q99JY3 GIMA4_MOUSE 8.00E-23 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Mus musculus (Mouse) TR40824_c1_g1_i18 Q75N62 GIMA8_MOUSE 7.00E-18 GO:0005525; GO:0005794; GO:0005829; GO:0005783; GO:0005739; GO:0005634 GTP binding; Golgi apparatus; cytosol; endoplasmic reticulum; mitochondrion; nucleus IPR006703; IPR027417; GTPase IMAP family member 8 (mGIMAP8) (Immune-associated nucleotide-binding protein 9) (IAN-9) (Immunity-associated protein 8) Gimap8 Ian9 Imap8 Mus musculus (Mouse) TR40824_c1_g1_i19 E9PW74 GIMD1_MOUSE 2.00E-09 GO:0005525 GTP binding IPR006703; IPR027417; GTPase IMAP family member GIMD1 (GIMAP family P-loop NTPase domain-containing protein 1) Gimd1 Gm5549 Mus musculus (Mouse) TR40824_c1_g1_i3 Q8NHV1 GIMA7_HUMAN 1.00E-34 GO:0005525; GO:0003924; GO:0005811 GTP binding; GTPase activity; lipid particle IPR006703; IPR027417; GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) TR40826_c0_g1_i1 Q8C525 M21D2_MOUSE 8.00E-10 IPR024810; IPR024803; Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) TR40827_c3_g1_i1 Q9H8W5 TRI45_HUMAN 1.00E-07 GO:0060348; GO:0005737; GO:0005634; GO:0008270 bone development; cytoplasm; nucleus; zinc ion binding IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) TR40827_c3_g1_i2 Q5BIM1 TRI45_BOVIN 2.00E-06 GO:0005737; GO:0005634; GO:0008270 cytoplasm; nucleus; zinc ion binding IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) TR40827_c4_g1_i1 Q95332 BHMT1_PIG 6.00E-18 GO:0006579; GO:0047150; GO:0005737; GO:0008898; GO:0009086; GO:0008270 amino-acid betaine catabolic process; betaine-homocysteine S-methyltransferase activity; cytoplasm; homocysteine S-methyltransferase activity; methionine biosynthetic process; zinc ion binding IPR017226; IPR003726; Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. Betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5) (Fragment) BHMT Sus scrofa (Pig) TR40828_c0_g3_i1 Q0P6H9 TMM62_HUMAN 1.00E-41 GO:0016021 integral to membrane Transmembrane protein 62 TMEM62 Homo sapiens (Human) TR40828_c0_g5_i3 Q9P055 JKAMP_HUMAN 7.00E-75 GO:0030433; GO:0005789; GO:0016021; GO:0006986 ER-associated protein catabolic process; endoplasmic reticulum membrane; integral to membrane; response to unfolded protein IPR008485; JNK1/MAPK8-associated membrane protein (JKAMP) (JNK1-associated membrane protein) (JAMP) (Medulloblastoma antigen MU-MB-50.4) JKAMP C14orf100 JAMP CDA06 HSPC213 HSPC327 Homo sapiens (Human) TR40830_c0_g1_i1 Q54RM0 EAF3_DICDI 2.00E-07 GO:0006281; GO:0016568; GO:0005634; GO:0040008; GO:0006355; GO:0006351 "DNA repair; chromatin modification; nucleus; regulation of growth; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000953; IPR016197; IPR008676; IPR026541; IPR025995; NuA4 complex subunit EAF3 homolog DDB_G0283075 Dictyostelium discoideum (Slime mold) TR40830_c0_g2_i1 Q5R6Y9 MS3L1_PONAB 2.00E-28 GO:0003677; GO:0072487; GO:0043984; GO:0035064; GO:0006355; GO:0006351 "DNA binding; MSL complex; histone H4-K16 acetylation; methylated histone residue binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000953; IPR016197; IPR008676; IPR026541; IPR025995; Male-specific lethal 3 homolog (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) MSL3 MSL3L1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40831_c0_g1_i1 Q17QZ7 TTC27_BOVIN 8.00E-136 IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 27 (TPR repeat protein 27) TTC27 Bos taurus (Bovine) TR40832_c4_g1_i1 Q9NZJ4 SACS_HUMAN 1.00E-28 GO:0005524; GO:0030424; GO:0070852; GO:0008219; GO:0051087; GO:0030425; GO:0005739; GO:0090084; GO:0005634; GO:0006457 ATP binding; axon; cell body fiber; cell death; chaperone binding; dendrite; mitochondrion; negative regulation of inclusion body assembly; nucleus; protein folding IPR001623; IPR003594; IPR007842; IPR000626; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) TR40832_c5_g1_i1 Q9JLC8 SACS_MOUSE 1.00E-06 GO:0005524; GO:0050750; GO:0005739; GO:0090084; GO:0005634 ATP binding; low-density lipoprotein particle receptor binding; mitochondrion; negative regulation of inclusion body assembly; nucleus IPR001623; IPR003594; IPR007842; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) TR40834_c0_g1_i1 O43592 XPOT_HUMAN 0 GO:0005737; GO:0006886; GO:0005654; GO:0000049; GO:0006409 cytoplasm; intracellular protein transport; nucleoplasm; tRNA binding; tRNA export from nucleus IPR011989; IPR016024; IPR013598; IPR001494; Exportin-T (Exportin(tRNA)) (tRNA exportin) XPOT Homo sapiens (Human) TR40834_c0_g1_i2 Q54RI9 XPOT_DICDI 7.00E-66 GO:0005829; GO:0005635; GO:0000049; GO:0006409 cytosol; nuclear envelope; tRNA binding; tRNA export from nucleus IPR011989; IPR016024; IPR013598; Exportin-T (Exportin(tRNA)) (tRNA exportin) xpot DDB_G0283119 Dictyostelium discoideum (Slime mold) TR40834_c0_g1_i3 Q4PC84 XPOT_USTMA 2.00E-82 GO:0005737; GO:0005634; GO:0000049; GO:0008033; GO:0006810 cytoplasm; nucleus; tRNA binding; tRNA processing; transport IPR011989; IPR016024; IPR013598; Exportin-T (Exportin(tRNA)) (Karyopherin-beta) (tRNA exportin) LOS1 UM02279 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR40835_c3_g1_i1 Q2KIQ4 COQ2_BOVIN 5.00E-104 GO:0002083; GO:0047293; GO:0016021; GO:0008299; GO:0031966; GO:0006744 4-hydroxybenzoate decaprenyltransferase activity; 4-hydroxybenzoate nonaprenyltransferase activity; integral to membrane; isoprenoid biosynthetic process; mitochondrial membrane; ubiquinone biosynthetic process IPR006370; IPR000537; Cofactor biosynthesis; ubiquinone biosynthesis. "4-hydroxybenzoate polyprenyltransferase, mitochondrial (EC 2.5.1.39) (Para-hydroxybenzoate--polyprenyltransferase) (PHB:polyprenyltransferase)" COQ2 Bos taurus (Bovine) TR40835_c3_g1_i2 Q31DM4 UBIA_THICR 4.00E-44 GO:0016021; GO:0005886; GO:0004659; GO:0006744 integral to membrane; plasma membrane; prenyltransferase activity; ubiquinone biosynthetic process IPR006370; IPR000537; Cofactor biosynthesis; ubiquinone biosynthesis. 4-hydroxybenzoate octaprenyltransferase (EC 2.5.1.-) (4-HB polyprenyltransferase) ubiA Tcr_2161 Thiomicrospira crunogena (strain XCL-2) TR40835_c3_g1_i4 Q2KIQ4 COQ2_BOVIN 2.00E-108 GO:0002083; GO:0047293; GO:0016021; GO:0008299; GO:0031966; GO:0006744 4-hydroxybenzoate decaprenyltransferase activity; 4-hydroxybenzoate nonaprenyltransferase activity; integral to membrane; isoprenoid biosynthetic process; mitochondrial membrane; ubiquinone biosynthetic process IPR006370; IPR000537; Cofactor biosynthesis; ubiquinone biosynthesis. "4-hydroxybenzoate polyprenyltransferase, mitochondrial (EC 2.5.1.39) (Para-hydroxybenzoate--polyprenyltransferase) (PHB:polyprenyltransferase)" COQ2 Bos taurus (Bovine) TR40837_c0_g1_i1 P16423 POLR_DROME 1.00E-14 GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0046872; GO:0090305; GO:0006508 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR000477; IPR007087; IPR015880; Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM (Retrovirus-related Pol polyprotein from type II retrotransposable element R2DM) [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR40837_c0_g2_i1 P21329 RTJK_DROFU 5.00E-11 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) TR40837_c4_g2_i1 Q6DGP2 SYF2_DANRE 2.00E-79 GO:0008380; GO:0006397; GO:0005634 RNA splicing; mRNA processing; nucleus IPR013260; Pre-mRNA-splicing factor syf2 syf2 zgc:92835 Danio rerio (Zebrafish) (Brachydanio rerio) TR40838_c3_g1_i1 Q8C581 TMM91_MOUSE 5.00E-07 GO:0016021; GO:0009607 integral to membrane; response to biotic stimulus IPR007593; Transmembrane protein 91 (Dispanin subfamily C member 3) (DSPC3) (Synapse differentiation-induced protein 3) Tmem91 SynDIG3 Mus musculus (Mouse) TR40838_c3_g1_i4 Q6MG82 PRRT1_RAT 4.00E-11 GO:0030054; GO:0016021; GO:0005886; GO:0009607; GO:0045202 cell junction; integral to membrane; plasma membrane; response to biotic stimulus; synapse IPR007593; Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) Prrt1 Ng5 Rattus norvegicus (Rat) TR40838_c3_g1_i8 Q6MG82 PRRT1_RAT 1.00E-11 GO:0030054; GO:0016021; GO:0005886; GO:0009607; GO:0045202 cell junction; integral to membrane; plasma membrane; response to biotic stimulus; synapse IPR007593; Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) Prrt1 Ng5 Rattus norvegicus (Rat) TR40839_c0_g1_i2 P54612 2AAA_PIG 0 GO:0003823; GO:0007059; GO:0000775; GO:0005829; GO:0070262; GO:0000159; GO:0004722; GO:0042981 "antigen binding; chromosome segregation; chromosome, centromeric region; cytosol; peptidyl-serine dephosphorylation; protein phosphatase type 2A complex; protein serine/threonine phosphatase activity; regulation of apoptotic process" IPR011989; IPR016024; IPR000357; IPR021133; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) PPP2R1A Sus scrofa (Pig) TR40839_c0_g1_i4 Q54QR9 2AAA_DICDI 0 GO:0005813; GO:0005829; GO:0031034; GO:0005634; GO:0000159 centrosome; cytosol; myosin filament assembly; nucleus; protein phosphatase type 2A complex IPR011989; IPR016024; IPR000357; IPR021133; Serine/threonine-protein phosphatase 2A regulatory subunit pppA (Protein phosphatase 2A 65 kDa regulatory subunit) (Protein phosphatase 2A A subunit) (Protein phosphatase 2A scaffold subunit) pppA rcdB veg124 DDB_G0283601 Dictyostelium discoideum (Slime mold) TR40839_c0_g1_i7 P54612 2AAA_PIG 0 GO:0003823; GO:0007059; GO:0000775; GO:0005829; GO:0070262; GO:0000159; GO:0004722; GO:0042981 "antigen binding; chromosome segregation; chromosome, centromeric region; cytosol; peptidyl-serine dephosphorylation; protein phosphatase type 2A complex; protein serine/threonine phosphatase activity; regulation of apoptotic process" IPR011989; IPR016024; IPR000357; IPR021133; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) PPP2R1A Sus scrofa (Pig) TR40841_c0_g1_i2 Q8AY73 XPO2_ORENI 0 GO:0005737; GO:0006886; GO:0005634 cytoplasm; intracellular protein transport; nucleus IPR011989; IPR016024; IPR005043; IPR013713; IPR001494; Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter) cse1l cas xpo2 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) TR40841_c0_g1_i3 Q8AY73 XPO2_ORENI 0 GO:0005737; GO:0006886; GO:0005634 cytoplasm; intracellular protein transport; nucleus IPR011989; IPR016024; IPR005043; IPR013713; IPR001494; Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter) cse1l cas xpo2 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) TR40844_c0_g1_i2 O45731 YFC7_CAEEL 1.00E-27 GO:0016021 integral to membrane IPR002995; Uncharacterized protein T02E1.7 T02E1.7 Caenorhabditis elegans TR40844_c0_g1_i3 P53337 ERV29_YEAST 1.00E-28 GO:0030134; GO:0006888; GO:0005789; GO:0016021 P38353 ER to Golgi transport vesicle; ER to Golgi vesicle-mediated transport; endoplasmic reticulum membrane; integral to membrane IPR002995; ER-derived vesicles protein ERV29 ERV29 YGR284C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40844_c0_g1_i4 O57590 SURF4_TAKRU 3.00E-114 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR002995; Surfeit locus protein 4 surf4 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR40844_c0_g1_i5 O57590 SURF4_TAKRU 2.00E-117 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR002995; Surfeit locus protein 4 surf4 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR40846_c3_g1_i1 D4A6L0 GP158_RAT 1.00E-12 GO:0004930; GO:0016021; GO:0005886; GO:0072659; GO:0008277 G-protein coupled receptor activity; integral to membrane; plasma membrane; protein localization to plasma membrane; regulation of G-protein coupled receptor protein signaling pathway IPR017978; Probable G-protein coupled receptor 158 Gpr158 Rattus norvegicus (Rat) TR40846_c3_g1_i8 Q5T848 GP158_HUMAN 2.00E-14 GO:0004930; GO:0016021; GO:0005886; GO:0072659; GO:0008277 G-protein coupled receptor activity; integral to membrane; plasma membrane; protein localization to plasma membrane; regulation of G-protein coupled receptor protein signaling pathway IPR017978; Probable G-protein coupled receptor 158 GPR158 KIAA1136 Homo sapiens (Human) TR40847_c0_g1_i2 Q66KY3 CUTA_XENLA 1.00E-39 GO:0010038 response to metal ion IPR004323; IPR011322; Protein CutA homolog cuta Xenopus laevis (African clawed frog) TR40847_c0_g1_i4 Q66KY3 CUTA_XENLA 1.00E-39 GO:0010038 response to metal ion IPR004323; IPR011322; Protein CutA homolog cuta Xenopus laevis (African clawed frog) TR40848_c1_g2_i1 Q5UQP4 ADPRL_MIMIV 3.00E-34 GO:0016787 hydrolase activity IPR005502; Putative ADP-ribosyl glycohydrolase L444 (EC 3.2.2.-) MIMI_L444 Acanthamoeba polyphaga mimivirus (APMV) TR40848_c1_g2_i2 P54923 ADPRH_MOUSE 4.00E-118 GO:0003875; GO:0006464; GO:0000287; GO:0051725 ADP-ribosylarginine hydrolase activity; cellular protein modification process; magnesium ion binding; protein de-ADP-ribosylation IPR012108; IPR005502; [Protein ADP-ribosylarginine] hydrolase (ADP-ribosylarginine hydrolase) (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme) Adprh Arh1 Mus musculus (Mouse) TR40850_c1_g1_i2 Q80SY5 PR38B_MOUSE 7.00E-89 GO:0008380; GO:0006397; GO:0005681 RNA splicing; mRNA processing; spliceosomal complex IPR005037; Pre-mRNA-splicing factor 38B Prpf38b Mus musculus (Mouse) TR40850_c1_g1_i3 Q6P7Y3 PR38B_DANRE 2.00E-87 GO:0008380; GO:0006397; GO:0005681 RNA splicing; mRNA processing; spliceosomal complex IPR005037; Pre-mRNA-splicing factor 38B prpf38b Danio rerio (Zebrafish) (Brachydanio rerio) TR40850_c1_g1_i6 Q80SY5 PR38B_MOUSE 6.00E-91 GO:0008380; GO:0006397; GO:0005681 RNA splicing; mRNA processing; spliceosomal complex IPR005037; Pre-mRNA-splicing factor 38B Prpf38b Mus musculus (Mouse) TR40851_c0_g1_i2 O60543 CIDEA_HUMAN 8.00E-18 GO:0006309; GO:0006629; GO:0005811; GO:0019915; GO:0005740; GO:0043066; GO:0050710; GO:1900118; GO:0050995; GO:0030512; GO:0032720; GO:0005634; GO:0010890; GO:0042803; GO:0006355; GO:0035634; GO:0001659; GO:0006351 "apoptotic DNA fragmentation; lipid metabolic process; lipid particle; lipid storage; mitochondrial envelope; negative regulation of apoptotic process; negative regulation of cytokine secretion; negative regulation of execution phase of apoptosis; negative regulation of lipid catabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of tumor necrosis factor production; nucleus; positive regulation of sequestering of triglyceride; protein homodimerization activity; regulation of transcription, DNA-dependent; response to stilbenoid; temperature homeostasis; transcription, DNA-dependent" IPR003508; Cell death activator CIDE-A (Cell death-inducing DFFA-like effector A) CIDEA Homo sapiens (Human) TR40851_c0_g1_i3 O54786 DFFA_MOUSE 2.00E-18 GO:0006309; GO:0005737; GO:1900118; GO:0000790; GO:0005634; GO:0043065; GO:0070242 O54788 apoptotic DNA fragmentation; cytoplasm; negative regulation of execution phase of apoptosis; nuclear chromatin; nucleus; positive regulation of apoptotic process; thymocyte apoptotic process IPR003508; IPR027296; IPR017299; IPR015121; DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) Dffa Icad Mus musculus (Mouse) TR40852_c1_g2_i1 Q60954 MEIS1_MOUSE 1.00E-125 GO:0003677; GO:0003705; GO:0001525; GO:0048514; GO:0003682; GO:0060216; GO:0002089; GO:0045638; GO:0045665; GO:0005634; GO:0006357; GO:0043565; GO:0005667 Q62424 DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; angiogenesis; blood vessel morphogenesis; chromatin binding; definitive hemopoiesis; lens morphogenesis in camera-type eye; negative regulation of myeloid cell differentiation; negative regulation of neuron differentiation; nucleus; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor complex IPR001356; IPR008422; IPR009057; Homeobox protein Meis1 (Myeloid ecotropic viral integration site 1) Meis1 Mus musculus (Mouse) TR40852_c1_g2_i2 Q60954 MEIS1_MOUSE 1.00E-125 GO:0003677; GO:0003705; GO:0001525; GO:0048514; GO:0003682; GO:0060216; GO:0002089; GO:0045638; GO:0045665; GO:0005634; GO:0006357; GO:0043565; GO:0005667 Q62424 DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; angiogenesis; blood vessel morphogenesis; chromatin binding; definitive hemopoiesis; lens morphogenesis in camera-type eye; negative regulation of myeloid cell differentiation; negative regulation of neuron differentiation; nucleus; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor complex IPR001356; IPR008422; IPR009057; Homeobox protein Meis1 (Myeloid ecotropic viral integration site 1) Meis1 Mus musculus (Mouse) TR40852_c1_g2_i3 A6NDR6 ME3L1_HUMAN 2.00E-71 GO:0005634; GO:0043565; GO:0003700 nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR001356; IPR008422; IPR009057; Putative homeobox protein Meis3-like 1 MEIS3P1 Homo sapiens (Human) TR40852_c1_g2_i4 O46339 HTH_DROME 2.00E-65 GO:0003677; GO:0003705; GO:0007420; GO:0001752; GO:0005737; GO:0048735; GO:0007480; GO:0007476; GO:0007479; GO:0005634; GO:0007422; GO:0045944; GO:0000060; GO:0042659; GO:0045664; GO:0007432; GO:0043565; GO:0007525; GO:0010092; GO:0007383; GO:0005667 P40427 "DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; brain development; compound eye photoreceptor fate commitment; cytoplasm; haltere morphogenesis; imaginal disc-derived leg morphogenesis; imaginal disc-derived wing morphogenesis; leg disc proximal/distal pattern formation; nucleus; peripheral nervous system development; positive regulation of transcription from RNA polymerase II promoter; protein import into nucleus, translocation; regulation of cell fate specification; regulation of neuron differentiation; salivary gland boundary specification; sequence-specific DNA binding; somatic muscle development; specification of organ identity; specification of segmental identity, antennal segment; transcription factor complex" IPR001356; IPR008422; IPR009057; Homeobox protein homothorax (Homeobox protein dorsotonals) hth dtl CG17117 Drosophila melanogaster (Fruit fly) TR40853_c0_g1_i1 F7H9X2 TRIM2_CALJA 5.00E-26 GO:0005737; GO:0043523; GO:0004842; GO:0008270 cytoplasm; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Callithrix jacchus (White-tufted-ear marmoset) TR40854_c2_g1_i2 Q6PA48 TBRG4_XENLA 8.00E-27 GO:0045333; GO:0005739; GO:0004672; GO:0006468 cellular respiration; mitochondrion; protein kinase activity; protein phosphorylation IPR013579; IPR010622; IPR013584; Protein TBRG4 (Transforming growth factor beta regulator 4) tbrg4 Xenopus laevis (African clawed frog) TR40854_c2_g1_i3 Q6PA48 TBRG4_XENLA 8.00E-27 GO:0045333; GO:0005739; GO:0004672; GO:0006468 cellular respiration; mitochondrion; protein kinase activity; protein phosphorylation IPR013579; IPR010622; IPR013584; Protein TBRG4 (Transforming growth factor beta regulator 4) tbrg4 Xenopus laevis (African clawed frog) TR40857_c2_g3_i10 Q7XU38 C87A3_ORYSJ 1.00E-10 GO:0030659; GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705 "cytoplasmic vesicle membrane; heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Cytochrome P450 87A3 (EC 1.14.-.-) CYP87A3 Os04g0570000 LOC_Os04g48170 OSJNBa0088I22.16 Oryza sativa subsp. japonica (Rice) TR40857_c2_g3_i2 Q27516 C13A8_CAEEL 6.00E-21 GO:0020037; GO:0005506; GO:0004497; GO:0016705 "heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Putative cytochrome P450 CYP13A8 (EC 1.14.-.-) cyp-13A8 cyp13a8 T10B9.4 Caenorhabditis elegans TR40857_c2_g3_i4 Q92113 CP17A_SQUAC 5.00E-86 GO:0047442; GO:0020037; GO:0005506; GO:0016020; GO:0004508; GO:0006694 17-alpha-hydroxyprogesterone aldolase activity; heme binding; iron ion binding; membrane; steroid 17-alpha-monooxygenase activity; steroid biosynthetic process IPR001128; IPR017972; IPR002401; Lipid metabolism; steroid biosynthesis. "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.99.9) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Squalus acanthias (Spiny dogfish) TR40857_c2_g3_i6 Q9VG17 CP304_DROME 2.00E-42 GO:0005789; GO:0020037; GO:0005506; GO:0004497; GO:0016705 "endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Probable cytochrome P450 304a1 (EC 1.14.-.-) (CYPCCCIVA1) Cyp304a1 CG7241 Drosophila melanogaster (Fruit fly) TR40857_c2_g3_i7 Q29478 CP2CV_CAPAE 3.00E-38 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 2C31 (EC 1.14.14.1) (CYPIIC31) (Fragment) CYP2C31 Capra aegagrus (Wild goat) TR40857_c2_g3_i9 Q6V0L0 CP26C_HUMAN 2.00E-06 GO:0009952; GO:0007417; GO:0005789; GO:0020037; GO:0016021; GO:0005506; GO:0048387; GO:0014032; GO:0048284; GO:0008401; GO:0001972; GO:0034653; GO:0006805 anterior/posterior pattern specification; central nervous system development; endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding; negative regulation of retinoic acid receptor signaling pathway; neural crest cell development; organelle fusion; retinoic acid 4-hydroxylase activity; retinoic acid binding; retinoic acid catabolic process; xenobiotic metabolic process IPR001128; IPR017972; IPR002403; Cytochrome P450 26C1 (EC 1.14.-.-) CYP26C1 Homo sapiens (Human) TR40858_c0_g1_i3 Q6UX65 DRAM2_HUMAN 2.00E-29 GO:0005794; GO:0030262; GO:0016021; GO:0005765; GO:0005764 Golgi apparatus; apoptotic nuclear changes; integral to membrane; lysosomal membrane; lysosome IPR027315; IPR019402; DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77) DRAM2 TMEM77 PSEC0031 UNQ154/PRO180 Homo sapiens (Human) TR40859_c1_g1_i1 Q9JK72 CCS_RAT 5.00E-21 GO:0005829; GO:0019899; GO:0015680; GO:0005743; GO:0005634; GO:0019430; GO:0004784; GO:0016532; GO:0008270 cytosol; enzyme binding; intracellular copper ion transport; mitochondrial inner membrane; nucleus; removal of superoxide radicals; superoxide dismutase activity; superoxide dismutase copper chaperone activity; zinc ion binding IPR006121; IPR024134; IPR018152; IPR001424; Copper chaperone for superoxide dismutase (Superoxide dismutase copper chaperone) Ccs Rattus norvegicus (Rat) TR40859_c1_g1_i2 Q6BK66 CCS1_DEBHA 1.00E-05 GO:0005737; GO:0046872; GO:0030001; GO:0055114; GO:0006801 cytoplasm; metal ion binding; metal ion transport; oxidation-reduction process; superoxide metabolic process IPR006121; IPR024134; IPR001424; Superoxide dismutase 1 copper chaperone CCS1 DEHA2F24486g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR40859_c1_g4_i1 P07505 SODCP_SPIOL 1.00E-08 GO:0009507; GO:0046872; GO:0004784; GO:0006801 chloroplast; metal ion binding; superoxide dismutase activity; superoxide metabolic process IPR024134; IPR018152; IPR001424; "Superoxide dismutase [Cu-Zn], chloroplastic (EC 1.15.1.1)" SODCP Spinacia oleracea (Spinach) TR40859_c1_g4_i2 Q6PWT7 CCS_PIG 1.00E-22 GO:0005737; GO:0046872; GO:0030001; GO:0004784; GO:0006801 cytoplasm; metal ion binding; metal ion transport; superoxide dismutase activity; superoxide metabolic process IPR006121; IPR024134; IPR018152; IPR001424; Copper chaperone for superoxide dismutase (Superoxide dismutase copper chaperone) CCS Sus scrofa (Pig) TR40860_c0_g1_i3 Q5NVI3 RED_PONAB 3.00E-84 GO:0005634 nucleus IPR012492; IPR012916; Protein Red (Cytokine IK) (IK factor) IK Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40861_c0_g2_i1 Q9DBL7 COASY_MOUSE 3.00E-131 GO:0005524; GO:0015937; GO:0005737; GO:0004140; GO:0005634; GO:0004595 ATP binding; coenzyme A biosynthetic process; cytoplasm; dephospho-CoA kinase activity; nucleus; pantetheine-phosphate adenylyltransferase activity IPR004821; IPR001977; IPR027417; IPR014729; Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. Bifunctional coenzyme A synthase (CoA synthase) [Includes: Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (PPAT); Dephospho-CoA kinase (DPCK) (EC 2.7.1.24) (Dephosphocoenzyme A kinase) (DPCOAK)] Coasy Ukr1 Mus musculus (Mouse) TR40861_c0_g2_i2 Q3ABL6 COAE_CARHZ 4.00E-39 GO:0005524; GO:0015937; GO:0005737; GO:0004140 ATP binding; coenzyme A biosynthetic process; cytoplasm; dephospho-CoA kinase activity IPR001977; IPR027417; Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase) coaE CHY_1647 Carboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) TR40861_c0_g2_i4 Q8DKG1 COAE_THEEB 8.00E-30 GO:0005524; GO:0015937; GO:0005737; GO:0004140 ATP binding; coenzyme A biosynthetic process; cytoplasm; dephospho-CoA kinase activity IPR001977; IPR027417; Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase) coaE tlr0898 Thermosynechococcus elongatus (strain BP-1) TR40862_c1_g1_i1 P34257 TC3A_CAEEL 3.00E-06 GO:0003677; GO:0015074; GO:0005634; GO:0004803; GO:0006313 "DNA binding; DNA integration; nucleus; transposase activity; transposition, DNA-mediated" IPR009057; IPR025898; IPR002492; Transposable element Tc3 transposase tc3a B0303.5 Caenorhabditis elegans TR40862_c7_g1_i1 P03934 TC1A_CAEEL 1.00E-14 GO:0003677; GO:0015074; GO:0004519; GO:0090305; GO:0005634; GO:0004803; GO:0006313 "DNA binding; DNA integration; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus; transposase activity; transposition, DNA-mediated" IPR002492; Transposable element Tc1 transposase tc1a tca T07D3.8 Caenorhabditis elegans TR40863_c1_g1_i1 Q5SNX7 GALC_DANRE 9.00E-144 GO:0005975; GO:0004336; GO:0006683; GO:0005764 carbohydrate metabolic process; galactosylceramidase activity; galactosylceramide catabolic process; lysosome IPR001286; IPR013781; IPR017853; Galactocerebrosidase (GALCERase) (EC 3.2.1.46) (Galactosylceramidase) galc galca si:ch211-199l3.4 zgc:92561 Danio rerio (Zebrafish) (Brachydanio rerio) TR40864_c0_g2_i1 Q7SXM7 PRP31_DANRE 0 GO:0071339; GO:0003723; GO:0046540; GO:0000244; GO:0000398; GO:0060041; GO:0005681 "MLL1 complex; RNA binding; U4/U6 x U5 tri-snRNP complex; assembly of spliceosomal tri-snRNP; mRNA splicing, via spliceosome; retina development in camera-type eye; spliceosomal complex" IPR002687; IPR012976; IPR027105; IPR019175; U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) prpf31 Danio rerio (Zebrafish) (Brachydanio rerio) TR40864_c0_g2_i3 Q8CCF0 PRP31_MOUSE 0 GO:0015030; GO:0071339; GO:0003723; GO:0005687; GO:0046540; GO:0000244; GO:0016607; GO:0043021; GO:0070990; GO:0005681 Cajal body; MLL1 complex; RNA binding; U4 snRNP; U4/U6 x U5 tri-snRNP complex; assembly of spliceosomal tri-snRNP; nuclear speck; ribonucleoprotein complex binding; snRNP binding; spliceosomal complex IPR002687; IPR012976; IPR027105; IPR019175; U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (U4/U6 snRNP 61 kDa protein) (Protein 61K) Prpf31 Prp31 Mus musculus (Mouse) TR40864_c0_g2_i4 P49704 PRP31_YEAST 3.00E-42 GO:0003723; GO:0046540; GO:0000244; GO:0005681; GO:0000387 RNA binding; U4/U6 x U5 tri-snRNP complex; assembly of spliceosomal tri-snRNP; spliceosomal complex; spliceosomal snRNP assembly IPR002687; IPR012976; IPR027105; IPR019175; Pre-mRNA-processing factor 31 PRP31 YGR091W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40864_c0_g2_i6 Q6NVP6 PRP31_XENTR 0 GO:0071339; GO:0003723; GO:0046540; GO:0000244; GO:0005681 MLL1 complex; RNA binding; U4/U6 x U5 tri-snRNP complex; assembly of spliceosomal tri-snRNP; spliceosomal complex IPR002687; IPR012976; IPR027105; IPR019175; U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) prpf31 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40864_c0_g2_i7 Q7SXM7 PRP31_DANRE 0 GO:0071339; GO:0003723; GO:0046540; GO:0000244; GO:0000398; GO:0060041; GO:0005681 "MLL1 complex; RNA binding; U4/U6 x U5 tri-snRNP complex; assembly of spliceosomal tri-snRNP; mRNA splicing, via spliceosome; retina development in camera-type eye; spliceosomal complex" IPR002687; IPR012976; IPR027105; IPR019175; U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) prpf31 Danio rerio (Zebrafish) (Brachydanio rerio) TR40865_c0_g1_i1 P82861 ADRO_SALFO 0 GO:0008203; GO:0005759; GO:0016491 cholesterol metabolic process; mitochondrial matrix; oxidoreductase activity IPR021163; IPR016040; IPR023753; Steroid metabolism; cholesterol metabolism. "NADPH:adrenodoxin oxidoreductase, mitochondrial (AR) (Adrenodoxin reductase) (EC 1.18.1.6) (Ferredoxin--NADP(+) reductase) (Ferredoxin reductase)" fdxr Salvelinus fontinalis (Brook trout) (Salmo fontinalis) TR40865_c0_g1_i2 P96219 GLTD_MYCTU 1.00E-13 GO:0051539; GO:0097054; GO:0005829; GO:0050660; GO:0004355; GO:0040007; GO:0046872; GO:0005886 "4 iron, 4 sulfur cluster binding; L-glutamate biosynthetic process; cytosol; flavin adenine dinucleotide binding; glutamate synthase (NADPH) activity; growth; metal ion binding; plasma membrane" IPR028261; IPR006005; IPR009051; IPR016040; IPR023753; IPR001327; Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NADP(+) route): step 1/1. Glutamate synthase [NADPH] small chain (EC 1.4.1.13) (Glutamate synthase subunit beta) (GLTS beta chain) gltD Rv3858c MT3973 Mycobacterium tuberculosis TR40866_c0_g1_i1 Q1HFZ0 NSUN2_MOUSE 0 GO:0051301; GO:0005737; GO:0007067; GO:0005730; GO:0005819; GO:0016428; GO:0000049 cell division; cytoplasm; mitosis; nucleolus; spindle; tRNA (cytosine-5-)-methyltransferase activity; tRNA binding IPR001678; IPR023267; IPR023270; tRNA (cytosine(34)-C(5))-methyltransferase (EC 2.1.1.203) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) Nsun2 D13Wsu123e Misu Mus musculus (Mouse) TR40866_c0_g1_i2 Q4V7N2 NSUN2_XENLA 0 GO:0005737; GO:0005730; GO:0016428; GO:0000049 cytoplasm; nucleolus; tRNA (cytosine-5-)-methyltransferase activity; tRNA binding IPR001678; IPR023267; IPR023270; tRNA (cytosine(34)-C(5))-methyltransferase (EC 2.1.1.203) (NOL1/NOP2/Sun domain family member 2) nsun2 Xenopus laevis (African clawed frog) TR40866_c0_g1_i3 B8CPH7 RSMF_SHEPW 3.00E-26 GO:0003723; GO:0005737; GO:0016434 RNA binding; cytoplasm; rRNA (cytosine) methyltransferase activity IPR001678; IPR011023; IPR023267; IPR027391; IPR023545; Ribosomal RNA small subunit methyltransferase F (EC 2.1.1.178) (16S rRNA m5C1407 methyltransferase) (rRNA (cytosine-C(5)-)-methyltransferase RsmF) rsmF swp_2828 Shewanella piezotolerans (strain WP3 / JCM 13877) TR40866_c0_g1_i4 Q1HFZ0 NSUN2_MOUSE 0 GO:0051301; GO:0005737; GO:0007067; GO:0005730; GO:0005819; GO:0016428; GO:0000049 cell division; cytoplasm; mitosis; nucleolus; spindle; tRNA (cytosine-5-)-methyltransferase activity; tRNA binding IPR001678; IPR023267; IPR023270; tRNA (cytosine(34)-C(5))-methyltransferase (EC 2.1.1.203) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) Nsun2 D13Wsu123e Misu Mus musculus (Mouse) TR40866_c0_g1_i5 O94268 NOP2_SCHPO 2.00E-20 GO:0003723; GO:0008173; GO:0008757; GO:0005730; GO:0005634; GO:0031167 RNA binding; RNA methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity; nucleolus; nucleus; rRNA methylation IPR001678; IPR018314; IPR011023; IPR023267; IPR023273; Putative ribosomal RNA methyltransferase nop2 (EC 2.1.1.-) (Nucleolar protein 2) SPBP8B7.20c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40866_c0_g1_i6 Q9V106 TRCM_PYRAB 6.00E-30 GO:0005737; GO:0006364; GO:0016428; GO:0000049 cytoplasm; rRNA processing; tRNA (cytosine-5-)-methyltransferase activity; tRNA binding IPR001678; IPR011023; IPR023267; tRNA (cytosine(49)-C(5))-methyltransferase (EC 2.1.1.-) PYRAB06230 PAB1947 Pyrococcus abyssi (strain GE5 / Orsay) TR40867_c1_g1_i1 Q7SYE0 ATG13_DANRE 2.00E-47 GO:0006914; GO:0005829; GO:0000407 autophagy; cytosol; pre-autophagosomal structure IPR018731; Autophagy-related protein 13 atg13 zgc:63526 Danio rerio (Zebrafish) (Brachydanio rerio) TR40867_c4_g1_i1 Q91YI1 ATG13_MOUSE 4.00E-13 GO:0070969; GO:0000045; GO:0005829; GO:0000407 ULK1-ATG13-FIP200 complex; autophagic vacuole assembly; cytosol; pre-autophagosomal structure IPR018731; Autophagy-related protein 13 Atg13 D2Ertd391e Kiaa0652 Mus musculus (Mouse) TR40868_c2_g1_i1 P26378 ELAV4_HUMAN 1.00E-57 GO:0017091; GO:0003730; GO:0006397; GO:0000166 AU-rich element binding; mRNA 3'-UTR binding; mRNA processing; nucleotide binding IPR006548; IPR002343; IPR012677; IPR000504; ELAV-like protein 4 (Hu-antigen D) (HuD) (Paraneoplastic encephalomyelitis antigen HuD) ELAVL4 HUD PNEM Homo sapiens (Human) TR40868_c2_g1_i2 Q7SZT7 ELAV4_XENLA 1.00E-133 GO:0003723; GO:0007275; GO:0000166; GO:0030529 RNA binding; multicellular organismal development; nucleotide binding; ribonucleoprotein complex IPR006548; IPR002343; IPR012677; IPR000504; ELAV-like protein 4 (Protein ElrD) elavl4 elrD Xenopus laevis (African clawed frog) TR40868_c2_g1_i3 Q28GD4 ELAV2_XENTR 7.00E-138 GO:0003723; GO:0005938; GO:0007275; GO:0000166; GO:0030529 RNA binding; cell cortex; multicellular organismal development; nucleotide binding; ribonucleoprotein complex IPR006548; IPR002343; IPR012677; IPR000504; ELAV-like protein 2 (Protein ElrB) elavl2 elrB TEgg126j06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40869_c0_g2_i1 Q7Z7K2 ZN467_HUMAN 1.00E-16 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 467 ZNF467 Homo sapiens (Human) TR40869_c0_g2_i2 A0MS83 ZN148_DANRE 2.00E-14 GO:0003677; GO:0030097; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; hemopoiesis; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) znf148 zbp89 si:dkey-101k6.6 Danio rerio (Zebrafish) (Brachydanio rerio) TR40869_c0_g2_i4 Q08ER8 ZN543_HUMAN 3.00E-16 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 543 ZNF543 Homo sapiens (Human) TR40870_c1_g2_i1 Q8H5F8 ADPRM_ORYSJ 1.00E-58 GO:0047631; GO:0047734; GO:0046872 ADP-ribose diphosphatase activity; CDP-glycerol diphosphatase activity; metal ion binding IPR004843; Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (EC 3.6.1.13) (EC 3.6.1.16) (EC 3.6.1.53) (ADPRibase-Mn) (CDP-choline phosphohydrolase) Os07g0688000 LOC_Os07g48840 OJ1150_E04.129 OJ1165_F02.106 OsJ_25650 Oryza sativa subsp. japonica (Rice) TR40870_c1_g2_i2 A7YY53 ADPRM_BOVIN 2.00E-68 GO:0047631; GO:0047734; GO:0046872 ADP-ribose diphosphatase activity; CDP-glycerol diphosphatase activity; metal ion binding IPR004843; Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (EC 3.6.1.13) (EC 3.6.1.16) (EC 3.6.1.53) (ADPRibase-Mn) (CDP-choline phosphohydrolase) ADPRM Bos taurus (Bovine) TR40870_c1_g2_i5 Q7T291 ADPRM_DANRE 3.00E-59 GO:0008663; GO:0047631; GO:0047734; GO:0030145 "2',3'-cyclic-nucleotide 2'-phosphodiesterase activity; ADP-ribose diphosphatase activity; CDP-glycerol diphosphatase activity; manganese ion binding" IPR024654; Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (EC 3.6.1.13) (EC 3.6.1.16) (EC 3.6.1.53) (ADPRibase-Mn) (CDP-choline phosphohydrolase) adprm zgc:64213 Danio rerio (Zebrafish) (Brachydanio rerio) TR40870_c1_g2_i7 A7YY53 ADPRM_BOVIN 1.00E-68 GO:0047631; GO:0047734; GO:0046872 ADP-ribose diphosphatase activity; CDP-glycerol diphosphatase activity; metal ion binding IPR004843; Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (EC 3.6.1.13) (EC 3.6.1.16) (EC 3.6.1.53) (ADPRibase-Mn) (CDP-choline phosphohydrolase) ADPRM Bos taurus (Bovine) TR40871_c1_g2_i1 P26697 GSTA3_CHICK 1.00E-20 GO:0005737; GO:0006749; GO:0004364 cytoplasm; glutathione metabolic process; glutathione transferase activity IPR010987; IPR004045; IPR003080; IPR004046; IPR012336; Glutathione S-transferase 3 (EC 2.5.1.18) (GST class-alpha) (GST-CL3) Gallus gallus (Chicken) TR40871_c1_g2_i10 Q9N0V4 GSTM1_BOVIN 7.00E-24 GO:0005737; GO:0004364 cytoplasm; glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR003081; IPR012336; Glutathione S-transferase Mu 1 (EC 2.5.1.18) (GST class-mu 1) (GSTM1-1) GSTM1 GSTM Bos taurus (Bovine) TR40871_c1_g2_i2 P80031 GSTP1_PIG 4.00E-56 GO:0004364; GO:0005739; GO:0005634 glutathione transferase activity; mitochondrion; nucleus IPR010987; IPR004045; IPR004046; IPR003082; IPR012336; Glutathione S-transferase P (EC 2.5.1.18) (GST P1-1) (GST class-pi) GSTP1 Sus scrofa (Pig) TR40871_c1_g2_i3 Q8JFZ2 GSTP1_XENLA 9.00E-40 GO:0006749; GO:0004364; GO:0005739; GO:0005634 glutathione metabolic process; glutathione transferase activity; mitochondrion; nucleus IPR010987; IPR004045; IPR004046; IPR003082; IPR012336; Glutathione S-transferase P 1 (EC 2.5.1.18) (GST class-pi) (GST-Pi) (XlGSTP1-1) gstp1 Xenopus laevis (African clawed frog) TR40871_c1_g2_i4 P46426 GSTP_DIRIM 4.00E-46 GO:0004364 glutathione transferase activity IPR010987; IPR004045; IPR004046; IPR003082; IPR012336; Glutathione S-transferase (EC 2.5.1.18) (GST class-pi) Dirofilaria immitis (Canine heartworm) TR40871_c1_g2_i5 Q556G3 GSTA2_DICDI 3.00E-11 GO:0004364; GO:0045335 glutathione transferase activity; phagocytic vesicle IPR010987; IPR004045; IPR004046; IPR012336; Putative glutathione S-transferase alpha-2 (EC 2.5.1.18) (GST class-alpha 2) gsta2-1 DDB_G0272632; gsta2-2 DDB_G0274081 Dictyostelium discoideum (Slime mold) TR40871_c1_g2_i7 Q9N4X8 GSTPA_CAEEL 3.00E-32 GO:0008340; GO:0006749; GO:0004364; GO:0055114; GO:0010225; GO:0042542 determination of adult lifespan; glutathione metabolic process; glutathione transferase activity; oxidation-reduction process; response to UV-C; response to hydrogen peroxide IPR010987; IPR004045; IPR004046; IPR012336; Glutathione S-transferase P 10 (EC 2.5.1.18) (GST 5.4) (GST class-pi) (GSTP2-2) gst-10 Y45G12C.2 Caenorhabditis elegans TR40871_c1_g2_i8 P80031 GSTP1_PIG 3.00E-56 GO:0004364; GO:0005739; GO:0005634 glutathione transferase activity; mitochondrion; nucleus IPR010987; IPR004045; IPR004046; IPR003082; IPR012336; Glutathione S-transferase P (EC 2.5.1.18) (GST P1-1) (GST class-pi) GSTP1 Sus scrofa (Pig) TR40871_c1_g2_i9 Q8JFZ2 GSTP1_XENLA 1.00E-39 GO:0006749; GO:0004364; GO:0005739; GO:0005634 glutathione metabolic process; glutathione transferase activity; mitochondrion; nucleus IPR010987; IPR004045; IPR004046; IPR003082; IPR012336; Glutathione S-transferase P 1 (EC 2.5.1.18) (GST class-pi) (GST-Pi) (XlGSTP1-1) gstp1 Xenopus laevis (African clawed frog) TR40872_c0_g1_i1 P98081 DAB_DROME 2.00E-43 GO:0030424; GO:0007349; GO:0072583; GO:0042051; GO:0005737; GO:0007391; GO:0008045; GO:0045500; GO:0048488 axon; cellularization; clathrin-mediated endocytosis; compound eye photoreceptor development; cytoplasm; dorsal closure; motor neuron axon guidance; sevenless signaling pathway; synaptic vesicle endocytosis IPR011993; IPR006020; Protein disabled Dab CG9695 Drosophila melanogaster (Fruit fly) TR40873_c0_g1_i1 A7Z056 UBP20_BOVIN 0 GO:0005813; GO:0004197; GO:0006897; GO:0048471; GO:0071108; GO:0070536; GO:0008277; GO:0004221; GO:0006511; GO:0008270 centrosome; cysteine-type endopeptidase activity; endocytosis; perinuclear region of cytoplasm; protein K48-linked deubiquitination; protein K63-linked deubiquitination; regulation of G-protein coupled receptor protein signaling pathway; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; zinc ion binding IPR006615; IPR018200; IPR001394; IPR013083; IPR001607; Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) USP20 Bos taurus (Bovine) TR40873_c0_g1_i4 A5PMR2 UBP33_DANRE 2.00E-65 GO:0007411; GO:0016477; GO:0005813; GO:0051298; GO:0004197; GO:0006897; GO:0048471; GO:0071108; GO:0070536; GO:0008277; GO:0004221; GO:0006511; GO:0004843; GO:0008270 axon guidance; cell migration; centrosome; centrosome duplication; cysteine-type endopeptidase activity; endocytosis; perinuclear region of cytoplasm; protein K48-linked deubiquitination; protein K63-linked deubiquitination; regulation of G-protein coupled receptor protein signaling pathway; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity; zinc ion binding IPR006615; IPR018200; IPR001394; IPR013083; IPR001607; Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) usp33 ch211-284g18.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR40875_c1_g1_i1 P32847 B3AT_ONCMY 1.00E-46 GO:0005452; GO:0016021 inorganic anion exchanger activity; integral to membrane IPR001717; IPR002977; IPR018241; IPR013769; IPR011531; IPR003020; IPR016152; Band 3 anion exchange protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) slc4a1 ae1 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR40875_c1_g1_i13 Q8NBS3 S4A11_HUMAN 0 GO:0016323; GO:0015106; GO:0046715; GO:0030003; GO:0042044; GO:0015252; GO:0005452; GO:0016021; GO:0046983; GO:0005272; GO:0015293 basolateral plasma membrane; bicarbonate transmembrane transporter activity; borate transmembrane transporter activity; cellular cation homeostasis; fluid transport; hydrogen ion channel activity; inorganic anion exchanger activity; integral to membrane; protein dimerization activity; sodium channel activity; symporter activity IPR011531; IPR003020; IPR016152; IPR002178; Sodium bicarbonate transporter-like protein 11 (Bicarbonate transporter-related protein 1) (Sodium borate cotransporter 1) (NaBC1) (Solute carrier family 4 member 11) SLC4A11 BTR1 Homo sapiens (Human) TR40875_c1_g1_i2 Q8NBS3 S4A11_HUMAN 0 GO:0016323; GO:0015106; GO:0046715; GO:0030003; GO:0042044; GO:0015252; GO:0005452; GO:0016021; GO:0046983; GO:0005272; GO:0015293 basolateral plasma membrane; bicarbonate transmembrane transporter activity; borate transmembrane transporter activity; cellular cation homeostasis; fluid transport; hydrogen ion channel activity; inorganic anion exchanger activity; integral to membrane; protein dimerization activity; sodium channel activity; symporter activity IPR011531; IPR003020; IPR016152; IPR002178; Sodium bicarbonate transporter-like protein 11 (Bicarbonate transporter-related protein 1) (Sodium borate cotransporter 1) (NaBC1) (Solute carrier family 4 member 11) SLC4A11 BTR1 Homo sapiens (Human) TR40875_c1_g1_i3 Q8NBS3 S4A11_HUMAN 0 GO:0016323; GO:0015106; GO:0046715; GO:0030003; GO:0042044; GO:0015252; GO:0005452; GO:0016021; GO:0046983; GO:0005272; GO:0015293 basolateral plasma membrane; bicarbonate transmembrane transporter activity; borate transmembrane transporter activity; cellular cation homeostasis; fluid transport; hydrogen ion channel activity; inorganic anion exchanger activity; integral to membrane; protein dimerization activity; sodium channel activity; symporter activity IPR011531; IPR003020; IPR016152; IPR002178; Sodium bicarbonate transporter-like protein 11 (Bicarbonate transporter-related protein 1) (Sodium borate cotransporter 1) (NaBC1) (Solute carrier family 4 member 11) SLC4A11 BTR1 Homo sapiens (Human) TR40875_c1_g1_i4 A2AJN7 S4A11_MOUSE 0 GO:0042044; GO:0005452; GO:0016021; GO:0050801; GO:0005886; GO:0046983; GO:0015293 fluid transport; inorganic anion exchanger activity; integral to membrane; ion homeostasis; plasma membrane; protein dimerization activity; symporter activity IPR011531; IPR003020; IPR016152; IPR002178; Sodium bicarbonate transporter-like protein 11 (Bicarbonate transporter-related protein 1) (Sodium borate cotransporter 1) (NaBC1) (Solute carrier family 4 member 11) Slc4a11 BTR1 Mus musculus (Mouse) TR40875_c1_g1_i7 Q8NBS3 S4A11_HUMAN 0 GO:0016323; GO:0015106; GO:0046715; GO:0030003; GO:0042044; GO:0015252; GO:0005452; GO:0016021; GO:0046983; GO:0005272; GO:0015293 basolateral plasma membrane; bicarbonate transmembrane transporter activity; borate transmembrane transporter activity; cellular cation homeostasis; fluid transport; hydrogen ion channel activity; inorganic anion exchanger activity; integral to membrane; protein dimerization activity; sodium channel activity; symporter activity IPR011531; IPR003020; IPR016152; IPR002178; Sodium bicarbonate transporter-like protein 11 (Bicarbonate transporter-related protein 1) (Sodium borate cotransporter 1) (NaBC1) (Solute carrier family 4 member 11) SLC4A11 BTR1 Homo sapiens (Human) TR40875_c1_g1_i9 Q6U841 S4A10_HUMAN 5.00E-56 GO:0016323; GO:0015701; GO:0006821; GO:0005452; GO:0016021; GO:0005886; GO:0006885; GO:0006814; GO:0015293; GO:0055085 basolateral plasma membrane; bicarbonate transport; chloride transport; inorganic anion exchanger activity; integral to membrane; plasma membrane; regulation of pH; sodium ion transport; symporter activity; transmembrane transport IPR013769; IPR011531; IPR003020; IPR003024; IPR016152; Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10) SLC4A10 NCBE Homo sapiens (Human) TR40876_c0_g1_i1 Q8XBJ0 YFEW_ECO57 9.00E-08 IPR001466; IPR012338; IPR022849; UPF0214 protein YfeW yfeW Z3695 ECs3301 Escherichia coli O157:H7 TR40876_c0_g1_i3 Q5HDB2 FLP_STAAC 1.00E-10 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR001466; IPR012338; Protein flp (FmtA-like protein) flp SACOL2445 Staphylococcus aureus (strain COL) TR40877_c4_g1_i2 Q54EH3 Y1510_DICDI 1.00E-44 GO:0005096; GO:0043547; GO:0051056; GO:0005083 GTPase activator activity; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; small GTPase regulator activity IPR001180; IPR000331; GTPase-activating protein DDB_G0291510 DDB_G0291510 Dictyostelium discoideum (Slime mold) TR40877_c4_g1_i3 P47736 RPGP1_HUMAN 2.00E-131 GO:0005096; GO:0003924; GO:0000139; GO:0005829; GO:0016020; GO:0032318; GO:0007165 P61224 GTPase activator activity; GTPase activity; Golgi membrane; cytosol; membrane; regulation of Ras GTPase activity; signal transduction IPR003109; IPR000331; Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) RAP1GAP KIAA0474 RAP1GA1 Homo sapiens (Human) TR40880_c1_g5_i1 Q96RW7 HMCN1_HUMAN 1.00E-39 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR40881_c1_g1_i2 Q5R8H3 BAP31_PONAB 3.00E-39 GO:0006915; GO:0005789; GO:0033116; GO:0016021; GO:0006886; GO:0016192 apoptotic process; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; intracellular protein transport; vesicle-mediated transport IPR008417; B-cell receptor-associated protein 31 (BCR-associated protein 31) (Bap31) BCAP31 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40882_c0_g1_i1 Q16739 CEGT_HUMAN 9.00E-135 GO:0000139; GO:0008120; GO:0008544; GO:0006679; GO:0016021; GO:0044281 Golgi membrane; ceramide glucosyltransferase activity; epidermis development; glucosylceramide biosynthetic process; integral to membrane; small molecule metabolic process IPR025993; Lipid metabolism; sphingolipid metabolism. Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase) UGCG Homo sapiens (Human) TR40883_c0_g2_i1 Q9UBS5 GABR1_HUMAN 0 GO:0004965; GO:0038039; GO:0007193; GO:0030054; GO:0005737; GO:0030425; GO:0005576; GO:0007214; GO:0005887; GO:0007194; GO:0045211; GO:0042734; GO:0007268 P61244; P16333; P46459 G-protein coupled GABA receptor activity; G-protein coupled receptor heterodimeric complex; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; cell junction; cytoplasm; dendrite; extracellular region; gamma-aminobutyric acid signaling pathway; integral to plasma membrane; negative regulation of adenylate cyclase activity; postsynaptic membrane; presynaptic membrane; synaptic transmission IPR001828; IPR017978; IPR002455; IPR002456; IPR028082; IPR000436; Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1) GABBR1 GPRC3A Homo sapiens (Human) TR40883_c0_g2_i11 Q54QG7 GRLN_DICDI 9.00E-08 GO:0004930; GO:0016021 G-protein coupled receptor activity; integral to membrane IPR017978; Metabotropic glutamate receptor-like protein N grlN DDB_G0283839 Dictyostelium discoideum (Slime mold) TR40883_c0_g2_i2 Q55AP1 GRLA_DICDI 9.00E-17 GO:0004930; GO:0005938; GO:0005789; GO:0016021; GO:0005635; GO:0048471; GO:0005886; GO:0030587; GO:0030435 G-protein coupled receptor activity; cell cortex; endoplasmic reticulum membrane; integral to membrane; nuclear envelope; perinuclear region of cytoplasm; plasma membrane; sorocarp development; sporulation resulting in formation of a cellular spore IPR003760; IPR017978; IPR028082; Metabotropic glutamate receptor-like protein A grlA DDB_G0271684 Dictyostelium discoideum (Slime mold) TR40883_c0_g2_i3 Q9UBS5 GABR1_HUMAN 0 GO:0004965; GO:0038039; GO:0007193; GO:0030054; GO:0005737; GO:0030425; GO:0005576; GO:0007214; GO:0005887; GO:0007194; GO:0045211; GO:0042734; GO:0007268 P61244; P16333; P46459 G-protein coupled GABA receptor activity; G-protein coupled receptor heterodimeric complex; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; cell junction; cytoplasm; dendrite; extracellular region; gamma-aminobutyric acid signaling pathway; integral to plasma membrane; negative regulation of adenylate cyclase activity; postsynaptic membrane; presynaptic membrane; synaptic transmission IPR001828; IPR017978; IPR002455; IPR002456; IPR028082; IPR000436; Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1) GABBR1 GPRC3A Homo sapiens (Human) TR40883_c0_g2_i4 Q55AP3 GRLO_DICDI 1.00E-16 GO:0004965; GO:0016021 G-protein coupled GABA receptor activity; integral to membrane IPR017978; IPR002455; Metabotropic glutamate receptor-like protein O grlO DDB_G0271688 Dictyostelium discoideum (Slime mold) TR40883_c0_g2_i6 O75899 GABR2_HUMAN 2.00E-162 GO:0004965; GO:0038039; GO:0030054; GO:0005737; GO:0007214; GO:0005887; GO:0007194; GO:0043005; GO:0045211; GO:0007268 P46459 G-protein coupled GABA receptor activity; G-protein coupled receptor heterodimeric complex; cell junction; cytoplasm; gamma-aminobutyric acid signaling pathway; integral to plasma membrane; negative regulation of adenylate cyclase activity; neuron projection; postsynaptic membrane; synaptic transmission IPR001828; IPR000337; IPR017978; IPR017979; IPR002455; IPR002457; IPR028082; Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20) GABBR2 GPR51 GPRC3B Homo sapiens (Human) TR40883_c0_g2_i7 Q9UBS5 GABR1_HUMAN 3.00E-119 GO:0004965; GO:0038039; GO:0007193; GO:0030054; GO:0005737; GO:0030425; GO:0005576; GO:0007214; GO:0005887; GO:0007194; GO:0045211; GO:0042734; GO:0007268 P61244; P16333; P46459 G-protein coupled GABA receptor activity; G-protein coupled receptor heterodimeric complex; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; cell junction; cytoplasm; dendrite; extracellular region; gamma-aminobutyric acid signaling pathway; integral to plasma membrane; negative regulation of adenylate cyclase activity; postsynaptic membrane; presynaptic membrane; synaptic transmission IPR001828; IPR017978; IPR002455; IPR002456; IPR028082; IPR000436; Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1) GABBR1 GPRC3A Homo sapiens (Human) TR40883_c0_g2_i9 Q80T41 GABR2_MOUSE 6.00E-87 GO:0004965; GO:0038039; GO:0030054; GO:0005737; GO:0007214; GO:0005887; GO:0043005; GO:0045211 G-protein coupled GABA receptor activity; G-protein coupled receptor heterodimeric complex; cell junction; cytoplasm; gamma-aminobutyric acid signaling pathway; integral to plasma membrane; neuron projection; postsynaptic membrane IPR001828; IPR000337; IPR017978; IPR017979; IPR002455; IPR002457; IPR028082; Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) Gabbr2 Gm425 Gpr51 Mus musculus (Mouse) TR40884_c2_g1_i1 Q923S6 NEU1A_MOUSE 2.00E-77 GO:0007219; GO:0005737; GO:0007595; GO:0016874; GO:0048471; GO:0005886; GO:0045741; GO:0016567; GO:0007288; GO:0030317; GO:0008270 Q7TN99 Notch signaling pathway; cytoplasm; lactation; ligase activity; perinuclear region of cytoplasm; plasma membrane; positive regulation of epidermal growth factor-activated receptor activity; protein ubiquitination; sperm axoneme assembly; sperm motility; zinc ion binding IPR006573; IPR001841; IPR013083; Protein modification; protein ubiquitination. Neuralized-like protein 1A (m-neu1) (m-neuralized 1) (EC 6.3.2.-) Neurl Neurl1 Neurl1a Mus musculus (Mouse) TR40885_c0_g1_i1 P49581 ACHA6_CHICK 8.00E-07 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 Gallus gallus (Chicken) TR40885_c0_g3_i10 Q07263 ACHA3_BOVIN 7.00E-17 GO:0015464; GO:0004889; GO:0005892; GO:0035095; GO:0030054; GO:0007399; GO:0045211; GO:0060084 acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; behavioral response to nicotine; cell junction; nervous system development; postsynaptic membrane; synaptic transmission involved in micturition IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 Bos taurus (Bovine) TR40885_c0_g3_i11 P02718 ACHD_TORCA 2.00E-12 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit delta CHNRD Torpedo californica (Pacific electric ray) TR40885_c0_g3_i5 P49581 ACHA6_CHICK 8.00E-16 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 Gallus gallus (Chicken) TR40885_c0_g3_i8 P30532 ACHA5_HUMAN 1.00E-10 GO:0015464; GO:0004889; GO:0005892; GO:0035095; GO:0030054; GO:0045211 acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; behavioral response to nicotine; cell junction; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 NACHRA5 Homo sapiens (Human) TR40885_c0_g3_i9 P30926 ACHB4_HUMAN 6.00E-14 GO:0015464; GO:0004889; GO:0005892; GO:0035095; GO:0030054; GO:0007626; GO:0045211; GO:0001508; GO:0046928; GO:0006940; GO:0006939; GO:0060084; GO:0007271 "acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; behavioral response to nicotine; cell junction; locomotory behavior; postsynaptic membrane; regulation of action potential; regulation of neurotransmitter secretion; regulation of smooth muscle contraction; smooth muscle contraction; synaptic transmission involved in micturition; synaptic transmission, cholinergic" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit beta-4 CHRNB4 Homo sapiens (Human) TR40887_c0_g1_i1 O62846 KAPCG_MACMU 1.00E-14 GO:0005524; GO:0004691 ATP binding; cAMP-dependent protein kinase activity IPR011009; IPR000719; IPR017441; IPR008271; cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11) (Fragment) PRKACG Macaca mulatta (Rhesus macaque) TR40887_c1_g1_i3 Q14012 KCC1A_HUMAN 4.00E-101 GO:0005524; GO:0004683; GO:0007049; GO:0005737; GO:0006913; GO:0005634; GO:0060999; GO:0051149; GO:0010976; GO:0046827; GO:0071902; GO:0051835; GO:0043393; GO:0032880; GO:0007165 ATP binding; calmodulin-dependent protein kinase activity; cell cycle; cytoplasm; nucleocytoplasmic transport; nucleus; positive regulation of dendritic spine development; positive regulation of muscle cell differentiation; positive regulation of neuron projection development; positive regulation of protein export from nucleus; positive regulation of protein serine/threonine kinase activity; positive regulation of synapse structural plasticity; regulation of protein binding; regulation of protein localization; signal transduction IPR020636; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) CAMK1 Homo sapiens (Human) TR40887_c1_g2_i1 Q63450 KCC1A_RAT 1.00E-112 GO:0005524; GO:0005954; GO:0004683; GO:0007049; GO:0005737; GO:0006913; GO:0005634; GO:0060999; GO:0051149; GO:0010976; GO:0046827; GO:0071902; GO:0051835; GO:0051147; GO:0043393; GO:0032880; GO:0007165 ATP binding; calcium- and calmodulin-dependent protein kinase complex; calmodulin-dependent protein kinase activity; cell cycle; cytoplasm; nucleocytoplasmic transport; nucleus; positive regulation of dendritic spine development; positive regulation of muscle cell differentiation; positive regulation of neuron projection development; positive regulation of protein export from nucleus; positive regulation of protein serine/threonine kinase activity; positive regulation of synapse structural plasticity; regulation of muscle cell differentiation; regulation of protein binding; regulation of protein localization; signal transduction IPR020636; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Camk1 Rattus norvegicus (Rat) TR4089_c0_g1_i1 Q63164 DYH1_RAT 3.00E-16 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR026975; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 1, axonemal (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1)" Dnah1 Dlp1 Rattus norvegicus (Rat) TR40890_c3_g2_i2 Q6PD21 SHB_MOUSE 4.00E-23 GO:0042100; GO:0005070; GO:0001525; GO:0006915; GO:0048514; GO:0030154; GO:0005737; GO:0001948; GO:0030097; GO:1900194; GO:0005886 B cell proliferation; SH3/SH2 adaptor activity; angiogenesis; apoptotic process; blood vessel morphogenesis; cell differentiation; cytoplasm; glycoprotein binding; hemopoiesis; negative regulation of oocyte maturation; plasma membrane IPR000980; SH2 domain-containing adapter protein B Shb Mus musculus (Mouse) TR40890_c3_g2_i5 Q6PD21 SHB_MOUSE 4.00E-23 GO:0042100; GO:0005070; GO:0001525; GO:0006915; GO:0048514; GO:0030154; GO:0005737; GO:0001948; GO:0030097; GO:1900194; GO:0005886 B cell proliferation; SH3/SH2 adaptor activity; angiogenesis; apoptotic process; blood vessel morphogenesis; cell differentiation; cytoplasm; glycoprotein binding; hemopoiesis; negative regulation of oocyte maturation; plasma membrane IPR000980; SH2 domain-containing adapter protein B Shb Mus musculus (Mouse) TR40891_c0_g1_i1 Q9SF85 ADK1_ARATH 1.00E-16 GO:0044209; GO:0005524; GO:0004001; GO:0006169; GO:0048046; GO:0009507; GO:0005507; GO:0005829; GO:0019048; GO:0016773; GO:0005886; GO:0009506; GO:0046686; GO:0080094 "AMP salvage; ATP binding; adenosine kinase activity; adenosine salvage; apoplast; chloroplast; copper ion binding; cytosol; modulation by virus of host morphology or physiology; phosphotransferase activity, alcohol group as acceptor; plasma membrane; plasmodesma; response to cadmium ion; response to trehalose-6-phosphate stimulus" IPR001805; IPR002173; IPR011611; Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1. Adenosine kinase 1 (AK 1) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase 1) ADK1 At3g09820 F8A24.13 Arabidopsis thaliana (Mouse-ear cress) TR40891_c0_g1_i2 P55262 ADK_CRIGR 2.00E-17 GO:0044209; GO:0005524; GO:0004001; GO:0046872; GO:0016773; GO:0006166 "AMP salvage; ATP binding; adenosine kinase activity; metal ion binding; phosphotransferase activity, alcohol group as acceptor; purine ribonucleoside salvage" IPR001805; IPR002173; IPR011611; Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1. Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase) ADK Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR40891_c2_g1_i1 O49923 ADK_PHYPA 2.00E-72 GO:0044209; GO:0005524; GO:0004001; GO:0016773; GO:0006166 "AMP salvage; ATP binding; adenosine kinase activity; phosphotransferase activity, alcohol group as acceptor; purine ribonucleoside salvage" IPR001805; IPR002173; IPR011611; Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1. Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase) ADK PHYPADRAFT_184505 Physcomitrella patens subsp. patens (Moss) TR40891_c3_g1_i1 Q5ZKE7 KCY_CHICK 1.00E-73 GO:0005524; GO:0004127; GO:0005737; GO:0004550; GO:0009142; GO:0005634; GO:0006221 ATP binding; cytidylate kinase activity; cytoplasm; nucleoside diphosphate kinase activity; nucleoside triphosphate biosynthetic process; nucleus; pyrimidine nucleotide biosynthetic process IPR000850; IPR027417; IPR006266; UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) CMPK CMPK1 RCJMB04_11f2 Gallus gallus (Chicken) TR40892_c0_g1_i1 Q2KJB7 CPT2_BOVIN 3.00E-75 GO:0004095; GO:0006631; GO:0005743; GO:0006810 carnitine O-palmitoyltransferase activity; fatty acid metabolic process; mitochondrial inner membrane; transport IPR000542; "Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II) (CPT II)" CPT2 Bos taurus (Bovine) TR40892_c0_g1_i2 P47934 CACP_MOUSE 0 GO:0004092; GO:0019254; GO:0005783; GO:0006631; GO:0005743; GO:0005739; GO:0005777; GO:0006810 "carnitine O-acetyltransferase activity; carnitine metabolic process, CoA-linked; endoplasmic reticulum; fatty acid metabolic process; mitochondrial inner membrane; mitochondrion; peroxisome; transport" IPR000542; Carnitine O-acetyltransferase (Carnitine acetylase) (EC 2.3.1.7) (Carnitine acetyltransferase) (CAT) (CrAT) Crat Mus musculus (Mouse) TR40893_c0_g2_i2 Q7ZU99 TERA_DANRE 0 GO:0005524; GO:0030433; GO:0007049; GO:0005829; GO:0006302; GO:0009790; GO:0008289; GO:0017111; GO:0005634; GO:0018279; GO:0016567; GO:2000058; GO:0035861; GO:0019985; GO:0006810 ATP binding; ER-associated protein catabolic process; cell cycle; cytosol; double-strand break repair; embryo development; lipid binding; nucleoside-triphosphatase activity; nucleus; protein N-linked glycosylation via asparagine; protein ubiquitination; regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; site of double-strand break; translesion synthesis; transport IPR003593; IPR005938; IPR009010; IPR003959; IPR003960; IPR004201; IPR003338; IPR027417; IPR015415; Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (Protein CDC48) (Valosin-containing protein) (VCP) vcp cdc48 si:ch211-113n10.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR40894_c2_g1_i2 Q96LY2 CC74B_HUMAN 3.00E-07 Coiled-coil domain-containing protein 74B CCDC74B Homo sapiens (Human) TR40895_c1_g1_i1 O75063 XYLK_HUMAN 1.00E-121 GO:0005524; GO:0005794; GO:0000139; GO:0016021; GO:0016301; GO:0016773 "ATP binding; Golgi apparatus; Golgi membrane; integral to membrane; kinase activity; phosphotransferase activity, alcohol group as acceptor" IPR009581; IPR024869; Glycosaminoglycan xylosylkinase (EC 2.7.1.-) (Protein FAM20B) (Xylose kinase) FAM20B KIAA0475 Homo sapiens (Human) TR40895_c2_g1_i6 A3KP40 CH034_DANRE 8.00E-08 IPR003117; Uncharacterized protein C8orf34 homolog zgc:162928 Danio rerio (Zebrafish) (Brachydanio rerio) TR40897_c0_g3_i1 O13798 CID16_SCHPO 1.00E-12 GO:0051301; GO:0005737; GO:0007067; GO:0004652 cell division; cytoplasm; mitosis; polynucleotide adenylyltransferase activity IPR002934; IPR002058; Caffeine-induced protein 16 cid16 SPAC17H9.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR40897_c0_g3_i2 Q9VD44 GLD2A_DROME 1.00E-64 GO:0005524; GO:0003723; GO:0043631; GO:0005737; GO:0007616; GO:0006397; GO:0046872; GO:0043005; GO:0005654; GO:0004652 ATP binding; RNA binding; RNA polyadenylation; cytoplasm; long-term memory; mRNA processing; metal ion binding; neuron projection; nucleoplasm; polynucleotide adenylyltransferase activity IPR002058; Poly(A) RNA polymerase gld-2 homolog A (DmGLD2) (EC 2.7.7.19) Gld2 CG5732 Drosophila melanogaster (Fruit fly) TR40898_c0_g2_i3 Q6AY20 MPRD_RAT 2.00E-18 GO:0016021; GO:0005765; GO:0005537; GO:0015578 integral to membrane; lysosomal membrane; mannose binding; mannose transmembrane transporter activity IPR009011; IPR000296; Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) M6pr Rattus norvegicus (Rat) TR40898_c0_g2_i8 Q6AY20 MPRD_RAT 1.00E-19 GO:0016021; GO:0005765; GO:0005537; GO:0015578 integral to membrane; lysosomal membrane; mannose binding; mannose transmembrane transporter activity IPR009011; IPR000296; Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) M6pr Rattus norvegicus (Rat) TR40899_c0_g3_i2 Q498W5 T198B_DANRE 4.00E-33 GO:0016021 integral to membrane IPR025256; Transmembrane protein 198-B tmem198b zgc:112212 Danio rerio (Zebrafish) (Brachydanio rerio) TR40899_c0_g3_i6 Q498W5 T198B_DANRE 2.00E-33 GO:0016021 integral to membrane IPR025256; Transmembrane protein 198-B tmem198b zgc:112212 Danio rerio (Zebrafish) (Brachydanio rerio) TR40902_c2_g1_i2 O77735 SCAM1_PIG 3.00E-81 GO:0005794; GO:0016021; GO:0015031; GO:0055038; GO:0005802 Golgi apparatus; integral to membrane; protein transport; recycling endosome membrane; trans-Golgi network IPR007273; Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1) SCAMP1 Sus scrofa (Pig) TR40903_c1_g3_i1 Q32Q07 LRRN1_RAT 6.00E-55 GO:0016021 integral to membrane IPR000483; IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeat neuronal protein 1 (Neuronal leucine-rich repeat protein 1) (NLRR-1) Lrrn1 Rattus norvegicus (Rat) TR40903_c1_g4_i1 Q96DM1 PGBD4_HUMAN 2.00E-45 PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) TR40903_c1_g4_i2 Q96DM1 PGBD4_HUMAN 2.00E-17 PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) TR40904_c3_g3_i2 Q9YGY3 BUB3_XENLA 0 GO:0051301; GO:0007059; GO:0000777; GO:0007126; GO:0007067; GO:0005634 cell division; chromosome segregation; condensed chromosome kinetochore; meiosis; mitosis; nucleus IPR020472; IPR015943; IPR001680; IPR017986; Mitotic checkpoint protein BUB3 (xbub3) (WD repeat protein Bub3) bub3 Xenopus laevis (African clawed frog) TR40905_c2_g2_i3 Q17QJ5 TSN5_BOVIN 5.00E-20 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-5 (Tspan-5) TSPAN5 Bos taurus (Bovine) TR40905_c2_g2_i4 P40240 CD9_MOUSE 5.00E-35 GO:0016324; GO:0007420; GO:0007155; GO:0006928; GO:0009897; GO:0007342; GO:0016021; GO:0008285; GO:0014003; GO:0030913; GO:0009414 apical plasma membrane; brain development; cell adhesion; cellular component movement; external side of plasma membrane; fusion of sperm to egg plasma membrane; integral to membrane; negative regulation of cell proliferation; oligodendrocyte development; paranodal junction assembly; response to water deprivation IPR000301; IPR018499; IPR018503; IPR008952; CD9 antigen (CD antigen CD9) Cd9 Mus musculus (Mouse) TR40905_c2_g2_i7 Q17QJ5 TSN5_BOVIN 5.00E-20 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-5 (Tspan-5) TSPAN5 Bos taurus (Bovine) TR40905_c2_g2_i8 P40240 CD9_MOUSE 7.00E-35 GO:0016324; GO:0007420; GO:0007155; GO:0006928; GO:0009897; GO:0007342; GO:0016021; GO:0008285; GO:0014003; GO:0030913; GO:0009414 apical plasma membrane; brain development; cell adhesion; cellular component movement; external side of plasma membrane; fusion of sperm to egg plasma membrane; integral to membrane; negative regulation of cell proliferation; oligodendrocyte development; paranodal junction assembly; response to water deprivation IPR000301; IPR018499; IPR018503; IPR008952; CD9 antigen (CD antigen CD9) Cd9 Mus musculus (Mouse) TR40909_c0_g1_i1 Q99JB7 AMNLS_MOUSE 7.00E-29 GO:0045177; GO:0007588; GO:0016021; GO:0007275; GO:0008104 apical part of cell; excretion; integral to membrane; multicellular organismal development; protein localization IPR026112; Protein amnionless Amn Mus musculus (Mouse) TR40909_c0_g1_i4 Q99JB7 AMNLS_MOUSE 2.00E-30 GO:0045177; GO:0007588; GO:0016021; GO:0007275; GO:0008104 apical part of cell; excretion; integral to membrane; multicellular organismal development; protein localization IPR026112; Protein amnionless Amn Mus musculus (Mouse) TR40910_c1_g1_i2 Q91ZU6 DYST_MOUSE 1.00E-14 GO:0031673; GO:0030018; GO:0015629; GO:0030424; GO:0007409; GO:0005509; GO:0007155; GO:0005938; GO:0007050; GO:0016023; GO:0031122; GO:0005789; GO:0005925; GO:0030056; GO:0016021; GO:0014704; GO:0005882; GO:0045104; GO:0009898; GO:0046907; GO:0015630; GO:0035371; GO:0051010; GO:0060053; GO:0005635; GO:0005634; GO:0097038; GO:0042803; GO:0031110; GO:0008090; GO:0042383; GO:0001725 P21807 H zone; Z disc; actin cytoskeleton; axon; axonogenesis; calcium ion binding; cell adhesion; cell cortex; cell cycle arrest; cytoplasmic membrane-bounded vesicle; cytoplasmic microtubule organization; endoplasmic reticulum membrane; focal adhesion; hemidesmosome; integral to membrane; intercalated disc; intermediate filament; intermediate filament cytoskeleton organization; internal side of plasma membrane; intracellular transport; microtubule cytoskeleton; microtubule plus end; microtubule plus-end binding; neurofilament cytoskeleton; nuclear envelope; nucleus; perinuclear endoplasmic reticulum; protein homodimerization activity; regulation of microtubule polymerization or depolymerization; retrograde axon cargo transport; sarcolemma; stress fiber IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; IPR003108; IPR001101; IPR018159; IPR002017; Dystonin (Bullous pemphigoid antigen 1) (BPA) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) (Microtubule actin cross-linking factor 2) Dst Bpag1 Macf2 Mus musculus (Mouse) TR40910_c1_g1_i3 Q8JZP9 GA2L1_MOUSE 7.00E-83 GO:0007050; GO:0009267; GO:0097067; GO:0005737; GO:0008093; GO:0005856; GO:0008017; GO:0001578; GO:0030308; GO:0045647; GO:0010629; GO:0007026; GO:0051726; GO:0046966 cell cycle arrest; cellular response to starvation; cellular response to thyroid hormone stimulus; cytoplasm; cytoskeletal adaptor activity; cytoskeleton; microtubule binding; microtubule bundle formation; negative regulation of cell growth; negative regulation of erythrocyte differentiation; negative regulation of gene expression; negative regulation of microtubule depolymerization; regulation of cell cycle; thyroid hormone receptor binding IPR001715; IPR003108; GAS2-like protein 1 (Growth arrest-specific protein 2-like 1) Gas2l1 Mus musculus (Mouse) TR40911_c4_g1_i1 Q17R09 PRP16_BOVIN 2.00E-23 GO:0005524; GO:0008026; GO:0008380; GO:0006397; GO:0003676; GO:0005681 ATP binding; ATP-dependent helicase activity; RNA splicing; mRNA processing; nucleic acid binding; spliceosomal complex IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38) DHX38 PRP16 Bos taurus (Bovine) TR40911_c5_g1_i2 Q2TA16 CCD65_BOVIN 5.00E-143 Coiled-coil domain-containing protein 65 CCDC65 Bos taurus (Bovine) TR40911_c5_g1_i3 Q2TA16 CCD65_BOVIN 6.00E-144 Coiled-coil domain-containing protein 65 CCDC65 Bos taurus (Bovine) TR40911_c5_g1_i6 Q5XI65 CC164_RAT 6.00E-08 GO:0070286; GO:0060285; GO:0035085; GO:0005856 axonemal dynein complex assembly; ciliary cell motility; cilium axoneme; cytoskeleton Dynein regulatory complex protein 1 (Coiled-coil domain-containing protein 164) Drc1 Ccdc164 Rattus norvegicus (Rat) TR40913_c3_g2_i1 Q5ZHP5 CHM4B_CHICK 9.00E-54 GO:0005829; GO:0031902; GO:0030496; GO:0015031 cytosol; late endosome membrane; midbody; protein transport IPR005024; Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) CHMP4B RCJMB04_34n7 Gallus gallus (Chicken) TR40913_c3_g2_i2 Q5XGW6 CHM4B_XENLA 9.00E-60 GO:0005829; GO:0031902; GO:0015031 cytosol; late endosome membrane; protein transport IPR005024; Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) chmp4b Xenopus laevis (African clawed frog) TR40914_c0_g2_i2 P30665 MCM4_YEAST 1.00E-103 GO:0005524; GO:0003678; GO:0006270; GO:0003688; GO:0031261; GO:0006271; GO:0006268; GO:0042555; GO:0097373; GO:0005737; GO:0000727; GO:0005656; GO:0006267; GO:0031298; GO:0003697 P32354; P29469; P53091; P38132 ATP binding; DNA helicase activity; DNA replication initiation; DNA replication origin binding; DNA replication preinitiation complex; DNA strand elongation involved in DNA replication; DNA unwinding involved in DNA replication; MCM complex; MCM core complex; cytoplasm; double-strand break repair via break-induced replication; nuclear pre-replicative complex; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; replication fork protection complex; single-stranded DNA binding IPR008047; IPR018525; IPR001208; IPR027925; IPR012340; IPR027417; IPR004039; DNA replication licensing factor MCM4 (EC 3.6.4.12) (Cell division control protein 54) MCM4 CDC54 HCD21 YPR019W YP9531.13 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40914_c0_g2_i3 Q6DIH3 MCM2_XENTR 0 GO:0005524; GO:0006200; GO:0003677; GO:0003678; GO:0006270; GO:0006268; GO:0042555; GO:0007049; GO:0000785; GO:0046872; GO:0005634; GO:0030174 ATP binding; ATP catabolic process; DNA binding; DNA helicase activity; DNA replication initiation; DNA unwinding involved in DNA replication; MCM complex; cell cycle; chromatin; metal ion binding; nucleus; regulation of DNA-dependent DNA replication initiation IPR008045; IPR018525; IPR001208; IPR027925; IPR012340; IPR027417; DNA replication licensing factor mcm2 (EC 3.6.4.12) (Minichromosome maintenance protein 2) mcm2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40914_c0_g3_i1 P55861 MCM2_XENLA 4.00E-69 GO:0005524; GO:0006200; GO:0003677; GO:0003678; GO:0006270; GO:0006268; GO:0042555; GO:0007049; GO:0000785; GO:0046872; GO:0005634; GO:0030174 P49739 ATP binding; ATP catabolic process; DNA binding; DNA helicase activity; DNA replication initiation; DNA unwinding involved in DNA replication; MCM complex; cell cycle; chromatin; metal ion binding; nucleus; regulation of DNA-dependent DNA replication initiation IPR008045; IPR018525; IPR001208; IPR027925; IPR012340; IPR027417; DNA replication licensing factor mcm2 (EC 3.6.4.12) (BM28-homolog) (Minichromosome maintenance protein 2) (xMCM2) (p112) mcm2 Xenopus laevis (African clawed frog) TR40916_c1_g1_i2 Q9H7P6 F125B_HUMAN 2.00E-36 GO:0031902; GO:0015031 late endosome membrane; protein transport IPR018798; IPR023341; IPR023340; Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B) MVB12B C9orf28 FAM125B Homo sapiens (Human) TR40917_c2_g1_i1 Q7ZWG6 PCFT_DANRE 2.00E-25 GO:0005542; GO:0016021; GO:0055085 folic acid binding; integral to membrane; transmembrane transport IPR011701; IPR016196; Proton-coupled folate transporter (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1) slc46a1 hcp1 pcft zgc:56400 Danio rerio (Zebrafish) (Brachydanio rerio) TR40917_c2_g1_i2 Q5EBA8 PCFT_RAT 6.00E-20 GO:0016324; GO:0031526; GO:0005737; GO:0005542; GO:0008517; GO:0015232; GO:0016021; GO:0015350; GO:0055085 apical plasma membrane; brush border membrane; cytoplasm; folic acid binding; folic acid transporter activity; heme transporter activity; integral to membrane; methotrexate transporter activity; transmembrane transport IPR011701; IPR020846; IPR016196; IPR005829; Proton-coupled folate transporter (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1) Slc46a1 Hcp1 Pcft Rattus norvegicus (Rat) TR40918_c2_g3_i1 A2AJA7 AEGP_MOUSE 1.00E-15 GO:0016021; GO:0015031 integral to membrane; protein transport IPR008985; IPR023415; IPR002172; IPR000998; Apical endosomal glycoprotein (MAM domain-containing protein 4) Mamdc4 Aegp Gm995 Mus musculus (Mouse) TR40918_c2_g4_i2 O15405 TOX3_HUMAN 2.00E-29 GO:0006915; GO:0003682; GO:0034056; GO:0043524; GO:0005634; GO:0045893; GO:0042803; GO:0006351 "apoptotic process; chromatin binding; estrogen response element binding; negative regulation of neuron apoptotic process; nucleus; positive regulation of transcription, DNA-dependent; protein homodimerization activity; transcription, DNA-dependent" IPR009071; TOX high mobility group box family member 3 (CAG trinucleotide repeat-containing gene F9 protein) (Trinucleotide repeat-containing gene 9 protein) TOX3 CAGF9 TNRC9 Homo sapiens (Human) TR40918_c2_g7_i1 Q0WYX8 MDGA1_CHICK 2.00E-08 GO:0046658; GO:0001764 anchored to plasma membrane; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 MDGA1 Gallus gallus (Chicken) TR40919_c0_g1_i4 P54368 OAZ1_HUMAN 1.00E-23 GO:0005829; GO:0008073; GO:0006596; GO:0006521; GO:0044281 cytosol; ornithine decarboxylase inhibitor activity; polyamine biosynthetic process; regulation of cellular amino acid metabolic process; small molecule metabolic process IPR016181; IPR002993; Ornithine decarboxylase antizyme 1 (ODC-Az) OAZ1 OAZ Homo sapiens (Human) TR40921_c5_g1_i2 Q9NP80 PLPL8_HUMAN 4.00E-125 GO:0005524; GO:0000139; GO:0019369; GO:0050482; GO:0047499; GO:0008219; GO:0005789; GO:0046474; GO:0016021; GO:0043651; GO:0004622; GO:0048471; GO:0005778; GO:0036151; GO:0034638; GO:0036152; GO:0046338; GO:0001516 ATP binding; Golgi membrane; arachidonic acid metabolic process; arachidonic acid secretion; calcium-independent phospholipase A2 activity; cell death; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process; integral to membrane; linoleic acid metabolic process; lysophospholipase activity; perinuclear region of cytoplasm; peroxisomal membrane; phosphatidylcholine acyl-chain remodeling; phosphatidylcholine catabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylethanolamine catabolic process; prostaglandin biosynthetic process IPR016035; IPR002641; Calcium-independent phospholipase A2-gamma (EC 3.1.1.5) (Intracellular membrane-associated calcium-independent phospholipase A2 gamma) (iPLA2-gamma) (PNPLA-gamma) (Patatin-like phospholipase domain-containing protein 8) (iPLA2-2) PNPLA8 IPLA22 IPLA2G BM-043 Homo sapiens (Human) TR40921_c5_g1_i5 Q9NP80 PLPL8_HUMAN 4.00E-125 GO:0005524; GO:0000139; GO:0019369; GO:0050482; GO:0047499; GO:0008219; GO:0005789; GO:0046474; GO:0016021; GO:0043651; GO:0004622; GO:0048471; GO:0005778; GO:0036151; GO:0034638; GO:0036152; GO:0046338; GO:0001516 ATP binding; Golgi membrane; arachidonic acid metabolic process; arachidonic acid secretion; calcium-independent phospholipase A2 activity; cell death; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process; integral to membrane; linoleic acid metabolic process; lysophospholipase activity; perinuclear region of cytoplasm; peroxisomal membrane; phosphatidylcholine acyl-chain remodeling; phosphatidylcholine catabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylethanolamine catabolic process; prostaglandin biosynthetic process IPR016035; IPR002641; Calcium-independent phospholipase A2-gamma (EC 3.1.1.5) (Intracellular membrane-associated calcium-independent phospholipase A2 gamma) (iPLA2-gamma) (PNPLA-gamma) (Patatin-like phospholipase domain-containing protein 8) (iPLA2-2) PNPLA8 IPLA22 IPLA2G BM-043 Homo sapiens (Human) TR40922_c0_g1_i1 Q9P2K8 E2AK4_HUMAN 5.00E-07 GO:0005524; GO:0009267; GO:0022626; GO:0030968; GO:0004694; GO:0017148; GO:0006446; GO:0043558 ATP binding; cellular response to starvation; cytosolic ribosome; endoplasmic reticulum unfolded protein response; eukaryotic translation initiation factor 2alpha kinase activity; negative regulation of translation; regulation of translational initiation; regulation of translational initiation in response to stress IPR004154; IPR024435; IPR011009; IPR000719; IPR017441; IPR006575; IPR008271; IPR016255; IPR016135; Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) EIF2AK4 GCN2 KIAA1338 Homo sapiens (Human) TR40922_c2_g2_i1 Q9QZ05 E2AK4_MOUSE 4.00E-07 GO:0005524; GO:0009267; GO:0022626; GO:0030968; GO:0004694; GO:0017148; GO:0043558 ATP binding; cellular response to starvation; cytosolic ribosome; endoplasmic reticulum unfolded protein response; eukaryotic translation initiation factor 2alpha kinase activity; negative regulation of translation; regulation of translational initiation in response to stress IPR004154; IPR024435; IPR011009; IPR000719; IPR017441; IPR006575; IPR008271; IPR016255; IPR016135; Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2) Eif2ak4 Gcn2 Kiaa1338 Mus musculus (Mouse) TR40922_c4_g2_i1 Q5K2N1 DET2_SOLLC 1.00E-38 GO:0003865; GO:0016132; GO:0047751; GO:0005737; GO:0016021; GO:0050213 3-oxo-5-alpha-steroid 4-dehydrogenase activity; brassinosteroid biosynthetic process; cholestenone 5-alpha-reductase activity; cytoplasm; integral to membrane; progesterone 5-alpha-reductase activity IPR016636; IPR001104; Plant hormone biosynthesis; brassinosteroid biosynthesis. Steroid 5-alpha-reductase DET2 (LeDET2) (EC 1.3.1.22) DET2 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) TR40923_c0_g1_i2 Q8R2S9 ARP8_MOUSE 0 GO:0005524; GO:0006310; GO:0006281; GO:0031011; GO:0051301; GO:0006338; GO:0007067; GO:0006355; GO:0006351 "ATP binding; DNA recombination; DNA repair; Ino80 complex; cell division; chromatin remodeling; mitosis; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR004000; IPR027668; Actin-related protein 8 Actr8 Arp8 Mus musculus (Mouse) TR40923_c0_g1_i3 D2I1E3 ARP8_AILME 0 GO:0005524; GO:0006310; GO:0006281; GO:0031011; GO:0051301; GO:0006338; GO:0007067; GO:0006355; GO:0006351 "ATP binding; DNA recombination; DNA repair; Ino80 complex; cell division; chromatin remodeling; mitosis; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR004000; IPR027668; Actin-related protein 8 ACTR8 ARP8 PANDA_019105 Ailuropoda melanoleuca (Giant panda) TR40923_c0_g1_i5 P38696 ARP1_YEAST 5.00E-10 GO:0005737; GO:0005869; GO:0030286; GO:0000132; GO:0016020; GO:0005874; GO:0003774; GO:0007097; GO:0005200 Q04549; P36224; P33420 cytoplasm; dynactin complex; dynein complex; establishment of mitotic spindle orientation; membrane; microtubule; motor activity; nuclear migration; structural constituent of cytoskeleton IPR004000; IPR020902; Centractin (Actin-like protein) (Actin-related protein 1) ARP1 ACT3 ACT5 YHR129C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR40924_c0_g1_i2 P74148 Y1388_SYNY3 4.00E-08 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein Sll1388 (USP Sll1388) sll1388 Synechocystis sp. (strain PCC 6803 / Kazusa) TR40924_c0_g1_i4 P74148 Y1388_SYNY3 8.00E-09 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein Sll1388 (USP Sll1388) sll1388 Synechocystis sp. (strain PCC 6803 / Kazusa) TR40926_c5_g3_i2 Q9BRZ2 TRI56_HUMAN 3.00E-06 GO:0005829; GO:0051607; GO:0032608; GO:0032481; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytosol; defense response to virus; interferon-beta production; positive regulation of type I interferon production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) TR40926_c5_g3_i7 O08629 TIF1B_RAT 1.00E-06 GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0005719; GO:0005720; GO:0005654; GO:0005634; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006351; GO:0004842; GO:0008270 "DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; nucleus; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (Nuclear corepressor KAP-1) (Tripartite motif-containing protein 28) Trim28 Kap1 Tif1b Rattus norvegicus (Rat) TR40927_c0_g1_i1 B1H3E1 NLK2_XENTR 0 GO:0005524; GO:0004707; GO:0000165; GO:0016055; GO:0009952; GO:0005737; GO:0000287; GO:0001707; GO:0007399; GO:0005634; GO:0018107; GO:0031398; GO:0004674; GO:0006355; GO:0033136; GO:0008134; GO:0006351; GO:0007179; GO:0031625 "ATP binding; MAP kinase activity; MAPK cascade; Wnt receptor signaling pathway; anterior/posterior pattern specification; cytoplasm; magnesium ion binding; mesoderm formation; nervous system development; nucleus; peptidyl-threonine phosphorylation; positive regulation of protein ubiquitination; protein serine/threonine kinase activity; regulation of transcription, DNA-dependent; serine phosphorylation of STAT3 protein; transcription factor binding; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; ubiquitin protein ligase binding" IPR011009; IPR003527; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase NLK2 (EC 2.7.11.24) (Nemo-like kinase 2) (Nlk.2) nlk.2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40927_c0_g1_i2 D3ZSZ3 NLK_RAT 0 GO:0005524; GO:0004707; GO:0016055; GO:0005737; GO:0000287; GO:0030178; GO:0005634; GO:0018107; GO:0046777; GO:0006355; GO:0033136; GO:0006351; GO:0007179 "ATP binding; MAP kinase activity; Wnt receptor signaling pathway; cytoplasm; magnesium ion binding; negative regulation of Wnt receptor signaling pathway; nucleus; peptidyl-threonine phosphorylation; protein autophosphorylation; regulation of transcription, DNA-dependent; serine phosphorylation of STAT3 protein; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway" IPR011009; IPR003527; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) Nlk Rattus norvegicus (Rat) TR40927_c0_g1_i3 D3ZSZ3 NLK_RAT 0 GO:0005524; GO:0004707; GO:0016055; GO:0005737; GO:0000287; GO:0030178; GO:0005634; GO:0018107; GO:0046777; GO:0006355; GO:0033136; GO:0006351; GO:0007179 "ATP binding; MAP kinase activity; Wnt receptor signaling pathway; cytoplasm; magnesium ion binding; negative regulation of Wnt receptor signaling pathway; nucleus; peptidyl-threonine phosphorylation; protein autophosphorylation; regulation of transcription, DNA-dependent; serine phosphorylation of STAT3 protein; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway" IPR011009; IPR003527; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) Nlk Rattus norvegicus (Rat) TR40927_c0_g1_i4 Q5J4W4 MPK2_ORYSJ 6.00E-82 GO:0005524; GO:0004707; GO:0000165; GO:0018108; GO:0004713 ATP binding; MAP kinase activity; MAPK cascade; peptidyl-tyrosine phosphorylation; protein tyrosine kinase activity IPR011009; IPR000719; IPR002290; IPR008266; Mitogen-activated protein kinase 2 (MAP kinase 2) (EC 2.7.11.24) MPK2 Os08g0157000 LOC_Os08g06060 P0438H08.24 Oryza sativa subsp. japonica (Rice) TR40927_c0_g1_i5 Q62407 SPEG_MOUSE 2.00E-14 GO:0005524; GO:0055013; GO:0001701; GO:0005634; GO:0004674; GO:0060541 ATP binding; cardiac muscle cell development; in utero embryonic development; nucleus; protein serine/threonine kinase activity; respiratory system development IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Striated muscle-specific serine/threonine-protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Speg Apeg1 Kiaa1297 Mus musculus (Mouse) TR40927_c0_g1_i6 B1H3E1 NLK2_XENTR 0 GO:0005524; GO:0004707; GO:0000165; GO:0016055; GO:0009952; GO:0005737; GO:0000287; GO:0001707; GO:0007399; GO:0005634; GO:0018107; GO:0031398; GO:0004674; GO:0006355; GO:0033136; GO:0008134; GO:0006351; GO:0007179; GO:0031625 "ATP binding; MAP kinase activity; MAPK cascade; Wnt receptor signaling pathway; anterior/posterior pattern specification; cytoplasm; magnesium ion binding; mesoderm formation; nervous system development; nucleus; peptidyl-threonine phosphorylation; positive regulation of protein ubiquitination; protein serine/threonine kinase activity; regulation of transcription, DNA-dependent; serine phosphorylation of STAT3 protein; transcription factor binding; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; ubiquitin protein ligase binding" IPR011009; IPR003527; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase NLK2 (EC 2.7.11.24) (Nemo-like kinase 2) (Nlk.2) nlk.2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40928_c3_g1_i3 Q9VEX0 SULF1_DROME 2.00E-113 GO:0005795; GO:0009986; GO:0005783; GO:0046872; GO:0008045; GO:0042059; GO:0045879; GO:0045880; GO:0030111; GO:0017015; GO:0008484; GO:0016201 Golgi stack; cell surface; endoplasmic reticulum; metal ion binding; motor neuron axon guidance; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of smoothened signaling pathway; positive regulation of smoothened signaling pathway; regulation of Wnt receptor signaling pathway; regulation of transforming growth factor beta receptor signaling pathway; sulfuric ester hydrolase activity; synaptic target inhibition IPR017849; IPR017850; IPR024609; IPR000917; IPR024607; Extracellular sulfatase SULF-1 homolog (DmSulf-1) (EC 3.1.6.-) Sulf1 CG6725 Drosophila melanogaster (Fruit fly) TR40928_c3_g3_i2 Q9D2L1 ARSK_MOUSE 2.00E-10 GO:0005576; GO:0046872; GO:0008484 extracellular region; metal ion binding; sulfuric ester hydrolase activity IPR017849; IPR017850; IPR000917; Arylsulfatase K (ASK) (EC 3.1.6.-) Arsk Mus musculus (Mouse) TR40928_c3_g3_i4 Q0TUK6 SULF_CLOP1 1.00E-10 GO:0004065; GO:0046872 arylsulfatase activity; metal ion binding IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase (EC 3.1.6.1) (Cys-type sulfatase) CPF_0221 Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A) TR40928_c3_g3_i5 Q8CFG0 SULF2_MOUSE 4.00E-48 GO:0005795; GO:0008449; GO:0004065; GO:0060348; GO:0005509; GO:0009986; GO:0002063; GO:0048706; GO:0005783; GO:0014846; GO:0005615; GO:0035860; GO:0032836; GO:0003094; GO:0030201; GO:0060384; GO:0040037; GO:0005886; GO:0030177; GO:0010575 Golgi stack; N-acetylglucosamine-6-sulfatase activity; arylsulfatase activity; bone development; calcium ion binding; cell surface; chondrocyte development; embryonic skeletal system development; endoplasmic reticulum; esophagus smooth muscle contraction; extracellular space; glial cell-derived neurotrophic factor receptor signaling pathway; glomerular basement membrane development; glomerular filtration; heparan sulfate proteoglycan metabolic process; innervation; negative regulation of fibroblast growth factor receptor signaling pathway; plasma membrane; positive regulation of Wnt receptor signaling pathway; positive regulation vascular endothelial growth factor production IPR017849; IPR017850; IPR014615; IPR024609; IPR000917; IPR024607; Extracellular sulfatase Sulf-2 (mSulf-2) (EC 3.1.6.-) Sulf2 Mus musculus (Mouse) TR40931_c0_g2_i1 P82798 ATRX_MACEU 5.00E-43 GO:0005524; GO:0003677; GO:0006281; GO:0004386; GO:0005634; GO:0008270 ATP binding; DNA binding; DNA repair; helicase activity; nucleus; zinc ion binding IPR025766; IPR011011; IPR001841; IPR013083; Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Fragment) ATRX Macropus eugenii (Tammar wallaby) TR40931_c0_g2_i3 Q7YQM3 ATRX_PONPY 3.00E-44 GO:0005524; GO:0003677; GO:0006281; GO:0004386; GO:0005634; GO:0008270 ATP binding; DNA binding; DNA repair; helicase activity; nucleus; zinc ion binding IPR025766; IPR014001; IPR001650; IPR027417; IPR000330; IPR011011; IPR001841; IPR013083; Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) ATRX Pongo pygmaeus (Bornean orangutan) TR40931_c0_g2_i4 P82798 ATRX_MACEU 5.00E-43 GO:0005524; GO:0003677; GO:0006281; GO:0004386; GO:0005634; GO:0008270 ATP binding; DNA binding; DNA repair; helicase activity; nucleus; zinc ion binding IPR025766; IPR011011; IPR001841; IPR013083; Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Fragment) ATRX Macropus eugenii (Tammar wallaby) TR40931_c1_g1_i1 P46100 ATRX_HUMAN 3.00E-172 GO:0005524; GO:0003677; GO:0003678; GO:0006306; GO:0006310; GO:0006281; GO:0003682; GO:0030900; GO:0005720; GO:0006355; GO:0008270 Q9UER7 "ATP binding; DNA binding; DNA helicase activity; DNA methylation; DNA recombination; DNA repair; chromatin binding; forebrain development; nuclear heterochromatin; regulation of transcription, DNA-dependent; zinc ion binding" IPR025766; IPR014001; IPR001650; IPR027417; IPR000330; IPR011011; IPR001841; IPR013083; Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) ATRX RAD54L XH2 Homo sapiens (Human) TR40931_c1_g1_i2 P46100 ATRX_HUMAN 9.00E-176 GO:0005524; GO:0003677; GO:0003678; GO:0006306; GO:0006310; GO:0006281; GO:0003682; GO:0030900; GO:0005720; GO:0006355; GO:0008270 Q9UER7 "ATP binding; DNA binding; DNA helicase activity; DNA methylation; DNA recombination; DNA repair; chromatin binding; forebrain development; nuclear heterochromatin; regulation of transcription, DNA-dependent; zinc ion binding" IPR025766; IPR014001; IPR001650; IPR027417; IPR000330; IPR011011; IPR001841; IPR013083; Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) ATRX RAD54L XH2 Homo sapiens (Human) TR40931_c1_g1_i3 Q9GQN5 ATRX_DROME 0 GO:0005524; GO:0016887; GO:0003677; GO:0006281; GO:0006336; GO:0007411; GO:0005722; GO:0042585; GO:0008347; GO:0004386; GO:0070868; GO:0097193; GO:0046328 ATP binding; ATPase activity; DNA binding; DNA repair; DNA replication-independent nucleosome assembly; axon guidance; beta-heterochromatin; germinal vesicle; glial cell migration; helicase activity; heterochromatin organization involved in chromatin silencing; intrinsic apoptotic signaling pathway; regulation of JNK cascade IPR014001; IPR001650; IPR027417; IPR000330; Transcriptional regulator ATRX homolog (EC 3.6.4.12) (ATP-dependent helicase XNP) (X-linked nuclear protein) (d-xnp) (dXNP) XNP CG4548 Drosophila melanogaster (Fruit fly) TR40931_c1_g1_i4 Q9Y4B4 ARIP4_HUMAN 4.00E-87 GO:0005524; GO:0003677; GO:0004386; GO:0005634; GO:0003712 ATP binding; DNA binding; helicase activity; nucleus; transcription cofactor activity IPR014001; IPR001650; IPR027417; IPR000330; Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) RAD54L2 ARIP4 KIAA0809 Homo sapiens (Human) TR40931_c1_g1_i5 P46100 ATRX_HUMAN 7.00E-177 GO:0005524; GO:0003677; GO:0003678; GO:0006306; GO:0006310; GO:0006281; GO:0003682; GO:0030900; GO:0005720; GO:0006355; GO:0008270 Q9UER7 "ATP binding; DNA binding; DNA helicase activity; DNA methylation; DNA recombination; DNA repair; chromatin binding; forebrain development; nuclear heterochromatin; regulation of transcription, DNA-dependent; zinc ion binding" IPR025766; IPR014001; IPR001650; IPR027417; IPR000330; IPR011011; IPR001841; IPR013083; Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) ATRX RAD54L XH2 Homo sapiens (Human) TR40931_c1_g1_i6 Q9GQN5 ATRX_DROME 6.00E-130 GO:0005524; GO:0016887; GO:0003677; GO:0006281; GO:0006336; GO:0007411; GO:0005722; GO:0042585; GO:0008347; GO:0004386; GO:0070868; GO:0097193; GO:0046328 ATP binding; ATPase activity; DNA binding; DNA repair; DNA replication-independent nucleosome assembly; axon guidance; beta-heterochromatin; germinal vesicle; glial cell migration; helicase activity; heterochromatin organization involved in chromatin silencing; intrinsic apoptotic signaling pathway; regulation of JNK cascade IPR014001; IPR001650; IPR027417; IPR000330; Transcriptional regulator ATRX homolog (EC 3.6.4.12) (ATP-dependent helicase XNP) (X-linked nuclear protein) (d-xnp) (dXNP) XNP CG4548 Drosophila melanogaster (Fruit fly) TR40932_c0_g2_i1 P52292 IMA2_HUMAN 0 GO:0006259; GO:0006607; GO:0019221; GO:0005829; GO:0000085; GO:0019048; GO:0008139; GO:0005654; GO:0008565; GO:0000018 P38398; O96017; P05412; P03101; P03107; Q6GQG6; P46063; P29034; P06703; Q9UH99 DNA metabolic process; NLS-bearing protein import into nucleus; cytokine-mediated signaling pathway; cytosol; mitotic G2 phase; modulation by virus of host morphology or physiology; nuclear localization sequence binding; nucleoplasm; protein transporter activity; regulation of DNA recombination IPR011989; IPR016024; IPR000225; IPR002652; IPR024931; Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) KPNA2 RCH1 SRP1 Homo sapiens (Human) TR40934_c0_g1_i1 Q8MIM3 NR1I3_MACMU 3.00E-25 GO:0005737; GO:0005856; GO:0005634; GO:0043565; GO:0003707; GO:0004887; GO:0008270 cytoplasm; cytoskeleton; nucleus; sequence-specific DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; zinc ion binding IPR008946; IPR000536; IPR001723; IPR001728; IPR001628; IPR013088; Nuclear receptor subfamily 1 group I member 3 (Constitutive androstane receptor) (CAR) NR1I3 CAR Macaca mulatta (Rhesus macaque) TR40934_c0_g1_i4 P17671 E75BC_DROME 3.00E-47 GO:0003677; GO:0019730; GO:0018990; GO:0035072; GO:0020037; GO:0004879; GO:0005634; GO:0048477; GO:0007553; GO:0043565; GO:0003707; GO:0004887; GO:0008270 "DNA binding; antimicrobial humoral response; ecdysis, chitin-based cuticle; ecdysone-mediated induction of salivary gland cell autophagic cell death; heme binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleus; oogenesis; regulation of ecdysteroid metabolic process; sequence-specific DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001728; IPR001628; IPR013088; "Ecdysone-induced protein 75B, isoforms C/D (E75-A) (Nuclear receptor subfamily 1 group D member 3, isoforms C/D)" Eip75B NR1D3 CG8127 Drosophila melanogaster (Fruit fly) TR40935_c0_g1_i1 Q7ZW78 RN181_DANRE 2.00E-11 GO:0016874; GO:0016567; GO:0008270 ligase activity; protein ubiquitination; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF181 (EC 6.3.2.-) (RING finger protein 181) rnf181 si:ch211-102c2.10 zgc:56424 Danio rerio (Zebrafish) (Brachydanio rerio) TR40935_c1_g2_i3 Q8C4P0 K1958_MOUSE 3.00E-08 IPR021893; Uncharacterized protein KIAA1958 homolog Mus musculus (Mouse) TR40937_c0_g1_i2 P50592 TNF10_MOUSE 2.00E-14 GO:0005615; GO:0006955; GO:0016021; GO:0043123; GO:0043065; GO:0043280; GO:2001238; GO:0090200 extracellular space; immune response; integral to membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of release of cytochrome c from mitochondria IPR021184; IPR006052; IPR017355; IPR008983; Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253) Tnfsf10 Trail Mus musculus (Mouse) TR40937_c0_g1_i4 P50592 TNF10_MOUSE 2.00E-14 GO:0005615; GO:0006955; GO:0016021; GO:0043123; GO:0043065; GO:0043280; GO:2001238; GO:0090200 extracellular space; immune response; integral to membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of release of cytochrome c from mitochondria IPR021184; IPR006052; IPR017355; IPR008983; Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253) Tnfsf10 Trail Mus musculus (Mouse) TR40938_c0_g1_i1 Q80UM3 NAA15_MOUSE 0 GO:0008080; GO:0001525; GO:0030154; GO:0005737; GO:0005634; GO:0048471; GO:0006355; GO:0006351 "N-acetyltransferase activity; angiogenesis; cell differentiation; cytoplasm; nucleus; perinuclear region of cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR021183; IPR013026; IPR011990; IPR013105; IPR019734; "N-alpha-acetyltransferase 15, NatA auxiliary subunit (N-terminal acetyltransferase 1) (NMDA receptor-regulated protein 1) (Protein tubedown-1)" Naa15 Narg1 Nat1 Tbdn-1 Tubedown Mus musculus (Mouse) TR40938_c0_g1_i2 Q6N069 NAA16_HUMAN 0 GO:0006474; GO:0005737; GO:0005634; GO:0045893; GO:0005667 "N-terminal protein amino acid acetylation; cytoplasm; nucleus; positive regulation of transcription, DNA-dependent; transcription factor complex" IPR021183; IPR013026; IPR011990; IPR019734; "N-alpha-acetyltransferase 16, NatA auxiliary subunit (NMDA receptor-regulated 1-like protein) (NARG1-like protein)" NAA16 NARG1L NAT2 Homo sapiens (Human) TR40939_c0_g2_i2 Q42539 PIMT_ARATH 2.00E-12 GO:0007568; GO:0005829; GO:0004719; GO:0009737; GO:0009651; GO:0009845 aging; cytosol; protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; response to abscisic acid stimulus; response to salt stress; seed germination IPR000682; Protein-L-isoaspartate O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) PCM At3g48330 T29H11_150 Arabidopsis thaliana (Mouse-ear cress) TR40939_c0_g2_i3 P59913 PCMD1_MOUSE 1.00E-111 GO:0005737; GO:0004719 cytoplasm; protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IPR000682; Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 Pcmtd1 Mus musculus (Mouse) TR40940_c1_g1_i3 O55043 ARHG7_RAT 2.00E-93 GO:0005089; GO:0043615; GO:0005938; GO:0005737; GO:0005925; GO:0030426; GO:0005085; GO:0030027; GO:0030032; GO:0005543; GO:0043065; GO:0035023; GO:0001726; GO:0007264 P41227; Q13177 Rho guanyl-nucleotide exchange factor activity; astrocyte cell migration; cell cortex; cytoplasm; focal adhesion; growth cone; guanyl-nucleotide exchange factor activity; lamellipodium; lamellipodium assembly; phospholipid binding; positive regulation of apoptotic process; regulation of Rho protein signal transduction; ruffle; small GTPase mediated signal transduction IPR000219; IPR001331; IPR011993; IPR001849; IPR011511; IPR001452; Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) Arhgef7 Pak3bp Pixb Rattus norvegicus (Rat) TR40940_c1_g1_i5 Q5ZLR6 ARHG6_CHICK 2.00E-74 GO:0005089; GO:0005737; GO:0035556; GO:0030027; GO:0030032; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; cytoplasm; intracellular signal transduction; lamellipodium; lamellipodium assembly; phospholipid binding; regulation of Rho protein signal transduction IPR001715; IPR000219; IPR001331; IPR011993; IPR001849; IPR001452; Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) ARHGEF6 RCJMB04_5b15 Gallus gallus (Chicken) TR40940_c1_g1_i6 Q69ZK0 PREX1_MOUSE 1.00E-07 GO:0005089; GO:0005829; GO:0043231; GO:0035556; GO:0005543; GO:0005886; GO:0035023 Rho guanyl-nucleotide exchange factor activity; cytosol; intracellular membrane-bounded organelle; intracellular signal transduction; phospholipid binding; plasma membrane; regulation of Rho protein signal transduction IPR000591; IPR000219; IPR001331; IPR001478; IPR011993; IPR001849; IPR011991; "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1)" Prex1 Kiaa1415 Mus musculus (Mouse) TR40940_c1_g1_i7 Q14155 ARHG7_HUMAN 1.00E-76 GO:0005089; GO:0097190; GO:0005938; GO:0005829; GO:0007173; GO:0005925; GO:0005085; GO:0030027; GO:0030032; GO:0042059; GO:0007399; GO:0043005; GO:0043025; GO:0048011; GO:0005543; GO:0043547; GO:0043065; GO:0043234; GO:0035023; GO:0051056; GO:0001726; GO:0007264 P22681; Q9Y2X7; Q5S007; P41227; Q13153; Q13177; P63000; Q14160; O60880 Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; cell cortex; cytosol; epidermal growth factor receptor signaling pathway; focal adhesion; guanyl-nucleotide exchange factor activity; lamellipodium; lamellipodium assembly; negative regulation of epidermal growth factor receptor signaling pathway; nervous system development; neuron projection; neuronal cell body; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of GTPase activity; positive regulation of apoptotic process; protein complex; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; ruffle; small GTPase mediated signal transduction IPR001715; IPR000219; IPR001331; IPR011993; IPR001849; IPR011511; IPR001452; Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314 Homo sapiens (Human) TR40940_c1_g1_i8 O55043 ARHG7_RAT 8.00E-95 GO:0005089; GO:0043615; GO:0005938; GO:0005737; GO:0005925; GO:0030426; GO:0005085; GO:0030027; GO:0030032; GO:0005543; GO:0043065; GO:0035023; GO:0001726; GO:0007264 P41227; Q13177 Rho guanyl-nucleotide exchange factor activity; astrocyte cell migration; cell cortex; cytoplasm; focal adhesion; growth cone; guanyl-nucleotide exchange factor activity; lamellipodium; lamellipodium assembly; phospholipid binding; positive regulation of apoptotic process; regulation of Rho protein signal transduction; ruffle; small GTPase mediated signal transduction IPR000219; IPR001331; IPR011993; IPR001849; IPR011511; IPR001452; Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) Arhgef7 Pak3bp Pixb Rattus norvegicus (Rat) TR40940_c1_g1_i9 Q5ZLR6 ARHG6_CHICK 2.00E-71 GO:0005089; GO:0005737; GO:0035556; GO:0030027; GO:0030032; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; cytoplasm; intracellular signal transduction; lamellipodium; lamellipodium assembly; phospholipid binding; regulation of Rho protein signal transduction IPR001715; IPR000219; IPR001331; IPR011993; IPR001849; IPR001452; Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) ARHGEF6 RCJMB04_5b15 Gallus gallus (Chicken) TR40940_c1_g3_i2 Q5DU57 SPT13_MOUSE 3.00E-20 GO:0030676; GO:0016477; GO:0005737; GO:0030175; GO:0046847; GO:0035556; GO:0030027; GO:0030032; GO:0005634; GO:0005543; GO:0035023; GO:0030334; GO:0032587 Rac guanyl-nucleotide exchange factor activity; cell migration; cytoplasm; filopodium; filopodium assembly; intracellular signal transduction; lamellipodium; lamellipodium assembly; nucleus; phospholipid binding; regulation of Rho protein signal transduction; regulation of cell migration; ruffle membrane IPR000219; IPR001331; IPR011993; IPR001849; IPR001452; Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2) Spata13 Mus musculus (Mouse) TR40940_c1_g3_i3 Q13009 TIAM1_HUMAN 9.00E-14 GO:0005089; GO:0097190; GO:0005911; GO:0005829; GO:0048013; GO:0048011; GO:0005543; GO:0005886; GO:0043065; GO:0050772; GO:0005057; GO:0035023; GO:0051056; GO:0007264 Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; cell-cell junction; cytosol; ephrin receptor signaling pathway; neurotrophin TRK receptor signaling pathway; phospholipid binding; plasma membrane; positive regulation of apoptotic process; positive regulation of axonogenesis; receptor signaling protein activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR000219; IPR001331; IPR001478; IPR011993; IPR001849; IPR003116; T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1) TIAM1 Homo sapiens (Human) TR40941_c2_g1_i1 Q8BU85 MSRB3_MOUSE 2.00E-57 GO:0005783; GO:0005739; GO:0033743; GO:0030091; GO:0008270 endoplasmic reticulum; mitochondrion; peptide-methionine (R)-S-oxide reductase activity; protein repair; zinc ion binding IPR002579; IPR011057; "Methionine-R-sulfoxide reductase B3, mitochondrial (MsrB3) (EC 1.8.4.-)" Msrb3 Mus musculus (Mouse) TR40942_c4_g2_i1 Q63089 S22A1_RAT 1.00E-46 GO:0005277; GO:0016323; GO:0005329; GO:0015872; GO:0006855; GO:0048241; GO:0010248; GO:0005887; GO:0005333; GO:0015874; GO:0042803; GO:0051260; GO:0015651; GO:0008513 Itself acetylcholine transmembrane transporter activity; basolateral plasma membrane; dopamine transmembrane transporter activity; dopamine transport; drug transmembrane transport; epinephrine transport; establishment or maintenance of transmembrane electrochemical gradient; integral to plasma membrane; norepinephrine transmembrane transporter activity; norepinephrine transport; protein homodimerization activity; protein homooligomerization; quaternary ammonium group transmembrane transporter activity; secondary active organic cation transmembrane transporter activity IPR020846; IPR016196; IPR004749; IPR005828; IPR005829; Solute carrier family 22 member 1 (Organic cation transporter 1) (rOCT1) Slc22a1 Oct1 Rattus norvegicus (Rat) TR40942_c4_g2_i2 Q9VCA2 ORCT_DROME 1.00E-37 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR40942_c4_g2_i5 Q921A2 MYCT_RAT 7.00E-06 GO:0016021; GO:0022891 integral to membrane; substrate-specific transmembrane transporter activity IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13) Slc2a13 Rattus norvegicus (Rat) TR40942_c4_g3_i2 Q5RC45 S22AO_PONAB 3.00E-13 GO:0016021; GO:0006811; GO:0022857 integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Solute carrier family 22 member 24 SLC22A24 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR40942_c4_g3_i4 Q91WU2 S22A7_MOUSE 3.00E-21 GO:0016323; GO:0005887; GO:0008514; GO:0035634 basolateral plasma membrane; integral to plasma membrane; organic anion transmembrane transporter activity; response to stilbenoid IPR020846; IPR016196; IPR004749; IPR005828; Solute carrier family 22 member 7 (Organic anion transporter 2) (mOAT2) Slc22a7 Oat2 Mus musculus (Mouse) TR40943_c1_g2_i2 Q6P1S2 CC033_HUMAN 7.00E-15 GO:0016788; GO:0016021; GO:0003676 "hydrolase activity, acting on ester bonds; integral to membrane; nucleic acid binding" IPR016071; Uncharacterized protein C3orf33 C3orf33 MSTP052 Homo sapiens (Human) TR40944_c0_g1_i1 P45867 ACDA_BACSU 2.00E-92 GO:0003995; GO:0006635; GO:0050660 acyl-CoA dehydrogenase activity; fatty acid beta-oxidation; flavin adenine dinucleotide binding IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Lipid metabolism; fatty acid beta-oxidation. Acyl-CoA dehydrogenase (EC 1.3.99.-) acdA acd BSU37170 Bacillus subtilis (strain 168) TR40944_c0_g1_i2 Q9D7B6 ACAD8_MOUSE 0 GO:0003995; GO:0050660; GO:0005739; GO:0006574 acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; mitochondrion; valine catabolic process IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Amino-acid degradation; L-valine degradation. "Isobutyryl-CoA dehydrogenase, mitochondrial (EC 1.3.99.-) (Acyl-CoA dehydrogenase family member 8) (ACAD-8)" Acad8 Mus musculus (Mouse) TR40946_c0_g1_i2 Q6DCC6 GTPB6_XENLA 9.00E-94 GO:0005525 GTP binding IPR006073; IPR016496; IPR027417; Putative GTP-binding protein 6 gtpbp6 Xenopus laevis (African clawed frog) TR40946_c0_g1_i6 Q6DCC6 GTPB6_XENLA 9.00E-30 GO:0005525 GTP binding IPR006073; IPR016496; IPR027417; Putative GTP-binding protein 6 gtpbp6 Xenopus laevis (African clawed frog) TR40947_c3_g2_i2 P14618 KPYM_HUMAN 0 GO:0005524; GO:0005929; GO:0005829; GO:0070062; GO:0006096; GO:0000287; GO:0005739; GO:0005634; GO:0005886; GO:0030955; GO:0012501; GO:0004743; GO:0044281 Q9WMX2; P49407; P32121; P53355; Q9H6Z9; Q16665; P04049 ATP binding; cilium; cytosol; extracellular vesicular exosome; glycolysis; magnesium ion binding; mitochondrion; nucleus; plasma membrane; potassium ion binding; programmed cell death; pyruvate kinase activity; small molecule metabolic process IPR001697; IPR015813; IPR011037; IPR015794; IPR018209; IPR015793; IPR015795; IPR015806; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (p58) PKM OIP3 PK2 PK3 PKM2 Homo sapiens (Human) TR40947_c3_g2_i3 P11980 KPYM_RAT 3.00E-50 GO:0043531; GO:0005524; GO:0006754; GO:0005737; GO:0006096; GO:0001889; GO:0000287; GO:0005634; GO:0031100; GO:0030955; GO:0042866; GO:0004743; GO:0009629; GO:0001666; GO:0032868; GO:0014870; GO:0007584; GO:0043403 ADP binding; ATP binding; ATP biosynthetic process; cytoplasm; glycolysis; liver development; magnesium ion binding; nucleus; organ regeneration; potassium ion binding; pyruvate biosynthetic process; pyruvate kinase activity; response to gravity; response to hypoxia; response to insulin stimulus; response to muscle inactivity; response to nutrient; skeletal muscle tissue regeneration IPR001697; IPR015813; IPR011037; IPR015794; IPR018209; IPR015793; IPR015795; IPR015806; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. Pyruvate kinase PKM (EC 2.7.1.40) (Pyruvate kinase muscle isozyme) Pkm Pkm2 Pykm Rattus norvegicus (Rat) TR40948_c1_g1_i1 Q5BIP7 LIAS_BOVIN 7.00E-111 GO:0051539; GO:0016992; GO:0046872; GO:0005739 "4 iron, 4 sulfur cluster binding; lipoate synthase activity; metal ion binding; mitochondrion" IPR013785; IPR006638; IPR003698; IPR007197; Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2. "Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate synthase) (LS) (Lip-syn) (Lipoic acid synthase)" LIAS Bos taurus (Bovine) TR40948_c1_g1_i5 C3Y3G4 LIAS_BRAFL 2.00E-102 GO:0051539; GO:0016992; GO:0046872; GO:0005739 "4 iron, 4 sulfur cluster binding; lipoate synthase activity; metal ion binding; mitochondrion" IPR013785; IPR006638; IPR003698; IPR007197; Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2. "Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate synthase) (LS) (Lip-syn) (Lipoic acid synthase)" BRAFLDRAFT_125969 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR40948_c1_g1_i6 Q2LYK1 LIAS_DROPS 2.00E-102 GO:0051539; GO:0016992; GO:0046872; GO:0005739 "4 iron, 4 sulfur cluster binding; lipoate synthase activity; metal ion binding; mitochondrion" IPR013785; IPR006638; IPR003698; IPR007197; Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2. "Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate synthase) (LS) (Lip-syn) (Lipoic acid synthase)" Las GA18753 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR40948_c1_g5_i1 C3Y3G4 LIAS_BRAFL 1.00E-27 GO:0051539; GO:0016992; GO:0046872; GO:0005739 "4 iron, 4 sulfur cluster binding; lipoate synthase activity; metal ion binding; mitochondrion" IPR013785; IPR006638; IPR003698; IPR007197; Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2. "Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate synthase) (LS) (Lip-syn) (Lipoic acid synthase)" BRAFLDRAFT_125969 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR40948_c1_g5_i2 B3SBB5 LIAS_TRIAD 5.00E-31 GO:0051539; GO:0016992; GO:0046872; GO:0005739 "4 iron, 4 sulfur cluster binding; lipoate synthase activity; metal ion binding; mitochondrion" IPR013785; IPR006638; IPR003698; IPR007197; Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2. "Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate synthase) (LS) (Lip-syn) (Lipoic acid synthase)" TRIADDRAFT_38449 Trichoplax adhaerens (Trichoplax reptans) TR40948_c1_g6_i3 B4MXR6 LIAS_DROWI 5.00E-28 GO:0051539; GO:0016992; GO:0046872; GO:0005739 "4 iron, 4 sulfur cluster binding; lipoate synthase activity; metal ion binding; mitochondrion" IPR013785; IPR006638; IPR003698; IPR007197; Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2. "Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate synthase) (LS) (Lip-syn) (Lipoic acid synthase)" Las GK17689 Drosophila willistoni (Fruit fly) TR40950_c0_g3_i1 Q8VC31 CCDC9_MOUSE 9.00E-21 Coiled-coil domain-containing protein 9 Ccdc9 Mus musculus (Mouse) TR40953_c0_g1_i1 Q9XGA1 KPRS4_SPIOL 2.00E-78 GO:0005524; GO:0005737; GO:0016301; GO:0000287; GO:0009116; GO:0009165; GO:0004749 ATP binding; cytoplasm; kinase activity; magnesium ion binding; nucleoside metabolic process; nucleotide biosynthetic process; ribose phosphate diphosphokinase activity IPR000836; IPR005946; Ribose-phosphate pyrophosphokinase 4 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 4) PRS4 Spinacia oleracea (Spinach) TR40953_c0_g1_i3 Q9XGA0 KPRS3_SPIOL 5.00E-79 GO:0005524; GO:0016301; GO:0000287; GO:0005739; GO:0009116; GO:0009165; GO:0004749 ATP binding; kinase activity; magnesium ion binding; mitochondrion; nucleoside metabolic process; nucleotide biosynthetic process; ribose phosphate diphosphokinase activity IPR000836; IPR005946; "Ribose-phosphate pyrophosphokinase 3, mitochondrial (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 3)" PRS3 Spinacia oleracea (Spinach) TR40955_c4_g1_i1 Q9Y6L7 TLL2_HUMAN 0 GO:0005509; GO:0030154; GO:0030198; GO:0005576; GO:0004222; GO:0007275; GO:0006508; GO:0008270 calcium ion binding; cell differentiation; extracellular matrix organization; extracellular region; metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Tolloid-like protein 2 (EC 3.4.24.-) TLL2 KIAA0932 Homo sapiens (Human) TR40955_c4_g1_i3 Q9DER7 TLL1_CHICK 0 GO:0005509; GO:0030154; GO:0005576; GO:0004222; GO:0007275; GO:0006508; GO:0008270 calcium ion binding; cell differentiation; extracellular region; metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Tolloid-like protein 1 (EC 3.4.24.-) (Chicken tolloid-like protein 1) (Metalloprotease colloid) TLL1 Gallus gallus (Chicken) TR40955_c4_g1_i4 O57460 TLL1_DANRE 0 GO:0001568; GO:0005509; GO:0048264; GO:0035124; GO:0035162; GO:0001885; GO:0005576; GO:0001707; GO:0004222; GO:0008237; GO:0030513; GO:0036342; GO:0006508; GO:0008270 blood vessel development; calcium ion binding; determination of ventral identity; embryonic caudal fin morphogenesis; embryonic hemopoiesis; endothelial cell development; extracellular region; mesoderm formation; metalloendopeptidase activity; metallopeptidase activity; positive regulation of BMP signaling pathway; post-anal tail morphogenesis; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Dorsal-ventral patterning tolloid-like protein 1 (EC 3.4.24.-) (Mini fin protein) tll1 mfn tld tolloid Danio rerio (Zebrafish) (Brachydanio rerio) TR40957_c1_g1_i1 Q6IE26 EPHX4_MOUSE 1.00E-72 GO:0016787; GO:0016021; GO:0008152 hydrolase activity; integral to membrane; metabolic process IPR000073; IPR000639; Epoxide hydrolase 4 (EC 3.3.-.-) (Abhydrolase domain-containing protein 7) (Epoxide hydrolase-related protein) Ephx4 Abhd7 Ephxrp Mus musculus (Mouse) TR40959_c5_g1_i1 Q8NI08 NCOA7_HUMAN 2.00E-83 GO:0016998; GO:0005622; GO:0030374; GO:0035257; GO:0005634; GO:0045944; GO:0006351 P35869; P27540; O95166; Q9H0R8 "cell wall macromolecule catabolic process; intracellular; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR018392; IPR006571; Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) NCOA7 ERAP140 ESNA1 Nbla00052 Nbla10993 Homo sapiens (Human) TR40959_c5_g1_i2 A8KBE0 OXR1_XENTR 4.00E-77 GO:0016998; GO:0005739; GO:0006950 cell wall macromolecule catabolic process; mitochondrion; response to stress IPR018392; IPR006571; Oxidation resistance protein 1 oxr1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40959_c6_g1_i1 Q5ZMS4 NCOA7_CHICK 1.00E-22 GO:0016998; GO:0005634; GO:0006355; GO:0006351 "cell wall macromolecule catabolic process; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR018392; IPR006571; Nuclear receptor coactivator 7 NCOA7 RCJMB04_1f5 Gallus gallus (Chicken) TR40960_c0_g1_i3 P48612 PELO_DROME 1.00E-119 GO:0001745; GO:0005737; GO:0004519; GO:0048132; GO:0030718; GO:0007141; GO:0008315; GO:0051078; GO:0000212; GO:0046872; GO:0007067; GO:0090305; GO:0005634; GO:0048137 compound eye morphogenesis; cytoplasm; endonuclease activity; female germ-line stem cell division; germ-line stem cell maintenance; male meiosis I; meiotic G2/MI transition; meiotic nuclear envelope disassembly; meiotic spindle organization; metal ion binding; mitosis; nucleic acid phosphodiester bond hydrolysis; nucleus; spermatocyte division IPR005140; IPR005141; IPR005142; IPR004405; Protein pelota (EC 3.1.-.-) pelo CG3959 Drosophila melanogaster (Fruit fly) TR40960_c0_g2_i2 Q5ZK01 PELO_CHICK 3.00E-50 GO:0007049; GO:0051301; GO:0005737; GO:0004519; GO:0046872; GO:0090305; GO:0005634 cell cycle; cell division; cytoplasm; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleus IPR005140; IPR005141; IPR005142; IPR004405; Protein pelota homolog (EC 3.1.-.-) PELO RCJMB04_14b4 Gallus gallus (Chicken) TR40960_c0_g3_i1 B8GIR5 PELO_METPE 4.00E-08 GO:0005737; GO:0004519; GO:0046872; GO:0090305 cytoplasm; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR005140; IPR005141; IPR005142; IPR004405; IPR023521; Protein pelota homolog (EC 3.1.-.-) pelA Mpal_1565 Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c) TR40960_c0_g3_i2 P48612 PELO_DROME 3.00E-57 GO:0001745; GO:0005737; GO:0004519; GO:0048132; GO:0030718; GO:0007141; GO:0008315; GO:0051078; GO:0000212; GO:0046872; GO:0007067; GO:0090305; GO:0005634; GO:0048137 compound eye morphogenesis; cytoplasm; endonuclease activity; female germ-line stem cell division; germ-line stem cell maintenance; male meiosis I; meiotic G2/MI transition; meiotic nuclear envelope disassembly; meiotic spindle organization; metal ion binding; mitosis; nucleic acid phosphodiester bond hydrolysis; nucleus; spermatocyte division IPR005140; IPR005141; IPR005142; IPR004405; Protein pelota (EC 3.1.-.-) pelo CG3959 Drosophila melanogaster (Fruit fly) TR40962_c0_g1_i1 P70398 USP9X_MOUSE 0 GO:0030509; GO:0045177; GO:0051301; GO:0007059; GO:0070410; GO:0008234; GO:0005737; GO:0007067; GO:0016579; GO:0007179; GO:0004221; GO:0006511 A5PKW4; Q13485 BMP signaling pathway; apical part of cell; cell division; chromosome segregation; co-SMAD binding; cysteine-type peptidase activity; cytoplasm; mitosis; protein deubiquitination; transforming growth factor beta receptor signaling pathway; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR016024; IPR018200; IPR001394; "Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets homolog) (Fat facets protein-related, X-linked) (Ubiquitin carboxyl-terminal hydrolase FAM) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)" Usp9x Fafl Fam Mus musculus (Mouse) TR40962_c0_g1_i2 Q9FPS4 UBP23_ARATH 5.00E-17 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 23 (EC 3.4.19.12) (Deubiquitinating enzyme 23) (AtUBP23) (Ubiquitin thioesterase 23) (Ubiquitin-specific-processing protease 23) UBP23 At5g57990 MTI20.25 Arabidopsis thaliana (Mouse-ear cress) TR40962_c0_g1_i3 P70398 USP9X_MOUSE 0 GO:0030509; GO:0045177; GO:0051301; GO:0007059; GO:0070410; GO:0008234; GO:0005737; GO:0007067; GO:0016579; GO:0007179; GO:0004221; GO:0006511 A5PKW4; Q13485 BMP signaling pathway; apical part of cell; cell division; chromosome segregation; co-SMAD binding; cysteine-type peptidase activity; cytoplasm; mitosis; protein deubiquitination; transforming growth factor beta receptor signaling pathway; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR016024; IPR018200; IPR001394; "Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets homolog) (Fat facets protein-related, X-linked) (Ubiquitin carboxyl-terminal hydrolase FAM) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)" Usp9x Fafl Fam Mus musculus (Mouse) TR40962_c0_g4_i1 Q9FPS4 UBP23_ARATH 5.00E-17 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 23 (EC 3.4.19.12) (Deubiquitinating enzyme 23) (AtUBP23) (Ubiquitin thioesterase 23) (Ubiquitin-specific-processing protease 23) UBP23 At5g57990 MTI20.25 Arabidopsis thaliana (Mouse-ear cress) TR40962_c0_g4_i2 Q5I043 UBP28_MOUSE 6.00E-06 GO:0000077; GO:0006281; GO:0008283; GO:0034644; GO:0042771; GO:0005730; GO:0005654; GO:0043234; GO:0016579; GO:0010212; GO:0004221; GO:0006511; GO:0004843 DNA damage checkpoint; DNA repair; cell proliferation; cellular response to UV; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; nucleolus; nucleoplasm; protein complex; protein deubiquitination; response to ionizing radiation; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR018200; IPR001394; IPR009060; IPR003903; Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) Usp28 Kiaa1515 Mus musculus (Mouse) TR40962_c0_g4_i4 P70398 USP9X_MOUSE 0 GO:0030509; GO:0045177; GO:0051301; GO:0007059; GO:0070410; GO:0008234; GO:0005737; GO:0007067; GO:0016579; GO:0007179; GO:0004221; GO:0006511 A5PKW4; Q13485 BMP signaling pathway; apical part of cell; cell division; chromosome segregation; co-SMAD binding; cysteine-type peptidase activity; cytoplasm; mitosis; protein deubiquitination; transforming growth factor beta receptor signaling pathway; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR016024; IPR018200; IPR001394; "Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets homolog) (Fat facets protein-related, X-linked) (Ubiquitin carboxyl-terminal hydrolase FAM) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)" Usp9x Fafl Fam Mus musculus (Mouse) TR40962_c0_g4_i6 P70398 USP9X_MOUSE 3.00E-45 GO:0030509; GO:0045177; GO:0051301; GO:0007059; GO:0070410; GO:0008234; GO:0005737; GO:0007067; GO:0016579; GO:0007179; GO:0004221; GO:0006511 A5PKW4; Q13485 BMP signaling pathway; apical part of cell; cell division; chromosome segregation; co-SMAD binding; cysteine-type peptidase activity; cytoplasm; mitosis; protein deubiquitination; transforming growth factor beta receptor signaling pathway; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR016024; IPR018200; IPR001394; "Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets homolog) (Fat facets protein-related, X-linked) (Ubiquitin carboxyl-terminal hydrolase FAM) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)" Usp9x Fafl Fam Mus musculus (Mouse) TR40963_c0_g1_i1 Q99666 RGPD5_HUMAN 1.00E-28 GO:0005737; GO:0000042 cytoplasm; protein targeting to Golgi IPR000237; IPR011993; IPR000156; IPR013026; IPR011990; IPR001440; IPR019734; RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) RGPD5 RANBP2L1 RGP5 RGP7 RGPD7; RGPD6 RANBP2L2 RGP6 Homo sapiens (Human) TR40963_c0_g1_i2 Q9ERU9 RBP2_MOUSE 5.00E-32 GO:0046907; GO:0016874; GO:0051028; GO:0005739; GO:0033132; GO:0042405; GO:0031965; GO:0044615; GO:0003755; GO:0006457; GO:0000413; GO:0016925; GO:0015031; GO:0090526; GO:0008270 Q9WVS6 intracellular transport; ligase activity; mRNA transport; mitochondrion; negative regulation of glucokinase activity; nuclear inclusion body; nuclear membrane; nuclear pore nuclear basket; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization; protein sumoylation; protein transport; regulation of gluconeogenesis involved in cellular glucose homeostasis; zinc ion binding IPR002130; IPR020892; IPR022011; IPR011993; IPR000156; IPR013026; IPR011990; IPR001440; IPR019734; IPR001876; Protein modification; protein sumoylation. E3 SUMO-protein ligase RanBP2 (EC 6.3.2.-) (Ran-binding protein 2) (RanBP2) Ranbp2 Mus musculus (Mouse) TR40963_c0_g1_i3 Q8RWG8 RBP1B_ARATH 8.00E-26 GO:0046907; GO:0051028; GO:0005643; GO:0015031 intracellular transport; mRNA transport; nuclear pore; protein transport IPR011993; IPR000156; Ran-binding protein 1 homolog b RANBP1B At2g30060 F23F1.1 T27E13.20 Arabidopsis thaliana (Mouse-ear cress) TR40963_c0_g1_i4 P43487 RANG_HUMAN 4.00E-52 GO:0005092; GO:0005096; GO:0008536; GO:0005813; GO:0005737; GO:0046907; GO:0005635; GO:0043547; GO:0046604; GO:0007165; GO:0007051; GO:0016032 P29372 GDP-dissociation inhibitor activity; GTPase activator activity; Ran GTPase binding; centrosome; cytoplasm; intracellular transport; nuclear envelope; positive regulation of GTPase activity; positive regulation of mitotic centrosome separation; signal transduction; spindle organization; viral process IPR011993; IPR000156; Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) RANBP1 Homo sapiens (Human) TR40963_c0_g1_i6 P43487 RANG_HUMAN 7.00E-54 GO:0005092; GO:0005096; GO:0008536; GO:0005813; GO:0005737; GO:0046907; GO:0005635; GO:0043547; GO:0046604; GO:0007165; GO:0007051; GO:0016032 P29372 GDP-dissociation inhibitor activity; GTPase activator activity; Ran GTPase binding; centrosome; cytoplasm; intracellular transport; nuclear envelope; positive regulation of GTPase activity; positive regulation of mitotic centrosome separation; signal transduction; spindle organization; viral process IPR011993; IPR000156; Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) RANBP1 Homo sapiens (Human) TR40964_c3_g5_i1 O13016 PTN1_CHICK 1.00E-116 GO:0031532; GO:0005769; GO:0005789; GO:0030968; GO:0004725; GO:0030100; GO:0009966 P10288 actin cytoskeleton reorganization; early endosome; endoplasmic reticulum membrane; endoplasmic reticulum unfolded protein response; protein tyrosine phosphatase activity; regulation of endocytosis; regulation of signal transduction IPR012265; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (CPTP1) (Protein-tyrosine phosphatase 1B) (PTP-1B) PTPN1 PTP1B Gallus gallus (Chicken) TR40964_c3_g5_i2 O13016 PTN1_CHICK 5.00E-119 GO:0031532; GO:0005769; GO:0005789; GO:0030968; GO:0004725; GO:0030100; GO:0009966 P10288 actin cytoskeleton reorganization; early endosome; endoplasmic reticulum membrane; endoplasmic reticulum unfolded protein response; protein tyrosine phosphatase activity; regulation of endocytosis; regulation of signal transduction IPR012265; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (CPTP1) (Protein-tyrosine phosphatase 1B) (PTP-1B) PTPN1 PTP1B Gallus gallus (Chicken) TR40965_c0_g1_i2 O55096 DPP3_RAT 0 GO:0004177; GO:0005737; GO:0008239; GO:0008237; GO:0006508; GO:0008270 aminopeptidase activity; cytoplasm; dipeptidyl-peptidase activity; metallopeptidase activity; proteolysis; zinc ion binding IPR005317; Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) Dpp3 Rattus norvegicus (Rat) TR40967_c7_g2_i4 P17178 CP27A_RAT 4.00E-13 GO:0047749; GO:0031073; GO:0008203; GO:0020037; GO:0005506; GO:0005740; GO:0005743; GO:0006706; GO:0030343 cholestanetriol 26-monooxygenase activity; cholesterol 26-hydroxylase activity; cholesterol metabolic process; heme binding; iron ion binding; mitochondrial envelope; mitochondrial inner membrane; steroid catabolic process; vitamin D3 25-hydroxylase activity IPR001128; IPR017972; IPR002401; Hormone biosynthesis; cholecalciferol biosynthesis. "Sterol 26-hydroxylase, mitochondrial (EC 1.14.13.15) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase) (Cytochrome P-450C27/25) (Cytochrome P450 27) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase)" Cyp27a1 Cyp27 Rattus norvegicus (Rat) TR40969_c1_g2_i3 O75970 MPDZ_HUMAN 5.00E-57 GO:0043220; GO:0016324; GO:0016327; GO:0007155; GO:0005737; GO:0031410; GO:0030425; GO:0019048; GO:0042552; GO:0014069; GO:0045211; GO:0005923 Q9H205; Q9HB21; Q9ERS5; P32745; P04637 Schmidt-Lanterman incisure; apical plasma membrane; apicolateral plasma membrane; cell adhesion; cytoplasm; cytoplasmic vesicle; dendrite; modulation by virus of host morphology or physiology; myelination; postsynaptic density; postsynaptic membrane; tight junction IPR004172; IPR015132; IPR001478; Multiple PDZ domain protein (Multi-PDZ domain protein 1) MPDZ MUPP1 Homo sapiens (Human) TR40970_c0_g1_i1 Q9EQG6 KDIS_RAT 1.00E-174 GO:0030165; GO:0016482; GO:0005829; GO:0016021; GO:0005770; GO:0038180; GO:0010976; GO:0043234; GO:0019901; GO:0019887 P46109 PDZ domain binding; cytoplasmic transport; cytosol; integral to membrane; late endosome; nerve growth factor signaling pathway; positive regulation of neuron projection development; protein complex; protein kinase binding; protein kinase regulator activity IPR002110; IPR020683; IPR011646; IPR013761; Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) Kidins220 Arms Rattus norvegicus (Rat) TR40970_c0_g1_i2 Q9EQG6 KDIS_RAT 9.00E-175 GO:0030165; GO:0016482; GO:0005829; GO:0016021; GO:0005770; GO:0038180; GO:0010976; GO:0043234; GO:0019901; GO:0019887 P46109 PDZ domain binding; cytoplasmic transport; cytosol; integral to membrane; late endosome; nerve growth factor signaling pathway; positive regulation of neuron projection development; protein complex; protein kinase binding; protein kinase regulator activity IPR002110; IPR020683; IPR011646; IPR013761; Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) Kidins220 Arms Rattus norvegicus (Rat) TR40970_c1_g2_i2 Q17RQ9 NKPD1_HUMAN 2.00E-26 GO:0016021 integral to membrane IPR011646; NTPase KAP family P-loop domain-containing protein 1 NKPD1 Homo sapiens (Human) TR40970_c1_g2_i3 Q9EQG6 KDIS_RAT 6.00E-50 GO:0030165; GO:0016482; GO:0005829; GO:0016021; GO:0005770; GO:0038180; GO:0010976; GO:0043234; GO:0019901; GO:0019887 P46109 PDZ domain binding; cytoplasmic transport; cytosol; integral to membrane; late endosome; nerve growth factor signaling pathway; positive regulation of neuron projection development; protein complex; protein kinase binding; protein kinase regulator activity IPR002110; IPR020683; IPR011646; IPR013761; Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) Kidins220 Arms Rattus norvegicus (Rat) TR40971_c1_g1_i1 Q3TYX3 SMYD5_MOUSE 1.00E-09 GO:0046872; GO:0008168 metal ion binding; methyltransferase activity IPR001214; SET and MYND domain-containing protein 5 (EC 2.1.1.-) (Protein NN8-4AG) (Retinoic acid-induced protein 15) Smyd5 Rai15 Mus musculus (Mouse) TR40971_c1_g1_i2 Q5ZIZ2 SMYD5_CHICK 6.00E-12 GO:0046872; GO:0008168 metal ion binding; methyltransferase activity IPR001214; IPR002893; SET and MYND domain-containing protein 5 (EC 2.1.1.-) SMYD5 RCJMB04_22j23 Gallus gallus (Chicken) TR40971_c1_g1_i3 Q5PP37 ATXR2_ARATH 9.00E-10 GO:0034968; GO:0018024; GO:0046872; GO:0005634 histone lysine methylation; histone-lysine N-methyltransferase activity; metal ion binding; nucleus IPR001214; IPR002893; Histone-lysine N-methyltransferase ATXR2 (EC 2.1.1.43) (Protein SET DOMAIN GROUP 36) (Trithorax-related protein 2) (TRX-related protein 2) ATXR2 SDG36 SET36 At3g21820 MSD21.13 Arabidopsis thaliana (Mouse-ear cress) TR40975_c2_g3_i1 Q81TU1 PRSA2_BACAN 2.00E-06 GO:0003755; GO:0005886; GO:0006457; GO:0000413 peptidyl-prolyl cis-trans isomerase activity; plasma membrane; protein folding; protein peptidyl-prolyl isomerization IPR023059; IPR000297; IPR023058; IPR027304; Foldase protein PrsA 2 (EC 5.2.1.8) prsA2 prsA-2 BA_1169 GBAA_1169 BAS1084 Bacillus anthracis TR40975_c2_g3_i4 Q94G00 PIN1_MALDO 1.00E-23 GO:0003755; GO:0006457; GO:0000413 peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR000297; IPR023058; Peptidyl-prolyl cis-trans isomerase Pin1 (PPIase Pin1) (EC 5.2.1.8) (MdPin1) (Rotamase Pin1) PIN1 Malus domestica (Apple) (Pyrus malus) TR40975_c2_g3_i5 Q94G00 PIN1_MALDO 1.00E-27 GO:0003755; GO:0006457; GO:0000413 peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR000297; IPR023058; Peptidyl-prolyl cis-trans isomerase Pin1 (PPIase Pin1) (EC 5.2.1.8) (MdPin1) (Rotamase Pin1) PIN1 Malus domestica (Apple) (Pyrus malus) TR40975_c2_g3_i6 Q9SL42 PIN1_ARATH 9.00E-24 GO:0005829; GO:0005783; GO:0003755; GO:0005886; GO:0009506; GO:0006457; GO:0051726 O82794; O64645 cytosol; endoplasmic reticulum; peptidyl-prolyl cis-trans isomerase activity; plasma membrane; plasmodesma; protein folding; regulation of cell cycle IPR000297; IPR023058; Peptidyl-prolyl cis-trans isomerase Pin1 (PPIase Pin1) (EC 5.2.1.8) (PIN1At) (Rotamase Pin1) PIN1 At2g18040 T27K22.9 Arabidopsis thaliana (Mouse-ear cress) TR40975_c2_g4_i2 P54353 DOD_DROME 3.00E-33 GO:0007173; GO:0005634; GO:0003755; GO:0006457 epidermal growth factor receptor signaling pathway; nucleus; peptidyl-prolyl cis-trans isomerase activity; protein folding IPR000297; IPR023058; IPR001202; Putative peptidyl-prolyl cis-trans isomerase dodo (PPIase dodo) (EC 5.2.1.8) (Rotamase dodo) dod CG17051 Drosophila melanogaster (Fruit fly) TR40976_c0_g1_i2 Q6INN8 SAMH1_XENLA 4.00E-96 GO:0003723; GO:0051607; GO:0045087; GO:0008152; GO:0046872; GO:0005634; GO:0008081; GO:0045088 RNA binding; defense response to virus; innate immune response; metabolic process; metal ion binding; nucleus; phosphoric diester hydrolase activity; regulation of innate immune response IPR003607; IPR006674; IPR001660; IPR013761; IPR011510; Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) samhd1 Xenopus laevis (African clawed frog) TR40976_c0_g1_i4 Q502K2 SAMH1_DANRE 1.00E-92 GO:0003723; GO:0051607; GO:0045087; GO:0008152; GO:0046872; GO:0005634; GO:0008081; GO:0045088 RNA binding; defense response to virus; innate immune response; metabolic process; metal ion binding; nucleus; phosphoric diester hydrolase activity; regulation of innate immune response IPR003607; IPR006674; IPR001660; IPR013761; IPR011510; Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) samhd1 Danio rerio (Zebrafish) (Brachydanio rerio) TR40976_c0_g1_i6 Q0VCA5 SAMH1_BOVIN 8.00E-87 GO:0003723; GO:0051607; GO:0045087; GO:0008152; GO:0046872; GO:0005634; GO:0008081; GO:0045088 RNA binding; defense response to virus; innate immune response; metabolic process; metal ion binding; nucleus; phosphoric diester hydrolase activity; regulation of innate immune response IPR003607; IPR006674; IPR013761; Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) SAMHD1 Bos taurus (Bovine) TR40976_c0_g2_i1 Q5ZJL9 SAMH1_CHICK 1.00E-94 GO:0003723; GO:0051607; GO:0045087; GO:0008152; GO:0046872; GO:0005634; GO:0008081; GO:0045088 RNA binding; defense response to virus; innate immune response; metabolic process; metal ion binding; nucleus; phosphoric diester hydrolase activity; regulation of innate immune response IPR003607; IPR006674; Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) SAMHD1 RCJMB04_17d8 Gallus gallus (Chicken) TR40976_c0_g2_i2 Q9Y3Z3 SAMH1_HUMAN 1.00E-92 GO:0003723; GO:0051607; GO:0006955; GO:0045087; GO:0008152; GO:0046872; GO:0005634; GO:0008081; GO:0045088 O75923; P58753 RNA binding; defense response to virus; immune response; innate immune response; metabolic process; metal ion binding; nucleus; phosphoric diester hydrolase activity; regulation of innate immune response IPR003607; IPR006674; IPR001660; IPR013761; IPR011510; Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) SAMHD1 MOP5 Homo sapiens (Human) TR40976_c0_g2_i3 Q5ZJL9 SAMH1_CHICK 4.00E-95 GO:0003723; GO:0051607; GO:0045087; GO:0008152; GO:0046872; GO:0005634; GO:0008081; GO:0045088 RNA binding; defense response to virus; innate immune response; metabolic process; metal ion binding; nucleus; phosphoric diester hydrolase activity; regulation of innate immune response IPR003607; IPR006674; Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) SAMHD1 RCJMB04_17d8 Gallus gallus (Chicken) TR40976_c0_g2_i6 P39651 YWFO_BACSU 7.00E-20 GO:0008152; GO:0046872; GO:0008081 metabolic process; metal ion binding; phosphoric diester hydrolase activity IPR003607; IPR006674; Uncharacterized protein YwfO ywfO BSU37600 ipa-93d Bacillus subtilis (strain 168) TR40977_c1_g1_i1 Q5ZIR1 SHLB1_CHICK 1.00E-105 GO:0051084; GO:0000139; GO:0006915; GO:0005504; GO:0042171; GO:0005741; GO:0006654; GO:1900740; GO:0043234 'de novo' posttranslational protein folding; Golgi membrane; apoptotic process; fatty acid binding; lysophosphatidic acid acyltransferase activity; mitochondrial outer membrane; phosphatidic acid biosynthetic process; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; protein complex IPR027267; IPR004148; IPR001452; Endophilin-B1 (SH3 domain-containing GRB2-like protein B1) SH3GLB1 RCJMB04_24b23 Gallus gallus (Chicken) TR40977_c1_g1_i2 Q6AYE2 SHLB1_RAT 2.00E-106 GO:0051084; GO:0000139; GO:0006915; GO:0005504; GO:0042171; GO:0005741; GO:0006654; GO:1900740; GO:0043234 'de novo' posttranslational protein folding; Golgi membrane; apoptotic process; fatty acid binding; lysophosphatidic acid acyltransferase activity; mitochondrial outer membrane; phosphatidic acid biosynthetic process; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; protein complex IPR027267; IPR004148; IPR001452; Endophilin-B1 (SH3 domain-containing GRB2-like protein B1) Sh3glb1 Rattus norvegicus (Rat) TR40977_c1_g1_i3 Q99961 SH3G1_HUMAN 3.00E-18 GO:0030054; GO:0042995; GO:0007417; GO:0005737; GO:0031901; GO:0006897; GO:0008289; GO:0002102; GO:0007165 Itself; Q7L190; Q9H788; Q99962; Q99963 cell junction; cell projection; central nervous system development; cytoplasm; early endosome membrane; endocytosis; lipid binding; podosome; signal transduction IPR027267; IPR004148; IPR000108; IPR001452; Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) SH3GL1 CNSA1 SH3D2B Homo sapiens (Human) TR40977_c1_g1_i4 Q6AYE2 SHLB1_RAT 2.00E-106 GO:0051084; GO:0000139; GO:0006915; GO:0005504; GO:0042171; GO:0005741; GO:0006654; GO:1900740; GO:0043234 'de novo' posttranslational protein folding; Golgi membrane; apoptotic process; fatty acid binding; lysophosphatidic acid acyltransferase activity; mitochondrial outer membrane; phosphatidic acid biosynthetic process; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; protein complex IPR027267; IPR004148; IPR001452; Endophilin-B1 (SH3 domain-containing GRB2-like protein B1) Sh3glb1 Rattus norvegicus (Rat) TR40978_c2_g1_i2 Q3UY23 FDXA1_MOUSE 3.00E-49 GO:0005524; GO:0000287; GO:0004826; GO:0006432; GO:0000049; GO:0008033 ATP binding; magnesium ion binding; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding; tRNA processing IPR019446; IPR005121; Ferredoxin-fold anticodon-binding domain-containing protein 1 homolog (FDX-ACDB domain-containing protein 1) Fdxacb1 Mus musculus (Mouse) TR40978_c2_g1_i4 Q3UY23 FDXA1_MOUSE 3.00E-52 GO:0005524; GO:0000287; GO:0004826; GO:0006432; GO:0000049; GO:0008033 ATP binding; magnesium ion binding; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding; tRNA processing IPR019446; IPR005121; Ferredoxin-fold anticodon-binding domain-containing protein 1 homolog (FDX-ACDB domain-containing protein 1) Fdxacb1 Mus musculus (Mouse) TR40979_c0_g1_i2 P51869 CP4F4_RAT 5.00E-101 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 4F4 (EC 1.14.14.1) (CYPIVF4) Cyp4f4 Rattus norvegicus (Rat) TR40979_c1_g1_i1 Q7M3K2 PELET_DROME 2.00E-16 GO:0015074; GO:0003693; GO:0046872; GO:0016740; GO:0004803; GO:0006313 "DNA integration; P-element binding; metal ion binding; transferase activity; transposase activity; transposition, DNA-mediated" IPR022242; IPR021896; IPR006612; Transposable element P transposase (P-element transposase) (EC 2.7.7.-) (THAP domain-containing protein) (DmTHAP) T Drosophila melanogaster (Fruit fly) TR40980_c0_g1_i1 Q8WVT3 TPC12_HUMAN 6.00E-89 GO:0005793; GO:0016192 endoplasmic reticulum-Golgi intermediate compartment; vesicle-mediated transport IPR013026; IPR011990; IPR001440; IPR019734; Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) TRAPPC12 TTC15 CGI-87 Homo sapiens (Human) TR40982_c1_g2_i1 Q8N328 PGBD3_HUMAN 3.00E-10 PiggyBac transposable element-derived protein 3 PGBD3 Homo sapiens (Human) TR40982_c1_g2_i3 Q96DM1 PGBD4_HUMAN 8.00E-13 PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) TR40982_c2_g3_i1 Q8N414 PGBD5_HUMAN 2.00E-11 GO:0016021 integral to membrane PiggyBac transposable element-derived protein 5 PGBD5 Homo sapiens (Human) TR40982_c2_g3_i4 Q8N414 PGBD5_HUMAN 7.00E-12 GO:0016021 integral to membrane PiggyBac transposable element-derived protein 5 PGBD5 Homo sapiens (Human) TR40984_c0_g1_i1 Q94887 NRX4_DROME 4.00E-73 GO:0008366; GO:0061343; GO:0007391; GO:0060857; GO:0007163; GO:0003015; GO:0005887; GO:0021682; GO:0005919; GO:0048786; GO:0097105; GO:0008104; GO:0035151; GO:0019991; GO:0008039; GO:0016081; GO:0016080; GO:0072553 "axon ensheathment; cell adhesion involved in heart morphogenesis; dorsal closure; establishment of glial blood-brain barrier; establishment or maintenance of cell polarity; heart process; integral to plasma membrane; nerve maturation; pleated septate junction; presynaptic active zone; presynaptic membrane assembly; protein localization; regulation of tube size, open tracheal system; septate junction assembly; synaptic target recognition; synaptic vesicle docking involved in exocytosis; synaptic vesicle targeting; terminal button organization" IPR000421; IPR008985; IPR013320; IPR000742; IPR008979; IPR001791; IPR003585; Neurexin-4 (Neurexin IV) Nrx-IV Nrx CG6827 Drosophila melanogaster (Fruit fly) TR40984_c1_g2_i1 Q94887 NRX4_DROME 7.00E-105 GO:0008366; GO:0061343; GO:0007391; GO:0060857; GO:0007163; GO:0003015; GO:0005887; GO:0021682; GO:0005919; GO:0048786; GO:0097105; GO:0008104; GO:0035151; GO:0019991; GO:0008039; GO:0016081; GO:0016080; GO:0072553 "axon ensheathment; cell adhesion involved in heart morphogenesis; dorsal closure; establishment of glial blood-brain barrier; establishment or maintenance of cell polarity; heart process; integral to plasma membrane; nerve maturation; pleated septate junction; presynaptic active zone; presynaptic membrane assembly; protein localization; regulation of tube size, open tracheal system; septate junction assembly; synaptic target recognition; synaptic vesicle docking involved in exocytosis; synaptic vesicle targeting; terminal button organization" IPR000421; IPR008985; IPR013320; IPR000742; IPR008979; IPR001791; IPR003585; Neurexin-4 (Neurexin IV) Nrx-IV Nrx CG6827 Drosophila melanogaster (Fruit fly) TR40984_c1_g3_i1 A1XQX0 NR1AA_DANRE 2.00E-16 GO:0007155; GO:0016021; GO:0046872; GO:0007269; GO:0051965; GO:0090129; GO:0007416 cell adhesion; integral to membrane; metal ion binding; neurotransmitter secretion; positive regulation of synapse assembly; positive regulation of synapse maturation; synapse assembly IPR008985; IPR013320; IPR000742; IPR001791; IPR003585; IPR027158; IPR027789; Neurexin-1a (Neurexin Ia-alpha) (Neurexin-1a-alpha) nrxn1a Danio rerio (Zebrafish) (Brachydanio rerio) TR40984_c1_g3_i2 O70244 CUBN_RAT 4.00E-06 GO:0031526; GO:0005509; GO:0008203; GO:0031419; GO:0030666; GO:0010008; GO:0030492; GO:0020028; GO:0042802; GO:0001701; GO:0043202; GO:0005765; GO:0043234; GO:0070207; GO:0004872; GO:0006898; GO:0007584; GO:0006766 Itself brush border membrane; calcium ion binding; cholesterol metabolic process; cobalamin binding; endocytic vesicle membrane; endosome membrane; hemoglobin binding; hemoglobin import; identical protein binding; in utero embryonic development; lysosomal lumen; lysosomal membrane; protein complex; protein homotrimerization; receptor activity; receptor-mediated endocytosis; response to nutrient; vitamin metabolic process IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; Cubilin (460 kDa receptor) (Glycoprotein 280) (gp280) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) Cubn Ifcr Rattus norvegicus (Rat) TR40986_c1_g1_i1 Q8IR79 LIMK1_DROME 2.00E-12 GO:0005524; GO:0030036; GO:0005826; GO:0032154; GO:0048749; GO:0001737; GO:0030496; GO:0048812; GO:0004674; GO:0050770; GO:0051124; GO:0008270 ATP binding; actin cytoskeleton organization; actomyosin contractile ring; cleavage furrow; compound eye development; establishment of imaginal disc-derived wing hair orientation; midbody; neuron projection morphogenesis; protein serine/threonine kinase activity; regulation of axonogenesis; synaptic growth at neuromuscular junction; zinc ion binding IPR011009; IPR001478; IPR000719; IPR017441; IPR001781; LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1) (dLIMK) LIMK1 LIMK CG1848 Drosophila melanogaster (Fruit fly) TR40986_c1_g1_i11 Q174I2 PRIC1_AEDAE 6.00E-22 GO:0009948; GO:0001736; GO:0005886; GO:0008270 anterior/posterior axis specification; establishment of planar polarity; plasma membrane; zinc ion binding IPR010442; IPR001781; Protein prickle pk AAEL006891 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR40986_c1_g1_i14 Q9PW72 PDLI4_CHICK 1.00E-13 GO:0008270 zinc ion binding IPR001478; IPR001781; PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein) PDLIM4 RIL Gallus gallus (Chicken) TR40986_c1_g1_i15 A1ZA47 ZASP_DROME 5.00E-65 GO:0030018; GO:0015629; GO:0051371; GO:0005927; GO:0030239; GO:0001952; GO:0008270 Z disc; actin cytoskeleton; muscle alpha-actinin binding; muscle tendon junction; myofibril assembly; regulation of cell-matrix adhesion; zinc ion binding IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) TR40986_c1_g1_i16 A1ZA47 ZASP_DROME 4.00E-66 GO:0030018; GO:0015629; GO:0051371; GO:0005927; GO:0030239; GO:0001952; GO:0008270 Z disc; actin cytoskeleton; muscle alpha-actinin binding; muscle tendon junction; myofibril assembly; regulation of cell-matrix adhesion; zinc ion binding IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) TR40986_c1_g1_i17 Q174I2 PRIC1_AEDAE 2.00E-19 GO:0009948; GO:0001736; GO:0005886; GO:0008270 anterior/posterior axis specification; establishment of planar polarity; plasma membrane; zinc ion binding IPR010442; IPR001781; Protein prickle pk AAEL006891 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR40986_c1_g1_i18 Q0VA45 ZYX_XENTR 4.00E-12 GO:0007155; GO:0005737; GO:0005925; GO:0006357; GO:0001725; GO:0008134; GO:0006351; GO:0008270 "cell adhesion; cytoplasm; focal adhesion; regulation of transcription from RNA polymerase II promoter; stress fiber; transcription factor binding; transcription, DNA-dependent; zinc ion binding" IPR001781; Zyxin zyx Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR40986_c1_g1_i2 A1ZA47 ZASP_DROME 3.00E-67 GO:0030018; GO:0015629; GO:0051371; GO:0005927; GO:0030239; GO:0001952; GO:0008270 Z disc; actin cytoskeleton; muscle alpha-actinin binding; muscle tendon junction; myofibril assembly; regulation of cell-matrix adhesion; zinc ion binding IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) TR40986_c1_g1_i3 Q174I2 PRIC1_AEDAE 1.00E-21 GO:0009948; GO:0001736; GO:0005886; GO:0008270 anterior/posterior axis specification; establishment of planar polarity; plasma membrane; zinc ion binding IPR010442; IPR001781; Protein prickle pk AAEL006891 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR40986_c1_g1_i4 Q53GG5 PDLI3_HUMAN 1.00E-12 GO:0030018; GO:0015629; GO:0007015; GO:0007507; GO:0008307; GO:0008270 P49792 Z disc; actin cytoskeleton; actin filament organization; heart development; structural constituent of muscle; zinc ion binding IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) PDLIM3 ALP Homo sapiens (Human) TR40986_c1_g1_i8 A1ZA47 ZASP_DROME 3.00E-67 GO:0030018; GO:0015629; GO:0051371; GO:0005927; GO:0030239; GO:0001952; GO:0008270 Z disc; actin cytoskeleton; muscle alpha-actinin binding; muscle tendon junction; myofibril assembly; regulation of cell-matrix adhesion; zinc ion binding IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) TR40986_c1_g1_i9 Q9PW72 PDLI4_CHICK 1.00E-13 GO:0008270 zinc ion binding IPR001478; IPR001781; PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein) PDLIM4 RIL Gallus gallus (Chicken) TR40988_c3_g2_i1 Q8JHV9 BIR7A_XENLA 5.00E-26 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR40988_c3_g2_i4 Q6R7C4 IAP4_OSHVF 6.00E-10 GO:0008270 zinc ion binding IPR001370; IPR001841; IPR013083; Putative apoptosis inhibitor ORF106 ORF106 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) TR40988_c3_g3_i3 P41436 IAP_GVCPM 6.00E-26 GO:0006915; GO:0008270 apoptotic process; zinc ion binding IPR001370; IPR001841; Apoptosis inhibitor IAP IAP Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) TR40988_c3_g3_i4 P41437 IAP3_NPVOP 9.00E-27 GO:0006915; GO:0016874; GO:0039648; GO:0008270 apoptotic process; ligase activity; modulation by virus of host protein ubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; E3 ubiquitin-protein ligase IAP-3 (EC 6.3.2.-) (IAP-3) IAP3 IAP ORF35 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) TR40990_c1_g2_i2 Q865F1 MTP_PIG 9.00E-97 GO:0005783; GO:0008289; GO:0005319 endoplasmic reticulum; lipid binding; lipid transporter activity IPR015819; IPR001747; IPR015816; IPR011030; Microsomal triglyceride transfer protein large subunit MTTP MTP Sus scrofa (Pig) TR40993_c0_g1_i1 Q9VQ79 AIFM1_DROME 9.00E-52 GO:0006915; GO:0045454; GO:0050832; GO:0010623; GO:0050660; GO:0042775; GO:0005758; GO:0016491 apoptotic process; cell redox homeostasis; defense response to fungus; developmental programmed cell death; flavin adenine dinucleotide binding; mitochondrial ATP synthesis coupled electron transport; mitochondrial intermembrane space; oxidoreductase activity IPR016156; IPR013027; IPR004099; IPR023753; IPR001327; "Putative apoptosis-inducing factor 1, mitochondrial (DmAIF) (EC 1.1.1.-)" AIF CG7263 Drosophila melanogaster (Fruit fly) TR40993_c1_g1_i1 Q7KVW5 KCNN_DROME 4.00E-39 GO:0016021; GO:0009881; GO:0016057; GO:0016286 integral to membrane; photoreceptor activity; regulation of membrane potential in photoreceptor cell; small conductance calcium-activated potassium channel activity IPR013099; IPR004178; IPR015449; Small conductance calcium-activated potassium channel protein (Protein SK) (dSK) SK CG10706 Drosophila melanogaster (Fruit fly) TR40993_c1_g4_i1 Q7KVW5 KCNN_DROME 7.00E-159 GO:0016021; GO:0009881; GO:0016057; GO:0016286 integral to membrane; photoreceptor activity; regulation of membrane potential in photoreceptor cell; small conductance calcium-activated potassium channel activity IPR013099; IPR004178; IPR015449; Small conductance calcium-activated potassium channel protein (Protein SK) (dSK) SK CG10706 Drosophila melanogaster (Fruit fly) TR40995_c0_g1_i1 P70705 ATP7A_RAT 0 GO:0005524; GO:0005794; GO:0016323; GO:0031526; GO:0019829; GO:0006878; GO:0005507; GO:0006825; GO:0001701; GO:0016021; GO:0007595; GO:0005770; GO:0048471; GO:0051353; GO:0046688; GO:0010041; GO:0010043; GO:0030141; GO:0005802; GO:0030140 ATP binding; Golgi apparatus; basolateral plasma membrane; brush border membrane; cation-transporting ATPase activity; cellular copper ion homeostasis; copper ion binding; copper ion transport; in utero embryonic development; integral to membrane; lactation; late endosome; perinuclear region of cytoplasm; positive regulation of oxidoreductase activity; response to copper ion; response to iron(III) ion; response to zinc ion; secretory granule; trans-Golgi network; trans-Golgi network transport vesicle IPR023299; IPR018303; IPR008250; IPR027256; IPR001757; IPR023214; IPR017969; IPR006121; IPR006122; Copper-transporting ATPase 1 (EC 3.6.3.54) (Copper pump 1) (Menkes disease-associated protein homolog) Atp7a Mnk Rattus norvegicus (Rat) TR40995_c0_g3_i2 P13113 MERP_SERMA 2.00E-06 GO:0045340; GO:0015097; GO:0042597 mercury ion binding; mercury ion transmembrane transporter activity; periplasmic space IPR017969; IPR006121; IPR001802; IPR011795; Mercuric transport protein periplasmic component (Mercury scavenger protein) (Periplasmic mercury ion-binding protein) merP Serratia marcescens TR41000_c0_g2_i1 Q8BVU5 NUDT9_MOUSE 3.00E-86 GO:0046032; GO:0047631; GO:0046709; GO:0043262; GO:0005739 ADP catabolic process; ADP-ribose diphosphatase activity; IDP catabolic process; adenosine-diphosphatase activity; mitochondrion IPR000086; IPR015797; "ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9)" Nudt9 Mus musculus (Mouse) TR41001_c1_g2_i3 Q9SA78 COPE1_ARATH 1.00E-70 GO:0030663; GO:0015031; GO:0006890; GO:0005198; GO:0005774 "COPI-coated vesicle membrane; protein transport; retrograde vesicle-mediated transport, Golgi to ER; structural molecule activity; vacuolar membrane" IPR006822; IPR011990; Coatomer subunit epsilon-1 (Epsilon-coat protein 1) (Epsilon-COP 1) At1g30630 T5I8.8 Arabidopsis thaliana (Mouse-ear cress) TR41001_c1_g2_i4 Q5ZIK9 COPE_CHICK 4.00E-140 GO:0030663; GO:0015031; GO:0006890; GO:0005198 "COPI-coated vesicle membrane; protein transport; retrograde vesicle-mediated transport, Golgi to ER; structural molecule activity" IPR006822; IPR011990; Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) COPE RCJMB04_25f12 Gallus gallus (Chicken) TR41001_c1_g2_i7 Q9SA78 COPE1_ARATH 2.00E-70 GO:0030663; GO:0015031; GO:0006890; GO:0005198; GO:0005774 "COPI-coated vesicle membrane; protein transport; retrograde vesicle-mediated transport, Golgi to ER; structural molecule activity; vacuolar membrane" IPR006822; IPR011990; Coatomer subunit epsilon-1 (Epsilon-coat protein 1) (Epsilon-COP 1) At1g30630 T5I8.8 Arabidopsis thaliana (Mouse-ear cress) TR41001_c1_g2_i9 Q5ZIK9 COPE_CHICK 2.00E-139 GO:0030663; GO:0015031; GO:0006890; GO:0005198 "COPI-coated vesicle membrane; protein transport; retrograde vesicle-mediated transport, Golgi to ER; structural molecule activity" IPR006822; IPR011990; Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) COPE RCJMB04_25f12 Gallus gallus (Chicken) TR41004_c0_g1_i1 A0JMQ0 BOP1_DANRE 0 GO:0070545; GO:0000463; GO:0005654; GO:0051726 "PeBoW complex; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleoplasm; regulation of cell cycle" IPR012953; IPR015943; IPR001680; IPR019775; IPR017986; Ribosome biogenesis protein bop1 (Block of proliferation 1 protein) bop1 si:ch211-251g8.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR41004_c0_g1_i2 Q4QH39 BOP1_LEIMA 4.00E-51 GO:0005730; GO:0005654; GO:0006364 nucleolus; nucleoplasm; rRNA processing IPR012953; IPR015943; IPR001680; IPR017986; Ribosome biogenesis protein BOP1 homolog LmjF11.0410 LmjF_11_0410 Leishmania major TR41004_c0_g2_i2 Q4QH39 BOP1_LEIMA 5.00E-14 GO:0005730; GO:0005654; GO:0006364 nucleolus; nucleoplasm; rRNA processing IPR012953; IPR015943; IPR001680; IPR017986; Ribosome biogenesis protein BOP1 homolog LmjF11.0410 LmjF_11_0410 Leishmania major TR41004_c0_g2_i3 A4IHS2 BOP1_XENTR 1.00E-41 GO:0070545; GO:0000463; GO:0005654; GO:0051726 "PeBoW complex; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleoplasm; regulation of cell cycle" IPR012953; IPR015943; IPR001680; IPR019775; IPR017986; Ribosome biogenesis protein bop1 (Block of proliferation 1 protein) bop1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41005_c2_g1_i2 Q86YJ7 AN13B_HUMAN 0 GO:0005769; GO:0005770; GO:0005886 early endosome; late endosome; plasma membrane IPR021832; IPR002110; IPR020683; IPR003903; Ankyrin repeat domain-containing protein 13B ANKRD13B Homo sapiens (Human) TR41005_c2_g1_i4 Q5F259 AN13B_MOUSE 0 GO:0005769; GO:0005770; GO:0005886 early endosome; late endosome; plasma membrane IPR021832; IPR002110; IPR020683; IPR003903; Ankyrin repeat domain-containing protein 13B Ankrd13b Mus musculus (Mouse) TR41005_c2_g1_i5 Q86YJ7 AN13B_HUMAN 0 GO:0005769; GO:0005770; GO:0005886 early endosome; late endosome; plasma membrane IPR021832; IPR002110; IPR020683; IPR003903; Ankyrin repeat domain-containing protein 13B ANKRD13B Homo sapiens (Human) TR41007_c1_g1_i1 Q32LP2 RADI_BOVIN 0 GO:0051693; GO:0032154; GO:0005737; GO:0005856; GO:0019898; GO:0005886 actin filament capping; cleavage furrow; cytoplasm; cytoskeleton; extrinsic to membrane; plasma membrane IPR019749; IPR019750; IPR011174; IPR011259; IPR000798; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR008954; IPR011993; Radixin RDX Bos taurus (Bovine) TR41007_c1_g1_i2 P26043 RADI_MOUSE 0 GO:0051693; GO:0045177; GO:0045176; GO:0032154; GO:0005737; GO:0005856; GO:0019898; GO:0030175; GO:0005925; GO:0030027; GO:0030033; GO:0005886; GO:0001726; GO:0032420 actin filament capping; apical part of cell; apical protein localization; cleavage furrow; cytoplasm; cytoskeleton; extrinsic to membrane; filopodium; focal adhesion; lamellipodium; microvillus assembly; plasma membrane; ruffle; stereocilium IPR019749; IPR019750; IPR011174; IPR011259; IPR000798; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR008954; IPR011993; Radixin (ESP10) Rdx Mus musculus (Mouse) TR41008_c1_g1_i2 P30728 DRD3_MOUSE 2.00E-11 GO:0002031; GO:0046717; GO:0007191; GO:0007195; GO:0045177; GO:0048148; GO:0042995; GO:0032922; GO:0035240; GO:0001591; GO:0008144; GO:0030139; GO:0005887; GO:0007626; GO:0050883; GO:0007194; GO:0045776; GO:0060160; GO:0048715; GO:0051898; GO:0032416; GO:0000122; GO:0005886; GO:0008284; GO:0060161; GO:0045840; GO:0035815; GO:0045944; GO:0002016; GO:0045187; GO:0014059; GO:0019216; GO:0040012; GO:0040014; GO:0001975; GO:0042220; GO:0042493; GO:0045471; GO:0043278; GO:0001963; GO:0008542 "G-protein coupled receptor internalization; acid secretion; adenylate cyclase-activating dopamine receptor signaling pathway; adenylate cyclase-inhibiting dopamine receptor signaling pathway; apical part of cell; behavioral response to cocaine; cell projection; circadian regulation of gene expression; dopamine binding; dopamine neurotransmitter receptor activity, coupled via Gi/Go; drug binding; endocytic vesicle; integral to plasma membrane; locomotory behavior; musculoskeletal movement, spinal reflex action; negative regulation of adenylate cyclase activity; negative regulation of blood pressure; negative regulation of dopamine receptor signaling pathway; negative regulation of oligodendrocyte differentiation; negative regulation of protein kinase B signaling cascade; negative regulation of sodium:hydrogen antiporter activity; negative regulation of transcription from RNA polymerase II promoter; plasma membrane; positive regulation of cell proliferation; positive regulation of dopamine receptor signaling pathway; positive regulation of mitosis; positive regulation of renal sodium excretion; positive regulation of transcription from RNA polymerase II promoter; regulation of blood volume by renin-angiotensin; regulation of circadian sleep/wake cycle, sleep; regulation of dopamine secretion; regulation of lipid metabolic process; regulation of locomotion; regulation of multicellular organism growth; response to amphetamine; response to cocaine; response to drug; response to ethanol; response to morphine; synaptic transmission, dopaminergic; visual learning" IPR001620; IPR000929; IPR000276; IPR017452; D(3) dopamine receptor (Dopamine D3 receptor) Drd3 Mus musculus (Mouse) TR41008_c1_g1_i3 P49683 PRLHR_HUMAN 9.00E-08 GO:0007631; GO:0007565; GO:0042445; GO:0005887; GO:0004983; GO:0008188 Q9Y3R0 feeding behavior; female pregnancy; hormone metabolic process; integral to plasma membrane; neuropeptide Y receptor activity; neuropeptide receptor activity IPR000276; IPR017452; IPR001402; Prolactin-releasing peptide receptor (PrRP receptor) (PrRPR) (G-protein coupled receptor 10) (hGR3) PRLHR GPR10 GR3 Homo sapiens (Human) TR41008_c1_g1_i4 Q9QYN8 HRH3_RAT 5.00E-22 GO:0007420; GO:0042756; GO:0008144; GO:0042755; GO:0007204; GO:0004969; GO:0016021; GO:0007612; GO:0007613; GO:0043209; GO:0007194; GO:0045776; GO:0014053; GO:0014050; GO:0014063; GO:0043005; GO:0005886; GO:0050679; GO:0001505; GO:0014061; GO:0014070 brain development; drinking behavior; drug binding; eating behavior; elevation of cytosolic calcium ion concentration; histamine receptor activity; integral to membrane; learning; memory; myelin sheath; negative regulation of adenylate cyclase activity; negative regulation of blood pressure; negative regulation of gamma-aminobutyric acid secretion; negative regulation of glutamate secretion; negative regulation of serotonin secretion; neuron projection; plasma membrane; positive regulation of epithelial cell proliferation; regulation of neurotransmitter levels; regulation of norepinephrine secretion; response to organic cyclic compound IPR000276; IPR017452; IPR003980; Histamine H3 receptor (H3R) (HH3R) Hrh3 Rattus norvegicus (Rat) TR41008_c1_g2_i1 P28285 5HT2A_DROME 5.00E-11 GO:0001586; GO:0007198; GO:0007615; GO:0016021; GO:0007208; GO:0005886; GO:0045187 "Gi/o-coupled serotonin receptor activity; adenylate cyclase-inhibiting serotonin receptor signaling pathway; anesthesia-resistant memory; integral to membrane; phospholipase C-activating serotonin receptor signaling pathway; plasma membrane; regulation of circadian sleep/wake cycle, sleep" IPR000276; IPR017452; 5-hydroxytryptamine receptor 2A (5-HT receptor 2A) (Serotonin receptor 2A) 5-HT1A 5HT-R2A CG16720 Drosophila melanogaster (Fruit fly) TR41008_c1_g2_i2 Q25190 5HTR_HELVI 2.00E-09 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR000276; IPR017452; 5-hydroxytryptamine receptor (5-HT receptor) (Serotonin receptor) Heliothis virescens (Tobacco budworm moth) TR41009_c0_g1_i2 Q7ZXV3 ARP2B_XENLA 0 GO:0005524; GO:0034314; GO:0005885; GO:0042995; GO:0005737 ATP binding; Arp2/3 complex-mediated actin nucleation; Arp2/3 protein complex; cell projection; cytoplasm IPR004000; IPR020902; IPR027306; Actin-related protein 2-B (Actin-like protein 2-B) actr2-b arp2-b Xenopus laevis (African clawed frog) TR41010_c1_g2_i2 Q8VHF0 MARK3_RAT 2.00E-59 GO:0005524; GO:0005886; GO:0004674 ATP binding; plasma membrane; protein serine/threonine kinase activity IPR028375; IPR001772; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR015940; MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) Mark3 Rattus norvegicus (Rat) TR41010_c1_g4_i1 Q06850 CDPK1_ARATH 1.00E-40 GO:0005524; GO:0005509; GO:0005778; GO:0005777; GO:0046777; GO:0004674 ATP binding; calcium ion binding; peroxisomal membrane; peroxisome; protein autophosphorylation; protein serine/threonine kinase activity IPR011992; IPR018247; IPR002048; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium-dependent protein kinase 1 (AtCDPK 1) (CDPK 1) (EC 2.7.11.1) (Calcium-dependent protein kinase isoform AK1) CPK1 AK1 At5g04870 MUK11.19 Arabidopsis thaliana (Mouse-ear cress) TR41010_c1_g4_i2 Q54DF2 MRKA_DICDI 1.00E-94 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR028375; IPR001772; IPR011009; IPR000719; IPR017441; IPR002290; IPR015940; Probable serine/threonine-protein kinase MARK-A (EC 2.7.11.1) mrkA DDB_G0292304 Dictyostelium discoideum (Slime mold) TR41010_c1_g4_i3 Q03141 MARK3_MOUSE 0 GO:0005524; GO:0005886; GO:0004674 ATP binding; plasma membrane; protein serine/threonine kinase activity IPR028375; IPR001772; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR015940; MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (ELKL motif kinase 2) (EMK-2) (MPK-10) Mark3 Emk2 Mpk10 Mus musculus (Mouse) TR41010_c1_g4_i4 Q03141 MARK3_MOUSE 0 GO:0005524; GO:0005886; GO:0004674 ATP binding; plasma membrane; protein serine/threonine kinase activity IPR028375; IPR001772; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR015940; MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (ELKL motif kinase 2) (EMK-2) (MPK-10) Mark3 Emk2 Mpk10 Mus musculus (Mouse) TR41013_c2_g1_i1 Q96KP1 EXOC2_HUMAN 5.00E-145 GO:0044267; GO:0006887; GO:0005886; GO:0015031 cellular protein metabolic process; exocytosis; plasma membrane; protein transport IPR013783; IPR014756; IPR002909; Exocyst complex component 2 (Exocyst complex component Sec5) EXOC2 SEC5 SEC5L1 Homo sapiens (Human) TR41013_c2_g2_i3 O54921 EXOC2_RAT 7.00E-67 GO:0000145; GO:0006887; GO:0015031 P11233 exocyst; exocytosis; protein transport IPR013783; IPR014756; IPR002909; Exocyst complex component 2 (Exocyst complex component Sec5) (rSec5) Exoc2 Sec5 Sec5l1 Rattus norvegicus (Rat) TR41015_c1_g1_i1 P08548 LIN1_NYCCO 1.00E-08 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR41015_c2_g1_i1 Q9CZJ2 HS12B_MOUSE 7.00E-55 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR41015_c2_g1_i4 Q87WP0 DNAK_PSESM 7.00E-06 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK PSPTO_4505 Pseudomonas syringae pv. tomato (strain DC3000) TR41015_c2_g1_i6 P20163 HSP7D_CAEEL 1.00E-08 GO:0005524; GO:0009790; GO:0034663; GO:0005788; GO:0030968 ATP binding; embryo development; endoplasmic reticulum chaperone complex; endoplasmic reticulum lumen; endoplasmic reticulum unfolded protein response IPR018181; IPR013126; Heat shock 70 kDa protein D hsp-4 hsp70d F43E2.8 Caenorhabditis elegans TR41015_c2_g1_i7 Q9CZJ2 HS12B_MOUSE 2.00E-94 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR41016_c1_g2_i1 Q5RET6 T184C_PONAB 8.00E-120 GO:0016021 integral to membrane IPR005178; Transmembrane protein 184C (Transmembrane protein 34) TMEM184C TMEM34 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41016_c1_g2_i5 Q5RET6 T184C_PONAB 2.00E-14 GO:0016021 integral to membrane IPR005178; Transmembrane protein 184C (Transmembrane protein 34) TMEM184C TMEM34 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41017_c0_g1_i1 Q8K363 DDX18_MOUSE 0 GO:0005524; GO:0008026; GO:0003723; GO:0005730 ATP binding; ATP-dependent helicase activity; RNA binding; nucleolus IPR011545; IPR025313; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) Ddx18 Mus musculus (Mouse) TR41017_c0_g1_i2 Q9NVP1 DDX18_HUMAN 0 GO:0005524; GO:0004004; GO:0003723; GO:0005730 ATP binding; ATP-dependent RNA helicase activity; RNA binding; nucleolus IPR011545; IPR025313; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb) DDX18 Homo sapiens (Human) TR41019_c0_g1_i1 Q05187 TGMH_TACTR 1.00E-58 GO:0016020; GO:0046872; GO:0018149; GO:0003810 membrane; metal ion binding; peptide cross-linking; protein-glutamine gamma-glutamyltransferase activity IPR023608; IPR013783; IPR014756; IPR002931; IPR008958; IPR013808; IPR001102; Hemocyte protein-glutamine gamma-glutamyltransferase (EC 2.3.2.13) (Hemocyte transglutaminase) (TGase) Tachypleus tridentatus (Japanese horseshoe crab) TR41019_c4_g1_i1 Q24352 GBRAL_DROME 9.00E-22 GO:0004890; GO:0005261; GO:0030054; GO:0005254; GO:0034707; GO:0016933; GO:0016021; GO:0005886; GO:0045211 GABA-A receptor activity; cation channel activity; cell junction; chloride channel activity; chloride channel complex; extracellular-glycine-gated ion channel activity; integral to membrane; plasma membrane; postsynaptic membrane IPR006028; IPR006202; IPR006201; IPR006029; IPR018000; Gamma-aminobutyric acid receptor alpha-like (GABA(A) receptor alpha-like and glycine receptor-like subunit of Drosophila) (GRD) Grd CG7446 Drosophila melanogaster (Fruit fly) TR41019_c5_g1_i1 P21548 GBRG2_CHICK 3.00E-25 GO:0004890; GO:0030534; GO:0030424; GO:0030054; GO:0005254; GO:0034707; GO:0005230; GO:0007214; GO:0009791; GO:0045211; GO:0007268 GABA-A receptor activity; adult behavior; axon; cell junction; chloride channel activity; chloride channel complex; extracellular ligand-gated ion channel activity; gamma-aminobutyric acid signaling pathway; post-embryonic development; postsynaptic membrane; synaptic transmission IPR006028; IPR005439; IPR005437; IPR006202; IPR006201; IPR006029; IPR018000; Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2) GABRG2 Gallus gallus (Chicken) TR41020_c3_g1_i1 Q8N1I0 DOCK4_HUMAN 2.00E-132 GO:0030675; GO:0048365; GO:0060326; GO:0005829; GO:0012505; GO:0005085; GO:0016020; GO:0007264; GO:0032420 Rac GTPase activator activity; Rac GTPase binding; cell chemotaxis; cytosol; endomembrane system; guanyl-nucleotide exchange factor activity; membrane; small GTPase mediated signal transduction; stereocilium IPR027007; IPR027357; IPR026791; IPR026800; IPR010703; IPR011511; IPR001452; Dedicator of cytokinesis protein 4 DOCK4 KIAA0716 Homo sapiens (Human) TR41020_c4_g2_i2 Q8CIQ7 DOCK3_MOUSE 2.00E-32 GO:0005737; GO:0005085; GO:0007264 cytoplasm; guanyl-nucleotide exchange factor activity; small GTPase mediated signal transduction IPR016024; IPR027007; IPR027357; IPR026791; IPR026800; IPR010703; IPR011511; IPR001452; Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP) Dock3 Moca Mus musculus (Mouse) TR41020_c4_g6_i1 Q8CIQ7 DOCK3_MOUSE 8.00E-34 GO:0005737; GO:0005085; GO:0007264 cytoplasm; guanyl-nucleotide exchange factor activity; small GTPase mediated signal transduction IPR016024; IPR027007; IPR027357; IPR026791; IPR026800; IPR010703; IPR011511; IPR001452; Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP) Dock3 Moca Mus musculus (Mouse) TR41021_c7_g1_i1 Q9D2L9 F111A_MOUSE 3.00E-06 GO:0003824; GO:0005737; GO:0008152; GO:0045071; GO:0005634 catalytic activity; cytoplasm; metabolic process; negative regulation of viral genome replication; nucleus IPR009003; Protein FAM111A Fam111a Kiaa1895 Mus musculus (Mouse) TR41023_c0_g1_i1 Q38931 FKB62_ARATH 6.00E-65 GO:0070370; GO:0005737; GO:0005634; GO:0003755; GO:0006457; GO:0000413 D6RUV9; Q9FJL3; P27323 cellular heat acclimation; cytoplasm; nucleus; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR023566; IPR001179; IPR013026; IPR011990; IPR001440; IPR019734; Peptidyl-prolyl cis-trans isomerase FKBP62 (PPIase FKBP62) (EC 5.2.1.8) (70 kDa peptidyl-prolyl isomerase) (FK506-binding protein 62) (AtFKBP62) (Immunophilin FKBP62) (Peptidylprolyl isomerase ROF1) (Protein ROTAMASE FKBP 1) (Rotamase) FKBP62 ROF1 At3g25230 MJL12.19 Arabidopsis thaliana (Mouse-ear cress) TR41023_c0_g1_i2 Q02790 FKBP4_HUMAN 2.00E-140 GO:0005524; GO:0005528; GO:0005525; GO:0030521; GO:0044295; GO:0061077; GO:0006825; GO:0005829; GO:0007566; GO:0046661; GO:0016020; GO:0005874; GO:0005739; GO:0031115; GO:0031111; GO:0010977; GO:0043025; GO:0005634; GO:0003755; GO:0048471; GO:0030850; GO:0030674; GO:0031503; GO:0006463 P07900; P35467; P29034; P06703 "ATP binding; FK506 binding; GTP binding; androgen receptor signaling pathway; axonal growth cone; chaperone-mediated protein folding; copper ion transport; cytosol; embryo implantation; male sex differentiation; membrane; microtubule; mitochondrion; negative regulation of microtubule polymerization; negative regulation of microtubule polymerization or depolymerization; negative regulation of neuron projection development; neuronal cell body; nucleus; peptidyl-prolyl cis-trans isomerase activity; perinuclear region of cytoplasm; prostate gland development; protein binding, bridging; protein complex localization; steroid hormone receptor complex assembly" IPR023566; IPR001179; IPR013026; IPR011990; IPR001440; IPR019734; "Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]" FKBP4 FKBP52 Homo sapiens (Human) TR41023_c0_g1_i3 Q9Z247 FKBP9_MOUSE 4.00E-20 GO:0005528; GO:0005509; GO:0005783; GO:0005788; GO:0016020; GO:0003755; GO:0006457 FK506 binding; calcium ion binding; endoplasmic reticulum; endoplasmic reticulum lumen; membrane; peptidyl-prolyl cis-trans isomerase activity; protein folding IPR011992; IPR018247; IPR002048; IPR023566; IPR001179; Peptidyl-prolyl cis-trans isomerase FKBP9 (PPIase FKBP9) (EC 5.2.1.8) (63 kDa FK506-binding protein) (63 kDa FKBP) (FKBP-63) (FK506-binding protein 9) (FKBP-9) (FKBP65RS) (Rotamase) Fkbp9 Fkbp60 Fkbp63 Mus musculus (Mouse) TR41023_c0_g1_i4 Q9TRY0 FKBP4_BOVIN 2.00E-139 GO:0005528; GO:0044295; GO:0061077; GO:0005829; GO:0016020; GO:0005874; GO:0005739; GO:0031111; GO:0010977; GO:0005634; GO:0003755 FK506 binding; axonal growth cone; chaperone-mediated protein folding; cytosol; membrane; microtubule; mitochondrion; negative regulation of microtubule polymerization or depolymerization; negative regulation of neuron projection development; nucleus; peptidyl-prolyl cis-trans isomerase activity IPR023566; IPR001179; IPR013026; IPR011990; IPR001440; IPR019734; "Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (FK506-binding protein 4) (FKBP-4) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]" FKBP4 Bos taurus (Bovine) TR41023_c0_g1_i5 P27124 FKBP4_RABIT 7.00E-63 GO:0005524; GO:0005525; GO:0030521; GO:0044295; GO:0061077; GO:0005829; GO:0007566; GO:0046661; GO:0005874; GO:0005739; GO:0031111; GO:0010977; GO:0005634; GO:0003755; GO:0030850; GO:0031503; GO:0006463 ATP binding; GTP binding; androgen receptor signaling pathway; axonal growth cone; chaperone-mediated protein folding; cytosol; embryo implantation; male sex differentiation; microtubule; mitochondrion; negative regulation of microtubule polymerization or depolymerization; negative regulation of neuron projection development; nucleus; peptidyl-prolyl cis-trans isomerase activity; prostate gland development; protein complex localization; steroid hormone receptor complex assembly IPR023566; IPR001179; IPR013026; IPR011990; IPR001440; IPR019734; "Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]" FKBP4 P59 Oryctolagus cuniculus (Rabbit) TR41024_c1_g1_i2 Q56R14 TRI33_XENLA 3.00E-08 GO:0003677; GO:0016874; GO:0005634; GO:0016567; GO:0006355; GO:0006351; GO:0008270 "DNA binding; ligase activity; nucleus; protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 ecto Xenopus laevis (African clawed frog) TR41024_c1_g1_i3 Q13263 TIF1B_HUMAN 2.00E-10 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR41024_c3_g1_i1 Q0W874 DNAK_UNCMA 9.00E-07 GO:0005524; GO:0006457 ATP binding; protein folding IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK UNCMA_27580 LRC471 Uncultured methanogenic archaeon RC-I TR41024_c3_g1_i2 O43301 HS12A_HUMAN 2.00E-74 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR41024_c3_g1_i4 A8EWT6 DNAK_ARCB4 1.00E-06 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK Abu_2195 Arcobacter butzleri (strain RM4018) TR41024_c3_g1_i6 P20163 HSP7D_CAEEL 3.00E-10 GO:0005524; GO:0009790; GO:0034663; GO:0005788; GO:0030968 ATP binding; embryo development; endoplasmic reticulum chaperone complex; endoplasmic reticulum lumen; endoplasmic reticulum unfolded protein response IPR018181; IPR013126; Heat shock 70 kDa protein D hsp-4 hsp70d F43E2.8 Caenorhabditis elegans TR41025_c2_g1_i1 Q80U59 K0232_MOUSE 4.00E-12 GO:0005524 ATP binding IPR027871; Uncharacterized protein KIAA0232 Kiaa0232 D5Ertd579e Mus musculus (Mouse) TR41025_c6_g1_i1 Q6JAN0 GPR98_DANRE 2.00E-16 GO:0004930; GO:0042462; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; eye photoreceptor cell development; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR003644; IPR008985; IPR013320; IPR009039; IPR017981; IPR000832; IPR026919; IPR000203; IPR001791; IPR003609; G-protein coupled receptor 98 (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) gpr98 mass1 vlgr1 Danio rerio (Zebrafish) (Brachydanio rerio) TR41025_c6_g1_i2 Q5H8B9 FREM3_MOUSE 2.00E-11 GO:0005604; GO:0007155; GO:0007154; GO:0016021; GO:0046872 basement membrane; cell adhesion; cell communication; integral to membrane; metal ion binding IPR003644; FRAS1-related extracellular matrix protein 3 (NV domain-containing protein 2) Frem3 Gm795 Nv2 Mus musculus (Mouse) TR41025_c6_g1_i3 P57103 NAC3_HUMAN 0 GO:0007596; GO:0060402; GO:0005432; GO:0007154; GO:0071320; GO:0043197; GO:0016021; GO:0006811; GO:0005874; GO:0005739; GO:0043025; GO:0005886; GO:0042383; GO:0021537; GO:0055085 blood coagulation; calcium ion transport into cytosol; calcium:sodium antiporter activity; cell communication; cellular response to cAMP; dendritic spine; integral to membrane; ion transport; microtubule; mitochondrion; neuronal cell body; plasma membrane; sarcolemma; telencephalon development; transmembrane transport IPR003644; IPR004836; IPR004837; Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) SLC8A3 NCX3 Homo sapiens (Human) TR41025_c6_g1_i4 Q8WXG9 GPR98_HUMAN 7.00E-14 GO:0004930; GO:0005509; GO:0009986; GO:0016337; GO:0005737; GO:0050910; GO:0060122; GO:0016021; GO:0048496; GO:0007399; GO:0007218; GO:0045494; GO:0005886; GO:0050953; GO:0007605; GO:0002142; GO:0007601 G-protein coupled receptor activity; calcium ion binding; cell surface; cell-cell adhesion; cytoplasm; detection of mechanical stimulus involved in sensory perception of sound; inner ear receptor stereocilium organization; integral to membrane; maintenance of organ identity; nervous system development; neuropeptide signaling pathway; photoreceptor cell maintenance; plasma membrane; sensory perception of light stimulus; sensory perception of sound; stereocilia ankle link complex; visual perception IPR003644; IPR008985; IPR013320; IPR009039; IPR005492; IPR017981; IPR000832; IPR026919; IPR000203; G-protein coupled receptor 98 (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Usher syndrome type-2C protein) (Very large G-protein coupled receptor 1) GPR98 KIAA0686 KIAA1943 MASS1 VLGR1 Homo sapiens (Human) TR41025_c6_g1_i5 P70549 NAC3_RAT 0 GO:1990034; GO:1990035; GO:0060402; GO:0005432; GO:0007154; GO:0071320; GO:0043197; GO:0016021; GO:0005874; GO:0005739; GO:0043025; GO:0042383; GO:0021537 calcium ion export from cell; calcium ion import into cell; calcium ion transport into cytosol; calcium:sodium antiporter activity; cell communication; cellular response to cAMP; dendritic spine; integral to membrane; microtubule; mitochondrion; neuronal cell body; sarcolemma; telencephalon development IPR003644; IPR004836; IPR004837; Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) Slc8a3 Ncx3 Rattus norvegicus (Rat) TR41026_c3_g1_i1 P16395 ACM1_DROME 3.00E-08 GO:0016907; GO:0030054; GO:0005887; GO:0007200; GO:0045211 G-protein coupled acetylcholine receptor activity; cell junction; integral to plasma membrane; phospholipase C-activating G-protein coupled receptor signaling pathway; postsynaptic membrane IPR000276; IPR017452; IPR000995; Muscarinic acetylcholine receptor DM1 mAcR-60C AcrC CG4356 Drosophila melanogaster (Fruit fly) TR41027_c1_g2_i1 Q8R059 GALE_MOUSE 9.00E-146 GO:0003978; GO:0044237; GO:0050662; GO:0019388; GO:0006012 UDP-glucose 4-epimerase activity; cellular metabolic process; coenzyme binding; galactose catabolic process; galactose metabolic process IPR025308; IPR001509; IPR005886; IPR016040; IPR008089; Carbohydrate metabolism; galactose metabolism. UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-galactose 4-epimerase) Gale Mus musculus (Mouse) TR41027_c1_g2_i2 Q8R059 GALE_MOUSE 1.00E-146 GO:0003978; GO:0044237; GO:0050662; GO:0019388; GO:0006012 UDP-glucose 4-epimerase activity; cellular metabolic process; coenzyme binding; galactose catabolic process; galactose metabolic process IPR025308; IPR001509; IPR005886; IPR016040; IPR008089; Carbohydrate metabolism; galactose metabolism. UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-galactose 4-epimerase) Gale Mus musculus (Mouse) TR41027_c1_g2_i4 P33119 GALE_CORDI 2.00E-53 GO:0003978; GO:0044237; GO:0050662; GO:0006012 UDP-glucose 4-epimerase activity; cellular metabolic process; coenzyme binding; galactose metabolic process IPR025308; IPR001509; IPR005886; IPR016040; Carbohydrate metabolism; galactose metabolism. UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-galactose 4-epimerase) galE DIP1415 Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) TR41027_c1_g2_i5 Q9SN58 GALE2_ARATH 2.00E-125 GO:0003978; GO:0044237; GO:0050662; GO:0006012 UDP-glucose 4-epimerase activity; cellular metabolic process; coenzyme binding; galactose metabolic process IPR025308; IPR001509; IPR005886; IPR016040; IPR008089; Carbohydrate metabolism; galactose metabolism. UDP-glucose 4-epimerase 5 (AtUGE5) (EC 5.1.3.2) (UDP-galactose 4-epimerase 5) UGE5 At4g10960 F25I24.170 F8M12.10 Arabidopsis thaliana (Mouse-ear cress) TR41027_c1_g2_i6 P56600 GAL10_CANMA 1.00E-31 GO:0003978; GO:0004034; GO:0044237; GO:0050662; GO:0006012 UDP-glucose 4-epimerase activity; aldose 1-epimerase activity; cellular metabolic process; coenzyme binding; galactose metabolic process IPR001509; IPR005886; IPR016040; Carbohydrate metabolism; galactose metabolism. Carbohydrate metabolism; hexose metabolism. Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase); Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase)] (Fragment) GAL10 Candida maltosa (Yeast) TR41027_c1_g2_i7 Q8R059 GALE_MOUSE 1.00E-146 GO:0003978; GO:0044237; GO:0050662; GO:0019388; GO:0006012 UDP-glucose 4-epimerase activity; cellular metabolic process; coenzyme binding; galactose catabolic process; galactose metabolic process IPR025308; IPR001509; IPR005886; IPR016040; IPR008089; Carbohydrate metabolism; galactose metabolism. UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-galactose 4-epimerase) Gale Mus musculus (Mouse) TR41029_c0_g1_i1 Q58487 KIME_METJA 5.00E-19 GO:0005524; GO:0005737; GO:0008299; GO:0000287; GO:0004496 ATP binding; cytoplasm; isoprenoid biosynthetic process; magnesium ion binding; mevalonate kinase activity IPR013750; IPR006204; IPR006203; IPR006205; IPR006206; IPR022937; IPR020568; IPR014721; Mevalonate kinase (MK) (EC 2.7.1.36) mvk MJ1087 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR41029_c0_g1_i4 Q03426 KIME_HUMAN 2.00E-85 GO:0005524; GO:0006695; GO:0005829; GO:0019287; GO:0008299; GO:0004496; GO:0050728 Itself "ATP binding; cholesterol biosynthetic process; cytosol; isopentenyl diphosphate biosynthetic process, mevalonate pathway; isoprenoid biosynthetic process; mevalonate kinase activity; negative regulation of inflammatory response" IPR013750; IPR006204; IPR006203; IPR006205; IPR006206; IPR020568; IPR014721; Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3. Mevalonate kinase (MK) (EC 2.7.1.36) MVK Homo sapiens (Human) TR41029_c0_g2_i1 O34899 PDUO_BACSU 7.00E-22 GO:0005524; GO:0008817; GO:0009236; GO:0005737; GO:0006779 "ATP binding; cob(I)yrinic acid a,c-diamide adenosyltransferase activity; cobalamin biosynthetic process; cytoplasm; porphyrin-containing compound biosynthetic process" IPR016030; "Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7." "Cob(I)yrinic acid a,c-diamide adenosyltransferase (EC 2.5.1.17) (Cob(I)alamin adenosyltransferase)" yvqK BSU33150 Bacillus subtilis (strain 168) TR41029_c0_g2_i2 Q9D273 MMAB_MOUSE 3.00E-45 GO:0005524; GO:0008817; GO:0009236; GO:0005739 "ATP binding; cob(I)yrinic acid a,c-diamide adenosyltransferase activity; cobalamin biosynthetic process; mitochondrion" IPR016030; "Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7." "Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial (EC 2.5.1.17) (Cob(I)alamin adenosyltransferase) (Methylmalonic aciduria type B homolog)" Mmab Mus musculus (Mouse) TR41030_c0_g2_i1 Q9Y385 UB2J1_HUMAN 2.00E-20 GO:0005524; GO:0030433; GO:0005789; GO:0016021; GO:0018279; GO:0004842 ATP binding; ER-associated protein catabolic process; endoplasmic reticulum membrane; integral to membrane; protein N-linked glycosylation via asparagine; ubiquitin-protein ligase activity IPR000608; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 J1 (EC 6.3.2.19) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e) UBE2J1 NCUBE1 CGI-76 HSPC153 HSPC205 Homo sapiens (Human) TR41030_c0_g2_i4 Q9Y385 UB2J1_HUMAN 1.00E-81 GO:0005524; GO:0030433; GO:0005789; GO:0016021; GO:0018279; GO:0004842 ATP binding; ER-associated protein catabolic process; endoplasmic reticulum membrane; integral to membrane; protein N-linked glycosylation via asparagine; ubiquitin-protein ligase activity IPR000608; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 J1 (EC 6.3.2.19) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e) UBE2J1 NCUBE1 CGI-76 HSPC153 HSPC205 Homo sapiens (Human) TR41031_c2_g1_i2 Q9NXS3 KLH28_HUMAN 8.00E-06 IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR015916; IPR017096; IPR006652; Kelch-like protein 28 (BTB/POZ domain-containing protein 5) KLHL28 BTBD5 Homo sapiens (Human) TR41032_c2_g1_i1 Q99JX3 GORS2_MOUSE 2.00E-118 GO:0000139; GO:0006996 Golgi membrane; organelle organization IPR024958; IPR007583; IPR001478; Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) Gorasp2 Mus musculus (Mouse) TR41032_c2_g1_i2 Q91X51 GORS1_MOUSE 2.00E-91 GO:0005794; GO:0007030; GO:0016020; GO:0050774; GO:0015031 Golgi apparatus; Golgi organization; membrane; negative regulation of dendrite morphogenesis; protein transport IPR024958; IPR007583; IPR001478; Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) Gorasp1 Mus musculus (Mouse) TR41032_c2_g1_i3 Q9BQQ3 GORS1_HUMAN 5.00E-98 GO:0000139; GO:0007030; GO:0000278; GO:0050774; GO:0015031 Golgi membrane; Golgi organization; mitotic cell cycle; negative regulation of dendrite morphogenesis; protein transport IPR024958; IPR007583; IPR001478; Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) GORASP1 GOLPH5 GRASP65 Homo sapiens (Human) TR41033_c0_g1_i1 P97295 NPY2R_MOUSE 4.00E-06 GO:0016021; GO:0001601; GO:0005886 integral to membrane; peptide YY receptor activity; plasma membrane IPR000276; IPR017452; IPR001358; IPR000611; Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor) (Y2 receptor) Npy2r Mus musculus (Mouse) TR41033_c0_g1_i4 Q9Z2D5 NPY2R_CAVPO 3.00E-06 GO:0016021; GO:0004983; GO:0005886 integral to membrane; neuropeptide Y receptor activity; plasma membrane IPR000276; IPR017452; IPR001358; IPR000611; Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor) (Y2 receptor) NPY2R Cavia porcellus (Guinea pig) TR41033_c0_g1_i6 P56719 OX2R_RAT 3.00E-06 GO:0022410; GO:0007631; GO:0016021; GO:0007218; GO:0016499; GO:0017046; GO:0007200; GO:0005886 circadian sleep/wake cycle process; feeding behavior; integral to membrane; neuropeptide signaling pathway; orexin receptor activity; peptide hormone binding; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane IPR000276; IPR017452; IPR000204; IPR004060; Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Rattus norvegicus (Rat) TR41034_c1_g2_i1 Q8TCT0 CERK1_HUMAN 4.00E-40 GO:0005524; GO:0003951; GO:0001729; GO:0006672; GO:0005737; GO:0004143; GO:0006687; GO:0016021; GO:0000287; GO:0005739; GO:0005634; GO:0005543; GO:0005886; GO:0007205; GO:0044281 ATP binding; NAD+ kinase activity; ceramide kinase activity; ceramide metabolic process; cytoplasm; diacylglycerol kinase activity; glycosphingolipid metabolic process; integral to membrane; magnesium ion binding; mitochondrion; nucleus; phospholipid binding; plasma membrane; protein kinase C-activating G-protein coupled receptor signaling pathway; small molecule metabolic process IPR016064; IPR001206; IPR001849; Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) TR41034_c1_g2_i10 Q12246 LCB4_YEAST 1.00E-12 GO:0005524; GO:0017050; GO:0005794; GO:0000139; GO:0003951; GO:0019722; GO:0032541; GO:0004143; GO:0005789; GO:0031902; GO:0005886; GO:0007205; GO:0008481; GO:0006665 ATP binding; D-erythro-sphingosine kinase activity; Golgi apparatus; Golgi membrane; NAD+ kinase activity; calcium-mediated signaling; cortical endoplasmic reticulum; diacylglycerol kinase activity; endoplasmic reticulum membrane; late endosome membrane; plasma membrane; protein kinase C-activating G-protein coupled receptor signaling pathway; sphinganine kinase activity; sphingolipid metabolic process IPR016064; IPR001206; Sphingoid long chain base kinase 4 (LCB kinase 4) (EC 2.7.1.91) (Sphinganine kinase 4) LCB4 YOR171C O3615 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41034_c1_g2_i11 Q8K4Q7 CERK1_MOUSE 1.00E-39 GO:0005524; GO:0003951; GO:0001729; GO:0006672; GO:0004143; GO:0016021; GO:0000287; GO:0005739; GO:0005634; GO:0007205 ATP binding; NAD+ kinase activity; ceramide kinase activity; ceramide metabolic process; diacylglycerol kinase activity; integral to membrane; magnesium ion binding; mitochondrion; nucleus; protein kinase C-activating G-protein coupled receptor signaling pathway IPR016064; IPR001206; Ceramide kinase (mCERK) (EC 2.7.1.138) (Acylsphingosine kinase) Cerk Mus musculus (Mouse) TR41034_c1_g2_i12 Q86KF9 SPHKA_DICDI 2.00E-06 GO:0005524; GO:0017050; GO:0003951; GO:0005829; GO:0006648; GO:0005634; GO:0008284; GO:0007205; GO:0031143; GO:0008481; GO:0006665 ATP binding; D-erythro-sphingosine kinase activity; NAD+ kinase activity; cytosol; dihydrosphingosine-1-P pathway; nucleus; positive regulation of cell proliferation; protein kinase C-activating G-protein coupled receptor signaling pathway; pseudopodium; sphinganine kinase activity; sphingolipid metabolic process IPR016064; IPR001206; Sphingosine kinase A (SK A) (SPK A) (EC 2.7.1.91) sgkA SK SPHK DDB_G0272522 Dictyostelium discoideum (Slime mold) TR41034_c1_g2_i4 Q9LRB0 LCBK1_ARATH 4.00E-20 GO:0005524; GO:0017050; GO:0003951; GO:0004143; GO:0007205; GO:0030148 ATP binding; D-erythro-sphingosine kinase activity; NAD+ kinase activity; diacylglycerol kinase activity; protein kinase C-activating G-protein coupled receptor signaling pathway; sphingolipid biosynthetic process IPR016064; IPR001206; Sphingoid long-chain bases kinase 1 (AtLCBK1) (LCB kinase 1) (EC 2.7.-.-) (Sphingosine kinase 1) LCBK1 At5g23450 K19M13.8 Arabidopsis thaliana (Mouse-ear cress) TR41034_c1_g2_i8 O14159 LCB4_SCHPO 3.00E-14 GO:0005524; GO:0017050; GO:0000139; GO:0003951; GO:0019722; GO:0004143; GO:0005789; GO:0031902; GO:0005886; GO:0007205; GO:0046520 ATP binding; D-erythro-sphingosine kinase activity; Golgi membrane; NAD+ kinase activity; calcium-mediated signaling; diacylglycerol kinase activity; endoplasmic reticulum membrane; late endosome membrane; plasma membrane; protein kinase C-activating G-protein coupled receptor signaling pathway; sphingoid biosynthetic process IPR016064; IPR001206; Sphingoid long chain base kinase 4 (LCB kinase 4) (EC 2.7.1.-) lcb4 SPAC4A8.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41034_c1_g2_i9 Q8TCT0 CERK1_HUMAN 2.00E-41 GO:0005524; GO:0003951; GO:0001729; GO:0006672; GO:0005737; GO:0004143; GO:0006687; GO:0016021; GO:0000287; GO:0005739; GO:0005634; GO:0005543; GO:0005886; GO:0007205; GO:0044281 ATP binding; NAD+ kinase activity; ceramide kinase activity; ceramide metabolic process; cytoplasm; diacylglycerol kinase activity; glycosphingolipid metabolic process; integral to membrane; magnesium ion binding; mitochondrion; nucleus; phospholipid binding; plasma membrane; protein kinase C-activating G-protein coupled receptor signaling pathway; small molecule metabolic process IPR016064; IPR001206; IPR001849; Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) TR41035_c0_g2_i1 Q63416 ITIH3_RAT 3.00E-109 GO:0005576; GO:0030212; GO:0004867 extracellular region; hyaluronan metabolic process; serine-type endopeptidase inhibitor activity IPR010600; IPR013694; IPR002035; Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) Itih3 Rattus norvegicus (Rat) TR41035_c0_g2_i3 Q14624 ITIH4_HUMAN 2.00E-115 GO:0006953; GO:0005737; GO:0004866; GO:0005576; GO:0030212; GO:0005886; GO:0034097; GO:0004867 acute-phase response; cytoplasm; endopeptidase inhibitor activity; extracellular region; hyaluronan metabolic process; plasma membrane; response to cytokine stimulus; serine-type endopeptidase inhibitor activity IPR010600; IPR013694; IPR002035; Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (Gp120) (PK-120) [Cleaved into: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4] ITIH4 IHRP ITIHL1 PK120 PRO1851 Homo sapiens (Human) TR41035_c0_g2_i4 Q14624 ITIH4_HUMAN 2.00E-104 GO:0006953; GO:0005737; GO:0004866; GO:0005576; GO:0030212; GO:0005886; GO:0034097; GO:0004867 acute-phase response; cytoplasm; endopeptidase inhibitor activity; extracellular region; hyaluronan metabolic process; plasma membrane; response to cytokine stimulus; serine-type endopeptidase inhibitor activity IPR010600; IPR013694; IPR002035; Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (Gp120) (PK-120) [Cleaved into: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4] ITIH4 IHRP ITIHL1 PK120 PRO1851 Homo sapiens (Human) TR41036_c1_g1_i3 Q98925 IRF2_CHICK 6.00E-35 GO:0005925; GO:0005634; GO:0000975; GO:0003700; GO:0006351 "focal adhesion; nucleus; regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017431; IPR019817; IPR001346; IPR011991; Interferon regulatory factor 2 (IRF-2) IRF2 Gallus gallus (Chicken) TR41036_c1_g1_i5 Q8R4E0 IRF2_SIGHI 3.00E-36 GO:0005634; GO:0000975; GO:0003700; GO:0006351 "nucleus; regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017431; IPR019817; IPR001346; IPR011991; Interferon regulatory factor 2 (IRF-2) IRF2 Sigmodon hispidus (Hispid cotton rat) TR41037_c0_g1_i5 P14562 LAMP1_RAT 4.00E-06 GO:0097208; GO:0048102; GO:0006914; GO:0030425; GO:0010008; GO:0009897; GO:0016021; GO:0005765; GO:0042470; GO:0005771; GO:0043025; GO:0042383; GO:0005773 alveolar lamellar body; autophagic cell death; autophagy; dendrite; endosome membrane; external side of plasma membrane; integral to membrane; lysosomal membrane; melanosome; multivesicular body; neuronal cell body; sarcolemma; vacuole IPR018134; IPR002000; Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (120 kDa lysosomal membrane glycoprotein) (LGP-120) (CD107 antigen-like family member A) (CD antigen CD107a) Lamp1 Lamp-1 Rattus norvegicus (Rat) TR41038_c3_g3_i1 Q9UKJ5 CHIC2_HUMAN 5.00E-63 GO:0005798; GO:0005886 Q9H8W4 Golgi-associated vesicle; plasma membrane IPR019383; Cysteine-rich hydrophobic domain 2 protein (BrX-like translocated in leukemia) CHIC2 BTL Homo sapiens (Human) TR41038_c3_g5_i2 A6NMZ7 CO6A6_HUMAN 1.00E-54 GO:0007155; GO:0005581; GO:0030574; GO:0031012; GO:0022617; GO:0005576 cell adhesion; collagen; collagen catabolic process; extracellular matrix; extracellular matrix disassembly; extracellular region IPR008160; IPR002035; Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) TR41038_c3_g5_i3 A6QLN9 VWA1_BOVIN 9.00E-13 GO:0005604; GO:0048266; GO:0030198; GO:0005614; GO:0005840; GO:0003735; GO:0006412 basement membrane; behavioral response to pain; extracellular matrix organization; interstitial matrix; ribosome; structural constituent of ribosome; translation IPR003961; IPR013783; IPR020592; IPR002035; von Willebrand factor A domain-containing protein 1 Bos taurus (Bovine) TR41038_c3_g7_i1 Q9UKJ5 CHIC2_HUMAN 1.00E-59 GO:0005798; GO:0005886 Q9H8W4 Golgi-associated vesicle; plasma membrane IPR019383; Cysteine-rich hydrophobic domain 2 protein (BrX-like translocated in leukemia) CHIC2 BTL Homo sapiens (Human) TR41039_c0_g2_i2 Q5R4G6 CUL1_PONAB 0 GO:0019005; GO:0031146; GO:0016567 SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination IPR016157; IPR016158; IPR001373; IPR019559; IPR016159; IPR011991; Protein modification; protein ubiquitination. Cullin-1 (CUL-1) CUL1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41040_c0_g2_i4 Q5R4X4 SSRA_PONAB 4.00E-49 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR005595; Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) SSR1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41040_c0_g2_i5 Q54R45 SSRA_DICDI 1.00E-18 GO:0005789; GO:0016021; GO:0045335 endoplasmic reticulum membrane; integral to membrane; phagocytic vesicle IPR005595; Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) ssr1 DDB_G0283497 Dictyostelium discoideum (Slime mold) TR41040_c0_g2_i6 Q5R4X4 SSRA_PONAB 5.00E-49 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR005595; Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) SSR1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41040_c0_g2_i7 Q54R45 SSRA_DICDI 4.00E-19 GO:0005789; GO:0016021; GO:0045335 endoplasmic reticulum membrane; integral to membrane; phagocytic vesicle IPR005595; Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) ssr1 DDB_G0283497 Dictyostelium discoideum (Slime mold) TR41041_c0_g3_i1 O43264 ZW10_HUMAN 3.00E-134 GO:0006888; GO:0051301; GO:0019237; GO:0000777; GO:0005829; GO:0005783; GO:0005789; GO:0000132; GO:0000776; GO:0005828; GO:0007126; GO:0007093; GO:0007080; GO:0005634; GO:0006461; GO:0034501; GO:0015031; GO:0007096; GO:0000922 O95229 ER to Golgi vesicle-mediated transport; cell division; centromeric DNA binding; condensed chromosome kinetochore; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; establishment of mitotic spindle orientation; kinetochore; kinetochore microtubule; meiosis; mitotic cell cycle checkpoint; mitotic metaphase plate congression; nucleus; protein complex assembly; protein localization to kinetochore; protein transport; regulation of exit from mitosis; spindle pole IPR009361; Centromere/kinetochore protein zw10 homolog ZW10 Homo sapiens (Human) TR41041_c0_g3_i2 O44219 ZW10_DROGR 5.00E-34 GO:0051301; GO:0000777; GO:0005737; GO:0007126; GO:0007067; GO:0005634 cell division; condensed chromosome kinetochore; cytoplasm; meiosis; mitosis; nucleus IPR009361; Centromere/kinetochore protein zw10 (Mitotic 15 protein) mit(1)15 ZW10 Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) TR41042_c0_g1_i1 Q91WC0 SETD3_MOUSE 4.00E-135 GO:0046975; GO:0042800; GO:0000790; GO:0018027; GO:0018026; GO:0018023; GO:0051149; GO:0045944; GO:0003713; GO:0006351 "histone methyltransferase activity (H3-K36 specific); histone methyltransferase activity (H3-K4 specific); nuclear chromatin; peptidyl-lysine dimethylation; peptidyl-lysine monomethylation; peptidyl-lysine trimethylation; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcription, DNA-dependent" IPR025785; IPR015353; IPR001214; Histone-lysine N-methyltransferase setd3 (EC 2.1.1.43) (Endothelial differentiation inhibitory protein D10) (SET domain-containing protein 3) Setd3 D12Ertd771e Mus musculus (Mouse) TR41042_c0_g1_i2 Q9XI84 RBCMT_ARATH 6.00E-21 GO:0030785; GO:0009570; GO:0018023; GO:0016279 [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity; chloroplast stroma; peptidyl-lysine trimethylation; protein-lysine N-methyltransferase activity IPR015353; IPR011192; IPR001214; "[Fructose-bisphosphate aldolase]-lysine N-methyltransferase, chloroplastic (EC 2.1.1.259) (Aldolases N-methyltransferase) ([Ribulose-bisphosphate carboxylase]-lysine N-methyltransferase-like) (AtLSMT-L) (LSMT-like enzyme)" LSMT-L RBCMT At1g14030 F16A14.25 F7A19.12 Arabidopsis thaliana (Mouse-ear cress) TR41042_c0_g3_i2 B7ZUF3 SETD3_XENTR 2.00E-12 GO:0046975; GO:0005634; GO:0018027; GO:0018026; GO:0018023; GO:0045893; GO:0003713; GO:0006351 "histone methyltransferase activity (H3-K36 specific); nucleus; peptidyl-lysine dimethylation; peptidyl-lysine monomethylation; peptidyl-lysine trimethylation; positive regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent" IPR025785; IPR015353; IPR001214; Histone-lysine N-methyltransferase setd3 (EC 2.1.1.43) (SET domain-containing protein 3) setd3 TEgg034h09.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41043_c0_g1_i1 Q8IZ69 TRM2A_HUMAN 2.00E-170 GO:0003723; GO:0001510; GO:0008173; GO:0006396; GO:0000166 RNA binding; RNA methylation; RNA methyltransferase activity; RNA processing; nucleotide binding IPR012677; IPR000504; IPR010280; tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.-) (HpaII tiny fragments locus 9c protein) TRMT2A HTF9C Homo sapiens (Human) TR41043_c0_g1_i2 Q96GJ1 TRM2_HUMAN 5.00E-102 GO:0030697; GO:0005739 S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity; mitochondrion IPR025714; IPR025823; tRNA (uracil(54)-C(5))-methyltransferase homolog (EC 2.1.1.35) (TRM2 homolog) TRMT2B CXorf34 Homo sapiens (Human) TR41043_c0_g1_i6 Q8IZ69 TRM2A_HUMAN 8.00E-56 GO:0003723; GO:0001510; GO:0008173; GO:0006396; GO:0000166 RNA binding; RNA methylation; RNA methyltransferase activity; RNA processing; nucleotide binding IPR012677; IPR000504; IPR010280; tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.-) (HpaII tiny fragments locus 9c protein) TRMT2A HTF9C Homo sapiens (Human) TR41045_c1_g1_i1 P19477 FIBA_PARPA 5.00E-39 IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein A (FREP-A) Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) TR41045_c1_g1_i2 Q8R0Z6 ANGL6_MOUSE 2.00E-36 GO:0001525; GO:0030154; GO:0005576; GO:0030141 angiogenesis; cell differentiation; extracellular region; secretory granule IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-related protein 6 (Angiopoietin-like protein 6) (Angiopoietin-related growth factor) Angptl6 Agf Mus musculus (Mouse) TR41045_c1_g1_i5 O77802 ANGP2_BOVIN 2.00E-31 GO:0048014; GO:0001525; GO:0030154; GO:0005615; GO:0046872; GO:0016525; GO:0043537; GO:0010812; GO:0050928 Tie signaling pathway; angiogenesis; cell differentiation; extracellular space; metal ion binding; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of cell-substrate adhesion; negative regulation of positive chemotaxis IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-2 (ANG-2) ANGPT2 ANG2 Bos taurus (Bovine) TR41045_c1_g1_i6 Q5XK91 FBCDB_XENLA 2.00E-41 GO:0008061; GO:0016021; GO:0046872 chitin binding; integral to membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1-B fibcd1-b Xenopus laevis (African clawed frog) TR41045_c1_g1_i7 P19477 FIBA_PARPA 6.00E-40 IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein A (FREP-A) Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) TR41047_c0_g1_i1 Q69YN4 VIR_HUMAN 1.00E-74 GO:0008380; GO:0006397; GO:0005634 RNA splicing; mRNA processing; nucleus IPR016024; IPR026736; Protein virilizer homolog KIAA1429 MSTP054 Homo sapiens (Human) TR41048_c0_g1_i1 O60231 DHX16_HUMAN 0 GO:0005524; GO:0008026; GO:0003724; GO:0008380; GO:0006397; GO:0003676; GO:0005634 Q92620; Q92917; Q13435; Q9HCS7 ATP binding; ATP-dependent helicase activity; RNA helicase activity; RNA splicing; mRNA processing; nucleic acid binding; nucleus IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16) DHX16 DBP2 DDX16 KIAA0577 Homo sapiens (Human) TR41048_c1_g1_i3 O35286 DHX15_MOUSE 0 GO:0005524; GO:0008026; GO:0008380; GO:0005689; GO:0003725; GO:0006397; GO:0005730 ATP binding; ATP-dependent helicase activity; RNA splicing; U12-type spliceosomal complex; double-stranded RNA binding; mRNA processing; nucleolus IPR003593; IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (DEAH box protein 15) Dhx15 Ddx15 Deah9 Mus musculus (Mouse) TR41048_c1_g1_i5 O35286 DHX15_MOUSE 0 GO:0005524; GO:0008026; GO:0008380; GO:0005689; GO:0003725; GO:0006397; GO:0005730 ATP binding; ATP-dependent helicase activity; RNA splicing; U12-type spliceosomal complex; double-stranded RNA binding; mRNA processing; nucleolus IPR003593; IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (DEAH box protein 15) Dhx15 Ddx15 Deah9 Mus musculus (Mouse) TR41048_c1_g1_i6 Q8VHK9 DHX36_MOUSE 3.00E-43 GO:0005524; GO:0008026; GO:0003725; GO:0005634; GO:0043330; GO:0009615 ATP binding; ATP-dependent helicase activity; double-stranded RNA binding; nucleus; response to exogenous dsRNA; response to virus IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Probable ATP-dependent RNA helicase DHX36 (EC 3.6.4.13) (DEAH box protein 36) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE) Dhx36 Ddx36 Kiaa1488 Mlel1 Mus musculus (Mouse) TR41049_c0_g1_i1 Q710D3 UN93A_MOUSE 1.00E-69 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR010291; IPR016196; Protein unc-93 homolog A (Unc-93A) Unc93a Mus musculus (Mouse) TR41049_c0_g1_i3 Q6PB15 MFS11_XENLA 2.00E-06 GO:0016021 integral to membrane IPR010291; IPR016196; UNC93-like protein MFSD11 (Major facilitator superfamily domain-containing protein 11) mfsd11 Xenopus laevis (African clawed frog) TR41049_c0_g1_i4 Q6DDL7 UN93A_XENLA 4.00E-23 GO:0016021 integral to membrane IPR010291; IPR016196; Protein unc-93 homolog A (Unc-93A) unc93a Xenopus laevis (African clawed frog) TR41050_c1_g2_i1 P10073 ZSC22_HUMAN 2.00E-35 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 22 (Krueppel-related zinc finger protein 2) (Protein HKR2) (Zinc finger protein 50) ZSCAN22 HKR2 ZNF50 Homo sapiens (Human) TR41050_c1_g3_i1 P0C6P6 TYY2_RAT 1.00E-15 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR017114; IPR007087; IPR015880; IPR013087; Transcription factor YY2 (Yin and yang 2) (YY-2) Yy2 Rattus norvegicus (Rat) TR41050_c1_g3_i2 P20385 CF2_DROME 2.00E-26 GO:0001077; GO:0007527; GO:0046872; GO:0005634; GO:0032968; GO:0043565 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; adult somatic muscle development; metal ion binding; nucleus; positive regulation of transcription elongation from RNA polymerase II promoter; sequence-specific DNA binding IPR007087; IPR015880; IPR013087; Chorion transcription factor Cf2 Cf2 CG11924 Drosophila melanogaster (Fruit fly) TR41050_c1_g3_i3 Q01872 KRUP_LITFO 5.00E-12 GO:0003677; GO:0046872; GO:0005634; GO:0035282 DNA binding; metal ion binding; nucleus; segmentation IPR007087; IPR015880; IPR013087; Protein krueppel (Fragment) Kr Lithobius forficatus TR41053_c1_g1_i1 C3YWU0 FUCO_BRAFL 8.00E-162 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR41053_c1_g1_i2 C3YWU0 FUCO_BRAFL 0 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR41053_c1_g1_i7 P49713 FUCO_CAEEL 1.00E-137 GO:0004560; GO:0042806; GO:0006004; GO:0005764 alpha-L-fucosidase activity; fucose binding; fucose metabolic process; lysosome IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Putative alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) W03G11.3 Caenorhabditis elegans TR41055_c1_g1_i1 Q5VT06 CE350_HUMAN 4.00E-19 GO:0005813; GO:0005737; GO:0005634; GO:0005819 centrosome; cytoplasm; nucleus; spindle IPR000938; Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) CEP350 CAP350 KIAA0480 GM133 Homo sapiens (Human) TR41055_c2_g1_i1 B9EHT4 CLIP3_MOUSE 8.00E-19 GO:0005795; GO:0072321; GO:0031901; GO:0045444; GO:0035594; GO:0044091; GO:0045121; GO:0008017; GO:0031115; GO:0018230; GO:0005886; GO:0043065; GO:0045807; GO:0090004; GO:0010828; GO:0001934; GO:0055038; GO:0032588 Golgi stack; chaperone-mediated protein transport; early endosome membrane; fat cell differentiation; ganglioside binding; membrane biogenesis; membrane raft; microtubule binding; negative regulation of microtubule polymerization; peptidyl-L-cysteine S-palmitoylation; plasma membrane; positive regulation of apoptotic process; positive regulation of endocytosis; positive regulation of establishment of protein localization to plasma membrane; positive regulation of glucose transport; positive regulation of protein phosphorylation; recycling endosome membrane; trans-Golgi network membrane IPR002110; IPR020683; IPR000938; CAP-Gly domain-containing linker protein 3 (Cytoplasmic linker protein 170-related 59 kDa protein) (CLIP-170-related 59 kDa protein) (CLIPR-59) Clip3 Clipr59 Mus musculus (Mouse) TR41055_c2_g1_i10 B9EHT4 CLIP3_MOUSE 2.00E-20 GO:0005795; GO:0072321; GO:0031901; GO:0045444; GO:0035594; GO:0044091; GO:0045121; GO:0008017; GO:0031115; GO:0018230; GO:0005886; GO:0043065; GO:0045807; GO:0090004; GO:0010828; GO:0001934; GO:0055038; GO:0032588 Golgi stack; chaperone-mediated protein transport; early endosome membrane; fat cell differentiation; ganglioside binding; membrane biogenesis; membrane raft; microtubule binding; negative regulation of microtubule polymerization; peptidyl-L-cysteine S-palmitoylation; plasma membrane; positive regulation of apoptotic process; positive regulation of endocytosis; positive regulation of establishment of protein localization to plasma membrane; positive regulation of glucose transport; positive regulation of protein phosphorylation; recycling endosome membrane; trans-Golgi network membrane IPR002110; IPR020683; IPR000938; CAP-Gly domain-containing linker protein 3 (Cytoplasmic linker protein 170-related 59 kDa protein) (CLIP-170-related 59 kDa protein) (CLIPR-59) Clip3 Clipr59 Mus musculus (Mouse) TR41055_c2_g1_i2 Q9VJE5 CL190_DROME 2.00E-30 GO:0005794; GO:0003779; GO:0007349; GO:0045169; GO:0000776; GO:0005875; GO:0051010; GO:0007017; GO:0005876 Golgi apparatus; actin binding; cellularization; fusome; kinetochore; microtubule associated complex; microtubule plus-end binding; microtubule-based process; spindle microtubule IPR000938; Restin homolog (Cytoplasmic linker protein 190) (Microtubule-binding protein 190) (d-CLIP-190) CLIP-190 CG5020 Drosophila melanogaster (Fruit fly) TR41055_c2_g1_i3 Q9VJE5 CL190_DROME 3.00E-23 GO:0005794; GO:0003779; GO:0007349; GO:0045169; GO:0000776; GO:0005875; GO:0051010; GO:0007017; GO:0005876 Golgi apparatus; actin binding; cellularization; fusome; kinetochore; microtubule associated complex; microtubule plus-end binding; microtubule-based process; spindle microtubule IPR000938; Restin homolog (Cytoplasmic linker protein 190) (Microtubule-binding protein 190) (d-CLIP-190) CLIP-190 CG5020 Drosophila melanogaster (Fruit fly) TR41055_c2_g1_i4 O42184 CLIP1_CHICK 4.00E-19 GO:0005813; GO:0005881; GO:0030659; GO:0044354; GO:0001578; GO:0003676; GO:0031116; GO:0001726; GO:0006810; GO:0008270 centrosome; cytoplasmic microtubule; cytoplasmic vesicle membrane; macropinosome; microtubule bundle formation; nucleic acid binding; positive regulation of microtubule polymerization; ruffle; transport; zinc ion binding IPR000938; IPR001878; CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 170) (CLIP-170) (Restin) CLIP1 RSN Gallus gallus (Chicken) TR41055_c2_g1_i9 Q8CI96 CLIP4_MOUSE 4.00E-22 IPR002110; IPR020683; IPR000938; CAP-Gly domain-containing linker protein 4 (Restin-like protein 2) Clip4 Rsnl2 Mus musculus (Mouse) TR41062_c4_g2_i10 Q3ZKN1 CATK_CANFA 2.00E-76 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR015644; IPR013201; Cathepsin K (EC 3.4.22.38) CTSK Canis familiaris (Dog) (Canis lupus familiaris) TR41062_c4_g2_i11 P12400 CTL2B_MOUSE 2.00E-08 GO:0004869; GO:0008234 cysteine-type endopeptidase inhibitor activity; cysteine-type peptidase activity IPR013128; IPR013201; Protein CTLA-2-beta (Cytotoxic T-lymphocyte-associated protein 2-beta) Ctla2b Mus musculus (Mouse) TR41062_c4_g2_i4 P25773 CATL1_FELCA 5.00E-36 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR025660; IPR013128; IPR000668; Cathepsin L1 (EC 3.4.22.15) (Cathepsin L) (Progesterone-dependent protein) (PDP) (Fragment) CTSL CTSL1 Felis catus (Cat) (Felis silvestris catus) TR41062_c4_g2_i9 Q26636 CATL_SARPE 6.00E-79 GO:0030154; GO:0008234; GO:0005764; GO:0007275; GO:0006508 cell differentiation; cysteine-type peptidase activity; lysosome; multicellular organismal development; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) TR41062_c4_g4_i1 Q26636 CATL_SARPE 1.00E-35 GO:0030154; GO:0008234; GO:0005764; GO:0007275; GO:0006508 cell differentiation; cysteine-type peptidase activity; lysosome; multicellular organismal development; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) TR41062_c4_g8_i1 P04989 CYSP2_DICDI 2.00E-10 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cysteine proteinase 2 (EC 3.4.22.-) (Prestalk cathepsin) cprB CP2 DDB_G0279799 Dictyostelium discoideum (Slime mold) TR41064_c1_g2_i1 Q6DHR3 RG1BA_DANRE 7.00E-174 GO:0005088; GO:0005622; GO:0051056; GO:0007264 Ras guanyl-nucleotide exchange factor activity; intracellular; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR000651; IPR019804; IPR008937; IPR023578; IPR001895; Ras-GEF domain-containing family member 1B-A rasgef1ba rasgef1b si:dkey-18e17.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR41064_c1_g2_i3 Q552M5 GEFY_DICDI 1.00E-18 GO:0005085; GO:0005622; GO:0051056; GO:0007264 guanyl-nucleotide exchange factor activity; intracellular; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR000651; IPR008937; IPR023578; IPR001895; Ras guanine nucleotide exchange factor Y (RasGEF domain-containing protein Y) gefY rasGEFY DDB_G0276019 Dictyostelium discoideum (Slime mold) TR41064_c1_g2_i4 A6N9I4 GRP2_BOVIN 5.00E-11 GO:0005509; GO:0030054; GO:0005829; GO:0005085; GO:0043005; GO:0051056; GO:0032587; GO:0007264; GO:0045202 calcium ion binding; cell junction; cytosol; guanyl-nucleotide exchange factor activity; neuron projection; regulation of small GTPase mediated signal transduction; ruffle membrane; small GTPase mediated signal transduction; synapse IPR011992; IPR018247; IPR002048; IPR002219; IPR000651; IPR008937; IPR023578; IPR001895; RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) RASGRP2 Bos taurus (Bovine) TR41064_c1_g2_i5 Q6DHR3 RG1BA_DANRE 7.00E-177 GO:0005088; GO:0005622; GO:0051056; GO:0007264 Ras guanyl-nucleotide exchange factor activity; intracellular; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR000651; IPR019804; IPR008937; IPR023578; IPR001895; Ras-GEF domain-containing family member 1B-A rasgef1ba rasgef1b si:dkey-18e17.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR41064_c1_g2_i6 Q6DHR3 RG1BA_DANRE 6.00E-172 GO:0005088; GO:0005622; GO:0051056; GO:0007264 Ras guanyl-nucleotide exchange factor activity; intracellular; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR000651; IPR019804; IPR008937; IPR023578; IPR001895; Ras-GEF domain-containing family member 1B-A rasgef1ba rasgef1b si:dkey-18e17.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR41065_c0_g2_i1 Q9VM75 HEAT1_DROME 1.00E-51 GO:0022008; GO:0005730; GO:0006364; GO:0030529 neurogenesis; nucleolus; rRNA processing; ribonucleoprotein complex IPR011989; IPR016024; IPR012954; IPR022125; HEAT repeat-containing protein 1 homolog l(2)k09022 CG10805 Drosophila melanogaster (Fruit fly) TR41065_c0_g2_i3 Q9GM44 HEAT1_MACFA 8.00E-90 GO:0005730; GO:0006364; GO:0030529 nucleolus; rRNA processing; ribonucleoprotein complex IPR011989; IPR016024; IPR012954; HEAT repeat-containing protein 1 (Protein BAP28) (Fragment) HEATR1 BAP28 QnpA-17571 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR41066_c0_g1_i1 Q5GLH2 TRIB2_BOVIN 1.00E-104 GO:0005737; GO:0005856; GO:0045599; GO:0045081; GO:0006469; GO:0005634; GO:0032436; GO:0004860; GO:0043405; GO:0016772; GO:0055106 "cytoplasm; cytoskeleton; negative regulation of fat cell differentiation; negative regulation of interleukin-10 biosynthetic process; negative regulation of protein kinase activity; nucleus; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein kinase inhibitor activity; regulation of MAP kinase activity; transferase activity, transferring phosphorus-containing groups; ubiquitin-protein ligase regulator activity" IPR011009; IPR000719; IPR024104; Tribbles homolog 2 (TRB-2) TRIB2 Bos taurus (Bovine) TR41066_c0_g1_i3 Q6ZLP5 CIPKN_ORYSJ 7.00E-32 GO:0005524; GO:0004674; GO:0007165 ATP binding; protein serine/threonine kinase activity; signal transduction IPR020636; IPR011009; IPR018451; IPR004041; IPR000719; IPR017441; IPR002290; IPR008271; CBL-interacting protein kinase 23 (EC 2.7.11.1) (OsCIPK23) CIPK23 Os07g0150700 LOC_Os07g05620 OJ1027_G06.32 Oryza sativa subsp. japonica (Rice) TR41066_c0_g1_i4 Q5GLH2 TRIB2_BOVIN 1.00E-104 GO:0005737; GO:0005856; GO:0045599; GO:0045081; GO:0006469; GO:0005634; GO:0032436; GO:0004860; GO:0043405; GO:0016772; GO:0055106 "cytoplasm; cytoskeleton; negative regulation of fat cell differentiation; negative regulation of interleukin-10 biosynthetic process; negative regulation of protein kinase activity; nucleus; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein kinase inhibitor activity; regulation of MAP kinase activity; transferase activity, transferring phosphorus-containing groups; ubiquitin-protein ligase regulator activity" IPR011009; IPR000719; IPR024104; Tribbles homolog 2 (TRB-2) TRIB2 Bos taurus (Bovine) TR41067_c0_g1_i2 Q2KID0 EXOS2_BOVIN 2.00E-138 GO:0003723; GO:0005737; GO:0000178; GO:0005730; GO:0030307; GO:0006364 RNA binding; cytoplasm; exosome (RNase complex); nucleolus; positive regulation of cell growth; rRNA processing IPR025721; IPR026699; IPR012340; IPR022967; Exosome complex component RRP4 (Exosome component 2) (Ribosomal RNA-processing protein 4) EXOSC2 RRP4 Bos taurus (Bovine) TR41068_c0_g1_i1 Q7ZUZ0 CSN8_DANRE 3.00E-33 GO:0008180; GO:0005737 COP9 signalosome; cytoplasm COP9 signalosome complex subunit 8 (Signalosome subunit 8) cops8 zgc:56319 Danio rerio (Zebrafish) (Brachydanio rerio) TR41068_c0_g5_i2 Q7ZUZ0 CSN8_DANRE 5.00E-56 GO:0008180; GO:0005737 COP9 signalosome; cytoplasm COP9 signalosome complex subunit 8 (Signalosome subunit 8) cops8 zgc:56319 Danio rerio (Zebrafish) (Brachydanio rerio) TR41069_c0_g2_i2 Q8R4F0 MCLN3_MOUSE 2.00E-129 GO:0042491; GO:0005737; GO:0016021; GO:0006811; GO:0007626; GO:0005886 auditory receptor cell differentiation; cytoplasm; integral to membrane; ion transport; locomotory behavior; plasma membrane IPR013122; Mucolipin-3 Mcoln3 Mus musculus (Mouse) TR41069_c0_g2_i4 Q8R4F0 MCLN3_MOUSE 1.00E-57 GO:0042491; GO:0005737; GO:0016021; GO:0006811; GO:0007626; GO:0005886 auditory receptor cell differentiation; cytoplasm; integral to membrane; ion transport; locomotory behavior; plasma membrane IPR013122; Mucolipin-3 Mcoln3 Mus musculus (Mouse) TR41070_c0_g1_i1 Q68F72 S15A4_XENLA 4.00E-48 GO:0016021; GO:0006857; GO:0015031; GO:0015293 integral to membrane; oligopeptide transport; protein transport; symporter activity IPR016196; IPR000109; IPR018456; Solute carrier family 15 member 4 (Peptide transporter 4) slc15a4 Xenopus laevis (African clawed frog) TR41070_c0_g1_i2 Q9M172 PTR42_ARATH 2.00E-11 GO:0016021; GO:0042128; GO:0006857; GO:0005215 integral to membrane; nitrate assimilation; oligopeptide transport; transporter activity IPR016196; IPR000109; IPR018456; Probable nitrate excretion transporter 6 (Protein NAXT1-like 5) At3g45710 T6D9.40 Arabidopsis thaliana (Mouse-ear cress) TR41070_c0_g1_i3 Q8LPL2 PTR32_ARATH 7.00E-12 GO:0016021; GO:0005886; GO:0005215 integral to membrane; plasma membrane; transporter activity IPR016196; IPR000109; Probable peptide/nitrate transporter At3g16180 At3g16180 MSL1.22 Arabidopsis thaliana (Mouse-ear cress) TR41070_c0_g1_i8 Q944G5 PTR44_ARATH 1.00E-23 GO:0016021; GO:0005215 integral to membrane; transporter activity IPR016196; IPR000109; Probable peptide/nitrate transporter At3g47960 At3g47960 T17F15.170 Arabidopsis thaliana (Mouse-ear cress) TR41070_c0_g1_i9 Q68F72 S15A4_XENLA 4.00E-44 GO:0016021; GO:0006857; GO:0015031; GO:0015293 integral to membrane; oligopeptide transport; protein transport; symporter activity IPR016196; IPR000109; IPR018456; Solute carrier family 15 member 4 (Peptide transporter 4) slc15a4 Xenopus laevis (African clawed frog) TR41070_c0_g2_i2 A6NIM6 S15A5_HUMAN 7.00E-31 GO:0016021; GO:0015833; GO:0015031; GO:0015293 integral to membrane; peptide transport; protein transport; symporter activity IPR016196; IPR000109; Solute carrier family 15 member 5 SLC15A5 Homo sapiens (Human) TR41070_c0_g2_i3 Q9FM20 PTR54_ARATH 8.00E-21 GO:0016021; GO:0005215 integral to membrane; transporter activity IPR016196; IPR000109; Probable peptide/nitrate transporter At5g62730 At5g62730 MQB2.30 Arabidopsis thaliana (Mouse-ear cress) TR41071_c0_g1_i1 A0MZ66 SHOT1_HUMAN 5.00E-07 GO:0030424; GO:0007411 axon; axon guidance IPR024849; Shootin-1 KIAA1598 Homo sapiens (Human) TR41072_c0_g2_i2 P05450 YAT7_RHOBL 6.00E-09 GO:0030246; GO:0007155 carbohydrate binding; cell adhesion IPR019019; ATP synthase subunits region ORF 7 Rhodopseudomonas blastica TR41072_c1_g1_i1 Q5ZI22 NUPL2_CHICK 2.00E-07 GO:0051028; GO:0046872; GO:0031965; GO:0005643; GO:0015031 mRNA transport; metal ion binding; nuclear membrane; nuclear pore; protein transport IPR000571; Nucleoporin-like protein 2 NUPL2 RCJMB04_31e20 Gallus gallus (Chicken) TR41072_c1_g1_i12 Q8CIC2 NUPL2_MOUSE 3.00E-10 GO:0051028; GO:0046872; GO:0031965; GO:0005643; GO:0015031 mRNA transport; metal ion binding; nuclear membrane; nuclear pore; protein transport IPR000571; Nucleoporin-like protein 2 (NLP-1) Nupl2 Mus musculus (Mouse) TR41072_c1_g1_i3 Q8CIC2 NUPL2_MOUSE 1.00E-10 GO:0051028; GO:0046872; GO:0031965; GO:0005643; GO:0015031 mRNA transport; metal ion binding; nuclear membrane; nuclear pore; protein transport IPR000571; Nucleoporin-like protein 2 (NLP-1) Nupl2 Mus musculus (Mouse) TR41073_c2_g2_i2 P48637 GSHB_HUMAN 3.00E-65 GO:0005524; GO:0007568; GO:0005829; GO:0043295; GO:1901687; GO:0004363; GO:0016594; GO:0000287; GO:0007399; GO:0042803; GO:0043200; GO:0046686; GO:0031667; GO:0006979; GO:0034612; GO:0006805 ATP binding; aging; cytosol; glutathione binding; glutathione derivative biosynthetic process; glutathione synthase activity; glycine binding; magnesium ion binding; nervous system development; protein homodimerization activity; response to amino acid stimulus; response to cadmium ion; response to nutrient levels; response to oxidative stress; response to tumor necrosis factor; xenobiotic metabolic process IPR004887; IPR014042; IPR014709; IPR005615; IPR014049; IPR016185; Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase) GSS Homo sapiens (Human) TR41073_c2_g2_i3 Q08220 GSHB_YEAST 2.00E-18 GO:0005524; GO:0043295; GO:0004363; GO:0005622; GO:0000287; GO:0042803 Itself; P10592 ATP binding; glutathione binding; glutathione synthase activity; intracellular; magnesium ion binding; protein homodimerization activity IPR004887; IPR014042; IPR014709; IPR005615; IPR014049; IPR016185; Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase) GSH2 YOL049W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41074_c0_g2_i1 Q5IS62 NPY2R_PANTR 2.00E-06 GO:0003214; GO:0016021; GO:0003151; GO:0001601; GO:0005886 cardiac left ventricle morphogenesis; integral to membrane; outflow tract morphogenesis; peptide YY receptor activity; plasma membrane IPR000276; IPR017452; IPR001358; IPR000611; Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor) (Y2 receptor) NPY2R Pan troglodytes (Chimpanzee) TR41074_c0_g2_i2 Q56H79 NPSR1_MACMU 4.00E-09 GO:0016021; GO:0008188; GO:0005886; GO:0005000 integral to membrane; neuropeptide receptor activity; plasma membrane; vasopressin receptor activity IPR000276; IPR017452; IPR027294; IPR001817; Neuropeptide S receptor (G-protein coupled receptor 154) NPSR1 GPR154 Macaca mulatta (Rhesus macaque) TR41075_c0_g1_i1 Q8TAQ2 SMRC2_HUMAN 0 GO:0003677; GO:0016514; GO:0003682; GO:0006338; GO:0071565; GO:0045892; GO:0007399; GO:0071564; GO:0006337; GO:0045893; GO:0006357; GO:0003713; GO:0006351 "DNA binding; SWI/SNF complex; chromatin binding; chromatin remodeling; nBAF complex; negative regulation of transcription, DNA-dependent; nervous system development; npBAF complex; nucleosome disassembly; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcription, DNA-dependent" IPR001357; IPR000953; IPR009057; IPR001005; IPR017884; IPR007526; IPR011991; SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) SMARCC2 BAF170 Homo sapiens (Human) TR41075_c0_g1_i2 Q96P47 AGAP3_HUMAN 2.00E-103 GO:0008060; GO:0005525; GO:0003924; GO:0071944; GO:0034614; GO:0005737; GO:0016020; GO:0005634; GO:0005543; GO:0043547; GO:0043161; GO:0000060; GO:0032312; GO:0007264; GO:0008270 "ARF GTPase activator activity; GTP binding; GTPase activity; cell periphery; cellular response to reactive oxygen species; cytoplasm; membrane; nucleus; phospholipid binding; positive regulation of GTPase activity; proteasomal ubiquitin-dependent protein catabolic process; protein import into nucleus, translocation; regulation of ARF GTPase activity; small GTPase mediated signal transduction; zinc ion binding" IPR002110; IPR020683; IPR001164; IPR013684; IPR027417; IPR011993; IPR001849; IPR020849; "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP-3) (CRAM-associated GTPase) (CRAG) (Centaurin-gamma-3) (Cnt-g3) (MR1-interacting protein) (MRIP-1)" AGAP3 CENTG3 Homo sapiens (Human) TR41075_c0_g1_i3 Q92922 SMRC1_HUMAN 5.00E-168 GO:0003677; GO:0016514; GO:0071778; GO:0001741; GO:0003682; GO:0006338; GO:0008286; GO:0071565; GO:0007399; GO:0071564; GO:0006337; GO:0009887; GO:0045944; GO:0045893; GO:0006357; GO:0003713; GO:0006351 P51532; Q96GM5 "DNA binding; SWI/SNF complex; WINAC complex; XY body; chromatin binding; chromatin remodeling; insulin receptor signaling pathway; nBAF complex; nervous system development; npBAF complex; nucleosome disassembly; organ morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcription, DNA-dependent" IPR001357; IPR000953; IPR009057; IPR001005; IPR017884; IPR007526; IPR011991; SWI/SNF complex subunit SMARCC1 (BRG1-associated factor 155) (BAF155) (SWI/SNF complex 155 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1) SMARCC1 BAF155 Homo sapiens (Human) TR41077_c2_g1_i1 P48614 WN10B_MOUSE 2.00E-41 GO:0000086; GO:0060346; GO:0060070; GO:0007050; GO:0045165; GO:0007267; GO:0071320; GO:0071374; GO:0002062; GO:0005615; GO:0005109; GO:0061196; GO:0071425; GO:0006629; GO:0014835; GO:0050680; GO:0045599; GO:0000122; GO:0030182; GO:0010971; GO:0045899; GO:0051885; GO:0043065; GO:0030501; GO:0090263; GO:0008284; GO:0030858; GO:0045669; GO:0051091; GO:0050821; GO:0005578; GO:0032434; GO:0048641; GO:0050909; GO:0048741; GO:0007224 G2/M transition of mitotic cell cycle; bone trabecula formation; canonical Wnt receptor signaling pathway; cell cycle arrest; cell fate commitment; cell-cell signaling; cellular response to cAMP; cellular response to parathyroid hormone stimulus; chondrocyte differentiation; extracellular space; frizzled binding; fungiform papilla development; hematopoietic stem cell proliferation; lipid metabolic process; myoblast differentiation involved in skeletal muscle regeneration; negative regulation of epithelial cell proliferation; negative regulation of fat cell differentiation; negative regulation of transcription from RNA polymerase II promoter; neuron differentiation; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; positive regulation of anagen; positive regulation of apoptotic process; positive regulation of bone mineralization; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell proliferation; positive regulation of epithelial cell differentiation; positive regulation of osteoblast differentiation; positive regulation of sequence-specific DNA binding transcription factor activity; protein stabilization; proteinaceous extracellular matrix; regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of skeletal muscle tissue development; sensory perception of taste; skeletal muscle fiber development; smoothened signaling pathway IPR005817; IPR013302; IPR018161; Protein Wnt-10b (Protein Wnt-12) Wnt10b Wnt-10b Wnt10 Wnt12 Mus musculus (Mouse) TR41077_c2_g1_i2 B2GUT4 WNT11_XENTR 9.00E-82 GO:0005099; GO:0005737; GO:0033337; GO:0005576; GO:0007369; GO:0003007; GO:0043066; GO:0090090; GO:0030308; GO:0030336; GO:0045892; GO:0001755; GO:0061101; GO:0035567; GO:0060021; GO:0046330; GO:0030335; GO:0090037; GO:0051496; GO:0045893; GO:0048793; GO:0030295; GO:0034394; GO:0006468; GO:0005578; GO:0010470; GO:0044212 "Ras GTPase activator activity; cytoplasm; dorsal fin development; extracellular region; gastrulation; heart morphogenesis; negative regulation of apoptotic process; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of cell growth; negative regulation of cell migration; negative regulation of transcription, DNA-dependent; neural crest cell migration; neuroendocrine cell differentiation; non-canonical Wnt receptor signaling pathway; palate development; positive regulation of JNK cascade; positive regulation of cell migration; positive regulation of protein kinase C signaling cascade; positive regulation of stress fiber assembly; positive regulation of transcription, DNA-dependent; pronephros development; protein kinase activator activity; protein localization to cell surface; protein phosphorylation; proteinaceous extracellular matrix; regulation of gastrulation; transcription regulatory region DNA binding" IPR005817; IPR026536; IPR018161; Protein Wnt-11 (Protein Wnt-11-related) wnt11 wnt11r Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41077_c2_g1_i3 B2GUT4 WNT11_XENTR 9.00E-82 GO:0005099; GO:0005737; GO:0033337; GO:0005576; GO:0007369; GO:0003007; GO:0043066; GO:0090090; GO:0030308; GO:0030336; GO:0045892; GO:0001755; GO:0061101; GO:0035567; GO:0060021; GO:0046330; GO:0030335; GO:0090037; GO:0051496; GO:0045893; GO:0048793; GO:0030295; GO:0034394; GO:0006468; GO:0005578; GO:0010470; GO:0044212 "Ras GTPase activator activity; cytoplasm; dorsal fin development; extracellular region; gastrulation; heart morphogenesis; negative regulation of apoptotic process; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of cell growth; negative regulation of cell migration; negative regulation of transcription, DNA-dependent; neural crest cell migration; neuroendocrine cell differentiation; non-canonical Wnt receptor signaling pathway; palate development; positive regulation of JNK cascade; positive regulation of cell migration; positive regulation of protein kinase C signaling cascade; positive regulation of stress fiber assembly; positive regulation of transcription, DNA-dependent; pronephros development; protein kinase activator activity; protein localization to cell surface; protein phosphorylation; proteinaceous extracellular matrix; regulation of gastrulation; transcription regulatory region DNA binding" IPR005817; IPR026536; IPR018161; Protein Wnt-11 (Protein Wnt-11-related) wnt11 wnt11r Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41077_c2_g1_i4 P09615 WNTG_DROME 5.00E-35 GO:0061332; GO:0061382; GO:0005112; GO:0060061; GO:0007223; GO:0051017; GO:0035288; GO:0008595; GO:0035147; GO:0010002; GO:0030054; GO:0009986; GO:0035017; GO:0035225; GO:0007394; GO:0007398; GO:0030139; GO:0005783; GO:0008544; GO:0061331; GO:0035153; GO:0050840; GO:0005615; GO:0046847; GO:0005110; GO:0035224; GO:0035263; GO:0005539; GO:0060914; GO:0007446; GO:0007476; GO:0002168; GO:0035217; GO:0030032; GO:0007523; GO:0007479; GO:0035170; GO:0045121; GO:0048332; GO:0016015; GO:0005771; GO:0032876; GO:0043066; GO:0003136; GO:0045611; GO:0045892; GO:0014019; GO:0030182; GO:0016318; GO:0030707; GO:0061320; GO:0005886; GO:0008284; GO:0046672; GO:0042691; GO:0061328; GO:0035289; GO:0048728; GO:0005578; GO:0048076; GO:0007346; GO:0072091; GO:0007367; GO:0035277; GO:0045202; GO:0035290; GO:0007419; GO:0007418; GO:0035311; GO:0048190 Q7KV06 "Malpighian tubule bud morphogenesis; Malpighian tubule tip cell differentiation; Notch binding; Spemann organizer formation; Wnt receptor signaling pathway, calcium modulating pathway; actin filament bundle assembly; anterior head segmentation; anterior/posterior axis specification, embryo; branch fusion, open tracheal system; cardioblast differentiation; cell junction; cell surface; cuticle pattern formation; determination of genital disc primordium; dorsal closure, elongation of leading edge cells; ectoderm development; endocytic vesicle; endoplasmic reticulum; epidermis development; epithelial cell proliferation involved in Malpighian tubule morphogenesis; epithelial cell type specification, open tracheal system; extracellular matrix binding; extracellular space; filopodium assembly; frizzled-2 binding; genital disc anterior/posterior pattern formation; genital disc sexually dimorphic development; glycosaminoglycan binding; heart formation; imaginal disc growth; imaginal disc-derived wing morphogenesis; instar larval development; labial disc development; lamellipodium assembly; larval visceral muscle development; leg disc proximal/distal pattern formation; lymph gland crystal cell differentiation; membrane raft; mesoderm morphogenesis; morphogen activity; multivesicular body; negative regulation of DNA endoreduplication; negative regulation of apoptotic process; negative regulation of heart induction by canonical Wnt receptor signaling pathway; negative regulation of hemocyte differentiation; negative regulation of transcription, DNA-dependent; neuroblast development; neuron differentiation; ommatidial rotation; ovarian follicle cell development; pericardial nephrocyte differentiation; plasma membrane; positive regulation of cell proliferation; positive regulation of compound eye retinal cell programmed cell death; positive regulation of crystal cell differentiation; posterior Malpighian tubule development; posterior head segmentation; proboscis development; proteinaceous extracellular matrix; regulation of compound eye pigmentation; regulation of mitotic cell cycle; regulation of stem cell proliferation; segment polarity determination; spiracle morphogenesis, open tracheal system; synapse; trunk segmentation; ventral cord development; ventral midline development; wing cell fate specification; wing disc dorsal/ventral pattern formation" IPR005817; IPR009139; IPR018161; Protein wingless (Protein Wnt-1) (Protein int-1) (dInt-1) (dWnt-1) wg CG4889 Drosophila melanogaster (Fruit fly) TR41080_c0_g1_i1 Q9BYK8 PR285_HUMAN 1.00E-12 GO:0005524; GO:0003677; GO:0044255; GO:0004386; GO:0030374; GO:0046872; GO:0005654; GO:0045944; GO:0044281; GO:0006351 "ATP binding; DNA binding; cellular lipid metabolic process; helicase activity; ligand-dependent nuclear receptor transcription coactivator activity; metal ion binding; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; small molecule metabolic process; transcription, DNA-dependent" IPR003593; IPR026122; IPR012340; IPR027417; IPR022966; IPR015880; "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) TR41080_c3_g3_i1 Q8IWR0 Z3H7A_HUMAN 9.00E-09 GO:0046872; GO:0005634 metal ion binding; nucleus IPR011990; IPR015880; IPR000571; Zinc finger CCCH domain-containing protein 7A ZC3H7A ZC3H7 ZC3HDC7 HSPC055 Homo sapiens (Human) TR41080_c5_g2_i2 Q9BYK8 PR285_HUMAN 3.00E-91 GO:0005524; GO:0003677; GO:0044255; GO:0004386; GO:0030374; GO:0046872; GO:0005654; GO:0045944; GO:0044281; GO:0006351 "ATP binding; DNA binding; cellular lipid metabolic process; helicase activity; ligand-dependent nuclear receptor transcription coactivator activity; metal ion binding; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; small molecule metabolic process; transcription, DNA-dependent" IPR003593; IPR026122; IPR012340; IPR027417; IPR022966; IPR015880; "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) TR41080_c6_g1_i1 Q6NYU2 HELZ_DANRE 2.00E-53 GO:0005524; GO:0004386; GO:0046872; GO:0005634; GO:0003700 ATP binding; helicase activity; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity IPR027417; IPR011539; IPR000571; Probable helicase with zinc finger domain (EC 3.6.4.-) helz zgc:77407 Danio rerio (Zebrafish) (Brachydanio rerio) TR41081_c4_g1_i5 Q640Z9 LRC14_XENLA 9.00E-10 IPR001611; IPR026292; Leucine-rich repeat-containing protein 14 lrrc14 Xenopus laevis (African clawed frog) TR41081_c4_g1_i6 Q640Z9 LRC14_XENLA 1.00E-09 IPR001611; IPR026292; Leucine-rich repeat-containing protein 14 lrrc14 Xenopus laevis (African clawed frog) TR41082_c5_g1_i1 O60229 KALRN_HUMAN 9.00E-103 GO:0005524; GO:0005089; GO:0015629; GO:0097190; GO:0005829; GO:0005085; GO:0046872; GO:0007399; GO:0048011; GO:0005543; GO:0043065; GO:0004674; GO:0035023; GO:0051056; GO:0007264; GO:0016192 ATP binding; Rho guanyl-nucleotide exchange factor activity; actin cytoskeleton; apoptotic signaling pathway; cytosol; guanyl-nucleotide exchange factor activity; metal ion binding; nervous system development; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of apoptotic process; protein serine/threonine kinase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; vesicle-mediated transport IPR001251; IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR017441; IPR002290; IPR008271; IPR001452; IPR018159; IPR002017; Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain) KALRN DUET DUO HAPIP TRAD Homo sapiens (Human) TR41082_c6_g1_i1 Q9CWR0 ARHGP_MOUSE 4.00E-73 GO:0005089; GO:0030016; GO:0005543; GO:0005886; GO:0035023; GO:0030017 Rho guanyl-nucleotide exchange factor activity; myofibril; phospholipid binding; plasma membrane; regulation of Rho protein signal transduction; sarcomere IPR000219; IPR011993; IPR001849; Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT) (p63RhoGEF) Arhgef25 D10Ertd610e Geft Mus musculus (Mouse) TR41082_c6_g1_i2 Q6P720 ARHGP_RAT 9.00E-59 GO:0005089; GO:0030016; GO:0005886; GO:0035023; GO:0030017 Rho guanyl-nucleotide exchange factor activity; myofibril; plasma membrane; regulation of Rho protein signal transduction; sarcomere IPR000219; IPR011993; Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT) Arhgef25 Geft Rattus norvegicus (Rat) TR41082_c6_g1_i3 Q58EX7 PKHG4_HUMAN 8.00E-23 GO:0005089; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; phospholipid binding; regulation of Rho protein signal transduction IPR001251; IPR000219; IPR011993; IPR001849; Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1) PLEKHG4 PRTPHN1 Homo sapiens (Human) TR41082_c6_g3_i1 Q1LUA6 TRIO_DANRE 7.00E-98 GO:0005524; GO:0005089; GO:0005737; GO:0005543; GO:0004674; GO:0035023 ATP binding; Rho guanyl-nucleotide exchange factor activity; cytoplasm; phospholipid binding; protein serine/threonine kinase activity; regulation of Rho protein signal transduction IPR001251; IPR000219; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR017441; IPR002290; IPR008271; IPR001452; IPR018159; IPR002017; Triple functional domain protein (EC 2.7.11.1) trio si:dkey-158b13.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR41082_c6_g3_i2 Q86VW2 ARHGP_HUMAN 8.00E-38 GO:0005089; GO:0005829; GO:0030016; GO:0005543; GO:0005886; GO:0035023; GO:0030017 Rho guanyl-nucleotide exchange factor activity; cytosol; myofibril; phospholipid binding; plasma membrane; regulation of Rho protein signal transduction; sarcomere IPR000219; IPR011993; IPR001849; Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT) (p63RhoGEF) ARHGEF25 GEFT Homo sapiens (Human) TR41083_c0_g2_i1 Q9VWP4 SUOX_DROME 2.00E-160 GO:0009055; GO:0020037; GO:0005758; GO:0030151; GO:0030163; GO:0008482; GO:0006790 electron carrier activity; heme binding; mitochondrial intermembrane space; molybdenum ion binding; protein catabolic process; sulfite oxidase activity; sulfur compound metabolic process IPR001199; IPR018506; IPR014756; IPR005066; IPR008335; IPR000572; Energy metabolism; sulfur metabolism. "Probable sulfite oxidase, mitochondrial (EC 1.8.3.1)" CG7280 Drosophila melanogaster (Fruit fly) TR41083_c0_g2_i2 P16081 NIA1_ORYSJ 4.00E-58 GO:0009055; GO:0050660; GO:0020037; GO:0005506; GO:0030151; GO:0043546; GO:0042128; GO:0009703 electron carrier activity; flavin adenine dinucleotide binding; heme binding; iron ion binding; molybdenum ion binding; molybdopterin cofactor binding; nitrate assimilation; nitrate reductase (NADH) activity IPR001199; IPR018506; IPR017927; IPR001709; IPR014756; IPR005066; IPR008335; IPR001834; IPR012137; IPR008333; IPR001433; IPR000572; IPR022407; IPR017938; Nitrate reductase [NADH] 1 (NR1) (EC 1.7.1.1) NIA1 Os08g0468100 LOC_Os08g36480 P0470B03.25 Oryza sativa subsp. japonica (Rice) TR41083_c0_g2_i3 P16081 NIA1_ORYSJ 2.00E-57 GO:0009055; GO:0050660; GO:0020037; GO:0005506; GO:0030151; GO:0043546; GO:0042128; GO:0009703 electron carrier activity; flavin adenine dinucleotide binding; heme binding; iron ion binding; molybdenum ion binding; molybdopterin cofactor binding; nitrate assimilation; nitrate reductase (NADH) activity IPR001199; IPR018506; IPR017927; IPR001709; IPR014756; IPR005066; IPR008335; IPR001834; IPR012137; IPR008333; IPR001433; IPR000572; IPR022407; IPR017938; Nitrate reductase [NADH] 1 (NR1) (EC 1.7.1.1) NIA1 Os08g0468100 LOC_Os08g36480 P0470B03.25 Oryza sativa subsp. japonica (Rice) TR41083_c0_g2_i4 Q9VWP4 SUOX_DROME 2.00E-164 GO:0009055; GO:0020037; GO:0005758; GO:0030151; GO:0030163; GO:0008482; GO:0006790 electron carrier activity; heme binding; mitochondrial intermembrane space; molybdenum ion binding; protein catabolic process; sulfite oxidase activity; sulfur compound metabolic process IPR001199; IPR018506; IPR014756; IPR005066; IPR008335; IPR000572; Energy metabolism; sulfur metabolism. "Probable sulfite oxidase, mitochondrial (EC 1.8.3.1)" CG7280 Drosophila melanogaster (Fruit fly) TR41084_c0_g2_i1 P54960 HMDH_BLAGE 4.00E-141 GO:0050661; GO:0015936; GO:0005789; GO:0004420; GO:0016021; GO:0008299 NADP binding; coenzyme A metabolic process; endoplasmic reticulum membrane; hydroxymethylglutaryl-CoA reductase (NADPH) activity; integral to membrane; isoprenoid biosynthetic process IPR002202; IPR023074; IPR023076; IPR004554; IPR004816; IPR023282; IPR009023; IPR009029; IPR000731; Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3. 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) Blattella germanica (German cockroach) (Blatta germanica) TR41084_c0_g3_i1 O51628 HMDH_BORBU 9.00E-07 GO:0015936; GO:0050662; GO:0004420; GO:0042282 coenzyme A metabolic process; coenzyme binding; hydroxymethylglutaryl-CoA reductase (NADPH) activity; hydroxymethylglutaryl-CoA reductase activity IPR002202; IPR004553; IPR023074; IPR009023; IPR009029; Metabolic intermediate metabolism; (R)-mevalonate degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate: step 1/1. Probable 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.88) BB_0685 Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) TR41084_c0_g3_i2 Q6GQT6 SCAP_MOUSE 4.00E-06 GO:0012507; GO:0000139; GO:0032933; GO:0007568; GO:0015485; GO:0008203; GO:0005789; GO:0016021; GO:0043234; GO:0045540; GO:0042304; GO:0001666; GO:0032868 ER to Golgi transport vesicle membrane; Golgi membrane; SREBP signaling pathway; aging; cholesterol binding; cholesterol metabolic process; endoplasmic reticulum membrane; integral to membrane; protein complex; regulation of cholesterol biosynthetic process; regulation of fatty acid biosynthetic process; response to hypoxia; response to insulin stimulus IPR000731; IPR015943; IPR001680; IPR019775; IPR017986; Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) Scap Kiaa0199 Mus musculus (Mouse) TR41085_c3_g1_i1 Q9WYG0 Y325_THEMA 1.00E-43 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Uncharacterized oxidoreductase TM_0325 (EC 1.-.-.-) TM_0325 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR41085_c3_g1_i10 Q2FVD5 Y2778_STAA8 1.00E-28 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; Uncharacterized oxidoreductase SAOUHSC_02778 (EC 1.-.-.-) SAOUHSC_02778 Staphylococcus aureus (strain NCTC 8325) TR41085_c3_g1_i13 Q9WYG0 Y325_THEMA 1.00E-38 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Uncharacterized oxidoreductase TM_0325 (EC 1.-.-.-) TM_0325 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR41085_c3_g1_i3 Q9P324 YI78_SCHPO 4.00E-11 GO:0005829; GO:0005634; GO:0016491 cytosol; nucleus; oxidoreductase activity IPR002198; IPR002347; IPR016040; Uncharacterized oxidoreductase C977.08/C1348.09 (EC 1.-.-.-) SPAC977.08; SPAC1348.09 SPBC1348.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41085_c3_g1_i5 B2X050 MNR1_CAPAN 3.00E-06 GO:0047501; GO:0006952 (+)-neomenthol dehydrogenase activity; defense response IPR002198; IPR002347; IPR016040; (+)-neomenthol dehydrogenase (EC 1.1.1.208) (Menthone:neomenthol reductase 1) (CaMNR1) MNR1 Capsicum annuum (Bell pepper) TR41085_c3_g1_i7 P73016 FABI_SYNY3 1.00E-12 GO:0004318; GO:0030497; GO:0051289 enoyl-[acyl-carrier-protein] reductase (NADH) activity; fatty acid elongation; protein homotetramerization IPR014358; IPR002347; IPR016040; Lipid metabolism; fatty acid biosynthesis. Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (ENR) (EC 1.3.1.9) (NADH-dependent enoyl-ACP reductase) fabI envM slr1051 Synechocystis sp. (strain PCC 6803 / Kazusa) TR41085_c3_g1_i9 Q9X248 FABG_THEMA 4.00E-40 GO:0004316; GO:0051287; GO:0050661; GO:0030497 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NAD binding; NADP binding; fatty acid elongation IPR011284; IPR002198; IPR002347; IPR016040; IPR020904; Lipid metabolism; fatty acid biosynthesis. 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) (Beta-Ketoacyl-acyl carrier protein reductase) (Beta-ketoacyl-ACP reductase) fabG TM_1724 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR41086_c1_g1_i1 Q27U48 TBB1_GLOMM 0 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR013838; IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta-1 chain (Beta-1-tubulin) Glossina morsitans morsitans (Savannah tsetse fly) TR41086_c1_g2_i2 P08841 TBB3_DROME 0 GO:0005525; GO:0003924; GO:0007411; GO:0005737; GO:0007507; GO:0030537; GO:0005874; GO:0007017; GO:0051258; GO:0009416; GO:0005200 GTP binding; GTPase activity; axon guidance; cytoplasm; heart development; larval behavior; microtubule; microtubule-based process; protein polymerization; response to light stimulus; structural constituent of cytoskeleton IPR013838; IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta-3 chain (Beta-3-tubulin) betaTub60D TubB60C CG3401 Drosophila melanogaster (Fruit fly) TR41086_c1_g2_i3 O17449 TBB1_MANSE 0 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR013838; IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta-1 chain (Beta-1-tubulin) Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) TR41086_c1_g2_i4 P86221 TBB4B_MESAU 1.00E-77 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR013838; IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta-4B chain (Tubulin beta-2C chain) (Fragments) TUBB4B TUBB2C Mesocricetus auratus (Golden hamster) TR41087_c1_g1_i2 Q03172 ZEP1_MOUSE 3.00E-06 GO:0003677; GO:0046872; GO:0000122; GO:0005634; GO:0006351 P63085 "DNA binding; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 40 (Alpha A-crystallin-binding protein 1) (Alpha A-CRYBP1) (Alpha A-crystallin-binding protein I) (Transcription factor alphaA-CRYBP1) Hivep1 Cryabp1 Znf40 Mus musculus (Mouse) TR41087_c1_g2_i1 A6NN14 ZN729_HUMAN 2.00E-17 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 729 ZNF729 Homo sapiens (Human) TR41088_c0_g1_i1 Q6DBY2 NAA50_DANRE 8.00E-84 GO:0008080; GO:0005737; GO:0007275 N-acetyltransferase activity; cytoplasm; multicellular organismal development IPR016181; IPR000182; N-alpha-acetyltransferase 50 (EC 2.3.1.-) (N-acetyltransferase NAT13) (NatE catalytic subunit) naa50 mak3 nat13 Danio rerio (Zebrafish) (Brachydanio rerio) TR41088_c0_g1_i11 Q9NHD5 SAN_DROME 3.00E-86 GO:0008080; GO:0008280; GO:0005737; GO:0046331; GO:0007064; GO:0048812; GO:0031248 N-acetyltransferase activity; cohesin core heterodimer; cytoplasm; lateral inhibition; mitotic sister chromatid cohesion; neuron projection morphogenesis; protein acetyltransferase complex IPR016181; IPR000182; Probable N-acetyltransferase san (EC 2.3.1.-) (Protein separation anxiety) san span CG12352 Drosophila melanogaster (Fruit fly) TR41088_c0_g1_i15 Q6DBY2 NAA50_DANRE 2.00E-84 GO:0008080; GO:0005737; GO:0007275 N-acetyltransferase activity; cytoplasm; multicellular organismal development IPR016181; IPR000182; N-alpha-acetyltransferase 50 (EC 2.3.1.-) (N-acetyltransferase NAT13) (NatE catalytic subunit) naa50 mak3 nat13 Danio rerio (Zebrafish) (Brachydanio rerio) TR41088_c0_g1_i8 Q9NHD5 SAN_DROME 4.00E-86 GO:0008080; GO:0008280; GO:0005737; GO:0046331; GO:0007064; GO:0048812; GO:0031248 N-acetyltransferase activity; cohesin core heterodimer; cytoplasm; lateral inhibition; mitotic sister chromatid cohesion; neuron projection morphogenesis; protein acetyltransferase complex IPR016181; IPR000182; Probable N-acetyltransferase san (EC 2.3.1.-) (Protein separation anxiety) san span CG12352 Drosophila melanogaster (Fruit fly) TR41088_c0_g1_i9 Q6DBY2 NAA50_DANRE 9.00E-84 GO:0008080; GO:0005737; GO:0007275 N-acetyltransferase activity; cytoplasm; multicellular organismal development IPR016181; IPR000182; N-alpha-acetyltransferase 50 (EC 2.3.1.-) (N-acetyltransferase NAT13) (NatE catalytic subunit) naa50 mak3 nat13 Danio rerio (Zebrafish) (Brachydanio rerio) TR41089_c3_g1_i1 O95470 SGPL1_HUMAN 0 GO:0033327; GO:0008209; GO:0016831; GO:0019752; GO:0006672; GO:0008210; GO:0097194; GO:0060325; GO:0010761; GO:0030097; GO:0030176; GO:0001822; GO:0001553; GO:0060021; GO:0048008; GO:0009791; GO:0030170; GO:0040014; GO:0048705; GO:0044281; GO:0007283; GO:0008117; GO:0030148; GO:0030149; GO:0001570 Q86WV6 Leydig cell differentiation; androgen metabolic process; carboxy-lyase activity; carboxylic acid metabolic process; ceramide metabolic process; estrogen metabolic process; execution phase of apoptosis; face morphogenesis; fibroblast migration; hemopoiesis; integral to endoplasmic reticulum membrane; kidney development; luteinization; palate development; platelet-derived growth factor receptor signaling pathway; post-embryonic development; pyridoxal phosphate binding; regulation of multicellular organism growth; skeletal system morphogenesis; small molecule metabolic process; spermatogenesis; sphinganine-1-phosphate aldolase activity; sphingolipid biosynthetic process; sphingolipid catabolic process; vasculogenesis IPR002129; IPR015424; IPR015421; Lipid metabolism; sphingolipid metabolism. Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase) SGPL1 KIAA1252 Homo sapiens (Human) TR41090_c0_g4_i1 Q9NXW2 DJB12_HUMAN 1.00E-84 GO:0016021 integral to membrane IPR001623; IPR018253; IPR015399; DnaJ homolog subfamily B member 12 DNAJB12 Homo sapiens (Human) TR41091_c2_g1_i1 P21329 RTJK_DROFU 2.00E-21 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) TR41091_c3_g1_i2 Q5FYB0 ARSJ_HUMAN 1.00E-110 GO:0004065; GO:0005788; GO:0005576; GO:0006687; GO:0046872; GO:0043687; GO:0044281 arylsulfatase activity; endoplasmic reticulum lumen; extracellular region; glycosphingolipid metabolic process; metal ion binding; post-translational protein modification; small molecule metabolic process IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase J (ASJ) (EC 3.1.6.-) ARSJ UNQ372/PRO708 Homo sapiens (Human) TR41093_c1_g2_i2 Q8MJC3 CASP3_RABIT 2.00E-31 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Oryctolagus cuniculus (Rabbit) TR41093_c1_g2_i4 Q08DY9 CASP3_BOVIN 4.00E-28 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Bos taurus (Bovine) TR41093_c1_g2_i7 O02002 CASP1_DROME 2.00E-24 GO:0007015; GO:0009267; GO:0006922; GO:0004197; GO:0007303; GO:0010623; GO:0009790; GO:1900074; GO:0016322; GO:0045476; GO:0016239; GO:0035071 "actin filament organization; cellular response to starvation; cleavage of lamin involved in execution phase of apoptosis; cysteine-type endopeptidase activity; cytoplasmic transport, nurse cell to oocyte; developmental programmed cell death; embryo development; negative regulation of neuromuscular synaptic transmission; neuron remodeling; nurse cell apoptotic process; positive regulation of macroautophagy; salivary gland cell autophagic cell death" IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-1 (EC 3.4.22.-) [Cleaved into: Caspase-1 subunit p22; Caspase-1 subunit p13] Dcp-1 CG5370 Drosophila melanogaster (Fruit fly) TR41093_c1_g4_i1 Q5IS99 CASP3_SAIBB 3.00E-34 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Saimiri boliviensis boliviensis (Bolivian squirrel monkey) TR41093_c1_g4_i2 Q8MJC3 CASP3_RABIT 2.00E-36 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Oryctolagus cuniculus (Rabbit) TR41094_c1_g1_i1 Q6GPQ5 DPH1_XENLA 0 GO:0005737; GO:0005634; GO:0017183 cytoplasm; nucleus; peptidyl-diphthamide biosynthetic process from peptidyl-histidine IPR002728; IPR016435; Protein modification; peptidyl-diphthamide biosynthesis. Diphthamide biosynthesis protein 1 (DPH1 homolog) dph1 Xenopus laevis (African clawed frog) TR41094_c1_g1_i2 Q9VVE2 ROGDI_DROME 2.00E-51 GO:0048149; GO:0005635; GO:0008355 P10734 behavioral response to ethanol; nuclear envelope; olfactory learning IPR028241; IPR019386; Protein rogdi rogdi CG7725 Drosophila melanogaster (Fruit fly) TR41094_c1_g1_i4 A7SLX5 DPH1_NEMVE 0 GO:0005737; GO:0017183 cytoplasm; peptidyl-diphthamide biosynthetic process from peptidyl-histidine IPR002728; IPR016435; Protein modification; peptidyl-diphthamide biosynthesis. Diphthamide biosynthesis protein 1 dph1 v1g246101 Nematostella vectensis (Starlet sea anemone) TR41096_c1_g2_i1 Q7KSC4 MPC1_DROME 1.00E-31 GO:0031305; GO:0006850; GO:0006090; GO:0050833 integral to mitochondrial inner membrane; mitochondrial pyruvate transport; pyruvate metabolic process; pyruvate transmembrane transporter activity IPR005336; Mitochondrial pyruvate carrier 1 (MPC1) Mpc1 CG14290 Drosophila melanogaster (Fruit fly) TR41097_c0_g1_i2 P70665 SIAE_MOUSE 1.00E-121 GO:0004091; GO:0005764; GO:0001681 carboxylesterase activity; lysosome; sialate O-acetylesterase activity IPR005181; Sialate O-acetylesterase (EC 3.1.1.53) (Sialic acid-specific 9-O-acetylesterase) (Yolk sac protein 2) [Cleaved into: Sialate O-acetylesterase small subunit; Sialate O-acetylesterase large subunit] Siae Ysg2 Mus musculus (Mouse) TR41098_c2_g1_i3 Q7TPQ9 ARRD3_MOUSE 1.00E-13 GO:0005737; GO:0060613; GO:0031651; GO:0090327; GO:0044252; GO:0071879; GO:0043588; GO:0001659 cytoplasm; fat pad development; negative regulation of heat generation; negative regulation of locomotion involved in locomotory behavior; negative regulation of multicellular organismal metabolic process; positive regulation of adrenergic receptor signaling pathway; skin development; temperature homeostasis IPR011021; IPR011022; IPR014756; Arrestin domain-containing protein 3 Arrdc3 Kiaa1376 Mus musculus (Mouse) TR41101_c0_g5_i2 Q9NR28 DBLOH_HUMAN 7.00E-07 GO:0035631; GO:0008635; GO:0005829; GO:0008625; GO:0009898; GO:0097193; GO:0008631; GO:0005758; GO:0043065 Q13490; Q96CA5; Q05655; P98170 CD40 receptor complex; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; cytosol; extrinsic apoptotic signaling pathway via death domain receptors; internal side of plasma membrane; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to oxidative stress; mitochondrial intermembrane space; positive regulation of apoptotic process IPR015142; IPR009062; "Diablo homolog, mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac)" DIABLO SMAC Homo sapiens (Human) TR41101_c0_g5_i4 Q9NR28 DBLOH_HUMAN 4.00E-11 GO:0035631; GO:0008635; GO:0005829; GO:0008625; GO:0009898; GO:0097193; GO:0008631; GO:0005758; GO:0043065 Q13490; Q96CA5; Q05655; P98170 CD40 receptor complex; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; cytosol; extrinsic apoptotic signaling pathway via death domain receptors; internal side of plasma membrane; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to oxidative stress; mitochondrial intermembrane space; positive regulation of apoptotic process IPR015142; IPR009062; "Diablo homolog, mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac)" DIABLO SMAC Homo sapiens (Human) TR41102_c0_g2_i1 O73683 A4_TETFL 4.00E-32 GO:0008201; GO:0016021; GO:0004867; GO:0046914 heparin binding; integral to membrane; serine-type endopeptidase inhibitor activity; transition metal ion binding IPR008155; IPR013803; IPR011178; IPR024329; IPR008154; IPR019744; IPR015849; IPR019745; IPR019543; IPR002223; Amyloid beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) [Cleaved into: Beta-amyloid protein (A-beta) (Beta-APP)] app Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis) TR41102_c0_g2_i2 Q06481 APLP2_HUMAN 3.00E-30 GO:0003677; GO:0007186; GO:0006878; GO:0008203; GO:0009790; GO:0030198; GO:0030900; GO:0008201; GO:0016021; GO:0007626; GO:0007617; GO:0030901; GO:0050885; GO:0005634; GO:0005886; GO:0007176; GO:0043393; GO:0004867; GO:0001967; GO:0046914 Itself; P51693; P05067-4; O75618; P14921; P05412; Q93074 DNA binding; G-protein coupled receptor signaling pathway; cellular copper ion homeostasis; cholesterol metabolic process; embryo development; extracellular matrix organization; forebrain development; heparin binding; integral to membrane; locomotory behavior; mating behavior; midbrain development; neuromuscular process controlling balance; nucleus; plasma membrane; regulation of epidermal growth factor-activated receptor activity; regulation of protein binding; serine-type endopeptidase inhibitor activity; suckling behavior; transition metal ion binding IPR008155; IPR011178; IPR024329; IPR008154; IPR019744; IPR015849; IPR019745; IPR019543; IPR002223; IPR020901; Amyloid-like protein 2 (APLP-2) (APPH) (Amyloid protein homolog) (CDEI box-binding protein) (CDEBP) APLP2 APPL2 Homo sapiens (Human) TR41102_c0_g2_i3 Q10651 A4_CAEEL 4.00E-29 GO:0010171; GO:0030154; GO:0031410; GO:0042395; GO:0008201; GO:0016021; GO:0002119; GO:0007399; GO:0043005; GO:0043025; GO:0046914 "body morphogenesis; cell differentiation; cytoplasmic vesicle; ecdysis, collagen and cuticulin-based cuticle; heparin binding; integral to membrane; nematode larval development; nervous system development; neuron projection; neuronal cell body; transition metal ion binding" IPR008155; IPR011178; IPR024329; IPR008154; IPR019744; IPR015849; IPR019543; Beta-amyloid-like protein apl-1 C42D8.8 Caenorhabditis elegans TR41102_c0_g2_i4 Q06335 APLP2_MOUSE 9.00E-27 GO:0003677; GO:0006878; GO:0008203; GO:0009790; GO:0030198; GO:0030900; GO:0008201; GO:0016021; GO:0007626; GO:0007617; GO:0030901; GO:0050885; GO:0005634; GO:0005886; GO:0007176; GO:0043393; GO:0001967; GO:0046914 P12023 DNA binding; cellular copper ion homeostasis; cholesterol metabolic process; embryo development; extracellular matrix organization; forebrain development; heparin binding; integral to membrane; locomotory behavior; mating behavior; midbrain development; neuromuscular process controlling balance; nucleus; plasma membrane; regulation of epidermal growth factor-activated receptor activity; regulation of protein binding; suckling behavior; transition metal ion binding IPR008155; IPR011178; IPR024329; IPR008154; IPR019744; IPR015849; IPR019745; IPR019543; Amyloid-like protein 2 (APLP-2) (CDEI box-binding protein) (CDEBP) Aplp2 Mus musculus (Mouse) TR41102_c0_g3_i2 O93279 A4_TAKRU 2.00E-35 GO:0008201; GO:0016021; GO:0004867; GO:0046914 heparin binding; integral to membrane; serine-type endopeptidase inhibitor activity; transition metal ion binding IPR008155; IPR013803; IPR011178; IPR024329; IPR008154; IPR019744; IPR015849; IPR019745; IPR019543; IPR002223; IPR020901; Amyloid beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) [Cleaved into: Beta-amyloid protein (A-beta) (Beta-APP)] app Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR41103_c4_g3_i1 Q8TCJ2 STT3B_HUMAN 0 GO:0030433; GO:0043686; GO:0004579; GO:0006516; GO:0016021; GO:0008250; GO:0043687; GO:0018279; GO:0006986 ER-associated protein catabolic process; co-translational protein modification; dolichyl-diphosphooligosaccharide-protein glycotransferase activity; glycoprotein catabolic process; integral to membrane; oligosaccharyltransferase complex; post-translational protein modification; protein N-linked glycosylation via asparagine; response to unfolded protein IPR003674; Protein modification; protein glycosylation. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Oligosaccharyl transferase subunit STT3B) (STT3-B) (EC 2.4.99.18) (Source of immunodominant MHC-associated peptides homolog) STT3B SIMP Homo sapiens (Human) TR41103_c4_g5_i1 Q2KJI2 STT3A_BOVIN 6.00E-47 GO:0043686; GO:0004579; GO:0016021; GO:0008250; GO:0018279 co-translational protein modification; dolichyl-diphosphooligosaccharide-protein glycotransferase activity; integral to membrane; oligosaccharyltransferase complex; protein N-linked glycosylation via asparagine IPR003674; Protein modification; protein glycosylation. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (Oligosaccharyl transferase subunit STT3A) (STT3-A) (EC 2.4.99.18) STT3A Bos taurus (Bovine) TR41104_c6_g1_i1 P51871 CP4F6_RAT 7.00E-108 GO:0070330; GO:0005789; GO:0020037; GO:0006954; GO:0005506; GO:0006691 aromatase activity; endoplasmic reticulum membrane; heme binding; inflammatory response; iron ion binding; leukotriene metabolic process IPR001128; IPR017972; IPR002403; Cytochrome P450 4F6 (EC 1.14.14.1) (CYPIVF6) Cyp4f6 Rattus norvegicus (Rat) TR41104_c6_g1_i2 A2RRT9 CP4V2_RAT 2.00E-78 GO:0005789; GO:0010430; GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705 "endoplasmic reticulum membrane; fatty acid omega-oxidation; heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Cytochrome P450 4V2 (EC 1.14.13.-) Cyp4v2 Cyp4v3 Rattus norvegicus (Rat) TR41104_c6_g1_i3 P51871 CP4F6_RAT 9.00E-109 GO:0070330; GO:0005789; GO:0020037; GO:0006954; GO:0005506; GO:0006691 aromatase activity; endoplasmic reticulum membrane; heme binding; inflammatory response; iron ion binding; leukotriene metabolic process IPR001128; IPR017972; IPR002403; Cytochrome P450 4F6 (EC 1.14.14.1) (CYPIVF6) Cyp4f6 Rattus norvegicus (Rat) TR41105_c0_g2_i1 O55040 NMUR1_MOUSE 2.00E-07 GO:0005887; GO:0001607; GO:0008188 integral to plasma membrane; neuromedin U receptor activity; neuropeptide receptor activity IPR000276; IPR017452; IPR005390; IPR005391; Neuromedin-U receptor 1 (NMU-R1) (G-protein coupled receptor 66) (G-protein coupled receptor FM-3) Nmur1 Gpr66 Mus musculus (Mouse) TR41105_c0_g2_i7 O55040 NMUR1_MOUSE 3.00E-07 GO:0005887; GO:0001607; GO:0008188 integral to plasma membrane; neuromedin U receptor activity; neuropeptide receptor activity IPR000276; IPR017452; IPR005390; IPR005391; Neuromedin-U receptor 1 (NMU-R1) (G-protein coupled receptor 66) (G-protein coupled receptor FM-3) Nmur1 Gpr66 Mus musculus (Mouse) TR41107_c1_g1_i1 P14381 YTX2_XENLA 1.00E-45 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR41112_c0_g1_i1 Q8NI37 PPTC7_HUMAN 1.00E-76 GO:0008152; GO:0046872; GO:0005739; GO:0004721 metabolic process; metal ion binding; mitochondrion; phosphoprotein phosphatase activity IPR001932; Protein phosphatase PTC7 homolog (EC 3.1.3.16) (T-cell activation protein phosphatase 2C) (TA-PP2C) (T-cell activation protein phosphatase 2C-like) PPTC7 TAPP2C Homo sapiens (Human) TR41112_c1_g1_i1 Q7TQF7 AMPH_MOUSE 2.00E-53 GO:0030054; GO:0005856; GO:0007612; GO:0008021; GO:0048488; GO:0030672 cell junction; cytoskeleton; learning; synaptic vesicle; synaptic vesicle endocytosis; synaptic vesicle membrane IPR027267; IPR003005; IPR003017; IPR004148; IPR001452; Amphiphysin Amph Amph1 Mus musculus (Mouse) TR41112_c1_g1_i2 P50478 AMPH_CHICK 1.00E-53 GO:0030054; GO:0005856; GO:0008021; GO:0030672 cell junction; cytoskeleton; synaptic vesicle; synaptic vesicle membrane IPR027267; IPR003005; IPR003017; IPR004148; IPR001452; Amphiphysin AMPH Gallus gallus (Chicken) TR41114_c0_g3_i1 Q9GP32 ALF_ECHMU 2.00E-172 GO:0004332; GO:0006096 fructose-bisphosphate aldolase activity; glycolysis IPR000741; IPR013785; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. Fructose-bisphosphate aldolase (EC 4.1.2.13) FBPA Echinococcus multilocularis TR41116_c0_g1_i3 P02508 CRYAA_RANTE 3.00E-09 GO:0046872; GO:0005212 metal ion binding; structural constituent of eye lens IPR002068; IPR001436; IPR012274; IPR003090; IPR008978; Alpha-crystallin A chain (Fragment) CRYAA Rana temporaria (European common frog) TR41116_c0_g1_i4 P12812 P40_SCHMA 5.00E-23 IPR002068; IPR001436; IPR008978; Major egg antigen (p40) Schistosoma mansoni (Blood fluke) TR41117_c2_g3_i1 O95758 PTBP3_HUMAN 4.00E-114 GO:0003723; GO:0008380; GO:0009653; GO:0043249; GO:0006397; GO:0033119; GO:0000166; GO:0005634; GO:0045595 RNA binding; RNA splicing; anatomical structure morphogenesis; erythrocyte maturation; mRNA processing; negative regulation of RNA splicing; nucleotide binding; nucleus; regulation of cell differentiation IPR006536; IPR012677; IPR000504; Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) PTBP3 ROD1 Homo sapiens (Human) TR41117_c2_g3_i2 Q6ICX4 PTBP3_ARATH 1.00E-46 GO:0003723; GO:0008380; GO:0000932; GO:0006397; GO:0000166; GO:0005634; GO:0043484; GO:0006417 RNA binding; RNA splicing; cytoplasmic mRNA processing body; mRNA processing; nucleotide binding; nucleus; regulation of RNA splicing; regulation of translation IPR012677; IPR000504; Polypyrimidine tract-binding protein homolog 3 At1g43190 F1I21.14 Arabidopsis thaliana (Mouse-ear cress) TR41117_c2_g3_i3 Q8WVV9 HNRLL_HUMAN 7.00E-25 GO:0003729; GO:0006397; GO:0000166; GO:0005634; GO:0033120; GO:0030529 mRNA binding; mRNA processing; nucleotide binding; nucleus; positive regulation of RNA splicing; ribonucleoprotein complex IPR006536; IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor) HNRNPLL HNRPLL SRRF BLOCK24 Homo sapiens (Human) TR41117_c2_g3_i6 Q66H20 PTBP2_RAT 2.00E-74 GO:0003729; GO:0006376; GO:0033119; GO:0000166; GO:2000177; GO:0005681 mRNA binding; mRNA splice site selection; negative regulation of RNA splicing; nucleotide binding; regulation of neural precursor cell proliferation; spliceosomal complex IPR006536; IPR012677; IPR000504; Polypyrimidine tract-binding protein 2 (Neural polypyrimidine tract-binding protein) (PTB-like protein) Ptbp2 Nptb Ptblp Rattus norvegicus (Rat) TR41117_c2_g3_i9 O95758 PTBP3_HUMAN 7.00E-75 GO:0003723; GO:0008380; GO:0009653; GO:0043249; GO:0006397; GO:0033119; GO:0000166; GO:0005634; GO:0045595 RNA binding; RNA splicing; anatomical structure morphogenesis; erythrocyte maturation; mRNA processing; negative regulation of RNA splicing; nucleotide binding; nucleus; regulation of cell differentiation IPR006536; IPR012677; IPR000504; Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) PTBP3 ROD1 Homo sapiens (Human) TR41118_c3_g3_i1 Q9Y6R7 FCGBP_HUMAN 2.00E-07 GO:0005737; GO:0005576 cytoplasm; extracellular region IPR003645; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) TR41118_c3_g3_i2 Q9Y6R7 FCGBP_HUMAN 6.00E-10 GO:0005737; GO:0005576 cytoplasm; extracellular region IPR003645; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) TR41118_c3_g6_i3 Q90Y54 JAG1B_DANRE 1.00E-08 GO:0007219; GO:0060117; GO:0005509; GO:0060351; GO:0009953; GO:0060325; GO:0016021; GO:0001889; GO:0032474; GO:0031016; GO:0048752; GO:0030878 Notch signaling pathway; auditory receptor cell development; calcium ion binding; cartilage development involved in endochondral bone morphogenesis; dorsal/ventral pattern formation; face morphogenesis; integral to membrane; liver development; otolith morphogenesis; pancreas development; semicircular canal morphogenesis; thyroid gland development IPR001774; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR026219; IPR011651; IPR001007; Protein jagged-1b (Jagged1b) (Jagged3) jag1b jag3 Danio rerio (Zebrafish) (Brachydanio rerio) TR41119_c0_g1_i1 Q5ZMJ9 SRRM1_CHICK 2.00E-21 GO:0008380; GO:0006397; GO:0005634 RNA splicing; mRNA processing; nucleus IPR002483; Serine/arginine repetitive matrix protein 1 SRRM1 RCJMB04_1m21 Gallus gallus (Chicken) TR41119_c0_g1_i4 Q5ZMJ9 SRRM1_CHICK 2.00E-21 GO:0008380; GO:0006397; GO:0005634 RNA splicing; mRNA processing; nucleus IPR002483; Serine/arginine repetitive matrix protein 1 SRRM1 RCJMB04_1m21 Gallus gallus (Chicken) TR41119_c0_g1_i9 Q5ZMJ9 SRRM1_CHICK 1.00E-24 GO:0008380; GO:0006397; GO:0005634 RNA splicing; mRNA processing; nucleus IPR002483; Serine/arginine repetitive matrix protein 1 SRRM1 RCJMB04_1m21 Gallus gallus (Chicken) TR41121_c2_g1_i1 P35623 GLYC_SHEEP 0 GO:0006563; GO:0005737; GO:0004372; GO:0006544; GO:0030170; GO:0035999 L-serine metabolic process; cytoplasm; glycine hydroxymethyltransferase activity; glycine metabolic process; pyridoxal phosphate binding; tetrahydrofolate interconversion IPR015424; IPR015421; IPR015422; IPR001085; IPR019798; One-carbon metabolism; tetrahydrofolate interconversion. "Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)" SHMT1 Ovis aries (Sheep) TR41121_c3_g2_i1 P18395 CSDE1_RAT 4.00E-128 GO:0070937; GO:0003677; GO:0003723; GO:0005743; GO:0070966; GO:0006355 "CRD-mediated mRNA stability complex; DNA binding; RNA binding; mitochondrial inner membrane; nuclear-transcribed mRNA catabolic process, no-go decay; regulation of transcription, DNA-dependent" IPR019844; IPR011129; IPR002059; IPR012340; IPR024642; Cold shock domain-containing protein E1 (Protein UNR) Csde1 Unr Rattus norvegicus (Rat) TR41121_c3_g2_i2 O75534 CSDE1_HUMAN 1.00E-128 GO:0070937; GO:0003677; GO:0003723; GO:0008584; GO:0070966; GO:0006355 "CRD-mediated mRNA stability complex; DNA binding; RNA binding; male gonad development; nuclear-transcribed mRNA catabolic process, no-go decay; regulation of transcription, DNA-dependent" IPR019844; IPR011129; IPR002059; IPR012340; IPR024642; Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) CSDE1 D1S155E KIAA0885 NRU UNR Homo sapiens (Human) TR41121_c3_g2_i5 O75534 CSDE1_HUMAN 2.00E-127 GO:0070937; GO:0003677; GO:0003723; GO:0008584; GO:0070966; GO:0006355 "CRD-mediated mRNA stability complex; DNA binding; RNA binding; male gonad development; nuclear-transcribed mRNA catabolic process, no-go decay; regulation of transcription, DNA-dependent" IPR019844; IPR011129; IPR002059; IPR012340; IPR024642; Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) CSDE1 D1S155E KIAA0885 NRU UNR Homo sapiens (Human) TR41121_c3_g2_i6 P29174 CSDE1_CAVPO 1.00E-29 GO:0070937; GO:0003677; GO:0003723; GO:0005743; GO:0070966; GO:0006355 "CRD-mediated mRNA stability complex; DNA binding; RNA binding; mitochondrial inner membrane; nuclear-transcribed mRNA catabolic process, no-go decay; regulation of transcription, DNA-dependent" IPR011129; IPR002059; IPR012340; IPR024642; Cold shock domain-containing protein E1 (Protein UNR) (Fragment) CSDE1 UNR Cavia porcellus (Guinea pig) TR41123_c1_g2_i1 Q58A42 DD3_DICDI 1.00E-46 GO:0016021 integral to membrane Protein DD3-3 DD3-3 DDB_G0283095 Dictyostelium discoideum (Slime mold) TR41124_c5_g1_i2 Q0VCG0 LYRM4_BOVIN 4.00E-25 GO:0005739; GO:0005634 mitochondrion; nucleus IPR008011; Cofactor biosynthesis; iron-sulfur cluster biosynthesis. LYR motif-containing protein 4 LYRM4 ISD11 Bos taurus (Bovine) TR41124_c6_g1_i1 P08953 TOLL_DROME 9.00E-25 GO:0033565; GO:0008063; GO:0019732; GO:0007155; GO:0019955; GO:0050830; GO:0005769; GO:0009897; GO:0007507; GO:0035172; GO:0030097; GO:0045087; GO:0016021; GO:0006963; GO:0006967; GO:0045610; GO:0007416; GO:0016201; GO:0004888; GO:0007352 Itself; Q7K105 ESCRT-0 complex; Toll signaling pathway; antifungal humoral response; cell adhesion; cytokine binding; defense response to Gram-positive bacterium; early endosome; external side of plasma membrane; heart development; hemocyte proliferation; hemopoiesis; innate immune response; integral to membrane; positive regulation of antibacterial peptide biosynthetic process; positive regulation of antifungal peptide biosynthetic process; regulation of hemocyte differentiation; synapse assembly; synaptic target inhibition; transmembrane signaling receptor activity; zygotic specification of dorsal/ventral axis IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) TR41124_c6_g1_i3 Q689D1 TLR2_CANFA 2.00E-20 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Canis familiaris (Dog) (Canis lupus familiaris) TR41124_c6_g1_i4 Q9MYW3 TLR4_HORSE 1.00E-17 GO:0002755; GO:0050829; GO:0032497; GO:0006954; GO:0045087; GO:0001875; GO:0046696; GO:0042116; GO:0050707; GO:0034142; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-negative bacterium; detection of lipopolysaccharide; inflammatory response; innate immune response; lipopolysaccharide receptor activity; lipopolysaccharide receptor complex; macrophage activation; regulation of cytokine secretion; toll-like receptor 4 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027168; IPR017241; Toll-like receptor 4 (CD antigen CD284) TLR4 Equus caballus (Horse) TR41126_c1_g2_i2 Q9D8X1 CUTC_MOUSE 1.00E-94 GO:0016235; GO:0005507; GO:0055070; GO:0005737; GO:0005730; GO:0051262 aggresome; copper ion binding; copper ion homeostasis; cytoplasm; nucleolus; protein tetramerization IPR005627; IPR023648; Copper homeostasis protein cutC homolog Cutc Mus musculus (Mouse) TR41126_c1_g2_i3 Q9NTM9 CUTC_HUMAN 1.00E-42 GO:0016235; GO:0005507; GO:0055070; GO:0006825; GO:0005737; GO:0005730; GO:0051262 aggresome; copper ion binding; copper ion homeostasis; copper ion transport; cytoplasm; nucleolus; protein tetramerization IPR005627; IPR023648; Copper homeostasis protein cutC homolog CUTC CGI-32 Homo sapiens (Human) TR41126_c1_g3_i3 Q99LC9 PEX6_MOUSE 0 GO:0005524; GO:0042623; GO:0005829; GO:0005778; GO:0016561; GO:0050821 "ATP binding; ATPase activity, coupled; cytosol; peroxisomal membrane; protein import into peroxisome matrix, translocation; protein stabilization" IPR003593; IPR003959; IPR003960; IPR027417; Peroxisome assembly factor 2 (PAF-2) (Peroxin-6) (Peroxisomal biogenesis factor 6) (Peroxisomal-type ATPase 1) Pex6 Mus musculus (Mouse) TR41127_c1_g1_i10 Q6EE23 RSAD2_SINCH 2.00E-155 GO:0051539; GO:0003824; GO:0051607; GO:0005789; GO:0045087; GO:0005811; GO:0008152; GO:0046872 "4 iron, 4 sulfur cluster binding; catalytic activity; defense response to virus; endoplasmic reticulum membrane; innate immune response; lipid particle; metabolic process; metal ion binding" IPR013785; IPR006638; IPR007197; IPR026372; "Radical S-adenosyl methionine domain-containing protein 2 (Viperin) (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible)" rsad2 Siniperca chuatsi (Chinese perch) TR41127_c1_g1_i3 Q6EE23 RSAD2_SINCH 7.00E-156 GO:0051539; GO:0003824; GO:0051607; GO:0005789; GO:0045087; GO:0005811; GO:0008152; GO:0046872 "4 iron, 4 sulfur cluster binding; catalytic activity; defense response to virus; endoplasmic reticulum membrane; innate immune response; lipid particle; metabolic process; metal ion binding" IPR013785; IPR006638; IPR007197; IPR026372; "Radical S-adenosyl methionine domain-containing protein 2 (Viperin) (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible)" rsad2 Siniperca chuatsi (Chinese perch) TR41127_c1_g1_i5 Q6EE23 RSAD2_SINCH 2.00E-155 GO:0051539; GO:0003824; GO:0051607; GO:0005789; GO:0045087; GO:0005811; GO:0008152; GO:0046872 "4 iron, 4 sulfur cluster binding; catalytic activity; defense response to virus; endoplasmic reticulum membrane; innate immune response; lipid particle; metabolic process; metal ion binding" IPR013785; IPR006638; IPR007197; IPR026372; "Radical S-adenosyl methionine domain-containing protein 2 (Viperin) (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible)" rsad2 Siniperca chuatsi (Chinese perch) TR41128_c0_g2_i1 Q8BHG1 NRDC_MOUSE 9.00E-135 GO:0046872; GO:0004222; GO:0005739; GO:0008233; GO:0006508 metal ion binding; metalloendopeptidase activity; mitochondrion; peptidase activity; proteolysis IPR011249; IPR011237; IPR011765; IPR001431; IPR007863; Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) Nrd1 Mus musculus (Mouse) TR41128_c0_g2_i2 O22941 PXM16_ARATH 7.00E-83 GO:0046872; GO:0004222; GO:0005777; GO:0006508 metal ion binding; metalloendopeptidase activity; peroxisome; proteolysis IPR011249; IPR011237; IPR011765; IPR001431; IPR007863; "Zinc-metallopeptidase, peroxisomal (EC 3.4.24.-) (Peroxisomal M16 protease)" PXM16 At2g41790 T11A7.11 Arabidopsis thaliana (Mouse-ear cress) TR41128_c0_g4_i3 O43847 NRDC_HUMAN 1.00E-16 GO:0016477; GO:0008283; GO:0009986; GO:0005829; GO:0048408; GO:0046872; GO:0004222; GO:0007528; GO:0051044; GO:0006508; GO:0052548 P04637 cell migration; cell proliferation; cell surface; cytosol; epidermal growth factor binding; metal ion binding; metalloendopeptidase activity; neuromuscular junction development; positive regulation of membrane protein ectodomain proteolysis; proteolysis; regulation of endopeptidase activity IPR011249; IPR011237; IPR011765; IPR001431; IPR007863; Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) NRD1 Homo sapiens (Human) TR41130_c3_g2_i1 P55245 EGFR_MACMU 9.00E-20 GO:0005524; GO:0000139; GO:0016323; GO:0000902; GO:0008283; GO:0016337; GO:0071392; GO:0021795; GO:0003682; GO:0048546; GO:0001892; GO:0030139; GO:0005789; GO:0005768; GO:0010008; GO:0005006; GO:0001942; GO:0045121; GO:0060571; GO:0043066; GO:0042177; GO:0030235; GO:0031965; GO:0005634; GO:0048471; GO:0045739; GO:0045740; GO:0070374; GO:0043406; GO:0035413; GO:0030335; GO:0031659; GO:0050679; GO:0048146; GO:0045429; GO:0051897; GO:0001934; GO:0045944; GO:0046777; GO:0004713; GO:0050999; GO:0050730; GO:0070141; GO:0007435 ATP binding; Golgi membrane; basolateral plasma membrane; cell morphogenesis; cell proliferation; cell-cell adhesion; cellular response to estradiol stimulus; cerebral cortex cell migration; chromatin binding; digestive tract morphogenesis; embryonic placenta development; endocytic vesicle; endoplasmic reticulum membrane; endosome; endosome membrane; epidermal growth factor-activated receptor activity; hair follicle development; membrane raft; morphogenesis of an epithelial fold; negative regulation of apoptotic process; negative regulation of protein catabolic process; nitric-oxide synthase regulator activity; nuclear membrane; nucleus; perinuclear region of cytoplasm; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAP kinase activity; positive regulation of catenin import into nucleus; positive regulation of cell migration; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of nitric oxide biosynthetic process; positive regulation of protein kinase B signaling cascade; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein autophosphorylation; protein tyrosine kinase activity; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; response to UV-A; salivary gland morphogenesis IPR011009; IPR000719; IPR001245; Epidermal growth factor receptor (EC 2.7.10.1) (Fragment) EGFR Macaca mulatta (Rhesus macaque) TR41130_c3_g2_i2 P23049 SEA_AVIET 2.00E-91 GO:0005524; GO:0004715; GO:0018108 ATP binding; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase transforming protein SEA (EC 2.7.10.2) V-SEA Avian erythroblastosis virus (strain S13) TR41130_c3_g2_i5 P23049 SEA_AVIET 2.00E-91 GO:0005524; GO:0004715; GO:0018108 ATP binding; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase transforming protein SEA (EC 2.7.10.2) V-SEA Avian erythroblastosis virus (strain S13) TR41130_c5_g1_i1 O45657 PLX2_CAEEL 3.00E-07 GO:0030154; GO:0031252; GO:0009986; GO:0009792; GO:0016021; GO:0005622; GO:0002119; GO:0005886; GO:0004872; GO:0007165; GO:0045138 cell differentiation; cell leading edge; cell surface; embryo development ending in birth or egg hatching; integral to membrane; intracellular; nematode larval development; plasma membrane; receptor activity; signal transduction; tail tip morphogenesis IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-2 plx-2 K04B12.1 Caenorhabditis elegans TR41131_c0_g1_i1 Q9R1K8 GRP1_RAT 1.00E-10 GO:0000139; GO:0017034; GO:0032862; GO:0005509; GO:0030154; GO:0001816; GO:0005829; GO:0005789; GO:0002437; GO:0043303; GO:0005886; GO:0014066; GO:0032252; GO:0007264; GO:0047496 Golgi membrane; Rap guanyl-nucleotide exchange factor activity; activation of Rho GTPase activity; calcium ion binding; cell differentiation; cytokine production; cytosol; endoplasmic reticulum membrane; inflammatory response to antigenic stimulus; mast cell degranulation; plasma membrane; regulation of phosphatidylinositol 3-kinase cascade; secretory granule localization; small GTPase mediated signal transduction; vesicle transport along microtubule IPR020454; IPR011992; IPR018247; IPR002048; IPR002219; IPR000651; IPR008937; IPR023578; IPR001895; RAS guanyl-releasing protein 1 (Calcium and DAG-regulated guanine nucleotide exchange factor II) (CalDAG-GEFII) (Ras guanyl-releasing protein) Rasgrp1 Rasgrp Rattus norvegicus (Rat) TR41131_c0_g2_i3 Q16974 KPC1_APLCA 0 GO:0005524; GO:0005737; GO:0035556; GO:0004697; GO:0008270 ATP binding; cytoplasm; intracellular signal transduction; protein kinase C activity; zinc ion binding IPR000961; IPR000008; IPR020454; IPR011009; IPR017892; IPR002219; IPR000719; IPR017441; IPR014375; IPR002290; IPR008271; Calcium-dependent protein kinase C (EC 2.7.11.13) (APL I) PRKC1 Aplysia californica (California sea hare) TR41131_c0_g2_i5 Q12706 PSK1_SCHPO 3.00E-08 GO:0005524; GO:0004693; GO:0005829; GO:0007165 ATP binding; cyclin-dependent protein serine/threonine kinase activity; cytosol; signal transduction IPR000961; IPR011009; IPR000719; IPR002290; IPR008271; Serine/threonine-protein kinase psk1 (EC 2.7.11.22) psk1 SPCC4G3.08 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41131_c0_g2_i6 Q02956 KPCZ_MOUSE 8.00E-18 GO:0005524; GO:0045179; GO:0016324; GO:0043203; GO:0005768; GO:0030010; GO:0006954; GO:0035556; GO:0060291; GO:0000226; GO:0005815; GO:0035748; GO:0046627; GO:0050732; GO:0031333; GO:1990138; GO:0005635; GO:0016363; GO:0018105; GO:0070374; GO:0051092; GO:2000553; GO:0045630; GO:2000463; GO:0046628; GO:2001181; GO:2000667; GO:0032753; GO:2000664; GO:0043234; GO:0004697; GO:0072659; GO:0004674; GO:0005923; GO:0008270 ATP binding; apical cortex; apical plasma membrane; axon hillock; endosome; establishment of cell polarity; inflammatory response; intracellular signal transduction; long-term synaptic potentiation; microtubule cytoskeleton organization; microtubule organizing center; myelin sheath abaxonal region; negative regulation of insulin receptor signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein complex assembly; neuron projection extension; nuclear envelope; nuclear matrix; peptidyl-serine phosphorylation; positive regulation of ERK1 and ERK2 cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of T-helper 2 cell cytokine production; positive regulation of T-helper 2 cell differentiation; positive regulation of excitatory postsynaptic membrane potential; positive regulation of insulin receptor signaling pathway; positive regulation of interleukin-10 secretion; positive regulation of interleukin-13 secretion; positive regulation of interleukin-4 production; positive regulation of interleukin-5 secretion; protein complex; protein kinase C activity; protein localization to plasma membrane; protein serine/threonine kinase activity; tight junction; zinc ion binding IPR000961; IPR020454; IPR011009; IPR000270; IPR012233; IPR017892; IPR002219; IPR000719; IPR017441; IPR002290; IPR008271; Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) Prkcz Pkcz Mus musculus (Mouse) TR41131_c0_g3_i1 Q16974 KPC1_APLCA 2.00E-158 GO:0005524; GO:0005737; GO:0035556; GO:0004697; GO:0008270 ATP binding; cytoplasm; intracellular signal transduction; protein kinase C activity; zinc ion binding IPR000961; IPR000008; IPR020454; IPR011009; IPR017892; IPR002219; IPR000719; IPR017441; IPR014375; IPR002290; IPR008271; Calcium-dependent protein kinase C (EC 2.7.11.13) (APL I) PRKC1 Aplysia californica (California sea hare) TR41132_c1_g1_i1 Q3T033 MSPD3_BOVIN 3.00E-39 GO:0016021; GO:0005198 integral to membrane; structural molecule activity IPR000535; IPR008962; Motile sperm domain-containing protein 3 MOSPD3 Bos taurus (Bovine) TR41132_c1_g1_i2 Q8VEL0 MSPD1_MOUSE 6.00E-63 GO:0016021; GO:0000122; GO:0005634; GO:0048471; GO:0045944; GO:0005198 integral to membrane; negative regulation of transcription from RNA polymerase II promoter; nucleus; perinuclear region of cytoplasm; positive regulation of transcription from RNA polymerase II promoter; structural molecule activity IPR000535; IPR008962; Motile sperm domain-containing protein 1 Mospd1 Mus musculus (Mouse) TR41132_c1_g1_i5 Q9UJG1 MSPD1_HUMAN 5.00E-63 GO:0016021; GO:0000122; GO:0005634; GO:0048471; GO:0045944; GO:0005198 integral to membrane; negative regulation of transcription from RNA polymerase II promoter; nucleus; perinuclear region of cytoplasm; positive regulation of transcription from RNA polymerase II promoter; structural molecule activity IPR000535; IPR008962; Motile sperm domain-containing protein 1 MOSPD1 Homo sapiens (Human) TR41135_c1_g1_i2 P89116 CASP1_SPOFR 1.00E-06 GO:0006915; GO:0004197; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-1 (EC 3.4.22.-) [Cleaved into: Caspase-1 subunit p19/18; Caspase-1 subunit p12] Spodoptera frugiperda (Fall armyworm) TR41135_c1_g1_i4 P55213 CASP3_RAT 4.00E-11 GO:0071407; GO:0004197; GO:0008234; GO:0005829; GO:0034349; GO:0021766; GO:0035556; GO:0007611; GO:0030182; GO:0016005; GO:0043525; GO:0006508; GO:0010165; GO:0043200; GO:0046677; GO:0032025; GO:0042493; GO:0032355; GO:0051384; GO:0009749; GO:0042542; GO:0001666; GO:0032496; GO:0035094; GO:0042060 cellular response to organic cyclic compound; cysteine-type endopeptidase activity; cysteine-type peptidase activity; cytosol; glial cell apoptotic process; hippocampus development; intracellular signal transduction; learning or memory; neuron differentiation; phospholipase A2 activator activity; positive regulation of neuron apoptotic process; proteolysis; response to X-ray; response to amino acid stimulus; response to antibiotic; response to cobalt ion; response to drug; response to estradiol stimulus; response to glucocorticoid stimulus; response to glucose stimulus; response to hydrogen peroxide; response to hypoxia; response to lipopolysaccharide; response to nicotine; wound healing IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (IRP) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] Casp3 Cpp32 Rattus norvegicus (Rat) TR41135_c1_g1_i5 Q92851 CASPA_HUMAN 1.00E-08 GO:0097190; GO:0004197; GO:0005829; GO:0045087; GO:0005886; GO:0043123; GO:0006508; GO:0042981; GO:0097342 Q14790; O15519; O14730; Q13546 apoptotic signaling pathway; cysteine-type endopeptidase activity; cytosol; innate immune response; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteolysis; regulation of apoptotic process; ripoptosome IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] CASP10 MCH4 Homo sapiens (Human) TR41136_c0_g1_i1 Q68SA9 ATS7_MOUSE 7.00E-70 GO:0009986; GO:0004222; GO:0008237; GO:0005578; GO:0006508; GO:0008270 cell surface; metalloendopeptidase activity; metallopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS 7) (ADAM-TS7) (ADAMTS-7) (EC 3.4.24.-) (COMPase) Adamts7 Mus musculus (Mouse) TR41136_c0_g2_i1 Q9UKP4 ATS7_HUMAN 1.00E-131 GO:0009986; GO:0004222; GO:0008237; GO:0005578; GO:0006508; GO:0008270 cell surface; metalloendopeptidase activity; metallopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS 7) (ADAM-TS7) (ADAMTS-7) (EC 3.4.24.-) (COMPase) ADAMTS7 Homo sapiens (Human) TR41136_c1_g1_i2 Q3UHD1 BAI1_MOUSE 3.00E-06 GO:0004930; GO:0016021; GO:0016525; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; negative regulation of angiogenesis; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR008077; IPR001879; IPR000832; IPR000203; IPR000884; Brain-specific angiogenesis inhibitor 1 Bai1 Mus musculus (Mouse) TR41138_c1_g1_i2 Q61739 ITA6_MOUSE 4.00E-110 GO:0009925; GO:0005604; GO:0050873; GO:0033627; GO:0007160; GO:0031668; GO:0009897; GO:0046847; GO:0030056; GO:0008305; GO:0007229; GO:0050900; GO:0046872; GO:0042475; GO:0022409 basal plasma membrane; basement membrane; brown fat cell differentiation; cell adhesion mediated by integrin; cell-matrix adhesion; cellular response to extracellular stimulus; external side of plasma membrane; filopodium assembly; hemidesmosome; integrin complex; integrin-mediated signaling pathway; leukocyte migration; metal ion binding; odontogenesis of dentin-containing tooth; positive regulation of cell-cell adhesion IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain] Itga6 Mus musculus (Mouse) TR41138_c1_g1_i3 Q5R7L8 BL1S1_PONAB 8.00E-39 GO:0031083; GO:0009060; GO:0008089; GO:0048490; GO:0005758; GO:0005759; GO:0031175; GO:0018394 BLOC-1 complex; aerobic respiration; anterograde axon cargo transport; anterograde synaptic vesicle transport; mitochondrial intermembrane space; mitochondrial matrix; neuron projection development; peptidyl-lysine acetylation IPR009395; Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC-1 subunit 1) BLOC1S1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41139_c2_g3_i1 P37167 ACTP_ACACA 2.00E-25 GO:0015629; GO:0030042; GO:0005737 actin cytoskeleton; actin filament depolymerization; cytoplasm IPR002108; IPR017904; Actophorin Acanthamoeba castellanii (Amoeba) TR41139_c2_g3_i3 P37167 ACTP_ACACA 2.00E-25 GO:0015629; GO:0030042; GO:0005737 actin cytoskeleton; actin filament depolymerization; cytoplasm IPR002108; IPR017904; Actophorin Acanthamoeba castellanii (Amoeba) TR41140_c0_g1_i1 C3XVT5 LIS1_BRAFL 0 GO:0051301; GO:0006928; GO:0005737; GO:0000132; GO:0005874; GO:0005875; GO:0005815; GO:0007067; GO:0006810 cell division; cellular component movement; cytoplasm; establishment of mitotic spindle orientation; microtubule; microtubule associated complex; microtubule organizing center; mitosis; transport IPR017252; IPR020472; IPR006594; IPR013720; IPR015943; IPR001680; IPR019775; IPR017986; Lissencephaly-1 homolog BRAFLDRAFT_59218 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR41140_c0_g1_i2 C3XVT5 LIS1_BRAFL 0 GO:0051301; GO:0006928; GO:0005737; GO:0000132; GO:0005874; GO:0005875; GO:0005815; GO:0007067; GO:0006810 cell division; cellular component movement; cytoplasm; establishment of mitotic spindle orientation; microtubule; microtubule associated complex; microtubule organizing center; mitosis; transport IPR017252; IPR020472; IPR006594; IPR013720; IPR015943; IPR001680; IPR019775; IPR017986; Lissencephaly-1 homolog BRAFLDRAFT_59218 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR41140_c0_g1_i3 Q5EA99 PK1IP_BOVIN 3.00E-07 GO:0009968; GO:0005730 negative regulation of signal transduction; nucleolus IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; p21-activated protein kinase-interacting protein 1 (PAK1-interacting protein 1) PAK1IP1 Bos taurus (Bovine) TR41140_c0_g1_i4 P20484 MAK11_YEAST 1.00E-08 GO:0000466; GO:0000463; GO:0016020; GO:0031965; GO:0005730; GO:0000027 "maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); membrane; nuclear membrane; nucleolus; ribosomal large subunit assembly" IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Protein MAK11 (Maintenance of killer protein 11) MAK11 YKL021C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41141_c1_g1_i1 Q94126 CES2_CAEEL 2.00E-18 GO:0001012; GO:0006915; GO:0005634; GO:0043068; GO:0043565; GO:0003700; GO:0006351 "RNA polymerase II regulatory region DNA binding; apoptotic process; nucleus; positive regulation of programmed cell death; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; Cell death specification protein 2 ces-2 ZK909.4 Caenorhabditis elegans TR41142_c1_g2_i1 Q0WYX8 MDGA1_CHICK 8.00E-18 GO:0046658; GO:0001764 anchored to plasma membrane; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 MDGA1 Gallus gallus (Chicken) TR41142_c1_g2_i2 P60755 MDGA2_MOUSE 4.00E-16 GO:0031225; GO:0007389; GO:0005886 anchored to membrane; pattern specification process; plasma membrane IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 2 (MAM domain-containing protein 1) Mdga2 Mamdc1 Mus musculus (Mouse) TR41142_c1_g3_i3 Q91641 THIB_XENLA 1.00E-07 GO:0005615; GO:0016020; GO:0007275 extracellular space; membrane; multicellular organismal development IPR008985; IPR000998; Thyroid hormone-induced protein B Xenopus laevis (African clawed frog) TR41144_c2_g1_i1 P10775 RINI_PIG 3.00E-21 GO:0005737 cytoplasm IPR001611; IPR025875; IPR003590; Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) RNH1 RI RNH Sus scrofa (Pig) TR41144_c2_g1_i2 Q288C4 NALP9_BOVIN 2.00E-10 GO:0005524; GO:0005737 ATP binding; cytoplasm IPR004020; IPR011029; IPR007111; IPR027417; "NACHT, LRR and PYD domains-containing protein 9" NLRP9 NALP9 Bos taurus (Bovine) TR41144_c2_g1_i4 Q647I9 NALP5_BOVIN 6.00E-20 GO:0005524; GO:0005739; GO:0005730; GO:0017111 ATP binding; mitochondrion; nucleolus; nucleoside-triphosphatase activity IPR003593; IPR004020; IPR011029; IPR007111; IPR027417; "NACHT, LRR and PYD domains-containing protein 5 (Mater protein homolog)" NLRP5 MATER NALP5 Bos taurus (Bovine) TR41144_c2_g1_i5 Q91VI7 RINI_MOUSE 5.00E-22 GO:0032311; GO:0005737; GO:0045765; GO:0008428 angiogenin-PRI complex; cytoplasm; regulation of angiogenesis; ribonuclease inhibitor activity IPR003590; Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) Rnh1 Rnh Mus musculus (Mouse) TR41147_c0_g2_i1 Q6ZN04 MEX3B_HUMAN 3.00E-88 GO:0003723; GO:0005509; GO:0005737; GO:0000932; GO:0005634; GO:0046777; GO:0008270 RNA binding; calcium ion binding; cytoplasm; cytoplasmic mRNA processing body; nucleus; protein autophosphorylation; zinc ion binding IPR004087; IPR004088; IPR001841; IPR013083; RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195) MEX3B KIAA2009 RKHD3 RNF195 Homo sapiens (Human) TR41147_c0_g2_i2 Q6ZN04 MEX3B_HUMAN 2.00E-88 GO:0003723; GO:0005509; GO:0005737; GO:0000932; GO:0005634; GO:0046777; GO:0008270 RNA binding; calcium ion binding; cytoplasm; cytoplasmic mRNA processing body; nucleus; protein autophosphorylation; zinc ion binding IPR004087; IPR004088; IPR001841; IPR013083; RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195) MEX3B KIAA2009 RKHD3 RNF195 Homo sapiens (Human) TR41148_c1_g4_i1 Q0VA61 HYOU1_XENTR 0 GO:0005524; GO:0005788 ATP binding; endoplasmic reticulum lumen IPR018181; IPR013126; Hypoxia up-regulated protein 1 (Fragment) hyou1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41148_c1_g4_i5 Q0VA61 HYOU1_XENTR 0 GO:0005524; GO:0005788 ATP binding; endoplasmic reticulum lumen IPR018181; IPR013126; Hypoxia up-regulated protein 1 (Fragment) hyou1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41151_c4_g1_i1 Q9HC56 PCDH9_HUMAN 3.00E-107 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR013164; IPR013585; Protocadherin-9 PCDH9 Homo sapiens (Human) TR41151_c4_g1_i3 Q9HC56 PCDH9_HUMAN 2.00E-108 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR013164; IPR013585; Protocadherin-9 PCDH9 Homo sapiens (Human) TR41151_c4_g1_i5 Q03763 DSG1_BOVIN 2.00E-17 GO:0005509; GO:0030057; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; desmosome; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR000233; IPR027397; IPR009123; IPR009122; Desmoglein-1 (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen) DSG1 Bos taurus (Bovine) TR41152_c1_g2_i1 Q9UBU6 FA8A1_HUMAN 4.00E-29 GO:0016021 integral to membrane IPR010432; Protein FAM8A1 (Autosomal highly conserved protein) FAM8A1 AHCP Homo sapiens (Human) TR41152_c1_g2_i2 Q9UBU6 FA8A1_HUMAN 6.00E-28 GO:0016021 integral to membrane IPR010432; Protein FAM8A1 (Autosomal highly conserved protein) FAM8A1 AHCP Homo sapiens (Human) TR41153_c1_g1_i1 P04179 SODM_HUMAN 2.00E-81 GO:0003677; GO:0001315; GO:0071361; GO:0003032; GO:0048773; GO:0006749; GO:0007507; GO:0030097; GO:0050665; GO:0055072; GO:0001889; GO:0007626; GO:0030145; GO:0005743; GO:0005759; GO:0042645; GO:0008285; GO:0045599; GO:0048147; GO:1902176; GO:0043524; GO:0048666; GO:0019825; GO:0032364; GO:0045429; GO:0009791; GO:0051289; GO:0050790; GO:0051881; GO:0006357; GO:0001836; GO:0019430; GO:0022904; GO:0033591; GO:0014823; GO:0048678; GO:0046686; GO:0042493; GO:0051602; GO:0010332; GO:0042542; GO:0055093; GO:0001666; GO:0032496; GO:0010042; GO:0010269; GO:0034021; GO:0010043; GO:0042554; GO:0004784; GO:0003069 Itself DNA binding; age-dependent response to reactive oxygen species; cellular response to ethanol; detection of oxygen; erythrophore differentiation; glutathione metabolic process; heart development; hemopoiesis; hydrogen peroxide biosynthetic process; iron ion homeostasis; liver development; locomotory behavior; manganese ion binding; mitochondrial inner membrane; mitochondrial matrix; mitochondrial nucleoid; negative regulation of cell proliferation; negative regulation of fat cell differentiation; negative regulation of fibroblast proliferation; negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress; negative regulation of neuron apoptotic process; neuron development; oxygen binding; oxygen homeostasis; positive regulation of nitric oxide biosynthetic process; post-embryonic development; protein homotetramerization; regulation of catalytic activity; regulation of mitochondrial membrane potential; regulation of transcription from RNA polymerase II promoter; release of cytochrome c from mitochondria; removal of superoxide radicals; respiratory electron transport chain; response to L-ascorbic acid; response to activity; response to axon injury; response to cadmium ion; response to drug; response to electrical stimulus; response to gamma radiation; response to hydrogen peroxide; response to hyperoxia; response to hypoxia; response to lipopolysaccharide; response to manganese ion; response to selenium ion; response to silicon dioxide; response to zinc ion; superoxide anion generation; superoxide dismutase activity; vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure IPR001189; IPR019833; IPR019832; IPR019831; "Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1)" SOD2 Homo sapiens (Human) TR41153_c1_g1_i2 P41976 SODM_BOVIN 5.00E-80 GO:0001315; GO:0003032; GO:0048773; GO:0006749; GO:0007507; GO:0030097; GO:0055072; GO:0001889; GO:0007626; GO:0030145; GO:0005743; GO:0005759; GO:0043066; GO:0045599; GO:0048147; GO:0048666; GO:0045429; GO:0009791; GO:0050790; GO:0051881; GO:0006357; GO:0001836; GO:0019430; GO:0022904; GO:0014823; GO:0048678; GO:0010332; GO:0042542; GO:0055093; GO:0042554; GO:0004784; GO:0006801; GO:0003069 age-dependent response to reactive oxygen species; detection of oxygen; erythrophore differentiation; glutathione metabolic process; heart development; hemopoiesis; iron ion homeostasis; liver development; locomotory behavior; manganese ion binding; mitochondrial inner membrane; mitochondrial matrix; negative regulation of apoptotic process; negative regulation of fat cell differentiation; negative regulation of fibroblast proliferation; neuron development; positive regulation of nitric oxide biosynthetic process; post-embryonic development; regulation of catalytic activity; regulation of mitochondrial membrane potential; regulation of transcription from RNA polymerase II promoter; release of cytochrome c from mitochondria; removal of superoxide radicals; respiratory electron transport chain; response to activity; response to axon injury; response to gamma radiation; response to hydrogen peroxide; response to hyperoxia; superoxide anion generation; superoxide dismutase activity; superoxide metabolic process; vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure IPR001189; IPR019833; IPR019832; IPR019831; "Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1)" SOD2 Bos taurus (Bovine) TR41155_c0_g2_i1 Q32L50 SBSPO_BOVIN 2.00E-28 GO:0006955; GO:0030247; GO:0005578; GO:0005044 immune response; polysaccharide binding; proteinaceous extracellular matrix; scavenger receptor activity IPR001212; IPR000884; Somatomedin-B and thrombospondin type-1 domain-containing protein (RPE-spondin) SBSPON RPESP Bos taurus (Bovine) TR41156_c0_g1_i1 Q8AVU9 EMC2B_XENLA 1.00E-65 GO:0072546; GO:0005634 ER membrane protein complex; nucleus IPR013026; IPR011990; IPR019734; ER membrane protein complex subunit 2-B (Tetratricopeptide repeat protein 35-B) (TPR repeat protein 35-B) emc2-b ttc35-b Xenopus laevis (African clawed frog) TR41156_c0_g1_i7 Q6INS3 EMC2A_XENLA 5.00E-74 GO:0072546; GO:0005634 ER membrane protein complex; nucleus IPR013026; IPR011990; IPR019734; ER membrane protein complex subunit 2-A (Tetratricopeptide repeat protein 35-A) (TPR repeat protein 35-A) emc2-a ttc35-a Xenopus laevis (African clawed frog) TR41157_c0_g1_i1 Q8N2G6 ZCH24_HUMAN 1.00E-76 GO:0003676; GO:0008270 nucleic acid binding; zinc ion binding IPR025829; IPR027377; IPR001878; Zinc finger CCHC domain-containing protein 24 ZCCHC24 C10orf56 Homo sapiens (Human) TR41159_c0_g2_i2 O34355 YTCJ_BACSU 3.00E-29 GO:0016810 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds" IPR013108; IPR011059; Putative amidohydrolase YtcJ (EC 3.5.-.-) ytcJ BSU29550 Bacillus subtilis (strain 168) TR41161_c2_g1_i1 O46404 P55G_BOVIN 4.00E-97 GO:0005942; GO:0035014; GO:0043551 phosphatidylinositol 3-kinase complex; phosphatidylinositol 3-kinase regulator activity; regulation of phosphatidylinositol 3-kinase activity IPR001720; IPR000980; Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit gamma) (PI3-kinase subunit p85-gamma) (PtdIns-3-kinase regulatory subunit p85-gamma) (p55PIK) PIK3R3 Bos taurus (Bovine) TR41161_c4_g1_i1 Q7ZUP1 FA46C_DANRE 1.00E-148 IPR012937; Protein FAM46C fam46c zgc:55510 Danio rerio (Zebrafish) (Brachydanio rerio) TR41161_c4_g3_i1 Q5XIV0 FA46C_RAT 2.00E-14 IPR012937; Protein FAM46C Fam46c Rattus norvegicus (Rat) TR41162_c0_g1_i1 P30044 PRDX5_HUMAN 1.00E-43 GO:0070995; GO:0001016; GO:0016209; GO:0034614; GO:0043027; GO:0031410; GO:0005829; GO:0042744; GO:0006954; GO:0005739; GO:0043066; GO:0051354; GO:0016480; GO:0005634; GO:0048471; GO:0004601; GO:0051920; GO:0005782; GO:0005777; GO:0072541; GO:0032967; GO:0046983; GO:2001057; GO:0060785 NADPH oxidation; RNA polymerase III regulatory region DNA binding; antioxidant activity; cellular response to reactive oxygen species; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasmic vesicle; cytosol; hydrogen peroxide catabolic process; inflammatory response; mitochondrion; negative regulation of apoptotic process; negative regulation of oxidoreductase activity; negative regulation of transcription from RNA polymerase III promoter; nucleus; perinuclear region of cytoplasm; peroxidase activity; peroxiredoxin activity; peroxisomal matrix; peroxisome; peroxynitrite reductase activity; positive regulation of collagen biosynthetic process; protein dimerization activity; reactive nitrogen species metabolic process; regulation of apoptosis involved in tissue homeostasis IPR013740; IPR012336; "Peroxiredoxin-5, mitochondrial (EC 1.11.1.15) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin reductase)" PRDX5 ACR1 SBBI10 Homo sapiens (Human) TR41162_c0_g1_i9 P30044 PRDX5_HUMAN 1.00E-43 GO:0070995; GO:0001016; GO:0016209; GO:0034614; GO:0043027; GO:0031410; GO:0005829; GO:0042744; GO:0006954; GO:0005739; GO:0043066; GO:0051354; GO:0016480; GO:0005634; GO:0048471; GO:0004601; GO:0051920; GO:0005782; GO:0005777; GO:0072541; GO:0032967; GO:0046983; GO:2001057; GO:0060785 NADPH oxidation; RNA polymerase III regulatory region DNA binding; antioxidant activity; cellular response to reactive oxygen species; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasmic vesicle; cytosol; hydrogen peroxide catabolic process; inflammatory response; mitochondrion; negative regulation of apoptotic process; negative regulation of oxidoreductase activity; negative regulation of transcription from RNA polymerase III promoter; nucleus; perinuclear region of cytoplasm; peroxidase activity; peroxiredoxin activity; peroxisomal matrix; peroxisome; peroxynitrite reductase activity; positive regulation of collagen biosynthetic process; protein dimerization activity; reactive nitrogen species metabolic process; regulation of apoptosis involved in tissue homeostasis IPR013740; IPR012336; "Peroxiredoxin-5, mitochondrial (EC 1.11.1.15) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin reductase)" PRDX5 ACR1 SBBI10 Homo sapiens (Human) TR41163_c1_g1_i1 O95198 KLHL2_HUMAN 2.00E-09 GO:0031463; GO:0003779; GO:0015629; GO:0005737; GO:0005829; GO:0030027; GO:0016567; GO:0001726 Cul3-RING ubiquitin ligase complex; actin binding; actin cytoskeleton; cytoplasm; cytosol; lamellipodium; protein ubiquitination; ruffle IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 2 (Actin-binding protein Mayven) KLHL2 Homo sapiens (Human) TR41163_c1_g1_i3 O95198 KLHL2_HUMAN 1.00E-10 GO:0031463; GO:0003779; GO:0015629; GO:0005737; GO:0005829; GO:0030027; GO:0016567; GO:0001726 Cul3-RING ubiquitin ligase complex; actin binding; actin cytoskeleton; cytoplasm; cytosol; lamellipodium; protein ubiquitination; ruffle IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 2 (Actin-binding protein Mayven) KLHL2 Homo sapiens (Human) TR41163_c1_g1_i4 Q5ZJU2 KLH15_CHICK 1.00E-08 GO:0016567 protein ubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR015915; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 15 KLHL15 RCJMB04_15l4 Gallus gallus (Chicken) TR41164_c4_g1_i3 Q5I2E5 FCN2_BOVIN 2.00E-38 GO:0005581; GO:0001867 "collagen; complement activation, lectin pathway" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) FCN2 Bos taurus (Bovine) TR41164_c4_g1_i4 E2IYB3 FCNV1_VARKO 1.00E-15 GO:0005576 extracellular region IPR008160; IPR014716; IPR002181; Veficolin-1 (Fragment) Varanus komodoensis (Komodo dragon) TR41164_c4_g1_i6 P21520 SCA_DROME 4.00E-34 GO:0007219; GO:0007460; GO:0005576; GO:0016321; GO:0008587; GO:0005770; GO:0046331; GO:0016318; GO:0045468; GO:0097305; GO:0004871 Notch signaling pathway; R8 cell fate commitment; extracellular region; female meiosis chromosome segregation; imaginal disc-derived wing margin morphogenesis; late endosome; lateral inhibition; ommatidial rotation; regulation of R8 cell spacing in compound eye; response to alcohol; signal transducer activity IPR014716; IPR014715; IPR002181; IPR020837; Protein scabrous sca CG17579 Drosophila melanogaster (Fruit fly) TR41164_c4_g1_i9 Q1RMR1 ANGL1_BOVIN 4.00E-42 GO:0005615; GO:0007169 extracellular space; transmembrane receptor protein tyrosine kinase signaling pathway IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-related protein 1 (Angiopoietin-like protein 1) ANGPTL1 Bos taurus (Bovine) TR41166_c3_g1_i1 Q14692 BMS1_HUMAN 0 GO:0005524; GO:0005730; GO:0042255 ATP binding; nucleolus; ribosome assembly IPR012948; IPR007034; IPR027417; Ribosome biogenesis protein BMS1 homolog (Ribosome assembly protein BMS1 homolog) BMS1 BMS1L KIAA0187 Homo sapiens (Human) TR41168_c0_g1_i1 P36586 YPT5_SCHPO 3.00E-14 GO:0070314; GO:0005525; GO:0003924; GO:0006995; GO:0005829; GO:0006897; GO:0005770; GO:0005634; GO:0005886; GO:0015031; GO:0033157; GO:0031338; GO:0007264 G1 to G0 transition; GTP binding; GTPase activity; cellular response to nitrogen starvation; cytosol; endocytosis; late endosome; nucleus; plasma membrane; protein transport; regulation of intracellular protein transport; regulation of vesicle fusion; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; GTP-binding protein ypt5 ypt5 SPAC6F6.15 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41168_c0_g1_i2 P38542 RAN_BRUMA 3.00E-119 GO:0005525; GO:0003924; GO:0006886; GO:0006913; GO:0005634; GO:0007264 GTP binding; GTPase activity; intracellular protein transport; nucleocytoplasmic transport; nucleus; small GTPase mediated signal transduction IPR027417; IPR002041; IPR005225; IPR001806; GTP-binding nuclear protein Ran (GTPase Ran) (Ras-like protein TC4) Bm1_44725 Brugia malayi (Filarial nematode worm) TR41168_c0_g1_i4 Q9VZ23 RAN_DROME 2.00E-89 GO:0005525; GO:0003924; GO:0007015; GO:0007155; GO:0051301; GO:0006886; GO:0005811; GO:0000212; GO:0005875; GO:0007067; GO:0072686; GO:0048812; GO:0005880; GO:0006913; GO:0008360; GO:0007264 GTP binding; GTPase activity; actin filament organization; cell adhesion; cell division; intracellular protein transport; lipid particle; meiotic spindle organization; microtubule associated complex; mitosis; mitotic spindle; neuron projection morphogenesis; nuclear microtubule; nucleocytoplasmic transport; regulation of cell shape; small GTPase mediated signal transduction IPR027417; IPR002041; IPR005225; IPR001806; GTP-binding nuclear protein Ran (Ras-related nuclear protein) ran Ran10A CG1404 Drosophila melanogaster (Fruit fly) TR41169_c1_g1_i1 P97798 NEO1_MOUSE 3.00E-14 GO:0045296; GO:0007155; GO:0016021; GO:0007520; GO:0005886; GO:0004872; GO:0006355 F8VQB6 "cadherin binding; cell adhesion; integral to membrane; myoblast fusion; plasma membrane; receptor activity; regulation of transcription, DNA-dependent" IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR010560; Neogenin Neo1 Ngn Mus musculus (Mouse) TR41169_c1_g1_i2 Q7T2H2 FGRL1_CHICK 5.00E-32 GO:0060539; GO:0005007; GO:0003179; GO:0008201; GO:0016021; GO:0008285; GO:0005886; GO:0001501; GO:0060412 diaphragm development; fibroblast growth factor-activated receptor activity; heart valve morphogenesis; heparin binding; integral to membrane; negative regulation of cell proliferation; plasma membrane; skeletal system development; ventricular septum morphogenesis IPR007110; IPR013783; IPR013098; IPR003598; Fibroblast growth factor receptor-like 1 FGFRL1 Gallus gallus (Chicken) TR41169_c1_g1_i4 Q92859 NEO1_HUMAN 4.00E-14 GO:0007411; GO:0007155; GO:0005887; GO:0055072; GO:0042692; GO:0007520; GO:0051149; GO:0004872; GO:0006355 "axon guidance; cell adhesion; integral to plasma membrane; iron ion homeostasis; muscle cell differentiation; myoblast fusion; positive regulation of muscle cell differentiation; receptor activity; regulation of transcription, DNA-dependent" IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR010560; Neogenin (Immunoglobulin superfamily DCC subclass member 2) NEO1 IGDCC2 NGN Homo sapiens (Human) TR41169_c1_g1_i6 P10586 PTPRF_HUMAN 6.00E-15 GO:0007155; GO:0008201; GO:0005887; GO:0005001; GO:0007185 cell adhesion; heparin binding; integral to plasma membrane; transmembrane receptor protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase signaling pathway IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) PTPRF LAR Homo sapiens (Human) TR41169_c1_g4_i1 Q90330 FGFR4_COTCO 3.00E-17 GO:0005524; GO:0005783; GO:0005768; GO:0005007; GO:0016021; GO:0018108; GO:0005886; GO:0008284 ATP binding; endoplasmic reticulum; endosome; fibroblast growth factor-activated receptor activity; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; positive regulation of cell proliferation IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (Fibroblast growth factor receptor-like embryonic kinase) FGFR4 FREK Coturnix coturnix (Common quail) (Tetrao coturnix) TR41170_c0_g4_i1 Q9HD45 TM9S3_HUMAN 7.00E-166 GO:0016021 integral to membrane IPR004240; Transmembrane 9 superfamily member 3 (EP70-P-iso) (SM-11044-binding protein) TM9SF3 SMBP UNQ245/PRO282 Homo sapiens (Human) TR41170_c0_g4_i2 Q7YTA6 PHG1C_DICDI 2.00E-25 GO:0005887; GO:0006909; GO:0004888 integral to plasma membrane; phagocytosis; transmembrane signaling receptor activity IPR004240; Putative phagocytic receptor 1c phg1c DDB_G0290159 Dictyostelium discoideum (Slime mold) TR41172_c5_g1_i1 Q5ZEQ8 FJX1_XIPMA 1.00E-34 GO:0005576 extracellular region IPR009581; IPR024868; Four-jointed box protein 1 (Four-jointed protein homolog) fjx1 Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) TR41172_c5_g1_i2 Q8BQB4 FJX1_MOUSE 2.00E-30 GO:0005615 extracellular space IPR009581; IPR024868; Four-jointed box protein 1 (Four-jointed protein x1) (Four-jointed protein homolog) Fjx1 Mus musculus (Mouse) TR41172_c5_g1_i4 Q8BQB4 FJX1_MOUSE 2.00E-30 GO:0005615 extracellular space IPR009581; IPR024868; Four-jointed box protein 1 (Four-jointed protein x1) (Four-jointed protein homolog) Fjx1 Mus musculus (Mouse) TR41172_c5_g1_i5 Q5ZEQ8 FJX1_XIPMA 7.00E-35 GO:0005576 extracellular region IPR009581; IPR024868; Four-jointed box protein 1 (Four-jointed protein homolog) fjx1 Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) TR41173_c0_g1_i1 Q9H0Z9 RBM38_HUMAN 5.00E-54 GO:0070935; GO:0006977; GO:0006978; GO:0008380; GO:0007049; GO:0007050; GO:0030154; GO:0005829; GO:0003730; GO:0003729; GO:0006397; GO:0008285; GO:0000166; GO:0005634; GO:0043484; GO:0010830 "3'-UTR-mediated mRNA stabilization; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; RNA splicing; cell cycle; cell cycle arrest; cell differentiation; cytosol; mRNA 3'-UTR binding; mRNA binding; mRNA processing; negative regulation of cell proliferation; nucleotide binding; nucleus; regulation of RNA splicing; regulation of myotube differentiation" IPR012677; IPR000504; RNA-binding protein 38 (CLL-associated antigen KW-5) (HSRNASEB) (RNA-binding motif protein 38) (RNA-binding region-containing protein 1) (ssDNA-binding protein SEB4) RBM38 RNPC1 SEB4 Homo sapiens (Human) TR41174_c0_g1_i1 Q54YL3 INT11_DICDI 1.00E-07 GO:0005737; GO:0016787; GO:0005634 cytoplasm; hydrolase activity; nucleus IPR001279; IPR022712; IPR011108; Integrator complex subunit 11 homolog (EC 3.1.27.-) ints11 DDB_G0278189 Dictyostelium discoideum (Slime mold) TR41174_c0_g1_i2 Q9NV88 INT9_HUMAN 0 GO:0016787; GO:0032039; GO:0016180 hydrolase activity; integrator complex; snRNA processing IPR001279; IPR022712; IPR027074; Integrator complex subunit 9 (Int9) (Protein related to CPSF subunits of 74 kDa) (RC-74) INTS9 RC74 Homo sapiens (Human) TR41174_c0_g1_i4 Q9LKF9 CPSF2_ARATH 2.00E-14 GO:0003723; GO:0016787; GO:0006379; GO:0005847; GO:0006378; GO:0009506; GO:0035194 Q9FGR0; A9LNK9; Q9C952; Q8GUU3; Q6NLV4; O82312 RNA binding; hydrolase activity; mRNA cleavage; mRNA cleavage and polyadenylation specificity factor complex; mRNA polyadenylation; plasmodesma; posttranscriptional gene silencing by RNA IPR001279; IPR022712; IPR027075; IPR025069; Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (AtCPSF100) (CPSF 100 kDa subunit) (Protein EMBRYO DEFECTIVE 1265) (Protein ENHANCED SILENCING PHENOTYPE 5) CPSF100 EMB1265 ESP5 At5g23880 MRO11.8 Arabidopsis thaliana (Mouse-ear cress) TR41174_c0_g1_i5 Q6CUI5 YSH1_KLULA 4.00E-10 GO:0004519; GO:0006397; GO:0046872; GO:0090305; GO:0005634 endonuclease activity; mRNA processing; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleus IPR001279; IPR022712; IPR021718; IPR011108; Endoribonuclease YSH1 (EC 3.1.27.-) (mRNA 3'-end-processing protein YSH1) YSH1 KLLA0C04598g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR41175_c4_g1_i1 Q9D9V7 F116B_MOUSE 6.00E-82 GO:0017112; GO:0055037 Rab guanyl-nucleotide exchange factor activity; recycling endosome IPR018307; IPR024224; Protein DENND6B (DENN domain-containing protein 6B) Dennd6b Mus musculus (Mouse) TR41176_c1_g4_i1 Q9Z2K9 IDHC_MICME 0 GO:0006103; GO:0051287; GO:0005737; GO:0006097; GO:0004450; GO:0006102; GO:0000287; GO:0006099 2-oxoglutarate metabolic process; NAD binding; cytoplasm; glyoxylate cycle; isocitrate dehydrogenase (NADP+) activity; isocitrate metabolic process; magnesium ion binding; tricarboxylic acid cycle IPR019818; IPR004790; IPR024084; Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) IDH1 IDP2 Microtus mexicanus (Mexican vole) TR41176_c1_g4_i2 Q9Z2K9 IDHC_MICME 0 GO:0006103; GO:0051287; GO:0005737; GO:0006097; GO:0004450; GO:0006102; GO:0000287; GO:0006099 2-oxoglutarate metabolic process; NAD binding; cytoplasm; glyoxylate cycle; isocitrate dehydrogenase (NADP+) activity; isocitrate metabolic process; magnesium ion binding; tricarboxylic acid cycle IPR019818; IPR004790; IPR024084; Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) IDH1 IDP2 Microtus mexicanus (Mexican vole) TR41178_c1_g1_i1 Q8NI36 WDR36_HUMAN 0 GO:0005730; GO:0006364; GO:0030516; GO:0050896; GO:0001895; GO:0032040; GO:0007601 nucleolus; rRNA processing; regulation of axon extension; response to stimulus; retina homeostasis; small-subunit processome; visual perception IPR007319; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 36 (T-cell activation WD repeat-containing protein) (TA-WDRP) WDR36 Homo sapiens (Human) TR41179_c0_g1_i1 P21249 ANT1_ONCVO 1.00E-26 Major antigen (Myosin-like antigen) OVT1 Onchocerca volvulus TR41179_c0_g1_i2 Q8CJ40 CROCC_MOUSE 5.00E-125 GO:0015629; GO:0007049; GO:0030030; GO:0005814; GO:0051297; GO:0035253; GO:0005886; GO:0008104; GO:0005198 actin cytoskeleton; cell cycle; cell projection organization; centriole; centrosome organization; ciliary rootlet; plasma membrane; protein localization; structural molecule activity IPR026733; Rootletin (Ciliary rootlet coiled-coil protein) Crocc Kiaa0445 Mus musculus (Mouse) TR41179_c0_g1_i3 Q8CJ40 CROCC_MOUSE 5.00E-125 GO:0015629; GO:0007049; GO:0030030; GO:0005814; GO:0051297; GO:0035253; GO:0005886; GO:0008104; GO:0005198 actin cytoskeleton; cell cycle; cell projection organization; centriole; centrosome organization; ciliary rootlet; plasma membrane; protein localization; structural molecule activity IPR026733; Rootletin (Ciliary rootlet coiled-coil protein) Crocc Kiaa0445 Mus musculus (Mouse) TR41181_c1_g3_i1 Q9UPI3 FLVC2_HUMAN 5.00E-92 GO:0020037; GO:0015232; GO:0016021; GO:0005886; GO:0055085 heme binding; heme transporter activity; integral to membrane; plasma membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Feline leukemia virus subgroup C receptor-related protein 2 (Calcium-chelate transporter) (CCT) FLVCR2 C14orf58 Homo sapiens (Human) TR41181_c1_g3_i5 Q6P3R2 MFS7B_XENTR 3.00E-15 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR016196; Major facilitator superfamily domain-containing protein 7-b mfsd7-B Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41181_c1_g3_i7 Q9UPI3 FLVC2_HUMAN 2.00E-92 GO:0020037; GO:0015232; GO:0016021; GO:0005886; GO:0055085 heme binding; heme transporter activity; integral to membrane; plasma membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Feline leukemia virus subgroup C receptor-related protein 2 (Calcium-chelate transporter) (CCT) FLVCR2 C14orf58 Homo sapiens (Human) TR41181_c1_g4_i2 Q11073 YT45_CAEEL 6.00E-11 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR016196; Uncharacterized protein B0416.5 B0416.5 Caenorhabditis elegans TR41182_c4_g2_i3 Q9NBX4 RTXE_DROME 3.00E-24 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR41183_c0_g4_i1 B8JMH0 CAF17_DANRE 2.00E-37 GO:0004047; GO:0006546; GO:0006783; GO:0005739 aminomethyltransferase activity; glycine catabolic process; heme biosynthetic process; mitochondrion IPR013977; IPR006222; IPR017703; "Putative transferase CAF17 homolog, mitochondrial (EC 2.1.-.-) (Iron-sulfur cluster assembly factor homolog)" iba57 ch1073-162b20.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR41183_c0_g4_i2 Q6FSH5 CAF17_CANGA 9.00E-12 GO:0005739; GO:0016740 mitochondrion; transferase activity IPR017703; "Putative transferase CAF17, mitochondrial (EC 2.1.-.-)" CAF17 CAGL0H00484g Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) TR41183_c0_g4_i3 Q6FSH5 CAF17_CANGA 2.00E-12 GO:0005739; GO:0016740 mitochondrion; transferase activity IPR017703; "Putative transferase CAF17, mitochondrial (EC 2.1.-.-)" CAF17 CAGL0H00484g Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) TR41183_c0_g4_i4 Q7RYZ1 CAF17_NEUCR 3.00E-21 GO:0004047; GO:0006546; GO:0005739 aminomethyltransferase activity; glycine catabolic process; mitochondrion IPR006222; IPR017703; "Putative transferase caf-17, mitochondrial (EC 2.1.-.-)" caf-17 NCU06424 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR41183_c0_g4_i5 B8JMH0 CAF17_DANRE 2.00E-37 GO:0004047; GO:0006546; GO:0006783; GO:0005739 aminomethyltransferase activity; glycine catabolic process; heme biosynthetic process; mitochondrion IPR013977; IPR006222; IPR017703; "Putative transferase CAF17 homolog, mitochondrial (EC 2.1.-.-) (Iron-sulfur cluster assembly factor homolog)" iba57 ch1073-162b20.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR41185_c0_g1_i1 Q16YG0 CDC42_AEDAE 2.00E-73 GO:0005525; GO:0005912; GO:0005622; GO:0045185; GO:0007275; GO:0005886; GO:0045860; GO:0007264 GTP binding; adherens junction; intracellular; maintenance of protein location; multicellular organismal development; plasma membrane; positive regulation of protein kinase activity; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Cdc42 homolog Cdc42 AAEL008543 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR41185_c0_g1_i2 P0CO78 GEM1_CRYNJ 2.00E-09 GO:0005525; GO:0006184; GO:0003924; GO:0005509; GO:0019725; GO:0016021; GO:0005741; GO:0007264 GTP binding; GTP catabolic process; GTPase activity; calcium ion binding; cellular homeostasis; integral to membrane; mitochondrial outer membrane; small GTPase mediated signal transduction IPR011992; IPR018247; IPR013566; IPR013567; IPR002048; IPR020860; IPR013684; IPR027417; IPR021181; IPR001806; Mitochondrial Rho GTPase 1 (EC 3.6.5.-) (GTPase EF-hand protein of mitochondria 1) GEM1 CNF03990 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR41185_c0_g1_i3 Q16YG0 CDC42_AEDAE 2.00E-73 GO:0005525; GO:0005912; GO:0005622; GO:0045185; GO:0007275; GO:0005886; GO:0045860; GO:0007264 GTP binding; adherens junction; intracellular; maintenance of protein location; multicellular organismal development; plasma membrane; positive regulation of protein kinase activity; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Cdc42 homolog Cdc42 AAEL008543 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR41186_c4_g1_i1 P0C7U4 C3AR_DANRE 5.00E-13 GO:0004982; GO:0006935; GO:0016021; GO:0005886 N-formyl peptide receptor activity; chemotaxis; integral to membrane; plasma membrane IPR000826; IPR000276; IPR017452; C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R) c3ar1 Danio rerio (Zebrafish) (Brachydanio rerio) TR41186_c4_g2_i8 P0C7U4 C3AR_DANRE 2.00E-09 GO:0004982; GO:0006935; GO:0016021; GO:0005886 N-formyl peptide receptor activity; chemotaxis; integral to membrane; plasma membrane IPR000826; IPR000276; IPR017452; C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R) c3ar1 Danio rerio (Zebrafish) (Brachydanio rerio) TR41188_c0_g1_i2 Q32KI9 ARSI_MOUSE 5.00E-102 GO:0005783; GO:0005576; GO:0046872; GO:0008484 endoplasmic reticulum; extracellular region; metal ion binding; sulfuric ester hydrolase activity IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase I (ASI) (EC 3.1.6.-) Arsi Mus musculus (Mouse) TR41188_c0_g1_i3 Q32KI9 ARSI_MOUSE 3.00E-103 GO:0005783; GO:0005576; GO:0046872; GO:0008484 endoplasmic reticulum; extracellular region; metal ion binding; sulfuric ester hydrolase activity IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase I (ASI) (EC 3.1.6.-) Arsi Mus musculus (Mouse) TR41188_c0_g1_i5 Q3TYD4 ARSG_MOUSE 8.00E-19 GO:0004065; GO:0005783; GO:0005615; GO:0005764; GO:0046872; GO:0006790 arylsulfatase activity; endoplasmic reticulum; extracellular space; lysosome; metal ion binding; sulfur compound metabolic process IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase G (ASG) (EC 3.1.6.-) Arsg Kiaa1001 Mus musculus (Mouse) TR41188_c0_g1_i6 P15289 ARSA_HUMAN 2.00E-23 GO:0004065; GO:0007339; GO:0005509; GO:0004098; GO:0005788; GO:0006687; GO:0016021; GO:0043202; GO:0005886; GO:0043687; GO:0044281 arylsulfatase activity; binding of sperm to zona pellucida; calcium ion binding; cerebroside-sulfatase activity; endoplasmic reticulum lumen; glycosphingolipid metabolic process; integral to membrane; lysosomal lumen; plasma membrane; post-translational protein modification; small molecule metabolic process IPR017849; IPR017850; IPR000917; IPR024607; Arylsulfatase A (ASA) (EC 3.1.6.8) (Cerebroside-sulfatase) [Cleaved into: Arylsulfatase A component B; Arylsulfatase A component C] ARSA Homo sapiens (Human) TR41191_c1_g5_i1 P08548 LIN1_NYCCO 2.00E-13 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR41192_c6_g1_i1 Q9JLC8 SACS_MOUSE 1.00E-116 GO:0005524; GO:0050750; GO:0005739; GO:0090084; GO:0005634 ATP binding; low-density lipoprotein particle receptor binding; mitochondrion; negative regulation of inclusion body assembly; nucleus IPR001623; IPR003594; IPR007842; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) TR41192_c6_g1_i3 Q9NZJ4 SACS_HUMAN 2.00E-33 GO:0005524; GO:0030424; GO:0070852; GO:0008219; GO:0051087; GO:0030425; GO:0005739; GO:0090084; GO:0005634; GO:0006457 ATP binding; axon; cell body fiber; cell death; chaperone binding; dendrite; mitochondrion; negative regulation of inclusion body assembly; nucleus; protein folding IPR001623; IPR003594; IPR007842; IPR000626; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) TR41194_c0_g1_i1 Q6PFK1 ZN598_DANRE 1.00E-82 GO:0008270 zinc ion binding IPR007087; IPR015880; IPR001841; IPR013083; Zinc finger protein 598 znf598 zfp598 Danio rerio (Zebrafish) (Brachydanio rerio) TR41194_c0_g1_i3 Q6PFK1 ZN598_DANRE 5.00E-82 GO:0008270 zinc ion binding IPR007087; IPR015880; IPR001841; IPR013083; Zinc finger protein 598 znf598 zfp598 Danio rerio (Zebrafish) (Brachydanio rerio) TR41195_c4_g1_i1 Q01484 ANK2_HUMAN 3.00E-22 GO:0051117; GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0007411; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005829; GO:0005887; GO:0014704; GO:0044325; GO:0086046; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307; GO:0070296 P11532-5; P62993 "ATPase binding; M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; axon guidance; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; cytosol; integral to plasma membrane; intercalated disc; ion channel binding; membrane depolarization involved in regulation of SA node cell action potential; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization; sarcoplasmic reticulum calcium ion transport" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) TR41195_c4_g1_i10 G5E8K5 ANK3_MOUSE 7.00E-24 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR41195_c4_g1_i11 A1ZBY1 FEM1B_DROME 2.00E-11 GO:0051438; GO:0004842 regulation of ubiquitin-protein ligase activity; ubiquitin-protein ligase activity IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog B (dFEM-1) Fem-1 CG9025 Drosophila melanogaster (Fruit fly) TR41195_c4_g1_i13 Q3UMR0 ANR27_MOUSE 6.00E-11 GO:0005096; GO:0005769; GO:0045022; GO:0005085; GO:0005764; GO:0043547 Q8QZZ8 GTPase activator activity; early endosome; early endosome to late endosome transport; guanyl-nucleotide exchange factor activity; lysosome; positive regulation of GTPase activity IPR002110; IPR020683; IPR003123; IPR013995; Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein) (VPS9-ankyrin-repeat protein) Ankrd27 Varp Mus musculus (Mouse) TR41195_c4_g1_i14 Q502M6 ANR29_DANRE 1.00E-22 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) TR41195_c4_g1_i2 G5E8K5 ANK3_MOUSE 1.00E-23 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR41195_c4_g1_i4 Q4V869 ACBD6_XENLA 6.00E-17 GO:0005737; GO:0000062; GO:0008289 cytoplasm; fatty-acyl-CoA binding; lipid binding IPR000582; IPR002110; IPR020683; IPR014352; Acyl-CoA-binding domain-containing protein 6 acbd6 Xenopus laevis (African clawed frog) TR41195_c4_g1_i6 Q8C8R3 ANK2_MOUSE 2.00E-21 GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005887; GO:0014704; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086015; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307 "M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; integral to plasma membrane; intercalated disc; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of SA node cell action potential; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Brain ankyrin) Ank2 Mus musculus (Mouse) TR41195_c4_g1_i9 Q8K3X6 ANS4B_MOUSE 2.00E-06 GO:0005886 plasma membrane IPR002110; IPR020683; IPR001660; IPR013761; IPR021129; Ankyrin repeat and SAM domain-containing protein 4B (Harmonin-interacting ankyrin repeat-containing protein) (Harp) Anks4b Harp Mus musculus (Mouse) TR41196_c3_g1_i1 Q80U22 RUSC2_MOUSE 4.00E-27 GO:0005829 cytosol IPR004012; IPR001452; Iporin (Interacting protein of Rab1) (RUN and SH3 domain-containing protein 2) Rusc2 Kiaa0375 Mus musculus (Mouse) TR41198_c1_g2_i1 Q90632 MOT3_CHICK 6.00E-24 GO:0016021; GO:0005886; GO:0015355; GO:0015293 integral to membrane; plasma membrane; secondary active monocarboxylate transmembrane transporter activity; symporter activity IPR011701; IPR020846; IPR016196; IPR004743; Monocarboxylate transporter 3 (MCT 3) (Retinal epithelial membrane protein) (Solute carrier family 16 member 8) SLC16A3 MCT3 REMP Gallus gallus (Chicken) TR41198_c1_g2_i10 Q7RTX9 MOT14_HUMAN 3.00E-29 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR41198_c1_g2_i12 Q7RTX9 MOT14_HUMAN 6.00E-29 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR41198_c1_g2_i2 Q7RTX9 MOT14_HUMAN 6.00E-29 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR41198_c1_g2_i3 Q90632 MOT3_CHICK 1.00E-23 GO:0016021; GO:0005886; GO:0015355; GO:0015293 integral to membrane; plasma membrane; secondary active monocarboxylate transmembrane transporter activity; symporter activity IPR011701; IPR020846; IPR016196; IPR004743; Monocarboxylate transporter 3 (MCT 3) (Retinal epithelial membrane protein) (Solute carrier family 16 member 8) SLC16A3 MCT3 REMP Gallus gallus (Chicken) TR41198_c1_g2_i4 Q7RTX9 MOT14_HUMAN 6.00E-29 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR41198_c1_g2_i5 Q90632 MOT3_CHICK 8.00E-24 GO:0016021; GO:0005886; GO:0015355; GO:0015293 integral to membrane; plasma membrane; secondary active monocarboxylate transmembrane transporter activity; symporter activity IPR011701; IPR020846; IPR016196; IPR004743; Monocarboxylate transporter 3 (MCT 3) (Retinal epithelial membrane protein) (Solute carrier family 16 member 8) SLC16A3 MCT3 REMP Gallus gallus (Chicken) TR41198_c1_g2_i6 Q7RTX9 MOT14_HUMAN 6.00E-29 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR41198_c1_g2_i8 Q7RTX9 MOT14_HUMAN 4.00E-29 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR41199_c4_g3_i1 A0A1F4 EYS_DROME 1.00E-09 GO:0005509; GO:0000902; GO:0005201; GO:0005615; GO:0016021; GO:0005886; GO:0042052; GO:0010378 calcium ion binding; cell morphogenesis; extracellular matrix structural constituent; extracellular space; integral to membrane; plasma membrane; rhabdomere development; temperature compensation of the circadian clock IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Protein eyes shut (Protein spacemaker) eys spam CG33955 Drosophila melanogaster (Fruit fly) TR41199_c4_g3_i2 P07207 NOTCH_DROME 5.00E-10 GO:0005796; GO:0061382; GO:0007219; GO:0048052; GO:0007464; GO:0045466; GO:0045463; GO:0007460; GO:0007015; GO:0005912; GO:0008356; GO:0007298; GO:0005509; GO:0009986; GO:0008407; GO:0003682; GO:0042676; GO:0046667; GO:0005829; GO:0008340; GO:0046843; GO:0007391; GO:0007451; GO:0007398; GO:0035165; GO:0005788; GO:0005768; GO:0061331; GO:0035153; GO:0035214; GO:0007440; GO:0060288; GO:0030718; GO:0030708; GO:0007403; GO:0008347; GO:0035172; GO:0007157; GO:0007446; GO:0016348; GO:0048803; GO:0008587; GO:0007474; GO:0016021; GO:0035171; GO:0046331; GO:0007616; GO:0035170; GO:0007498; GO:0008045; GO:0007521; GO:0046329; GO:0045316; GO:0035157; GO:0050768; GO:0035155; GO:0000122; GO:0007400; GO:0005654; GO:0007314; GO:0030720; GO:0030713; GO:0007422; GO:1900087; GO:0045747; GO:0008284; GO:0045944; GO:0043234; GO:0045468; GO:0042686; GO:0042689; GO:0051489; GO:0040008; GO:0009608; GO:0016330; GO:0007519; GO:0035003; GO:0006351; GO:0004888; GO:0007419; GO:0048190; GO:0007473 Q24279; P10041; P28159 "Golgi lumen; Malpighian tubule tip cell differentiation; Notch signaling pathway; R1/R6 cell differentiation; R3/R4 cell fate commitment; R7 cell differentiation; R8 cell development; R8 cell fate commitment; actin filament organization; adherens junction; asymmetric cell division; border follicle cell migration; calcium ion binding; cell surface; chaeta morphogenesis; chromatin binding; compound eye cone cell fate commitment; compound eye retinal cell programmed cell death; cytosol; determination of adult lifespan; dorsal appendage formation; dorsal closure; dorsal/ventral lineage restriction, imaginal disc; ectoderm development; embryonic crystal cell differentiation; endoplasmic reticulum lumen; endosome; epithelial cell proliferation involved in Malpighian tubule morphogenesis; epithelial cell type specification, open tracheal system; eye-antennal disc development; foregut morphogenesis; formation of a compartment boundary; germ-line stem cell maintenance; germarium-derived female germ-line cyst encapsulation; glial cell fate determination; glial cell migration; hemocyte proliferation; heterophilic cell-cell adhesion; imaginal disc growth; imaginal disc-derived leg joint morphogenesis; imaginal disc-derived male genitalia morphogenesis; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein specification; integral to membrane; lamellocyte differentiation; lateral inhibition; long-term memory; lymph gland crystal cell differentiation; mesoderm development; motor neuron axon guidance; muscle cell fate determination; negative regulation of JNK cascade; negative regulation of compound eye photoreceptor development; negative regulation of fusion cell fate specification; negative regulation of neurogenesis; negative regulation of terminal cell fate specification, open tracheal system; negative regulation of transcription from RNA polymerase II promoter; neuroblast fate determination; nucleoplasm; oocyte anterior/posterior axis specification; oocyte localization involved in germarium-derived egg chamber formation; ovarian follicle cell stalk formation; peripheral nervous system development; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of Notch signaling pathway; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; protein complex; regulation of R8 cell spacing in compound eye; regulation of cardioblast cell fate specification; regulation of crystal cell differentiation; regulation of filopodium assembly; regulation of growth; response to symbiont; second mitotic wave involved in compound eye morphogenesis; skeletal muscle tissue development; subapical complex; transcription, DNA-dependent; transmembrane signaling receptor activity; ventral cord development; wing disc dorsal/ventral pattern formation; wing disc proximal/distal pattern formation" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR000800; IPR010660; IPR011656; Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) TR41199_c4_g3_i8 P07207 NOTCH_DROME 5.00E-10 GO:0005796; GO:0061382; GO:0007219; GO:0048052; GO:0007464; GO:0045466; GO:0045463; GO:0007460; GO:0007015; GO:0005912; GO:0008356; GO:0007298; GO:0005509; GO:0009986; GO:0008407; GO:0003682; GO:0042676; GO:0046667; GO:0005829; GO:0008340; GO:0046843; GO:0007391; GO:0007451; GO:0007398; GO:0035165; GO:0005788; GO:0005768; GO:0061331; GO:0035153; GO:0035214; GO:0007440; GO:0060288; GO:0030718; GO:0030708; GO:0007403; GO:0008347; GO:0035172; GO:0007157; GO:0007446; GO:0016348; GO:0048803; GO:0008587; GO:0007474; GO:0016021; GO:0035171; GO:0046331; GO:0007616; GO:0035170; GO:0007498; GO:0008045; GO:0007521; GO:0046329; GO:0045316; GO:0035157; GO:0050768; GO:0035155; GO:0000122; GO:0007400; GO:0005654; GO:0007314; GO:0030720; GO:0030713; GO:0007422; GO:1900087; GO:0045747; GO:0008284; GO:0045944; GO:0043234; GO:0045468; GO:0042686; GO:0042689; GO:0051489; GO:0040008; GO:0009608; GO:0016330; GO:0007519; GO:0035003; GO:0006351; GO:0004888; GO:0007419; GO:0048190; GO:0007473 Q24279; P10041; P28159 "Golgi lumen; Malpighian tubule tip cell differentiation; Notch signaling pathway; R1/R6 cell differentiation; R3/R4 cell fate commitment; R7 cell differentiation; R8 cell development; R8 cell fate commitment; actin filament organization; adherens junction; asymmetric cell division; border follicle cell migration; calcium ion binding; cell surface; chaeta morphogenesis; chromatin binding; compound eye cone cell fate commitment; compound eye retinal cell programmed cell death; cytosol; determination of adult lifespan; dorsal appendage formation; dorsal closure; dorsal/ventral lineage restriction, imaginal disc; ectoderm development; embryonic crystal cell differentiation; endoplasmic reticulum lumen; endosome; epithelial cell proliferation involved in Malpighian tubule morphogenesis; epithelial cell type specification, open tracheal system; eye-antennal disc development; foregut morphogenesis; formation of a compartment boundary; germ-line stem cell maintenance; germarium-derived female germ-line cyst encapsulation; glial cell fate determination; glial cell migration; hemocyte proliferation; heterophilic cell-cell adhesion; imaginal disc growth; imaginal disc-derived leg joint morphogenesis; imaginal disc-derived male genitalia morphogenesis; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein specification; integral to membrane; lamellocyte differentiation; lateral inhibition; long-term memory; lymph gland crystal cell differentiation; mesoderm development; motor neuron axon guidance; muscle cell fate determination; negative regulation of JNK cascade; negative regulation of compound eye photoreceptor development; negative regulation of fusion cell fate specification; negative regulation of neurogenesis; negative regulation of terminal cell fate specification, open tracheal system; negative regulation of transcription from RNA polymerase II promoter; neuroblast fate determination; nucleoplasm; oocyte anterior/posterior axis specification; oocyte localization involved in germarium-derived egg chamber formation; ovarian follicle cell stalk formation; peripheral nervous system development; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of Notch signaling pathway; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; protein complex; regulation of R8 cell spacing in compound eye; regulation of cardioblast cell fate specification; regulation of crystal cell differentiation; regulation of filopodium assembly; regulation of growth; response to symbiont; second mitotic wave involved in compound eye morphogenesis; skeletal muscle tissue development; subapical complex; transcription, DNA-dependent; transmembrane signaling receptor activity; ventral cord development; wing disc dorsal/ventral pattern formation; wing disc proximal/distal pattern formation" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR000800; IPR010660; IPR011656; Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) TR41202_c0_g3_i2 Q6ER94 BAS1_ORYSJ 1.00E-76 GO:0009507; GO:0042744; GO:0004601; GO:0051920 Q70G58 chloroplast; hydrogen peroxide catabolic process; peroxidase activity; peroxiredoxin activity IPR000866; IPR024706; IPR019479; IPR012336; "2-Cys peroxiredoxin BAS1, chloroplastic (EC 1.11.1.15) (Thiol-specific antioxidant protein)" BAS1 Os02g0537700 LOC_Os02g33450 OSJNBa0014M17.2 P0508B05.23 Oryza sativa subsp. japonica (Rice) TR41202_c0_g3_i4 Q54SE2 PRDXL_DICDI 6.00E-16 GO:0005739; GO:0004601; GO:0051920 mitochondrion; peroxidase activity; peroxiredoxin activity IPR000866; IPR024706; IPR019479; IPR012336; "Peroxiredoxin-like protein DDB_G0282517, mitochondrial (EC 1.11.1.-)" DDB_G0282517 Dictyostelium discoideum (Slime mold) TR41202_c0_g3_i5 Q555L5 PRDX4_DICDI 2.00E-86 GO:0045335; GO:0008379 phagocytic vesicle; thioredoxin peroxidase activity IPR000866; IPR024706; IPR019479; IPR012336; Peroxiredoxin-4 (EC 1.11.1.15) prdx4 DDB_G0274859 Dictyostelium discoideum (Slime mold) TR41202_c0_g3_i6 Q58146 TDXH_METJA 1.00E-27 GO:0016209; GO:0045454; GO:0051920 antioxidant activity; cell redox homeostasis; peroxiredoxin activity IPR000866; IPR024706; IPR019479; IPR022915; IPR012336; Probable peroxiredoxin (EC 1.11.1.15) MJ0736 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR41202_c0_g3_i7 P0CB50 PRDX1_CHICK 5.00E-106 GO:0042744; GO:0005739; GO:0005634; GO:0008379 Q3KTM2 hydrogen peroxide catabolic process; mitochondrion; nucleus; thioredoxin peroxidase activity IPR000866; IPR024706; IPR019479; IPR012336; Peroxiredoxin-1 (EC 1.11.1.15) PRDX1 Gallus gallus (Chicken) TR41203_c0_g1_i5 Q9VQ62 NPC2_DROME 8.00E-27 GO:0045456; GO:0005615; GO:0030882; GO:0001530; GO:0070891; GO:0042834; GO:0061057; GO:0055092; GO:0015918; GO:0008039 Q9VPU1 ecdysteroid biosynthetic process; extracellular space; lipid antigen binding; lipopolysaccharide binding; lipoteichoic acid binding; peptidoglycan binding; peptidoglycan recognition protein signaling pathway; sterol homeostasis; sterol transport; synaptic target recognition IPR014756; IPR003172; Protein NPC2 homolog (Niemann Pick type C2 protein homolog) Npc2a NPC2 CG7291 Drosophila melanogaster (Fruit fly) TR41204_c1_g1_i1 P57513 DCDA_BUCAI 4.00E-15 GO:0008836; GO:0009089; GO:0030170 diaminopimelate decarboxylase activity; lysine biosynthetic process via diaminopimelate; pyridoxal phosphate binding IPR009006; IPR002986; IPR022643; IPR022657; IPR022644; IPR000183; "Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1." Diaminopimelate decarboxylase (DAP decarboxylase) (DAPDC) (EC 4.1.1.20) lysA BU438 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) TR41204_c1_g2_i1 Q6ZG77 DCDA_ORYSJ 1.00E-27 GO:0009507; GO:0008836; GO:0009089 chloroplast; diaminopimelate decarboxylase activity; lysine biosynthetic process via diaminopimelate IPR009006; IPR002986; IPR022643; IPR022657; IPR022644; IPR022653; IPR000183; "Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1." "Probable diaminopimelate decarboxylase, chloroplastic (DAP decarboxylase) (DAPDC) (EC 4.1.1.20)" LYSA Os02g0440000 LOC_Os02g24354 OJ1008_E02.6 OsJ_006351/OsJ_006352 Oryza sativa subsp. japonica (Rice) TR41204_c1_g3_i1 O67262 DCDA_AQUAE 6.00E-28 GO:0008836; GO:0009089; GO:0030170 diaminopimelate decarboxylase activity; lysine biosynthetic process via diaminopimelate; pyridoxal phosphate binding IPR009006; IPR002986; IPR022643; IPR022657; IPR022644; IPR022653; IPR000183; "Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1." Diaminopimelate decarboxylase (DAP decarboxylase) (DAPDC) (EC 4.1.1.20) lysA aq_1208 Aquifex aeolicus (strain VF5) TR41204_c2_g1_i1 Q9PII5 DCDA_CAMJE 3.00E-18 GO:0008836; GO:0009089; GO:0030170 diaminopimelate decarboxylase activity; lysine biosynthetic process via diaminopimelate; pyridoxal phosphate binding IPR009006; IPR002986; IPR022643; IPR022657; IPR022644; IPR000183; "Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1." Diaminopimelate decarboxylase (DAP decarboxylase) (DAPDC) (EC 4.1.1.20) lysA Cj0314 Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) TR41208_c0_g2_i2 A2VDZ3 MEF2A_BOVIN 2.00E-56 GO:0070375; GO:0000977; GO:0001105; GO:0046332; GO:0033613; GO:0006915; GO:0061337; GO:0071277; GO:0003682; GO:0048813; GO:0035035; GO:0042826; GO:0000002; GO:0048311; GO:0000122; GO:0000790; GO:0005634; GO:0045944; GO:0000981; GO:0055005 ERK5 cascade; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription coactivator activity; SMAD binding; activating transcription factor binding; apoptotic process; cardiac conduction; cellular response to calcium ion; chromatin binding; dendrite morphogenesis; histone acetyltransferase binding; histone deacetylase binding; mitochondrial genome maintenance; mitochondrion distribution; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding RNA polymerase II transcription factor activity; ventricular cardiac myofibril assembly IPR022102; IPR002100; Myocyte-specific enhancer factor 2A MEF2A Bos taurus (Bovine) TR41208_c0_g2_i4 A2VDZ3 MEF2A_BOVIN 2.00E-56 GO:0070375; GO:0000977; GO:0001105; GO:0046332; GO:0033613; GO:0006915; GO:0061337; GO:0071277; GO:0003682; GO:0048813; GO:0035035; GO:0042826; GO:0000002; GO:0048311; GO:0000122; GO:0000790; GO:0005634; GO:0045944; GO:0000981; GO:0055005 ERK5 cascade; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription coactivator activity; SMAD binding; activating transcription factor binding; apoptotic process; cardiac conduction; cellular response to calcium ion; chromatin binding; dendrite morphogenesis; histone acetyltransferase binding; histone deacetylase binding; mitochondrial genome maintenance; mitochondrion distribution; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding RNA polymerase II transcription factor activity; ventricular cardiac myofibril assembly IPR022102; IPR002100; Myocyte-specific enhancer factor 2A MEF2A Bos taurus (Bovine) TR41210_c0_g1_i1 Q975U2 PAN_SULTO 1.00E-68 GO:0005524; GO:0006200; GO:0016887; GO:0005737; GO:0010498; GO:0022623; GO:0043335 ATP binding; ATP catabolic process; ATPase activity; cytoplasm; proteasomal protein catabolic process; proteasome-activating nucleotidase complex; protein unfolding IPR005937; IPR003593; IPR003959; IPR003960; IPR023501; IPR027417; Proteasome-activating nucleotidase (PAN) (Proteasomal ATPase) (Proteasome regulatory ATPase) (Proteasome regulatory particle) pan STK_03300 Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) TR41210_c0_g1_i2 Q8JZQ2 AFG32_MOUSE 0 GO:0005524; GO:0007409; GO:0042407; GO:0016265; GO:0016021; GO:0004222; GO:0008053; GO:0005743; GO:0034982; GO:0048747; GO:0042552; GO:0021675; GO:0007528; GO:0017111; GO:0006508; GO:0040014; GO:0060013; GO:0008270 ATP binding; axonogenesis; cristae formation; death; integral to membrane; metalloendopeptidase activity; mitochondrial fusion; mitochondrial inner membrane; mitochondrial protein processing; muscle fiber development; myelination; nerve development; neuromuscular junction development; nucleoside-triphosphatase activity; proteolysis; regulation of multicellular organism growth; righting reflex; zinc ion binding IPR003593; IPR003959; IPR003960; IPR005936; IPR027417; IPR011546; IPR000642; AFG3-like protein 2 (EC 3.4.24.-) Afg3l2 Mus musculus (Mouse) TR41210_c0_g1_i3 Q7TT47 SPG7_RAT 2.00E-87 GO:0005524; GO:0016021; GO:0004222; GO:0031966; GO:0017111; GO:0006508; GO:0008270 ATP binding; integral to membrane; metalloendopeptidase activity; mitochondrial membrane; nucleoside-triphosphatase activity; proteolysis; zinc ion binding IPR003593; IPR003959; IPR027417; IPR011546; IPR000642; Paraplegin (EC 3.4.24.-) Spg7 Rattus norvegicus (Rat) TR41210_c0_g1_i4 Q8JZQ2 AFG32_MOUSE 0 GO:0005524; GO:0007409; GO:0042407; GO:0016265; GO:0016021; GO:0004222; GO:0008053; GO:0005743; GO:0034982; GO:0048747; GO:0042552; GO:0021675; GO:0007528; GO:0017111; GO:0006508; GO:0040014; GO:0060013; GO:0008270 ATP binding; axonogenesis; cristae formation; death; integral to membrane; metalloendopeptidase activity; mitochondrial fusion; mitochondrial inner membrane; mitochondrial protein processing; muscle fiber development; myelination; nerve development; neuromuscular junction development; nucleoside-triphosphatase activity; proteolysis; regulation of multicellular organism growth; righting reflex; zinc ion binding IPR003593; IPR003959; IPR003960; IPR005936; IPR027417; IPR011546; IPR000642; AFG3-like protein 2 (EC 3.4.24.-) Afg3l2 Mus musculus (Mouse) TR41210_c0_g1_i5 A6LD25 FTSH_PARD8 3.00E-162 GO:0005524; GO:0006200; GO:0016887; GO:0016021; GO:0004222; GO:0005886; GO:0030163; GO:0006508; GO:0008270 ATP binding; ATP catabolic process; ATPase activity; integral to membrane; metalloendopeptidase activity; plasma membrane; protein catabolic process; proteolysis; zinc ion binding IPR003593; IPR003959; IPR003960; IPR018247; IPR005936; IPR027417; IPR000642; ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-) ftsH BDI_1854 Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) TR41210_c0_g1_i6 Q20EZ8 FTSHL_OLTVI 3.00E-16 GO:0005524; GO:0031969; GO:0016021; GO:0017111 ATP binding; chloroplast membrane; integral to membrane; nucleoside-triphosphatase activity IPR003593; IPR003959; IPR003960; IPR027417; ATP-dependent zinc metalloprotease FtsH homolog ftsH Oltmannsiellopsis viridis (Marine flagellate) TR41210_c0_g1_i7 Q3B8D5 KATL2_XENLA 1.00E-14 GO:0005524; GO:0005737; GO:0005874; GO:0051013; GO:0008568 ATP binding; cytoplasm; microtubule; microtubule severing; microtubule-severing ATPase activity IPR003593; IPR003959; IPR027497; IPR006594; IPR013720; IPR027417; Katanin p60 ATPase-containing subunit A-like 2 (Katanin p60 subunit A-like 2) (EC 3.6.4.3) (p60 katanin-like 2) katnal2 Xenopus laevis (African clawed frog) TR41212_c1_g1_i2 Q9BWH6 RPAP1_HUMAN 5.00E-29 GO:0003677; GO:0003899; GO:0032774; GO:0005634 DNA binding; DNA-directed RNA polymerase activity; RNA biosynthetic process; nucleus IPR013929; IPR013930; RNA polymerase II-associated protein 1 RPAP1 KIAA1403 Homo sapiens (Human) TR41212_c1_g1_i4 Q80TE0 RPAP1_MOUSE 1.00E-30 GO:0003677; GO:0003899; GO:0032774; GO:0005634 DNA binding; DNA-directed RNA polymerase activity; RNA biosynthetic process; nucleus IPR016024; IPR013929; IPR013930; RNA polymerase II-associated protein 1 Rpap1 Kiaa1403 Mus musculus (Mouse) TR41212_c1_g4_i1 Q9BWH6 RPAP1_HUMAN 6.00E-137 GO:0003677; GO:0003899; GO:0032774; GO:0005634 DNA binding; DNA-directed RNA polymerase activity; RNA biosynthetic process; nucleus IPR013929; IPR013930; RNA polymerase II-associated protein 1 RPAP1 KIAA1403 Homo sapiens (Human) TR41212_c1_g4_i2 O43088 RBA50_SCHPO 1.00E-15 GO:0005665; GO:0005829; GO:0006366 "DNA-directed RNA polymerase II, core complex; cytosol; transcription from RNA polymerase II promoter" IPR013929; IPR013930; RNA polymerase II-associated protein rba50 rba50 SPBC947.13 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41213_c1_g2_i1 Q28034 GLU2B_BOVIN 3.00E-46 GO:0006491; GO:0003723; GO:0005509; GO:0005783; GO:0016787; GO:0001701; GO:0001889; GO:0010977; GO:0006807; GO:0072001 N-glycan processing; RNA binding; calcium ion binding; endoplasmic reticulum; hydrolase activity; in utero embryonic development; liver development; negative regulation of neuron projection development; nitrogen compound metabolic process; renal system development IPR018247; IPR002048; IPR026874; IPR002172; IPR009011; IPR028146; Glycan metabolism; N-glycan metabolism. Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) (Vacuolar system-associated protein 60) (VASAP-60) PRKCSH Bos taurus (Bovine) TR41213_c1_g2_i5 Q9USH8 GLU2B_SCHPO 3.00E-11 GO:0006491; GO:0005783; GO:0004573 N-glycan processing; endoplasmic reticulum; mannosyl-oligosaccharide glucosidase activity IPR026874; IPR002172; IPR009011; IPR028146; Glucosidase 2 subunit beta (Alpha-glucosidase 2 subunit beta) gtb1 gls2-beta SPCC825.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41213_c1_g2_i7 P14314 GLU2B_HUMAN 6.00E-72 GO:0006491; GO:0003723; GO:0005509; GO:0005788; GO:0001701; GO:0045087; GO:0007243; GO:0001889; GO:0010977; GO:0006807; GO:0043687; GO:0018279; GO:0006457; GO:0051291; GO:0072001 N-glycan processing; RNA binding; calcium ion binding; endoplasmic reticulum lumen; in utero embryonic development; innate immune response; intracellular protein kinase cascade; liver development; negative regulation of neuron projection development; nitrogen compound metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine; protein folding; protein heterooligomerization; renal system development IPR018247; IPR002048; IPR026874; IPR002172; IPR009011; IPR028146; Glycan metabolism; N-glycan metabolism. Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) PRKCSH G19P1 Homo sapiens (Human) TR41213_c1_g3_i1 Q28034 GLU2B_BOVIN 1.00E-32 GO:0006491; GO:0003723; GO:0005509; GO:0005783; GO:0016787; GO:0001701; GO:0001889; GO:0010977; GO:0006807; GO:0072001 N-glycan processing; RNA binding; calcium ion binding; endoplasmic reticulum; hydrolase activity; in utero embryonic development; liver development; negative regulation of neuron projection development; nitrogen compound metabolic process; renal system development IPR018247; IPR002048; IPR026874; IPR002172; IPR009011; IPR028146; Glycan metabolism; N-glycan metabolism. Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) (Vacuolar system-associated protein 60) (VASAP-60) PRKCSH Bos taurus (Bovine) TR41213_c1_g3_i2 O08795 GLU2B_MOUSE 7.00E-37 GO:0006491; GO:0003723; GO:0005509; GO:0005783; GO:0001701; GO:0001889; GO:0010977; GO:0006807; GO:0072001 N-glycan processing; RNA binding; calcium ion binding; endoplasmic reticulum; in utero embryonic development; liver development; negative regulation of neuron projection development; nitrogen compound metabolic process; renal system development IPR011992; IPR018247; IPR002048; IPR026874; IPR002172; IPR009011; IPR012913; IPR028146; Glycan metabolism; N-glycan metabolism. Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) Prkcsh Mus musculus (Mouse) TR41214_c0_g1_i1 Q553Y7 GCA_DICDI 2.00E-37 GO:0005525; GO:0006935; GO:0004383; GO:0016021; GO:0035556; GO:0046872; GO:0031037; GO:0031276 GTP binding; chemotaxis; guanylate cyclase activity; integral to membrane; intracellular signal transduction; metal ion binding; myosin II filament disassembly; negative regulation of lateral pseudopodium assembly IPR001054; "Guanylyl cyclase, membrane (EC 4.6.1.2) (DdGCA) (GCA)" gca DDB_G0275009 Dictyostelium discoideum (Slime mold) TR41214_c0_g1_i2 P55202 ANPRB_ANGJA 0 GO:0005524; GO:0005525; GO:0004383; GO:0016021; GO:0035556; GO:0016941; GO:0001503; GO:0004672; GO:0006950 ATP binding; GTP binding; guanylate cyclase activity; integral to membrane; intracellular signal transduction; natriuretic peptide receptor activity; ossification; protein kinase activity; response to stress IPR001054; IPR018297; IPR001828; IPR011009; IPR001170; IPR028082; IPR000719; IPR001245; Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B) npr2 Anguilla japonica (Japanese eel) TR41217_c1_g2_i1 Q9VQX4 PNCB_DROME 5.00E-171 GO:0009435; GO:0005829; GO:0016874; GO:0019358; GO:0004516; GO:0004514; GO:0006979 NAD biosynthetic process; cytosol; ligase activity; nicotinate nucleotide salvage; nicotinate phosphoribosyltransferase activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity; response to oxidative stress IPR007229; IPR006405; IPR002638; Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. Nicotinate phosphoribosyltransferase (NAPRTase) (EC 6.3.4.21) CG3714 Drosophila melanogaster (Fruit fly) TR41218_c0_g1_i1 Q61496 DDX4_MOUSE 4.00E-177 GO:0005524; GO:0008026; GO:0033391; GO:0007141; GO:0007275; GO:0003676; GO:0005634; GO:0048471; GO:0071546; GO:0071547; GO:0032880; GO:0007283 ATP binding; ATP-dependent helicase activity; chromatoid body; male meiosis I; multicellular organismal development; nucleic acid binding; nucleus; perinuclear region of cytoplasm; pi-body; piP-body; regulation of protein localization; spermatogenesis IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX4 (EC 3.6.4.13) (DEAD box protein 4) (Mvh) (Vasa homolog) Ddx4 Vasa Mus musculus (Mouse) TR41219_c4_g1_i3 Q6DFS6 CHM2A_XENTR 5.00E-97 GO:0031902; GO:0015031 late endosome membrane; protein transport IPR005024; Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) chmp2a TNeu078g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41221_c5_g1_i1 Q5F371 SBNO1_CHICK 0 GO:0006355 "regulation of transcription, DNA-dependent" IPR027417; IPR026937; IPR026741; Protein strawberry notch homolog 1 SBNO1 RCJMB04_30k7 Gallus gallus (Chicken) TR41221_c5_g3_i1 Q9Y2G9 SBNO2_HUMAN 2.00E-19 GO:0002281; GO:0045892; GO:0050727; GO:0006351 "macrophage activation involved in immune response; negative regulation of transcription, DNA-dependent; regulation of inflammatory response; transcription, DNA-dependent" IPR027417; IPR026937; IPR026741; Protein strawberry notch homolog 2 SBNO2 KIAA0963 Homo sapiens (Human) TR41221_c5_g3_i2 A3KN83 SBNO1_HUMAN 2.00E-39 GO:0006355 "regulation of transcription, DNA-dependent" IPR027417; IPR026937; IPR026741; Protein strawberry notch homolog 1 (Monocyte protein 3) (MOP-3) SBNO1 MOP3 Homo sapiens (Human) TR41222_c0_g1_i1 P17139 CO4A1_CAEEL 8.00E-173 GO:0005604; GO:0005581; GO:0009790; GO:0030198; GO:0005201; GO:0007517; GO:0002119; GO:0050714 basement membrane; collagen; embryo development; extracellular matrix organization; extracellular matrix structural constituent; muscle organ development; nematode larval development; positive regulation of protein secretion IPR016187; IPR008160; IPR001442; Collagen alpha-1(IV) chain emb-9 clb-2 K04H4.1 Caenorhabditis elegans TR41222_c0_g1_i2 P27393 CO4A2_ASCSU 3.00E-158 GO:0005604; GO:0005581; GO:0005201 basement membrane; collagen; extracellular matrix structural constituent IPR016187; IPR008160; IPR001442; Collagen alpha-2(IV) chain Ascaris suum (Pig roundworm) (Ascaris lumbricoides) TR41222_c0_g1_i3 P17139 CO4A1_CAEEL 5.00E-173 GO:0005604; GO:0005581; GO:0009790; GO:0030198; GO:0005201; GO:0007517; GO:0002119; GO:0050714 basement membrane; collagen; embryo development; extracellular matrix organization; extracellular matrix structural constituent; muscle organ development; nematode larval development; positive regulation of protein secretion IPR016187; IPR008160; IPR001442; Collagen alpha-1(IV) chain emb-9 clb-2 K04H4.1 Caenorhabditis elegans TR41222_c0_g1_i4 P17139 CO4A1_CAEEL 9.00E-173 GO:0005604; GO:0005581; GO:0009790; GO:0030198; GO:0005201; GO:0007517; GO:0002119; GO:0050714 basement membrane; collagen; embryo development; extracellular matrix organization; extracellular matrix structural constituent; muscle organ development; nematode larval development; positive regulation of protein secretion IPR016187; IPR008160; IPR001442; Collagen alpha-1(IV) chain emb-9 clb-2 K04H4.1 Caenorhabditis elegans TR41223_c1_g1_i1 Q97JB8 Y1368_CLOAB 3.00E-16 GO:0005524; GO:0006200; GO:0016887; GO:0006824; GO:0005886 ATP binding; ATP catabolic process; ATPase activity; cobalt ion transport; plasma membrane IPR003593; IPR003439; IPR017871; IPR005876; IPR027417; Putative ABC transporter ATP-binding protein CA_C1368 (EC 3.6.3.-) CA_C1368 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) TR41223_c1_g2_i1 Q767L0 ABCF1_PIG 3.00E-155 GO:0005524; GO:0006200; GO:0016887; GO:0005635; GO:0005654; GO:0042788; GO:0043022; GO:0008494; GO:0006413 ATP binding; ATP catabolic process; ATPase activity; nuclear envelope; nucleoplasm; polysomal ribosome; ribosome binding; translation activator activity; translational initiation IPR003593; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family F member 1 ABCF1 Sus scrofa (Pig) TR41223_c1_g2_i2 P49938 FHUC_BACSU 8.00E-08 GO:0005524; GO:0006200; GO:0006811; GO:0055072; GO:0015623; GO:0005886 ATP binding; ATP catabolic process; ion transport; iron ion homeostasis; iron-chelate-transporting ATPase activity; plasma membrane IPR003593; IPR003439; IPR017871; IPR027417; Iron(3+)-hydroxamate import ATP-binding protein FhuC (EC 3.6.3.34) (Ferric hydroxamate uptake protein C) (Ferrichrome transport ATP-binding protein FhuC) (Iron(III)-hydroxamate import ATP-binding protein FhuC) fhuC BSU33290 Bacillus subtilis (strain 168) TR41223_c1_g2_i4 Q767L0 ABCF1_PIG 2.00E-154 GO:0005524; GO:0006200; GO:0016887; GO:0005635; GO:0005654; GO:0042788; GO:0043022; GO:0008494; GO:0006413 ATP binding; ATP catabolic process; ATPase activity; nuclear envelope; nucleoplasm; polysomal ribosome; ribosome binding; translation activator activity; translational initiation IPR003593; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family F member 1 ABCF1 Sus scrofa (Pig) TR41224_c0_g1_i1 P45219 FTSHL_HAEIN 7.00E-12 GO:0005524; GO:0006200; GO:0016887; GO:0016020; GO:0004222; GO:0030163; GO:0006508; GO:0008270 ATP binding; ATP catabolic process; ATPase activity; membrane; metalloendopeptidase activity; protein catabolic process; proteolysis; zinc ion binding IPR003959; IPR003960; IPR005936; IPR027417; IPR000642; ATP-dependent zinc metalloprotease FtsH homolog HI_1465 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) TR41224_c0_g2_i1 Q5BL07 PEX1_MOUSE 1.00E-152 GO:0005524; GO:0042623; GO:0005829; GO:0008289; GO:0060152; GO:0005634; GO:0005778; GO:0005777; GO:0016558 "ATP binding; ATPase activity, coupled; cytosol; lipid binding; microtubule-based peroxisome localization; nucleus; peroxisomal membrane; peroxisome; protein import into peroxisome matrix" IPR003593; IPR009010; IPR003959; IPR003960; IPR027417; IPR015343; IPR015342; IPR025653; Peroxisome biogenesis factor 1 (Peroxin-1) Pex1 Mus musculus (Mouse) TR41225_c1_g1_i1 O08605 MKNK1_MOUSE 2.00E-121 GO:0005524; GO:0097192; GO:0007243; GO:0018105; GO:0004674; GO:0006417; GO:0009651 ATP binding; extrinsic apoptotic signaling pathway in absence of ligand; intracellular protein kinase cascade; peptidyl-serine phosphorylation; protein serine/threonine kinase activity; regulation of translation; response to salt stress IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) Mknk1 Mnk1 Mus musculus (Mouse) TR41226_c0_g2_i3 Q8K2K6 AGFG1_MOUSE 1.00E-66 GO:0008060; GO:0003677; GO:0001675; GO:0042995; GO:0016023; GO:0045109; GO:0007275; GO:0043025; GO:0005634; GO:0032312; GO:0007289; GO:0006810; GO:0008270 ARF GTPase activator activity; DNA binding; acrosome assembly; cell projection; cytoplasmic membrane-bounded vesicle; intermediate filament organization; multicellular organismal development; neuronal cell body; nucleus; regulation of ARF GTPase activity; spermatid nucleus differentiation; transport; zinc ion binding IPR001164; Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein homolog) (Nucleoporin-like protein RIP) Agfg1 Hrb Rip Mus musculus (Mouse) TR41226_c0_g2_i6 Q8RXE7 AGD14_ARATH 4.00E-23 GO:0008060; GO:0043547; GO:0032312; GO:0008270 ARF GTPase activator activity; positive regulation of GTPase activity; regulation of ARF GTPase activity; zinc ion binding IPR001164; Probable ADP-ribosylation factor GTPase-activating protein AGD14 (ARF GAP AGD14) (Protein ARF-GAP DOMAIN 14) (AtAGD14) (Protein ZIGA4) AGD14 ZIG4 ZIGA4 At1g08680/At1g08690 F22O13.16/F22O13.17 Arabidopsis thaliana (Mouse-ear cress) TR41227_c0_g5_i1 Q9D413 SH2D6_MOUSE 7.00E-08 IPR000980; SH2 domain-containing protein 6 Sh2d6 Mus musculus (Mouse) TR41227_c0_g5_i2 Q13094 LCP2_HUMAN 1.00E-11 GO:0038095; GO:0050852; GO:0050663; GO:0005829; GO:0045087; GO:0045576; GO:0030168; GO:0007169 O15117; O75791; O89100; P62993; Q8IVH8; Q99JP0; P16333; P08487; P19174; Q92783; O75886; P15498 Fc-epsilon receptor signaling pathway; T cell receptor signaling pathway; cytokine secretion; cytosol; innate immune response; mast cell activation; platelet activation; transmembrane receptor protein tyrosine kinase signaling pathway IPR001660; IPR013761; IPR011510; IPR000980; Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) LCP2 Homo sapiens (Human) TR41227_c0_g5_i3 Q9YGC1 BLNK_CHICK 1.00E-15 GO:0042113; GO:0005829; GO:0005886 B cell activation; cytosol; plasma membrane IPR000980; B-cell linker protein (B-cell adapter SH2 domain-containing protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) BLNK BASH Gallus gallus (Chicken) TR41228_c1_g2_i1 Q9Y6L7 TLL2_HUMAN 2.00E-36 GO:0005509; GO:0030154; GO:0030198; GO:0005576; GO:0004222; GO:0007275; GO:0006508; GO:0008270 calcium ion binding; cell differentiation; extracellular matrix organization; extracellular region; metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Tolloid-like protein 2 (EC 3.4.24.-) TLL2 KIAA0932 Homo sapiens (Human) TR41228_c1_g2_i2 Q9JLB4 CUBN_MOUSE 2.00E-45 GO:0005794; GO:0016324; GO:0005903; GO:0005509; GO:0008203; GO:0005905; GO:0031419; GO:0030139; GO:0005783; GO:0005768; GO:0010008; GO:0042953; GO:0005765; GO:0004872; GO:0006898 Golgi apparatus; apical plasma membrane; brush border; calcium ion binding; cholesterol metabolic process; coated pit; cobalamin binding; endocytic vesicle; endoplasmic reticulum; endosome; endosome membrane; lipoprotein transport; lysosomal membrane; receptor activity; receptor-mediated endocytosis IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; Cubilin (Intrinsic factor-cobalamin receptor) Cubn Ifcr Mus musculus (Mouse) TR41229_c0_g1_i2 A2AGT5 CKAP5_MOUSE 0 GO:0050658; GO:0051301; GO:0005737; GO:0005815; GO:0007067; GO:0043234; GO:0000922 RNA transport; cell division; cytoplasm; microtubule organizing center; mitosis; protein complex; spindle pole IPR011989; IPR016024; IPR024395; IPR021133; Cytoskeleton-associated protein 5 Ckap5 Mus musculus (Mouse) TR41229_c0_g1_i3 A2AGT5 CKAP5_MOUSE 0 GO:0050658; GO:0051301; GO:0005737; GO:0005815; GO:0007067; GO:0043234; GO:0000922 RNA transport; cell division; cytoplasm; microtubule organizing center; mitosis; protein complex; spindle pole IPR011989; IPR016024; IPR024395; IPR021133; Cytoskeleton-associated protein 5 Ckap5 Mus musculus (Mouse) TR41229_c0_g1_i4 Q5N749 MOR1_ORYSJ 2.00E-39 GO:0005737; GO:0005874 cytoplasm; microtubule IPR011989; IPR016024; IPR024395; IPR021133; Protein MOR1 (Protein GEM1) (Protein MICROTUBULE ORGANIZATION 1) MOR1 Os01g0816400 LOC_Os01g60040 B1148D12.6-1 OsJ_03864 OSJNBa0085D07.49-1 Oryza sativa subsp. japonica (Rice) TR41229_c0_g1_i5 Q1ZXQ8 MTAA_DICDI 4.00E-26 GO:0007030; GO:0005938; GO:0005813; GO:0051298; GO:0000777; GO:0045502; GO:0030139; GO:0000776; GO:0005874; GO:0008017; GO:0046785; GO:0007067; GO:0000281; GO:0000922 Golgi organization; cell cortex; centrosome; centrosome duplication; condensed chromosome kinetochore; dynein binding; endocytic vesicle; kinetochore; microtubule; microtubule binding; microtubule polymerization; mitosis; mitotic cytokinesis; spindle pole IPR011989; IPR016024; IPR021133; Centrosomal protein 224 (CP224) mtaA DDB_G0268616 Dictyostelium discoideum (Slime mold) TR41229_c0_g1_i6 Q14008 CKAP5_HUMAN 0 GO:0000086; GO:0050658; GO:0051301; GO:0005813; GO:0051297; GO:0005829; GO:0030951; GO:0007067; GO:0007051; GO:0000922 P16333; O75410; O75410-1; O75410-6; Q9Y6A5 G2/M transition of mitotic cell cycle; RNA transport; cell division; centrosome; centrosome organization; cytosol; establishment or maintenance of microtubule cytoskeleton polarity; mitosis; spindle organization; spindle pole IPR011989; IPR016024; IPR024395; IPR000357; IPR021133; Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) CKAP5 KIAA0097 Homo sapiens (Human) TR4123_c0_g1_i1 Q9Y3T6 R3HC1_HUMAN 3.00E-10 GO:0003676; GO:0000166 nucleic acid binding; nucleotide binding IPR012677; IPR001374; R3H and coiled-coil domain-containing protein 1 R3HCC1 Homo sapiens (Human) TR41230_c1_g1_i1 Q8WUA2 PPIL4_HUMAN 4.00E-143 GO:0003723; GO:0000166; GO:0005634; GO:0003755; GO:0006457; GO:0000413 RNA binding; nucleotide binding; nucleus; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR012677; IPR000504; Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4) PPIL4 Homo sapiens (Human) TR41230_c1_g1_i2 Q8WUA2 PPIL4_HUMAN 1.00E-142 GO:0003723; GO:0000166; GO:0005634; GO:0003755; GO:0006457; GO:0000413 RNA binding; nucleotide binding; nucleus; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR012677; IPR000504; Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4) PPIL4 Homo sapiens (Human) TR41230_c1_g1_i3 Q9NI62 CYPE_DICDI 4.00E-39 GO:0005829; GO:0005634; GO:0003755; GO:0006457 P54705 cytosol; nucleus; peptidyl-prolyl cis-trans isomerase activity; protein folding IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase cypE (PPIase cypE) (EC 5.2.1.8) (Cyclophilin cypE) (Rotamase cypE) cypE DDB_G0269216 Dictyostelium discoideum (Slime mold) TR41230_c1_g1_i4 Q9CXG3 PPIL4_MOUSE 3.00E-140 GO:0003723; GO:0000166; GO:0005634; GO:0003755; GO:0006457; GO:0000413 RNA binding; nucleotide binding; nucleus; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR012677; IPR000504; Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4) Ppil4 Mus musculus (Mouse) TR41230_c1_g1_i6 Q5U1W5 U1SBP_RAT 1.00E-12 GO:0003723; GO:0008380; GO:0006397; GO:0000166; GO:0005681 RNA binding; RNA splicing; mRNA processing; nucleotide binding; spliceosomal complex IPR012677; IPR000504; U11/U12 small nuclear ribonucleoprotein 35 kDa protein (U11/U12 snRNP 35 kDa protein) (U1 snRNP-binding protein homolog) Snrnp35 U1snrnpbp Rattus norvegicus (Rat) TR41231_c0_g1_i1 Q4V8R6 E4F1_DANRE 1.00E-68 GO:0003677; GO:0051301; GO:0005737; GO:0016874; GO:0046872; GO:0007067; GO:0005654; GO:0016567; GO:0040008; GO:0006355; GO:0006351 "DNA binding; cell division; cytoplasm; ligase activity; metal ion binding; mitosis; nucleoplasm; protein ubiquitination; regulation of growth; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Protein modification; protein ubiquitination. Transcription factor E4F1 (EC 6.3.2.-) (Putative E3 ubiquitin-protein ligase E4F1) (Transcription factor E4F) e4f1 zgc:114190 Danio rerio (Zebrafish) (Brachydanio rerio) TR41232_c0_g3_i1 O16118 GNAS_HOMAM 0 GO:0007186; GO:0005525; GO:0003924; GO:0046872; GO:0004871 G-protein coupled receptor signaling pathway; GTP binding; GTPase activity; metal ion binding; signal transducer activity IPR000367; IPR001019; IPR011025; IPR027417; Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Homarus americanus (American lobster) TR41233_c0_g3_i1 Q8BH58 TIPRL_MOUSE 5.00E-92 GO:0000077; GO:0005737; GO:0034048 DNA damage checkpoint; cytoplasm; negative regulation of protein phosphatase type 2A activity IPR007303; TIP41-like protein Tiprl Mus musculus (Mouse) TR41233_c0_g3_i5 Q5FW12 TIPRL_XENTR 2.00E-100 GO:0005737 cytoplasm IPR007303; TIP41-like protein tiprl Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41233_c0_g3_i9 Q5FW12 TIPRL_XENTR 1.00E-101 GO:0005737 cytoplasm IPR007303; TIP41-like protein tiprl Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41236_c0_g2_i3 Q8JFY9 ENDUA_XENLA 2.00E-77 GO:0003723; GO:0004521; GO:0030145; GO:0005634; GO:0043144 RNA binding; endoribonuclease activity; manganese ion binding; nucleus; snoRNA processing IPR018998; Poly(U)-specific endoribonuclease-A (EC 3.1.-.-) (Protein endoU-A) (Uridylate-specific endoribonuclease-A) (XendoU-A) endou-a Xenopus laevis (African clawed frog) TR41238_c1_g1_i10 Q7PMT1 EXD_ANOGA 3.00E-146 GO:0003677; GO:0001654; GO:0005634; GO:0007422; GO:0000060; GO:0006357; GO:0043565; GO:0003700; GO:0005667; GO:0006351 "DNA binding; eye development; nucleus; peripheral nervous system development; protein import into nucleus, translocation; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; IPR005542; Homeobox protein extradenticle exd AGAP004696 Anopheles gambiae (African malaria mosquito) TR41238_c1_g1_i3 P41778 PBX1_MOUSE 7.00E-148 GO:0001077; GO:0030325; GO:0009952; GO:0001658; GO:0005737; GO:0035162; GO:0030326; GO:0048706; GO:0045665; GO:0043433; GO:0005634; GO:0009887; GO:0010971; GO:0008284; GO:0009954; GO:0030278; GO:0043565; GO:0007548; GO:0048536; GO:0006694; GO:0048538; GO:0005667 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; adrenal gland development; anterior/posterior pattern specification; branching involved in ureteric bud morphogenesis; cytoplasm; embryonic hemopoiesis; embryonic limb morphogenesis; embryonic skeletal system development; negative regulation of neuron differentiation; negative regulation of sequence-specific DNA binding transcription factor activity; nucleus; organ morphogenesis; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of cell proliferation; proximal/distal pattern formation; regulation of ossification; sequence-specific DNA binding; sex differentiation; spleen development; steroid biosynthetic process; thymus development; transcription factor complex IPR017970; IPR001356; IPR009057; IPR005542; Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) Pbx1 Pbx-1 Mus musculus (Mouse) TR41238_c1_g1_i7 P41778 PBX1_MOUSE 7.00E-148 GO:0001077; GO:0030325; GO:0009952; GO:0001658; GO:0005737; GO:0035162; GO:0030326; GO:0048706; GO:0045665; GO:0043433; GO:0005634; GO:0009887; GO:0010971; GO:0008284; GO:0009954; GO:0030278; GO:0043565; GO:0007548; GO:0048536; GO:0006694; GO:0048538; GO:0005667 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; adrenal gland development; anterior/posterior pattern specification; branching involved in ureteric bud morphogenesis; cytoplasm; embryonic hemopoiesis; embryonic limb morphogenesis; embryonic skeletal system development; negative regulation of neuron differentiation; negative regulation of sequence-specific DNA binding transcription factor activity; nucleus; organ morphogenesis; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of cell proliferation; proximal/distal pattern formation; regulation of ossification; sequence-specific DNA binding; sex differentiation; spleen development; steroid biosynthetic process; thymus development; transcription factor complex IPR017970; IPR001356; IPR009057; IPR005542; Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) Pbx1 Pbx-1 Mus musculus (Mouse) TR41239_c0_g1_i12 Q05116 MP2K1_XENLA 1.00E-70 GO:0005524; GO:0005737; GO:0005634; GO:0018108; GO:0004674; GO:0004713; GO:0005816 ATP binding; cytoplasm; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; spindle pole body IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) map2k1 Xenopus laevis (African clawed frog) TR41239_c0_g1_i6 Q05116 MP2K1_XENLA 1.00E-18 GO:0005524; GO:0005737; GO:0005634; GO:0018108; GO:0004674; GO:0004713; GO:0005816 ATP binding; cytoplasm; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; spindle pole body IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) map2k1 Xenopus laevis (African clawed frog) TR41239_c0_g1_i7 Q92630 DYRK2_HUMAN 6.00E-07 GO:0005524; GO:0005737; GO:0042771; GO:0000287; GO:0030145; GO:0051534; GO:0005634; GO:0045725; GO:0004674; GO:0004712; GO:0004713; GO:0030529; GO:0007224; GO:0043130; GO:0000151 Q9NR20 ATP binding; cytoplasm; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; magnesium ion binding; manganese ion binding; negative regulation of NFAT protein import into nucleus; nucleus; positive regulation of glycogen biosynthetic process; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; ribonucleoprotein complex; smoothened signaling pathway; ubiquitin binding; ubiquitin ligase complex IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) DYRK2 Homo sapiens (Human) TR41239_c0_g1_i8 Q39011 KSG7_ARATH 2.00E-10 GO:0005524; GO:0009742; GO:0009729; GO:0009965; GO:0019048; GO:0009825; GO:0005886; GO:0046827; GO:0046777; GO:0004674; GO:0009733 Q94JM3; Q9LN63 ATP binding; brassinosteroid mediated signaling pathway; detection of brassinosteroid stimulus; leaf morphogenesis; modulation by virus of host morphology or physiology; multidimensional cell growth; plasma membrane; positive regulation of protein export from nucleus; protein autophosphorylation; protein serine/threonine kinase activity; response to auxin stimulus IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Shaggy-related protein kinase eta (EC 2.7.11.1) (ASK-eta) (Protein BRASSINOSTEROID INSENSITIVE 2) (Protein ULTRACURVATA 1) ASK7 BIN2 DWF12 UCU1 At4g18710 F28A21.120 Arabidopsis thaliana (Mouse-ear cress) TR41239_c0_g1_i9 Q55C57 GLKA_DICDI 7.00E-07 GO:0005524; GO:0005977; GO:0018108; GO:0004674; GO:0004713; GO:0050321 ATP binding; glycogen metabolic process; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; tau-protein kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008266; Probable serine/threonine-protein kinase glkA (EC 2.7.11.26) (Glycogen synthase kinase-like kinase A) glkA DDB_G0270218 Dictyostelium discoideum (Slime mold) TR41239_c0_g2_i1 Q05116 MP2K1_XENLA 3.00E-123 GO:0005524; GO:0005737; GO:0005634; GO:0018108; GO:0004674; GO:0004713; GO:0005816 ATP binding; cytoplasm; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; spindle pole body IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) map2k1 Xenopus laevis (African clawed frog) TR41241_c2_g2_i4 B5T255 PGRP1_BOSIN 4.00E-51 GO:0008745; GO:0042742; GO:0050832; GO:0005576; GO:0045087; GO:0031640; GO:0042834; GO:0009253; GO:0008270 N-acetylmuramoyl-L-alanine amidase activity; defense response to bacterium; defense response to fungus; extracellular region; innate immune response; killing of cells of other organism; peptidoglycan binding; peptidoglycan catabolic process; zinc ion binding IPR002502; IPR017331; IPR015510; IPR006619; Peptidoglycan recognition protein 1 PGLYRP1 Bos indicus (Zebu) TR41241_c2_g2_i6 B5T255 PGRP1_BOSIN 2.00E-51 GO:0008745; GO:0042742; GO:0050832; GO:0005576; GO:0045087; GO:0031640; GO:0042834; GO:0009253; GO:0008270 N-acetylmuramoyl-L-alanine amidase activity; defense response to bacterium; defense response to fungus; extracellular region; innate immune response; killing of cells of other organism; peptidoglycan binding; peptidoglycan catabolic process; zinc ion binding IPR002502; IPR017331; IPR015510; IPR006619; Peptidoglycan recognition protein 1 PGLYRP1 Bos indicus (Zebu) TR41241_c3_g1_i1 P51650 SSDH_RAT 0 GO:0051287; GO:0031406; GO:0007417; GO:0009450; GO:0005739; GO:0006105; GO:0004777; GO:0009013 NAD binding; carboxylic acid binding; central nervous system development; gamma-aminobutyric acid catabolic process; mitochondrion; succinate metabolic process; succinate-semialdehyde dehydrogenase (NAD+) activity; succinate-semialdehyde dehydrogenase [NAD(P)+] activity IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR010102; Amino-acid degradation; 4-aminobutanoate degradation. "Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase)" Aldh5a1 Ssadh Rattus norvegicus (Rat) TR41241_c3_g1_i2 Q8RAE5 PROA_THETN 2.00E-07 GO:0055129; GO:0050661; GO:0005737; GO:0004350 L-proline biosynthetic process; NADP binding; cytoplasm; glutamate-5-semialdehyde dehydrogenase activity IPR016161; IPR016163; IPR016162; IPR015590; IPR000965; IPR020593; IPR012134; Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase) (GSA dehydrogenase) proA TTE1278 Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis) TR41241_c3_g1_i4 Q3MSM3 SSDH_HYLLA 0 GO:0007417; GO:0009450; GO:0005739; GO:0051289; GO:0004777; GO:0009013 central nervous system development; gamma-aminobutyric acid catabolic process; mitochondrion; protein homotetramerization; succinate-semialdehyde dehydrogenase (NAD+) activity; succinate-semialdehyde dehydrogenase [NAD(P)+] activity IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR010102; Amino-acid degradation; 4-aminobutanoate degradation. "Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase)" ALDH5A1 Hylobates lar (Common gibbon) (White-handed gibbon) TR41241_c3_g1_i6 Q3MSM3 SSDH_HYLLA 8.00E-84 GO:0007417; GO:0009450; GO:0005739; GO:0051289; GO:0004777; GO:0009013 central nervous system development; gamma-aminobutyric acid catabolic process; mitochondrion; protein homotetramerization; succinate-semialdehyde dehydrogenase (NAD+) activity; succinate-semialdehyde dehydrogenase [NAD(P)+] activity IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR010102; Amino-acid degradation; 4-aminobutanoate degradation. "Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase)" ALDH5A1 Hylobates lar (Common gibbon) (White-handed gibbon) TR41244_c0_g1_i2 Q575S8 CYGB2_DANRE 7.00E-14 GO:0005737; GO:0020037; GO:0005506; GO:0019825; GO:0005344 cytoplasm; heme binding; iron ion binding; oxygen binding; oxygen transporter activity IPR000971; IPR009050; IPR012292; IPR013314; Cytoglobin-2 cygb2 cygb-2 Danio rerio (Zebrafish) (Brachydanio rerio) TR41245_c0_g1_i1 Q5I0D7 PEPD_RAT 0 GO:0004177; GO:0009987; GO:0030574; GO:0016805; GO:0030145; GO:0008237; GO:0006508 aminopeptidase activity; cellular process; collagen catabolic process; dipeptidase activity; manganese ion binding; metallopeptidase activity; proteolysis IPR007865; IPR000994; IPR001131; Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Prolidase) Pepd Rattus norvegicus (Rat) TR41245_c0_g1_i3 Q5I0D7 PEPD_RAT 0 GO:0004177; GO:0009987; GO:0030574; GO:0016805; GO:0030145; GO:0008237; GO:0006508 aminopeptidase activity; cellular process; collagen catabolic process; dipeptidase activity; manganese ion binding; metallopeptidase activity; proteolysis IPR007865; IPR000994; IPR001131; Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Prolidase) Pepd Rattus norvegicus (Rat) TR41245_c0_g1_i6 C6HNY5 AMPP2_AJECH 2.00E-43 GO:0004177; GO:0009987; GO:0030145; GO:0008237; GO:0006508 aminopeptidase activity; cellular process; manganese ion binding; metallopeptidase activity; proteolysis IPR007865; IPR000994; IPR001131; Probable Xaa-Pro aminopeptidase HCDG_07916 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Prolidase) HCDG_07916 Ajellomyces capsulata (strain H143) (Darling's disease fungus) (Histoplasma capsulatum) TR41245_c0_g1_i7 Q5I0D7 PEPD_RAT 0 GO:0004177; GO:0009987; GO:0030574; GO:0016805; GO:0030145; GO:0008237; GO:0006508 aminopeptidase activity; cellular process; collagen catabolic process; dipeptidase activity; manganese ion binding; metallopeptidase activity; proteolysis IPR007865; IPR000994; IPR001131; Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Prolidase) Pepd Rattus norvegicus (Rat) TR41248_c2_g1_i1 Q9CQM0 NICN1_MOUSE 5.00E-55 GO:0005874; GO:0005634 microtubule; nucleus Nicolin-1 (Tubulin polyglutamylase complex subunit 5) (PGs5) (p24) Nicn1 Mus musculus (Mouse) TR41248_c2_g1_i7 Q9CQM0 NICN1_MOUSE 3.00E-54 GO:0005874; GO:0005634 microtubule; nucleus Nicolin-1 (Tubulin polyglutamylase complex subunit 5) (PGs5) (p24) Nicn1 Mus musculus (Mouse) TR41248_c3_g1_i1 Q9W2N0 CAPZA_DROME 3.00E-134 GO:0008290; GO:0071203; GO:0007015; GO:0016324; GO:0051016; GO:0000902; GO:0005869; GO:0007294; GO:0007018; GO:0051490; GO:0006909; GO:0010591; GO:0035220 F-actin capping protein complex; WASH complex; actin filament organization; apical plasma membrane; barbed-end actin filament capping; cell morphogenesis; dynactin complex; germarium-derived oocyte fate determination; microtubule-based movement; negative regulation of filopodium assembly; phagocytosis; regulation of lamellipodium assembly; wing disc development IPR002189; IPR017865; F-actin-capping protein subunit alpha cpa CG10540 Drosophila melanogaster (Fruit fly) TR41249_c0_g1_i1 P50395 GDIB_HUMAN 5.00E-120 GO:0005794; GO:0005093; GO:0005097; GO:0009986; GO:0005829; GO:0016020; GO:0015031; GO:0051056; GO:0007264 P61027; P20338 Golgi apparatus; Rab GDP-dissociation inhibitor activity; Rab GTPase activator activity; cell surface; cytosol; membrane; protein transport; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR018203; IPR000806; Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) GDI2 RABGDIB Homo sapiens (Human) TR41249_c0_g3_i2 Q6Q7J2 GDIB_PIG 1.00E-69 GO:0005096; GO:0005093; GO:0005737; GO:0016020; GO:0043547; GO:0015031 GTPase activator activity; Rab GDP-dissociation inhibitor activity; cytoplasm; membrane; positive regulation of GTPase activity; protein transport IPR018203; IPR000806; Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) GDI2 Sus scrofa (Pig) TR41250_c2_g1_i1 Q503R4 KLH36_DANRE 5.00E-86 GO:0016567 protein ubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 36 klhl36 zgc:110268 Danio rerio (Zebrafish) (Brachydanio rerio) TR41250_c2_g1_i2 Q5F3N5 KLH14_CHICK 6.00E-88 GO:0005829; GO:0005789 cytosol; endoplasmic reticulum membrane IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 14 KLHL14 RCJMB04_11g14 Gallus gallus (Chicken) TR41250_c2_g1_i3 Q80TF4 KLH13_MOUSE 2.00E-117 GO:0031463; GO:0000910; GO:0007067; GO:0016567 Cul3-RING ubiquitin ligase complex; cytokinesis; mitosis; protein ubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 13 (BTB and kelch domain-containing protein 2) Klhl13 Bklhd2 Kiaa1309 Mus musculus (Mouse) TR41250_c2_g1_i4 Q5RGB8 KLH26_DANRE 3.00E-50 IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 26 klhl26 si:ch211-255d18.7 Danio rerio (Zebrafish) (Brachydanio rerio) TR41251_c1_g1_i1 Q96MB7 HARB1_HUMAN 2.00E-31 GO:0005813; GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 centrosome; cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) HARBI1 C11orf77 Homo sapiens (Human) TR41251_c3_g1_i1 O08841 QSOX1_CAVPO 1.00E-11 GO:0045454; GO:0005615; GO:0016971; GO:0030173; GO:0003756 cell redox homeostasis; extracellular space; flavin-linked sulfhydryl oxidase activity; integral to Golgi membrane; protein disulfide isomerase activity IPR017905; IPR012336; IPR013766; Sulfhydryl oxidase 1 (EC 1.8.3.2) (FAD-dependent sulfhydryl oxidase-3) (SOx-3) (Glandular epithelial cells protein 3) (Quiescin Q6) QSOX1 GEC3 QSCN6 SOX3 Cavia porcellus (Guinea pig) TR41251_c8_g1_i1 Q9UA35 S28A3_EPTST 2.00E-40 GO:0016021; GO:0005415 integral to membrane; nucleoside:sodium symporter activity IPR008276; IPR018270; IPR011657; IPR002668; Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT) SLC28A3 CNT3 Eptatretus stoutii (Pacific hagfish) TR41251_c8_g5_i2 B5ZAZ0 ENO_UREU1 3.00E-14 GO:0009986; GO:0005576; GO:0006096; GO:0000287; GO:0004634; GO:0000015 cell surface; extracellular region; glycolysis; magnesium ion binding; phosphopyruvate hydratase activity; phosphopyruvate hydratase complex IPR000941; IPR020810; IPR020809; IPR020811; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5. Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) eno UUR10_0175 Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western) TR41251_c8_g5_i3 A4YHC1 ENO_METS5 3.00E-12 GO:0009986; GO:0005576; GO:0006096; GO:0000287; GO:0004634; GO:0000015 cell surface; extracellular region; glycolysis; magnesium ion binding; phosphopyruvate hydratase activity; phosphopyruvate hydratase complex IPR000941; IPR020810; IPR020809; IPR020811; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5. Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) eno Msed_1668 Metallosphaera sedula (strain ATCC 51363 / DSM 5348) TR41251_c8_g5_i4 Q97ZJ3 ENO_SULSO 1.00E-12 GO:0009986; GO:0005576; GO:0006096; GO:0000287; GO:0004634; GO:0000015 cell surface; extracellular region; glycolysis; magnesium ion binding; phosphopyruvate hydratase activity; phosphopyruvate hydratase complex IPR000941; IPR020810; IPR020809; IPR020811; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5. Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) eno SSO0913 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) TR41251_c9_g1_i1 Q6IUU3 QSOX1_RAT 1.00E-28 GO:0045454; GO:0005615; GO:0016971; GO:0030173; GO:0003756 cell redox homeostasis; extracellular space; flavin-linked sulfhydryl oxidase activity; integral to Golgi membrane; protein disulfide isomerase activity IPR017905; IPR012336; IPR013766; Sulfhydryl oxidase 1 (rQSOX) (rSOx) (EC 1.8.3.2) (FAD-dependent sulfhydryl oxidase-2) (SOx-2) (Quiescin Q6) Qsox1 Qscn6 Sox2 Rattus norvegicus (Rat) TR41252_c0_g1_i14 Q0IIV2 RHBG_XENTR 4.00E-139 GO:0072488; GO:0008519; GO:0016323; GO:0030659; GO:0016021 ammonium transmembrane transport; ammonium transmembrane transporter activity; basolateral plasma membrane; cytoplasmic vesicle membrane; integral to membrane IPR024041; IPR002229; Ammonium transporter Rh type B (Rhesus blood group family type B glycoprotein) (Rh family type B glycoprotein) (Rh type B glycoprotein) rhbg Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41252_c0_g1_i2 Q5U4V1 RHCG_XENLA 6.00E-121 GO:0072488; GO:0008519; GO:0016324; GO:0016021 ammonium transmembrane transport; ammonium transmembrane transporter activity; apical plasma membrane; integral to membrane IPR024041; IPR002229; Ammonium transporter Rh type C (Rhesus blood group family type C glycoprotein) (Rh family type C glycoprotein) (Rh type C glycoprotein) rhcg Xenopus laevis (African clawed frog) TR41252_c0_g1_i3 Q0IIV2 RHBG_XENTR 6.00E-133 GO:0072488; GO:0008519; GO:0016323; GO:0030659; GO:0016021 ammonium transmembrane transport; ammonium transmembrane transporter activity; basolateral plasma membrane; cytoplasmic vesicle membrane; integral to membrane IPR024041; IPR002229; Ammonium transporter Rh type B (Rhesus blood group family type B glycoprotein) (Rh family type B glycoprotein) (Rh type B glycoprotein) rhbg Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41252_c0_g1_i4 Q9QXP0 RHCG_MOUSE 2.00E-115 GO:0051739; GO:0008519; GO:0015696; GO:0016324; GO:0016323; GO:0006873; GO:0005887; GO:0006885; GO:0070634 ammonia transmembrane transporter activity; ammonium transmembrane transporter activity; ammonium transport; apical plasma membrane; basolateral plasma membrane; cellular ion homeostasis; integral to plasma membrane; regulation of pH; transepithelial ammonium transport IPR024041; IPR002229; Ammonium transporter Rh type C (Rhesus blood group family type C glycoprotein) (Rh family type C glycoprotein) (Rh type C glycoprotein) (Rhesus blood group-associated C glycoprotein) (Rhesus-associated C glycoprotein) Rhcg Mus musculus (Mouse) TR41252_c0_g1_i5 Q0IIV2 RHBG_XENTR 5.00E-138 GO:0072488; GO:0008519; GO:0016323; GO:0030659; GO:0016021 ammonium transmembrane transport; ammonium transmembrane transporter activity; basolateral plasma membrane; cytoplasmic vesicle membrane; integral to membrane IPR024041; IPR002229; Ammonium transporter Rh type B (Rhesus blood group family type B glycoprotein) (Rh family type B glycoprotein) (Rh type B glycoprotein) rhbg Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41252_c0_g1_i7 Q20CR3 RHCG_MACMU 2.00E-112 GO:0008519; GO:0030506; GO:0016324; GO:0016323; GO:0006873; GO:0031410; GO:0005887; GO:0070634 ammonium transmembrane transporter activity; ankyrin binding; apical plasma membrane; basolateral plasma membrane; cellular ion homeostasis; cytoplasmic vesicle; integral to plasma membrane; transepithelial ammonium transport IPR024041; IPR002229; Ammonium transporter Rh type C (Rhesus blood group family type C glycoprotein) (Rh family type C glycoprotein) (Rh type C glycoprotein) RHCG Macaca mulatta (Rhesus macaque) TR41252_c0_g1_i8 Q6WRY0 RHCG_XENTR 1.00E-120 GO:0072488; GO:0008519; GO:0016324; GO:0016021 ammonium transmembrane transport; ammonium transmembrane transporter activity; apical plasma membrane; integral to membrane IPR024041; IPR002229; Ammonium transporter Rh type C (Rhesus blood group family type C glycoprotein) (Rh family type C glycoprotein) (Rh type C glycoprotein) rhcg Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41252_c0_g1_i9 Q9QUT0 RHAG_MOUSE 2.00E-120 GO:0051739; GO:0008519; GO:0015670; GO:0006873; GO:0016021; GO:0005886 ammonia transmembrane transporter activity; ammonium transmembrane transporter activity; carbon dioxide transport; cellular ion homeostasis; integral to membrane; plasma membrane IPR024041; IPR002229; Ammonium transporter Rh type A (Erythrocyte membrane glycoprotein Rh50) (Rhesus blood group family type A glycoprotein) (Rh family type A glycoprotein) (Rh type A glycoprotein) (CD antigen CD241) Rhag Rh50 Mus musculus (Mouse) TR41253_c1_g3_i2 P96285 PKS1_MYCTU 3.00E-09 GO:0071770; GO:0006633; GO:0008610; GO:0016491; GO:0031177; GO:0005886; GO:0016747; GO:0008270 "DIM/DIP cell wall layer assembly; fatty acid biosynthetic process; lipid biosynthetic process; oxidoreductase activity; phosphopantetheine binding; plasma membrane; transferase activity, transferring acyl groups other than amino-acyl groups; zinc ion binding" IPR001227; IPR009081; IPR014043; IPR016035; IPR013149; IPR013154; IPR011032; IPR016036; IPR016040; IPR020842; IPR020801; IPR020807; IPR020843; IPR013968; IPR020806; IPR006162; Lipid metabolism; fatty acid biosynthesis. Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks1 pks1 Rv2946c Mycobacterium tuberculosis TR41253_c1_g3_i3 Q59A28 QORL1_BOVIN 5.00E-67 GO:0005829; GO:0016491; GO:0008270 cytosol; oxidoreductase activity; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; Quinone oxidoreductase-like protein 1 (EC 1.-.-.-) (Quinone oxidoreductase homolog 1) (QOH-1) (Zeta-crystallin homolog) CRYZL1 Bos taurus (Bovine) TR41253_c1_g3_i5 Q59A28 QORL1_BOVIN 2.00E-68 GO:0005829; GO:0016491; GO:0008270 cytosol; oxidoreductase activity; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; Quinone oxidoreductase-like protein 1 (EC 1.-.-.-) (Quinone oxidoreductase homolog 1) (QOH-1) (Zeta-crystallin homolog) CRYZL1 Bos taurus (Bovine) TR41253_c1_g3_i6 P96285 PKS1_MYCTU 3.00E-09 GO:0071770; GO:0006633; GO:0008610; GO:0016491; GO:0031177; GO:0005886; GO:0016747; GO:0008270 "DIM/DIP cell wall layer assembly; fatty acid biosynthetic process; lipid biosynthetic process; oxidoreductase activity; phosphopantetheine binding; plasma membrane; transferase activity, transferring acyl groups other than amino-acyl groups; zinc ion binding" IPR001227; IPR009081; IPR014043; IPR016035; IPR013149; IPR013154; IPR011032; IPR016036; IPR016040; IPR020842; IPR020801; IPR020807; IPR020843; IPR013968; IPR020806; IPR006162; Lipid metabolism; fatty acid biosynthesis. Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks1 pks1 Rv2946c Mycobacterium tuberculosis TR41254_c0_g1_i2 A1L0Y2 NEUL4_XENTR 0 GO:0005814 centriole IPR008985; IPR006573; Neuralized-like protein 4 neurl4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41254_c0_g2_i2 Q9BR09 NEUL2_HUMAN 3.00E-07 GO:0030891; GO:0035556; GO:0005927; GO:0016567; GO:0045214 VCB complex; intracellular signal transduction; muscle tendon junction; protein ubiquitination; sarcomere organization IPR006573; IPR001496; Protein modification; protein ubiquitination. Neuralized-like protein 2 NEURL2 C20orf163 Homo sapiens (Human) TR41256_c3_g1_i1 P51397 DAP1_HUMAN 4.00E-10 GO:0006919; GO:0097190; GO:0006914; GO:0034198; GO:0032088; GO:0010507; GO:0045892 "activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic signaling pathway; autophagy; cellular response to amino acid starvation; negative regulation of NF-kappaB transcription factor activity; negative regulation of autophagy; negative regulation of transcription, DNA-dependent" IPR024130; Death-associated protein 1 (DAP-1) DAP DAP1 Homo sapiens (Human) TR41257_c2_g1_i1 Q9H4G4 GAPR1_HUMAN 4.00E-36 GO:0000139; GO:0005576 Golgi membrane; extracellular region IPR001283; IPR018244; IPR014044; Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) GLIPR2 C9orf19 GAPR1 Homo sapiens (Human) TR41257_c2_g1_i2 Q9H4G4 GAPR1_HUMAN 4.00E-35 GO:0000139; GO:0005576 Golgi membrane; extracellular region IPR001283; IPR018244; IPR014044; Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) GLIPR2 C9orf19 GAPR1 Homo sapiens (Human) TR41257_c2_g1_i3 P47033 PRY3_YEAST 4.00E-12 GO:0031225; GO:0005576; GO:0009277; GO:0015918 anchored to membrane; extracellular region; fungal-type cell wall; sterol transport IPR001283; IPR018244; IPR014044; Cell wall protein PRY3 (Pathogen related in Sc 3) PRY3 YJL078C J1027 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41257_c2_g1_i4 P47032 PRY1_YEAST 2.00E-16 GO:0005576; GO:0032934; GO:0015918 extracellular region; sterol binding; sterol transport IPR001283; IPR018244; IPR014044; Protein PRY1 (Pathogen related in Sc 1) PRY1 YJL079C J1022 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41258_c0_g2_i2 Q94F00 IMPL1_ARATH 5.00E-16 GO:0009570; GO:0005829; GO:0006021; GO:0008934; GO:0052832; GO:0052833; GO:0046872; GO:0046854 chloroplast stroma; cytosol; inositol biosynthetic process; inositol monophosphate 1-phosphatase activity; inositol monophosphate 3-phosphatase activity; inositol monophosphate 4-phosphatase activity; metal ion binding; phosphatidylinositol phosphorylation IPR020583; IPR000760; IPR020550; Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2. "Phosphatase IMPL1, chloroplastic (EC 3.1.3.25) (Protein MYO-INOSITOL MONOPHOSPHATASE-LIKE 1)" IMPL1 At1g31190 F28K20.15 Arabidopsis thaliana (Mouse-ear cress) TR41258_c0_g3_i1 P97697 IMPA1_RAT 2.00E-40 GO:0030424; GO:0005737; GO:0006021; GO:0008934; GO:0052832; GO:0052833; GO:0046872; GO:0043025; GO:0006661; GO:0046854; GO:0010226 axon; cytoplasm; inositol biosynthetic process; inositol monophosphate 1-phosphatase activity; inositol monophosphate 3-phosphatase activity; inositol monophosphate 4-phosphatase activity; metal ion binding; neuronal cell body; phosphatidylinositol biosynthetic process; phosphatidylinositol phosphorylation; response to lithium ion IPR020583; IPR020552; IPR000760; IPR020550; Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2. Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1) Impa1 Imp Rattus norvegicus (Rat) TR41258_c0_g3_i2 O55023 IMPA1_MOUSE 4.00E-41 GO:0005737; GO:0006021; GO:0006020; GO:0008934; GO:0052832; GO:0052833; GO:0046855; GO:0046872; GO:0046854; GO:0042803 cytoplasm; inositol biosynthetic process; inositol metabolic process; inositol monophosphate 1-phosphatase activity; inositol monophosphate 3-phosphatase activity; inositol monophosphate 4-phosphatase activity; inositol phosphate dephosphorylation; metal ion binding; phosphatidylinositol phosphorylation; protein homodimerization activity IPR020583; IPR020552; IPR000760; IPR020550; Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2. Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1) Impa1 Mus musculus (Mouse) TR41259_c0_g1_i1 Q9W4E2 NBEA_DROME 0 GO:0042675; GO:0005737; GO:0042462; GO:0016021; GO:0016319; GO:0007528; GO:0043025; GO:0008355; GO:0051018 compound eye cone cell differentiation; cytoplasm; eye photoreceptor cell development; integral to membrane; mushroom body development; neuromuscular junction development; neuronal cell body; olfactory learning; protein kinase A binding IPR016024; IPR000409; IPR008985; IPR013320; IPR010508; IPR023362; IPR015943; IPR001680; IPR017986; Neurobeachin (A-kinase anchor protein 550) (AKAP 550) (Protein rugose) (dAKAP550) rg Akap550 CG6775 Drosophila melanogaster (Fruit fly) TR41260_c1_g3_i1 Q0QLF1 NDMMS_EUBBA 4.00E-11 GO:0051187; GO:0046872; GO:0050138 cofactor catabolic process; metal ion binding; nicotinate dehydrogenase activity IPR008274; Cofactor degradation; nicotinate degradation; 6-hydroxynicotinate from nicotinate: step 1/1. Nicotinate dehydrogenase medium molybdopterin subunit (NDH) (EC 1.17.1.5) (Nicotinic acid hydroxylase medium molybdopterin subunit) (NAH) ndhM Eubacterium barkeri (Clostridium barkeri) TR41260_c2_g1_i10 P10351 XDH_DROME 0 GO:0051537; GO:0008762; GO:0006525; GO:0048072; GO:0008340; GO:0009055; GO:0050660; GO:0006650; GO:0005506; GO:0005875; GO:0043546; GO:0005777; GO:0006206; GO:0006568; GO:0009115; GO:0004854; GO:0004855 "2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; arginine metabolic process; compound eye pigmentation; determination of adult lifespan; electron carrier activity; flavin adenine dinucleotide binding; glycerophospholipid metabolic process; iron ion binding; microtubule associated complex; molybdopterin cofactor binding; peroxisome; pyrimidine nucleobase metabolic process; tryptophan metabolic process; xanthine catabolic process; xanthine dehydrogenase activity; xanthine oxidase activity" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; IPR022407; IPR014307; Xanthine dehydrogenase (XD) (EC 1.17.1.4) (Protein rosy locus) ry XDH CG7642 Drosophila melanogaster (Fruit fly) TR41260_c2_g1_i11 P47990 XDH_CHICK 8.00E-82 GO:0051537; GO:0008762; GO:0005829; GO:0009055; GO:0050660; GO:0005506; GO:0030151; GO:0043546; GO:0005777; GO:0034418; GO:0009115; GO:0004854; GO:0004855 "2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; cytosol; electron carrier activity; flavin adenine dinucleotide binding; iron ion binding; molybdenum ion binding; molybdopterin cofactor binding; peroxisome; urate biosynthetic process; xanthine catabolic process; xanthine dehydrogenase activity; xanthine oxidase activity" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; IPR022407; IPR014309; IPR014307; Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] XDH Gallus gallus (Chicken) TR41260_c2_g1_i2 Q54FB7 XDH_DICDI 3.00E-94 GO:0051537; GO:0008762; GO:0009055; GO:0050660; GO:0005506; GO:0043546; GO:0005777; GO:0009115; GO:0004854 "2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; electron carrier activity; flavin adenine dinucleotide binding; iron ion binding; molybdopterin cofactor binding; peroxisome; xanthine catabolic process; xanthine dehydrogenase activity" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; Xanthine dehydrogenase (XD) (EC 1.17.1.4) xdh DDB_G0291047 Dictyostelium discoideum (Slime mold) TR41260_c2_g1_i3 Q8GUQ8 XDH1_ARATH 3.00E-174 GO:0051537; GO:0008762; GO:0005829; GO:0009055; GO:0050660; GO:0005506; GO:0006145; GO:0000302; GO:0009414; GO:0042554; GO:0004854; GO:0046110 "2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; cytosol; electron carrier activity; flavin adenine dinucleotide binding; iron ion binding; purine nucleobase catabolic process; response to reactive oxygen species; response to water deprivation; superoxide anion generation; xanthine dehydrogenase activity; xanthine metabolic process" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; Xanthine dehydrogenase 1 (AtXDH1) (EC 1.17.1.4) XDH1 At4g34890 T11I11.130 Arabidopsis thaliana (Mouse-ear cress) TR41260_c2_g1_i4 P10351 XDH_DROME 0 GO:0051537; GO:0008762; GO:0006525; GO:0048072; GO:0008340; GO:0009055; GO:0050660; GO:0006650; GO:0005506; GO:0005875; GO:0043546; GO:0005777; GO:0006206; GO:0006568; GO:0009115; GO:0004854; GO:0004855 "2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; arginine metabolic process; compound eye pigmentation; determination of adult lifespan; electron carrier activity; flavin adenine dinucleotide binding; glycerophospholipid metabolic process; iron ion binding; microtubule associated complex; molybdopterin cofactor binding; peroxisome; pyrimidine nucleobase metabolic process; tryptophan metabolic process; xanthine catabolic process; xanthine dehydrogenase activity; xanthine oxidase activity" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; IPR022407; IPR014307; Xanthine dehydrogenase (XD) (EC 1.17.1.4) (Protein rosy locus) ry XDH CG7642 Drosophila melanogaster (Fruit fly) TR41260_c2_g1_i6 P47990 XDH_CHICK 0 GO:0051537; GO:0008762; GO:0005829; GO:0009055; GO:0050660; GO:0005506; GO:0030151; GO:0043546; GO:0005777; GO:0034418; GO:0009115; GO:0004854; GO:0004855 "2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; cytosol; electron carrier activity; flavin adenine dinucleotide binding; iron ion binding; molybdenum ion binding; molybdopterin cofactor binding; peroxisome; urate biosynthetic process; xanthine catabolic process; xanthine dehydrogenase activity; xanthine oxidase activity" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; IPR022407; IPR014309; IPR014307; Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] XDH Gallus gallus (Chicken) TR41260_c2_g1_i9 Q7G193 ALDO1_ARATH 4.00E-158 GO:0051537; GO:0008762; GO:0009688; GO:0009851; GO:0005737; GO:0009055; GO:0050660; GO:0050302; GO:0005506 "2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; abscisic acid biosynthetic process; auxin biosynthetic process; cytoplasm; electron carrier activity; flavin adenine dinucleotide binding; indole-3-acetaldehyde oxidase activity; iron ion binding" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; Indole-3-acetaldehyde oxidase (IAA oxidase) (EC 1.2.3.7) (Aldehyde oxidase 1) (AO-1) (AtAO-1) (AtAO1) AAO1 AO1 At5g20960 F22D1.130 Arabidopsis thaliana (Mouse-ear cress) TR41260_c2_g2_i1 Q0QLF1 NDMMS_EUBBA 8.00E-11 GO:0051187; GO:0046872; GO:0050138 cofactor catabolic process; metal ion binding; nicotinate dehydrogenase activity IPR008274; Cofactor degradation; nicotinate degradation; 6-hydroxynicotinate from nicotinate: step 1/1. Nicotinate dehydrogenase medium molybdopterin subunit (NDH) (EC 1.17.1.5) (Nicotinic acid hydroxylase medium molybdopterin subunit) (NAH) ndhM Eubacterium barkeri (Clostridium barkeri) TR41262_c1_g1_i1 O54927 WSB1_MOUSE 3.00E-06 GO:0005622; GO:0035556; GO:0016567 intracellular; intracellular signal transduction; protein ubiquitination IPR020472; IPR001496; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. WD repeat and SOCS box-containing protein 1 (WSB-1) Wsb1 Mus musculus (Mouse) TR41262_c1_g1_i3 A2CEH0 POC1B_DANRE 1.00E-09 GO:0042384; GO:0060287; GO:0003014 cilium assembly; epithelial cilium movement involved in determination of left/right asymmetry; renal system process IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; POC1 centriolar protein homolog B (WD repeat domain 51B) poc1b tuwd12 wdr51b si:dkey-164B12.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR41262_c1_g2_i1 Q7TMQ7 WDR91_MOUSE 0 IPR015943; IPR001680; IPR017986; WD repeat-containing protein 91 Wdr91 Mus musculus (Mouse) TR41262_c1_g2_i4 B2RYI0 WDR91_RAT 1.00E-163 IPR015943; IPR001680; IPR017986; WD repeat-containing protein 91 Wdr91 Rattus norvegicus (Rat) TR41263_c6_g1_i1 Q9WVB4 SLIT3_MOUSE 6.00E-06 GO:0035385; GO:0061364; GO:0048846; GO:0007411; GO:0005509; GO:0032870; GO:0005615; GO:0050919; GO:0030308; GO:0008285; GO:0070100; GO:0010629; GO:0009887; GO:0005102; GO:0051414 Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; axon guidance; calcium ion binding; cellular response to hormone stimulus; extracellular space; negative chemotaxis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of chemokine-mediated signaling pathway; negative regulation of gene expression; organ morphogenesis; receptor binding; response to cortisol stimulus IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 3 protein (Slit-3) (Slit3) Slit3 Mus musculus (Mouse) TR41264_c0_g1_i1 P19269 AMY1_SCHOC 5.00E-99 GO:0004556; GO:0005509; GO:0016052 alpha-amylase activity; calcium ion binding; carbohydrate catabolic process IPR013777; IPR015340; IPR015902; IPR013780; IPR006047; IPR006589; IPR013781; IPR017853; "Alpha-amylase 1 (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase 1)" AMY1 Schwanniomyces occidentalis (Yeast) (Debaryomyces occidentalis) TR41264_c0_g1_i2 Q10427 YQ29_SCHPO 1.00E-81 GO:0004556; GO:0005509; GO:0009986; GO:0044247; GO:0005829; GO:0046379; GO:0005634 alpha-amylase activity; calcium ion binding; cell surface; cellular polysaccharide catabolic process; cytosol; extracellular polysaccharide metabolic process; nucleus IPR013777; IPR015340; IPR015902; IPR013780; IPR006047; IPR006589; IPR013781; IPR017853; Uncharacterized glycosyl hydrolase C11E10.09c (EC 3.2.1.-) SPCC11E10.09c SPCC188.01c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41264_c0_g1_i3 Q05884 AMY_STRLI 4.00E-19 GO:0004556; GO:0030246; GO:0005975; GO:0005576; GO:0046872 alpha-amylase activity; carbohydrate binding; carbohydrate metabolic process; extracellular region; metal ion binding IPR006048; IPR013784; IPR015902; IPR013780; IPR006047; IPR006589; IPR013781; IPR017853; IPR005323; "Alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase)" amy Streptomyces lividans TR41265_c0_g1_i1 Q10341 CYS2_SCHPO 1.00E-114 GO:0019344; GO:0004414; GO:0009086; GO:0005739 cysteine biosynthetic process; homoserine O-acetyltransferase activity; methionine biosynthetic process; mitochondrion IPR000073; IPR008220; Probable serine-O-acetyltransferase cys2 (EC 2.3.1.-) cys2 SPBC106.17c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41265_c0_g1_i3 Q2RIW8 METX_MOOTA 3.00E-89 GO:0005737; GO:0004414; GO:0009086 cytoplasm; homoserine O-acetyltransferase activity; methionine biosynthetic process IPR000073; IPR008220; Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1. Homoserine O-acetyltransferase (EC 2.3.1.31) (Homoserine O-trans-acetylase) (HTA) (Homoserine transacetylase) metX Moth_1308 Moorella thermoacetica (strain ATCC 39073) TR41265_c0_g1_i4 B9M4M5 METX_GEOSF 3.00E-84 GO:0005737; GO:0004414; GO:0009086 cytoplasm; homoserine O-acetyltransferase activity; methionine biosynthetic process IPR000073; IPR008220; Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1. Homoserine O-acetyltransferase (EC 2.3.1.31) (Homoserine O-trans-acetylase) (HTA) (Homoserine transacetylase) metX Geob_1391 Geobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32) TR41265_c0_g1_i6 P57715 METX_HALSA 3.00E-67 GO:0005737; GO:0004414; GO:0009086 cytoplasm; homoserine O-acetyltransferase activity; methionine biosynthetic process IPR000073; IPR008220; Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1. Homoserine O-acetyltransferase (EC 2.3.1.31) (Homoserine O-trans-acetylase) (HTA) (Homoserine transacetylase) metX VNG_2420G Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) TR41265_c0_g1_i7 Q10341 CYS2_SCHPO 8.00E-116 GO:0019344; GO:0004414; GO:0009086; GO:0005739 cysteine biosynthetic process; homoserine O-acetyltransferase activity; methionine biosynthetic process; mitochondrion IPR000073; IPR008220; Probable serine-O-acetyltransferase cys2 (EC 2.3.1.-) cys2 SPBC106.17c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41265_c0_g1_i8 Q9PAN0 METX_XYLFA 9.00E-96 GO:0005737; GO:0004414; GO:0009086 cytoplasm; homoserine O-acetyltransferase activity; methionine biosynthetic process IPR000073; IPR008220; Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1. Homoserine O-acetyltransferase (EC 2.3.1.31) (Homoserine O-trans-acetylase) (HTA) (Homoserine transacetylase) metX XF_2465 Xylella fastidiosa (strain 9a5c) TR41266_c2_g1_i1 Q9NY47 CA2D2_HUMAN 4.00E-12 GO:0006112; GO:0046872; GO:0048747; GO:0007528; GO:0005886; GO:0046622; GO:0050796; GO:0040014; GO:0060024; GO:0044281; GO:0005245; GO:0005891 energy reserve metabolic process; metal ion binding; muscle fiber development; neuromuscular junction development; plasma membrane; positive regulation of organ growth; regulation of insulin secretion; regulation of multicellular organism growth; rhythmic synaptic transmission; small molecule metabolic process; voltage-gated calcium channel activity; voltage-gated calcium channel complex IPR004010; IPR013680; IPR013608; IPR002035; Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2] CACNA2D2 KIAA0558 Homo sapiens (Human) TR41266_c2_g1_i3 Q5VU97 CAHD1_HUMAN 5.00E-95 GO:0006816; GO:0016021 calcium ion transport; integral to membrane IPR004010; IPR013608; IPR002035; VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) CACHD1 KIAA1573 VWCD1 Homo sapiens (Human) TR41266_c2_g1_i5 Q5VU97 CAHD1_HUMAN 7.00E-96 GO:0006816; GO:0016021 calcium ion transport; integral to membrane IPR004010; IPR013608; IPR002035; VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) CACHD1 KIAA1573 VWCD1 Homo sapiens (Human) TR41267_c1_g2_i2 P46662 MERL_MOUSE 0 GO:0014010; GO:0030036; GO:0005912; GO:0045216; GO:0032154; GO:0030864; GO:0005769; GO:0007398; GO:0019898; GO:0030175; GO:0030027; GO:0070306; GO:0001707; GO:0008156; GO:0043409; GO:0008285; GO:0022408; GO:0006469; GO:0042518; GO:0042524; GO:0005730; GO:0005634; GO:0042475; GO:0048471; GO:0005886; GO:0051496; GO:0035330; GO:0001726 Schwann cell proliferation; actin cytoskeleton organization; adherens junction; cell-cell junction organization; cleavage furrow; cortical actin cytoskeleton; early endosome; ectoderm development; extrinsic to membrane; filopodium; lamellipodium; lens fiber cell differentiation; mesoderm formation; negative regulation of DNA replication; negative regulation of MAPK cascade; negative regulation of cell proliferation; negative regulation of cell-cell adhesion; negative regulation of protein kinase activity; negative regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of tyrosine phosphorylation of Stat5 protein; nucleolus; nucleus; odontogenesis of dentin-containing tooth; perinuclear region of cytoplasm; plasma membrane; positive regulation of stress fiber assembly; regulation of hippo signaling cascade; ruffle IPR019749; IPR019750; IPR015788; IPR011174; IPR011259; IPR000798; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR008954; IPR011993; Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) Nf2 Nf-2 Mus musculus (Mouse) TR41268_c1_g2_i1 Q9JLJ0 LITAF_MOUSE 3.00E-08 GO:0005794; GO:0050699; GO:0006915; GO:0071222; GO:0005765; GO:0042347; GO:0005886; GO:0043123; GO:0001817; GO:0006355; GO:0004871; GO:0006351 P46935 "Golgi apparatus; WW domain binding; apoptotic process; cellular response to lipopolysaccharide; lysosomal membrane; negative regulation of NF-kappaB import into nucleus; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of cytokine production; regulation of transcription, DNA-dependent; signal transducer activity; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Estrogen-enhanced transcript protein) (mEET) (LITAF-like protein) (NEDD4 WW domain-binding protein 3) Litaf N4wbp3 Tbx1 Mus musculus (Mouse) TR41271_c1_g1_i1 Q9VUY8 STRUM_DROME 0 GO:0071203 WASH complex IPR019393; WASH complex subunit strumpellin homolog CG12272 Drosophila melanogaster (Fruit fly) TR41271_c1_g1_i2 Q5R5P0 STRUM_PONAB 0 GO:0071203 WASH complex IPR019393; WASH complex subunit strumpellin Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41271_c1_g2_i3 Q7ZVM1 STRUM_DANRE 8.00E-100 GO:0071203; GO:0007409; GO:0060047 WASH complex; axonogenesis; heart contraction IPR019393; WASH complex subunit strumpellin zgc:55908 Danio rerio (Zebrafish) (Brachydanio rerio) TR41272_c3_g1_i2 A6RAY2 S2538_AJECN 3.00E-26 GO:0016021; GO:0005743; GO:0006810 integral to membrane; mitochondrial inner membrane; transport IPR018108; IPR023395; Solute carrier family 25 member 38 homolog HCAG_06120 Ajellomyces capsulata (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum) TR41272_c3_g1_i3 P0CAT2 S238B_DANRE 9.00E-79 GO:0030218; GO:0016021; GO:0005743; GO:0055085 erythrocyte differentiation; integral to membrane; mitochondrial inner membrane; transmembrane transport IPR002067; IPR018108; IPR023395; Solute carrier family 25 member 38-B slc25a38b Danio rerio (Zebrafish) (Brachydanio rerio) TR41272_c3_g1_i4 Q08CI8 S238A_DANRE 6.00E-82 GO:0030218; GO:0020027; GO:0016021; GO:0005743; GO:0055085 erythrocyte differentiation; hemoglobin metabolic process; integral to membrane; mitochondrial inner membrane; transmembrane transport IPR002067; IPR018108; IPR023395; Solute carrier family 25 member 38-A slc25a38a zgc:153036 Danio rerio (Zebrafish) (Brachydanio rerio) TR41272_c3_g1_i5 Q08CI8 S238A_DANRE 8.00E-80 GO:0030218; GO:0020027; GO:0016021; GO:0005743; GO:0055085 erythrocyte differentiation; hemoglobin metabolic process; integral to membrane; mitochondrial inner membrane; transmembrane transport IPR002067; IPR018108; IPR023395; Solute carrier family 25 member 38-A slc25a38a zgc:153036 Danio rerio (Zebrafish) (Brachydanio rerio) TR41273_c1_g3_i2 P50752 TNNT2_MOUSE 3.00E-06 GO:0003779; GO:0055009; GO:0030049; GO:0032780; GO:0032781; GO:0008016; GO:0006937; GO:0051592; GO:0045214; GO:0005200; GO:0005523; GO:0030172; GO:0031013; GO:0005861; GO:0055010 actin binding; atrial cardiac muscle tissue morphogenesis; muscle filament sliding; negative regulation of ATPase activity; positive regulation of ATPase activity; regulation of heart contraction; regulation of muscle contraction; response to calcium ion; sarcomere organization; structural constituent of cytoskeleton; tropomyosin binding; troponin C binding; troponin I binding; troponin complex; ventricular cardiac muscle tissue morphogenesis IPR027707; IPR001978; "Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT)" Tnnt2 Mus musculus (Mouse) TR41273_c1_g3_i3 Q9XZ71 TNNT_PERAM 9.00E-14 GO:0006937; GO:0005861 regulation of muscle contraction; troponin complex IPR027707; IPR001978; Troponin T (TnT) TNT Periplaneta americana (American cockroach) (Blatta americana) TR41274_c2_g1_i1 P11369 POL2_MOUSE 4.00E-09 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR013544; IPR005135; IPR000477; Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element-1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] Pol Gm17492 Mus musculus (Mouse) TR41275_c1_g2_i1 P42696 RBM34_HUMAN 4.00E-41 GO:0003723; GO:0005730; GO:0000166 RNA binding; nucleolus; nucleotide binding IPR012677; IPR000504; RNA-binding protein 34 (RNA-binding motif protein 34) RBM34 KIAA0117 Homo sapiens (Human) TR41275_c1_g2_i2 P40561 SGN1_YEAST 1.00E-14 GO:0005737; GO:0016071; GO:0000166; GO:0008143 P32588; P53316 cytoplasm; mRNA metabolic process; nucleotide binding; poly(A) RNA binding IPR012677; IPR000504; RNA-binding protein SGN1 SGN1 RBP29 YIR001C YIB1C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41276_c2_g4_i1 O18920 ANGP1_BOVIN 1.00E-37 GO:0001525; GO:0030154; GO:0005576 angiogenesis; cell differentiation; extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-1 (ANG-1) ANGPT1 ANG1 Bos taurus (Bovine) TR41276_c2_g4_i2 Q9BDY8 ANGP1_PIG 2.00E-39 GO:0001525; GO:0030154; GO:0005576 angiogenesis; cell differentiation; extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-1 (ANG-1) ANGPT1 Sus scrofa (Pig) TR41276_c2_g4_i3 Q60FC1 ANGP1_CANFA 6.00E-38 GO:0001525; GO:0030154; GO:0005576 angiogenesis; cell differentiation; extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-1 (ANG-1) ANGPT1 Canis familiaris (Dog) (Canis lupus familiaris) TR41276_c2_g4_i4 O95841 ANGL1_HUMAN 4.00E-35 GO:0005615; GO:0005102; GO:0007169 extracellular space; receptor binding; transmembrane receptor protein tyrosine kinase signaling pathway IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-related protein 1 (Angiopoietin-3) (ANG-3) (Angiopoietin-like protein 1) ANGPTL1 ANG3 ANGPT3 ARP1 PSEC0154 UNQ162/PRO188 Homo sapiens (Human) TR41276_c2_g4_i5 Q24K15 ANGP4_BOVIN 3.00E-35 GO:0001525; GO:0005576 angiogenesis; extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) TR41276_c2_g4_i6 D8VNS8 FCNV2_CERRY 2.00E-35 GO:0005576 extracellular region IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ryncolin-2 Cerberus rynchops (Dog-faced water snake) TR41276_c2_g4_i7 A2AV25 FBCD1_MOUSE 1.00E-34 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 Fibcd1 Mus musculus (Mouse) TR41276_c2_g4_i8 E2IYB3 FCNV1_VARKO 5.00E-15 GO:0005576 extracellular region IPR008160; IPR014716; IPR002181; Veficolin-1 (Fragment) Varanus komodoensis (Komodo dragon) TR41277_c1_g2_i1 Q9SJA1 UBP19_ARATH 6.00E-08 GO:0008234; GO:0016021; GO:0046872; GO:0004221; GO:0006511 cysteine-type peptidase activity; integral to membrane; metal ion binding; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; IPR002893; Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (AtUBP19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) UBP19 At2g24640 F25P17.6 Arabidopsis thaliana (Mouse-ear cress) TR41277_c1_g2_i2 A4QNN3 UBP30_XENTR 1.00E-85 GO:0008234; GO:0016021; GO:0005741; GO:0004221; GO:0006511 cysteine-type peptidase activity; integral to membrane; mitochondrial outer membrane; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30) usp30 TEgg099b09.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41277_c1_g2_i4 A4QNN3 UBP30_XENTR 9.00E-86 GO:0008234; GO:0016021; GO:0005741; GO:0004221; GO:0006511 cysteine-type peptidase activity; integral to membrane; mitochondrial outer membrane; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30) usp30 TEgg099b09.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41277_c1_g2_i6 Q9SJA1 UBP19_ARATH 8.00E-08 GO:0008234; GO:0016021; GO:0046872; GO:0004221; GO:0006511 cysteine-type peptidase activity; integral to membrane; metal ion binding; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; IPR002893; Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (AtUBP19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) UBP19 At2g24640 F25P17.6 Arabidopsis thaliana (Mouse-ear cress) TR41278_c0_g1_i1 P16157 ANK1_HUMAN 2.00E-41 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR41279_c0_g4_i1 Q9NS39 RED2_HUMAN 7.00E-11 GO:0004000; GO:0003725; GO:0006397; GO:0046872; GO:0005739; GO:0005634; GO:0003727 adenosine deaminase activity; double-stranded RNA binding; mRNA processing; metal ion binding; mitochondrion; nucleus; single-stranded RNA binding IPR002466; IPR014720; Double-stranded RNA-specific editase B2 (EC 3.5.-.-) (RNA-dependent adenosine deaminase 3) (RNA-editing deaminase 2) (RNA-editing enzyme 2) (dsRNA adenosine deaminase B2) ADARB2 ADAR3 RED2 Homo sapiens (Human) TR4128_c0_g1_i1 O76840 PPN1_CAEEL 2.00E-08 GO:0005604; GO:0000902; GO:0009792; GO:0048598; GO:0004222; GO:0032504; GO:0002119; GO:0004867; GO:0008270 basement membrane; cell morphogenesis; embryo development ending in birth or egg hatching; embryonic morphogenesis; metalloendopeptidase activity; multicellular organism reproduction; nematode larval development; serine-type endopeptidase inhibitor activity; zinc ion binding IPR010294; IPR007110; IPR013783; IPR003598; IPR013273; IPR010909; IPR002223; IPR020901; IPR000884; Papilin (Abnormal cell migration protein 6) mig-6 ppn-1 C37C3.6 Caenorhabditis elegans TR41281_c2_g1_i3 Q6ING9 PPM1K_XENLA 1.00E-102 GO:0046872; GO:0005759; GO:0006470; GO:0004722 metal ion binding; mitochondrial matrix; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; "Protein phosphatase 1K, mitochondrial (EC 3.1.3.16) (Protein phosphatase 2C isoform kappa) (PP2C-kappa)" ppm1k Xenopus laevis (African clawed frog) TR41281_c2_g1_i5 Q6ING9 PPM1K_XENLA 2.00E-84 GO:0046872; GO:0005759; GO:0006470; GO:0004722 metal ion binding; mitochondrial matrix; protein dephosphorylation; protein serine/threonine phosphatase activity IPR001932; IPR000222; IPR015655; "Protein phosphatase 1K, mitochondrial (EC 3.1.3.16) (Protein phosphatase 2C isoform kappa) (PP2C-kappa)" ppm1k Xenopus laevis (African clawed frog) TR41282_c1_g1_i1 Q7SZP9 APJA_DANRE 3.00E-06 GO:0004945; GO:0048738; GO:0042074; GO:0055113; GO:0016021 angiotensin type II receptor activity; cardiac muscle tissue development; cell migration involved in gastrulation; epiboly involved in gastrulation with mouth forming second; integral to membrane IPR000248; IPR000276; IPR017452; Apelin receptor A (Angiotensin II receptor-like 1a) (Angiotensin receptor-like 1a) (G-protein coupled receptor APJ A) aplnra agtrl1 agtrl1a Danio rerio (Zebrafish) (Brachydanio rerio) TR41282_c1_g1_i2 A5A4K9 GHSR_RABIT 1.00E-10 GO:0008154; GO:0008343; GO:0009986; GO:0032869; GO:0046697; GO:0001616; GO:0030252; GO:0016520; GO:0009755; GO:0016021; GO:0045121; GO:0050728; GO:0032691; GO:0045409; GO:0042536; GO:0043005; GO:0005886; GO:0032100; GO:0043568; GO:0040018; GO:0051963; GO:0032094 actin polymerization or depolymerization; adult feeding behavior; cell surface; cellular response to insulin stimulus; decidualization; growth hormone secretagogue receptor activity; growth hormone secretion; growth hormone-releasing hormone receptor activity; hormone-mediated signaling pathway; integral to membrane; membrane raft; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 biosynthetic process; negative regulation of tumor necrosis factor biosynthetic process; neuron projection; plasma membrane; positive regulation of appetite; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; regulation of synapse assembly; response to food IPR003905; IPR000276; IPR017452; Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) GHSR Oryctolagus cuniculus (Rabbit) TR41282_c1_g1_i4 Q9Y5X5 NPFF2_HUMAN 1.00E-14 GO:0004930; GO:0015629; GO:0009582; GO:0005887; GO:0008188; GO:0007218; GO:0043408; GO:0045761; GO:2000479 G-protein coupled receptor activity; actin cytoskeleton; detection of abiotic stimulus; integral to plasma membrane; neuropeptide receptor activity; neuropeptide signaling pathway; regulation of MAPK cascade; regulation of adenylate cyclase activity; regulation of cAMP-dependent protein kinase activity IPR000276; IPR017452; IPR005395; IPR005397; Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) NPFFR2 GPR74 NPFF2 NPGPR Homo sapiens (Human) TR41282_c1_g1_i5 Q9EQD2 NPFF2_RAT 5.00E-15 GO:0015629; GO:0016021; GO:0008188; GO:0007218; GO:0005886; GO:0043408; GO:0045761; GO:2000479 actin cytoskeleton; integral to membrane; neuropeptide receptor activity; neuropeptide signaling pathway; plasma membrane; regulation of MAPK cascade; regulation of adenylate cyclase activity; regulation of cAMP-dependent protein kinase activity IPR000276; IPR017452; IPR005395; IPR005397; Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide G-protein coupled receptor) Npffr2 Gpr74 Npff2 Npgpr Rattus norvegicus (Rat) TR41282_c1_g1_i7 Q9Y5X5 NPFF2_HUMAN 4.00E-15 GO:0004930; GO:0015629; GO:0009582; GO:0005887; GO:0008188; GO:0007218; GO:0043408; GO:0045761; GO:2000479 G-protein coupled receptor activity; actin cytoskeleton; detection of abiotic stimulus; integral to plasma membrane; neuropeptide receptor activity; neuropeptide signaling pathway; regulation of MAPK cascade; regulation of adenylate cyclase activity; regulation of cAMP-dependent protein kinase activity IPR000276; IPR017452; IPR005395; IPR005397; Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) NPFFR2 GPR74 NPFF2 NPGPR Homo sapiens (Human) TR41282_c1_g3_i1 P10477 GUNE_CLOTM 2.00E-06 GO:0008810; GO:0030245; GO:0016788; GO:0006629 "cellulase activity; cellulose catabolic process; hydrolase activity, acting on ester bonds; lipid metabolic process" IPR016134; IPR002105; IPR018242; IPR001547; IPR018087; IPR013781; IPR017853; IPR001087; IPR013831; "Endoglucanase E (EC 3.2.1.4) (Cellulase E) (Endo-1,4-beta-glucanase E) (EgE)" celE Clostridium thermocellum TR41284_c1_g1_i1 Q9Z0R4 ITSN1_MOUSE 2.00E-34 GO:0005089; GO:0005509; GO:0030054; GO:0005905; GO:0030139; GO:0006897; GO:0019209; GO:0030027; GO:0043524; GO:0043005; GO:0005543; GO:0005886; GO:0051897; GO:0035023; GO:0007264; GO:0045202 A6X8Z5; Q8K382; Q6P549 Rho guanyl-nucleotide exchange factor activity; calcium ion binding; cell junction; coated pit; endocytic vesicle; endocytosis; kinase activator activity; lamellipodium; negative regulation of neuron apoptotic process; neuron projection; phospholipid binding; plasma membrane; positive regulation of protein kinase B signaling cascade; regulation of Rho protein signal transduction; small GTPase mediated signal transduction; synapse IPR000008; IPR000219; IPR011992; IPR018247; IPR002048; IPR000261; IPR001331; IPR011993; IPR001849; IPR001452; Intersectin-1 (EH and SH3 domains protein 1) Itsn1 Ese1 Itsn Mus musculus (Mouse) TR41284_c2_g1_i2 Q9NZM3 ITSN2_HUMAN 1.00E-32 GO:0005089; GO:0005070; GO:0005509; GO:0005737; GO:0006897; GO:0005543; GO:0035023 Q9WNA9 Rho guanyl-nucleotide exchange factor activity; SH3/SH2 adaptor activity; calcium ion binding; cytoplasm; endocytosis; phospholipid binding; regulation of Rho protein signal transduction IPR000008; IPR000219; IPR011992; IPR018247; IPR002048; IPR000261; IPR027029; IPR000108; IPR011993; IPR001849; IPR011511; IPR001452; Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) ITSN2 KIAA1256 SH3D1B SWAP Homo sapiens (Human) TR41284_c2_g1_i3 Q9Z0R6 ITSN2_MOUSE 3.00E-47 GO:0005089; GO:0005509; GO:0005737; GO:0006897; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; calcium ion binding; cytoplasm; endocytosis; phospholipid binding; regulation of Rho protein signal transduction IPR000008; IPR000219; IPR011992; IPR018247; IPR002048; IPR000261; IPR027029; IPR000108; IPR011993; IPR001849; IPR011511; IPR001452; Intersectin-2 (EH domain and SH3 domain regulator of endocytosis 2) (EH and SH3 domains protein 2) (SH3 domain-containing protein 1B) Itsn2 Ese2 Sh3d1B Mus musculus (Mouse) TR41284_c3_g1_i1 Q9NZM3 ITSN2_HUMAN 4.00E-24 GO:0005089; GO:0005070; GO:0005509; GO:0005737; GO:0006897; GO:0005543; GO:0035023 Q9WNA9 Rho guanyl-nucleotide exchange factor activity; SH3/SH2 adaptor activity; calcium ion binding; cytoplasm; endocytosis; phospholipid binding; regulation of Rho protein signal transduction IPR000008; IPR000219; IPR011992; IPR018247; IPR002048; IPR000261; IPR027029; IPR000108; IPR011993; IPR001849; IPR011511; IPR001452; Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) ITSN2 KIAA1256 SH3D1B SWAP Homo sapiens (Human) TR41284_c4_g1_i2 Q15811 ITSN1_HUMAN 4.00E-52 GO:0005089; GO:0097190; GO:0005509; GO:0030054; GO:0005905; GO:0005829; GO:0030139; GO:0005085; GO:0019209; GO:0030027; GO:0043524; GO:0043005; GO:0048011; GO:0005543; GO:0005886; GO:0043065; GO:0051897; GO:0032947; GO:0035023; GO:0051056; GO:0007264; GO:0045202; GO:0048488 P22681; P60953-1; Q9NRI5; P50570; Q3UQN2; O15357; Q925Q9 Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; calcium ion binding; cell junction; coated pit; cytosol; endocytic vesicle; guanyl-nucleotide exchange factor activity; kinase activator activity; lamellipodium; negative regulation of neuron apoptotic process; neuron projection; neurotrophin TRK receptor signaling pathway; phospholipid binding; plasma membrane; positive regulation of apoptotic process; positive regulation of protein kinase B signaling cascade; protein complex scaffold; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; synapse; synaptic vesicle endocytosis IPR000008; IPR000219; IPR011992; IPR018247; IPR002048; IPR000261; IPR001331; IPR000108; IPR011993; IPR001849; IPR001452; Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) ITSN1 ITSN SH3D1A Homo sapiens (Human) TR41284_c4_g1_i3 P29355 SEM5_CAEEL 4.00E-14 GO:0005070; GO:0016477; GO:0030539; GO:0007517; GO:0002119; GO:0031344; GO:0040028 Q62245 SH3/SH2 adaptor activity; cell migration; male genitalia development; muscle organ development; nematode larval development; regulation of cell projection organization; regulation of vulval development IPR000108; IPR000980; IPR001452; Sex muscle abnormal protein 5 sem-5 C14F5.5 Caenorhabditis elegans TR41285_c0_g2_i1 P37167 ACTP_ACACA 3.00E-22 GO:0015629; GO:0030042; GO:0005737 actin cytoskeleton; actin filament depolymerization; cytoplasm IPR002108; IPR017904; Actophorin Acanthamoeba castellanii (Amoeba) TR41285_c0_g2_i12 P37167 ACTP_ACACA 2.00E-21 GO:0015629; GO:0030042; GO:0005737 actin cytoskeleton; actin filament depolymerization; cytoplasm IPR002108; IPR017904; Actophorin Acanthamoeba castellanii (Amoeba) TR41285_c0_g2_i8 P37167 ACTP_ACACA 1.00E-21 GO:0015629; GO:0030042; GO:0005737 actin cytoskeleton; actin filament depolymerization; cytoplasm IPR002108; IPR017904; Actophorin Acanthamoeba castellanii (Amoeba) TR41289_c3_g1_i1 P54254 ATX1_MOUSE 6.00E-46 GO:0003677; GO:0008344; GO:0005737; GO:0043569; GO:0042326; GO:0045892; GO:0051168; GO:0042405; GO:0016363; GO:0005654; GO:0034046; GO:0008266; GO:0045944; GO:0008022; GO:0043621; GO:0060079; GO:0006351; GO:0008542 Q8CHK4; P51448 "DNA binding; adult locomotory behavior; cytoplasm; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of phosphorylation; negative regulation of transcription, DNA-dependent; nuclear export; nuclear inclusion body; nuclear matrix; nucleoplasm; poly(G) RNA binding; poly(U) RNA binding; positive regulation of transcription from RNA polymerase II promoter; protein C-terminus binding; protein self-association; regulation of excitatory postsynaptic membrane potential; transcription, DNA-dependent; visual learning" IPR013723; IPR003652; IPR020997; Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog) Atxn1 Sca1 Mus musculus (Mouse) TR41289_c3_g1_i3 P54254 ATX1_MOUSE 6.00E-46 GO:0003677; GO:0008344; GO:0005737; GO:0043569; GO:0042326; GO:0045892; GO:0051168; GO:0042405; GO:0016363; GO:0005654; GO:0034046; GO:0008266; GO:0045944; GO:0008022; GO:0043621; GO:0060079; GO:0006351; GO:0008542 Q8CHK4; P51448 "DNA binding; adult locomotory behavior; cytoplasm; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of phosphorylation; negative regulation of transcription, DNA-dependent; nuclear export; nuclear inclusion body; nuclear matrix; nucleoplasm; poly(G) RNA binding; poly(U) RNA binding; positive regulation of transcription from RNA polymerase II promoter; protein C-terminus binding; protein self-association; regulation of excitatory postsynaptic membrane potential; transcription, DNA-dependent; visual learning" IPR013723; IPR003652; IPR020997; Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog) Atxn1 Sca1 Mus musculus (Mouse) TR41290_c4_g2_i2 Q13449 LSAMP_HUMAN 6.00E-12 GO:0031225; GO:0007155; GO:0007399; GO:0005886 Q7Z3B1; Q9P121 anchored to membrane; cell adhesion; nervous system development; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Limbic system-associated membrane protein (LSAMP) (IgLON family member 3) LSAMP IGLON3 LAMP Homo sapiens (Human) TR41290_c4_g3_i3 Q24372 LACH_DROME 8.00E-21 GO:0031225; GO:0061343; GO:0007156; GO:0035160; GO:0016331; GO:0005886; GO:0042803; GO:0035151; GO:0005918; GO:0019991 Q9VGH2 "anchored to membrane; cell adhesion involved in heart morphogenesis; homophilic cell adhesion; maintenance of epithelial integrity, open tracheal system; morphogenesis of embryonic epithelium; plasma membrane; protein homodimerization activity; regulation of tube size, open tracheal system; septate junction; septate junction assembly" IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Lachesin Lac CG12369 Drosophila melanogaster (Fruit fly) TR41291_c0_g1_i1 Q9WU42 NCOR2_MOUSE 1.00E-07 GO:0060509; GO:0021846; GO:0003682; GO:0042593; GO:0003007; GO:0000118; GO:0001701; GO:0045599; GO:0000122; GO:0016604; GO:0043565; GO:0021537; GO:0003714; GO:0006351; GO:0050872 "Type I pneumocyte differentiation; cell proliferation in forebrain; chromatin binding; glucose homeostasis; heart morphogenesis; histone deacetylase complex; in utero embryonic development; negative regulation of fat cell differentiation; negative regulation of transcription from RNA polymerase II promoter; nuclear body; sequence-specific DNA binding; telencephalon development; transcription corepressor activity; transcription, DNA-dependent; white fat cell differentiation" IPR009057; IPR001005; IPR017884; "Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)" Ncor2 Smrt Mus musculus (Mouse) TR41291_c1_g3_i1 Q0GGX2 ZN541_MOUSE 6.00E-06 GO:0003677; GO:0030154; GO:0003682; GO:0046872; GO:0007275; GO:0005634; GO:0006355; GO:0007283; GO:0006351 "DNA binding; cell differentiation; chromatin binding; metal ion binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; spermatogenesis; transcription, DNA-dependent" IPR000949; IPR009057; IPR001005; IPR017884; IPR007087; IPR015880; IPR013087; Zinc finger protein 541 (Spermatogenic cell HDAC-interacting protein 1) Znf541 Ship1 Zfp541 Mus musculus (Mouse) TR41291_c1_g3_i2 Q9Y618 NCOR2_HUMAN 5.00E-87 GO:0003677; GO:0007219; GO:0044255; GO:0003682; GO:0000122; GO:0016604; GO:0005634; GO:0072365; GO:0044281; GO:0003714; GO:0006367; GO:0017053; GO:0007179 P35869; P27540; Q01094; Q13547; Q15156; Q06330; Q13573 DNA binding; Notch signaling pathway; cellular lipid metabolic process; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; nuclear body; nucleus; regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter; small molecule metabolic process; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; transcriptional repressor complex; transforming growth factor beta receptor signaling pathway IPR009057; IPR001005; IPR017884; "Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)" NCOR2 CTG26 Homo sapiens (Human) TR41291_c1_g3_i3 Q4KKX4 NCOR1_XENTR 3.00E-93 GO:0003677; GO:0003682; GO:0016568; GO:0005634; GO:0006355; GO:0006351 "DNA binding; chromatin binding; chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009057; IPR001005; IPR017884; Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) (xN-CoR) ncor1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41292_c2_g1_i1 Q99P50 GHSR_MOUSE 2.00E-07 GO:0008154; GO:0008343; GO:0009986; GO:0032869; GO:0046697; GO:0001616; GO:0030252; GO:0016520; GO:0009755; GO:0016021; GO:0045121; GO:0050728; GO:0046676; GO:0032691; GO:0045409; GO:0042536; GO:0043005; GO:0017046; GO:0005886; GO:0032100; GO:0045923; GO:0043568; GO:0040018; GO:0043134; GO:0051963; GO:0032094 actin polymerization or depolymerization; adult feeding behavior; cell surface; cellular response to insulin stimulus; decidualization; growth hormone secretagogue receptor activity; growth hormone secretion; growth hormone-releasing hormone receptor activity; hormone-mediated signaling pathway; integral to membrane; membrane raft; negative regulation of inflammatory response; negative regulation of insulin secretion; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 biosynthetic process; negative regulation of tumor necrosis factor biosynthetic process; neuron projection; peptide hormone binding; plasma membrane; positive regulation of appetite; positive regulation of fatty acid metabolic process; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; regulation of hindgut contraction; regulation of synapse assembly; response to food IPR003905; IPR000276; IPR017452; Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) Ghsr Mus musculus (Mouse) TR41293_c0_g1_i1 P48764 SL9A3_HUMAN 2.00E-115 GO:0030165; GO:0016324; GO:0031526; GO:0009986; GO:0016021; GO:0006885; GO:0015385 Q6P0Q8 PDZ domain binding; apical plasma membrane; brush border membrane; cell surface; integral to membrane; regulation of pH; sodium:hydrogen antiporter activity IPR006153; IPR018422; IPR018410; IPR004709; Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3) SLC9A3 NHE3 Homo sapiens (Human) TR41293_c0_g1_i3 Q8BLV3 SL9A7_MOUSE 2.00E-20 GO:0005794; GO:0016021; GO:0015386; GO:0055038; GO:0006885; GO:0015385; GO:0005802 Golgi apparatus; integral to membrane; potassium:hydrogen antiporter activity; recycling endosome membrane; regulation of pH; sodium:hydrogen antiporter activity; trans-Golgi network IPR006153; IPR018422; IPR002090; IPR004709; Sodium/hydrogen exchanger 7 (Na(+)/H(+) exchanger 7) (NHE-7) (Solute carrier family 9 member 7) Slc9a7 Nhe7 Mus musculus (Mouse) TR41293_c0_g1_i4 P48764 SL9A3_HUMAN 2.00E-115 GO:0030165; GO:0016324; GO:0031526; GO:0009986; GO:0016021; GO:0006885; GO:0015385 Q6P0Q8 PDZ domain binding; apical plasma membrane; brush border membrane; cell surface; integral to membrane; regulation of pH; sodium:hydrogen antiporter activity IPR006153; IPR018422; IPR018410; IPR004709; Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3) SLC9A3 NHE3 Homo sapiens (Human) TR41293_c0_g2_i1 Q68KI4 NHX1_ARATH 1.00E-07 GO:0000139; GO:0005789; GO:0016021; GO:0048366; GO:0010351; GO:0000325; GO:0005886; GO:0055075; GO:0006885; GO:0090333; GO:0009651; GO:0015385; GO:0005774 Golgi membrane; endoplasmic reticulum membrane; integral to membrane; leaf development; lithium ion transport; plant-type vacuole; plasma membrane; potassium ion homeostasis; regulation of pH; regulation of stomatal closure; response to salt stress; sodium:hydrogen antiporter activity; vacuolar membrane IPR006153; IPR018422; IPR004709; Sodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) NHX1 At5g27150 T21B4.60 Arabidopsis thaliana (Mouse-ear cress) TR41294_c2_g1_i5 P45452 MMP13_HUMAN 2.00E-18 GO:0030282; GO:0005509; GO:0051216; GO:0044267; GO:0030574; GO:0022617; GO:0005615; GO:0004222; GO:0005578; GO:0006508; GO:0008270 bone mineralization; calcium ion binding; cartilage development; cellular protein metabolic process; collagen catabolic process; extracellular matrix disassembly; extracellular space; metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000585; IPR018487; IPR018486; IPR024079; IPR001818; IPR021190; IPR016293; IPR021158; IPR006026; IPR002477; Collagenase 3 (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13) MMP13 Homo sapiens (Human) TR41294_c2_g5_i1 Q11005 MMP11_XENLA 1.00E-34 GO:0005509; GO:0030574; GO:0004222; GO:0005578; GO:0006508; GO:0008270 calcium ion binding; collagen catabolic process; metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000585; IPR018487; IPR018486; IPR024079; IPR001818; IPR021190; IPR016293; IPR021158; IPR006026; Stromelysin-3 (ST3) (EC 3.4.24.-) (Matrix metalloproteinase-11) (MMP-11) mmp11 Xenopus laevis (African clawed frog) TR41295_c0_g1_i1 Q9CSH3 RRP44_MOUSE 0 GO:0000175; GO:0071034; GO:0003723; GO:0005737; GO:0004519; GO:0005085; GO:0000176; GO:0005730; GO:0005654; GO:0016075; GO:0006364 3'-5'-exoribonuclease activity; CUT catabolic process; RNA binding; cytoplasm; endonuclease activity; guanyl-nucleotide exchange factor activity; nuclear exosome (RNase complex); nucleolus; nucleoplasm; rRNA catabolic process; rRNA processing IPR012340; IPR002716; IPR022966; Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44) Dis3 Kiaa1008 Rrp44 Mus musculus (Mouse) TR41297_c1_g1_i1 B8G736 LON_CHLAD 3.00E-118 GO:0005524; GO:0006200; GO:0004176; GO:0033554; GO:0005737; GO:0006515; GO:0043565; GO:0004252 ATP binding; ATP catabolic process; ATP-dependent peptidase activity; cellular response to stress; cytoplasm; misfolded or incompletely synthesized protein catabolic process; sequence-specific DNA binding; serine-type endopeptidase activity IPR003593; IPR003959; IPR027543; IPR004815; IPR027065; IPR027417; IPR008269; IPR003111; IPR015947; IPR020568; IPR014721; Lon protease (EC 3.4.21.53) (ATP-dependent protease La) lon Cagg_1079 Chloroflexus aggregans (strain MD-66 / DSM 9485) TR41297_c1_g1_i2 B8CY71 LON_HALOH 9.00E-77 GO:0005524; GO:0006200; GO:0004176; GO:0033554; GO:0005737; GO:0006515; GO:0043565; GO:0004252 ATP binding; ATP catabolic process; ATP-dependent peptidase activity; cellular response to stress; cytoplasm; misfolded or incompletely synthesized protein catabolic process; sequence-specific DNA binding; serine-type endopeptidase activity IPR003593; IPR003959; IPR027543; IPR004815; IPR027065; IPR027417; IPR008269; IPR003111; IPR008268; IPR015947; IPR020568; IPR014721; Lon protease (EC 3.4.21.53) (ATP-dependent protease La) lon Hore_14910 Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562) TR41297_c1_g1_i3 Q5PQY6 LONP2_DANRE 0 GO:0005524; GO:0004176; GO:0006515; GO:0009295; GO:0005782; GO:0016558; GO:0016485; GO:0043565; GO:0004252 ATP binding; ATP-dependent peptidase activity; misfolded or incompletely synthesized protein catabolic process; nucleoid; peroxisomal matrix; protein import into peroxisome matrix; protein processing; sequence-specific DNA binding; serine-type endopeptidase activity IPR003593; IPR003959; IPR004815; IPR027065; IPR027501; IPR027417; IPR008269; IPR003111; IPR008268; IPR015947; IPR020568; IPR014721; "Lon protease homolog 2, peroxisomal (EC 3.4.21.-)" lonp2 zgc:92557 Danio rerio (Zebrafish) (Brachydanio rerio) TR41297_c1_g1_i5 Q9DBN5 LONP2_MOUSE 0 GO:0005524; GO:0004176; GO:0006515; GO:0009295; GO:0005634; GO:0005782; GO:0016558; GO:0016485; GO:0031998; GO:0014070; GO:0043565; GO:0004252; GO:0006465 ATP binding; ATP-dependent peptidase activity; misfolded or incompletely synthesized protein catabolic process; nucleoid; nucleus; peroxisomal matrix; protein import into peroxisome matrix; protein processing; regulation of fatty acid beta-oxidation; response to organic cyclic compound; sequence-specific DNA binding; serine-type endopeptidase activity; signal peptide processing IPR003593; IPR003959; IPR004815; IPR027065; IPR027501; IPR027417; IPR008269; IPR003111; IPR008268; IPR015947; IPR020568; IPR014721; "Lon protease homolog 2, peroxisomal (EC 3.4.21.-) (Lon protease-like protein 2) (Lon protease 2) (Peroxisomal Lon protease)" Lonp2 Mus musculus (Mouse) TR41298_c2_g2_i1 Q5ZL67 NF2L1_CHICK 4.00E-32 GO:0005789; GO:0016021; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "endoplasmic reticulum membrane; integral to membrane; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; IPR004826; IPR008917; "Nuclear factor erythroid 2-related factor 1 (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1)" NFE2L1 NRF1 RCJMB04_7g14 Gallus gallus (Chicken) TR41298_c2_g2_i3 Q9Y4A8 NF2L3_HUMAN 5.00E-29 GO:0005634; GO:0043565; GO:0003700; GO:0003713; GO:0006366 nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription from RNA polymerase II promoter IPR004827; IPR004826; IPR008917; "Nuclear factor erythroid 2-related factor 3 (NF-E2-related factor 3) (NFE2-related factor 3) (Nuclear factor, erythroid derived 2, like 3)" NFE2L3 NRF3 Homo sapiens (Human) TR41298_c2_g2_i6 Q5ZL67 NF2L1_CHICK 4.00E-32 GO:0005789; GO:0016021; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "endoplasmic reticulum membrane; integral to membrane; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; IPR004826; IPR008917; "Nuclear factor erythroid 2-related factor 1 (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1)" NFE2L1 NRF1 RCJMB04_7g14 Gallus gallus (Chicken) TR41299_c5_g1_i2 Q865K9 MPRB_PIG 2.00E-24 GO:0030154; GO:0016021; GO:0007275; GO:0048477; GO:0005886; GO:0005496 cell differentiation; integral to membrane; multicellular organismal development; oogenesis; plasma membrane; steroid binding IPR004254; Membrane progestin receptor beta (mPR beta) (Progestin and adipoQ receptor family member VIII) PAQR8 MPRB Sus scrofa (Pig) TR41299_c5_g1_i3 Q753H5 IZH1_ASHGO 4.00E-07 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR004254; ADIPOR-like receptor IZH1 IZH1 AFR337W Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR41300_c1_g1_i2 Q13887 KLF5_HUMAN 6.00E-47 GO:0003677; GO:0005794; GO:0001525; GO:0046872; GO:0030033; GO:0005634; GO:0045893; GO:0003700; GO:0035914; GO:0006366 P0CG48 "DNA binding; Golgi apparatus; angiogenesis; metal ion binding; microvillus assembly; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; skeletal muscle cell differentiation; transcription from RNA polymerase II promoter" IPR007087; IPR015880; IPR013087; Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2) KLF5 BTEB2 CKLF IKLF Homo sapiens (Human) TR41300_c1_g1_i4 P10073 ZSC22_HUMAN 2.00E-15 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 22 (Krueppel-related zinc finger protein 2) (Protein HKR2) (Zinc finger protein 50) ZSCAN22 HKR2 ZNF50 Homo sapiens (Human) TR41300_c1_g1_i6 Q13887 KLF5_HUMAN 6.00E-47 GO:0003677; GO:0005794; GO:0001525; GO:0046872; GO:0030033; GO:0005634; GO:0045893; GO:0003700; GO:0035914; GO:0006366 P0CG48 "DNA binding; Golgi apparatus; angiogenesis; metal ion binding; microvillus assembly; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; skeletal muscle cell differentiation; transcription from RNA polymerase II promoter" IPR007087; IPR015880; IPR013087; Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2) KLF5 BTEB2 CKLF IKLF Homo sapiens (Human) TR41300_c1_g1_i8 Q00453 RGM1_YEAST 1.00E-07 GO:0003677; GO:0005829; GO:0046872; GO:0000790; GO:0045944; GO:0000981 P39940 DNA binding; cytosol; metal ion binding; nuclear chromatin; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR007087; IPR015880; IPR013087; Probable transcription repressor protein RGM1 RGM1 YMR182C YM8010.12C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41302_c0_g1_i3 A6QLZ5 F177A_BOVIN 5.00E-18 IPR028260; Protein FAM177A1 FAM177A1 Bos taurus (Bovine) TR41302_c0_g3_i1 Q8BR63 F177A_MOUSE 5.00E-08 IPR028260; Protein FAM177A1 Fam177a1 Mus musculus (Mouse) TR41303_c1_g3_i1 Q5ZKQ3 RPAP3_CHICK 1.00E-06 IPR025986; IPR013026; IPR011990; IPR001440; IPR019734; RNA polymerase II-associated protein 3 RPAP3 RCJMB04_9l4 Gallus gallus (Chicken) TR41303_c1_g3_i2 Q9CX34 SUGT1_MOUSE 6.00E-89 GO:0005737; GO:0005634 cytoplasm; nucleus IPR007052; IPR008978; IPR007699; IPR013026; IPR011990; IPR013105; IPR019734; Suppressor of G2 allele of SKP1 homolog Sugt1 Mus musculus (Mouse) TR41303_c1_g3_i3 Q84K11 PPP5_SOLLC 5.00E-14 GO:0005789; GO:0016021; GO:0046872; GO:0031965; GO:0016607; GO:0004721; GO:0006470 endoplasmic reticulum membrane; integral to membrane; metal ion binding; nuclear membrane; nuclear speck; phosphoprotein phosphatase activity; protein dephosphorylation IPR004843; IPR000909; IPR013235; IPR006186; IPR011236; IPR013026; IPR011990; IPR001440; IPR019734; Serine/threonine-protein phosphatase 5 (EC 3.1.3.16) (LePP5) PP5 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) TR41303_c1_g3_i4 Q96AY4 TTC28_HUMAN 8.00E-11 GO:0051301; GO:0005737; GO:0005815; GO:0030496; GO:0007067; GO:0000922 cell division; cytoplasm; microtubule organizing center; midbody; mitosis; spindle pole IPR024983; IPR013026; IPR011990; IPR001440; IPR013105; IPR019734; Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) TTC28 KIAA1043 TPRBK Homo sapiens (Human) TR41303_c1_g3_i5 Q9CX34 SUGT1_MOUSE 3.00E-86 GO:0005737; GO:0005634 cytoplasm; nucleus IPR007052; IPR008978; IPR007699; IPR013026; IPR011990; IPR013105; IPR019734; Suppressor of G2 allele of SKP1 homolog Sugt1 Mus musculus (Mouse) TR41303_c1_g3_i6 Q9SUR9 SGT1A_ARATH 3.00E-55 GO:0019005; GO:0071365; GO:0006952; GO:0045087; GO:0005634; GO:2000072; GO:0006511 Q7XJ80; Q0Q0I7 "SCF ubiquitin ligase complex; cellular response to auxin stimulus; defense response; innate immune response; nucleus; regulation of defense response to fungus, incompatible interaction; ubiquitin-dependent protein catabolic process" IPR007052; IPR008978; IPR007699; IPR013026; IPR011990; IPR001440; IPR019734; Protein SGT1 homolog A (AtSGT1a) (Suppressor of G2 allele of SKP1 homolog A) SGT1A At4g23570 F9D16.40 Arabidopsis thaliana (Mouse-ear cress) TR41305_c0_g3_i1 Q9ULL4 PLXB3_HUMAN 4.00E-81 GO:0007411; GO:0016021; GO:0005622; GO:0005886; GO:0004872; GO:0007165 Q16658; P08581; Q04912 axon guidance; integral to membrane; intracellular; plasma membrane; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-B3 PLXNB3 KIAA1206 PLXN6 Homo sapiens (Human) TR41306_c0_g3_i1 Q1JQE0 SNW1_BOVIN 7.00E-149 GO:0046332; GO:0071146; GO:0071013; GO:0071300; GO:0042771; GO:0000398; GO:0000122; GO:0016363; GO:0043923; GO:0051571; GO:0048026; GO:0050769; GO:0045944; GO:0030511; GO:0070564; GO:0008024; GO:0048385; GO:0070562; GO:0042974; GO:0048384; GO:0003713; GO:0003714; GO:0006351; GO:0042809 "SMAD binding; SMAD3-SMAD4 protein complex; catalytic step 2 spliceosome; cellular response to retinoic acid; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; mRNA splicing, via spliceosome; negative regulation of transcription from RNA polymerase II promoter; nuclear matrix; positive regulation by host of viral transcription; positive regulation of histone H3-K4 methylation; positive regulation of mRNA splicing, via spliceosome; positive regulation of neurogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of vitamin D receptor signaling pathway; positive transcription elongation factor complex b; regulation of retinoic acid receptor signaling pathway; regulation of vitamin D receptor signaling pathway; retinoic acid receptor binding; retinoic acid receptor signaling pathway; transcription coactivator activity; transcription corepressor activity; transcription, DNA-dependent; vitamin D receptor binding" IPR017862; IPR004015; SNW domain-containing protein 1 (Nuclear protein SkiP) (Ski-interacting protein) SNW1 SKIIP Bos taurus (Bovine) TR41308_c1_g1_i1 P49915 GUAA_HUMAN 0 GO:0005524; GO:0003922; GO:0003921; GO:0005829; GO:0006541; GO:0009113; GO:0016462 ATP binding; GMP synthase (glutamine-hydrolyzing) activity; GMP synthase activity; cytosol; glutamine metabolic process; purine nucleobase biosynthetic process; pyrophosphatase activity IPR017926; IPR001674; IPR004739; IPR025777; IPR022310; IPR014729; Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) GMPS Homo sapiens (Human) TR41309_c0_g1_i1 Q3YEC7 RABL6_HUMAN 1.00E-90 GO:0005525; GO:0005813; GO:0005737; GO:0005634; GO:0007264 Q99750; P58062 GTP binding; centrosome; cytoplasm; nucleus; small GTPase mediated signal transduction IPR013684; IPR027417; IPR001806; Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1) RABL6 C9orf86 PARF Homo sapiens (Human) TR41309_c0_g1_i2 Q3YEC7 RABL6_HUMAN 1.00E-90 GO:0005525; GO:0005813; GO:0005737; GO:0005634; GO:0007264 Q99750; P58062 GTP binding; centrosome; cytoplasm; nucleus; small GTPase mediated signal transduction IPR013684; IPR027417; IPR001806; Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1) RABL6 C9orf86 PARF Homo sapiens (Human) TR41309_c2_g2_i2 Q4ZHG4 FNDC1_HUMAN 1.00E-20 GO:0005911; GO:0071456; GO:0005576; GO:0031966; GO:0005886; GO:0010666; GO:0001934; GO:0051223 cell-cell junction; cellular response to hypoxia; extracellular region; mitochondrial membrane; plasma membrane; positive regulation of cardiac muscle cell apoptotic process; positive regulation of protein phosphorylation; regulation of protein transport IPR003961; IPR013783; Fibronectin type III domain-containing protein 1 (Activation-associated cDNA protein) (Expressed in synovial lining protein) FNDC1 FNDC2 KIAA1866 MEL4B3 Homo sapiens (Human) TR41311_c0_g3_i1 Q7ZUV7 EMSY_DANRE 2.00E-66 GO:0006281; GO:0016568; GO:0005634; GO:0006355; GO:0006351 "DNA repair; chromatin modification; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR005491; Protein EMSY emsy zgc:56039 Danio rerio (Zebrafish) (Brachydanio rerio) TR41311_c0_g4_i1 Q12830 BPTF_HUMAN 5.00E-14 GO:0016589; GO:0009952; GO:0007420; GO:0006338; GO:0005737; GO:0001892; GO:0007492; GO:0000122; GO:0045893; GO:0043565; GO:0008134; GO:0006351; GO:0008270 Q71DI3; P62805 "NURF complex; anterior/posterior pattern specification; brain development; chromatin remodeling; cytoplasm; embryonic placenta development; endoderm development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription factor binding; transcription, DNA-dependent; zinc ion binding" IPR001487; IPR018359; IPR004022; IPR018500; IPR018501; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) BPTF FAC1 FALZ Homo sapiens (Human) TR41311_c0_g4_i6 Q9LS28 GTE12_ARATH 1.00E-10 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001487; Transcription factor GTE12 (Bromodomain-containing protein GTE12) (Protein GLOBAL TRANSCRIPTION FACTOR GROUP E12) GTE12 At5g46550 F10E10.2 Arabidopsis thaliana (Mouse-ear cress) TR41312_c0_g2_i3 Q6BEA0 PLXA4_DANRE 8.00E-92 GO:0007411; GO:0007414; GO:0016021; GO:0005622; GO:0001763; GO:0005886; GO:0004872; GO:0007165 axon guidance; axonal defasciculation; integral to membrane; intracellular; morphogenesis of a branching structure; plasma membrane; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A4 plxna4 Danio rerio (Zebrafish) (Brachydanio rerio) TR41312_c0_g3_i1 Q9V4A7 PLXB_DROME 2.00E-91 GO:0016021; GO:0005622; GO:0008045; GO:0035021; GO:0005886; GO:0035025; GO:0004872; GO:0007165 integral to membrane; intracellular; motor neuron axon guidance; negative regulation of Rac protein signal transduction; plasma membrane; positive regulation of Rho protein signal transduction; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-B plexB CG17245 Drosophila melanogaster (Fruit fly) TR41312_c0_g5_i2 Q80UG2 PLXA4_MOUSE 6.00E-153 GO:0021960; GO:0021793; GO:0021610; GO:0021615; GO:0016021; GO:0005622; GO:0005886; GO:0021784; GO:0048841; GO:0050923; GO:0017154; GO:0048485; GO:0021636; GO:0021644 O35464 anterior commissure morphogenesis; chemorepulsion of branchiomotor axon; facial nerve morphogenesis; glossopharyngeal nerve morphogenesis; integral to membrane; intracellular; plasma membrane; postganglionic parasympathetic nervous system development; regulation of axon extension involved in axon guidance; regulation of negative chemotaxis; semaphorin receptor activity; sympathetic nervous system development; trigeminal nerve morphogenesis; vagus nerve morphogenesis IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A4 Plxna4 Kiaa1550 Mus musculus (Mouse) TR41313_c0_g1_i1 Q06455 MTG8_HUMAN 5.00E-145 GO:0003677; GO:0045444; GO:0006091; GO:0046872; GO:0016363; GO:0051101; GO:0003700; GO:0006351 Itself; P08047 "DNA binding; fat cell differentiation; generation of precursor metabolites and energy; metal ion binding; nuclear matrix; regulation of DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR013289; IPR013290; IPR014896; IPR003894; IPR002893; Protein CBFA2T1 (Cyclin-D-related protein) (Eight twenty one protein) (Protein ETO) (Protein MTG8) (Zinc finger MYND domain-containing protein 2) RUNX1T1 AML1T1 CBFA2T1 CDR ETO MTG8 ZMYND2 Homo sapiens (Human) TR41313_c0_g1_i2 O75081 MTG16_HUMAN 3.00E-141 GO:0000139; GO:0008283; GO:0003682; GO:0030851; GO:0046872; GO:0005730; GO:0005654; GO:0045944; GO:0003700; GO:0006351 P51805; Q9Y2D9 "Golgi membrane; cell proliferation; chromatin binding; granulocyte differentiation; metal ion binding; nucleolus; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR013289; IPR013292; IPR014896; IPR003894; IPR002893; Protein CBFA2T3 (MTG8-related protein 2) (Myeloid translocation gene on chromosome 16 protein) (hMTG16) (Zinc finger MYND domain-containing protein 4) CBFA2T3 MTG16 MTGR2 ZMYND4 Homo sapiens (Human) TR41314_c3_g1_i1 Q9DGJ3 NPC2_DANRE 2.00E-27 GO:0008203; GO:0005783; GO:0005576 cholesterol metabolic process; endoplasmic reticulum; extracellular region IPR014756; IPR003172; Epididymal secretory protein E1 (16.5 kDa secretory protein) (Niemann Pick type C2 protein homolog) npc2 Danio rerio (Zebrafish) (Brachydanio rerio) TR41314_c5_g2_i1 Q6GLJ1 BTBDH_XENLA 1.00E-35 GO:0005576 extracellular region IPR011705; IPR000210; IPR011333; IPR013069; BTB/POZ domain-containing protein 17 btbd17 Xenopus laevis (African clawed frog) TR41315_c0_g1_i3 Q00719 MDMC_STRMY 5.00E-24 GO:0008171; GO:0017000; GO:0046872 O-methyltransferase activity; antibiotic biosynthetic process; metal ion binding IPR002935; O-methyltransferase MdmC (EC 2.1.1.-) mdmC Streptomyces mycarofaciens TR41315_c1_g1_i4 P48818 ACADV_BOVIN 0 GO:0003995; GO:0033539; GO:0050660; GO:0005743; GO:0045717; GO:0046322; GO:0090181; GO:0001659 acyl-CoA dehydrogenase activity; fatty acid beta-oxidation using acyl-CoA dehydrogenase; flavin adenine dinucleotide binding; mitochondrial inner membrane; negative regulation of fatty acid biosynthetic process; negative regulation of fatty acid oxidation; regulation of cholesterol metabolic process; temperature homeostasis IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Lipid metabolism; mitochondrial fatty acid beta-oxidation. "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9)" ACADVL VLCAD Bos taurus (Bovine) TR41316_c0_g1_i1 A4FUM1 SEP8B_DANRE 3.00E-99 GO:0005525; GO:0007049; GO:0031105 GTP binding; cell cycle; septin complex IPR000038; IPR027417; IPR016491; Septin-8-B sept8b Danio rerio (Zebrafish) (Brachydanio rerio) TR41316_c0_g2_i1 P39826 CDC3_CANAX 6.00E-49 GO:0005525; GO:0007049; GO:0051301; GO:0005935; GO:0031105 GTP binding; cell cycle; cell division; cellular bud neck; septin complex IPR000038; IPR027417; IPR016491; Cell division control protein 3 CDC3 Candida albicans (Yeast) TR41316_c0_g2_i3 Q9UH03 SEPT3_HUMAN 2.00E-52 GO:0005525; GO:0030054; GO:0000910; GO:0031105; GO:0045202 GTP binding; cell junction; cytokinesis; septin complex; synapse IPR000038; IPR027417; IPR016491; IPR008114; Neuronal-specific septin-3 SEPT3 SEP3 Homo sapiens (Human) TR41318_c1_g1_i1 P22274 ARF_CANAL 4.00E-23 GO:0005525; GO:0003924; GO:0005794; GO:0035690; GO:0015031; GO:0007264; GO:0016192 GTP binding; GTPase activity; Golgi apparatus; cellular response to drug; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor ARF1 CaO19.13805 CaO19.6447 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) TR4132_c0_g1_i1 Q9CY58 PAIRB_MOUSE 5.00E-07 GO:0003730; GO:0005634; GO:0048471; GO:0005886 mRNA 3'-UTR binding; nucleus; perinuclear region of cytoplasm; plasma membrane IPR006861; IPR027205; Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA-binding protein 1) (PAI-RBP1) (SERPINE1 mRNA-binding protein 1) Serbp1 Pairbp1 Mus musculus (Mouse) TR41321_c1_g1_i1 O08688 CAN5_MOUSE 1.00E-178 GO:0004198; GO:0009986; GO:0005622; GO:0006508 calcium-dependent cysteine-type endopeptidase activity; cell surface; intracellular; proteolysis IPR000008; IPR022684; IPR022682; IPR022683; IPR000169; IPR001300; Calpain-5 (EC 3.4.22.-) (New calpain 3) (nCL-3) Capn5 Ncl3 Mus musculus (Mouse) TR41321_c1_g1_i2 Q92177 CAN3_CHICK 8.00E-91 GO:0030315; GO:0030018; GO:0005509; GO:0004198; GO:0071277; GO:0071472; GO:0005829; GO:0055103; GO:0043066; GO:0033234; GO:0045892; GO:0005634; GO:0051092; GO:0045862; GO:0051281; GO:0014718; GO:0045893; GO:0043234; GO:0006461; GO:0032947; GO:0072657; GO:0043122; GO:0014850; GO:0045214; GO:0097264; GO:0031402; GO:0008307; GO:0031432 "T-tubule; Z disc; calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cellular response to calcium ion; cellular response to salt stress; cytosol; ligase regulator activity; negative regulation of apoptotic process; negative regulation of protein sumoylation; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of proteolysis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of satellite cell activation involved in skeletal muscle regeneration; positive regulation of transcription, DNA-dependent; protein complex; protein complex assembly; protein complex scaffold; protein localization to membrane; regulation of I-kappaB kinase/NF-kappaB cascade; response to muscle activity; sarcomere organization; self proteolysis; sodium ion binding; structural constituent of muscle; titin binding" IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) CAPN3 Gallus gallus (Chicken) TR41321_c1_g1_i3 Q22036 CAN5_CAEEL 7.00E-140 GO:0004198; GO:0030154; GO:0019099; GO:0042004; GO:0005622; GO:0016020; GO:0031293; GO:0016540; GO:0007548 calcium-dependent cysteine-type endopeptidase activity; cell differentiation; female germ-line sex determination; feminization of hermaphrodite soma; intracellular; membrane; membrane protein intracellular domain proteolysis; protein autoprocessing; sex differentiation IPR000008; IPR022684; IPR022682; IPR022683; IPR000169; IPR001300; Calpain-5 (EC 3.4.22.-) (Sex-determining transformer protein 3) tra-3 clp-5 LLC1.1 Caenorhabditis elegans TR41321_c1_g1_i4 O08688 CAN5_MOUSE 2.00E-94 GO:0004198; GO:0009986; GO:0005622; GO:0006508 calcium-dependent cysteine-type endopeptidase activity; cell surface; intracellular; proteolysis IPR000008; IPR022684; IPR022682; IPR022683; IPR000169; IPR001300; Calpain-5 (EC 3.4.22.-) (New calpain 3) (nCL-3) Capn5 Ncl3 Mus musculus (Mouse) TR41322_c1_g1_i2 Q8C8H8 KY_MOUSE 1.00E-45 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) TR41322_c1_g1_i3 Q8C8H8 KY_MOUSE 1.00E-46 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) TR41322_c1_g1_i8 Q8C8H8 KY_MOUSE 5.00E-47 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) TR41323_c0_g1_i1 P38769 YHJ5_YEAST 8.00E-10 GO:0030127; GO:0006888; GO:0006886; GO:0008270 COPII vesicle coat; ER to Golgi vesicle-mediated transport; intracellular protein transport; zinc ion binding IPR006896; IPR002035; IPR006895; Uncharacterized protein YHR035W YHR035W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41323_c0_g1_i2 Q7SZE5 SC23A_DANRE 0 GO:0030127; GO:0006888; GO:0000139; GO:0051216; GO:0048702; GO:0006886; GO:0035138; GO:0030868; GO:0008270 COPII vesicle coat; ER to Golgi vesicle-mediated transport; Golgi membrane; cartilage development; embryonic neurocranium morphogenesis; intracellular protein transport; pectoral fin morphogenesis; smooth endoplasmic reticulum membrane; zinc ion binding IPR007123; IPR006900; IPR006896; IPR012990; IPR002035; IPR006895; Protein transport protein Sec23A (SEC23-related protein A) sec23a Danio rerio (Zebrafish) (Brachydanio rerio) TR41323_c0_g1_i3 Q4PE39 SEC23_USTMA 0 GO:0030127; GO:0006888; GO:0000139; GO:0005789; GO:0006886; GO:0008270 COPII vesicle coat; ER to Golgi vesicle-mediated transport; Golgi membrane; endoplasmic reticulum membrane; intracellular protein transport; zinc ion binding IPR007123; IPR006900; IPR006896; IPR012990; IPR002035; IPR006895; Protein transport protein SEC23 SEC23 UM01624 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR41323_c0_g1_i4 A4R1J7 SEC23_MAGO7 0 GO:0030127; GO:0006888; GO:0000139; GO:0005789; GO:0006886; GO:0043581; GO:0008270 COPII vesicle coat; ER to Golgi vesicle-mediated transport; Golgi membrane; endoplasmic reticulum membrane; intracellular protein transport; mycelium development; zinc ion binding IPR007123; IPR006900; IPR006896; IPR012990; IPR002035; IPR006895; Protein transport protein SEC23 SEC23 MGG_06910 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) TR41323_c0_g1_i5 A4R1J7 SEC23_MAGO7 0 GO:0030127; GO:0006888; GO:0000139; GO:0005789; GO:0006886; GO:0043581; GO:0008270 COPII vesicle coat; ER to Golgi vesicle-mediated transport; Golgi membrane; endoplasmic reticulum membrane; intracellular protein transport; mycelium development; zinc ion binding IPR007123; IPR006900; IPR006896; IPR012990; IPR002035; IPR006895; Protein transport protein SEC23 SEC23 MGG_06910 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) TR41323_c0_g1_i6 P0CR38 SEC23_CRYNJ 0 GO:0030127; GO:0006888; GO:0000139; GO:0005789; GO:0006886; GO:0008270 COPII vesicle coat; ER to Golgi vesicle-mediated transport; Golgi membrane; endoplasmic reticulum membrane; intracellular protein transport; zinc ion binding IPR007123; IPR006900; IPR006896; IPR012990; IPR002035; IPR006895; Protein transport protein SEC23 SEC23 CNJ01150 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR41323_c0_g1_i7 Q7SZE5 SC23A_DANRE 0 GO:0030127; GO:0006888; GO:0000139; GO:0051216; GO:0048702; GO:0006886; GO:0035138; GO:0030868; GO:0008270 COPII vesicle coat; ER to Golgi vesicle-mediated transport; Golgi membrane; cartilage development; embryonic neurocranium morphogenesis; intracellular protein transport; pectoral fin morphogenesis; smooth endoplasmic reticulum membrane; zinc ion binding IPR007123; IPR006900; IPR006896; IPR012990; IPR002035; IPR006895; Protein transport protein Sec23A (SEC23-related protein A) sec23a Danio rerio (Zebrafish) (Brachydanio rerio) TR41324_c0_g2_i1 Q9WJR5 POK3_HUMAN 3.00E-11 GO:0003677; GO:0015074; GO:0006310; GO:0003723; GO:0006278; GO:0003964; GO:0090305; GO:0004523; GO:0008270 DNA binding; DNA integration; DNA recombination; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; nucleic acid phosphodiester bond hydrolysis; ribonuclease H activity; zinc ion binding IPR001037; IPR001584; IPR017856; IPR003308; IPR012337; IPR002156; IPR000477; IPR010661; HERV-K_19q12 provirus ancestral Pol protein (HERV-K(C19) Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)] ERVK6 Homo sapiens (Human) TR41324_c0_g2_i2 Q7LHG5 YI31B_YEAST 5.00E-65 GO:0005524; GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0005737; GO:0008233; GO:0006508; GO:0000943; GO:0004523; GO:0004540; GO:0032197; GO:0046797; GO:0008270 "ATP binding; DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; cytoplasm; peptidase activity; proteolysis; retrotransposon nucleocapsid; ribonuclease H activity; ribonuclease activity; transposition, RNA-mediated; viral procapsid maturation; zinc ion binding" IPR001584; IPR024650; IPR021109; IPR005162; IPR012337; IPR000477; IPR001878; Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41324_c0_g2_i3 Q09575 YRD6_CAEEL 1.00E-35 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR41325_c0_g2_i1 Q95T12 FLOWR_DROME 4.00E-28 GO:0005262; GO:0030054; GO:0044214; GO:0030285; GO:0046530; GO:0042981; GO:0048488 Itself calcium channel activity; cell junction; fully spanning plasma membrane; integral to synaptic vesicle membrane; photoreceptor cell differentiation; regulation of apoptotic process; synaptic vesicle endocytosis IPR024947; IPR019365; Calcium channel flower (3L5) fwe flower CG6151 Drosophila melanogaster (Fruit fly) TR41326_c0_g2_i1 P38621 ZN12_MICSA 2.00E-39 GO:0003677; GO:0046872; GO:0005634 DNA binding; metal ion binding; nucleus IPR007087; IPR015880; IPR013087; Zinc finger protein ZFMSA12A Micropterus salmoides (Largemouth bass) (Labrus salmoides) TR41327_c2_g1_i1 Q9PD85 Y1494_XYLFA 2.00E-16 IPR013026; IPR011990; IPR013105; IPR019734; UPF0162 protein XF_1494 XF_1494 Xylella fastidiosa (strain 9a5c) TR41327_c2_g1_i3 Q5R5S1 FBX21_PONAB 7.00E-91 GO:0003677 DNA binding IPR001810; IPR011722; F-box only protein 21 FBXO21 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41327_c2_g1_i4 Q5R5S1 FBX21_PONAB 1.00E-90 GO:0003677 DNA binding IPR001810; IPR011722; F-box only protein 21 FBXO21 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41328_c0_g7_i5 Q96KR6 F210B_HUMAN 6.00E-39 GO:0016021 integral to membrane IPR009688; Protein FAM210B FAM210B C20orf108 PSEC0265 Homo sapiens (Human) TR41329_c6_g1_i1 Q60648 SAP3_MOUSE 1.00E-30 GO:0004563; GO:0008047; GO:0006689; GO:0007611; GO:0019915; GO:0005764; GO:0005739; GO:0050885; GO:0005730; GO:0009313 beta-N-acetylhexosaminidase activity; enzyme activator activity; ganglioside catabolic process; learning or memory; lipid storage; lysosome; mitochondrion; neuromuscular process controlling balance; nucleolus; oligosaccharide catabolic process IPR003172; Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) Gm2a Mus musculus (Mouse) TR41330_c0_g4_i1 P86854 PLCL_MYTGA 2.00E-09 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR41330_c0_g4_i3 Q6EIG7 CLC6A_HUMAN 1.00E-07 GO:0030246; GO:0050832; GO:0045087; GO:0016021; GO:0043123; GO:0050715 carbohydrate binding; defense response to fungus; innate immune response; integral to membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of cytokine secretion IPR001304; IPR016186; IPR016187; C-type lectin domain family 6 member A (C-type lectin superfamily member 10) (Dendritic cell-associated C-type lectin 2) (DC-associated C-type lectin 2) (Dectin-2) CLEC6A CLECSF10 DECTIN2 Homo sapiens (Human) TR41330_c0_g4_i6 P86854 PLCL_MYTGA 4.00E-09 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR41330_c0_g6_i1 Q8VD98 KLRBF_MOUSE 6.00E-07 GO:0030246; GO:0009986; GO:0016021; GO:0005886; GO:0004872 carbohydrate binding; cell surface; integral to membrane; plasma membrane; receptor activity IPR001304; IPR016186; IPR016187; Killer cell lectin-like receptor subfamily B member 1F (CD161 antigen-like family member F) (Natural killer cell surface protein NKR-P1F) (CD antigen CD161f) Klrb1f Nkrp1f Mus musculus (Mouse) TR41331_c1_g1_i1 Q16773 KAT1_HUMAN 1.00E-73 GO:0047945; GO:0097053; GO:0006559; GO:0036141; GO:0047312; GO:0008652; GO:0047804; GO:0005829; GO:0047316; GO:0016212; GO:0005634; GO:0030170; GO:0006569 L-glutamine:pyruvate aminotransferase activity; L-kynurenine catabolic process; L-phenylalanine catabolic process; L-phenylalanine-oxaloacetate transaminase activity; L-phenylalanine:pyruvate aminotransferase activity; cellular amino acid biosynthetic process; cysteine-S-conjugate beta-lyase activity; cytosol; glutamine-phenylpyruvate transaminase activity; kynurenine-oxoglutarate transaminase activity; nucleus; pyridoxal phosphate binding; tryptophan catabolic process IPR004839; IPR015424; IPR015421; IPR015422; Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2. Kynurenine--oxoglutarate transaminase 1 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase) (EC 4.4.1.13) (Glutamine transaminase K) (GTK) (Glutamine--phenylpyruvate transaminase) (EC 2.6.1.64) (Kynurenine aminotransferase I) (KATI) (Kynurenine--oxoglutarate transaminase I) CCBL1 Homo sapiens (Human) TR41331_c1_g1_i4 Q16773 KAT1_HUMAN 4.00E-74 GO:0047945; GO:0097053; GO:0006559; GO:0036141; GO:0047312; GO:0008652; GO:0047804; GO:0005829; GO:0047316; GO:0016212; GO:0005634; GO:0030170; GO:0006569 L-glutamine:pyruvate aminotransferase activity; L-kynurenine catabolic process; L-phenylalanine catabolic process; L-phenylalanine-oxaloacetate transaminase activity; L-phenylalanine:pyruvate aminotransferase activity; cellular amino acid biosynthetic process; cysteine-S-conjugate beta-lyase activity; cytosol; glutamine-phenylpyruvate transaminase activity; kynurenine-oxoglutarate transaminase activity; nucleus; pyridoxal phosphate binding; tryptophan catabolic process IPR004839; IPR015424; IPR015421; IPR015422; Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2. Kynurenine--oxoglutarate transaminase 1 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase) (EC 4.4.1.13) (Glutamine transaminase K) (GTK) (Glutamine--phenylpyruvate transaminase) (EC 2.6.1.64) (Kynurenine aminotransferase I) (KATI) (Kynurenine--oxoglutarate transaminase I) CCBL1 Homo sapiens (Human) TR41331_c1_g1_i5 O31665 MTNE_BACSU 1.00E-16 GO:0019509; GO:0030170; GO:0008483 L-methionine salvage from methylthioadenosine; pyridoxal phosphate binding; transaminase activity IPR004839; IPR015424; IPR015421; IPR015422; Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 6/6. Transaminase MtnE (EC 2.6.1.-) mtnE mtnV ykrV BSU13580 Bacillus subtilis (strain 168) TR41331_c1_g2_i3 Q6YP21 KAT3_HUMAN 2.00E-85 GO:0006103; GO:0009058; GO:0047804; GO:0047315; GO:0016212; GO:0005739; GO:0030170; GO:0006569 2-oxoglutarate metabolic process; biosynthetic process; cysteine-S-conjugate beta-lyase activity; kynurenine-glyoxylate transaminase activity; kynurenine-oxoglutarate transaminase activity; mitochondrion; pyridoxal phosphate binding; tryptophan catabolic process IPR004839; IPR015424; IPR015421; IPR015422; Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III) CCBL2 KAT3 Homo sapiens (Human) TR41331_c1_g2_i5 Q7T3E5 KAT3_DANRE 2.00E-81 GO:0009058; GO:0047804; GO:0047315; GO:0016212; GO:0030170 biosynthetic process; cysteine-S-conjugate beta-lyase activity; kynurenine-glyoxylate transaminase activity; kynurenine-oxoglutarate transaminase activity; pyridoxal phosphate binding IPR004839; IPR015424; IPR015421; IPR015422; Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III) ccbl2 kat3 zgc:63929 Danio rerio (Zebrafish) (Brachydanio rerio) TR41331_c1_g2_i8 Q6YP21 KAT3_HUMAN 3.00E-85 GO:0006103; GO:0009058; GO:0047804; GO:0047315; GO:0016212; GO:0005739; GO:0030170; GO:0006569 2-oxoglutarate metabolic process; biosynthetic process; cysteine-S-conjugate beta-lyase activity; kynurenine-glyoxylate transaminase activity; kynurenine-oxoglutarate transaminase activity; mitochondrion; pyridoxal phosphate binding; tryptophan catabolic process IPR004839; IPR015424; IPR015421; IPR015422; Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III) CCBL2 KAT3 Homo sapiens (Human) TR41332_c1_g3_i1 Q641Z2 PTN9_RAT 3.00E-93 GO:0005737; GO:0004725 cytoplasm; protein tyrosine phosphatase activity IPR001251; IPR011074; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) Ptpn9 Rattus norvegicus (Rat) TR41334_c1_g1_i1 Q5ZIN2 SEN2_CHICK 2.00E-25 GO:0006397; GO:0003676; GO:0090305; GO:0006388; GO:0000213; GO:0000214 "mRNA processing; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis; tRNA splicing, via endonucleolytic cleavage and ligation; tRNA-intron endonuclease activity; tRNA-intron endonuclease complex" IPR011856; IPR006677; IPR006678; IPR016589; tRNA-splicing endonuclease subunit Sen2 (EC 3.1.27.9) (tRNA-intron endonuclease Sen2) TSEN2 RCJMB04_24m3 Gallus gallus (Chicken) TR41338_c3_g2_i1 Q9NBX4 RTXE_DROME 7.00E-24 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR41338_c4_g1_i1 Q9Y6N5 SQRD_HUMAN 2.00E-157 GO:0034641; GO:0005743; GO:0070221; GO:0070224; GO:0000098 "cellular nitrogen compound metabolic process; mitochondrial inner membrane; sulfide oxidation, using sulfide:quinone oxidoreductase; sulfide:quinone oxidoreductase activity; sulfur amino acid catabolic process" IPR023753; IPR015904; "Sulfide:quinone oxidoreductase, mitochondrial (EC 1.-.-.-)" SQRDL CGI-44 Homo sapiens (Human) TR41338_c4_g1_i2 Q54DK1 SQRD_DICDI 7.00E-98 GO:0005739; GO:0016491; GO:0042762 mitochondrion; oxidoreductase activity; regulation of sulfur metabolic process IPR023753; IPR015904; "Sulfide:quinone oxidoreductase, mitochondrial (EC 1.-.-.-)" sqrdl DDB_G0292250 Dictyostelium discoideum (Slime mold) TR41338_c4_g1_i6 Q9Y6N5 SQRD_HUMAN 4.00E-15 GO:0034641; GO:0005743; GO:0070221; GO:0070224; GO:0000098 "cellular nitrogen compound metabolic process; mitochondrial inner membrane; sulfide oxidation, using sulfide:quinone oxidoreductase; sulfide:quinone oxidoreductase activity; sulfur amino acid catabolic process" IPR023753; IPR015904; "Sulfide:quinone oxidoreductase, mitochondrial (EC 1.-.-.-)" SQRDL CGI-44 Homo sapiens (Human) TR41339_c0_g1_i3 O94985 CSTN1_HUMAN 1.00E-24 GO:0000139; GO:0005509; GO:0030054; GO:0042995; GO:0005789; GO:0005576; GO:0007156; GO:0016021; GO:0005634; GO:0045211 Q8CD76 Golgi membrane; calcium ion binding; cell junction; cell projection; endoplasmic reticulum membrane; extracellular region; homophilic cell adhesion; integral to membrane; nucleus; postsynaptic membrane IPR002126; IPR015919; IPR026914; IPR008985; IPR013320; Calsyntenin-1 (Alcadein-alpha) (Alc-alpha) (Alzheimer-related cadherin-like protein) (Non-classical cadherin XB31alpha) [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)] CLSTN1 CS1 KIAA0911 Homo sapiens (Human) TR41339_c0_g2_i1 Q9ER65 CSTN2_MOUSE 7.00E-151 GO:0000139; GO:0005509; GO:0005789; GO:0007156; GO:0016021; GO:0045211 Golgi membrane; calcium ion binding; endoplasmic reticulum membrane; homophilic cell adhesion; integral to membrane; postsynaptic membrane IPR002126; IPR015919; IPR026914; IPR008985; IPR013320; Calsyntenin-2 (Alcadein-gamma) (Alc-gamma) Clstn2 Cs2 Cstn2 Kiaa4134 Mus musculus (Mouse) TR41343_c6_g1_i10 Q63HN8 RN213_HUMAN 5.00E-22 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR018957; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) TR41343_c6_g1_i2 Q63HN8 RN213_HUMAN 1.00E-36 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR018957; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) TR41343_c6_g1_i5 E9Q555 RN213_MOUSE 4.00E-30 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) Rnf213 Mus musculus (Mouse) TR41344_c1_g3_i5 Q5BIM1 TRI45_BOVIN 3.00E-06 GO:0005737; GO:0005634; GO:0008270 cytoplasm; nucleus; zinc ion binding IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) TR41344_c1_g3_i6 Q5BIM1 TRI45_BOVIN 2.00E-06 GO:0005737; GO:0005634; GO:0008270 cytoplasm; nucleus; zinc ion binding IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) TR41345_c0_g1_i1 Q9EPZ7 SO1C1_RAT 2.00E-79 GO:0015125; GO:0016021; GO:0005886 bile acid transmembrane transporter activity; integral to membrane; plasma membrane IPR002350; IPR020846; IPR016196; IPR004156; Solute carrier organic anion transporter family member 1C1 (BBB-specific anion transporter type 1) (Blood-brain barrier-specific anion transporter 1) (Solute carrier family 21 member 14) (Thyroxine transporter) Slco1c1 Bsat1 Oatp1c1 Oatpf Slc21a14 Rattus norvegicus (Rat) TR41347_c0_g1_i1 Q7ZWP1 FRMD8_XENLA 2.00E-56 GO:0005856 cytoskeleton IPR019749; IPR014352; IPR019748; IPR000299; FERM domain-containing protein 8 frmd8 Xenopus laevis (African clawed frog) TR41348_c0_g3_i2 Q5RBP4 EHD1_PONAB 0 GO:0005524; GO:0005525; GO:0006184; GO:0003924; GO:0005509; GO:1990090; GO:0042632; GO:0031901; GO:0032456; GO:0030139; GO:0006897; GO:0006886; GO:0005811; GO:0034383; GO:0031175; GO:0048471; GO:0005886; GO:0031095; GO:0010886; GO:2001137; GO:1901741; GO:0051260; GO:0055038 ATP binding; GTP binding; GTP catabolic process; GTPase activity; calcium ion binding; cellular response to nerve growth factor stimulus; cholesterol homeostasis; early endosome membrane; endocytic recycling; endocytic vesicle; endocytosis; intracellular protein transport; lipid particle; low-density lipoprotein particle clearance; neuron projection development; perinuclear region of cytoplasm; plasma membrane; platelet dense tubular network membrane; positive regulation of cholesterol storage; positive regulation of endocytic recycling; positive regulation of myoblast fusion; protein homooligomerization; recycling endosome membrane IPR001401; IPR011992; IPR018247; IPR002048; IPR000261; IPR027417; EH domain-containing protein 1 EHD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41348_c0_g3_i3 P42566 EPS15_HUMAN 1.00E-18 GO:0030122; GO:0005509; GO:0008283; GO:0060170; GO:0048268; GO:0005905; GO:0005829; GO:0031901; GO:0032456; GO:0006897; GO:0007173; GO:0043231; GO:0042059; GO:0005886; GO:0015031 Q0JRZ9; Q3UQN2; P16333; Q8WXE9; Q9UMX0 AP-2 adaptor complex; calcium ion binding; cell proliferation; cilium membrane; clathrin coat assembly; coated pit; cytosol; early endosome membrane; endocytic recycling; endocytosis; epidermal growth factor receptor signaling pathway; intracellular membrane-bounded organelle; negative regulation of epidermal growth factor receptor signaling pathway; plasma membrane; protein transport IPR011992; IPR018247; IPR002048; IPR000261; IPR003903; Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) EPS15 AF1P Homo sapiens (Human) TR41349_c1_g2_i5 Q8TB36 GDAP1_HUMAN 2.00E-24 GO:0031307; GO:0000266; GO:0006626; GO:0032526 integral to mitochondrial outer membrane; mitochondrial fission; protein targeting to mitochondrion; response to retinoic acid IPR010987; IPR004045; IPR012336; Ganglioside-induced differentiation-associated protein 1 (GDAP1) GDAP1 Homo sapiens (Human) TR41349_c1_g2_i7 Q8TB36 GDAP1_HUMAN 2.00E-24 GO:0031307; GO:0000266; GO:0006626; GO:0032526 integral to mitochondrial outer membrane; mitochondrial fission; protein targeting to mitochondrion; response to retinoic acid IPR010987; IPR004045; IPR012336; Ganglioside-induced differentiation-associated protein 1 (GDAP1) GDAP1 Homo sapiens (Human) TR41351_c2_g1_i2 Q9NS93 TM7S3_HUMAN 4.00E-53 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR025256; Transmembrane 7 superfamily member 3 (Seven span transmembrane protein) TM7SF3 Homo sapiens (Human) TR41352_c1_g2_i1 A6QP15 HOT_BOVIN 0 GO:0047988; GO:0046872; GO:0005739; GO:0015993 hydroxyacid-oxoacid transhydrogenase activity; metal ion binding; mitochondrion; molecular hydrogen transport IPR001670; "Hydroxyacid-oxoacid transhydrogenase, mitochondrial (HOT) (EC 1.1.99.24) (Alcohol dehydrogenase iron-containing protein 1) (ADHFe1)" ADHFE1 Bos taurus (Bovine) TR41353_c0_g2_i1 Q6DDL7 UN93A_XENLA 9.00E-43 GO:0016021 integral to membrane IPR010291; IPR016196; Protein unc-93 homolog A (Unc-93A) unc93a Xenopus laevis (African clawed frog) TR41353_c0_g2_i2 Q710D3 UN93A_MOUSE 1.00E-38 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR010291; IPR016196; Protein unc-93 homolog A (Unc-93A) Unc93a Mus musculus (Mouse) TR41353_c0_g2_i3 Q5SPF7 UN93A_DANRE 6.00E-35 GO:0016021 integral to membrane IPR010291; IPR016196; Protein unc-93 homolog A (Unc-93A) unc93a si:dkey-14a7.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR41353_c0_g2_i4 Q6DDL7 UN93A_XENLA 1.00E-43 GO:0016021 integral to membrane IPR010291; IPR016196; Protein unc-93 homolog A (Unc-93A) unc93a Xenopus laevis (African clawed frog) TR41357_c1_g1_i1 Q96MM6 HS12B_HUMAN 9.00E-80 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR41357_c1_g1_i3 Q9VG58 HSP74_DROME 7.00E-10 GO:0005524; GO:0035080; GO:0005811; GO:0005875; GO:0001666 ATP binding; heat shock-mediated polytene chromosome puffing; lipid particle; microtubule associated complex; response to hypoxia IPR018181; IPR013126; Major heat shock 70 kDa protein Bbb (Heat shock protein 70Bbb) (HSP70-87C1) Hsp70Bbb CG5834 Drosophila melanogaster (Fruit fly) TR41358_c1_g1_i2 Q5ZL74 VAMP7_CHICK 2.00E-92 GO:0006888; GO:0005794; GO:0043001; GO:0031201; GO:0045177; GO:0017156; GO:0030054; GO:0005789; GO:0008333; GO:0043308; GO:0016021; GO:0031902; GO:0005765; GO:0043005; GO:0043312; GO:0048471; GO:0045335; GO:0030670; GO:0006911; GO:1900483; GO:0045202; GO:0030658; GO:0006906 "ER to Golgi vesicle-mediated transport; Golgi apparatus; Golgi to plasma membrane protein transport; SNARE complex; apical part of cell; calcium ion-dependent exocytosis; cell junction; endoplasmic reticulum membrane; endosome to lysosome transport; eosinophil degranulation; integral to membrane; late endosome membrane; lysosomal membrane; neuron projection; neutrophil degranulation; perinuclear region of cytoplasm; phagocytic vesicle; phagocytic vesicle membrane; phagocytosis, engulfment; regulation of protein targeting to vacuolar membrane; synapse; transport vesicle membrane; vesicle fusion" IPR011012; IPR010908; IPR001388; Vesicle-associated membrane protein 7 (Synaptobrevin-like protein 1) VAMP7 SYBL1 RCJMB04_7f19 Gallus gallus (Chicken) TR41358_c1_g1_i3 Q5ZL74 VAMP7_CHICK 7.00E-92 GO:0006888; GO:0005794; GO:0043001; GO:0031201; GO:0045177; GO:0017156; GO:0030054; GO:0005789; GO:0008333; GO:0043308; GO:0016021; GO:0031902; GO:0005765; GO:0043005; GO:0043312; GO:0048471; GO:0045335; GO:0030670; GO:0006911; GO:1900483; GO:0045202; GO:0030658; GO:0006906 "ER to Golgi vesicle-mediated transport; Golgi apparatus; Golgi to plasma membrane protein transport; SNARE complex; apical part of cell; calcium ion-dependent exocytosis; cell junction; endoplasmic reticulum membrane; endosome to lysosome transport; eosinophil degranulation; integral to membrane; late endosome membrane; lysosomal membrane; neuron projection; neutrophil degranulation; perinuclear region of cytoplasm; phagocytic vesicle; phagocytic vesicle membrane; phagocytosis, engulfment; regulation of protein targeting to vacuolar membrane; synapse; transport vesicle membrane; vesicle fusion" IPR011012; IPR010908; IPR001388; Vesicle-associated membrane protein 7 (Synaptobrevin-like protein 1) VAMP7 SYBL1 RCJMB04_7f19 Gallus gallus (Chicken) TR41358_c1_g1_i7 Q9LFP1 VA713_ARATH 2.00E-46 GO:0005794; GO:0016021; GO:0015031; GO:0009651; GO:0005774; GO:0016192 Golgi apparatus; integral to membrane; protein transport; response to salt stress; vacuolar membrane; vesicle-mediated transport IPR011012; IPR010908; IPR001388; Vesicle-associated membrane protein 713 (AtVAMP713) VAMP713 At5g11150 F2I11_40 Arabidopsis thaliana (Mouse-ear cress) TR41358_c1_g1_i8 Q86AQ7 VAM7B_DICDI 3.00E-50 GO:0005794; GO:0031201; GO:0000331; GO:0005789; GO:0008333; GO:0016021; GO:0031902; GO:0005765; GO:0030670; GO:0015031; GO:0030658; GO:0006906 Golgi apparatus; SNARE complex; contractile vacuole; endoplasmic reticulum membrane; endosome to lysosome transport; integral to membrane; late endosome membrane; lysosomal membrane; phagocytic vesicle membrane; protein transport; transport vesicle membrane; vesicle fusion IPR011012; IPR010908; IPR001388; Vesicle-associated membrane protein 7B vamp7B DDB_G0277173 Dictyostelium discoideum (Slime mold) TR41359_c0_g1_i1 Q8NE71 ABCF1_HUMAN 6.00E-56 GO:0005524; GO:0006200; GO:0016887; GO:0006954; GO:0005635; GO:0005654; GO:0042788; GO:0005840; GO:0043022; GO:0008494; GO:0008135; GO:0006413 "ATP binding; ATP catabolic process; ATPase activity; inflammatory response; nuclear envelope; nucleoplasm; polysomal ribosome; ribosome; ribosome binding; translation activator activity; translation factor activity, nucleic acid binding; translational initiation" IPR003593; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein) ABCF1 ABC50 Homo sapiens (Human) TR41359_c0_g2_i1 Q66H39 ABCF3_RAT 1.00E-130 GO:0005524; GO:0006200; GO:0016887; GO:0051607 ATP binding; ATP catabolic process; ATPase activity; defense response to virus IPR003593; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family F member 3 Abcf3 Rattus norvegicus (Rat) TR41361_c4_g1_i2 Q9CQ71 RFA3_MOUSE 8.00E-22 GO:0006310; GO:0006281; GO:0006260; GO:0005737; GO:0005654 DNA recombination; DNA repair; DNA replication; cytoplasm; nucleoplasm IPR012340; IPR013970; Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3) Rpa3 Mus musculus (Mouse) TR41362_c7_g6_i1 Q5RD58 CL004_PONAB 7.00E-147 IPR019311; Uncharacterized protein C12orf4 homolog Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41363_c0_g1_i10 Q69ZZ6 TMCC1_MOUSE 9.00E-83 GO:0016021 integral to membrane IPR019394; Transmembrane and coiled-coil domains protein 1 Tmcc1 Kiaa0779 Mus musculus (Mouse) TR41363_c0_g1_i2 Q69ZZ6 TMCC1_MOUSE 9.00E-81 GO:0016021 integral to membrane IPR019394; Transmembrane and coiled-coil domains protein 1 Tmcc1 Kiaa0779 Mus musculus (Mouse) TR41363_c0_g1_i3 Q9ULS5 TMCC3_HUMAN 3.00E-49 GO:0016021 integral to membrane IPR019394; Transmembrane and coiled-coil domains protein 3 TMCC3 KIAA1145 Homo sapiens (Human) TR41363_c0_g1_i8 Q69ZZ6 TMCC1_MOUSE 1.00E-81 GO:0016021 integral to membrane IPR019394; Transmembrane and coiled-coil domains protein 1 Tmcc1 Kiaa0779 Mus musculus (Mouse) TR41365_c0_g2_i2 Q9NUQ9 FA49B_HUMAN 1.00E-135 GO:0005929 cilium IPR009828; Protein FAM49B (L1) FAM49B BM-009 Homo sapiens (Human) TR41365_c0_g2_i4 Q9NUQ9 FA49B_HUMAN 1.00E-135 GO:0005929 cilium IPR009828; Protein FAM49B (L1) FAM49B BM-009 Homo sapiens (Human) TR41365_c0_g2_i5 Q9NUQ9 FA49B_HUMAN 1.00E-134 GO:0005929 cilium IPR009828; Protein FAM49B (L1) FAM49B BM-009 Homo sapiens (Human) TR41368_c0_g2_i1 Q5ZL91 INT7_CHICK 0 GO:0005694; GO:0005634; GO:0006974 chromosome; nucleus; response to DNA damage stimulus IPR011989; IPR016024; Integrator complex subunit 7 (Int7) INTS7 RCJMB04_7c6 Gallus gallus (Chicken) TR41370_c0_g1_i2 A8DYE2 TRPCG_DROME 7.00E-10 GO:0005261; GO:0034703; GO:0016049; GO:0070838; GO:0010960; GO:0046873; GO:0007005; GO:0055069 cation channel activity; cation channel complex; cell growth; divalent metal ion transport; magnesium ion homeostasis; metal ion transmembrane transporter activity; mitochondrion organization; zinc ion homeostasis IPR005821; Transient receptor potential cation channel trpm trpm CG44240 Drosophila melanogaster (Fruit fly) TR41370_c1_g1_i1 Q8CIR4 TRPM6_MOUSE 2.00E-10 GO:0005524; GO:0016324; GO:0031526; GO:0005262; GO:0005261; GO:0016021; GO:0046872; GO:0030001; GO:0004674; GO:0009636 ATP binding; apical plasma membrane; brush border membrane; calcium channel activity; cation channel activity; integral to membrane; metal ion binding; metal ion transport; protein serine/threonine kinase activity; response to toxic substance IPR005821; IPR011009; IPR004166; Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6) Trpm6 Mus musculus (Mouse) TR41370_c2_g1_i2 Q9BW91 NUDT9_HUMAN 1.00E-05 GO:0046032; GO:0047631; GO:0019144; GO:0046709; GO:0043262; GO:0005759; GO:0034656 ADP catabolic process; ADP-ribose diphosphatase activity; ADP-sugar diphosphatase activity; IDP catabolic process; adenosine-diphosphatase activity; mitochondrial matrix; nucleobase-containing small molecule catabolic process IPR000086; IPR015797; "ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9)" NUDT9 NUDT10 PSEC0099 UNQ3012/PRO9771 Homo sapiens (Human) TR41370_c2_g2_i2 Q5XIG0 NUDT9_RAT 4.00E-07 GO:0047631; GO:0005739 ADP-ribose diphosphatase activity; mitochondrion IPR000086; IPR015797; "ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9)" Nudt9 Rattus norvegicus (Rat) TR41370_c2_g5_i1 P34641 CED11_CAEEL 7.00E-40 GO:0006915; GO:0016021 apoptotic process; integral to membrane Protein ced-11 (Cell death protein 11) ced-11 ZK512.3 Caenorhabditis elegans TR41372_c0_g1_i1 Q14517 FAT1_HUMAN 4.00E-12 GO:0007015; GO:0009653; GO:0005509; GO:0016477; GO:0016337; GO:0005911; GO:0007267; GO:0007163; GO:0030175; GO:0007156; GO:0005887; GO:0030027; GO:0005634; GO:0048471 Q8N8S7; Q9NSC5; Q99JP6 actin filament organization; anatomical structure morphogenesis; calcium ion binding; cell migration; cell-cell adhesion; cell-cell junction; cell-cell signaling; establishment or maintenance of cell polarity; filopodium; homophilic cell adhesion; integral to plasma membrane; lamellipodium; nucleus; perinuclear region of cytoplasm IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) TR41372_c0_g2_i1 Q8BNA6 FAT3_MOUSE 2.00E-10 GO:0005509; GO:0007156; GO:0016021; GO:0007275; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; multicellular organismal development; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Protocadherin Fat 3 (FAT tumor suppressor homolog 3) Fat3 Gm1132 Gm510 Mus musculus (Mouse) TR41372_c2_g1_i1 Q6NZL8 SCUB1_MOUSE 4.00E-13 GO:0005509; GO:0009897; GO:0005615; GO:0019897; GO:0046982; GO:0051260 calcium ion binding; external side of plasma membrane; extracellular space; extrinsic to plasma membrane; protein heterodimerization activity; protein homooligomerization IPR026823; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR009030; IPR011641; "Signal peptide, CUB and EGF-like domain-containing protein 1" Scube1 Mus musculus (Mouse) TR41372_c4_g1_i1 P0C6B8 SVEP1_RAT 2.00E-10 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) TR41372_c4_g1_i3 P0C6B8 SVEP1_RAT 2.00E-10 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) TR41372_c4_g2_i1 A2AVA0 SVEP1_MOUSE 9.00E-13 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)" Svep1 Mus musculus (Mouse) TR41372_c4_g2_i2 Q6NZL8 SCUB1_MOUSE 2.00E-12 GO:0005509; GO:0009897; GO:0005615; GO:0019897; GO:0046982; GO:0051260 calcium ion binding; external side of plasma membrane; extracellular space; extrinsic to plasma membrane; protein heterodimerization activity; protein homooligomerization IPR026823; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR009030; IPR011641; "Signal peptide, CUB and EGF-like domain-containing protein 1" Scube1 Mus musculus (Mouse) TR41373_c0_g1_i1 B0R1D5 SZ12B_DANRE 1.00E-177 GO:0035098; GO:0016568; GO:0046872; GO:0006355; GO:0006351 "ESC/E(Z) complex; chromatin modification; metal ion binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019135; IPR015880; Polycomb protein suz12-B (Suppressor of zeste 12 protein homolog B) suz12b suz12 si:dkey-10p5.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR41373_c0_g1_i4 Q0VA03 SUZ12_XENTR 4.00E-177 GO:0035098; GO:0016568; GO:0046872; GO:0006355; GO:0006351 "ESC/E(Z) complex; chromatin modification; metal ion binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019135; IPR015880; Polycomb protein suz12 (Suppressor of zeste 12 protein homolog) suz12 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41373_c0_g1_i5 Q0VA03 SUZ12_XENTR 3.00E-177 GO:0035098; GO:0016568; GO:0046872; GO:0006355; GO:0006351 "ESC/E(Z) complex; chromatin modification; metal ion binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR019135; IPR015880; Polycomb protein suz12 (Suppressor of zeste 12 protein homolog) suz12 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41374_c5_g1_i2 Q25637 PER_PERAM 1.00E-48 GO:0005634; GO:0006355; GO:0048511; GO:0004871 "nucleus; regulation of transcription, DNA-dependent; rhythmic process; signal transducer activity" IPR001610; IPR000014; IPR013767; Period circadian protein per Periplaneta americana (American cockroach) (Blatta americana) TR41374_c5_g1_i3 O54943 PER2_MOUSE 8.00E-34 GO:0007623; GO:0005829; GO:0000122; GO:0005654; GO:0048471; GO:0000988; GO:0004871; GO:0006351 Q9WTL8; O08785; P97784; Q9R194; Q91VJ2 "circadian rhythm; cytosol; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; perinuclear region of cytoplasm; protein binding transcription factor activity; signal transducer activity; transcription, DNA-dependent" IPR001610; IPR000014; IPR013655; IPR022728; Period circadian protein homolog 2 (mPER2) (Circadian clock protein PERIOD 2) Per2 Mus musculus (Mouse) TR41374_c5_g1_i4 Q25637 PER_PERAM 3.00E-48 GO:0005634; GO:0006355; GO:0048511; GO:0004871 "nucleus; regulation of transcription, DNA-dependent; rhythmic process; signal transducer activity" IPR001610; IPR000014; IPR013767; Period circadian protein per Periplaneta americana (American cockroach) (Blatta americana) TR41376_c2_g1_i2 Q5ZJF3 TAD2A_CHICK 6.00E-28 GO:0003677; GO:0003682; GO:0005694; GO:0005634; GO:0006355; GO:0006351 "DNA binding; chromatin binding; chromosome; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009057; IPR001005; IPR017884; IPR007526; IPR016827; Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) (ADA2-like protein) TADA2A TADA2L RCJMB04_18k17 Gallus gallus (Chicken) TR41376_c2_g1_i3 Q9CQ48 NUDC2_MOUSE 2.00E-56 GO:0000777; GO:0005737; GO:0005815; GO:0000922 condensed chromosome kinetochore; cytoplasm; microtubule organizing center; spindle pole IPR007052; IPR008978; IPR027763; NudC domain-containing protein 2 Nudcd2 D11Ertd603e Mus musculus (Mouse) TR41376_c2_g1_i7 Q9CQ48 NUDC2_MOUSE 2.00E-56 GO:0000777; GO:0005737; GO:0005815; GO:0000922 condensed chromosome kinetochore; cytoplasm; microtubule organizing center; spindle pole IPR007052; IPR008978; IPR027763; NudC domain-containing protein 2 Nudcd2 D11Ertd603e Mus musculus (Mouse) TR41376_c2_g1_i8 Q9SFD5 TAD2A_ARATH 6.00E-16 GO:0003677; GO:0003682; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "DNA binding; chromatin binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR009057; IPR001005; IPR017884; IPR007526; IPR016827; IPR000433; Transcriptional adapter ADA2a (AtADA2a) ADA2A HAC10 HXA02 HXA2 At3g07740 F17A17.8 MLP3.19 Arabidopsis thaliana (Mouse-ear cress) TR41376_c2_g2_i2 Q3SZP8 TAD2A_BOVIN 4.00E-82 GO:0005671; GO:0003677; GO:0000125; GO:0003682; GO:0005694; GO:0043966; GO:0004402; GO:0007067; GO:0072686; GO:0031063; GO:0001932; GO:0031647; GO:0006355; GO:0090043; GO:0006351; GO:0008270 "Ada2/Gcn5/Ada3 transcription activator complex; DNA binding; PCAF complex; chromatin binding; chromosome; histone H3 acetylation; histone acetyltransferase activity; mitosis; mitotic spindle; regulation of histone deacetylation; regulation of protein phosphorylation; regulation of protein stability; regulation of transcription, DNA-dependent; regulation of tubulin deacetylation; transcription, DNA-dependent; zinc ion binding" IPR009057; IPR001005; IPR017884; IPR007526; IPR016827; IPR000433; Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) (ADA2-like protein) TADA2A TADA2L Bos taurus (Bovine) TR41376_c2_g2_i3 Q7KSD8 TAD2A_DROME 2.00E-32 GO:0005671; GO:0003677; GO:0003682; GO:0006338; GO:0043966; GO:0043967; GO:0042789; GO:0006355; GO:0035327; GO:0008270 O76216 "Ada2/Gcn5/Ada3 transcription activator complex; DNA binding; chromatin binding; chromatin remodeling; histone H3 acetylation; histone H4 acetylation; mRNA transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcriptionally active chromatin; zinc ion binding" IPR009057; IPR017877; IPR001005; IPR007526; IPR016827; IPR000433; Transcriptional adapter 2A (dADA2a) Rpb4 Ada2a CG33520 Drosophila melanogaster (Fruit fly) TR41377_c4_g1_i1 Q96M20 CT152_HUMAN 4.00E-08 IPR018490; IPR018488; IPR000595; IPR014710; Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) TR41377_c7_g2_i1 Q9H305 LITFL_HUMAN 6.00E-13 GO:0042771; GO:0005634; GO:0033209 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; nucleus; tumor necrosis factor-mediated signaling pathway IPR006629; Cell death-inducing p53-target protein 1 (Cell death involved p53-target) (Cell death-inducing protein) (LITAF-like protein) (Lipopolysaccharide-induced tumor necrosis factor-alpha-like protein) (Transmembrane protein I1) CDIP1 C16orf5 CDIP LITAFL Homo sapiens (Human) TR41378_c3_g1_i6 P14350 POL_FOAMV 2.00E-07 GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0075713; GO:0030430; GO:0042025; GO:0046872; GO:0090305; GO:0006508; GO:0004523; GO:0046718; GO:0075732; GO:0019012 DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; establishment of integrated proviral latency; host cell cytoplasm; host cell nucleus; metal ion binding; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; viral entry into host cell; viral penetration into host nucleus; virion IPR001584; IPR012337; IPR002156; IPR000477; IPR001641; Pro-Pol polyprotein (Pr125Pol) [Cleaved into: Protease/Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (EC 3.4.23.-) (p87Pro-RT-RNaseH); Protease/Reverse transcriptase (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.4.23.-) (p65Pro-RT); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN) (p42In)] pol Human spumaretrovirus (SFVcpz(hu)) (Human foamy virus) TR41379_c1_g1_i1 Q9NRP7 STK36_HUMAN 2.00E-107 GO:0005524; GO:0007420; GO:0042384; GO:0005737; GO:0003351; GO:0000287; GO:0005634; GO:0007228; GO:0045880; GO:0009791; GO:0004674; GO:0008134 Q9UMX1 ATP binding; brain development; cilium assembly; cytoplasm; epithelial cilium movement; magnesium ion binding; nucleus; positive regulation of hh target transcription factor activity; positive regulation of smoothened signaling pathway; post-embryonic development; protein serine/threonine kinase activity; transcription factor binding IPR011989; IPR016024; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog) STK36 KIAA1278 Homo sapiens (Human) TR41379_c2_g1_i1 Q69ZM6 STK36_MOUSE 7.00E-100 GO:0005524; GO:0007420; GO:0042384; GO:0005737; GO:0003351; GO:0046872; GO:0005634; GO:0007228; GO:0045880; GO:0009791; GO:0004674; GO:0008134 ATP binding; brain development; cilium assembly; cytoplasm; epithelial cilium movement; metal ion binding; nucleus; positive regulation of hh target transcription factor activity; positive regulation of smoothened signaling pathway; post-embryonic development; protein serine/threonine kinase activity; transcription factor binding IPR011989; IPR016024; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog) Stk36 Kiaa1278 Mus musculus (Mouse) TR41379_c2_g1_i2 Q69ZM6 STK36_MOUSE 2.00E-34 GO:0005524; GO:0007420; GO:0042384; GO:0005737; GO:0003351; GO:0046872; GO:0005634; GO:0007228; GO:0045880; GO:0009791; GO:0004674; GO:0008134 ATP binding; brain development; cilium assembly; cytoplasm; epithelial cilium movement; metal ion binding; nucleus; positive regulation of hh target transcription factor activity; positive regulation of smoothened signaling pathway; post-embryonic development; protein serine/threonine kinase activity; transcription factor binding IPR011989; IPR016024; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog) Stk36 Kiaa1278 Mus musculus (Mouse) TR41379_c3_g1_i1 Q2QAV0 TIO_ARATH 4.00E-06 GO:0005524; GO:0000911; GO:0005856; GO:0009558; GO:0009524; GO:0004674 Q9LDN0 ATP binding; cytokinesis by cell plate formation; cytoskeleton; embryo sac cellularization; phragmoplast; protein serine/threonine kinase activity IPR011989; IPR016024; IPR000225; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase TIO (EC 2.7.11.1) (Fused homolog) (AtFUSED) (Protein TWO-IN-ONE) (AtTIO) TIO FU At1g50240 At1g50230 F14I3.15 Arabidopsis thaliana (Mouse-ear cress) TR41380_c1_g1_i10 Q4V7T7 T15BA_XENLA 2.00E-09 GO:0016021 integral to membrane IPR027315; IPR019402; Transmembrane protein 150B-A (Transmembrane protein 224-A) tmem150b-a tmem224-a Xenopus laevis (African clawed frog) TR41380_c1_g1_i5 Q9CR48 DRAM2_MOUSE 1.00E-56 GO:0005794; GO:0030262; GO:0097194; GO:0016021; GO:0005765; GO:0005764 Golgi apparatus; apoptotic nuclear changes; execution phase of apoptosis; integral to membrane; lysosomal membrane; lysosome IPR027315; IPR019402; DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77) Dram2 Tmem77 Mus musculus (Mouse) TR41380_c1_g1_i7 Q4V7T7 T15BA_XENLA 2.00E-22 GO:0016021 integral to membrane IPR027315; IPR019402; Transmembrane protein 150B-A (Transmembrane protein 224-A) tmem150b-a tmem224-a Xenopus laevis (African clawed frog) TR41380_c1_g1_i9 Q5BK09 DRAM2_RAT 2.00E-19 GO:0097194; GO:0016021; GO:0005765; GO:0005764 execution phase of apoptosis; integral to membrane; lysosomal membrane; lysosome IPR027315; IPR019402; DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77) Dram2 Tmem77 Rattus norvegicus (Rat) TR41382_c0_g1_i1 Q5NBX1 COBL_MOUSE 2.00E-11 GO:0051764; GO:0051639; GO:0030041; GO:0003785; GO:0044295; GO:0005938; GO:0048669; GO:0005856; GO:0044294; GO:0048565; GO:0000578; GO:0033504; GO:0001889; GO:0001843; GO:0043025; GO:0030903; GO:0048471; GO:0005886; GO:1900006; GO:0001726; GO:0001757 Q9Z0W5; Q9QY17; Q5I2Z0 actin crosslink formation; actin filament network formation; actin filament polymerization; actin monomer binding; axonal growth cone; cell cortex; collateral sprouting in absence of injury; cytoskeleton; dendritic growth cone; digestive tract development; embryonic axis specification; floor plate development; liver development; neural tube closure; neuronal cell body; notochord development; perinuclear region of cytoplasm; plasma membrane; positive regulation of dendrite development; ruffle; somite specification IPR019025; IPR003124; Protein cordon-bleu Cobl Kiaa0633 Mus musculus (Mouse) TR41382_c0_g1_i2 Q53SF7 COBL1_HUMAN 4.00E-14 IPR019025; IPR003124; Cordon-bleu protein-like 1 COBLL1 KIAA0977 Homo sapiens (Human) TR41382_c0_g1_i3 Q53SF7 COBL1_HUMAN 4.00E-14 IPR019025; IPR003124; Cordon-bleu protein-like 1 COBLL1 KIAA0977 Homo sapiens (Human) TR41382_c0_g1_i7 Q5NBX1 COBL_MOUSE 6.00E-11 GO:0051764; GO:0051639; GO:0030041; GO:0003785; GO:0044295; GO:0005938; GO:0048669; GO:0005856; GO:0044294; GO:0048565; GO:0000578; GO:0033504; GO:0001889; GO:0001843; GO:0043025; GO:0030903; GO:0048471; GO:0005886; GO:1900006; GO:0001726; GO:0001757 Q9Z0W5; Q9QY17; Q5I2Z0 actin crosslink formation; actin filament network formation; actin filament polymerization; actin monomer binding; axonal growth cone; cell cortex; collateral sprouting in absence of injury; cytoskeleton; dendritic growth cone; digestive tract development; embryonic axis specification; floor plate development; liver development; neural tube closure; neuronal cell body; notochord development; perinuclear region of cytoplasm; plasma membrane; positive regulation of dendrite development; ruffle; somite specification IPR019025; IPR003124; Protein cordon-bleu Cobl Kiaa0633 Mus musculus (Mouse) TR41383_c2_g4_i2 Q9H5I5 PIEZ2_HUMAN 2.00E-13 GO:0005261; GO:0006812; GO:0016021; GO:0008381; GO:0042391 cation channel activity; cation transport; integral to membrane; mechanically-gated ion channel activity; regulation of membrane potential IPR027272; Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) PIEZO2 C18orf30 C18orf58 FAM38B Homo sapiens (Human) TR41388_c3_g1_i1 P81601 ADHL_GADMO 1.00E-136 GO:0051903; GO:0004022; GO:0005737; GO:0006069; GO:0008270 S-(hydroxymethyl)glutathione dehydrogenase activity; alcohol dehydrogenase (NAD) activity; cytoplasm; ethanol oxidation; zinc ion binding IPR014183; IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; Alcohol dehydrogenase class-3 chain L (EC 1.1.1.1) (Alcohol dehydrogenase class-III chain L) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) Gadus morhua (Atlantic cod) TR41389_c2_g1_i1 Q9UJ70 NAGK_HUMAN 9.00E-65 GO:0005524; GO:0045127; GO:0006044; GO:0006051; GO:0019262; GO:0009384 Q9UI36; Q8TBB1 ATP binding; N-acetylglucosamine kinase activity; N-acetylglucosamine metabolic process; N-acetylmannosamine metabolic process; N-acetylneuraminate catabolic process; N-acylmannosamine kinase activity IPR002731; Amino-sugar metabolism; N-acetylneuraminate degradation. N-acetyl-D-glucosamine kinase (N-acetylglucosamine kinase) (EC 2.7.1.59) (GlcNAc kinase) NAGK Homo sapiens (Human) TR41390_c1_g1_i1 P17972 KCNAW_DROME 9.00E-48 GO:0005251; GO:0051260; GO:0030431; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; sleep; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR015572; IPR003131; IPR028325; Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) TR41390_c1_g1_i2 O18868 KCNB1_PIG 3.00E-40 GO:0051260; GO:0005249; GO:0008076 protein homooligomerization; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003973; IPR004350; IPR003131; IPR028325; Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1) KCNB1 Sus scrofa (Pig) TR41391_c4_g1_i1 Q95029 CATL_DROME 3.00E-53 GO:0008234; GO:0007586; GO:0045169; GO:0005764; GO:0006508; GO:0035071 cysteine-type peptidase activity; digestion; fusome; lysosome; proteolysis; salivary gland cell autophagic cell death IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L (EC 3.4.22.15) (Cysteine proteinase 1) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] Cp1 fs(2)50Ca CG6692 Drosophila melanogaster (Fruit fly) TR41391_c4_g1_i11 P05993 PAPA5_CARPA 1.00E-07 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR025661; IPR025660; IPR013128; IPR000668; Cysteine proteinase (EC 3.4.22.-) (Clone PLBPC13) (Fragment) Carica papaya (Papaya) TR41391_c4_g1_i13 P12399 CTL2A_MOUSE 1.00E-13 GO:0008234; GO:0030425; GO:0005576; GO:0050728; GO:0010955; GO:0045589 cysteine-type peptidase activity; dendrite; extracellular region; negative regulation of inflammatory response; negative regulation of protein processing; regulation of regulatory T cell differentiation IPR013128; IPR013201; Protein CTLA-2-alpha (Cytotoxic T-lymphocyte-associated protein 2-alpha) Ctla2a Mus musculus (Mouse) TR41391_c4_g1_i2 P32956 CYSP3_CARCN 3.00E-10 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR000169; IPR013128; IPR000668; Cysteine proteinase 3 (EC 3.4.22.-) (CC-III) (Cysteine proteinase III) (Fragment) Carica candamarcensis (Mountain papaya) (Vasconcellea cundinamarcensis) TR41391_c4_g1_i3 Q95029 CATL_DROME 4.00E-99 GO:0008234; GO:0007586; GO:0045169; GO:0005764; GO:0006508; GO:0035071 cysteine-type peptidase activity; digestion; fusome; lysosome; proteolysis; salivary gland cell autophagic cell death IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L (EC 3.4.22.15) (Cysteine proteinase 1) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] Cp1 fs(2)50Ca CG6692 Drosophila melanogaster (Fruit fly) TR41391_c4_g1_i7 P32957 CYSP4_CARCN 4.00E-11 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR000169; IPR013128; IPR000668; Cysteine proteinase 4 (EC 3.4.22.-) (CC-IV) (Cysteine proteinase IV) (Fragment) Carica candamarcensis (Mountain papaya) (Vasconcellea cundinamarcensis) TR41392_c0_g2_i2 Q7ZTY4 RBBP7_DANRE 0 GO:0006260; GO:0035098; GO:0016568; GO:0006355; GO:0006351 "DNA replication; ESC/E(Z) complex; chromatin modification; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR020472; IPR022052; IPR015943; IPR001680; IPR019775; IPR017986; Histone-binding protein RBBP7 (Retinoblastoma-binding protein 7) (RBBP-7) rbbp7 rbb4l Danio rerio (Zebrafish) (Brachydanio rerio) TR41392_c0_g2_i3 Q24572 CAF1_DROME 0 GO:0033186; GO:0006281; GO:0035098; GO:0031523; GO:0016589; GO:0016581; GO:0070822; GO:0006342; GO:0048813; GO:0007307; GO:0070734; GO:0051567; GO:0016573; GO:0035035; GO:0042393; GO:0042826; GO:0007517; GO:0000122; GO:0006334; GO:0042766; GO:0016584; GO:0005700; GO:0008284; GO:0007346; GO:0007379; GO:0005667; GO:0006351 P42124; Q24338; Q94517 "CAF-1 complex; DNA repair; ESC/E(Z) complex; Myb complex; NURF complex; NuRD complex; Sin3-type complex; chromatin silencing; dendrite morphogenesis; eggshell chorion gene amplification; histone H3-K27 methylation; histone H3-K9 methylation; histone acetylation; histone acetyltransferase binding; histone binding; histone deacetylase binding; muscle organ development; negative regulation of transcription from RNA polymerase II promoter; nucleosome assembly; nucleosome mobilization; nucleosome positioning; polytene chromosome; positive regulation of cell proliferation; regulation of mitotic cell cycle; segment specification; transcription factor complex; transcription, DNA-dependent" IPR020472; IPR022052; IPR015943; IPR001680; IPR019775; IPR017986; Probable histone-binding protein Caf1 (Chromatin assembly factor 1 p55 subunit) (CAF-1 p55 subunit) (Nucleosome-remodeling factor 55 kDa subunit) (NURF-55) (dCAF-1) Caf1 CG4236 Drosophila melanogaster (Fruit fly) TR41393_c2_g1_i1 Q8VBV4 FBXW7_MOUSE 1.00E-55 GO:0005794; GO:0007219; GO:0019005; GO:0031146; GO:0005783; GO:0030324; GO:0005634; GO:0048471; GO:0016567; GO:0003700; GO:0001570 Golgi apparatus; Notch signaling pathway; SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; endoplasmic reticulum; lung development; nucleus; perinuclear region of cytoplasm; protein ubiquitination; sequence-specific DNA binding transcription factor activity; vasculogenesis IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10) Fbxw7 Fbw7 Fbwd6 Fbxw6 Mus musculus (Mouse) TR41393_c2_g1_i2 Q5SRY7 FBW1B_MOUSE 0 GO:0019005; GO:0031146; GO:0016055; GO:0007049; GO:0005813; GO:0005829; GO:0042347; GO:0045892; GO:0005634; GO:0042753; GO:0045862; GO:0045893; GO:0006470; GO:0031648; GO:0000209; GO:0048511; GO:0004842 "SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway; cell cycle; centrosome; cytosol; negative regulation of NF-kappaB import into nucleus; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of circadian rhythm; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; protein dephosphorylation; protein destabilization; protein polyubiquitination; rhythmic process; ubiquitin-protein ligase activity" IPR021977; IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS) Fbxw11 Btrcp2 Fbw1b Fbxw1b Mus musculus (Mouse) TR41393_c2_g1_i3 Q9Y297 FBW1A_HUMAN 0 GO:0019005; GO:0016055; GO:0031145; GO:0060444; GO:0071407; GO:0005829; GO:0016874; GO:0033598; GO:0019048; GO:0043433; GO:0045879; GO:0045892; GO:0005634; GO:0042753; GO:0045862; GO:0045893; GO:0051437; GO:0006470; GO:0031648; GO:0000209; GO:0016567; GO:0043122; GO:0051726; GO:0061136; GO:0007165; GO:0016032 P35222; Q13616; Q00987; Q15843; P63208; O95863; P30291 "SCF ubiquitin ligase complex; Wnt receptor signaling pathway; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; branching involved in mammary gland duct morphogenesis; cellular response to organic cyclic compound; cytosol; ligase activity; mammary gland epithelial cell proliferation; modulation by virus of host morphology or physiology; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of smoothened signaling pathway; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of circadian rhythm; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; protein dephosphorylation; protein destabilization; protein polyubiquitination; protein ubiquitination; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of cell cycle; regulation of proteasomal protein catabolic process; signal transduction; viral process" IPR021977; IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit) BTRC BTRCP FBW1A FBXW1A Homo sapiens (Human) TR41393_c2_g1_i4 Q9Y297 FBW1A_HUMAN 0 GO:0019005; GO:0016055; GO:0031145; GO:0060444; GO:0071407; GO:0005829; GO:0016874; GO:0033598; GO:0019048; GO:0043433; GO:0045879; GO:0045892; GO:0005634; GO:0042753; GO:0045862; GO:0045893; GO:0051437; GO:0006470; GO:0031648; GO:0000209; GO:0016567; GO:0043122; GO:0051726; GO:0061136; GO:0007165; GO:0016032 P35222; Q13616; Q00987; Q15843; P63208; O95863; P30291 "SCF ubiquitin ligase complex; Wnt receptor signaling pathway; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; branching involved in mammary gland duct morphogenesis; cellular response to organic cyclic compound; cytosol; ligase activity; mammary gland epithelial cell proliferation; modulation by virus of host morphology or physiology; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of smoothened signaling pathway; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of circadian rhythm; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; protein dephosphorylation; protein destabilization; protein polyubiquitination; protein ubiquitination; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of cell cycle; regulation of proteasomal protein catabolic process; signal transduction; viral process" IPR021977; IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit) BTRC BTRCP FBW1A FBXW1A Homo sapiens (Human) TR41394_c0_g1_i10 Q18439 NAS8_CAEEL 3.00E-27 GO:0005576; GO:0004222; GO:0006508; GO:0008270 extracellular region; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR001506; IPR017367; IPR006026; IPR003582; Zinc metalloproteinase nas-8 (EC 3.4.24.21) (Nematode astacin 8) nas-8 C34D4.9 Caenorhabditis elegans TR41394_c0_g1_i2 Q18439 NAS8_CAEEL 4.00E-27 GO:0005576; GO:0004222; GO:0006508; GO:0008270 extracellular region; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR001506; IPR017367; IPR006026; IPR003582; Zinc metalloproteinase nas-8 (EC 3.4.24.21) (Nematode astacin 8) nas-8 C34D4.9 Caenorhabditis elegans TR41394_c0_g1_i3 P98068 SPAN_STRPU 7.00E-48 GO:0004222; GO:0007275; GO:0006508; GO:0008270 metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR000859; IPR000742; IPR013032; IPR024079; IPR001506; IPR006026; IPR017369; Protein SpAN (EC 3.4.24.-) SPAN Strongylocentrotus purpuratus (Purple sea urchin) TR41394_c0_g1_i4 P98068 SPAN_STRPU 6.00E-48 GO:0004222; GO:0007275; GO:0006508; GO:0008270 metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR000859; IPR000742; IPR013032; IPR024079; IPR001506; IPR006026; IPR017369; Protein SpAN (EC 3.4.24.-) SPAN Strongylocentrotus purpuratus (Purple sea urchin) TR41394_c0_g1_i6 Q93243 NAS37_CAEEL 1.00E-31 GO:0040002; GO:0042395; GO:0005576; GO:0004222; GO:0006508; GO:0008270 "collagen and cuticulin-based cuticle development; ecdysis, collagen and cuticulin-based cuticle; extracellular region; metalloendopeptidase activity; proteolysis; zinc ion binding" IPR000859; IPR000742; IPR013032; IPR024079; IPR001506; IPR017050; IPR006026; IPR000884; Zinc metalloproteinase nas-37 (EC 3.4.24.21) (Nematode astacin 37) nas-37 C17G1.6 Caenorhabditis elegans TR41394_c0_g1_i9 Q91641 THIB_XENLA 1.00E-09 GO:0005615; GO:0016020; GO:0007275 extracellular space; membrane; multicellular organismal development IPR008985; IPR000998; Thyroid hormone-induced protein B Xenopus laevis (African clawed frog) TR41395_c0_g2_i1 Q5R9T5 SPTC1_PONAB 0 GO:0035339; GO:0009058; GO:0016021; GO:0030170; GO:0004758; GO:0006665 SPOTS complex; biosynthetic process; integral to membrane; pyridoxal phosphate binding; serine C-palmitoyltransferase activity; sphingolipid metabolic process IPR004839; IPR015424; IPR015421; IPR015422; Lipid metabolism; sphingolipid metabolism. Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1) SPTLC1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41395_c0_g2_i5 Q7VL09 BIKB_HAEDU 3.00E-21 GO:0008710; GO:0009102; GO:0030170 8-amino-7-oxononanoate synthase activity; biotin biosynthetic process; pyridoxal phosphate binding IPR001917; IPR004839; IPR015424; IPR015421; IPR015422; Cofactor biosynthesis; biotin biosynthesis. 8-amino-7-oxononanoate synthase (AONS) (EC 2.3.1.47) (7-keto-8-amino-pelargonic acid synthase) (7-KAP synthase) (KAPA synthase) (8-amino-7-ketopelargonate synthase) (Alpha-oxoamine synthase) HD_1684 Haemophilus ducreyi (strain 35000HP / ATCC 700724) TR41395_c0_g2_i7 Q5R9T5 SPTC1_PONAB 0 GO:0035339; GO:0009058; GO:0016021; GO:0030170; GO:0004758; GO:0006665 SPOTS complex; biosynthetic process; integral to membrane; pyridoxal phosphate binding; serine C-palmitoyltransferase activity; sphingolipid metabolic process IPR004839; IPR015424; IPR015421; IPR015422; Lipid metabolism; sphingolipid metabolism. Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1) SPTLC1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41397_c4_g3_i4 Q8K0U4 HS12A_MOUSE 4.00E-46 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR41397_c4_g3_i5 Q8K0U4 HS12A_MOUSE 6.00E-46 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR41398_c1_g1_i3 Q8BQZ4 RLGPB_MOUSE 4.00E-73 GO:0017123; GO:0032484; GO:0032859; GO:0005829; GO:0046982; GO:0060178 Ral GTPase activator activity; Ral protein signal transduction; activation of Ral GTPase activity; cytosol; protein heterodimerization activity; regulation of exocyst localization IPR000331; Ral GTPase-activating protein subunit beta (p170) Ralgapb Kiaa1219 Mus musculus (Mouse) TR41398_c1_g1_i6 Q8BQZ4 RLGPB_MOUSE 3.00E-73 GO:0017123; GO:0032484; GO:0032859; GO:0005829; GO:0046982; GO:0060178 Ral GTPase activator activity; Ral protein signal transduction; activation of Ral GTPase activity; cytosol; protein heterodimerization activity; regulation of exocyst localization IPR000331; Ral GTPase-activating protein subunit beta (p170) Ralgapb Kiaa1219 Mus musculus (Mouse) TR41400_c1_g1_i2 Q4P8R9 PABP_USTMA 2.00E-07 GO:0003723; GO:0005737; GO:0006397; GO:0051028; GO:0000166; GO:0005634; GO:0006417 RNA binding; cytoplasm; mRNA processing; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR012677; IPR006515; IPR002004; IPR000504; "Polyadenylate-binding protein, cytoplasmic and nuclear (PABP) (Poly(A)-binding protein) (Polyadenylate tail-binding protein)" PAB1 UM03494 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR41400_c2_g4_i2 Q9ZQA8 PABPX_ARATH 4.00E-10 GO:0003723; GO:0005737; GO:0000166; GO:0005634; GO:0006417 RNA binding; cytoplasm; nucleotide binding; nucleus; regulation of translation IPR012677; IPR006515; IPR002004; IPR000504; Polyadenylate-binding protein 7 (PABP-7) (Poly(A)-binding protein 7) PAB7 At2g36660 F13K3.6 Arabidopsis thaliana (Mouse-ear cress) TR41400_c2_g4_i3 Q8R3C6 RBM19_MOUSE 4.00E-158 GO:0003723; GO:0005694; GO:0005737; GO:0007275; GO:0005730; GO:0005654; GO:0000166; GO:0040019 RNA binding; chromosome; cytoplasm; multicellular organismal development; nucleolus; nucleoplasm; nucleotide binding; positive regulation of embryonic development IPR012677; IPR000504; Probable RNA-binding protein 19 (RNA-binding motif protein 19) Rbm19 Mus musculus (Mouse) TR41400_c2_g4_i4 Q8R3C6 RBM19_MOUSE 5.00E-158 GO:0003723; GO:0005694; GO:0005737; GO:0007275; GO:0005730; GO:0005654; GO:0000166; GO:0040019 RNA binding; chromosome; cytoplasm; multicellular organismal development; nucleolus; nucleoplasm; nucleotide binding; positive regulation of embryonic development IPR012677; IPR000504; Probable RNA-binding protein 19 (RNA-binding motif protein 19) Rbm19 Mus musculus (Mouse) TR41402_c1_g4_i10 P97300 NPTN_MOUSE 1.00E-06 GO:0050839; GO:0007204; GO:0007156; GO:0016021; GO:0060291; GO:0045743; GO:0048170; GO:0010976; GO:0001934; GO:0042734; GO:0005105 cell adhesion molecule binding; elevation of cytosolic calcium ion concentration; homophilic cell adhesion; integral to membrane; long-term synaptic potentiation; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of long-term neuronal synaptic plasticity; positive regulation of neuron projection development; positive regulation of protein phosphorylation; presynaptic membrane; type 1 fibroblast growth factor receptor binding IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR027112; Neuroplastin (Stromal cell-derived receptor 1) (SDR-1) Nptn Sdfr1 Sdr1 Mus musculus (Mouse) TR41402_c1_g4_i15 P97300 NPTN_MOUSE 1.00E-06 GO:0050839; GO:0007204; GO:0007156; GO:0016021; GO:0060291; GO:0045743; GO:0048170; GO:0010976; GO:0001934; GO:0042734; GO:0005105 cell adhesion molecule binding; elevation of cytosolic calcium ion concentration; homophilic cell adhesion; integral to membrane; long-term synaptic potentiation; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of long-term neuronal synaptic plasticity; positive regulation of neuron projection development; positive regulation of protein phosphorylation; presynaptic membrane; type 1 fibroblast growth factor receptor binding IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR027112; Neuroplastin (Stromal cell-derived receptor 1) (SDR-1) Nptn Sdfr1 Sdr1 Mus musculus (Mouse) TR41402_c1_g4_i2 P97300 NPTN_MOUSE 1.00E-06 GO:0050839; GO:0007204; GO:0007156; GO:0016021; GO:0060291; GO:0045743; GO:0048170; GO:0010976; GO:0001934; GO:0042734; GO:0005105 cell adhesion molecule binding; elevation of cytosolic calcium ion concentration; homophilic cell adhesion; integral to membrane; long-term synaptic potentiation; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of long-term neuronal synaptic plasticity; positive regulation of neuron projection development; positive regulation of protein phosphorylation; presynaptic membrane; type 1 fibroblast growth factor receptor binding IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR027112; Neuroplastin (Stromal cell-derived receptor 1) (SDR-1) Nptn Sdfr1 Sdr1 Mus musculus (Mouse) TR41402_c1_g4_i3 Q99PA3 BASI_CRIGR 2.00E-07 GO:0016021; GO:0005537; GO:0042470; GO:0005886 integral to membrane; mannose binding; melanosome; plasma membrane IPR009151; IPR007110; IPR013783; IPR013098; IPR003599; Basigin (CD antigen CD147) (Fragment) BSG Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR41402_c1_g4_i4 Q28740 BASI_RABIT 2.00E-06 GO:0016021; GO:0005537; GO:0042470; GO:0005886 integral to membrane; mannose binding; melanosome; plasma membrane IPR009151; IPR007110; IPR013783; IPR013098; IPR003599; Basigin (CD antigen CD147) BSG Oryctolagus cuniculus (Rabbit) TR41402_c1_g4_i5 P97300 NPTN_MOUSE 2.00E-07 GO:0050839; GO:0007204; GO:0007156; GO:0016021; GO:0060291; GO:0045743; GO:0048170; GO:0010976; GO:0001934; GO:0042734; GO:0005105 cell adhesion molecule binding; elevation of cytosolic calcium ion concentration; homophilic cell adhesion; integral to membrane; long-term synaptic potentiation; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of long-term neuronal synaptic plasticity; positive regulation of neuron projection development; positive regulation of protein phosphorylation; presynaptic membrane; type 1 fibroblast growth factor receptor binding IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR027112; Neuroplastin (Stromal cell-derived receptor 1) (SDR-1) Nptn Sdfr1 Sdr1 Mus musculus (Mouse) TR41402_c1_g4_i7 Q99PA3 BASI_CRIGR 1.00E-07 GO:0016021; GO:0005537; GO:0042470; GO:0005886 integral to membrane; mannose binding; melanosome; plasma membrane IPR009151; IPR007110; IPR013783; IPR013098; IPR003599; Basigin (CD antigen CD147) (Fragment) BSG Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR41403_c0_g2_i1 Q9NXL6 SIDT1_HUMAN 2.00E-149 GO:0051033; GO:0033227; GO:0016021 RNA transmembrane transporter activity; dsRNA transport; integral to membrane IPR025958; SID1 transmembrane family member 1 SIDT1 Homo sapiens (Human) TR41403_c0_g2_i3 Q9GZC8 SID1_CAEEL 9.00E-20 GO:0016246; GO:0051033; GO:0033227; GO:0005887 RNA interference; RNA transmembrane transporter activity; dsRNA transport; integral to plasma membrane IPR025958; Systemic RNA interference defective protein 1 (Systemic RNAi enabling protein) sid-1 C04F5.1 Caenorhabditis elegans TR41404_c1_g1_i1 Q3ZCF6 APC11_BOVIN 4.00E-37 GO:0005680; GO:0051301; GO:0005737; GO:0007067; GO:0070979; GO:0004842; GO:0008270 anaphase-promoting complex; cell division; cytoplasm; mitosis; protein K11-linked ubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR024991; IPR001841; IPR013083; Protein modification; protein ubiquitination. Anaphase-promoting complex subunit 11 (APC11) (Cyclosome subunit 11) ANAPC11 Bos taurus (Bovine) TR41405_c2_g1_i2 P42680 TEC_HUMAN 0 GO:0005524; GO:0050853; GO:0038095; GO:0005856; GO:0005829; GO:0045087; GO:0007229; GO:0007243; GO:0046872; GO:0004715; GO:0005543; GO:0005886; GO:0010543 ATP binding; B cell receptor signaling pathway; Fc-epsilon receptor signaling pathway; cytoskeleton; cytosol; innate immune response; integrin-mediated signaling pathway; intracellular protein kinase cascade; metal ion binding; non-membrane spanning protein tyrosine kinase activity; phospholipid binding; plasma membrane; regulation of platelet activation IPR011009; IPR011993; IPR001849; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; IPR001562; Tyrosine-protein kinase Tec (EC 2.7.10.2) TEC PSCTK4 Homo sapiens (Human) TR41405_c2_g1_i3 P08630 BTKL_DROME 2.00E-75 GO:0005524; GO:0042023; GO:0007254; GO:0030036; GO:0007349; GO:0007619; GO:0005737; GO:0008340; GO:0007391; GO:0007301; GO:0045172; GO:0008258; GO:0007485; GO:0007476; GO:0030717; GO:0046872; GO:0004715; GO:0007424; GO:0030723; GO:0005543; GO:0005886; GO:0004713; GO:0030833; GO:0007435; GO:0046960 ATP binding; DNA endoreduplication; JNK cascade; actin cytoskeleton organization; cellularization; courtship behavior; cytoplasm; determination of adult lifespan; dorsal closure; female germline ring canal formation; germline ring canal; head involution; imaginal disc-derived male genitalia development; imaginal disc-derived wing morphogenesis; karyosome formation; metal ion binding; non-membrane spanning protein tyrosine kinase activity; open tracheal system development; ovarian fusome organization; phospholipid binding; plasma membrane; protein tyrosine kinase activity; regulation of actin filament polymerization; salivary gland morphogenesis; sensitization IPR011009; IPR011993; IPR001849; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; IPR001562; Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C) (Dsrc29a) Btk29A Src2 Src29A Tec29 CG8049 Drosophila melanogaster (Fruit fly) TR41406_c3_g2_i1 Q9C801 MOS2_ARATH 2.00E-14 GO:0003723; GO:0009870; GO:0042742; GO:0005634 "RNA binding; defense response signaling pathway, resistance gene-dependent; defense response to bacterium; nucleus" IPR000467; IPR005824; Protein MOS2 MOS2 At1g33520 F10C21.16 Arabidopsis thaliana (Mouse-ear cress) TR41406_c3_g2_i2 Q90X38 GPKOW_DANRE 1.00E-63 GO:0003676; GO:0005634 nucleic acid binding; nucleus IPR000467; IPR005824; IPR014722; IPR008991; G patch domain and KOW motifs-containing protein (Protein T54-like) gpkow t54l si:dz150f13.5 zgc:152714 Danio rerio (Zebrafish) (Brachydanio rerio) TR41407_c2_g1_i1 P82458 TRI18_RAT 4.00E-13 GO:0005881; GO:0016874; GO:0032874; GO:0008270 cytoplasmic microtubule; ligase activity; positive regulation of stress-activated MAPK cascade; zinc ion binding IPR001870; IPR003649; IPR003879; IPR008985; IPR017903; IPR003961; IPR013783; IPR027727; IPR006574; IPR018355; IPR003877; IPR000315; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase Midline-1 (EC 6.3.2.-) (RING finger protein Midline-1) (Tripartite motif-containing protein 18) Mid1 Fxy Trim18 Rattus norvegicus (Rat) TR41407_c2_g1_i2 E1BD59 TRI56_BOVIN 8.00E-32 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) TR41407_c2_g1_i5 Q5BIM1 TRI45_BOVIN 3.00E-23 GO:0005737; GO:0005634; GO:0008270 cytoplasm; nucleus; zinc ion binding IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) TR41407_c2_g1_i7 O75382 TRIM3_HUMAN 1.00E-16 GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0015031; GO:0008270 cytoplasm; early endosome; nervous system development; protein C-terminus binding; protein transport; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) TR41407_c2_g1_i8 E1BD59 TRI56_BOVIN 5.00E-29 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) TR41408_c3_g3_i1 Q05909 PTPRG_MOUSE 2.00E-49 GO:0042802; GO:0016021; GO:0004725 identical protein binding; integral to membrane; protein tyrosine phosphatase activity IPR001148; IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48) Ptprg Mus musculus (Mouse) TR41410_c0_g2_i2 Q6ZQ58 LARP1_MOUSE 2.00E-137 GO:0003723; GO:0005737 RNA binding; cytoplasm IPR006607; IPR006630; IPR011991; La-related protein 1 (La ribonucleoprotein domain family member 1) Larp1 Kiaa0731 Larp Mus musculus (Mouse) TR41410_c0_g3_i1 Q9P6K0 YLA3_SCHPO 2.00E-12 GO:0003723; GO:0002181; GO:0005829; GO:0005844 RNA binding; cytoplasmic translation; cytosol; polysome IPR006630; IPR011991; Uncharacterized HTH La-type RNA-binding protein C1527.03 SPAC1527.03 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41410_c0_g3_i2 Q6ZQ58 LARP1_MOUSE 6.00E-34 GO:0003723; GO:0005737 RNA binding; cytoplasm IPR006607; IPR006630; IPR011991; La-related protein 1 (La ribonucleoprotein domain family member 1) Larp1 Kiaa0731 Larp Mus musculus (Mouse) TR41411_c0_g2_i2 Q06697 CDC73_YEAST 8.00E-17 GO:0016593; GO:0001089; GO:0003682; GO:0045910; GO:2001255; GO:2001165; GO:2001209; GO:0032968; GO:0034402; GO:2001173; GO:0090262; GO:0006362; GO:0006368; GO:0035327 P38351; Q00772 Cdc73/Paf1 complex; TFIIF-class binding transcription factor activity; chromatin binding; negative regulation of DNA recombination; positive regulation of histone H3-K36 trimethylation; positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues; positive regulation of transcription elongation from RNA polymerase I promoter; positive regulation of transcription elongation from RNA polymerase II promoter; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; regulation of histone H2B conserved C-terminal lysine ubiquitination; regulation of transcription-coupled nucleotide-excision repair; transcription elongation from RNA polymerase I promoter; transcription elongation from RNA polymerase II promoter; transcriptionally active chromatin IPR007852; Cell division control protein 73 (RNA polymerase-associated protein CDC73) CDC73 YLR418C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41411_c0_g2_i3 Q5ZLM0 CDC73_CHICK 0 GO:0016593; GO:0000993; GO:0007049; GO:0071222; GO:0001711; GO:0033523; GO:0010390; GO:0006378; GO:2000134; GO:0008285; GO:0050680; GO:0048147; GO:0045638; GO:0000122; GO:0030177; GO:0031442; GO:0032968; GO:0045944; GO:0031648; GO:0019827; GO:0006351 "Cdc73/Paf1 complex; RNA polymerase II core binding; cell cycle; cellular response to lipopolysaccharide; endodermal cell fate commitment; histone H2B ubiquitination; histone monoubiquitination; mRNA polyadenylation; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of myeloid cell differentiation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of Wnt receptor signaling pathway; positive regulation of mRNA 3'-end processing; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; protein destabilization; stem cell maintenance; transcription, DNA-dependent" IPR007852; Parafibromin (Cell division cycle protein 73 homolog) CDC73 RCJMB04_5j4 Gallus gallus (Chicken) TR41411_c0_g2_i5 Q5ZLM0 CDC73_CHICK 0 GO:0016593; GO:0000993; GO:0007049; GO:0071222; GO:0001711; GO:0033523; GO:0010390; GO:0006378; GO:2000134; GO:0008285; GO:0050680; GO:0048147; GO:0045638; GO:0000122; GO:0030177; GO:0031442; GO:0032968; GO:0045944; GO:0031648; GO:0019827; GO:0006351 "Cdc73/Paf1 complex; RNA polymerase II core binding; cell cycle; cellular response to lipopolysaccharide; endodermal cell fate commitment; histone H2B ubiquitination; histone monoubiquitination; mRNA polyadenylation; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of myeloid cell differentiation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of Wnt receptor signaling pathway; positive regulation of mRNA 3'-end processing; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; protein destabilization; stem cell maintenance; transcription, DNA-dependent" IPR007852; Parafibromin (Cell division cycle protein 73 homolog) CDC73 RCJMB04_5j4 Gallus gallus (Chicken) TR41412_c2_g1_i1 Q6NRG6 SAS6_XENLA 7.00E-11 GO:0007049; GO:0005737; GO:0005815 cell cycle; cytoplasm; microtubule organizing center Spindle assembly abnormal protein 6 homolog sas6 Xenopus laevis (African clawed frog) TR41413_c2_g1_i3 Q9Z254 GIPC1_RAT 4.00E-108 GO:0005903; GO:0005938; GO:0005829; GO:0043198; GO:0043197; GO:0030139; GO:0043542; GO:0014047; GO:0016020; GO:0032435; GO:0030511; GO:0006605; GO:0031647; GO:0048167; GO:0007268; GO:0008021; GO:0012506 brush border; cell cortex; cytosol; dendritic shaft; dendritic spine; endocytic vesicle; endothelial cell migration; glutamate secretion; membrane; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transforming growth factor beta receptor signaling pathway; protein targeting; regulation of protein stability; regulation of synaptic plasticity; synaptic transmission; synaptic vesicle; vesicle membrane IPR001478; IPR017379; PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (GLUT1 C-terminal-binding protein) (GLUT1CBP) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) Gipc1 Gipc Rgs19ip1 Rattus norvegicus (Rat) TR41414_c0_g2_i1 Q28024 GBG12_BOVIN 4.00E-12 GO:0007186; GO:0005834; GO:0004871 G-protein coupled receptor signaling pathway; heterotrimeric G-protein complex; signal transducer activity IPR015898; IPR001770; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Gamma-S1) GNG12 GNGT12 Bos taurus (Bovine) TR41416_c0_g2_i1 Q9UK58 CCNL1_HUMAN 2.00E-17 GO:0006396; GO:0016607; GO:0005634; GO:0000079; GO:0006355; GO:0006351 "RNA processing; nuclear speck; nucleus; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR013763; IPR015429; IPR017060; IPR015431; IPR006671; Cyclin-L1 (Cyclin-L) CCNL1 BM-001 UNQ530/PRO1073 Homo sapiens (Human) TR41416_c0_g2_i2 Q2QQS5 CCT14_ORYSJ 2.00E-29 GO:0007049; GO:0051301; GO:0005634; GO:0000079; GO:0006355 "cell cycle; cell division; nucleus; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription, DNA-dependent" IPR013763; IPR004367; IPR015429; IPR006671; Cyclin-T1-4 (CycT1;4) CYCT1-1 Os12g0485400 LOC_Os12g30020 Oryza sativa subsp. japonica (Rice) TR41416_c0_g2_i3 O60583 CCNT2_HUMAN 5.00E-96 GO:0007049; GO:0051301; GO:0019048; GO:0005654; GO:0045944; GO:0000079; GO:0006368; GO:0006367; GO:0007179; GO:0016032 cell cycle; cell division; modulation by virus of host morphology or physiology; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; regulation of cyclin-dependent protein serine/threonine kinase activity; transcription elongation from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; viral process IPR013763; IPR015429; IPR006671; Cyclin-T2 (CycT2) CCNT2 Homo sapiens (Human) TR41416_c0_g2_i4 Q2QQS5 CCT14_ORYSJ 2.00E-29 GO:0007049; GO:0051301; GO:0005634; GO:0000079; GO:0006355 "cell cycle; cell division; nucleus; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription, DNA-dependent" IPR013763; IPR004367; IPR015429; IPR006671; Cyclin-T1-4 (CycT1;4) CYCT1-1 Os12g0485400 LOC_Os12g30020 Oryza sativa subsp. japonica (Rice) TR41416_c0_g2_i7 O60583 CCNT2_HUMAN 1.00E-97 GO:0007049; GO:0051301; GO:0019048; GO:0005654; GO:0045944; GO:0000079; GO:0006368; GO:0006367; GO:0007179; GO:0016032 cell cycle; cell division; modulation by virus of host morphology or physiology; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; regulation of cyclin-dependent protein serine/threonine kinase activity; transcription elongation from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; viral process IPR013763; IPR015429; IPR006671; Cyclin-T2 (CycT2) CCNT2 Homo sapiens (Human) TR41416_c0_g2_i8 O60583 CCNT2_HUMAN 1.00E-97 GO:0007049; GO:0051301; GO:0019048; GO:0005654; GO:0045944; GO:0000079; GO:0006368; GO:0006367; GO:0007179; GO:0016032 cell cycle; cell division; modulation by virus of host morphology or physiology; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; regulation of cyclin-dependent protein serine/threonine kinase activity; transcription elongation from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; viral process IPR013763; IPR015429; IPR006671; Cyclin-T2 (CycT2) CCNT2 Homo sapiens (Human) TR41417_c0_g1_i3 Q96D71 REPS1_HUMAN 7.00E-38 GO:0005509; GO:0005905; GO:0005886; GO:0006898 calcium ion binding; coated pit; plasma membrane; receptor-mediated endocytosis IPR011992; IPR018247; IPR002048; IPR000261; IPR026814; RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) REPS1 Homo sapiens (Human) TR41417_c0_g1_i6 Q96D71 REPS1_HUMAN 1.00E-35 GO:0005509; GO:0005905; GO:0005886; GO:0006898 calcium ion binding; coated pit; plasma membrane; receptor-mediated endocytosis IPR011992; IPR018247; IPR002048; IPR000261; IPR026814; RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) REPS1 Homo sapiens (Human) TR41417_c0_g1_i7 Q80XA6 REPS2_MOUSE 7.00E-25 GO:0005509; GO:0005737; GO:0006898 calcium ion binding; cytoplasm; receptor-mediated endocytosis IPR011992; IPR018247; IPR002048; IPR000261; IPR026814; RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) Reps2 Pob1 Mus musculus (Mouse) TR41417_c0_g1_i8 A6ZVS5 PAN1_YEAS7 5.00E-09 GO:0030479; GO:0005509; GO:0006897; GO:0010008; GO:0005886 actin cortical patch; calcium ion binding; endocytosis; endosome membrane; plasma membrane IPR013182; IPR011992; IPR018247; IPR002048; IPR000261; IPR026812; Actin cytoskeleton-regulatory complex protein PAN1 (Mitochondrial distribution of proteins protein 3) PAN1 DIM2 MDP3 MIP3 SCY_2791 Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) TR41418_c0_g1_i1 P25169 AT1B1_ARTSF 1.00E-56 GO:0006813; GO:0006814; GO:0005890 potassium ion transport; sodium ion transport; sodium:potassium-exchanging ATPase complex IPR000402; Sodium/potassium-transporting ATPase subunit beta (Sodium/potassium-dependent ATPase beta subunit) Artemia franciscana (Brine shrimp) (Artemia sanfranciscana) TR41418_c0_g1_i3 P25169 AT1B1_ARTSF 2.00E-59 GO:0006813; GO:0006814; GO:0005890 potassium ion transport; sodium ion transport; sodium:potassium-exchanging ATPase complex IPR000402; Sodium/potassium-transporting ATPase subunit beta (Sodium/potassium-dependent ATPase beta subunit) Artemia franciscana (Brine shrimp) (Artemia sanfranciscana) TR41419_c1_g1_i1 Q8BFY9 TNPO1_MOUSE 0 GO:0005737; GO:0006886; GO:0005634 cytoplasm; intracellular protein transport; nucleus IPR011989; IPR016024; IPR001494; Transportin-1 (Importin beta-2) (Karyopherin beta-2) Tnpo1 Kpnb2 Mus musculus (Mouse) TR41419_c1_g1_i2 Q55CQ7 TNPO_DICDI 2.00E-161 GO:0005829; GO:0005635; GO:0008139; GO:0006606 cytosol; nuclear envelope; nuclear localization sequence binding; protein import into nucleus IPR011989; IPR016024; IPR001494; Transportin (Importin subunit beta) (Karyopherin subunit beta) tnpo DDB_G0269948 Dictyostelium discoideum (Slime mold) TR41419_c1_g1_i3 Q92973 TNPO1_HUMAN 0 GO:0005829; GO:0010467; GO:0016071; GO:0019048; GO:0008139; GO:0005634; GO:0000060 P62993; P62826 "cytosol; gene expression; mRNA metabolic process; modulation by virus of host morphology or physiology; nuclear localization sequence binding; nucleus; protein import into nucleus, translocation" IPR011989; IPR016024; IPR001494; Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP) TNPO1 KPNB2 MIP1 TRN Homo sapiens (Human) TR41419_c1_g1_i6 Q8BFY9 TNPO1_MOUSE 0 GO:0005737; GO:0006886; GO:0005634 cytoplasm; intracellular protein transport; nucleus IPR011989; IPR016024; IPR001494; Transportin-1 (Importin beta-2) (Karyopherin beta-2) Tnpo1 Kpnb2 Mus musculus (Mouse) TR41419_c1_g1_i7 Q92973 TNPO1_HUMAN 0 GO:0005829; GO:0010467; GO:0016071; GO:0019048; GO:0008139; GO:0005634; GO:0000060 P62993; P62826 "cytosol; gene expression; mRNA metabolic process; modulation by virus of host morphology or physiology; nuclear localization sequence binding; nucleus; protein import into nucleus, translocation" IPR011989; IPR016024; IPR001494; Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP) TNPO1 KPNB2 MIP1 TRN Homo sapiens (Human) TR41420_c1_g1_i1 P09889 PPA5_PIG 4.00E-65 GO:0003993; GO:0005576; GO:0008199; GO:0008198; GO:0006811; GO:0055072 acid phosphatase activity; extracellular region; ferric iron binding; ferrous iron binding; ion transport; iron ion homeostasis IPR024927; IPR004843; Tartrate-resistant acid phosphatase type 5 (TR-AP) (EC 3.1.3.2) (Tartrate-resistant acid ATPase) (TrATPase) (Type 5 acid phosphatase) (Uteroferrin) (UF) ACP5 Sus scrofa (Pig) TR41420_c1_g2_i3 P09889 PPA5_PIG 7.00E-37 GO:0003993; GO:0005576; GO:0008199; GO:0008198; GO:0006811; GO:0055072 acid phosphatase activity; extracellular region; ferric iron binding; ferrous iron binding; ion transport; iron ion homeostasis IPR024927; IPR004843; Tartrate-resistant acid phosphatase type 5 (TR-AP) (EC 3.1.3.2) (Tartrate-resistant acid ATPase) (TrATPase) (Type 5 acid phosphatase) (Uteroferrin) (UF) ACP5 Sus scrofa (Pig) TR41420_c1_g2_i6 Q9SCX8 PPA17_ARATH 5.00E-08 GO:0003993; GO:0009986; GO:0030643; GO:0005576; GO:0046872; GO:0004601; GO:0042542 acid phosphatase activity; cell surface; cellular phosphate ion homeostasis; extracellular region; metal ion binding; peroxidase activity; response to hydrogen peroxide IPR024927; IPR004843; Purple acid phosphatase 17 (EC 3.1.3.2) (Acid phosphatase type 5) (Peroxidase) (EC 1.11.1.7) PAP17 ACP5 At3g17790 MEB5.10 Arabidopsis thaliana (Mouse-ear cress) TR41420_c1_g2_i7 Q8S341 PPA7_ARATH 1.00E-08 GO:0003993; GO:0005576; GO:0046872 acid phosphatase activity; extracellular region; metal ion binding IPR024927; IPR004843; Purple acid phosphatase 7 (EC 3.1.3.2) PAP7 At2g01880 T23K3.7 Arabidopsis thaliana (Mouse-ear cress) TR41423_c0_g2_i1 Q6P5G6 UBXN7_MOUSE 3.00E-08 IPR012336; IPR006577; IPR009060; IPR001012; IPR017346; UBX domain-containing protein 7 Ubxn7 Kiaa0794 Ubxd7 Mus musculus (Mouse) TR41423_c0_g2_i2 P54731 FAF1_MOUSE 5.00E-161 GO:0034098; GO:0006915; GO:0008219; GO:0007253; GO:0005829; GO:0031072; GO:0005635; GO:0048471; GO:1902043; GO:0031334; GO:0019901; GO:0030155; GO:0042176 Cdc48p-Npl4p-Ufd1p AAA ATPase complex; apoptotic process; cell death; cytoplasmic sequestering of NF-kappaB; cytosol; heat shock protein binding; nuclear envelope; perinuclear region of cytoplasm; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of protein complex assembly; protein kinase binding; regulation of cell adhesion; regulation of protein catabolic process IPR012336; IPR006577; IPR001012; FAS-associated factor 1 Faf1 Mus musculus (Mouse) TR41423_c0_g2_i3 Q9UNN5 FAF1_HUMAN 8.00E-94 GO:0031265; GO:0034098; GO:0006915; GO:0008219; GO:0007253; GO:0005829; GO:0031072; GO:0005635; GO:0005634; GO:0048471; GO:0043065; GO:0031334; GO:0043161; GO:0019901; GO:0019887; GO:0030155; GO:0042176; GO:0043130; GO:0031625 CD95 death-inducing signaling complex; Cdc48p-Npl4p-Ufd1p AAA ATPase complex; apoptotic process; cell death; cytoplasmic sequestering of NF-kappaB; cytosol; heat shock protein binding; nuclear envelope; nucleus; perinuclear region of cytoplasm; positive regulation of apoptotic process; positive regulation of protein complex assembly; proteasomal ubiquitin-dependent protein catabolic process; protein kinase binding; protein kinase regulator activity; regulation of cell adhesion; regulation of protein catabolic process; ubiquitin binding; ubiquitin protein ligase binding IPR012336; IPR006577; IPR001012; FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A) FAF1 UBXD12 UBXN3A CGI-03 Homo sapiens (Human) TR41425_c0_g1_i1 Q14117 DPYS_HUMAN 0 GO:0016597; GO:0019482; GO:0005829; GO:0004157; GO:0051289; GO:0046135; GO:0002059; GO:0006210; GO:0002058; GO:0006212; GO:0008270 amino acid binding; beta-alanine metabolic process; cytosol; dihydropyrimidinase activity; protein homotetramerization; pyrimidine nucleoside catabolic process; thymine binding; thymine catabolic process; uracil binding; uracil catabolic process; zinc ion binding IPR006680; IPR011778; IPR011059; Dihydropyrimidinase (DHP) (DHPase) (EC 3.5.2.2) (Dihydropyrimidine amidohydrolase) (Hydantoinase) DPYS Homo sapiens (Human) TR41425_c0_g1_i2 A3DE07 PYRC_CLOTH 3.00E-09 GO:0044205; GO:0004151; GO:0008270 'de novo' UMP biosynthetic process; dihydroorotase activity; zinc ion binding IPR004722; IPR002195; IPR011059; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. Dihydroorotase (DHOase) (EC 3.5.2.3) pyrC Cthe_0952 Clostridium thermocellum (strain ATCC 27405 / DSM 1237) TR41425_c0_g1_i3 B3E3I1 PYRC_GEOLS 2.00E-17 GO:0044205; GO:0004151; GO:0008270 'de novo' UMP biosynthetic process; dihydroorotase activity; zinc ion binding IPR004722; IPR002195; IPR011059; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. Dihydroorotase (DHOase) (EC 3.5.2.3) pyrC Glov_2084 Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ) TR41425_c0_g1_i5 P97427 DPYL1_MOUSE 0 GO:0005737; GO:0030425; GO:0016812; GO:0005815; GO:0043025; GO:0006208; GO:0005819 "cytoplasm; dendrite; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; microtubule organizing center; neuronal cell body; pyrimidine nucleobase catabolic process; spindle" IPR006680; IPR011778; IPR011059; Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Unc-33-like phosphoprotein 3) (ULIP-3) Crmp1 Dpysl1 Ulip3 Mus musculus (Mouse) TR41425_c0_g1_i6 Q14117 DPYS_HUMAN 0 GO:0016597; GO:0019482; GO:0005829; GO:0004157; GO:0051289; GO:0046135; GO:0002059; GO:0006210; GO:0002058; GO:0006212; GO:0008270 amino acid binding; beta-alanine metabolic process; cytosol; dihydropyrimidinase activity; protein homotetramerization; pyrimidine nucleoside catabolic process; thymine binding; thymine catabolic process; uracil binding; uracil catabolic process; zinc ion binding IPR006680; IPR011778; IPR011059; Dihydropyrimidinase (DHP) (DHPase) (EC 3.5.2.2) (Dihydropyrimidine amidohydrolase) (Hydantoinase) DPYS Homo sapiens (Human) TR41425_c0_g1_i7 P71809 PYRC_MYCTU 1.00E-09 GO:0044205; GO:0004151; GO:0040007; GO:0008270 'de novo' UMP biosynthetic process; dihydroorotase activity; growth; zinc ion binding IPR004722; IPR002195; IPR011059; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. Dihydroorotase (DHOase) (EC 3.5.2.3) pyrC Rv1381 MT1425 MTCY02B12.15 Mycobacterium tuberculosis TR41425_c0_g1_i8 Q71YS6 ADEC_LISMF 5.00E-08 GO:0006146; GO:0000034 adenine catabolic process; adenine deaminase activity IPR006679; IPR026912; IPR006680; IPR011059; Adenine deaminase (Adenase) (Adenine aminase) (EC 3.5.4.2) ade LMOf2365_1767 Listeria monocytogenes serotype 4b (strain F2365) TR41427_c1_g1_i1 O88444 ADCY1_MOUSE 0 GO:0005524; GO:0007190; GO:0004016; GO:0007409; GO:0016021; GO:0035556; GO:0007616; GO:0046872; GO:0005886 ATP binding; activation of adenylate cyclase activity; adenylate cyclase activity; axonogenesis; integral to membrane; intracellular signal transduction; long-term memory; metal ion binding; plasma membrane IPR001054; IPR018297; Adenylate cyclase type 1 (EC 4.6.1.1) (ATP pyrophosphate-lyase 1) (Adenylate cyclase type I) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) Adcy1 Mus musculus (Mouse) TR41427_c1_g1_i2 P19754 ADCY1_BOVIN 2.00E-102 GO:0005524; GO:0004016; GO:0016021; GO:0035556; GO:0046872 ATP binding; adenylate cyclase activity; integral to membrane; intracellular signal transduction; metal ion binding IPR001054; IPR018297; Adenylate cyclase type 1 (EC 4.6.1.1) (ATP pyrophosphate-lyase 1) (Adenylate cyclase type I) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) ADCY1 Bos taurus (Bovine) TR41428_c1_g1_i4 Q9NRG9 AAAS_HUMAN 3.00E-163 GO:0005975; GO:0005813; GO:0019221; GO:0005737; GO:0009566; GO:0015758; GO:0007612; GO:0007077; GO:0031965; GO:0005643; GO:0006913; GO:0010827; GO:0046822; GO:0044281; GO:0055085; GO:0016032 carbohydrate metabolic process; centrosome; cytokine-mediated signaling pathway; cytoplasm; fertilization; glucose transport; learning; mitotic nuclear envelope disassembly; nuclear membrane; nuclear pore; nucleocytoplasmic transport; regulation of glucose transport; regulation of nucleocytoplasmic transport; small molecule metabolic process; transmembrane transport; viral process IPR015943; IPR001680; IPR019775; IPR017986; Aladin (Adracalin) AAAS ADRACALA GL003 Homo sapiens (Human) TR41429_c3_g1_i2 Q9ER41 TOR1B_MOUSE 5.00E-46 GO:0005524; GO:0051085; GO:0005788; GO:0005635; GO:0071763; GO:0017111; GO:0051260 ATP binding; chaperone mediated protein folding requiring cofactor; endoplasmic reticulum lumen; nuclear envelope; nuclear membrane organization; nucleoside-triphosphatase activity; protein homooligomerization IPR003593; IPR027417; IPR010448; IPR017378; Torsin-1B (Torsin family 1 member B) Tor1b Mus musculus (Mouse) TR41430_c0_g3_i1 Q6BUQ2 MYO1_DEBHA 9.00E-28 GO:0005524; GO:0030479; GO:0003774; GO:0016459 ATP binding; actin cortical patch; motor activity; myosin complex IPR001609; IPR010926; IPR027417; IPR001452; Myosin-1 (Class I unconventional myosin) (Type I myosin) MYO1 DEHA2C08976g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR41430_c2_g1_i1 Q9U1M8 MYOI_DICDI 4.00E-101 GO:0005524; GO:0003779; GO:0030048; GO:0030898; GO:0031252; GO:0000902; GO:0031589; GO:0005829; GO:0030175; GO:0046847; GO:0003774; GO:0016459; GO:0001891; GO:0006909; GO:0043621; GO:0009847 ATP binding; actin binding; actin filament-based movement; actin-dependent ATPase activity; cell leading edge; cell morphogenesis; cell-substrate adhesion; cytosol; filopodium; filopodium assembly; motor activity; myosin complex; phagocytic cup; phagocytosis; protein self-association; spore germination IPR019749; IPR019748; IPR000299; IPR018980; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; IPR011511; IPR001452; Myosin-I heavy chain (Class VII unconventional myosin) (DdMVII) (DdM7) myoI DDB_G0274455 Dictyostelium discoideum (Slime mold) TR41430_c2_g1_i2 Q9Y4I1 MYO5A_HUMAN 1.00E-83 GO:0005524; GO:0005794; GO:0030048; GO:0042641; GO:0042640; GO:0005509; GO:0044267; GO:0032869; GO:0051643; GO:0006887; GO:0030426; GO:0030073; GO:0032593; GO:0005882; GO:0031987; GO:0042759; GO:0042438; GO:0030318; GO:0042470; GO:0032402; GO:0000146; GO:0035371; GO:0042552; GO:0016459; GO:0043025; GO:0042476; GO:0001750; GO:0072659; GO:0031585; GO:0001726; GO:0032252; GO:0050808; GO:0007268; GO:0016192; GO:0007601 "ATP binding; Golgi apparatus; actin filament-based movement; actomyosin; anagen; calcium ion binding; cellular protein metabolic process; cellular response to insulin stimulus; endoplasmic reticulum localization; exocytosis; growth cone; insulin secretion; insulin-responsive compartment; intermediate filament; locomotion involved in locomotory behavior; long-chain fatty acid biosynthetic process; melanin biosynthetic process; melanocyte differentiation; melanosome; melanosome transport; microfilament motor activity; microtubule plus end; myelination; myosin complex; neuronal cell body; odontogenesis; photoreceptor outer segment; protein localization to plasma membrane; regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; ruffle; secretory granule localization; synapse organization; synaptic transmission; vesicle-mediated transport; visual perception" IPR018444; IPR002710; IPR000048; IPR001609; IPR027417; "Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin)" MYO5A MYH12 Homo sapiens (Human) TR41430_c2_g1_i3 Q9U1M8 MYOI_DICDI 4.00E-102 GO:0005524; GO:0003779; GO:0030048; GO:0030898; GO:0031252; GO:0000902; GO:0031589; GO:0005829; GO:0030175; GO:0046847; GO:0003774; GO:0016459; GO:0001891; GO:0006909; GO:0043621; GO:0009847 ATP binding; actin binding; actin filament-based movement; actin-dependent ATPase activity; cell leading edge; cell morphogenesis; cell-substrate adhesion; cytosol; filopodium; filopodium assembly; motor activity; myosin complex; phagocytic cup; phagocytosis; protein self-association; spore germination IPR019749; IPR019748; IPR000299; IPR018980; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; IPR011511; IPR001452; Myosin-I heavy chain (Class VII unconventional myosin) (DdMVII) (DdM7) myoI DDB_G0274455 Dictyostelium discoideum (Slime mold) TR41430_c4_g1_i1 Q9ULM0 PKHH1_HUMAN 5.00E-34 GO:0005856; GO:0005543 cytoskeleton; phospholipid binding IPR019749; IPR014352; IPR019748; IPR000299; IPR000857; IPR011993; IPR001849; Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) PLEKHH1 KIAA1200 Homo sapiens (Human) TR41430_c4_g1_i2 Q9ULM0 PKHH1_HUMAN 5.00E-34 GO:0005856; GO:0005543 cytoskeleton; phospholipid binding IPR019749; IPR014352; IPR019748; IPR000299; IPR000857; IPR011993; IPR001849; Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) PLEKHH1 KIAA1200 Homo sapiens (Human) TR41430_c4_g1_i4 Q9W5D0 Y34F_DROME 7.00E-24 GO:0005856; GO:0005543 cytoskeleton; phospholipid binding IPR019749; IPR014352; IPR019748; IPR000299; IPR000857; IPR011993; IPR001849; Uncharacterized protein CG42248 CG42248 Drosophila melanogaster (Fruit fly) TR41430_c5_g1_i1 Q9UKN7 MYO15_HUMAN 3.00E-18 GO:0005524; GO:0005737; GO:0042472; GO:0007626; GO:0003774; GO:0016459; GO:0007605; GO:0032420 ATP binding; cytoplasm; inner ear morphogenesis; locomotory behavior; motor activity; myosin complex; sensory perception of sound; stereocilium IPR019749; IPR019748; IPR000299; IPR000048; IPR001609; IPR000857; IPR027417; IPR011511; IPR001452; Unconventional myosin-XV (Unconventional myosin-15) MYO15A MYO15 Homo sapiens (Human) TR41431_c0_g5_i1 P62870 ELOB_RAT 5.00E-53 GO:0001076; GO:0030891; GO:0005634; GO:0045944; GO:0016567; GO:0005667 RNA polymerase II transcription factor binding transcription factor activity; VCB complex; nucleus; positive regulation of transcription from RNA polymerase II promoter; protein ubiquitination; transcription factor complex IPR000626; Protein modification; protein ubiquitination. Transcription elongation factor B polypeptide 2 (Elongin 18 kDa subunit) (Elongin-B) (EloB) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) Tceb2 Rattus norvegicus (Rat) TR41432_c1_g4_i3 Q6BEA0 PLXA4_DANRE 9.00E-70 GO:0007411; GO:0007414; GO:0016021; GO:0005622; GO:0001763; GO:0005886; GO:0004872; GO:0007165 axon guidance; axonal defasciculation; integral to membrane; intracellular; morphogenesis of a branching structure; plasma membrane; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A4 plxna4 Danio rerio (Zebrafish) (Brachydanio rerio) TR41432_c1_g4_i5 Q6BEA0 PLXA4_DANRE 7.00E-66 GO:0007411; GO:0007414; GO:0016021; GO:0005622; GO:0001763; GO:0005886; GO:0004872; GO:0007165 axon guidance; axonal defasciculation; integral to membrane; intracellular; morphogenesis of a branching structure; plasma membrane; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A4 plxna4 Danio rerio (Zebrafish) (Brachydanio rerio) TR41433_c0_g1_i1 Q9UNX4 WDR3_HUMAN 0 GO:0031965; GO:0005730 nuclear membrane; nucleolus IPR020472; IPR007148; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 3 WDR3 Homo sapiens (Human) TR41433_c0_g1_i2 Q4P8R5 MDV1_USTMA 4.00E-07 GO:0005741 mitochondrial outer membrane IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Mitochondrial division protein 1 MDV1 UM03498 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR41433_c0_g2_i1 Q8VEJ4 NLE1_MOUSE 3.00E-10 GO:0007219; GO:0001826; GO:2001268; GO:0005730; GO:0090263 Notch signaling pathway; inner cell mass cell differentiation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; nucleolus; positive regulation of canonical Wnt receptor signaling pathway IPR020472; IPR001632; IPR012972; IPR015943; IPR001680; IPR019775; IPR017986; Notchless protein homolog 1 Nle1 Mus musculus (Mouse) TR41433_c0_g2_i2 P25382 NLE1_YEAST 2.00E-09 GO:0005730; GO:0000027 Q12019 nucleolus; ribosomal large subunit assembly IPR020472; IPR012972; IPR015943; IPR001680; IPR019775; IPR017986; Ribosome assembly protein 4 RSA4 YCR072C YCR72C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41433_c0_g2_i3 O74319 TAF73_SCHPO 7.00E-13 GO:0000991; GO:0005829; GO:0030071; GO:0006355; GO:0005669; GO:0006367 "core RNA polymerase II binding transcription factor activity; cytosol; regulation of mitotic metaphase/anaphase transition; regulation of transcription, DNA-dependent; transcription factor TFIID complex; transcription initiation from RNA polymerase II promoter" IPR020472; IPR006594; IPR007582; IPR015943; IPR001680; IPR019775; IPR017986; Transcription initiation factor TFIID subunit taf73 (Transcription initiation factor TFIID 73 kDa subunit) (TAFII-73) taf73 SPBC15D4.14 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41433_c0_g2_i4 P74598 Y1491_SYNY3 4.00E-11 GO:0030288 outer membrane-bounded periplasmic space IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; Uncharacterized WD repeat-containing protein sll1491 sll1491 Synechocystis sp. (strain PCC 6803 / Kazusa) TR41434_c1_g1_i1 Q9NRL3 STRN4_HUMAN 9.00E-57 GO:0005516; GO:0005737; GO:0043197; GO:0016020; GO:0032403; GO:0051721 P05412 calmodulin binding; cytoplasm; dendritic spine; membrane; protein complex binding; protein phosphatase 2A binding IPR020472; IPR013258; IPR015943; IPR001680; IPR019775; IPR017986; Striatin-4 (Zinedin) STRN4 ZIN Homo sapiens (Human) TR41434_c1_g1_i3 Q13033 STRN3_HUMAN 3.00E-178 GO:0005794; GO:0005516; GO:0005737; GO:0030425; GO:0033147; GO:0000122; GO:0045892; GO:0043025; GO:0005654; GO:0005634; GO:0005886; GO:0045944; GO:0043234; GO:0032403; GO:0051721; GO:0032355; GO:0003700 Q9P2B4; O43815; Q9Y228 "Golgi apparatus; calmodulin binding; cytoplasm; dendrite; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neuronal cell body; nucleoplasm; nucleus; plasma membrane; positive regulation of transcription from RNA polymerase II promoter; protein complex; protein complex binding; protein phosphatase 2A binding; response to estradiol stimulus; sequence-specific DNA binding transcription factor activity" IPR020472; IPR013258; IPR015943; IPR001680; IPR019775; IPR017986; Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen) STRN3 GS2NA SG2NA Homo sapiens (Human) TR41434_c1_g1_i4 Q6BU94 PRP46_DEBHA 3.00E-10 GO:0008380; GO:0007049; GO:0005737; GO:0006397; GO:0005681 RNA splicing; cell cycle; cytoplasm; mRNA processing; spliceosomal complex IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Pre-mRNA-splicing factor PRP46 (Pre-mRNA-processing protein 46) PRP46 DEHA2C12650g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR41434_c1_g1_i6 A6Q486 DNAJ_NITSB 1.00E-07 GO:0005524; GO:0006260; GO:0005737; GO:0006457; GO:0009408; GO:0008270 ATP binding; DNA replication; cytoplasm; protein folding; response to heat; zinc ion binding IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; Chaperone protein DnaJ dnaJ NIS_1186 Nitratiruptor sp. (strain SB155-2) TR41434_c1_g3_i1 A5D7H2 STRN3_BOVIN 2.00E-89 GO:0005794; GO:0005737; GO:0000122; GO:0005654; GO:0005886; GO:0045944; GO:0000159; GO:0003700 Golgi apparatus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; plasma membrane; positive regulation of transcription from RNA polymerase II promoter; protein phosphatase type 2A complex; sequence-specific DNA binding transcription factor activity IPR020472; IPR013258; IPR015943; IPR001680; IPR019775; IPR017986; Striatin-3 STRN3 Bos taurus (Bovine) TR41434_c1_g5_i1 Q4QJW5 DNAJ_HAEI8 3.00E-09 GO:0005524; GO:0006260; GO:0005737; GO:0006457; GO:0009408; GO:0008270 ATP binding; DNA replication; cytoplasm; protein folding; response to heat; zinc ion binding IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; Chaperone protein DnaJ dnaJ NTHI1928 Haemophilus influenzae (strain 86-028NP) TR41435_c3_g1_i2 P18091 ACTN_DROME 0 GO:0030018; GO:0003779; GO:0031532; GO:0005509; GO:0007016; GO:0007629; GO:0005925; GO:0045214 Z disc; actin binding; actin cytoskeleton reorganization; calcium ion binding; cytoskeletal anchoring at plasma membrane; flight behavior; focal adhesion; sarcomere organization IPR001589; IPR001715; IPR011992; IPR014837; IPR018247; IPR002048; IPR018159; IPR002017; "Alpha-actinin, sarcomeric (F-actin cross-linking protein)" Actn fliA l(1)2Cb CG4376 Drosophila melanogaster (Fruit fly) TR41435_c3_g1_i6 P11277 SPTB1_HUMAN 5.00E-120 GO:0051015; GO:0051693; GO:0007411; GO:0009986; GO:0005829; GO:0030097; GO:0031235; GO:0007009; GO:0006779; GO:0043234; GO:0008091; GO:0014731; GO:0005200 O95295 actin filament binding; actin filament capping; axon guidance; cell surface; cytosol; hemopoiesis; intrinsic to internal side of plasma membrane; plasma membrane organization; porphyrin-containing compound biosynthetic process; protein complex; spectrin; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR001589; IPR001715; IPR018159; IPR016343; IPR002017; "Spectrin beta chain, erythrocytic (Beta-I spectrin)" SPTB SPTB1 Homo sapiens (Human) TR41435_c3_g1_i7 P18091 ACTN_DROME 0 GO:0030018; GO:0003779; GO:0031532; GO:0005509; GO:0007016; GO:0007629; GO:0005925; GO:0045214 Z disc; actin binding; actin cytoskeleton reorganization; calcium ion binding; cytoskeletal anchoring at plasma membrane; flight behavior; focal adhesion; sarcomere organization IPR001589; IPR001715; IPR011992; IPR014837; IPR018247; IPR002048; IPR018159; IPR002017; "Alpha-actinin, sarcomeric (F-actin cross-linking protein)" Actn fliA l(1)2Cb CG4376 Drosophila melanogaster (Fruit fly) TR41435_c3_g1_i8 P18091 ACTN_DROME 0 GO:0030018; GO:0003779; GO:0031532; GO:0005509; GO:0007016; GO:0007629; GO:0005925; GO:0045214 Z disc; actin binding; actin cytoskeleton reorganization; calcium ion binding; cytoskeletal anchoring at plasma membrane; flight behavior; focal adhesion; sarcomere organization IPR001589; IPR001715; IPR011992; IPR014837; IPR018247; IPR002048; IPR018159; IPR002017; "Alpha-actinin, sarcomeric (F-actin cross-linking protein)" Actn fliA l(1)2Cb CG4376 Drosophila melanogaster (Fruit fly) TR41436_c0_g1_i2 P98150 NFKB2_CHICK 1.00E-89 GO:0003677; GO:0005737; GO:0005634; GO:0003700; GO:0007165; GO:0006351 "DNA binding; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; signal transduction; transcription, DNA-dependent" IPR002110; IPR020683; IPR011029; IPR000488; IPR013783; IPR014756; IPR002909; IPR000451; IPR008967; IPR011539; Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (Lyt-10) (Nuclear factor NF-kappa-B p97 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit (Nuclear factor NF-kappa-B p50B subunit)] NFKB2 Gallus gallus (Chicken) TR41436_c0_g2_i1 Q63369 NFKB1_RAT 6.00E-56 GO:0005829; GO:0003690; GO:0043066; GO:0001818; GO:0050728; GO:0045083; GO:0045892; GO:0005634; GO:0045944; GO:0043234; GO:0009617; GO:0046688; GO:0006979; GO:0003700; GO:0007165; GO:0000976; GO:0006351 P47196; Q99N34 "cytosol; double-stranded DNA binding; negative regulation of apoptotic process; negative regulation of cytokine production; negative regulation of inflammatory response; negative regulation of interleukin-12 biosynthetic process; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of transcription from RNA polymerase II promoter; protein complex; response to bacterium; response to copper ion; response to oxidative stress; sequence-specific DNA binding transcription factor activity; signal transduction; transcription regulatory region sequence-specific DNA binding; transcription, DNA-dependent" IPR002110; IPR020683; IPR011029; IPR000488; Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] (Fragment) Nfkb1 Rattus norvegicus (Rat) TR41436_c0_g2_i2 Q6F3J0 NFKB1_CANFA 2.00E-54 GO:0071347; GO:0071260; GO:0005829; GO:0005739; GO:0010956; GO:0001818; GO:0050728; GO:0045083; GO:0000122; GO:0001071; GO:0005634; GO:0090263; GO:1900127; GO:0045944; GO:0045893; GO:0000975; GO:0003700; GO:0007165; GO:0000976; GO:0006351 "cellular response to interleukin-1; cellular response to mechanical stimulus; cytosol; mitochondrion; negative regulation of calcidiol 1-monooxygenase activity; negative regulation of cytokine production; negative regulation of inflammatory response; negative regulation of interleukin-12 biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; nucleic acid binding transcription factor activity; nucleus; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of hyaluronan biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; signal transduction; transcription regulatory region sequence-specific DNA binding; transcription, DNA-dependent" IPR002110; IPR020683; IPR011029; IPR000488; IPR013783; IPR014756; IPR002909; IPR000451; IPR008967; IPR011539; Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] NFKB1 Canis familiaris (Dog) (Canis lupus familiaris) TR41436_c0_g2_i3 Q04861 NFKB1_CHICK 7.00E-55 GO:0002755; GO:0051059; GO:0035419; GO:0007250; GO:0005829; GO:0045087; GO:0001818; GO:0050728; GO:0045083; GO:0045892; GO:0005634; GO:0045944; GO:0043565; GO:0003700; GO:0035681; GO:0034134; GO:0035682; GO:0034138; GO:0034142; GO:0034146; GO:0034154; GO:0006351 "MyD88-dependent toll-like receptor signaling pathway; NF-kappaB binding; activation of MAPK activity involved in innate immune response; activation of NF-kappaB-inducing kinase activity; cytosol; innate immune response; negative regulation of cytokine production; negative regulation of inflammatory response; negative regulation of interleukin-12 biosynthetic process; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; toll-like receptor 15 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 21 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 7 signaling pathway; transcription, DNA-dependent" IPR002110; IPR020683; IPR011029; IPR000488; IPR013783; IPR014756; IPR002909; IPR000451; IPR008967; IPR011539; Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] NFKB1 Gallus gallus (Chicken) TR41436_c0_g2_i4 P19838 NFKB1_HUMAN 7.00E-54 GO:0038095; GO:0033256; GO:0002755; GO:0050852; GO:0035666; GO:0006915; GO:0071347; GO:0071260; GO:0005829; GO:0003690; GO:0006954; GO:0045087; GO:0031293; GO:0005739; GO:0043066; GO:0010956; GO:0032269; GO:0032375; GO:0001818; GO:0050728; GO:0045083; GO:0000122; GO:0010957; GO:0048011; GO:0005654; GO:0051092; GO:0090263; GO:1900127; GO:0010884; GO:0010744; GO:0045944; GO:0045893; GO:0032481; GO:0009617; GO:0046688; GO:0006979; GO:0003700; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124; GO:0008134; GO:0006366; GO:0000976 Q92887; P35222; P03372; Q13547; Q00653; P25963; P46531; Q14690; Q8IZL8; Q8IV08; Q04206; Q01201; P23396; Q8NFZ5 "Fc-epsilon receptor signaling pathway; I-kappaB/NF-kappaB complex; MyD88-dependent toll-like receptor signaling pathway; T cell receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; apoptotic process; cellular response to interleukin-1; cellular response to mechanical stimulus; cytosol; double-stranded DNA binding; inflammatory response; innate immune response; membrane protein intracellular domain proteolysis; mitochondrion; negative regulation of apoptotic process; negative regulation of calcidiol 1-monooxygenase activity; negative regulation of cellular protein metabolic process; negative regulation of cholesterol transport; negative regulation of cytokine production; negative regulation of inflammatory response; negative regulation of interleukin-12 biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of vitamin D biosynthetic process; neurotrophin TRK receptor signaling pathway; nucleoplasm; positive regulation of NF-kappaB transcription factor activity; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of hyaluronan biosynthetic process; positive regulation of lipid storage; positive regulation of macrophage derived foam cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of type I interferon production; response to bacterium; response to copper ion; response to oxidative stress; sequence-specific DNA binding transcription factor activity; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor TLR1:TLR2 signaling pathway; toll-like receptor TLR6:TLR2 signaling pathway; transcription factor binding; transcription from RNA polymerase II promoter; transcription regulatory region sequence-specific DNA binding" IPR002110; IPR020683; IPR011029; IPR000488; IPR013783; IPR014756; IPR002909; IPR000451; IPR008967; IPR011539; Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] NFKB1 Homo sapiens (Human) TR41438_c3_g1_i1 P29374 ARI4A_HUMAN 6.00E-52 GO:0003677; GO:0048821; GO:0080182; GO:0036124; GO:0034773; GO:0045892; GO:0006349; GO:0003700; GO:0006366; GO:0017053 "DNA binding; erythrocyte development; histone H3-K4 trimethylation; histone H3-K9 trimethylation; histone H4-K20 trimethylation; negative regulation of transcription, DNA-dependent; regulation of gene expression by genetic imprinting; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; transcriptional repressor complex" IPR001606; IPR000953; IPR016197; IPR012603; IPR002999; IPR025995; AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) ARID4A RBBP1 RBP1 Homo sapiens (Human) TR41438_c4_g1_i2 A6PWV5 ARI3C_MOUSE 2.00E-12 GO:0003677; GO:0003682; GO:0005737; GO:0045121; GO:0005634; GO:0045944; GO:0006351 "DNA binding; chromatin binding; cytoplasm; membrane raft; nucleus; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR001606; IPR023334; AT-rich interactive domain-containing protein 3C (ARID domain-containing protein 3C) Arid3c Mus musculus (Mouse) TR41438_c4_g1_i3 Q9Y0I1 EAF3_DROME 8.00E-06 GO:0006281; GO:0035267; GO:0006342; GO:0016573; GO:0043486; GO:0035064; GO:0006351 "DNA repair; NuA4 histone acetyltransferase complex; chromatin silencing; histone acetylation; histone exchange; methylated histone residue binding; transcription, DNA-dependent" IPR000953; IPR016197; IPR008676; IPR026541; IPR025995; NuA4 complex subunit EAF3 homolog (Protein MRG15) MRG15 CG6363 Drosophila melanogaster (Fruit fly) TR41439_c0_g2_i1 Q86SQ0 PHLB2_HUMAN 3.00E-86 GO:0005737; GO:0045111; GO:0005543; GO:0005886 P21333 cytoplasm; intermediate filament cytoskeleton; phospholipid binding; plasma membrane IPR011993; IPR001849; Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) PHLDB2 LL5B Homo sapiens (Human) TR41439_c0_g2_i7 Q86SQ0 PHLB2_HUMAN 4.00E-86 GO:0005737; GO:0045111; GO:0005543; GO:0005886 P21333 cytoplasm; intermediate filament cytoskeleton; phospholipid binding; plasma membrane IPR011993; IPR001849; Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) PHLDB2 LL5B Homo sapiens (Human) TR4144_c0_g1_i1 Q9BXW9 FACD2_HUMAN 7.00E-10 GO:0006281; GO:0000793; GO:0007276; GO:0005654; GO:0010332; GO:0007129 P51587; Q9NVI1; Q16658; O00255; P49959; O60934 DNA repair; condensed chromosome; gamete generation; nucleoplasm; response to gamma radiation; synapsis Fanconi anemia group D2 protein (Protein FACD2) FANCD2 FACD Homo sapiens (Human) TR41440_c4_g2_i1 Q02861 CRTI_MYXXA 1.00E-07 GO:0016117; GO:0016627 "carotenoid biosynthetic process; oxidoreductase activity, acting on the CH-CH group of donors" IPR014105; IPR006076; IPR008150; Carotenoid biosynthesis; lycopene biosynthesis. All-trans-zeta-carotene desaturase (EC 1.3.99.26) (Phytoene dehydrogenase) (Phytoene desaturase) carC crtIb Myxococcus xanthus TR41440_c4_g2_i2 P17054 CRTI_RHOCB 1.00E-06 GO:0071949; GO:0016120; GO:0016117; GO:0016627 "FAD binding; carotene biosynthetic process; carotenoid biosynthetic process; oxidoreductase activity, acting on the CH-CH group of donors" IPR002937; IPR014105; IPR008150; Carotenoid biosynthesis. Phytoene desaturase (neurosporene-forming) (EC 1.3.99.28) (3-step phytoene desaturase) (Phytoene dehydrogenase) crtI RCAP_rcc00679 Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) TR41440_c4_g2_i3 Q8N2H3 PYRD2_HUMAN 4.00E-104 GO:0016491 oxidoreductase activity Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (EC 1.-.-.-) PYROXD2 C10orf33 Homo sapiens (Human) TR41440_c4_g2_i4 Q4L978 CRTP_STAHJ 7.00E-06 GO:0016117; GO:0016491 carotenoid biosynthetic process; oxidoreductase activity IPR002937; IPR014105; Carotenoid biosynthesis; staphyloxanthin biosynthesis; staphyloxanthin from farnesyl diphosphate: step 3/5. "Diapolycopene oxygenase (EC 1.14.99.44) (4,4'-diaponeurosporene oxidase)" crtP SH0488 Staphylococcus haemolyticus (strain JCSC1435) TR41442_c1_g1_i1 Q155Q3 DIXC1_HUMAN 6.00E-08 GO:0016055; GO:0043679; GO:0043010; GO:0005938; GO:0021695; GO:0005829; GO:0005925; GO:0030900; GO:0043015; GO:0031435; GO:0043025; GO:0050772; GO:0090263; GO:0046328; GO:0004871 O14641; Q60838 Wnt receptor signaling pathway; axon terminus; camera-type eye development; cell cortex; cerebellar cortex development; cytosol; focal adhesion; forebrain development; gamma-tubulin binding; mitogen-activated protein kinase kinase kinase binding; neuronal cell body; positive regulation of axonogenesis; positive regulation of canonical Wnt receptor signaling pathway; regulation of JNK cascade; signal transducer activity IPR001715; IPR001158; IPR015506; Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) DIXDC1 CCD1 KIAA1735 Homo sapiens (Human) TR41442_c1_g1_i2 Q5TZ18 NAV3_DANRE 3.00E-07 GO:0005524; GO:0005640; GO:0017111 ATP binding; nuclear outer membrane; nucleoside-triphosphatase activity IPR003593; IPR003959; IPR001715; IPR027417; Neuron navigator 3 nav3 si:dkeyp-60g2.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR41442_c1_g1_i3 P46939 UTRO_HUMAN 4.00E-07 GO:0003779; GO:0005509; GO:0030054; GO:0005737; GO:0005856; GO:0016010; GO:0030175; GO:0006936; GO:0007517; GO:0031594; GO:0005634; GO:0005886; GO:0001954; GO:0045211; GO:0043234; GO:2000649; GO:0008270 actin binding; calcium ion binding; cell junction; cytoplasm; cytoskeleton; dystrophin-associated glycoprotein complex; filopodium; muscle contraction; muscle organ development; neuromuscular junction; nucleus; plasma membrane; positive regulation of cell-matrix adhesion; postsynaptic membrane; protein complex; regulation of sodium ion transmembrane transporter activity; zinc ion binding IPR001589; IPR001715; IPR016344; IPR011992; IPR015153; IPR015154; IPR018159; IPR002017; IPR001202; IPR000433; Utrophin (Dystrophin-related protein 1) (DRP-1) UTRN DMDL DRP1 Homo sapiens (Human) TR41442_c1_g1_i5 Q5GN48 DMD_PIG 5.00E-06 GO:0005509; GO:0030054; GO:0005737; GO:0005856; GO:0045211; GO:0042383; GO:0008270 calcium ion binding; cell junction; cytoplasm; cytoskeleton; postsynaptic membrane; sarcolemma; zinc ion binding IPR001589; IPR001715; IPR016344; IPR011992; IPR015153; IPR015154; IPR018159; IPR002017; IPR001202; IPR000433; Dystrophin DMD Sus scrofa (Pig) TR41443_c1_g1_i1 Q80X50 UBP2L_MOUSE 5.00E-13 GO:0005671; GO:0007339 Ada2/Gcn5/Ada3 transcription activator complex; binding of sperm to zona pellucida IPR022166; IPR009060; IPR015940; Ubiquitin-associated protein 2-like Ubap2l Mus musculus (Mouse) TR41443_c1_g1_i2 Q14157 UBP2L_HUMAN 5.00E-13 GO:0007339 binding of sperm to zona pellucida IPR022166; IPR009060; IPR015940; Ubiquitin-associated protein 2-like (Protein NICE-4) UBAP2L KIAA0144 NICE4 Homo sapiens (Human) TR41444_c1_g2_i1 O42101 NR5A2_CHICK 7.00E-56 GO:0005634; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR016355; IPR001723; IPR001628; IPR013088; Nuclear receptor subfamily 5 group A member 2 (FTF/LRH-1) (OR2.0) NR5A2 Gallus gallus (Chicken) TR41444_c1_g2_i2 P33242 STF1_MOUSE 4.00E-49 GO:0003677; GO:0003705; GO:0030325; GO:0030154; GO:0003682; GO:0003690; GO:0042445; GO:0001553; GO:0051457; GO:0008584; GO:0010259; GO:2000195; GO:0005634; GO:0005543; GO:2000020; GO:0045944; GO:0043565; GO:0003707; GO:0009888; GO:0008270 DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; adrenal gland development; cell differentiation; chromatin binding; double-stranded DNA binding; hormone metabolic process; luteinization; maintenance of protein location in nucleus; male gonad development; multicellular organismal aging; negative regulation of female gonad development; nucleus; phospholipid binding; positive regulation of male gonad development; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; steroid hormone receptor activity; tissue development; zinc ion binding IPR008946; IPR000536; IPR016355; IPR001723; IPR001628; IPR013088; Steroidogenic factor 1 (SF-1) (STF-1) (Adrenal 4-binding protein) (Embryonal LTR-binding protein) (ELP) (Embryonal long terminal repeat-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP) (Steroid hydroxylase positive regulator) Nr5a1 Ftzf1 Mus musculus (Mouse) TR41445_c1_g14_i2 P83425 HIP_MYTED 6.00E-11 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR41445_c1_g14_i3 Q9BXJ4 C1QT3_HUMAN 2.00E-08 GO:0035356; GO:0005581; GO:0005615; GO:0045444; GO:0042593; GO:0042347; GO:0010629; GO:0045721; GO:0050728; GO:1900165; GO:0071638; GO:0070374; GO:0070165; GO:0050715; GO:0051897; GO:0070206 cellular triglyceride homeostasis; collagen; extracellular space; fat cell differentiation; glucose homeostasis; negative regulation of NF-kappaB import into nucleus; negative regulation of gene expression; negative regulation of gluconeogenesis; negative regulation of inflammatory response; negative regulation of interleukin-6 secretion; negative regulation of monocyte chemotactic protein-1 production; positive regulation of ERK1 and ERK2 cascade; positive regulation of adiponectin secretion; positive regulation of cytokine secretion; positive regulation of protein kinase B signaling cascade; protein trimerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) TR41447_c0_g1_i1 Q58DK5 HEM2_BOVIN 2.00E-131 GO:0071353; GO:0006783; GO:0032791; GO:0004655; GO:0051260; GO:0006782; GO:0008270 cellular response to interleukin-4; heme biosynthetic process; lead ion binding; porphobilinogen synthase activity; protein homooligomerization; protoporphyrinogen IX biosynthetic process; zinc ion binding IPR013785; IPR001731; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4. Delta-aminolevulinic acid dehydratase (ALADH) (EC 4.2.1.24) (Porphobilinogen synthase) ALAD Bos taurus (Bovine) TR41447_c0_g1_i2 Q59295 HEM2_CLOJO 3.00E-51 GO:0046872; GO:0004655; GO:0006782 metal ion binding; porphobilinogen synthase activity; protoporphyrinogen IX biosynthetic process IPR013785; IPR001731; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4. Delta-aminolevulinic acid dehydratase (ALAD) (ALADH) (EC 4.2.1.24) (Porphobilinogen synthase) (Fragment) hemB Clostridium josui TR41449_c0_g1_i1 Q54EN4 PDI2_DICDI 1.00E-15 GO:0045454; GO:0005788; GO:0006662; GO:0045335; GO:0003756; GO:0015035; GO:0009617; GO:0019953 cell redox homeostasis; endoplasmic reticulum lumen; glycerol ether metabolic process; phagocytic vesicle; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; response to bacterium; sexual reproduction IPR005788; IPR005792; IPR005746; IPR012336; IPR017937; IPR013766; Protein disulfide-isomerase 2 (PDI2) (EC 5.3.4.1) pdi2 DDB_G0291434 Dictyostelium discoideum (Slime mold) TR41449_c0_g1_i2 Q7TN22 TXD16_MOUSE 5.00E-35 GO:0045454; GO:0005576 cell redox homeostasis; extracellular region IPR012336; IPR013766; Thioredoxin domain-containing protein 16 Txndc16 Kiaa1344 Mus musculus (Mouse) TR41449_c0_g1_i3 Q7TN22 TXD16_MOUSE 8.00E-35 GO:0045454; GO:0005576 cell redox homeostasis; extracellular region IPR012336; IPR013766; Thioredoxin domain-containing protein 16 Txndc16 Kiaa1344 Mus musculus (Mouse) TR41449_c0_g1_i4 Q54EN4 PDI2_DICDI 4.00E-15 GO:0045454; GO:0005788; GO:0006662; GO:0045335; GO:0003756; GO:0015035; GO:0009617; GO:0019953 cell redox homeostasis; endoplasmic reticulum lumen; glycerol ether metabolic process; phagocytic vesicle; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; response to bacterium; sexual reproduction IPR005788; IPR005792; IPR005746; IPR012336; IPR017937; IPR013766; Protein disulfide-isomerase 2 (PDI2) (EC 5.3.4.1) pdi2 DDB_G0291434 Dictyostelium discoideum (Slime mold) TR4145_c1_g1_i1 Q5XIA0 DZI1L_RAT 6.00E-12 GO:0005814; GO:0042384; GO:0036064; GO:0046872 centriole; cilium assembly; cilium basal body; metal ion binding IPR007087; IPR015880; Zinc finger protein DZIP1L (DAZ-interacting protein 1-like protein) Dzip1l Rattus norvegicus (Rat) TR41450_c2_g1_i1 Q86YT5 S13A5_HUMAN 5.00E-92 GO:0016323; GO:0015137; GO:0016021; GO:0005886; GO:0017153; GO:0015141; GO:0055085 basolateral plasma membrane; citrate transmembrane transporter activity; integral to membrane; plasma membrane; sodium:dicarboxylate symporter activity; succinate transmembrane transporter activity; transmembrane transport IPR001898; Solute carrier family 13 member 5 (Na(+)/citrate cotransporter) (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) SLC13A5 NACT Homo sapiens (Human) TR41450_c2_g1_i2 Q57486 Y608_HAEIN 3.00E-24 GO:0016021; GO:0005886; GO:0006814; GO:0055085; GO:0005215 integral to membrane; plasma membrane; sodium ion transport; transmembrane transport; transporter activity IPR001898; Uncharacterized transporter HI_0608 HI_0608 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) TR41450_c2_g1_i3 Q13183 S13A2_HUMAN 3.00E-125 GO:0005887; GO:0015361 integral to plasma membrane; low affinity sodium:dicarboxylate symporter activity IPR001898; Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter) SLC13A2 NADC1 SDCT1 Homo sapiens (Human) TR41450_c2_g1_i4 Q86YT5 S13A5_HUMAN 1.00E-139 GO:0016323; GO:0015137; GO:0016021; GO:0005886; GO:0017153; GO:0015141; GO:0055085 basolateral plasma membrane; citrate transmembrane transporter activity; integral to membrane; plasma membrane; sodium:dicarboxylate symporter activity; succinate transmembrane transporter activity; transmembrane transport IPR001898; Solute carrier family 13 member 5 (Na(+)/citrate cotransporter) (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) SLC13A5 NACT Homo sapiens (Human) TR41452_c3_g1_i2 P25867 UBCD1_DROME 6.00E-47 GO:0005524; GO:0051276; GO:0001751; GO:0008054; GO:0048132; GO:0030718; GO:0007140; GO:0005875; GO:0007067; GO:0016322; GO:0045676; GO:0031647; GO:0007286; GO:0004842 ATP binding; chromosome organization; compound eye photoreceptor cell differentiation; cyclin catabolic process; female germ-line stem cell division; germ-line stem cell maintenance; male meiosis; microtubule associated complex; mitosis; neuron remodeling; regulation of R7 cell differentiation; regulation of protein stability; spermatid development; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2-17 kDa (EC 6.3.2.19) (Protein effete) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) eff UbcD1 CG7425 Drosophila melanogaster (Fruit fly) TR41455_c0_g4_i8 Q7ZVF3 DHSA_DANRE 2.00E-54 GO:0050660; GO:0005743; GO:0022904; GO:0008177; GO:0006105; GO:0006099 flavin adenine dinucleotide binding; mitochondrial inner membrane; respiratory electron transport chain; succinate dehydrogenase (ubiquinone) activity; succinate metabolic process; tricarboxylic acid cycle IPR003953; IPR003952; IPR015939; IPR027477; IPR011281; IPR014006; Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp)" sdha si:dkeyp-84f11.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR41455_c0_g6_i1 Q801S2 DHSAB_XENLA 0 GO:0050660; GO:0005743; GO:0022904; GO:0008177; GO:0006105; GO:0006099 flavin adenine dinucleotide binding; mitochondrial inner membrane; respiratory electron transport chain; succinate dehydrogenase (ubiquinone) activity; succinate metabolic process; tricarboxylic acid cycle IPR003953; IPR003952; IPR015939; IPR027477; IPR011281; IPR014006; Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. "Succinate dehydrogenase [ubiquinone] flavoprotein subunit B, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II B) (Fp)" sdha-b Xenopus laevis (African clawed frog) TR41456_c1_g1_i1 P0C8M8 CCR1_MAIZE 8.00E-18 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000959; IPR000719; IPR017441; IPR002290; IPR008271; Probable serine/threonine-protein kinase CCRP1 (EC 2.7.11.21) (Cell-cycle related Protein 1) CCRP1 Zea mays (Maize) TR41456_c1_g1_i2 Q86HN7 PLK_DICDI 4.00E-19 GO:0005524; GO:0005813; GO:0007067; GO:0004674; GO:0000922 ATP binding; centrosome; mitosis; protein serine/threonine kinase activity; spindle pole IPR011009; IPR000959; IPR000719; IPR017441; IPR002290; IPR008271; Probable serine/threonine-protein kinase PLK (EC 2.7.11.1) (Polo-like kinase) PLK DDB_G0274503 Dictyostelium discoideum (Slime mold) TR41456_c1_g1_i3 Q91618 PMYT1_XENLA 1.00E-99 GO:0005524; GO:0000139; GO:0007049; GO:0005789; GO:0046872; GO:0010923; GO:0004674 ATP binding; Golgi membrane; cell cycle; endoplasmic reticulum membrane; metal ion binding; negative regulation of phosphatase activity; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; IPR016235; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) pkmyt1 myt1 Xenopus laevis (African clawed frog) TR41456_c1_g1_i4 O18209 PMY13_CAEEL 8.00E-78 GO:0005524; GO:0000139; GO:0005737; GO:0009790; GO:0019898; GO:0051327; GO:0046872; GO:0051447; GO:0002119; GO:0001556; GO:0004674; GO:0007283 ATP binding; Golgi membrane; cytoplasm; embryo development; extrinsic to membrane; meiotic M phase; metal ion binding; negative regulation of meiotic cell cycle; nematode larval development; oocyte maturation; protein serine/threonine kinase activity; spermatogenesis IPR011009; IPR000719; IPR017441; IPR008271; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3 (EC 2.7.11.1) (Lethal protein 37) (Myt1 kinase) wee-1.3 let-37 myt-1 spe-37 Y53C12A.1 Caenorhabditis elegans TR41456_c1_g1_i5 Q91618 PMYT1_XENLA 3.00E-94 GO:0005524; GO:0000139; GO:0007049; GO:0005789; GO:0046872; GO:0010923; GO:0004674 ATP binding; Golgi membrane; cell cycle; endoplasmic reticulum membrane; metal ion binding; negative regulation of phosphatase activity; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; IPR016235; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) pkmyt1 myt1 Xenopus laevis (African clawed frog) TR41456_c1_g1_i6 Q550L8 IFKB_DICDI 6.00E-14 GO:0005524; GO:0016337; GO:0031589; GO:0004694; GO:0005622 ATP binding; cell-cell adhesion; cell-substrate adhesion; eukaryotic translation initiation factor 2alpha kinase activity; intracellular IPR004154; IPR024435; IPR011009; IPR000719; IPR017441; IPR008271; Probable serine/threonine-protein kinase ifkB (EC 2.7.11.1) (Initiation factor kinase B) ifkB DDB_G0276829 Dictyostelium discoideum (Slime mold) TR41457_c1_g1_i1 Q8BSL4 HS3S5_MOUSE 1.00E-69 GO:0000139; GO:0008467; GO:0015015; GO:0016021; GO:0050819; GO:0006477; GO:0046596 "Golgi membrane; [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity; heparan sulfate proteoglycan biosynthetic process, enzymatic modification; integral to membrane; negative regulation of coagulation; protein sulfation; regulation of viral entry into host cell" IPR027417; IPR000863; Heparan sulfate glucosamine 3-O-sulfotransferase 5 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5) (Heparan sulfate 3-O-sulfotransferase 5) Hs3st5 Hs3ost5 Mus musculus (Mouse) TR41457_c1_g1_i2 Q9Y661 HS3S4_HUMAN 2.00E-52 GO:0000139; GO:0008467; GO:0005576; GO:0030201; GO:0016021 Golgi membrane; [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity; extracellular region; heparan sulfate proteoglycan metabolic process; integral to membrane IPR027417; IPR000863; Heparan sulfate glucosamine 3-O-sulfotransferase 4 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4) (3-OST-4) (Heparan sulfate 3-O-sulfotransferase 4) (h3-OST-4) HS3ST4 3OST4 Homo sapiens (Human) TR41457_c2_g1_i3 Q58D55 BGAL_BOVIN 2.00E-95 GO:0004565; GO:0005975; GO:0005764 beta-galactosidase activity; carbohydrate metabolic process; lysosome IPR026283; IPR008979; IPR019801; IPR013781; IPR001944; IPR017853; Beta-galactosidase (EC 3.2.1.23) (Acid beta-galactosidase) (Lactase) GLB1 Bos taurus (Bovine) TR41457_c2_g2_i1 Q9TRY9 BGAL_CANFA 2.00E-108 GO:0004565; GO:0005975; GO:0005764 beta-galactosidase activity; carbohydrate metabolic process; lysosome IPR026283; IPR008979; IPR019801; IPR013781; IPR001944; IPR017853; Beta-galactosidase (EC 3.2.1.23) (Acid beta-galactosidase) (Lactase) GLB1 Canis familiaris (Dog) (Canis lupus familiaris) TR41457_c2_g2_i3 Q9SCV5 BGAL7_ARATH 9.00E-39 GO:0048046; GO:0004565; GO:0030246; GO:0005975 apoplast; beta-galactosidase activity; carbohydrate binding; carbohydrate metabolic process IPR008979; IPR019801; IPR013781; IPR001944; IPR017853; IPR000922; Beta-galactosidase 7 (Lactase 7) (EC 3.2.1.23) BGAL7 At5g20710 T1M15.110 Arabidopsis thaliana (Mouse-ear cress) TR41457_c2_g2_i4 P48982 BGAL_XANMN 1.00E-55 GO:0004565; GO:0005975 beta-galactosidase activity; carbohydrate metabolic process IPR026283; IPR008979; IPR019801; IPR013781; IPR001944; IPR017853; Beta-galactosidase (Lactase) (EC 3.2.1.23) bga Xanthomonas manihotis TR41458_c0_g2_i1 P0C218 DDX20_DANRE 1.00E-178 GO:0005524; GO:0008026; GO:0003677; GO:0008380; GO:0005737; GO:0006397; GO:0005681 ATP binding; ATP-dependent helicase activity; DNA binding; RNA splicing; cytoplasm; mRNA processing; spliceosomal complex IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Probable ATP-dependent RNA helicase DDX20 (EC 3.6.4.13) (DEAD box protein 20) ddx20 Danio rerio (Zebrafish) (Brachydanio rerio) TR41460_c0_g2_i1 Q96KG9 NTKL_HUMAN 0 GO:0005524; GO:0030126; GO:0003677; GO:0005801; GO:0005793; GO:0005815; GO:0005634; GO:0004713; GO:0006355; GO:0006890; GO:0006351 "ATP binding; COPI vesicle coat; DNA binding; cis-Golgi network; endoplasmic reticulum-Golgi intermediate compartment; microtubule organizing center; nucleus; protein tyrosine kinase activity; regulation of transcription, DNA-dependent; retrograde vesicle-mediated transport, Golgi to ER; transcription, DNA-dependent" IPR011989; IPR016024; IPR011009; IPR000719; N-terminal kinase-like protein (Coated vesicle-associated kinase of 90 kDa) (SCY1-like protein 1) (Telomerase regulation-associated protein) (Telomerase transcriptional element-interacting factor) (Teratoma-associated tyrosine kinase) SCYL1 CVAK90 GKLP NTKL TAPK TEIF TRAP HT019 Homo sapiens (Human) TR41463_c1_g1_i1 Q8K0V4 CNOT3_MOUSE 1.00E-110 GO:0030014; GO:0000932; GO:0031047; GO:0033147; GO:0005634; GO:2000036; GO:0006355; GO:0006417; GO:0006351; GO:0001829 "CCR4-NOT complex; cytoplasmic mRNA processing body; gene silencing by RNA; negative regulation of intracellular estrogen receptor signaling pathway; nucleus; regulation of stem cell maintenance; regulation of transcription, DNA-dependent; regulation of translation; transcription, DNA-dependent; trophectodermal cell differentiation" IPR012270; IPR007282; IPR007207; CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) Cnot3 Not3 Mus musculus (Mouse) TR41463_c1_g1_i2 Q52JK6 VIP2_NICBE 1.00E-06 GO:0015074; GO:0005634; GO:0006355; GO:0006351 "DNA integration; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007282; Probable NOT transcription complex subunit VIP2 (Protein VIRE2 INTERACTING PROTEIN2) (NbVIP2) (Fragment) VIP2 Nicotiana benthamiana TR41463_c1_g1_i4 Q8K0V4 CNOT3_MOUSE 3.00E-59 GO:0030014; GO:0000932; GO:0031047; GO:0033147; GO:0005634; GO:2000036; GO:0006355; GO:0006417; GO:0006351; GO:0001829 "CCR4-NOT complex; cytoplasmic mRNA processing body; gene silencing by RNA; negative regulation of intracellular estrogen receptor signaling pathway; nucleus; regulation of stem cell maintenance; regulation of transcription, DNA-dependent; regulation of translation; transcription, DNA-dependent; trophectodermal cell differentiation" IPR012270; IPR007282; IPR007207; CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) Cnot3 Not3 Mus musculus (Mouse) TR41464_c1_g1_i1 Q8IV36 HID1_HUMAN 0 GO:0005797; GO:0000138; GO:0005881; GO:0090498; GO:0006886; GO:0005886; GO:0031001 O15357 Golgi medial cisterna; Golgi trans cisterna; cytoplasmic microtubule; extrinsic to Golgi membrane; intracellular protein transport; plasma membrane; response to brefeldin A IPR026705; IPR026972; Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) HID1 C17orf28 DMC1 Homo sapiens (Human) TR41465_c8_g3_i1 Q7TN88 PK1L2_MOUSE 3.00E-79 GO:0005262; GO:0005509; GO:0030246; GO:0050982; GO:0016021; GO:0016020; GO:0007218 calcium channel activity; calcium ion binding; carbohydrate binding; detection of mechanical stimulus; integral to membrane; membrane; neuropeptide signaling pathway IPR001304; IPR016186; IPR016187; IPR000203; IPR000922; IPR008976; IPR022409; IPR002859; IPR013122; IPR003915; IPR000601; IPR001024; IPR014010; Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) Pkd1l2 Mus musculus (Mouse) TR41465_c9_g1_i1 Q7Z443 PK1L3_HUMAN 2.00E-53 GO:0030246; GO:0006812; GO:0071468; GO:0001581; GO:0016021; GO:0007218 carbohydrate binding; cation transport; cellular response to acidity; detection of chemical stimulus involved in sensory perception of sour taste; integral to membrane; neuropeptide signaling pathway IPR001304; IPR016186; IPR016187; IPR000203; IPR008976; IPR013122; IPR000434; IPR001024; Polycystic kidney disease protein 1-like 3 (PC1-like 3 protein) (Polycystin-1L3) PKD1L3 Homo sapiens (Human) TR41466_c1_g1_i1 C7G0B5 PIF_PINFU 2.00E-07 GO:0008061; GO:0006030; GO:0005578 chitin binding; chitin metabolic process; proteinaceous extracellular matrix IPR002557; IPR002035; Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] Pinctada fucata (Pearl oyster) TR41469_c2_g2_i2 P12260 F13A_BOVIN 2.00E-16 GO:0007596; GO:0005737; GO:0005576; GO:0018149; GO:0003810 blood coagulation; cytoplasm; extracellular region; peptide cross-linking; protein-glutamine gamma-glutamyltransferase activity IPR023608; IPR013783; IPR014756; IPR001102; Coagulation factor XIII A chain (Coagulation factor XIIIa) (EC 2.3.2.13) (Protein-glutamine gamma-glutamyltransferase A chain) (Transglutaminase A chain) (Fragment) F13A1 F13A Bos taurus (Bovine) TR41469_c2_g4_i2 P23606 TGM1_RAT 1.00E-94 GO:0031224; GO:0031424; GO:0046872; GO:0018149; GO:0003810 intrinsic to membrane; keratinization; metal ion binding; peptide cross-linking; protein-glutamine gamma-glutamyltransferase activity IPR023608; IPR013783; IPR014756; IPR002931; IPR008958; IPR013808; IPR001102; Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) Tgm1 Rattus norvegicus (Rat) TR41470_c0_g1_i3 B3H0C8 UBIG_ACTP7 8.00E-08 GO:0008425; GO:0008689; GO:0006744 "2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; 3-demethylubiquinone-9 3-O-methyltransferase activity; ubiquinone biosynthetic process" IPR010233; Cofactor biosynthesis; ubiquinone biosynthesis. Ubiquinone biosynthesis O-methyltransferase (2-polyprenyl-6-hydroxyphenol methylase) (EC 2.1.1.222) (3-demethylubiquinone 3-O-methyltransferase) (EC 2.1.1.64) ubiG APP7_0288 Actinobacillus pleuropneumoniae serotype 7 (strain AP76) TR41470_c0_g1_i4 P20187 YT37_STRFR 5.00E-09 GO:0008168 methyltransferase activity IPR013216; IPR005149; IPR011991; Uncharacterized 37.1 kDa protein in transposon TN4556 Streptomyces fradiae (Streptomyces roseoflavus) TR41470_c0_g1_i5 Q8VHT6 AS3MT_RAT 6.00E-126 GO:0030791; GO:0018872; GO:0005829; GO:0030792; GO:0008276; GO:0046685; GO:0009404 arsenite methyltransferase activity; arsonoacetate metabolic process; cytosol; methylarsonite methyltransferase activity; protein methyltransferase activity; response to arsenic-containing substance; toxin metabolic process IPR026669; IPR025714; Arsenite methyltransferase (EC 2.1.1.137) (Methylarsonite methyltransferase) (S-adenosyl-L-methionine:arsenic(III) methyltransferase) As3mt Cyt19 Rattus norvegicus (Rat) TR41472_c0_g1_i1 Q5RB68 IF2B2_PONAB 3.00E-55 GO:0005737; GO:0005856; GO:0003730; GO:0048027; GO:0051028; GO:0000166; GO:0005634; GO:0006417 cytoplasm; cytoskeleton; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR004087; IPR004088; IPR012677; IPR000504; Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) IGF2BP2 VICKZ2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41472_c0_g1_i10 Q5SF07 IF2B2_MOUSE 7.00E-56 GO:0005737; GO:0005856; GO:0003730; GO:0048027; GO:0051028; GO:0000166; GO:0005634; GO:0006417 cytoplasm; cytoskeleton; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR004087; IPR004088; IPR012677; IPR000504; Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) Igf2bp2 Imp2 Vickz2 Mus musculus (Mouse) TR41472_c0_g1_i11 Q5RB68 IF2B2_PONAB 3.00E-55 GO:0005737; GO:0005856; GO:0003730; GO:0048027; GO:0051028; GO:0000166; GO:0005634; GO:0006417 cytoplasm; cytoskeleton; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR004087; IPR004088; IPR012677; IPR000504; Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) IGF2BP2 VICKZ2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41472_c0_g1_i15 Q5SF07 IF2B2_MOUSE 7.00E-56 GO:0005737; GO:0005856; GO:0003730; GO:0048027; GO:0051028; GO:0000166; GO:0005634; GO:0006417 cytoplasm; cytoskeleton; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR004087; IPR004088; IPR012677; IPR000504; Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) Igf2bp2 Imp2 Vickz2 Mus musculus (Mouse) TR41472_c0_g1_i18 Q5SF07 IF2B2_MOUSE 7.00E-56 GO:0005737; GO:0005856; GO:0003730; GO:0048027; GO:0051028; GO:0000166; GO:0005634; GO:0006417 cytoplasm; cytoskeleton; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR004087; IPR004088; IPR012677; IPR000504; Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) Igf2bp2 Imp2 Vickz2 Mus musculus (Mouse) TR41472_c0_g1_i2 O57526 IF23B_XENLA 1.00E-49 GO:0003677; GO:0005783; GO:0003730; GO:0051028; GO:0007275; GO:0000166; GO:0005634; GO:0006355; GO:0006417; GO:0006351 "DNA binding; endoplasmic reticulum; mRNA 3'-UTR binding; mRNA transport; multicellular organismal development; nucleotide binding; nucleus; regulation of transcription, DNA-dependent; regulation of translation; transcription, DNA-dependent" IPR004087; IPR004088; IPR012677; IPR000504; Insulin-like growth factor 2 mRNA-binding protein 3-B (IGF2 mRNA-binding protein 3-B) (IMP-3-B) (69 kDa RNA-binding protein B) (B3.65 protein B) (IGF-II mRNA-binding protein 3-B) (KH domain-containing transcription factor B3-B) (RNA-binding protein Vera-B) (Trans-acting factor B3-B) (VICKZ family member 3-B) (VLE-binding protein B) (Vg1 RNA-binding protein B) (Vg1 RBP-B) (Vg1 localization element binding protein B) (VgLE-binding and ER association protein B) igf2bp3-b vickz3-b Xenopus laevis (African clawed frog) TR41472_c0_g1_i3 Q5SF07 IF2B2_MOUSE 7.00E-56 GO:0005737; GO:0005856; GO:0003730; GO:0048027; GO:0051028; GO:0000166; GO:0005634; GO:0006417 cytoplasm; cytoskeleton; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR004087; IPR004088; IPR012677; IPR000504; Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) Igf2bp2 Imp2 Vickz2 Mus musculus (Mouse) TR41472_c0_g1_i4 Q5RB68 IF2B2_PONAB 3.00E-55 GO:0005737; GO:0005856; GO:0003730; GO:0048027; GO:0051028; GO:0000166; GO:0005634; GO:0006417 cytoplasm; cytoskeleton; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR004087; IPR004088; IPR012677; IPR000504; Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) IGF2BP2 VICKZ2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41472_c0_g1_i5 Q5RB68 IF2B2_PONAB 3.00E-55 GO:0005737; GO:0005856; GO:0003730; GO:0048027; GO:0051028; GO:0000166; GO:0005634; GO:0006417 cytoplasm; cytoskeleton; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR004087; IPR004088; IPR012677; IPR000504; Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) IGF2BP2 VICKZ2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41472_c0_g1_i6 Q5SF07 IF2B2_MOUSE 7.00E-56 GO:0005737; GO:0005856; GO:0003730; GO:0048027; GO:0051028; GO:0000166; GO:0005634; GO:0006417 cytoplasm; cytoskeleton; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR004087; IPR004088; IPR012677; IPR000504; Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) Igf2bp2 Imp2 Vickz2 Mus musculus (Mouse) TR41473_c2_g5_i1 Q29RU2 OIT3_BOVIN 6.00E-18 GO:0005509; GO:0005635 calcium ion binding; nuclear envelope IPR000742; IPR000152; IPR018097; IPR009030; IPR001507; Oncoprotein-induced transcript 3 protein OIT3 Bos taurus (Bovine) TR41473_c2_g5_i2 Q5R5C1 UROM_PONAB 2.00E-11 GO:0031225; GO:0016324; GO:0016323; GO:0005509; GO:0048878; GO:0060170; GO:0007588; GO:0005576; GO:0072218; GO:0072221; GO:0072233; GO:0072372; GO:2000021; GO:0000922 anchored to membrane; apical plasma membrane; basolateral plasma membrane; calcium ion binding; chemical homeostasis; cilium membrane; excretion; extracellular region; metanephric ascending thin limb development; metanephric distal convoluted tubule development; metanephric thick ascending limb development; primary cilium; regulation of ion homeostasis; spindle pole IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR023413; IPR009030; IPR001507; IPR017977; "Uromodulin [Cleaved into: Uromodulin, secreted form]" UMOD Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41473_c2_g5_i5 P25291 GP2_CANFA 2.00E-15 GO:0031225; GO:0005576; GO:0005886 anchored to membrane; extracellular region; plasma membrane IPR001507; IPR017977; Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) GP2 Canis familiaris (Dog) (Canis lupus familiaris) TR41474_c0_g1_i1 Q13796 SHRM2_HUMAN 8.00E-25 GO:0051015; GO:0016324; GO:0045176; GO:0008013; GO:0007420; GO:0005938; GO:0016477; GO:0005913; GO:0045217; GO:0043482; GO:0005856; GO:0043583; GO:0032401; GO:0008057; GO:0031941; GO:0002089; GO:0015280; GO:0032438; GO:0005874; GO:0030835; GO:0043025; GO:0005923 P16333 actin filament binding; apical plasma membrane; apical protein localization; beta-catenin binding; brain development; cell cortex; cell migration; cell-cell adherens junction; cell-cell junction maintenance; cellular pigment accumulation; cytoskeleton; ear development; establishment of melanosome localization; eye pigment granule organization; filamentous actin; lens morphogenesis in camera-type eye; ligand-gated sodium channel activity; melanosome organization; microtubule; negative regulation of actin filament depolymerization; neuronal cell body; tight junction IPR014800; IPR014799; IPR001478; IPR027686; IPR027685; Protein Shroom2 (Apical-like protein) (Protein APXL) SHROOM2 APXL Homo sapiens (Human) TR41474_c0_g1_i2 Q13796 SHRM2_HUMAN 2.00E-24 GO:0051015; GO:0016324; GO:0045176; GO:0008013; GO:0007420; GO:0005938; GO:0016477; GO:0005913; GO:0045217; GO:0043482; GO:0005856; GO:0043583; GO:0032401; GO:0008057; GO:0031941; GO:0002089; GO:0015280; GO:0032438; GO:0005874; GO:0030835; GO:0043025; GO:0005923 P16333 actin filament binding; apical plasma membrane; apical protein localization; beta-catenin binding; brain development; cell cortex; cell migration; cell-cell adherens junction; cell-cell junction maintenance; cellular pigment accumulation; cytoskeleton; ear development; establishment of melanosome localization; eye pigment granule organization; filamentous actin; lens morphogenesis in camera-type eye; ligand-gated sodium channel activity; melanosome organization; microtubule; negative regulation of actin filament depolymerization; neuronal cell body; tight junction IPR014800; IPR014799; IPR001478; IPR027686; IPR027685; Protein Shroom2 (Apical-like protein) (Protein APXL) SHROOM2 APXL Homo sapiens (Human) TR41476_c1_g1_i2 A2TLM1 RPIA_PIG 1.00E-99 GO:0009052; GO:0004751 "pentose-phosphate shunt, non-oxidative branch; ribose-5-phosphate isomerase activity" IPR004788; IPR020672; Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. Ribose-5-phosphate isomerase (EC 5.3.1.6) (Phosphoriboisomerase) RPIA Sus scrofa (Pig) TR41476_c1_g2_i1 P08548 LIN1_NYCCO 2.00E-27 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR41479_c2_g1_i1 O00764 PDXK_HUMAN 8.00E-117 GO:0005524; GO:0008283; GO:0005829; GO:0031403; GO:0000287; GO:0005634; GO:0030955; GO:0042803; GO:0009443; GO:0008478; GO:0030170; GO:0042823; GO:0031402; GO:0042816; GO:0008270 ATP binding; cell proliferation; cytosol; lithium ion binding; magnesium ion binding; nucleus; potassium ion binding; protein homodimerization activity; pyridoxal 5'-phosphate salvage; pyridoxal kinase activity; pyridoxal phosphate binding; pyridoxal phosphate biosynthetic process; sodium ion binding; vitamin B6 metabolic process; zinc ion binding IPR011611; IPR004625; Pyridoxal kinase (EC 2.7.1.35) (Pyridoxine kinase) PDXK C21orf124 C21orf97 PKH PNK PRED79 Homo sapiens (Human) TR41479_c2_g1_i4 P53727 BUD17_YEAST 5.00E-41 GO:0005524; GO:0007049; GO:0005737; GO:0046872; GO:0005634; GO:0009443; GO:0008478; GO:0042823 ATP binding; cell cycle; cytoplasm; metal ion binding; nucleus; pyridoxal 5'-phosphate salvage; pyridoxal kinase activity; pyridoxal phosphate biosynthetic process IPR013749; IPR004625; Putative pyridoxal kinase BUD17 (EC 2.7.1.35) (Bud site selection protein 17) BUD17 YNR027W N3250 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41479_c2_g1_i6 P82197 PDXK_SHEEP 2.00E-112 GO:0005524; GO:0005737; GO:0046872; GO:0009443; GO:0008478 ATP binding; cytoplasm; metal ion binding; pyridoxal 5'-phosphate salvage; pyridoxal kinase activity IPR011611; IPR004625; Pyridoxal kinase (EC 2.7.1.35) (Pyridoxine kinase) PDXK PKH Ovis aries (Sheep) TR41479_c2_g1_i8 P53727 BUD17_YEAST 2.00E-40 GO:0005524; GO:0007049; GO:0005737; GO:0046872; GO:0005634; GO:0009443; GO:0008478; GO:0042823 ATP binding; cell cycle; cytoplasm; metal ion binding; nucleus; pyridoxal 5'-phosphate salvage; pyridoxal kinase activity; pyridoxal phosphate biosynthetic process IPR013749; IPR004625; Putative pyridoxal kinase BUD17 (EC 2.7.1.35) (Bud site selection protein 17) BUD17 YNR027W N3250 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41479_c2_g1_i9 O00764 PDXK_HUMAN 2.00E-113 GO:0005524; GO:0008283; GO:0005829; GO:0031403; GO:0000287; GO:0005634; GO:0030955; GO:0042803; GO:0009443; GO:0008478; GO:0030170; GO:0042823; GO:0031402; GO:0042816; GO:0008270 ATP binding; cell proliferation; cytosol; lithium ion binding; magnesium ion binding; nucleus; potassium ion binding; protein homodimerization activity; pyridoxal 5'-phosphate salvage; pyridoxal kinase activity; pyridoxal phosphate binding; pyridoxal phosphate biosynthetic process; sodium ion binding; vitamin B6 metabolic process; zinc ion binding IPR011611; IPR004625; Pyridoxal kinase (EC 2.7.1.35) (Pyridoxine kinase) PDXK C21orf124 C21orf97 PKH PNK PRED79 Homo sapiens (Human) TR41480_c1_g1_i1 Q9Y597 KCTD3_HUMAN 0 GO:0051260 protein homooligomerization IPR000210; IPR011333; IPR003131; IPR015943; IPR001680; IPR019775; IPR017986; BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) KCTD3 Homo sapiens (Human) TR41480_c1_g1_i2 Q8N5Z5 KCD17_HUMAN 2.00E-16 GO:0051260 Itself; Q9H5I1 protein homooligomerization IPR000210; IPR011333; IPR003131; BTB/POZ domain-containing protein KCTD17 KCTD17 Homo sapiens (Human) TR41483_c0_g1_i1 P31335 PUR9_CHICK 0 GO:0006189; GO:0003937; GO:0005829; GO:0004643; GO:0006144 'de novo' IMP biosynthetic process; IMP cyclohydrolase activity; cytosol; phosphoribosylaminoimidazolecarboxamide formyltransferase activity; purine nucleobase metabolic process IPR024051; IPR024050; IPR002695; IPR016193; IPR011607; Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1. Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)] ATIC PURH Gallus gallus (Chicken) TR41485_c0_g1_i1 Q86B91 TINC_DROME 6.00E-19 GO:0016021; GO:0042478 integral to membrane; regulation of eye photoreceptor cell development Protein tincar tinc CG31247 Drosophila melanogaster (Fruit fly) TR41486_c0_g1_i1 P70920 ACON_BRAJA 3.00E-54 GO:0051539; GO:0003994; GO:0046872; GO:0006099 "4 iron, 4 sulfur cluster binding; aconitate hydratase activity; metal ion binding; tricarboxylic acid cycle" IPR015931; IPR015937; IPR001030; IPR015928; IPR006249; IPR015934; IPR015932; IPR018136; IPR000573; Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. Aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) acnA bll0466 Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110) TR41486_c0_g1_i2 Q99KI0 ACON_MOUSE 0 GO:0051538; GO:0051539; GO:0003994; GO:0006101; GO:0005506; GO:0006102; GO:0005739; GO:0005634; GO:0006099 "3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity; citrate metabolic process; iron ion binding; isocitrate metabolic process; mitochondrion; nucleus; tricarboxylic acid cycle" IPR015931; IPR015937; IPR001030; IPR015928; IPR015932; IPR018136; IPR006248; IPR000573; Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. "Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)" Aco2 Mus musculus (Mouse) TR41486_c0_g1_i3 Q68VV0 ACON_RICTY 5.00E-48 GO:0051539; GO:0003994; GO:0046872; GO:0006099 "4 iron, 4 sulfur cluster binding; aconitate hydratase activity; metal ion binding; tricarboxylic acid cycle" IPR015931; IPR015937; IPR001030; IPR015928; IPR006249; IPR015934; IPR015932; IPR018136; IPR000573; Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. Aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) acnA RT0786 Rickettsia typhi (strain ATCC VR-144 / Wilmington) TR41486_c0_g1_i4 P70920 ACON_BRAJA 2.00E-54 GO:0051539; GO:0003994; GO:0046872; GO:0006099 "4 iron, 4 sulfur cluster binding; aconitate hydratase activity; metal ion binding; tricarboxylic acid cycle" IPR015931; IPR015937; IPR001030; IPR015928; IPR006249; IPR015934; IPR015932; IPR018136; IPR000573; Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. Aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) acnA bll0466 Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110) TR41486_c0_g1_i5 Q99KI0 ACON_MOUSE 0 GO:0051538; GO:0051539; GO:0003994; GO:0006101; GO:0005506; GO:0006102; GO:0005739; GO:0005634; GO:0006099 "3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity; citrate metabolic process; iron ion binding; isocitrate metabolic process; mitochondrion; nucleus; tricarboxylic acid cycle" IPR015931; IPR015937; IPR001030; IPR015928; IPR015932; IPR018136; IPR006248; IPR000573; Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. "Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)" Aco2 Mus musculus (Mouse) TR41490_c0_g2_i1 Q9TU53 CUBN_CANFA 0 GO:0005509; GO:0008203; GO:0031419; GO:0010008; GO:0005765; GO:0015031 calcium ion binding; cholesterol metabolic process; cobalamin binding; endosome membrane; lysosomal membrane; protein transport IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR009030; Cubilin CUBN Canis familiaris (Dog) (Canis lupus familiaris) TR41490_c0_g3_i2 Q99J86 ATRN_RAT 2.00E-08 GO:0030246; GO:0021549; GO:0005737; GO:0005615; GO:0006954; GO:0016021; GO:0042552; GO:0043473; GO:0005886; GO:0004872; GO:0040014; GO:0006979 carbohydrate binding; cerebellum development; cytoplasm; extracellular space; inflammatory response; integral to membrane; myelination; pigmentation; plasma membrane; receptor activity; regulation of multicellular organism growth; response to oxidative stress IPR001304; IPR016186; IPR016187; IPR000859; IPR000742; IPR013032; IPR002049; IPR015915; IPR006652; IPR016201; IPR002165; Attractin (Protein zitter) Atrn Rattus norvegicus (Rat) TR41490_c0_g4_i1 P79953 OVCH2_XENLA 3.00E-19 GO:0005576; GO:0046872; GO:0006508; GO:0004252 extracellular region; metal ion binding; proteolysis; serine-type endopeptidase activity IPR000859; IPR001254; IPR018114; IPR001314; IPR009003; Ovochymase-2 (EC 3.4.21.120) (Oviductal protease) (Oviductin) ovch2 ovtn Xenopus laevis (African clawed frog) TR41490_c1_g1_i1 Q96PZ7 CSMD1_HUMAN 1.00E-19 GO:0016021 integral to membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 1 (CUB and sushi multiple domains protein 1) CSMD1 KIAA1890 UNQ5952/PRO19863 Homo sapiens (Human) TR41491_c0_g1_i1 Q562C7 K0020_RAT 4.00E-12 GO:0003723; GO:0005730 RNA binding; nucleolus IPR011989; IPR016024; IPR012959; IPR001313; Pumilio domain-containing protein KIAA0020 homolog Rattus norvegicus (Rat) TR41491_c0_g3_i1 Q15397 K0020_HUMAN 9.00E-68 GO:0003723; GO:0005783; GO:0005730 RNA binding; endoplasmic reticulum; nucleolus IPR011989; IPR016024; IPR012959; IPR001313; Pumilio domain-containing protein KIAA0020 (HBV X-transactivated gene 5 protein) (HBV XAg-transactivated protein 5) (Minor histocompatibility antigen HA-8) (HLA-HA8) KIAA0020 XTP5 Homo sapiens (Human) TR41492_c3_g1_i1 P12659 HCYA_ENTDO 1.00E-06 GO:0046872; GO:0055114; GO:0016491; GO:0005344 metal ion binding; oxidation-reduction process; oxidoreductase activity; oxygen transporter activity IPR002227; IPR008922; "Hemocyanin A-type, units Ode to Odg (Fragment)" Enteroctopus dofleini (Giant octopus) (Octopus dofleini) TR41492_c3_g1_i2 P33180 TYRO_RHIML 6.00E-07 GO:0042438; GO:0046872; GO:0004503 melanin biosynthetic process; metal ion binding; monophenol monooxygenase activity IPR002227; IPR008922; Tyrosinase (EC 1.14.18.1) (Monophenol monooxygenase) mepA melA Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) TR41492_c3_g2_i1 B1VTI5 GRIF_STRGG 2.00E-10 GO:0005507; GO:0050149 copper ion binding; o-aminophenol oxidase activity IPR002227; IPR008922; O-aminophenol oxidase (EC 1.10.3.4) (Grixazone biosynthesis protein F) (Ortho-aminophenol oxidase) griF SGR_4246 Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) TR41492_c3_g2_i3 P86952 TYRO_PINMA 3.00E-49 GO:0005576; GO:0046872; GO:0055114; GO:0016491 extracellular region; metal ion binding; oxidation-reduction process; oxidoreductase activity IPR002227; IPR008922; Tyrosinase-like protein (Tyrosinase-2) Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) TR41492_c3_g2_i6 P56826 HCYG_SEPOF 4.00E-07 GO:0046872; GO:0055114; GO:0016491; GO:0005344 metal ion binding; oxidation-reduction process; oxidoreductase activity; oxygen transporter activity IPR002227; IPR008922; "Hemocyanin, units G and H (Fragments)" Sepia officinalis (Common cuttlefish) TR41493_c2_g2_i3 Q2YDN4 CC105_BOVIN 9.00E-18 GO:0005874; GO:0000226 microtubule; microtubule cytoskeleton organization IPR000435; Coiled-coil domain-containing protein 105 CCDC105 Bos taurus (Bovine) TR41497_c1_g2_i1 Q05A80 CAPR2_MOUSE 2.00E-06 GO:0003723; GO:0005739; GO:0030308; GO:0017148; GO:0050775; GO:0061003 RNA binding; mitochondrion; negative regulation of cell growth; negative regulation of translation; positive regulation of dendrite morphogenesis; positive regulation of dendritic spine morphogenesis IPR001073; IPR022070; IPR008983; Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (RNA granule protein 140) Caprin2 C1qdc1 Kiaa1873 Rng140 Mus musculus (Mouse) TR41498_c1_g1_i1 Q923I8 CRY2_RAT 0 GO:0003913; GO:0006281; GO:0071949; GO:0007623; GO:0005737; GO:0005634; GO:0009881; GO:0018298; GO:0006355; GO:0006351 "DNA photolyase activity; DNA repair; FAD binding; circadian rhythm; cytoplasm; nucleus; photoreceptor activity; protein-chromophore linkage; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006050; IPR005101; IPR014729; Cryptochrome-2 Cry2 Rattus norvegicus (Rat) TR41498_c1_g1_i3 Q6ZZY0 CRY1_SYLBO 0 GO:0003913; GO:0006281; GO:0005737; GO:0000166; GO:0005634; GO:0009881; GO:0018298; GO:0006355; GO:0048511; GO:0006351 "DNA photolyase activity; DNA repair; cytoplasm; nucleotide binding; nucleus; photoreceptor activity; protein-chromophore linkage; regulation of transcription, DNA-dependent; rhythmic process; transcription, DNA-dependent" IPR006050; IPR005101; IPR014729; Cryptochrome-1 CRY1 Sylvia borin (Garden warbler) TR41499_c0_g2_i2 Q9BR01 ST4A1_HUMAN 4.00E-62 GO:0050427; GO:0005829; GO:0008202; GO:0008146; GO:0006805 Q13526 3'-phosphoadenosine 5'-phosphosulfate metabolic process; cytosol; steroid metabolic process; sulfotransferase activity; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase 4A1 (ST4A1) (EC 2.8.2.-) (Brain sulfotransferase-like protein) (hBR-STL) (hBR-STL-1) (Nervous system sulfotransferase) (NST) SULT4A1 SULTX3 Homo sapiens (Human) TR41499_c0_g2_i4 O75897 ST1C4_HUMAN 2.00E-60 GO:0050427; GO:0005829; GO:0051923; GO:0008146; GO:0006805 3'-phosphoadenosine 5'-phosphosulfate metabolic process; cytosol; sulfation; sulfotransferase activity; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.-) (Sulfotransferase 1C2) (SULT1C#2) SULT1C4 SULT1C2 Homo sapiens (Human) TR41499_c0_g2_i6 Q9BR01 ST4A1_HUMAN 4.00E-62 GO:0050427; GO:0005829; GO:0008202; GO:0008146; GO:0006805 Q13526 3'-phosphoadenosine 5'-phosphosulfate metabolic process; cytosol; steroid metabolic process; sulfotransferase activity; xenobiotic metabolic process IPR027417; IPR000863; Sulfotransferase 4A1 (ST4A1) (EC 2.8.2.-) (Brain sulfotransferase-like protein) (hBR-STL) (hBR-STL-1) (Nervous system sulfotransferase) (NST) SULT4A1 SULTX3 Homo sapiens (Human) TR41499_c0_g2_i7 P49891 ST1E1_MOUSE 1.00E-48 GO:0005737; GO:0008210; GO:0004304; GO:0007565; GO:0005496; GO:0050294 cytoplasm; estrogen metabolic process; estrone sulfotransferase activity; female pregnancy; steroid binding; steroid sulfotransferase activity IPR027417; IPR000863; "Estrogen sulfotransferase, testis isoform (EC 2.8.2.4) (Sulfotransferase 1E1) (ST1E1) (Sulfotransferase, estrogen-preferring)" Sult1e1 Ste Mus musculus (Mouse) TR41500_c0_g1_i1 O75096 LRP4_HUMAN 6.00E-55 GO:0016055; GO:0005509; GO:0030154; GO:0009953; GO:0042733; GO:0006897; GO:0030198; GO:0001942; GO:0016021; GO:0001822; GO:0090090; GO:0030279; GO:0042475; GO:0005886; GO:0009954; GO:0043113; GO:0001932; GO:0051124 Wnt receptor signaling pathway; calcium ion binding; cell differentiation; dorsal/ventral pattern formation; embryonic digit morphogenesis; endocytosis; extracellular matrix organization; hair follicle development; integral to membrane; kidney development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of ossification; odontogenesis of dentin-containing tooth; plasma membrane; proximal/distal pattern formation; receptor clustering; regulation of protein phosphorylation; synaptic growth at neuromuscular junction IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) TR41500_c0_g1_i4 O75096 LRP4_HUMAN 3.00E-55 GO:0016055; GO:0005509; GO:0030154; GO:0009953; GO:0042733; GO:0006897; GO:0030198; GO:0001942; GO:0016021; GO:0001822; GO:0090090; GO:0030279; GO:0042475; GO:0005886; GO:0009954; GO:0043113; GO:0001932; GO:0051124 Wnt receptor signaling pathway; calcium ion binding; cell differentiation; dorsal/ventral pattern formation; embryonic digit morphogenesis; endocytosis; extracellular matrix organization; hair follicle development; integral to membrane; kidney development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of ossification; odontogenesis of dentin-containing tooth; plasma membrane; proximal/distal pattern formation; receptor clustering; regulation of protein phosphorylation; synaptic growth at neuromuscular junction IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) TR41501_c0_g3_i2 P28648 CD63_RAT 1.00E-31 GO:0030855; GO:0016021; GO:0005765; GO:0005764; GO:0010633; GO:0005886; GO:0045785; GO:0045807; GO:0043234; GO:0032403; GO:0030658 Q03348; Q9WUD9 epithelial cell differentiation; integral to membrane; lysosomal membrane; lysosome; negative regulation of epithelial cell migration; plasma membrane; positive regulation of cell adhesion; positive regulation of endocytosis; protein complex; protein complex binding; transport vesicle membrane IPR000301; IPR018499; IPR018503; IPR008952; CD63 antigen (Mast cell antigen AD1) (CD antigen CD63) Cd63 Rattus norvegicus (Rat) TR41501_c0_g3_i3 Q6AYR9 TSN1_RAT 2.00E-17 GO:0016021; GO:0005765 integral to membrane; lysosomal membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-1 (Tspan-1) Tspan1 Rattus norvegicus (Rat) TR41501_c0_g3_i5 Q9JJW1 TSN2_RAT 2.00E-09 GO:0007420; GO:0016021; GO:0043209 brain development; integral to membrane; myelin sheath IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-2 (Tspan-2) Tspan2 Rattus norvegicus (Rat) TR41502_c0_g1_i3 Q9NRY5 F1142_HUMAN 9.00E-40 GO:0017076 purine nucleotide binding IPR007998; Protein FAM114A2 FAM114A2 C5orf3 Homo sapiens (Human) TR41502_c0_g2_i2 Q9D281 NXP20_MOUSE 8.00E-26 GO:0005737 cytoplasm IPR007998; Protein Noxp20 (Nervous system overexpressed protein 20) (Protein FAM114A1) Fam114a1 Noxp20 Mus musculus (Mouse) TR41503_c0_g1_i3 Q7ZUC7 PGES2_DANRE 1.00E-48 GO:0045454; GO:0009055; GO:0016021; GO:0001516; GO:0050220; GO:0015035 cell redox homeostasis; electron carrier activity; integral to membrane; prostaglandin biosynthetic process; prostaglandin-E synthase activity; protein disulfide oxidoreductase activity IPR011767; IPR002109; IPR010987; IPR012336; Lipid metabolism; prostaglandin biosynthesis. Prostaglandin E synthase 2 (EC 4.1.2.-) (EC 5.3.99.3) (Microsomal prostaglandin E synthase 2) (mPGES-2) ptges2 pges2 ptgesl Danio rerio (Zebrafish) (Brachydanio rerio) TR41503_c0_g1_i5 Q9H7Z7 PGES2_HUMAN 3.00E-51 GO:0003677; GO:0000139; GO:0045454; GO:0005829; GO:0009055; GO:0016021; GO:0005739; GO:0005634; GO:0048471; GO:0045893; GO:0001516; GO:0050220; GO:0015035; GO:0046903 "DNA binding; Golgi membrane; cell redox homeostasis; cytosol; electron carrier activity; integral to membrane; mitochondrion; nucleus; perinuclear region of cytoplasm; positive regulation of transcription, DNA-dependent; prostaglandin biosynthetic process; prostaglandin-E synthase activity; protein disulfide oxidoreductase activity; secretion" IPR002109; IPR010987; IPR004045; IPR012336; Lipid metabolism; prostaglandin biosynthesis. Prostaglandin E synthase 2 (EC 4.1.2.-) (EC 5.3.99.3) (Microsomal prostaglandin E synthase 2) (mPGES-2) [Cleaved into: Prostaglandin E synthase 2 truncated form] PTGES2 C9orf15 PGES2 Homo sapiens (Human) TR41505_c2_g1_i1 O54781 SRPK2_MOUSE 3.00E-115 GO:0071889; GO:0005524; GO:0001525; GO:0030154; GO:0005737; GO:0007243; GO:0000287; GO:0045071; GO:0035063; GO:0005634; GO:0045787; GO:0008284; GO:0010628; GO:0043525; GO:0045070; GO:0004674; GO:0000245 Q07955 14-3-3 protein binding; ATP binding; angiogenesis; cell differentiation; cytoplasm; intracellular protein kinase cascade; magnesium ion binding; negative regulation of viral genome replication; nuclear speck organization; nucleus; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of neuron apoptotic process; positive regulation of viral genome replication; protein serine/threonine kinase activity; spliceosomal complex assembly IPR011009; IPR000719; IPR017441; IPR008271; SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] Srpk2 Mus musculus (Mouse) TR41505_c2_g1_i2 Q5RD27 SRPK1_PONAB 1.00E-105 GO:0005524; GO:0008380; GO:0030154; GO:0007059; GO:0005737; GO:0005783; GO:0007243; GO:0006397; GO:0000287; GO:0016363; GO:0005634; GO:0004674; GO:0050684 ATP binding; RNA splicing; cell differentiation; chromosome segregation; cytoplasm; endoplasmic reticulum; intracellular protein kinase cascade; mRNA processing; magnesium ion binding; nuclear matrix; nucleus; protein serine/threonine kinase activity; regulation of mRNA processing IPR011009; IPR000719; IPR017441; IPR008271; SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) SRPK1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41505_c2_g1_i4 O54781 SRPK2_MOUSE 2.00E-115 GO:0071889; GO:0005524; GO:0001525; GO:0030154; GO:0005737; GO:0007243; GO:0000287; GO:0045071; GO:0035063; GO:0005634; GO:0045787; GO:0008284; GO:0010628; GO:0043525; GO:0045070; GO:0004674; GO:0000245 Q07955 14-3-3 protein binding; ATP binding; angiogenesis; cell differentiation; cytoplasm; intracellular protein kinase cascade; magnesium ion binding; negative regulation of viral genome replication; nuclear speck organization; nucleus; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of neuron apoptotic process; positive regulation of viral genome replication; protein serine/threonine kinase activity; spliceosomal complex assembly IPR011009; IPR000719; IPR017441; IPR008271; SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] Srpk2 Mus musculus (Mouse) TR41506_c6_g1_i2 Q9R0D8 WDR54_MOUSE 9.00E-75 IPR015943; IPR001680; IPR017986; WD repeat-containing protein 54 Wdr54 D3Mm3e Mus musculus (Mouse) TR41507_c4_g1_i1 Q08AE8 SPIR1_HUMAN 5.00E-48 GO:0005794; GO:0048193; GO:0005938; GO:0036089; GO:0030659; GO:0005856; GO:0051295; GO:0070649; GO:0046907; GO:0048471; GO:0005886; GO:0040038; GO:0015031; GO:0016192 P27348 Golgi apparatus; Golgi vesicle transport; cell cortex; cleavage furrow formation; cytoplasmic vesicle membrane; cytoskeleton; establishment of meiotic spindle localization; formin-nucleated actin cable assembly; intracellular transport; perinuclear region of cytoplasm; plasma membrane; polar body extrusion after meiotic divisions; protein transport; vesicle-mediated transport IPR011019; IPR011011; IPR013083; Protein spire homolog 1 (Spir-1) SPIRE1 KIAA1135 SPIR1 Homo sapiens (Human) TR41507_c4_g1_i2 Q08AE8 SPIR1_HUMAN 5.00E-48 GO:0005794; GO:0048193; GO:0005938; GO:0036089; GO:0030659; GO:0005856; GO:0051295; GO:0070649; GO:0046907; GO:0048471; GO:0005886; GO:0040038; GO:0015031; GO:0016192 P27348 Golgi apparatus; Golgi vesicle transport; cell cortex; cleavage furrow formation; cytoplasmic vesicle membrane; cytoskeleton; establishment of meiotic spindle localization; formin-nucleated actin cable assembly; intracellular transport; perinuclear region of cytoplasm; plasma membrane; polar body extrusion after meiotic divisions; protein transport; vesicle-mediated transport IPR011019; IPR011011; IPR013083; Protein spire homolog 1 (Spir-1) SPIRE1 KIAA1135 SPIR1 Homo sapiens (Human) TR41507_c4_g1_i3 Q52KF3 SPIR1_MOUSE 2.00E-26 GO:0005794; GO:0048193; GO:0005938; GO:0036089; GO:0030659; GO:0005856; GO:0005829; GO:0051295; GO:0070649; GO:0048471; GO:0005886; GO:0040038; GO:0015031 Golgi apparatus; Golgi vesicle transport; cell cortex; cleavage furrow formation; cytoplasmic vesicle membrane; cytoskeleton; cytosol; establishment of meiotic spindle localization; formin-nucleated actin cable assembly; perinuclear region of cytoplasm; plasma membrane; polar body extrusion after meiotic divisions; protein transport IPR011019; IPR011011; Protein spire homolog 1 Spire1 Mus musculus (Mouse) TR41507_c4_g1_i6 Q8WWL2 SPIR2_HUMAN 1.00E-40 GO:0005938; GO:0032154; GO:0036089; GO:0030659; GO:0005856; GO:0005829; GO:0051295; GO:0070649; GO:0046907; GO:0048471; GO:0005886; GO:0040038; GO:0015031; GO:0016192 cell cortex; cleavage furrow; cleavage furrow formation; cytoplasmic vesicle membrane; cytoskeleton; cytosol; establishment of meiotic spindle localization; formin-nucleated actin cable assembly; intracellular transport; perinuclear region of cytoplasm; plasma membrane; polar body extrusion after meiotic divisions; protein transport; vesicle-mediated transport IPR011019; IPR003124; IPR011011; IPR013083; Protein spire homolog 2 (Spir-2) SPIRE2 KIAA1832 SPIR2 Homo sapiens (Human) TR41508_c3_g1_i1 Q7M3S9 RNGB_DICDI 8.00E-11 GO:0005737; GO:0008270 cytoplasm; zinc ion binding IPR015915; IPR006652; IPR001841; IPR013083; RING finger protein B (Protein rngB) rngB DDB_G0268860 Dictyostelium discoideum (Slime mold) TR41508_c3_g1_i10 Q24306 IAP1_DROME 1.00E-27 GO:0019788; GO:0016055; GO:0048800; GO:0007298; GO:0008407; GO:0004869; GO:0005737; GO:0008354; GO:0097340; GO:1990001; GO:0043066; GO:0046673; GO:0005634; GO:0090263; GO:0031398; GO:0042787; GO:0045035; GO:0007289; GO:0004842; GO:0008270 P25843; Q86PE7; Q9XYF4; Q24475; Q24106 NEDD8 ligase activity; Wnt receptor signaling pathway; antennal morphogenesis; border follicle cell migration; chaeta morphogenesis; cysteine-type endopeptidase inhibitor activity; cytoplasm; germ cell migration; inhibition of cysteine-type endopeptidase activity; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of compound eye retinal cell programmed cell death; nucleus; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; sensory organ precursor cell division; spermatid nucleus differentiation; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; Apoptosis 1 inhibitor (EC 6.3.2.-) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (dIAP1) (Protein thread) th Iap1 CG12284 Drosophila melanogaster (Fruit fly) TR41508_c3_g1_i12 Q9VUX2 MIB_DROME 8.00E-09 GO:0007219; GO:0045179; GO:0005829; GO:0006897; GO:0046331; GO:0045747; GO:0008104; GO:0007423; GO:0004842; GO:0008270 Notch signaling pathway; apical cortex; cytosol; endocytosis; lateral inhibition; positive regulation of Notch signaling pathway; protein localization; sensory organ development; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase mind-bomb (EC 6.3.2.-) (Mind bomb homolog) (D-mib) mib1 mind-bomb CG5841 Drosophila melanogaster (Fruit fly) TR41508_c3_g1_i13 Q6TEM9 MYLIA_DANRE 6.00E-10 GO:0005737; GO:0005856; GO:0005829; GO:0007369; GO:0016874; GO:0030178; GO:0016567; GO:0008270 cytoplasm; cytoskeleton; cytosol; gastrulation; ligase activity; negative regulation of Wnt receptor signaling pathway; protein ubiquitination; zinc ion binding IPR019749; IPR019750; IPR014352; IPR019748; IPR000299; IPR018979; IPR011993; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MYLIP-A (EC 6.3.2.-) (Myosin regulatory light chain-interacting protein A) (MIR-A) mylipa mir mylip si:ch211-266j17.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR41508_c3_g1_i14 Q8JHV9 BIR7A_XENLA 4.00E-40 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR41508_c3_g1_i15 A9JTP3 BIRC7_XENTR 4.00E-39 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP) (Embryonic/Egg IAP) (EIAP/XLX) birc7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41508_c3_g1_i16 Q6R7C4 IAP4_OSHVF 2.00E-11 GO:0008270 zinc ion binding IPR001370; IPR001841; IPR013083; Putative apoptosis inhibitor ORF106 ORF106 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) TR41508_c3_g1_i20 O62640 PIAP_PIG 3.00E-42 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR41508_c3_g1_i3 Q9VUX2 MIB_DROME 1.00E-08 GO:0007219; GO:0045179; GO:0005829; GO:0006897; GO:0046331; GO:0045747; GO:0008104; GO:0007423; GO:0004842; GO:0008270 Notch signaling pathway; apical cortex; cytosol; endocytosis; lateral inhibition; positive regulation of Notch signaling pathway; protein localization; sensory organ development; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase mind-bomb (EC 6.3.2.-) (Mind bomb homolog) (D-mib) mib1 mind-bomb CG5841 Drosophila melanogaster (Fruit fly) TR41508_c3_g1_i4 Q8JHV9 BIR7A_XENLA 2.00E-40 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR41508_c3_g1_i6 O62640 PIAP_PIG 2.00E-42 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR41508_c3_g1_i7 A9JTP3 BIRC7_XENTR 2.00E-39 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP) (Embryonic/Egg IAP) (EIAP/XLX) birc7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41508_c3_g1_i9 Q6TEM9 MYLIA_DANRE 2.00E-09 GO:0005737; GO:0005856; GO:0005829; GO:0007369; GO:0016874; GO:0030178; GO:0016567; GO:0008270 cytoplasm; cytoskeleton; cytosol; gastrulation; ligase activity; negative regulation of Wnt receptor signaling pathway; protein ubiquitination; zinc ion binding IPR019749; IPR019750; IPR014352; IPR019748; IPR000299; IPR018979; IPR011993; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MYLIP-A (EC 6.3.2.-) (Myosin regulatory light chain-interacting protein A) (MIR-A) mylipa mir mylip si:ch211-266j17.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR41510_c2_g1_i2 Q9DGQ7 CDC37_TETFL 8.00E-124 GO:0005737 cytoplasm IPR004918; IPR013873; IPR013874; IPR013855; Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) cdc37 Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis) TR41510_c2_g1_i3 A7YY97 CD37L_DANRE 1.00E-45 GO:0005737 cytoplasm IPR004918; IPR013873; IPR013874; Hsp90 co-chaperone Cdc37-like 1 cdc37l1 zgc:171475 Danio rerio (Zebrafish) (Brachydanio rerio) TR41510_c2_g1_i5 A7YY97 CD37L_DANRE 1.00E-45 GO:0005737 cytoplasm IPR004918; IPR013873; IPR013874; Hsp90 co-chaperone Cdc37-like 1 cdc37l1 zgc:171475 Danio rerio (Zebrafish) (Brachydanio rerio) TR41510_c2_g1_i7 Q9CZP7 CD37L_MOUSE 8.00E-36 GO:0005737 cytoplasm IPR004918; IPR013874; Hsp90 co-chaperone Cdc37-like 1 Cdc37l1 Mus musculus (Mouse) TR41510_c2_g1_i8 Q9DGQ7 CDC37_TETFL 4.00E-121 GO:0005737 cytoplasm IPR004918; IPR013873; IPR013874; IPR013855; Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) cdc37 Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis) TR41510_c2_g1_i9 Q9DGQ7 CDC37_TETFL 3.00E-122 GO:0005737 cytoplasm IPR004918; IPR013873; IPR013874; IPR013855; Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) cdc37 Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis) TR41511_c1_g2_i1 P18709 VITA2_XENLA 8.00E-07 GO:0005319; GO:0045735 lipid transporter activity; nutrient reservoir activity IPR015819; IPR001747; IPR015816; IPR015258; IPR015255; IPR015817; IPR015818; IPR011030; IPR001846; Vitellogenin-A2 (VTG A2) [Cleaved into: Lipovitellin I; Lipovitellin II; Phosvitin] Xenopus laevis (African clawed frog) TR41511_c1_g2_i2 Q94637 VIT6_OSCBR 2.00E-11 GO:0005576; GO:0005319; GO:0045735 extracellular region; lipid transporter activity; nutrient reservoir activity IPR015819; IPR001747; IPR015816; IPR015255; IPR015817; IPR015818; IPR011030; IPR001846; Vitellogenin-6 (OTI-VIT-6) [Cleaved into: VT3; VT2] vit-6 Oscheius tipulae TR41513_c1_g1_i1 Q0VBY1 ODF2L_BOVIN 1.00E-16 IPR026102; IPR026099; Outer dense fiber protein 2-like ODF2L Bos taurus (Bovine) TR41513_c1_g1_i2 A3KGV1 ODFP2_MOUSE 5.00E-71 GO:0005814; GO:0005929; GO:0005874; GO:0007275; GO:0001520; GO:0007286; GO:0000922; GO:0005200 centriole; cilium; microtubule; multicellular organismal development; outer dense fiber; spermatid development; spindle pole; structural constituent of cytoskeleton IPR026099; Outer dense fiber protein 2 (84 kDa outer dense fiber protein) (Cenexin) (Outer dense fiber of sperm tails protein 2) Odf2 Odf84 Mus musculus (Mouse) TR41515_c0_g2_i2 Q1LX59 C2512_DANRE 3.00E-72 GO:0005789; GO:0006633; GO:0016021; GO:0005506; GO:0004497; GO:0016126 endoplasmic reticulum membrane; fatty acid biosynthetic process; integral to membrane; iron ion binding; monooxygenase activity; sterol biosynthetic process IPR006694; "Cholesterol 25-hydroxylase-like protein 1, member 2 (EC 1.14.99.-)" ch25hl1.2 si:dkey-24l11.9 Danio rerio (Zebrafish) (Brachydanio rerio) TR41515_c2_g1_i1 Q6FIF0 ZFAN6_HUMAN 1.00E-39 GO:0003677; GO:0006915; GO:0071356; GO:0005737; GO:0043066; GO:0031593; GO:0006625; GO:0043122; GO:0008270 Q12933 DNA binding; apoptotic process; cellular response to tumor necrosis factor; cytoplasm; negative regulation of apoptotic process; polyubiquitin binding; protein targeting to peroxisome; regulation of I-kappaB kinase/NF-kappaB cascade; zinc ion binding IPR002653; IPR000058; AN1-type zinc finger protein 6 (Associated with PRK1 protein) (Zinc finger A20 domain-containing protein 3) ZFAND6 AWP1 ZA20D3 HT032 Homo sapiens (Human) TR41515_c2_g1_i2 B5DF11 ZFAN5_RAT 1.00E-35 GO:0003677; GO:0005737; GO:0008270 DNA binding; cytoplasm; zinc ion binding IPR002653; IPR000058; AN1-type zinc finger protein 5 (Zinc finger protein 216) Zfand5 Zfp216 Znf216 Rattus norvegicus (Rat) TR41517_c0_g1_i1 P0C227 GLB_NERAL 4.00E-19 GO:0005576; GO:0020037; GO:0005833; GO:0005506; GO:0019825; GO:0005344 extracellular region; heme binding; hemoglobin complex; iron ion binding; oxygen binding; oxygen transporter activity IPR002336; IPR000971; IPR009050; IPR012292; Globin (Myoglobin) Nerita albicilla (Ox-palate nerite) (Theliostyla albicilla) TR41517_c0_g1_i2 P21197 GLB1_MORMR 7.00E-07 GO:0020037; GO:0005506; GO:0019825; GO:0005344 heme binding; iron ion binding; oxygen binding; oxygen transporter activity IPR000971; IPR009050; IPR012292; IPR013314; Globin-1 (Hemoglobin I) Mordacia mordax (Southern hemisphere lamprey) TR41517_c0_g1_i4 P0C227 GLB_NERAL 1.00E-22 GO:0005576; GO:0020037; GO:0005833; GO:0005506; GO:0019825; GO:0005344 extracellular region; heme binding; hemoglobin complex; iron ion binding; oxygen binding; oxygen transporter activity IPR002336; IPR000971; IPR009050; IPR012292; Globin (Myoglobin) Nerita albicilla (Ox-palate nerite) (Theliostyla albicilla) TR41518_c0_g2_i1 Q3ZBD9 MARE1_BOVIN 8.00E-102 GO:0051301; GO:0030981; GO:0005874; GO:0005815; GO:0051010; GO:0007067; GO:0031115; GO:0035372 cell division; cortical microtubule cytoskeleton; microtubule; microtubule organizing center; microtubule plus-end binding; mitosis; negative regulation of microtubule polymerization; protein localization to microtubule IPR001715; IPR027739; IPR004953; IPR027328; Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) MAPRE1 Bos taurus (Bovine) TR41519_c1_g1_i1 P53760 LCAT_CHICK 2.00E-60 GO:0008203; GO:0005576; GO:0004607 cholesterol metabolic process; extracellular region; phosphatidylcholine-sterol O-acyltransferase activity IPR003386; Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase) (Fragment) LCAT Gallus gallus (Chicken) TR41519_c1_g1_i10 O35573 LCAT_ELIQU 2.00E-35 GO:0008203; GO:0005576; GO:0004607 cholesterol metabolic process; extracellular region; phosphatidylcholine-sterol O-acyltransferase activity IPR003386; Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase) (Fragment) LCAT Eliomys quercinus (Garden dormouse) TR41519_c1_g1_i14 Q675A5 PAG15_RAT 5.00E-66 GO:0008374; GO:0047499; GO:0006672; GO:0005576; GO:0006631; GO:0005764; GO:0005739; GO:0046470 O-acyltransferase activity; calcium-independent phospholipase A2 activity; ceramide metabolic process; extracellular region; fatty acid metabolic process; lysosome; mitochondrion; phosphatidylcholine metabolic process IPR003386; Group XV phospholipase A2 (EC 2.3.1.-) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) Pla2g15 Lypla3 Rattus norvegicus (Rat) TR41519_c1_g1_i15 P53761 LCAT_RABIT 9.00E-54 GO:0008203; GO:0005576; GO:0004607 cholesterol metabolic process; extracellular region; phosphatidylcholine-sterol O-acyltransferase activity IPR003386; Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase) LCAT Oryctolagus cuniculus (Rabbit) TR41519_c1_g1_i2 Q8VEB4 PAG15_MOUSE 3.00E-70 GO:0008374; GO:0047499; GO:0006672; GO:0005576; GO:0006631; GO:0005764; GO:0005739; GO:0046470 O-acyltransferase activity; calcium-independent phospholipase A2 activity; ceramide metabolic process; extracellular region; fatty acid metabolic process; lysosome; mitochondrion; phosphatidylcholine metabolic process IPR003386; Group XV phospholipase A2 (EC 2.3.1.-) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) Pla2g15 Lypla3 Mus musculus (Mouse) TR41519_c1_g1_i3 Q675A5 PAG15_RAT 3.00E-70 GO:0008374; GO:0047499; GO:0006672; GO:0005576; GO:0006631; GO:0005764; GO:0005739; GO:0046470 O-acyltransferase activity; calcium-independent phospholipase A2 activity; ceramide metabolic process; extracellular region; fatty acid metabolic process; lysosome; mitochondrion; phosphatidylcholine metabolic process IPR003386; Group XV phospholipase A2 (EC 2.3.1.-) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) Pla2g15 Lypla3 Rattus norvegicus (Rat) TR41520_c0_g1_i2 P0CE68 NFT1_YEAST 2.00E-35 GO:0005524; GO:0042626; GO:0000329; GO:0016021 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; fungal-type vacuole membrane; integral to membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; ABC transporter NFT1 (New full-length MRP-type transporter 1) NFT1 YKR103W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41520_c0_g2_i1 O15440 MRP5_HUMAN 2.00E-180 GO:0005524; GO:0006200; GO:0042626; GO:0005975; GO:0030213; GO:0005887; GO:0008514 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; carbohydrate metabolic process; hyaluronan biosynthetic process; integral to plasma membrane; organic anion transmembrane transporter activity" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) (pABC11) ABCC5 MRP5 Homo sapiens (Human) TR41520_c0_g2_i2 O15440 MRP5_HUMAN 2.00E-180 GO:0005524; GO:0006200; GO:0042626; GO:0005975; GO:0030213; GO:0005887; GO:0008514 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; carbohydrate metabolic process; hyaluronan biosynthetic process; integral to plasma membrane; organic anion transmembrane transporter activity" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) (pABC11) ABCC5 MRP5 Homo sapiens (Human) TR41520_c0_g3_i2 Q9FVV9 NAP5_ARATH 1.00E-07 GO:0005524; GO:0042626; GO:0016021 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; integral to membrane" IPR011527; IPR003439; IPR027417; Probable non-intrinsic ABC protein 5 (MRP-related protein 2) NAP5 At1g71330 F3I17.2 Arabidopsis thaliana (Mouse-ear cress) TR41521_c0_g1_i1 A0LMC0 PHNW_SYNFM 3.00E-113 GO:0047304; GO:0019700; GO:0030170 2-aminoethylphosphonate-pyruvate transaminase activity; organic phosphonate catabolic process; pyridoxal phosphate binding IPR000192; IPR012703; IPR015424; IPR015421; IPR015422; IPR024169; 2-aminoethylphosphonate--pyruvate transaminase (EC 2.6.1.37) (2-aminoethylphosphonate aminotransferase) (AEP transaminase) (AEPT) phnW Sfum_2895 Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB) TR41521_c0_g2_i1 Q6DFC0 S41A2_XENLA 1.00E-155 GO:0008324; GO:0016021; GO:0005886 cation transmembrane transporter activity; integral to membrane; plasma membrane IPR006667; Solute carrier family 41 member 2 slc41a2 Xenopus laevis (African clawed frog) TR41523_c0_g3_i1 Q9HC24 LFG4_HUMAN 3.00E-75 GO:0000139; GO:0005795; GO:0006915; GO:0016021; GO:0043066; GO:0050848 Golgi membrane; Golgi stack; apoptotic process; integral to membrane; negative regulation of apoptotic process; regulation of calcium-mediated signaling IPR006214; Protein lifeguard 4 (Golgi anti-apoptotic protein) (Protein S1R) (Transmembrane BAX inhibitor motif-containing protein 4) (Z-protein) TMBIM4 GAAP LFG4 CGI-119 Homo sapiens (Human) TR41524_c1_g1_i1 P55786 PSA_HUMAN 5.00E-53 GO:0004177; GO:0002474; GO:0071456; GO:0005829; GO:0008237; GO:0005634; GO:0000209; GO:0006508; GO:0008270 P56537 aminopeptidase activity; antigen processing and presentation of peptide antigen via MHC class I; cellular response to hypoxia; cytosol; metallopeptidase activity; nucleus; protein polyubiquitination; proteolysis; zinc ion binding IPR024571; IPR015568; IPR001930; IPR014782; Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S) NPEPPS PSA Homo sapiens (Human) TR41524_c1_g4_i1 P79171 AMPN_FELCA 1.00E-128 GO:0004177; GO:0001525; GO:0030154; GO:0016021; GO:0008237; GO:0019048; GO:0006508; GO:0009615; GO:0001618; GO:0008270 aminopeptidase activity; angiogenesis; cell differentiation; integral to membrane; metallopeptidase activity; modulation by virus of host morphology or physiology; proteolysis; response to virus; virus receptor activity; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (AP-N) (fAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) ANPEP APN Felis catus (Cat) (Felis silvestris catus) TR41524_c1_g4_i2 Q32LQ0 AMPE_BOVIN 2.00E-130 GO:0016477; GO:0008283; GO:0016021; GO:0070006; GO:0006508; GO:0003081; GO:0008270 cell migration; cell proliferation; integral to membrane; metalloaminopeptidase activity; proteolysis; regulation of systemic arterial blood pressure by renin-angiotensin; zinc ion binding IPR024571; IPR001930; IPR014782; Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (CD antigen CD249) ENPEP Bos taurus (Bovine) TR41524_c1_g4_i3 Q11011 PSA_MOUSE 0 GO:0004177; GO:0005829; GO:0008237; GO:0005634; GO:0006508; GO:0008270 aminopeptidase activity; cytosol; metallopeptidase activity; nucleus; proteolysis; zinc ion binding IPR024571; IPR015568; IPR001930; IPR014782; Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S) Npepps Psa Mus musculus (Mouse) TR41525_c0_g2_i1 Q9JHU4 DYHC1_MOUSE 0 GO:0005524; GO:0006200; GO:0016887; GO:0005794; GO:0005858; GO:0005813; GO:0003341; GO:0005737; GO:0033962; GO:0070062; GO:0030175; GO:0005874; GO:0003777; GO:0034063; GO:0006810 P07141 ATP binding; ATP catabolic process; ATPase activity; Golgi apparatus; axonemal dynein complex; centrosome; cilium movement; cytoplasm; cytoplasmic mRNA processing body assembly; extracellular vesicular exosome; filopodium; microtubule; microtubule motor activity; stress granule assembly; transport IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)" Dync1h1 Dhc1 Dnch1 Dnchc1 Dyhc Mus musculus (Mouse) TR41525_c0_g2_i2 Q9JHU4 DYHC1_MOUSE 0 GO:0005524; GO:0006200; GO:0016887; GO:0005794; GO:0005858; GO:0005813; GO:0003341; GO:0005737; GO:0033962; GO:0070062; GO:0030175; GO:0005874; GO:0003777; GO:0034063; GO:0006810 P07141 ATP binding; ATP catabolic process; ATPase activity; Golgi apparatus; axonemal dynein complex; centrosome; cilium movement; cytoplasm; cytoplasmic mRNA processing body assembly; extracellular vesicular exosome; filopodium; microtubule; microtubule motor activity; stress granule assembly; transport IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)" Dync1h1 Dhc1 Dnch1 Dnchc1 Dyhc Mus musculus (Mouse) TR41525_c0_g2_i3 P45443 DYHC_NEUCR 0 GO:0005524; GO:0006200; GO:0016887; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain, cytoplasmic (Dynein heavy chain, cytosolic) (DYHC)" ro-1 NCU06976 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR41525_c0_g2_i4 Q8IBG1 DYHC1_PLAF7 5.00E-168 GO:0005524; GO:0006200; GO:0016887; GO:0005737; GO:0030286; GO:0005874; GO:0005875; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cytoplasm; dynein complex; microtubule; microtubule associated complex; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; Dynein heavy chain-like protein MAL7P1.162 MAL7P1.162 Plasmodium falciparum (isolate 3D7) TR41525_c0_g2_i5 Q9JHU4 DYHC1_MOUSE 0 GO:0005524; GO:0006200; GO:0016887; GO:0005794; GO:0005858; GO:0005813; GO:0003341; GO:0005737; GO:0033962; GO:0070062; GO:0030175; GO:0005874; GO:0003777; GO:0034063; GO:0006810 P07141 ATP binding; ATP catabolic process; ATPase activity; Golgi apparatus; axonemal dynein complex; centrosome; cilium movement; cytoplasm; cytoplasmic mRNA processing body assembly; extracellular vesicular exosome; filopodium; microtubule; microtubule motor activity; stress granule assembly; transport IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)" Dync1h1 Dhc1 Dnch1 Dnchc1 Dyhc Mus musculus (Mouse) TR41525_c0_g2_i6 Q9JHU4 DYHC1_MOUSE 0 GO:0005524; GO:0006200; GO:0016887; GO:0005794; GO:0005858; GO:0005813; GO:0003341; GO:0005737; GO:0033962; GO:0070062; GO:0030175; GO:0005874; GO:0003777; GO:0034063; GO:0006810 P07141 ATP binding; ATP catabolic process; ATPase activity; Golgi apparatus; axonemal dynein complex; centrosome; cilium movement; cytoplasm; cytoplasmic mRNA processing body assembly; extracellular vesicular exosome; filopodium; microtubule; microtubule motor activity; stress granule assembly; transport IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)" Dync1h1 Dhc1 Dnch1 Dnchc1 Dyhc Mus musculus (Mouse) TR41526_c0_g2_i2 Q96L46 CPNS2_HUMAN 1.00E-17 GO:0005509; GO:0005737; GO:0005886 calcium ion binding; cytoplasm; plasma membrane IPR011992; IPR002048; Calpain small subunit 2 (CSS2) (Calcium-dependent protease small subunit 2) CAPNS2 Homo sapiens (Human) TR41526_c0_g2_i3 Q641Z8 PEF1_RAT 7.00E-53 GO:0005509; GO:0005737; GO:0016020; GO:0051592 calcium ion binding; cytoplasm; membrane; response to calcium ion IPR011992; IPR018247; IPR002048; Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1) Pef1 Rattus norvegicus (Rat) TR41526_c0_g2_i4 Q9UBV8 PEF1_HUMAN 1.00E-54 GO:0005509; GO:0005737; GO:0016020; GO:0051592 Q15038; Q53G59 calcium ion binding; cytoplasm; membrane; response to calcium ion IPR011992; IPR018247; IPR002048; Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1) PEF1 ABP32 UNQ1845/PRO3573 Homo sapiens (Human) TR41526_c0_g2_i5 Q9UBV8 PEF1_HUMAN 6.00E-54 GO:0005509; GO:0005737; GO:0016020; GO:0051592 Q15038; Q53G59 calcium ion binding; cytoplasm; membrane; response to calcium ion IPR011992; IPR018247; IPR002048; Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1) PEF1 ABP32 UNQ1845/PRO3573 Homo sapiens (Human) TR41526_c0_g2_i6 P25070 CML24_ARATH 6.00E-10 GO:0005509; GO:0045087; GO:0048574; GO:0005886; GO:0009909; GO:0080164; GO:0009737; GO:0009646; GO:0009733; GO:0051592; GO:0009409; GO:0009408; GO:0042542; GO:0009612 "calcium ion binding; innate immune response; long-day photoperiodism, flowering; plasma membrane; regulation of flower development; regulation of nitric oxide metabolic process; response to abscisic acid stimulus; response to absence of light; response to auxin stimulus; response to calcium ion; response to cold; response to heat; response to hydrogen peroxide; response to mechanical stimulus" IPR011992; IPR018247; IPR002048; Calcium-binding protein CML24 (Calmodulin-like protein 24) (Touch-induced calmodulin-related protein 2) CML24 TCH2 At5g37770 K22F20.1 Arabidopsis thaliana (Mouse-ear cress) TR41527_c0_g1_i1 Q6ZQK5 ACAP2_MOUSE 0 GO:0008060; GO:1990090; GO:0010008; GO:0005543; GO:0043547; GO:0036010; GO:0032312; GO:0008270 ARF GTPase activator activity; cellular response to nerve growth factor stimulus; endosome membrane; phospholipid binding; positive regulation of GTPase activity; protein localization to endosome; regulation of ARF GTPase activity; zinc ion binding IPR027267; IPR002110; IPR020683; IPR001164; IPR011993; IPR001849; "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2)" Acap2 Centb2 Kiaa0041 Mus musculus (Mouse) TR41527_c0_g1_i2 A5PK26 ACAP1_BOVIN 4.00E-132 GO:0008060; GO:0016787; GO:0005543; GO:0055038; GO:0032312; GO:0004871; GO:0008270 ARF GTPase activator activity; hydrolase activity; phospholipid binding; recycling endosome membrane; regulation of ARF GTPase activity; signal transducer activity; zinc ion binding IPR027267; IPR002110; IPR020683; IPR001164; IPR011993; IPR001849; "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (Centaurin-beta-1) (Cnt-b1)" ACAP1 CENTB1 Bos taurus (Bovine) TR41527_c0_g1_i3 Q5ZK62 ACAP2_CHICK 0 GO:0008060; GO:1990090; GO:0010008; GO:0005543; GO:0043547; GO:0036010; GO:0032312; GO:0008270 ARF GTPase activator activity; cellular response to nerve growth factor stimulus; endosome membrane; phospholipid binding; positive regulation of GTPase activity; protein localization to endosome; regulation of ARF GTPase activity; zinc ion binding IPR027267; IPR002110; IPR020683; IPR001164; IPR011993; IPR001849; "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2)" ACAP2 CENTB2 RCJMB04_12p24 Gallus gallus (Chicken) TR41528_c2_g1_i2 Q9EP86 NPFF1_RAT 1.00E-09 GO:0016021; GO:0008188; GO:0007218; GO:0005886 integral to membrane; neuropeptide receptor activity; neuropeptide signaling pathway; plasma membrane IPR000276; IPR017452; IPR005395; IPR005396; Neuropeptide FF receptor 1 (G-protein coupled receptor 147) (RFamide-related peptide receptor OT7T022) Npffr1 Gpr147 Npff1 Rattus norvegicus (Rat) TR41529_c0_g2_i1 Q95334 AMPE_PIG 0 GO:0016477; GO:0008283; GO:0016021; GO:0070006; GO:0006508; GO:0003081; GO:0008270 cell migration; cell proliferation; integral to membrane; metalloaminopeptidase activity; proteolysis; regulation of systemic arterial blood pressure by renin-angiotensin; zinc ion binding IPR024571; IPR001930; IPR014782; Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (CD antigen CD249) ENPEP Sus scrofa (Pig) TR41529_c0_g2_i2 Q978U3 TRF2_THEVO 2.00E-67 GO:0004177; GO:0005737; GO:0008237; GO:0006508; GO:0008270 aminopeptidase activity; cytoplasm; metallopeptidase activity; proteolysis; zinc ion binding IPR024571; IPR001930; IPR014782; Tricorn protease-interacting factor F2 (EC 3.4.11.-) trf2 TV1322 TVG1363786 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) TR41532_c0_g2_i1 Q8CFH6 SIK2_MOUSE 0 GO:0005524; GO:0005737; GO:0008286; GO:0007243; GO:0000287; GO:0005634; GO:0046777; GO:0004674; GO:0046626 ATP binding; cytoplasm; insulin receptor signaling pathway; intracellular protein kinase cascade; magnesium ion binding; nucleus; protein autophosphorylation; protein serine/threonine kinase activity; regulation of insulin receptor signaling pathway IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR017090; IPR015940; Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) Sik2 Snf1lk2 Mus musculus (Mouse) TR41533_c0_g1_i1 Q28F51 TADBP_XENTR 6.00E-114 GO:0003677; GO:0003723; GO:0008380; GO:0006397; GO:0000166; GO:0005634; GO:0006355; GO:0006351 "DNA binding; RNA binding; RNA splicing; mRNA processing; nucleotide binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR012677; IPR000504; TAR DNA-binding protein 43 (TDP-43) tardbp tdp43 TGas087d21.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41534_c0_g1_i10 Q74ND5 SYP_NANEQ 3.00E-45 GO:0005524; GO:0005737; GO:0004827; GO:0006433 ATP binding; cytoplasm; proline-tRNA ligase activity; prolyl-tRNA aminoacylation IPR002314; IPR006195; IPR004154; IPR002316; IPR004499; IPR016061; IPR017449; Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS) proS NEQ210 Nanoarchaeum equitans (strain Kin4-M) TR41534_c0_g1_i11 Q81IE9 SYP2_BACCR 7.00E-134 GO:0005524; GO:0005737; GO:0004827; GO:0006433 ATP binding; cytoplasm; proline-tRNA ligase activity; prolyl-tRNA aminoacylation IPR002314; IPR006195; IPR004154; IPR002316; IPR004499; IPR016061; IPR017449; Proline--tRNA ligase 2 (EC 6.1.1.15) (Prolyl-tRNA synthetase 2) (ProRS 2) proS2 BC_0439 Bacillus cereus (strain ATCC 14579 / DSM 31) TR41534_c0_g1_i12 P28668 SYEP_DROME 0 GO:0005524; GO:0003723; GO:0005737; GO:0004818; GO:0006424; GO:0004827; GO:0006433 ATP binding; RNA binding; cytoplasm; glutamate-tRNA ligase activity; glutamyl-tRNA aminoacylation; proline-tRNA ligase activity; prolyl-tRNA aminoacylation IPR002314; IPR001412; IPR006195; IPR004154; IPR004526; IPR000924; IPR020061; IPR020058; IPR020059; IPR010987; IPR004499; IPR016061; IPR017449; IPR020056; IPR011035; IPR014729; IPR009068; IPR000738; Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)] Aats-glupro CG5394 Drosophila melanogaster (Fruit fly) TR41534_c0_g1_i3 P28668 SYEP_DROME 0 GO:0005524; GO:0003723; GO:0005737; GO:0004818; GO:0006424; GO:0004827; GO:0006433 ATP binding; RNA binding; cytoplasm; glutamate-tRNA ligase activity; glutamyl-tRNA aminoacylation; proline-tRNA ligase activity; prolyl-tRNA aminoacylation IPR002314; IPR001412; IPR006195; IPR004154; IPR004526; IPR000924; IPR020061; IPR020058; IPR020059; IPR010987; IPR004499; IPR016061; IPR017449; IPR020056; IPR011035; IPR014729; IPR009068; IPR000738; Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)] Aats-glupro CG5394 Drosophila melanogaster (Fruit fly) TR41534_c0_g1_i4 Q6P7B0 SYWC_RAT 2.00E-10 GO:0005524; GO:0001525; GO:0005737; GO:0045765; GO:0004830; GO:0006436 ATP binding; angiogenesis; cytoplasm; regulation of angiogenesis; tryptophan-tRNA ligase activity; tryptophanyl-tRNA aminoacylation IPR001412; IPR002305; IPR014729; IPR009068; IPR002306; IPR000738; "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" Wars Rattus norvegicus (Rat) TR41534_c0_g1_i5 P28668 SYEP_DROME 0 GO:0005524; GO:0003723; GO:0005737; GO:0004818; GO:0006424; GO:0004827; GO:0006433 ATP binding; RNA binding; cytoplasm; glutamate-tRNA ligase activity; glutamyl-tRNA aminoacylation; proline-tRNA ligase activity; prolyl-tRNA aminoacylation IPR002314; IPR001412; IPR006195; IPR004154; IPR004526; IPR000924; IPR020061; IPR020058; IPR020059; IPR010987; IPR004499; IPR016061; IPR017449; IPR020056; IPR011035; IPR014729; IPR009068; IPR000738; Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)] Aats-glupro CG5394 Drosophila melanogaster (Fruit fly) TR41534_c0_g1_i7 Q6P7B0 SYWC_RAT 4.00E-10 GO:0005524; GO:0001525; GO:0005737; GO:0045765; GO:0004830; GO:0006436 ATP binding; angiogenesis; cytoplasm; regulation of angiogenesis; tryptophan-tRNA ligase activity; tryptophanyl-tRNA aminoacylation IPR001412; IPR002305; IPR014729; IPR009068; IPR002306; IPR000738; "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" Wars Rattus norvegicus (Rat) TR41536_c1_g2_i1 Q9I7F7 PR2_DROME 9.00E-162 GO:0005524; GO:0004715; GO:0004713; GO:0035071 ATP binding; non-membrane spanning protein tyrosine kinase activity; protein tyrosine kinase activity; salivary gland cell autophagic cell death IPR000095; IPR011009; IPR000719; IPR017441; IPR001245; IPR011511; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase PR2 (EC 2.7.10.2) PR2 CG3969 Drosophila melanogaster (Fruit fly) TR41536_c1_g2_i2 Q13470 TNK1_HUMAN 1.00E-67 GO:0005524; GO:0005737; GO:0005829; GO:0016020; GO:0046580; GO:0030308; GO:0004715; GO:0046777; GO:0004871 ATP binding; cytoplasm; cytosol; membrane; negative regulation of Ras protein signal transduction; negative regulation of cell growth; non-membrane spanning protein tyrosine kinase activity; protein autophosphorylation; signal transducer activity IPR011009; IPR000719; IPR017441; IPR001245; IPR001452; IPR008266; IPR020635; Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) TNK1 Homo sapiens (Human) TR41536_c1_g2_i3 Q55GE6 ROCO7_DICDI 7.00E-25 GO:0005524; GO:0005096; GO:0005622; GO:0043547; GO:0004674; GO:0051056 ATP binding; GTPase activator activity; intracellular; positive regulation of GTPase activity; protein serine/threonine kinase activity; regulation of small GTPase mediated signal transduction IPR011009; IPR000719; IPR017441; IPR011047; IPR001936; IPR001245; IPR008271; IPR015943; IPR001680; IPR019775; Probable serine/threonine-protein kinase roco7 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 7) roco7 DDB_G0267472 Dictyostelium discoideum (Slime mold) TR41536_c1_g2_i4 Q9I7F7 PR2_DROME 3.00E-164 GO:0005524; GO:0004715; GO:0004713; GO:0035071 ATP binding; non-membrane spanning protein tyrosine kinase activity; protein tyrosine kinase activity; salivary gland cell autophagic cell death IPR000095; IPR011009; IPR000719; IPR017441; IPR001245; IPR011511; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase PR2 (EC 2.7.10.2) PR2 CG3969 Drosophila melanogaster (Fruit fly) TR41536_c1_g2_i5 Q13470 TNK1_HUMAN 4.00E-69 GO:0005524; GO:0005737; GO:0005829; GO:0016020; GO:0046580; GO:0030308; GO:0004715; GO:0046777; GO:0004871 ATP binding; cytoplasm; cytosol; membrane; negative regulation of Ras protein signal transduction; negative regulation of cell growth; non-membrane spanning protein tyrosine kinase activity; protein autophosphorylation; signal transducer activity IPR011009; IPR000719; IPR017441; IPR001245; IPR001452; IPR008266; IPR020635; Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) TNK1 Homo sapiens (Human) TR41536_c1_g2_i7 B4MR28 PTK7_DROWI 5.00E-24 GO:0005524; GO:0007155; GO:0050839; GO:0016021; GO:0018108; GO:0005886; GO:0004672; GO:0004713; GO:0004872; GO:0031290 ATP binding; cell adhesion; cell adhesion molecule binding; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; protein kinase activity; protein tyrosine kinase activity; receptor activity; retinal ganglion cell axon guidance IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase-like otk (Tyrosine-protein kinase-like 7 homolog) otk GK21983 Drosophila willistoni (Fruit fly) TR41536_c1_g2_i8 Q9I7F7 PR2_DROME 1.00E-171 GO:0005524; GO:0004715; GO:0004713; GO:0035071 ATP binding; non-membrane spanning protein tyrosine kinase activity; protein tyrosine kinase activity; salivary gland cell autophagic cell death IPR000095; IPR011009; IPR000719; IPR017441; IPR001245; IPR011511; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase PR2 (EC 2.7.10.2) PR2 CG3969 Drosophila melanogaster (Fruit fly) TR41537_c1_g1_i1 Q8K385 FRRS1_MOUSE 8.00E-21 GO:0000293; GO:0016021; GO:0046872 ferric-chelate reductase activity; integral to membrane; metal ion binding IPR006593; IPR005018; IPR002861; Ferric-chelate reductase 1 (EC 1.-.-.-) (Stromal cell-derived receptor 2) (SDR-2) FRRS1 Sdfr2 Sdr2 Mus musculus (Mouse) TR41537_c1_g1_i12 A4QP81 FRRS1_DANRE 7.00E-22 GO:0016021; GO:0016491 integral to membrane; oxidoreductase activity IPR006593; IPR005018; IPR002861; Putative ferric-chelate reductase 1 (EC 1.-.-.-) frrs1 zgc:163022 Danio rerio (Zebrafish) (Brachydanio rerio) TR41537_c1_g1_i13 Q8K385 FRRS1_MOUSE 4.00E-20 GO:0000293; GO:0016021; GO:0046872 ferric-chelate reductase activity; integral to membrane; metal ion binding IPR006593; IPR005018; IPR002861; Ferric-chelate reductase 1 (EC 1.-.-.-) (Stromal cell-derived receptor 2) (SDR-2) FRRS1 Sdfr2 Sdr2 Mus musculus (Mouse) TR41537_c1_g1_i14 Q8MSU3 FRRS1_DROME 2.00E-10 GO:0000293; GO:0016021 ferric-chelate reductase activity; integral to membrane IPR006593; IPR005018; IPR002861; Putative ferric-chelate reductase 1 homolog (DmSDR2) (EC 1.-.-.-) CG8399 Drosophila melanogaster (Fruit fly) TR41537_c1_g1_i2 O96382 DFP11_HYPCU 2.00E-13 GO:0042742; GO:0042832; GO:0005576; GO:0045087 defense response to bacterium; defense response to protozoan; extracellular region; innate immune response IPR002861; Putative defense protein Hdd11 (Hyphantria differentially displayed gene 11) Hyphantria cunea (Fall webworm moth) TR41537_c1_g1_i4 A4QP81 FRRS1_DANRE 9.00E-21 GO:0016021; GO:0016491 integral to membrane; oxidoreductase activity IPR006593; IPR005018; IPR002861; Putative ferric-chelate reductase 1 (EC 1.-.-.-) frrs1 zgc:163022 Danio rerio (Zebrafish) (Brachydanio rerio) TR41537_c1_g1_i7 Q0Q028 DFP3_ANTMY 6.00E-15 GO:0042742; GO:0042832; GO:0005576; GO:0045087 defense response to bacterium; defense response to protozoan; extracellular region; innate immune response IPR002861; Putative defense protein 3 (DFP-3) Antheraea mylitta (Tasar silkworm) TR41537_c1_g1_i9 Q86RS3 DFP_MANSE 1.00E-12 GO:0042742; GO:0042832; GO:0005576; GO:0045087 defense response to bacterium; defense response to protozoan; extracellular region; innate immune response IPR002861; Putative defense protein Hdd11-like Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) TR41537_c1_g4_i1 Q9UKA2 FBXL4_HUMAN 5.00E-10 GO:0005737; GO:0005634; GO:0000151; GO:0006511 cytoplasm; nucleus; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process IPR001810; IPR006553; F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) (F-box protein FBL4/FBL5) FBXL4 FBL4 FBL5 Homo sapiens (Human) TR41538_c3_g1_i1 Q9D3P8 PLRKT_MOUSE 2.00E-39 GO:0006935; GO:0006954; GO:0005887; GO:0005739; GO:0010756 chemotaxis; inflammatory response; integral to plasma membrane; mitochondrion; positive regulation of plasminogen activation IPR019319; Plasminogen receptor (KT) (Plg-R(KT)) Plgrkt Mus musculus (Mouse) TR4154_c0_g1_i1 Q99NH0 ANR17_MOUSE 4.00E-12 GO:0003723; GO:0001955; GO:0005737; GO:0007492; GO:0051151; GO:0005634 RNA binding; blood vessel maturation; cytoplasm; endoderm development; negative regulation of smooth muscle cell differentiation; nucleus IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) TR41541_c2_g3_i1 A4IFD7 ZNT7_BOVIN 7.00E-100 GO:0005794; GO:0008324; GO:0016023; GO:0016021; GO:0048471; GO:0032119; GO:0006829 Golgi apparatus; cation transmembrane transporter activity; cytoplasmic membrane-bounded vesicle; integral to membrane; perinuclear region of cytoplasm; sequestering of zinc ion; zinc ion transport IPR002524; IPR027469; Zinc transporter 7 (ZnT-7) (Solute carrier family 30 member 7) SLC30A7 ZNT7 Bos taurus (Bovine) TR41542_c1_g2_i1 O61122 SVKA_DICDI 3.00E-46 GO:0005524; GO:0015629; GO:0007049; GO:0051301; GO:0005813; GO:0032154; GO:0005737; GO:0005829; GO:0006972; GO:0046872; GO:0005634; GO:0051781; GO:0046777; GO:0004674; GO:0032956; GO:0010590; GO:0031156; GO:0005819 ATP binding; actin cytoskeleton; cell cycle; cell division; centrosome; cleavage furrow; cytoplasm; cytosol; hyperosmotic response; metal ion binding; nucleus; positive regulation of cell division; protein autophosphorylation; protein serine/threonine kinase activity; regulation of actin cytoskeleton organization; regulation of cytokinetic cell separation; regulation of sorocarp development; spindle IPR009652; IPR011009; IPR000719; IPR017441; IPR002290; Serine/threonine-protein kinase svkA (EC 2.7.11.1) (Severin kinase A) svkA DDB_G0286359 Dictyostelium discoideum (Slime mold) TR41542_c1_g2_i2 Q64303 PAK2_RAT 2.00E-109 GO:0005524; GO:0016020; GO:0005634; GO:0048471; GO:0004674 ATP binding; membrane; nucleus; perinuclear region of cytoplasm; protein serine/threonine kinase activity IPR000095; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (p21-activated kinase 2) (PAK-2) [Cleaved into: PAK-2p27; PAK-2p34] Pak2 Rattus norvegicus (Rat) TR41542_c1_g3_i4 Q62829 PAK3_RAT 2.00E-92 GO:0005524; GO:0051020; GO:0004708; GO:0007409; GO:0005737; GO:0016358; GO:0046872; GO:0004674; GO:0030833 ATP binding; GTPase binding; MAP kinase kinase activity; axonogenesis; cytoplasm; dendrite development; metal ion binding; protein serine/threonine kinase activity; regulation of actin filament polymerization IPR000095; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (p21-activated kinase 3) (PAK-3) (p65-PAK) Pak3 Rattus norvegicus (Rat) TR41544_c0_g1_i1 P28227 MAOX_ANAPL 0 GO:0051287; GO:0004473; GO:0016619; GO:0006108; GO:0030145; GO:0005739; GO:0051262 NAD binding; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity; malate dehydrogenase (oxaloacetate-decarboxylating) activity; malate metabolic process; manganese ion binding; mitochondrion; protein tetramerization IPR015884; IPR012301; IPR012302; IPR001891; IPR016040; NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) ME1 Anas platyrhynchos (Domestic duck) (Anas boschas) TR41544_c0_g1_i3 P28227 MAOX_ANAPL 0 GO:0051287; GO:0004473; GO:0016619; GO:0006108; GO:0030145; GO:0005739; GO:0051262 NAD binding; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity; malate dehydrogenase (oxaloacetate-decarboxylating) activity; malate metabolic process; manganese ion binding; mitochondrion; protein tetramerization IPR015884; IPR012301; IPR012302; IPR001891; IPR016040; NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) ME1 Anas platyrhynchos (Domestic duck) (Anas boschas) TR41546_c0_g1_i1 B8F7S3 DNAJ_HAEPS 2.00E-11 GO:0005524; GO:0006260; GO:0005737; GO:0006457; GO:0009408; GO:0008270 ATP binding; DNA replication; cytoplasm; protein folding; response to heat; zinc ion binding IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; Chaperone protein DnaJ dnaJ HAPS_1886 Haemophilus parasuis serovar 5 (strain SH0165) TR41546_c0_g1_i2 D3ZD82 DNJ5B_RAT 2.00E-12 GO:0016020 membrane IPR001623; DnaJ homolog subfamily C member 5B (Cysteine string protein beta) (CSP-beta) Dnajc5b Rattus norvegicus (Rat) TR41546_c2_g1_i1 Q3ZCD8 MFF_BOVIN 8.00E-10 GO:0031307; GO:0000266; GO:0008053; GO:0005777; GO:0090141; GO:0090314; GO:0042803 integral to mitochondrial outer membrane; mitochondrial fission; mitochondrial fusion; peroxisome; positive regulation of mitochondrial fission; positive regulation of protein targeting to membrane; protein homodimerization activity IPR008518; Mitochondrial fission factor MFF Bos taurus (Bovine) TR41546_c2_g1_i3 Q5R795 MFF_PONAB 2.00E-09 GO:0016021; GO:0000266; GO:0008053; GO:0005741; GO:0005777; GO:0090141; GO:0090314; GO:0042803 integral to membrane; mitochondrial fission; mitochondrial fusion; mitochondrial outer membrane; peroxisome; positive regulation of mitochondrial fission; positive regulation of protein targeting to membrane; protein homodimerization activity IPR008518; Mitochondrial fission factor MFF Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41546_c2_g1_i5 Q5R795 MFF_PONAB 2.00E-09 GO:0016021; GO:0000266; GO:0008053; GO:0005741; GO:0005777; GO:0090141; GO:0090314; GO:0042803 integral to membrane; mitochondrial fission; mitochondrial fusion; mitochondrial outer membrane; peroxisome; positive regulation of mitochondrial fission; positive regulation of protein targeting to membrane; protein homodimerization activity IPR008518; Mitochondrial fission factor MFF Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41547_c0_g2_i1 P15684 AMPN_RAT 3.00E-179 GO:0004177; GO:0001525; GO:0030154; GO:0006725; GO:0016021; GO:0008237; GO:0035814; GO:0042277; GO:0006508; GO:0031983; GO:0012506; GO:0008270 aminopeptidase activity; angiogenesis; cell differentiation; cellular aromatic compound metabolic process; integral to membrane; metallopeptidase activity; negative regulation of renal sodium excretion; peptide binding; proteolysis; vesicle lumen; vesicle membrane; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (AP-N) (rAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Kidney Zn peptidase) (KZP) (Microsomal aminopeptidase) (CD antigen CD13) Anpep Rattus norvegicus (Rat) TR41547_c0_g2_i3 A6NEC2 PSAL_HUMAN 8.00E-88 GO:0004177; GO:0008237; GO:0006508; GO:0008270 aminopeptidase activity; metallopeptidase activity; proteolysis; zinc ion binding IPR015568; IPR001930; IPR014782; Puromycin-sensitive aminopeptidase-like protein (EC 3.4.11.-) NPEPPSL1 Homo sapiens (Human) TR41547_c0_g2_i6 P79098 AMPN_BOVIN 1.00E-103 GO:0004177; GO:0001525; GO:0030154; GO:0016021; GO:0008237; GO:0006508; GO:0009615; GO:0001618; GO:0008270 aminopeptidase activity; angiogenesis; cell differentiation; integral to membrane; metallopeptidase activity; proteolysis; response to virus; virus receptor activity; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (AP-N) (bAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) ANPEP APN Bos taurus (Bovine) TR41547_c0_g2_i7 P97449 AMPN_MOUSE 3.00E-99 GO:0004177; GO:0001525; GO:0030154; GO:0005793; GO:0009897; GO:0016021; GO:0008237; GO:0006508; GO:0008270 aminopeptidase activity; angiogenesis; cell differentiation; endoplasmic reticulum-Golgi intermediate compartment; external side of plasma membrane; integral to membrane; metallopeptidase activity; proteolysis; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (AP-N) (mAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Membrane protein p161) (Microsomal aminopeptidase) (CD antigen CD13) Anpep Lap-1 Lap1 Mus musculus (Mouse) TR41547_c0_g2_i8 A5DGF3 LKA42_PICGU 1.00E-11 GO:0004177; GO:0005737; GO:0004301; GO:0019370; GO:0004463; GO:0008237; GO:0005634; GO:0043171; GO:0006508; GO:0008270 aminopeptidase activity; cytoplasm; epoxide hydrolase activity; leukotriene biosynthetic process; leukotriene-A4 hydrolase activity; metallopeptidase activity; nucleus; peptide catabolic process; proteolysis; zinc ion binding IPR016024; IPR012777; IPR001930; IPR015211; IPR014782; Lipid metabolism; leukotriene B4 biosynthesis. Leukotriene A-4 hydrolase homolog 2 (LTA-4 hydrolase 2) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) PGUG_02354 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) TR41549_c0_g1_i1 Q6PIJ4 NFRKB_MOUSE 2.00E-94 GO:0003677; GO:0006310; GO:0006281; GO:0031011; GO:0005634; GO:0006355; GO:0006351 "DNA binding; DNA recombination; DNA repair; Ino80 complex; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR024867; IPR025220; Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) Nfrkb Mus musculus (Mouse) TR41550_c0_g1_i1 O94512 OBP1_SCHPO 7.00E-08 GO:0005783; GO:0006696; GO:0008142; GO:0030100 endoplasmic reticulum; ergosterol biosynthetic process; oxysterol binding; regulation of endocytosis IPR000648; Oxysterol-binding protein-like protein 1 obp1 SPBC646.08c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41550_c0_g3_i1 Q9BXB4 OSB11_HUMAN 1.00E-71 GO:0005794; GO:0045444; GO:0031902; GO:0006869; GO:0005543; GO:0010890 Golgi apparatus; fat cell differentiation; late endosome membrane; lipid transport; phospholipid binding; positive regulation of sequestering of triglyceride IPR000648; IPR018494; IPR011993; IPR001849; Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11) OSBPL11 ORP11 OSBP12 Homo sapiens (Human) TR41550_c0_g3_i2 P16258 OSBP1_RABIT 5.00E-12 GO:0000139; GO:0015485; GO:0006869; GO:0005543 Golgi membrane; cholesterol binding; lipid transport; phospholipid binding IPR000648; IPR018494; IPR011993; IPR001849; Oxysterol-binding protein 1 OSBP Oryctolagus cuniculus (Rabbit) TR41550_c0_g3_i3 Q9BXB4 OSB11_HUMAN 7.00E-69 GO:0005794; GO:0045444; GO:0031902; GO:0006869; GO:0005543; GO:0010890 Golgi apparatus; fat cell differentiation; late endosome membrane; lipid transport; phospholipid binding; positive regulation of sequestering of triglyceride IPR000648; IPR018494; IPR011993; IPR001849; Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11) OSBPL11 ORP11 OSBP12 Homo sapiens (Human) TR41550_c0_g3_i4 Q6NTN5 MTMRD_XENLA 4.00E-06 GO:0005737; GO:0005085; GO:0016020; GO:0016791; GO:0005543 cytoplasm; guanyl-nucleotide exchange factor activity; membrane; phosphatase activity; phospholipid binding IPR005112; IPR001194; IPR004182; IPR010569; IPR017906; IPR011993; IPR001849; IPR022096; IPR005113; Myotubularin-related protein 13 (SET-binding factor 2) sbf2 mtmr13 Xenopus laevis (African clawed frog) TR41551_c1_g2_i2 P48542 IRK6_MOUSE 6.00E-126 GO:0015467; GO:0016021 G-protein activated inward rectifier potassium channel activity; integral to membrane IPR014756; IPR016449; IPR003275; IPR013518; "G protein-activated inward rectifier potassium channel 2 (GIRK-2) (Inward rectifier K(+) channel Kir3.2) (Potassium channel, inwardly rectifying subfamily J member 6)" Kcnj6 Girk2 Kcnj7 W Mus musculus (Mouse) TR41551_c1_g2_i3 P48542 IRK6_MOUSE 8.00E-126 GO:0015467; GO:0016021 G-protein activated inward rectifier potassium channel activity; integral to membrane IPR014756; IPR016449; IPR003275; IPR013518; "G protein-activated inward rectifier potassium channel 2 (GIRK-2) (Inward rectifier K(+) channel Kir3.2) (Potassium channel, inwardly rectifying subfamily J member 6)" Kcnj6 Girk2 Kcnj7 W Mus musculus (Mouse) TR41551_c1_g2_i5 P48548 IRK5_RAT 5.00E-125 GO:0015467; GO:0030315; GO:0009897; GO:0016021 G-protein activated inward rectifier potassium channel activity; T-tubule; external side of plasma membrane; integral to membrane IPR014756; IPR016449; IPR003277; IPR013518; "G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)" Kcnj5 Girk4 Rattus norvegicus (Rat) TR41552_c2_g2_i1 A5YM72 CRNS1_HUMAN 3.00E-170 GO:0005524; GO:0016887; GO:0035499; GO:0047730; GO:0046872 ATP binding; ATPase activity; carnosine biosynthetic process; carnosine synthase activity; metal ion binding IPR011761; IPR013816; Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) TR41552_c2_g2_i2 A5YM72 CRNS1_HUMAN 3.00E-131 GO:0005524; GO:0016887; GO:0035499; GO:0047730; GO:0046872 ATP binding; ATPase activity; carnosine biosynthetic process; carnosine synthase activity; metal ion binding IPR011761; IPR013816; Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) TR41553_c9_g1_i1 Q5BL29 S39A9_DANRE 3.00E-56 GO:0016021; GO:0005385 integral to membrane; zinc ion transmembrane transporter activity IPR003689; Zinc transporter ZIP9 (Solute carrier family 39 member 9) (Zrt- and Irt-like protein 9) (ZIP-9) slc39a9 zip9 zgc:101628 Danio rerio (Zebrafish) (Brachydanio rerio) TR41554_c1_g3_i1 Q01H83 SELK_XENTR 9.00E-10 IPR024491; Selenoprotein K (SelK) selk TGas073e13.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41554_c1_g4_i3 Q9BX70 BTBD2_HUMAN 0 GO:0000932 Q7L5N1; P04637 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) TR41555_c1_g1_i1 Q6TV19 DICER_DANRE 2.00E-12 GO:0005524; GO:0008026; GO:0016442; GO:0005737; GO:0035279; GO:0046872; GO:0070883; GO:0031054; GO:0030422; GO:0004525; GO:0030423; GO:0021591 ATP binding; ATP-dependent helicase activity; RISC complex; cytoplasm; mRNA cleavage involved in gene silencing by miRNA; metal ion binding; pre-miRNA binding; pre-miRNA processing; production of siRNA involved in RNA interference; ribonuclease III activity; targeting of mRNA for destruction involved in RNA interference; ventricular system development IPR005034; IPR011545; IPR014720; IPR014001; IPR001650; IPR027417; IPR003100; IPR000999; Endoribonuclease Dicer (EC 3.1.26.-) dicer1 Danio rerio (Zebrafish) (Brachydanio rerio) TR41555_c1_g1_i3 Q6Q899 DDX58_MOUSE 3.00E-95 GO:0005524; GO:0008026; GO:0039529; GO:0015629; GO:0005829; GO:0009597; GO:0003690; GO:0003725; GO:0045087; GO:0002230; GO:0032727; GO:0032728; GO:0042993; GO:0045944; GO:0030334; GO:0043330; GO:0009615; GO:0032587; GO:0003727; GO:0005923; GO:0008270 P22682; Q80ZE3 ATP binding; ATP-dependent helicase activity; RIG-I signaling pathway; actin cytoskeleton; cytosol; detection of virus; double-stranded DNA binding; double-stranded RNA binding; innate immune response; positive regulation of defense response to virus by host; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of cell migration; response to exogenous dsRNA; response to virus; ruffle membrane; single-stranded RNA binding; tight junction; zinc ion binding IPR011029; IPR011545; IPR014001; IPR001650; IPR027417; IPR021673; Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) TR41555_c1_g1_i5 A2RAF3 DCL1_ASPNC 2.00E-16 GO:0005524; GO:0008026; GO:0003723; GO:0006396; GO:0051607; GO:0046872; GO:0050688; GO:0004525 ATP binding; ATP-dependent helicase activity; RNA binding; RNA processing; defense response to virus; metal ion binding; regulation of defense response to virus; ribonuclease III activity IPR005034; IPR011545; IPR014001; IPR001650; IPR027417; IPR000999; Dicer-like protein 1 [Includes: Endoribonuclease dcl1 (EC 3.1.26.-); ATP-dependent helicase dcl1 (EC 3.6.4.-)] dcl1 An18g02950 Aspergillus niger (strain CBS 513.88 / FGSC A1513) TR41556_c1_g3_i11 Q6P2X9 MOT12_XENTR 3.00E-26 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41556_c1_g3_i12 Q5ZJU0 MOT9_CHICK 2.00E-19 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 MCT9 RCJMB04_15m4 Gallus gallus (Chicken) TR41556_c1_g3_i13 Q3MHW6 MOT1_BOVIN 8.00E-19 GO:0016021; GO:0005739; GO:0005886; GO:0015355; GO:0015293 integral to membrane; mitochondrion; plasma membrane; secondary active monocarboxylate transmembrane transporter activity; symporter activity IPR011701; IPR020846; IPR016196; IPR004743; Monocarboxylate transporter 1 (MCT 1) (Solute carrier family 16 member 1) SLC16A1 Bos taurus (Bovine) TR41556_c1_g3_i15 Q6P2X9 MOT12_XENTR 4.00E-26 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41556_c1_g3_i3 Q5ZJU0 MOT9_CHICK 6.00E-19 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 MCT9 RCJMB04_15m4 Gallus gallus (Chicken) TR41556_c1_g3_i6 Q17QR6 MOT13_BOVIN 6.00E-24 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 13 (MCT 13) (Solute carrier family 16 member 13) SLC16A13 MCT13 Bos taurus (Bovine) TR41557_c2_g1_i1 A8WGE3 COR2B_XENTR 1.00E-86 GO:0030036; GO:0005737; GO:0005856; GO:0016020 actin cytoskeleton organization; cytoplasm; cytoskeleton; membrane IPR027339; IPR015505; IPR015048; IPR015049; IPR015943; IPR001680; IPR019775; IPR017986; Coronin-2B coro2b TEgg100f23.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41557_c2_g1_i2 O94244 HAT2_SCHPO 2.00E-06 GO:0006281; GO:0031511; GO:0006995; GO:0031055; GO:0000778; GO:0005829; GO:0016575; GO:0051382; GO:0000070; GO:0070317; GO:0000790; GO:0034501; GO:0031066 Q9P802 DNA repair; Mis6-Sim4 complex; cellular response to nitrogen starvation; chromatin remodeling at centromere; condensed nuclear chromosome kinetochore; cytosol; histone deacetylation; kinetochore assembly; mitotic sister chromatid segregation; negative regulation of G0 to G1 transition; nuclear chromatin; protein localization to kinetochore; regulation of histone deacetylation at centromere IPR020472; IPR022052; IPR015943; IPR001680; IPR019775; IPR017986; Histone acetyltransferase type B subunit 2 (Kinetochore protein mis16) mis16 hat2 SPCC1672.10 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41557_c2_g1_i4 Q92828 COR2A_HUMAN 2.00E-147 GO:0015629; GO:0030036; GO:0051015; GO:0035556; GO:0017053 actin cytoskeleton; actin cytoskeleton organization; actin filament binding; intracellular signal transduction; transcriptional repressor complex IPR027335; IPR015505; IPR015048; IPR015049; IPR015943; IPR001680; IPR019775; IPR017986; Coronin-2A (IR10) (WD repeat-containing protein 2) CORO2A IR10 WDR2 Homo sapiens (Human) TR41557_c2_g1_i6 Q5DFU0 CIAO1_SCHJA 6.00E-10 GO:0016226 iron-sulfur cluster assembly IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog Schistosoma japonicum (Blood fluke) TR41557_c2_g1_i7 Q4X1Y0 PFS2_ASPFU 2.00E-07 GO:0051301; GO:0007059; GO:0005829; GO:0006631; GO:0006397; GO:0007067; GO:0005634; GO:0005777; GO:0005053; GO:0016560 "cell division; chromosome segregation; cytosol; fatty acid metabolic process; mRNA processing; mitosis; nucleus; peroxisome; peroxisome matrix targeting signal-2 binding; protein import into peroxisome matrix, docking" IPR015943; IPR001680; IPR017986; Polyadenylation factor subunit 2 pfs2 AFUA_2G08390 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) TR41558_c3_g2_i1 Q9JJD0 THA11_MOUSE 4.00E-08 GO:0003677; GO:0005825; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "DNA binding; half bridge of spindle pole body; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR006612; THAP domain-containing protein 11 (Ronin) Thap11 MNCb-2032 Mus musculus (Mouse) TR41558_c3_g3_i1 P50947 PHO23_YEAST 3.00E-13 GO:0033698; GO:0016568; GO:0035064; GO:0061188; GO:0061186; GO:0031939; GO:0016479; GO:0061408; GO:0006351; GO:0008270 "Rpd3L complex; chromatin modification; methylated histone residue binding; negative regulation of chromatin silencing at rDNA; negative regulation of chromatin silencing at silent mating-type cassette; negative regulation of chromatin silencing at telomere; negative regulation of transcription from RNA polymerase I promoter; positive regulation of transcription from RNA polymerase II promoter in response to heat stress; transcription, DNA-dependent; zinc ion binding" IPR024610; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Transcriptional regulatory protein PHO23 PHO23 YNL097C N2205 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41558_c4_g1_i10 A4ZNR4 NKD2_DANRE 3.00E-18 GO:0016055; GO:0005509; GO:0005737; GO:0005886 Wnt receptor signaling pathway; calcium ion binding; cytoplasm; plasma membrane IPR011992; IPR018247; IPR002048; Protein naked cuticle homolog 2 (Naked-2) (Protein naked cuticle homolog 2-A) (Naked-2A) nkd2 nkd2a Danio rerio (Zebrafish) (Brachydanio rerio) TR41558_c4_g1_i11 Q99MH6 NKD1_MOUSE 3.00E-19 GO:0016055; GO:0005509; GO:0030154; GO:0005737; GO:0007275; GO:0090090; GO:1901233; GO:0005886; GO:2000096; GO:1901231; GO:0045732; GO:0000159; GO:0007283 P51140 "Wnt receptor signaling pathway; calcium ion binding; cell differentiation; cytoplasm; multicellular organismal development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of convergent extension involved in axis elongation; plasma membrane; positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of non-canonical Wnt receptor signaling pathway via JNK cascade; positive regulation of protein catabolic process; protein phosphatase type 2A complex; spermatogenesis" IPR011992; IPR018247; IPR002048; Protein naked cuticle homolog 1 (Naked-1) (mNkd) (mNkd1) Nkd1 Mus musculus (Mouse) TR41558_c4_g1_i12 Q99MH6 NKD1_MOUSE 2.00E-19 GO:0016055; GO:0005509; GO:0030154; GO:0005737; GO:0007275; GO:0090090; GO:1901233; GO:0005886; GO:2000096; GO:1901231; GO:0045732; GO:0000159; GO:0007283 P51140 "Wnt receptor signaling pathway; calcium ion binding; cell differentiation; cytoplasm; multicellular organismal development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of convergent extension involved in axis elongation; plasma membrane; positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of non-canonical Wnt receptor signaling pathway via JNK cascade; positive regulation of protein catabolic process; protein phosphatase type 2A complex; spermatogenesis" IPR011992; IPR018247; IPR002048; Protein naked cuticle homolog 1 (Naked-1) (mNkd) (mNkd1) Nkd1 Mus musculus (Mouse) TR41558_c4_g1_i2 A4ZNR4 NKD2_DANRE 2.00E-18 GO:0016055; GO:0005509; GO:0005737; GO:0005886 Wnt receptor signaling pathway; calcium ion binding; cytoplasm; plasma membrane IPR011992; IPR018247; IPR002048; Protein naked cuticle homolog 2 (Naked-2) (Protein naked cuticle homolog 2-A) (Naked-2A) nkd2 nkd2a Danio rerio (Zebrafish) (Brachydanio rerio) TR41558_c4_g1_i3 Q99MH6 NKD1_MOUSE 3.00E-19 GO:0016055; GO:0005509; GO:0030154; GO:0005737; GO:0007275; GO:0090090; GO:1901233; GO:0005886; GO:2000096; GO:1901231; GO:0045732; GO:0000159; GO:0007283 P51140 "Wnt receptor signaling pathway; calcium ion binding; cell differentiation; cytoplasm; multicellular organismal development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of convergent extension involved in axis elongation; plasma membrane; positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of non-canonical Wnt receptor signaling pathway via JNK cascade; positive regulation of protein catabolic process; protein phosphatase type 2A complex; spermatogenesis" IPR011992; IPR018247; IPR002048; Protein naked cuticle homolog 1 (Naked-1) (mNkd) (mNkd1) Nkd1 Mus musculus (Mouse) TR41558_c4_g1_i5 Q8VE28 NKD2_MOUSE 4.00E-18 GO:0048210; GO:0016055; GO:0016323; GO:0005509; GO:0016023; GO:0006887; GO:0016328; GO:0090090; GO:0090004; GO:0032436; GO:0010954; GO:0072661 Golgi vesicle fusion to target membrane; Wnt receptor signaling pathway; basolateral plasma membrane; calcium ion binding; cytoplasmic membrane-bounded vesicle; exocytosis; lateral plasma membrane; negative regulation of canonical Wnt receptor signaling pathway; positive regulation of establishment of protein localization to plasma membrane; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein processing; protein targeting to plasma membrane IPR011992; IPR018247; IPR002048; Protein naked cuticle homolog 2 (Naked-2) (mNkd2) Nkd2 Mus musculus (Mouse) TR41558_c4_g1_i6 Q99MH6 NKD1_MOUSE 3.00E-21 GO:0016055; GO:0005509; GO:0030154; GO:0005737; GO:0007275; GO:0090090; GO:1901233; GO:0005886; GO:2000096; GO:1901231; GO:0045732; GO:0000159; GO:0007283 P51140 "Wnt receptor signaling pathway; calcium ion binding; cell differentiation; cytoplasm; multicellular organismal development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of convergent extension involved in axis elongation; plasma membrane; positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of non-canonical Wnt receptor signaling pathway via JNK cascade; positive regulation of protein catabolic process; protein phosphatase type 2A complex; spermatogenesis" IPR011992; IPR018247; IPR002048; Protein naked cuticle homolog 1 (Naked-1) (mNkd) (mNkd1) Nkd1 Mus musculus (Mouse) TR41558_c4_g1_i7 Q2TJA6 NKD1_DANRE 4.00E-18 GO:0070121; GO:0060061; GO:0016055; GO:0005509; GO:0005737; GO:0060971; GO:0003146; GO:0090090; GO:0035414; GO:0001839; GO:0005886 Kupffer's vesicle development; Spemann organizer formation; Wnt receptor signaling pathway; calcium ion binding; cytoplasm; embryonic heart tube left/right pattern formation; heart jogging; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of catenin import into nucleus; neural plate morphogenesis; plasma membrane IPR011992; IPR018247; IPR002048; Protein naked cuticle homolog 1 (Naked-1) nkd1 Danio rerio (Zebrafish) (Brachydanio rerio) TR41558_c4_g1_i9 Q969G9 NKD1_HUMAN 4.00E-16 GO:0016055; GO:0005509; GO:0005737; GO:0001754; GO:0090090; GO:1901233; GO:0005886; GO:2000096; GO:1901231; GO:0045732; GO:0090249; GO:0007525 Q06190-1; Q06190-2 "Wnt receptor signaling pathway; calcium ion binding; cytoplasm; eye photoreceptor cell differentiation; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of convergent extension involved in axis elongation; plasma membrane; positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of non-canonical Wnt receptor signaling pathway via JNK cascade; positive regulation of protein catabolic process; regulation of cell motility involved in somitogenic axis elongation; somatic muscle development" IPR011992; IPR018247; IPR002048; Protein naked cuticle homolog 1 (Naked-1) (hNkd) (hNkd1) NKD1 NKD PP7246 Homo sapiens (Human) TR41560_c6_g1_i1 Q567C3 CA074_DANRE 3.00E-18 IPR027850; UPF0739 protein C1orf74 homolog zgc:112163 Danio rerio (Zebrafish) (Brachydanio rerio) TR41561_c0_g1_i1 A2VD82 TTC38_XENLA 9.00E-151 IPR011990; Tetratricopeptide repeat protein 38 (TPR repeat protein 38) ttc38 Xenopus laevis (African clawed frog) TR41561_c0_g1_i2 A3KPN8 TTC38_DANRE 1.00E-155 IPR011990; Tetratricopeptide repeat protein 38 (TPR repeat protein 38) ttc38 si:ch211-249g22.2 zgc:112407 Danio rerio (Zebrafish) (Brachydanio rerio) TR41562_c1_g2_i1 Q9P2E9 RRBP1_HUMAN 1.00E-07 GO:0030176; GO:0015031; GO:0004872; GO:0005840; GO:0007165; GO:0006412 integral to endoplasmic reticulum membrane; protein transport; receptor activity; ribosome; signal transduction; translation IPR007794; Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) RRBP1 KIAA1398 Homo sapiens (Human) TR41562_c1_g3_i1 Q61595 KTN1_MOUSE 2.00E-19 GO:0005783; GO:0005789; GO:0016021; GO:0019894; GO:0007018 endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; kinesin binding; microtubule-based movement IPR024854; Kinectin Ktn1 Mus musculus (Mouse) TR41562_c1_g3_i4 Q90631 KTN1_CHICK 5.00E-25 GO:0005789; GO:0016021; GO:0007018 endoplasmic reticulum membrane; integral to membrane; microtubule-based movement IPR024854; Kinectin KTN1 Gallus gallus (Chicken) TR41562_c1_g3_i5 Q90631 KTN1_CHICK 5.00E-25 GO:0005789; GO:0016021; GO:0007018 endoplasmic reticulum membrane; integral to membrane; microtubule-based movement IPR024854; Kinectin KTN1 Gallus gallus (Chicken) TR41562_c1_g3_i8 Q90631 KTN1_CHICK 5.00E-25 GO:0005789; GO:0016021; GO:0007018 endoplasmic reticulum membrane; integral to membrane; microtubule-based movement IPR024854; Kinectin KTN1 Gallus gallus (Chicken) TR41563_c1_g1_i1 P28811 MMSB_PSEAE 3.00E-63 GO:0008442; GO:0051287; GO:0004365; GO:0006550; GO:0006552; GO:0006098; GO:0004616; GO:0006574 3-hydroxyisobutyrate dehydrogenase activity; NAD binding; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; isoleucine catabolic process; leucine catabolic process; pentose-phosphate shunt; phosphogluconate dehydrogenase (decarboxylating) activity; valine catabolic process IPR002204; IPR008927; IPR006115; IPR013328; IPR015815; IPR011548; IPR016040; Amino-acid degradation; L-valine degradation. 3-hydroxyisobutyrate dehydrogenase (HIBADH) (EC 1.1.1.31) mmsB PA3569 Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) TR41563_c1_g1_i2 Q2HJD7 3HIDH_BOVIN 3.00E-112 GO:0008442; GO:0051287; GO:0005739; GO:0006098; GO:0004616; GO:0006574 3-hydroxyisobutyrate dehydrogenase activity; NAD binding; mitochondrion; pentose-phosphate shunt; phosphogluconate dehydrogenase (decarboxylating) activity; valine catabolic process IPR008927; IPR006115; IPR013328; IPR015815; IPR011548; IPR016040; Amino-acid degradation; L-valine degradation. "3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31)" HIBADH Bos taurus (Bovine) TR41563_c1_g1_i3 Q9SUC0 3HIDH_ARATH 5.00E-72 GO:0008442; GO:0051287; GO:0005739; GO:0006098; GO:0004616; GO:0006574 3-hydroxyisobutyrate dehydrogenase activity; NAD binding; mitochondrion; pentose-phosphate shunt; phosphogluconate dehydrogenase (decarboxylating) activity; valine catabolic process IPR002204; IPR008927; IPR006115; IPR013328; IPR015815; IPR011548; IPR016040; Amino-acid degradation; L-valine degradation. "Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31)" At4g20930 T13K14.90 Arabidopsis thaliana (Mouse-ear cress) TR41563_c1_g1_i4 P31937 3HIDH_HUMAN 5.00E-112 GO:0008442; GO:0051287; GO:0034641; GO:0005759; GO:0006098; GO:0004616; GO:0006574 3-hydroxyisobutyrate dehydrogenase activity; NAD binding; cellular nitrogen compound metabolic process; mitochondrial matrix; pentose-phosphate shunt; phosphogluconate dehydrogenase (decarboxylating) activity; valine catabolic process IPR002204; IPR008927; IPR006115; IPR013328; IPR015815; IPR011548; IPR016040; Amino-acid degradation; L-valine degradation. "3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31)" HIBADH Homo sapiens (Human) TR41564_c0_g1_i1 Q03001 DYST_HUMAN 8.00E-19 GO:0031673; GO:0030018; GO:0015629; GO:0030424; GO:0007409; GO:0009925; GO:0005604; GO:0005509; GO:0007155; GO:0005938; GO:0007050; GO:0031252; GO:0048870; GO:0016023; GO:0031122; GO:0005829; GO:0005789; GO:0030198; GO:0030056; GO:0031581; GO:0016021; GO:0007229; GO:0005882; GO:0045111; GO:0045104; GO:0030011; GO:0015630; GO:0000226; GO:0035371; GO:0051010; GO:0060053; GO:0005635; GO:0005634; GO:0042803; GO:0031110; GO:0009611; GO:0008090 Q9UKG1; Q9NRI5; Q15691; Q61166; Q96CV9 H zone; Z disc; actin cytoskeleton; axon; axonogenesis; basal plasma membrane; basement membrane; calcium ion binding; cell adhesion; cell cortex; cell cycle arrest; cell leading edge; cell motility; cytoplasmic membrane-bounded vesicle; cytoplasmic microtubule organization; cytosol; endoplasmic reticulum membrane; extracellular matrix organization; hemidesmosome; hemidesmosome assembly; integral to membrane; integrin-mediated signaling pathway; intermediate filament; intermediate filament cytoskeleton; intermediate filament cytoskeleton organization; maintenance of cell polarity; microtubule cytoskeleton; microtubule cytoskeleton organization; microtubule plus end; microtubule plus-end binding; neurofilament cytoskeleton; nuclear envelope; nucleus; protein homodimerization activity; regulation of microtubule polymerization or depolymerization; response to wounding; retrograde axon cargo transport IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; IPR003108; IPR001101; IPR018159; IPR002017; Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) DST BP230 BP240 BPAG1 DMH DT KIAA0728 Homo sapiens (Human) TR41564_c0_g1_i2 Q91ZU6 DYST_MOUSE 7.00E-19 GO:0031673; GO:0030018; GO:0015629; GO:0030424; GO:0007409; GO:0005509; GO:0007155; GO:0005938; GO:0007050; GO:0016023; GO:0031122; GO:0005789; GO:0005925; GO:0030056; GO:0016021; GO:0014704; GO:0005882; GO:0045104; GO:0009898; GO:0046907; GO:0015630; GO:0035371; GO:0051010; GO:0060053; GO:0005635; GO:0005634; GO:0097038; GO:0042803; GO:0031110; GO:0008090; GO:0042383; GO:0001725 P21807 H zone; Z disc; actin cytoskeleton; axon; axonogenesis; calcium ion binding; cell adhesion; cell cortex; cell cycle arrest; cytoplasmic membrane-bounded vesicle; cytoplasmic microtubule organization; endoplasmic reticulum membrane; focal adhesion; hemidesmosome; integral to membrane; intercalated disc; intermediate filament; intermediate filament cytoskeleton organization; internal side of plasma membrane; intracellular transport; microtubule cytoskeleton; microtubule plus end; microtubule plus-end binding; neurofilament cytoskeleton; nuclear envelope; nucleus; perinuclear endoplasmic reticulum; protein homodimerization activity; regulation of microtubule polymerization or depolymerization; retrograde axon cargo transport; sarcolemma; stress fiber IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; IPR003108; IPR001101; IPR018159; IPR002017; Dystonin (Bullous pemphigoid antigen 1) (BPA) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) (Microtubule actin cross-linking factor 2) Dst Bpag1 Macf2 Mus musculus (Mouse) TR41565_c3_g1_i1 Q2LZ58 CHRB_DROPS 1.00E-19 GO:0006915; GO:0005737; GO:0008258; GO:0009968; GO:0032006; GO:0006979 apoptotic process; cytoplasm; head involution; negative regulation of signal transduction; regulation of TOR signaling cascade; response to oxidative stress IPR012918; Protein charybde chrb GA20420 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR41565_c3_g1_i10 Q2LZ58 CHRB_DROPS 2.00E-19 GO:0006915; GO:0005737; GO:0008258; GO:0009968; GO:0032006; GO:0006979 apoptotic process; cytoplasm; head involution; negative regulation of signal transduction; regulation of TOR signaling cascade; response to oxidative stress IPR012918; Protein charybde chrb GA20420 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR41565_c3_g1_i15 Q7T346 DDIT4_DANRE 9.00E-12 GO:0006915; GO:0005737; GO:0009953; GO:0005739; GO:0009968 apoptotic process; cytoplasm; dorsal/ventral pattern formation; mitochondrion; negative regulation of signal transduction IPR012918; DNA damage-inducible transcript 4 protein ddit4 zgc:64114 Danio rerio (Zebrafish) (Brachydanio rerio) TR41565_c3_g1_i17 Q2LZ58 CHRB_DROPS 1.00E-19 GO:0006915; GO:0005737; GO:0008258; GO:0009968; GO:0032006; GO:0006979 apoptotic process; cytoplasm; head involution; negative regulation of signal transduction; regulation of TOR signaling cascade; response to oxidative stress IPR012918; Protein charybde chrb GA20420 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR41565_c3_g1_i6 Q2LZ58 CHRB_DROPS 8.00E-20 GO:0006915; GO:0005737; GO:0008258; GO:0009968; GO:0032006; GO:0006979 apoptotic process; cytoplasm; head involution; negative regulation of signal transduction; regulation of TOR signaling cascade; response to oxidative stress IPR012918; Protein charybde chrb GA20420 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR41565_c3_g1_i7 Q7T346 DDIT4_DANRE 5.00E-12 GO:0006915; GO:0005737; GO:0009953; GO:0005739; GO:0009968 apoptotic process; cytoplasm; dorsal/ventral pattern formation; mitochondrion; negative regulation of signal transduction IPR012918; DNA damage-inducible transcript 4 protein ddit4 zgc:64114 Danio rerio (Zebrafish) (Brachydanio rerio) TR41566_c2_g1_i1 O08863 BIRC3_MOUSE 1.00E-31 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 P39429 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Inhibitor of apoptosis protein 1) (IAP-1) (mIAP-1) (mIAP1) Birc3 Birc2 Iap1 Mus musculus (Mouse) TR41566_c2_g1_i2 Q24307 IAP2_DROME 1.00E-25 GO:0050829; GO:0043066; GO:0043154; GO:0061057; GO:0006964; GO:0033160; GO:0070534; GO:0007423; GO:0008270 "defense response to Gram-negative bacterium; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; peptidoglycan recognition protein signaling pathway; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; positive regulation of protein import into nucleus, translocation; protein K63-linked ubiquitination; sensory organ development; zinc ion binding" IPR001370; IPR001841; IPR013083; Apoptosis 2 inhibitor (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) (dIAP2) Iap2 DIHA ILP CG8293 Drosophila melanogaster (Fruit fly) TR41566_c2_g1_i4 A9ULZ2 BIR7B_XENLA 3.00E-26 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) TR41566_c2_g1_i7 P47732 VF193_IIV6 2.00E-08 GO:0006915; GO:0039650; GO:0008270 apoptotic process; suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process; zinc ion binding IPR001370; IPR001841; IPR013083; Apoptosis inhibitor 193R IIV6-193R Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) TR41566_c2_g1_i8 O08863 BIRC3_MOUSE 1.00E-31 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 P39429 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Inhibitor of apoptosis protein 1) (IAP-1) (mIAP-1) (mIAP1) Birc3 Birc2 Iap1 Mus musculus (Mouse) TR41572_c0_g1_i2 Q6R6I6 RXFP1_RAT 7.00E-25 GO:0004930; GO:0007189; GO:0016021; GO:0046872; GO:0005886 G-protein coupled receptor activity; adenylate cyclase-activating G-protein coupled receptor signaling pathway; integral to membrane; metal ion binding; plasma membrane IPR000276; IPR017452; IPR023415; IPR002172; IPR001611; IPR003591; IPR000372; IPR008112; Relaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1) Rxfp1 Lgr7 Rattus norvegicus (Rat) TR41572_c0_g1_i3 Q9Z2H4 LGR4_RAT 6.00E-142 GO:0007186; GO:0016055; GO:0030282; GO:0046849; GO:0045087; GO:0005887; GO:0050710; GO:0034122; GO:0001649; GO:0090263; GO:0007283; GO:0004888 G-protein coupled receptor signaling pathway; Wnt receptor signaling pathway; bone mineralization; bone remodeling; innate immune response; integral to plasma membrane; negative regulation of cytokine secretion; negative regulation of toll-like receptor signaling pathway; osteoblast differentiation; positive regulation of canonical Wnt receptor signaling pathway; spermatogenesis; transmembrane signaling receptor activity IPR000276; IPR017452; IPR002131; IPR001611; IPR025875; IPR003591; IPR000372; Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48) Lgr4 Gpr48 Rattus norvegicus (Rat) TR41572_c0_g1_i4 A2ARI4 LGR4_MOUSE 4.00E-96 GO:0007186; GO:0030282; GO:0046849; GO:0061290; GO:0072202; GO:0050673; GO:0045087; GO:0005887; GO:0030539; GO:0072224; GO:0072282; GO:0050710; GO:0034122; GO:0045892; GO:0001649; GO:0090190; GO:0090263; GO:0045893; GO:0007283; GO:0004888 "G-protein coupled receptor signaling pathway; bone mineralization; bone remodeling; canonical Wnt receptor signaling pathway involved in metanephric kidney development; cell differentiation involved in metanephros development; epithelial cell proliferation; innate immune response; integral to plasma membrane; male genitalia development; metanephric glomerulus development; metanephric nephron tubule morphogenesis; negative regulation of cytokine secretion; negative regulation of toll-like receptor signaling pathway; negative regulation of transcription, DNA-dependent; osteoblast differentiation; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of transcription, DNA-dependent; spermatogenesis; transmembrane signaling receptor activity" IPR000276; IPR017452; IPR002131; IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48) Lgr4 Gpr48 Mus musculus (Mouse) TR41572_c0_g1_i5 P47799 FSHR_HORSE 3.00E-102 GO:0004963; GO:0042699; GO:0016021; GO:0005886 follicle-stimulating hormone receptor activity; follicle-stimulating hormone signaling pathway; integral to membrane; plasma membrane IPR002272; IPR024635; IPR000276; IPR017452; IPR002131; IPR001611; IPR000372; Follicle-stimulating hormone receptor (FSH-R) (Follitropin receptor) FSHR Equus caballus (Horse) TR41572_c0_g1_i6 A4IIW9 LIGO1_XENTR 2.00E-24 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 lingo1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41572_c0_g1_i7 Q9Z2H4 LGR4_RAT 6.00E-142 GO:0007186; GO:0016055; GO:0030282; GO:0046849; GO:0045087; GO:0005887; GO:0050710; GO:0034122; GO:0001649; GO:0090263; GO:0007283; GO:0004888 G-protein coupled receptor signaling pathway; Wnt receptor signaling pathway; bone mineralization; bone remodeling; innate immune response; integral to plasma membrane; negative regulation of cytokine secretion; negative regulation of toll-like receptor signaling pathway; osteoblast differentiation; positive regulation of canonical Wnt receptor signaling pathway; spermatogenesis; transmembrane signaling receptor activity IPR000276; IPR017452; IPR002131; IPR001611; IPR025875; IPR003591; IPR000372; Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48) Lgr4 Gpr48 Rattus norvegicus (Rat) TR41573_c2_g3_i3 Q16932 STX_APLCA 3.00E-11 GO:0016021; GO:0006886; GO:0006836; GO:0016192 integral to membrane; intracellular protein transport; neurotransmitter transport; vesicle-mediated transport IPR015708; IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin Aplysia californica (California sea hare) TR41573_c2_g3_i4 Q3ZBT5 STX7_BOVIN 2.00E-65 GO:0005484; GO:0000149; GO:0031201; GO:0031901; GO:0016021; GO:0006886; GO:0016079 SNAP receptor activity; SNARE binding; SNARE complex; early endosome membrane; integral to membrane; intracellular protein transport; synaptic vesicle exocytosis IPR006012; IPR006011; IPR010989; IPR000727; Syntaxin-7 STX7 Bos taurus (Bovine) TR41574_c1_g1_i1 Q61P40 TBH1_CAEBR 1.00E-40 GO:0006584; GO:0030054; GO:0005507; GO:0004500; GO:0042136; GO:0008021 catecholamine metabolic process; cell junction; copper ion binding; dopamine beta-monooxygenase activity; neurotransmitter biosynthetic process; synaptic vesicle IPR014784; IPR020611; IPR000323; IPR000945; IPR005018; IPR008977; Tyramine beta-hydroxylase (EC 1.14.17.-) tbh-1 CBG07714 Caenorhabditis briggsae TR41574_c1_g1_i2 Q7Z0T3 TEMPT_APLCA 8.00E-31 GO:0005576 extracellular region Temptin Aplysia californica (California sea hare) TR41574_c1_g1_i3 Q61P40 TBH1_CAEBR 4.00E-40 GO:0006584; GO:0030054; GO:0005507; GO:0004500; GO:0042136; GO:0008021 catecholamine metabolic process; cell junction; copper ion binding; dopamine beta-monooxygenase activity; neurotransmitter biosynthetic process; synaptic vesicle IPR014784; IPR020611; IPR000323; IPR000945; IPR005018; IPR008977; Tyramine beta-hydroxylase (EC 1.14.17.-) tbh-1 CBG07714 Caenorhabditis briggsae TR41574_c1_g1_i4 Q7Z0T3 TEMPT_APLCA 3.00E-34 GO:0005576 extracellular region Temptin Aplysia californica (California sea hare) TR41574_c1_g1_i5 Q9XTA0 DOPO_HORSE 1.00E-33 GO:0031418; GO:0034466; GO:0042584; GO:0005507; GO:0004500; GO:0016021; GO:0042421; GO:0030658 L-ascorbic acid binding; chromaffin granule lumen; chromaffin granule membrane; copper ion binding; dopamine beta-monooxygenase activity; integral to membrane; norepinephrine biosynthetic process; transport vesicle membrane IPR014784; IPR020611; IPR014783; IPR000323; IPR000945; IPR005018; IPR008977; Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1. Dopamine beta-hydroxylase (EC 1.14.17.1) [Cleaved into: Soluble dopamine beta-hydroxylase] DBH Equus caballus (Horse) TR41574_c1_g1_i6 Q64237 DOPO_MOUSE 3.00E-31 GO:0031418; GO:0048149; GO:0001974; GO:0034466; GO:0042584; GO:0005507; GO:0001816; GO:0004500; GO:0042420; GO:0042596; GO:0042593; GO:0042309; GO:0016021; GO:0002443; GO:0050900; GO:0007626; GO:0042711; GO:0007613; GO:0042421; GO:0045907; GO:0042127; GO:2001236; GO:0001975; GO:0048265; GO:0030658; GO:0008542 L-ascorbic acid binding; behavioral response to ethanol; blood vessel remodeling; chromaffin granule lumen; chromaffin granule membrane; copper ion binding; cytokine production; dopamine beta-monooxygenase activity; dopamine catabolic process; fear response; glucose homeostasis; homoiothermy; integral to membrane; leukocyte mediated immunity; leukocyte migration; locomotory behavior; maternal behavior; memory; norepinephrine biosynthetic process; positive regulation of vasoconstriction; regulation of cell proliferation; regulation of extrinsic apoptotic signaling pathway; response to amphetamine; response to pain; transport vesicle membrane; visual learning IPR014784; IPR020611; IPR014783; IPR000323; IPR000945; IPR005018; IPR008977; Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1. Dopamine beta-hydroxylase (EC 1.14.17.1) (Dopamine beta-monooxygenase) [Cleaved into: Soluble dopamine beta-hydroxylase] Dbh Mus musculus (Mouse) TR41575_c0_g1_i1 P55918 MFAP4_BOVIN 3.00E-44 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR014716; IPR014715; IPR002181; Microfibril-associated glycoprotein 4 (36 kDa microfibril-associated glycoprotein) (36 kDa MAP) MFAP4 Bos taurus (Bovine) TR41575_c0_g1_i2 Q9D1H9 MFAP4_MOUSE 5.00E-42 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR014716; IPR014715; IPR002181; Microfibril-associated glycoprotein 4 Mfap4 Mus musculus (Mouse) TR41575_c0_g1_i5 P55918 MFAP4_BOVIN 6.00E-45 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR014716; IPR014715; IPR002181; Microfibril-associated glycoprotein 4 (36 kDa microfibril-associated glycoprotein) (36 kDa MAP) MFAP4 Bos taurus (Bovine) TR41575_c0_g1_i6 O43827 ANGL7_HUMAN 5.00E-43 GO:0005576; GO:0006979 extracellular region; response to oxidative stress IPR014716; IPR014715; IPR002181; Angiopoietin-related protein 7 (Angiopoietin-like factor) (Angiopoietin-like protein 7) (Cornea-derived transcript 6 protein) ANGPTL7 CDT6 UNQ313/PRO356 Homo sapiens (Human) TR41577_c0_g2_i2 Q8K3A9 MEPCE_MOUSE 2.00E-52 GO:0008173; GO:0008757; GO:0035562; GO:0000122; GO:1900087; GO:0040031 RNA methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity; negative regulation of chromatin binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of G1/S transition of mitotic cell cycle; snRNA modification IPR010675; IPR024160; IPR025714; 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) Mepce Bcdin3 Bipl1 D5Wsu46e Mus musculus (Mouse) TR41577_c0_g2_i3 Q5RFI3 BN3D2_PONAB 1.00E-07 GO:0008171; GO:0008173; GO:0005737; GO:0010586; GO:2000632 O-methyltransferase activity; RNA methyltransferase activity; cytoplasm; miRNA metabolic process; negative regulation of pre-miRNA processing IPR010675; IPR024160; Pre-miRNA 5'-monophosphate methyltransferase (EC 2.1.1.-) (BCDIN3 domain-containing protein) BCDIN3D Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41578_c1_g3_i1 Q5R4T3 MLF1_PONAB 6.00E-39 GO:0003677; GO:0007050; GO:0005737; GO:0002318; GO:0005634; GO:0006351 "DNA binding; cell cycle arrest; cytoplasm; myeloid progenitor cell differentiation; nucleus; transcription, DNA-dependent" IPR019376; Myeloid leukemia factor 1 (Myelodysplasia-myeloid leukemia factor 1) MLF1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41578_c1_g3_i2 Q15773 MLF2_HUMAN 2.00E-37 GO:0005737; GO:0006952; GO:0005634 cytoplasm; defense response; nucleus IPR019376; Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2) MLF2 Homo sapiens (Human) TR41578_c1_g3_i3 Q5R4T3 MLF1_PONAB 2.00E-40 GO:0003677; GO:0007050; GO:0005737; GO:0002318; GO:0005634; GO:0006351 "DNA binding; cell cycle arrest; cytoplasm; myeloid progenitor cell differentiation; nucleus; transcription, DNA-dependent" IPR019376; Myeloid leukemia factor 1 (Myelodysplasia-myeloid leukemia factor 1) MLF1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41579_c1_g1_i1 Q6PF69 MVP_XENLA 0 GO:0005737; GO:0005634; GO:0030529 cytoplasm; nucleus; ribonucleoprotein complex IPR021870; IPR002499; Major vault protein (MVP) mvp Xenopus laevis (African clawed frog) TR41579_c1_g1_i3 Q5EAJ7 MVP_STRPU 0 GO:0005737; GO:0005634; GO:0030529 cytoplasm; nucleus; ribonucleoprotein complex IPR000048; IPR021870; IPR002499; Major vault protein (MVP) MVP Strongylocentrotus purpuratus (Purple sea urchin) TR41580_c0_g1_i5 Q28024 GBG12_BOVIN 9.00E-08 GO:0007186; GO:0005834; GO:0004871 G-protein coupled receptor signaling pathway; heterotrimeric G-protein complex; signal transducer activity IPR015898; IPR001770; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Gamma-S1) GNG12 GNGT12 Bos taurus (Bovine) TR41580_c0_g1_i6 O60262 GBG7_HUMAN 8.00E-07 GO:0007186; GO:0001662; GO:0071377; GO:0006112; GO:0005834; GO:0007626; GO:0005886; GO:0007168; GO:0008277; GO:0045761; GO:0004871; GO:0044281; GO:0007268 G-protein coupled receptor signaling pathway; behavioral fear response; cellular response to glucagon stimulus; energy reserve metabolic process; heterotrimeric G-protein complex; locomotory behavior; plasma membrane; receptor guanylyl cyclase signaling pathway; regulation of G-protein coupled receptor protein signaling pathway; regulation of adenylate cyclase activity; signal transducer activity; small molecule metabolic process; synaptic transmission IPR015898; IPR001770; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 GNG7 GNGT7 Homo sapiens (Human) TR41580_c0_g1_i9 Q28024 GBG12_BOVIN 3.00E-07 GO:0007186; GO:0005834; GO:0004871 G-protein coupled receptor signaling pathway; heterotrimeric G-protein complex; signal transducer activity IPR015898; IPR001770; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Gamma-S1) GNG12 GNGT12 Bos taurus (Bovine) TR41581_c0_g1_i1 P79234 C5AR_PONPY 1.00E-07 GO:0004944; GO:0004982; GO:0045177; GO:0016323; GO:0006935; GO:0004878; GO:0006954; GO:0016021; GO:0042789; GO:0070374; GO:0050679 C5a anaphylatoxin receptor activity; N-formyl peptide receptor activity; apical part of cell; basolateral plasma membrane; chemotaxis; complement component C5a receptor activity; inflammatory response; integral to membrane; mRNA transcription from RNA polymerase II promoter; positive regulation of ERK1 and ERK2 cascade; positive regulation of epithelial cell proliferation IPR027809; IPR001274; IPR002234; IPR000826; IPR000276; IPR017452; C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88) (Fragment) C5AR1 C5AR C5R1 Pongo pygmaeus (Bornean orangutan) TR41581_c0_g1_i2 A5A4K9 GHSR_RABIT 1.00E-11 GO:0008154; GO:0008343; GO:0009986; GO:0032869; GO:0046697; GO:0001616; GO:0030252; GO:0016520; GO:0009755; GO:0016021; GO:0045121; GO:0050728; GO:0032691; GO:0045409; GO:0042536; GO:0043005; GO:0005886; GO:0032100; GO:0043568; GO:0040018; GO:0051963; GO:0032094 actin polymerization or depolymerization; adult feeding behavior; cell surface; cellular response to insulin stimulus; decidualization; growth hormone secretagogue receptor activity; growth hormone secretion; growth hormone-releasing hormone receptor activity; hormone-mediated signaling pathway; integral to membrane; membrane raft; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 biosynthetic process; negative regulation of tumor necrosis factor biosynthetic process; neuron projection; plasma membrane; positive regulation of appetite; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; regulation of synapse assembly; response to food IPR003905; IPR000276; IPR017452; Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) GHSR Oryctolagus cuniculus (Rabbit) TR41581_c0_g1_i5 Q9GZQ6 NPFF1_HUMAN 4.00E-10 GO:0016021; GO:0008188; GO:0005886 integral to membrane; neuropeptide receptor activity; plasma membrane IPR000276; IPR017452; IPR005395; IPR005396; Neuropeptide FF receptor 1 (G-protein coupled receptor 147) (RFamide-related peptide receptor OT7T022) NPFFR1 GPR147 NPFF1 Homo sapiens (Human) TR41582_c0_g4_i6 Q6XHB2 ROCO4_DICDI 7.00E-07 GO:0005524; GO:0005525; GO:0005829; GO:0004672; GO:0004674; GO:0031153; GO:0007264; GO:0031150 ATP binding; GTP binding; cytosol; protein kinase activity; protein serine/threonine kinase activity; slug development involved in sorocarp development; small GTPase mediated signal transduction; sorocarp stalk development IPR011009; IPR001611; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR001245; IPR015943; IPR001680; IPR017986; Probable serine/threonine-protein kinase roco4 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 4) roco4 DDB_G0288251 Dictyostelium discoideum (Slime mold) TR41584_c0_g1_i1 Q2VWP9 PRTG_RAT 6.00E-07 GO:0016021; GO:0007275 integral to membrane; multicellular organismal development IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; Protogenin (Protein Shen-Dan) Prtg Rattus norvegicus (Rat) TR41584_c0_g2_i1 Q90610 NEO1_CHICK 5.00E-70 GO:0007155; GO:0016021; GO:0005886 cell adhesion; integral to membrane; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR010560; Neogenin (Fragment) Gallus gallus (Chicken) TR41584_c2_g1_i1 Q9Y2H6 FND3A_HUMAN 9.00E-08 GO:0005794; GO:0000139; GO:0060009; GO:0001669; GO:0016337; GO:0005829; GO:0009566; GO:0016021; GO:0007286; GO:0012506 Golgi apparatus; Golgi membrane; Sertoli cell development; acrosomal vesicle; cell-cell adhesion; cytosol; fertilization; integral to membrane; spermatid development; vesicle membrane IPR003961; IPR013783; Fibronectin type-III domain-containing protein 3A (Human gene expressed in odontoblasts) FNDC3A FNDC3 HUGO KIAA0970 Homo sapiens (Human) TR41584_c2_g2_i1 Q4ZHG4 FNDC1_HUMAN 2.00E-14 GO:0005911; GO:0071456; GO:0005576; GO:0031966; GO:0005886; GO:0010666; GO:0001934; GO:0051223 cell-cell junction; cellular response to hypoxia; extracellular region; mitochondrial membrane; plasma membrane; positive regulation of cardiac muscle cell apoptotic process; positive regulation of protein phosphorylation; regulation of protein transport IPR003961; IPR013783; Fibronectin type III domain-containing protein 1 (Activation-associated cDNA protein) (Expressed in synovial lining protein) FNDC1 FNDC2 KIAA1866 MEL4B3 Homo sapiens (Human) TR41584_c2_g3_i3 Q92859 NEO1_HUMAN 9.00E-22 GO:0007411; GO:0007155; GO:0005887; GO:0055072; GO:0042692; GO:0007520; GO:0051149; GO:0004872; GO:0006355 "axon guidance; cell adhesion; integral to plasma membrane; iron ion homeostasis; muscle cell differentiation; myoblast fusion; positive regulation of muscle cell differentiation; receptor activity; regulation of transcription, DNA-dependent" IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR010560; Neogenin (Immunoglobulin superfamily DCC subclass member 2) NEO1 IGDCC2 NGN Homo sapiens (Human) TR41584_c5_g1_i1 A2A8L5 PTPRF_MOUSE 2.00E-06 GO:0007155; GO:0008201; GO:0016021; GO:0004725 cell adhesion; heparin binding; integral to membrane; protein tyrosine phosphatase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) Ptprf Lar Mus musculus (Mouse) TR41585_c4_g1_i2 P11369 POL2_MOUSE 8.00E-29 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR013544; IPR005135; IPR000477; Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element-1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] Pol Gm17492 Mus musculus (Mouse) TR41586_c2_g1_i1 Q9QYP1 LRP4_RAT 2.00E-112 GO:0016055; GO:0005509; GO:0030154; GO:0009953; GO:0042733; GO:0006897; GO:0001942; GO:0016021; GO:0001822; GO:0090090; GO:0030279; GO:0042475; GO:0005886; GO:0009954; GO:0043113; GO:0001932; GO:0051124 Wnt receptor signaling pathway; calcium ion binding; cell differentiation; dorsal/ventral pattern formation; embryonic digit morphogenesis; endocytosis; hair follicle development; integral to membrane; kidney development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of ossification; odontogenesis of dentin-containing tooth; plasma membrane; proximal/distal pattern formation; receptor clustering; regulation of protein phosphorylation; synaptic growth at neuromuscular junction IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) Lrp4 Megf7 Rattus norvegicus (Rat) TR41586_c2_g1_i5 Q9QYP1 LRP4_RAT 1.00E-113 GO:0016055; GO:0005509; GO:0030154; GO:0009953; GO:0042733; GO:0006897; GO:0001942; GO:0016021; GO:0001822; GO:0090090; GO:0030279; GO:0042475; GO:0005886; GO:0009954; GO:0043113; GO:0001932; GO:0051124 Wnt receptor signaling pathway; calcium ion binding; cell differentiation; dorsal/ventral pattern formation; embryonic digit morphogenesis; endocytosis; hair follicle development; integral to membrane; kidney development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of ossification; odontogenesis of dentin-containing tooth; plasma membrane; proximal/distal pattern formation; receptor clustering; regulation of protein phosphorylation; synaptic growth at neuromuscular junction IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) Lrp4 Megf7 Rattus norvegicus (Rat) TR41588_c3_g1_i2 P27105 STOM_HUMAN 4.00E-59 GO:0005737; GO:0005856; GO:0070062; GO:0005887; GO:0042470; GO:0045121; GO:0051260 cytoplasm; cytoskeleton; extracellular vesicular exosome; integral to plasma membrane; melanosome; membrane raft; protein homooligomerization IPR001107; IPR018080; IPR001972; Erythrocyte band 7 integral membrane protein (Protein 7.2b) (Stomatin) STOM BND7 EPB72 Homo sapiens (Human) TR41588_c5_g3_i1 Q27433 MEC2_CAEEL 4.00E-72 GO:0016021; GO:0007638; GO:0032589 integral to membrane; mechanosensory behavior; neuron projection membrane IPR001107; IPR018080; IPR001972; Mechanosensory protein 2 mec-2 F14D12.4 Caenorhabditis elegans TR41588_c6_g1_i1 Q20657 STO3_CAEEL 6.00E-43 GO:0016021 integral to membrane IPR001107; IPR018080; IPR001972; Stomatin-3 sto-3 F52D10.5 Caenorhabditis elegans TR41590_c0_g1_i5 Q99020 ROAA_MOUSE 2.00E-07 GO:0003677; GO:0003723; GO:0005737; GO:0001837; GO:0000166; GO:0005634; GO:0045893; GO:0030529; GO:0006351 "DNA binding; RNA binding; cytoplasm; epithelial to mesenchymal transition; nucleotide binding; nucleus; positive regulation of transcription, DNA-dependent; ribonucleoprotein complex; transcription, DNA-dependent" IPR012956; IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A) Hnrnpab Cbf-a Cgbfa Hnrpab Mus musculus (Mouse) TR41590_c0_g1_i6 P97379 G3BP2_MOUSE 8.00E-90 GO:0003723; GO:0005622; GO:0051028; GO:0000166; GO:0007264 RNA binding; intracellular; mRNA transport; nucleotide binding; small GTPase mediated signal transduction IPR002075; IPR018222; IPR012677; IPR000504; Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2) G3bp2 Mus musculus (Mouse) TR41591_c2_g1_i1 P41999 NHR10_CAEEL 5.00E-40 GO:0005634; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Nuclear hormone receptor family member nhr-10 nhr-10 B0280.8 Caenorhabditis elegans TR41591_c2_g1_i2 Q91766 HNF4A_XENLA 0 GO:0005634; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR000003; IPR001723; IPR001628; IPR013088; Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) hnf4a hnf4 nr2a1 Xenopus laevis (African clawed frog) TR41591_c2_g1_i3 P70052 NR2E1_XENLA 9.00E-51 GO:0007275; GO:0005634; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "multicellular organismal development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) (Tll) (xTLL) nr2e1 tll tlx Xenopus laevis (African clawed frog) TR41591_c2_g1_i4 P41235 HNF4A_HUMAN 5.00E-176 GO:0001102; GO:0001077; GO:0003705; GO:0060395; GO:0007596; GO:0005737; GO:0031018; GO:0005504; GO:0042593; GO:0030522; GO:0004879; GO:0006629; GO:0030308; GO:0008285; GO:0005654; GO:0006591; GO:0055091; GO:2000189; GO:0042803; GO:0005102; GO:0010470; GO:0060398; GO:0050796; GO:0019216; GO:0009749; GO:0043565; GO:0007548; GO:0023019; GO:0003707; GO:0006367; GO:0044212; GO:0070328; GO:0006805; GO:0008270 Q99967; A8MYZ6 RNA polymerase II activating transcription factor binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; SMAD protein signal transduction; blood coagulation; cytoplasm; endocrine pancreas development; fatty acid binding; glucose homeostasis; intracellular receptor signaling pathway; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; lipid metabolic process; negative regulation of cell growth; negative regulation of cell proliferation; nucleoplasm; ornithine metabolic process; phospholipid homeostasis; positive regulation of cholesterol homeostasis; protein homodimerization activity; receptor binding; regulation of gastrulation; regulation of growth hormone receptor signaling pathway; regulation of insulin secretion; regulation of lipid metabolic process; response to glucose stimulus; sequence-specific DNA binding; sex differentiation; signal transduction involved in regulation of gene expression; steroid hormone receptor activity; transcription initiation from RNA polymerase II promoter; transcription regulatory region DNA binding; triglyceride homeostasis; xenobiotic metabolic process; zinc ion binding IPR003068; IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) HNF4A HNF4 NR2A1 TCF14 Homo sapiens (Human) TR41593_c0_g1_i1 P00191 CP21A_BOVIN 2.00E-29 GO:0005789; GO:0020037; GO:0005506; GO:0004509; GO:0005496; GO:0006694 endoplasmic reticulum membrane; heme binding; iron ion binding; steroid 21-monooxygenase activity; steroid binding; steroid biosynthetic process IPR001128; IPR017972; IPR002401; Steroid 21-hydroxylase (EC 1.14.99.10) (21-OHase) (Cytochrome P-450c21) (Cytochrome P450 21) (Cytochrome P450 XXI) (Cytochrome P450-C21) CYP21 CYP21A1 Bos taurus (Bovine) TR41593_c0_g1_i2 Q9W011 C4D20_DROME 3.00E-20 GO:0005789; GO:0020037; GO:0005506; GO:0004497; GO:0016705 "endoplasmic reticulum membrane; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Probable cytochrome P450 4d20 (EC 1.14.-.-) (CYPIVD20) Cyp4d20 CG16761 Drosophila melanogaster (Fruit fly) TR41593_c0_g1_i4 Q0IIF9 CP2U1_BOVIN 1.00E-43 GO:0070330; GO:0005789; GO:0020037; GO:0016021; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding IPR001128; IPR017972; IPR002401; IPR008069; Cytochrome P450 2U1 (EC 1.14.14.1) CYP2U1 Bos taurus (Bovine) TR41593_c0_g1_i5 O64636 C76C1_ARATH 1.00E-20 GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705 "heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Cytochrome P450 76C1 (EC 1.14.-.-) CYP76C1 At2g45560 F17K2.9 Arabidopsis thaliana (Mouse-ear cress) TR41593_c0_g1_i6 O54750 CP2J6_MOUSE 3.00E-44 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; IPR008071; Cytochrome P450 2J6 (EC 1.14.14.1) (Arachidonic acid epoxygenase) (CYPIIJ6) Cyp2j6 Mus musculus (Mouse) TR41593_c0_g1_i7 Q9XHC6 C93E1_SOYBN 2.00E-19 GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705 "heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Beta-amyrin 24-hydroxylase (EC 1.14.99.43) (Cytochrome P450 93E1) (Sophoradiol 24-hydroxylase) CYP93E1 Glycine max (Soybean) (Glycine hispida) TR41594_c2_g1_i2 A8WHP3 SC5A9_DANRE 1.00E-169 GO:0016021; GO:0006814; GO:0055085; GO:0005215 integral to membrane; sodium ion transport; transmembrane transport; transporter activity IPR001734; IPR018212; IPR019900; Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (Solute carrier family 5 member 9) slc5a9 si:dkey-7o6.5 Danio rerio (Zebrafish) (Brachydanio rerio) TR41595_c0_g1_i1 Q75QN2 INT8_HUMAN 9.00E-09 GO:0032039; GO:0016180 integrator complex; snRNA processing Integrator complex subunit 8 (Int8) (Protein kaonashi-1) INTS8 C8orf52 Homo sapiens (Human) TR41595_c1_g2_i1 Q75QN2 INT8_HUMAN 4.00E-86 GO:0032039; GO:0016180 integrator complex; snRNA processing Integrator complex subunit 8 (Int8) (Protein kaonashi-1) INTS8 C8orf52 Homo sapiens (Human) TR41596_c2_g1_i1 Q9D842 APLF_MOUSE 5.00E-14 GO:0008408; GO:0003906; GO:0005829; GO:0006302; GO:0004520; GO:0046872; GO:0000166; GO:0005634; GO:0000012 3'-5' exonuclease activity; DNA-(apurinic or apyrimidinic site) lyase activity; cytosol; double-strand break repair; endodeoxyribonuclease activity; metal ion binding; nucleotide binding; nucleus; single strand break repair IPR000253; IPR008984; IPR019406; Aprataxin and PNK-like factor (EC 4.2.99.18) (Apurinic-apyrimidinic endonuclease APLF) Aplf Mus musculus (Mouse) TR41596_c3_g2_i1 P17564 PR15A_MOUSE 6.00E-07 GO:0006915; GO:0005783; GO:0030968; GO:0006417 apoptotic process; endoplasmic reticulum; endoplasmic reticulum unfolded protein response; regulation of translation IPR019523; Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) (Myeloid differentiation primary response protein MyD116) Ppp1r15a Gadd34 Myd116 Mus musculus (Mouse) TR41598_c2_g1_i1 Q54KL5 WDR5_DICDI 2.00E-14 GO:0051568; GO:0042393; GO:0035097 histone H3-K4 methylation; histone binding; histone methyltransferase complex IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 5 homolog wdr5 DDB_G0287273 Dictyostelium discoideum (Slime mold) TR41598_c2_g1_i2 P57737 CORO7_HUMAN 3.00E-130 GO:0005794; GO:0000139; GO:0016023; GO:0005829; GO:0016021 Q61471 Golgi apparatus; Golgi membrane; cytoplasmic membrane-bounded vesicle; cytosol; integral to membrane IPR027331; IPR015505; IPR015049; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog) CORO7 Homo sapiens (Human) TR41598_c2_g1_i7 P57737 CORO7_HUMAN 1.00E-128 GO:0005794; GO:0000139; GO:0016023; GO:0005829; GO:0016021 Q61471 Golgi apparatus; Golgi membrane; cytoplasmic membrane-bounded vesicle; cytosol; integral to membrane IPR027331; IPR015505; IPR015049; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog) CORO7 Homo sapiens (Human) TR41602_c0_g1_i2 Q6P0D5 WBP11_DANRE 1.00E-47 GO:0008380; GO:0005737; GO:0006397; GO:0005634; GO:0006364 RNA splicing; cytoplasm; mRNA processing; nucleus; rRNA processing IPR019007; WW domain-binding protein 11 (WBP-11) wbp11 zgc:77390 Danio rerio (Zebrafish) (Brachydanio rerio) TR41603_c0_g1_i1 Q5RBL0 YIPF1_PONAB 3.00E-69 GO:0016021 integral to membrane IPR006977; Protein YIPF1 (YIP1 family member 1) YIPF1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41603_c0_g1_i2 Q5RBL0 YIPF1_PONAB 2.00E-69 GO:0016021 integral to membrane IPR006977; Protein YIPF1 (YIP1 family member 1) YIPF1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41604_c4_g2_i2 Q08DA3 UBP16_BOVIN 3.00E-77 GO:0051301; GO:0004197; GO:0042393; GO:0016578; GO:0007067; GO:0005634; GO:0045893; GO:0051289; GO:0003713; GO:0006351; GO:0043130; GO:0004221; GO:0006511; GO:0004843; GO:0008270 "cell division; cysteine-type endopeptidase activity; histone binding; histone deubiquitination; mitosis; nucleus; positive regulation of transcription, DNA-dependent; protein homotetramerization; transcription coactivator activity; transcription, DNA-dependent; ubiquitin binding; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity; zinc ion binding" IPR018200; IPR001394; IPR013083; IPR001607; Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) USP16 Bos taurus (Bovine) TR41604_c4_g2_i3 Q08DA3 UBP16_BOVIN 3.00E-77 GO:0051301; GO:0004197; GO:0042393; GO:0016578; GO:0007067; GO:0005634; GO:0045893; GO:0051289; GO:0003713; GO:0006351; GO:0043130; GO:0004221; GO:0006511; GO:0004843; GO:0008270 "cell division; cysteine-type endopeptidase activity; histone binding; histone deubiquitination; mitosis; nucleus; positive regulation of transcription, DNA-dependent; protein homotetramerization; transcription coactivator activity; transcription, DNA-dependent; ubiquitin binding; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity; zinc ion binding" IPR018200; IPR001394; IPR013083; IPR001607; Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) USP16 Bos taurus (Bovine) TR41604_c4_g2_i5 Q6PAW2 UBP16_XENLA 2.00E-50 GO:0009952; GO:0051301; GO:0004197; GO:0042393; GO:0016578; GO:0007067; GO:0005634; GO:0045893; GO:0051289; GO:0003713; GO:0006351; GO:0043130; GO:0004221; GO:0006511; GO:0004843; GO:0008270 "anterior/posterior pattern specification; cell division; cysteine-type endopeptidase activity; histone binding; histone deubiquitination; mitosis; nucleus; positive regulation of transcription, DNA-dependent; protein homotetramerization; transcription coactivator activity; transcription, DNA-dependent; ubiquitin binding; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity; zinc ion binding" IPR018200; IPR001394; IPR013083; IPR001607; Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) usp16 Xenopus laevis (African clawed frog) TR41604_c4_g2_i6 Q9P7S5 UBP7_SCHPO 4.00E-19 GO:0005829; GO:0016579; GO:0004221; GO:0006511; GO:0004843; GO:0008270 cytosol; protein deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity; zinc ion binding IPR018200; IPR001394; IPR013083; IPR001607; Probable ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) ubp7 SPAC23G3.08c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41604_c4_g2_i8 Q08DA3 UBP16_BOVIN 3.00E-77 GO:0051301; GO:0004197; GO:0042393; GO:0016578; GO:0007067; GO:0005634; GO:0045893; GO:0051289; GO:0003713; GO:0006351; GO:0043130; GO:0004221; GO:0006511; GO:0004843; GO:0008270 "cell division; cysteine-type endopeptidase activity; histone binding; histone deubiquitination; mitosis; nucleus; positive regulation of transcription, DNA-dependent; protein homotetramerization; transcription coactivator activity; transcription, DNA-dependent; ubiquitin binding; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity; zinc ion binding" IPR018200; IPR001394; IPR013083; IPR001607; Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) USP16 Bos taurus (Bovine) TR41605_c1_g2_i1 Q28BS0 MCM3Z_XENTR 8.00E-27 GO:0005524; GO:0003677; GO:0032508; GO:0003678; GO:0006270; GO:0042555; GO:0007049; GO:0005634 ATP binding; DNA binding; DNA duplex unwinding; DNA helicase activity; DNA replication initiation; MCM complex; cell cycle; nucleus IPR003593; IPR008046; IPR018525; IPR001208; IPR027925; IPR012340; IPR027417; Zygotic DNA replication licensing factor mcm3 (EC 3.6.4.12) (Zygotic minichromosome maintenance protein 3) (zMCM3) zmcm3 TNeu014d13.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41605_c1_g3_i1 P24279 MCM3_YEAST 0 GO:0005524; GO:0006200; GO:0032508; GO:0003678; GO:0006270; GO:0003688; GO:0031261; GO:0006271; GO:0042555; GO:0003682; GO:0030466; GO:0006348; GO:0005737; GO:0000727; GO:0005656; GO:0006267; GO:0031298 P25651; P29496 ATP binding; ATP catabolic process; DNA duplex unwinding; DNA helicase activity; DNA replication initiation; DNA replication origin binding; DNA replication preinitiation complex; DNA strand elongation involved in DNA replication; MCM complex; chromatin binding; chromatin silencing at silent mating-type cassette; chromatin silencing at telomere; cytoplasm; double-strand break repair via break-induced replication; nuclear pre-replicative complex; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; replication fork protection complex IPR003593; IPR008046; IPR018525; IPR001208; IPR027925; IPR012340; IPR027417; DNA replication licensing factor MCM3 (EC 3.6.4.12) (Minichromosome maintenance protein 3) MCM3 YEL032W SYGP-ORF23 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41605_c1_g3_i3 Q7ZXZ0 MCM3Z_XENLA 0 GO:0005524; GO:0003677; GO:0032508; GO:0003678; GO:0006270; GO:0042555; GO:0007049; GO:0005634; GO:0030174 ATP binding; DNA binding; DNA duplex unwinding; DNA helicase activity; DNA replication initiation; MCM complex; cell cycle; nucleus; regulation of DNA-dependent DNA replication initiation IPR003593; IPR008046; IPR018525; IPR001208; IPR027925; IPR012340; IPR027417; Zygotic DNA replication licensing factor mcm3 (EC 3.6.4.12) (Zygotic minichromosome maintenance protein 3) (zMCM3) zmcm3 Xenopus laevis (African clawed frog) TR41606_c0_g2_i2 Q6PCX7 RGMA_MOUSE 3.00E-73 GO:0030509; GO:0031225; GO:0009986; GO:0015026; GO:0001843; GO:0005886; GO:0001934; GO:0030510 BMP signaling pathway; anchored to membrane; cell surface; coreceptor activity; neural tube closure; plasma membrane; positive regulation of protein phosphorylation; regulation of BMP signaling pathway IPR009496; IPR010536; Repulsive guidance molecule A (RGM domain family member A) Rgma Mus musculus (Mouse) TR41606_c0_g5_i1 Q6PCX7 RGMA_MOUSE 9.00E-74 GO:0030509; GO:0031225; GO:0009986; GO:0015026; GO:0001843; GO:0005886; GO:0001934; GO:0030510 BMP signaling pathway; anchored to membrane; cell surface; coreceptor activity; neural tube closure; plasma membrane; positive regulation of protein phosphorylation; regulation of BMP signaling pathway IPR009496; IPR010536; Repulsive guidance molecule A (RGM domain family member A) Rgma Mus musculus (Mouse) TR41607_c3_g1_i10 Q08BH7 UBE2T_DANRE 1.00E-81 GO:0005524; GO:0006281; GO:0003682; GO:0005634; GO:0051865; GO:0006513; GO:0004842 ATP binding; DNA repair; chromatin binding; nucleus; protein autoubiquitination; protein monoubiquitination; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 T (EC 6.3.2.19) (Ubiquitin carrier protein T) (Ubiquitin-protein ligase T) ube2t zgc:153687 Danio rerio (Zebrafish) (Brachydanio rerio) TR41607_c3_g1_i5 Q08BH7 UBE2T_DANRE 2.00E-80 GO:0005524; GO:0006281; GO:0003682; GO:0005634; GO:0051865; GO:0006513; GO:0004842 ATP binding; DNA repair; chromatin binding; nucleus; protein autoubiquitination; protein monoubiquitination; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 T (EC 6.3.2.19) (Ubiquitin carrier protein T) (Ubiquitin-protein ligase T) ube2t zgc:153687 Danio rerio (Zebrafish) (Brachydanio rerio) TR41608_c0_g1_i2 Q8UWJ4 DLLD_DANRE 2.00E-172 GO:0007219; GO:0030165; GO:0005509; GO:0042384; GO:0003140; GO:0048546; GO:0060218; GO:0016021; GO:0046331; GO:0048471; GO:0005886; GO:0021523; GO:0001756 Notch signaling pathway; PDZ domain binding; calcium ion binding; cilium assembly; determination of left/right asymmetry in lateral mesoderm; digestive tract morphogenesis; hematopoietic stem cell differentiation; integral to membrane; lateral inhibition; perinuclear region of cytoplasm; plasma membrane; somatic motor neuron differentiation; somitogenesis IPR001774; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR011651; Delta-like protein D (DeltaD) (After eight protein) dld aei Danio rerio (Zebrafish) (Brachydanio rerio) TR41609_c1_g2_i4 P48555 RALA_DROME 9.00E-105 GO:0005525; GO:0003924; GO:0007464; GO:0007265; GO:0007298; GO:0050829; GO:0007391; GO:0045087; GO:0046329; GO:0045824; GO:0005886; GO:0008593; GO:0022604 GTP binding; GTPase activity; R3/R4 cell fate commitment; Ras protein signal transduction; border follicle cell migration; defense response to Gram-negative bacterium; dorsal closure; innate immune response; negative regulation of JNK cascade; negative regulation of innate immune response; plasma membrane; regulation of Notch signaling pathway; regulation of cell morphogenesis IPR027417; IPR005225; IPR001806; IPR020849; Ras-related protein Ral-a Rala CG2849 Drosophila melanogaster (Fruit fly) TR41609_c1_g2_i5 Q5R4B8 RALB_PONAB 8.00E-14 GO:0005525; GO:0003924; GO:0006915; GO:0000910; GO:0030496; GO:0005886; GO:0001928; GO:0060178; GO:0007264 GTP binding; GTPase activity; apoptotic process; cytokinesis; midbody; plasma membrane; regulation of exocyst assembly; regulation of exocyst localization; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; Ras-related protein Ral-B RALB Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR4161_c0_g1_i1 Q8K0U4 HS12A_MOUSE 3.00E-10 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR41610_c0_g1_i1 Q96NZ1 FOXN4_HUMAN 5.00E-23 GO:0048663; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "neuron fate commitment; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; Forkhead box protein N4 FOXN4 Homo sapiens (Human) TR41610_c1_g2_i1 Q499D0 FOXN3_MOUSE 1.00E-12 GO:0007049; GO:0045892; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "cell cycle; negative regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; Forkhead box protein N3 (Checkpoint suppressor 1) Foxn3 Ches1 Mus musculus (Mouse) TR41610_c1_g2_i2 Q3BJS1 FOXN4_XENLA 3.00E-29 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; Forkhead box protein N4 foxn4 Xenopus laevis (African clawed frog) TR41612_c3_g2_i4 Q8JHV9 BIR7A_XENLA 4.00E-18 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) TR41612_c3_g3_i1 A9JTP3 BIRC7_XENTR 7.00E-28 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP) (Embryonic/Egg IAP) (EIAP/XLX) birc7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41613_c0_g1_i1 P18172 DHGL_DROPS 3.00E-109 GO:0006066; GO:0008812; GO:0005576; GO:0050660 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR41613_c0_g1_i3 Q3JLL7 BETA_BURP1 3.00E-72 GO:0008802; GO:0008812; GO:0050660; GO:0019285 betaine-aldehyde dehydrogenase activity; choline dehydrogenase activity; flavin adenine dinucleotide binding; glycine betaine biosynthetic process from choline IPR011533; IPR012132; IPR000172; IPR007867; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. Oxygen-dependent choline dehydrogenase (CDH) (CHD) (EC 1.1.99.1) (Betaine aldehyde dehydrogenase) (BADH) (EC 1.2.1.8) betA BURPS1710b_A0377 Burkholderia pseudomallei (strain 1710b) TR41615_c3_g2_i1 Q63HN8 RN213_HUMAN 7.00E-07 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR018957; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) TR41615_c4_g1_i15 E9Q555 RN213_MOUSE 3.00E-45 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) Rnf213 Mus musculus (Mouse) TR41615_c4_g1_i9 Q63HN8 RN213_HUMAN 3.00E-82 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR018957; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) TR41617_c0_g1_i1 Q9UBI9 HDC_HUMAN 1.00E-51 GO:0030323 respiratory tube development IPR026066; Headcase protein homolog (hHDC) HECA HDC Homo sapiens (Human) TR41617_c0_g1_i5 Q9UBI9 HDC_HUMAN 2.00E-51 GO:0030323 respiratory tube development IPR026066; Headcase protein homolog (hHDC) HECA HDC Homo sapiens (Human) TR41620_c1_g1_i2 Q6ZWR6 SYNE1_MOUSE 2.00E-34 GO:0005856; GO:0040023; GO:0016021; GO:0005635; GO:0005640; GO:0042803; GO:0030017 cytoskeleton; establishment of nucleus localization; integral to membrane; nuclear envelope; nuclear outer membrane; protein homodimerization activity; sarcomere IPR001589; IPR001715; IPR012315; IPR018159; IPR002017; Nesprin-1 (Enaptin) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) Syne1 Mus musculus (Mouse) TR41621_c1_g3_i1 Q86XE3 EFHA2_HUMAN 4.00E-61 GO:0005509; GO:0016021; GO:0005739 calcium ion binding; integral to membrane; mitochondrion IPR011992; IPR018247; IPR002048; "Calcium uptake protein 3, mitochondrial (EF-hand domain-containing family member A2)" MICU3 EFHA2 Homo sapiens (Human) TR41621_c1_g3_i3 Q95PZ2 MICU1_CAEEL 2.00E-18 GO:0005509; GO:0016021; GO:0031966 calcium ion binding; integral to membrane; mitochondrial membrane IPR011992; IPR018247; IPR002048; "Calcium uptake protein 1 homolog, mitochondrial" Y67H2A.4 Caenorhabditis elegans TR41621_c1_g3_i4 Q8VCX5 MICU1_MOUSE 1.00E-21 GO:0034704; GO:0005509; GO:0070509; GO:0032592; GO:0051560; GO:0006851; GO:0005743 calcium channel complex; calcium ion binding; calcium ion import; integral to mitochondrial membrane; mitochondrial calcium ion homeostasis; mitochondrial calcium ion transport; mitochondrial inner membrane IPR011992; IPR018247; IPR002048; "Calcium uptake protein 1, mitochondrial (Calcium-binding atopy-related autoantigen 1 homolog)" Micu1 Cbara1 Mus musculus (Mouse) TR41621_c1_g4_i11 A2VEI2 MICU1_DROME 2.00E-16 GO:0005509; GO:0016021; GO:0031966 calcium ion binding; integral to membrane; mitochondrial membrane IPR011992; IPR018247; IPR002048; "Calcium uptake protein 1 homolog, mitochondrial" CG4495 Drosophila melanogaster (Fruit fly) TR41621_c1_g4_i2 Q8CD10 EFHA1_MOUSE 8.00E-48 GO:0034704; GO:0005509; GO:0051561; GO:0006851; GO:0005739 calcium channel complex; calcium ion binding; elevation of mitochondrial calcium ion concentration; mitochondrial calcium ion transport; mitochondrion IPR011992; IPR002048; "Calcium uptake protein 2, mitochondrial (EF-hand domain-containing family member A1)" Micu2 Efha1 Mus musculus (Mouse) TR41621_c1_g4_i6 Q8CD10 EFHA1_MOUSE 6.00E-47 GO:0034704; GO:0005509; GO:0051561; GO:0006851; GO:0005739 calcium channel complex; calcium ion binding; elevation of mitochondrial calcium ion concentration; mitochondrial calcium ion transport; mitochondrion IPR011992; IPR002048; "Calcium uptake protein 2, mitochondrial (EF-hand domain-containing family member A1)" Micu2 Efha1 Mus musculus (Mouse) TR41621_c1_g4_i8 Q9CTY5 EFHA2_MOUSE 2.00E-56 GO:0005509; GO:0016021; GO:0005739 calcium ion binding; integral to membrane; mitochondrion IPR011992; IPR018247; IPR002048; "Calcium uptake protein 3, mitochondrial (EF-hand domain-containing family member A2)" Micu3 Efha2 Mus musculus (Mouse) TR41622_c0_g1_i2 Q5ZIT8 TAF2_CHICK 0 GO:0008237; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "metallopeptidase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR016024; IPR014782; Transcription initiation factor TFIID subunit 2 (TBP-associated factor 150 kDa) (Transcription initiation factor TFIID 150 kDa subunit) (TAF(II)150) (TAFII-150) (TAFII150) TAF2 RCJMB04_23j21 Gallus gallus (Chicken) TR41622_c0_g1_i3 P87121 TAF2_SCHPO 1.00E-71 GO:0032153; GO:0000785; GO:0000991; GO:0005829; GO:0008237; GO:0006355; GO:0005669; GO:0006367; GO:0008270 "cell division site; chromatin; core RNA polymerase II binding transcription factor activity; cytosol; metallopeptidase activity; regulation of transcription, DNA-dependent; transcription factor TFIID complex; transcription initiation from RNA polymerase II promoter; zinc ion binding" IPR014782; Transcription initiation factor TFIID subunit 2 (TBP-associated factor 2) taf2 SPAC3A12.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41622_c0_g1_i4 Q32PW3 TAF2_DANRE 1.00E-148 GO:0008237; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "metallopeptidase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR016024; IPR014782; Transcription initiation factor TFIID subunit 2 (TBP-associated factor 150 kDa) (Transcription initiation factor TFIID 150 kDa subunit) (TAF(II)150) (TAFII-150) (TAFII150) taf2 Danio rerio (Zebrafish) (Brachydanio rerio) TR41624_c2_g3_i2 P54731 FAF1_MOUSE 1.00E-07 GO:0034098; GO:0006915; GO:0008219; GO:0007253; GO:0005829; GO:0031072; GO:0005635; GO:0048471; GO:1902043; GO:0031334; GO:0019901; GO:0030155; GO:0042176 Cdc48p-Npl4p-Ufd1p AAA ATPase complex; apoptotic process; cell death; cytoplasmic sequestering of NF-kappaB; cytosol; heat shock protein binding; nuclear envelope; perinuclear region of cytoplasm; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of protein complex assembly; protein kinase binding; regulation of cell adhesion; regulation of protein catabolic process IPR012336; IPR006577; IPR001012; FAS-associated factor 1 Faf1 Mus musculus (Mouse) TR41624_c2_g4_i2 Q5REY7 UBXN7_PONAB 1.00E-80 GO:0034098 Cdc48p-Npl4p-Ufd1p AAA ATPase complex IPR012336; IPR006577; IPR009060; IPR001012; IPR017346; UBX domain-containing protein 7 UBXN7 UBXD7 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41626_c1_g3_i1 Q5R4V4 SARNP_PONAB 4.00E-16 GO:0003677; GO:0003723; GO:0005634; GO:0006355; GO:0006417; GO:0006351 "DNA binding; RNA binding; nucleus; regulation of transcription, DNA-dependent; regulation of translation; transcription, DNA-dependent" IPR003034; SAP domain-containing ribonucleoprotein (Nuclear protein Hcc-1) SARNP HCC1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41627_c0_g3_i1 Q04446 GLGB_HUMAN 0 GO:0003844; GO:0043169; GO:0005829; GO:0006006; GO:0005978; GO:0004553; GO:0044281 "1,4-alpha-glucan branching enzyme activity; cation binding; cytosol; glucose metabolic process; glycogen biosynthetic process; hydrolase activity, hydrolyzing O-glycosyl compounds; small molecule metabolic process" IPR006407; IPR006048; IPR015902; IPR013780; IPR006047; IPR004193; IPR013781; IPR017853; IPR013783; IPR014756; Glycan biosynthesis; glycogen biosynthesis. "1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Brancher enzyme) (Glycogen-branching enzyme)" GBE1 Homo sapiens (Human) TR41627_c0_g3_i2 D2WL32 GLGB3_ARATH 7.00E-146 GO:0003844; GO:0009501; GO:0005975; GO:0043169; GO:0009507; GO:0009570; GO:0009791; GO:0019252 "1,4-alpha-glucan branching enzyme activity; amyloplast; carbohydrate metabolic process; cation binding; chloroplast; chloroplast stroma; post-embryonic development; starch biosynthetic process" IPR006048; IPR015902; IPR013780; IPR006047; IPR013781; IPR017853; IPR013783; Glycan biosynthesis; starch biosynthesis. "1,4-alpha-glucan-branching enzyme 3, chloroplastic/amyloplastic (AtSBE III) (EC 2.4.1.18) (Branching enzyme 1) (AtBE1) (Protein EMBRYO DEFECTIVE 2729) (Starch-branching enzyme 3)" SBE3 BE1 EMB2729 At3g20440 MQC12.20 Arabidopsis thaliana (Mouse-ear cress) TR41631_c2_g1_i2 P49951 CLHC1_BOVIN 4.00E-64 GO:0030132; GO:0030130; GO:0006886; GO:0042470; GO:0030117; GO:0005739; GO:0005198; GO:0016192 Itself clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; intracellular protein transport; melanosome; membrane coat; mitochondrion; structural molecule activity; vesicle-mediated transport IPR016024; IPR000547; IPR016025; IPR015348; IPR001473; IPR022365; IPR016341; IPR011990; Clathrin heavy chain 1 CLTC Bos taurus (Bovine) TR41631_c2_g1_i4 P29742 CLH_DROME 4.00E-63 GO:0030132; GO:0030130; GO:0030125; GO:0005905; GO:0046667; GO:0033227; GO:0030198; GO:0006886; GO:0005811; GO:0035002; GO:0048471; GO:0005886; GO:0045747; GO:0045807; GO:0007594; GO:0040008; GO:0035159; GO:0030141; GO:0033363; GO:0007291; GO:0005198; GO:0008021; GO:0016183; GO:0016079; GO:0005802 P16568 "clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; clathrin vesicle coat; coated pit; compound eye retinal cell programmed cell death; dsRNA transport; extracellular matrix organization; intracellular protein transport; lipid particle; liquid clearance, open tracheal system; perinuclear region of cytoplasm; plasma membrane; positive regulation of Notch signaling pathway; positive regulation of endocytosis; puparial adhesion; regulation of growth; regulation of tube length, open tracheal system; secretory granule; secretory granule organization; sperm individualization; structural molecule activity; synaptic vesicle; synaptic vesicle coating; synaptic vesicle exocytosis; trans-Golgi network" IPR016024; IPR000547; IPR016025; IPR015348; IPR001473; IPR022365; IPR016341; IPR011990; Clathrin heavy chain Chc CG9012 Drosophila melanogaster (Fruit fly) TR41631_c2_g1_i6 Q00610 CLH1_HUMAN 4.00E-65 GO:0019886; GO:0030118; GO:0030132; GO:0030130; GO:0030669; GO:0005829; GO:0070062; GO:0006886; GO:0042470; GO:0005739; GO:0007067; GO:0006892; GO:0031623; GO:0005819; GO:0005198; GO:0032588; GO:0033572 P10242; Q01968; O75674 antigen processing and presentation of exogenous peptide antigen via MHC class II; clathrin coat; clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; clathrin-coated endocytic vesicle membrane; cytosol; extracellular vesicular exosome; intracellular protein transport; melanosome; mitochondrion; mitosis; post-Golgi vesicle-mediated transport; receptor internalization; spindle; structural molecule activity; trans-Golgi network membrane; transferrin transport IPR016024; IPR000547; IPR016025; IPR015348; IPR001473; IPR022365; IPR016341; IPR011990; Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) CLTC CLH17 CLTCL2 KIAA0034 Homo sapiens (Human) TR41631_c2_g1_i7 P25870 CLH_DICDI 4.00E-56 GO:0031152; GO:0048268; GO:0030132; GO:0030130; GO:0071439; GO:0072583; GO:0000915; GO:0006886; GO:0007041; GO:0000281; GO:0006907; GO:0006970; GO:0030435; GO:0005198; GO:0007033 "aggregation involved in sorocarp development; clathrin coat assembly; clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; clathrin complex; clathrin-mediated endocytosis; cytokinesis, actomyosin contractile ring assembly; intracellular protein transport; lysosomal transport; mitotic cytokinesis; pinocytosis; response to osmotic stress; sporulation resulting in formation of a cellular spore; structural molecule activity; vacuole organization" IPR016024; IPR000547; IPR016025; IPR015348; IPR001473; IPR022365; IPR016341; IPR011990; Clathrin heavy chain chcA DDB_G0277221 Dictyostelium discoideum (Slime mold) TR41631_c2_g5_i1 P22137 CLH_YEAST 8.00E-42 GO:0030132; GO:0030130; GO:0030125; GO:0006897; GO:0006886; GO:0005198 P36000; P32790; P38856 clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; clathrin vesicle coat; endocytosis; intracellular protein transport; structural molecule activity IPR016024; IPR000547; IPR016025; IPR015348; IPR001473; IPR016341; IPR011990; Clathrin heavy chain CHC1 YGL206C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41631_c2_g5_i2 Q68FD5 CLH_MOUSE 7.00E-64 GO:0031523; GO:0030132; GO:0030130; GO:0003725; GO:0070062; GO:0006886; GO:0042470; GO:0030117; GO:0005739; GO:0031623; GO:0005819; GO:0090307; GO:0005198; GO:0033572 Myb complex; clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; double-stranded RNA binding; extracellular vesicular exosome; intracellular protein transport; melanosome; membrane coat; mitochondrion; receptor internalization; spindle; spindle assembly involved in mitosis; structural molecule activity; transferrin transport IPR016024; IPR000547; IPR016025; IPR015348; IPR001473; IPR022365; IPR016341; IPR011990; Clathrin heavy chain 1 Cltc Mus musculus (Mouse) TR41631_c2_g5_i6 P49951 CLHC1_BOVIN 5.00E-64 GO:0030132; GO:0030130; GO:0006886; GO:0042470; GO:0030117; GO:0005739; GO:0005198; GO:0016192 Itself clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; intracellular protein transport; melanosome; membrane coat; mitochondrion; structural molecule activity; vesicle-mediated transport IPR016024; IPR000547; IPR016025; IPR015348; IPR001473; IPR022365; IPR016341; IPR011990; Clathrin heavy chain 1 CLTC Bos taurus (Bovine) TR41631_c2_g5_i7 Q00610 CLH1_HUMAN 5.00E-64 GO:0019886; GO:0030118; GO:0030132; GO:0030130; GO:0030669; GO:0005829; GO:0070062; GO:0006886; GO:0042470; GO:0005739; GO:0007067; GO:0006892; GO:0031623; GO:0005819; GO:0005198; GO:0032588; GO:0033572 P10242; Q01968; O75674 antigen processing and presentation of exogenous peptide antigen via MHC class II; clathrin coat; clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; clathrin-coated endocytic vesicle membrane; cytosol; extracellular vesicular exosome; intracellular protein transport; melanosome; mitochondrion; mitosis; post-Golgi vesicle-mediated transport; receptor internalization; spindle; structural molecule activity; trans-Golgi network membrane; transferrin transport IPR016024; IPR000547; IPR016025; IPR015348; IPR001473; IPR022365; IPR016341; IPR011990; Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) CLTC CLH17 CLTCL2 KIAA0034 Homo sapiens (Human) TR41632_c0_g1_i2 Q9NP64 NO40_HUMAN 5.00E-46 GO:0003723; GO:0022625; GO:0005730; GO:0008270 Q6NYC1 RNA binding; cytosolic large ribosomal subunit; nucleolus; zinc ion binding IPR012340; IPR003029; IPR022967; IPR001878; Nucleolar protein of 40 kDa (pNO40) (Pnn-interacting nucleolar protein) (Putative S1 RNA-binding domain protein) (PS1D protein) (Zinc finger CCHC domain-containing protein 17) ZCCHC17 PS1D HSPC243 HSPC251 LDC4 Homo sapiens (Human) TR41633_c0_g1_i1 P27323 HS901_ARATH 0 GO:0005524; GO:0005737; GO:0009816; GO:0006457 Q38931 "ATP binding; cytoplasm; defense response to bacterium, incompatible interaction; protein folding" IPR003594; IPR019805; IPR001404; IPR020575; IPR020568; Heat shock protein 90-1 (AtHSP90.1) (Heat shock protein 81-1) (HSP81-1) (Heat shock protein 83) HSP90-1 HSP81-1 HSP83 At5g52640 F6N7.13 Arabidopsis thaliana (Mouse-ear cress) TR41633_c0_g1_i2 P07900 HS90A_HUMAN 0 GO:0005524; GO:0016887; GO:0002135; GO:0038096; GO:0000086; GO:0005525; GO:0030911; GO:0002134; GO:0016324; GO:0007411; GO:0016323; GO:0031526; GO:0010659; GO:0009986; GO:0051131; GO:0005829; GO:0032564; GO:0071682; GO:0031012; GO:0005576; GO:0045087; GO:0003729; GO:0042470; GO:0001764; GO:0043005; GO:0043025; GO:0046209; GO:0030235; GO:0048471; GO:0005886; GO:0060452; GO:0045793; GO:0010592; GO:0045429; GO:0033160; GO:0043234; GO:0042803; GO:0045040; GO:0042026; GO:0050999; GO:0043627; GO:0009408; GO:0009651; GO:0006986; GO:0003009 Itself; O95433; Q96G23; Q9UHD1; P00533; Q02790; Q14318; P05412; P26882; P53041; Q15185; P61247; Q9UNE7 "ATP binding; ATPase activity; CTP binding; Fc-gamma receptor signaling pathway involved in phagocytosis; G2/M transition of mitotic cell cycle; GTP binding; TPR domain binding; UTP binding; apical plasma membrane; axon guidance; basolateral plasma membrane; brush border membrane; cardiac muscle cell apoptotic process; cell surface; chaperone-mediated protein complex assembly; cytosol; dATP binding; endocytic vesicle lumen; extracellular matrix; extracellular region; innate immune response; mRNA binding; melanosome; neuron migration; neuron projection; neuronal cell body; nitric oxide metabolic process; nitric-oxide synthase regulator activity; perinuclear region of cytoplasm; plasma membrane; positive regulation of cardiac muscle contraction; positive regulation of cell size; positive regulation of lamellipodium assembly; positive regulation of nitric oxide biosynthetic process; positive regulation of protein import into nucleus, translocation; protein complex; protein homodimerization activity; protein import into mitochondrial outer membrane; protein refolding; regulation of nitric-oxide synthase activity; response to estrogen stimulus; response to heat; response to salt stress; response to unfolded protein; skeletal muscle contraction" IPR003594; IPR019805; IPR001404; IPR020575; IPR020568; Heat shock protein HSP 90-alpha (Heat shock 86 kDa) (HSP 86) (HSP86) (Renal carcinoma antigen NY-REN-38) HSP90AA1 HSP90A HSPC1 HSPCA Homo sapiens (Human) TR41633_c0_g1_i3 P30946 HS90A_RABIT 0 GO:0005524; GO:0016887; GO:0051131; GO:0042470; GO:0030235; GO:0045429; GO:0006457; GO:0045040; GO:0006950 ATP binding; ATPase activity; chaperone-mediated protein complex assembly; melanosome; nitric-oxide synthase regulator activity; positive regulation of nitric oxide biosynthetic process; protein folding; protein import into mitochondrial outer membrane; response to stress IPR003594; IPR019805; IPR001404; IPR020575; IPR020568; Heat shock protein HSP 90-alpha HSP90AA1 HSPCA Oryctolagus cuniculus (Rabbit) TR41633_c0_g1_i4 Q14568 HS902_HUMAN 1.00E-114 GO:0005524; GO:0005737; GO:0006457; GO:0006950 ATP binding; cytoplasm; protein folding; response to stress IPR003594; IPR019805; IPR001404; IPR020575; IPR020568; Putative heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) HSP90AA2 HSPCAL3 Homo sapiens (Human) TR41634_c1_g3_i1 O70472 TM131_MOUSE 5.00E-101 GO:0016021 integral to membrane IPR022113; IPR008962; Transmembrane protein 131 (Protein RW1) Tmem131 D1Bwg0491e Kiaa0257 Rw1 Mus musculus (Mouse) TR41634_c1_g7_i1 Q92545 TM131_HUMAN 1.00E-81 GO:0016021 integral to membrane IPR022113; IPR008962; Transmembrane protein 131 (Protein RW1) TMEM131 KIAA0257 RW1 Homo sapiens (Human) TR41635_c2_g1_i1 Q9BVR0 HRC23_HUMAN 7.00E-06 GO:0046872; GO:0004842 metal ion binding; ubiquitin-protein ligase activity IPR010606; Putative HERC2-like protein 3 HERC2P3 Homo sapiens (Human) TR41635_c2_g1_i2 Q8R516 MIB2_MOUSE 4.00E-151 GO:0007219; GO:0005769; GO:0043123; GO:0004871; GO:0000151; GO:0004842; GO:0008270 Notch signaling pathway; early endosome; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity; ubiquitin ligase complex; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Dystrophin-like protein) (Dyslike) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) Mib2 Skd Mus musculus (Mouse) TR41635_c2_g1_i4 Q8R516 MIB2_MOUSE 2.00E-149 GO:0007219; GO:0005769; GO:0043123; GO:0004871; GO:0000151; GO:0004842; GO:0008270 Notch signaling pathway; early endosome; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity; ubiquitin ligase complex; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Dystrophin-like protein) (Dyslike) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) Mib2 Skd Mus musculus (Mouse) TR41635_c2_g1_i5 Q9VFD5 FEM1A_DROME 2.00E-11 GO:0051438; GO:0004842 regulation of ubiquitin-protein ligase activity; ubiquitin-protein ligase activity IPR002110; IPR020683; Protein modification; protein ubiquitination. Protein fem-1 homolog CG6966 CG6966 Drosophila melanogaster (Fruit fly) TR41636_c2_g1_i1 B1WAP7 DVL3_XENTR 7.00E-145 GO:0016055; GO:0008013; GO:0042384; GO:0005737; GO:0035556; GO:0032053; GO:0007275; GO:0004871 Wnt receptor signaling pathway; beta-catenin binding; cilium assembly; cytoplasm; intracellular signal transduction; microtubule basal body organization; multicellular organismal development; signal transducer activity IPR000591; IPR008342; IPR024580; IPR008339; IPR003351; IPR001158; IPR015506; IPR001478; IPR011991; Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) dvl3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41636_c2_g1_i10 B1WAP7 DVL3_XENTR 1.00E-146 GO:0016055; GO:0008013; GO:0042384; GO:0005737; GO:0035556; GO:0032053; GO:0007275; GO:0004871 Wnt receptor signaling pathway; beta-catenin binding; cilium assembly; cytoplasm; intracellular signal transduction; microtubule basal body organization; multicellular organismal development; signal transducer activity IPR000591; IPR008342; IPR024580; IPR008339; IPR003351; IPR001158; IPR015506; IPR001478; IPR011991; Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) dvl3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41636_c2_g1_i3 B1WAP7 DVL3_XENTR 4.00E-147 GO:0016055; GO:0008013; GO:0042384; GO:0005737; GO:0035556; GO:0032053; GO:0007275; GO:0004871 Wnt receptor signaling pathway; beta-catenin binding; cilium assembly; cytoplasm; intracellular signal transduction; microtubule basal body organization; multicellular organismal development; signal transducer activity IPR000591; IPR008342; IPR024580; IPR008339; IPR003351; IPR001158; IPR015506; IPR001478; IPR011991; Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) dvl3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41636_c2_g1_i5 Q05AS8 DVL2_XENTR 4.00E-128 GO:0016055; GO:0032862; GO:0009948; GO:0009986; GO:0035253; GO:0042384; GO:0060027; GO:0016023; GO:0009950; GO:0046875; GO:0048013; GO:0001736; GO:0007163; GO:0001702; GO:0035556; GO:0032053; GO:0001843; GO:0022008; GO:0005634; GO:0005886; GO:0051260; GO:0050821; GO:0004871; GO:0045545 Wnt receptor signaling pathway; activation of Rho GTPase activity; anterior/posterior axis specification; cell surface; ciliary rootlet; cilium assembly; convergent extension involved in gastrulation; cytoplasmic membrane-bounded vesicle; dorsal/ventral axis specification; ephrin receptor binding; ephrin receptor signaling pathway; establishment of planar polarity; establishment or maintenance of cell polarity; gastrulation with mouth forming second; intracellular signal transduction; microtubule basal body organization; neural tube closure; neurogenesis; nucleus; plasma membrane; protein homooligomerization; protein stabilization; signal transducer activity; syndecan binding IPR000591; IPR008341; IPR024580; IPR008339; IPR003351; IPR001158; IPR015506; IPR001478; IPR011991; Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) dvl2 dsh Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41636_c2_g1_i8 B1WAP7 DVL3_XENTR 3.00E-147 GO:0016055; GO:0008013; GO:0042384; GO:0005737; GO:0035556; GO:0032053; GO:0007275; GO:0004871 Wnt receptor signaling pathway; beta-catenin binding; cilium assembly; cytoplasm; intracellular signal transduction; microtubule basal body organization; multicellular organismal development; signal transducer activity IPR000591; IPR008342; IPR024580; IPR008339; IPR003351; IPR001158; IPR015506; IPR001478; IPR011991; Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) dvl3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41636_c2_g1_i9 Q05AS8 DVL2_XENTR 1.00E-127 GO:0016055; GO:0032862; GO:0009948; GO:0009986; GO:0035253; GO:0042384; GO:0060027; GO:0016023; GO:0009950; GO:0046875; GO:0048013; GO:0001736; GO:0007163; GO:0001702; GO:0035556; GO:0032053; GO:0001843; GO:0022008; GO:0005634; GO:0005886; GO:0051260; GO:0050821; GO:0004871; GO:0045545 Wnt receptor signaling pathway; activation of Rho GTPase activity; anterior/posterior axis specification; cell surface; ciliary rootlet; cilium assembly; convergent extension involved in gastrulation; cytoplasmic membrane-bounded vesicle; dorsal/ventral axis specification; ephrin receptor binding; ephrin receptor signaling pathway; establishment of planar polarity; establishment or maintenance of cell polarity; gastrulation with mouth forming second; intracellular signal transduction; microtubule basal body organization; neural tube closure; neurogenesis; nucleus; plasma membrane; protein homooligomerization; protein stabilization; signal transducer activity; syndecan binding IPR000591; IPR008341; IPR024580; IPR008339; IPR003351; IPR001158; IPR015506; IPR001478; IPR011991; Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) dvl2 dsh Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41637_c0_g2_i1 Q9CYP7 SESN3_MOUSE 1.00E-140 GO:0007050; GO:0005634 cell cycle arrest; nucleus IPR006730; Sestrin-3 Sesn3 Sest3 Mus musculus (Mouse) TR41637_c0_g2_i3 Q9CYP7 SESN3_MOUSE 1.00E-139 GO:0007050; GO:0005634 cell cycle arrest; nucleus IPR006730; Sestrin-3 Sesn3 Sest3 Mus musculus (Mouse) TR41638_c0_g1_i1 Q8IZH2 XRN1_HUMAN 2.00E-69 GO:0008409; GO:0003677; GO:0005794; GO:0003723; GO:0000932; GO:0005829; GO:0043928; GO:0010467; GO:0071044; GO:0045111; GO:0071028; GO:0090305; GO:0005886; GO:0016075 5'-3' exonuclease activity; DNA binding; Golgi apparatus; RNA binding; cytoplasmic mRNA processing body; cytosol; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; gene expression; histone mRNA catabolic process; intermediate filament cytoskeleton; nuclear mRNA surveillance; nucleic acid phosphodiester bond hydrolysis; plasma membrane; rRNA catabolic process IPR027073; IPR016494; IPR004859; 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog) XRN1 SEP1 Homo sapiens (Human) TR41640_c5_g1_i1 Q9W539 HR4_DROME 3.00E-39 GO:0071456; GO:0040007; GO:0030518; GO:0004879; GO:0005634; GO:0048638; GO:0043565; GO:0003707; GO:0008270 cellular response to hypoxia; growth; intracellular steroid hormone receptor signaling pathway; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleus; regulation of developmental growth; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Hormone receptor 4 (dHR4) (Nuclear receptor subfamily 6 group A member 2) Hr4 NR6A2 CG43934 Drosophila melanogaster (Fruit fly) TR41640_c7_g2_i1 Q3ZC71 DPM3_BOVIN 4.00E-17 GO:0006506; GO:0033185; GO:0004582; GO:0030176; GO:0031647 GPI anchor biosynthetic process; dolichol-phosphate-mannose synthase complex; dolichyl-phosphate beta-D-mannosyltransferase activity; integral to endoplasmic reticulum membrane; regulation of protein stability IPR013174; Dolichol-phosphate mannosyltransferase subunit 3 (DPM synthase complex subunit 3) (Dolichol-phosphate mannose synthase subunit 3) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 3) (Mannose-P-dolichol synthase subunit 3) (MPD synthase subunit 3) DPM3 Bos taurus (Bovine) TR41641_c0_g1_i4 Q09221 CPNA2_CAEEL 4.00E-88 IPR010734; IPR002035; Copine family protein 2 cpna-2 B0228.4 Caenorhabditis elegans TR41641_c0_g1_i5 Q09221 CPNA2_CAEEL 1.00E-55 IPR010734; IPR002035; Copine family protein 2 cpna-2 B0228.4 Caenorhabditis elegans TR41642_c1_g2_i1 P53934 YNJ2_YEAST 5.00E-21 GO:0008757 Itself; P38822; P45976; P47138; P19262; P34758; Q03935; Q03703 S-adenosylmethionine-dependent methyltransferase activity IPR012901; UPF0586 protein YNL092W YNL092W N2227 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41642_c1_g4_i1 Q5BJZ6 CI041_RAT 2.00E-69 IPR012901; UPF0586 protein C9orf41 homolog Rattus norvegicus (Rat) TR41642_c1_g4_i3 Q5BJZ6 CI041_RAT 3.00E-81 IPR012901; UPF0586 protein C9orf41 homolog Rattus norvegicus (Rat) TR41642_c1_g4_i7 P53934 YNJ2_YEAST 3.00E-24 GO:0008757 Itself; P38822; P45976; P47138; P19262; P34758; Q03935; Q03703 S-adenosylmethionine-dependent methyltransferase activity IPR012901; UPF0586 protein YNL092W YNL092W N2227 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41643_c2_g4_i3 Q9C0R2 RTF22_SCHPO 6.00E-14 TR41644_c1_g1_i2 Q9UTH0 NU132_SCHPO 8.00E-15 GO:0051301; GO:0007094; GO:0031965; GO:0031081; GO:0031080; GO:0016973 Q10331 cell division; mitotic spindle assembly checkpoint; nuclear membrane; nuclear pore distribution; nuclear pore outer ring; poly(A)+ mRNA export from nucleus IPR007187; IPR014908; IPR015943; Nucleoporin nup132 (Nuclear pore protein nup132) nup132 nup133b SPAC1805.04 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41644_c1_g1_i3 Q8R0G9 NU133_MOUSE 0 GO:0000940; GO:0006406; GO:0006999; GO:0031080; GO:0005487; GO:0048339; GO:0015031 condensed chromosome outer kinetochore; mRNA export from nucleus; nuclear pore organization; nuclear pore outer ring; nucleocytoplasmic transporter activity; paraxial mesoderm development; protein transport IPR007187; IPR014908; IPR015943; Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) Nup133 Mus musculus (Mouse) TR41645_c6_g2_i2 P79795 NRP1_CHICK 1.00E-10 GO:0001525; GO:0007411; GO:0007155; GO:0035767; GO:0008201; GO:0016021; GO:0046872; GO:0009887; GO:0017154; GO:0048010; GO:0005021 angiogenesis; axon guidance; cell adhesion; endothelial cell chemotaxis; heparin binding; integral to membrane; metal ion binding; organ morphogenesis; semaphorin receptor activity; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor-activated receptor activity IPR000421; IPR008985; IPR000859; IPR008979; IPR000998; IPR014648; IPR022579; IPR027146; Neuropilin-1 (A5 protein) NRP1 NRP Gallus gallus (Chicken) TR41645_c6_g2_i3 P98072 ENTK_BOVIN 3.00E-16 GO:0016021; GO:0006508; GO:0005044; GO:0004252 integral to membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity IPR008985; IPR000859; IPR023415; IPR002172; IPR000998; IPR011163; IPR001254; IPR018114; IPR001314; IPR000082; IPR001190; IPR017448; IPR009003; Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain] TMPRSS15 ENTK PRSS7 Bos taurus (Bovine) TR41645_c6_g2_i4 P98072 ENTK_BOVIN 2.00E-17 GO:0016021; GO:0006508; GO:0005044; GO:0004252 integral to membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity IPR008985; IPR000859; IPR023415; IPR002172; IPR000998; IPR011163; IPR001254; IPR018114; IPR001314; IPR000082; IPR001190; IPR017448; IPR009003; Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain] TMPRSS15 ENTK PRSS7 Bos taurus (Bovine) TR41646_c2_g1_i1 Q8CGN4 BCOR_MOUSE 3.00E-45 GO:0031519; GO:0007507; GO:0035518; GO:0030502; GO:0000415; GO:0051572; GO:0070171; GO:0000122; GO:0005634; GO:0042476; GO:0060021; GO:0065001; GO:0003714; GO:0044212; GO:0006351; GO:0004842 "PcG protein complex; heart development; histone H2A monoubiquitination; negative regulation of bone mineralization; negative regulation of histone H3-K36 methylation; negative regulation of histone H3-K4 methylation; negative regulation of tooth mineralization; negative regulation of transcription from RNA polymerase II promoter; nucleus; odontogenesis; palate development; specification of axis polarity; transcription corepressor activity; transcription regulatory region DNA binding; transcription, DNA-dependent; ubiquitin-protein ligase activity" IPR002110; IPR020683; BCL-6 corepressor (BCoR) Bcor Kiaa1575 Mus musculus (Mouse) TR41650_c0_g1_i1 Q5RJZ1 RTEL1_RAT 5.00E-20 GO:0051539; GO:0005524; GO:0004003; GO:0003677; GO:0006281; GO:0046872; GO:0005634; GO:0010569; GO:0000723 "4 iron, 4 sulfur cluster binding; ATP binding; ATP-dependent DNA helicase activity; DNA binding; DNA repair; metal ion binding; nucleus; regulation of double-strand break repair via homologous recombination; telomere maintenance" IPR006555; IPR010614; IPR013020; IPR014013; IPR006554; IPR006935; IPR027417; Regulator of telomere elongation helicase 1 (EC 3.6.4.12) Rtel1 Rattus norvegicus (Rat) TR41650_c0_g1_i2 O08811 ERCC2_MOUSE 0 GO:0051539; GO:0043139; GO:0005524; GO:0004003; GO:0003677; GO:0071817; GO:0008353; GO:0009650; GO:0007568; GO:0006915; GO:0030282; GO:0000075; GO:0008283; GO:0032289; GO:0007059; GO:0019907; GO:0005737; GO:0040016; GO:0043249; GO:0030198; GO:0035315; GO:0048820; GO:0060218; GO:0005675; GO:0001701; GO:0046872; GO:0035264; GO:0033683; GO:0043388; GO:0045944; GO:0009791; GO:0006979; GO:0021510; GO:0006366; GO:0006283 "4 iron, 4 sulfur cluster binding; 5'-3' DNA helicase activity; ATP binding; ATP-dependent DNA helicase activity; DNA binding; MMXD complex; RNA polymerase II carboxy-terminal domain kinase activity; UV protection; aging; apoptotic process; bone mineralization; cell cycle checkpoint; cell proliferation; central nervous system myelin formation; chromosome segregation; cyclin-dependent protein kinase activating kinase holoenzyme complex; cytoplasm; embryonic cleavage; erythrocyte maturation; extracellular matrix organization; hair cell differentiation; hair follicle maturation; hematopoietic stem cell differentiation; holo TFIIH complex; in utero embryonic development; metal ion binding; multicellular organism growth; nucleotide-excision repair, DNA incision; positive regulation of DNA binding; positive regulation of transcription from RNA polymerase II promoter; post-embryonic development; response to oxidative stress; spinal cord development; transcription from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair" IPR006555; IPR010614; IPR002464; IPR013020; IPR010643; IPR014013; IPR006554; IPR027417; IPR001945; TFIIH basal transcription factor complex helicase XPD subunit (EC 3.6.4.12) (CXPD) (DNA excision repair protein ERCC-2) (DNA repair protein complementing XP-D cells) (Xeroderma pigmentosum group D-complementing protein) Ercc2 Xpd Mus musculus (Mouse) TR41650_c0_g1_i4 O08811 ERCC2_MOUSE 3.00E-139 GO:0051539; GO:0043139; GO:0005524; GO:0004003; GO:0003677; GO:0071817; GO:0008353; GO:0009650; GO:0007568; GO:0006915; GO:0030282; GO:0000075; GO:0008283; GO:0032289; GO:0007059; GO:0019907; GO:0005737; GO:0040016; GO:0043249; GO:0030198; GO:0035315; GO:0048820; GO:0060218; GO:0005675; GO:0001701; GO:0046872; GO:0035264; GO:0033683; GO:0043388; GO:0045944; GO:0009791; GO:0006979; GO:0021510; GO:0006366; GO:0006283 "4 iron, 4 sulfur cluster binding; 5'-3' DNA helicase activity; ATP binding; ATP-dependent DNA helicase activity; DNA binding; MMXD complex; RNA polymerase II carboxy-terminal domain kinase activity; UV protection; aging; apoptotic process; bone mineralization; cell cycle checkpoint; cell proliferation; central nervous system myelin formation; chromosome segregation; cyclin-dependent protein kinase activating kinase holoenzyme complex; cytoplasm; embryonic cleavage; erythrocyte maturation; extracellular matrix organization; hair cell differentiation; hair follicle maturation; hematopoietic stem cell differentiation; holo TFIIH complex; in utero embryonic development; metal ion binding; multicellular organism growth; nucleotide-excision repair, DNA incision; positive regulation of DNA binding; positive regulation of transcription from RNA polymerase II promoter; post-embryonic development; response to oxidative stress; spinal cord development; transcription from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair" IPR006555; IPR010614; IPR002464; IPR013020; IPR010643; IPR014013; IPR006554; IPR027417; IPR001945; TFIIH basal transcription factor complex helicase XPD subunit (EC 3.6.4.12) (CXPD) (DNA excision repair protein ERCC-2) (DNA repair protein complementing XP-D cells) (Xeroderma pigmentosum group D-complementing protein) Ercc2 Xpd Mus musculus (Mouse) TR41650_c0_g2_i3 Q4WWE9 CHL1_ASPFU 8.00E-16 GO:0005524; GO:0004003; GO:0003677; GO:0007049; GO:0005634 ATP binding; ATP-dependent DNA helicase activity; DNA binding; cell cycle; nucleus IPR006555; IPR027076; IPR010614; IPR002464; IPR013020; IPR014013; IPR006554; ATP-dependent RNA helicase chl1 (EC 3.6.4.13) (Chromosome loss protein 1) chl1 AFUA_3G05590 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) TR41651_c1_g1_i1 Q8IWZ8 SUGP1_HUMAN 5.00E-43 GO:0003723; GO:0000398; GO:0005654; GO:0005681 O43143; P98175; Q96I25; P26368 "RNA binding; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex" IPR000467; IPR000061; SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4) SUGP1 SF4 Homo sapiens (Human) TR41651_c1_g1_i2 Q94C11 SUGP1_ARATH 1.00E-11 GO:0003723; GO:0008380; GO:0006397; GO:0005634 RNA binding; RNA splicing; mRNA processing; nucleus IPR000467; IPR000061; SURP and G-patch domain-containing protein 1-like protein (Splicing factor 4-like protein) (SF4-like protein) At3g52120 F4F15.230 Arabidopsis thaliana (Mouse-ear cress) TR41651_c1_g2_i2 Q68FU8 SUGP1_RAT 8.00E-21 GO:0003723; GO:0008380; GO:0006397; GO:0005681 RNA binding; RNA splicing; mRNA processing; spliceosomal complex IPR000467; IPR000061; SURP and G-patch domain-containing protein 1 (Splicing factor 4) Sugp1 Sf4 Rattus norvegicus (Rat) TR41651_c1_g2_i4 Q8CH09 SUGP2_MOUSE 1.00E-08 GO:0003723; GO:0008380; GO:0006397; GO:0005634 RNA binding; RNA splicing; mRNA processing; nucleus IPR000467; IPR000061; "SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14)" Sugp2 Sfrs14 Srsf14 Mus musculus (Mouse) TR41652_c0_g2_i1 Q52KR2 LRIG2_MOUSE 3.00E-27 GO:0005737; GO:0016021; GO:0005886 cytoplasm; integral to membrane; plasma membrane IPR000483; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR001611; IPR003591; Leucine-rich repeats and immunoglobulin-like domains protein 2 (LIG-2) Lrig2 Kiaa0806 Mus musculus (Mouse) TR41652_c0_g2_i2 Q6R5N8 TLR13_MOUSE 3.00E-15 GO:0002755; GO:0005768; GO:0010008; GO:0006954; GO:0045087; GO:0016021; GO:0042803; GO:0019843; GO:0043408; GO:0002237; GO:0009615; GO:0034178; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; endosome; endosome membrane; inflammatory response; innate immune response; integral to membrane; protein homodimerization activity; rRNA binding; regulation of MAPK cascade; response to molecule of bacterial origin; response to virus; toll-like receptor 13 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR003591; IPR000157; IPR027196; Toll-like receptor 13 Tlr13 Mus musculus (Mouse) TR41655_c0_g1_i1 Q5RJH6 SMG7_MOUSE 2.00E-108 GO:0005737; GO:0000184; GO:0005634; GO:0051721 "cytoplasm; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus; protein phosphatase 2A binding" IPR018834; IPR019458; IPR011990; Protein SMG7 (EST1-like protein C) (SMG-7 homolog) Smg7 Est1c Kiaa0250 Mus musculus (Mouse) TR41656_c2_g1_i1 P72745 Y1101_SYNY3 1.00E-06 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein Slr1101 (USP Slr1101) slr1101 Synechocystis sp. (strain PCC 6803 / Kazusa) TR41656_c2_g1_i3 O07552 NHAX_BACSU 7.00E-08 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Stress response protein NhaX nhaX yheK BSU09690 Bacillus subtilis (strain 168) TR41657_c2_g10_i1 Q5BIM1 TRI45_BOVIN 1.00E-07 GO:0005737; GO:0005634; GO:0008270 cytoplasm; nucleus; zinc ion binding IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) TR41659_c0_g1_i1 P30776 RAD21_SCHPO 2.00E-34 GO:0008608; GO:0051301; GO:0000775; GO:0000794; GO:0000724; GO:0030892; GO:0007064 "attachment of spindle microtubules to kinetochore; cell division; chromosome, centromeric region; condensed nuclear chromosome; double-strand break repair via homologous recombination; mitotic cohesin complex; mitotic sister chromatid cohesion" IPR023093; IPR006909; IPR006910; Cohesin subunit rad21 (Double-strand-break repair protein rad21) (SCC1 homolog) rad21 SPCC338.17c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41659_c0_g1_i2 D2HSB3 RD21L_AILME 3.00E-68 GO:0007059; GO:0007126; GO:0030893; GO:0007128; GO:0000228; GO:0005634 chromosome segregation; meiosis; meiotic cohesin complex; meiotic prophase I; nuclear chromosome; nucleus IPR023093; IPR006909; IPR006910; Double-strand-break repair protein rad21-like protein 1 RAD21L1 RAD21L PANDA_014969 Ailuropoda melanoleuca (Giant panda) TR41659_c0_g1_i4 O60216 RAD21_HUMAN 9.00E-85 GO:0006915; GO:0051301; GO:0007059; GO:0000775; GO:0008278; GO:0005829; GO:0006302; GO:0007067; GO:0000278; GO:0034991; GO:0005654; GO:0071168; GO:0007131; GO:0006357 Q29RF7; Q9NTI5; Q9UQE7; Q9NP77; Q7Z5K2 "apoptotic process; cell division; chromosome segregation; chromosome, centromeric region; cohesin complex; cytosol; double-strand break repair; mitosis; mitotic cell cycle; nuclear meiotic cohesin complex; nucleoplasm; protein localization to chromatin; reciprocal meiotic recombination; regulation of transcription from RNA polymerase II promoter" IPR023093; IPR006909; IPR006910; Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) RAD21 HR21 KIAA0078 NXP1 Homo sapiens (Human) TR41660_c0_g2_i1 Q9Y572 RIPK3_HUMAN 6.00E-36 GO:0005524; GO:0007249; GO:0004704; GO:0035666; GO:0032147; GO:1990000; GO:0097190; GO:0005829; GO:0045087; GO:0005739; GO:0070266; GO:0005886; GO:0051092; GO:0060545; GO:0010922; GO:0032481; GO:0046777; GO:0032403; GO:0051291; GO:0051260; GO:0004674; GO:0034138; GO:0034142; GO:0003713 Itself; Q13490; Q13489; Q8NB16; Q13546; Q8IXJ6; Q9H171 ATP binding; I-kappaB kinase/NF-kappaB cascade; NF-kappaB-inducing kinase activity; TRIF-dependent toll-like receptor signaling pathway; activation of protein kinase activity; amyloid fibril formation; apoptotic signaling pathway; cytosol; innate immune response; mitochondrion; necroptosis; plasma membrane; positive regulation of NF-kappaB transcription factor activity; positive regulation of necroptosis; positive regulation of phosphatase activity; positive regulation of type I interferon production; protein autophosphorylation; protein complex binding; protein heterooligomerization; protein homooligomerization; protein serine/threonine kinase activity; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; transcription coactivator activity IPR011009; IPR000719; IPR017441; IPR025735; IPR008271; Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) RIPK3 RIP3 Homo sapiens (Human) TR41660_c0_g2_i2 Q8NFD2 ANKK1_HUMAN 3.00E-37 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR001245; IPR008271; Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) TR41660_c0_g2_i5 Q95UN8 M3KSL_DROME 4.00E-23 GO:0005524; GO:0004706; GO:0007257; GO:0071361; GO:0046843; GO:0007394; GO:0046529; GO:0048804; GO:0048803; GO:0046330; GO:0046777; GO:0042803; GO:0009408 "ATP binding; JUN kinase kinase kinase activity; activation of JUN kinase activity; cellular response to ethanol; dorsal appendage formation; dorsal closure, elongation of leading edge cells; imaginal disc fusion, thorax closure; imaginal disc-derived female genitalia morphogenesis; imaginal disc-derived male genitalia morphogenesis; positive regulation of JNK cascade; protein autophosphorylation; protein homodimerization activity; response to heat" IPR011009; IPR000719; IPR001245; IPR008271; IPR001452; Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase) (Protein slipper) (dMLK) slpr Mlk2 CG2272 Drosophila melanogaster (Fruit fly) TR41661_c0_g1_i1 Q7YR26 TOP1_CHLAE 0 GO:0005524; GO:0003677; GO:0003917; GO:0003918; GO:0006265; GO:0003682; GO:0005694; GO:0005730; GO:0005654 ATP binding; DNA binding; DNA topoisomerase type I activity; DNA topoisomerase type II (ATP-hydrolyzing) activity; DNA topological change; chromatin binding; chromosome; nucleolus; nucleoplasm IPR011010; IPR013034; IPR001631; IPR018521; IPR025834; IPR014711; IPR014727; IPR013500; IPR008336; IPR013030; IPR013499; DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) TOP1 Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) TR41661_c0_g1_i4 Q7YR26 TOP1_CHLAE 0 GO:0005524; GO:0003677; GO:0003917; GO:0003918; GO:0006265; GO:0003682; GO:0005694; GO:0005730; GO:0005654 ATP binding; DNA binding; DNA topoisomerase type I activity; DNA topoisomerase type II (ATP-hydrolyzing) activity; DNA topological change; chromatin binding; chromosome; nucleolus; nucleoplasm IPR011010; IPR013034; IPR001631; IPR018521; IPR025834; IPR014711; IPR014727; IPR013500; IPR008336; IPR013030; IPR013499; DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) TOP1 Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) TR41661_c0_g1_i6 Q7YR26 TOP1_CHLAE 0 GO:0005524; GO:0003677; GO:0003917; GO:0003918; GO:0006265; GO:0003682; GO:0005694; GO:0005730; GO:0005654 ATP binding; DNA binding; DNA topoisomerase type I activity; DNA topoisomerase type II (ATP-hydrolyzing) activity; DNA topological change; chromatin binding; chromosome; nucleolus; nucleoplasm IPR011010; IPR013034; IPR001631; IPR018521; IPR025834; IPR014711; IPR014727; IPR013500; IPR008336; IPR013030; IPR013499; DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) TOP1 Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) TR41662_c2_g1_i1 Q9JIX5 CHD8_RAT 7.00E-55 GO:0005524; GO:0043044; GO:0003677; GO:0003678; GO:0008094; GO:0071339; GO:0008013; GO:0060070; GO:0001701; GO:0035064; GO:0030178; GO:0043066; GO:0045892; GO:0002039; GO:0045944; GO:0045945; GO:0006351 "ATP binding; ATP-dependent chromatin remodeling; DNA binding; DNA helicase activity; DNA-dependent ATPase activity; MLL1 complex; beta-catenin binding; canonical Wnt receptor signaling pathway; in utero embryonic development; methylated histone residue binding; negative regulation of Wnt receptor signaling pathway; negative regulation of apoptotic process; negative regulation of transcription, DNA-dependent; p53 binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; transcription, DNA-dependent" IPR006576; IPR023780; IPR000953; IPR016197; IPR014001; IPR001650; IPR027417; IPR000330; Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Axis duplication inhibitor) (Duplin) Chd8 Rattus norvegicus (Rat) TR41662_c3_g4_i1 B5DE69 CHD8_XENTR 5.00E-175 GO:0005524; GO:0003677; GO:0071339; GO:0016055; GO:0016568; GO:0004386; GO:0006355; GO:0006351 "ATP binding; DNA binding; MLL1 complex; Wnt receptor signaling pathway; chromatin modification; helicase activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006576; IPR023780; IPR000953; IPR016197; IPR014001; IPR001650; IPR027417; IPR000330; Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) chd8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41662_c3_g4_i3 A2AJK6 CHD7_MOUSE 0 GO:0005524; GO:0003677; GO:0030217; GO:0007512; GO:0007628; GO:0048844; GO:0008015; GO:0043010; GO:0003682; GO:0016568; GO:0050890; GO:0035116; GO:0060429; GO:0060324; GO:0030540; GO:0003007; GO:0004386; GO:0001701; GO:0043584; GO:0005634; GO:0042048; GO:0021772; GO:0021553; GO:0060021; GO:0040018; GO:0006364; GO:0060123; GO:0050767; GO:0006355; GO:0060041; GO:0048752; GO:0007605; GO:0001501; GO:0006351 Q60I23 "ATP binding; DNA binding; T cell differentiation; adult heart development; adult walking behavior; artery morphogenesis; blood circulation; camera-type eye development; chromatin binding; chromatin modification; cognition; embryonic hindlimb morphogenesis; epithelium development; face development; female genitalia development; heart morphogenesis; helicase activity; in utero embryonic development; nose development; nucleus; olfactory behavior; olfactory bulb development; olfactory nerve development; palate development; positive regulation of multicellular organism growth; rRNA processing; regulation of growth hormone secretion; regulation of neurogenesis; regulation of transcription, DNA-dependent; retina development in camera-type eye; semicircular canal morphogenesis; sensory perception of sound; skeletal system development; transcription, DNA-dependent" IPR006576; IPR023780; IPR000953; IPR016197; IPR014001; IPR001650; IPR027417; IPR001005; IPR000330; Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.12) (ATP-dependent helicase CHD7) Chd7 Mus musculus (Mouse) TR41663_c3_g1_i1 P08548 LIN1_NYCCO 6.00E-19 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR41663_c3_g1_i2 P08548 LIN1_NYCCO 6.00E-19 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR41663_c3_g2_i4 P16423 POLR_DROME 6.00E-10 GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0046872; GO:0090305; GO:0006508 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR000477; IPR007087; IPR015880; Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM (Retrovirus-related Pol polyprotein from type II retrotransposable element R2DM) [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR41664_c0_g1_i1 P12007 IVD_RAT 5.00E-11 GO:0033539; GO:0050660; GO:0008470; GO:0006552; GO:0005759; GO:0031966; GO:0051260 fatty acid beta-oxidation using acyl-CoA dehydrogenase; flavin adenine dinucleotide binding; isovaleryl-CoA dehydrogenase activity; leucine catabolic process; mitochondrial matrix; mitochondrial membrane; protein homooligomerization IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3. "Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) (EC 1.3.8.4)" Ivd Rattus norvegicus (Rat) TR41664_c0_g1_i2 Q5RBD5 IVD_PONAB 3.00E-13 GO:0003995; GO:0050660; GO:0006552; GO:0005759 acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; leucine catabolic process; mitochondrial matrix IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3. "Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) (EC 1.3.8.4)" IVD Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41664_c0_g1_i5 Q3SZI8 IVD_BOVIN 2.00E-11 GO:0003995; GO:0050660; GO:0006552; GO:0005759 acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; leucine catabolic process; mitochondrial matrix IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3. "Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) (EC 1.3.8.4)" IVD Bos taurus (Bovine) TR41664_c0_g1_i6 Q54R47 GCDH_DICDI 1.00E-08 GO:0003995; GO:0050660; GO:0005759; GO:0005739; GO:0006568 acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; mitochondrial matrix; mitochondrion; tryptophan metabolic process IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Amino-acid metabolism; lysine degradation. Amino-acid metabolism; tryptophan metabolism. "Glutaryl-CoA dehydrogenase, mitochondrial (GCD) (EC 1.3.8.6)" gcdh DDB_G0283411 Dictyostelium discoideum (Slime mold) TR41664_c0_g3_i1 Q8K370 ACD10_MOUSE 4.00E-91 GO:0003995; GO:0050660; GO:0016787; GO:0005739; GO:0016772 "acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; hydrolase activity; mitochondrion; transferase activity, transferring phosphorus-containing groups" IPR006091; IPR009075; IPR013786; IPR009100; IPR002575; IPR023214; IPR006439; IPR011945; IPR011009; IPR023198; Acyl-CoA dehydrogenase family member 10 (ACAD-10) (EC 1.3.99.-) Acad10 Mus musculus (Mouse) TR41664_c0_g3_i4 Q9FS87 IVD2_SOLTU 1.00E-07 GO:1902198; GO:0050660; GO:0008470; GO:1902196; GO:0006552; GO:0005739 3-methylbut-2-enoyl-CoA(4-) metabolic process; flavin adenine dinucleotide binding; isovaleryl-CoA dehydrogenase activity; isovaleryl-CoA(4-) catabolic process; leucine catabolic process; mitochondrion IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3. "Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) (EC 1.3.8.4) (Isovaleryl-CoA dehydrogenase 2) (St-IVD2)" IVD IVD2 PGSC0003DMG400008113 Solanum tuberosum (Potato) TR41664_c0_g3_i5 Q8K370 ACD10_MOUSE 4.00E-90 GO:0003995; GO:0050660; GO:0016787; GO:0005739; GO:0016772 "acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; hydrolase activity; mitochondrion; transferase activity, transferring phosphorus-containing groups" IPR006091; IPR009075; IPR013786; IPR009100; IPR002575; IPR023214; IPR006439; IPR011945; IPR011009; IPR023198; Acyl-CoA dehydrogenase family member 10 (ACAD-10) (EC 1.3.99.-) Acad10 Mus musculus (Mouse) TR41665_c1_g1_i1 Q14315 FLNC_HUMAN 2.00E-63 GO:0030018; GO:0034329; GO:0043034; GO:0005856; GO:0005829; GO:0048747; GO:0042383; GO:0016528 P00519; P46108; O75923; P62993; Q9UBF9 Z disc; cell junction assembly; costamere; cytoskeleton; cytosol; muscle fiber development; sarcolemma; sarcoplasm IPR001589; IPR001715; IPR003961; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) FLNC ABPL FLN2 Homo sapiens (Human) TR41665_c1_g1_i2 P13466 GELA_DICDI 3.00E-12 GO:0030036; GO:0051015; GO:0030864; GO:0006972; GO:0001891; GO:0042331; GO:0042803; GO:0030587; GO:0043052 actin cytoskeleton organization; actin filament binding; cortical actin cytoskeleton; hyperosmotic response; phagocytic cup; phototaxis; protein homodimerization activity; sorocarp development; thermotaxis IPR001589; IPR001715; IPR001298; IPR017868; IPR013783; IPR014756; Gelation factor (Actin-binding protein 120) (ABP-120) abpC DDB_G0269100 Dictyostelium discoideum (Slime mold) TR41665_c1_g1_i3 P21333 FLNA_HUMAN 0 GO:0034988; GO:0031523; GO:0048365; GO:0017160; GO:0051764; GO:0015629; GO:0031532; GO:0051015; GO:0007195; GO:0005938; GO:0034329; GO:0042384; GO:0051220; GO:0005829; GO:0045022; GO:0001837; GO:0045184; GO:0070062; GO:0001948; GO:0042177; GO:0043433; GO:0005634; GO:0005886; GO:0030168; GO:0002576; GO:0043123; GO:0042993; GO:0042803; GO:0034394; GO:0050821; GO:0043113; GO:0004871; GO:0090307; GO:0005802 Q9WMX2; Q8N264; O95067; P46108; O75369; Q12948; P62993; P05556; P07228; P26010; O14786; P35372; Q86SQ0 Fc-gamma receptor I complex binding; Myb complex; Rac GTPase binding; Ral GTPase binding; actin crosslink formation; actin cytoskeleton; actin cytoskeleton reorganization; actin filament binding; adenylate cyclase-inhibiting dopamine receptor signaling pathway; cell cortex; cell junction assembly; cilium assembly; cytoplasmic sequestering of protein; cytosol; early endosome to late endosome transport; epithelial to mesenchymal transition; establishment of protein localization; extracellular vesicular exosome; glycoprotein binding; negative regulation of protein catabolic process; negative regulation of sequence-specific DNA binding transcription factor activity; nucleus; plasma membrane; platelet activation; platelet degranulation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor import into nucleus; protein homodimerization activity; protein localization to cell surface; protein stabilization; receptor clustering; signal transducer activity; spindle assembly involved in mitosis; trans-Golgi network IPR001589; IPR001715; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) FLNA FLN FLN1 Homo sapiens (Human) TR41665_c1_g1_i7 P21333 FLNA_HUMAN 0 GO:0034988; GO:0031523; GO:0048365; GO:0017160; GO:0051764; GO:0015629; GO:0031532; GO:0051015; GO:0007195; GO:0005938; GO:0034329; GO:0042384; GO:0051220; GO:0005829; GO:0045022; GO:0001837; GO:0045184; GO:0070062; GO:0001948; GO:0042177; GO:0043433; GO:0005634; GO:0005886; GO:0030168; GO:0002576; GO:0043123; GO:0042993; GO:0042803; GO:0034394; GO:0050821; GO:0043113; GO:0004871; GO:0090307; GO:0005802 Q9WMX2; Q8N264; O95067; P46108; O75369; Q12948; P62993; P05556; P07228; P26010; O14786; P35372; Q86SQ0 Fc-gamma receptor I complex binding; Myb complex; Rac GTPase binding; Ral GTPase binding; actin crosslink formation; actin cytoskeleton; actin cytoskeleton reorganization; actin filament binding; adenylate cyclase-inhibiting dopamine receptor signaling pathway; cell cortex; cell junction assembly; cilium assembly; cytoplasmic sequestering of protein; cytosol; early endosome to late endosome transport; epithelial to mesenchymal transition; establishment of protein localization; extracellular vesicular exosome; glycoprotein binding; negative regulation of protein catabolic process; negative regulation of sequence-specific DNA binding transcription factor activity; nucleus; plasma membrane; platelet activation; platelet degranulation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor import into nucleus; protein homodimerization activity; protein localization to cell surface; protein stabilization; receptor clustering; signal transducer activity; spindle assembly involved in mitosis; trans-Golgi network IPR001589; IPR001715; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) FLNA FLN FLN1 Homo sapiens (Human) TR41667_c0_g1_i1 P28271 ACOC_MOUSE 0 GO:0051539; GO:0005794; GO:0003994; GO:0006879; GO:0006101; GO:0005829; GO:0005783; GO:0050892; GO:0030350; GO:0046872; GO:0005739; GO:0009791; GO:0006417; GO:0010040; GO:0006099 "4 iron, 4 sulfur cluster binding; Golgi apparatus; aconitate hydratase activity; cellular iron ion homeostasis; citrate metabolic process; cytosol; endoplasmic reticulum; intestinal absorption; iron-responsive element binding; metal ion binding; mitochondrion; post-embryonic development; regulation of translation; response to iron(II) ion; tricarboxylic acid cycle" IPR015931; IPR015937; IPR001030; IPR015928; IPR006249; IPR015934; IPR015932; IPR018136; IPR000573; Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) Aco1 Ireb1 Irebp Mus musculus (Mouse) TR41667_c0_g1_i2 Q47WG2 LEUC_COLP3 3.00E-17 GO:0003861; GO:0051539; GO:0009098; GO:0046872 "3-isopropylmalate dehydratase activity; 4 iron, 4 sulfur cluster binding; leucine biosynthetic process; metal ion binding" IPR004430; IPR015931; IPR015937; IPR001030; IPR015932; IPR018136; Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4. 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase) leuC CPS_4210 Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) TR41667_c0_g1_i3 P19414 ACON_YEAST 8.00E-31 GO:0051539; GO:0003994; GO:0005829; GO:0003690; GO:0046872; GO:0000002; GO:0005758; GO:0042645; GO:0003697; GO:0006099 "4 iron, 4 sulfur cluster binding; aconitate hydratase activity; cytosol; double-stranded DNA binding; metal ion binding; mitochondrial genome maintenance; mitochondrial intermembrane space; mitochondrial nucleoid; single-stranded DNA binding; tricarboxylic acid cycle" IPR015931; IPR015937; IPR001030; IPR015928; IPR015932; IPR018136; IPR006248; IPR000573; Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. "Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)" ACO1 GLU1 YLR304C L8003.22 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41668_c0_g2_i1 Q91YE6 IPO9_MOUSE 0 GO:0008536; GO:0005737; GO:0042393; GO:0005634; GO:0050821; GO:0008565; GO:0006610; GO:0042254 Ran GTPase binding; cytoplasm; histone binding; nucleus; protein stabilization; protein transporter activity; ribosomal protein import into nucleus; ribosome biogenesis IPR011989; IPR016024; IPR001494; Importin-9 (Imp9) (Importin-9a) (Imp9a) (Importin-9b) (Imp9b) (Ran-binding protein 9) (RanBP9) Ipo9 Imp9 Ranbp9 Mus musculus (Mouse) TR41668_c0_g2_i2 Q91YE6 IPO9_MOUSE 0 GO:0008536; GO:0005737; GO:0042393; GO:0005634; GO:0050821; GO:0008565; GO:0006610; GO:0042254 Ran GTPase binding; cytoplasm; histone binding; nucleus; protein stabilization; protein transporter activity; ribosomal protein import into nucleus; ribosome biogenesis IPR011989; IPR016024; IPR001494; Importin-9 (Imp9) (Importin-9a) (Imp9a) (Importin-9b) (Imp9b) (Ran-binding protein 9) (RanBP9) Ipo9 Imp9 Ranbp9 Mus musculus (Mouse) TR41669_c0_g2_i1 Q8WUU4 ZN296_HUMAN 1.00E-24 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0007283; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; spermatogenesis; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 296 (ZFP296) (Zinc finger protein 342) ZNF296 ZNF342 Homo sapiens (Human) TR41669_c0_g2_i2 Q9C0K0 BC11B_HUMAN 8.00E-42 GO:0000978; GO:0001077; GO:0033077; GO:0033153; GO:0046632; GO:0003382; GO:0003334; GO:0046872; GO:0043066; GO:0008285; GO:0005634; GO:0042475; GO:0071678; GO:0043368; GO:0045944; GO:0031077; GO:0010837; GO:0019216; GO:0045664; GO:0021773; GO:0048538 Q13547; Q92769; O43463 RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; T cell differentiation in thymus; T cell receptor V(D)J recombination; alpha-beta T cell differentiation; epithelial cell morphogenesis; keratinocyte development; metal ion binding; negative regulation of apoptotic process; negative regulation of cell proliferation; nucleus; odontogenesis of dentin-containing tooth; olfactory bulb axon guidance; positive T cell selection; positive regulation of transcription from RNA polymerase II promoter; post-embryonic camera-type eye development; regulation of keratinocyte proliferation; regulation of lipid metabolic process; regulation of neuron differentiation; striatal medium spiny neuron differentiation; thymus development IPR007087; IPR015880; IPR013087; B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) BCL11B CTIP2 RIT1 Homo sapiens (Human) TR41670_c2_g1_i2 Q0KK59 UNC79_MOUSE 5.00E-177 GO:0048149; GO:0016021; GO:0035264 behavioral response to ethanol; integral to membrane; multicellular organism growth IPR016024; IPR024855; Protein unc-79 homolog Unc79 Kiaa1409 Mus musculus (Mouse) TR41670_c3_g1_i1 P42173 UNC79_CAEEL 4.00E-38 GO:0030424; GO:0040017; GO:0042493 axon; positive regulation of locomotion; response to drug IPR024855; Uncoordinated protein 79 unc-79 C03C10.6 Caenorhabditis elegans TR41670_c3_g3_i1 Q9P2D8 UNC79_HUMAN 0 GO:0048149; GO:0016021; GO:0034220; GO:0035264; GO:0005886 behavioral response to ethanol; integral to membrane; ion transmembrane transport; multicellular organism growth; plasma membrane IPR016024; IPR024855; Protein unc-79 homolog UNC79 KIAA1409 Homo sapiens (Human) TR41671_c0_g1_i1 A6N6J5 WDR35_RAT 0 GO:0005813; GO:0042384; GO:0035085; GO:0030991; GO:0005932 centrosome; cilium assembly; cilium axoneme; intraflagellar transport particle A; microtubule basal body IPR015943; IPR001680; IPR017986; IPR017233; WD repeat-containing protein 35 (Naofen) Wdr35 Rattus norvegicus (Rat) TR41671_c0_g1_i2 Q9NRJ4 TULP4_HUMAN 9.00E-26 GO:0005737; GO:0035556; GO:0016567; GO:0007584; GO:0003700 cytoplasm; intracellular signal transduction; protein ubiquitination; response to nutrient; sequence-specific DNA binding transcription factor activity IPR001496; IPR000007; IPR025659; IPR008983; IPR015943; IPR001680; IPR017986; Protein modification; protein ubiquitination. Tubby-related protein 4 (Tubby superfamily protein) (Tubby-like protein 4) TULP4 KIAA1397 TUBL4 TUSP Homo sapiens (Human) TR41671_c0_g3_i1 A6N6J5 WDR35_RAT 0 GO:0005813; GO:0042384; GO:0035085; GO:0030991; GO:0005932 centrosome; cilium assembly; cilium axoneme; intraflagellar transport particle A; microtubule basal body IPR015943; IPR001680; IPR017986; IPR017233; WD repeat-containing protein 35 (Naofen) Wdr35 Rattus norvegicus (Rat) TR41671_c0_g3_i2 Q9HBG6 IF122_HUMAN 4.00E-07 GO:0048593; GO:0060830; GO:0060271; GO:0005737; GO:0010172; GO:0042733; GO:0035050; GO:0035721; GO:0030991; GO:0060173; GO:0005932; GO:0045879; GO:0001843; GO:0032391; GO:0060831 Q9Q2G4 camera-type eye morphogenesis; ciliary receptor clustering involved in smoothened signaling pathway; cilium morphogenesis; cytoplasm; embryonic body morphogenesis; embryonic digit morphogenesis; embryonic heart tube development; intraflagellar retrograde transport; intraflagellar transport particle A; limb development; microtubule basal body; negative regulation of smoothened signaling pathway; neural tube closure; photoreceptor connecting cilium; smoothened signaling pathway involved in dorsal/ventral neural tube patterning IPR011990; IPR015943; IPR001680; IPR017986; Intraflagellar transport protein 122 homolog (WD repeat-containing protein 10) (WD repeat-containing protein 140) IFT122 SPG WDR10 WDR140 Homo sapiens (Human) TR41672_c2_g1_i1 O70528 5HT4R_CAVPO 6.00E-66 GO:0005768; GO:0005887; GO:0032098; GO:0004993; GO:0007210; GO:0007268 endosome; integral to plasma membrane; regulation of appetite; serotonin receptor activity; serotonin receptor signaling pathway; synaptic transmission IPR001520; IPR000276; IPR017452; 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) HTR4 Cavia porcellus (Guinea pig) TR41672_c2_g1_i10 Q98982 NK1R_LITCT 2.00E-06 GO:0016021; GO:0005886; GO:0004995; GO:0007217 integral to membrane; plasma membrane; tachykinin receptor activity; tachykinin receptor signaling pathway IPR000276; IPR017452; IPR001681; IPR000046; Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1) TACR1 TAC1R Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) TR41672_c2_g1_i12 P42289 DRD1_XENLA 2.00E-32 GO:0004952; GO:0007212; GO:0005887; GO:0010579; GO:0042311 dopamine neurotransmitter receptor activity; dopamine receptor signaling pathway; integral to plasma membrane; positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway; vasodilation IPR001413; IPR000497; IPR000929; IPR000276; IPR017452; D(1A) dopamine receptor (Dopamine D1 receptor) drd1 Xenopus laevis (African clawed frog) TR41672_c2_g1_i14 Q60484 5HT1D_CAVPO 2.00E-31 GO:0007193; GO:0005887; GO:0014827; GO:0050795; GO:0040012; GO:0009636; GO:0051378; GO:0004993; GO:0007268; GO:0042310 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; integral to plasma membrane; intestine smooth muscle contraction; regulation of behavior; regulation of locomotion; response to toxic substance; serotonin binding; serotonin receptor activity; synaptic transmission; vasoconstriction IPR000505; IPR002231; IPR000276; IPR017452; 5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin receptor 1D) HTR1D Cavia porcellus (Guinea pig) TR41672_c2_g1_i16 O70528 5HT4R_CAVPO 6.00E-66 GO:0005768; GO:0005887; GO:0032098; GO:0004993; GO:0007210; GO:0007268 endosome; integral to plasma membrane; regulation of appetite; serotonin receptor activity; serotonin receptor signaling pathway; synaptic transmission IPR001520; IPR000276; IPR017452; 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) HTR4 Cavia porcellus (Guinea pig) TR41672_c2_g1_i17 O70528 5HT4R_CAVPO 6.00E-66 GO:0005768; GO:0005887; GO:0032098; GO:0004993; GO:0007210; GO:0007268 endosome; integral to plasma membrane; regulation of appetite; serotonin receptor activity; serotonin receptor signaling pathway; synaptic transmission IPR001520; IPR000276; IPR017452; 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) HTR4 Cavia porcellus (Guinea pig) TR41672_c2_g1_i3 O70528 5HT4R_CAVPO 3.00E-66 GO:0005768; GO:0005887; GO:0032098; GO:0004993; GO:0007210; GO:0007268 endosome; integral to plasma membrane; regulation of appetite; serotonin receptor activity; serotonin receptor signaling pathway; synaptic transmission IPR001520; IPR000276; IPR017452; 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) HTR4 Cavia porcellus (Guinea pig) TR41672_c2_g1_i4 P18762 ADRB2_MOUSE 6.00E-42 GO:0007190; GO:0008179; GO:0007189; GO:0016324; GO:0004941; GO:0045453; GO:0050873; GO:0002032; GO:0002024; GO:0031649; GO:0005887; GO:0040015; GO:0045986; GO:0051380; GO:0005634; GO:0043410; GO:0030501; GO:0031398; GO:0045944; GO:0015459; GO:0042803; GO:0043235; GO:0006898; GO:0002028; GO:0042312; GO:0009409; GO:0002025 activation of adenylate cyclase activity; adenylate cyclase binding; adenylate cyclase-activating G-protein coupled receptor signaling pathway; apical plasma membrane; beta2-adrenergic receptor activity; bone resorption; brown fat cell differentiation; desensitization of G-protein coupled receptor protein signaling pathway by arrestin; diet induced thermogenesis; heat generation; integral to plasma membrane; negative regulation of multicellular organism growth; negative regulation of smooth muscle contraction; norepinephrine binding; nucleus; positive regulation of MAPK cascade; positive regulation of bone mineralization; positive regulation of protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter; potassium channel regulator activity; protein homodimerization activity; receptor complex; receptor-mediated endocytosis; regulation of sodium ion transport; regulation of vasodilation; response to cold; vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IPR002233; IPR000332; IPR000276; IPR017452; Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) Adrb2 Adrb2r Mus musculus (Mouse) TR41672_c2_g1_i5 Q98982 NK1R_LITCT 2.00E-06 GO:0016021; GO:0005886; GO:0004995; GO:0007217 integral to membrane; plasma membrane; tachykinin receptor activity; tachykinin receptor signaling pathway IPR000276; IPR017452; IPR001681; IPR000046; Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1) TACR1 TAC1R Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) TR41672_c2_g1_i7 O70528 5HT4R_CAVPO 4.00E-66 GO:0005768; GO:0005887; GO:0032098; GO:0004993; GO:0007210; GO:0007268 endosome; integral to plasma membrane; regulation of appetite; serotonin receptor activity; serotonin receptor signaling pathway; synaptic transmission IPR001520; IPR000276; IPR017452; 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) HTR4 Cavia porcellus (Guinea pig) TR41672_c2_g1_i9 O70431 ADRB2_MERUN 7.00E-34 GO:0007189; GO:0071875; GO:0004941; GO:0016021; GO:0005886; GO:0006940; GO:0042312 adenylate cyclase-activating G-protein coupled receptor signaling pathway; adrenergic receptor signaling pathway; beta2-adrenergic receptor activity; integral to membrane; plasma membrane; regulation of smooth muscle contraction; regulation of vasodilation IPR002233; IPR000332; IPR000276; IPR017452; Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) (Fragment) ADRB2 Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) TR41673_c1_g1_i1 A8XP97 UNC36_CAEBR 1.00E-39 GO:0040011; GO:0018991; GO:0043050; GO:0007210; GO:0005245; GO:0005891 locomotion; oviposition; pharyngeal pumping; serotonin receptor signaling pathway; voltage-gated calcium channel activity; voltage-gated calcium channel complex IPR004010; IPR013608; IPR002035; Voltage-dependent calcium channel unc-36 (Pharyngeal calcium channel subunit alpha-2) (Uncoordinated protein 36) unc-36 CBG16666 Caenorhabditis briggsae TR41673_c1_g1_i2 P54289 CA2D1_HUMAN 5.00E-150 GO:0030315; GO:0046872; GO:0051924; GO:0016529; GO:0005245; GO:0005891 T-tubule; metal ion binding; regulation of calcium ion transport; sarcoplasmic reticulum; voltage-gated calcium channel activity; voltage-gated calcium channel complex IPR004010; IPR013680; IPR013608; IPR002035; Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1] CACNA2D1 CACNL2A CCHL2A MHS3 Homo sapiens (Human) TR41674_c5_g1_i2 Q7Z408 CSMD2_HUMAN 3.00E-13 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2) CSMD2 KIAA1884 Homo sapiens (Human) TR41674_c5_g1_i3 Q96PZ7 CSMD1_HUMAN 2.00E-13 GO:0016021 integral to membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 1 (CUB and sushi multiple domains protein 1) CSMD1 KIAA1890 UNQ5952/PRO19863 Homo sapiens (Human) TR41674_c5_g1_i4 Q80T79 CSMD3_MOUSE 4.00E-12 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 3 (CUB and sushi multiple domains protein 3) Csmd3 Kiaa1894 Mus musculus (Mouse) TR41675_c0_g4_i1 B1AWJ5 TMM8B_MOUSE 3.00E-77 GO:0009986; GO:0007160; GO:0005783; GO:0016021; GO:0005739; GO:0005634; GO:0005886; GO:0040008 cell surface; cell-matrix adhesion; endoplasmic reticulum; integral to membrane; mitochondrion; nucleus; plasma membrane; regulation of growth IPR021910; IPR000742; IPR013032; Transmembrane protein 8B (Protein NGX6) Tmem8b Mus musculus (Mouse) TR41675_c0_g4_i2 A6NDV4 TMM8B_HUMAN 1.00E-78 GO:0009986; GO:0007160; GO:0005783; GO:0016021; GO:0005739; GO:0005634; GO:0005886; GO:0040008; GO:0007346 cell surface; cell-matrix adhesion; endoplasmic reticulum; integral to membrane; mitochondrion; nucleus; plasma membrane; regulation of growth; regulation of mitotic cell cycle IPR021910; IPR000742; IPR013032; Transmembrane protein 8B (Nasopharyngeal carcinoma-associated gene 6 protein) (Protein NAG-5) (Protein NGX6) TMEM8B C9orf127 NGX6 Homo sapiens (Human) TR41675_c0_g4_i5 A6NDV4 TMM8B_HUMAN 1.00E-61 GO:0009986; GO:0007160; GO:0005783; GO:0016021; GO:0005739; GO:0005634; GO:0005886; GO:0040008; GO:0007346 cell surface; cell-matrix adhesion; endoplasmic reticulum; integral to membrane; mitochondrion; nucleus; plasma membrane; regulation of growth; regulation of mitotic cell cycle IPR021910; IPR000742; IPR013032; Transmembrane protein 8B (Nasopharyngeal carcinoma-associated gene 6 protein) (Protein NAG-5) (Protein NGX6) TMEM8B C9orf127 NGX6 Homo sapiens (Human) TR41676_c2_g1_i2 Q69ZX6 MOR2A_MOUSE 0 GO:0005524; GO:0008270 ATP binding; zinc ion binding IPR003594; IPR011124; MORC family CW-type zinc finger protein 2A (Zinc finger CW-type coiled-coil domain protein 1) Morc2a Kiaa0852 Zcwcc1 Mus musculus (Mouse) TR41676_c2_g1_i4 Q14149 MORC3_HUMAN 1.00E-35 GO:0005524; GO:0016605; GO:0016235; GO:0007569; GO:0045111; GO:0051457; GO:0048147; GO:0018105; GO:0009791; GO:0050821; GO:0008270 ATP binding; PML body; aggresome; cell aging; intermediate filament cytoskeleton; maintenance of protein location in nucleus; negative regulation of fibroblast proliferation; peptidyl-serine phosphorylation; post-embryonic development; protein stabilization; zinc ion binding IPR003594; IPR011124; MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled-coil domain protein 3) MORC3 KIAA0136 ZCWCC3 Homo sapiens (Human) TR41676_c2_g1_i6 Q69ZX6 MOR2A_MOUSE 1.00E-126 GO:0005524; GO:0008270 ATP binding; zinc ion binding IPR003594; IPR011124; MORC family CW-type zinc finger protein 2A (Zinc finger CW-type coiled-coil domain protein 1) Morc2a Kiaa0852 Zcwcc1 Mus musculus (Mouse) TR41678_c0_g2_i1 Q9BHM6 OCDH_PECMA 1.00E-113 GO:0047830; GO:0051287; GO:0005737; GO:0046168; GO:0016616 "D-octopine dehydrogenase activity; NAD binding; cytoplasm; glycerol-3-phosphate catabolic process; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" IPR008927; IPR013328; IPR011128; IPR016040; IPR003421; Octopine dehydrogenase (OcDH) (EC 1.5.1.11) odh1 Pecten maximus (King scallop) (Pilgrim's clam) TR41679_c1_g3_i1 Q0P5B3 RBTN1_BOVIN 2.00E-67 GO:0000122; GO:0005634; GO:0045944; GO:0008270 negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of transcription from RNA polymerase II promoter; zinc ion binding IPR001781; Rhombotin-1 (LIM domain only protein 1) (LMO-1) LMO1 RBTN1 Bos taurus (Bovine) TR4168_c0_g1_i1 Q8BHZ4 ZN592_MOUSE 4.00E-08 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; Zinc finger protein 592 (Zfp-592) Znf592 Kiaa0211 Zfp592 Mus musculus (Mouse) TR41680_c5_g1_i2 P34897 GLYM_HUMAN 0 GO:0008732; GO:0006564; GO:0016597; GO:0003682; GO:0019264; GO:0004372; GO:0015630; GO:0005743; GO:0005758; GO:0042645; GO:0006730; GO:0008284; GO:0051289; GO:0030170; GO:0035999 L-allo-threonine aldolase activity; L-serine biosynthetic process; amino acid binding; chromatin binding; glycine biosynthetic process from serine; glycine hydroxymethyltransferase activity; microtubule cytoskeleton; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial nucleoid; one-carbon metabolic process; positive regulation of cell proliferation; protein homotetramerization; pyridoxal phosphate binding; tetrahydrofolate interconversion IPR015424; IPR015421; IPR015422; IPR001085; IPR019798; One-carbon metabolism; tetrahydrofolate interconversion. "Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)" SHMT2 Homo sapiens (Human) TR41680_c5_g1_i5 P34897 GLYM_HUMAN 0 GO:0008732; GO:0006564; GO:0016597; GO:0003682; GO:0019264; GO:0004372; GO:0015630; GO:0005743; GO:0005758; GO:0042645; GO:0006730; GO:0008284; GO:0051289; GO:0030170; GO:0035999 L-allo-threonine aldolase activity; L-serine biosynthetic process; amino acid binding; chromatin binding; glycine biosynthetic process from serine; glycine hydroxymethyltransferase activity; microtubule cytoskeleton; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial nucleoid; one-carbon metabolic process; positive regulation of cell proliferation; protein homotetramerization; pyridoxal phosphate binding; tetrahydrofolate interconversion IPR015424; IPR015421; IPR015422; IPR001085; IPR019798; One-carbon metabolism; tetrahydrofolate interconversion. "Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)" SHMT2 Homo sapiens (Human) TR41681_c0_g3_i3 O00429 DNM1L_HUMAN 1.00E-20 GO:0005525; GO:0003924; GO:0005794; GO:0006921; GO:0005829; GO:0003374; GO:0012505; GO:0090149; GO:0005874; GO:0043653; GO:0005741; GO:0070584; GO:0070266; GO:0048471; GO:0005777; GO:0016559; GO:2001244; GO:0090141; GO:0050714; GO:0090200; GO:0043234; GO:0042803; GO:0051289; GO:1900063 P03372; Q5S007; Q96C03; Q9NQG6 GTP binding; GTPase activity; Golgi apparatus; cellular component disassembly involved in execution phase of apoptosis; cytosol; dynamin polymerization involved in mitochondrial fission; endomembrane system; membrane fission involved in mitochondrial fission; microtubule; mitochondrial fragmentation involved in apoptotic process; mitochondrial outer membrane; mitochondrion morphogenesis; necroptosis; perinuclear region of cytoplasm; peroxisome; peroxisome fission; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of mitochondrial fission; positive regulation of protein secretion; positive regulation of release of cytochrome c from mitochondria; protein complex; protein homodimerization activity; protein homotetramerization; regulation of peroxisome organization IPR000375; IPR001401; IPR019762; IPR022812; IPR003130; IPR020850; IPR027417; Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) DNM1L DLP1 DRP1 Homo sapiens (Human) TR41681_c0_g4_i1 O00429 DNM1L_HUMAN 0 GO:0005525; GO:0003924; GO:0005794; GO:0006921; GO:0005829; GO:0003374; GO:0012505; GO:0090149; GO:0005874; GO:0043653; GO:0005741; GO:0070584; GO:0070266; GO:0048471; GO:0005777; GO:0016559; GO:2001244; GO:0090141; GO:0050714; GO:0090200; GO:0043234; GO:0042803; GO:0051289; GO:1900063 P03372; Q5S007; Q96C03; Q9NQG6 GTP binding; GTPase activity; Golgi apparatus; cellular component disassembly involved in execution phase of apoptosis; cytosol; dynamin polymerization involved in mitochondrial fission; endomembrane system; membrane fission involved in mitochondrial fission; microtubule; mitochondrial fragmentation involved in apoptotic process; mitochondrial outer membrane; mitochondrion morphogenesis; necroptosis; perinuclear region of cytoplasm; peroxisome; peroxisome fission; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of mitochondrial fission; positive regulation of protein secretion; positive regulation of release of cytochrome c from mitochondria; protein complex; protein homodimerization activity; protein homotetramerization; regulation of peroxisome organization IPR000375; IPR001401; IPR019762; IPR022812; IPR003130; IPR020850; IPR027417; Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) DNM1L DLP1 DRP1 Homo sapiens (Human) TR41682_c0_g2_i1 Q5ZI87 TBCD_CHICK 2.00E-179 GO:0005096; GO:0005912; GO:0034333; GO:0048487; GO:0005737; GO:0016328; GO:0010812; GO:0031115; GO:0007023; GO:0005923; GO:0070830 GTPase activator activity; adherens junction; adherens junction assembly; beta-tubulin binding; cytoplasm; lateral plasma membrane; negative regulation of cell-substrate adhesion; negative regulation of microtubule polymerization; post-chaperonin tubulin folding pathway; tight junction; tight junction assembly IPR011989; IPR016024; IPR022577; Tubulin-specific chaperone D (Beta-tubulin cofactor D) (Tubulin-folding cofactor D) TBCD RCJMB04_29e8 Gallus gallus (Chicken) TR41683_c2_g1_i3 Q8JZW5 SH2D5_MOUSE 2.00E-10 IPR000980; SH2 domain-containing protein 5 Sh2d5 Mus musculus (Mouse) TR41683_c2_g1_i4 A5PMU4 ANS1B_DANRE 9.00E-07 GO:0005737 cytoplasm IPR002110; IPR020683; IPR011993; IPR006020; IPR001660; IPR013761; IPR011510; IPR021129; Ankyrin repeat and sterile alpha motif domain-containing protein 1B anks1b si:ch211-211o1.2 si:dkey-11k24.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR41683_c2_g1_i5 Q6ZV89 SH2D5_HUMAN 7.00E-22 IPR011993; IPR006020; IPR000980; SH2 domain-containing protein 5 SH2D5 Homo sapiens (Human) TR41683_c3_g1_i1 Q32PJ7 TENS4_BOVIN 2.00E-14 GO:0006915; GO:0005737; GO:0005856; GO:0005925 apoptotic process; cytoplasm; cytoskeleton; focal adhesion IPR011993; IPR013625; IPR000980; Tensin-4 TNS4 Bos taurus (Bovine) TR41683_c3_g1_i3 Q32PJ7 TENS4_BOVIN 2.00E-14 GO:0006915; GO:0005737; GO:0005856; GO:0005925 apoptotic process; cytoplasm; cytoskeleton; focal adhesion IPR011993; IPR013625; IPR000980; Tensin-4 TNS4 Bos taurus (Bovine) TR41685_c0_g4_i2 Q62733 LAP2_RAT 3.00E-07 GO:0003677; GO:0000785; GO:0016021; GO:0005521; GO:0031468; GO:0005637; GO:0006355 "DNA binding; chromatin; integral to membrane; lamin binding; nuclear envelope reassembly; nuclear inner membrane; regulation of transcription, DNA-dependent" IPR013146; IPR011015; IPR003887; "Lamina-associated polypeptide 2, isoform beta (Thymopoietin isoform beta) (TP beta)" Tmpo Lap2 Rattus norvegicus (Rat) TR41686_c0_g3_i3 Q05893 PCKG_ASCSU 0 GO:0005525; GO:0006094; GO:0046872; GO:0004613 GTP binding; gluconeogenesis; metal ion binding; phosphoenolpyruvate carboxykinase (GTP) activity IPR018091; IPR013035; IPR008209; IPR008210; Phosphoenolpyruvate carboxykinase [GTP] (PEPCK) (EC 4.1.1.32) (Phosphoenolpyruvate carboxylase) PEPCK Ascaris suum (Pig roundworm) (Ascaris lumbricoides) TR41686_c0_g3_i4 A4FQV7 PCKG_SACEN 1.00E-129 GO:0005525; GO:0005737; GO:0006094; GO:0030145; GO:0004613 GTP binding; cytoplasm; gluconeogenesis; manganese ion binding; phosphoenolpyruvate carboxykinase (GTP) activity IPR018091; IPR013035; IPR008209; IPR008210; Carbohydrate biosynthesis; gluconeogenesis. Phosphoenolpyruvate carboxykinase [GTP] (PEP carboxykinase) (PEPCK) (EC 4.1.1.32) (Phosphoenolpyruvate carboxylase) pckG SACE_7274 Saccharopolyspora erythraea (strain NRRL 23338) TR41687_c0_g1_i1 Q5R4W4 CF062_PONAB 1.00E-98 IPR027903; Uncharacterized protein C6orf62 homolog Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41687_c0_g1_i7 Q5R4W4 CF062_PONAB 1.00E-101 IPR027903; Uncharacterized protein C6orf62 homolog Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41688_c0_g2_i3 Q07813 BAX_MOUSE 8.00E-31 GO:0001783; GO:0001782; GO:0002358; GO:0002352; GO:0097144; GO:0060011; GO:0001777; GO:0006919; GO:0008635; GO:0097296; GO:0006309; GO:1902263; GO:1902262; GO:0001974; GO:0034644; GO:0071310; GO:0021987; GO:0015267; GO:0006922; GO:0005829; GO:0045136; GO:0005789; GO:0010248; GO:0097192; GO:0008625; GO:0009566; GO:0007281; GO:0035234; GO:0006687; GO:0048873; GO:0021854; GO:0072332; GO:0008630; GO:0070059; GO:0001822; GO:0008289; GO:0043653; GO:0008053; GO:0005741; GO:0005757; GO:0002262; GO:2001234; GO:0048147; GO:0043524; GO:0033137; GO:0032091; GO:0051402; GO:0001764; GO:0030264; GO:0005634; GO:0042475; GO:0001541; GO:0002904; GO:0060058; GO:0048087; GO:1900103; GO:2001241; GO:2001244; GO:0043525; GO:0032461; GO:0090200; GO:0051281; GO:0048597; GO:0042803; GO:0051260; GO:0001844; GO:0032471; GO:0051726; GO:0033599; GO:1902445; GO:0006808; GO:0043496; GO:0001836; GO:0032976; GO:0001101; GO:0048678; GO:0010332; GO:0009651; GO:0009636; GO:0060041; GO:1990009; GO:0046666; GO:0048515; GO:0070242; GO:0006927; GO:0060068 P10417; O75460 B cell apoptotic process; B cell homeostasis; B cell homeostatic proliferation; B cell negative selection; BAX complex; Sertoli cell proliferation; T cell homeostatic proliferation; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; apoptotic DNA fragmentation; apoptotic process involved in embryonic digit morphogenesis; apoptotic process involved in patterning of blood vessels; blood vessel remodeling; cellular response to UV; cellular response to organic substance; cerebral cortex development; channel activity; cleavage of lamin involved in execution phase of apoptosis; cytosol; development of secondary sexual characteristics; endoplasmic reticulum membrane; establishment or maintenance of transmembrane electrochemical gradient; extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; fertilization; germ cell development; germ cell programmed cell death; glycosphingolipid metabolic process; homeostasis of number of cells within a tissue; hypothalamus development; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; kidney development; lipid binding; mitochondrial fragmentation involved in apoptotic process; mitochondrial fusion; mitochondrial outer membrane; mitochondrial permeability transition pore complex; myeloid cell homeostasis; negative regulation of apoptotic signaling pathway; negative regulation of fibroblast proliferation; negative regulation of neuron apoptotic process; negative regulation of peptidyl-serine phosphorylation; negative regulation of protein binding; neuron apoptotic process; neuron migration; nuclear fragmentation involved in apoptotic nuclear change; nucleus; odontogenesis of dentin-containing tooth; ovarian follicle development; positive regulation of B cell apoptotic process; positive regulation of apoptotic process involved in mammary gland involution; positive regulation of developmental pigmentation; positive regulation of endoplasmic reticulum unfolded protein response; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of neuron apoptotic process; positive regulation of protein oligomerization; positive regulation of release of cytochrome c from mitochondria; positive regulation of release of sequestered calcium ion into cytosol; post-embryonic camera-type eye morphogenesis; protein homodimerization activity; protein homooligomerization; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; reduction of endoplasmic reticulum calcium ion concentration; regulation of cell cycle; regulation of mammary gland epithelial cell proliferation; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death; regulation of nitrogen utilization; regulation of protein homodimerization activity; release of cytochrome c from mitochondria; release of matrix enzymes from mitochondria; response to acid; response to axon injury; response to gamma radiation; response to salt stress; response to toxic substance; retina development in camera-type eye; retinal cell apoptotic process; retinal cell programmed cell death; spermatid differentiation; thymocyte apoptotic process; transformed cell apoptotic process; vagina development IPR026304; IPR002475; IPR020717; IPR020726; IPR020728; IPR026298; Apoptosis regulator BAX Bax Mus musculus (Mouse) TR41688_c0_g2_i4 Q91828 AR11_XENLA 6.00E-10 GO:0006915; GO:0016021; GO:0042981 apoptotic process; integral to membrane; regulation of apoptotic process IPR013279; IPR002475; IPR004725; IPR020717; IPR020726; IPR003093; IPR026298; Apoptosis regulator R11 (XR11) Xenopus laevis (African clawed frog) TR41688_c0_g2_i5 Q07813 BAX_MOUSE 9.00E-31 GO:0001783; GO:0001782; GO:0002358; GO:0002352; GO:0097144; GO:0060011; GO:0001777; GO:0006919; GO:0008635; GO:0097296; GO:0006309; GO:1902263; GO:1902262; GO:0001974; GO:0034644; GO:0071310; GO:0021987; GO:0015267; GO:0006922; GO:0005829; GO:0045136; GO:0005789; GO:0010248; GO:0097192; GO:0008625; GO:0009566; GO:0007281; GO:0035234; GO:0006687; GO:0048873; GO:0021854; GO:0072332; GO:0008630; GO:0070059; GO:0001822; GO:0008289; GO:0043653; GO:0008053; GO:0005741; GO:0005757; GO:0002262; GO:2001234; GO:0048147; GO:0043524; GO:0033137; GO:0032091; GO:0051402; GO:0001764; GO:0030264; GO:0005634; GO:0042475; GO:0001541; GO:0002904; GO:0060058; GO:0048087; GO:1900103; GO:2001241; GO:2001244; GO:0043525; GO:0032461; GO:0090200; GO:0051281; GO:0048597; GO:0042803; GO:0051260; GO:0001844; GO:0032471; GO:0051726; GO:0033599; GO:1902445; GO:0006808; GO:0043496; GO:0001836; GO:0032976; GO:0001101; GO:0048678; GO:0010332; GO:0009651; GO:0009636; GO:0060041; GO:1990009; GO:0046666; GO:0048515; GO:0070242; GO:0006927; GO:0060068 P10417; O75460 B cell apoptotic process; B cell homeostasis; B cell homeostatic proliferation; B cell negative selection; BAX complex; Sertoli cell proliferation; T cell homeostatic proliferation; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; apoptotic DNA fragmentation; apoptotic process involved in embryonic digit morphogenesis; apoptotic process involved in patterning of blood vessels; blood vessel remodeling; cellular response to UV; cellular response to organic substance; cerebral cortex development; channel activity; cleavage of lamin involved in execution phase of apoptosis; cytosol; development of secondary sexual characteristics; endoplasmic reticulum membrane; establishment or maintenance of transmembrane electrochemical gradient; extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; fertilization; germ cell development; germ cell programmed cell death; glycosphingolipid metabolic process; homeostasis of number of cells within a tissue; hypothalamus development; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; kidney development; lipid binding; mitochondrial fragmentation involved in apoptotic process; mitochondrial fusion; mitochondrial outer membrane; mitochondrial permeability transition pore complex; myeloid cell homeostasis; negative regulation of apoptotic signaling pathway; negative regulation of fibroblast proliferation; negative regulation of neuron apoptotic process; negative regulation of peptidyl-serine phosphorylation; negative regulation of protein binding; neuron apoptotic process; neuron migration; nuclear fragmentation involved in apoptotic nuclear change; nucleus; odontogenesis of dentin-containing tooth; ovarian follicle development; positive regulation of B cell apoptotic process; positive regulation of apoptotic process involved in mammary gland involution; positive regulation of developmental pigmentation; positive regulation of endoplasmic reticulum unfolded protein response; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of neuron apoptotic process; positive regulation of protein oligomerization; positive regulation of release of cytochrome c from mitochondria; positive regulation of release of sequestered calcium ion into cytosol; post-embryonic camera-type eye morphogenesis; protein homodimerization activity; protein homooligomerization; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; reduction of endoplasmic reticulum calcium ion concentration; regulation of cell cycle; regulation of mammary gland epithelial cell proliferation; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death; regulation of nitrogen utilization; regulation of protein homodimerization activity; release of cytochrome c from mitochondria; release of matrix enzymes from mitochondria; response to acid; response to axon injury; response to gamma radiation; response to salt stress; response to toxic substance; retina development in camera-type eye; retinal cell apoptotic process; retinal cell programmed cell death; spermatid differentiation; thymocyte apoptotic process; transformed cell apoptotic process; vagina development IPR026304; IPR002475; IPR020717; IPR020726; IPR020728; IPR026298; Apoptosis regulator BAX Bax Mus musculus (Mouse) TR41688_c0_g2_i7 Q91828 AR11_XENLA 6.00E-10 GO:0006915; GO:0016021; GO:0042981 apoptotic process; integral to membrane; regulation of apoptotic process IPR013279; IPR002475; IPR004725; IPR020717; IPR020726; IPR003093; IPR026298; Apoptosis regulator R11 (XR11) Xenopus laevis (African clawed frog) TR41689_c3_g3_i1 P28683 OPSG_CHICK 3.00E-11 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR027430; IPR000732; IPR019477; Green-sensitive opsin (Green cone photoreceptor pigment) PRA1 Gallus gallus (Chicken) TR41690_c1_g2_i1 Q7Z3U7 MON2_HUMAN 0 GO:0005086; GO:0006895; GO:0030036; GO:0015031; GO:0005802 Q9UJY5 ARF guanyl-nucleotide exchange factor activity; Golgi to endosome transport; actin cytoskeleton organization; protein transport; trans-Golgi network IPR011989; IPR016024; IPR015403; IPR026829; Protein MON2 homolog (Protein SF21) MON2 KIAA1040 SF21 Homo sapiens (Human) TR41691_c0_g3_i1 Q3TCX3 K0907_MOUSE 5.00E-66 GO:0003723 RNA binding UPF0469 protein KIAA0907 Kiaa0907 Mus musculus (Mouse) TR41691_c0_g3_i2 Q8H0U8 RH42_ARATH 1.00E-06 GO:0005524; GO:0008026; GO:0003723 ATP binding; ATP-dependent helicase activity; RNA binding IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; DEAD-box ATP-dependent RNA helicase 42 (EC 3.6.4.13) RH42 At1g20920 F9H16.10 Arabidopsis thaliana (Mouse-ear cress) TR41692_c4_g2_i1 Q92900 RENT1_HUMAN 2.00E-55 GO:0005524; GO:0004004; GO:0003677; GO:0006281; GO:0006260; GO:0003723; GO:0000785; GO:0003682; GO:0000932; GO:0005829; GO:0009048; GO:0035145; GO:0010467; GO:0071044; GO:0006406; GO:0000184; GO:0006449; GO:0044530; GO:0008270 Q96AP0; Q9NPI6; Q8IU60; Q14152; P15170; Q8IYD1; Q9NPJ4; Q08491; Q9UPR3; Q86US8; O95793; O14746; Q9HAU5; Q9H1J1; Q9BZI7 "ATP binding; ATP-dependent RNA helicase activity; DNA binding; DNA repair; DNA replication; RNA binding; chromatin; chromatin binding; cytoplasmic mRNA processing body; cytosol; dosage compensation by inactivation of X chromosome; exon-exon junction complex; gene expression; histone mRNA catabolic process; mRNA export from nucleus; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; regulation of translational termination; supraspliceosomal complex; zinc ion binding" IPR027417; IPR018999; Regulator of nonsense transcripts 1 (EC 3.6.4.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) UPF1 KIAA0221 RENT1 Homo sapiens (Human) TR41693_c1_g1_i2 P98153 IDD_HUMAN 3.00E-08 GO:0030246; GO:0007155; GO:0016021; GO:0009887 carbohydrate binding; cell adhesion; integral to membrane; organ morphogenesis IPR001304; IPR016186; IPR016187; IPR023415; IPR002172; IPR001007; Integral membrane protein DGCR2/IDD DGCR2 IDD KIAA0163 Homo sapiens (Human) TR41693_c1_g1_i4 P98154 IDD_MOUSE 5.00E-10 GO:0030246; GO:0007155; GO:0016021; GO:0016020; GO:0042493 carbohydrate binding; cell adhesion; integral to membrane; membrane; response to drug IPR001304; IPR016186; IPR016187; IPR023415; IPR002172; IPR001007; Integral membrane protein DGCR2/IDD (Seizure-related membrane-bound adhesion protein) Dgcr2 Dgsc Idd Sez-12 Sez12 Mus musculus (Mouse) TR41693_c1_g3_i1 Q868T3 CCAPR_DROME 1.00E-16 GO:0018990; GO:0005887; GO:0008188; GO:0005000 "ecdysis, chitin-based cuticle; integral to plasma membrane; neuropeptide receptor activity; vasopressin receptor activity" IPR000276; IPR017452; IPR001817; Cardioacceleratory peptide receptor CcapR CG6111 Drosophila melanogaster (Fruit fly) TR41694_c2_g1_i1 Q6DN14 MCTP1_HUMAN 1.00E-61 GO:0005509; GO:0019722; GO:0016021 calcium ion binding; calcium-mediated signaling; integral to membrane IPR000008; IPR013583; Multiple C2 and transmembrane domain-containing protein 1 MCTP1 Homo sapiens (Human) TR41694_c3_g1_i1 Q13867 BLMH_HUMAN 0 GO:0004177; GO:0002474; GO:0004180; GO:0004197; GO:0005829; GO:0005634; GO:0000209; GO:0006508; GO:0042493; GO:0009636 P05067-4 aminopeptidase activity; antigen processing and presentation of peptide antigen via MHC class I; carboxypeptidase activity; cysteine-type endopeptidase activity; cytosol; nucleus; protein polyubiquitination; proteolysis; response to drug; response to toxic substance IPR000169; IPR004134; Bleomycin hydrolase (BH) (BLM hydrolase) (BMH) (EC 3.4.22.40) BLMH Homo sapiens (Human) TR41694_c3_g2_i1 Q6DN12 MCTP2_HUMAN 4.00E-51 GO:0005509; GO:0019722; GO:0016021 calcium ion binding; calcium-mediated signaling; integral to membrane IPR000008; IPR013583; Multiple C2 and transmembrane domain-containing protein 2 MCTP2 Homo sapiens (Human) TR41695_c0_g1_i1 O96064 MYSP_MYTGA 0 GO:0003774; GO:0030016; GO:0032982 motor activity; myofibril; myosin filament IPR015650; IPR002928; Paramyosin Mytilus galloprovincialis (Mediterranean mussel) TR41695_c0_g1_i2 O96064 MYSP_MYTGA 0 GO:0003774; GO:0030016; GO:0032982 motor activity; myofibril; myosin filament IPR015650; IPR002928; Paramyosin Mytilus galloprovincialis (Mediterranean mussel) TR41695_c1_g1_i1 P53040 TAF6_YEAST 7.00E-53 GO:0001102; GO:0051123; GO:0000124; GO:0046695; GO:0003682; GO:0005829; GO:0016573; GO:0032947; GO:0051090; GO:0005669 Itself; P35817; Q12060; P46677; Q12030; P38129; Q05027 RNA polymerase II activating transcription factor binding; RNA polymerase II transcriptional preinitiation complex assembly; SAGA complex; SLIK (SAGA-like) complex; chromatin binding; cytosol; histone acetylation; protein complex scaffold; regulation of sequence-specific DNA binding transcription factor activity; transcription factor TFIID complex IPR016024; IPR011442; IPR009072; IPR004823; Transcription initiation factor TFIID subunit 6 (TBP-associated factor 6) (TBP-associated factor 60 kDa) (TAFII-60) (TAFII60) TAF6 TAF60 YGL112C G2985 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41695_c1_g1_i2 Q91857 TAF6_XENLA 2.00E-168 GO:0006352; GO:0071339; GO:0051090 "DNA-dependent transcription, initiation; MLL1 complex; regulation of sequence-specific DNA binding transcription factor activity" IPR016024; IPR011442; IPR009072; IPR004823; Transcription initiation factor TFIID subunit 6 (xTAF6) (Transcription initiation factor TFIID 60 kDa subunit) (TAF(II)60) (TAFII-60) (TAFII60) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) taf6 Xenopus laevis (African clawed frog) TR41696_c0_g1_i1 Q5XPI4 RN123_HUMAN 5.00E-143 GO:0005737; GO:0016874; GO:0016567; GO:0008270 cytoplasm; ligase activity; protein ubiquitination; zinc ion binding IPR001870; IPR008985; IPR018355; IPR003877; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF123 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) RNF123 KPC1 FP1477 Homo sapiens (Human) TR41696_c0_g1_i2 Q5XPI3 RN123_MOUSE 4.00E-67 GO:0005737; GO:0016874; GO:0016567; GO:0008270 cytoplasm; ligase activity; protein ubiquitination; zinc ion binding IPR001870; IPR008985; IPR018355; IPR003877; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF123 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) Rnf123 Kpc1 Mus musculus (Mouse) TR41697_c1_g2_i4 Q8BMG8 MFTC_MOUSE 1.00E-09 GO:0016021; GO:0005743; GO:0005739; GO:0006810 integral to membrane; mitochondrial inner membrane; mitochondrion; transport IPR018108; IPR023395; Mitochondrial folate transporter/carrier (Solute carrier family 25 member 32) Slc25a32 Mftc Mus musculus (Mouse) TR41697_c1_g2_i9 Q8BMG8 MFTC_MOUSE 5.00E-49 GO:0016021; GO:0005743; GO:0005739; GO:0006810 integral to membrane; mitochondrial inner membrane; mitochondrion; transport IPR018108; IPR023395; Mitochondrial folate transporter/carrier (Solute carrier family 25 member 32) Slc25a32 Mftc Mus musculus (Mouse) TR41698_c0_g1_i5 Q54YG9 TCEA1_DICDI 7.00E-25 GO:0003677; GO:0005654; GO:0032784; GO:0006357; GO:0006368; GO:0008270 "DNA binding; nucleoplasm; regulation of DNA-dependent transcription, elongation; regulation of transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; zinc ion binding" IPR016492; IPR003618; IPR017923; IPR001222; Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor tf2s) tcea1 tf2s DDB_G0278241 Dictyostelium discoideum (Slime mold) TR41698_c0_g1_i6 P23193 TCEA1_HUMAN 1.00E-54 GO:0003677; GO:0030218; GO:0005730; GO:0005654; GO:0045944; GO:0050434; GO:0032784; GO:0006368; GO:0006283; GO:0016032; GO:0008270 Q8WVC0; Q8N7H5 "DNA binding; erythrocyte differentiation; nucleolus; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; positive regulation of viral transcription; regulation of DNA-dependent transcription, elongation; transcription elongation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair; viral process; zinc ion binding" IPR016492; IPR003617; IPR003618; IPR017923; IPR017890; IPR006289; IPR001222; Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) TCEA1 GTF2S TFIIS Homo sapiens (Human) TR41698_c0_g1_i7 P23193 TCEA1_HUMAN 1.00E-54 GO:0003677; GO:0030218; GO:0005730; GO:0005654; GO:0045944; GO:0050434; GO:0032784; GO:0006368; GO:0006283; GO:0016032; GO:0008270 Q8WVC0; Q8N7H5 "DNA binding; erythrocyte differentiation; nucleolus; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; positive regulation of viral transcription; regulation of DNA-dependent transcription, elongation; transcription elongation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair; viral process; zinc ion binding" IPR016492; IPR003617; IPR003618; IPR017923; IPR017890; IPR006289; IPR001222; Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) TCEA1 GTF2S TFIIS Homo sapiens (Human) TR41700_c3_g3_i3 B6NK32 U631_BRAFL 2.00E-21 IPR008011; LYR motif-containing protein 9 LYRM9 BRAFLDRAFT_231075 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR41700_c3_g6_i1 Q9NX57 RAB20_HUMAN 4.00E-34 GO:0005525; GO:0005794; GO:0045335; GO:0030670; GO:0090383; GO:0090385; GO:0015031; GO:0007264 GTP binding; Golgi apparatus; phagocytic vesicle; phagocytic vesicle membrane; phagosome acidification; phagosome-lysosome fusion; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; Ras-related protein Rab-20 RAB20 Homo sapiens (Human) TR41701_c0_g1_i1 P24733 MYS_AEQIR 2.00E-159 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR015650; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, striated muscle" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR41701_c0_g2_i2 P24733 MYS_AEQIR 5.00E-140 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR015650; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, striated muscle" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR41702_c1_g1_i12 Q8NHV1 GIMA7_HUMAN 6.00E-12 GO:0005525; GO:0003924; GO:0005811 GTP binding; GTPase activity; lipid particle IPR006703; IPR027417; GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) TR41702_c1_g1_i9 Q9NUV9 GIMA4_HUMAN 3.00E-40 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR41703_c0_g1_i1 P83662 ACMSD_PIG 4.00E-19 GO:0001760; GO:0005829; GO:0046872; GO:0046874 aminocarboxymuconate-semialdehyde decarboxylase activity; cytosol; metal ion binding; quinolinate metabolic process Secondary metabolite metabolism; quinolate metabolism. 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase) (Fragments) ACMSD Sus scrofa (Pig) TR41703_c0_g1_i10 Q8T8B9 ACMSD_CAEEL 8.00E-98 GO:0001760; GO:0005829; GO:0046872; GO:0046874 aminocarboxymuconate-semialdehyde decarboxylase activity; cytosol; metal ion binding; quinolinate metabolic process IPR006992; Secondary metabolite metabolism; quinolate metabolism. 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase) acmsd Y71D11A.3 Caenorhabditis elegans TR41703_c0_g1_i11 Q0II68 ACMSD_BOVIN 5.00E-155 GO:0001760; GO:0005829; GO:0046872; GO:0046874 aminocarboxymuconate-semialdehyde decarboxylase activity; cytosol; metal ion binding; quinolinate metabolic process IPR006992; Secondary metabolite metabolism; quinolate metabolism. 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase) ACMSD Bos taurus (Bovine) TR41703_c0_g1_i13 Q8T8B9 ACMSD_CAEEL 1.00E-97 GO:0001760; GO:0005829; GO:0046872; GO:0046874 aminocarboxymuconate-semialdehyde decarboxylase activity; cytosol; metal ion binding; quinolinate metabolic process IPR006992; Secondary metabolite metabolism; quinolate metabolism. 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase) acmsd Y71D11A.3 Caenorhabditis elegans TR41703_c0_g1_i14 Q0II68 ACMSD_BOVIN 5.00E-155 GO:0001760; GO:0005829; GO:0046872; GO:0046874 aminocarboxymuconate-semialdehyde decarboxylase activity; cytosol; metal ion binding; quinolinate metabolic process IPR006992; Secondary metabolite metabolism; quinolate metabolism. 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase) ACMSD Bos taurus (Bovine) TR41703_c0_g1_i2 Q8T8B9 ACMSD_CAEEL 8.00E-93 GO:0001760; GO:0005829; GO:0046872; GO:0046874 aminocarboxymuconate-semialdehyde decarboxylase activity; cytosol; metal ion binding; quinolinate metabolic process IPR006992; Secondary metabolite metabolism; quinolate metabolism. 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase) acmsd Y71D11A.3 Caenorhabditis elegans TR41703_c0_g1_i3 Q0II68 ACMSD_BOVIN 6.00E-153 GO:0001760; GO:0005829; GO:0046872; GO:0046874 aminocarboxymuconate-semialdehyde decarboxylase activity; cytosol; metal ion binding; quinolinate metabolic process IPR006992; Secondary metabolite metabolism; quinolate metabolism. 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase) ACMSD Bos taurus (Bovine) TR41703_c0_g1_i5 Q8T8B9 ACMSD_CAEEL 8.00E-93 GO:0001760; GO:0005829; GO:0046872; GO:0046874 aminocarboxymuconate-semialdehyde decarboxylase activity; cytosol; metal ion binding; quinolinate metabolic process IPR006992; Secondary metabolite metabolism; quinolate metabolism. 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase) acmsd Y71D11A.3 Caenorhabditis elegans TR41703_c0_g1_i8 Q0II68 ACMSD_BOVIN 7.00E-153 GO:0001760; GO:0005829; GO:0046872; GO:0046874 aminocarboxymuconate-semialdehyde decarboxylase activity; cytosol; metal ion binding; quinolinate metabolic process IPR006992; Secondary metabolite metabolism; quinolate metabolism. 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase) ACMSD Bos taurus (Bovine) TR41704_c0_g1_i1 Q5RDW9 CSTF3_PONAB 0 GO:0006397; GO:0005634 mRNA processing; nucleus IPR003107; IPR008847; Cleavage stimulation factor subunit 3 (CF-1 77 kDa subunit) (Cleavage stimulation factor 77 kDa subunit) (CSTF 77 kDa subunit) (CstF-77) CSTF3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41705_c1_g4_i2 P20749 BCL3_HUMAN 9.00E-15 GO:0032996; GO:0033257; GO:0003677; GO:0030330; GO:0007249; GO:0042088; GO:0045064; GO:0019730; GO:0005737; GO:0042742; GO:0042832; GO:0030198; GO:0002268; GO:0002467; GO:0002455; GO:0042771; GO:0051457; GO:0002315; GO:0043066; GO:0045415; GO:0045892; GO:0042536; GO:0005634; GO:0048471; GO:0032729; GO:0045082; GO:0045944; GO:0045893; GO:0045727; GO:0030674; GO:0000060; GO:0051101; GO:0042345; GO:0010225; GO:0009615; GO:0003700; GO:0048536; GO:0006351 O95999; P56545; P06239 "Bcl3-Bcl10 complex; Bcl3/NF-kappaB2 complex; DNA binding; DNA damage response, signal transduction by p53 class mediator; I-kappaB kinase/NF-kappaB cascade; T-helper 1 type immune response; T-helper 2 cell differentiation; antimicrobial humoral response; cytoplasm; defense response to bacterium; defense response to protozoan; extracellular matrix organization; follicular dendritic cell differentiation; germinal center formation; humoral immune response mediated by circulating immunoglobulin; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; maintenance of protein location in nucleus; marginal zone B cell differentiation; negative regulation of apoptotic process; negative regulation of interleukin-8 biosynthetic process; negative regulation of transcription, DNA-dependent; negative regulation of tumor necrosis factor biosynthetic process; nucleus; perinuclear region of cytoplasm; positive regulation of interferon-gamma production; positive regulation of interleukin-10 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of translation; protein binding, bridging; protein import into nucleus, translocation; regulation of DNA binding; regulation of NF-kappaB import into nucleus; response to UV-C; response to virus; sequence-specific DNA binding transcription factor activity; spleen development; transcription, DNA-dependent" IPR002110; IPR020683; B-cell lymphoma 3 protein (BCL-3) (Proto-oncogene BCL3) BCL3 BCL4 D19S37 Homo sapiens (Human) TR41706_c2_g1_i1 A8E7I5 TTC36_DANRE 8.00E-59 IPR013026; IPR011990; IPR013105; IPR019734; Tetratricopeptide repeat protein 36 (TPR repeat protein 36) ttc36 si:rp71-52f21.2 zgc:103600 Danio rerio (Zebrafish) (Brachydanio rerio) TR41709_c0_g1_i10 Q53G44 IF44L_HUMAN 2.00E-37 GO:0005737; GO:0051607; GO:0006955 cytoplasm; defense response to virus; immune response IPR024644; IPR027417; Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) TR41709_c0_g1_i6 Q53G44 IF44L_HUMAN 2.00E-37 GO:0005737; GO:0051607; GO:0006955 cytoplasm; defense response to virus; immune response IPR024644; IPR027417; Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) TR41711_c4_g1_i4 O01393 UNC9_CAEEL 2.00E-83 GO:0005921; GO:0055077; GO:0016021; GO:0034220; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transmembrane transport; plasma membrane IPR000990; Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans TR41712_c0_g2_i2 Q9RUW8 RO60_DEIRA 1.00E-25 GO:0003723; GO:0005737; GO:0046872; GO:0030529 RNA binding; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein homolog (Ro sixty-related protein) rsr DR_1262 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) TR41712_c0_g2_i4 P42700 RO60_XENLA 7.00E-64 GO:0003723; GO:0030030; GO:0005737; GO:0046872; GO:0030529 RNA binding; cell projection organization; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) trove2 Xenopus laevis (African clawed frog) TR41713_c4_g1_i4 Q14146 URB2_HUMAN 5.00E-13 GO:0005730 nucleolus IPR018849; Unhealthy ribosome biogenesis protein 2 homolog URB2 KIAA0133 Homo sapiens (Human) TR41714_c1_g4_i1 Q62172 RBP1_MOUSE 9.00E-68 GO:0043492; GO:0030675; GO:0005622; GO:0016020; GO:0043089; GO:0007264; GO:0006810 "ATPase activity, coupled to movement of substances; Rac GTPase activator activity; intracellular; membrane; positive regulation of Cdc42 GTPase activity; small GTPase mediated signal transduction; transport" IPR008936; IPR000198; RalA-binding protein 1 (RalBP1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (Ral-interacting protein 1) Ralbp1 Rip1 Mus musculus (Mouse) TR41715_c0_g1_i2 Q95218 DMBT1_RABIT 2.00E-39 GO:0030154; GO:0005576; GO:0019898; GO:0007275; GO:0015031; GO:0005044; GO:0035375; GO:0042589 cell differentiation; extracellular region; extrinsic to membrane; multicellular organismal development; protein transport; scavenger receptor activity; zymogen binding; zymogen granule membrane IPR000859; IPR001190; IPR017448; IPR001507; IPR017977; Deleted in malignant brain tumors 1 protein (Hensin) Dmbt1 Oryctolagus cuniculus (Rabbit) TR41715_c0_g1_i3 Q2VLH6 C163A_MOUSE 9.00E-44 GO:0006953; GO:0005576; GO:0016021; GO:0005886; GO:0005044 acute-phase response; extracellular region; integral to membrane; plasma membrane; scavenger receptor activity IPR001190; IPR017448; Scavenger receptor cysteine-rich type 1 protein M130 (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)] Cd163 M130 Mus musculus (Mouse) TR41715_c0_g1_i4 Q5G267 NETR_MACMU 1.00E-36 GO:0030424; GO:0006887; GO:0005576; GO:0005886; GO:0006508; GO:0005044; GO:0004252 axon; exocytosis; extracellular region; plasma membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR001190; IPR017448; IPR009003; Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Macaca mulatta (Rhesus macaque) TR41715_c0_g1_i7 P58215 LOXL3_HUMAN 4.00E-21 GO:0005507; GO:0001837; GO:0005576; GO:0005615; GO:0016020; GO:0045892; GO:0005634; GO:0004720; GO:0005044 "copper ion binding; epithelial to mesenchymal transition; extracellular region; extracellular space; membrane; negative regulation of transcription, DNA-dependent; nucleus; protein-lysine 6-oxidase activity; scavenger receptor activity" IPR001695; IPR019828; IPR001190; IPR017448; Lysyl oxidase homolog 3 (EC 1.4.3.-) (Lysyl oxidase-like protein 3) LOXL3 LOXL Homo sapiens (Human) TR41715_c0_g1_i9 Q2VLH6 C163A_MOUSE 2.00E-45 GO:0006953; GO:0005576; GO:0016021; GO:0005886; GO:0005044 acute-phase response; extracellular region; integral to membrane; plasma membrane; scavenger receptor activity IPR001190; IPR017448; Scavenger receptor cysteine-rich type 1 protein M130 (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)] Cd163 M130 Mus musculus (Mouse) TR41716_c1_g3_i1 Q6NT16 S18B1_HUMAN 1.00E-65 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR020846; IPR016196; MFS-type transporter SLC18B1 (Solute carrier family 18 member B1) SLC18B1 C6orf192 Homo sapiens (Human) TR41716_c1_g3_i2 D3Z5L6 S18B1_MOUSE 2.00E-66 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR020846; IPR016196; MFS-type transporter SLC18B1 (Solute carrier family 18 member B1) Slc18b1 Mus musculus (Mouse) TR41716_c1_g3_i6 D3Z5L6 S18B1_MOUSE 3.00E-67 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR020846; IPR016196; MFS-type transporter SLC18B1 (Solute carrier family 18 member B1) Slc18b1 Mus musculus (Mouse) TR41719_c0_g3_i1 Q9UHY8 FEZ2_HUMAN 4.00E-44 GO:0007411; GO:0007165 Q96PY6 axon guidance; signal transduction IPR011680; IPR015641; Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2) FEZ2 Homo sapiens (Human) TR41720_c2_g1_i1 Q6PAV2 HERC4_MOUSE 1.00E-09 GO:0030154; GO:0005737; GO:0005829; GO:0005634; GO:0042787; GO:0007283; GO:0004842 cell differentiation; cytoplasm; cytosol; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; spermatogenesis; ubiquitin-protein ligase activity IPR000569; IPR009091; IPR000408; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HERC4 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 4) Herc4 Mus musculus (Mouse) TR41720_c3_g1_i1 Q9P2D0 IBTK_HUMAN 4.00E-104 GO:0005737; GO:0016020; GO:0005634; GO:0019901; GO:0030292; GO:0051209 cytoplasm; membrane; nucleus; protein kinase binding; protein tyrosine kinase inhibitor activity; release of sequestered calcium ion into cytosol IPR002110; IPR020683; IPR000210; IPR011333; IPR013069; IPR009091; IPR000408; Inhibitor of Bruton tyrosine kinase (IBtk) IBTK BTKI KIAA1417 Homo sapiens (Human) TR41720_c3_g1_i11 Q9P2D0 IBTK_HUMAN 4.00E-104 GO:0005737; GO:0016020; GO:0005634; GO:0019901; GO:0030292; GO:0051209 cytoplasm; membrane; nucleus; protein kinase binding; protein tyrosine kinase inhibitor activity; release of sequestered calcium ion into cytosol IPR002110; IPR020683; IPR000210; IPR011333; IPR013069; IPR009091; IPR000408; Inhibitor of Bruton tyrosine kinase (IBtk) IBTK BTKI KIAA1417 Homo sapiens (Human) TR41720_c3_g1_i2 Q9P2D0 IBTK_HUMAN 4.00E-104 GO:0005737; GO:0016020; GO:0005634; GO:0019901; GO:0030292; GO:0051209 cytoplasm; membrane; nucleus; protein kinase binding; protein tyrosine kinase inhibitor activity; release of sequestered calcium ion into cytosol IPR002110; IPR020683; IPR000210; IPR011333; IPR013069; IPR009091; IPR000408; Inhibitor of Bruton tyrosine kinase (IBtk) IBTK BTKI KIAA1417 Homo sapiens (Human) TR41720_c3_g1_i4 B7U179 ABAP1_ARATH 1.00E-10 GO:0031261; GO:0006261; GO:2000104; GO:0008285; GO:0016567 Q9SU24; Q9SJW9; Q9M1S9; Q710E8; Q9C758 DNA replication preinitiation complex; DNA-dependent DNA replication; negative regulation of DNA-dependent DNA replication; negative regulation of cell proliferation; protein ubiquitination IPR011989; IPR016024; IPR000225; IPR000210; IPR011333; IPR013069; Protein modification; protein ubiquitination. ARMADILLO BTB ARABIDOPSIS PROTEIN 1 (ABAP1) ABAP1 At5g13060 T19L5.20 Arabidopsis thaliana (Mouse-ear cress) TR41720_c3_g1_i5 Q6ZPR6 IBTK_MOUSE 3.00E-98 GO:0005737; GO:0016020; GO:0005634; GO:0030292; GO:0051209 cytoplasm; membrane; nucleus; protein tyrosine kinase inhibitor activity; release of sequestered calcium ion into cytosol IPR002110; IPR020683; IPR000210; IPR011333; IPR013069; IPR009091; IPR000408; Inhibitor of Bruton tyrosine kinase (IBtk) Ibtk Kiaa1417 Mus musculus (Mouse) TR41720_c3_g1_i6 Q9P2D0 IBTK_HUMAN 7.00E-105 GO:0005737; GO:0016020; GO:0005634; GO:0019901; GO:0030292; GO:0051209 cytoplasm; membrane; nucleus; protein kinase binding; protein tyrosine kinase inhibitor activity; release of sequestered calcium ion into cytosol IPR002110; IPR020683; IPR000210; IPR011333; IPR013069; IPR009091; IPR000408; Inhibitor of Bruton tyrosine kinase (IBtk) IBTK BTKI KIAA1417 Homo sapiens (Human) TR41720_c3_g1_i9 Q9P2D0 IBTK_HUMAN 1.00E-104 GO:0005737; GO:0016020; GO:0005634; GO:0019901; GO:0030292; GO:0051209 cytoplasm; membrane; nucleus; protein kinase binding; protein tyrosine kinase inhibitor activity; release of sequestered calcium ion into cytosol IPR002110; IPR020683; IPR000210; IPR011333; IPR013069; IPR009091; IPR000408; Inhibitor of Bruton tyrosine kinase (IBtk) IBTK BTKI KIAA1417 Homo sapiens (Human) TR41721_c0_g2_i1 Q6NXA9 UBXN1_DANRE 2.00E-08 GO:0071796; GO:0005737; GO:0032435; GO:0031397 K6-linked polyubiquitin binding; cytoplasm; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein ubiquitination IPR009060; IPR015940; IPR000449; IPR001012; UBX domain-containing protein 1 (SAPK substrate protein 1) ubxn1 saks1 zgc:77531 Danio rerio (Zebrafish) (Brachydanio rerio) TR41721_c0_g3_i1 P54201 UBPA_DICDI 0 GO:0008234; GO:0008242; GO:0004221; GO:0006511; GO:0008270 cysteine-type peptidase activity; omega peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; zinc ion binding IPR018200; IPR001394; IPR009060; IPR015940; IPR000449; IPR016652; IPR013083; IPR001607; Ubiquitin carboxyl-terminal hydrolase A (EC 3.4.19.12) (Deubiquitinating enzyme A) (Ubiquitin thioesterase A) (Ubiquitin-specific-processing protease A) ubpA usp5 DDB_G0291239 Dictyostelium discoideum (Slime mold) TR41721_c0_g3_i3 P56399 UBP5_MOUSE 0 GO:0008234; GO:0008242; GO:0032436; GO:0071108; GO:0004221; GO:0006511; GO:0008270 cysteine-type peptidase activity; omega peptidase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein K48-linked deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; zinc ion binding IPR018200; IPR001394; IPR009060; IPR015940; IPR000449; IPR016652; IPR013083; IPR001607; Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) Usp5 Isot Mus musculus (Mouse) TR41723_c0_g1_i2 Q7Z5K2 WAPL_HUMAN 5.00E-119 GO:0051301; GO:0000785; GO:0000775; GO:0008278; GO:0005829; GO:0015630; GO:0007067; GO:0000278; GO:0019048; GO:0008156; GO:0035562; GO:0045875; GO:0005654; GO:0071168; GO:0071922; GO:0009636; GO:0000795 Q9NTI5; O60216 "cell division; chromatin; chromosome, centromeric region; cohesin complex; cytosol; microtubule cytoskeleton; mitosis; mitotic cell cycle; modulation by virus of host morphology or physiology; negative regulation of DNA replication; negative regulation of chromatin binding; negative regulation of sister chromatid cohesion; nucleoplasm; protein localization to chromatin; regulation of cohesin localization to chromatin; response to toxic substance; synaptonemal complex" IPR016024; IPR012502; IPR022771; Wings apart-like protein homolog (Friend of EBNA2 protein) WAPAL FOE KIAA0261 WAPL Homo sapiens (Human) TR41723_c0_g1_i4 Q7Z5K2 WAPL_HUMAN 4.00E-127 GO:0051301; GO:0000785; GO:0000775; GO:0008278; GO:0005829; GO:0015630; GO:0007067; GO:0000278; GO:0019048; GO:0008156; GO:0035562; GO:0045875; GO:0005654; GO:0071168; GO:0071922; GO:0009636; GO:0000795 Q9NTI5; O60216 "cell division; chromatin; chromosome, centromeric region; cohesin complex; cytosol; microtubule cytoskeleton; mitosis; mitotic cell cycle; modulation by virus of host morphology or physiology; negative regulation of DNA replication; negative regulation of chromatin binding; negative regulation of sister chromatid cohesion; nucleoplasm; protein localization to chromatin; regulation of cohesin localization to chromatin; response to toxic substance; synaptonemal complex" IPR016024; IPR012502; IPR022771; Wings apart-like protein homolog (Friend of EBNA2 protein) WAPAL FOE KIAA0261 WAPL Homo sapiens (Human) TR41724_c0_g1_i1 Q9P2Q2 FRM4A_HUMAN 4.00E-135 GO:0005737; GO:0005856; GO:0090162; GO:0005923 cytoplasm; cytoskeleton; establishment of epithelial cell polarity; tight junction IPR019749; IPR019750; IPR021774; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; FERM domain-containing protein 4A FRMD4A FRMD4 KIAA1294 Homo sapiens (Human) TR41724_c0_g1_i3 Q9P2Q2 FRM4A_HUMAN 0 GO:0005737; GO:0005856; GO:0090162; GO:0005923 cytoplasm; cytoskeleton; establishment of epithelial cell polarity; tight junction IPR019749; IPR019750; IPR021774; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; FERM domain-containing protein 4A FRMD4A FRMD4 KIAA1294 Homo sapiens (Human) TR41724_c0_g1_i4 Q3KP66 CA106_HUMAN 3.00E-19 IPR021774; Uncharacterized protein C1orf106 C1orf106 Homo sapiens (Human) TR41724_c0_g1_i5 A2AD83 FRMD7_MOUSE 4.00E-10 GO:0005856; GO:0030426; GO:0043025; GO:0010975 cytoskeleton; growth cone; neuronal cell body; regulation of neuron projection development IPR019749; IPR019750; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; FERM domain-containing protein 7 Frmd7 Mus musculus (Mouse) TR41724_c0_g1_i6 Q9P2Q2 FRM4A_HUMAN 2.00E-145 GO:0005737; GO:0005856; GO:0090162; GO:0005923 cytoplasm; cytoskeleton; establishment of epithelial cell polarity; tight junction IPR019749; IPR019750; IPR021774; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; FERM domain-containing protein 4A FRMD4A FRMD4 KIAA1294 Homo sapiens (Human) TR41726_c0_g1_i1 Q803T2 FA40A_DANRE 0 GO:0030866; GO:0005737; GO:0022604 cortical actin cytoskeleton organization; cytoplasm; regulation of cell morphogenesis IPR021819; IPR012486; Striatin-interacting protein 1 homolog strip1 fam40a Danio rerio (Zebrafish) (Brachydanio rerio) TR41726_c0_g1_i2 Q54IL2 FAM40_DICDI 1.00E-11 IPR021819; IPR012486; Striatin-interacting protein homolog fam40 DDB_G0288685 Dictyostelium discoideum (Slime mold) TR41726_c0_g2_i5 Q803T2 FA40A_DANRE 1.00E-27 GO:0030866; GO:0005737; GO:0022604 cortical actin cytoskeleton organization; cytoplasm; regulation of cell morphogenesis IPR021819; IPR012486; Striatin-interacting protein 1 homolog strip1 fam40a Danio rerio (Zebrafish) (Brachydanio rerio) TR41727_c0_g1_i1 A4IGL7 PXDN_XENTR 0 GO:0005576; GO:0020037; GO:0042744; GO:0046872; GO:0004601 extracellular region; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; IPR001007; Peroxidasin (EC 1.11.1.7) pxdn pxn Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41727_c0_g1_i3 A4IGL7 PXDN_XENTR 0 GO:0005576; GO:0020037; GO:0042744; GO:0046872; GO:0004601 extracellular region; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; IPR001007; Peroxidasin (EC 1.11.1.7) pxdn pxn Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41727_c0_g1_i4 P35419 PERT_MOUSE 3.00E-101 GO:0005509; GO:0035162; GO:0020037; GO:0042446; GO:0042744; GO:0016021; GO:0004447; GO:0005739; GO:0006590 calcium ion binding; embryonic hemopoiesis; heme binding; hormone biosynthetic process; hydrogen peroxide catabolic process; integral to membrane; iodide peroxidase activity; mitochondrion; thyroid hormone generation IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR010255; IPR002007; IPR019791; IPR000436; Hormone biosynthesis; thyroid hormone biosynthesis. Thyroid peroxidase (TPO) (EC 1.11.1.8) Tpo Mus musculus (Mouse) TR41727_c0_g1_i5 A4IGL7 PXDN_XENTR 0 GO:0005576; GO:0020037; GO:0042744; GO:0046872; GO:0004601 extracellular region; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; IPR001007; Peroxidasin (EC 1.11.1.7) pxdn pxn Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41727_c0_g1_i7 O95970 LGI1_HUMAN 3.00E-18 GO:0007411; GO:0030054; GO:0008283; GO:0005576; GO:0005615; GO:0030307; GO:0050806; GO:0051260; GO:0045202 axon guidance; cell junction; cell proliferation; extracellular region; extracellular space; positive regulation of cell growth; positive regulation of synaptic transmission; protein homooligomerization; synapse IPR000483; IPR009039; IPR005492; IPR003591; IPR000372; Leucine-rich glioma-inactivated protein 1 (Epitempin-1) LGI1 EPT UNQ775/PRO1569 Homo sapiens (Human) TR41727_c0_g1_i8 A4IGL7 PXDN_XENTR 0 GO:0005576; GO:0020037; GO:0042744; GO:0046872; GO:0004601 extracellular region; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; IPR001007; Peroxidasin (EC 1.11.1.7) pxdn pxn Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41727_c0_g1_i9 O89026 ROBO1_MOUSE 6.00E-41 GO:0030673; GO:0016199; GO:0016021; GO:0060763; GO:0008285; GO:0021891 axolemma; axon midline choice point recognition; integral to membrane; mammary duct terminal end bud growth; negative regulation of cell proliferation; olfactory bulb interneuron development IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR003596; Roundabout homolog 1 Robo1 Dutt1 Mus musculus (Mouse) TR41728_c1_g1_i1 A1ZA47 ZASP_DROME 3.00E-22 GO:0030018; GO:0015629; GO:0051371; GO:0005927; GO:0030239; GO:0001952; GO:0008270 Z disc; actin cytoskeleton; muscle alpha-actinin binding; muscle tendon junction; myofibril assembly; regulation of cell-matrix adhesion; zinc ion binding IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) TR41728_c2_g1_i2 A1ZBT5 MED8_DROME 4.00E-56 GO:0001104; GO:0016592; GO:0051726; GO:0006367 RNA polymerase II transcription cofactor activity; mediator complex; regulation of cell cycle; transcription initiation from RNA polymerase II promoter IPR019364; Mediator of RNA polymerase II transcription subunit 8 (Mediator complex subunit 8) MED8 Arc32 CG13867 Drosophila melanogaster (Fruit fly) TR41728_c2_g1_i3 Q08BU1 MED8_XENTR 5.00E-70 GO:0001104; GO:0016592; GO:0016567 RNA polymerase II transcription cofactor activity; mediator complex; protein ubiquitination IPR019364; Protein modification; protein ubiquitination. Mediator of RNA polymerase II transcription subunit 8 (Mediator complex subunit 8) med8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41728_c2_g1_i5 Q6NYT1 MED8_DANRE 1.00E-61 GO:0001104; GO:0016592; GO:0016567 RNA polymerase II transcription cofactor activity; mediator complex; protein ubiquitination IPR019364; Protein modification; protein ubiquitination. Mediator of RNA polymerase II transcription subunit 8 (Mediator complex subunit 8) med8 zgc:76877 Danio rerio (Zebrafish) (Brachydanio rerio) TR41728_c3_g1_i1 Q5SSZ5 TENS3_MOUSE 2.00E-107 GO:0016477; GO:0005925; GO:0048286; GO:0008284 cell migration; focal adhesion; lung alveolus development; positive regulation of cell proliferation IPR000008; IPR011993; IPR014019; IPR013625; IPR006020; IPR000980; IPR014020; Tensin-3 (Tensin-like SH2 domain-containing protein 1) Tns3 Tens1 Mus musculus (Mouse) TR41728_c3_g1_i3 Q5SSZ5 TENS3_MOUSE 2.00E-107 GO:0016477; GO:0005925; GO:0048286; GO:0008284 cell migration; focal adhesion; lung alveolus development; positive regulation of cell proliferation IPR000008; IPR011993; IPR014019; IPR013625; IPR006020; IPR000980; IPR014020; Tensin-3 (Tensin-like SH2 domain-containing protein 1) Tns3 Tens1 Mus musculus (Mouse) TR41729_c4_g1_i1 Q69ZU6 THS7A_MOUSE 5.00E-28 GO:0001525; GO:0030154; GO:0005576; GO:0016021; GO:0005886 angiogenesis; cell differentiation; extracellular region; integral to membrane; plasma membrane IPR000884; Thrombospondin type-1 domain-containing protein 7A Thsd7a Gm837 Kiaa0960 Mus musculus (Mouse) TR41729_c4_g1_i2 Q6P4U0 THS7B_MOUSE 1.00E-25 GO:0016021 integral to membrane IPR000884; Thrombospondin type-1 domain-containing protein 7B Thsd7b Mus musculus (Mouse) TR41729_c4_g1_i3 O95428 PPN_HUMAN 2.00E-09 GO:0005604; GO:0004222; GO:0004867; GO:0008270 basement membrane; metalloendopeptidase activity; serine-type endopeptidase inhibitor activity; zinc ion binding IPR010294; IPR007110; IPR013783; IPR013098; IPR003598; IPR013273; IPR010909; IPR002223; IPR020901; IPR000884; Papilin PAPLN UNQ2420/PRO4977 Homo sapiens (Human) TR41729_c4_g1_i5 Q9EPX2 PPN_MOUSE 6.00E-08 GO:0005604; GO:0004222; GO:0004867; GO:0008270 basement membrane; metalloendopeptidase activity; serine-type endopeptidase inhibitor activity; zinc ion binding IPR010294; IPR007110; IPR013783; IPR013098; IPR003598; IPR013106; IPR013273; IPR010909; IPR002223; IPR020901; IPR000884; Papilin Papln Mus musculus (Mouse) TR41729_c4_g2_i2 Q9C0I4 THS7B_HUMAN 1.00E-178 GO:0016021 integral to membrane IPR000884; Thrombospondin type-1 domain-containing protein 7B THSD7B KIAA1679 Homo sapiens (Human) TR41729_c4_g2_i3 Q6P4U0 THS7B_MOUSE 0 GO:0016021 integral to membrane IPR000884; Thrombospondin type-1 domain-containing protein 7B Thsd7b Mus musculus (Mouse) TR41730_c0_g1_i3 Q920Q2 REV1_MOUSE 5.00E-55 GO:0006260; GO:0003887; GO:0003684; GO:0017125; GO:0042276; GO:0000287; GO:0005634; GO:0009411 DNA replication; DNA-directed DNA polymerase activity; damaged DNA binding; deoxycytidyl transferase activity; error-prone translesion synthesis; magnesium ion binding; nucleus; response to UV IPR001357; IPR017961; IPR001126; IPR017963; IPR012112; DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase) Rev1 Rev1l Mus musculus (Mouse) TR41730_c0_g3_i1 Q2A3L2 DPO4_FRATH 2.00E-10 GO:0006281; GO:0006261; GO:0003887; GO:0005737; GO:0003684; GO:0000287 DNA repair; DNA-dependent DNA replication; DNA-directed DNA polymerase activity; cytoplasm; damaged DNA binding; magnesium ion binding IPR017961; IPR001126; IPR017963; IPR022880; IPR024728; DNA polymerase IV (Pol IV) (EC 2.7.7.7) dinB FTL_0981 Francisella tularensis subsp. holarctica (strain LVS) TR41730_c0_g4_i1 Q9CNG4 DPO4_PASMU 7.00E-10 GO:0006281; GO:0006261; GO:0003887; GO:0005737; GO:0003684; GO:0000287 DNA repair; DNA-dependent DNA replication; DNA-directed DNA polymerase activity; cytoplasm; damaged DNA binding; magnesium ion binding IPR017961; IPR001126; IPR017963; IPR022880; IPR003583; IPR024728; DNA polymerase IV (Pol IV) (EC 2.7.7.7) dinB PM0467 Pasteurella multocida (strain Pm70) TR41731_c0_g1_i1 Q5T0N1 TTC18_HUMAN 5.00E-163 IPR013026; IPR011990; IPR019734; Tetratricopeptide repeat protein 18 (TPR repeat protein 18) TTC18 Homo sapiens (Human) TR41731_c0_g1_i3 Q95LN2 TTC18_MACFA 2.00E-135 IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 18 (TPR repeat protein 18) TTC18 QtsA-14176 QtsA-14782 QtsA-18431 QtsA-18615 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR41731_c0_g1_i5 Q5T0N1 TTC18_HUMAN 2.00E-137 IPR013026; IPR011990; IPR019734; Tetratricopeptide repeat protein 18 (TPR repeat protein 18) TTC18 Homo sapiens (Human) TR41732_c2_g1_i1 Q9VJE5 CL190_DROME 2.00E-12 GO:0005794; GO:0003779; GO:0007349; GO:0045169; GO:0000776; GO:0005875; GO:0051010; GO:0007017; GO:0005876 Golgi apparatus; actin binding; cellularization; fusome; kinetochore; microtubule associated complex; microtubule plus-end binding; microtubule-based process; spindle microtubule IPR000938; Restin homolog (Cytoplasmic linker protein 190) (Microtubule-binding protein 190) (d-CLIP-190) CLIP-190 CG5020 Drosophila melanogaster (Fruit fly) TR41732_c3_g1_i1 Q14203 DCTN1_HUMAN 1.00E-58 GO:0000086; GO:0006987; GO:0019886; GO:0008219; GO:0031252; GO:0044267; GO:0005813; GO:0005829; GO:0005869; GO:0030286; GO:0000776; GO:0005874; GO:0010970; GO:0007067; GO:0003774; GO:0007399; GO:0000922 Q96RK4; P10636-8 G2/M transition of mitotic cell cycle; activation of signaling protein activity involved in unfolded protein response; antigen processing and presentation of exogenous peptide antigen via MHC class II; cell death; cell leading edge; cellular protein metabolic process; centrosome; cytosol; dynactin complex; dynein complex; kinetochore; microtubule; microtubule-based transport; mitosis; motor activity; nervous system development; spindle pole IPR000938; IPR027663; IPR022157; Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) DCTN1 Homo sapiens (Human) TR41732_c3_g1_i8 Q14203 DCTN1_HUMAN 1.00E-61 GO:0000086; GO:0006987; GO:0019886; GO:0008219; GO:0031252; GO:0044267; GO:0005813; GO:0005829; GO:0005869; GO:0030286; GO:0000776; GO:0005874; GO:0010970; GO:0007067; GO:0003774; GO:0007399; GO:0000922 Q96RK4; P10636-8 G2/M transition of mitotic cell cycle; activation of signaling protein activity involved in unfolded protein response; antigen processing and presentation of exogenous peptide antigen via MHC class II; cell death; cell leading edge; cellular protein metabolic process; centrosome; cytosol; dynactin complex; dynein complex; kinetochore; microtubule; microtubule-based transport; mitosis; motor activity; nervous system development; spindle pole IPR000938; IPR027663; IPR022157; Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) DCTN1 Homo sapiens (Human) TR41732_c3_g2_i2 Q14203 DCTN1_HUMAN 2.00E-153 GO:0000086; GO:0006987; GO:0019886; GO:0008219; GO:0031252; GO:0044267; GO:0005813; GO:0005829; GO:0005869; GO:0030286; GO:0000776; GO:0005874; GO:0010970; GO:0007067; GO:0003774; GO:0007399; GO:0000922 Q96RK4; P10636-8 G2/M transition of mitotic cell cycle; activation of signaling protein activity involved in unfolded protein response; antigen processing and presentation of exogenous peptide antigen via MHC class II; cell death; cell leading edge; cellular protein metabolic process; centrosome; cytosol; dynactin complex; dynein complex; kinetochore; microtubule; microtubule-based transport; mitosis; motor activity; nervous system development; spindle pole IPR000938; IPR027663; IPR022157; Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) DCTN1 Homo sapiens (Human) TR41732_c3_g2_i4 P35458 DCTN1_CHICK 9.00E-82 GO:0005737; GO:0005869; GO:0030286; GO:0005874; GO:0010970; GO:0003774 cytoplasm; dynactin complex; dynein complex; microtubule; microtubule-based transport; motor activity IPR000938; IPR027663; IPR022157; Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p150-glued) DCTN1 Gallus gallus (Chicken) TR41733_c0_g3_i1 Q8N187 AL2S8_HUMAN 7.00E-102 GO:0003677; GO:0035865; GO:0005730; GO:0005654; GO:0005634; GO:0061400; GO:0003700; GO:0006351 "DNA binding; cellular response to potassium ion; nucleolus; nucleoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter in response to calcium ion; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" Calcium-responsive transcription factor (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) (Calcium-response factor) (CaRF) (Testis development protein NYD-SP24) CARF ALS2CR8 Homo sapiens (Human) TR41734_c0_g1_i1 Q6ZMP0 THSD4_HUMAN 2.00E-66 GO:0048251; GO:0004222; GO:0001527 elastic fiber assembly; metalloendopeptidase activity; microfibril IPR010294; IPR010909; IPR000884; Thrombospondin type-1 domain-containing protein 4 (A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6) (ADAMTS-like protein 6) (ADAMTSL-6) THSD4 UNQ9334/PRO34005 Homo sapiens (Human) TR41734_c0_g1_i2 Q769J6 ATS13_MOUSE 2.00E-20 GO:0007596; GO:0004175; GO:0005615; GO:0004222; GO:0043171; GO:0005578; GO:0006508; GO:0008270 blood coagulation; endopeptidase activity; extracellular space; metalloendopeptidase activity; peptide catabolic process; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR000859; IPR024079; IPR001590; IPR013273; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAM-TS 13) (ADAM-TS13) (ADAMTS-13) (EC 3.4.24.87) (von Willebrand factor-cleaving protease) (vWF-CP) (vWF-cleaving protease) Adamts13 Gm710 Mus musculus (Mouse) TR41734_c0_g1_i3 Q9EPX2 PPN_MOUSE 8.00E-52 GO:0005604; GO:0004222; GO:0004867; GO:0008270 basement membrane; metalloendopeptidase activity; serine-type endopeptidase inhibitor activity; zinc ion binding IPR010294; IPR007110; IPR013783; IPR013098; IPR003598; IPR013106; IPR013273; IPR010909; IPR002223; IPR020901; IPR000884; Papilin Papln Mus musculus (Mouse) TR41734_c0_g1_i4 Q6ZMP0 THSD4_HUMAN 3.00E-66 GO:0048251; GO:0004222; GO:0001527 elastic fiber assembly; metalloendopeptidase activity; microfibril IPR010294; IPR010909; IPR000884; Thrombospondin type-1 domain-containing protein 4 (A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6) (ADAMTS-like protein 6) (ADAMTSL-6) THSD4 UNQ9334/PRO34005 Homo sapiens (Human) TR41736_c0_g1_i1 Q9Y2E4 DIP2C_HUMAN 0 GO:0003824; GO:0005634 catalytic activity; nucleus IPR000873; IPR010506; Disco-interacting protein 2 homolog C (DIP2 homolog C) DIP2C KIAA0934 Homo sapiens (Human) TR41736_c0_g1_i2 Q9Y2E4 DIP2C_HUMAN 0 GO:0003824; GO:0005634 catalytic activity; nucleus IPR000873; IPR010506; Disco-interacting protein 2 homolog C (DIP2 homolog C) DIP2C KIAA0934 Homo sapiens (Human) TR41736_c0_g1_i3 Q9P265 DIP2B_HUMAN 0 GO:0003824; GO:0005634 catalytic activity; nucleus IPR000873; IPR010506; Disco-interacting protein 2 homolog B (DIP2 homolog B) DIP2B KIAA1463 Homo sapiens (Human) TR41736_c0_g1_i4 Q9Y2E4 DIP2C_HUMAN 0 GO:0003824; GO:0005634 catalytic activity; nucleus IPR000873; IPR010506; Disco-interacting protein 2 homolog C (DIP2 homolog C) DIP2C KIAA0934 Homo sapiens (Human) TR41737_c0_g4_i1 Q17770 PDI2_CAEEL 2.00E-29 GO:0045454; GO:0005783; GO:0005788; GO:0006662; GO:0055114; GO:0018401; GO:0080058; GO:0003756; GO:0015035; GO:0003810 cell redox homeostasis; endoplasmic reticulum; endoplasmic reticulum lumen; glycerol ether metabolic process; oxidation-reduction process; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; protein deglutathionylation; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; protein-glutamine gamma-glutamyltransferase activity IPR005788; IPR005792; IPR005746; IPR012336; IPR017937; IPR013766; Protein disulfide-isomerase 2 (EC 5.3.4.1) (PDI 1) (Prolyl 4-hydroxylase subunit beta-2) pdi-2 C07A12.4 Caenorhabditis elegans TR41737_c0_g4_i3 Q63081 PDIA6_RAT 2.00E-174 GO:0005509; GO:0045454; GO:0005788; GO:0005793; GO:0006662; GO:0042470; GO:0005886; GO:0070527; GO:0003756; GO:0015035; GO:0005790 calcium ion binding; cell redox homeostasis; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment; glycerol ether metabolic process; melanosome; plasma membrane; platelet aggregation; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; smooth endoplasmic reticulum IPR005788; IPR005746; IPR012336; IPR017937; IPR013766; Protein disulfide-isomerase A6 (EC 5.3.4.1) (Calcium-binding protein 1) (CaBP1) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) Pdia6 Cabp1 Txndc7 Rattus norvegicus (Rat) TR41737_c0_g4_i4 Q11067 PDIA6_CAEEL 1.00E-171 GO:0045454; GO:0005788; GO:0006662; GO:0003756; GO:0015035; GO:0006457 cell redox homeostasis; endoplasmic reticulum lumen; glycerol ether metabolic process; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; protein folding IPR005788; IPR005746; IPR012336; IPR017937; IPR013766; Probable protein disulfide-isomerase A6 (EC 5.3.4.1) tag-320 B0403.4 Caenorhabditis elegans TR41737_c0_g4_i5 Q11067 PDIA6_CAEEL 2.00E-70 GO:0045454; GO:0005788; GO:0006662; GO:0003756; GO:0015035; GO:0006457 cell redox homeostasis; endoplasmic reticulum lumen; glycerol ether metabolic process; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; protein folding IPR005788; IPR005746; IPR012336; IPR017937; IPR013766; Probable protein disulfide-isomerase A6 (EC 5.3.4.1) tag-320 B0403.4 Caenorhabditis elegans TR41739_c1_g2_i1 Q96C45 ULK4_HUMAN 4.00E-07 GO:0005524; GO:0060271; GO:0003351; GO:0004674; GO:0021591 ATP binding; cilium morphogenesis; epithelial cilium movement; protein serine/threonine kinase activity; ventricular system development IPR011989; IPR016024; IPR011009; IPR000719; Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4) ULK4 Homo sapiens (Human) TR41739_c1_g2_i12 P21901 KAPL_APLCA 3.00E-91 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR000961; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Spermatozoon-associated protein kinase (SAK) (EC 2.7.11.1) (C-APL-B) Aplysia californica (California sea hare) TR41739_c1_g2_i13 P12370 KAPC_DROME 0 GO:0005524; GO:0007615; GO:0007448; GO:0048149; GO:0004691; GO:0005952; GO:0019933; GO:0048749; GO:0007480; GO:0007476; GO:0045475; GO:0045879; GO:0008355; GO:0007314; GO:0008103; GO:0005886; GO:0007228; GO:0008359; GO:0045187; GO:0007317; GO:0050804; GO:0040040 Q9VT65; Q03720 "ATP binding; anesthesia-resistant memory; anterior/posterior pattern specification, imaginal disc; behavioral response to ethanol; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase complex; cAMP-mediated signaling; compound eye development; imaginal disc-derived leg morphogenesis; imaginal disc-derived wing morphogenesis; locomotor rhythm; negative regulation of smoothened signaling pathway; olfactory learning; oocyte anterior/posterior axis specification; oocyte microtubule cytoskeleton polarization; plasma membrane; positive regulation of hh target transcription factor activity; regulation of bicoid mRNA localization; regulation of circadian sleep/wake cycle, sleep; regulation of pole plasm oskar mRNA localization; regulation of synaptic transmission; thermosensory behavior" IPR000961; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; cAMP-dependent protein kinase catalytic subunit (PKA C) (EC 2.7.11.11) Pka-C1 CdkA DC0 CG4379 Drosophila melanogaster (Fruit fly) TR41739_c1_g2_i16 P12370 KAPC_DROME 0 GO:0005524; GO:0007615; GO:0007448; GO:0048149; GO:0004691; GO:0005952; GO:0019933; GO:0048749; GO:0007480; GO:0007476; GO:0045475; GO:0045879; GO:0008355; GO:0007314; GO:0008103; GO:0005886; GO:0007228; GO:0008359; GO:0045187; GO:0007317; GO:0050804; GO:0040040 Q9VT65; Q03720 "ATP binding; anesthesia-resistant memory; anterior/posterior pattern specification, imaginal disc; behavioral response to ethanol; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase complex; cAMP-mediated signaling; compound eye development; imaginal disc-derived leg morphogenesis; imaginal disc-derived wing morphogenesis; locomotor rhythm; negative regulation of smoothened signaling pathway; olfactory learning; oocyte anterior/posterior axis specification; oocyte microtubule cytoskeleton polarization; plasma membrane; positive regulation of hh target transcription factor activity; regulation of bicoid mRNA localization; regulation of circadian sleep/wake cycle, sleep; regulation of pole plasm oskar mRNA localization; regulation of synaptic transmission; thermosensory behavior" IPR000961; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; cAMP-dependent protein kinase catalytic subunit (PKA C) (EC 2.7.11.11) Pka-C1 CdkA DC0 CG4379 Drosophila melanogaster (Fruit fly) TR41739_c1_g2_i2 P12370 KAPC_DROME 0 GO:0005524; GO:0007615; GO:0007448; GO:0048149; GO:0004691; GO:0005952; GO:0019933; GO:0048749; GO:0007480; GO:0007476; GO:0045475; GO:0045879; GO:0008355; GO:0007314; GO:0008103; GO:0005886; GO:0007228; GO:0008359; GO:0045187; GO:0007317; GO:0050804; GO:0040040 Q9VT65; Q03720 "ATP binding; anesthesia-resistant memory; anterior/posterior pattern specification, imaginal disc; behavioral response to ethanol; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase complex; cAMP-mediated signaling; compound eye development; imaginal disc-derived leg morphogenesis; imaginal disc-derived wing morphogenesis; locomotor rhythm; negative regulation of smoothened signaling pathway; olfactory learning; oocyte anterior/posterior axis specification; oocyte microtubule cytoskeleton polarization; plasma membrane; positive regulation of hh target transcription factor activity; regulation of bicoid mRNA localization; regulation of circadian sleep/wake cycle, sleep; regulation of pole plasm oskar mRNA localization; regulation of synaptic transmission; thermosensory behavior" IPR000961; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; cAMP-dependent protein kinase catalytic subunit (PKA C) (EC 2.7.11.11) Pka-C1 CdkA DC0 CG4379 Drosophila melanogaster (Fruit fly) TR41739_c1_g2_i3 P21137 KAPC_CAEEL 9.00E-166 GO:0005524; GO:0004691; GO:0005952; GO:1900195 ATP binding; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase complex; positive regulation of oocyte maturation IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; cAMP-dependent protein kinase catalytic subunit (PKA C) (EC 2.7.11.11) kin-1 ZK909.2 Caenorhabditis elegans TR41739_c1_g2_i6 P12370 KAPC_DROME 0 GO:0005524; GO:0007615; GO:0007448; GO:0048149; GO:0004691; GO:0005952; GO:0019933; GO:0048749; GO:0007480; GO:0007476; GO:0045475; GO:0045879; GO:0008355; GO:0007314; GO:0008103; GO:0005886; GO:0007228; GO:0008359; GO:0045187; GO:0007317; GO:0050804; GO:0040040 Q9VT65; Q03720 "ATP binding; anesthesia-resistant memory; anterior/posterior pattern specification, imaginal disc; behavioral response to ethanol; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase complex; cAMP-mediated signaling; compound eye development; imaginal disc-derived leg morphogenesis; imaginal disc-derived wing morphogenesis; locomotor rhythm; negative regulation of smoothened signaling pathway; olfactory learning; oocyte anterior/posterior axis specification; oocyte microtubule cytoskeleton polarization; plasma membrane; positive regulation of hh target transcription factor activity; regulation of bicoid mRNA localization; regulation of circadian sleep/wake cycle, sleep; regulation of pole plasm oskar mRNA localization; regulation of synaptic transmission; thermosensory behavior" IPR000961; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; cAMP-dependent protein kinase catalytic subunit (PKA C) (EC 2.7.11.11) Pka-C1 CdkA DC0 CG4379 Drosophila melanogaster (Fruit fly) TR41740_c0_g1_i1 Q68ED3 PAPD5_MOUSE 8.00E-153 GO:0003677; GO:0006260; GO:0003887; GO:0051301; GO:0005737; GO:0071044; GO:0046872; GO:0007067; GO:0005634 DNA binding; DNA replication; DNA-directed DNA polymerase activity; cell division; cytoplasm; histone mRNA catabolic process; metal ion binding; mitosis; nucleus IPR002934; IPR002058; PAP-associated domain-containing protein 5 (EC 2.7.7.-) (Topoisomerase-related function protein 4-2) (TRF4-2) Papd5 Mus musculus (Mouse) TR41743_c0_g3_i1 Q12019 MDN1_YEAST 1.00E-58 GO:0005524; GO:0016887; GO:0005654; GO:0006461; GO:0006364; GO:0000027 P25382 ATP binding; ATPase activity; nucleoplasm; protein complex assembly; rRNA processing; ribosomal large subunit assembly IPR003593; IPR011704; IPR012099; IPR027417; IPR025662; IPR002035; Midasin (MIDAS-containing protein) (Ribosome export/assembly protein 1) MDN1 REA1 YLR106C L8004.13 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41743_c0_g3_i2 Q9NU22 MDN1_HUMAN 3.00E-101 GO:0005524; GO:0016887; GO:0005730; GO:0005634; GO:0006461; GO:0051082 Q8IZL8 ATP binding; ATPase activity; nucleolus; nucleus; protein complex assembly; unfolded protein binding IPR003593; IPR011704; IPR012099; IPR027417; IPR002035; Midasin (MIDAS-containing protein) MDN1 KIAA0301 Homo sapiens (Human) TR41744_c1_g2_i2 Q6BNL6 YNG2_DEBHA 3.00E-12 GO:0006281; GO:0016568; GO:0007126; GO:0005634; GO:0008270 DNA repair; chromatin modification; meiosis; nucleus; zinc ion binding IPR024610; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Chromatin modification-related protein YNG2 (ING1 homolog 2) YNG2 DEHA2E20746g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR41744_c1_g2_i3 Q9QXV3 ING1_MOUSE 3.00E-24 GO:0007049; GO:0005634; GO:0045893; GO:0006606; GO:0010941; GO:0008270 "cell cycle; nucleus; positive regulation of transcription, DNA-dependent; protein import into nucleus; regulation of cell death; zinc ion binding" IPR024610; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Inhibitor of growth protein 1 Ing1 Mus musculus (Mouse) TR41745_c0_g2_i1 Q9ULT8 HECD1_HUMAN 0 GO:0005737; GO:0046872; GO:0001843; GO:0005634; GO:0042787; GO:0004842 cytoplasm; metal ion binding; neural tube closure; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR002110; IPR020683; IPR011989; IPR016024; IPR008979; IPR000569; IPR010606; IPR012919; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HECTD1 (EC 6.3.2.-) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) HECTD1 KIAA1131 Homo sapiens (Human) TR41745_c0_g2_i2 Q9ULT8 HECD1_HUMAN 0 GO:0005737; GO:0046872; GO:0001843; GO:0005634; GO:0042787; GO:0004842 cytoplasm; metal ion binding; neural tube closure; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR002110; IPR020683; IPR011989; IPR016024; IPR008979; IPR000569; IPR010606; IPR012919; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HECTD1 (EC 6.3.2.-) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) HECTD1 KIAA1131 Homo sapiens (Human) TR41745_c0_g2_i3 Q6WWW4 UPL3_ARATH 5.00E-47 GO:0042023; GO:0005886; GO:0042787; GO:0010091; GO:0004842 DNA endoreduplication; plasma membrane; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; trichome branching; ubiquitin-protein ligase activity IPR011989; IPR016024; IPR000225; IPR000569; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UPL3 (Ubiquitin-protein ligase 3) (EC 6.3.2.-) (HECT ubiquitin-protein ligase 3) (Protein KAKTUS) UPL3 KAK At4g38600/At4g38610 F20M13.160/F20M13.170 Arabidopsis thaliana (Mouse-ear cress) TR41745_c0_g3_i1 Q9ULT8 HECD1_HUMAN 0 GO:0005737; GO:0046872; GO:0001843; GO:0005634; GO:0042787; GO:0004842 cytoplasm; metal ion binding; neural tube closure; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR002110; IPR020683; IPR011989; IPR016024; IPR008979; IPR000569; IPR010606; IPR012919; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HECTD1 (EC 6.3.2.-) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) HECTD1 KIAA1131 Homo sapiens (Human) TR41747_c7_g5_i2 O45218 ADAS_CAEEL 0 GO:0071949; GO:0008762; GO:0008609; GO:0008611; GO:0005777 FAD binding; UDP-N-acetylmuramate dehydrogenase activity; alkylglycerone-phosphate synthase activity; ether lipid biosynthetic process; peroxisome IPR025650; IPR016169; IPR016166; IPR016167; IPR016164; IPR004113; IPR006094; Glycerolipid metabolism; ether lipid biosynthesis. Alkyldihydroxyacetonephosphate synthase (Alkyl-DHAP synthase) (EC 2.5.1.26) (Alkylglycerone-phosphate synthase) ads-1 Y50D7A.7 Caenorhabditis elegans TR41747_c7_g5_i4 P97275 ADAS_CAVPO 0 GO:0071949; GO:0008762; GO:0008609; GO:0008611; GO:0005778 FAD binding; UDP-N-acetylmuramate dehydrogenase activity; alkylglycerone-phosphate synthase activity; ether lipid biosynthetic process; peroxisomal membrane IPR025650; IPR016169; IPR016166; IPR016167; IPR016164; IPR004113; IPR006094; Glycerolipid metabolism; ether lipid biosynthesis. "Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Alkylglycerone-phosphate synthase)" AGPS Cavia porcellus (Guinea pig) TR41747_c7_g5_i5 P97275 ADAS_CAVPO 0 GO:0071949; GO:0008762; GO:0008609; GO:0008611; GO:0005778 FAD binding; UDP-N-acetylmuramate dehydrogenase activity; alkylglycerone-phosphate synthase activity; ether lipid biosynthetic process; peroxisomal membrane IPR025650; IPR016169; IPR016166; IPR016167; IPR016164; IPR004113; IPR006094; Glycerolipid metabolism; ether lipid biosynthesis. "Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Alkylglycerone-phosphate synthase)" AGPS Cavia porcellus (Guinea pig) TR41749_c1_g5_i2 Q8VHI6 WASF3_MOUSE 2.00E-15 GO:0030036; GO:0005737; GO:0005856; GO:0007010; GO:0030027; GO:0030032; GO:0014003; GO:0031643; GO:0008360 actin cytoskeleton organization; cytoplasm; cytoskeleton; cytoskeleton organization; lamellipodium; lamellipodium assembly; oligodendrocyte development; positive regulation of myelination; regulation of cell shape IPR028288; IPR003124; Wiskott-Aldrich syndrome protein family member 3 (WASP family protein member 3) (Protein WAVE-3) Wasf3 Wave3 Mus musculus (Mouse) TR41751_c1_g1_i2 Q5M883 CLIC2_RAT 1.00E-37 GO:0034707; GO:0005737; GO:0004602; GO:0060315; GO:0051099; GO:0010880; GO:0005247 chloride channel complex; cytoplasm; glutathione peroxidase activity; negative regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of binding; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; voltage-gated chloride channel activity IPR010987; IPR004045; IPR002946; IPR012336; Chloride intracellular channel protein 2 Clic2 Rattus norvegicus (Rat) TR41753_c0_g1_i1 Q6UX71 PXDC2_HUMAN 1.00E-50 GO:0016021; GO:0007275; GO:0004872 A2APF7 integral to membrane; multicellular organismal development; receptor activity IPR016201; IPR002165; Plexin domain-containing protein 2 (Tumor endothelial marker 7-related protein) PLXDC2 TEM7R UNQ2514/PRO6003 Homo sapiens (Human) TR41753_c0_g1_i6 Q9DC11 PXDC2_MOUSE 2.00E-50 GO:0016021; GO:0007275; GO:0005886; GO:0004872 integral to membrane; multicellular organismal development; plasma membrane; receptor activity IPR016201; IPR002165; Plexin domain-containing protein 2 (Tumor endothelial marker 7-related protein) Plxdc2 Tem7r Mus musculus (Mouse) TR41754_c1_g1_i1 O95822 DCMC_HUMAN 7.00E-141 GO:0006085; GO:0005829; GO:0006633; GO:0019395; GO:2001294; GO:0050080; GO:0005759; GO:0005782; GO:0046321; GO:0031998; GO:0010906; GO:0002931 acetyl-CoA biosynthetic process; cytosol; fatty acid biosynthetic process; fatty acid oxidation; malonyl-CoA catabolic process; malonyl-CoA decarboxylase activity; mitochondrial matrix; peroxisomal matrix; positive regulation of fatty acid oxidation; regulation of fatty acid beta-oxidation; regulation of glucose metabolic process; response to ischemia IPR007956; Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from malonyl-CoA: step 1/1. "Malonyl-CoA decarboxylase, mitochondrial (MCD) (EC 4.1.1.9)" MLYCD Homo sapiens (Human) TR41754_c1_g1_i4 O95822 DCMC_HUMAN 3.00E-136 GO:0006085; GO:0005829; GO:0006633; GO:0019395; GO:2001294; GO:0050080; GO:0005759; GO:0005782; GO:0046321; GO:0031998; GO:0010906; GO:0002931 acetyl-CoA biosynthetic process; cytosol; fatty acid biosynthetic process; fatty acid oxidation; malonyl-CoA catabolic process; malonyl-CoA decarboxylase activity; mitochondrial matrix; peroxisomal matrix; positive regulation of fatty acid oxidation; regulation of fatty acid beta-oxidation; regulation of glucose metabolic process; response to ischemia IPR007956; Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from malonyl-CoA: step 1/1. "Malonyl-CoA decarboxylase, mitochondrial (MCD) (EC 4.1.1.9)" MLYCD Homo sapiens (Human) TR41755_c1_g3_i1 Q552R1 DCAF7_DICDI 2.00E-150 IPR015943; IPR001680; IPR019775; IPR017986; DDB1- and CUL4-associated factor 7 homolog (WD repeat-containing protein 68 homolog) wdr68 DDB_G0275925 Dictyostelium discoideum (Slime mold) TR41755_c1_g3_i2 P61963 DCAF7_MOUSE 0 GO:0080008; GO:0005737; GO:0007275; GO:0005634; GO:0016567 Cul4-RING ubiquitin ligase complex; cytoplasm; multicellular organismal development; nucleus; protein ubiquitination IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog) Dcaf7 Han11 Wdr68 Mus musculus (Mouse) TR41756_c0_g1_i1 Q03963 E2AK2_MOUSE 9.00E-34 GO:0005524; GO:0000186; GO:0051607; GO:0003725; GO:0030968; GO:0045087; GO:0033689; GO:0017148; GO:0045071; GO:0004715; GO:0005634; GO:0018108; GO:0048471; GO:0051092; GO:1901224; GO:0032722; GO:0032874; GO:0046777; GO:0004672; GO:0004674; GO:1900225; GO:1901532; GO:1902036; GO:1902033; GO:0035455; GO:0009615; GO:0006351; GO:0006412; GO:0006926 P35569 "ATP binding; activation of MAPKK activity; defense response to virus; double-stranded RNA binding; endoplasmic reticulum unfolded protein response; innate immune response; negative regulation of osteoblast proliferation; negative regulation of translation; negative regulation of viral genome replication; non-membrane spanning protein tyrosine kinase activity; nucleus; peptidyl-tyrosine phosphorylation; perinuclear region of cytoplasm; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB cascade; positive regulation of chemokine production; positive regulation of stress-activated MAPK cascade; protein autophosphorylation; protein kinase activity; protein serine/threonine kinase activity; regulation of NLRP3 inflammasome complex assembly; regulation of hematopoietic progenitor cell differentiation; regulation of hematopoietic stem cell differentiation; regulation of hematopoietic stem cell proliferation; response to interferon-alpha; response to virus; transcription, DNA-dependent; translation; virus-infected cell apoptotic process" IPR014720; IPR011009; IPR000719; IPR017441; IPR008271; "Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Serine/threonine-protein kinase TIK) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)" Eif2ak2 Pkr Prkr Tik Mus musculus (Mouse) TR41756_c0_g1_i2 Q9NZJ5 E2AK3_HUMAN 0 GO:0005524; GO:0006983; GO:0032933; GO:0006919; GO:0006987; GO:0030282; GO:0019722; GO:0002063; GO:0031018; GO:0005789; GO:0007029; GO:0004694; GO:0045444; GO:0030073; GO:0048009; GO:0016021; GO:0007595; GO:0031642; GO:0032057; GO:0032092; GO:0009967; GO:0046777; GO:0051260; GO:0019217; GO:0006412; GO:0006926 Itself ATP binding; ER overload response; SREBP signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of signaling protein activity involved in unfolded protein response; bone mineralization; calcium-mediated signaling; chondrocyte development; endocrine pancreas development; endoplasmic reticulum membrane; endoplasmic reticulum organization; eukaryotic translation initiation factor 2alpha kinase activity; fat cell differentiation; insulin secretion; insulin-like growth factor receptor signaling pathway; integral to membrane; lactation; negative regulation of myelination; negative regulation of translational initiation in response to stress; positive regulation of protein binding; positive regulation of signal transduction; protein autophosphorylation; protein homooligomerization; regulation of fatty acid metabolic process; translation; virus-infected cell apoptotic process IPR011009; IPR000719; IPR017441; IPR027295; IPR011047; IPR008271; Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) EIF2AK3 PEK PERK Homo sapiens (Human) TR41756_c0_g1_i3 Q54VV7 Y0111_DICDI 2.00E-08 GO:0005524; GO:0005543; GO:0004674 ATP binding; phospholipid binding; protein serine/threonine kinase activity IPR011417; IPR011009; IPR000719; IPR008271; Probable serine/threonine-protein kinase DDB_G0280111 (EC 2.7.11.1) DDB_G0280111 Dictyostelium discoideum (Slime mold) TR41756_c0_g1_i6 Q9NZJ5 E2AK3_HUMAN 0 GO:0005524; GO:0006983; GO:0032933; GO:0006919; GO:0006987; GO:0030282; GO:0019722; GO:0002063; GO:0031018; GO:0005789; GO:0007029; GO:0004694; GO:0045444; GO:0030073; GO:0048009; GO:0016021; GO:0007595; GO:0031642; GO:0032057; GO:0032092; GO:0009967; GO:0046777; GO:0051260; GO:0019217; GO:0006412; GO:0006926 Itself ATP binding; ER overload response; SREBP signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of signaling protein activity involved in unfolded protein response; bone mineralization; calcium-mediated signaling; chondrocyte development; endocrine pancreas development; endoplasmic reticulum membrane; endoplasmic reticulum organization; eukaryotic translation initiation factor 2alpha kinase activity; fat cell differentiation; insulin secretion; insulin-like growth factor receptor signaling pathway; integral to membrane; lactation; negative regulation of myelination; negative regulation of translational initiation in response to stress; positive regulation of protein binding; positive regulation of signal transduction; protein autophosphorylation; protein homooligomerization; regulation of fatty acid metabolic process; translation; virus-infected cell apoptotic process IPR011009; IPR000719; IPR017441; IPR027295; IPR011047; IPR008271; Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) EIF2AK3 PEK PERK Homo sapiens (Human) TR41759_c1_g1_i1 Q00228 CYB_MYTED 0 GO:0009055; GO:0016021; GO:0046872; GO:0005743; GO:0016491; GO:0070469; GO:0022904 electron carrier activity; integral to membrane; metal ion binding; mitochondrial inner membrane; oxidoreductase activity; respiratory chain; respiratory electron transport chain IPR016175; IPR005798; IPR005797; IPR027387; IPR016174; Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit) MT-CYB COB CYTB MTCYB Mytilus edulis (Blue mussel) TR41759_c1_g1_i2 Q00227 COX2_MYTED 8.00E-133 GO:0005507; GO:0004129; GO:0022900; GO:0016021; GO:0005743; GO:0070469 copper ion binding; cytochrome-c oxidase activity; electron transport chain; integral to membrane; mitochondrial inner membrane; respiratory chain IPR001505; IPR008972; IPR002429; IPR011759; Cytochrome c oxidase subunit 2 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide II) COII Mytilus edulis (Blue mussel) TR41759_c1_g1_i3 Q00228 CYB_MYTED 0 GO:0009055; GO:0016021; GO:0046872; GO:0005743; GO:0016491; GO:0070469; GO:0022904 electron carrier activity; integral to membrane; metal ion binding; mitochondrial inner membrane; oxidoreductase activity; respiratory chain; respiratory electron transport chain IPR016175; IPR005798; IPR005797; IPR027387; IPR016174; Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit) MT-CYB COB CYTB MTCYB Mytilus edulis (Blue mussel) TR41760_c0_g1_i1 Q10068 YAN2_SCHPO 3.00E-16 GO:0005829; GO:0046872; GO:0004222; GO:0005634; GO:0006508 cytosol; metal ion binding; metalloendopeptidase activity; nucleus; proteolysis IPR011249; IPR011237; IPR011765; IPR007863; Uncharacterized protein C3H1.02c SPAC3H1.02c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41760_c0_g1_i3 P48053 YPD1_CAEEL 1.00E-176 GO:0003824; GO:0008152; GO:0046872 catalytic activity; metabolic process; metal ion binding IPR011249; IPR011237; IPR011765; IPR007863; Uncharacterized protein C05D11.1 C05D11.1 Caenorhabditis elegans TR41762_c0_g1_i1 P12024 CHAO_DROME 5.00E-15 GO:0007156; GO:0005886; GO:0050896; GO:0016028; GO:0042052; GO:0007601 homophilic cell adhesion; plasma membrane; response to stimulus; rhabdomere; rhabdomere development; visual perception IPR000225; IPR001611; IPR003591; Chaoptin (Photoreceptor cell-specific membrane protein) chp CHT CG1744 Drosophila melanogaster (Fruit fly) TR41762_c0_g1_i2 Q9DBB9 CPN2_MOUSE 4.00E-13 GO:0005576 extracellular region IPR000483; IPR001611; IPR025875; IPR003591; IPR000372; Carboxypeptidase N subunit 2 (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N large subunit) (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N regulatory subunit) Cpn2 Mus musculus (Mouse) TR41762_c0_g1_i3 Q9DBB9 CPN2_MOUSE 5.00E-13 GO:0005576 extracellular region IPR000483; IPR001611; IPR025875; IPR003591; IPR000372; Carboxypeptidase N subunit 2 (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N large subunit) (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N regulatory subunit) Cpn2 Mus musculus (Mouse) TR41762_c0_g2_i2 Q96PE1 GP124_HUMAN 3.00E-06 GO:0004930; GO:0009986; GO:0007417; GO:0043542; GO:0016021; GO:1900747; GO:0007218; GO:0005886; GO:0010595; GO:0045765; GO:0050920; GO:0090210; GO:0002040 G-protein coupled receptor activity; cell surface; central nervous system development; endothelial cell migration; integral to membrane; negative regulation of vascular endothelial growth factor signaling pathway; neuropeptide signaling pathway; plasma membrane; positive regulation of endothelial cell migration; regulation of angiogenesis; regulation of chemotaxis; regulation of establishment of blood-brain barrier; sprouting angiogenesis IPR000483; IPR017981; IPR001879; IPR000832; IPR017983; IPR000203; IPR007110; IPR013783; IPR003599; IPR001611; IPR003591; G-protein coupled receptor 124 (Tumor endothelial marker 5) GPR124 KIAA1531 TEM5 Homo sapiens (Human) TR41763_c0_g2_i1 Q9JKU3 IF172_RAT 0 GO:0005929; GO:0042384; GO:0007275; GO:0000122; GO:0005634; GO:0008134 cilium; cilium assembly; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription factor binding IPR011042; IPR016024; IPR015943; IPR001680; IPR017986; Intraflagellar transport protein 172 homolog (Selective LIM-binding factor) Ift172 Slb Rattus norvegicus (Rat) TR41764_c0_g1_i1 Q25531 VA0D_MANSE 0 GO:0015991; GO:0015078; GO:0033179 "ATP hydrolysis coupled proton transport; hydrogen ion transmembrane transporter activity; proton-transporting V-type ATPase, V0 domain" IPR002843; IPR016727; V-type proton ATPase subunit d (V-ATPase subunit d) (M40) (V-ATPase 40 kDa subunit) (Vacuolar proton pump subunit d) Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) TR41765_c1_g2_i2 Q09575 YRD6_CAEEL 3.00E-20 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR41765_c1_g3_i1 P10394 POL4_DROME 1.00E-42 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR41767_c1_g2_i3 P21329 RTJK_DROFU 2.00E-13 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) TR41767_c1_g2_i5 Q95SX7 RTBS_DROME 8.00E-06 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR41768_c3_g1_i1 A7MBL8 PKN2_DANRE 0 GO:0005524; GO:0007155; GO:0007049; GO:0051301; GO:0030054; GO:0032154; GO:0005737; GO:0005856; GO:0030027; GO:0016020; GO:0030496; GO:0005634; GO:0004697; GO:0006355; GO:0007165; GO:0006351 "ATP binding; cell adhesion; cell cycle; cell division; cell junction; cleavage furrow; cytoplasm; cytoskeleton; lamellipodium; membrane; midbody; nucleus; protein kinase C activity; regulation of transcription, DNA-dependent; signal transduction; transcription, DNA-dependent" IPR000961; IPR000008; IPR011072; IPR011009; IPR017892; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) pkn2 prk2 prkcl2 zgc:153916 Danio rerio (Zebrafish) (Brachydanio rerio) TR41768_c3_g1_i2 Q6P7N4 CC037_XENTR 2.00E-92 IPR003738; Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein (ES cell-specific 5hmC-binding protein) (Putative peptidase SRAPD1) (EC 3.4.-.-) (SRAP domain-containing protein 1) hmces srapd1 TGas027m07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41769_c7_g1_i1 A2VDP4 ZN567_BOVIN 1.00E-17 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 567 ZNF567 Bos taurus (Bovine) TR41770_c0_g1_i2 Q12893 TM115_HUMAN 9.00E-91 GO:0005794; GO:0016021; GO:0008285; GO:0005634 Golgi apparatus; integral to membrane; negative regulation of cell proliferation; nucleus IPR013861; Transmembrane protein 115 (Placental protein 6) (PP6) (Protein PL6) TMEM115 PL6 LUCA11.2 Homo sapiens (Human) TR41770_c0_g1_i6 Q12893 TM115_HUMAN 1.00E-89 GO:0005794; GO:0016021; GO:0008285; GO:0005634 Golgi apparatus; integral to membrane; negative regulation of cell proliferation; nucleus IPR013861; Transmembrane protein 115 (Placental protein 6) (PP6) (Protein PL6) TMEM115 PL6 LUCA11.2 Homo sapiens (Human) TR41772_c2_g1_i1 Q68F72 S15A4_XENLA 4.00E-96 GO:0016021; GO:0006857; GO:0015031; GO:0015293 integral to membrane; oligopeptide transport; protein transport; symporter activity IPR016196; IPR000109; IPR018456; Solute carrier family 15 member 4 (Peptide transporter 4) slc15a4 Xenopus laevis (African clawed frog) TR41772_c2_g1_i4 Q03278 PO21_NASVI 4.00E-11 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR000477; IPR007087; IPR015880; Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 (Retrovirus-related Pol polyprotein from type I retrotransposable element R2) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] (Fragment) Nasonia vitripennis (Parasitic wasp) TR41772_c2_g1_i7 O09014 S15A4_RAT 8.00E-98 GO:0005290; GO:0016021; GO:0006857; GO:0015031; GO:0015293 L-histidine transmembrane transporter activity; integral to membrane; oligopeptide transport; protein transport; symporter activity IPR016196; IPR000109; IPR018456; Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (rPHT1) Slc15a4 Pht1 Rattus norvegicus (Rat) TR41775_c2_g1_i1 O95639 CPSF4_HUMAN 7.00E-113 GO:0003723; GO:0005847; GO:0006397; GO:0005739; GO:0046778; GO:0019058; GO:0008270 RNA binding; mRNA cleavage and polyadenylation specificity factor complex; mRNA processing; mitochondrion; modification by virus of host mRNA processing; viral life cycle; zinc ion binding IPR000571; IPR001878; Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog) CPSF4 CPSF30 NAR NEB1 Homo sapiens (Human) TR41775_c2_g1_i2 Q8CHP0 ZC3H3_MOUSE 6.00E-14 GO:0070412; GO:0005847; GO:0006378; GO:0046872; GO:0016973; GO:0032927; GO:0010793 R-SMAD binding; mRNA cleavage and polyadenylation specificity factor complex; mRNA polyadenylation; metal ion binding; poly(A)+ mRNA export from nucleus; positive regulation of activin receptor signaling pathway; regulation of mRNA export from nucleus IPR000571; Zinc finger CCCH domain-containing protein 3 Zc3h3 Kiaa0150 Zc3hdc3 Zfp623 Mus musculus (Mouse) TR41775_c2_g1_i4 O19137 CPSF4_BOVIN 7.00E-98 GO:0003723; GO:0005847; GO:0006397; GO:0005739; GO:0008270 P03120 RNA binding; mRNA cleavage and polyadenylation specificity factor complex; mRNA processing; mitochondrion; zinc ion binding IPR000571; IPR001878; Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) CPSF4 CPSF30 Bos taurus (Bovine) TR41775_c2_g2_i1 Q5XM24 APRA_DICDI 4.00E-86 GO:0007049; GO:0005576; GO:0005622; GO:0008285; GO:0043234; GO:0031157; GO:0030435 cell cycle; extracellular region; intracellular; negative regulation of cell proliferation; protein complex; regulation of aggregate size involved in sorocarp development; sporulation resulting in formation of a cellular spore IPR009199; Autocrine proliferation repressor protein A (PhoPQ-activated pathogenicity-related protein) aprA DDB_G0281663 Dictyostelium discoideum (Slime mold) TR41775_c2_g2_i2 Q5XM24 APRA_DICDI 6.00E-14 GO:0007049; GO:0005576; GO:0005622; GO:0008285; GO:0043234; GO:0031157; GO:0030435 cell cycle; extracellular region; intracellular; negative regulation of cell proliferation; protein complex; regulation of aggregate size involved in sorocarp development; sporulation resulting in formation of a cellular spore IPR009199; Autocrine proliferation repressor protein A (PhoPQ-activated pathogenicity-related protein) aprA DDB_G0281663 Dictyostelium discoideum (Slime mold) TR41775_c2_g3_i1 O95639 CPSF4_HUMAN 9.00E-54 GO:0003723; GO:0005847; GO:0006397; GO:0005739; GO:0046778; GO:0019058; GO:0008270 RNA binding; mRNA cleavage and polyadenylation specificity factor complex; mRNA processing; mitochondrion; modification by virus of host mRNA processing; viral life cycle; zinc ion binding IPR000571; IPR001878; Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog) CPSF4 CPSF30 NAR NEB1 Homo sapiens (Human) TR41776_c1_g1_i10 Q9ESN4 C1QL3_MOUSE 1.00E-08 GO:0005581; GO:0005576; GO:0050807 collagen; extracellular region; regulation of synapse organization IPR001073; IPR008160; IPR008983; Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13) (CTRP13) (Gliacolin) C1ql3 C1ql Ctrp13 Mus musculus (Mouse) TR41776_c1_g1_i11 P83425 HIP_MYTED 1.00E-15 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR41776_c1_g1_i4 Q00780 CO8A1_MOUSE 6.00E-08 GO:0001525; GO:0005604; GO:0048593; GO:0007155; GO:0005581; GO:0050673; GO:0010811 angiogenesis; basement membrane; camera-type eye morphogenesis; cell adhesion; collagen; epithelial cell proliferation; positive regulation of cell-substrate adhesion IPR001073; IPR008160; IPR008983; Collagen alpha-1(VIII) chain [Cleaved into: Vastatin] Col8a1 Mus musculus (Mouse) TR41776_c1_g1_i7 Q9ESN4 C1QL3_MOUSE 5.00E-08 GO:0005581; GO:0005576; GO:0050807 collagen; extracellular region; regulation of synapse organization IPR001073; IPR008160; IPR008983; Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13) (CTRP13) (Gliacolin) C1ql3 C1ql Ctrp13 Mus musculus (Mouse) TR41776_c1_g1_i8 P83425 HIP_MYTED 6.00E-16 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR41777_c0_g1_i3 P16554 NUMB_DROME 8.00E-100 GO:0005524; GO:0061382; GO:0005112; GO:0007219; GO:0055059; GO:0045180; GO:0035050; GO:0008347; GO:0042694; GO:0045746; GO:0007400; GO:0005634; GO:0061320; GO:0007422; GO:0045807; GO:0008104; GO:0009786; GO:0050767; GO:0007622; GO:0045035; GO:0016360; GO:0007419 Q05513 ATP binding; Malpighian tubule tip cell differentiation; Notch binding; Notch signaling pathway; asymmetric neuroblast division; basal cortex; embryonic heart tube development; glial cell migration; muscle cell fate specification; negative regulation of Notch signaling pathway; neuroblast fate determination; nucleus; pericardial nephrocyte differentiation; peripheral nervous system development; positive regulation of endocytosis; protein localization; regulation of asymmetric cell division; regulation of neurogenesis; rhythmic behavior; sensory organ precursor cell division; sensory organ precursor cell fate determination; ventral cord development IPR016698; IPR010449; IPR011993; IPR006020; Protein numb numb CG3779 Drosophila melanogaster (Fruit fly) TR41778_c1_g2_i3 Q64017 GP176_RAT 3.00E-06 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR000276; IPR017452; Probable G-protein coupled receptor 176 (G-protein coupled receptor AGR9) (RBU-15) Gpr176 Agr9 Gm1012 Rattus norvegicus (Rat) TR41779_c5_g2_i1 P52632 STA5B_RAT 9.00E-82 GO:0006103; GO:0007259; GO:0060397; GO:0048541; GO:0000979; GO:0033077; GO:0043029; GO:0006953; GO:0000255; GO:0005509; GO:0006101; GO:0006600; GO:0046449; GO:0005829; GO:0046543; GO:0046544; GO:0003690; GO:0006631; GO:0007565; GO:0006549; GO:0007595; GO:0019915; GO:0001889; GO:0001553; GO:0001779; GO:0043066; GO:0045647; GO:0005634; GO:0006107; GO:0045579; GO:0042104; GO:0051272; GO:0045588; GO:0050729; GO:0045086; GO:0045931; GO:0040018; GO:0032825; GO:0045954; GO:0032819; GO:0048661; GO:0045944; GO:0042448; GO:0038161; GO:0030155; GO:0030856; GO:0019218; GO:0032355; GO:0045471; GO:0001666; GO:0070672; GO:0070669; GO:0070670; GO:0032496; GO:0043434; GO:0043565; GO:0003700; GO:0004871; GO:0006105; GO:0019530; GO:0006366; GO:0006573 2-oxoglutarate metabolic process; JAK-STAT cascade; JAK-STAT cascade involved in growth hormone signaling pathway; Peyer's patch development; RNA polymerase II core promoter sequence-specific DNA binding; T cell differentiation in thymus; T cell homeostasis; acute-phase response; allantoin metabolic process; calcium ion binding; citrate metabolic process; creatine metabolic process; creatinine metabolic process; cytosol; development of secondary female sexual characteristics; development of secondary male sexual characteristics; double-stranded DNA binding; fatty acid metabolic process; female pregnancy; isoleucine metabolic process; lactation; lipid storage; liver development; luteinization; natural killer cell differentiation; negative regulation of apoptotic process; negative regulation of erythrocyte differentiation; nucleus; oxaloacetate metabolic process; positive regulation of B cell differentiation; positive regulation of activated T cell proliferation; positive regulation of cellular component movement; positive regulation of gamma-delta T cell differentiation; positive regulation of inflammatory response; positive regulation of interleukin-2 biosynthetic process; positive regulation of mitotic cell cycle; positive regulation of multicellular organism growth; positive regulation of natural killer cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; progesterone metabolic process; prolactin signaling pathway; regulation of cell adhesion; regulation of epithelial cell differentiation; regulation of steroid metabolic process; response to estradiol stimulus; response to ethanol; response to hypoxia; response to interleukin-15; response to interleukin-2; response to interleukin-4; response to lipopolysaccharide; response to peptide hormone stimulus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; signal transducer activity; succinate metabolic process; taurine metabolic process; transcription from RNA polymerase II promoter; valine metabolic process IPR011992; IPR008967; IPR000980; IPR001217; IPR013800; IPR015988; IPR013801; IPR012345; IPR013799; Signal transducer and activator of transcription 5B Stat5b Rattus norvegicus (Rat) TR41779_c5_g2_i3 P52632 STA5B_RAT 1.00E-82 GO:0006103; GO:0007259; GO:0060397; GO:0048541; GO:0000979; GO:0033077; GO:0043029; GO:0006953; GO:0000255; GO:0005509; GO:0006101; GO:0006600; GO:0046449; GO:0005829; GO:0046543; GO:0046544; GO:0003690; GO:0006631; GO:0007565; GO:0006549; GO:0007595; GO:0019915; GO:0001889; GO:0001553; GO:0001779; GO:0043066; GO:0045647; GO:0005634; GO:0006107; GO:0045579; GO:0042104; GO:0051272; GO:0045588; GO:0050729; GO:0045086; GO:0045931; GO:0040018; GO:0032825; GO:0045954; GO:0032819; GO:0048661; GO:0045944; GO:0042448; GO:0038161; GO:0030155; GO:0030856; GO:0019218; GO:0032355; GO:0045471; GO:0001666; GO:0070672; GO:0070669; GO:0070670; GO:0032496; GO:0043434; GO:0043565; GO:0003700; GO:0004871; GO:0006105; GO:0019530; GO:0006366; GO:0006573 2-oxoglutarate metabolic process; JAK-STAT cascade; JAK-STAT cascade involved in growth hormone signaling pathway; Peyer's patch development; RNA polymerase II core promoter sequence-specific DNA binding; T cell differentiation in thymus; T cell homeostasis; acute-phase response; allantoin metabolic process; calcium ion binding; citrate metabolic process; creatine metabolic process; creatinine metabolic process; cytosol; development of secondary female sexual characteristics; development of secondary male sexual characteristics; double-stranded DNA binding; fatty acid metabolic process; female pregnancy; isoleucine metabolic process; lactation; lipid storage; liver development; luteinization; natural killer cell differentiation; negative regulation of apoptotic process; negative regulation of erythrocyte differentiation; nucleus; oxaloacetate metabolic process; positive regulation of B cell differentiation; positive regulation of activated T cell proliferation; positive regulation of cellular component movement; positive regulation of gamma-delta T cell differentiation; positive regulation of inflammatory response; positive regulation of interleukin-2 biosynthetic process; positive regulation of mitotic cell cycle; positive regulation of multicellular organism growth; positive regulation of natural killer cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; progesterone metabolic process; prolactin signaling pathway; regulation of cell adhesion; regulation of epithelial cell differentiation; regulation of steroid metabolic process; response to estradiol stimulus; response to ethanol; response to hypoxia; response to interleukin-15; response to interleukin-2; response to interleukin-4; response to lipopolysaccharide; response to peptide hormone stimulus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; signal transducer activity; succinate metabolic process; taurine metabolic process; transcription from RNA polymerase II promoter; valine metabolic process IPR011992; IPR008967; IPR000980; IPR001217; IPR013800; IPR015988; IPR013801; IPR012345; IPR013799; Signal transducer and activator of transcription 5B Stat5b Rattus norvegicus (Rat) TR41780_c0_g1_i1 P47842 GTR3_CANFA 1.00E-83 GO:0005355; GO:0015758; GO:0016021 glucose transmembrane transporter activity; glucose transport; integral to membrane IPR002945; IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3)" SLC2A3 GLUT3 Canis familiaris (Dog) (Canis lupus familiaris) TR41780_c0_g1_i2 P11167 GTR1_RAT 2.00E-89 GO:0055056; GO:0005901; GO:0005911; GO:0030864; GO:0033300; GO:0016021; GO:0042470; GO:0030496; GO:0006461; GO:0043621; GO:0006970; GO:0005351; GO:0042910 D-glucose transmembrane transporter activity; caveola; cell-cell junction; cortical actin cytoskeleton; dehydroascorbic acid transporter activity; integral to membrane; melanosome; midbody; protein complex assembly; protein self-association; response to osmotic stress; sugar:hydrogen symporter activity; xenobiotic transporter activity IPR002439; IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1)" Slc2a1 Glut-1 Glut1 Rattus norvegicus (Rat) TR41780_c0_g1_i5 P58353 GTR5_BOVIN 1.00E-78 GO:0016324; GO:0071332; GO:0005353; GO:0016021 apical plasma membrane; cellular response to fructose stimulus; fructose transmembrane transporter activity; integral to membrane IPR002442; IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5)" SLC2A5 GLUT5 Bos taurus (Bovine) TR41780_c0_g1_i6 P47842 GTR3_CANFA 5.00E-87 GO:0005355; GO:0015758; GO:0016021 glucose transmembrane transporter activity; glucose transport; integral to membrane IPR002945; IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3)" SLC2A3 GLUT3 Canis familiaris (Dog) (Canis lupus familiaris) TR41780_c0_g1_i8 P11167 GTR1_RAT 6.00E-92 GO:0055056; GO:0005901; GO:0005911; GO:0030864; GO:0033300; GO:0016021; GO:0042470; GO:0030496; GO:0006461; GO:0043621; GO:0006970; GO:0005351; GO:0042910 D-glucose transmembrane transporter activity; caveola; cell-cell junction; cortical actin cytoskeleton; dehydroascorbic acid transporter activity; integral to membrane; melanosome; midbody; protein complex assembly; protein self-association; response to osmotic stress; sugar:hydrogen symporter activity; xenobiotic transporter activity IPR002439; IPR020846; IPR016196; IPR005828; IPR003663; IPR005829; "Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1)" Slc2a1 Glut-1 Glut1 Rattus norvegicus (Rat) TR41781_c0_g2_i2 Q95SX7 RTBS_DROME 9.00E-45 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR41782_c0_g1_i1 Q6NRG5 NDOR1_XENLA 0 GO:0010181; GO:0008219; GO:0036245; GO:0005829; GO:0005506; GO:0016491; GO:0048471 FMN binding; cell death; cellular response to menadione; cytosol; iron ion binding; oxidoreductase activity; perinuclear region of cytoplasm IPR003097; IPR017927; IPR001094; IPR008254; IPR001709; IPR023173; IPR001433; IPR017938; NADPH-dependent diflavin oxidoreductase 1 (EC 1.6.-.-) (NADPH-dependent FMN and FAD-containing oxidoreductase) ndor1 Xenopus laevis (African clawed frog) TR41782_c0_g1_i2 Q8DCK2 CYSJ_VIBVU 6.00E-70 GO:0010181; GO:0019344; GO:0050660; GO:0070814; GO:0005506; GO:0000103; GO:0004783 FMN binding; cysteine biosynthetic process; flavin adenine dinucleotide binding; hydrogen sulfide biosynthetic process; iron ion binding; sulfate assimilation; sulfite reductase (NADPH) activity IPR010199; IPR003097; IPR017927; IPR001094; IPR008254; IPR001709; IPR023173; IPR001433; IPR017938; Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1. Sulfite reductase [NADPH] flavoprotein alpha-component (SiR-FP) (EC 1.8.1.2) cysJ VV1_1402 Vibrio vulnificus (strain CMCP6) TR41782_c0_g1_i4 Q6NRG5 NDOR1_XENLA 0 GO:0010181; GO:0008219; GO:0036245; GO:0005829; GO:0005506; GO:0016491; GO:0048471 FMN binding; cell death; cellular response to menadione; cytosol; iron ion binding; oxidoreductase activity; perinuclear region of cytoplasm IPR003097; IPR017927; IPR001094; IPR008254; IPR001709; IPR023173; IPR001433; IPR017938; NADPH-dependent diflavin oxidoreductase 1 (EC 1.6.-.-) (NADPH-dependent FMN and FAD-containing oxidoreductase) ndor1 Xenopus laevis (African clawed frog) TR41782_c0_g1_i5 P38039 CYSJ_SALTY 1.00E-41 GO:0010181; GO:0019344; GO:0050660; GO:0070814; GO:0005506; GO:0000103; GO:0004783 FMN binding; cysteine biosynthetic process; flavin adenine dinucleotide binding; hydrogen sulfide biosynthetic process; iron ion binding; sulfate assimilation; sulfite reductase (NADPH) activity IPR010199; IPR003097; IPR017927; IPR001094; IPR008254; IPR001709; IPR023173; IPR001433; IPR017938; Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1. Sulfite reductase [NADPH] flavoprotein alpha-component (SiR-FP) (EC 1.8.1.2) cysJ STM2948 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) TR41782_c0_g1_i7 Q54JL0 NDOR1_DICDI 3.00E-82 GO:0010181; GO:0050661; GO:0003958; GO:0005829; GO:0050660; GO:0005506; GO:0016709 "FMN binding; NADP binding; NADPH-hemoprotein reductase activity; cytosol; flavin adenine dinucleotide binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen" IPR003097; IPR017927; IPR001094; IPR008254; IPR001709; IPR023173; IPR001433; IPR017938; NADPH-dependent diflavin oxidoreductase 1 (EC 1.6.-.-) (NADPH oxidoreductase C) (NADPH-dependent FMN and FAD-containing oxidoreductase) redC ndor1 DDB_G0287983 Dictyostelium discoideum (Slime mold) TR41783_c0_g1_i1 P55010 IF5_HUMAN 2.00E-105 GO:0005525; GO:0003924; GO:0005829; GO:0006446; GO:0003743 GTP binding; GTPase activity; cytosol; regulation of translational initiation; translation initiation factor activity IPR016024; IPR016021; IPR002735; IPR016189; IPR016190; IPR003307; Eukaryotic translation initiation factor 5 (eIF-5) EIF5 Homo sapiens (Human) TR41784_c1_g1_i1 Q12718 LAC2_TRAVE 6.00E-30 GO:0005507; GO:0005576; GO:0052716; GO:0046274 copper ion binding; extracellular region; hydroquinone:oxygen oxidoreductase activity; lignin catabolic process IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; Laccase-2 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 2) (Diphenol oxidase 2) (Laccase I) (Urishiol oxidase 2) LCC2 LCCI Trametes versicolor (White-rot fungus) (Coriolus versicolor) TR41784_c1_g1_i2 Q01679 LAC1_PHLRA 7.00E-34 GO:0005507; GO:0005576; GO:0052716; GO:0046274 copper ion binding; extracellular region; hydroquinone:oxygen oxidoreductase activity; lignin catabolic process IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; Laccase (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase) (Diphenol oxidase) (Ligninolytic phenoloxidase) (Urishiol oxidase) LAC Phlebia radiata (White-rot fungus) TR41784_c1_g1_i3 Q12739 LAC2_PLEOS 4.00E-08 GO:0005507; GO:0005576; GO:0052716; GO:0046274 copper ion binding; extracellular region; hydroquinone:oxygen oxidoreductase activity; lignin catabolic process IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; Laccase-2 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 2) (Diphenol oxidase 2) (Urishiol oxidase 2) POX2 Pleurotus ostreatus (Oyster mushroom) (White-rot fungus) TR41784_c1_g1_i5 Q40588 ASO_TOBAC 3.00E-06 GO:0008447; GO:0005507; GO:0005576 L-ascorbate oxidase activity; copper ion binding; extracellular region IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; IPR017760; L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) AAO Nicotiana tabacum (Common tobacco) TR41784_c1_g4_i2 Q96WT3 FET3_CANGA 7.00E-11 GO:0005507; GO:0016021; GO:0006811; GO:0055072; GO:0016491; GO:0005886 copper ion binding; integral to membrane; ion transport; iron ion homeostasis; oxidoreductase activity; plasma membrane IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; Iron transport multicopper oxidase FET3 (EC 1.-.-.-) FET3 CAGL0F06413g Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) TR41784_c1_g4_i4 Q9LYQ2 LAC13_ARATH 5.00E-12 GO:0048046; GO:0005507; GO:0052716; GO:0046274 apoplast; copper ion binding; hydroquinone:oxygen oxidoreductase activity; lignin catabolic process IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; IPR017761; Laccase-13 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 13) (Diphenol oxidase 13) (Urishiol oxidase 13) LAC13 At5g07130 T28J14.70 Arabidopsis thaliana (Mouse-ear cress) TR41784_c1_g4_i5 O80434 LAC4_ARATH 1.00E-11 GO:0048046; GO:0005507; GO:0052716; GO:0009809; GO:0046274; GO:0016491; GO:0009834 apoplast; copper ion binding; hydroquinone:oxygen oxidoreductase activity; lignin biosynthetic process; lignin catabolic process; oxidoreductase activity; secondary cell wall biogenesis IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; IPR017761; Laccase-4 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 4) (Diphenol oxidase 4) (Protein IRREGULAR XYLEM 12) (Urishiol oxidase 4) IRX12 LAC4 At2g38080 F16M14.1 Arabidopsis thaliana (Mouse-ear cress) TR41784_c1_g4_i6 Q0DHL5 LAC11_ORYSJ 2.00E-11 GO:0048046; GO:0005507; GO:0052716; GO:0046274 apoplast; copper ion binding; hydroquinone:oxygen oxidoreductase activity; lignin catabolic process IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; IPR017761; Putative laccase-11 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 11) (Diphenol oxidase 11) (Urishiol oxidase 11) LAC11 Os05g0458300 LOC_Os05g38390 OsJ_018044 Oryza sativa subsp. japonica (Rice) TR41784_c1_g4_i7 Q2QYS3 LAC23_ORYSJ 2.00E-11 GO:0048046; GO:0005507; GO:0052716; GO:0046274 apoplast; copper ion binding; hydroquinone:oxygen oxidoreductase activity; lignin catabolic process IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; IPR017761; Laccase-23 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 23) (Diphenol oxidase 23) (Urishiol oxidase 23) LAC23 Os12g0108000 LOC_Os12g01730 Oryza sativa subsp. japonica (Rice) TR41786_c0_g1_i1 A0JPQ7 CS047_RAT 3.00E-28 IPR013761; Uncharacterized protein C19orf47 homolog Rattus norvegicus (Rat) TR41786_c0_g1_i2 Q8N9M1 CS047_HUMAN 3.00E-27 IPR013761; Uncharacterized protein C19orf47 C19orf47 Homo sapiens (Human) TR41786_c0_g1_i3 A0JPQ7 CS047_RAT 3.00E-28 IPR013761; Uncharacterized protein C19orf47 homolog Rattus norvegicus (Rat) TR41787_c2_g1_i1 Q9Y5B6 GCFC1_HUMAN 6.00E-123 GO:0003677; GO:0005829; GO:0007517; GO:0005634; GO:0031062; GO:2000288; GO:0045944; GO:0014842; GO:0006355; GO:0003700; GO:0006351 "DNA binding; cytosol; muscle organ development; nucleus; positive regulation of histone methylation; positive regulation of myoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of satellite cell proliferation; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR012890; IPR022783; PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) PAXBP1 C21orf66 GCFC GCFC1 Homo sapiens (Human) TR41787_c2_g1_i13 Q9Y5B6 GCFC1_HUMAN 1.00E-148 GO:0003677; GO:0005829; GO:0007517; GO:0005634; GO:0031062; GO:2000288; GO:0045944; GO:0014842; GO:0006355; GO:0003700; GO:0006351 "DNA binding; cytosol; muscle organ development; nucleus; positive regulation of histone methylation; positive regulation of myoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of satellite cell proliferation; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR012890; IPR022783; PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) PAXBP1 C21orf66 GCFC GCFC1 Homo sapiens (Human) TR41787_c2_g1_i3 P16383 GCFC2_HUMAN 8.00E-73 GO:0003677; GO:0045892; GO:0005634; GO:0003700; GO:0006351 "DNA binding; negative regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR012890; IPR022783; GC-rich sequence DNA-binding factor 2 (GC-rich sequence DNA-binding factor) (Transcription factor 9) (TCF-9) GCFC2 C2orf3 GCF TCF9 Homo sapiens (Human) TR41787_c2_g1_i5 Q9Y5B6 GCFC1_HUMAN 6.00E-149 GO:0003677; GO:0005829; GO:0007517; GO:0005634; GO:0031062; GO:2000288; GO:0045944; GO:0014842; GO:0006355; GO:0003700; GO:0006351 "DNA binding; cytosol; muscle organ development; nucleus; positive regulation of histone methylation; positive regulation of myoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of satellite cell proliferation; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR012890; IPR022783; PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) PAXBP1 C21orf66 GCFC GCFC1 Homo sapiens (Human) TR41789_c0_g2_i1 Q80YG3 KLDC1_MOUSE 1.00E-46 GO:0005737 cytoplasm IPR011043; IPR015915; Kelch domain-containing protein 1 Klhdc1 Mus musculus (Mouse) TR41789_c0_g2_i2 Q9MA55 ACBP4_ARATH 5.00E-14 GO:0005737; GO:0005829; GO:0000062; GO:0008289; GO:0006869; GO:0005634; GO:0009723; GO:0009753; GO:0009416; GO:0006810 P42736 cytoplasm; cytosol; fatty-acyl-CoA binding; lipid binding; lipid transport; nucleus; response to ethylene stimulus; response to jasmonic acid stimulus; response to light stimulus; transport IPR000582; IPR014352; IPR015915; IPR011498; Acyl-CoA-binding domain-containing protein 4 (Acyl-CoA binding protein 4) ACBP4 At3g05420 F22F7.13 Arabidopsis thaliana (Mouse-ear cress) TR41789_c0_g4_i1 Q9C8K7 FBK21_ARATH 7.00E-06 IPR001810; IPR015916; IPR015915; F-box/kelch-repeat protein At1g51550 At1g51550 F5D21.4 Arabidopsis thaliana (Mouse-ear cress) TR41791_c0_g3_i1 Q6DFV5 HELZ_MOUSE 2.00E-93 GO:0005524; GO:0004386; GO:0046872; GO:0005634 ATP binding; helicase activity; metal ion binding; nucleus IPR027417; IPR000571; Probable helicase with zinc finger domain (EC 3.6.4.-) Helz Kiaa0054 Mus musculus (Mouse) TR41791_c0_g7_i2 Q57568 Y104_METJA 9.00E-09 GO:0005524; GO:0003677; GO:0004386 ATP binding; DNA binding; helicase activity IPR004483; IPR014001; IPR027417; Uncharacterized ATP-dependent helicase MJ0104 (EC 3.6.4.-) MJ0104 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR41791_c0_g7_i3 Q6NYU2 HELZ_DANRE 1.00E-154 GO:0005524; GO:0004386; GO:0046872; GO:0005634; GO:0003700 ATP binding; helicase activity; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity IPR027417; IPR011539; IPR000571; Probable helicase with zinc finger domain (EC 3.6.4.-) helz zgc:77407 Danio rerio (Zebrafish) (Brachydanio rerio) TR41791_c0_g8_i1 Q9UGR2 Z3H7B_HUMAN 5.00E-08 GO:0046872; GO:0019048; GO:0005634 Q00721 metal ion binding; modulation by virus of host morphology or physiology; nucleus IPR013026; IPR011990; IPR019734; IPR015880; IPR000571; Zinc finger CCCH domain-containing protein 7B (Rotavirus 'X'-associated non-structural protein) (RoXaN) ZC3H7B KIAA1031 Homo sapiens (Human) TR41792_c0_g2_i1 Q9NWK9 BCD1_HUMAN 4.00E-22 GO:0000492; GO:0046872; GO:0070761; GO:0042254 Q9UHK0 box C/D snoRNP assembly; metal ion binding; pre-snoRNP complex; ribosome biogenesis IPR007529; Box C/D snoRNA protein 1 (Serologically defined breast cancer antigen NY-BR-75) (Zinc finger HIT domain-containing protein 6) ZNHIT6 BCD1 C1orf181 Homo sapiens (Human) TR41792_c1_g1_i1 Q3TJZ6 FA98A_MOUSE 1.00E-20 IPR018797; Protein FAM98A Fam98a Mus musculus (Mouse) TR41792_c1_g1_i2 Q5FWT1 FA98A_RAT 1.00E-60 IPR018797; Protein FAM98A Fam98a Rattus norvegicus (Rat) TR41793_c0_g1_i1 Q8TDD1 DDX54_HUMAN 0 GO:0005524; GO:0004004; GO:0003723; GO:0006396; GO:0030331; GO:0030520; GO:0005730; GO:0006355; GO:0003714; GO:0006351 "ATP binding; ATP-dependent RNA helicase activity; RNA binding; RNA processing; estrogen receptor binding; intracellular estrogen receptor signaling pathway; nucleolus; regulation of transcription, DNA-dependent; transcription corepressor activity; transcription, DNA-dependent" IPR012541; IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) DDX54 Homo sapiens (Human) TR41793_c0_g1_i2 Q54CD8 DDX54_DICDI 2.00E-167 GO:0005524; GO:0008026; GO:0003723; GO:0005730; GO:0006364 ATP binding; ATP-dependent helicase activity; RNA binding; nucleolus; rRNA processing IPR012541; IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase ddx54 (EC 3.6.4.13) (ATP-dependent RNA helicase helA) (DEAD box protein 54) helA ddx54 DDB_G0292992 Dictyostelium discoideum (Slime mold) TR41793_c0_g4_i1 Q8K4L0 DDX54_MOUSE 2.00E-80 GO:0005524; GO:0004004; GO:0003723; GO:0006396; GO:0030331; GO:0005730; GO:0006355; GO:0003714; GO:0006351 "ATP binding; ATP-dependent RNA helicase activity; RNA binding; RNA processing; estrogen receptor binding; nucleolus; regulation of transcription, DNA-dependent; transcription corepressor activity; transcription, DNA-dependent" IPR012541; IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (DEAD box protein 54) Ddx54 Mus musculus (Mouse) TR41795_c0_g1_i2 Q54LJ3 TS101_DICDI 6.00E-07 GO:0000813; GO:0006464; GO:0031902; GO:0005634; GO:0015031; GO:0040008; GO:0030587 ESCRT I complex; cellular protein modification process; late endosome membrane; nucleus; protein transport; regulation of growth; sorocarp development IPR017916; IPR016135; IPR008883; ESCRT-I complex subunit tsg101 tsg101 DDB_G0286797 Dictyostelium discoideum (Slime mold) TR41795_c0_g2_i2 Q9LHG8 ELC_ARATH 3.00E-24 GO:0000813; GO:0051301; GO:0006464; GO:0005769; GO:0005770; GO:0015031; GO:0010091; GO:0043130 Q9FFY6; Q9FF81; Q9SCP9 ESCRT I complex; cell division; cellular protein modification process; early endosome; late endosome; protein transport; trichome branching; ubiquitin binding IPR017916; IPR016135; IPR008883; Protein ELC (AtELC) (ESCRT-I complex subunit VPS23 homolog 1) (Vacuolar protein-sorting-associated protein 23 homolog 1) ELC ELCH At3g12400 T2E22.28 Arabidopsis thaliana (Mouse-ear cress) TR41795_c0_g2_i3 Q66KB7 UEVLD_XENTR 1.00E-36 GO:0044262; GO:0006464; GO:0016616; GO:0015031 "cellular carbohydrate metabolic process; cellular protein modification process; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein transport" IPR001557; IPR022383; IPR001236; IPR015955; IPR016040; IPR016135; IPR008883; Ubiquitin-conjugating enzyme E2 variant 3 (UEV-3) (EV and lactate/malate dehydrogenase domain-containing protein) uevld uev3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41795_c0_g2_i4 Q6IRE4 TS101_RAT 5.00E-59 GO:0000813; GO:0007049; GO:0051301; GO:0008333; GO:0031902; GO:0030374; GO:0005634; GO:0006513; GO:0015031; GO:0040008; GO:0043162; GO:0046755 ESCRT I complex; cell cycle; cell division; endosome to lysosome transport; late endosome membrane; ligand-dependent nuclear receptor transcription coactivator activity; nucleus; protein monoubiquitination; protein transport; regulation of growth; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; viral budding IPR017916; IPR016135; IPR008883; Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) Tsg101 Rattus norvegicus (Rat) TR41796_c0_g6_i1 Q6DIC0 SMCA2_MOUSE 0 GO:0005524; GO:0001105; GO:0016514; GO:0071778; GO:0035887; GO:0004386; GO:0071565; GO:0030308; GO:0008285; GO:0045892; GO:0007399; GO:0071564; GO:0000790; GO:0006334; GO:0044212 "ATP binding; RNA polymerase II transcription coactivator activity; SWI/SNF complex; WINAC complex; aortic smooth muscle cell differentiation; helicase activity; nBAF complex; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; nervous system development; npBAF complex; nuclear chromatin; nucleosome assembly; transcription regulatory region DNA binding" IPR006576; IPR001487; IPR018359; IPR014978; IPR013999; IPR014012; IPR014001; IPR001650; IPR027417; IPR000330; Probable global transcription activator SNF2L2 (EC 3.6.4.-) (ATP-dependent helicase SMARCA2) (BRG1-associated factor 190B) (BAF190B) (Protein brahma homolog) (SNF2-alpha) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2) Smarca2 Baf190b Brm Snf2a Snf2l2 Mus musculus (Mouse) TR41796_c0_g6_i2 Q3TKT4 SMCA4_MOUSE 0 GO:0005524; GO:0016887; GO:0010424; GO:0008094; GO:0000977; GO:0001105; GO:0016514; GO:0071778; GO:0035887; GO:0001832; GO:0001835; GO:0000902; GO:0003682; GO:0006338; GO:0060318; GO:0035116; GO:0048562; GO:0048730; GO:0030198; GO:0030900; GO:0007403; GO:0060347; GO:0004386; GO:0000792; GO:0030902; GO:0043966; GO:0030216; GO:0001889; GO:0006346; GO:0071565; GO:0060766; GO:0030308; GO:0000122; GO:0003407; GO:0071564; GO:0005719; GO:0006334; GO:0006337; GO:0005726; GO:0043923; GO:0043388; GO:0051091; GO:0045944; GO:0019827; GO:0003714; GO:0001570 P06400; P13405; P97496; Q6P9Z1 ATP binding; ATPase activity; DNA methylation on cytosine within a CG sequence; DNA-dependent ATPase activity; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription coactivator activity; SWI/SNF complex; WINAC complex; aortic smooth muscle cell differentiation; blastocyst growth; blastocyst hatching; cell morphogenesis; chromatin binding; chromatin remodeling; definitive erythrocyte differentiation; embryonic hindlimb morphogenesis; embryonic organ morphogenesis; epidermis morphogenesis; extracellular matrix organization; forebrain development; glial cell fate determination; heart trabecula formation; helicase activity; heterochromatin; hindbrain development; histone H3 acetylation; keratinocyte differentiation; liver development; methylation-dependent chromatin silencing; nBAF complex; negative regulation of androgen receptor signaling pathway; negative regulation of cell growth; negative regulation of transcription from RNA polymerase II promoter; neural retina development; npBAF complex; nuclear euchromatin; nucleosome assembly; nucleosome disassembly; perichromatin fibrils; positive regulation by host of viral transcription; positive regulation of DNA binding; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; stem cell maintenance; transcription corepressor activity; vasculogenesis IPR006576; IPR001487; IPR018359; IPR014978; IPR013999; IPR014012; IPR014001; IPR001650; IPR027417; IPR000330; Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4) Smarca4 Baf190a Brg1 Snf2b Snf2l4 Mus musculus (Mouse) TR41796_c0_g6_i3 Q6DIC0 SMCA2_MOUSE 0 GO:0005524; GO:0001105; GO:0016514; GO:0071778; GO:0035887; GO:0004386; GO:0071565; GO:0030308; GO:0008285; GO:0045892; GO:0007399; GO:0071564; GO:0000790; GO:0006334; GO:0044212 "ATP binding; RNA polymerase II transcription coactivator activity; SWI/SNF complex; WINAC complex; aortic smooth muscle cell differentiation; helicase activity; nBAF complex; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; nervous system development; npBAF complex; nuclear chromatin; nucleosome assembly; transcription regulatory region DNA binding" IPR006576; IPR001487; IPR018359; IPR014978; IPR013999; IPR014012; IPR014001; IPR001650; IPR027417; IPR000330; Probable global transcription activator SNF2L2 (EC 3.6.4.-) (ATP-dependent helicase SMARCA2) (BRG1-associated factor 190B) (BAF190B) (Protein brahma homolog) (SNF2-alpha) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2) Smarca2 Baf190b Brm Snf2a Snf2l2 Mus musculus (Mouse) TR41796_c0_g6_i4 Q6DIC0 SMCA2_MOUSE 0 GO:0005524; GO:0001105; GO:0016514; GO:0071778; GO:0035887; GO:0004386; GO:0071565; GO:0030308; GO:0008285; GO:0045892; GO:0007399; GO:0071564; GO:0000790; GO:0006334; GO:0044212 "ATP binding; RNA polymerase II transcription coactivator activity; SWI/SNF complex; WINAC complex; aortic smooth muscle cell differentiation; helicase activity; nBAF complex; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; nervous system development; npBAF complex; nuclear chromatin; nucleosome assembly; transcription regulatory region DNA binding" IPR006576; IPR001487; IPR018359; IPR014978; IPR013999; IPR014012; IPR014001; IPR001650; IPR027417; IPR000330; Probable global transcription activator SNF2L2 (EC 3.6.4.-) (ATP-dependent helicase SMARCA2) (BRG1-associated factor 190B) (BAF190B) (Protein brahma homolog) (SNF2-alpha) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2) Smarca2 Baf190b Brm Snf2a Snf2l2 Mus musculus (Mouse) TR41799_c2_g1_i1 Q96KG7 MEG10_HUMAN 2.00E-50 GO:0016323; GO:0042995; GO:0034109; GO:0016021; GO:0055001; GO:0001891; GO:0043654; GO:0051147; GO:0048641; GO:0014719; GO:0014816; GO:0014841 basolateral plasma membrane; cell projection; homotypic cell-cell adhesion; integral to membrane; muscle cell development; phagocytic cup; recognition of apoptotic cell; regulation of muscle cell differentiation; regulation of skeletal muscle tissue development; satellite cell activation; satellite cell differentiation; satellite cell proliferation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) TR41799_c2_g1_i2 Q6DIB5 MEG10_MOUSE 6.00E-51 GO:0016323; GO:0042995; GO:0034109; GO:0016021; GO:0055001; GO:0001891; GO:0043654; GO:0051147; GO:0048641; GO:0014719; GO:0014816; GO:0014841 basolateral plasma membrane; cell projection; homotypic cell-cell adhesion; integral to membrane; muscle cell development; phagocytic cup; recognition of apoptotic cell; regulation of muscle cell differentiation; regulation of skeletal muscle tissue development; satellite cell activation; satellite cell differentiation; satellite cell proliferation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) TR41799_c2_g1_i3 Q80V70 MEGF6_MOUSE 3.00E-25 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR013111; IPR002049; IPR011489; IPR009030; Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) TR41801_c0_g1_i1 A1B049 KAD_PARDP 1.00E-11 GO:0044209; GO:0005524; GO:0004017; GO:0005737; GO:0008270 AMP salvage; ATP binding; adenylate kinase activity; cytoplasm; zinc ion binding IPR006259; IPR000850; IPR007862; IPR027417; Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1. Adenylate kinase (AK) (EC 2.7.4.3) (ATP-AMP transphosphorylase) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) adk Pden_0781 Paracoccus denitrificans (strain Pd 1222) TR41801_c3_g1_i1 P03354 POL_RSVP 9.00E-06 GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0075713; GO:0090305; GO:0006508; GO:0004523; GO:0005198; GO:0046718; GO:0019013; GO:0008270 DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; establishment of integrated proviral latency; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; structural molecule activity; viral entry into host cell; viral nucleocapsid; zinc ion binding IPR001969; IPR004028; IPR000721; IPR001037; IPR001584; IPR017856; IPR003308; IPR012344; IPR018061; IPR001995; IPR021109; IPR008916; IPR008919; IPR010999; IPR012337; IPR002156; IPR000477; IPR001878; Gag-Pro-Pol polyprotein [Cleaved into: Matrix protein p19; p2A; p2B; p10; Capsid protein p27; p3; Nucleocapsid protein p12; Protease p15 (EC 3.4.23.-); Reverse transcriptase beta-subunit (RT-beta) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Reverse transcriptase alpha-subunit (RT-alpha) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (pp32); p4] gag-pro-pol Rous sarcoma virus (strain Prague C) (RSV-PrC) TR41801_c3_g1_i2 Q6NY98 MCE1_DANRE 0 GO:0006370; GO:0005525; GO:0004484; GO:0005634; GO:0035335; GO:0098507; GO:0004651; GO:0004725; GO:0008138 7-methylguanosine mRNA capping; GTP binding; mRNA guanylyltransferase activity; nucleus; peptidyl-tyrosine dephosphorylation; polynucleotide 5' dephosphorylation; polynucleotide 5'-phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR017074; IPR001339; IPR013846; IPR012340; IPR000387; IPR016130; mRNA-capping enzyme [Includes: Polynucleotide 5'-triphosphatase (TPase) (mRNA 5'-triphosphatase) (EC 3.1.3.33); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)] rngtt si:ch211-241P10.5 zgc:76886 Danio rerio (Zebrafish) (Brachydanio rerio) TR41801_c3_g1_i3 Q04832 HEXP_LEIMA 3.00E-18 GO:0003677; GO:0005634; GO:0008270 DNA binding; nucleus; zinc ion binding IPR001878; DNA-binding protein HEXBP (Hexamer-binding protein) HEXBP Leishmania major TR41801_c3_g3_i2 Q5TCS8 AKD1_HUMAN 6.00E-44 GO:0006757; GO:0006756; GO:0005524; GO:0061508; GO:0061566; GO:0061568; GO:0061571; GO:0061569; GO:0005737; GO:0006174; GO:0061565; GO:0061570; GO:0061567; GO:0006186; GO:0004550; GO:0050145; GO:0017111; GO:0005634 ADP phosphorylation; AMP phosphorylation; ATP binding; CDP phosphorylation; CMP phosphorylation; GDP phosphorylation; TDP phosphorylation; UDP phosphorylation; cytoplasm; dADP phosphorylation; dAMP phosphorylation; dCDP phosphorylation; dCMP phosphorylation; dGDP phosphorylation; nucleoside diphosphate kinase activity; nucleoside phosphate kinase activity; nucleoside-triphosphatase activity; nucleus IPR003593; IPR000850; IPR027417; IPR007029; Adenylate kinase 9 (AK 9) (EC 2.7.4.4) (EC 2.7.4.6) (Adenylate kinase domain-containing protein 1) (Adenylate kinase domain-containing protein 2) AK9 AKD1 AKD2 C6orf199 C6orf224 Homo sapiens (Human) TR41801_c3_g3_i3 Q5TCS8 AKD1_HUMAN 1.00E-42 GO:0006757; GO:0006756; GO:0005524; GO:0061508; GO:0061566; GO:0061568; GO:0061571; GO:0061569; GO:0005737; GO:0006174; GO:0061565; GO:0061570; GO:0061567; GO:0006186; GO:0004550; GO:0050145; GO:0017111; GO:0005634 ADP phosphorylation; AMP phosphorylation; ATP binding; CDP phosphorylation; CMP phosphorylation; GDP phosphorylation; TDP phosphorylation; UDP phosphorylation; cytoplasm; dADP phosphorylation; dAMP phosphorylation; dCDP phosphorylation; dCMP phosphorylation; dGDP phosphorylation; nucleoside diphosphate kinase activity; nucleoside phosphate kinase activity; nucleoside-triphosphatase activity; nucleus IPR003593; IPR000850; IPR027417; IPR007029; Adenylate kinase 9 (AK 9) (EC 2.7.4.4) (EC 2.7.4.6) (Adenylate kinase domain-containing protein 1) (Adenylate kinase domain-containing protein 2) AK9 AKD1 AKD2 C6orf199 C6orf224 Homo sapiens (Human) TR41802_c0_g1_i1 Q9HAV4 XPO5_HUMAN 8.00E-157 GO:0003723; GO:0005829; GO:0010467; GO:0031047; GO:0005654; GO:0006611; GO:0008565; GO:0000049 RNA binding; cytosol; gene expression; gene silencing by RNA; nucleoplasm; protein export from nucleus; protein transporter activity; tRNA binding IPR011989; IPR016024; IPR013598; IPR001494; Exportin-5 (Exp5) (Ran-binding protein 21) XPO5 KIAA1291 RANBP21 Homo sapiens (Human) TR41802_c0_g2_i1 Q9HAV4 XPO5_HUMAN 3.00E-91 GO:0003723; GO:0005829; GO:0010467; GO:0031047; GO:0005654; GO:0006611; GO:0008565; GO:0000049 RNA binding; cytosol; gene expression; gene silencing by RNA; nucleoplasm; protein export from nucleus; protein transporter activity; tRNA binding IPR011989; IPR016024; IPR013598; IPR001494; Exportin-5 (Exp5) (Ran-binding protein 21) XPO5 KIAA1291 RANBP21 Homo sapiens (Human) TR41803_c6_g3_i1 P23508 CRCM_HUMAN 4.00E-109 GO:0016055; GO:0005737; GO:0090090; GO:0010633; GO:0050680; GO:0005634; GO:0005886; GO:0004872; GO:0007165 P29084; Q14160 Wnt receptor signaling pathway; cytoplasm; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of epithelial cell migration; negative regulation of epithelial cell proliferation; nucleus; plasma membrane; receptor activity; signal transduction IPR019536; Colorectal mutant cancer protein (Protein MCC) MCC Homo sapiens (Human) TR41803_c6_g3_i3 P23508 CRCM_HUMAN 1.00E-119 GO:0016055; GO:0005737; GO:0090090; GO:0010633; GO:0050680; GO:0005634; GO:0005886; GO:0004872; GO:0007165 P29084; Q14160 Wnt receptor signaling pathway; cytoplasm; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of epithelial cell migration; negative regulation of epithelial cell proliferation; nucleus; plasma membrane; receptor activity; signal transduction IPR019536; Colorectal mutant cancer protein (Protein MCC) MCC Homo sapiens (Human) TR41804_c0_g1_i1 Q9BQG1 SYT3_HUMAN 2.00E-72 GO:0005544; GO:0030054; GO:0005768; GO:0016021; GO:0046872; GO:0030672; GO:0005215 calcium-dependent phospholipid binding; cell junction; endosome; integral to membrane; metal ion binding; synaptic vesicle membrane; transporter activity IPR000008; IPR001565; Synaptotagmin-3 (Synaptotagmin III) (SytIII) SYT3 Homo sapiens (Human) TR41804_c0_g1_i12 P41823 SY65_APLCA 0 GO:0000149; GO:0005509; GO:0030054; GO:0030285; GO:0045955; GO:0016079; GO:0005215 SNARE binding; calcium ion binding; cell junction; integral to synaptic vesicle membrane; negative regulation of calcium ion-dependent exocytosis; synaptic vesicle exocytosis; transporter activity IPR000008; IPR001565; Synaptotagmin-1 (Synaptotagmin I) (p65) SYT1 Aplysia californica (California sea hare) TR41804_c0_g1_i3 P41823 SY65_APLCA 0 GO:0000149; GO:0005509; GO:0030054; GO:0030285; GO:0045955; GO:0016079; GO:0005215 SNARE binding; calcium ion binding; cell junction; integral to synaptic vesicle membrane; negative regulation of calcium ion-dependent exocytosis; synaptic vesicle exocytosis; transporter activity IPR000008; IPR001565; Synaptotagmin-1 (Synaptotagmin I) (p65) SYT1 Aplysia californica (California sea hare) TR41804_c0_g1_i6 P41823 SY65_APLCA 0 GO:0000149; GO:0005509; GO:0030054; GO:0030285; GO:0045955; GO:0016079; GO:0005215 SNARE binding; calcium ion binding; cell junction; integral to synaptic vesicle membrane; negative regulation of calcium ion-dependent exocytosis; synaptic vesicle exocytosis; transporter activity IPR000008; IPR001565; Synaptotagmin-1 (Synaptotagmin I) (p65) SYT1 Aplysia californica (California sea hare) TR41805_c1_g1_i1 Q2XWK0 SVOP_XENLA 7.00E-61 GO:0030054; GO:0016021; GO:0030672; GO:0022857 cell junction; integral to membrane; synaptic vesicle membrane; transmembrane transporter activity IPR011701; IPR020846; IPR016196; IPR005828; Synaptic vesicle 2-related protein (SV2-related protein) svop Xenopus laevis (African clawed frog) TR41805_c4_g2_i1 P30638 YOU1_CAEEL 3.00E-41 GO:0016021; GO:0015075 integral to membrane; ion transmembrane transporter activity IPR020846; IPR016196; IPR004749; IPR005828; Putative transporter ZK637.1 ZK637.1 Caenorhabditis elegans TR41805_c5_g2_i1 Q98880 ACHA_DANRE 5.00E-10 GO:0004889; GO:0005892; GO:0005261; GO:0030054; GO:0003428; GO:0086009; GO:0008045; GO:0007274; GO:0045211; GO:0043113; GO:0030516; GO:0048741; GO:0007271 "acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cation channel activity; cell junction; chondrocyte intercalation involved in growth plate cartilage morphogenesis; membrane repolarization; motor neuron axon guidance; neuromuscular synaptic transmission; postsynaptic membrane; receptor clustering; regulation of axon extension; skeletal muscle fiber development; synaptic transmission, cholinergic" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha chrna1 nic1 Danio rerio (Zebrafish) (Brachydanio rerio) TR41805_c6_g1_i1 Q1JP63 SVOP_BOVIN 4.00E-47 GO:0030054; GO:0016021; GO:0015075; GO:0030672 cell junction; integral to membrane; ion transmembrane transporter activity; synaptic vesicle membrane IPR011701; IPR020846; IPR016196; IPR004749; IPR005828; Synaptic vesicle 2-related protein (SV2-related protein) SVOP Bos taurus (Bovine) TR41806_c0_g3_i1 Q5T1M5 FKB15_HUMAN 2.00E-74 GO:0005884; GO:0030424; GO:0005769; GO:0006897; GO:0030426; GO:0010923; GO:0006457 actin filament; axon; early endosome; endocytosis; growth cone; negative regulation of phosphatase activity; protein folding IPR001179; FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP and FKBP-like) (WAFL) FKBP15 KIAA0674 Homo sapiens (Human) TR41806_c0_g3_i2 Q5T1M5 FKB15_HUMAN 2.00E-74 GO:0005884; GO:0030424; GO:0005769; GO:0006897; GO:0030426; GO:0010923; GO:0006457 actin filament; axon; early endosome; endocytosis; growth cone; negative regulation of phosphatase activity; protein folding IPR001179; FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP and FKBP-like) (WAFL) FKBP15 KIAA0674 Homo sapiens (Human) TR41807_c3_g3_i1 P61222 ABCE1_MOUSE 0 GO:0005524; GO:0006200; GO:0016887; GO:0051536; GO:0005739 ATP binding; ATP catabolic process; ATPase activity; iron-sulfur cluster binding; mitochondrion IPR001450; IPR017896; IPR017900; IPR003593; IPR013283; IPR003439; IPR017871; IPR027417; IPR007209; ATP-binding cassette sub-family E member 1 (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) Abce1 Rli Mus musculus (Mouse) TR41807_c3_g3_i2 Q9M0D0 AB3E_ARATH 2.00E-58 GO:0005524; GO:0006200; GO:0016887; GO:0005215 ATP binding; ATP catabolic process; ATPase activity; transporter activity IPR003593; IPR003439; IPR027417; ABC transporter E family member 3 (ABC transporter ABCE.3) (AtABCE3) (MRP-related protein 4) (Non-intrinsic ABC protein 15) (AtNAP15) (RNase L inhibitor-like protein 3) (AthaRLI3) ABCE3 NAP15 RLI3 At4g30300 F17I23.360 Arabidopsis thaliana (Mouse-ear cress) TR41807_c3_g3_i3 P61222 ABCE1_MOUSE 0 GO:0005524; GO:0006200; GO:0016887; GO:0051536; GO:0005739 ATP binding; ATP catabolic process; ATPase activity; iron-sulfur cluster binding; mitochondrion IPR001450; IPR017896; IPR017900; IPR003593; IPR013283; IPR003439; IPR017871; IPR027417; IPR007209; ATP-binding cassette sub-family E member 1 (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) Abce1 Rli Mus musculus (Mouse) TR41808_c1_g3_i1 Q2TBA3 MALT1_MOUSE 5.00E-20 GO:0001923; GO:0042098; GO:0050852; GO:0007250; GO:0004197; GO:0005829; GO:0045087; GO:0019209; GO:0051168; GO:0005634; GO:0048471; GO:0043123; GO:0051092; GO:0050870; GO:0002726; GO:0032743; GO:0043234; GO:0051259; GO:0006508; GO:0050856; GO:0042981; GO:0009620; GO:0002237; GO:0004871; GO:0004842 B-1 B cell differentiation; T cell proliferation; T cell receptor signaling pathway; activation of NF-kappaB-inducing kinase activity; cysteine-type endopeptidase activity; cytosol; innate immune response; kinase activator activity; nuclear export; nucleus; perinuclear region of cytoplasm; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell activation; positive regulation of T cell cytokine production; positive regulation of interleukin-2 production; protein complex; protein oligomerization; proteolysis; regulation of T cell receptor signaling pathway; regulation of apoptotic process; response to fungus; response to molecule of bacterial origin; signal transducer activity; ubiquitin-protein ligase activity IPR011029; IPR007110; IPR013783; IPR003598; IPR011600; IPR001309; Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog (EC 3.4.22.-) (Paracaspase) Malt1 Mus musculus (Mouse) TR41808_c1_g3_i4 Q9UDY8 MALT1_HUMAN 7.00E-21 GO:0001923; GO:0032449; GO:0038095; GO:0042098; GO:0050852; GO:0007250; GO:0004197; GO:0005829; GO:0045087; GO:0043066; GO:0051168; GO:0005634; GO:0048471; GO:0005886; GO:0043123; GO:0051092; GO:0050870; GO:0002726; GO:0032743; GO:0031398; GO:0051259; GO:0006508; GO:0050856; GO:0009620; GO:0002237; GO:0004871; GO:0004842 O95999; Q14790; Q9Y6K9; Q13501; Q9Y4K3; P0CG48 B-1 B cell differentiation; CBM complex; Fc-epsilon receptor signaling pathway; T cell proliferation; T cell receptor signaling pathway; activation of NF-kappaB-inducing kinase activity; cysteine-type endopeptidase activity; cytosol; innate immune response; negative regulation of apoptotic process; nuclear export; nucleus; perinuclear region of cytoplasm; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell activation; positive regulation of T cell cytokine production; positive regulation of interleukin-2 production; positive regulation of protein ubiquitination; protein oligomerization; proteolysis; regulation of T cell receptor signaling pathway; response to fungus; response to molecule of bacterial origin; signal transducer activity; ubiquitin-protein ligase activity IPR011029; IPR007110; IPR013783; IPR003599; IPR003598; IPR011600; IPR001309; Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase) MALT1 MLT Homo sapiens (Human) TR41809_c6_g1_i1 Q7ZYC4 ACBG2_XENLA 0 GO:0005524; GO:0005737; GO:0001676; GO:0004467 ATP binding; cytoplasm; long-chain fatty acid metabolic process; long-chain fatty acid-CoA ligase activity IPR020845; IPR000873; Long-chain-fatty-acid--CoA ligase ACSBG2 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 2) acsbg2 Xenopus laevis (African clawed frog) TR41811_c0_g1_i1 A6QLK6 GRAP_BOVIN 7.00E-11 IPR000108; IPR000980; IPR011511; IPR001452; GRB2-related adapter protein GRAP Bos taurus (Bovine) TR41811_c0_g1_i3 A1A5H8 YES_DANRE 3.00E-161 GO:0005524; GO:0060027; GO:0005829; GO:0005815; GO:0004715; GO:0005886; GO:0046777; GO:0004713; GO:0045859 ATP binding; convergent extension involved in gastrulation; cytosol; microtubule organizing center; non-membrane spanning protein tyrosine kinase activity; plasma membrane; protein autophosphorylation; protein tyrosine kinase activity; regulation of protein kinase activity IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase yes (EC 2.7.10.2) (p61-Yes) yes1 yes Danio rerio (Zebrafish) (Brachydanio rerio) TR41811_c0_g1_i5 Q8TC17 GRAPL_HUMAN 2.00E-09 IPR000980; IPR001452; GRB2-related adapter protein-like GRAPL Homo sapiens (Human) TR41811_c0_g1_i6 A1A5H8 YES_DANRE 2.00E-61 GO:0005524; GO:0060027; GO:0005829; GO:0005815; GO:0004715; GO:0005886; GO:0046777; GO:0004713; GO:0045859 ATP binding; convergent extension involved in gastrulation; cytosol; microtubule organizing center; non-membrane spanning protein tyrosine kinase activity; plasma membrane; protein autophosphorylation; protein tyrosine kinase activity; regulation of protein kinase activity IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase yes (EC 2.7.10.2) (p61-Yes) yes1 yes Danio rerio (Zebrafish) (Brachydanio rerio) TR41811_c0_g1_i8 Q8R4L0 SLAP2_MOUSE 2.00E-32 GO:0005070; GO:0042110; GO:0016023; GO:0005770; GO:0050849; GO:0000122; GO:0005886; GO:0047485 SH3/SH2 adaptor activity; T cell activation; cytoplasmic membrane-bounded vesicle; late endosome; negative regulation of calcium-mediated signaling; negative regulation of transcription from RNA polymerase II promoter; plasma membrane; protein N-terminus binding IPR000980; IPR001452; Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) Sla2 Mus musculus (Mouse) TR41813_c0_g1_i1 Q01989 MYS9_DROME 5.00E-73 GO:0005524; GO:0042623; GO:0051015; GO:0007015; GO:0030048; GO:0055059; GO:0045167; GO:0045178; GO:0045175; GO:0007298; GO:0005938; GO:0045217; GO:0019749; GO:0007391; GO:0030139; GO:0040001; GO:0045172; GO:0007560; GO:0070865; GO:0008363; GO:0061024; GO:0000146; GO:0005875; GO:0008017; GO:0047497; GO:0016333; GO:0031476; GO:0051647; GO:0006997; GO:0045921; GO:0030589; GO:0032956; GO:0032880; GO:0007291; GO:0030317; GO:0007051 "ATP binding; ATPase activity, coupled; actin filament binding; actin filament organization; actin filament-based movement; asymmetric neuroblast division; asymmetric protein localization involved in cell fate determination; basal part of cell; basal protein localization; border follicle cell migration; cell cortex; cell-cell junction maintenance; cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte; dorsal closure; endocytic vesicle; establishment of mitotic spindle localization; germline ring canal; imaginal disc morphogenesis; investment cone; larval chitin-based cuticle development; membrane organization; microfilament motor activity; microtubule associated complex; microtubule binding; mitochondrion transport along microtubule; morphogenesis of follicular epithelium; myosin VI complex; nucleus localization; nucleus organization; positive regulation of exocytosis; pseudocleavage involved in syncytial blastoderm formation; regulation of actin cytoskeleton organization; regulation of protein localization; sperm individualization; sperm motility; spindle organization" IPR000048; IPR001609; IPR004009; IPR027417; Myosin heavy chain 95F (95F MHC) (Protein jaguar) jar Mhc95F CG5695 Drosophila melanogaster (Fruit fly) TR41813_c2_g1_i1 A8PWF6 MYO1_MALGO 9.00E-32 GO:0005524; GO:0030479; GO:0003774; GO:0016459 ATP binding; actin cortical patch; motor activity; myosin complex IPR001609; IPR010926; IPR027417; IPR001452; Myosin-1 (Class I unconventional myosin) (Type I myosin) MYO1 MGL_1086 Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated fungus) TR41813_c3_g1_i5 Q9UM54 MYO6_HUMAN 4.00E-107 GO:0043531; GO:0005524; GO:0030330; GO:0016591; GO:0005794; GO:0051015; GO:0030048; GO:0042491; GO:0030424; GO:0005516; GO:0005938; GO:0071257; GO:0030665; GO:0005905; GO:0016023; GO:0005829; GO:0016358; GO:0006897; GO:0031941; GO:0014047; GO:0042472; GO:0006886; GO:0007626; GO:0005765; GO:0060001; GO:0043025; GO:0031965; GO:0048471; GO:0005886; GO:0045944; GO:0006605; GO:0051046; GO:0048167; GO:0001726; GO:0032587; GO:0007605; GO:0007416; GO:0007268; GO:0016461 P98082; P98078 "ADP binding; ATP binding; DNA damage response, signal transduction by p53 class mediator; DNA-directed RNA polymerase II, holoenzyme; Golgi apparatus; actin filament binding; actin filament-based movement; auditory receptor cell differentiation; axon; calmodulin binding; cell cortex; cellular response to electrical stimulus; clathrin-coated vesicle membrane; coated pit; cytoplasmic membrane-bounded vesicle; cytosol; dendrite development; endocytosis; filamentous actin; glutamate secretion; inner ear morphogenesis; intracellular protein transport; locomotory behavior; lysosomal membrane; minus-end directed microfilament motor activity; neuronal cell body; nuclear membrane; perinuclear region of cytoplasm; plasma membrane; positive regulation of transcription from RNA polymerase II promoter; protein targeting; regulation of secretion; regulation of synaptic plasticity; ruffle; ruffle membrane; sensory perception of sound; synapse assembly; synaptic transmission; unconventional myosin complex" IPR000048; IPR001609; IPR027417; Unconventional myosin-VI (Unconventional myosin-6) MYO6 KIAA0389 Homo sapiens (Human) TR41813_c3_g1_i7 Q29122 MYO6_PIG 7.00E-72 GO:0043531; GO:0005524; GO:0030330; GO:0016591; GO:0005794; GO:0051015; GO:0030048; GO:0005516; GO:0005938; GO:0016023; GO:0006897; GO:0031941; GO:0006886; GO:0003774; GO:0016459; GO:0031965; GO:0048471; GO:0045944; GO:0051046; GO:0001726; GO:0007605 "ADP binding; ATP binding; DNA damage response, signal transduction by p53 class mediator; DNA-directed RNA polymerase II, holoenzyme; Golgi apparatus; actin filament binding; actin filament-based movement; calmodulin binding; cell cortex; cytoplasmic membrane-bounded vesicle; endocytosis; filamentous actin; intracellular protein transport; motor activity; myosin complex; nuclear membrane; perinuclear region of cytoplasm; positive regulation of transcription from RNA polymerase II promoter; regulation of secretion; ruffle; sensory perception of sound" IPR000048; IPR001609; IPR027417; Unconventional myosin-VI (Unconventional myosin-6) MYO6 Sus scrofa (Pig) TR41816_c0_g1_i1 Q9NSE7 ABCCD_HUMAN 3.00E-08 GO:0005524; GO:0042626; GO:0016021; GO:0005634 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; nucleus" IPR011527; IPR001140; Putative ATP-binding cassette sub-family C member 13 ABCC13 C21orf73 PRED6 Homo sapiens (Human) TR41816_c1_g1_i1 P47261 Y015_MYCGE 2.00E-37 GO:0005524; GO:0006200; GO:0042626; GO:0016021; GO:0005886 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; plasma membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Putative ABC transporter ATP-binding protein MG015 MG015 Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) TR41816_c1_g1_i2 P18770 CYAB_BORPE 6.00E-38 TR41816_c1_g1_i3 Q864R9 MRP1_MACFA 0 GO:0005524; GO:0006200; GO:0042626; GO:0016021; GO:0005886 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; plasma membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR41816_c1_g1_i4 Q83J77 NIKE_SHIFL 7.00E-06 GO:0005524; GO:0006200; GO:0016151; GO:0015413; GO:0005886 ATP binding; ATP catabolic process; nickel cation binding; nickel-transporting ATPase activity; plasma membrane IPR003593; IPR003439; IPR017871; IPR015858; IPR014137; IPR027417; Nickel import ATP-binding protein NikE (EC 3.6.3.24) nikE SF3498 S4265 Shigella flexneri TR41816_c1_g1_i5 Q864R9 MRP1_MACFA 0 GO:0005524; GO:0006200; GO:0042626; GO:0016021; GO:0005886 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; plasma membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR41817_c0_g1_i4 Q5TYW4 NBAS_DANRE 1.00E-136 GO:0009790; GO:0000184 "embryo development; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" IPR013244; IPR015943; IPR001680; IPR017986; Neuroblastoma-amplified sequence (Neuroblastoma-amplified gene protein homolog) nbas nag si:ch211-214k9.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR41818_c1_g1_i1 A1L1C7 PAN3_XENTR 2.00E-124 GO:0005524; GO:0031251; GO:0006397; GO:0046872; GO:0004672 ATP binding; PAN complex; mRNA processing; metal ion binding; protein kinase activity IPR011009; IPR000719; IPR000571; PAB-dependent poly(A)-specific ribonuclease subunit 3 pan3 TEgg127h19.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41818_c1_g1_i4 Q640Q5 PAN3_MOUSE 6.00E-125 GO:0005524; GO:0031251; GO:0005813; GO:0000932; GO:0000290; GO:0046872; GO:0000184; GO:0004535; GO:0010606; GO:0004672; GO:0006605 "ATP binding; PAN complex; centrosome; cytoplasmic mRNA processing body; deadenylation-dependent decapping of nuclear-transcribed mRNA; metal ion binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; poly(A)-specific ribonuclease activity; positive regulation of cytoplasmic mRNA processing body assembly; protein kinase activity; protein targeting" IPR011009; IPR000719; IPR000571; PAB-dependent poly(A)-specific ribonuclease subunit 3 Pan3 Mus musculus (Mouse) TR41818_c1_g1_i6 Q640Q5 PAN3_MOUSE 5.00E-125 GO:0005524; GO:0031251; GO:0005813; GO:0000932; GO:0000290; GO:0046872; GO:0000184; GO:0004535; GO:0010606; GO:0004672; GO:0006605 "ATP binding; PAN complex; centrosome; cytoplasmic mRNA processing body; deadenylation-dependent decapping of nuclear-transcribed mRNA; metal ion binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; poly(A)-specific ribonuclease activity; positive regulation of cytoplasmic mRNA processing body assembly; protein kinase activity; protein targeting" IPR011009; IPR000719; IPR000571; PAB-dependent poly(A)-specific ribonuclease subunit 3 Pan3 Mus musculus (Mouse) TR41819_c0_g3_i1 A9BHK4 CH60_PETMO 5.00E-13 GO:0005524; GO:0005737; GO:0042026 ATP binding; cytoplasm; protein refolding IPR018370; IPR001844; IPR002423; IPR027409; IPR027413; 60 kDa chaperonin (GroEL protein) (Protein Cpn60) groL groEL Pmob_1158 Petrotoga mobilis (strain DSM 10674 / SJ95) TR41819_c0_g3_i2 P50991 TCPD_HUMAN 0 GO:0051084; GO:0005524; GO:0007339; GO:0005813; GO:0005832; GO:0005829; GO:0042470; GO:0005874; GO:0005634; GO:0051082; GO:0002199 'de novo' posttranslational protein folding; ATP binding; binding of sperm to zona pellucida; centrosome; chaperonin-containing T-complex; cytosol; melanosome; microtubule; nucleus; unfolded protein binding; zona pellucida receptor complex IPR012717; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (Stimulator of TAR RNA-binding) CCT4 CCTD SRB Homo sapiens (Human) TR4182_c0_g2_i1 A2A9C3 SZT2_MOUSE 6.00E-22 GO:0007417; GO:0005777; GO:0043473; GO:0009791 central nervous system development; peroxisome; pigmentation; post-embryonic development Protein SZT2 (Seizure threshold 2 protein) (Transcript increased in glutamate resistance) (TIGR) Szt2 Mus musculus (Mouse) TR41820_c2_g2_i5 Q6Y228 LTOR3_PAGMA 1.00E-36 GO:0071986; GO:0034613; GO:0071230; GO:0032008 Ragulator complex; cellular protein localization; cellular response to amino acid stimulus; positive regulation of TOR signaling cascade IPR015019; Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) lamtor3 Pagrus major (Red sea bream) (Chrysophrys major) TR41825_c0_g3_i1 Q8YTC2 Y2800_NOSS1 3.00E-38 GO:0043531; GO:0006952; GO:0006355 "ADP binding; defense response; regulation of transcription, DNA-dependent" IPR000767; IPR020472; IPR002182; IPR027417; IPR027728; IPR015943; IPR001680; IPR019775; IPR017986; Uncharacterized WD repeat-containing protein alr2800 alr2800 Nostoc sp. (strain PCC 7120 / UTEX 2576) TR41825_c0_g3_i2 Q9QXE7 TBL1X_MOUSE 0 GO:0003682; GO:0045444; GO:0045892; GO:0005654; GO:0045944; GO:0043161; GO:0043627; GO:0003714; GO:0005667; GO:0044212; GO:0006351 "chromatin binding; fat cell differentiation; negative regulation of transcription, DNA-dependent; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; response to estrogen stimulus; transcription corepressor activity; transcription factor complex; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR020472; IPR006594; IPR013720; IPR015943; IPR001680; IPR019775; IPR017986; F-box-like/WD repeat-containing protein TBL1X (Transducin beta-like protein 1X) Tbl1x Tbl1 Mus musculus (Mouse) TR41825_c0_g3_i3 Q95RJ9 EBI_DROME 0 GO:0005525; GO:0007219; GO:0007049; GO:0022416; GO:0003682; GO:0042676; GO:0007173; GO:0000122; GO:0042461; GO:0005700; GO:0045747; GO:0031065; GO:0045572; GO:0042058; GO:0030162; GO:0017053; GO:0007601; GO:0035220 Q9VNC2; Q27934; P21461; P08044; P42282 GTP binding; Notch signaling pathway; cell cycle; chaeta development; chromatin binding; compound eye cone cell fate commitment; epidermal growth factor receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; photoreceptor cell development; polytene chromosome; positive regulation of Notch signaling pathway; positive regulation of histone deacetylation; positive regulation of imaginal disc growth; regulation of epidermal growth factor receptor signaling pathway; regulation of proteolysis; transcriptional repressor complex; visual perception; wing disc development IPR020472; IPR006594; IPR013720; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; F-box-like/WD repeat-containing protein ebi ebi CG4063 Drosophila melanogaster (Fruit fly) TR41825_c0_g3_i4 Q9QXE7 TBL1X_MOUSE 0 GO:0003682; GO:0045444; GO:0045892; GO:0005654; GO:0045944; GO:0043161; GO:0043627; GO:0003714; GO:0005667; GO:0044212; GO:0006351 "chromatin binding; fat cell differentiation; negative regulation of transcription, DNA-dependent; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; response to estrogen stimulus; transcription corepressor activity; transcription factor complex; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR020472; IPR006594; IPR013720; IPR015943; IPR001680; IPR019775; IPR017986; F-box-like/WD repeat-containing protein TBL1X (Transducin beta-like protein 1X) Tbl1x Tbl1 Mus musculus (Mouse) TR41826_c4_g1_i1 Q99PV0 PRP8_MOUSE 0 GO:0030623; GO:0017070; GO:0071013; GO:0000398; GO:0016607 "U5 snRNA binding; U6 snRNA binding; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nuclear speck" IPR000555; IPR012591; IPR012592; IPR012984; IPR027652; IPR021983; IPR019581; IPR019580; IPR012337; IPR019582; Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8) Prpf8 Prp8 Mus musculus (Mouse) TR41826_c4_g2_i1 Q9QYE0 PLAG1_MOUSE 2.00E-43 GO:0003677; GO:0022612; GO:0046872; GO:0035264; GO:0010629; GO:0005634; GO:0035265; GO:0010628; GO:0060252; GO:0060736; GO:0000981 DNA binding; gland morphogenesis; metal ion binding; multicellular organism growth; negative regulation of gene expression; nucleus; organ growth; positive regulation of gene expression; positive regulation of glial cell proliferation; prostate gland growth; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR027765; IPR007087; IPR015880; IPR013087; Zinc finger protein PLAG1 (Pleiomorphic adenoma gene 1 protein) Plag1 Mus musculus (Mouse) TR41827_c3_g2_i10 C3YWU0 FUCO_BRAFL 4.00E-180 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR41827_c3_g2_i2 Q2KIM0 FUCO_BOVIN 3.00E-160 GO:0004560; GO:0042806; GO:0006004; GO:0005764 alpha-L-fucosidase activity; fucose binding; fucose metabolic process; lysosome IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) FUCA1 Bos taurus (Bovine) TR41827_c3_g2_i3 C3YWU0 FUCO_BRAFL 6.00E-166 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR41828_c2_g2_i1 P0CE10 Y4102_ARATH 1.00E-69 GO:0005524; GO:0008026; GO:0003723; GO:0009507; GO:0008270 ATP binding; ATP-dependent helicase activity; RNA binding; chloroplast; zinc ion binding IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR004087; IPR027417; IPR007087; IPR015880; IPR018957; IPR002867; IPR001841; IPR013083; IPR017907; "Putative uncharacterized protein At4g01020, chloroplastic" At4g01020 F3I3.40 Arabidopsis thaliana (Mouse-ear cress) TR41828_c3_g1_i1 P34498 MOG1_CAEEL 2.00E-46 GO:0005524; GO:0008026; GO:0008380; GO:0040022; GO:0006397; GO:0003676; GO:0005634 Q21502; O45244 ATP binding; ATP-dependent helicase activity; RNA splicing; feminization of hermaphroditic germ-line; mRNA processing; nucleic acid binding; nucleus IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 (EC 3.6.4.13) (Masculinization of germline protein 1) (Sex determination protein mog-1) mog-1 K03H1.2 Caenorhabditis elegans TR41828_c6_g1_i1 Q94981 ARI1_DROME 2.00E-18 GO:0005737; GO:0005634; GO:0042787; GO:0004842; GO:0008270 cytoplasm; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR018957; IPR002867; IPR001841; IPR013083; Protein ariadne-1 (Ari-1) ari-1 ari CG5659 Drosophila melanogaster (Fruit fly) TR41828_c6_g1_i2 P0CE10 Y4102_ARATH 5.00E-63 GO:0005524; GO:0008026; GO:0003723; GO:0009507; GO:0008270 ATP binding; ATP-dependent helicase activity; RNA binding; chloroplast; zinc ion binding IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR004087; IPR027417; IPR007087; IPR015880; IPR018957; IPR002867; IPR001841; IPR013083; IPR017907; "Putative uncharacterized protein At4g01020, chloroplastic" At4g01020 F3I3.40 Arabidopsis thaliana (Mouse-ear cress) TR41828_c7_g1_i1 P24384 PRP22_YEAST 2.00E-12 GO:0005524; GO:0004004; GO:0003723; GO:0071007; GO:0071021; GO:0000350; GO:0000390 ATP binding; ATP-dependent RNA helicase activity; RNA binding; U2-type catalytic step 2 spliceosome; U2-type post-spliceosomal complex; generation of catalytic spliceosome for second transesterification step; spliceosomal complex disassembly IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR012340; IPR027417; IPR003029; IPR022967; Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22 (EC 3.6.4.13) PRP22 YER013W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41829_c0_g1_i1 Q0VH32 MNT_XENLA 1.00E-41 GO:0003677; GO:0005634; GO:0006355; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011598; Max-binding protein MNT (Myc antagonist MNT) mnt Xenopus laevis (African clawed frog) TR41830_c2_g1_i1 Q8VY21 TLP3_ARATH 8.00E-41 IPR001810; IPR000007; IPR025659; Tubby-like F-box protein 3 (AtTLP3) TULP3 At2g47900 F17A22.29 Arabidopsis thaliana (Mouse-ear cress) TR41830_c2_g1_i2 P50607 TUB_HUMAN 6.00E-132 GO:0008020; GO:0005737; GO:0005829; GO:0005576; GO:0044259; GO:0005634; GO:0006909; GO:0007602; GO:0005886; GO:0050766; GO:0009725; GO:0060041; GO:0007605 G-protein coupled photoreceptor activity; cytoplasm; cytosol; extracellular region; multicellular organismal macromolecule metabolic process; nucleus; phagocytosis; phototransduction; plasma membrane; positive regulation of phagocytosis; response to hormone stimulus; retina development in camera-type eye; sensory perception of sound IPR000007; IPR025659; IPR018066; IPR005398; Tubby protein homolog TUB Homo sapiens (Human) TR41833_c0_g1_i1 Q9HBA9 FOH1B_HUMAN 3.00E-47 GO:0005737; GO:0016805; GO:0046872; GO:0008237; GO:0006508 cytoplasm; dipeptidase activity; metal ion binding; metallopeptidase activity; proteolysis IPR007484; IPR007365; Putative N-acetylated-alpha-linked acidic dipeptidase (NAALADase) (EC 3.4.-.-) (Cell growth-inhibiting gene 26 protein) (Prostate-specific membrane antigen-like protein) (Putative folate hydrolase 1B) FOLH1B PSMAL GIG26 Homo sapiens (Human) TR41833_c0_g3_i1 Q9Y3Q0 NALD2_HUMAN 9.00E-141 GO:0050129; GO:0004180; GO:0016805; GO:0008239; GO:0016021; GO:0046872; GO:0008237; GO:0042135; GO:0006508; GO:0008236 N-formylglutamate deformylase activity; carboxypeptidase activity; dipeptidase activity; dipeptidyl-peptidase activity; integral to membrane; metal ion binding; metallopeptidase activity; neurotransmitter catabolic process; proteolysis; serine-type peptidase activity IPR007484; IPR003137; IPR007365; N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) NAALAD2 Homo sapiens (Human) TR41834_c0_g2_i1 Q9Y4P3 TBL2_HUMAN 7.00E-125 IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Transducin beta-like protein 2 (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosomal region 13 protein) TBL2 WBSCR13 UNQ563/PRO1125 Homo sapiens (Human) TR41834_c0_g2_i3 Q00808 HETE1_PODAS 2.00E-15 GO:0005525 GTP binding IPR020472; IPR010730; IPR007111; IPR027417; IPR015943; IPR001680; IPR019775; IPR017986; Vegetative incompatibility protein HET-E-1 HET-E1 Podospora anserina (Pleurage anserina) TR41834_c0_g2_i4 Q00808 HETE1_PODAS 1.00E-15 GO:0005525 GTP binding IPR020472; IPR010730; IPR007111; IPR027417; IPR015943; IPR001680; IPR019775; IPR017986; Vegetative incompatibility protein HET-E-1 HET-E1 Podospora anserina (Pleurage anserina) TR41834_c0_g2_i5 Q9Y4P3 TBL2_HUMAN 1.00E-124 IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Transducin beta-like protein 2 (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosomal region 13 protein) TBL2 WBSCR13 UNQ563/PRO1125 Homo sapiens (Human) TR41835_c1_g1_i1 Q7PPA5 ATC1_ANOGA 0 GO:0005524; GO:0005388; GO:0016021; GO:0046872; GO:0033017 ATP binding; calcium-transporting ATPase activity; integral to membrane; metal ion binding; sarcoplasmic reticulum membrane IPR005782; IPR006068; IPR004014; IPR023299; IPR018303; IPR023298; IPR008250; IPR001757; IPR023214; Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type (EC 3.6.3.8) (Calcium pump) Ca-P60A AGAP006186 Anopheles gambiae (African malaria mosquito) TR41835_c1_g1_i3 Q7PPA5 ATC1_ANOGA 0 GO:0005524; GO:0005388; GO:0016021; GO:0046872; GO:0033017 ATP binding; calcium-transporting ATPase activity; integral to membrane; metal ion binding; sarcoplasmic reticulum membrane IPR005782; IPR006068; IPR004014; IPR023299; IPR018303; IPR023298; IPR008250; IPR001757; IPR023214; Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type (EC 3.6.3.8) (Calcium pump) Ca-P60A AGAP006186 Anopheles gambiae (African malaria mosquito) TR41836_c1_g1_i1 D3ZTX0 TMED7_RAT 1.00E-26 GO:0030663; GO:0012507; GO:0005794; GO:0005783; GO:0005789; GO:0005793; GO:0033116; GO:0016021; GO:0015031 COPI-coated vesicle membrane; ER to Golgi transport vesicle membrane; Golgi apparatus; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; protein transport IPR009038; IPR015718; Transmembrane emp24 domain-containing protein 7 (p24 family protein gamma-3) (p24gamma3) (p27) Tmed7 Rattus norvegicus (Rat) TR41836_c1_g3_i3 D3ZTX0 TMED7_RAT 2.00E-26 GO:0030663; GO:0012507; GO:0005794; GO:0005783; GO:0005789; GO:0005793; GO:0033116; GO:0016021; GO:0015031 COPI-coated vesicle membrane; ER to Golgi transport vesicle membrane; Golgi apparatus; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; protein transport IPR009038; IPR015718; Transmembrane emp24 domain-containing protein 7 (p24 family protein gamma-3) (p24gamma3) (p27) Tmed7 Rattus norvegicus (Rat) TR41836_c1_g3_i6 Q78IS1 TMED3_MOUSE 4.00E-26 GO:0030126; GO:0032580; GO:0005783; GO:0005789; GO:0005793; GO:0033116; GO:0016021; GO:0015031 COPI vesicle coat; Golgi cisterna membrane; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; integral to membrane; protein transport IPR009038; IPR015718; Transmembrane emp24 domain-containing protein 3 (p24 family protein gamma-4) (p24gamma4) Tmed3 Mus musculus (Mouse) TR41837_c1_g1_i1 Q9VR07 INE_DROME 6.00E-10 GO:0016021; GO:0005328; GO:0005034; GO:0042066; GO:0009881; GO:0005886; GO:0047484; GO:0019226 integral to membrane; neurotransmitter:sodium symporter activity; osmosensor activity; perineurial glial growth; photoreceptor activity; plasma membrane; regulation of response to osmotic stress; transmission of nerve impulse IPR000175; IPR002944; Sodium- and chloride-dependent GABA transporter ine (Protein inebriated) (Protein receptor oscillation A) ine rosA CG15444 Drosophila melanogaster (Fruit fly) TR41837_c1_g1_i10 Q9VR07 INE_DROME 2.00E-10 GO:0016021; GO:0005328; GO:0005034; GO:0042066; GO:0009881; GO:0005886; GO:0047484; GO:0019226 integral to membrane; neurotransmitter:sodium symporter activity; osmosensor activity; perineurial glial growth; photoreceptor activity; plasma membrane; regulation of response to osmotic stress; transmission of nerve impulse IPR000175; IPR002944; Sodium- and chloride-dependent GABA transporter ine (Protein inebriated) (Protein receptor oscillation A) ine rosA CG15444 Drosophila melanogaster (Fruit fly) TR41837_c1_g1_i3 P31652 SC6A4_RAT 2.00E-08 GO:0051015; GO:0007420; GO:0048854; GO:0071321; GO:0071300; GO:0007623; GO:0019811; GO:0005829; GO:0012505; GO:0010008; GO:0005887; GO:0007626; GO:0045121; GO:0007613; GO:0021941; GO:0045665; GO:0046621; GO:0032227; GO:0043005; GO:0005886; GO:0045787; GO:0010628; GO:0042803; GO:0051260; GO:0042493; GO:0032355; GO:0001666; GO:0007584; GO:0009636; GO:0051610; GO:0005335; GO:0035176; GO:0042713; GO:0021794; GO:0042310 "actin filament binding; brain development; brain morphogenesis; cellular response to cGMP; cellular response to retinoic acid; circadian rhythm; cocaine binding; cytosol; endomembrane system; endosome membrane; integral to plasma membrane; locomotory behavior; membrane raft; memory; negative regulation of cerebellar granule cell precursor proliferation; negative regulation of neuron differentiation; negative regulation of organ growth; negative regulation of synaptic transmission, dopaminergic; neuron projection; plasma membrane; positive regulation of cell cycle; positive regulation of gene expression; protein homodimerization activity; protein homooligomerization; response to drug; response to estradiol stimulus; response to hypoxia; response to nutrient; response to toxic substance; serotonin uptake; serotonin:sodium symporter activity; social behavior; sperm ejaculation; thalamus development; vasoconstriction" IPR000175; IPR013086; Sodium-dependent serotonin transporter (5HT transporter) (5HTT) (Solute carrier family 6 member 4) Slc6a4 Rattus norvegicus (Rat) TR41837_c1_g1_i7 Q2PG55 S6A13_MACFA 3.00E-09 GO:0005332; GO:0005887; GO:0005328 gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR002981; Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13) SLC6A13 QbsB-10818 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR41837_c1_g1_i8 P31652 SC6A4_RAT 1.00E-08 GO:0051015; GO:0007420; GO:0048854; GO:0071321; GO:0071300; GO:0007623; GO:0019811; GO:0005829; GO:0012505; GO:0010008; GO:0005887; GO:0007626; GO:0045121; GO:0007613; GO:0021941; GO:0045665; GO:0046621; GO:0032227; GO:0043005; GO:0005886; GO:0045787; GO:0010628; GO:0042803; GO:0051260; GO:0042493; GO:0032355; GO:0001666; GO:0007584; GO:0009636; GO:0051610; GO:0005335; GO:0035176; GO:0042713; GO:0021794; GO:0042310 "actin filament binding; brain development; brain morphogenesis; cellular response to cGMP; cellular response to retinoic acid; circadian rhythm; cocaine binding; cytosol; endomembrane system; endosome membrane; integral to plasma membrane; locomotory behavior; membrane raft; memory; negative regulation of cerebellar granule cell precursor proliferation; negative regulation of neuron differentiation; negative regulation of organ growth; negative regulation of synaptic transmission, dopaminergic; neuron projection; plasma membrane; positive regulation of cell cycle; positive regulation of gene expression; protein homodimerization activity; protein homooligomerization; response to drug; response to estradiol stimulus; response to hypoxia; response to nutrient; response to toxic substance; serotonin uptake; serotonin:sodium symporter activity; social behavior; sperm ejaculation; thalamus development; vasoconstriction" IPR000175; IPR013086; Sodium-dependent serotonin transporter (5HT transporter) (5HTT) (Solute carrier family 6 member 4) Slc6a4 Rattus norvegicus (Rat) TR41838_c2_g1_i1 P26009 ITA8_CHICK 3.00E-164 GO:0007155; GO:0030154; GO:0008305; GO:0007229; GO:0046872; GO:0007399 cell adhesion; cell differentiation; integrin complex; integrin-mediated signaling pathway; metal ion binding; nervous system development IPR013517; IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] ITGA8 Gallus gallus (Chicken) TR41838_c2_g1_i2 P26009 ITA8_CHICK 6.00E-165 GO:0007155; GO:0030154; GO:0008305; GO:0007229; GO:0046872; GO:0007399 cell adhesion; cell differentiation; integrin complex; integrin-mediated signaling pathway; metal ion binding; nervous system development IPR013517; IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] ITGA8 Gallus gallus (Chicken) TR41838_c2_g1_i4 Q03600 INA1_CAEEL 2.00E-60 GO:0007413; GO:0010171; GO:0033631; GO:0008305; GO:0007229; GO:0043236; GO:0008078; GO:0002119; GO:0001764; GO:0009887; GO:0045138; GO:0004888 axonal fasciculation; body morphogenesis; cell-cell adhesion mediated by integrin; integrin complex; integrin-mediated signaling pathway; laminin binding; mesodermal cell migration; nematode larval development; neuron migration; organ morphogenesis; tail tip morphogenesis; transmembrane signaling receptor activity IPR013517; IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha ina-1 ina-1 F54G8.3 Caenorhabditis elegans TR41840_c4_g1_i1 Q9NYQ7 CELR3_HUMAN 3.00E-77 GO:0004930; GO:0007413; GO:0005509; GO:0042384; GO:0007156; GO:0016021; GO:0001764; GO:0007218; GO:0005886; GO:0032880 P16333 G-protein coupled receptor activity; axonal fasciculation; calcium ion binding; cilium assembly; homophilic cell adhesion; integral to membrane; neuron migration; neuropeptide signaling pathway; plasma membrane; regulation of protein localization IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR013032; IPR002049; IPR017981; IPR001879; IPR000832; IPR017983; IPR000203; IPR001791; Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) CELSR3 CDHF11 EGFL1 FMI1 KIAA0812 MEGF2 Homo sapiens (Human) TR41840_c4_g1_i4 Q9NYQ7 CELR3_HUMAN 1.00E-78 GO:0004930; GO:0007413; GO:0005509; GO:0042384; GO:0007156; GO:0016021; GO:0001764; GO:0007218; GO:0005886; GO:0032880 P16333 G-protein coupled receptor activity; axonal fasciculation; calcium ion binding; cilium assembly; homophilic cell adhesion; integral to membrane; neuron migration; neuropeptide signaling pathway; plasma membrane; regulation of protein localization IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR013032; IPR002049; IPR017981; IPR001879; IPR000832; IPR017983; IPR000203; IPR001791; Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) CELSR3 CDHF11 EGFL1 FMI1 KIAA0812 MEGF2 Homo sapiens (Human) TR41841_c0_g1_i1 Q9Y6I9 TX264_HUMAN 1.00E-46 GO:0005576 extracellular region IPR010499; IPR011256; Testis-expressed sequence 264 protein (Putative secreted protein Zsig11) TEX264 ZSIG11 UNQ337/PRO536 Homo sapiens (Human) TR41841_c1_g1_i1 Q9Y6F1 PARP3_HUMAN 3.00E-150 GO:0006281; GO:0003950; GO:0003824; GO:0005814; GO:0005634; GO:0006471 DNA repair; NAD+ ADP-ribosyltransferase activity; catalytic activity; centriole; nucleus; protein ADP-ribosylation IPR012317; IPR004102; IPR008893; Poly [ADP-ribose] polymerase 3 (PARP-3) (hPARP-3) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3) PARP3 ADPRT3 ADPRTL3 Homo sapiens (Human) TR41842_c0_g2_i2 Q99K85 SERC_MOUSE 1.00E-174 GO:0006564; GO:0004648; GO:0030170 L-serine biosynthetic process; O-phospho-L-serine:2-oxoglutarate aminotransferase activity; pyridoxal phosphate binding IPR000192; IPR020578; IPR022278; IPR003248; IPR015424; IPR015421; IPR015422; Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5. Phosphoserine aminotransferase (PSAT) (EC 2.6.1.52) (Endometrial progesterone-induced protein) (EPIP) (Phosphohydroxythreonine aminotransferase) Psat1 Psa Psat Mus musculus (Mouse) TR41843_c0_g3_i2 Q6A070 F179B_MOUSE 4.00E-78 IPR011989; IPR016024; Protein FAM179B Fam179b Kiaa0423 Mus musculus (Mouse) TR41843_c0_g3_i3 Q6A070 F179B_MOUSE 4.00E-78 IPR011989; IPR016024; Protein FAM179B Fam179b Kiaa0423 Mus musculus (Mouse) TR41845_c1_g2_i1 A3LRW3 SEC24_PICST 5.00E-153 GO:0030127; GO:0006888; GO:0000139; GO:0005789; GO:0006886; GO:0008270 COPII vesicle coat; ER to Golgi vesicle-mediated transport; Golgi membrane; endoplasmic reticulum membrane; intracellular protein transport; zinc ion binding IPR006900; IPR006896; IPR012990; IPR002035; IPR006895; Protein transport protein SEC24 SEC24 PICST_88354 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis) TR41845_c1_g2_i2 O95487 SC24B_HUMAN 0 GO:0030127; GO:0048208; GO:0012507; GO:0000139; GO:0019886; GO:0002474; GO:0005829; GO:0005789; GO:0006886; GO:0048471; GO:0043687; GO:0018279; GO:0044281; GO:0005215; GO:0008270 COPII vesicle coat; COPII vesicle coating; ER to Golgi transport vesicle membrane; Golgi membrane; antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; cytosol; endoplasmic reticulum membrane; intracellular protein transport; perinuclear region of cytoplasm; post-translational protein modification; protein N-linked glycosylation via asparagine; small molecule metabolic process; transporter activity; zinc ion binding IPR007123; IPR006900; IPR006896; IPR012990; IPR002035; IPR006895; Protein transport protein Sec24B (SEC24-related protein B) SEC24B Homo sapiens (Human) TR41846_c1_g1_i2 O61443 MK14B_DROME 4.00E-166 GO:0005524; GO:0016909; GO:0071243; GO:0071276; GO:0034614; GO:0042742; GO:0050832; GO:0008340; GO:0007476; GO:0006955; GO:0005634; GO:0045793; GO:0040018; GO:0001934; GO:0030510; GO:0048082; GO:0045088; GO:0009408; GO:0042542; GO:0009651; GO:0042594 ATP binding; SAP kinase activity; cellular response to arsenic-containing substance; cellular response to cadmium ion; cellular response to reactive oxygen species; defense response to bacterium; defense response to fungus; determination of adult lifespan; imaginal disc-derived wing morphogenesis; immune response; nucleus; positive regulation of cell size; positive regulation of multicellular organism growth; positive regulation of protein phosphorylation; regulation of BMP signaling pathway; regulation of adult chitin-containing cuticle pigmentation; regulation of innate immune response; response to heat; response to hydrogen peroxide; response to salt stress; response to starvation IPR011009; IPR003527; IPR008352; IPR000719; IPR017441; IPR002290; Mitogen-activated protein kinase 14B (MAP kinase 14B) (MAPK 14B) (EC 2.7.11.24) (MAP kinase p38b) (D-p38b) p38b CG7393 Drosophila melanogaster (Fruit fly) TR41846_c1_g1_i7 P47812 MK14_XENLA 0 GO:0005524; GO:0004707; GO:0038066; GO:0045663; GO:1901741; GO:0010831; GO:0006357; GO:0006351 "ATP binding; MAP kinase activity; p38MAPK cascade; positive regulation of myoblast differentiation; positive regulation of myoblast fusion; positive regulation of myotube differentiation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR011009; IPR003527; IPR008352; IPR000719; IPR017441; IPR002290; Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Mitogen-activated Mitogen-activated protein kinase 2) (MAP kinase 2) (MPK2) mapk14 mpk2 Xenopus laevis (African clawed frog) TR41847_c1_g2_i1 P58854 GCP3_MOUSE 3.00E-139 GO:0005814; GO:0007020; GO:0005827 centriole; microtubule nucleation; polar microtubule IPR015697; IPR007259; Gamma-tubulin complex component 3 (GCP-3) Tubgcp3 Gcp3 Mus musculus (Mouse) TR41849_c0_g2_i2 P22607 FGFR3_HUMAN 2.00E-72 GO:0005524; GO:0038095; GO:0007259; GO:0000165; GO:0061144; GO:0060385; GO:0070977; GO:0022010; GO:0002062; GO:0035988; GO:0090102; GO:0016023; GO:0048546; GO:0003416; GO:0001958; GO:0005783; GO:0007173; GO:0072148; GO:0005576; GO:0017134; GO:1902178; GO:0005007; GO:0045087; GO:0060113; GO:0008286; GO:0005887; GO:0009898; GO:0070307; GO:0002089; GO:0005764; GO:0002009; GO:0043066; GO:0048712; GO:0048640; GO:0050680; GO:0045839; GO:0045879; GO:0000122; GO:0048011; GO:0048471; GO:0048015; GO:0070374; GO:0090080; GO:0043065; GO:0090263; GO:0045597; GO:0008284; GO:0001938; GO:0043552; GO:0010518; GO:0031398; GO:0042511; GO:0042517; GO:0046777; GO:0048678; GO:0035019; GO:0021762 P05230; P08238 ATP binding; Fc-epsilon receptor signaling pathway; JAK-STAT cascade; MAPK cascade; alveolar secondary septum development; axonogenesis involved in innervation; bone maturation; central nervous system myelination; chondrocyte differentiation; chondrocyte proliferation; cochlea development; cytoplasmic membrane-bounded vesicle; digestive tract morphogenesis; endochondral bone growth; endochondral ossification; endoplasmic reticulum; epidermal growth factor receptor signaling pathway; epithelial cell fate commitment; extracellular region; fibroblast growth factor binding; fibroblast growth factor receptor signaling pathway involved in apoptotic process; fibroblast growth factor-activated receptor activity; innate immune response; inner ear receptor cell differentiation; insulin receptor signaling pathway; integral to plasma membrane; internal side of plasma membrane; lens fiber cell development; lens morphogenesis in camera-type eye; lysosome; morphogenesis of an epithelium; negative regulation of apoptotic process; negative regulation of astrocyte differentiation; negative regulation of developmental growth; negative regulation of epithelial cell proliferation; negative regulation of mitosis; negative regulation of smoothened signaling pathway; negative regulation of transcription from RNA polymerase II promoter; neurotrophin TRK receptor signaling pathway; perinuclear region of cytoplasm; phosphatidylinositol-mediated signaling; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway; positive regulation of apoptotic process; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phospholipase activity; positive regulation of protein ubiquitination; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tyrosine phosphorylation of Stat3 protein; protein autophosphorylation; response to axon injury; somatic stem cell maintenance; substantia nigra development IPR028176; IPR016248; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013151; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333) FGFR3 JTK4 Homo sapiens (Human) TR41850_c1_g1_i1 Q5ZL74 VAMP7_CHICK 1.00E-42 GO:0006888; GO:0005794; GO:0043001; GO:0031201; GO:0045177; GO:0017156; GO:0030054; GO:0005789; GO:0008333; GO:0043308; GO:0016021; GO:0031902; GO:0005765; GO:0043005; GO:0043312; GO:0048471; GO:0045335; GO:0030670; GO:0006911; GO:1900483; GO:0045202; GO:0030658; GO:0006906 "ER to Golgi vesicle-mediated transport; Golgi apparatus; Golgi to plasma membrane protein transport; SNARE complex; apical part of cell; calcium ion-dependent exocytosis; cell junction; endoplasmic reticulum membrane; endosome to lysosome transport; eosinophil degranulation; integral to membrane; late endosome membrane; lysosomal membrane; neuron projection; neutrophil degranulation; perinuclear region of cytoplasm; phagocytic vesicle; phagocytic vesicle membrane; phagocytosis, engulfment; regulation of protein targeting to vacuolar membrane; synapse; transport vesicle membrane; vesicle fusion" IPR011012; IPR010908; IPR001388; Vesicle-associated membrane protein 7 (Synaptobrevin-like protein 1) VAMP7 SYBL1 RCJMB04_7f19 Gallus gallus (Chicken) TR41850_c1_g1_i4 Q86AQ7 VAM7B_DICDI 3.00E-31 GO:0005794; GO:0031201; GO:0000331; GO:0005789; GO:0008333; GO:0016021; GO:0031902; GO:0005765; GO:0030670; GO:0015031; GO:0030658; GO:0006906 Golgi apparatus; SNARE complex; contractile vacuole; endoplasmic reticulum membrane; endosome to lysosome transport; integral to membrane; late endosome membrane; lysosomal membrane; phagocytic vesicle membrane; protein transport; transport vesicle membrane; vesicle fusion IPR011012; IPR010908; IPR001388; Vesicle-associated membrane protein 7B vamp7B DDB_G0277173 Dictyostelium discoideum (Slime mold) TR41850_c1_g1_i6 O48850 VA725_ARATH 4.00E-32 GO:0005768; GO:0016021; GO:0005886; GO:0015031; GO:0016192 endosome; integral to membrane; plasma membrane; protein transport; vesicle-mediated transport IPR011012; IPR010908; IPR001388; Vesicle-associated membrane protein 725 (AtVAMP725) VAMP725 At2g32670 F24L7.19 Arabidopsis thaliana (Mouse-ear cress) TR41850_c1_g1_i7 Q5ZL74 VAMP7_CHICK 2.00E-42 GO:0006888; GO:0005794; GO:0043001; GO:0031201; GO:0045177; GO:0017156; GO:0030054; GO:0005789; GO:0008333; GO:0043308; GO:0016021; GO:0031902; GO:0005765; GO:0043005; GO:0043312; GO:0048471; GO:0045335; GO:0030670; GO:0006911; GO:1900483; GO:0045202; GO:0030658; GO:0006906 "ER to Golgi vesicle-mediated transport; Golgi apparatus; Golgi to plasma membrane protein transport; SNARE complex; apical part of cell; calcium ion-dependent exocytosis; cell junction; endoplasmic reticulum membrane; endosome to lysosome transport; eosinophil degranulation; integral to membrane; late endosome membrane; lysosomal membrane; neuron projection; neutrophil degranulation; perinuclear region of cytoplasm; phagocytic vesicle; phagocytic vesicle membrane; phagocytosis, engulfment; regulation of protein targeting to vacuolar membrane; synapse; transport vesicle membrane; vesicle fusion" IPR011012; IPR010908; IPR001388; Vesicle-associated membrane protein 7 (Synaptobrevin-like protein 1) VAMP7 SYBL1 RCJMB04_7f19 Gallus gallus (Chicken) TR41852_c3_g2_i1 A1A4M6 STAR5_BOVIN 7.00E-40 GO:0008289; GO:0006869 lipid binding; lipid transport IPR023393; IPR002913; StAR-related lipid transfer protein 5 (START domain-containing protein 5) (StARD5) STARD5 Bos taurus (Bovine) TR41853_c0_g1_i2 P07686 HEXB_HUMAN 0 GO:0001669; GO:0043615; GO:0004563; GO:0005975; GO:0008219; GO:0006874; GO:0044267; GO:0030207; GO:0006689; GO:0006687; GO:0030214; GO:0042340; GO:0019915; GO:0007626; GO:0043202; GO:0007040; GO:0008049; GO:0016020; GO:0042552; GO:0050885; GO:0009313; GO:0048477; GO:0007341; GO:0008654; GO:0045944; GO:0046982; GO:0042803; GO:0008360; GO:0007605; GO:0001501 acrosomal vesicle; astrocyte cell migration; beta-N-acetylhexosaminidase activity; carbohydrate metabolic process; cell death; cellular calcium ion homeostasis; cellular protein metabolic process; chondroitin sulfate catabolic process; ganglioside catabolic process; glycosphingolipid metabolic process; hyaluronan catabolic process; keratan sulfate catabolic process; lipid storage; locomotory behavior; lysosomal lumen; lysosome organization; male courtship behavior; membrane; myelination; neuromuscular process controlling balance; oligosaccharide catabolic process; oogenesis; penetration of zona pellucida; phospholipid biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; protein homodimerization activity; regulation of cell shape; sensory perception of sound; skeletal system development IPR025705; IPR015883; IPR013781; IPR017853; Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] HEXB HCC7 Homo sapiens (Human) TR41857_c0_g1_i2 P27512 TNR5_MOUSE 1.00E-07 GO:0042113; GO:0035631; GO:0006874; GO:0071260; GO:0051607; GO:0009897; GO:0005576; GO:0002768; GO:0043231; GO:0030890; GO:0043089; GO:0043123; GO:0043406; GO:0051092; GO:0032855; GO:2000353; GO:0032735; GO:0048304; GO:0090037; GO:0045944; GO:0042511; GO:0051023 P35991; P70196 B cell activation; CD40 receptor complex; cellular calcium ion homeostasis; cellular response to mechanical stimulus; defense response to virus; external side of plasma membrane; extracellular region; immune response-regulating cell surface receptor signaling pathway; intracellular membrane-bounded organelle; positive regulation of B cell proliferation; positive regulation of Cdc42 GTPase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAP kinase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of Rac GTPase activity; positive regulation of endothelial cell apoptotic process; positive regulation of interleukin-12 production; positive regulation of isotype switching to IgG isotypes; positive regulation of protein kinase C signaling cascade; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of immunoglobulin secretion IPR001368; IPR020435; Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CD antigen CD40) Cd40 Tnfrsf5 Mus musculus (Mouse) TR41857_c0_g1_i3 P27512 TNR5_MOUSE 4.00E-08 GO:0042113; GO:0035631; GO:0006874; GO:0071260; GO:0051607; GO:0009897; GO:0005576; GO:0002768; GO:0043231; GO:0030890; GO:0043089; GO:0043123; GO:0043406; GO:0051092; GO:0032855; GO:2000353; GO:0032735; GO:0048304; GO:0090037; GO:0045944; GO:0042511; GO:0051023 P35991; P70196 B cell activation; CD40 receptor complex; cellular calcium ion homeostasis; cellular response to mechanical stimulus; defense response to virus; external side of plasma membrane; extracellular region; immune response-regulating cell surface receptor signaling pathway; intracellular membrane-bounded organelle; positive regulation of B cell proliferation; positive regulation of Cdc42 GTPase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAP kinase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of Rac GTPase activity; positive regulation of endothelial cell apoptotic process; positive regulation of interleukin-12 production; positive regulation of isotype switching to IgG isotypes; positive regulation of protein kinase C signaling cascade; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of immunoglobulin secretion IPR001368; IPR020435; Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CD antigen CD40) Cd40 Tnfrsf5 Mus musculus (Mouse) TR41858_c0_g1_i1 Q3TSG4 ALKB5_MOUSE 5.00E-111 GO:0030154; GO:0006406; GO:0006397; GO:0046872; GO:0016607; GO:0035515; GO:0035553; GO:0016706; GO:0001666; GO:0007283 "cell differentiation; mRNA export from nucleus; mRNA processing; metal ion binding; nuclear speck; oxidative RNA demethylase activity; oxidative single-stranded RNA demethylation; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; response to hypoxia; spermatogenesis" IPR027450; RNA demethylase ALKBH5 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) Alkbh5 Abh5 Ofoxd Mus musculus (Mouse) TR41859_c3_g1_i1 Q92581 SL9A6_HUMAN 9.00E-179 GO:0031901; GO:0005789; GO:0016021; GO:0005886; GO:0055038; GO:0006885; GO:0015385 early endosome membrane; endoplasmic reticulum membrane; integral to membrane; plasma membrane; recycling endosome membrane; regulation of pH; sodium:hydrogen antiporter activity IPR006153; IPR018422; IPR002090; IPR004709; Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) (Solute carrier family 9 member 6) SLC9A6 KIAA0267 NHE6 Homo sapiens (Human) TR41859_c3_g1_i3 Q8BLV3 SL9A7_MOUSE 5.00E-169 GO:0005794; GO:0016021; GO:0015386; GO:0055038; GO:0006885; GO:0015385; GO:0005802 Golgi apparatus; integral to membrane; potassium:hydrogen antiporter activity; recycling endosome membrane; regulation of pH; sodium:hydrogen antiporter activity; trans-Golgi network IPR006153; IPR018422; IPR002090; IPR004709; Sodium/hydrogen exchanger 7 (Na(+)/H(+) exchanger 7) (NHE-7) (Solute carrier family 9 member 7) Slc9a7 Nhe7 Mus musculus (Mouse) TR41859_c3_g1_i5 Q96T83 SL9A7_HUMAN 1.00E-51 GO:0000139; GO:0016021; GO:0015386; GO:0042803; GO:0055038; GO:0006885; GO:0015385; GO:0005802 Golgi membrane; integral to membrane; potassium:hydrogen antiporter activity; protein homodimerization activity; recycling endosome membrane; regulation of pH; sodium:hydrogen antiporter activity; trans-Golgi network IPR006153; IPR018422; IPR002090; IPR004709; Sodium/hydrogen exchanger 7 (Na(+)/H(+) exchanger 7) (NHE-7) (Solute carrier family 9 member 7) SLC9A7 NHE7 Homo sapiens (Human) TR41859_c3_g1_i7 Q92581 SL9A6_HUMAN 3.00E-60 GO:0031901; GO:0005789; GO:0016021; GO:0005886; GO:0055038; GO:0006885; GO:0015385 early endosome membrane; endoplasmic reticulum membrane; integral to membrane; plasma membrane; recycling endosome membrane; regulation of pH; sodium:hydrogen antiporter activity IPR006153; IPR018422; IPR002090; IPR004709; Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) (Solute carrier family 9 member 6) SLC9A6 KIAA0267 NHE6 Homo sapiens (Human) TR41860_c1_g3_i2 B4LQ44 QVR_DROVI 4.00E-13 GO:0034235; GO:0031225; GO:0005886; GO:0045187 "GPI anchor binding; anchored to membrane; plasma membrane; regulation of circadian sleep/wake cycle, sleep" Protein quiver (Protein sleepless) qvr sss GJ20359 Drosophila virilis (Fruit fly) TR41860_c1_g3_i4 B5E022 QVR_DROPS 2.00E-11 GO:0034235; GO:0031225; GO:0005886; GO:0045187 "GPI anchor binding; anchored to membrane; plasma membrane; regulation of circadian sleep/wake cycle, sleep" Protein quiver (Protein sleepless) qvr sss GA24714 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR41860_c1_g3_i6 B5E022 QVR_DROPS 1.00E-11 GO:0034235; GO:0031225; GO:0005886; GO:0045187 "GPI anchor binding; anchored to membrane; plasma membrane; regulation of circadian sleep/wake cycle, sleep" Protein quiver (Protein sleepless) qvr sss GA24714 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR41861_c4_g1_i1 Q95114 MFGM_BOVIN 2.00E-07 GO:0001525; GO:0007155; GO:0005576; GO:0016020; GO:0007338 angiogenesis; cell adhesion; extracellular region; membrane; single fertilization IPR000421; IPR000742; IPR013032; IPR008979; IPR027060; Lactadherin (BP47) (Components 15/16) (MFGM) (MGP57/53) (Milk fat globule-EGF factor 8) (MFG-E8) (PAS-6/PAS-7 glycoprotein) (SED1) (Sperm surface protein SP47) MFGE8 Bos taurus (Bovine) TR41861_c4_g1_i3 Q9R098 HGFA_MOUSE 2.00E-09 GO:0005615; GO:0006508; GO:0005791; GO:0004252 extracellular space; proteolysis; rough endoplasmic reticulum; serine-type endopeptidase activity IPR014394; IPR000742; IPR013032; IPR000083; IPR000562; IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR009003; Hepatocyte growth factor activator (HGF activator) (HGFA) (EC 3.4.21.-) [Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain] Hgfac Mus musculus (Mouse) TR41861_c4_g1_i4 B4LCX4 CUE_DROVI 4.00E-08 GO:0030154; GO:0016021; GO:0048477; GO:0005886; GO:0007283 cell differentiation; integral to membrane; oogenesis; plasma membrane; spermatogenesis IPR011042; IPR000742; IPR013032; IPR000033; Protein cueball cue GJ12465 Drosophila virilis (Fruit fly) TR41861_c5_g1_i1 Q9VW71 FAT2_DROME 2.00E-25 GO:0009925; GO:0005509; GO:0016339; GO:0050839; GO:0050829; GO:0042247; GO:0030950; GO:0005925; GO:0007440; GO:0007295; GO:0007442; GO:0007156; GO:0005887; GO:0045571; GO:0007424; GO:0045089; GO:0004872; GO:0007431 basal plasma membrane; calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; defense response to Gram-negative bacterium; establishment of planar polarity of follicular epithelium; establishment or maintenance of actin cytoskeleton polarity; focal adhesion; foregut morphogenesis; growth of a germarium-derived egg chamber; hindgut morphogenesis; homophilic cell adhesion; integral to plasma membrane; negative regulation of imaginal disc growth; open tracheal system development; positive regulation of innate immune response; receptor activity; salivary gland development IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Fat-like cadherin-related tumor suppressor homolog (Protein kugelei) kug fat2 CG7749 Drosophila melanogaster (Fruit fly) TR41861_c5_g1_i2 P10079 FBP1_STRPU 5.00E-55 GO:0032579; GO:0005509; GO:0016023; GO:0005615 apical lamina of hyaline layer; calcium ion binding; cytoplasmic membrane-bounded vesicle; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) TR41861_c5_g1_i3 Q9NYJ7 DLL3_HUMAN 2.00E-25 GO:0005112; GO:0007219; GO:0007386; GO:0016021; GO:0050768; GO:0048339; GO:0001501; GO:0001756 Notch binding; Notch signaling pathway; compartment pattern specification; integral to membrane; negative regulation of neurogenesis; paraxial mesoderm development; skeletal system development; somitogenesis IPR000742; IPR013032; IPR009030; IPR011651; Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3) DLL3 Homo sapiens (Human) TR41861_c6_g1_i1 Q14517 FAT1_HUMAN 3.00E-30 GO:0007015; GO:0009653; GO:0005509; GO:0016477; GO:0016337; GO:0005911; GO:0007267; GO:0007163; GO:0030175; GO:0007156; GO:0005887; GO:0030027; GO:0005634; GO:0048471 Q8N8S7; Q9NSC5; Q99JP6 actin filament organization; anatomical structure morphogenesis; calcium ion binding; cell migration; cell-cell adhesion; cell-cell junction; cell-cell signaling; establishment or maintenance of cell polarity; filopodium; homophilic cell adhesion; integral to plasma membrane; lamellipodium; nucleus; perinuclear region of cytoplasm IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) TR41861_c6_g1_i2 O00548 DLL1_HUMAN 3.00E-31 GO:0007220; GO:0007219; GO:0005509; GO:0001709; GO:0007267; GO:0007386; GO:0031410; GO:0005576; GO:0001947; GO:0030097; GO:0048839; GO:0005887; GO:0070986; GO:0072070; GO:0045608; GO:0045638; GO:0097150; GO:0045747; GO:0045944; GO:0072014; GO:0030155; GO:0001757 Notch receptor processing; Notch signaling pathway; calcium ion binding; cell fate determination; cell-cell signaling; compartment pattern specification; cytoplasmic vesicle; extracellular region; heart looping; hemopoiesis; inner ear development; integral to plasma membrane; left/right axis specification; loop of Henle development; negative regulation of auditory receptor cell differentiation; negative regulation of myeloid cell differentiation; neuronal stem cell maintenance; positive regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; proximal tubule development; regulation of cell adhesion; somite specification IPR001774; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR011651; Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1) (H-Delta-1) DLL1 UNQ146/PRO172 Homo sapiens (Human) TR41861_c7_g1_i1 Q5RDI1 PAMR1_PONAB 2.00E-06 GO:0003824; GO:0005576; GO:0008152 catalytic activity; extracellular region; metabolic process IPR000859; IPR000742; IPR013032; IPR001254; IPR001314; IPR000436; IPR009003; Inactive serine protease PAMR1 (Peptidase domain-containing protein associated with muscle regeneration 1) (Regeneration-associated muscle protease homolog) PAMR1 RAMP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41862_c1_g2_i6 Q9ESE2 TNF11_RAT 8.00E-07 GO:0030154; GO:0005615; GO:0006955; GO:0016021; GO:0007275; GO:0005886; GO:0045780; GO:0045672; GO:0009314 cell differentiation; extracellular space; immune response; integral to membrane; multicellular organismal development; plasma membrane; positive regulation of bone resorption; positive regulation of osteoclast differentiation; response to radiation IPR006052; IPR017355; IPR008983; "Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]" Tnfsf11 Opgl Rankl Trance Rattus norvegicus (Rat) TR41863_c1_g1_i1 Q9I929 FUCL3_ANGJA 7.00E-09 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-3 Anguilla japonica (Japanese eel) TR41863_c1_g1_i2 Q9I929 FUCL3_ANGJA 1.00E-09 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-3 Anguilla japonica (Japanese eel) TR41863_c1_g1_i7 Q9I925 FUCL7_ANGJA 1.00E-07 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-7 Anguilla japonica (Japanese eel) TR41865_c0_g1_i1 O88450 DEAF1_RAT 1.00E-60 GO:0003677; GO:0048706; GO:0005576; GO:0046872; GO:0001843; GO:0005634; GO:0045944; GO:0033599; GO:0006351 "DNA binding; embryonic skeletal system development; extracellular region; metal ion binding; neural tube closure; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of mammary gland epithelial cell proliferation; transcription, DNA-dependent" IPR000770; IPR010919; IPR024119; IPR002893; Deformed epidermal autoregulatory factor 1 homolog (Nuclear DEAF-1-related transcriptional regulator) (NUDR) (Suppressin) Deaf1 Spn Rattus norvegicus (Rat) TR41865_c0_g1_i6 O88450 DEAF1_RAT 1.00E-60 GO:0003677; GO:0048706; GO:0005576; GO:0046872; GO:0001843; GO:0005634; GO:0045944; GO:0033599; GO:0006351 "DNA binding; embryonic skeletal system development; extracellular region; metal ion binding; neural tube closure; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of mammary gland epithelial cell proliferation; transcription, DNA-dependent" IPR000770; IPR010919; IPR024119; IPR002893; Deformed epidermal autoregulatory factor 1 homolog (Nuclear DEAF-1-related transcriptional regulator) (NUDR) (Suppressin) Deaf1 Spn Rattus norvegicus (Rat) TR41868_c3_g1_i1 Q8IVL6 P3H3_HUMAN 2.00E-62 GO:0031418; GO:0005788; GO:0030198; GO:0005506; GO:0008285; GO:0019797 L-ascorbic acid binding; endoplasmic reticulum lumen; extracellular matrix organization; iron ion binding; negative regulation of cell proliferation; procollagen-proline 3-dioxygenase activity IPR005123; IPR006620; IPR011990; Prolyl 3-hydroxylase 3 (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B) LEPREL2 P3H3 Homo sapiens (Human) TR41868_c3_g1_i2 Q6JHU7 P3H2_CHICK 5.00E-64 GO:0005794; GO:0031418; GO:0005604; GO:0032963; GO:0005783; GO:0005506; GO:0008285; GO:0019511; GO:0019797 Golgi apparatus; L-ascorbic acid binding; basement membrane; collagen metabolic process; endoplasmic reticulum; iron ion binding; negative regulation of cell proliferation; peptidyl-proline hydroxylation; procollagen-proline 3-dioxygenase activity IPR005123; IPR006620; IPR011990; Prolyl 3-hydroxylase 2 (EC 1.14.11.7) (Leprecan-like protein 1) LEPREL1 P3H2 Gallus gallus (Chicken) TR41868_c3_g1_i4 Q6JHU7 P3H2_CHICK 5.00E-64 GO:0005794; GO:0031418; GO:0005604; GO:0032963; GO:0005783; GO:0005506; GO:0008285; GO:0019511; GO:0019797 Golgi apparatus; L-ascorbic acid binding; basement membrane; collagen metabolic process; endoplasmic reticulum; iron ion binding; negative regulation of cell proliferation; peptidyl-proline hydroxylation; procollagen-proline 3-dioxygenase activity IPR005123; IPR006620; IPR011990; Prolyl 3-hydroxylase 2 (EC 1.14.11.7) (Leprecan-like protein 1) LEPREL1 P3H2 Gallus gallus (Chicken) TR41868_c3_g1_i5 Q90830 CRTAP_CHICK 6.00E-13 GO:0005578 Q6JHU8 proteinaceous extracellular matrix IPR011990 Cartilage-associated protein (Dualin) CRTAP CASP Gallus gallus (Chicken) TR41869_c0_g1_i2 Q05209 PTN12_HUMAN 1.00E-75 GO:0030054; GO:0042995; GO:0005737; GO:0005829; GO:0004726; GO:0005886; GO:0002102 P56945; P04626; P09619; Q02763 cell junction; cell projection; cytoplasm; cytosol; non-membrane spanning protein tyrosine phosphatase activity; plasma membrane; podosome IPR012266; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) PTPN12 Homo sapiens (Human) TR41869_c0_g1_i5 P28198 PTP6_STYPL 1.00E-18 GO:0035335; GO:0004725 peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR000242; Tyrosine-protein phosphatase 6 (EC 3.1.3.48) (Fragment) STY-6 Styela plicata (Sea squirt) (Ascidia plicata) TR41870_c0_g2_i1 Q9VN14 CONT_DROME 8.00E-80 GO:0031225; GO:0008366; GO:0030246; GO:0061343; GO:0060857; GO:0045197; GO:0021682; GO:0005886; GO:0005918; GO:0019991 anchored to membrane; axon ensheathment; carbohydrate binding; cell adhesion involved in heart morphogenesis; establishment of glial blood-brain barrier; establishment or maintenance of epithelial cell apical/basal polarity; nerve maturation; plasma membrane; septate junction; septate junction assembly IPR001304; IPR016186; IPR016187; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Contactin Cont CG1084 Drosophila melanogaster (Fruit fly) TR41870_c0_g2_i3 Q60ZN5 SDK_CAEBR 4.00E-14 GO:0007155; GO:0016021 cell adhesion; integral to membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Protein sidekick homolog (Neuronal IgCAM protein 4) rig-4 CBG17724 Caenorhabditis briggsae TR41871_c0_g1_i1 Q9NYH9 UTP6_HUMAN 7.00E-71 GO:0005730; GO:0006364 nucleolus; rRNA processing IPR003107; IPR011990; IPR013949; U3 small nucleolar RNA-associated protein 6 homolog (Hepatocellular carcinoma-associated antigen 66) (Multiple hat domains protein) UTP6 C17orf40 HCA66 MHAT Homo sapiens (Human) TR41871_c0_g1_i6 Q9NYH9 UTP6_HUMAN 6.00E-70 GO:0005730; GO:0006364 nucleolus; rRNA processing IPR003107; IPR011990; IPR013949; U3 small nucleolar RNA-associated protein 6 homolog (Hepatocellular carcinoma-associated antigen 66) (Multiple hat domains protein) UTP6 C17orf40 HCA66 MHAT Homo sapiens (Human) TR41872_c0_g2_i1 P28288 ABCD3_HUMAN 0 GO:0005524; GO:0016887; GO:0042626; GO:0005829; GO:0006635; GO:0016021; GO:0005743; GO:0005782; GO:0005778; GO:0007031; GO:0042803; GO:0055085; GO:0042760 P33897; P40855 "ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; cytosol; fatty acid beta-oxidation; integral to membrane; mitochondrial inner membrane; peroxisomal matrix; peroxisomal membrane; peroxisome organization; protein homodimerization activity; transmembrane transport; very long-chain fatty acid catabolic process" IPR003593; IPR011527; IPR010509; IPR003439; IPR017871; IPR005283; IPR027417; ATP-binding cassette sub-family D member 3 (70 kDa peroxisomal membrane protein) (PMP70) ABCD3 PMP70 PXMP1 Homo sapiens (Human) TR41876_c3_g2_i1 Q9YGC1 BLNK_CHICK 1.00E-13 GO:0042113; GO:0005829; GO:0005886 B cell activation; cytosol; plasma membrane IPR000980; B-cell linker protein (B-cell adapter SH2 domain-containing protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) BLNK BASH Gallus gallus (Chicken) TR41876_c3_g2_i4 Q9YGC1 BLNK_CHICK 6.00E-14 GO:0042113; GO:0005829; GO:0005886 B cell activation; cytosol; plasma membrane IPR000980; B-cell linker protein (B-cell adapter SH2 domain-containing protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) BLNK BASH Gallus gallus (Chicken) TR41876_c3_g2_i6 Q9D413 SH2D6_MOUSE 3.00E-11 IPR000980; SH2 domain-containing protein 6 Sh2d6 Mus musculus (Mouse) TR41879_c4_g1_i1 Q92035 ACES_BUNFA 1.00E-62 GO:0001507; GO:0003990; GO:0004091; GO:0030054; GO:0005576; GO:0005886; GO:0045202 acetylcholine catabolic process in synaptic cleft; acetylcholinesterase activity; carboxylesterase activity; cell junction; extracellular region; plasma membrane; synapse IPR014788; IPR000908; IPR002018; IPR019826; IPR019819; IPR000997; Acetylcholinesterase (AChE) (EC 3.1.1.7) ACHE Bungarus fasciatus (Banded krait) TR41880_c0_g1_i1 Q18674 RRP1_CAEEL 1.00E-26 GO:0005634; GO:0030688; GO:0006364 "nucleus; preribosome, small subunit precursor; rRNA processing" IPR010301; Ribosomal RNA processing protein 1 homolog (RRP1-like protein) C47E12.7 Caenorhabditis elegans TR41880_c0_g1_i3 P56182 RRP1_HUMAN 2.00E-45 GO:0005730; GO:0030688; GO:0006364 "nucleolus; preribosome, small subunit precursor; rRNA processing" IPR010301; Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein) RRP1 D21S2056E NNP1 NOP52 RRP1A Homo sapiens (Human) TR41882_c1_g3_i1 Q0EEE2 PTHD3_MOUSE 5.00E-85 GO:0008158; GO:0016021 hedgehog receptor activity; integral to membrane IPR003392; IPR000731; Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) TR41882_c1_g3_i2 Q03602 PTR9_CAEEL 1.00E-40 GO:0016021; GO:0018996 "integral to membrane; molting cycle, collagen and cuticulin-based cuticle" IPR000731; Patched-related protein 9 ptr-9 F54G8.5 Caenorhabditis elegans TR41882_c1_g3_i3 Q0EEE2 PTHD3_MOUSE 9.00E-86 GO:0008158; GO:0016021 hedgehog receptor activity; integral to membrane IPR003392; IPR000731; Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) TR41882_c1_g3_i4 Q09614 PTC1_CAEEL 1.00E-15 GO:0051301; GO:0008158; GO:0005887; GO:0007067; GO:0018996 "cell division; hedgehog receptor activity; integral to plasma membrane; mitosis; molting cycle, collagen and cuticulin-based cuticle" IPR003392; IPR000731; Protein patched homolog 1 ptc-1 ZK675.1 Caenorhabditis elegans TR41883_c0_g1_i2 Q6NVC5 MIRO1_DANRE 3.00E-136 GO:0005525; GO:0006184; GO:0003924; GO:0005509; GO:0019725; GO:0031307; GO:0097345; GO:0047497; GO:0007264 GTP binding; GTP catabolic process; GTPase activity; calcium ion binding; cellular homeostasis; integral to mitochondrial outer membrane; mitochondrial outer membrane permeabilization; mitochondrion transport along microtubule; small GTPase mediated signal transduction IPR011992; IPR018247; IPR013566; IPR013567; IPR002048; IPR020860; IPR013684; IPR027417; IPR021181; IPR005225; IPR001806; Mitochondrial Rho GTPase 1-A (MIRO-1-A) (EC 3.6.5.-) (Ras homolog gene family member T1-A) rhot1a zgc:55581 Danio rerio (Zebrafish) (Brachydanio rerio) TR41883_c0_g1_i3 Q38912 RAC3_ARATH 6.00E-13 GO:0005525; GO:0003924; GO:0005737; GO:0005730; GO:0005886; GO:0030427; GO:0007264; GO:0005819 GTP binding; GTPase activity; cytoplasm; nucleolus; plasma membrane; site of polarized growth; small GTPase mediated signal transduction; spindle IPR027417; IPR005225; IPR001806; IPR003578; Rac-like GTP-binding protein ARAC3 (GTPase protein ROP6) ARAC3 RAC1 ROP6 At4g35020 M4E13.80 Arabidopsis thaliana (Mouse-ear cress) TR41883_c0_g2_i1 Q5ABR2 GEM1_CANAL 1.00E-33 GO:0005525; GO:0006184; GO:0003924; GO:0005509; GO:0019725; GO:0016021; GO:0005741; GO:0007264 GTP binding; GTP catabolic process; GTPase activity; calcium ion binding; cellular homeostasis; integral to membrane; mitochondrial outer membrane; small GTPase mediated signal transduction IPR011992; IPR018247; IPR013566; IPR013567; IPR002048; IPR020860; IPR013684; IPR027417; IPR021181; IPR001806; Mitochondrial Rho GTPase 1 (EC 3.6.5.-) (GTPase EF-hand protein of mitochondria 1) GEM1 CaO19.13437 CaO19.6016 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) TR41885_c0_g1_i1 Q5EA50 RABEK_BOVIN 6.00E-90 GO:0010008; GO:0005886 endosome membrane; plasma membrane IPR015915; IPR011498; Rab9 effector protein with kelch motifs RABEPK Bos taurus (Bovine) TR41886_c3_g2_i1 Q8K1Q0 NMT1_RAT 0 GO:0006499; GO:0015629; GO:0030054; GO:0005737; GO:0004379; GO:0001701; GO:0019107; GO:0005886 N-terminal protein myristoylation; actin cytoskeleton; cell junction; cytoplasm; glycylpeptide N-tetradecanoyltransferase activity; in utero embryonic development; myristoyltransferase activity; plasma membrane IPR016181; IPR000903; IPR022677; IPR022678; IPR022676; Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1) Nmt1 Rattus norvegicus (Rat) TR41886_c3_g2_i3 P34809 NMT_CRYNV 1.00E-120 GO:0006499; GO:0005737; GO:0004379 N-terminal protein myristoylation; cytoplasm; glycylpeptide N-tetradecanoyltransferase activity IPR016181; IPR000903; IPR022677; IPR022678; IPR022676; Glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase) (NMT) (Peptide N-myristoyltransferase) Cryptococcus neoformans (Filobasidiella neoformans) TR41886_c3_g2_i4 Q8K1Q0 NMT1_RAT 0 GO:0006499; GO:0015629; GO:0030054; GO:0005737; GO:0004379; GO:0001701; GO:0019107; GO:0005886 N-terminal protein myristoylation; actin cytoskeleton; cell junction; cytoplasm; glycylpeptide N-tetradecanoyltransferase activity; in utero embryonic development; myristoyltransferase activity; plasma membrane IPR016181; IPR000903; IPR022677; IPR022678; IPR022676; Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1) Nmt1 Rattus norvegicus (Rat) TR41889_c0_g1_i1 P53879 RHO5_YEAST 3.00E-09 GO:0005525; GO:0003924; GO:0007266; GO:0012505; GO:0000329; GO:0005886 GTP binding; GTPase activity; Rho protein signal transduction; endomembrane system; fungal-type vacuole membrane; plasma membrane IPR027417; IPR005225; IPR001806; IPR003578; GTP-binding protein RHO5 RHO5 YNL180C N1644 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41889_c0_g1_i2 Q05975 RAB2_LYMST 1.00E-133 GO:0005525; GO:0000139; GO:0005789; GO:0033116; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi membrane; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-2 RAB2 Lymnaea stagnalis (Great pond snail) TR41890_c3_g2_i1 Q99698 LYST_HUMAN 0 GO:0002456; GO:0007596; GO:0005829; GO:0042742; GO:0042832; GO:0051607; GO:0032510; GO:0030595; GO:0007040; GO:0033364; GO:0032438; GO:0015630; GO:0007017; GO:0042267; GO:0002446; GO:0055091; GO:0006644; GO:0032816; GO:0042493; GO:0033299 T cell mediated immunity; blood coagulation; cytosol; defense response to bacterium; defense response to protozoan; defense response to virus; endosome to lysosome transport via multivesicular body sorting pathway; leukocyte chemotaxis; lysosome organization; mast cell secretory granule organization; melanosome organization; microtubule cytoskeleton; microtubule-based process; natural killer cell mediated cytotoxicity; neutrophil mediated immunity; phospholipid homeostasis; phospholipid metabolic process; positive regulation of natural killer cell activation; response to drug; secretion of lysosomal enzymes IPR016024; IPR000409; IPR023362; IPR015943; IPR001680; IPR019775; IPR017986; Lysosomal-trafficking regulator (Beige homolog) LYST CHS CHS1 Homo sapiens (Human) TR41890_c3_g2_i2 Q9TTK4 LYST_BOVIN 9.00E-125 GO:0005737; GO:0032510; GO:0015630; GO:0042267; GO:0043473; GO:0015031 cytoplasm; endosome to lysosome transport via multivesicular body sorting pathway; microtubule cytoskeleton; natural killer cell mediated cytotoxicity; pigmentation; protein transport IPR000409; IPR023362; IPR015943; IPR001680; IPR019775; IPR017986; Lysosomal-trafficking regulator LYST Bos taurus (Bovine) TR41892_c2_g1_i1 E1BNG3 ASCC3_BOVIN 0 GO:0005524; GO:0043140; GO:0006307; GO:0008283; GO:0005737; GO:0003676; GO:0005634; GO:0006355; GO:0006351 "ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA dealkylation involved in DNA repair; cell proliferation; cytoplasm; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003593; IPR011545; IPR014001; IPR001650; IPR014756; IPR027417; IPR004179; Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) ascc3 Bos taurus (Bovine) TR41892_c2_g1_i2 Q9CZU3 SK2L2_MOUSE 9.00E-17 GO:0005524; GO:0008026; GO:0008380; GO:0071013; GO:0000178; GO:0006397; GO:0000460; GO:0003676; GO:0005730 ATP binding; ATP-dependent helicase activity; RNA splicing; catalytic step 2 spliceosome; exosome (RNase complex); mRNA processing; maturation of 5.8S rRNA; nucleic acid binding; nucleolus IPR011545; IPR012961; IPR014001; IPR001650; IPR027417; IPR016438; IPR025696; Superkiller viralicidic activity 2-like 2 (EC 3.6.4.13) (ATP-dependent helicase SKIV2L2) Skiv2l2 Mus musculus (Mouse) TR41892_c2_g3_i4 F1NTD6 ASCC3_CHICK 0 GO:0005524; GO:0043140; GO:0006307; GO:0008283; GO:0005737; GO:0003676; GO:0005634; GO:0006355; GO:0006351 "ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA dealkylation involved in DNA repair; cell proliferation; cytoplasm; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003593; IPR011545; IPR014001; IPR001650; IPR014756; IPR027417; IPR004179; Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) ascc3 Gallus gallus (Chicken) TR41892_c2_g3_i6 E7F8F4 ASCC3_DANRE 1.00E-106 GO:0005524; GO:0043140; GO:0006307; GO:0008283; GO:0005737; GO:0003676; GO:0005634; GO:0006355; GO:0006351 "ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA dealkylation involved in DNA repair; cell proliferation; cytoplasm; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003593; IPR011545; IPR014001; IPR001650; IPR027417; IPR004179; Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) ascc3 Danio rerio (Zebrafish) (Brachydanio rerio) TR41892_c2_g3_i8 E1BNG3 ASCC3_BOVIN 4.00E-25 GO:0005524; GO:0043140; GO:0006307; GO:0008283; GO:0005737; GO:0003676; GO:0005634; GO:0006355; GO:0006351 "ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA dealkylation involved in DNA repair; cell proliferation; cytoplasm; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003593; IPR011545; IPR014001; IPR001650; IPR014756; IPR027417; IPR004179; Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) ascc3 Bos taurus (Bovine) TR41893_c0_g1_i3 Q5RDP4 SYLM_PONAB 0 GO:0005524; GO:0002161; GO:0004823; GO:0006429; GO:0005759; GO:0006450 ATP binding; aminoacyl-tRNA editing activity; leucine-tRNA ligase activity; leucyl-tRNA aminoacylation; mitochondrial matrix; regulation of translational fidelity IPR001412; IPR002300; IPR002302; IPR014729; IPR009080; IPR013155; IPR009008; "Probable leucine--tRNA ligase, mitochondrial (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)" LARS2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41893_c0_g1_i7 B7JYA9 SYL_CYAP8 2.00E-14 GO:0005524; GO:0002161; GO:0005737; GO:0004823; GO:0006429; GO:0006450 ATP binding; aminoacyl-tRNA editing activity; cytoplasm; leucine-tRNA ligase activity; leucyl-tRNA aminoacylation; regulation of translational fidelity IPR001412; IPR002300; IPR002302; IPR025709; IPR014729; IPR009080; IPR013155; IPR009008; Leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) leuS PCC8801_3236 Cyanothece sp. (strain PCC 8801) (Synechococcus sp. (strain PCC 8801 / RF-1)) TR41894_c0_g1_i5 Q3UCV8 F105B_MOUSE 7.00E-43 GO:0060070; GO:0005737; GO:0045087; GO:0032088; GO:0050728; GO:0070431; GO:1990108; GO:0006508; GO:0002040; GO:0004843 canonical Wnt receptor signaling pathway; cytoplasm; innate immune response; negative regulation of NF-kappaB transcription factor activity; negative regulation of inflammatory response; nucleotide-binding oligomerization domain containing 2 signaling pathway; protein linear deubiquitination; proteolysis; sprouting angiogenesis; ubiquitin-specific protease activity IPR023235; IPR023237; IPR019400; Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby) Fam105b Gum Mus musculus (Mouse) TR41894_c0_g1_i6 Q9NUU6 F105A_HUMAN 2.00E-25 IPR023235; IPR023236; Inactive ubiquitin thioesterase FAM105A FAM105A Homo sapiens (Human) TR41894_c0_g1_i7 Q3UCV8 F105B_MOUSE 3.00E-43 GO:0060070; GO:0005737; GO:0045087; GO:0032088; GO:0050728; GO:0070431; GO:1990108; GO:0006508; GO:0002040; GO:0004843 canonical Wnt receptor signaling pathway; cytoplasm; innate immune response; negative regulation of NF-kappaB transcription factor activity; negative regulation of inflammatory response; nucleotide-binding oligomerization domain containing 2 signaling pathway; protein linear deubiquitination; proteolysis; sprouting angiogenesis; ubiquitin-specific protease activity IPR023235; IPR023237; IPR019400; Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby) Fam105b Gum Mus musculus (Mouse) TR41894_c0_g1_i8 Q96BN8 F105B_HUMAN 5.00E-42 GO:0060070; GO:0005737; GO:0045087; GO:0032088; GO:0050728; GO:0070431; GO:1990108; GO:0006508; GO:0002040; GO:0004843 canonical Wnt receptor signaling pathway; cytoplasm; innate immune response; negative regulation of NF-kappaB transcription factor activity; negative regulation of inflammatory response; nucleotide-binding oligomerization domain containing 2 signaling pathway; protein linear deubiquitination; proteolysis; sprouting angiogenesis; ubiquitin-specific protease activity IPR023235; IPR023237; Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby) FAM105B Homo sapiens (Human) TR41895_c0_g1_i1 Q5ZLD7 VPS53_CHICK 0 GO:0005794; GO:0010008; GO:0015031 Golgi apparatus; endosome membrane; protein transport IPR007234; Vacuolar protein sorting-associated protein 53 homolog VPS53 RCJMB04_6k3 Gallus gallus (Chicken) TR41896_c1_g1_i1 Q6ZUJ8 BCAP_HUMAN 5.00E-15 GO:0005829; GO:0034122; GO:0036312; GO:0005886; GO:0014068; GO:0034123; GO:0050727; GO:0034134; GO:0034142; GO:0034154; GO:0034162 cytosol; negative regulation of toll-like receptor signaling pathway; phosphatidylinositol 3-kinase regulatory subunit binding; plasma membrane; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of toll-like receptor signaling pathway; regulation of inflammatory response; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 7 signaling pathway; toll-like receptor 9 signaling pathway IPR017893; Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) PIK3AP1 BCAP Homo sapiens (Human) TR41896_c1_g1_i2 Q8NDB2 BANK1_HUMAN 1.00E-14 GO:0042113 B cell activation IPR020683; IPR017893; B-cell scaffold protein with ankyrin repeats BANK1 Homo sapiens (Human) TR41896_c1_g1_i3 Q6ZUJ8 BCAP_HUMAN 3.00E-15 GO:0005829; GO:0034122; GO:0036312; GO:0005886; GO:0014068; GO:0034123; GO:0050727; GO:0034134; GO:0034142; GO:0034154; GO:0034162 cytosol; negative regulation of toll-like receptor signaling pathway; phosphatidylinositol 3-kinase regulatory subunit binding; plasma membrane; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of toll-like receptor signaling pathway; regulation of inflammatory response; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 7 signaling pathway; toll-like receptor 9 signaling pathway IPR017893; Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) PIK3AP1 BCAP Homo sapiens (Human) TR41897_c0_g3_i1 Q6U7I1 UBP7_CHICK 0 GO:0016605; GO:0005737; GO:0007275; GO:0005634; GO:0016579; GO:0051090; GO:0004221; GO:0006511; GO:0004843 PML body; cytoplasm; multicellular organismal development; nucleus; protein deubiquitination; regulation of sequence-specific DNA binding transcription factor activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR002083; IPR018200; IPR001394; IPR008974; IPR024729; Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) USP7 Gallus gallus (Chicken) TR41897_c0_g3_i2 Q9P2H5 UBP35_HUMAN 5.00E-07 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR016024; IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.4.19.12) (Deubiquitinating enzyme 35) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35) USP35 KIAA1372 USP34 Homo sapiens (Human) TR41898_c2_g1_i2 Q6B9X6 VWKA_DICDI 5.00E-11 GO:0005524; GO:0005516; GO:0031164; GO:0000331; GO:0005829; GO:0000281; GO:0031038; GO:0018209; GO:0018107; GO:0048471; GO:0004674; GO:0031156; GO:0031288 ATP binding; calmodulin binding; contractile vacuolar membrane; contractile vacuole; cytosol; mitotic cytokinesis; myosin II filament organization; peptidyl-serine modification; peptidyl-threonine phosphorylation; perinuclear region of cytoplasm; protein serine/threonine kinase activity; regulation of sorocarp development; sorocarp morphogenesis IPR011009; IPR004166; IPR002035; Alpha-protein kinase vwkA (EC 2.7.11.1) (von Willebrand factor A alpha-kinase) (vWF kinase) vwkA DDB_G0268144 Dictyostelium discoideum (Slime mold) TR41898_c2_g1_i6 Q6B9X6 VWKA_DICDI 2.00E-10 GO:0005524; GO:0005516; GO:0031164; GO:0000331; GO:0005829; GO:0000281; GO:0031038; GO:0018209; GO:0018107; GO:0048471; GO:0004674; GO:0031156; GO:0031288 ATP binding; calmodulin binding; contractile vacuolar membrane; contractile vacuole; cytosol; mitotic cytokinesis; myosin II filament organization; peptidyl-serine modification; peptidyl-threonine phosphorylation; perinuclear region of cytoplasm; protein serine/threonine kinase activity; regulation of sorocarp development; sorocarp morphogenesis IPR011009; IPR004166; IPR002035; Alpha-protein kinase vwkA (EC 2.7.11.1) (von Willebrand factor A alpha-kinase) (vWF kinase) vwkA DDB_G0268144 Dictyostelium discoideum (Slime mold) TR41899_c3_g1_i1 Q61555 FBN2_MOUSE 3.00E-27 GO:0060346; GO:0005509; GO:0030326; GO:0005201; GO:0001527; GO:0030501; GO:0045669; GO:0035583 bone trabecula formation; calcium ion binding; embryonic limb morphogenesis; extracellular matrix structural constituent; microfibril; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; sequestering of TGFbeta in extracellular matrix IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR011398; IPR009030; IPR017878; Fibrillin-2 Fbn2 Fbn-2 Mus musculus (Mouse) TR41899_c3_g2_i1 Q96RW7 HMCN1_HUMAN 3.00E-20 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR41899_c3_g2_i10 Q61555 FBN2_MOUSE 0 GO:0060346; GO:0005509; GO:0030326; GO:0005201; GO:0001527; GO:0030501; GO:0045669; GO:0035583 bone trabecula formation; calcium ion binding; embryonic limb morphogenesis; extracellular matrix structural constituent; microfibril; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; sequestering of TGFbeta in extracellular matrix IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR011398; IPR009030; IPR017878; Fibrillin-2 Fbn2 Fbn-2 Mus musculus (Mouse) TR41899_c3_g2_i11 Q14767 LTBP2_HUMAN 7.00E-90 GO:0005509; GO:0005615; GO:0070062; GO:0008201; GO:0009306; GO:0006605; GO:0005578; GO:0007179 Q9UBX5 calcium ion binding; extracellular space; extracellular vesicular exosome; heparin binding; protein secretion; protein targeting; proteinaceous extracellular matrix; transforming growth factor beta receptor signaling pathway IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR017878; Latent-transforming growth factor beta-binding protein 2 (LTBP-2) LTBP2 C14orf141 LTBP3 Homo sapiens (Human) TR41899_c3_g2_i2 O75096 LRP4_HUMAN 5.00E-10 GO:0016055; GO:0005509; GO:0030154; GO:0009953; GO:0042733; GO:0006897; GO:0030198; GO:0001942; GO:0016021; GO:0001822; GO:0090090; GO:0030279; GO:0042475; GO:0005886; GO:0009954; GO:0043113; GO:0001932; GO:0051124 Wnt receptor signaling pathway; calcium ion binding; cell differentiation; dorsal/ventral pattern formation; embryonic digit morphogenesis; endocytosis; extracellular matrix organization; hair follicle development; integral to membrane; kidney development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of ossification; odontogenesis of dentin-containing tooth; plasma membrane; proximal/distal pattern formation; receptor clustering; regulation of protein phosphorylation; synaptic growth at neuromuscular junction IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) TR41899_c3_g2_i3 Q00918 LTBP1_RAT 1.00E-18 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR017878; Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta-1-BP-1) (Transforming growth factor beta-1-masking protein large subunit) Ltbp1 Rattus norvegicus (Rat) TR41899_c3_g2_i5 Q9ESN4 C1QL3_MOUSE 4.00E-07 GO:0005581; GO:0005576; GO:0050807 collagen; extracellular region; regulation of synapse organization IPR001073; IPR008160; IPR008983; Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13) (CTRP13) (Gliacolin) C1ql3 C1ql Ctrp13 Mus musculus (Mouse) TR41899_c3_g2_i9 Q4ZJM9 C1QL4_MOUSE 2.00E-10 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) TR41899_c3_g3_i1 Q9WVH8 FBLN5_RAT 4.00E-34 GO:0005509; GO:0007155; GO:0005737; GO:0071953; GO:0048251; GO:0005615; GO:0034394; GO:0001558; GO:2000121 calcium ion binding; cell adhesion; cytoplasm; elastic fiber; elastic fiber assembly; extracellular space; protein localization to cell surface; regulation of cell growth; regulation of removal of superoxide radicals IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Embryonic vascular EGF repeat-containing protein) (EVEC) Fbln5 Dance Rattus norvegicus (Rat) TR41899_c3_g4_i2 Q9WVJ9 FBLN4_MOUSE 1.00E-34 GO:0007596; GO:0005509; GO:0016020; GO:0005578; GO:0004888 blood coagulation; calcium ion binding; membrane; proteinaceous extracellular matrix; transmembrane signaling receptor activity IPR026823; IPR026824; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001491; EGF-containing fibulin-like extracellular matrix protein 2 (Fibulin-4) (FIBL-4) (Mutant p53-binding protein 1) Efemp2 Fbln4 Mbp1 Mus musculus (Mouse) TR41899_c3_g4_i3 Q62059 CSPG2_MOUSE 1.00E-07 GO:0005509; GO:0030246; GO:0007155; GO:0007507; GO:0005540; GO:0005578; GO:0001657 calcium ion binding; carbohydrate binding; cell adhesion; heart development; hyaluronic acid binding; proteinaceous extracellular matrix; ureteric bud development IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Large fibroblast proteoglycan) (PG-M) Vcan Cspg2 Mus musculus (Mouse) TR41900_c1_g1_i1 P41827 HSP74_ANOAL 0 GO:0005524; GO:0006950 ATP binding; response to stress IPR018181; IPR013126; Heat shock protein 70 B2 HSP70B2 HSP11-C-L Anopheles albimanus (New world malaria mosquito) TR41900_c1_g1_i4 P86237 HS71L_MESAU 2.00E-11 GO:0005524; GO:0006950 ATP binding; response to stress IPR013126; Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Fragments) HSPA1L Mesocricetus auratus (Golden hamster) TR41900_c1_g1_i5 P12077 HSP74_LEIMA 1.00E-79 GO:0005524; GO:0006950 ATP binding; response to stress IPR018181; IPR013126; Heat shock 70-related protein 4 (Fragment) HSP70.4 Leishmania major TR41900_c1_g1_i6 Q05945 HSP70_HYDOL 3.00E-58 GO:0005524; GO:0006950 ATP binding; response to stress IPR018181; IPR013126; Heat shock 70 kDa protein (Fragment) HSP70 Hydra oligactis (Hydra) TR41900_c1_g2_i1 P12794 GRP78_PLAFA 5.00E-42 GO:0005524; GO:0005788; GO:0006950 ATP binding; endoplasmic reticulum lumen; response to stress IPR013126; 78 kDa glucose-regulated protein homolog (GRP-78) (Antigenic heat shock protein 70) (HSP70-2) (Fragment) Plasmodium falciparum TR41900_c1_g3_i1 P02826 HSP7A_DROSI 9.00E-56 GO:0005524; GO:0006950 ATP binding; response to stress IPR018181; IPR013126; Heat shock 70 kDa protein cognate 1 (Heat shock 70 kDa protein 70C) (Fragments) Hsc70-1 Hsc1 Drosophila simulans (Fruit fly) TR41901_c0_g1_i1 Q3UDK1 TRAD1_MOUSE 7.00E-25 GO:0045824; GO:0008270 P70196 negative regulation of innate immune response; zinc ion binding IPR015880; IPR001293; TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) Trafd1 Fln29 Mus musculus (Mouse) TR41901_c0_g1_i2 Q6GPH4 XAF1_HUMAN 2.00E-20 GO:0006915; GO:0005829; GO:0005739; GO:0005634; GO:0035456; GO:0060337; GO:0008270 apoptotic process; cytosol; mitochondrion; nucleus; response to interferon-beta; type I interferon-mediated signaling pathway; zinc ion binding IPR001293; XIAP-associated factor 1 (BIRC4-binding protein) XAF1 BIRC4BP XIAPAF1 Homo sapiens (Human) TR41901_c0_g1_i3 Q3UDK1 TRAD1_MOUSE 7.00E-25 GO:0045824; GO:0008270 P70196 negative regulation of innate immune response; zinc ion binding IPR015880; IPR001293; TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) Trafd1 Fln29 Mus musculus (Mouse) TR41902_c3_g2_i1 Q9NZV5 SELN_HUMAN 1.00E-120 GO:0005509; GO:0005789; GO:0005576 P16333 calcium ion binding; endoplasmic reticulum membrane; extracellular region IPR002048; Selenoprotein N (SelN) SEPN1 SELN Homo sapiens (Human) TR41903_c3_g2_i1 Q4PA36 MON1_USTMA 3.00E-16 GO:0006914; GO:0032585; GO:0015031; GO:0005774 autophagy; multivesicular body membrane; protein transport; vacuolar membrane IPR004353; Vacuolar fusion protein MON1 MON1 UM03027 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR41903_c3_g6_i1 Q86VX9 MON1A_HUMAN 7.00E-159 GO:0006879; GO:0009306 cellular iron ion homeostasis; protein secretion IPR004353; Vacuolar fusion protein MON1 homolog A MON1A SAND1 Homo sapiens (Human) TR41905_c0_g2_i1 O00471 EXOC5_HUMAN 1.00E-62 GO:0044267; GO:0005829; GO:0006887; GO:0006892; GO:0015031; GO:0048278 cellular protein metabolic process; cytosol; exocytosis; post-Golgi vesicle-mediated transport; protein transport; vesicle docking IPR009976; Exocyst complex component 5 (Exocyst complex component Sec10) (hSec10) EXOC5 SEC10 SEC10L1 Homo sapiens (Human) TR41905_c0_g2_i3 Q2QV94 EXOC5_ORYSJ 2.00E-25 GO:0005737; GO:0006887; GO:0015031; GO:0048278 cytoplasm; exocytosis; protein transport; vesicle docking IPR009976; Exocyst complex component 5 (Exocyst complex component Sec10) SEC10 Os12g0238100 LOC_Os12g13590 OSJNBb0001P17 Oryza sativa subsp. japonica (Rice) TR41905_c0_g2_i5 Q8RVQ5 EXOC5_ARATH 9.00E-27 GO:0000145; GO:0006887; GO:0005886; GO:0009506; GO:0015031; GO:0048278 exocyst; exocytosis; plasma membrane; plasmodesma; protein transport; vesicle docking IPR009976; Exocyst complex component SEC10 (AtSec10) (Exocyst complex component 5) SEC10 At5g12370 T2L20.2 Arabidopsis thaliana (Mouse-ear cress) TR41905_c0_g3_i1 Q18406 EXOC5_CAEEL 9.00E-42 GO:0005737; GO:0006887; GO:0015031; GO:0048278 cytoplasm; exocytosis; protein transport; vesicle docking IPR009976; Exocyst complex component 5 (Exocyst complex component Sec10) sec-10 C33H5.9 Caenorhabditis elegans TR41905_c0_g4_i1 P97878 EXOC5_RAT 5.00E-100 GO:0005829; GO:0006887; GO:0015031; GO:0048278 cytosol; exocytosis; protein transport; vesicle docking IPR009976; Exocyst complex component 5 (71 kDa component of rsec6/8 secretory complex) (Exocyst complex component Sec10) (p71) Exoc5 Sec10l1 Rattus norvegicus (Rat) TR41907_c3_g1_i1 Q5XGF1 CENPN_XENTR 4.00E-09 GO:0034508; GO:0007059; GO:0000775; GO:0007067; GO:0005634 "centromere complex assembly; chromosome segregation; chromosome, centromeric region; mitosis; nucleus" IPR027715; IPR007902; Centromere protein N (CENP-N) cenpn TEgg003d08.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41907_c4_g1_i3 Q3T0L2 ERP44_BOVIN 3.00E-12 GO:0045454; GO:0009986; GO:0005788; GO:0005789; GO:0005793; GO:0009100; GO:0003756; GO:0006986 cell redox homeostasis; cell surface; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; glycoprotein metabolic process; protein disulfide isomerase activity; response to unfolded protein IPR012336; IPR013766; Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4) ERP44 TXNDC4 Bos taurus (Bovine) TR41908_c3_g1_i1 Q5PYH7 DLG2_DANRE 0 GO:0010923; GO:0050808; GO:0007268 negative regulation of phosphatase activity; synapse organization; synaptic transmission IPR008145; IPR008144; IPR020590; IPR016313; IPR019590; IPR027417; IPR001478; IPR019583; IPR011511; IPR001452; Disks large homolog 2 (Postsynaptic density protein 93) (PSD-93) dlg2 Danio rerio (Zebrafish) (Brachydanio rerio) TR41908_c3_g1_i3 Q811D0 DLG1_MOUSE 0 GO:0042110; GO:0002369; GO:0007015; GO:0032147; GO:0042982; GO:0016323; GO:0001658; GO:0031253; GO:0005913; GO:0016337; GO:0030866; GO:0048704; GO:0005789; GO:0001935; GO:0060022; GO:0001772; GO:0001771; GO:0043219; GO:0016328; GO:0002088; GO:0045121; GO:0031579; GO:0035748; GO:0042130; GO:0050680; GO:0045930; GO:0031594; GO:0033268; GO:0030432; GO:0019902; GO:0030838; GO:0008284; GO:0048639; GO:0040018; GO:0014069; GO:0045211; GO:0032947; GO:0019901; GO:0008104; GO:0042391; GO:0048608; GO:0048745 Q62108; P06463; Q80TG9; Q810U4 T cell activation; T cell cytokine production; actin filament organization; activation of protein kinase activity; amyloid precursor protein metabolic process; basolateral plasma membrane; branching involved in ureteric bud morphogenesis; cell projection membrane; cell-cell adherens junction; cell-cell adhesion; cortical actin cytoskeleton organization; embryonic skeletal system morphogenesis; endoplasmic reticulum membrane; endothelial cell proliferation; hard palate development; immunological synapse; immunological synapse formation; lateral loop; lateral plasma membrane; lens development in camera-type eye; membrane raft; membrane raft organization; myelin sheath abaxonal region; negative regulation of T cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of mitotic cell cycle; neuromuscular junction; node of Ranvier; peristalsis; phosphatase binding; positive regulation of actin filament polymerization; positive regulation of cell proliferation; positive regulation of developmental growth; positive regulation of multicellular organism growth; postsynaptic density; postsynaptic membrane; protein complex scaffold; protein kinase binding; protein localization; regulation of membrane potential; reproductive structure development; smooth muscle tissue development IPR008145; IPR008144; IPR020590; IPR004172; IPR015143; IPR016313; IPR019590; IPR027417; IPR001478; IPR019583; IPR001452; Disks large homolog 1 (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97) (Synapse-associated protein 97) (SAP-97) (SAP97) Dlg1 Dlgh1 Mus musculus (Mouse) TR41908_c3_g1_i4 Q8TEW0 PARD3_HUMAN 7.00E-18 GO:0003383; GO:0045177; GO:0008356; GO:0044295; GO:0007409; GO:0005938; GO:0007049; GO:0005913; GO:0051642; GO:0005829; GO:0012505; GO:0090162; GO:0000226; GO:0043025; GO:0005547; GO:0032266; GO:0005546; GO:0005886; GO:0006461; GO:0007205; GO:0006612; GO:0032970; GO:0060341; GO:0005819; GO:0005923; GO:0070830; GO:0007179; GO:0044319 P33151; Q9Y624; Q9NPB6; Q9BYG5; Q9JK83; Q9BYG4; Q8ND90; P41743; Q60610; Q6ZPF3; P04637; Q04917; P63104 "apical constriction; apical part of cell; asymmetric cell division; axonal growth cone; axonogenesis; cell cortex; cell cycle; cell-cell adherens junction; centrosome localization; cytosol; endomembrane system; establishment of epithelial cell polarity; microtubule cytoskeleton organization; neuronal cell body; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4,5-bisphosphate binding; plasma membrane; protein complex assembly; protein kinase C-activating G-protein coupled receptor signaling pathway; protein targeting to membrane; regulation of actin filament-based process; regulation of cellular localization; spindle; tight junction; tight junction assembly; transforming growth factor beta receptor signaling pathway; wound healing, spreading of cells" IPR021922; IPR001478; Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) PARD3 PAR3 PAR3A Homo sapiens (Human) TR41908_c3_g1_i5 Q5PYH7 DLG2_DANRE 0 GO:0010923; GO:0050808; GO:0007268 negative regulation of phosphatase activity; synapse organization; synaptic transmission IPR008145; IPR008144; IPR020590; IPR016313; IPR019590; IPR027417; IPR001478; IPR019583; IPR011511; IPR001452; Disks large homolog 2 (Postsynaptic density protein 93) (PSD-93) dlg2 Danio rerio (Zebrafish) (Brachydanio rerio) TR41908_c3_g2_i1 Q9D6K5 SYJ2B_MOUSE 1.00E-17 GO:0009986; GO:0006897; GO:0031307; GO:0048312; GO:0032926; GO:0048471; GO:0032927; GO:2000010; GO:0002092 A2ARV4 cell surface; endocytosis; integral to mitochondrial outer membrane; intracellular distribution of mitochondria; negative regulation of activin receptor signaling pathway; perinuclear region of cytoplasm; positive regulation of activin receptor signaling pathway; positive regulation of protein localization to cell surface; positive regulation of receptor internalization IPR001478; Synaptojanin-2-binding protein (Activin receptor-interacting protein 2) (Activin receptor-interacting protein 4) (Mitochondrial outer membrane protein 25) Synj2bp Arip2 Omp25 Mus musculus (Mouse) TR41908_c3_g2_i2 Q69ZS0 PZRN3_MOUSE 6.00E-10 GO:0031594; GO:0007528; GO:0004842; GO:0008270 neuromuscular junction; neuromuscular junction development; ubiquitin-protein ligase activity; zinc ion binding IPR001478; IPR013323; IPR008974; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase PDZRN3 (EC 6.3.2.-) (PDZ domain-containing RING finger protein 3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) Pdzrn3 Kiaa1095 Semcap3 Mus musculus (Mouse) TR41911_c0_g2_i1 Q5T447 HECD3_HUMAN 0 GO:0005634; GO:0048471; GO:0043161; GO:0042787; GO:0004842 nucleus; perinuclear region of cytoplasm; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR004939; IPR008979; IPR000569; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HECTD3 (EC 6.3.2.-) (HECT domain-containing protein 3) HECTD3 Homo sapiens (Human) TR41911_c0_g2_i3 Q14999 CUL7_HUMAN 6.00E-24 GO:0031467; GO:0005794; GO:0007030; GO:0006987; GO:0005680; GO:0044267; GO:0005829; GO:0019048; GO:0048471; GO:0050775; GO:0016567; GO:0006508; GO:0006511; GO:0001570 P04637 Cul7-RING ubiquitin ligase complex; Golgi apparatus; Golgi organization; activation of signaling protein activity involved in unfolded protein response; anaphase-promoting complex; cellular protein metabolic process; cytosol; modulation by virus of host morphology or physiology; perinuclear region of cytoplasm; positive regulation of dendrite morphogenesis; protein ubiquitination; proteolysis; ubiquitin-dependent protein catabolic process; vasculogenesis IPR004939; IPR016024; IPR021097; IPR016158; IPR001373; IPR008979; IPR014722; Protein modification; protein ubiquitination. Cullin-7 (CUL-7) CUL7 KIAA0076 Homo sapiens (Human) TR41914_c0_g1_i1 P69527 AMPO_RAT 4.00E-30 GO:0004177; GO:0005737; GO:0019370; GO:0008237; GO:0006508; GO:0008270 aminopeptidase activity; cytoplasm; leukotriene biosynthetic process; metallopeptidase activity; proteolysis; zinc ion binding IPR016024; IPR001930; IPR015211; IPR014782; Aminopeptidase O (AP-O) (EC 3.4.11.-) Aopep Onpep Rattus norvegicus (Rat) TR41914_c0_g1_i2 Q8VCT3 AMPB_MOUSE 0 GO:0004177; GO:0005576; GO:0005615; GO:0019370; GO:0008237; GO:0005886; GO:0006508; GO:0008270 aminopeptidase activity; extracellular region; extracellular space; leukotriene biosynthetic process; metallopeptidase activity; plasma membrane; proteolysis; zinc ion binding IPR016024; IPR015571; IPR001930; IPR015211; IPR014782; Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) (Cytosol aminopeptidase IV) Rnpep Mus musculus (Mouse) TR41914_c0_g1_i3 Q9HAU8 RNPL1_HUMAN 1.00E-139 GO:0004177; GO:0019370; GO:0008237; GO:0006508; GO:0008270 aminopeptidase activity; leukotriene biosynthetic process; metallopeptidase activity; proteolysis; zinc ion binding IPR016024; IPR001930; IPR015211; IPR014782; Arginyl aminopeptidase-like 1 (RNPEP-like 1) (EC 3.4.11.-) RNPEPL1 Homo sapiens (Human) TR41914_c0_g1_i4 Q11000 AMPM_HELVI 4.00E-12 GO:0004177; GO:0031225; GO:0008237; GO:0005886; GO:0006508; GO:0008270 aminopeptidase activity; anchored to membrane; metallopeptidase activity; plasma membrane; proteolysis; zinc ion binding IPR024571; IPR001930; IPR014782; Membrane alanyl aminopeptidase (EC 3.4.11.-) (Aminopeptidase N-like protein) (BTBP1) (CryIA(C) receptor) Heliothis virescens (Tobacco budworm moth) TR41914_c0_g2_i4 Q8VCT3 AMPB_MOUSE 9.00E-49 GO:0004177; GO:0005576; GO:0005615; GO:0019370; GO:0008237; GO:0005886; GO:0006508; GO:0008270 aminopeptidase activity; extracellular region; extracellular space; leukotriene biosynthetic process; metallopeptidase activity; plasma membrane; proteolysis; zinc ion binding IPR016024; IPR015571; IPR001930; IPR015211; IPR014782; Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) (Cytosol aminopeptidase IV) Rnpep Mus musculus (Mouse) TR41915_c3_g3_i7 Q5ZKX9 ERD22_CHICK 1.00E-123 GO:0046923; GO:0005789; GO:0016021; GO:0006621; GO:0015031; GO:0016192 ER retention sequence binding; endoplasmic reticulum membrane; integral to membrane; protein retention in ER lumen; protein transport; vesicle-mediated transport IPR000133; ER lumen protein retaining receptor 2 (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2) KDELR2 RCJMB04_8l23 Gallus gallus (Chicken) TR41915_c3_g3_i8 Q5ZKX9 ERD22_CHICK 3.00E-126 GO:0046923; GO:0005789; GO:0016021; GO:0006621; GO:0015031; GO:0016192 ER retention sequence binding; endoplasmic reticulum membrane; integral to membrane; protein retention in ER lumen; protein transport; vesicle-mediated transport IPR000133; ER lumen protein retaining receptor 2 (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2) KDELR2 RCJMB04_8l23 Gallus gallus (Chicken) TR41916_c3_g2_i1 Q56A55 ABCB8_DANRE 0 GO:0005524; GO:0042626; GO:0016021; GO:0005743 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; mitochondrial inner membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; "ATP-binding cassette sub-family B member 8, mitochondrial" abcb8 zgc:113037 Danio rerio (Zebrafish) (Brachydanio rerio) TR41916_c3_g2_i2 Q02592 HMT1_SCHPO 1.00E-74 GO:0005524; GO:0036249; GO:0071276; GO:0071585; GO:0071996; GO:0034634; GO:0071627; GO:0036246; GO:0044604 ATP binding; cadmium ion import into vacuole; cellular response to cadmium ion; detoxification of cadmium ion; glutathione transmembrane import into vacuole; glutathione transmembrane transporter activity; integral to fungal-type vacuolar membrane; phytochelatin 2 import into vacuole; phytochelatin transmembrane transporter ATPase activity IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Heavy metal tolerance protein hmt1 SPCC737.09c SPCC74.08c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41916_c3_g2_i3 Q54W24 ABCB4_DICDI 8.00E-163 GO:0005524; GO:0043190; GO:0042626; GO:0016021; GO:0005739; GO:0031288 "ATP binding; ATP-binding cassette (ABC) transporter complex; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; mitochondrion; sorocarp morphogenesis" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; ABC transporter B family member 4 (ABC transporter ABCB.4) abcB4 DDB_G0279915 Dictyostelium discoideum (Slime mold) TR41916_c3_g2_i4 Q9FNU2 AB25B_ORYSJ 5.00E-46 GO:0005524; GO:0016021; GO:0015421; GO:0000325; GO:0005886; GO:0005774 ATP binding; integral to membrane; oligopeptide-transporting ATPase activity; plant-type vacuole; plasma membrane; vacuolar membrane IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; ABC transporter B family member 25 (ABC transporter ABCB.25) (OsABCB25) (Protein ALS1 homolog) OsABCB25 Os03g0755100 LOC_Os03g54790 OSJNBb0081K01.19 Oryza sativa subsp. japonica (Rice) TR41916_c3_g2_i5 Q56A55 ABCB8_DANRE 4.00E-54 GO:0005524; GO:0042626; GO:0016021; GO:0005743 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; mitochondrial inner membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; "ATP-binding cassette sub-family B member 8, mitochondrial" abcb8 zgc:113037 Danio rerio (Zebrafish) (Brachydanio rerio) TR41918_c1_g2_i1 Q9W5Z5 WSB1_TAKRU 2.00E-89 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR020472; IPR001496; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. WD repeat and SOCS box-containing protein 1 (WSB-1) wsb1 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR41918_c1_g2_i3 Q9Y6I7 WSB1_HUMAN 1.00E-98 GO:0005622; GO:0035556; GO:0016567 Q9QZR5 intracellular; intracellular signal transduction; protein ubiquitination IPR020472; IPR001496; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box-containing WD protein SWiP-1) WSB1 SWIP1 Homo sapiens (Human) TR41918_c1_g2_i5 Q8YV57 Y2124_NOSS1 4.00E-25 GO:0004197; GO:0006508 cysteine-type endopeptidase activity; proteolysis IPR020472; IPR027417; IPR011600; IPR015943; IPR001680; IPR019775; IPR017986; Uncharacterized WD repeat-containing protein all2124 all2124 Nostoc sp. (strain PCC 7120 / UTEX 2576) TR41918_c1_g2_i6 Q9Y6I7 WSB1_HUMAN 7.00E-85 GO:0005622; GO:0035556; GO:0016567 Q9QZR5 intracellular; intracellular signal transduction; protein ubiquitination IPR020472; IPR001496; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box-containing WD protein SWiP-1) WSB1 SWIP1 Homo sapiens (Human) TR41925_c0_g1_i2 Q3UGP9 LRC58_MOUSE 1.00E-68 IPR001611; IPR025875; IPR003591; Leucine-rich repeat-containing protein 58 Lrrc58 Mus musculus (Mouse) TR41925_c0_g1_i3 A4IHG1 LRC58_XENTR 1.00E-77 IPR001611; IPR025875; Leucine-rich repeat-containing protein 58 lrrc58 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41925_c0_g1_i5 A4IHG1 LRC58_XENTR 3.00E-77 IPR001611; IPR025875; Leucine-rich repeat-containing protein 58 lrrc58 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41926_c0_g1_i1 Q9NZN8 CNOT2_HUMAN 3.00E-124 GO:0030014; GO:0001104; GO:0001226; GO:0005829; GO:0031047; GO:0033147; GO:0000122; GO:0000289; GO:0005634; GO:0010606; GO:2000036; GO:0006417; GO:0001829 A5YKK6; O75175; Q9UFF9; Q9HCJ0 CCR4-NOT complex; RNA polymerase II transcription cofactor activity; RNA polymerase II transcription corepressor binding; cytosol; gene silencing by RNA; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nuclear-transcribed mRNA poly(A) tail shortening; nucleus; positive regulation of cytoplasmic mRNA processing body assembly; regulation of stem cell maintenance; regulation of translation; trophectodermal cell differentiation IPR007282; CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2) CNOT2 CDC36 NOT2 HSPC131 MSTP046 Homo sapiens (Human) TR41926_c0_g1_i2 P87240 NOT2_SCHPO 3.00E-26 GO:0030015; GO:0006354; GO:0005829; GO:0000289; GO:0005634; GO:0006357 "CCR4-NOT core complex; DNA-dependent transcription, elongation; cytosol; nuclear-transcribed mRNA poly(A) tail shortening; nucleus; regulation of transcription from RNA polymerase II promoter" IPR007282; General negative regulator of transcription subunit 2 not2 SPCC4G3.15c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41927_c1_g2_i2 P46549 SULU_CAEEL 5.00E-13 GO:0005524; GO:0005938; GO:0007631; GO:0004674; GO:0043051 ATP binding; cell cortex; feeding behavior; protein serine/threonine kinase activity; regulation of pharyngeal pumping IPR011009; IPR000719; IPR017441; IPR002290; Serine/threonine-protein kinase SULU (EC 2.7.11.1) (Protein kinase 18) kin-18 sulu T17E9.1 Caenorhabditis elegans TR41927_c1_g2_i4 P46549 SULU_CAEEL 4.00E-13 GO:0005524; GO:0005938; GO:0007631; GO:0004674; GO:0043051 ATP binding; cell cortex; feeding behavior; protein serine/threonine kinase activity; regulation of pharyngeal pumping IPR011009; IPR000719; IPR017441; IPR002290; Serine/threonine-protein kinase SULU (EC 2.7.11.1) (Protein kinase 18) kin-18 sulu T17E9.1 Caenorhabditis elegans TR41927_c1_g2_i5 Q8RXG3 M2K5_ARATH 4.00E-12 GO:0005524; GO:0009814; GO:0010227; GO:0010229; GO:0009626; GO:0004674; GO:2000037 "ATP binding; defense response, incompatible interaction; floral organ abscission; inflorescence development; plant-type hypersensitive response; protein serine/threonine kinase activity; regulation of stomatal complex patterning" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Mitogen-activated protein kinase kinase 5 (AtMAP2Kalpha) (AtMKK5) (MAP kinase kinase 5) (EC 2.7.12.2) MKK5 At3g21220 MXL8.8 Arabidopsis thaliana (Mouse-ear cress) TR41927_c1_g2_i6 Q6PGN3 DCLK2_MOUSE 7.00E-12 GO:0005524; GO:0005737; GO:0005856; GO:0035556; GO:0004674 ATP binding; cytoplasm; cytoskeleton; intracellular signal transduction; protein serine/threonine kinase activity IPR020636; IPR003533; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) Dclk2 Dcamkl2 Mus musculus (Mouse) TR41929_c0_g1_i2 Q5R9W1 MARH6_PONAB 0 GO:0030176; GO:0016874; GO:0070936; GO:0008270 integral to endoplasmic reticulum membrane; ligase activity; protein K48-linked ubiquitination; zinc ion binding IPR011016; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MARCH6 (EC 6.3.2.-) (Membrane-associated RING finger protein 6) (Membrane-associated RING-CH protein VI) (MARCH-VI) 6-Mar Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41929_c0_g1_i4 Q6ZQ89 MARH6_MOUSE 0 GO:0030176; GO:0070936; GO:0004842; GO:0008270 integral to endoplasmic reticulum membrane; protein K48-linked ubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR011016; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MARCH6 (EC 6.3.2.-) (Membrane-associated RING finger protein 6) (Membrane-associated RING-CH protein VI) (MARCH-VI) March6 Kiaa0597 Mus musculus (Mouse) TR41929_c0_g1_i5 Q6ZQ89 MARH6_MOUSE 0 GO:0030176; GO:0070936; GO:0004842; GO:0008270 integral to endoplasmic reticulum membrane; protein K48-linked ubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR011016; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MARCH6 (EC 6.3.2.-) (Membrane-associated RING finger protein 6) (Membrane-associated RING-CH protein VI) (MARCH-VI) March6 Kiaa0597 Mus musculus (Mouse) TR41929_c0_g1_i6 O60103 DOA10_SCHPO 6.00E-19 GO:0030433; GO:0030176; GO:0004842; GO:0008270 ER-associated protein catabolic process; integral to endoplasmic reticulum membrane; ubiquitin-protein ligase activity; zinc ion binding IPR011016; IPR013083; Protein modification; protein ubiquitination. ERAD-associated E3 ubiquitin-protein ligase doa10 (EC 6.3.2.-) doa10 ssm4 SPBC14F5.07 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41929_c0_g1_i7 Q6ZQ89 MARH6_MOUSE 0 GO:0030176; GO:0070936; GO:0004842; GO:0008270 integral to endoplasmic reticulum membrane; protein K48-linked ubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR011016; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MARCH6 (EC 6.3.2.-) (Membrane-associated RING finger protein 6) (Membrane-associated RING-CH protein VI) (MARCH-VI) March6 Kiaa0597 Mus musculus (Mouse) TR41929_c0_g1_i8 O60103 DOA10_SCHPO 6.00E-19 GO:0030433; GO:0030176; GO:0004842; GO:0008270 ER-associated protein catabolic process; integral to endoplasmic reticulum membrane; ubiquitin-protein ligase activity; zinc ion binding IPR011016; IPR013083; Protein modification; protein ubiquitination. ERAD-associated E3 ubiquitin-protein ligase doa10 (EC 6.3.2.-) doa10 ssm4 SPBC14F5.07 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41931_c0_g1_i1 P0C8G3 UBC_ASFK5 3.00E-13 GO:0005524; GO:0004842 ATP binding; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 (EC 6.3.2.19) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) UBC Ken-155 African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV) TR41931_c0_g1_i2 P52486 UBCD4_DROME 2.00E-78 GO:0005524; GO:0051726; GO:0004842 P55035 ATP binding; regulation of cell cycle; ubiquitin-protein ligase activity IPR009060; IPR015940; IPR000449; IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2-22 kDa (EC 6.3.2.19) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) UbcD4 CG8284 Drosophila melanogaster (Fruit fly) TR41931_c0_g1_i3 P52484 UBC21_CAEEL 2.00E-51 GO:0005524; GO:0004842 ATP binding; ubiquitin-protein ligase activity IPR009060; IPR015940; IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Probable ubiquitin-conjugating enzyme E2 21 (EC 6.3.2.19) (Ubiquitin carrier protein 21) (Ubiquitin-protein ligase 21) ubc-21 C06E2.3 Caenorhabditis elegans TR41932_c1_g2_i1 P41239 CSK_CHICK 0 GO:0005524; GO:0005737; GO:0004715; GO:0018108 ATP binding; cytoplasm; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) CSK Gallus gallus (Chicken) TR41932_c1_g2_i2 P13116 SRC2_XENLA 1.00E-92 GO:0005524; GO:0004715; GO:0018108; GO:0005886 ATP binding; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation; plasma membrane IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2) src-b src2 Xenopus laevis (African clawed frog) TR41932_c1_g2_i4 P05433 GAGC_AVISC 1.00E-07 GO:0019048; GO:0005198; GO:0019028; GO:0019076 modulation by virus of host morphology or physiology; structural molecule activity; viral capsid; viral release from host cell IPR004028; IPR012344; IPR010999; IPR000980; IPR001452; P47(GAG-CRK) protein Avian sarcoma virus (strain CT10) TR41932_c1_g2_i5 P41239 CSK_CHICK 0 GO:0005524; GO:0005737; GO:0004715; GO:0018108 ATP binding; cytoplasm; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) CSK Gallus gallus (Chicken) TR41932_c1_g2_i7 P42690 SRK4_SPOLA 3.00E-100 GO:0005524; GO:0005737; GO:0004715; GO:0018108 ATP binding; cytoplasm; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2) SRK1 Spongilla lacustris (Freshwater sponge) TR41933_c0_g1_i1 Q96MM6 HS12B_HUMAN 3.00E-24 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR41933_c0_g2_i1 Q8K0U4 HS12A_MOUSE 1.00E-39 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR41933_c0_g2_i3 C4L8Y5 DNAK_TOLAT 1.00E-08 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK Tola_2257 Tolumonas auensis (strain DSM 9187 / TA4) TR41933_c0_g2_i4 Q9CZJ2 HS12B_MOUSE 1.00E-60 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR41934_c1_g3_i2 Q7D745 Y2525_MYCTU 5.00E-23 GO:0016021; GO:0016491; GO:0005886 integral to membrane; oxidoreductase activity; plasma membrane IPR016040; IPR005097; Putative trans-acting enoyl reductase MT2525 (EC 1.3.1.-) MT2525 Mycobacterium tuberculosis TR41934_c1_g3_i3 Q8R127 SCPDL_MOUSE 5.00E-128 GO:0005811; GO:0030496; GO:0005739; GO:0016491 lipid particle; midbody; mitochondrion; oxidoreductase activity IPR016040; IPR005097; Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-) Sccpdh Mus musculus (Mouse) TR41934_c1_g3_i4 Q8R127 SCPDL_MOUSE 5.00E-128 GO:0005811; GO:0030496; GO:0005739; GO:0016491 lipid particle; midbody; mitochondrion; oxidoreductase activity IPR016040; IPR005097; Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-) Sccpdh Mus musculus (Mouse) TR41934_c1_g3_i5 Q8LGI2 SCPDL_ARATH 6.00E-86 GO:0009941; GO:0031966; GO:0005739; GO:0016491; GO:0005886; GO:0005774 chloroplast envelope; mitochondrial membrane; mitochondrion; oxidoreductase activity; plasma membrane; vacuolar membrane IPR016040; IPR005097; Probable mitochondrial saccharopine dehydrogenase-like oxidoreductase At5g39410 (SDH) (EC 1.-.-.-) At5g39410 MUL8.9 Arabidopsis thaliana (Mouse-ear cress) TR41935_c0_g1_i1 Q96BD0 SO4A1_HUMAN 5.00E-25 GO:0016021; GO:0005886; GO:0043252; GO:0055085; GO:0005215 integral to membrane; plasma membrane; sodium-independent organic anion transport; transmembrane transport; transporter activity IPR002350; IPR020846; IPR016196; IPR004156; Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) SLCO4A1 OATP1 OATP4A1 OATPE SLC21A12 Homo sapiens (Human) TR41935_c0_g1_i2 Q8K078 SO4A1_MOUSE 4.00E-27 GO:0016021; GO:0006811; GO:0005886; GO:0005215 integral to membrane; ion transport; plasma membrane; transporter activity IPR002350; IPR020846; IPR016196; IPR004156; Solute carrier organic anion transporter family member 4A1 (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) Slco4a1 Oatp4a1 Oatpe Slc21a12 Mus musculus (Mouse) TR41935_c0_g2_i1 Q71MB6 SO4C1_RAT 8.00E-71 GO:0016323; GO:0030154; GO:0016021; GO:0006811; GO:0007275; GO:0007283; GO:0005215 basolateral plasma membrane; cell differentiation; integral to membrane; ion transport; multicellular organismal development; spermatogenesis; transporter activity IPR002350; IPR020846; IPR016196; IPR004156; Solute carrier organic anion transporter family member 4C1 (Solute carrier family 21 member 20) Slco4c1 Oatp4c1 Slc21a20 Rattus norvegicus (Rat) TR41935_c0_g3_i2 Q8HYW2 SO3A1_BOVIN 4.00E-29 GO:0016021; GO:0006811; GO:0005886; GO:0005215 integral to membrane; ion transport; plasma membrane; transporter activity IPR002350; IPR016196; IPR004156; Solute carrier organic anion transporter family member 3A1 (Organic anion-transporting polypeptide D) (OATP-D) SLCO3A1 OATP3A1 OATPD SLC21A11 Bos taurus (Bovine) TR41935_c0_g3_i5 Q8R3L5 SO3A1_MOUSE 6.00E-30 GO:0016021; GO:0006811; GO:0005886; GO:0005215 integral to membrane; ion transport; plasma membrane; transporter activity IPR002350; IPR016196; IPR004156; Solute carrier organic anion transporter family member 3A1 (MJAM) (Organic anion-transporting polypeptide D) (OATP-D) (Sodium-independent organic anion transporter D) (Solute carrier family 21 member 11) Slco3a1 Oatp3a1 Oatpd Slc21a11 Mus musculus (Mouse) TR41937_c2_g2_i1 P35832 PTP99_DROME 3.00E-08 GO:0030424; GO:0007415; GO:0016021; GO:0008045; GO:0005886; GO:0005001 axon; defasciculation of motor neuron axon; integral to membrane; motor neuron axon guidance; plasma membrane; transmembrane receptor protein tyrosine phosphatase activity IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase 99A (EC 3.1.3.48) (Receptor-linked protein-tyrosine phosphatase 99A) (DPTP99A) Ptp99A CG2005 Drosophila melanogaster (Fruit fly) TR41938_c0_g1_i1 Q62703 RCN2_RAT 3.00E-52 GO:0005509; GO:0005788 calcium ion binding; endoplasmic reticulum lumen IPR011992; IPR018247; IPR002048; Reticulocalbin-2 (Calcium-binding protein ERC-55) (Taipoxin-associated calcium-binding protein 49) (TCBP-49) Rcn2 Erc55 Rattus norvegicus (Rat) TR41938_c0_g1_i12 B5X4E0 CALUB_SALSA 5.00E-52 GO:0005509; GO:0005576; GO:0042470; GO:0033018 calcium ion binding; extracellular region; melanosome; sarcoplasmic reticulum lumen IPR027239; IPR011992; IPR018247; IPR002048; Calumenin-B calub Salmo salar (Atlantic salmon) TR41938_c0_g1_i2 Q9NZT1 CALL5_HUMAN 9.00E-06 GO:0005509; GO:0008544; GO:0007165 calcium ion binding; epidermis development; signal transduction IPR011992; IPR018247; IPR002048; Calmodulin-like protein 5 (Calmodulin-like skin protein) CALML5 CLSP Homo sapiens (Human) TR41938_c0_g1_i4 O35887 CALU_MOUSE 6.00E-54 GO:0005509; GO:0005788; GO:0005576; GO:0042470; GO:0033018 calcium ion binding; endoplasmic reticulum lumen; extracellular region; melanosome; sarcoplasmic reticulum lumen IPR027239; IPR011992; IPR018247; IPR002048; Calumenin (Crocalbin) Calu Mus musculus (Mouse) TR41938_c0_g1_i6 Q66JA6 CAB45_XENLA 6.00E-21 GO:0005796; GO:0005509 Golgi lumen; calcium ion binding IPR027240; IPR011992; IPR018247; IPR002048; 45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4) sdf4 cab45 Xenopus laevis (African clawed frog) TR41938_c0_g1_i7 Q3T0K1 CALU_BOVIN 1.00E-52 GO:0005509; GO:0005576; GO:0042470; GO:0033018 calcium ion binding; extracellular region; melanosome; sarcoplasmic reticulum lumen IPR027239; IPR011992; IPR018247; IPR002048; Calumenin CALU Bos taurus (Bovine) TR41938_c0_g1_i8 O35887 CALU_MOUSE 3.00E-56 GO:0005509; GO:0005788; GO:0005576; GO:0042470; GO:0033018 calcium ion binding; endoplasmic reticulum lumen; extracellular region; melanosome; sarcoplasmic reticulum lumen IPR027239; IPR011992; IPR018247; IPR002048; Calumenin (Crocalbin) Calu Mus musculus (Mouse) TR41939_c2_g1_i1 Q9ESJ0 XPO4_MOUSE 0 GO:0005737; GO:0005634; GO:0046827; GO:0015031 cytoplasm; nucleus; positive regulation of protein export from nucleus; protein transport IPR016024; IPR014877; Exportin-4 (Exp4) Xpo4 Kiaa1721 Mus musculus (Mouse) TR41939_c2_g2_i3 Q54UP5 XPO4_DICDI 8.00E-34 GO:0005737; GO:0005634; GO:0015031 cytoplasm; nucleus; protein transport IPR016024; Exportin-4 (Exp4) xpo4 DDB_G0280907 Dictyostelium discoideum (Slime mold) TR41941_c5_g1_i1 Q8VEB2 SAV1_MOUSE 6.00E-53 GO:0005737; GO:0001942; GO:0035329; GO:0060575; GO:0030216; GO:0060487; GO:0060044; GO:0050680; GO:0005634; GO:0043065; GO:2000036; GO:0060412 cytoplasm; hair follicle development; hippo signaling cascade; intestinal epithelial cell differentiation; keratinocyte differentiation; lung epithelial cell differentiation; negative regulation of cardiac muscle cell proliferation; negative regulation of epithelial cell proliferation; nucleus; positive regulation of apoptotic process; regulation of stem cell maintenance; ventricular septum morphogenesis IPR011524; IPR001202; Protein salvador homolog 1 (45 kDa WW domain protein) (mWW45) Sav1 Ww45 Wwp3 Mus musculus (Mouse) TR41942_c1_g1_i1 Q8IY33 MILK2_HUMAN 2.00E-51 GO:0031532; GO:0051015; GO:0032432; GO:0030041; GO:0005829; GO:0032456; GO:0006897; GO:0031005; GO:0043005; GO:0031175; GO:0005886; GO:0055037; GO:0034446; GO:0005923; GO:0070830; GO:0008270 actin cytoskeleton reorganization; actin filament binding; actin filament bundle; actin filament polymerization; cytosol; endocytic recycling; endocytosis; filamin binding; neuron projection; neuron projection development; plasma membrane; recycling endosome; substrate adhesion-dependent cell spreading; tight junction; tight junction assembly; zinc ion binding IPR001715; IPR022735; IPR001781; MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) MICALL2 JRAB Homo sapiens (Human) TR41942_c1_g1_i3 Q8IY33 MILK2_HUMAN 9.00E-52 GO:0031532; GO:0051015; GO:0032432; GO:0030041; GO:0005829; GO:0032456; GO:0006897; GO:0031005; GO:0043005; GO:0031175; GO:0005886; GO:0055037; GO:0034446; GO:0005923; GO:0070830; GO:0008270 actin cytoskeleton reorganization; actin filament binding; actin filament bundle; actin filament polymerization; cytosol; endocytic recycling; endocytosis; filamin binding; neuron projection; neuron projection development; plasma membrane; recycling endosome; substrate adhesion-dependent cell spreading; tight junction; tight junction assembly; zinc ion binding IPR001715; IPR022735; IPR001781; MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) MICALL2 JRAB Homo sapiens (Human) TR41942_c1_g1_i4 F6QZ15 MICA2_XENTR 7.00E-27 GO:0071949; GO:0003779; GO:0030042; GO:0005737; GO:0005856; GO:0016709; GO:0019417; GO:0008270 "FAD binding; actin binding; actin filament depolymerization; cytoplasm; cytoskeleton; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; sulfur oxidation; zinc ion binding" IPR001715; IPR002938; IPR001781; Protein-methionine sulfoxide oxidase mical2 (EC 1.14.13.-) (Molecule interacting with CasL protein 2) (MICAL-2) mical2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41943_c3_g1_i5 P34237 CASP_YEAST 4.00E-14 GO:0000139; GO:0048193; GO:0030173; GO:0006891 Golgi membrane; Golgi vesicle transport; integral to Golgi membrane; intra-Golgi vesicle-mediated transport IPR012955; Protein CASP COY1 YKL179C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41943_c3_g2_i1 Q9LS42 CASP_ARATH 2.00E-23 GO:0005794; GO:0005768; GO:0030173; GO:0016021; GO:0006891; GO:0005802 Golgi apparatus; endosome; integral to Golgi membrane; integral to membrane; intra-Golgi vesicle-mediated transport; trans-Golgi network IPR012955; Protein CASP CASP At3g18480 MYF24.37 Arabidopsis thaliana (Mouse-ear cress) TR41943_c3_g2_i2 Q5R8V1 CASP_PONAB 3.00E-78 GO:0030173; GO:0006891 integral to Golgi membrane; intra-Golgi vesicle-mediated transport IPR012955; Protein CASP CUTL1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41943_c3_g2_i3 P39880 CUX1_HUMAN 4.00E-72 GO:0000139; GO:0042491; GO:0003682; GO:0005829; GO:0001822; GO:0030324; GO:0007275; GO:0000122; GO:0005634; GO:0000301; GO:0043565; GO:0003700; GO:0006351 "Golgi membrane; auditory receptor cell differentiation; chromatin binding; cytosol; kidney development; lung development; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; nucleus; retrograde transport, vesicle recycling within Golgi; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR003350; IPR017970; IPR001356; IPR009057; IPR010982; Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein cux-1) CUX1 CUTL1 Homo sapiens (Human) TR41944_c0_g1_i2 Q8K4P0 WDR33_MOUSE 1.00E-11 GO:0005581; GO:0006397; GO:0005634 collagen; mRNA processing; nucleus IPR008160; IPR015943; IPR001680; IPR017986; pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein WDC146) Wdr33 Wdc146 Mus musculus (Mouse) TR41944_c0_g3_i2 Q9C0J8 WDR33_HUMAN 2.00E-87 GO:0005581; GO:0006397; GO:0005634; GO:0006301; GO:0007283 collagen; mRNA processing; nucleus; postreplication repair; spermatogenesis IPR008160; IPR015943; IPR001680; IPR017986; pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein WDC146) WDR33 WDC146 Homo sapiens (Human) TR41945_c6_g2_i1 Q00963 SPTCB_DROME 0 GO:0003779; GO:0051693; GO:0030506; GO:0016327; GO:0030424; GO:0016199; GO:0045169; GO:0045478; GO:0016328; GO:0005811; GO:0042062; GO:0048790; GO:0008017; GO:0007026; GO:0031594; GO:0007274; GO:0005546; GO:0072499; GO:0007009; GO:0008091; GO:0045170; GO:0030721; GO:0005200 "actin binding; actin filament capping; ankyrin binding; apicolateral plasma membrane; axon; axon midline choice point recognition; fusome; fusome organization; lateral plasma membrane; lipid particle; long-term strengthening of neuromuscular junction; maintenance of presynaptic active zone structure; microtubule binding; negative regulation of microtubule depolymerization; neuromuscular junction; neuromuscular synaptic transmission; phosphatidylinositol-4,5-bisphosphate binding; photoreceptor cell axon guidance; plasma membrane organization; spectrin; spectrosome; spectrosome organization; structural constituent of cytoskeleton" IPR001589; IPR001715; IPR001605; IPR011993; IPR001849; IPR018159; IPR016343; IPR002017; Spectrin beta chain beta-Spec Spec-b CG5870 Drosophila melanogaster (Fruit fly) TR41945_c6_g2_i2 Q00963 SPTCB_DROME 0 GO:0003779; GO:0051693; GO:0030506; GO:0016327; GO:0030424; GO:0016199; GO:0045169; GO:0045478; GO:0016328; GO:0005811; GO:0042062; GO:0048790; GO:0008017; GO:0007026; GO:0031594; GO:0007274; GO:0005546; GO:0072499; GO:0007009; GO:0008091; GO:0045170; GO:0030721; GO:0005200 "actin binding; actin filament capping; ankyrin binding; apicolateral plasma membrane; axon; axon midline choice point recognition; fusome; fusome organization; lateral plasma membrane; lipid particle; long-term strengthening of neuromuscular junction; maintenance of presynaptic active zone structure; microtubule binding; negative regulation of microtubule depolymerization; neuromuscular junction; neuromuscular synaptic transmission; phosphatidylinositol-4,5-bisphosphate binding; photoreceptor cell axon guidance; plasma membrane organization; spectrin; spectrosome; spectrosome organization; structural constituent of cytoskeleton" IPR001589; IPR001715; IPR001605; IPR011993; IPR001849; IPR018159; IPR016343; IPR002017; Spectrin beta chain beta-Spec Spec-b CG5870 Drosophila melanogaster (Fruit fly) TR41945_c6_g2_i4 Q13813 SPTN1_HUMAN 3.00E-132 GO:0030018; GO:0003779; GO:0051693; GO:0007411; GO:0005509; GO:0006921; GO:0032437; GO:0005829; GO:0005916; GO:0043231; GO:0016328; GO:0016020; GO:0015630; GO:0008091; GO:0005200 Q9UI08; O15287; P40692; Q01082 Z disc; actin binding; actin filament capping; axon guidance; calcium ion binding; cellular component disassembly involved in execution phase of apoptosis; cuticular plate; cytosol; fascia adherens; intracellular membrane-bounded organelle; lateral plasma membrane; membrane; microtubule cytoskeleton; spectrin; structural constituent of cytoskeleton IPR011992; IPR014837; IPR018247; IPR002048; IPR001452; IPR018159; IPR013315; IPR002017; "Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)" SPTAN1 NEAS SPTA2 Homo sapiens (Human) TR41945_c6_g2_i5 Q00963 SPTCB_DROME 0 GO:0003779; GO:0051693; GO:0030506; GO:0016327; GO:0030424; GO:0016199; GO:0045169; GO:0045478; GO:0016328; GO:0005811; GO:0042062; GO:0048790; GO:0008017; GO:0007026; GO:0031594; GO:0007274; GO:0005546; GO:0072499; GO:0007009; GO:0008091; GO:0045170; GO:0030721; GO:0005200 "actin binding; actin filament capping; ankyrin binding; apicolateral plasma membrane; axon; axon midline choice point recognition; fusome; fusome organization; lateral plasma membrane; lipid particle; long-term strengthening of neuromuscular junction; maintenance of presynaptic active zone structure; microtubule binding; negative regulation of microtubule depolymerization; neuromuscular junction; neuromuscular synaptic transmission; phosphatidylinositol-4,5-bisphosphate binding; photoreceptor cell axon guidance; plasma membrane organization; spectrin; spectrosome; spectrosome organization; structural constituent of cytoskeleton" IPR001589; IPR001715; IPR001605; IPR011993; IPR001849; IPR018159; IPR016343; IPR002017; Spectrin beta chain beta-Spec Spec-b CG5870 Drosophila melanogaster (Fruit fly) TR41945_c6_g2_i6 Q00963 SPTCB_DROME 9.00E-143 GO:0003779; GO:0051693; GO:0030506; GO:0016327; GO:0030424; GO:0016199; GO:0045169; GO:0045478; GO:0016328; GO:0005811; GO:0042062; GO:0048790; GO:0008017; GO:0007026; GO:0031594; GO:0007274; GO:0005546; GO:0072499; GO:0007009; GO:0008091; GO:0045170; GO:0030721; GO:0005200 "actin binding; actin filament capping; ankyrin binding; apicolateral plasma membrane; axon; axon midline choice point recognition; fusome; fusome organization; lateral plasma membrane; lipid particle; long-term strengthening of neuromuscular junction; maintenance of presynaptic active zone structure; microtubule binding; negative regulation of microtubule depolymerization; neuromuscular junction; neuromuscular synaptic transmission; phosphatidylinositol-4,5-bisphosphate binding; photoreceptor cell axon guidance; plasma membrane organization; spectrin; spectrosome; spectrosome organization; structural constituent of cytoskeleton" IPR001589; IPR001715; IPR001605; IPR011993; IPR001849; IPR018159; IPR016343; IPR002017; Spectrin beta chain beta-Spec Spec-b CG5870 Drosophila melanogaster (Fruit fly) TR41945_c6_g3_i1 Q01082 SPTB2_HUMAN 1.00E-143 GO:0043001; GO:0031430; GO:0007184; GO:0003779; GO:0051693; GO:0030506; GO:0030673; GO:0007411; GO:0007182; GO:0032437; GO:0005829; GO:0071709; GO:0000281; GO:0005730; GO:0005543; GO:0072661; GO:0008091; GO:0014731; GO:0005200 Q9NRI5; P02549; Q13813 Golgi to plasma membrane protein transport; M band; SMAD protein import into nucleus; actin binding; actin filament capping; ankyrin binding; axolemma; axon guidance; common-partner SMAD protein phosphorylation; cuticular plate; cytosol; membrane assembly; mitotic cytokinesis; nucleolus; phospholipid binding; protein targeting to plasma membrane; spectrin; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR001589; IPR001715; IPR001605; IPR011993; IPR001849; IPR018159; IPR016343; IPR002017; "Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)" SPTBN1 SPTB2 Homo sapiens (Human) TR41945_c6_g3_i3 Q5RCS6 ACTN4_PONAB 3.00E-85 GO:0005509; GO:0030054; GO:0005737; GO:0005634; GO:0015031; GO:0030529 calcium ion binding; cell junction; cytoplasm; nucleus; protein transport; ribonucleoprotein complex IPR001589; IPR001715; IPR011992; IPR014837; IPR018247; IPR002048; IPR018159; IPR002017; Alpha-actinin-4 (F-actin cross-linking protein) (Non-muscle alpha-actinin 4) ACTN4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41947_c1_g1_i1 Q6WRI0 IGS10_HUMAN 3.00E-09 GO:0030154; GO:0005576; GO:0007275; GO:0001503 cell differentiation; extracellular region; multicellular organismal development; ossification IPR000483; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR003591; IPR000372; Immunoglobulin superfamily member 10 (IgSF10) (Calvaria mechanical force protein 608) (CMF608) IGSF10 CMF608 Homo sapiens (Human) TR41947_c1_g1_i2 O89103 C1QR1_MOUSE 8.00E-07 GO:0005509; GO:0030246; GO:0009986; GO:0016337; GO:0016023; GO:0016021; GO:0005886 calcium ion binding; carbohydrate binding; cell surface; cell-cell adhesion; cytoplasmic membrane-bounded vesicle; integral to membrane; plasma membrane IPR001304; IPR016186; IPR016187; IPR016316; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Complement component C1q receptor (C1q/MBL/SPA receptor) (C1qR(p)) (C1qRp) (Cell surface antigen AA4) (Complement component 1 q subcomponent receptor 1) (Lymphocyte antigen 68) (Ly-68) (CD antigen CD93) Cd93 Aa4 C1qr1 C1qrp Ly68 Mus musculus (Mouse) TR41947_c1_g2_i2 Q9HAR2 LPHN3_HUMAN 9.00E-67 GO:0004930; GO:0030246; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; carbohydrate binding; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR001879; IPR003924; IPR015630; IPR003334; IPR000832; IPR017983; IPR000203; IPR000922; IPR003112; Latrophilin-3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Lectomedin-3) LPHN3 KIAA0768 LEC3 Homo sapiens (Human) TR41948_c2_g3_i1 Q6P8G1 ILF2_XENTR 1.00E-109 GO:0005524; GO:0003677; GO:0003725; GO:0006955; GO:0005730; GO:0045893; GO:0006351; GO:0016740 "ATP binding; DNA binding; double-stranded RNA binding; immune response; nucleolus; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; transferase activity" IPR006116; IPR006561; Interleukin enhancer-binding factor 2 homolog ilf2 TEgg021l09.1 TEgg033l23.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41950_c0_g1_i1 Q09912 PSI1_SCHPO 2.00E-39 GO:0030544; GO:0007049; GO:0034605; GO:0002183; GO:0005829; GO:0005634; GO:0006457 Hsp70 protein binding; cell cycle; cellular response to heat; cytoplasmic translational initiation; cytosol; nucleus; protein folding IPR002939; IPR001623; IPR018253; IPR008971; Protein psi1 (Protein psi) psi1 psi SPCC830.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41950_c0_g1_i2 Q9UDY4 DNJB4_HUMAN 2.00E-118 GO:0005737; GO:0005634; GO:0005886; GO:0006457; GO:0009408; GO:0006986; GO:0051082 cytoplasm; nucleus; plasma membrane; protein folding; response to heat; response to unfolded protein; unfolded protein binding IPR002939; IPR001623; IPR018253; IPR008971; DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein) DNAJB4 DNAJW HLJ1 Homo sapiens (Human) TR41950_c0_g1_i3 Q09912 PSI1_SCHPO 2.00E-39 GO:0030544; GO:0007049; GO:0034605; GO:0002183; GO:0005829; GO:0005634; GO:0006457 Hsp70 protein binding; cell cycle; cellular response to heat; cytoplasmic translational initiation; cytosol; nucleus; protein folding IPR002939; IPR001623; IPR018253; IPR008971; Protein psi1 (Protein psi) psi1 psi SPCC830.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41950_c0_g1_i4 Q8N7S2 DNJ5G_HUMAN 1.00E-08 GO:0016020 membrane IPR001623; IPR018253; DnaJ homolog subfamily C member 5G (Cysteine string protein-gamma) (CSP-gamma) DNAJC5G Homo sapiens (Human) TR41950_c0_g1_i5 Q5R9A4 DNJB9_PONAB 1.00E-19 GO:0030433; GO:0005783; GO:0005788 ER-associated protein catabolic process; endoplasmic reticulum; endoplasmic reticulum lumen IPR001623; IPR018253; DnaJ homolog subfamily B member 9 DNAJB9 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR41950_c0_g1_i6 Q9UDY4 DNJB4_HUMAN 1.00E-119 GO:0005737; GO:0005634; GO:0005886; GO:0006457; GO:0009408; GO:0006986; GO:0051082 cytoplasm; nucleus; plasma membrane; protein folding; response to heat; response to unfolded protein; unfolded protein binding IPR002939; IPR001623; IPR018253; IPR008971; DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein) DNAJB4 DNAJW HLJ1 Homo sapiens (Human) TR41950_c0_g1_i7 O89114 DNJB5_MOUSE 1.00E-119 GO:0005829; GO:0000122; GO:0005634; GO:0006457; GO:0006986; GO:0051082 cytosol; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein folding; response to unfolded protein; unfolded protein binding IPR002939; IPR001623; IPR018253; IPR008971; DnaJ homolog subfamily B member 5 (Heat shock protein Hsp40-3) (Heat shock protein cognate 40) (Hsc40) Dnajb5 Hsc40 Mus musculus (Mouse) TR41950_c0_g1_i8 O89114 DNJB5_MOUSE 3.00E-119 GO:0005829; GO:0000122; GO:0005634; GO:0006457; GO:0006986; GO:0051082 cytosol; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein folding; response to unfolded protein; unfolded protein binding IPR002939; IPR001623; IPR018253; IPR008971; DnaJ homolog subfamily B member 5 (Heat shock protein Hsp40-3) (Heat shock protein cognate 40) (Hsc40) Dnajb5 Hsc40 Mus musculus (Mouse) TR41950_c0_g1_i9 Q9D832 DNJB4_MOUSE 4.00E-118 GO:0006457 protein folding IPR002939; IPR001623; IPR018253; IPR008971; DnaJ homolog subfamily B member 4 Dnajb4 Mus musculus (Mouse) TR41952_c3_g4_i1 Q99996 AKAP9_HUMAN 9.00E-15 GO:0000086; GO:0005794; GO:0005813; GO:0005829; GO:0000242; GO:0032947; GO:0005102; GO:0007165; GO:0007268; GO:0006810; GO:0008076 Q08379; O60341 G2/M transition of mitotic cell cycle; Golgi apparatus; centrosome; cytosol; pericentriolar material; protein complex scaffold; receptor binding; signal transduction; synaptic transmission; transport; voltage-gated potassium channel complex IPR019528; A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) TR41952_c3_g5_i1 Q70FJ1 AKAP9_MOUSE 5.00E-20 GO:0005794; GO:0000242 Golgi apparatus; pericentriolar material IPR019528; A-kinase anchor protein 9 (AKAP-9) (Protein kinase A-anchoring protein 9) (PRKA9) Akap9 Kiaa0803 Mus musculus (Mouse) TR41952_c3_g7_i1 Q99996 AKAP9_HUMAN 4.00E-13 GO:0000086; GO:0005794; GO:0005813; GO:0005829; GO:0000242; GO:0032947; GO:0005102; GO:0007165; GO:0007268; GO:0006810; GO:0008076 Q08379; O60341 G2/M transition of mitotic cell cycle; Golgi apparatus; centrosome; cytosol; pericentriolar material; protein complex scaffold; receptor binding; signal transduction; synaptic transmission; transport; voltage-gated potassium channel complex IPR019528; A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) TR41953_c1_g1_i2 P50516 VATA_MOUSE 0 GO:0005524; GO:0015991; GO:0016324; GO:0005829; GO:0005902; GO:0005739; GO:0046961; GO:0033180 "ATP binding; ATP hydrolysis coupled proton transport; apical plasma membrane; cytosol; microvillus; mitochondrion; proton-transporting ATPase activity, rotational mechanism; proton-transporting V-type ATPase, V1 domain" IPR020003; IPR000793; IPR000194; IPR004100; IPR024034; IPR005725; IPR027417; IPR022878; V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 3.6.3.14) (V-ATPase 69 kDa subunit) (Vacuolar proton pump subunit alpha) Atp6v1a Atp6a1 Atp6a2 Atp6v1a1 Mus musculus (Mouse) TR41953_c1_g1_i4 Q27331 VATA2_DROME 9.00E-66 GO:0005524; GO:0015991; GO:0048388; GO:0016197; GO:0007446; GO:0033181; GO:0046961; GO:0000221 "ATP binding; ATP hydrolysis coupled proton transport; endosomal lumen acidification; endosomal transport; imaginal disc growth; plasma membrane proton-transporting V-type ATPase complex; proton-transporting ATPase activity, rotational mechanism; vacuolar proton-transporting V-type ATPase, V1 domain" IPR020003; IPR000793; IPR000194; IPR004100; IPR024034; IPR005725; IPR027417; IPR022878; V-type proton ATPase catalytic subunit A isoform 2 (V-ATPase subunit A 2) (EC 3.6.3.14) (V-ATPase 69 kDa subunit 2) (Vacuolar proton pump subunit alpha 2) Vha68-2 VHAA2 CG3762 Drosophila melanogaster (Fruit fly) TR41954_c0_g1_i2 O75592 MYCB2_HUMAN 3.00E-115 GO:0030424; GO:0021785; GO:0021952; GO:0015630; GO:0005634; GO:0051493; GO:0032880; GO:0006355; GO:0006351; GO:0004842; GO:0008270 Q99IB8 "axon; branchiomotor neuron axon guidance; central nervous system projection neuron axonogenesis; microtubule cytoskeleton; nucleus; regulation of cytoskeleton organization; regulation of protein localization; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR004939; IPR017868; IPR008979; IPR027047; IPR013783; IPR014756; IPR012983; IPR009091; IPR000408; IPR003646; IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc) MYCBP2 KIAA0916 PAM Homo sapiens (Human) TR41955_c0_g1_i2 Q6R5N8 TLR13_MOUSE 1.00E-11 GO:0002755; GO:0005768; GO:0010008; GO:0006954; GO:0045087; GO:0016021; GO:0042803; GO:0019843; GO:0043408; GO:0002237; GO:0009615; GO:0034178; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; endosome; endosome membrane; inflammatory response; innate immune response; integral to membrane; protein homodimerization activity; rRNA binding; regulation of MAPK cascade; response to molecule of bacterial origin; response to virus; toll-like receptor 13 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR003591; IPR000157; IPR027196; Toll-like receptor 13 Tlr13 Mus musculus (Mouse) TR41955_c0_g1_i3 Q9BE71 LRFN2_MACFA 5.00E-07 GO:0030054; GO:0016021; GO:0045211 cell junction; integral to membrane; postsynaptic membrane IPR000483; IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeat and fibronectin type-III domain-containing protein 2 LRFN2 SALM1 QflA-11865 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR41955_c0_g1_i4 Q8BXA0 LRFN5_MOUSE 5.00E-09 GO:0016021 integral to membrane IPR000483; IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR026879; IPR000372; IPR026906; Leucine-rich repeat and fibronectin type-III domain-containing protein 5 Lrfn5 Kiaa4208 Salm5 Mus musculus (Mouse) TR41955_c0_g1_i5 B0BNK7 LRFN3_RAT 4.00E-06 GO:0030424; GO:0007155; GO:0030054; GO:0030425; GO:0016021; GO:0045211; GO:0042734 axon; cell adhesion; cell junction; dendrite; integral to membrane; postsynaptic membrane; presynaptic membrane IPR000483; IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR003591; IPR000372; Leucine-rich repeat and fibronectin type-III domain-containing protein 3 (Synaptic adhesion-like molecule 4) Lrfn3 Salm4 Rattus norvegicus (Rat) TR41955_c0_g2_i1 Q9JLF7 TLR5_MOUSE 1.00E-09 GO:0002755; GO:0042742; GO:0006954; GO:0045087; GO:0016021; GO:0001819; GO:0050707; GO:0034146; GO:0004888 Q56086; E1WGJ5 MyD88-dependent toll-like receptor signaling pathway; defense response to bacterium; inflammatory response; innate immune response; integral to membrane; positive regulation of cytokine production; regulation of cytokine secretion; toll-like receptor 5 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027176; Toll-like receptor 5 Tlr5 Mus musculus (Mouse) TR41955_c0_g2_i2 Q6R5N8 TLR13_MOUSE 3.00E-12 GO:0002755; GO:0005768; GO:0010008; GO:0006954; GO:0045087; GO:0016021; GO:0042803; GO:0019843; GO:0043408; GO:0002237; GO:0009615; GO:0034178; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; endosome; endosome membrane; inflammatory response; innate immune response; integral to membrane; protein homodimerization activity; rRNA binding; regulation of MAPK cascade; response to molecule of bacterial origin; response to virus; toll-like receptor 13 signaling pathway; transmembrane signaling receptor activity IPR001611; IPR003591; IPR000157; IPR027196; Toll-like receptor 13 Tlr13 Mus musculus (Mouse) TR41955_c0_g2_i3 P08953 TOLL_DROME 7.00E-13 GO:0033565; GO:0008063; GO:0019732; GO:0007155; GO:0019955; GO:0050830; GO:0005769; GO:0009897; GO:0007507; GO:0035172; GO:0030097; GO:0045087; GO:0016021; GO:0006963; GO:0006967; GO:0045610; GO:0007416; GO:0016201; GO:0004888; GO:0007352 Itself; Q7K105 ESCRT-0 complex; Toll signaling pathway; antifungal humoral response; cell adhesion; cytokine binding; defense response to Gram-positive bacterium; early endosome; external side of plasma membrane; heart development; hemocyte proliferation; hemopoiesis; innate immune response; integral to membrane; positive regulation of antibacterial peptide biosynthetic process; positive regulation of antifungal peptide biosynthetic process; regulation of hemocyte differentiation; synapse assembly; synaptic target inhibition; transmembrane signaling receptor activity; zygotic specification of dorsal/ventral axis IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) TR41956_c4_g3_i1 Q9RUW8 RO60_DEIRA 3.00E-34 GO:0003723; GO:0005737; GO:0046872; GO:0030529 RNA binding; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein homolog (Ro sixty-related protein) rsr DR_1262 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) TR41956_c4_g3_i2 O08848 RO60_MOUSE 5.00E-33 GO:0003723; GO:0060271; GO:0005737; GO:0046872; GO:0030529 RNA binding; cilium morphogenesis; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) Trove2 Ssa2 Mus musculus (Mouse) TR41956_c4_g3_i3 Q27274 RO60_CAEEL 3.00E-33 GO:0003723; GO:0005737; GO:0046872; GO:0030529 RNA binding; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein homolog rop-1 C12D8.11 Caenorhabditis elegans TR41956_c4_g3_i5 P10155 RO60_HUMAN 3.00E-36 GO:0003723; GO:0060271; GO:0005737; GO:0046872; GO:0005634; GO:0030529; GO:0006383 Q9UHX1 RNA binding; cilium morphogenesis; cytoplasm; metal ion binding; nucleus; ribonucleoprotein complex; transcription from RNA polymerase III promoter IPR008858; IPR018698; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) TR41956_c4_g3_i6 P42700 RO60_XENLA 1.00E-29 GO:0003723; GO:0030030; GO:0005737; GO:0046872; GO:0030529 RNA binding; cell projection organization; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) trove2 Xenopus laevis (African clawed frog) TR41956_c4_g3_i9 Q9RUW8 RO60_DEIRA 2.00E-33 GO:0003723; GO:0005737; GO:0046872; GO:0030529 RNA binding; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein homolog (Ro sixty-related protein) rsr DR_1262 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) TR41958_c1_g4_i1 Q7M3S9 RNGB_DICDI 5.00E-11 GO:0005737; GO:0008270 cytoplasm; zinc ion binding IPR015915; IPR006652; IPR001841; IPR013083; RING finger protein B (Protein rngB) rngB DDB_G0268860 Dictyostelium discoideum (Slime mold) TR41958_c1_g4_i2 Q05AK5 MYLIB_DANRE 4.00E-08 GO:0005737; GO:0005856; GO:0005829; GO:0007369; GO:0016874; GO:0030178; GO:0016567; GO:0008270 cytoplasm; cytoskeleton; cytosol; gastrulation; ligase activity; negative regulation of Wnt receptor signaling pathway; protein ubiquitination; zinc ion binding IPR019749; IPR019750; IPR014352; IPR019748; IPR000299; IPR018979; IPR011993; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MYLIP-B (EC 6.3.2.-) (Myosin regulatory light chain-interacting protein B) (MIR-B) mylipb zgc:153767 Danio rerio (Zebrafish) (Brachydanio rerio) TR41958_c1_g5_i1 Q804S5 MIB1_DANRE 3.00E-08 GO:0007219; GO:0005737; GO:0007275; GO:0005886; GO:0004842; GO:0008270 Notch signaling pathway; cytoplasm; multicellular organismal development; plasma membrane; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase mib1 (EC 6.3.2.-) (Protein mind bomb) mib1 mib Danio rerio (Zebrafish) (Brachydanio rerio) TR41958_c1_g8_i1 Q8JGN5 BI51A_XENLA 8.00E-08 GO:0051301; GO:0032133; GO:0007059; GO:0000777; GO:0005737; GO:0046872; GO:0030496; GO:0007067; GO:0043066; GO:0045892; GO:0005634; GO:0006468; GO:0005819; GO:0051225 "cell division; chromosome passenger complex; chromosome segregation; condensed chromosome kinetochore; cytoplasm; metal ion binding; midbody; mitosis; negative regulation of apoptotic process; negative regulation of transcription, DNA-dependent; nucleus; protein phosphorylation; spindle; spindle assembly" IPR001370; Baculoviral IAP repeat-containing protein 5.1-A (Bir1-A protein) (Survivin/XBIR1) (XBIR1) (Survivin1-a) (XSurvivin1) (XSurvivin1A) (Xsvv1) (xSurvivin) birc5.1-a bir1-A svv1 Xenopus laevis (African clawed frog) TR41958_c1_g9_i10 A9JTP3 BIRC7_XENTR 1.00E-22 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP) (Embryonic/Egg IAP) (EIAP/XLX) birc7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41958_c1_g9_i11 Q24306 IAP1_DROME 1.00E-27 GO:0019788; GO:0016055; GO:0048800; GO:0007298; GO:0008407; GO:0004869; GO:0005737; GO:0008354; GO:0097340; GO:1990001; GO:0043066; GO:0046673; GO:0005634; GO:0090263; GO:0031398; GO:0042787; GO:0045035; GO:0007289; GO:0004842; GO:0008270 P25843; Q86PE7; Q9XYF4; Q24475; Q24106 NEDD8 ligase activity; Wnt receptor signaling pathway; antennal morphogenesis; border follicle cell migration; chaeta morphogenesis; cysteine-type endopeptidase inhibitor activity; cytoplasm; germ cell migration; inhibition of cysteine-type endopeptidase activity; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of compound eye retinal cell programmed cell death; nucleus; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; sensory organ precursor cell division; spermatid nucleus differentiation; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; Apoptosis 1 inhibitor (EC 6.3.2.-) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (dIAP1) (Protein thread) th Iap1 CG12284 Drosophila melanogaster (Fruit fly) TR41958_c1_g9_i3 Q90660 BIR_CHICK 3.00E-21 GO:0006915; GO:0005737; GO:0043066; GO:0005634; GO:0008270 apoptotic process; cytoplasm; negative regulation of apoptotic process; nucleus; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Inhibitor of apoptosis protein (IAP) (Inhibitor of T-cell apoptosis protein) ITA IAP1 Gallus gallus (Chicken) TR41958_c1_g9_i5 Q6R7E2 IAP2_OSHVF 1.00E-07 IPR001370; Putative apoptosis inhibitor ORF87 ORF87 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) TR41958_c1_g9_i6 Q24306 IAP1_DROME 4.00E-28 GO:0019788; GO:0016055; GO:0048800; GO:0007298; GO:0008407; GO:0004869; GO:0005737; GO:0008354; GO:0097340; GO:1990001; GO:0043066; GO:0046673; GO:0005634; GO:0090263; GO:0031398; GO:0042787; GO:0045035; GO:0007289; GO:0004842; GO:0008270 P25843; Q86PE7; Q9XYF4; Q24475; Q24106 NEDD8 ligase activity; Wnt receptor signaling pathway; antennal morphogenesis; border follicle cell migration; chaeta morphogenesis; cysteine-type endopeptidase inhibitor activity; cytoplasm; germ cell migration; inhibition of cysteine-type endopeptidase activity; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of compound eye retinal cell programmed cell death; nucleus; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; sensory organ precursor cell division; spermatid nucleus differentiation; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; Apoptosis 1 inhibitor (EC 6.3.2.-) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (dIAP1) (Protein thread) th Iap1 CG12284 Drosophila melanogaster (Fruit fly) TR41958_c1_g9_i9 A9ULZ2 BIR7B_XENLA 7.00E-27 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) TR41959_c1_g1_i1 P49660 SSR4_MOUSE 3.00E-20 GO:0016021; GO:0005886; GO:0004994; GO:0038170 Q62108 integral to membrane; plasma membrane; somatostatin receptor activity; somatostatin signaling pathway IPR000276; IPR017452; IPR000586; IPR001512; Somatostatin receptor type 4 (SS-4-R) (SS4-R) (SS4R) Sstr4 Smstr4 Mus musculus (Mouse) TR41959_c1_g1_i2 P58308 OX2R_MOUSE 3.00E-28 GO:0022410; GO:0007631; GO:0016021; GO:0007218; GO:0016499; GO:0017046; GO:0007200; GO:0005886 circadian sleep/wake cycle process; feeding behavior; integral to membrane; neuropeptide signaling pathway; orexin receptor activity; peptide hormone binding; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane IPR000276; IPR017452; IPR000204; IPR004060; Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Mox2r Mus musculus (Mouse) TR41959_c1_g1_i3 Q92847 GHSR_HUMAN 7.00E-14 GO:0008154; GO:0008343; GO:0009986; GO:0032869; GO:0046697; GO:0001616; GO:0030252; GO:0016520; GO:0009755; GO:0016021; GO:0045121; GO:0050728; GO:0046676; GO:0032691; GO:0045409; GO:0042536; GO:0043005; GO:0017046; GO:0005886; GO:0032100; GO:0045923; GO:0043568; GO:0040018; GO:0043134; GO:0051963; GO:0032094 actin polymerization or depolymerization; adult feeding behavior; cell surface; cellular response to insulin stimulus; decidualization; growth hormone secretagogue receptor activity; growth hormone secretion; growth hormone-releasing hormone receptor activity; hormone-mediated signaling pathway; integral to membrane; membrane raft; negative regulation of inflammatory response; negative regulation of insulin secretion; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 biosynthetic process; negative regulation of tumor necrosis factor biosynthetic process; neuron projection; peptide hormone binding; plasma membrane; positive regulation of appetite; positive regulation of fatty acid metabolic process; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; regulation of hindgut contraction; regulation of synapse assembly; response to food IPR003905; IPR000276; IPR017452; Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) GHSR Homo sapiens (Human) TR41959_c1_g1_i4 P56719 OX2R_RAT 1.00E-28 GO:0022410; GO:0007631; GO:0016021; GO:0007218; GO:0016499; GO:0017046; GO:0007200; GO:0005886 circadian sleep/wake cycle process; feeding behavior; integral to membrane; neuropeptide signaling pathway; orexin receptor activity; peptide hormone binding; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane IPR000276; IPR017452; IPR000204; IPR004060; Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Rattus norvegicus (Rat) TR41959_c1_g1_i5 P56719 OX2R_RAT 2.00E-28 GO:0022410; GO:0007631; GO:0016021; GO:0007218; GO:0016499; GO:0017046; GO:0007200; GO:0005886 circadian sleep/wake cycle process; feeding behavior; integral to membrane; neuropeptide signaling pathway; orexin receptor activity; peptide hormone binding; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane IPR000276; IPR017452; IPR000204; IPR004060; Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Rattus norvegicus (Rat) TR41959_c1_g1_i6 Q8TCW9 PKR1_HUMAN 6.00E-13 GO:0016021; GO:0043066; GO:0004983; GO:0005886 integral to membrane; negative regulation of apoptotic process; neuropeptide Y receptor activity; plasma membrane IPR000276; IPR017452; IPR000611; Prokineticin receptor 1 (PK-R1) (G-protein coupled receptor 73) (G-protein coupled receptor ZAQ) (GPR73a) PROKR1 GPR73 PKR1 Homo sapiens (Human) TR41960_c0_g1_i2 Q6GQ82 SNF5_XENLA 4.00E-117 GO:0006338; GO:0007399; GO:0000228; GO:0006355; GO:0006351 "chromatin remodeling; nervous system development; nuclear chromosome; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006939; IPR017393; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 smarcb1 Xenopus laevis (African clawed frog) TR41960_c0_g1_i3 Q9USM3 SFH1_SCHPO 5.00E-11 GO:0043044; GO:0016586; GO:0005829; GO:0000790; GO:0006357; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "ATP-dependent chromatin remodeling; RSC complex; cytosol; nuclear chromatin; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR006939; IPR000679; IPR013088; Chromatin structure-remodeling complex subunit sfh1 (RSC complex subunit sfh1) (SNF5 homolog 1) sfh1 SPCC16A11.14 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41960_c0_g3_i1 Q09699 SNF5_SCHPO 3.00E-17 GO:0005794; GO:0016514; GO:0006338; GO:0000991; GO:0010972; GO:0000122; GO:0000790; GO:0010811; GO:0045944; GO:1900389; GO:1900400 Golgi apparatus; SWI/SNF complex; chromatin remodeling; core RNA polymerase II binding transcription factor activity; negative regulation of G2/M transition of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; positive regulation of cell-substrate adhesion; positive regulation of transcription from RNA polymerase II promoter; regulation of glucose import by regulation of transcription from RNA polymerase II promoter; regulation of iron ion import by regulation of transcription from RNA polymerase II promoter IPR006939; SWI/SNF chromatin-remodeling complex subunit snf5 (SWI/SNF complex subunit snf5) snf5 SPAC2F7.08c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41960_c0_g3_i2 P18480 SNF5_YEAST 3.00E-16 GO:0001102; GO:0016514; GO:0000436; GO:0006338; GO:0005829; GO:0000724; GO:0000228; GO:0005987; GO:0006351 P35189 "RNA polymerase II activating transcription factor binding; SWI/SNF complex; carbon catabolite activation of transcription from RNA polymerase II promoter; chromatin remodeling; cytosol; double-strand break repair via homologous recombination; nuclear chromosome; sucrose catabolic process; transcription, DNA-dependent" IPR006939; SWI/SNF chromatin-remodeling complex subunit SNF5 (SWI/SNF complex subunit SNF5) (Transcription factor TYE4) (Transcription regulatory protein SNF5) SNF5 SWI10 TYE4 YBR289W YBR2036 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41960_c0_g3_i4 Q5U379 SNF5_DANRE 5.00E-65 GO:0043044; GO:0090544; GO:0006281; GO:0030154; GO:0044772; GO:0008285; GO:0000228; GO:0006337; GO:0006357; GO:0006351 "ATP-dependent chromatin remodeling; BAF-type complex; DNA repair; cell differentiation; mitotic cell cycle phase transition; negative regulation of cell proliferation; nuclear chromosome; nucleosome disassembly; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR006939; IPR017393; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1-A smarcb1a smarcb1 zgc:92517 Danio rerio (Zebrafish) (Brachydanio rerio) TR41961_c0_g1_i1 O95980 RECK_HUMAN 0 GO:0031225; GO:0001955; GO:0007566; GO:0030198; GO:0016020; GO:0008191; GO:0005886; GO:0004867 P04626 anchored to membrane; blood vessel maturation; embryo implantation; extracellular matrix organization; membrane; metalloendopeptidase inhibitor activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR002350; Reversion-inducing cysteine-rich protein with Kazal motifs (hRECK) (Suppressor of tumorigenicity 15 protein) RECK ST15 Homo sapiens (Human) TR41963_c2_g1_i1 A8E5V9 TM173_XENTR 8.00E-18 GO:0002218; GO:0006915; GO:0061507; GO:0035438; GO:0051607; GO:0005789; GO:0045087; GO:0016021; GO:0032608; GO:0005741; GO:0048471; GO:0005886; GO:0042803 activation of innate immune response; apoptotic process; cyclic-GMP-AMP binding; cyclic-di-GMP binding; defense response to virus; endoplasmic reticulum membrane; innate immune response; integral to membrane; interferon-beta production; mitochondrial outer membrane; perinuclear region of cytoplasm; plasma membrane; protein homodimerization activity Stimulator of interferon genes protein (STING) (Transmembrane protein 173) tmem173 sting Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR41964_c1_g1_i10 Q5ZLG9 WDR59_CHICK 2.00E-41 IPR006575; IPR016135; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 59 WDR59 RCJMB04_6d21 Gallus gallus (Chicken) TR41964_c1_g1_i3 Q5ZLG9 WDR59_CHICK 0 IPR006575; IPR016135; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 59 WDR59 RCJMB04_6d21 Gallus gallus (Chicken) TR41964_c1_g1_i4 Q5ZMV9 WDR24_CHICK 4.00E-12 IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 24 WDR24 RCJMB04_1a19 Gallus gallus (Chicken) TR41964_c1_g1_i9 Q6PJI9 WDR59_HUMAN 0 IPR006575; IPR016135; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 59 WDR59 KIAA1923 FP977 Homo sapiens (Human) TR41966_c1_g1_i2 P42674 BP10_PARLI 1.00E-36 GO:0005938; GO:0005615; GO:0004222; GO:0048471; GO:0006508; GO:0008270 cell cortex; extracellular space; metalloendopeptidase activity; perinuclear region of cytoplasm; proteolysis; zinc ion binding IPR000859; IPR000742; IPR013032; IPR024079; IPR001506; IPR006026; IPR017369; Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) TR41967_c0_g1_i2 P32748 PYRD_DROME 2.00E-66 GO:0044205; GO:0006207; GO:0004152; GO:0004158; GO:0016021; GO:0005743; GO:0005758 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; dihydroorotate dehydrogenase activity; dihydroorotate oxidase activity; integral to membrane; mitochondrial inner membrane; mitochondrial intermembrane space IPR013785; IPR012135; IPR005719; IPR001295; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. "Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (Dihydroorotate oxidase) (EC 1.3.5.2)" Dhod CG9741 Drosophila melanogaster (Fruit fly) TR41967_c0_g2_i1 Q02127 PYRD_HUMAN 2.00E-73 GO:0044205; GO:0006207; GO:0010181; GO:0004152; GO:0004158; GO:0008144; GO:0007565; GO:0016021; GO:0007595; GO:0005743; GO:0043025; GO:0043065; GO:0046134; GO:0090140; GO:0031000; GO:0042493; GO:0042594; GO:0048039 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; FMN binding; dihydroorotate dehydrogenase activity; dihydroorotate oxidase activity; drug binding; female pregnancy; integral to membrane; lactation; mitochondrial inner membrane; neuronal cell body; positive regulation of apoptotic process; pyrimidine nucleoside biosynthetic process; regulation of mitochondrial fission; response to caffeine; response to drug; response to starvation; ubiquinone binding IPR013785; IPR012135; IPR005719; IPR001295; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. "Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase)" DHODH Homo sapiens (Human) TR41967_c0_g2_i10 Q02127 PYRD_HUMAN 1.00E-71 GO:0044205; GO:0006207; GO:0010181; GO:0004152; GO:0004158; GO:0008144; GO:0007565; GO:0016021; GO:0007595; GO:0005743; GO:0043025; GO:0043065; GO:0046134; GO:0090140; GO:0031000; GO:0042493; GO:0042594; GO:0048039 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; FMN binding; dihydroorotate dehydrogenase activity; dihydroorotate oxidase activity; drug binding; female pregnancy; integral to membrane; lactation; mitochondrial inner membrane; neuronal cell body; positive regulation of apoptotic process; pyrimidine nucleoside biosynthetic process; regulation of mitochondrial fission; response to caffeine; response to drug; response to starvation; ubiquinone binding IPR013785; IPR012135; IPR005719; IPR001295; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. "Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase)" DHODH Homo sapiens (Human) TR41967_c0_g2_i2 Q1J132 PYRD_DEIGD 3.00E-47 GO:0044205; GO:0006207; GO:0004158; GO:0005886 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; dihydroorotate oxidase activity; plasma membrane IPR013785; IPR012135; IPR005719; IPR001295; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. Dihydroorotate dehydrogenase (quinone) (EC 1.3.5.2) (DHOdehase) (DHOD) (DHODase) (Dihydroorotate oxidase) pyrD Dgeo_0500 Deinococcus geothermalis (strain DSM 11300) TR41967_c0_g2_i4 A0JX31 PYRD_ARTS2 2.00E-34 GO:0044205; GO:0006207; GO:0004158; GO:0005886 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; dihydroorotate oxidase activity; plasma membrane IPR013785; IPR012135; IPR005719; IPR001295; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. Dihydroorotate dehydrogenase (quinone) (EC 1.3.5.2) (DHOdehase) (DHOD) (DHODase) (Dihydroorotate oxidase) pyrD Arth_2221 Arthrobacter sp. (strain FB24) TR41967_c0_g2_i5 Q6CTX8 PYRD2_KLULA 3.00E-41 GO:0044205; GO:0006207; GO:0004158; GO:0016021; GO:0005743 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; dihydroorotate oxidase activity; integral to membrane; mitochondrial inner membrane IPR013785; IPR012135; IPR005719; IPR001295; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. "Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOD) (DHODase) (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase)" URA9 KLLA0C09240g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR41967_c0_g2_i7 Q99Z28 PYRDA_STRP1 6.00E-10 GO:0044205; GO:0006207; GO:0005737; GO:0052888; GO:0004158 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; cytoplasm; dihydroorotate oxidase (fumarate) activity; dihydroorotate oxidase activity IPR013785; IPR005720; IPR024920; IPR012135; IPR001295; Pyrimidine metabolism; UMP biosynthesis via de novo pathway. Putative dihydroorotate dehydrogenase A (fumarate) (DHOD A) (DHODase A) (DHOdehase A) (EC 1.3.98.1) pyrD SPy_1432 M5005_Spy1165 Streptococcus pyogenes serotype M1 TR41967_c0_g2_i8 P28294 PYRD_AGRAE 3.00E-32 GO:0044205; GO:0006207; GO:0004158; GO:0016021; GO:0005743 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; dihydroorotate oxidase activity; integral to membrane; mitochondrial inner membrane IPR013785; IPR012135; IPR005719; IPR001295; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. "Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOD) (DHODase) (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase)" URA1 Agrocybe aegerita (Black poplar mushroom) (Agaricus aegerita) TR41967_c0_g2_i9 Q2RX27 PYRD_RHORT 2.00E-57 GO:0044205; GO:0006207; GO:0004158; GO:0005886 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; dihydroorotate oxidase activity; plasma membrane IPR013785; IPR012135; IPR005719; IPR001295; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. Dihydroorotate dehydrogenase (quinone) (EC 1.3.5.2) (DHOdehase) (DHOD) (DHODase) (Dihydroorotate oxidase) pyrD Rru_A0514 Rhodospirillum rubrum (strain ATCC 11170 / NCIB 8255) TR41968_c1_g1_i1 F1S584 CTL2_PIG 4.00E-29 GO:0016021; GO:0043123; GO:0004871; GO:0006810 integral to membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity; transport IPR007603; Choline transporter-like protein 2 (Solute carrier family 44 member 2) SLC44A2 CTL2 Sus scrofa (Pig) TR41968_c1_g2_i3 Q6GN42 CTL4_XENLA 4.00E-67 GO:0016021 integral to membrane IPR007603; Choline transporter-like protein 4 (Solute carrier family 44 member 4) slc44a4 ctl4 Xenopus laevis (African clawed frog) TR41968_c1_g2_i4 Q53GD3 CTL4_HUMAN 1.00E-121 GO:0016021; GO:0006656; GO:0005886; GO:0055085 integral to membrane; phosphatidylcholine biosynthetic process; plasma membrane; transmembrane transport IPR007603; Choline transporter-like protein 4 (Solute carrier family 44 member 4) SLC44A4 C6orf29 CTL4 NG22 UNQ441/PRO874 Homo sapiens (Human) TR41968_c1_g2_i5 Q6IP59 CTL2_XENLA 1.00E-143 GO:0016021; GO:0006810 integral to membrane; transport IPR007603; Choline transporter-like protein 2 (Solute carrier family 44 member 2) slc44a2 ctl2 Xenopus laevis (African clawed frog) TR41970_c3_g1_i1 Q8IVE3 PKHH2_HUMAN 6.00E-07 GO:0003779; GO:0030864; GO:0030027; GO:0030835; GO:0005543; GO:0005886 actin binding; cortical actin cytoskeleton; lamellipodium; negative regulation of actin filament depolymerization; phospholipid binding; plasma membrane IPR019749; IPR014352; IPR019748; IPR000299; IPR000857; IPR011993; IPR001849; Pleckstrin homology domain-containing family H member 2 PLEKHH2 KIAA2028 Homo sapiens (Human) TR41971_c0_g2_i1 Q9Z191 EYA4_MOUSE 6.00E-123 GO:0006281; GO:0016568; GO:0005737; GO:0046872; GO:0042474; GO:0005634; GO:0035335; GO:0004725; GO:0006355; GO:0007605; GO:0006351 "DNA repair; chromatin modification; cytoplasm; metal ion binding; middle ear morphogenesis; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; regulation of transcription, DNA-dependent; sensory perception of sound; transcription, DNA-dependent" IPR006545; Eyes absent homolog 4 (EC 3.1.3.48) Eya4 Mus musculus (Mouse) TR41971_c0_g2_i2 Q9Z191 EYA4_MOUSE 6.00E-123 GO:0006281; GO:0016568; GO:0005737; GO:0046872; GO:0042474; GO:0005634; GO:0035335; GO:0004725; GO:0006355; GO:0007605; GO:0006351 "DNA repair; chromatin modification; cytoplasm; metal ion binding; middle ear morphogenesis; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; regulation of transcription, DNA-dependent; sensory perception of sound; transcription, DNA-dependent" IPR006545; Eyes absent homolog 4 (EC 3.1.3.48) Eya4 Mus musculus (Mouse) TR41973_c0_g2_i1 Q9Y345 SC6A5_HUMAN 2.00E-174 GO:0015375; GO:0016021; GO:0005328; GO:0005886; GO:0007268 glycine:sodium symporter activity; integral to membrane; neurotransmitter:sodium symporter activity; plasma membrane; synaptic transmission IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) TR41973_c0_g2_i4 Q96N87 S6A18_HUMAN 1.00E-55 GO:0006865; GO:0005887; GO:0005328; GO:0005886; GO:0055085 amino acid transport; integral to plasma membrane; neurotransmitter:sodium symporter activity; plasma membrane; transmembrane transport IPR000175; IPR002438; Sodium-dependent neutral amino acid transporter B(0)AT3 (Sodium- and chloride-dependent transporter XTRP2) (Solute carrier family 6 member 18) (System B(0) neutral amino acid transporter AT3) SLC6A18 XTRP2 Homo sapiens (Human) TR41974_c2_g1_i1 Q9H9J2 RM44_HUMAN 4.00E-67 GO:0003723; GO:0006396; GO:0005739; GO:0090305; GO:0004525; GO:0005840 RNA binding; RNA processing; mitochondrion; nucleic acid phosphodiester bond hydrolysis; ribonuclease III activity; ribosome IPR014720; IPR000999; "39S ribosomal protein L44, mitochondrial (L44mt) (MRP-L44) (EC 3.1.26.-)" MRPL44 Homo sapiens (Human) TR41975_c2_g3_i2 Q6NY74 RFA1_DANRE 0 GO:0003677; GO:0006260; GO:0007507; GO:0046872; GO:0005634 DNA binding; DNA replication; heart development; metal ion binding; nucleus IPR012340; IPR004365; IPR013955; IPR007199; IPR004591; Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) rpa1 wu:fi14b08 Danio rerio (Zebrafish) (Brachydanio rerio) TR41975_c2_g3_i3 Q6NY74 RFA1_DANRE 0 GO:0003677; GO:0006260; GO:0007507; GO:0046872; GO:0005634 DNA binding; DNA replication; heart development; metal ion binding; nucleus IPR012340; IPR004365; IPR013955; IPR007199; IPR004591; Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) rpa1 wu:fi14b08 Danio rerio (Zebrafish) (Brachydanio rerio) TR41978_c1_g3_i1 Q9CQC9 SAR1B_MOUSE 5.00E-104 GO:0005525; GO:0032580; GO:0005789; GO:0006886; GO:0046872; GO:0016192 GTP binding; Golgi cisterna membrane; endoplasmic reticulum membrane; intracellular protein transport; metal ion binding; vesicle-mediated transport IPR027417; IPR005225; IPR006689; IPR006687; GTP-binding protein SAR1b Sar1b Sara1b Sara2 Mus musculus (Mouse) TR41979_c0_g1_i1 Q96LD4 TRI47_HUMAN 8.00E-06 GO:0005737; GO:0005634; GO:0008270 cytoplasm; nucleus; zinc ion binding IPR001870; IPR008985; IPR006574; IPR003877; IPR000315; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100) TRIM47 GOA RNF100 Homo sapiens (Human) TR41979_c8_g1_i1 P00921 CAH2_BOVIN 2.00E-09 GO:0038166; GO:0004089; GO:0005737; GO:0006730; GO:0005886; GO:2001150; GO:0044070; GO:0051453; GO:0008270 angiotensin-mediated signaling pathway; carbonate dehydratase activity; cytoplasm; one-carbon metabolic process; plasma membrane; positive regulation of dipeptide transmembrane transport; regulation of anion transport; regulation of intracellular pH; zinc ion binding IPR018443; IPR001148; IPR023561; IPR018338; Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II) CA2 Bos taurus (Bovine) TR41980_c1_g1_i1 Q6DFA8 GLD2B_XENLA 3.00E-13 GO:0005524; GO:0030154; GO:0005737; GO:0006397; GO:0046872; GO:0007275; GO:0048477; GO:0004652 ATP binding; cell differentiation; cytoplasm; mRNA processing; metal ion binding; multicellular organismal development; oogenesis; polynucleotide adenylyltransferase activity IPR002934; IPR002058; Poly(A) RNA polymerase GLD2-B (xGLD-2) (EC 2.7.7.19) (PAP-associated domain-containing protein 4-B) papd4-b gld2-b Xenopus laevis (African clawed frog) TR41980_c1_g1_i4 Q4KMD7 STPAP_DANRE 7.00E-51 GO:0005524; GO:0050265; GO:0003730; GO:0006379; GO:0006378; GO:0046872; GO:0016607; GO:0005730; GO:0004652; GO:0016180 ATP binding; RNA uridylyltransferase activity; mRNA 3'-UTR binding; mRNA cleavage; mRNA polyadenylation; metal ion binding; nuclear speck; nucleolus; polynucleotide adenylyltransferase activity; snRNA processing IPR012677; IPR002058; IPR000504; IPR007087; IPR015880; Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) tut1 rbm21 zgc:112254 Danio rerio (Zebrafish) (Brachydanio rerio) TR41980_c1_g1_i5 Q9NVV4 PAPD1_HUMAN 3.00E-43 GO:0005524; GO:0005794; GO:0003723; GO:0002134; GO:0008219; GO:0071044; GO:0006378; GO:0000287; GO:0030145; GO:0005739; GO:0005634; GO:0005886; GO:0004652; GO:0006351 Itself; Q9QYP6; Q13137; Q9UHD2 "ATP binding; Golgi apparatus; RNA binding; UTP binding; cell death; histone mRNA catabolic process; mRNA polyadenylation; magnesium ion binding; manganese ion binding; mitochondrion; nucleus; plasma membrane; polynucleotide adenylyltransferase activity; transcription, DNA-dependent" IPR002058; "Poly(A) RNA polymerase, mitochondrial (PAP) (EC 2.7.7.19) (PAP-associated domain-containing protein 1) (Polynucleotide adenylyltransferase) (Terminal uridylyltransferase 1) (TUTase 1) (mtPAP)" MTPAP PAPD1 Homo sapiens (Human) TR41980_c1_g1_i6 Q4KMD7 STPAP_DANRE 2.00E-51 GO:0005524; GO:0050265; GO:0003730; GO:0006379; GO:0006378; GO:0046872; GO:0016607; GO:0005730; GO:0004652; GO:0016180 ATP binding; RNA uridylyltransferase activity; mRNA 3'-UTR binding; mRNA cleavage; mRNA polyadenylation; metal ion binding; nuclear speck; nucleolus; polynucleotide adenylyltransferase activity; snRNA processing IPR012677; IPR002058; IPR000504; IPR007087; IPR015880; Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) tut1 rbm21 zgc:112254 Danio rerio (Zebrafish) (Brachydanio rerio) TR41980_c1_g1_i8 Q5BLK4 TUT7_MOUSE 4.00E-26 GO:0031123; GO:0050265; GO:0003676; GO:0008270 RNA 3'-end processing; RNA uridylyltransferase activity; nucleic acid binding; zinc ion binding IPR002058; IPR015880; IPR001878; Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6) Zcchc6 Kiaa1711 Tut7 Mus musculus (Mouse) TR41980_c1_g1_i9 Q4KMD7 STPAP_DANRE 2.00E-51 GO:0005524; GO:0050265; GO:0003730; GO:0006379; GO:0006378; GO:0046872; GO:0016607; GO:0005730; GO:0004652; GO:0016180 ATP binding; RNA uridylyltransferase activity; mRNA 3'-UTR binding; mRNA cleavage; mRNA polyadenylation; metal ion binding; nuclear speck; nucleolus; polynucleotide adenylyltransferase activity; snRNA processing IPR012677; IPR002058; IPR000504; IPR007087; IPR015880; Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) tut1 rbm21 zgc:112254 Danio rerio (Zebrafish) (Brachydanio rerio) TR41981_c1_g1_i1 Q96FL8 S47A1_HUMAN 2.00E-11 GO:0015238; GO:0016021; GO:0031988; GO:0005451; GO:0015695; GO:0005886; GO:0055085 drug transmembrane transporter activity; integral to membrane; membrane-bounded vesicle; monovalent cation:hydrogen antiporter activity; organic cation transport; plasma membrane; transmembrane transport IPR002528; Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1) SLC47A1 MATE1 Homo sapiens (Human) TR41981_c1_g5_i4 Q3V050 S47A2_MOUSE 4.00E-86 GO:0015297; GO:0015238; GO:0016021 antiporter activity; drug transmembrane transporter activity; integral to membrane IPR002528; Multidrug and toxin extrusion protein 2 (MATE-2) (mMATE-2) (H(+)/organic cation antiporter kidney-specific) (Solute carrier family 47 member 2) Slc47a2 Mate2 Mus musculus (Mouse) TR41981_c1_g5_i5 Q5MZD9 NORM_SYNP6 2.00E-12 GO:0015297; GO:0015238; GO:0016021; GO:0006811; GO:0005886 antiporter activity; drug transmembrane transporter activity; integral to membrane; ion transport; plasma membrane IPR002528; Probable multidrug resistance protein NorM (Multidrug-efflux transporter) norM syc2391_d Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans) TR41982_c0_g1_i1 Q9QZH2 BARD1_RAT 5.00E-12 GO:0031436; GO:0006281; GO:0005737; GO:0016874; GO:0043066; GO:0046826; GO:0043065; GO:0085020; GO:0042803; GO:0042325; GO:0007283; GO:0008270 BRCA1-BARD1 complex; DNA repair; cytoplasm; ligase activity; negative regulation of apoptotic process; negative regulation of protein export from nucleus; positive regulation of apoptotic process; protein K6-linked ubiquitination; protein homodimerization activity; regulation of phosphorylation; spermatogenesis; zinc ion binding IPR002110; IPR020683; IPR001357; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. BRCA1-associated RING domain protein 1 (BARD-1) (EC 6.3.2.-) Bard1 Rattus norvegicus (Rat) TR41982_c0_g1_i2 Q9ERK0 RIPK4_MOUSE 1.00E-27 GO:0005524; GO:0005737; GO:0016020; GO:0004674 Q6Q0C0 ATP binding; cytoplasm; membrane; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR017441; IPR008271; Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-associated protein kinase) (PKC-regulated protein kinase) Ripk4 Ankrd3 Pkk Mus musculus (Mouse) TR41983_c0_g4_i3 Q5ZMM5 ZN706_CHICK 2.00E-14 GO:0046872 metal ion binding IPR007513; IPR026939; IPR015880; Zinc finger protein 706 ZNF706 RCJMB04_1j21 Gallus gallus (Chicken) TR41984_c2_g2_i4 A6H737 LOXL2_BOVIN 3.00E-07 GO:0005604; GO:0003682; GO:0005694; GO:0030199; GO:0005507; GO:0043542; GO:0001935; GO:0001837; GO:0005615; GO:0016570; GO:0016020; GO:0035064; GO:0045892; GO:0005634; GO:0070492; GO:0032332; GO:0018277; GO:0004720; GO:0046688; GO:0001666; GO:0005044; GO:0002040; GO:0003714; GO:0006351 "basement membrane; chromatin binding; chromosome; collagen fibril organization; copper ion binding; endothelial cell migration; endothelial cell proliferation; epithelial to mesenchymal transition; extracellular space; histone modification; membrane; methylated histone residue binding; negative regulation of transcription, DNA-dependent; nucleus; oligosaccharide binding; positive regulation of chondrocyte differentiation; protein deamination; protein-lysine 6-oxidase activity; response to copper ion; response to hypoxia; scavenger receptor activity; sprouting angiogenesis; transcription corepressor activity; transcription, DNA-dependent" IPR001695; IPR019828; IPR001190; IPR017448; Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) LOXL2 Bos taurus (Bovine) TR41984_c2_g2_i9 Q9Y4K0 LOXL2_HUMAN 6.00E-06 GO:0007568; GO:0005604; GO:0007155; GO:0003682; GO:0005694; GO:0030199; GO:0005507; GO:0009055; GO:0043542; GO:0001935; GO:0001837; GO:0005615; GO:0016570; GO:0016020; GO:0035064; GO:0045892; GO:0005634; GO:0070492; GO:0032332; GO:0018277; GO:0004720; GO:0046688; GO:0001666; GO:0005044; GO:0002040; GO:0003714; GO:0006351 "aging; basement membrane; cell adhesion; chromatin binding; chromosome; collagen fibril organization; copper ion binding; electron carrier activity; endothelial cell migration; endothelial cell proliferation; epithelial to mesenchymal transition; extracellular space; histone modification; membrane; methylated histone residue binding; negative regulation of transcription, DNA-dependent; nucleus; oligosaccharide binding; positive regulation of chondrocyte differentiation; protein deamination; protein-lysine 6-oxidase activity; response to copper ion; response to hypoxia; scavenger receptor activity; sprouting angiogenesis; transcription corepressor activity; transcription, DNA-dependent" IPR001695; IPR019828; IPR001190; IPR017448; Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14) LOXL2 Homo sapiens (Human) TR41985_c6_g2_i4 Q9Y6R7 FCGBP_HUMAN 8.00E-14 GO:0005737; GO:0005576 cytoplasm; extracellular region IPR003645; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) TR41985_c9_g1_i1 Q9Y6R7 FCGBP_HUMAN 1.00E-07 GO:0005737; GO:0005576 cytoplasm; extracellular region IPR003645; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) TR41987_c0_g3_i2 Q9PW28 IF4EB_DANRE 3.00E-15 GO:0016281; GO:0005845; GO:0005634; GO:0006417; GO:0003743 eukaryotic translation initiation factor 4F complex; mRNA cap binding complex; nucleus; regulation of translation; translation initiation factor activity IPR023398; IPR001040; IPR019770; Eukaryotic translation initiation factor 4E-1B (eIF4E) (eIF4E-1B) eif4e1b Danio rerio (Zebrafish) (Brachydanio rerio) TR41987_c0_g3_i3 Q8N5X7 IF4E3_HUMAN 8.00E-66 GO:0019221; GO:0005829; GO:0005845; GO:0006417; GO:0003743 cytokine-mediated signaling pathway; cytosol; mRNA cap binding complex; regulation of translation; translation initiation factor activity IPR023398; IPR001040; Eukaryotic translation initiation factor 4E type 3 (eIF-4E type 3) (eIF-4E3) (eIF4E type 3) (eIF4E-3) EIF4E3 Homo sapiens (Human) TR41987_c0_g3_i4 Q9DBB5 IF4E3_MOUSE 4.00E-62 GO:0005737; GO:0005845; GO:0006417; GO:0003743 cytoplasm; mRNA cap binding complex; regulation of translation; translation initiation factor activity IPR023398; IPR001040; Eukaryotic translation initiation factor 4E type 3 (eIF-4E type 3) (eIF-4E3) (eIF4E type 3) (eIF4E-3) Eif4e3 Mus musculus (Mouse) TR41989_c3_g1_i10 P27658 CO8A1_HUMAN 5.00E-09 GO:0001525; GO:0005604; GO:0048593; GO:0007155; GO:0030574; GO:0005591; GO:0005788; GO:0050673; GO:0022617; GO:0010811 angiogenesis; basement membrane; camera-type eye morphogenesis; cell adhesion; collagen catabolic process; collagen type VIII; endoplasmic reticulum lumen; epithelial cell proliferation; extracellular matrix disassembly; positive regulation of cell-substrate adhesion IPR001073; IPR008160; IPR008983; Collagen alpha-1(VIII) chain (Endothelial collagen) [Cleaved into: Vastatin] COL8A1 C3orf7 Homo sapiens (Human) TR41989_c3_g1_i2 P25067 CO8A2_HUMAN 2.00E-06 GO:0001525; GO:0005604; GO:0048593; GO:0016337; GO:0005581; GO:0030574; GO:0005788; GO:0050673; GO:0022617; GO:0005201; GO:0030674 "angiogenesis; basement membrane; camera-type eye morphogenesis; cell-cell adhesion; collagen; collagen catabolic process; endoplasmic reticulum lumen; epithelial cell proliferation; extracellular matrix disassembly; extracellular matrix structural constituent; protein binding, bridging" IPR001073; IPR008160; IPR008983; Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) TR41989_c3_g1_i7 Q9ESN4 C1QL3_MOUSE 8.00E-10 GO:0005581; GO:0005576; GO:0050807 collagen; extracellular region; regulation of synapse organization IPR001073; IPR008160; IPR008983; Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13) (CTRP13) (Gliacolin) C1ql3 C1ql Ctrp13 Mus musculus (Mouse) TR41991_c1_g1_i2 Q9CSU0 RPR1B_MOUSE 1.00E-95 GO:0016591; GO:0000993; GO:0070940; GO:0008284; GO:0045944; GO:0010564; GO:0006351 "DNA-directed RNA polymerase II, holoenzyme; RNA polymerase II core binding; dephosphorylation of RNA polymerase II C-terminal domain; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell cycle process; transcription, DNA-dependent" IPR006569; IPR008942; IPR006903; Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) Rprd1b Crept Mus musculus (Mouse) TR41991_c1_g1_i7 Q9CSU0 RPR1B_MOUSE 3.00E-68 GO:0016591; GO:0000993; GO:0070940; GO:0008284; GO:0045944; GO:0010564; GO:0006351 "DNA-directed RNA polymerase II, holoenzyme; RNA polymerase II core binding; dephosphorylation of RNA polymerase II C-terminal domain; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell cycle process; transcription, DNA-dependent" IPR006569; IPR008942; IPR006903; Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) Rprd1b Crept Mus musculus (Mouse) TR41992_c1_g1_i1 Q9HCX4 TRPC7_HUMAN 3.00E-06 GO:0007411; GO:0005262; GO:0016021; GO:0006828; GO:0005635; GO:0005886; GO:0030168 axon guidance; calcium channel activity; integral to membrane; manganese ion transport; nuclear envelope; plasma membrane; platelet activation IPR002110; IPR020683; IPR005821; IPR004729; IPR013555; IPR005463; IPR002153; Short transient receptor potential channel 7 (TrpC7) (Transient receptor protein 7) (TRP-7) (hTRP7) TRPC7 TRP7 Homo sapiens (Human) TR41992_c2_g1_i2 Q9WUU8 TNIP1_MOUSE 3.00E-16 GO:0002755; GO:0005737; GO:0006954; GO:0007159; GO:0051019; GO:0070373; GO:0043124; GO:0005634; GO:0031593; GO:0050729; GO:0045944 Q60769 MyD88-dependent toll-like receptor signaling pathway; cytoplasm; inflammatory response; leukocyte cell-cell adhesion; mitogen-activated protein kinase binding; negative regulation of ERK1 and ERK2 cascade; negative regulation of I-kappaB kinase/NF-kappaB cascade; nucleus; polyubiquitin binding; positive regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN) (ABIN-1) (Nef-associated factor 1) (Naf1) (Virion-associated nuclear shuttling protein) (VAN) (mVAN) Tnip1 Abin Naf1 Mus musculus (Mouse) TR41992_c2_g1_i4 Q96KP6 TNIP3_HUMAN 5.00E-08 GO:0002756; GO:0071222; GO:0006954; GO:0043124; GO:0031593; GO:0034142 MyD88-independent toll-like receptor signaling pathway; cellular response to lipopolysaccharide; inflammatory response; negative regulation of I-kappaB kinase/NF-kappaB cascade; polyubiquitin binding; toll-like receptor 4 signaling pathway TNFAIP3-interacting protein 3 (A20-binding inhibitor of NF-kappa-B activation 3) (ABIN-3) (Listeria-induced gene protein) TNIP3 ABIN3 LIND Homo sapiens (Human) TR41992_c2_g1_i5 Q9WUU8 TNIP1_MOUSE 3.00E-16 GO:0002755; GO:0005737; GO:0006954; GO:0007159; GO:0051019; GO:0070373; GO:0043124; GO:0005634; GO:0031593; GO:0050729; GO:0045944 Q60769 MyD88-dependent toll-like receptor signaling pathway; cytoplasm; inflammatory response; leukocyte cell-cell adhesion; mitogen-activated protein kinase binding; negative regulation of ERK1 and ERK2 cascade; negative regulation of I-kappaB kinase/NF-kappaB cascade; nucleus; polyubiquitin binding; positive regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN) (ABIN-1) (Nef-associated factor 1) (Naf1) (Virion-associated nuclear shuttling protein) (VAN) (mVAN) Tnip1 Abin Naf1 Mus musculus (Mouse) TR41993_c2_g1_i1 Q91147 FGFR2_NOTVI 2.00E-163 GO:0005524; GO:0005794; GO:0006915; GO:0016023; GO:0048701; GO:0005007; GO:0016021; GO:0018108; GO:0005886; GO:0008284 ATP binding; Golgi apparatus; apoptotic process; cytoplasmic membrane-bounded vesicle; embryonic cranial skeleton morphogenesis; fibroblast growth factor-activated receptor activity; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; positive regulation of cell proliferation IPR028175; IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) FGFR2 Notophthalmus viridescens (Eastern newt) (Triturus viridescens) TR41993_c2_g1_i10 Q9I8X3 FGFR3_DANRE 3.00E-163 GO:0005524; GO:0006915; GO:0005007; GO:0016021; GO:0018108; GO:0005886; GO:0008284; GO:0001501 ATP binding; apoptotic process; fibroblast growth factor-activated receptor activity; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; positive regulation of cell proliferation; skeletal system development IPR028176; IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR020635; Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) fgfr3 Danio rerio (Zebrafish) (Brachydanio rerio) TR41993_c2_g1_i11 Q91285 FGFR1_PLEWA 1.00E-159 GO:0005524; GO:0016023; GO:0005829; GO:0005007; GO:0016021; GO:0060173; GO:0005634; GO:0005886; GO:0008284 ATP binding; cytoplasmic membrane-bounded vesicle; cytosol; fibroblast growth factor-activated receptor activity; integral to membrane; limb development; nucleus; plasma membrane; positive regulation of cell proliferation IPR028174; IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (PFR1) FGFR1 Pleurodeles waltl (Iberian ribbed newt) TR41993_c2_g1_i3 Q92772 CDKL2_HUMAN 4.00E-15 GO:0005524; GO:0005813; GO:0004693; GO:0005737; GO:0005634; GO:0004672; GO:0007548; GO:0007165 ATP binding; centrosome; cyclin-dependent protein serine/threonine kinase activity; cytoplasm; nucleus; protein kinase activity; sex differentiation; signal transduction IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Protein kinase p56 KKIAMRE) (Serine/threonine-protein kinase KKIAMRE) CDKL2 Homo sapiens (Human) TR41993_c2_g1_i4 Q64605 PTPRS_RAT 3.00E-07 GO:0007155; GO:0016021; GO:0004725 cell adhesion; integral to membrane; protein tyrosine phosphatase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Leukocyte common antigen-related protein-tyrosine phosphatase 2) (LAR-PTP2) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma) Ptprs Rattus norvegicus (Rat) TR41993_c2_g1_i5 Q90413 FGFR4_DANRE 8.00E-143 GO:0005524; GO:0005783; GO:0005768; GO:0005007; GO:0016021; GO:0005886; GO:0008284 A4JYD4 ATP binding; endoplasmic reticulum; endosome; fibroblast growth factor-activated receptor activity; integral to membrane; plasma membrane; positive regulation of cell proliferation IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR013151; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) fgfr4 Danio rerio (Zebrafish) (Brachydanio rerio) TR41993_c2_g1_i6 P18460 FGFR3_CHICK 5.00E-166 GO:0005524; GO:0006915; GO:0005007; GO:0016021; GO:0018108; GO:0005886; GO:0008284; GO:0001501 ATP binding; apoptotic process; fibroblast growth factor-activated receptor activity; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; positive regulation of cell proliferation; skeletal system development IPR028176; IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR013151; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (Tyrosine kinase receptor CEK2) FGFR3 CEK2 Gallus gallus (Chicken) TR41993_c2_g1_i7 Q91V87 FGRL1_MOUSE 3.00E-28 GO:0060539; GO:0005007; GO:0003179; GO:0008201; GO:0005887; GO:0008285; GO:0040037; GO:0001571; GO:0001501; GO:0060412 diaphragm development; fibroblast growth factor-activated receptor activity; heart valve morphogenesis; heparin binding; integral to plasma membrane; negative regulation of cell proliferation; negative regulation of fibroblast growth factor receptor signaling pathway; non-tyrosine kinase fibroblast growth factor receptor activity; skeletal system development; ventricular septum morphogenesis IPR007110; IPR013783; IPR013098; IPR003598; Fibroblast growth factor receptor-like 1 (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-5) Fgfrl1 Fgfr5 Mus musculus (Mouse) TR41993_c2_g1_i8 Q91147 FGFR2_NOTVI 2.00E-164 GO:0005524; GO:0005794; GO:0006915; GO:0016023; GO:0048701; GO:0005007; GO:0016021; GO:0018108; GO:0005886; GO:0008284 ATP binding; Golgi apparatus; apoptotic process; cytoplasmic membrane-bounded vesicle; embryonic cranial skeleton morphogenesis; fibroblast growth factor-activated receptor activity; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; positive regulation of cell proliferation IPR028175; IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) FGFR2 Notophthalmus viridescens (Eastern newt) (Triturus viridescens) TR41993_c2_g1_i9 Q498D6 FGFR4_RAT 1.00E-139 GO:0005524; GO:0016477; GO:0005911; GO:0005783; GO:0005768; GO:0017134; GO:0005007; GO:0042593; GO:0008201; GO:0005887; GO:0055062; GO:2000573; GO:0070374; GO:0008284; GO:0048554; GO:0045862; GO:0046777; GO:0070857; GO:2000188; GO:0010715 ATP binding; cell migration; cell-cell junction; endoplasmic reticulum; endosome; fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; glucose homeostasis; heparin binding; integral to plasma membrane; phosphate ion homeostasis; positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of cell proliferation; positive regulation of metalloenzyme activity; positive regulation of proteolysis; protein autophosphorylation; regulation of bile acid biosynthetic process; regulation of cholesterol homeostasis; regulation of extracellular matrix disassembly IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334) Fgfr4 Rattus norvegicus (Rat) TR41994_c1_g2_i2 P12311 ADH1_GEOSE 3.00E-10 GO:0004022; GO:0008270 alcohol dehydrogenase (NAD) activity; zinc ion binding IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; Alcohol dehydrogenase (EC 1.1.1.1) (ADH-T) adhT Geobacillus stearothermophilus (Bacillus stearothermophilus) TR41994_c1_g2_i5 Q4J781 ADH_SULAC 4.00E-13 GO:0004022; GO:0008270 alcohol dehydrogenase (NAD) activity; zinc ion binding IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; NAD-dependent alcohol dehydrogenase (EC 1.1.1.1) adh Saci_2057 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) TR41994_c1_g2_i6 Q4J781 ADH_SULAC 3.00E-13 GO:0004022; GO:0008270 alcohol dehydrogenase (NAD) activity; zinc ion binding IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; NAD-dependent alcohol dehydrogenase (EC 1.1.1.1) adh Saci_2057 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) TR41994_c1_g2_i7 Q5X748 TDH_LEGPA 7.00E-07 GO:0008743; GO:0019518; GO:0005737; GO:0008270 L-threonine 3-dehydrogenase activity; L-threonine catabolic process to glycine; cytoplasm; zinc ion binding IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR004627; IPR016040; Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2. L-threonine 3-dehydrogenase (EC 1.1.1.103) tdh lpp0757 Legionella pneumophila (strain Paris) TR41996_c0_g1_i1 Q8BW94 DYH3_MOUSE 6.00E-20 GO:0005524; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR026983; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 3, axonemal (Axonemal beta dynein heavy chain 3) (Ciliary dynein heavy chain 3)" Dnah3 Dnahc3 Mus musculus (Mouse) TR41996_c1_g3_i1 P14735 IDE_HUMAN 0 GO:0005524; GO:0016887; GO:0001540; GO:0050435; GO:0031626; GO:0010815; GO:0009986; GO:0005829; GO:0031597; GO:0008340; GO:0005615; GO:0042447; GO:0043559; GO:1901143; GO:0008286; GO:0004222; GO:0005739; GO:0019048; GO:0045861; GO:0005634; GO:0005782; GO:0005777; GO:0005886; GO:0032461; GO:0051291; GO:0051260; GO:0051289; GO:0051603; GO:0010992; GO:0008270 P10147 ATP binding; ATPase activity; beta-amyloid binding; beta-amyloid metabolic process; beta-endorphin binding; bradykinin catabolic process; cell surface; cytosol; cytosolic proteasome complex; determination of adult lifespan; extracellular space; hormone catabolic process; insulin binding; insulin catabolic process; insulin receptor signaling pathway; metalloendopeptidase activity; mitochondrion; modulation by virus of host morphology or physiology; negative regulation of proteolysis; nucleus; peroxisomal matrix; peroxisome; plasma membrane; positive regulation of protein oligomerization; protein heterooligomerization; protein homooligomerization; protein homotetramerization; proteolysis involved in cellular protein catabolic process; ubiquitin homeostasis; zinc ion binding IPR011249; IPR011237; IPR011765; IPR001431; IPR007863; Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin) IDE Homo sapiens (Human) TR41996_c1_g4_i2 Q06010 STE23_YEAST 7.00E-28 GO:0019898; GO:0046872; GO:0004222; GO:0007323; GO:0006508; GO:0019236 extrinsic to membrane; metal ion binding; metalloendopeptidase activity; peptide pheromone maturation; proteolysis; response to pheromone IPR011249; IPR011237; IPR011765; IPR001431; IPR007863; A-factor-processing enzyme (EC 3.4.24.-) (Insulin-degrading enzyme homolog) STE23 YLR389C L8084.12 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41996_c1_g4_i3 Q24K02 IDE_BOVIN 3.00E-90 GO:0005524; GO:0050435; GO:0010815; GO:0009986; GO:0005829; GO:0008340; GO:0005615; GO:0043559; GO:1901143; GO:0004222; GO:0005739; GO:0005634; GO:0005777; GO:0005886; GO:0032461; GO:0051260; GO:0051603; GO:0010992; GO:0008270 ATP binding; beta-amyloid metabolic process; bradykinin catabolic process; cell surface; cytosol; determination of adult lifespan; extracellular space; insulin binding; insulin catabolic process; metalloendopeptidase activity; mitochondrion; nucleus; peroxisome; plasma membrane; positive regulation of protein oligomerization; protein homooligomerization; proteolysis involved in cellular protein catabolic process; ubiquitin homeostasis; zinc ion binding IPR011249; IPR011237; IPR011765; IPR001431; IPR007863; Insulin-degrading enzyme (EC 3.4.24.56) (Insulin protease) (Insulinase) (Insulysin) IDE Bos taurus (Bovine) TR41996_c1_g4_i6 O14077 MU138_SCHPO 5.00E-34 GO:0005829; GO:0007126; GO:0046872; GO:0004222; GO:0071432; GO:0006508 cytosol; meiosis; metal ion binding; metalloendopeptidase activity; peptide mating pheromone maturation involved in conjugation with cellular fusion; proteolysis IPR011249; IPR011237; IPR011765; IPR001431; IPR007863; Putative zinc protease mug138 (EC 3.4.24.-) (Meiotically up-regulated gene 138 protein) mug138 SPAC2E11.12c SPACUNK4.12c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41997_c1_g1_i1 Q6PI48 SYDM_HUMAN 0 GO:0005524; GO:0004815; GO:0050560; GO:0070145; GO:0005759; GO:0005634; GO:0000049 ATP binding; aspartate-tRNA ligase activity; aspartate-tRNA(Asn) ligase activity; mitochondrial asparaginyl-tRNA aminoacylation; mitochondrial matrix; nucleus; tRNA binding IPR004364; IPR018150; IPR006195; IPR004524; IPR002312; IPR004115; IPR012340; IPR004365; "Aspartate--tRNA ligase, mitochondrial (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS)" DARS2 Homo sapiens (Human) TR41997_c1_g1_i3 Q89A27 EPMA_BUCBP 2.00E-07 GO:0005524; GO:0016880; GO:0005737; GO:0004824; GO:0006430; GO:0071915 ATP binding; acid-ammonia (or amide) ligase activity; cytoplasm; lysine-tRNA ligase activity; lysyl-tRNA aminoacylation; protein-lysine lysylation IPR004364; IPR018150; IPR006195; IPR004525; Elongation factor P--(R)-beta-lysine ligase (EF-P--(R)-beta-lysine ligase) (EC 6.3.1.-) (EF-P post-translational modification enzyme A) (EF-P-lysine lysyltransferase) epmA yjeA bbp_528 Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) TR41997_c1_g1_i5 Q6PI48 SYDM_HUMAN 0 GO:0005524; GO:0004815; GO:0050560; GO:0070145; GO:0005759; GO:0005634; GO:0000049 ATP binding; aspartate-tRNA ligase activity; aspartate-tRNA(Asn) ligase activity; mitochondrial asparaginyl-tRNA aminoacylation; mitochondrial matrix; nucleus; tRNA binding IPR004364; IPR018150; IPR006195; IPR004524; IPR002312; IPR004115; IPR012340; IPR004365; "Aspartate--tRNA ligase, mitochondrial (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS)" DARS2 Homo sapiens (Human) TR41997_c1_g1_i6 Q43776 SYK_SOLLC 5.00E-12 GO:0005524; GO:0010388; GO:0005829; GO:0004824; GO:0006430; GO:0000085; GO:0003676; GO:0009165; GO:0009640; GO:0009506 ATP binding; cullin deneddylation; cytosol; lysine-tRNA ligase activity; lysyl-tRNA aminoacylation; mitotic G2 phase; nucleic acid binding; nucleotide biosynthetic process; photomorphogenesis; plasmodesma IPR004364; IPR018150; IPR006195; IPR002313; IPR018149; IPR012340; IPR004365; Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) LYSRS Solanum lycopersicum (Tomato) (Lycopersicon esculentum) TR41999_c1_g1_i2 Q6DC64 MET16_DANRE 4.00E-110 GO:0008168 methyltransferase activity IPR010286; IPR017182; Methyltransferase-like protein 16 (EC 2.1.1.-) (Methyltransferase 10 domain-containing protein) mettl16 mett10d zgc:100981 Danio rerio (Zebrafish) (Brachydanio rerio) TR41999_c1_g1_i3 Q7K3B9 MET16_DROME 3.00E-67 GO:0008168; GO:0003676 methyltransferase activity; nucleic acid binding IPR002052; IPR010286; IPR017182; Methyltransferase-like protein 16 homolog (EC 2.1.1.-) (Methyltransferase 10 domain-containing protein) CG7544 Drosophila melanogaster (Fruit fly) TR41999_c1_g1_i4 Q5ZIA0 MET16_CHICK 7.00E-105 GO:0008168 methyltransferase activity IPR010286; IPR017182; Methyltransferase-like protein 16 (EC 2.1.1.-) (Methyltransferase 10 domain-containing protein) METTL16 METT10D RCJMB04_28o5 Gallus gallus (Chicken) TR41999_c1_g1_i6 Q6DC64 MET16_DANRE 5.00E-112 GO:0008168 methyltransferase activity IPR010286; IPR017182; Methyltransferase-like protein 16 (EC 2.1.1.-) (Methyltransferase 10 domain-containing protein) mettl16 mett10d zgc:100981 Danio rerio (Zebrafish) (Brachydanio rerio) TR42000_c1_g4_i10 Q98948 SSBP3_CHICK 1.00E-53 GO:0005634; GO:0006355; GO:0003697; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; single-stranded DNA binding; transcription, DNA-dependent" IPR006594; IPR008116; Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein) SSBP3 SSDP Gallus gallus (Chicken) TR42000_c1_g4_i2 Q98948 SSBP3_CHICK 1.00E-53 GO:0005634; GO:0006355; GO:0003697; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; single-stranded DNA binding; transcription, DNA-dependent" IPR006594; IPR008116; Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein) SSBP3 SSDP Gallus gallus (Chicken) TR42000_c1_g4_i6 Q98948 SSBP3_CHICK 1.00E-53 GO:0005634; GO:0006355; GO:0003697; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; single-stranded DNA binding; transcription, DNA-dependent" IPR006594; IPR008116; Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein) SSBP3 SSDP Gallus gallus (Chicken) TR42001_c0_g1_i1 B5FYQ0 ARL3_TAEGU 3.00E-86 GO:0019003; GO:0005525; GO:0003924; GO:0005794; GO:0000139; GO:0005813; GO:0060271; GO:0000910; GO:0005881; GO:0042073; GO:0001822; GO:0008017; GO:0030496; GO:0005634; GO:0042461; GO:0032391; GO:0005886; GO:0015031; GO:0007264; GO:0005876 GDP binding; GTP binding; GTPase activity; Golgi apparatus; Golgi membrane; centrosome; cilium morphogenesis; cytokinesis; cytoplasmic microtubule; intraflagellar transport; kidney development; microtubule binding; midbody; nucleus; photoreceptor cell development; photoreceptor connecting cilium; plasma membrane; protein transport; small GTPase mediated signal transduction; spindle microtubule IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 3 ARL3 Taeniopygia guttata (Zebra finch) (Poephila guttata) TR42001_c0_g1_i2 Q627K4 ARL2_CAEBR 2.00E-46 GO:0005525; GO:0005813; GO:0000910; GO:0005737; GO:0009790; GO:0030540; GO:0005886; GO:0004871; GO:0007264 GTP binding; centrosome; cytokinesis; cytoplasm; embryo development; female genitalia development; plasma membrane; signal transducer activity; small GTPase mediated signal transduction IPR027417; IPR000014; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 2 (Abnormal eversion of vulva protein 20) evl-20.1 arl-2.1 CBG00634; evl-20.2 arl-2.2 CBG24969 Caenorhabditis briggsae TR42001_c0_g1_i4 P78976 SAR1_HYPJE 1.00E-18 GO:0012507; GO:0005525; GO:0000139; GO:0005789; GO:0016787; GO:0006886; GO:0016192 ER to Golgi transport vesicle membrane; GTP binding; Golgi membrane; endoplasmic reticulum membrane; hydrolase activity; intracellular protein transport; vesicle-mediated transport IPR027417; IPR005225; IPR006689; IPR006687; Small COPII coat GTPase sar1 (EC 3.6.5.-) sar1 Hypocrea jecorina (Trichoderma reesei) TR42001_c0_g1_i5 B5FYQ0 ARL3_TAEGU 6.00E-83 GO:0019003; GO:0005525; GO:0003924; GO:0005794; GO:0000139; GO:0005813; GO:0060271; GO:0000910; GO:0005881; GO:0042073; GO:0001822; GO:0008017; GO:0030496; GO:0005634; GO:0042461; GO:0032391; GO:0005886; GO:0015031; GO:0007264; GO:0005876 GDP binding; GTP binding; GTPase activity; Golgi apparatus; Golgi membrane; centrosome; cilium morphogenesis; cytokinesis; cytoplasmic microtubule; intraflagellar transport; kidney development; microtubule binding; midbody; nucleus; photoreceptor cell development; photoreceptor connecting cilium; plasma membrane; protein transport; small GTPase mediated signal transduction; spindle microtubule IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 3 ARL3 Taeniopygia guttata (Zebra finch) (Poephila guttata) TR42002_c0_g1_i5 O95628 CNOT4_HUMAN 4.00E-130 GO:0003723; GO:0005829; GO:0000289; GO:0000166; GO:0005634; GO:0051865; GO:0004842; GO:0008270 RNA binding; cytosol; nuclear-transcribed mRNA poly(A) tail shortening; nucleotide binding; nucleus; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR012677; IPR000504; IPR000571; IPR001841; IPR013083; Protein modification; protein ubiquitination. CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (CCR4-associated factor 4) (E3 ubiquitin-protein ligase CNOT4) (Potential transcriptional repressor NOT4Hp) CNOT4 NOT4 Homo sapiens (Human) TR42002_c0_g1_i9 O95628 CNOT4_HUMAN 3.00E-130 GO:0003723; GO:0005829; GO:0000289; GO:0000166; GO:0005634; GO:0051865; GO:0004842; GO:0008270 RNA binding; cytosol; nuclear-transcribed mRNA poly(A) tail shortening; nucleotide binding; nucleus; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR012677; IPR000504; IPR000571; IPR001841; IPR013083; Protein modification; protein ubiquitination. CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (CCR4-associated factor 4) (E3 ubiquitin-protein ligase CNOT4) (Potential transcriptional repressor NOT4Hp) CNOT4 NOT4 Homo sapiens (Human) TR42003_c0_g1_i1 Q28GP7 SNX33_XENTR 2.00E-101 GO:0007154; GO:0036089; GO:0016023; GO:0030659; GO:0005829; GO:0016197; GO:0007032; GO:0019898; GO:0044351; GO:0097320; GO:0007067; GO:0000281; GO:0035091; GO:0015031 cell communication; cleavage furrow formation; cytoplasmic membrane-bounded vesicle; cytoplasmic vesicle membrane; cytosol; endosomal transport; endosome organization; extrinsic to membrane; macropinocytosis; membrane tubulation; mitosis; mitotic cytokinesis; phosphatidylinositol binding; protein transport IPR001683; IPR001452; IPR014536; IPR019497; Sorting nexin-33 (SH3 and PX domain-containing protein 3) snx33 sh3px3 TEgg059f08.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42004_c0_g4_i1 Q9VZW5 FMAR_DROME 5.00E-15 GO:0002209; GO:0007204; GO:0005887; GO:0008345; GO:0008188 behavioral defense response; elevation of cytosolic calcium ion concentration; integral to plasma membrane; larval locomotory behavior; neuropeptide receptor activity IPR000276; IPR017452; FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) TR42006_c0_g1_i1 Q5ZKU4 INT2_CHICK 7.00E-128 GO:0016021; GO:0032039; GO:0031965; GO:0016180 integral to membrane; integrator complex; nuclear membrane; snRNA processing IPR026236; Integrator complex subunit 2 (Int2) INTS2 RCJMB04_9c3 Gallus gallus (Chicken) TR42006_c0_g3_i1 Q55CB6 INT2_DICDI 2.00E-34 GO:0032039; GO:0016180 integrator complex; snRNA processing IPR026236; Integrator complex subunit 2 homolog ints2 DDB_G0271040 Dictyostelium discoideum (Slime mold) TR42006_c0_g3_i5 Q55CB6 INT2_DICDI 2.00E-34 GO:0032039; GO:0016180 integrator complex; snRNA processing IPR026236; Integrator complex subunit 2 homolog ints2 DDB_G0271040 Dictyostelium discoideum (Slime mold) TR42006_c0_g5_i2 Q9H0H0 INT2_HUMAN 9.00E-94 GO:0016021; GO:0032039; GO:0031965; GO:0016180 integral to membrane; integrator complex; nuclear membrane; snRNA processing IPR026236; Integrator complex subunit 2 (Int2) INTS2 KIAA1287 Homo sapiens (Human) TR42008_c0_g4_i1 Q7Z7H5 TMED4_HUMAN 3.00E-14 GO:0005789; GO:0016021; GO:0043123; GO:0015031; GO:0004871 endoplasmic reticulum membrane; integral to membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein transport; signal transducer activity IPR009038; Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (GMP25iso) (Putative NF-kappa-B-activating protein 156) (p24 family protein alpha-3) (p24alpha3) TMED4 ERS25 Homo sapiens (Human) TR42008_c0_g5_i1 B3NZM5 TMEDE_DROER 1.00E-85 GO:0009953; GO:0005789; GO:0016021; GO:0006810 dorsal/ventral pattern formation; endoplasmic reticulum membrane; integral to membrane; transport IPR009038; Transmembrane emp24 domain-containing protein eca eca GG17343 Drosophila erecta (Fruit fly) TR42008_c0_g5_i2 Q6CWW7 TMEDA_KLULA 3.00E-13 GO:0000139; GO:0005789; GO:0016021; GO:0015031; GO:0016192 Golgi membrane; endoplasmic reticulum membrane; integral to membrane; protein transport; vesicle-mediated transport IPR009038; Endoplasmic reticulum vesicle protein 25 ERV25 KLLA0B00935g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR42009_c0_g1_i1 Q2TLY1 MACO2_DANRE 8.00E-121 GO:0030424; GO:0016021; GO:0031965 axon; integral to membrane; nuclear membrane IPR019130; Macoilin-2 (Transmembrane protein 57b) tmem57b si:dkey-9g4.5 zgc:63610 Danio rerio (Zebrafish) (Brachydanio rerio) TR42009_c0_g3_i10 Q4V7D3 MACOI_RAT 8.00E-67 GO:0030424; GO:0016021; GO:0031965 axon; integral to membrane; nuclear membrane IPR019130; Macoilin (Transmembrane protein 57) Tmem57 Rattus norvegicus (Rat) TR42009_c0_g3_i8 Q4V7D3 MACOI_RAT 2.00E-67 GO:0030424; GO:0016021; GO:0031965 axon; integral to membrane; nuclear membrane IPR019130; Macoilin (Transmembrane protein 57) Tmem57 Rattus norvegicus (Rat) TR42010_c0_g2_i1 Q8R3B7 BRD8_MOUSE 4.00E-51 GO:0035267; GO:0043968; GO:0043967; GO:0005739; GO:0040008; GO:0006355; GO:0006351 "NuA4 histone acetyltransferase complex; histone H2A acetylation; histone H4 acetylation; mitochondrion; regulation of growth; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001487; Bromodomain-containing protein 8 Brd8 Mus musculus (Mouse) TR42010_c0_g2_i3 Q9LXA7 GTE2_ARATH 7.00E-09 GO:0005634; GO:0006355; GO:0006351 "nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001487; IPR027353; Transcription factor GTE2 (Bromodomain-containing protein GTE2) (Protein GLOBAL TRANSCRIPTION FACTOR GROUP E2) GTE2 At5g10550 F12B17_100 Arabidopsis thaliana (Mouse-ear cress) TR42010_c0_g2_i4 Q8R3B7 BRD8_MOUSE 1.00E-53 GO:0035267; GO:0043968; GO:0043967; GO:0005739; GO:0040008; GO:0006355; GO:0006351 "NuA4 histone acetyltransferase complex; histone H2A acetylation; histone H4 acetylation; mitochondrion; regulation of growth; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001487; Bromodomain-containing protein 8 Brd8 Mus musculus (Mouse) TR42010_c0_g2_i9 Q7ZUF2 BRD9_DANRE 4.00E-08 GO:0016568; GO:0070577; GO:0006355; GO:0006351 "chromatin modification; histone acetyl-lysine binding; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001487; IPR021900; Bromodomain-containing protein 9 brd9 Danio rerio (Zebrafish) (Brachydanio rerio) TR42011_c0_g1_i2 Q14746 COG2_HUMAN 0 GO:0000139; GO:0007030; GO:0005795; GO:0017119; GO:0006891; GO:0006886; GO:0009312; GO:0006486; GO:0008565 Q9H9E3 Golgi membrane; Golgi organization; Golgi stack; Golgi transport complex; intra-Golgi vesicle-mediated transport; intracellular protein transport; oligosaccharide biosynthetic process; protein glycosylation; protein transporter activity IPR009316; IPR024603; IPR024602; Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (Low density lipoprotein receptor defect C-complementing protein) COG2 LDLC Homo sapiens (Human) TR42011_c0_g1_i3 Q14746 COG2_HUMAN 3.00E-121 GO:0000139; GO:0007030; GO:0005795; GO:0017119; GO:0006891; GO:0006886; GO:0009312; GO:0006486; GO:0008565 Q9H9E3 Golgi membrane; Golgi organization; Golgi stack; Golgi transport complex; intra-Golgi vesicle-mediated transport; intracellular protein transport; oligosaccharide biosynthetic process; protein glycosylation; protein transporter activity IPR009316; IPR024603; IPR024602; Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (Low density lipoprotein receptor defect C-complementing protein) COG2 LDLC Homo sapiens (Human) TR42011_c0_g1_i4 Q21444 COG2_CAEEL 9.00E-06 GO:0000139; GO:0007030; GO:0035262; GO:0015031; GO:0030334 Golgi membrane; Golgi organization; gonad morphogenesis; protein transport; regulation of cell migration IPR009316; IPR024603; IPR024602; Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (LDLC protein homolog) cogc-2 cgo-2 cog-2 ldlc C06G3.10 Caenorhabditis elegans TR42012_c0_g1_i2 O95479 G6PE_HUMAN 1.00E-179 GO:0017057; GO:0050661; GO:0030246; GO:0005788; GO:0047936; GO:0004345; GO:0005739; GO:0006098; GO:0097305 6-phosphogluconolactonase activity; NADP binding; carbohydrate binding; endoplasmic reticulum lumen; glucose 1-dehydrogenase [NAD(P)] activity; glucose-6-phosphate dehydrogenase activity; mitochondrion; pentose-phosphate shunt; response to alcohol IPR005900; IPR001282; IPR019796; IPR022675; IPR022674; IPR006148; IPR016040; GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase (EC 1.1.1.47) (Hexose-6-phosphate dehydrogenase); 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)] H6PD GDH Homo sapiens (Human) TR42012_c0_g1_i3 O83490 6PGL_TREPA 1.00E-20 GO:0017057; GO:0006098 6-phosphogluconolactonase activity; pentose-phosphate shunt IPR005900; IPR006148; Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3. 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) pgl devB TP_0477 Treponema pallidum (strain Nichols) TR42012_c0_g1_i4 P46016 6PGL_NOSS1 2.00E-28 GO:0017057; GO:0043158; GO:0006098 6-phosphogluconolactonase activity; heterocyst differentiation; pentose-phosphate shunt IPR005900; IPR006148; Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3. 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) pgl devB alr1602 Nostoc sp. (strain PCC 7120 / UTEX 2576) TR42012_c0_g1_i5 Q27638 G6PD_DROYA 2.00E-49 GO:0050661; GO:0006739; GO:0051156; GO:0004345; GO:0006098 NADP binding; NADP metabolic process; glucose 6-phosphate metabolic process; glucose-6-phosphate dehydrogenase activity; pentose-phosphate shunt IPR001282; IPR019796; IPR022675; IPR022674; IPR016040; Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) (Fragment) Zw G6pd Drosophila yakuba (Fruit fly) TR42012_c0_g1_i6 Q8CFX1 G6PE_MOUSE 6.00E-53 GO:0017057; GO:0050661; GO:0005788; GO:0047936; GO:0004345; GO:0006098 6-phosphogluconolactonase activity; NADP binding; endoplasmic reticulum lumen; glucose 1-dehydrogenase [NAD(P)] activity; glucose-6-phosphate dehydrogenase activity; pentose-phosphate shunt IPR005900; IPR001282; IPR019796; IPR022675; IPR022674; IPR006148; IPR016040; GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase (EC 1.1.1.47) (Hexose-6-phosphate dehydrogenase); 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)] H6pd Mus musculus (Mouse) TR42012_c0_g1_i7 P74618 6PGL_SYNY3 9.00E-30 GO:0017057; GO:0006098 6-phosphogluconolactonase activity; pentose-phosphate shunt IPR005900; IPR006148; Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3. 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) pgl devB sll1479 Synechocystis sp. (strain PCC 6803 / Kazusa) TR42013_c0_g1_i1 Q9FYP9 IMA2_ORYSJ 7.00E-18 GO:0005634; GO:0048471; GO:0006606; GO:0008565 nucleus; perinuclear region of cytoplasm; protein import into nucleus; protein transporter activity IPR011989; IPR016024; IPR000225; IPR024931; Importin subunit alpha-2 Os01g0158000 LOC_Os01g06470 P0011G08.44 Oryza sativa subsp. japonica (Rice) TR42013_c0_g2_i1 O35345 IMA7_MOUSE 4.00E-169 GO:0005737; GO:0060135; GO:0005634; GO:0045944; GO:0006606; GO:0008565 cytoplasm; maternal process involved in female pregnancy; nucleus; positive regulation of transcription from RNA polymerase II promoter; protein import into nucleus; protein transporter activity IPR011989; IPR016024; IPR000225; IPR002652; IPR024931; Importin subunit alpha-7 (Importin alpha-S2) (Karyopherin subunit alpha-6) Kpna6 Kpna5 Mus musculus (Mouse) TR42013_c0_g2_i2 Q96321 IMA1_ARATH 4.00E-108 GO:0005618; GO:0005829; GO:0005635; GO:0005730; GO:0006606; GO:0008565 F8RP38 cell wall; cytosol; nuclear envelope; nucleolus; protein import into nucleus; protein transporter activity IPR011989; IPR016024; IPR000225; IPR002652; IPR024931; Importin subunit alpha-1 (Karyopherin subunit alpha-1) (KAP-alpha-1) KAP1 At3g06720 F3E22.14 T8E24.1 Arabidopsis thaliana (Mouse-ear cress) TR42013_c0_g2_i3 O35345 IMA7_MOUSE 4.00E-169 GO:0005737; GO:0060135; GO:0005634; GO:0045944; GO:0006606; GO:0008565 cytoplasm; maternal process involved in female pregnancy; nucleus; positive regulation of transcription from RNA polymerase II promoter; protein import into nucleus; protein transporter activity IPR011989; IPR016024; IPR000225; IPR002652; IPR024931; Importin subunit alpha-7 (Importin alpha-S2) (Karyopherin subunit alpha-6) Kpna6 Kpna5 Mus musculus (Mouse) TR42014_c1_g3_i2 P11260 TR22_MOUSE 1.00E-30 GO:0003723 RNA binding IPR004244; Putative transposase element L1Md-A101/L1Md-A102/L1Md-A2 Mus musculus (Mouse) TR42014_c1_g4_i1 Q587J6 LITD1_MOUSE 9.00E-20 IPR004244; LINE-1 type transposase domain-containing protein 1 (ES cell-associated protein 11) L1td1 Ecat11 Mus musculus (Mouse) TR42016_c1_g1_i2 Q6DBQ8 GLTD1_DANRE 1.00E-29 GO:0005794; GO:1902387; GO:1902389; GO:1902388; GO:0005829; GO:0010008; GO:0051861; GO:0046836; GO:0017089; GO:0005640; GO:0005886 Golgi apparatus; ceramide 1-phosphate binding; ceramide 1-phosphate transport; ceramide 1-phosphate transporter activity; cytosol; endosome membrane; glycolipid binding; glycolipid transport; glycolipid transporter activity; nuclear outer membrane; plasma membrane IPR014830; Ceramide-1-phosphate transfer protein (Glycolipid transfer protein domain-containing protein 1) (CPTP) gltpd1 zgc:92000 Danio rerio (Zebrafish) (Brachydanio rerio) TR42016_c1_g3_i5 Q5TA50 GLTD1_HUMAN 4.00E-10 GO:0005794; GO:1902387; GO:1902389; GO:1902388; GO:0005829; GO:0010008; GO:0051861; GO:0017089; GO:0005640; GO:0005886 Golgi apparatus; ceramide 1-phosphate binding; ceramide 1-phosphate transport; ceramide 1-phosphate transporter activity; cytosol; endosome membrane; glycolipid binding; glycolipid transporter activity; nuclear outer membrane; plasma membrane IPR014830; Ceramide-1-phosphate transfer protein (Glycolipid transfer protein domain-containing protein 1) (CPTP) GLTPD1 Homo sapiens (Human) TR42017_c0_g1_i1 O75694 NU155_HUMAN 0 GO:0005975; GO:0019221; GO:0015758; GO:0006406; GO:0007077; GO:0005635; GO:0031965; GO:0005643; GO:0006606; GO:0086014; GO:0010827; GO:0044281; GO:0017056; GO:0055085; GO:0005215; GO:0016032 carbohydrate metabolic process; cytokine-mediated signaling pathway; glucose transport; mRNA export from nucleus; mitotic nuclear envelope disassembly; nuclear envelope; nuclear membrane; nuclear pore; protein import into nucleus; regulation of atrial cardiac muscle cell action potential; regulation of glucose transport; small molecule metabolic process; structural constituent of nuclear pore; transmembrane transport; transporter activity; viral process IPR007187; IPR014908; IPR004870; Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) NUP155 KIAA0791 Homo sapiens (Human) TR42019_c3_g1_i2 Q5E9R2 PLCD_BOVIN 3.00E-96 GO:0003841; GO:0016024; GO:0016021 1-acylglycerol-3-phosphate O-acyltransferase activity; CDP-diacylglycerol biosynthetic process; integral to membrane IPR002123; Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 4) (1-AGP acyltransferase 4) (1-AGPAT 4) (Lysophosphatidic acid acyltransferase delta) (LPAAT-delta) AGPAT4 Bos taurus (Bovine) TR42019_c4_g2_i1 P43116 PE2R2_HUMAN 2.00E-16 GO:0007189; GO:0071380; GO:0005887; GO:0004957; GO:0042127; GO:0032496 adenylate cyclase-activating G-protein coupled receptor signaling pathway; cellular response to prostaglandin E stimulus; integral to plasma membrane; prostaglandin E receptor activity; regulation of cell proliferation; response to lipopolysaccharide IPR000276; IPR017452; IPR008365; IPR001923; Prostaglandin E2 receptor EP2 subtype (PGE receptor EP2 subtype) (PGE2 receptor EP2 subtype) (Prostanoid EP2 receptor) PTGER2 Homo sapiens (Human) TR42019_c4_g2_i2 Q8NGU2 OR9A4_HUMAN 5.00E-07 GO:0004930; GO:0050911; GO:0016021; GO:0004984; GO:0005886 G-protein coupled receptor activity; detection of chemical stimulus involved in sensory perception of smell; integral to membrane; olfactory receptor activity; plasma membrane IPR000276; IPR017452; IPR000725; Olfactory receptor 9A4 (Olfactory receptor OR7-1) OR9A4 Homo sapiens (Human) TR42019_c4_g2_i3 Q8MJ08 PE2R4_BOVIN 4.00E-27 GO:0007188; GO:0016021; GO:2000420; GO:0050728; GO:0033624; GO:0005886; GO:0004957 adenylate cyclase-modulating G-protein coupled receptor signaling pathway; integral to membrane; negative regulation of eosinophil extravasation; negative regulation of inflammatory response; negative regulation of integrin activation; plasma membrane; prostaglandin E receptor activity IPR000276; IPR017452; IPR001758; IPR008365; IPR001244; Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 Bos taurus (Bovine) TR42020_c0_g2_i1 P42325 NCAH_DROME 3.00E-125 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Neurocalcin homolog (DrosNCa) Nca CG7641 Drosophila melanogaster (Fruit fly) TR42020_c0_g2_i2 A8I1Q0 CALM_HETTR 3.00E-08 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Heterocapsa triquetra (Dinoflagellate) (Glenodinium triquetrum) TR42021_c1_g1_i3 P00516 KGP1_BOVIN 0 GO:0005524; GO:0030553; GO:0004692; GO:0005246; GO:0005829; GO:0090331; GO:0043087 ATP binding; cGMP binding; cGMP-dependent protein kinase activity; calcium channel regulator activity; cytosol; negative regulation of platelet aggregation; regulation of GTPase activity IPR000961; IPR016232; IPR002374; IPR018490; IPR018488; IPR000595; IPR011009; IPR000719; IPR017441; IPR014710; IPR002290; IPR008271; cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) PRKG1 PRKG1B PRKGR1A PRKGR1B Bos taurus (Bovine) TR42023_c3_g1_i1 Q1LVS8 SVOPL_DANRE 4.00E-11 GO:0016021; GO:0022857 integral to membrane; transmembrane transporter activity IPR011701; IPR020846; IPR016196; IPR005828; Putative transporter SVOPL (SVOP-like protein) svopl si:dkeyp-27e10.2 zgc:101741 Danio rerio (Zebrafish) (Brachydanio rerio) TR42023_c3_g1_i2 Q9Z0E8 S22A5_MOUSE 2.00E-31 GO:0005524; GO:0007512; GO:0016324; GO:0031526; GO:0009437; GO:0015226; GO:0016021; GO:0007626; GO:0007005; GO:0048608; GO:0006814; GO:0015293 ATP binding; adult heart development; apical plasma membrane; brush border membrane; carnitine metabolic process; carnitine transmembrane transporter activity; integral to membrane; locomotory behavior; mitochondrion organization; reproductive structure development; sodium ion transport; symporter activity IPR020846; IPR016196; IPR004749; IPR005828; IPR005829; Solute carrier family 22 member 5 (High-affinity sodium-dependent carnitine cotransporter) (Organic cation/carnitine transporter 2) Slc22a5 Octn2 Mus musculus (Mouse) TR42023_c6_g1_i1 Q9R1U7 S22A8_RAT 1.00E-10 GO:0016323; GO:0034635; GO:0005452; GO:0016021; GO:0008514; GO:0015651; GO:0031427; GO:0009636 basolateral plasma membrane; glutathione transport; inorganic anion exchanger activity; integral to membrane; organic anion transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity; response to methotrexate; response to toxic substance IPR020846; IPR016196; IPR004749; IPR005828; IPR005829; Solute carrier family 22 member 8 (Organic anion transporter 3) (rOat3) Slc22a8 Oat3 Rattus norvegicus (Rat) TR42023_c7_g1_i1 Q9Z0E8 S22A5_MOUSE 1.00E-07 GO:0005524; GO:0007512; GO:0016324; GO:0031526; GO:0009437; GO:0015226; GO:0016021; GO:0007626; GO:0007005; GO:0048608; GO:0006814; GO:0015293 ATP binding; adult heart development; apical plasma membrane; brush border membrane; carnitine metabolic process; carnitine transmembrane transporter activity; integral to membrane; locomotory behavior; mitochondrion organization; reproductive structure development; sodium ion transport; symporter activity IPR020846; IPR016196; IPR004749; IPR005828; IPR005829; Solute carrier family 22 member 5 (High-affinity sodium-dependent carnitine cotransporter) (Organic cation/carnitine transporter 2) Slc22a5 Octn2 Mus musculus (Mouse) TR42024_c1_g3_i1 Q66L42 M3K10_MOUSE 5.00E-15 GO:0005524; GO:0004709; GO:0000165; GO:0000186; GO:0045892; GO:0004672; GO:0003714 "ATP binding; MAP kinase kinase kinase activity; MAPK cascade; activation of MAPKK activity; negative regulation of transcription, DNA-dependent; protein kinase activity; transcription corepressor activity" IPR011009; IPR016231; IPR015785; IPR000719; IPR017441; IPR001245; IPR008271; IPR001452; Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) Map3k10 Mus musculus (Mouse) TR42024_c1_g3_i3 Q2MHE4 HT1_ARATH 3.00E-23 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR001245; IPR008271; Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High leaf temperature protein 1) HT1 At1g62400 F24O1.13 Arabidopsis thaliana (Mouse-ear cress) TR42024_c1_g3_i4 Q552C1 Y9957_DICDI 3.00E-14 GO:0005524; GO:0005543; GO:0004674 ATP binding; phospholipid binding; protein serine/threonine kinase activity IPR011009; IPR011993; IPR001849; IPR000719; IPR001245; IPR008271; Probable serine/threonine-protein kinase DDB_G0276181 (EC 2.7.11.1) DDB_G0276181 Dictyostelium discoideum (Slime mold) TR42024_c1_g5_i1 Q54HW1 PSD10_DICDI 4.00E-16 IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) psmD10 DDB_G0289189 Dictyostelium discoideum (Slime mold) TR42024_c1_g5_i2 Q3SWY2 ILK_BOVIN 4.00E-150 GO:0005524; GO:0005925; GO:0030027; GO:0005886; GO:0004674; GO:0009966; GO:0030017 ATP binding; focal adhesion; lamellipodium; plasma membrane; protein serine/threonine kinase activity; regulation of signal transduction; sarcomere IPR002110; IPR020683; IPR016253; IPR011009; IPR000719; IPR001245; Integrin-linked protein kinase (EC 2.7.11.1) ILK Bos taurus (Bovine) TR42024_c1_g5_i3 O60237 MYPT2_HUMAN 2.00E-15 GO:0000086; GO:0015629; GO:0005737; GO:0008047; GO:0005654; GO:0005886; GO:0006937; GO:0007165 G2/M transition of mitotic cell cycle; actin cytoskeleton; cytoplasm; enzyme activator activity; nucleoplasm; plasma membrane; regulation of muscle contraction; signal transduction IPR002110; IPR020683; IPR017401; Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) PPP1R12B MYPT2 Homo sapiens (Human) TR42025_c0_g1_i1 P70196 TRAF6_MOUSE 2.00E-27 GO:0035631; GO:0007249; GO:0007254; GO:0050852; GO:0042088; GO:0007250; GO:0019886; GO:0045453; GO:0005938; GO:0048468; GO:0005829; GO:0070498; GO:0009898; GO:0005811; GO:0043011; GO:0000122; GO:0001843; GO:0031965; GO:0042475; GO:0001503; GO:0030316; GO:0048471; GO:0043123; GO:0043507; GO:0051092; GO:0002726; GO:0042102; GO:0045084; GO:0032743; GO:0045410; GO:0031666; GO:0045672; GO:0048661; GO:0045944; GO:2000679; GO:0070534; GO:0051865; GO:0006461; GO:0042981; GO:0051023; GO:0004871; GO:0004842; GO:0008270 P27512; Q9QZH6; P17879; Q62406-1; Q61084; Q62227; P35235; Q793I8; O35305; Q8C0E5; Q8N7N6; Q3UDK1; P62991 CD40 receptor complex; I-kappaB kinase/NF-kappaB cascade; JNK cascade; T cell receptor signaling pathway; T-helper 1 type immune response; activation of NF-kappaB-inducing kinase activity; antigen processing and presentation of exogenous peptide antigen via MHC class II; bone resorption; cell cortex; cell development; cytosol; interleukin-1-mediated signaling pathway; internal side of plasma membrane; lipid particle; myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter; neural tube closure; nuclear membrane; odontogenesis of dentin-containing tooth; ossification; osteoclast differentiation; perinuclear region of cytoplasm; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JUN kinase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell cytokine production; positive regulation of T cell proliferation; positive regulation of interleukin-12 biosynthetic process; positive regulation of interleukin-2 production; positive regulation of interleukin-6 biosynthetic process; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of osteoclast differentiation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription regulatory region DNA binding; protein K63-linked ubiquitination; protein autoubiquitination; protein complex assembly; regulation of apoptotic process; regulation of immunoglobulin secretion; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR012227; IPR008974; IPR027139; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. TNF receptor-associated factor 6 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF6) Traf6 Mus musculus (Mouse) TR42025_c0_g1_i2 Q12933 TRAF2_HUMAN 2.00E-87 GO:0005174; GO:0035631; GO:0007250; GO:0006919; GO:0097190; GO:0043623; GO:0005829; GO:0045087; GO:0009898; GO:0043507; GO:0051092; GO:0050870; GO:0002726; GO:2001238; GO:0032743; GO:0090073; GO:0070534; GO:0051865; GO:0030163; GO:0070207; GO:2001239; GO:0051023; GO:0004871; GO:0046625; GO:0033209; GO:0004842; GO:0008270 Itself; P88961; P54253; Q13490; Q13489; O08736; O75460; P09211; P09022; P07174; Q13546; Q92844; Q9H2K8; Q9NP84; Q92956; Q15628; P70191; Q9Y4K3; Q6FIF0 CD40 receptor binding; CD40 receptor complex; activation of NF-kappaB-inducing kinase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic signaling pathway; cellular protein complex assembly; cytosol; innate immune response; internal side of plasma membrane; positive regulation of JUN kinase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell activation; positive regulation of T cell cytokine production; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of interleukin-2 production; positive regulation of protein homodimerization activity; protein K63-linked ubiquitination; protein autoubiquitination; protein catabolic process; protein homotrimerization; regulation of extrinsic apoptotic signaling pathway in absence of ligand; regulation of immunoglobulin secretion; signal transducer activity; sphingolipid binding; tumor necrosis factor-mediated signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR012227; IPR008974; IPR027133; IPR018957; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. TNF receptor-associated factor 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3) TRAF2 TRAP3 Homo sapiens (Human) TR42025_c0_g1_i3 B5DF45 TRAF6_RAT 3.00E-26 GO:0035631; GO:0007249; GO:0007254; GO:0050852; GO:0042088; GO:0007250; GO:0019886; GO:0045453; GO:0005938; GO:0048468; GO:0005829; GO:0070498; GO:0009898; GO:0005811; GO:0043011; GO:0000122; GO:0001843; GO:0031965; GO:0042475; GO:0001503; GO:0030316; GO:0048471; GO:0043123; GO:0043507; GO:0051092; GO:0002726; GO:0042102; GO:0045084; GO:0032743; GO:0045410; GO:0031666; GO:0045672; GO:0048661; GO:0045944; GO:2000679; GO:0070534; GO:0051865; GO:0043234; GO:0006461; GO:0042981; GO:0051023; GO:0004871; GO:0004842; GO:0008270 CD40 receptor complex; I-kappaB kinase/NF-kappaB cascade; JNK cascade; T cell receptor signaling pathway; T-helper 1 type immune response; activation of NF-kappaB-inducing kinase activity; antigen processing and presentation of exogenous peptide antigen via MHC class II; bone resorption; cell cortex; cell development; cytosol; interleukin-1-mediated signaling pathway; internal side of plasma membrane; lipid particle; myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter; neural tube closure; nuclear membrane; odontogenesis of dentin-containing tooth; ossification; osteoclast differentiation; perinuclear region of cytoplasm; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JUN kinase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell cytokine production; positive regulation of T cell proliferation; positive regulation of interleukin-12 biosynthetic process; positive regulation of interleukin-2 production; positive regulation of interleukin-6 biosynthetic process; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of osteoclast differentiation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription regulatory region DNA binding; protein K63-linked ubiquitination; protein autoubiquitination; protein complex; protein complex assembly; regulation of apoptotic process; regulation of immunoglobulin secretion; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR012227; IPR008974; IPR027139; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. TNF receptor-associated factor 6 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF6) Traf6 Rattus norvegicus (Rat) TR42025_c0_g1_i4 Q55GA8 Y7744_DICDI 7.00E-11 GO:0005737; GO:0008270 cytoplasm; zinc ion binding IPR008974; IPR013083; IPR001293; TNF receptor-associated factor family protein DDB_G0267744 DDB_G0267744 Dictyostelium discoideum (Slime mold) TR42025_c0_g1_i5 P39429 TRAF2_MOUSE 3.00E-90 GO:0035631; GO:0007250; GO:0006915; GO:0043623; GO:0005737; GO:0009898; GO:0043066; GO:0043507; GO:0051092; GO:0002726; GO:2001238; GO:0032743; GO:0090073; GO:0070534; GO:0051865; GO:0030163; GO:0070207; GO:0051023; GO:0046625; GO:0033209; GO:0004842; GO:0008270 O08863; Q920A9; Q62073; Q8CDB0; P70347-1; Q60769; O35305; P47741; Q60803 CD40 receptor complex; activation of NF-kappaB-inducing kinase activity; apoptotic process; cellular protein complex assembly; cytoplasm; internal side of plasma membrane; negative regulation of apoptotic process; positive regulation of JUN kinase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell cytokine production; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of interleukin-2 production; positive regulation of protein homodimerization activity; protein K63-linked ubiquitination; protein autoubiquitination; protein catabolic process; protein homotrimerization; regulation of immunoglobulin secretion; sphingolipid binding; tumor necrosis factor-mediated signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR012227; IPR008974; IPR027133; IPR018957; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. TNF receptor-associated factor 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF2) Traf2 Mus musculus (Mouse) TR42026_c0_g3_i1 Q9UIJ5 ZDHC2_HUMAN 9.00E-95 GO:0005887; GO:0016409; GO:0018345; GO:0055038; GO:0008270 integral to plasma membrane; palmitoyltransferase activity; protein palmitoylation; recycling endosome membrane; zinc ion binding IPR001594; Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372) ZDHHC2 REAM REC ZNF372 Homo sapiens (Human) TR42029_c1_g1_i1 P31424 GRM5_RAT 4.00E-29 GO:0004930; GO:0030165; GO:0001639; GO:0000185; GO:0097449; GO:0005516; GO:0005737; GO:0043198; GO:0043197; GO:0002029; GO:0051482; GO:0016021; GO:0007612; GO:0007626; GO:0040013; GO:0048015; GO:0048170; GO:0014069; GO:0045211; GO:0007205; GO:0006468; GO:0006355; GO:0007268 P29274; Q8R4T5; P63088 "G-protein coupled receptor activity; PDZ domain binding; PLC activating G-protein coupled glutamate receptor activity; activation of MAPKKK activity; astrocyte projection; calmodulin binding; cytoplasm; dendritic shaft; dendritic spine; desensitization of G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; integral to membrane; learning; locomotory behavior; negative regulation of locomotion; phosphatidylinositol-mediated signaling; positive regulation of long-term neuronal synaptic plasticity; postsynaptic density; postsynaptic membrane; protein kinase C-activating G-protein coupled receptor signaling pathway; protein phosphorylation; regulation of transcription, DNA-dependent; synaptic transmission" IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR000162; IPR000202; IPR019588; IPR028082; Metabotropic glutamate receptor 5 (mGluR5) Grm5 Gprc1e Mglur5 Rattus norvegicus (Rat) TR42029_c1_g1_i2 Q14416 GRM2_HUMAN 4.00E-25 GO:0004930; GO:0030424; GO:0005246; GO:0030054; GO:0030425; GO:0008066; GO:0014047; GO:0001641; GO:0005887; GO:0005622; GO:0007194; GO:0042734; GO:0007268 G-protein coupled receptor activity; axon; calcium channel regulator activity; cell junction; dendrite; glutamate receptor activity; glutamate secretion; group II metabotropic glutamate receptor activity; integral to plasma membrane; intracellular; negative regulation of adenylate cyclase activity; presynaptic membrane; synaptic transmission IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR000162; IPR001458; IPR028082; Metabotropic glutamate receptor 2 (mGluR2) GRM2 GPRC1B MGLUR2 Homo sapiens (Human) TR42029_c1_g1_i5 P91685 GRM_DROME 3.00E-11 GO:0015485; GO:0016595; GO:0001641; GO:0005887; GO:0045121; GO:0007528; GO:0051966 "cholesterol binding; glutamate binding; group II metabotropic glutamate receptor activity; integral to plasma membrane; membrane raft; neuromuscular junction development; regulation of synaptic transmission, glutamatergic" IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR000162; IPR028082; Metabotropic glutamate receptor (DmGluRA) mGluRA Glu-RA GluRA CG11144 Drosophila melanogaster (Fruit fly) TR42033_c2_g1_i1 P51592 HYD_DROME 0 GO:0003723; GO:0048749; GO:0005737; GO:0007455; GO:0008585; GO:0007446; GO:0007112; GO:0045879; GO:0005634; GO:0042787; GO:0030162; GO:0007289; GO:0004842; GO:0008270 RNA binding; compound eye development; cytoplasm; eye-antennal disc morphogenesis; female gonad development; imaginal disc growth; male meiosis cytokinesis; negative regulation of smoothened signaling pathway; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of proteolysis; spermatid nucleus differentiation; ubiquitin-protein ligase activity; zinc ion binding IPR024725; IPR000569; IPR002004; IPR009091; IPR015940; IPR003126; IPR013993; E3 ubiquitin-protein ligase hyd (EC 6.3.2.-) (Protein hyperplastic discs) hyd l(3)C43 CG9484 Drosophila melanogaster (Fruit fly) TR42033_c2_g1_i3 Q8H0T4 UPL2_ARATH 4.00E-24 GO:0005829; GO:0005739; GO:0005634; GO:0042787; GO:0004842 cytosol; mitochondrion; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR011989; IPR016024; IPR025527; IPR010309; IPR010314; IPR000569; IPR009060; IPR015940; IPR000449; IPR003903; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UPL2 (Ubiquitin-protein ligase 2) (EC 6.3.2.-) UPL2 At1g70320 F17O7.14/F17O7.15 Arabidopsis thaliana (Mouse-ear cress) TR42033_c2_g1_i5 P51592 HYD_DROME 0 GO:0003723; GO:0048749; GO:0005737; GO:0007455; GO:0008585; GO:0007446; GO:0007112; GO:0045879; GO:0005634; GO:0042787; GO:0030162; GO:0007289; GO:0004842; GO:0008270 RNA binding; compound eye development; cytoplasm; eye-antennal disc morphogenesis; female gonad development; imaginal disc growth; male meiosis cytokinesis; negative regulation of smoothened signaling pathway; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of proteolysis; spermatid nucleus differentiation; ubiquitin-protein ligase activity; zinc ion binding IPR024725; IPR000569; IPR002004; IPR009091; IPR015940; IPR003126; IPR013993; E3 ubiquitin-protein ligase hyd (EC 6.3.2.-) (Protein hyperplastic discs) hyd l(3)C43 CG9484 Drosophila melanogaster (Fruit fly) TR42033_c2_g1_i8 Q80TP3 UBR5_MOUSE 9.00E-167 GO:0006281; GO:0003723; GO:0005737; GO:2000780; GO:1901315; GO:0005634; GO:0050847; GO:0042787; GO:0006974; GO:0004842; GO:0008270 DNA repair; RNA binding; cytoplasm; negative regulation of double-strand break repair; negative regulation of histone H2A K63-linked ubiquitination; nucleus; progesterone receptor signaling pathway; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; response to DNA damage stimulus; ubiquitin-protein ligase activity; zinc ion binding IPR024725; IPR000569; IPR002004; IPR009091; IPR003126; IPR013993; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase UBR5 (EC 6.3.2.-) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog)" Ubr5 Edd Edd1 Kiaa0896 Mus musculus (Mouse) TR42034_c4_g1_i1 O57683 SF3B1_XENLA 5.00E-87 GO:0008380; GO:0006397; GO:0005681 RNA splicing; mRNA processing; spliceosomal complex IPR011989; IPR016024; IPR015016; Splicing factor 3B subunit 1 (146 kDa nuclear protein) (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) sf3b1 Xenopus laevis (African clawed frog) TR42034_c4_g2_i2 O75533 SF3B1_HUMAN 0 GO:0005689; GO:0009952; GO:0071013; GO:0003682; GO:0000398; GO:0016607; GO:0005654 Q96I25 "U12-type spliceosomal complex; anterior/posterior pattern specification; catalytic step 2 spliceosome; chromatin binding; mRNA splicing, via spliceosome; nuclear speck; nucleoplasm" IPR011989; IPR016024; IPR015016; Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) SF3B1 SAP155 Homo sapiens (Human) TR42034_c4_g2_i3 P49955 SF3B1_YEAST 0 GO:0005686; GO:0071004; GO:0003729; GO:0000245 Q04693; P0C074 U2 snRNP; U2-type prespliceosome; mRNA binding; spliceosomal complex assembly IPR011989; IPR016024; U2 snRNP component HSH155 HSH155 YMR288W YM8021.14 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42035_c0_g1_i1 P98069 BMPH_STRPU 4.00E-18 GO:0005509; GO:0004222; GO:0007275; GO:0006508; GO:0008270 calcium ion binding; metalloendopeptidase activity; multicellular organismal development; proteolysis; zinc ion binding IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Bone morphogenetic protein 1 homolog (EC 3.4.24.-) (SUBMP) Strongylocentrotus purpuratus (Purple sea urchin) TR42038_c0_g1_i1 Q23924 COPB_DICDI 3.00E-141 GO:0030126; GO:0005794; GO:0006886; GO:0048471; GO:0005198; GO:0016192 COPI vesicle coat; Golgi apparatus; intracellular protein transport; perinuclear region of cytoplasm; structural molecule activity; vesicle-mediated transport IPR011989; IPR016024; IPR002553; IPR011710; IPR016460; Coatomer subunit beta (Beta-coat protein) (Beta-COP) copb rcdC veg125 DDB_G0284735 Dictyostelium discoideum (Slime mold) TR42038_c0_g2_i1 Q5ZIA5 COPB_CHICK 0 GO:0030126; GO:0006886; GO:0005198; GO:0016192 COPI vesicle coat; intracellular protein transport; structural molecule activity; vesicle-mediated transport IPR011989; IPR016024; IPR002553; IPR011710; IPR016460; Coatomer subunit beta (Beta-coat protein) (Beta-COP) COPB1 COPB RCJMB04_28l17 Gallus gallus (Chicken) TR42038_c0_g2_i2 Q23924 COPB_DICDI 4.00E-110 GO:0030126; GO:0005794; GO:0006886; GO:0048471; GO:0005198; GO:0016192 COPI vesicle coat; Golgi apparatus; intracellular protein transport; perinuclear region of cytoplasm; structural molecule activity; vesicle-mediated transport IPR011989; IPR016024; IPR002553; IPR011710; IPR016460; Coatomer subunit beta (Beta-coat protein) (Beta-COP) copb rcdC veg125 DDB_G0284735 Dictyostelium discoideum (Slime mold) TR42038_c0_g2_i3 Q5ZIA5 COPB_CHICK 0 GO:0030126; GO:0006886; GO:0005198; GO:0016192 COPI vesicle coat; intracellular protein transport; structural molecule activity; vesicle-mediated transport IPR011989; IPR016024; IPR002553; IPR011710; IPR016460; Coatomer subunit beta (Beta-coat protein) (Beta-COP) COPB1 COPB RCJMB04_28l17 Gallus gallus (Chicken) TR42038_c0_g2_i4 Q6FM46 COPB_CANGA 4.00E-143 GO:0030126; GO:0006886; GO:0005198; GO:0016192 COPI vesicle coat; intracellular protein transport; structural molecule activity; vesicle-mediated transport IPR011989; IPR016024; IPR002553; IPR011710; IPR016460; Coatomer subunit beta (Beta-coat protein) (Beta-COP) SEC26 CAGL0K11088g Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) TR42039_c0_g2_i1 P43249 GRK5_BOVIN 0 GO:0005524; GO:0004703; GO:0016055; GO:0006915; GO:0005737; GO:0008289; GO:0043066; GO:0005634; GO:0005886; GO:0046777; GO:0004674; GO:0007217; GO:0038032 ATP binding; G-protein coupled receptor kinase activity; Wnt receptor signaling pathway; apoptotic process; cytoplasm; lipid binding; negative regulation of apoptotic process; nucleus; plasma membrane; protein autophosphorylation; protein serine/threonine kinase activity; tachykinin receptor signaling pathway; termination of G-protein coupled receptor signaling pathway IPR000961; IPR000239; IPR011009; IPR000719; IPR017441; IPR016137; IPR000342; IPR002290; IPR008271; G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) GRK5 GPRK5 Bos taurus (Bovine) TR42039_c0_g2_i2 P43249 GRK5_BOVIN 0 GO:0005524; GO:0004703; GO:0016055; GO:0006915; GO:0005737; GO:0008289; GO:0043066; GO:0005634; GO:0005886; GO:0046777; GO:0004674; GO:0007217; GO:0038032 ATP binding; G-protein coupled receptor kinase activity; Wnt receptor signaling pathway; apoptotic process; cytoplasm; lipid binding; negative regulation of apoptotic process; nucleus; plasma membrane; protein autophosphorylation; protein serine/threonine kinase activity; tachykinin receptor signaling pathway; termination of G-protein coupled receptor signaling pathway IPR000961; IPR000239; IPR011009; IPR000719; IPR017441; IPR016137; IPR000342; IPR002290; IPR008271; G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) GRK5 GPRK5 Bos taurus (Bovine) TR42039_c0_g2_i3 Q62833 GRK5_RAT 0 GO:0005524; GO:0004703; GO:0016055; GO:0006915; GO:0005737; GO:0002029; GO:0008289; GO:0043066; GO:0005634; GO:0005886; GO:0046777; GO:0042493; GO:0038032 ATP binding; G-protein coupled receptor kinase activity; Wnt receptor signaling pathway; apoptotic process; cytoplasm; desensitization of G-protein coupled receptor protein signaling pathway; lipid binding; negative regulation of apoptotic process; nucleus; plasma membrane; protein autophosphorylation; response to drug; termination of G-protein coupled receptor signaling pathway IPR000961; IPR000239; IPR011009; IPR000719; IPR017441; IPR016137; IPR000342; IPR002290; G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) Grk5 Gprk5 Rattus norvegicus (Rat) TR42039_c0_g2_i4 Q8VEB1 GRK5_MOUSE 0 GO:0005524; GO:0004703; GO:0016055; GO:0006915; GO:0005737; GO:0008289; GO:0043066; GO:0005634; GO:0005886; GO:0046777; GO:0004674; GO:0007217; GO:0038032 ATP binding; G-protein coupled receptor kinase activity; Wnt receptor signaling pathway; apoptotic process; cytoplasm; lipid binding; negative regulation of apoptotic process; nucleus; plasma membrane; protein autophosphorylation; protein serine/threonine kinase activity; tachykinin receptor signaling pathway; termination of G-protein coupled receptor signaling pathway IPR000961; IPR000239; IPR011009; IPR000719; IPR017441; IPR016137; IPR000342; IPR002290; G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) Grk5 Gprk5 Mus musculus (Mouse) TR42039_c0_g2_i5 P43249 GRK5_BOVIN 0 GO:0005524; GO:0004703; GO:0016055; GO:0006915; GO:0005737; GO:0008289; GO:0043066; GO:0005634; GO:0005886; GO:0046777; GO:0004674; GO:0007217; GO:0038032 ATP binding; G-protein coupled receptor kinase activity; Wnt receptor signaling pathway; apoptotic process; cytoplasm; lipid binding; negative regulation of apoptotic process; nucleus; plasma membrane; protein autophosphorylation; protein serine/threonine kinase activity; tachykinin receptor signaling pathway; termination of G-protein coupled receptor signaling pathway IPR000961; IPR000239; IPR011009; IPR000719; IPR017441; IPR016137; IPR000342; IPR002290; IPR008271; G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) GRK5 GPRK5 Bos taurus (Bovine) TR42041_c2_g1_i1 Q9D7M8 RPB4_MOUSE 1.00E-07 GO:0005665; GO:0003899; GO:0000166; GO:0006366 "DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase activity; nucleotide binding; transcription from RNA polymerase II promoter" IPR010997; IPR005574; IPR006590; DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) Polr2d Mus musculus (Mouse) TR42044_c0_g2_i2 Q5F3Z3 UB2V2_CHICK 6.00E-51 GO:0000729; GO:0031372; GO:0016881; GO:0005634 DNA double-strand break processing; UBC13-MMS2 complex; acid-amino acid ligase activity; nucleus IPR000608; IPR016135; Ubiquitin-conjugating enzyme E2 variant 2 UBE2V2 RCJMB04_4b12 Gallus gallus (Chicken) TR42045_c1_g5_i4 Q8NEZ4 MLL3_HUMAN 3.00E-17 GO:0003677; GO:0042800; GO:0035097; GO:0035556; GO:0006355; GO:0006351; GO:0008270 Q14686 "DNA binding; histone methyltransferase activity (H3-K4 specific); histone methyltransferase complex; intracellular signal transduction; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR017956; IPR003889; IPR003888; IPR009071; IPR000637; IPR003616; IPR002219; IPR001214; IPR001594; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.43) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) KMT2C HALR KIAA1506 MLL3 Homo sapiens (Human) TR42046_c1_g1_i1 Q5SSH7 ZZEF1_MOUSE 2.00E-66 GO:0005509; GO:0008270 calcium ion binding; zinc ion binding IPR004939; IPR000859; IPR011992; IPR002048; IPR008979; IPR000433; Zinc finger ZZ-type and EF-hand domain-containing protein 1 Zzef1 Kiaa0399 Mus musculus (Mouse) TR42046_c1_g1_i4 O43149 ZZEF1_HUMAN 4.00E-72 GO:0005509; GO:0008270 calcium ion binding; zinc ion binding IPR004939; IPR000859; IPR011992; IPR002048; IPR008979; IPR000433; Zinc finger ZZ-type and EF-hand domain-containing protein 1 ZZEF1 KIAA0399 Homo sapiens (Human) TR42046_c1_g4_i1 Q5SSH7 ZZEF1_MOUSE 5.00E-88 GO:0005509; GO:0008270 calcium ion binding; zinc ion binding IPR004939; IPR000859; IPR011992; IPR002048; IPR008979; IPR000433; Zinc finger ZZ-type and EF-hand domain-containing protein 1 Zzef1 Kiaa0399 Mus musculus (Mouse) TR42047_c0_g1_i1 Q54QG7 GRLN_DICDI 2.00E-06 GO:0004930; GO:0016021 G-protein coupled receptor activity; integral to membrane IPR017978; Metabotropic glutamate receptor-like protein N grlN DDB_G0283839 Dictyostelium discoideum (Slime mold) TR42047_c1_g1_i1 Q9V6L0 KDM4B_DROME 1.00E-90 GO:0051864; GO:0032454; GO:0046872; GO:0045892; GO:0005634; GO:0006351 "histone demethylase activity (H3-K36 specific); histone demethylase activity (H3-K9 specific); metal ion binding; negative regulation of transcription, DNA-dependent; nucleus; transcription, DNA-dependent" IPR003347; IPR003349; Probable lysine-specific demethylase 4B (EC 1.14.11.-) (Probable JmjC domain-containing histone demethylation protein 3B) Kdm4B CG33182 Drosophila melanogaster (Fruit fly) TR42047_c2_g2_i1 Q8VCD7 KDM4C_MOUSE 1.00E-111 GO:0051213; GO:0032454; GO:0000790; GO:0008284; GO:0006357; GO:0006351; GO:0008270 "dioxygenase activity; histone demethylase activity (H3-K9 specific); nuclear chromatin; positive regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; zinc ion binding" IPR003347; IPR003349; IPR002999; IPR011011; IPR001965; IPR013083; Lysine-specific demethylase 4C (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) Kdm4c Jhdm3c Jmjd2c Kiaa0780 Mus musculus (Mouse) TR42047_c2_g2_i3 Q8VCD7 KDM4C_MOUSE 3.00E-111 GO:0051213; GO:0032454; GO:0000790; GO:0008284; GO:0006357; GO:0006351; GO:0008270 "dioxygenase activity; histone demethylase activity (H3-K9 specific); nuclear chromatin; positive regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; zinc ion binding" IPR003347; IPR003349; IPR002999; IPR011011; IPR001965; IPR013083; Lysine-specific demethylase 4C (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) Kdm4c Jhdm3c Jmjd2c Kiaa0780 Mus musculus (Mouse) TR42047_c6_g1_i1 Q9V6L0 KDM4B_DROME 2.00E-39 GO:0051864; GO:0032454; GO:0046872; GO:0045892; GO:0005634; GO:0006351 "histone demethylase activity (H3-K36 specific); histone demethylase activity (H3-K9 specific); metal ion binding; negative regulation of transcription, DNA-dependent; nucleus; transcription, DNA-dependent" IPR003347; IPR003349; Probable lysine-specific demethylase 4B (EC 1.14.11.-) (Probable JmjC domain-containing histone demethylation protein 3B) Kdm4B CG33182 Drosophila melanogaster (Fruit fly) TR42049_c1_g1_i1 Q5RK03 C2AIL_RAT 1.00E-06 IPR021859; CDKN2AIP N-terminal-like protein (CDKN2A-interacting protein N-terminal-like protein) Cdkn2aipnl Rattus norvegicus (Rat) TR42049_c3_g1_i1 Q93015 NAT6_HUMAN 5.00E-26 GO:0008080; GO:0005739 N-acetyltransferase activity; mitochondrion IPR016181; IPR000182; N-acetyltransferase 6 (EC 2.3.1.-) (Protein fusion-2) (Protein fus-2) NAT6 FUS2 Homo sapiens (Human) TR42049_c3_g2_i1 Q8BY02 NKRF_MOUSE 3.00E-33 GO:0003677; GO:0045892; GO:0005730; GO:0006351 "DNA binding; negative regulation of transcription, DNA-dependent; nucleolus; transcription, DNA-dependent" IPR014720; IPR000467; IPR001374; NF-kappa-B-repressing factor (NFkB-repressing factor) (Transcription factor NRF) Nkrf Nrf Mus musculus (Mouse) TR42049_c3_g4_i2 Q6AXB1 CF211_XENLA 1.00E-87 IPR002791; UPF0364 protein C6orf211 homolog Xenopus laevis (African clawed frog) TR42049_c3_g4_i3 Q58EM4 CF211_DANRE 4.00E-87 IPR002791; UPF0364 protein C6orf211 homolog zgc:110816 Danio rerio (Zebrafish) (Brachydanio rerio) TR42050_c1_g1_i1 P31396 HR3_DROME 1.00E-54 GO:0000977; GO:0004879; GO:0007552; GO:0016319; GO:0000122; GO:0005634; GO:0045944; GO:0040034; GO:0003707; GO:0004887; GO:0008270 "RNA polymerase II regulatory region sequence-specific DNA binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; metamorphosis; mushroom body development; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of development, heterochronic; steroid hormone receptor activity; thyroid hormone receptor activity; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001728; IPR001628; IPR013088; Probable nuclear hormone receptor HR3 (dHR3) (Nuclear receptor subfamily 1 group F member 4) Hr46 Hr3 NR1F4 CG11823 Drosophila melanogaster (Fruit fly) TR42050_c1_g1_i2 P51448 RORA_MOUSE 1.00E-42 GO:0003677; GO:0046068; GO:0021702; GO:0030522; GO:0004879; GO:0006809; GO:0005654; GO:0045944; GO:0043030; GO:0043565; GO:0003700; GO:0003707; GO:0008270 P54254; Q9QYH6 DNA binding; cGMP metabolic process; cerebellar Purkinje cell differentiation; intracellular receptor signaling pathway; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nitric oxide biosynthetic process; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; regulation of macrophage activation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; zinc ion binding IPR008946; IPR000536; IPR003079; IPR001723; IPR001628; IPR013088; Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (Retinoid-related orphan receptor-alpha) Rora Nr1f1 Rzra Mus musculus (Mouse) TR42050_c1_g2_i1 O16361 NH134_CAEEL 6.00E-10 GO:0005634; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR001628; IPR013088; Nuclear hormone receptor family member nhr-134 nhr-134 F44C8.2 Caenorhabditis elegans TR42050_c1_g2_i2 P41828 NHR23_CAEEL 9.00E-42 GO:0018996; GO:0005634; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "molting cycle, collagen and cuticulin-based cuticle; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Nuclear hormone receptor family member nhr-23 (Steroid hormone receptor family member chr-3) nhr-23 chr-3 C01H6.5 Caenorhabditis elegans TR42051_c1_g4_i1 Q6P301 YIF1B_XENTR 2.00E-100 GO:0016021 integral to membrane IPR005578; Protein YIF1B (YIP1-interacting factor homolog B) yif1b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42054_c1_g1_i1 Q968X7 PNO_CRYPV 4.00E-40 GO:0051539; GO:0010181; GO:0045333; GO:0022900; GO:0005506; GO:0005739; GO:0016491; GO:0050243; GO:0006090; GO:0030976 "4 iron, 4 sulfur cluster binding; FMN binding; cellular respiration; electron transport chain; iron ion binding; mitochondrion; oxidoreductase activity; pyruvate dehydrogenase (NADP+) activity; pyruvate metabolic process; thiamine pyrophosphate binding" IPR001450; IPR017896; IPR017900; IPR003097; IPR017927; IPR001094; IPR008254; IPR001709; IPR023173; IPR001433; IPR019456; IPR019752; IPR002880; IPR011895; IPR002869; IPR017938; IPR011766; IPR009014; Pyruvate dehydrogenase [NADP(+)] (EC 1.2.1.51) (CpPNO) (Pyruvate:NADP(+) oxidoreductase) PFOR Cryptosporidium parvum TR42054_c1_g1_i2 O08336 CYPE_BACSU 2.00E-58 GO:0010181; GO:0003958; GO:0070330; GO:0005737; GO:0020037; GO:0005506 FMN binding; NADPH-hemoprotein reductase activity; aromatase activity; cytoplasm; heme binding; iron ion binding IPR023206; IPR001128; IPR017972; IPR003097; IPR017927; IPR001094; IPR008254; IPR001709; IPR023173; IPR001433; IPR017938; Probable bifunctional P-450/NADPH-P450 reductase 2 [Includes: Cytochrome P450 102 (EC 1.14.14.1); NADPH--cytochrome P450 reductase (EC 1.6.2.4)] cypE CYP102A3 yrhJ BSU27160 Bacillus subtilis (strain 168) TR42054_c1_g1_i3 Q9SUM3 NCPR2_ARATH 8.00E-82 GO:0010181; GO:0003958; GO:0009507; GO:0005783; GO:0005789; GO:0005506; GO:0009698 FMN binding; NADPH-hemoprotein reductase activity; chloroplast; endoplasmic reticulum; endoplasmic reticulum membrane; iron ion binding; phenylpropanoid metabolic process IPR003097; IPR017927; IPR001094; IPR008254; IPR001709; IPR023173; IPR001433; IPR023208; IPR017938; NADPH--cytochrome P450 reductase 2 (EC 1.6.2.4) ATR2 AR2 At4g30210 F9N11.60 Arabidopsis thaliana (Mouse-ear cress) TR42054_c1_g3_i1 P16435 NCPR_HUMAN 0 GO:0010181; GO:0050661; GO:0003958; GO:0009437; GO:0090346; GO:0071372; GO:0071375; GO:0004128; GO:0070988; GO:0009055; GO:0005783; GO:0005789; GO:0019395; GO:0050660; GO:0009812; GO:0016787; GO:0018393; GO:0005506; GO:0047726; GO:0005739; GO:0043066; GO:0043154; GO:0060192; GO:0043602; GO:0046210; GO:0045542; GO:0032332; GO:0032770; GO:0045880; GO:0090031; GO:0003420; GO:0042493; GO:0007584 P00181; O00264 "FMN binding; NADP binding; NADPH-hemoprotein reductase activity; carnitine metabolic process; cellular organofluorine metabolic process; cellular response to follicle-stimulating hormone stimulus; cellular response to peptide hormone stimulus; cytochrome-b5 reductase activity, acting on NAD(P)H; demethylation; electron carrier activity; endoplasmic reticulum; endoplasmic reticulum membrane; fatty acid oxidation; flavin adenine dinucleotide binding; flavonoid metabolic process; hydrolase activity; internal peptidyl-lysine acetylation; iron ion binding; iron-cytochrome-c reductase activity; mitochondrion; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of lipase activity; nitrate catabolic process; nitric oxide catabolic process; positive regulation of cholesterol biosynthetic process; positive regulation of chondrocyte differentiation; positive regulation of monooxygenase activity; positive regulation of smoothened signaling pathway; positive regulation of steroid hormone biosynthetic process; regulation of growth plate cartilage chondrocyte proliferation; response to drug; response to nutrient" IPR003097; IPR017927; IPR001094; IPR008254; IPR001709; IPR023173; IPR001433; IPR023208; IPR017938; NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4) POR CYPOR Homo sapiens (Human) TR42054_c1_g3_i2 Q08C92 TYW1_DANRE 1.00E-21 GO:0051539; GO:0010181; GO:0005506; GO:0016491; GO:0008033 "4 iron, 4 sulfur cluster binding; FMN binding; iron ion binding; oxidoreductase activity; tRNA processing" IPR013785; IPR001094; IPR008254; IPR007197; IPR013917; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. tRNA wybutosine-synthesizing protein 1 homolog (Radical S-adenosyl methionine and flavodoxin domain-containing protein 1) (tRNA-yW-synthesizing protein) tyw1 rsafd1 zgc:153368 Danio rerio (Zebrafish) (Brachydanio rerio) TR42055_c0_g1_i1 A7Z035 EPN4_BOVIN 3.00E-82 GO:0005798; GO:0030136; GO:0006897; GO:0008289; GO:0016020; GO:0048471; GO:0005802 Golgi-associated vesicle; clathrin-coated vesicle; endocytosis; lipid binding; membrane; perinuclear region of cytoplasm; trans-Golgi network IPR008942; IPR013809; IPR001026; Clathrin interactor 1 (Epsin-4) CLINT1 EPN4 Bos taurus (Bovine) TR42055_c0_g1_i2 A7Z035 EPN4_BOVIN 9.00E-55 GO:0005798; GO:0030136; GO:0006897; GO:0008289; GO:0016020; GO:0048471; GO:0005802 Golgi-associated vesicle; clathrin-coated vesicle; endocytosis; lipid binding; membrane; perinuclear region of cytoplasm; trans-Golgi network IPR008942; IPR013809; IPR001026; Clathrin interactor 1 (Epsin-4) CLINT1 EPN4 Bos taurus (Bovine) TR42056_c1_g3_i1 Q6GMK8 GMPAA_DANRE 0 GO:0009298; GO:0005525; GO:0004475 GDP-mannose biosynthetic process; GTP binding; mannose-1-phosphate guanylyltransferase activity IPR001451; IPR018357; IPR005835; Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1. Mannose-1-phosphate guanyltransferase alpha-A (EC 2.7.7.13) (GDP-mannose pyrophosphorylase A-A) (GTP-mannose-1-phosphate guanylyltransferase subunit alpha-A) gmppaa zgc:91853 Danio rerio (Zebrafish) (Brachydanio rerio) TR42056_c1_g3_i2 Q5XIC1 GMPPA_RAT 0 GO:0009298; GO:0005525; GO:0005829; GO:0004475 GDP-mannose biosynthetic process; GTP binding; cytosol; mannose-1-phosphate guanylyltransferase activity IPR001451; IPR018357; IPR005835; Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1. Mannose-1-phosphate guanyltransferase alpha (EC 2.7.7.13) (GDP-mannose pyrophosphorylase A) (GTP-mannose-1-phosphate guanylyltransferase alpha) Gmppa Rattus norvegicus (Rat) TR42056_c1_g3_i4 P37820 MPG1_SULAC 6.00E-19 GO:0005525; GO:0009058; GO:0004475 GTP binding; biosynthetic process; mannose-1-phosphate guanylyltransferase activity IPR001451; IPR005835; Putative mannose-1-phosphate guanyltransferase (EC 2.7.7.13) (ATP-mannose-1-phosphate guanylyltransferase) (GDP-mannose pyrophosphorylase) (NDP-hexose pyrophosphorylase) mpg1 Saci_0196 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) TR42056_c1_g3_i5 B9DRS6 GLGC_STRU0 6.00E-13 GO:0005524; GO:0008878; GO:0005978 ATP binding; glucose-1-phosphate adenylyltransferase activity; glycogen biosynthetic process IPR005836; IPR011831; IPR023049; IPR001451; IPR005835; IPR011004; Glycan biosynthesis; glycogen biosynthesis. Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) (ADP-glucose pyrophosphorylase) (ADPGlc PPase) (ADP-glucose synthase) glgC SUB0662 Streptococcus uberis (strain ATCC BAA-854 / 0140J) TR42056_c1_g3_i6 Q6GMK8 GMPAA_DANRE 0 GO:0009298; GO:0005525; GO:0004475 GDP-mannose biosynthetic process; GTP binding; mannose-1-phosphate guanylyltransferase activity IPR001451; IPR018357; IPR005835; Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1. Mannose-1-phosphate guanyltransferase alpha-A (EC 2.7.7.13) (GDP-mannose pyrophosphorylase A-A) (GTP-mannose-1-phosphate guanylyltransferase subunit alpha-A) gmppaa zgc:91853 Danio rerio (Zebrafish) (Brachydanio rerio) TR42057_c0_g1_i3 P53918 ESBP6_YEAST 1.00E-06 GO:0005789; GO:0016021; GO:0016020; GO:0005739; GO:0015293; GO:0005215 P25376; P08456; P41543; P40975; P87284; P32368; P39986 endoplasmic reticulum membrane; integral to membrane; membrane; mitochondrion; symporter activity; transporter activity IPR011701; IPR016196; Uncharacterized transporter ESBP6 ESBP6 MCH3 YNL125C N1223 N1882 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42057_c0_g2_i1 Q6P2X9 MOT12_XENTR 2.00E-08 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42057_c0_g2_i2 O35308 MOT3_MOUSE 5.00E-18 GO:0016021; GO:0005886; GO:0015355; GO:0015293 integral to membrane; plasma membrane; secondary active monocarboxylate transmembrane transporter activity; symporter activity IPR011701; IPR020846; IPR016196; IPR004743; Monocarboxylate transporter 3 (MCT 3) (Proton-coupled monocarboxylate transporter 3) (Solute carrier family 16 member 8) Slc16a8 Mct3 Mus musculus (Mouse) TR42057_c0_g2_i3 Q8TF71 MOT10_HUMAN 1.00E-16 GO:0015801; GO:0016323; GO:0016021; GO:0055085 aromatic amino acid transport; basolateral plasma membrane; integral to membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 10 (MCT 10) (Aromatic amino acid transporter 1) (Solute carrier family 16 member 10) (T-type amino acid transporter 1) SLC16A10 MCT10 TAT1 Homo sapiens (Human) TR42057_c0_g4_i2 Q7RTX9 MOT14_HUMAN 4.00E-21 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR42057_c0_g4_i3 Q7TM99 MOT9_MOUSE 1.00E-19 GO:0016021; GO:0005886; GO:0015293; GO:0046415 integral to membrane; plasma membrane; symporter activity; urate metabolic process IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) Slc16a9 Mct9 Mus musculus (Mouse) TR42059_c4_g3_i2 O94813 SLIT2_HUMAN 1.00E-09 GO:0005095; GO:0035385; GO:0061364; GO:0048846; GO:0048754; GO:0005509; GO:0002042; GO:0009986; GO:0016337; GO:0071504; GO:0032870; GO:0045499; GO:0021836; GO:0021972; GO:0005737; GO:0033563; GO:0005615; GO:0008201; GO:0001701; GO:0050929; GO:0043237; GO:0060763; GO:0001656; GO:0008045; GO:0030837; GO:0030308; GO:0008285; GO:0090288; GO:0070100; GO:0010596; GO:0010629; GO:0010593; GO:0090027; GO:0071676; GO:0090024; GO:0001933; GO:0090260; GO:0051058; GO:0071672; GO:0043116; GO:0005886; GO:0043065; GO:0050772; GO:0042803; GO:0051414; GO:0031290; GO:0001657 Itself GTPase inhibitor activity; Roundabout signaling pathway; apoptotic process involved in luteolysis; axon extension involved in axon guidance; branching morphogenesis of an epithelial tube; calcium ion binding; cell migration involved in sprouting angiogenesis; cell surface; cell-cell adhesion; cellular response to heparin; cellular response to hormone stimulus; chemorepellent activity; chemorepulsion involved in postnatal olfactory bulb interneuron migration; corticospinal neuron axon guidance through spinal cord; cytoplasm; dorsal/ventral axon guidance; extracellular space; heparin binding; in utero embryonic development; induction of negative chemotaxis; laminin-1 binding; mammary duct terminal end bud growth; metanephros development; motor neuron axon guidance; negative regulation of actin filament polymerization; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cellular response to growth factor stimulus; negative regulation of chemokine-mediated signaling pathway; negative regulation of endothelial cell migration; negative regulation of gene expression; negative regulation of lamellipodium assembly; negative regulation of monocyte chemotaxis; negative regulation of mononuclear cell migration; negative regulation of neutrophil chemotaxis; negative regulation of protein phosphorylation; negative regulation of retinal ganglion cell axon guidance; negative regulation of small GTPase mediated signal transduction; negative regulation of smooth muscle cell chemotaxis; negative regulation of vascular permeability; plasma membrane; positive regulation of apoptotic process; positive regulation of axonogenesis; protein homodimerization activity; response to cortisol stimulus; retinal ganglion cell axon guidance; ureteric bud development IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product] SLIT2 SLIL3 Homo sapiens (Human) TR42059_c5_g1_i1 Q9BXB1 LGR4_HUMAN 9.00E-06 GO:0004930; GO:0030282; GO:0046849; GO:0061290; GO:0072202; GO:0050673; GO:0045087; GO:0005887; GO:0030539; GO:0072224; GO:0072282; GO:0050710; GO:0034122; GO:0045892; GO:0001649; GO:0090190; GO:0090263; GO:0045893; GO:0007283 "G-protein coupled receptor activity; bone mineralization; bone remodeling; canonical Wnt receptor signaling pathway involved in metanephric kidney development; cell differentiation involved in metanephros development; epithelial cell proliferation; innate immune response; integral to plasma membrane; male genitalia development; metanephric glomerulus development; metanephric nephron tubule morphogenesis; negative regulation of cytokine secretion; negative regulation of toll-like receptor signaling pathway; negative regulation of transcription, DNA-dependent; osteoblast differentiation; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of transcription, DNA-dependent; spermatogenesis" IPR000276; IPR017452; IPR002131; IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48) LGR4 GPR48 Homo sapiens (Human) TR42059_c5_g1_i3 Q96PB8 LRC3B_HUMAN 9.00E-08 GO:0016021 integral to membrane IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing protein 3B (Leucine-rich repeat protein LRP15) LRRC3B LRP15 UNQ195/PRO221 Homo sapiens (Human) TR42060_c3_g1_i1 P07872 ACOX1_RAT 0 GO:0003995; GO:0033540; GO:0005504; GO:0050660; GO:0006091; GO:0016401; GO:0005777; GO:0006693 acyl-CoA dehydrogenase activity; fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid binding; flavin adenine dinucleotide binding; generation of precursor metabolites and energy; palmitoyl-CoA oxidase activity; peroxisome; prostaglandin metabolic process IPR006091; IPR012258; IPR002655; IPR009075; IPR013786; IPR009100; Lipid metabolism; peroxisomal fatty acid beta-oxidation. "Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain]" Acox1 Acox Rattus norvegicus (Rat) TR42060_c3_g1_i2 P07872 ACOX1_RAT 0 GO:0003995; GO:0033540; GO:0005504; GO:0050660; GO:0006091; GO:0016401; GO:0005777; GO:0006693 acyl-CoA dehydrogenase activity; fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid binding; flavin adenine dinucleotide binding; generation of precursor metabolites and energy; palmitoyl-CoA oxidase activity; peroxisome; prostaglandin metabolic process IPR006091; IPR012258; IPR002655; IPR009075; IPR013786; IPR009100; Lipid metabolism; peroxisomal fatty acid beta-oxidation. "Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain]" Acox1 Acox Rattus norvegicus (Rat) TR42060_c3_g1_i4 Q3SZP5 ACOX1_BOVIN 0 GO:0003995; GO:0003997; GO:0033540; GO:0019395; GO:0050660; GO:0006091; GO:0005777; GO:0006693 acyl-CoA dehydrogenase activity; acyl-CoA oxidase activity; fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid oxidation; flavin adenine dinucleotide binding; generation of precursor metabolites and energy; peroxisome; prostaglandin metabolic process IPR006091; IPR012258; IPR002655; IPR009075; IPR013786; IPR009100; Lipid metabolism; peroxisomal fatty acid beta-oxidation. Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) ACOX1 Bos taurus (Bovine) TR42061_c0_g3_i1 Q5RDY7 GBB5_PONAB 9.00E-107 GO:0004871 signal transducer activity IPR020472; IPR001632; IPR016346; IPR015943; IPR001680; IPR019775; IPR017986; Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5) GNB5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42061_c0_g3_i2 A2CEH0 POC1B_DANRE 2.00E-17 GO:0042384; GO:0060287; GO:0003014 cilium assembly; epithelial cilium movement involved in determination of left/right asymmetry; renal system process IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; POC1 centriolar protein homolog B (WD repeat domain 51B) poc1b tuwd12 wdr51b si:dkey-164B12.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR42061_c0_g3_i3 Q5RDY7 GBB5_PONAB 8.00E-171 GO:0004871 signal transducer activity IPR020472; IPR001632; IPR016346; IPR015943; IPR001680; IPR019775; IPR017986; Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5) GNB5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42061_c0_g3_i4 Q6C709 PRP46_YARLI 9.00E-21 GO:0008380; GO:0007049; GO:0005737; GO:0006397; GO:0005681 RNA splicing; cell cycle; cytoplasm; mRNA processing; spliceosomal complex IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Pre-mRNA-splicing factor PRP46 (Pre-mRNA-processing protein 46) PRP46 YALI0E04697g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR42062_c0_g1_i2 Q6ZR37 PKHG7_HUMAN 2.00E-27 GO:0005089; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; phospholipid binding; regulation of Rho protein signal transduction IPR000219; IPR011993; IPR001849; Pleckstrin homology domain-containing family G member 7 (PH domain-containing family G member 7) PLEKHG7 Homo sapiens (Human) TR42063_c3_g3_i1 C3YWU0 FUCO_BRAFL 0 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR42063_c3_g3_i5 C3YWU0 FUCO_BRAFL 0 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR42063_c3_g3_i6 Q2KIM0 FUCO_BOVIN 1.00E-179 GO:0004560; GO:0042806; GO:0006004; GO:0005764 alpha-L-fucosidase activity; fucose binding; fucose metabolic process; lysosome IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) FUCA1 Bos taurus (Bovine) TR42064_c1_g1_i1 Q9D711 PIR_MOUSE 5.00E-52 GO:0005737; GO:0046872; GO:0030224; GO:0005634; GO:0008127; GO:0006355; GO:0003712; GO:0006351 "cytoplasm; metal ion binding; monocyte differentiation; nucleus; quercetin 2,3-dioxygenase activity; regulation of transcription, DNA-dependent; transcription cofactor activity; transcription, DNA-dependent" IPR012093; IPR008778; IPR003829; IPR014710; IPR011051; Flavonoid metabolism; quercetin degradation. "Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase)" Pir Mus musculus (Mouse) TR42064_c1_g1_i2 Q9HZ00 Y3240_PSEAE 4.00E-56 GO:0046872; GO:0008127 "metal ion binding; quercetin 2,3-dioxygenase activity" IPR012093; IPR008778; IPR003829; IPR014710; IPR011051; Flavonoid metabolism; quercetin degradation. "Putative quercetin 2,3-dioxygenase PA3240 (Putative quercetinase) (EC 1.13.11.24) (Pirin-like protein PA3240)" PA3240 Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) TR42064_c1_g1_i4 Q9KKY1 Y3769_VIBCH 6.00E-44 GO:0046872; GO:0008127 "metal ion binding; quercetin 2,3-dioxygenase activity" IPR012093; IPR008778; IPR003829; IPR014710; IPR011051; Flavonoid metabolism; quercetin degradation. "Putative quercetin 2,3-dioxygenase VC_A0969 (Putative quercetinase) (EC 1.13.11.24) (Pirin-like protein VC_A0969)" VC_A0969 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) TR42064_c1_g1_i6 P65725 Y187_MYCBO 1.00E-12 GO:0046872; GO:0008127 "metal ion binding; quercetin 2,3-dioxygenase activity" IPR012093; IPR003829; IPR014710; IPR011051; Flavonoid metabolism; quercetin degradation. "Putative quercetin 2,3-dioxygenase Mb0187c (Putative quercetinase) (EC 1.13.11.24) (Pirin-like protein Mb0187c)" Mb0187c Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) TR42064_c1_g1_i7 Q9D711 PIR_MOUSE 1.00E-117 GO:0005737; GO:0046872; GO:0030224; GO:0005634; GO:0008127; GO:0006355; GO:0003712; GO:0006351 "cytoplasm; metal ion binding; monocyte differentiation; nucleus; quercetin 2,3-dioxygenase activity; regulation of transcription, DNA-dependent; transcription cofactor activity; transcription, DNA-dependent" IPR012093; IPR008778; IPR003829; IPR014710; IPR011051; Flavonoid metabolism; quercetin degradation. "Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase)" Pir Mus musculus (Mouse) TR42065_c1_g1_i1 Q00229 NU2M_MYTED 7.00E-69 GO:0008137; GO:0016021; GO:0005743; GO:0070469 NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial inner membrane; respiratory chain IPR001750; NADH-ubiquinone oxidoreductase chain 2 (EC 1.6.5.3) (NADH dehydrogenase subunit 2) ND2 Mytilus edulis (Blue mussel) TR42065_c2_g1_i1 Q00231 NU4M_MYTED 3.00E-163 GO:0042773; GO:0008137; GO:0016021; GO:0031966; GO:0070469 ATP synthesis coupled electron transport; NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial membrane; respiratory chain IPR001750; IPR003918; NADH-ubiquinone oxidoreductase chain 4 (EC 1.6.5.3) (NADH dehydrogenase subunit 4) ND4 Mytilus edulis (Blue mussel) TR42065_c2_g3_i1 P41775 COX3_MYTED 4.00E-68 GO:0019646; GO:0004129; GO:0016021; GO:0005743 aerobic electron transport chain; cytochrome-c oxidase activity; integral to membrane; mitochondrial inner membrane IPR024791; IPR000298; IPR013833; Cytochrome c oxidase subunit 3 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide III) COIII Mytilus edulis (Blue mussel) TR42065_c2_g5_i1 Q00229 NU2M_MYTED 3.00E-101 GO:0008137; GO:0016021; GO:0005743; GO:0070469 NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial inner membrane; respiratory chain IPR001750; NADH-ubiquinone oxidoreductase chain 2 (EC 1.6.5.3) (NADH dehydrogenase subunit 2) ND2 Mytilus edulis (Blue mussel) TR42066_c1_g1_i1 E7F9T0 MICA1_DANRE 2.00E-27 GO:0071949; GO:0003779; GO:0030042; GO:0005737; GO:0005856; GO:0016709; GO:0019417; GO:0008270 "FAD binding; actin binding; actin filament depolymerization; cytoplasm; cytoskeleton; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; sulfur oxidation; zinc ion binding" IPR001715; IPR022735; IPR002938; IPR001781; Protein-methionine sulfoxide oxidase mical1 (EC 1.14.13.-) (Molecule interacting with CasL protein 1) (MICAL-1) mical1 Danio rerio (Zebrafish) (Brachydanio rerio) TR42069_c0_g1_i1 Q9XZC8 SEM2A_SCHGR 1.00E-66 GO:0030154; GO:0005576; GO:0016020; GO:0007399; GO:0004872 cell differentiation; extracellular region; membrane; nervous system development; receptor activity IPR007110; IPR013783; IPR003599; IPR016201; IPR001627; IPR027231; IPR015943; Semaphorin-2A (Sema-2A) (Sema II) SEMA-2A Schistocerca gregaria (Desert locust) TR42069_c0_g1_i2 Q24323 SEM2A_DROME 1.00E-69 GO:0007411; GO:0070983; GO:0042756; GO:0005576; GO:0007629; GO:0016020; GO:0004872; GO:0016201; GO:0007632 axon guidance; dendrite guidance; drinking behavior; extracellular region; flight behavior; membrane; receptor activity; synaptic target inhibition; visual behavior IPR007110; IPR013783; IPR003599; IPR016201; IPR001627; IPR027231; IPR015943; Semaphorin-2A (Semaphorin-II) (Sema II) Sema-2a dSema-II CG4700 Drosophila melanogaster (Fruit fly) TR42069_c0_g1_i3 Q9XZC8 SEM2A_SCHGR 2.00E-66 GO:0030154; GO:0005576; GO:0016020; GO:0007399; GO:0004872 cell differentiation; extracellular region; membrane; nervous system development; receptor activity IPR007110; IPR013783; IPR003599; IPR016201; IPR001627; IPR027231; IPR015943; Semaphorin-2A (Sema-2A) (Sema II) SEMA-2A Schistocerca gregaria (Desert locust) TR42069_c0_g1_i4 Q24323 SEM2A_DROME 3.00E-69 GO:0007411; GO:0070983; GO:0042756; GO:0005576; GO:0007629; GO:0016020; GO:0004872; GO:0016201; GO:0007632 axon guidance; dendrite guidance; drinking behavior; extracellular region; flight behavior; membrane; receptor activity; synaptic target inhibition; visual behavior IPR007110; IPR013783; IPR003599; IPR016201; IPR001627; IPR027231; IPR015943; Semaphorin-2A (Semaphorin-II) (Sema II) Sema-2a dSema-II CG4700 Drosophila melanogaster (Fruit fly) TR42069_c0_g1_i5 Q17330 SEM1A_CAEEL 7.00E-50 GO:0030154; GO:0016021; GO:0007399; GO:0004872 cell differentiation; integral to membrane; nervous system development; receptor activity IPR016201; IPR002165; IPR001627; IPR027231; IPR015943; Semaphorin-1A (CeSema) smp-1 sema-1a Y54E5B.1 Caenorhabditis elegans TR42069_c0_g1_i6 Q24323 SEM2A_DROME 5.00E-45 GO:0007411; GO:0070983; GO:0042756; GO:0005576; GO:0007629; GO:0016020; GO:0004872; GO:0016201; GO:0007632 axon guidance; dendrite guidance; drinking behavior; extracellular region; flight behavior; membrane; receptor activity; synaptic target inhibition; visual behavior IPR007110; IPR013783; IPR003599; IPR016201; IPR001627; IPR027231; IPR015943; Semaphorin-2A (Semaphorin-II) (Sema II) Sema-2a dSema-II CG4700 Drosophila melanogaster (Fruit fly) TR42071_c1_g1_i1 P27641 XRCC5_MOUSE 7.00E-69 GO:0051575; GO:0005524; GO:0004003; GO:0006310; GO:0043564; GO:0008283; GO:0005737; GO:0003684; GO:0006303; GO:0003691; GO:0060218; GO:0045892; GO:0070419; GO:0000784; GO:0005730; GO:0050769; GO:0000723; GO:0044212; GO:0006351 "5'-deoxyribose-5-phosphate lyase activity; ATP binding; ATP-dependent DNA helicase activity; DNA recombination; Ku70:Ku80 complex; cell proliferation; cytoplasm; damaged DNA binding; double-strand break repair via nonhomologous end joining; double-stranded telomeric DNA binding; hematopoietic stem cell differentiation; negative regulation of transcription, DNA-dependent; nonhomologous end joining complex; nuclear chromosome, telomeric region; nucleolus; positive regulation of neurogenesis; telomere maintenance; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR006164; IPR024193; IPR005160; IPR005161; IPR014893; IPR016194; IPR002035; X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku autoantigen protein p86 homolog) (Ku80) (Nuclear factor IV) Xrcc5 G22p2 Mus musculus (Mouse) TR42071_c1_g1_i3 P27641 XRCC5_MOUSE 7.00E-69 GO:0051575; GO:0005524; GO:0004003; GO:0006310; GO:0043564; GO:0008283; GO:0005737; GO:0003684; GO:0006303; GO:0003691; GO:0060218; GO:0045892; GO:0070419; GO:0000784; GO:0005730; GO:0050769; GO:0000723; GO:0044212; GO:0006351 "5'-deoxyribose-5-phosphate lyase activity; ATP binding; ATP-dependent DNA helicase activity; DNA recombination; Ku70:Ku80 complex; cell proliferation; cytoplasm; damaged DNA binding; double-strand break repair via nonhomologous end joining; double-stranded telomeric DNA binding; hematopoietic stem cell differentiation; negative regulation of transcription, DNA-dependent; nonhomologous end joining complex; nuclear chromosome, telomeric region; nucleolus; positive regulation of neurogenesis; telomere maintenance; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR006164; IPR024193; IPR005160; IPR005161; IPR014893; IPR016194; IPR002035; X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku autoantigen protein p86 homolog) (Ku80) (Nuclear factor IV) Xrcc5 G22p2 Mus musculus (Mouse) TR42073_c1_g2_i3 Q9BT09 CNPY3_HUMAN 7.00E-58 GO:0005788; GO:0045087; GO:0002224 endoplasmic reticulum lumen; innate immune response; toll-like receptor signaling pathway IPR021852; Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat-domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat-containing gene 5 protein) CNPY3 CTG4A ERDA5 PRAT4A TNRC5 HSPC084 UNQ1934/PRO4409 Homo sapiens (Human) TR42074_c1_g3_i4 P51909 APOD_CAVPO 8.00E-07 GO:0007568; GO:0007420; GO:0015485; GO:0022626; GO:0030425; GO:0005783; GO:0005615; GO:0006006; GO:0006629; GO:2000405; GO:1900016; GO:0051895; GO:0060588; GO:0071638; GO:0010642; GO:0042308; GO:0048662; GO:2000098; GO:0043025; GO:0048471; GO:0014012; GO:0042493; GO:0000302; GO:0042246; GO:0005215 aging; brain development; cholesterol binding; cytosolic ribosome; dendrite; endoplasmic reticulum; extracellular space; glucose metabolic process; lipid metabolic process; negative regulation of T cell migration; negative regulation of cytokine production involved in inflammatory response; negative regulation of focal adhesion assembly; negative regulation of lipoprotein lipid oxidation; negative regulation of monocyte chemotactic protein-1 production; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein import into nucleus; negative regulation of smooth muscle cell proliferation; negative regulation of smooth muscle cell-matrix adhesion; neuronal cell body; perinuclear region of cytoplasm; peripheral nervous system axon regeneration; response to drug; response to reactive oxygen species; tissue regeneration; transporter activity IPR026222; IPR002969; IPR012674; IPR011038; IPR022271; IPR022272; IPR000566; Apolipoprotein D (Apo-D) (ApoD) APOD Cavia porcellus (Guinea pig) TR42075_c1_g1_i1 A0JP85 CNOT1_XENTR 0 GO:0030014; GO:0000932; GO:0030331; GO:0031047; GO:0033147; GO:0048387; GO:0000122; GO:0005634; GO:0010606; GO:1900153; GO:0060213; GO:0006417; GO:0042974; GO:0006351 "CCR4-NOT complex; cytoplasmic mRNA processing body; estrogen receptor binding; gene silencing by RNA; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of retinoic acid receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of cytoplasmic mRNA processing body assembly; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; regulation of translation; retinoic acid receptor binding; transcription, DNA-dependent" IPR007196; IPR024557; CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) cnot1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42075_c1_g1_i2 A0JP85 CNOT1_XENTR 0 GO:0030014; GO:0000932; GO:0030331; GO:0031047; GO:0033147; GO:0048387; GO:0000122; GO:0005634; GO:0010606; GO:1900153; GO:0060213; GO:0006417; GO:0042974; GO:0006351 "CCR4-NOT complex; cytoplasmic mRNA processing body; estrogen receptor binding; gene silencing by RNA; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of retinoic acid receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of cytoplasmic mRNA processing body assembly; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; regulation of translation; retinoic acid receptor binding; transcription, DNA-dependent" IPR007196; IPR024557; CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) cnot1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42076_c1_g2_i3 O60229 KALRN_HUMAN 1.00E-135 GO:0005524; GO:0005089; GO:0015629; GO:0097190; GO:0005829; GO:0005085; GO:0046872; GO:0007399; GO:0048011; GO:0005543; GO:0043065; GO:0004674; GO:0035023; GO:0051056; GO:0007264; GO:0016192 ATP binding; Rho guanyl-nucleotide exchange factor activity; actin cytoskeleton; apoptotic signaling pathway; cytosol; guanyl-nucleotide exchange factor activity; metal ion binding; nervous system development; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of apoptotic process; protein serine/threonine kinase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; vesicle-mediated transport IPR001251; IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR017441; IPR002290; IPR008271; IPR001452; IPR018159; IPR002017; Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain) KALRN DUET DUO HAPIP TRAD Homo sapiens (Human) TR42076_c1_g2_i4 O60229 KALRN_HUMAN 1.00E-135 GO:0005524; GO:0005089; GO:0015629; GO:0097190; GO:0005829; GO:0005085; GO:0046872; GO:0007399; GO:0048011; GO:0005543; GO:0043065; GO:0004674; GO:0035023; GO:0051056; GO:0007264; GO:0016192 ATP binding; Rho guanyl-nucleotide exchange factor activity; actin cytoskeleton; apoptotic signaling pathway; cytosol; guanyl-nucleotide exchange factor activity; metal ion binding; nervous system development; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of apoptotic process; protein serine/threonine kinase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; vesicle-mediated transport IPR001251; IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR017441; IPR002290; IPR008271; IPR001452; IPR018159; IPR002017; Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain) KALRN DUET DUO HAPIP TRAD Homo sapiens (Human) TR42076_c1_g2_i5 O43293 DAPK3_HUMAN 3.00E-55 GO:0005524; GO:0016605; GO:0006915; GO:0071346; GO:0016568; GO:0000775; GO:0000910; GO:0005737; GO:0007243; GO:0005815; GO:0017148; GO:0030182; GO:0005634; GO:0090263; GO:2001241; GO:0046777; GO:0042803; GO:0004674; GO:2000249; GO:0042981; GO:0010506; GO:2000145; GO:0007088; GO:0006940; GO:0006355; GO:0006351 Itself "ATP binding; PML body; apoptotic process; cellular response to interferon-gamma; chromatin modification; chromosome, centromeric region; cytokinesis; cytoplasm; intracellular protein kinase cascade; microtubule organizing center; negative regulation of translation; neuron differentiation; nucleus; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; protein autophosphorylation; protein homodimerization activity; protein serine/threonine kinase activity; regulation of actin cytoskeleton reorganization; regulation of apoptotic process; regulation of autophagy; regulation of cell motility; regulation of mitosis; regulation of smooth muscle contraction; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011009; IPR020675; IPR000719; IPR017441; IPR002290; IPR008271; Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase) DAPK3 ZIPK Homo sapiens (Human) TR42076_c1_g2_i6 O75962 TRIO_HUMAN 2.00E-72 GO:0005524; GO:0005089; GO:0097190; GO:0007411; GO:0005829; GO:0005085; GO:0048011; GO:0005543; GO:0043065; GO:0004674; GO:0035023; GO:0051056; GO:0007264; GO:0007185 Q9NRI5 ATP binding; Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; axon guidance; cytosol; guanyl-nucleotide exchange factor activity; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of apoptotic process; protein serine/threonine kinase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine phosphatase signaling pathway IPR001251; IPR000219; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR002290; IPR008271; IPR001452; IPR018159; IPR002017; Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) TRIO Homo sapiens (Human) TR42078_c1_g2_i1 Q8NBH2 KY_HUMAN 1.00E-43 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) KY Homo sapiens (Human) TR42078_c1_g2_i4 Q8NBH2 KY_HUMAN 1.00E-46 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) KY Homo sapiens (Human) TR42078_c1_g2_i6 O14302 CYK3_SCHPO 4.00E-09 GO:0005826; GO:0030428; GO:0051286; GO:0000281 actomyosin contractile ring; cell septum; cell tip; mitotic cytokinesis IPR001452; IPR002931; cytokinesis protein 3 cyk3 SPAC9G1.06c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR4208_c0_g1_i1 Q6V0I7 FAT4_HUMAN 9.00E-17 GO:0005509; GO:0007156; GO:0016021; GO:0005886 Q9H2K2 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) TR42080_c0_g3_i10 Q62318 TIF1B_MOUSE 8.00E-06 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0003713; GO:0003714; GO:0006351; GO:0004842; GO:0008270 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; transcription coactivator activity; transcription corepressor activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-A-interacting protein) (KRIP-1) (Tripartite motif-containing protein 28) Trim28 Krip1 Tif1b Mus musculus (Mouse) TR42080_c0_g3_i5 O08629 TIF1B_RAT 5.00E-06 GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0005719; GO:0005720; GO:0005654; GO:0005634; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006351; GO:0004842; GO:0008270 "DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; nucleus; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (Nuclear corepressor KAP-1) (Tripartite motif-containing protein 28) Trim28 Kap1 Tif1b Rattus norvegicus (Rat) TR42082_c5_g1_i3 Q86UF1 TSN33_HUMAN 4.00E-17 GO:0016021 integral to membrane IPR000301; IPR018499; IPR008952; Tetraspanin-33 (Tspan-33) (Penumbra) (hPen) (Proerythroblast new membrane) TSPAN33 PEN Homo sapiens (Human) TR42082_c5_g1_i9 Q86UF1 TSN33_HUMAN 2.00E-16 GO:0016021 integral to membrane IPR000301; IPR018499; IPR008952; Tetraspanin-33 (Tspan-33) (Penumbra) (hPen) (Proerythroblast new membrane) TSPAN33 PEN Homo sapiens (Human) TR42083_c0_g3_i2 Q4R4J0 GDIR1_MACFA 2.00E-57 GO:0005096; GO:0005094; GO:0005737; GO:0043547 GTPase activator activity; Rho GDP-dissociation inhibitor activity; cytoplasm; positive regulation of GTPase activity IPR014756; IPR000406; IPR024792; Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) ARHGDIA QtrA-11619 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR42086_c1_g1_i1 Q8N6T3 ARFG1_HUMAN 1.00E-63 GO:0008060; GO:0048205; GO:0005096; GO:0030660; GO:0006987; GO:0044267; GO:0005829; GO:0005783; GO:0031965; GO:0005886; GO:0015031; GO:0032312; GO:0006890; GO:0045202; GO:0008270 Q5S007 "ARF GTPase activator activity; COPI coating of Golgi vesicle; GTPase activator activity; Golgi-associated vesicle membrane; activation of signaling protein activity involved in unfolded protein response; cellular protein metabolic process; cytosol; endoplasmic reticulum; nuclear membrane; plasma membrane; protein transport; regulation of ARF GTPase activity; retrograde vesicle-mediated transport, Golgi to ER; synapse; zinc ion binding" IPR001164; ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) ARFGAP1 ARF1GAP Homo sapiens (Human) TR42086_c1_g2_i1 O82171 AGD10_ARATH 7.00E-14 GO:0008060; GO:0005794; GO:0009793; GO:0009555; GO:0043547; GO:0032312; GO:0008270 ARF GTPase activator activity; Golgi apparatus; embryo development ending in seed dormancy; pollen development; positive regulation of GTPase activity; regulation of ARF GTPase activity; zinc ion binding IPR001164; ADP-ribosylation factor GTPase-activating protein AGD10 (ARF GAP AGD10) (Protein ARF-GAP DOMAIN 10) (AtAGD10) (Protein MATERNAL EFFECT EMBRYO ARREST 28) (Protein ROOT AND POLLEN ARFGAP) AGD10 MEE28 RPA At2g35210 T4C15.12 Arabidopsis thaliana (Mouse-ear cress) TR42087_c7_g1_i1 Q9Y535 RPC8_HUMAN 2.00E-98 GO:0003677; GO:0005666; GO:0003899; GO:0005813; GO:0005829; GO:0051607; GO:0045087; GO:0032481; GO:0006386; GO:0006385 DNA binding; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase activity; centrosome; cytosol; defense response to virus; innate immune response; positive regulation of type I interferon production; termination of RNA polymerase III transcription; transcription elongation from RNA polymerase III promoter IPR012340; IPR013238; IPR005576; IPR004519; DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (RNA polymerase III subunit 22.9 kDa subunit) (RPC22.9) POLR3H KIAA1665 RPC8 Homo sapiens (Human) TR42089_c0_g2_i2 P49756 RBM25_HUMAN 2.00E-62 GO:0008380; GO:0005737; GO:0097194; GO:0003729; GO:0006397; GO:0016607; GO:0000166; GO:0000381 "RNA splicing; cytoplasm; execution phase of apoptosis; mRNA binding; mRNA processing; nuclear speck; nucleotide binding; regulation of alternative mRNA splicing, via spliceosome" IPR012677; IPR002483; IPR000504; RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) RBM25 RNPC7 Homo sapiens (Human) TR42089_c0_g2_i3 P49756 RBM25_HUMAN 1.00E-62 GO:0008380; GO:0005737; GO:0097194; GO:0003729; GO:0006397; GO:0016607; GO:0000166; GO:0000381 "RNA splicing; cytoplasm; execution phase of apoptosis; mRNA binding; mRNA processing; nuclear speck; nucleotide binding; regulation of alternative mRNA splicing, via spliceosome" IPR012677; IPR002483; IPR000504; RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) RBM25 RNPC7 Homo sapiens (Human) TR42089_c0_g3_i1 Q8C7E9 CSTFT_MOUSE 3.00E-07 GO:0003723; GO:0006378; GO:0000166; GO:0005634 RNA binding; mRNA polyadenylation; nucleotide binding; nucleus IPR025742; IPR026896; IPR012677; IPR000504; Cleavage stimulation factor subunit 2 tau variant (CF-1 64 kDa subunit tau variant) (Cleavage stimulation factor 64 kDa subunit tau variant) (CSTF 64 kDa subunit tau variant) (TauCstF-64) Cstf2t Kiaa0689 Mus musculus (Mouse) TR42093_c0_g1_i1 Q16531 DDB1_HUMAN 0 GO:0031464; GO:0031465; GO:0016055; GO:0005737; GO:0003684; GO:0019048; GO:0005654; GO:0000718; GO:0043161; GO:0042787; GO:1901990 Q9H9F9; Q13619; Q13620; Q92466; Q9NZJ0; O75530; Q9ULG1; P11207; P42224; Q04725; Q9Y4B6; P18045 "Cul4A-RING ubiquitin ligase complex; Cul4B-RING ubiquitin ligase complex; Wnt receptor signaling pathway; cytoplasm; damaged DNA binding; modulation by virus of host morphology or physiology; nucleoplasm; nucleotide-excision repair, DNA damage removal; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of mitotic cell cycle phase transition" IPR004871; IPR015943; IPR017986; Protein modification; protein ubiquitination. DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe) DDB1 XAP1 Homo sapiens (Human) TR42093_c0_g1_i3 Q6P6Z0 DDB1_XENLA 1.00E-172 GO:0031464; GO:0031465; GO:0003677; GO:0006281; GO:0005737; GO:0005634; GO:0043161; GO:0016567 Cul4A-RING ubiquitin ligase complex; Cul4B-RING ubiquitin ligase complex; DNA binding; DNA repair; cytoplasm; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination IPR004871; IPR015943; IPR017986; Protein modification; protein ubiquitination. DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1) ddb1 Xenopus laevis (African clawed frog) TR42094_c1_g1_i1 Q00420 GABP1_MOUSE 1.00E-06 GO:0005634; GO:0045944; GO:0046982; GO:0044212; GO:0006351 "nucleus; positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR002110; IPR020683; GA-binding protein subunit beta-1 (GABP subunit beta-1) (GABPB-1) (GABP subunit beta-2) (GABPB-2) Gabpb1 Gabpb Gabpb2 Mus musculus (Mouse) TR42094_c1_g1_i2 Q5ZLC6 ANR10_CHICK 8.00E-33 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 10 ANKRD10 RCJMB04_6l10 Gallus gallus (Chicken) TR42094_c2_g2_i3 Q0VC93 ANR37_BOVIN 6.00E-13 GO:0005737; GO:0005634 cytoplasm; nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 37 ANKRD37 Bos taurus (Bovine) TR42095_c1_g1_i1 G5E8K5 ANK3_MOUSE 5.00E-17 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR42095_c2_g1_i3 Q9Z2X3 PSD10_RAT 7.00E-06 GO:0006915; GO:0005737; GO:0007253; GO:0043518; GO:0043409; GO:0032088; GO:0043066; GO:0090201; GO:0000122; GO:0005634; GO:0030307; GO:0045737; GO:0032436; GO:0031398; GO:0070682 "apoptotic process; cytoplasm; cytoplasmic sequestering of NF-kappaB; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of MAPK cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of apoptotic process; negative regulation of release of cytochrome c from mitochondria; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of cell growth; positive regulation of cyclin-dependent protein kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; proteasome regulatory particle assembly" IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) Psmd10 Rattus norvegicus (Rat) TR42095_c2_g1_i5 Q9Z2X3 PSD10_RAT 1.00E-06 GO:0006915; GO:0005737; GO:0007253; GO:0043518; GO:0043409; GO:0032088; GO:0043066; GO:0090201; GO:0000122; GO:0005634; GO:0030307; GO:0045737; GO:0032436; GO:0031398; GO:0070682 "apoptotic process; cytoplasm; cytoplasmic sequestering of NF-kappaB; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of MAPK cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of apoptotic process; negative regulation of release of cytochrome c from mitochondria; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of cell growth; positive regulation of cyclin-dependent protein kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; proteasome regulatory particle assembly" IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) Psmd10 Rattus norvegicus (Rat) TR42095_c2_g1_i6 Q9EQG6 KDIS_RAT 2.00E-06 GO:0030165; GO:0016482; GO:0005829; GO:0016021; GO:0005770; GO:0038180; GO:0010976; GO:0043234; GO:0019901; GO:0019887 P46109 PDZ domain binding; cytoplasmic transport; cytosol; integral to membrane; late endosome; nerve growth factor signaling pathway; positive regulation of neuron projection development; protein complex; protein kinase binding; protein kinase regulator activity IPR002110; IPR020683; IPR011646; IPR013761; Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) Kidins220 Arms Rattus norvegicus (Rat) TR42098_c0_g1_i1 Q9ULT8 HECD1_HUMAN 3.00E-18 GO:0005737; GO:0046872; GO:0001843; GO:0005634; GO:0042787; GO:0004842 cytoplasm; metal ion binding; neural tube closure; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR002110; IPR020683; IPR011989; IPR016024; IPR008979; IPR000569; IPR010606; IPR012919; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HECTD1 (EC 6.3.2.-) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) HECTD1 KIAA1131 Homo sapiens (Human) TR42098_c0_g2_i1 Q9HAU4 SMUF2_HUMAN 0 GO:0030509; GO:0005829; GO:0045121; GO:0000122; GO:0030512; GO:0005654; GO:0005886; GO:0042787; GO:0006367; GO:0007179; GO:0000151; GO:0030579; GO:0004842 Itself; Q9H469; Q9Y3C5; Q15796; P84022; P0CG47 BMP signaling pathway; cytosol; membrane raft; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; nucleoplasm; plasma membrane; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; ubiquitin ligase complex; ubiquitin-dependent SMAD protein catabolic process; ubiquitin-protein ligase activity IPR000008; IPR024928; IPR000569; IPR001202; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 6.3.2.-) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2) SMURF2 Homo sapiens (Human) TR42098_c0_g3_i1 A2A5Z6 SMUF2_MOUSE 1.00E-57 GO:0005737; GO:0045121; GO:0005634; GO:0005886; GO:0042787; GO:0007179; GO:0000151; GO:0030579; GO:0004842 O14641 cytoplasm; membrane raft; nucleus; plasma membrane; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; transforming growth factor beta receptor signaling pathway; ubiquitin ligase complex; ubiquitin-dependent SMAD protein catabolic process; ubiquitin-protein ligase activity IPR000008; IPR024928; IPR000569; IPR001202; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase SMURF2 (EC 6.3.2.-) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2) Smurf2 Mus musculus (Mouse) TR42101_c0_g1_i10 Q9NZN5 ARHGC_HUMAN 3.00E-79 GO:0001664; GO:0007186; GO:0005096; GO:0005089; GO:0097190; GO:0007411; GO:0005829; GO:0016020; GO:0048011; GO:0005543; GO:0043547; GO:0043065; GO:0035023; GO:0051056; GO:0007264; GO:0038032 P08069; P61793; P61586 G-protein coupled receptor binding; G-protein coupled receptor signaling pathway; GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; axon guidance; cytosol; membrane; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of GTPase activity; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; termination of G-protein coupled receptor signaling pathway IPR000219; IPR001331; IPR001478; IPR011993; IPR001849; IPR016137; IPR015212; IPR015721; Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) ARHGEF12 KIAA0382 LARG Homo sapiens (Human) TR42101_c0_g1_i12 Q9NZN5 ARHGC_HUMAN 1.00E-79 GO:0001664; GO:0007186; GO:0005096; GO:0005089; GO:0097190; GO:0007411; GO:0005829; GO:0016020; GO:0048011; GO:0005543; GO:0043547; GO:0043065; GO:0035023; GO:0051056; GO:0007264; GO:0038032 P08069; P61793; P61586 G-protein coupled receptor binding; G-protein coupled receptor signaling pathway; GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; axon guidance; cytosol; membrane; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of GTPase activity; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; termination of G-protein coupled receptor signaling pathway IPR000219; IPR001331; IPR001478; IPR011993; IPR001849; IPR016137; IPR015212; IPR015721; Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) ARHGEF12 KIAA0382 LARG Homo sapiens (Human) TR42101_c0_g1_i2 Q9NZN5 ARHGC_HUMAN 3.00E-79 GO:0001664; GO:0007186; GO:0005096; GO:0005089; GO:0097190; GO:0007411; GO:0005829; GO:0016020; GO:0048011; GO:0005543; GO:0043547; GO:0043065; GO:0035023; GO:0051056; GO:0007264; GO:0038032 P08069; P61793; P61586 G-protein coupled receptor binding; G-protein coupled receptor signaling pathway; GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; axon guidance; cytosol; membrane; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of GTPase activity; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; termination of G-protein coupled receptor signaling pathway IPR000219; IPR001331; IPR001478; IPR011993; IPR001849; IPR016137; IPR015212; IPR015721; Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) ARHGEF12 KIAA0382 LARG Homo sapiens (Human) TR42101_c0_g1_i6 Q9NZN5 ARHGC_HUMAN 3.00E-79 GO:0001664; GO:0007186; GO:0005096; GO:0005089; GO:0097190; GO:0007411; GO:0005829; GO:0016020; GO:0048011; GO:0005543; GO:0043547; GO:0043065; GO:0035023; GO:0051056; GO:0007264; GO:0038032 P08069; P61793; P61586 G-protein coupled receptor binding; G-protein coupled receptor signaling pathway; GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; axon guidance; cytosol; membrane; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of GTPase activity; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; termination of G-protein coupled receptor signaling pathway IPR000219; IPR001331; IPR001478; IPR011993; IPR001849; IPR016137; IPR015212; IPR015721; Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) ARHGEF12 KIAA0382 LARG Homo sapiens (Human) TR42101_c0_g1_i7 Q9NZN5 ARHGC_HUMAN 2.00E-79 GO:0001664; GO:0007186; GO:0005096; GO:0005089; GO:0097190; GO:0007411; GO:0005829; GO:0016020; GO:0048011; GO:0005543; GO:0043547; GO:0043065; GO:0035023; GO:0051056; GO:0007264; GO:0038032 P08069; P61793; P61586 G-protein coupled receptor binding; G-protein coupled receptor signaling pathway; GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; axon guidance; cytosol; membrane; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of GTPase activity; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; termination of G-protein coupled receptor signaling pathway IPR000219; IPR001331; IPR001478; IPR011993; IPR001849; IPR016137; IPR015212; IPR015721; Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) ARHGEF12 KIAA0382 LARG Homo sapiens (Human) TR42101_c0_g1_i8 Q6ZM86 GRD2I_DANRE 1.00E-06 GO:0030054; GO:0045211 cell junction; postsynaptic membrane IPR015425; IPR001478; "Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1)" grid2ip si:ch211-147h1.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR42101_c0_g1_i9 Q6ZM86 GRD2I_DANRE 1.00E-06 GO:0030054; GO:0045211 cell junction; postsynaptic membrane IPR015425; IPR001478; "Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1)" grid2ip si:ch211-147h1.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR42103_c4_g2_i1 Q92847 GHSR_HUMAN 3.00E-12 GO:0008154; GO:0008343; GO:0009986; GO:0032869; GO:0046697; GO:0001616; GO:0030252; GO:0016520; GO:0009755; GO:0016021; GO:0045121; GO:0050728; GO:0046676; GO:0032691; GO:0045409; GO:0042536; GO:0043005; GO:0017046; GO:0005886; GO:0032100; GO:0045923; GO:0043568; GO:0040018; GO:0043134; GO:0051963; GO:0032094 actin polymerization or depolymerization; adult feeding behavior; cell surface; cellular response to insulin stimulus; decidualization; growth hormone secretagogue receptor activity; growth hormone secretion; growth hormone-releasing hormone receptor activity; hormone-mediated signaling pathway; integral to membrane; membrane raft; negative regulation of inflammatory response; negative regulation of insulin secretion; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 biosynthetic process; negative regulation of tumor necrosis factor biosynthetic process; neuron projection; peptide hormone binding; plasma membrane; positive regulation of appetite; positive regulation of fatty acid metabolic process; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; regulation of hindgut contraction; regulation of synapse assembly; response to food IPR003905; IPR000276; IPR017452; Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) GHSR Homo sapiens (Human) TR42103_c4_g2_i4 P33535 OPRM_RAT 5.00E-06 GO:0001965; GO:0048149; GO:0004979; GO:0033554; GO:0007204; GO:0016021; GO:0038047; GO:0061358; GO:0007194; GO:0043951; GO:0045019; GO:0007200; GO:0005886; GO:0070374; GO:0043950; GO:0050769; GO:0045429; GO:0051481; GO:2000310; GO:0050795; GO:0019233; GO:0005245 Q812E9; P70498; P07825; Q6P689 G-protein alpha-subunit binding; behavioral response to ethanol; beta-endorphin receptor activity; cellular response to stress; elevation of cytosolic calcium ion concentration; integral to membrane; morphine receptor activity; negative regulation of Wnt protein secretion; negative regulation of adenylate cyclase activity; negative regulation of cAMP-mediated signaling; negative regulation of nitric oxide biosynthetic process; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; positive regulation of ERK1 and ERK2 cascade; positive regulation of cAMP-mediated signaling; positive regulation of neurogenesis; positive regulation of nitric oxide biosynthetic process; reduction of cytosolic calcium ion concentration; regulation of N-methyl-D-aspartate selective glutamate receptor activity; regulation of behavior; sensory perception of pain; voltage-gated calcium channel activity IPR000276; IPR017452; IPR000105; IPR001418; Mu-type opioid receptor (M-OR-1) (MOR-1) (Opioid receptor B) Oprm1 Ror-b Rattus norvegicus (Rat) TR42103_c4_g2_i5 Q9ESQ4 NMUR2_RAT 2.00E-09 GO:0005525; GO:0043006; GO:0050482; GO:0006816; GO:0007417; GO:0007204; GO:0007625; GO:0048016; GO:0016021; GO:0005229; GO:0042924; GO:0001607; GO:0008188; GO:0007200; GO:0005886; GO:0002023; GO:0048265 GTP binding; activation of phospholipase A2 activity by calcium-mediated signaling; arachidonic acid secretion; calcium ion transport; central nervous system development; elevation of cytosolic calcium ion concentration; grooming behavior; inositol phosphate-mediated signaling; integral to membrane; intracellular calcium activated chloride channel activity; neuromedin U binding; neuromedin U receptor activity; neuropeptide receptor activity; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; reduction of food intake in response to dietary excess; response to pain IPR000276; IPR017452; IPR005390; IPR005392; Neuromedin-U receptor 2 (NMU-R2) (G-protein coupled receptor TGR-1) (G-protein-coupled receptor FM-4) Nmur2 Tgr1 Rattus norvegicus (Rat) TR42103_c4_g2_i6 Q92847 GHSR_HUMAN 2.00E-12 GO:0008154; GO:0008343; GO:0009986; GO:0032869; GO:0046697; GO:0001616; GO:0030252; GO:0016520; GO:0009755; GO:0016021; GO:0045121; GO:0050728; GO:0046676; GO:0032691; GO:0045409; GO:0042536; GO:0043005; GO:0017046; GO:0005886; GO:0032100; GO:0045923; GO:0043568; GO:0040018; GO:0043134; GO:0051963; GO:0032094 actin polymerization or depolymerization; adult feeding behavior; cell surface; cellular response to insulin stimulus; decidualization; growth hormone secretagogue receptor activity; growth hormone secretion; growth hormone-releasing hormone receptor activity; hormone-mediated signaling pathway; integral to membrane; membrane raft; negative regulation of inflammatory response; negative regulation of insulin secretion; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 biosynthetic process; negative regulation of tumor necrosis factor biosynthetic process; neuron projection; peptide hormone binding; plasma membrane; positive regulation of appetite; positive regulation of fatty acid metabolic process; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; regulation of hindgut contraction; regulation of synapse assembly; response to food IPR003905; IPR000276; IPR017452; Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) GHSR Homo sapiens (Human) TR42103_c4_g2_i7 P90680 OPSB_APIME 1.00E-07 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR000856; IPR027430; "Opsin, blue-sensitive (Blue-sensitive opsin) (AmBLop)" BLOP Apis mellifera (Honeybee) TR42104_c2_g1_i1 Q96NN9 AIFM3_HUMAN 0 GO:0051537; GO:0045454; GO:0005783; GO:0097194; GO:0050660; GO:0046872; GO:0005743; GO:0016491 "2 iron, 2 sulfur cluster binding; cell redox homeostasis; endoplasmic reticulum; execution phase of apoptosis; flavin adenine dinucleotide binding; metal ion binding; mitochondrial inner membrane; oxidoreductase activity" IPR016156; IPR013027; IPR004099; IPR023753; IPR001327; IPR000103; IPR028202; IPR017941; Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor-like protein) AIFM3 AIFL Homo sapiens (Human) TR42104_c2_g1_i10 Q54H36 PYRD1_DICDI 1.00E-06 GO:0016491 oxidoreductase activity IPR013027; IPR023753; Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 (EC 1.8.1.-) pyroxd1 DDB_G0289727 Dictyostelium discoideum (Slime mold) TR42104_c2_g1_i11 Q96NN9 AIFM3_HUMAN 0 GO:0051537; GO:0045454; GO:0005783; GO:0097194; GO:0050660; GO:0046872; GO:0005743; GO:0016491 "2 iron, 2 sulfur cluster binding; cell redox homeostasis; endoplasmic reticulum; execution phase of apoptosis; flavin adenine dinucleotide binding; metal ion binding; mitochondrial inner membrane; oxidoreductase activity" IPR016156; IPR013027; IPR004099; IPR023753; IPR001327; IPR000103; IPR028202; IPR017941; Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor-like protein) AIFM3 AIFL Homo sapiens (Human) TR42104_c2_g1_i5 P80880 TRXB_BACSU 6.00E-08 GO:0005737; GO:0050660; GO:0019430; GO:0004791 cytoplasm; flavin adenine dinucleotide binding; removal of superoxide radicals; thioredoxin-disulfide reductase activity IPR013027; IPR008255; IPR023753; IPR001327; IPR000103; IPR005982; Thioredoxin reductase (TRXR) (EC 1.8.1.9) (General stress protein 35) (GSP35) trxB yvcH BSU34790 Bacillus subtilis (strain 168) TR42104_c2_g1_i6 Q07946 BEDA_PSEPU 6.00E-42 GO:0019439; GO:0045454; GO:0008860; GO:0050660 aromatic compound catabolic process; cell redox homeostasis; ferredoxin-NAD+ reductase activity; flavin adenine dinucleotide binding IPR016156; IPR013027; IPR004099; IPR023753; IPR001327; IPR028202; Aromatic compound metabolism; benzene degradation; catechol from benzene: step 1/2. "Benzene 1,2-dioxygenase system ferredoxin--NAD(+) reductase subunit (EC 1.18.1.3)" bedA Pseudomonas putida (Arthrobacter siderocapsulatus) TR42104_c2_g1_i7 Q96NN9 AIFM3_HUMAN 0 GO:0051537; GO:0045454; GO:0005783; GO:0097194; GO:0050660; GO:0046872; GO:0005743; GO:0016491 "2 iron, 2 sulfur cluster binding; cell redox homeostasis; endoplasmic reticulum; execution phase of apoptosis; flavin adenine dinucleotide binding; metal ion binding; mitochondrial inner membrane; oxidoreductase activity" IPR016156; IPR013027; IPR004099; IPR023753; IPR001327; IPR000103; IPR028202; IPR017941; Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor-like protein) AIFM3 AIFL Homo sapiens (Human) TR42104_c2_g1_i8 P43783 GSHR_HAEIN 1.00E-13 GO:0050661; GO:0045454; GO:0005737; GO:0050660; GO:0006749; GO:0004362 NADP binding; cell redox homeostasis; cytoplasm; flavin adenine dinucleotide binding; glutathione metabolic process; glutathione-disulfide reductase activity IPR016156; IPR013027; IPR006322; IPR004099; IPR023753; IPR012999; IPR001327; Glutathione reductase (GR) (GRase) (EC 1.8.1.7) gor HI_0161 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) TR42105_c0_g1_i2 Q28HY5 CP072_XENTR 4.00E-51 UPF0472 protein C16orf72 homolog TEgg029f10.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42105_c0_g1_i3 Q28HY5 CP072_XENTR 3.00E-51 UPF0472 protein C16orf72 homolog TEgg029f10.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42107_c1_g1_i1 Q6P9B9 INT5_HUMAN 1.00E-74 GO:0016021; GO:0032039; GO:0016180 integral to membrane; integrator complex; snRNA processing Integrator complex subunit 5 (Int5) INTS5 KIAA1698 Homo sapiens (Human) TR42107_c1_g1_i2 Q8CHT3 INT5_MOUSE 3.00E-75 GO:0016021; GO:0032039; GO:0016180 integral to membrane; integrator complex; snRNA processing Integrator complex subunit 5 (Int5) Ints5 Mus musculus (Mouse) TR42107_c1_g2_i3 Q8CHT3 INT5_MOUSE 6.00E-44 GO:0016021; GO:0032039; GO:0016180 integral to membrane; integrator complex; snRNA processing Integrator complex subunit 5 (Int5) Ints5 Mus musculus (Mouse) TR42107_c2_g1_i1 Q8N9R8 SCAI_HUMAN 1.00E-39 GO:0005737; GO:0016021; GO:0035024; GO:0030336; GO:0005634; GO:0006355; GO:0003714; GO:0006351 "cytoplasm; integral to membrane; negative regulation of Rho protein signal transduction; negative regulation of cell migration; nucleus; regulation of transcription, DNA-dependent; transcription corepressor activity; transcription, DNA-dependent" IPR022709; IPR016607; Protein SCAI (Suppressor of cancer cell invasion protein) SCAI C9orf126 Homo sapiens (Human) TR42108_c0_g3_i2 Q99575 POP1_HUMAN 2.00E-87 GO:0005655; GO:0000171; GO:0000172; GO:0004526; GO:0001682; GO:0016078 O95707 nucleolar ribonuclease P complex; ribonuclease MRP activity; ribonuclease MRP complex; ribonuclease P activity; tRNA 5'-leader removal; tRNA catabolic process IPR012590; IPR009723; Ribonucleases P/MRP protein subunit POP1 (hPOP1) (EC 3.1.26.5) POP1 KIAA0061 Homo sapiens (Human) TR42108_c0_g3_i4 Q9UTA4 POPI_SCHPO 2.00E-13 GO:0006379; GO:0005655; GO:0006364; GO:0000172; GO:0004526; GO:0001682 mRNA cleavage; nucleolar ribonuclease P complex; rRNA processing; ribonuclease MRP complex; ribonuclease P activity; tRNA 5'-leader removal IPR012590; IPR009723; Ribonucleases P/MRP protein subunit pop1 (EC 3.1.26.5) pop1 SPAC25B8.16 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42109_c0_g1_i1 Q96MM6 HS12B_HUMAN 3.00E-13 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR42109_c2_g2_i3 Q49539 DNAK_MYCH2 1.00E-09 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (65 kDa protein) (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) (P65) dnaK mhp072 Mycoplasma hyopneumoniae (strain 232) TR42109_c2_g2_i7 O43301 HS12A_HUMAN 6.00E-96 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR42110_c1_g2_i3 Q6DGQ0 SPT4H_DANRE 1.00E-54 GO:0032044; GO:0032786; GO:0006351; GO:0008270 "DSIF complex; positive regulation of DNA-dependent transcription, elongation; transcription, DNA-dependent; zinc ion binding" IPR009287; IPR016046; IPR022800; Transcription elongation factor SPT4 (DRB sensitivity-inducing factor small subunit) (DSIF small subunit) supt4h1 zgc:92824 Danio rerio (Zebrafish) (Brachydanio rerio) TR42111_c1_g1_i4 Q24372 LACH_DROME 2.00E-29 GO:0031225; GO:0061343; GO:0007156; GO:0035160; GO:0016331; GO:0005886; GO:0042803; GO:0035151; GO:0005918; GO:0019991 Q9VGH2 "anchored to membrane; cell adhesion involved in heart morphogenesis; homophilic cell adhesion; maintenance of epithelial integrity, open tracheal system; morphogenesis of embryonic epithelium; plasma membrane; protein homodimerization activity; regulation of tube size, open tracheal system; septate junction; septate junction assembly" IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Lachesin Lac CG12369 Drosophila melanogaster (Fruit fly) TR42112_c0_g3_i1 Q8IYK8 REM2_HUMAN 2.00E-08 GO:0005525; GO:0003924; GO:0005886; GO:0007264 GTP binding; GTPase activity; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR025662; IPR001806; IPR017358; IPR020849; GTP-binding protein REM 2 (Rad and Gem-like GTP-binding protein 2) REM2 Homo sapiens (Human) TR42112_c0_g3_i2 P55042 RAD_HUMAN 1.00E-09 GO:0005525; GO:0003924; GO:0005886; GO:0007264 O95273 GTP binding; GTPase activity; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR017358; IPR020849; GTP-binding protein RAD (RAD1) (Ras associated with diabetes) RRAD RAD Homo sapiens (Human) TR42112_c0_g3_i3 P55042 RAD_HUMAN 9.00E-16 GO:0005525; GO:0003924; GO:0005886; GO:0007264 O95273 GTP binding; GTPase activity; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR017358; IPR020849; GTP-binding protein RAD (RAD1) (Ras associated with diabetes) RRAD RAD Homo sapiens (Human) TR42112_c0_g3_i5 Q9D8T3 REBL1_MOUSE 1.00E-08 GO:0005525; GO:0003924; GO:0031929; GO:0005737; GO:0005886; GO:0051092; GO:0007264 GTP binding; GTPase activity; TOR signaling cascade; cytoplasm; plasma membrane; positive regulation of NF-kappaB transcription factor activity; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR020849; GTPase RhebL1 (Ras homolog enriched in brain-like protein 1) (Rheb-like protein 1) Rhebl1 Mus musculus (Mouse) TR42114_c0_g3_i1 Q62393 TPD52_MOUSE 5.00E-28 GO:0030183; GO:0005509; GO:0005783; GO:0048471; GO:0046982; GO:0042803 P55327; Q16890; O43399-2 B cell differentiation; calcium ion binding; endoplasmic reticulum; perinuclear region of cytoplasm; protein heterodimerization activity; protein homodimerization activity IPR007327; Tumor protein D52 (mD52) Tpd52 Mus musculus (Mouse) TR42114_c0_g3_i4 O43399 TPD54_HUMAN 7.00E-36 GO:0048471; GO:0042803; GO:0042127 Q62393 perinuclear region of cytoplasm; protein homodimerization activity; regulation of cell proliferation IPR007327; Tumor protein D54 (hD54) (Tumor protein D52-like 2) TPD52L2 Homo sapiens (Human) TR42115_c0_g1_i3 Q9W596 FUTSC_DROME 3.00E-08 GO:0008088; GO:0007409; GO:0048749; GO:0005737; GO:0048813; GO:0016787; GO:0005874; GO:0005875; GO:0008017; GO:0000226; GO:0043524; GO:0060052; GO:0007528; GO:0008355; GO:0008582 axon cargo transport; axonogenesis; compound eye development; cytoplasm; dendrite morphogenesis; hydrolase activity; microtubule; microtubule associated complex; microtubule binding; microtubule cytoskeleton organization; negative regulation of neuron apoptotic process; neurofilament cytoskeleton organization; neuromuscular junction development; olfactory learning; regulation of synaptic growth at neuromuscular junction IPR001279; IPR026074; IPR009603; Microtubule-associated protein futsch (MAP1B homolog) [Cleaved into: Futsch heavy chain; Futsch light chain LC(f)] futsch CG34387 Drosophila melanogaster (Fruit fly) TR42115_c0_g2_i2 P14873 MAP1B_MOUSE 2.00E-85 GO:0048675; GO:0030054; GO:0005519; GO:0005829; GO:0016358; GO:0043197; GO:0061162; GO:0016787; GO:0005874; GO:0005875; GO:0001578; GO:0047497; GO:0032387; GO:0005886; GO:0045773; GO:0045202 Q9WTU3 axon extension; cell junction; cytoskeletal regulatory protein binding; cytosol; dendrite development; dendritic spine; establishment of monopolar cell polarity; hydrolase activity; microtubule; microtubule associated complex; microtubule bundle formation; mitochondrion transport along microtubule; negative regulation of intracellular transport; plasma membrane; positive regulation of axon extension; synapse IPR001279; IPR026074; IPR027321; IPR000102; Microtubule-associated protein 1B (MAP-1B) (MAP1(X)) (MAP1.2) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Map1b Mtap1b Mtap5 Mus musculus (Mouse) TR42115_c0_g2_i4 Q9W596 FUTSC_DROME 8.00E-115 GO:0008088; GO:0007409; GO:0048749; GO:0005737; GO:0048813; GO:0016787; GO:0005874; GO:0005875; GO:0008017; GO:0000226; GO:0043524; GO:0060052; GO:0007528; GO:0008355; GO:0008582 axon cargo transport; axonogenesis; compound eye development; cytoplasm; dendrite morphogenesis; hydrolase activity; microtubule; microtubule associated complex; microtubule binding; microtubule cytoskeleton organization; negative regulation of neuron apoptotic process; neurofilament cytoskeleton organization; neuromuscular junction development; olfactory learning; regulation of synaptic growth at neuromuscular junction IPR001279; IPR026074; IPR009603; Microtubule-associated protein futsch (MAP1B homolog) [Cleaved into: Futsch heavy chain; Futsch light chain LC(f)] futsch CG34387 Drosophila melanogaster (Fruit fly) TR42115_c0_g2_i7 Q9W596 FUTSC_DROME 1.00E-121 GO:0008088; GO:0007409; GO:0048749; GO:0005737; GO:0048813; GO:0016787; GO:0005874; GO:0005875; GO:0008017; GO:0000226; GO:0043524; GO:0060052; GO:0007528; GO:0008355; GO:0008582 axon cargo transport; axonogenesis; compound eye development; cytoplasm; dendrite morphogenesis; hydrolase activity; microtubule; microtubule associated complex; microtubule binding; microtubule cytoskeleton organization; negative regulation of neuron apoptotic process; neurofilament cytoskeleton organization; neuromuscular junction development; olfactory learning; regulation of synaptic growth at neuromuscular junction IPR001279; IPR026074; IPR009603; Microtubule-associated protein futsch (MAP1B homolog) [Cleaved into: Futsch heavy chain; Futsch light chain LC(f)] futsch CG34387 Drosophila melanogaster (Fruit fly) TR42116_c1_g3_i1 Q99MQ3 PINK1_MOUSE 9.00E-57 GO:0005524; GO:0010857; GO:0097237; GO:0005829; GO:0016021; GO:0007243; GO:0000287; GO:0005741; GO:0005739; GO:0000422; GO:0043524; GO:0018105; GO:0043123; GO:0033603; GO:0090200; GO:0032226; GO:0004674; GO:0043254; GO:0031396; GO:0006950 "ATP binding; calcium-dependent protein kinase activity; cellular response to toxic substance; cytosol; integral to membrane; intracellular protein kinase cascade; magnesium ion binding; mitochondrial outer membrane; mitochondrion; mitochondrion degradation; negative regulation of neuron apoptotic process; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of dopamine secretion; positive regulation of release of cytochrome c from mitochondria; positive regulation of synaptic transmission, dopaminergic; protein serine/threonine kinase activity; regulation of protein complex assembly; regulation of protein ubiquitination; response to stress" IPR011009; IPR000719; IPR017441; IPR008271; "Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)" Pink1 Mus musculus (Mouse) TR42116_c1_g3_i3 Q99MQ3 PINK1_MOUSE 8.00E-57 GO:0005524; GO:0010857; GO:0097237; GO:0005829; GO:0016021; GO:0007243; GO:0000287; GO:0005741; GO:0005739; GO:0000422; GO:0043524; GO:0018105; GO:0043123; GO:0033603; GO:0090200; GO:0032226; GO:0004674; GO:0043254; GO:0031396; GO:0006950 "ATP binding; calcium-dependent protein kinase activity; cellular response to toxic substance; cytosol; integral to membrane; intracellular protein kinase cascade; magnesium ion binding; mitochondrial outer membrane; mitochondrion; mitochondrion degradation; negative regulation of neuron apoptotic process; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of dopamine secretion; positive regulation of release of cytochrome c from mitochondria; positive regulation of synaptic transmission, dopaminergic; protein serine/threonine kinase activity; regulation of protein complex assembly; regulation of protein ubiquitination; response to stress" IPR011009; IPR000719; IPR017441; IPR008271; "Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)" Pink1 Mus musculus (Mouse) TR42117_c2_g1_i1 Q3ZBT2 FBX9_BOVIN 2.00E-102 GO:0019005; GO:0031146; GO:0005737; GO:0016567; GO:0032006 SCF ubiquitin ligase complex; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cytoplasm; protein ubiquitination; regulation of TOR signaling cascade IPR001810; Protein modification; protein ubiquitination. F-box only protein 9 FBXO9 Bos taurus (Bovine) TR42118_c0_g2_i1 P11369 POL2_MOUSE 1.00E-38 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR013544; IPR005135; IPR000477; Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element-1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] Pol Gm17492 Mus musculus (Mouse) TR42118_c0_g2_i3 P08548 LIN1_NYCCO 7.00E-37 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR42121_c2_g1_i2 P49760 CLK2_HUMAN 0 GO:0005524; GO:0045721; GO:0016607; GO:0005634; GO:0046777; GO:0004674; GO:0004712; GO:0004713; GO:0043484; GO:0010212; GO:0032526 P49761; P08621 ATP binding; negative regulation of gluconeogenesis; nuclear speck; nucleus; protein autophosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; regulation of RNA splicing; response to ionizing radiation; response to retinoic acid IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) CLK2 Homo sapiens (Human) TR42121_c2_g1_i4 P51566 AFC1_ARATH 2.00E-96 GO:0005524; GO:0004674; GO:0004712; GO:0006355 "ATP binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; regulation of transcription, DNA-dependent" IPR011009; IPR000719; IPR002290; IPR008271; Serine/threonine-protein kinase AFC1 (EC 2.7.12.1) AFC1 AME2 At3g53570 F4P12_270 Arabidopsis thaliana (Mouse-ear cress) TR42121_c2_g1_i5 P32350 KNS1_YEAST 1.00E-70 GO:0005524; GO:0005737; GO:0016480; GO:0005634; GO:0046777; GO:0004674; GO:0004712; GO:0004713 ATP binding; cytoplasm; negative regulation of transcription from RNA polymerase III promoter; nucleus; protein autophosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity protein kinase KNS1 (EC 2.7.12.1) KNS1 YLL019C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42121_c2_g1_i7 O35491 CLK2_MOUSE 3.00E-170 GO:0005524; GO:0045721; GO:0016607; GO:0005634; GO:0046777; GO:0004674; GO:0004712; GO:0004713; GO:0043484; GO:0010212; GO:0032526 ATP binding; negative regulation of gluconeogenesis; nuclear speck; nucleus; protein autophosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; regulation of RNA splicing; response to ionizing radiation; response to retinoic acid IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) Clk2 Mus musculus (Mouse) TR42124_c4_g2_i2 P13834 GYS1_RABIT 0 GO:0004373; GO:0005978 glycogen (starch) synthase activity; glycogen biosynthetic process IPR008631; Glycan biosynthesis; glycogen biosynthesis. "Glycogen [starch] synthase, muscle (EC 2.4.1.11)" GYS1 GYS Oryctolagus cuniculus (Rabbit) TR42124_c4_g2_i3 Q9VFC8 GYS_DROME 0 GO:0004373; GO:0005978 glycogen (starch) synthase activity; glycogen biosynthetic process IPR008631; Glycan biosynthesis; glycogen biosynthesis. Putative glycogen [starch] synthase (EC 2.4.1.11) CG6904 Drosophila melanogaster (Fruit fly) TR42124_c4_g2_i5 Q9VFC8 GYS_DROME 0 GO:0004373; GO:0005978 glycogen (starch) synthase activity; glycogen biosynthetic process IPR008631; Glycan biosynthesis; glycogen biosynthesis. Putative glycogen [starch] synthase (EC 2.4.1.11) CG6904 Drosophila melanogaster (Fruit fly) TR42126_c1_g1_i1 Q70E20 SNED1_MOUSE 3.00E-28 GO:0005509; GO:0007160; GO:0005576 calcium ion binding; cell-matrix adhesion; extracellular region IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003961; IPR009030; IPR013783; IPR003886; IPR000436; "Sushi, nidogen and EGF-like domain-containing protein 1 (Secreted protein SST-3) (Stromal nidogen extracellular matrix protein)" Sned1 Snep Mus musculus (Mouse) TR42126_c1_g1_i2 O88277 FAT2_RAT 4.00E-16 GO:0005509; GO:0005913; GO:0010631; GO:0007156; GO:0016021; GO:0005634; GO:0005886 calcium ion binding; cell-cell adherens junction; epithelial cell migration; homophilic cell adhesion; integral to membrane; nucleus; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR013032; IPR001791; Protocadherin Fat 2 (Multiple epidermal growth factor-like domains protein 1) (Multiple EGF-like domains protein 1) Fat2 Fath2 Megf1 Rattus norvegicus (Rat) TR42126_c1_g2_i2 Q9Y6R7 FCGBP_HUMAN 6.00E-08 GO:0005737; GO:0005576 cytoplasm; extracellular region IPR003645; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) TR42127_c5_g3_i2 O43301 HS12A_HUMAN 1.00E-36 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR42127_c5_g4_i1 Q96MM6 HS12B_HUMAN 4.00E-36 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR42128_c0_g1_i1 Q3MHU3 TDRD9_RAT 2.00E-91 GO:0005524; GO:0008026; GO:0043046; GO:0030154; GO:0009566; GO:0031047; GO:0007140; GO:0007275; GO:0003676; GO:0005634; GO:0071547; GO:0034587; GO:0007283 ATP binding; ATP-dependent helicase activity; DNA methylation involved in gamete generation; cell differentiation; fertilization; gene silencing by RNA; male meiosis; multicellular organismal development; nucleic acid binding; nucleus; piP-body; piRNA metabolic process; spermatogenesis IPR011545; IPR007502; IPR014001; IPR001650; IPR027417; IPR002999; Putative ATP-dependent RNA helicase TDRD9 (EC 3.6.4.13) (Tudor domain-containing protein 9) Tdrd9 Rattus norvegicus (Rat) TR42128_c1_g2_i1 Q9Y2W6 TDRKH_HUMAN 6.00E-12 GO:0043046; GO:0003723; GO:0030154; GO:0009566; GO:0031047; GO:0007140; GO:0005739; GO:0071546; GO:0071547; GO:0034587; GO:0007283 DNA methylation involved in gamete generation; RNA binding; cell differentiation; fertilization; gene silencing by RNA; male meiosis; mitochondrion; pi-body; piP-body; piRNA metabolic process; spermatogenesis IPR004087; IPR004088; IPR002999; Tudor and KH domain-containing protein (Tudor domain-containing protein 2) TDRKH TDRD2 Homo sapiens (Human) TR42128_c1_g3_i1 Q3MHU3 TDRD9_RAT 4.00E-138 GO:0005524; GO:0008026; GO:0043046; GO:0030154; GO:0009566; GO:0031047; GO:0007140; GO:0007275; GO:0003676; GO:0005634; GO:0071547; GO:0034587; GO:0007283 ATP binding; ATP-dependent helicase activity; DNA methylation involved in gamete generation; cell differentiation; fertilization; gene silencing by RNA; male meiosis; multicellular organismal development; nucleic acid binding; nucleus; piP-body; piRNA metabolic process; spermatogenesis IPR011545; IPR007502; IPR014001; IPR001650; IPR027417; IPR002999; Putative ATP-dependent RNA helicase TDRD9 (EC 3.6.4.13) (Tudor domain-containing protein 9) Tdrd9 Rattus norvegicus (Rat) TR42129_c1_g1_i2 Q0IHV1 INF2_XENTR 2.00E-59 GO:0030036 actin cytoskeleton organization IPR016024; IPR015425; IPR010472; IPR010473; IPR014768; IPR003124; Inverted formin-2 inf2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42129_c1_g1_i3 Q8BPM0 DAAM1_MOUSE 1.00E-11 GO:0030036; GO:0005737; GO:0005886; GO:0001725 O15085-2 actin cytoskeleton organization; cytoplasm; plasma membrane; stress fiber IPR011989; IPR016024; IPR027650; IPR014767; IPR015425; IPR010472; IPR010473; IPR014768; Disheveled-associated activator of morphogenesis 1 Daam1 Mus musculus (Mouse) TR42129_c1_g1_i6 Q9C0D6 FHDC1_HUMAN 1.00E-15 IPR015425; FH2 domain-containing protein 1 FHDC1 KIAA1727 Homo sapiens (Human) TR42129_c1_g2_i1 Q0GNC1 INF2_MOUSE 1.00E-46 GO:0030036; GO:0048471; GO:0032535 actin cytoskeleton organization; perinuclear region of cytoplasm; regulation of cellular component size IPR016024; IPR015425; IPR010472; IPR010473; IPR014768; IPR027649; IPR003124; Inverted formin-2 Inf2 Mus musculus (Mouse) TR42130_c0_g6_i1 Q96S53 TESK2_HUMAN 2.00E-121 GO:0005524; GO:0030036; GO:0005737; GO:0048041; GO:0046872; GO:0005634; GO:0018108; GO:0004674; GO:0004712; GO:0004713; GO:0007283 P08238 ATP binding; actin cytoskeleton organization; cytoplasm; focal adhesion assembly; metal ion binding; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; spermatogenesis IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2) TESK2 Homo sapiens (Human) TR42132_c0_g1_i1 P33992 MCM5_HUMAN 2.00E-82 GO:0005524; GO:0003677; GO:0032508; GO:0003678; GO:0006270; GO:0006271; GO:0000082; GO:0042555; GO:0005654 P62805; P49736; P25205; P33993; Q9BTE3 ATP binding; DNA binding; DNA duplex unwinding; DNA helicase activity; DNA replication initiation; DNA strand elongation involved in DNA replication; G1/S transition of mitotic cell cycle; MCM complex; nucleoplasm IPR008048; IPR018525; IPR001208; IPR027925; IPR012340; IPR027417; DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46) MCM5 CDC46 Homo sapiens (Human) TR42132_c0_g1_i3 Q6GL41 MCM4_XENTR 0 GO:0005524; GO:0006200; GO:0003677; GO:0003678; GO:0006270; GO:0006268; GO:0042555; GO:0007049; GO:0000785; GO:0046872; GO:0005634; GO:0030174 ATP binding; ATP catabolic process; DNA binding; DNA helicase activity; DNA replication initiation; DNA unwinding involved in DNA replication; MCM complex; cell cycle; chromatin; metal ion binding; nucleus; regulation of DNA-dependent DNA replication initiation IPR003593; IPR008047; IPR018525; IPR001208; IPR027925; IPR012340; IPR027417; IPR004039; DNA replication licensing factor mcm4 (EC 3.6.4.12) (Minichromosome maintenance protein 4) mcm4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42132_c0_g1_i4 P30665 MCM4_YEAST 0 GO:0005524; GO:0003678; GO:0006270; GO:0003688; GO:0031261; GO:0006271; GO:0006268; GO:0042555; GO:0097373; GO:0005737; GO:0000727; GO:0005656; GO:0006267; GO:0031298; GO:0003697 P32354; P29469; P53091; P38132 ATP binding; DNA helicase activity; DNA replication initiation; DNA replication origin binding; DNA replication preinitiation complex; DNA strand elongation involved in DNA replication; DNA unwinding involved in DNA replication; MCM complex; MCM core complex; cytoplasm; double-strand break repair via break-induced replication; nuclear pre-replicative complex; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; replication fork protection complex; single-stranded DNA binding IPR008047; IPR018525; IPR001208; IPR027925; IPR012340; IPR027417; IPR004039; DNA replication licensing factor MCM4 (EC 3.6.4.12) (Cell division control protein 54) MCM4 CDC54 HCD21 YPR019W YP9531.13 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42132_c0_g1_i5 Q6GL41 MCM4_XENTR 1.00E-127 GO:0005524; GO:0006200; GO:0003677; GO:0003678; GO:0006270; GO:0006268; GO:0042555; GO:0007049; GO:0000785; GO:0046872; GO:0005634; GO:0030174 ATP binding; ATP catabolic process; DNA binding; DNA helicase activity; DNA replication initiation; DNA unwinding involved in DNA replication; MCM complex; cell cycle; chromatin; metal ion binding; nucleus; regulation of DNA-dependent DNA replication initiation IPR003593; IPR008047; IPR018525; IPR001208; IPR027925; IPR012340; IPR027417; IPR004039; DNA replication licensing factor mcm4 (EC 3.6.4.12) (Minichromosome maintenance protein 4) mcm4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42133_c0_g2_i1 Q9GMB0 RPN1_PIG 1.00E-116 GO:0004579; GO:0005789; GO:0016021; GO:0042470; GO:0006486 dolichyl-diphosphooligosaccharide-protein glycotransferase activity; endoplasmic reticulum membrane; integral to membrane; melanosome; protein glycosylation IPR007676; Protein modification; protein glycosylation. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (EC 2.4.99.18) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) RPN1 Sus scrofa (Pig) TR42133_c0_g3_i1 Q54C27 OST1_DICDI 5.00E-42 GO:0004579; GO:0016021; GO:0008250; GO:0006487 dolichyl-diphosphooligosaccharide-protein glycotransferase activity; integral to membrane; oligosaccharyltransferase complex; protein N-linked glycosylation IPR007676; Protein modification; protein glycosylation. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (EC 2.4.99.18) (Oligosaccharyl transferase subunit alpha) (Ribophorin I) (RPN-I) (Ribophorin-1) ost1 rpn1 DDB_G0293224 Dictyostelium discoideum (Slime mold) TR42133_c0_g3_i2 Q10176 OST1_SCHPO 3.00E-09 GO:0004579; GO:0016021; GO:0008250; GO:0006487 dolichyl-diphosphooligosaccharide-protein glycotransferase activity; integral to membrane; oligosaccharyltransferase complex; protein N-linked glycosylation IPR007676; Protein modification; protein glycosylation. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (EC 2.4.99.18) (Oligosaccharyl transferase subunit alpha) ost1 SPAC27F1.07 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42134_c1_g1_i5 Q9UPN6 SCAF8_HUMAN 3.00E-65 GO:0003723; GO:0008380; GO:0006397; GO:0016363; GO:0000166; GO:0005681 RNA binding; RNA splicing; mRNA processing; nuclear matrix; nucleotide binding; spliceosomal complex IPR006569; IPR008942; IPR012677; IPR006903; IPR000504; Protein SCAF8 (CDC5L complex-associated protein 7) (RNA-binding motif protein 16) (SR-related and CTD-associated factor 8) SCAF8 CCAP7 KIAA1116 RBM16 Homo sapiens (Human) TR42136_c0_g1_i2 P33767 OSTB_YEAST 3.00E-19 GO:0004579; GO:0016021; GO:0000278; GO:0005635; GO:0008250; GO:0006487; GO:0018279 P53622; P52870; P32915; P35179; P39007; Q02795 dolichyl-diphosphooligosaccharide-protein glycotransferase activity; integral to membrane; mitotic cell cycle; nuclear envelope; oligosaccharyltransferase complex; protein N-linked glycosylation; protein N-linked glycosylation via asparagine IPR005013; Protein modification; protein glycosylation. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1 (Oligosaccharyl transferase subunit WBP1) (EC 2.4.99.18) (Oligosaccharyl transferase subunit beta) WBP1 YEL002C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42136_c0_g2_i2 Q05052 OST48_CANFA 3.00E-132 GO:0004579; GO:0016021; GO:0008250; GO:0018279; GO:0006486 dolichyl-diphosphooligosaccharide-protein glycotransferase activity; integral to membrane; oligosaccharyltransferase complex; protein N-linked glycosylation via asparagine; protein glycosylation IPR005013; Protein modification; protein glycosylation. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit) (EC 2.4.99.18) DDOST OST48 Canis familiaris (Dog) (Canis lupus familiaris) TR42137_c0_g1_i2 Q53H80 AKIR2_HUMAN 1.00E-32 GO:0009790; GO:0045087; GO:0000122; GO:0008284; GO:0010950; GO:0032755; GO:0045944; GO:0032496; GO:0006351; GO:0017053 "embryo development; innate immune response; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation; positive regulation of endopeptidase activity; positive regulation of interleukin-6 production; positive regulation of transcription from RNA polymerase II promoter; response to lipopolysaccharide; transcription, DNA-dependent; transcriptional repressor complex" IPR024132; Akirin-2 AKIRIN2 C6orf166 Homo sapiens (Human) TR42138_c0_g1_i1 P52747 ZN143_HUMAN 2.00E-09 GO:0003677; GO:0046872; GO:0005654; GO:0006357; GO:0006359; GO:0006366; GO:0006383 DNA binding; metal ion binding; nucleoplasm; regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase III promoter; transcription from RNA polymerase II promoter; transcription from RNA polymerase III promoter IPR007087; IPR015880; IPR013087; Zinc finger protein 143 (SPH-binding factor) (Selenocysteine tRNA gene transcription-activating factor) (hStaf) ZNF143 SBF STAF Homo sapiens (Human) TR42138_c0_g1_i2 Q8N554 ZN276_HUMAN 4.00E-14 GO:0003677; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR012934; IPR007087; IPR015880; IPR013087; Zinc finger protein 276 (Zfp-276) (Zinc finger protein 477) ZNF276 ZFP276 ZNF477 Homo sapiens (Human) TR42139_c0_g1_i10 Q9P2P5 HECW2_HUMAN 1.00E-159 GO:0005737; GO:0005634; GO:0042787; GO:0004842 cytoplasm; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000008; IPR000569; IPR001202; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase HECW2 (EC 6.3.2.-) (HECT, C2 and WW domain-containing protein 2) (NEDD4-like E3 ubiquitin-protein ligase 2)" HECW2 KIAA1301 NEDL2 Homo sapiens (Human) TR42139_c0_g1_i2 Q6I6G8 HECW2_MOUSE 0 GO:0005737; GO:0005634; GO:0042787; GO:0004842 cytoplasm; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000008; IPR000569; IPR001202; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase HECW2 (EC 6.3.2.-) (HECT, C2 and WW domain-containing protein 2) (NEDD4-like E3 ubiquitin-protein ligase 2)" Hecw2 Kiaa1301 Nedl2 Mus musculus (Mouse) TR42139_c0_g1_i3 Q6I6G8 HECW2_MOUSE 0 GO:0005737; GO:0005634; GO:0042787; GO:0004842 cytoplasm; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000008; IPR000569; IPR001202; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase HECW2 (EC 6.3.2.-) (HECT, C2 and WW domain-containing protein 2) (NEDD4-like E3 ubiquitin-protein ligase 2)" Hecw2 Kiaa1301 Nedl2 Mus musculus (Mouse) TR42141_c2_g1_i2 Q9CZJ2 HS12B_MOUSE 9.00E-97 GO:0005524 ATP binding Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) TR42141_c2_g1_i6 O43301 HS12A_HUMAN 2.00E-96 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR42141_c2_g1_i8 Q8K0U4 HS12A_MOUSE 3.00E-86 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR42142_c3_g1_i1 Q9Z7N9 UHPT_CHLPN 7.00E-13 GO:0008643; GO:0016021; GO:0005886; GO:0055085; GO:0005215 carbohydrate transport; integral to membrane; plasma membrane; transmembrane transport; transporter activity IPR011701; IPR020846; IPR016196; IPR021159; IPR000849; Probable hexose phosphate transport protein uhpC CPn_0665 CP_0082 CpB0691 Chlamydia pneumoniae (Chlamydophila pneumoniae) TR42142_c3_g1_i2 Q5M7K3 SPX2_XENTR 2.00E-105 GO:0008643; GO:0016021; GO:0055085; GO:0005215 carbohydrate transport; integral to membrane; transmembrane transport; transporter activity IPR011701; IPR020846; IPR016196; IPR000849; Sugar phosphate exchanger 2 (Solute carrier family 37 member 2) slc37a2 spx2 TEgg043o11.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42142_c3_g1_i3 Q58CV5 SPX2_BOVIN 9.00E-100 GO:0008643; GO:0016021; GO:0055085; GO:0005215 carbohydrate transport; integral to membrane; transmembrane transport; transporter activity IPR011701; IPR020846; IPR016196; IPR000849; Sugar phosphate exchanger 2 (Solute carrier family 37 member 2) SLC37A2 SPX2 Bos taurus (Bovine) TR42142_c3_g4_i1 Q7SY29 SPX2_DANRE 1.00E-65 GO:0008643; GO:0016021; GO:0055085; GO:0005215 carbohydrate transport; integral to membrane; transmembrane transport; transporter activity IPR011701; IPR020846; IPR016196; IPR000849; Sugar phosphate exchanger 2 (Solute carrier family 37 member 2) slc37a2 spx2 zgc:63583 Danio rerio (Zebrafish) (Brachydanio rerio) TR42143_c0_g3_i1 Q9CZU3 SK2L2_MOUSE 0 GO:0005524; GO:0008026; GO:0008380; GO:0071013; GO:0000178; GO:0006397; GO:0000460; GO:0003676; GO:0005730 ATP binding; ATP-dependent helicase activity; RNA splicing; catalytic step 2 spliceosome; exosome (RNase complex); mRNA processing; maturation of 5.8S rRNA; nucleic acid binding; nucleolus IPR011545; IPR012961; IPR014001; IPR001650; IPR027417; IPR016438; IPR025696; Superkiller viralicidic activity 2-like 2 (EC 3.6.4.13) (ATP-dependent helicase SKIV2L2) Skiv2l2 Mus musculus (Mouse) TR42143_c0_g3_i2 P42285 SK2L2_HUMAN 0 GO:0005524; GO:0008026; GO:0071013; GO:0000398; GO:0000460; GO:0003676; GO:0005730 Q99547 "ATP binding; ATP-dependent helicase activity; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; maturation of 5.8S rRNA; nucleic acid binding; nucleolus" IPR011545; IPR012961; IPR014001; IPR001650; IPR027417; IPR016438; IPR025696; Superkiller viralicidic activity 2-like 2 (EC 3.6.4.13) (ATP-dependent helicase SKIV2L2) SKIV2L2 KIAA0052 Mtr4 Homo sapiens (Human) TR42144_c0_g1_i1 O75351 VPS4B_HUMAN 0 GO:0005524; GO:0042623; GO:0007049; GO:0051301; GO:0005829; GO:0005769; GO:0010008; GO:0007032; GO:0032510; GO:0032367; GO:0005770; GO:0031902; GO:0005764; GO:0005634; GO:0006813; GO:0015031; GO:0033993; GO:0005774; GO:0016032 "ATP binding; ATPase activity, coupled; cell cycle; cell division; cytosol; early endosome; endosome membrane; endosome organization; endosome to lysosome transport via multivesicular body sorting pathway; intracellular cholesterol transport; late endosome; late endosome membrane; lysosome; nucleus; potassium ion transport; protein transport; response to lipid; vacuolar membrane; viral process" IPR003593; IPR003959; IPR003960; IPR007330; IPR027417; IPR015415; Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1) VPS4B SKD1 VPS42 MIG1 Homo sapiens (Human) TR42144_c0_g1_i2 Q5ZJH6 ULK3_CHICK 8.00E-09 GO:0005524; GO:0006914; GO:0005737; GO:0045879; GO:0045880; GO:0046777; GO:0004674 ATP binding; autophagy; cytoplasm; negative regulation of smoothened signaling pathway; positive regulation of smoothened signaling pathway; protein autophosphorylation; protein serine/threonine kinase activity IPR011009; IPR007330; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) ULK3 RCJMB04_18b17 Gallus gallus (Chicken) TR42145_c3_g3_i1 Q9UA35 S28A3_EPTST 2.00E-106 GO:0016021; GO:0005415 integral to membrane; nucleoside:sodium symporter activity IPR008276; IPR018270; IPR011657; IPR002668; Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT) SLC28A3 CNT3 Eptatretus stoutii (Pacific hagfish) TR42146_c0_g1_i2 Q05024 TRI1_YEAST 6.00E-14 GO:0003677; GO:0005737; GO:0005730; GO:0006355; GO:0006351 "DNA binding; cytoplasm; nucleolus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR014876; IPR009057; IPR019835; IPR003121; Protein TRI1 TRI1 YMR233W YM9959.15 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42146_c0_g1_i4 Q05024 TRI1_YEAST 5.00E-14 GO:0003677; GO:0005737; GO:0005730; GO:0006355; GO:0006351 "DNA binding; cytoplasm; nucleolus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR014876; IPR009057; IPR019835; IPR003121; Protein TRI1 TRI1 YMR233W YM9959.15 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42147_c0_g1_i1 Q9NQ36 SCUB2_HUMAN 4.00E-06 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR026823; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR011641; "Signal peptide, CUB and EGF-like domain-containing protein 2 (Protein CEGP1)" SCUBE2 CEGP1 Homo sapiens (Human) TR42147_c2_g2_i1 Q9JJS0 SCUB2_MOUSE 1.00E-12 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR011641; "Signal peptide, CUB and EGF-like domain-containing protein 2 (Protein CEGP1)" Scube2 Cegp1 Mus musculus (Mouse) TR42147_c2_g2_i3 Q6NZL8 SCUB1_MOUSE 6.00E-15 GO:0005509; GO:0009897; GO:0005615; GO:0019897; GO:0046982; GO:0051260 calcium ion binding; external side of plasma membrane; extracellular space; extrinsic to plasma membrane; protein heterodimerization activity; protein homooligomerization IPR026823; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR009030; IPR011641; "Signal peptide, CUB and EGF-like domain-containing protein 1" Scube1 Mus musculus (Mouse) TR42148_c0_g1_i1 P42260 GRIK2_RAT 1.00E-120 GO:0030054; GO:0032839; GO:0005234; GO:0008328; GO:0015277; GO:0051967; GO:0051402; GO:0043204; GO:0043525; GO:0045211; GO:0042803; GO:0043113; GO:0046328; GO:0007268; GO:0043195 Q66HA1 "cell junction; dendrite cytoplasm; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor complex; kainate selective glutamate receptor activity; negative regulation of synaptic transmission, glutamatergic; neuron apoptotic process; perikaryon; positive regulation of neuron apoptotic process; postsynaptic membrane; protein homodimerization activity; receptor clustering; regulation of JNK cascade; synaptic transmission; terminal bouton" IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; "Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6)" Grik2 Glur6 Rattus norvegicus (Rat) TR42148_c0_g1_i3 P42262 GRIA2_HUMAN 2.00E-92 GO:0004971; GO:0032281; GO:0030054; GO:0030666; GO:0005789; GO:0005234; GO:0015277; GO:0045211; GO:0007268; GO:0008021 P46459 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; cell junction; endocytic vesicle membrane; endoplasmic reticulum membrane; extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity; postsynaptic membrane; synaptic transmission; synaptic vesicle IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; "Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (GluA2)" GRIA2 GLUR2 Homo sapiens (Human) TR42148_c0_g1_i4 P42260 GRIK2_RAT 5.00E-121 GO:0030054; GO:0032839; GO:0005234; GO:0008328; GO:0015277; GO:0051967; GO:0051402; GO:0043204; GO:0043525; GO:0045211; GO:0042803; GO:0043113; GO:0046328; GO:0007268; GO:0043195 Q66HA1 "cell junction; dendrite cytoplasm; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor complex; kainate selective glutamate receptor activity; negative regulation of synaptic transmission, glutamatergic; neuron apoptotic process; perikaryon; positive regulation of neuron apoptotic process; postsynaptic membrane; protein homodimerization activity; receptor clustering; regulation of JNK cascade; synaptic transmission; terminal bouton" IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; "Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6)" Grik2 Glur6 Rattus norvegicus (Rat) TR42148_c0_g2_i1 Q60934 GRIK1_MOUSE 9.00E-100 GO:0030534; GO:0048266; GO:0030054; GO:0030425; GO:0005234; GO:0015277; GO:0032983; GO:0051967; GO:0014054; GO:0032230; GO:0045211; GO:0042734; GO:0060079; GO:0060080; GO:0048169; GO:0048172; GO:0035249 "adult behavior; behavioral response to pain; cell junction; dendrite; extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity; kainate selective glutamate receptor complex; negative regulation of synaptic transmission, glutamatergic; positive regulation of gamma-aminobutyric acid secretion; positive regulation of synaptic transmission, GABAergic; postsynaptic membrane; presynaptic membrane; regulation of excitatory postsynaptic membrane potential; regulation of inhibitory postsynaptic membrane potential; regulation of long-term neuronal synaptic plasticity; regulation of short-term neuronal synaptic plasticity; synaptic transmission, glutamatergic" IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; "Glutamate receptor ionotropic, kainate 1 (GluK1) (Glutamate receptor 5) (GluR-5) (GluR5)" Grik1 Glur5 Mus musculus (Mouse) TR42148_c0_g2_i2 Q03445 GLK1_DROME 6.00E-34 GO:0004971; GO:0006812; GO:0030054; GO:0005234; GO:0008328; GO:0045211 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; cation transport; cell junction; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor complex; postsynaptic membrane IPR001828; IPR019594; IPR001320; IPR028082; Glutamate receptor 1 (Glutamate receptor I) (dGLUR-I) (Kainate-selective glutamate receptor) Glu-RI CG8442 Drosophila melanogaster (Fruit fly) TR42148_c0_g2_i6 Q38PU3 GRIK2_MACFA 2.00E-102 GO:0030424; GO:0030054; GO:0043197; GO:0005234; GO:0016021; GO:0004970; GO:0035235; GO:0045211 axon; cell junction; dendritic spine; extracellular-glutamate-gated ion channel activity; integral to membrane; ionotropic glutamate receptor activity; ionotropic glutamate receptor signaling pathway; postsynaptic membrane IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; "Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6)" GRIK2 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR42148_c0_g2_i7 O43424 GRID2_HUMAN 3.00E-23 GO:0030165; GO:0030054; GO:0034613; GO:0043197; GO:0005234; GO:0008066; GO:0004970; GO:0008328; GO:0035235; GO:0045211; GO:0060134; GO:0060079; GO:0043523; GO:0010975; GO:0097110; GO:0045202; GO:0035249; GO:0006810 "PDZ domain binding; cell junction; cellular protein localization; dendritic spine; extracellular-glutamate-gated ion channel activity; glutamate receptor activity; ionotropic glutamate receptor activity; ionotropic glutamate receptor complex; ionotropic glutamate receptor signaling pathway; postsynaptic membrane; prepulse inhibition; regulation of excitatory postsynaptic membrane potential; regulation of neuron apoptotic process; regulation of neuron projection development; scaffold protein binding; synapse; synaptic transmission, glutamatergic; transport" IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; IPR001638; "Glutamate receptor ionotropic, delta-2 (GluD2) (GluR delta-2 subunit)" GRID2 GLURD2 Homo sapiens (Human) TR42148_c0_g2_i9 Q38PU3 GRIK2_MACFA 4.00E-102 GO:0030424; GO:0030054; GO:0043197; GO:0005234; GO:0016021; GO:0004970; GO:0035235; GO:0045211 axon; cell junction; dendritic spine; extracellular-glutamate-gated ion channel activity; integral to membrane; ionotropic glutamate receptor activity; ionotropic glutamate receptor signaling pathway; postsynaptic membrane IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; "Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6)" GRIK2 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR42151_c1_g2_i1 P21328 RTJK_DROME 9.00E-45 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) TR42151_c1_g2_i2 Q03270 PO12_NASVI 9.00E-09 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis IPR000477; Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 2 (Retrovirus-related Pol polyprotein from type I retrotransposable element R1 2) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] (Fragment) Nasonia vitripennis (Parasitic wasp) TR42151_c1_g2_i3 P21328 RTJK_DROME 4.00E-32 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) TR42153_c0_g1_i1 O94527 YBU3_SCHPO 9.00E-21 GO:0005829; GO:0043234 cytosol; protein complex IPR015943; IPR001680; IPR019775; IPR017986; WD repeat protein iqw1 iqw1 SPBC609.03 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42153_c0_g1_i2 Q5TAQ9 DCAF8_HUMAN 2.00E-180 GO:0080008; GO:0016567 P52294; Q99750; Q99873; O43463; P12520 Cul4-RING ubiquitin ligase complex; protein ubiquitination IPR015943; IPR001680; IPR017986; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A) DCAF8 H326 WDR42A Homo sapiens (Human) TR42153_c0_g1_i5 Q5TAQ9 DCAF8_HUMAN 9.00E-175 GO:0080008; GO:0016567 P52294; Q99750; Q99873; O43463; P12520 Cul4-RING ubiquitin ligase complex; protein ubiquitination IPR015943; IPR001680; IPR017986; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A) DCAF8 H326 WDR42A Homo sapiens (Human) TR42154_c1_g2_i1 O55035 PPIG_RAT 1.00E-67 GO:0016363; GO:0016607; GO:0003755; GO:0006457 nuclear matrix; nuclear speck; peptidyl-prolyl cis-trans isomerase activity; protein folding IPR002130; IPR020892; Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (Cyclophilin G) (Matrin cyclophilin) (Matrin-cyp) (Rotamase G) Ppig Rattus norvegicus (Rat) TR42154_c1_g2_i2 O55035 PPIG_RAT 6.00E-68 GO:0016363; GO:0016607; GO:0003755; GO:0006457 nuclear matrix; nuclear speck; peptidyl-prolyl cis-trans isomerase activity; protein folding IPR002130; IPR020892; Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (Cyclophilin G) (Matrin cyclophilin) (Matrin-cyp) (Rotamase G) Ppig Rattus norvegicus (Rat) TR42154_c1_g2_i3 Q9D6D8 PPIL6_MOUSE 5.00E-19 GO:0003755; GO:0006457; GO:0000413 peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; Peptidyl-prolyl cis-trans isomerase-like 6 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL6) (Rotamase PPIL6) Ppil6 Mus musculus (Mouse) TR42155_c0_g1_i2 Q6NTN5 MTMRD_XENLA 7.00E-07 GO:0005737; GO:0005085; GO:0016020; GO:0016791; GO:0005543 cytoplasm; guanyl-nucleotide exchange factor activity; membrane; phosphatase activity; phospholipid binding IPR005112; IPR001194; IPR004182; IPR010569; IPR017906; IPR011993; IPR001849; IPR022096; IPR005113; Myotubularin-related protein 13 (SET-binding factor 2) sbf2 mtmr13 Xenopus laevis (African clawed frog) TR42155_c0_g2_i1 O95248 MTMR5_HUMAN 6.00E-91 GO:0017112; GO:0008219; GO:0016021; GO:0005634; GO:0005543; GO:0006470; GO:0008138; GO:0007283 Rab guanyl-nucleotide exchange factor activity; cell death; integral to membrane; nucleus; phospholipid binding; protein dephosphorylation; protein tyrosine/serine/threonine phosphatase activity; spermatogenesis IPR005112; IPR001194; IPR004182; IPR010569; IPR017906; IPR011993; IPR001849; IPR022096; IPR005113; Myotubularin-related protein 5 (SET-binding factor 1) (Sbf1) SBF1 MTMR5 Homo sapiens (Human) TR42155_c0_g2_i2 O13819 YMR1_SCHPO 4.00E-23 GO:0005829; GO:0048017; GO:0035335; GO:0046856; GO:0004438; GO:0004725; GO:0016192 cytosol; inositol lipid-mediated signaling; peptidyl-tyrosine dephosphorylation; phosphatidylinositol dephosphorylation; phosphatidylinositol-3-phosphatase activity; protein tyrosine phosphatase activity; vesicle-mediated transport IPR010569; IPR017906; IPR011993; IPR016130; Phosphoinositide 3-phosphatase (EC 3.1.3.64) SPAC19A8.03 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42156_c0_g1_i1 Q28XE2 AN32A_DROPS 4.00E-59 GO:0005783; GO:0006913; GO:0005634; GO:0048471 endoplasmic reticulum; nucleocytoplasmic transport; nucleus; perinuclear region of cytoplasm IPR001611; IPR003603; Acidic leucine-rich nuclear phosphoprotein 32 family member A Anp32a Mapmodulin GA19125 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR42156_c1_g2_i1 Q8R3P7 CLUA1_MOUSE 3.00E-142 GO:0030030; GO:0005929; GO:0005634 cell projection organization; cilium; nucleus IPR019366; Clusterin-associated protein 1 Cluap1 Mus musculus (Mouse) TR42157_c3_g1_i1 Q9NDJ2 DOM_DROME 8.00E-101 GO:0005524; GO:0003677; GO:0008094; GO:0035267; GO:0007049; GO:0070983; GO:0016458; GO:0004386; GO:0030097; GO:0016573; GO:0043486; GO:0002165; GO:0035207; GO:0048477; GO:0045747; GO:2000637; GO:0000381; GO:0006355; GO:0006351; GO:0035222 "ATP binding; DNA binding; DNA-dependent ATPase activity; NuA4 histone acetyltransferase complex; cell cycle; dendrite guidance; gene silencing; helicase activity; hemopoiesis; histone acetylation; histone exchange; instar larval or pupal development; negative regulation of hemocyte proliferation; oogenesis; positive regulation of Notch signaling pathway; positive regulation of gene silencing by miRNA; regulation of alternative mRNA splicing, via spliceosome; regulation of transcription, DNA-dependent; transcription, DNA-dependent; wing disc pattern formation" IPR013999; IPR014012; IPR014001; IPR001650; IPR017877; IPR027417; IPR000330; Helicase domino (EC 3.6.4.-) dom CG9696 Drosophila melanogaster (Fruit fly) TR42157_c3_g1_i2 Q8CHI8 EP400_MOUSE 4.00E-95 GO:0005524; GO:0003677; GO:0035267; GO:0003682; GO:0004386; GO:0043968; GO:0043967; GO:0016607 ATP binding; DNA binding; NuA4 histone acetyltransferase complex; chromatin binding; helicase activity; histone H2A acetylation; histone H4 acetylation; nuclear speck IPR013999; IPR014012; IPR014001; IPR001650; IPR017877; IPR027417; IPR001005; IPR000330; E1A-binding protein p400 (EC 3.6.4.-) (Domino homolog) (mDomino) (p400 kDa SWI2/SNF2-related protein) Ep400 Kiaa1498 Mus musculus (Mouse) TR42157_c3_g1_i4 Q9NDJ2 DOM_DROME 6.00E-139 GO:0005524; GO:0003677; GO:0008094; GO:0035267; GO:0007049; GO:0070983; GO:0016458; GO:0004386; GO:0030097; GO:0016573; GO:0043486; GO:0002165; GO:0035207; GO:0048477; GO:0045747; GO:2000637; GO:0000381; GO:0006355; GO:0006351; GO:0035222 "ATP binding; DNA binding; DNA-dependent ATPase activity; NuA4 histone acetyltransferase complex; cell cycle; dendrite guidance; gene silencing; helicase activity; hemopoiesis; histone acetylation; histone exchange; instar larval or pupal development; negative regulation of hemocyte proliferation; oogenesis; positive regulation of Notch signaling pathway; positive regulation of gene silencing by miRNA; regulation of alternative mRNA splicing, via spliceosome; regulation of transcription, DNA-dependent; transcription, DNA-dependent; wing disc pattern formation" IPR013999; IPR014012; IPR014001; IPR001650; IPR017877; IPR027417; IPR000330; Helicase domino (EC 3.6.4.-) dom CG9696 Drosophila melanogaster (Fruit fly) TR42157_c3_g2_i1 Q9QZM5 ABI1_RAT 2.00E-54 GO:0030054; GO:0006928; GO:0005737; GO:0005856; GO:0030175; GO:0030426; GO:0030027; GO:0072673; GO:0035855; GO:0005634; GO:0018108; GO:0030296; GO:0001756; GO:0045202 P52164; Q9JLU4 cell junction; cellular component movement; cytoplasm; cytoskeleton; filopodium; growth cone; lamellipodium; lamellipodium morphogenesis; megakaryocyte development; nucleus; peptidyl-tyrosine phosphorylation; protein tyrosine kinase activator activity; somitogenesis; synapse IPR012849; IPR000108; IPR001452; IPR000727; Abl interactor 1 (Abelson interactor 1) (Abi-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) Abi1 Rattus norvegicus (Rat) TR42157_c3_g2_i4 Q14155 ARHG7_HUMAN 8.00E-07 GO:0005089; GO:0097190; GO:0005938; GO:0005829; GO:0007173; GO:0005925; GO:0005085; GO:0030027; GO:0030032; GO:0042059; GO:0007399; GO:0043005; GO:0043025; GO:0048011; GO:0005543; GO:0043547; GO:0043065; GO:0043234; GO:0035023; GO:0051056; GO:0001726; GO:0007264 P22681; Q9Y2X7; Q5S007; P41227; Q13153; Q13177; P63000; Q14160; O60880 Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; cell cortex; cytosol; epidermal growth factor receptor signaling pathway; focal adhesion; guanyl-nucleotide exchange factor activity; lamellipodium; lamellipodium assembly; negative regulation of epidermal growth factor receptor signaling pathway; nervous system development; neuron projection; neuronal cell body; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of GTPase activity; positive regulation of apoptotic process; protein complex; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; ruffle; small GTPase mediated signal transduction IPR001715; IPR000219; IPR001331; IPR011993; IPR001849; IPR011511; IPR001452; Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314 Homo sapiens (Human) TR42157_c3_g2_i6 Q9QZM5 ABI1_RAT 3.00E-56 GO:0030054; GO:0006928; GO:0005737; GO:0005856; GO:0030175; GO:0030426; GO:0030027; GO:0072673; GO:0035855; GO:0005634; GO:0018108; GO:0030296; GO:0001756; GO:0045202 P52164; Q9JLU4 cell junction; cellular component movement; cytoplasm; cytoskeleton; filopodium; growth cone; lamellipodium; lamellipodium morphogenesis; megakaryocyte development; nucleus; peptidyl-tyrosine phosphorylation; protein tyrosine kinase activator activity; somitogenesis; synapse IPR012849; IPR000108; IPR001452; IPR000727; Abl interactor 1 (Abelson interactor 1) (Abi-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) Abi1 Rattus norvegicus (Rat) TR42157_c3_g2_i7 Q9P2A4 ABI3_HUMAN 2.00E-37 GO:0006928; GO:0005737; GO:0030027; GO:0030334 O15372 cellular component movement; cytoplasm; lamellipodium; regulation of cell migration IPR012849; IPR001452; ABI gene family member 3 (New molecule including SH3) (Nesh) ABI3 NESH Homo sapiens (Human) TR42158_c1_g1_i1 Q9P0L1 ZN167_HUMAN 1.00E-42 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein with KRAB and SCAN domains 7 (Zinc finger protein 167) (Zinc finger protein 448) (Zinc finger protein 64) ZKSCAN7 ZNF167 ZNF448 ZNF64 Homo sapiens (Human) TR42158_c1_g2_i1 Q7TNK3 ZNF24_RAT 3.00E-25 GO:0046872; GO:0042552; GO:0045892; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "metal ion binding; myelination; negative regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein 24 (Zinc finger protein 191) (Zfp-191) Znf24 Zfp191 Znf191 Rattus norvegicus (Rat) TR42158_c1_g3_i1 P17022 ZNF18_HUMAN 9.00E-30 GO:0003677; GO:0046872; GO:0005634; GO:0000981 DNA binding; metal ion binding; nucleus; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR001909; IPR008916; IPR003309; IPR027764; IPR007087; IPR015880; IPR013087; Zinc finger protein 18 (Heart development-specific gene 1 protein) (Zinc finger protein 535) (Zinc finger protein KOX11) (Zinc finger protein with KRAB and SCAN domains 6) ZNF18 HDSG1 KOX11 ZKSCAN6 ZNF535 Homo sapiens (Human) TR42158_c2_g1_i3 Q7Z7L9 ZSCA2_HUMAN 9.00E-11 GO:0003677; GO:0030154; GO:0046872; GO:0007275; GO:0005634; GO:0003700; GO:0007283; GO:0006351 "DNA binding; cell differentiation; metal ion binding; multicellular organismal development; nucleus; sequence-specific DNA binding transcription factor activity; spermatogenesis; transcription, DNA-dependent" IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) ZSCAN2 ZFP29 ZNF854 Homo sapiens (Human) TR42158_c2_g1_i5 Q60542 ZEB1_MESAU 2.00E-13 GO:0070888; GO:0046872; GO:0045892; GO:0005634; GO:0045666; GO:0043565; GO:0003700; GO:0006351 "E-box binding; metal ion binding; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of neuron differentiation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR008598; IPR001356; IPR009057; IPR007087; IPR015880; IPR013087; Zinc finger E-box-binding homeobox 1 (Transcription factor 8) (TCF-8) (Zinc finger protein BZP) ZEB1 BZP TCF8 Mesocricetus auratus (Golden hamster) TR42158_c2_g1_i6 Q13360 ZN177_HUMAN 2.00E-09 GO:0003677; GO:0046872; GO:0000122; GO:0005634; GO:0006351 "DNA binding; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 177 ZNF177 Homo sapiens (Human) TR42158_c2_g1_i7 O43361 ZN749_HUMAN 4.00E-06 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 749 ZNF749 Homo sapiens (Human) TR42158_c2_g1_i8 Q9UDV7 ZN282_HUMAN 4.00E-12 GO:0003677; GO:0045892; GO:0005634; GO:0006351; GO:0008270 "DNA binding; negative regulation of transcription, DNA-dependent; nucleus; transcription, DNA-dependent; zinc ion binding" IPR022137; IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1) ZNF282 HUB1 Homo sapiens (Human) TR42159_c0_g1_i10 Q550L8 IFKB_DICDI 2.00E-19 GO:0005524; GO:0016337; GO:0031589; GO:0004694; GO:0005622 ATP binding; cell-cell adhesion; cell-substrate adhesion; eukaryotic translation initiation factor 2alpha kinase activity; intracellular IPR004154; IPR024435; IPR011009; IPR000719; IPR017441; IPR008271; Probable serine/threonine-protein kinase ifkB (EC 2.7.11.1) (Initiation factor kinase B) ifkB DDB_G0276829 Dictyostelium discoideum (Slime mold) TR42159_c0_g1_i2 P19525 E2AK2_HUMAN 1.00E-20 GO:0005524; GO:0000186; GO:0005829; GO:0051607; GO:0003725; GO:0030968; GO:0004694; GO:0030683; GO:0045087; GO:0019054; GO:0033689; GO:0017148; GO:0045071; GO:0004715; GO:0005634; GO:0018108; GO:0048471; GO:0051092; GO:1901224; GO:0032722; GO:0032874; GO:0046777; GO:0008601; GO:1900225; GO:1901532; GO:1902036; GO:1902033; GO:0035455; GO:0009615; GO:0006351; GO:0006412; GO:0019058; GO:0006926 O92972; P27958; P06493; Q7L2E3; Q96C10; Q08211; Q9UPY3; Q27968; Q6P2E9; P05198; P56537; Q8IY81; P20639; Q9HCE1; P06748; Q9NUL3; Q15633; Q9H0E2; P04487; Q9UL40 "ATP binding; activation of MAPKK activity; cytosol; defense response to virus; double-stranded RNA binding; endoplasmic reticulum unfolded protein response; eukaryotic translation initiation factor 2alpha kinase activity; evasion or tolerance by virus of host immune response; innate immune response; modulation by virus of host process; negative regulation of osteoblast proliferation; negative regulation of translation; negative regulation of viral genome replication; non-membrane spanning protein tyrosine kinase activity; nucleus; peptidyl-tyrosine phosphorylation; perinuclear region of cytoplasm; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB cascade; positive regulation of chemokine production; positive regulation of stress-activated MAPK cascade; protein autophosphorylation; protein phosphatase type 2A regulator activity; regulation of NLRP3 inflammasome complex assembly; regulation of hematopoietic progenitor cell differentiation; regulation of hematopoietic stem cell differentiation; regulation of hematopoietic stem cell proliferation; response to interferon-alpha; response to virus; transcription, DNA-dependent; translation; viral life cycle; virus-infected cell apoptotic process" IPR014720; IPR011009; IPR000719; IPR017441; IPR008271; "Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)" EIF2AK2 PKR PRKR Homo sapiens (Human) TR42159_c0_g1_i3 Q9HGN1 GCN2_SCHPO 2.00E-29 GO:0005524; GO:0002183; GO:0004694; GO:0007093; GO:0071263; GO:0043561 ATP binding; cytoplasmic translational initiation; eukaryotic translation initiation factor 2alpha kinase activity; mitotic cell cycle checkpoint; negative regulation of translational initiation in response to starvation; regulation of translational initiation in response to osmotic stress IPR024435; IPR011009; IPR000719; IPR017441; IPR006575; IPR008271; IPR016255; IPR016135; Serine/threonine-protein kinase gcn2 (EC 2.7.11.1) (Serine/threonine-protein kinase ppk28) gcn2 ppk28 SPBC36B7.09 SPBP18G5.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42159_c0_g1_i5 Q8C0X8 SMKX_MOUSE 4.00E-16 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Sperm motility kinase X (EC 2.7.11.1) Mus musculus (Mouse) TR42159_c0_g1_i6 Q9LX30 GCN2_ARATH 9.00E-33 GO:0005524; GO:0004812; GO:0008652; GO:0018108; GO:0004674; GO:0004713; GO:0006412 ATP binding; aminoacyl-tRNA ligase activity; cellular amino acid biosynthetic process; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; translation IPR004154; IPR024435; IPR011009; IPR000719; IPR017441; IPR006575; IPR008266; IPR016135; Probable serine/threonine-protein kinase GCN2 (EC 2.7.11.1) GCN2 At3g59410 F25L23_270 Arabidopsis thaliana (Mouse-ear cress) TR42159_c0_g1_i7 Q9Z2R9 E2AK1_MOUSE 3.00E-23 GO:0005524; GO:0005737; GO:0004694; GO:0020037; GO:0008285; GO:0046986; GO:0017148; GO:0046777; GO:0046501; GO:0010999; GO:0006417; GO:0009605; GO:0006950 Q6ZWX6 ATP binding; cytoplasm; eukaryotic translation initiation factor 2alpha kinase activity; heme binding; negative regulation of cell proliferation; negative regulation of hemoglobin biosynthetic process; negative regulation of translation; protein autophosphorylation; protoporphyrinogen IX metabolic process; regulation of eIF2 alpha phosphorylation by heme; regulation of translation; response to external stimulus; response to stress IPR011009; IPR000719; IPR017441; IPR008271; Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Hemin-sensitive initiation factor 2-alpha kinase) Eif2ak1 Hri Mus musculus (Mouse) TR42159_c0_g1_i8 Q9HGN1 GCN2_SCHPO 5.00E-29 GO:0005524; GO:0002183; GO:0004694; GO:0007093; GO:0071263; GO:0043561 ATP binding; cytoplasmic translational initiation; eukaryotic translation initiation factor 2alpha kinase activity; mitotic cell cycle checkpoint; negative regulation of translational initiation in response to starvation; regulation of translational initiation in response to osmotic stress IPR024435; IPR011009; IPR000719; IPR017441; IPR006575; IPR008271; IPR016255; IPR016135; Serine/threonine-protein kinase gcn2 (EC 2.7.11.1) (Serine/threonine-protein kinase ppk28) gcn2 ppk28 SPBC36B7.09 SPBP18G5.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42159_c0_g1_i9 Q9P2K8 E2AK4_HUMAN 1.00E-23 GO:0005524; GO:0009267; GO:0022626; GO:0030968; GO:0004694; GO:0017148; GO:0006446; GO:0043558 ATP binding; cellular response to starvation; cytosolic ribosome; endoplasmic reticulum unfolded protein response; eukaryotic translation initiation factor 2alpha kinase activity; negative regulation of translation; regulation of translational initiation; regulation of translational initiation in response to stress IPR004154; IPR024435; IPR011009; IPR000719; IPR017441; IPR006575; IPR008271; IPR016255; IPR016135; Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) EIF2AK4 GCN2 KIAA1338 Homo sapiens (Human) TR42160_c0_g1_i2 Q15652 JHD2C_HUMAN 1.00E-114 GO:0007596; GO:0016568; GO:0051213; GO:0046872; GO:0005654; GO:0006355; GO:0046966; GO:0006351 P10275 "blood coagulation; chromatin modification; dioxygenase activity; metal ion binding; nucleoplasm; regulation of transcription, DNA-dependent; thyroid hormone receptor binding; transcription, DNA-dependent" IPR003347; Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) JMJD1C JHDM2C KIAA1380 TRIP8 Homo sapiens (Human) TR42160_c0_g1_i4 Q15652 JHD2C_HUMAN 1.00E-114 GO:0007596; GO:0016568; GO:0051213; GO:0046872; GO:0005654; GO:0006355; GO:0046966; GO:0006351 P10275 "blood coagulation; chromatin modification; dioxygenase activity; metal ion binding; nucleoplasm; regulation of transcription, DNA-dependent; thyroid hormone receptor binding; transcription, DNA-dependent" IPR003347; Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) JMJD1C JHDM2C KIAA1380 TRIP8 Homo sapiens (Human) TR42160_c0_g2_i1 Q7LBC6 KDM3B_HUMAN 6.00E-86 GO:0016568; GO:0051213; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "chromatin modification; dioxygenase activity; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR003347; Lysine-specific demethylase 3B (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) KDM3B C5orf7 JHDM2B JMJD1B KIAA1082 Homo sapiens (Human) TR42162_c1_g2_i1 Q99126 CHS3_USTMA 6.00E-16 GO:0006031; GO:0004100; GO:0030659; GO:0016021; GO:0005886 chitin biosynthetic process; chitin synthase activity; cytoplasmic vesicle membrane; integral to membrane; plasma membrane IPR004834; IPR013616; Chitin synthase 3 (EC 2.4.1.16) (Chitin synthase I) (Chitin-UDP acetyl-glucosaminyl transferase 3) CHS3 CHS1 UM00474 UM10120 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR42162_c1_g2_i3 Q99126 CHS3_USTMA 6.00E-16 GO:0006031; GO:0004100; GO:0030659; GO:0016021; GO:0005886 chitin biosynthetic process; chitin synthase activity; cytoplasmic vesicle membrane; integral to membrane; plasma membrane IPR004834; IPR013616; Chitin synthase 3 (EC 2.4.1.16) (Chitin synthase I) (Chitin-UDP acetyl-glucosaminyl transferase 3) CHS3 CHS1 UM00474 UM10120 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR42165_c0_g1_i1 Q96QG7 MTMR9_HUMAN 6.00E-26 GO:0005737; GO:0030234; GO:0016791 cytoplasm; enzyme regulator activity; phosphatase activity IPR010569; IPR017906; IPR011993; Myotubularin-related protein 9 MTMR9 C8orf9 MTMR8 Homo sapiens (Human) TR42165_c0_g4_i1 Q9Z2D0 MTMR9_MOUSE 2.00E-162 GO:0005737; GO:0030234; GO:0016791 cytoplasm; enzyme regulator activity; phosphatase activity IPR010569; IPR017906; IPR011993; Myotubularin-related protein 9 Mtmr9 Mtmr3 Mus musculus (Mouse) TR42173_c1_g2_i1 P51128 RXRA_XENLA 1.00E-70 GO:0005634; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR021780; IPR008946; IPR000536; IPR000003; IPR001723; IPR001628; IPR013088; Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha) rxra nr2b1 Xenopus laevis (African clawed frog) TR42175_c1_g3_i4 Q90577 SRCA_CHICK 1.00E-08 GO:0005525; GO:0006184; GO:0003924; GO:0033018 GTP binding; GTP catabolic process; GTPase activity; sarcoplasmic reticulum lumen IPR001401; IPR027417; Sarcalumenin SRL Gallus gallus (Chicken) TR42176_c1_g2_i1 Q6DKE0 DHDH_XENLA 1.00E-83 GO:0047837; GO:0047115 "D-xylose 1-dehydrogenase (NADP+) activity; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity" IPR016040; IPR000683; "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) (D-xylose 1-dehydrogenase) (D-xylose-NADP dehydrogenase) (EC 1.1.1.179) (Dimeric dihydrodiol dehydrogenase)" dhdh Xenopus laevis (African clawed frog) TR42176_c1_g2_i2 Q9SZ83 Y4967_ARATH 2.00E-14 GO:0005829; GO:0016491 cytosol; oxidoreductase activity IPR016040; IPR000683; IPR004104; Uncharacterized oxidoreductase At4g09670 (EC 1.-.-.-) At4g09670 F17A8.20 Arabidopsis thaliana (Mouse-ear cress) TR42176_c1_g2_i3 Q642M9 DHDH_DANRE 2.00E-82 GO:0047837; GO:0047115 "D-xylose 1-dehydrogenase (NADP+) activity; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity" IPR016040; IPR000683; IPR004104; "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) (D-xylose 1-dehydrogenase) (D-xylose-NADP dehydrogenase) (EC 1.1.1.179) (Dimeric dihydrodiol dehydrogenase)" dhdh ch211-203b17.3 zgc:101723 Danio rerio (Zebrafish) (Brachydanio rerio) TR42176_c1_g2_i4 Q148L6 DHDH_BOVIN 1.00E-70 GO:0047837; GO:0042843; GO:0047115 "D-xylose 1-dehydrogenase (NADP+) activity; D-xylose catabolic process; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity" IPR016040; IPR000683; IPR004104; "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) (D-xylose 1-dehydrogenase) (D-xylose-NADP dehydrogenase) (EC 1.1.1.179) (Dimeric dihydrodiol dehydrogenase)" DHDH Bos taurus (Bovine) TR42176_c1_g2_i5 Q6DKE0 DHDH_XENLA 2.00E-88 GO:0047837; GO:0047115 "D-xylose 1-dehydrogenase (NADP+) activity; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity" IPR016040; IPR000683; "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) (D-xylose 1-dehydrogenase) (D-xylose-NADP dehydrogenase) (EC 1.1.1.179) (Dimeric dihydrodiol dehydrogenase)" dhdh Xenopus laevis (African clawed frog) TR42176_c1_g2_i6 A1JSK7 IOLG_YERE8 8.00E-10 GO:0050112; GO:0019310 inositol 2-dehydrogenase activity; inositol catabolic process IPR023794; IPR016040; IPR000683; IPR004104; Inositol 2-dehydrogenase (EC 1.1.1.18) (Myo-inositol 2-dehydrogenase) (MI 2-dehydrogenase) iolG YE4026 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) TR42176_c1_g2_i7 Q642M9 DHDH_DANRE 1.00E-81 GO:0047837; GO:0047115 "D-xylose 1-dehydrogenase (NADP+) activity; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity" IPR016040; IPR000683; IPR004104; "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) (D-xylose 1-dehydrogenase) (D-xylose-NADP dehydrogenase) (EC 1.1.1.179) (Dimeric dihydrodiol dehydrogenase)" dhdh ch211-203b17.3 zgc:101723 Danio rerio (Zebrafish) (Brachydanio rerio) TR42177_c3_g1_i1 Q8DI58 DNAK2_THEEB 1.00E-06 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein dnaK2 (HSP70-2) (Heat shock 70 kDa protein 2) (Heat shock protein 70-2) dnaK2 tlr1733 Thermosynechococcus elongatus (strain BP-1) TR42177_c3_g1_i3 Q6MB26 DNAK_PARUW 8.00E-08 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK pc1499 Protochlamydia amoebophila (strain UWE25) TR42177_c3_g1_i4 Q96MM6 HS12B_HUMAN 8.00E-64 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR42177_c3_g1_i5 Q12WE6 DNAK_METBU 5.00E-08 GO:0005524; GO:0006457 ATP binding; protein folding IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK Mbur_1312 Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) TR42177_c3_g1_i7 Q96MM6 HS12B_HUMAN 2.00E-68 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR42177_c3_g1_i8 B9KBT4 DNAK_THENN 4.00E-08 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK CTN_0304 Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E) TR42178_c1_g6_i1 Q5BK26 PLPL7_RAT 0 GO:0004091; GO:0005783; GO:0016021; GO:0006629; GO:0005765; GO:0031966; GO:0031965 carboxylesterase activity; endoplasmic reticulum; integral to membrane; lipid metabolic process; lysosomal membrane; mitochondrial membrane; nuclear membrane IPR016035; IPR018490; IPR000595; IPR002641; IPR014710; Patatin-like phospholipase domain-containing protein 7 (EC 3.1.1.-) (Liver NTE-related protein 1) (NTE-related esterase) Pnpla7 Nre Ntel1 Rattus norvegicus (Rat) TR42181_c1_g1_i4 Q9D342 T170A_MOUSE 2.00E-32 GO:0016021 integral to membrane IPR019334; Transmembrane protein 170A Tmem170a D8Bwg1414e Tmem170 Mus musculus (Mouse) TR42181_c1_g1_i9 A3KPL7 T170A_DANRE 2.00E-22 GO:0016021 integral to membrane IPR019334; Transmembrane protein 170A tmem170a tmem170 si:dkey-6e12.5 zgc:66371 Danio rerio (Zebrafish) (Brachydanio rerio) TR42182_c2_g3_i2 Q60899 ELAV2_MOUSE 2.00E-21 GO:0003723; GO:0000166 RNA binding; nucleotide binding IPR006548; IPR002343; IPR012677; IPR000504; ELAV-like protein 2 (ELAV-like neuronal protein 1) (Hu-antigen B) (HuB) (Nervous system-specific RNA-binding protein Mel-N1) Elavl2 Hub Mus musculus (Mouse) TR42182_c2_g3_i3 P52912 TIA1_MOUSE 6.00E-117 GO:0017091; GO:0006915; GO:0010494; GO:0042036; GO:0017148; GO:0000166; GO:0005634; GO:0048024 "AU-rich element binding; apoptotic process; cytoplasmic stress granule; negative regulation of cytokine biosynthetic process; negative regulation of translation; nucleotide binding; nucleus; regulation of mRNA splicing, via spliceosome" IPR012677; IPR000504; Nucleolysin TIA-1 (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1) Tia1 Tia Mus musculus (Mouse) TR42182_c2_g3_i7 Q9LEB3 RBP47_NICPL 2.00E-40 GO:0034605; GO:0010494; GO:0006397; GO:0000166; GO:0005634; GO:0008143 cellular response to heat; cytoplasmic stress granule; mRNA processing; nucleotide binding; nucleus; poly(A) RNA binding IPR012677; IPR000504; Polyadenylate-binding protein RBP47 (Poly(A)-binding protein RBP47) (RNA-binding protein 47) (NplRBP47) RBP47 Nicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco) TR42182_c2_g3_i8 P70372 ELAV1_MOUSE 2.00E-19 GO:0070935; GO:0005737; GO:0003725; GO:0035925; GO:0000166; GO:0005634; GO:0045727 Q03160; Q80ZW7 3'-UTR-mediated mRNA stabilization; cytoplasm; double-stranded RNA binding; mRNA 3'-UTR AU-rich region binding; nucleotide binding; nucleus; positive regulation of translation IPR006548; IPR002343; IPR012677; IPR000504; ELAV-like protein 1 (Elav-like generic protein) (Hu-antigen R) (HuR) (MelG) Elavl1 Elra Hua Mus musculus (Mouse) TR42184_c0_g1_i1 Q80U62 RUBIC_MOUSE 5.00E-41 GO:0005794; GO:0006914; GO:0005769; GO:0006897; GO:0005770; GO:0005764; GO:0010507; GO:0045806 Golgi apparatus; autophagy; early endosome; endocytosis; late endosome; lysosome; negative regulation of autophagy; negative regulation of endocytosis IPR025258; IPR004012; Run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) Kiaa0226 Mus musculus (Mouse) TR42184_c0_g1_i2 Q5PQS0 PKHM1_RAT 1.00E-56 GO:0005737; GO:0035556; GO:0046872; GO:0005543 cytoplasm; intracellular signal transduction; metal ion binding; phospholipid binding IPR025258; IPR011993; IPR001849; IPR002219; IPR004012; Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) Plekhm1 Rattus norvegicus (Rat) TR42184_c0_g1_i4 Q08AW4 PKHM3_XENLA 5.00E-72 GO:0035556; GO:0005543; GO:0008270 intracellular signal transduction; phospholipid binding; zinc ion binding IPR025258; IPR011993; IPR001849; IPR002219; IPR001841; Pleckstrin homology domain-containing family M member 3 (PH domain-containing family M member 3) plekhm3 Xenopus laevis (African clawed frog) TR42184_c0_g1_i5 Q6DJB3 DEFI8_XENTR 6.00E-46 GO:0035556; GO:0008270 intracellular signal transduction; zinc ion binding IPR025258; IPR002219; IPR001841; Differentially expressed in FDCP 8 homolog (DEF-8) def8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42184_c0_g1_i6 Q5PQS0 PKHM1_RAT 2.00E-56 GO:0005737; GO:0035556; GO:0046872; GO:0005543 cytoplasm; intracellular signal transduction; metal ion binding; phospholipid binding IPR025258; IPR011993; IPR001849; IPR002219; IPR004012; Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) Plekhm1 Rattus norvegicus (Rat) TR42184_c0_g1_i7 Q08AW4 PKHM3_XENLA 3.00E-72 GO:0035556; GO:0005543; GO:0008270 intracellular signal transduction; phospholipid binding; zinc ion binding IPR025258; IPR011993; IPR001849; IPR002219; IPR001841; Pleckstrin homology domain-containing family M member 3 (PH domain-containing family M member 3) plekhm3 Xenopus laevis (African clawed frog) TR42187_c0_g1_i2 Q91YE8 SYNP2_MOUSE 1.00E-13 GO:0071889; GO:0030018; GO:0003779; GO:0051371; GO:0005634 P31946; Q9CQV8 14-3-3 protein binding; Z disc; actin binding; muscle alpha-actinin binding; nucleus IPR001478; Synaptopodin-2 (Myopodin) Synpo2 Mus musculus (Mouse) TR42187_c0_g1_i4 Q9H987 SYP2L_HUMAN 2.00E-16 GO:0030018; GO:0005856; GO:0005634 Z disc; cytoskeleton; nucleus IPR001478; Synaptopodin 2-like protein SYNPO2L Homo sapiens (Human) TR42187_c0_g1_i5 A1ZA47 ZASP_DROME 6.00E-07 GO:0030018; GO:0015629; GO:0051371; GO:0005927; GO:0030239; GO:0001952; GO:0008270 Z disc; actin cytoskeleton; muscle alpha-actinin binding; muscle tendon junction; myofibril assembly; regulation of cell-matrix adhesion; zinc ion binding IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) TR42187_c0_g1_i6 Q9H987 SYP2L_HUMAN 2.00E-16 GO:0030018; GO:0005856; GO:0005634 Z disc; cytoskeleton; nucleus IPR001478; Synaptopodin 2-like protein SYNPO2L Homo sapiens (Human) TR42188_c1_g4_i1 Q0WL80 UGGG_ARATH 3.00E-122 GO:0003980; GO:0097359; GO:0005788; GO:0006486 UDP-glucose:glycoprotein glucosyltransferase activity; UDP-glucosylation; endoplasmic reticulum lumen; protein glycosylation IPR002495; IPR009448; Protein modification; protein glycosylation. UDP-glucose:glycoprotein glucosyltransferase (EC 2.4.1.-) (EMS-mutagenized BRI1 suppressor 1) (Protein PRIORITY IN SWEET LIFE 2) UGGT EBS1 PSL2 At1g71220 F3I17.13 Arabidopsis thaliana (Mouse-ear cress) TR42188_c1_g4_i2 Q6P5E4 UGGG1_MOUSE 0 GO:0003980; GO:0005788; GO:0005793; GO:0006486; GO:0051082 UDP-glucose:glycoprotein glucosyltransferase activity; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment; protein glycosylation; unfolded protein binding IPR009448; Protein modification; protein glycosylation. UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1) Uggt1 Gt Ugcgl1 Uggt Ugt1 Ugtr Mus musculus (Mouse) TR42188_c1_g4_i3 Q09332 UGGG_DROME 0 GO:0003980; GO:0005788; GO:0005635; GO:0006486; GO:0005791 UDP-glucose:glycoprotein glucosyltransferase activity; endoplasmic reticulum lumen; nuclear envelope; protein glycosylation; rough endoplasmic reticulum IPR002495; IPR009448; Protein modification; protein glycosylation. UDP-glucose:glycoprotein glucosyltransferase (UGT) (dUGT) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) Ugt UGGG CG6850 Drosophila melanogaster (Fruit fly) TR42188_c1_g4_i7 Q6P5E4 UGGG1_MOUSE 2.00E-62 GO:0003980; GO:0005788; GO:0005793; GO:0006486; GO:0051082 UDP-glucose:glycoprotein glucosyltransferase activity; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment; protein glycosylation; unfolded protein binding IPR009448; Protein modification; protein glycosylation. UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1) Uggt1 Gt Ugcgl1 Uggt Ugt1 Ugtr Mus musculus (Mouse) TR42189_c0_g2_i1 A6MFL3 IVBI3_DEMVE 3.00E-13 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Protease inhibitor vestiginin-3 Demansia vestigiata (Lesser black whip snake) (Demansia atra) TR42189_c0_g2_i2 Q6T269 IVBI3_BITGA 7.00E-13 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Protease inhibitor bitisilin-3 (Two-Kunitz protease inhibitor) (Fragment) Bitis gabonica (Gaboon adder) (Gaboon viper) TR42189_c0_g2_i3 D2Y488 CU91A_CONCL 6.00E-12 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; Conotoxin Cal9.1a Conus californicus (California cone) TR42189_c0_g2_i4 B4ESA3 IVB2L_BUNMU 3.00E-12 GO:0005576; GO:0008191; GO:0004867 extracellular region; metalloendopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Protease inhibitor-like protein 2 (PILP-2) Bungarus multicinctus (Many-banded krait) TR4219_c0_g1_i1 Q9D504 ANKR7_MOUSE 7.00E-06 GO:0005634 nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 7 Ankrd7 Mus musculus (Mouse) TR4219_c1_g1_i1 O75762 TRPA1_HUMAN 1.00E-09 GO:0005262; GO:0015267; GO:0050968; GO:0050966; GO:0005887; GO:0006811; GO:0009409; GO:0042493; GO:0042542; GO:0048265; GO:0032421; GO:0050955 calcium channel activity; channel activity; detection of chemical stimulus involved in sensory perception of pain; detection of mechanical stimulus involved in sensory perception of pain; integral to plasma membrane; ion transport; response to cold; response to drug; response to hydrogen peroxide; response to pain; stereocilium bundle; thermoception IPR002110; IPR020683; IPR005821; Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) TRPA1 ANKTM1 Homo sapiens (Human) TR42190_c1_g8_i1 Q6AZ60 EGFL7_RAT 1.00E-24 GO:0001525; GO:0005509; GO:0005576; GO:0001570 angiogenesis; calcium ion binding; extracellular region; vasculogenesis IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR013111; IPR011489; Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) Egfl7 Cbl20 Megf7 Rattus norvegicus (Rat) TR42190_c1_g8_i2 Q80V70 MEGF6_MOUSE 4.00E-09 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR013111; IPR002049; IPR011489; IPR009030; Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) TR42190_c1_g8_i3 Q9UHF1 EGFL7_HUMAN 3.00E-23 GO:0001525; GO:0005509; GO:0005576; GO:0005615; GO:0045746; GO:0030336; GO:0001938; GO:0001570 angiogenesis; calcium ion binding; extracellular region; extracellular space; negative regulation of Notch signaling pathway; negative regulation of cell migration; positive regulation of endothelial cell proliferation; vasculogenesis IPR000742; IPR001881; IPR013032; IPR018097; IPR013111; IPR011489; IPR009030; Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1) EGFL7 MEGF7 UNQ187/PRO1449 Homo sapiens (Human) TR42190_c1_g8_i4 Q6AZ60 EGFL7_RAT 2.00E-24 GO:0001525; GO:0005509; GO:0005576; GO:0001570 angiogenesis; calcium ion binding; extracellular region; vasculogenesis IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR013111; IPR011489; Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) Egfl7 Cbl20 Megf7 Rattus norvegicus (Rat) TR42191_c0_g1_i3 O60287 NPA1P_HUMAN 2.00E-83 GO:0005730 nucleolus IPR016024; IPR021714; Nucleolar pre-ribosomal-associated protein 1 (Nucleolar protein 254 kDa) (URB1 ribosome biogenesis 1 homolog) URB1 C21orf108 KIAA0539 NOP254 NPA1 Homo sapiens (Human) TR42191_c0_g1_i5 O60287 NPA1P_HUMAN 3.00E-84 GO:0005730 nucleolus IPR016024; IPR021714; Nucleolar pre-ribosomal-associated protein 1 (Nucleolar protein 254 kDa) (URB1 ribosome biogenesis 1 homolog) URB1 C21orf108 KIAA0539 NOP254 NPA1 Homo sapiens (Human) TR42192_c1_g3_i1 Q29467 I5P1_CANFA 6.00E-129 GO:0052659; GO:0052658; GO:0004445; GO:0016020; GO:0046856 "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; inositol-1,4,5-trisphosphate 5-phosphatase activity; inositol-polyphosphate 5-phosphatase activity; membrane; phosphatidylinositol dephosphorylation" IPR005135; IPR000300; "Type I inositol 1,4,5-trisphosphate 5-phosphatase (5PTase) (EC 3.1.3.56)" INPP5A Canis familiaris (Dog) (Canis lupus familiaris) TR42192_c1_g3_i4 Q14642 I5P1_HUMAN 1.00E-135 GO:0007154; GO:0043647; GO:0052659; GO:0052658; GO:0004445; GO:0046856; GO:0005886 P08567 "cell communication; inositol phosphate metabolic process; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; inositol-1,4,5-trisphosphate 5-phosphatase activity; inositol-polyphosphate 5-phosphatase activity; phosphatidylinositol dephosphorylation; plasma membrane" IPR005135; IPR000300; "Type I inositol 1,4,5-trisphosphate 5-phosphatase (5PTase) (EC 3.1.3.56)" INPP5A Homo sapiens (Human) TR42193_c1_g1_i1 Q86XU0 ZN677_HUMAN 5.00E-26 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 677 ZNF677 Homo sapiens (Human) TR42193_c1_g1_i2 A2T736 ZN192_PANTR 4.00E-26 GO:0003677; GO:0005737; GO:0046872; GO:0005730; GO:0003700; GO:0006351 "DNA binding; cytoplasm; metal ion binding; nucleolus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein with KRAB and SCAN domains 8 (Zinc finger protein 192) ZKSCAN8 ZNF192 Pan troglodytes (Chimpanzee) TR42194_c1_g3_i1 Q14995 NR1D2_HUMAN 2.00E-20 GO:0004879; GO:0005654; GO:0043565; GO:0003707; GO:0006367; GO:0008270 O08785; Q96LA8 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleoplasm; sequence-specific DNA binding; steroid hormone receptor activity; transcription initiation from RNA polymerase II promoter; zinc ion binding IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear hormone receptor BD73) (Rev-erb-beta) (V-erbA-related protein 1-related) (EAR-1R) NR1D2 Homo sapiens (Human) TR42194_c1_g3_i2 P55094 NR2C2_RAT 2.00E-97 GO:0030154; GO:0005634; GO:0043565; GO:0003700; GO:0007283; GO:0003707; GO:0006351; GO:0008270 "cell differentiation; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; spermatogenesis; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TR4) (Testicular receptor 4) Nr2c2 Tr4 Rattus norvegicus (Rat) TR42194_c1_g3_i3 Q9N4B8 NHR41_CAEEL 1.00E-37 GO:0005634; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR001628; IPR013088; Nuclear hormone receptor family member nhr-41 nhr-41 Y104H12A.1/Y77E11A.5 Caenorhabditis elegans TR42194_c1_g3_i4 P55094 NR2C2_RAT 9.00E-105 GO:0030154; GO:0005634; GO:0043565; GO:0003700; GO:0007283; GO:0003707; GO:0006351; GO:0008270 "cell differentiation; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; spermatogenesis; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TR4) (Testicular receptor 4) Nr2c2 Tr4 Rattus norvegicus (Rat) TR42195_c0_g1_i1 P21127 CD11B_HUMAN 0 GO:0005524; GO:0006915; GO:0008283; GO:0004693; GO:0005737; GO:0007067; GO:0005634; GO:0004674; GO:0001558; GO:0050684; GO:0006355 O00303; Q13153 "ATP binding; apoptotic process; cell proliferation; cyclin-dependent protein serine/threonine kinase activity; cytoplasm; mitosis; nucleus; protein serine/threonine kinase activity; regulation of cell growth; regulation of mRNA processing; regulation of transcription, DNA-dependent" IPR011009; IPR000719; IPR002290; IPR008271; Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) CDK11B CDC2L1 CDK11 PITSLREA PK58 Homo sapiens (Human) TR42195_c0_g1_i5 P43290 CDC2_PETHY 1.00E-10 GO:0005524; GO:0008353; GO:0051301; GO:0004693; GO:0007067 ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; cell division; cyclin-dependent protein serine/threonine kinase activity; mitosis IPR011009; IPR000719; Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34cdc2) (Fragment) CDC2 Petunia hybrida (Petunia) TR42197_c1_g1_i1 P24733 MYS_AEQIR 0 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR015650; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, striated muscle" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR42197_c1_g1_i3 P24733 MYS_AEQIR 4.00E-160 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR015650; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, striated muscle" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR42198_c2_g1_i1 A2VD00 EIF3A_XENLA 0 GO:0016282; GO:0033290; GO:0005852; GO:0001732; GO:0001731; GO:0006446; GO:0003743 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation initiation complex; formation of translation preinitiation complex; regulation of translational initiation; translation initiation factor activity IPR027512; IPR000717; Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) eif3a eif3s10 Xenopus laevis (African clawed frog) TR42198_c2_g1_i2 A2VD00 EIF3A_XENLA 0 GO:0016282; GO:0033290; GO:0005852; GO:0001732; GO:0001731; GO:0006446; GO:0003743 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation initiation complex; formation of translation preinitiation complex; regulation of translational initiation; translation initiation factor activity IPR027512; IPR000717; Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) eif3a eif3s10 Xenopus laevis (African clawed frog) TR42199_c0_g1_i2 Q60560 SMBP2_MESAU 0 GO:0005524; GO:0043141; GO:0032575; GO:0003677; GO:0030424; GO:0005737; GO:0005634; GO:0043621; GO:0006355; GO:0030529; GO:0043022; GO:0000049; GO:0006351; GO:0008270 "ATP binding; ATP-dependent 5'-3' DNA helicase activity; ATP-dependent 5'-3' RNA helicase activity; DNA binding; axon; cytoplasm; nucleus; protein self-association; regulation of transcription, DNA-dependent; ribonucleoprotein complex; ribosome binding; tRNA binding; transcription, DNA-dependent; zinc ion binding" IPR003593; IPR004483; IPR014001; IPR027417; IPR001374; IPR026853; IPR000058; DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (Insulin II gene enhancer-binding protein) (RIPE3B-binding complex 3B2 p110 subunit) (RIP-1) IGHMBP2 RIP1 SMUBP2 Mesocricetus auratus (Golden hamster) TR42199_c0_g1_i3 P38935 SMBP2_HUMAN 0 GO:0005524; GO:0043141; GO:0032575; GO:0006310; GO:0006281; GO:0006260; GO:0030424; GO:0008219; GO:0005737; GO:0030426; GO:0005634; GO:0051260; GO:0006355; GO:0030529; GO:0043022; GO:0003697; GO:0000049; GO:0006351; GO:0006412; GO:0008270 "ATP binding; ATP-dependent 5'-3' DNA helicase activity; ATP-dependent 5'-3' RNA helicase activity; DNA recombination; DNA repair; DNA replication; axon; cell death; cytoplasm; growth cone; nucleus; protein homooligomerization; regulation of transcription, DNA-dependent; ribonucleoprotein complex; ribosome binding; single-stranded DNA binding; tRNA binding; transcription, DNA-dependent; translation; zinc ion binding" IPR003593; IPR004483; IPR014001; IPR027417; IPR001374; IPR026853; IPR000058; DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2) IGHMBP2 SMBP2 SMUBP2 Homo sapiens (Human) TR42199_c0_g1_i4 Q60560 SMBP2_MESAU 0 GO:0005524; GO:0043141; GO:0032575; GO:0003677; GO:0030424; GO:0005737; GO:0005634; GO:0043621; GO:0006355; GO:0030529; GO:0043022; GO:0000049; GO:0006351; GO:0008270 "ATP binding; ATP-dependent 5'-3' DNA helicase activity; ATP-dependent 5'-3' RNA helicase activity; DNA binding; axon; cytoplasm; nucleus; protein self-association; regulation of transcription, DNA-dependent; ribonucleoprotein complex; ribosome binding; tRNA binding; transcription, DNA-dependent; zinc ion binding" IPR003593; IPR004483; IPR014001; IPR027417; IPR001374; IPR026853; IPR000058; DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (Insulin II gene enhancer-binding protein) (RIPE3B-binding complex 3B2 p110 subunit) (RIP-1) IGHMBP2 RIP1 SMUBP2 Mesocricetus auratus (Golden hamster) TR42200_c4_g2_i1 Q0P5F9 AL8A1_BOVIN 0 GO:0042904; GO:0005737; GO:0005622; GO:0001758; GO:0042574; GO:0042573 9-cis-retinoic acid biosynthetic process; cytoplasm; intracellular; retinal dehydrogenase activity; retinal metabolic process; retinoic acid metabolic process IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Aldehyde dehydrogenase family 8 member A1 (EC 1.2.1.-) ALDH8A1 Bos taurus (Bovine) TR42200_c4_g2_i2 Q07536 MMSA_BOVIN 1.00E-51 GO:0000062; GO:0018478; GO:0004491; GO:0005739; GO:0019859; GO:0006573 fatty-acyl-CoA binding; malonate-semialdehyde dehydrogenase (acetylating) activity; methylmalonate-semialdehyde dehydrogenase (acylating) activity; mitochondrion; thymine metabolic process; valine metabolic process IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR010061; "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (Malonate-semialdehyde dehydrogenase [acylating]) (EC 1.2.1.18) (EC 1.2.1.27) (Aldehyde dehydrogenase family 6 member A1)" ALDH6A1 MMSDH Bos taurus (Bovine) TR42200_c4_g2_i3 Q07XY1 ASTD_SHEFN 2.00E-34 GO:0019544; GO:0019545; GO:0043824 arginine catabolic process to glutamate; arginine catabolic process to succinate; succinylglutamate-semialdehyde dehydrogenase activity IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR017649; Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. N-succinylglutamate 5-semialdehyde dehydrogenase (EC 1.2.1.71) (Succinylglutamic semialdehyde dehydrogenase) (SGSD) astD Sfri_3297 Shewanella frigidimarina (strain NCIMB 400) TR42200_c4_g2_i4 P86808 LMDH_PSEPU 1.00E-19 GO:0016491; GO:0042597 oxidoreductase activity; periplasmic space IPR016161; IPR016162; IPR015590; Limonin dehydrogenase (EC 1.2.1.-) (Fragments) Pseudomonas putida (Arthrobacter siderocapsulatus) TR42201_c1_g1_i3 Q9Y6J0 CABIN_HUMAN 1.00E-50 GO:0016235; GO:0007166; GO:0016568; GO:0005737; GO:0005634; GO:0004864 aggresome; cell surface receptor signaling pathway; chromatin modification; cytoplasm; nucleus; protein phosphatase inhibitor activity IPR015134; IPR013026; IPR011990; IPR019734; Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) CABIN1 KIAA0330 Homo sapiens (Human) TR42202_c0_g1_i3 P81127 SNAG_BOVIN 1.00E-47 GO:0006886; GO:0016020; GO:0005739; GO:0016192 intracellular protein transport; membrane; mitochondrion; vesicle-mediated transport IPR000744; IPR011990; Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein gamma) NAPG SNAPG Bos taurus (Bovine) TR42202_c0_g1_i4 Q5R4C3 TM50B_PONAB 8.00E-58 GO:0016021 integral to membrane IPR007919; Transmembrane protein 50B TMEM50B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42204_c4_g2_i2 Q9JIX8 ACINU_MOUSE 9.00E-41 GO:0061574; GO:0030263; GO:0005737; GO:0030218; GO:0048025; GO:0016607; GO:0003676; GO:0005730; GO:0000166; GO:0043065; GO:0045657 "ASAP complex; apoptotic chromosome condensation; cytoplasm; erythrocyte differentiation; negative regulation of mRNA splicing, via spliceosome; nuclear speck; nucleic acid binding; nucleolus; nucleotide binding; positive regulation of apoptotic process; positive regulation of monocyte differentiation" IPR012677; IPR000504; IPR003034; Apoptotic chromatin condensation inducer in the nucleus (Acinus) Acin1 Acinus Mus musculus (Mouse) TR42204_c4_g2_i7 Q9JIX8 ACINU_MOUSE 2.00E-39 GO:0061574; GO:0030263; GO:0005737; GO:0030218; GO:0048025; GO:0016607; GO:0003676; GO:0005730; GO:0000166; GO:0043065; GO:0045657 "ASAP complex; apoptotic chromosome condensation; cytoplasm; erythrocyte differentiation; negative regulation of mRNA splicing, via spliceosome; nuclear speck; nucleic acid binding; nucleolus; nucleotide binding; positive regulation of apoptotic process; positive regulation of monocyte differentiation" IPR012677; IPR000504; IPR003034; Apoptotic chromatin condensation inducer in the nucleus (Acinus) Acin1 Acinus Mus musculus (Mouse) TR42206_c0_g1_i1 P34400 MIG10_CAEEL 3.00E-69 GO:0031103; GO:0048858; GO:0032584; GO:0008078; GO:0001764; GO:0032809; GO:0018991; GO:0005543; GO:0030334; GO:0007165; GO:0040025 Q10929; O62482 axon regeneration; cell projection morphogenesis; growth cone membrane; mesodermal cell migration; neuron migration; neuronal cell body membrane; oviposition; phospholipid binding; regulation of cell migration; signal transduction; vulval development IPR011993; IPR001849; IPR000159; Abnormal cell migration protein 10 mig-10 F10E9.6/F09G8.1 Caenorhabditis elegans TR42206_c0_g1_i2 Q70E73 RAPH1_HUMAN 1.00E-86 GO:0048675; GO:0007160; GO:0005737; GO:0005856; GO:0030175; GO:0030027; GO:0005543; GO:0005886; GO:0007165 axon extension; cell-matrix adhesion; cytoplasm; cytoskeleton; filopodium; lamellipodium; phospholipid binding; plasma membrane; signal transduction IPR001904; IPR011993; IPR001849; IPR000159; Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) RAPH1 ALS2CR18 ALS2CR9 KIAA1681 LPD PREL2 RMO1 Homo sapiens (Human) TR42206_c0_g1_i6 Q70E73 RAPH1_HUMAN 3.00E-85 GO:0048675; GO:0007160; GO:0005737; GO:0005856; GO:0030175; GO:0030027; GO:0005543; GO:0005886; GO:0007165 axon extension; cell-matrix adhesion; cytoplasm; cytoskeleton; filopodium; lamellipodium; phospholipid binding; plasma membrane; signal transduction IPR001904; IPR011993; IPR001849; IPR000159; Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) RAPH1 ALS2CR18 ALS2CR9 KIAA1681 LPD PREL2 RMO1 Homo sapiens (Human) TR42206_c0_g1_i7 P0CE43 GRB10_RAT 5.00E-38 GO:0005737; GO:0005158; GO:0008286; GO:0030178; GO:0045719; GO:0005543; GO:0042327; GO:0030949 cytoplasm; insulin receptor binding; insulin receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; negative regulation of glycogen biosynthetic process; phospholipid binding; positive regulation of phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway IPR015042; IPR011993; IPR001849; IPR000159; IPR000980; Growth factor receptor-bound protein 10 (GRB10 adapter protein) Grb10 Rattus norvegicus (Rat) TR42206_c0_g1_i8 Q70E73 RAPH1_HUMAN 6.00E-87 GO:0048675; GO:0007160; GO:0005737; GO:0005856; GO:0030175; GO:0030027; GO:0005543; GO:0005886; GO:0007165 axon extension; cell-matrix adhesion; cytoplasm; cytoskeleton; filopodium; lamellipodium; phospholipid binding; plasma membrane; signal transduction IPR001904; IPR011993; IPR001849; IPR000159; Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) RAPH1 ALS2CR18 ALS2CR9 KIAA1681 LPD PREL2 RMO1 Homo sapiens (Human) TR42208_c1_g1_i1 Q9HD20 AT131_HUMAN 0 GO:0005524; GO:0006200; GO:0019829; GO:0016021; GO:0046872 ATP binding; ATP catabolic process; cation-transporting ATPase activity; integral to membrane; metal ion binding IPR006544; IPR023299; IPR018303; IPR008250; IPR001757; IPR023214; Probable cation-transporting ATPase 13A1 (EC 3.6.3.-) ATP13A1 ATP13A KIAA1825 CGI-152 Homo sapiens (Human) TR42208_c1_g1_i2 P38929 ATC2_YEAST 8.00E-09 GO:0005524; GO:0005388; GO:0006874; GO:0000329; GO:0016021; GO:0046872 ATP binding; calcium-transporting ATPase activity; cellular calcium ion homeostasis; fungal-type vacuole membrane; integral to membrane; metal ion binding IPR006408; IPR006068; IPR004014; IPR023299; IPR018303; IPR023298; IPR008250; IPR001757; IPR023214; Calcium-transporting ATPase 2 (EC 3.6.3.8) (Vacuolar Ca(2+)-ATPase) PMC1 YGL006W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42208_c1_g2_i2 P90747 YE56_CAEEL 1.00E-52 GO:0005524; GO:0006200; GO:0019829; GO:0016021; GO:0046872 ATP binding; ATP catabolic process; cation-transporting ATPase activity; integral to membrane; metal ion binding IPR006544; IPR023299; IPR018303; IPR008250; IPR001757; IPR023214; Probable cation-transporting ATPase C10C6.6 (EC 3.6.3.-) C10C6.6 Caenorhabditis elegans TR42209_c0_g3_i2 Q06496 NPT2A_RAT 7.00E-92 GO:0016324; GO:1901684; GO:0031526; GO:0009986; GO:0071248; GO:0071374; GO:0072734; GO:0097187; GO:0005768; GO:1901128; GO:0009100; GO:0042431; GO:0016021; GO:0031226; GO:0001822; GO:0045121; GO:0001503; GO:0048471; GO:0055062; GO:0045838; GO:2000187; GO:2000120; GO:0042803; GO:0051260; GO:0046686; GO:0042493; GO:0032355; GO:0060416; GO:0010288; GO:0032026; GO:0046689; GO:0035864; GO:0097066; GO:0033189; GO:0006814; GO:0015321; GO:0015293; GO:0072350 apical plasma membrane; arsenate ion transmembrane transport; brush border membrane; cell surface; cellular response to metal ion; cellular response to parathyroid hormone stimulus; cellular response to staurosporine; dentinogenesis; endosome; gentamycin metabolic process; glycoprotein metabolic process; indole metabolic process; integral to membrane; intrinsic to plasma membrane; kidney development; membrane raft; ossification; perinuclear region of cytoplasm; phosphate ion homeostasis; positive regulation of membrane potential; positive regulation of phosphate transmembrane transport; positive regulation of sodium-dependent phosphate transport; protein homodimerization activity; protein homooligomerization; response to cadmium ion; response to drug; response to estradiol stimulus; response to growth hormone stimulus; response to lead ion; response to magnesium ion; response to mercury ion; response to potassium ion; response to thyroid hormone stimulus; response to vitamin A; sodium ion transport; sodium-dependent phosphate transmembrane transporter activity; symporter activity; tricarboxylic acid metabolic process IPR003841; Sodium-dependent phosphate transport protein 2A (Sodium-phosphate transport protein 2A) (Na(+)-dependent phosphate cotransporter 2A) (Sodium/phosphate cotransporter 2A) (Na(+)/Pi cotransporter 2A) (NaPi-2a) (Solute carrier family 34 member 1) Slc34a1 Slc17a2 Rattus norvegicus (Rat) TR42211_c2_g2_i2 O43657 TSN6_HUMAN 9.00E-06 GO:0016021; GO:0043123; GO:0004871 integral to membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-6 (Tspan-6) (A15 homolog) (Putative NF-kappa-B-activating protein 321) (T245 protein) (Tetraspanin TM4-D) (Transmembrane 4 superfamily member 6) TSPAN6 TM4SF6 UNQ767/PRO1560 Homo sapiens (Human) TR42212_c0_g2_i1 Q5RBP9 MPEG1_PONAB 1.00E-133 GO:0016021 integral to membrane IPR020864; Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) MPEG1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42212_c0_g2_i5 Q5RBP9 MPEG1_PONAB 1.00E-133 GO:0016021 integral to membrane IPR020864; Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) MPEG1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42212_c0_g3_i2 Q2KJC3 MPEG1_BOVIN 8.00E-14 GO:0016021 integral to membrane IPR020864; Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) MPEG1 Bos taurus (Bovine) TR42213_c2_g1_i2 Q9V3J1 VATH_DROME 0 GO:0015991; GO:0008340; GO:0033227; GO:0033181; GO:0046961; GO:0000221 "ATP hydrolysis coupled proton transport; determination of adult lifespan; dsRNA transport; plasma membrane proton-transporting V-type ATPase complex; proton-transporting ATPase activity, rotational mechanism; vacuolar proton-transporting V-type ATPase, V1 domain" IPR011989; IPR016024; IPR004908; IPR011987; V-type proton ATPase subunit H (V-ATPase subunit H) (Vacuolar proton pump subunit H) (Vacuolar proton pump subunit SFD) VhaSFD CG17332 Drosophila melanogaster (Fruit fly) TR42213_c2_g1_i5 Q9V3J1 VATH_DROME 3.00E-180 GO:0015991; GO:0008340; GO:0033227; GO:0033181; GO:0046961; GO:0000221 "ATP hydrolysis coupled proton transport; determination of adult lifespan; dsRNA transport; plasma membrane proton-transporting V-type ATPase complex; proton-transporting ATPase activity, rotational mechanism; vacuolar proton-transporting V-type ATPase, V1 domain" IPR011989; IPR016024; IPR004908; IPR011987; V-type proton ATPase subunit H (V-ATPase subunit H) (Vacuolar proton pump subunit H) (Vacuolar proton pump subunit SFD) VhaSFD CG17332 Drosophila melanogaster (Fruit fly) TR42214_c0_g1_i1 Q19749 ODP2_CAEEL 2.00E-39 GO:0004742; GO:0006096; GO:0005759; GO:0045254; GO:0006090 dihydrolipoyllysine-residue acetyltransferase activity; glycolysis; mitochondrial matrix; pyruvate dehydrogenase complex; pyruvate metabolic process IPR003016; IPR001078; IPR000089; IPR023213; IPR004167; IPR006257; IPR011053; "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)" F23B12.5 Caenorhabditis elegans TR42214_c0_g2_i1 P86197 ODP2_MESAU 2.00E-27 GO:0004742; GO:0006006; GO:0005759; GO:0006099 dihydrolipoyllysine-residue acetyltransferase activity; glucose metabolic process; mitochondrial matrix; tricarboxylic acid cycle IPR001078; IPR023213; IPR004167; "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2) (Fragments)" DLAT Mesocricetus auratus (Golden hamster) TR42214_c0_g3_i1 P10515 ODP2_HUMAN 8.00E-99 GO:0006085; GO:0004742; GO:0006006; GO:0005967; GO:0006090; GO:0010510; GO:0006099 P11177 acetyl-CoA biosynthetic process; dihydrolipoyllysine-residue acetyltransferase activity; glucose metabolic process; mitochondrial pyruvate dehydrogenase complex; pyruvate metabolic process; regulation of acetyl-CoA biosynthetic process from pyruvate; tricarboxylic acid cycle IPR003016; IPR001078; IPR000089; IPR023213; IPR004167; IPR006257; IPR011053; "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)" DLAT DLTA Homo sapiens (Human) TR42215_c0_g2_i1 P79384 PCCB_PIG 0 GO:0005524; GO:0005759; GO:0004658 ATP binding; mitochondrial matrix; propionyl-CoA carboxylase activity IPR000022; IPR011763; IPR011762; Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3. "Propionyl-CoA carboxylase beta chain, mitochondrial (PCCase subunit beta) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta)" PCCB Sus scrofa (Pig) TR42215_c0_g2_i2 P63407 PCC6_MYCTU 2.00E-97 GO:0005524; GO:0003989; GO:0009317; GO:0005618; GO:0019367; GO:0040007; GO:0004658 "ATP binding; acetyl-CoA carboxylase activity; acetyl-CoA carboxylase complex; cell wall; fatty acid elongation, saturated fatty acid; growth; propionyl-CoA carboxylase activity" IPR000022; IPR011763; IPR011762; Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3. Probable propionyl-CoA carboxylase beta chain 6 (PCCase) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase) accD6 Rv2247 MT2307 MTCY427.28 Mycobacterium tuberculosis TR42216_c0_g1_i1 Q63186 EI2BD_RAT 5.00E-144 GO:0005851; GO:0005085; GO:0042552; GO:0032057; GO:0014003; GO:0001541; GO:0009749; GO:0009408; GO:0043434; GO:0003743; GO:0031369 eukaryotic translation initiation factor 2B complex; guanyl-nucleotide exchange factor activity; myelination; negative regulation of translational initiation in response to stress; oligodendrocyte development; ovarian follicle development; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translation initiation factor activity; translation initiation factor binding IPR000649; Translation initiation factor eIF-2B subunit delta (eIF-2B GDP-GTP exchange factor subunit delta) Eif2b4 Eif2bd Rattus norvegicus (Rat) TR42216_c0_g1_i2 P41111 EI2BD_RABIT 4.00E-139 GO:0051716; GO:0005851; GO:0042552; GO:0014003; GO:0001541; GO:0003743; GO:0006413 cellular response to stimulus; eukaryotic translation initiation factor 2B complex; myelination; oligodendrocyte development; ovarian follicle development; translation initiation factor activity; translational initiation IPR000649; Translation initiation factor eIF-2B subunit delta (eIF-2B GDP-GTP exchange factor subunit delta) EIF2B4 EIF2BD Oryctolagus cuniculus (Rabbit) TR42216_c0_g1_i6 Q63186 EI2BD_RAT 3.00E-144 GO:0005851; GO:0005085; GO:0042552; GO:0032057; GO:0014003; GO:0001541; GO:0009749; GO:0009408; GO:0043434; GO:0003743; GO:0031369 eukaryotic translation initiation factor 2B complex; guanyl-nucleotide exchange factor activity; myelination; negative regulation of translational initiation in response to stress; oligodendrocyte development; ovarian follicle development; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translation initiation factor activity; translation initiation factor binding IPR000649; Translation initiation factor eIF-2B subunit delta (eIF-2B GDP-GTP exchange factor subunit delta) Eif2b4 Eif2bd Rattus norvegicus (Rat) TR42217_c1_g1_i1 Q8BZ39 NMUR2_MOUSE 5.00E-10 GO:0005525; GO:0043006; GO:0050482; GO:0006816; GO:0007417; GO:0007204; GO:0007625; GO:0048016; GO:0016021; GO:0005229; GO:0042924; GO:0001607; GO:0008188; GO:0007200; GO:0005886; GO:0002023; GO:0048265 GTP binding; activation of phospholipase A2 activity by calcium-mediated signaling; arachidonic acid secretion; calcium ion transport; central nervous system development; elevation of cytosolic calcium ion concentration; grooming behavior; inositol phosphate-mediated signaling; integral to membrane; intracellular calcium activated chloride channel activity; neuromedin U binding; neuromedin U receptor activity; neuropeptide receptor activity; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; reduction of food intake in response to dietary excess; response to pain IPR000276; IPR017452; IPR005390; IPR005392; Neuromedin-U receptor 2 (NMU-R2) Nmur2 Mus musculus (Mouse) TR42217_c1_g1_i11 Q8BZ39 NMUR2_MOUSE 2.00E-10 GO:0005525; GO:0043006; GO:0050482; GO:0006816; GO:0007417; GO:0007204; GO:0007625; GO:0048016; GO:0016021; GO:0005229; GO:0042924; GO:0001607; GO:0008188; GO:0007200; GO:0005886; GO:0002023; GO:0048265 GTP binding; activation of phospholipase A2 activity by calcium-mediated signaling; arachidonic acid secretion; calcium ion transport; central nervous system development; elevation of cytosolic calcium ion concentration; grooming behavior; inositol phosphate-mediated signaling; integral to membrane; intracellular calcium activated chloride channel activity; neuromedin U binding; neuromedin U receptor activity; neuropeptide receptor activity; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; reduction of food intake in response to dietary excess; response to pain IPR000276; IPR017452; IPR005390; IPR005392; Neuromedin-U receptor 2 (NMU-R2) Nmur2 Mus musculus (Mouse) TR42217_c1_g1_i2 P06199 ACM2_PIG 2.00E-10 GO:0016907; GO:0007213; GO:0030054; GO:0005887; GO:0045211; GO:0008016 G-protein coupled acetylcholine receptor activity; G-protein coupled acetylcholine receptor signaling pathway; cell junction; integral to plasma membrane; postsynaptic membrane; regulation of heart contraction IPR000276; IPR017452; IPR001065; IPR000995; Muscarinic acetylcholine receptor M2 CHRM2 Sus scrofa (Pig) TR42217_c1_g1_i8 P30372 ACM2_CHICK 5.00E-08 GO:0016907; GO:0030054; GO:0005887; GO:0045211; GO:0008016; GO:0009615 G-protein coupled acetylcholine receptor activity; cell junction; integral to plasma membrane; postsynaptic membrane; regulation of heart contraction; response to virus IPR000276; IPR017452; IPR001065; IPR000995; Muscarinic acetylcholine receptor M2 CHRM2 CM2 Gallus gallus (Chicken) TR42217_c1_g1_i9 P06199 ACM2_PIG 2.00E-10 GO:0016907; GO:0007213; GO:0030054; GO:0005887; GO:0045211; GO:0008016 G-protein coupled acetylcholine receptor activity; G-protein coupled acetylcholine receptor signaling pathway; cell junction; integral to plasma membrane; postsynaptic membrane; regulation of heart contraction IPR000276; IPR017452; IPR001065; IPR000995; Muscarinic acetylcholine receptor M2 CHRM2 Sus scrofa (Pig) TR42218_c1_g1_i4 Q1LWL6 GSE1_DANRE 1.00E-07 IPR022207; Genetic suppressor element 1 gse1 si:dkey-265o13.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR42220_c0_g2_i2 Q9NZ09 UBAP1_HUMAN 1.00E-10 GO:0000813; GO:0005829; GO:0015031; GO:0043130; GO:0043162 ESCRT I complex; cytosol; protein transport; ubiquitin binding; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IPR009060; IPR015940; IPR023340; Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) UBAP1 NAG20 Homo sapiens (Human) TR42221_c0_g1_i1 Q5R874 DHX9_PONAB 0 GO:0005524; GO:0008026; GO:0070937; GO:0070934; GO:0003677; GO:0003723; GO:0005813; GO:0005730; GO:0030529 ATP binding; ATP-dependent helicase activity; CRD-mediated mRNA stability complex; CRD-mediated mRNA stabilization; DNA binding; RNA binding; centrosome; nucleolus; ribonucleoprotein complex IPR011545; IPR002464; IPR014720; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; ATP-dependent RNA helicase A (RHA) (EC 3.6.4.13) (DEAH box protein 9) (Nuclear DNA helicase II) (NDH II) DHX9 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42221_c0_g1_i3 Q08211 DHX9_HUMAN 0 GO:0005524; GO:0004003; GO:0004004; GO:0070937; GO:0070934; GO:0003677; GO:0003723; GO:0034605; GO:0005813; GO:0007623; GO:0005829; GO:0045087; GO:0000398; GO:0005730; GO:0005654; GO:0032481; GO:0030529 P19525; Q9UBU9; Q99873; Q04206; P67809; Q9HA38 "ATP binding; ATP-dependent DNA helicase activity; ATP-dependent RNA helicase activity; CRD-mediated mRNA stability complex; CRD-mediated mRNA stabilization; DNA binding; RNA binding; cellular response to heat; centrosome; circadian rhythm; cytosol; innate immune response; mRNA splicing, via spliceosome; nucleolus; nucleoplasm; positive regulation of type I interferon production; ribonucleoprotein complex" IPR011545; IPR002464; IPR014720; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; ATP-dependent RNA helicase A (RHA) (EC 3.6.4.13) (DEAH box protein 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) DHX9 DDX9 LKP NDH2 Homo sapiens (Human) TR42223_c0_g2_i1 Q8UUZ1 MB212_DANRE 5.00E-09 GO:0048048; GO:0005634 embryonic eye morphogenesis; nucleus IPR024810; IPR024801; IPR000772; Protein mab-21-like 2 mab21l2 Danio rerio (Zebrafish) (Brachydanio rerio) TR42224_c4_g2_i1 Q24323 SEM2A_DROME 1.00E-99 GO:0007411; GO:0070983; GO:0042756; GO:0005576; GO:0007629; GO:0016020; GO:0004872; GO:0016201; GO:0007632 axon guidance; dendrite guidance; drinking behavior; extracellular region; flight behavior; membrane; receptor activity; synaptic target inhibition; visual behavior IPR007110; IPR013783; IPR003599; IPR016201; IPR001627; IPR027231; IPR015943; Semaphorin-2A (Semaphorin-II) (Sema II) Sema-2a dSema-II CG4700 Drosophila melanogaster (Fruit fly) TR42224_c4_g2_i2 Q24323 SEM2A_DROME 1.00E-99 GO:0007411; GO:0070983; GO:0042756; GO:0005576; GO:0007629; GO:0016020; GO:0004872; GO:0016201; GO:0007632 axon guidance; dendrite guidance; drinking behavior; extracellular region; flight behavior; membrane; receptor activity; synaptic target inhibition; visual behavior IPR007110; IPR013783; IPR003599; IPR016201; IPR001627; IPR027231; IPR015943; Semaphorin-2A (Semaphorin-II) (Sema II) Sema-2a dSema-II CG4700 Drosophila melanogaster (Fruit fly) TR42225_c0_g2_i1 O43248 HXC11_HUMAN 2.00E-17 GO:0000978; GO:0001077; GO:0009952; GO:0042733; GO:0060272; GO:0007492; GO:0001656; GO:0005739; GO:0005634; GO:0001759; GO:0009954 RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; anterior/posterior pattern specification; embryonic digit morphogenesis; embryonic skeletal joint morphogenesis; endoderm development; metanephros development; mitochondrion; nucleus; organ induction; proximal/distal pattern formation IPR021918; IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein Hox-C11 (Homeobox protein Hox-3H) HOXC11 HOX3H Homo sapiens (Human) TR42225_c0_g2_i2 P23812 HXD12_MOUSE 4.00E-16 GO:0042733; GO:0005634; GO:0007389; GO:0043565; GO:0003700; GO:0001501; GO:0005667; GO:0006351 "embryonic digit morphogenesis; nucleus; pattern specification process; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; skeletal system development; transcription factor complex; transcription, DNA-dependent" IPR017970; IPR001356; IPR020479; IPR009057; Homeobox protein Hox-D12 (Homeobox protein Hox-4.7) (Homeobox protein Hox-5.6) Hoxd12 Hox-4.7 Hoxd-12 Mus musculus (Mouse) TR42226_c3_g1_i10 P23416 GLRA2_HUMAN 3.00E-87 GO:0030054; GO:0034707; GO:0016934; GO:0016594; GO:0005887; GO:0007218; GO:0045211; GO:0007416; GO:0022824 cell junction; chloride channel complex; extracellular-glycine-gated chloride channel activity; glycine binding; integral to plasma membrane; neuropeptide signaling pathway; postsynaptic membrane; synapse assembly; transmitter-gated ion channel activity IPR006028; IPR008127; IPR008129; IPR006202; IPR006201; IPR006029; IPR018000; Glycine receptor subunit alpha-2 GLRA2 Homo sapiens (Human) TR42226_c3_g1_i2 P23416 GLRA2_HUMAN 9.00E-89 GO:0030054; GO:0034707; GO:0016934; GO:0016594; GO:0005887; GO:0007218; GO:0045211; GO:0007416; GO:0022824 cell junction; chloride channel complex; extracellular-glycine-gated chloride channel activity; glycine binding; integral to plasma membrane; neuropeptide signaling pathway; postsynaptic membrane; synapse assembly; transmitter-gated ion channel activity IPR006028; IPR008127; IPR008129; IPR006202; IPR006201; IPR006029; IPR018000; Glycine receptor subunit alpha-2 GLRA2 Homo sapiens (Human) TR42226_c3_g1_i3 Q08E50 GBRA5_BOVIN 1.00E-45 GO:0004890; GO:0008306; GO:0001662; GO:0044297; GO:0030054; GO:0005254; GO:0034707; GO:0090102; GO:0030425; GO:0005230; GO:0007214; GO:0060119; GO:0060384; GO:0045211; GO:0007605 GABA-A receptor activity; associative learning; behavioral fear response; cell body; cell junction; chloride channel activity; chloride channel complex; cochlea development; dendrite; extracellular ligand-gated ion channel activity; gamma-aminobutyric acid signaling pathway; inner ear receptor cell development; innervation; postsynaptic membrane; sensory perception of sound IPR006028; IPR001390; IPR005435; IPR006202; IPR006201; IPR006029; IPR018000; Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5) GABRA5 Bos taurus (Bovine) TR42226_c3_g1_i4 Q09453 GLRB4_CAEEL 3.00E-59 GO:0030054; GO:0005254; GO:0034707; GO:0005230; GO:0045211 cell junction; chloride channel activity; chloride channel complex; extracellular ligand-gated ion channel activity; postsynaptic membrane IPR006028; IPR006202; IPR006201; IPR006029; IPR018000; Glycine receptor subunit beta-type 4 ggr-1 gbr-4 C09G5.1/C09G5.9 Caenorhabditis elegans TR42226_c3_g1_i5 Q24352 GBRAL_DROME 5.00E-22 GO:0004890; GO:0005261; GO:0030054; GO:0005254; GO:0034707; GO:0016933; GO:0016021; GO:0005886; GO:0045211 GABA-A receptor activity; cation channel activity; cell junction; chloride channel activity; chloride channel complex; extracellular-glycine-gated ion channel activity; integral to membrane; plasma membrane; postsynaptic membrane IPR006028; IPR006202; IPR006201; IPR006029; IPR018000; Gamma-aminobutyric acid receptor alpha-like (GABA(A) receptor alpha-like and glycine receptor-like subunit of Drosophila) (GRD) Grd CG7446 Drosophila melanogaster (Fruit fly) TR42226_c3_g1_i7 Q7TNC8 GLRA2_MOUSE 6.00E-88 GO:0030054; GO:0034707; GO:0016934; GO:0016594; GO:0005887; GO:0007218; GO:0045211; GO:0022824 cell junction; chloride channel complex; extracellular-glycine-gated chloride channel activity; glycine binding; integral to plasma membrane; neuropeptide signaling pathway; postsynaptic membrane; transmitter-gated ion channel activity IPR006028; IPR008127; IPR008129; IPR006202; IPR006201; IPR006029; IPR018000; Glycine receptor subunit alpha-2 Glra2 Mus musculus (Mouse) TR42226_c3_g1_i8 Q61603 GLRA4_MOUSE 8.00E-91 GO:0030054; GO:0005254; GO:0034707; GO:0005230; GO:0016594; GO:0005887; GO:0045211; GO:0022824 cell junction; chloride channel activity; chloride channel complex; extracellular ligand-gated ion channel activity; glycine binding; integral to plasma membrane; postsynaptic membrane; transmitter-gated ion channel activity IPR006028; IPR008127; IPR006202; IPR006201; IPR006029; IPR018000; Glycine receptor subunit alpha-4 Glra4 Mus musculus (Mouse) TR42226_c3_g2_i1 P07510 ACHG_HUMAN 2.00E-06 GO:0015464; GO:0004889; GO:0005892; GO:0030054; GO:0015267; GO:0005887; GO:0006936; GO:0045211; GO:0042391 acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; channel activity; integral to plasma membrane; muscle contraction; postsynaptic membrane; regulation of membrane potential IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit gamma CHRNG ACHRG Homo sapiens (Human) TR42226_c3_g6_i1 P04760 ACHG_MOUSE 1.00E-06 GO:0004889; GO:0005892; GO:0030054; GO:0045211; GO:0042391 acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; postsynaptic membrane; regulation of membrane potential IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit gamma Chrng Acrg Mus musculus (Mouse) TR42227_c0_g1_i3 Q8QZR1 ATTY_MOUSE 1.00E-179 GO:0006103; GO:0006559; GO:0080130; GO:0004838; GO:0016597; GO:0009058; GO:0006536; GO:0005739; GO:0030170; GO:0051384; GO:0046689; GO:0006979; GO:0006572 2-oxoglutarate metabolic process; L-phenylalanine catabolic process; L-phenylalanine:2-oxoglutarate aminotransferase activity; L-tyrosine:2-oxoglutarate aminotransferase activity; amino acid binding; biosynthetic process; glutamate metabolic process; mitochondrion; pyridoxal phosphate binding; response to glucocorticoid stimulus; response to mercury ion; response to oxidative stress; tyrosine catabolic process IPR004839; IPR004838; IPR015424; IPR015421; IPR015422; IPR011715; IPR005958; IPR005957; IPR021178; Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6. Tyrosine aminotransferase (TAT) (EC 2.6.1.5) (L-tyrosine:2-oxoglutarate aminotransferase) Tat Mus musculus (Mouse) TR42231_c0_g2_i1 O95271 TNKS1_HUMAN 0 GO:0005794; GO:0000139; GO:0003950; GO:0016055; GO:0051301; GO:0000775; GO:0051028; GO:0007067; GO:0007052; GO:0043392; GO:0000784; GO:0031965; GO:0005643; GO:0018105; GO:0018107; GO:0000242; GO:0090263; GO:0032212; GO:0045944; GO:0070213; GO:0070198; GO:0070212; GO:0000209; GO:0015031; GO:0051225; GO:0000922; GO:0008270 O35625; Q9HC77; Q96RU3; Q9NWT6 "Golgi apparatus; Golgi membrane; NAD+ ADP-ribosyltransferase activity; Wnt receptor signaling pathway; cell division; chromosome, centromeric region; mRNA transport; mitosis; mitotic spindle organization; negative regulation of DNA binding; nuclear chromosome, telomeric region; nuclear membrane; nuclear pore; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pericentriolar material; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of telomere maintenance via telomerase; positive regulation of transcription from RNA polymerase II promoter; protein auto-ADP-ribosylation; protein localization to chromosome, telomeric region; protein poly-ADP-ribosylation; protein polyubiquitination; protein transport; spindle assembly; spindle pole; zinc ion binding" IPR002110; IPR020683; IPR012317; IPR001660; IPR013761; IPR011510; Tankyrase-1 (TANK1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) TNKS PARP5A PARPL TIN1 TINF1 TNKS1 Homo sapiens (Human) TR42231_c0_g2_i2 O95271 TNKS1_HUMAN 1.00E-139 GO:0005794; GO:0000139; GO:0003950; GO:0016055; GO:0051301; GO:0000775; GO:0051028; GO:0007067; GO:0007052; GO:0043392; GO:0000784; GO:0031965; GO:0005643; GO:0018105; GO:0018107; GO:0000242; GO:0090263; GO:0032212; GO:0045944; GO:0070213; GO:0070198; GO:0070212; GO:0000209; GO:0015031; GO:0051225; GO:0000922; GO:0008270 O35625; Q9HC77; Q96RU3; Q9NWT6 "Golgi apparatus; Golgi membrane; NAD+ ADP-ribosyltransferase activity; Wnt receptor signaling pathway; cell division; chromosome, centromeric region; mRNA transport; mitosis; mitotic spindle organization; negative regulation of DNA binding; nuclear chromosome, telomeric region; nuclear membrane; nuclear pore; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pericentriolar material; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of telomere maintenance via telomerase; positive regulation of transcription from RNA polymerase II promoter; protein auto-ADP-ribosylation; protein localization to chromosome, telomeric region; protein poly-ADP-ribosylation; protein polyubiquitination; protein transport; spindle assembly; spindle pole; zinc ion binding" IPR002110; IPR020683; IPR012317; IPR001660; IPR013761; IPR011510; Tankyrase-1 (TANK1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) TNKS PARP5A PARPL TIN1 TINF1 TNKS1 Homo sapiens (Human) TR42231_c0_g4_i1 Q6UB98 ANR12_HUMAN 7.00E-24 GO:0005737; GO:0005634 cytoplasm; nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) ANKRD12 ANCO2 KIAA0874 Homo sapiens (Human) TR42232_c0_g1_i2 Q9Y345 SC6A5_HUMAN 7.00E-149 GO:0015375; GO:0016021; GO:0005328; GO:0005886; GO:0007268 glycine:sodium symporter activity; integral to membrane; neurotransmitter:sodium symporter activity; plasma membrane; synaptic transmission IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) TR42232_c0_g1_i4 Q58715 Y1319_METJA 3.00E-35 GO:0016021; GO:0005328; GO:0005886 integral to membrane; neurotransmitter:sodium symporter activity; plasma membrane IPR000175; Uncharacterized sodium-dependent transporter MJ1319 MJ1319 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR42232_c0_g1_i6 Q9Y345 SC6A5_HUMAN 9.00E-150 GO:0015375; GO:0016021; GO:0005328; GO:0005886; GO:0007268 glycine:sodium symporter activity; integral to membrane; neurotransmitter:sodium symporter activity; plasma membrane; synaptic transmission IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) TR42232_c0_g1_i9 Q761V0 SC6A5_MOUSE 4.00E-150 GO:0016021; GO:0005328 integral to membrane; neurotransmitter:sodium symporter activity IPR000175; Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) Slc6a5 Glyt2 Mus musculus (Mouse) TR42233_c1_g1_i1 Q9ERI6 RDH14_MOUSE 3.00E-47 GO:0005783; GO:0005739; GO:0016491 endoplasmic reticulum; mitochondrion; oxidoreductase activity IPR002198; IPR002347; IPR016040; Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2) Rdh14 Mus musculus (Mouse) TR42233_c1_g2_i1 Q9QYF1 RDH11_MOUSE 3.00E-50 GO:0052650; GO:0016062; GO:0005789; GO:0016021; GO:0005622; GO:0001917; GO:0042574; GO:0004745 NADP-retinol dehydrogenase activity; adaptation of rhodopsin mediated signaling; endoplasmic reticulum membrane; integral to membrane; intracellular; photoreceptor inner segment; retinal metabolic process; retinol dehydrogenase activity IPR002198; IPR002347; IPR016040; Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (Cell line MC/9.IL4-derived protein 1) (M42C60) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short-chain aldehyde dehydrogenase) (SCALD) Rdh11 Arsdr1 Mdt1 Psdr1 Mus musculus (Mouse) TR42234_c1_g1_i2 Q23356 MIG15_CAEEL 6.00E-171 GO:0005524; GO:0010171; GO:0033563; GO:0002119; GO:0004674; GO:0000003; GO:0004871; GO:0005083 ATP binding; body morphogenesis; dorsal/ventral axon guidance; nematode larval development; protein serine/threonine kinase activity; reproduction; signal transducer activity; small GTPase regulator activity IPR001180; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase mig-15 (EC 2.7.11.1) (Abnormal cell migration protein 15) mig-15 ZC504.4 Caenorhabditis elegans TR42234_c1_g1_i3 Q99JP0 M4K3_MOUSE 8.00E-75 GO:0005524; GO:0007243; GO:0004674; GO:0009411; GO:0005083 Q13094; Q02111 ATP binding; intracellular protein kinase cascade; protein serine/threonine kinase activity; response to UV; small GTPase regulator activity IPR001180; IPR011009; IPR021160; IPR000719; IPR017441; IPR002290; Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) Map4k3 Mus musculus (Mouse) TR42234_c1_g1_i5 Q23356 MIG15_CAEEL 1.00E-170 GO:0005524; GO:0010171; GO:0033563; GO:0002119; GO:0004674; GO:0000003; GO:0004871; GO:0005083 ATP binding; body morphogenesis; dorsal/ventral axon guidance; nematode larval development; protein serine/threonine kinase activity; reproduction; signal transducer activity; small GTPase regulator activity IPR001180; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase mig-15 (EC 2.7.11.1) (Abnormal cell migration protein 15) mig-15 ZC504.4 Caenorhabditis elegans TR42234_c1_g1_i6 P83510 TNIK_MOUSE 9.00E-55 GO:0005524; GO:0016055; GO:0031532; GO:0007256; GO:0005856; GO:0005634; GO:0048471; GO:0046777; GO:0004674; GO:0055037; GO:0048814; GO:0005083 ATP binding; Wnt receptor signaling pathway; actin cytoskeleton reorganization; activation of JNKK activity; cytoskeleton; nucleus; perinuclear region of cytoplasm; protein autophosphorylation; protein serine/threonine kinase activity; recycling endosome; regulation of dendrite morphogenesis; small GTPase regulator activity IPR001180; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Traf2 and NCK-interacting protein kinase (EC 2.7.11.1) Tnik Kiaa0551 Mus musculus (Mouse) TR42235_c1_g1_i2 Q9VXK0 NIPSN_DROME 2.00E-76 IPR011008; IPR012577; Protein NipSnap Nipsnap CG9212 Drosophila melanogaster (Fruit fly) TR42235_c1_g1_i5 Q54I58 NIPSN_DICDI 2.00E-13 IPR011008; IPR012577; Protein NipSnap homolog nipsnap DDB_G0288989 Dictyostelium discoideum (Slime mold) TR42236_c0_g1_i1 Q6NVU2 PPIG_XENTR 0 GO:0051301; GO:0032154; GO:0000777; GO:0005977; GO:0046872; GO:0030496; GO:0005739; GO:0007067; GO:0007084; GO:0016607; GO:0005730; GO:0006470; GO:0004722 cell division; cleavage furrow; condensed chromosome kinetochore; glycogen metabolic process; metal ion binding; midbody; mitochondrion; mitosis; mitotic nuclear envelope reassembly; nuclear speck; nucleolus; protein dephosphorylation; protein serine/threonine phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) ppp1cc TEgg061c20.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42236_c0_g1_i2 P23734 PP12_TRYBB 3.00E-138 GO:0046872; GO:0004721 metal ion binding; phosphoprotein phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1(5.9) (EC 3.1.3.16) Trypanosoma brucei brucei TR42236_c0_g1_i3 P36874 PP1GA_XENLA 0 GO:0051301; GO:0032154; GO:0000777; GO:0005977; GO:0016020; GO:0046872; GO:0030496; GO:0005739; GO:0007067; GO:0007084; GO:0016607; GO:0005730; GO:0006470; GO:0004722 Q9IB67; O42263 cell division; cleavage furrow; condensed chromosome kinetochore; glycogen metabolic process; membrane; metal ion binding; midbody; mitochondrion; mitosis; mitotic nuclear envelope reassembly; nuclear speck; nucleolus; protein dephosphorylation; protein serine/threonine phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1-gamma catalytic subunit A (PP-1G-A) (xPP1-gamma1) (EC 3.1.3.16) ppp1cc-a ppp1cc Xenopus laevis (African clawed frog) TR42236_c0_g1_i5 Q6NVU2 PPIG_XENTR 0 GO:0051301; GO:0032154; GO:0000777; GO:0005977; GO:0046872; GO:0030496; GO:0005739; GO:0007067; GO:0007084; GO:0016607; GO:0005730; GO:0006470; GO:0004722 cell division; cleavage furrow; condensed chromosome kinetochore; glycogen metabolic process; metal ion binding; midbody; mitochondrion; mitosis; mitotic nuclear envelope reassembly; nuclear speck; nucleolus; protein dephosphorylation; protein serine/threonine phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) ppp1cc TEgg061c20.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42236_c0_g1_i7 Q9LR78 BSU1_ARATH 4.00E-67 GO:0009742; GO:0005506; GO:0030145; GO:0005634; GO:0004722; GO:0032880 brassinosteroid mediated signaling pathway; iron ion binding; manganese ion binding; nucleus; protein serine/threonine phosphatase activity; regulation of protein localization IPR015916; IPR015915; IPR004843; IPR006186; IPR012391; Serine/threonine-protein phosphatase BSU1 (EC 3.1.3.16) (Bri1 suppressor protein 1) BSU1 At1g03445 At1g03450 F21B7.7 Arabidopsis thaliana (Mouse-ear cress) TR42236_c0_g1_i8 Q6NVU2 PPIG_XENTR 0 GO:0051301; GO:0032154; GO:0000777; GO:0005977; GO:0046872; GO:0030496; GO:0005739; GO:0007067; GO:0007084; GO:0016607; GO:0005730; GO:0006470; GO:0004722 cell division; cleavage furrow; condensed chromosome kinetochore; glycogen metabolic process; metal ion binding; midbody; mitochondrion; mitosis; mitotic nuclear envelope reassembly; nuclear speck; nucleolus; protein dephosphorylation; protein serine/threonine phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) ppp1cc TEgg061c20.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42238_c1_g1_i3 Q96QK1 VPS35_HUMAN 0 GO:0008219; GO:0005829; GO:0005768; GO:0005765; GO:0015031; GO:0042147 "cell death; cytosol; endosome; lysosomal membrane; protein transport; retrograde transport, endosome to Golgi" IPR016024; IPR005378; Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) VPS35 MEM3 TCCCTA00141 Homo sapiens (Human) TR42240_c1_g2_i1 Q923Z3 MTO1_MOUSE 3.00E-168 GO:0050660; GO:0070899; GO:0005739; GO:0055114 flavin adenine dinucleotide binding; mitochondrial tRNA wobble uridine modification; mitochondrion; oxidation-reduction process IPR013027; IPR004416; IPR026904; IPR002218; IPR020595; "Protein MTO1 homolog, mitochondrial" Mto1 Mus musculus (Mouse) TR42240_c1_g2_i2 Q02YZ3 TRMFO_LACLS 1.00E-13 GO:0030698; GO:0005737; GO:0050660; GO:0047151 "5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity; cytoplasm; flavin adenine dinucleotide binding; methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity" IPR004417; IPR002218; IPR020595; Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO (EC 2.1.1.74) (Folate-dependent tRNA (uracil-5-)-methyltransferase) (Folate-dependent tRNA(M-5-U54)-methyltransferase) trmFO gid LACR_1303 Lactococcus lactis subsp. cremoris (strain SK11) TR42240_c1_g2_i4 Q6MTB4 TMFO2_MYCMS 1.00E-11 GO:0030698; GO:0005737; GO:0050660; GO:0047151 "5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity; cytoplasm; flavin adenine dinucleotide binding; methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity" IPR004417; IPR002218; Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO 2 (EC 2.1.1.74) (Folate-dependent tRNA (uracil-5-)-methyltransferase 2) (Folate-dependent tRNA(M-5-U54)-methyltransferase 2) trmFO2 MSC_0494 Mycoplasma mycoides subsp. mycoides SC (strain PG1) TR42240_c1_g2_i5 Q039E2 TRMFO_LACC3 4.00E-13 GO:0030698; GO:0005737; GO:0050660; GO:0047151 "5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity; cytoplasm; flavin adenine dinucleotide binding; methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity" IPR004417; IPR002218; IPR020595; Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO (EC 2.1.1.74) (Folate-dependent tRNA (uracil-5-)-methyltransferase) (Folate-dependent tRNA(M-5-U54)-methyltransferase) trmFO LSEI_1402 Lactobacillus casei (strain ATCC 334) TR42241_c1_g1_i1 Q8BUR3 FOXJ3_MOUSE 2.00E-21 GO:0008301; GO:0009790; GO:0005634; GO:0007389; GO:0045893; GO:0043565; GO:0003700; GO:0009888; GO:0006351 "DNA binding, bending; embryo development; nucleus; pattern specification process; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; tissue development; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; Forkhead box protein J3 Foxj3 Kiaa1041 Mus musculus (Mouse) TR42241_c1_g1_i10 O00409 FOXN3_HUMAN 2.00E-61 GO:0000077; GO:0000085; GO:0045892; GO:0005634; GO:0043565; GO:0003700; GO:0006351 Q13573 "DNA damage checkpoint; mitotic G2 phase; negative regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; Forkhead box protein N3 (Checkpoint suppressor 1) FOXN3 C14orf116 CHES1 Homo sapiens (Human) TR42241_c1_g1_i2 O00409 FOXN3_HUMAN 2.00E-61 GO:0000077; GO:0000085; GO:0045892; GO:0005634; GO:0043565; GO:0003700; GO:0006351 Q13573 "DNA damage checkpoint; mitotic G2 phase; negative regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; Forkhead box protein N3 (Checkpoint suppressor 1) FOXN3 C14orf116 CHES1 Homo sapiens (Human) TR42241_c1_g1_i4 Q8BUR3 FOXJ3_MOUSE 2.00E-21 GO:0008301; GO:0009790; GO:0005634; GO:0007389; GO:0045893; GO:0043565; GO:0003700; GO:0009888; GO:0006351 "DNA binding, bending; embryo development; nucleus; pattern specification process; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; tissue development; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; Forkhead box protein J3 Foxj3 Kiaa1041 Mus musculus (Mouse) TR42241_c1_g1_i5 O00409 FOXN3_HUMAN 3.00E-62 GO:0000077; GO:0000085; GO:0045892; GO:0005634; GO:0043565; GO:0003700; GO:0006351 Q13573 "DNA damage checkpoint; mitotic G2 phase; negative regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; Forkhead box protein N3 (Checkpoint suppressor 1) FOXN3 C14orf116 CHES1 Homo sapiens (Human) TR42241_c1_g1_i6 Q99958 FOXC2_HUMAN 3.00E-20 GO:0008301; GO:0007219; GO:0001077; GO:0003705; GO:0048844; GO:0001974; GO:0043010; GO:0060038; GO:0031490; GO:0030199; GO:0003690; GO:0035050; GO:0048703; GO:0072011; GO:0072144; GO:0072112; GO:0008286; GO:0001946; GO:0001656; GO:0043066; GO:0000122; GO:0014032; GO:0005634; GO:0001503; GO:0048343; GO:0001569; GO:0033630; GO:0090050; GO:0035470; GO:0050880; GO:0046620; GO:0051090; GO:0043565; GO:0001756; GO:0008134; GO:0005667; GO:0044212; GO:0001657; GO:0048010; GO:0055010 "DNA binding, bending; Notch signaling pathway; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; artery morphogenesis; blood vessel remodeling; camera-type eye development; cardiac muscle cell proliferation; chromatin DNA binding; collagen fibril organization; double-stranded DNA binding; embryonic heart tube development; embryonic viscerocranium morphogenesis; glomerular endothelium development; glomerular mesangial cell development; glomerular visceral epithelial cell differentiation; insulin receptor signaling pathway; lymphangiogenesis; metanephros development; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter; neural crest cell development; nucleus; ossification; paraxial mesodermal cell fate commitment; patterning of blood vessels; positive regulation of cell adhesion mediated by integrin; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of vascular wound healing; regulation of blood vessel size; regulation of organ growth; regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; somitogenesis; transcription factor binding; transcription factor complex; transcription regulatory region DNA binding; ureteric bud development; vascular endothelial growth factor receptor signaling pathway; ventricular cardiac muscle tissue morphogenesis" IPR001766; IPR018122; IPR011991; Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) FOXC2 FKHL14 MFH1 Homo sapiens (Human) TR42241_c1_g1_i7 Q8BUR3 FOXJ3_MOUSE 2.00E-21 GO:0008301; GO:0009790; GO:0005634; GO:0007389; GO:0045893; GO:0043565; GO:0003700; GO:0009888; GO:0006351 "DNA binding, bending; embryo development; nucleus; pattern specification process; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; tissue development; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; Forkhead box protein J3 Foxj3 Kiaa1041 Mus musculus (Mouse) TR42241_c1_g1_i8 O00409 FOXN3_HUMAN 8.00E-63 GO:0000077; GO:0000085; GO:0045892; GO:0005634; GO:0043565; GO:0003700; GO:0006351 Q13573 "DNA damage checkpoint; mitotic G2 phase; negative regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; Forkhead box protein N3 (Checkpoint suppressor 1) FOXN3 C14orf116 CHES1 Homo sapiens (Human) TR42241_c1_g1_i9 Q8BUR3 FOXJ3_MOUSE 1.00E-21 GO:0008301; GO:0009790; GO:0005634; GO:0007389; GO:0045893; GO:0043565; GO:0003700; GO:0009888; GO:0006351 "DNA binding, bending; embryo development; nucleus; pattern specification process; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; tissue development; transcription, DNA-dependent" IPR001766; IPR018122; IPR011991; Forkhead box protein J3 Foxj3 Kiaa1041 Mus musculus (Mouse) TR42242_c0_g1_i1 Q9WVQ1 MAGI2_MOUSE 3.00E-35 GO:0030165; GO:0060395; GO:0031697; GO:0016482; GO:0030425; GO:0072015; GO:0005770; GO:0071850; GO:0032926; GO:0030336; GO:0008285; GO:0051898; GO:0038180; GO:0005634; GO:0048471; GO:0019902; GO:0005886; GO:0010976; GO:0032516; GO:0002092; GO:0014069; GO:0043234; GO:0051291; GO:0043113; GO:0030159; GO:0004871; GO:0036057; GO:0005923 Q61483 PDZ domain binding; SMAD protein signal transduction; beta-1 adrenergic receptor binding; cytoplasmic transport; dendrite; glomerular visceral epithelial cell development; late endosome; mitotic cell cycle arrest; negative regulation of activin receptor signaling pathway; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of protein kinase B signaling cascade; nerve growth factor signaling pathway; nucleus; perinuclear region of cytoplasm; phosphatase binding; plasma membrane; positive regulation of neuron projection development; positive regulation of phosphoprotein phosphatase activity; positive regulation of receptor internalization; postsynaptic density; protein complex; protein heterooligomerization; receptor clustering; receptor signaling complex scaffold activity; signal transducer activity; slit diaphragm; tight junction IPR008145; IPR008144; IPR020590; IPR027417; IPR001478; IPR001202; "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Activin receptor-interacting protein 1) (Acvrip1) (Atrophin-1-interacting protein 1) (AIP-1) (Membrane-associated guanylate kinase inverted 2) (MAGI-2)" Magi2 Acvrinp1 Aip1 Arip1 Mus musculus (Mouse) TR42242_c1_g1_i2 Q9D6K5 SYJ2B_MOUSE 3.00E-09 GO:0009986; GO:0006897; GO:0031307; GO:0048312; GO:0032926; GO:0048471; GO:0032927; GO:2000010; GO:0002092 A2ARV4 cell surface; endocytosis; integral to mitochondrial outer membrane; intracellular distribution of mitochondria; negative regulation of activin receptor signaling pathway; perinuclear region of cytoplasm; positive regulation of activin receptor signaling pathway; positive regulation of protein localization to cell surface; positive regulation of receptor internalization IPR001478; Synaptojanin-2-binding protein (Activin receptor-interacting protein 2) (Activin receptor-interacting protein 4) (Mitochondrial outer membrane protein 25) Synj2bp Arip2 Omp25 Mus musculus (Mouse) TR42242_c1_g2_i1 Q4L1J4 MAGI1_RAT 2.00E-80 GO:0005524; GO:0005737; GO:0016020; GO:0005923 ATP binding; cytoplasm; membrane; tight junction IPR008145; IPR008144; IPR020590; IPR027417; IPR001478; IPR001202; "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1)" Magi1 Baiap1 Bap1 Rattus norvegicus (Rat) TR42242_c1_g2_i2 Q96QZ7 MAGI1_HUMAN 1.00E-79 GO:0005524; GO:0007155; GO:0042995; GO:0007166; GO:0005911; GO:0005737; GO:0005886; GO:0008022; GO:0006461; GO:0005923 P06463; O94868; P46940; O60333-3 ATP binding; cell adhesion; cell projection; cell surface receptor signaling pathway; cell-cell junction; cytoplasm; plasma membrane; protein C-terminus binding; protein complex assembly; tight junction IPR008145; IPR008144; IPR020590; IPR027417; IPR001478; IPR001202; "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Atrophin-1-interacting protein 3) (AIP-3) (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Trinucleotide repeat-containing gene 19 protein) (WW domain-containing protein 3) (WWP3)" MAGI1 AIP3 BAIAP1 BAP1 TNRC19 Homo sapiens (Human) TR42242_c1_g2_i3 Q6RHR9 MAGI1_MOUSE 1.00E-80 GO:0005524; GO:0005737; GO:0005634; GO:0005886; GO:0005923 Q9Z206 ATP binding; cytoplasm; nucleus; plasma membrane; tight junction IPR008145; IPR008144; IPR020590; IPR027417; IPR001478; IPR001202; "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1)" Magi1 Baiap1 Bap1 Mus musculus (Mouse) TR42242_c1_g2_i4 Q6RHR9 MAGI1_MOUSE 1.00E-15 GO:0005524; GO:0005737; GO:0005634; GO:0005886; GO:0005923 Q9Z206 ATP binding; cytoplasm; nucleus; plasma membrane; tight junction IPR008145; IPR008144; IPR020590; IPR027417; IPR001478; IPR001202; "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1)" Magi1 Baiap1 Bap1 Mus musculus (Mouse) TR42242_c2_g1_i1 Q9EQJ9 MAGI3_MOUSE 3.00E-17 GO:0005524; GO:0005911; GO:0005634; GO:0005886; GO:0043507; GO:0005923 P01135 ATP binding; cell-cell junction; nucleus; plasma membrane; positive regulation of JUN kinase activity; tight junction IPR008145; IPR008144; IPR020590; IPR027417; IPR001478; IPR001202; "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (Membrane-associated guanylate kinase inverted 3) (MAGI-3)" Magi3 Kiaa1634 Mus musculus (Mouse) TR42242_c3_g1_i1 Q8DMQ7 KGUA_THEEB 5.00E-09 GO:0005524; GO:0005737; GO:0004385; GO:0006163 ATP binding; cytoplasm; guanylate kinase activity; purine nucleotide metabolic process IPR008145; IPR008144; IPR017665; IPR020590; IPR027417; Guanylate kinase (EC 2.7.4.8) (GMP kinase) gmk tll0054 Thermosynechococcus elongatus (strain BP-1) TR42243_c2_g2_i1 Q3ULD5 MCCB_MOUSE 0 GO:0005524; GO:0015936; GO:0006552; GO:0004485; GO:0005759; GO:0005739 ATP binding; coenzyme A metabolic process; leucine catabolic process; methylcrotonoyl-CoA carboxylase activity; mitochondrial matrix; mitochondrion IPR000022; IPR011763; IPR011762; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3. "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta)" Mccc2 Mus musculus (Mouse) TR42243_c2_g2_i3 Q3ULD5 MCCB_MOUSE 2.00E-64 GO:0005524; GO:0015936; GO:0006552; GO:0004485; GO:0005759; GO:0005739 ATP binding; coenzyme A metabolic process; leucine catabolic process; methylcrotonoyl-CoA carboxylase activity; mitochondrial matrix; mitochondrion IPR000022; IPR011763; IPR011762; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3. "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta)" Mccc2 Mus musculus (Mouse) TR42244_c3_g1_i1 Q55470 Y514_SYNY3 3.00E-16 GO:0016787 hydrolase activity IPR001279; Uncharacterized protein sll0514 sll0514 Synechocystis sp. (strain PCC 6803 / Kazusa) TR42244_c3_g1_i2 Q503E1 INT11_DANRE 0 GO:0016787; GO:0005634 hydrolase activity; nucleus IPR001279; IPR022712; IPR011108; Integrator complex subunit 11 (Int11) (EC 3.1.27.-) (Cleavage and polyadenylation-specific factor 3-like protein) (CPSF3-like protein) cpsf3l ints11 zgc:110671 Danio rerio (Zebrafish) (Brachydanio rerio) TR42244_c3_g1_i6 Q503E1 INT11_DANRE 0 GO:0016787; GO:0005634 hydrolase activity; nucleus IPR001279; IPR022712; IPR011108; Integrator complex subunit 11 (Int11) (EC 3.1.27.-) (Cleavage and polyadenylation-specific factor 3-like protein) (CPSF3-like protein) cpsf3l ints11 zgc:110671 Danio rerio (Zebrafish) (Brachydanio rerio) TR42248_c1_g3_i2 P32674 PFLD_ECOLI 5.00E-20 GO:0005737; GO:0008861 cytoplasm; formate C-acetyltransferase activity IPR019777; IPR001150; IPR010098; IPR004184; Fermentation; pyruvate fermentation; formate from pyruvate: step 1/1. Formate acetyltransferase 2 (EC 2.3.1.54) (Pyruvate formate-lyase 2) pflD yijL b3951 JW3923 Escherichia coli (strain K12) TR42248_c1_g3_i3 P32674 PFLD_ECOLI 5.00E-20 GO:0005737; GO:0008861 cytoplasm; formate C-acetyltransferase activity IPR019777; IPR001150; IPR010098; IPR004184; Fermentation; pyruvate fermentation; formate from pyruvate: step 1/1. Formate acetyltransferase 2 (EC 2.3.1.54) (Pyruvate formate-lyase 2) pflD yijL b3951 JW3923 Escherichia coli (strain K12) TR42249_c1_g2_i1 Q03049 YD541_YEAST 5.00E-39 GO:0004090; GO:0044237; GO:0050662 carbonyl reductase (NADPH) activity; cellular metabolic process; coenzyme binding IPR001509; IPR016040; Putative uncharacterized oxidoreductase YDR541C (EC 1.1.1.-) YDR541C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42249_c1_g2_i2 Q9UT59 YKJ7_SCHPO 3.00E-38 GO:0044237; GO:0050662; GO:0005829; GO:0005634; GO:0016491 cellular metabolic process; coenzyme binding; cytosol; nucleus; oxidoreductase activity IPR001509; IPR016040; Putative uncharacterized oxidoreductase C513.07 (EC 1.1.1.-) SPAC513.07 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42249_c1_g2_i4 Q9UT59 YKJ7_SCHPO 3.00E-38 GO:0044237; GO:0050662; GO:0005829; GO:0005634; GO:0016491 cellular metabolic process; coenzyme binding; cytosol; nucleus; oxidoreductase activity IPR001509; IPR016040; Putative uncharacterized oxidoreductase C513.07 (EC 1.1.1.-) SPAC513.07 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR4225_c0_g2_i1 Q96MM6 HS12B_HUMAN 7.00E-09 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR42251_c2_g1_i11 O42574 ADRB1_XENLA 6.00E-06 GO:0005088; GO:0071880; GO:0004940; GO:0005769; GO:0016021; GO:0005886; GO:0032320; GO:0030819; GO:0043950; GO:0045823; GO:0005057 Ras guanyl-nucleotide exchange factor activity; adenylate cyclase-activating adrenergic receptor signaling pathway; beta1-adrenergic receptor activity; early endosome; integral to membrane; plasma membrane; positive regulation of Ras GTPase activity; positive regulation of cAMP biosynthetic process; positive regulation of cAMP-mediated signaling; positive regulation of heart contraction; receptor signaling protein activity IPR002233; IPR000507; IPR000276; IPR017452; Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) (x-BETA1AR) adrb1 Xenopus laevis (African clawed frog) TR42251_c2_g1_i5 Q923Y7 TAAR4_RAT 2.00E-06 GO:0007610; GO:0016021; GO:0005886; GO:0001594 behavior; integral to membrane; plasma membrane; trace-amine receptor activity IPR000276; IPR017452; IPR009132; Trace amine-associated receptor 4 (TaR-4) (Trace amine receptor 4) (2-phenylethylamine receptor) (Trace amine receptor 2) (TaR-2) Taar4 Ta2 Tar2 Trar2 Rattus norvegicus (Rat) TR42251_c2_g1_i6 Q8BZ39 NMUR2_MOUSE 2.00E-07 GO:0005525; GO:0043006; GO:0050482; GO:0006816; GO:0007417; GO:0007204; GO:0007625; GO:0048016; GO:0016021; GO:0005229; GO:0042924; GO:0001607; GO:0008188; GO:0007200; GO:0005886; GO:0002023; GO:0048265 GTP binding; activation of phospholipase A2 activity by calcium-mediated signaling; arachidonic acid secretion; calcium ion transport; central nervous system development; elevation of cytosolic calcium ion concentration; grooming behavior; inositol phosphate-mediated signaling; integral to membrane; intracellular calcium activated chloride channel activity; neuromedin U binding; neuromedin U receptor activity; neuropeptide receptor activity; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; reduction of food intake in response to dietary excess; response to pain IPR000276; IPR017452; IPR005390; IPR005392; Neuromedin-U receptor 2 (NMU-R2) Nmur2 Mus musculus (Mouse) TR42253_c0_g2_i2 Q8VI36 PAXI_MOUSE 8.00E-64 GO:0000187; GO:0048754; GO:0005938; GO:0006928; GO:0005856; GO:0007010; GO:0005925; GO:0048041; GO:0007229; GO:0030027; GO:0030032; GO:0018108; GO:0030159; GO:0008270 P11627; P34152; P18031; Q64727 activation of MAPK activity; branching morphogenesis of an epithelial tube; cell cortex; cellular component movement; cytoskeleton; cytoskeleton organization; focal adhesion; focal adhesion assembly; integrin-mediated signaling pathway; lamellipodium; lamellipodium assembly; peptidyl-tyrosine phosphorylation; receptor signaling complex scaffold activity; zinc ion binding IPR001904; IPR001781; Paxillin Pxn Mus musculus (Mouse) TR42253_c0_g3_i1 Q8VI36 PAXI_MOUSE 2.00E-81 GO:0000187; GO:0048754; GO:0005938; GO:0006928; GO:0005856; GO:0007010; GO:0005925; GO:0048041; GO:0007229; GO:0030027; GO:0030032; GO:0018108; GO:0030159; GO:0008270 P11627; P34152; P18031; Q64727 activation of MAPK activity; branching morphogenesis of an epithelial tube; cell cortex; cellular component movement; cytoskeleton; cytoskeleton organization; focal adhesion; focal adhesion assembly; integrin-mediated signaling pathway; lamellipodium; lamellipodium assembly; peptidyl-tyrosine phosphorylation; receptor signaling complex scaffold activity; zinc ion binding IPR001904; IPR001781; Paxillin Pxn Mus musculus (Mouse) TR42254_c0_g1_i1 Q4WY82 PPOC_ASPFU 2.00E-10 GO:0051213; GO:0020037; GO:0042744; GO:0005506; GO:0016705; GO:0004601; GO:0001516 "dioxygenase activity; heme binding; hydrogen peroxide catabolic process; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; peroxidase activity; prostaglandin biosynthetic process" IPR001128; IPR010255; IPR002007; IPR019791; Linoleate 10R-lipoxygenase (EC 1.13.11.62) (Cyclooxygenase-like fatty acid oxygenase) (Fatty acid oxygenase ppoC) (Linoleate 10R-dioxygenase) (10R-DOX) (Psi-producing oxygenase C) (AfPpoC) ppoC AFUA_3G12120 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) TR42254_c0_g2_i1 Q23490 MLT7_CAEEL 1.00E-15 GO:0042338; GO:0020037; GO:0046872; GO:0002119; GO:0018149; GO:0004601; GO:0040032; GO:0006979 cuticle development involved in collagen and cuticulin-based cuticle molting cycle; heme binding; metal ion binding; nematode larval development; peptide cross-linking; peroxidase activity; post-embryonic body morphogenesis; response to oxidative stress IPR010255; IPR002007; IPR019791; IPR003582; Peroxidase mlt-7 (EC 1.11.1.7) (Molting defective protein 7) (MoLT-7) [Cleaved into: Peroxidase mlt-7 light chain; Peroxidase mlt-7 heavy chain] mlt-7 ZK430.8 Caenorhabditis elegans TR42256_c3_g1_i1 A8IW99 PLD6_CHLRE 6.00E-49 GO:0004519; GO:0016021; GO:0016042; GO:0007126; GO:0046872; GO:0005741; GO:0090305 endonuclease activity; integral to membrane; lipid catabolic process; meiosis; metal ion binding; mitochondrial outer membrane; nucleic acid phosphodiester bond hydrolysis IPR025202; IPR001736; IPR000571; Mitochondrial cardiolipin hydrolase (EC 3.1.-.-) (Phospholipase D6 homolog) (PLD 6) CHLREDRAFT_190403 Chlamydomonas reinhardtii (Chlamydomonas smithii) TR42257_c2_g1_i1 P08548 LIN1_NYCCO 2.00E-23 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR42257_c2_g1_i2 P16425 Y2R2_DROME 2.00E-13 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Putative 115 kDa protein in type-1 retrotransposable element R1DM (ORF 2) (Putative 115 kDa protein in type I retrotransposable element R1DM) Drosophila melanogaster (Fruit fly) TR42257_c2_g1_i3 P08548 LIN1_NYCCO 3.00E-23 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR42258_c0_g1_i10 O46504 PDPR_BOVIN 0 GO:0004047; GO:0006546; GO:0005759; GO:0016491 aminomethyltransferase activity; glycine catabolic process; mitochondrial matrix; oxidoreductase activity IPR006076; IPR013977; IPR006222; IPR027266; "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPr)" PDPR Bos taurus (Bovine) TR42258_c0_g1_i2 O46504 PDPR_BOVIN 0 GO:0004047; GO:0006546; GO:0005759; GO:0016491 aminomethyltransferase activity; glycine catabolic process; mitochondrial matrix; oxidoreductase activity IPR006076; IPR013977; IPR006222; IPR027266; "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPr)" PDPR Bos taurus (Bovine) TR42258_c0_g1_i3 B0K242 GCST_THEPX 1.00E-43 GO:0004047; GO:0005737; GO:0006546; GO:0008483 aminomethyltransferase activity; cytoplasm; glycine catabolic process; transaminase activity IPR013977; IPR006222; IPR006223; IPR022903; IPR027266; Aminomethyltransferase (EC 2.1.2.10) (Glycine cleavage system T protein) gcvT Teth514_0232 Thermoanaerobacter sp. (strain X514) TR42258_c0_g1_i5 O46504 PDPR_BOVIN 0 GO:0004047; GO:0006546; GO:0005759; GO:0016491 aminomethyltransferase activity; glycine catabolic process; mitochondrial matrix; oxidoreductase activity IPR006076; IPR013977; IPR006222; IPR027266; "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPr)" PDPR Bos taurus (Bovine) TR42258_c0_g1_i6 B0K242 GCST_THEPX 8.00E-44 GO:0004047; GO:0005737; GO:0006546; GO:0008483 aminomethyltransferase activity; cytoplasm; glycine catabolic process; transaminase activity IPR013977; IPR006222; IPR006223; IPR022903; IPR027266; Aminomethyltransferase (EC 2.1.2.10) (Glycine cleavage system T protein) gcvT Teth514_0232 Thermoanaerobacter sp. (strain X514) TR42258_c0_g1_i8 B0K242 GCST_THEPX 1.00E-43 GO:0004047; GO:0005737; GO:0006546; GO:0008483 aminomethyltransferase activity; cytoplasm; glycine catabolic process; transaminase activity IPR013977; IPR006222; IPR006223; IPR022903; IPR027266; Aminomethyltransferase (EC 2.1.2.10) (Glycine cleavage system T protein) gcvT Teth514_0232 Thermoanaerobacter sp. (strain X514) TR42259_c0_g1_i2 Q9STN3 SPT51_ARATH 1.00E-84 GO:0005634; GO:0032784; GO:0006357; GO:0005840; GO:0003735; GO:0006351; GO:0006412 "nucleus; regulation of DNA-dependent transcription, elongation; regulation of transcription from RNA polymerase II promoter; ribosome; structural constituent of ribosome; transcription, DNA-dependent; translation" IPR005824; IPR005825; IPR017071; IPR005100; IPR006645; IPR008991; Putative transcription elongation factor SPT5 homolog 1 At4g08350 T28D5.40 Arabidopsis thaliana (Mouse-ear cress) TR42259_c0_g1_i3 O00267 SPT5H_HUMAN 0 GO:0006370; GO:0032044; GO:0007049; GO:0003682; GO:0006338; GO:0032785; GO:0000122; GO:0032786; GO:0016239; GO:0045944; GO:0050434; GO:0010033; GO:0045090; GO:0006368 P24928; P62937; P63272 "7-methylguanosine mRNA capping; DSIF complex; cell cycle; chromatin binding; chromatin remodeling; negative regulation of DNA-dependent transcription, elongation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of DNA-dependent transcription, elongation; positive regulation of macroautophagy; positive regulation of transcription from RNA polymerase II promoter; positive regulation of viral transcription; response to organic substance; retroviral genome replication; transcription elongation from RNA polymerase II promoter" IPR005824; IPR024945; IPR022581; IPR017071; IPR005100; IPR006645; IPR008991; Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) SUPT5H SPT5 SPT5H Homo sapiens (Human) TR42259_c0_g2_i3 P0CR72 SPT6_CRYNJ 3.00E-06 GO:0003677; GO:0003723; GO:0016788; GO:0005634; GO:0032784; GO:0006357; GO:0006351 "DNA binding; RNA binding; hydrolase activity, acting on ester bonds; nucleus; regulation of DNA-dependent transcription, elongation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent" IPR003029; IPR022967; IPR012337; IPR010994; IPR000980; IPR028083; IPR027999; IPR028088; IPR028231; IPR023323; IPR023097; IPR017072; IPR006641; Transcription elongation factor SPT6 (Chromatin elongation factor SPT6) SPT6 CNB04370 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) TR42260_c0_g1_i1 A8WGA3 LFN1L_DANRE 5.00E-33 GO:0030054; GO:0016021; GO:0045202 cell junction; integral to membrane; synapse IPR000483; IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeat and fibronectin type III domain-containing protein 1-like protein lrfn1l zgc:172282 Danio rerio (Zebrafish) (Brachydanio rerio) TR42260_c0_g1_i2 Q99PH1 LRRC4_MOUSE 2.00E-18 GO:0030054; GO:0016021; GO:0045211 cell junction; integral to membrane; postsynaptic membrane IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; IPR026906; IPR026882; Leucine-rich repeat-containing protein 4 (Brain tumor-associated protein MBAG1) (Netrin-G2 ligand) (NGL-2) Lrrc4 Mus musculus (Mouse) TR42260_c0_g1_i3 Q80XU8 LRFN4_MOUSE 6.00E-28 GO:0016021 integral to membrane IPR000483; IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeat and fibronectin type-III domain-containing protein 4 Lrfn4 Salm3 Mus musculus (Mouse) TR42260_c0_g1_i4 A8WGA3 LFN1L_DANRE 4.00E-33 GO:0030054; GO:0016021; GO:0045202 cell junction; integral to membrane; synapse IPR000483; IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeat and fibronectin type III domain-containing protein 1-like protein lrfn1l zgc:172282 Danio rerio (Zebrafish) (Brachydanio rerio) TR42260_c0_g1_i5 Q80XU8 LRFN4_MOUSE 5.00E-28 GO:0016021 integral to membrane IPR000483; IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeat and fibronectin type-III domain-containing protein 4 Lrfn4 Salm3 Mus musculus (Mouse) TR42260_c0_g1_i6 A8WGA3 LFN1L_DANRE 5.00E-33 GO:0030054; GO:0016021; GO:0045202 cell junction; integral to membrane; synapse IPR000483; IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeat and fibronectin type III domain-containing protein 1-like protein lrfn1l zgc:172282 Danio rerio (Zebrafish) (Brachydanio rerio) TR42261_c3_g2_i11 Q18673 NEPL1_CAEEL 5.00E-114 GO:0016021; GO:0046872; GO:0004222; GO:0006508 integral to membrane; metal ion binding; metalloendopeptidase activity; proteolysis IPR024079; IPR000718; IPR018497; IPR008753; Neprilysin-1 (EC 3.4.24.-) nep-1 ZK20.6 Caenorhabditis elegans TR42261_c3_g2_i13 Q9JLI3 MMEL1_MOUSE 5.00E-100 GO:0005794; GO:0005783; GO:0005615; GO:0016021; GO:0004222; GO:0006508; GO:0008270 Golgi apparatus; endoplasmic reticulum; extracellular space; integral to membrane; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR000718; IPR018497; IPR008753; "Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) (Neprilysin-like 1) (NL-1) (Neprilysin-like peptidase) (NEPLP) (Soluble secreted endopeptidase) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]" Mmel1 Nep2 Nl1 Sep Mus musculus (Mouse) TR42261_c3_g2_i15 P08049 NEP_RABIT 3.00E-103 GO:0030424; GO:0050435; GO:0005903; GO:0071492; GO:0071493; GO:0071345; GO:0046449; GO:0030425; GO:0016021; GO:0001822; GO:0004222; GO:0044306; GO:0042277; GO:0005886; GO:0006508; GO:0090399; GO:0019233; GO:0008021; GO:0008270 axon; beta-amyloid metabolic process; brush border; cellular response to UV-A; cellular response to UV-B; cellular response to cytokine stimulus; creatinine metabolic process; dendrite; integral to membrane; kidney development; metalloendopeptidase activity; neuron projection terminus; peptide binding; plasma membrane; proteolysis; replicative senescence; sensory perception of pain; synaptic vesicle; zinc ion binding IPR024079; IPR000718; IPR018497; IPR008753; Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) MME Oryctolagus cuniculus (Rabbit) TR42261_c3_g2_i5 P08049 NEP_RABIT 2.00E-80 GO:0030424; GO:0050435; GO:0005903; GO:0071492; GO:0071493; GO:0071345; GO:0046449; GO:0030425; GO:0016021; GO:0001822; GO:0004222; GO:0044306; GO:0042277; GO:0005886; GO:0006508; GO:0090399; GO:0019233; GO:0008021; GO:0008270 axon; beta-amyloid metabolic process; brush border; cellular response to UV-A; cellular response to UV-B; cellular response to cytokine stimulus; creatinine metabolic process; dendrite; integral to membrane; kidney development; metalloendopeptidase activity; neuron projection terminus; peptide binding; plasma membrane; proteolysis; replicative senescence; sensory perception of pain; synaptic vesicle; zinc ion binding IPR024079; IPR000718; IPR018497; IPR008753; Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) MME Oryctolagus cuniculus (Rabbit) TR42261_c3_g2_i8 Q9JLI3 MMEL1_MOUSE 8.00E-168 GO:0005794; GO:0005783; GO:0005615; GO:0016021; GO:0004222; GO:0006508; GO:0008270 Golgi apparatus; endoplasmic reticulum; extracellular space; integral to membrane; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR000718; IPR018497; IPR008753; "Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) (Neprilysin-like 1) (NL-1) (Neprilysin-like peptidase) (NEPLP) (Soluble secreted endopeptidase) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]" Mmel1 Nep2 Nl1 Sep Mus musculus (Mouse) TR42263_c1_g1_i2 Q921M3 SF3B3_MOUSE 0 GO:0008380; GO:0005689; GO:0071013; GO:0006397; GO:0003676 RNA splicing; U12-type spliceosomal complex; catalytic step 2 spliceosome; mRNA processing; nucleic acid binding IPR004871; IPR017986; Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (Spliceosome-associated protein 130) (SAP 130) Sf3b3 Kiaa0017 Mus musculus (Mouse) TR42263_c1_g1_i3 Q921M3 SF3B3_MOUSE 0 GO:0008380; GO:0005689; GO:0071013; GO:0006397; GO:0003676 RNA splicing; U12-type spliceosomal complex; catalytic step 2 spliceosome; mRNA processing; nucleic acid binding IPR004871; IPR017986; Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (Spliceosome-associated protein 130) (SAP 130) Sf3b3 Kiaa0017 Mus musculus (Mouse) TR42264_c0_g2_i1 O14617 AP3D1_HUMAN 0 GO:0005794; GO:0000139; GO:0008089; GO:0048490; GO:0048007; GO:0010008; GO:0006726; GO:0006886; GO:0005765; GO:0030117; GO:0051138; GO:0033365; GO:0008565; GO:0061088; GO:0048499; GO:0043195; GO:0005215 "Golgi apparatus; Golgi membrane; anterograde axon cargo transport; anterograde synaptic vesicle transport; antigen processing and presentation, exogenous lipid antigen via MHC class Ib; endosome membrane; eye pigment biosynthetic process; intracellular protein transport; lysosomal membrane; membrane coat; positive regulation of NK T cell differentiation; protein localization to organelle; protein transporter activity; regulation of sequestering of zinc ion; synaptic vesicle membrane organization; terminal bouton; transporter activity" IPR017105; IPR011989; IPR016024; IPR010474; IPR002553; AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin) AP3D1 PRO0039 Homo sapiens (Human) TR42264_c0_g3_i4 O14617 AP3D1_HUMAN 1.00E-66 GO:0005794; GO:0000139; GO:0008089; GO:0048490; GO:0048007; GO:0010008; GO:0006726; GO:0006886; GO:0005765; GO:0030117; GO:0051138; GO:0033365; GO:0008565; GO:0061088; GO:0048499; GO:0043195; GO:0005215 "Golgi apparatus; Golgi membrane; anterograde axon cargo transport; anterograde synaptic vesicle transport; antigen processing and presentation, exogenous lipid antigen via MHC class Ib; endosome membrane; eye pigment biosynthetic process; intracellular protein transport; lysosomal membrane; membrane coat; positive regulation of NK T cell differentiation; protein localization to organelle; protein transporter activity; regulation of sequestering of zinc ion; synaptic vesicle membrane organization; terminal bouton; transporter activity" IPR017105; IPR011989; IPR016024; IPR010474; IPR002553; AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin) AP3D1 PRO0039 Homo sapiens (Human) TR42264_c0_g3_i5 P54362 AP3D_DROME 2.00E-26 GO:0030123; GO:0005795; GO:0006895; GO:0005798; GO:0007220; GO:0030665; GO:0048072; GO:0008340; GO:0006897; GO:0005783; GO:0006887; GO:0008057; GO:0006886; GO:0005770; GO:0007041; GO:0007040; GO:0060967; GO:0006727; GO:0008565 AP-3 adaptor complex; Golgi stack; Golgi to endosome transport; Golgi-associated vesicle; Notch receptor processing; clathrin-coated vesicle membrane; compound eye pigmentation; determination of adult lifespan; endocytosis; endoplasmic reticulum; exocytosis; eye pigment granule organization; intracellular protein transport; late endosome; lysosomal transport; lysosome organization; negative regulation of gene silencing by RNA; ommochrome biosynthetic process; protein transporter activity IPR017105; IPR011989; IPR016024; IPR010474; IPR002553; AP-3 complex subunit delta (Delta adaptin subunit of AP-3) (Delta-adaptin) (Garnet protein) g CG10986 Drosophila melanogaster (Fruit fly) TR42264_c0_g3_i8 Q865S1 AP3D1_BOVIN 4.00E-25 GO:0000139; GO:0008089; GO:0048490; GO:0048007; GO:0010008; GO:0006886; GO:0030117; GO:0051138; GO:0033365; GO:0008565; GO:0048499; GO:0043195 "Golgi membrane; anterograde axon cargo transport; anterograde synaptic vesicle transport; antigen processing and presentation, exogenous lipid antigen via MHC class Ib; endosome membrane; intracellular protein transport; membrane coat; positive regulation of NK T cell differentiation; protein localization to organelle; protein transporter activity; synaptic vesicle membrane organization; terminal bouton" IPR017105; IPR011989; IPR016024; IPR010474; IPR002553; AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adapter-related protein complex 3 subunit delta-1) (BLVPCP1) (Bovine leukemia virus cell receptor) (BLV-R) (Delta-adaptin) AP3D1 BLVR Bos taurus (Bovine) TR42266_c0_g1_i1 Q07869 PPARA_HUMAN 2.00E-33 GO:0035095; GO:0008144; GO:0070166; GO:0008544; GO:0006631; GO:0015908; GO:0007507; GO:0004879; GO:0008289; GO:0042157; GO:0032099; GO:0045776; GO:0010887; GO:0045820; GO:0010745; GO:1901215; GO:0032091; GO:0010871; GO:0010891; GO:0000122; GO:2000678; GO:0005654; GO:0032000; GO:0072366; GO:0072363; GO:0072369; GO:0001666; GO:0032868; GO:0043565; GO:0003707; GO:0006367; GO:0042060; GO:0008270 Q3L8U1-3 behavioral response to nicotine; drug binding; enamel mineralization; epidermis development; fatty acid metabolic process; fatty acid transport; heart development; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; lipid binding; lipoprotein metabolic process; negative regulation of appetite; negative regulation of blood pressure; negative regulation of cholesterol storage; negative regulation of glycolysis; negative regulation of macrophage derived foam cell differentiation; negative regulation of neuron death; negative regulation of protein binding; negative regulation of receptor biosynthetic process; negative regulation of sequestering of triglyceride; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription regulatory region DNA binding; nucleoplasm; positive regulation of fatty acid beta-oxidation; regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter; regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter; regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter; response to hypoxia; response to insulin stimulus; sequence-specific DNA binding; steroid hormone receptor activity; transcription initiation from RNA polymerase II promoter; wound healing; zinc ion binding IPR003074; IPR003076; IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) PPARA NR1C1 PPAR Homo sapiens (Human) TR42266_c0_g1_i3 Q5I7G2 RXR_LYMST 0 GO:0030424; GO:0005737; GO:0030426; GO:0016020; GO:0007275; GO:0005634; GO:0016918; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "axon; cytoplasm; growth cone; membrane; multicellular organismal development; nucleus; retinal binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR000003; IPR001723; IPR001628; IPR013088; Retinoic acid receptor RXR (Retinoid X receptor) (LymRXR) RXR Lymnaea stagnalis (Great pond snail) TR42266_c0_g1_i4 P49116 NR2C2_HUMAN 3.00E-33 GO:0030154; GO:0021549; GO:0051321; GO:0007399; GO:0005654; GO:0048520; GO:0040019; GO:0045944; GO:0046982; GO:0004872; GO:0043565; GO:0003700; GO:0007283; GO:0003707; GO:0003713; GO:0006367; GO:0008270 cell differentiation; cerebellum development; meiotic cell cycle; nervous system development; nucleoplasm; positive regulation of behavior; positive regulation of embryonic development; positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; spermatogenesis; steroid hormone receptor activity; transcription coactivator activity; transcription initiation from RNA polymerase II promoter; zinc ion binding IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4) NR2C2 TAK1 TR4 Homo sapiens (Human) TR42266_c0_g1_i5 Q8T5C6 RXR_BIOGL 0 GO:0005634; GO:0016918; GO:0043565; GO:0003700; GO:0003707; GO:0006351; GO:0008270 "nucleus; retinal binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR000003; IPR001723; IPR001628; IPR013088; Retinoic acid receptor RXR (RXR-like protein) (Retinoid X receptor) (BgRXR) RXR Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail) TR42267_c0_g1_i3 Q6P791 LTOR1_RAT 3.00E-20 GO:0005794; GO:0071986; GO:0016049; GO:0034613; GO:0071230; GO:0042632; GO:0032439; GO:0007032; GO:0005085; GO:0005765; GO:0005764; GO:0032418; GO:0007040; GO:0005886; GO:0043410; GO:0032008; GO:0010874; GO:0010872; GO:0060620; GO:0001919 Q9JHS3; O88653 Golgi apparatus; Ragulator complex; cell growth; cellular protein localization; cellular response to amino acid stimulus; cholesterol homeostasis; endosome localization; endosome organization; guanyl-nucleotide exchange factor activity; lysosomal membrane; lysosome; lysosome localization; lysosome organization; plasma membrane; positive regulation of MAPK cascade; positive regulation of TOR signaling cascade; regulation of cholesterol efflux; regulation of cholesterol esterification; regulation of cholesterol import; regulation of receptor recycling IPR028209; IPR026310; Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) Lamtor1 Rattus norvegicus (Rat) TR42267_c0_g1_i6 Q6P791 LTOR1_RAT 3.00E-20 GO:0005794; GO:0071986; GO:0016049; GO:0034613; GO:0071230; GO:0042632; GO:0032439; GO:0007032; GO:0005085; GO:0005765; GO:0005764; GO:0032418; GO:0007040; GO:0005886; GO:0043410; GO:0032008; GO:0010874; GO:0010872; GO:0060620; GO:0001919 Q9JHS3; O88653 Golgi apparatus; Ragulator complex; cell growth; cellular protein localization; cellular response to amino acid stimulus; cholesterol homeostasis; endosome localization; endosome organization; guanyl-nucleotide exchange factor activity; lysosomal membrane; lysosome; lysosome localization; lysosome organization; plasma membrane; positive regulation of MAPK cascade; positive regulation of TOR signaling cascade; regulation of cholesterol efflux; regulation of cholesterol esterification; regulation of cholesterol import; regulation of receptor recycling IPR028209; IPR026310; Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) Lamtor1 Rattus norvegicus (Rat) TR42268_c0_g2_i2 Q9U1M2 TM120_DROME 2.00E-90 GO:0050829; GO:0016021; GO:0045089 Q9W1C9 defense response to Gram-negative bacterium; integral to membrane; positive regulation of innate immune response IPR012926; Transmembrane protein 120 homolog CG32795 Drosophila melanogaster (Fruit fly) TR42269_c0_g1_i1 Q9QZS7 NPHN_MOUSE 4.00E-06 GO:0007254; GO:0007155; GO:0042995; GO:0032836; GO:0072015; GO:0005887; GO:0007520; GO:0030838; GO:0044062; GO:0007519; GO:0036057 JNK cascade; cell adhesion; cell projection; glomerular basement membrane development; glomerular visceral epithelial cell development; integral to plasma membrane; myoblast fusion; positive regulation of actin filament polymerization; regulation of excretion; skeletal muscle tissue development; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Mus musculus (Mouse) TR42269_c4_g1_i1 Q9VS29 DSCL_DROME 9.00E-58 GO:0007156; GO:0005887; GO:0048812 homophilic cell adhesion; integral to plasma membrane; neuron projection morphogenesis IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Down syndrome cell adhesion molecule-like protein Dscam2 Dscam2 CG42256 Drosophila melanogaster (Fruit fly) TR42269_c4_g3_i1 Q9VS29 DSCL_DROME 6.00E-15 GO:0007156; GO:0005887; GO:0048812 homophilic cell adhesion; integral to plasma membrane; neuron projection morphogenesis IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Down syndrome cell adhesion molecule-like protein Dscam2 Dscam2 CG42256 Drosophila melanogaster (Fruit fly) TR42270_c1_g1_i1 P16622 HEMH_YEAST 4.00E-96 GO:0004325; GO:0006783; GO:0005743 P38800 ferrochelatase activity; heme biosynthetic process; mitochondrial inner membrane IPR001015; IPR019772; Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. "Ferrochelatase, mitochondrial (EC 4.99.1.1) (Heme synthase) (Protoheme ferro-lyase)" HEM15 YOR176W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42270_c1_g1_i2 O57478 HEMH_XENLA 4.00E-144 GO:0051537; GO:0004325; GO:0006783; GO:0046872; GO:0005743 "2 iron, 2 sulfur cluster binding; ferrochelatase activity; heme biosynthetic process; metal ion binding; mitochondrial inner membrane" IPR001015; IPR019772; Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. "Ferrochelatase, mitochondrial (EC 4.99.1.1) (Heme synthase) (Protoheme ferro-lyase)" fech Xenopus laevis (African clawed frog) TR42272_c0_g1_i5 Q9H8V3 ECT2_HUMAN 1.00E-07 GO:0005096; GO:0005089; GO:0032863; GO:0032147; GO:0097190; GO:0000902; GO:0071277; GO:0070301; GO:0071479; GO:0097149; GO:0032154; GO:0000910; GO:0005829; GO:0030496; GO:0048011; GO:0005634; GO:0005543; GO:0043089; GO:0043123; GO:0043065; GO:0032467; GO:0045666; GO:0042307; GO:0042803; GO:0051260; GO:0015031; GO:0051988; GO:0004871; GO:0007264; GO:0005923; GO:0070830 P16333 GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; activation of Rac GTPase activity; activation of protein kinase activity; apoptotic signaling pathway; cell morphogenesis; cellular response to calcium ion; cellular response to hydrogen peroxide; cellular response to ionizing radiation; centralspindlin complex; cleavage furrow; cytokinesis; cytosol; midbody; neurotrophin TRK receptor signaling pathway; nucleus; phospholipid binding; positive regulation of Cdc42 GTPase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptotic process; positive regulation of cytokinesis; positive regulation of neuron differentiation; positive regulation of protein import into nucleus; protein homodimerization activity; protein homooligomerization; protein transport; regulation of attachment of spindle microtubules to kinetochore; signal transducer activity; small GTPase mediated signal transduction; tight junction; tight junction assembly IPR001357; IPR000219; IPR026817; IPR001331; IPR011993; IPR001849; Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) ECT2 Homo sapiens (Human) TR42272_c0_g1_i6 A8MVX0 ARG33_HUMAN 7.00E-16 GO:0005089; GO:0035023 Rho guanyl-nucleotide exchange factor activity; regulation of Rho protein signal transduction IPR000219; Rho guanine nucleotide exchange factor 33 ARHGEF33 Homo sapiens (Human) TR42273_c0_g2_i1 Q6BU94 PRP46_DEBHA 4.00E-08 GO:0008380; GO:0007049; GO:0005737; GO:0006397; GO:0005681 RNA splicing; cell cycle; cytoplasm; mRNA processing; spliceosomal complex IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Pre-mRNA-splicing factor PRP46 (Pre-mRNA-processing protein 46) PRP46 DEHA2C12650g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR42273_c0_g2_i10 Q6BU94 PRP46_DEBHA 4.00E-08 GO:0008380; GO:0007049; GO:0005737; GO:0006397; GO:0005681 RNA splicing; cell cycle; cytoplasm; mRNA processing; spliceosomal complex IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Pre-mRNA-splicing factor PRP46 (Pre-mRNA-processing protein 46) PRP46 DEHA2C12650g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR42273_c0_g2_i11 Q09715 TUP11_SCHPO 1.00E-11 GO:0006342; GO:0005829; GO:0042393; GO:0045014; GO:0000122; GO:0000790; GO:0043234; GO:0003714; GO:0006351 "chromatin silencing; cytosol; histone binding; negative regulation of transcription by glucose; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; protein complex; transcription corepressor activity; transcription, DNA-dependent" IPR020472; IPR013890; IPR015943; IPR001680; IPR019775; IPR017986; Transcriptional repressor tup11 tup11 SPAC18B11.10 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42273_c0_g2_i13 Q5E9I8 DCA11_BOVIN 6.00E-173 GO:0016567 protein ubiquitination IPR020472; IPR015943; IPR001680; IPR017986; IPR017399; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 11 (WD repeat-containing protein 23) DCAF11 WDR23 Bos taurus (Bovine) TR42273_c0_g2_i3 Q5E9I8 DCA11_BOVIN 1.00E-172 GO:0016567 protein ubiquitination IPR020472; IPR015943; IPR001680; IPR017986; IPR017399; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 11 (WD repeat-containing protein 23) DCAF11 WDR23 Bos taurus (Bovine) TR42273_c0_g2_i6 Q6BU94 PRP46_DEBHA 4.00E-08 GO:0008380; GO:0007049; GO:0005737; GO:0006397; GO:0005681 RNA splicing; cell cycle; cytoplasm; mRNA processing; spliceosomal complex IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Pre-mRNA-splicing factor PRP46 (Pre-mRNA-processing protein 46) PRP46 DEHA2C12650g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR42273_c0_g2_i7 Q5E9I8 DCA11_BOVIN 6.00E-173 GO:0016567 protein ubiquitination IPR020472; IPR015943; IPR001680; IPR017986; IPR017399; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 11 (WD repeat-containing protein 23) DCAF11 WDR23 Bos taurus (Bovine) TR42273_c0_g2_i9 Q5E9I8 DCA11_BOVIN 8.00E-173 GO:0016567 protein ubiquitination IPR020472; IPR015943; IPR001680; IPR017986; IPR017399; Protein modification; protein ubiquitination. DDB1- and CUL4-associated factor 11 (WD repeat-containing protein 23) DCAF11 WDR23 Bos taurus (Bovine) TR42274_c0_g2_i1 Q9P2S6 ANKY1_HUMAN 2.00E-12 GO:0046872 metal ion binding IPR002110; IPR020683; IPR003409; IPR002893; Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc finger MYND domain-containing protein 13) ANKMY1 TSAL1 ZMYND13 Homo sapiens (Human) TR42274_c2_g1_i1 Q05974 RAB1A_LYMST 3.00E-96 GO:0005525; GO:0005794; GO:0005783; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; endoplasmic reticulum; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-1A RAB1A Lymnaea stagnalis (Great pond snail) TR42274_c2_g3_i1 Q05974 RAB1A_LYMST 9.00E-96 GO:0005525; GO:0005794; GO:0005783; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; endoplasmic reticulum; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-1A RAB1A Lymnaea stagnalis (Great pond snail) TR42275_c1_g1_i1 P11536 E74EB_DROME 1.00E-50 GO:0001077; GO:0006914; GO:0005634; GO:0048477; GO:0040034; GO:0035071; GO:0043565 "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; autophagy; nucleus; oogenesis; regulation of development, heterochronic; salivary gland cell autophagic cell death; sequence-specific DNA binding" IPR000418; IPR011991; Ecdysone-induced protein 74EF isoform B (ETS-related protein E74B) Eip74EF E74 CG32180 Drosophila melanogaster (Fruit fly) TR42275_c1_g1_i12 Q91712 ETS2B_XENLA 5.00E-15 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR016311; IPR027276; IPR011991; Protein c-ets-2-B (C-ets-2B) ets2-b Xenopus laevis (African clawed frog) TR42275_c1_g1_i13 P11536 E74EB_DROME 7.00E-51 GO:0001077; GO:0006914; GO:0005634; GO:0048477; GO:0040034; GO:0035071; GO:0043565 "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; autophagy; nucleus; oogenesis; regulation of development, heterochronic; salivary gland cell autophagic cell death; sequence-specific DNA binding" IPR000418; IPR011991; Ecdysone-induced protein 74EF isoform B (ETS-related protein E74B) Eip74EF E74 CG32180 Drosophila melanogaster (Fruit fly) TR42275_c1_g1_i15 P11536 E74EB_DROME 7.00E-55 GO:0001077; GO:0006914; GO:0005634; GO:0048477; GO:0040034; GO:0035071; GO:0043565 "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; autophagy; nucleus; oogenesis; regulation of development, heterochronic; salivary gland cell autophagic cell death; sequence-specific DNA binding" IPR000418; IPR011991; Ecdysone-induced protein 74EF isoform B (ETS-related protein E74B) Eip74EF E74 CG32180 Drosophila melanogaster (Fruit fly) TR42275_c1_g1_i2 P41158 ELK4_MOUSE 3.00E-16 GO:0003682; GO:0005737; GO:0070932; GO:0000122; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "chromatin binding; cytoplasm; histone H3 deacetylation; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR011991; ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1) Elk4 Sap1 Mus musculus (Mouse) TR42275_c1_g1_i3 Q04688 ELG_DROME 4.00E-15 GO:0005634; GO:0045451; GO:0010821; GO:0006355; GO:0043565; GO:0003700 "nucleus; pole plasm oskar mRNA localization; regulation of mitochondrion organization; regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity" IPR000418; IPR024668; IPR003118; IPR013761; IPR016312; IPR011991; DNA-binding protein Ets97D (D-elg) Ets97D elg CG6338 Drosophila melanogaster (Fruit fly) TR42275_c1_g1_i5 P11536 E74EB_DROME 1.00E-50 GO:0001077; GO:0006914; GO:0005634; GO:0048477; GO:0040034; GO:0035071; GO:0043565 "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; autophagy; nucleus; oogenesis; regulation of development, heterochronic; salivary gland cell autophagic cell death; sequence-specific DNA binding" IPR000418; IPR011991; Ecdysone-induced protein 74EF isoform B (ETS-related protein E74B) Eip74EF E74 CG32180 Drosophila melanogaster (Fruit fly) TR42275_c1_g1_i7 P11536 E74EB_DROME 8.00E-55 GO:0001077; GO:0006914; GO:0005634; GO:0048477; GO:0040034; GO:0035071; GO:0043565 "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; autophagy; nucleus; oogenesis; regulation of development, heterochronic; salivary gland cell autophagic cell death; sequence-specific DNA binding" IPR000418; IPR011991; Ecdysone-induced protein 74EF isoform B (ETS-related protein E74B) Eip74EF E74 CG32180 Drosophila melanogaster (Fruit fly) TR42276_c0_g1_i1 P98168 ZXDA_HUMAN 4.00E-88 GO:0046872; GO:0003676; GO:0005634; GO:0045893; GO:0003700; GO:0006351 P33076; Q2QGD7 "metal ion binding; nucleic acid binding; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger X-linked protein ZXDA ZXDA Homo sapiens (Human) TR42276_c0_g1_i4 P98168 ZXDA_HUMAN 8.00E-88 GO:0046872; GO:0003676; GO:0005634; GO:0045893; GO:0003700; GO:0006351 P33076; Q2QGD7 "metal ion binding; nucleic acid binding; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger X-linked protein ZXDA ZXDA Homo sapiens (Human) TR42277_c0_g1_i1 Q9CQZ6 NDUB3_MOUSE 7.00E-15 GO:0022900; GO:0016021; GO:0005743; GO:0005747 electron transport chain; integral to membrane; mitochondrial inner membrane; mitochondrial respiratory chain complex I IPR012576; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (Complex I-B12) (CI-B12) (NADH-ubiquinone oxidoreductase B12 subunit) Ndufb3 Mus musculus (Mouse) TR42277_c1_g1_i2 P49746 TSP3_HUMAN 0 GO:0060346; GO:0005509; GO:0007160; GO:0005576; GO:0003417; GO:0008201; GO:0043931; GO:0048471 bone trabecula formation; calcium ion binding; cell-matrix adhesion; extracellular region; growth plate cartilage development; heparin binding; ossification involved in bone maturation; perinuclear region of cytoplasm IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR018097; IPR001791; IPR024665; IPR003367; IPR017897; IPR008859; Thrombospondin-3 THBS3 TSP3 Homo sapiens (Human) TR42277_c1_g1_i5 P49746 TSP3_HUMAN 2.00E-139 GO:0060346; GO:0005509; GO:0007160; GO:0005576; GO:0003417; GO:0008201; GO:0043931; GO:0048471 bone trabecula formation; calcium ion binding; cell-matrix adhesion; extracellular region; growth plate cartilage development; heparin binding; ossification involved in bone maturation; perinuclear region of cytoplasm IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR018097; IPR001791; IPR024665; IPR003367; IPR017897; IPR008859; Thrombospondin-3 THBS3 TSP3 Homo sapiens (Human) TR42278_c4_g1_i3 Q53G44 IF44L_HUMAN 3.00E-27 GO:0005737; GO:0051607; GO:0006955 cytoplasm; defense response to virus; immune response IPR024644; IPR027417; Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) TR42278_c4_g1_i4 Q8BV66 IFI44_MOUSE 8.00E-25 GO:0005737 cytoplasm IPR024644; IPR027417; IPR006571; Interferon-induced protein 44 (Microtubule-associated protein 44) Ifi44 Mtap44 Mus musculus (Mouse) TR42278_c4_g3_i5 Q5ZJX5 K1609_CHICK 1.00E-06 IPR006571; TLD domain-containing protein 1 (TBC/LysM-associated domain-containing protein 1) TLDC1 RCJMB04_14k7 Gallus gallus (Chicken) TR42278_c4_g3_i6 Q9BDB7 IF44L_MOUSE 7.00E-21 GO:0005737; GO:0006955 cytoplasm; immune response IPR024644; IPR027417; Interferon-induced protein 44-like [Cleaved into: Minor histocompatibility antigen HA-28 (HLA-HA28) (IFL8)] Ifi44l H28 Mus musculus (Mouse) TR42279_c1_g1_i2 Q5T3F8 TM63B_HUMAN 3.00E-94 GO:0016021; GO:0000166 Q3TWI9 integral to membrane; nucleotide binding IPR003864; IPR027815; IPR012677; IPR026957; Transmembrane protein 63B TMEM63B C6orf110 Homo sapiens (Human) TR42279_c1_g1_i3 Q9P1W3 TM63C_HUMAN 1.00E-81 GO:0016021 integral to membrane IPR003864; IPR027815; IPR026957; Transmembrane protein 63C TMEM63C C14orf171 Homo sapiens (Human) TR42279_c1_g1_i5 Q5T3F8 TM63B_HUMAN 4.00E-92 GO:0016021; GO:0000166 Q3TWI9 integral to membrane; nucleotide binding IPR003864; IPR027815; IPR012677; IPR026957; Transmembrane protein 63B TMEM63B C6orf110 Homo sapiens (Human) TR42281_c2_g3_i1 B4KS18 AKTP2_DROMO 1.00E-25 GO:0016881 acid-amino acid ligase activity IPR000608; IPR016135; Protein crossbronx-like GI18531 Drosophila mojavensis (Fruit fly) TR42281_c2_g3_i3 Q498F8 AKTPA_XENLA 2.00E-87 GO:0070695; GO:0016881; GO:0006915; GO:0045022; GO:0007032; GO:0008333; GO:0007040; GO:0005886; GO:0015031 FHF complex; acid-amino acid ligase activity; apoptotic process; early endosome to late endosome transport; endosome organization; endosome to lysosome transport; lysosome organization; plasma membrane; protein transport IPR000608; IPR016135; AKT-interacting protein homolog A aktip-a fts-a Xenopus laevis (African clawed frog) TR42282_c1_g3_i1 Q8C206 GP157_MOUSE 1.00E-15 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR022343; IPR017981; IPR000832; IPR017452; Probable G-protein coupled receptor 157 Gpr157 Mus musculus (Mouse) TR42283_c2_g2_i1 A1L1W9 MOT10_DANRE 2.00E-114 GO:0016021; GO:0005886; GO:0055085 integral to membrane; plasma membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 10 (MCT 10) (Solute carrier family 16 member 10) slc16a10 si:ch211-241j12.1 zgc:158478 Danio rerio (Zebrafish) (Brachydanio rerio) TR42283_c2_g2_i2 A1L1W9 MOT10_DANRE 4.00E-114 GO:0016021; GO:0005886; GO:0055085 integral to membrane; plasma membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 10 (MCT 10) (Solute carrier family 16 member 10) slc16a10 si:ch211-241j12.1 zgc:158478 Danio rerio (Zebrafish) (Brachydanio rerio) TR42284_c2_g1_i1 Q93073 SBP2L_HUMAN 2.00E-91 IPR004038; Selenocysteine insertion sequence-binding protein 2-like (SECIS-binding protein 2-like) SECISBP2L KIAA0256 Homo sapiens (Human) TR42286_c3_g2_i2 Q5R5I4 UB2L3_PONAB 7.00E-66 GO:0005524; GO:0008283; GO:0071385; GO:0005737; GO:0005634; GO:0070979; GO:0006355; GO:0003713; GO:0006351; GO:0004842 "ATP binding; cell proliferation; cellular response to glucocorticoid stimulus; cytoplasm; nucleus; protein K11-linked ubiquitination; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity" IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 L3 (EC 6.3.2.19) (Ubiquitin carrier protein L3) (Ubiquitin-protein ligase L3) UBE2L3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42286_c3_g2_i4 Q5R5I4 UB2L3_PONAB 3.00E-67 GO:0005524; GO:0008283; GO:0071385; GO:0005737; GO:0005634; GO:0070979; GO:0006355; GO:0003713; GO:0006351; GO:0004842 "ATP binding; cell proliferation; cellular response to glucocorticoid stimulus; cytoplasm; nucleus; protein K11-linked ubiquitination; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity" IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 L3 (EC 6.3.2.19) (Ubiquitin carrier protein L3) (Ubiquitin-protein ligase L3) UBE2L3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42286_c3_g2_i5 Q32LD2 UBE2T_BOVIN 6.00E-17 GO:0005524; GO:0006281; GO:0003682; GO:0005634; GO:0070979; GO:0044314; GO:0035519; GO:0070936; GO:0085020; GO:0070534; GO:0051865; GO:0006513; GO:0004842 ATP binding; DNA repair; chromatin binding; nucleus; protein K11-linked ubiquitination; protein K27-linked ubiquitination; protein K29-linked ubiquitination; protein K48-linked ubiquitination; protein K6-linked ubiquitination; protein K63-linked ubiquitination; protein autoubiquitination; protein monoubiquitination; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 T (EC 6.3.2.19) (Ubiquitin carrier protein T) (Ubiquitin-protein ligase T) UBE2T Bos taurus (Bovine) TR42287_c0_g2_i2 Q502K9 SELT2_DANRE 3.00E-56 GO:0045454; GO:0008430 cell redox homeostasis; selenium binding IPR011893; IPR019389; IPR012336; Selenoprotein T2 selt2 sept2 zgc:112046 Danio rerio (Zebrafish) (Brachydanio rerio) TR42287_c0_g2_i4 Q502K9 SELT2_DANRE 3.00E-56 GO:0045454; GO:0008430 cell redox homeostasis; selenium binding IPR011893; IPR019389; IPR012336; Selenoprotein T2 selt2 sept2 zgc:112046 Danio rerio (Zebrafish) (Brachydanio rerio) TR42289_c0_g2_i1 Q03720 SLO_DROME 0 GO:0048512; GO:0060072; GO:0045433; GO:0043005; GO:0043025; GO:0042493; GO:0005249; GO:0008076 P12370; Q8MR31; Q8IPH9-1; P00528 "circadian behavior; large conductance calcium-activated potassium channel activity; male courtship behavior, veined wing generated song production; neuron projection; neuronal cell body; response to drug; voltage-gated potassium channel activity; voltage-gated potassium channel complex" IPR024939; IPR005821; IPR003091; IPR003929; IPR016040; Calcium-activated potassium channel slowpoke (dSlo) (BK channel) (Maxi K channel) (MaxiK) slo CG10693 Drosophila melanogaster (Fruit fly) TR42289_c0_g2_i4 Q12791 KCMA1_HUMAN 0 GO:0003779; GO:0007628; GO:0016324; GO:0042491; GO:0007596; GO:0015269; GO:0005901; GO:0048469; GO:0030007; GO:0005783; GO:0009897; GO:0060082; GO:0016021; GO:0060072; GO:0045475; GO:0046872; GO:0045794; GO:0050885; GO:0043065; GO:0045211; GO:0051260; GO:0019228; GO:0032344; GO:0042391; GO:0060087; GO:0051592; GO:0034465; GO:0001666; GO:0006970; GO:0046541; GO:0007605; GO:0060083; GO:0007268; GO:0043195; GO:0005249; GO:0008076 actin binding; adult walking behavior; apical plasma membrane; auditory receptor cell differentiation; blood coagulation; calcium-activated potassium channel activity; caveola; cell maturation; cellular potassium ion homeostasis; endoplasmic reticulum; external side of plasma membrane; eye blink reflex; integral to membrane; large conductance calcium-activated potassium channel activity; locomotor rhythm; metal ion binding; negative regulation of cell volume; neuromuscular process controlling balance; positive regulation of apoptotic process; postsynaptic membrane; protein homooligomerization; regulation of action potential in neuron; regulation of aldosterone metabolic process; regulation of membrane potential; relaxation of vascular smooth muscle; response to calcium ion; response to carbon monoxide; response to hypoxia; response to osmotic stress; saliva secretion; sensory perception of sound; smooth muscle contraction involved in micturition; synaptic transmission; terminal bouton; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR024939; IPR005821; IPR003091; IPR003929; IPR016040; IPR003148; "Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo)" KCNMA1 KCNMA SLO Homo sapiens (Human) TR42289_c0_g2_i5 Q8QFV0 KCNT1_CHICK 2.00E-31 GO:0015269; GO:0005249; GO:0008076 calcium-activated potassium channel activity; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR013099; IPR003929; IPR016040; Potassium channel subfamily T member 1 (Sequence like a calcium-activated potassium channel subunit) KCNT1 SLACK Gallus gallus (Chicken) TR42289_c0_g2_i7 Q95V25 SLO1_CAEEL 0 GO:0031430; GO:0048149; GO:0060072; GO:0040011; GO:0043050; GO:0046928; GO:0042493; GO:0045214; GO:0055120; GO:0045202; GO:0005249; GO:0008076 M band; behavioral response to ethanol; large conductance calcium-activated potassium channel activity; locomotion; pharyngeal pumping; regulation of neurotransmitter secretion; response to drug; sarcomere organization; striated muscle dense body; synapse; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR024939; IPR005821; IPR003091; IPR003929; IPR016040; Calcium-activated potassium channel slo-1 (BK channel) (Maxi K channel) (MaxiK) (Slo homolog) (Slowpoke protein 1) slo-1 Y51A2D.19 Caenorhabditis elegans TR42293_c0_g1_i1 A7E3Q8 PLST_BOVIN 0 GO:0005509; GO:0005737 calcium ion binding; cytoplasm IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; Plastin-3 (T-plastin) PLS3 Bos taurus (Bovine) TR42293_c0_g1_i2 Q63598 PLST_RAT 0 GO:0042491; GO:0005509; GO:0005737; GO:0032420 auditory receptor cell differentiation; calcium ion binding; cytoplasm; stereocilium IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; Plastin-3 (T-plastin) Pls3 Rattus norvegicus (Rat) TR42293_c0_g1_i3 A7E3Q8 PLST_BOVIN 0 GO:0005509; GO:0005737 calcium ion binding; cytoplasm IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; Plastin-3 (T-plastin) PLS3 Bos taurus (Bovine) TR42293_c0_g1_i4 Q5Z676 CML29_ORYSJ 1.00E-06 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Probable calcium-binding protein CML29 (Calmodulin-like protein 29) CML29 Os06g0691600 LOC_Os06g47640 OsJ_021585 P0532H03.18 Oryza sativa subsp. japonica (Rice) TR42295_c0_g2_i1 Q8N653 LZTR1_HUMAN 0 GO:0009653; GO:0003700 anatomical structure morphogenesis; sequence-specific DNA binding transcription factor activity IPR000210; IPR011333; IPR013069; IPR015915; IPR006652; Leucine-zipper-like transcriptional regulator 1 (LZTR-1) LZTR1 TCFL2 Homo sapiens (Human) TR42295_c0_g2_i2 P78329 CP4F2_HUMAN 2.00E-119 GO:0018685; GO:0052871; GO:0016324; GO:0008392; GO:0052869; GO:0017144; GO:0005789; GO:0019373; GO:0020037; GO:0005506; GO:0050051; GO:0030195; GO:0032304; GO:0097267; GO:0032305; GO:0003095; GO:0003091; GO:0055078; GO:0052872; GO:0000038; GO:0042360; GO:0042371; GO:0047057; GO:0006805 P16333 alkane 1-monooxygenase activity; alpha-tocopherol omega-hydroxylase activity; apical plasma membrane; arachidonic acid epoxygenase activity; arachidonic acid omega-hydroxylase activity; drug metabolic process; endoplasmic reticulum membrane; epoxygenase P450 pathway; heme binding; iron ion binding; leukotriene-B4 20-monooxygenase activity; negative regulation of blood coagulation; negative regulation of icosanoid secretion; omega-hydroxylase P450 pathway; positive regulation of icosanoid secretion; pressure natriuresis; renal water homeostasis; sodium ion homeostasis; tocotrienol omega-hydroxylase activity; very long-chain fatty acid metabolic process; vitamin E metabolic process; vitamin K biosynthetic process; vitamin-K-epoxide reductase (warfarin-sensitive) activity; xenobiotic metabolic process IPR001128; IPR017972; IPR002401; Leukotriene-B(4) omega-hydroxylase 1 (EC 1.14.13.30) (CYPIVF2) (Cytochrome P450 4F2) (Cytochrome P450-LTB-omega) (Leukotriene-B(4) 20-monooxygenase 1) CYP4F2 Homo sapiens (Human) TR42295_c0_g2_i3 Q8N653 LZTR1_HUMAN 0 GO:0009653; GO:0003700 anatomical structure morphogenesis; sequence-specific DNA binding transcription factor activity IPR000210; IPR011333; IPR013069; IPR015915; IPR006652; Leucine-zipper-like transcriptional regulator 1 (LZTR-1) LZTR1 TCFL2 Homo sapiens (Human) TR42295_c0_g2_i5 P47787 THAS_PIG 2.00E-30 GO:0005789; GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705; GO:0001516; GO:0004796 "endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; prostaglandin biosynthetic process; thromboxane-A synthase activity" IPR001128; IPR017972; IPR002401; Thromboxane-A synthase (TXA synthase) (TXS) (EC 5.3.99.5) (Cytochrome P450 5A1) TBXAS1 CYP5 CYP5A1 Sus scrofa (Pig) TR42296_c3_g1_i1 Q8WVN8 UB2Q2_HUMAN 1.00E-08 GO:0005524; GO:0005737; GO:0070936; GO:0004842 ATP binding; cytoplasm; protein K48-linked ubiquitination; ubiquitin-protein ligase activity IPR006575; IPR000608; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin carrier protein Q2) (Ubiquitin-protein ligase Q2) UBE2Q2 Homo sapiens (Human) TR42296_c3_g3_i7 Q7YQJ9 UB2Q2_RABIT 2.00E-103 GO:0005524; GO:0005737; GO:0070936; GO:0004842 ATP binding; cytoplasm; protein K48-linked ubiquitination; ubiquitin-protein ligase activity IPR000608; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin carrier protein Q2) (Ubiquitin-conjugating enzyme UBCi) (Ubiquitin-protein ligase Q2) UBE2Q2 Oryctolagus cuniculus (Rabbit) TR42300_c1_g1_i1 Q64127 TIF1A_MOUSE 2.00E-06 GO:0055074; GO:0071391; GO:0003682; GO:0005737; GO:0034056; GO:0070577; GO:0016922; GO:0008285; GO:0045892; GO:0005719; GO:0005726; GO:0045893; GO:0046777; GO:0030163; GO:0004672; GO:0042981; GO:0031647; GO:1901796; GO:0070562; GO:0043565; GO:0003713; GO:0006351; GO:0004842; GO:0008270 P83917; Q61686 "calcium ion homeostasis; cellular response to estrogen stimulus; chromatin binding; cytoplasm; estrogen response element binding; histone acetyl-lysine binding; ligand-dependent nuclear receptor binding; negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; nuclear euchromatin; perichromatin fibrils; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein catabolic process; protein kinase activity; regulation of apoptotic process; regulation of protein stability; regulation of signal transduction by p53 class mediator; regulation of vitamin D receptor signaling pathway; sequence-specific DNA binding; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR018359; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 6.3.2.-) (E3 ubiquitin-protein ligase Trim24) (Tripartite motif-containing protein 24) Trim24 Tif1 Tif1a Mus musculus (Mouse) TR42300_c1_g1_i3 Q13263 TIF1B_HUMAN 4.00E-09 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR42300_c1_g1_i6 Q5BIM1 TRI45_BOVIN 8.00E-07 GO:0005737; GO:0005634; GO:0008270 cytoplasm; nucleus; zinc ion binding IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) TR42300_c1_g1_i7 Q13263 TIF1B_HUMAN 4.00E-09 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR42301_c2_g2_i1 O13824 NMD2_SCHPO 1.00E-50 GO:0003723; GO:0005829; GO:0000184 "RNA binding; cytosol; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" IPR016024; IPR016021; IPR003890; IPR007193; Nonsense-mediated mRNA decay protein 2 (Up-frameshift suppressor 2) upf2 SPAC19A8.08 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42301_c2_g2_i2 Q9HAU5 RENT2_HUMAN 0 GO:0003723; GO:0005829; GO:0035145; GO:0010467; GO:0001889; GO:0006406; GO:0000184; GO:0031100; GO:0048471 Q96Q15; Q92900; Q9BZI7 "RNA binding; cytosol; exon-exon junction complex; gene expression; liver development; mRNA export from nucleus; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; organ regeneration; perinuclear region of cytoplasm" IPR016024; IPR016021; IPR003890; IPR007193; Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2) UPF2 KIAA1408 RENT2 Homo sapiens (Human) TR42301_c2_g2_i3 Q9HAU5 RENT2_HUMAN 0 GO:0003723; GO:0005829; GO:0035145; GO:0010467; GO:0001889; GO:0006406; GO:0000184; GO:0031100; GO:0048471 Q96Q15; Q92900; Q9BZI7 "RNA binding; cytosol; exon-exon junction complex; gene expression; liver development; mRNA export from nucleus; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; organ regeneration; perinuclear region of cytoplasm" IPR016024; IPR016021; IPR003890; IPR007193; Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2) UPF2 KIAA1408 RENT2 Homo sapiens (Human) TR42301_c2_g2_i4 O13824 NMD2_SCHPO 1.00E-50 GO:0003723; GO:0005829; GO:0000184 "RNA binding; cytosol; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" IPR016024; IPR016021; IPR003890; IPR007193; Nonsense-mediated mRNA decay protein 2 (Up-frameshift suppressor 2) upf2 SPAC19A8.08 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42302_c2_g5_i1 Q9HCF6 TRPM3_HUMAN 0 GO:0005262; GO:0005261; GO:0016021 calcium channel activity; cation channel activity; integral to membrane IPR005821; Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) TRPM3 KIAA1616 LTRPC3 Homo sapiens (Human) TR42302_c2_g5_i2 Q9HCF6 TRPM3_HUMAN 0 GO:0005262; GO:0005261; GO:0016021 calcium channel activity; cation channel activity; integral to membrane IPR005821; Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) TRPM3 KIAA1616 LTRPC3 Homo sapiens (Human) TR42304_c3_g2_i2 O14776 TCRG1_HUMAN 5.00E-137 GO:0001106; GO:0005634; GO:0003713 Q99728; P42858 RNA polymerase II transcription corepressor activity; nucleus; transcription coactivator activity IPR002713; IPR001202; Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) TCERG1 CA150 TAF2S Homo sapiens (Human) TR42305_c0_g1_i2 O55131 SEPT7_MOUSE 0 GO:0005525; GO:0043679; GO:0005938; GO:0051301; GO:0035085; GO:0060271; GO:0032154; GO:0000777; GO:0030496; GO:0007067; GO:0005634; GO:0051291; GO:0016476; GO:0031105; GO:0005819; GO:0001725; GO:0045202 GTP binding; axon terminus; cell cortex; cell division; cilium axoneme; cilium morphogenesis; cleavage furrow; condensed chromosome kinetochore; midbody; mitosis; nucleus; protein heterooligomerization; regulation of embryonic cell shape; septin complex; spindle; stress fiber; synapse IPR000038; IPR027417; IPR016491; IPR008115; Septin-7 (CDC10 protein homolog) Sept7 Cdc10 Mus musculus (Mouse) TR42305_c0_g1_i3 O55131 SEPT7_MOUSE 0 GO:0005525; GO:0043679; GO:0005938; GO:0051301; GO:0035085; GO:0060271; GO:0032154; GO:0000777; GO:0030496; GO:0007067; GO:0005634; GO:0051291; GO:0016476; GO:0031105; GO:0005819; GO:0001725; GO:0045202 GTP binding; axon terminus; cell cortex; cell division; cilium axoneme; cilium morphogenesis; cleavage furrow; condensed chromosome kinetochore; midbody; mitosis; nucleus; protein heterooligomerization; regulation of embryonic cell shape; septin complex; spindle; stress fiber; synapse IPR000038; IPR027417; IPR016491; IPR008115; Septin-7 (CDC10 protein homolog) Sept7 Cdc10 Mus musculus (Mouse) TR42306_c5_g1_i2 Q3UF64 RNFT2_MOUSE 3.00E-55 GO:0016021; GO:0008270 integral to membrane; zinc ion binding IPR001841; IPR013083; IPR017907; RING finger and transmembrane domain-containing protein 2 (Transmembrane protein 118) Rnft2 Tmem118 Mus musculus (Mouse) TR42308_c0_g1_i1 Q12965 MYO1E_HUMAN 1.00E-12 GO:0005524; GO:0042623; GO:0051015; GO:0030048; GO:0005912; GO:0005516; GO:0005911; GO:0030136; GO:0005737; GO:0006897; GO:0032836; GO:0003094; GO:0072015; GO:0001701; GO:0000146; GO:0016459; GO:0035091; GO:0048008; GO:0035166; GO:0001570 Q8N8R7; P21575; P50570; Q62910 "ATP binding; ATPase activity, coupled; actin filament binding; actin filament-based movement; adherens junction; calmodulin binding; cell-cell junction; clathrin-coated vesicle; cytoplasm; endocytosis; glomerular basement membrane development; glomerular filtration; glomerular visceral epithelial cell development; in utero embryonic development; microfilament motor activity; myosin complex; phosphatidylinositol binding; platelet-derived growth factor receptor signaling pathway; post-embryonic hemopoiesis; vasculogenesis" IPR000048; IPR001609; IPR010926; IPR027417; IPR001452; Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E) MYO1E MYO1C Homo sapiens (Human) TR42308_c0_g1_i2 Q92614 MY18A_HUMAN 0 GO:0043531; GO:0005524; GO:0003677; GO:0006259; GO:0007030; GO:0048194; GO:0051015; GO:0042641; GO:0031032; GO:0016477; GO:0005793; GO:0003774; GO:0016459; GO:0043066; GO:0050714; GO:0005802 Q9H4A6 ADP binding; ATP binding; DNA binding; DNA metabolic process; Golgi organization; Golgi vesicle budding; actin filament binding; actomyosin; actomyosin structure organization; cell migration; endoplasmic reticulum-Golgi intermediate compartment; motor activity; myosin complex; negative regulation of apoptotic process; positive regulation of protein secretion; trans-Golgi network IPR000048; IPR027401; IPR001609; IPR002928; IPR027417; IPR001478; IPR020587; Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) MYO18A KIAA0216 MYSPDZ Homo sapiens (Human) TR42308_c0_g1_i4 Q92614 MY18A_HUMAN 3.00E-177 GO:0043531; GO:0005524; GO:0003677; GO:0006259; GO:0007030; GO:0048194; GO:0051015; GO:0042641; GO:0031032; GO:0016477; GO:0005793; GO:0003774; GO:0016459; GO:0043066; GO:0050714; GO:0005802 Q9H4A6 ADP binding; ATP binding; DNA binding; DNA metabolic process; Golgi organization; Golgi vesicle budding; actin filament binding; actomyosin; actomyosin structure organization; cell migration; endoplasmic reticulum-Golgi intermediate compartment; motor activity; myosin complex; negative regulation of apoptotic process; positive regulation of protein secretion; trans-Golgi network IPR000048; IPR027401; IPR001609; IPR002928; IPR027417; IPR001478; IPR020587; Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) MYO18A KIAA0216 MYSPDZ Homo sapiens (Human) TR42309_c1_g1_i2 P56481 GASR_MOUSE 3.00E-39 GO:0048565; GO:0007204; GO:0001696; GO:0015054; GO:0048732; GO:0016021; GO:0016020; GO:0005886; GO:0008284 digestive tract development; elevation of cytosolic calcium ion concentration; gastric acid secretion; gastrin receptor activity; gland development; integral to membrane; membrane; plasma membrane; positive regulation of cell proliferation IPR009126; IPR000314; IPR000276; IPR017452; Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R) Cckbr Mus musculus (Mouse) TR42309_c1_g1_i3 P70031 CCKAR_XENLA 2.00E-40 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR009126; IPR000276; IPR017452; Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) TR42310_c1_g4_i1 Q7TNR9 ARHG4_MOUSE 7.00E-127 GO:0030676; GO:0005737; GO:0046847; GO:0035556; GO:0030032; GO:0005543; GO:0035023 Rac guanyl-nucleotide exchange factor activity; cytoplasm; filopodium assembly; intracellular signal transduction; lamellipodium assembly; phospholipid binding; regulation of Rho protein signal transduction IPR000219; IPR001331; IPR011993; IPR001849; IPR001452; Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef) Arhgef4 Kiaa1112 Mus musculus (Mouse) TR42310_c1_g4_i2 Q96N96 SPT13_HUMAN 3.00E-130 GO:0030676; GO:0016477; GO:0005737; GO:0030175; GO:0046847; GO:0030027; GO:0030032; GO:0005634; GO:0005543; GO:0035023; GO:0030334; GO:0032587 Rac guanyl-nucleotide exchange factor activity; cell migration; cytoplasm; filopodium; filopodium assembly; lamellipodium; lamellipodium assembly; nucleus; phospholipid binding; regulation of Rho protein signal transduction; regulation of cell migration; ruffle membrane IPR000219; IPR011993; IPR001849; IPR001452; Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2) SPATA13 Homo sapiens (Human) TR42310_c1_g4_i3 Q9NR80 ARHG4_HUMAN 1.00E-21 GO:0030676; GO:0097190; GO:0005829; GO:0046847; GO:0030032; GO:0048011; GO:0005543; GO:0043065; GO:0035023; GO:0051056; GO:0032587; GO:0007264 Rac guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; cytosol; filopodium assembly; lamellipodium assembly; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; ruffle membrane; small GTPase mediated signal transduction IPR000219; IPR001331; IPR011993; IPR001849; IPR001452; Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor 1) (Asef) (Asef1) ARHGEF4 KIAA1112 Homo sapiens (Human) TR42311_c3_g2_i1 O95490 LPHN2_HUMAN 6.00E-72 GO:0004930; GO:0030246; GO:0016021; GO:0016524; GO:0007218; GO:0005886 G-protein coupled receptor activity; carbohydrate binding; integral to membrane; latrotoxin receptor activity; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR001879; IPR003924; IPR003334; IPR000832; IPR017983; IPR000203; IPR000922; IPR003112; Latrophilin-2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Lectomedin-1) LPHN2 KIAA0786 LEC1 LPHH1 Homo sapiens (Human) TR42312_c4_g3_i1 Q9D8N3 TM86A_MOUSE 4.00E-30 GO:0016021 integral to membrane IPR012506; Lysoplasmalogenase-like protein TMEM86A (Transmembrane protein 86A) Tmem86a Mus musculus (Mouse) TR42313_c5_g1_i1 Q9ER30 KBTBA_RAT 2.00E-65 GO:0031463; GO:0031430; GO:0006928; GO:0005813; GO:0005856; GO:0030239; GO:0005730; GO:0005886; GO:0016567; GO:0031143; GO:0031275; GO:0045661; GO:2000291; GO:2001014; GO:0001726; GO:0035914 Cul3-RING ubiquitin ligase complex; M band; cellular component movement; centrosome; cytoskeleton; myofibril assembly; nucleolus; plasma membrane; protein ubiquitination; pseudopodium; regulation of lateral pseudopodium assembly; regulation of myoblast differentiation; regulation of myoblast proliferation; regulation of skeletal muscle cell differentiation; ruffle; skeletal muscle cell differentiation IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 41 (Kel-like protein 23) (Kelch repeat and BTB domain-containing protein 10) (Kelch-related protein 1) (Sarcosin) Klhl41 Kbtbd10 Krp1 Rattus norvegicus (Rat) TR42313_c5_g1_i2 Q5XHZ6 KLHL7_RAT 7.00E-44 GO:0031463; GO:0005730; GO:0042803; GO:0016567 Cul3-RING ubiquitin ligase complex; nucleolus; protein homodimerization activity; protein ubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 7 Klhl7 Rattus norvegicus (Rat) TR42313_c5_g1_i3 Q8CA72 GAN_MOUSE 8.00E-25 GO:0031463; GO:0008219; GO:0005737; GO:0005856; GO:0007010; GO:0016567 Cul3-RING ubiquitin ligase complex; cell death; cytoplasm; cytoskeleton; cytoskeleton organization; protein ubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Protein modification; protein ubiquitination. Gigaxonin Gan Mus musculus (Mouse) TR42313_c5_g1_i4 Q9ER30 KBTBA_RAT 9.00E-66 GO:0031463; GO:0031430; GO:0006928; GO:0005813; GO:0005856; GO:0030239; GO:0005730; GO:0005886; GO:0016567; GO:0031143; GO:0031275; GO:0045661; GO:2000291; GO:2001014; GO:0001726; GO:0035914 Cul3-RING ubiquitin ligase complex; M band; cellular component movement; centrosome; cytoskeleton; myofibril assembly; nucleolus; plasma membrane; protein ubiquitination; pseudopodium; regulation of lateral pseudopodium assembly; regulation of myoblast differentiation; regulation of myoblast proliferation; regulation of skeletal muscle cell differentiation; ruffle; skeletal muscle cell differentiation IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 41 (Kel-like protein 23) (Kelch repeat and BTB domain-containing protein 10) (Kelch-related protein 1) (Sarcosin) Klhl41 Kbtbd10 Krp1 Rattus norvegicus (Rat) TR42313_c5_g1_i5 Q2WGJ6 KLH38_HUMAN 8.00E-67 P08238 IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 38 KLHL38 C8orfK36 Homo sapiens (Human) TR42313_c5_g1_i6 Q9ER30 KBTBA_RAT 3.00E-66 GO:0031463; GO:0031430; GO:0006928; GO:0005813; GO:0005856; GO:0030239; GO:0005730; GO:0005886; GO:0016567; GO:0031143; GO:0031275; GO:0045661; GO:2000291; GO:2001014; GO:0001726; GO:0035914 Cul3-RING ubiquitin ligase complex; M band; cellular component movement; centrosome; cytoskeleton; myofibril assembly; nucleolus; plasma membrane; protein ubiquitination; pseudopodium; regulation of lateral pseudopodium assembly; regulation of myoblast differentiation; regulation of myoblast proliferation; regulation of skeletal muscle cell differentiation; ruffle; skeletal muscle cell differentiation IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 41 (Kel-like protein 23) (Kelch repeat and BTB domain-containing protein 10) (Kelch-related protein 1) (Sarcosin) Klhl41 Kbtbd10 Krp1 Rattus norvegicus (Rat) TR42314_c0_g1_i3 Q7M456 RNOY_CRAGI 2.00E-52 GO:0003723; GO:0005576; GO:0090305; GO:0033897 RNA binding; extracellular region; nucleic acid phosphodiester bond hydrolysis; ribonuclease T2 activity IPR001568; IPR018188; Ribonuclease Oy (RNase Oy) (EC 3.1.27.-) Crassostrea gigas (Pacific oyster) (Crassostrea angulata) TR42314_c0_g1_i8 Q7M456 RNOY_CRAGI 9.00E-53 GO:0003723; GO:0005576; GO:0090305; GO:0033897 RNA binding; extracellular region; nucleic acid phosphodiester bond hydrolysis; ribonuclease T2 activity IPR001568; IPR018188; Ribonuclease Oy (RNase Oy) (EC 3.1.27.-) Crassostrea gigas (Pacific oyster) (Crassostrea angulata) TR42315_c2_g3_i1 O60318 MCM3A_HUMAN 3.00E-111 GO:0003677; GO:0006260; GO:0005737; GO:0005829; GO:0005634; GO:0006606 DNA binding; DNA replication; cytoplasm; cytosol; nucleus; protein import into nucleus IPR005062; Germinal-center associated nuclear protein (GANP) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) MCM3AP GANP KIAA0572 MAP80 Homo sapiens (Human) TR42316_c1_g3_i1 O13035 SAP_CHICK 6.00E-48 GO:0005764; GO:0006665 lysosome; sphingolipid metabolic process IPR003119; IPR007856; IPR008138; IPR008373; IPR011001; IPR021165; IPR008139; Proactivator polypeptide [Cleaved into: Saposin-A; Saposin-B; Saposin-C; Saposin-D] PSAP Gallus gallus (Chicken) TR42316_c1_g3_i3 P07602 SAP_HUMAN 3.00E-37 GO:0005794; GO:0071310; GO:0008047; GO:0060742; GO:0005615; GO:0006687; GO:0016021; GO:0008289; GO:0006869; GO:0043202; GO:0005765; GO:0005739; GO:0030168; GO:0002576; GO:0060736; GO:0043408; GO:0019216; GO:0044281 Golgi apparatus; cellular response to organic substance; enzyme activator activity; epithelial cell differentiation involved in prostate gland development; extracellular space; glycosphingolipid metabolic process; integral to membrane; lipid binding; lipid transport; lysosomal lumen; lysosomal membrane; mitochondrion; platelet activation; platelet degranulation; prostate gland growth; regulation of MAPK cascade; regulation of lipid metabolic process; small molecule metabolic process IPR003119; IPR007856; IPR008138; IPR008373; IPR011001; IPR021165; IPR008139; Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)] PSAP GLBA SAP1 Homo sapiens (Human) TR42316_c1_g3_i4 O13035 SAP_CHICK 7.00E-48 GO:0005764; GO:0006665 lysosome; sphingolipid metabolic process IPR003119; IPR007856; IPR008138; IPR008373; IPR011001; IPR021165; IPR008139; Proactivator polypeptide [Cleaved into: Saposin-A; Saposin-B; Saposin-C; Saposin-D] PSAP Gallus gallus (Chicken) TR42317_c1_g10_i1 Q5BJQ6 CSTF1_RAT 2.00E-35 GO:0006397; GO:0005634 mRNA processing; nucleus IPR015943; IPR001680; IPR019775; IPR017986; Cleavage stimulation factor subunit 1 (Cleavage stimulation factor 50 kDa subunit) (CSTF 50 kDa subunit) (CstF-50) Cstf1 Rattus norvegicus (Rat) TR42317_c1_g5_i1 Q8YRI1 YY46_NOSS1 3.00E-20 GO:0006355 "regulation of transcription, DNA-dependent" IPR001646; IPR020472; IPR007111; IPR027417; IPR011047; IPR027728; IPR015943; IPR001680; IPR019775; IPR017986; Uncharacterized WD repeat-containing protein alr3466 alr3466 Nostoc sp. (strain PCC 7120 / UTEX 2576) TR42317_c1_g5_i2 Q09715 TUP11_SCHPO 1.00E-17 GO:0006342; GO:0005829; GO:0042393; GO:0045014; GO:0000122; GO:0000790; GO:0043234; GO:0003714; GO:0006351 "chromatin silencing; cytosol; histone binding; negative regulation of transcription by glucose; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; protein complex; transcription corepressor activity; transcription, DNA-dependent" IPR020472; IPR013890; IPR015943; IPR001680; IPR019775; IPR017986; Transcriptional repressor tup11 tup11 SPAC18B11.10 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42317_c1_g5_i3 Q5BJQ6 CSTF1_RAT 0 GO:0006397; GO:0005634 mRNA processing; nucleus IPR015943; IPR001680; IPR019775; IPR017986; Cleavage stimulation factor subunit 1 (Cleavage stimulation factor 50 kDa subunit) (CSTF 50 kDa subunit) (CstF-50) Cstf1 Rattus norvegicus (Rat) TR42317_c1_g5_i4 Q54KL5 WDR5_DICDI 1.00E-22 GO:0051568; GO:0042393; GO:0035097 histone H3-K4 methylation; histone binding; histone methyltransferase complex IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 5 homolog wdr5 DDB_G0287273 Dictyostelium discoideum (Slime mold) TR42318_c1_g1_i1 Q16831 UPP1_HUMAN 4.00E-94 GO:0044206; GO:0042149; GO:0005829; GO:0009166; GO:0006206; GO:0046135; GO:0043097; GO:0046108; GO:0004850 UMP salvage; cellular response to glucose starvation; cytosol; nucleotide catabolic process; pyrimidine nucleobase metabolic process; pyrimidine nucleoside catabolic process; pyrimidine nucleoside salvage; uridine metabolic process; uridine phosphorylase activity IPR018017; IPR018016; IPR000845; IPR010059; Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1. Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3) UPP1 UP Homo sapiens (Human) TR42318_c1_g1_i2 O95045 UPP2_HUMAN 1.00E-97 GO:0044206; GO:0005829; GO:0009166; GO:0006206; GO:0046135; GO:0043097; GO:0045098; GO:0046108; GO:0004850 UMP salvage; cytosol; nucleotide catabolic process; pyrimidine nucleobase metabolic process; pyrimidine nucleoside catabolic process; pyrimidine nucleoside salvage; type III intermediate filament; uridine metabolic process; uridine phosphorylase activity IPR018017; IPR018016; IPR000845; IPR010059; Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1. Uridine phosphorylase 2 (UPase 2) (UrdPase 2) (EC 2.4.2.3) UPP2 Homo sapiens (Human) TR42318_c1_g1_i7 O95045 UPP2_HUMAN 3.00E-97 GO:0044206; GO:0005829; GO:0009166; GO:0006206; GO:0046135; GO:0043097; GO:0045098; GO:0046108; GO:0004850 UMP salvage; cytosol; nucleotide catabolic process; pyrimidine nucleobase metabolic process; pyrimidine nucleoside catabolic process; pyrimidine nucleoside salvage; type III intermediate filament; uridine metabolic process; uridine phosphorylase activity IPR018017; IPR018016; IPR000845; IPR010059; Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1. Uridine phosphorylase 2 (UPase 2) (UrdPase 2) (EC 2.4.2.3) UPP2 Homo sapiens (Human) TR42318_c1_g1_i8 O95045 UPP2_HUMAN 1.00E-97 GO:0044206; GO:0005829; GO:0009166; GO:0006206; GO:0046135; GO:0043097; GO:0045098; GO:0046108; GO:0004850 UMP salvage; cytosol; nucleotide catabolic process; pyrimidine nucleobase metabolic process; pyrimidine nucleoside catabolic process; pyrimidine nucleoside salvage; type III intermediate filament; uridine metabolic process; uridine phosphorylase activity IPR018017; IPR018016; IPR000845; IPR010059; Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1. Uridine phosphorylase 2 (UPase 2) (UrdPase 2) (EC 2.4.2.3) UPP2 Homo sapiens (Human) TR42319_c1_g1_i1 P19526 FUT1_HUMAN 6.00E-27 GO:0005794; GO:0032580; GO:0042355; GO:0008107; GO:0005887; GO:0006486 Golgi apparatus; Golgi cisterna membrane; L-fucose catabolic process; galactoside 2-alpha-L-fucosyltransferase activity; integral to plasma membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha(1,2)FT 1) (Blood group H alpha 2-fucosyltransferase) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" FUT1 H HSC Homo sapiens (Human) TR42319_c1_g1_i6 Q9TUD6 FUT1_PANTR 6.00E-25 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" FUT1 Pan troglodytes (Chimpanzee) TR42319_c1_g1_i7 Q9TUD6 FUT1_PANTR 3.00E-27 GO:0032580; GO:0008107; GO:0016021; GO:0006486 Golgi cisterna membrane; galactoside 2-alpha-L-fucosyltransferase activity; integral to membrane; protein glycosylation IPR002516; Protein modification; protein glycosylation. "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" FUT1 Pan troglodytes (Chimpanzee) TR42320_c1_g1_i2 Q00536 CDK16_HUMAN 8.00E-97 GO:0005524; GO:0030054; GO:0004693; GO:0005737; GO:0006887; GO:0031234; GO:0030252; GO:0043005; GO:0031175; GO:0004674; GO:0061178; GO:0007283; GO:0008021; GO:0030133 Q15436 ATP binding; cell junction; cyclin-dependent protein serine/threonine kinase activity; cytoplasm; exocytosis; extrinsic to internal side of plasma membrane; growth hormone secretion; neuron projection; neuron projection development; protein serine/threonine kinase activity; regulation of insulin secretion involved in cellular response to glucose stimulus; spermatogenesis; synaptic vesicle; transport vesicle IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) CDK16 PCTAIRE1 PCTK1 Homo sapiens (Human) TR42320_c1_g1_i4 P51958 CDK1_CARAU 1.00E-173 GO:0005524; GO:0008353; GO:0051301; GO:0004693; GO:0005737; GO:0005815; GO:0007067; GO:0005634 ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; cell division; cyclin-dependent protein serine/threonine kinase activity; cytoplasm; microtubule organizing center; mitosis; nucleus IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) cdk1 cdc2 Carassius auratus (Goldfish) TR42321_c1_g1_i1 O95164 UBL3_HUMAN 2.00E-41 GO:0005622; GO:0005886 intracellular; plasma membrane IPR017000; IPR000626; Ubiquitin-like protein 3 (Membrane-anchored ubiquitin-fold protein) (HsMUB) (MUB) (Protein HCG-1) UBL3 PNSC1 Homo sapiens (Human) TR42321_c5_g1_i1 Q63871 RPAB4_MOUSE 4.00E-26 GO:0003677; GO:0005736; GO:0005665; GO:0005666; GO:0003899; GO:0046872; GO:0006366 "DNA binding; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase activity; metal ion binding; transcription from RNA polymerase II promoter" IPR006591; "DNA-directed RNA polymerases I, II, and III subunit RPABC4 (RNA polymerases I, II, and III subunit ABC4) (DNA-directed RNA polymerase II subunit K) (Metallothionein-I gene transcription activator) (RPB10alpha)" Polr2k Mt1a Mus musculus (Mouse) TR42322_c0_g1_i2 Q9P2K3 RCOR3_HUMAN 3.00E-113 GO:0003677; GO:0003682; GO:0005634; GO:0006355; GO:0006351 Q14687; P19012 "DNA binding; chromatin binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000949; IPR009057; IPR001005; IPR017884; REST corepressor 3 RCOR3 KIAA1343 Homo sapiens (Human) TR42322_c0_g1_i3 Q6P116 RCOR2_DANRE 4.00E-113 GO:0003677; GO:0003682; GO:0005634; GO:0006355; GO:0006351 "DNA binding; chromatin binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000949; IPR009057; IPR001005; IPR017884; REST corepressor 2 rcor2 zgc:77264 Danio rerio (Zebrafish) (Brachydanio rerio) TR42322_c0_g1_i4 Q9P2K3 RCOR3_HUMAN 3.00E-113 GO:0003677; GO:0003682; GO:0005634; GO:0006355; GO:0006351 Q14687; P19012 "DNA binding; chromatin binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000949; IPR009057; IPR001005; IPR017884; REST corepressor 3 RCOR3 KIAA1343 Homo sapiens (Human) TR42322_c0_g1_i5 Q5REE1 MIER1_PONAB 9.00E-06 GO:0003677; GO:0003682; GO:0031937; GO:0006351; GO:0017053 "DNA binding; chromatin binding; positive regulation of chromatin silencing; transcription, DNA-dependent; transcriptional repressor complex" IPR000949; IPR009057; IPR001005; IPR017884; Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) MIER1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42322_c0_g1_i7 Q6P116 RCOR2_DANRE 2.00E-114 GO:0003677; GO:0003682; GO:0005634; GO:0006355; GO:0006351 "DNA binding; chromatin binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000949; IPR009057; IPR001005; IPR017884; REST corepressor 2 rcor2 zgc:77264 Danio rerio (Zebrafish) (Brachydanio rerio) TR42322_c0_g1_i8 Q9P2K3 RCOR3_HUMAN 1.00E-118 GO:0003677; GO:0003682; GO:0005634; GO:0006355; GO:0006351 Q14687; P19012 "DNA binding; chromatin binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000949; IPR009057; IPR001005; IPR017884; REST corepressor 3 RCOR3 KIAA1343 Homo sapiens (Human) TR42323_c0_g2_i1 Q15155 NOMO1_HUMAN 0 GO:0030246; GO:0016021 carbohydrate binding; integral to membrane IPR013784; IPR008969; IPR014766; IPR013783; Nodal modulator 1 (pM5 protein) NOMO1 PM5 Homo sapiens (Human) TR42325_c1_g3_i1 Q4R4I6 CAP1_MACFA 1.00E-137 GO:0000902; GO:0007010; GO:0005886 cell morphogenesis; cytoskeleton organization; plasma membrane IPR001837; IPR013912; IPR013992; IPR017901; IPR016098; IPR018106; IPR006599; Adenylyl cyclase-associated protein 1 (CAP 1) CAP1 QtrA-13003 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR42325_c1_g3_i4 Q9CYT6 CAP2_MOUSE 1.00E-93 GO:0000902; GO:0007010; GO:0005886 cell morphogenesis; cytoskeleton organization; plasma membrane IPR001837; IPR013912; IPR013992; IPR017901; IPR016098; IPR018106; IPR006599; Adenylyl cyclase-associated protein 2 (CAP 2) Cap2 Mus musculus (Mouse) TR42325_c1_g3_i5 Q4R4I6 CAP1_MACFA 2.00E-135 GO:0000902; GO:0007010; GO:0005886 cell morphogenesis; cytoskeleton organization; plasma membrane IPR001837; IPR013912; IPR013992; IPR017901; IPR016098; IPR018106; IPR006599; Adenylyl cyclase-associated protein 1 (CAP 1) CAP1 QtrA-13003 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR42325_c1_g3_i8 Q4R4I6 CAP1_MACFA 1.00E-135 GO:0000902; GO:0007010; GO:0005886 cell morphogenesis; cytoskeleton organization; plasma membrane IPR001837; IPR013912; IPR013992; IPR017901; IPR016098; IPR018106; IPR006599; Adenylyl cyclase-associated protein 1 (CAP 1) CAP1 QtrA-13003 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR42326_c1_g2_i1 Q0J649 COPD4_ORYSJ 2.00E-32 GO:0030126; GO:0030131; GO:0006886; GO:0006890 "COPI vesicle coat; clathrin adaptor complex; intracellular protein transport; retrograde vesicle-mediated transport, Golgi to ER" IPR008968; IPR027059; Coatomer subunit delta-4 (Delta-coat protein 4) (Delta-COP 4) Os08g0368000 LOC_Os08g28080 Oryza sativa subsp. japonica (Rice) TR42326_c1_g3_i1 Q5ZL57 COPD_CHICK 8.00E-97 GO:0030126; GO:0008344; GO:0021691; GO:0030131; GO:0005783; GO:0006886; GO:0043473; GO:0006890 "COPI vesicle coat; adult locomotory behavior; cerebellar Purkinje cell layer maturation; clathrin adaptor complex; endoplasmic reticulum; intracellular protein transport; pigmentation; retrograde vesicle-mediated transport, Golgi to ER" IPR022775; IPR008968; IPR027059; IPR011012; Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) ARCN1 COPD RCJMB04_7j3 Gallus gallus (Chicken) TR42326_c1_g3_i2 Q5ZL57 COPD_CHICK 9.00E-97 GO:0030126; GO:0008344; GO:0021691; GO:0030131; GO:0005783; GO:0006886; GO:0043473; GO:0006890 "COPI vesicle coat; adult locomotory behavior; cerebellar Purkinje cell layer maturation; clathrin adaptor complex; endoplasmic reticulum; intracellular protein transport; pigmentation; retrograde vesicle-mediated transport, Golgi to ER" IPR022775; IPR008968; IPR027059; IPR011012; Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) ARCN1 COPD RCJMB04_7j3 Gallus gallus (Chicken) TR42326_c1_g6_i1 Q0J649 COPD4_ORYSJ 3.00E-11 GO:0030126; GO:0030131; GO:0006886; GO:0006890 "COPI vesicle coat; clathrin adaptor complex; intracellular protein transport; retrograde vesicle-mediated transport, Golgi to ER" IPR008968; IPR027059; Coatomer subunit delta-4 (Delta-coat protein 4) (Delta-COP 4) Os08g0368000 LOC_Os08g28080 Oryza sativa subsp. japonica (Rice) TR42327_c0_g2_i2 Q99315 YG31B_YEAST 2.00E-45 GO:0005524; GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0005737; GO:0008233; GO:0006508; GO:0000943; GO:0004523; GO:0004540; GO:0032197; GO:0046797; GO:0008270 "ATP binding; DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; cytoplasm; peptidase activity; proteolysis; retrotransposon nucleocapsid; ribonuclease H activity; ribonuclease activity; transposition, RNA-mediated; viral procapsid maturation; zinc ion binding" IPR001584; IPR024650; IPR021109; IPR005162; IPR012337; IPR000477; IPR001878; Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42327_c0_g3_i1 P03365 POL_MMTVB 3.00E-09 GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0075713; GO:0090305; GO:0004523; GO:0046718; GO:0008270 DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; establishment of integrated proviral latency; nucleic acid phosphodiester bond hydrolysis; ribonuclease H activity; viral entry into host cell; zinc ion binding IPR001037; IPR001584; IPR017856; IPR003308; IPR012337; IPR002156; IPR000477; IPR010661; Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN)] pol Mouse mammary tumor virus (strain BR6) (MMTV) TR42327_c0_g3_i2 Q09575 YRD6_CAEEL 4.00E-39 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR42329_c2_g1_i10 P32882 TBB2_CHICK 0 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR013838; IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta-2 chain (Beta-tubulin class-II) Gallus gallus (Chicken) TR42329_c2_g1_i2 P32882 TBB2_CHICK 0 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR013838; IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta-2 chain (Beta-tubulin class-II) Gallus gallus (Chicken) TR42329_c2_g1_i3 P02556 TBB_LYTPI 5.00E-102 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; Tubulin beta chain (Beta-tubulin) (Fragment) Lytechinus pictus (Painted sea urchin) TR42329_c2_g1_i6 P18699 TBB_LYMST 8.00E-52 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; Tubulin beta chain (Beta-tubulin) (Fragment) Lymnaea stagnalis (Great pond snail) TR42329_c2_g1_i8 Q9D6T1 TBE_MOUSE 2.00E-64 GO:0005525; GO:0003924; GO:0051297; GO:0005874; GO:0000242; GO:0051258 GTP binding; GTPase activity; centrosome organization; microtubule; pericentriolar material; protein polymerization IPR004057; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin epsilon chain (Epsilon-tubulin) Tube1 Mus musculus (Mouse) TR42329_c2_g1_i9 P02556 TBB_LYTPI 4.00E-102 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; Tubulin beta chain (Beta-tubulin) (Fragment) Lytechinus pictus (Painted sea urchin) TR42330_c0_g1_i1 Q96T76 MMS19_HUMAN 5.00E-176 GO:0097361; GO:0071817; GO:0007059; GO:0005675; GO:0016226; GO:0006289; GO:0000160; GO:0045893; GO:0030674; GO:0030159; GO:0009725; GO:0044281; GO:0003713; GO:0006351 "CIA complex; MMXD complex; chromosome segregation; holo TFIIH complex; iron-sulfur cluster assembly; nucleotide-excision repair; phosphorelay signal transduction system; positive regulation of transcription, DNA-dependent; protein binding, bridging; receptor signaling complex scaffold activity; response to hormone stimulus; small molecule metabolic process; transcription coactivator activity; transcription, DNA-dependent" IPR011989; IPR016024; IPR024687; MMS19 nucleotide excision repair protein homolog (hMMS19) (MET18 homolog) (MMS19-like protein) MMS19 MMS19L Homo sapiens (Human) TR42333_c0_g2_i1 P55277 VATL_HELVI 1.00E-64 GO:0015991; GO:0015078; GO:0016021; GO:0033179; GO:0005774 "ATP hydrolysis coupled proton transport; hydrogen ion transmembrane transporter activity; integral to membrane; proton-transporting V-type ATPase, V0 domain; vacuolar membrane" IPR002379; IPR000245; IPR011555; V-type proton ATPase 16 kDa proteolipid subunit (V-ATPase 16 kDa proteolipid subunit) (Vacuolar proton pump 16 kDa proteolipid subunit) VHA16 Heliothis virescens (Tobacco budworm moth) TR42333_c0_g2_i4 P55277 VATL_HELVI 4.00E-66 GO:0015991; GO:0015078; GO:0016021; GO:0033179; GO:0005774 "ATP hydrolysis coupled proton transport; hydrogen ion transmembrane transporter activity; integral to membrane; proton-transporting V-type ATPase, V0 domain; vacuolar membrane" IPR002379; IPR000245; IPR011555; V-type proton ATPase 16 kDa proteolipid subunit (V-ATPase 16 kDa proteolipid subunit) (Vacuolar proton pump 16 kDa proteolipid subunit) VHA16 Heliothis virescens (Tobacco budworm moth) TR42334_c0_g1_i1 O57579 AMPN_CHICK 0 GO:0004177; GO:0016021; GO:0008237; GO:0005886; GO:0006508; GO:0008270 aminopeptidase activity; integral to membrane; metallopeptidase activity; plasma membrane; proteolysis; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (EC 3.4.11.2) (Aminopeptidase Ey) (EC 3.4.11.20) ANPEP APDE Gallus gallus (Chicken) TR42334_c0_g1_i2 P24527 LKHA4_MOUSE 1.00E-08 GO:0004177; GO:0005737; GO:0004301; GO:0019370; GO:0004463; GO:0008237; GO:0005634; GO:0043171; GO:0006508; GO:0008270 aminopeptidase activity; cytoplasm; epoxide hydrolase activity; leukotriene biosynthetic process; leukotriene-A4 hydrolase activity; metallopeptidase activity; nucleus; peptide catabolic process; proteolysis; zinc ion binding IPR016024; IPR012777; IPR001930; IPR015211; IPR014782; Lipid metabolism; leukotriene B4 biosynthesis. Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) Lta4h Mus musculus (Mouse) TR42334_c0_g1_i3 P15145 AMPN_PIG 0 GO:0004177; GO:0001525; GO:0030154; GO:0016021; GO:0008237; GO:0019048; GO:0006508; GO:0009615; GO:0001618; GO:0008270 aminopeptidase activity; angiogenesis; cell differentiation; integral to membrane; metallopeptidase activity; modulation by virus of host morphology or physiology; proteolysis; response to virus; virus receptor activity; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (AP-N) (pAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (gp130) (CD antigen CD13) ANPEP Sus scrofa (Pig) TR42334_c0_g1_i4 O57579 AMPN_CHICK 0 GO:0004177; GO:0016021; GO:0008237; GO:0005886; GO:0006508; GO:0008270 aminopeptidase activity; integral to membrane; metallopeptidase activity; plasma membrane; proteolysis; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (EC 3.4.11.2) (Aminopeptidase Ey) (EC 3.4.11.20) ANPEP APDE Gallus gallus (Chicken) TR42334_c0_g1_i5 P50123 AMPE_RAT 0 GO:0016477; GO:0008283; GO:0006725; GO:0016021; GO:0070006; GO:0042277; GO:0006508; GO:0003081; GO:0031983; GO:0012506; GO:0008270 cell migration; cell proliferation; cellular aromatic compound metabolic process; integral to membrane; metalloaminopeptidase activity; peptide binding; proteolysis; regulation of systemic arterial blood pressure by renin-angiotensin; vesicle lumen; vesicle membrane; zinc ion binding IPR024571; IPR001930; IPR014782; Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (CD antigen CD249) Enpep Rattus norvegicus (Rat) TR42334_c0_g1_i6 P15541 AMPN_RABIT 0 GO:0004177; GO:0001525; GO:0030154; GO:0016021; GO:0008237; GO:0005886; GO:0006508; GO:0008270 aminopeptidase activity; angiogenesis; cell differentiation; integral to membrane; metallopeptidase activity; plasma membrane; proteolysis; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (AP-N) (rbAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) ANPEP Oryctolagus cuniculus (Rabbit) TR42334_c0_g1_i7 O57579 AMPN_CHICK 0 GO:0004177; GO:0016021; GO:0008237; GO:0005886; GO:0006508; GO:0008270 aminopeptidase activity; integral to membrane; metallopeptidase activity; plasma membrane; proteolysis; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (EC 3.4.11.2) (Aminopeptidase Ey) (EC 3.4.11.20) ANPEP APDE Gallus gallus (Chicken) TR42334_c0_g1_i8 P79098 AMPN_BOVIN 0 GO:0004177; GO:0001525; GO:0030154; GO:0016021; GO:0008237; GO:0006508; GO:0009615; GO:0001618; GO:0008270 aminopeptidase activity; angiogenesis; cell differentiation; integral to membrane; metallopeptidase activity; proteolysis; response to virus; virus receptor activity; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (AP-N) (bAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) ANPEP APN Bos taurus (Bovine) TR42334_c0_g1_i9 Q9NZ08 ERAP1_HUMAN 4.00E-165 GO:0004177; GO:0001525; GO:0019885; GO:0005829; GO:0005788; GO:0005789; GO:0005576; GO:0045444; GO:0016021; GO:0005151; GO:0006509; GO:0008235; GO:0045766; GO:0008217; GO:0045088; GO:0009617; GO:0008270 P08887 "aminopeptidase activity; angiogenesis; antigen processing and presentation of endogenous peptide antigen via MHC class I; cytosol; endoplasmic reticulum lumen; endoplasmic reticulum membrane; extracellular region; fat cell differentiation; integral to membrane; interleukin-1, Type II receptor binding; membrane protein ectodomain proteolysis; metalloexopeptidase activity; positive regulation of angiogenesis; regulation of blood pressure; regulation of innate immune response; response to bacterium; zinc ion binding" IPR024571; IPR001930; IPR014782; Endoplasmic reticulum aminopeptidase 1 (EC 3.4.11.-) (ARTS-1) (Adipocyte-derived leucine aminopeptidase) (A-LAP) (Aminopeptidase PILS) (Puromycin-insensitive leucyl-specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator) ERAP1 APPILS ARTS1 KIAA0525 UNQ584/PRO1154 Homo sapiens (Human) TR42335_c0_g1_i1 Q27968 DNJC3_BOVIN 1.00E-139 GO:0005783; GO:0006986 P19525 endoplasmic reticulum; response to unfolded protein IPR001623; IPR026901; IPR013026; IPR011990; IPR001440; IPR019734; "DnaJ homolog subfamily C member 3 (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58)" DNAJC3 P58IPK Bos taurus (Bovine) TR42335_c0_g1_i2 Q86TZ1 TTC6_HUMAN 6.00E-10 IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 6 (TPR repeat protein 6) TTC6 Homo sapiens (Human) TR42335_c0_g1_i3 Q9QYI5 DNJB2_MOUSE 1.00E-10 GO:0030433; GO:0016234; GO:0030308; GO:0008285; GO:0090084; GO:0090086; GO:0032436; GO:0031398; GO:0000502 ER-associated protein catabolic process; inclusion body; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of inclusion body assembly; negative regulation of protein deubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; proteasome complex IPR001623; IPR018253; IPR003903; DnaJ homolog subfamily B member 2 (DnaJ homolog subfamily B member 10) (mDj8) Dnajb2 Dnajb10 Mus musculus (Mouse) TR42336_c3_g2_i1 Q9BYW2 SETD2_HUMAN 7.00E-107 GO:0001525; GO:0035441; GO:0005694; GO:0060977; GO:0048701; GO:0060669; GO:0030900; GO:0097198; GO:0018024; GO:0048332; GO:0006298; GO:0001763; GO:0001843; GO:0034728; GO:0005634; GO:0060039; GO:0010793; GO:0006355; GO:0048864; GO:0006368 P84022 "angiogenesis; cell migration involved in vasculogenesis; chromosome; coronary vasculature morphogenesis; embryonic cranial skeleton morphogenesis; embryonic placenta morphogenesis; forebrain development; histone H3-K36 trimethylation; histone-lysine N-methyltransferase activity; mesoderm morphogenesis; mismatch repair; morphogenesis of a branching structure; neural tube closure; nucleosome organization; nucleus; pericardium development; regulation of mRNA export from nucleus; regulation of transcription, DNA-dependent; stem cell development; transcription elongation from RNA polymerase II promoter" IPR006560; IPR003616; IPR001214; IPR013257; IPR001202; Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.43) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (SET domain-containing protein 2) (hSET2) (p231HBP) SETD2 HIF1 HYPB KIAA1732 KMT3A SET2 HSPC069 Homo sapiens (Human) TR42336_c3_g2_i2 Q9BYW2 SETD2_HUMAN 1.00E-107 GO:0001525; GO:0035441; GO:0005694; GO:0060977; GO:0048701; GO:0060669; GO:0030900; GO:0097198; GO:0018024; GO:0048332; GO:0006298; GO:0001763; GO:0001843; GO:0034728; GO:0005634; GO:0060039; GO:0010793; GO:0006355; GO:0048864; GO:0006368 P84022 "angiogenesis; cell migration involved in vasculogenesis; chromosome; coronary vasculature morphogenesis; embryonic cranial skeleton morphogenesis; embryonic placenta morphogenesis; forebrain development; histone H3-K36 trimethylation; histone-lysine N-methyltransferase activity; mesoderm morphogenesis; mismatch repair; morphogenesis of a branching structure; neural tube closure; nucleosome organization; nucleus; pericardium development; regulation of mRNA export from nucleus; regulation of transcription, DNA-dependent; stem cell development; transcription elongation from RNA polymerase II promoter" IPR006560; IPR003616; IPR001214; IPR013257; IPR001202; Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.43) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (SET domain-containing protein 2) (hSET2) (p231HBP) SETD2 HIF1 HYPB KIAA1732 KMT3A SET2 HSPC069 Homo sapiens (Human) TR42336_c3_g2_i7 Q9BYW2 SETD2_HUMAN 4.00E-16 GO:0001525; GO:0035441; GO:0005694; GO:0060977; GO:0048701; GO:0060669; GO:0030900; GO:0097198; GO:0018024; GO:0048332; GO:0006298; GO:0001763; GO:0001843; GO:0034728; GO:0005634; GO:0060039; GO:0010793; GO:0006355; GO:0048864; GO:0006368 P84022 "angiogenesis; cell migration involved in vasculogenesis; chromosome; coronary vasculature morphogenesis; embryonic cranial skeleton morphogenesis; embryonic placenta morphogenesis; forebrain development; histone H3-K36 trimethylation; histone-lysine N-methyltransferase activity; mesoderm morphogenesis; mismatch repair; morphogenesis of a branching structure; neural tube closure; nucleosome organization; nucleus; pericardium development; regulation of mRNA export from nucleus; regulation of transcription, DNA-dependent; stem cell development; transcription elongation from RNA polymerase II promoter" IPR006560; IPR003616; IPR001214; IPR013257; IPR001202; Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.43) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (SET domain-containing protein 2) (hSET2) (p231HBP) SETD2 HIF1 HYPB KIAA1732 KMT3A SET2 HSPC069 Homo sapiens (Human) TR42337_c0_g3_i10 Q6P4A8 PLBL1_HUMAN 1.00E-169 GO:0005829; GO:0005576; GO:0046474; GO:0016787; GO:0016042; GO:0036151; GO:0036152; GO:0036149 cytosol; extracellular region; glycerophospholipid biosynthetic process; hydrolase activity; lipid catabolic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylinositol acyl-chain remodeling IPR007000; Phospholipase B-like 1 (EC 3.1.1.-) (LAMA-like protein 1) (Lamina ancestor homolog 1) (Phospholipase B domain-containing protein 1) PLBD1 Homo sapiens (Human) TR42337_c0_g3_i11 Q8VCI0 PLBL1_MOUSE 2.00E-163 GO:0005576; GO:0016787; GO:0016042 extracellular region; hydrolase activity; lipid catabolic process IPR007000; Phospholipase B-like 1 (EC 3.1.1.-) (LAMA-like protein 1) (Lamina ancestor homolog 1) (Phospholipase B domain-containing protein 1) Plbd1 Mus musculus (Mouse) TR42337_c0_g3_i4 Q6P4A8 PLBL1_HUMAN 2.00E-169 GO:0005829; GO:0005576; GO:0046474; GO:0016787; GO:0016042; GO:0036151; GO:0036152; GO:0036149 cytosol; extracellular region; glycerophospholipid biosynthetic process; hydrolase activity; lipid catabolic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylinositol acyl-chain remodeling IPR007000; Phospholipase B-like 1 (EC 3.1.1.-) (LAMA-like protein 1) (Lamina ancestor homolog 1) (Phospholipase B domain-containing protein 1) PLBD1 Homo sapiens (Human) TR42337_c0_g3_i9 Q9GL30 PLBL1_BOVIN 2.00E-168 GO:0005576; GO:0016787; GO:0016042 extracellular region; hydrolase activity; lipid catabolic process IPR007000; Phospholipase B-like 1 (EC 3.1.1.-) (LAMA-like protein 1) (Lamina ancestor homolog 1) (Phospholipase B domain-containing protein 1) PLBD1 Bos taurus (Bovine) TR42338_c0_g2_i4 Q726P7 FTSY_DESVH 1.00E-34 GO:0005525; GO:0003924; GO:0006614; GO:0005737; GO:0031226 GTP binding; GTPase activity; SRP-dependent cotranslational protein targeting to membrane; cytoplasm; intrinsic to plasma membrane IPR003593; IPR027417; IPR013822; IPR004390; IPR000897; Signal recognition particle receptor FtsY (SRP receptor) ftsY DVU_3059 Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) TR42338_c0_g2_i6 O80842 CFTSY_ARATH 1.00E-32 GO:0005525; GO:0006184; GO:0006614; GO:0009570; GO:0009535; GO:0046872; GO:0017111 Q8LBP4 GTP binding; GTP catabolic process; SRP-dependent cotranslational protein targeting to membrane; chloroplast stroma; chloroplast thylakoid membrane; metal ion binding; nucleoside-triphosphatase activity IPR003593; IPR027417; IPR013822; IPR004390; IPR000897; "Cell division protein FtsY homolog, chloroplastic (Chloroplast SRP receptor homolog, alpha subunit CpFtsY) (Fused signal recognition particle receptor)" CPFTSY FTSY At2g45770 F4I18.25 Arabidopsis thaliana (Mouse-ear cress) TR42338_c0_g2_i7 P14576 SRP54_MOUSE 0 GO:0008312; GO:0005525; GO:0006184; GO:0003924; GO:0006614; GO:0016607; GO:0005786 "7S RNA binding; GTP binding; GTP catabolic process; GTPase activity; SRP-dependent cotranslational protein targeting to membrane; nuclear speck; signal recognition particle, endoplasmic reticulum targeting" IPR003593; IPR027417; IPR013822; IPR004125; IPR022941; IPR006325; IPR000897; Signal recognition particle 54 kDa protein (SRP54) Srp54 Mus musculus (Mouse) TR42338_c0_g2_i8 P32916 SRPR_YEAST 1.00E-19 GO:0005525; GO:0006614; GO:0017111; GO:0005047; GO:0005785 P36057 GTP binding; SRP-dependent cotranslational protein targeting to membrane; nucleoside-triphosphatase activity; signal recognition particle binding; signal recognition particle receptor complex IPR003593; IPR011012; IPR027417; IPR015284; IPR013822; IPR000897; Signal recognition particle receptor subunit alpha homolog (SR-alpha) (Docking protein alpha) (DP-alpha) SRP101 YDR292C D9819.3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42338_c0_g2_i9 P14576 SRP54_MOUSE 0 GO:0008312; GO:0005525; GO:0006184; GO:0003924; GO:0006614; GO:0016607; GO:0005786 "7S RNA binding; GTP binding; GTP catabolic process; GTPase activity; SRP-dependent cotranslational protein targeting to membrane; nuclear speck; signal recognition particle, endoplasmic reticulum targeting" IPR003593; IPR027417; IPR013822; IPR004125; IPR022941; IPR006325; IPR000897; Signal recognition particle 54 kDa protein (SRP54) Srp54 Mus musculus (Mouse) TR42339_c1_g2_i1 Q0III6 DNJB6_BOVIN 3.00E-40 GO:0030018; GO:0005634; GO:0048471 Z disc; nucleus; perinuclear region of cytoplasm IPR001623; IPR018253; DnaJ homolog subfamily B member 6 (MRJ) DNAJB6 MRJ Bos taurus (Bovine) TR42339_c1_g2_i2 Q7Z6W7 DNJB7_HUMAN 2.00E-28 IPR001623; IPR018253; DnaJ homolog subfamily B member 7 DNAJB7 HSC3 Homo sapiens (Human) TR42339_c1_g2_i3 Q0III6 DNJB6_BOVIN 3.00E-40 GO:0030018; GO:0005634; GO:0048471 Z disc; nucleus; perinuclear region of cytoplasm IPR001623; IPR018253; DnaJ homolog subfamily B member 6 (MRJ) DNAJB6 MRJ Bos taurus (Bovine) TR42339_c1_g2_i4 Q9QYI8 DNJB7_MOUSE 8.00E-27 IPR001623; IPR018253; DnaJ homolog subfamily B member 7 (mDj5) Dnajb7 Mus musculus (Mouse) TR42339_c1_g2_i9 Q7Z6W7 DNJB7_HUMAN 6.00E-30 IPR001623; IPR018253; DnaJ homolog subfamily B member 7 DNAJB7 HSC3 Homo sapiens (Human) TR42340_c0_g1_i1 Q62761 KC1G1_RAT 4.00E-123 GO:0005524; GO:0016055; GO:0005737; GO:0001948; GO:0000287; GO:0042277; GO:0051219; GO:0046777; GO:0004674 ATP binding; Wnt receptor signaling pathway; cytoplasm; glycoprotein binding; magnesium ion binding; peptide binding; phosphoprotein binding; protein autophosphorylation; protein serine/threonine kinase activity IPR022247; IPR011009; IPR000719; IPR017441; IPR008271; Casein kinase I isoform gamma-1 (CKI-gamma 1) (EC 2.7.11.1) Csnk1g1 Rattus norvegicus (Rat) TR42340_c0_g1_i3 Q6P3K7 KC1DB_DANRE 0 GO:0005524; GO:0016055; GO:0005737; GO:0005634; GO:0004674 ATP binding; Wnt receptor signaling pathway; cytoplasm; nucleus; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Casein kinase I isoform delta-B (CKI-delta-B) (CKId-B) (EC 2.7.11.1) csnk1db Danio rerio (Zebrafish) (Brachydanio rerio) TR42343_c4_g2_i2 P52209 6PGD_HUMAN 0 GO:0019521; GO:0050661; GO:0005829; GO:0019322; GO:0009051; GO:0004616 O95777 "D-gluconate metabolic process; NADP binding; cytosol; pentose biosynthetic process; pentose-phosphate shunt, oxidative branch; phosphogluconate dehydrogenase (decarboxylating) activity" IPR008927; IPR006114; IPR006113; IPR006115; IPR006184; IPR013328; IPR012284; IPR016040; Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. "6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)" PGD PGDH Homo sapiens (Human) TR42345_c2_g2_i1 Q8LF21 DRP1C_ARATH 1.00E-72 GO:0005525; GO:0006184; GO:0003924; GO:0005938; GO:0007049; GO:0051301; GO:0009504; GO:0005874; GO:0000266; GO:0009524; GO:0005886; GO:0009506; GO:0010152 GTP binding; GTP catabolic process; GTPase activity; cell cortex; cell cycle; cell division; cell plate; microtubule; mitochondrial fission; phragmoplast; plasma membrane; plasmodesma; pollen maturation IPR000375; IPR001401; IPR019762; IPR022812; IPR003130; IPR020850; IPR027417; Dynamin-related protein 1C (Dynamin-like protein 5) (Dynamin-like protein C) (Dynamin-like protein DLP1) DRP1C ADL1C ADL5 DLP1 At1g14830 F10B6.23 Arabidopsis thaliana (Mouse-ear cress) TR42345_c2_g3_i1 A6H7I5 DYN2_BOVIN 0 GO:0005525; GO:0006184; GO:0003924; GO:0030054; GO:0005737; GO:0006897; GO:0005874; GO:0030496; GO:0005543; GO:0014069; GO:0045211 GTP binding; GTP catabolic process; GTPase activity; cell junction; cytoplasm; endocytosis; microtubule; midbody; phospholipid binding; postsynaptic density; postsynaptic membrane IPR027188; IPR000375; IPR001401; IPR019762; IPR022812; IPR003130; IPR020850; IPR027417; IPR011993; IPR001849; Dynamin-2 (EC 3.6.5.5) DNM2 Bos taurus (Bovine) TR42345_c2_g3_i5 Q08DF4 DYN1_BOVIN 0 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0007032; GO:0005874; GO:0005543; GO:0006898 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; endosome organization; microtubule; phospholipid binding; receptor-mediated endocytosis IPR027741; IPR000375; IPR001401; IPR019762; IPR022812; IPR003130; IPR020850; IPR027417; IPR011993; IPR001849; Dynamin-1 (EC 3.6.5.5) DNM1 Bos taurus (Bovine) TR42347_c0_g2_i6 Q9U5L1 SRPR_DROME 1.00E-170 GO:0005525; GO:0003924; GO:0003723; GO:0006614; GO:0007409; GO:0005789; GO:0005811; GO:0050708; GO:0005047; GO:0005785 GTP binding; GTPase activity; RNA binding; SRP-dependent cotranslational protein targeting to membrane; axonogenesis; endoplasmic reticulum membrane; lipid particle; regulation of protein secretion; signal recognition particle binding; signal recognition particle receptor complex IPR003593; IPR011012; IPR027417; IPR007222; IPR013822; IPR000897; Signal recognition particle receptor subunit alpha homolog (DP-alpha) (Docking protein alpha) (SR-alpha) (GTP-binding protein) Gtp-bp CG2522 Drosophila melanogaster (Fruit fly) TR42348_c0_g2_i1 P31649 S6A13_MOUSE 2.00E-134 GO:0005332; GO:0005887; GO:0005328 gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR002981; Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Sodium- and chloride-dependent GABA transporter 3) (GAT-3) (Solute carrier family 6 member 13) Slc6a13 Gabt2 Gabt3 Gat-3 Gat2 Gat3 Mus musculus (Mouse) TR42348_c0_g2_i10 P31649 S6A13_MOUSE 2.00E-134 GO:0005332; GO:0005887; GO:0005328 gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR002981; Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Sodium- and chloride-dependent GABA transporter 3) (GAT-3) (Solute carrier family 6 member 13) Slc6a13 Gabt2 Gabt3 Gat-3 Gat2 Gat3 Mus musculus (Mouse) TR42348_c0_g2_i12 Q62687 S6A18_RAT 7.00E-40 GO:0006865; GO:0006972; GO:0005887; GO:0005328 amino acid transport; hyperosmotic response; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR002438; Sodium-dependent neutral amino acid transporter B(0)AT3 (Renal osmotic stress-induced Na-Cl organic solute cotransporter) (ROSIT) (Sodium- and chloride-dependent transporter XTRP2) (Solute carrier family 6 member 18) (System B(0) neutral amino acid transporter AT3) Slc6a18 Xtrp2 Rattus norvegicus (Rat) TR42348_c0_g2_i13 P31650 S6A11_MOUSE 3.00E-108 GO:0007420; GO:0042995; GO:0005737; GO:0005332; GO:0005887; GO:0042165; GO:0005328; GO:0042493 brain development; cell projection; cytoplasm; gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; neurotransmitter binding; neurotransmitter:sodium symporter activity; response to drug IPR000175; IPR002982; Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Sodium- and chloride-dependent GABA transporter 4) (GAT-4) (Solute carrier family 6 member 11) Slc6a11 Gabt3 Gabt4 Gat-4 Gat3 Gat4 Mus musculus (Mouse) TR42348_c0_g2_i3 P31650 S6A11_MOUSE 4.00E-108 GO:0007420; GO:0042995; GO:0005737; GO:0005332; GO:0005887; GO:0042165; GO:0005328; GO:0042493 brain development; cell projection; cytoplasm; gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; neurotransmitter binding; neurotransmitter:sodium symporter activity; response to drug IPR000175; IPR002982; Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Sodium- and chloride-dependent GABA transporter 4) (GAT-4) (Solute carrier family 6 member 11) Slc6a11 Gabt3 Gabt4 Gat-4 Gat3 Gat4 Mus musculus (Mouse) TR42348_c0_g2_i5 O34383 YOCR_BACSU 1.00E-07 GO:0016021; GO:0005328; GO:0005886 integral to membrane; neurotransmitter:sodium symporter activity; plasma membrane IPR000175; Uncharacterized sodium-dependent transporter YocR yocR BSU19340 Bacillus subtilis (strain 168) TR42348_c0_g2_i6 Q9MZ34 SC6A6_BOVIN 3.00E-107 GO:0005887; GO:0005328; GO:0005369 integral to plasma membrane; neurotransmitter:sodium symporter activity; taurine:sodium symporter activity IPR000175; IPR002434; Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6) SLC6A6 Bos taurus (Bovine) TR42348_c0_g2_i8 P31650 S6A11_MOUSE 4.00E-108 GO:0007420; GO:0042995; GO:0005737; GO:0005332; GO:0005887; GO:0042165; GO:0005328; GO:0042493 brain development; cell projection; cytoplasm; gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; neurotransmitter binding; neurotransmitter:sodium symporter activity; response to drug IPR000175; IPR002982; Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Sodium- and chloride-dependent GABA transporter 4) (GAT-4) (Solute carrier family 6 member 11) Slc6a11 Gabt3 Gabt4 Gat-4 Gat3 Gat4 Mus musculus (Mouse) TR42349_c0_g4_i1 Q3SX42 CHM2B_BOVIN 3.00E-48 GO:0005829; GO:0031902; GO:0005739; GO:0005634; GO:0015031 cytosol; late endosome membrane; mitochondrion; nucleus; protein transport IPR005024; Charged multivesicular body protein 2b (Chromatin-modifying protein 2b) (CHMP2b) CHMP2B Bos taurus (Bovine) TR42349_c0_g4_i4 Q3SX42 CHM2B_BOVIN 2.00E-49 GO:0005829; GO:0031902; GO:0005739; GO:0005634; GO:0015031 cytosol; late endosome membrane; mitochondrion; nucleus; protein transport IPR005024; Charged multivesicular body protein 2b (Chromatin-modifying protein 2b) (CHMP2b) CHMP2B Bos taurus (Bovine) TR42351_c0_g1_i1 Q5VW36 FOCAD_HUMAN 8.00E-30 GO:0005925; GO:0016021 focal adhesion; integral to membrane IPR016024; IPR021392; IPR022542; Focadhesin FOCAD KIAA1797 Homo sapiens (Human) TR42351_c1_g4_i1 Q5VW36 FOCAD_HUMAN 1.00E-154 GO:0005925; GO:0016021 focal adhesion; integral to membrane IPR016024; IPR021392; IPR022542; Focadhesin FOCAD KIAA1797 Homo sapiens (Human) TR42352_c0_g1_i2 Q0VBY0 MTCNB_BOVIN 8.00E-10 GO:0005739 mitochondrion IPR009069; IPR027179; Cx9C motif-containing protein 4 (Mature T-cell proliferation 1 neighbor protein) CMC4 MTCP1NB Bos taurus (Bovine) TR42352_c1_g1_i1 Q148D5 SUCB1_BOVIN 0 GO:0005524; GO:0046872; GO:0005739; GO:0004775; GO:0006099 ATP binding; metal ion binding; mitochondrion; succinate-CoA ligase (ADP-forming) activity; tricarboxylic acid cycle IPR011761; IPR013650; IPR013815; IPR013816; IPR005811; IPR017866; IPR005809; IPR016102; Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. "Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)" SUCLA2 Bos taurus (Bovine) TR42352_c1_g1_i3 P53312 SUCB_YEAST 4.00E-121 GO:0005524; GO:0005739; GO:0004775; GO:0006104; GO:0006099 ATP binding; mitochondrion; succinate-CoA ligase (ADP-forming) activity; succinyl-CoA metabolic process; tricarboxylic acid cycle IPR013650; IPR013815; IPR013816; IPR005811; IPR017866; IPR005809; IPR016102; Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. "Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (Succinyl-CoA synthetase beta chain) (SCS-beta)" LSC2 YGR244C G8625 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42352_c1_g1_i5 P86226 SUCB1_MESAU 2.00E-73 GO:0005524; GO:0005739; GO:0004775; GO:0006099 ATP binding; mitochondrion; succinate-CoA ligase (ADP-forming) activity; tricarboxylic acid cycle IPR013650; IPR013816; IPR005809; IPR016102; Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. "Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA) (Fragments)" SUCLA2 Mesocricetus auratus (Golden hamster) TR42352_c1_g1_i6 Q148D5 SUCB1_BOVIN 0 GO:0005524; GO:0046872; GO:0005739; GO:0004775; GO:0006099 ATP binding; metal ion binding; mitochondrion; succinate-CoA ligase (ADP-forming) activity; tricarboxylic acid cycle IPR011761; IPR013650; IPR013815; IPR013816; IPR005811; IPR017866; IPR005809; IPR016102; Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. "Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)" SUCLA2 Bos taurus (Bovine) TR42353_c0_g4_i1 Q96Q42 ALS2_HUMAN 0 GO:0017137; GO:0017112; GO:0030676; GO:0016601; GO:0005087; GO:0030424; GO:0007409; GO:0001662; GO:0008219; GO:0005813; GO:0005829; GO:0030425; GO:0043197; GO:0005769; GO:0016197; GO:0007032; GO:0030426; GO:0001701; GO:0030027; GO:0007626; GO:0016020; GO:0007528; GO:0048812; GO:0043025; GO:0005543; GO:0032855; GO:0035022; GO:0014069; GO:0043234; GO:0008104; GO:0043539; GO:0001881; GO:0032313; GO:0051036; GO:0006979; GO:0001726; GO:0035249; GO:0031982; GO:0016050 P20339 "Rab GTPase binding; Rab guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; Rac protein signal transduction; Ran guanyl-nucleotide exchange factor activity; axon; axonogenesis; behavioral fear response; cell death; centrosome; cytosol; dendrite; dendritic spine; early endosome; endosomal transport; endosome organization; growth cone; in utero embryonic development; lamellipodium; locomotory behavior; membrane; neuromuscular junction development; neuron projection morphogenesis; neuronal cell body; phospholipid binding; positive regulation of Rac GTPase activity; positive regulation of Rac protein signal transduction; postsynaptic density; protein complex; protein localization; protein serine/threonine kinase activator activity; receptor recycling; regulation of Rab GTPase activity; regulation of endosome size; response to oxidative stress; ruffle; synaptic transmission, glutamatergic; vesicle; vesicle organization" IPR000219; IPR003409; IPR011993; IPR001849; IPR009091; IPR000408; IPR003123; Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) ALS2 ALS2CR6 KIAA1563 Homo sapiens (Human) TR42353_c0_g4_i2 Q96Q42 ALS2_HUMAN 0 GO:0017137; GO:0017112; GO:0030676; GO:0016601; GO:0005087; GO:0030424; GO:0007409; GO:0001662; GO:0008219; GO:0005813; GO:0005829; GO:0030425; GO:0043197; GO:0005769; GO:0016197; GO:0007032; GO:0030426; GO:0001701; GO:0030027; GO:0007626; GO:0016020; GO:0007528; GO:0048812; GO:0043025; GO:0005543; GO:0032855; GO:0035022; GO:0014069; GO:0043234; GO:0008104; GO:0043539; GO:0001881; GO:0032313; GO:0051036; GO:0006979; GO:0001726; GO:0035249; GO:0031982; GO:0016050 P20339 "Rab GTPase binding; Rab guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; Rac protein signal transduction; Ran guanyl-nucleotide exchange factor activity; axon; axonogenesis; behavioral fear response; cell death; centrosome; cytosol; dendrite; dendritic spine; early endosome; endosomal transport; endosome organization; growth cone; in utero embryonic development; lamellipodium; locomotory behavior; membrane; neuromuscular junction development; neuron projection morphogenesis; neuronal cell body; phospholipid binding; positive regulation of Rac GTPase activity; positive regulation of Rac protein signal transduction; postsynaptic density; protein complex; protein localization; protein serine/threonine kinase activator activity; receptor recycling; regulation of Rab GTPase activity; regulation of endosome size; response to oxidative stress; ruffle; synaptic transmission, glutamatergic; vesicle; vesicle organization" IPR000219; IPR003409; IPR011993; IPR001849; IPR009091; IPR000408; IPR003123; Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) ALS2 ALS2CR6 KIAA1563 Homo sapiens (Human) TR42355_c2_g5_i14 P18758 TYB4_XENLA 7.00E-07 GO:0030036; GO:0005737; GO:0005856; GO:0042989 actin cytoskeleton organization; cytoplasm; cytoskeleton; sequestering of actin monomers IPR001152; IPR016323; Thymosin beta-4 (T beta 4) (Thymosin beta 4Xen) tmsb4 Xenopus laevis (African clawed frog) TR42356_c0_g4_i1 P50616 TOB1_HUMAN 1.00E-51 GO:0005070; GO:0007184; GO:0005737; GO:0030514; GO:0008285; GO:0060212; GO:0045668; GO:0017148; GO:0030971; GO:0003714 A5YKK6; O75175; Q96LI5; Q9UIV1; Q8NE35; Q17RY0 SH3/SH2 adaptor activity; SMAD protein import into nucleus; cytoplasm; negative regulation of BMP signaling pathway; negative regulation of cell proliferation; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; negative regulation of osteoblast differentiation; negative regulation of translation; receptor tyrosine kinase binding; transcription corepressor activity IPR002087; IPR015676; Protein Tob1 (Transducer of erbB-2 1) TOB1 TOB TROB1 Homo sapiens (Human) TR42356_c0_g4_i2 Q8R5K6 TOB1_RAT 4.00E-51 GO:0008285; GO:0060212; GO:0017148; GO:0030971 negative regulation of cell proliferation; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; negative regulation of translation; receptor tyrosine kinase binding IPR002087; IPR015676; Protein Tob1 (Transducer of erbB-2 1) Tob1 Rattus norvegicus (Rat) TR42357_c0_g1_i5 Q8VD57 SFT2B_MOUSE 2.00E-53 GO:0016021; GO:0015031; GO:0016192 integral to membrane; protein transport; vesicle-mediated transport IPR007305; IPR011691; Vesicle transport protein SFT2B (SFT2 domain-containing protein 2) Sft2d2 Mus musculus (Mouse) TR42361_c0_g1_i1 P07742 RIR1_MOUSE 0 GO:0005524; GO:0006260; GO:0009263; GO:0051290; GO:0017076; GO:0004748; GO:0005971 "ATP binding; DNA replication; deoxyribonucleotide biosynthetic process; protein heterotetramerization; purine nucleotide binding; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; ribonucleoside-diphosphate reductase complex" IPR005144; IPR013346; IPR000788; IPR013509; IPR008926; Genetic information processing; DNA replication. Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit) Rrm1 Mus musculus (Mouse) TR42361_c0_g1_i5 P07742 RIR1_MOUSE 0 GO:0005524; GO:0006260; GO:0009263; GO:0051290; GO:0017076; GO:0004748; GO:0005971 "ATP binding; DNA replication; deoxyribonucleotide biosynthetic process; protein heterotetramerization; purine nucleotide binding; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; ribonucleoside-diphosphate reductase complex" IPR005144; IPR013346; IPR000788; IPR013509; IPR008926; Genetic information processing; DNA replication. Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit) Rrm1 Mus musculus (Mouse) TR42361_c0_g1_i6 Q6GZT8 RIR1_FRG3G 3.00E-33 GO:0006260; GO:0004748 "DNA replication; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor" IPR000788; Genetic information processing; DNA replication. Putative ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleotide reductase large subunit) FV3-038R Frog virus 3 (isolate Goorha) (FV-3) TR42361_c0_g2_i2 P55982 RIR1_HELPY 1.00E-42 GO:0005524; GO:0006260; GO:0004748; GO:0005971 "ATP binding; DNA replication; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; ribonucleoside-diphosphate reductase complex" IPR005144; IPR013346; IPR000788; IPR013509; IPR008926; Genetic information processing; DNA replication. Ribonucleoside-diphosphate reductase subunit alpha (EC 1.17.4.1) (Ribonucleotide reductase) nrdA HP_0680 Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) TR42361_c0_g2_i3 O66503 RIR1_AQUAE 2.00E-48 GO:0005524; GO:0006260; GO:0004748; GO:0005971 "ATP binding; DNA replication; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; ribonucleoside-diphosphate reductase complex" IPR005144; IPR013346; IPR000788; IPR013509; IPR008926; Genetic information processing; DNA replication. Ribonucleoside-diphosphate reductase subunit alpha (EC 1.17.4.1) (Ribonucleotide reductase) nrdA aq_094 Aquifex aeolicus (strain VF5) TR42362_c0_g1_i1 O55226 CHAD_MOUSE 7.00E-16 GO:0001502; GO:0005578 cartilage condensation; proteinaceous extracellular matrix IPR000483; IPR001611; IPR003591; IPR000372; Chondroadherin (Cartilage leucine-rich protein) Chad Mus musculus (Mouse) TR42362_c0_g1_i2 O02833 ALS_PAPHA 9.00E-31 GO:0007155; GO:0005615 cell adhesion; extracellular space IPR000483; IPR001611; IPR003591; IPR000372; Insulin-like growth factor-binding protein complex acid labile subunit (ALS) IGFALS ALS Papio hamadryas (Hamadryas baboon) TR42362_c0_g1_i3 P08953 TOLL_DROME 1.00E-31 GO:0033565; GO:0008063; GO:0019732; GO:0007155; GO:0019955; GO:0050830; GO:0005769; GO:0009897; GO:0007507; GO:0035172; GO:0030097; GO:0045087; GO:0016021; GO:0006963; GO:0006967; GO:0045610; GO:0007416; GO:0016201; GO:0004888; GO:0007352 Itself; Q7K105 ESCRT-0 complex; Toll signaling pathway; antifungal humoral response; cell adhesion; cytokine binding; defense response to Gram-positive bacterium; early endosome; external side of plasma membrane; heart development; hemocyte proliferation; hemopoiesis; innate immune response; integral to membrane; positive regulation of antibacterial peptide biosynthetic process; positive regulation of antifungal peptide biosynthetic process; regulation of hemocyte differentiation; synapse assembly; synaptic target inhibition; transmembrane signaling receptor activity; zygotic specification of dorsal/ventral axis IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) TR42362_c0_g1_i4 P22792 CPN2_HUMAN 1.00E-16 GO:0030234; GO:0005576; GO:0050821 enzyme regulator activity; extracellular region; protein stabilization IPR000483; IPR001611; IPR025875; IPR003591; IPR000372; Carboxypeptidase N subunit 2 (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N large subunit) (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N regulatory subunit) CPN2 ACBP Homo sapiens (Human) TR42364_c0_g1_i1 P04836 CBPE_BOVIN 2.00E-57 GO:0005794; GO:0003214; GO:0005576; GO:0030070; GO:0004181; GO:0072657; GO:0006508; GO:0030658; GO:0008270 Golgi apparatus; cardiac left ventricle morphogenesis; extracellular region; insulin processing; metallocarboxypeptidase activity; protein localization to membrane; proteolysis; transport vesicle membrane; zinc ion binding IPR008969; IPR014766; IPR000834; Carboxypeptidase E (CPE) (EC 3.4.17.10) (Carboxypeptidase H) (CPH) (Enkephalin convertase) (Prohormone-processing carboxypeptidase) CPE Bos taurus (Bovine) TR42364_c0_g2_i1 P37892 CBPE_LOPAM 6.00E-55 GO:0005576; GO:0004181; GO:0006508; GO:0030658; GO:0008270 extracellular region; metallocarboxypeptidase activity; proteolysis; transport vesicle membrane; zinc ion binding IPR008969; IPR014766; IPR000834; Carboxypeptidase E (CPE) (EC 3.4.17.10) (Carboxypeptidase H) (CPH) (Enkephalin convertase) (Prohormone-processing carboxypeptidase) cpe Lophius americanus (American goosefish) (Anglerfish) TR42365_c1_g1_i10 Q6PGW3 CJ076_DANRE 0 GO:0016021 integral to membrane IPR016024; IPR013636; UPF0668 protein C10orf76 homolog zgc:63733 Danio rerio (Zebrafish) (Brachydanio rerio) TR42365_c1_g1_i3 Q6PGW3 CJ076_DANRE 0 GO:0016021 integral to membrane IPR016024; IPR013636; UPF0668 protein C10orf76 homolog zgc:63733 Danio rerio (Zebrafish) (Brachydanio rerio) TR42366_c0_g1_i2 Q5M7M7 STAU2_XENTR 8.00E-13 GO:0003723; GO:0005874; GO:0006810 RNA binding; microtubule; transport IPR014720; Double-stranded RNA-binding protein Staufen homolog 2 stau2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42366_c0_g1_i3 B6P4U0 TRBP2_BRAFL 1.00E-58 TR42367_c1_g1_i1 P22897 MRC1_HUMAN 4.00E-106 GO:0010008; GO:0005887; GO:0005537; GO:0004872; GO:0006898 endosome membrane; integral to plasma membrane; mannose binding; receptor activity; receptor-mediated endocytosis IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206) MRC1 CLEC13D CLEC13DL MRC1L1 Homo sapiens (Human) TR42367_c1_g1_i3 P22897 MRC1_HUMAN 4.00E-106 GO:0010008; GO:0005887; GO:0005537; GO:0004872; GO:0006898 endosome membrane; integral to plasma membrane; mannose binding; receptor activity; receptor-mediated endocytosis IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206) MRC1 CLEC13D CLEC13DL MRC1L1 Homo sapiens (Human) TR42367_c1_g1_i4 P00747 PLMN_HUMAN 2.00E-17 GO:0006915; GO:0044267; GO:0022617; GO:0005615; GO:0031232; GO:0042730; GO:0060716; GO:0071674; GO:0046716; GO:0045445; GO:0008285; GO:2000048; GO:0010812; GO:0051918; GO:0030168; GO:0031093; GO:0002576; GO:0051919; GO:0051603; GO:0004252; GO:0042246; GO:0048771; GO:0060707 Q6V4L1; Q6V4L4; Q6V4L5; Q6V4L9; Q99SU7; P00779 apoptotic process; cellular protein metabolic process; extracellular matrix disassembly; extracellular space; extrinsic to external side of plasma membrane; fibrinolysis; labyrinthine layer blood vessel development; mononuclear cell migration; muscle cell cellular homeostasis; myoblast differentiation; negative regulation of cell proliferation; negative regulation of cell-cell adhesion mediated by cadherin; negative regulation of cell-substrate adhesion; negative regulation of fibrinolysis; platelet activation; platelet alpha granule lumen; platelet degranulation; positive regulation of fibrinolysis; proteolysis involved in cellular protein catabolic process; serine-type endopeptidase activity; tissue regeneration; tissue remodeling; trophoblast giant cell differentiation IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Homo sapiens (Human) TR42369_c0_g1_i13 Q5E953 UFC1_BOVIN 6.00E-102 GO:0071568; GO:0071569 UFM1 conjugating enzyme activity; protein ufmylation IPR016135; IPR014806; Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1) UFC1 Bos taurus (Bovine) TR42369_c0_g1_i6 Q5E953 UFC1_BOVIN 3.00E-99 GO:0071568; GO:0071569 UFM1 conjugating enzyme activity; protein ufmylation IPR016135; IPR014806; Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1) UFC1 Bos taurus (Bovine) TR42369_c0_g1_i7 B4J9W6 UFC1_DROGR 9.00E-93 IPR016135; IPR014806; Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1) GH19828 Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) TR42370_c0_g1_i1 Q96RW7 HMCN1_HUMAN 4.00E-11 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR42370_c0_g1_i2 Q61982 NOTC3_MOUSE 4.00E-16 GO:0007219; GO:0005509; GO:0030900; GO:0072104; GO:0005887; GO:0045665; GO:0048663; GO:0005634; GO:0048661; GO:0006355; GO:0006351 "Notch signaling pathway; calcium ion binding; forebrain development; glomerular capillary formation; integral to plasma membrane; negative regulation of neuron differentiation; neuron fate commitment; nucleus; positive regulation of smooth muscle cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022331; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] Notch3 Mus musculus (Mouse) TR42370_c0_g1_i3 P07207 NOTCH_DROME 7.00E-17 GO:0005796; GO:0061382; GO:0007219; GO:0048052; GO:0007464; GO:0045466; GO:0045463; GO:0007460; GO:0007015; GO:0005912; GO:0008356; GO:0007298; GO:0005509; GO:0009986; GO:0008407; GO:0003682; GO:0042676; GO:0046667; GO:0005829; GO:0008340; GO:0046843; GO:0007391; GO:0007451; GO:0007398; GO:0035165; GO:0005788; GO:0005768; GO:0061331; GO:0035153; GO:0035214; GO:0007440; GO:0060288; GO:0030718; GO:0030708; GO:0007403; GO:0008347; GO:0035172; GO:0007157; GO:0007446; GO:0016348; GO:0048803; GO:0008587; GO:0007474; GO:0016021; GO:0035171; GO:0046331; GO:0007616; GO:0035170; GO:0007498; GO:0008045; GO:0007521; GO:0046329; GO:0045316; GO:0035157; GO:0050768; GO:0035155; GO:0000122; GO:0007400; GO:0005654; GO:0007314; GO:0030720; GO:0030713; GO:0007422; GO:1900087; GO:0045747; GO:0008284; GO:0045944; GO:0043234; GO:0045468; GO:0042686; GO:0042689; GO:0051489; GO:0040008; GO:0009608; GO:0016330; GO:0007519; GO:0035003; GO:0006351; GO:0004888; GO:0007419; GO:0048190; GO:0007473 Q24279; P10041; P28159 "Golgi lumen; Malpighian tubule tip cell differentiation; Notch signaling pathway; R1/R6 cell differentiation; R3/R4 cell fate commitment; R7 cell differentiation; R8 cell development; R8 cell fate commitment; actin filament organization; adherens junction; asymmetric cell division; border follicle cell migration; calcium ion binding; cell surface; chaeta morphogenesis; chromatin binding; compound eye cone cell fate commitment; compound eye retinal cell programmed cell death; cytosol; determination of adult lifespan; dorsal appendage formation; dorsal closure; dorsal/ventral lineage restriction, imaginal disc; ectoderm development; embryonic crystal cell differentiation; endoplasmic reticulum lumen; endosome; epithelial cell proliferation involved in Malpighian tubule morphogenesis; epithelial cell type specification, open tracheal system; eye-antennal disc development; foregut morphogenesis; formation of a compartment boundary; germ-line stem cell maintenance; germarium-derived female germ-line cyst encapsulation; glial cell fate determination; glial cell migration; hemocyte proliferation; heterophilic cell-cell adhesion; imaginal disc growth; imaginal disc-derived leg joint morphogenesis; imaginal disc-derived male genitalia morphogenesis; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein specification; integral to membrane; lamellocyte differentiation; lateral inhibition; long-term memory; lymph gland crystal cell differentiation; mesoderm development; motor neuron axon guidance; muscle cell fate determination; negative regulation of JNK cascade; negative regulation of compound eye photoreceptor development; negative regulation of fusion cell fate specification; negative regulation of neurogenesis; negative regulation of terminal cell fate specification, open tracheal system; negative regulation of transcription from RNA polymerase II promoter; neuroblast fate determination; nucleoplasm; oocyte anterior/posterior axis specification; oocyte localization involved in germarium-derived egg chamber formation; ovarian follicle cell stalk formation; peripheral nervous system development; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of Notch signaling pathway; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; protein complex; regulation of R8 cell spacing in compound eye; regulation of cardioblast cell fate specification; regulation of crystal cell differentiation; regulation of filopodium assembly; regulation of growth; response to symbiont; second mitotic wave involved in compound eye morphogenesis; skeletal muscle tissue development; subapical complex; transcription, DNA-dependent; transmembrane signaling receptor activity; ventral cord development; wing disc dorsal/ventral pattern formation; wing disc proximal/distal pattern formation" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR000800; IPR010660; IPR011656; Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) TR42370_c1_g1_i1 Q5IS41 NCAN_PANTR 5.00E-20 GO:0005509; GO:0030246; GO:0007155; GO:0005576; GO:0005540 calcium ion binding; carbohydrate binding; cell adhesion; extracellular region; hyaluronic acid binding IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Neurocan core protein (Chondroitin sulfate proteoglycan 3) NCAN CSPG3 Pan troglodytes (Chimpanzee) TR42374_c1_g1_i4 Q54NV1 EXOC1_DICDI 6.00E-20 GO:0006887; GO:0015031 exocytosis; protein transport IPR019160; Exocyst complex component 1 (Exocyst complex component Sec3) exoc1 sec3 DDB_G0285067 Dictyostelium discoideum (Slime mold) TR42374_c1_g2_i1 Q9NV70 EXOC1_HUMAN 3.00E-163 GO:0044267; GO:0000145; GO:0006887; GO:0005886; GO:0015031 cellular protein metabolic process; exocyst; exocytosis; plasma membrane; protein transport IPR019160; IPR028258; Exocyst complex component 1 (Exocyst complex component Sec3) EXOC1 SEC3 SEC3L1 BM-012 Homo sapiens (Human) TR42374_c1_g2_i2 Q9VVG4 EXOC1_DROME 4.00E-116 GO:0006887; GO:0015031 exocytosis; protein transport IPR019160; IPR028258; Exocyst complex component 1 (Exocyst complex component Sec3) sec3 CG3885 Drosophila melanogaster (Fruit fly) TR42374_c1_g2_i3 Q8R3T5 STXB6_MOUSE 5.00E-17 GO:0005737; GO:0016021; GO:0016192 cytoplasm; integral to membrane; vesicle-mediated transport IPR028258; IPR001388; Syntaxin-binding protein 6 Stxbp6 Mus musculus (Mouse) TR42374_c1_g2_i5 Q9NV70 EXOC1_HUMAN 1.00E-46 GO:0044267; GO:0000145; GO:0006887; GO:0005886; GO:0015031 cellular protein metabolic process; exocyst; exocytosis; plasma membrane; protein transport IPR019160; IPR028258; Exocyst complex component 1 (Exocyst complex component Sec3) EXOC1 SEC3 SEC3L1 BM-012 Homo sapiens (Human) TR42375_c0_g2_i1 Q28DG8 THOC5_XENTR 7.00E-121 GO:0003723; GO:0008380; GO:0030154; GO:0005737; GO:0006397; GO:0051028; GO:0005634 RNA binding; RNA splicing; cell differentiation; cytoplasm; mRNA processing; mRNA transport; nucleus IPR019163; THO complex subunit 5 homolog thoc5 TEgg015p03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42378_c2_g5_i1 P41950 YLK2_CAEEL 6.00E-07 GO:0003391; GO:0005509; GO:0007160; GO:0032590; GO:0016021 amphid sensory organ dendrite retrograde extension; calcium ion binding; cell-matrix adhesion; dendrite membrane; integral to membrane IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR023413; IPR009030; IPR003886; EGF-like domain-containing protein D1044.2 D1044.2 Caenorhabditis elegans TR42379_c5_g2_i1 Q5SS80 DHR13_MOUSE 1.00E-50 GO:0005576; GO:0016491 extracellular region; oxidoreductase activity IPR002198; IPR002347; IPR016040; Dehydrogenase/reductase SDR family member 13 (EC 1.1.-.-) Dhrs13 Mus musculus (Mouse) TR42379_c5_g2_i3 Q8BYK4 RDH12_MOUSE 1.00E-53 GO:0005622; GO:0050896; GO:0004745; GO:0042572; GO:0007601 intracellular; response to stimulus; retinol dehydrogenase activity; retinol metabolic process; visual perception IPR002198; IPR002347; IPR016040; Retinol dehydrogenase 12 (EC 1.1.1.-) Rdh12 Mus musculus (Mouse) TR42379_c6_g1_i2 Q6TLE6 CRCM1_DANRE 8.00E-45 GO:0005887; GO:0051928; GO:0045214; GO:0015279 integral to plasma membrane; positive regulation of calcium ion transport; sarcomere organization; store-operated calcium channel activity IPR012446; Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A) orai1 tmem142a zgc:109721 Danio rerio (Zebrafish) (Brachydanio rerio) TR42379_c6_g1_i3 Q5EAU0 CRCM1_XENLA 9.00E-52 GO:0005887; GO:0051928; GO:0015279 integral to plasma membrane; positive regulation of calcium ion transport; store-operated calcium channel activity IPR012446; Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A) orai1 tmem142a Xenopus laevis (African clawed frog) TR42380_c0_g1_i1 Q6WKZ8 UBR2_MOUSE 1.00E-22 GO:0071233; GO:0006342; GO:0033522; GO:0070728; GO:0007141; GO:0032007; GO:0005634; GO:0005886; GO:0007283; GO:0000151; GO:0006511; GO:0004842; GO:0008270 cellular response to leucine; chromatin silencing; histone H2A ubiquitination; leucine binding; male meiosis I; negative regulation of TOR signaling cascade; nucleus; plasma membrane; spermatogenesis; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR003769; IPR014719; IPR003126; IPR013993; IPR001841; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UBR2 (EC 6.3.2.-) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II) Ubr2 Kiaa0349 Mus musculus (Mouse) TR42380_c0_g3_i1 Q8IWV8 UBR2_HUMAN 0 GO:0071233; GO:0000785; GO:0006342; GO:0033522; GO:0070728; GO:0007141; GO:0032007; GO:0005634; GO:0005886; GO:0007283; GO:0000151; GO:0006511; GO:0004842; GO:0008270 P12504 cellular response to leucine; chromatin; chromatin silencing; histone H2A ubiquitination; leucine binding; male meiosis I; negative regulation of TOR signaling cascade; nucleus; plasma membrane; spermatogenesis; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR003769; IPR014719; IPR003126; IPR013993; IPR001841; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UBR2 (EC 6.3.2.-) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II) UBR2 C6orf133 KIAA0349 Homo sapiens (Human) TR42380_c0_g3_i2 O60014 UBR1_KLULA 3.00E-18 GO:0030163; GO:0004842; GO:0008270 protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR003769; IPR003126; IPR013993; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UBR1 (EC 6.3.2.-) (N-end-recognizing protein) (N-recognin-1) UBR1 KLLA0F15334g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR42380_c0_g3_i3 Q07963 UBR2_YEAST 1.00E-16 GO:0005737; GO:0006513; GO:0004842; GO:0008270 P06104 cytoplasm; protein monoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003126; IPR013993; IPR001841; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UBR2 (EC 6.3.2.-) (Ubiquitin-protein ligase E3 component N-recognin-1 homolog) UBR2 YLR024C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42380_c0_g3_i4 O70481 UBR1_MOUSE 0 GO:0071233; GO:0005829; GO:0070728; GO:0032007; GO:0000502; GO:0000151; GO:0006511; GO:0004842; GO:0008270 cellular response to leucine; cytosol; leucine binding; negative regulation of TOR signaling cascade; proteasome complex; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR003769; IPR014719; IPR003126; IPR013993; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UBR1 (EC 6.3.2.-) (N-recognin-1) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3-alpha-I) Ubr1 Mus musculus (Mouse) TR42380_c0_g3_i5 Q5U430 UBR3_MOUSE 5.00E-23 GO:0001701; GO:0016021; GO:0042048; GO:0007608; GO:0001967; GO:0006511; GO:0004842; GO:0008270 in utero embryonic development; integral to membrane; olfactory behavior; sensory perception of smell; suckling behavior; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR003126; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UBR3 (EC 6.3.2.-) (N-recognin-3) (Ubiquitin-protein ligase E3-alpha-3) (Ubiquitin-protein ligase E3-alpha-III) (Zinc finger protein 650) Ubr3 Kiaa2024 Zfp650 Znf650 Mus musculus (Mouse) TR42380_c0_g3_i6 Q6WKZ8 UBR2_MOUSE 0 GO:0071233; GO:0006342; GO:0033522; GO:0070728; GO:0007141; GO:0032007; GO:0005634; GO:0005886; GO:0007283; GO:0000151; GO:0006511; GO:0004842; GO:0008270 cellular response to leucine; chromatin silencing; histone H2A ubiquitination; leucine binding; male meiosis I; negative regulation of TOR signaling cascade; nucleus; plasma membrane; spermatogenesis; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR003769; IPR014719; IPR003126; IPR013993; IPR001841; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UBR2 (EC 6.3.2.-) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II) Ubr2 Kiaa0349 Mus musculus (Mouse) TR42380_c0_g3_i7 Q6WKZ8 UBR2_MOUSE 0 GO:0071233; GO:0006342; GO:0033522; GO:0070728; GO:0007141; GO:0032007; GO:0005634; GO:0005886; GO:0007283; GO:0000151; GO:0006511; GO:0004842; GO:0008270 cellular response to leucine; chromatin silencing; histone H2A ubiquitination; leucine binding; male meiosis I; negative regulation of TOR signaling cascade; nucleus; plasma membrane; spermatogenesis; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR003769; IPR014719; IPR003126; IPR013993; IPR001841; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UBR2 (EC 6.3.2.-) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II) Ubr2 Kiaa0349 Mus musculus (Mouse) TR42381_c0_g1_i5 Q15334 L2GL1_HUMAN 1.00E-67 GO:0000137; GO:0000139; GO:0006893; GO:0005097; GO:0030424; GO:0007409; GO:0030864; GO:0030866; GO:0031901; GO:0006887; GO:0035090; GO:0035748; GO:0006461; GO:0019901; GO:0005198; GO:0032588 Golgi cis cisterna; Golgi membrane; Golgi to plasma membrane transport; Rab GTPase activator activity; axon; axonogenesis; cortical actin cytoskeleton; cortical actin cytoskeleton organization; early endosome membrane; exocytosis; maintenance of apical/basal cell polarity; myelin sheath abaxonal region; protein complex assembly; protein kinase binding; structural molecule activity; trans-Golgi network membrane IPR000664; IPR013577; IPR015943; IPR001680; IPR019775; IPR017986; Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) LLGL1 DLG4 HUGL HUGL1 Homo sapiens (Human) TR42381_c0_g3_i1 Q80Y17 L2GL1_MOUSE 0 GO:0000137; GO:0000139; GO:0006893; GO:0005097; GO:0030424; GO:0007409; GO:0007420; GO:0030864; GO:0030866; GO:0005856; GO:0031901; GO:0006887; GO:0035090; GO:0035748; GO:0006461; GO:0032588 Golgi cis cisterna; Golgi membrane; Golgi to plasma membrane transport; Rab GTPase activator activity; axon; axonogenesis; brain development; cortical actin cytoskeleton; cortical actin cytoskeleton organization; cytoskeleton; early endosome membrane; exocytosis; maintenance of apical/basal cell polarity; myelin sheath abaxonal region; protein complex assembly; trans-Golgi network membrane IPR000664; IPR013905; IPR013577; IPR015943; IPR001680; IPR019775; IPR017986; Lethal(2) giant larvae protein homolog 1 (LLGL) (Mgl-1) (Mlgl) Llgl1 Llglh Mus musculus (Mouse) TR42382_c0_g1_i1 Q8R4U0 STAB2_MOUSE 1.00E-178 GO:0007155; GO:0005737; GO:0042742; GO:0006897; GO:0009897; GO:0005540; GO:0005887; GO:0030169; GO:0005041; GO:0005044 cell adhesion; cytoplasm; defense response to bacterium; endocytosis; external side of plasma membrane; hyaluronic acid binding; integral to plasma membrane; low-density lipoprotein particle binding; low-density lipoprotein receptor activity; scavenger receptor activity IPR016186; IPR016187; IPR000742; IPR013032; IPR024731; IPR000782; IPR023413; IPR000538; "Stabilin-2 (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2) (FEEL-2) [Cleaved into: Short form stabilin-2]" Stab2 Feel2 Hare Mus musculus (Mouse) TR42382_c0_g1_i2 Q20911 CUBN_CAEEL 1.00E-11 GO:0005509; GO:0005576; GO:0006629; GO:0015031 calcium ion binding; extracellular region; lipid metabolic process; protein transport IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; Probable cubilin ZC116.3 Caenorhabditis elegans TR42382_c0_g1_i4 Q8R4U0 STAB2_MOUSE 1.00E-178 GO:0007155; GO:0005737; GO:0042742; GO:0006897; GO:0009897; GO:0005540; GO:0005887; GO:0030169; GO:0005041; GO:0005044 cell adhesion; cytoplasm; defense response to bacterium; endocytosis; external side of plasma membrane; hyaluronic acid binding; integral to plasma membrane; low-density lipoprotein particle binding; low-density lipoprotein receptor activity; scavenger receptor activity IPR016186; IPR016187; IPR000742; IPR013032; IPR024731; IPR000782; IPR023413; IPR000538; "Stabilin-2 (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2) (FEEL-2) [Cleaved into: Short form stabilin-2]" Stab2 Feel2 Hare Mus musculus (Mouse) TR42382_c0_g2_i2 Q14517 FAT1_HUMAN 6.00E-11 GO:0007015; GO:0009653; GO:0005509; GO:0016477; GO:0016337; GO:0005911; GO:0007267; GO:0007163; GO:0030175; GO:0007156; GO:0005887; GO:0030027; GO:0005634; GO:0048471 Q8N8S7; Q9NSC5; Q99JP6 actin filament organization; anatomical structure morphogenesis; calcium ion binding; cell migration; cell-cell adhesion; cell-cell junction; cell-cell signaling; establishment or maintenance of cell polarity; filopodium; homophilic cell adhesion; integral to plasma membrane; lamellipodium; nucleus; perinuclear region of cytoplasm IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) TR42382_c0_g2_i3 Q06805 TIE1_BOVIN 2.00E-08 GO:0005524; GO:0001525; GO:0016021; GO:0018108; GO:0005886; GO:0004714 ATP binding; angiogenesis; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; transmembrane receptor protein tyrosine kinase activity IPR000742; IPR013032; IPR003961; IPR013783; IPR003599; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE TIE-1 Bos taurus (Bovine) TR42384_c2_g4_i1 O15973 OPSD1_MIZYE 1.00E-08 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR000856; IPR027430; "Rhodopsin, GQ-coupled (GQ-rhodopsin)" SCOP1 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) TR42384_c2_g4_i2 P70585 GPR19_RAT 6.00E-07 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR000276; IPR017452; Probable G-protein coupled receptor 19 Gpr19 Rattus norvegicus (Rat) TR42384_c2_g4_i3 O15973 OPSD1_MIZYE 4.00E-08 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR000856; IPR027430; "Rhodopsin, GQ-coupled (GQ-rhodopsin)" SCOP1 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) TR42385_c0_g1_i10 Q12059 ULA1_YEAST 9.00E-27 GO:0005524; GO:0019781; GO:0045116 Q99344 ATP binding; NEDD8 activating enzyme activity; protein neddylation IPR009036; IPR016040; Protein modification; protein neddylation. NEDD8-activating enzyme E1 regulatory subunit (E1 N-terminus-related protein 2) (Ubiquitin-activating enzyme E1-like 1) (Ubiquitin-like activation protein 1) ULA1 ENR2 YPL003W LPA14W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42385_c0_g1_i11 Q5ZIE6 ULA1_CHICK 0 GO:0003824; GO:0045116 catalytic activity; protein neddylation IPR009036; IPR016040; IPR000594; Protein modification; protein neddylation. NEDD8-activating enzyme E1 regulatory subunit (APP-BP1) (Amyloid protein-binding protein 1) NAE1 APPBP1 RCJMB04_27g6 Gallus gallus (Chicken) TR42385_c0_g1_i3 Q6NTW6 ULA1_XENLA 0 GO:0003824; GO:0045116 catalytic activity; protein neddylation IPR009036; IPR016040; IPR000594; Protein modification; protein neddylation. NEDD8-activating enzyme E1 regulatory subunit (APP-BP1) (Amyloid protein-binding protein 1) nae1 appbp1 Xenopus laevis (African clawed frog) TR42385_c0_g1_i5 Q12059 ULA1_YEAST 2.00E-27 GO:0005524; GO:0019781; GO:0045116 Q99344 ATP binding; NEDD8 activating enzyme activity; protein neddylation IPR009036; IPR016040; Protein modification; protein neddylation. NEDD8-activating enzyme E1 regulatory subunit (E1 N-terminus-related protein 2) (Ubiquitin-activating enzyme E1-like 1) (Ubiquitin-like activation protein 1) ULA1 ENR2 YPL003W LPA14W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42385_c0_g1_i6 Q28DS0 SAE1_XENTR 6.00E-22 GO:0016874; GO:0005634; GO:0008022; GO:0016925; GO:0008641 ligase activity; nucleus; protein C-terminus binding; protein sumoylation; small protein activating enzyme activity IPR009036; IPR016040; IPR000594; IPR000011; Protein modification; protein sumoylation. SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) sae1 uble1a TGas081c19.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42385_c0_g1_i8 Q06624 RHC31_YEAST 2.00E-25 GO:0019948; GO:0031510; GO:0005829; GO:0016925; GO:0006974 SUMO activating enzyme activity; SUMO activating enzyme complex; cytosol; protein sumoylation; response to DNA damage stimulus IPR009036; IPR016040; IPR000594; DNA damage tolerance protein RHC31 (RAD31 homolog) AOS1 RHC31 YPR180W P9705.5 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42386_c1_g1_i2 O02654 ENO_LOLPE 0 GO:0006096; GO:0000287; GO:0004634; GO:0000015 glycolysis; magnesium ion binding; phosphopyruvate hydratase activity; phosphopyruvate hydratase complex IPR000941; IPR020810; IPR020809; IPR020811; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5. Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR42388_c0_g1_i1 O32231 RNR_BACSU 1.00E-33 GO:0003723; GO:0016070; GO:0005737; GO:0008859; GO:0090305 RNA binding; RNA metabolic process; cytoplasm; exoribonuclease II activity; nucleic acid phosphodiester bond hydrolysis IPR011129; IPR012340; IPR003029; IPR022967; IPR013223; IPR022966; IPR004476; IPR011805; Ribonuclease R (RNase R) (EC 3.1.13.1) (VacB protein homolog) rnr vacB yvaJ BSU33610 Bacillus subtilis (strain 168) TR42388_c0_g2_i1 Q9WZI1 RNR_THEMA 1.00E-27 GO:0003723; GO:0016070; GO:0005737; GO:0008859; GO:0090305 RNA binding; RNA metabolic process; cytoplasm; exoribonuclease II activity; nucleic acid phosphodiester bond hydrolysis IPR011129; IPR012340; IPR003029; IPR022967; IPR013223; IPR022966; IPR004476; IPR011805; Ribonuclease R (RNase R) (EC 3.1.13.1) (VacB protein homolog) rnr vacB TM_0722 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR42388_c3_g1_i1 Q0V9R3 DI3L2_XENTR 6.00E-143 GO:0000175; GO:0003723; GO:0051301; GO:0000932; GO:0010587; GO:0007067; GO:0000291; GO:1990074; GO:0019827 "3'-5'-exoribonuclease activity; RNA binding; cell division; cytoplasmic mRNA processing body; miRNA catabolic process; mitosis; nuclear-transcribed mRNA catabolic process, exonucleolytic; polyuridylation-dependent mRNA catabolic process; stem cell maintenance" IPR012340; IPR022966; DIS3-like exonuclease 2 (EC 3.1.13.-) dis3l2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR4239_c0_g1_i1 Q24498 RY44_DROME 4.00E-21 GO:0005509; GO:0006874; GO:0016021; GO:0005875; GO:0007275; GO:0006936; GO:0035206; GO:0072347; GO:0005219; GO:0033017 calcium ion binding; cellular calcium ion homeostasis; integral to membrane; microtubule associated complex; multicellular organismal development; muscle contraction; regulation of hemocyte proliferation; response to anesthetic; ryanodine-sensitive calcium-release channel activity; sarcoplasmic reticulum membrane IPR001870; IPR000699; IPR008985; IPR011992; IPR014821; IPR005821; IPR016093; IPR013662; IPR013333; IPR003032; IPR015925; IPR009460; IPR018355; IPR003877; Ryanodine receptor 44F Rya-r44F dry RyR CG10844 Drosophila melanogaster (Fruit fly) TR42390_c0_g1_i1 A0JP70 WDR90_XENTR 6.00E-41 IPR007714; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 90 wdr90 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42391_c2_g1_i10 Q26474 LACH_SCHAM 2.00E-06 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Lachesin LAC Schistocerca americana (American grasshopper) TR42391_c2_g1_i13 A6NMZ7 CO6A6_HUMAN 8.00E-56 GO:0007155; GO:0005581; GO:0030574; GO:0031012; GO:0022617; GO:0005576 cell adhesion; collagen; collagen catabolic process; extracellular matrix; extracellular matrix disassembly; extracellular region IPR008160; IPR002035; Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) TR42391_c2_g1_i16 P12111 CO6A3_HUMAN 6.00E-51 GO:0007411; GO:0007155; GO:0030574; GO:0005589; GO:0005788; GO:0022617; GO:0005615; GO:0007517; GO:0042383; GO:0004867 axon guidance; cell adhesion; collagen catabolic process; collagen type VI; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular space; muscle organ development; sarcolemma; serine-type endopeptidase inhibitor activity IPR008160; IPR003961; IPR013783; IPR002223; IPR020901; IPR002035; Collagen alpha-3(VI) chain COL6A3 Homo sapiens (Human) TR42391_c2_g1_i2 A6NMZ7 CO6A6_HUMAN 8.00E-56 GO:0007155; GO:0005581; GO:0030574; GO:0031012; GO:0022617; GO:0005576 cell adhesion; collagen; collagen catabolic process; extracellular matrix; extracellular matrix disassembly; extracellular region IPR008160; IPR002035; Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) TR42391_c2_g1_i5 P21941 MATN1_HUMAN 2.00E-23 GO:0030198; GO:0005201; GO:0003429; GO:0006461; GO:0005578; GO:0030500 extracellular matrix organization; extracellular matrix structural constituent; growth plate cartilage chondrocyte morphogenesis; protein complex assembly; proteinaceous extracellular matrix; regulation of bone mineralization IPR000742; IPR013032; IPR019466; IPR002035; Cartilage matrix protein (Matrilin-1) MATN1 CMP CRTM Homo sapiens (Human) TR42391_c2_g1_i6 Q95LI2 VITRN_BOVIN 2.00E-25 GO:0005578 proteinaceous extracellular matrix IPR004043; IPR002035; Vitrin VIT Bos taurus (Bovine) TR42391_c2_g1_i9 Q60847 COCA1_MOUSE 1.00E-26 GO:0007155; GO:0005581; GO:0005615; GO:0070062 cell adhesion; collagen; extracellular space; extracellular vesicular exosome IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain Col12a1 Mus musculus (Mouse) TR42392_c1_g3_i1 Q9H8G2 CAAP1_HUMAN 4.00E-08 GO:0006915 apoptotic process Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP) CAAP1 C9orf82 CAAP Homo sapiens (Human) TR42394_c2_g1_i1 A2AFS3 K1324_MOUSE 1.00E-31 GO:0005794; GO:0005887; GO:0031902; GO:0005765; GO:0016236; GO:2001240; GO:2000786; GO:0005802 Golgi apparatus; integral to plasma membrane; late endosome membrane; lysosomal membrane; macroautophagy; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of autophagic vacuole assembly; trans-Golgi network IPR009030; IPR009011; UPF0577 protein KIAA1324 Kiaa1324 Mus musculus (Mouse) TR42394_c2_g2_i1 A8MWY0 K132L_HUMAN 2.00E-170 GO:0016021 integral to membrane IPR009030; IPR009011; UPF0577 protein KIAA1324-like (Estrogen-induced gene 121-like protein) (hEIG121L) KIAA1324L EIG121L Homo sapiens (Human) TR42395_c0_g1_i5 Q5R889 SAHH3_PONAB 0 GO:0004013; GO:0006730 adenosylhomocysteinase activity; one-carbon metabolic process IPR000043; IPR015878; IPR016040; IPR020082; Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. Putative adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2) AHCYL2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42396_c3_g2_i1 P10687 PLCB1_RAT 2.00E-109 GO:0060466; GO:0005509; GO:0021987; GO:0005829; GO:0007215; GO:0048009; GO:0035556; GO:0007612; GO:0016042; GO:0016020; GO:0007613; GO:2000438; GO:0045892; GO:0031965; GO:0016607; GO:0046488; GO:0004435; GO:2000560; GO:1900087; GO:0048639; GO:0032735; GO:0045663; GO:0045893; GO:0042803; GO:0008277; GO:0034284; GO:0043434; GO:0004871 "activation of meiosis involved in egg activation; calcium ion binding; cerebral cortex development; cytosol; glutamate receptor signaling pathway; insulin-like growth factor receptor signaling pathway; intracellular signal transduction; learning; lipid catabolic process; membrane; memory; negative regulation of monocyte extravasation; negative regulation of transcription, DNA-dependent; nuclear membrane; nuclear speck; phosphatidylinositol metabolic process; phosphatidylinositol phospholipase C activity; positive regulation of CD24 biosynthetic process; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of developmental growth; positive regulation of interleukin-12 production; positive regulation of myoblast differentiation; positive regulation of transcription, DNA-dependent; protein homodimerization activity; regulation of G-protein coupled receptor protein signaling pathway; response to monosaccharide stimulus; response to peptide hormone stimulus; signal transducer activity" IPR000008; IPR011992; IPR001192; IPR016280; IPR014815; IPR017946; IPR015359; IPR000909; IPR001711; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1)" Plcb1 Rattus norvegicus (Rat) TR42396_c6_g1_i1 P25455 PIP1_DROME 7.00E-114 GO:0005509; GO:0007629; GO:0035556; GO:0016042; GO:0004435; GO:0004871 calcium ion binding; flight behavior; intracellular signal transduction; lipid catabolic process; phosphatidylinositol phospholipase C activity; signal transducer activity IPR000008; IPR011992; IPR011993; IPR001192; IPR014815; IPR017946; IPR015359; IPR000909; IPR001711; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II (EC 3.1.4.11) (Phosphoinositide phospholipase C)" Plc21C plc-21 CG4574 Drosophila melanogaster (Fruit fly) TR42397_c0_g3_i1 Q3UHH1 K0913_MOUSE 2.00E-59 GO:0008270 zinc ion binding IPR007527; Zinc finger SWIM domain-containing protein 8 Zswim8 Kiaa0913 Mus musculus (Mouse) TR42397_c0_g3_i2 Q80TB7 ZSWM6_MOUSE 0 GO:0048812; GO:2001222; GO:0008270 neuron projection morphogenesis; regulation of neuron migration; zinc ion binding IPR007527; Zinc finger SWIM domain-containing protein 6 (Fragment) Zswim6 Kiaa1577 Mus musculus (Mouse) TR42399_c3_g1_i1 O94875 SRBS2_HUMAN 2.00E-07 GO:0030018; GO:0015629; GO:0008093; GO:0046872; GO:0005634; GO:0048471; GO:0005886; GO:0005200; GO:0008307 Q13177; Q8WX93; P63104 Z disc; actin cytoskeleton; cytoskeletal adaptor activity; metal ion binding; nucleus; perinuclear region of cytoplasm; plasma membrane; structural constituent of cytoskeleton; structural constituent of muscle IPR000108; IPR001452; IPR003127; IPR007087; Sorbin and SH3 domain-containing protein 2 (Arg/Abl-interacting protein 2) (ArgBP2) (Sorbin) SORBS2 ARGBP2 KIAA0777 Homo sapiens (Human) TR42399_c3_g1_i3 Q9XYM0 CRK_DROME 3.00E-88 GO:0005070; GO:0007298; GO:0048013; GO:0046529; GO:0007520; GO:0046330; GO:0032319; GO:0032956 Q9VCH4 "SH3/SH2 adaptor activity; border follicle cell migration; ephrin receptor signaling pathway; imaginal disc fusion, thorax closure; myoblast fusion; positive regulation of JNK cascade; regulation of Rho GTPase activity; regulation of actin cytoskeleton organization" IPR000980; IPR011511; IPR001452; Adapter molecule Crk Crk CG1587 Drosophila melanogaster (Fruit fly) TR42399_c3_g1_i4 Q9NHC3 CED2_CAEEL 7.00E-39 GO:0005070; GO:0031532; GO:0006915; GO:0016477; GO:0043652; GO:0005886; GO:0007165 SH3/SH2 adaptor activity; actin cytoskeleton reorganization; apoptotic process; cell migration; engulfment of apoptotic cell; plasma membrane; signal transduction IPR000980; IPR011511; IPR001452; Cell death abnormality protein 2 (Cell-corpse engulfment protein CED-2) ced-2 Y41D4B.13 Caenorhabditis elegans TR42399_c3_g1_i5 Q99M51 NCK1_MOUSE 4.00E-09 GO:0042110; GO:0007015; GO:0016477; GO:0005783; GO:0030032; GO:0060548; GO:0005634; GO:0042102; GO:0030838; GO:0045944; GO:0004860; GO:0006417; GO:0051707; GO:0012506 P00520; P97465 T cell activation; actin filament organization; cell migration; endoplasmic reticulum; lamellipodium assembly; negative regulation of cell death; nucleus; positive regulation of T cell proliferation; positive regulation of actin filament polymerization; positive regulation of transcription from RNA polymerase II promoter; protein kinase inhibitor activity; regulation of translation; response to other organism; vesicle membrane IPR017304; IPR000980; IPR001452; Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1) Nck1 Mus musculus (Mouse) TR42399_c3_g1_i6 Q3UTJ2 SRBS2_MOUSE 2.00E-07 GO:0030018; GO:0005856; GO:0005925; GO:0046872; GO:0048471; GO:0005886 Z disc; cytoskeleton; focal adhesion; metal ion binding; perinuclear region of cytoplasm; plasma membrane IPR000108; IPR001452; IPR003127; IPR007087; Sorbin and SH3 domain-containing protein 2 (Arg/Abl-interacting protein 2) (ArgBP2) Sorbs2 Argbp2 Kiaa0777 Mus musculus (Mouse) TR42399_c3_g1_i7 Q9Z0R6 ITSN2_MOUSE 1.00E-08 GO:0005089; GO:0005509; GO:0005737; GO:0006897; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; calcium ion binding; cytoplasm; endocytosis; phospholipid binding; regulation of Rho protein signal transduction IPR000008; IPR000219; IPR011992; IPR018247; IPR002048; IPR000261; IPR027029; IPR000108; IPR011993; IPR001849; IPR011511; IPR001452; Intersectin-2 (EH domain and SH3 domain regulator of endocytosis 2) (EH and SH3 domains protein 2) (SH3 domain-containing protein 1B) Itsn2 Ese2 Sh3d1B Mus musculus (Mouse) TR42399_c3_g1_i9 Q9XYM0 CRK_DROME 2.00E-86 GO:0005070; GO:0007298; GO:0048013; GO:0046529; GO:0007520; GO:0046330; GO:0032319; GO:0032956 Q9VCH4 "SH3/SH2 adaptor activity; border follicle cell migration; ephrin receptor signaling pathway; imaginal disc fusion, thorax closure; myoblast fusion; positive regulation of JNK cascade; regulation of Rho GTPase activity; regulation of actin cytoskeleton organization" IPR000980; IPR011511; IPR001452; Adapter molecule Crk Crk CG1587 Drosophila melanogaster (Fruit fly) TR42402_c0_g1_i12 Q9Z0P7 SUFU_MOUSE 0 GO:0008013; GO:0005737; GO:0042994; GO:0001947; GO:2000059; GO:1901621; GO:0000122; GO:0001843; GO:0005634; GO:0072372; GO:0043588; GO:0021776; GO:0021775; GO:0008134 P16110; O88907; P50636; O55128 beta-catenin binding; cytoplasm; cytoplasmic sequestering of transcription factor; heart looping; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; negative regulation of transcription from RNA polymerase II promoter; neural tube closure; nucleus; primary cilium; skin development; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; smoothened signaling pathway involved in ventral spinal cord interneuron specification; transcription factor binding IPR020941; IPR024314; IPR007768; IPR016591; Suppressor of fused homolog Sufu Mus musculus (Mouse) TR42402_c0_g1_i13 Q9Z0P7 SUFU_MOUSE 0 GO:0008013; GO:0005737; GO:0042994; GO:0001947; GO:2000059; GO:1901621; GO:0000122; GO:0001843; GO:0005634; GO:0072372; GO:0043588; GO:0021776; GO:0021775; GO:0008134 P16110; O88907; P50636; O55128 beta-catenin binding; cytoplasm; cytoplasmic sequestering of transcription factor; heart looping; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; negative regulation of transcription from RNA polymerase II promoter; neural tube closure; nucleus; primary cilium; skin development; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; smoothened signaling pathway involved in ventral spinal cord interneuron specification; transcription factor binding IPR020941; IPR024314; IPR007768; IPR016591; Suppressor of fused homolog Sufu Mus musculus (Mouse) TR42402_c0_g1_i2 Q9Z0P7 SUFU_MOUSE 0 GO:0008013; GO:0005737; GO:0042994; GO:0001947; GO:2000059; GO:1901621; GO:0000122; GO:0001843; GO:0005634; GO:0072372; GO:0043588; GO:0021776; GO:0021775; GO:0008134 P16110; O88907; P50636; O55128 beta-catenin binding; cytoplasm; cytoplasmic sequestering of transcription factor; heart looping; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; negative regulation of transcription from RNA polymerase II promoter; neural tube closure; nucleus; primary cilium; skin development; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; smoothened signaling pathway involved in ventral spinal cord interneuron specification; transcription factor binding IPR020941; IPR024314; IPR007768; IPR016591; Suppressor of fused homolog Sufu Mus musculus (Mouse) TR42402_c0_g1_i8 Q9Z0P7 SUFU_MOUSE 0 GO:0008013; GO:0005737; GO:0042994; GO:0001947; GO:2000059; GO:1901621; GO:0000122; GO:0001843; GO:0005634; GO:0072372; GO:0043588; GO:0021776; GO:0021775; GO:0008134 P16110; O88907; P50636; O55128 beta-catenin binding; cytoplasm; cytoplasmic sequestering of transcription factor; heart looping; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; negative regulation of transcription from RNA polymerase II promoter; neural tube closure; nucleus; primary cilium; skin development; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; smoothened signaling pathway involved in ventral spinal cord interneuron specification; transcription factor binding IPR020941; IPR024314; IPR007768; IPR016591; Suppressor of fused homolog Sufu Mus musculus (Mouse) TR42403_c4_g2_i1 Q9CZR2 NALD2_MOUSE 2.00E-78 GO:0050129; GO:0004180; GO:0016805; GO:0016021; GO:0046872; GO:0008237; GO:0042135; GO:0006508 N-formylglutamate deformylase activity; carboxypeptidase activity; dipeptidase activity; integral to membrane; metal ion binding; metallopeptidase activity; neurotransmitter catabolic process; proteolysis IPR007484; IPR003137; IPR007365; N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylaspartylglutamate peptidase II) (NAAG-peptidase II) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) Naalad2 Mus musculus (Mouse) TR42403_c4_g2_i2 Q9M1S8 GCP2_ARATH 8.00E-42 GO:0009790; GO:0009908; GO:0016021; GO:0010305; GO:0046872; GO:0004181; GO:0009640; GO:0006508; GO:0010080; GO:0010081; GO:0010082 O04379 embryo development; flower development; integral to membrane; leaf vascular tissue pattern formation; metal ion binding; metallocarboxypeptidase activity; photomorphogenesis; proteolysis; regulation of floral meristem growth; regulation of inflorescence meristem growth; regulation of root meristem growth IPR007484; IPR007365; Probable glutamate carboxypeptidase 2 (EC 3.4.17.21) (Probable glutamate carboxypeptidase II) AMP1 At3g54720 T5N23_80 Arabidopsis thaliana (Mouse-ear cress) TR42403_c4_g3_i3 Q9Y3Q0 NALD2_HUMAN 2.00E-30 GO:0050129; GO:0004180; GO:0016805; GO:0008239; GO:0016021; GO:0046872; GO:0008237; GO:0042135; GO:0006508; GO:0008236 N-formylglutamate deformylase activity; carboxypeptidase activity; dipeptidase activity; dipeptidyl-peptidase activity; integral to membrane; metal ion binding; metallopeptidase activity; neurotransmitter catabolic process; proteolysis; serine-type peptidase activity IPR007484; IPR003137; IPR007365; N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) NAALAD2 Homo sapiens (Human) TR42403_c4_g3_i4 P70627 FOLH1_RAT 3.00E-29 GO:0004180; GO:0016805; GO:0016021; GO:0046872; GO:0008237; GO:0005886; GO:0006508 carboxypeptidase activity; dipeptidase activity; integral to membrane; metal ion binding; metallopeptidase activity; plasma membrane; proteolysis IPR007484; IPR003137; IPR007365; Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Folate hydrolase 1) (Folylpoly-gamma-glutamate carboxypeptidase) (FGCP) (Glutamate carboxypeptidase II) (GCPII) (Membrane glutamate carboxypeptidase) (mGCP) (N-acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Prostate-specific membrane antigen homolog) (Pteroylpoly-gamma-glutamate carboxypeptidase) Folh1 Naalad1 Rattus norvegicus (Rat) TR42403_c4_g3_i5 Q9M1S8 GCP2_ARATH 4.00E-10 GO:0009790; GO:0009908; GO:0016021; GO:0010305; GO:0046872; GO:0004181; GO:0009640; GO:0006508; GO:0010080; GO:0010081; GO:0010082 O04379 embryo development; flower development; integral to membrane; leaf vascular tissue pattern formation; metal ion binding; metallocarboxypeptidase activity; photomorphogenesis; proteolysis; regulation of floral meristem growth; regulation of inflorescence meristem growth; regulation of root meristem growth IPR007484; IPR007365; Probable glutamate carboxypeptidase 2 (EC 3.4.17.21) (Probable glutamate carboxypeptidase II) AMP1 At3g54720 T5N23_80 Arabidopsis thaliana (Mouse-ear cress) TR42404_c1_g2_i1 Q63ZQ1 SEP2B_XENLA 1.00E-180 GO:0005525; GO:0051301; GO:0042384; GO:0060170; GO:0032154; GO:0005737; GO:0030496; GO:0007067; GO:0031105; GO:0007224; GO:0005819 GTP binding; cell division; cilium assembly; cilium membrane; cleavage furrow; cytoplasm; midbody; mitosis; septin complex; smoothened signaling pathway; spindle IPR000038; IPR027417; IPR016491; IPR008113; Septin-2B sept2-b Xenopus laevis (African clawed frog) TR42404_c1_g2_i3 A2BGU8 SEPT3_DANRE 5.00E-95 GO:0005525; GO:0007049; GO:0031105 GTP binding; cell cycle; septin complex IPR000038; IPR027417; IPR016491; IPR008114; Neuronal-specific septin-3 sept3 si:dkey-48a12.1 zgc:110051 Danio rerio (Zebrafish) (Brachydanio rerio) TR42404_c1_g2_i4 Q5ZMH1 SEPT2_CHICK 0 GO:0005525; GO:0051301; GO:0042384; GO:0060170; GO:0032154; GO:0005737; GO:0030496; GO:0007067; GO:0031105; GO:0007224; GO:0005819 GTP binding; cell division; cilium assembly; cilium membrane; cleavage furrow; cytoplasm; midbody; mitosis; septin complex; smoothened signaling pathway; spindle IPR000038; IPR027417; IPR016491; IPR008113; Septin-2 SEPT2 RCJMB04_2a21 Gallus gallus (Chicken) TR42404_c1_g2_i5 P42207 SEPT1_DROME 0 GO:0005525; GO:0003924; GO:0007049; GO:0051301; GO:0007349; GO:0045172; GO:0005875; GO:0043065; GO:0031105; GO:0005940 GTP binding; GTPase activity; cell cycle; cell division; cellularization; germline ring canal; microtubule associated complex; positive regulation of apoptotic process; septin complex; septin ring IPR000038; IPR027417; IPR016491; Septin-1 (DIFF6 protein homolog) (Protein innocent bystander) Sep1 Diff6 iby CG1403 Drosophila melanogaster (Fruit fly) TR42404_c1_g2_i6 Q80UG5 SEPT9_MOUSE 1.00E-88 GO:0005525; GO:0007049; GO:0051301; GO:0005874; GO:0048471; GO:0051291; GO:0001725 GTP binding; cell cycle; cell division; microtubule; perinuclear region of cytoplasm; protein heterooligomerization; stress fiber IPR000038; IPR027417; Septin-9 (SL3-3 integration site 1 protein) Sept9 Kiaa0991 Sint1 Mus musculus (Mouse) TR42404_c1_g2_i7 Q4V8G5 SEP12_RAT 3.00E-85 GO:0005525; GO:0007049; GO:0051301; GO:0030496; GO:0048471; GO:0042803; GO:0031105; GO:0097227; GO:0005819 GTP binding; cell cycle; cell division; midbody; perinuclear region of cytoplasm; protein homodimerization activity; septin complex; sperm annulus; spindle IPR000038; IPR027417; IPR016491; Septin-12 12-Sep Rattus norvegicus (Rat) TR42404_c1_g2_i8 Q9Z1S5 SEPT3_MOUSE 2.00E-97 GO:0005525; GO:0007049; GO:0051301; GO:0030054; GO:0031105; GO:0045202 GTP binding; cell cycle; cell division; cell junction; septin complex; synapse IPR000038; IPR027417; IPR016491; IPR008114; Neuronal-specific septin-3 Sept3 Sep3 Mus musculus (Mouse) TR42404_c1_g2_i9 P42207 SEPT1_DROME 2.00E-179 GO:0005525; GO:0003924; GO:0007049; GO:0051301; GO:0007349; GO:0045172; GO:0005875; GO:0043065; GO:0031105; GO:0005940 GTP binding; GTPase activity; cell cycle; cell division; cellularization; germline ring canal; microtubule associated complex; positive regulation of apoptotic process; septin complex; septin ring IPR000038; IPR027417; IPR016491; Septin-1 (DIFF6 protein homolog) (Protein innocent bystander) Sep1 Diff6 iby CG1403 Drosophila melanogaster (Fruit fly) TR42405_c2_g6_i1 P49096 CYB5_MUSDO 4.00E-39 GO:0005789; GO:0020037; GO:0016021; GO:0046872; GO:0055114 endoplasmic reticulum membrane; heme binding; integral to membrane; metal ion binding; oxidation-reduction process IPR001199; IPR018506; Cytochrome b5 (CYTB5) Cyt-b5 Musca domestica (House fly) TR42406_c0_g2_i1 Q6UPE0 CHDH_RAT 0 GO:0008812; GO:0050660; GO:0019285; GO:0005743 choline dehydrogenase activity; flavin adenine dinucleotide binding; glycine betaine biosynthetic process from choline; mitochondrial inner membrane IPR012132; IPR000172; IPR007867; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. "Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)" Chdh Rattus norvegicus (Rat) TR42406_c0_g2_i2 Q9VGP2 NINAG_DROME 2.00E-24 GO:0006066; GO:0008812; GO:0005576; GO:0050660; GO:0016491; GO:0050896; GO:0001523; GO:0046154; GO:0006810; GO:0007601 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding; oxidoreductase activity; response to stimulus; retinoid metabolic process; rhodopsin metabolic process; transport; visual perception IPR012132; IPR000172; IPR007867; Neither inactivation nor afterpotential protein G (EC 1.-.-.-) ninaG CG6728 Drosophila melanogaster (Fruit fly) TR42406_c0_g2_i3 Q6UPE0 CHDH_RAT 0 GO:0008812; GO:0050660; GO:0019285; GO:0005743 choline dehydrogenase activity; flavin adenine dinucleotide binding; glycine betaine biosynthetic process from choline; mitochondrial inner membrane IPR012132; IPR000172; IPR007867; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. "Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)" Chdh Rattus norvegicus (Rat) TR42406_c0_g2_i4 Q9VGP2 NINAG_DROME 2.00E-22 GO:0006066; GO:0008812; GO:0005576; GO:0050660; GO:0016491; GO:0050896; GO:0001523; GO:0046154; GO:0006810; GO:0007601 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding; oxidoreductase activity; response to stimulus; retinoid metabolic process; rhodopsin metabolic process; transport; visual perception IPR012132; IPR000172; IPR007867; Neither inactivation nor afterpotential protein G (EC 1.-.-.-) ninaG CG6728 Drosophila melanogaster (Fruit fly) TR42407_c0_g1_i2 P97526 NF1_RAT 0 GO:0000165; GO:0005099; GO:0007265; GO:0030036; GO:0030325; GO:0048844; GO:0030424; GO:0048593; GO:0021987; GO:0030199; GO:0005737; GO:0030425; GO:0021897; GO:0048853; GO:0007507; GO:0031235; GO:0001889; GO:0001656; GO:0008017; GO:0022011; GO:0043407; GO:0046580; GO:0048147; GO:0007406; GO:0048715; GO:0042992; GO:0005634; GO:0001649; GO:0014065; GO:0043473; GO:0045762; GO:0043525; GO:0014069; GO:0043234; GO:0045765; GO:0045124; GO:0001952; GO:0045664; GO:0001666; GO:0048745; GO:0021510; GO:0048485; GO:0008542; GO:0042060 MAPK cascade; Ras GTPase activator activity; Ras protein signal transduction; actin cytoskeleton organization; adrenal gland development; artery morphogenesis; axon; camera-type eye morphogenesis; cerebral cortex development; collagen fibril organization; cytoplasm; dendrite; forebrain astrocyte development; forebrain morphogenesis; heart development; intrinsic to internal side of plasma membrane; liver development; metanephros development; microtubule binding; myelination in peripheral nervous system; negative regulation of MAP kinase activity; negative regulation of Ras protein signal transduction; negative regulation of fibroblast proliferation; negative regulation of neuroblast proliferation; negative regulation of oligodendrocyte differentiation; negative regulation of transcription factor import into nucleus; nucleus; osteoblast differentiation; phosphatidylinositol 3-kinase cascade; pigmentation; positive regulation of adenylate cyclase activity; positive regulation of neuron apoptotic process; postsynaptic density; protein complex; regulation of angiogenesis; regulation of bone resorption; regulation of cell-matrix adhesion; regulation of neuron differentiation; response to hypoxia; smooth muscle tissue development; spinal cord development; sympathetic nervous system development; visual learning; wound healing IPR011989; IPR016024; IPR001251; IPR001936; IPR023152; IPR008936; Neurofibromin (Neurofibromatosis-related protein NF-1) Nf1 Rattus norvegicus (Rat) TR42407_c0_g1_i3 P97526 NF1_RAT 0 GO:0000165; GO:0005099; GO:0007265; GO:0030036; GO:0030325; GO:0048844; GO:0030424; GO:0048593; GO:0021987; GO:0030199; GO:0005737; GO:0030425; GO:0021897; GO:0048853; GO:0007507; GO:0031235; GO:0001889; GO:0001656; GO:0008017; GO:0022011; GO:0043407; GO:0046580; GO:0048147; GO:0007406; GO:0048715; GO:0042992; GO:0005634; GO:0001649; GO:0014065; GO:0043473; GO:0045762; GO:0043525; GO:0014069; GO:0043234; GO:0045765; GO:0045124; GO:0001952; GO:0045664; GO:0001666; GO:0048745; GO:0021510; GO:0048485; GO:0008542; GO:0042060 MAPK cascade; Ras GTPase activator activity; Ras protein signal transduction; actin cytoskeleton organization; adrenal gland development; artery morphogenesis; axon; camera-type eye morphogenesis; cerebral cortex development; collagen fibril organization; cytoplasm; dendrite; forebrain astrocyte development; forebrain morphogenesis; heart development; intrinsic to internal side of plasma membrane; liver development; metanephros development; microtubule binding; myelination in peripheral nervous system; negative regulation of MAP kinase activity; negative regulation of Ras protein signal transduction; negative regulation of fibroblast proliferation; negative regulation of neuroblast proliferation; negative regulation of oligodendrocyte differentiation; negative regulation of transcription factor import into nucleus; nucleus; osteoblast differentiation; phosphatidylinositol 3-kinase cascade; pigmentation; positive regulation of adenylate cyclase activity; positive regulation of neuron apoptotic process; postsynaptic density; protein complex; regulation of angiogenesis; regulation of bone resorption; regulation of cell-matrix adhesion; regulation of neuron differentiation; response to hypoxia; smooth muscle tissue development; spinal cord development; sympathetic nervous system development; visual learning; wound healing IPR011989; IPR016024; IPR001251; IPR001936; IPR023152; IPR008936; Neurofibromin (Neurofibromatosis-related protein NF-1) Nf1 Rattus norvegicus (Rat) TR42407_c0_g1_i7 Q54Y08 NGAP_DICDI 1.00E-21 GO:0005099; GO:0005813; GO:0005737; GO:0031235; GO:0046580; GO:0007165 Ras GTPase activator activity; centrosome; cytoplasm; intrinsic to internal side of plasma membrane; negative regulation of Ras protein signal transduction; signal transduction IPR000008; IPR001936; IPR023152; IPR008936; Probable Ras GTPase-activating-like protein ngap (DdNGAP) ngap DDB_G0278483 Dictyostelium discoideum (Slime mold) TR42407_c0_g1_i8 P21359 NF1_HUMAN 8.00E-52 GO:0000165; GO:0005099; GO:0007265; GO:0030036; GO:0030325; GO:0048844; GO:0030424; GO:0048593; GO:0021987; GO:0030199; GO:0005737; GO:0030425; GO:0021897; GO:0048853; GO:0007507; GO:0031235; GO:0001889; GO:0001656; GO:0022011; GO:0043407; GO:0035021; GO:0046580; GO:0016525; GO:0048712; GO:0030336; GO:0001953; GO:0001937; GO:0048147; GO:0007406; GO:0046929; GO:0048715; GO:0045671; GO:0042992; GO:0021915; GO:0005634; GO:0001649; GO:0014065; GO:0043473; GO:0045762; GO:0001938; GO:0043525; GO:0045765; GO:0043535; GO:0045124; GO:0001952; GO:0048169; GO:0032228; GO:0001666; GO:0007519; GO:0048745; GO:0021510; GO:0048485; GO:0008542; GO:0042060 P05067; P34741 "MAPK cascade; Ras GTPase activator activity; Ras protein signal transduction; actin cytoskeleton organization; adrenal gland development; artery morphogenesis; axon; camera-type eye morphogenesis; cerebral cortex development; collagen fibril organization; cytoplasm; dendrite; forebrain astrocyte development; forebrain morphogenesis; heart development; intrinsic to internal side of plasma membrane; liver development; metanephros development; myelination in peripheral nervous system; negative regulation of MAP kinase activity; negative regulation of Rac protein signal transduction; negative regulation of Ras protein signal transduction; negative regulation of angiogenesis; negative regulation of astrocyte differentiation; negative regulation of cell migration; negative regulation of cell-matrix adhesion; negative regulation of endothelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of neuroblast proliferation; negative regulation of neurotransmitter secretion; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of transcription factor import into nucleus; neural tube development; nucleus; osteoblast differentiation; phosphatidylinositol 3-kinase cascade; pigmentation; positive regulation of adenylate cyclase activity; positive regulation of endothelial cell proliferation; positive regulation of neuron apoptotic process; regulation of angiogenesis; regulation of blood vessel endothelial cell migration; regulation of bone resorption; regulation of cell-matrix adhesion; regulation of long-term neuronal synaptic plasticity; regulation of synaptic transmission, GABAergic; response to hypoxia; skeletal muscle tissue development; smooth muscle tissue development; spinal cord development; sympathetic nervous system development; visual learning; wound healing" IPR011989; IPR016024; IPR001251; IPR001936; IPR023152; IPR008936; Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] NF1 Homo sapiens (Human) TR42408_c0_g1_i1 Q54Y26 NDRA_DICDI 1.00E-36 GO:0005524; GO:0005813; GO:0005737; GO:0072686; GO:0060100; GO:0004674 "ATP binding; centrosome; cytoplasm; mitotic spindle; positive regulation of phagocytosis, engulfment; protein serine/threonine kinase activity" IPR000961; IPR011009; IPR011993; IPR000719; IPR017441; IPR002290; IPR008271; Probable serine/threonine-protein kinase ndrA (EC 2.7.11.1) (Nuclear DBF2-related kinase A) ndrA DDB_G0278457 Dictyostelium discoideum (Slime mold) TR42408_c0_g2_i1 Q8MIT6 ROCK1_BOVIN 3.00E-44 GO:0005524; GO:0000139; GO:0032059; GO:0005814; GO:0030027; GO:0005886; GO:0004674; GO:0001726 ATP binding; Golgi membrane; bleb; centriole; lamellipodium; plasma membrane; protein serine/threonine kinase activity; ruffle IPR020684; IPR015008; "Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) (Fragment)" ROCK1 Bos taurus (Bovine) TR42408_c0_g2_i2 Q28021 ROCK2_BOVIN 0 GO:0005524; GO:0030036; GO:0005829; GO:0035556; GO:0046872; GO:0005815; GO:0005634; GO:0005543; GO:0005886; GO:0004672; GO:0004674 ATP binding; actin cytoskeleton organization; cytosol; intracellular signal transduction; metal ion binding; microtubule organizing center; nucleus; phospholipid binding; plasma membrane; protein kinase activity; protein serine/threonine kinase activity IPR000961; IPR011072; IPR011009; IPR011993; IPR001849; IPR002219; IPR000719; IPR017441; IPR020684; IPR015008; IPR002290; IPR008271; "Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)" ROCK2 Bos taurus (Bovine) TR42408_c0_g2_i3 Q28021 ROCK2_BOVIN 0 GO:0005524; GO:0030036; GO:0005829; GO:0035556; GO:0046872; GO:0005815; GO:0005634; GO:0005543; GO:0005886; GO:0004672; GO:0004674 ATP binding; actin cytoskeleton organization; cytosol; intracellular signal transduction; metal ion binding; microtubule organizing center; nucleus; phospholipid binding; plasma membrane; protein kinase activity; protein serine/threonine kinase activity IPR000961; IPR011072; IPR011009; IPR011993; IPR001849; IPR002219; IPR000719; IPR017441; IPR020684; IPR015008; IPR002290; IPR008271; "Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)" ROCK2 Bos taurus (Bovine) TR42409_c4_g1_i11 P32519 ELF1_HUMAN 6.00E-16 GO:0005737; GO:0050860; GO:0005634; GO:0045944; GO:0001817; GO:0043565; GO:0003700; GO:0006351 P31276; P08047 "cytoplasm; negative regulation of T cell receptor signaling pathway; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of cytokine production; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR022084; IPR011991; ETS-related transcription factor Elf-1 (E74-like factor 1) ELF1 Homo sapiens (Human) TR42409_c4_g1_i12 P41156 ETS1_RAT 4.00E-80 GO:0060055; GO:0070301; GO:0060206; GO:0007565; GO:0021854; GO:0005634; GO:0021983; GO:0045766; GO:0008284; GO:0010595; GO:0045648; GO:0045944; GO:0045893; GO:0010715; GO:0032355; GO:0001666; GO:0070555; GO:0034616; GO:0009612; GO:0043565; GO:0003700; GO:0005667; GO:0006351 "angiogenesis involved in wound healing; cellular response to hydrogen peroxide; estrous cycle phase; female pregnancy; hypothalamus development; nucleus; pituitary gland development; positive regulation of angiogenesis; positive regulation of cell proliferation; positive regulation of endothelial cell migration; positive regulation of erythrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of extracellular matrix disassembly; response to estradiol stimulus; response to hypoxia; response to interleukin-1; response to laminar fluid shear stress; response to mechanical stimulus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR016311; IPR011991; Protein C-ets-1 (p54) Ets1 Ets-1 Rattus norvegicus (Rat) TR42409_c4_g1_i13 P41156 ETS1_RAT 4.00E-80 GO:0060055; GO:0070301; GO:0060206; GO:0007565; GO:0021854; GO:0005634; GO:0021983; GO:0045766; GO:0008284; GO:0010595; GO:0045648; GO:0045944; GO:0045893; GO:0010715; GO:0032355; GO:0001666; GO:0070555; GO:0034616; GO:0009612; GO:0043565; GO:0003700; GO:0005667; GO:0006351 "angiogenesis involved in wound healing; cellular response to hydrogen peroxide; estrous cycle phase; female pregnancy; hypothalamus development; nucleus; pituitary gland development; positive regulation of angiogenesis; positive regulation of cell proliferation; positive regulation of endothelial cell migration; positive regulation of erythrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of extracellular matrix disassembly; response to estradiol stimulus; response to hypoxia; response to interleukin-1; response to laminar fluid shear stress; response to mechanical stimulus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR016311; IPR011991; Protein C-ets-1 (p54) Ets1 Ets-1 Rattus norvegicus (Rat) TR42409_c4_g1_i5 P41156 ETS1_RAT 4.00E-80 GO:0060055; GO:0070301; GO:0060206; GO:0007565; GO:0021854; GO:0005634; GO:0021983; GO:0045766; GO:0008284; GO:0010595; GO:0045648; GO:0045944; GO:0045893; GO:0010715; GO:0032355; GO:0001666; GO:0070555; GO:0034616; GO:0009612; GO:0043565; GO:0003700; GO:0005667; GO:0006351 "angiogenesis involved in wound healing; cellular response to hydrogen peroxide; estrous cycle phase; female pregnancy; hypothalamus development; nucleus; pituitary gland development; positive regulation of angiogenesis; positive regulation of cell proliferation; positive regulation of endothelial cell migration; positive regulation of erythrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of extracellular matrix disassembly; response to estradiol stimulus; response to hypoxia; response to interleukin-1; response to laminar fluid shear stress; response to mechanical stimulus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR016311; IPR011991; Protein C-ets-1 (p54) Ets1 Ets-1 Rattus norvegicus (Rat) TR42409_c4_g1_i7 P32519 ELF1_HUMAN 6.00E-16 GO:0005737; GO:0050860; GO:0005634; GO:0045944; GO:0001817; GO:0043565; GO:0003700; GO:0006351 P31276; P08047 "cytoplasm; negative regulation of T cell receptor signaling pathway; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of cytokine production; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR022084; IPR011991; ETS-related transcription factor Elf-1 (E74-like factor 1) ELF1 Homo sapiens (Human) TR42409_c4_g1_i8 P41156 ETS1_RAT 4.00E-80 GO:0060055; GO:0070301; GO:0060206; GO:0007565; GO:0021854; GO:0005634; GO:0021983; GO:0045766; GO:0008284; GO:0010595; GO:0045648; GO:0045944; GO:0045893; GO:0010715; GO:0032355; GO:0001666; GO:0070555; GO:0034616; GO:0009612; GO:0043565; GO:0003700; GO:0005667; GO:0006351 "angiogenesis involved in wound healing; cellular response to hydrogen peroxide; estrous cycle phase; female pregnancy; hypothalamus development; nucleus; pituitary gland development; positive regulation of angiogenesis; positive regulation of cell proliferation; positive regulation of endothelial cell migration; positive regulation of erythrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of extracellular matrix disassembly; response to estradiol stimulus; response to hypoxia; response to interleukin-1; response to laminar fluid shear stress; response to mechanical stimulus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR016311; IPR011991; Protein C-ets-1 (p54) Ets1 Ets-1 Rattus norvegicus (Rat) TR42410_c1_g1_i1 Q91Y63 S13A3_MOUSE 9.00E-115 GO:0015362; GO:0016021; GO:0016020; GO:0005886 high affinity sodium:dicarboxylate symporter activity; integral to membrane; membrane; plasma membrane IPR001898; Solute carrier family 13 member 3 (Na(+)/dicarboxylate cotransporter 3) (NaDC-3) (mNaDC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) Slc13a3 Nadc3 Sdct2 Mus musculus (Mouse) TR42410_c1_g1_i5 Q91Y63 S13A3_MOUSE 5.00E-114 GO:0015362; GO:0016021; GO:0016020; GO:0005886 high affinity sodium:dicarboxylate symporter activity; integral to membrane; membrane; plasma membrane IPR001898; Solute carrier family 13 member 3 (Na(+)/dicarboxylate cotransporter 3) (NaDC-3) (mNaDC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) Slc13a3 Nadc3 Sdct2 Mus musculus (Mouse) TR42413_c1_g1_i1 Q6BPK1 MED14_DEBHA 2.00E-06 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR013947; Mediator of RNA polymerase II transcription subunit 14 (Mediator complex subunit 14) RGR1 MED14 DEHA2E12958g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR42413_c1_g2_i1 O60244 MED14_HUMAN 0 GO:0001104; GO:0030521; GO:0030374; GO:0016592; GO:0045944; GO:0004872; GO:0019827; GO:0046966; GO:0006367; GO:0042809 P00519; P06241; P62993; P16333 RNA polymerase II transcription cofactor activity; androgen receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; positive regulation of transcription from RNA polymerase II promoter; receptor activity; stem cell maintenance; thyroid hormone receptor binding; transcription initiation from RNA polymerase II promoter; vitamin D receptor binding IPR013947; Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) MED14 ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170 Homo sapiens (Human) TR42413_c1_g2_i2 Q61IR6 MED14_CAEBR 1.00E-47 GO:0001104; GO:0016592 RNA polymerase II transcription cofactor activity; mediator complex IPR013947; Mediator of RNA polymerase II transcription subunit 14 (Mediator complex subunit 14) (Mediator complex subunit rgr-1) rgr-1 CBG10098 Caenorhabditis briggsae TR42413_c1_g2_i3 Q9SR02 MED14_ARATH 7.00E-13 GO:0001104; GO:0016592; GO:0007275; GO:0009506; GO:0008284; GO:0040008; GO:0009627 RNA polymerase II transcription cofactor activity; mediator complex; multicellular organismal development; plasmodesma; positive regulation of cell proliferation; regulation of growth; systemic acquired resistance IPR013947; Mediator of RNA polymerase II transcription subunit 14 (Protein STRUWWELPETER) (AtSWP) MED14 MED14_1 SWP At3g04740 F7O18.23 Arabidopsis thaliana (Mouse-ear cress) TR42413_c1_g2_i4 A2ABV5 MED14_MOUSE 5.00E-99 GO:0001104; GO:0030521; GO:0016592; GO:0045944; GO:0004872; GO:0019827; GO:0003713; GO:0006367 RNA polymerase II transcription cofactor activity; androgen receptor signaling pathway; mediator complex; positive regulation of transcription from RNA polymerase II promoter; receptor activity; stem cell maintenance; transcription coactivator activity; transcription initiation from RNA polymerase II promoter IPR013947; Mediator of RNA polymerase II transcription subunit 14 (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) Med14 Crsp2 Gm641 Trap170 Mus musculus (Mouse) TR42413_c3_g1_i1 Q9UQK1 PPR3C_HUMAN 2.00E-06 GO:0005978; GO:0004722 O95278 glycogen biosynthetic process; protein serine/threonine phosphatase activity IPR005036; IPR017434; Protein phosphatase 1 regulatory subunit 3C (Protein phosphatase 1 regulatory subunit 5) (PP1 subunit R5) (Protein targeting to glycogen) (PTG) PPP1R3C PPP1R5 Homo sapiens (Human) TR42414_c3_g1_i1 P29176 FOSX_MSVFR 3.00E-10 GO:0042025; GO:0005634; GO:0043565; GO:0003700 host cell nucleus; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR004827; IPR000837; Transforming protein v-Fos/v-Fox FOS-FOX FBR murine osteosarcoma virus (FBR-MSV) (Finkel-Biskis-Reilly murine osteosarcoma virus) TR42414_c4_g1_i1 Q9R9J1 MYCA_BACIU 9.00E-88 GO:0017000; GO:0016874; GO:0031177; GO:0030170; GO:0008483 antibiotic biosynthetic process; ligase activity; phosphopantetheine binding; pyridoxal phosphate binding; transaminase activity IPR010071; IPR009081; IPR005814; IPR025110; IPR020845; IPR000873; IPR001242; IPR018201; IPR014031; IPR014030; IPR020806; IPR006162; IPR015424; IPR015421; IPR015422; IPR016039; IPR016038; Mycosubtilin synthase subunit A (EC 2.3.1.-) [Includes: Glutamate-1-semialdehyde aminotransferase (GSA-AT); ATP-dependent asparagine adenylase 1 (AsnA 1) (Asparagine activase 1)] mycA Bacillus subtilis TR42414_c4_g1_i2 P40806 PKSJ_BACSU 9.00E-91 GO:0017000; GO:0005737; GO:0016874; GO:0031177; GO:0016746 "antibiotic biosynthetic process; cytoplasm; ligase activity; phosphopantetheine binding; transferase activity, transferring acyl groups" IPR010071; IPR009081; IPR025110; IPR020845; IPR000873; IPR001242; IPR018201; IPR014031; IPR014030; IPR016040; IPR020842; IPR020841; IPR020807; IPR013968; IPR020806; IPR006162; IPR016039; IPR016038; Antibiotic biosynthesis; bacillaene biosynthesis. Polyketide synthase PksJ (PKS) pksJ pksK BSU17180 Bacillus subtilis (strain 168) TR42414_c4_g1_i3 Q0VZ70 CHSAD_CHOCO 6.00E-23 GO:0043042; GO:0016788; GO:0016874; GO:0016310; GO:0009403; GO:0016772 "amino acid adenylylation by nonribosomal peptide synthase; hydrolase activity, acting on ester bonds; ligase activity; phosphorylation; toxin biosynthetic process; transferase activity, transferring phosphorus-containing groups" IPR010071; IPR009081; IPR025110; IPR020845; IPR000873; IPR001242; IPR000253; IPR010060; IPR008279; IPR006162; IPR001031; Chondramide synthase cmdD [Includes: ATP-dependent phenylalanine adenylase (PheA) (Phenylalanine activase); ATP-dependent tyrosine adenylase (TrpA) (Tyrosine activase)] cmdD Chondromyces crocatus TR42414_c5_g1_i1 O68006 BACA_BACLI 4.00E-17 GO:0017000; GO:0008881; GO:0016874 antibiotic biosynthetic process; glutamate racemase activity; ligase activity IPR010071; IPR009081; IPR025110; IPR020845; IPR000873; IPR001242; IPR013624; IPR010060; IPR006162; Antibiotic biosynthesis; bacitracin biosynthesis. Bacitracin synthase 1 (BA1) [Includes: ATP-dependent cysteine adenylase (CysA) (Cysteine activase); ATP-dependent leucine adenylase (LeuA) (Leucine activase); ATP-dependent glutamate adenylase (GluA) (Glutamate activase); ATP-dependent isoleucine adenylase (IleA) (Isoleucine activase); Glutamate racemase (EC 5.1.1.3)] bacA Bacillus licheniformis TR42415_c1_g2_i1 Q6DC93 PEF1_DANRE 4.00E-44 GO:0005509; GO:0005737 calcium ion binding; cytoplasm IPR011992; IPR018247; IPR002048; Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1) pef1 zgc:100787 Danio rerio (Zebrafish) (Brachydanio rerio) TR42415_c1_g2_i2 P12815 PDCD6_MOUSE 9.00E-51 GO:0006919; GO:0001525; GO:0060090; GO:0005509; GO:0033554; GO:0005737; GO:0031410; GO:0005789; GO:0005768; GO:0006886; GO:0032007; GO:0051898; GO:0030948; GO:0031965; GO:0045766; GO:0010595; GO:0001938; GO:0051592; GO:0036324 P25445; Q8N114 "activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; binding, bridging; calcium ion binding; cellular response to stress; cytoplasm; cytoplasmic vesicle; endoplasmic reticulum membrane; endosome; intracellular protein transport; negative regulation of TOR signaling cascade; negative regulation of protein kinase B signaling cascade; negative regulation of vascular endothelial growth factor receptor signaling pathway; nuclear membrane; positive regulation of angiogenesis; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; response to calcium ion; vascular endothelial growth factor receptor-2 signaling pathway" IPR011992; IPR018247; IPR002048; Programmed cell death protein 6 (ALG-257) (PMP41) (Probable calcium-binding protein ALG-2) Pdcd6 Alg2 Mus musculus (Mouse) TR42415_c1_g2_i3 P25070 CML24_ARATH 1.00E-10 GO:0005509; GO:0045087; GO:0048574; GO:0005886; GO:0009909; GO:0080164; GO:0009737; GO:0009646; GO:0009733; GO:0051592; GO:0009409; GO:0009408; GO:0042542; GO:0009612 "calcium ion binding; innate immune response; long-day photoperiodism, flowering; plasma membrane; regulation of flower development; regulation of nitric oxide metabolic process; response to abscisic acid stimulus; response to absence of light; response to auxin stimulus; response to calcium ion; response to cold; response to heat; response to hydrogen peroxide; response to mechanical stimulus" IPR011992; IPR018247; IPR002048; Calcium-binding protein CML24 (Calmodulin-like protein 24) (Touch-induced calmodulin-related protein 2) CML24 TCH2 At5g37770 K22F20.1 Arabidopsis thaliana (Mouse-ear cress) TR42415_c1_g2_i4 Q9C8Y1 CML23_ARATH 1.00E-09 GO:0005509; GO:0009909; GO:0080164 calcium ion binding; regulation of flower development; regulation of nitric oxide metabolic process IPR011992; IPR018247; IPR002048; Probable calcium-binding protein CML23 (Calmodulin-like protein 23) CML23 At1g66400 T27F4.15 Arabidopsis thaliana (Mouse-ear cress) TR42415_c1_g2_i5 O82659 CML20_ARATH 3.00E-08 GO:0005509; GO:0005886 calcium ion binding; plasma membrane IPR011992; IPR018247; IPR002048; Probable calcium-binding protein CML20 (Calmodulin-like protein 20) (Centrin 1) (AtCEN1) CML20 CEN1 At3g50360 F11C1.200 Arabidopsis thaliana (Mouse-ear cress) TR42415_c1_g2_i6 O75340 PDCD6_HUMAN 2.00E-47 GO:0006919; GO:0001525; GO:0097190; GO:0060090; GO:0005509; GO:0033554; GO:0031410; GO:0005783; GO:0005789; GO:0005768; GO:0006886; GO:0032007; GO:0051898; GO:0030948; GO:0031965; GO:0005634; GO:0045766; GO:0010595; GO:0001938; GO:0051592; GO:0036324 P53355; P35968; Q8WUM4; Q9NRY6; Q9H3S7; O94979 "activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; apoptotic signaling pathway; binding, bridging; calcium ion binding; cellular response to stress; cytoplasmic vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; intracellular protein transport; negative regulation of TOR signaling cascade; negative regulation of protein kinase B signaling cascade; negative regulation of vascular endothelial growth factor receptor signaling pathway; nuclear membrane; nucleus; positive regulation of angiogenesis; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; response to calcium ion; vascular endothelial growth factor receptor-2 signaling pathway" IPR011992; IPR018247; IPR002048; Programmed cell death protein 6 (Apoptosis-linked gene 2 protein) (Probable calcium-binding protein ALG-2) PDCD6 ALG2 Homo sapiens (Human) TR42416_c1_g2_i2 Q9GP32 ALF_ECHMU 2.00E-177 GO:0004332; GO:0006096 fructose-bisphosphate aldolase activity; glycolysis IPR000741; IPR013785; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. Fructose-bisphosphate aldolase (EC 4.1.2.13) FBPA Echinococcus multilocularis TR42416_c1_g2_i5 P53442 ALF_SCHMA 7.00E-130 GO:0004332; GO:0006096 fructose-bisphosphate aldolase activity; glycolysis IPR000741; IPR013785; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. Fructose-bisphosphate aldolase (EC 4.1.2.13) Schistosoma mansoni (Blood fluke) TR42417_c2_g2_i5 Q8Q0L5 COOS1_METMA 3.00E-07 GO:0051539; GO:0018492; GO:0006091; GO:0016151 "4 iron, 4 sulfur cluster binding; carbon-monoxide dehydrogenase (acceptor) activity; generation of precursor metabolites and energy; nickel cation binding" IPR016101; IPR010047; IPR004137; IPR011254; IPR016099; Carbon monoxide dehydrogenase 1 (CODH 1) (EC 1.2.99.2) cooS1 MM_0121 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR42417_c2_g4_i1 Q1MPA7 HCP_LAWIP 2.00E-62 GO:0051539; GO:0005737; GO:0050418; GO:0046872 "4 iron, 4 sulfur cluster binding; cytoplasm; hydroxylamine reductase activity; metal ion binding" IPR004137; IPR010048; IPR011254; IPR016099; IPR016100; Hydroxylamine reductase (EC 1.7.-.-) (Hybrid-cluster protein) (HCP) hcp LI1116 Lawsonia intracellularis (strain PHE/MN1-00) TR42417_c2_g4_i2 A4JPG9 HCP_BURVG 3.00E-92 GO:0051539; GO:0005737; GO:0050418; GO:0046872 "4 iron, 4 sulfur cluster binding; cytoplasm; hydroxylamine reductase activity; metal ion binding" IPR004137; IPR010048; IPR011254; IPR016099; IPR016100; Hydroxylamine reductase (EC 1.7.-.-) (Hybrid-cluster protein) (HCP) hcp Bcep1808_5223 Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808)) TR42417_c2_g4_i3 A4JPG9 HCP_BURVG 2.00E-91 GO:0051539; GO:0005737; GO:0050418; GO:0046872 "4 iron, 4 sulfur cluster binding; cytoplasm; hydroxylamine reductase activity; metal ion binding" IPR004137; IPR010048; IPR011254; IPR016099; IPR016100; Hydroxylamine reductase (EC 1.7.-.-) (Hybrid-cluster protein) (HCP) hcp Bcep1808_5223 Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808)) TR42419_c1_g4_i3 Q5TFE4 NT5D1_HUMAN 5.00E-28 GO:0016787; GO:0046872 hydrolase activity; metal ion binding IPR023214; IPR008380; 5'-nucleotidase domain-containing protein 1 (EC 3.1.3.-) NT5DC1 NT5C2L1 LP2642 Homo sapiens (Human) TR42420_c2_g3_i12 O60841 IF2P_HUMAN 0 GO:0005525; GO:0006184; GO:0003924; GO:0005829; GO:0006446; GO:0003743 O14602; P14921 GTP binding; GTP catabolic process; GTPase activity; cytosol; regulation of translational initiation; translation initiation factor activity IPR000795; IPR027417; IPR005225; IPR023115; IPR009000; IPR004161; Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2) EIF5B IF2 KIAA0741 Homo sapiens (Human) TR42420_c2_g3_i2 Q8U1R8 IF2P_PYRFU 3.00E-106 GO:0005525; GO:0006184; GO:0003924; GO:0004519; GO:0016539; GO:0005622; GO:0006314; GO:0090305; GO:0003743 GTP binding; GTP catabolic process; GTPase activity; endonuclease activity; intein-mediated protein splicing; intracellular; intron homing; nucleic acid phosphodiester bond hydrolysis; translation initiation factor activity IPR000795; IPR003586; IPR003587; IPR027434; IPR006142; IPR004042; IPR006141; IPR027417; IPR005225; IPR004544; IPR015760; IPR023115; IPR009000; IPR004161; Probable translation initiation factor IF-2 [Cleaved into: Pfu infB intein (Pfu IF2 intein)] infB PF1137 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) TR42420_c2_g3_i3 O60841 IF2P_HUMAN 0 GO:0005525; GO:0006184; GO:0003924; GO:0005829; GO:0006446; GO:0003743 O14602; P14921 GTP binding; GTP catabolic process; GTPase activity; cytosol; regulation of translational initiation; translation initiation factor activity IPR000795; IPR027417; IPR005225; IPR023115; IPR009000; IPR004161; Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2) EIF5B IF2 KIAA0741 Homo sapiens (Human) TR42420_c2_g3_i4 Q8U1R8 IF2P_PYRFU 3.00E-106 GO:0005525; GO:0006184; GO:0003924; GO:0004519; GO:0016539; GO:0005622; GO:0006314; GO:0090305; GO:0003743 GTP binding; GTP catabolic process; GTPase activity; endonuclease activity; intein-mediated protein splicing; intracellular; intron homing; nucleic acid phosphodiester bond hydrolysis; translation initiation factor activity IPR000795; IPR003586; IPR003587; IPR027434; IPR006142; IPR004042; IPR006141; IPR027417; IPR005225; IPR004544; IPR015760; IPR023115; IPR009000; IPR004161; Probable translation initiation factor IF-2 [Cleaved into: Pfu infB intein (Pfu IF2 intein)] infB PF1137 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) TR42420_c2_g3_i5 O60841 IF2P_HUMAN 0 GO:0005525; GO:0006184; GO:0003924; GO:0005829; GO:0006446; GO:0003743 O14602; P14921 GTP binding; GTP catabolic process; GTPase activity; cytosol; regulation of translational initiation; translation initiation factor activity IPR000795; IPR027417; IPR005225; IPR023115; IPR009000; IPR004161; Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2) EIF5B IF2 KIAA0741 Homo sapiens (Human) TR42420_c2_g3_i6 O60841 IF2P_HUMAN 0 GO:0005525; GO:0006184; GO:0003924; GO:0005829; GO:0006446; GO:0003743 O14602; P14921 GTP binding; GTP catabolic process; GTPase activity; cytosol; regulation of translational initiation; translation initiation factor activity IPR000795; IPR027417; IPR005225; IPR023115; IPR009000; IPR004161; Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2) EIF5B IF2 KIAA0741 Homo sapiens (Human) TR42420_c2_g3_i8 Q8U1R8 IF2P_PYRFU 2.00E-106 GO:0005525; GO:0006184; GO:0003924; GO:0004519; GO:0016539; GO:0005622; GO:0006314; GO:0090305; GO:0003743 GTP binding; GTP catabolic process; GTPase activity; endonuclease activity; intein-mediated protein splicing; intracellular; intron homing; nucleic acid phosphodiester bond hydrolysis; translation initiation factor activity IPR000795; IPR003586; IPR003587; IPR027434; IPR006142; IPR004042; IPR006141; IPR027417; IPR005225; IPR004544; IPR015760; IPR023115; IPR009000; IPR004161; Probable translation initiation factor IF-2 [Cleaved into: Pfu infB intein (Pfu IF2 intein)] infB PF1137 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) TR42420_c2_g3_i9 O60841 IF2P_HUMAN 0 GO:0005525; GO:0006184; GO:0003924; GO:0005829; GO:0006446; GO:0003743 O14602; P14921 GTP binding; GTP catabolic process; GTPase activity; cytosol; regulation of translational initiation; translation initiation factor activity IPR000795; IPR027417; IPR005225; IPR023115; IPR009000; IPR004161; Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2) EIF5B IF2 KIAA0741 Homo sapiens (Human) TR42421_c0_g2_i3 Q56R14 TRI33_XENLA 7.00E-21 GO:0003677; GO:0016874; GO:0005634; GO:0016567; GO:0006355; GO:0006351; GO:0008270 "DNA binding; ligase activity; nucleus; protein ubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 ecto Xenopus laevis (African clawed frog) TR42422_c0_g2_i2 Q3UEG6 AGT2_MOUSE 9.00E-12 GO:0047305; GO:0008453; GO:0008152; GO:0005739; GO:0030170 (R)-3-amino-2-methylpropionate-pyruvate transaminase activity; alanine-glyoxylate transaminase activity; metabolic process; mitochondrion; pyridoxal phosphate binding IPR005814; IPR015424; IPR015421; IPR015422; "Alanine--glyoxylate aminotransferase 2, mitochondrial (AGT 2) (EC 2.6.1.44) ((R)-3-amino-2-methylpropionate--pyruvate transaminase) (EC 2.6.1.40) (Beta-ALAAT II) (Beta-alanine-pyruvate aminotransferase) (D-AIBAT)" Agxt2 Mus musculus (Mouse) TR42422_c0_g2_i3 Q9BYV1 AGT2_HUMAN 0 GO:0047305; GO:0019481; GO:0008453; GO:0016223; GO:0019265; GO:0009436; GO:0005759; GO:0045429; GO:0030170; GO:0006206; GO:0046135 "(R)-3-amino-2-methylpropionate-pyruvate transaminase activity; L-alanine catabolic process, by transamination; alanine-glyoxylate transaminase activity; beta-alanine-pyruvate transaminase activity; glycine biosynthetic process, by transamination of glyoxylate; glyoxylate catabolic process; mitochondrial matrix; positive regulation of nitric oxide biosynthetic process; pyridoxal phosphate binding; pyrimidine nucleobase metabolic process; pyrimidine nucleoside catabolic process" IPR005814; IPR015424; IPR015421; IPR015422; "Alanine--glyoxylate aminotransferase 2, mitochondrial (AGT 2) (EC 2.6.1.44) ((R)-3-amino-2-methylpropionate--pyruvate transaminase) (EC 2.6.1.40) (Beta-ALAAT II) (Beta-alanine-pyruvate aminotransferase) (D-AIBAT)" AGXT2 AGT2 Homo sapiens (Human) TR42423_c2_g3_i2 Q02020 FIBB_CHICK 2.00E-27 GO:0005577; GO:0030168; GO:0051258; GO:0007165 fibrinogen complex; platelet activation; protein polymerization; signal transduction IPR014716; IPR014715; IPR002181; IPR012290; IPR020837; Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain] (Fragment) FGB Gallus gallus (Chicken) TR42423_c2_g3_i4 Q00546 TENR_CHICK 4.00E-47 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR013032; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin-R (TN-R) (Restrictin) TNR Gallus gallus (Chicken) TR42423_c2_g3_i5 Q5XK91 FBCDB_XENLA 2.00E-47 GO:0008061; GO:0016021; GO:0046872 chitin binding; integral to membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1-B fibcd1-b Xenopus laevis (African clawed frog) TR42423_c2_g3_i8 E2IYB3 FCNV1_VARKO 6.00E-26 GO:0005576 extracellular region IPR008160; IPR014716; IPR002181; Veficolin-1 (Fragment) Varanus komodoensis (Komodo dragon) TR42424_c0_g1_i1 Q8C8R3 ANK2_MOUSE 5.00E-17 GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005887; GO:0014704; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086015; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307 "M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; integral to plasma membrane; intercalated disc; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of SA node cell action potential; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Brain ankyrin) Ank2 Mus musculus (Mouse) TR42424_c0_g1_i2 Q8NFD2 ANKK1_HUMAN 9.00E-09 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR001245; IPR008271; Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) TR42424_c0_g1_i3 Q96Q27 ASB2_HUMAN 5.00E-09 GO:0031466; GO:0035556; GO:0045445; GO:0000209; GO:0042787; GO:0007165; GO:0035914; GO:0004842 Q93034; Q9UBF6 Cul5-RING ubiquitin ligase complex; intracellular signal transduction; myoblast differentiation; protein polyubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; signal transduction; skeletal muscle cell differentiation; ubiquitin-protein ligase activity IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 2 (ASB-2) ASB2 Homo sapiens (Human) TR42424_c0_g1_i4 Q502K3 ANR52_DANRE 5.00E-18 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) TR42425_c0_g2_i1 Q80T23 SYTL5_MOUSE 2.00E-93 GO:0006887; GO:0006886; GO:0016020; GO:0046872 exocytosis; intracellular protein transport; membrane; metal ion binding IPR000008; IPR010911; IPR011011; IPR013083; Synaptotagmin-like protein 5 Sytl5 Slp5 Mus musculus (Mouse) TR42427_c2_g1_i1 P17972 KCNAW_DROME 0 GO:0005251; GO:0051260; GO:0030431; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; sleep; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR015572; IPR003131; IPR028325; Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) TR42427_c2_g1_i10 P17972 KCNAW_DROME 0 GO:0005251; GO:0051260; GO:0030431; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; sleep; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR015572; IPR003131; IPR028325; Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) TR42427_c2_g1_i11 Q6DK85 KCNRG_XENTR 6.00E-07 GO:0051260 protein homooligomerization IPR000210; IPR011333; IPR003131; Putative potassium channel regulatory protein kcnrg Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42427_c2_g1_i12 Q09081 KCNA2_RABIT 2.00E-27 GO:0051260; GO:0005249; GO:0008076 protein homooligomerization; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003972; IPR003131; IPR028325; Potassium voltage-gated channel subfamily A member 2 (KC22) (Voltage-gated potassium channel subunit Kv1.2) (Fragment) KCNA2 Oryctolagus cuniculus (Rabbit) TR42427_c2_g1_i13 P17972 KCNAW_DROME 0 GO:0005251; GO:0051260; GO:0030431; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; sleep; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR015572; IPR003131; IPR028325; Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) TR42427_c2_g1_i3 P48547 KCNC1_HUMAN 4.00E-121 GO:0005251; GO:0051260; GO:0007268; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; synaptic transmission; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR005403; IPR003131; IPR028325; Potassium voltage-gated channel subfamily C member 1 (NGK2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4) KCNC1 Homo sapiens (Human) TR42427_c2_g1_i4 P48547 KCNC1_HUMAN 5.00E-127 GO:0005251; GO:0051260; GO:0007268; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; synaptic transmission; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR005403; IPR003131; IPR028325; Potassium voltage-gated channel subfamily C member 1 (NGK2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4) KCNC1 Homo sapiens (Human) TR42427_c2_g1_i5 P17972 KCNAW_DROME 0 GO:0005251; GO:0051260; GO:0030431; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; sleep; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR015572; IPR003131; IPR028325; Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) TR42427_c2_g1_i7 Q61423 KCNA4_MOUSE 2.00E-68 GO:0016020; GO:0030955; GO:0051260; GO:0005249; GO:0008076 membrane; potassium ion binding; protein homooligomerization; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003972; IPR020467; IPR012897; IPR003131; IPR028325; Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) Kcna4 Mus musculus (Mouse) TR42427_c2_g1_i9 P16388 KCNA1_MOUSE 8.00E-71 GO:0016324; GO:0005251; GO:0030425; GO:0044224; GO:0043025; GO:0051260; GO:0008076 apical plasma membrane; delayed rectifier potassium channel activity; dendrite; juxtaparanode region of axon; neuronal cell body; protein homooligomerization; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003972; IPR004048; IPR003131; IPR028325; Potassium voltage-gated channel subfamily A member 1 (MBK1) (MKI) (Voltage-gated potassium channel subunit Kv1.1) Kcna1 Mus musculus (Mouse) TR42429_c1_g1_i6 Q9Z319 CORIN_MOUSE 7.00E-12 GO:0009986; GO:0005576; GO:0007565; GO:0005887; GO:0030182; GO:0016486; GO:0006508; GO:0035813; GO:0003050; GO:0005044; GO:0004252; GO:0070008 cell surface; extracellular region; female pregnancy; integral to plasma membrane; neuron differentiation; peptide hormone processing; proteolysis; regulation of renal sodium excretion; regulation of systemic arterial blood pressure by atrial natriuretic peptide; scavenger receptor activity; serine-type endopeptidase activity; serine-type exopeptidase activity IPR020067; IPR023415; IPR002172; IPR001254; IPR018114; IPR017052; IPR001190; IPR017448; IPR009003; "Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Low density lipoprotein receptor-related protein 4) (Pro-ANP-converting enzyme) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment]" Corin Crn Lrp4 Mus musculus (Mouse) TR42430_c3_g1_i1 P07207 NOTCH_DROME 3.00E-20 GO:0005796; GO:0061382; GO:0007219; GO:0048052; GO:0007464; GO:0045466; GO:0045463; GO:0007460; GO:0007015; GO:0005912; GO:0008356; GO:0007298; GO:0005509; GO:0009986; GO:0008407; GO:0003682; GO:0042676; GO:0046667; GO:0005829; GO:0008340; GO:0046843; GO:0007391; GO:0007451; GO:0007398; GO:0035165; GO:0005788; GO:0005768; GO:0061331; GO:0035153; GO:0035214; GO:0007440; GO:0060288; GO:0030718; GO:0030708; GO:0007403; GO:0008347; GO:0035172; GO:0007157; GO:0007446; GO:0016348; GO:0048803; GO:0008587; GO:0007474; GO:0016021; GO:0035171; GO:0046331; GO:0007616; GO:0035170; GO:0007498; GO:0008045; GO:0007521; GO:0046329; GO:0045316; GO:0035157; GO:0050768; GO:0035155; GO:0000122; GO:0007400; GO:0005654; GO:0007314; GO:0030720; GO:0030713; GO:0007422; GO:1900087; GO:0045747; GO:0008284; GO:0045944; GO:0043234; GO:0045468; GO:0042686; GO:0042689; GO:0051489; GO:0040008; GO:0009608; GO:0016330; GO:0007519; GO:0035003; GO:0006351; GO:0004888; GO:0007419; GO:0048190; GO:0007473 Q24279; P10041; P28159 "Golgi lumen; Malpighian tubule tip cell differentiation; Notch signaling pathway; R1/R6 cell differentiation; R3/R4 cell fate commitment; R7 cell differentiation; R8 cell development; R8 cell fate commitment; actin filament organization; adherens junction; asymmetric cell division; border follicle cell migration; calcium ion binding; cell surface; chaeta morphogenesis; chromatin binding; compound eye cone cell fate commitment; compound eye retinal cell programmed cell death; cytosol; determination of adult lifespan; dorsal appendage formation; dorsal closure; dorsal/ventral lineage restriction, imaginal disc; ectoderm development; embryonic crystal cell differentiation; endoplasmic reticulum lumen; endosome; epithelial cell proliferation involved in Malpighian tubule morphogenesis; epithelial cell type specification, open tracheal system; eye-antennal disc development; foregut morphogenesis; formation of a compartment boundary; germ-line stem cell maintenance; germarium-derived female germ-line cyst encapsulation; glial cell fate determination; glial cell migration; hemocyte proliferation; heterophilic cell-cell adhesion; imaginal disc growth; imaginal disc-derived leg joint morphogenesis; imaginal disc-derived male genitalia morphogenesis; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein specification; integral to membrane; lamellocyte differentiation; lateral inhibition; long-term memory; lymph gland crystal cell differentiation; mesoderm development; motor neuron axon guidance; muscle cell fate determination; negative regulation of JNK cascade; negative regulation of compound eye photoreceptor development; negative regulation of fusion cell fate specification; negative regulation of neurogenesis; negative regulation of terminal cell fate specification, open tracheal system; negative regulation of transcription from RNA polymerase II promoter; neuroblast fate determination; nucleoplasm; oocyte anterior/posterior axis specification; oocyte localization involved in germarium-derived egg chamber formation; ovarian follicle cell stalk formation; peripheral nervous system development; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of Notch signaling pathway; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; protein complex; regulation of R8 cell spacing in compound eye; regulation of cardioblast cell fate specification; regulation of crystal cell differentiation; regulation of filopodium assembly; regulation of growth; response to symbiont; second mitotic wave involved in compound eye morphogenesis; skeletal muscle tissue development; subapical complex; transcription, DNA-dependent; transmembrane signaling receptor activity; ventral cord development; wing disc dorsal/ventral pattern formation; wing disc proximal/distal pattern formation" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR000800; IPR010660; IPR011656; Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) TR42430_c3_g1_i2 P46530 NOTC1_DANRE 5.00E-21 GO:0007219; GO:0005509; GO:0007368; GO:0031017; GO:0021986; GO:0055016; GO:0016021; GO:0001840; GO:0048936; GO:0048337; GO:0004872; GO:0042663; GO:0048259; GO:0006355; GO:0021523; GO:0001756; GO:0021531; GO:0006351 "Notch signaling pathway; calcium ion binding; determination of left/right symmetry; exocrine pancreas development; habenula development; hypochord development; integral to membrane; neural plate development; peripheral nervous system neuron axonogenesis; positive regulation of mesodermal cell fate specification; receptor activity; regulation of endodermal cell fate specification; regulation of receptor-mediated endocytosis; regulation of transcription, DNA-dependent; somatic motor neuron differentiation; somitogenesis; spinal cord radial glial cell differentiation; transcription, DNA-dependent" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR009030; IPR019931; IPR008297; IPR022362; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 1 notch1a notch Danio rerio (Zebrafish) (Brachydanio rerio) TR42430_c4_g1_i2 Q96KG7 MEG10_HUMAN 1.00E-26 GO:0016323; GO:0042995; GO:0034109; GO:0016021; GO:0055001; GO:0001891; GO:0043654; GO:0051147; GO:0048641; GO:0014719; GO:0014816; GO:0014841 basolateral plasma membrane; cell projection; homotypic cell-cell adhesion; integral to membrane; muscle cell development; phagocytic cup; recognition of apoptotic cell; regulation of muscle cell differentiation; regulation of skeletal muscle tissue development; satellite cell activation; satellite cell differentiation; satellite cell proliferation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) TR42430_c4_g1_i3 P13508 GLP1_CAEEL 1.00E-18 GO:0007219; GO:0005509; GO:0001708; GO:0005737; GO:0009880; GO:0012505; GO:0016021; GO:0016328; GO:0043055; GO:0043282 Notch signaling pathway; calcium ion binding; cell fate specification; cytoplasm; embryonic pattern specification; endomembrane system; integral to membrane; lateral plasma membrane; maintenance of dauer; pharyngeal muscle development IPR002110; IPR020683; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR000800; IPR010660; IPR011656; Protein glp-1 glp-1 emb-33 F02A9.6 Caenorhabditis elegans TR42430_c4_g1_i4 Q96KG7 MEG10_HUMAN 1.00E-28 GO:0016323; GO:0042995; GO:0034109; GO:0016021; GO:0055001; GO:0001891; GO:0043654; GO:0051147; GO:0048641; GO:0014719; GO:0014816; GO:0014841 basolateral plasma membrane; cell projection; homotypic cell-cell adhesion; integral to membrane; muscle cell development; phagocytic cup; recognition of apoptotic cell; regulation of muscle cell differentiation; regulation of skeletal muscle tissue development; satellite cell activation; satellite cell differentiation; satellite cell proliferation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) TR42431_c0_g2_i1 Q8C0I1 ADAS_MOUSE 4.00E-20 GO:0071949; GO:0008762; GO:0008609; GO:0008611; GO:0005739; GO:0005778 FAD binding; UDP-N-acetylmuramate dehydrogenase activity; alkylglycerone-phosphate synthase activity; ether lipid biosynthetic process; mitochondrion; peroxisomal membrane IPR025650; IPR016169; IPR016166; IPR016167; IPR016164; IPR004113; IPR006094; Glycerolipid metabolism; ether lipid biosynthesis. "Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Alkylglycerone-phosphate synthase)" Agps Mus musculus (Mouse) TR42431_c0_g2_i2 Q86WU2 LDHD_HUMAN 0 GO:0004458; GO:0008762; GO:0050660; GO:0005743; GO:0005739 D-lactate dehydrogenase (cytochrome) activity; UDP-N-acetylmuramate dehydrogenase activity; flavin adenine dinucleotide binding; mitochondrial inner membrane; mitochondrion IPR016169; IPR016166; IPR016167; IPR016164; IPR004113; IPR006094; IPR016171; "Probable D-lactate dehydrogenase, mitochondrial (DLD) (Lactate dehydrogenase D) (EC 1.1.2.4)" LDHD Homo sapiens (Human) TR42431_c0_g2_i4 Q94AX4 DLD_ARATH 4.00E-133 GO:0005524; GO:0004458; GO:0008762; GO:0050660; GO:0019154; GO:0008891; GO:0051596; GO:0005739 ATP binding; D-lactate dehydrogenase (cytochrome) activity; UDP-N-acetylmuramate dehydrogenase activity; flavin adenine dinucleotide binding; glycolate dehydrogenase activity; glycolate oxidase activity; methylglyoxal catabolic process; mitochondrion IPR016169; IPR016166; IPR016167; IPR016164; IPR004113; IPR006094; IPR016171; "D-lactate dehydrogenase [cytochrome], mitochondrial (AtD-LDH) (EC 1.1.2.4) (D-lactate ferricytochrome C oxidoreductase) (Glycolate deshydrogenase)" DLD GDH At5g06580 F15M7.11 Arabidopsis thaliana (Mouse-ear cress) TR42431_c0_g2_i7 Q86WU2 LDHD_HUMAN 0 GO:0004458; GO:0008762; GO:0050660; GO:0005743; GO:0005739 D-lactate dehydrogenase (cytochrome) activity; UDP-N-acetylmuramate dehydrogenase activity; flavin adenine dinucleotide binding; mitochondrial inner membrane; mitochondrion IPR016169; IPR016166; IPR016167; IPR016164; IPR004113; IPR006094; IPR016171; "Probable D-lactate dehydrogenase, mitochondrial (DLD) (Lactate dehydrogenase D) (EC 1.1.2.4)" LDHD Homo sapiens (Human) TR42431_c0_g4_i1 Q86WU2 LDHD_HUMAN 0 GO:0004458; GO:0008762; GO:0050660; GO:0005743; GO:0005739 D-lactate dehydrogenase (cytochrome) activity; UDP-N-acetylmuramate dehydrogenase activity; flavin adenine dinucleotide binding; mitochondrial inner membrane; mitochondrion IPR016169; IPR016166; IPR016167; IPR016164; IPR004113; IPR006094; IPR016171; "Probable D-lactate dehydrogenase, mitochondrial (DLD) (Lactate dehydrogenase D) (EC 1.1.2.4)" LDHD Homo sapiens (Human) TR42434_c0_g1_i1 F6QV99 ATAD1_BOVIN 1.00E-127 GO:0005524; GO:0016887; GO:0030054; GO:0007612; GO:0007613; GO:0005739; GO:0051967; GO:0005778; GO:0002092; GO:0045211 "ATP binding; ATPase activity; cell junction; learning; memory; mitochondrion; negative regulation of synaptic transmission, glutamatergic; peroxisomal membrane; positive regulation of receptor internalization; postsynaptic membrane" IPR003593; IPR003959; IPR003960; IPR027417; ATPase family AAA domain-containing protein 1 (EC 3.6.1.3) (Thorase) ATAD1 Bos taurus (Bovine) TR42434_c0_g1_i3 B4F6J6 ATAD1_XENTR 8.00E-94 GO:0005524; GO:0006200; GO:0016887; GO:0030054; GO:0005777; GO:0045211 ATP binding; ATP catabolic process; ATPase activity; cell junction; peroxisome; postsynaptic membrane IPR003593; IPR003959; IPR003960; IPR027417; ATPase family AAA domain-containing protein 1 (EC 3.6.1.3) atad1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42435_c0_g1_i1 Q627N3 GLC7B_CAEBR 0 GO:0051301; GO:0016568; GO:0005737; GO:0007126; GO:0046872; GO:0007067; GO:0007275; GO:0005634; GO:0004721 cell division; chromatin modification; cytoplasm; meiosis; metal ion binding; mitosis; multicellular organismal development; nucleus; phosphoprotein phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1-beta (EC 3.1.3.16) (Glc seven-like phosphatase 2) gsp-2 CBG00598 Caenorhabditis briggsae TR42435_c0_g1_i10 Q5I085 PP1B_XENTR 0 GO:0072357; GO:0007049; GO:0051301; GO:0005737; GO:0005977; GO:0046872; GO:0050115; GO:0005634; GO:0004721; GO:0030155 PTW/PP1 phosphatase complex; cell cycle; cell division; cytoplasm; glycogen metabolic process; metal ion binding; myosin-light-chain-phosphatase activity; nucleus; phosphoprotein phosphatase activity; regulation of cell adhesion IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (EC 3.1.3.16) ppp1cb TEgg049h05.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42435_c0_g1_i3 P34350 YK84_CAEEL 7.00E-39 GO:0016787 hydrolase activity IPR004843; IPR006186; Uncharacterized protein C30A5.4 C30A5.4 Caenorhabditis elegans TR42435_c0_g1_i4 P48487 PP1_BRAOL 4.00E-172 GO:0046872; GO:0004721 metal ion binding; phosphoprotein phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1 (EC 3.1.3.16) PP1 Brassica oleracea (Wild cabbage) TR42435_c0_g1_i5 Q5I085 PP1B_XENTR 0 GO:0072357; GO:0007049; GO:0051301; GO:0005737; GO:0005977; GO:0046872; GO:0050115; GO:0005634; GO:0004721; GO:0030155 PTW/PP1 phosphatase complex; cell cycle; cell division; cytoplasm; glycogen metabolic process; metal ion binding; myosin-light-chain-phosphatase activity; nucleus; phosphoprotein phosphatase activity; regulation of cell adhesion IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (EC 3.1.3.16) ppp1cb TEgg049h05.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42435_c0_g1_i7 P48483 PP13_ARATH 2.00E-168 GO:0046872; GO:0005730; GO:0006470; GO:0000164; GO:0004722 metal ion binding; nucleolus; protein dephosphorylation; protein phosphatase type 1 complex; protein serine/threonine phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1 isozyme 3 (EC 3.1.3.16) TOPP3 At1g64040 F22C12.20 Arabidopsis thaliana (Mouse-ear cress) TR42435_c0_g1_i8 Q3SWT6 PPE1_RAT 7.00E-37 GO:0005509; GO:0050906; GO:0005506; GO:0030145; GO:0004721 calcium ion binding; detection of stimulus involved in sensory perception; iron ion binding; manganese ion binding; phosphoprotein phosphatase activity IPR011992; IPR018247; IPR002048; IPR000048; IPR004843; IPR013235; IPR012008; IPR006186; Serine/threonine-protein phosphatase with EF-hands 1 (PPEF-1) (EC 3.1.3.16) Ppef1 Rattus norvegicus (Rat) TR42437_c1_g1_i4 Q14517 FAT1_HUMAN 3.00E-17 GO:0007015; GO:0009653; GO:0005509; GO:0016477; GO:0016337; GO:0005911; GO:0007267; GO:0007163; GO:0030175; GO:0007156; GO:0005887; GO:0030027; GO:0005634; GO:0048471 Q8N8S7; Q9NSC5; Q99JP6 actin filament organization; anatomical structure morphogenesis; calcium ion binding; cell migration; cell-cell adhesion; cell-cell junction; cell-cell signaling; establishment or maintenance of cell polarity; filopodium; homophilic cell adhesion; integral to plasma membrane; lamellipodium; nucleus; perinuclear region of cytoplasm IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) TR42437_c1_g1_i6 Q6V0I7 FAT4_HUMAN 2.00E-14 GO:0005509; GO:0007156; GO:0016021; GO:0005886 Q9H2K2 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) TR42437_c1_g1_i7 Q14517 FAT1_HUMAN 4.00E-16 GO:0007015; GO:0009653; GO:0005509; GO:0016477; GO:0016337; GO:0005911; GO:0007267; GO:0007163; GO:0030175; GO:0007156; GO:0005887; GO:0030027; GO:0005634; GO:0048471 Q8N8S7; Q9NSC5; Q99JP6 actin filament organization; anatomical structure morphogenesis; calcium ion binding; cell migration; cell-cell adhesion; cell-cell junction; cell-cell signaling; establishment or maintenance of cell polarity; filopodium; homophilic cell adhesion; integral to plasma membrane; lamellipodium; nucleus; perinuclear region of cytoplasm IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) TR42438_c2_g1_i1 O57579 AMPN_CHICK 0 GO:0004177; GO:0016021; GO:0008237; GO:0005886; GO:0006508; GO:0008270 aminopeptidase activity; integral to membrane; metallopeptidase activity; plasma membrane; proteolysis; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (EC 3.4.11.2) (Aminopeptidase Ey) (EC 3.4.11.20) ANPEP APDE Gallus gallus (Chicken) TR42438_c2_g1_i5 P79143 AMPN_CANFA 4.00E-24 GO:0004177; GO:0001525; GO:0030154; GO:0005793; GO:0009897; GO:0008237; GO:0019048; GO:0006508; GO:0009615; GO:0001618 aminopeptidase activity; angiogenesis; cell differentiation; endoplasmic reticulum-Golgi intermediate compartment; external side of plasma membrane; metallopeptidase activity; modulation by virus of host morphology or physiology; proteolysis; response to virus; virus receptor activity IPR024571; IPR001930; Aminopeptidase N (AP-N) (cAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) (Fragment) ANPEP Canis familiaris (Dog) (Canis lupus familiaris) TR42439_c1_g1_i3 Q6TFL4 KLH24_HUMAN 2.00E-73 GO:0030424; GO:0005737; GO:0043204 axon; cytoplasm; perikaryon IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) KLHL24 DRE1 Homo sapiens (Human) TR42441_c2_g2_i1 Q32NR4 TTC29_XENLA 5.00E-63 IPR013026; IPR011990; IPR024819; IPR019734; Tetratricopeptide repeat protein 29 (TPR repeat protein 29) ttc29 Xenopus laevis (African clawed frog) TR42441_c2_g2_i2 Q80XJ3 TTC28_MOUSE 4.00E-07 GO:0051301; GO:0005813; GO:0005737; GO:0030496; GO:0007067; GO:1990023; GO:0097431; GO:0007346 cell division; centrosome; cytoplasm; midbody; mitosis; mitotic spindle midzone; mitotic spindle pole; regulation of mitotic cell cycle IPR024983; IPR013026; IPR011990; IPR001440; IPR013105; IPR019734; Tetratricopeptide repeat protein 28 (TPR repeat protein 28) Ttc28 Kiaa1043 Tprbk Mus musculus (Mouse) TR42441_c2_g2_i3 Q32NR4 TTC29_XENLA 4.00E-63 IPR013026; IPR011990; IPR024819; IPR019734; Tetratricopeptide repeat protein 29 (TPR repeat protein 29) ttc29 Xenopus laevis (African clawed frog) TR42441_c2_g2_i5 P81274 GPSM2_HUMAN 4.00E-08 GO:0007186; GO:0005092; GO:0045177; GO:0005938; GO:0005737; GO:0000132; GO:0060487; GO:0005634; GO:0008277 Itself; P63096; Q14980 G-protein coupled receptor signaling pathway; GDP-dissociation inhibitor activity; apical part of cell; cell cortex; cytoplasm; establishment of mitotic spindle orientation; lung epithelial cell differentiation; nucleus; regulation of G-protein coupled receptor protein signaling pathway IPR024807; IPR003109; IPR013026; IPR011990; IPR001440; IPR019734; G-protein-signaling modulator 2 (Mosaic protein LGN) GPSM2 LGN Homo sapiens (Human) TR42441_c2_g4_i1 A7HHN1 URE1_ANADF 0 GO:0005737; GO:0016151; GO:0043419; GO:0009039 cytoplasm; nickel cation binding; urea catabolic process; urease activity IPR006680; IPR011059; IPR011612; IPR005848; IPR017951; IPR017950; Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. Urease subunit alpha (EC 3.5.1.5) (Urea amidohydrolase subunit alpha) ureC Anae109_4049 Anaeromyxobacter sp. (strain Fw109-5) TR42441_c2_g4_i2 P07374 UREA_CANEN 0 GO:0016151; GO:0043419; GO:0009039 nickel cation binding; urea catabolic process; urease activity IPR006680; IPR011059; IPR008221; IPR011612; IPR005848; IPR017951; IPR017950; IPR002019; IPR002026; Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. Urease (EC 3.5.1.5) (Urea amidohydrolase) Canavalia ensiformis (Jack bean) (Dolichos ensiformis) TR42441_c2_g4_i3 Q826S1 URE3_STRAW 5.00E-32 GO:0005737; GO:0016151; GO:0043419; GO:0009039 cytoplasm; nickel cation binding; urea catabolic process; urease activity IPR002026; IPR012010; Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. Urease subunit gamma (EC 3.5.1.5) (Urea amidohydrolase subunit gamma) ureA SAV_7104 Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680) TR42443_c3_g4_i10 Q9NUK0 MBNL3_HUMAN 5.00E-71 GO:0005794; GO:0008380; GO:0006397; GO:0046872; GO:0007275; GO:0045662; GO:0005634; GO:0043484 Golgi apparatus; RNA splicing; mRNA processing; metal ion binding; multicellular organismal development; negative regulation of myoblast differentiation; nucleus; regulation of RNA splicing IPR000571; Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein HCHCR) MBNL3 CHCR MBLX39 MBXL Homo sapiens (Human) TR42443_c3_g4_i2 O16011 MBL_DROME 1.00E-53 GO:0003677; GO:0006915; GO:0009790; GO:0007476; GO:0046872; GO:0046716; GO:0007517; GO:0005634; GO:0048471; GO:0007422; GO:0000381; GO:0045924; GO:0042052; GO:0007525; GO:0007601 "DNA binding; apoptotic process; embryo development; imaginal disc-derived wing morphogenesis; metal ion binding; muscle cell cellular homeostasis; muscle organ development; nucleus; perinuclear region of cytoplasm; peripheral nervous system development; regulation of alternative mRNA splicing, via spliceosome; regulation of female receptivity; rhabdomere development; somatic muscle development; visual perception" IPR000571; Protein muscleblind (Protein mindmelt) mbl mm CG33197 Drosophila melanogaster (Fruit fly) TR42443_c3_g4_i6 Q9NUK0 MBNL3_HUMAN 7.00E-71 GO:0005794; GO:0008380; GO:0006397; GO:0046872; GO:0007275; GO:0045662; GO:0005634; GO:0043484 Golgi apparatus; RNA splicing; mRNA processing; metal ion binding; multicellular organismal development; negative regulation of myoblast differentiation; nucleus; regulation of RNA splicing IPR000571; Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein HCHCR) MBNL3 CHCR MBLX39 MBXL Homo sapiens (Human) TR42444_c3_g2_i1 Q3UFQ8 LR16B_MOUSE 2.00E-88 GO:0005737 cytoplasm Leucine-rich repeat-containing protein 16B Lrrc16b Mus musculus (Mouse) TR42444_c3_g2_i2 Q6EDY6 LR16A_MOUSE 2.00E-114 GO:0016477; GO:0005737; GO:0030027; GO:0030032; GO:0005634; GO:0031529; GO:0046415 cell migration; cytoplasm; lamellipodium; lamellipodium assembly; nucleus; ruffle organization; urate metabolic process Leucine-rich repeat-containing protein 16A (CARMIL homolog) Lrrc16a Carmil Lrrc16 Mus musculus (Mouse) TR42444_c5_g1_i1 Q7L622 G2E3_HUMAN 2.00E-46 GO:0005794; GO:0006915; GO:0001824; GO:0043066; GO:0005730; GO:0000209; GO:0004842; GO:0008270 Golgi apparatus; apoptotic process; blastocyst development; negative regulation of apoptotic process; nucleolus; protein polyubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR000569; IPR019786; IPR011011; IPR001965; IPR001841; IPR013083; Protein modification; protein ubiquitination. G2/M phase-specific E3 ubiquitin-protein ligase (EC 6.3.2.-) G2E3 KIAA1333 Homo sapiens (Human) TR42448_c0_g1_i10 P26443 DHE3_MOUSE 0 GO:0005524; GO:0005525; GO:0004352; GO:0004353; GO:0006541; GO:0007616; GO:0005743; GO:0005759; GO:0032024; GO:0010044; GO:0072350 ATP binding; GTP binding; glutamate dehydrogenase (NAD+) activity; glutamate dehydrogenase [NAD(P)+] activity; glutamine metabolic process; long-term memory; mitochondrial inner membrane; mitochondrial matrix; positive regulation of insulin secretion; response to aluminum ion; tricarboxylic acid metabolic process IPR006095; IPR006096; IPR006097; IPR016040; "Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)" Glud1 Glud Mus musculus (Mouse) TR42448_c0_g1_i11 P26443 DHE3_MOUSE 0 GO:0005524; GO:0005525; GO:0004352; GO:0004353; GO:0006541; GO:0007616; GO:0005743; GO:0005759; GO:0032024; GO:0010044; GO:0072350 ATP binding; GTP binding; glutamate dehydrogenase (NAD+) activity; glutamate dehydrogenase [NAD(P)+] activity; glutamine metabolic process; long-term memory; mitochondrial inner membrane; mitochondrial matrix; positive regulation of insulin secretion; response to aluminum ion; tricarboxylic acid metabolic process IPR006095; IPR006096; IPR006097; IPR016040; "Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)" Glud1 Glud Mus musculus (Mouse) TR42448_c0_g1_i3 P00367 DHE3_HUMAN 0 GO:0043531; GO:0005524; GO:0005525; GO:0070403; GO:0034641; GO:0006537; GO:0006538; GO:0004352; GO:0004353; GO:0006541; GO:0042802; GO:0070728; GO:0005759; GO:0032024; GO:0072350 ADP binding; ATP binding; GTP binding; NAD+ binding; cellular nitrogen compound metabolic process; glutamate biosynthetic process; glutamate catabolic process; glutamate dehydrogenase (NAD+) activity; glutamate dehydrogenase [NAD(P)+] activity; glutamine metabolic process; identical protein binding; leucine binding; mitochondrial matrix; positive regulation of insulin secretion; tricarboxylic acid metabolic process IPR006095; IPR006096; IPR006097; IPR016040; "Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)" GLUD1 GLUD Homo sapiens (Human) TR42448_c0_g1_i6 P26443 DHE3_MOUSE 0 GO:0005524; GO:0005525; GO:0004352; GO:0004353; GO:0006541; GO:0007616; GO:0005743; GO:0005759; GO:0032024; GO:0010044; GO:0072350 ATP binding; GTP binding; glutamate dehydrogenase (NAD+) activity; glutamate dehydrogenase [NAD(P)+] activity; glutamine metabolic process; long-term memory; mitochondrial inner membrane; mitochondrial matrix; positive regulation of insulin secretion; response to aluminum ion; tricarboxylic acid metabolic process IPR006095; IPR006096; IPR006097; IPR016040; "Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)" Glud1 Glud Mus musculus (Mouse) TR42448_c0_g1_i8 P96110 DHE3_THEMA 7.00E-79 GO:0006520; GO:0004353 cellular amino acid metabolic process; glutamate dehydrogenase [NAD(P)+] activity IPR006095; IPR006096; IPR006097; IPR014362; IPR016040; Glutamate dehydrogenase (GDH) (EC 1.4.1.3) gdhA gdh TM_1015 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR42449_c0_g1_i2 Q923Y7 TAAR4_RAT 2.00E-06 GO:0007610; GO:0016021; GO:0005886; GO:0001594 behavior; integral to membrane; plasma membrane; trace-amine receptor activity IPR000276; IPR017452; IPR009132; Trace amine-associated receptor 4 (TaR-4) (Trace amine receptor 4) (2-phenylethylamine receptor) (Trace amine receptor 2) (TaR-2) Taar4 Ta2 Tar2 Trar2 Rattus norvegicus (Rat) TR42449_c0_g1_i3 Q63447 NPY4R_RAT 9.00E-07 GO:0016021; GO:0001602; GO:0001601; GO:0042277; GO:0005886 integral to membrane; pancreatic polypeptide receptor activity; peptide YY receptor activity; peptide binding; plasma membrane IPR000276; IPR017452; IPR001933; IPR000611; Neuropeptide Y receptor type 4 (NPY4-R) (Pancreatic polypeptide receptor 1) (PP1) Npy4r Ppyr1 Rattus norvegicus (Rat) TR42449_c1_g3_i1 Q9Y2H1 ST38L_HUMAN 0 GO:0005524; GO:0015629; GO:0005737; GO:0007243; GO:0000287; GO:0005634; GO:0005886; GO:0004674; GO:0051128 ATP binding; actin cytoskeleton; cytoplasm; intracellular protein kinase cascade; magnesium ion binding; nucleus; plasma membrane; protein serine/threonine kinase activity; regulation of cellular component organization IPR000961; IPR011009; IPR017892; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2) STK38L KIAA0965 NDR2 Homo sapiens (Human) TR4245_c0_g1_i1 Q8BND5 QSOX1_MOUSE 3.00E-25 GO:0045454; GO:0005783; GO:0005615; GO:0016971; GO:0030173; GO:0003756 cell redox homeostasis; endoplasmic reticulum; extracellular space; flavin-linked sulfhydryl oxidase activity; integral to Golgi membrane; protein disulfide isomerase activity IPR017905; IPR012336; IPR013766; Sulfhydryl oxidase 1 (mSOx) (EC 1.8.3.2) (Quiescin Q6) (Skin sulfhydryl oxidase) Qsox1 Qscn6 Sox Mus musculus (Mouse) TR42450_c1_g3_i2 Q91VT8 CD034_MOUSE 1.00E-17 GO:0016021 integral to membrane IPR020309; Small integral membrane protein 14 Smim14 Mus musculus (Mouse) TR42451_c0_g1_i1 Q16537 2A5E_HUMAN 0 GO:0005737; GO:0043231; GO:0000159; GO:0008601; GO:0007165 O96017; Q86YF9; P30153; P30154; Q9H0H5 cytoplasm; intracellular membrane-bounded organelle; protein phosphatase type 2A complex; protein phosphatase type 2A regulator activity; signal transduction IPR016024; IPR002554; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon) PPP2R5E Homo sapiens (Human) TR42454_c0_g2_i1 Q90XF2 KPCI_DANRE 5.00E-14 GO:0005524; GO:0034334; GO:0045217; GO:0005829; GO:0007502; GO:0048546; GO:0021744; GO:0035050; GO:0000132; GO:0016332; GO:0035556; GO:0031226; GO:0045199; GO:0008078; GO:0001738; GO:0001841; GO:0007405; GO:0007097; GO:0005634; GO:0042476; GO:0005543; GO:0004697; GO:0004674; GO:0060042; GO:0008270; GO:0005915 ATP binding; adherens junction maintenance; cell-cell junction maintenance; cytosol; digestive tract mesoderm development; digestive tract morphogenesis; dorsal motor nucleus of vagus nerve development; embryonic heart tube development; establishment of mitotic spindle orientation; establishment or maintenance of polarity of embryonic epithelium; intracellular signal transduction; intrinsic to plasma membrane; maintenance of epithelial cell apical/basal polarity; mesodermal cell migration; morphogenesis of a polarized epithelium; neural tube formation; neuroblast proliferation; nuclear migration; nucleus; odontogenesis; phospholipid binding; protein kinase C activity; protein serine/threonine kinase activity; retina morphogenesis in camera-type eye; zinc ion binding; zonula adherens IPR000961; IPR020454; IPR011009; IPR000270; IPR012233; IPR017892; IPR002219; IPR000719; IPR017441; IPR002290; IPR008271; Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (Heart and soul protein) (nPKC-iota) prkci hal Danio rerio (Zebrafish) (Brachydanio rerio) TR42454_c0_g2_i3 Q90XF2 KPCI_DANRE 2.00E-14 GO:0005524; GO:0034334; GO:0045217; GO:0005829; GO:0007502; GO:0048546; GO:0021744; GO:0035050; GO:0000132; GO:0016332; GO:0035556; GO:0031226; GO:0045199; GO:0008078; GO:0001738; GO:0001841; GO:0007405; GO:0007097; GO:0005634; GO:0042476; GO:0005543; GO:0004697; GO:0004674; GO:0060042; GO:0008270; GO:0005915 ATP binding; adherens junction maintenance; cell-cell junction maintenance; cytosol; digestive tract mesoderm development; digestive tract morphogenesis; dorsal motor nucleus of vagus nerve development; embryonic heart tube development; establishment of mitotic spindle orientation; establishment or maintenance of polarity of embryonic epithelium; intracellular signal transduction; intrinsic to plasma membrane; maintenance of epithelial cell apical/basal polarity; mesodermal cell migration; morphogenesis of a polarized epithelium; neural tube formation; neuroblast proliferation; nuclear migration; nucleus; odontogenesis; phospholipid binding; protein kinase C activity; protein serine/threonine kinase activity; retina morphogenesis in camera-type eye; zinc ion binding; zonula adherens IPR000961; IPR020454; IPR011009; IPR000270; IPR012233; IPR017892; IPR002219; IPR000719; IPR017441; IPR002290; IPR008271; Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (Heart and soul protein) (nPKC-iota) prkci hal Danio rerio (Zebrafish) (Brachydanio rerio) TR42454_c0_g2_i5 O34507 PRKC_BACSU 1.00E-09 GO:0005524; GO:0071224; GO:0016021; GO:0008658; GO:0042834; GO:0005886; GO:0004674; GO:0007165; GO:0009847 ATP binding; cellular response to peptidoglycan; integral to membrane; penicillin binding; peptidoglycan binding; plasma membrane; protein serine/threonine kinase activity; signal transduction; spore germination IPR011009; IPR005543; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase PrkC (Ser/Thr-protein kinase PrkC) (EC 2.7.11.1) prkC yloP BSU15770 Bacillus subtilis (strain 168) TR42455_c1_g2_i1 Q9CY57 FOP_MOUSE 2.00E-12 GO:0003723; GO:0005730; GO:0005654; GO:0006355; GO:0006351 Q9JIF0; Q8CIG8 "RNA binding; nucleolus; nucleoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025715; Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) Chtop Fop MNCb-1706 Mus musculus (Mouse) TR42455_c1_g2_i10 Q9CY57 FOP_MOUSE 7.00E-13 GO:0003723; GO:0005730; GO:0005654; GO:0006355; GO:0006351 Q9JIF0; Q8CIG8 "RNA binding; nucleolus; nucleoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025715; Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) Chtop Fop MNCb-1706 Mus musculus (Mouse) TR42455_c1_g2_i12 Q9Y3Y2 CHTOP_HUMAN 9.00E-11 GO:0003723; GO:0005654; GO:0005634; GO:0006355; GO:0006351 Q99873 "RNA binding; nucleoplasm; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025715; Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) CHTOP C1orf77 FOP HT031 PP7704 Homo sapiens (Human) TR42455_c1_g2_i14 Q9CY57 FOP_MOUSE 2.00E-12 GO:0003723; GO:0005730; GO:0005654; GO:0006355; GO:0006351 Q9JIF0; Q8CIG8 "RNA binding; nucleolus; nucleoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025715; Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) Chtop Fop MNCb-1706 Mus musculus (Mouse) TR42455_c1_g2_i15 Q9Y3Y2 CHTOP_HUMAN 3.00E-11 GO:0003723; GO:0005654; GO:0005634; GO:0006355; GO:0006351 Q99873 "RNA binding; nucleoplasm; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025715; Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) CHTOP C1orf77 FOP HT031 PP7704 Homo sapiens (Human) TR42455_c1_g2_i2 Q9Y3Y2 CHTOP_HUMAN 9.00E-11 GO:0003723; GO:0005654; GO:0005634; GO:0006355; GO:0006351 Q99873 "RNA binding; nucleoplasm; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025715; Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) CHTOP C1orf77 FOP HT031 PP7704 Homo sapiens (Human) TR42455_c1_g2_i3 Q9Y3Y2 CHTOP_HUMAN 1.00E-11 GO:0003723; GO:0005654; GO:0005634; GO:0006355; GO:0006351 Q99873 "RNA binding; nucleoplasm; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025715; Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) CHTOP C1orf77 FOP HT031 PP7704 Homo sapiens (Human) TR42455_c1_g2_i4 Q9CY57 FOP_MOUSE 2.00E-12 GO:0003723; GO:0005730; GO:0005654; GO:0006355; GO:0006351 Q9JIF0; Q8CIG8 "RNA binding; nucleolus; nucleoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025715; Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) Chtop Fop MNCb-1706 Mus musculus (Mouse) TR42456_c3_g2_i1 P70345 B2CL2_MOUSE 6.00E-28 GO:0060011; GO:0005829; GO:0097192; GO:0031966; GO:0043066 Sertoli cell proliferation; cytosol; extrinsic apoptotic signaling pathway in absence of ligand; mitochondrial membrane; negative regulation of apoptotic process IPR013280; IPR002475; IPR020717; IPR020726; IPR003093; IPR020731; IPR026298; Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W) (c98) Bcl2l2 Bclw Kiaa0271 Mus musculus (Mouse) TR42456_c3_g2_i3 Q07817 B2CL1_HUMAN 1.00E-32 GO:0097136; GO:0008283; GO:0060154; GO:0071312; GO:0071230; GO:0071480; GO:0005813; GO:0000910; GO:0005829; GO:0009566; GO:0007281; GO:0040007; GO:0001701; GO:0045087; GO:0016021; GO:0097193; GO:0008584; GO:0005741; GO:0007093; GO:2000811; GO:0010507; GO:0090005; GO:1900118; GO:2001240; GO:2001243; GO:1902230; GO:0043524; GO:0090201; GO:0031965; GO:0035872; GO:0001541; GO:0043065; GO:0008284; GO:2001244; GO:0046902; GO:0051881; GO:0001836; GO:0046898; GO:0034097; GO:0007283; GO:0019050 Itself; Q92934; Q61337; Q16611; Q07812; Q9BXH1; Q99ML1; O43521; O43521-1; Q14457; P55957; Q13323; P30429; P10909-4; O00198; Q9C000; O15304; O15304-1; Q9H2V7; P04637; P02340; Q13625; Q86Y07-1 "Bcl-2 family protein complex; cell proliferation; cellular process regulating host cell cycle in response to virus; cellular response to alkaloid; cellular response to amino acid stimulus; cellular response to gamma radiation; centrosome; cytokinesis; cytosol; fertilization; germ cell development; growth; in utero embryonic development; innate immune response; integral to membrane; intrinsic apoptotic signaling pathway; male gonad development; mitochondrial outer membrane; mitotic cell cycle checkpoint; negative regulation of anoikis; negative regulation of autophagy; negative regulation of establishment of protein localization to plasma membrane; negative regulation of execution phase of apoptosis; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of neuron apoptotic process; negative regulation of release of cytochrome c from mitochondria; nuclear membrane; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; ovarian follicle development; positive regulation of apoptotic process; positive regulation of cell proliferation; positive regulation of intrinsic apoptotic signaling pathway; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; release of cytochrome c from mitochondria; response to cycloheximide; response to cytokine stimulus; spermatogenesis; suppression by virus of host apoptotic process" IPR013279; IPR002475; IPR004725; IPR020717; IPR020726; IPR020728; IPR003093; IPR020731; IPR026298; Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) BCL2L1 BCL2L BCLX Homo sapiens (Human) TR42458_c2_g1_i1 Q5TZE1 BTB6B_DANRE 2.00E-38 GO:0030154; GO:0000932; GO:0007399 cell differentiation; cytoplasmic mRNA processing body; nervous system development IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6-B btbd6b btbd6 si:dkey-11b8.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR42458_c2_g1_i10 Q9BX70 BTBD2_HUMAN 2.00E-42 GO:0000932 Q7L5N1; P04637 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) TR42458_c2_g1_i11 Q9LQ95 Y1164_ARATH 7.00E-07 GO:0016567 protein ubiquitination IPR000210; IPR011333; IPR013069; Protein modification; protein ubiquitination. BTB/POZ domain-containing protein At1g01640 At1g01640 T1N6.2 Arabidopsis thaliana (Mouse-ear cress) TR42458_c2_g1_i12 Q70JS2 KELC_ANOST 1.00E-14 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR006652; Ring canal kelch homolog (Kelch-like protein 1) [Cleaved into: Kelch short protein] kel Anopheles stephensi (Indo-Pakistan malaria mosquito) TR42458_c2_g1_i2 Q9SRV1 BPM4_ARATH 7.00E-12 GO:0071472; GO:0042631; GO:0005829; GO:0016567 cellular response to salt stress; cellular response to water deprivation; cytosol; protein ubiquitination IPR000210; IPR011333; IPR013069; IPR002083; IPR008974; Protein modification; protein ubiquitination. BTB/POZ and MATH domain-containing protein 4 (Protein BTB-POZ AND MATH DOMAIN 4) (AtBPM4) BPM4 At3g03740 F20H23.23 Arabidopsis thaliana (Mouse-ear cress) TR42458_c2_g1_i4 Q96KE9 BTBD6_HUMAN 5.00E-40 GO:0000932 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6 (Lens BTB domain protein) BTBD6 BDPL Homo sapiens (Human) TR42458_c2_g1_i5 Q9BX70 BTBD2_HUMAN 1.00E-40 GO:0000932 Q7L5N1; P04637 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) TR42458_c2_g1_i9 Q14145 KEAP1_HUMAN 2.00E-06 GO:0031463; GO:0071353; GO:0005813; GO:0005737; GO:0005783; GO:0001701; GO:0030496; GO:0005634; GO:0010499; GO:0016567; GO:0045604; GO:0006355; GO:0006351 Q9NY33; O14920; O88351; P15314; Q16236; Q04206; Q13501; Q64337; Q9Y3Q8 "Cul3-RING ubiquitin ligase complex; cellular response to interleukin-4; centrosome; cytoplasm; endoplasmic reticulum; in utero embryonic development; midbody; nucleus; proteasomal ubiquitin-independent protein catabolic process; protein ubiquitination; regulation of epidermal cell differentiation; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19) KEAP1 INRF2 KIAA0132 KLHL19 Homo sapiens (Human) TR42460_c2_g2_i3 P00432 CATA_BOVIN 0 GO:0050661; GO:0009650; GO:0009060; GO:0004046; GO:0004096; GO:0008203; GO:0020037; GO:0020027; GO:0042744; GO:0046872; GO:0005739; GO:0032088; GO:0043066; GO:0005778; GO:0051092; GO:0051781; GO:0014068; GO:0051289; GO:0006641 NADP binding; UV protection; aerobic respiration; aminoacylase activity; catalase activity; cholesterol metabolic process; heme binding; hemoglobin metabolic process; hydrogen peroxide catabolic process; metal ion binding; mitochondrion; negative regulation of NF-kappaB transcription factor activity; negative regulation of apoptotic process; peroxisomal membrane; positive regulation of NF-kappaB transcription factor activity; positive regulation of cell division; positive regulation of phosphatidylinositol 3-kinase cascade; protein homotetramerization; triglyceride metabolic process IPR018028; IPR020835; IPR024708; IPR024711; IPR011614; IPR002226; IPR010582; Catalase (EC 1.11.1.6) CAT Bos taurus (Bovine) TR42460_c2_g2_i5 P00432 CATA_BOVIN 0 GO:0050661; GO:0009650; GO:0009060; GO:0004046; GO:0004096; GO:0008203; GO:0020037; GO:0020027; GO:0042744; GO:0046872; GO:0005739; GO:0032088; GO:0043066; GO:0005778; GO:0051092; GO:0051781; GO:0014068; GO:0051289; GO:0006641 NADP binding; UV protection; aerobic respiration; aminoacylase activity; catalase activity; cholesterol metabolic process; heme binding; hemoglobin metabolic process; hydrogen peroxide catabolic process; metal ion binding; mitochondrion; negative regulation of NF-kappaB transcription factor activity; negative regulation of apoptotic process; peroxisomal membrane; positive regulation of NF-kappaB transcription factor activity; positive regulation of cell division; positive regulation of phosphatidylinositol 3-kinase cascade; protein homotetramerization; triglyceride metabolic process IPR018028; IPR020835; IPR024708; IPR024711; IPR011614; IPR002226; IPR010582; Catalase (EC 1.11.1.6) CAT Bos taurus (Bovine) TR42461_c6_g6_i1 A2AV25 FBCD1_MOUSE 8.00E-54 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 Fibcd1 Mus musculus (Mouse) TR42461_c6_g6_i6 Q14314 FGL2_HUMAN 6.00E-39 GO:0005577 fibrinogen complex IPR014716; IPR014715; IPR002181; IPR020837; Fibroleukin (Fibrinogen-like protein 2) (pT49) FGL2 Homo sapiens (Human) TR42462_c2_g1_i1 Q9Z0L8 GGH_MOUSE 2.00E-80 GO:0005829; GO:0005615; GO:0034722; GO:0006541; GO:0005764; GO:0042470; GO:0042493; GO:0045471; GO:0032868; GO:0010043 cytosol; extracellular space; gamma-glutamyl-peptidase activity; glutamine metabolic process; lysosome; melanosome; response to drug; response to ethanol; response to insulin stimulus; response to zinc ion IPR015527; IPR011697; Gamma-glutamyl hydrolase (EC 3.4.19.9) (Conjugase) (FGPH) (Folylpolyglutamate hydrolase) (GH) (Gamma-Glu-x carboxypeptidase) Ggh Mus musculus (Mouse) TR42464_c3_g4_i1 Q03168 ASPP_AEDAE 9.00E-162 GO:0004190; GO:0005764; GO:0006508 aspartic-type endopeptidase activity; lysosome; proteolysis IPR001461; IPR001969; IPR012848; IPR021109; Lysosomal aspartic protease (EC 3.4.23.-) AAEL006169 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR42464_c3_g4_i4 Q766C3 NEP1_NEPGR 9.00E-07 GO:0004190; GO:0005576; GO:0006508 aspartic-type endopeptidase activity; extracellular region; proteolysis IPR001461; IPR001969; IPR021109; Aspartic proteinase nepenthesin-1 (EC 3.4.23.12) (Nepenthesin-I) nep1 Nepenthes gracilis (Slender pitcher plant) TR42464_c3_g4_i6 Q03168 ASPP_AEDAE 1.00E-167 GO:0004190; GO:0005764; GO:0006508 aspartic-type endopeptidase activity; lysosome; proteolysis IPR001461; IPR001969; IPR012848; IPR021109; Lysosomal aspartic protease (EC 3.4.23.-) AAEL006169 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR42464_c3_g4_i8 O93428 CATD_CHIHA 8.00E-156 GO:0004190; GO:0005764; GO:0006508 aspartic-type endopeptidase activity; lysosome; proteolysis IPR001461; IPR001969; IPR012848; IPR021109; Cathepsin D (EC 3.4.23.5) ctsd Chionodraco hamatus (Antarctic teleost icefish) (Chaenichthys rhinoceratus hamatus) TR42465_c1_g2_i1 Q8CHR6 DPYD_MOUSE 0 GO:0051539; GO:0006222; GO:0019483; GO:0005829; GO:0004158; GO:0017113; GO:0046872; GO:0000166; GO:0006214; GO:0006212 "4 iron, 4 sulfur cluster binding; UMP biosynthetic process; beta-alanine biosynthetic process; cytosol; dihydroorotate oxidase activity; dihydropyrimidine dehydrogenase (NADP+) activity; metal ion binding; nucleotide binding; thymidine catabolic process; uracil catabolic process" IPR017896; IPR017900; IPR013785; IPR005720; IPR012135; IPR028261; IPR009051; Amino-acid biosynthesis; beta-alanine biosynthesis. Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) Dpyd Mus musculus (Mouse) TR42465_c1_g2_i2 Q8TXU6 PYRDB_METKA 9.00E-07 GO:0044205; GO:0006207; GO:0005737; GO:0004158; GO:0004589 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; cytoplasm; dihydroorotate oxidase activity; orotate reductase (NADH) activity IPR013785; IPR005720; IPR024920; IPR012135; IPR001295; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD(+) route): step 1/1. "Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit (DHOD B) (DHODase B) (DHOdehase B) (EC 1.3.1.14) (Dihydroorotate oxidase B) (Orotate reductase (NADH))" pyrD MK0563 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) TR42465_c1_g3_i1 C0QYH6 PYRDB_BRAHW 1.00E-06 GO:0044205; GO:0006207; GO:0005737; GO:0004158; GO:0004589 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; cytoplasm; dihydroorotate oxidase activity; orotate reductase (NADH) activity IPR013785; IPR005720; IPR024920; IPR012135; IPR001295; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD(+) route): step 1/1. "Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit (DHOD B) (DHODase B) (DHOdehase B) (EC 1.3.1.14) (Dihydroorotate oxidase B) (Orotate reductase (NADH))" pyrD BHWA1_02606 Brachyspira hyodysenteriae (strain ATCC 49526 / WA1) TR42465_c1_g3_i2 Q57563 FER2_METJA 2.00E-06 GO:0051539; GO:0046872; GO:0055114 "4 iron, 4 sulfur cluster binding; metal ion binding; oxidation-reduction process" IPR001450; IPR017896; IPR017900; IPR018449; Uncharacterized ferredoxin MJ0099 MJ0099 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR42465_c1_g3_i3 Q8ZNL7 PREA_SALTY 2.00E-11 GO:0051539; GO:0003954; GO:0006222; GO:0005737; GO:0004158; GO:0004159; GO:0046872; GO:0006208 "4 iron, 4 sulfur cluster binding; NADH dehydrogenase activity; UMP biosynthetic process; cytoplasm; dihydroorotate oxidase activity; dihydrouracil dehydrogenase (NAD+) activity; metal ion binding; pyrimidine nucleobase catabolic process" IPR017896; IPR017900; IPR013785; IPR005720; IPR012135; NAD-dependent dihydropyrimidine dehydrogenase subunit PreA (DPD) (EC 1.3.1.1) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) preA yeiA STM2187 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) TR42465_c1_g3_i4 Q28007 DPYD_BOVIN 1.00E-140 GO:0051539; GO:0050661; GO:0006222; GO:0019483; GO:0005737; GO:0004158; GO:0017113; GO:0046872; GO:0042803; GO:0006214; GO:0006212 "4 iron, 4 sulfur cluster binding; NADP binding; UMP biosynthetic process; beta-alanine biosynthetic process; cytoplasm; dihydroorotate oxidase activity; dihydropyrimidine dehydrogenase (NADP+) activity; metal ion binding; protein homodimerization activity; thymidine catabolic process; uracil catabolic process" IPR017896; IPR017900; IPR013785; IPR005720; IPR012135; IPR028261; IPR009051; Amino-acid biosynthesis; beta-alanine biosynthesis. Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) DPYD Bos taurus (Bovine) TR42465_c1_g3_i5 A9KKR5 PYRDB_CLOPH 1.00E-08 GO:0044205; GO:0006207; GO:0005737; GO:0004158; GO:0004589 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; cytoplasm; dihydroorotate oxidase activity; orotate reductase (NADH) activity IPR013785; IPR005720; IPR024920; IPR012135; IPR001295; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD(+) route): step 1/1. "Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit (DHOD B) (DHODase B) (DHOdehase B) (EC 1.3.1.14) (Dihydroorotate oxidase B) (Orotate reductase (NADH))" pyrD Cphy_2286 Clostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) TR42466_c0_g1_i1 Q3UKU1 ELL2_MOUSE 4.00E-23 GO:0006355; GO:0008023; GO:0006368 "regulation of transcription, DNA-dependent; transcription elongation factor complex; transcription elongation from RNA polymerase II promoter" IPR010844; IPR019464; RNA polymerase II elongation factor ELL2 Ell2 Mus musculus (Mouse) TR42467_c0_g2_i1 Q24270 CAC1D_DROME 0 GO:0016324; GO:0016323; GO:0042045; GO:0046872; GO:0006936; GO:0005245; GO:0005891 apical plasma membrane; basolateral plasma membrane; epithelial fluid transport; metal ion binding; muscle contraction; voltage-gated calcium channel activity; voltage-gated calcium channel complex IPR027359; IPR005821; IPR014873; IPR005446; IPR002077; Voltage-dependent calcium channel type D subunit alpha-1 (DmCa1D) Ca-alpha1D DroCa1 l(2)35Fa CG4894 Drosophila melanogaster (Fruit fly) TR42467_c0_g2_i2 O35505 CAC1C_CAVPO 2.00E-55 GO:0005245; GO:0005891 voltage-gated calcium channel activity; voltage-gated calcium channel complex IPR005821; IPR002077; "Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2) (Fragment)" CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1 Cavia porcellus (Guinea pig) TR42468_c1_g2_i3 Q8R3N1 NOP14_MOUSE 7.00E-66 GO:0005730; GO:0006364; GO:0042274; GO:0032040; GO:0030515 nucleolus; rRNA processing; ribosomal small subunit biogenesis; small-subunit processome; snoRNA binding IPR007276; Nucleolar protein 14 (Nucleolar complex protein 14) Nop14 Nol14 Mus musculus (Mouse) TR42469_c0_g2_i1 Q5F3N0 SPX3_CHICK 3.00E-168 GO:0008643; GO:0016021; GO:0055085; GO:0005215 carbohydrate transport; integral to membrane; transmembrane transport; transporter activity IPR011701; IPR020846; IPR016196; IPR000849; Sugar phosphate exchanger 3 (Solute carrier family 37 member 3) SLC37A3 SPX3 RCJMB04_12a19 Gallus gallus (Chicken) TR42469_c0_g2_i2 Q9SA71 GLPT3_ARATH 1.00E-57 GO:0008643; GO:0016021; GO:0055062; GO:0055085; GO:0005215 carbohydrate transport; integral to membrane; phosphate ion homeostasis; transmembrane transport; transporter activity IPR011701; IPR020846; IPR016196; IPR000849; Putative glycerol-3-phosphate transporter 3 (G-3-P transporter 3) (Glycerol-3-phosphate permease 3) (AtG3Pp3) (G-3-P permease 3) At1g30560 T5I8.1 Arabidopsis thaliana (Mouse-ear cress) TR42469_c0_g2_i3 Q9C5L3 GLPT1_ARATH 3.00E-71 GO:0008643; GO:0016021; GO:0055062; GO:0055085; GO:0005215 carbohydrate transport; integral to membrane; phosphate ion homeostasis; transmembrane transport; transporter activity IPR011701; IPR020846; IPR016196; IPR000849; Putative glycerol-3-phosphate transporter 1 (G-3-P transporter 1) (Glycerol-3-phosphate permease 1) (AtG3Pp1) (G-3-P permease 1) (Protein PHOSPHATE STARVATION-INDUCED GENE 3) (AtPS3) At3g47420 T21L8.170 Arabidopsis thaliana (Mouse-ear cress) TR42469_c0_g2_i4 Q17QZ3 SPX3_BOVIN 2.00E-152 GO:0008643; GO:0016021; GO:0055085; GO:0005215 carbohydrate transport; integral to membrane; transmembrane transport; transporter activity IPR011701; IPR020846; IPR016196; IPR000849; Sugar phosphate exchanger 3 (Solute carrier family 37 member 3) SLC37A3 SPX3 Bos taurus (Bovine) TR42469_c0_g2_i5 Q5F3N0 SPX3_CHICK 6.00E-168 GO:0008643; GO:0016021; GO:0055085; GO:0005215 carbohydrate transport; integral to membrane; transmembrane transport; transporter activity IPR011701; IPR020846; IPR016196; IPR000849; Sugar phosphate exchanger 3 (Solute carrier family 37 member 3) SLC37A3 SPX3 RCJMB04_12a19 Gallus gallus (Chicken) TR42469_c0_g2_i6 Q5F3N0 SPX3_CHICK 3.00E-171 GO:0008643; GO:0016021; GO:0055085; GO:0005215 carbohydrate transport; integral to membrane; transmembrane transport; transporter activity IPR011701; IPR020846; IPR016196; IPR000849; Sugar phosphate exchanger 3 (Solute carrier family 37 member 3) SLC37A3 SPX3 RCJMB04_12a19 Gallus gallus (Chicken) TR42470_c0_g2_i1 Q05945 HSP70_HYDOL 6.00E-58 GO:0005524; GO:0006950 ATP binding; response to stress IPR018181; IPR013126; Heat shock 70 kDa protein (Fragment) HSP70 Hydra oligactis (Hydra) TR42470_c0_g2_i3 Q92260 HSP70_PENCI 0 GO:0005524; GO:0006950 ATP binding; response to stress IPR018181; IPR013126; Heat shock 70 kDa protein (allergen Pen c 19) (Fragment) HSP70 Penicillium citrinum TR42470_c0_g2_i5 P22623 HSP72_PARLI 0 GO:0005524; GO:0006950 ATP binding; response to stress IPR018181; IPR013126; Heat shock 70 kDa protein II (HSP70 II) (Fragment) HSP70II Paracentrotus lividus (Common sea urchin) TR42470_c0_g2_i7 P41827 HSP74_ANOAL 0 GO:0005524; GO:0006950 ATP binding; response to stress IPR018181; IPR013126; Heat shock protein 70 B2 HSP70B2 HSP11-C-L Anopheles albimanus (New world malaria mosquito) TR42470_c0_g2_i8 P41827 HSP74_ANOAL 0 GO:0005524; GO:0006950 ATP binding; response to stress IPR018181; IPR013126; Heat shock protein 70 B2 HSP70B2 HSP11-C-L Anopheles albimanus (New world malaria mosquito) TR42470_c0_g4_i1 Q03682 BIP2_TOBAC 3.00E-52 GO:0005524; GO:0005788 ATP binding; endoplasmic reticulum lumen IPR013126; Luminal-binding protein 2 (BiP 2) (78 kDa glucose-regulated protein homolog 2) (GRP-78-2) (Fragment) BIP2 Nicotiana tabacum (Common tobacco) TR42471_c4_g1_i1 P37020 GEF1_YEAST 5.00E-26 GO:0005797; GO:0000139; GO:0030554; GO:0006878; GO:0006879; GO:0034707; GO:0005783; GO:0005789; GO:0005768; GO:0010008; GO:0000324; GO:0005886; GO:0005774; GO:0005247 Q12154 Golgi medial cisterna; Golgi membrane; adenyl nucleotide binding; cellular copper ion homeostasis; cellular iron ion homeostasis; chloride channel complex; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; endosome membrane; fungal-type vacuole; plasma membrane; vacuolar membrane; voltage-gated chloride channel activity IPR000644; IPR014743; IPR001807; Anion/proton exchange transporter GEF1 (CLC protein GEF1) (ClC-A) (ClC-Y1) (Voltage-gated chloride channel) [Cleaved into: GEF1 N-terminal; GEF1 C-terminal] GEF1 CLCY1 YJR040W J1616 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42471_c4_g1_i2 Q9R279 CLCN3_CAVPO 4.00E-141 GO:0005524; GO:0005794; GO:0030165; GO:0015297; GO:0005769; GO:0031901; GO:0016021; GO:0005770; GO:0031902; GO:0030658; GO:0012506; GO:0005247 ATP binding; Golgi apparatus; PDZ domain binding; antiporter activity; early endosome; early endosome membrane; integral to membrane; late endosome; late endosome membrane; transport vesicle membrane; vesicle membrane; voltage-gated chloride channel activity IPR000644; IPR014743; IPR001807; IPR002245; H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3) CLCN3 Cavia porcellus (Guinea pig) TR42472_c0_g2_i1 Q5TYW4 NBAS_DANRE 0 GO:0009790; GO:0000184 "embryo development; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" IPR013244; IPR015943; IPR001680; IPR017986; Neuroblastoma-amplified sequence (Neuroblastoma-amplified gene protein homolog) nbas nag si:ch211-214k9.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR42473_c3_g1_i2 Q94AS5 ICME_ARATH 2.00E-18 GO:0000139; GO:0005789; GO:0016021; GO:0010296 Golgi membrane; endoplasmic reticulum membrane; integral to membrane; prenylcysteine methylesterase activity IPR013094; IPR019826; Isoprenylcysteine alpha-carbonyl methylesterase ICME (EC 3.1.1.n2) (Isoprenylcysteine methylesterase) (Prenylcysteine methylesterase) (AtPCME) ICME PCME At5g15860 F14F8.240 Arabidopsis thaliana (Mouse-ear cress) TR42474_c1_g1_i1 P54213 CATR_DUNSA 7.00E-36 GO:0005509; GO:0051301; GO:0007067 calcium ion binding; cell division; mitosis IPR011992; IPR018247; IPR002048; Caltractin (Centrin) Dunaliella salina (Green alga) TR42474_c1_g1_i4 Q38872 CDPK6_ARATH 6.00E-14 GO:0005524; GO:0009738; GO:0005509; GO:0005829; GO:0005886; GO:0046777; GO:0004674; GO:0010359; GO:0010119 ATP binding; abscisic acid mediated signaling pathway; calcium ion binding; cytosol; plasma membrane; protein autophosphorylation; protein serine/threonine kinase activity; regulation of anion channel activity; regulation of stomatal movement IPR011992; IPR018247; IPR002048; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium-dependent protein kinase 6 (EC 2.7.11.1) (Calcium-dependent protein kinase isoform CDPK3) (AtCDPK3) (Calmodulin-domain protein kinase CDPK isoform 6) CPK6 CDPK3 At2g17290 F5J6.13 Arabidopsis thaliana (Mouse-ear cress) TR42474_c1_g1_i5 P54213 CATR_DUNSA 2.00E-34 GO:0005509; GO:0051301; GO:0007067 calcium ion binding; cell division; mitosis IPR011992; IPR018247; IPR002048; Caltractin (Centrin) Dunaliella salina (Green alga) TR42474_c1_g1_i8 O49717 CDPKF_ARATH 2.00E-14 GO:0005524; GO:0005509; GO:0016020; GO:0004674 ATP binding; calcium ion binding; membrane; protein serine/threonine kinase activity IPR011992; IPR018247; IPR002048; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Calcium-dependent protein kinase 15 (EC 2.7.11.1) CPK15 At4g21940 F1N20.5 T8O5.150 Arabidopsis thaliana (Mouse-ear cress) TR42475_c2_g1_i3 Q9VVY3 GBS76_DROME 2.00E-42 P48462 IPR005036; Glycogen-binding subunit 76A (CBM21 domain-containing protein CG9619) Gbs-76A CG9619 Drosophila melanogaster (Fruit fly) TR42475_c2_g1_i5 Q9VVY3 GBS76_DROME 2.00E-42 P48462 IPR005036; Glycogen-binding subunit 76A (CBM21 domain-containing protein CG9619) Gbs-76A CG9619 Drosophila melanogaster (Fruit fly) TR42476_c1_g4_i1 E1C231 LTN1_CHICK 2.00E-179 GO:0051865; GO:0004842; GO:0008270 protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR016024; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase listerin (EC 6.3.2.-) (RING finger protein 160) (Zfp-294) LTN1 RNF160 Gallus gallus (Chicken) TR42476_c1_g4_i2 E1C231 LTN1_CHICK 2.00E-44 GO:0051865; GO:0004842; GO:0008270 protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR016024; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase listerin (EC 6.3.2.-) (RING finger protein 160) (Zfp-294) LTN1 RNF160 Gallus gallus (Chicken) TR42476_c1_g4_i3 Q9VW09 LTN1_DROME 7.00E-29 GO:0016874; GO:0016567; GO:0008270 ligase activity; protein ubiquitination; zinc ion binding IPR011989; IPR016024; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase listerin (EC 6.3.2.-) l(3)76BDr CG32210 Drosophila melanogaster (Fruit fly) TR42477_c1_g1_i1 Q8WPD0 LECG_ASTPE 2.00E-12 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Alpha-N-acetylgalactosamine-specific lectin (Alpha-N-acetylgalactosamine-binding lectin) (GalNAc-specific lectin) (Lectin) (ApL) (Tn antigen-specific lectin) Patiria pectinifera (Starfish) (Asterina pectinifera) TR42477_c2_g8_i12 A8QZJ5 MCTX1_MILDI 6.00E-33 GO:0005576; GO:0042151 extracellular region; nematocyst IPR026645; Millepora cytotoxin-1 (MCTx-1) Millepora dichotoma (Net fire coral) TR42478_c0_g2_i2 O74945 RIA1_SCHPO 2.00E-44 GO:0005525; GO:0006184; GO:0003924; GO:0005829; GO:0042254 GTP binding; GTP catabolic process; GTPase activity; cytosol; ribosome biogenesis IPR000795; IPR009022; IPR000640; IPR027417; IPR020568; IPR014721; IPR005225; IPR009000; IPR005517; IPR004161; Ribosome assembly protein 1 (EC 3.6.5.-) (EF-2 like GTPase) (Elongation factor-like 1) ria1 SPCC553.08c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42478_c0_g6_i1 Q6BJ25 EF2_DEBHA 0 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; translation elongation factor activity IPR000795; IPR009022; IPR000640; IPR027417; IPR020568; IPR014721; IPR005225; IPR009000; IPR005517; IPR004161; Elongation factor 2 (EF-2) EFT1 DEHA2G05742g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) TR42478_c0_g6_i2 Q3SYU2 EF2_BOVIN 0 GO:0005525; GO:0003924; GO:0005737; GO:0005844; GO:0003746 GTP binding; GTPase activity; cytoplasm; polysome; translation elongation factor activity IPR000795; IPR009022; IPR000640; IPR027417; IPR020568; IPR014721; IPR005225; IPR009000; IPR005517; IPR004161; Elongation factor 2 (EF-2) EEF2 Bos taurus (Bovine) TR42479_c2_g1_i1 P12606 ITB1A_XENLA 5.00E-102 GO:0007160; GO:0032154; GO:0008305; GO:0007229; GO:0030027; GO:0042470; GO:0007275; GO:0004872; GO:0001726 cell-matrix adhesion; cleavage furrow; integrin complex; integrin-mediated signaling pathway; lamellipodium; melanosome; multicellular organismal development; receptor activity; ruffle IPR013111; IPR027071; IPR015812; IPR014836; IPR002369; IPR012896; IPR016201; IPR002035; Integrin beta-1-A itgb1-a Xenopus laevis (African clawed frog) TR42479_c2_g1_i2 P22105 TENX_HUMAN 3.00E-18 GO:0030036; GO:0007155; GO:0016337; GO:0007160; GO:0030199; GO:0032963; GO:0048251; GO:0043206; GO:0005615; GO:0006631; GO:0008201; GO:0005178; GO:0005622; GO:0005578; GO:0043506; GO:0006641 actin cytoskeleton organization; cell adhesion; cell-cell adhesion; cell-matrix adhesion; collagen fibril organization; collagen metabolic process; elastic fiber assembly; extracellular fibril organization; extracellular space; fatty acid metabolic process; heparin binding; integrin binding; intracellular; proteinaceous extracellular matrix; regulation of JUN kinase activity; triglyceride metabolic process IPR000742; IPR013032; IPR014716; IPR014715; IPR002181; IPR020837; IPR003961; IPR013783; Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) TR42479_c2_g1_i4 Q3UV74 ITB2L_MOUSE 6.00E-38 GO:0007160; GO:0006954; GO:0008305; GO:0007229; GO:0007275; GO:0004872 cell-matrix adhesion; inflammatory response; integrin complex; integrin-mediated signaling pathway; multicellular organismal development; receptor activity IPR015812; IPR015439; IPR002369; IPR012896; IPR016201; IPR002035; Integrin beta-2-like protein (Protein pactolus) Itgb2l Mus musculus (Mouse) TR42479_c2_g3_i1 A5Z1X6 ITB1_CAMBA 5.00E-93 GO:0007160; GO:0008305; GO:0007229; GO:0030027; GO:0042470; GO:0046872; GO:0007275; GO:0004872; GO:0055037; GO:0001726 cell-matrix adhesion; integrin complex; integrin-mediated signaling pathway; lamellipodium; melanosome; metal ion binding; multicellular organismal development; receptor activity; recycling endosome; ruffle IPR013111; IPR027071; IPR015812; IPR014836; IPR002369; IPR012896; IPR016201; IPR002035; Integrin beta-1 (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29) ITGB1 Camelus bactrianus (Bactrian camel) TR42479_c2_g3_i2 Q64632 ITB4_RAT 9.00E-44 GO:0007155; GO:0050839; GO:0005938; GO:0031252; GO:0048870; GO:0007160; GO:0005615; GO:0030056; GO:0031581; GO:0008305; GO:0007229; GO:0007275; GO:0004872; GO:0009611 cell adhesion; cell adhesion molecule binding; cell cortex; cell leading edge; cell motility; cell-matrix adhesion; extracellular space; hemidesmosome; hemidesmosome assembly; integrin complex; integrin-mediated signaling pathway; multicellular organismal development; receptor activity; response to wounding IPR003644; IPR013032; IPR003961; IPR013783; IPR015812; IPR012013; IPR002369; IPR012896; IPR016201; IPR002035; Integrin beta-4 (GP150) (CD antigen CD104) Itgb4 Rattus norvegicus (Rat) TR42480_c2_g7_i1 A2AX52 CO6A4_MOUSE 1.00E-64 GO:0007155; GO:0005581; GO:0005576; GO:0043234; GO:0070208 cell adhesion; collagen; extracellular region; protein complex; protein heterotrimerization IPR008160; IPR002035; Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) TR42480_c2_g7_i2 P32018 COEA1_CHICK 3.00E-29 GO:0007155; GO:0005581 cell adhesion; collagen IPR008160; IPR008985; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XIV) chain (Undulin) COL14A1 Gallus gallus (Chicken) TR42480_c2_g7_i3 A2AX52 CO6A4_MOUSE 3.00E-23 GO:0007155; GO:0005581; GO:0005576; GO:0043234; GO:0070208 cell adhesion; collagen; extracellular region; protein complex; protein heterotrimerization IPR008160; IPR002035; Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) TR42482_c0_g1_i1 P40201 CHD1_MOUSE 3.00E-36 GO:0005524; GO:0003677; GO:0006333; GO:0003682; GO:0006338; GO:0005737; GO:0004386; GO:0005634; GO:0006355; GO:0006351 "ATP binding; DNA binding; chromatin assembly or disassembly; chromatin binding; chromatin remodeling; cytoplasm; helicase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR023780; IPR000953; IPR016197; IPR023779; IPR025260; IPR014001; IPR001650; IPR027417; IPR000330; Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase CHD1) Chd1 Chd-1 Mus musculus (Mouse) TR42482_c0_g1_i3 Q7KU24 CHD1_DROME 6.00E-28 GO:0005524; GO:0008026; GO:0003677; GO:0003682; GO:0035042; GO:0004386; GO:0007476; GO:0005634; GO:0048477; GO:0005705; GO:0005703; GO:0006355; GO:0006351 "ATP binding; ATP-dependent helicase activity; DNA binding; chromatin binding; fertilization, exchange of chromosomal proteins; helicase activity; imaginal disc-derived wing morphogenesis; nucleus; oogenesis; polytene chromosome interband; polytene chromosome puff; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR023780; IPR000953; IPR016197; IPR023779; IPR002464; IPR025260; IPR014001; IPR001650; IPR027417; IPR000330; Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase Chd1) Chd1 CG3733 Drosophila melanogaster (Fruit fly) TR42482_c0_g1_i8 P40201 CHD1_MOUSE 3.00E-36 GO:0005524; GO:0003677; GO:0006333; GO:0003682; GO:0006338; GO:0005737; GO:0004386; GO:0005634; GO:0006355; GO:0006351 "ATP binding; DNA binding; chromatin assembly or disassembly; chromatin binding; chromatin remodeling; cytoplasm; helicase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR023780; IPR000953; IPR016197; IPR023779; IPR025260; IPR014001; IPR001650; IPR027417; IPR000330; Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase CHD1) Chd1 Chd-1 Mus musculus (Mouse) TR42482_c0_g1_i9 P40201 CHD1_MOUSE 2.00E-36 GO:0005524; GO:0003677; GO:0006333; GO:0003682; GO:0006338; GO:0005737; GO:0004386; GO:0005634; GO:0006355; GO:0006351 "ATP binding; DNA binding; chromatin assembly or disassembly; chromatin binding; chromatin remodeling; cytoplasm; helicase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR023780; IPR000953; IPR016197; IPR023779; IPR025260; IPR014001; IPR001650; IPR027417; IPR000330; Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase CHD1) Chd1 Chd-1 Mus musculus (Mouse) TR42484_c3_g3_i1 P12263 FA8_PIG 7.00E-39 GO:0006953; GO:0007596; GO:0007155; GO:0005507; GO:0005615; GO:0016491 acute-phase response; blood coagulation; cell adhesion; copper ion binding; extracellular space; oxidoreductase activity IPR000421; IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; IPR008979; Coagulation factor VIII (Procoagulant component) F8 CF8 Sus scrofa (Pig) TR42484_c3_g3_i2 Q9BQS7 HEPH_HUMAN 1.00E-95 GO:0006879; GO:0005507; GO:0006825; GO:0016021; GO:0006826; GO:0016491; GO:0048471; GO:0005886; GO:0055085 cellular iron ion homeostasis; copper ion binding; copper ion transport; integral to membrane; iron ion transport; oxidoreductase activity; perinuclear region of cytoplasm; plasma membrane; transmembrane transport IPR011706; IPR011707; IPR002355; IPR008972; IPR027154; Hephaestin (EC 1.-.-.-) HEPH KIAA0698 UNQ2562/PRO6242 Homo sapiens (Human) TR42486_c0_g2_i1 Q5U508 TBCE_XENLA 1.00E-80 GO:0005737; GO:0005856; GO:0007023 cytoplasm; cytoskeleton; post-chaperonin tubulin folding pathway IPR000938; IPR027933; Tubulin-specific chaperone E (Tubulin-folding cofactor E) tbce Xenopus laevis (African clawed frog) TR42487_c0_g1_i1 Q6P6Z8 ODO1_XENLA 0 GO:0006096; GO:0005759; GO:0004591; GO:0030976; GO:0006099 glycolysis; mitochondrial matrix; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding; tricarboxylic acid cycle IPR011603; IPR001017; IPR005475; "2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase)" ogdh Xenopus laevis (African clawed frog) TR42487_c0_g1_i2 P86231 ODO1_MESAU 9.00E-10 GO:0006096; GO:0005759; GO:0004591; GO:0030976; GO:0006099 glycolysis; mitochondrial matrix; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding; tricarboxylic acid cycle IPR011603; "2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase) (Fragments)" OGDH Mesocricetus auratus (Golden hamster) TR42487_c0_g1_i5 Q6P6Z8 ODO1_XENLA 0 GO:0006096; GO:0005759; GO:0004591; GO:0030976; GO:0006099 glycolysis; mitochondrial matrix; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding; tricarboxylic acid cycle IPR011603; IPR001017; IPR005475; "2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase)" ogdh Xenopus laevis (African clawed frog) TR42487_c0_g1_i6 Q60HE2 ODO1_MACFA 0 GO:0006091; GO:0006096; GO:0005759; GO:0031966; GO:0004591; GO:0030976; GO:0006099 generation of precursor metabolites and energy; glycolysis; mitochondrial matrix; mitochondrial membrane; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding; tricarboxylic acid cycle IPR011603; IPR001017; IPR005475; "2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase)" OGDH QccE-15394 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR42487_c0_g1_i8 Q6P6Z8 ODO1_XENLA 0 GO:0006096; GO:0005759; GO:0004591; GO:0030976; GO:0006099 glycolysis; mitochondrial matrix; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding; tricarboxylic acid cycle IPR011603; IPR001017; IPR005475; "2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase)" ogdh Xenopus laevis (African clawed frog) TR42488_c0_g1_i1 Q9BZH6 WDR11_HUMAN 4.00E-111 GO:0005929; GO:0016021; GO:0005765; GO:0005634 cilium; integral to membrane; lysosomal membrane; nucleus IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 11 (Bromodomain and WD repeat-containing protein 2) (WD repeat-containing protein 15) WDR11 BRWD2 KIAA1351 WDR15 Homo sapiens (Human) TR42488_c0_g2_i1 Q8K1X1 WDR11_MOUSE 7.00E-164 GO:0005929; GO:0005737; GO:0016021; GO:0005634 cilium; cytoplasm; integral to membrane; nucleus IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 11 (Bromodomain and WD repeat-containing protein 2) Wdr11 Brwd2 Kiaa1351 Mus musculus (Mouse) TR42489_c0_g1_i1 Q5YJC1 SYPH_SPECI 5.00E-35 GO:0030054; GO:0016021; GO:0043005; GO:0030672; GO:0005215 cell junction; integral to membrane; neuron projection; synaptic vesicle membrane; transporter activity IPR008253; IPR001285; Synaptophysin SYP Spermophilus citellus (European suslik) (Citellus citellus) TR42489_c0_g1_i2 Q8TBG9 SYNPR_HUMAN 3.00E-28 GO:0030054; GO:0016021; GO:0043005; GO:0030672; GO:0005215 cell junction; integral to membrane; neuron projection; synaptic vesicle membrane; transporter activity IPR008253; IPR001285; Synaptoporin SYNPR Homo sapiens (Human) TR42494_c2_g1_i1 Q9CPW0 CNTP2_MOUSE 9.00E-51 GO:0005794; GO:0030673; GO:0007155; GO:0009986; GO:0045163; GO:0030425; GO:0005769; GO:0019899; GO:0016021; GO:0044224; GO:0021761; GO:0031175; GO:0008038; GO:0043204; GO:0071205 Golgi apparatus; axolemma; cell adhesion; cell surface; clustering of voltage-gated potassium channels; dendrite; early endosome; enzyme binding; integral to membrane; juxtaparanode region of axon; limbic system development; neuron projection development; neuron recognition; perikaryon; protein localization to juxtaparanode region of axon IPR000421; IPR008985; IPR013320; IPR000742; IPR002181; IPR008979; IPR001791; IPR003585; Contactin-associated protein-like 2 (Cell recognition molecule Caspr2) Cntnap2 Kiaa0868 Mus musculus (Mouse) TR42494_c2_g1_i2 D0PRN3 NRX3A_CHICK 2.00E-11 GO:0007155; GO:0016021; GO:0046872; GO:0007269; GO:0051965; GO:0090129; GO:0007416 cell adhesion; integral to membrane; metal ion binding; neurotransmitter secretion; positive regulation of synapse assembly; positive regulation of synapse maturation; synapse assembly IPR008985; IPR013320; IPR000742; IPR000152; IPR001791; IPR003585; IPR027158; IPR027789; Neurexin-3 (Neurexin III-alpha) (Neurexin-3-alpha) Gallus gallus (Chicken) TR42494_c2_g1_i3 Q0V8T4 CTP5C_RAT 2.00E-51 GO:0007155; GO:0016021 cell adhesion; integral to membrane IPR000421; IPR008985; IPR013320; IPR000742; IPR002181; IPR008979; IPR001791; Contactin-associated protein like 5-3 (Cell recognition molecule Caspr5-3) (Cell recognition molecule Caspr5c) (Contactin-associated protein-like 5c) Cntnap5c Caspr5-3 Rattus norvegicus (Rat) TR42494_c2_g1_i4 Q8WYK1 CNTP5_HUMAN 1.00E-46 GO:0007155; GO:0016021 cell adhesion; integral to membrane IPR000421; IPR008985; IPR013320; IPR000742; IPR002181; IPR008979; IPR001791; Contactin-associated protein-like 5 (Cell recognition molecule Caspr5) CNTNAP5 CASPR5 Homo sapiens (Human) TR42494_c2_g1_i5 D0PRN3 NRX3A_CHICK 2.00E-11 GO:0007155; GO:0016021; GO:0046872; GO:0007269; GO:0051965; GO:0090129; GO:0007416 cell adhesion; integral to membrane; metal ion binding; neurotransmitter secretion; positive regulation of synapse assembly; positive regulation of synapse maturation; synapse assembly IPR008985; IPR013320; IPR000742; IPR000152; IPR001791; IPR003585; IPR027158; IPR027789; Neurexin-3 (Neurexin III-alpha) (Neurexin-3-alpha) Gallus gallus (Chicken) TR42494_c2_g1_i6 Q9CPW0 CNTP2_MOUSE 8.00E-51 GO:0005794; GO:0030673; GO:0007155; GO:0009986; GO:0045163; GO:0030425; GO:0005769; GO:0019899; GO:0016021; GO:0044224; GO:0021761; GO:0031175; GO:0008038; GO:0043204; GO:0071205 Golgi apparatus; axolemma; cell adhesion; cell surface; clustering of voltage-gated potassium channels; dendrite; early endosome; enzyme binding; integral to membrane; juxtaparanode region of axon; limbic system development; neuron projection development; neuron recognition; perikaryon; protein localization to juxtaparanode region of axon IPR000421; IPR008985; IPR013320; IPR000742; IPR002181; IPR008979; IPR001791; IPR003585; Contactin-associated protein-like 2 (Cell recognition molecule Caspr2) Cntnap2 Kiaa0868 Mus musculus (Mouse) TR42494_c2_g1_i7 Q0V8S9 CNTP5_CHICK 2.00E-50 GO:0007155; GO:0016021 cell adhesion; integral to membrane IPR000421; IPR008985; IPR013320; IPR000742; IPR002181; IPR008979; IPR001791; Contactin-associated protein-like 5 (Cell recognition molecule Caspr5) CNTNAP5 CASPR5 Gallus gallus (Chicken) TR42495_c0_g1_i1 E9Q349 WDR25_MOUSE 1.00E-32 IPR015943; IPR001680; IPR017986; WD repeat-containing protein 25 Wdr25 Mus musculus (Mouse) TR42495_c0_g1_i3 Q3ULA2 FBW1A_MOUSE 5.00E-14 GO:0019005; GO:0016055; GO:0008013; GO:0060444; GO:0071407; GO:0005829; GO:0033598; GO:0045892; GO:0005634; GO:0042753; GO:0045862; GO:0045893; GO:0006470; GO:0031648; GO:0045309; GO:0000209; GO:0043122; GO:0051726; GO:0061136; GO:0006511; GO:0004842 "SCF ubiquitin ligase complex; Wnt receptor signaling pathway; beta-catenin binding; branching involved in mammary gland duct morphogenesis; cellular response to organic cyclic compound; cytosol; mammary gland epithelial cell proliferation; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of circadian rhythm; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; protein dephosphorylation; protein destabilization; protein phosphorylated amino acid binding; protein polyubiquitination; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of cell cycle; regulation of proteasomal protein catabolic process; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity" IPR021977; IPR001810; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. F-box/WD repeat-containing protein 1A (Beta-TrCP protein E3RS-IkappaB) (Beta-transducin repeat-containing protein) (Beta-TrCP) (E3RSIkappaB) (mE3RS-IkappaB) (F-box and WD repeats protein beta-TrCP) (HOS) (Ubiquitin ligase FWD1) (pIkappaB-E3 receptor subunit) Btrc Fbw1 Fbxw1 Fwd1 Kiaa4123 Mus musculus (Mouse) TR42495_c0_g1_i4 Q9DC48 PRP17_MOUSE 4.00E-169 GO:0008380; GO:0071013; GO:0006397 RNA splicing; catalytic step 2 spliceosome; mRNA processing IPR015943; IPR001680; IPR019775; IPR017986; Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (PRP17 homolog) Cdc40 Prp17 Prpf17 Mus musculus (Mouse) TR42495_c0_g4_i1 A8IR43 WDR12_CHLRE 6.00E-07 GO:0080008; GO:0001510; GO:0000478; GO:0005834; GO:0005730; GO:0005654; GO:0000166; GO:0009506; GO:0006606; GO:0051604; GO:0006626 Cul4-RING ubiquitin ligase complex; RNA methylation; endonucleolytic cleavage involved in rRNA processing; heterotrimeric G-protein complex; nucleolus; nucleoplasm; nucleotide binding; plasmodesma; protein import into nucleus; protein maturation; protein targeting to mitochondrion IPR020472; IPR012972; IPR015943; IPR001680; IPR019775; IPR017986; Ribosome biogenesis protein WDR12 homolog CHLREDRAFT_128420 Chlamydomonas reinhardtii (Chlamydomonas smithii) TR42496_c0_g2_i1 B4J6N6 EAF_DROGR 8.00E-28 GO:0032783; GO:0007275; GO:0005654; GO:0045893; GO:0006351 "ELL-EAF complex; multicellular organismal development; nucleoplasm; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR027093; IPR019194; Ell-associated factor Eaf Eaf GH20739 Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) TR42496_c0_g3_i1 Q96CJ1 EAF2_HUMAN 3.00E-27 GO:0032783; GO:0006915; GO:0030308; GO:0060770; GO:0016607; GO:0005634; GO:0045893; GO:0006351 P0C1Z6 "ELL-EAF complex; apoptotic process; negative regulation of cell growth; negative regulation of epithelial cell proliferation involved in prostate gland development; nuclear speck; nucleus; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR027093; IPR019194; ELL-associated factor 2 (Testosterone-regulated apoptosis inducer and tumor suppressor protein) EAF2 TRAITS BM-040 Homo sapiens (Human) TR42497_c2_g3_i4 Q64213 SF01_MOUSE 1.00E-115 GO:0033327; GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0030238; GO:0005634; GO:0050810; GO:0006355; GO:0005681; GO:0006351; GO:0008270 "Leydig cell differentiation; RNA binding; RNA splicing; cytoplasm; mRNA processing; male sex determination; nucleus; regulation of steroid biosynthetic process; regulation of transcription, DNA-dependent; spliceosomal complex; transcription, DNA-dependent; zinc ion binding" IPR004087; IPR004088; IPR001878; Splicing factor 1 (CW17) (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (mZFM) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162) Sf1 Zfm1 Zfp162 Mus musculus (Mouse) TR42497_c2_g3_i5 Q5AED9 BBP_CANAL 3.00E-41 GO:0003723; GO:0008380; GO:0006397; GO:0005681; GO:0008270 RNA binding; RNA splicing; mRNA processing; spliceosomal complex; zinc ion binding IPR004087; IPR004088; IPR001878; Branchpoint-bridging protein BBP MSL5 CaO19.329 CaO19.7961 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) TR42498_c0_g1_i1 A1L0Y2 NEUL4_XENTR 2.00E-124 GO:0005814 centriole IPR008985; IPR006573; Neuralized-like protein 4 neurl4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42498_c0_g1_i6 A1L0Y2 NEUL4_XENTR 7.00E-123 GO:0005814 centriole IPR008985; IPR006573; Neuralized-like protein 4 neurl4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42498_c0_g1_i8 A1L0Y2 NEUL4_XENTR 3.00E-123 GO:0005814 centriole IPR008985; IPR006573; Neuralized-like protein 4 neurl4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42500_c2_g1_i1 E1BGQ2 ZCHC4_BOVIN 6.00E-126 GO:0008168; GO:0003676; GO:0008270 methyltransferase activity; nucleic acid binding; zinc ion binding IPR002052; IPR019369; IPR001878; IPR001594; IPR010666; Zinc finger CCHC domain-containing protein 4 ZCCHC4 Bos taurus (Bovine) TR42500_c2_g1_i2 Q8BKW4 ZCHC4_MOUSE 5.00E-136 GO:0008168; GO:0003676; GO:0008270 methyltransferase activity; nucleic acid binding; zinc ion binding IPR002052; IPR019369; IPR001878; IPR001594; IPR010666; Zinc finger CCHC domain-containing protein 4 Zcchc4 Mus musculus (Mouse) TR42501_c1_g1_i13 Q801X6 PHAR1_CHICK 8.00E-51 GO:0003779; GO:0031532; GO:0031032; GO:0030054; GO:0005829; GO:0005634; GO:0004864; GO:0043149; GO:0045202 actin binding; actin cytoskeleton reorganization; actomyosin structure organization; cell junction; cytosol; nucleus; protein phosphatase inhibitor activity; stress fiber assembly; synapse IPR004018; Phosphatase and actin regulator 1 PHACTR1 DDSG1 Gallus gallus (Chicken) TR42501_c1_g1_i15 Q801X6 PHAR1_CHICK 8.00E-51 GO:0003779; GO:0031532; GO:0031032; GO:0030054; GO:0005829; GO:0005634; GO:0004864; GO:0043149; GO:0045202 actin binding; actin cytoskeleton reorganization; actomyosin structure organization; cell junction; cytosol; nucleus; protein phosphatase inhibitor activity; stress fiber assembly; synapse IPR004018; Phosphatase and actin regulator 1 PHACTR1 DDSG1 Gallus gallus (Chicken) TR42501_c1_g1_i18 Q801X6 PHAR1_CHICK 8.00E-51 GO:0003779; GO:0031532; GO:0031032; GO:0030054; GO:0005829; GO:0005634; GO:0004864; GO:0043149; GO:0045202 actin binding; actin cytoskeleton reorganization; actomyosin structure organization; cell junction; cytosol; nucleus; protein phosphatase inhibitor activity; stress fiber assembly; synapse IPR004018; Phosphatase and actin regulator 1 PHACTR1 DDSG1 Gallus gallus (Chicken) TR42501_c1_g1_i20 Q801X6 PHAR1_CHICK 8.00E-51 GO:0003779; GO:0031532; GO:0031032; GO:0030054; GO:0005829; GO:0005634; GO:0004864; GO:0043149; GO:0045202 actin binding; actin cytoskeleton reorganization; actomyosin structure organization; cell junction; cytosol; nucleus; protein phosphatase inhibitor activity; stress fiber assembly; synapse IPR004018; Phosphatase and actin regulator 1 PHACTR1 DDSG1 Gallus gallus (Chicken) TR42501_c1_g1_i21 F7EC58 PHAR4_XENTR 2.00E-24 GO:0007266; GO:0003779; GO:0030036; GO:0061386; GO:0005737; GO:0048484; GO:0030027; GO:2001045; GO:0001755; GO:0001843; GO:0008157; GO:0071862; GO:0051726 Rho protein signal transduction; actin binding; actin cytoskeleton organization; closure of optic fissure; cytoplasm; enteric nervous system development; lamellipodium; negative regulation of integrin-mediated signaling pathway; neural crest cell migration; neural tube closure; protein phosphatase 1 binding; protein phosphatase type 1 activator activity; regulation of cell cycle IPR004018; Phosphatase and actin regulator 4 phactr4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42501_c1_g1_i5 Q801X6 PHAR1_CHICK 7.00E-51 GO:0003779; GO:0031532; GO:0031032; GO:0030054; GO:0005829; GO:0005634; GO:0004864; GO:0043149; GO:0045202 actin binding; actin cytoskeleton reorganization; actomyosin structure organization; cell junction; cytosol; nucleus; protein phosphatase inhibitor activity; stress fiber assembly; synapse IPR004018; Phosphatase and actin regulator 1 PHACTR1 DDSG1 Gallus gallus (Chicken) TR42501_c1_g1_i7 Q801X6 PHAR1_CHICK 8.00E-51 GO:0003779; GO:0031532; GO:0031032; GO:0030054; GO:0005829; GO:0005634; GO:0004864; GO:0043149; GO:0045202 actin binding; actin cytoskeleton reorganization; actomyosin structure organization; cell junction; cytosol; nucleus; protein phosphatase inhibitor activity; stress fiber assembly; synapse IPR004018; Phosphatase and actin regulator 1 PHACTR1 DDSG1 Gallus gallus (Chicken) TR42501_c1_g1_i9 Q801X6 PHAR1_CHICK 8.00E-51 GO:0003779; GO:0031532; GO:0031032; GO:0030054; GO:0005829; GO:0005634; GO:0004864; GO:0043149; GO:0045202 actin binding; actin cytoskeleton reorganization; actomyosin structure organization; cell junction; cytosol; nucleus; protein phosphatase inhibitor activity; stress fiber assembly; synapse IPR004018; Phosphatase and actin regulator 1 PHACTR1 DDSG1 Gallus gallus (Chicken) TR42504_c0_g2_i1 Q95XU6 ZC3HE_CAEEL 2.00E-15 GO:0046872; GO:0005634; GO:0048471 metal ion binding; nucleus; perinuclear region of cytoplasm IPR000571; Zinc finger CCCH domain-containing protein 14 (Suppressor of tau pathology protein 2) sut-2 Y61A9LA.8 Caenorhabditis elegans TR42504_c0_g4_i2 Q5TYQ8 ZC3HE_DANRE 4.00E-26 GO:0003723; GO:0046872; GO:0016607; GO:0005634 RNA binding; metal ion binding; nuclear speck; nucleus Zinc finger CCCH domain-containing protein 14 zc3h14 si:dkey-199i12.4 zgc:136266 Danio rerio (Zebrafish) (Brachydanio rerio) TR42505_c2_g2_i1 Q9Y236 OSGI2_HUMAN 1.00E-39 GO:0007281; GO:0007126 germ cell development; meiosis Oxidative stress-induced growth inhibitor 2 (hT41) OSGIN2 C8orf1 Homo sapiens (Human) TR42505_c2_g3_i10 Q9Y236 OSGI2_HUMAN 2.00E-20 GO:0007281; GO:0007126 germ cell development; meiosis Oxidative stress-induced growth inhibitor 2 (hT41) OSGIN2 C8orf1 Homo sapiens (Human) TR42505_c2_g3_i15 Q9Y236 OSGI2_HUMAN 2.00E-20 GO:0007281; GO:0007126 germ cell development; meiosis Oxidative stress-induced growth inhibitor 2 (hT41) OSGIN2 C8orf1 Homo sapiens (Human) TR42506_c1_g1_i10 P52899 ODPA_CAEEL 1.00E-164 GO:0006096; GO:0005759; GO:0005739; GO:0004739 glycolysis; mitochondrial matrix; mitochondrion; pyruvate dehydrogenase (acetyl-transferring) activity IPR001017; IPR017597; "Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (PDHE1-A) (EC 1.2.4.1)" T05H10.6 Caenorhabditis elegans TR42506_c1_g1_i11 P35486 ODPA_MOUSE 4.00E-172 GO:0006086; GO:0006096; GO:0005759; GO:0005739; GO:0004739; GO:0004738; GO:0045254; GO:0006099 acetyl-CoA biosynthetic process from pyruvate; glycolysis; mitochondrial matrix; mitochondrion; pyruvate dehydrogenase (acetyl-transferring) activity; pyruvate dehydrogenase activity; pyruvate dehydrogenase complex; tricarboxylic acid cycle IPR001017; IPR017597; "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)" Pdha1 Pdha-1 Mus musculus (Mouse) TR42506_c1_g1_i3 P35486 ODPA_MOUSE 4.00E-170 GO:0006086; GO:0006096; GO:0005759; GO:0005739; GO:0004739; GO:0004738; GO:0045254; GO:0006099 acetyl-CoA biosynthetic process from pyruvate; glycolysis; mitochondrial matrix; mitochondrion; pyruvate dehydrogenase (acetyl-transferring) activity; pyruvate dehydrogenase activity; pyruvate dehydrogenase complex; tricarboxylic acid cycle IPR001017; IPR017597; "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)" Pdha1 Pdha-1 Mus musculus (Mouse) TR42506_c1_g1_i5 P26268 ODPT_ASCSU 8.00E-162 GO:0006096; GO:0005759; GO:0004739; GO:0006099 glycolysis; mitochondrial matrix; pyruvate dehydrogenase (acetyl-transferring) activity; tricarboxylic acid cycle IPR001017; IPR017597; "Pyruvate dehydrogenase E1 component subunit alpha type II, mitochondrial (PDHA2) (PDHE1-A) (EC 1.2.4.1) (Fragment)" Ascaris suum (Pig roundworm) (Ascaris lumbricoides) TR42506_c1_g1_i6 P35486 ODPA_MOUSE 7.00E-168 GO:0006086; GO:0006096; GO:0005759; GO:0005739; GO:0004739; GO:0004738; GO:0045254; GO:0006099 acetyl-CoA biosynthetic process from pyruvate; glycolysis; mitochondrial matrix; mitochondrion; pyruvate dehydrogenase (acetyl-transferring) activity; pyruvate dehydrogenase activity; pyruvate dehydrogenase complex; tricarboxylic acid cycle IPR001017; IPR017597; "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)" Pdha1 Pdha-1 Mus musculus (Mouse) TR42508_c0_g1_i1 Q91VX9 TM168_MOUSE 2.00E-92 GO:0016021; GO:0030133 integral to membrane; transport vesicle Transmembrane protein 168 Tmem168 Mus musculus (Mouse) TR42508_c2_g2_i2 Q99LS1 MMAD_MOUSE 7.00E-54 GO:0009235; GO:0005739 cobalamin metabolic process; mitochondrion IPR019362; "Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial" Mmadhc Mus musculus (Mouse) TR42508_c3_g1_i1 Q7ZY86 TM168_XENLA 1.00E-35 GO:0016021 integral to membrane Transmembrane protein 168 tmem168 Xenopus laevis (African clawed frog) TR42510_c5_g1_i1 P22061 PIMT_HUMAN 1.00E-93 GO:0005783; GO:0030091; GO:0004719 Itself; O60739; P23506; P40337 endoplasmic reticulum; protein repair; protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IPR000682; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) PCMT1 Homo sapiens (Human) TR42510_c5_g1_i5 Q4R5H0 PIMT_MACFA 2.00E-57 GO:0005737; GO:0004719 cytoplasm; protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IPR000682; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) PCMT1 QnpA-11118 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR42511_c0_g2_i11 Q15811 ITSN1_HUMAN 3.00E-06 GO:0005089; GO:0097190; GO:0005509; GO:0030054; GO:0005905; GO:0005829; GO:0030139; GO:0005085; GO:0019209; GO:0030027; GO:0043524; GO:0043005; GO:0048011; GO:0005543; GO:0005886; GO:0043065; GO:0051897; GO:0032947; GO:0035023; GO:0051056; GO:0007264; GO:0045202; GO:0048488 P22681; P60953-1; Q9NRI5; P50570; Q3UQN2; O15357; Q925Q9 Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; calcium ion binding; cell junction; coated pit; cytosol; endocytic vesicle; guanyl-nucleotide exchange factor activity; kinase activator activity; lamellipodium; negative regulation of neuron apoptotic process; neuron projection; neurotrophin TRK receptor signaling pathway; phospholipid binding; plasma membrane; positive regulation of apoptotic process; positive regulation of protein kinase B signaling cascade; protein complex scaffold; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; synapse; synaptic vesicle endocytosis IPR000008; IPR000219; IPR011992; IPR018247; IPR002048; IPR000261; IPR001331; IPR000108; IPR011993; IPR001849; IPR001452; Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) ITSN1 ITSN SH3D1A Homo sapiens (Human) TR42511_c0_g2_i4 Q5FVW6 SKAP2_XENTR 7.00E-17 GO:0042113; GO:0005737; GO:0005543 B cell activation; cytoplasm; phospholipid binding IPR011993; IPR001849; IPR001452; Src kinase-associated phosphoprotein 2 skap2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42511_c0_g2_i8 Q5U597 SKA2B_XENLA 1.00E-18 GO:0042113; GO:0005737; GO:0005543 B cell activation; cytoplasm; phospholipid binding IPR011993; IPR001849; IPR001452; Src kinase-associated phosphoprotein 2-B skap2-b Xenopus laevis (African clawed frog) TR42512_c2_g3_i1 Q62210 BIRC2_MOUSE 3.00E-29 GO:0035631; GO:0006915; GO:0005737; GO:0009898; GO:0070266; GO:0060546; GO:1902443; GO:0005634; GO:0001890; GO:0043123; GO:0043161; GO:0070936; GO:0070534; GO:0042981; GO:0051726; GO:2000377; GO:0006355; GO:0003713; GO:0006351; GO:0004842; GO:0008270 "CD40 receptor complex; apoptotic process; cytoplasm; internal side of plasma membrane; necroptosis; negative regulation of necroptosis; negative regulation of ripoptosome assembly involved in necroptosis; nucleus; placenta development; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; protein K63-linked ubiquitination; regulation of apoptotic process; regulation of cell cycle; regulation of reactive oxygen species metabolic process; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (Inhibitor of apoptosis protein 2) (IAP-2) (mIAP-2) (mIAP2) Birc2 Birc3 Iap2 Mus musculus (Mouse) TR42512_c2_g3_i2 Q60989 XIAP_MOUSE 2.00E-41 GO:0016055; GO:0005737; GO:0005829; GO:1990001; GO:0043066; GO:0043524; GO:0051402; GO:0005634; GO:0048471; GO:0043234; GO:0004842; GO:0008270 P53702; Q9JIY5 Wnt receptor signaling pathway; cytoplasm; cytosol; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of neuron apoptotic process; neuron apoptotic process; nucleus; perinuclear region of cytoplasm; protein complex; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (mIAP-3) (mIAP3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) Xiap Aipa Api3 Birc4 Miha Mus musculus (Mouse) TR42512_c2_g3_i3 A9ULZ2 BIR7B_XENLA 8.00E-38 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) TR42512_c2_g3_i4 P41437 IAP3_NPVOP 2.00E-37 GO:0006915; GO:0016874; GO:0039648; GO:0008270 apoptotic process; ligase activity; modulation by virus of host protein ubiquitination; zinc ion binding IPR001370; IPR001841; IPR013083; E3 ubiquitin-protein ligase IAP-3 (EC 6.3.2.-) (IAP-3) IAP3 IAP ORF35 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) TR42512_c2_g3_i5 Q24306 IAP1_DROME 1.00E-26 GO:0019788; GO:0016055; GO:0048800; GO:0007298; GO:0008407; GO:0004869; GO:0005737; GO:0008354; GO:0097340; GO:1990001; GO:0043066; GO:0046673; GO:0005634; GO:0090263; GO:0031398; GO:0042787; GO:0045035; GO:0007289; GO:0004842; GO:0008270 P25843; Q86PE7; Q9XYF4; Q24475; Q24106 NEDD8 ligase activity; Wnt receptor signaling pathway; antennal morphogenesis; border follicle cell migration; chaeta morphogenesis; cysteine-type endopeptidase inhibitor activity; cytoplasm; germ cell migration; inhibition of cysteine-type endopeptidase activity; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of compound eye retinal cell programmed cell death; nucleus; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; sensory organ precursor cell division; spermatid nucleus differentiation; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; Apoptosis 1 inhibitor (EC 6.3.2.-) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (dIAP1) (Protein thread) th Iap1 CG12284 Drosophila melanogaster (Fruit fly) TR42512_c2_g3_i7 P41436 IAP_GVCPM 3.00E-42 GO:0006915; GO:0008270 apoptotic process; zinc ion binding IPR001370; IPR001841; Apoptosis inhibitor IAP IAP Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) TR42512_c2_g3_i8 P41436 IAP_GVCPM 8.00E-16 GO:0006915; GO:0008270 apoptotic process; zinc ion binding IPR001370; IPR001841; Apoptosis inhibitor IAP IAP Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) TR42512_c2_g3_i9 A9JTP3 BIRC7_XENTR 3.00E-12 GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0051865; GO:0008270 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; protein autoubiquitination; zinc ion binding IPR001370; IPR001841; Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP) (Embryonic/Egg IAP) (EIAP/XLX) birc7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42513_c1_g1_i16 Q5NVN8 RFOX1_PONAB 6.00E-44 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0000166; GO:0005634; GO:0043484 RNA binding; RNA splicing; cytoplasm; mRNA processing; nucleotide binding; nucleus; regulation of RNA splicing IPR025670; IPR012677; IPR017325; IPR000504; RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) RBFOX1 A2BP1 FOX1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42513_c1_g1_i2 Q0VD23 RFOX3_BOVIN 6.00E-17 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0000166; GO:0005634; GO:0043484 RNA binding; RNA splicing; cytoplasm; mRNA processing; nucleotide binding; nucleus; regulation of RNA splicing IPR025670; IPR012677; IPR017325; IPR000504; RNA binding protein fox-1 homolog 3 (Fox-1 homolog C) RBFOX3 Bos taurus (Bovine) TR42513_c1_g1_i3 Q95KI0 RFOX1_MACFA 9.00E-41 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0000166; GO:0005634; GO:0043484 RNA binding; RNA splicing; cytoplasm; mRNA processing; nucleotide binding; nucleus; regulation of RNA splicing IPR025670; IPR012677; IPR017325; IPR000504; RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) RBFOX1 A2BP1 FOX1 QtrA-11594 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR42513_c1_g1_i5 Q5NVN8 RFOX1_PONAB 9.00E-42 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0000166; GO:0005634; GO:0043484 RNA binding; RNA splicing; cytoplasm; mRNA processing; nucleotide binding; nucleus; regulation of RNA splicing IPR025670; IPR012677; IPR017325; IPR000504; RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) RBFOX1 A2BP1 FOX1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42513_c1_g1_i7 Q9JJ43 RFOX1_MOUSE 1.00E-40 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0050885; GO:0005654; GO:0000166; GO:0043484 RNA binding; RNA splicing; cytoplasm; mRNA processing; neuromuscular process controlling balance; nucleoplasm; nucleotide binding; regulation of RNA splicing IPR025670; IPR012677; IPR017325; IPR000504; RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) Rbfox1 A2bp A2bp1 Fox1 MNCb-3035 Mus musculus (Mouse) TR42513_c1_g1_i8 Q0VD23 RFOX3_BOVIN 2.00E-17 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0000166; GO:0005634; GO:0043484 RNA binding; RNA splicing; cytoplasm; mRNA processing; nucleotide binding; nucleus; regulation of RNA splicing IPR025670; IPR012677; IPR017325; IPR000504; RNA binding protein fox-1 homolog 3 (Fox-1 homolog C) RBFOX3 Bos taurus (Bovine) TR42516_c0_g2_i1 Q0VCK5 AP2A2_BOVIN 0 GO:0030122; GO:0048268; GO:0006897; GO:0006886; GO:0008289; GO:0008565 AP-2 adaptor complex; clathrin coat assembly; endocytosis; intracellular protein transport; lipid binding; protein transporter activity IPR017104; IPR011989; IPR016024; IPR002553; IPR013038; IPR003164; IPR008152; IPR015873; IPR009028; IPR013041; AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adapter-related protein complex 2 subunit alpha-2) (Adaptor protein complex AP-2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) AP2A2 Bos taurus (Bovine) TR42516_c0_g2_i3 Q0VCK5 AP2A2_BOVIN 0 GO:0030122; GO:0048268; GO:0006897; GO:0006886; GO:0008289; GO:0008565 AP-2 adaptor complex; clathrin coat assembly; endocytosis; intracellular protein transport; lipid binding; protein transporter activity IPR017104; IPR011989; IPR016024; IPR002553; IPR013038; IPR003164; IPR008152; IPR015873; IPR009028; IPR013041; AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adapter-related protein complex 2 subunit alpha-2) (Adaptor protein complex AP-2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) AP2A2 Bos taurus (Bovine) TR42517_c2_g1_i1 P52948 NUP98_HUMAN 3.00E-93 GO:0006260; GO:0005975; GO:0019221; GO:0005829; GO:0015758; GO:0051028; GO:0007077; GO:0019048; GO:0042405; GO:0031965; GO:0034399; GO:0051292; GO:0044615; GO:0031080; GO:0005654; GO:0042277; GO:0000059; GO:0010827; GO:0044281; GO:0017056; GO:0055085; GO:0005215; GO:0016032 "DNA replication; carbohydrate metabolic process; cytokine-mediated signaling pathway; cytosol; glucose transport; mRNA transport; mitotic nuclear envelope disassembly; modulation by virus of host morphology or physiology; nuclear inclusion body; nuclear membrane; nuclear periphery; nuclear pore complex assembly; nuclear pore nuclear basket; nuclear pore outer ring; nucleoplasm; peptide binding; protein import into nucleus, docking; regulation of glucose transport; small molecule metabolic process; structural constituent of nuclear pore; transmembrane transport; transporter activity; viral process" IPR021967; IPR007230; Nuclear pore complex protein Nup98-Nup96 [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] NUP98 ADAR2 Homo sapiens (Human) TR42518_c1_g1_i10 Q5EAJ7 MVP_STRPU 0 GO:0005737; GO:0005634; GO:0030529 cytoplasm; nucleus; ribonucleoprotein complex IPR000048; IPR021870; IPR002499; Major vault protein (MVP) MVP Strongylocentrotus purpuratus (Purple sea urchin) TR42518_c1_g1_i14 Q5EAJ7 MVP_STRPU 0 GO:0005737; GO:0005634; GO:0030529 cytoplasm; nucleus; ribonucleoprotein complex IPR000048; IPR021870; IPR002499; Major vault protein (MVP) MVP Strongylocentrotus purpuratus (Purple sea urchin) TR42518_c1_g1_i3 Q5EAJ7 MVP_STRPU 0 GO:0005737; GO:0005634; GO:0030529 cytoplasm; nucleus; ribonucleoprotein complex IPR000048; IPR021870; IPR002499; Major vault protein (MVP) MVP Strongylocentrotus purpuratus (Purple sea urchin) TR42518_c1_g1_i9 Q5EAJ7 MVP_STRPU 0 GO:0005737; GO:0005634; GO:0030529 cytoplasm; nucleus; ribonucleoprotein complex IPR000048; IPR021870; IPR002499; Major vault protein (MVP) MVP Strongylocentrotus purpuratus (Purple sea urchin) TR42519_c1_g1_i1 Q7ZU13 SPNS1_DANRE 1.00E-96 GO:0016021; GO:0006869; GO:0005743; GO:0055085 integral to membrane; lipid transport; mitochondrial inner membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Protein spinster homolog 1 (Protein not really started) (Spinster-like protein) spns1 nrs spinl Danio rerio (Zebrafish) (Brachydanio rerio) TR42519_c1_g1_i3 Q9GQQ0 SPIN_DROME 3.00E-95 GO:0009267; GO:0007619; GO:0008333; GO:0010001; GO:0008347; GO:0016021; GO:0035193; GO:0031902; GO:0006869; GO:0005765; GO:0007040; GO:0090099; GO:0045476; GO:0007422; GO:0045924; GO:0045477; GO:0008582; GO:0051124; GO:0048488; GO:0055085; GO:0031982 cellular response to starvation; courtship behavior; endosome to lysosome transport; glial cell differentiation; glial cell migration; integral to membrane; larval central nervous system remodeling; late endosome membrane; lipid transport; lysosomal membrane; lysosome organization; negative regulation of decapentaplegic signaling pathway; nurse cell apoptotic process; peripheral nervous system development; regulation of female receptivity; regulation of nurse cell apoptotic process; regulation of synaptic growth at neuromuscular junction; synaptic growth at neuromuscular junction; synaptic vesicle endocytosis; transmembrane transport; vesicle IPR011701; IPR020846; IPR016196; Protein spinster (Protein benchwarmer) (Protein diphthong) spin bnch CG8428 Drosophila melanogaster (Fruit fly) TR42519_c1_g2_i10 Q7ZU13 SPNS1_DANRE 2.00E-49 GO:0016021; GO:0006869; GO:0005743; GO:0055085 integral to membrane; lipid transport; mitochondrial inner membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Protein spinster homolog 1 (Protein not really started) (Spinster-like protein) spns1 nrs spinl Danio rerio (Zebrafish) (Brachydanio rerio) TR42519_c1_g2_i12 Q5XGK0 SPNS1_XENLA 2.00E-58 GO:0016021; GO:0006869; GO:0005743; GO:0055085 integral to membrane; lipid transport; mitochondrial inner membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Protein spinster homolog 1 spns1 Xenopus laevis (African clawed frog) TR42519_c1_g2_i13 Q5XGK0 SPNS1_XENLA 1.00E-58 GO:0016021; GO:0006869; GO:0005743; GO:0055085 integral to membrane; lipid transport; mitochondrial inner membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Protein spinster homolog 1 spns1 Xenopus laevis (African clawed frog) TR42520_c0_g1_i1 Q0VGE8 ZN816_HUMAN 8.00E-06 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 816 ZNF816 ZNF816A Homo sapiens (Human) TR42520_c0_g2_i1 Q8K1S5 KLF11_MOUSE 5.00E-07 GO:0003677; GO:0006915; GO:0046872; GO:0008285; GO:0000122; GO:0045892; GO:0005634; GO:0043065; GO:0000981; GO:0003700; GO:0006366; GO:0044212 "DNA binding; apoptotic process; metal ion binding; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of apoptotic process; sequence-specific DNA binding RNA polymerase II transcription factor activity; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; transcription regulatory region DNA binding" IPR007087; IPR015880; IPR013087; Krueppel-like factor 11 (TGFB-inducible early growth response protein 2b) (Transforming growth factor-beta-inducible early growth response protein 3) (TGFB-inducible early growth response protein 3) (TIEG-3) Klf11 Tieg2b Tieg3 Mus musculus (Mouse) TR42520_c1_g1_i1 Q5ZIL4 STRBP_CHICK 8.00E-14 GO:0003677; GO:0003723; GO:0030154; GO:0005737; GO:0007275; GO:0005634; GO:0007283 DNA binding; RNA binding; cell differentiation; cytoplasm; multicellular organismal development; nucleus; spermatogenesis IPR014720; IPR006561; Spermatid perinuclear RNA-binding protein STRBP RCJMB04_25e3 Gallus gallus (Chicken) TR42520_c1_g1_i2 Q12906 ILF3_HUMAN 2.00E-12 GO:0003677; GO:0000279; GO:0051607; GO:0003725; GO:0005739; GO:0045892; GO:0017148; GO:0045071; GO:0005730; GO:0005634; GO:0045893; GO:0006468; GO:0030529; GO:0006351 Q99873 "DNA binding; M phase; defense response to virus; double-stranded RNA binding; mitochondrion; negative regulation of transcription, DNA-dependent; negative regulation of translation; negative regulation of viral genome replication; nucleolus; nucleus; positive regulation of transcription, DNA-dependent; protein phosphorylation; ribonucleoprotein complex; transcription, DNA-dependent" IPR014720; IPR006561; Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) ILF3 DRBF MPHOSPH4 NF90 Homo sapiens (Human) TR42520_c1_g2_i1 P51400 RED1_RAT 1.00E-92 GO:0006396; GO:0006382; GO:0003726; GO:0003725; GO:0016556; GO:0006397; GO:0046872; GO:0030336; GO:0008285; GO:0044387; GO:0005730; GO:0005654; GO:0045070; GO:0051726 RNA processing; adenosine to inosine editing; double-stranded RNA adenosine deaminase activity; double-stranded RNA binding; mRNA modification; mRNA processing; metal ion binding; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of protein kinase activity by regulation of protein phosphorylation; nucleolus; nucleoplasm; positive regulation of viral genome replication; regulation of cell cycle IPR002466; IPR014720; Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) Adarb1 Red1 Rattus norvegicus (Rat) TR42520_c1_g5_i2 P78563 RED1_HUMAN 5.00E-86 GO:0003723; GO:0006396; GO:0004000; GO:0006382; GO:0016553; GO:0051607; GO:0003726; GO:0003725; GO:0010467; GO:0045087; GO:0003729; GO:0016556; GO:0006397; GO:0046872; GO:0030336; GO:0008285; GO:0044387; GO:0005730; GO:0005654; GO:0005634; GO:0045070; GO:0051726 Q13526; O00308 RNA binding; RNA processing; adenosine deaminase activity; adenosine to inosine editing; base conversion or substitution editing; defense response to virus; double-stranded RNA adenosine deaminase activity; double-stranded RNA binding; gene expression; innate immune response; mRNA binding; mRNA modification; mRNA processing; metal ion binding; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of protein kinase activity by regulation of protein phosphorylation; nucleolus; nucleoplasm; nucleus; positive regulation of viral genome replication; regulation of cell cycle IPR002466; IPR008996; IPR014720; Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) ADARB1 ADAR2 DRADA2 RED1 Homo sapiens (Human) TR42520_c1_g5_i3 Q9NS39 RED2_HUMAN 3.00E-73 GO:0004000; GO:0003725; GO:0006397; GO:0046872; GO:0005739; GO:0005634; GO:0003727 adenosine deaminase activity; double-stranded RNA binding; mRNA processing; metal ion binding; mitochondrion; nucleus; single-stranded RNA binding IPR002466; IPR014720; Double-stranded RNA-specific editase B2 (EC 3.5.-.-) (RNA-dependent adenosine deaminase 3) (RNA-editing deaminase 2) (RNA-editing enzyme 2) (dsRNA adenosine deaminase B2) ADARB2 ADAR3 RED2 Homo sapiens (Human) TR42522_c1_g1_i1 Q47329 UDG5_ECOLX 1.00E-26 GO:0051287; GO:0003979; GO:0006065; GO:0045227 NAD binding; UDP-glucose 6-dehydrogenase activity; UDP-glucuronate biosynthetic process; capsule polysaccharide biosynthetic process IPR008927; IPR013328; IPR016040; IPR017476; IPR014027; IPR014026; IPR001732; IPR028357; Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1. Capsule biogenesis; capsule polysaccharide biosynthesis. UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) kfiD Escherichia coli TR42522_c1_g1_i2 O02373 UGDH_DROME 0 GO:0051287; GO:0003979; GO:0006065; GO:0016055; GO:0030206; GO:0007427; GO:0008543; GO:0007507; GO:0015014; GO:0007476; GO:0002121; GO:0007509; GO:0016319; GO:0042048; GO:0007428; GO:0007367; GO:0007224 "NAD binding; UDP-glucose 6-dehydrogenase activity; UDP-glucuronate biosynthetic process; Wnt receptor signaling pathway; chondroitin sulfate biosynthetic process; epithelial cell migration, open tracheal system; fibroblast growth factor receptor signaling pathway; heart development; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; imaginal disc-derived wing morphogenesis; inter-male aggressive behavior; mesoderm migration involved in gastrulation; mushroom body development; olfactory behavior; primary branching, open tracheal system; segment polarity determination; smoothened signaling pathway" IPR008927; IPR016040; IPR017476; IPR014027; IPR014026; IPR001732; IPR028356; Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1. UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) (Protein sugarless) (Protein suppenkasper) sgl kiwi ska CG10072 Drosophila melanogaster (Fruit fly) TR42522_c1_g1_i4 O02373 UGDH_DROME 0 GO:0051287; GO:0003979; GO:0006065; GO:0016055; GO:0030206; GO:0007427; GO:0008543; GO:0007507; GO:0015014; GO:0007476; GO:0002121; GO:0007509; GO:0016319; GO:0042048; GO:0007428; GO:0007367; GO:0007224 "NAD binding; UDP-glucose 6-dehydrogenase activity; UDP-glucuronate biosynthetic process; Wnt receptor signaling pathway; chondroitin sulfate biosynthetic process; epithelial cell migration, open tracheal system; fibroblast growth factor receptor signaling pathway; heart development; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; imaginal disc-derived wing morphogenesis; inter-male aggressive behavior; mesoderm migration involved in gastrulation; mushroom body development; olfactory behavior; primary branching, open tracheal system; segment polarity determination; smoothened signaling pathway" IPR008927; IPR016040; IPR017476; IPR014027; IPR014026; IPR001732; IPR028356; Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1. UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) (Protein sugarless) (Protein suppenkasper) sgl kiwi ska CG10072 Drosophila melanogaster (Fruit fly) TR42522_c1_g1_i5 Q19905 UGDH_CAEEL 0 GO:0051287; GO:0003979; GO:0006065; GO:0005737; GO:0009792; GO:0006024; GO:0002009; GO:0018991; GO:0040025 Itself NAD binding; UDP-glucose 6-dehydrogenase activity; UDP-glucuronate biosynthetic process; cytoplasm; embryo development ending in birth or egg hatching; glycosaminoglycan biosynthetic process; morphogenesis of an epithelium; oviposition; vulval development IPR008927; IPR016040; IPR017476; IPR014027; IPR014026; IPR001732; IPR028356; Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1. UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) (Squashed vulva protein 4) sqv-4 F29F11.1 Caenorhabditis elegans TR42523_c2_g1_i1 Q29HY3 CDC42_DROPS 5.00E-111 GO:0005525; GO:0005912; GO:0005622; GO:0045185; GO:0007275; GO:0005886; GO:0045860; GO:0007264 GTP binding; adherens junction; intracellular; maintenance of protein location; multicellular organismal development; plasma membrane; positive regulation of protein kinase activity; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Cdc42 homolog Cdc42 GA11680 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR42523_c2_g1_i2 P53879 RHO5_YEAST 4.00E-55 GO:0005525; GO:0003924; GO:0007266; GO:0012505; GO:0000329; GO:0005886 GTP binding; GTPase activity; Rho protein signal transduction; endomembrane system; fungal-type vacuole membrane; plasma membrane IPR027417; IPR005225; IPR001806; IPR003578; GTP-binding protein RHO5 RHO5 YNL180C N1644 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42523_c2_g1_i3 P22122 RHO_DISOM 8.00E-55 GO:0005525; GO:0005622; GO:0005886; GO:0007264 GTP binding; intracellular; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Ras-like GTP-binding protein O-RHO Diplobatis ommata (Ocellated electric ray) (Discopyge ommata) TR42523_c2_g1_i4 Q29HY3 CDC42_DROPS 2.00E-111 GO:0005525; GO:0005912; GO:0005622; GO:0045185; GO:0007275; GO:0005886; GO:0045860; GO:0007264 GTP binding; adherens junction; intracellular; maintenance of protein location; multicellular organismal development; plasma membrane; positive regulation of protein kinase activity; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Cdc42 homolog Cdc42 GA11680 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR42523_c2_g1_i5 Q17031 CDC42_ANOGA 2.00E-110 GO:0005525; GO:0005912; GO:0005622; GO:0007275; GO:0005886; GO:0007264 GTP binding; adherens junction; intracellular; multicellular organismal development; plasma membrane; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Cdc42 homolog (25 kDa GTP-binding protein) Cdc42 AGAP002440 Anopheles gambiae (African malaria mosquito) TR42523_c2_g1_i6 Q29HY3 CDC42_DROPS 6.00E-111 GO:0005525; GO:0005912; GO:0005622; GO:0045185; GO:0007275; GO:0005886; GO:0045860; GO:0007264 GTP binding; adherens junction; intracellular; maintenance of protein location; multicellular organismal development; plasma membrane; positive regulation of protein kinase activity; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Cdc42 homolog Cdc42 GA11680 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR42524_c2_g2_i1 Q04861 NFKB1_CHICK 4.00E-19 GO:0002755; GO:0051059; GO:0035419; GO:0007250; GO:0005829; GO:0045087; GO:0001818; GO:0050728; GO:0045083; GO:0045892; GO:0005634; GO:0045944; GO:0043565; GO:0003700; GO:0035681; GO:0034134; GO:0035682; GO:0034138; GO:0034142; GO:0034146; GO:0034154; GO:0006351 "MyD88-dependent toll-like receptor signaling pathway; NF-kappaB binding; activation of MAPK activity involved in innate immune response; activation of NF-kappaB-inducing kinase activity; cytosol; innate immune response; negative regulation of cytokine production; negative regulation of inflammatory response; negative regulation of interleukin-12 biosynthetic process; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; toll-like receptor 15 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 21 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 7 signaling pathway; transcription, DNA-dependent" IPR002110; IPR020683; IPR011029; IPR000488; IPR013783; IPR014756; IPR002909; IPR000451; IPR008967; IPR011539; Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] NFKB1 Gallus gallus (Chicken) TR42524_c2_g2_i2 Q04861 NFKB1_CHICK 4.00E-19 GO:0002755; GO:0051059; GO:0035419; GO:0007250; GO:0005829; GO:0045087; GO:0001818; GO:0050728; GO:0045083; GO:0045892; GO:0005634; GO:0045944; GO:0043565; GO:0003700; GO:0035681; GO:0034134; GO:0035682; GO:0034138; GO:0034142; GO:0034146; GO:0034154; GO:0006351 "MyD88-dependent toll-like receptor signaling pathway; NF-kappaB binding; activation of MAPK activity involved in innate immune response; activation of NF-kappaB-inducing kinase activity; cytosol; innate immune response; negative regulation of cytokine production; negative regulation of inflammatory response; negative regulation of interleukin-12 biosynthetic process; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; toll-like receptor 15 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 21 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 7 signaling pathway; transcription, DNA-dependent" IPR002110; IPR020683; IPR011029; IPR000488; IPR013783; IPR014756; IPR002909; IPR000451; IPR008967; IPR011539; Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] NFKB1 Gallus gallus (Chicken) TR42525_c1_g1_i1 A2CI35 DUSTY_STRPU 1.00E-82 GO:0005524; GO:0005737; GO:0018108; GO:0004674; GO:0004712; GO:0004713 ATP binding; cytoplasm; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (Receptor-interacting serine/threonine-protein kinase 5) DSTYK RIPK5 Strongylocentrotus purpuratus (Purple sea urchin) TR42525_c2_g4_i1 Q96J92 WNK4_HUMAN 3.00E-50 GO:0005524; GO:0006821; GO:0005737; GO:0072156; GO:0007243; GO:0050801; GO:0090188; GO:0008104; GO:0004674; GO:0070294; GO:0005923 O95747 ATP binding; chloride transport; cytoplasm; distal tubule morphogenesis; intracellular protein kinase cascade; ion homeostasis; negative regulation of pancreatic juice secretion; protein localization; protein serine/threonine kinase activity; renal sodium ion absorption; tight junction IPR011009; IPR024678; IPR000719; IPR008271; Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) WNK4 PRKWNK4 Homo sapiens (Human) TR42525_c2_g4_i2 Q80XP9 WNK3_MOUSE 1.00E-63 GO:0005524; GO:0005912; GO:0005737; GO:0090004; GO:0010800; GO:2000688; GO:2000682; GO:2000651; GO:0010765; GO:0046777; GO:0004672; GO:0004674; GO:0005923 ATP binding; adherens junction; cytoplasm; positive regulation of establishment of protein localization to plasma membrane; positive regulation of peptidyl-threonine phosphorylation; positive regulation of rubidium ion transmembrane transporter activity; positive regulation of rubidium ion transport; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; protein autophosphorylation; protein kinase activity; protein serine/threonine kinase activity; tight junction IPR011009; IPR024678; IPR000719; IPR002290; IPR008271; Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) Wnk3 Mus musculus (Mouse) TR42525_c2_g5_i1 Q6XUX2 DUSTY_RAT 8.00E-86 GO:0005524; GO:0005737; GO:0045111; GO:0005634; GO:0018108; GO:0004674; GO:0004712; GO:0004713 ATP binding; cytoplasm; intermediate filament cytoskeleton; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (Receptor-interacting serine/threonine-protein kinase 5) Dstyk Ripk5 Rattus norvegicus (Rat) TR42527_c4_g1_i3 Q96RW7 HMCN1_HUMAN 3.00E-49 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR42527_c4_g1_i6 Q8IZJ1 UNC5B_HUMAN 5.00E-15 GO:0033564; GO:0006915; GO:0007411; GO:0016021; GO:2001240; GO:0043065; GO:0007165 Q8CGU4 anterior/posterior axon guidance; apoptotic process; axon guidance; integral to membrane; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of apoptotic process; signal transduction IPR011029; IPR000488; IPR007110; IPR013783; IPR013098; IPR003598; IPR000884; IPR000906; Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) UNC5B P53RDL1 UNC5H2 UNQ1883/PRO4326 Homo sapiens (Human) TR42527_c4_g1_i7 P35448 TSP1_XENLA 1.00E-23 GO:0005509; GO:0007155; GO:0005576; GO:0008201; GO:0016529 calcium ion binding; cell adhesion; extracellular region; heparin binding; sarcoplasmic reticulum IPR026823; IPR008985; IPR013320; IPR000742; IPR013032; IPR024731; IPR001791; IPR000884; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-1 thbs1 tsp1 Xenopus laevis (African clawed frog) TR42529_c0_g1_i1 Q16787 LAMA3_HUMAN 2.00E-168 GO:0005604; GO:0007155; GO:0008544; GO:0030198; GO:0031581; GO:0005606; GO:0005610; GO:0030155; GO:0030334; GO:0045995; GO:0005198 basement membrane; cell adhesion; epidermis development; extracellular matrix organization; hemidesmosome assembly; laminin-1 complex; laminin-5 complex; regulation of cell adhesion; regulation of cell migration; regulation of embryonic development; structural molecule activity IPR008985; IPR013320; IPR013032; IPR002049; IPR018031; IPR000034; IPR001791; IPR009254; IPR010307; IPR008211; Laminin subunit alpha-3 (Epiligrin 170 kDa subunit) (E170) (Epiligrin subunit alpha) (Kalinin subunit alpha) (Laminin-5 subunit alpha) (Laminin-6 subunit alpha) (Laminin-7 subunit alpha) (Nicein subunit alpha) LAMA3 LAMNA Homo sapiens (Human) TR42529_c0_g2_i1 Q00174 LAMA_DROME 0 GO:0030424; GO:0007411; GO:0005605; GO:0048854; GO:0007155; GO:0030054; GO:0035001; GO:0016321; GO:0007507; GO:0007476; GO:0002121; GO:0005606; GO:0031987; GO:0035011; GO:0007498; GO:0045886; GO:0036062; GO:0030155; GO:0030334; GO:0045995; GO:0001964; GO:0008021 "axon; axon guidance; basal lamina; brain morphogenesis; cell adhesion; cell junction; dorsal trunk growth, open tracheal system; female meiosis chromosome segregation; heart development; imaginal disc-derived wing morphogenesis; inter-male aggressive behavior; laminin-1 complex; locomotion involved in locomotory behavior; melanotic encapsulation of foreign target; mesoderm development; negative regulation of synaptic growth at neuromuscular junction; presynaptic periactive zone; regulation of cell adhesion; regulation of cell migration; regulation of embryonic development; startle response; synaptic vesicle" IPR008985; IPR013320; IPR013032; IPR002049; IPR018031; IPR000034; IPR001791; IPR009254; IPR010307; IPR008211; Laminin subunit alpha (Laminin A chain) LanA lamA CG10236 Drosophila melanogaster (Fruit fly) TR42529_c0_g2_i2 Q00174 LAMA_DROME 0 GO:0030424; GO:0007411; GO:0005605; GO:0048854; GO:0007155; GO:0030054; GO:0035001; GO:0016321; GO:0007507; GO:0007476; GO:0002121; GO:0005606; GO:0031987; GO:0035011; GO:0007498; GO:0045886; GO:0036062; GO:0030155; GO:0030334; GO:0045995; GO:0001964; GO:0008021 "axon; axon guidance; basal lamina; brain morphogenesis; cell adhesion; cell junction; dorsal trunk growth, open tracheal system; female meiosis chromosome segregation; heart development; imaginal disc-derived wing morphogenesis; inter-male aggressive behavior; laminin-1 complex; locomotion involved in locomotory behavior; melanotic encapsulation of foreign target; mesoderm development; negative regulation of synaptic growth at neuromuscular junction; presynaptic periactive zone; regulation of cell adhesion; regulation of cell migration; regulation of embryonic development; startle response; synaptic vesicle" IPR008985; IPR013320; IPR013032; IPR002049; IPR018031; IPR000034; IPR001791; IPR009254; IPR010307; IPR008211; Laminin subunit alpha (Laminin A chain) LanA lamA CG10236 Drosophila melanogaster (Fruit fly) TR42529_c0_g2_i3 Q16787 LAMA3_HUMAN 2.00E-09 GO:0005604; GO:0007155; GO:0008544; GO:0030198; GO:0031581; GO:0005606; GO:0005610; GO:0030155; GO:0030334; GO:0045995; GO:0005198 basement membrane; cell adhesion; epidermis development; extracellular matrix organization; hemidesmosome assembly; laminin-1 complex; laminin-5 complex; regulation of cell adhesion; regulation of cell migration; regulation of embryonic development; structural molecule activity IPR008985; IPR013320; IPR013032; IPR002049; IPR018031; IPR000034; IPR001791; IPR009254; IPR010307; IPR008211; Laminin subunit alpha-3 (Epiligrin 170 kDa subunit) (E170) (Epiligrin subunit alpha) (Kalinin subunit alpha) (Laminin-5 subunit alpha) (Laminin-6 subunit alpha) (Laminin-7 subunit alpha) (Nicein subunit alpha) LAMA3 LAMNA Homo sapiens (Human) TR42530_c1_g2_i1 Q91738 FAK1_XENLA 0 GO:0005524; GO:0005856; GO:0005925; GO:0007275; GO:0004715; GO:0018108; GO:0005886; GO:0007172; GO:0004871; GO:0007165 ATP binding; cytoskeleton; focal adhesion; multicellular organismal development; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation; plasma membrane; signal complex assembly; signal transducer activity; signal transduction IPR019749; IPR014352; IPR019748; IPR000299; IPR005189; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Protein-tyrosine kinase 2) (pp125FAK) ptk2 fak1 Xenopus laevis (African clawed frog) TR42530_c1_g2_i2 Q91738 FAK1_XENLA 0 GO:0005524; GO:0005856; GO:0005925; GO:0007275; GO:0004715; GO:0018108; GO:0005886; GO:0007172; GO:0004871; GO:0007165 ATP binding; cytoskeleton; focal adhesion; multicellular organismal development; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation; plasma membrane; signal complex assembly; signal transducer activity; signal transduction IPR019749; IPR014352; IPR019748; IPR000299; IPR005189; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Protein-tyrosine kinase 2) (pp125FAK) ptk2 fak1 Xenopus laevis (African clawed frog) TR42530_c1_g2_i3 Q9TTY2 FER_CANFA 6.00E-71 GO:0005524; GO:0005938; GO:0030054; GO:0042995; GO:0005856; GO:0008289; GO:0004715; GO:0005634; GO:0005886 ATP binding; cell cortex; cell junction; cell projection; cytoskeleton; lipid binding; non-membrane spanning protein tyrosine kinase activity; nucleus; plasma membrane IPR001060; IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR008266; IPR020635; IPR016250; Tyrosine-protein kinase Fer (EC 2.7.10.2) (Proto-oncogene c-Fer) (p94-Fer) FER Canis familiaris (Dog) (Canis lupus familiaris) TR42530_c1_g2_i6 P10447 ABL_FSVHY 2.00E-69 GO:0005524; GO:0004715; GO:0018108 ATP binding; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase transforming protein Abl (EC 2.7.10.2) (V-abl) ABL Feline sarcoma virus (strain Hardy-Zuckerman 2) TR42530_c1_g2_i7 P42689 SRK3_SPOLA 2.00E-69 GO:0005524; GO:0005737; GO:0004715; GO:0018108 ATP binding; cytoplasm; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR008266; IPR020635; Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment) SRK3 Spongilla lacustris (Freshwater sponge) TR42532_c0_g2_i1 O43301 HS12A_HUMAN 8.00E-44 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR42532_c0_g4_i4 O43301 HS12A_HUMAN 1.00E-11 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR42532_c1_g1_i1 Q96MM6 HS12B_HUMAN 2.00E-14 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR42533_c3_g1_i1 Q96DM1 PGBD4_HUMAN 2.00E-17 PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) TR42534_c2_g1_i1 Q6PB03 PLD3_XENLA 2.00E-119 GO:0070290; GO:0005789; GO:0016021; GO:0016042; GO:0004630 NAPE-specific phospholipase D activity; endoplasmic reticulum membrane; integral to membrane; lipid catabolic process; phospholipase D activity IPR001736; Phospholipase D3 (PLD 3) (EC 3.1.4.4) (Choline phosphatase 3) (Phosphatidylcholine-hydrolyzing phospholipase D3) pld3 Xenopus laevis (African clawed frog) TR42535_c0_g1_i1 P35953 VLDLR_RABIT 2.00E-16 GO:0005509; GO:0008203; GO:0005905; GO:0034436; GO:0034437; GO:0016021; GO:0006869; GO:0000122; GO:1900006; GO:0038025; GO:0021517; GO:0034361; GO:0034189; GO:0034447; GO:0030229 calcium ion binding; cholesterol metabolic process; coated pit; glycoprotein transport; glycoprotein transporter activity; integral to membrane; lipid transport; negative regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite development; reelin receptor activity; ventral spinal cord development; very-low-density lipoprotein particle; very-low-density lipoprotein particle binding; very-low-density lipoprotein particle clearance; very-low-density lipoprotein particle receptor activity IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) VLDLR Oryctolagus cuniculus (Rabbit) TR42535_c0_g1_i10 Q8IWY4 SCUB1_HUMAN 1.00E-29 GO:0007512; GO:0007596; GO:0005509; GO:0045446; GO:0009897; GO:0005615; GO:0019897; GO:0042802; GO:0006954; GO:0009791; GO:0046982; GO:0051260 adult heart development; blood coagulation; calcium ion binding; endothelial cell differentiation; external side of plasma membrane; extracellular space; extrinsic to plasma membrane; identical protein binding; inflammatory response; post-embryonic development; protein heterodimerization activity; protein homooligomerization IPR026823; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR009030; IPR011641; "Signal peptide, CUB and EGF-like domain-containing protein 1" SCUBE1 Homo sapiens (Human) TR42535_c0_g1_i11 Q14517 FAT1_HUMAN 1.00E-07 GO:0007015; GO:0009653; GO:0005509; GO:0016477; GO:0016337; GO:0005911; GO:0007267; GO:0007163; GO:0030175; GO:0007156; GO:0005887; GO:0030027; GO:0005634; GO:0048471 Q8N8S7; Q9NSC5; Q99JP6 actin filament organization; anatomical structure morphogenesis; calcium ion binding; cell migration; cell-cell adhesion; cell-cell junction; cell-cell signaling; establishment or maintenance of cell polarity; filopodium; homophilic cell adhesion; integral to plasma membrane; lamellipodium; nucleus; perinuclear region of cytoplasm IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) TR42535_c0_g1_i12 Q9NQ36 SCUB2_HUMAN 2.00E-28 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR026823; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR011641; "Signal peptide, CUB and EGF-like domain-containing protein 2 (Protein CEGP1)" SCUBE2 CEGP1 Homo sapiens (Human) TR42535_c0_g1_i2 P25723 TLD_DROME 3.00E-07 GO:0007378; GO:0005509; GO:0005576; GO:0008586; GO:0007313; GO:0004222; GO:0010629; GO:0030513; GO:0016485; GO:0006508; GO:0017015; GO:0007362; GO:0008293; GO:0008270 "amnioserosa formation; calcium ion binding; extracellular region; imaginal disc-derived wing vein morphogenesis; maternal specification of dorsal/ventral axis, oocyte, soma encoded; metalloendopeptidase activity; negative regulation of gene expression; positive regulation of BMP signaling pathway; protein processing; proteolysis; regulation of transforming growth factor beta receptor signaling pathway; terminal region determination; torso signaling pathway; zinc ion binding" IPR015446; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024079; IPR001506; IPR006026; Dorsal-ventral patterning protein tolloid (EC 3.4.24.-) tld CG6868 Drosophila melanogaster (Fruit fly) TR42535_c0_g1_i3 Q8IWY4 SCUB1_HUMAN 2.00E-30 GO:0007512; GO:0007596; GO:0005509; GO:0045446; GO:0009897; GO:0005615; GO:0019897; GO:0042802; GO:0006954; GO:0009791; GO:0046982; GO:0051260 adult heart development; blood coagulation; calcium ion binding; endothelial cell differentiation; external side of plasma membrane; extracellular space; extrinsic to plasma membrane; identical protein binding; inflammatory response; post-embryonic development; protein heterodimerization activity; protein homooligomerization IPR026823; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR009030; IPR011641; "Signal peptide, CUB and EGF-like domain-containing protein 1" SCUBE1 Homo sapiens (Human) TR42535_c0_g1_i5 Q6UXH8 CCBE1_HUMAN 5.00E-09 GO:0005509; GO:0005581; GO:0005518; GO:0031012; GO:0001946; GO:0002040; GO:0048845 calcium ion binding; collagen; collagen binding; extracellular matrix; lymphangiogenesis; sprouting angiogenesis; venous blood vessel morphogenesis IPR008160; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; Collagen and calcium-binding EGF domain-containing protein 1 (Full of fluid protein homolog) CCBE1 KIAA1983 UNQ1921/PRO4395 Homo sapiens (Human) TR42535_c0_g1_i6 O00339 MATN2_HUMAN 4.00E-26 GO:0007411; GO:0005604; GO:0005509; GO:0031104; GO:0008347; GO:0001764; GO:0005578; GO:0048678 O15265; O00555 axon guidance; basement membrane; calcium ion binding; dendrite regeneration; glial cell migration; neuron migration; proteinaceous extracellular matrix; response to axon injury IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR009030; IPR019466; IPR002035; Matrilin-2 MATN2 UNQ193/PRO219 Homo sapiens (Human) TR42535_c0_g1_i7 Q29RU2 OIT3_BOVIN 5.00E-14 GO:0005509; GO:0005635 calcium ion binding; nuclear envelope IPR000742; IPR000152; IPR018097; IPR009030; IPR001507; Oncoprotein-induced transcript 3 protein OIT3 Bos taurus (Bovine) TR42535_c0_g1_i8 Q8IWY4 SCUB1_HUMAN 3.00E-29 GO:0007512; GO:0007596; GO:0005509; GO:0045446; GO:0009897; GO:0005615; GO:0019897; GO:0042802; GO:0006954; GO:0009791; GO:0046982; GO:0051260 adult heart development; blood coagulation; calcium ion binding; endothelial cell differentiation; external side of plasma membrane; extracellular space; extrinsic to plasma membrane; identical protein binding; inflammatory response; post-embryonic development; protein heterodimerization activity; protein homooligomerization IPR026823; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR009030; IPR011641; "Signal peptide, CUB and EGF-like domain-containing protein 1" SCUBE1 Homo sapiens (Human) TR42535_c0_g1_i9 Q29RU2 OIT3_BOVIN 8.00E-14 GO:0005509; GO:0005635 calcium ion binding; nuclear envelope IPR000742; IPR000152; IPR018097; IPR009030; IPR001507; Oncoprotein-induced transcript 3 protein OIT3 Bos taurus (Bovine) TR42536_c0_g1_i2 Q12872 SFSWA_HUMAN 2.00E-34 GO:0003723; GO:0006376; GO:0048025; GO:0005634; GO:0006355; GO:0006351 "RNA binding; mRNA splice site selection; negative regulation of mRNA splicing, via spliceosome; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000061; IPR019147; "Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog)" SFSWAP SFRS8 SWAP Homo sapiens (Human) TR42536_c0_g1_i3 D3ZTQ1 SFSWA_RAT 1.00E-55 GO:0003723; GO:0008380; GO:0006397; GO:0048025; GO:0005634; GO:0006355; GO:0006351 "RNA binding; RNA splicing; mRNA processing; negative regulation of mRNA splicing, via spliceosome; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000061; IPR019147; "Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog)" Sfswap Sfrs8 Srsf8 Swap Rattus norvegicus (Rat) TR42538_c1_g2_i11 Q9WV92 E41L3_MOUSE 6.00E-117 GO:0006915; GO:0005911; GO:0030866; GO:0030865; GO:0005737; GO:0007016; GO:0005856; GO:0019898; GO:0044224; GO:0043217; GO:0048812; GO:0030913; GO:0033270; GO:0005886; GO:0071205; GO:0002175; GO:0072659; GO:0008360; GO:0005200 apoptotic process; cell-cell junction; cortical actin cytoskeleton organization; cortical cytoskeleton organization; cytoplasm; cytoskeletal anchoring at plasma membrane; cytoskeleton; extrinsic to membrane; juxtaparanode region of axon; myelin maintenance; neuron projection morphogenesis; paranodal junction assembly; paranode region of axon; plasma membrane; protein localization to juxtaparanode region of axon; protein localization to paranode region of axon; protein localization to plasma membrane; regulation of cell shape; structural constituent of cytoskeleton IPR008379; IPR019749; IPR019750; IPR021187; IPR000798; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; IPR007477; "Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]" Epb41l3 Dal1 Epb4.1l3 Kiaa0987 Mus musculus (Mouse) TR42538_c1_g2_i4 Q9WV92 E41L3_MOUSE 2.00E-116 GO:0006915; GO:0005911; GO:0030866; GO:0030865; GO:0005737; GO:0007016; GO:0005856; GO:0019898; GO:0044224; GO:0043217; GO:0048812; GO:0030913; GO:0033270; GO:0005886; GO:0071205; GO:0002175; GO:0072659; GO:0008360; GO:0005200 apoptotic process; cell-cell junction; cortical actin cytoskeleton organization; cortical cytoskeleton organization; cytoplasm; cytoskeletal anchoring at plasma membrane; cytoskeleton; extrinsic to membrane; juxtaparanode region of axon; myelin maintenance; neuron projection morphogenesis; paranodal junction assembly; paranode region of axon; plasma membrane; protein localization to juxtaparanode region of axon; protein localization to paranode region of axon; protein localization to plasma membrane; regulation of cell shape; structural constituent of cytoskeleton IPR008379; IPR019749; IPR019750; IPR021187; IPR000798; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; IPR007477; "Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]" Epb41l3 Dal1 Epb4.1l3 Kiaa0987 Mus musculus (Mouse) TR42538_c1_g2_i9 Q9WV92 E41L3_MOUSE 7.00E-117 GO:0006915; GO:0005911; GO:0030866; GO:0030865; GO:0005737; GO:0007016; GO:0005856; GO:0019898; GO:0044224; GO:0043217; GO:0048812; GO:0030913; GO:0033270; GO:0005886; GO:0071205; GO:0002175; GO:0072659; GO:0008360; GO:0005200 apoptotic process; cell-cell junction; cortical actin cytoskeleton organization; cortical cytoskeleton organization; cytoplasm; cytoskeletal anchoring at plasma membrane; cytoskeleton; extrinsic to membrane; juxtaparanode region of axon; myelin maintenance; neuron projection morphogenesis; paranodal junction assembly; paranode region of axon; plasma membrane; protein localization to juxtaparanode region of axon; protein localization to paranode region of axon; protein localization to plasma membrane; regulation of cell shape; structural constituent of cytoskeleton IPR008379; IPR019749; IPR019750; IPR021187; IPR000798; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; IPR007477; "Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]" Epb41l3 Dal1 Epb4.1l3 Kiaa0987 Mus musculus (Mouse) TR42540_c0_g1_i1 Q6AWC2 WWC2_HUMAN 2.00E-118 IPR000008; IPR001202; Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2) WWC2 BOMB Homo sapiens (Human) TR42540_c0_g1_i2 Q5TCQ9 MAGI3_HUMAN 3.00E-13 GO:0005524; GO:0006915; GO:0004385; GO:0035556; GO:0016020; GO:0019048; GO:0005634; GO:0005886; GO:0043507; GO:0005923 P08588; P07550; Q9H204 ATP binding; apoptotic process; guanylate kinase activity; intracellular signal transduction; membrane; modulation by virus of host morphology or physiology; nucleus; plasma membrane; positive regulation of JUN kinase activity; tight junction IPR008145; IPR008144; IPR020590; IPR027417; IPR001478; IPR001202; "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (Membrane-associated guanylate kinase inverted 3) (MAGI-3)" MAGI3 KIAA1634 Homo sapiens (Human) TR42540_c0_g1_i3 Q6AWC2 WWC2_HUMAN 1.00E-120 IPR000008; IPR001202; Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2) WWC2 BOMB Homo sapiens (Human) TR42540_c0_g1_i4 P47191 SYT1_CHICK 2.00E-06 GO:0030054; GO:0042584; GO:0016021; GO:0046872; GO:0030672; GO:0005215 cell junction; chromaffin granule membrane; integral to membrane; metal ion binding; synaptic vesicle membrane; transporter activity IPR000008; IPR001565; IPR015428; Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65) SYT1 Gallus gallus (Chicken) TR42541_c3_g2_i1 Q9C0C9 UBE2O_HUMAN 2.00E-78 GO:0005524; GO:0004842 O35182; O35253 ATP binding; ubiquitin-protein ligase activity IPR000608; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 O (EC 6.3.2.19) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) UBE2O KIAA1734 Homo sapiens (Human) TR42541_c3_g2_i2 P52490 UBC13_YEAST 9.00E-10 GO:0005524; GO:0005737; GO:0010994; GO:0005634; GO:0006301; GO:0006513; GO:0000209; GO:0031371; GO:0004842 P53152 ATP binding; cytoplasm; free ubiquitin chain polymerization; nucleus; postreplication repair; protein monoubiquitination; protein polyubiquitination; ubiquitin conjugating enzyme complex; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 13 (EC 6.3.2.19) (Ubiquitin carrier protein 13) (Ubiquitin-protein ligase 13) UBC13 YDR092W YD6652.04 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42541_c3_g2_i3 Q9ZVX1 UBC23_ARATH 4.00E-50 GO:0005524; GO:0005829; GO:0004842 ATP binding; cytosol; ubiquitin-protein ligase activity IPR000608; IPR016135; Protein modification; protein ubiquitination. Probable ubiquitin-conjugating enzyme E2 23 (EC 6.3.2.19) (Ubiquitin carrier protein 23) UBC23 At2g16920 F12A24.10 Arabidopsis thaliana (Mouse-ear cress) TR42542_c0_g2_i1 Q8N3T6 T132C_HUMAN 4.00E-61 GO:0016021 integral to membrane IPR026307; Transmembrane protein 132C TMEM132C Homo sapiens (Human) TR42542_c0_g2_i3 Q8CEF9 T132C_MOUSE 2.00E-59 GO:0016021; GO:0010923 integral to membrane; negative regulation of phosphatase activity IPR026307; Transmembrane protein 132C Tmem132c Mus musculus (Mouse) TR42543_c0_g4_i1 P15330 DORS_DROME 6.00E-95 GO:0001077; GO:0000977; GO:0008063; GO:0009952; GO:0005737; GO:0009950; GO:0001715; GO:0010004; GO:0008354; GO:0007507; GO:0035006; GO:0007501; GO:0000122; GO:0031594; GO:0005634; GO:0048935; GO:0042387; GO:0006964; GO:0000381; GO:0035206; GO:0007419 Q03017; Q9W1A4; P22812 "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II regulatory region sequence-specific DNA binding; Toll signaling pathway; anterior/posterior pattern specification; cytoplasm; dorsal/ventral axis specification; ectodermal cell fate specification; gastrulation involving germ band extension; germ cell migration; heart development; melanization defense response; mesodermal cell fate specification; negative regulation of transcription from RNA polymerase II promoter; neuromuscular junction; nucleus; peripheral nervous system neuron development; plasmatocyte differentiation; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; regulation of alternative mRNA splicing, via spliceosome; regulation of hemocyte proliferation; ventral cord development" IPR013783; IPR014756; IPR002909; IPR000451; IPR008967; IPR011539; Embryonic polarity protein dorsal dl CG6667 Drosophila melanogaster (Fruit fly) TR42543_c0_g4_i2 P16236 REL_CHICK 3.00E-91 GO:0003677; GO:0006309; GO:0005737; GO:0005634; GO:0046982; GO:0042803; GO:0003700 DNA binding; apoptotic DNA fragmentation; cytoplasm; nucleus; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding transcription factor activity IPR013783; IPR014756; IPR002909; IPR000451; IPR008967; IPR011539; Proto-oncogene c-Rel (p68) REL Gallus gallus (Chicken) TR42545_c1_g1_i2 A7Z063 WASH1_BOVIN 5.00E-85 GO:0034314; GO:0071203; GO:0043014; GO:0005769; GO:0031901; GO:0055037; GO:0055038; GO:0042147 "Arp2/3 complex-mediated actin nucleation; WASH complex; alpha-tubulin binding; early endosome; early endosome membrane; recycling endosome; recycling endosome membrane; retrograde transport, endosome to Golgi" IPR028290; IPR021854; IPR003124; WAS protein family homolog 1 WASH1 Bos taurus (Bovine) TR42545_c2_g1_i2 P43166 CAH7_HUMAN 2.00E-46 GO:0015701; GO:0004089; GO:0005829; GO:0006730; GO:0044281; GO:0008270 bicarbonate transport; carbonate dehydratase activity; cytosol; one-carbon metabolic process; small molecule metabolic process; zinc ion binding IPR001148; IPR023561; IPR018338; IPR018438; Carbonic anhydrase 7 (EC 4.2.1.1) (Carbonate dehydratase VII) (Carbonic anhydrase VII) (CA-VII) CA7 Homo sapiens (Human) TR42545_c3_g2_i1 Q2V2M9 FHOD3_HUMAN 3.00E-115 GO:0030018; GO:0007015; GO:0005737; GO:0005856; GO:0030837; GO:0005730; GO:0045214 Q13501 Z disc; actin filament organization; cytoplasm; cytoskeleton; negative regulation of actin filament polymerization; nucleolus; sarcomere organization IPR016024; IPR014767; IPR015425; IPR027651; IPR014768; FH1/FH2 domain-containing protein 3 (Formactin-2) (Formin homolog overexpressed in spleen 2) (hFHOS2) FHOD3 FHOS2 KIAA1695 Homo sapiens (Human) TR42545_c3_g2_i2 Q2V2M9 FHOD3_HUMAN 4.00E-110 GO:0030018; GO:0007015; GO:0005737; GO:0005856; GO:0030837; GO:0005730; GO:0045214 Q13501 Z disc; actin filament organization; cytoplasm; cytoskeleton; negative regulation of actin filament polymerization; nucleolus; sarcomere organization IPR016024; IPR014767; IPR015425; IPR027651; IPR014768; FH1/FH2 domain-containing protein 3 (Formactin-2) (Formin homolog overexpressed in spleen 2) (hFHOS2) FHOD3 FHOS2 KIAA1695 Homo sapiens (Human) TR42547_c1_g2_i3 Q2QI47 USH2A_MOUSE 2.00E-09 GO:0016324; GO:0005604; GO:0005518; GO:0005737; GO:0035315; GO:0060113; GO:0016021; GO:0048496; GO:0045494; GO:0050896; GO:0007605; GO:0002142; GO:0060171; GO:0007601 apical plasma membrane; basement membrane; collagen binding; cytoplasm; hair cell differentiation; inner ear receptor cell differentiation; integral to membrane; maintenance of organ identity; photoreceptor cell maintenance; response to stimulus; sensory perception of sound; stereocilia ankle link complex; stereocilium membrane; visual perception IPR008985; IPR013320; IPR002049; IPR003961; IPR013783; IPR001791; IPR008211; IPR026915; Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog) Ush2A Gm676 Mus musculus (Mouse) TR42548_c0_g1_i1 Q3MV19 TRF6A_XENLA 8.00E-51 GO:0050852; GO:0007250; GO:0046849; GO:0048468; GO:0005737; GO:0070498; GO:0009887; GO:0001503; GO:0043123; GO:0043507; GO:0031666; GO:0045672; GO:0070534; GO:0051865; GO:0042981; GO:0004871; GO:0004842; GO:0008270 T cell receptor signaling pathway; activation of NF-kappaB-inducing kinase activity; bone remodeling; cell development; cytoplasm; interleukin-1-mediated signaling pathway; organ morphogenesis; ossification; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JUN kinase activity; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of osteoclast differentiation; protein K63-linked ubiquitination; protein autoubiquitination; regulation of apoptotic process; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR012227; IPR008974; IPR027139; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. TNF receptor-associated factor 6-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF6) traf6-a Xenopus laevis (African clawed frog) TR42548_c0_g2_i1 Q9CQ29 RN151_MOUSE 7.00E-09 GO:0030154; GO:0005737; GO:0005634; GO:0007283; GO:0004842; GO:0008270 cell differentiation; cytoplasm; nucleus; spermatogenesis; ubiquitin-protein ligase activity; zinc ion binding IPR013323; IPR008974; IPR001841; IPR013083; IPR017907; IPR013010; IPR001293; RING finger protein 151 Rnf151 Mus musculus (Mouse) TR42548_c0_g2_i11 Q28DL4 TRAF6_XENTR 2.00E-28 GO:0050852; GO:0007250; GO:0046849; GO:0048468; GO:0005737; GO:0070498; GO:0009887; GO:0001503; GO:0043123; GO:0043507; GO:0031666; GO:0045672; GO:0070534; GO:0051865; GO:0042981; GO:0004871; GO:0004842; GO:0008270 T cell receptor signaling pathway; activation of NF-kappaB-inducing kinase activity; bone remodeling; cell development; cytoplasm; interleukin-1-mediated signaling pathway; organ morphogenesis; ossification; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JUN kinase activity; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of osteoclast differentiation; protein K63-linked ubiquitination; protein autoubiquitination; regulation of apoptotic process; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR012227; IPR008974; IPR027139; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. TNF receptor-associated factor 6 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF6) traf6 TNeu045k15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42548_c0_g2_i17 Q28DL4 TRAF6_XENTR 6.00E-29 GO:0050852; GO:0007250; GO:0046849; GO:0048468; GO:0005737; GO:0070498; GO:0009887; GO:0001503; GO:0043123; GO:0043507; GO:0031666; GO:0045672; GO:0070534; GO:0051865; GO:0042981; GO:0004871; GO:0004842; GO:0008270 T cell receptor signaling pathway; activation of NF-kappaB-inducing kinase activity; bone remodeling; cell development; cytoplasm; interleukin-1-mediated signaling pathway; organ morphogenesis; ossification; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JUN kinase activity; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of osteoclast differentiation; protein K63-linked ubiquitination; protein autoubiquitination; regulation of apoptotic process; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR012227; IPR008974; IPR027139; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. TNF receptor-associated factor 6 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF6) traf6 TNeu045k15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42548_c0_g2_i4 Q28DL4 TRAF6_XENTR 7.00E-27 GO:0050852; GO:0007250; GO:0046849; GO:0048468; GO:0005737; GO:0070498; GO:0009887; GO:0001503; GO:0043123; GO:0043507; GO:0031666; GO:0045672; GO:0070534; GO:0051865; GO:0042981; GO:0004871; GO:0004842; GO:0008270 T cell receptor signaling pathway; activation of NF-kappaB-inducing kinase activity; bone remodeling; cell development; cytoplasm; interleukin-1-mediated signaling pathway; organ morphogenesis; ossification; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JUN kinase activity; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of osteoclast differentiation; protein K63-linked ubiquitination; protein autoubiquitination; regulation of apoptotic process; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR002083; IPR012227; IPR008974; IPR027139; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. TNF receptor-associated factor 6 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF6) traf6 TNeu045k15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42549_c2_g2_i1 P78509 RELN_HUMAN 0 GO:0097114; GO:0008306; GO:0007411; GO:0007155; GO:0021800; GO:0005737; GO:0030425; GO:0016358; GO:0005615; GO:0010001; GO:0021766; GO:0007616; GO:0046872; GO:0001764; GO:0018108; GO:0032793; GO:0032008; GO:2000969; GO:0061003; GO:2000463; GO:1900273; GO:0010976; GO:0014068; GO:0061098; GO:0051057; GO:0090129; GO:0051968; GO:0097119; GO:0004712; GO:0005578; GO:0006508; GO:0097120; GO:0038026; GO:2000310; GO:0050795; GO:0048265; GO:0008236; GO:0021511; GO:0021517; GO:0070326 "N-methyl-D-aspartate receptor clustering; associative learning; axon guidance; cell adhesion; cerebral cortex tangential migration; cytoplasm; dendrite; dendrite development; extracellular space; glial cell differentiation; hippocampus development; long-term memory; metal ion binding; neuron migration; peptidyl-tyrosine phosphorylation; positive regulation of CREB transcription factor activity; positive regulation of TOR signaling cascade; positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; positive regulation of dendritic spine morphogenesis; positive regulation of excitatory postsynaptic membrane potential; positive regulation of long-term synaptic potentiation; positive regulation of neuron projection development; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of protein tyrosine kinase activity; positive regulation of small GTPase mediated signal transduction; positive regulation of synapse maturation; positive regulation of synaptic transmission, glutamatergic; postsynaptic density protein 95 clustering; protein serine/threonine/tyrosine kinase activity; proteinaceous extracellular matrix; proteolysis; receptor localization to synapse; reelin-mediated signaling pathway; regulation of N-methyl-D-aspartate selective glutamate receptor activity; regulation of behavior; response to pain; serine-type peptidase activity; spinal cord patterning; ventral spinal cord development; very-low-density lipoprotein particle receptor binding" IPR000742; IPR013032; IPR002861; IPR011040; Reelin (EC 3.4.21.-) RELN Homo sapiens (Human) TR42549_c2_g2_i2 P58751 RELN_RAT 0 GO:0030424; GO:0007411; GO:0007155; GO:0071549; GO:0021800; GO:0005737; GO:0030425; GO:0021542; GO:0005615; GO:0010001; GO:0021854; GO:0007626; GO:0007613; GO:0046872; GO:0007494; GO:0001764; GO:0021769; GO:0018108; GO:0043204; GO:0045860; GO:0051057; GO:0004712; GO:0005578; GO:0006508; GO:0043200; GO:0048678; GO:0051412; GO:0042493; GO:0051602; GO:0045471; GO:0070542; GO:0017085; GO:0010226; GO:0009612; GO:0048265; GO:0032570; GO:0008236; GO:0035176; GO:0021511 axon; axon guidance; cell adhesion; cellular response to dexamethasone stimulus; cerebral cortex tangential migration; cytoplasm; dendrite; dentate gyrus development; extracellular space; glial cell differentiation; hypothalamus development; locomotory behavior; memory; metal ion binding; midgut development; neuron migration; orbitofrontal cortex development; peptidyl-tyrosine phosphorylation; perikaryon; positive regulation of protein kinase activity; positive regulation of small GTPase mediated signal transduction; protein serine/threonine/tyrosine kinase activity; proteinaceous extracellular matrix; proteolysis; response to amino acid stimulus; response to axon injury; response to corticosterone stimulus; response to drug; response to electrical stimulus; response to ethanol; response to fatty acid; response to insecticide; response to lithium ion; response to mechanical stimulus; response to pain; response to progesterone stimulus; serine-type peptidase activity; social behavior; spinal cord patterning IPR000742; IPR013032; IPR002861; IPR011040; Reelin (EC 3.4.21.-) Reln Rattus norvegicus (Rat) TR42550_c3_g1_i1 Q13263 TIF1B_HUMAN 2.00E-07 GO:0003677; GO:0006281; GO:0035851; GO:0060028; GO:0060669; GO:0001837; GO:0000122; GO:0045892; GO:0005719; GO:0005720; GO:0005654; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270 Q13185; P23198; P45973; P43356; P43357; P43360; Q9UBF1; Q9HCI5; O75376 "DNA binding; DNA repair; Krueppel-associated box domain binding; convergent extension involved in axis elongation; embryonic placenta morphogenesis; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nuclear heterochromatin; nucleoplasm; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein kinase activity; protein oligomerization; protein sumoylation; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription corepressor activity; transcription initiation from RNA polymerase II promoter; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein modification; protein sumoylation. Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) TR42551_c0_g2_i3 B1H349 SOX6_XENTR 3.00E-53 GO:0003677; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009071; IPR027153; Transcription factor Sox-6 (SRY (sex determining region Y)-box 6) sox6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42551_c0_g2_i4 B1H349 SOX6_XENTR 1.00E-53 GO:0003677; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009071; IPR027153; Transcription factor Sox-6 (SRY (sex determining region Y)-box 6) sox6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42553_c1_g1_i1 Q8C3X4 GUF1_MOUSE 0 GO:0005525; GO:0006184; GO:0003924; GO:0005743; GO:0005739; GO:0006412 GTP binding; GTP catabolic process; GTPase activity; mitochondrial inner membrane; mitochondrion; translation IPR006297; IPR000795; IPR009022; IPR000640; IPR013842; IPR027417; IPR005225; IPR009000; IPR004161; "Translation factor Guf1, mitochondrial (EC 3.6.5.-) (Elongation factor 4 homolog) (EF-4) (GTPase Guf1) (Ribosomal back-translocase)" Guf1 Mus musculus (Mouse) TR42553_c1_g1_i2 Q38BU9 GUF1_TRYB2 8.00E-52 GO:0005525; GO:0006184; GO:0003924; GO:0005743; GO:0006412 GTP binding; GTP catabolic process; GTPase activity; mitochondrial inner membrane; translation IPR006297; IPR000795; IPR009022; IPR000640; IPR013842; IPR027417; IPR005225; IPR009000; "Translation factor GUF1 homolog, mitochondrial (EC 3.6.5.-) (Elongation factor 4 homolog) (EF-4) (GTPase GUF1 homolog) (Ribosomal back-translocase)" Tb10.70.4600 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) TR42553_c1_g1_i3 Q8C3X4 GUF1_MOUSE 0 GO:0005525; GO:0006184; GO:0003924; GO:0005743; GO:0005739; GO:0006412 GTP binding; GTP catabolic process; GTPase activity; mitochondrial inner membrane; mitochondrion; translation IPR006297; IPR000795; IPR009022; IPR000640; IPR013842; IPR027417; IPR005225; IPR009000; IPR004161; "Translation factor Guf1, mitochondrial (EC 3.6.5.-) (Elongation factor 4 homolog) (EF-4) (GTPase Guf1) (Ribosomal back-translocase)" Guf1 Mus musculus (Mouse) TR42553_c1_g1_i5 O28385 EF2_ARCFU 5.00E-33 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; translation elongation factor activity IPR000795; IPR009022; IPR000640; IPR027417; IPR020568; IPR014721; IPR005225; IPR009000; IPR004543; IPR005517; IPR004161; Elongation factor 2 (EF-2) fusA fus AF_1894 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) TR42555_c1_g1_i2 Q6DBT3 TXD17_DANRE 2.00E-25 GO:0005737 cytoplasm IPR010357; IPR012336; Thioredoxin domain-containing protein 17 (Thioredoxin-like protein 5) txndc17 txnl5 zgc:91920 Danio rerio (Zebrafish) (Brachydanio rerio) TR42555_c2_g3_i2 Q9P544 VDAC_SCHPO 2.00E-38 GO:0005741; GO:0007005; GO:0046930; GO:0015288; GO:0008308 mitochondrial outer membrane; mitochondrion organization; pore complex; porin activity; voltage-gated anion channel activity IPR023614; IPR001925; IPR027246; Probable mitochondrial outer membrane protein porin SPAC1635.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42555_c2_g3_i3 P82013 VDAC2_MELGA 1.00E-135 GO:0005741; GO:0000166; GO:0046930; GO:0015288; GO:0008308 mitochondrial outer membrane; nucleotide binding; pore complex; porin activity; voltage-gated anion channel activity IPR023614; IPR001925; IPR027246; Voltage-dependent anion-selective channel protein 2 (VDAC-2) (Outer mitochondrial membrane protein porin 2) VDAC2 Meleagris gallopavo (Common turkey) TR42556_c2_g4_i1 Q9LDU6 ST7R_ARATH 4.00E-139 GO:0047598; GO:0005794; GO:0016132; GO:0006695; GO:0005789; GO:0016021; GO:0005886; GO:0009918 Q8VZW1 7-dehydrocholesterol reductase activity; Golgi apparatus; brassinosteroid biosynthetic process; cholesterol biosynthetic process; endoplasmic reticulum membrane; integral to membrane; plasma membrane; sterol delta7 reductase activity IPR001171; IPR018083; Lipid metabolism; steroid biosynthesis. 7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Protein DWARF 5) (Sterol Delta(7)-reductase) DWF5 ST7R At1g50430 F11F12.21 Arabidopsis thaliana (Mouse-ear cress) TR42556_c2_g4_i2 O08984 LBR_RAT 4.00E-50 GO:0003677; GO:0005637; GO:0005643; GO:0016628 "DNA binding; nuclear inner membrane; nuclear pore; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor" IPR001171; IPR019023; IPR018083; IPR002999; Lamin-B receptor (Integral nuclear envelope inner membrane protein) (NBP60) Lbr Rattus norvegicus (Rat) TR42557_c2_g2_i1 Q23551 UNC22_CAEEL 3.00E-20 GO:0031672; GO:0005524; GO:0046872; GO:0004674 A band; ATP binding; metal ion binding; protein serine/threonine kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans TR42557_c2_g2_i2 Q58DA5 NTRI_BOVIN 3.00E-08 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Neurotrimin NTM NT Bos taurus (Bovine) TR42557_c2_g2_i3 Q3KNY0 IGFN1_MOUSE 6.00E-07 GO:0030018; GO:0005634 Z disc; nucleus IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Immunoglobulin-like and fibronectin type III domain-containing protein 1 Igfn1 Mus musculus (Mouse) TR42557_c2_g2_i4 Q8WZ42 TITIN_HUMAN 2.00E-61 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR42557_c2_g2_i5 Q9I7U4 TITIN_DROME 7.00E-32 GO:0030018; GO:0003779; GO:0051301; GO:0000794; GO:0040011; GO:0007498; GO:0005875; GO:0007076; GO:0016203; GO:0007520; GO:0035206; GO:0045214; GO:0007062; GO:0007519; GO:0007525; GO:0008307; GO:0007522 Z disc; actin binding; cell division; condensed nuclear chromosome; locomotion; mesoderm development; microtubule associated complex; mitotic chromosome condensation; muscle attachment; myoblast fusion; regulation of hemocyte proliferation; sarcomere organization; sister chromatid cohesion; skeletal muscle tissue development; somatic muscle development; structural constituent of muscle; visceral muscle development IPR010939; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR001452; Titin (D-Titin) (Kettin) sls titin CG1915 Drosophila melanogaster (Fruit fly) TR42557_c2_g2_i6 P56276 MYLK_MELGA 1.00E-15 IPR007110; IPR013783; IPR013098; IPR003598; IPR020675; Telokin Meleagris gallopavo (Common turkey) TR42557_c2_g2_i7 Q8AXY6 MUSK_CHICK 5.00E-11 GO:0005524; GO:0030154; GO:0030054; GO:0016021; GO:0007275; GO:0018108; GO:0005886; GO:0045211; GO:0008582; GO:0004714 ATP binding; cell differentiation; cell junction; integral to membrane; multicellular organismal development; peptidyl-tyrosine phosphorylation; plasma membrane; postsynaptic membrane; regulation of synaptic growth at neuromuscular junction; transmembrane receptor protein tyrosine kinase activity IPR020067; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000001; IPR013806; IPR018056; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; "Muscle, skeletal receptor tyrosine protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)" MUSK Gallus gallus (Chicken) TR42559_c0_g2_i1 Q8N136 WDR69_HUMAN 5.00E-07 GO:0005929 cilium IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Dynein assembly factor with WDR repeat domains 1 (Outer row dynein assembly protein 16 homolog) (WD repeat-containing protein 69) DAW1 WDR69 Homo sapiens (Human) TR42559_c0_g2_i2 Q8BPN8 DMXL2_MOUSE 2.00E-96 GO:0030054; GO:0030672 cell junction; synaptic vesicle membrane IPR022033; IPR015943; IPR001680; IPR017986; DmX-like protein 2 (Rabconnectin-3) Dmxl2 Kiaa0856 Mus musculus (Mouse) TR42561_c0_g1_i1 P91766 ACH1_MANSE 2.00E-143 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha-like (MARA1) ARA1 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) TR42561_c0_g1_i2 P25162 ACH4_DROME 4.00E-140 GO:0004889; GO:0005892; GO:0030054; GO:0045211; GO:0017085; GO:0007271 "acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; postsynaptic membrane; response to insecticide; synaptic transmission, cholinergic" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit beta-like 2 nAcRbeta-96A Acr96Ac AcrF SBD CG6798 Drosophila melanogaster (Fruit fly) TR42561_c0_g1_i3 Q9R0W9 ACHA6_MOUSE 3.00E-116 GO:0004889; GO:0005892; GO:0030054; GO:0051899; GO:0045211; GO:0014059 acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; membrane depolarization; postsynaptic membrane; regulation of dopamine secretion IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Nica6 Mus musculus (Mouse) TR42561_c0_g1_i4 P43143 ACHA6_RAT 2.00E-120 GO:0004889; GO:0005892; GO:0030054; GO:0008144; GO:0045211; GO:0051291 acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; drug binding; postsynaptic membrane; protein heterooligomerization IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Acra6 Rattus norvegicus (Rat) TR42561_c0_g1_i5 P91766 ACH1_MANSE 1.00E-141 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha-like (MARA1) ARA1 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) TR42561_c0_g1_i6 P04757 ACHA3_RAT 9.00E-112 GO:0042166; GO:0015464; GO:0004889; GO:0005892; GO:0030054; GO:0030425; GO:0008144; GO:0007507; GO:0043025; GO:0014069; GO:0045211; GO:0051291; GO:0042493; GO:0010035; GO:0035094 acetylcholine binding; acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; dendrite; drug binding; heart development; neuronal cell body; postsynaptic density; postsynaptic membrane; protein heterooligomerization; response to drug; response to inorganic substance; response to nicotine IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-3 Chrna3 Acra3 Rattus norvegicus (Rat) TR42563_c3_g2_i1 Q7ZYG4 OSTF1_XENLA 5.00E-67 GO:0005737 cytoplasm IPR002110; IPR020683; IPR000108; IPR001452; Osteoclast-stimulating factor 1 ostf1 Xenopus laevis (African clawed frog) TR42564_c0_g1_i1 O14974 MYPT1_HUMAN 1.00E-106 GO:0071889; GO:0000086; GO:0072357; GO:0005813; GO:0051297; GO:0043292; GO:0004857; GO:0000776; GO:0007067; GO:0005654; GO:0019208; GO:0045944; GO:0006470; GO:0030155; GO:0035507; GO:0046822; GO:0004871 14-3-3 protein binding; G2/M transition of mitotic cell cycle; PTW/PP1 phosphatase complex; centrosome; centrosome organization; contractile fiber; enzyme inhibitor activity; kinetochore; mitosis; nucleoplasm; phosphatase regulator activity; positive regulation of transcription from RNA polymerase II promoter; protein dephosphorylation; regulation of cell adhesion; regulation of myosin-light-chain-phosphatase activity; regulation of nucleocytoplasmic transport; signal transducer activity IPR002110; IPR020683; IPR017401; Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) PPP1R12A MBS MYPT1 Homo sapiens (Human) TR42564_c0_g1_i2 O14974 MYPT1_HUMAN 1.00E-106 GO:0071889; GO:0000086; GO:0072357; GO:0005813; GO:0051297; GO:0043292; GO:0004857; GO:0000776; GO:0007067; GO:0005654; GO:0019208; GO:0045944; GO:0006470; GO:0030155; GO:0035507; GO:0046822; GO:0004871 14-3-3 protein binding; G2/M transition of mitotic cell cycle; PTW/PP1 phosphatase complex; centrosome; centrosome organization; contractile fiber; enzyme inhibitor activity; kinetochore; mitosis; nucleoplasm; phosphatase regulator activity; positive regulation of transcription from RNA polymerase II promoter; protein dephosphorylation; regulation of cell adhesion; regulation of myosin-light-chain-phosphatase activity; regulation of nucleocytoplasmic transport; signal transducer activity IPR002110; IPR020683; IPR017401; Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) PPP1R12A MBS MYPT1 Homo sapiens (Human) TR42564_c0_g1_i4 Q5DU14 MYO16_MOUSE 8.00E-28 GO:0005524; GO:0051015; GO:0021549; GO:0005829; GO:0003774; GO:0016459; GO:2000134; GO:0008285; GO:0048812; GO:0005730; GO:0005654; GO:0048471; GO:0014065; GO:0005886 P28660 ATP binding; actin filament binding; cerebellum development; cytosol; motor activity; myosin complex; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell proliferation; neuron projection morphogenesis; nucleolus; nucleoplasm; perinuclear region of cytoplasm; phosphatidylinositol 3-kinase cascade; plasma membrane IPR002110; IPR020683; IPR000048; IPR001609; IPR027417; Unconventional myosin-XVI (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16) Myo16 Kiaa0865 Nyap3 Mus musculus (Mouse) TR42564_c0_g1_i5 O60237 MYPT2_HUMAN 3.00E-106 GO:0000086; GO:0015629; GO:0005737; GO:0008047; GO:0005654; GO:0005886; GO:0006937; GO:0007165 G2/M transition of mitotic cell cycle; actin cytoskeleton; cytoplasm; enzyme activator activity; nucleoplasm; plasma membrane; regulation of muscle contraction; signal transduction IPR002110; IPR020683; IPR017401; Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) PPP1R12B MYPT2 Homo sapiens (Human) TR42564_c0_g1_i6 Q10728 MYPT1_RAT 7.00E-111 GO:0071889; GO:0072357; GO:0005813; GO:0051297; GO:0005737; GO:0004857; GO:0000776; GO:0007067; GO:0019208; GO:0004721; GO:0045944; GO:0006470; GO:0030155; GO:0035507 Q6WCQ1; P35240 14-3-3 protein binding; PTW/PP1 phosphatase complex; centrosome; centrosome organization; cytoplasm; enzyme inhibitor activity; kinetochore; mitosis; phosphatase regulator activity; phosphoprotein phosphatase activity; positive regulation of transcription from RNA polymerase II promoter; protein dephosphorylation; regulation of cell adhesion; regulation of myosin-light-chain-phosphatase activity IPR002110; IPR020683; IPR017401; Protein phosphatase 1 regulatory subunit 12A (MBSP) (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) (Protein phosphatase subunit 1M) (PP-1M) (Serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110) Ppp1r12a Mbs Mypt1 Rattus norvegicus (Rat) TR42564_c0_g1_i7 O14974 MYPT1_HUMAN 4.00E-111 GO:0071889; GO:0000086; GO:0072357; GO:0005813; GO:0051297; GO:0043292; GO:0004857; GO:0000776; GO:0007067; GO:0005654; GO:0019208; GO:0045944; GO:0006470; GO:0030155; GO:0035507; GO:0046822; GO:0004871 14-3-3 protein binding; G2/M transition of mitotic cell cycle; PTW/PP1 phosphatase complex; centrosome; centrosome organization; contractile fiber; enzyme inhibitor activity; kinetochore; mitosis; nucleoplasm; phosphatase regulator activity; positive regulation of transcription from RNA polymerase II promoter; protein dephosphorylation; regulation of cell adhesion; regulation of myosin-light-chain-phosphatase activity; regulation of nucleocytoplasmic transport; signal transducer activity IPR002110; IPR020683; IPR017401; Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) PPP1R12A MBS MYPT1 Homo sapiens (Human) TR42566_c0_g1_i1 O54975 XPP1_RAT 1.00E-100 GO:0010815; GO:0005829; GO:0030145; GO:0070006; GO:0006508 bradykinin catabolic process; cytosol; manganese ion binding; metalloaminopeptidase activity; proteolysis IPR000587; IPR000994; IPR001131; "Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble) [Cleaved into: Xaa-Pro aminopeptidase 1, N-terminally processed]" Xpnpep1 App Rattus norvegicus (Rat) TR42566_c0_g1_i4 Q9NQW7 XPP1_HUMAN 3.00E-38 GO:0010815; GO:0005737; GO:0005829; GO:0030145; GO:0070006; GO:0006508 bradykinin catabolic process; cytoplasm; cytosol; manganese ion binding; metalloaminopeptidase activity; proteolysis IPR000587; IPR000994; IPR001131; "Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble)" XPNPEP1 XPNPEPL XPNPEPL1 Homo sapiens (Human) TR42566_c0_g4_i5 C5FHR9 AMPP1_ARTOC 2.00E-21 GO:0004177; GO:0009987; GO:0046872; GO:0008237; GO:0006508 aminopeptidase activity; cellular process; metal ion binding; metallopeptidase activity; proteolysis IPR000587; IPR000994; IPR001131; Probable Xaa-Pro aminopeptidase P (AMPP) (Aminopeptidase P) (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Prolidase) AMPP MCYG_01718 Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis) TR42567_c0_g3_i1 P61025 CKS1_MOUSE 3.00E-27 GO:0007049; GO:0051301; GO:0016538 cell cycle; cell division; cyclin-dependent protein serine/threonine kinase regulator activity IPR000789; Cyclin-dependent kinases regulatory subunit 1 (CKS-1) (Sid 1334) Cks1b Cks1 Sid1334 Mus musculus (Mouse) TR42570_c0_g2_i1 Q9H2U1 DHX36_HUMAN 0 GO:0005524; GO:0008026; GO:0005829; GO:0003725; GO:0045087; GO:0005634; GO:0032481; GO:0043330; GO:0009615 ATP binding; ATP-dependent helicase activity; cytosol; double-stranded RNA binding; innate immune response; nucleus; positive regulation of type I interferon production; response to exogenous dsRNA; response to virus IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Probable ATP-dependent RNA helicase DHX36 (EC 3.6.4.13) (DEAH box protein 36) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE) DHX36 DDX36 KIAA1488 MLEL1 RHAU Homo sapiens (Human) TR42570_c0_g3_i1 Q9H2U1 DHX36_HUMAN 5.00E-20 GO:0005524; GO:0008026; GO:0005829; GO:0003725; GO:0045087; GO:0005634; GO:0032481; GO:0043330; GO:0009615 ATP binding; ATP-dependent helicase activity; cytosol; double-stranded RNA binding; innate immune response; nucleus; positive regulation of type I interferon production; response to exogenous dsRNA; response to virus IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; Probable ATP-dependent RNA helicase DHX36 (EC 3.6.4.13) (DEAH box protein 36) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE) DHX36 DDX36 KIAA1488 MLEL1 RHAU Homo sapiens (Human) TR42571_c2_g1_i3 Q9P2D3 HTR5B_HUMAN 0 IPR011989; IPR016024; HEAT repeat-containing protein 5B HEATR5B KIAA1414 Homo sapiens (Human) TR42571_c2_g3_i1 O42998 SIP1_SCHPO 3.00E-20 GO:0005794; GO:0007049; GO:0051301; GO:0005829; GO:0030139; GO:0006897; GO:0006886; GO:0005634; GO:0043234; GO:0042147 "Golgi apparatus; cell cycle; cell division; cytosol; endocytic vesicle; endocytosis; intracellular protein transport; nucleus; protein complex; retrograde transport, endosome to Golgi" IPR016024; Pof6 interactor protein 1 sip1 pi070 SPBC27B12.08 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42571_c2_g3_i2 Q86XA9 HTR5A_HUMAN 4.00E-07 IPR011989; IPR016024; HEAT repeat-containing protein 5A HEATR5A C14orf125 KIAA1316 Homo sapiens (Human) TR42571_c2_g4_i1 Q9P2D3 HTR5B_HUMAN 4.00E-26 IPR011989; IPR016024; HEAT repeat-containing protein 5B HEATR5B KIAA1414 Homo sapiens (Human) TR42573_c3_g1_i1 Q0S808 HSAB_RHOSR 6.00E-14 GO:0010181; GO:0019439; GO:0036382; GO:0016042; GO:0042602; GO:0006694 FMN binding; aromatic compound catabolic process; flavin reductase (NADH) activity; lipid catabolic process; riboflavin reductase (NADPH) activity; steroid biosynthetic process IPR002563; IPR012349; Lipid metabolism; steroid biosynthesis. "Flavin-dependent monooxygenase, reductase subunit HsaB (EC 1.5.1.36) (3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4-hydroxylase, reductase subunit) (Flavin:NADH reductase)" hsaB RHA1_ro04542 Rhodococcus sp. (strain RHA1) TR42575_c0_g1_i3 P27653 C1TC_RAT 0 GO:0005524; GO:0005829; GO:0009396; GO:0004329; GO:0000105; GO:0004477; GO:0009086; GO:0004488; GO:0004486; GO:0009117; GO:0006730; GO:0006164; GO:0035999; GO:0046653 ATP binding; cytosol; folic acid-containing compound biosynthetic process; formate-tetrahydrofolate ligase activity; histidine biosynthetic process; methenyltetrahydrofolate cyclohydrolase activity; methionine biosynthetic process; methylenetetrahydrofolate dehydrogenase (NADP+) activity; methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity; nucleotide metabolic process; one-carbon metabolic process; purine nucleotide biosynthetic process; tetrahydrofolate interconversion; tetrahydrofolate metabolic process IPR000559; IPR020628; IPR016040; IPR027417; IPR000672; IPR020630; IPR020867; IPR020631; One-carbon metabolism; tetrahydrofolate interconversion. "C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]" Mthfd1 Mthfd Rattus norvegicus (Rat) TR42575_c0_g1_i5 Q9SPK5 FTHS_ARATH 0 GO:0005524; GO:0048046; GO:0009507; GO:0005507; GO:0005829; GO:0009396; GO:0004329; GO:0005886; GO:0046686; GO:0035999 ATP binding; apoplast; chloroplast; copper ion binding; cytosol; folic acid-containing compound biosynthetic process; formate-tetrahydrofolate ligase activity; plasma membrane; response to cadmium ion; tetrahydrofolate interconversion IPR000559; IPR020628; IPR027417; One-carbon metabolism; tetrahydrofolate interconversion. Formate--tetrahydrofolate ligase (EC 6.3.4.3) (10-formyletrahydrofolate synthetase) (FHS) (FTHFS) (Formyltetrahydrofolate synthetase) THFS At1g50480 F11F12.17 F17J6.2 Arabidopsis thaliana (Mouse-ear cress) TR42575_c0_g4_i2 P27653 C1TC_RAT 8.00E-33 GO:0005524; GO:0005829; GO:0009396; GO:0004329; GO:0000105; GO:0004477; GO:0009086; GO:0004488; GO:0004486; GO:0009117; GO:0006730; GO:0006164; GO:0035999; GO:0046653 ATP binding; cytosol; folic acid-containing compound biosynthetic process; formate-tetrahydrofolate ligase activity; histidine biosynthetic process; methenyltetrahydrofolate cyclohydrolase activity; methionine biosynthetic process; methylenetetrahydrofolate dehydrogenase (NADP+) activity; methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity; nucleotide metabolic process; one-carbon metabolic process; purine nucleotide biosynthetic process; tetrahydrofolate interconversion; tetrahydrofolate metabolic process IPR000559; IPR020628; IPR016040; IPR027417; IPR000672; IPR020630; IPR020867; IPR020631; One-carbon metabolism; tetrahydrofolate interconversion. "C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]" Mthfd1 Mthfd Rattus norvegicus (Rat) TR42576_c5_g1_i1 P19971 TYPH_HUMAN 6.00E-116 GO:0006260; GO:0001525; GO:0030154; GO:0006935; GO:0005829; GO:0000002; GO:0004645; GO:0005161; GO:0006206; GO:0046135; GO:0043097; GO:0006220; GO:0016154; GO:0009032 DNA replication; angiogenesis; cell differentiation; chemotaxis; cytosol; mitochondrial genome maintenance; phosphorylase activity; platelet-derived growth factor receptor binding; pyrimidine nucleobase metabolic process; pyrimidine nucleoside catabolic process; pyrimidine nucleoside salvage; pyrimidine nucleotide metabolic process; pyrimidine-nucleoside phosphorylase activity; thymidine phosphorylase activity IPR000312; IPR017459; IPR013102; IPR018090; IPR000053; IPR017872; Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase) TYMP ECGF1 Homo sapiens (Human) TR42578_c1_g1_i1 Q3U4G3 XXLT1_MOUSE 2.00E-70 GO:0005789; GO:0016021; GO:0016763 "endoplasmic reticulum membrane; integral to membrane; transferase activity, transferring pentosyl groups" IPR002495; "Xyloside xylosyltransferase 1 (EC 2.4.2.n3) (UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase)" Xxylt1 Mus musculus (Mouse) TR42578_c2_g1_i2 P62257 UBE2H_MOUSE 5.00E-80 GO:0005524; GO:0070979; GO:0070936; GO:0004842 ATP binding; protein K11-linked ubiquitination; protein K48-linked ubiquitination; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 H (EC 6.3.2.19) (UBCH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H) Ube2h Mus musculus (Mouse) TR42580_c0_g1_i1 Q14BN4 SLMAP_HUMAN 2.00E-128 GO:0005887; GO:0005815; GO:0006936; GO:0042383; GO:0005790 Q96CV9; Q13188; Q13043 integral to plasma membrane; microtubule organizing center; muscle contraction; sarcolemma; smooth endoplasmic reticulum IPR000253; IPR008984; Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) SLMAP KIAA1601 SLAP UNQ1847/PRO3577 Homo sapiens (Human) TR42580_c0_g1_i3 Q14BN4 SLMAP_HUMAN 2.00E-128 GO:0005887; GO:0005815; GO:0006936; GO:0042383; GO:0005790 Q96CV9; Q13188; Q13043 integral to plasma membrane; microtubule organizing center; muscle contraction; sarcolemma; smooth endoplasmic reticulum IPR000253; IPR008984; Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) SLMAP KIAA1601 SLAP UNQ1847/PRO3577 Homo sapiens (Human) TR42580_c0_g1_i5 Q14BN4 SLMAP_HUMAN 2.00E-128 GO:0005887; GO:0005815; GO:0006936; GO:0042383; GO:0005790 Q96CV9; Q13188; Q13043 integral to plasma membrane; microtubule organizing center; muscle contraction; sarcolemma; smooth endoplasmic reticulum IPR000253; IPR008984; Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) SLMAP KIAA1601 SLAP UNQ1847/PRO3577 Homo sapiens (Human) TR42580_c0_g1_i7 Q14BN4 SLMAP_HUMAN 2.00E-128 GO:0005887; GO:0005815; GO:0006936; GO:0042383; GO:0005790 Q96CV9; Q13188; Q13043 integral to plasma membrane; microtubule organizing center; muscle contraction; sarcolemma; smooth endoplasmic reticulum IPR000253; IPR008984; Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) SLMAP KIAA1601 SLAP UNQ1847/PRO3577 Homo sapiens (Human) TR42580_c0_g1_i9 Q14BN4 SLMAP_HUMAN 2.00E-128 GO:0005887; GO:0005815; GO:0006936; GO:0042383; GO:0005790 Q96CV9; Q13188; Q13043 integral to plasma membrane; microtubule organizing center; muscle contraction; sarcolemma; smooth endoplasmic reticulum IPR000253; IPR008984; Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) SLMAP KIAA1601 SLAP UNQ1847/PRO3577 Homo sapiens (Human) TR42581_c1_g1_i1 A2VDZ3 MEF2A_BOVIN 5.00E-68 GO:0070375; GO:0000977; GO:0001105; GO:0046332; GO:0033613; GO:0006915; GO:0061337; GO:0071277; GO:0003682; GO:0048813; GO:0035035; GO:0042826; GO:0000002; GO:0048311; GO:0000122; GO:0000790; GO:0005634; GO:0045944; GO:0000981; GO:0055005 ERK5 cascade; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription coactivator activity; SMAD binding; activating transcription factor binding; apoptotic process; cardiac conduction; cellular response to calcium ion; chromatin binding; dendrite morphogenesis; histone acetyltransferase binding; histone deacetylase binding; mitochondrial genome maintenance; mitochondrion distribution; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding RNA polymerase II transcription factor activity; ventricular cardiac myofibril assembly IPR022102; IPR002100; Myocyte-specific enhancer factor 2A MEF2A Bos taurus (Bovine) TR42581_c1_g1_i2 A4UTP7 MEF2C_PIG 2.00E-68 GO:0001782; GO:0042100; GO:0050853; GO:0000165; GO:0001077; GO:0000983; GO:0000977; GO:0001568; GO:0001974; GO:0003211; GO:0071277; GO:0035690; GO:0071498; GO:0071222; GO:0071374; GO:0071560; GO:0035984; GO:0002062; GO:0005737; GO:0001958; GO:2001013; GO:0002467; GO:0072102; GO:0001947; GO:0006959; GO:0007611; GO:0030318; GO:0035198; GO:0007521; GO:0043524; GO:0030279; GO:0000122; GO:0072160; GO:0014033; GO:0048666; GO:0016607; GO:0001649; GO:0003151; GO:0030220; GO:0030890; GO:0010694; GO:2000987; GO:0030501; GO:2000727; GO:0060045; GO:2000111; GO:0045663; GO:0045666; GO:0045669; GO:0090073; GO:2001016; GO:0048643; GO:0003138; GO:0043234; GO:0002634; GO:0045652; GO:0060025; GO:0003139; GO:0003185; GO:0007519; GO:0051145; GO:0055012 B cell homeostasis; B cell proliferation; B cell receptor signaling pathway; MAPK cascade; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; RNA polymerase II regulatory region sequence-specific DNA binding; blood vessel development; blood vessel remodeling; cardiac ventricle formation; cellular response to calcium ion; cellular response to drug; cellular response to fluid shear stress; cellular response to lipopolysaccharide; cellular response to parathyroid hormone stimulus; cellular response to transforming growth factor beta stimulus; cellular response to trichostatin A; chondrocyte differentiation; cytoplasm; endochondral ossification; epithelial cell proliferation involved in renal tubule morphogenesis; germinal center formation; glomerulus morphogenesis; heart looping; humoral immune response; learning or memory; melanocyte differentiation; miRNA binding; muscle cell fate determination; negative regulation of neuron apoptotic process; negative regulation of ossification; negative regulation of transcription from RNA polymerase II promoter; nephron tubule epithelial cell differentiation; neural crest cell differentiation; neuron development; nuclear speck; osteoblast differentiation; outflow tract morphogenesis; platelet formation; positive regulation of B cell proliferation; positive regulation of alkaline phosphatase activity; positive regulation of behavioral fear response; positive regulation of bone mineralization; positive regulation of cardiac muscle cell differentiation; positive regulation of cardiac muscle cell proliferation; positive regulation of macrophage apoptotic process; positive regulation of myoblast differentiation; positive regulation of neuron differentiation; positive regulation of osteoblast differentiation; positive regulation of protein homodimerization activity; positive regulation of skeletal muscle cell differentiation; positive regulation of skeletal muscle tissue development; primary heart field specification; protein complex; regulation of germinal center formation; regulation of megakaryocyte differentiation; regulation of synaptic activity; secondary heart field specification; sinoatrial valve morphogenesis; skeletal muscle tissue development; smooth muscle cell differentiation; ventricular cardiac muscle cell differentiation IPR022102; IPR002100; Myocyte-specific enhancer factor 2C MEF2C Sus scrofa (Pig) TR42581_c1_g1_i8 A4UTP7 MEF2C_PIG 1.00E-68 GO:0001782; GO:0042100; GO:0050853; GO:0000165; GO:0001077; GO:0000983; GO:0000977; GO:0001568; GO:0001974; GO:0003211; GO:0071277; GO:0035690; GO:0071498; GO:0071222; GO:0071374; GO:0071560; GO:0035984; GO:0002062; GO:0005737; GO:0001958; GO:2001013; GO:0002467; GO:0072102; GO:0001947; GO:0006959; GO:0007611; GO:0030318; GO:0035198; GO:0007521; GO:0043524; GO:0030279; GO:0000122; GO:0072160; GO:0014033; GO:0048666; GO:0016607; GO:0001649; GO:0003151; GO:0030220; GO:0030890; GO:0010694; GO:2000987; GO:0030501; GO:2000727; GO:0060045; GO:2000111; GO:0045663; GO:0045666; GO:0045669; GO:0090073; GO:2001016; GO:0048643; GO:0003138; GO:0043234; GO:0002634; GO:0045652; GO:0060025; GO:0003139; GO:0003185; GO:0007519; GO:0051145; GO:0055012 B cell homeostasis; B cell proliferation; B cell receptor signaling pathway; MAPK cascade; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; RNA polymerase II regulatory region sequence-specific DNA binding; blood vessel development; blood vessel remodeling; cardiac ventricle formation; cellular response to calcium ion; cellular response to drug; cellular response to fluid shear stress; cellular response to lipopolysaccharide; cellular response to parathyroid hormone stimulus; cellular response to transforming growth factor beta stimulus; cellular response to trichostatin A; chondrocyte differentiation; cytoplasm; endochondral ossification; epithelial cell proliferation involved in renal tubule morphogenesis; germinal center formation; glomerulus morphogenesis; heart looping; humoral immune response; learning or memory; melanocyte differentiation; miRNA binding; muscle cell fate determination; negative regulation of neuron apoptotic process; negative regulation of ossification; negative regulation of transcription from RNA polymerase II promoter; nephron tubule epithelial cell differentiation; neural crest cell differentiation; neuron development; nuclear speck; osteoblast differentiation; outflow tract morphogenesis; platelet formation; positive regulation of B cell proliferation; positive regulation of alkaline phosphatase activity; positive regulation of behavioral fear response; positive regulation of bone mineralization; positive regulation of cardiac muscle cell differentiation; positive regulation of cardiac muscle cell proliferation; positive regulation of macrophage apoptotic process; positive regulation of myoblast differentiation; positive regulation of neuron differentiation; positive regulation of osteoblast differentiation; positive regulation of protein homodimerization activity; positive regulation of skeletal muscle cell differentiation; positive regulation of skeletal muscle tissue development; primary heart field specification; protein complex; regulation of germinal center formation; regulation of megakaryocyte differentiation; regulation of synaptic activity; secondary heart field specification; sinoatrial valve morphogenesis; skeletal muscle tissue development; smooth muscle cell differentiation; ventricular cardiac muscle cell differentiation IPR022102; IPR002100; Myocyte-specific enhancer factor 2C MEF2C Sus scrofa (Pig) TR42581_c1_g1_i9 A4UTP7 MEF2C_PIG 2.00E-69 GO:0001782; GO:0042100; GO:0050853; GO:0000165; GO:0001077; GO:0000983; GO:0000977; GO:0001568; GO:0001974; GO:0003211; GO:0071277; GO:0035690; GO:0071498; GO:0071222; GO:0071374; GO:0071560; GO:0035984; GO:0002062; GO:0005737; GO:0001958; GO:2001013; GO:0002467; GO:0072102; GO:0001947; GO:0006959; GO:0007611; GO:0030318; GO:0035198; GO:0007521; GO:0043524; GO:0030279; GO:0000122; GO:0072160; GO:0014033; GO:0048666; GO:0016607; GO:0001649; GO:0003151; GO:0030220; GO:0030890; GO:0010694; GO:2000987; GO:0030501; GO:2000727; GO:0060045; GO:2000111; GO:0045663; GO:0045666; GO:0045669; GO:0090073; GO:2001016; GO:0048643; GO:0003138; GO:0043234; GO:0002634; GO:0045652; GO:0060025; GO:0003139; GO:0003185; GO:0007519; GO:0051145; GO:0055012 B cell homeostasis; B cell proliferation; B cell receptor signaling pathway; MAPK cascade; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; RNA polymerase II regulatory region sequence-specific DNA binding; blood vessel development; blood vessel remodeling; cardiac ventricle formation; cellular response to calcium ion; cellular response to drug; cellular response to fluid shear stress; cellular response to lipopolysaccharide; cellular response to parathyroid hormone stimulus; cellular response to transforming growth factor beta stimulus; cellular response to trichostatin A; chondrocyte differentiation; cytoplasm; endochondral ossification; epithelial cell proliferation involved in renal tubule morphogenesis; germinal center formation; glomerulus morphogenesis; heart looping; humoral immune response; learning or memory; melanocyte differentiation; miRNA binding; muscle cell fate determination; negative regulation of neuron apoptotic process; negative regulation of ossification; negative regulation of transcription from RNA polymerase II promoter; nephron tubule epithelial cell differentiation; neural crest cell differentiation; neuron development; nuclear speck; osteoblast differentiation; outflow tract morphogenesis; platelet formation; positive regulation of B cell proliferation; positive regulation of alkaline phosphatase activity; positive regulation of behavioral fear response; positive regulation of bone mineralization; positive regulation of cardiac muscle cell differentiation; positive regulation of cardiac muscle cell proliferation; positive regulation of macrophage apoptotic process; positive regulation of myoblast differentiation; positive regulation of neuron differentiation; positive regulation of osteoblast differentiation; positive regulation of protein homodimerization activity; positive regulation of skeletal muscle cell differentiation; positive regulation of skeletal muscle tissue development; primary heart field specification; protein complex; regulation of germinal center formation; regulation of megakaryocyte differentiation; regulation of synaptic activity; secondary heart field specification; sinoatrial valve morphogenesis; skeletal muscle tissue development; smooth muscle cell differentiation; ventricular cardiac muscle cell differentiation IPR022102; IPR002100; Myocyte-specific enhancer factor 2C MEF2C Sus scrofa (Pig) TR42582_c1_g2_i1 P53708 ITA8_HUMAN 5.00E-67 GO:0034678; GO:0045177; GO:0030030; GO:0016337; GO:0007160; GO:0045184; GO:0030198; GO:0042472; GO:0007229; GO:0007613; GO:0046872; GO:0001656; GO:0007399; GO:2000721; GO:0030511; GO:0048745 alpha8-beta1 integrin complex; apical part of cell; cell projection organization; cell-cell adhesion; cell-matrix adhesion; establishment of protein localization; extracellular matrix organization; inner ear morphogenesis; integrin-mediated signaling pathway; memory; metal ion binding; metanephros development; nervous system development; positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; positive regulation of transforming growth factor beta receptor signaling pathway; smooth muscle tissue development IPR013517; IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] ITGA8 Homo sapiens (Human) TR42585_c3_g1_i2 Q12912 LRMP_HUMAN 2.00E-35 GO:0005789; GO:0030176; GO:0005887; GO:0006906; GO:0006903 endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; integral to plasma membrane; vesicle fusion; vesicle targeting IPR008677; Lymphoid-restricted membrane protein (Protein Jaw1) [Cleaved into: Processed lymphoid-restricted membrane protein] LRMP JAW1 Homo sapiens (Human) TR42585_c3_g1_i5 Q12912 LRMP_HUMAN 8.00E-35 GO:0005789; GO:0030176; GO:0005887; GO:0006906; GO:0006903 endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; integral to plasma membrane; vesicle fusion; vesicle targeting IPR008677; Lymphoid-restricted membrane protein (Protein Jaw1) [Cleaved into: Processed lymphoid-restricted membrane protein] LRMP JAW1 Homo sapiens (Human) TR42586_c1_g1_i2 Q3ZBB1 SH21A_BOVIN 8.00E-13 GO:0007267; GO:0006968; GO:0005737; GO:0006959; GO:0045954 cell-cell signaling; cellular defense response; cytoplasm; humoral immune response; positive regulation of natural killer cell mediated cytotoxicity IPR000980; IPR017289; SH2 domain-containing protein 1A SH2D1A Bos taurus (Bovine) TR42586_c1_g1_i3 Q9WVR3 SHIP2_RAT 3.00E-173 GO:0005794; GO:0007015; GO:0007420; GO:0007155; GO:0005856; GO:0005829; GO:0001958; GO:0006897; GO:0030175; GO:0006006; GO:0032957; GO:0004445; GO:0030027; GO:0008156; GO:0043407; GO:0008285; GO:0010629; GO:0046627; GO:0043569; GO:0010977; GO:0010642; GO:0006661; GO:0046856; GO:0005547; GO:0005886; GO:0009791; GO:0042493; GO:0032868; GO:0097178 "Golgi apparatus; actin filament organization; brain development; cell adhesion; cytoskeleton; cytosol; endochondral ossification; endocytosis; filopodium; glucose metabolic process; inositol trisphosphate metabolic process; inositol-polyphosphate 5-phosphatase activity; lamellipodium; negative regulation of DNA replication; negative regulation of MAP kinase activity; negative regulation of cell proliferation; negative regulation of gene expression; negative regulation of insulin receptor signaling pathway; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of neuron projection development; negative regulation of platelet-derived growth factor receptor signaling pathway; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; phosphatidylinositol-3,4,5-trisphosphate binding; plasma membrane; post-embryonic development; response to drug; response to insulin stimulus; ruffle assembly" IPR005135; IPR000300; IPR001660; IPR013761; IPR021129; IPR000980; "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)" Inppl1 Ship2 Rattus norvegicus (Rat) TR42586_c1_g1_i4 O15357 SHIP2_HUMAN 6.00E-172 GO:0005794; GO:0007015; GO:0007420; GO:0007155; GO:0005856; GO:0005829; GO:0001958; GO:0006897; GO:0030175; GO:0006006; GO:0043647; GO:0032957; GO:0004445; GO:0030027; GO:0008156; GO:0043407; GO:0008285; GO:0010629; GO:0046627; GO:0043569; GO:0010977; GO:0010642; GO:0006661; GO:0046856; GO:0005547; GO:0005886; GO:0009791; GO:0042493; GO:0032868; GO:0097178 P56945; Q8IV36; Q15811-2; Q9BX66; O60504-1 "Golgi apparatus; actin filament organization; brain development; cell adhesion; cytoskeleton; cytosol; endochondral ossification; endocytosis; filopodium; glucose metabolic process; inositol phosphate metabolic process; inositol trisphosphate metabolic process; inositol-polyphosphate 5-phosphatase activity; lamellipodium; negative regulation of DNA replication; negative regulation of MAP kinase activity; negative regulation of cell proliferation; negative regulation of gene expression; negative regulation of insulin receptor signaling pathway; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of neuron projection development; negative regulation of platelet-derived growth factor receptor signaling pathway; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; phosphatidylinositol-3,4,5-trisphosphate binding; plasma membrane; post-embryonic development; response to drug; response to insulin stimulus; ruffle assembly" IPR005135; IPR000300; IPR001660; IPR013761; IPR021129; IPR000980; "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)" INPPL1 SHIP2 Homo sapiens (Human) TR42586_c1_g1_i5 Q9WVR3 SHIP2_RAT 3.00E-173 GO:0005794; GO:0007015; GO:0007420; GO:0007155; GO:0005856; GO:0005829; GO:0001958; GO:0006897; GO:0030175; GO:0006006; GO:0032957; GO:0004445; GO:0030027; GO:0008156; GO:0043407; GO:0008285; GO:0010629; GO:0046627; GO:0043569; GO:0010977; GO:0010642; GO:0006661; GO:0046856; GO:0005547; GO:0005886; GO:0009791; GO:0042493; GO:0032868; GO:0097178 "Golgi apparatus; actin filament organization; brain development; cell adhesion; cytoskeleton; cytosol; endochondral ossification; endocytosis; filopodium; glucose metabolic process; inositol trisphosphate metabolic process; inositol-polyphosphate 5-phosphatase activity; lamellipodium; negative regulation of DNA replication; negative regulation of MAP kinase activity; negative regulation of cell proliferation; negative regulation of gene expression; negative regulation of insulin receptor signaling pathway; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of neuron projection development; negative regulation of platelet-derived growth factor receptor signaling pathway; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; phosphatidylinositol-3,4,5-trisphosphate binding; plasma membrane; post-embryonic development; response to drug; response to insulin stimulus; ruffle assembly" IPR005135; IPR000300; IPR001660; IPR013761; IPR021129; IPR000980; "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)" Inppl1 Ship2 Rattus norvegicus (Rat) TR42586_c1_g1_i6 O15357 SHIP2_HUMAN 2.00E-174 GO:0005794; GO:0007015; GO:0007420; GO:0007155; GO:0005856; GO:0005829; GO:0001958; GO:0006897; GO:0030175; GO:0006006; GO:0043647; GO:0032957; GO:0004445; GO:0030027; GO:0008156; GO:0043407; GO:0008285; GO:0010629; GO:0046627; GO:0043569; GO:0010977; GO:0010642; GO:0006661; GO:0046856; GO:0005547; GO:0005886; GO:0009791; GO:0042493; GO:0032868; GO:0097178 P56945; Q8IV36; Q15811-2; Q9BX66; O60504-1 "Golgi apparatus; actin filament organization; brain development; cell adhesion; cytoskeleton; cytosol; endochondral ossification; endocytosis; filopodium; glucose metabolic process; inositol phosphate metabolic process; inositol trisphosphate metabolic process; inositol-polyphosphate 5-phosphatase activity; lamellipodium; negative regulation of DNA replication; negative regulation of MAP kinase activity; negative regulation of cell proliferation; negative regulation of gene expression; negative regulation of insulin receptor signaling pathway; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of neuron projection development; negative regulation of platelet-derived growth factor receptor signaling pathway; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; phosphatidylinositol-3,4,5-trisphosphate binding; plasma membrane; post-embryonic development; response to drug; response to insulin stimulus; ruffle assembly" IPR005135; IPR000300; IPR001660; IPR013761; IPR021129; IPR000980; "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)" INPPL1 SHIP2 Homo sapiens (Human) TR42586_c1_g1_i7 Q9WVR3 SHIP2_RAT 3.00E-173 GO:0005794; GO:0007015; GO:0007420; GO:0007155; GO:0005856; GO:0005829; GO:0001958; GO:0006897; GO:0030175; GO:0006006; GO:0032957; GO:0004445; GO:0030027; GO:0008156; GO:0043407; GO:0008285; GO:0010629; GO:0046627; GO:0043569; GO:0010977; GO:0010642; GO:0006661; GO:0046856; GO:0005547; GO:0005886; GO:0009791; GO:0042493; GO:0032868; GO:0097178 "Golgi apparatus; actin filament organization; brain development; cell adhesion; cytoskeleton; cytosol; endochondral ossification; endocytosis; filopodium; glucose metabolic process; inositol trisphosphate metabolic process; inositol-polyphosphate 5-phosphatase activity; lamellipodium; negative regulation of DNA replication; negative regulation of MAP kinase activity; negative regulation of cell proliferation; negative regulation of gene expression; negative regulation of insulin receptor signaling pathway; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of neuron projection development; negative regulation of platelet-derived growth factor receptor signaling pathway; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; phosphatidylinositol-3,4,5-trisphosphate binding; plasma membrane; post-embryonic development; response to drug; response to insulin stimulus; ruffle assembly" IPR005135; IPR000300; IPR001660; IPR013761; IPR021129; IPR000980; "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)" Inppl1 Ship2 Rattus norvegicus (Rat) TR42586_c1_g1_i8 P00522 ABL_DROME 5.00E-08 GO:0005524; GO:0045179; GO:0030424; GO:0016199; GO:0005911; GO:0007417; GO:0007303; GO:0005829; GO:0007391; GO:0003382; GO:0019897; GO:0008045; GO:0005927; GO:0045886; GO:0001764; GO:0004715; GO:0003402; GO:0008064; GO:0008360; GO:0032880; GO:0031647; GO:0007370 Q8T4F7; P16621 "ATP binding; apical cortex; axon; axon midline choice point recognition; cell-cell junction; central nervous system development; cytoplasmic transport, nurse cell to oocyte; cytosol; dorsal closure; epithelial cell morphogenesis; extrinsic to plasma membrane; motor neuron axon guidance; muscle tendon junction; negative regulation of synaptic growth at neuromuscular junction; neuron migration; non-membrane spanning protein tyrosine kinase activity; planar cell polarity pathway involved in axis elongation; regulation of actin polymerization or depolymerization; regulation of cell shape; regulation of protein localization; regulation of protein stability; ventral furrow formation" IPR015015; IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase Abl (EC 2.7.10.2) (D-ash) (Protein abelson) Abl ABL-1 Dash CG4032 Drosophila melanogaster (Fruit fly) TR42586_c1_g1_i9 Q9WVR3 SHIP2_RAT 8.00E-41 GO:0005794; GO:0007015; GO:0007420; GO:0007155; GO:0005856; GO:0005829; GO:0001958; GO:0006897; GO:0030175; GO:0006006; GO:0032957; GO:0004445; GO:0030027; GO:0008156; GO:0043407; GO:0008285; GO:0010629; GO:0046627; GO:0043569; GO:0010977; GO:0010642; GO:0006661; GO:0046856; GO:0005547; GO:0005886; GO:0009791; GO:0042493; GO:0032868; GO:0097178 "Golgi apparatus; actin filament organization; brain development; cell adhesion; cytoskeleton; cytosol; endochondral ossification; endocytosis; filopodium; glucose metabolic process; inositol trisphosphate metabolic process; inositol-polyphosphate 5-phosphatase activity; lamellipodium; negative regulation of DNA replication; negative regulation of MAP kinase activity; negative regulation of cell proliferation; negative regulation of gene expression; negative regulation of insulin receptor signaling pathway; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of neuron projection development; negative regulation of platelet-derived growth factor receptor signaling pathway; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; phosphatidylinositol-3,4,5-trisphosphate binding; plasma membrane; post-embryonic development; response to drug; response to insulin stimulus; ruffle assembly" IPR005135; IPR000300; IPR001660; IPR013761; IPR021129; IPR000980; "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)" Inppl1 Ship2 Rattus norvegicus (Rat) TR42588_c0_g1_i1 Q09820 RENT1_SCHPO 3.00E-13 GO:0005524; GO:0004004; GO:0003677; GO:0002184; GO:0005829; GO:0000184; GO:0008270 "ATP binding; ATP-dependent RNA helicase activity; DNA binding; cytoplasmic translational termination; cytosol; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; zinc ion binding" IPR003593; IPR014001; IPR027417; IPR018999; ATP-dependent helicase upf1 (EC 3.6.4.-) (Nonsense-mediated mRNA decay protein upf1) (Regulator of nonsense transcripts 1 homolog) (Up-frameshift suppressor 1) upf1 SPAC16C9.06c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42588_c0_g1_i2 O60306 AQR_HUMAN 0 GO:0071013; GO:0000398; GO:0097157 Q96NB3 "catalytic step 2 spliceosome; mRNA splicing, via spliceosome; pre-mRNA intronic binding" IPR024860; IPR026300; IPR027417; Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160) AQR KIAA0560 Homo sapiens (Human) TR42588_c0_g1_i3 Q8R151 ZNFX1_MOUSE 6.00E-19 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR4259_c1_g1_i1 Q9UPQ7 PZRN3_HUMAN 1.00E-11 GO:0031594; GO:0007528; GO:0004842; GO:0008270 neuromuscular junction; neuromuscular junction development; ubiquitin-protein ligase activity; zinc ion binding IPR001478; IPR013323; IPR008974; IPR001841; IPR013083; IPR017907; IPR001293; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase PDZRN3 (EC 6.3.2.-) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) PDZRN3 KIAA1095 LNX3 SEMCAP3 Homo sapiens (Human) TR42590_c5_g1_i2 F7C1E2 SARAF_XENTR 2.00E-53 GO:0030176; GO:2001256; GO:0015279 integral to endoplasmic reticulum membrane; regulation of store-operated calcium entry; store-operated calcium channel activity IPR009567; Store-operated calcium entry-associated regulatory factor (SARAF) (SOCE-associated regulatory factor) (Transmembrane protein 66) tmem66 saraf Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42590_c5_g1_i4 F7C1E2 SARAF_XENTR 3.00E-53 GO:0030176; GO:2001256; GO:0015279 integral to endoplasmic reticulum membrane; regulation of store-operated calcium entry; store-operated calcium channel activity IPR009567; Store-operated calcium entry-associated regulatory factor (SARAF) (SOCE-associated regulatory factor) (Transmembrane protein 66) tmem66 saraf Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42592_c0_g5_i1 Q8K0C9 GMDS_MOUSE 0 GO:0042351; GO:0008446; GO:0019673; GO:0070401; GO:0007219; GO:0005622 "'de novo' GDP-L-fucose biosynthetic process; GDP-mannose 4,6-dehydratase activity; GDP-mannose metabolic process; NADP+ binding; Notch signaling pathway; intracellular" IPR001509; IPR006368; IPR016040; Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2. "GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD)" Gmds Mus musculus (Mouse) TR42592_c0_g5_i3 Q8K0C9 GMDS_MOUSE 0 GO:0042351; GO:0008446; GO:0019673; GO:0070401; GO:0007219; GO:0005622 "'de novo' GDP-L-fucose biosynthetic process; GDP-mannose 4,6-dehydratase activity; GDP-mannose metabolic process; NADP+ binding; Notch signaling pathway; intracellular" IPR001509; IPR006368; IPR016040; Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2. "GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD)" Gmds Mus musculus (Mouse) TR42593_c0_g1_i1 O17582 SPR4_CAEEL 8.00E-15 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; Suppressor of presenilin protein 4 spr-4 C09H6.1 Caenorhabditis elegans TR42593_c0_g1_i2 O17582 SPR4_CAEEL 8.00E-15 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; Suppressor of presenilin protein 4 spr-4 C09H6.1 Caenorhabditis elegans TR42594_c1_g5_i1 P48416 CP10_LYMST 3.00E-53 GO:0020037; GO:0005506; GO:0004497; GO:0016705 "heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Cytochrome P450 10 (EC 1.14.-.-) (CYPX) CYP10 Lymnaea stagnalis (Great pond snail) TR42594_c1_g5_i3 Q02318 CP27A_HUMAN 3.00E-22 GO:0006699; GO:0036378; GO:0047749; GO:0031073; GO:0008203; GO:0020037; GO:0005506; GO:0005743; GO:0005759; GO:0008395; GO:0016125; GO:0030343; GO:0006805 bile acid biosynthetic process; calcitriol biosynthetic process from calciol; cholestanetriol 26-monooxygenase activity; cholesterol 26-hydroxylase activity; cholesterol metabolic process; heme binding; iron ion binding; mitochondrial inner membrane; mitochondrial matrix; steroid hydroxylase activity; sterol metabolic process; vitamin D3 25-hydroxylase activity; xenobiotic metabolic process IPR001128; IPR017972; IPR002401; Hormone biosynthesis; cholecalciferol biosynthesis. "Sterol 26-hydroxylase, mitochondrial (EC 1.14.13.15) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase) (Cytochrome P-450C27/25) (Cytochrome P450 27) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase)" CYP27A1 CYP27 Homo sapiens (Human) TR42595_c2_g1_i1 A2AHL1 ANO3_MOUSE 0 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR007632; Anoctamin-3 (Transmembrane protein 16C) Ano3 Tmem16c Mus musculus (Mouse) TR42595_c2_g1_i4 A6QLE6 ANO4_BOVIN 0 GO:0016021; GO:0005622; GO:0006810 integral to membrane; intracellular; transport IPR007632; Anoctamin-4 (Transmembrane protein 16D) ANO4 TMEM16D Bos taurus (Bovine) TR42595_c2_g1_i5 A6QLE6 ANO4_BOVIN 0 GO:0016021; GO:0005622; GO:0006810 integral to membrane; intracellular; transport IPR007632; Anoctamin-4 (Transmembrane protein 16D) ANO4 TMEM16D Bos taurus (Bovine) TR42596_c0_g1_i1 Q80YE4 LMTK1_MOUSE 1.00E-61 GO:0005524; GO:0032482; GO:0006915; GO:0044295; GO:0007420; GO:0030425; GO:0005783; GO:0016021; GO:0030517; GO:0051402; GO:0038083; GO:0048471; GO:0046777; GO:0004674; GO:0004713; GO:0055037 ATP binding; Rab protein signal transduction; apoptotic process; axonal growth cone; brain development; dendrite; endoplasmic reticulum; integral to membrane; negative regulation of axon extension; neuron apoptotic process; peptidyl-tyrosine autophosphorylation; perinuclear region of cytoplasm; protein autophosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; recycling endosome IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (Lemur tyrosine kinase 1) Aatk Aatyk Kiaa0641 Lmr1 Lmtk1 Mus musculus (Mouse) TR42596_c0_g1_i2 Q62838 MUSK_RAT 2.00E-26 GO:0005524; GO:0030154; GO:0030054; GO:0042995; GO:0090102; GO:0009897; GO:0016021; GO:0060291; GO:0007613; GO:0010629; GO:0031594; GO:0007528; GO:0010628; GO:0050731; GO:0045887; GO:0032224; GO:0045211; GO:0046777; GO:0004713; GO:0043113; GO:0048678; GO:0051602; GO:0014850; GO:0060041; GO:0004714 "ATP binding; cell differentiation; cell junction; cell projection; cochlea development; external side of plasma membrane; integral to membrane; long-term synaptic potentiation; memory; negative regulation of gene expression; neuromuscular junction; neuromuscular junction development; positive regulation of gene expression; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of synaptic growth at neuromuscular junction; positive regulation of synaptic transmission, cholinergic; postsynaptic membrane; protein autophosphorylation; protein tyrosine kinase activity; receptor clustering; response to axon injury; response to electrical stimulus; response to muscle activity; retina development in camera-type eye; transmembrane receptor protein tyrosine kinase activity" IPR020067; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; "Muscle, skeletal receptor tyrosine protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)" Musk Rattus norvegicus (Rat) TR42596_c0_g1_i4 Q8AXY6 MUSK_CHICK 6.00E-43 GO:0005524; GO:0030154; GO:0030054; GO:0016021; GO:0007275; GO:0018108; GO:0005886; GO:0045211; GO:0008582; GO:0004714 ATP binding; cell differentiation; cell junction; integral to membrane; multicellular organismal development; peptidyl-tyrosine phosphorylation; plasma membrane; postsynaptic membrane; regulation of synaptic growth at neuromuscular junction; transmembrane receptor protein tyrosine kinase activity IPR020067; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000001; IPR013806; IPR018056; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; "Muscle, skeletal receptor tyrosine protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)" MUSK Gallus gallus (Chicken) TR42596_c0_g1_i5 Q80YE4 LMTK1_MOUSE 9.00E-62 GO:0005524; GO:0032482; GO:0006915; GO:0044295; GO:0007420; GO:0030425; GO:0005783; GO:0016021; GO:0030517; GO:0051402; GO:0038083; GO:0048471; GO:0046777; GO:0004674; GO:0004713; GO:0055037 ATP binding; Rab protein signal transduction; apoptotic process; axonal growth cone; brain development; dendrite; endoplasmic reticulum; integral to membrane; negative regulation of axon extension; neuron apoptotic process; peptidyl-tyrosine autophosphorylation; perinuclear region of cytoplasm; protein autophosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; recycling endosome IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (Lemur tyrosine kinase 1) Aatk Aatyk Kiaa0641 Lmr1 Lmtk1 Mus musculus (Mouse) TR42596_c0_g1_i6 Q80YE4 LMTK1_MOUSE 3.00E-62 GO:0005524; GO:0032482; GO:0006915; GO:0044295; GO:0007420; GO:0030425; GO:0005783; GO:0016021; GO:0030517; GO:0051402; GO:0038083; GO:0048471; GO:0046777; GO:0004674; GO:0004713; GO:0055037 ATP binding; Rab protein signal transduction; apoptotic process; axonal growth cone; brain development; dendrite; endoplasmic reticulum; integral to membrane; negative regulation of axon extension; neuron apoptotic process; peptidyl-tyrosine autophosphorylation; perinuclear region of cytoplasm; protein autophosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; recycling endosome IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (Lemur tyrosine kinase 1) Aatk Aatyk Kiaa0641 Lmr1 Lmtk1 Mus musculus (Mouse) TR42596_c0_g1_i7 Q8AXY6 MUSK_CHICK 6.00E-43 GO:0005524; GO:0030154; GO:0030054; GO:0016021; GO:0007275; GO:0018108; GO:0005886; GO:0045211; GO:0008582; GO:0004714 ATP binding; cell differentiation; cell junction; integral to membrane; multicellular organismal development; peptidyl-tyrosine phosphorylation; plasma membrane; postsynaptic membrane; regulation of synaptic growth at neuromuscular junction; transmembrane receptor protein tyrosine kinase activity IPR020067; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000001; IPR013806; IPR018056; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; "Muscle, skeletal receptor tyrosine protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)" MUSK Gallus gallus (Chicken) TR42596_c0_g1_i8 P11681 ABL_CALVI 3.00E-09 GO:0005524; GO:0005737; GO:0004715; GO:0018108 ATP binding; cytoplasm; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation IPR011009; IPR000719; IPR001245; IPR008266; Tyrosine-protein kinase ABL (EC 2.7.10.2) (Fragment) ABL Calliphora vicina (Blue blowfly) (Calliphora erythrocephala) TR42597_c4_g1_i1 Q96C10 DHX58_HUMAN 8.00E-14 GO:0005524; GO:0003677; GO:0005737; GO:0051607; GO:0003725; GO:0004386; GO:0045087; GO:0019048; GO:0039534; GO:0039536; GO:0045824; GO:0032480; GO:1900245; GO:1900246; GO:0032481; GO:0009615; GO:0003727; GO:0008270 Q9UKV8; Q7L2E3; Q9UPY3; P19525; P56537; O15226; P11207; P30927; Q9EMA9; Q9NUL3 ATP binding; DNA binding; cytoplasm; defense response to virus; double-stranded RNA binding; helicase activity; innate immune response; modulation by virus of host morphology or physiology; negative regulation of MDA-5 signaling pathway; negative regulation of RIG-I signaling pathway; negative regulation of innate immune response; negative regulation of type I interferon production; positive regulation of MDA-5 signaling pathway; positive regulation of RIG-I signaling pathway; positive regulation of type I interferon production; response to virus; single-stranded RNA binding; zinc ion binding IPR006935; IPR014001; IPR001650; IPR027417; IPR021673; Probable ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (Probable ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR) DHX58 D11LGP2E LGP2 Homo sapiens (Human) TR42597_c4_g2_i1 Q8IY21 DDX60_HUMAN 8.00E-06 GO:0005524; GO:0008026; GO:0005737; GO:0051607; GO:0003690; GO:0003725; GO:0045087; GO:1900245; GO:1900246; GO:0009615; GO:0003727 ATP binding; ATP-dependent helicase activity; cytoplasm; defense response to virus; double-stranded DNA binding; double-stranded RNA binding; innate immune response; positive regulation of MDA-5 signaling pathway; positive regulation of RIG-I signaling pathway; response to virus; single-stranded RNA binding IPR011545; IPR014001; IPR001650; IPR027417; Probable ATP-dependent RNA helicase DDX60 (EC 3.6.4.13) (DEAD box protein 60) DDX60 Homo sapiens (Human) TR42597_c4_g2_i2 P84634 DCL4_ARATH 1.00E-13 GO:0005524; GO:0008026; GO:0006353; GO:0003723; GO:0010216; GO:0046872; GO:0090305; GO:0005634; GO:0010599; GO:0010267; GO:0004525; GO:0010050; GO:0009616 "ATP binding; ATP-dependent helicase activity; DNA-dependent transcription, termination; RNA binding; maintenance of DNA methylation; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleus; production of lsiRNA involved in RNA interference; production of ta-siRNAs involved in RNA interference; ribonuclease III activity; vegetative phase change; virus induced gene silencing" IPR005034; IPR011545; IPR014720; IPR014001; IPR001650; IPR027417; IPR003100; IPR000999; Dicer-like protein 4 (EC 3.1.26.-) DCL4 At5g20320 F5O24.210 Arabidopsis thaliana (Mouse-ear cress) TR42597_c4_g2_i4 Q9BYX4 IFIH1_HUMAN 5.00E-49 GO:0005524; GO:0003677; GO:0039528; GO:0005829; GO:0009597; GO:0003725; GO:0004386; GO:0045087; GO:0019048; GO:0032480; GO:0005634; GO:0032727; GO:0032728; GO:0016925; GO:0042981; GO:0034344; GO:0043021; GO:0003727; GO:0008270 Q7Z434; P11207; P30927; Q9EMA9; P04487 ATP binding; DNA binding; cytoplasmic pattern recognition receptor signaling pathway in response to virus; cytosol; detection of virus; double-stranded RNA binding; helicase activity; innate immune response; modulation by virus of host morphology or physiology; negative regulation of type I interferon production; nucleus; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; protein sumoylation; regulation of apoptotic process; regulation of type III interferon production; ribonucleoprotein complex binding; single-stranded RNA binding; zinc ion binding IPR001315; IPR011029; IPR006935; IPR014001; IPR001650; IPR027417; IPR021673; Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116) IFIH1 MDA5 RH116 Homo sapiens (Human) TR42597_c4_g3_i1 Q4WVE3 DCL1_ASPFU 2.00E-09 GO:0005524; GO:0003677; GO:0003723; GO:0006396; GO:0051607; GO:0004386; GO:0046872; GO:0050688; GO:0004525 ATP binding; DNA binding; RNA binding; RNA processing; defense response to virus; helicase activity; metal ion binding; regulation of defense response to virus; ribonuclease III activity IPR005034; IPR006935; IPR014001; IPR001650; IPR027417; IPR000909; IPR000999; Dicer-like protein 1 [Includes: Endoribonuclease dcl1 (EC 3.1.26.-); ATP-dependent helicase dcl1 (EC 3.6.4.-)] dcl1 AFUA_5G11790 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) TR42598_c2_g1_i1 F1NBT0 STK10_CHICK 4.00E-89 GO:0005524; GO:0007049; GO:0005886; GO:0046777; GO:0042803; GO:0004674; GO:2000401 ATP binding; cell cycle; plasma membrane; protein autophosphorylation; protein homodimerization activity; protein serine/threonine kinase activity; regulation of lymphocyte migration IPR011009; IPR022165; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase 10 (EC 2.7.11.1) STK10 Gallus gallus (Chicken) TR42598_c2_g4_i4 O55092 SLK_CAVPO 8.00E-08 GO:0005524; GO:0006915; GO:0005737; GO:0046777; GO:0042803; GO:0004674 ATP binding; apoptotic process; cytoplasm; protein autophosphorylation; protein homodimerization activity; protein serine/threonine kinase activity IPR011009; IPR022165; IPR000719; IPR017441; IPR002290; IPR008271; IPR001943; STE20-like serine/threonine-protein kinase (STE20-like kinase) (EC 2.7.11.1) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) SLK Cavia porcellus (Guinea pig) TR42598_c2_g4_i7 O55092 SLK_CAVPO 2.00E-07 GO:0005524; GO:0006915; GO:0005737; GO:0046777; GO:0042803; GO:0004674 ATP binding; apoptotic process; cytoplasm; protein autophosphorylation; protein homodimerization activity; protein serine/threonine kinase activity IPR011009; IPR022165; IPR000719; IPR017441; IPR002290; IPR008271; IPR001943; STE20-like serine/threonine-protein kinase (STE20-like kinase) (EC 2.7.11.1) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) SLK Cavia porcellus (Guinea pig) TR42598_c2_g6_i1 O55092 SLK_CAVPO 4.00E-33 GO:0005524; GO:0006915; GO:0005737; GO:0046777; GO:0042803; GO:0004674 ATP binding; apoptotic process; cytoplasm; protein autophosphorylation; protein homodimerization activity; protein serine/threonine kinase activity IPR011009; IPR022165; IPR000719; IPR017441; IPR002290; IPR008271; IPR001943; STE20-like serine/threonine-protein kinase (STE20-like kinase) (EC 2.7.11.1) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) SLK Cavia porcellus (Guinea pig) TR42599_c2_g3_i1 Q8IV38 ANKY2_HUMAN 1.00E-121 GO:0005929; GO:0046872 cilium; metal ion binding IPR002110; IPR020683; IPR002893; Ankyrin repeat and MYND domain-containing protein 2 ANKMY2 Homo sapiens (Human) TR42599_c2_g3_i2 Q54HW1 PSD10_DICDI 2.00E-10 IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) psmD10 DDB_G0289189 Dictyostelium discoideum (Slime mold) TR42599_c2_g3_i3 Q8NFD2 ANKK1_HUMAN 1.00E-11 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR001245; IPR008271; Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) TR42600_c1_g1_i1 Q20745 UNC84_CAEEL 2.00E-38 GO:0005737; GO:0005856; GO:0016021; GO:0040011; GO:0007399; GO:0005637; GO:0007097; GO:0018991; GO:0030334; GO:0040025 cytoplasm; cytoskeleton; integral to membrane; locomotion; nervous system development; nuclear inner membrane; nuclear migration; oviposition; regulation of cell migration; vulval development IPR012919; Nuclear migration and anchoring protein unc-84 (Uncoordinated protein 84) unc-84 F54B11.3 Caenorhabditis elegans TR42600_c1_g1_i2 O94901 SUN1_HUMAN 5.00E-74 GO:0034993; GO:0002080; GO:0090286; GO:0005639; GO:0006998; GO:0090292; GO:0031965 Q8NF91-1; Q8WXH0-1 SUN-KASH complex; acrosomal membrane; cytoskeletal anchoring at nuclear membrane; integral to nuclear inner membrane; nuclear envelope organization; nuclear matrix anchoring at nuclear membrane; nuclear membrane IPR012919; IPR018539; SUN domain-containing protein 1 (Protein unc-84 homolog A) (Sad1/unc-84 protein-like 1) SUN1 KIAA0810 UNC84A Homo sapiens (Human) TR42600_c1_g1_i5 O94901 SUN1_HUMAN 2.00E-72 GO:0034993; GO:0002080; GO:0090286; GO:0005639; GO:0006998; GO:0090292; GO:0031965 Q8NF91-1; Q8WXH0-1 SUN-KASH complex; acrosomal membrane; cytoskeletal anchoring at nuclear membrane; integral to nuclear inner membrane; nuclear envelope organization; nuclear matrix anchoring at nuclear membrane; nuclear membrane IPR012919; IPR018539; SUN domain-containing protein 1 (Protein unc-84 homolog A) (Sad1/unc-84 protein-like 1) SUN1 KIAA0810 UNC84A Homo sapiens (Human) TR42603_c0_g1_i1 D3ZVP7 ZFY21_RAT 2.00E-41 GO:0016023; GO:0005768; GO:0005925; GO:0046872 cytoplasmic membrane-bounded vesicle; endosome; focal adhesion; metal ion binding IPR000306; IPR017455; IPR011011; IPR013083; Zinc finger FYVE domain-containing protein 21 Zfyve21 Rattus norvegicus (Rat) TR42604_c1_g2_i1 Q6MG64 VWA7_RAT 2.00E-39 GO:0005576 extracellular region IPR002035; von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 G7c Rattus norvegicus (Rat) TR42604_c1_g2_i2 Q6MG64 VWA7_RAT 8.00E-40 GO:0005576 extracellular region IPR002035; von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 G7c Rattus norvegicus (Rat) TR42605_c2_g2_i2 Q80VI1 TRI56_MOUSE 5.00E-06 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) TR42607_c1_g4_i3 Q68CP9 ARID2_HUMAN 6.00E-138 GO:0003677; GO:0016568; GO:0046872; GO:0006337; GO:0005634; GO:0006355; GO:0006351 Q86U86; P51532; Q12824; Q969G3 "DNA binding; chromatin modification; metal ion binding; nucleosome disassembly; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001606; IPR016024; IPR003150; IPR011991; IPR007087; IPR015880; AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200) ARID2 KIAA1557 Homo sapiens (Human) TR42610_c0_g2_i1 Q9W602 SSRP1_XENLA 3.00E-135 GO:0003677; GO:0006281; GO:0006260; GO:0005694; GO:0005730; GO:0006355; GO:0006351 "DNA binding; DNA repair; DNA replication; chromosome; nucleolus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR013719; IPR009071; IPR011993; IPR000969; IPR024954; FACT complex subunit SSRP1 (DNA unwinding factor 87 kDa subunit) (DUF87) (Facilitates chromatin transcription complex subunit ssrp1) (Structure-specific recognition protein 1) ssrp1 Xenopus laevis (African clawed frog) TR42611_c1_g4_i1 Q9UBC2 EP15R_HUMAN 1.00E-148 GO:0005509; GO:0005905; GO:0006897; GO:0007173; GO:0042059; GO:0005634; GO:0005886 Q969G5 calcium ion binding; coated pit; endocytosis; epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; nucleus; plasma membrane IPR011992; IPR018247; IPR002048; IPR000261; Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) EPS15L1 EPS15R Homo sapiens (Human) TR42611_c1_g4_i2 P42566 EPS15_HUMAN 5.00E-61 GO:0030122; GO:0005509; GO:0008283; GO:0060170; GO:0048268; GO:0005905; GO:0005829; GO:0031901; GO:0032456; GO:0006897; GO:0007173; GO:0043231; GO:0042059; GO:0005886; GO:0015031 Q0JRZ9; Q3UQN2; P16333; Q8WXE9; Q9UMX0 AP-2 adaptor complex; calcium ion binding; cell proliferation; cilium membrane; clathrin coat assembly; coated pit; cytosol; early endosome membrane; endocytic recycling; endocytosis; epidermal growth factor receptor signaling pathway; intracellular membrane-bounded organelle; negative regulation of epidermal growth factor receptor signaling pathway; plasma membrane; protein transport IPR011992; IPR018247; IPR002048; IPR000261; IPR003903; Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) EPS15 AF1P Homo sapiens (Human) TR42612_c1_g3_i2 G3MWR8 MICA3_BOVIN 3.00E-33 GO:0071949; GO:0003779; GO:0030042; GO:0005737; GO:0005856; GO:0006887; GO:0016709; GO:0008270 "FAD binding; actin binding; actin filament depolymerization; cytoplasm; cytoskeleton; exocytosis; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; zinc ion binding" IPR001715; IPR022735; IPR002938; IPR003042; IPR001781; Protein-methionine sulfoxide oxidase MICAL3 (EC 1.14.13.-) (Molecule interacting with CasL protein 3) (MICAL-3) MICAL3 Bos taurus (Bovine) TR42613_c1_g1_i1 Q9UUE1 PYC_SCHPO 0 GO:0005524; GO:0003677; GO:0004075; GO:0005829; GO:0006091; GO:0006094; GO:0046872; GO:0004736 ATP binding; DNA binding; biotin carboxylase activity; cytosol; generation of precursor metabolites and energy; gluconeogenesis; metal ion binding; pyruvate carboxylase activity IPR013785; IPR011761; IPR013815; IPR013816; IPR001882; IPR011764; IPR005482; IPR000089; IPR005481; IPR003379; IPR005479; IPR009057; IPR016185; IPR000891; IPR005930; IPR011054; IPR011053; Carbohydrate biosynthesis; gluconeogenesis. Pyruvate carboxylase (EC 6.4.1.1) (Pyruvic carboxylase) (PCB) pyr1 SPBC17G9.11c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42613_c1_g1_i2 P11498 PYC_HUMAN 0 GO:0005524; GO:0003677; GO:0009374; GO:0004075; GO:0006768; GO:0005829; GO:0006094; GO:0006629; GO:0046872; GO:0005743; GO:0005759; GO:0006107; GO:0004736; GO:0006090 ATP binding; DNA binding; biotin binding; biotin carboxylase activity; biotin metabolic process; cytosol; gluconeogenesis; lipid metabolic process; metal ion binding; mitochondrial inner membrane; mitochondrial matrix; oxaloacetate metabolic process; pyruvate carboxylase activity; pyruvate metabolic process IPR013785; IPR011761; IPR013815; IPR013816; IPR001882; IPR011764; IPR005482; IPR000089; IPR005481; IPR003379; IPR005479; IPR009057; IPR016185; IPR000891; IPR005930; IPR011054; IPR011053; Carbohydrate biosynthesis; gluconeogenesis. "Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)" PC Homo sapiens (Human) TR42614_c1_g1_i1 Q9V3C0 DDX41_DROME 0 GO:0005524; GO:0008026; GO:0003723; GO:0071013; GO:0004386; GO:0000398; GO:0071011; GO:0008270 "ATP binding; ATP-dependent helicase activity; RNA binding; catalytic step 2 spliceosome; helicase activity; mRNA splicing, via spliceosome; precatalytic spliceosome; zinc ion binding" IPR011545; IPR014001; IPR001650; IPR027417; IPR014014; IPR001878; ATP-dependent RNA helicase abstrakt (DEAD box protein abstrakt) (EC 3.6.4.13) abs CG14637 Drosophila melanogaster (Fruit fly) TR42614_c1_g1_i2 Q6FU81 MS116_CANGA 5.00E-18 GO:0005524; GO:0008026; GO:0003723; GO:0008380; GO:0006397; GO:0005759; GO:0006417 ATP binding; ATP-dependent helicase activity; RNA binding; RNA splicing; mRNA processing; mitochondrial matrix; regulation of translation IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; "ATP-dependent RNA helicase MSS116, mitochondrial (EC 3.6.4.13)" MSS116 CAGL0F05577g Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) TR42614_c1_g1_i3 Q9C718 RH20_ARATH 5.00E-89 GO:0005524; GO:0008026; GO:0003723; GO:0005829; GO:0000184; GO:0005634; GO:0006364 "ATP binding; ATP-dependent helicase activity; RNA binding; cytosol; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus; rRNA processing" IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; DEAD-box ATP-dependent RNA helicase 20 (EC 3.6.4.13) RH20 At1g55150 T7N22.9 Arabidopsis thaliana (Mouse-ear cress) TR42615_c0_g1_i1 P37889 FBLN2_MOUSE 2.00E-113 GO:0005509; GO:0050840; GO:0010811; GO:0005578 Q62406-1 calcium ion binding; extracellular matrix binding; positive regulation of cell-substrate adhesion; proteinaceous extracellular matrix IPR000020; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibulin-2 (FIBL-2) Fbln2 Mus musculus (Mouse) TR42616_c1_g1_i2 Q9V4A7 PLXB_DROME 1.00E-41 GO:0016021; GO:0005622; GO:0008045; GO:0035021; GO:0005886; GO:0035025; GO:0004872; GO:0007165 integral to membrane; intracellular; motor neuron axon guidance; negative regulation of Rac protein signal transduction; plasma membrane; positive regulation of Rho protein signal transduction; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-B plexB CG17245 Drosophila melanogaster (Fruit fly) TR42616_c1_g1_i3 Q80UG2 PLXA4_MOUSE 1.00E-62 GO:0021960; GO:0021793; GO:0021610; GO:0021615; GO:0016021; GO:0005622; GO:0005886; GO:0021784; GO:0048841; GO:0050923; GO:0017154; GO:0048485; GO:0021636; GO:0021644 O35464 anterior commissure morphogenesis; chemorepulsion of branchiomotor axon; facial nerve morphogenesis; glossopharyngeal nerve morphogenesis; integral to membrane; intracellular; plasma membrane; postganglionic parasympathetic nervous system development; regulation of axon extension involved in axon guidance; regulation of negative chemotaxis; semaphorin receptor activity; sympathetic nervous system development; trigeminal nerve morphogenesis; vagus nerve morphogenesis IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A4 Plxna4 Kiaa1550 Mus musculus (Mouse) TR42616_c1_g3_i2 O45657 PLX2_CAEEL 3.00E-09 GO:0030154; GO:0031252; GO:0009986; GO:0009792; GO:0016021; GO:0005622; GO:0002119; GO:0005886; GO:0004872; GO:0007165; GO:0045138 cell differentiation; cell leading edge; cell surface; embryo development ending in birth or egg hatching; integral to membrane; intracellular; nematode larval development; plasma membrane; receptor activity; signal transduction; tail tip morphogenesis IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-2 plx-2 K04B12.1 Caenorhabditis elegans TR42616_c1_g4_i1 Q9V4A7 PLXB_DROME 3.00E-20 GO:0016021; GO:0005622; GO:0008045; GO:0035021; GO:0005886; GO:0035025; GO:0004872; GO:0007165 integral to membrane; intracellular; motor neuron axon guidance; negative regulation of Rac protein signal transduction; plasma membrane; positive regulation of Rho protein signal transduction; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-B plexB CG17245 Drosophila melanogaster (Fruit fly) TR42616_c1_g4_i2 Q9QZC2 PLXC1_MOUSE 9.00E-09 GO:0016021; GO:0005622; GO:0007275; GO:0004872; GO:0007165 integral to membrane; intracellular; multicellular organismal development; receptor activity; signal transduction IPR013783; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-C1 (Virus-encoded semaphorin protein receptor) (CD antigen CD232) Plxnc1 Vespr Mus musculus (Mouse) TR42617_c7_g4_i1 Q8MJU1 CASP3_FELCA 5.00E-08 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Felis catus (Cat) (Felis silvestris catus) TR42620_c1_g1_i1 Q5RCW6 RBG1L_PONAB 5.00E-23 GO:0005097; GO:0032851 Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR022164; IPR011993; IPR006020; IPR000195; Rab GTPase-activating protein 1-like RABGAP1L Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42620_c1_g2_i5 A2AWA9 RBGP1_MOUSE 3.00E-46 GO:0005097; GO:0007049; GO:0005829; GO:0005815; GO:0032851 Rab GTPase activator activity; cell cycle; cytosol; microtubule organizing center; positive regulation of Rab GTPase activity IPR022164; IPR011993; IPR006020; IPR000195; Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) Rabgap1 Kiaa4104 Mus musculus (Mouse) TR42620_c1_g8_i1 A2AWA9 RBGP1_MOUSE 0 GO:0005097; GO:0007049; GO:0005829; GO:0005815; GO:0032851 Rab GTPase activator activity; cell cycle; cytosol; microtubule organizing center; positive regulation of Rab GTPase activity IPR022164; IPR011993; IPR006020; IPR000195; Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) Rabgap1 Kiaa4104 Mus musculus (Mouse) TR42621_c0_g1_i1 Q4VXU2 PAP1L_HUMAN 2.00E-06 GO:0003723; GO:0000166 RNA binding; nucleotide binding IPR012677; IPR006515; IPR002004; IPR000504; Polyadenylate-binding protein 1-like PABPC1L C20orf119 Homo sapiens (Human) TR42621_c0_g1_i2 Q14151 SAFB2_HUMAN 1.00E-39 GO:0003677; GO:0003723; GO:0005737; GO:0000166; GO:0005634; GO:0006355; GO:0006351 Itself; P03372; Q9H0R8; Q9GZQ8; Q15424; O60504-2 "DNA binding; RNA binding; cytoplasm; nucleotide binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR012677; IPR000504; IPR003034; Scaffold attachment factor B2 (SAF-B2) SAFB2 KIAA0138 Homo sapiens (Human) TR42622_c2_g1_i3 P10155 RO60_HUMAN 6.00E-154 GO:0003723; GO:0060271; GO:0005737; GO:0046872; GO:0005634; GO:0030529; GO:0006383 Q9UHX1 RNA binding; cilium morphogenesis; cytoplasm; metal ion binding; nucleus; ribonucleoprotein complex; transcription from RNA polymerase III promoter IPR008858; IPR018698; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) TR42624_c4_g1_i2 Q3SYT6 CLGN_BOVIN 2.00E-146 GO:0007339; GO:0005509; GO:0005789; GO:0016021; GO:0005635; GO:0006461; GO:0006457 binding of sperm to zona pellucida; calcium ion binding; endoplasmic reticulum membrane; integral to membrane; nuclear envelope; protein complex assembly; protein folding IPR001580; IPR018124; IPR009033; IPR008985; IPR013320; Calmegin CLGN Bos taurus (Bovine) TR42624_c4_g1_i3 P35564 CALX_MOUSE 6.00E-168 GO:0005509; GO:0072583; GO:0071556; GO:0042470; GO:0006457; GO:0048488 Q8VD37 calcium ion binding; clathrin-mediated endocytosis; integral to lumenal side of endoplasmic reticulum membrane; melanosome; protein folding; synaptic vesicle endocytosis IPR001580; IPR018124; IPR009033; IPR008985; IPR013320; Calnexin Canx Mus musculus (Mouse) TR42625_c0_g1_i1 Q13797 ITA9_HUMAN 9.00E-61 GO:0007411; GO:0009925; GO:0007155; GO:0030198; GO:0008305; GO:0007229; GO:0046872; GO:0030593 axon guidance; basal plasma membrane; cell adhesion; extracellular matrix organization; integrin complex; integrin-mediated signaling pathway; metal ion binding; neutrophil chemotaxis IPR013517; IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha-9 (Integrin alpha-RLC) ITGA9 Homo sapiens (Human) TR42625_c0_g1_i4 Q13797 ITA9_HUMAN 9.00E-61 GO:0007411; GO:0009925; GO:0007155; GO:0030198; GO:0008305; GO:0007229; GO:0046872; GO:0030593 axon guidance; basal plasma membrane; cell adhesion; extracellular matrix organization; integrin complex; integrin-mediated signaling pathway; metal ion binding; neutrophil chemotaxis IPR013517; IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha-9 (Integrin alpha-RLC) ITGA9 Homo sapiens (Human) TR42625_c0_g1_i6 Q00651 ITA4_MOUSE 9.00E-59 GO:0001974; GO:0016477; GO:0005911; GO:0007160; GO:0060710; GO:0009897; GO:0060324; GO:0001968; GO:0007157; GO:0008305; GO:0007229; GO:0007159; GO:0060485; GO:0046872; GO:0061032 blood vessel remodeling; cell migration; cell-cell junction; cell-matrix adhesion; chorio-allantoic fusion; external side of plasma membrane; face development; fibronectin binding; heterophilic cell-cell adhesion; integrin complex; integrin-mediated signaling pathway; leukocyte cell-cell adhesion; mesenchyme development; metal ion binding; visceral serous pericardium development IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (Lymphocyte Peyer patch adhesion molecules subunit alpha) (LPAM subunit alpha) (VLA-4 subunit alpha) (CD antigen CD49d) Itga4 Mus musculus (Mouse) TR42627_c1_g2_i1 Q5GN48 DMD_PIG 0 GO:0005509; GO:0030054; GO:0005737; GO:0005856; GO:0045211; GO:0042383; GO:0008270 calcium ion binding; cell junction; cytoplasm; cytoskeleton; postsynaptic membrane; sarcolemma; zinc ion binding IPR001589; IPR001715; IPR016344; IPR011992; IPR015153; IPR015154; IPR018159; IPR002017; IPR001202; IPR000433; Dystrophin DMD Sus scrofa (Pig) TR42627_c1_g2_i2 Q5GN48 DMD_PIG 0 GO:0005509; GO:0030054; GO:0005737; GO:0005856; GO:0045211; GO:0042383; GO:0008270 calcium ion binding; cell junction; cytoplasm; cytoskeleton; postsynaptic membrane; sarcolemma; zinc ion binding IPR001589; IPR001715; IPR016344; IPR011992; IPR015153; IPR015154; IPR018159; IPR002017; IPR001202; IPR000433; Dystrophin DMD Sus scrofa (Pig) TR42628_c1_g1_i1 O75112 LDB3_HUMAN 3.00E-10 GO:0030018; GO:0005856; GO:0048471; GO:0031143; GO:0045214; GO:0008270 Z disc; cytoskeleton; perinuclear region of cytoplasm; pseudopodium; sarcomere organization; zinc ion binding IPR001478; IPR006643; IPR001781; LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein) LDB3 KIAA0613 ZASP Homo sapiens (Human) TR42628_c1_g1_i2 A1ZA47 ZASP_DROME 2.00E-13 GO:0030018; GO:0015629; GO:0051371; GO:0005927; GO:0030239; GO:0001952; GO:0008270 Z disc; actin cytoskeleton; muscle alpha-actinin binding; muscle tendon junction; myofibril assembly; regulation of cell-matrix adhesion; zinc ion binding IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) TR42629_c1_g1_i4 Q9NZV5 SELN_HUMAN 1.00E-31 GO:0005509; GO:0005789; GO:0005576 P16333 calcium ion binding; endoplasmic reticulum membrane; extracellular region IPR002048; Selenoprotein N (SelN) SEPN1 SELN Homo sapiens (Human) TR42629_c1_g1_i6 Q9NZV5 SELN_HUMAN 4.00E-31 GO:0005509; GO:0005789; GO:0005576 P16333 calcium ion binding; endoplasmic reticulum membrane; extracellular region IPR002048; Selenoprotein N (SelN) SEPN1 SELN Homo sapiens (Human) TR42630_c0_g2_i4 Q5VUJ6 LRCH2_HUMAN 8.00E-44 IPR001715; IPR001611; IPR003591; Leucine-rich repeat and calponin homology domain-containing protein 2 LRCH2 KIAA1495 Homo sapiens (Human) TR42630_c0_g2_i6 P41737 LRCH1_FELCA 3.00E-42 IPR001715; Leucine-rich repeat and calponin homology domain-containing protein 1 (Neuronal protein) (Fragment) Felis catus (Cat) (Felis silvestris catus) TR42630_c0_g3_i1 Q96II8 LRCH3_HUMAN 7.00E-77 GO:0005576 extracellular region IPR001715; IPR001611; Leucine-rich repeat and calponin homology domain-containing protein 3 LRCH3 Homo sapiens (Human) TR42631_c1_g1_i1 P21333 FLNA_HUMAN 0 GO:0034988; GO:0031523; GO:0048365; GO:0017160; GO:0051764; GO:0015629; GO:0031532; GO:0051015; GO:0007195; GO:0005938; GO:0034329; GO:0042384; GO:0051220; GO:0005829; GO:0045022; GO:0001837; GO:0045184; GO:0070062; GO:0001948; GO:0042177; GO:0043433; GO:0005634; GO:0005886; GO:0030168; GO:0002576; GO:0043123; GO:0042993; GO:0042803; GO:0034394; GO:0050821; GO:0043113; GO:0004871; GO:0090307; GO:0005802 Q9WMX2; Q8N264; O95067; P46108; O75369; Q12948; P62993; P05556; P07228; P26010; O14786; P35372; Q86SQ0 Fc-gamma receptor I complex binding; Myb complex; Rac GTPase binding; Ral GTPase binding; actin crosslink formation; actin cytoskeleton; actin cytoskeleton reorganization; actin filament binding; adenylate cyclase-inhibiting dopamine receptor signaling pathway; cell cortex; cell junction assembly; cilium assembly; cytoplasmic sequestering of protein; cytosol; early endosome to late endosome transport; epithelial to mesenchymal transition; establishment of protein localization; extracellular vesicular exosome; glycoprotein binding; negative regulation of protein catabolic process; negative regulation of sequence-specific DNA binding transcription factor activity; nucleus; plasma membrane; platelet activation; platelet degranulation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor import into nucleus; protein homodimerization activity; protein localization to cell surface; protein stabilization; receptor clustering; signal transducer activity; spindle assembly involved in mitosis; trans-Golgi network IPR001589; IPR001715; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) FLNA FLN FLN1 Homo sapiens (Human) TR42631_c1_g1_i2 O75369 FLNB_HUMAN 0 GO:0030018; GO:0003779; GO:0015629; GO:0030036; GO:0005938; GO:0030154; GO:0019221; GO:0007016; GO:0005829; GO:0005925; GO:0016021; GO:0005886; GO:0007519; GO:0001725 Itself; P21333; P62993; P05161; Q13233; Q9Y6R4; P16333; P63000 Z disc; actin binding; actin cytoskeleton; actin cytoskeleton organization; cell cortex; cell differentiation; cytokine-mediated signaling pathway; cytoskeletal anchoring at plasma membrane; cytosol; focal adhesion; integral to membrane; plasma membrane; skeletal muscle tissue development; stress fiber IPR001589; IPR001715; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) FLNB FLN1L FLN3 TABP TAP Homo sapiens (Human) TR42631_c1_g1_i5 P21333 FLNA_HUMAN 0 GO:0034988; GO:0031523; GO:0048365; GO:0017160; GO:0051764; GO:0015629; GO:0031532; GO:0051015; GO:0007195; GO:0005938; GO:0034329; GO:0042384; GO:0051220; GO:0005829; GO:0045022; GO:0001837; GO:0045184; GO:0070062; GO:0001948; GO:0042177; GO:0043433; GO:0005634; GO:0005886; GO:0030168; GO:0002576; GO:0043123; GO:0042993; GO:0042803; GO:0034394; GO:0050821; GO:0043113; GO:0004871; GO:0090307; GO:0005802 Q9WMX2; Q8N264; O95067; P46108; O75369; Q12948; P62993; P05556; P07228; P26010; O14786; P35372; Q86SQ0 Fc-gamma receptor I complex binding; Myb complex; Rac GTPase binding; Ral GTPase binding; actin crosslink formation; actin cytoskeleton; actin cytoskeleton reorganization; actin filament binding; adenylate cyclase-inhibiting dopamine receptor signaling pathway; cell cortex; cell junction assembly; cilium assembly; cytoplasmic sequestering of protein; cytosol; early endosome to late endosome transport; epithelial to mesenchymal transition; establishment of protein localization; extracellular vesicular exosome; glycoprotein binding; negative regulation of protein catabolic process; negative regulation of sequence-specific DNA binding transcription factor activity; nucleus; plasma membrane; platelet activation; platelet degranulation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor import into nucleus; protein homodimerization activity; protein localization to cell surface; protein stabilization; receptor clustering; signal transducer activity; spindle assembly involved in mitosis; trans-Golgi network IPR001589; IPR001715; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) FLNA FLN FLN1 Homo sapiens (Human) TR42633_c4_g4_i4 Q95SX7 RTBS_DROME 3.00E-33 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR42636_c2_g4_i2 Q62901 RERE_RAT 7.00E-115 GO:0016605; GO:0003682; GO:0006338; GO:0000118; GO:0005739; GO:0007275; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "PML body; chromatin binding; chromatin remodeling; histone deacetylase complex; mitochondrion; multicellular organismal development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR002951; IPR001025; IPR000949; IPR009057; IPR001005; IPR017884; IPR000679; Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-related protein) Rere Arp Rattus norvegicus (Rat) TR42636_c2_g4_i4 Q80TZ9 RERE_MOUSE 2.00E-26 GO:0016605; GO:0003682; GO:0006338; GO:0000118; GO:0005739; GO:0007275; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "PML body; chromatin binding; chromatin remodeling; histone deacetylase complex; mitochondrion; multicellular organismal development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR002951; IPR001025; IPR000949; IPR009057; IPR001005; IPR017884; IPR000679; Arginine-glutamic acid dipeptide repeats protein (Atrophin-2) Rere Atr2 Kiaa0458 Mus musculus (Mouse) TR42637_c0_g1_i1 Q7Z3B3 KANL1_HUMAN 6.00E-34 GO:0071339; GO:0043984; GO:0043981; GO:0043982; GO:0000123 Q15834 MLL1 complex; histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase complex IPR026180; KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) KANSL1 KIAA1267 MSL1V1 NSL1 Homo sapiens (Human) TR42637_c0_g1_i2 Q0IHW6 KAL1L_XENTR 9.00E-14 GO:0000123 histone acetyltransferase complex IPR026180; KAT8 regulatory NSL complex subunit 1-like protein kansl1l Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42637_c0_g1_i4 Q7Z3B3 KANL1_HUMAN 3.00E-34 GO:0071339; GO:0043984; GO:0043981; GO:0043982; GO:0000123 Q15834 MLL1 complex; histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase complex IPR026180; KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) KANSL1 KIAA1267 MSL1V1 NSL1 Homo sapiens (Human) TR42637_c0_g1_i6 Q7Z3B3 KANL1_HUMAN 3.00E-34 GO:0071339; GO:0043984; GO:0043981; GO:0043982; GO:0000123 Q15834 MLL1 complex; histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase complex IPR026180; KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) KANSL1 KIAA1267 MSL1V1 NSL1 Homo sapiens (Human) TR42638_c1_g1_i1 Q9WUM3 COR1B_MOUSE 2.00E-178 GO:0015629; GO:0030036; GO:0051015; GO:0005737 actin cytoskeleton; actin cytoskeleton organization; actin filament binding; cytoplasm IPR027340; IPR015505; IPR015048; IPR015049; IPR015943; IPR001680; IPR019775; IPR017986; Coronin-1B (Coronin-2) Coro1b Mus musculus (Mouse) TR42638_c1_g1_i2 Q6QEF8 CORO6_HUMAN 7.00E-177 GO:0015629; GO:0030036; GO:0051015 actin cytoskeleton; actin cytoskeleton organization; actin filament binding IPR027337; IPR015505; IPR015048; IPR015049; IPR015943; IPR001680; IPR019775; IPR017986; Coronin-6 (Coronin-like protein E) (Clipin-E) CORO6 PP1009 PP1782 PP1881 Homo sapiens (Human) TR42638_c1_g1_i3 Q9WUM3 COR1B_MOUSE 8.00E-179 GO:0015629; GO:0030036; GO:0051015; GO:0005737 actin cytoskeleton; actin cytoskeleton organization; actin filament binding; cytoplasm IPR027340; IPR015505; IPR015048; IPR015049; IPR015943; IPR001680; IPR019775; IPR017986; Coronin-1B (Coronin-2) Coro1b Mus musculus (Mouse) TR42638_c1_g1_i4 P31146 COR1A_HUMAN 1.00E-175 GO:0043029; GO:0030036; GO:0005884; GO:0051015; GO:0007015; GO:0006816; GO:0031589; GO:0071353; GO:0030864; GO:0048873; GO:0001772; GO:0045087; GO:0030027; GO:0030595; GO:0051126; GO:0001891; GO:0045335; GO:0030670; GO:0001845; GO:0043548; GO:0050918; GO:0042102; GO:0030335; GO:0042803; GO:0030833; GO:0008360; GO:0032796 P40763 T cell homeostasis; actin cytoskeleton organization; actin filament; actin filament binding; actin filament organization; calcium ion transport; cell-substrate adhesion; cellular response to interleukin-4; cortical actin cytoskeleton; homeostasis of number of cells within a tissue; immunological synapse; innate immune response; lamellipodium; leukocyte chemotaxis; negative regulation of actin nucleation; phagocytic cup; phagocytic vesicle; phagocytic vesicle membrane; phagolysosome assembly; phosphatidylinositol 3-kinase binding; positive chemotaxis; positive regulation of T cell proliferation; positive regulation of cell migration; protein homodimerization activity; regulation of actin filament polymerization; regulation of cell shape; uropod organization IPR027333; IPR015505; IPR015048; IPR015049; IPR015943; IPR001680; IPR019775; IPR017986; Coronin-1A (Coronin-like protein A) (Clipin-A) (Coronin-like protein p57) (Tryptophan aspartate-containing coat protein) (TACO) CORO1A CORO1 Homo sapiens (Human) TR42638_c1_g1_i6 O89053 COR1A_MOUSE 7.00E-172 GO:0043029; GO:0051015; GO:0007015; GO:0006816; GO:0031589; GO:0071353; GO:0030864; GO:0048873; GO:0042802; GO:0001772; GO:0030027; GO:0030595; GO:0051126; GO:0001891; GO:0045335; GO:0030670; GO:0001845; GO:0050918; GO:0042102; GO:0030335; GO:0043234; GO:0030833; GO:0008360; GO:0032796 T cell homeostasis; actin filament binding; actin filament organization; calcium ion transport; cell-substrate adhesion; cellular response to interleukin-4; cortical actin cytoskeleton; homeostasis of number of cells within a tissue; identical protein binding; immunological synapse; lamellipodium; leukocyte chemotaxis; negative regulation of actin nucleation; phagocytic cup; phagocytic vesicle; phagocytic vesicle membrane; phagolysosome assembly; positive chemotaxis; positive regulation of T cell proliferation; positive regulation of cell migration; protein complex; regulation of actin filament polymerization; regulation of cell shape; uropod organization IPR027333; IPR015505; IPR015048; IPR015049; IPR015943; IPR001680; IPR019775; IPR017986; Coronin-1A (Coronin-like protein A) (Clipin-A) (Coronin-like protein p57) (Tryptophan aspartate-containing coat protein) (TACO) Coro1a Coro1 Mus musculus (Mouse) TR42638_c1_g1_i7 Q06440 CORO_YEAST 4.00E-84 GO:0030479; GO:0051666; GO:0051015; GO:0007015; GO:0008017; GO:0007017; GO:0034316; GO:2000601; GO:0030674 "actin cortical patch; actin cortical patch localization; actin filament binding; actin filament organization; microtubule binding; microtubule-based process; negative regulation of Arp2/3 complex-mediated actin nucleation; positive regulation of Arp2/3 complex-mediated actin nucleation; protein binding, bridging" IPR015505; IPR015048; IPR015049; IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Coronin-like protein CRN1 YLR429W L9576.2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42638_c1_g1_i8 Q9WUM3 COR1B_MOUSE 0 GO:0015629; GO:0030036; GO:0051015; GO:0005737 actin cytoskeleton; actin cytoskeleton organization; actin filament binding; cytoplasm IPR027340; IPR015505; IPR015048; IPR015049; IPR015943; IPR001680; IPR019775; IPR017986; Coronin-1B (Coronin-2) Coro1b Mus musculus (Mouse) TR42639_c1_g1_i1 Q8WXX7 AUTS2_HUMAN 6.00E-18 IPR023246; Autism susceptibility gene 2 protein AUTS2 KIAA0442 Homo sapiens (Human) TR42639_c1_g1_i5 Q8WXX7 AUTS2_HUMAN 1.00E-18 IPR023246; Autism susceptibility gene 2 protein AUTS2 KIAA0442 Homo sapiens (Human) TR42639_c1_g1_i7 Q8WXX7 AUTS2_HUMAN 6.00E-19 IPR023246; Autism susceptibility gene 2 protein AUTS2 KIAA0442 Homo sapiens (Human) TR42640_c0_g1_i2 Q6DCZ7 FBP1L_XENLA 2.00E-115 GO:0006914; GO:0005938; GO:0016023; GO:0005856; GO:0006897; GO:0008289; GO:0005886 autophagy; cell cortex; cytoplasmic membrane-bounded vesicle; cytoskeleton; endocytosis; lipid binding; plasma membrane IPR001060; IPR001452; Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1) fnbp1l toca1 Xenopus laevis (African clawed frog) TR42640_c0_g1_i3 Q6DCZ7 FBP1L_XENLA 2.00E-116 GO:0006914; GO:0005938; GO:0016023; GO:0005856; GO:0006897; GO:0008289; GO:0005886 autophagy; cell cortex; cytoplasmic membrane-bounded vesicle; cytoskeleton; endocytosis; lipid binding; plasma membrane IPR001060; IPR001452; Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1) fnbp1l toca1 Xenopus laevis (African clawed frog) TR42640_c0_g1_i7 Q8CJ53 CIP4_MOUSE 5.00E-98 GO:0005794; GO:0005938; GO:0042995; GO:0006897; GO:0008289; GO:0005764; GO:0005874; GO:0001891 Golgi apparatus; cell cortex; cell projection; endocytosis; lipid binding; lysosome; microtubule; phagocytic cup IPR001060; IPR001452; Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10) Trip10 Cip4 Mus musculus (Mouse) TR42640_c0_g1_i8 Q6DCZ7 FBP1L_XENLA 2.00E-116 GO:0006914; GO:0005938; GO:0016023; GO:0005856; GO:0006897; GO:0008289; GO:0005886 autophagy; cell cortex; cytoplasmic membrane-bounded vesicle; cytoskeleton; endocytosis; lipid binding; plasma membrane IPR001060; IPR001452; Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1) fnbp1l toca1 Xenopus laevis (African clawed frog) TR42648_c0_g1_i3 Q91YR7 PRP6_MOUSE 0 GO:0003723; GO:0006403; GO:0071001; GO:0046540; GO:0005682; GO:0050681; GO:0071013; GO:0000398; GO:0016607; GO:0005634; GO:0045944; GO:0043021; GO:0003713 "RNA binding; RNA localization; U4/U6 snRNP; U4/U6 x U5 tri-snRNP complex; U5 snRNP; androgen receptor binding; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nuclear speck; nucleus; positive regulation of transcription from RNA polymerase II promoter; ribonucleoprotein complex binding; transcription coactivator activity" IPR003107; IPR010491; IPR027108; IPR013026; IPR011990; IPR019734; Pre-mRNA-processing factor 6 (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) Prpf6 Mus musculus (Mouse) TR42648_c0_g3_i1 P19735 PRP6_YEAST 2.00E-48 GO:0046540; GO:0000398; GO:0005681 Q06819 "U4/U6 x U5 tri-snRNP complex; mRNA splicing, via spliceosome; spliceosomal complex" IPR003107; IPR010491; IPR027108; IPR013026; IPR011990; IPR019734; Pre-mRNA-splicing factor 6 PRP6 RNA6 YBR055C YBR0508 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42648_c0_g3_i4 Q2KJJ0 PRP6_BOVIN 0 GO:0003723; GO:0006403; GO:0071001; GO:0046540; GO:0005682; GO:0071013; GO:0000398; GO:0016607; GO:0045944; GO:0043021; GO:0003713 "RNA binding; RNA localization; U4/U6 snRNP; U4/U6 x U5 tri-snRNP complex; U5 snRNP; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nuclear speck; positive regulation of transcription from RNA polymerase II promoter; ribonucleoprotein complex binding; transcription coactivator activity" IPR003107; IPR010491; IPR027108; IPR013026; IPR011990; Pre-mRNA-processing factor 6 (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) PRPF6 Bos taurus (Bovine) TR42648_c0_g3_i5 P19735 PRP6_YEAST 2.00E-48 GO:0046540; GO:0000398; GO:0005681 Q06819 "U4/U6 x U5 tri-snRNP complex; mRNA splicing, via spliceosome; spliceosomal complex" IPR003107; IPR010491; IPR027108; IPR013026; IPR011990; IPR019734; Pre-mRNA-splicing factor 6 PRP6 RNA6 YBR055C YBR0508 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42649_c1_g2_i1 P34453 PEX19_CAEEL 4.00E-18 GO:0002119; GO:0005777 Q19766 nematode larval development; peroxisome IPR006708; Putative peroxisomal biogenesis factor 19 (Peroxin-19) prx-19 F54F2.8 Caenorhabditis elegans TR42649_c1_g2_i2 Q8VCI5 PEX19_MOUSE 8.00E-58 GO:0061077; GO:0072321; GO:0005829; GO:0016021; GO:1900131; GO:0005634; GO:0005778; GO:0016559; GO:0016557; GO:0036105; GO:0043234; GO:0045046; GO:0050821 Q64364-1 chaperone-mediated protein folding; chaperone-mediated protein transport; cytosol; integral to membrane; negative regulation of lipid binding; nucleus; peroxisomal membrane; peroxisome fission; peroxisome membrane biogenesis; peroxisome membrane class-1 targeting sequence binding; protein complex; protein import into peroxisome membrane; protein stabilization IPR006708; Peroxisomal biogenesis factor 19 (Peroxin-19) (Peroxisomal farnesylated protein) (PxF) Pex19 Pxf Mus musculus (Mouse) TR42649_c1_g2_i3 Q3SZD1 PEX19_BOVIN 9.00E-58 GO:0061077; GO:0072321; GO:0005829; GO:0016021; GO:1900131; GO:0005634; GO:0005778; GO:0016559; GO:0016557; GO:0036105; GO:0043234; GO:0045046; GO:0050821; GO:0006625 chaperone-mediated protein folding; chaperone-mediated protein transport; cytosol; integral to membrane; negative regulation of lipid binding; nucleus; peroxisomal membrane; peroxisome fission; peroxisome membrane biogenesis; peroxisome membrane class-1 targeting sequence binding; protein complex; protein import into peroxisome membrane; protein stabilization; protein targeting to peroxisome IPR006708; Peroxisomal biogenesis factor 19 (Peroxin-19) (Peroxisomal farnesylated protein) PEX19 PXF Bos taurus (Bovine) TR42649_c1_g2_i5 P34453 PEX19_CAEEL 4.00E-18 GO:0002119; GO:0005777 Q19766 nematode larval development; peroxisome IPR006708; Putative peroxisomal biogenesis factor 19 (Peroxin-19) prx-19 F54F2.8 Caenorhabditis elegans TR42649_c1_g2_i6 Q8VCI5 PEX19_MOUSE 5.00E-60 GO:0061077; GO:0072321; GO:0005829; GO:0016021; GO:1900131; GO:0005634; GO:0005778; GO:0016559; GO:0016557; GO:0036105; GO:0043234; GO:0045046; GO:0050821 Q64364-1 chaperone-mediated protein folding; chaperone-mediated protein transport; cytosol; integral to membrane; negative regulation of lipid binding; nucleus; peroxisomal membrane; peroxisome fission; peroxisome membrane biogenesis; peroxisome membrane class-1 targeting sequence binding; protein complex; protein import into peroxisome membrane; protein stabilization IPR006708; Peroxisomal biogenesis factor 19 (Peroxin-19) (Peroxisomal farnesylated protein) (PxF) Pex19 Pxf Mus musculus (Mouse) TR42649_c1_g2_i7 Q3SZD1 PEX19_BOVIN 8.00E-58 GO:0061077; GO:0072321; GO:0005829; GO:0016021; GO:1900131; GO:0005634; GO:0005778; GO:0016559; GO:0016557; GO:0036105; GO:0043234; GO:0045046; GO:0050821; GO:0006625 chaperone-mediated protein folding; chaperone-mediated protein transport; cytosol; integral to membrane; negative regulation of lipid binding; nucleus; peroxisomal membrane; peroxisome fission; peroxisome membrane biogenesis; peroxisome membrane class-1 targeting sequence binding; protein complex; protein import into peroxisome membrane; protein stabilization; protein targeting to peroxisome IPR006708; Peroxisomal biogenesis factor 19 (Peroxin-19) (Peroxisomal farnesylated protein) PEX19 PXF Bos taurus (Bovine) TR42650_c1_g1_i1 Q8MY85 FGFR2_DUGJA 4.00E-42 GO:0005524; GO:0016021; GO:0018108; GO:0004714 ATP binding; integral to membrane; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity IPR007110; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 2 (DjFgfr2) (FGFR-2) (EC 2.7.10.1) (DjPTK1) FGFR2 Dugesia japonica (Planarian) TR42650_c1_g1_i3 Q91147 FGFR2_NOTVI 6.00E-44 GO:0005524; GO:0005794; GO:0006915; GO:0016023; GO:0048701; GO:0005007; GO:0016021; GO:0018108; GO:0005886; GO:0008284 ATP binding; Golgi apparatus; apoptotic process; cytoplasmic membrane-bounded vesicle; embryonic cranial skeleton morphogenesis; fibroblast growth factor-activated receptor activity; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; positive regulation of cell proliferation IPR028175; IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) FGFR2 Notophthalmus viridescens (Eastern newt) (Triturus viridescens) TR42650_c1_g1_i4 P22455 FGFR4_HUMAN 2.00E-38 GO:0005524; GO:0038095; GO:0061144; GO:0016477; GO:0005783; GO:0005768; GO:0007173; GO:0005576; GO:0017134; GO:0005007; GO:0042593; GO:0008201; GO:0045087; GO:0008286; GO:0005887; GO:0048011; GO:0005634; GO:0001759; GO:0055062; GO:0048015; GO:2000573; GO:0070374; GO:0008284; GO:0048554; GO:0045862; GO:0046777; GO:0070857; GO:2000188; GO:0010715 ATP binding; Fc-epsilon receptor signaling pathway; alveolar secondary septum development; cell migration; endoplasmic reticulum; endosome; epidermal growth factor receptor signaling pathway; extracellular region; fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; glucose homeostasis; heparin binding; innate immune response; insulin receptor signaling pathway; integral to plasma membrane; neurotrophin TRK receptor signaling pathway; nucleus; organ induction; phosphate ion homeostasis; phosphatidylinositol-mediated signaling; positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of cell proliferation; positive regulation of metalloenzyme activity; positive regulation of proteolysis; protein autophosphorylation; regulation of bile acid biosynthetic process; regulation of cholesterol homeostasis; regulation of extracellular matrix disassembly IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334) FGFR4 JTK2 TKF Homo sapiens (Human) TR42650_c1_g1_i5 P30530 UFO_HUMAN 5.00E-31 GO:0005524; GO:0043277; GO:0001974; GO:0048469; GO:0009986; GO:0031668; GO:0035457; GO:0071222; GO:0097028; GO:0007167; GO:0034101; GO:0005615; GO:0021885; GO:0006954; GO:0045087; GO:0005887; GO:0001779; GO:2000669; GO:0032689; GO:0051250; GO:0043524; GO:0032720; GO:0001764; GO:0042698; GO:0006909; GO:0001786; GO:0030168; GO:0001961; GO:0032825; GO:0051897; GO:0043491; GO:0032940; GO:0007283; GO:0034446; GO:0004714; GO:0060068 Q14393; P62993 ATP binding; apoptotic cell clearance; blood vessel remodeling; cell maturation; cell surface; cellular response to extracellular stimulus; cellular response to interferon-alpha; cellular response to lipopolysaccharide; dendritic cell differentiation; enzyme linked receptor protein signaling pathway; erythrocyte homeostasis; extracellular space; forebrain cell migration; inflammatory response; innate immune response; integral to plasma membrane; natural killer cell differentiation; negative regulation of dendritic cell apoptotic process; negative regulation of interferon-gamma production; negative regulation of lymphocyte activation; negative regulation of neuron apoptotic process; negative regulation of tumor necrosis factor production; neuron migration; ovulation cycle; phagocytosis; phosphatidylserine binding; platelet activation; positive regulation of cytokine-mediated signaling pathway; positive regulation of natural killer cell differentiation; positive regulation of protein kinase B signaling cascade; protein kinase B signaling cascade; secretion by cell; spermatogenesis; substrate adhesion-dependent cell spreading; transmembrane receptor protein tyrosine kinase activity; vagina development IPR003961; IPR007110; IPR013783; IPR003599; IPR013106; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) AXL UFO Homo sapiens (Human) TR42650_c1_g1_i7 Q03351 NTRK3_RAT 3.00E-14 GO:0005524; GO:0000139; GO:0000187; GO:0032856; GO:0032148; GO:0071300; GO:0090102; GO:0005887; GO:0042490; GO:0019056; GO:0048712; GO:0060548; GO:0001933; GO:0048665; GO:0001764; GO:0005030; GO:0018108; GO:0005886; GO:2000251; GO:0048691; GO:0030335; GO:0008284; GO:0010628; GO:0033138; GO:0050927; GO:0046777; GO:0048678; GO:0051412; GO:0045471; GO:0004714; GO:0007169 ATP binding; Golgi membrane; activation of MAPK activity; activation of Ras GTPase activity; activation of protein kinase B activity; cellular response to retinoic acid; cochlea development; integral to plasma membrane; mechanoreceptor differentiation; modulation by virus of host transcription; negative regulation of astrocyte differentiation; negative regulation of cell death; negative regulation of protein phosphorylation; neuron fate specification; neuron migration; neurotrophin receptor activity; peptidyl-tyrosine phosphorylation; plasma membrane; positive regulation of actin cytoskeleton reorganization; positive regulation of axon extension involved in regeneration; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; positive regulation of positive chemotaxis; protein autophosphorylation; response to axon injury; response to corticosterone stimulus; response to ethanol; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000483; IPR007110; IPR013783; IPR013098; IPR003599; IPR011009; IPR001611; IPR000372; IPR000719; IPR017441; IPR001245; IPR020446; IPR008266; IPR020635; IPR020777; IPR002011; NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) Ntrk3 Trkc Rattus norvegicus (Rat) TR42650_c1_g1_i8 P42679 MATK_HUMAN 2.00E-36 GO:0005524; GO:0008283; GO:0005829; GO:0016020; GO:0007498; GO:0004715; GO:0005634; GO:0008284; GO:0004713 P04626; P08238 ATP binding; cell proliferation; cytosol; membrane; mesoderm development; non-membrane spanning protein tyrosine kinase activity; nucleus; positive regulation of cell proliferation; protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK) MATK CTK HYL Homo sapiens (Human) TR42651_c0_g2_i2 P46530 NOTC1_DANRE 1.00E-10 GO:0007219; GO:0005509; GO:0007368; GO:0031017; GO:0021986; GO:0055016; GO:0016021; GO:0001840; GO:0048936; GO:0048337; GO:0004872; GO:0042663; GO:0048259; GO:0006355; GO:0021523; GO:0001756; GO:0021531; GO:0006351 "Notch signaling pathway; calcium ion binding; determination of left/right symmetry; exocrine pancreas development; habenula development; hypochord development; integral to membrane; neural plate development; peripheral nervous system neuron axonogenesis; positive regulation of mesodermal cell fate specification; receptor activity; regulation of endodermal cell fate specification; regulation of receptor-mediated endocytosis; regulation of transcription, DNA-dependent; somatic motor neuron differentiation; somitogenesis; spinal cord radial glial cell differentiation; transcription, DNA-dependent" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR009030; IPR019931; IPR008297; IPR022362; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 1 notch1a notch Danio rerio (Zebrafish) (Brachydanio rerio) TR42651_c0_g2_i4 Q6V0I7 FAT4_HUMAN 3.00E-07 GO:0005509; GO:0007156; GO:0016021; GO:0005886 Q9H2K2 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) TR42652_c2_g2_i1 Q8WQA4 EXC4_CAEEL 2.00E-25 GO:0043296; GO:0016324; GO:0005254; GO:0034707; GO:0002064; GO:0005887; GO:0005764; GO:0035150; GO:0005244 apical junction complex; apical plasma membrane; chloride channel activity; chloride channel complex; epithelial cell development; integral to plasma membrane; lysosome; regulation of tube size; voltage-gated ion channel activity IPR010987; IPR012336; Chloride intracellular channel exc-4 (Excretory canal abnormal protein 4) exc-4 Y105E8A.22 Caenorhabditis elegans TR42654_c2_g2_i1 A0JM12 MEG10_XENTR 9.00E-21 GO:0007155; GO:0016021; GO:0006909; GO:0005886; GO:0014719; GO:0014816; GO:0014841 cell adhesion; integral to membrane; phagocytosis; plasma membrane; satellite cell activation; satellite cell differentiation; satellite cell proliferation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42655_c1_g3_i1 Q99MI9 ANM7_CRILO 6.00E-09 GO:0043046; GO:0016277; GO:0030154; GO:0005829; GO:0044020; GO:0005634; GO:0035243; GO:0006349; GO:0006355; GO:0000387; GO:0006351 "DNA methylation involved in gamete generation; [myelin basic protein]-arginine N-methyltransferase activity; cell differentiation; cytosol; histone methyltransferase activity (H4-R3 specific); nucleus; protein-arginine omega-N symmetric methyltransferase activity; regulation of gene expression by genetic imprinting; regulation of transcription, DNA-dependent; spliceosomal snRNP assembly; transcription, DNA-dependent" IPR025799; IPR025801; IPR014644; IPR010456; Protein arginine N-methyltransferase 7 (EC 2.1.1.-) (Histone-arginine N-methyltransferase PRMT7) (EC 2.1.1.125) ([Myelin basic protein]-arginine N-methyltransferase PRMT7) (EC 2.1.1.126) Prmt7 Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster) TR42655_c1_g3_i3 Q28F07 ANM1_XENTR 0 GO:0005829; GO:0044020; GO:0007552; GO:0045653; GO:0022008; GO:0005634; GO:0045893; GO:0031056; GO:0003713; GO:0006351 "cytosol; histone methyltransferase activity (H4-R3 specific); metamorphosis; negative regulation of megakaryocyte differentiation; neurogenesis; nucleus; positive regulation of transcription, DNA-dependent; regulation of histone modification; transcription coactivator activity; transcription, DNA-dependent" IPR025799; IPR025714; Protein arginine N-methyltransferase 1 (EC 2.1.1.-) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 2) (Histone-arginine N-methyltransferase PRMT1) (EC 2.1.1.125) prmt1 hrmt1l2 TGas059i20.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42655_c1_g3_i4 Q6VRB0 ANM1B_XENLA 0 GO:0005829; GO:0044020; GO:0045653; GO:0022008; GO:0005634; GO:0006355; GO:0006351 "cytosol; histone methyltransferase activity (H4-R3 specific); negative regulation of megakaryocyte differentiation; neurogenesis; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025799; IPR025714; Protein arginine N-methyltransferase 1-B (xPRMT1b) (EC 2.1.1.-) (Arginine methyltransferase 1b) (Histone-arginine N-methyltransferase PRMT1-B) (EC 2.1.1.125) prmt1-b prmt1 prmt1b Xenopus laevis (African clawed frog) TR42655_c1_g3_i6 Q6VRB0 ANM1B_XENLA 0 GO:0005829; GO:0044020; GO:0045653; GO:0022008; GO:0005634; GO:0006355; GO:0006351 "cytosol; histone methyltransferase activity (H4-R3 specific); negative regulation of megakaryocyte differentiation; neurogenesis; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025799; IPR025714; Protein arginine N-methyltransferase 1-B (xPRMT1b) (EC 2.1.1.-) (Arginine methyltransferase 1b) (Histone-arginine N-methyltransferase PRMT1-B) (EC 2.1.1.125) prmt1-b prmt1 prmt1b Xenopus laevis (African clawed frog) TR42658_c4_g5_i1 Q64620 PPP6_RAT 0 GO:0007049; GO:0005737; GO:0046872; GO:0006470; GO:0004722 cell cycle; cytoplasm; metal ion binding; protein dephosphorylation; protein serine/threonine phosphatase activity IPR004843; IPR006186; "Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) (Protein phosphatase V) (PP-V) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]" Ppp6c Ppv Rattus norvegicus (Rat) TR42658_c4_g5_i2 P23777 PP1_BRANA 6.00E-77 GO:0046872; GO:0004721 metal ion binding; phosphoprotein phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1 (EC 3.1.3.16) (Fragment) Brassica napus (Rape) TR42659_c0_g2_i1 Q9ULJ7 ANR50_HUMAN 0 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) TR42659_c0_g2_i3 B2RXR6 ANR44_MOUSE 8.00E-67 IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) Ankrd44 Mus musculus (Mouse) TR42659_c0_g2_i4 Q9ULJ7 ANR50_HUMAN 0 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) TR42660_c5_g2_i1 Q2WED0 C3AR_ONCMY 2.00E-09 GO:0004982; GO:0006935; GO:0016021; GO:0005886 N-formyl peptide receptor activity; chemotaxis; integral to membrane; plasma membrane IPR000826; IPR000276; IPR017452; C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R) c3ar1 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR42660_c5_g2_i3 P30975 TLR2_DROME 4.00E-13 GO:0005887; GO:0004995 integral to plasma membrane; tachykinin receptor activity IPR000276; IPR017452; IPR001681; Tachykinin-like peptides receptor 99D (dTKR) Takr99D CG7887 Drosophila melanogaster (Fruit fly) TR42660_c5_g2_i4 Q9N0W7 EDNRB_RABIT 5.00E-07 GO:0004962; GO:0086100; GO:0048484; GO:0016021; GO:0005886; GO:0008217; GO:0042310 endothelin receptor activity; endothelin receptor signaling pathway; enteric nervous system development; integral to membrane; plasma membrane; regulation of blood pressure; vasoconstriction IPR000499; IPR001112; IPR000276; IPR017452; Endothelin B receptor (ET-B) (ET-BR) (Endothelin receptor non-selective type) EDNRB Oryctolagus cuniculus (Rabbit) TR42660_c5_g2_i7 Q9GZQ6 NPFF1_HUMAN 3.00E-09 GO:0016021; GO:0008188; GO:0005886 integral to membrane; neuropeptide receptor activity; plasma membrane IPR000276; IPR017452; IPR005395; IPR005396; Neuropeptide FF receptor 1 (G-protein coupled receptor 147) (RFamide-related peptide receptor OT7T022) NPFFR1 GPR147 NPFF1 Homo sapiens (Human) TR42660_c5_g2_i8 P30975 TLR2_DROME 7.00E-12 GO:0005887; GO:0004995 integral to plasma membrane; tachykinin receptor activity IPR000276; IPR017452; IPR001681; Tachykinin-like peptides receptor 99D (dTKR) Takr99D CG7887 Drosophila melanogaster (Fruit fly) TR42660_c5_g2_i9 P30555 AGTR1_PIG 8.00E-10 GO:0007266; GO:0010698; GO:0001596; GO:0004945; GO:0019722; GO:0060326; GO:0051482; GO:0016021; GO:0001822; GO:0005886; GO:0032270; GO:0010873; GO:0032430; GO:0019229 Rho protein signal transduction; acetyltransferase activator activity; angiotensin type I receptor activity; angiotensin type II receptor activity; calcium-mediated signaling; cell chemotaxis; elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; integral to membrane; kidney development; plasma membrane; positive regulation of cellular protein metabolic process; positive regulation of cholesterol esterification; positive regulation of phospholipase A2 activity; regulation of vasoconstriction IPR000190; IPR000248; IPR000276; IPR017452; Type-1 angiotensin II receptor (Angiotensin II type-1 receptor) (AT1) AGTR1 Sus scrofa (Pig) TR42661_c1_g1_i1 Q55ED1 NAP1_DICDI 9.00E-16 GO:0005737; GO:0042393; GO:0006334; GO:0005634 cytoplasm; histone binding; nucleosome assembly; nucleus IPR002164; Probable nucleosome assembly protein nap1 DDB_G0269290 Dictyostelium discoideum (Slime mold) TR42661_c1_g1_i10 Q924R9 NP1L3_RAT 1.00E-35 GO:0006334; GO:0005634 nucleosome assembly; nucleus IPR002164; Nucleosome assembly protein 1-like 3 Nap1l3 Rattus norvegicus (Rat) TR42661_c1_g1_i12 P28656 NP1L1_MOUSE 8.00E-117 GO:0042470; GO:0006334; GO:0005634 Q9WVS7 melanosome; nucleosome assembly; nucleus IPR002164; Nucleosome assembly protein 1-like 1 (Brain protein DN38) (NAP-1-related protein) Nap1l1 Nrp Mus musculus (Mouse) TR42661_c1_g1_i13 A6NFF2 NP1L6_HUMAN 2.00E-10 GO:0006334; GO:0005634 nucleosome assembly; nucleus IPR002164; Putative nucleosome assembly protein 1-like 6 NAP1L6 Homo sapiens (Human) TR42661_c1_g1_i14 P78920 YGNB_SCHPO 6.00E-43 GO:0005829; GO:0042393; GO:0000790; GO:0006334 cytosol; histone binding; nuclear chromatin; nucleosome assembly IPR002164; Putative nucleosome assembly protein C2D10.11C SPBC2D10.11c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42661_c1_g1_i15 Q924R9 NP1L3_RAT 1.00E-36 GO:0006334; GO:0005634 nucleosome assembly; nucleus IPR002164; Nucleosome assembly protein 1-like 3 Nap1l3 Rattus norvegicus (Rat) TR42661_c1_g1_i16 P28656 NP1L1_MOUSE 2.00E-116 GO:0042470; GO:0006334; GO:0005634 Q9WVS7 melanosome; nucleosome assembly; nucleus IPR002164; Nucleosome assembly protein 1-like 1 (Brain protein DN38) (NAP-1-related protein) Nap1l1 Nrp Mus musculus (Mouse) TR42661_c1_g1_i2 P28656 NP1L1_MOUSE 1.00E-110 GO:0042470; GO:0006334; GO:0005634 Q9WVS7 melanosome; nucleosome assembly; nucleus IPR002164; Nucleosome assembly protein 1-like 1 (Brain protein DN38) (NAP-1-related protein) Nap1l1 Nrp Mus musculus (Mouse) TR42661_c1_g1_i3 Q55ED1 NAP1_DICDI 1.00E-15 GO:0005737; GO:0042393; GO:0006334; GO:0005634 cytoplasm; histone binding; nucleosome assembly; nucleus IPR002164; Probable nucleosome assembly protein nap1 DDB_G0269290 Dictyostelium discoideum (Slime mold) TR42661_c1_g1_i4 Q28EB4 NP1L1_XENTR 2.00E-106 GO:0030154; GO:0030332; GO:0005737; GO:0042393; GO:0006334; GO:0005634; GO:0045944; GO:0060215; GO:0051260; GO:0007283; GO:0006351 "cell differentiation; cyclin binding; cytoplasm; histone binding; nucleosome assembly; nucleus; positive regulation of transcription from RNA polymerase II promoter; primitive hemopoiesis; protein homooligomerization; spermatogenesis; transcription, DNA-dependent" IPR002164; Nucleosome assembly protein 1-like 1 nap1l1 TNeu131c07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42661_c1_g1_i6 Q5U2Z3 NP1L4_RAT 5.00E-104 GO:0006334; GO:0005634 nucleosome assembly; nucleus IPR002164; Nucleosome assembly protein 1-like 4 Nap1l4 Rattus norvegicus (Rat) TR42661_c1_g1_i7 Q794H2 NP1L3_MOUSE 2.00E-39 GO:0005737; GO:0006334; GO:0005634 cytoplasm; nucleosome assembly; nucleus IPR002164; Nucleosome assembly protein 1-like 3 (Brain-specific protein MB20) Nap1l3 Mb20 Mus musculus (Mouse) TR42661_c1_g1_i8 P78920 YGNB_SCHPO 3.00E-24 GO:0005829; GO:0042393; GO:0000790; GO:0006334 cytosol; histone binding; nuclear chromatin; nucleosome assembly IPR002164; Putative nucleosome assembly protein C2D10.11C SPBC2D10.11c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42661_c1_g1_i9 Q2TA40 NP1L4_BOVIN 9.00E-113 GO:0006334; GO:0005634 nucleosome assembly; nucleus IPR002164; Nucleosome assembly protein 1-like 4 NAP1L4 Bos taurus (Bovine) TR42662_c2_g3_i1 B0KWH8 THOC2_CALJA 0 GO:0003723; GO:0008380; GO:0006397; GO:0051028; GO:0005634 RNA binding; RNA splicing; mRNA processing; mRNA transport; nucleus IPR021418; IPR021726; THO complex subunit 2 (Tho2) THOC2 Callithrix jacchus (White-tufted-ear marmoset) TR42662_c2_g3_i2 B0KWH8 THOC2_CALJA 1.00E-109 GO:0003723; GO:0008380; GO:0006397; GO:0051028; GO:0005634 RNA binding; RNA splicing; mRNA processing; mRNA transport; nucleus IPR021418; IPR021726; THO complex subunit 2 (Tho2) THOC2 Callithrix jacchus (White-tufted-ear marmoset) TR42663_c1_g1_i2 Q6P2Q9 PRP8_HUMAN 0 GO:0030623; GO:0005682; GO:0017070; GO:0071013; GO:0000398; GO:0016607; GO:0005654 O75934; Q15029; Q92917; Q15365; Q9UMS4; Q13435; Q15427; O95391; Q96DI7; Q9BRX9; Q96NB3 "U5 snRNA binding; U5 snRNP; U6 snRNA binding; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nuclear speck; nucleoplasm" IPR000555; IPR012591; IPR012592; IPR012984; IPR027652; IPR021983; IPR019581; IPR019580; IPR012337; IPR019582; Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) PRPF8 PRPC8 Homo sapiens (Human) TR42663_c1_g1_i4 Q6P2Q9 PRP8_HUMAN 0 GO:0030623; GO:0005682; GO:0017070; GO:0071013; GO:0000398; GO:0016607; GO:0005654 O75934; Q15029; Q92917; Q15365; Q9UMS4; Q13435; Q15427; O95391; Q96DI7; Q9BRX9; Q96NB3 "U5 snRNA binding; U5 snRNP; U6 snRNA binding; catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nuclear speck; nucleoplasm" IPR000555; IPR012591; IPR012592; IPR012984; IPR027652; IPR021983; IPR019581; IPR019580; IPR012337; IPR019582; Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) PRPF8 PRPC8 Homo sapiens (Human) TR42664_c1_g1_i1 O60341 KDM1A_HUMAN 0 GO:0043426; GO:0050681; GO:0007596; GO:0008283; GO:0003682; GO:0050660; GO:0030851; GO:0032454; GO:0034648; GO:0001701; GO:0030374; GO:0055001; GO:0043392; GO:0043518; GO:0051572; GO:0051573; GO:1902166; GO:0032091; GO:0043433; GO:0000122; GO:0000790; GO:0005654; GO:0016491; GO:0021983; GO:0045648; GO:0046886; GO:0045654; GO:2000179; GO:0051091; GO:2000648; GO:0045944; GO:0010725; GO:0003700; GO:0005667; GO:0044212; GO:0006351 Q99996; Q8IXJ9; P59598; Q6P047; A5D8V7; Q9BXL8; Q8NHQ1; Q12873; Q96EY1; Q8IZU1; Q9BQS8; Q8NEC7; Q9BX10; Q96CS2; O15379; Q9UBX0; Q16695; Q16891; Q8TBB5; Q96JB6; O95983; Q13133; Q8IZS5; Q8IZL8; Q5T6S3; Q03181; P62191; Q9NS23; P50749; Q9UKL0; Q8N6K7; Q9UGK8; Q13435; O15198; O95863; Q96H20; Q96BD6; Q8N4C7 "MRF binding; androgen receptor binding; blood coagulation; cell proliferation; chromatin binding; flavin adenine dinucleotide binding; granulocyte differentiation; histone demethylase activity (H3-K9 specific); histone demethylase activity (H3-dimethyl-K4 specific); in utero embryonic development; ligand-dependent nuclear receptor transcription coactivator activity; muscle cell development; negative regulation of DNA binding; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of histone H3-K4 methylation; negative regulation of histone H3-K9 methylation; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of protein binding; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; nucleoplasm; oxidoreductase activity; pituitary gland development; positive regulation of erythrocyte differentiation; positive regulation of hormone biosynthetic process; positive regulation of megakaryocyte differentiation; positive regulation of neural precursor cell proliferation; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of stem cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of primitive erythrocyte differentiation; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR002937; IPR017366; IPR009057; IPR007526; IPR011991; Lysine-specific histone demethylase 1A (EC 1.-.-.-) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) KDM1A AOF2 KDM1 KIAA0601 LSD1 Homo sapiens (Human) TR42664_c1_g1_i3 Q6QHF9 PAOX_HUMAN 1.00E-14 GO:0052899; GO:0052904; GO:0052903; GO:0005782; GO:0006598; GO:0046592; GO:1901307; GO:0009446; GO:0009447; GO:0044281; GO:0046203; GO:0052902; GO:0046208; GO:0052901; GO:0006805 "N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; peroxisomal matrix; polyamine catabolic process; polyamine oxidase activity; positive regulation of spermidine biosynthetic process; putrescine biosynthetic process; putrescine catabolic process; small molecule metabolic process; spermidine catabolic process; spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity; spermine catabolic process; spermine:oxygen oxidoreductase (spermidine-forming) activity; xenobiotic metabolic process" IPR002937; Amine and polyamine metabolism; spermine metabolism. Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC 1.5.3.13) (Polyamine oxidase) PAOX PAO UNQ1923/PRO4398 Homo sapiens (Human) TR42664_c1_g1_i5 O60341 KDM1A_HUMAN 0 GO:0043426; GO:0050681; GO:0007596; GO:0008283; GO:0003682; GO:0050660; GO:0030851; GO:0032454; GO:0034648; GO:0001701; GO:0030374; GO:0055001; GO:0043392; GO:0043518; GO:0051572; GO:0051573; GO:1902166; GO:0032091; GO:0043433; GO:0000122; GO:0000790; GO:0005654; GO:0016491; GO:0021983; GO:0045648; GO:0046886; GO:0045654; GO:2000179; GO:0051091; GO:2000648; GO:0045944; GO:0010725; GO:0003700; GO:0005667; GO:0044212; GO:0006351 Q99996; Q8IXJ9; P59598; Q6P047; A5D8V7; Q9BXL8; Q8NHQ1; Q12873; Q96EY1; Q8IZU1; Q9BQS8; Q8NEC7; Q9BX10; Q96CS2; O15379; Q9UBX0; Q16695; Q16891; Q8TBB5; Q96JB6; O95983; Q13133; Q8IZS5; Q8IZL8; Q5T6S3; Q03181; P62191; Q9NS23; P50749; Q9UKL0; Q8N6K7; Q9UGK8; Q13435; O15198; O95863; Q96H20; Q96BD6; Q8N4C7 "MRF binding; androgen receptor binding; blood coagulation; cell proliferation; chromatin binding; flavin adenine dinucleotide binding; granulocyte differentiation; histone demethylase activity (H3-K9 specific); histone demethylase activity (H3-dimethyl-K4 specific); in utero embryonic development; ligand-dependent nuclear receptor transcription coactivator activity; muscle cell development; negative regulation of DNA binding; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of histone H3-K4 methylation; negative regulation of histone H3-K9 methylation; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of protein binding; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; nuclear chromatin; nucleoplasm; oxidoreductase activity; pituitary gland development; positive regulation of erythrocyte differentiation; positive regulation of hormone biosynthetic process; positive regulation of megakaryocyte differentiation; positive regulation of neural precursor cell proliferation; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of stem cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of primitive erythrocyte differentiation; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR002937; IPR017366; IPR009057; IPR007526; IPR011991; Lysine-specific histone demethylase 1A (EC 1.-.-.-) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) KDM1A AOF2 KDM1 KIAA0601 LSD1 Homo sapiens (Human) TR42665_c0_g2_i1 Q92621 NU205_HUMAN 0 GO:0005975; GO:0019221; GO:0015758; GO:0051028; GO:0007077; GO:0031965; GO:0034399; GO:0005643; GO:0051292; GO:0000059; GO:0010827; GO:0044281; GO:0017056; GO:0055085; GO:0016032 "carbohydrate metabolic process; cytokine-mediated signaling pathway; glucose transport; mRNA transport; mitotic nuclear envelope disassembly; nuclear membrane; nuclear periphery; nuclear pore; nuclear pore complex assembly; protein import into nucleus, docking; regulation of glucose transport; small molecule metabolic process; structural constituent of nuclear pore; transmembrane transport; viral process" IPR021827; Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) NUP205 C7orf14 KIAA0225 Homo sapiens (Human) TR42665_c0_g2_i2 Q92621 NU205_HUMAN 0 GO:0005975; GO:0019221; GO:0015758; GO:0051028; GO:0007077; GO:0031965; GO:0034399; GO:0005643; GO:0051292; GO:0000059; GO:0010827; GO:0044281; GO:0017056; GO:0055085; GO:0016032 "carbohydrate metabolic process; cytokine-mediated signaling pathway; glucose transport; mRNA transport; mitotic nuclear envelope disassembly; nuclear membrane; nuclear periphery; nuclear pore; nuclear pore complex assembly; protein import into nucleus, docking; regulation of glucose transport; small molecule metabolic process; structural constituent of nuclear pore; transmembrane transport; viral process" IPR021827; Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) NUP205 C7orf14 KIAA0225 Homo sapiens (Human) TR42666_c2_g1_i1 P49657 MNB_DROME 0 GO:0005524; GO:0030154; GO:0007623; GO:0007399; GO:0005634; GO:0008355; GO:0004674; GO:0004712; GO:0007632 ATP binding; cell differentiation; circadian rhythm; nervous system development; nucleus; olfactory learning; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; visual behavior IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase minibrain (EC 2.7.12.1) mnb CG7826 Drosophila melanogaster (Fruit fly) TR42666_c2_g1_i2 P49657 MNB_DROME 0 GO:0005524; GO:0030154; GO:0007623; GO:0007399; GO:0005634; GO:0008355; GO:0004674; GO:0004712; GO:0007632 ATP binding; cell differentiation; circadian rhythm; nervous system development; nucleus; olfactory learning; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; visual behavior IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase minibrain (EC 2.7.12.1) mnb CG7826 Drosophila melanogaster (Fruit fly) TR42666_c2_g1_i3 Q54UA9 CLKA_DICDI 9.00E-35 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Probable serine/threonine-protein kinase clkA (EC 2.7.11.1) (CDC2-like kinase A) clkA DDB_G0281179 Dictyostelium discoideum (Slime mold) TR42669_c0_g2_i2 P15170 ERF3A_HUMAN 0 GO:0000082; GO:0005525; GO:0003924; GO:0005622; GO:0000184; GO:0006479; GO:0003747 P62495; Q92900 "G1/S transition of mitotic cell cycle; GTP binding; GTPase activity; intracellular; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; protein methylation; translation release factor activity" IPR000795; IPR027417; IPR009000; IPR009001; IPR004161; IPR004160; Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (G1 to S phase transition protein 1 homolog) GSPT1 ERF3A Homo sapiens (Human) TR42669_c0_g2_i4 P15170 ERF3A_HUMAN 0 GO:0000082; GO:0005525; GO:0003924; GO:0005622; GO:0000184; GO:0006479; GO:0003747 P62495; Q92900 "G1/S transition of mitotic cell cycle; GTP binding; GTPase activity; intracellular; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; protein methylation; translation release factor activity" IPR000795; IPR027417; IPR009000; IPR009001; IPR004161; IPR004160; Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (G1 to S phase transition protein 1 homolog) GSPT1 ERF3A Homo sapiens (Human) TR42670_c1_g6_i1 Q9Z138 ROR2_MOUSE 0 GO:0005524; GO:0007254; GO:0007223; GO:0060071; GO:0001502; GO:0030154; GO:0030538; GO:0042472; GO:0005887; GO:0090090; GO:0008285; GO:0090263; GO:0030335; GO:0045893; GO:0001756; GO:0004714; GO:0007169 "ATP binding; JNK cascade; Wnt receptor signaling pathway, calcium modulating pathway; Wnt receptor signaling pathway, planar cell polarity pathway; cartilage condensation; cell differentiation; embryonic genitalia morphogenesis; inner ear morphogenesis; integral to plasma membrane; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of cell proliferation; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell migration; positive regulation of transcription, DNA-dependent; somitogenesis; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway" IPR020067; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000001; IPR013806; IPR018056; IPR000719; IPR001245; IPR008266; IPR020635; IPR016247; "Tyrosine-protein kinase transmembrane receptor ROR2 (mROR2) (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2)" Ror2 Mus musculus (Mouse) TR42670_c1_g6_i3 Q19AZ8 THRB_PIG 2.00E-11 GO:0006953; GO:0007596; GO:0005509; GO:0005576; GO:0006508; GO:0004252 acute-phase response; blood coagulation; calcium ion binding; extracellular region; proteolysis; serine-type endopeptidase activity IPR017857; IPR000294; IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR003966; IPR018992; IPR009003; Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] F2 Sus scrofa (Pig) TR42672_c0_g1_i1 Q80T79 CSMD3_MOUSE 8.00E-08 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 3 (CUB and sushi multiple domains protein 3) Csmd3 Kiaa1894 Mus musculus (Mouse) TR42672_c4_g1_i3 P18320 PROF_ANTCR 3.00E-55 GO:0030036; GO:0005737; GO:0005856 actin cytoskeleton organization; cytoplasm; cytoskeleton IPR027310; IPR005455; Profilin Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR42672_c4_g1_i7 P18320 PROF_ANTCR 3.00E-52 GO:0030036; GO:0005737; GO:0005856 actin cytoskeleton organization; cytoplasm; cytoskeleton IPR027310; IPR005455; Profilin Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR42672_c5_g1_i1 Q96PZ7 CSMD1_HUMAN 1.00E-08 GO:0016021 integral to membrane IPR000859; IPR000436; CUB and sushi domain-containing protein 1 (CUB and sushi multiple domains protein 1) CSMD1 KIAA1890 UNQ5952/PRO19863 Homo sapiens (Human) TR42672_c5_g2_i2 Q53RD9 FBLN7_HUMAN 2.00E-09 GO:0005509; GO:0007155; GO:0008201; GO:0005578 calcium ion binding; cell adhesion; heparin binding; proteinaceous extracellular matrix IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR000436; Fibulin-7 (FIBL-7) FBLN7 TM14 Homo sapiens (Human) TR42672_c5_g2_i3 Q70E20 SNED1_MOUSE 2.00E-15 GO:0005509; GO:0007160; GO:0005576 calcium ion binding; cell-matrix adhesion; extracellular region IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003961; IPR009030; IPR013783; IPR003886; IPR000436; "Sushi, nidogen and EGF-like domain-containing protein 1 (Secreted protein SST-3) (Stromal nidogen extracellular matrix protein)" Sned1 Snep Mus musculus (Mouse) TR42672_c5_g2_i5 Q501P1 FBLN7_MOUSE 3.00E-09 GO:0005509; GO:0007155; GO:0008201; GO:0005578 calcium ion binding; cell adhesion; heparin binding; proteinaceous extracellular matrix IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR000436; Fibulin-7 (FIBL-7) (Protein TM14) Fbln7 Tm14 Mus musculus (Mouse) TR42675_c0_g1_i2 Q99M80 PTPRT_MOUSE 5.00E-79 GO:0051393; GO:0045294; GO:0008013; GO:0009986; GO:0007156; GO:0016021; GO:0005886; GO:0004725; GO:0016790; GO:0007169 alpha-actinin binding; alpha-catenin binding; beta-catenin binding; cell surface; homophilic cell adhesion; integral to membrane; plasma membrane; protein tyrosine phosphatase activity; thiolester hydrolase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) TR42675_c0_g1_i3 O73791 TIE2_DANRE 7.00E-11 GO:0005524; GO:0005737; GO:0005856; GO:0005925; GO:0007507; GO:0005887; GO:0018108; GO:0004714; GO:0007169 ATP binding; cytoplasm; cytoskeleton; focal adhesion; heart development; integral to plasma membrane; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR000742; IPR013032; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR011009; IPR000719; IPR017441; IPR001245; IPR018941; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-2 (EC 2.7.10.1) (Tyrosine kinase with Ig and EGF homology domains-2) tie2 tie-2 Danio rerio (Zebrafish) (Brachydanio rerio) TR42675_c0_g1_i4 P28828 PTPRM_MOUSE 2.00E-78 GO:0045296; GO:0005913; GO:0007156; GO:0016021; GO:0030027; GO:0016525; GO:0010596; GO:0001937; GO:0048471; GO:0045909; GO:0042493; GO:0010842; GO:0031290; GO:0005001 cadherin binding; cell-cell adherens junction; homophilic cell adhesion; integral to membrane; lamellipodium; negative regulation of angiogenesis; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; perinuclear region of cytoplasm; positive regulation of vasodilation; response to drug; retina layer formation; retinal ganglion cell axon guidance; transmembrane receptor protein tyrosine phosphatase activity IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR013151; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Ptprm Kiaa4044 Mus musculus (Mouse) TR42675_c0_g1_i5 Q9Y2R2 PTN22_HUMAN 7.00E-52 GO:0017124; GO:0030217; GO:0050852; GO:0009898; GO:0019900; GO:0050868; GO:0050860; GO:0005634; GO:0048471; GO:0035644; GO:0004725; GO:0050855; GO:0045088; GO:0032817 P20963; P62993; P06239; P43403 SH3 domain binding; T cell differentiation; T cell receptor signaling pathway; internal side of plasma membrane; kinase binding; negative regulation of T cell activation; negative regulation of T cell receptor signaling pathway; nucleus; perinuclear region of cytoplasm; phosphoanandamide dephosphorylation; protein tyrosine phosphatase activity; regulation of B cell receptor signaling pathway; regulation of innate immune response; regulation of natural killer cell proliferation IPR016276; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP) PTPN22 PTPN8 Homo sapiens (Human) TR42675_c0_g2_i3 Q64487 PTPRD_MOUSE 7.00E-16 GO:0007157; GO:0016021; GO:0030182; GO:0035335; GO:0050775; GO:0097105; GO:0004725 P59823 heterophilic cell-cell adhesion; integral to membrane; neuron differentiation; peptidyl-tyrosine dephosphorylation; positive regulation of dendrite morphogenesis; presynaptic membrane assembly; protein tyrosine phosphatase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48) Ptprd Mus musculus (Mouse) TR42676_c0_g1_i1 A1AW09 SYI_RUTMC 2.00E-41 GO:0005524; GO:0002161; GO:0005737; GO:0004822; GO:0006428; GO:0006450; GO:0008270 ATP binding; aminoacyl-tRNA editing activity; cytoplasm; isoleucine-tRNA ligase activity; isoleucyl-tRNA aminoacylation; regulation of translational fidelity; zinc ion binding IPR001412; IPR002300; IPR002301; IPR023585; IPR014729; IPR009080; IPR013155; IPR009008; IPR010663; Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) ileS Rmag_0340 Ruthia magnifica subsp. Calyptogena magnifica TR42676_c0_g1_i2 Q5NQQ7 SYI_ZYMMO 2.00E-41 GO:0005524; GO:0002161; GO:0005737; GO:0004822; GO:0006428; GO:0006450; GO:0008270 ATP binding; aminoacyl-tRNA editing activity; cytoplasm; isoleucine-tRNA ligase activity; isoleucyl-tRNA aminoacylation; regulation of translational fidelity; zinc ion binding IPR001412; IPR002300; IPR002301; IPR023585; IPR014729; IPR009080; IPR013155; IPR009008; Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) ileS ZMO0323 Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) TR42676_c0_g2_i1 Q54YD4 SYIC_DICDI 0 GO:0005524; GO:0002161; GO:0005829; GO:0004822; GO:0006428; GO:0006450 ATP binding; aminoacyl-tRNA editing activity; cytosol; isoleucine-tRNA ligase activity; isoleucyl-tRNA aminoacylation; regulation of translational fidelity IPR001412; IPR002300; IPR002301; IPR023586; IPR014729; IPR009080; IPR013155; IPR009008; "Probable isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS)" ileS DDB_G0278293 Dictyostelium discoideum (Slime mold) TR42676_c0_g2_i2 P41252 SYIC_HUMAN 0 GO:0005524; GO:0002161; GO:0005829; GO:0004822; GO:0006428; GO:0005634; GO:0006450; GO:0006418 P07814 ATP binding; aminoacyl-tRNA editing activity; cytosol; isoleucine-tRNA ligase activity; isoleucyl-tRNA aminoacylation; nucleus; regulation of translational fidelity; tRNA aminoacylation for protein translation IPR001412; IPR002300; IPR002301; IPR023586; IPR014729; IPR009080; IPR013155; IPR009008; "Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS)" IARS Homo sapiens (Human) TR42676_c0_g2_i3 P41252 SYIC_HUMAN 0 GO:0005524; GO:0002161; GO:0005829; GO:0004822; GO:0006428; GO:0005634; GO:0006450; GO:0006418 P07814 ATP binding; aminoacyl-tRNA editing activity; cytosol; isoleucine-tRNA ligase activity; isoleucyl-tRNA aminoacylation; nucleus; regulation of translational fidelity; tRNA aminoacylation for protein translation IPR001412; IPR002300; IPR002301; IPR023586; IPR014729; IPR009080; IPR013155; IPR009008; "Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS)" IARS Homo sapiens (Human) TR42676_c0_g2_i4 Q17YZ0 SYL_HELAH 5.00E-10 GO:0005524; GO:0002161; GO:0005737; GO:0004823; GO:0006429; GO:0006450 ATP binding; aminoacyl-tRNA editing activity; cytoplasm; leucine-tRNA ligase activity; leucyl-tRNA aminoacylation; regulation of translational fidelity IPR001412; IPR002300; IPR002302; IPR025709; IPR015413; IPR014729; IPR009080; IPR009008; Leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) leuS Hac_0293 Helicobacter acinonychis (strain Sheeba) TR42677_c1_g1_i4 O88279 SLIT1_RAT 2.00E-11 GO:0048846; GO:0007420; GO:0005509; GO:0005737; GO:0033563; GO:0040023; GO:0005615; GO:0043395; GO:0008045; GO:0050919; GO:0048843; GO:0051964; GO:0031290; GO:0021510; GO:0022028 axon extension involved in axon guidance; brain development; calcium ion binding; cytoplasm; dorsal/ventral axon guidance; establishment of nucleus localization; extracellular space; heparan sulfate proteoglycan binding; motor neuron axon guidance; negative chemotaxis; negative regulation of axon extension involved in axon guidance; negative regulation of synapse assembly; retinal ganglion cell axon guidance; spinal cord development; tangential migration from the subventricular zone to the olfactory bulb IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4) Slit1 Megf4 Rattus norvegicus (Rat) TR42677_c1_g2_i1 Q9DD78 TLR21_CHICK 2.00E-20 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0005886; GO:0050729; GO:0050707; GO:0002237; GO:0035681; GO:0034134; GO:0034142; GO:0034146; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; plasma membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 15 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR018247; IPR001611; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 type-1 TLR2-1 Gallus gallus (Chicken) TR42677_c1_g2_i3 Q704V6 TLR6_BOVIN 1.00E-20 GO:0002755; GO:0042088; GO:0042496; GO:0006954; GO:0045087; GO:0016021; GO:0030670; GO:0005886; GO:0045410; GO:0050707; GO:0034150; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; T-helper 1 type immune response; detection of diacyl bacterial lipopeptide; inflammatory response; innate immune response; integral to membrane; phagocytic vesicle membrane; plasma membrane; positive regulation of interleukin-6 biosynthetic process; regulation of cytokine secretion; toll-like receptor 6 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR000157; IPR027187; IPR017241; Toll-like receptor 6 (CD antigen CD286) TLR6 Bos taurus (Bovine) TR42677_c1_g2_i4 Q2V898 TLR4_BOSTR 2.00E-15 GO:0002755; GO:0050829; GO:0032497; GO:0006954; GO:0045087; GO:0001875; GO:0046696; GO:0042116; GO:0050707; GO:0034142; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-negative bacterium; detection of lipopolysaccharide; inflammatory response; innate immune response; lipopolysaccharide receptor activity; lipopolysaccharide receptor complex; macrophage activation; regulation of cytokine secretion; toll-like receptor 4 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027168; IPR017241; Toll-like receptor 4 (CD antigen CD284) TLR4 Boselaphus tragocamelus (Nilgai) TR42677_c1_g2_i5 Q9TSP2 TLR4_PAPAN 2.00E-15 GO:0002755; GO:0050829; GO:0032497; GO:0006954; GO:0045087; GO:0001875; GO:0046696; GO:0042116; GO:0050707; GO:0034142; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-negative bacterium; detection of lipopolysaccharide; inflammatory response; innate immune response; lipopolysaccharide receptor activity; lipopolysaccharide receptor complex; macrophage activation; regulation of cytokine secretion; toll-like receptor 4 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR025875; IPR003591; IPR000157; IPR027168; IPR017241; Toll-like receptor 4 (CD antigen CD284) TLR4 Papio anubis (Olive baboon) TR42677_c1_g2_i6 Q9DD78 TLR21_CHICK 1.00E-21 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0005886; GO:0050729; GO:0050707; GO:0002237; GO:0035681; GO:0034134; GO:0034142; GO:0034146; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; plasma membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 15 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR018247; IPR001611; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 type-1 TLR2-1 Gallus gallus (Chicken) TR42678_c2_g1_i1 Q0Z7W6 TMX1_BOVIN 2.00E-56 GO:0045454; GO:0015036; GO:0005789; GO:0016021; GO:0043066 cell redox homeostasis; disulfide oxidoreductase activity; endoplasmic reticulum membrane; integral to membrane; negative regulation of apoptotic process IPR012336; IPR017937; IPR013766; Thioredoxin-related transmembrane protein 1 (Thioredoxin domain-containing protein 1) TMX1 TXNDC1 Bos taurus (Bovine) TR42678_c2_g4_i1 Q9H3N1 TMX1_HUMAN 2.00E-06 GO:0006260; GO:0006888; GO:0030612; GO:0008283; GO:0045454; GO:0015036; GO:0005789; GO:0016021; GO:0045321; GO:0043066; GO:0045927; GO:0045893; GO:0006950; GO:0007165 "DNA replication; ER to Golgi vesicle-mediated transport; arsenate reductase (thioredoxin) activity; cell proliferation; cell redox homeostasis; disulfide oxidoreductase activity; endoplasmic reticulum membrane; integral to membrane; leukocyte activation; negative regulation of apoptotic process; positive regulation of growth; positive regulation of transcription, DNA-dependent; response to stress; signal transduction" IPR012336; IPR017937; IPR013766; Thioredoxin-related transmembrane protein 1 (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein) TMX1 TMX TXNDC TXNDC1 PSEC0085 UNQ235/PRO268 Homo sapiens (Human) TR42679_c2_g2_i1 Q54HH2 SRR_DICDI 1.00E-68 GO:0005524; GO:0008721; GO:0070179; GO:0003941; GO:0006563; GO:0005737; GO:0000287; GO:0018249; GO:0030170; GO:0030378 ATP binding; D-serine ammonia-lyase activity; D-serine biosynthetic process; L-serine ammonia-lyase activity; L-serine metabolic process; cytoplasm; magnesium ion binding; protein dehydration; pyridoxal phosphate binding; serine racemase activity IPR001926; Probable serine racemase (EC 4.3.1.17) (EC 4.3.1.18) (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (L-serine ammonia-lyase) (L-serine dehydratase) srr DDB_G0289463 Dictyostelium discoideum (Slime mold) TR42680_c0_g4_i1 Q08509 EPS8_MOUSE 3.00E-52 GO:0017146; GO:0048365; GO:0016601; GO:0003779; GO:0051764; GO:0031532; GO:0051017; GO:0070358; GO:0008344; GO:0051016; GO:0048149; GO:0005938; GO:0036336; GO:0010458; GO:0030426; GO:0014069; GO:0008360; GO:0032587; GO:0032420 Q8IZP0; Q8CBW3; Q9UQB8; O43813 N-methyl-D-aspartate selective glutamate receptor complex; Rac GTPase binding; Rac protein signal transduction; actin binding; actin crosslink formation; actin cytoskeleton reorganization; actin filament bundle assembly; actin polymerization-dependent cell motility; adult locomotory behavior; barbed-end actin filament capping; behavioral response to ethanol; cell cortex; dendritic cell migration; exit from mitosis; growth cone; postsynaptic density; regulation of cell shape; ruffle membrane; stereocilium IPR011993; IPR013625; IPR006020; IPR001452; Epidermal growth factor receptor kinase substrate 8 Eps8 Mus musculus (Mouse) TR42680_c0_g4_i3 Q9H6S3 ES8L2_HUMAN 4.00E-44 GO:0005737; GO:0005886 cytoplasm; plasma membrane IPR011993; IPR013625; IPR006020; IPR001452; Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) EPS8L2 EPS8R2 PP13181 Homo sapiens (Human) TR42680_c0_g4_i6 Q08509 EPS8_MOUSE 4.00E-63 GO:0017146; GO:0048365; GO:0016601; GO:0003779; GO:0051764; GO:0031532; GO:0051017; GO:0070358; GO:0008344; GO:0051016; GO:0048149; GO:0005938; GO:0036336; GO:0010458; GO:0030426; GO:0014069; GO:0008360; GO:0032587; GO:0032420 Q8IZP0; Q8CBW3; Q9UQB8; O43813 N-methyl-D-aspartate selective glutamate receptor complex; Rac GTPase binding; Rac protein signal transduction; actin binding; actin crosslink formation; actin cytoskeleton reorganization; actin filament bundle assembly; actin polymerization-dependent cell motility; adult locomotory behavior; barbed-end actin filament capping; behavioral response to ethanol; cell cortex; dendritic cell migration; exit from mitosis; growth cone; postsynaptic density; regulation of cell shape; ruffle membrane; stereocilium IPR011993; IPR013625; IPR006020; IPR001452; Epidermal growth factor receptor kinase substrate 8 Eps8 Mus musculus (Mouse) TR42681_c3_g1_i1 Q9P0U1 TOM7_HUMAN 6.00E-12 GO:0044267; GO:0016021; GO:0005742; GO:0030150; GO:0006626; GO:0008320 Q9NS69 cellular protein metabolic process; integral to membrane; mitochondrial outer membrane translocase complex; protein import into mitochondrial matrix; protein targeting to mitochondrion; protein transmembrane transporter activity IPR012621; Mitochondrial import receptor subunit TOM7 homolog (Translocase of outer membrane 7 kDa subunit homolog) TOMM7 TOM7 TOMM07 AD-014 Homo sapiens (Human) TR42681_c5_g2_i1 Q5BIS9 AAKB1_BOVIN 7.00E-80 GO:0006633; GO:0005634; GO:0010628; GO:0004672 fatty acid biosynthetic process; nucleus; positive regulation of gene expression; protein kinase activity IPR006828; IPR014756; 5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) PRKAB1 Bos taurus (Bovine) TR42682_c1_g1_i3 Q28709 CD63_RABIT 5.00E-11 GO:0016021; GO:0031902; GO:0005765; GO:0005886 integral to membrane; late endosome membrane; lysosomal membrane; plasma membrane IPR000301; IPR018499; IPR018503; IPR008952; CD63 antigen (CD antigen CD63) CD63 Oryctolagus cuniculus (Rabbit) TR42682_c1_g1_i8 Q28709 CD63_RABIT 8.00E-11 GO:0016021; GO:0031902; GO:0005765; GO:0005886 integral to membrane; late endosome membrane; lysosomal membrane; plasma membrane IPR000301; IPR018499; IPR018503; IPR008952; CD63 antigen (CD antigen CD63) CD63 Oryctolagus cuniculus (Rabbit) TR42683_c1_g1_i4 P25782 CYSP2_HOMAM 9.00E-07 GO:0008234; GO:0006508 cysteine-type peptidase activity; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Digestive cysteine proteinase 2 (EC 3.4.22.-) LCP2 Homarus americanus (American lobster) TR42683_c1_g2_i1 P53634 CATC_HUMAN 8.00E-83 GO:0005794; GO:0001913; GO:0007568; GO:0031404; GO:0008234; GO:0005783; GO:0006955; GO:0005764; GO:0006508; GO:0010033; GO:0004252 O76096 Golgi apparatus; T cell mediated cytotoxicity; aging; chloride ion binding; cysteine-type peptidase activity; endoplasmic reticulum; immune response; lysosome; proteolysis; response to organic substance; serine-type endopeptidase activity IPR014882; IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] CTSC CPPI Homo sapiens (Human) TR42683_c1_g2_i2 Q5RB02 CATC_PONAB 3.00E-178 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR014882; IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] CTSC Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42683_c1_g2_i3 Q9GKL8 CATL1_CHLAE 5.00E-29 GO:0008234; GO:0005764; GO:0006508 cysteine-type peptidase activity; lysosome; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L1 (EC 3.4.22.15) (Cathepsin L) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain] CTSL CTSL1 Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) TR42687_c3_g2_i1 P21613 KINH_LOLPE 0 GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0007018 ATP binding; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement IPR027640; IPR019821; IPR001752; IPR027417; Kinesin heavy chain Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR42687_c3_g2_i2 P34540 KINH_CAEEL 0 GO:0005524; GO:0005737; GO:0009792; GO:0051296; GO:0016938; GO:0040011; GO:0005874; GO:0007018; GO:0005635; GO:0008574; GO:0040038; GO:0010940; GO:0048489 ATP binding; cytoplasm; embryo development ending in birth or egg hatching; establishment of meiotic spindle orientation; kinesin I complex; locomotion; microtubule; microtubule-based movement; nuclear envelope; plus-end-directed microtubule motor activity; polar body extrusion after meiotic divisions; positive regulation of necrotic cell death; synaptic vesicle transport IPR027640; IPR019821; IPR001752; IPR027417; Kinesin heavy chain (Uncoordinated protein 116) (Protein unc-116) unc-116 khc-1 R05D3.7 Caenorhabditis elegans TR42687_c3_g2_i4 P21613 KINH_LOLPE 0 GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0007018 ATP binding; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement IPR027640; IPR019821; IPR001752; IPR027417; Kinesin heavy chain Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR42690_c1_g1_i1 P20369 ADH1_KLULA 4.00E-15 GO:0004022; GO:0005737; GO:0008270 alcohol dehydrogenase (NAD) activity; cytoplasm; zinc ion binding IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; Alcohol dehydrogenase 1 (EC 1.1.1.1) (Alcohol dehydrogenase I) ADH1 KLLA0F21010g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR42690_c1_g1_i10 Q6AYT0 QOR_RAT 2.00E-127 GO:0070402; GO:0003960; GO:0005829; GO:0003730; GO:0051289; GO:0042178; GO:0008270 NADPH binding; NADPH:quinone reductase activity; cytosol; mRNA 3'-UTR binding; protein homotetramerization; xenobiotic catabolic process; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; IPR002364; Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin) Cryz Rattus norvegicus (Rat) TR42690_c1_g1_i11 O74489 QOR_SCHPO 1.00E-27 GO:0003960; GO:0005829; GO:0035925; GO:0016071; GO:0005634; GO:0008270 NADPH:quinone reductase activity; cytosol; mRNA 3'-UTR AU-rich region binding; mRNA metabolic process; nucleus; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; Probable quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) zta1 SPCC1442.16c SPCC285.01c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42690_c1_g1_i13 P00331 ADH2_YEAST 9.00E-07 GO:0006116; GO:0004022; GO:0000947; GO:0005737; GO:0006067; GO:0008270 NADH oxidation; alcohol dehydrogenase (NAD) activity; amino acid catabolic process to alcohol via Ehrlich pathway; cytoplasm; ethanol metabolic process; zinc ion binding IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; Alcohol dehydrogenase 2 (EC 1.1.1.1) (Alcohol dehydrogenase II) (YADH-2) ADH2 ADR2 YMR303C YM9952.05C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42690_c1_g1_i2 Q9ZUC1 QORL_ARATH 4.00E-26 GO:0035798; GO:0048046; GO:0009941; GO:0009570; GO:0035671; GO:0009409; GO:0010319; GO:0009579; GO:0008270 2-alkenal reductase (NADP+) activity; apoplast; chloroplast envelope; chloroplast stroma; enone reductase activity; response to cold; stromule; thylakoid; zinc ion binding IPR013154; IPR002085; IPR011032; IPR016040; IPR002364; "Quinone oxidoreductase-like protein At1g23740, chloroplastic (EC 1.-.-.-)" At1g23740 F5O8.29 Arabidopsis thaliana (Mouse-ear cress) TR42690_c1_g1_i3 O97764 QOR_BOVIN 2.00E-124 GO:0003677; GO:0050661; GO:0070402; GO:0003960; GO:0005829; GO:0003730; GO:0051289; GO:0042178; GO:0008270 DNA binding; NADP binding; NADPH binding; NADPH:quinone reductase activity; cytosol; mRNA 3'-UTR binding; protein homotetramerization; xenobiotic catabolic process; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; IPR002364; Zeta-crystallin CRYZ Bos taurus (Bovine) TR42690_c1_g1_i4 Q06099 FADH_CANMA 7.00E-09 GO:0051903; GO:0006069; GO:0008270 S-(hydroxymethyl)glutathione dehydrogenase activity; ethanol oxidation; zinc ion binding IPR014183; IPR013149; IPR013154; IPR002085; IPR002328; IPR011032; IPR016040; S-(hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (FLD) (GSH-FDH) (EC 1.1.1.-) FDH1 ADH1 Candida maltosa (Yeast) TR42690_c1_g1_i5 Q6GQN8 MECR_DANRE 1.00E-14 GO:0006633; GO:0005739; GO:0039020; GO:0019166; GO:0008270 fatty acid biosynthetic process; mitochondrion; pronephric nephron tubule development; trans-2-enoyl-CoA reductase (NADPH) activity; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; "Trans-2-enoyl-CoA reductase, mitochondrial (EC 1.3.1.38)" mecr zgc:110153 Danio rerio (Zebrafish) (Brachydanio rerio) TR42690_c1_g1_i6 P11415 QOR_CAVPO 5.00E-124 GO:0070402; GO:0003960; GO:0005829; GO:0003730; GO:0051289; GO:0005212; GO:0042178; GO:0008270 NADPH binding; NADPH:quinone reductase activity; cytosol; mRNA 3'-UTR binding; protein homotetramerization; structural constituent of eye lens; xenobiotic catabolic process; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; IPR002364; Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin) CRYZ Cavia porcellus (Guinea pig) TR42690_c1_g1_i8 Q6AYT0 QOR_RAT 7.00E-127 GO:0070402; GO:0003960; GO:0005829; GO:0003730; GO:0051289; GO:0042178; GO:0008270 NADPH binding; NADPH:quinone reductase activity; cytosol; mRNA 3'-UTR binding; protein homotetramerization; xenobiotic catabolic process; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; IPR002364; Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin) Cryz Rattus norvegicus (Rat) TR42690_c1_g1_i9 Q08257 QOR_HUMAN 4.00E-126 GO:0005794; GO:0070402; GO:0003960; GO:0005829; GO:0003730; GO:0051289; GO:0007601; GO:0042178; GO:0008270 Golgi apparatus; NADPH binding; NADPH:quinone reductase activity; cytosol; mRNA 3'-UTR binding; protein homotetramerization; visual perception; xenobiotic catabolic process; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; IPR002364; Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin) CRYZ Homo sapiens (Human) TR42692_c0_g2_i1 A7E305 K0913_BOVIN 4.00E-34 GO:0008270 zinc ion binding IPR007527; Zinc finger SWIM domain-containing protein 8 ZSWIM8 Bos taurus (Bovine) TR42694_c2_g1_i1 Q9DCU2 PLLP_MOUSE 7.00E-07 GO:0043218; GO:0016021; GO:0006811; GO:0045121; GO:0042552; GO:0009611 compact myelin; integral to membrane; ion transport; membrane raft; myelination; response to wounding IPR013295; IPR008253; Plasmolipin (Plasma membrane proteolipid) Pllp Plapi Pmlp Tm4sf11 Mus musculus (Mouse) TR42694_c2_g1_i3 Q8CJ61 CKLF4_MOUSE 4.00E-06 GO:0006935; GO:0005615; GO:0016021 chemotaxis; extracellular space; integral to membrane IPR008253; CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine-like factor superfamily member 4) Cmtm4 Cklfsf4 Mus musculus (Mouse) TR42695_c0_g1_i1 O75691 UTP20_HUMAN 0 GO:0030686; GO:0005737; GO:0000480; GO:0000447; GO:0000472; GO:0008285; GO:0005730; GO:0005654; GO:0030688; GO:0032040 Q5T8A7 "90S preribosome; cytoplasm; endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); negative regulation of cell proliferation; nucleolus; nucleoplasm; preribosome, small subunit precursor; small-subunit processome" IPR011989; IPR016024; IPR011430; Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) UTP20 DRIM Homo sapiens (Human) TR42699_c3_g2_i1 Q3KR53 GPBL1_RAT 5.00E-11 GO:0003677; GO:0005634; GO:0045893; GO:0003700; GO:0006351 "DNA binding; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR028128; Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) Gpbp1l1 Rattus norvegicus (Rat) TR42700_c2_g1_i1 Q24629 REF2P_DROSI 4.00E-07 GO:0003677; GO:0005634; GO:0008270 DNA binding; nucleus; zinc ion binding IPR000270; IPR009060; IPR015940; IPR000433; Protein ref(2)P (Refractory to sigma P) ref(2)P Drosophila simulans (Fruit fly) TR42700_c2_g5_i1 Q5BL31 CF106_DANRE 4.00E-11 IPR009060; Uncharacterized protein C6orf106 homolog zgc:101577 Danio rerio (Zebrafish) (Brachydanio rerio) TR42700_c2_g5_i2 Q14596 NBR1_HUMAN 6.00E-25 GO:0031430; GO:0005776; GO:0031410; GO:0005829; GO:0005770; GO:0005764; GO:0016236; GO:0051019; GO:0045668; GO:0000407; GO:0051259; GO:0030500; GO:0032872; GO:0043130; GO:0008270 P38182; O95166; Q9H0R8; P60520; P42858; Q9H492; Q9GZQ8; Q9BXW4; Q13501; P40818 M band; autophagic vacuole; cytoplasmic vesicle; cytosol; late endosome; lysosome; macroautophagy; mitogen-activated protein kinase binding; negative regulation of osteoblast differentiation; pre-autophagosomal structure; protein oligomerization; regulation of bone mineralization; regulation of stress-activated MAPK cascade; ubiquitin binding; zinc ion binding IPR000270; IPR009060; IPR015940; IPR000433; Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) NBR1 1A13B KIAA0049 M17S2 MIG19 Homo sapiens (Human) TR42701_c0_g1_i1 Q8IN94 OSA_DROME 5.00E-93 GO:0003677; GO:0016055; GO:0035060; GO:0016568; GO:0007480; GO:0008587; GO:0008586; GO:0046530; GO:0045893; GO:0042058; GO:0007379; GO:0006351; GO:0048190 P25439 "DNA binding; Wnt receptor signaling pathway; brahma complex; chromatin modification; imaginal disc-derived leg morphogenesis; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein morphogenesis; photoreceptor cell differentiation; positive regulation of transcription, DNA-dependent; regulation of epidermal growth factor receptor signaling pathway; segment specification; transcription, DNA-dependent; wing disc dorsal/ventral pattern formation" IPR001606; IPR016024; IPR021906; Trithorax group protein osa (Protein eyelid) osa eld CG7467 Drosophila melanogaster (Fruit fly) TR42701_c0_g1_i2 Q9Z1N7 ARI3B_MOUSE 3.00E-15 GO:0003677; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001606; IPR023334; AT-rich interactive domain-containing protein 3B (ARID domain-containing protein 3B) (Bright and dead ringer protein) (Bright-like protein) Arid3b Bdp Dril2 Mus musculus (Mouse) TR42701_c0_g1_i3 Q8IN94 OSA_DROME 2.00E-32 GO:0003677; GO:0016055; GO:0035060; GO:0016568; GO:0007480; GO:0008587; GO:0008586; GO:0046530; GO:0045893; GO:0042058; GO:0007379; GO:0006351; GO:0048190 P25439 "DNA binding; Wnt receptor signaling pathway; brahma complex; chromatin modification; imaginal disc-derived leg morphogenesis; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein morphogenesis; photoreceptor cell differentiation; positive regulation of transcription, DNA-dependent; regulation of epidermal growth factor receptor signaling pathway; segment specification; transcription, DNA-dependent; wing disc dorsal/ventral pattern formation" IPR001606; IPR016024; IPR021906; Trithorax group protein osa (Protein eyelid) osa eld CG7467 Drosophila melanogaster (Fruit fly) TR42702_c0_g2_i1 Q52T38 ZDH22_ARATH 7.00E-19 GO:0005794; GO:0000139; GO:0016417; GO:0000035; GO:0009932; GO:0030659; GO:0005768; GO:0016021; GO:0005802; GO:0008270 Golgi apparatus; Golgi membrane; S-acyltransferase activity; acyl binding; cell tip growth; cytoplasmic vesicle membrane; endosome; integral to membrane; trans-Golgi network; zinc ion binding IPR002110; IPR020683; IPR001594; Protein S-acyltransferase 24 (EC 2.3.1.225) (Ankyrin repeat-containing S-palmitoyltransferase) (Palmitoyltransferase TIP1) (Protein TIP GROWTH DEFECTIVE 1) (AtTIP1) (Zinc finger DHHC domain-containing protein TIP1) PAT24 TIP1 At5g20350 F5O24.240 Arabidopsis thaliana (Mouse-ear cress) TR42702_c0_g2_i2 A2A690 TANC2_MOUSE 3.00E-19 GO:0001701 in utero embryonic development IPR002110; IPR020683; IPR027417; IPR013026; IPR011990; IPR019734; "Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2)" Tanc2 Kiaa1148 Mus musculus (Mouse) TR42702_c0_g2_i4 Q9Y283 INVS_HUMAN 0 GO:0016055; GO:0005929; GO:0005737; GO:0060971; GO:0001822; GO:0016020; GO:0005874; GO:0090090; GO:0005634; GO:0031016; GO:0009791; GO:0005819 Q9BPU9 Wnt receptor signaling pathway; cilium; cytoplasm; embryonic heart tube left/right pattern formation; kidney development; membrane; microtubule; negative regulation of canonical Wnt receptor signaling pathway; nucleus; pancreas development; post-embryonic development; spindle IPR002110; IPR020683; IPR000048; Inversin (Inversion of embryo turning homolog) (Nephrocystin-2) INVS INV NPHP2 Homo sapiens (Human) TR42702_c0_g2_i5 Q8UVC3 INVS_CHICK 0 GO:0016055; GO:0005737; GO:0005856; GO:0007275 Wnt receptor signaling pathway; cytoplasm; cytoskeleton; multicellular organismal development IPR002110; IPR020683; IPR000048; Inversin INVS Gallus gallus (Chicken) TR42702_c0_g2_i6 Q9ULH0 KDIS_HUMAN 4.00E-30 GO:0030165; GO:0000186; GO:0016482; GO:0005829; GO:0048813; GO:0001701; GO:0016021; GO:0005770; GO:0038180; GO:0048011; GO:0010976; GO:0043234 PDZ domain binding; activation of MAPKK activity; cytoplasmic transport; cytosol; dendrite morphogenesis; in utero embryonic development; integral to membrane; late endosome; nerve growth factor signaling pathway; neurotrophin TRK receptor signaling pathway; positive regulation of neuron projection development; protein complex IPR002110; IPR020683; IPR011646; IPR013761; Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) KIDINS220 ARMS KIAA1250 Homo sapiens (Human) TR42702_c0_g2_i7 Q9ZCL3 Y714_RICPR 6.00E-06 IPR002110; IPR020683; Putative ankyrin repeat protein RP714 RP714 Rickettsia prowazekii (strain Madrid E) TR42702_c0_g2_i8 Q9HFE7 YNW5_SCHPO 7.00E-13 GO:0005829; GO:0005634; GO:0030688; GO:0042254 "cytosol; nucleus; preribosome, small subunit precursor; ribosome biogenesis" IPR002110; IPR020683; Ankyrin repeat-containing protein P16F5.05c SPBP16F5.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42704_c0_g1_i1 Q27128 PAPSS_URECA 0 GO:0005524; GO:0004020; GO:0004781; GO:0000103 ATP binding; adenylylsulfate kinase activity; sulfate adenylyltransferase (ATP) activity; sulfate assimilation IPR002891; IPR025980; IPR027417; IPR015947; IPR014729; IPR024951; IPR002650; Sulfur metabolism; sulfate assimilation. Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase (PAPS synthase) (PAPSS) (Sulfurylase kinase) (SK) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] Urechis caupo (Innkeeper worm) (Spoonworm) TR42704_c0_g1_i2 Q0CC19 MET3_ASPTN 3.00E-28 GO:0005524; GO:0004020; GO:0019344; GO:0005737; GO:0070814; GO:0009086; GO:0004781; GO:0000103 ATP binding; adenylylsulfate kinase activity; cysteine biosynthetic process; cytoplasm; hydrogen sulfide biosynthetic process; methionine biosynthetic process; sulfate adenylyltransferase (ATP) activity; sulfate assimilation IPR002891; IPR025980; IPR027417; IPR015947; IPR014729; IPR027535; IPR024951; IPR002650; Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3. Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT) met3 sCT ATEG_08765 Aspergillus terreus (strain NIH 2624 / FGSC A1156) TR42704_c0_g1_i3 Q9P7G9 KAPS_SCHPO 3.00E-67 GO:0005524; GO:0004020; GO:0019344; GO:0005829; GO:0070814; GO:0009086; GO:0005634; GO:0000103 ATP binding; adenylylsulfate kinase activity; cysteine biosynthetic process; cytosol; hydrogen sulfide biosynthetic process; methionine biosynthetic process; nucleus; sulfate assimilation IPR002891; IPR027417; Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3. Adenylyl-sulfate kinase (EC 2.7.1.25) (ATP adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenosine-5'-phosphosulfate kinase) (APS kinase) met14 SPAC1782.11 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42704_c0_g1_i4 Q27128 PAPSS_URECA 0 GO:0005524; GO:0004020; GO:0004781; GO:0000103 ATP binding; adenylylsulfate kinase activity; sulfate adenylyltransferase (ATP) activity; sulfate assimilation IPR002891; IPR025980; IPR027417; IPR015947; IPR014729; IPR024951; IPR002650; Sulfur metabolism; sulfate assimilation. Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase (PAPS synthase) (PAPSS) (Sulfurylase kinase) (SK) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] Urechis caupo (Innkeeper worm) (Spoonworm) TR42704_c0_g1_i5 Q9P7G9 KAPS_SCHPO 7.00E-70 GO:0005524; GO:0004020; GO:0019344; GO:0005829; GO:0070814; GO:0009086; GO:0005634; GO:0000103 ATP binding; adenylylsulfate kinase activity; cysteine biosynthetic process; cytosol; hydrogen sulfide biosynthetic process; methionine biosynthetic process; nucleus; sulfate assimilation IPR002891; IPR027417; Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3. Adenylyl-sulfate kinase (EC 2.7.1.25) (ATP adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenosine-5'-phosphosulfate kinase) (APS kinase) met14 SPAC1782.11 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42705_c0_g1_i1 Q9JHU4 DYHC1_MOUSE 0 GO:0005524; GO:0006200; GO:0016887; GO:0005794; GO:0005858; GO:0005813; GO:0003341; GO:0005737; GO:0033962; GO:0070062; GO:0030175; GO:0005874; GO:0003777; GO:0034063; GO:0006810 P07141 ATP binding; ATP catabolic process; ATPase activity; Golgi apparatus; axonemal dynein complex; centrosome; cilium movement; cytoplasm; cytoplasmic mRNA processing body assembly; extracellular vesicular exosome; filopodium; microtubule; microtubule motor activity; stress granule assembly; transport IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)" Dync1h1 Dhc1 Dnch1 Dnchc1 Dyhc Mus musculus (Mouse) TR42705_c0_g2_i2 P37276 DYHC_DROME 0 GO:0005524; GO:0042623; GO:0005794; GO:0050658; GO:0008088; GO:0005938; GO:0007098; GO:0051642; GO:0040003; GO:0007282; GO:0005868; GO:0048813; GO:0051683; GO:0045198; GO:0040001; GO:0007301; GO:0045169; GO:0048134; GO:0007294; GO:0045172; GO:0008298; GO:0006886; GO:0000776; GO:0051237; GO:0035011; GO:0005874; GO:0003777; GO:0048311; GO:0047497; GO:0007067; GO:0007052; GO:0043148; GO:0016319; GO:0007405; GO:0007312; GO:0030723; GO:0007279; GO:0046604; GO:2001019; GO:0034501; GO:0030071; GO:0030529; GO:0034063 "ATP binding; ATPase activity, coupled; Golgi apparatus; RNA transport; axon cargo transport; cell cortex; centrosome cycle; centrosome localization; chitin-based cuticle development; cystoblast division; cytoplasmic dynein complex; dendrite morphogenesis; establishment of Golgi localization; establishment of epithelial cell apical/basal polarity; establishment of mitotic spindle localization; female germline ring canal formation; fusome; germ-line cyst formation; germarium-derived oocyte fate determination; germline ring canal; intracellular mRNA localization; intracellular protein transport; kinetochore; maintenance of RNA location; melanotic encapsulation of foreign target; microtubule; microtubule motor activity; mitochondrion distribution; mitochondrion transport along microtubule; mitosis; mitotic spindle organization; mitotic spindle stabilization; mushroom body development; neuroblast proliferation; oocyte nucleus migration involved in oocyte dorsal/ventral axis specification; ovarian fusome organization; pole cell formation; positive regulation of mitotic centrosome separation; positive regulation of retrograde axon cargo transport; protein localization to kinetochore; regulation of mitotic metaphase/anaphase transition; ribonucleoprotein complex; stress granule assembly" IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain, cytoplasmic (Dynein heavy chain, cytosolic) (DYHC)" Dhc64C cDhc CG7507 Drosophila melanogaster (Fruit fly) TR42706_c1_g1_i11 Q20930 MIG17_CAEEL 7.00E-26 GO:0005604; GO:0005615; GO:0035262; GO:0046872; GO:0004222; GO:0006508; GO:0030334 basement membrane; extracellular space; gonad morphogenesis; metal ion binding; metalloendopeptidase activity; proteolysis; regulation of cell migration IPR024079; IPR001590; IPR010909; ADAM family mig-17 (EC 3.4.24.-) (A disintegrin and metalloproteinase mig-17) (Abnormal cell migration protein 17) mig-17 F57B7.4 Caenorhabditis elegans TR42706_c1_g1_i5 Q69Z28 ATS16_MOUSE 3.00E-23 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16) (EC 3.4.24.-) Adamts16 Kiaa2029 Mus musculus (Mouse) TR42706_c1_g1_i6 Q20930 MIG17_CAEEL 6.00E-26 GO:0005604; GO:0005615; GO:0035262; GO:0046872; GO:0004222; GO:0006508; GO:0030334 basement membrane; extracellular space; gonad morphogenesis; metal ion binding; metalloendopeptidase activity; proteolysis; regulation of cell migration IPR024079; IPR001590; IPR010909; ADAM family mig-17 (EC 3.4.24.-) (A disintegrin and metalloproteinase mig-17) (Abnormal cell migration protein 17) mig-17 F57B7.4 Caenorhabditis elegans TR42707_c1_g1_i3 Q4J9S8 PCKG_SULAC 1.00E-18 GO:0005525; GO:0005737; GO:0006094; GO:0030145; GO:0004613 GTP binding; cytoplasm; gluconeogenesis; manganese ion binding; phosphoenolpyruvate carboxykinase (GTP) activity IPR013035; IPR008209; IPR008210; Carbohydrate biosynthesis; gluconeogenesis. Phosphoenolpyruvate carboxykinase [GTP] (PEP carboxykinase) (PEPCK) (EC 4.1.1.32) (Phosphoenolpyruvate carboxylase) pckG Saci_1100 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) TR42707_c1_g1_i5 P29190 PCKG_HAECO 6.00E-121 GO:0005525; GO:0006094; GO:0046872; GO:0004613 GTP binding; gluconeogenesis; metal ion binding; phosphoenolpyruvate carboxykinase (GTP) activity IPR018091; IPR013035; IPR008209; IPR008210; Phosphoenolpyruvate carboxykinase [GTP] (PEPCK) (EC 4.1.1.32) (Phosphoenolpyruvate carboxylase) PEPCK Haemonchus contortus (Barber pole worm) TR42707_c1_g3_i1 Q16822 PCKGM_HUMAN 7.00E-148 GO:0005525; GO:0006094; GO:0046872; GO:0005759; GO:0004613; GO:0004611; GO:0044281 P84022 GTP binding; gluconeogenesis; metal ion binding; mitochondrial matrix; phosphoenolpyruvate carboxykinase (GTP) activity; phosphoenolpyruvate carboxykinase activity; small molecule metabolic process IPR018091; IPR013035; IPR008209; IPR008210; Carbohydrate biosynthesis; gluconeogenesis. "Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32) (Phosphoenolpyruvate carboxylase)" PCK2 PEPCK2 Homo sapiens (Human) TR42707_c1_g3_i2 Q9PLL6 PCKG_CHLMU 5.00E-99 GO:0005525; GO:0005737; GO:0006094; GO:0030145; GO:0004613 GTP binding; cytoplasm; gluconeogenesis; manganese ion binding; phosphoenolpyruvate carboxykinase (GTP) activity IPR018091; IPR013035; IPR008209; IPR008210; Carbohydrate biosynthesis; gluconeogenesis. Phosphoenolpyruvate carboxykinase [GTP] (PEP carboxykinase) (PEPCK) (EC 4.1.1.32) (Phosphoenolpyruvate carboxylase) pckG TC_0083 Chlamydia muridarum (strain MoPn / Nigg) TR42708_c0_g1_i1 Q14697 GANAB_HUMAN 0 GO:0005794; GO:0030246; GO:0005788; GO:0033919; GO:0017177; GO:0042470; GO:0043687; GO:0018279; GO:0006457 P78545; P48634; Q9Y4K3 "Golgi apparatus; carbohydrate binding; endoplasmic reticulum lumen; glucan 1,3-alpha-glucosidase activity; glucosidase II complex; melanosome; post-translational protein modification; protein N-linked glycosylation via asparagine; protein folding" IPR011013; IPR000322; IPR025887; IPR017853; Glycan metabolism; N-glycan metabolism. Neutral alpha-glucosidase AB (EC 3.2.1.84) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) GANAB G2AN KIAA0088 Homo sapiens (Human) TR42708_c0_g1_i3 P79403 GANAB_PIG 3.00E-162 GO:0005794; GO:0030246; GO:0005975; GO:0005783; GO:0033919; GO:0042470 "Golgi apparatus; carbohydrate binding; carbohydrate metabolic process; endoplasmic reticulum; glucan 1,3-alpha-glucosidase activity; melanosome" IPR011013; IPR000322; IPR025887; IPR017853; Glycan metabolism; N-glycan metabolism. Neutral alpha-glucosidase AB (EC 3.2.1.84) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) GANAB Sus scrofa (Pig) TR42709_c1_g1_i1 O57422 OPN4B_XENLA 5.00E-06 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR027430; Melanopsin-B (Opsin-4B) (xMOP) opn4b mop Xenopus laevis (African clawed frog) TR42709_c1_g1_i2 O57422 OPN4B_XENLA 5.00E-06 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR027430; Melanopsin-B (Opsin-4B) (xMOP) opn4b mop Xenopus laevis (African clawed frog) TR42710_c0_g2_i1 Q495B1 AKD1A_HUMAN 5.00E-16 GO:0007165 signal transduction IPR002110; IPR020683; IPR011029; IPR000488; Ankyrin repeat and death domain-containing protein 1A ANKDD1A Homo sapiens (Human) TR42710_c0_g2_i2 P23631 LATA_LATTR 3.00E-23 GO:0006887; GO:0016021; GO:0072556 exocytosis; integral to membrane; other organism presynaptic membrane IPR002110; IPR020683; IPR028047; Alpha-latrotoxin-Lt1a (Alpha-LTX-Lt1a) (Alpha-latrotoxin) (Alpha-LTX) Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus) TR42710_c0_g3_i1 Q9P2R3 ANFY1_HUMAN 0 GO:0010008; GO:0005765; GO:0046872 P60520 endosome membrane; lysosomal membrane; metal ion binding IPR002110; IPR020683; IPR000210; IPR011333; IPR013069; IPR000306; IPR017455; IPR011011; IPR013083; Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif) ANKFY1 ANKHZN KIAA1255 Homo sapiens (Human) TR42710_c0_g3_i2 B9DHT4 ARIA_ARATH 4.00E-09 GO:0010187; GO:0005634; GO:0005886; GO:0016567; GO:0009737; GO:0009651 negative regulation of seed germination; nucleus; plasma membrane; protein ubiquitination; response to abscisic acid stimulus; response to salt stress IPR011989; IPR016024; IPR000225; IPR000210; IPR011333; IPR013069; Protein modification; protein ubiquitination. ARM REPEAT PROTEIN INTERACTING WITH ABF2 (ARIA) ARIA At5g19330 F7K24.80 Arabidopsis thaliana (Mouse-ear cress) TR42711_c1_g3_i1 Q8N695 SC5A8_HUMAN 3.00E-89 GO:0016324; GO:0006915; GO:0016021; GO:0006811; GO:0005886; GO:0006814; GO:0015293; GO:0055085 apical plasma membrane; apoptotic process; integral to membrane; ion transport; plasma membrane; sodium ion transport; symporter activity; transmembrane transport IPR001734; IPR019900; Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8) SLC5A8 AIT SMCT SMCT1 Homo sapiens (Human) TR42711_c1_g3_i2 Q28728 SC5AB_RABIT 3.00E-12 GO:0006915; GO:0008643; GO:0016021; GO:0006814; GO:0015293 apoptotic process; carbohydrate transport; integral to membrane; sodium ion transport; symporter activity IPR001734; IPR019900; Sodium/myo-inositol cotransporter 2 (Na(+)/myo-inositol cotransporter 2) (Sodium-dependent glucose cotransporter) (Sodium/glucose cotransporter KST1) (rKST1) (Sodium/myo-inositol transporter 2) (SMIT2) (Solute carrier family 5 member 11) SLC5A11 KST1 SMIT2 Oryctolagus cuniculus (Rabbit) TR42711_c1_g3_i4 Q8N695 SC5A8_HUMAN 7.00E-89 GO:0016324; GO:0006915; GO:0016021; GO:0006811; GO:0005886; GO:0006814; GO:0015293; GO:0055085 apical plasma membrane; apoptotic process; integral to membrane; ion transport; plasma membrane; sodium ion transport; symporter activity; transmembrane transport IPR001734; IPR019900; Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8) SLC5A8 AIT SMCT SMCT1 Homo sapiens (Human) TR42712_c0_g2_i1 Q6PAM1 TXLNA_MOUSE 3.00E-92 GO:0042113; GO:0005737; GO:0006887 B cell activation; cytoplasm; exocytosis IPR026183; Alpha-taxilin Txlna Txln Mus musculus (Mouse) TR42714_c0_g1_i1 Q7Z6Z7 HUWE1_HUMAN 0 GO:0003677; GO:0006284; GO:0030154; GO:0005737; GO:0016574; GO:0005634; GO:0006513; GO:0000209; GO:0042787; GO:0004842 Q8N726; P04637; Q13107 DNA binding; base-excision repair; cell differentiation; cytoplasm; histone ubiquitination; nucleus; protein monoubiquitination; protein polyubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR016024; IPR025527; IPR010309; IPR010314; IPR000569; IPR009060; IPR015940; IPR000449; IPR004170; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase HUWE1 (EC 6.3.2.-) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)" HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272 Homo sapiens (Human) TR42714_c0_g1_i3 Q7Z6Z7 HUWE1_HUMAN 0 GO:0003677; GO:0006284; GO:0030154; GO:0005737; GO:0016574; GO:0005634; GO:0006513; GO:0000209; GO:0042787; GO:0004842 Q8N726; P04637; Q13107 DNA binding; base-excision repair; cell differentiation; cytoplasm; histone ubiquitination; nucleus; protein monoubiquitination; protein polyubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR016024; IPR025527; IPR010309; IPR010314; IPR000569; IPR009060; IPR015940; IPR000449; IPR004170; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase HUWE1 (EC 6.3.2.-) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)" HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272 Homo sapiens (Human) TR42714_c1_g1_i1 Q7Z6Z7 HUWE1_HUMAN 9.00E-12 GO:0003677; GO:0006284; GO:0030154; GO:0005737; GO:0016574; GO:0005634; GO:0006513; GO:0000209; GO:0042787; GO:0004842 Q8N726; P04637; Q13107 DNA binding; base-excision repair; cell differentiation; cytoplasm; histone ubiquitination; nucleus; protein monoubiquitination; protein polyubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR016024; IPR025527; IPR010309; IPR010314; IPR000569; IPR009060; IPR015940; IPR000449; IPR004170; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase HUWE1 (EC 6.3.2.-) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)" HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272 Homo sapiens (Human) TR42715_c2_g2_i2 Q9GLY5 ITIH3_RABIT 4.00E-110 GO:0005576; GO:0030212; GO:0004867 extracellular region; hyaluronan metabolic process; serine-type endopeptidase inhibitor activity IPR010600; IPR013694; IPR002035; Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) ITIH3 Oryctolagus cuniculus (Rabbit) TR42716_c1_g2_i1 Q8RXN5 TYW1_ARATH 4.00E-23 GO:0051539; GO:0010181; GO:0005506; GO:0005739; GO:0016491; GO:0008033 "4 iron, 4 sulfur cluster binding; FMN binding; iron ion binding; mitochondrion; oxidoreductase activity; tRNA processing" IPR013785; IPR001094; IPR008254; IPR007197; IPR013917; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. tRNA wybutosine-synthesizing protein 1 homolog TYW1 At1g75200 F22H5.13 Arabidopsis thaliana (Mouse-ear cress) TR42716_c1_g3_i1 Q2KHP8 TYW1_XENLA 7.00E-44 GO:0051539; GO:0010181; GO:0005506; GO:0016491; GO:0008033 "4 iron, 4 sulfur cluster binding; FMN binding; iron ion binding; oxidoreductase activity; tRNA processing" IPR013785; IPR001094; IPR008254; IPR007197; IPR013917; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. tRNA wybutosine-synthesizing protein 1 homolog (Radical S-adenosyl methionine and flavodoxin domain-containing protein 1) (tRNA-yW-synthesizing protein) tyw1 rsafd1 Xenopus laevis (African clawed frog) TR42716_c1_g3_i2 Q08C92 TYW1_DANRE 0 GO:0051539; GO:0010181; GO:0005506; GO:0016491; GO:0008033 "4 iron, 4 sulfur cluster binding; FMN binding; iron ion binding; oxidoreductase activity; tRNA processing" IPR013785; IPR001094; IPR008254; IPR007197; IPR013917; tRNA modification; wybutosine-tRNA(Phe) biosynthesis. tRNA wybutosine-synthesizing protein 1 homolog (Radical S-adenosyl methionine and flavodoxin domain-containing protein 1) (tRNA-yW-synthesizing protein) tyw1 rsafd1 zgc:153368 Danio rerio (Zebrafish) (Brachydanio rerio) TR42716_c1_g3_i9 P00388 NCPR_RAT 7.00E-23 GO:0010181; GO:0050661; GO:0003958; GO:0009437; GO:0090346; GO:0071372; GO:0071375; GO:0004128; GO:0005829; GO:0070988; GO:0009055; GO:0005789; GO:0019899; GO:0019395; GO:0050660; GO:0009812; GO:0016787; GO:0018393; GO:0005506; GO:0047726; GO:0016020; GO:0005739; GO:0043066; GO:0043154; GO:0060192; GO:0043602; GO:0046210; GO:0008941; GO:0016709; GO:0045542; GO:0032332; GO:0032770; GO:0045880; GO:0090031; GO:0003420; GO:0042493; GO:0007584 "FMN binding; NADP binding; NADPH-hemoprotein reductase activity; carnitine metabolic process; cellular organofluorine metabolic process; cellular response to follicle-stimulating hormone stimulus; cellular response to peptide hormone stimulus; cytochrome-b5 reductase activity, acting on NAD(P)H; cytosol; demethylation; electron carrier activity; endoplasmic reticulum membrane; enzyme binding; fatty acid oxidation; flavin adenine dinucleotide binding; flavonoid metabolic process; hydrolase activity; internal peptidyl-lysine acetylation; iron ion binding; iron-cytochrome-c reductase activity; membrane; mitochondrion; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of lipase activity; nitrate catabolic process; nitric oxide catabolic process; nitric oxide dioxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; positive regulation of cholesterol biosynthetic process; positive regulation of chondrocyte differentiation; positive regulation of monooxygenase activity; positive regulation of smoothened signaling pathway; positive regulation of steroid hormone biosynthetic process; regulation of growth plate cartilage chondrocyte proliferation; response to drug; response to nutrient" IPR003097; IPR017927; IPR001094; IPR008254; IPR001709; IPR023173; IPR001433; IPR023208; IPR017938; NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4) Por Rattus norvegicus (Rat) TR42718_c0_g2_i1 Q80WC3 TNC18_MOUSE 8.00E-47 GO:0003677 DNA binding IPR001025; Trinucleotide repeat-containing gene 18 protein (Zinc finger protein 469) Tnrc18 Kiaa1856 Zfp469 Mus musculus (Mouse) TR42718_c0_g3_i1 Q9P281 BAHC1_HUMAN 2.00E-59 GO:0003677 DNA binding IPR001025; BAH and coiled-coil domain-containing protein 1 (Bromo adjacent homology domain-containing protein 2) (BAH domain-containing protein 2) BAHCC1 BAHD2 KIAA1447 Homo sapiens (Human) TR42718_c0_g3_i2 Q80WC3 TNC18_MOUSE 5.00E-53 GO:0003677 DNA binding IPR001025; Trinucleotide repeat-containing gene 18 protein (Zinc finger protein 469) Tnrc18 Kiaa1856 Zfp469 Mus musculus (Mouse) TR42718_c0_g3_i5 Q9P281 BAHC1_HUMAN 4.00E-57 GO:0003677 DNA binding IPR001025; BAH and coiled-coil domain-containing protein 1 (Bromo adjacent homology domain-containing protein 2) (BAH domain-containing protein 2) BAHCC1 BAHD2 KIAA1447 Homo sapiens (Human) TR42719_c1_g1_i1 O01510 SMG1_CAEEL 5.00E-18 GO:0016303; GO:0005524; GO:0005737; GO:0040035; GO:0030539; GO:0046872; GO:0000184; GO:0004674 "1-phosphatidylinositol-3-kinase activity; ATP binding; cytoplasm; hermaphrodite genitalia development; male genitalia development; metal ion binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; protein serine/threonine kinase activity" IPR011989; IPR016024; IPR003152; IPR011009; IPR000403; IPR014009; Serine/threonine-protein kinase smg-1 (EC 2.7.11.1) (Suppressor with morphogenetic effect on genitalia protein 1) smg-1 C48B6.6 Caenorhabditis elegans TR42719_c1_g1_i2 Q8BKX6 SMG1_MOUSE 1.00E-59 GO:0005524; GO:0006281; GO:0005737; GO:0046872; GO:0000184; GO:0005634; GO:0018105; GO:0046854; GO:0046777; GO:0004674 "ATP binding; DNA repair; cytoplasm; metal ion binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus; peptidyl-serine phosphorylation; phosphatidylinositol phosphorylation; protein autophosphorylation; protein serine/threonine kinase activity" IPR016024; IPR003152; IPR011009; IPR000403; IPR018936; IPR014009; Serine/threonine-protein kinase SMG1 (SMG-1) (EC 2.7.11.1) Smg1 Kiaa0421 Mus musculus (Mouse) TR42719_c1_g3_i5 Q8BKX6 SMG1_MOUSE 0 GO:0005524; GO:0006281; GO:0005737; GO:0046872; GO:0000184; GO:0005634; GO:0018105; GO:0046854; GO:0046777; GO:0004674 "ATP binding; DNA repair; cytoplasm; metal ion binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus; peptidyl-serine phosphorylation; phosphatidylinositol phosphorylation; protein autophosphorylation; protein serine/threonine kinase activity" IPR016024; IPR003152; IPR011009; IPR000403; IPR018936; IPR014009; Serine/threonine-protein kinase SMG1 (SMG-1) (EC 2.7.11.1) Smg1 Kiaa0421 Mus musculus (Mouse) TR42720_c5_g2_i2 Q5FVA9 RAE1L_XENTR 0 GO:0005737; GO:0005634 cytoplasm; nucleus IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; mRNA export factor (Rae1 protein homolog) (mRNA-associated protein mrnp 41) rae1 mrnp41 TEgg053e05.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42722_c0_g2_i1 Q5JU85 IQEC2_HUMAN 3.00E-117 GO:0005086; GO:0030036; GO:0030054; GO:0005737; GO:0005634; GO:0005543; GO:0032012 ARF guanyl-nucleotide exchange factor activity; actin cytoskeleton organization; cell junction; cytoplasm; nucleus; phospholipid binding; regulation of ARF protein signal transduction IPR000048; IPR011993; IPR001849; IPR023394; IPR000904; IQ motif and SEC7 domain-containing protein 2 IQSEC2 KIAA0522 Homo sapiens (Human) TR42722_c0_g2_i2 Q9BQI7 PSD2_HUMAN 4.00E-16 GO:0005086; GO:0030054; GO:0030425; GO:0016021; GO:0030182; GO:0043025; GO:0005543; GO:0032012 ARF guanyl-nucleotide exchange factor activity; cell junction; dendrite; integral to membrane; neuron differentiation; neuronal cell body; phospholipid binding; regulation of ARF protein signal transduction IPR001605; IPR011993; IPR001849; IPR023394; IPR000904; PH and SEC7 domain-containing protein 2 (Pleckstrin homology and SEC7 domain-containing protein 2) PSD2 Homo sapiens (Human) TR42722_c0_g2_i3 Q6DN90 IQEC1_HUMAN 2.00E-132 GO:0005086; GO:0030036; GO:0030054; GO:0005737; GO:0005730; GO:0005543; GO:0032012 ARF guanyl-nucleotide exchange factor activity; actin cytoskeleton organization; cell junction; cytoplasm; nucleolus; phospholipid binding; regulation of ARF protein signal transduction IPR000048; IPR011993; IPR001849; IPR023394; IPR000904; IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) IQSEC1 ARFGEP100 BRAG2 KIAA0763 Homo sapiens (Human) TR42722_c0_g2_i4 Q15438 CYH1_HUMAN 8.00E-32 GO:0005086; GO:0005737; GO:0090162; GO:0005543; GO:0005886; GO:0032012; GO:0030155; GO:0005923; GO:0016192 O60759 ARF guanyl-nucleotide exchange factor activity; cytoplasm; establishment of epithelial cell polarity; phospholipid binding; plasma membrane; regulation of ARF protein signal transduction; regulation of cell adhesion; tight junction; vesicle-mediated transport IPR011993; IPR001849; IPR023394; IPR000904; "Cytohesin-1 (PH, SEC7 and coiled-coil domain-containing protein 1) (SEC7 homolog B2-1)" CYTH1 D17S811E PSCD1 Homo sapiens (Human) TR42722_c0_g2_i5 Q9UIA0 CYH4_HUMAN 5.00E-30 GO:0005086; GO:0005543; GO:0005886; GO:0032012; GO:0030155 ARF guanyl-nucleotide exchange factor activity; phospholipid binding; plasma membrane; regulation of ARF protein signal transduction; regulation of cell adhesion IPR011993; IPR001849; IPR023394; IPR000904; "Cytohesin-4 (PH, SEC7 and coiled-coil domain-containing protein 4)" CYTH4 CYT4 PSCD4 Homo sapiens (Human) TR42722_c0_g2_i6 Q6DN90 IQEC1_HUMAN 1.00E-126 GO:0005086; GO:0030036; GO:0030054; GO:0005737; GO:0005730; GO:0005543; GO:0032012 ARF guanyl-nucleotide exchange factor activity; actin cytoskeleton organization; cell junction; cytoplasm; nucleolus; phospholipid binding; regulation of ARF protein signal transduction IPR000048; IPR011993; IPR001849; IPR023394; IPR000904; IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) IQSEC1 ARFGEP100 BRAG2 KIAA0763 Homo sapiens (Human) TR42723_c0_g1_i1 Q9EPU0 RENT1_MOUSE 0 GO:0005524; GO:0004004; GO:0003677; GO:0006281; GO:0006260; GO:0003723; GO:0000785; GO:0003682; GO:0000932; GO:0009048; GO:0071044; GO:0000184; GO:0005634; GO:0006449; GO:0008270 "ATP binding; ATP-dependent RNA helicase activity; DNA binding; DNA repair; DNA replication; RNA binding; chromatin; chromatin binding; cytoplasmic mRNA processing body; dosage compensation by inactivation of X chromosome; histone mRNA catabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus; regulation of translational termination; zinc ion binding" IPR027417; IPR018999; Regulator of nonsense transcripts 1 (EC 3.6.4.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (mUpf1) Upf1 Rent1 Mus musculus (Mouse) TR42723_c0_g1_i2 Q9EPU0 RENT1_MOUSE 0 GO:0005524; GO:0004004; GO:0003677; GO:0006281; GO:0006260; GO:0003723; GO:0000785; GO:0003682; GO:0000932; GO:0009048; GO:0071044; GO:0000184; GO:0005634; GO:0006449; GO:0008270 "ATP binding; ATP-dependent RNA helicase activity; DNA binding; DNA repair; DNA replication; RNA binding; chromatin; chromatin binding; cytoplasmic mRNA processing body; dosage compensation by inactivation of X chromosome; histone mRNA catabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus; regulation of translational termination; zinc ion binding" IPR027417; IPR018999; Regulator of nonsense transcripts 1 (EC 3.6.4.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (mUpf1) Upf1 Rent1 Mus musculus (Mouse) TR42723_c0_g1_i3 Q98TR3 RENT1_TAKRU 0 GO:0005524; GO:0003677; GO:0003723; GO:0000932; GO:0004386; GO:0000184; GO:0008270 "ATP binding; DNA binding; RNA binding; cytoplasmic mRNA processing body; helicase activity; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; zinc ion binding" IPR027417; IPR018999; Putative regulator of nonsense transcripts 1 (EC 3.6.4.-) (ATP-dependent helicase RENT1) rent1 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR42724_c1_g1_i1 Q91687 ITA4_XENLA 2.00E-40 GO:0007155; GO:0008305; GO:0007229; GO:0046872 cell adhesion; integrin complex; integrin-mediated signaling pathway; metal ion binding IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha-4 (Integrin alpha-IV) (VLA-4 subunit alpha) itga4 Xenopus laevis (African clawed frog) TR42724_c1_g1_i4 Q91687 ITA4_XENLA 9.00E-14 GO:0007155; GO:0008305; GO:0007229; GO:0046872 cell adhesion; integrin complex; integrin-mediated signaling pathway; metal ion binding IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha-4 (Integrin alpha-IV) (VLA-4 subunit alpha) itga4 Xenopus laevis (African clawed frog) TR42726_c4_g1_i1 B2RU80 PTPRB_MOUSE 7.00E-88 GO:0001525; GO:0016021; GO:0035335; GO:0004725 angiogenesis; integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) Ptprb Mus musculus (Mouse) TR42726_c4_g1_i3 Q98902 L1CAM_TAKRU 4.00E-07 GO:0007155; GO:0016021; GO:0005886 cell adhesion; integral to membrane; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR026966; Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (L1-CAM) l1cam Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR42726_c4_g1_i4 Q62656 PTPRZ_RAT 2.00E-60 GO:0016021; GO:0035335; GO:0004725 integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR001148; IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (3F8 chondroitin sulfate proteoglycan) (3H1 keratan sulfate proteoglycan) (Phosphacan) Ptprz1 Ptprz Ptpz Rattus norvegicus (Rat) TR42726_c4_g1_i5 Q58EX2 SDK2_HUMAN 7.00E-10 GO:0007155; GO:0016021 cell adhesion; integral to membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013151; Protein sidekick-2 SDK2 KIAA1514 Homo sapiens (Human) TR42726_c4_g1_i6 B2RU80 PTPRB_MOUSE 2.00E-90 GO:0001525; GO:0016021; GO:0035335; GO:0004725 angiogenesis; integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) Ptprb Mus musculus (Mouse) TR42727_c0_g2_i5 Q6P9K8 CSKI1_MOUSE 1.00E-39 GO:0005737 cytoplasm IPR002110; IPR020683; IPR027013; IPR027001; IPR001660; IPR013761; IPR021129; IPR011511; IPR001452; Caskin-1 (CASK-interacting protein 1) Caskin1 Kiaa1306 Mus musculus (Mouse) TR42727_c0_g2_i6 Q6P9K8 CSKI1_MOUSE 1.00E-39 GO:0005737 cytoplasm IPR002110; IPR020683; IPR027013; IPR027001; IPR001660; IPR013761; IPR021129; IPR011511; IPR001452; Caskin-1 (CASK-interacting protein 1) Caskin1 Kiaa1306 Mus musculus (Mouse) TR42727_c0_g2_i9 Q6P9K8 CSKI1_MOUSE 1.00E-39 GO:0005737 cytoplasm IPR002110; IPR020683; IPR027013; IPR027001; IPR001660; IPR013761; IPR021129; IPR011511; IPR001452; Caskin-1 (CASK-interacting protein 1) Caskin1 Kiaa1306 Mus musculus (Mouse) TR42728_c2_g1_i1 Q96J94 PIWL1_HUMAN 0 GO:0043186; GO:0033391; GO:0031047; GO:0003729; GO:0005845; GO:0007126; GO:0007275; GO:0034584; GO:0034587; GO:0005844; GO:0006417; GO:0003727; GO:0007286 Q9UPY3 P granule; chromatoid body; gene silencing by RNA; mRNA binding; mRNA cap binding complex; meiosis; multicellular organismal development; piRNA binding; piRNA metabolic process; polysome; regulation of translation; single-stranded RNA binding; spermatid development IPR008625; IPR003100; IPR003165; IPR012337; Piwi-like protein 1 PIWIL1 HIWI Homo sapiens (Human) TR42728_c2_g1_i10 Q96J94 PIWL1_HUMAN 0 GO:0043186; GO:0033391; GO:0031047; GO:0003729; GO:0005845; GO:0007126; GO:0007275; GO:0034584; GO:0034587; GO:0005844; GO:0006417; GO:0003727; GO:0007286 Q9UPY3 P granule; chromatoid body; gene silencing by RNA; mRNA binding; mRNA cap binding complex; meiosis; multicellular organismal development; piRNA binding; piRNA metabolic process; polysome; regulation of translation; single-stranded RNA binding; spermatid development IPR008625; IPR003100; IPR003165; IPR012337; Piwi-like protein 1 PIWIL1 HIWI Homo sapiens (Human) TR42728_c2_g1_i4 Q96J94 PIWL1_HUMAN 0 GO:0043186; GO:0033391; GO:0031047; GO:0003729; GO:0005845; GO:0007126; GO:0007275; GO:0034584; GO:0034587; GO:0005844; GO:0006417; GO:0003727; GO:0007286 Q9UPY3 P granule; chromatoid body; gene silencing by RNA; mRNA binding; mRNA cap binding complex; meiosis; multicellular organismal development; piRNA binding; piRNA metabolic process; polysome; regulation of translation; single-stranded RNA binding; spermatid development IPR008625; IPR003100; IPR003165; IPR012337; Piwi-like protein 1 PIWIL1 HIWI Homo sapiens (Human) TR42729_c0_g6_i2 O88974 SETB1_MOUSE 9.00E-93 GO:0003677; GO:0060348; GO:0005694; GO:0018024; GO:0001833; GO:0005634; GO:0006355; GO:0006351; GO:0008270 P81270 "DNA binding; bone development; chromosome; histone-lysine N-methyltransferase activity; inner cell mass cell proliferation; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR016177; IPR025796; IPR001739; IPR003616; IPR007728; IPR003606; IPR001214; IPR002999; Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.43) (ERG-associated protein with SET domain) (ESET) (SET domain bifurcated 1) Setdb1 Eset Kiaa0067 Mus musculus (Mouse) TR42730_c0_g1_i1 Q03601 NHL1_CAEEL 7.00E-82 GO:0008270 G5EFS1; O62482 zinc ion binding IPR011042; IPR001258; IPR013017; IPR018957; IPR001841; IPR013083; IPR017907; RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans TR42730_c0_g1_i11 Q03601 NHL1_CAEEL 2.00E-82 GO:0008270 G5EFS1; O62482 zinc ion binding IPR011042; IPR001258; IPR013017; IPR018957; IPR001841; IPR013083; IPR017907; RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans TR42730_c0_g1_i12 Q5ZMD4 TRI59_CHICK 3.00E-10 GO:0016021; GO:0005622; GO:0008270 integral to membrane; intracellular; zinc ion binding IPR000315; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 59 TRIM59 RCJMB04_2h17 Gallus gallus (Chicken) TR42730_c0_g1_i4 Q5ZMD4 TRI59_CHICK 5.00E-10 GO:0016021; GO:0005622; GO:0008270 integral to membrane; intracellular; zinc ion binding IPR000315; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 59 TRIM59 RCJMB04_2h17 Gallus gallus (Chicken) TR42730_c0_g1_i5 Q03601 NHL1_CAEEL 6.00E-82 GO:0008270 G5EFS1; O62482 zinc ion binding IPR011042; IPR001258; IPR013017; IPR018957; IPR001841; IPR013083; IPR017907; RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans TR42730_c0_g1_i6 P83388 AMDL_CAEEL 2.00E-07 GO:0005507; GO:0005576; GO:0016020; GO:0006518; GO:0004598; GO:0004504 copper ion binding; extracellular region; membrane; peptide metabolic process; peptidylamidoglycolate lyase activity; peptidylglycine monooxygenase activity IPR011042; IPR014784; IPR014783; IPR000323; IPR001258; IPR013017; IPR000720; IPR008977; Probable peptidyl-glycine alpha-amidating monooxygenase T19B4.1 (PAM) [Includes: Probable peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Probable peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)] T19B4.1 Caenorhabditis elegans TR42730_c0_g1_i7 Q5ZMD4 TRI59_CHICK 5.00E-10 GO:0016021; GO:0005622; GO:0008270 integral to membrane; intracellular; zinc ion binding IPR000315; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 59 TRIM59 RCJMB04_2h17 Gallus gallus (Chicken) TR42730_c0_g1_i8 P83388 AMDL_CAEEL 3.00E-07 GO:0005507; GO:0005576; GO:0016020; GO:0006518; GO:0004598; GO:0004504 copper ion binding; extracellular region; membrane; peptide metabolic process; peptidylamidoglycolate lyase activity; peptidylglycine monooxygenase activity IPR011042; IPR014784; IPR014783; IPR000323; IPR001258; IPR013017; IPR000720; IPR008977; Probable peptidyl-glycine alpha-amidating monooxygenase T19B4.1 (PAM) [Includes: Probable peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Probable peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)] T19B4.1 Caenorhabditis elegans TR42730_c0_g1_i9 Q03601 NHL1_CAEEL 1.00E-82 GO:0008270 G5EFS1; O62482 zinc ion binding IPR011042; IPR001258; IPR013017; IPR018957; IPR001841; IPR013083; IPR017907; RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans TR42731_c2_g5_i5 P61244 MAX_HUMAN 5.00E-41 GO:0071339; GO:0016605; GO:0071375; GO:0009267; GO:0005737; GO:0030425; GO:0010629; GO:0051402; GO:0006461; GO:0048678; GO:0032868; GO:0060041; GO:0043565; GO:0003700; GO:0003713; GO:0006366 Q99814; P02794; Q9UBS5; Q9Y6D9; P01106; P04198 MLL1 complex; PML body; cellular response to peptide hormone stimulus; cellular response to starvation; cytoplasm; dendrite; negative regulation of gene expression; neuron apoptotic process; protein complex assembly; response to axon injury; response to insulin stimulus; retina development in camera-type eye; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription from RNA polymerase II promoter IPR011598; Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X) MAX BHLHD4 Homo sapiens (Human) TR42732_c2_g2_i1 Q16881 TRXR1_HUMAN 0 GO:0016174; GO:0050661; GO:0070995; GO:0042537; GO:0008283; GO:0045454; GO:0044255; GO:0071280; GO:0071455; GO:0005829; GO:0009055; GO:0050660; GO:0006749; GO:0070276; GO:0042744; GO:0045340; GO:0001707; GO:0042191; GO:0005739; GO:0043025; GO:0015949; GO:0005730; GO:0001890; GO:0010942; GO:0015035; GO:0051262; GO:0048678; GO:0042493; GO:0010269; GO:0033797; GO:0016259; GO:0007165; GO:0004791 Q03135 NAD(P)H oxidase activity; NADP binding; NADPH oxidation; benzene-containing compound metabolic process; cell proliferation; cell redox homeostasis; cellular lipid metabolic process; cellular response to copper ion; cellular response to hyperoxia; cytosol; electron carrier activity; flavin adenine dinucleotide binding; glutathione metabolic process; halogen metabolic process; hydrogen peroxide catabolic process; mercury ion binding; mesoderm formation; methylmercury metabolic process; mitochondrion; neuronal cell body; nucleobase-containing small molecule interconversion; nucleolus; placenta development; positive regulation of cell death; protein disulfide oxidoreductase activity; protein tetramerization; response to axon injury; response to drug; response to selenium ion; selenate reductase activity; selenocysteine metabolic process; signal transduction; thioredoxin-disulfide reductase activity IPR016156; IPR013027; IPR002109; IPR004099; IPR023753; IPR012999; IPR001327; IPR012336; IPR006338; "Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Thioredoxin reductase TR1)" TXNRD1 GRIM12 KDRF Homo sapiens (Human) TR42732_c2_g4_i1 Q9ZR41 GLRX_SOLLC 8.00E-18 GO:0005794; GO:0048046; GO:0008794; GO:0045454; GO:0005829; GO:0009055; GO:0005886; GO:0015035; GO:0005773 Golgi apparatus; apoplast; arsenate reductase (glutaredoxin) activity; cell redox homeostasis; cytosol; electron carrier activity; plasma membrane; protein disulfide oxidoreductase activity; vacuole IPR011767; IPR002109; IPR011899; IPR014025; IPR012336; Glutaredoxin Solanum lycopersicum (Tomato) (Lycopersicon esculentum) TR42734_c0_g2_i1 O43184 ADA12_HUMAN 4.00E-84 GO:0007155; GO:0007173; GO:0005576; GO:0016021; GO:0004222; GO:0008237; GO:0005739; GO:0007520; GO:0005634; GO:0005886; GO:0006508; GO:0008270 O95633 cell adhesion; epidermal growth factor receptor signaling pathway; extracellular region; integral to membrane; metalloendopeptidase activity; metallopeptidase activity; mitochondrion; myoblast fusion; nucleus; plasma membrane; proteolysis; zinc ion binding IPR006586; IPR001762; IPR018358; IPR000742; IPR024079; IPR001590; IPR002870; Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (EC 3.4.24.-) (Meltrin-alpha) ADAM12 MLTN UNQ346/PRO545 Homo sapiens (Human) TR42734_c0_g2_i2 P82942 VM3K_NAJKA 2.00E-59 GO:0005576; GO:0046872; GO:0004222; GO:0006508 extracellular region; metal ion binding; metalloendopeptidase activity; proteolysis IPR006586; IPR001762; IPR024079; IPR001590; Hemorrhagic metalloproteinase-disintegrin-like kaouthiagin (EC 3.4.24.-) (Snake venom metalloproteinase) (SVMP) Naja kaouthia (Monocled cobra) (Naja siamensis) TR42737_c1_g3_i3 Q7RTU9 STRC_HUMAN 1.00E-20 GO:0060088; GO:0009986; GO:0050910; GO:0060091; GO:0032420; GO:0032426 auditory receptor cell stereocilium organization; cell surface; detection of mechanical stimulus involved in sensory perception of sound; kinocilium; stereocilium; stereocilium bundle tip IPR026061; IPR026664; Stereocilin STRC Homo sapiens (Human) TR42737_c1_g3_i4 Q8K561 OTOAN_MOUSE 9.00E-20 GO:0031225; GO:0016324; GO:0007160; GO:0005578; GO:0007605; GO:0019226 anchored to membrane; apical plasma membrane; cell-matrix adhesion; proteinaceous extracellular matrix; sensory perception of sound; transmission of nerve impulse IPR026663; IPR026664; Otoancorin Otoa Mus musculus (Mouse) TR42738_c0_g1_i1 O95163 ELP1_HUMAN 0 GO:0016591; GO:0033588; GO:0005737; GO:0006955; GO:0005730; GO:0008607; GO:0030335; GO:0006461; GO:0006468; GO:0006357; GO:0004871; GO:0008023; GO:0006368 Q9H9T3; P42858; Q15306 "DNA-directed RNA polymerase II, holoenzyme; Elongator holoenzyme complex; cytoplasm; immune response; nucleolus; phosphorylase kinase regulator activity; positive regulation of cell migration; protein complex assembly; protein phosphorylation; regulation of transcription from RNA polymerase II promoter; signal transducer activity; transcription elongation factor complex; transcription elongation from RNA polymerase II promoter" IPR011042; IPR006849; Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) (p150) IKBKAP ELP1 IKAP Homo sapiens (Human) TR42738_c0_g1_i4 O95163 ELP1_HUMAN 0 GO:0016591; GO:0033588; GO:0005737; GO:0006955; GO:0005730; GO:0008607; GO:0030335; GO:0006461; GO:0006468; GO:0006357; GO:0004871; GO:0008023; GO:0006368 Q9H9T3; P42858; Q15306 "DNA-directed RNA polymerase II, holoenzyme; Elongator holoenzyme complex; cytoplasm; immune response; nucleolus; phosphorylase kinase regulator activity; positive regulation of cell migration; protein complex assembly; protein phosphorylation; regulation of transcription from RNA polymerase II promoter; signal transducer activity; transcription elongation factor complex; transcription elongation from RNA polymerase II promoter" IPR011042; IPR006849; Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) (p150) IKBKAP ELP1 IKAP Homo sapiens (Human) TR42739_c0_g1_i4 A0JNA3 IMDH1_BOVIN 0 GO:0003677; GO:0006177; GO:0003938; GO:0030554; GO:0005737; GO:0046872; GO:0005634 DNA binding; GMP biosynthetic process; IMP dehydrogenase activity; adenyl nucleotide binding; cytoplasm; metal ion binding; nucleus IPR013785; IPR000644; IPR005990; IPR015875; IPR001093; Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1. Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) IMPDH1 Bos taurus (Bovine) TR42739_c0_g1_i6 P20839 IMDH1_HUMAN 3.00E-14 GO:0003677; GO:0006177; GO:0003938; GO:0003723; GO:0030554; GO:0005829; GO:0046651; GO:0046872; GO:0005634; GO:0006144; GO:0009168; GO:0009409; GO:0060041 DNA binding; GMP biosynthetic process; IMP dehydrogenase activity; RNA binding; adenyl nucleotide binding; cytosol; lymphocyte proliferation; metal ion binding; nucleus; purine nucleobase metabolic process; purine ribonucleoside monophosphate biosynthetic process; response to cold; retina development in camera-type eye IPR013785; IPR000644; IPR005990; IPR015875; IPR001093; Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1. Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I) IMPDH1 IMPD1 Homo sapiens (Human) TR42740_c1_g1_i1 Q7ZW47 STAU2_DANRE 2.00E-125 GO:0003723; GO:0005874; GO:0006810 RNA binding; microtubule; transport IPR014720; Double-stranded RNA-binding protein Staufen homolog 2 stau2 zgc:55287 Danio rerio (Zebrafish) (Brachydanio rerio) TR42740_c1_g1_i2 Q9Z108 STAU1_MOUSE 2.00E-60 GO:0003723; GO:0010494; GO:0008298; GO:0005791 RNA binding; cytoplasmic stress granule; intracellular mRNA localization; rough endoplasmic reticulum IPR014720; Double-stranded RNA-binding protein Staufen homolog 1 Stau1 Stau Mus musculus (Mouse) TR42740_c1_g1_i3 P25159 STAU_DROME 1.00E-29 GO:0045179; GO:0016324; GO:0055059; GO:0045167; GO:0045180; GO:0009925; GO:0045450; GO:0000932; GO:0003725; GO:0060293; GO:0007616; GO:0003730; GO:0005875; GO:0008017; GO:0007017; GO:0007400; GO:0045451; GO:0007318; GO:0010606; GO:0046012; GO:0007317 apical cortex; apical plasma membrane; asymmetric neuroblast division; asymmetric protein localization involved in cell fate determination; basal cortex; basal plasma membrane; bicoid mRNA localization; cytoplasmic mRNA processing body; double-stranded RNA binding; germ plasm; long-term memory; mRNA 3'-UTR binding; microtubule associated complex; microtubule binding; microtubule-based process; neuroblast fate determination; pole plasm oskar mRNA localization; pole plasm protein localization; positive regulation of cytoplasmic mRNA processing body assembly; positive regulation of oskar mRNA translation; regulation of pole plasm oskar mRNA localization IPR014720; Maternal effect protein staufen stau CG5753 Drosophila melanogaster (Fruit fly) TR42740_c1_g1_i4 Q7ZW47 STAU2_DANRE 2.00E-115 GO:0003723; GO:0005874; GO:0006810 RNA binding; microtubule; transport IPR014720; Double-stranded RNA-binding protein Staufen homolog 2 stau2 zgc:55287 Danio rerio (Zebrafish) (Brachydanio rerio) TR42743_c0_g1_i1 Q923Q2 STA13_MOUSE 2.00E-86 GO:0005096; GO:0007049; GO:0008289; GO:0005811; GO:0031966; GO:0043547; GO:0007165 GTPase activator activity; cell cycle; lipid binding; lipid particle; mitochondrial membrane; positive regulation of GTPase activity; signal transduction IPR008936; IPR000198; IPR013761; IPR023393; IPR002913; StAR-related lipid transfer protein 13 (START domain-containing protein 13) (StARD13) Stard13 Mus musculus (Mouse) TR42743_c0_g3_i2 B9VTT2 RHG07_CANFA 6.00E-99 GO:0005096; GO:0005737; GO:0005925; GO:0008289; GO:0016020; GO:0043547; GO:0007165 GTPase activator activity; cytoplasm; focal adhesion; lipid binding; membrane; positive regulation of GTPase activity; signal transduction IPR008936; IPR000198; IPR013761; IPR011510; IPR023393; IPR002913; Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein homolog) (DLC-1) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) DLC1 ARHGAP7 STARD12 Canis familiaris (Dog) (Canis lupus familiaris) TR42744_c0_g2_i1 Q5T200 ZC3HD_HUMAN 1.00E-16 GO:0046872 Q9P0W5 metal ion binding IPR000571; Zinc finger CCCH domain-containing protein 13 ZC3H13 KIAA0853 Homo sapiens (Human) TR42744_c0_g4_i1 Q5T200 ZC3HD_HUMAN 2.00E-09 GO:0046872 Q9P0W5 metal ion binding IPR000571; Zinc finger CCCH domain-containing protein 13 ZC3H13 KIAA0853 Homo sapiens (Human) TR42748_c1_g2_i2 Q39VS4 SYFB_GEOMG 9.00E-20 GO:0005524; GO:0005737; GO:0000287; GO:0004826; GO:0006432; GO:0000049; GO:0008033 ATP binding; cytoplasm; magnesium ion binding; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding; tRNA processing IPR005146; IPR009061; IPR012340; IPR004532; IPR020825; IPR005121; IPR002547; IPR005147; Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS) pheT Gmet_1416 Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210) TR42748_c1_g2_i3 Q9WUA2 SYFB_MOUSE 0 GO:0005524; GO:0003723; GO:0005737; GO:0000287; GO:0004826; GO:0006432 ATP binding; RNA binding; cytoplasm; magnesium ion binding; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation IPR005146; IPR009061; IPR004531; IPR020825; IPR005147; Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS) Farsb Farsl Farslb Frsb Mus musculus (Mouse) TR42748_c1_g2_i5 Q9VCA5 SYFB_DROME 0 GO:0005524; GO:0003723; GO:0005737; GO:0000287; GO:0004826; GO:0006432 ATP binding; RNA binding; cytoplasm; magnesium ion binding; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation IPR005146; IPR009061; IPR004531; IPR020825; IPR005147; Probable phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS) CG5706 Drosophila melanogaster (Fruit fly) TR42748_c1_g2_i6 Q9WUA2 SYFB_MOUSE 0 GO:0005524; GO:0003723; GO:0005737; GO:0000287; GO:0004826; GO:0006432 ATP binding; RNA binding; cytoplasm; magnesium ion binding; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation IPR005146; IPR009061; IPR004531; IPR020825; IPR005147; Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS) Farsb Farsl Farslb Frsb Mus musculus (Mouse) TR42749_c0_g4_i4 Q8BTY8 SCFD2_MOUSE 2.00E-42 GO:0015031; GO:0006904 protein transport; vesicle docking involved in exocytosis IPR027482; IPR001619; Sec1 family domain-containing protein 2 (Neuronal Sec1) (Syntaxin-binding protein 1-like 1) Scfd2 Stxbp1l1 Mus musculus (Mouse) TR4275_c1_g1_i1 Q9Y4D8 HECD4_HUMAN 6.00E-52 GO:0005737; GO:0016021; GO:0005634; GO:0042787; GO:0004842 cytoplasm; integral to membrane; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000569; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HECTD4 (EC 6.3.2.-) (HECT domain-containing protein 4) HECTD4 C12orf51 KIAA0614 Homo sapiens (Human) TR42750_c5_g1_i1 Q54QR7 GRN_DICDI 4.00E-11 GO:0005576 extracellular region IPR000118; Granulin grn DDB_G0283671 Dictyostelium discoideum (Slime mold) TR42750_c5_g1_i2 P28799 GRN_HUMAN 7.00E-33 GO:0001835; GO:0008219; GO:0007566; GO:0005615; GO:0008083; GO:0043231; GO:0005739; GO:0050679; GO:0007165 O00555; P09022; P19438; P20333 blastocyst hatching; cell death; embryo implantation; extracellular space; growth factor activity; intracellular membrane-bounded organelle; mitochondrion; positive regulation of epithelial cell proliferation; signal transduction IPR006150; IPR000118; Granulins (Proepithelin) (PEPI) [Cleaved into: Acrogranin (Glycoprotein of 88 Kda) (Progranulin); Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] GRN Homo sapiens (Human) TR42750_c5_g1_i3 P80059 PMD1_LOCMI 4.00E-07 GO:0005576; GO:0007218 extracellular region; neuropeptide signaling pathway IPR000118; Pars intercerebralis major peptide D1 (PMP-D1) Locusta migratoria (Migratory locust) TR42751_c0_g1_i6 Q18823 LAM2_CAEEL 4.00E-17 GO:0040017 positive regulation of locomotion IPR002049; IPR008979; IPR018031; IPR000034; IPR008211; Laminin-like protein lam-2 lam-2 C54D1.5 Caenorhabditis elegans TR42751_c0_g1_i7 A0JP86 LAMC1_XENTR 4.00E-33 GO:0005604; GO:0007155 basement membrane; cell adhesion IPR002049; IPR018031; IPR000034; IPR008211; Laminin subunit gamma-1 lamc1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42751_c0_g2_i1 Q1LVF0 LAMC1_DANRE 0 GO:0005604; GO:0007155; GO:0050908; GO:0048570; GO:0007634; GO:0031290; GO:0007519 basement membrane; cell adhesion; detection of light stimulus involved in visual perception; notochord morphogenesis; optokinetic behavior; retinal ganglion cell axon guidance; skeletal muscle tissue development IPR002049; IPR018031; IPR000034; IPR008211; Laminin subunit gamma-1 lamc1 Danio rerio (Zebrafish) (Brachydanio rerio) TR42751_c0_g2_i2 Q90922 NET1_CHICK 1.00E-111 GO:0071944; GO:0005578 Q9ERC8 cell periphery; proteinaceous extracellular matrix IPR002049; IPR008979; IPR008211; IPR001134; IPR018933; IPR008993; Netrin-1 NTN1 Gallus gallus (Chicken) TR42751_c0_g2_i3 P15215 LAMC1_DROME 0 GO:0005605; GO:0007155 basal lamina; cell adhesion IPR013032; IPR002049; IPR008979; IPR018031; IPR000034; IPR008211; Laminin subunit gamma-1 (Laminin B2 chain) LanB2 LAMC1 LAMG1 CG3322 Drosophila melanogaster (Fruit fly) TR42752_c1_g1_i1 Q14118 DAG1_HUMAN 7.00E-32 GO:0006607; GO:0042169; GO:0003779; GO:0051393; GO:0005604; GO:0060445; GO:0005509; GO:0030054; GO:0009279; GO:0070938; GO:0005737; GO:0007016; GO:0005856; GO:0016011; GO:0016010; GO:0060441; GO:0030198; GO:0005615; GO:0030175; GO:0016021; GO:0030027; GO:0043237; GO:0006509; GO:0045121; GO:0034453; GO:0019048; GO:0002011; GO:0022011; GO:0043409; GO:0030336; GO:0051898; GO:0021682; GO:0033268; GO:0005654; GO:0045211; GO:0009615; GO:0042383; GO:0008307; GO:0015631; GO:0001618 Q3T1J5; P16333 NLS-bearing protein import into nucleus; SH2 domain binding; actin binding; alpha-actinin binding; basement membrane; branching involved in salivary gland morphogenesis; calcium ion binding; cell junction; cell outer membrane; contractile ring; cytoplasm; cytoskeletal anchoring at plasma membrane; cytoskeleton; dystroglycan complex; dystrophin-associated glycoprotein complex; epithelial tube branching involved in lung morphogenesis; extracellular matrix organization; extracellular space; filopodium; integral to membrane; lamellipodium; laminin-1 binding; membrane protein ectodomain proteolysis; membrane raft; microtubule anchoring; modulation by virus of host morphology or physiology; morphogenesis of an epithelial sheet; myelination in peripheral nervous system; negative regulation of MAPK cascade; negative regulation of cell migration; negative regulation of protein kinase B signaling cascade; nerve maturation; node of Ranvier; nucleoplasm; postsynaptic membrane; response to virus; sarcolemma; structural constituent of muscle; tubulin binding; virus receptor activity IPR027468; IPR006644; IPR015919; IPR008465; IPR013783; Dystroglycan (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] DAG1 Homo sapiens (Human) TR42752_c1_g1_i6 Q14118 DAG1_HUMAN 3.00E-17 GO:0006607; GO:0042169; GO:0003779; GO:0051393; GO:0005604; GO:0060445; GO:0005509; GO:0030054; GO:0009279; GO:0070938; GO:0005737; GO:0007016; GO:0005856; GO:0016011; GO:0016010; GO:0060441; GO:0030198; GO:0005615; GO:0030175; GO:0016021; GO:0030027; GO:0043237; GO:0006509; GO:0045121; GO:0034453; GO:0019048; GO:0002011; GO:0022011; GO:0043409; GO:0030336; GO:0051898; GO:0021682; GO:0033268; GO:0005654; GO:0045211; GO:0009615; GO:0042383; GO:0008307; GO:0015631; GO:0001618 Q3T1J5; P16333 NLS-bearing protein import into nucleus; SH2 domain binding; actin binding; alpha-actinin binding; basement membrane; branching involved in salivary gland morphogenesis; calcium ion binding; cell junction; cell outer membrane; contractile ring; cytoplasm; cytoskeletal anchoring at plasma membrane; cytoskeleton; dystroglycan complex; dystrophin-associated glycoprotein complex; epithelial tube branching involved in lung morphogenesis; extracellular matrix organization; extracellular space; filopodium; integral to membrane; lamellipodium; laminin-1 binding; membrane protein ectodomain proteolysis; membrane raft; microtubule anchoring; modulation by virus of host morphology or physiology; morphogenesis of an epithelial sheet; myelination in peripheral nervous system; negative regulation of MAPK cascade; negative regulation of cell migration; negative regulation of protein kinase B signaling cascade; nerve maturation; node of Ranvier; nucleoplasm; postsynaptic membrane; response to virus; sarcolemma; structural constituent of muscle; tubulin binding; virus receptor activity IPR027468; IPR006644; IPR015919; IPR008465; IPR013783; Dystroglycan (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] DAG1 Homo sapiens (Human) TR42754_c0_g1_i1 P49587 PCY1_PLAFK 2.00E-17 GO:0006657; GO:0004105 CDP-choline pathway; choline-phosphate cytidylyltransferase activity IPR004821; IPR014729; Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2. Choline-phosphate cytidylyltransferase (EC 2.7.7.15) (CTP:phosphocholine cytidylyltransferase) (CCT) (CT) (Phosphorylcholine transferase) CTP Plasmodium falciparum (isolate K1 / Thailand) TR42754_c0_g1_i2 Q99447 PCY2_HUMAN 2.00E-84 GO:0005789; GO:0004306; GO:0006646; GO:0044281 endoplasmic reticulum membrane; ethanolamine-phosphate cytidylyltransferase activity; phosphatidylethanolamine biosynthetic process; small molecule metabolic process IPR004821; IPR014729; Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3. Ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase) PCYT2 Homo sapiens (Human) TR42754_c0_g3_i1 P49583 PCY1_CAEEL 5.00E-07 GO:0004105 choline-phosphate cytidylyltransferase activity IPR004821; IPR014729; Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2. Putative choline-phosphate cytidylyltransferase (EC 2.7.7.15) (CTP:phosphocholine cytidylyltransferase) (CCT) (CT) (Phosphorylcholine transferase) F08C6.2 Caenorhabditis elegans TR42754_c0_g3_i2 Q99447 PCY2_HUMAN 1.00E-50 GO:0005789; GO:0004306; GO:0006646; GO:0044281 endoplasmic reticulum membrane; ethanolamine-phosphate cytidylyltransferase activity; phosphatidylethanolamine biosynthetic process; small molecule metabolic process IPR004821; IPR014729; Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3. Ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase) PCYT2 Homo sapiens (Human) TR42754_c0_g3_i4 Q99447 PCY2_HUMAN 1.00E-50 GO:0005789; GO:0004306; GO:0006646; GO:0044281 endoplasmic reticulum membrane; ethanolamine-phosphate cytidylyltransferase activity; phosphatidylethanolamine biosynthetic process; small molecule metabolic process IPR004821; IPR014729; Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3. Ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase) PCYT2 Homo sapiens (Human) TR42755_c2_g4_i2 Q99M15 PPIP2_MOUSE 2.00E-28 GO:0003779; GO:0005856; GO:0007010; GO:0005829; GO:0016020 Q61152 actin binding; cytoskeleton; cytoskeleton organization; cytosol; membrane IPR001060; Proline-serine-threonine phosphatase-interacting protein 2 (PEST phosphatase-interacting protein 2) (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37) Pstpip2 Mayp Mus musculus (Mouse) TR42755_c2_g4_i4 P97814 PPIP1_MOUSE 1.00E-37 GO:0003779; GO:0005826; GO:0007155; GO:0032154; GO:0030027; GO:0048471; GO:0019903; GO:0001725 P00520; P35831; Q61152 actin binding; actomyosin contractile ring; cell adhesion; cleavage furrow; lamellipodium; perinuclear region of cytoplasm; protein phosphatase binding; stress fiber IPR001060; IPR001452; IPR013315; Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) Pstpip1 Mus musculus (Mouse) TR42757_c2_g1_i12 Q00438 PTBP1_RAT 6.00E-25 GO:0003723; GO:0008380; GO:0004519; GO:0006397; GO:0048025; GO:0051148; GO:0000166; GO:0005634; GO:0000381; GO:0003697 "RNA binding; RNA splicing; endonuclease activity; mRNA processing; negative regulation of mRNA splicing, via spliceosome; negative regulation of muscle cell differentiation; nucleotide binding; nucleus; regulation of alternative mRNA splicing, via spliceosome; single-stranded DNA binding" IPR006536; IPR012677; IPR000504; Polypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I) (Pyrimidine-binding protein) (PYBP) Ptbp1 Ptb Pybp Tbfii Rattus norvegicus (Rat) TR42757_c2_g1_i16 Q8WVV9 HNRLL_HUMAN 1.00E-75 GO:0003729; GO:0006397; GO:0000166; GO:0005634; GO:0033120; GO:0030529 mRNA binding; mRNA processing; nucleotide binding; nucleus; positive regulation of RNA splicing; ribonucleoprotein complex IPR006536; IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor) HNRNPLL HNRPLL SRRF BLOCK24 Homo sapiens (Human) TR42757_c2_g1_i7 Q8WVV9 HNRLL_HUMAN 8.00E-74 GO:0003729; GO:0006397; GO:0000166; GO:0005634; GO:0033120; GO:0030529 mRNA binding; mRNA processing; nucleotide binding; nucleus; positive regulation of RNA splicing; ribonucleoprotein complex IPR006536; IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor) HNRNPLL HNRPLL SRRF BLOCK24 Homo sapiens (Human) TR42758_c1_g5_i1 P86789 GIGA6_CRAGI 2.00E-46 GO:0016021 integral to membrane IPR001466; IPR012338; Gigasin-6 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) TR42760_c1_g1_i1 Q10068 YAN2_SCHPO 8.00E-12 GO:0005829; GO:0046872; GO:0004222; GO:0005634; GO:0006508 cytosol; metal ion binding; metalloendopeptidase activity; nucleus; proteolysis IPR011249; IPR011237; IPR011765; IPR007863; Uncharacterized protein C3H1.02c SPAC3H1.02c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42760_c1_g2_i1 Q7ZVZ6 PREP_DANRE 0 GO:0046872; GO:0004222; GO:0005759; GO:0006508 metal ion binding; metalloendopeptidase activity; mitochondrial matrix; proteolysis IPR011249; IPR011237; IPR011765; IPR007863; IPR013578; "Presequence protease, mitochondrial (EC 3.4.24.-) (Pitrilysin metalloproteinase 1)" pitrm1 zgc:55469 Danio rerio (Zebrafish) (Brachydanio rerio) TR42760_c1_g2_i2 Q4IA56 CYM1_GIBZE 3.00E-115 GO:0046872; GO:0008237; GO:0005739; GO:0051603 metal ion binding; metallopeptidase activity; mitochondrion; proteolysis involved in cellular protein catabolic process IPR011249; IPR011237; IPR011765; IPR007863; IPR013578; Mitochondrial presequence protease (EC 3.4.24.-) CYM1 FGSG_05902 Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum) TR42760_c1_g2_i5 Q7ZVZ6 PREP_DANRE 0 GO:0046872; GO:0004222; GO:0005759; GO:0006508 metal ion binding; metalloendopeptidase activity; mitochondrial matrix; proteolysis IPR011249; IPR011237; IPR011765; IPR007863; IPR013578; "Presequence protease, mitochondrial (EC 3.4.24.-) (Pitrilysin metalloproteinase 1)" pitrm1 zgc:55469 Danio rerio (Zebrafish) (Brachydanio rerio) TR42761_c0_g1_i1 P58215 LOXL3_HUMAN 3.00E-77 GO:0005507; GO:0001837; GO:0005576; GO:0005615; GO:0016020; GO:0045892; GO:0005634; GO:0004720; GO:0005044 "copper ion binding; epithelial to mesenchymal transition; extracellular region; extracellular space; membrane; negative regulation of transcription, DNA-dependent; nucleus; protein-lysine 6-oxidase activity; scavenger receptor activity" IPR001695; IPR019828; IPR001190; IPR017448; Lysyl oxidase homolog 3 (EC 1.4.3.-) (Lysyl oxidase-like protein 3) LOXL3 LOXL Homo sapiens (Human) TR42763_c3_g1_i3 A7Y2W8 SC6A9_XENLA 0 GO:0005887; GO:0005328; GO:0005283 integral to plasma membrane; neurotransmitter:sodium symporter activity; sodium:amino acid symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9) slc6a9 glyt1 Xenopus laevis (African clawed frog) TR42763_c3_g1_i4 Q28039 SC6A9_BOVIN 2.00E-32 GO:0005887; GO:0005328; GO:0005283 integral to plasma membrane; neurotransmitter:sodium symporter activity; sodium:amino acid symporter activity IPR000175; IPR003028; Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) SLC6A9 Bos taurus (Bovine) TR42763_c3_g1_i6 Q9JMA9 S6A14_MOUSE 1.00E-28 GO:0005275; GO:0006865; GO:0005887; GO:0005328; GO:0009636 amine transmembrane transporter activity; amino acid transport; integral to plasma membrane; neurotransmitter:sodium symporter activity; response to toxic substance IPR000175; Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Colonic system B0+ amino acid transporter CATB0+) (Solute carrier family 6 member 14) Slc6a14 Mus musculus (Mouse) TR42764_c0_g2_i12 Q9VYR0 LS12A_DROME 6.00E-27 IPR019181; Protein LSM12 homolog A CG15735 Drosophila melanogaster (Fruit fly) TR42764_c0_g2_i14 Q5RAT5 LSM12_PONAB 9.00E-53 IPR019181; Protein LSM12 homolog LSM12 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42764_c0_g2_i3 Q5RAT5 LSM12_PONAB 9.00E-53 IPR019181; Protein LSM12 homolog LSM12 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42764_c0_g2_i9 Q5RAT5 LSM12_PONAB 8.00E-54 IPR019181; Protein LSM12 homolog LSM12 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42766_c0_g1_i1 Q09575 YRD6_CAEEL 2.00E-19 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR42766_c0_g1_i3 P20825 POL2_DROME 4.00E-56 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) TR42766_c0_g3_i1 Q09575 YRD6_CAEEL 9.00E-28 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0008270 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; zinc ion binding IPR001584; IPR021109; IPR012337; IPR000477; IPR001878; Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans TR42766_c0_g3_i2 P16901 POL_OMVVS 2.00E-07 GO:0003677; GO:0015074; GO:0006310; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004170; GO:0046080; GO:0075713; GO:0004533; GO:0090305; GO:0006508; GO:0004523; GO:0046718; GO:0008270 DNA binding; DNA integration; DNA recombination; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; dUTP diphosphatase activity; dUTP metabolic process; establishment of integrated proviral latency; exoribonuclease H activity; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; viral entry into host cell; zinc ion binding IPR001969; IPR008180; IPR001037; IPR001584; IPR017856; IPR003308; IPR018061; IPR001995; IPR021109; IPR012337; IPR002156; IPR000477; IPR010659; IPR010661; Pol polyprotein [Cleaved into: Protease (EC 3.4.23.-) (Retropepsin); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2); Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23); Integrase (IN)] pol Ovine maedi visna related virus (strain South Africa) (SA-OMVV) (Ovine lentivirus) TR42767_c1_g1_i2 P22059 OSBP1_HUMAN 9.00E-16 GO:0000139; GO:0006869; GO:0008142; GO:0005543 Golgi membrane; lipid transport; oxysterol binding; phospholipid binding IPR000648; IPR018494; IPR011993; IPR001849; Oxysterol-binding protein 1 OSBP OSBP1 Homo sapiens (Human) TR42767_c1_g1_i3 Q6NRZ4 C43BP_XENLA 3.00E-166 GO:0005794; GO:0005783; GO:0006869; GO:0005543 Golgi apparatus; endoplasmic reticulum; lipid transport; phospholipid binding IPR011993; IPR001849; IPR023393; IPR002913; Collagen type IV alpha-3-binding protein (Ceramide transfer protein) col4a3bp Xenopus laevis (African clawed frog) TR42767_c1_g1_i4 Q6VVX2 C43BP_CRIGR 3.00E-178 GO:0035621; GO:0005794; GO:0005829; GO:0005783; GO:0070273 ER to Golgi ceramide transport; Golgi apparatus; cytosol; endoplasmic reticulum; phosphatidylinositol-4-phosphate binding IPR011993; IPR001849; IPR023393; IPR002913; Collagen type IV alpha-3-binding protein (Ceramide transfer protein) COL4A3BP CERT Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR42767_c1_g1_i5 Q5U3N0 PKHA8_DANRE 5.00E-17 GO:0005794; GO:0051861; GO:0046836; GO:0017089; GO:0016020; GO:0005543; GO:0015031 Golgi apparatus; glycolipid binding; glycolipid transport; glycolipid transporter activity; membrane; phospholipid binding; protein transport IPR014830; IPR011993; IPR001849; Pleckstrin homology domain-containing family A member 8 (PH domain-containing family A member 8) plekha8 zgc:101886 Danio rerio (Zebrafish) (Brachydanio rerio) TR42767_c1_g1_i6 Q6VVX2 C43BP_CRIGR 2.00E-116 GO:0035621; GO:0005794; GO:0005829; GO:0005783; GO:0070273 ER to Golgi ceramide transport; Golgi apparatus; cytosol; endoplasmic reticulum; phosphatidylinositol-4-phosphate binding IPR011993; IPR001849; IPR023393; IPR002913; Collagen type IV alpha-3-binding protein (Ceramide transfer protein) COL4A3BP CERT Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR42768_c1_g1_i1 Q8WW43 APH1B_HUMAN 1.00E-52 GO:0007220; GO:0007219; GO:0097190; GO:0016021; GO:0031293; GO:0048011; GO:0008233; GO:0005886; GO:0043065; GO:0043085; GO:0016485; GO:0030133 Notch receptor processing; Notch signaling pathway; apoptotic signaling pathway; integral to membrane; membrane protein intracellular domain proteolysis; neurotrophin TRK receptor signaling pathway; peptidase activity; plasma membrane; positive regulation of apoptotic process; positive regulation of catalytic activity; protein processing; transport vesicle IPR009294; Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta) (Presenilin-stabilization factor-like) APH1B PSFL UNQ688/PRO1328 Homo sapiens (Human) TR42768_c1_g1_i12 Q9VQG2 APH1_DROME 3.00E-11 GO:0007219; GO:0004175; GO:0005887; GO:0043085; GO:0016485 Notch signaling pathway; endopeptidase activity; integral to plasma membrane; positive regulation of catalytic activity; protein processing IPR009294; Gamma-secretase subunit Aph-1 (Presenilin-stabilization factor) aph-1 PSF CG2855 Drosophila melanogaster (Fruit fly) TR42768_c1_g1_i5 Q9VQG2 APH1_DROME 1.00E-69 GO:0007219; GO:0004175; GO:0005887; GO:0043085; GO:0016485 Notch signaling pathway; endopeptidase activity; integral to plasma membrane; positive regulation of catalytic activity; protein processing IPR009294; Gamma-secretase subunit Aph-1 (Presenilin-stabilization factor) aph-1 PSF CG2855 Drosophila melanogaster (Fruit fly) TR42768_c1_g1_i8 Q8BVF7 APH1A_MOUSE 5.00E-18 GO:0005794; GO:0007220; GO:0007219; GO:0042987; GO:0004175; GO:0005783; GO:0005789; GO:0005887; GO:0006509; GO:0031293; GO:0001656; GO:0043085; GO:0016485 Golgi apparatus; Notch receptor processing; Notch signaling pathway; amyloid precursor protein catabolic process; endopeptidase activity; endoplasmic reticulum; endoplasmic reticulum membrane; integral to plasma membrane; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; metanephros development; positive regulation of catalytic activity; protein processing IPR009294; Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) Aph1a Mus musculus (Mouse) TR42769_c0_g1_i1 Q9JLI3 MMEL1_MOUSE 6.00E-57 GO:0005794; GO:0005783; GO:0005615; GO:0016021; GO:0004222; GO:0006508; GO:0008270 Golgi apparatus; endoplasmic reticulum; extracellular space; integral to membrane; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR000718; IPR018497; IPR008753; "Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) (Neprilysin-like 1) (NL-1) (Neprilysin-like peptidase) (NEPLP) (Soluble secreted endopeptidase) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]" Mmel1 Nep2 Nl1 Sep Mus musculus (Mouse) TR42769_c0_g2_i3 P0C1T0 MMEL1_RAT 5.00E-84 GO:0005615; GO:0016021; GO:0016020; GO:0004222; GO:0006508; GO:0008270 extracellular space; integral to membrane; membrane; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR000718; IPR018497; IPR008753; "Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]" Mmel1 Mell1 Nep2 Rattus norvegicus (Rat) TR42769_c0_g2_i4 P08049 NEP_RABIT 4.00E-71 GO:0030424; GO:0050435; GO:0005903; GO:0071492; GO:0071493; GO:0071345; GO:0046449; GO:0030425; GO:0016021; GO:0001822; GO:0004222; GO:0044306; GO:0042277; GO:0005886; GO:0006508; GO:0090399; GO:0019233; GO:0008021; GO:0008270 axon; beta-amyloid metabolic process; brush border; cellular response to UV-A; cellular response to UV-B; cellular response to cytokine stimulus; creatinine metabolic process; dendrite; integral to membrane; kidney development; metalloendopeptidase activity; neuron projection terminus; peptide binding; plasma membrane; proteolysis; replicative senescence; sensory perception of pain; synaptic vesicle; zinc ion binding IPR024079; IPR000718; IPR018497; IPR008753; Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) MME Oryctolagus cuniculus (Rabbit) TR42770_c0_g1_i1 Q92896 GSLG1_HUMAN 0 GO:0000139; GO:0060349; GO:0031012; GO:0016021; GO:0010955; GO:0030512; GO:0005102; GO:0032330 Golgi membrane; bone morphogenesis; extracellular matrix; integral to membrane; negative regulation of protein processing; negative regulation of transforming growth factor beta receptor signaling pathway; receptor binding; regulation of chondrocyte differentiation IPR001893; IPR017873; Golgi apparatus protein 1 (CFR-1) (Cysteine-rich fibroblast growth factor receptor) (E-selectin ligand 1) (ESL-1) (Golgi sialoglycoprotein MG-160) GLG1 CFR1 ESL1 MG160 Homo sapiens (Human) TR42770_c0_g1_i5 Q92896 GSLG1_HUMAN 0 GO:0000139; GO:0060349; GO:0031012; GO:0016021; GO:0010955; GO:0030512; GO:0005102; GO:0032330 Golgi membrane; bone morphogenesis; extracellular matrix; integral to membrane; negative regulation of protein processing; negative regulation of transforming growth factor beta receptor signaling pathway; receptor binding; regulation of chondrocyte differentiation IPR001893; IPR017873; Golgi apparatus protein 1 (CFR-1) (Cysteine-rich fibroblast growth factor receptor) (E-selectin ligand 1) (ESL-1) (Golgi sialoglycoprotein MG-160) GLG1 CFR1 ESL1 MG160 Homo sapiens (Human) TR42771_c2_g1_i1 Q8I7C3 LASP1_DROME 3.00E-10 GO:0003779; GO:0005925; GO:0007279; GO:0045856; GO:0007291; GO:0070864; GO:0008270 actin binding; focal adhesion; pole cell formation; positive regulation of pole plasm oskar mRNA localization; sperm individualization; sperm individualization complex; zinc ion binding IPR000900; IPR001452; IPR001781; LIM and SH3 domain protein Lasp Lasp CG3849 Drosophila melanogaster (Fruit fly) TR42771_c2_g1_i2 Q63356 MYO1E_RAT 1.00E-20 GO:0005524; GO:0042623; GO:0051015; GO:0005912; GO:0005516; GO:0005911; GO:0030136; GO:0005737; GO:0005856; GO:0006897; GO:0032836; GO:0003094; GO:0072015; GO:0003774; GO:0016459; GO:0035091; GO:0043234 "ATP binding; ATPase activity, coupled; actin filament binding; adherens junction; calmodulin binding; cell-cell junction; clathrin-coated vesicle; cytoplasm; cytoskeleton; endocytosis; glomerular basement membrane development; glomerular filtration; glomerular visceral epithelial cell development; motor activity; myosin complex; phosphatidylinositol binding; protein complex" IPR000048; IPR001609; IPR010926; IPR027417; IPR001452; Unconventional myosin-Ie (Myosin heavy chain myr 3) (Unconventional myosin 1E) Myo1e Myr3 Rattus norvegicus (Rat) TR42771_c2_g2_i2 Q63356 MYO1E_RAT 0 GO:0005524; GO:0042623; GO:0051015; GO:0005912; GO:0005516; GO:0005911; GO:0030136; GO:0005737; GO:0005856; GO:0006897; GO:0032836; GO:0003094; GO:0072015; GO:0003774; GO:0016459; GO:0035091; GO:0043234 "ATP binding; ATPase activity, coupled; actin filament binding; adherens junction; calmodulin binding; cell-cell junction; clathrin-coated vesicle; cytoplasm; cytoskeleton; endocytosis; glomerular basement membrane development; glomerular filtration; glomerular visceral epithelial cell development; motor activity; myosin complex; phosphatidylinositol binding; protein complex" IPR000048; IPR001609; IPR010926; IPR027417; IPR001452; Unconventional myosin-Ie (Myosin heavy chain myr 3) (Unconventional myosin 1E) Myo1e Myr3 Rattus norvegicus (Rat) TR42771_c2_g2_i3 O00160 MYO1F_HUMAN 0 GO:0005524; GO:0003779; GO:0005516; GO:0030864; GO:0050830; GO:0031941; GO:0003774; GO:0007162; GO:0043312; GO:0030335; GO:0032956; GO:0045088; GO:0016461 ATP binding; actin binding; calmodulin binding; cortical actin cytoskeleton; defense response to Gram-positive bacterium; filamentous actin; motor activity; negative regulation of cell adhesion; neutrophil degranulation; positive regulation of cell migration; regulation of actin cytoskeleton organization; regulation of innate immune response; unconventional myosin complex IPR000048; IPR001609; IPR010926; IPR027417; IPR001452; Unconventional myosin-If (Myosin-Ie) MYO1F Homo sapiens (Human) TR42772_c5_g2_i1 P55214 CASP7_MESAU 5.00E-34 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR015471; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; "Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11; Caspase-7, N-terminally processed]" CASP7 MCH3 Mesocricetus auratus (Golden hamster) TR42772_c5_g2_i2 P45436 CED3_CAERE 5.00E-09 GO:0006915; GO:0004197; GO:0005622; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; intracellular; proteolysis; regulation of apoptotic process IPR001315; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Cell death protein 3 (EC 3.4.22.-) [Cleaved into: Cell death protein 3 subunit 1; Cell death protein 3 subunit 2] ced-3 Caenorhabditis remanei (Caenorhabditis vulgaris) TR42772_c5_g2_i4 P45436 CED3_CAERE 9.00E-22 GO:0006915; GO:0004197; GO:0005622; GO:0006508; GO:0042981 apoptotic process; cysteine-type endopeptidase activity; intracellular; proteolysis; regulation of apoptotic process IPR001315; IPR011029; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Cell death protein 3 (EC 3.4.22.-) [Cleaved into: Cell death protein 3 subunit 1; Cell death protein 3 subunit 2] ced-3 Caenorhabditis remanei (Caenorhabditis vulgaris) TR42772_c5_g2_i5 Q08DY9 CASP3_BOVIN 3.00E-41 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Bos taurus (Bovine) TR42776_c0_g1_i1 Q8R420 ABCA3_MOUSE 4.00E-74 GO:0005524; GO:0006200; GO:0016887; GO:0097233; GO:0016021; GO:0005886; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; alveolar lamellar body membrane; integral to membrane; plasma membrane; transport IPR003593; IPR026082; IPR003439; IPR017871; IPR026969; IPR027417; ATP-binding cassette sub-family A member 3 Abca3 Mus musculus (Mouse) TR42776_c0_g2_i2 Q9BZC7 ABCA2_HUMAN 0 GO:0005524; GO:0043190; GO:0042626; GO:0042632; GO:0016023; GO:0005768; GO:0010008; GO:0016021; GO:0006629; GO:0005765; GO:0005764; GO:0005815; GO:0032383; GO:0006357; GO:0042493; GO:0048545 "ATP binding; ATP-binding cassette (ABC) transporter complex; ATPase activity, coupled to transmembrane movement of substances; cholesterol homeostasis; cytoplasmic membrane-bounded vesicle; endosome; endosome membrane; integral to membrane; lipid metabolic process; lysosomal membrane; lysosome; microtubule organizing center; regulation of intracellular cholesterol transport; regulation of transcription from RNA polymerase II promoter; response to drug; response to steroid hormone stimulus" IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 2 (ATP-binding cassette transporter 2) (ATP-binding cassette 2) ABCA2 ABC2 KIAA1062 Homo sapiens (Human) TR42780_c1_g2_i1 Q5ZIJ9 MIB2_CHICK 4.00E-76 GO:0007219; GO:0005737; GO:0004842; GO:0008270 Notch signaling pathway; cytoplasm; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) TR42780_c1_g2_i2 Q9ULT8 HECD1_HUMAN 3.00E-08 GO:0005737; GO:0046872; GO:0001843; GO:0005634; GO:0042787; GO:0004842 cytoplasm; metal ion binding; neural tube closure; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR002110; IPR020683; IPR011989; IPR016024; IPR008979; IPR000569; IPR010606; IPR012919; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HECTD1 (EC 6.3.2.-) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) HECTD1 KIAA1131 Homo sapiens (Human) TR42780_c1_g2_i3 Q01484 ANK2_HUMAN 2.00E-13 GO:0051117; GO:0031430; GO:0030315; GO:0033292; GO:0030018; GO:0016324; GO:0003283; GO:0007411; GO:0016323; GO:0060048; GO:0006874; GO:0043034; GO:0005856; GO:0005829; GO:0005887; GO:0014704; GO:0044325; GO:0086046; GO:0048471; GO:1901021; GO:0051928; GO:2001259; GO:0010628; GO:1901018; GO:0043268; GO:0045211; GO:0015459; GO:0030674; GO:0036309; GO:0036371; GO:0034394; GO:0070972; GO:0050821; GO:0072661; GO:0086014; GO:0010881; GO:0086091; GO:0086005; GO:0060307; GO:0070296 P11532-5; P62993 "ATPase binding; M band; T-tubule; T-tubule organization; Z disc; apical plasma membrane; atrial septum development; axon guidance; basolateral plasma membrane; cardiac muscle contraction; cellular calcium ion homeostasis; costamere; cytoskeleton; cytosol; integral to plasma membrane; intercalated disc; ion channel binding; membrane depolarization involved in regulation of SA node cell action potential; perinuclear region of cytoplasm; positive regulation of calcium ion transmembrane transporter activity; positive regulation of calcium ion transport; positive regulation of cation channel activity; positive regulation of gene expression; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; postsynaptic membrane; potassium channel regulator activity; protein binding, bridging; protein localization to M-band; protein localization to T-tubule; protein localization to cell surface; protein localization to endoplasmic reticulum; protein stabilization; protein targeting to plasma membrane; regulation of atrial cardiac muscle cell action potential; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization; sarcoplasmic reticulum calcium ion transport" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) TR42780_c1_g2_i4 Q9BVR0 HRC23_HUMAN 2.00E-06 GO:0046872; GO:0004842 metal ion binding; ubiquitin-protein ligase activity IPR010606; Putative HERC2-like protein 3 HERC2P3 Homo sapiens (Human) TR42780_c1_g2_i7 Q5ZIJ9 MIB2_CHICK 9.00E-79 GO:0007219; GO:0005737; GO:0004842; GO:0008270 Notch signaling pathway; cytoplasm; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) TR42781_c1_g1_i1 Q58A65 JIP4_MOUSE 0 GO:0008432; GO:0007257; GO:0000187; GO:0005829; GO:0019894; GO:0048273; GO:0090074; GO:0048471; GO:0030335; GO:0045666; GO:0051260; GO:0042147; GO:0051146 P62331; Q5S007 "JUN kinase binding; activation of JUN kinase activity; activation of MAPK activity; cytosol; kinesin binding; mitogen-activated protein kinase p38 binding; negative regulation of protein homodimerization activity; perinuclear region of cytoplasm; positive regulation of cell migration; positive regulation of neuron differentiation; protein homooligomerization; retrograde transport, endosome to Golgi; striated muscle cell differentiation" IPR019143; IPR015943; IPR017986; C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (JNK-associated leucine-zipper protein) (JLP) (JNK/SAPK-associated protein 2) (JSAP2) (Mitogen-activated protein kinase 8-interacting protein 4) (Sperm-associated antigen 9) Spag9 Jip4 Jsap2 Kiaa0516 Mapk8ip4 Mus musculus (Mouse) TR42783_c0_g1_i3 Q6NU08 MTRAB_XENLA 4.00E-13 GO:0016791 phosphatase activity IPR010569; IPR022587; IPR017906; IPR011993; Myotubularin-related protein 10-B mtmr10-b Xenopus laevis (African clawed frog) TR42783_c1_g2_i1 O75208 COQ9_HUMAN 2.00E-63 GO:0005739; GO:0006744 mitochondrion; ubiquinone biosynthetic process IPR013718; IPR012762; Cofactor biosynthesis; ubiquinone biosynthesis. "Ubiquinone biosynthesis protein COQ9, mitochondrial" COQ9 C16orf49 HSPC326 PSEC0129 Homo sapiens (Human) TR42784_c0_g1_i2 Q80U93 NU214_MOUSE 3.00E-58 GO:0006406; GO:0005643; GO:0005487; GO:0006611; GO:0006606; GO:0051726 mRNA export from nucleus; nuclear pore; nucleocytoplasmic transporter activity; protein export from nucleus; protein import into nucleus; regulation of cell cycle IPR026054; IPR015943; IPR001680; Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) Nup214 Kiaa0023 Mus musculus (Mouse) TR42784_c0_g1_i3 P35658 NU214_HUMAN 1.00E-62 GO:0005975; GO:0019221; GO:0005829; GO:0010467; GO:0015758; GO:0006406; GO:0016071; GO:0007077; GO:0005643; GO:0005487; GO:0005654; GO:0006611; GO:0006606; GO:0051726; GO:0010827; GO:0044281; GO:0055085; GO:0005215; GO:0016032 carbohydrate metabolic process; cytokine-mediated signaling pathway; cytosol; gene expression; glucose transport; mRNA export from nucleus; mRNA metabolic process; mitotic nuclear envelope disassembly; nuclear pore; nucleocytoplasmic transporter activity; nucleoplasm; protein export from nucleus; protein import into nucleus; regulation of cell cycle; regulation of glucose transport; small molecule metabolic process; transmembrane transport; transporter activity; viral process IPR026054; IPR015943; IPR001680; Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN) NUP214 CAIN CAN KIAA0023 Homo sapiens (Human) TR42785_c1_g3_i1 Q8CEC0 NUP88_MOUSE 9.00E-83 GO:0051028; GO:0005643; GO:0015031 mRNA transport; nuclear pore; protein transport IPR019321; Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) Nup88 Mus musculus (Mouse) TR42786_c1_g1_i1 Q9ULB1 NRX1A_HUMAN 0 GO:0033130; GO:0030534; GO:0007411; GO:0005246; GO:0005509; GO:0007155; GO:0050839; GO:0030054; GO:0009986; GO:0030198; GO:0097116; GO:0005887; GO:0007612; GO:0097118; GO:0097109; GO:0050885; GO:0007269; GO:2000463; GO:0051965; GO:0090129; GO:0051968; GO:0097119; GO:0097104; GO:0060134; GO:0042734; GO:0004872; GO:2000821; GO:0035176; GO:0071625 "acetylcholine receptor binding; adult behavior; axon guidance; calcium channel regulator activity; calcium ion binding; cell adhesion; cell adhesion molecule binding; cell junction; cell surface; extracellular matrix organization; gephyrin clustering; integral to plasma membrane; learning; neuroligin clustering; neuroligin family protein binding; neuromuscular process controlling balance; neurotransmitter secretion; positive regulation of excitatory postsynaptic membrane potential; positive regulation of synapse assembly; positive regulation of synapse maturation; positive regulation of synaptic transmission, glutamatergic; postsynaptic density protein 95 clustering; postsynaptic membrane assembly; prepulse inhibition; presynaptic membrane; receptor activity; regulation of grooming behavior; social behavior; vocalization behavior" IPR008985; IPR013320; IPR000742; IPR000152; IPR001791; IPR003585; IPR027158; IPR027789; Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) NRXN1 KIAA0578 Homo sapiens (Human) TR42786_c1_g1_i3 A1XQX0 NR1AA_DANRE 7.00E-80 GO:0007155; GO:0016021; GO:0046872; GO:0007269; GO:0051965; GO:0090129; GO:0007416 cell adhesion; integral to membrane; metal ion binding; neurotransmitter secretion; positive regulation of synapse assembly; positive regulation of synapse maturation; synapse assembly IPR008985; IPR013320; IPR000742; IPR001791; IPR003585; IPR027158; IPR027789; Neurexin-1a (Neurexin Ia-alpha) (Neurexin-1a-alpha) nrxn1a Danio rerio (Zebrafish) (Brachydanio rerio) TR42788_c0_g1_i1 Q58CU2 E41L5_BOVIN 7.00E-168 GO:0005912; GO:0005737; GO:0005856; GO:0019898 adherens junction; cytoplasm; cytoskeleton; extrinsic to membrane IPR019749; IPR019750; IPR000798; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; Band 4.1-like protein 5 EPB41L5 Bos taurus (Bovine) TR42790_c2_g1_i2 Q9UGP8 SEC63_HUMAN 1.00E-12 GO:0006614; GO:0005783; GO:0005789; GO:0016021; GO:0001889; GO:0016020; GO:0010259; GO:0006807; GO:0006620; GO:0031204; GO:0008565; GO:0004872; GO:0072001 P97346 "SRP-dependent cotranslational protein targeting to membrane; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; liver development; membrane; multicellular organismal aging; nitrogen compound metabolic process; posttranslational protein targeting to membrane; posttranslational protein targeting to membrane, translocation; protein transporter activity; receptor activity; renal system development" IPR001623; IPR014756; IPR027137; IPR004179; Translocation protein SEC63 homolog SEC63 SEC63L Homo sapiens (Human) TR42790_c2_g2_i1 O75643 U520_HUMAN 0 GO:0005524; GO:0004004; GO:0005682; GO:0071013; GO:0000354; GO:0003676; GO:0005654 Itself; O15541 ATP binding; ATP-dependent RNA helicase activity; U5 snRNP; catalytic step 2 spliceosome; cis assembly of pre-catalytic spliceosome; nucleic acid binding; nucleoplasm IPR003593; IPR011545; IPR014001; IPR001650; IPR014756; IPR027417; IPR004179; U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) SNRNP200 ASCC3L1 HELIC2 KIAA0788 Homo sapiens (Human) TR42790_c2_g2_i2 O75643 U520_HUMAN 5.00E-136 GO:0005524; GO:0004004; GO:0005682; GO:0071013; GO:0000354; GO:0003676; GO:0005654 Itself; O15541 ATP binding; ATP-dependent RNA helicase activity; U5 snRNP; catalytic step 2 spliceosome; cis assembly of pre-catalytic spliceosome; nucleic acid binding; nucleoplasm IPR003593; IPR011545; IPR014001; IPR001650; IPR014756; IPR027417; IPR004179; U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) SNRNP200 ASCC3L1 HELIC2 KIAA0788 Homo sapiens (Human) TR42791_c1_g2_i1 O14788 TNF11_HUMAN 4.00E-07 GO:0070371; GO:0007257; GO:0045453; GO:0055074; GO:0005125; GO:0005737; GO:0005576; GO:0005615; GO:0006955; GO:0005887; GO:0060749; GO:0033598; GO:0002548; GO:0009887; GO:0001503; GO:0030316; GO:0002158; GO:0071848; GO:0043123; GO:0046330; GO:0043406; GO:0051092; GO:0050870; GO:0045780; GO:0051466; GO:0071812; GO:0034112; GO:0045672; GO:0051897; GO:0045944; GO:0051260; GO:0005164 ERK1 and ERK2 cascade; activation of JUN kinase activity; bone resorption; calcium ion homeostasis; cytokine activity; cytoplasm; extracellular region; extracellular space; immune response; integral to plasma membrane; mammary gland alveolus development; mammary gland epithelial cell proliferation; monocyte chemotaxis; organ morphogenesis; ossification; osteoclast differentiation; osteoclast proliferation; positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell activation; positive regulation of bone resorption; positive regulation of corticotropin-releasing hormone secretion; positive regulation of fever generation by positive regulation of prostaglandin secretion; positive regulation of homotypic cell-cell adhesion; positive regulation of osteoclast differentiation; positive regulation of protein kinase B signaling cascade; positive regulation of transcription from RNA polymerase II promoter; protein homooligomerization; tumor necrosis factor receptor binding IPR006052; IPR017355; IPR008983; "Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]" TNFSF11 OPGL RANKL TRANCE Homo sapiens (Human) TR42791_c1_g2_i3 O43557 TNF14_HUMAN 7.00E-13 GO:0031295; GO:0043029; GO:0042098; GO:0071260; GO:0043027; GO:0005737; GO:0005615; GO:0006955; GO:0016021; GO:0005886; GO:0005102; GO:0008588 Q92956; O95407 T cell costimulation; T cell homeostasis; T cell proliferation; cellular response to mechanical stimulus; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; extracellular space; immune response; integral to membrane; plasma membrane; receptor binding; release of cytoplasmic sequestered NF-kappaB IPR006053; IPR006052; IPR008983; "Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]" TNFSF14 HVEML LIGHT UNQ391/PRO726 Homo sapiens (Human) TR42791_c1_g2_i4 Q5UBV8 TNF15_MOUSE 8.00E-09 GO:0007250; GO:0006919; GO:0042107; GO:0005615; GO:0006955; GO:0016021; GO:0005886 activation of NF-kappaB-inducing kinase activity; activation of cysteine-type endopeptidase activity involved in apoptotic process; cytokine metabolic process; extracellular space; immune response; integral to membrane; plasma membrane IPR006053; IPR006052; IPR008064; IPR008983; Tumor necrosis factor ligand superfamily member 15 (TNF ligand-related molecule 1) (Vascular endothelial cell growth inhibitor) Tnfsf15 Tl1 Vegi Mus musculus (Mouse) TR42791_c1_g2_i6 P50592 TNF10_MOUSE 4.00E-11 GO:0005615; GO:0006955; GO:0016021; GO:0043123; GO:0043065; GO:0043280; GO:2001238; GO:0090200 extracellular space; immune response; integral to membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of release of cytochrome c from mitochondria IPR021184; IPR006052; IPR017355; IPR008983; Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253) Tnfsf10 Trail Mus musculus (Mouse) TR42791_c1_g2_i7 O43557 TNF14_HUMAN 6.00E-15 GO:0031295; GO:0043029; GO:0042098; GO:0071260; GO:0043027; GO:0005737; GO:0005615; GO:0006955; GO:0016021; GO:0005886; GO:0005102; GO:0008588 Q92956; O95407 T cell costimulation; T cell homeostasis; T cell proliferation; cellular response to mechanical stimulus; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; extracellular space; immune response; integral to membrane; plasma membrane; receptor binding; release of cytoplasmic sequestered NF-kappaB IPR006053; IPR006052; IPR008983; "Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]" TNFSF14 HVEML LIGHT UNQ391/PRO726 Homo sapiens (Human) TR42792_c0_g1_i1 P21333 FLNA_HUMAN 0 GO:0034988; GO:0031523; GO:0048365; GO:0017160; GO:0051764; GO:0015629; GO:0031532; GO:0051015; GO:0007195; GO:0005938; GO:0034329; GO:0042384; GO:0051220; GO:0005829; GO:0045022; GO:0001837; GO:0045184; GO:0070062; GO:0001948; GO:0042177; GO:0043433; GO:0005634; GO:0005886; GO:0030168; GO:0002576; GO:0043123; GO:0042993; GO:0042803; GO:0034394; GO:0050821; GO:0043113; GO:0004871; GO:0090307; GO:0005802 Q9WMX2; Q8N264; O95067; P46108; O75369; Q12948; P62993; P05556; P07228; P26010; O14786; P35372; Q86SQ0 Fc-gamma receptor I complex binding; Myb complex; Rac GTPase binding; Ral GTPase binding; actin crosslink formation; actin cytoskeleton; actin cytoskeleton reorganization; actin filament binding; adenylate cyclase-inhibiting dopamine receptor signaling pathway; cell cortex; cell junction assembly; cilium assembly; cytoplasmic sequestering of protein; cytosol; early endosome to late endosome transport; epithelial to mesenchymal transition; establishment of protein localization; extracellular vesicular exosome; glycoprotein binding; negative regulation of protein catabolic process; negative regulation of sequence-specific DNA binding transcription factor activity; nucleus; plasma membrane; platelet activation; platelet degranulation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor import into nucleus; protein homodimerization activity; protein localization to cell surface; protein stabilization; receptor clustering; signal transducer activity; spindle assembly involved in mitosis; trans-Golgi network IPR001589; IPR001715; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) FLNA FLN FLN1 Homo sapiens (Human) TR42792_c0_g1_i2 Q8BTM8 FLNA_MOUSE 0 GO:0034988; GO:0031523; GO:0048365; GO:0051764; GO:0031532; GO:0051015; GO:0007195; GO:0005938; GO:0030030; GO:0005737; GO:0051220; GO:0005856; GO:0045022; GO:0001837; GO:0045184; GO:0001948; GO:0042177; GO:0043433; GO:0005634; GO:0005886; GO:0043123; GO:0042993; GO:0005080; GO:0034394; GO:0050821; GO:0043113; GO:0004871; GO:0090307; GO:0005802; GO:0008134 Q8CIH5 Fc-gamma receptor I complex binding; Myb complex; Rac GTPase binding; actin crosslink formation; actin cytoskeleton reorganization; actin filament binding; adenylate cyclase-inhibiting dopamine receptor signaling pathway; cell cortex; cell projection organization; cytoplasm; cytoplasmic sequestering of protein; cytoskeleton; early endosome to late endosome transport; epithelial to mesenchymal transition; establishment of protein localization; glycoprotein binding; negative regulation of protein catabolic process; negative regulation of sequence-specific DNA binding transcription factor activity; nucleus; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor import into nucleus; protein kinase C binding; protein localization to cell surface; protein stabilization; receptor clustering; signal transducer activity; spindle assembly involved in mitosis; trans-Golgi network; transcription factor binding IPR001589; IPR001715; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Flna Fln Fln1 Mus musculus (Mouse) TR42792_c0_g1_i3 Q80X90 FLNB_MOUSE 0 GO:0030018; GO:0005938; GO:0005737; GO:0005925; GO:0007519; GO:0001725 Z disc; cell cortex; cytoplasm; focal adhesion; skeletal muscle tissue development; stress fiber IPR001589; IPR001715; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-B (FLN-B) (ABP-280-like protein) (Actin-binding-like protein) (Beta-filamin) Flnb Mus musculus (Mouse) TR42793_c1_g1_i1 O95477 ABCA1_HUMAN 0 GO:0005524; GO:0006200; GO:0016887; GO:0007186; GO:0005794; GO:0008509; GO:0034188; GO:0044255; GO:0071222; GO:0071300; GO:0015485; GO:0033344; GO:0042632; GO:0008203; GO:0017127; GO:0016197; GO:0034380; GO:0005887; GO:0050702; GO:0032367; GO:0042157; GO:0007040; GO:0045121; GO:0010887; GO:0010745; GO:0002790; GO:0045335; GO:0006911; GO:0005543; GO:0033700; GO:0055091; GO:0045332; GO:0005548; GO:0060155; GO:0030819; GO:0010875; GO:0006497; GO:0032489; GO:0034616; GO:0055098; GO:0043691 Q13424; Q13884 "ATP binding; ATP catabolic process; ATPase activity; G-protein coupled receptor signaling pathway; Golgi apparatus; anion transmembrane transporter activity; apolipoprotein A-I receptor activity; cellular lipid metabolic process; cellular response to lipopolysaccharide; cellular response to retinoic acid; cholesterol binding; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transporter activity; endosomal transport; high-density lipoprotein particle assembly; integral to plasma membrane; interleukin-1 beta secretion; intracellular cholesterol transport; lipoprotein metabolic process; lysosome organization; membrane raft; negative regulation of cholesterol storage; negative regulation of macrophage derived foam cell differentiation; peptide secretion; phagocytic vesicle; phagocytosis, engulfment; phospholipid binding; phospholipid efflux; phospholipid homeostasis; phospholipid translocation; phospholipid transporter activity; platelet dense granule organization; positive regulation of cAMP biosynthetic process; positive regulation of cholesterol efflux; protein lipidation; regulation of Cdc42 protein signal transduction; response to laminar fluid shear stress; response to low-density lipoprotein particle stimulus; reverse cholesterol transport" IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein) ABCA1 ABC1 CERP Homo sapiens (Human) TR42793_c1_g1_i2 Q91V24 ABCA7_MOUSE 4.00E-163 GO:0005524; GO:0006200; GO:0016887; GO:0000139; GO:0016324; GO:0010008; GO:0016021; GO:0005622; GO:0006909; GO:0033700; GO:0005548 ATP binding; ATP catabolic process; ATPase activity; Golgi membrane; apical plasma membrane; endosome membrane; integral to membrane; intracellular; phagocytosis; phospholipid efflux; phospholipid transporter activity IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 7 Abca7 Mus musculus (Mouse) TR42793_c1_g1_i3 O95477 ABCA1_HUMAN 0 GO:0005524; GO:0006200; GO:0016887; GO:0007186; GO:0005794; GO:0008509; GO:0034188; GO:0044255; GO:0071222; GO:0071300; GO:0015485; GO:0033344; GO:0042632; GO:0008203; GO:0017127; GO:0016197; GO:0034380; GO:0005887; GO:0050702; GO:0032367; GO:0042157; GO:0007040; GO:0045121; GO:0010887; GO:0010745; GO:0002790; GO:0045335; GO:0006911; GO:0005543; GO:0033700; GO:0055091; GO:0045332; GO:0005548; GO:0060155; GO:0030819; GO:0010875; GO:0006497; GO:0032489; GO:0034616; GO:0055098; GO:0043691 Q13424; Q13884 "ATP binding; ATP catabolic process; ATPase activity; G-protein coupled receptor signaling pathway; Golgi apparatus; anion transmembrane transporter activity; apolipoprotein A-I receptor activity; cellular lipid metabolic process; cellular response to lipopolysaccharide; cellular response to retinoic acid; cholesterol binding; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transporter activity; endosomal transport; high-density lipoprotein particle assembly; integral to plasma membrane; interleukin-1 beta secretion; intracellular cholesterol transport; lipoprotein metabolic process; lysosome organization; membrane raft; negative regulation of cholesterol storage; negative regulation of macrophage derived foam cell differentiation; peptide secretion; phagocytic vesicle; phagocytosis, engulfment; phospholipid binding; phospholipid efflux; phospholipid homeostasis; phospholipid translocation; phospholipid transporter activity; platelet dense granule organization; positive regulation of cAMP biosynthetic process; positive regulation of cholesterol efflux; protein lipidation; regulation of Cdc42 protein signal transduction; response to laminar fluid shear stress; response to low-density lipoprotein particle stimulus; reverse cholesterol transport" IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein) ABCA1 ABC1 CERP Homo sapiens (Human) TR42793_c1_g1_i4 Q54BT5 ABCA3_DICDI 2.00E-66 GO:0005524; GO:0042626; GO:0016021; GO:0031288 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; sorocarp morphogenesis" IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ABC transporter A family member 3 (ABC transporter ABCA.3) abcA3 DDB_G0293436 Dictyostelium discoideum (Slime mold) TR42793_c1_g1_i5 O95477 ABCA1_HUMAN 0 GO:0005524; GO:0006200; GO:0016887; GO:0007186; GO:0005794; GO:0008509; GO:0034188; GO:0044255; GO:0071222; GO:0071300; GO:0015485; GO:0033344; GO:0042632; GO:0008203; GO:0017127; GO:0016197; GO:0034380; GO:0005887; GO:0050702; GO:0032367; GO:0042157; GO:0007040; GO:0045121; GO:0010887; GO:0010745; GO:0002790; GO:0045335; GO:0006911; GO:0005543; GO:0033700; GO:0055091; GO:0045332; GO:0005548; GO:0060155; GO:0030819; GO:0010875; GO:0006497; GO:0032489; GO:0034616; GO:0055098; GO:0043691 Q13424; Q13884 "ATP binding; ATP catabolic process; ATPase activity; G-protein coupled receptor signaling pathway; Golgi apparatus; anion transmembrane transporter activity; apolipoprotein A-I receptor activity; cellular lipid metabolic process; cellular response to lipopolysaccharide; cellular response to retinoic acid; cholesterol binding; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transporter activity; endosomal transport; high-density lipoprotein particle assembly; integral to plasma membrane; interleukin-1 beta secretion; intracellular cholesterol transport; lipoprotein metabolic process; lysosome organization; membrane raft; negative regulation of cholesterol storage; negative regulation of macrophage derived foam cell differentiation; peptide secretion; phagocytic vesicle; phagocytosis, engulfment; phospholipid binding; phospholipid efflux; phospholipid homeostasis; phospholipid translocation; phospholipid transporter activity; platelet dense granule organization; positive regulation of cAMP biosynthetic process; positive regulation of cholesterol efflux; protein lipidation; regulation of Cdc42 protein signal transduction; response to laminar fluid shear stress; response to low-density lipoprotein particle stimulus; reverse cholesterol transport" IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein) ABCA1 ABC1 CERP Homo sapiens (Human) TR42795_c5_g1_i1 Q9W735 PRM1A_DANRE 2.00E-62 GO:0016324; GO:0016021 apical plasma membrane; integral to membrane IPR008795; Prominin-1-A (Prominin-like protein 1) prom1a proml1 Danio rerio (Zebrafish) (Brachydanio rerio) TR42795_c5_g1_i2 O43490 PROM1_HUMAN 4.00E-61 GO:0042805; GO:0016324; GO:0005903; GO:0060219; GO:0009986; GO:0005615; GO:0072139; GO:0072112; GO:0005887; GO:0031528; GO:0045494; GO:0042622; GO:0005886; GO:2000768; GO:0010842; GO:0032420 Q8VHP6 actinin binding; apical plasma membrane; brush border; camera-type eye photoreceptor cell differentiation; cell surface; extracellular space; glomerular parietal epithelial cell differentiation; glomerular visceral epithelial cell differentiation; integral to plasma membrane; microvillus membrane; photoreceptor cell maintenance; photoreceptor outer segment membrane; plasma membrane; positive regulation of nephron tubule epithelial cell differentiation; retina layer formation; stereocilium IPR008795; Prominin-1 (Antigen AC133) (Prominin-like protein 1) (CD antigen CD133) PROM1 PROML1 MSTP061 Homo sapiens (Human) TR42795_c5_g1_i3 Q9W735 PRM1A_DANRE 2.00E-63 GO:0016324; GO:0016021 apical plasma membrane; integral to membrane IPR008795; Prominin-1-A (Prominin-like protein 1) prom1a proml1 Danio rerio (Zebrafish) (Brachydanio rerio) TR42796_c0_g1_i2 Q2KIY1 PXMP2_BOVIN 6.00E-35 GO:0016021; GO:0005778; GO:0043234 integral to membrane; peroxisomal membrane; protein complex IPR007248; Peroxisomal membrane protein 2 PXMP2 Bos taurus (Bovine) TR42796_c0_g1_i4 A5D787 M17L2_BOVIN 4.00E-14 GO:0016021; GO:0005739 integral to membrane; mitochondrion IPR007248; Mpv17-like protein 2 MPV17L2 Bos taurus (Bovine) TR42797_c0_g2_i1 Q9BUJ2 HNRL1_HUMAN 2.00E-80 GO:0003723; GO:0000398; GO:0005654; GO:0006355; GO:0009615; GO:0030529; GO:0006351 Q9NPI1 "RNA binding; mRNA splicing, via spliceosome; nucleoplasm; regulation of transcription, DNA-dependent; response to virus; ribonucleoprotein complex; transcription, DNA-dependent" IPR001870; IPR008985; IPR027417; IPR003034; IPR018355; IPR003877; Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5) HNRNPUL1 E1BAP5 HNRPUL1 Homo sapiens (Human) TR42798_c0_g1_i1 Q00232 NU5M_MYTED 0 GO:0042773; GO:0008137; GO:0016021; GO:0005743; GO:0070469 ATP synthesis coupled electron transport; NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial inner membrane; respiratory chain IPR010934; IPR001750; IPR001516; NADH-ubiquinone oxidoreductase chain 5 (EC 1.6.5.3) (NADH dehydrogenase subunit 5) ND5 Mytilus edulis (Blue mussel) TR42798_c0_g2_i1 Q00232 NU5M_MYTED 0 GO:0042773; GO:0008137; GO:0016021; GO:0005743; GO:0070469 ATP synthesis coupled electron transport; NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial inner membrane; respiratory chain IPR010934; IPR001750; IPR001516; NADH-ubiquinone oxidoreductase chain 5 (EC 1.6.5.3) (NADH dehydrogenase subunit 5) ND5 Mytilus edulis (Blue mussel) TR42798_c0_g3_i1 Q00568 NU3M_MYTED 2.00E-50 GO:0008137; GO:0016021; GO:0031966; GO:0070469 NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial membrane; respiratory chain IPR000440; NADH-ubiquinone oxidoreductase chain 3 (EC 1.6.5.3) (NADH dehydrogenase subunit 3) ND3 Mytilus edulis (Blue mussel) TR42798_c0_g3_i2 P03877 SCE3_YEAST 5.00E-08 GO:0003677; GO:0008380; GO:0009060; GO:0004129; GO:0009055; GO:0004519; GO:0020037; GO:0016021; GO:0006314; GO:0005506; GO:0006397; GO:0005739 DNA binding; RNA splicing; aerobic respiration; cytochrome-c oxidase activity; electron carrier activity; endonuclease activity; heme binding; integral to membrane; intron homing; iron ion binding; mRNA processing; mitochondrion IPR000883; IPR023616; IPR001982; IPR027434; Intron-encoded DNA endonuclease aI3 (DNA endonuclease I-SceIII) [Cleaved into: Truncated non-functional cytochrome oxidase 1; DNA endonuclease aI3 (EC 3.1.-.-) (Intron-encoded endonuclease I-SceIII)] aI3 ENS3 I-SCEIII Q0060 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42798_c0_g4_i1 P41774 COX1_MYTED 0 GO:0009060; GO:0004129; GO:0009055; GO:0020037; GO:0016021; GO:0005506; GO:0005743; GO:0006119; GO:0070469 aerobic respiration; cytochrome-c oxidase activity; electron carrier activity; heme binding; integral to membrane; iron ion binding; mitochondrial inner membrane; oxidative phosphorylation; respiratory chain IPR000883; IPR023615; IPR023616; Energy metabolism; oxidative phosphorylation. Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide I) COI Mytilus edulis (Blue mussel) TR42798_c0_g4_i2 Q09333 COX1_ALBTU 1.00E-37 GO:0009060; GO:0004129; GO:0009055; GO:0020037; GO:0016021; GO:0005506; GO:0005743; GO:0006119; GO:0070469 aerobic respiration; cytochrome-c oxidase activity; electron carrier activity; heme binding; integral to membrane; iron ion binding; mitochondrial inner membrane; oxidative phosphorylation; respiratory chain IPR000883; IPR023616; Energy metabolism; oxidative phosphorylation. Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide I) (Fragment) COI Albinaria turrita (Door snail) (Clausilia turrita) TR42799_c0_g1_i1 Q9VT65 CANB_DROME 0 GO:0007298; GO:0005509; GO:0004198; GO:0005737; GO:0016020; GO:0016540; GO:0006508 P12370 border follicle cell migration; calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cytoplasm; membrane; protein autoprocessing; proteolysis IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-B (EC 3.4.22.-) (Calcium-activated neutral proteinase B) (CANP B) [Cleaved into: Calpain-B catalytic subunit 1; Calpain-B catalytic subunit 2] CalpB CG8107 Drosophila melanogaster (Fruit fly) TR42799_c0_g1_i2 Q9VT65 CANB_DROME 0 GO:0007298; GO:0005509; GO:0004198; GO:0005737; GO:0016020; GO:0016540; GO:0006508 P12370 border follicle cell migration; calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cytoplasm; membrane; protein autoprocessing; proteolysis IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-B (EC 3.4.22.-) (Calcium-activated neutral proteinase B) (CANP B) [Cleaved into: Calpain-B catalytic subunit 1; Calpain-B catalytic subunit 2] CalpB CG8107 Drosophila melanogaster (Fruit fly) TR42799_c0_g1_i3 Q3UW68 CAN13_MOUSE 3.00E-67 GO:0005509; GO:0004198; GO:0005622; GO:0006508 calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; intracellular; proteolysis IPR022684; IPR022682; IPR011992; IPR002048; IPR000169; IPR001300; Calpain-13 (EC 3.4.22.-) (Calcium-activated neutral proteinase 13) (CANP 13) Capn13 Gm943 Mus musculus (Mouse) TR42799_c0_g1_i4 P34308 CAN_CAEEL 2.00E-150 GO:0031430; GO:0004198; GO:0010940; GO:0006508 M band; calcium-dependent cysteine-type endopeptidase activity; positive regulation of necrotic cell death; proteolysis IPR022684; IPR022682; IPR022683; IPR000169; IPR001300; Calpain clp-1 (EC 3.4.22.-) clp-1 C06G4.2/C06G4.3 Caenorhabditis elegans TR42799_c0_g1_i5 O08688 CAN5_MOUSE 3.00E-107 GO:0004198; GO:0009986; GO:0005622; GO:0006508 calcium-dependent cysteine-type endopeptidase activity; cell surface; intracellular; proteolysis IPR000008; IPR022684; IPR022682; IPR022683; IPR000169; IPR001300; Calpain-5 (EC 3.4.22.-) (New calpain 3) (nCL-3) Capn5 Ncl3 Mus musculus (Mouse) TR42799_c0_g1_i6 Q9VT65 CANB_DROME 0 GO:0007298; GO:0005509; GO:0004198; GO:0005737; GO:0016020; GO:0016540; GO:0006508 P12370 border follicle cell migration; calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cytoplasm; membrane; protein autoprocessing; proteolysis IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-B (EC 3.4.22.-) (Calcium-activated neutral proteinase B) (CANP B) [Cleaved into: Calpain-B catalytic subunit 1; Calpain-B catalytic subunit 2] CalpB CG8107 Drosophila melanogaster (Fruit fly) TR42799_c0_g1_i7 Q92177 CAN3_CHICK 6.00E-121 GO:0030315; GO:0030018; GO:0005509; GO:0004198; GO:0071277; GO:0071472; GO:0005829; GO:0055103; GO:0043066; GO:0033234; GO:0045892; GO:0005634; GO:0051092; GO:0045862; GO:0051281; GO:0014718; GO:0045893; GO:0043234; GO:0006461; GO:0032947; GO:0072657; GO:0043122; GO:0014850; GO:0045214; GO:0097264; GO:0031402; GO:0008307; GO:0031432 "T-tubule; Z disc; calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cellular response to calcium ion; cellular response to salt stress; cytosol; ligase regulator activity; negative regulation of apoptotic process; negative regulation of protein sumoylation; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of proteolysis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of satellite cell activation involved in skeletal muscle regeneration; positive regulation of transcription, DNA-dependent; protein complex; protein complex assembly; protein complex scaffold; protein localization to membrane; regulation of I-kappaB kinase/NF-kappaB cascade; response to muscle activity; sarcomere organization; self proteolysis; sodium ion binding; structural constituent of muscle; titin binding" IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) CAPN3 Gallus gallus (Chicken) TR42799_c0_g1_i8 Q9VT65 CANB_DROME 0 GO:0007298; GO:0005509; GO:0004198; GO:0005737; GO:0016020; GO:0016540; GO:0006508 P12370 border follicle cell migration; calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cytoplasm; membrane; protein autoprocessing; proteolysis IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-B (EC 3.4.22.-) (Calcium-activated neutral proteinase B) (CANP B) [Cleaved into: Calpain-B catalytic subunit 1; Calpain-B catalytic subunit 2] CalpB CG8107 Drosophila melanogaster (Fruit fly) TR4280_c0_g1_i1 P52566 GDIR2_HUMAN 9.00E-15 GO:0005096; GO:0005094; GO:0007266; GO:0030036; GO:0006928; GO:0016023; GO:0005856; GO:0005829; GO:0006955; GO:0007275; GO:0007162; GO:0043547; GO:0051056 GTPase activator activity; Rho GDP-dissociation inhibitor activity; Rho protein signal transduction; actin cytoskeleton organization; cellular component movement; cytoplasmic membrane-bounded vesicle; cytoskeleton; cytosol; immune response; multicellular organismal development; negative regulation of cell adhesion; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction IPR014756; IPR000406; IPR024792; Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (Ly-GDI) (Rho-GDI beta) ARHGDIB GDIA2 GDID4 RAP1GN1 Homo sapiens (Human) TR42800_c0_g1_i2 P25940 CO5A3_HUMAN 7.00E-08 GO:0007411; GO:0007160; GO:0005518; GO:0030574; GO:0030199; GO:0005588; GO:0005788; GO:0022617; GO:0005201; GO:0008201; GO:0043588 axon guidance; cell-matrix adhesion; collagen binding; collagen catabolic process; collagen fibril organization; collagen type V; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular matrix structural constituent; heparin binding; skin development IPR008160; IPR008985; IPR013320; IPR000885; IPR001791; Collagen alpha-3(V) chain COL5A3 Homo sapiens (Human) TR42800_c0_g4_i1 P39059 COFA1_HUMAN 2.00E-52 GO:0001525; GO:0005604; GO:0007155; GO:0030154; GO:0030574; GO:0005582; GO:0005788; GO:0022617; GO:0005201; GO:0005615; GO:0016021; GO:0007165 angiogenesis; basement membrane; cell adhesion; cell differentiation; collagen catabolic process; collagen type XV; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular matrix structural constituent; extracellular space; integral to membrane; signal transduction IPR016186; IPR016187; IPR008160; IPR010515; IPR008985; IPR001791; Collagen alpha-1(XV) chain [Cleaved into: Restin (Endostatin-XV) (Related to endostatin) (Restin-I); Restin-2 (Restin-II); Restin-3 (Restin-III); Restin-4 (Restin-IV)] COL15A1 Homo sapiens (Human) TR42800_c0_g6_i2 O35206 COFA1_MOUSE 3.00E-22 GO:0005604; GO:0007155; GO:0005581; GO:0005615; GO:0005198 basement membrane; cell adhesion; collagen; extracellular space; structural molecule activity IPR016186; IPR016187; IPR008160; IPR010515; IPR008985; IPR013320; IPR001791; Collagen alpha-1(XV) chain [Cleaved into: Restin (Endostatin-XV)] Col15a1 Mus musculus (Mouse) TR42800_c0_g6_i3 P17140 CO4A2_CAEEL 8.00E-07 GO:0016043; GO:0005587; GO:0009792; GO:0030020 cellular component organization; collagen type IV; embryo development ending in birth or egg hatching; extracellular matrix structural constituent conferring tensile strength IPR016187; IPR008160; IPR001442; Collagen alpha-2(IV) chain (Lethal protein 2) let-2 clb-1 F01G12.5 Caenorhabditis elegans TR42800_c0_g6_i4 Q14031 CO4A6_HUMAN 2.00E-08 GO:0007155; GO:0071230; GO:0030574; GO:0005587; GO:0005788; GO:0022617; GO:0005201 cell adhesion; cellular response to amino acid stimulus; collagen catabolic process; collagen type IV; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular matrix structural constituent IPR016187; IPR008160; IPR001442; Collagen alpha-6(IV) chain COL4A6 Homo sapiens (Human) TR42801_c0_g3_i1 Q6ZV73 FGD6_HUMAN 7.00E-171 GO:0005794; GO:0005089; GO:0030036; GO:0005856; GO:0046847; GO:0005085; GO:0030027; GO:0046872; GO:0005543; GO:0043088; GO:0008360; GO:0001726; GO:0031267 Golgi apparatus; Rho guanyl-nucleotide exchange factor activity; actin cytoskeleton organization; cytoskeleton; filopodium assembly; guanyl-nucleotide exchange factor activity; lamellipodium; metal ion binding; phospholipid binding; regulation of Cdc42 GTPase activity; regulation of cell shape; ruffle; small GTPase binding IPR000219; IPR011993; IPR001849; IPR000306; IPR017455; IPR013083; "FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24)" FGD6 KIAA1362 ZFYVE24 Homo sapiens (Human) TR42801_c0_g3_i2 B4JHI7 LST2_DROGR 2.00E-14 GO:0046872 metal ion binding IPR000306; IPR017455; IPR011011; IPR013083; Lateral signaling target protein 2 homolog GH18624 Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) TR42801_c0_g3_i3 O95405 ZFYV9_HUMAN 1.00E-13 GO:0005545; GO:0007183; GO:0007184; GO:0031901; GO:0006897; GO:0046872; GO:0030512; GO:0008236; GO:0007179 Q9Y561; P62136; P08100; Q15796; P84022; Q13277 1-phosphatidylinositol binding; SMAD protein complex assembly; SMAD protein import into nucleus; early endosome membrane; endocytosis; metal ion binding; negative regulation of transforming growth factor beta receptor signaling pathway; serine-type peptidase activity; transforming growth factor beta receptor signaling pathway IPR022557; IPR024608; IPR000306; IPR017455; IPR011011; IPR017165; IPR013083; Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) ZFYVE9 MADHIP SARA SMADIP Homo sapiens (Human) TR42801_c0_g3_i4 Q96M96 FGD4_HUMAN 2.00E-85 GO:0005794; GO:0005089; GO:0015629; GO:0030036; GO:0097190; GO:0005829; GO:0030175; GO:0046847; GO:0005085; GO:0030027; GO:0030032; GO:0046872; GO:0030035; GO:0048011; GO:0005543; GO:0043065; GO:0043088; GO:0008360; GO:0001726; GO:0031267; GO:0007264 Golgi apparatus; Rho guanyl-nucleotide exchange factor activity; actin cytoskeleton; actin cytoskeleton organization; apoptotic signaling pathway; cytosol; filopodium; filopodium assembly; guanyl-nucleotide exchange factor activity; lamellipodium; lamellipodium assembly; metal ion binding; microspike assembly; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of apoptotic process; regulation of Cdc42 GTPase activity; regulation of cell shape; ruffle; small GTPase binding; small GTPase mediated signal transduction IPR000219; IPR011993; IPR001849; IPR000306; IPR017455; IPR013083; "FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6)" FGD4 FRABP ZFYVE6 Homo sapiens (Human) TR42802_c1_g1_i1 O95602 RPA1_HUMAN 0 GO:0003677; GO:0005736; GO:0003899; GO:0005654; GO:0006363; GO:0006362; GO:0006361; GO:0008270 P04626; Q9H9Y6 DNA binding; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase activity; nucleoplasm; termination of RNA polymerase I transcription; transcription elongation from RNA polymerase I promoter; transcription initiation from RNA polymerase I promoter; zinc ion binding IPR015699; IPR000722; IPR006592; IPR007080; IPR007066; IPR007083; IPR007081; DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194) POLR1A Homo sapiens (Human) TR42802_c1_g1_i3 O95602 RPA1_HUMAN 0 GO:0003677; GO:0005736; GO:0003899; GO:0005654; GO:0006363; GO:0006362; GO:0006361; GO:0008270 P04626; Q9H9Y6 DNA binding; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase activity; nucleoplasm; termination of RNA polymerase I transcription; transcription elongation from RNA polymerase I promoter; transcription initiation from RNA polymerase I promoter; zinc ion binding IPR015699; IPR000722; IPR006592; IPR007080; IPR007066; IPR007083; IPR007081; DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194) POLR1A Homo sapiens (Human) TR42802_c1_g2_i1 Q58446 RPOA2_METJA 6.00E-21 GO:0003677; GO:0003899; GO:0004519; GO:0016539; GO:0006314; GO:0090305; GO:0006351 "DNA binding; DNA-directed RNA polymerase activity; endonuclease activity; intein-mediated protein splicing; intron homing; nucleic acid phosphodiester bond hydrolysis; transcription, DNA-dependent" IPR003586; IPR003587; IPR027434; IPR006142; IPR004042; IPR006141; IPR007081; IPR012757; DNA-directed RNA polymerase subunit A'' (EC 2.7.7.6) [Cleaved into: Mja rpoA2 intein (Mja rpol A'' intein)] rpoA2 MJ1043 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR42802_c1_g2_i2 Q8ZYQ7 RPOA2_PYRAE 1.00E-22 GO:0003677; GO:0003899; GO:0006351 "DNA binding; DNA-directed RNA polymerase activity; transcription, DNA-dependent" IPR007081; IPR012757; DNA-directed RNA polymerase subunit A'' (EC 2.7.7.6) rpoA2 PAE0667 Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827) TR42804_c0_g1_i2 Q61805 LBP_MOUSE 5.00E-52 GO:0006953; GO:0009986; GO:0071223; GO:0050829; GO:0050830; GO:0032490; GO:0005615; GO:0045087; GO:0002232; GO:0001530; GO:0015920; GO:0031663; GO:0070891; GO:0002281; GO:0044130; GO:0032720; GO:0008228; GO:0032722; GO:0032755; GO:0032757; GO:0043032; GO:0090023; GO:0060265; GO:0034145; GO:0042535; GO:0032760; GO:0005102; GO:0032496 acute-phase response; cell surface; cellular response to lipoteichoic acid; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; detection of molecule of bacterial origin; extracellular space; innate immune response; leukocyte chemotaxis involved in inflammatory response; lipopolysaccharide binding; lipopolysaccharide transport; lipopolysaccharide-mediated signaling pathway; lipoteichoic acid binding; macrophage activation involved in immune response; negative regulation of growth of symbiont in host; negative regulation of tumor necrosis factor production; opsonization; positive regulation of chemokine production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of macrophage activation; positive regulation of neutrophil chemotaxis; positive regulation of respiratory burst involved in inflammatory response; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of tumor necrosis factor production; receptor binding; response to lipopolysaccharide IPR017943; IPR001124; IPR017954; IPR017942; Lipopolysaccharide-binding protein (LBP) Lbp Mus musculus (Mouse) TR42805_c1_g1_i1 Q90972 RNF13_CHICK 2.00E-57 GO:0016021; GO:0031902; GO:0005765; GO:0005634; GO:0051865; GO:0004842; GO:0008270 integral to membrane; late endosome membrane; lysosomal membrane; nucleus; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003137; IPR001841; IPR013083; E3 ubiquitin-protein ligase RNF13 (EC 6.3.2.-) (C-RZF) (RING finger protein 13) RNF13 RZF Gallus gallus (Chicken) TR42805_c1_g1_i3 Q641J8 RF12A_XENLA 6.00E-13 GO:0000578; GO:0005634; GO:0042787; GO:0004842; GO:0008270 embryonic axis specification; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF12-A (EC 6.3.2.-) (RING finger protein 12-A) (XRnf12) rnf12-a rnf12 Xenopus laevis (African clawed frog) TR42806_c3_g1_i2 Q8IZD6 S22AF_HUMAN 2.00E-25 GO:0016021; GO:0006811; GO:0022857 integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Solute carrier family 22 member 15 (Fly-like putative transporter 1) (Flipt 1) SLC22A15 FLIPT1 UNQ9429/PRO34686 Homo sapiens (Human) TR42806_c3_g1_i3 Q6NUB3 S22AF_XENLA 1.00E-30 GO:0016021; GO:0006811; GO:0022857 integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Solute carrier family 22 member 15 slc22a15 Xenopus laevis (African clawed frog) TR42806_c3_g1_i5 Q9VCA2 ORCT_DROME 5.00E-35 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR42806_c3_g1_i6 Q95R48 OCTL_DROME 4.00E-32 GO:0007390; GO:0016021; GO:0015101; GO:0030307; GO:0040018 germ-band shortening; integral to membrane; organic cation transmembrane transporter activity; positive regulation of cell growth; positive regulation of multicellular organism growth IPR020846; IPR016196; IPR005828; Organic cation transporter-like protein Orct2 CG13610 Drosophila melanogaster (Fruit fly) TR42806_c3_g1_i8 Q6NUB3 S22AF_XENLA 1.00E-31 GO:0016021; GO:0006811; GO:0022857 integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Solute carrier family 22 member 15 slc22a15 Xenopus laevis (African clawed frog) TR42806_c3_g2_i2 Q95R48 OCTL_DROME 8.00E-44 GO:0007390; GO:0016021; GO:0015101; GO:0030307; GO:0040018 germ-band shortening; integral to membrane; organic cation transmembrane transporter activity; positive regulation of cell growth; positive regulation of multicellular organism growth IPR020846; IPR016196; IPR005828; Organic cation transporter-like protein Orct2 CG13610 Drosophila melanogaster (Fruit fly) TR42806_c3_g2_i4 Q9VCA2 ORCT_DROME 1.00E-52 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR42807_c1_g1_i2 Q9D1Q1 MPH6_MOUSE 7.00E-36 GO:0003723; GO:0005737; GO:0000178; GO:0000460; GO:0005730 RNA binding; cytoplasm; exosome (RNase complex); maturation of 5.8S rRNA; nucleolus IPR019324; M-phase phosphoprotein 6 Mphosph6 Mus musculus (Mouse) TR42808_c0_g2_i3 Q9QXN1 LEF1_RAT 9.00E-46 GO:0042100; GO:0030509; GO:0008301; GO:0003705; GO:0046632; GO:0060561; GO:0070016; GO:0008013; GO:0060070; GO:0060710; GO:0003682; GO:0005737; GO:0021542; GO:0030326; GO:0035326; GO:0001837; GO:0030331; GO:0048069; GO:0060325; GO:0021873; GO:0021879; GO:0021861; GO:0021943; GO:0045295; GO:0021854; GO:0001822; GO:0030879; GO:0048747; GO:0071866; GO:0043154; GO:0032696; GO:0032713; GO:0032714; GO:0001755; GO:0030223; GO:0005634; GO:0071895; GO:0031100; GO:0001649; GO:0048341; GO:0001569; GO:0071864; GO:0022407; GO:0016202; GO:0010226; GO:0014070; GO:0043565; GO:0043588; GO:0001756; GO:0002040; GO:0061153; GO:0005667 "B cell proliferation; BMP signaling pathway; DNA binding, bending; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; alpha-beta T cell differentiation; apoptotic process involved in morphogenesis; armadillo repeat domain binding; beta-catenin binding; canonical Wnt receptor signaling pathway; chorio-allantoic fusion; chromatin binding; cytoplasm; dentate gyrus development; embryonic limb morphogenesis; enhancer binding; epithelial to mesenchymal transition; estrogen receptor binding; eye pigmentation; face morphogenesis; forebrain neuroblast division; forebrain neuron differentiation; forebrain radial glial cell differentiation; formation of radial glial scaffolds; gamma-catenin binding; hypothalamus development; kidney development; mammary gland development; muscle fiber development; negative regulation of apoptotic process in bone marrow; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of interleukin-13 production; negative regulation of interleukin-4 production; negative regulation of interleukin-5 production; neural crest cell migration; neutrophil differentiation; nucleus; odontoblast differentiation; organ regeneration; osteoblast differentiation; paraxial mesoderm formation; patterning of blood vessels; positive regulation of cell proliferation in bone marrow; regulation of cell-cell adhesion; regulation of striated muscle tissue development; response to lithium ion; response to organic cyclic compound; sequence-specific DNA binding; skin development; somitogenesis; sprouting angiogenesis; trachea gland development; transcription factor complex" IPR027397; IPR013558; IPR009071; IPR024940; Lymphoid enhancer-binding factor 1 (LEF-1) Lef1 Rattus norvegicus (Rat) TR42808_c0_g2_i4 P91943 PANG1_DROME 9.00E-52 GO:0003705; GO:0008013; GO:0060070; GO:0009880; GO:0007507; GO:0007476; GO:0007500; GO:0005875; GO:0030178; GO:0045892; GO:0005634; GO:0045944; GO:0045610; GO:0072091; GO:0007435; GO:0007367; GO:0043565; GO:0035277; GO:0005667; GO:0044212 P18824; Q9W0N9; P16371 "RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; beta-catenin binding; canonical Wnt receptor signaling pathway; embryonic pattern specification; heart development; imaginal disc-derived wing morphogenesis; mesodermal cell fate determination; microtubule associated complex; negative regulation of Wnt receptor signaling pathway; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of hemocyte differentiation; regulation of stem cell proliferation; salivary gland morphogenesis; segment polarity determination; sequence-specific DNA binding; spiracle morphogenesis, open tracheal system; transcription factor complex; transcription regulatory region DNA binding" IPR027397; IPR013558; IPR009071; IPR024940; "Protein pangolin, isoforms A/H/I/S (dTCF)" pan TCF CG34403 Drosophila melanogaster (Fruit fly) TR42808_c0_g2_i5 P91943 PANG1_DROME 5.00E-52 GO:0003705; GO:0008013; GO:0060070; GO:0009880; GO:0007507; GO:0007476; GO:0007500; GO:0005875; GO:0030178; GO:0045892; GO:0005634; GO:0045944; GO:0045610; GO:0072091; GO:0007435; GO:0007367; GO:0043565; GO:0035277; GO:0005667; GO:0044212 P18824; Q9W0N9; P16371 "RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; beta-catenin binding; canonical Wnt receptor signaling pathway; embryonic pattern specification; heart development; imaginal disc-derived wing morphogenesis; mesodermal cell fate determination; microtubule associated complex; negative regulation of Wnt receptor signaling pathway; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of hemocyte differentiation; regulation of stem cell proliferation; salivary gland morphogenesis; segment polarity determination; sequence-specific DNA binding; spiracle morphogenesis, open tracheal system; transcription factor complex; transcription regulatory region DNA binding" IPR027397; IPR013558; IPR009071; IPR024940; "Protein pangolin, isoforms A/H/I/S (dTCF)" pan TCF CG34403 Drosophila melanogaster (Fruit fly) TR42809_c0_g3_i3 Q3UTH8 ARHG9_MOUSE 1.00E-35 GO:0005089; GO:0005938; GO:0005085; GO:0005543; GO:0035023; GO:0007264 Rho guanyl-nucleotide exchange factor activity; cell cortex; guanyl-nucleotide exchange factor activity; phospholipid binding; regulation of Rho protein signal transduction; small GTPase mediated signal transduction IPR000219; IPR011993; IPR001849; IPR001452; Rho guanine nucleotide exchange factor 9 (Collybistin) (Rac/Cdc42 guanine nucleotide exchange factor 9) Arhgef9 Kiaa0424 Mus musculus (Mouse) TR42809_c0_g3_i4 Q9ULL1 PKHG1_HUMAN 7.00E-104 GO:0005089; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; phospholipid binding; regulation of Rho protein signal transduction IPR000219; IPR011993; IPR001849; Pleckstrin homology domain-containing family G member 1 PLEKHG1 KIAA1209 Homo sapiens (Human) TR42809_c0_g3_i5 Q63406 MCF2L_RAT 2.00E-31 GO:0005089; GO:0005737; GO:0035556; GO:0005543; GO:0005886; GO:0035023 Rho guanyl-nucleotide exchange factor activity; cytoplasm; intracellular signal transduction; phospholipid binding; plasma membrane; regulation of Rho protein signal transduction IPR001251; IPR000219; IPR001331; IPR011993; IPR001849; IPR001452; IPR018159; IPR002017; Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein) (OST oncogene) Mcf2l Ost Rattus norvegicus (Rat) TR42809_c0_g3_i7 Q9NHV9 VAV_DROME 2.00E-20 GO:0030676; GO:0031532; GO:0007015; GO:0032863; GO:0007155; GO:0016477; GO:0007417; GO:0007391; GO:0035556; GO:0035011; GO:0046872; GO:0007520; GO:0007424; GO:0005543; GO:0072499; GO:0008360 Rac guanyl-nucleotide exchange factor activity; actin cytoskeleton reorganization; actin filament organization; activation of Rac GTPase activity; cell adhesion; cell migration; central nervous system development; dorsal closure; intracellular signal transduction; melanotic encapsulation of foreign target; metal ion binding; myoblast fusion; open tracheal system development; phospholipid binding; photoreceptor cell axon guidance; regulation of cell shape IPR001715; IPR000219; IPR011993; IPR001849; IPR002219; IPR000980; IPR001452; Protein vav (DroVav) (dVAV) Vav CG7893 Drosophila melanogaster (Fruit fly) TR42809_c0_g3_i8 Q9ULL1 PKHG1_HUMAN 8.00E-77 GO:0005089; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; phospholipid binding; regulation of Rho protein signal transduction IPR000219; IPR011993; IPR001849; Pleckstrin homology domain-containing family G member 1 PLEKHG1 KIAA1209 Homo sapiens (Human) TR42810_c1_g1_i1 Q07192 MP2K2_XENLA 3.00E-111 GO:0005524; GO:0018108; GO:0004674; GO:0004713 ATP binding; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (MAPK-ERK kinase 2) (Fragment) map2k2 mek2 Xenopus laevis (African clawed frog) TR42810_c1_g1_i3 P52564 MP2K6_HUMAN 4.00E-146 GO:0005524; GO:0006975; GO:0004708; GO:0002755; GO:0035666; GO:0006915; GO:0060048; GO:0007050; GO:0005856; GO:0005829; GO:0045087; GO:0042692; GO:0005654; GO:0070423; GO:0018108; GO:0043065; GO:0051149; GO:0004674; GO:0004713; GO:0006355; GO:0042493; GO:0051403; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124; GO:0006351 Q5S007 "ATP binding; DNA damage induced protein phosphorylation; MAP kinase kinase activity; MyD88-dependent toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; apoptotic process; cardiac muscle contraction; cell cycle arrest; cytoskeleton; cytosol; innate immune response; muscle cell differentiation; nucleoplasm; nucleotide-binding oligomerization domain containing signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of apoptotic process; positive regulation of muscle cell differentiation; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of transcription, DNA-dependent; response to drug; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor TLR1:TLR2 signaling pathway; toll-like receptor TLR6:TLR2 signaling pathway; transcription, DNA-dependent" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3) MAP2K6 MEK6 MKK6 PRKMK6 SKK3 Homo sapiens (Human) TR42810_c1_g1_i4 Q9DGE0 MP2K6_DANRE 8.00E-140 GO:0005524; GO:0005737; GO:0005856; GO:0005634; GO:0004674; GO:0006355; GO:0006950; GO:0006351 "ATP binding; cytoplasm; cytoskeleton; nucleus; protein serine/threonine kinase activity; regulation of transcription, DNA-dependent; response to stress; transcription, DNA-dependent" IPR011009; IPR000719; IPR002290; IPR008271; Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (Mitogen-activated protein kinase kinase 3) (zMKK3) map2k6 map2k3 Danio rerio (Zebrafish) (Brachydanio rerio) TR42810_c1_g1_i5 Q9JJX8 ST32B_MOUSE 2.00E-20 GO:0005524; GO:0046872; GO:0004674 ATP binding; metal ion binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase 32B (EC 2.7.11.1) Stk32b Stk32 Mus musculus (Mouse) TR42810_c1_g1_i6 Q91447 MP2K1_SERCA 7.00E-61 GO:0005524; GO:0005737; GO:0005634; GO:0018108; GO:0004674; GO:0004713; GO:0005816 ATP binding; cytoplasm; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; spindle pole body IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) (Fragment) MAP2K1 MEK1 PRKMK1 Serinus canaria (Island canary) (Fringilla canaria) TR42810_c1_g1_i7 P52564 MP2K6_HUMAN 7.00E-138 GO:0005524; GO:0006975; GO:0004708; GO:0002755; GO:0035666; GO:0006915; GO:0060048; GO:0007050; GO:0005856; GO:0005829; GO:0045087; GO:0042692; GO:0005654; GO:0070423; GO:0018108; GO:0043065; GO:0051149; GO:0004674; GO:0004713; GO:0006355; GO:0042493; GO:0051403; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124; GO:0006351 Q5S007 "ATP binding; DNA damage induced protein phosphorylation; MAP kinase kinase activity; MyD88-dependent toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; apoptotic process; cardiac muscle contraction; cell cycle arrest; cytoskeleton; cytosol; innate immune response; muscle cell differentiation; nucleoplasm; nucleotide-binding oligomerization domain containing signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of apoptotic process; positive regulation of muscle cell differentiation; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of transcription, DNA-dependent; response to drug; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor TLR1:TLR2 signaling pathway; toll-like receptor TLR6:TLR2 signaling pathway; transcription, DNA-dependent" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3) MAP2K6 MEK6 MKK6 PRKMK6 SKK3 Homo sapiens (Human) TR42810_c1_g1_i8 Q91447 MP2K1_SERCA 1.00E-62 GO:0005524; GO:0005737; GO:0005634; GO:0018108; GO:0004674; GO:0004713; GO:0005816 ATP binding; cytoplasm; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; spindle pole body IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) (Fragment) MAP2K1 MEK1 PRKMK1 Serinus canaria (Island canary) (Fringilla canaria) TR42810_c1_g1_i9 P52564 MP2K6_HUMAN 2.00E-141 GO:0005524; GO:0006975; GO:0004708; GO:0002755; GO:0035666; GO:0006915; GO:0060048; GO:0007050; GO:0005856; GO:0005829; GO:0045087; GO:0042692; GO:0005654; GO:0070423; GO:0018108; GO:0043065; GO:0051149; GO:0004674; GO:0004713; GO:0006355; GO:0042493; GO:0051403; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124; GO:0006351 Q5S007 "ATP binding; DNA damage induced protein phosphorylation; MAP kinase kinase activity; MyD88-dependent toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; apoptotic process; cardiac muscle contraction; cell cycle arrest; cytoskeleton; cytosol; innate immune response; muscle cell differentiation; nucleoplasm; nucleotide-binding oligomerization domain containing signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of apoptotic process; positive regulation of muscle cell differentiation; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of transcription, DNA-dependent; response to drug; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor TLR1:TLR2 signaling pathway; toll-like receptor TLR6:TLR2 signaling pathway; transcription, DNA-dependent" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3) MAP2K6 MEK6 MKK6 PRKMK6 SKK3 Homo sapiens (Human) TR42811_c2_g1_i1 Q16254 E2F4_HUMAN 3.00E-85 GO:0003677; GO:0008015; GO:0006884; GO:0042384; GO:0002064; GO:0000278; GO:0005654; GO:0009887; GO:0045944; GO:0042127; GO:0008361; GO:0000083; GO:0003700; GO:0005667; GO:0006367; GO:0007179 Q5TKA1 DNA binding; blood circulation; cell volume homeostasis; cilium assembly; epithelial cell development; mitotic cell cycle; nucleoplasm; organ morphogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of cell size; regulation of transcription involved in G1/S transition of mitotic cell cycle; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway IPR015633; IPR028312; IPR003316; IPR011991; Transcription factor E2F4 (E2F-4) E2F4 Homo sapiens (Human) TR42811_c2_g1_i3 Q15329 E2F5_HUMAN 1.00E-99 GO:0003677; GO:0005737; GO:0000278; GO:0005654; GO:0009887; GO:0045944; GO:0051726; GO:0003700; GO:0005667; GO:0006367; GO:0007179 DNA binding; cytoplasm; mitotic cell cycle; nucleoplasm; organ morphogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of cell cycle; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway IPR015633; IPR028316; IPR003316; IPR011991; Transcription factor E2F5 (E2F-5) E2F5 Homo sapiens (Human) TR42811_c2_g1_i5 Q16254 E2F4_HUMAN 3.00E-85 GO:0003677; GO:0008015; GO:0006884; GO:0042384; GO:0002064; GO:0000278; GO:0005654; GO:0009887; GO:0045944; GO:0042127; GO:0008361; GO:0000083; GO:0003700; GO:0005667; GO:0006367; GO:0007179 Q5TKA1 DNA binding; blood circulation; cell volume homeostasis; cilium assembly; epithelial cell development; mitotic cell cycle; nucleoplasm; organ morphogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of cell size; regulation of transcription involved in G1/S transition of mitotic cell cycle; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway IPR015633; IPR028312; IPR003316; IPR011991; Transcription factor E2F4 (E2F-4) E2F4 Homo sapiens (Human) TR42811_c2_g1_i6 Q15329 E2F5_HUMAN 8.00E-101 GO:0003677; GO:0005737; GO:0000278; GO:0005654; GO:0009887; GO:0045944; GO:0051726; GO:0003700; GO:0005667; GO:0006367; GO:0007179 DNA binding; cytoplasm; mitotic cell cycle; nucleoplasm; organ morphogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of cell cycle; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway IPR015633; IPR028316; IPR003316; IPR011991; Transcription factor E2F5 (E2F-5) E2F5 Homo sapiens (Human) TR42812_c1_g1_i1 P25153 UBCD6_DROME 4.00E-78 GO:0005524; GO:0006281; GO:0051299; GO:0005737; GO:0007052; GO:0043518; GO:1902166; GO:0005634; GO:0032436; GO:0042787; GO:0004842 "ATP binding; DNA repair; centrosome separation; cytoplasm; mitotic spindle organization; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; nucleus; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity" IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2-17 kDa (EC 6.3.2.19) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) UbcD6 Dhr6 CG2013 Drosophila melanogaster (Fruit fly) TR42812_c1_g1_i2 Q11076 UBC17_CAEEL 4.00E-08 GO:0016881 acid-amino acid ligase activity IPR000608; IPR016135; Probable ubiquitin-conjugating enzyme protein 17 ubc-17 B0403.2 Caenorhabditis elegans TR42812_c1_g1_i3 Q02159 UBC7_YEAST 1.00E-27 GO:0005524; GO:0030433; GO:0006333; GO:0005789; GO:0031505; GO:0046686; GO:0004842 ATP binding; ER-associated protein catabolic process; chromatin assembly or disassembly; endoplasmic reticulum membrane; fungal-type cell wall organization; response to cadmium ion; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 7 (EC 6.3.2.19) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-18 kDa) (Ubiquitin-protein ligase) UBC7 QRI8 YMR022W YM9711.12 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42812_c1_g1_i4 P34477 UBC7_CAEEL 3.00E-24 GO:0005524; GO:0004842 ATP binding; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Probable ubiquitin-conjugating enzyme E2 7 (EC 6.3.2.19) (Ubiquitin carrier protein 7) (Ubiquitin-protein ligase 7) ubc-7 F58A4.10 Caenorhabditis elegans TR42812_c1_g1_i5 P25153 UBCD6_DROME 2.00E-79 GO:0005524; GO:0006281; GO:0051299; GO:0005737; GO:0007052; GO:0043518; GO:1902166; GO:0005634; GO:0032436; GO:0042787; GO:0004842 "ATP binding; DNA repair; centrosome separation; cytoplasm; mitotic spindle organization; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; nucleus; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity" IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2-17 kDa (EC 6.3.2.19) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) UbcD6 Dhr6 CG2013 Drosophila melanogaster (Fruit fly) TR42812_c1_g1_i6 Q02159 UBC7_YEAST 4.00E-29 GO:0005524; GO:0030433; GO:0006333; GO:0005789; GO:0031505; GO:0046686; GO:0004842 ATP binding; ER-associated protein catabolic process; chromatin assembly or disassembly; endoplasmic reticulum membrane; fungal-type cell wall organization; response to cadmium ion; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 7 (EC 6.3.2.19) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-18 kDa) (Ubiquitin-protein ligase) UBC7 QRI8 YMR022W YM9711.12 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42812_c1_g1_i7 P25153 UBCD6_DROME 9.00E-78 GO:0005524; GO:0006281; GO:0051299; GO:0005737; GO:0007052; GO:0043518; GO:1902166; GO:0005634; GO:0032436; GO:0042787; GO:0004842 "ATP binding; DNA repair; centrosome separation; cytoplasm; mitotic spindle organization; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; nucleus; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity" IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2-17 kDa (EC 6.3.2.19) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) UbcD6 Dhr6 CG2013 Drosophila melanogaster (Fruit fly) TR42812_c1_g1_i8 P42747 UBC14_ARATH 3.00E-21 GO:0005524; GO:0004842 ATP binding; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Ubiquitin-conjugating enzyme E2 14 (EC 6.3.2.19) (TAYO29) (UbcAt3) (Ubiquitin carrier protein 14) (Ubiquitin-protein ligase 14) UBC14 UBC3 UBC7 At3g55380 T22E16.40 Arabidopsis thaliana (Mouse-ear cress) TR42812_c1_g1_i9 P34477 UBC7_CAEEL 1.00E-22 GO:0005524; GO:0004842 ATP binding; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. Probable ubiquitin-conjugating enzyme E2 7 (EC 6.3.2.19) (Ubiquitin carrier protein 7) (Ubiquitin-protein ligase 7) ubc-7 F58A4.10 Caenorhabditis elegans TR42813_c1_g1_i10 P70206 PLXA1_MOUSE 9.00E-45 GO:0060666; GO:0016021; GO:0005622; GO:0005886; GO:0014910; GO:0017154 dichotomous subdivision of terminal units involved in salivary gland branching; integral to membrane; intracellular; plasma membrane; regulation of smooth muscle cell migration; semaphorin receptor activity IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A1 (Plex 1) (Plexin-1) Plxna1 Kiaa4053 Mus musculus (Mouse) TR42813_c1_g1_i11 O45657 PLX2_CAEEL 2.00E-12 GO:0030154; GO:0031252; GO:0009986; GO:0009792; GO:0016021; GO:0005622; GO:0002119; GO:0005886; GO:0004872; GO:0007165; GO:0045138 cell differentiation; cell leading edge; cell surface; embryo development ending in birth or egg hatching; integral to membrane; intracellular; nematode larval development; plasma membrane; receptor activity; signal transduction; tail tip morphogenesis IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-2 plx-2 K04B12.1 Caenorhabditis elegans TR42813_c1_g1_i16 P70206 PLXA1_MOUSE 1.00E-44 GO:0060666; GO:0016021; GO:0005622; GO:0005886; GO:0014910; GO:0017154 dichotomous subdivision of terminal units involved in salivary gland branching; integral to membrane; intracellular; plasma membrane; regulation of smooth muscle cell migration; semaphorin receptor activity IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A1 (Plex 1) (Plexin-1) Plxna1 Kiaa4053 Mus musculus (Mouse) TR42813_c1_g1_i17 Q9HCM2 PLXA4_HUMAN 2.00E-42 GO:0021960; GO:0007411; GO:0021793; GO:0021610; GO:0021615; GO:0016021; GO:0005622; GO:0005886; GO:0021784; GO:0048841; GO:0050923; GO:0017154; GO:0002116; GO:0071526; GO:0048485; GO:0021636; GO:0021644 anterior commissure morphogenesis; axon guidance; chemorepulsion of branchiomotor axon; facial nerve morphogenesis; glossopharyngeal nerve morphogenesis; integral to membrane; intracellular; plasma membrane; postganglionic parasympathetic nervous system development; regulation of axon extension involved in axon guidance; regulation of negative chemotaxis; semaphorin receptor activity; semaphorin receptor complex; semaphorin-plexin signaling pathway; sympathetic nervous system development; trigeminal nerve morphogenesis; vagus nerve morphogenesis IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A4 PLXNA4 KIAA1550 PLXNA4A PLXNA4B UNQ2820/PRO34003 Homo sapiens (Human) TR42813_c1_g1_i4 P70206 PLXA1_MOUSE 9.00E-45 GO:0060666; GO:0016021; GO:0005622; GO:0005886; GO:0014910; GO:0017154 dichotomous subdivision of terminal units involved in salivary gland branching; integral to membrane; intracellular; plasma membrane; regulation of smooth muscle cell migration; semaphorin receptor activity IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A1 (Plex 1) (Plexin-1) Plxna1 Kiaa4053 Mus musculus (Mouse) TR42813_c1_g1_i5 Q9HCM2 PLXA4_HUMAN 2.00E-42 GO:0021960; GO:0007411; GO:0021793; GO:0021610; GO:0021615; GO:0016021; GO:0005622; GO:0005886; GO:0021784; GO:0048841; GO:0050923; GO:0017154; GO:0002116; GO:0071526; GO:0048485; GO:0021636; GO:0021644 anterior commissure morphogenesis; axon guidance; chemorepulsion of branchiomotor axon; facial nerve morphogenesis; glossopharyngeal nerve morphogenesis; integral to membrane; intracellular; plasma membrane; postganglionic parasympathetic nervous system development; regulation of axon extension involved in axon guidance; regulation of negative chemotaxis; semaphorin receptor activity; semaphorin receptor complex; semaphorin-plexin signaling pathway; sympathetic nervous system development; trigeminal nerve morphogenesis; vagus nerve morphogenesis IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A4 PLXNA4 KIAA1550 PLXNA4A PLXNA4B UNQ2820/PRO34003 Homo sapiens (Human) TR42813_c1_g1_i7 Q9HCM2 PLXA4_HUMAN 3.00E-42 GO:0021960; GO:0007411; GO:0021793; GO:0021610; GO:0021615; GO:0016021; GO:0005622; GO:0005886; GO:0021784; GO:0048841; GO:0050923; GO:0017154; GO:0002116; GO:0071526; GO:0048485; GO:0021636; GO:0021644 anterior commissure morphogenesis; axon guidance; chemorepulsion of branchiomotor axon; facial nerve morphogenesis; glossopharyngeal nerve morphogenesis; integral to membrane; intracellular; plasma membrane; postganglionic parasympathetic nervous system development; regulation of axon extension involved in axon guidance; regulation of negative chemotaxis; semaphorin receptor activity; semaphorin receptor complex; semaphorin-plexin signaling pathway; sympathetic nervous system development; trigeminal nerve morphogenesis; vagus nerve morphogenesis IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A4 PLXNA4 KIAA1550 PLXNA4A PLXNA4B UNQ2820/PRO34003 Homo sapiens (Human) TR42813_c1_g1_i9 Q3UH93 PLXD1_MOUSE 9.00E-36 GO:0060666; GO:0043542; GO:0005887; GO:0005622; GO:0001569; GO:0032092; GO:0045765; GO:0030334; GO:0017154; GO:0007416 dichotomous subdivision of terminal units involved in salivary gland branching; endothelial cell migration; integral to plasma membrane; intracellular; patterning of blood vessels; positive regulation of protein binding; regulation of angiogenesis; regulation of cell migration; semaphorin receptor activity; synapse assembly IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-D1 Plxnd1 Mus musculus (Mouse) TR42813_c1_g2_i2 O75051 PLXA2_HUMAN 5.00E-50 GO:0007411; GO:0051642; GO:0021935; GO:0005887; GO:0005622; GO:0060174; GO:0021915; GO:0060037; GO:0030334; GO:0017154; GO:0002116; GO:0001756 P39688 axon guidance; centrosome localization; cerebellar granule cell precursor tangential migration; integral to plasma membrane; intracellular; limb bud formation; neural tube development; pharyngeal system development; regulation of cell migration; semaphorin receptor activity; semaphorin receptor complex; somitogenesis IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A2 (Semaphorin receptor OCT) PLXNA2 KIAA0463 OCT PLXN2 UNQ209/PRO235 Homo sapiens (Human) TR42813_c1_g3_i2 Q626H5 PLX2_CAEBR 1.00E-13 GO:0030154; GO:0016021; GO:0005622; GO:0007275; GO:0005886; GO:0004872; GO:0007165 cell differentiation; integral to membrane; intracellular; multicellular organismal development; plasma membrane; receptor activity; signal transduction IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR008936; IPR001627; IPR015943; Plexin-2 plx-2 CBG00979 Caenorhabditis briggsae TR42814_c0_g1_i1 Q2M2H8 MGAL2_HUMAN 2.00E-68 GO:0030246; GO:0005975; GO:0004553; GO:0016021 "carbohydrate binding; carbohydrate metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; integral to membrane" IPR011013; IPR000322; IPR017853; IPR000519; Putative inactive maltase-glucoamylase-like protein LOC93432 Homo sapiens (Human) TR42814_c0_g2_i1 Q9MYM4 LYAG_BOVIN 4.00E-167 GO:0030246; GO:0005975; GO:0060048; GO:0005765; GO:0032450; GO:0043587; GO:0043181; GO:0055010 carbohydrate binding; carbohydrate metabolic process; cardiac muscle contraction; lysosomal membrane; maltose alpha-glucosidase activity; tongue morphogenesis; vacuolar sequestering; ventricular cardiac muscle tissue morphogenesis IPR011013; IPR000322; IPR025887; IPR017853; IPR000519; IPR017957; Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) GAA Bos taurus (Bovine) TR42814_c0_g2_i5 P70699 LYAG_MOUSE 4.00E-21 GO:0004558; GO:0030246; GO:0060048; GO:0002086; GO:0005980; GO:0003007; GO:0007626; GO:0005765; GO:0005764; GO:0007040; GO:0032450; GO:0046716; GO:0050885; GO:0050884; GO:0002026; GO:0009888; GO:0043587; GO:0043181; GO:0055010 alpha-glucosidase activity; carbohydrate binding; cardiac muscle contraction; diaphragm contraction; glycogen catabolic process; heart morphogenesis; locomotory behavior; lysosomal membrane; lysosome; lysosome organization; maltose alpha-glucosidase activity; muscle cell cellular homeostasis; neuromuscular process controlling balance; neuromuscular process controlling posture; regulation of the force of heart contraction; tissue development; tongue morphogenesis; vacuolar sequestering; ventricular cardiac muscle tissue morphogenesis IPR011013; IPR000322; IPR025887; IPR017853; IPR000519; IPR017957; Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) Gaa Mus musculus (Mouse) TR42815_c2_g3_i1 Q5UQG7 YR818_MIMIV 7.00E-26 GO:0005524; GO:0009190; GO:0016021; GO:0035556; GO:0016849; GO:0004674 ATP binding; cyclic nucleotide biosynthetic process; integral to membrane; intracellular signal transduction; phosphorus-oxygen lyase activity; protein serine/threonine kinase activity IPR001054; IPR011009; IPR024370; IPR000719; IPR017441; IPR001245; IPR002290; IPR008271; Putative serine/threonine-protein kinase/receptor R818 (EC 2.7.11.1) MIMI_R818 Acanthamoeba polyphaga mimivirus (APMV) TR42815_c2_g3_i3 P21709 EPHA1_HUMAN 2.00E-09 GO:0005524; GO:0032862; GO:0001525; GO:0005887; GO:0030336; GO:0006469; GO:0045766; GO:0030335; GO:0008284; GO:0001954; GO:0051496; GO:0046777; GO:0032314; GO:0034446; GO:0005005 ATP binding; activation of Rho GTPase activity; angiogenesis; integral to plasma membrane; negative regulation of cell migration; negative regulation of protein kinase activity; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of stress fiber assembly; protein autophosphorylation; regulation of Rac GTPase activity; substrate adhesion-dependent cell spreading; transmembrane-ephrin receptor activity IPR027936; IPR001090; IPR003961; IPR008979; IPR009030; IPR013783; IPR011009; IPR000719; IPR017441; IPR001660; IPR013761; IPR021129; IPR001245; IPR008266; IPR020635; IPR016257; IPR001426; Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH) EPHA1 EPH EPHT EPHT1 Homo sapiens (Human) TR42815_c2_g3_i4 Q9TZM3 LRK1_CAEEL 6.00E-86 GO:0005524; GO:0005525; GO:0005794; GO:0048846; GO:0034613; GO:0046872; GO:0043025; GO:0004674; GO:0034976; GO:0006979; GO:0007264; GO:0048489 ATP binding; GTP binding; Golgi apparatus; axon extension involved in axon guidance; cellular protein localization; metal ion binding; neuronal cell body; protein serine/threonine kinase activity; response to endoplasmic reticulum stress; response to oxidative stress; small GTPase mediated signal transduction; synaptic vesicle transport IPR002110; IPR020683; IPR011009; IPR001611; IPR003591; IPR013684; IPR027417; IPR000719; IPR020859; IPR017986; "Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) (Leucine-rich repeats, ras-like domain, kinase protein 1) (PARK8-related kinase)" lrk-1 T27C10.6 Caenorhabditis elegans TR42815_c2_g4_i1 Q9TZM3 LRK1_CAEEL 7.00E-08 GO:0005524; GO:0005525; GO:0005794; GO:0048846; GO:0034613; GO:0046872; GO:0043025; GO:0004674; GO:0034976; GO:0006979; GO:0007264; GO:0048489 ATP binding; GTP binding; Golgi apparatus; axon extension involved in axon guidance; cellular protein localization; metal ion binding; neuronal cell body; protein serine/threonine kinase activity; response to endoplasmic reticulum stress; response to oxidative stress; small GTPase mediated signal transduction; synaptic vesicle transport IPR002110; IPR020683; IPR011009; IPR001611; IPR003591; IPR013684; IPR027417; IPR000719; IPR020859; IPR017986; "Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) (Leucine-rich repeats, ras-like domain, kinase protein 1) (PARK8-related kinase)" lrk-1 T27C10.6 Caenorhabditis elegans TR42817_c0_g2_i1 Q568M3 CRLF3_DANRE 5.00E-44 GO:0005737 cytoplasm IPR003961; IPR013783; Cytokine receptor-like factor 3 (Clf-3 protein) crlf3 clf-3 zgc:110212 Danio rerio (Zebrafish) (Brachydanio rerio) TR42818_c1_g2_i2 P51957 NEK4_HUMAN 3.00E-44 GO:0005524; GO:0051301; GO:0046872; GO:0007067; GO:0005634; GO:0004674 ATP binding; cell division; metal ion binding; mitosis; nucleus; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) NEK4 STK2 Homo sapiens (Human) TR42818_c1_g2_i8 P51957 NEK4_HUMAN 2.00E-61 GO:0005524; GO:0051301; GO:0046872; GO:0007067; GO:0005634; GO:0004674 ATP binding; cell division; metal ion binding; mitosis; nucleus; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) NEK4 STK2 Homo sapiens (Human) TR42819_c0_g1_i3 Q5SRX1 TM1L2_MOUSE 3.00E-124 GO:0005622; GO:0006886 intracellular; intracellular protein transport IPR008942; IPR004152; IPR014645; IPR027429; IPR002014; IPR018205; TOM1-like protein 2 (Target of Myb-like protein 2) Tom1l2 Mus musculus (Mouse) TR42819_c0_g1_i4 Q5SRX1 TM1L2_MOUSE 4.00E-124 GO:0005622; GO:0006886 intracellular; intracellular protein transport IPR008942; IPR004152; IPR014645; IPR027429; IPR002014; IPR018205; TOM1-like protein 2 (Target of Myb-like protein 2) Tom1l2 Mus musculus (Mouse) TR42819_c0_g1_i6 O12940 TOM1_CHICK 1.00E-104 GO:0005829; GO:0005769; GO:0006886; GO:0016020 cytosol; early endosome; intracellular protein transport; membrane IPR008942; IPR004152; IPR014645; IPR002014; IPR018205; Target of Myb protein 1 (Tom-1) TOM1 Gallus gallus (Chicken) TR42820_c0_g1_i2 Q5JSZ5 PRC2B_HUMAN 9.00E-20 Q96KQ7; P09022 IPR009738; Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) PRRC2B BAT2L BAT2L1 KIAA0515 Homo sapiens (Human) TR42820_c0_g2_i1 Q3TLH4 PRC2C_MOUSE 1.00E-11 IPR009738; Protein PRRC2C (BAT2 domain-containing protein 1) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Prrc2c Bat2d Bat2d1 Bat2l2 Kiaa1096 Mus musculus (Mouse) TR42822_c1_g1_i1 A0JP75 EFC4A_XENTR 6.00E-50 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; EF-hand calcium-binding domain-containing protein 4A efcab4a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42822_c1_g1_i2 A1A600 EFC4A_DANRE 1.00E-49 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; EF-hand calcium-binding domain-containing protein 4A efcab4a zgc:158448 Danio rerio (Zebrafish) (Brachydanio rerio) TR42823_c1_g1_i3 Q54ZG7 TM234_DICDI 3.00E-31 GO:0016021 integral to membrane IPR018908; Transmembrane protein 234 homolog DDB_G0277575 Dictyostelium discoideum (Slime mold) TR42823_c2_g1_i1 O75970 MPDZ_HUMAN 8.00E-133 GO:0043220; GO:0016324; GO:0016327; GO:0007155; GO:0005737; GO:0031410; GO:0030425; GO:0019048; GO:0042552; GO:0014069; GO:0045211; GO:0005923 Q9H205; Q9HB21; Q9ERS5; P32745; P04637 Schmidt-Lanterman incisure; apical plasma membrane; apicolateral plasma membrane; cell adhesion; cytoplasm; cytoplasmic vesicle; dendrite; modulation by virus of host morphology or physiology; myelination; postsynaptic density; postsynaptic membrane; tight junction IPR004172; IPR015132; IPR001478; Multiple PDZ domain protein (Multi-PDZ domain protein 1) MPDZ MUPP1 Homo sapiens (Human) TR42823_c2_g1_i2 Q9NB04 PATJ_DROME 3.00E-102 GO:0005912; GO:0034334; GO:0045179; GO:0016324; GO:0045176; GO:0016327; GO:0001736; GO:0035088; GO:0016332; GO:0016334; GO:0005875; GO:0032033; GO:0035509; GO:0005635; GO:0045494; GO:0008594; GO:0035209; GO:0005918; GO:0035003; GO:0045186 Q0E974 adherens junction; adherens junction maintenance; apical cortex; apical plasma membrane; apical protein localization; apicolateral plasma membrane; establishment of planar polarity; establishment or maintenance of apical/basal cell polarity; establishment or maintenance of polarity of embryonic epithelium; establishment or maintenance of polarity of follicular epithelium; microtubule associated complex; myosin II light chain binding; negative regulation of myosin-light-chain-phosphatase activity; nuclear envelope; photoreceptor cell maintenance; photoreceptor cell morphogenesis; pupal development; septate junction; subapical complex; zonula adherens assembly IPR004172; IPR001478; Patj homolog Patj CG12021 Drosophila melanogaster (Fruit fly) TR42823_c2_g1_i3 O75970 MPDZ_HUMAN 2.00E-172 GO:0043220; GO:0016324; GO:0016327; GO:0007155; GO:0005737; GO:0031410; GO:0030425; GO:0019048; GO:0042552; GO:0014069; GO:0045211; GO:0005923 Q9H205; Q9HB21; Q9ERS5; P32745; P04637 Schmidt-Lanterman incisure; apical plasma membrane; apicolateral plasma membrane; cell adhesion; cytoplasm; cytoplasmic vesicle; dendrite; modulation by virus of host morphology or physiology; myelination; postsynaptic density; postsynaptic membrane; tight junction IPR004172; IPR015132; IPR001478; Multiple PDZ domain protein (Multi-PDZ domain protein 1) MPDZ MUPP1 Homo sapiens (Human) TR42825_c1_g3_i5 Q09225 NRF6_CAEEL 1.00E-56 GO:0016021; GO:0008289; GO:0006869; GO:0007275; GO:0016747 "integral to membrane; lipid binding; lipid transport; multicellular organismal development; transferase activity, transferring acyl groups other than amino-acyl groups" IPR002656; IPR006621; Nose resistant to fluoxetine protein 6 (Protein nrf-6) nrf-6 C08B11.4 Caenorhabditis elegans TR42826_c1_g2_i2 O62640 PIAP_PIG 8.00E-51 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; IPR013083; Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) TR42826_c1_g2_i4 Q05AK5 MYLIB_DANRE 6.00E-08 GO:0005737; GO:0005856; GO:0005829; GO:0007369; GO:0016874; GO:0030178; GO:0016567; GO:0008270 cytoplasm; cytoskeleton; cytosol; gastrulation; ligase activity; negative regulation of Wnt receptor signaling pathway; protein ubiquitination; zinc ion binding IPR019749; IPR019750; IPR014352; IPR019748; IPR000299; IPR018979; IPR011993; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MYLIP-B (EC 6.3.2.-) (Myosin regulatory light chain-interacting protein B) (MIR-B) mylipb zgc:153767 Danio rerio (Zebrafish) (Brachydanio rerio) TR42826_c1_g2_i6 Q9LY87 RGLG2_ARATH 2.00E-07 GO:0009850; GO:0009690; GO:0080148; GO:0005634; GO:0005886; GO:0004842; GO:0008270 auxin metabolic process; cytokinin metabolic process; negative regulation of response to water deprivation; nucleus; plasma membrane; ubiquitin-protein ligase activity; zinc ion binding IPR010734; IPR002035; IPR001841; IPR013083; E3 ubiquitin-protein ligase RGLG2 (EC 6.3.2.-) (RING domain ligase 2) RGLG2 At5g14420 F18O22.210 Arabidopsis thaliana (Mouse-ear cress) TR42826_c1_g2_i7 Q6TEM9 MYLIA_DANRE 2.00E-08 GO:0005737; GO:0005856; GO:0005829; GO:0007369; GO:0016874; GO:0030178; GO:0016567; GO:0008270 cytoplasm; cytoskeleton; cytosol; gastrulation; ligase activity; negative regulation of Wnt receptor signaling pathway; protein ubiquitination; zinc ion binding IPR019749; IPR019750; IPR014352; IPR019748; IPR000299; IPR018979; IPR011993; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MYLIP-A (EC 6.3.2.-) (Myosin regulatory light chain-interacting protein A) (MIR-A) mylipa mir mylip si:ch211-266j17.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR42827_c1_g1_i2 O14874 BCKD_HUMAN 3.00E-150 GO:0005524; GO:0047323; GO:0009083; GO:0005947; GO:0004674 P40763 ATP binding; [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity; branched-chain amino acid catabolic process; mitochondrial alpha-ketoglutarate dehydrogenase complex; protein serine/threonine kinase activity IPR018955; IPR003594; IPR004358; IPR005467; "[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial (EC 2.7.11.4) (Branched-chain alpha-ketoacid dehydrogenase kinase) (BCKD-kinase) (BCKDHKIN)" BCKDK Homo sapiens (Human) TR42828_c1_g1_i1 Q96MM6 HS12B_HUMAN 2.00E-16 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR42828_c2_g5_i4 O43301 HS12A_HUMAN 8.00E-50 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR42828_c2_g5_i5 O43301 HS12A_HUMAN 5.00E-49 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR42828_c2_g9_i1 B1H009 DNAK_UNCTG 6.00E-07 GO:0005524; GO:0006457; GO:0006950 ATP binding; protein folding; response to stress IPR012725; IPR018181; IPR013126; Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK TGRD_358 Uncultured termite group 1 bacterium phylotype Rs-D17 TR42828_c2_g9_i6 A9IQZ6 HSCA_BORPD 4.00E-06 GO:0005524; GO:0016887; GO:0016226; GO:0006457 ATP binding; ATPase activity; iron-sulfur cluster assembly; protein folding IPR018181; IPR013126; IPR010236; Chaperone protein HscA homolog hscA Bpet2773 Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) TR42830_c1_g2_i3 A1L224 CR3L2_DANRE 1.00E-29 GO:0002062; GO:0005783; GO:0005789; GO:0016021; GO:0005634; GO:0060628; GO:0003330; GO:0034976; GO:0006986; GO:0043565; GO:0003700; GO:0044212; GO:0006351 "chondrocyte differentiation; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nucleus; regulation of ER to Golgi vesicle-mediated transport; regulation of extracellular matrix constituent secretion; response to endoplasmic reticulum stress; response to unfolded protein; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR004827; Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] creb3l2 zgc:158603 Danio rerio (Zebrafish) (Brachydanio rerio) TR42831_c1_g1_i1 P28827 PTPRM_HUMAN 1.00E-153 GO:0045296; GO:0005913; GO:0007156; GO:0005887; GO:0030027; GO:0016525; GO:0010596; GO:0001937; GO:0048471; GO:0045909; GO:0042493; GO:0010842; GO:0031290; GO:0005001 Itself; P09803 cadherin binding; cell-cell adherens junction; homophilic cell adhesion; integral to plasma membrane; lamellipodium; negative regulation of angiogenesis; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; perinuclear region of cytoplasm; positive regulation of vasodilation; response to drug; retina layer formation; retinal ganglion cell axon guidance; transmembrane receptor protein tyrosine phosphatase activity IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR013151; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) TR42831_c1_g1_i2 P18433 PTPRA_HUMAN 3.00E-137 GO:0007411; GO:0008286; GO:0005887; GO:0006468; GO:0005001 P14781; P39688; P62993; P00523; P12931 axon guidance; insulin receptor signaling pathway; integral to plasma membrane; protein phosphorylation; transmembrane receptor protein tyrosine phosphatase activity IPR000387; IPR016130; IPR000242; IPR016336; IPR027262; Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) TR42831_c1_g1_i3 Q06806 TIE1_MOUSE 1.00E-28 GO:0005524; GO:0001525; GO:0001701; GO:0016021; GO:0016525; GO:0030336; GO:0018108; GO:0005886; GO:0045026; GO:0032526; GO:0004714 ATP binding; angiogenesis; in utero embryonic development; integral to membrane; negative regulation of angiogenesis; negative regulation of cell migration; peptidyl-tyrosine phosphorylation; plasma membrane; plasma membrane fusion; response to retinoic acid; transmembrane receptor protein tyrosine kinase activity IPR000742; IPR013032; IPR003961; IPR007110; IPR013783; IPR003599; IPR013151; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) Tie1 Tie Tie-1 Mus musculus (Mouse) TR42831_c1_g1_i4 P06868 PLMN_BOVIN 1.00E-15 GO:0007596; GO:0005576; GO:0042730; GO:0006508; GO:0004252; GO:0048771 blood coagulation; extracellular region; fibrinolysis; proteolysis; serine-type endopeptidase activity; tissue remodeling IPR000001; IPR013806; IPR018056; IPR003014; IPR003609; IPR023317; IPR001254; IPR018114; IPR001314; IPR009003; "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Bos taurus (Bovine) TR42832_c4_g1_i1 O13262 SCNNC_XENLA 3.00E-45 GO:0016324; GO:0016021; GO:0015280; GO:0050896; GO:0050909; GO:0035725 apical plasma membrane; integral to membrane; ligand-gated sodium channel activity; response to stimulus; sensory perception of taste; sodium ion transmembrane transport IPR004724; IPR001873; IPR020903; Amiloride-sensitive sodium channel subunit beta-2 (Beta-2-NaCH) (Epithelial Na(+) channel subunit beta-2) (Beta-2-ENaC) (Nonvoltage-gated sodium channel 1 subunit beta-2) (SCNEB2) scnn1b-b Xenopus laevis (African clawed frog) TR42833_c1_g1_i1 Q05086 UBE3A_HUMAN 0 GO:0030521; GO:0007420; GO:0005737; GO:0005829; GO:0019048; GO:0005634; GO:0001541; GO:0014068; GO:0045944; GO:0060736; GO:0000502; GO:0070936; GO:0042787; GO:0035037; GO:0003713; GO:0004842 P03126; P04019; P06463; P06931; Q77E16; P04637 androgen receptor signaling pathway; brain development; cytoplasm; cytosol; modulation by virus of host morphology or physiology; nucleus; ovarian follicle development; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of transcription from RNA polymerase II promoter; prostate gland growth; proteasome complex; protein K48-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; sperm entry; transcription coactivator activity; ubiquitin-protein ligase activity IPR000569; IPR017134; Protein modification; protein ubiquitination. Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54) UBE3A E6AP EPVE6AP HPVE6A Homo sapiens (Human) TR42833_c1_g1_i2 Q5U5R9 HECD2_HUMAN 3.00E-96 GO:0005737; GO:0005634; GO:0042787; GO:0004842 cytoplasm; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000569; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HECTD2 (EC 6.3.2.-) (HECT domain-containing protein 2) HECTD2 Homo sapiens (Human) TR42833_c1_g1_i3 Q6PAV2 HERC4_MOUSE 9.00E-88 GO:0030154; GO:0005737; GO:0005829; GO:0005634; GO:0042787; GO:0007283; GO:0004842 cell differentiation; cytoplasm; cytosol; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; spermatogenesis; ubiquitin-protein ligase activity IPR000569; IPR009091; IPR000408; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase HERC4 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 4) Herc4 Mus musculus (Mouse) TR42834_c1_g2_i2 O14924 RGS12_HUMAN 4.00E-32 GO:0005096; GO:0000794; GO:0005737; GO:0016363; GO:0005886; GO:0005057; GO:0008277; GO:0038032; GO:0006351 "GTPase activator activity; condensed nuclear chromosome; cytoplasm; nuclear matrix; plasma membrane; receptor signaling protein activity; regulation of G-protein coupled receptor protein signaling pathway; termination of G-protein coupled receptor signaling pathway; transcription, DNA-dependent" IPR003109; IPR001478; IPR011993; IPR006020; IPR003116; IPR024066; IPR016137; IPR000342; Regulator of G-protein signaling 12 (RGS12) RGS12 Homo sapiens (Human) TR42834_c1_g2_i4 Q9VCX1 RGS_DROME 8.00E-28 GO:0007186; GO:0005092; GO:0005096; GO:0045179; GO:0016324; GO:0055059; GO:0008105; GO:0032291; GO:0007049; GO:0030866; GO:0007303; GO:0050832; GO:0008069; GO:0000578; GO:0014045; GO:0060857; GO:0003015; GO:0007310; GO:0005886; GO:0005057; GO:0008277; GO:0009786; GO:0009408; GO:0006979; GO:0042594; GO:0019991; GO:0038032; GO:0007419 "G-protein coupled receptor signaling pathway; GDP-dissociation inhibitor activity; GTPase activator activity; apical cortex; apical plasma membrane; asymmetric neuroblast division; asymmetric protein localization; axon ensheathment in central nervous system; cell cycle; cortical actin cytoskeleton organization; cytoplasmic transport, nurse cell to oocyte; defense response to fungus; dorsal/ventral axis specification, ovarian follicular epithelium; embryonic axis specification; establishment of endothelial blood-brain barrier; establishment of glial blood-brain barrier; heart process; oocyte dorsal/ventral axis specification; plasma membrane; receptor signaling protein activity; regulation of G-protein coupled receptor protein signaling pathway; regulation of asymmetric cell division; response to heat; response to oxidative stress; response to starvation; septate junction assembly; termination of G-protein coupled receptor signaling pathway; ventral cord development" IPR003109; IPR001478; IPR011993; IPR006020; IPR003116; IPR024066; IPR016137; IPR000342; Regulator of G-protein signaling loco (RGS) (Locomotion defects protein) (Loco) loco CG5248 Drosophila melanogaster (Fruit fly) TR42834_c1_g3_i1 P41228 KDM5C_CRIGR 4.00E-18 GO:0016568; GO:0051213; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "chromatin modification; dioxygenase activity; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR013083 Lysine-specific demethylase 5C (EC 1.14.11.-) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) (Fragment) KDM5C JARID1C SMCX XE169 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR42834_c1_g4_i1 Q3UXZ9 KDM5A_MOUSE 0 GO:0003677; GO:0003682; GO:0016568; GO:0019907; GO:0005737; GO:0007275; GO:0005730; GO:0016706; GO:0045893; GO:0006351; GO:0008270 Q80U70 "DNA binding; chromatin binding; chromatin modification; cyclin-dependent protein kinase activating kinase holoenzyme complex; cytoplasm; multicellular organismal development; nucleolus; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001606; IPR003347; IPR013637; IPR003349; IPR019786; IPR004198; IPR011011; IPR001965; IPR019787; IPR013083; Lysine-specific demethylase 5A (EC 1.14.11.-) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) Kdm5a Jarid1a Rbp2 Mus musculus (Mouse) TR42834_c1_g4_i2 Q3UXZ9 KDM5A_MOUSE 0 GO:0003677; GO:0003682; GO:0016568; GO:0019907; GO:0005737; GO:0007275; GO:0005730; GO:0016706; GO:0045893; GO:0006351; GO:0008270 Q80U70 "DNA binding; chromatin binding; chromatin modification; cyclin-dependent protein kinase activating kinase holoenzyme complex; cytoplasm; multicellular organismal development; nucleolus; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001606; IPR003347; IPR013637; IPR003349; IPR019786; IPR004198; IPR011011; IPR001965; IPR019787; IPR013083; Lysine-specific demethylase 5A (EC 1.14.11.-) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) Kdm5a Jarid1a Rbp2 Mus musculus (Mouse) TR42835_c0_g1_i2 Q6IMZ0 NFIL3_RAT 2.00E-20 GO:0001078; GO:0000979; GO:0071353; GO:0007623; GO:0005634; GO:0010628; GO:0003700 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II core promoter sequence-specific DNA binding; cellular response to interleukin-4; circadian rhythm; nucleus; positive regulation of gene expression; sequence-specific DNA binding transcription factor activity IPR004827; IPR016743; IPR010533; Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) Nfil3 Rattus norvegicus (Rat) TR42837_c1_g1_i1 Q04637 IF4G1_HUMAN 1.00E-105 GO:0008219; GO:0019221; GO:0005829; GO:0016281; GO:0008286; GO:0019048; GO:0000184; GO:0000289; GO:0006446; GO:0003743 O00571; O75822; P60842; P06730; Q14103-4; P11940 "cell death; cytokine-mediated signaling pathway; cytosol; eukaryotic translation initiation factor 4F complex; insulin receptor signaling pathway; modulation by virus of host morphology or physiology; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nuclear-transcribed mRNA poly(A) tail shortening; regulation of translational initiation; translation initiation factor activity" IPR016024; IPR003891; IPR016021; IPR003890; IPR003307; Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) EIF4G1 EIF4F EIF4G EIF4GI Homo sapiens (Human) TR42837_c1_g1_i2 Q03387 IF41_WHEAT 6.00E-41 GO:0006417; GO:0003743 regulation of translation; translation initiation factor activity IPR016024; IPR003891; IPR016021; IPR003890; Eukaryotic translation initiation factor isoform 4G-1 (eIF(iso)-4G-1) (eIF(iso)4G-1) (Eukaryotic initiation factor iso-4F subunit p82-34) (eIF-(iso)4F p82-34 subunit) Triticum aestivum (Wheat) TR42837_c1_g1_i4 O43432 IF4G3_HUMAN 7.00E-126 GO:0000339; GO:0019221; GO:0005829; GO:0016281; GO:0019048; GO:0006446; GO:0008135; GO:0003743 "RNA cap binding; cytokine-mediated signaling pathway; cytosol; eukaryotic translation initiation factor 4F complex; modulation by virus of host morphology or physiology; regulation of translational initiation; translation factor activity, nucleic acid binding; translation initiation factor activity" IPR016024; IPR003891; IPR016021; IPR003890; IPR003307; Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) EIF4G3 Homo sapiens (Human) TR42838_c1_g1_i3 Q9P2J5 SYLC_HUMAN 0 GO:0005524; GO:0002161; GO:0005829; GO:0004823; GO:0006429; GO:0006450; GO:0006418 P54136; Q8N122; Q9NQL2 ATP binding; aminoacyl-tRNA editing activity; cytosol; leucine-tRNA ligase activity; leucyl-tRNA aminoacylation; regulation of translational fidelity; tRNA aminoacylation for protein translation IPR001412; IPR002300; IPR004493; IPR014729; IPR009080; IPR013155; IPR009008; "Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)" LARS KIAA1352 Homo sapiens (Human) TR42838_c1_g1_i4 Q8BMJ2 SYLC_MOUSE 0 GO:0005524; GO:0002161; GO:0005737; GO:0004823; GO:0006429; GO:0006450 ATP binding; aminoacyl-tRNA editing activity; cytoplasm; leucine-tRNA ligase activity; leucyl-tRNA aminoacylation; regulation of translational fidelity IPR001412; IPR002300; IPR004493; IPR014729; IPR009080; IPR013155; IPR009008; "Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)" Lars Mus musculus (Mouse) TR42839_c1_g3_i1 A2RSY1 KANL3_MOUSE 0 GO:0043984; GO:0043981; GO:0043982; GO:0000123 histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase complex IPR026555; KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) Kansl3 Kiaa1310 Nsl3 Mus musculus (Mouse) TR42839_c1_g3_i4 A2RSY1 KANL3_MOUSE 2.00E-179 GO:0043984; GO:0043981; GO:0043982; GO:0000123 histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase complex IPR026555; KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) Kansl3 Kiaa1310 Nsl3 Mus musculus (Mouse) TR4284_c0_g1_i1 P10632 CP2C8_HUMAN 1.00E-13 GO:0070330; GO:0034875; GO:0005789; GO:0019373; GO:0042738; GO:0020037; GO:0005506; GO:0004497; GO:0097267; GO:0070989; GO:0006805 aromatase activity; caffeine oxidase activity; endoplasmic reticulum membrane; epoxygenase P450 pathway; exogenous drug catabolic process; heme binding; iron ion binding; monooxygenase activity; omega-hydroxylase P450 pathway; oxidative demethylation; xenobiotic metabolic process IPR001128; IPR017972; IPR002401; Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase) CYP2C8 Homo sapiens (Human) TR4284_c0_g2_i1 Q92088 CP2M1_ONCMY 8.00E-11 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 2M1 (EC 1.14.14.1) (CYPIIM1) (LMC1) (Lauric acid omega-6-hydroxylase) cyp2m1 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR42840_c1_g2_i4 Q32NW2 LENG8_XENLA 6.00E-70 IPR005062; Leukocyte receptor cluster member 8 homolog leng8 Xenopus laevis (African clawed frog) TR42841_c1_g1_i1 Q8N6D5 ANR29_HUMAN 1.00E-09 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 29 ANKRD29 Homo sapiens (Human) TR42842_c1_g1_i4 Q9BYW2 SETD2_HUMAN 4.00E-35 GO:0001525; GO:0035441; GO:0005694; GO:0060977; GO:0048701; GO:0060669; GO:0030900; GO:0097198; GO:0018024; GO:0048332; GO:0006298; GO:0001763; GO:0001843; GO:0034728; GO:0005634; GO:0060039; GO:0010793; GO:0006355; GO:0048864; GO:0006368 P84022 "angiogenesis; cell migration involved in vasculogenesis; chromosome; coronary vasculature morphogenesis; embryonic cranial skeleton morphogenesis; embryonic placenta morphogenesis; forebrain development; histone H3-K36 trimethylation; histone-lysine N-methyltransferase activity; mesoderm morphogenesis; mismatch repair; morphogenesis of a branching structure; neural tube closure; nucleosome organization; nucleus; pericardium development; regulation of mRNA export from nucleus; regulation of transcription, DNA-dependent; stem cell development; transcription elongation from RNA polymerase II promoter" IPR006560; IPR003616; IPR001214; IPR013257; IPR001202; Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.43) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (SET domain-containing protein 2) (hSET2) (p231HBP) SETD2 HIF1 HYPB KIAA1732 KMT3A SET2 HSPC069 Homo sapiens (Human) TR42844_c0_g2_i1 Q0P5W1 VPS8_MOUSE 0 GO:0008270 zinc ion binding IPR025941; IPR015943; IPR001680; IPR017986; IPR001841; IPR013083; Vacuolar protein sorting-associated protein 8 homolog Vps8 Kiaa0804 Mus musculus (Mouse) TR42844_c0_g3_i1 Q8N3P4 VPS8_HUMAN 0 GO:0008270 zinc ion binding IPR011044; IPR025941; IPR015943; IPR001680; IPR017986; IPR001841; IPR013083; Vacuolar protein sorting-associated protein 8 homolog VPS8 KIAA0804 Homo sapiens (Human) TR42844_c0_g3_i3 Q0P5W1 VPS8_MOUSE 3.00E-63 GO:0008270 zinc ion binding IPR025941; IPR015943; IPR001680; IPR017986; IPR001841; IPR013083; Vacuolar protein sorting-associated protein 8 homolog Vps8 Kiaa0804 Mus musculus (Mouse) TR42847_c1_g3_i1 Q76LL6 FHOD3_MOUSE 1.00E-107 GO:0030018; GO:0051639; GO:0007015; GO:0005856; GO:0030837; GO:0030017; GO:0045214 Z disc; actin filament network formation; actin filament organization; cytoskeleton; negative regulation of actin filament polymerization; sarcomere; sarcomere organization IPR016024; IPR014767; IPR015425; IPR027651; IPR014768; FH1/FH2 domain-containing protein 3 (Formin homolog overexpressed in spleen 2) (mFHOS2) Fhod3 Fhos2 Kiaa1695 Mus musculus (Mouse) TR42847_c1_g3_i2 Q76LL6 FHOD3_MOUSE 6.00E-113 GO:0030018; GO:0051639; GO:0007015; GO:0005856; GO:0030837; GO:0030017; GO:0045214 Z disc; actin filament network formation; actin filament organization; cytoskeleton; negative regulation of actin filament polymerization; sarcomere; sarcomere organization IPR016024; IPR014767; IPR015425; IPR027651; IPR014768; FH1/FH2 domain-containing protein 3 (Formin homolog overexpressed in spleen 2) (mFHOS2) Fhod3 Fhos2 Kiaa1695 Mus musculus (Mouse) TR42848_c1_g2_i1 P40744 B910_XENLA 4.00E-31 IPR002087; Maternal B9.10 protein (p30 B9.10) Xenopus laevis (African clawed frog) TR42849_c2_g2_i2 Q99650 OSMR_HUMAN 5.00E-06 GO:0008283; GO:0004924; GO:0005900; GO:0002675; GO:0008284 cell proliferation; oncostatin-M receptor activity; oncostatin-M receptor complex; positive regulation of acute inflammatory response; positive regulation of cell proliferation IPR003961; IPR003529; IPR013783; Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB) OSMR OSMRB Homo sapiens (Human) TR42849_c2_g2_i4 O70535 LIFR_RAT 4.00E-07 GO:0019955; GO:0016021; GO:0004923; GO:0010656; GO:0048812; GO:0031100; GO:0005886; GO:0046982 cytokine binding; integral to membrane; leukemia inhibitory factor receptor activity; negative regulation of muscle cell apoptotic process; neuron projection morphogenesis; organ regeneration; plasma membrane; protein heterodimerization activity IPR003961; IPR003529; IPR013783; Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118) Lifr Rattus norvegicus (Rat) TR42851_c1_g1_i3 Q8BR07 BICD1_MOUSE 4.00E-85 GO:0005794; GO:0005881; GO:0031410; GO:0005829; GO:0072517; GO:0016020; GO:0072393; GO:0072385; GO:1900275; GO:1900737; GO:0048471; GO:0048260; GO:0033365; GO:1900276; GO:0034063; GO:0005802; GO:0016032 Golgi apparatus; cytoplasmic microtubule; cytoplasmic vesicle; cytosol; host cell viral assembly compartment; membrane; microtubule anchoring at microtubule organizing center; minus-end-directed organelle transport along microtubule; negative regulation of phospholipase C activity; negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway; perinuclear region of cytoplasm; positive regulation of receptor-mediated endocytosis; protein localization to organelle; regulation of proteinase activated receptor activity; stress granule assembly; trans-Golgi network; viral process IPR018477; Protein bicaudal D homolog 1 (Bic-D 1) Bicd1 Mus musculus (Mouse) TR42853_c0_g1_i3 Q3UHK6 TEN4_MOUSE 5.00E-100 GO:0060912; GO:0060038; GO:0032289; GO:0005737; GO:0001702; GO:0005887; GO:0048666; GO:0043005; GO:0005634; GO:2000543; GO:0031643; GO:0048714; GO:0042803; GO:0007165 cardiac cell fate specification; cardiac muscle cell proliferation; central nervous system myelin formation; cytoplasm; gastrulation with mouth forming second; integral to plasma membrane; neuron development; neuron projection; nucleus; positive regulation of gastrulation; positive regulation of myelination; positive regulation of oligodendrocyte differentiation; protein homodimerization activity; signal transduction IPR011042; IPR008969; IPR000742; IPR013032; IPR013111; IPR022385; IPR027691; IPR009471; IPR006530; Teneurin-4 (Ten-4) (Downstream of CHOP4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4) Tenm4 Doc4 Kiaa1302 Odz4 Tnm4 Mus musculus (Mouse) TR42853_c0_g1_i4 Q9W6V6 TEN1_CHICK 6.00E-74 GO:0005794; GO:0005856; GO:0005783; GO:0005887; GO:0007218; GO:0016363; GO:0016607; GO:0048471; GO:0043406; GO:0030838; GO:0051491; GO:0090316; GO:0033138; GO:0046982; GO:0042803; GO:0006359; GO:0006950; GO:0006351 "Golgi apparatus; cytoskeleton; endoplasmic reticulum; integral to plasma membrane; neuropeptide signaling pathway; nuclear matrix; nuclear speck; perinuclear region of cytoplasm; positive regulation of MAP kinase activity; positive regulation of actin filament polymerization; positive regulation of filopodium assembly; positive regulation of intracellular protein transport; positive regulation of peptidyl-serine phosphorylation; protein heterodimerization activity; protein homodimerization activity; regulation of transcription from RNA polymerase III promoter; response to stress; transcription, DNA-dependent" IPR011042; IPR008969; IPR000742; IPR013032; IPR009471; IPR027688; IPR006530; Teneurin-1 (Ten-1) (Protein Odd Oz/ten-m homolog 1) (Tenascin-M1) (Ten-m1) (Teneurin transmembrane protein 1) [Cleaved into: Ten-1 intracellular domain (IDten-1) (Ten-1 ICD); Teneurin C-terminal-associated peptide (TCPA-1) (Ten-1 extracellular domain) (Ten-1 ECD)] TENM1 ODZ1 TNM1 Gallus gallus (Chicken) TR42854_c2_g1_i1 A2AX52 CO6A4_MOUSE 3.00E-50 GO:0007155; GO:0005581; GO:0005576; GO:0043234; GO:0070208 cell adhesion; collagen; extracellular region; protein complex; protein heterotrimerization IPR008160; IPR002035; Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) TR42854_c2_g1_i4 P53710 ITA2_BOVIN 5.00E-13 GO:0007155; GO:0008305; GO:0007229; GO:0046872 cell adhesion; integrin complex; integrin-mediated signaling pathway; metal ion binding IPR013517; IPR013519; IPR000413; IPR013649; IPR018184; IPR002035; Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) (Fragment) ITGA2 Bos taurus (Bovine) TR42854_c2_g1_i5 Q4LDE5 SVEP1_HUMAN 1.00E-09 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) TR42854_c2_g3_i1 A8TX70 CO6A5_HUMAN 3.00E-36 GO:0007155; GO:0005581; GO:0030574; GO:0022617; GO:0005576 cell adhesion; collagen; collagen catabolic process; extracellular matrix disassembly; extracellular region IPR008160; IPR002035; Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) (von Willebrand factor A domain-containing protein 4) COL6A5 COL29A1 VWA4 Homo sapiens (Human) TR42857_c0_g3_i1 Q5T3U5 MRP7_HUMAN 9.00E-172 GO:0005524; GO:0006200; GO:0042626; GO:0016021; GO:0005765; GO:0005886; GO:0055085 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; lysosomal membrane; plasma membrane; transmembrane transport" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance-associated protein 7 (ATP-binding cassette sub-family C member 10) ABCC10 MRP7 SIMRP7 Homo sapiens (Human) TR42857_c0_g3_i4 Q9SKX0 AB13C_ARATH 9.00E-133 GO:0005524; GO:0006200; GO:0016021; GO:0008559 ATP binding; ATP catabolic process; integral to membrane; xenobiotic-transporting ATPase activity IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; ABC transporter C family member 13 (ABC transporter ABCC.13) (AtABCC13) (EC 3.6.3.44) (ATP-energized glutathione S-conjugate pump 11) (Glutathione S-conjugate-transporting ATPase 11) (Multidrug resistance-associated protein 11) ABCC13 MRP11 MRP13 At2g07680 T5E7.1 Arabidopsis thaliana (Mouse-ear cress) TR42857_c0_g3_i5 Q5T3U5 MRP7_HUMAN 0 GO:0005524; GO:0006200; GO:0042626; GO:0016021; GO:0005765; GO:0005886; GO:0055085 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; lysosomal membrane; plasma membrane; transmembrane transport" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance-associated protein 7 (ATP-binding cassette sub-family C member 10) ABCC10 MRP7 SIMRP7 Homo sapiens (Human) TR42859_c2_g1_i1 P23470 PTPRG_HUMAN 2.00E-86 GO:0005887; GO:0007169; GO:0005001 P35222 integral to plasma membrane; transmembrane receptor protein tyrosine kinase signaling pathway; transmembrane receptor protein tyrosine phosphatase activity IPR001148; IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48) PTPRG PTPG Homo sapiens (Human) TR42859_c2_g1_i2 Q60673 PTPRN_MOUSE 2.00E-30 GO:0016021; GO:0005886; GO:0004725; GO:0000302; GO:0007185 P18052; P80560 integral to membrane; plasma membrane; protein tyrosine phosphatase activity; response to reactive oxygen species; transmembrane receptor protein tyrosine phosphatase signaling pathway IPR021613; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (PTP IA-2) Ptprn Ptp35 Mus musculus (Mouse) TR42859_c2_g1_i3 P23470 PTPRG_HUMAN 2.00E-86 GO:0005887; GO:0007169; GO:0005001 P35222 integral to plasma membrane; transmembrane receptor protein tyrosine kinase signaling pathway; transmembrane receptor protein tyrosine phosphatase activity IPR001148; IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48) PTPRG PTPG Homo sapiens (Human) TR42859_c2_g1_i4 Q3UQ28 PXDN_MOUSE 3.00E-16 GO:0005783; GO:0031012; GO:0030198; GO:0005201; GO:0005615; GO:0020037; GO:0042744; GO:0046872; GO:0004601; GO:0005578 endoplasmic reticulum; extracellular matrix; extracellular matrix organization; extracellular matrix structural constituent; extracellular space; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity; proteinaceous extracellular matrix IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; IPR001007; Peroxidasin homolog (EC 1.11.1.7) Pxdn Kiaa0230 Mus musculus (Mouse) TR42860_c0_g2_i2 Q3UHC7 DAB2P_MOUSE 0 GO:0007252; GO:0005099; GO:0017124; GO:0000185; GO:0001525; GO:0007049; GO:0021814; GO:0044257; GO:0071347; GO:0071222; GO:0071356; GO:0035924; GO:0044300; GO:0044301; GO:0030425; GO:0030139; GO:0006954; GO:0045087; GO:0070059; GO:0031235; GO:0021819; GO:0070373; GO:0070317; GO:0043124; GO:0043407; GO:0032088; GO:0034261; GO:0046580; GO:0016525; GO:0035414; GO:2000599; GO:0010596; GO:0050680; GO:0010719; GO:0048147; GO:0043553; GO:0014067; GO:0034144; GO:0000122; GO:0030948; GO:1900747; GO:0048812; GO:0032809; GO:1990032; GO:0036312; GO:0032266; GO:0070273; GO:0046330; GO:0043507; GO:0043065; GO:2001235; GO:0071158; GO:1900006; GO:0050679; GO:2001224; GO:1901800; GO:0090129; GO:0045944; GO:0032403; GO:0032312; GO:0040008; GO:1900744; GO:0043254; GO:0006986; GO:0035148; GO:0036324 P97318 I-kappaB phosphorylation; Ras GTPase activator activity; SH3 domain binding; activation of MAPKKK activity; angiogenesis; cell cycle; cell motility involved in cerebral cortex radial glia guided migration; cellular protein catabolic process; cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to tumor necrosis factor; cellular response to vascular endothelial growth factor stimulus; cerebellar mossy fiber; climbing fiber; dendrite; endocytic vesicle; inflammatory response; innate immune response; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic to internal side of plasma membrane; layer formation in cerebral cortex; negative regulation of ERK1 and ERK2 cascade; negative regulation of G0 to G1 transition; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of MAP kinase activity; negative regulation of NF-kappaB transcription factor activity; negative regulation of Ras GTPase activity; negative regulation of Ras protein signal transduction; negative regulation of angiogenesis; negative regulation of catenin import into nucleus; negative regulation of cyclin catabolic process; negative regulation of endothelial cell migration; negative regulation of epithelial cell proliferation; negative regulation of epithelial to mesenchymal transition; negative regulation of fibroblast proliferation; negative regulation of phosphatidylinositol 3-kinase activity; negative regulation of phosphatidylinositol 3-kinase cascade; negative regulation of toll-like receptor 4 signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of vascular endothelial growth factor receptor signaling pathway; negative regulation of vascular endothelial growth factor signaling pathway; neuron projection morphogenesis; neuronal cell body membrane; parallel fiber; phosphatidylinositol 3-kinase regulatory subunit binding; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4-phosphate binding; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of cell cycle arrest; positive regulation of dendrite development; positive regulation of epithelial cell proliferation; positive regulation of neuron migration; positive regulation of proteasomal protein catabolic process; positive regulation of synapse maturation; positive regulation of transcription from RNA polymerase II promoter; protein complex binding; regulation of ARF GTPase activity; regulation of growth; regulation of p38MAPK cascade; regulation of protein complex assembly; response to unfolded protein; tube formation; vascular endothelial growth factor receptor-2 signaling pathway IPR000008; IPR021887; IPR011993; IPR001849; IPR001936; IPR023152; IPR008936; Disabled homolog 2-interacting protein (DAB2-interacting protein) (ASK-interacting protein 1) (DOC-2/DAB-2 interactive protein) Dab2ip Kiaa1743 Mus musculus (Mouse) TR42860_c0_g2_i3 Q8T498 GAP2_DROME 4.00E-159 GO:0005096; GO:0005737; GO:0007476; GO:0002121; GO:0046580; GO:0005543; GO:0043547; GO:0007165 GTPase activator activity; cytoplasm; imaginal disc-derived wing morphogenesis; inter-male aggressive behavior; negative regulation of Ras protein signal transduction; phospholipid binding; positive regulation of GTPase activity; signal transduction IPR000008; IPR021887; IPR001849; IPR001936; IPR023152; IPR008936; Probable Ras GTPase-activating protein CG42684 Drosophila melanogaster (Fruit fly) TR42860_c0_g2_i5 Q3UHC7 DAB2P_MOUSE 0 GO:0007252; GO:0005099; GO:0017124; GO:0000185; GO:0001525; GO:0007049; GO:0021814; GO:0044257; GO:0071347; GO:0071222; GO:0071356; GO:0035924; GO:0044300; GO:0044301; GO:0030425; GO:0030139; GO:0006954; GO:0045087; GO:0070059; GO:0031235; GO:0021819; GO:0070373; GO:0070317; GO:0043124; GO:0043407; GO:0032088; GO:0034261; GO:0046580; GO:0016525; GO:0035414; GO:2000599; GO:0010596; GO:0050680; GO:0010719; GO:0048147; GO:0043553; GO:0014067; GO:0034144; GO:0000122; GO:0030948; GO:1900747; GO:0048812; GO:0032809; GO:1990032; GO:0036312; GO:0032266; GO:0070273; GO:0046330; GO:0043507; GO:0043065; GO:2001235; GO:0071158; GO:1900006; GO:0050679; GO:2001224; GO:1901800; GO:0090129; GO:0045944; GO:0032403; GO:0032312; GO:0040008; GO:1900744; GO:0043254; GO:0006986; GO:0035148; GO:0036324 P97318 I-kappaB phosphorylation; Ras GTPase activator activity; SH3 domain binding; activation of MAPKKK activity; angiogenesis; cell cycle; cell motility involved in cerebral cortex radial glia guided migration; cellular protein catabolic process; cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to tumor necrosis factor; cellular response to vascular endothelial growth factor stimulus; cerebellar mossy fiber; climbing fiber; dendrite; endocytic vesicle; inflammatory response; innate immune response; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; intrinsic to internal side of plasma membrane; layer formation in cerebral cortex; negative regulation of ERK1 and ERK2 cascade; negative regulation of G0 to G1 transition; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of MAP kinase activity; negative regulation of NF-kappaB transcription factor activity; negative regulation of Ras GTPase activity; negative regulation of Ras protein signal transduction; negative regulation of angiogenesis; negative regulation of catenin import into nucleus; negative regulation of cyclin catabolic process; negative regulation of endothelial cell migration; negative regulation of epithelial cell proliferation; negative regulation of epithelial to mesenchymal transition; negative regulation of fibroblast proliferation; negative regulation of phosphatidylinositol 3-kinase activity; negative regulation of phosphatidylinositol 3-kinase cascade; negative regulation of toll-like receptor 4 signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of vascular endothelial growth factor receptor signaling pathway; negative regulation of vascular endothelial growth factor signaling pathway; neuron projection morphogenesis; neuronal cell body membrane; parallel fiber; phosphatidylinositol 3-kinase regulatory subunit binding; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4-phosphate binding; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of cell cycle arrest; positive regulation of dendrite development; positive regulation of epithelial cell proliferation; positive regulation of neuron migration; positive regulation of proteasomal protein catabolic process; positive regulation of synapse maturation; positive regulation of transcription from RNA polymerase II promoter; protein complex binding; regulation of ARF GTPase activity; regulation of growth; regulation of p38MAPK cascade; regulation of protein complex assembly; response to unfolded protein; tube formation; vascular endothelial growth factor receptor-2 signaling pathway IPR000008; IPR021887; IPR011993; IPR001849; IPR001936; IPR023152; IPR008936; Disabled homolog 2-interacting protein (DAB2-interacting protein) (ASK-interacting protein 1) (DOC-2/DAB-2 interactive protein) Dab2ip Kiaa1743 Mus musculus (Mouse) TR42861_c3_g1_i5 Q90744 NAGAB_CHICK 5.00E-128 GO:0008456; GO:0005975; GO:0005764 alpha-N-acetylgalactosaminidase activity; carbohydrate metabolic process; lysosome IPR013785; IPR013780; IPR002241; IPR000111; IPR017853; Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B) NAGA Gallus gallus (Chicken) TR42862_c2_g3_i1 Q90Y54 JAG1B_DANRE 2.00E-12 GO:0007219; GO:0060117; GO:0005509; GO:0060351; GO:0009953; GO:0060325; GO:0016021; GO:0001889; GO:0032474; GO:0031016; GO:0048752; GO:0030878 Notch signaling pathway; auditory receptor cell development; calcium ion binding; cartilage development involved in endochondral bone morphogenesis; dorsal/ventral pattern formation; face morphogenesis; integral to membrane; liver development; otolith morphogenesis; pancreas development; semicircular canal morphogenesis; thyroid gland development IPR001774; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR026219; IPR011651; IPR001007; Protein jagged-1b (Jagged1b) (Jagged3) jag1b jag3 Danio rerio (Zebrafish) (Brachydanio rerio) TR42862_c2_g3_i2 Q9NR61 DLL4_HUMAN 4.00E-11 GO:0005112; GO:0007220; GO:0061314; GO:0008015; GO:0072554; GO:0001974; GO:0005509; GO:0003209; GO:0044344; GO:0035924; GO:0035912; GO:0016021; GO:0090051; GO:0008285; GO:0000122; GO:0001569; GO:0003344; GO:0005886; GO:0050767; GO:0003222 Notch binding; Notch receptor processing; Notch signaling involved in heart development; blood circulation; blood vessel lumenization; blood vessel remodeling; calcium ion binding; cardiac atrium morphogenesis; cellular response to fibroblast growth factor stimulus; cellular response to vascular endothelial growth factor stimulus; dorsal aorta morphogenesis; integral to membrane; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; patterning of blood vessels; pericardium morphogenesis; plasma membrane; regulation of neurogenesis; ventricular trabecula myocardium morphogenesis IPR001774; IPR000742; IPR001881; IPR013032; IPR000152; IPR009030; IPR011651; Delta-like protein 4 (Drosophila Delta homolog 4) (Delta4) DLL4 UNQ1895/PRO4341 Homo sapiens (Human) TR42862_c2_g3_i4 P46531 NOTC1_HUMAN 3.00E-10 GO:0000139; GO:0002193; GO:0007220; GO:0061314; GO:0003270; GO:0001190; GO:0042640; GO:0003180; GO:0060842; GO:0003162; GO:0003181; GO:0009912; GO:0007409; GO:0048754; GO:0005509; GO:0003207; GO:0003214; GO:0060038; GO:0003213; GO:0003219; GO:0060948; GO:0001708; GO:0003273; GO:0009986; GO:0071372; GO:0035924; GO:0031490; GO:0072044; GO:0007386; GO:0001047; GO:0060982; GO:0003169; GO:0005829; GO:0072017; GO:0035116; GO:0060956; GO:0003160; GO:0007492; GO:0005789; GO:0019899; GO:0004857; GO:0003198; GO:0005576; GO:0030900; GO:0007440; GO:0010001; GO:0072144; GO:0003241; GO:0031069; GO:0001947; GO:0006959; GO:0006955; GO:0001701; GO:0002437; GO:0016021; GO:0072602; GO:0030216; GO:0070986; GO:0001889; GO:0030324; GO:0003192; GO:0030514; GO:2000811; GO:0045955; GO:0090090; GO:0090051; GO:0010812; GO:2001027; GO:0060253; GO:0045662; GO:0010832; GO:0048715; GO:0030279; GO:0045668; GO:0046533; GO:2000974; GO:2000737; GO:0000122; GO:0021915; GO:0097150; GO:0005654; GO:0003344; GO:0005886; GO:0030513; GO:0046427; GO:0043065; GO:0048711; GO:0060045; GO:0030335; GO:0050679; GO:0010718; GO:0045618; GO:0061419; GO:0007221; GO:0060740; GO:0003184; GO:0004872; GO:0060768; GO:1901201; GO:0014807; GO:0003256; GO:0032495; GO:0060528; GO:0043565; GO:0003700; GO:0035914; GO:0048103; GO:0002040; GO:0006367; GO:0035148; GO:0060979; GO:0060843; GO:0060412; GO:0003222 P19838; Q13526; Q06330; Q13573; P98170 Golgi membrane; MAML1-RBP-Jkappa- ICN1 complex; Notch receptor processing; Notch signaling involved in heart development; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation; RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; anagen; aortic valve morphogenesis; arterial endothelial cell differentiation; atrioventricular node development; atrioventricular valve morphogenesis; auditory receptor cell fate commitment; axonogenesis; branching morphogenesis of an epithelial tube; calcium ion binding; cardiac chamber formation; cardiac left ventricle morphogenesis; cardiac muscle cell proliferation; cardiac right atrium morphogenesis; cardiac right ventricle formation; cardiac vascular smooth muscle cell development; cell fate specification; cell migration involved in endocardial cushion formation; cell surface; cellular response to follicle-stimulating hormone stimulus; cellular response to vascular endothelial growth factor stimulus; chromatin DNA binding; collecting duct development; compartment pattern specification; core promoter binding; coronary artery morphogenesis; coronary vein morphogenesis; cytosol; distal tubule development; embryonic hindlimb morphogenesis; endocardial cell differentiation; endocardium morphogenesis; endoderm development; endoplasmic reticulum membrane; enzyme binding; enzyme inhibitor activity; epithelial to mesenchymal transition involved in endocardial cushion formation; extracellular region; forebrain development; foregut morphogenesis; glial cell differentiation; glomerular mesangial cell development; growth involved in heart morphogenesis; hair follicle morphogenesis; heart looping; humoral immune response; immune response; in utero embryonic development; inflammatory response to antigenic stimulus; integral to membrane; interleukin-4 secretion; keratinocyte differentiation; left/right axis specification; liver development; lung development; mitral valve formation; negative regulation of BMP signaling pathway; negative regulation of anoikis; negative regulation of calcium ion-dependent exocytosis; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell-substrate adhesion; negative regulation of endothelial cell chemotaxis; negative regulation of glial cell proliferation; negative regulation of myoblast differentiation; negative regulation of myotube differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of ossification; negative regulation of osteoblast differentiation; negative regulation of photoreceptor cell differentiation; negative regulation of pro-B cell differentiation; negative regulation of stem cell differentiation; negative regulation of transcription from RNA polymerase II promoter; neural tube development; neuronal stem cell maintenance; nucleoplasm; pericardium morphogenesis; plasma membrane; positive regulation of BMP signaling pathway; positive regulation of JAK-STAT cascade; positive regulation of apoptotic process; positive regulation of astrocyte differentiation; positive regulation of cardiac muscle cell proliferation; positive regulation of cell migration; positive regulation of epithelial cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription of Notch receptor target; prostate gland epithelium morphogenesis; pulmonary valve morphogenesis; receptor activity; regulation of epithelial cell proliferation involved in prostate gland development; regulation of extracellular matrix assembly; regulation of somitogenesis; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation; response to muramyl dipeptide; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; skeletal muscle cell differentiation; somatic stem cell division; sprouting angiogenesis; transcription initiation from RNA polymerase II promoter; tube formation; vasculogenesis involved in coronary vascular morphogenesis; venous endothelial cell differentiation; ventricular septum morphogenesis; ventricular trabecula myocardium morphogenesis IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022362; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation; Notch 1 intracellular domain (NICD)] NOTCH1 TAN1 Homo sapiens (Human) TR42864_c1_g4_i1 P02512 CRYAB_SQUAC 6.00E-13 GO:0046872; GO:0042803; GO:0005212 metal ion binding; protein homodimerization activity; structural constituent of eye lens IPR002068; IPR001436; IPR012273; IPR003090; IPR008978; Alpha-crystallin B chain (Alpha(B)-crystallin) CRYAB Squalus acanthias (Spiny dogfish) TR42864_c1_g5_i1 P42931 HSP30_ONCTS 5.00E-09 GO:0006950 response to stress IPR002068; IPR001436; IPR008978; Heat shock protein 30 (HSP 30) hsp30 Oncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha) TR42864_c1_g5_i7 Q16082 HSPB2_HUMAN 3.00E-09 GO:0005829; GO:0008047; GO:0005634; GO:0009408; GO:0006986; GO:0007525 Q9UJY1 cytosol; enzyme activator activity; nucleus; response to heat; response to unfolded protein; somatic muscle development IPR002068; IPR001436; IPR008978; Heat shock protein beta-2 (HspB2) (DMPK-binding protein) (MKBP) HSPB2 Homo sapiens (Human) TR42864_c1_g9_i3 P02512 CRYAB_SQUAC 3.00E-14 GO:0046872; GO:0042803; GO:0005212 metal ion binding; protein homodimerization activity; structural constituent of eye lens IPR002068; IPR001436; IPR012273; IPR003090; IPR008978; Alpha-crystallin B chain (Alpha(B)-crystallin) CRYAB Squalus acanthias (Spiny dogfish) TR42865_c2_g1_i5 Q9Y697 NFS1_HUMAN 0 GO:0006777; GO:0031071; GO:0006534; GO:0005829; GO:0018283; GO:0005759; GO:0032324; GO:0005634; GO:0006461; GO:0042803; GO:0030170; GO:0000096; GO:0006767 Mo-molybdopterin cofactor biosynthetic process; cysteine desulfurase activity; cysteine metabolic process; cytosol; iron incorporation into metallo-sulfur cluster; mitochondrial matrix; molybdopterin cofactor biosynthetic process; nucleus; protein complex assembly; protein homodimerization activity; pyridoxal phosphate binding; sulfur amino acid metabolic process; water-soluble vitamin metabolic process IPR000192; IPR020578; IPR010240; IPR016454; IPR015424; IPR015421; IPR015422; "Cysteine desulfurase, mitochondrial (EC 2.8.1.7)" NFS1 NIFS HUSSY-08 Homo sapiens (Human) TR42866_c0_g3_i1 O01393 UNC9_CAEEL 2.00E-96 GO:0005921; GO:0055077; GO:0016021; GO:0034220; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transmembrane transport; plasma membrane IPR000990; Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans TR42866_c0_g3_i3 A8WVX4 INX19_CAEBR 1.00E-86 GO:0030154; GO:0005921; GO:0055077; GO:0016021; GO:0006811; GO:0007399; GO:0005886 cell differentiation; gap junction; gap junction hemi-channel activity; integral to membrane; ion transport; nervous system development; plasma membrane IPR000990; Innexin-19 inx-19 CBG03987 Caenorhabditis briggsae TR42866_c0_g3_i4 O01393 UNC9_CAEEL 5.00E-64 GO:0005921; GO:0055077; GO:0016021; GO:0034220; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transmembrane transport; plasma membrane IPR000990; Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans TR42867_c1_g1_i2 Q9KHE2 Y189_STRGR 9.00E-18 IPR002589; Macro domain-containing protein in non 5'region (ORF1) Streptomyces griseus TR42867_c1_g3_i3 Q460N5 PAR14_HUMAN 2.00E-64 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR42867_c1_g3_i5 Q460N5 PAR14_HUMAN 1.00E-14 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR42868_c0_g4_i1 O43736 ITM2A_HUMAN 2.00E-12 GO:0016021 P05067-4 integral to membrane IPR007084; Integral membrane protein 2A (Protein E25) ITM2A UNQ603/PRO1189 Homo sapiens (Human) TR42869_c0_g1_i1 Q26473 SEM1A_SCHAM 1.00E-140 GO:0030154; GO:0016021; GO:0007399; GO:0004872 cell differentiation; integral to membrane; nervous system development; receptor activity IPR016201; IPR002165; IPR001627; IPR027231; IPR015943; Semaphorin-1A (Fasciclin IV) (Fasciclin-4) (Semaphorin-I) (Sema I) SEMA-1A FAS4 Schistocerca americana (American grasshopper) TR42869_c0_g1_i2 Q64151 SEM4C_MOUSE 2.00E-63 GO:0030054; GO:0021535; GO:0021549; GO:0016021; GO:0042692; GO:0001843; GO:0032874; GO:0014069; GO:0045211; GO:0004872; GO:0071526; GO:0030672 Q9Z0G0; Q9Z2H7 cell junction; cell migration in hindbrain; cerebellum development; integral to membrane; muscle cell differentiation; neural tube closure; positive regulation of stress-activated MAPK cascade; postsynaptic density; postsynaptic membrane; receptor activity; semaphorin-plexin signaling pathway; synaptic vesicle membrane IPR007110; IPR013783; IPR003599; IPR016201; IPR002165; IPR001627; IPR027231; IPR015943; Semaphorin-4C (M-Sema F) (Semaphorin-C-like 1) (Sema I) (Semaphorin I) Sema4c S4c Semacl1 Semai Mus musculus (Mouse) TR42869_c0_g1_i3 Q26473 SEM1A_SCHAM 2.00E-143 GO:0030154; GO:0016021; GO:0007399; GO:0004872 cell differentiation; integral to membrane; nervous system development; receptor activity IPR016201; IPR002165; IPR001627; IPR027231; IPR015943; Semaphorin-1A (Fasciclin IV) (Fasciclin-4) (Semaphorin-I) (Sema I) SEMA-1A FAS4 Schistocerca americana (American grasshopper) TR42869_c0_g1_i4 Q24322 SEM1A_DROME 5.00E-130 GO:0016199; GO:0048854; GO:0048813; GO:0008201; GO:0016021; GO:0031987; GO:0008045; GO:0045792; GO:0005886; GO:0004872; GO:0030215; GO:2000305; GO:0001964; GO:0007416; GO:0008039 axon midline choice point recognition; brain morphogenesis; dendrite morphogenesis; heparin binding; integral to membrane; locomotion involved in locomotory behavior; motor neuron axon guidance; negative regulation of cell size; plasma membrane; receptor activity; semaphorin receptor binding; semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance; startle response; synapse assembly; synaptic target recognition IPR016201; IPR002165; IPR001627; IPR027231; IPR015943; Semaphorin-1A (Semaphorin-I) (Sema I) Sema-1a Dsema-I CG18405 Drosophila melanogaster (Fruit fly) TR42869_c0_g1_i5 Q26972 SEM1A_TRICF 3.00E-126 GO:0030154; GO:0016021; GO:0007399; GO:0004872 cell differentiation; integral to membrane; nervous system development; receptor activity IPR016201; IPR002165; IPR001627; IPR027231; IPR015943; Semaphorin-1A (Semaphorin-I) SEMA-1A TSEMA-I Tribolium confusum (Confused flour beetle) TR42869_c0_g1_i7 Q26473 SEM1A_SCHAM 9.00E-145 GO:0030154; GO:0016021; GO:0007399; GO:0004872 cell differentiation; integral to membrane; nervous system development; receptor activity IPR016201; IPR002165; IPR001627; IPR027231; IPR015943; Semaphorin-1A (Fasciclin IV) (Fasciclin-4) (Semaphorin-I) (Sema I) SEMA-1A FAS4 Schistocerca americana (American grasshopper) TR42869_c0_g1_i9 Q26473 SEM1A_SCHAM 4.00E-143 GO:0030154; GO:0016021; GO:0007399; GO:0004872 cell differentiation; integral to membrane; nervous system development; receptor activity IPR016201; IPR002165; IPR001627; IPR027231; IPR015943; Semaphorin-1A (Fasciclin IV) (Fasciclin-4) (Semaphorin-I) (Sema I) SEMA-1A FAS4 Schistocerca americana (American grasshopper) TR42870_c2_g1_i2 Q08180 ICCR_DROME 1.00E-74 GO:0045177; GO:0005913; GO:0046667; GO:0007156; GO:0016021; GO:0046331; GO:0007520; GO:0005886; GO:0016202 Q9V787; Q0E9F2; Q9W2S5 apical part of cell; cell-cell adherens junction; compound eye retinal cell programmed cell death; homophilic cell adhesion; integral to membrane; lateral inhibition; myoblast fusion; plasma membrane; regulation of striated muscle tissue development IPR013162; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Irregular chiasm C-roughest protein (Protein IRREC) rst CG4125 Drosophila melanogaster (Fruit fly) TR42870_c2_g1_i3 Q8IZU9 KIRR3_HUMAN 2.00E-24 GO:0030424; GO:0043198; GO:0005576; GO:0030097; GO:0016021; GO:0001764; GO:0005886; GO:0021740 axon; dendritic shaft; extracellular region; hemopoiesis; integral to membrane; neuron migration; plasma membrane; principal sensory nucleus of trigeminal nerve development IPR013162; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Kin of IRRE-like protein 3 (Kin of irregular chiasm-like protein 3) (Nephrin-like protein 2) KIRREL3 KIAA1867 NEPH2 UNQ5923/PRO4502/PRO19814 Homo sapiens (Human) TR42871_c2_g3_i2 Q54S04 RPB4_DICDI 1.00E-25 GO:0005665; GO:0003899; GO:0005737; GO:0000166; GO:0006366 "DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase activity; cytoplasm; nucleotide binding; transcription from RNA polymerase II promoter" IPR010997; IPR005574; IPR006590; DNA-directed RNA polymerase II subunit rpb4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) polr2d rpb4 DDB_G0282739 Dictyostelium discoideum (Slime mold) TR42871_c2_g3_i3 Q9D7M8 RPB4_MOUSE 1.00E-61 GO:0005665; GO:0003899; GO:0000166; GO:0006366 "DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase activity; nucleotide binding; transcription from RNA polymerase II promoter" IPR010997; IPR005574; IPR006590; DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) Polr2d Mus musculus (Mouse) TR42871_c3_g3_i2 P28867 KPCD_MOUSE 0 GO:0005524; GO:0042100; GO:0006915; GO:0007049; GO:0005911; GO:0090398; GO:0042742; GO:0005783; GO:0008047; GO:0016064; GO:0032613; GO:0032615; GO:0035556; GO:0016020; GO:0046872; GO:0005739; GO:0043407; GO:0030837; GO:0051490; GO:0034351; GO:0046627; GO:0050732; GO:0090331; GO:0042119; GO:0004715; GO:0016363; GO:0018107; GO:0048471; GO:2001235; GO:0043085; GO:2000304; GO:2000753; GO:1900163; GO:0035307; GO:2001022; GO:2000755; GO:0032930; GO:0004697; GO:0023021 ATP binding; B cell proliferation; apoptotic process; cell cycle; cell-cell junction; cellular senescence; defense response to bacterium; endoplasmic reticulum; enzyme activator activity; immunoglobulin mediated immune response; interleukin-10 production; interleukin-12 production; intracellular signal transduction; membrane; metal ion binding; mitochondrion; negative regulation of MAP kinase activity; negative regulation of actin filament polymerization; negative regulation of filopodium assembly; negative regulation of glial cell apoptotic process; negative regulation of insulin receptor signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of platelet aggregation; neutrophil activation; non-membrane spanning protein tyrosine kinase activity; nuclear matrix; peptidyl-threonine phosphorylation; perinuclear region of cytoplasm; positive regulation of apoptotic signaling pathway; positive regulation of catalytic activity; positive regulation of ceramide biosynthetic process; positive regulation of glucosylceramide catabolic process; positive regulation of phospholipid scramblase activity; positive regulation of protein dephosphorylation; positive regulation of response to DNA damage stimulus; positive regulation of sphingomyelin catabolic process; positive regulation of superoxide anion generation; protein kinase C activity; termination of signal transduction IPR000961; IPR000008; IPR020454; IPR011009; IPR027436; IPR017892; IPR014376; IPR002219; IPR000719; IPR017441; IPR002290; IPR008271; Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] Prkcd Pkcd Mus musculus (Mouse) TR42872_c1_g1_i4 O01391 UCHL_APLCA 5.00E-73 GO:0008234; GO:0005737; GO:0004221; GO:0006511 cysteine-type peptidase activity; cytoplasm; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR001578; Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (Ubiquitin thioesterase) UCH Aplysia californica (California sea hare) TR42874_c0_g2_i1 Q5E9X6 SPSB1_BOVIN 8.00E-135 GO:0005737; GO:0035556; GO:0016567 cytoplasm; intracellular signal transduction; protein ubiquitination IPR001870; IPR008985; IPR001496; IPR018355; IPR003877; Protein modification; protein ubiquitination. SPRY domain-containing SOCS box protein 1 (SSB-1) SPSB1 SSB1 Bos taurus (Bovine) TR42875_c0_g2_i1 O35344 IMA3_MOUSE 8.00E-179 GO:0005737; GO:0005634; GO:0006606; GO:0008565 cytoplasm; nucleus; protein import into nucleus; protein transporter activity IPR011989; IPR016024; IPR000225; IPR002652; IPR024931; Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) Kpna3 Qip2 Mus musculus (Mouse) TR42875_c0_g4_i1 O35343 IMA4_MOUSE 3.00E-91 GO:0005737; GO:0005634; GO:0006606; GO:0008565 cytoplasm; nucleus; protein import into nucleus; protein transporter activity IPR011989; IPR016024; IPR000225; IPR002652; IPR024931; Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4) Kpna4 Qip1 Mus musculus (Mouse) TR42878_c2_g2_i5 Q9NBX4 RTXE_DROME 7.00E-11 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR42878_c2_g3_i1 Q9NBX4 RTXE_DROME 2.00E-14 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR42879_c3_g2_i1 Q5I139 PTPJ2_MDBVW 2.00E-09 GO:0035335; GO:0004725 peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR000387; IPR000242; Probable tyrosine phosphatase protein J2 (PTP-J2) (EC 3.1.3.48) J3 Microplitis demolitor bracovirus (isolate Webb) (MdBV) TR42879_c3_g3_i3 O14522 PTPRT_HUMAN 5.00E-78 GO:0045294; GO:0009986; GO:0045295; GO:0007156; GO:0016021; GO:0005886; GO:0004725; GO:0016790; GO:0007169 P62993; Q99K10; Q69ZK9; Q9CS84; Q6P9K9; Q16849 alpha-catenin binding; cell surface; gamma-catenin binding; homophilic cell adhesion; integral to membrane; plasma membrane; protein tyrosine phosphatase activity; thiolester hydrolase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) TR4288_c0_g2_i1 P16264 SPER_STRPU 5.00E-12 GO:0016021; GO:0005044 integral to membrane; scavenger receptor activity IPR001190; IPR017448; Egg peptide speract receptor Strongylocentrotus purpuratus (Purple sea urchin) TR42881_c2_g1_i10 Q6NSM8 SIK3_DANRE 2.00E-80 GO:0005524; GO:0000287; GO:0004674 ATP binding; magnesium ion binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR015940; Serine/threonine-protein kinase SIK3 homolog (EC 2.7.11.1) (Serine/threonine-protein kinase QSK homolog) zgc:66101 Danio rerio (Zebrafish) (Brachydanio rerio) TR42881_c2_g1_i12 P54646 AAPK2_HUMAN 0 GO:0004679; GO:0005524; GO:0016055; GO:0050405; GO:0047322; GO:0006914; GO:0006853; GO:0007050; GO:0044255; GO:0042149; GO:0006695; GO:0003682; GO:0005829; GO:0006112; GO:0006633; GO:0055089; GO:0042593; GO:0035174; GO:0008286; GO:0008610; GO:0046872; GO:0032007; GO:0043066; GO:0005654; GO:0010508; GO:0045821; GO:0042752; GO:2000505; GO:0042304; GO:0006355; GO:0048511; GO:0044281; GO:0006351 "AMP-activated protein kinase activity; ATP binding; Wnt receptor signaling pathway; [acetyl-CoA carboxylase] kinase activity; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity; autophagy; carnitine shuttle; cell cycle arrest; cellular lipid metabolic process; cellular response to glucose starvation; cholesterol biosynthetic process; chromatin binding; cytosol; energy reserve metabolic process; fatty acid biosynthetic process; fatty acid homeostasis; glucose homeostasis; histone serine kinase activity; insulin receptor signaling pathway; lipid biosynthetic process; metal ion binding; negative regulation of TOR signaling cascade; negative regulation of apoptotic process; nucleoplasm; positive regulation of autophagy; positive regulation of glycolysis; regulation of circadian rhythm; regulation of energy homeostasis; regulation of fatty acid biosynthetic process; regulation of transcription, DNA-dependent; rhythmic process; small molecule metabolic process; transcription, DNA-dependent" IPR028375; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) PRKAA2 AMPK AMPK2 Homo sapiens (Human) TR42881_c2_g1_i2 Q09137 AAPK2_RAT 0 GO:0004679; GO:0031588; GO:0005524; GO:0016055; GO:0050405; GO:0047322; GO:0016324; GO:0006914; GO:0042149; GO:0071417; GO:0006695; GO:0003682; GO:0005737; GO:0006633; GO:0055089; GO:0042593; GO:0035174; GO:0008610; GO:0046872; GO:0032007; GO:0043066; GO:0005654; GO:0010508; GO:0045821; GO:0030674; GO:0051291; GO:0042752; GO:2000505; GO:0019216; GO:0006355; GO:0014823; GO:0031000; GO:0048511; GO:0006351 "AMP-activated protein kinase activity; AMP-activated protein kinase complex; ATP binding; Wnt receptor signaling pathway; [acetyl-CoA carboxylase] kinase activity; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity; apical plasma membrane; autophagy; cellular response to glucose starvation; cellular response to organonitrogen compound; cholesterol biosynthetic process; chromatin binding; cytoplasm; fatty acid biosynthetic process; fatty acid homeostasis; glucose homeostasis; histone serine kinase activity; lipid biosynthetic process; metal ion binding; negative regulation of TOR signaling cascade; negative regulation of apoptotic process; nucleoplasm; positive regulation of autophagy; positive regulation of glycolysis; protein binding, bridging; protein heterooligomerization; regulation of circadian rhythm; regulation of energy homeostasis; regulation of lipid metabolic process; regulation of transcription, DNA-dependent; response to activity; response to caffeine; rhythmic process; transcription, DNA-dependent" IPR028375; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) Prkaa2 Ampk Ampk2 Rattus norvegicus (Rat) TR42881_c2_g1_i4 Q6NSM8 SIK3_DANRE 2.00E-80 GO:0005524; GO:0000287; GO:0004674 ATP binding; magnesium ion binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR015940; Serine/threonine-protein kinase SIK3 homolog (EC 2.7.11.1) (Serine/threonine-protein kinase QSK homolog) zgc:66101 Danio rerio (Zebrafish) (Brachydanio rerio) TR42881_c2_g1_i5 P0C198 CHK1_USTMA 2.00E-33 GO:0005524; GO:0005634; GO:0004674 ATP binding; nucleus; protein serine/threonine kinase activity IPR020636; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase CHK1 (EC 2.7.11.1) (Checkpoint kinase 1) CHK1 UM11087 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) TR42881_c2_g1_i6 P54645 AAPK1_RAT 0 GO:0004679; GO:0031588; GO:0005524; GO:0016055; GO:0050405; GO:0047322; GO:0016324; GO:0006914; GO:0071361; GO:0042149; GO:0070301; GO:0071456; GO:0071417; GO:0006695; GO:0003682; GO:0009631; GO:0005737; GO:0042557; GO:0006633; GO:0055089; GO:0019395; GO:0042593; GO:0006006; GO:0035174; GO:0008610; GO:0046872; GO:0032007; GO:0043066; GO:2001274; GO:0050995; GO:0017148; GO:0005634; GO:0010508; GO:0008284; GO:0046321; GO:0045722; GO:0046326; GO:0045821; GO:0051291; GO:0042752; GO:2000505; GO:0006355; GO:0060627; GO:0014823; GO:0031000; GO:0048511; GO:0050321; GO:0006351 Q76JQ2 "AMP-activated protein kinase activity; AMP-activated protein kinase complex; ATP binding; Wnt receptor signaling pathway; [acetyl-CoA carboxylase] kinase activity; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity; apical plasma membrane; autophagy; cellular response to ethanol; cellular response to glucose starvation; cellular response to hydrogen peroxide; cellular response to hypoxia; cellular response to organonitrogen compound; cholesterol biosynthetic process; chromatin binding; cold acclimation; cytoplasm; eukaryotic elongation factor-2 kinase activator activity; fatty acid biosynthetic process; fatty acid homeostasis; fatty acid oxidation; glucose homeostasis; glucose metabolic process; histone serine kinase activity; lipid biosynthetic process; metal ion binding; negative regulation of TOR signaling cascade; negative regulation of apoptotic process; negative regulation of glucose import in response to insulin stimulus; negative regulation of lipid catabolic process; negative regulation of translation; nucleus; positive regulation of autophagy; positive regulation of cell proliferation; positive regulation of fatty acid oxidation; positive regulation of gluconeogenesis; positive regulation of glucose import; positive regulation of glycolysis; protein heterooligomerization; regulation of circadian rhythm; regulation of energy homeostasis; regulation of transcription, DNA-dependent; regulation of vesicle-mediated transport; response to activity; response to caffeine; rhythmic process; tau-protein kinase activity; transcription, DNA-dependent" IPR028375; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) Prkaa1 Ampk1 Rattus norvegicus (Rat) TR42881_c2_g1_i9 Q09137 AAPK2_RAT 0 GO:0004679; GO:0031588; GO:0005524; GO:0016055; GO:0050405; GO:0047322; GO:0016324; GO:0006914; GO:0042149; GO:0071417; GO:0006695; GO:0003682; GO:0005737; GO:0006633; GO:0055089; GO:0042593; GO:0035174; GO:0008610; GO:0046872; GO:0032007; GO:0043066; GO:0005654; GO:0010508; GO:0045821; GO:0030674; GO:0051291; GO:0042752; GO:2000505; GO:0019216; GO:0006355; GO:0014823; GO:0031000; GO:0048511; GO:0006351 "AMP-activated protein kinase activity; AMP-activated protein kinase complex; ATP binding; Wnt receptor signaling pathway; [acetyl-CoA carboxylase] kinase activity; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity; apical plasma membrane; autophagy; cellular response to glucose starvation; cellular response to organonitrogen compound; cholesterol biosynthetic process; chromatin binding; cytoplasm; fatty acid biosynthetic process; fatty acid homeostasis; glucose homeostasis; histone serine kinase activity; lipid biosynthetic process; metal ion binding; negative regulation of TOR signaling cascade; negative regulation of apoptotic process; nucleoplasm; positive regulation of autophagy; positive regulation of glycolysis; protein binding, bridging; protein heterooligomerization; regulation of circadian rhythm; regulation of energy homeostasis; regulation of lipid metabolic process; regulation of transcription, DNA-dependent; response to activity; response to caffeine; rhythmic process; transcription, DNA-dependent" IPR028375; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) Prkaa2 Ampk Ampk2 Rattus norvegicus (Rat) TR42882_c0_g2_i1 Q1ECX4 TLK2_DANRE 0 GO:0005524; GO:0005634; GO:0004674 ATP binding; nucleus; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR027086; Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (PKU-alpha) (Tousled-like kinase 2) tlk2 zgc:136697 Danio rerio (Zebrafish) (Brachydanio rerio) TR42882_c0_g2_i2 Q9M077 AUR1_ARATH 8.00E-22 GO:0005524; GO:0051301; GO:0009504; GO:0035175; GO:0005874; GO:0007067; GO:0031965; GO:0005730; GO:0009524; GO:0005819; GO:0000922 ATP binding; cell division; cell plate; histone kinase activity (H3-S10 specific); microtubule; mitosis; nuclear membrane; nucleolus; phragmoplast; spindle; spindle pole IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase Aurora-1 (AtAur1) (EC 2.7.11.1) (Aurora-like kinase 1) AUR1 At4g32830 T16I18.40 Arabidopsis thaliana (Mouse-ear cress) TR42882_c0_g2_i3 Q1ECX4 TLK2_DANRE 0 GO:0005524; GO:0005634; GO:0004674 ATP binding; nucleus; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR027086; Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (PKU-alpha) (Tousled-like kinase 2) tlk2 zgc:136697 Danio rerio (Zebrafish) (Brachydanio rerio) TR42882_c0_g2_i4 Q1ECX4 TLK2_DANRE 0 GO:0005524; GO:0005634; GO:0004674 ATP binding; nucleus; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR027086; Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (PKU-alpha) (Tousled-like kinase 2) tlk2 zgc:136697 Danio rerio (Zebrafish) (Brachydanio rerio) TR42883_c0_g2_i1 P27546 MAP4_MOUSE 3.00E-28 GO:0051301; GO:0005737; GO:0051294; GO:0005874; GO:0008017; GO:0051012; GO:0072686; GO:0007052; GO:0005886 cell division; cytoplasm; establishment of spindle orientation; microtubule; microtubule binding; microtubule sliding; mitotic spindle; mitotic spindle organization; plasma membrane IPR027324; IPR027323; IPR001084; Microtubule-associated protein 4 (MAP-4) Map4 Mtap4 Mus musculus (Mouse) TR42883_c0_g2_i2 Q6TS35 TAU_SPECI 8.00E-30 GO:0030424; GO:0005829; GO:0042750; GO:0005874; GO:0005886 axon; cytosol; hibernation; microtubule; plasma membrane IPR027324; IPR001084; IPR002955; Microtubule-associated protein tau MAPT Spermophilus citellus (European suslik) (Citellus citellus) TR42883_c0_g2_i3 P15146 MAP2_RAT 3.00E-33 GO:0030425; GO:0005874; GO:0043025; GO:0043234; GO:0032355; GO:0032570; GO:0005791; GO:0005790 dendrite; microtubule; neuronal cell body; protein complex; response to estradiol stimulus; response to progesterone stimulus; rough endoplasmic reticulum; smooth endoplasmic reticulum IPR027324; IPR013588; IPR001084; Microtubule-associated protein 2 (MAP-2) Map2 Mtap2 Rattus norvegicus (Rat) TR42883_c0_g2_i5 P15146 MAP2_RAT 1.00E-31 GO:0030425; GO:0005874; GO:0043025; GO:0043234; GO:0032355; GO:0032570; GO:0005791; GO:0005790 dendrite; microtubule; neuronal cell body; protein complex; response to estradiol stimulus; response to progesterone stimulus; rough endoplasmic reticulum; smooth endoplasmic reticulum IPR027324; IPR013588; IPR001084; Microtubule-associated protein 2 (MAP-2) Map2 Mtap2 Rattus norvegicus (Rat) TR42885_c1_g7_i1 Q09695 YA22_SCHPO 1.00E-73 GO:0034605; GO:0071472; GO:0004721; GO:0005886; GO:0006470; GO:0007165 cellular response to heat; cellular response to salt stress; phosphoprotein phosphatase activity; plasma membrane; protein dephosphorylation; signal transduction IPR011948; IPR023214; IPR004274; Uncharacterized protein C2F7.02c SPAC2F7.02c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42885_c1_g7_i2 Q9PTJ6 CTDSL_CHICK 1.00E-117 GO:0016311; GO:0046872; GO:0005634; GO:0004721 dephosphorylation; metal ion binding; nucleus; phosphoprotein phosphatase activity IPR011948; IPR023214; IPR004274; CTD small phosphatase-like protein (CTDSP-like) (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 1) (NLI-interacting factor 1) (Small C-terminal domain phosphatase 3) NFI1 NIF Gallus gallus (Chicken) TR42886_c2_g1_i2 Q96PQ7 KLHL5_HUMAN 0 GO:0005737; GO:0005856 cytoplasm; cytoskeleton IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR006652; Kelch-like protein 5 KLHL5 Homo sapiens (Human) TR42886_c2_g1_i3 Q9NR64 KLHL1_HUMAN 0 GO:0003779; GO:0030036; GO:0007628; GO:0021680; GO:0005737; GO:0005856; GO:0030425; GO:0016358; GO:0043025 actin binding; actin cytoskeleton organization; adult walking behavior; cerebellar Purkinje cell layer development; cytoplasm; cytoskeleton; dendrite; dendrite development; neuronal cell body IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR006652; Kelch-like protein 1 KLHL1 KIAA1490 Homo sapiens (Human) TR42887_c1_g2_i1 Q13614 MTMR2_HUMAN 0 GO:0030424; GO:0005829; GO:0097062; GO:0031901; GO:0046855; GO:0032288; GO:0090394; GO:0031642; GO:2000645; GO:0002091; GO:0048666; GO:0097481; GO:0005634; GO:0035335; GO:0006661; GO:0046856; GO:0052866; GO:2000643; GO:0051262; GO:0004725; GO:0008138; GO:0044281; GO:0097060; GO:0008021; GO:0005774 P07196 axon; cytosol; dendritic spine maintenance; early endosome membrane; inositol phosphate dephosphorylation; myelin assembly; negative regulation of excitatory postsynaptic membrane potential; negative regulation of myelination; negative regulation of receptor catabolic process; negative regulation of receptor internalization; neuron development; neuronal postsynaptic density; nucleus; peptidyl-tyrosine dephosphorylation; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; phosphatidylinositol phosphate phosphatase activity; positive regulation of early endosome to late endosome transport; protein tetramerization; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; small molecule metabolic process; synaptic membrane; synaptic vesicle; vacuolar membrane IPR004182; IPR010569; IPR017906; IPR011993; IPR000387; IPR016130; Myotubularin-related protein 2 (EC 3.1.3.-) MTMR2 KIAA1073 Homo sapiens (Human) TR42887_c1_g2_i2 Q8K296 MTMR3_MOUSE 7.00E-75 GO:0046872; GO:0035335; GO:0046856; GO:0004438; GO:0004725 metal ion binding; peptidyl-tyrosine dephosphorylation; phosphatidylinositol dephosphorylation; phosphatidylinositol-3-phosphatase activity; protein tyrosine phosphatase activity IPR010569; IPR017906; IPR016130; IPR000306; IPR017455; IPR011011; IPR013083; Myotubularin-related protein 3 (EC 3.1.3.48) Mtmr3 Mus musculus (Mouse) TR42887_c1_g3_i4 Q5ZIV1 MTMR2_CHICK 1.00E-32 GO:0005737; GO:0016020; GO:0035335; GO:0004725 cytoplasm; membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR004182; IPR010569; IPR017906; IPR011993; IPR000387; IPR016130; Myotubularin-related protein 2 (EC 3.1.3.-) MTMR2 RCJMB04_23g22 Gallus gallus (Chicken) TR42888_c0_g1_i1 Q9HAR2 LPHN3_HUMAN 3.00E-97 GO:0004930; GO:0030246; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; carbohydrate binding; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR001879; IPR003924; IPR015630; IPR003334; IPR000832; IPR017983; IPR000203; IPR000922; IPR003112; Latrophilin-3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Lectomedin-3) LPHN3 KIAA0768 LEC3 Homo sapiens (Human) TR42888_c0_g1_i2 O97817 LPHN2_BOVIN 3.00E-127 GO:0004930; GO:0030246; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; carbohydrate binding; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR001879; IPR003924; IPR003334; IPR000832; IPR017983; IPR000203; IPR000922; IPR003112; Latrophilin-2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) LPHN2 LPH2 Bos taurus (Bovine) TR42888_c0_g1_i3 O97817 LPHN2_BOVIN 1.00E-127 GO:0004930; GO:0030246; GO:0016021; GO:0007218; GO:0005886 G-protein coupled receptor activity; carbohydrate binding; integral to membrane; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR001879; IPR003924; IPR003334; IPR000832; IPR017983; IPR000203; IPR000922; IPR003112; Latrophilin-2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) LPHN2 LPH2 Bos taurus (Bovine) TR42888_c0_g1_i5 O15230 LAMA5_HUMAN 9.00E-17 GO:0001525; GO:0060445; GO:0001658; GO:0016477; GO:0008283; GO:0008037; GO:0042384; GO:0007010; GO:0009790; GO:0045446; GO:0090002; GO:0030198; GO:0005615; GO:0048041; GO:0001942; GO:0005178; GO:0007229; GO:0005606; GO:0043259; GO:0043260; GO:0030324; GO:0001738; GO:0016331; GO:0007517; GO:0001755; GO:0042475; GO:0030155; GO:0030334; GO:0042127; GO:0045995; GO:0005198; GO:0034446 angiogenesis; branching involved in salivary gland morphogenesis; branching involved in ureteric bud morphogenesis; cell migration; cell proliferation; cell recognition; cilium assembly; cytoskeleton organization; embryo development; endothelial cell differentiation; establishment of protein localization to plasma membrane; extracellular matrix organization; extracellular space; focal adhesion assembly; hair follicle development; integrin binding; integrin-mediated signaling pathway; laminin-1 complex; laminin-10 complex; laminin-11 complex; lung development; morphogenesis of a polarized epithelium; morphogenesis of embryonic epithelium; muscle organ development; neural crest cell migration; odontogenesis of dentin-containing tooth; regulation of cell adhesion; regulation of cell migration; regulation of cell proliferation; regulation of embryonic development; structural molecule activity; substrate adhesion-dependent cell spreading IPR008985; IPR013320; IPR013032; IPR002049; IPR018031; IPR000034; IPR001791; IPR009254; IPR010307; IPR008211; IPR001368; Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha) LAMA5 KIAA0533 KIAA1907 Homo sapiens (Human) TR42888_c0_g1_i7 Q00174 LAMA_DROME 3.00E-15 GO:0030424; GO:0007411; GO:0005605; GO:0048854; GO:0007155; GO:0030054; GO:0035001; GO:0016321; GO:0007507; GO:0007476; GO:0002121; GO:0005606; GO:0031987; GO:0035011; GO:0007498; GO:0045886; GO:0036062; GO:0030155; GO:0030334; GO:0045995; GO:0001964; GO:0008021 "axon; axon guidance; basal lamina; brain morphogenesis; cell adhesion; cell junction; dorsal trunk growth, open tracheal system; female meiosis chromosome segregation; heart development; imaginal disc-derived wing morphogenesis; inter-male aggressive behavior; laminin-1 complex; locomotion involved in locomotory behavior; melanotic encapsulation of foreign target; mesoderm development; negative regulation of synaptic growth at neuromuscular junction; presynaptic periactive zone; regulation of cell adhesion; regulation of cell migration; regulation of embryonic development; startle response; synaptic vesicle" IPR008985; IPR013320; IPR013032; IPR002049; IPR018031; IPR000034; IPR001791; IPR009254; IPR010307; IPR008211; Laminin subunit alpha (Laminin A chain) LanA lamA CG10236 Drosophila melanogaster (Fruit fly) TR42889_c2_g2_i1 Q6PFK1 ZN598_DANRE 4.00E-26 GO:0008270 zinc ion binding IPR007087; IPR015880; IPR001841; IPR013083; Zinc finger protein 598 znf598 zfp598 Danio rerio (Zebrafish) (Brachydanio rerio) TR42891_c3_g1_i1 Q9W6V5 PTPRJ_CHICK 4.00E-31 GO:0005911; GO:0016021; GO:0043407; GO:0050860; GO:0042059; GO:0051898; GO:0035335; GO:0016791; GO:0005886; GO:0048008; GO:0051894; GO:0004725; GO:0032587 cell-cell junction; integral to membrane; negative regulation of MAP kinase activity; negative regulation of T cell receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein kinase B signaling cascade; peptidyl-tyrosine dephosphorylation; phosphatase activity; plasma membrane; platelet-derived growth factor receptor signaling pathway; positive regulation of focal adhesion assembly; protein tyrosine phosphatase activity; ruffle membrane IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (Supporting-cell antigen) PTPRJ Gallus gallus (Chicken) TR42891_c3_g2_i1 P35992 PTP10_DROME 2.00E-26 GO:0045177; GO:0030424; GO:0007417; GO:0016021; GO:0007616; GO:0008045; GO:0007424; GO:0005886; GO:0005001 apical part of cell; axon; central nervous system development; integral to membrane; long-term memory; motor neuron axon guidance; open tracheal system development; plasma membrane; transmembrane receptor protein tyrosine phosphatase activity IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase 10D (EC 3.1.3.48) (Receptor-linked protein-tyrosine phosphatase 10D) (DPTP10D) Ptp10D CG1817 Drosophila melanogaster (Fruit fly) TR42891_c3_g2_i2 P23471 PTPRZ_HUMAN 6.00E-62 GO:0007409; GO:0007417; GO:0005887; GO:0072534; GO:0008330; GO:0005578; GO:0005001 Q9UM73 axonogenesis; central nervous system development; integral to plasma membrane; perineuronal net; protein tyrosine/threonine phosphatase activity; proteinaceous extracellular matrix; transmembrane receptor protein tyrosine phosphatase activity IPR001148; IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2) PTPRZ1 HTPZP2 PTPRZ PTPRZ2 PTPZ Homo sapiens (Human) TR42891_c3_g2_i3 P28192 PTP2_CAEEL 2.00E-21 GO:0016021; GO:0035335; GO:0004725 integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR003961; IPR007110; IPR013783; IPR003599; IPR013151; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4) ptp-4 K04D7.4 Caenorhabditis elegans TR42891_c3_g2_i4 P23471 PTPRZ_HUMAN 3.00E-58 GO:0007409; GO:0007417; GO:0005887; GO:0072534; GO:0008330; GO:0005578; GO:0005001 Q9UM73 axonogenesis; central nervous system development; integral to plasma membrane; perineuronal net; protein tyrosine/threonine phosphatase activity; proteinaceous extracellular matrix; transmembrane receptor protein tyrosine phosphatase activity IPR001148; IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2) PTPRZ1 HTPZP2 PTPRZ PTPRZ2 PTPZ Homo sapiens (Human) TR42891_c3_g2_i5 P35822 PTPRK_MOUSE 2.00E-48 GO:0030424; GO:0030425; GO:0016021; GO:0043025; GO:0001750; GO:0004725 axon; dendrite; integral to membrane; neuronal cell body; photoreceptor outer segment; protein tyrosine phosphatase activity IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) Ptprk Ptpk Mus musculus (Mouse) TR42891_c3_g4_i1 P54637 PTP3_DICDI 4.00E-15 GO:0005737; GO:0007243; GO:0035335; GO:0016791; GO:0034504; GO:0004725; GO:0006970; GO:0042501 cytoplasm; intracellular protein kinase cascade; peptidyl-tyrosine dephosphorylation; phosphatase activity; protein localization to nucleus; protein tyrosine phosphatase activity; response to osmotic stress; serine phosphorylation of STAT protein IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase 3 (EC 3.1.3.48) (Protein-tyrosine-phosphate phosphohydrolase 3) ptpC ptp3 DDB_G0282145 Dictyostelium discoideum (Slime mold) TR42892_c3_g1_i2 O88280 SLIT3_RAT 2.00E-19 GO:0007420; GO:0005509; GO:0030154; GO:0005576; GO:0016020; GO:0021510 brain development; calcium ion binding; cell differentiation; extracellular region; membrane; spinal cord development IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; Slit homolog 3 protein (Slit-3) (Multiple epidermal growth factor-like domains protein 5) (Multiple EGF-like domains protein 5) Slit3 Megf5 Rattus norvegicus (Rat) TR42892_c3_g1_i3 B5T267 TLR2_BOSIN 5.00E-23 GO:0002755; GO:0006954; GO:0045087; GO:0016021; GO:0050729; GO:0050707; GO:0002237; GO:0034134; GO:0004888 MyD88-dependent toll-like receptor signaling pathway; inflammatory response; innate immune response; integral to membrane; positive regulation of inflammatory response; regulation of cytokine secretion; response to molecule of bacterial origin; toll-like receptor 2 signaling pathway; transmembrane signaling receptor activity IPR000483; IPR001611; IPR003591; IPR000157; IPR027185; IPR017241; Toll-like receptor 2 (CD antigen CD282) TLR2 Bos indicus (Zebu) TR42892_c3_g1_i4 A4IIW9 LIGO1_XENTR 3.00E-17 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 lingo1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42895_c2_g1_i1 P0C6B8 SVEP1_RAT 2.00E-06 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) TR42895_c2_g1_i3 P0C6B8 SVEP1_RAT 2.00E-06 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) TR42896_c0_g1_i2 P41823 SY65_APLCA 1.00E-06 GO:0000149; GO:0005509; GO:0030054; GO:0030285; GO:0045955; GO:0016079; GO:0005215 SNARE binding; calcium ion binding; cell junction; integral to synaptic vesicle membrane; negative regulation of calcium ion-dependent exocytosis; synaptic vesicle exocytosis; transporter activity IPR000008; IPR001565; Synaptotagmin-1 (Synaptotagmin I) (p65) SYT1 Aplysia californica (California sea hare) TR42896_c0_g2_i1 Q3TZZ7 ESYT2_MOUSE 2.00E-140 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR000008; Extended synaptotagmin-2 (E-Syt2) Esyt2 D12Ertd551e Fam62b Mus musculus (Mouse) TR42897_c0_g1_i10 Q498J9 MBLC1_XENLA 2.00E-47 GO:0016787; GO:0046872 hydrolase activity; metal ion binding IPR001279; Metallo-beta-lactamase domain-containing protein 1 (EC 3.-.-.-) mblac1 Xenopus laevis (African clawed frog) TR42897_c0_g1_i3 Q498J9 MBLC1_XENLA 2.00E-48 GO:0016787; GO:0046872 hydrolase activity; metal ion binding IPR001279; Metallo-beta-lactamase domain-containing protein 1 (EC 3.-.-.-) mblac1 Xenopus laevis (African clawed frog) TR42897_c0_g1_i6 A4D2B0 MBLC1_HUMAN 1.00E-33 GO:0016787; GO:0046872 hydrolase activity; metal ion binding IPR001279; Metallo-beta-lactamase domain-containing protein 1 (EC 3.-.-.-) MBLAC1 Homo sapiens (Human) TR42897_c0_g1_i8 Q498J9 MBLC1_XENLA 1.00E-48 GO:0016787; GO:0046872 hydrolase activity; metal ion binding IPR001279; Metallo-beta-lactamase domain-containing protein 1 (EC 3.-.-.-) mblac1 Xenopus laevis (African clawed frog) TR42897_c0_g1_i9 Q57744 Y296_METJA 6.00E-09 GO:0016787 hydrolase activity IPR001279; Uncharacterized protein MJ0296 MJ0296 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR42898_c1_g2_i1 Q9C0H5 RHG39_HUMAN 1.00E-43 GO:0007411; GO:0005856; GO:0005829; GO:0005634; GO:0051056; GO:0007264 axon guidance; cytoskeleton; cytosol; nucleus; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR000857; IPR008936; IPR000198; IPR001202; Rho GTPase-activating protein 39 ARHGAP39 KIAA1688 Homo sapiens (Human) TR42898_c1_g3_i1 Q9C0H5 RHG39_HUMAN 1.00E-175 GO:0007411; GO:0005856; GO:0005829; GO:0005634; GO:0051056; GO:0007264 axon guidance; cytoskeleton; cytosol; nucleus; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR000857; IPR008936; IPR000198; IPR001202; Rho GTPase-activating protein 39 ARHGAP39 KIAA1688 Homo sapiens (Human) TR42898_c1_g3_i2 P18890 RHG39_RAT 2.00E-42 GO:0005622; GO:0007165 intracellular; signal transduction IPR008936; IPR000198; Rho GTPase-activating protein 39 (Preoptic regulatory factor 2) (PORF-2) (Fragment) Arhgap39 Rattus norvegicus (Rat) TR42899_c0_g3_i1 O46036 CTBP_DROME 0 GO:0051287; GO:0016055; GO:0022416; GO:0001700; GO:0000122; GO:0005634; GO:0016616; GO:0046427; GO:0042803; GO:0030111; GO:0016360; GO:0003713; GO:0003714; GO:0006351; GO:0035220 Itself; P14003; P10734; P08044 "NAD binding; Wnt receptor signaling pathway; chaeta development; embryonic development via the syncytial blastoderm; negative regulation of transcription from RNA polymerase II promoter; nucleus; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; positive regulation of JAK-STAT cascade; protein homodimerization activity; regulation of Wnt receptor signaling pathway; sensory organ precursor cell fate determination; transcription coactivator activity; transcription corepressor activity; transcription, DNA-dependent; wing disc development" IPR006139; IPR006140; IPR016040; C-terminal-binding protein (CtBP protein) (dCtBP) CtBP CG7583 Drosophila melanogaster (Fruit fly) TR42900_c0_g1_i1 O08528 HXK2_MOUSE 2.00E-105 GO:0005524; GO:0008637; GO:0001678; GO:0005829; GO:0008865; GO:0004340; GO:0005536; GO:0006096; GO:0007595; GO:0019158; GO:0005741; GO:0005739; GO:0046324 ATP binding; apoptotic mitochondrial changes; cellular glucose homeostasis; cytosol; fructokinase activity; glucokinase activity; glucose binding; glycolysis; lactation; mannokinase activity; mitochondrial outer membrane; mitochondrion; regulation of glucose import IPR001312; IPR022673; IPR019807; IPR022672; Carbohydrate metabolism; hexose metabolism. Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) Hk2 Mus musculus (Mouse) TR42900_c0_g1_i10 P52789 HXK2_HUMAN 7.00E-106 GO:0005524; GO:0008637; GO:0001678; GO:0005829; GO:0008865; GO:0004340; GO:0005536; GO:0015758; GO:0006096; GO:0007595; GO:0019158; GO:0005741; GO:0046324; GO:0044281; GO:0055085 ATP binding; apoptotic mitochondrial changes; cellular glucose homeostasis; cytosol; fructokinase activity; glucokinase activity; glucose binding; glucose transport; glycolysis; lactation; mannokinase activity; mitochondrial outer membrane; regulation of glucose import; small molecule metabolic process; transmembrane transport IPR001312; IPR022673; IPR019807; IPR022672; Carbohydrate metabolism; hexose metabolism. Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Muscle form hexokinase) HK2 Homo sapiens (Human) TR42900_c0_g1_i2 Q9NFT7 HXK2_DROME 3.00E-120 GO:0005524; GO:0001678; GO:0005829; GO:0008865; GO:0004340; GO:0006096; GO:0019158 ATP binding; cellular glucose homeostasis; cytosol; fructokinase activity; glucokinase activity; glycolysis; mannokinase activity IPR001312; IPR022673; IPR019807; IPR022672; Carbohydrate metabolism; hexose metabolism. Hexokinase type 2 (EC 2.7.1.1) Hex-t2 Hex CG32849 Drosophila melanogaster (Fruit fly) TR42900_c0_g1_i3 P27595 HXK1_BOVIN 1.00E-100 GO:0005524; GO:0005829; GO:0006096; GO:0004396; GO:0005741; GO:0005739 ATP binding; cytosol; glycolysis; hexokinase activity; mitochondrial outer membrane; mitochondrion IPR001312; IPR022673; IPR019807; IPR022672; Carbohydrate metabolism; hexose metabolism. Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) HK1 Bos taurus (Bovine) TR42900_c0_g1_i5 P52789 HXK2_HUMAN 2.00E-111 GO:0005524; GO:0008637; GO:0001678; GO:0005829; GO:0008865; GO:0004340; GO:0005536; GO:0015758; GO:0006096; GO:0007595; GO:0019158; GO:0005741; GO:0046324; GO:0044281; GO:0055085 ATP binding; apoptotic mitochondrial changes; cellular glucose homeostasis; cytosol; fructokinase activity; glucokinase activity; glucose binding; glucose transport; glycolysis; lactation; mannokinase activity; mitochondrial outer membrane; regulation of glucose import; small molecule metabolic process; transmembrane transport IPR001312; IPR022673; IPR019807; IPR022672; Carbohydrate metabolism; hexose metabolism. Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Muscle form hexokinase) HK2 Homo sapiens (Human) TR42900_c0_g1_i6 P17712 HXK4_RAT 4.00E-106 GO:0043531; GO:0005524; GO:0006739; GO:0070509; GO:0005938; GO:0001678; GO:0042149; GO:0032869; GO:0044320; GO:0005829; GO:0051594; GO:0007204; GO:0006003; GO:0004340; GO:0005536; GO:0005978; GO:0006096; GO:0000287; GO:0005739; GO:0032811; GO:0045721; GO:0005654; GO:0045725; GO:0045821; GO:0032024; GO:0042327; GO:0043266; GO:0019932; GO:0030141 "ADP binding; ATP binding; NADP metabolic process; calcium ion import; cell cortex; cellular glucose homeostasis; cellular response to glucose starvation; cellular response to insulin stimulus; cellular response to leptin stimulus; cytosol; detection of glucose; elevation of cytosolic calcium ion concentration; fructose 2,6-bisphosphate metabolic process; glucokinase activity; glucose binding; glycogen biosynthetic process; glycolysis; magnesium ion binding; mitochondrion; negative regulation of epinephrine secretion; negative regulation of gluconeogenesis; nucleoplasm; positive regulation of glycogen biosynthetic process; positive regulation of glycolysis; positive regulation of insulin secretion; positive regulation of phosphorylation; regulation of potassium ion transport; second-messenger-mediated signaling; secretory granule" IPR001312; IPR022673; IPR019807; IPR022672; Glucokinase (EC 2.7.1.2) (Hexokinase type IV) (HK IV) (Hexokinase-4) (HK4) (Hexokinase-D) Gck Rattus norvegicus (Rat) TR42900_c0_g1_i7 Q9NFT7 HXK2_DROME 1.00E-112 GO:0005524; GO:0001678; GO:0005829; GO:0008865; GO:0004340; GO:0006096; GO:0019158 ATP binding; cellular glucose homeostasis; cytosol; fructokinase activity; glucokinase activity; glycolysis; mannokinase activity IPR001312; IPR022673; IPR019807; IPR022672; Carbohydrate metabolism; hexose metabolism. Hexokinase type 2 (EC 2.7.1.1) Hex-t2 Hex CG32849 Drosophila melanogaster (Fruit fly) TR42900_c0_g1_i8 Q91W97 HKDC1_MOUSE 3.00E-99 GO:0005524; GO:0001678; GO:0005829; GO:0008865; GO:0004340; GO:0006096; GO:0019158; GO:0005739; GO:0005634 ATP binding; cellular glucose homeostasis; cytosol; fructokinase activity; glucokinase activity; glycolysis; mannokinase activity; mitochondrion; nucleus IPR001312; IPR022673; IPR019807; IPR022672; Carbohydrate metabolism; hexose metabolism. Putative hexokinase HKDC1 (EC 2.7.1.1) (Hexokinase domain-containing protein 1) Hkdc1 Mus musculus (Mouse) TR42900_c0_g1_i9 Q9NFT7 HXK2_DROME 1.00E-112 GO:0005524; GO:0001678; GO:0005829; GO:0008865; GO:0004340; GO:0006096; GO:0019158 ATP binding; cellular glucose homeostasis; cytosol; fructokinase activity; glucokinase activity; glycolysis; mannokinase activity IPR001312; IPR022673; IPR019807; IPR022672; Carbohydrate metabolism; hexose metabolism. Hexokinase type 2 (EC 2.7.1.1) Hex-t2 Hex CG32849 Drosophila melanogaster (Fruit fly) TR42900_c0_g2_i1 Q26609 HXK_SCHMA 3.00E-28 GO:0005524; GO:0006096; GO:0004396 ATP binding; glycolysis; hexokinase activity IPR001312; IPR022673; IPR019807; IPR022672; Hexokinase (EC 2.7.1.1) Schistosoma mansoni (Blood fluke) TR42900_c0_g2_i2 P17710 HXK1_MOUSE 1.00E-29 GO:0005524; GO:0001678; GO:0005829; GO:0008865; GO:0004340; GO:0006096; GO:0019158; GO:0045121; GO:0005741; GO:0005739 ATP binding; cellular glucose homeostasis; cytosol; fructokinase activity; glucokinase activity; glycolysis; mannokinase activity; membrane raft; mitochondrial outer membrane; mitochondrion IPR001312; IPR022673; IPR019807; IPR022672; Carbohydrate metabolism; hexose metabolism. "Hexokinase-1 (EC 2.7.1.1) (Hexokinase type I) (HK I) (Hexokinase, tumor isozyme)" Hk1 Mus musculus (Mouse) TR42900_c0_g2_i3 P27881 HXK2_RAT 1.00E-32 GO:0005524; GO:0001678; GO:0005829; GO:0008865; GO:0004340; GO:0005536; GO:0006096; GO:0007595; GO:0019158; GO:0005741; GO:0002931 ATP binding; cellular glucose homeostasis; cytosol; fructokinase activity; glucokinase activity; glucose binding; glycolysis; lactation; mannokinase activity; mitochondrial outer membrane; response to ischemia IPR001312; IPR022673; IPR019807; IPR022672; Carbohydrate metabolism; hexose metabolism. Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) Hk2 Rattus norvegicus (Rat) TR42902_c1_g1_i4 Q63415 PCSK6_RAT 1.00E-36 GO:0005794; GO:0005615; GO:0016486; GO:0006508; GO:0004252 Golgi apparatus; extracellular space; peptide hormone processing; proteolysis; serine-type endopeptidase activity IPR000742; IPR006212; IPR008979; IPR009030; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR010909; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4) Pcsk6 Pace4 Rattus norvegicus (Rat) TR42904_c1_g3_i1 P06280 AGAL_HUMAN 1.00E-121 GO:0005794; GO:0004557; GO:0005576; GO:0016936; GO:0016139; GO:0046477; GO:0043202; GO:0045019; GO:0051001; GO:0009311; GO:0042803; GO:0052692; GO:0005102; GO:0044281 Golgi apparatus; alpha-galactosidase activity; extracellular region; galactoside binding; glycoside catabolic process; glycosylceramide catabolic process; lysosomal lumen; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; oligosaccharide metabolic process; protein homodimerization activity; raffinose alpha-galactosidase activity; receptor binding; small molecule metabolic process IPR013785; IPR013780; IPR002241; IPR000111; IPR017853; Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Melibiase) (Agalsidase) GLA Homo sapiens (Human) TR42905_c0_g1_i1 Q99323 MYSN_DROME 0 GO:0005524; GO:0042623; GO:0007443; GO:0030018; GO:0007496; GO:0045179; GO:0007298; GO:0032154; GO:0035017; GO:0046664; GO:0046663; GO:0007395; GO:0045200; GO:0001736; GO:0045184; GO:0008258; GO:0035317; GO:0070986; GO:0003774; GO:0006936; GO:0016460; GO:0031036; GO:0051259; GO:0051726; GO:0035159; GO:0007435; GO:0045214; GO:0016461; GO:0042060 "ATP binding; ATPase activity, coupled; Malpighian tubule morphogenesis; Z disc; anterior midgut development; apical cortex; border follicle cell migration; cleavage furrow; cuticle pattern formation; dorsal closure, amnioserosa morphology change; dorsal closure, leading edge cell differentiation; dorsal closure, spreading of leading edge cells; establishment of neuroblast polarity; establishment of planar polarity; establishment of protein localization; head involution; imaginal disc-derived wing hair organization; left/right axis specification; motor activity; muscle contraction; myosin II complex; myosin II filament assembly; protein oligomerization; regulation of cell cycle; regulation of tube length, open tracheal system; salivary gland morphogenesis; sarcomere organization; unconventional myosin complex; wound healing" IPR000048; IPR027401; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, non-muscle (Myosin II) (Non-muscle MHC) (Zipper protein)" zip CG15792 Drosophila melanogaster (Fruit fly) TR42905_c0_g1_i2 Q9JMH9 MY18A_MOUSE 3.00E-66 GO:0043531; GO:0005524; GO:0007030; GO:0048194; GO:0042641; GO:0031032; GO:0016477; GO:0005856; GO:0005793; GO:0003774; GO:0016459; GO:0050714; GO:0005802 ADP binding; ATP binding; Golgi organization; Golgi vesicle budding; actomyosin; actomyosin structure organization; cell migration; cytoskeleton; endoplasmic reticulum-Golgi intermediate compartment; motor activity; myosin complex; positive regulation of protein secretion; trans-Golgi network IPR000048; IPR027401; IPR001609; IPR002928; IPR027417; IPR001478; Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) Myo18a Myspdz Mus musculus (Mouse) TR42905_c0_g1_i3 Q27991 MYH10_BOVIN 0 GO:0005524; GO:0007512; GO:0030424; GO:0007411; GO:0055003; GO:0005938; GO:0008283; GO:0021680; GO:0005737; GO:0043197; GO:0006887; GO:0021592; GO:0030426; GO:0001701; GO:0021670; GO:0000281; GO:0003774; GO:0016460; GO:0031594; GO:0050885; GO:0001764; GO:0043025; GO:0007097; GO:0005886; GO:0001778; GO:0008360; GO:0060041; GO:0005819; GO:0001725; GO:0006930; GO:0021678; GO:0055015 "ATP binding; adult heart development; axon; axon guidance; cardiac myofibril assembly; cell cortex; cell proliferation; cerebellar Purkinje cell layer development; cytoplasm; dendritic spine; exocytosis; fourth ventricle development; growth cone; in utero embryonic development; lateral ventricle development; mitotic cytokinesis; motor activity; myosin II complex; neuromuscular junction; neuromuscular process controlling balance; neuron migration; neuronal cell body; nuclear migration; plasma membrane; plasma membrane repair; regulation of cell shape; retina development in camera-type eye; spindle; stress fiber; substrate-dependent cell migration, cell extension; third ventricle development; ventricular cardiac muscle cell development" IPR000048; IPR027401; IPR001609; IPR004009; IPR008989; IPR002928; IPR027417; "Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB)" MYH10 Bos taurus (Bovine) TR42905_c0_g1_i4 Q63862 MYH11_RAT 0 GO:0005524; GO:0042470; GO:0003774; GO:0005859; GO:0030016; GO:0032982; GO:0006939; GO:0008307 ATP binding; melanosome; motor activity; muscle myosin complex; myofibril; myosin filament; smooth muscle contraction; structural constituent of muscle IPR000048; IPR027401; IPR001609; IPR002928; IPR027417; "Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) (Fragments)" Myh11 Rattus norvegicus (Rat) TR42905_c0_g2_i1 Q99323 MYSN_DROME 0 GO:0005524; GO:0042623; GO:0007443; GO:0030018; GO:0007496; GO:0045179; GO:0007298; GO:0032154; GO:0035017; GO:0046664; GO:0046663; GO:0007395; GO:0045200; GO:0001736; GO:0045184; GO:0008258; GO:0035317; GO:0070986; GO:0003774; GO:0006936; GO:0016460; GO:0031036; GO:0051259; GO:0051726; GO:0035159; GO:0007435; GO:0045214; GO:0016461; GO:0042060 "ATP binding; ATPase activity, coupled; Malpighian tubule morphogenesis; Z disc; anterior midgut development; apical cortex; border follicle cell migration; cleavage furrow; cuticle pattern formation; dorsal closure, amnioserosa morphology change; dorsal closure, leading edge cell differentiation; dorsal closure, spreading of leading edge cells; establishment of neuroblast polarity; establishment of planar polarity; establishment of protein localization; head involution; imaginal disc-derived wing hair organization; left/right axis specification; motor activity; muscle contraction; myosin II complex; myosin II filament assembly; protein oligomerization; regulation of cell cycle; regulation of tube length, open tracheal system; salivary gland morphogenesis; sarcomere organization; unconventional myosin complex; wound healing" IPR000048; IPR027401; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, non-muscle (Myosin II) (Non-muscle MHC) (Zipper protein)" zip CG15792 Drosophila melanogaster (Fruit fly) TR42905_c0_g2_i2 Q8VDD5 MYH9_MOUSE 0 GO:0043531; GO:0005524; GO:0016887; GO:0008180; GO:0031532; GO:0051015; GO:0030048; GO:0030898; GO:0005826; GO:0001525; GO:0043534; GO:0005913; GO:0016337; GO:0032154; GO:0030863; GO:0000910; GO:0005829; GO:0001768; GO:0051295; GO:0070062; GO:0001701; GO:0008305; GO:0000212; GO:0006509; GO:0000146; GO:0030224; GO:0007520; GO:0016460; GO:0005634; GO:0005886; GO:0030220; GO:0043495; GO:0042803; GO:0015031; GO:0008360; GO:0001726; GO:0001725; GO:0001931; GO:0032796 Q923J1 ADP binding; ATP binding; ATPase activity; COP9 signalosome; actin cytoskeleton reorganization; actin filament binding; actin filament-based movement; actin-dependent ATPase activity; actomyosin contractile ring; angiogenesis; blood vessel endothelial cell migration; cell-cell adherens junction; cell-cell adhesion; cleavage furrow; cortical cytoskeleton; cytokinesis; cytosol; establishment of T cell polarity; establishment of meiotic spindle localization; extracellular vesicular exosome; in utero embryonic development; integrin complex; meiotic spindle organization; membrane protein ectodomain proteolysis; microfilament motor activity; monocyte differentiation; myoblast fusion; myosin II complex; nucleus; plasma membrane; platelet formation; protein anchor; protein homodimerization activity; protein transport; regulation of cell shape; ruffle; stress fiber; uropod; uropod organization IPR000048; IPR027401; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)" Myh9 Mus musculus (Mouse) TR42906_c0_g1_i3 P31421 GRM2_RAT 8.00E-24 GO:0030424; GO:0005246; GO:0030054; GO:0030425; GO:0014047; GO:0001641; GO:0005887; GO:0005622; GO:0042734; GO:0046928; GO:0051966 P14842; Q96S59 "axon; calcium channel regulator activity; cell junction; dendrite; glutamate secretion; group II metabotropic glutamate receptor activity; integral to plasma membrane; intracellular; presynaptic membrane; regulation of neurotransmitter secretion; regulation of synaptic transmission, glutamatergic" IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR000162; IPR001458; IPR028082; Metabotropic glutamate receptor 2 (mGluR2) Grm2 Gprc1b Mglur2 Rattus norvegicus (Rat) TR42906_c0_g1_i5 P31421 GRM2_RAT 1.00E-23 GO:0030424; GO:0005246; GO:0030054; GO:0030425; GO:0014047; GO:0001641; GO:0005887; GO:0005622; GO:0042734; GO:0046928; GO:0051966 P14842; Q96S59 "axon; calcium channel regulator activity; cell junction; dendrite; glutamate secretion; group II metabotropic glutamate receptor activity; integral to plasma membrane; intracellular; presynaptic membrane; regulation of neurotransmitter secretion; regulation of synaptic transmission, glutamatergic" IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR000162; IPR001458; IPR028082; Metabotropic glutamate receptor 2 (mGluR2) Grm2 Gprc1b Mglur2 Rattus norvegicus (Rat) TR42908_c2_g3_i1 Q9Z2X3 PSD10_RAT 6.00E-17 GO:0006915; GO:0005737; GO:0007253; GO:0043518; GO:0043409; GO:0032088; GO:0043066; GO:0090201; GO:0000122; GO:0005634; GO:0030307; GO:0045737; GO:0032436; GO:0031398; GO:0070682 "apoptotic process; cytoplasm; cytoplasmic sequestering of NF-kappaB; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of MAPK cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of apoptotic process; negative regulation of release of cytochrome c from mitochondria; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of cell growth; positive regulation of cyclin-dependent protein kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; proteasome regulatory particle assembly" IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) Psmd10 Rattus norvegicus (Rat) TR42908_c2_g3_i2 Q5ZIJ9 MIB2_CHICK 5.00E-153 GO:0007219; GO:0005737; GO:0004842; GO:0008270 Notch signaling pathway; cytoplasm; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) TR42911_c0_g3_i2 O57429 UBP2_CHICK 4.00E-99 GO:0046872; GO:0048471; GO:0016579; GO:0004221; GO:0006511; GO:0004843 metal ion binding; perinuclear region of cytoplasm; protein deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) USP2 UBP41 Gallus gallus (Chicken) TR42912_c1_g1_i2 B5DF93 PATL1_RAT 2.00E-48 GO:0030014; GO:0016605; GO:0003723; GO:0000932; GO:0033962; GO:0000290; GO:0016607; GO:0034046; GO:0008266 CCR4-NOT complex; PML body; RNA binding; cytoplasmic mRNA processing body; cytoplasmic mRNA processing body assembly; deadenylation-dependent decapping of nuclear-transcribed mRNA; nuclear speck; poly(G) RNA binding; poly(U) RNA binding IPR019167; Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) Patl1 Rattus norvegicus (Rat) TR42912_c1_g1_i5 Q20374 PATR1_CAEEL 2.00E-07 GO:0003723; GO:0000932 RNA binding; cytoplasmic mRNA processing body IPR019167; Protein PAT1 homolog 1 patr-1 F43G6.9 Caenorhabditis elegans TR42912_c1_g1_i7 A2RRV3 PATL1_DANRE 3.00E-48 GO:0016605; GO:0003723; GO:0000932; GO:0033962; GO:0000290; GO:0016607 PML body; RNA binding; cytoplasmic mRNA processing body; cytoplasmic mRNA processing body assembly; deadenylation-dependent decapping of nuclear-transcribed mRNA; nuclear speck IPR019167; Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) patl1 zgc:158239 Danio rerio (Zebrafish) (Brachydanio rerio) TR42913_c1_g1_i1 Q96D46 NMD3_HUMAN 0 GO:0005737; GO:0005730; GO:0005654; GO:0015031 cytoplasm; nucleolus; nucleoplasm; protein transport IPR007064; 60S ribosomal export protein NMD3 (hNMD3) NMD3 CGI-07 Homo sapiens (Human) TR42914_c0_g1_i5 Q9UJT1 TBD_HUMAN 7.00E-10 GO:0005525; GO:0003924; GO:0005794; GO:0030154; GO:0005814; GO:0005874; GO:0007017; GO:0007275; GO:0005634; GO:0051258; GO:0007283; GO:0005200 GTP binding; GTPase activity; Golgi apparatus; cell differentiation; centriole; microtubule; microtubule-based process; multicellular organismal development; nucleus; protein polymerization; spermatogenesis; structural constituent of cytoskeleton IPR002967; IPR008280; IPR000217; IPR023123; IPR017975; IPR003008; Tubulin delta chain (Delta-tubulin) TUBD1 TUBD Homo sapiens (Human) TR42914_c0_g2_i1 Q9XFG3 TBG_PHYPA 7.00E-06 GO:0005525; GO:0003924; GO:0031122; GO:0000930; GO:0005874; GO:0007020; GO:0051258 GTP binding; GTPase activity; cytoplasmic microtubule organization; gamma-tubulin complex; microtubule; microtubule nucleation; protein polymerization IPR002454; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin gamma chain (Gamma-tubulin) TUBG1 PHYPADRAFT_170153 Physcomitrella patens subsp. patens (Moss) TR42914_c0_g2_i2 Q42480 TBB1_CHOCR 5.00E-07 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta-1 chain (Beta-1-tubulin) TUBB TUB1 Chondrus crispus (Carragheen moss) (Irish moss) TR42914_c0_g2_i3 Q00264 TBB_ASPPA 6.00E-08 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR013838; IPR002453; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin beta chain (Beta-tubulin) benR Aspergillus parasiticus TR42915_c0_g3_i1 Q61527 ERBB4_MOUSE 1.00E-35 GO:0005524; GO:0016323; GO:0061026; GO:0045165; GO:0021551; GO:0009880; GO:0007507; GO:0016021; GO:0007595; GO:0060749; GO:0060644; GO:0043653; GO:0005739; GO:0043066; GO:0008285; GO:0001755; GO:0005634; GO:0021889; GO:0070374; GO:2000366; GO:0060045; GO:0043552; GO:0045893; GO:0042523; GO:0046777; GO:0004716; GO:0030334; GO:0023014; GO:0044212; GO:0006351; GO:0004714; GO:0007169 Q9NZC7 "ATP binding; basolateral plasma membrane; cardiac muscle tissue regeneration; cell fate commitment; central nervous system morphogenesis; embryonic pattern specification; heart development; integral to membrane; lactation; mammary gland alveolus development; mammary gland epithelial cell differentiation; mitochondrial fragmentation involved in apoptotic process; mitochondrion; negative regulation of apoptotic process; negative regulation of cell proliferation; neural crest cell migration; nucleus; olfactory bulb interneuron differentiation; positive regulation of ERK1 and ERK2 cascade; positive regulation of STAT protein import into nucleus; positive regulation of cardiac muscle cell proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat5 protein; protein autophosphorylation; receptor signaling protein tyrosine kinase activity; regulation of cell migration; signal transduction by phosphorylation; transcription regulatory region DNA binding; transcription, DNA-dependent; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway" IPR000494; IPR006211; IPR006212; IPR009030; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR016245; Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] Erbb4 Mer4 Mus musculus (Mouse) TR42915_c0_g3_i2 Q61527 ERBB4_MOUSE 2.00E-42 GO:0005524; GO:0016323; GO:0061026; GO:0045165; GO:0021551; GO:0009880; GO:0007507; GO:0016021; GO:0007595; GO:0060749; GO:0060644; GO:0043653; GO:0005739; GO:0043066; GO:0008285; GO:0001755; GO:0005634; GO:0021889; GO:0070374; GO:2000366; GO:0060045; GO:0043552; GO:0045893; GO:0042523; GO:0046777; GO:0004716; GO:0030334; GO:0023014; GO:0044212; GO:0006351; GO:0004714; GO:0007169 Q9NZC7 "ATP binding; basolateral plasma membrane; cardiac muscle tissue regeneration; cell fate commitment; central nervous system morphogenesis; embryonic pattern specification; heart development; integral to membrane; lactation; mammary gland alveolus development; mammary gland epithelial cell differentiation; mitochondrial fragmentation involved in apoptotic process; mitochondrion; negative regulation of apoptotic process; negative regulation of cell proliferation; neural crest cell migration; nucleus; olfactory bulb interneuron differentiation; positive regulation of ERK1 and ERK2 cascade; positive regulation of STAT protein import into nucleus; positive regulation of cardiac muscle cell proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat5 protein; protein autophosphorylation; receptor signaling protein tyrosine kinase activity; regulation of cell migration; signal transduction by phosphorylation; transcription regulatory region DNA binding; transcription, DNA-dependent; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway" IPR000494; IPR006211; IPR006212; IPR009030; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR016245; Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] Erbb4 Mer4 Mus musculus (Mouse) TR42916_c1_g4_i1 Q8W0Z9 CCR4A_ARATH 4.00E-26 GO:0003723; GO:0005829; GO:0046872; GO:0090305; GO:0005634; GO:0004535; GO:0006355; GO:0006351 "RNA binding; cytosol; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleus; poly(A)-specific ribonuclease activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR005135; Carbon catabolite repressor protein 4 homolog 1 (CCR4 homolog 1) (EC 3.1.13.4) CCR4-1 At3g58560 F14P22.150 Arabidopsis thaliana (Mouse-ear cress) TR42917_c1_g1_i1 Q9U943 APLP_LOCMI 9.00E-11 GO:0016055; GO:0005576; GO:0008289; GO:0005319 Wnt receptor signaling pathway; extracellular region; lipid binding; lipid transporter activity IPR015819; IPR001747; IPR009454; IPR015816; IPR015255; IPR015817; IPR015818; IPR011030; IPR001846; Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)] Locusta migratoria (Migratory locust) TR42919_c1_g1_i1 Q8K448 ABCA5_MOUSE 2.00E-60 GO:0005524; GO:0006200; GO:0016887; GO:0000139; GO:0033344; GO:0034375; GO:0016021; GO:0005770; GO:0031902; GO:0005765; GO:0005764; GO:0010745; GO:0043691 ATP binding; ATP catabolic process; ATPase activity; Golgi membrane; cholesterol efflux; high-density lipoprotein particle remodeling; integral to membrane; late endosome; late endosome membrane; lysosomal membrane; lysosome; negative regulation of macrophage derived foam cell differentiation; reverse cholesterol transport IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 5 Abca5 Kiaa1888 Mus musculus (Mouse) TR42919_c1_g2_i1 Q8WWZ7 ABCA5_HUMAN 2.00E-151 GO:0005524; GO:0006200; GO:0016887; GO:0000139; GO:0033344; GO:0034375; GO:0016021; GO:0005770; GO:0031902; GO:0005765; GO:0005764; GO:0010745; GO:0043691 ATP binding; ATP catabolic process; ATPase activity; Golgi membrane; cholesterol efflux; high-density lipoprotein particle remodeling; integral to membrane; late endosome; late endosome membrane; lysosomal membrane; lysosome; negative regulation of macrophage derived foam cell differentiation; reverse cholesterol transport IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 5 ABCA5 KIAA1888 Homo sapiens (Human) TR42919_c1_g2_i4 Q8K448 ABCA5_MOUSE 4.00E-133 GO:0005524; GO:0006200; GO:0016887; GO:0000139; GO:0033344; GO:0034375; GO:0016021; GO:0005770; GO:0031902; GO:0005765; GO:0005764; GO:0010745; GO:0043691 ATP binding; ATP catabolic process; ATPase activity; Golgi membrane; cholesterol efflux; high-density lipoprotein particle remodeling; integral to membrane; late endosome; late endosome membrane; lysosomal membrane; lysosome; negative regulation of macrophage derived foam cell differentiation; reverse cholesterol transport IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 5 Abca5 Kiaa1888 Mus musculus (Mouse) TR42921_c3_g1_i1 Q5E946 PARK7_BOVIN 3.00E-70 GO:0006914; GO:0070301; GO:0006954; GO:0003729; GO:0005739; GO:0007005; GO:0060548; GO:2001237; GO:0043524; GO:0032091; GO:0005634; GO:0008233; GO:0004601; GO:2000277; GO:0042803; GO:0050821; GO:0006508; GO:0060765; GO:0050727; GO:0043523; GO:0007338 autophagy; cellular response to hydrogen peroxide; inflammatory response; mRNA binding; mitochondrion; mitochondrion organization; negative regulation of cell death; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of neuron apoptotic process; negative regulation of protein binding; nucleus; peptidase activity; peroxidase activity; positive regulation of oxidative phosphorylation uncoupler activity; protein homodimerization activity; protein stabilization; proteolysis; regulation of androgen receptor signaling pathway; regulation of inflammatory response; regulation of neuron apoptotic process; single fertilization IPR006287; IPR002818; Protein DJ-1 (EC 3.4.-.-) (Parkinson disease protein 7 homolog) PARK7 Bos taurus (Bovine) TR42921_c3_g1_i2 Q5E946 PARK7_BOVIN 1.00E-68 GO:0006914; GO:0070301; GO:0006954; GO:0003729; GO:0005739; GO:0007005; GO:0060548; GO:2001237; GO:0043524; GO:0032091; GO:0005634; GO:0008233; GO:0004601; GO:2000277; GO:0042803; GO:0050821; GO:0006508; GO:0060765; GO:0050727; GO:0043523; GO:0007338 autophagy; cellular response to hydrogen peroxide; inflammatory response; mRNA binding; mitochondrion; mitochondrion organization; negative regulation of cell death; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of neuron apoptotic process; negative regulation of protein binding; nucleus; peptidase activity; peroxidase activity; positive regulation of oxidative phosphorylation uncoupler activity; protein homodimerization activity; protein stabilization; proteolysis; regulation of androgen receptor signaling pathway; regulation of inflammatory response; regulation of neuron apoptotic process; single fertilization IPR006287; IPR002818; Protein DJ-1 (EC 3.4.-.-) (Parkinson disease protein 7 homolog) PARK7 Bos taurus (Bovine) TR42921_c3_g1_i3 Q10356 YDB3_SCHPO 6.00E-19 GO:0005829; GO:0005634 cytosol; nucleus IPR002818; Uncharacterized protein C22E12.03c SPAC22E12.03c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42925_c0_g2_i1 Q16222 UAP1_HUMAN 0 GO:0006048; GO:0003977; GO:0030246; GO:0005829; GO:0006488; GO:0005634; GO:0005886; GO:0043687; GO:0018279 UDP-N-acetylglucosamine biosynthetic process; UDP-N-acetylglucosamine diphosphorylase activity; carbohydrate binding; cytosol; dolichol-linked oligosaccharide biosynthetic process; nucleus; plasma membrane; post-translational protein modification; protein N-linked glycosylation via asparagine IPR002618; Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1. UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Sperm-associated antigen 2) [Includes: UDP-N-acetylgalactosamine pyrophosphorylase (EC 2.7.7.83) (AGX-1); UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (AGX-2)] UAP1 SPAG2 Homo sapiens (Human) TR42925_c0_g2_i3 Q9C5I1 USP_ARATH 3.00E-20 GO:0052573; GO:0033356; GO:0006011; GO:0046398; GO:0010491; GO:0017103; GO:0003983; GO:0047338; GO:0005829; GO:0047350; GO:0009226; GO:0009555; GO:0090406; GO:0046686 UDP-D-galactose metabolic process; UDP-L-arabinose metabolic process; UDP-glucose metabolic process; UDP-glucuronate metabolic process; UTP:arabinose-1-phosphate uridylyltransferase activity; UTP:galactose-1-phosphate uridylyltransferase activity; UTP:glucose-1-phosphate uridylyltransferase activity; UTP:xylose-1-phosphate uridylyltransferase activity; cytosol; glucuronate-1-phosphate uridylyltransferase activity; nucleotide-sugar biosynthetic process; pollen development; pollen tube; response to cadmium ion IPR002618; UDP-sugar pyrophosphorylase (AtUSP) (EC 2.7.7.64) USP At5g52560 F6N7.4 Arabidopsis thaliana (Mouse-ear cress) TR42925_c0_g2_i4 Q5HM59 URTF_STAEQ 2.00E-62 GO:0016779 nucleotidyltransferase activity IPR002618; Probable uridylyltransferase SERP1770 (EC 2.7.7.-) SERP1770 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) TR42925_c0_g2_i7 P78811 UGPA1_SCHPO 7.00E-13 GO:0006011; GO:0003983; GO:0005829; GO:0046872; GO:0005634 UDP-glucose metabolic process; UTP:glucose-1-phosphate uridylyltransferase activity; cytosol; metal ion binding; nucleus IPR002618; IPR016267; Probable UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) fuy1 SPCC1322.04 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42925_c0_g2_i8 Q16222 UAP1_HUMAN 5.00E-39 GO:0006048; GO:0003977; GO:0030246; GO:0005829; GO:0006488; GO:0005634; GO:0005886; GO:0043687; GO:0018279 UDP-N-acetylglucosamine biosynthetic process; UDP-N-acetylglucosamine diphosphorylase activity; carbohydrate binding; cytosol; dolichol-linked oligosaccharide biosynthetic process; nucleus; plasma membrane; post-translational protein modification; protein N-linked glycosylation via asparagine IPR002618; Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1. UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Sperm-associated antigen 2) [Includes: UDP-N-acetylgalactosamine pyrophosphorylase (EC 2.7.7.83) (AGX-1); UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (AGX-2)] UAP1 SPAG2 Homo sapiens (Human) TR42927_c2_g1_i2 Q7ZYR8 RSRC2_XENLA 2.00E-20 IPR026760; IPR028124; Arginine/serine-rich coiled-coil protein 2 rsrc2 Xenopus laevis (African clawed frog) TR42927_c2_g1_i3 Q7ZYR8 RSRC2_XENLA 2.00E-20 IPR026760; IPR028124; Arginine/serine-rich coiled-coil protein 2 rsrc2 Xenopus laevis (African clawed frog) TR42931_c0_g2_i1 P13648 LMNA_CHICK 2.00E-12 GO:0005882; GO:0005634; GO:0005198 intermediate filament; nucleus; structural molecule activity IPR001664; IPR018039; IPR001322; Lamin-A LMNA Gallus gallus (Chicken) TR42931_c0_g3_i2 P47819 GFAP_RAT 1.00E-06 GO:0060020; GO:0014002; GO:0097449; GO:0044297; GO:0005737; GO:0030198; GO:0005178; GO:0005882; GO:0045109; GO:0060291; GO:0016020; GO:0010977; GO:0031102; GO:0010625; GO:0060252; GO:0051580; GO:0009611; GO:0005200 Bergmann glial cell differentiation; astrocyte development; astrocyte projection; cell body; cytoplasm; extracellular matrix organization; integrin binding; intermediate filament; intermediate filament organization; long-term synaptic potentiation; membrane; negative regulation of neuron projection development; neuron projection regeneration; positive regulation of Schwann cell proliferation; positive regulation of glial cell proliferation; regulation of neurotransmitter uptake; response to wounding; structural constituent of cytoskeleton IPR027701; IPR001664; IPR018039; Glial fibrillary acidic protein (GFAP) Gfap Rattus norvegicus (Rat) TR42931_c0_g4_i1 P08928 LAM0_DROME 1.00E-41 GO:0008344; GO:0007569; GO:0007417; GO:0005813; GO:0051297; GO:0040003; GO:0006342; GO:0001745; GO:0048546; GO:0035262; GO:0005638; GO:0046331; GO:0005811; GO:0005875; GO:0007084; GO:0072686; GO:0005635; GO:0071763; GO:0007097; GO:0031081; GO:0090435; GO:0005198; GO:0007430 "adult locomotory behavior; cell aging; central nervous system development; centrosome; centrosome organization; chitin-based cuticle development; chromatin silencing; compound eye morphogenesis; digestive tract morphogenesis; gonad morphogenesis; lamin filament; lateral inhibition; lipid particle; microtubule associated complex; mitotic nuclear envelope reassembly; mitotic spindle; nuclear envelope; nuclear membrane organization; nuclear migration; nuclear pore distribution; protein localization to nuclear envelope; structural molecule activity; terminal branching, open tracheal system" IPR001664; IPR001322; Lamin Dm0 Lam CG6944 Drosophila melanogaster (Fruit fly) TR42933_c1_g1_i1 O43312 MTSS1_HUMAN 1.00E-105 GO:0015629; GO:0030036; GO:0030041; GO:0003785; GO:0007155; GO:0006928; GO:0071498; GO:0030139; GO:2001013; GO:0046847; GO:0072102; GO:0030035; GO:0050680; GO:0072160; GO:0001726; GO:0007169 Itself; Q60598; P42858 actin cytoskeleton; actin cytoskeleton organization; actin filament polymerization; actin monomer binding; cell adhesion; cellular component movement; cellular response to fluid shear stress; endocytic vesicle; epithelial cell proliferation involved in renal tubule morphogenesis; filopodium assembly; glomerulus morphogenesis; microspike assembly; negative regulation of epithelial cell proliferation; nephron tubule epithelial cell differentiation; ruffle; transmembrane receptor protein tyrosine kinase signaling pathway IPR013606; IPR027682; IPR003124; Metastasis suppressor protein 1 (Metastasis suppressor YGL-1) (Missing in metastasis protein) MTSS1 KIAA0429 MIM Homo sapiens (Human) TR42933_c1_g1_i10 O43312 MTSS1_HUMAN 8.00E-106 GO:0015629; GO:0030036; GO:0030041; GO:0003785; GO:0007155; GO:0006928; GO:0071498; GO:0030139; GO:2001013; GO:0046847; GO:0072102; GO:0030035; GO:0050680; GO:0072160; GO:0001726; GO:0007169 Itself; Q60598; P42858 actin cytoskeleton; actin cytoskeleton organization; actin filament polymerization; actin monomer binding; cell adhesion; cellular component movement; cellular response to fluid shear stress; endocytic vesicle; epithelial cell proliferation involved in renal tubule morphogenesis; filopodium assembly; glomerulus morphogenesis; microspike assembly; negative regulation of epithelial cell proliferation; nephron tubule epithelial cell differentiation; ruffle; transmembrane receptor protein tyrosine kinase signaling pathway IPR013606; IPR027682; IPR003124; Metastasis suppressor protein 1 (Metastasis suppressor YGL-1) (Missing in metastasis protein) MTSS1 KIAA0429 MIM Homo sapiens (Human) TR42933_c1_g1_i2 Q60437 BAIP2_CRIGR 1.00E-11 GO:0051764; GO:0051017; GO:0005856; GO:0005829; GO:0030175; GO:0046847; GO:0016020; GO:0070064; GO:0032956; GO:0008360; GO:0009617; GO:0001726; GO:0007165 Q9NZQ3 actin crosslink formation; actin filament bundle assembly; cytoskeleton; cytosol; filopodium; filopodium assembly; membrane; proline-rich region binding; regulation of actin cytoskeleton organization; regulation of cell shape; response to bacterium; ruffle; signal transduction IPR027681; IPR013606; IPR001452; Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate) (p58/p53) BAIAP2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR42933_c1_g1_i5 O43312 MTSS1_HUMAN 8.00E-106 GO:0015629; GO:0030036; GO:0030041; GO:0003785; GO:0007155; GO:0006928; GO:0071498; GO:0030139; GO:2001013; GO:0046847; GO:0072102; GO:0030035; GO:0050680; GO:0072160; GO:0001726; GO:0007169 Itself; Q60598; P42858 actin cytoskeleton; actin cytoskeleton organization; actin filament polymerization; actin monomer binding; cell adhesion; cellular component movement; cellular response to fluid shear stress; endocytic vesicle; epithelial cell proliferation involved in renal tubule morphogenesis; filopodium assembly; glomerulus morphogenesis; microspike assembly; negative regulation of epithelial cell proliferation; nephron tubule epithelial cell differentiation; ruffle; transmembrane receptor protein tyrosine kinase signaling pathway IPR013606; IPR027682; IPR003124; Metastasis suppressor protein 1 (Metastasis suppressor YGL-1) (Missing in metastasis protein) MTSS1 KIAA0429 MIM Homo sapiens (Human) TR42933_c1_g1_i9 Q60437 BAIP2_CRIGR 1.00E-11 GO:0051764; GO:0051017; GO:0005856; GO:0005829; GO:0030175; GO:0046847; GO:0016020; GO:0070064; GO:0032956; GO:0008360; GO:0009617; GO:0001726; GO:0007165 Q9NZQ3 actin crosslink formation; actin filament bundle assembly; cytoskeleton; cytosol; filopodium; filopodium assembly; membrane; proline-rich region binding; regulation of actin cytoskeleton organization; regulation of cell shape; response to bacterium; ruffle; signal transduction IPR027681; IPR013606; IPR001452; Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate) (p58/p53) BAIAP2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR42936_c0_g1_i1 P54846 NRL_MOUSE 6.00E-17 GO:0005634; GO:0045872; GO:0045944; GO:0046548; GO:0043565; GO:0003700; GO:0006351 "nucleus; positive regulation of rhodopsin gene expression; positive regulation of transcription from RNA polymerase II promoter; retinal rod cell development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; IPR004826; IPR013592; IPR008917; IPR024874; Neural retina-specific leucine zipper protein (NRL) Nrl Mus musculus (Mouse) TR42937_c0_g1_i1 Q23551 UNC22_CAEEL 5.00E-171 GO:0031672; GO:0005524; GO:0046872; GO:0004674 A band; ATP binding; metal ion binding; protein serine/threonine kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans TR42937_c0_g1_i2 Q14896 MYPC3_HUMAN 5.00E-38 GO:0001671; GO:0014705; GO:0060048; GO:0007155; GO:0005829; GO:0046872; GO:0030049; GO:0017022; GO:0031034; GO:0002027; GO:0032971; GO:0006942; GO:0045214; GO:0005863; GO:0008307; GO:0031432; GO:0055010 Itself ATPase activator activity; C zone; cardiac muscle contraction; cell adhesion; cytosol; metal ion binding; muscle filament sliding; myosin binding; myosin filament assembly; regulation of heart rate; regulation of muscle filament sliding; regulation of striated muscle contraction; sarcomere organization; striated muscle myosin thick filament; structural constituent of muscle; titin binding; ventricular cardiac muscle tissue morphogenesis IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; "Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)" MYBPC3 Homo sapiens (Human) TR42938_c0_g1_i1 Q99570 PI3R4_HUMAN 0 GO:0005524; GO:0005829; GO:0045087; GO:0008286; GO:0005770; GO:0006661; GO:0004672; GO:0004674; GO:0044281; GO:0034162 ATP binding; cytosol; innate immune response; insulin receptor signaling pathway; late endosome; phosphatidylinositol biosynthetic process; protein kinase activity; protein serine/threonine kinase activity; small molecule metabolic process; toll-like receptor 9 signaling pathway IPR011989; IPR016024; IPR021133; IPR011009; IPR000719; IPR008271; IPR015943; IPR001680; IPR019775; IPR017986; Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) PIK3R4 Homo sapiens (Human) TR42938_c0_g1_i2 Q99570 PI3R4_HUMAN 0 GO:0005524; GO:0005829; GO:0045087; GO:0008286; GO:0005770; GO:0006661; GO:0004672; GO:0004674; GO:0044281; GO:0034162 ATP binding; cytosol; innate immune response; insulin receptor signaling pathway; late endosome; phosphatidylinositol biosynthetic process; protein kinase activity; protein serine/threonine kinase activity; small molecule metabolic process; toll-like receptor 9 signaling pathway IPR011989; IPR016024; IPR021133; IPR011009; IPR000719; IPR008271; IPR015943; IPR001680; IPR019775; IPR017986; Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) PIK3R4 Homo sapiens (Human) TR42939_c0_g1_i1 Q00963 SPTCB_DROME 4.00E-128 GO:0003779; GO:0051693; GO:0030506; GO:0016327; GO:0030424; GO:0016199; GO:0045169; GO:0045478; GO:0016328; GO:0005811; GO:0042062; GO:0048790; GO:0008017; GO:0007026; GO:0031594; GO:0007274; GO:0005546; GO:0072499; GO:0007009; GO:0008091; GO:0045170; GO:0030721; GO:0005200 "actin binding; actin filament capping; ankyrin binding; apicolateral plasma membrane; axon; axon midline choice point recognition; fusome; fusome organization; lateral plasma membrane; lipid particle; long-term strengthening of neuromuscular junction; maintenance of presynaptic active zone structure; microtubule binding; negative regulation of microtubule depolymerization; neuromuscular junction; neuromuscular synaptic transmission; phosphatidylinositol-4,5-bisphosphate binding; photoreceptor cell axon guidance; plasma membrane organization; spectrin; spectrosome; spectrosome organization; structural constituent of cytoskeleton" IPR001589; IPR001715; IPR001605; IPR011993; IPR001849; IPR018159; IPR016343; IPR002017; Spectrin beta chain beta-Spec Spec-b CG5870 Drosophila melanogaster (Fruit fly) TR42939_c0_g1_i2 P13395 SPTCA_DROME 0 GO:0005794; GO:0003779; GO:0051693; GO:0016199; GO:0016323; GO:0005509; GO:0007417; GO:0045169; GO:0045478; GO:0030727; GO:0007294; GO:0005811; GO:0042062; GO:0048790; GO:0008017; GO:0007026; GO:0031594; GO:0007274; GO:0007308; GO:0030707; GO:0007009; GO:0008360; GO:0008091; GO:0045170; GO:0030721 Golgi apparatus; actin binding; actin filament capping; axon midline choice point recognition; basolateral plasma membrane; calcium ion binding; central nervous system development; fusome; fusome organization; germarium-derived female germ-line cyst formation; germarium-derived oocyte fate determination; lipid particle; long-term strengthening of neuromuscular junction; maintenance of presynaptic active zone structure; microtubule binding; negative regulation of microtubule depolymerization; neuromuscular junction; neuromuscular synaptic transmission; oocyte construction; ovarian follicle cell development; plasma membrane organization; regulation of cell shape; spectrin; spectrosome; spectrosome organization IPR011992; IPR014837; IPR018247; IPR002048; IPR001452; IPR018159; IPR013315; IPR002017; Spectrin alpha chain alpha-Spec SPEC-A CG1977 Drosophila melanogaster (Fruit fly) TR42939_c0_g1_i3 Q62261 SPTB2_MOUSE 7.00E-140 GO:0043001; GO:0031430; GO:0007184; GO:0051693; GO:0030673; GO:0007182; GO:0032437; GO:0071709; GO:0000281; GO:0005730; GO:0005634; GO:0005543; GO:0072661; GO:0008091; GO:0005200 Golgi to plasma membrane protein transport; M band; SMAD protein import into nucleus; actin filament capping; axolemma; common-partner SMAD protein phosphorylation; cuticular plate; membrane assembly; mitotic cytokinesis; nucleolus; nucleus; phospholipid binding; protein targeting to plasma membrane; spectrin; structural constituent of cytoskeleton IPR001589; IPR001715; IPR001605; IPR011993; IPR001849; IPR018159; IPR016343; IPR002017; "Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Embryonic liver fodrin) (Fodrin beta chain)" Sptbn1 Elf Spnb-2 Spnb2 Sptb2 Mus musculus (Mouse) TR42939_c0_g1_i4 Q5BBL4 HSE1_EMENI 7.00E-10 GO:0033565; GO:0030479; GO:0051015; GO:0005829; GO:0010008; GO:0030010; GO:0001411; GO:0006886; GO:0045324 ESCRT-0 complex; actin cortical patch; actin filament binding; cytosol; endosome membrane; establishment of cell polarity; hyphal tip; intracellular protein transport; late endosome to vacuole transport IPR008942; IPR001452; IPR027423; IPR013315; IPR003903; IPR002014; IPR018205; Class E vacuolar protein-sorting machinery protein hse1 hse1 AN2066 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR42939_c0_g2_i4 Q13813 SPTN1_HUMAN 0 GO:0030018; GO:0003779; GO:0051693; GO:0007411; GO:0005509; GO:0006921; GO:0032437; GO:0005829; GO:0005916; GO:0043231; GO:0016328; GO:0016020; GO:0015630; GO:0008091; GO:0005200 Q9UI08; O15287; P40692; Q01082 Z disc; actin binding; actin filament capping; axon guidance; calcium ion binding; cellular component disassembly involved in execution phase of apoptosis; cuticular plate; cytosol; fascia adherens; intracellular membrane-bounded organelle; lateral plasma membrane; membrane; microtubule cytoskeleton; spectrin; structural constituent of cytoskeleton IPR011992; IPR014837; IPR018247; IPR002048; IPR001452; IPR018159; IPR013315; IPR002017; "Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)" SPTAN1 NEAS SPTA2 Homo sapiens (Human) TR42939_c0_g2_i5 Q91ZU6 DYST_MOUSE 2.00E-12 GO:0031673; GO:0030018; GO:0015629; GO:0030424; GO:0007409; GO:0005509; GO:0007155; GO:0005938; GO:0007050; GO:0016023; GO:0031122; GO:0005789; GO:0005925; GO:0030056; GO:0016021; GO:0014704; GO:0005882; GO:0045104; GO:0009898; GO:0046907; GO:0015630; GO:0035371; GO:0051010; GO:0060053; GO:0005635; GO:0005634; GO:0097038; GO:0042803; GO:0031110; GO:0008090; GO:0042383; GO:0001725 P21807 H zone; Z disc; actin cytoskeleton; axon; axonogenesis; calcium ion binding; cell adhesion; cell cortex; cell cycle arrest; cytoplasmic membrane-bounded vesicle; cytoplasmic microtubule organization; endoplasmic reticulum membrane; focal adhesion; hemidesmosome; integral to membrane; intercalated disc; intermediate filament; intermediate filament cytoskeleton organization; internal side of plasma membrane; intracellular transport; microtubule cytoskeleton; microtubule plus end; microtubule plus-end binding; neurofilament cytoskeleton; nuclear envelope; nucleus; perinuclear endoplasmic reticulum; protein homodimerization activity; regulation of microtubule polymerization or depolymerization; retrograde axon cargo transport; sarcolemma; stress fiber IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; IPR003108; IPR001101; IPR018159; IPR002017; Dystonin (Bullous pemphigoid antigen 1) (BPA) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) (Microtubule actin cross-linking factor 2) Dst Bpag1 Macf2 Mus musculus (Mouse) TR42939_c0_g2_i6 Q13813 SPTN1_HUMAN 0 GO:0030018; GO:0003779; GO:0051693; GO:0007411; GO:0005509; GO:0006921; GO:0032437; GO:0005829; GO:0005916; GO:0043231; GO:0016328; GO:0016020; GO:0015630; GO:0008091; GO:0005200 Q9UI08; O15287; P40692; Q01082 Z disc; actin binding; actin filament capping; axon guidance; calcium ion binding; cellular component disassembly involved in execution phase of apoptosis; cuticular plate; cytosol; fascia adherens; intracellular membrane-bounded organelle; lateral plasma membrane; membrane; microtubule cytoskeleton; spectrin; structural constituent of cytoskeleton IPR011992; IPR014837; IPR018247; IPR002048; IPR001452; IPR018159; IPR013315; IPR002017; "Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)" SPTAN1 NEAS SPTA2 Homo sapiens (Human) TR42942_c0_g1_i2 Q28653 2A5D_RABIT 0 GO:0005634; GO:0000159; GO:0008601; GO:0007165 nucleus; protein phosphatase type 2A complex; protein phosphatase type 2A regulator activity; signal transduction IPR016024; IPR002554; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) PPP2R5D Oryctolagus cuniculus (Rabbit) TR42942_c0_g1_i4 Q14738 2A5D_HUMAN 0 GO:0002755; GO:0035666; GO:0005829; GO:0006112; GO:0006096; GO:0045087; GO:0007399; GO:0048011; GO:0005654; GO:0000159; GO:0008601; GO:0004722; GO:0044281; GO:0051403; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124 O08785; Q13136; P30153; P30154 MyD88-dependent toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; cytosol; energy reserve metabolic process; glycolysis; innate immune response; nervous system development; neurotrophin TRK receptor signaling pathway; nucleoplasm; protein phosphatase type 2A complex; protein phosphatase type 2A regulator activity; protein serine/threonine phosphatase activity; small molecule metabolic process; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor TLR1:TLR2 signaling pathway; toll-like receptor TLR6:TLR2 signaling pathway IPR016024; IPR002554; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) PPP2R5D Homo sapiens (Human) TR42943_c0_g1_i1 Q9H2X6 HIPK2_HUMAN 0 GO:0005524; GO:0006978; GO:0016605; GO:0030578; GO:0001102; GO:0001105; GO:0060395; GO:0007628; GO:0009952; GO:0071456; GO:0005813; GO:0005737; GO:0048596; GO:0060059; GO:0030218; GO:0001654; GO:0042771; GO:0061072; GO:0060235; GO:0019048; GO:0030514; GO:0043524; GO:0000122; GO:0030182; GO:0016604; GO:0031965; GO:0018105; GO:0018107; GO:0043388; GO:0046330; GO:0045766; GO:0008284; GO:0032092; GO:0051091; GO:0045944; GO:0030511; GO:0004674; GO:0051726; GO:0010842; GO:0007224; GO:0003714; GO:0007179; GO:0046790; GO:0050882 P61962; Q09472; P51608; Q01196; P63279 "ATP binding; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; PML body; PML body organization; RNA polymerase II activating transcription factor binding; RNA polymerase II transcription coactivator activity; SMAD protein signal transduction; adult walking behavior; anterior/posterior pattern specification; cellular response to hypoxia; centrosome; cytoplasm; embryonic camera-type eye morphogenesis; embryonic retina morphogenesis in camera-type eye; erythrocyte differentiation; eye development; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; iris morphogenesis; lens induction in camera-type eye; modulation by virus of host morphology or physiology; negative regulation of BMP signaling pathway; negative regulation of neuron apoptotic process; negative regulation of transcription from RNA polymerase II promoter; neuron differentiation; nuclear body; nuclear membrane; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of DNA binding; positive regulation of JNK cascade; positive regulation of angiogenesis; positive regulation of cell proliferation; positive regulation of protein binding; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor beta receptor signaling pathway; protein serine/threonine kinase activity; regulation of cell cycle; retina layer formation; smoothened signaling pathway; transcription corepressor activity; transforming growth factor beta receptor signaling pathway; virion binding; voluntary musculoskeletal movement" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) HIPK2 Homo sapiens (Human) TR42944_c0_g1_i1 Q9VXE5 PAKM_DROME 1.00E-163 GO:0005524; GO:0007030; GO:0000187; GO:0005913; GO:0001751; GO:0007010; GO:0046331; GO:0016319; GO:0045792; GO:0005886; GO:0045315; GO:0004702 P40793 ATP binding; Golgi organization; activation of MAPK activity; cell-cell adherens junction; compound eye photoreceptor cell differentiation; cytoskeleton organization; lateral inhibition; mushroom body development; negative regulation of cell size; plasma membrane; positive regulation of compound eye photoreceptor development; receptor signaling protein serine/threonine kinase activity IPR000095; IPR011009; IPR000719; IPR017441; IPR002290; Serine/threonine-protein kinase PAK mbt (EC 2.7.11.1) (Protein mushroom bodies tiny) (p21-activated kinase-related protein) mbt CG18582 Drosophila melanogaster (Fruit fly) TR42944_c1_g1_i1 Q5ZL16 WIPI3_CHICK 0 GO:0000045; GO:0005737; GO:0080025; GO:0032266 "autophagic vacuole assembly; cytoplasm; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding" IPR015943; IPR001680; IPR017986; WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat-containing protein 45B) WDR45B WIPI3 RCJMB04_8d21 Gallus gallus (Chicken) TR42944_c1_g1_i2 Q5B464 HSV2_EMENI 4.00E-48 GO:0000045; GO:0005737; GO:0030659; GO:0080025; GO:0032266; GO:0015031; GO:0005774 "autophagic vacuole assembly; cytoplasm; cytoplasmic vesicle membrane; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding; protein transport; vacuolar membrane" IPR015943; IPR001680; IPR017986; SVP1-like protein 2 hsv2 AN4666 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR42944_c1_g1_i4 Q59P11 HSV2_CANAL 2.00E-20 GO:0030659; GO:0015031; GO:0005774 cytoplasmic vesicle membrane; protein transport; vacuolar membrane IPR015943; IPR001680; IPR017986; SVP1-like protein 2 HSV2 CaO19.1793 CaO19.9359 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) TR42944_c1_g1_i5 Q5ZL16 WIPI3_CHICK 0 GO:0000045; GO:0005737; GO:0080025; GO:0032266 "autophagic vacuole assembly; cytoplasm; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding" IPR015943; IPR001680; IPR017986; WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat-containing protein 45B) WDR45B WIPI3 RCJMB04_8d21 Gallus gallus (Chicken) TR42944_c1_g1_i6 Q6NMB0 HIBC3_ARATH 4.00E-08 GO:0003860; GO:0005777; GO:0006574 3-hydroxyisobutyryl-CoA hydrolase activity; peroxisome; valine catabolic process IPR001753; Amino-acid degradation; L-valine degradation. Probable 3-hydroxyisobutyryl-CoA hydrolase 3 (EC 3.1.2.4) At2g30660 T11J7.5 Arabidopsis thaliana (Mouse-ear cress) TR42944_c1_g2_i1 Q8BH95 ECHM_MOUSE 5.00E-91 GO:0004300; GO:0006635; GO:0005759; GO:0005739 enoyl-CoA hydratase activity; fatty acid beta-oxidation; mitochondrial matrix; mitochondrion IPR001753; IPR018376; Lipid metabolism; fatty acid beta-oxidation. "Enoyl-CoA hydratase, mitochondrial (EC 4.2.1.17) (Enoyl-CoA hydratase 1) (Short-chain enoyl-CoA hydratase) (SCEH)" Echs1 Mus musculus (Mouse) TR42947_c2_g1_i1 P98093 CO3_ONCMY 1.00E-102 GO:0006957; GO:0006958; GO:0004866; GO:0005615; GO:0006954; GO:0010951 "complement activation, alternative pathway; complement activation, classical pathway; endopeptidase inhibitor activity; extracellular space; inflammatory response; negative regulation of endopeptidase activity" IPR009048; IPR011626; IPR002890; IPR011625; IPR000020; IPR018081; IPR001599; IPR019742; IPR019565; IPR001134; IPR018933; IPR008930; IPR008993; Complement C3 [Cleaved into: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2] (Fragment) c3 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR42947_c2_g1_i2 P12247 CO3_RABIT 7.00E-34 GO:0006957; GO:0006958; GO:0005615; GO:0006954 "complement activation, alternative pathway; complement activation, classical pathway; extracellular space; inflammatory response" IPR009048; IPR011626; IPR019742; IPR019565; IPR001134; IPR018933; IPR008930; IPR008993; Complement C3 alpha chain (Fragment) C3 Oryctolagus cuniculus (Rabbit) TR42947_c2_g1_i3 P98093 CO3_ONCMY 9.00E-103 GO:0006957; GO:0006958; GO:0004866; GO:0005615; GO:0006954; GO:0010951 "complement activation, alternative pathway; complement activation, classical pathway; endopeptidase inhibitor activity; extracellular space; inflammatory response; negative regulation of endopeptidase activity" IPR009048; IPR011626; IPR002890; IPR011625; IPR000020; IPR018081; IPR001599; IPR019742; IPR019565; IPR001134; IPR018933; IPR008930; IPR008993; Complement C3 [Cleaved into: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2] (Fragment) c3 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR42947_c2_g1_i4 P20742 PZP_HUMAN 4.00E-67 GO:0004866; GO:0005615; GO:0070062; GO:0007565; GO:0004867 endopeptidase inhibitor activity; extracellular space; extracellular vesicular exosome; female pregnancy; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; IPR010916; Pregnancy zone protein (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6) PZP CPAMD6 Homo sapiens (Human) TR42948_c0_g1_i1 Q54KE6 MCCA_DICDI 3.00E-41 GO:0005524; GO:0004075; GO:0006552; GO:0046872; GO:0004485; GO:0005759; GO:0005739 ATP binding; biotin carboxylase activity; leucine catabolic process; metal ion binding; methylcrotonoyl-CoA carboxylase activity; mitochondrial matrix; mitochondrion IPR011761; IPR013815; IPR013816; IPR001882; IPR011764; IPR005482; IPR000089; IPR005481; IPR005479; IPR016185; IPR011054; IPR011053; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3. "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha)" mccA mccc1 DDB_G0287377 Dictyostelium discoideum (Slime mold) TR42948_c0_g2_i5 Q5I0C3 MCCA_RAT 0 GO:0005524; GO:0004075; GO:0006552; GO:0046872; GO:0004485; GO:0005759 ATP binding; biotin carboxylase activity; leucine catabolic process; metal ion binding; methylcrotonoyl-CoA carboxylase activity; mitochondrial matrix IPR011761; IPR013815; IPR013816; IPR001882; IPR011764; IPR005482; IPR000089; IPR005481; IPR005479; IPR016185; IPR011054; IPR011053; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3. "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha)" Mccc1 Mcca Rattus norvegicus (Rat) TR42948_c0_g2_i9 P20054 PYR1_DICDI 4.00E-07 GO:0044205; GO:0006207; GO:0005524; GO:0016597; GO:0004070; GO:0070409; GO:0004088; GO:0005737; GO:0004151; GO:0006543; GO:0006541; GO:0046872 'de novo' UMP biosynthetic process; 'de novo' pyrimidine nucleobase biosynthetic process; ATP binding; amino acid binding; aspartate carbamoyltransferase activity; carbamoyl phosphate biosynthetic process; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; cytoplasm; dihydroorotase activity; glutamine catabolic process; glutamine metabolic process; metal ion binding IPR006680; IPR006132; IPR006130; IPR002082; IPR006131; IPR011761; IPR013815; IPR013816; IPR006275; IPR005481; IPR005480; IPR006274; IPR002474; IPR005479; IPR005483; IPR002195; IPR017926; IPR011059; IPR011607; IPR016185; Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. Protein PYR1-3 [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] pyr1-3 DDB_G0276335 Dictyostelium discoideum (Slime mold) TR42948_c0_g3_i1 Q99MR8 MCCA_MOUSE 7.00E-49 GO:0005524; GO:0004075; GO:0006552; GO:0046872; GO:0004485; GO:0005743; GO:0005759 ATP binding; biotin carboxylase activity; leucine catabolic process; metal ion binding; methylcrotonoyl-CoA carboxylase activity; mitochondrial inner membrane; mitochondrial matrix IPR011761; IPR013815; IPR013816; IPR001882; IPR011764; IPR005482; IPR000089; IPR005481; IPR005479; IPR016185; IPR011054; IPR011053; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3. "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha)" Mccc1 Mcca Mus musculus (Mouse) TR42949_c1_g1_i1 P53689 ACT_PHARH 2.00E-167 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; Actin Phaffia rhodozyma (Yeast) (Xanthophyllomyces dendrorhous) TR42952_c1_g1_i1 Q3ZBP3 RBMS1_BOVIN 9.00E-68 GO:0003677; GO:0006260; GO:0003723; GO:0000166; GO:0005634 DNA binding; DNA replication; RNA binding; nucleotide binding; nucleus IPR002343; IPR012677; IPR000504; "RNA-binding motif, single-stranded-interacting protein 1" RBMS1 Bos taurus (Bovine) TR42953_c1_g3_i1 Q9HCK4 ROBO2_HUMAN 4.00E-176 GO:0061364; GO:0030673; GO:0008046; GO:0016199; GO:0009986; GO:0032870; GO:0007156; GO:0042802; GO:0016021; GO:0001656; GO:0050925; GO:0051964; GO:0021891; GO:0050772; GO:0031290; GO:0001657 apoptotic process involved in luteolysis; axolemma; axon guidance receptor activity; axon midline choice point recognition; cell surface; cellular response to hormone stimulus; homophilic cell adhesion; identical protein binding; integral to membrane; metanephros development; negative regulation of negative chemotaxis; negative regulation of synapse assembly; olfactory bulb interneuron development; positive regulation of axonogenesis; retinal ganglion cell axon guidance; ureteric bud development IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; Roundabout homolog 2 ROBO2 KIAA1568 Homo sapiens (Human) TR42955_c0_g1_i1 Q92630 DYRK2_HUMAN 0 GO:0005524; GO:0005737; GO:0042771; GO:0000287; GO:0030145; GO:0051534; GO:0005634; GO:0045725; GO:0004674; GO:0004712; GO:0004713; GO:0030529; GO:0007224; GO:0043130; GO:0000151 Q9NR20 ATP binding; cytoplasm; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; magnesium ion binding; manganese ion binding; negative regulation of NFAT protein import into nucleus; nucleus; positive regulation of glycogen biosynthetic process; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; ribonucleoprotein complex; smoothened signaling pathway; ubiquitin binding; ubiquitin ligase complex IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) DYRK2 Homo sapiens (Human) TR42957_c0_g1_i1 Q9UH65 SWP70_HUMAN 3.00E-07 GO:0005524; GO:0003677; GO:0005509; GO:0005737; GO:0045190; GO:0030027; GO:0005634; GO:0005543; GO:0005886 ATP binding; DNA binding; calcium ion binding; cytoplasm; isotype switching; lamellipodium; nucleus; phospholipid binding; plasma membrane IPR002048; IPR011993; IPR001849; Switch-associated protein 70 (SWAP-70) SWAP70 KIAA0640 HSPC321 Homo sapiens (Human) TR42957_c0_g1_i2 Q6A028 SWP70_MOUSE 5.00E-07 GO:0005524; GO:0003677; GO:0005737; GO:0045190; GO:0030027; GO:0005634; GO:0005543; GO:0005886 Q61738-6 ATP binding; DNA binding; cytoplasm; isotype switching; lamellipodium; nucleus; phospholipid binding; plasma membrane IPR011993; IPR001849; Switch-associated protein 70 (SWAP-70) Swap70 Kiaa0640 Mus musculus (Mouse) TR42958_c0_g1_i1 Q10473 GALT1_RAT 1.00E-140 GO:0032580; GO:0005576; GO:0016021; GO:0030145; GO:0048471; GO:0004653; GO:0006493; GO:0018242; GO:0018243 Golgi cisterna membrane; extracellular region; integral to membrane; manganese ion binding; perinuclear region of cytoplasm; polypeptide N-acetylgalactosaminyltransferase activity; protein O-linked glycosylation; protein O-linked glycosylation via serine; protein O-linked glycosylation via threonine IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 1 (EC 2.4.1.41) (Polypeptide GalNAc transferase 1) (GalNAc-T1) (pp-GaNTase 1) (Protein-UDP acetylgalactosaminyltransferase 1) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 1 soluble form] Galnt1 Rattus norvegicus (Rat) TR42958_c0_g1_i2 Q10471 GALT2_HUMAN 0 GO:0032580; GO:0005795; GO:0016266; GO:0005576; GO:0002378; GO:0030173; GO:0030145; GO:0048471; GO:0004653; GO:0043687; GO:0018242; GO:0018243 Golgi cisterna membrane; Golgi stack; O-glycan processing; extracellular region; immunoglobulin biosynthetic process; integral to Golgi membrane; manganese ion binding; perinuclear region of cytoplasm; polypeptide N-acetylgalactosaminyltransferase activity; post-translational protein modification; protein O-linked glycosylation via serine; protein O-linked glycosylation via threonine IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 2 (EC 2.4.1.41) (Polypeptide GalNAc transferase 2) (GalNAc-T2) (pp-GaNTase 2) (Protein-UDP acetylgalactosaminyltransferase 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form] GALNT2 Homo sapiens (Human) TR42958_c0_g1_i3 Q8I136 GALT4_CAEEL 6.00E-170 GO:0000139; GO:0016021; GO:0004653; GO:0018243 Golgi membrane; integral to membrane; polypeptide N-acetylgalactosaminyltransferase activity; protein O-linked glycosylation via threonine IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 4 (pp-GaNTase 4) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 4) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4) gly-4 Y116F11B.12 Caenorhabditis elegans TR42959_c0_g1_i2 P31478 VATF_MANSE 3.00E-57 GO:0015991; GO:0046961; GO:0033180 "ATP hydrolysis coupled proton transport; proton-transporting ATPase activity, rotational mechanism; proton-transporting V-type ATPase, V1 domain" IPR008218; IPR005772; V-type proton ATPase subunit F (V-ATPase subunit F) (V-ATPase 14 kDa subunit) (Vacuolar proton pump subunit F) VHA14 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) TR42959_c2_g2_i1 Q9W552 VPS26_DROME 9.00E-164 GO:0016055; GO:0005737; GO:0006886; GO:0030111; GO:0030904; GO:0007034 Wnt receptor signaling pathway; cytoplasm; intracellular protein transport; regulation of Wnt receptor signaling pathway; retromer complex; vacuolar transport IPR005377; Vacuolar protein sorting-associated protein 26 (VPS26 protein homolog) Vps26 CG14804 Drosophila melanogaster (Fruit fly) TR42959_c2_g2_i2 Q6DH23 V26BL_DANRE 1.00E-173 GO:0005737; GO:0015031; GO:0030904; GO:0007034 cytoplasm; protein transport; retromer complex; vacuolar transport IPR005377; Vacuolar protein sorting-associated protein 26B-like (Vesicle protein sorting 26B-like) vps26bl zgc:92676 Danio rerio (Zebrafish) (Brachydanio rerio) TR42959_c2_g2_i4 Q6DH23 V26BL_DANRE 1.00E-173 GO:0005737; GO:0015031; GO:0030904; GO:0007034 cytoplasm; protein transport; retromer complex; vacuolar transport IPR005377; Vacuolar protein sorting-associated protein 26B-like (Vesicle protein sorting 26B-like) vps26bl zgc:92676 Danio rerio (Zebrafish) (Brachydanio rerio) TR4296_c1_g1_i1 Q497B2 TM45B_RAT 1.00E-15 GO:0016021 integral to membrane IPR006904; Transmembrane protein 45B Tmem45b Rattus norvegicus (Rat) TR42961_c1_g2_i4 P70206 PLXA1_MOUSE 7.00E-92 GO:0060666; GO:0016021; GO:0005622; GO:0005886; GO:0014910; GO:0017154 dichotomous subdivision of terminal units involved in salivary gland branching; integral to membrane; intracellular; plasma membrane; regulation of smooth muscle cell migration; semaphorin receptor activity IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-A1 (Plex 1) (Plexin-1) Plxna1 Kiaa4053 Mus musculus (Mouse) TR42961_c1_g2_i6 Q8CJH3 PLXB1_MOUSE 2.00E-62 GO:0005887; GO:0005622; GO:0033689; GO:0048812; GO:0043931; GO:0032321; GO:0050772; GO:0014068; GO:0008360; GO:0051493; GO:0017154; GO:0002116; GO:1900220 Q68FM7; Q8R4H2 integral to plasma membrane; intracellular; negative regulation of osteoblast proliferation; neuron projection morphogenesis; ossification involved in bone maturation; positive regulation of Rho GTPase activity; positive regulation of axonogenesis; positive regulation of phosphatidylinositol 3-kinase cascade; regulation of cell shape; regulation of cytoskeleton organization; semaphorin receptor activity; semaphorin receptor complex; semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis IPR013783; IPR014756; IPR002909; IPR016201; IPR013548; IPR002165; IPR008936; IPR001627; IPR015943; Plexin-B1 Plxnb1 Kiaa0407 Mus musculus (Mouse) TR42962_c0_g2_i1 Q9YGP6 SLBP2_XENLA 4.00E-17 GO:0005737; GO:0003729; GO:0006417 cytoplasm; mRNA binding; regulation of translation IPR026502; Oocyte-specific histone RNA stem-loop-binding protein 2 slbp2 Xenopus laevis (African clawed frog) TR42962_c0_g4_i1 P97440 SLBP_MOUSE 5.00E-18 GO:0005737; GO:0006398; GO:0071204; GO:0071207; GO:0003729; GO:0051028; GO:0033260 cytoplasm; histone mRNA 3'-end processing; histone pre-mRNA 3'end processing complex; histone pre-mRNA stem-loop binding; mRNA binding; mRNA transport; nuclear cell cycle DNA replication IPR026502; Histone RNA hairpin-binding protein (Histone stem-loop-binding protein) Slbp Hbp Mus musculus (Mouse) TR42963_c0_g1_i1 Q5R664 COPB2_PONAB 0 GO:0030663; GO:0006886; GO:0030117; GO:0005198; GO:0016192 COPI-coated vesicle membrane; intracellular protein transport; membrane coat; structural molecule activity; vesicle-mediated transport IPR006692; IPR016453; IPR020472; IPR015943; IPR001680; IPR017986; Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) COPB2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42963_c0_g1_i2 Q4RJN5 LIS1_TETNG 2.00E-30 GO:0030154; GO:0051301; GO:0006928; GO:0005737; GO:0000132; GO:0005874; GO:0005875; GO:0005815; GO:0007067; GO:0007399; GO:0006810 cell differentiation; cell division; cellular component movement; cytoplasm; establishment of mitotic spindle orientation; microtubule; microtubule associated complex; microtubule organizing center; mitosis; nervous system development; transport IPR017252; IPR020472; IPR006594; IPR013720; IPR015943; IPR001680; IPR019775; IPR017986; Lissencephaly-1 homolog pafah1b1 lis1 GSTENG00033355001 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) TR42964_c1_g1_i4 Q63HN8 RN213_HUMAN 1.00E-25 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR018957; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) TR42965_c0_g1_i1 Q9NZB2 F120A_HUMAN 5.00E-89 GO:0003723; GO:0005737; GO:0005886 RNA binding; cytoplasm; plasma membrane IPR026783; Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated Src activator) (Protein FAM120A) FAM120A C9orf10 KIAA0183 OSSA Homo sapiens (Human) TR42965_c0_g1_i3 Q9NZB2 F120A_HUMAN 9.00E-91 GO:0003723; GO:0005737; GO:0005886 RNA binding; cytoplasm; plasma membrane IPR026783; Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated Src activator) (Protein FAM120A) FAM120A C9orf10 KIAA0183 OSSA Homo sapiens (Human) TR42965_c0_g1_i4 Q9NX05 F120C_HUMAN 1.00E-77 Constitutive coactivator of PPAR-gamma-like protein 2 (Protein FAM120C) (Tumor antigen BJ-HCC-21) FAM120C CXorf17 Homo sapiens (Human) TR42966_c0_g1_i1 P98160 PGBM_HUMAN 0 GO:0005796; GO:0001525; GO:0005605; GO:0007420; GO:0005975; GO:0048738; GO:0060351; GO:0002062; GO:0030204; GO:0048704; GO:0001958; GO:0030198; GO:0005615; GO:0070062; GO:0006024; GO:0006027; GO:0042157; GO:0043202; GO:0046872; GO:0007603; GO:0005886; GO:0008104; GO:0001523 P35968 "Golgi lumen; angiogenesis; basal lamina; brain development; carbohydrate metabolic process; cardiac muscle tissue development; cartilage development involved in endochondral bone morphogenesis; chondrocyte differentiation; chondroitin sulfate metabolic process; embryonic skeletal system morphogenesis; endochondral ossification; extracellular matrix organization; extracellular space; extracellular vesicular exosome; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; lipoprotein metabolic process; lysosomal lumen; metal ion binding; phototransduction, visible light; plasma membrane; protein localization; retinoid metabolic process" IPR008985; IPR013320; IPR000742; IPR013032; IPR002049; IPR007110; IPR013783; IPR013098; IPR003598; IPR018031; IPR000034; IPR001791; IPR023415; IPR002172; IPR000082; Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] HSPG2 Homo sapiens (Human) TR42966_c0_g2_i2 Q98931 LRP8_CHICK 1.00E-30 GO:0005509; GO:0006897; GO:0016021; GO:0021517 calcium ion binding; endocytosis; integral to membrane; ventral spinal cord development IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2) (Protein LR8B) LRP8 LR8B Gallus gallus (Chicken) TR42966_c0_g2_i3 Q9NZR2 LRP1B_HUMAN 1.00E-41 GO:0005509; GO:0016021; GO:0005041; GO:0015031; GO:0006898 calcium ion binding; integral to membrane; low-density lipoprotein receptor activity; protein transport; receptor-mediated endocytosis IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) LRP1B LRPDIT Homo sapiens (Human) TR42967_c2_g2_i1 Q5S007 LRRK2_HUMAN 9.00E-06 GO:0005524; GO:0005525; GO:0034211; GO:0005096; GO:0003924; GO:0004708; GO:0000186; GO:0006914; GO:0032839; GO:0008340; GO:0035640; GO:0032473; GO:0048312; GO:0045121; GO:0034260; GO:2000173; GO:0061002; GO:0007406; GO:0014043; GO:0007528; GO:0070997; GO:0043025; GO:0018105; GO:0018107; GO:0005886; GO:0010508; GO:0060161; GO:0043068; GO:0032436; GO:0031398; GO:0046777; GO:0035564; GO:0040012; GO:0042391; GO:0006979; GO:0007264; GO:0008021; GO:0022028; GO:0005802; GO:0015631 Itself; Q9UKV8; P31749; Q8N6T3-2; Q62848; Q14155; Q16543; P60953; P30275; P53355; O00429; O00429-3; O14640-2; O14641; Q92997; Q13158; P11142; O75581; Q38SD2; P46734; P52564; O14733; P10636-8; P02687; P26038; Q13469; O60260; P30048; P61020; P61021; Q63481; P63000; Q99962; P37840; Q58A65; P31946; P62258; P61981; Q04917; P27348; P63104 ATP binding; GTP binding; GTP-dependent protein kinase activity; GTPase activator activity; GTPase activity; MAP kinase kinase activity; activation of MAPKK activity; autophagy; dendrite cytoplasm; determination of adult lifespan; exploration behavior; external side of mitochondrial outer membrane; intracellular distribution of mitochondria; membrane raft; negative regulation of GTPase activity; negative regulation of branching morphogenesis of a nerve; negative regulation of dendritic spine morphogenesis; negative regulation of neuroblast proliferation; negative regulation of neuron maturation; neuromuscular junction development; neuron death; neuronal cell body; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; plasma membrane; positive regulation of autophagy; positive regulation of dopamine receptor signaling pathway; positive regulation of programmed cell death; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; protein autophosphorylation; regulation of kidney size; regulation of locomotion; regulation of membrane potential; response to oxidative stress; small GTPase mediated signal transduction; synaptic vesicle; tangential migration from the subventricular zone to the olfactory bulb; trans-Golgi network; tubulin binding IPR020683; IPR011989; IPR016024; IPR011009; IPR001611; IPR025875; IPR003591; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR008271; IPR005225; IPR001806; IPR015943; IPR001680; IPR017986; Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin) LRRK2 PARK8 Homo sapiens (Human) TR42967_c2_g2_i3 Q8SSS9 QKGA_DICDI 8.00E-06 GO:0005524; GO:0005525; GO:0005737; GO:0031158; GO:0008285; GO:0006997; GO:0004674; GO:0007264 ATP binding; GTP binding; cytoplasm; negative regulation of aggregate size involved in sorocarp development; negative regulation of cell proliferation; nucleus organization; protein serine/threonine kinase activity; small GTPase mediated signal transduction IPR011009; IPR001611; IPR013684; IPR027417; IPR000719; IPR017441; IPR020859; IPR001245; Probable serine/threonine-protein kinase qkgA (EC 2.7.11.1) (Quick growth protein qkgA) (Ras of complex proteins and C-terminal of roc 2) qkgA-1 roco2-1 DDB_G0273259; qkgA-2 roco2-2 DDB_G0273635 Dictyostelium discoideum (Slime mold) TR42968_c4_g2_i1 Q55ER0 MANC_DICDI 2.00E-22 GO:0004559; GO:0030246; GO:0005975; GO:0005576; GO:0008270 alpha-mannosidase activity; carbohydrate binding; carbohydrate metabolic process; extracellular region; zinc ion binding IPR011013; IPR011330; IPR013780; IPR027291; IPR015341; IPR000602; Alpha-mannosidase C (EC 3.2.1.24) manC DDB_G0268994 Dictyostelium discoideum (Slime mold) TR42968_c4_g2_i2 Q29451 MA2B1_BOVIN 5.00E-89 GO:0004559; GO:0030246; GO:0005764; GO:0006013; GO:0008270 alpha-mannosidase activity; carbohydrate binding; lysosome; mannose metabolic process; zinc ion binding IPR011013; IPR011330; IPR013780; IPR027291; IPR011682; IPR015341; IPR000602; Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) [Cleaved into: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide] MAN2B1 MANB Bos taurus (Bovine) TR42968_c4_g2_i4 P34098 MANA_DICDI 2.00E-54 GO:0004559; GO:0030246; GO:0005764; GO:0006013; GO:0006517; GO:0030587; GO:0008270 alpha-mannosidase activity; carbohydrate binding; lysosome; mannose metabolic process; protein deglycosylation; sorocarp development; zinc ion binding IPR011013; IPR011330; IPR013780; IPR027291; IPR011682; IPR015341; IPR000602; Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Alpha-mannosidase A) [Cleaved into: Alpha-mannosidase 60 kDa subunit; Alpha-mannosidase 58 kDa subunit] manA DDB_G0292206 Dictyostelium discoideum (Slime mold) TR42968_c4_g4_i2 Q60HE9 MA2B1_MACFA 0 GO:0004559; GO:0030246; GO:0005764; GO:0006013; GO:0008270 alpha-mannosidase activity; carbohydrate binding; lysosome; mannose metabolic process; zinc ion binding IPR011013; IPR011330; IPR013780; IPR027291; IPR011682; IPR015341; IPR000602; Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) MAN2B1 QmoA-10471 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR42968_c4_g4_i5 O09159 MA2B1_MOUSE 0 GO:0004559; GO:0030246; GO:0007611; GO:0005764; GO:0006013; GO:0008270 alpha-mannosidase activity; carbohydrate binding; learning or memory; lysosome; mannose metabolic process; zinc ion binding IPR011013; IPR011330; IPR013780; IPR027291; IPR011682; IPR015341; IPR000602; Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) Man2b1 Laman Man2b Manb Mus musculus (Mouse) TR42968_c4_g4_i6 O09159 MA2B1_MOUSE 7.00E-36 GO:0004559; GO:0030246; GO:0007611; GO:0005764; GO:0006013; GO:0008270 alpha-mannosidase activity; carbohydrate binding; learning or memory; lysosome; mannose metabolic process; zinc ion binding IPR011013; IPR011330; IPR013780; IPR027291; IPR011682; IPR015341; IPR000602; Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) Man2b1 Laman Man2b Manb Mus musculus (Mouse) TR42969_c0_g1_i1 Q9UBX3 DIC_HUMAN 6.00E-91 GO:0015297; GO:0034641; GO:0005310; GO:0006094; GO:0016021; GO:0015140; GO:0005743; GO:0006839; GO:0005634; GO:0015114; GO:0015141; GO:0015116; GO:0008272; GO:0070221; GO:0000098; GO:0015117; GO:0015709 Q99750 "antiporter activity; cellular nitrogen compound metabolic process; dicarboxylic acid transmembrane transporter activity; gluconeogenesis; integral to membrane; malate transmembrane transporter activity; mitochondrial inner membrane; mitochondrial transport; nucleus; phosphate ion transmembrane transporter activity; succinate transmembrane transporter activity; sulfate transmembrane transporter activity; sulfate transport; sulfide oxidation, using sulfide:quinone oxidoreductase; sulfur amino acid catabolic process; thiosulfate transmembrane transporter activity; thiosulfate transport" IPR002030; IPR018108; IPR023395; Mitochondrial dicarboxylate carrier (Solute carrier family 25 member 10) SLC25A10 DIC Homo sapiens (Human) TR42969_c0_g1_i2 Q9CR62 M2OM_MOUSE 2.00E-43 GO:0016021; GO:0005743; GO:0006810 integral to membrane; mitochondrial inner membrane; transport IPR018108; IPR023395; Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute carrier family 25 member 11) Slc25a11 Mus musculus (Mouse) TR42969_c0_g1_i3 Q9GMZ1 UCP1_CANFA 8.00E-27 GO:0016021; GO:0005743; GO:0006839 integral to membrane; mitochondrial inner membrane; mitochondrial transport IPR002030; IPR018108; IPR023395; Mitochondrial brown fat uncoupling protein 1 (UCP 1) (Solute carrier family 25 member 7) (Thermogenin) UCP1 SLC25A7 Canis familiaris (Dog) (Canis lupus familiaris) TR42969_c0_g1_i4 Q58DS3 S2535_BOVIN 1.00E-06 GO:0016021; GO:0005743; GO:0006810 integral to membrane; mitochondrial inner membrane; transport IPR018108; IPR023395; Solute carrier family 25 member 35 SLC25A35 Bos taurus (Bovine) TR42969_c0_g1_i5 Q9UBX3 DIC_HUMAN 2.00E-93 GO:0015297; GO:0034641; GO:0005310; GO:0006094; GO:0016021; GO:0015140; GO:0005743; GO:0006839; GO:0005634; GO:0015114; GO:0015141; GO:0015116; GO:0008272; GO:0070221; GO:0000098; GO:0015117; GO:0015709 Q99750 "antiporter activity; cellular nitrogen compound metabolic process; dicarboxylic acid transmembrane transporter activity; gluconeogenesis; integral to membrane; malate transmembrane transporter activity; mitochondrial inner membrane; mitochondrial transport; nucleus; phosphate ion transmembrane transporter activity; succinate transmembrane transporter activity; sulfate transmembrane transporter activity; sulfate transport; sulfide oxidation, using sulfide:quinone oxidoreductase; sulfur amino acid catabolic process; thiosulfate transmembrane transporter activity; thiosulfate transport" IPR002030; IPR018108; IPR023395; Mitochondrial dicarboxylate carrier (Solute carrier family 25 member 10) SLC25A10 DIC Homo sapiens (Human) TR42970_c1_g2_i1 P51816 AFF2_HUMAN 1.00E-17 GO:0002151; GO:0008380; GO:0007420; GO:0007611; GO:0006397; GO:0016607; GO:0043484 G-quadruplex RNA binding; RNA splicing; brain development; learning or memory; mRNA processing; nuclear speck; regulation of RNA splicing IPR007797; AF4/FMR2 family member 2 (Fragile X E mental retardation syndrome protein) (Fragile X mental retardation 2 protein) (FMR2P) (Protein FMR-2) (Protein Ox19) AFF2 FMR2 OX19 Homo sapiens (Human) TR42971_c2_g2_i2 Q91ZU1 ASB6_MOUSE 3.00E-08 GO:0005737; GO:0035556; GO:0016567 cytoplasm; intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 6 (ASB-6) Asb6 Mus musculus (Mouse) TR42971_c2_g2_i3 Q8Q0U0 Y045_METMA 1.00E-15 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR42971_c2_g2_i4 P53355 DAPK1_HUMAN 8.00E-13 GO:0005524; GO:0015629; GO:0097190; GO:0005516; GO:0004683; GO:0071346; GO:0005737; GO:0007243; GO:0043066; GO:0017148; GO:0043065; GO:0046777; GO:2000310; GO:0010506 Itself; Q14457; Q9Y2M5; Q38SD2; Q5S007; P27361; O75340; P14618; P14618-1 ATP binding; actin cytoskeleton; apoptotic signaling pathway; calmodulin binding; calmodulin-dependent protein kinase activity; cellular response to interferon-gamma; cytoplasm; intracellular protein kinase cascade; negative regulation of apoptotic process; negative regulation of translation; positive regulation of apoptotic process; protein autophosphorylation; regulation of N-methyl-D-aspartate selective glutamate receptor activity; regulation of autophagy IPR002110; IPR020683; IPR011029; IPR000488; IPR011009; IPR020675; IPR027417; IPR000719; IPR017441; IPR002290; IPR008271; Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) DAPK1 DAPK Homo sapiens (Human) TR42971_c2_g3_i1 Q8C6Y6 ASB14_MOUSE 1.00E-06 GO:0035556; GO:0016567 intracellular signal transduction; protein ubiquitination IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 14 Asb14 Mus musculus (Mouse) TR42973_c1_g1_i1 P41216 ACSL1_MOUSE 0 GO:0005524; GO:0033211; GO:0005789; GO:0016021; GO:0008610; GO:0044539; GO:0004467; GO:0005741; GO:0005739; GO:0005778; GO:0005886; GO:0071902; GO:0042493; GO:0007584; GO:0034201; GO:0014070; GO:0006641; GO:0042178 ATP binding; adiponectin-mediated signaling pathway; endoplasmic reticulum membrane; integral to membrane; lipid biosynthetic process; long-chain fatty acid import; long-chain fatty acid-CoA ligase activity; mitochondrial outer membrane; mitochondrion; peroxisomal membrane; plasma membrane; positive regulation of protein serine/threonine kinase activity; response to drug; response to nutrient; response to oleic acid; response to organic cyclic compound; triglyceride metabolic process; xenobiotic catabolic process IPR020845; IPR000873; Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 1) (LACS 1) Acsl1 Acsl2 Facl2 Mus musculus (Mouse) TR42973_c1_g1_i10 O88813 ACSL5_RAT 0 GO:0005524; GO:0032869; GO:0005789; GO:0015908; GO:0016021; GO:0004467; GO:0005741; GO:0005739; GO:0008654; GO:0032000; GO:0010747; GO:0010867; GO:0070723; GO:0009749; GO:0007584; GO:0009744 ATP binding; cellular response to insulin stimulus; endoplasmic reticulum membrane; fatty acid transport; integral to membrane; long-chain fatty acid-CoA ligase activity; mitochondrial outer membrane; mitochondrion; phospholipid biosynthetic process; positive regulation of fatty acid beta-oxidation; positive regulation of plasma membrane long-chain fatty acid transport; positive regulation of triglyceride biosynthetic process; response to cholesterol; response to glucose stimulus; response to nutrient; response to sucrose stimulus IPR020845; IPR000873; Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5) Acsl5 Acs5 Facl5 Rattus norvegicus (Rat) TR42973_c1_g1_i2 Q00594 ALKK_PSEOL 8.00E-07 GO:0005524; GO:0005737; GO:0006631; GO:0016874; GO:0046872 ATP binding; cytoplasm; fatty acid metabolic process; ligase activity; metal ion binding IPR025110; IPR020845; IPR000873; Lipid metabolism; fatty acid metabolism. Medium-chain-fatty-acid--CoA ligase (EC 6.2.1.-) (Medium-chain acyl-CoA synthetase) alkK Pseudomonas oleovorans TR42973_c1_g1_i6 Q9JID6 ACSL1_CAVPO 0 GO:0005524; GO:0005789; GO:0001676; GO:0004467; GO:0005741; GO:0005778 ATP binding; endoplasmic reticulum membrane; long-chain fatty acid metabolic process; long-chain fatty acid-CoA ligase activity; mitochondrial outer membrane; peroxisomal membrane IPR020845; IPR000873; Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Palmitoyl-CoA ligase) ACSL1 FACL1 LACS1 Cavia porcellus (Guinea pig) TR42973_c1_g1_i7 Q7TYX8 FAC15_MYCBO 1.00E-50 GO:0005524; GO:0006633; GO:0001676; GO:0004467 ATP binding; fatty acid biosynthetic process; long-chain fatty acid metabolic process; long-chain fatty acid-CoA ligase activity IPR020845; IPR000873; Lipid metabolism; fatty acid biosynthesis. Long-chain-fatty-acid--CoA ligase FadD15 (FACL) (EC 6.2.1.3) (Acyl-CoA synthetase) fadD15 Mb2210 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) TR42973_c1_g1_i8 Q9JID6 ACSL1_CAVPO 0 GO:0005524; GO:0005789; GO:0001676; GO:0004467; GO:0005741; GO:0005778 ATP binding; endoplasmic reticulum membrane; long-chain fatty acid metabolic process; long-chain fatty acid-CoA ligase activity; mitochondrial outer membrane; peroxisomal membrane IPR020845; IPR000873; Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Palmitoyl-CoA ligase) ACSL1 FACL1 LACS1 Cavia porcellus (Guinea pig) TR42973_c1_g1_i9 Q9UKU0 ACSL6_HUMAN 0 GO:0005524; GO:0032869; GO:0005789; GO:0015908; GO:0016021; GO:0004467; GO:0035338; GO:0016020; GO:0005741; GO:0007405; GO:0048666; GO:0005634; GO:0005778; GO:0008654; GO:0005886; GO:0010976; GO:0010747; GO:0010867; GO:0042803; GO:0009629; GO:0001666; GO:0007584; GO:0048545; GO:0019432 ATP binding; cellular response to insulin stimulus; endoplasmic reticulum membrane; fatty acid transport; integral to membrane; long-chain fatty acid-CoA ligase activity; long-chain fatty-acyl-CoA biosynthetic process; membrane; mitochondrial outer membrane; neuroblast proliferation; neuron development; nucleus; peroxisomal membrane; phospholipid biosynthetic process; plasma membrane; positive regulation of neuron projection development; positive regulation of plasma membrane long-chain fatty acid transport; positive regulation of triglyceride biosynthetic process; protein homodimerization activity; response to gravity; response to hypoxia; response to nutrient; response to steroid hormone stimulus; triglyceride biosynthetic process IPR020845; IPR000873; Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 6) (LACS 6) ACSL6 ACS2 FACL6 KIAA0837 LACS5 Homo sapiens (Human) TR42976_c0_g1_i1 Q9D0U6 MAF1_MOUSE 4.00E-79 GO:0001030; GO:0001031; GO:0001032; GO:0030424; GO:0005829; GO:0030425; GO:0060077; GO:0016480; GO:0005634; GO:0005886; GO:0006351 "RNA polymerase III type 1 promoter DNA binding; RNA polymerase III type 2 promoter DNA binding; RNA polymerase III type 3 promoter DNA binding; axon; cytosol; dendrite; inhibitory synapse; negative regulation of transcription from RNA polymerase III promoter; nucleus; plasma membrane; transcription, DNA-dependent" IPR015257; Repressor of RNA polymerase III transcription MAF1 homolog Maf1 Mus musculus (Mouse) TR42976_c0_g1_i4 Q9D0U6 MAF1_MOUSE 5.00E-82 GO:0001030; GO:0001031; GO:0001032; GO:0030424; GO:0005829; GO:0030425; GO:0060077; GO:0016480; GO:0005634; GO:0005886; GO:0006351 "RNA polymerase III type 1 promoter DNA binding; RNA polymerase III type 2 promoter DNA binding; RNA polymerase III type 3 promoter DNA binding; axon; cytosol; dendrite; inhibitory synapse; negative regulation of transcription from RNA polymerase III promoter; nucleus; plasma membrane; transcription, DNA-dependent" IPR015257; Repressor of RNA polymerase III transcription MAF1 homolog Maf1 Mus musculus (Mouse) TR42977_c0_g1_i1 Q5VYK3 ECM29_HUMAN 0 GO:0030134; GO:0030433; GO:0005813; GO:0005769; GO:0030139; GO:0005783; GO:0005793; GO:0005771; GO:0005634; GO:0000502 ER to Golgi transport vesicle; ER-associated protein catabolic process; centrosome; early endosome; endocytic vesicle; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; multivesicular body; nucleus; proteasome complex IPR011989; IPR016024; IPR026827; IPR026826; IPR024372; Proteasome-associated protein ECM29 homolog (Ecm29) ECM29 KIAA0368 Homo sapiens (Human) TR42978_c3_g2_i1 P08548 LIN1_NYCCO 9.00E-43 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR42978_c4_g2_i6 Q9H606 CY017_HUMAN 2.00E-08 IPR013544; Putative uncharacterized protein CYorf17 CYorf17 Homo sapiens (Human) TR42981_c1_g1_i1 Q6PGP7 TTC37_HUMAN 0 GO:0055087; GO:0005634; GO:0035327 Q8N7H5 Ski complex; nucleus; transcriptionally active chromatin IPR006597; IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 37 (TPR repeat protein 37) (SKI3 homolog) (Ski3) (Tricho-hepatic-enteric syndrome protein) (Thespin) TTC37 KIAA0372 Homo sapiens (Human) TR42981_c1_g1_i2 Q6DFB8 TTC37_XENLA 0 GO:0055087; GO:0005634; GO:0035327 Ski complex; nucleus; transcriptionally active chromatin IPR013026; IPR011990; IPR001440; IPR013105; IPR019734; Tetratricopeptide repeat protein 37 (TPR repeat protein 37) (Thespin homolog) ttc37 Xenopus laevis (African clawed frog) TR42981_c1_g1_i4 Q6PGP7 TTC37_HUMAN 2.00E-22 GO:0055087; GO:0005634; GO:0035327 Q8N7H5 Ski complex; nucleus; transcriptionally active chromatin IPR006597; IPR013026; IPR011990; IPR001440; IPR019734; Tetratricopeptide repeat protein 37 (TPR repeat protein 37) (SKI3 homolog) (Ski3) (Tricho-hepatic-enteric syndrome protein) (Thespin) TTC37 KIAA0372 Homo sapiens (Human) TR42982_c1_g1_i1 Q0CT27 CCR4_ASPTN 5.00E-13 GO:0003723; GO:0005737; GO:0046872; GO:0090305; GO:0005634; GO:0004535; GO:0006355; GO:0006351 "RNA binding; cytoplasm; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleus; poly(A)-specific ribonuclease activity; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR005135; IPR001611; IPR025875; IPR003591; Glucose-repressible alcohol dehydrogenase transcriptional effector (EC 3.1.13.4) (Carbon catabolite repressor protein 4) (Cytoplasmic deadenylase) ccr4 ATEG_03157 Aspergillus terreus (strain NIH 2624 / FGSC A1156) TR42982_c1_g2_i1 B4JTV9 SUR8_DROGR 0 GO:0046579; GO:0000164 positive regulation of Ras protein signal transduction; protein phosphatase type 1 complex IPR001611; IPR025875; IPR003591; IPR027036; Leucine-rich repeat protein soc-2 homolog (Protein Sur-8 homolog) (Protein soc-2 homolog) Sur-8 GH17496 Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) TR42983_c3_g1_i1 P32255 TBA_DICDI 0 GO:0005525; GO:0003924; GO:0005813; GO:0007059; GO:0005874; GO:0007017; GO:0045335; GO:0051258; GO:0005200 GTP binding; GTPase activity; centrosome; chromosome segregation; microtubule; microtubule-based process; phagocytic vesicle; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha chain (Alpha-tubulin) tubA DDB_G0287689 Dictyostelium discoideum (Slime mold) TR42983_c3_g1_i2 Q9D6T1 TBE_MOUSE 4.00E-59 GO:0005525; GO:0003924; GO:0051297; GO:0005874; GO:0000242; GO:0051258 GTP binding; GTPase activity; centrosome organization; microtubule; pericentriolar material; protein polymerization IPR004057; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin epsilon chain (Epsilon-tubulin) Tube1 Mus musculus (Mouse) TR42983_c3_g1_i4 Q68FR8 TBA3_RAT 0 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-3 chain (Alpha-tubulin 3) Tuba3a Tuba3; Tuba3b Tuba3 Rattus norvegicus (Rat) TR42984_c1_g3_i1 Q0V8M0 KRI1_BOVIN 1.00E-89 IPR024626; IPR018034; Protein KRI1 homolog KRI1 Bos taurus (Bovine) TR42984_c1_g3_i3 Q09799 KRI1_SCHPO 3.00E-18 GO:0044732; GO:0005730; GO:0005634; GO:0006364 mitotic spindle pole body; nucleolus; nucleus; rRNA processing IPR024626; IPR018034; Protein kri1 kri1 SPAC22G7.05 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42987_c1_g3_i1 Q8TGK8 YP160_YEAST 1.00E-16 Uncharacterized protein YPR160C-A YPR160C-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42987_c1_g3_i4 Q9XTL9 PYG_DROME 0 GO:0050829; GO:0060361; GO:0005980; GO:0008184; GO:0045824; GO:0030170 defense response to Gram-negative bacterium; flight; glycogen catabolic process; glycogen phosphorylase activity; negative regulation of innate immune response; pyridoxal phosphate binding IPR011833; IPR000811; Glycogen phosphorylase (EC 2.4.1.1) GlyP Glp1 CG7254 Drosophila melanogaster (Fruit fly) TR42988_c1_g1_i3 Q24331 TID_DROVI 2.00E-136 GO:0005524; GO:0046872; GO:0005741; GO:0007275; GO:0006457; GO:0009408 ATP binding; metal ion binding; mitochondrial outer membrane; multicellular organismal development; protein folding; response to heat IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; "Protein tumorous imaginal discs, mitochondrial (Protein lethal(2)tumorous imaginal discs) (TID58)" l(2)tid tid Drosophila virilis (Fruit fly) TR42988_c1_g1_i4 Q27237 TID_DROME 2.00E-131 GO:0005524; GO:0005829; GO:0046872; GO:0005741; GO:0005739; GO:0007275; GO:0006457; GO:0009408; GO:0007224 ATP binding; cytosol; metal ion binding; mitochondrial outer membrane; mitochondrion; multicellular organismal development; protein folding; response to heat; smoothened signaling pathway IPR012724; IPR002939; IPR001623; IPR018253; IPR008971; IPR001305; "Protein tumorous imaginal discs, mitochondrial (Protein lethal(2)tumorous imaginal discs) (TID50) (TID56)" l(2)tid CG5504 Drosophila melanogaster (Fruit fly) TR42989_c0_g2_i1 Q8CFA2 GCST_MOUSE 4.00E-99 GO:0004047; GO:0006546; GO:0005739; GO:0008483 aminomethyltransferase activity; glycine catabolic process; mitochondrion; transaminase activity IPR013977; IPR006222; IPR006223; IPR027266; "Aminomethyltransferase, mitochondrial (EC 2.1.2.10) (Glycine cleavage system T protein) (GCVT)" Amt Mus musculus (Mouse) TR42990_c1_g2_i2 Q38931 FKB62_ARATH 5.00E-29 GO:0070370; GO:0005737; GO:0005634; GO:0003755; GO:0006457; GO:0000413 D6RUV9; Q9FJL3; P27323 cellular heat acclimation; cytoplasm; nucleus; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR023566; IPR001179; IPR013026; IPR011990; IPR001440; IPR019734; Peptidyl-prolyl cis-trans isomerase FKBP62 (PPIase FKBP62) (EC 5.2.1.8) (70 kDa peptidyl-prolyl isomerase) (FK506-binding protein 62) (AtFKBP62) (Immunophilin FKBP62) (Peptidylprolyl isomerase ROF1) (Protein ROTAMASE FKBP 1) (Rotamase) FKBP62 ROF1 At3g25230 MJL12.19 Arabidopsis thaliana (Mouse-ear cress) TR42990_c1_g2_i3 P48375 FKB12_DROME 9.00E-46 GO:0005528; GO:0005737; GO:0016020; GO:0003755; GO:0006457; GO:0006974 FK506 binding; cytoplasm; membrane; peptidyl-prolyl cis-trans isomerase activity; protein folding; response to DNA damage stimulus IPR023566; IPR001179; 12 kDa FK506-binding protein (FKBP) (EC 5.2.1.8) (Macrolide-binding protein) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) FK506-bp2 FKBP12 CG11001 Drosophila melanogaster (Fruit fly) TR42991_c4_g1_i1 Q7Z0T3 TEMPT_APLCA 2.00E-34 GO:0005576 extracellular region Temptin Aplysia californica (California sea hare) TR42991_c5_g1_i1 Q9XTQ6 TBH1_CAEEL 2.00E-36 GO:0006584; GO:0030054; GO:0005507; GO:0004500; GO:0042136; GO:0045202; GO:0008021 catecholamine metabolic process; cell junction; copper ion binding; dopamine beta-monooxygenase activity; neurotransmitter biosynthetic process; synapse; synaptic vesicle IPR014784; IPR020611; IPR000323; IPR000945; IPR005018; IPR008977; Tyramine beta-hydroxylase (EC 1.14.17.-) tbh-1 H13N06.6 Caenorhabditis elegans TR42992_c1_g1_i1 P60924 DELE_RAT 2.00E-28 GO:0008625; GO:0005739; GO:0043281 extrinsic apoptotic signaling pathway via death domain receptors; mitochondrion; regulation of cysteine-type endopeptidase activity involved in apoptotic process IPR006597; IPR011990; Death ligand signal enhancer Dele Rattus norvegicus (Rat) TR42994_c5_g2_i1 P62309 RUXG_MOUSE 5.00E-34 GO:0003723; GO:0008380; GO:0005689; GO:0005683; GO:0071013; GO:0006397 RNA binding; RNA splicing; U12-type spliceosomal complex; U7 snRNP; catalytic step 2 spliceosome; mRNA processing IPR010920; IPR001163; IPR006649; Small nuclear ribonucleoprotein G (snRNP-G) (Sm protein G) (Sm-G) (SmG) Snrpg Mus musculus (Mouse) TR42995_c1_g1_i1 P20147 HSP90_PLAFP 2.00E-35 GO:0005524; GO:0005737; GO:0006457; GO:0006950 ATP binding; cytoplasm; protein folding; response to stress IPR001404; Heat shock 90 kDa protein homolog (Fragment) Plasmodium falciparum (isolate Palo Alto / Uganda) TR42995_c1_g3_i1 Q66HD0 ENPL_RAT 0 GO:0005524; GO:0030433; GO:0003723; GO:0031247; GO:0071318; GO:0005829; GO:0005788; GO:0005789; GO:0042470; GO:0030496; GO:0043066; GO:0048471; GO:0005886; GO:0006457; GO:0043666; GO:0001666; GO:0005790; GO:0046790 ATP binding; ER-associated protein catabolic process; RNA binding; actin rod assembly; cellular response to ATP; cytosol; endoplasmic reticulum lumen; endoplasmic reticulum membrane; melanosome; midbody; negative regulation of apoptotic process; perinuclear region of cytoplasm; plasma membrane; protein folding; regulation of phosphoprotein phosphatase activity; response to hypoxia; smooth endoplasmic reticulum; virion binding IPR015566; IPR003594; IPR019805; IPR001404; IPR020575; IPR020568; Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) Hsp90b1 Grp94 Tra1 Rattus norvegicus (Rat) TR42995_c1_g3_i2 Q58FF8 H90B2_HUMAN 6.00E-31 GO:0005524; GO:0005737; GO:0006457; GO:0006950 ATP binding; cytoplasm; protein folding; response to stress IPR003594; IPR001404; IPR020575; IPR020568; Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) HSP90AB2P HSP90BB Homo sapiens (Human) TR42995_c1_g3_i3 Q95M18 ENPL_BOVIN 1.00E-08 GO:0005524; GO:0030433; GO:0003723; GO:0031247; GO:0071318; GO:0005829; GO:0005783; GO:0005788; GO:0005789; GO:0050750; GO:0042470; GO:0030496; GO:0043066; GO:0048471; GO:0005886; GO:0006457; GO:0043666; GO:0001666; GO:0046790 ATP binding; ER-associated protein catabolic process; RNA binding; actin rod assembly; cellular response to ATP; cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; low-density lipoprotein particle receptor binding; melanosome; midbody; negative regulation of apoptotic process; perinuclear region of cytoplasm; plasma membrane; protein folding; regulation of phosphoprotein phosphatase activity; response to hypoxia; virion binding IPR015566; IPR003594; IPR019805; IPR001404; IPR020575; IPR020568; Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) HSP90B1 GRP94 TRA1 Bos taurus (Bovine) TR42996_c1_g1_i1 P31007 DLG1_DROME 1.00E-15 GO:0030714; GO:0045179; GO:0016327; GO:0045167; GO:0045175; GO:0016323; GO:0007155; GO:0060581; GO:0001708; GO:0005856; GO:0007391; GO:0005154; GO:0051294; GO:0045197; GO:0045196; GO:0016332; GO:0016336; GO:0042332; GO:0004385; GO:0016328; GO:0045475; GO:0008049; GO:0001738; GO:0008285; GO:0000122; GO:0031594; GO:0048471; GO:0007318; GO:0046956; GO:0045887; GO:0045211; GO:0046425; GO:0008593; GO:0030710; GO:0051726; GO:0042058; GO:0019991; GO:0004871; GO:0005920; GO:0005198; GO:0051124; GO:0061176 Q4AB30; Q9VE13 "anterior/posterior axis specification, follicular epithelium; apical cortex; apicolateral plasma membrane; asymmetric protein localization involved in cell fate determination; basal protein localization; basolateral plasma membrane; cell adhesion; cell fate commitment involved in pattern specification; cell fate specification; cytoskeleton; dorsal closure; epidermal growth factor receptor binding; establishment of spindle orientation; establishment or maintenance of epithelial cell apical/basal polarity; establishment or maintenance of neuroblast polarity; establishment or maintenance of polarity of embryonic epithelium; establishment or maintenance of polarity of larval imaginal disc epithelium; gravitaxis; guanylate kinase activity; lateral plasma membrane; locomotor rhythm; male courtship behavior; morphogenesis of a polarized epithelium; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; neuromuscular junction; perinuclear region of cytoplasm; pole plasm protein localization; positive phototaxis; positive regulation of synaptic growth at neuromuscular junction; postsynaptic membrane; regulation of JAK-STAT cascade; regulation of Notch signaling pathway; regulation of border follicle cell delamination; regulation of cell cycle; regulation of epidermal growth factor receptor signaling pathway; septate junction assembly; signal transducer activity; smooth septate junction; structural molecule activity; synaptic growth at neuromuscular junction; type Ib terminal bouton" IPR008145; IPR008144; IPR020590; IPR004172; IPR015143; IPR027417; IPR001478; IPR001452; Disks large 1 tumor suppressor protein dlg1 l(1)dlg1 CG1725 Drosophila melanogaster (Fruit fly) TR42996_c1_g2_i1 Q8TDM6 DLG5_HUMAN 2.00E-75 GO:0008013; GO:0005913; GO:0016337; GO:0005737; GO:0008092; GO:0035556; GO:0008285; GO:0005886; GO:0030159; GO:0042981 Q64729; Q62312 beta-catenin binding; cell-cell adherens junction; cell-cell adhesion; cytoplasm; cytoskeletal protein binding; intracellular signal transduction; negative regulation of cell proliferation; plasma membrane; receptor signaling complex scaffold activity; regulation of apoptotic process IPR001315; IPR011029; IPR006907; IPR008145; IPR008144; IPR027417; IPR001478; IPR001452; Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) DLG5 KIAA0583 PDLG Homo sapiens (Human) TR42997_c0_g1_i1 P49841 GSK3B_HUMAN 0 GO:0005524; GO:0006983; GO:0038095; GO:0007411; GO:0030877; GO:0060070; GO:0044337; GO:0016477; GO:0036016; GO:0005813; GO:0007623; GO:0005829; GO:0043198; GO:0043197; GO:0007173; GO:0001837; GO:0030010; GO:0097192; GO:0045444; GO:0008543; GO:0005977; GO:0030426; GO:0021766; GO:0044027; GO:0045087; GO:0045121; GO:0007520; GO:0043407; GO:0051534; GO:0043066; GO:0090090; GO:0050774; GO:2000466; GO:0045719; GO:0032091; GO:0031333; GO:0045892; GO:2000077; GO:0043025; GO:0048011; GO:0005634; GO:0009887; GO:0002039; GO:0018105; GO:0048471; GO:0048015; GO:0005886; GO:0032855; GO:0001954; GO:1901030; GO:0033138; GO:0010800; GO:0032092; GO:0045732; GO:0031334; GO:0046827; GO:2000738; GO:0045944; GO:0006611; GO:0035372; GO:0004674; GO:0000320; GO:0006349; GO:0032886; GO:0048168; GO:0042493; GO:0010226; GO:0030529; GO:0071109; GO:0050321 P31749; P31751; O15169; O35625; Q14DJ8; Q96G01; P35222; Q9NYF0; O75398; Q811T9; O75581; P63085; P10636; P10636-8; Q8N4C6; P17612; Q01201; O95863; P37840; Q6J9G0; P04637; Q14134; P63104; Q8IX07 "ATP binding; ER overload response; Fc-epsilon receptor signaling pathway; axon guidance; beta-catenin destruction complex; canonical Wnt receptor signaling pathway; canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process; cell migration; cellular response to interleukin-3; centrosome; circadian rhythm; cytosol; dendritic shaft; dendritic spine; epidermal growth factor receptor signaling pathway; epithelial to mesenchymal transition; establishment of cell polarity; extrinsic apoptotic signaling pathway in absence of ligand; fat cell differentiation; fibroblast growth factor receptor signaling pathway; glycogen metabolic process; growth cone; hippocampus development; hypermethylation of CpG island; innate immune response; membrane raft; myoblast fusion; negative regulation of MAP kinase activity; negative regulation of NFAT protein import into nucleus; negative regulation of apoptotic process; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of dendrite morphogenesis; negative regulation of glycogen (starch) synthase activity; negative regulation of glycogen biosynthetic process; negative regulation of protein binding; negative regulation of protein complex assembly; negative regulation of transcription, DNA-dependent; negative regulation of type B pancreatic cell development; neuronal cell body; neurotrophin TRK receptor signaling pathway; nucleus; organ morphogenesis; p53 binding; peptidyl-serine phosphorylation; perinuclear region of cytoplasm; phosphatidylinositol-mediated signaling; plasma membrane; positive regulation of Rac GTPase activity; positive regulation of cell-matrix adhesion; positive regulation of mitochondrial outer membrane permeabilization; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of protein binding; positive regulation of protein catabolic process; positive regulation of protein complex assembly; positive regulation of protein export from nucleus; positive regulation of stem cell differentiation; positive regulation of transcription from RNA polymerase II promoter; protein export from nucleus; protein localization to microtubule; protein serine/threonine kinase activity; re-entry into mitotic cell cycle; regulation of gene expression by genetic imprinting; regulation of microtubule-based process; regulation of neuronal synaptic plasticity; response to drug; response to lithium ion; ribonucleoprotein complex; superior temporal gyrus development; tau-protein kinase activity" IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) GSK3B Homo sapiens (Human) TR42998_c1_g1_i5 P53490 ARP3_ACACA 0 GO:0005524; GO:0034314; GO:0005885; GO:0042995; GO:0005737 ATP binding; Arp2/3 complex-mediated actin nucleation; Arp2/3 protein complex; cell projection; cytoplasm IPR004000; IPR020902; IPR015623; Actin-related protein 3 (Actin-like protein 3) ARP3 Acanthamoeba castellanii (Amoeba) TR42998_c1_g1_i6 Q5R8R1 ARP3_PONAB 0 GO:0005524; GO:0008356; GO:0060271; GO:0005737; GO:0005856; GO:0007163; GO:0030027; GO:0033206; GO:0051653 ATP binding; asymmetric cell division; cilium morphogenesis; cytoplasm; cytoskeleton; establishment or maintenance of cell polarity; lamellipodium; meiotic cytokinesis; spindle localization IPR004000; IPR020902; Actin-related protein 3 (Actin-like protein 3) ACTR3 ARP3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42998_c1_g2_i3 Q9P1U1 ARP3B_HUMAN 3.00E-20 GO:0005524; GO:0042995; GO:0005737; GO:0005856 ATP binding; cell projection; cytoplasm; cytoskeleton IPR004000; IPR020902; Actin-related protein 3B (ARP3-beta) (Actin-like protein 3B) (Actin-related protein ARP4) ACTR3B ARP11 ARP4 Homo sapiens (Human) TR43001_c1_g1_i10 Q86YP4 P66A_HUMAN 2.00E-40 GO:0006306; GO:0016581; GO:0021506; GO:0001568; GO:0010172; GO:0001701; GO:0045892; GO:0001842; GO:0016607; GO:0005634; GO:0012501; GO:0030674; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "DNA methylation; NuRD complex; anterior neuropore closure; blood vessel development; embryonic body morphogenesis; in utero embryonic development; negative regulation of transcription, DNA-dependent; neural fold formation; nuclear speck; nucleus; programmed cell death; protein binding, bridging; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR000679; IPR013088; Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) GATAD2A Homo sapiens (Human) TR43001_c1_g1_i14 Q8CHY6 P66A_MOUSE 2.00E-18 GO:0016581; GO:0021506; GO:0001568; GO:0010172; GO:0001701; GO:0046872; GO:0045892; GO:0001842; GO:0016607; GO:0012501; GO:0030674; GO:0006351 "NuRD complex; anterior neuropore closure; blood vessel development; embryonic body morphogenesis; in utero embryonic development; metal ion binding; negative regulation of transcription, DNA-dependent; neural fold formation; nuclear speck; programmed cell death; protein binding, bridging; transcription, DNA-dependent" Transcriptional repressor p66 alpha (GATA zinc finger domain-containing protein 2A) Gatad2a Mus musculus (Mouse) TR43001_c1_g1_i2 Q8VHR5 P66B_MOUSE 2.00E-40 GO:0016607; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "nuclear speck; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR000679; IPR013088; Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) Gatad2b Mus musculus (Mouse) TR43001_c1_g1_i4 Q8CHY6 P66A_MOUSE 8.00E-39 GO:0016581; GO:0021506; GO:0001568; GO:0010172; GO:0001701; GO:0046872; GO:0045892; GO:0001842; GO:0016607; GO:0012501; GO:0030674; GO:0006351 "NuRD complex; anterior neuropore closure; blood vessel development; embryonic body morphogenesis; in utero embryonic development; metal ion binding; negative regulation of transcription, DNA-dependent; neural fold formation; nuclear speck; programmed cell death; protein binding, bridging; transcription, DNA-dependent" Transcriptional repressor p66 alpha (GATA zinc finger domain-containing protein 2A) Gatad2a Mus musculus (Mouse) TR43001_c1_g1_i5 Q8VHR5 P66B_MOUSE 4.00E-42 GO:0016607; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "nuclear speck; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR000679; IPR013088; Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) Gatad2b Mus musculus (Mouse) TR43001_c1_g1_i7 Q8VHR5 P66B_MOUSE 3.00E-40 GO:0016607; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "nuclear speck; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR000679; IPR013088; Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) Gatad2b Mus musculus (Mouse) TR43001_c1_g1_i9 Q8VHR5 P66B_MOUSE 1.00E-40 GO:0016607; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "nuclear speck; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR000679; IPR013088; Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) Gatad2b Mus musculus (Mouse) TR43002_c3_g4_i1 Q2TFN9 HSP74_CANFA 0 GO:0005524; GO:0005737; GO:0006950 O97758 ATP binding; cytoplasm; response to stress IPR018181; IPR013126; Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2) HSPA4 APG2 Canis familiaris (Dog) (Canis lupus familiaris) TR43002_c3_g4_i4 P12077 HSP74_LEIMA 7.00E-18 GO:0005524; GO:0006950 ATP binding; response to stress IPR018181; IPR013126; Heat shock 70-related protein 4 (Fragment) HSP70.4 Leishmania major TR43002_c3_g4_i5 P48722 HS74L_MOUSE 0 GO:0005524; GO:0005737; GO:0005634; GO:0006457; GO:0006986 ATP binding; cytoplasm; nucleus; protein folding; response to unfolded protein IPR018181; IPR013126; Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Osmotic stress protein 94) Hspa4l Apg1 Hsp4l Osp94 Mus musculus (Mouse) TR43004_c0_g2_i3 Q8R1X6 SPG20_MOUSE 2.00E-68 GO:0009838; GO:0060612; GO:0051301; GO:0005811; GO:0034389; GO:0030496; GO:0005741; GO:0030514; GO:0048698; GO:0050905; GO:0051881; GO:0045202 abscission; adipose tissue development; cell division; lipid particle; lipid particle organization; midbody; mitochondrial outer membrane; negative regulation of BMP signaling pathway; negative regulation of collateral sprouting in absence of injury; neuromuscular process; regulation of mitochondrial membrane potential; synapse IPR007330; IPR009686; Spartin Spg20 Kiaa0610 Mus musculus (Mouse) TR43004_c0_g2_i4 Q8R1X6 SPG20_MOUSE 7.00E-68 GO:0009838; GO:0060612; GO:0051301; GO:0005811; GO:0034389; GO:0030496; GO:0005741; GO:0030514; GO:0048698; GO:0050905; GO:0051881; GO:0045202 abscission; adipose tissue development; cell division; lipid particle; lipid particle organization; midbody; mitochondrial outer membrane; negative regulation of BMP signaling pathway; negative regulation of collateral sprouting in absence of injury; neuromuscular process; regulation of mitochondrial membrane potential; synapse IPR007330; IPR009686; Spartin Spg20 Kiaa0610 Mus musculus (Mouse) TR43004_c0_g2_i5 A0JNJ3 SPG20_BOVIN 9.00E-35 GO:0009838; GO:0051301; GO:0030496; GO:0005741; GO:0051881 abscission; cell division; midbody; mitochondrial outer membrane; regulation of mitochondrial membrane potential IPR007330; IPR009686; Spartin SPG20 Bos taurus (Bovine) TR43005_c1_g1_i1 O54924 EXOC8_RAT 2.00E-169 GO:0034613; GO:0000145; GO:0006887; GO:0030426; GO:0005634; GO:0048471; GO:0005543; GO:0015031 cellular protein localization; exocyst; exocytosis; growth cone; nucleus; perinuclear region of cytoplasm; phospholipid binding; protein transport IPR016159; IPR011993; IPR001849; Exocyst complex component 8 (Exocyst complex 84 kDa subunit) Exoc8 Exo84 Rattus norvegicus (Rat) TR43005_c1_g1_i3 Q5U247 EXOC8_XENLA 6.00E-175 GO:0005737; GO:0006887; GO:0005543; GO:0015031 cytoplasm; exocytosis; phospholipid binding; protein transport IPR016159; IPR011993; IPR001849; Exocyst complex component 8 exoc8 Xenopus laevis (African clawed frog) TR43005_c1_g1_i5 Q5U247 EXOC8_XENLA 3.00E-98 GO:0005737; GO:0006887; GO:0005543; GO:0015031 cytoplasm; exocytosis; phospholipid binding; protein transport IPR016159; IPR011993; IPR001849; Exocyst complex component 8 exoc8 Xenopus laevis (African clawed frog) TR43006_c1_g1_i1 B3DLH6 MYOF_XENTR 1.00E-103 GO:0005901; GO:0030659; GO:0016021; GO:0031965; GO:0005543; GO:0001778 caveola; cytoplasmic vesicle membrane; integral to membrane; nuclear membrane; phospholipid binding; plasma membrane repair IPR000008; IPR012968; IPR012560; IPR012561; IPR006614; Myoferlin (Fer-1-like protein 3) myof fer1l3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR43006_c1_g1_i3 O95294 RASL1_HUMAN 4.00E-12 GO:0005099; GO:0005737; GO:0035556; GO:0031235; GO:0046872; GO:0046580; GO:0005543; GO:0007165 Ras GTPase activator activity; cytoplasm; intracellular signal transduction; intrinsic to internal side of plasma membrane; metal ion binding; negative regulation of Ras protein signal transduction; phospholipid binding; signal transduction IPR000008; IPR011993; IPR001849; IPR001936; IPR023152; IPR008936; IPR001562; RasGAP-activating-like protein 1 RASAL1 RASAL Homo sapiens (Human) TR43006_c1_g1_i4 Q86KB1 ADCB_DICDI 4.00E-09 GO:0007165 signal transduction IPR011021; IPR014752; IPR011022; IPR000008; IPR014756; Arrestin domain-containing protein B adcB DDB_G0274395 Dictyostelium discoideum (Slime mold) TR43006_c1_g1_i5 Q9Y2J0 RP3A_HUMAN 3.00E-08 GO:0005509; GO:0005544; GO:0030054; GO:0006886; GO:0016020; GO:0008021; GO:0005215 O14936 calcium ion binding; calcium-dependent phospholipid binding; cell junction; intracellular protein transport; membrane; synaptic vesicle; transporter activity IPR000008; IPR001565; IPR017455; IPR010911; IPR011011; IPR013083; Rabphilin-3A (Exophilin-1) RPH3A KIAA0985 Homo sapiens (Human) TR43006_c1_g5_i1 O75923 DYSF_HUMAN 0 GO:0030315; GO:0005544; GO:0030659; GO:0016021; GO:0030027; GO:0005886; GO:0001778; GO:0006906 P35609; Q8TCU4; Q9UKG1; Q8N3K9; P17661; Q16760; O75190; Q14315; Q00872; P52179; P54296; P20929; Q96CV9; Q9Y3Z3; Q13326; O95295; Q8WZ42 T-tubule; calcium-dependent phospholipid binding; cytoplasmic vesicle membrane; integral to membrane; lamellipodium; plasma membrane; plasma membrane repair; vesicle fusion IPR000008; IPR012968; IPR012560; IPR012561; IPR010482; IPR006614; Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1) DYSF FER1L1 Homo sapiens (Human) TR43007_c2_g1_i1 P18173 DHGL_DROME 2.00E-20 GO:0006066; GO:0008812; GO:0005576; GO:0050660; GO:0004344; GO:0006006; GO:0008364; GO:0046693 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding; glucose dehydrogenase activity; glucose metabolic process; pupal chitin-based cuticle development; sperm storage IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld CG1152 Drosophila melanogaster (Fruit fly) TR43007_c2_g1_i2 P81156 GOX_PENAG 4.00E-07 GO:0006066; GO:0008812; GO:0005576; GO:0050660; GO:0046562 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding; glucose oxidase activity IPR027424; IPR012132; IPR000172; IPR007867; Glucose oxidase (EC 1.1.3.4) (Beta-D-glucose:oxygen 1-oxido-reductase) (Glucose oxyhydrase) (GOD) Penicillium amagasakiense TR43007_c2_g1_i3 P21286 Y033_NPVAC 4.00E-24 IPR023214; IPR006549; IPR013954; IPR006551; Uncharacterized 20.8 kDa protein in FGF-VUBI intergenic region (ORF 1) Autographa californica nuclear polyhedrosis virus (AcMNPV) TR43007_c2_g1_i4 Q96T60 PNKP_HUMAN 2.00E-35 GO:0005524; GO:0046404; GO:0042769; GO:0006261; GO:0003684; GO:0003690; GO:0004519; GO:0005730; GO:0019201; GO:0000718; GO:0046403; GO:0006979; GO:0009314 P18887; Q13426 "ATP binding; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; DNA damage response, detection of DNA damage; DNA-dependent DNA replication; damaged DNA binding; double-stranded DNA binding; endonuclease activity; nucleolus; nucleotide kinase activity; nucleotide-excision repair, DNA damage removal; polynucleotide 3'-phosphatase activity; response to oxidative stress; response to radiation" IPR000253; IPR023214; IPR006549; IPR027417; IPR013954; IPR006550; IPR006551; IPR008984; Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] PNKP Homo sapiens (Human) TR43007_c2_g2_i1 Q96T60 PNKP_HUMAN 8.00E-36 GO:0005524; GO:0046404; GO:0042769; GO:0006261; GO:0003684; GO:0003690; GO:0004519; GO:0005730; GO:0019201; GO:0000718; GO:0046403; GO:0006979; GO:0009314 P18887; Q13426 "ATP binding; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; DNA damage response, detection of DNA damage; DNA-dependent DNA replication; damaged DNA binding; double-stranded DNA binding; endonuclease activity; nucleolus; nucleotide kinase activity; nucleotide-excision repair, DNA damage removal; polynucleotide 3'-phosphatase activity; response to oxidative stress; response to radiation" IPR000253; IPR023214; IPR006549; IPR027417; IPR013954; IPR006550; IPR006551; IPR008984; Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] PNKP Homo sapiens (Human) TR43007_c2_g2_i2 P21286 Y033_NPVAC 7.00E-27 IPR023214; IPR006549; IPR013954; IPR006551; Uncharacterized 20.8 kDa protein in FGF-VUBI intergenic region (ORF 1) Autographa californica nuclear polyhedrosis virus (AcMNPV) TR43008_c0_g2_i1 Q24020 FLII_DROME 0 GO:0003779; GO:0007527; GO:0007629; GO:0010004; GO:0030239 actin binding; adult somatic muscle development; flight behavior; gastrulation involving germ band extension; myofibril assembly IPR007123; IPR001611; IPR025875; IPR003591; IPR007122; Protein flightless-1 (Flightless-I) fliI CG1484 Drosophila melanogaster (Fruit fly) TR43008_c0_g2_i3 Q24020 FLII_DROME 0 GO:0003779; GO:0007527; GO:0007629; GO:0010004; GO:0030239 actin binding; adult somatic muscle development; flight behavior; gastrulation involving germ band extension; myofibril assembly IPR007123; IPR001611; IPR025875; IPR003591; IPR007122; Protein flightless-1 (Flightless-I) fliI CG1484 Drosophila melanogaster (Fruit fly) TR43008_c0_g2_i4 Q6DHL5 LRC57_DANRE 1.00E-08 IPR001611; IPR025875; Leucine-rich repeat-containing protein 57 lrrc57 zgc:92240 Danio rerio (Zebrafish) (Brachydanio rerio) TR43008_c0_g2_i6 Q24020 FLII_DROME 0 GO:0003779; GO:0007527; GO:0007629; GO:0010004; GO:0030239 actin binding; adult somatic muscle development; flight behavior; gastrulation involving germ band extension; myofibril assembly IPR007123; IPR001611; IPR025875; IPR003591; IPR007122; Protein flightless-1 (Flightless-I) fliI CG1484 Drosophila melanogaster (Fruit fly) TR43009_c0_g2_i4 Q9VRP9 BRE1_DROME 2.00E-141 GO:0007219; GO:0016574; GO:0016874; GO:0005634; GO:0006909; GO:0006513; GO:0008270 Notch signaling pathway; histone ubiquitination; ligase activity; nucleus; phagocytosis; protein monoubiquitination; zinc ion binding IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase Bre1 (EC 6.3.2.-) (dBre1) Bre1 CG10542 Drosophila melanogaster (Fruit fly) TR43009_c0_g2_i5 Q9VRP9 BRE1_DROME 8.00E-84 GO:0007219; GO:0016574; GO:0016874; GO:0005634; GO:0006909; GO:0006513; GO:0008270 Notch signaling pathway; histone ubiquitination; ligase activity; nucleus; phagocytosis; protein monoubiquitination; zinc ion binding IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase Bre1 (EC 6.3.2.-) (dBre1) Bre1 CG10542 Drosophila melanogaster (Fruit fly) TR43009_c0_g2_i6 Q8RXD6 BRE1A_ARATH 7.00E-19 GO:0051301; GO:0016049; GO:0009817; GO:0033523; GO:0010390; GO:0009965; GO:0005739; GO:0005634; GO:0010389; GO:0010162; GO:0004842; GO:0010228; GO:0008270 Q6ID77 "cell division; cell growth; defense response to fungus, incompatible interaction; histone H2B ubiquitination; histone monoubiquitination; leaf morphogenesis; mitochondrion; nucleus; regulation of G2/M transition of mitotic cell cycle; seed dormancy process; ubiquitin-protein ligase activity; vegetative to reproductive phase transition of meristem; zinc ion binding" IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase BRE1-like 1 (AtBRE1) (EC 6.3.2.-) (Protein HISTONE MONOUBIQUITINATION 1) (AtHUB1) HUB1 BRE1A At2g44950/At2g44960 T13E15.24/T13E15.23 T14P1.25/T14P1.24 Arabidopsis thaliana (Mouse-ear cress) TR43012_c1_g1_i1 P41366 VMO1_CHICK 2.00E-16 GO:0005576; GO:0030704 extracellular region; vitelline membrane formation IPR005515; Vitelline membrane outer layer protein 1 (VMO-1) (VMO-I) (VMOI) VMO1 Gallus gallus (Chicken) TR43012_c1_g1_i4 P41366 VMO1_CHICK 5.00E-30 GO:0005576; GO:0030704 extracellular region; vitelline membrane formation IPR005515; Vitelline membrane outer layer protein 1 (VMO-1) (VMO-I) (VMOI) VMO1 Gallus gallus (Chicken) TR43012_c2_g1_i2 Q27274 RO60_CAEEL 2.00E-81 GO:0003723; GO:0005737; GO:0046872; GO:0030529 RNA binding; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein homolog rop-1 C12D8.11 Caenorhabditis elegans TR43012_c2_g1_i3 P10155 RO60_HUMAN 3.00E-114 GO:0003723; GO:0060271; GO:0005737; GO:0046872; GO:0005634; GO:0030529; GO:0006383 Q9UHX1 RNA binding; cilium morphogenesis; cytoplasm; metal ion binding; nucleus; ribonucleoprotein complex; transcription from RNA polymerase III promoter IPR008858; IPR018698; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) TR43013_c2_g3_i1 Q9YH33 ESR1_ORENI 1.00E-45 GO:0030284; GO:0005634; GO:0043565; GO:0003700; GO:0005496; GO:0006351; GO:0008270 "estrogen receptor activity; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid binding; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR024178; IPR001292; IPR001723; IPR001628; IPR013088; Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) esr1 esr nr3a1 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) TR43013_c2_g3_i2 Q53AD2 ESR1_FELCA 2.00E-61 GO:0005794; GO:0071392; GO:0007204; GO:0030284; GO:0030518; GO:0043124; GO:0043433; GO:0005634; GO:0007200; GO:0005886; GO:0045429; GO:0051000; GO:0010863; GO:0051091; GO:0043565; GO:0003700; GO:0005496; GO:0006351; GO:0008270 "Golgi apparatus; cellular response to estradiol stimulus; elevation of cytosolic calcium ion concentration; estrogen receptor activity; intracellular steroid hormone receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of sequence-specific DNA binding transcription factor activity; nucleus; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of phospholipase C activity; positive regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid binding; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR024178; IPR001292; IPR024736; IPR001723; IPR001628; IPR013088; Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) ESR1 ESR NR3A1 Felis catus (Cat) (Felis silvestris catus) TR43013_c2_g3_i3 P62510 ERR3_RAT 6.00E-114 GO:0050682; GO:0005634; GO:0045893; GO:0003708; GO:0043565; GO:0005496; GO:0003707; GO:0008270 "AF-2 domain binding; nucleus; positive regulation of transcription, DNA-dependent; retinoic acid receptor activity; sequence-specific DNA binding; steroid binding; steroid hormone receptor activity; zinc ion binding" IPR008946; IPR000536; IPR027289; IPR024178; IPR003078; IPR001723; IPR001628; IPR013088; Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3) Esrrg Errg Nr3b3 Rattus norvegicus (Rat) TR43013_c2_g3_i4 Q9YH33 ESR1_ORENI 1.00E-45 GO:0030284; GO:0005634; GO:0043565; GO:0003700; GO:0005496; GO:0006351; GO:0008270 "estrogen receptor activity; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid binding; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR000536; IPR024178; IPR001292; IPR001723; IPR001628; IPR013088; Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) esr1 esr nr3a1 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) TR43013_c2_g3_i5 P62510 ERR3_RAT 5.00E-114 GO:0050682; GO:0005634; GO:0045893; GO:0003708; GO:0043565; GO:0005496; GO:0003707; GO:0008270 "AF-2 domain binding; nucleus; positive regulation of transcription, DNA-dependent; retinoic acid receptor activity; sequence-specific DNA binding; steroid binding; steroid hormone receptor activity; zinc ion binding" IPR008946; IPR000536; IPR027289; IPR024178; IPR003078; IPR001723; IPR001628; IPR013088; Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3) Esrrg Errg Nr3b3 Rattus norvegicus (Rat) TR43018_c1_g1_i2 P51611 HCFC1_MESAU 0 GO:0071339; GO:0048188; GO:0007049; GO:0003682; GO:0005737; GO:0043984; GO:0043981; GO:0043982; GO:0000123; GO:0000122; GO:0043025; GO:0045931; GO:0050821; GO:0003713 MLL1 complex; Set1C/COMPASS complex; cell cycle; chromatin binding; cytoplasm; histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase complex; negative regulation of transcription from RNA polymerase II promoter; neuronal cell body; positive regulation of mitotic cell cycle; protein stabilization; transcription coactivator activity IPR003961; IPR013783; IPR015915; IPR006652; Host cell factor 1 (HCF) (HCF-1) (C1 factor) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] HCFC1 Mesocricetus auratus (Golden hamster) TR43018_c1_g1_i3 Q9V4C8 HCF_DROME 4.00E-175 GO:0044666; GO:0048188; GO:0007049; GO:0003682; GO:0006338; GO:0043966; GO:0051568; GO:0043967; GO:0000123; GO:0045927; GO:0045893; GO:0003713 Q5LJZ2 "MLL3/4 complex; Set1C/COMPASS complex; cell cycle; chromatin binding; chromatin remodeling; histone H3 acetylation; histone H3-K4 methylation; histone H4 acetylation; histone acetyltransferase complex; positive regulation of growth; positive regulation of transcription, DNA-dependent; transcription coactivator activity" IPR003961; IPR015916; IPR013783; IPR015915; IPR006652; Host cell factor (dHcf) [Cleaved into: HCF N-terminal chain; HCF C-terminal chain] Hcf CG1710 Drosophila melanogaster (Fruit fly) TR43018_c1_g5_i1 Q61191 HCFC1_MOUSE 1.00E-89 GO:0005671; GO:0071339; GO:0070688; GO:0001205; GO:0070461; GO:0048188; GO:0007049; GO:0003682; GO:0005737; GO:0043984; GO:0043981; GO:0043982; GO:0046972; GO:0043995; GO:0043996; GO:0000123; GO:0005739; GO:0000122; GO:0043025; GO:0050821; GO:0043254; GO:0019046; GO:0003713 Ada2/Gcn5/Ada3 transcription activator complex; MLL1 complex; MLL5-L complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; SAGA-type complex; Set1C/COMPASS complex; cell cycle; chromatin binding; cytoplasm; histone H4-K16 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; histone acetyltransferase activity (H4-K16 specific); histone acetyltransferase activity (H4-K5 specific); histone acetyltransferase activity (H4-K8 specific); histone acetyltransferase complex; mitochondrion; negative regulation of transcription from RNA polymerase II promoter; neuronal cell body; protein stabilization; regulation of protein complex assembly; release from viral latency; transcription coactivator activity IPR003961; IPR013783; IPR015915; IPR006652; Host cell factor 1 (HCF) (HCF-1) (C1 factor) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] Hcfc1 Mus musculus (Mouse) TR43019_c2_g2_i1 P59470 RPC2_MOUSE 0 GO:0003677; GO:0005666; GO:0003899; GO:0051607; GO:0045087; GO:0046872; GO:0045089; GO:0032728; GO:0032549; GO:0006351 "DNA binding; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase activity; defense response to virus; innate immune response; metal ion binding; positive regulation of innate immune response; positive regulation of interferon-beta production; ribonucleoside binding; transcription, DNA-dependent" IPR015712; IPR007120; IPR007121; IPR007644; IPR007642; IPR007645; IPR007646; IPR007647; IPR007641; IPR014724; DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B) Polr3b Mus musculus (Mouse) TR4302_c0_g1_i1 P02712 ACHB_TORCA 1.00E-09 GO:0004889; GO:0030054; GO:0016021; GO:0045211 acetylcholine-activated cation-selective channel activity; cell junction; integral to membrane; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit beta CHRNB1 Torpedo californica (Pacific electric ray) TR4302_c0_g2_i1 P19370 ACHB2_CARAU 1.00E-09 GO:0042166; GO:0015464; GO:0004889; GO:0005892; GO:0035095; GO:0030054; GO:0007613; GO:0045211; GO:0001666; GO:0008542 acetylcholine binding; acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; behavioral response to nicotine; cell junction; memory; postsynaptic membrane; response to hypoxia; visual learning IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit beta-2 (GF-beta-2) (Fragment) chrnb2 Carassius auratus (Goldfish) TR43021_c0_g1_i2 Q6PFQ2 EIF3C_DANRE 0 GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0006446; GO:0003743; GO:0006413 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; regulation of translational initiation; translation initiation factor activity; translational initiation IPR016024; IPR027516; IPR008905; IPR000717; IPR011991; Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) eif3c eif3s8 Danio rerio (Zebrafish) (Brachydanio rerio) TR43021_c0_g1_i3 Q9D554 SF3A3_MOUSE 4.00E-145 GO:0008380; GO:0071013; GO:0006397; GO:0003676; GO:0008270 RNA splicing; catalytic step 2 spliceosome; mRNA processing; nucleic acid binding; zinc ion binding IPR024598; IPR021966; IPR015880; IPR000690; Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61) Sf3a3 Sap61 Mus musculus (Mouse) TR43021_c0_g1_i4 O46106 NOI_DROME 3.00E-115 GO:0005686; GO:0071013; GO:0009566; GO:0000398; GO:0007067; GO:0007052; GO:0003676; GO:0051533; GO:0071011; GO:0051726; GO:0008270 "U2 snRNP; catalytic step 2 spliceosome; fertilization; mRNA splicing, via spliceosome; mitosis; mitotic spindle organization; nucleic acid binding; positive regulation of NFAT protein import into nucleus; precatalytic spliceosome; regulation of cell cycle; zinc ion binding" IPR024598; IPR021966; IPR015880; IPR000690; Splicing factor 3A subunit 3 (Protein noisette) noi CG2925 Drosophila melanogaster (Fruit fly) TR43021_c0_g1_i5 Q9D554 SF3A3_MOUSE 1.00E-65 GO:0008380; GO:0071013; GO:0006397; GO:0003676; GO:0008270 RNA splicing; catalytic step 2 spliceosome; mRNA processing; nucleic acid binding; zinc ion binding IPR024598; IPR021966; IPR015880; IPR000690; Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61) Sf3a3 Sap61 Mus musculus (Mouse) TR43022_c1_g1_i2 Q7ZYZ6 DLGP1_DANRE 2.00E-22 GO:0030054; GO:0007267; GO:0014069; GO:0045211 cell junction; cell-cell signaling; postsynaptic density; postsynaptic membrane IPR005026; Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) dlgap1 si:zc142h2.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR43024_c0_g6_i1 Q37145 ACA1_ARATH 1.00E-149 GO:0005524; GO:0005262; GO:0005388; GO:0009706; GO:0005783; GO:0016021; GO:0046872; GO:0005886 ATP binding; calcium channel activity; calcium-transporting ATPase activity; chloroplast inner membrane; endoplasmic reticulum; integral to membrane; metal ion binding; plasma membrane IPR006408; IPR006068; IPR004014; IPR023299; IPR018303; IPR023298; IPR008250; IPR024750; IPR001757; IPR023214; "Calcium-transporting ATPase 1, chloroplastic (EC 3.6.3.8) (Ca(2+)-ATPase isoform 1) (Plastid envelope ATPase 1)" ACA1 PEA1 At1g27770 F28L5.1 T22C5.23 Arabidopsis thaliana (Mouse-ear cress) TR43024_c0_g6_i2 Q64542 AT2B4_RAT 0 GO:0005524; GO:0016323; GO:1901660; GO:0005388; GO:0006874; GO:0021766; GO:0016021; GO:0046872; GO:0003407; GO:0043005; GO:0097228; GO:0007283 ATP binding; basolateral plasma membrane; calcium ion export; calcium-transporting ATPase activity; cellular calcium ion homeostasis; hippocampus development; integral to membrane; metal ion binding; neural retina development; neuron projection; sperm principal piece; spermatogenesis IPR022141; IPR006408; IPR006068; IPR004014; IPR023299; IPR018303; IPR023298; IPR008250; IPR001757; IPR023214; Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 3.6.3.8) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) Atp2b4 Rattus norvegicus (Rat) TR43024_c0_g6_i3 Q64542 AT2B4_RAT 0 GO:0005524; GO:0016323; GO:1901660; GO:0005388; GO:0006874; GO:0021766; GO:0016021; GO:0046872; GO:0003407; GO:0043005; GO:0097228; GO:0007283 ATP binding; basolateral plasma membrane; calcium ion export; calcium-transporting ATPase activity; cellular calcium ion homeostasis; hippocampus development; integral to membrane; metal ion binding; neural retina development; neuron projection; sperm principal piece; spermatogenesis IPR022141; IPR006408; IPR006068; IPR004014; IPR023299; IPR018303; IPR023298; IPR008250; IPR001757; IPR023214; Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 3.6.3.8) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) Atp2b4 Rattus norvegicus (Rat) TR43024_c0_g6_i4 Q37145 ACA1_ARATH 1.00E-150 GO:0005524; GO:0005262; GO:0005388; GO:0009706; GO:0005783; GO:0016021; GO:0046872; GO:0005886 ATP binding; calcium channel activity; calcium-transporting ATPase activity; chloroplast inner membrane; endoplasmic reticulum; integral to membrane; metal ion binding; plasma membrane IPR006408; IPR006068; IPR004014; IPR023299; IPR018303; IPR023298; IPR008250; IPR024750; IPR001757; IPR023214; "Calcium-transporting ATPase 1, chloroplastic (EC 3.6.3.8) (Ca(2+)-ATPase isoform 1) (Plastid envelope ATPase 1)" ACA1 PEA1 At1g27770 F28L5.1 T22C5.23 Arabidopsis thaliana (Mouse-ear cress) TR43025_c2_g1_i1 Q6NZN0 RBM26_MOUSE 4.00E-30 GO:0003723; GO:0006397; GO:0046872; GO:0010923; GO:0000166 RNA binding; mRNA processing; metal ion binding; negative regulation of phosphatase activity; nucleotide binding IPR012677; IPR002483; IPR000504; IPR000571; RNA-binding protein 26 (Protein expressed in male leptotene and zygotene spermatocytes 393) (MLZ-393) (RNA-binding motif protein 26) Rbm26 Mus musculus (Mouse) TR43025_c2_g3_i2 Q2T9I5 RBM26_XENLA 5.00E-24 GO:0003723; GO:0006397; GO:0046872; GO:0010923; GO:0000166 RNA binding; mRNA processing; metal ion binding; negative regulation of phosphatase activity; nucleotide binding IPR012677; IPR002483; IPR000504; IPR000571; RNA-binding protein 26 (RNA-binding motif protein 26) rbm26 Xenopus laevis (African clawed frog) TR43025_c2_g4_i1 Q2T9I5 RBM26_XENLA 3.00E-18 GO:0003723; GO:0006397; GO:0046872; GO:0010923; GO:0000166 RNA binding; mRNA processing; metal ion binding; negative regulation of phosphatase activity; nucleotide binding IPR012677; IPR002483; IPR000504; IPR000571; RNA-binding protein 26 (RNA-binding motif protein 26) rbm26 Xenopus laevis (African clawed frog) TR43026_c2_g1_i5 Q8BKE6 CP20A_MOUSE 5.00E-80 GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705 "heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR002401; Cytochrome P450 20A1 (EC 1.14.-.-) Cyp20a1 Mus musculus (Mouse) TR43026_c2_g1_i6 Q6ZWL3 CP4V2_HUMAN 9.00E-26 GO:0005789; GO:0010430; GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705; GO:0050896; GO:0007601 "endoplasmic reticulum membrane; fatty acid omega-oxidation; heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; response to stimulus; visual perception" IPR001128; IPR017972; IPR002401; Cytochrome P450 4V2 (EC 1.14.13.-) CYP4V2 Homo sapiens (Human) TR43026_c2_g1_i8 Q8BKE6 CP20A_MOUSE 4.00E-80 GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705 "heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR002401; Cytochrome P450 20A1 (EC 1.14.-.-) Cyp20a1 Mus musculus (Mouse) TR43027_c0_g1_i1 P04920 B3A2_HUMAN 0 GO:0008509; GO:0016323; GO:0015701; GO:0015108; GO:0005452; GO:0016021; GO:0005886 anion transmembrane transporter activity; basolateral plasma membrane; bicarbonate transport; chloride transmembrane transporter activity; inorganic anion exchanger activity; integral to membrane; plasma membrane IPR001717; IPR002978; IPR018241; IPR013769; IPR011531; IPR003020; IPR016152; Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) SLC4A2 AE2 EPB3L1 HKB3 MPB3L Homo sapiens (Human) TR43027_c0_g1_i6 P02730 B3AT_HUMAN 1.00E-121 GO:0030018; GO:0016323; GO:0015701; GO:0006873; GO:0015108; GO:0030863; GO:0005452; GO:0005887; GO:0043495; GO:0044281 Z disc; basolateral plasma membrane; bicarbonate transport; cellular ion homeostasis; chloride transmembrane transporter activity; cortical cytoskeleton; inorganic anion exchanger activity; integral to plasma membrane; protein anchor; small molecule metabolic process IPR001717; IPR002977; IPR018241; IPR013769; IPR011531; IPR003020; IPR016152; Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) SLC4A1 AE1 DI EPB3 Homo sapiens (Human) TR43027_c0_g1_i7 P04920 B3A2_HUMAN 1.00E-153 GO:0008509; GO:0016323; GO:0015701; GO:0015108; GO:0005452; GO:0016021; GO:0005886 anion transmembrane transporter activity; basolateral plasma membrane; bicarbonate transport; chloride transmembrane transporter activity; inorganic anion exchanger activity; integral to membrane; plasma membrane IPR001717; IPR002978; IPR018241; IPR013769; IPR011531; IPR003020; IPR016152; Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) SLC4A2 AE2 EPB3L1 HKB3 MPB3L Homo sapiens (Human) TR43027_c0_g2_i2 Q9BRP4 PAAF1_HUMAN 1.00E-37 GO:0019048; GO:0000502 P62195 modulation by virus of host morphology or physiology; proteasome complex IPR020472; IPR015943; IPR001680; IPR019775; IPR017986; Proteasomal ATPase-associated factor 1 (Protein G-16) (WD repeat-containing protein 71) PAAF1 WDR71 Homo sapiens (Human) TR43028_c1_g1_i2 P78789 YC63_SCHPO 5.00E-08 GO:0031588; GO:0042149; GO:0005829; GO:0005634; GO:0005886; GO:0019887; GO:0007165 AMP-activated protein kinase complex; cellular response to glucose starvation; cytosol; nucleus; plasma membrane; protein kinase regulator activity; signal transduction IPR006828; IPR014756; Uncharacterized protein C1919.03c SPCC1919.03c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR43028_c1_g1_i8 P78789 YC63_SCHPO 4.00E-08 GO:0031588; GO:0042149; GO:0005829; GO:0005634; GO:0005886; GO:0019887; GO:0007165 AMP-activated protein kinase complex; cellular response to glucose starvation; cytosol; nucleus; plasma membrane; protein kinase regulator activity; signal transduction IPR006828; IPR014756; Uncharacterized protein C1919.03c SPCC1919.03c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR43029_c0_g1_i1 Q2PFW9 NOVA1_MACFA 8.00E-63 GO:0003723; GO:0005634 RNA binding; nucleus IPR004087; IPR004088; RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Ventral neuron-specific protein 1) NOVA1 QflA-17531 QtsA-14227 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR43029_c0_g1_i2 Q9JKN6 NOVA1_MOUSE 3.00E-59 GO:0003729; GO:0000398; GO:0005634 "mRNA binding; mRNA splicing, via spliceosome; nucleus" IPR004087; IPR004088; RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Ventral neuron-specific protein 1) Nova1 Mus musculus (Mouse) TR43031_c1_g1_i1 Q22888 IF4E4_CAEEL 4.00E-21 GO:0005737; GO:0006417; GO:0003743 cytoplasm; regulation of translation; translation initiation factor activity IPR023398; IPR001040; IPR019770; Eukaryotic translation initiation factor 4E-4 (eIF-4E-4) (eIF4E-4) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) ife-4 C05D9.5 Caenorhabditis elegans TR43031_c1_g1_i11 O77210 IF4E_APLCA 9.00E-89 GO:0005737; GO:0006417; GO:0003743 cytoplasm; regulation of translation; translation initiation factor activity IPR023398; IPR001040; IPR019770; Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) Aplysia californica (California sea hare) TR43031_c1_g1_i3 O77210 IF4E_APLCA 2.00E-85 GO:0005737; GO:0006417; GO:0003743 cytoplasm; regulation of translation; translation initiation factor activity IPR023398; IPR001040; IPR019770; Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) Aplysia californica (California sea hare) TR43031_c1_g1_i8 O77210 IF4E_APLCA 2.00E-86 GO:0005737; GO:0006417; GO:0003743 cytoplasm; regulation of translation; translation initiation factor activity IPR023398; IPR001040; IPR019770; Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) Aplysia californica (California sea hare) TR43033_c3_g2_i1 Q92125 ANXA7_XENLA 3.00E-112 GO:0005509; GO:0005544 calcium ion binding; calcium-dependent phospholipid binding IPR001464; IPR018502; IPR018252; IPR013286; Annexin A7 (Annexin VII) (Annexin-7) (Synexin) anxa7 anx7 Xenopus laevis (African clawed frog) TR43033_c3_g2_i11 P20072 ANXA7_BOVIN 1.00E-130 GO:0005509; GO:0005544; GO:0008283; GO:0006874; GO:0009992; GO:0042584; GO:0005829; GO:0005789; GO:0007599; GO:0005635; GO:0005886; GO:0008360; GO:0009651; GO:0035176 calcium ion binding; calcium-dependent phospholipid binding; cell proliferation; cellular calcium ion homeostasis; cellular water homeostasis; chromaffin granule membrane; cytosol; endoplasmic reticulum membrane; hemostasis; nuclear envelope; plasma membrane; regulation of cell shape; response to salt stress; social behavior IPR001464; IPR018502; IPR018252; IPR013286; Annexin A7 (Annexin VII) (Annexin-7) (Synexin) ANXA7 ANX7 Bos taurus (Bovine) TR43033_c3_g2_i12 Q92125 ANXA7_XENLA 4.00E-110 GO:0005509; GO:0005544 calcium ion binding; calcium-dependent phospholipid binding IPR001464; IPR018502; IPR018252; IPR013286; Annexin A7 (Annexin VII) (Annexin-7) (Synexin) anxa7 anx7 Xenopus laevis (African clawed frog) TR43033_c3_g2_i13 Q92108 ANXA1_CHICK 8.00E-18 GO:0016323; GO:0005509; GO:0005544; GO:0005929; GO:0005737; GO:0005634; GO:0019834 basolateral plasma membrane; calcium ion binding; calcium-dependent phospholipid binding; cilium; cytoplasm; nucleus; phospholipase A2 inhibitor activity IPR001464; IPR018502; IPR018252; IPR002388; Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) (Fragment) ANXA1 ANX1 Gallus gallus (Chicken) TR43033_c3_g2_i14 P24639 ANXA7_DICDI 2.00E-65 GO:0005509; GO:0005544; GO:0006874; GO:0010008; GO:0005634; GO:0045335; GO:0005886; GO:0009617; GO:0030587 calcium ion binding; calcium-dependent phospholipid binding; cellular calcium ion homeostasis; endosome membrane; nucleus; phagocytic vesicle; plasma membrane; response to bacterium; sorocarp development IPR001464; IPR018502; IPR018252; Annexin A7 (Annexin VII) (Annexin-7) (Synexin) nxnA ann7 DDB_G0269160 Dictyostelium discoideum (Slime mold) TR43033_c3_g2_i17 P20072 ANXA7_BOVIN 1.00E-127 GO:0005509; GO:0005544; GO:0008283; GO:0006874; GO:0009992; GO:0042584; GO:0005829; GO:0005789; GO:0007599; GO:0005635; GO:0005886; GO:0008360; GO:0009651; GO:0035176 calcium ion binding; calcium-dependent phospholipid binding; cell proliferation; cellular calcium ion homeostasis; cellular water homeostasis; chromaffin granule membrane; cytosol; endoplasmic reticulum membrane; hemostasis; nuclear envelope; plasma membrane; regulation of cell shape; response to salt stress; social behavior IPR001464; IPR018502; IPR018252; IPR013286; Annexin A7 (Annexin VII) (Annexin-7) (Synexin) ANXA7 ANX7 Bos taurus (Bovine) TR43033_c3_g2_i3 Q5R5A0 ANXA2_PONAB 2.00E-87 GO:0043220; GO:0005604; GO:0005509; GO:0005544; GO:0070062; GO:0005811; GO:0030496; GO:0035749; GO:0004859; GO:0031340 Schmidt-Lanterman incisure; basement membrane; calcium ion binding; calcium-dependent phospholipid binding; extracellular vesicular exosome; lipid particle; midbody; myelin sheath adaxonal region; phospholipase inhibitor activity; positive regulation of vesicle fusion IPR001464; IPR018502; IPR018252; IPR002389; Annexin A2 (Annexin-2) ANXA2 ANX2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR43033_c3_g2_i4 P20072 ANXA7_BOVIN 4.00E-129 GO:0005509; GO:0005544; GO:0008283; GO:0006874; GO:0009992; GO:0042584; GO:0005829; GO:0005789; GO:0007599; GO:0005635; GO:0005886; GO:0008360; GO:0009651; GO:0035176 calcium ion binding; calcium-dependent phospholipid binding; cell proliferation; cellular calcium ion homeostasis; cellular water homeostasis; chromaffin granule membrane; cytosol; endoplasmic reticulum membrane; hemostasis; nuclear envelope; plasma membrane; regulation of cell shape; response to salt stress; social behavior IPR001464; IPR018502; IPR018252; IPR013286; Annexin A7 (Annexin VII) (Annexin-7) (Synexin) ANXA7 ANX7 Bos taurus (Bovine) TR43033_c3_g2_i6 Q9SYT0 ANXD1_ARATH 1.00E-47 GO:0005524; GO:0048046; GO:0005509; GO:0070588; GO:0005544; GO:0005618; GO:0009570; GO:0005507; GO:0005829; GO:0005739; GO:0004601; GO:0005886; GO:0009506; GO:0071435; GO:0042803; GO:0009737; GO:0046686; GO:0009409; GO:0009408; GO:0006979; GO:0009651; GO:0009414; GO:0009579; GO:0005774; GO:0008270 ATP binding; apoplast; calcium ion binding; calcium ion transmembrane transport; calcium-dependent phospholipid binding; cell wall; chloroplast stroma; copper ion binding; cytosol; mitochondrion; peroxidase activity; plasma membrane; plasmodesma; potassium ion export; protein homodimerization activity; response to abscisic acid stimulus; response to cadmium ion; response to cold; response to heat; response to oxidative stress; response to salt stress; response to water deprivation; thylakoid; vacuolar membrane; zinc ion binding IPR001464; IPR009118; IPR018502; IPR018252; Annexin D1 (AnnAt1) (Annexin A1) ANN1 ANNAT1 ANX23-ATH ATOXY5 OXY5 At1g35720 F14D7.2 Arabidopsis thaliana (Mouse-ear cress) TR43033_c3_g2_i7 P22465 ANX10_DROME 2.00E-98 GO:0003779; GO:0005509; GO:0005544; GO:0016020 actin binding; calcium ion binding; calcium-dependent phospholipid binding; membrane IPR001464; IPR018502; IPR018252; Annexin-B10 (Annexin X) (Annexin-10) AnnX CG9579 Drosophila melanogaster (Fruit fly) TR43033_c3_g2_i9 P24639 ANXA7_DICDI 2.00E-65 GO:0005509; GO:0005544; GO:0006874; GO:0010008; GO:0005634; GO:0045335; GO:0005886; GO:0009617; GO:0030587 calcium ion binding; calcium-dependent phospholipid binding; cellular calcium ion homeostasis; endosome membrane; nucleus; phagocytic vesicle; plasma membrane; response to bacterium; sorocarp development IPR001464; IPR018502; IPR018252; Annexin A7 (Annexin VII) (Annexin-7) (Synexin) nxnA ann7 DDB_G0269160 Dictyostelium discoideum (Slime mold) TR43035_c0_g2_i2 O70546 KDM6A_MOUSE 2.00E-178 GO:0000978; GO:0060070; GO:0051213; GO:0007507; GO:0071558; GO:0035097; GO:0001701; GO:0048333; GO:0046872; GO:0001843; GO:0048570; GO:0003016; GO:0032525 Q61321 RNA polymerase II core promoter proximal region sequence-specific DNA binding; canonical Wnt receptor signaling pathway; dioxygenase activity; heart development; histone demethylase activity (H3-K27 specific); histone methyltransferase complex; in utero embryonic development; mesodermal cell differentiation; metal ion binding; neural tube closure; notochord morphogenesis; respiratory system process; somite rostral/caudal axis specification IPR003347; IPR013026; IPR011990; IPR001440; IPR019734; Lysine-specific demethylase 6A (EC 1.14.11.-) (Histone demethylase UTX) (Ubiquitously transcribed TPR protein on the X chromosome) (Ubiquitously transcribed X chromosome tetratricopeptide repeat protein) Kdm6a Utx Mus musculus (Mouse) TR43036_c1_g1_i2 Q99715 COCA1_HUMAN 9.00E-26 GO:0007155; GO:0030574; GO:0030199; GO:0005595; GO:0005788; GO:0022617; GO:0030020; GO:0005615; GO:0070062; GO:0001501 cell adhesion; collagen catabolic process; collagen fibril organization; collagen type XII; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular matrix structural constituent conferring tensile strength; extracellular space; extracellular vesicular exosome; skeletal system development IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) TR43036_c1_g1_i3 Q60847 COCA1_MOUSE 1.00E-24 GO:0007155; GO:0005581; GO:0005615; GO:0070062 cell adhesion; collagen; extracellular space; extracellular vesicular exosome IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain Col12a1 Mus musculus (Mouse) TR43037_c3_g1_i1 P43304 GPDM_HUMAN 1.00E-12 GO:0005509; GO:0044255; GO:0006094; GO:0019563; GO:0004368; GO:0009331; GO:0006072; GO:0005743; GO:0044281; GO:0052591 calcium ion binding; cellular lipid metabolic process; gluconeogenesis; glycerol catabolic process; glycerol-3-phosphate dehydrogenase activity; glycerol-3-phosphate dehydrogenase complex; glycerol-3-phosphate metabolic process; mitochondrial inner membrane; small molecule metabolic process; sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity IPR011992; IPR018247; IPR002048; IPR006076; IPR000447; Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1. "Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD-M) (GPDH-M) (EC 1.1.5.3) (mtGPD)" GPD2 Homo sapiens (Human) TR43037_c3_g1_i6 A6QLU1 GPDM_BOVIN 0 GO:0005509; GO:0006094; GO:0019563; GO:0009331; GO:0006072; GO:0005743; GO:0052591 calcium ion binding; gluconeogenesis; glycerol catabolic process; glycerol-3-phosphate dehydrogenase complex; glycerol-3-phosphate metabolic process; mitochondrial inner membrane; sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity IPR011992; IPR018247; IPR002048; IPR006076; IPR000447; Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (aerobic route): step 1/1. "Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD-M) (GPDH-M) (EC 1.1.5.3)" GPD2 Bos taurus (Bovine) TR43038_c0_g1_i3 Q9ULB1 NRX1A_HUMAN 6.00E-94 GO:0033130; GO:0030534; GO:0007411; GO:0005246; GO:0005509; GO:0007155; GO:0050839; GO:0030054; GO:0009986; GO:0030198; GO:0097116; GO:0005887; GO:0007612; GO:0097118; GO:0097109; GO:0050885; GO:0007269; GO:2000463; GO:0051965; GO:0090129; GO:0051968; GO:0097119; GO:0097104; GO:0060134; GO:0042734; GO:0004872; GO:2000821; GO:0035176; GO:0071625 "acetylcholine receptor binding; adult behavior; axon guidance; calcium channel regulator activity; calcium ion binding; cell adhesion; cell adhesion molecule binding; cell junction; cell surface; extracellular matrix organization; gephyrin clustering; integral to plasma membrane; learning; neuroligin clustering; neuroligin family protein binding; neuromuscular process controlling balance; neurotransmitter secretion; positive regulation of excitatory postsynaptic membrane potential; positive regulation of synapse assembly; positive regulation of synapse maturation; positive regulation of synaptic transmission, glutamatergic; postsynaptic density protein 95 clustering; postsynaptic membrane assembly; prepulse inhibition; presynaptic membrane; receptor activity; regulation of grooming behavior; social behavior; vocalization behavior" IPR008985; IPR013320; IPR000742; IPR000152; IPR001791; IPR003585; IPR027158; IPR027789; Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) NRXN1 KIAA0578 Homo sapiens (Human) TR43038_c0_g1_i4 Q9CS84 NRX1A_MOUSE 4.00E-91 GO:0033130; GO:0030534; GO:0005246; GO:0005509; GO:0007155; GO:0030054; GO:0009986; GO:0097116; GO:0016021; GO:0007612; GO:0097118; GO:0050885; GO:0007269; GO:2000463; GO:0051965; GO:0090129; GO:0051968; GO:0097119; GO:0097104; GO:0060134; GO:0042734; GO:2000821 O14522 "acetylcholine receptor binding; adult behavior; calcium channel regulator activity; calcium ion binding; cell adhesion; cell junction; cell surface; gephyrin clustering; integral to membrane; learning; neuroligin clustering; neuromuscular process controlling balance; neurotransmitter secretion; positive regulation of excitatory postsynaptic membrane potential; positive regulation of synapse assembly; positive regulation of synapse maturation; positive regulation of synaptic transmission, glutamatergic; postsynaptic density protein 95 clustering; postsynaptic membrane assembly; prepulse inhibition; presynaptic membrane; regulation of grooming behavior" IPR008985; IPR013320; IPR000742; IPR000152; IPR001791; IPR003585; IPR027158; IPR027789; Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) Nrxn1 Kiaa0578 Mus musculus (Mouse) TR43038_c0_g1_i5 A1XQX0 NR1AA_DANRE 2.00E-93 GO:0007155; GO:0016021; GO:0046872; GO:0007269; GO:0051965; GO:0090129; GO:0007416 cell adhesion; integral to membrane; metal ion binding; neurotransmitter secretion; positive regulation of synapse assembly; positive regulation of synapse maturation; synapse assembly IPR008985; IPR013320; IPR000742; IPR001791; IPR003585; IPR027158; IPR027789; Neurexin-1a (Neurexin Ia-alpha) (Neurexin-1a-alpha) nrxn1a Danio rerio (Zebrafish) (Brachydanio rerio) TR43038_c0_g1_i6 Q63372 NRX1A_RAT 3.00E-91 GO:0033130; GO:0030534; GO:0005246; GO:0005509; GO:0007155; GO:0050839; GO:0030054; GO:0009986; GO:0097116; GO:0016021; GO:0007612; GO:0097118; GO:0097109; GO:0050885; GO:0007269; GO:2000463; GO:0051965; GO:0090129; GO:0051968; GO:0097119; GO:0097104; GO:0060134; GO:0042734; GO:0051290; GO:2000821 "acetylcholine receptor binding; adult behavior; calcium channel regulator activity; calcium ion binding; cell adhesion; cell adhesion molecule binding; cell junction; cell surface; gephyrin clustering; integral to membrane; learning; neuroligin clustering; neuroligin family protein binding; neuromuscular process controlling balance; neurotransmitter secretion; positive regulation of excitatory postsynaptic membrane potential; positive regulation of synapse assembly; positive regulation of synapse maturation; positive regulation of synaptic transmission, glutamatergic; postsynaptic density protein 95 clustering; postsynaptic membrane assembly; prepulse inhibition; presynaptic membrane; protein heterotetramerization; regulation of grooming behavior" IPR008985; IPR013320; IPR000742; IPR000152; IPR001791; IPR003585; IPR027158; IPR027789; Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) Nrxn1 Rattus norvegicus (Rat) TR43038_c0_g1_i7 A1XQX0 NR1AA_DANRE 2.00E-93 GO:0007155; GO:0016021; GO:0046872; GO:0007269; GO:0051965; GO:0090129; GO:0007416 cell adhesion; integral to membrane; metal ion binding; neurotransmitter secretion; positive regulation of synapse assembly; positive regulation of synapse maturation; synapse assembly IPR008985; IPR013320; IPR000742; IPR001791; IPR003585; IPR027158; IPR027789; Neurexin-1a (Neurexin Ia-alpha) (Neurexin-1a-alpha) nrxn1a Danio rerio (Zebrafish) (Brachydanio rerio) TR43038_c0_g1_i8 A1XQX0 NR1AA_DANRE 2.00E-93 GO:0007155; GO:0016021; GO:0046872; GO:0007269; GO:0051965; GO:0090129; GO:0007416 cell adhesion; integral to membrane; metal ion binding; neurotransmitter secretion; positive regulation of synapse assembly; positive regulation of synapse maturation; synapse assembly IPR008985; IPR013320; IPR000742; IPR001791; IPR003585; IPR027158; IPR027789; Neurexin-1a (Neurexin Ia-alpha) (Neurexin-1a-alpha) nrxn1a Danio rerio (Zebrafish) (Brachydanio rerio) TR43040_c0_g1_i10 Q9U9K0 ADD1_CAEEL 1.00E-134 GO:0051015; GO:0051016; GO:0005737; GO:0007616; GO:0005886; GO:0014069; GO:0097120; GO:2000249; GO:0007614 actin filament binding; barbed-end actin filament capping; cytoplasm; long-term memory; plasma membrane; postsynaptic density; receptor localization to synapse; regulation of actin cytoskeleton reorganization; short-term memory IPR001303; Adducin-related protein 1 add-1 F39C12.2 Caenorhabditis elegans TR43040_c0_g1_i11 Q20952 ADD2_CAEEL 2.00E-83 GO:0005737; GO:0005856; GO:0005886 cytoplasm; cytoskeleton; plasma membrane IPR001303; Adducin-related protein 2 add-2 F57F5.4 Caenorhabditis elegans TR43040_c0_g1_i2 P35611 ADDA_HUMAN 4.00E-146 GO:0008290; GO:0051015; GO:0051017; GO:0006987; GO:0051016; GO:0000902; GO:0006884; GO:0006921; GO:0044267; GO:0071300; GO:0005829; GO:0043197; GO:0030218; GO:0020027; GO:0048873; GO:0001701; GO:0035264; GO:0005634; GO:0048471; GO:0005886; GO:0045766; GO:0045807; GO:0032092; GO:0014069; GO:0030507; GO:0005198 F-actin capping protein complex; actin filament binding; actin filament bundle assembly; activation of signaling protein activity involved in unfolded protein response; barbed-end actin filament capping; cell morphogenesis; cell volume homeostasis; cellular component disassembly involved in execution phase of apoptosis; cellular protein metabolic process; cellular response to retinoic acid; cytosol; dendritic spine; erythrocyte differentiation; hemoglobin metabolic process; homeostasis of number of cells within a tissue; in utero embryonic development; multicellular organism growth; nucleus; perinuclear region of cytoplasm; plasma membrane; positive regulation of angiogenesis; positive regulation of endocytosis; positive regulation of protein binding; postsynaptic density; spectrin binding; structural molecule activity IPR027766; IPR001303; Alpha-adducin (Erythrocyte adducin subunit alpha) ADD1 ADDA Homo sapiens (Human) TR43040_c0_g1_i3 Q02645 HTS_DROME 2.00E-86 GO:0007527; GO:0051297; GO:0007282; GO:0005856; GO:0048135; GO:0008302; GO:0035183; GO:0045169; GO:0007294; GO:0005811; GO:0000212; GO:0030723; GO:0072499; GO:0005886; GO:0045214; GO:0045170; GO:0030721; GO:0030724 Q9W0K7; Q9W0A1 "adult somatic muscle development; centrosome organization; cystoblast division; cytoskeleton; female germ-line cyst formation; female germline ring canal formation, actin assembly; female germline ring canal inner rim; fusome; germarium-derived oocyte fate determination; lipid particle; meiotic spindle organization; ovarian fusome organization; photoreceptor cell axon guidance; plasma membrane; sarcomere organization; spectrosome; spectrosome organization; testicular fusome organization" IPR001303; Protein hu-li tai shao (Adducin-like protein) hts CG9325 Drosophila melanogaster (Fruit fly) TR43040_c0_g1_i4 Q9UEY8 ADDG_HUMAN 8.00E-144 GO:0005938; GO:0005911; GO:0000794; GO:0005856; GO:0016020; GO:0005886; GO:0005200 cell cortex; cell-cell junction; condensed nuclear chromosome; cytoskeleton; membrane; plasma membrane; structural constituent of cytoskeleton IPR027772; IPR001303; Gamma-adducin (Adducin-like protein 70) ADD3 ADDL Homo sapiens (Human) TR43040_c0_g1_i6 P35611 ADDA_HUMAN 8.00E-154 GO:0008290; GO:0051015; GO:0051017; GO:0006987; GO:0051016; GO:0000902; GO:0006884; GO:0006921; GO:0044267; GO:0071300; GO:0005829; GO:0043197; GO:0030218; GO:0020027; GO:0048873; GO:0001701; GO:0035264; GO:0005634; GO:0048471; GO:0005886; GO:0045766; GO:0045807; GO:0032092; GO:0014069; GO:0030507; GO:0005198 F-actin capping protein complex; actin filament binding; actin filament bundle assembly; activation of signaling protein activity involved in unfolded protein response; barbed-end actin filament capping; cell morphogenesis; cell volume homeostasis; cellular component disassembly involved in execution phase of apoptosis; cellular protein metabolic process; cellular response to retinoic acid; cytosol; dendritic spine; erythrocyte differentiation; hemoglobin metabolic process; homeostasis of number of cells within a tissue; in utero embryonic development; multicellular organism growth; nucleus; perinuclear region of cytoplasm; plasma membrane; positive regulation of angiogenesis; positive regulation of endocytosis; positive regulation of protein binding; postsynaptic density; spectrin binding; structural molecule activity IPR027766; IPR001303; Alpha-adducin (Erythrocyte adducin subunit alpha) ADD1 ADDA Homo sapiens (Human) TR43040_c0_g1_i7 Q9U9K0 ADD1_CAEEL 3.00E-141 GO:0051015; GO:0051016; GO:0005737; GO:0007616; GO:0005886; GO:0014069; GO:0097120; GO:2000249; GO:0007614 actin filament binding; barbed-end actin filament capping; cytoplasm; long-term memory; plasma membrane; postsynaptic density; receptor localization to synapse; regulation of actin cytoskeleton reorganization; short-term memory IPR001303; Adducin-related protein 1 add-1 F39C12.2 Caenorhabditis elegans TR43040_c0_g1_i8 Q5RA10 ADDA_PONAB 6.00E-150 GO:0005737; GO:0005856; GO:0005886 cytoplasm; cytoskeleton; plasma membrane IPR027766; IPR001303; Alpha-adducin (Erythrocyte adducin subunit alpha) ADD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR43040_c0_g1_i9 Q02645 HTS_DROME 1.00E-86 GO:0007527; GO:0051297; GO:0007282; GO:0005856; GO:0048135; GO:0008302; GO:0035183; GO:0045169; GO:0007294; GO:0005811; GO:0000212; GO:0030723; GO:0072499; GO:0005886; GO:0045214; GO:0045170; GO:0030721; GO:0030724 Q9W0K7; Q9W0A1 "adult somatic muscle development; centrosome organization; cystoblast division; cytoskeleton; female germ-line cyst formation; female germline ring canal formation, actin assembly; female germline ring canal inner rim; fusome; germarium-derived oocyte fate determination; lipid particle; meiotic spindle organization; ovarian fusome organization; photoreceptor cell axon guidance; plasma membrane; sarcomere organization; spectrosome; spectrosome organization; testicular fusome organization" IPR001303; Protein hu-li tai shao (Adducin-like protein) hts CG9325 Drosophila melanogaster (Fruit fly) TR43041_c2_g1_i1 Q63155 DCC_RAT 9.00E-30 GO:0033564; GO:0006915; GO:0030424; GO:0007411; GO:0033563; GO:0032584; GO:0016021; GO:0045121; GO:0005042; GO:0001764; GO:0070374; GO:0010976; GO:0001975; GO:0021965; GO:0003713 Itself; Q8CGU4; Q9ERC8; O55005; P46777 anterior/posterior axon guidance; apoptotic process; axon; axon guidance; dorsal/ventral axon guidance; growth cone membrane; integral to membrane; membrane raft; netrin receptor activity; neuron migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron projection development; response to amphetamine; spinal cord ventral commissure morphogenesis; transcription coactivator activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR010560; Netrin receptor DCC (Tumor suppressor protein DCC) Dcc Rattus norvegicus (Rat) TR43041_c2_g1_i2 Q90610 NEO1_CHICK 5.00E-32 GO:0007155; GO:0016021; GO:0005886 cell adhesion; integral to membrane; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR010560; Neogenin (Fragment) Gallus gallus (Chicken) TR43043_c0_g1_i1 P12785 FAS_RAT 0 GO:0047451; GO:0004317; GO:0004316; GO:0004315; GO:0005794; GO:0070402; GO:0004313; GO:0004314; GO:0006084; GO:0071353; GO:0008144; GO:0047117; GO:0004319; GO:0006633; GO:0004312; GO:0042587; GO:0042470; GO:0005739; GO:0016295; GO:0004320; GO:0016296; GO:0005886; GO:0042803; GO:0008270 Itself "3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; Golgi apparatus; NADPH binding; [acyl-carrier-protein] S-acetyltransferase activity; [acyl-carrier-protein] S-malonyltransferase activity; acetyl-CoA metabolic process; cellular response to interleukin-4; drug binding; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; fatty acid biosynthetic process; fatty acid synthase activity; glycogen granule; melanosome; mitochondrion; myristoyl-[acyl-carrier-protein] hydrolase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; plasma membrane; protein homodimerization activity; zinc ion binding" IPR001227; IPR009081; IPR014043; IPR016035; IPR013149; IPR023102; IPR011032; IPR018201; IPR014031; IPR014030; IPR016036; IPR013217; IPR016040; IPR020842; IPR020843; IPR013968; IPR006162; IPR001031; IPR016039; IPR016038; Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] Fasn Rattus norvegicus (Rat) TR43043_c0_g1_i2 P19096 FAS_MOUSE 0 GO:0047451; GO:0004317; GO:0004316; GO:0004315; GO:0005794; GO:0004313; GO:0004314; GO:0071353; GO:0047117; GO:0004319; GO:0006633; GO:0042587; GO:0042470; GO:0005739; GO:0016295; GO:0004320; GO:0016296; GO:0005886; GO:0008270 "3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; Golgi apparatus; [acyl-carrier-protein] S-acetyltransferase activity; [acyl-carrier-protein] S-malonyltransferase activity; cellular response to interleukin-4; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; fatty acid biosynthetic process; glycogen granule; melanosome; mitochondrion; myristoyl-[acyl-carrier-protein] hydrolase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; plasma membrane; zinc ion binding" IPR001227; IPR009081; IPR014043; IPR016035; IPR013149; IPR023102; IPR011032; IPR018201; IPR014031; IPR014030; IPR016036; IPR013217; IPR016040; IPR020842; IPR020843; IPR013968; IPR006162; IPR001031; IPR016039; IPR016038; Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] Fasn Mus musculus (Mouse) TR43043_c0_g1_i3 P96285 PKS1_MYCTU 5.00E-23 GO:0071770; GO:0006633; GO:0008610; GO:0016491; GO:0031177; GO:0005886; GO:0016747; GO:0008270 "DIM/DIP cell wall layer assembly; fatty acid biosynthetic process; lipid biosynthetic process; oxidoreductase activity; phosphopantetheine binding; plasma membrane; transferase activity, transferring acyl groups other than amino-acyl groups; zinc ion binding" IPR001227; IPR009081; IPR014043; IPR016035; IPR013149; IPR013154; IPR011032; IPR016036; IPR016040; IPR020842; IPR020801; IPR020807; IPR020843; IPR013968; IPR020806; IPR006162; Lipid metabolism; fatty acid biosynthesis. Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks1 pks1 Rv2946c Mycobacterium tuberculosis TR43043_c0_g2_i2 Q53FA7 QORX_HUMAN 1.00E-12 GO:0006739; GO:0070402; GO:0003960; GO:0008631; GO:0048038; GO:0008270 NADP metabolic process; NADPH binding; NADPH:quinone reductase activity; intrinsic apoptotic signaling pathway in response to oxidative stress; quinone binding; zinc ion binding IPR013149; IPR013154; IPR002085; IPR011032; IPR016040; IPR014189; Quinone oxidoreductase PIG3 (EC 1.-.-.-) (Tumor protein p53-inducible protein 3) (p53-induced gene 3 protein) TP53I3 PIG3 Homo sapiens (Human) TR43043_c0_g4_i1 P12785 FAS_RAT 0 GO:0047451; GO:0004317; GO:0004316; GO:0004315; GO:0005794; GO:0070402; GO:0004313; GO:0004314; GO:0006084; GO:0071353; GO:0008144; GO:0047117; GO:0004319; GO:0006633; GO:0004312; GO:0042587; GO:0042470; GO:0005739; GO:0016295; GO:0004320; GO:0016296; GO:0005886; GO:0042803; GO:0008270 Itself "3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; Golgi apparatus; NADPH binding; [acyl-carrier-protein] S-acetyltransferase activity; [acyl-carrier-protein] S-malonyltransferase activity; acetyl-CoA metabolic process; cellular response to interleukin-4; drug binding; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; fatty acid biosynthetic process; fatty acid synthase activity; glycogen granule; melanosome; mitochondrion; myristoyl-[acyl-carrier-protein] hydrolase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; plasma membrane; protein homodimerization activity; zinc ion binding" IPR001227; IPR009081; IPR014043; IPR016035; IPR013149; IPR023102; IPR011032; IPR018201; IPR014031; IPR014030; IPR016036; IPR013217; IPR016040; IPR020842; IPR020843; IPR013968; IPR006162; IPR001031; IPR016039; IPR016038; Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] Fasn Rattus norvegicus (Rat) TR43043_c0_g4_i2 P12785 FAS_RAT 0 GO:0047451; GO:0004317; GO:0004316; GO:0004315; GO:0005794; GO:0070402; GO:0004313; GO:0004314; GO:0006084; GO:0071353; GO:0008144; GO:0047117; GO:0004319; GO:0006633; GO:0004312; GO:0042587; GO:0042470; GO:0005739; GO:0016295; GO:0004320; GO:0016296; GO:0005886; GO:0042803; GO:0008270 Itself "3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; Golgi apparatus; NADPH binding; [acyl-carrier-protein] S-acetyltransferase activity; [acyl-carrier-protein] S-malonyltransferase activity; acetyl-CoA metabolic process; cellular response to interleukin-4; drug binding; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; fatty acid biosynthetic process; fatty acid synthase activity; glycogen granule; melanosome; mitochondrion; myristoyl-[acyl-carrier-protein] hydrolase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; plasma membrane; protein homodimerization activity; zinc ion binding" IPR001227; IPR009081; IPR014043; IPR016035; IPR013149; IPR023102; IPR011032; IPR018201; IPR014031; IPR014030; IPR016036; IPR013217; IPR016040; IPR020842; IPR020843; IPR013968; IPR006162; IPR001031; IPR016039; IPR016038; Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] Fasn Rattus norvegicus (Rat) TR43044_c0_g2_i1 Q6P616 RBM22_XENTR 0 GO:0005737; GO:0045292; GO:0046872; GO:0007275; GO:0000166; GO:0005634; GO:0033120; GO:0036002; GO:0017069; GO:0005681 "cytoplasm; mRNA cis splicing, via spliceosome; metal ion binding; multicellular organismal development; nucleotide binding; nucleus; positive regulation of RNA splicing; pre-mRNA binding; snRNA binding; spliceosomal complex" IPR012677; IPR000504; IPR000571; Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) rbm22 TEgg040d02.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR43044_c0_g2_i2 Q9SAB3 RB45B_ARATH 3.00E-08 GO:0006397; GO:0000166; GO:0005634; GO:0008143; GO:0010193 mRNA processing; nucleotide binding; nucleus; poly(A) RNA binding; response to ozone IPR012677; IPR000504; Polyadenylate-binding protein RBP45B (Poly(A)-binding protein RBP45B) (RNA-binding protein 45B) (AtRBP45B) RBP45B At1g11650 F25C20.21 Arabidopsis thaliana (Mouse-ear cress) TR43045_c1_g2_i4 O60070 ASH2_SCHPO 2.00E-07 GO:0048189; GO:0048188; GO:0006338; GO:0051568; GO:0000790; GO:0019787; GO:0008270 Lid2 complex; Set1C/COMPASS complex; chromatin remodeling; histone H3-K4 methylation; nuclear chromatin; small conjugating protein ligase activity; zinc ion binding IPR001870; IPR008985; IPR018355; IPR003877; IPR019786; IPR011011; IPR001965; IPR013083; Set1 complex component ash2 (Set1C component ash2) (COMPASS component ash2) (Complex proteins associated with set1 protein ash2) (Lid2 complex component ash2) (Lid2C component ash2) ash2 SPBC13G1.08c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR43045_c1_g2_i5 Q9UBL3 ASH2L_HUMAN 6.00E-41 GO:0071339; GO:0048188; GO:0030097; GO:0051568; GO:0046872; GO:0008284; GO:0045944; GO:0006355; GO:0006974; GO:0043627; GO:0006366; GO:0044212 Q9HCK8; Q9C005; P51610; Q15291 "MLL1 complex; Set1C/COMPASS complex; hemopoiesis; histone H3-K4 methylation; metal ion binding; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to DNA damage stimulus; response to estrogen stimulus; transcription from RNA polymerase II promoter; transcription regulatory region DNA binding" IPR001870; IPR008985; IPR018355; IPR003877; Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) ASH2L ASH2L1 Homo sapiens (Human) TR43046_c0_g1_i1 Q66403 DPOL_DHBVQ 5.00E-06 GO:0003677; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0046872; GO:0090305; GO:0004523 DNA binding; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; ribonuclease H activity IPR001462; IPR000201; IPR000477; Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4)] P Duck hepatitis B virus (isolate Shanghai/DHBVQCA34) (DHBV) TR43046_c0_g1_i2 O50655 XERD_SELRU 9.00E-09 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR43046_c0_g1_i4 O50655 XERD_SELRU 9.00E-09 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR43049_c2_g4_i1 G5EGD2 HIF1_CAEEL 4.00E-20 GO:0003677; GO:0006915; GO:0061433; GO:0008340; GO:0010286; GO:0043066; GO:0005634; GO:0000160; GO:0001666; GO:0003700; GO:0004871; GO:0006366 O02219 DNA binding; apoptotic process; cellular response to caloric restriction; determination of adult lifespan; heat acclimation; negative regulation of apoptotic process; nucleus; phosphorelay signal transduction system; response to hypoxia; sequence-specific DNA binding transcription factor activity; signal transducer activity; transcription from RNA polymerase II promoter IPR011598; IPR001610; IPR000014; IPR013767; Hypoxia-inducible factor 1 (Hypoxia-induced factor 1) hif-1 F38A6.3 Caenorhabditis elegans TR43049_c2_g5_i1 Q9XTA5 HIF1A_BOVIN 6.00E-65 GO:0019896; GO:0071456; GO:0005737; GO:0035035; GO:0005634; GO:0045893; GO:0003700; GO:0004871; GO:0044212; GO:0006351 "axon transport of mitochondrion; cellular response to hypoxia; cytoplasm; histone acetyltransferase binding; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; signal transducer activity; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR011598; IPR001321; IPR014887; IPR021537; IPR001610; IPR000014; IPR013767; Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) HIF1A Bos taurus (Bovine) TR43049_c2_g5_i2 Q98SW2 HIF1A_ONCMY 4.00E-65 GO:0003677; GO:0005737; GO:0005634; GO:0006355; GO:0004871; GO:0006351 "DNA binding; cytoplasm; nucleus; regulation of transcription, DNA-dependent; signal transducer activity; transcription, DNA-dependent" IPR011598; IPR014887; IPR021537; IPR001610; IPR000014; Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) hif1a Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) TR43055_c1_g2_i1 Q62371 DDR2_MOUSE 6.00E-127 GO:0005524; GO:0031214; GO:0007155; GO:0035988; GO:0005518; GO:0030199; GO:0003416; GO:0016021; GO:0001503; GO:0005886; GO:0090091; GO:0010763; GO:0048146; GO:0045669; GO:0045860; GO:0051091; GO:0046777; GO:0038062; GO:0030500 ATP binding; biomineral tissue development; cell adhesion; chondrocyte proliferation; collagen binding; collagen fibril organization; endochondral bone growth; integral to membrane; ossification; plasma membrane; positive regulation of extracellular matrix disassembly; positive regulation of fibroblast migration; positive regulation of fibroblast proliferation; positive regulation of osteoblast differentiation; positive regulation of protein kinase activity; positive regulation of sequence-specific DNA binding transcription factor activity; protein autophosphorylation; protein tyrosine kinase collagen receptor activity; regulation of bone mineralization IPR000421; IPR008979; IPR011009; IPR000719; IPR001245; IPR008266; IPR020635; IPR002011; "Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)" Ddr2 Ntrkr3 Tkt Tyro10 Mus musculus (Mouse) TR43055_c1_g2_i3 Q08345 DDR1_HUMAN 2.00E-116 GO:0005524; GO:0060444; GO:0005518; GO:0043583; GO:0007566; GO:0030198; GO:0005576; GO:0005887; GO:0007595; GO:0060749; GO:0046872; GO:0008285; GO:0038083; GO:0038062; GO:0001558; GO:0001952; GO:0010715; GO:0014909; GO:0061302; GO:0044319 O43639; Q06124 "ATP binding; branching involved in mammary gland duct morphogenesis; collagen binding; ear development; embryo implantation; extracellular matrix organization; extracellular region; integral to plasma membrane; lactation; mammary gland alveolus development; metal ion binding; negative regulation of cell proliferation; peptidyl-tyrosine autophosphorylation; protein tyrosine kinase collagen receptor activity; regulation of cell growth; regulation of cell-matrix adhesion; regulation of extracellular matrix disassembly; smooth muscle cell migration; smooth muscle cell-matrix adhesion; wound healing, spreading of cells" IPR000421; IPR008979; IPR011009; IPR000719; IPR001245; IPR008266; IPR020635; IPR002011; Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a) DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE Homo sapiens (Human) TR43055_c1_g2_i4 P00451 FA8_HUMAN 5.00E-12 GO:0006953; GO:0007597; GO:0007155; GO:0005507; GO:0005576; GO:0005615; GO:0016491; GO:0005886; GO:0030168; GO:0031093; GO:0002576 "acute-phase response; blood coagulation, intrinsic pathway; cell adhesion; copper ion binding; extracellular region; extracellular space; oxidoreductase activity; plasma membrane; platelet activation; platelet alpha granule lumen; platelet degranulation" IPR000421; IPR001117; IPR011706; IPR011707; IPR002355; IPR008972; IPR024715; IPR008979; "Coagulation factor VIII (Antihemophilic factor) (AHF) (Procoagulant component) [Cleaved into: Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain]" F8 F8C Homo sapiens (Human) TR43055_c1_g2_i5 Q62371 DDR2_MOUSE 3.00E-128 GO:0005524; GO:0031214; GO:0007155; GO:0035988; GO:0005518; GO:0030199; GO:0003416; GO:0016021; GO:0001503; GO:0005886; GO:0090091; GO:0010763; GO:0048146; GO:0045669; GO:0045860; GO:0051091; GO:0046777; GO:0038062; GO:0030500 ATP binding; biomineral tissue development; cell adhesion; chondrocyte proliferation; collagen binding; collagen fibril organization; endochondral bone growth; integral to membrane; ossification; plasma membrane; positive regulation of extracellular matrix disassembly; positive regulation of fibroblast migration; positive regulation of fibroblast proliferation; positive regulation of osteoblast differentiation; positive regulation of protein kinase activity; positive regulation of sequence-specific DNA binding transcription factor activity; protein autophosphorylation; protein tyrosine kinase collagen receptor activity; regulation of bone mineralization IPR000421; IPR008979; IPR011009; IPR000719; IPR001245; IPR008266; IPR020635; IPR002011; "Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)" Ddr2 Ntrkr3 Tkt Tyro10 Mus musculus (Mouse) TR43055_c1_g2_i6 Q62371 DDR2_MOUSE 2.00E-129 GO:0005524; GO:0031214; GO:0007155; GO:0035988; GO:0005518; GO:0030199; GO:0003416; GO:0016021; GO:0001503; GO:0005886; GO:0090091; GO:0010763; GO:0048146; GO:0045669; GO:0045860; GO:0051091; GO:0046777; GO:0038062; GO:0030500 ATP binding; biomineral tissue development; cell adhesion; chondrocyte proliferation; collagen binding; collagen fibril organization; endochondral bone growth; integral to membrane; ossification; plasma membrane; positive regulation of extracellular matrix disassembly; positive regulation of fibroblast migration; positive regulation of fibroblast proliferation; positive regulation of osteoblast differentiation; positive regulation of protein kinase activity; positive regulation of sequence-specific DNA binding transcription factor activity; protein autophosphorylation; protein tyrosine kinase collagen receptor activity; regulation of bone mineralization IPR000421; IPR008979; IPR011009; IPR000719; IPR001245; IPR008266; IPR020635; IPR002011; "Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)" Ddr2 Ntrkr3 Tkt Tyro10 Mus musculus (Mouse) TR43056_c1_g2_i1 Q5R5U1 RAB10_PONAB 1.00E-106 GO:0019003; GO:0005525; GO:0003924; GO:0005794; GO:0043001; GO:0007409; GO:0061467; GO:0032869; GO:0005789; GO:0071782; GO:0071786; GO:0016197; GO:0045200; GO:0097051; GO:0032593; GO:0030670; GO:0005886; GO:0030859; GO:0072372; GO:0055037; GO:0055038; GO:0007264; GO:0005802 GDP binding; GTP binding; GTPase activity; Golgi apparatus; Golgi to plasma membrane protein transport; axonogenesis; basolateral protein localization; cellular response to insulin stimulus; endoplasmic reticulum membrane; endoplasmic reticulum tubular network; endoplasmic reticulum tubular network organization; endosomal transport; establishment of neuroblast polarity; establishment of protein localization to endoplasmic reticulum membrane; insulin-responsive compartment; phagocytic vesicle membrane; plasma membrane; polarized epithelial cell differentiation; primary cilium; recycling endosome; recycling endosome membrane; small GTPase mediated signal transduction; trans-Golgi network IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-10 RAB10 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR43056_c1_g2_i3 P22127 RAB10_DISOM 6.00E-102 GO:0019003; GO:0005525; GO:0005794; GO:0043001; GO:0007409; GO:0061467; GO:0032869; GO:0005789; GO:0071782; GO:0071786; GO:0016197; GO:0045200; GO:0097051; GO:0032593; GO:0030670; GO:0030859; GO:0072372; GO:0055037; GO:0055038; GO:0007264; GO:0005802 GDP binding; GTP binding; Golgi apparatus; Golgi to plasma membrane protein transport; axonogenesis; basolateral protein localization; cellular response to insulin stimulus; endoplasmic reticulum membrane; endoplasmic reticulum tubular network; endoplasmic reticulum tubular network organization; endosomal transport; establishment of neuroblast polarity; establishment of protein localization to endoplasmic reticulum membrane; insulin-responsive compartment; phagocytic vesicle membrane; polarized epithelial cell differentiation; primary cilium; recycling endosome; recycling endosome membrane; small GTPase mediated signal transduction; trans-Golgi network IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-10 (ORA1) Diplobatis ommata (Ocellated electric ray) (Discopyge ommata) TR43057_c0_g2_i1 Q9Y376 CAB39_HUMAN 4.00E-162 GO:0007050; GO:0005829; GO:0008286; GO:0030295 Q9P289; O95747; Q15831; O00506; Q9UEW8; Q7RTN6; Q9C0K7 cell cycle arrest; cytosol; insulin receptor signaling pathway; protein kinase activator activity IPR011989; IPR016024; IPR013878; Calcium-binding protein 39 (MO25alpha) (Protein Mo25) CAB39 MO25 CGI-66 Homo sapiens (Human) TR43059_c0_g1_i1 O61491 FLOT1_DROME 2.00E-71 GO:0016600; GO:0007275; GO:0005198 flotillin complex; multicellular organismal development; structural molecule activity IPR001107; IPR027705; Flotillin-1 Flo FLODM-1 CG8200 Drosophila melanogaster (Fruit fly) TR43059_c0_g1_i2 O61492 FLOT2_DROME 5.00E-142 GO:0007155; GO:0016600; GO:0035011; GO:0005198 cell adhesion; flotillin complex; melanotic encapsulation of foreign target; structural molecule activity IPR001107; IPR027705; Flotillin-2 Flo-2 FLODm-2 CG32593 Drosophila melanogaster (Fruit fly) TR4306_c0_g1_i1 Q9ULK2 AT7L1_HUMAN 2.00E-07 IPR013243; Ataxin-7-like protein 1 (Ataxin-7-like protein 4) ATXN7L1 ATXN7L4 KIAA1218 Homo sapiens (Human) TR43060_c1_g1_i1 Q8NBI5 S43A3_HUMAN 1.00E-39 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR016196; IPR027192; IPR027197; Solute carrier family 43 member 3 (Protein FOAP-13) SLC43A3 PSEC0252 Homo sapiens (Human) TR43062_c1_g1_i1 Q8R151 ZNFX1_MOUSE 0 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR43062_c1_g1_i2 O74465 HRR1_SCHPO 2.00E-50 GO:0005524; GO:0003723; GO:0007049; GO:0006338; GO:0030702; GO:0031048; GO:0007059; GO:0005829; GO:0004386; GO:0031380 ATP binding; RNA binding; cell cycle; chromatin remodeling; chromatin silencing at centromere; chromatin silencing by small RNA; chromosome segregation; cytosol; helicase activity; nuclear RNA-directed RNA polymerase complex IPR027417; Helicase required for RNAi-mediated heterochromatin assembly 1 (EC 3.6.4.13) hrr1 SPCC1739.03 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR43062_c1_g1_i3 Q9P2E3 ZNFX1_HUMAN 3.00E-180 GO:0046872 metal ion binding IPR016024; IPR027417; NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) TR43063_c5_g2_i1 Q43472 GRP_HORVU 3.00E-12 GO:0003723; GO:0006397; GO:0000166; GO:0009737; GO:0009409; GO:0003697; GO:0006351 "RNA binding; mRNA processing; nucleotide binding; response to abscisic acid stimulus; response to cold; single-stranded DNA binding; transcription, DNA-dependent" IPR012677; IPR000504; Glycine-rich RNA-binding protein blt801 (Low temperature-responsive RNA-binding protein) blt801 Hordeum vulgare (Barley) TR43063_c5_g2_i2 P11940 PABP1_HUMAN 0 GO:0071013; GO:0010494; GO:0005829; GO:0031047; GO:0006378; GO:0000398; GO:0048255; GO:2000623; GO:0000184; GO:0000289; GO:0000166; GO:0008143; GO:1900153; GO:0060213; GO:0008494; GO:0006413 Q99700; O00571; Q04637; Q8IYD1; Q14103-4; P35568; Q9H074; Q96Q15; Q9UPQ9; Q9HCJ0; Q14106 "catalytic step 2 spliceosome; cytoplasmic stress granule; cytosol; gene silencing by RNA; mRNA polyadenylation; mRNA splicing, via spliceosome; mRNA stabilization; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nuclear-transcribed mRNA poly(A) tail shortening; nucleotide binding; poly(A) RNA binding; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; translation activator activity; translational initiation" IPR012677; IPR006515; IPR002004; IPR000504; Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) PABPC1 PAB1 PABP1 PABPC2 Homo sapiens (Human) TR43064_c0_g1_i1 Q62077 PLCG1_MOUSE 0 GO:0050852; GO:0005509; GO:0071364; GO:0005829; GO:0001701; GO:0035556; GO:0030027; GO:0004435; GO:0005543; GO:0009395; GO:0010634; GO:0001726; GO:0004871 P14753; Q60631; O54957; P48356 T cell receptor signaling pathway; calcium ion binding; cellular response to epidermal growth factor stimulus; cytosol; in utero embryonic development; intracellular signal transduction; lamellipodium; phosphatidylinositol phospholipase C activity; phospholipid binding; phospholipid catabolic process; positive regulation of epithelial cell migration; ruffle; signal transducer activity IPR000008; IPR011992; IPR018247; IPR002048; IPR011993; IPR001192; IPR016279; IPR017946; IPR001849; IPR015359; IPR000909; IPR001711; IPR000980; IPR001452; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-gamma-1) (PLC-gamma-1)" Plcg1 Plcg-1 Mus musculus (Mouse) TR43064_c0_g1_i2 O75038 PLCH2_HUMAN 4.00E-57 GO:0005509; GO:0005737; GO:0043647; GO:0035556; GO:0016042; GO:0046488; GO:0004435; GO:0005543; GO:0005886; GO:0004871 calcium ion binding; cytoplasm; inositol phosphate metabolic process; intracellular signal transduction; lipid catabolic process; phosphatidylinositol metabolic process; phosphatidylinositol phospholipase C activity; phospholipid binding; plasma membrane; signal transducer activity IPR000008; IPR011992; IPR018247; IPR002048; IPR011993; IPR001192; IPR017946; IPR001849; IPR015359; IPR000909; IPR001711; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-2) (Phosphoinositide phospholipase C-like 4) (PLC-L4) (Phospholipase C-like protein 4) (Phospholipase C-eta-2) (PLC-eta2)" PLCH2 KIAA0450 PLCL4 Homo sapiens (Human) TR43064_c0_g1_i3 P29349 CSW_DROME 3.00E-15 GO:0005737; GO:0008069; GO:0007173; GO:0007427; GO:0008543; GO:0007444; GO:0007498; GO:0000278; GO:0043066; GO:0004726; GO:0007428; GO:0004728; GO:0045314; GO:0045500; GO:0007362; GO:0008293; GO:0007418 "cytoplasm; dorsal/ventral axis specification, ovarian follicular epithelium; epidermal growth factor receptor signaling pathway; epithelial cell migration, open tracheal system; fibroblast growth factor receptor signaling pathway; imaginal disc development; mesoderm development; mitotic cell cycle; negative regulation of apoptotic process; non-membrane spanning protein tyrosine phosphatase activity; primary branching, open tracheal system; receptor signaling protein tyrosine phosphatase activity; regulation of compound eye photoreceptor development; sevenless signaling pathway; terminal region determination; torso signaling pathway; ventral midline development" IPR000980; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase corkscrew (EC 3.1.3.48) csw CG3954 Drosophila melanogaster (Fruit fly) TR43064_c0_g1_i4 Q62077 PLCG1_MOUSE 0 GO:0050852; GO:0005509; GO:0071364; GO:0005829; GO:0001701; GO:0035556; GO:0030027; GO:0004435; GO:0005543; GO:0009395; GO:0010634; GO:0001726; GO:0004871 P14753; Q60631; O54957; P48356 T cell receptor signaling pathway; calcium ion binding; cellular response to epidermal growth factor stimulus; cytosol; in utero embryonic development; intracellular signal transduction; lamellipodium; phosphatidylinositol phospholipase C activity; phospholipid binding; phospholipid catabolic process; positive regulation of epithelial cell migration; ruffle; signal transducer activity IPR000008; IPR011992; IPR018247; IPR002048; IPR011993; IPR001192; IPR016279; IPR017946; IPR001849; IPR015359; IPR000909; IPR001711; IPR000980; IPR001452; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-gamma-1) (PLC-gamma-1)" Plcg1 Plcg-1 Mus musculus (Mouse) TR43064_c0_g1_i5 Q4KWH8 PLCH1_HUMAN 2.00E-57 GO:0005509; GO:0050429; GO:0005737; GO:0005829; GO:0043647; GO:0016042; GO:0031965; GO:0004435; GO:0048015; GO:0005543; GO:0005886; GO:0004871 calcium ion binding; calcium-dependent phospholipase C activity; cytoplasm; cytosol; inositol phosphate metabolic process; lipid catabolic process; nuclear membrane; phosphatidylinositol phospholipase C activity; phosphatidylinositol-mediated signaling; phospholipid binding; plasma membrane; signal transducer activity IPR000008; IPR011992; IPR018247; IPR002048; IPR011993; IPR001192; IPR017946; IPR001849; IPR015359; IPR000909; IPR001711; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3)" PLCH1 KIAA1069 PLCL3 Homo sapiens (Human) TR43064_c0_g1_i6 A2AP18 PLCH2_MOUSE 1.00E-58 GO:0005509; GO:0005737; GO:0035556; GO:0016042; GO:0046488; GO:0004435; GO:0004629; GO:0005543; GO:0005886; GO:0004871 calcium ion binding; cytoplasm; intracellular signal transduction; lipid catabolic process; phosphatidylinositol metabolic process; phosphatidylinositol phospholipase C activity; phospholipase C activity; phospholipid binding; plasma membrane; signal transducer activity IPR000008; IPR011992; IPR018247; IPR002048; IPR011993; IPR001192; IPR017946; IPR001849; IPR015359; IPR000909; IPR001711; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-2) (Phosphoinositide phospholipase C-like 4) (PLC-L4) (Phospholipase C-like protein 4) (Phospholipase C-eta-2) (PLC-eta2)" Plch2 Plcl4 Mus musculus (Mouse) TR43064_c0_g1_i7 Q62077 PLCG1_MOUSE 0 GO:0050852; GO:0005509; GO:0071364; GO:0005829; GO:0001701; GO:0035556; GO:0030027; GO:0004435; GO:0005543; GO:0009395; GO:0010634; GO:0001726; GO:0004871 P14753; Q60631; O54957; P48356 T cell receptor signaling pathway; calcium ion binding; cellular response to epidermal growth factor stimulus; cytosol; in utero embryonic development; intracellular signal transduction; lamellipodium; phosphatidylinositol phospholipase C activity; phospholipid binding; phospholipid catabolic process; positive regulation of epithelial cell migration; ruffle; signal transducer activity IPR000008; IPR011992; IPR018247; IPR002048; IPR011993; IPR001192; IPR016279; IPR017946; IPR001849; IPR015359; IPR000909; IPR001711; IPR000980; IPR001452; "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-gamma-1) (PLC-gamma-1)" Plcg1 Plcg-1 Mus musculus (Mouse) TR43066_c2_g2_i1 P08183 MDR1_HUMAN 0 GO:0005524; GO:0042626; GO:0000086; GO:0000139; GO:0016324; GO:0009986; GO:0006855; GO:0016021; GO:0046581; GO:0072089; GO:0008559 Q86VI4; Q99496 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; G2/M transition of mitotic cell cycle; Golgi membrane; apical plasma membrane; cell surface; drug transmembrane transport; integral to membrane; intercellular canaliculus; stem cell proliferation; xenobiotic-transporting ATPase activity" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD antigen CD243) ABCB1 MDR1 PGY1 Homo sapiens (Human) TR43066_c2_g2_i3 P08183 MDR1_HUMAN 0 GO:0005524; GO:0042626; GO:0000086; GO:0000139; GO:0016324; GO:0009986; GO:0006855; GO:0016021; GO:0046581; GO:0072089; GO:0008559 Q86VI4; Q99496 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; G2/M transition of mitotic cell cycle; Golgi membrane; apical plasma membrane; cell surface; drug transmembrane transport; integral to membrane; intercellular canaliculus; stem cell proliferation; xenobiotic-transporting ATPase activity" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD antigen CD243) ABCB1 MDR1 PGY1 Homo sapiens (Human) TR43066_c2_g2_i4 Q9ZR72 AB1B_ARATH 2.00E-150 GO:0005524; GO:0042626; GO:0010541; GO:0043481; GO:0010329; GO:0010328; GO:0010540; GO:0016021; GO:0009640; GO:0005886; GO:0009506; GO:0009958; GO:0008361; GO:0009637; GO:0009624; GO:0048443 Q9LDC0 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; acropetal auxin transport; anthocyanin accumulation in tissues in response to UV light; auxin efflux transmembrane transporter activity; auxin influx transmembrane transporter activity; basipetal auxin transport; integral to membrane; photomorphogenesis; plasma membrane; plasmodesma; positive gravitropism; regulation of cell size; response to blue light; response to nematode; stamen development" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; ABC transporter B family member 1 (ABC transporter ABCB.1) (AtABCB1) (Multidrug resistance protein 1) (P-glycoprotein 1) (AtPgp1) ABCB1 MDR1 PGP1 At2g36910 T1J8.9 Arabidopsis thaliana (Mouse-ear cress) TR43066_c2_g2_i5 Q9QY30 ABCBB_MOUSE 0 GO:0005524; GO:0042626; GO:0000139; GO:0016324; GO:0015126; GO:0016021; GO:0046581 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; Golgi membrane; apical plasma membrane; canalicular bile acid transmembrane transporter activity; integral to membrane; intercellular canaliculus" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Bile salt export pump (ATP-binding cassette sub-family B member 11) (Sister of P-glycoprotein) Abcb11 Bsep Spgp Mus musculus (Mouse) TR43066_c2_g2_i8 Q9FWX8 AB12B_ARATH 3.00E-145 GO:0005524; GO:0006200; GO:0042626; GO:0016021 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; ABC transporter B family member 12 (ABC transporter ABCB.12) (AtABCB12) (Multidrug resistance protein 16) (P-glycoprotein 12) ABCB12 MDR16 PGP12 At1g02530 T14P4.14 Arabidopsis thaliana (Mouse-ear cress) TR43066_c2_g2_i9 P08183 MDR1_HUMAN 0 GO:0005524; GO:0042626; GO:0000086; GO:0000139; GO:0016324; GO:0009986; GO:0006855; GO:0016021; GO:0046581; GO:0072089; GO:0008559 Q86VI4; Q99496 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; G2/M transition of mitotic cell cycle; Golgi membrane; apical plasma membrane; cell surface; drug transmembrane transport; integral to membrane; intercellular canaliculus; stem cell proliferation; xenobiotic-transporting ATPase activity" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR027417; Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD antigen CD243) ABCB1 MDR1 PGY1 Homo sapiens (Human) TR43066_c2_g3_i1 Q13KX9 TAUB2_BURXL 7.00E-10 GO:0005524; GO:0006200; GO:0005886; GO:0015734; GO:0015411 ATP binding; ATP catabolic process; plasma membrane; taurine transport; taurine-transporting ATPase activity IPR003593; IPR003439; IPR017871; IPR015859; IPR027417; Taurine import ATP-binding protein TauB 2 (EC 3.6.3.36) tauB2 Bxeno_B2292 Bxe_B0693 Burkholderia xenovorans (strain LB400) TR43066_c2_g3_i2 Q8YM92 POTA_NOSS1 6.00E-21 GO:0005524; GO:0006200; GO:0043190; GO:0005886; GO:0015594; GO:0015595 ATP binding; ATP catabolic process; ATP-binding cassette (ABC) transporter complex; plasma membrane; putrescine-importing ATPase activity; spermidine-importing ATPase activity IPR003593; IPR017879; IPR003439; IPR017871; IPR008995; IPR027417; IPR005893; IPR013611; Spermidine/putrescine import ATP-binding protein PotA (EC 3.6.3.31) potA all5044 Nostoc sp. (strain PCC 7120 / UTEX 2576) TR43066_c2_g3_i3 Q28Q03 PSTB_JANSC 6.00E-23 GO:0005524; GO:0006200; GO:0005315; GO:0015415; GO:0005886 ATP binding; ATP catabolic process; inorganic phosphate transmembrane transporter activity; phosphate ion transmembrane-transporting ATPase activity; plasma membrane IPR003593; IPR003439; IPR017871; IPR015850; IPR027417; IPR005670; Phosphate import ATP-binding protein PstB (EC 3.6.3.27) (ABC phosphate transporter) (Phosphate-transporting ATPase) pstB Jann_2292 Jannaschia sp. (strain CCS1) TR43066_c2_g3_i4 Q2W8B4 PSTB1_MAGSA 2.00E-28 GO:0005524; GO:0006200; GO:0005315; GO:0015415; GO:0005886 ATP binding; ATP catabolic process; inorganic phosphate transmembrane transporter activity; phosphate ion transmembrane-transporting ATPase activity; plasma membrane IPR003593; IPR003439; IPR017871; IPR015850; IPR027417; IPR005670; Phosphate import ATP-binding protein PstB 1 (EC 3.6.3.27) (ABC phosphate transporter 1) (Phosphate-transporting ATPase 1) pstB1 amb1107 Magnetospirillum magneticum (strain AMB-1 / ATCC 700264) TR43066_c2_g3_i5 O88563 MRP3_RAT 4.00E-34 GO:0005524; GO:0016323; GO:0015432; GO:0015722; GO:0016021; GO:0032355; GO:0032496; GO:0010243; GO:0008559 ATP binding; basolateral plasma membrane; bile acid-exporting ATPase activity; canalicular bile acid transport; integral to membrane; response to estradiol stimulus; response to lipopolysaccharide; response to organonitrogen compound; xenobiotic-transporting ATPase activity IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (MRP-like protein 2) (MLP-2) (Multidrug resistance-associated protein 3) Abcc3 Cmoat2 Mlp2 Mrp3 Rattus norvegicus (Rat) TR43067_c1_g1_i2 O60500 NPHN_HUMAN 4.00E-50 GO:0007254; GO:0007155; GO:0042995; GO:0007588; GO:0032836; GO:0072015; GO:0005887; GO:0007520; GO:0030838; GO:0044062; GO:0007519; GO:0036057 P46940; P16333 JNK cascade; cell adhesion; cell projection; excretion; glomerular basement membrane development; glomerular visceral epithelial cell development; integral to plasma membrane; myoblast fusion; positive regulation of actin filament polymerization; regulation of excretion; skeletal muscle tissue development; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) NPHS1 NPHN Homo sapiens (Human) TR43067_c1_g2_i1 O60500 NPHN_HUMAN 6.00E-10 GO:0007254; GO:0007155; GO:0042995; GO:0007588; GO:0032836; GO:0072015; GO:0005887; GO:0007520; GO:0030838; GO:0044062; GO:0007519; GO:0036057 P46940; P16333 JNK cascade; cell adhesion; cell projection; excretion; glomerular basement membrane development; glomerular visceral epithelial cell development; integral to plasma membrane; myoblast fusion; positive regulation of actin filament polymerization; regulation of excretion; skeletal muscle tissue development; slit diaphragm IPR013162; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; Nephrin (Renal glomerulus-specific cell adhesion receptor) NPHS1 NPHN Homo sapiens (Human) TR43068_c2_g1_i1 Q91WG5 AAKG2_MOUSE 1.00E-133 GO:0043531; GO:0004679; GO:0031588; GO:0005524; GO:0004862; GO:0008603; GO:0005829; GO:0006633; GO:0005977; GO:0007243; GO:0008607; GO:0010800; GO:0030295; GO:0019217; GO:0006110 ADP binding; AMP-activated protein kinase activity; AMP-activated protein kinase complex; ATP binding; cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; cytosol; fatty acid biosynthetic process; glycogen metabolic process; intracellular protein kinase cascade; phosphorylase kinase regulator activity; positive regulation of peptidyl-threonine phosphorylation; protein kinase activator activity; regulation of fatty acid metabolic process; regulation of glycolysis IPR000644; 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) Prkag2 Mus musculus (Mouse) TR43068_c2_g1_i3 Q9UGI9 AAKG3_HUMAN 1.00E-115 GO:0004679; GO:0031588; GO:0005524; GO:0007050; GO:0005829; GO:0006633; GO:0015758; GO:0005978; GO:0008286; GO:0007243; GO:0019901 AMP-activated protein kinase activity; AMP-activated protein kinase complex; ATP binding; cell cycle arrest; cytosol; fatty acid biosynthetic process; glucose transport; glycogen biosynthetic process; insulin receptor signaling pathway; intracellular protein kinase cascade; protein kinase binding IPR000644; 5'-AMP-activated protein kinase subunit gamma-3 (AMPK gamma3) (AMPK subunit gamma-3) PRKAG3 AMPKG3 Homo sapiens (Human) TR43068_c2_g1_i6 Q91WG5 AAKG2_MOUSE 4.00E-138 GO:0043531; GO:0004679; GO:0031588; GO:0005524; GO:0004862; GO:0008603; GO:0005829; GO:0006633; GO:0005977; GO:0007243; GO:0008607; GO:0010800; GO:0030295; GO:0019217; GO:0006110 ADP binding; AMP-activated protein kinase activity; AMP-activated protein kinase complex; ATP binding; cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; cytosol; fatty acid biosynthetic process; glycogen metabolic process; intracellular protein kinase cascade; phosphorylase kinase regulator activity; positive regulation of peptidyl-threonine phosphorylation; protein kinase activator activity; regulation of fatty acid metabolic process; regulation of glycolysis IPR000644; 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) Prkag2 Mus musculus (Mouse) TR43069_c1_g1_i1 P12264 41_CHICK 4.00E-14 GO:0005545; GO:0005794; GO:0030863; GO:0005634; GO:0005886; GO:0032092; GO:0043234 1-phosphatidylinositol binding; Golgi apparatus; cortical cytoskeleton; nucleus; plasma membrane; positive regulation of protein binding; protein complex IPR000299; IPR018980; IPR011993; Erythroid protein 4.1 (Band 4.1) (Fragment) EPB41 Gallus gallus (Chicken) TR43069_c1_g4_i2 Q12923 PTN13_HUMAN 6.00E-07 GO:0005737; GO:0005856; GO:0030027; GO:0005634; GO:0005886; GO:0004725 P25445; Q9BUL8; Q8TEU7 cytoplasm; cytoskeleton; lamellipodium; nucleus; plasma membrane; protein tyrosine phosphatase activity IPR019749; IPR019750; IPR014352; IPR019748; IPR000299; IPR018979; IPR018980; IPR011019; IPR001478; IPR011993; IPR000387; IPR012153; IPR000242; Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) PTPN13 PNP1 PTP1E PTPL1 Homo sapiens (Human) TR43069_c1_g4_i3 A2AD83 FRMD7_MOUSE 1.00E-61 GO:0005856; GO:0030426; GO:0043025; GO:0010975 cytoskeleton; growth cone; neuronal cell body; regulation of neuron projection development IPR019749; IPR019750; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; FERM domain-containing protein 7 Frmd7 Mus musculus (Mouse) TR43069_c1_g5_i1 Q91VS8 FARP2_MOUSE 2.00E-166 GO:0030676; GO:0016601; GO:0031532; GO:0007155; GO:0005856; GO:0005829; GO:0019898; GO:0016322; GO:0030316; GO:0005543; GO:0071800; GO:0035023; GO:0033623; GO:0071526 Rac guanyl-nucleotide exchange factor activity; Rac protein signal transduction; actin cytoskeleton reorganization; cell adhesion; cytoskeleton; cytosol; extrinsic to membrane; neuron remodeling; osteoclast differentiation; phospholipid binding; podosome assembly; regulation of Rho protein signal transduction; regulation of integrin activation; semaphorin-plexin signaling pathway IPR019749; IPR019750; IPR000219; IPR000798; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; IPR001849; "FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR)" Farp2 Kiaa0793 Mus musculus (Mouse) TR43070_c2_g2_i1 Q9VF87 CYFIP_DROME 0 GO:0031209; GO:0045177; GO:0007411; GO:0030031; GO:0022416; GO:0001745; GO:0030866; GO:0006909; GO:0008360; GO:0050807 Q24150 SCAR complex; apical part of cell; axon guidance; cell projection assembly; chaeta development; compound eye morphogenesis; cortical actin cytoskeleton organization; phagocytosis; regulation of cell shape; regulation of synapse organization IPR008081; IPR016536; IPR009828; Cytoplasmic FMR1-interacting protein (Specifically Rac1-associated protein 1) (DSra-1) Sra-1 Cyfip CG4931 Drosophila melanogaster (Fruit fly) TR43070_c2_g2_i3 Q299G2 CYFIP_DROPS 6.00E-169 GO:0031209; GO:0007411; GO:0030031; GO:0022416; GO:0030866; GO:0008360; GO:0050807 SCAR complex; axon guidance; cell projection assembly; chaeta development; cortical actin cytoskeleton organization; regulation of cell shape; regulation of synapse organization IPR008081; IPR016536; IPR009828; Cytoplasmic FMR1-interacting protein (Specifically Rac1-associated protein 1) Sra-1 GA18534 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR43073_c1_g1_i1 Q9GV77 FREM2_LYTVA 0 GO:0005509; GO:0007154; GO:0007156; GO:0016021; GO:0007275; GO:0005886 calcium ion binding; cell communication; homophilic cell adhesion; integral to membrane; multicellular organismal development; plasma membrane IPR002126; IPR003644; Extracellular matrix protein 3 (FREM2 homolog) ECM3 Lytechinus variegatus (Green sea urchin) (Variegated urchin) TR43074_c0_g2_i4 Q99JZ0 SDCB2_MOUSE 3.00E-95 GO:0005737; GO:0008022; GO:0046982; GO:0042803 cytoplasm; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity IPR001478; Syntenin-2 (Syndecan-binding protein 2) Sdcbp2 Mus musculus (Mouse) TR43074_c0_g2_i6 O08992 SDCB1_MOUSE 7.00E-113 GO:0007265; GO:0070062; GO:0005137; GO:0005895; GO:0042470; GO:0042327 P52795 Ras protein signal transduction; extracellular vesicular exosome; interleukin-5 receptor binding; interleukin-5 receptor complex; melanosome; positive regulation of phosphorylation IPR001478; Syntenin-1 (Scaffold protein Pbp1) (Syndecan-binding protein 1) Sdcbp Mus musculus (Mouse) TR43075_c3_g1_i1 Q8NDA2 HMCN2_HUMAN 1.00E-09 GO:0005509; GO:0005578; GO:0050896 calcium ion binding; proteinaceous extracellular matrix; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 HMCN2 Homo sapiens (Human) TR43075_c3_g4_i2 Q6MG64 VWA7_RAT 3.00E-15 GO:0005576 extracellular region IPR002035; von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 G7c Rattus norvegicus (Rat) TR43076_c0_g1_i1 Q9UHF1 EGFL7_HUMAN 1.00E-11 GO:0001525; GO:0005509; GO:0005576; GO:0005615; GO:0045746; GO:0030336; GO:0001938; GO:0001570 angiogenesis; calcium ion binding; extracellular region; extracellular space; negative regulation of Notch signaling pathway; negative regulation of cell migration; positive regulation of endothelial cell proliferation; vasculogenesis IPR000742; IPR001881; IPR013032; IPR018097; IPR013111; IPR011489; IPR009030; Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1) EGFL7 MEGF7 UNQ187/PRO1449 Homo sapiens (Human) TR43076_c0_g1_i2 Q2PZL6 FAT4_MOUSE 5.00E-11 GO:0045177; GO:0001658; GO:0005509; GO:0048565; GO:0001736; GO:0003007; GO:0007156; GO:0060122; GO:0016021; GO:0001822; GO:0043931; GO:0005886; GO:0007009 apical part of cell; branching involved in ureteric bud morphogenesis; calcium ion binding; digestive tract development; establishment of planar polarity; heart morphogenesis; homophilic cell adhesion; inner ear receptor stereocilium organization; integral to membrane; kidney development; ossification involved in bone maturation; plasma membrane; plasma membrane organization IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) Fat4 Fatj Mus musculus (Mouse) TR43076_c0_g1_i4 Q8N2E2 VWDE_HUMAN 4.00E-10 GO:0005576 extracellular region IPR000742; IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) TR43076_c1_g2_i2 P55245 EGFR_MACMU 5.00E-14 GO:0005524; GO:0000139; GO:0016323; GO:0000902; GO:0008283; GO:0016337; GO:0071392; GO:0021795; GO:0003682; GO:0048546; GO:0001892; GO:0030139; GO:0005789; GO:0005768; GO:0010008; GO:0005006; GO:0001942; GO:0045121; GO:0060571; GO:0043066; GO:0042177; GO:0030235; GO:0031965; GO:0005634; GO:0048471; GO:0045739; GO:0045740; GO:0070374; GO:0043406; GO:0035413; GO:0030335; GO:0031659; GO:0050679; GO:0048146; GO:0045429; GO:0051897; GO:0001934; GO:0045944; GO:0046777; GO:0004713; GO:0050999; GO:0050730; GO:0070141; GO:0007435 ATP binding; Golgi membrane; basolateral plasma membrane; cell morphogenesis; cell proliferation; cell-cell adhesion; cellular response to estradiol stimulus; cerebral cortex cell migration; chromatin binding; digestive tract morphogenesis; embryonic placenta development; endocytic vesicle; endoplasmic reticulum membrane; endosome; endosome membrane; epidermal growth factor-activated receptor activity; hair follicle development; membrane raft; morphogenesis of an epithelial fold; negative regulation of apoptotic process; negative regulation of protein catabolic process; nitric-oxide synthase regulator activity; nuclear membrane; nucleus; perinuclear region of cytoplasm; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAP kinase activity; positive regulation of catenin import into nucleus; positive regulation of cell migration; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of nitric oxide biosynthetic process; positive regulation of protein kinase B signaling cascade; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein autophosphorylation; protein tyrosine kinase activity; regulation of nitric-oxide synthase activity; regulation of peptidyl-tyrosine phosphorylation; response to UV-A; salivary gland morphogenesis IPR011009; IPR000719; IPR001245; Epidermal growth factor receptor (EC 2.7.10.1) (Fragment) EGFR Macaca mulatta (Rhesus macaque) TR43076_c1_g2_i6 Q91287 FGFR3_PLEWA 5.00E-53 GO:0005524; GO:0006915; GO:0005007; GO:0016021; GO:0018108; GO:0005886; GO:0008284; GO:0001501 ATP binding; apoptotic process; fibroblast growth factor-activated receptor activity; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; positive regulation of cell proliferation; skeletal system development IPR028176; IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (PFR3) FGFR3 Pleurodeles waltl (Iberian ribbed newt) TR43076_c1_g2_i8 Q8MY85 FGFR2_DUGJA 2.00E-46 GO:0005524; GO:0016021; GO:0018108; GO:0004714 ATP binding; integral to membrane; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity IPR007110; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 2 (DjFgfr2) (FGFR-2) (EC 2.7.10.1) (DjPTK1) FGFR2 Dugesia japonica (Planarian) TR43077_c0_g1_i1 P18433 PTPRA_HUMAN 3.00E-34 GO:0007411; GO:0008286; GO:0005887; GO:0006468; GO:0005001 P14781; P39688; P62993; P00523; P12931 axon guidance; insulin receptor signaling pathway; integral to plasma membrane; protein phosphorylation; transmembrane receptor protein tyrosine phosphatase activity IPR000387; IPR016130; IPR000242; IPR016336; IPR027262; Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) TR43077_c0_g1_i2 Q64605 PTPRS_RAT 2.00E-28 GO:0007155; GO:0016021; GO:0004725 cell adhesion; integral to membrane; protein tyrosine phosphatase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Leukocyte common antigen-related protein-tyrosine phosphatase 2) (LAR-PTP2) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma) Ptprs Rattus norvegicus (Rat) TR43077_c0_g1_i3 Q64612 PTPRV_RAT 1.00E-24 GO:0046849; GO:0016021; GO:0035335; GO:0004725 bone remodeling; integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR003961; IPR013783; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase V (R-PTP-V) (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase) (Osteotesticular protein-tyrosine phosphatase) (OST-PTP) Ptprv Esp Rattus norvegicus (Rat) TR43077_c0_g1_i8 Q05209 PTN12_HUMAN 2.00E-25 GO:0030054; GO:0042995; GO:0005737; GO:0005829; GO:0004726; GO:0005886; GO:0002102 P56945; P04626; P09619; Q02763 cell junction; cell projection; cytoplasm; cytosol; non-membrane spanning protein tyrosine phosphatase activity; plasma membrane; podosome IPR012266; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) PTPN12 Homo sapiens (Human) TR43077_c0_g1_i9 O35239 PTN9_MOUSE 5.00E-26 GO:0005737; GO:0004725 P46460 cytoplasm; protein tyrosine phosphatase activity IPR001251; IPR011074; IPR000387; IPR016130; IPR000242; Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase MEG2) Ptpn9 Mus musculus (Mouse) TR43077_c0_g2_i1 P59222 SREC2_MOUSE 2.00E-06 GO:0007157; GO:0016021; GO:0005044 heterophilic cell-cell adhesion; integral to membrane; scavenger receptor activity IPR000742; IPR013032; IPR009030; Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) TR43077_c1_g1_i1 Q64487 PTPRD_MOUSE 3.00E-67 GO:0007157; GO:0016021; GO:0030182; GO:0035335; GO:0050775; GO:0097105; GO:0004725 P59823 heterophilic cell-cell adhesion; integral to membrane; neuron differentiation; peptidyl-tyrosine dephosphorylation; positive regulation of dendrite morphogenesis; presynaptic membrane assembly; protein tyrosine phosphatase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48) Ptprd Mus musculus (Mouse) TR43077_c1_g1_i2 Q9IBD8 PTPRC_CYPCA 2.00E-38 GO:0050852; GO:0016021; GO:0035335; GO:0004725 T cell receptor signaling pathway; integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR003961; IPR013783; IPR016335; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (CD antigen CD45) ptprc Cyprinus carpio (Common carp) TR43077_c1_g1_i3 Q5I145 PTPH3_MDBVW 2.00E-16 GO:0035335; GO:0004725; GO:0039503 peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; suppression by virus of host innate immune response IPR000387; IPR016130; IPR000242; Tyrosine phosphatase H3 (PTP-H3) (EC 3.1.3.48) H3 Microplitis demolitor bracovirus (isolate Webb) (MdBV) TR43077_c1_g1_i4 Q64604 PTPRF_RAT 3.00E-40 GO:0005768; GO:0060076; GO:0030426; GO:0008201; GO:0007156; GO:0005158; GO:0016021; GO:0031345; GO:0008285; GO:0001960; GO:0042059; GO:0046627; GO:0051387; GO:0043025; GO:0042301; GO:0005886; GO:0050775; GO:0043525; GO:0050803; GO:0005001 endosome; excitatory synapse; growth cone; heparin binding; homophilic cell adhesion; insulin receptor binding; integral to membrane; negative regulation of cell projection organization; negative regulation of cell proliferation; negative regulation of cytokine-mediated signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of neurotrophin TRK receptor signaling pathway; neuronal cell body; phosphate ion binding; plasma membrane; positive regulation of dendrite morphogenesis; positive regulation of neuron apoptotic process; regulation of synapse structure and activity; transmembrane receptor protein tyrosine phosphatase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) Ptprf Lar Rattus norvegicus (Rat) TR43077_c1_g1_i5 P23469 PTPRE_HUMAN 2.00E-45 GO:0005737; GO:0016021; GO:0045111; GO:0046627; GO:0005634; GO:0005886; GO:0033003; GO:0005001; GO:0007185 cytoplasm; integral to membrane; intermediate filament cytoskeleton; negative regulation of insulin receptor signaling pathway; nucleus; plasma membrane; regulation of mast cell activation; transmembrane receptor protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase signaling pathway IPR000387; IPR016130; IPR000242; IPR016336; Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) TR43080_c4_g3_i1 Q6NZL0 SOGA3_MOUSE 3.00E-19 GO:0005615; GO:0016021; GO:0010506 extracellular space; integral to membrane; regulation of autophagy IPR027881; Protein SOGA3 Soga3 Mus musculus (Mouse) TR43081_c2_g1_i1 Q91XE9 CR3L3_MOUSE 2.00E-26 GO:0005789; GO:0016021; GO:0005634; GO:0006986; GO:0043565; GO:0003700; GO:0006351 "endoplasmic reticulum membrane; integral to membrane; nucleus; response to unfolded protein; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] Creb3l3 Crebh Mus musculus (Mouse) TR43081_c2_g1_i11 Q91XE9 CR3L3_MOUSE 3.00E-26 GO:0005789; GO:0016021; GO:0005634; GO:0006986; GO:0043565; GO:0003700; GO:0006351 "endoplasmic reticulum membrane; integral to membrane; nucleus; response to unfolded protein; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] Creb3l3 Crebh Mus musculus (Mouse) TR43081_c2_g1_i4 Q66HA2 CR3L1_RAT 1.00E-19 GO:0001077; GO:0003682; GO:0005789; GO:0016021; GO:0005634; GO:0030500; GO:0006986; GO:0043565 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; chromatin binding; endoplasmic reticulum membrane; integral to membrane; nucleus; regulation of bone mineralization; response to unfolded protein; sequence-specific DNA binding IPR004827; IPR001630; Cyclic AMP-responsive element-binding protein 3-like protein 1 (cAMP-responsive element-binding protein 3-like protein 1) (Old astrocyte specifically-induced substance) (OASIS) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 1] Creb3l1 Oasis Rattus norvegicus (Rat) TR43081_c2_g1_i5 Q91XE9 CR3L3_MOUSE 2.00E-26 GO:0005789; GO:0016021; GO:0005634; GO:0006986; GO:0043565; GO:0003700; GO:0006351 "endoplasmic reticulum membrane; integral to membrane; nucleus; response to unfolded protein; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] Creb3l3 Crebh Mus musculus (Mouse) TR43081_c2_g1_i9 Q91XE9 CR3L3_MOUSE 2.00E-26 GO:0005789; GO:0016021; GO:0005634; GO:0006986; GO:0043565; GO:0003700; GO:0006351 "endoplasmic reticulum membrane; integral to membrane; nucleus; response to unfolded protein; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] Creb3l3 Crebh Mus musculus (Mouse) TR43082_c1_g2_i1 Q8IUC8 GLT13_HUMAN 4.00E-157 GO:0000139; GO:0016266; GO:0016021; GO:0004653; GO:0043687 Golgi membrane; O-glycan processing; integral to membrane; polypeptide N-acetylgalactosaminyltransferase activity; post-translational protein modification IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 13 (EC 2.4.1.41) (Polypeptide GalNAc transferase 13) (GalNAc-T13) (pp-GaNTase 13) (Protein-UDP acetylgalactosaminyltransferase 13) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13) GALNT13 KIAA1918 Homo sapiens (Human) TR43082_c1_g2_i10 Q8IUC8 GLT13_HUMAN 2.00E-146 GO:0000139; GO:0016266; GO:0016021; GO:0004653; GO:0043687 Golgi membrane; O-glycan processing; integral to membrane; polypeptide N-acetylgalactosaminyltransferase activity; post-translational protein modification IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 13 (EC 2.4.1.41) (Polypeptide GalNAc transferase 13) (GalNAc-T13) (pp-GaNTase 13) (Protein-UDP acetylgalactosaminyltransferase 13) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13) GALNT13 KIAA1918 Homo sapiens (Human) TR43082_c1_g2_i11 Q95ZJ1 GALT5_CAEEL 2.00E-86 GO:0000139; GO:0016021; GO:0004653; GO:0018243 Golgi membrane; integral to membrane; polypeptide N-acetylgalactosaminyltransferase activity; protein O-linked glycosylation via threonine IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 5 (pp-GaNTase 5) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5) gly-5 Y39E4B.12 Caenorhabditis elegans TR43082_c1_g2_i15 Q8IUC8 GLT13_HUMAN 2.00E-151 GO:0000139; GO:0016266; GO:0016021; GO:0004653; GO:0043687 Golgi membrane; O-glycan processing; integral to membrane; polypeptide N-acetylgalactosaminyltransferase activity; post-translational protein modification IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 13 (EC 2.4.1.41) (Polypeptide GalNAc transferase 13) (GalNAc-T13) (pp-GaNTase 13) (Protein-UDP acetylgalactosaminyltransferase 13) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13) GALNT13 KIAA1918 Homo sapiens (Human) TR43082_c1_g2_i2 O08912 GALT1_MOUSE 1.00E-156 GO:0032580; GO:0005576; GO:0016021; GO:0030145; GO:0048471; GO:0004653; GO:0006493; GO:0018242; GO:0018243 Golgi cisterna membrane; extracellular region; integral to membrane; manganese ion binding; perinuclear region of cytoplasm; polypeptide N-acetylgalactosaminyltransferase activity; protein O-linked glycosylation; protein O-linked glycosylation via serine; protein O-linked glycosylation via threonine IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 1 (EC 2.4.1.41) (Polypeptide GalNAc transferase 1) (GalNAc-T1) (pp-GaNTase 1) (Protein-UDP acetylgalactosaminyltransferase 1) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 1 soluble form] Galnt1 Mus musculus (Mouse) TR43082_c1_g2_i5 Q8IUC8 GLT13_HUMAN 9.00E-151 GO:0000139; GO:0016266; GO:0016021; GO:0004653; GO:0043687 Golgi membrane; O-glycan processing; integral to membrane; polypeptide N-acetylgalactosaminyltransferase activity; post-translational protein modification IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 13 (EC 2.4.1.41) (Polypeptide GalNAc transferase 13) (GalNAc-T13) (pp-GaNTase 13) (Protein-UDP acetylgalactosaminyltransferase 13) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13) GALNT13 KIAA1918 Homo sapiens (Human) TR43082_c1_g2_i6 O08912 GALT1_MOUSE 2.00E-146 GO:0032580; GO:0005576; GO:0016021; GO:0030145; GO:0048471; GO:0004653; GO:0006493; GO:0018242; GO:0018243 Golgi cisterna membrane; extracellular region; integral to membrane; manganese ion binding; perinuclear region of cytoplasm; polypeptide N-acetylgalactosaminyltransferase activity; protein O-linked glycosylation; protein O-linked glycosylation via serine; protein O-linked glycosylation via threonine IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 1 (EC 2.4.1.41) (Polypeptide GalNAc transferase 1) (GalNAc-T1) (pp-GaNTase 1) (Protein-UDP acetylgalactosaminyltransferase 1) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 1 soluble form] Galnt1 Mus musculus (Mouse) TR43082_c1_g2_i9 Q8I136 GALT4_CAEEL 1.00E-75 GO:0000139; GO:0016021; GO:0004653; GO:0018243 Golgi membrane; integral to membrane; polypeptide N-acetylgalactosaminyltransferase activity; protein O-linked glycosylation via threonine IPR001173; IPR000772; Protein modification; protein glycosylation. Polypeptide N-acetylgalactosaminyltransferase 4 (pp-GaNTase 4) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 4) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4) gly-4 Y116F11B.12 Caenorhabditis elegans TR43084_c1_g2_i1 O75581 LRP6_HUMAN 6.00E-135 GO:0044332; GO:0021874; GO:0090244; GO:0042813; GO:0034185; GO:0090245; GO:0060349; GO:0046849; GO:0060444; GO:0061310; GO:0044335; GO:0061324; GO:0044340; GO:0042074; GO:0009986; GO:0071397; GO:0021587; GO:0021795; GO:0021987; GO:0060026; GO:0071936; GO:0031410; GO:0071542; GO:0005769; GO:0048596; GO:0042733; GO:0035115; GO:0035116; GO:0030326; GO:0009880; GO:0060059; GO:0005783; GO:0035261; GO:0060325; GO:0021861; GO:0021943; GO:0001947; GO:0016021; GO:0019210; GO:0005041; GO:0060596; GO:0030901; GO:0030917; GO:0050680; GO:0045599; GO:2000151; GO:2000162; GO:2000168; GO:2000164; GO:2000166; GO:2000149; GO:0071901; GO:0034392; GO:0014029; GO:0001843; GO:0043025; GO:0042475; GO:0060021; GO:0003344; GO:0005886; GO:2000055; GO:0043065; GO:0045780; GO:0090263; GO:0045787; GO:0002053; GO:0045778; GO:0051091; GO:0045944; GO:0036342; GO:0090009; GO:0043235; GO:0090118; GO:0060284; GO:0045598; GO:0030278; GO:0051593; GO:0045202; GO:0007268; GO:0021794; GO:0019534; GO:0060535 Q9Y4X0; Q9H6X2; O70239; Q03135; P98082; P49840; P49841; Q5S007; Q9ERE8 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt receptor signaling pathway involved in forebrain neuroblast division; Wnt receptor signaling pathway involved in somitogenesis; Wnt-activated receptor activity; apolipoprotein binding; axis elongation involved in somitogenesis; bone morphogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development; canonical Wnt receptor signaling pathway involved in neural crest cell differentiation; canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; canonical Wnt receptor signaling pathway involved in regulation of cell proliferation; cell migration involved in gastrulation; cell surface; cellular response to cholesterol; cerebellum morphogenesis; cerebral cortex cell migration; cerebral cortex development; convergent extension; coreceptor activity involved in Wnt receptor signaling pathway; cytoplasmic vesicle; dopaminergic neuron differentiation; early endosome; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; embryonic pattern specification; embryonic retina morphogenesis in camera-type eye; endoplasmic reticulum; external genitalia morphogenesis; face morphogenesis; forebrain radial glial cell differentiation; formation of radial glial scaffolds; heart looping; integral to membrane; kinase inhibitor activity; low-density lipoprotein receptor activity; mammary placode formation; midbrain development; midbrain-hindbrain boundary development; negative regulation of epithelial cell proliferation; negative regulation of fat cell differentiation; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis; negative regulation of planar cell polarity pathway involved in neural tube closure; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest formation; neural tube closure; neuronal cell body; odontogenesis of dentin-containing tooth; palate development; pericardium morphogenesis; plasma membrane; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell cycle; positive regulation of mesenchymal cell proliferation; positive regulation of ossification; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; post-anal tail morphogenesis; primitive streak formation; receptor complex; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport; regulation of cell development; regulation of fat cell differentiation; regulation of ossification; response to folic acid; synapse; synaptic transmission; thalamus development; toxin transporter activity; trachea cartilage morphogenesis IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 6 (LRP-6) LRP6 Homo sapiens (Human) TR43084_c1_g2_i4 P01131 LDLR_BOVIN 1.00E-19 GO:0005794; GO:0009986; GO:0008203; GO:0005905; GO:0005769; GO:0006897; GO:0016021; GO:0005770; GO:0006869; GO:0034362; GO:0005764; GO:0005886 Golgi apparatus; cell surface; cholesterol metabolic process; coated pit; early endosome; endocytosis; integral to membrane; late endosome; lipid transport; low-density lipoprotein particle; lysosome; plasma membrane IPR011042; IPR000742; IPR000033; Low-density lipoprotein receptor (LDL receptor) (Fragment) LDLR Bos taurus (Bovine) TR43084_c1_g3_i1 O88572 LRP6_MOUSE 0 GO:0044332; GO:0021874; GO:0090244; GO:0042813; GO:0090245; GO:0046849; GO:0060444; GO:0061310; GO:0061324; GO:0005901; GO:0042074; GO:0009986; GO:0071397; GO:0021587; GO:0021795; GO:0060026; GO:0015026; GO:0071936; GO:0031410; GO:0071542; GO:0005769; GO:0048596; GO:0042733; GO:0035115; GO:0035116; GO:0009880; GO:0060059; GO:0005783; GO:0035261; GO:0060325; GO:0021861; GO:0021943; GO:0001947; GO:0016021; GO:0019210; GO:0005041; GO:0060596; GO:0030901; GO:0030917; GO:0050680; GO:0045599; GO:2000151; GO:2000162; GO:2000168; GO:2000164; GO:2000166; GO:2000149; GO:0071901; GO:0034392; GO:0014029; GO:0001843; GO:0043025; GO:0042475; GO:0060021; GO:0003344; GO:2000055; GO:0043065; GO:0045780; GO:0090263; GO:0045787; GO:0002053; GO:0045778; GO:0051091; GO:0045944; GO:0036342; GO:0090009; GO:0043235; GO:0090118; GO:0060284; GO:0051593; GO:0048705; GO:0045202; GO:0007268; GO:0021794; GO:0019534; GO:0060535 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt receptor signaling pathway involved in forebrain neuroblast division; Wnt receptor signaling pathway involved in somitogenesis; Wnt-activated receptor activity; axis elongation involved in somitogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development; canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; caveola; cell migration involved in gastrulation; cell surface; cellular response to cholesterol; cerebellum morphogenesis; cerebral cortex cell migration; convergent extension; coreceptor activity; coreceptor activity involved in Wnt receptor signaling pathway; cytoplasmic vesicle; dopaminergic neuron differentiation; early endosome; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic pattern specification; embryonic retina morphogenesis in camera-type eye; endoplasmic reticulum; external genitalia morphogenesis; face morphogenesis; forebrain radial glial cell differentiation; formation of radial glial scaffolds; heart looping; integral to membrane; kinase inhibitor activity; low-density lipoprotein receptor activity; mammary placode formation; midbrain development; midbrain-hindbrain boundary development; negative regulation of epithelial cell proliferation; negative regulation of fat cell differentiation; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis; negative regulation of planar cell polarity pathway involved in neural tube closure; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest formation; neural tube closure; neuronal cell body; odontogenesis of dentin-containing tooth; palate development; pericardium morphogenesis; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell cycle; positive regulation of mesenchymal cell proliferation; positive regulation of ossification; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; post-anal tail morphogenesis; primitive streak formation; receptor complex; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport; regulation of cell development; response to folic acid; skeletal system morphogenesis; synapse; synaptic transmission; thalamus development; toxin transporter activity; trachea cartilage morphogenesis IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 6 (LRP-6) Lrp6 Mus musculus (Mouse) TR43084_c1_g3_i3 A4QPB2 LRP5L_HUMAN 3.00E-85 GO:0044332; GO:0042813; GO:0017147; GO:0060070 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt-activated receptor activity; Wnt-protein binding; canonical Wnt receptor signaling pathway IPR011042; IPR000033; Low-density lipoprotein receptor-related protein 5-like protein (LRP-5-like) LRP5L Homo sapiens (Human) TR43085_c0_g1_i3 Q12802 AKP13_HUMAN 1.00E-93 GO:0005089; GO:0097190; GO:0004691; GO:0005829; GO:0016020; GO:0046872; GO:0048011; GO:0005634; GO:0005543; GO:0043065; GO:0035023; GO:1900169; GO:0051056; GO:0004871; GO:0007264 P03372; P21980 Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; cAMP-dependent protein kinase activity; cytosol; membrane; metal ion binding; neurotrophin TRK receptor signaling pathway; nucleus; phospholipid binding; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of glucocorticoid mediated signaling pathway; regulation of small GTPase mediated signal transduction; signal transducer activity; small GTPase mediated signal transduction IPR000219; IPR011993; IPR001849; IPR002219; A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) AKAP13 BRX HT31 LBC Homo sapiens (Human) TR43086_c0_g1_i1 O70167 P3C2G_MOUSE 5.00E-36 GO:0016303; GO:0035005; GO:0005524; GO:0006935; GO:0005942; GO:0035091; GO:0048015; GO:0005886 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; chemotaxis; phosphatidylinositol 3-kinase complex; phosphatidylinositol binding; phosphatidylinositol-mediated signaling; plasma membrane IPR016024; IPR000008; IPR011009; IPR001683; IPR000403; IPR018936; IPR002420; IPR000341; IPR015433; IPR001263; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma (PI3K-C2-gamma) (PtdIns-3-kinase C2 subunit gamma) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-gamma) Pik3c2g Mus musculus (Mouse) TR43086_c0_g1_i2 P42356 PI4KA_HUMAN 0 GO:0004430; GO:0005524; GO:0005798; GO:0005829; GO:0006661; GO:0048015; GO:0005886; GO:0007165; GO:0044281; GO:0007268 1-phosphatidylinositol 4-kinase activity; ATP binding; Golgi-associated vesicle; cytosol; phosphatidylinositol biosynthetic process; phosphatidylinositol-mediated signaling; plasma membrane; signal transduction; small molecule metabolic process; synaptic transmission IPR016024; IPR011009; IPR000403; IPR018936; IPR015433; IPR001263; Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) PI4KA PIK4 PIK4CA Homo sapiens (Human) TR43086_c0_g1_i5 A4QPH2 PI4P2_HUMAN 9.00E-161 GO:0016301; GO:0046854; GO:0048015; GO:0016773 "kinase activity; phosphatidylinositol phosphorylation; phosphatidylinositol-mediated signaling; phosphotransferase activity, alcohol group as acceptor" IPR011009; IPR000403; IPR018936; IPR015433; Putative phosphatidylinositol 4-kinase alpha-like protein P2 PI4KAP2 Homo sapiens (Human) TR43086_c0_g1_i8 Q86C65 TOR_DICDI 4.00E-07 GO:0005524; GO:0031932; GO:0007049; GO:0006935; GO:0008144; GO:0004674 ATP binding; TORC2 complex; cell cycle; chemotaxis; drug binding; protein serine/threonine kinase activity IPR011989; IPR016024; IPR024585; IPR003152; IPR021133; IPR011009; IPR000403; IPR018936; IPR003151; IPR014009; IPR009076; IPR026683; Target of rapamycin (EC 2.7.1.-) tor DDB_G0281569 Dictyostelium discoideum (Slime mold) TR43086_c1_g1_i1 P42356 PI4KA_HUMAN 0 GO:0004430; GO:0005524; GO:0005798; GO:0005829; GO:0006661; GO:0048015; GO:0005886; GO:0007165; GO:0044281; GO:0007268 1-phosphatidylinositol 4-kinase activity; ATP binding; Golgi-associated vesicle; cytosol; phosphatidylinositol biosynthetic process; phosphatidylinositol-mediated signaling; plasma membrane; signal transduction; small molecule metabolic process; synaptic transmission IPR016024; IPR011009; IPR000403; IPR018936; IPR015433; IPR001263; Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) PI4KA PIK4 PIK4CA Homo sapiens (Human) TR43086_c1_g1_i4 Q9SXA1 P4KA1_ARATH 2.00E-16 GO:0004430; GO:0051015; GO:0048471; GO:0070300; GO:0005546; GO:0070273; GO:0048015; GO:0005886; GO:0009506; GO:0006468 "1-phosphatidylinositol 4-kinase activity; actin filament binding; perinuclear region of cytoplasm; phosphatidic acid binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-mediated signaling; plasma membrane; plasmodesma; protein phosphorylation" IPR016024; IPR011009; IPR000403; IPR018936; IPR015433; IPR001263; Phosphatidylinositol 4-kinase alpha 1 (PI4-kinase alpha 1) (PtdIns-4-kinase alpha 1) (EC 2.7.1.67) (Phosphatidylinositol 4-OH kinase alpha1) (AtPI4Kalpha1) (PI-4Kalpha1) PI4KA1 PI4KALPHA PI4KALPHA1 At1g49340 F13F21.23 Arabidopsis thaliana (Mouse-ear cress) TR43086_c1_g2_i1 O02811 PI4KA_BOVIN 3.00E-72 GO:0004430; GO:0005524; GO:0048015 1-phosphatidylinositol 4-kinase activity; ATP binding; phosphatidylinositol-mediated signaling IPR016024; IPR011009; IPR000403; IPR018936; IPR015433; IPR001263; Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) PI4KA PIK4CA Bos taurus (Bovine) TR43087_c0_g1_i1 Q12955 ANK3_HUMAN 6.00E-163 GO:0043001; GO:0030315; GO:0007411; GO:0043194; GO:0007409; GO:0016323; GO:0045296; GO:0009986; GO:0043034; GO:0014704; GO:0044325; GO:0016328; GO:0005764; GO:0072660; GO:0071709; GO:0000281; GO:0033268; GO:0033270; GO:0010628; GO:1900827; GO:0045838; GO:2000651; GO:0010765; GO:0045211; GO:0030674; GO:0072661; GO:0019228; GO:0043266; GO:0007165; GO:0030507; GO:0014731; GO:0005200; GO:0050808 "Golgi to plasma membrane protein transport; T-tubule; axon guidance; axon initial segment; axonogenesis; basolateral plasma membrane; cadherin binding; cell surface; costamere; intercalated disc; ion channel binding; lateral plasma membrane; lysosome; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; node of Ranvier; paranode region of axon; positive regulation of gene expression; positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; postsynaptic membrane; protein binding, bridging; protein targeting to plasma membrane; regulation of action potential in neuron; regulation of potassium ion transport; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton; synapse organization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) TR43087_c0_g1_i13 Q12955 ANK3_HUMAN 3.00E-165 GO:0043001; GO:0030315; GO:0007411; GO:0043194; GO:0007409; GO:0016323; GO:0045296; GO:0009986; GO:0043034; GO:0014704; GO:0044325; GO:0016328; GO:0005764; GO:0072660; GO:0071709; GO:0000281; GO:0033268; GO:0033270; GO:0010628; GO:1900827; GO:0045838; GO:2000651; GO:0010765; GO:0045211; GO:0030674; GO:0072661; GO:0019228; GO:0043266; GO:0007165; GO:0030507; GO:0014731; GO:0005200; GO:0050808 "Golgi to plasma membrane protein transport; T-tubule; axon guidance; axon initial segment; axonogenesis; basolateral plasma membrane; cadherin binding; cell surface; costamere; intercalated disc; ion channel binding; lateral plasma membrane; lysosome; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; node of Ranvier; paranode region of axon; positive regulation of gene expression; positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; postsynaptic membrane; protein binding, bridging; protein targeting to plasma membrane; regulation of action potential in neuron; regulation of potassium ion transport; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton; synapse organization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) TR43087_c0_g1_i14 G5E8K5 ANK3_MOUSE 0 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR43087_c0_g1_i15 Q12955 ANK3_HUMAN 4.00E-171 GO:0043001; GO:0030315; GO:0007411; GO:0043194; GO:0007409; GO:0016323; GO:0045296; GO:0009986; GO:0043034; GO:0014704; GO:0044325; GO:0016328; GO:0005764; GO:0072660; GO:0071709; GO:0000281; GO:0033268; GO:0033270; GO:0010628; GO:1900827; GO:0045838; GO:2000651; GO:0010765; GO:0045211; GO:0030674; GO:0072661; GO:0019228; GO:0043266; GO:0007165; GO:0030507; GO:0014731; GO:0005200; GO:0050808 "Golgi to plasma membrane protein transport; T-tubule; axon guidance; axon initial segment; axonogenesis; basolateral plasma membrane; cadherin binding; cell surface; costamere; intercalated disc; ion channel binding; lateral plasma membrane; lysosome; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; node of Ranvier; paranode region of axon; positive regulation of gene expression; positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; postsynaptic membrane; protein binding, bridging; protein targeting to plasma membrane; regulation of action potential in neuron; regulation of potassium ion transport; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton; synapse organization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) TR43087_c0_g1_i16 G5E8K5 ANK3_MOUSE 0 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR43087_c0_g1_i2 G5E8K5 ANK3_MOUSE 0 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR43087_c0_g1_i3 Q12955 ANK3_HUMAN 2.00E-165 GO:0043001; GO:0030315; GO:0007411; GO:0043194; GO:0007409; GO:0016323; GO:0045296; GO:0009986; GO:0043034; GO:0014704; GO:0044325; GO:0016328; GO:0005764; GO:0072660; GO:0071709; GO:0000281; GO:0033268; GO:0033270; GO:0010628; GO:1900827; GO:0045838; GO:2000651; GO:0010765; GO:0045211; GO:0030674; GO:0072661; GO:0019228; GO:0043266; GO:0007165; GO:0030507; GO:0014731; GO:0005200; GO:0050808 "Golgi to plasma membrane protein transport; T-tubule; axon guidance; axon initial segment; axonogenesis; basolateral plasma membrane; cadherin binding; cell surface; costamere; intercalated disc; ion channel binding; lateral plasma membrane; lysosome; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; node of Ranvier; paranode region of axon; positive regulation of gene expression; positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; postsynaptic membrane; protein binding, bridging; protein targeting to plasma membrane; regulation of action potential in neuron; regulation of potassium ion transport; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton; synapse organization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) TR43087_c0_g1_i4 G5E8K5 ANK3_MOUSE 5.00E-178 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR43087_c0_g1_i5 G5E8K5 ANK3_MOUSE 0 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR43087_c0_g1_i9 G5E8K5 ANK3_MOUSE 0 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR43088_c5_g1_i1 Q95116 TSP2_BOVIN 3.00E-16 GO:0005509; GO:0007155; GO:0005576; GO:0008201 calcium ion binding; cell adhesion; extracellular region; heparin binding IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR024731; IPR001791; IPR000884; IPR015455; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-2 (Corticotropin-induced secreted protein) (CISP) THBS2 TSP-2 TSP2 Bos taurus (Bovine) TR43089_c2_g1_i1 Q9JHW1 CBPD_RAT 4.00E-43 GO:0071352; GO:0016021; GO:0004181; GO:0005634; GO:0005886; GO:0006508; GO:0004185; GO:0005802; GO:0008270 cellular response to interleukin-2; integral to membrane; metallocarboxypeptidase activity; nucleus; plasma membrane; proteolysis; serine-type carboxypeptidase activity; trans-Golgi network; zinc ion binding IPR008969; IPR014766; IPR015567; IPR000834; Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180) Cpd Rattus norvegicus (Rat) TR43089_c2_g1_i2 Q90240 CBPD_ANAPL 2.00E-69 GO:0016021; GO:0004181; GO:0006508; GO:0004185; GO:0008270 integral to membrane; metallocarboxypeptidase activity; proteolysis; serine-type carboxypeptidase activity; zinc ion binding IPR008969; IPR014766; IPR015567; IPR000834; Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180) (p170) CPD Anas platyrhynchos (Domestic duck) (Anas boschas) TR43091_c3_g3_i2 O60264 SMCA5_HUMAN 0 GO:0005524; GO:0016887; GO:0034080; GO:0003677; GO:0006352; GO:0016589; GO:0031213; GO:0003682; GO:0000183; GO:0005677; GO:0000793; GO:0006302; GO:0009790; GO:0004386; GO:0005730; GO:0005654; GO:0016584; GO:0045893; GO:0006357 Q9UIG0; P62805; Q96T23 "ATP binding; ATPase activity; CENP-A containing nucleosome assembly at centromere; DNA binding; DNA-dependent transcription, initiation; NURF complex; RSF complex; chromatin binding; chromatin silencing at rDNA; chromatin silencing complex; condensed chromosome; double-strand break repair; embryo development; helicase activity; nucleolus; nucleoplasm; nucleosome positioning; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter" IPR020838; IPR014001; IPR001650; IPR009057; IPR015194; IPR027417; IPR001005; IPR017884; IPR015195; IPR000330; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) SMARCA5 SNF2H WCRF135 Homo sapiens (Human) TR43094_c1_g1_i1 P49792 RBP2_HUMAN 5.00E-39 GO:0008536; GO:0005975; GO:0019221; GO:0005829; GO:0015758; GO:0016874; GO:0051028; GO:0007077; GO:0042405; GO:0031965; GO:0044615; GO:0003755; GO:0006457; GO:0006606; GO:0000413; GO:0016925; GO:0010827; GO:0044281; GO:0055085; GO:0016032; GO:0008270 P04626; O60260; Q53GG5 Ran GTPase binding; carbohydrate metabolic process; cytokine-mediated signaling pathway; cytosol; glucose transport; ligase activity; mRNA transport; mitotic nuclear envelope disassembly; nuclear inclusion body; nuclear membrane; nuclear pore nuclear basket; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein import into nucleus; protein peptidyl-prolyl isomerization; protein sumoylation; regulation of glucose transport; small molecule metabolic process; transmembrane transport; viral process; zinc ion binding IPR002130; IPR020892; IPR022011; IPR011993; IPR000156; IPR013026; IPR011990; IPR001440; IPR019734; IPR001876; Protein modification; protein sumoylation. E3 SUMO-protein ligase RanBP2 (EC 6.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) RANBP2 NUP358 Homo sapiens (Human) TR43094_c1_g4_i1 P49791 NU153_RAT 1.00E-10 GO:0003677; GO:0051028; GO:0046832; GO:0042405; GO:0005652; GO:0031965; GO:0051292; GO:0044615; GO:0005487; GO:0043495; GO:0015031; GO:0017056; GO:0008270 DNA binding; mRNA transport; negative regulation of RNA export from nucleus; nuclear inclusion body; nuclear lamina; nuclear membrane; nuclear pore complex assembly; nuclear pore nuclear basket; nucleocytoplasmic transporter activity; protein anchor; protein transport; structural constituent of nuclear pore; zinc ion binding IPR026054; IPR013913; IPR018892; IPR001876; Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) Nup153 Rattus norvegicus (Rat) TR43095_c0_g1_i1 Q8IVL1 NAV2_HUMAN 0 GO:0005524; GO:0021563; GO:0004386; GO:0008201; GO:0005614; GO:0007626; GO:0005634; GO:0021554; GO:0003025; GO:0007608; GO:0007605; GO:0021564 ATP binding; glossopharyngeal nerve development; helicase activity; heparin binding; interstitial matrix; locomotory behavior; nucleus; optic nerve development; regulation of systemic arterial blood pressure by baroreceptor feedback; sensory perception of smell; sensory perception of sound; vagus nerve development IPR003593; IPR001715; IPR027417; Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2 Homo sapiens (Human) TR43095_c0_g1_i2 Q7YSI9 UNC53_CAEEL 3.00E-51 GO:0030036; GO:0051015; GO:0007411; GO:0043057; GO:0005737; GO:0016204; GO:0007617; GO:0008078; GO:0018991; GO:0045773; GO:0030335; GO:0040018; GO:0007165 actin cytoskeleton organization; actin filament binding; axon guidance; backward locomotion; cytoplasm; determination of muscle attachment site; mating behavior; mesodermal cell migration; oviposition; positive regulation of axon extension; positive regulation of cell migration; positive regulation of multicellular organism growth; signal transduction IPR001715; IPR027417; Adapter protein unc-53 (Uncoordinated protein 53) unc-53 F45E10.1 Caenorhabditis elegans TR43095_c0_g1_i3 Q8IVL1 NAV2_HUMAN 0 GO:0005524; GO:0021563; GO:0004386; GO:0008201; GO:0005614; GO:0007626; GO:0005634; GO:0021554; GO:0003025; GO:0007608; GO:0007605; GO:0021564 ATP binding; glossopharyngeal nerve development; helicase activity; heparin binding; interstitial matrix; locomotory behavior; nucleus; optic nerve development; regulation of systemic arterial blood pressure by baroreceptor feedback; sensory perception of smell; sensory perception of sound; vagus nerve development IPR003593; IPR001715; IPR027417; Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2 Homo sapiens (Human) TR43095_c0_g1_i5 Q8IVL1 NAV2_HUMAN 0 GO:0005524; GO:0021563; GO:0004386; GO:0008201; GO:0005614; GO:0007626; GO:0005634; GO:0021554; GO:0003025; GO:0007608; GO:0007605; GO:0021564 ATP binding; glossopharyngeal nerve development; helicase activity; heparin binding; interstitial matrix; locomotory behavior; nucleus; optic nerve development; regulation of systemic arterial blood pressure by baroreceptor feedback; sensory perception of smell; sensory perception of sound; vagus nerve development IPR003593; IPR001715; IPR027417; Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2 Homo sapiens (Human) TR43095_c0_g1_i7 Q8IVL1 NAV2_HUMAN 0 GO:0005524; GO:0021563; GO:0004386; GO:0008201; GO:0005614; GO:0007626; GO:0005634; GO:0021554; GO:0003025; GO:0007608; GO:0007605; GO:0021564 ATP binding; glossopharyngeal nerve development; helicase activity; heparin binding; interstitial matrix; locomotory behavior; nucleus; optic nerve development; regulation of systemic arterial blood pressure by baroreceptor feedback; sensory perception of smell; sensory perception of sound; vagus nerve development IPR003593; IPR001715; IPR027417; Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2 Homo sapiens (Human) TR43095_c0_g1_i8 Q7YSI9 UNC53_CAEEL 3.00E-51 GO:0030036; GO:0051015; GO:0007411; GO:0043057; GO:0005737; GO:0016204; GO:0007617; GO:0008078; GO:0018991; GO:0045773; GO:0030335; GO:0040018; GO:0007165 actin cytoskeleton organization; actin filament binding; axon guidance; backward locomotion; cytoplasm; determination of muscle attachment site; mating behavior; mesodermal cell migration; oviposition; positive regulation of axon extension; positive regulation of cell migration; positive regulation of multicellular organism growth; signal transduction IPR001715; IPR027417; Adapter protein unc-53 (Uncoordinated protein 53) unc-53 F45E10.1 Caenorhabditis elegans TR43095_c0_g1_i9 Q8IVL1 NAV2_HUMAN 0 GO:0005524; GO:0021563; GO:0004386; GO:0008201; GO:0005614; GO:0007626; GO:0005634; GO:0021554; GO:0003025; GO:0007608; GO:0007605; GO:0021564 ATP binding; glossopharyngeal nerve development; helicase activity; heparin binding; interstitial matrix; locomotory behavior; nucleus; optic nerve development; regulation of systemic arterial blood pressure by baroreceptor feedback; sensory perception of smell; sensory perception of sound; vagus nerve development IPR003593; IPR001715; IPR027417; Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2 Homo sapiens (Human) TR43096_c0_g1_i1 Q1RLX4 TPC11_DANRE 0 GO:0005794; GO:0001889; GO:0060041; GO:0016192 Golgi apparatus; liver development; retina development in camera-type eye; vesicle-mediated transport IPR012880; IPR021773; Trafficking protein particle complex subunit 11 (Protein foie gras) trappc11 fgr foigr zgc:136723 zgc:63684 Danio rerio (Zebrafish) (Brachydanio rerio) TR43096_c0_g1_i2 Q5ZI89 TPC11_CHICK 2.00E-109 GO:0005794; GO:0016192 Golgi apparatus; vesicle-mediated transport IPR012880; IPR021773; Trafficking protein particle complex subunit 11 TRAPPC11 RCJMB04_29e4 Gallus gallus (Chicken) TR43099_c0_g2_i1 P35918 VGFR2_MOUSE 8.00E-08 GO:0005524; GO:0060837; GO:0048754; GO:0055074; GO:0035584; GO:0045165; GO:0030054; GO:0048469; GO:0002042; GO:0016023; GO:0005769; GO:0035162; GO:0003157; GO:0009897; GO:0005576; GO:0005887; GO:0048286; GO:0001945; GO:2000352; GO:0005634; GO:0001541; GO:0038083; GO:0030513; GO:0070374; GO:0045766; GO:0010595; GO:0001938; GO:0002053; GO:0051770; GO:0014068; GO:0001934; GO:0030949; GO:2001214; GO:0043129; GO:0048010; GO:0005021; GO:0001570 P35917; P08581; P16056 ATP binding; blood vessel endothelial cell differentiation; branching morphogenesis of an epithelial tube; calcium ion homeostasis; calcium-mediated signaling using intracellular calcium source; cell fate commitment; cell junction; cell maturation; cell migration involved in sprouting angiogenesis; cytoplasmic membrane-bounded vesicle; early endosome; embryonic hemopoiesis; endocardium development; external side of plasma membrane; extracellular region; integral to plasma membrane; lung alveolus development; lymph vessel development; negative regulation of endothelial cell apoptotic process; nucleus; ovarian follicle development; peptidyl-tyrosine autophosphorylation; positive regulation of BMP signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of angiogenesis; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of phosphatidylinositol 3-kinase cascade; positive regulation of protein phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of vasculogenesis; surfactant homeostasis; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor-activated receptor activity; vasculogenesis IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR013106; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR001824; IPR009136; Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase NYK) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309) Kdr Flk-1 Flk1 Mus musculus (Mouse) TR43099_c0_g2_i2 O01761 UNC89_CAEEL 4.00E-80 GO:0005524; GO:0031430; GO:0005089; GO:0005543; GO:0004672; GO:0035023; GO:0030241 ATP binding; M band; Rho guanyl-nucleotide exchange factor activity; phospholipid binding; protein kinase activity; regulation of Rho protein signal transduction; skeletal muscle myosin thick filament assembly IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR007850; IPR001452; Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans TR43099_c0_g2_i3 Q86TC9 MYPN_HUMAN 7.00E-57 GO:0031674; GO:0030018; GO:0015630; GO:0005634; GO:0045214 P20929 I band; Z disc; microtubule cytoskeleton; nucleus; sarcomere organization IPR007110; IPR013783; IPR013098; IPR003598; Myopalladin (145 kDa sarcomeric protein) MYPN MYOP Homo sapiens (Human) TR43099_c0_g2_i5 Q9I7U4 TITIN_DROME 5.00E-64 GO:0030018; GO:0003779; GO:0051301; GO:0000794; GO:0040011; GO:0007498; GO:0005875; GO:0007076; GO:0016203; GO:0007520; GO:0035206; GO:0045214; GO:0007062; GO:0007519; GO:0007525; GO:0008307; GO:0007522 Z disc; actin binding; cell division; condensed nuclear chromosome; locomotion; mesoderm development; microtubule associated complex; mitotic chromosome condensation; muscle attachment; myoblast fusion; regulation of hemocyte proliferation; sarcomere organization; sister chromatid cohesion; skeletal muscle tissue development; somatic muscle development; structural constituent of muscle; visceral muscle development IPR010939; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR001452; Titin (D-Titin) (Kettin) sls titin CG1915 Drosophila melanogaster (Fruit fly) TR4310_c0_g1_i1 Q568B7 GTDC1_DANRE 1.00E-16 GO:0009058; GO:0016757 "biosynthetic process; transferase activity, transferring glycosyl groups" IPR001296; IPR022701; Glycosyltransferase-like domain-containing protein 1 gtdc1 si:dkey-52o2.3 zgc:110568 Danio rerio (Zebrafish) (Brachydanio rerio) TR43100_c2_g1_i1 Q7KRY7 LAP4_DROME 5.00E-77 GO:0072002; GO:0007464; GO:0030714; GO:0016327; GO:0016323; GO:0060581; GO:0001708; GO:0000902; GO:0007391; GO:0045198; GO:0001737; GO:0016332; GO:0016336; GO:0005576; GO:0045169; GO:0005179; GO:0016328; GO:0050680; GO:0045571; GO:0000122; GO:0031594; GO:0042048; GO:0007318; GO:0045823; GO:0046425; GO:0008593; GO:0051726; GO:0030100; GO:0042058; GO:0050803; GO:0007608; GO:0005918; GO:0019991; GO:0048863; GO:0072089; GO:0005923; GO:0045186 Q4AB30 "Malpighian tubule development; R3/R4 cell fate commitment; anterior/posterior axis specification, follicular epithelium; apicolateral plasma membrane; basolateral plasma membrane; cell fate commitment involved in pattern specification; cell fate specification; cell morphogenesis; dorsal closure; establishment of epithelial cell apical/basal polarity; establishment of imaginal disc-derived wing hair orientation; establishment or maintenance of polarity of embryonic epithelium; establishment or maintenance of polarity of larval imaginal disc epithelium; extracellular region; fusome; hormone activity; lateral plasma membrane; negative regulation of epithelial cell proliferation; negative regulation of imaginal disc growth; negative regulation of transcription from RNA polymerase II promoter; neuromuscular junction; olfactory behavior; pole plasm protein localization; positive regulation of heart contraction; regulation of JAK-STAT cascade; regulation of Notch signaling pathway; regulation of cell cycle; regulation of endocytosis; regulation of epidermal growth factor receptor signaling pathway; regulation of synapse structure and activity; sensory perception of smell; septate junction; septate junction assembly; stem cell differentiation; stem cell proliferation; tight junction; zonula adherens assembly" IPR001611; IPR025875; IPR001478; Protein lap4 (Protein scribble) (Protein smell-impaired) scrib smi vart CG5462 Drosophila melanogaster (Fruit fly) TR43100_c2_g3_i1 Q4H4B6 SCRIB_DANRE 3.00E-74 GO:0032863; GO:0060561; GO:0008283; GO:0005913; GO:0016337; GO:0060027; GO:0005737; GO:0035089; GO:0000132; GO:0045930; GO:0001764; GO:0005886; GO:0050918; GO:0043065; GO:0014021 activation of Rac GTPase activity; apoptotic process involved in morphogenesis; cell proliferation; cell-cell adherens junction; cell-cell adhesion; convergent extension involved in gastrulation; cytoplasm; establishment of apical/basal cell polarity; establishment of mitotic spindle orientation; negative regulation of mitotic cell cycle; neuron migration; plasma membrane; positive chemotaxis; positive regulation of apoptotic process; secondary neural tube formation IPR001611; IPR025875; IPR003591; IPR001478; Protein scribble homolog (Scribble1) scrib llk scrb1 Danio rerio (Zebrafish) (Brachydanio rerio) TR43100_c2_g3_i2 Q4H4B6 SCRIB_DANRE 2.00E-66 GO:0032863; GO:0060561; GO:0008283; GO:0005913; GO:0016337; GO:0060027; GO:0005737; GO:0035089; GO:0000132; GO:0045930; GO:0001764; GO:0005886; GO:0050918; GO:0043065; GO:0014021 activation of Rac GTPase activity; apoptotic process involved in morphogenesis; cell proliferation; cell-cell adherens junction; cell-cell adhesion; convergent extension involved in gastrulation; cytoplasm; establishment of apical/basal cell polarity; establishment of mitotic spindle orientation; negative regulation of mitotic cell cycle; neuron migration; plasma membrane; positive chemotaxis; positive regulation of apoptotic process; secondary neural tube formation IPR001611; IPR025875; IPR003591; IPR001478; Protein scribble homolog (Scribble1) scrib llk scrb1 Danio rerio (Zebrafish) (Brachydanio rerio) TR43100_c2_g3_i5 Q4H4B6 SCRIB_DANRE 2.00E-66 GO:0032863; GO:0060561; GO:0008283; GO:0005913; GO:0016337; GO:0060027; GO:0005737; GO:0035089; GO:0000132; GO:0045930; GO:0001764; GO:0005886; GO:0050918; GO:0043065; GO:0014021 activation of Rac GTPase activity; apoptotic process involved in morphogenesis; cell proliferation; cell-cell adherens junction; cell-cell adhesion; convergent extension involved in gastrulation; cytoplasm; establishment of apical/basal cell polarity; establishment of mitotic spindle orientation; negative regulation of mitotic cell cycle; neuron migration; plasma membrane; positive chemotaxis; positive regulation of apoptotic process; secondary neural tube formation IPR001611; IPR025875; IPR003591; IPR001478; Protein scribble homolog (Scribble1) scrib llk scrb1 Danio rerio (Zebrafish) (Brachydanio rerio) TR43100_c2_g3_i7 Q8VBX6 MPDZ_MOUSE 6.00E-13 GO:0043220; GO:0016324; GO:0007155; GO:0031410; GO:0030425; GO:0042552; GO:0014069; GO:0045211; GO:0005923 O88551 Schmidt-Lanterman incisure; apical plasma membrane; cell adhesion; cytoplasmic vesicle; dendrite; myelination; postsynaptic density; postsynaptic membrane; tight junction IPR004172; IPR015132; IPR001478; Multiple PDZ domain protein (Multi-PDZ domain protein 1) Mpdz Mupp1 Mus musculus (Mouse) TR43100_c2_g3_i8 Q5PYH7 DLG2_DANRE 8.00E-26 GO:0010923; GO:0050808; GO:0007268 negative regulation of phosphatase activity; synapse organization; synaptic transmission IPR008145; IPR008144; IPR020590; IPR016313; IPR019590; IPR027417; IPR001478; IPR019583; IPR011511; IPR001452; Disks large homolog 2 (Postsynaptic density protein 93) (PSD-93) dlg2 Danio rerio (Zebrafish) (Brachydanio rerio) TR43100_c2_g5_i2 Q4H4B6 SCRIB_DANRE 9.00E-99 GO:0032863; GO:0060561; GO:0008283; GO:0005913; GO:0016337; GO:0060027; GO:0005737; GO:0035089; GO:0000132; GO:0045930; GO:0001764; GO:0005886; GO:0050918; GO:0043065; GO:0014021 activation of Rac GTPase activity; apoptotic process involved in morphogenesis; cell proliferation; cell-cell adherens junction; cell-cell adhesion; convergent extension involved in gastrulation; cytoplasm; establishment of apical/basal cell polarity; establishment of mitotic spindle orientation; negative regulation of mitotic cell cycle; neuron migration; plasma membrane; positive chemotaxis; positive regulation of apoptotic process; secondary neural tube formation IPR001611; IPR025875; IPR003591; IPR001478; Protein scribble homolog (Scribble1) scrib llk scrb1 Danio rerio (Zebrafish) (Brachydanio rerio) TR43101_c1_g1_i1 P20742 PZP_HUMAN 1.00E-114 GO:0004866; GO:0005615; GO:0070062; GO:0007565; GO:0004867 endopeptidase inhibitor activity; extracellular space; extracellular vesicular exosome; female pregnancy; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; IPR010916; Pregnancy zone protein (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6) PZP CPAMD6 Homo sapiens (Human) TR43101_c1_g1_i2 P14046 A1I3_RAT 5.00E-71 GO:0005615; GO:0006954; GO:0010951; GO:0030414; GO:0004867 extracellular space; inflammatory response; negative regulation of endopeptidase activity; peptidase inhibitor activity; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; IPR010916; Alpha-1-inhibitor 3 (Alpha-1-inhibitor 3 variant II) (Alpha-1-inhibitor III) A1i3 Mug1 Rattus norvegicus (Rat) TR43101_c1_g2_i1 A8K2U0 A2ML1_HUMAN 2.00E-56 GO:0005615; GO:0010951; GO:0030414; GO:0004867 extracellular space; negative regulation of endopeptidase activity; peptidase inhibitor activity; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; Alpha-2-macroglobulin-like protein 1 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9) A2ML1 CPAMD9 Homo sapiens (Human) TR43101_c1_g2_i3 Q6IE36 OVOS2_HUMAN 1.00E-41 GO:0005615; GO:0010951; GO:0004867 extracellular space; negative regulation of endopeptidase activity; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019565; IPR008930; Ovostatin homolog 2 OVOS2 Homo sapiens (Human) TR43101_c1_g2_i4 P01024 CO3_HUMAN 1.00E-22 GO:0031715; GO:0007186; GO:0006957; GO:0006958; GO:0004866; GO:0005615; GO:0070062; GO:0006631; GO:0006954; GO:0010951; GO:0005886; GO:0045745; GO:0001970; GO:0045766; GO:0010828; GO:0010884; GO:0050766; GO:0001934; GO:0001798; GO:0010575; GO:0030449; GO:0010866 P08603; Q9Y279-1; Q9Y279-2 "C5L2 anaphylatoxin chemotactic receptor binding; G-protein coupled receptor signaling pathway; complement activation, alternative pathway; complement activation, classical pathway; endopeptidase inhibitor activity; extracellular space; extracellular vesicular exosome; fatty acid metabolic process; inflammatory response; negative regulation of endopeptidase activity; plasma membrane; positive regulation of G-protein coupled receptor protein signaling pathway; positive regulation of activation of membrane attack complex; positive regulation of angiogenesis; positive regulation of glucose transport; positive regulation of lipid storage; positive regulation of phagocytosis; positive regulation of protein phosphorylation; positive regulation of type IIa hypersensitivity; positive regulation vascular endothelial growth factor production; regulation of complement activation; regulation of triglyceride biosynthetic process" IPR009048; IPR011626; IPR002890; IPR011625; IPR000020; IPR018081; IPR001840; IPR001599; IPR019742; IPR019565; IPR001134; IPR018933; IPR008930; IPR008993; Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2] C3 CPAMD1 Homo sapiens (Human) TR43101_c1_g2_i5 Q6YHK3 CD109_HUMAN 1.00E-06 GO:0031225; GO:0005615; GO:0010951; GO:0005886; GO:0004867 anchored to membrane; extracellular space; negative regulation of endopeptidase activity; plasma membrane; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) TR43101_c1_g2_i6 A8K2U0 A2ML1_HUMAN 1.00E-16 GO:0005615; GO:0010951; GO:0030414; GO:0004867 extracellular space; negative regulation of endopeptidase activity; peptidase inhibitor activity; serine-type endopeptidase inhibitor activity IPR009048; IPR011626; IPR002890; IPR011625; IPR014756; IPR001599; IPR019742; IPR019565; IPR008930; Alpha-2-macroglobulin-like protein 1 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9) A2ML1 CPAMD9 Homo sapiens (Human) TR43103_c1_g3_i1 Q6CP93 YOP1_KLULA 1.00E-32 GO:0016021 integral to membrane IPR004345; Protein YOP1 YOP1 KLLA0E06578g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) TR43103_c1_g3_i2 Q29RM3 REEP5_BOVIN 5.00E-63 GO:0016021 integral to membrane IPR004345; Receptor expression-enhancing protein 5 REEP5 Bos taurus (Bovine) TR43104_c0_g1_i1 P11046 LAMB1_DROME 8.00E-114 GO:0005605; GO:0070831; GO:0007155; GO:0016477; GO:0050829; GO:0008406; GO:0045089 basal lamina; basement membrane assembly; cell adhesion; cell migration; defense response to Gram-negative bacterium; gonad development; positive regulation of innate immune response IPR013032; IPR002049; IPR013015; IPR008211; Laminin subunit beta-1 (Laminin B1 chain) LanB1 lamB1 CG7123 Drosophila melanogaster (Fruit fly) TR43104_c0_g1_i4 Q24567 NETA_DROME 1.00E-36 GO:0070983; GO:0008347; GO:0008045; GO:0005578; GO:2000289 dendrite guidance; glial cell migration; motor neuron axon guidance; proteinaceous extracellular matrix; regulation of photoreceptor cell axon guidance IPR002049; IPR008211; IPR001134; IPR018933; IPR008993; Netrin-A NetA CG18657 Drosophila melanogaster (Fruit fly) TR43104_c0_g1_i5 Q25092 LAMB_HIRME 3.00E-62 GO:0005578 proteinaceous extracellular matrix IPR002049; Laminin subunit B (Fragment) Hirudo medicinalis (Medicinal leech) TR43104_c0_g1_i7 Q61292 LAMB2_MOUSE 2.00E-82 GO:0014044; GO:0014002; GO:0048677; GO:0007411; GO:0007155; GO:0005608; GO:0072274; GO:0072249; GO:0007528; GO:0060041; GO:0045202; GO:0007601 Schwann cell development; astrocyte development; axon extension involved in regeneration; axon guidance; cell adhesion; laminin-3 complex; metanephric glomerular basement membrane development; metanephric glomerular visceral epithelial cell development; neuromuscular junction development; retina development in camera-type eye; synapse; visual perception IPR002049; IPR013015; IPR008211; Laminin subunit beta-2 (Laminin-11 subunit beta) (Laminin-14 subunit beta) (Laminin-15 subunit beta) (Laminin-3 subunit beta) (Laminin-4 subunit beta) (Laminin-7 subunit beta) (Laminin-9 subunit beta) (S-laminin subunit beta) (S-LAM beta) Lamb2 Lams Mus musculus (Mouse) TR43104_c0_g1_i8 P11046 LAMB1_DROME 8.00E-114 GO:0005605; GO:0070831; GO:0007155; GO:0016477; GO:0050829; GO:0008406; GO:0045089 basal lamina; basement membrane assembly; cell adhesion; cell migration; defense response to Gram-negative bacterium; gonad development; positive regulation of innate immune response IPR013032; IPR002049; IPR013015; IPR008211; Laminin subunit beta-1 (Laminin B1 chain) LanB1 lamB1 CG7123 Drosophila melanogaster (Fruit fly) TR43104_c0_g2_i1 P07942 LAMB1_HUMAN 0 GO:0007411; GO:0007566; GO:0030198; GO:0005201; GO:0005615; GO:0070062; GO:0043208; GO:0005606; GO:0043259; GO:0005607; GO:0043257; GO:0007162; GO:0021812; GO:0042476; GO:0048471; GO:0030335; GO:0050679; GO:0034446 axon guidance; embryo implantation; extracellular matrix organization; extracellular matrix structural constituent; extracellular space; extracellular vesicular exosome; glycosphingolipid binding; laminin-1 complex; laminin-10 complex; laminin-2 complex; laminin-8 complex; negative regulation of cell adhesion; neuronal-glial interaction involved in cerebral cortex radial glia guided migration; odontogenesis; perinuclear region of cytoplasm; positive regulation of cell migration; positive regulation of epithelial cell proliferation; substrate adhesion-dependent cell spreading IPR002049; IPR013015; IPR008211; IPR009053; Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) LAMB1 Homo sapiens (Human) TR43104_c0_g2_i2 Q01635 LAMB1_CHICK 5.00E-74 GO:0005201; GO:0005615; GO:0005606; GO:0043259; GO:0005607; GO:0043257; GO:0007162; GO:0031175; GO:0048471; GO:0030335; GO:0034446 extracellular matrix structural constituent; extracellular space; laminin-1 complex; laminin-10 complex; laminin-2 complex; laminin-8 complex; negative regulation of cell adhesion; neuron projection development; perinuclear region of cytoplasm; positive regulation of cell migration; substrate adhesion-dependent cell spreading IPR002049; IPR008211; Laminin subunit beta-1 (Laminin beta-1-1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) (Fragment) LAMB1 Gallus gallus (Chicken) TR43104_c0_g2_i3 P07942 LAMB1_HUMAN 0 GO:0007411; GO:0007566; GO:0030198; GO:0005201; GO:0005615; GO:0070062; GO:0043208; GO:0005606; GO:0043259; GO:0005607; GO:0043257; GO:0007162; GO:0021812; GO:0042476; GO:0048471; GO:0030335; GO:0050679; GO:0034446 axon guidance; embryo implantation; extracellular matrix organization; extracellular matrix structural constituent; extracellular space; extracellular vesicular exosome; glycosphingolipid binding; laminin-1 complex; laminin-10 complex; laminin-2 complex; laminin-8 complex; negative regulation of cell adhesion; neuronal-glial interaction involved in cerebral cortex radial glia guided migration; odontogenesis; perinuclear region of cytoplasm; positive regulation of cell migration; positive regulation of epithelial cell proliferation; substrate adhesion-dependent cell spreading IPR002049; IPR013015; IPR008211; IPR009053; Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) LAMB1 Homo sapiens (Human) TR43107_c0_g2_i1 Q6P6Z0 DDB1_XENLA 2.00E-15 GO:0031464; GO:0031465; GO:0003677; GO:0006281; GO:0005737; GO:0005634; GO:0043161; GO:0016567 Cul4A-RING ubiquitin ligase complex; Cul4B-RING ubiquitin ligase complex; DNA binding; DNA repair; cytoplasm; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination IPR004871; IPR015943; IPR017986; Protein modification; protein ubiquitination. DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1) ddb1 Xenopus laevis (African clawed frog) TR43107_c0_g2_i3 Q9XYZ5 DDB1_DROME 1.00E-12 GO:0003677; GO:0006281; GO:0005737; GO:0050832; GO:0007307; GO:0007095; GO:0005634; GO:0043161; GO:0042787; GO:0035220 DNA binding; DNA repair; cytoplasm; defense response to fungus; eggshell chorion gene amplification; mitotic G2 DNA damage checkpoint; nucleus; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; wing disc development IPR004871; IPR017986; Protein modification; protein ubiquitination. DNA damage-binding protein 1 (D-DDB1) (Damage-specific DNA-binding protein 1) (Protein piccolo) pic DDB1 CG7769 Drosophila melanogaster (Fruit fly) TR43107_c0_g3_i2 Q10569 CPSF1_BOVIN 0 GO:0003730; GO:0006379; GO:0005847; GO:0006378 mRNA 3'-UTR binding; mRNA cleavage; mRNA cleavage and polyadenylation specificity factor complex; mRNA polyadenylation IPR004871; Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) CPSF1 CPSF160 Bos taurus (Bovine) TR43109_c1_g1_i1 O88307 SORL_MOUSE 3.00E-36 GO:0005794; GO:0008203; GO:0006897; GO:0005768; GO:0016021; GO:0006869; GO:0034362; GO:0030169; GO:0007275; GO:0048471 Golgi apparatus; cholesterol metabolic process; endocytosis; endosome; integral to membrane; lipid transport; low-density lipoprotein particle; low-density lipoprotein particle binding; multicellular organismal development; perinuclear region of cytoplasm IPR011042; IPR003961; IPR013783; IPR023415; IPR000033; IPR002172; IPR006581; Sortilin-related receptor (Gp250) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) Sorl1 Mus musculus (Mouse) TR43109_c1_g1_i2 P98156 VLDLR_MOUSE 3.00E-164 GO:0005509; GO:0008203; GO:0005905; GO:0005615; GO:0034436; GO:0034437; GO:0016021; GO:0006869; GO:0016020; GO:0000122; GO:1900006; GO:0045860; GO:0038025; GO:0021517; GO:0034361; GO:0034189; GO:0034447; GO:0030229 calcium ion binding; cholesterol metabolic process; coated pit; extracellular space; glycoprotein transport; glycoprotein transporter activity; integral to membrane; lipid transport; membrane; negative regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite development; positive regulation of protein kinase activity; reelin receptor activity; ventral spinal cord development; very-low-density lipoprotein particle; very-low-density lipoprotein particle binding; very-low-density lipoprotein particle clearance; very-low-density lipoprotein particle receptor activity IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) Vldlr Mus musculus (Mouse) TR43110_c0_g1_i4 Q90596 MAFK_CHICK 3.00E-25 GO:0005634; GO:0043565; GO:0003700; GO:0006351 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; IPR004826; IPR008917; IPR024874; Transcription factor MafK MAFK Gallus gallus (Chicken) TR43113_c0_g1_i1 Q3URJ8 NKAI3_MOUSE 9.00E-35 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR008516; Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3) (Protein FAM77D) Nkain3 Fam77d Mus musculus (Mouse) TR43113_c0_g2_i5 Q9D035 NKAI1_MOUSE 5.00E-13 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR008516; Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 1) (Protein FAM77C) Nkain1 Fam77c Mus musculus (Mouse) TR43113_c0_g2_i7 A6MHQ4 NKAIN_DROME 5.00E-10 GO:0016021; GO:0005886; GO:0002028 integral to membrane; plasma membrane; regulation of sodium ion transport IPR008516; Sodium/potassium-transporting ATPase subunit beta-1-interacting protein (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein) (dNKAIN) NKAIN CG34413 Drosophila melanogaster (Fruit fly) TR43114_c1_g1_i3 O75581 LRP6_HUMAN 1.00E-61 GO:0044332; GO:0021874; GO:0090244; GO:0042813; GO:0034185; GO:0090245; GO:0060349; GO:0046849; GO:0060444; GO:0061310; GO:0044335; GO:0061324; GO:0044340; GO:0042074; GO:0009986; GO:0071397; GO:0021587; GO:0021795; GO:0021987; GO:0060026; GO:0071936; GO:0031410; GO:0071542; GO:0005769; GO:0048596; GO:0042733; GO:0035115; GO:0035116; GO:0030326; GO:0009880; GO:0060059; GO:0005783; GO:0035261; GO:0060325; GO:0021861; GO:0021943; GO:0001947; GO:0016021; GO:0019210; GO:0005041; GO:0060596; GO:0030901; GO:0030917; GO:0050680; GO:0045599; GO:2000151; GO:2000162; GO:2000168; GO:2000164; GO:2000166; GO:2000149; GO:0071901; GO:0034392; GO:0014029; GO:0001843; GO:0043025; GO:0042475; GO:0060021; GO:0003344; GO:0005886; GO:2000055; GO:0043065; GO:0045780; GO:0090263; GO:0045787; GO:0002053; GO:0045778; GO:0051091; GO:0045944; GO:0036342; GO:0090009; GO:0043235; GO:0090118; GO:0060284; GO:0045598; GO:0030278; GO:0051593; GO:0045202; GO:0007268; GO:0021794; GO:0019534; GO:0060535 Q9Y4X0; Q9H6X2; O70239; Q03135; P98082; P49840; P49841; Q5S007; Q9ERE8 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt receptor signaling pathway involved in forebrain neuroblast division; Wnt receptor signaling pathway involved in somitogenesis; Wnt-activated receptor activity; apolipoprotein binding; axis elongation involved in somitogenesis; bone morphogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development; canonical Wnt receptor signaling pathway involved in neural crest cell differentiation; canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; canonical Wnt receptor signaling pathway involved in regulation of cell proliferation; cell migration involved in gastrulation; cell surface; cellular response to cholesterol; cerebellum morphogenesis; cerebral cortex cell migration; cerebral cortex development; convergent extension; coreceptor activity involved in Wnt receptor signaling pathway; cytoplasmic vesicle; dopaminergic neuron differentiation; early endosome; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; embryonic pattern specification; embryonic retina morphogenesis in camera-type eye; endoplasmic reticulum; external genitalia morphogenesis; face morphogenesis; forebrain radial glial cell differentiation; formation of radial glial scaffolds; heart looping; integral to membrane; kinase inhibitor activity; low-density lipoprotein receptor activity; mammary placode formation; midbrain development; midbrain-hindbrain boundary development; negative regulation of epithelial cell proliferation; negative regulation of fat cell differentiation; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis; negative regulation of planar cell polarity pathway involved in neural tube closure; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest formation; neural tube closure; neuronal cell body; odontogenesis of dentin-containing tooth; palate development; pericardium morphogenesis; plasma membrane; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell cycle; positive regulation of mesenchymal cell proliferation; positive regulation of ossification; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; post-anal tail morphogenesis; primitive streak formation; receptor complex; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport; regulation of cell development; regulation of fat cell differentiation; regulation of ossification; response to folic acid; synapse; synaptic transmission; thalamus development; toxin transporter activity; trachea cartilage morphogenesis IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 6 (LRP-6) LRP6 Homo sapiens (Human) TR43114_c1_g2_i1 P10493 NID1_MOUSE 4.00E-76 GO:0005605; GO:0005509; GO:0071944; GO:0007160; GO:0005518; GO:0032836; GO:0043237; GO:0010811 basal lamina; calcium ion binding; cell periphery; cell-matrix adhesion; collagen binding; glomerular basement membrane development; laminin-1 binding; positive regulation of cell-substrate adhesion IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR006605; IPR009017; IPR023413; IPR009030; IPR000033; IPR003886; IPR000716; Nidogen-1 (NID-1) (Entactin) Nid1 Ent Mus musculus (Mouse) TR43115_c1_g2_i1 Q8N2E2 VWDE_HUMAN 1.00E-10 GO:0005576 extracellular region IPR000742; IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) TR43115_c1_g2_i2 Q9W6F8 WIF1_XENLA 2.00E-07 GO:0016055; GO:0005576; GO:0007275 Wnt receptor signaling pathway; extracellular region; multicellular organismal development IPR000742; IPR013032; IPR003306; IPR013309; Wnt inhibitory factor 1 (WIF-1) wif1 Xenopus laevis (African clawed frog) TR43115_c1_g2_i3 P21941 MATN1_HUMAN 1.00E-13 GO:0030198; GO:0005201; GO:0003429; GO:0006461; GO:0005578; GO:0030500 extracellular matrix organization; extracellular matrix structural constituent; growth plate cartilage chondrocyte morphogenesis; protein complex assembly; proteinaceous extracellular matrix; regulation of bone mineralization IPR000742; IPR013032; IPR019466; IPR002035; Cartilage matrix protein (Matrilin-1) MATN1 CMP CRTM Homo sapiens (Human) TR43115_c1_g2_i4 O00339 MATN2_HUMAN 1.00E-10 GO:0007411; GO:0005604; GO:0005509; GO:0031104; GO:0008347; GO:0001764; GO:0005578; GO:0048678 O15265; O00555 axon guidance; basement membrane; calcium ion binding; dendrite regeneration; glial cell migration; neuron migration; proteinaceous extracellular matrix; response to axon injury IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR009030; IPR019466; IPR002035; Matrilin-2 MATN2 UNQ193/PRO219 Homo sapiens (Human) TR43115_c1_g2_i7 P21941 MATN1_HUMAN 2.00E-13 GO:0030198; GO:0005201; GO:0003429; GO:0006461; GO:0005578; GO:0030500 extracellular matrix organization; extracellular matrix structural constituent; growth plate cartilage chondrocyte morphogenesis; protein complex assembly; proteinaceous extracellular matrix; regulation of bone mineralization IPR000742; IPR013032; IPR019466; IPR002035; Cartilage matrix protein (Matrilin-1) MATN1 CMP CRTM Homo sapiens (Human) TR43115_c2_g1_i4 Q8MY85 FGFR2_DUGJA 1.00E-47 GO:0005524; GO:0016021; GO:0018108; GO:0004714 ATP binding; integral to membrane; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity IPR007110; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 2 (DjFgfr2) (FGFR-2) (EC 2.7.10.1) (DjPTK1) FGFR2 Dugesia japonica (Planarian) TR43115_c2_g1_i6 Q0VBZ0 CSK_BOVIN 2.00E-46 GO:0005524; GO:0005794; GO:0005911; GO:0005813; GO:0042997; GO:0008285; GO:0004715; GO:0018108; GO:0005886 ATP binding; Golgi apparatus; cell-cell junction; centrosome; negative regulation of Golgi to plasma membrane protein transport; negative regulation of cell proliferation; non-membrane spanning protein tyrosine kinase activity; peptidyl-tyrosine phosphorylation; plasma membrane IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) CSK Bos taurus (Bovine) TR43115_c2_g1_i7 Q8MY85 FGFR2_DUGJA 1.00E-47 GO:0005524; GO:0016021; GO:0018108; GO:0004714 ATP binding; integral to membrane; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity IPR007110; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 2 (DjFgfr2) (FGFR-2) (EC 2.7.10.1) (DjPTK1) FGFR2 Dugesia japonica (Planarian) TR43118_c0_g1_i11 Q9LT31 VPS9A_ARATH 1.00E-32 GO:0005525; GO:0005096; GO:0005089; GO:0000919; GO:0042546; GO:0005829; GO:0009790; GO:0016020; GO:0005634; GO:0043547; GO:0048528 GTP binding; GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; cell plate assembly; cell wall biogenesis; cytosol; embryo development; membrane; nucleus; positive regulation of GTPase activity; post-embryonic root development IPR003123; IPR013995; Vacuolar protein sorting-associated protein 9A (AtVSP9a) VPS9A VPS9 At3g19770 MMB12.26 Arabidopsis thaliana (Mouse-ear cress) TR43118_c0_g1_i12 Q9UJ41 RABX5_HUMAN 1.00E-102 GO:0003677; GO:0017112; GO:0005769; GO:0006897; GO:0015031; GO:0055037; GO:0008270 P00533; Q9BQD3; P0CG47; P62990 DNA binding; Rab guanyl-nucleotide exchange factor activity; early endosome; endocytosis; protein transport; recycling endosome; zinc ion binding IPR003123; IPR013995; IPR002653; Rab5 GDP/GTP exchange factor (RAP1) (Rabaptin-5-associated exchange factor for Rab5) (Rabex-5) RABGEF1 RABEX5 Homo sapiens (Human) TR43118_c0_g1_i13 Q9JM13 RABX5_MOUSE 9.00E-130 GO:0003677; GO:0005769; GO:0006897; GO:1900235; GO:0046580; GO:0050728; GO:1900165; GO:0002686; GO:0043305; GO:0001933; GO:0048261; GO:0015031; GO:0055037; GO:0060368; GO:0004842; GO:0031982; GO:0008270 DNA binding; early endosome; endocytosis; negative regulation of Kit signaling pathway; negative regulation of Ras protein signal transduction; negative regulation of inflammatory response; negative regulation of interleukin-6 secretion; negative regulation of leukocyte migration; negative regulation of mast cell degranulation; negative regulation of protein phosphorylation; negative regulation of receptor-mediated endocytosis; protein transport; recycling endosome; regulation of Fc receptor mediated stimulatory signaling pathway; ubiquitin-protein ligase activity; vesicle; zinc ion binding IPR003123; IPR013995; IPR002653; Rab5 GDP/GTP exchange factor (Rabex-5) Rabgef1 Rabex5 Mus musculus (Mouse) TR43118_c0_g1_i3 Q9JM13 RABX5_MOUSE 8.00E-134 GO:0003677; GO:0005769; GO:0006897; GO:1900235; GO:0046580; GO:0050728; GO:1900165; GO:0002686; GO:0043305; GO:0001933; GO:0048261; GO:0015031; GO:0055037; GO:0060368; GO:0004842; GO:0031982; GO:0008270 DNA binding; early endosome; endocytosis; negative regulation of Kit signaling pathway; negative regulation of Ras protein signal transduction; negative regulation of inflammatory response; negative regulation of interleukin-6 secretion; negative regulation of leukocyte migration; negative regulation of mast cell degranulation; negative regulation of protein phosphorylation; negative regulation of receptor-mediated endocytosis; protein transport; recycling endosome; regulation of Fc receptor mediated stimulatory signaling pathway; ubiquitin-protein ligase activity; vesicle; zinc ion binding IPR003123; IPR013995; IPR002653; Rab5 GDP/GTP exchange factor (Rabex-5) Rabgef1 Rabex5 Mus musculus (Mouse) TR43118_c0_g1_i7 Q9JM13 RABX5_MOUSE 1.00E-132 GO:0003677; GO:0005769; GO:0006897; GO:1900235; GO:0046580; GO:0050728; GO:1900165; GO:0002686; GO:0043305; GO:0001933; GO:0048261; GO:0015031; GO:0055037; GO:0060368; GO:0004842; GO:0031982; GO:0008270 DNA binding; early endosome; endocytosis; negative regulation of Kit signaling pathway; negative regulation of Ras protein signal transduction; negative regulation of inflammatory response; negative regulation of interleukin-6 secretion; negative regulation of leukocyte migration; negative regulation of mast cell degranulation; negative regulation of protein phosphorylation; negative regulation of receptor-mediated endocytosis; protein transport; recycling endosome; regulation of Fc receptor mediated stimulatory signaling pathway; ubiquitin-protein ligase activity; vesicle; zinc ion binding IPR003123; IPR013995; IPR002653; Rab5 GDP/GTP exchange factor (Rabex-5) Rabgef1 Rabex5 Mus musculus (Mouse) TR43118_c0_g1_i8 Q9UJ41 RABX5_HUMAN 2.00E-102 GO:0003677; GO:0017112; GO:0005769; GO:0006897; GO:0015031; GO:0055037; GO:0008270 P00533; Q9BQD3; P0CG47; P62990 DNA binding; Rab guanyl-nucleotide exchange factor activity; early endosome; endocytosis; protein transport; recycling endosome; zinc ion binding IPR003123; IPR013995; IPR002653; Rab5 GDP/GTP exchange factor (RAP1) (Rabaptin-5-associated exchange factor for Rab5) (Rabex-5) RABGEF1 RABEX5 Homo sapiens (Human) TR43118_c0_g1_i9 Q9JM13 RABX5_MOUSE 7.00E-134 GO:0003677; GO:0005769; GO:0006897; GO:1900235; GO:0046580; GO:0050728; GO:1900165; GO:0002686; GO:0043305; GO:0001933; GO:0048261; GO:0015031; GO:0055037; GO:0060368; GO:0004842; GO:0031982; GO:0008270 DNA binding; early endosome; endocytosis; negative regulation of Kit signaling pathway; negative regulation of Ras protein signal transduction; negative regulation of inflammatory response; negative regulation of interleukin-6 secretion; negative regulation of leukocyte migration; negative regulation of mast cell degranulation; negative regulation of protein phosphorylation; negative regulation of receptor-mediated endocytosis; protein transport; recycling endosome; regulation of Fc receptor mediated stimulatory signaling pathway; ubiquitin-protein ligase activity; vesicle; zinc ion binding IPR003123; IPR013995; IPR002653; Rab5 GDP/GTP exchange factor (Rabex-5) Rabgef1 Rabex5 Mus musculus (Mouse) TR43121_c8_g5_i1 P97793 ALK_MOUSE 7.00E-12 GO:0005524; GO:0000187; GO:0005887; GO:0048666; GO:0004714; GO:0007169 ATP binding; activation of MAPK activity; integral to plasma membrane; neuron development; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR026830; IPR008985; IPR011009; IPR002172; IPR000998; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR002011; ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) Alk Mus musculus (Mouse) TR43121_c8_g5_i2 Q5VYJ5 CJ112_HUMAN 2.00E-07 GO:0016021 integral to membrane IPR008985; IPR023415; IPR002172; IPR000998; MAM and LDL-receptor class A domain-containing protein C10orf112 C10orf112 Homo sapiens (Human) TR43122_c2_g2_i1 Q58EX7 PKHG4_HUMAN 3.00E-123 GO:0005089; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; phospholipid binding; regulation of Rho protein signal transduction IPR001251; IPR000219; IPR011993; IPR001849; Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1) PLEKHG4 PRTPHN1 Homo sapiens (Human) TR43123_c0_g2_i2 Q29RK2 PYC_BOVIN 1.00E-46 GO:0005524; GO:0003677; GO:0004075; GO:0006094; GO:0006629; GO:0046872; GO:0005743; GO:0005759; GO:0004736 ATP binding; DNA binding; biotin carboxylase activity; gluconeogenesis; lipid metabolic process; metal ion binding; mitochondrial inner membrane; mitochondrial matrix; pyruvate carboxylase activity IPR013785; IPR011761; IPR013815; IPR013816; IPR001882; IPR011764; IPR005482; IPR000089; IPR005481; IPR003379; IPR005479; IPR009057; IPR016185; IPR000891; IPR005930; IPR011054; IPR011053; Carbohydrate biosynthesis; gluconeogenesis. "Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)" PC Bos taurus (Bovine) TR43123_c0_g2_i3 P11029 ACAC_CHICK 0 GO:0005524; GO:0003989; GO:0004075; GO:0005737; GO:0006633; GO:2001295; GO:0046872 ATP binding; acetyl-CoA carboxylase activity; biotin carboxylase activity; cytoplasm; fatty acid biosynthetic process; malonyl-CoA biosynthetic process; metal ion binding IPR013537; IPR011761; IPR013815; IPR013816; IPR001882; IPR011764; IPR005482; IPR000089; IPR005481; IPR000022; IPR005479; IPR011763; IPR011762; IPR016185; IPR011054; IPR011053; Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase (ACC) (EC 6.4.1.2) [Includes: Biotin carboxylase (EC 6.3.4.14)] ACAC Gallus gallus (Chicken) TR43123_c0_g2_i5 P11029 ACAC_CHICK 2.00E-56 GO:0005524; GO:0003989; GO:0004075; GO:0005737; GO:0006633; GO:2001295; GO:0046872 ATP binding; acetyl-CoA carboxylase activity; biotin carboxylase activity; cytoplasm; fatty acid biosynthetic process; malonyl-CoA biosynthetic process; metal ion binding IPR013537; IPR011761; IPR013815; IPR013816; IPR001882; IPR011764; IPR005482; IPR000089; IPR005481; IPR000022; IPR005479; IPR011763; IPR011762; IPR016185; IPR011054; IPR011053; Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase (ACC) (EC 6.4.1.2) [Includes: Biotin carboxylase (EC 6.3.4.14)] ACAC Gallus gallus (Chicken) TR43124_c0_g2_i1 P48738 PIPNA_RABIT 1.00E-110 GO:0005737; GO:0008289; GO:0006810 cytoplasm; lipid binding; transport IPR001666; IPR023393; Phosphatidylinositol transfer protein alpha isoform (PI-TP-alpha) (PtdIns transfer protein alpha) (PtdInsTP alpha) PITPNA PITPN Oryctolagus cuniculus (Rabbit) TR43125_c1_g4_i1 Q969M7 UBE2F_HUMAN 5.00E-76 GO:0005524; GO:0019788; GO:0045116 ATP binding; NEDD8 ligase activity; protein neddylation IPR000608; IPR023313; IPR016135; Protein modification; protein neddylation. NEDD8-conjugating enzyme UBE2F (EC 6.3.2.-) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8-conjugating enzyme 2) (Ubiquitin-conjugating enzyme E2 F) UBE2F NCE2 Homo sapiens (Human) TR43125_c1_g4_i3 Q969M7 UBE2F_HUMAN 4.00E-77 GO:0005524; GO:0019788; GO:0045116 ATP binding; NEDD8 ligase activity; protein neddylation IPR000608; IPR023313; IPR016135; Protein modification; protein neddylation. NEDD8-conjugating enzyme UBE2F (EC 6.3.2.-) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8-conjugating enzyme 2) (Ubiquitin-conjugating enzyme E2 F) UBE2F NCE2 Homo sapiens (Human) TR43126_c0_g1_i1 P21872 PUR2_CHICK 1.00E-166 GO:0006189; GO:0005524; GO:0005829; GO:0046872; GO:0032259; GO:0008168; GO:0004637; GO:0004641; GO:0004644; GO:0009113; GO:0006144 'de novo' IMP biosynthetic process; ATP binding; cytosol; metal ion binding; methylation; methyltransferase activity; phosphoribosylamine-glycine ligase activity; phosphoribosylformylglycinamidine cyclo-ligase activity; phosphoribosylglycinamide formyltransferase activity; purine nucleobase biosynthetic process; purine nucleobase metabolic process IPR010918; IPR000728; IPR011761; IPR013815; IPR013816; IPR002376; IPR001555; IPR016185; IPR020561; IPR000115; IPR020560; IPR020559; IPR020562; IPR004733; IPR016188; IPR004607; IPR011054; Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1. Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] GART Gallus gallus (Chicken) TR43126_c1_g1_i1 Q59A32 PUR2_BOVIN 4.00E-165 GO:0006189; GO:0005524; GO:0005737; GO:0046872; GO:0032259; GO:0008168; GO:0004637; GO:0004641; GO:0004644; GO:0009113 'de novo' IMP biosynthetic process; ATP binding; cytoplasm; metal ion binding; methylation; methyltransferase activity; phosphoribosylamine-glycine ligase activity; phosphoribosylformylglycinamidine cyclo-ligase activity; phosphoribosylglycinamide formyltransferase activity; purine nucleobase biosynthetic process IPR010918; IPR000728; IPR011761; IPR013815; IPR013816; IPR002376; IPR001555; IPR016185; IPR020561; IPR000115; IPR020560; IPR020559; IPR020562; IPR004733; IPR016188; IPR004607; IPR011054; Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1. Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] GART Bos taurus (Bovine) TR43126_c1_g1_i2 B8IP71 PUR5_METNO 3.00E-132 GO:0006189; GO:0005524; GO:0005737; GO:0004641 'de novo' IMP biosynthetic process; ATP binding; cytoplasm; phosphoribosylformylglycinamidine cyclo-ligase activity IPR010918; IPR000728; IPR004733; IPR016188; Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) purM Mnod_5547 Methylobacterium nodulans (strain ORS2060 / LMG 21967) TR43126_c2_g1_i1 P43846 PUR3_HAEIN 5.00E-27 GO:0006189; GO:0032259; GO:0008168; GO:0004644 'de novo' IMP biosynthetic process; methylation; methyltransferase activity; phosphoribosylglycinamide formyltransferase activity IPR002376; IPR001555; IPR004607; Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1. Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART) purN HI_1428 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) TR43127_c2_g1_i1 F1M386 RPGF2_RAT 2.00E-139 GO:0005096; GO:0030165; GO:0017034; GO:0032486; GO:0050699; GO:0071880; GO:0031697; GO:0001568; GO:0031547; GO:0030552; GO:0019933; GO:0005911; GO:0071320; GO:0071321; GO:0061028; GO:0021884; GO:0005770; GO:0008285; GO:0050774; GO:0048022; GO:0038180; GO:0001764; GO:0043005; GO:0031175; GO:0043025; GO:0007218; GO:0048471; GO:0005886; GO:0070374; GO:0032854; GO:2000481; GO:0043950; GO:2000670; GO:2001224; GO:0010976; GO:0032092; GO:2001214; GO:0043234; GO:1901888; GO:0048167; GO:0045202; GO:0021591 GTPase activator activity; PDZ domain binding; Rap guanyl-nucleotide exchange factor activity; Rap protein signal transduction; WW domain binding; adenylate cyclase-activating adrenergic receptor signaling pathway; beta-1 adrenergic receptor binding; blood vessel development; brain-derived neurotrophic factor receptor signaling pathway; cAMP binding; cAMP-mediated signaling; cell-cell junction; cellular response to cAMP; cellular response to cGMP; establishment of endothelial barrier; forebrain neuron development; late endosome; negative regulation of cell proliferation; negative regulation of dendrite morphogenesis; negative regulation of melanin biosynthetic process; nerve growth factor signaling pathway; neuron migration; neuron projection; neuron projection development; neuronal cell body; neuropeptide signaling pathway; perinuclear region of cytoplasm; plasma membrane; positive regulation of ERK1 and ERK2 cascade; positive regulation of Rap GTPase activity; positive regulation of cAMP-dependent protein kinase activity; positive regulation of cAMP-mediated signaling; positive regulation of dendritic cell apoptotic process; positive regulation of neuron migration; positive regulation of neuron projection development; positive regulation of protein binding; positive regulation of vasculogenesis; protein complex; regulation of cell junction assembly; regulation of synaptic plasticity; synapse; ventricular system development IPR018490; IPR000595; IPR001478; IPR000159; IPR000651; IPR008937; IPR023578; IPR001895; IPR014710; Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) Rapgef2 Pdzgef1 Rattus norvegicus (Rat) TR43127_c2_g1_i2 F1M386 RPGF2_RAT 1.00E-140 GO:0005096; GO:0030165; GO:0017034; GO:0032486; GO:0050699; GO:0071880; GO:0031697; GO:0001568; GO:0031547; GO:0030552; GO:0019933; GO:0005911; GO:0071320; GO:0071321; GO:0061028; GO:0021884; GO:0005770; GO:0008285; GO:0050774; GO:0048022; GO:0038180; GO:0001764; GO:0043005; GO:0031175; GO:0043025; GO:0007218; GO:0048471; GO:0005886; GO:0070374; GO:0032854; GO:2000481; GO:0043950; GO:2000670; GO:2001224; GO:0010976; GO:0032092; GO:2001214; GO:0043234; GO:1901888; GO:0048167; GO:0045202; GO:0021591 GTPase activator activity; PDZ domain binding; Rap guanyl-nucleotide exchange factor activity; Rap protein signal transduction; WW domain binding; adenylate cyclase-activating adrenergic receptor signaling pathway; beta-1 adrenergic receptor binding; blood vessel development; brain-derived neurotrophic factor receptor signaling pathway; cAMP binding; cAMP-mediated signaling; cell-cell junction; cellular response to cAMP; cellular response to cGMP; establishment of endothelial barrier; forebrain neuron development; late endosome; negative regulation of cell proliferation; negative regulation of dendrite morphogenesis; negative regulation of melanin biosynthetic process; nerve growth factor signaling pathway; neuron migration; neuron projection; neuron projection development; neuronal cell body; neuropeptide signaling pathway; perinuclear region of cytoplasm; plasma membrane; positive regulation of ERK1 and ERK2 cascade; positive regulation of Rap GTPase activity; positive regulation of cAMP-dependent protein kinase activity; positive regulation of cAMP-mediated signaling; positive regulation of dendritic cell apoptotic process; positive regulation of neuron migration; positive regulation of neuron projection development; positive regulation of protein binding; positive regulation of vasculogenesis; protein complex; regulation of cell junction assembly; regulation of synaptic plasticity; synapse; ventricular system development IPR018490; IPR000595; IPR001478; IPR000159; IPR000651; IPR008937; IPR023578; IPR001895; IPR014710; Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) Rapgef2 Pdzgef1 Rattus norvegicus (Rat) TR43127_c2_g1_i3 Q8WZA2 RPGF4_HUMAN 4.00E-44 GO:0007186; GO:0017016; GO:0005088; GO:0030552; GO:0005952; GO:0008603; GO:0019933; GO:0017156; GO:0005829; GO:0006112; GO:0030073; GO:0005886; GO:0030168; GO:0017157; GO:0050796; GO:0051056; GO:0007264; GO:0044281 G-protein coupled receptor signaling pathway; Ras GTPase binding; Ras guanyl-nucleotide exchange factor activity; cAMP binding; cAMP-dependent protein kinase complex; cAMP-dependent protein kinase regulator activity; cAMP-mediated signaling; calcium ion-dependent exocytosis; cytosol; energy reserve metabolic process; insulin secretion; plasma membrane; platelet activation; regulation of exocytosis; regulation of insulin secretion; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; small molecule metabolic process IPR002373; IPR018490; IPR000595; IPR000591; IPR000159; IPR000651; IPR019804; IPR008937; IPR023578; IPR001895; IPR014710; IPR011991; Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) RAPGEF4 CGEF2 EPAC2 Homo sapiens (Human) TR43127_c2_g1_i4 Q02342 CDC25_LACKL 5.00E-22 GO:0051301; GO:0005085; GO:0016021; GO:0005622; GO:0007067; GO:0051056; GO:0007264 cell division; guanyl-nucleotide exchange factor activity; integral to membrane; intracellular; mitosis; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR000651; IPR019804; IPR008937; IPR023578; IPR001895; Cell division control protein 25 (Fragment) CDC25 Lachancea kluyveri (Yeast) (Saccharomyces kluyveri) TR43127_c2_g1_i5 F1M386 RPGF2_RAT 3.00E-139 GO:0005096; GO:0030165; GO:0017034; GO:0032486; GO:0050699; GO:0071880; GO:0031697; GO:0001568; GO:0031547; GO:0030552; GO:0019933; GO:0005911; GO:0071320; GO:0071321; GO:0061028; GO:0021884; GO:0005770; GO:0008285; GO:0050774; GO:0048022; GO:0038180; GO:0001764; GO:0043005; GO:0031175; GO:0043025; GO:0007218; GO:0048471; GO:0005886; GO:0070374; GO:0032854; GO:2000481; GO:0043950; GO:2000670; GO:2001224; GO:0010976; GO:0032092; GO:2001214; GO:0043234; GO:1901888; GO:0048167; GO:0045202; GO:0021591 GTPase activator activity; PDZ domain binding; Rap guanyl-nucleotide exchange factor activity; Rap protein signal transduction; WW domain binding; adenylate cyclase-activating adrenergic receptor signaling pathway; beta-1 adrenergic receptor binding; blood vessel development; brain-derived neurotrophic factor receptor signaling pathway; cAMP binding; cAMP-mediated signaling; cell-cell junction; cellular response to cAMP; cellular response to cGMP; establishment of endothelial barrier; forebrain neuron development; late endosome; negative regulation of cell proliferation; negative regulation of dendrite morphogenesis; negative regulation of melanin biosynthetic process; nerve growth factor signaling pathway; neuron migration; neuron projection; neuron projection development; neuronal cell body; neuropeptide signaling pathway; perinuclear region of cytoplasm; plasma membrane; positive regulation of ERK1 and ERK2 cascade; positive regulation of Rap GTPase activity; positive regulation of cAMP-dependent protein kinase activity; positive regulation of cAMP-mediated signaling; positive regulation of dendritic cell apoptotic process; positive regulation of neuron migration; positive regulation of neuron projection development; positive regulation of protein binding; positive regulation of vasculogenesis; protein complex; regulation of cell junction assembly; regulation of synaptic plasticity; synapse; ventricular system development IPR018490; IPR000595; IPR001478; IPR000159; IPR000651; IPR008937; IPR023578; IPR001895; IPR014710; Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) Rapgef2 Pdzgef1 Rattus norvegicus (Rat) TR43127_c2_g1_i6 Q8WZA2 RPGF4_HUMAN 1.00E-43 GO:0007186; GO:0017016; GO:0005088; GO:0030552; GO:0005952; GO:0008603; GO:0019933; GO:0017156; GO:0005829; GO:0006112; GO:0030073; GO:0005886; GO:0030168; GO:0017157; GO:0050796; GO:0051056; GO:0007264; GO:0044281 G-protein coupled receptor signaling pathway; Ras GTPase binding; Ras guanyl-nucleotide exchange factor activity; cAMP binding; cAMP-dependent protein kinase complex; cAMP-dependent protein kinase regulator activity; cAMP-mediated signaling; calcium ion-dependent exocytosis; cytosol; energy reserve metabolic process; insulin secretion; plasma membrane; platelet activation; regulation of exocytosis; regulation of insulin secretion; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; small molecule metabolic process IPR002373; IPR018490; IPR000595; IPR000591; IPR000159; IPR000651; IPR019804; IPR008937; IPR023578; IPR001895; IPR014710; IPR011991; Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) RAPGEF4 CGEF2 EPAC2 Homo sapiens (Human) TR43127_c2_g1_i7 Q02342 CDC25_LACKL 5.00E-22 GO:0051301; GO:0005085; GO:0016021; GO:0005622; GO:0007067; GO:0051056; GO:0007264 cell division; guanyl-nucleotide exchange factor activity; integral to membrane; intracellular; mitosis; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR000651; IPR019804; IPR008937; IPR023578; IPR001895; Cell division control protein 25 (Fragment) CDC25 Lachancea kluyveri (Yeast) (Saccharomyces kluyveri) TR43127_c2_g1_i8 Q02342 CDC25_LACKL 4.00E-22 GO:0051301; GO:0005085; GO:0016021; GO:0005622; GO:0007067; GO:0051056; GO:0007264 cell division; guanyl-nucleotide exchange factor activity; integral to membrane; intracellular; mitosis; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR000651; IPR019804; IPR008937; IPR023578; IPR001895; Cell division control protein 25 (Fragment) CDC25 Lachancea kluyveri (Yeast) (Saccharomyces kluyveri) TR43127_c2_g1_i9 F1M386 RPGF2_RAT 2.00E-140 GO:0005096; GO:0030165; GO:0017034; GO:0032486; GO:0050699; GO:0071880; GO:0031697; GO:0001568; GO:0031547; GO:0030552; GO:0019933; GO:0005911; GO:0071320; GO:0071321; GO:0061028; GO:0021884; GO:0005770; GO:0008285; GO:0050774; GO:0048022; GO:0038180; GO:0001764; GO:0043005; GO:0031175; GO:0043025; GO:0007218; GO:0048471; GO:0005886; GO:0070374; GO:0032854; GO:2000481; GO:0043950; GO:2000670; GO:2001224; GO:0010976; GO:0032092; GO:2001214; GO:0043234; GO:1901888; GO:0048167; GO:0045202; GO:0021591 GTPase activator activity; PDZ domain binding; Rap guanyl-nucleotide exchange factor activity; Rap protein signal transduction; WW domain binding; adenylate cyclase-activating adrenergic receptor signaling pathway; beta-1 adrenergic receptor binding; blood vessel development; brain-derived neurotrophic factor receptor signaling pathway; cAMP binding; cAMP-mediated signaling; cell-cell junction; cellular response to cAMP; cellular response to cGMP; establishment of endothelial barrier; forebrain neuron development; late endosome; negative regulation of cell proliferation; negative regulation of dendrite morphogenesis; negative regulation of melanin biosynthetic process; nerve growth factor signaling pathway; neuron migration; neuron projection; neuron projection development; neuronal cell body; neuropeptide signaling pathway; perinuclear region of cytoplasm; plasma membrane; positive regulation of ERK1 and ERK2 cascade; positive regulation of Rap GTPase activity; positive regulation of cAMP-dependent protein kinase activity; positive regulation of cAMP-mediated signaling; positive regulation of dendritic cell apoptotic process; positive regulation of neuron migration; positive regulation of neuron projection development; positive regulation of protein binding; positive regulation of vasculogenesis; protein complex; regulation of cell junction assembly; regulation of synaptic plasticity; synapse; ventricular system development IPR018490; IPR000595; IPR001478; IPR000159; IPR000651; IPR008937; IPR023578; IPR001895; IPR014710; Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) Rapgef2 Pdzgef1 Rattus norvegicus (Rat) TR43128_c0_g1_i1 Q92673 SORL_HUMAN 5.00E-06 GO:0005794; GO:0008219; GO:0008203; GO:0005768; GO:0005615; GO:0005887; GO:0006869; GO:0034362; GO:0030169; GO:0006605; GO:0006898; GO:0014910; GO:0004888 Golgi apparatus; cell death; cholesterol metabolic process; endosome; extracellular space; integral to plasma membrane; lipid transport; low-density lipoprotein particle; low-density lipoprotein particle binding; protein targeting; receptor-mediated endocytosis; regulation of smooth muscle cell migration; transmembrane signaling receptor activity IPR011042; IPR000742; IPR003961; IPR013783; IPR023415; IPR000033; IPR002172; IPR006581; Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) SORL1 C11orf32 Homo sapiens (Human) TR43128_c0_g3_i1 P56677 ST14_MOUSE 8.00E-21 GO:0016477; GO:0005576; GO:0019897; GO:0005887; GO:0006508; GO:0004252; GO:0008236 cell migration; extracellular region; extrinsic to plasma membrane; integral to plasma membrane; proteolysis; serine-type endopeptidase activity; serine-type peptidase activity IPR000859; IPR023415; IPR002172; IPR001254; IPR018114; IPR017051; IPR000082; IPR009003; Suppressor of tumorigenicity 14 protein homolog (EC 3.4.21.109) (Epithin) (Serine protease 14) St14 Prss14 Mus musculus (Mouse) TR43128_c0_g3_i10 Q92673 SORL_HUMAN 6.00E-93 GO:0005794; GO:0008219; GO:0008203; GO:0005768; GO:0005615; GO:0005887; GO:0006869; GO:0034362; GO:0030169; GO:0006605; GO:0006898; GO:0014910; GO:0004888 Golgi apparatus; cell death; cholesterol metabolic process; endosome; extracellular space; integral to plasma membrane; lipid transport; low-density lipoprotein particle; low-density lipoprotein particle binding; protein targeting; receptor-mediated endocytosis; regulation of smooth muscle cell migration; transmembrane signaling receptor activity IPR011042; IPR000742; IPR003961; IPR013783; IPR023415; IPR000033; IPR002172; IPR006581; Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) SORL1 C11orf32 Homo sapiens (Human) TR43128_c0_g3_i2 P70211 DCC_MOUSE 3.00E-09 GO:0033564; GO:0006915; GO:0030424; GO:0033563; GO:0016021; GO:0001764; GO:0005886; GO:0021965 Q9ERC8; P56270; P56671 anterior/posterior axon guidance; apoptotic process; axon; dorsal/ventral axon guidance; integral to membrane; neuron migration; plasma membrane; spinal cord ventral commissure morphogenesis IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR010560; Netrin receptor DCC (Tumor suppressor protein DCC) Dcc Mus musculus (Mouse) TR43128_c0_g3_i3 Q92673 SORL_HUMAN 4.00E-98 GO:0005794; GO:0008219; GO:0008203; GO:0005768; GO:0005615; GO:0005887; GO:0006869; GO:0034362; GO:0030169; GO:0006605; GO:0006898; GO:0014910; GO:0004888 Golgi apparatus; cell death; cholesterol metabolic process; endosome; extracellular space; integral to plasma membrane; lipid transport; low-density lipoprotein particle; low-density lipoprotein particle binding; protein targeting; receptor-mediated endocytosis; regulation of smooth muscle cell migration; transmembrane signaling receptor activity IPR011042; IPR000742; IPR003961; IPR013783; IPR023415; IPR000033; IPR002172; IPR006581; Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) SORL1 C11orf32 Homo sapiens (Human) TR43128_c0_g3_i4 O88307 SORL_MOUSE 2.00E-98 GO:0005794; GO:0008203; GO:0006897; GO:0005768; GO:0016021; GO:0006869; GO:0034362; GO:0030169; GO:0007275; GO:0048471 Golgi apparatus; cholesterol metabolic process; endocytosis; endosome; integral to membrane; lipid transport; low-density lipoprotein particle; low-density lipoprotein particle binding; multicellular organismal development; perinuclear region of cytoplasm IPR011042; IPR003961; IPR013783; IPR023415; IPR000033; IPR002172; IPR006581; Sortilin-related receptor (Gp250) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) Sorl1 Mus musculus (Mouse) TR43128_c0_g3_i5 A4IFW2 PTPRF_DANRE 2.00E-17 GO:0007155; GO:0008201; GO:0016021; GO:0035335; GO:0004725; GO:0097374 cell adhesion; heparin binding; integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; sensory neuron axon guidance IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) ptprf si:dkey-21k10.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR43128_c0_g3_i6 Q92673 SORL_HUMAN 3.00E-95 GO:0005794; GO:0008219; GO:0008203; GO:0005768; GO:0005615; GO:0005887; GO:0006869; GO:0034362; GO:0030169; GO:0006605; GO:0006898; GO:0014910; GO:0004888 Golgi apparatus; cell death; cholesterol metabolic process; endosome; extracellular space; integral to plasma membrane; lipid transport; low-density lipoprotein particle; low-density lipoprotein particle binding; protein targeting; receptor-mediated endocytosis; regulation of smooth muscle cell migration; transmembrane signaling receptor activity IPR011042; IPR000742; IPR003961; IPR013783; IPR023415; IPR000033; IPR002172; IPR006581; Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) SORL1 C11orf32 Homo sapiens (Human) TR43128_c0_g3_i7 Q92673 SORL_HUMAN 4.00E-98 GO:0005794; GO:0008219; GO:0008203; GO:0005768; GO:0005615; GO:0005887; GO:0006869; GO:0034362; GO:0030169; GO:0006605; GO:0006898; GO:0014910; GO:0004888 Golgi apparatus; cell death; cholesterol metabolic process; endosome; extracellular space; integral to plasma membrane; lipid transport; low-density lipoprotein particle; low-density lipoprotein particle binding; protein targeting; receptor-mediated endocytosis; regulation of smooth muscle cell migration; transmembrane signaling receptor activity IPR011042; IPR000742; IPR003961; IPR013783; IPR023415; IPR000033; IPR002172; IPR006581; Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) SORL1 C11orf32 Homo sapiens (Human) TR43128_c0_g3_i8 P20063 LDLR_RABIT 5.00E-39 GO:0005794; GO:0005509; GO:0009986; GO:0008203; GO:0005905; GO:0005769; GO:0006897; GO:0016021; GO:0005770; GO:0006869; GO:0034362; GO:0005764; GO:0005886 Golgi apparatus; calcium ion binding; cell surface; cholesterol metabolic process; coated pit; early endosome; endocytosis; integral to membrane; late endosome; lipid transport; low-density lipoprotein particle; lysosome; plasma membrane IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor (LDL receptor) (Fragment) LDLR Oryctolagus cuniculus (Rabbit) TR43128_c0_g3_i9 O88307 SORL_MOUSE 2.00E-98 GO:0005794; GO:0008203; GO:0006897; GO:0005768; GO:0016021; GO:0006869; GO:0034362; GO:0030169; GO:0007275; GO:0048471 Golgi apparatus; cholesterol metabolic process; endocytosis; endosome; integral to membrane; lipid transport; low-density lipoprotein particle; low-density lipoprotein particle binding; multicellular organismal development; perinuclear region of cytoplasm IPR011042; IPR003961; IPR013783; IPR023415; IPR000033; IPR002172; IPR006581; Sortilin-related receptor (Gp250) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) Sorl1 Mus musculus (Mouse) TR43128_c0_g4_i1 Q98930 SORL_CHICK 0 GO:0008203; GO:0006897; GO:0016021; GO:0006869; GO:0034362 cholesterol metabolic process; endocytosis; integral to membrane; lipid transport; low-density lipoprotein particle IPR011042; IPR003961; IPR013783; IPR023415; IPR000033; IPR002172; IPR006581; Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (Fragment) SORL1 Gallus gallus (Chicken) TR43130_c5_g1_i2 Q3BAI2 YCX91_PHAAO 6.00E-15 GO:0009507 chloroplast Uncharacterized protein ORF91 Phalaenopsis aphrodite subsp. formosana (Moth orchid) TR43133_c1_g1_i1 Q9U943 APLP_LOCMI 3.00E-60 GO:0016055; GO:0005576; GO:0008289; GO:0005319 Wnt receptor signaling pathway; extracellular region; lipid binding; lipid transporter activity IPR015819; IPR001747; IPR009454; IPR015816; IPR015255; IPR015817; IPR015818; IPR011030; IPR001846; Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)] Locusta migratoria (Migratory locust) TR43133_c1_g1_i2 Q9U943 APLP_LOCMI 3.00E-60 GO:0016055; GO:0005576; GO:0008289; GO:0005319 Wnt receptor signaling pathway; extracellular region; lipid binding; lipid transporter activity IPR015819; IPR001747; IPR009454; IPR015816; IPR015255; IPR015817; IPR015818; IPR011030; IPR001846; Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)] Locusta migratoria (Migratory locust) TR43135_c0_g1_i1 O94875 SRBS2_HUMAN 3.00E-36 GO:0030018; GO:0015629; GO:0008093; GO:0046872; GO:0005634; GO:0048471; GO:0005886; GO:0005200; GO:0008307 Q13177; Q8WX93; P63104 Z disc; actin cytoskeleton; cytoskeletal adaptor activity; metal ion binding; nucleus; perinuclear region of cytoplasm; plasma membrane; structural constituent of cytoskeleton; structural constituent of muscle IPR000108; IPR001452; IPR003127; IPR007087; Sorbin and SH3 domain-containing protein 2 (Arg/Abl-interacting protein 2) (ArgBP2) (Sorbin) SORBS2 ARGBP2 KIAA0777 Homo sapiens (Human) TR43135_c0_g1_i2 Q62417 SRBS1_MOUSE 4.00E-32 GO:0005913; GO:0005924; GO:0005829; GO:0005925; GO:0048041; GO:0015758; GO:0005158; GO:0008286; GO:0045121; GO:0016363; GO:0005886; GO:0090004; GO:0046326; GO:0045725; GO:0046889; GO:0019901; GO:0001725; GO:0043149 P49023; P18206 cell-cell adherens junction; cell-substrate adherens junction; cytosol; focal adhesion; focal adhesion assembly; glucose transport; insulin receptor binding; insulin receptor signaling pathway; membrane raft; nuclear matrix; plasma membrane; positive regulation of establishment of protein localization to plasma membrane; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of lipid biosynthetic process; protein kinase binding; stress fiber; stress fiber assembly IPR000108; IPR011511; IPR001452; IPR003127; Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) Sorbs1 Kiaa1296 Sh3d5 Mus musculus (Mouse) TR43135_c0_g1_i4 O94875 SRBS2_HUMAN 3.00E-36 GO:0030018; GO:0015629; GO:0008093; GO:0046872; GO:0005634; GO:0048471; GO:0005886; GO:0005200; GO:0008307 Q13177; Q8WX93; P63104 Z disc; actin cytoskeleton; cytoskeletal adaptor activity; metal ion binding; nucleus; perinuclear region of cytoplasm; plasma membrane; structural constituent of cytoskeleton; structural constituent of muscle IPR000108; IPR001452; IPR003127; IPR007087; Sorbin and SH3 domain-containing protein 2 (Arg/Abl-interacting protein 2) (ArgBP2) (Sorbin) SORBS2 ARGBP2 KIAA0777 Homo sapiens (Human) TR43135_c0_g1_i5 O94875 SRBS2_HUMAN 3.00E-36 GO:0030018; GO:0015629; GO:0008093; GO:0046872; GO:0005634; GO:0048471; GO:0005886; GO:0005200; GO:0008307 Q13177; Q8WX93; P63104 Z disc; actin cytoskeleton; cytoskeletal adaptor activity; metal ion binding; nucleus; perinuclear region of cytoplasm; plasma membrane; structural constituent of cytoskeleton; structural constituent of muscle IPR000108; IPR001452; IPR003127; IPR007087; Sorbin and SH3 domain-containing protein 2 (Arg/Abl-interacting protein 2) (ArgBP2) (Sorbin) SORBS2 ARGBP2 KIAA0777 Homo sapiens (Human) TR43136_c0_g1_i2 Q5ZQU0 SNED1_RAT 3.00E-06 GO:0005509; GO:0007160; GO:0005576 calcium ion binding; cell-matrix adhesion; extracellular region IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003961; IPR009030; IPR013783; IPR003886; IPR000436; "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" Sned1 Rattus norvegicus (Rat) TR43136_c0_g1_i3 P32018 COEA1_CHICK 1.00E-07 GO:0007155; GO:0005581 cell adhesion; collagen IPR008160; IPR008985; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XIV) chain (Undulin) COL14A1 Gallus gallus (Chicken) TR43136_c0_g2_i1 Q8WZ42 TITIN_HUMAN 2.00E-72 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR43136_c0_g2_i2 Q02173 MPSF_CHICK 3.00E-50 IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; "M-protein, striated muscle" Gallus gallus (Chicken) TR43136_c0_g2_i3 Q6AZB0 BOC_MOUSE 5.00E-11 GO:0030424; GO:0007411; GO:0009986; GO:0016337; GO:0030426; GO:0005887; GO:0043025; GO:0045663; GO:0007224 axon; axon guidance; cell surface; cell-cell adhesion; growth cone; integral to plasma membrane; neuronal cell body; positive regulation of myoblast differentiation; smoothened signaling pathway IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Brother of CDO (Protein BOC) Boc Mus musculus (Mouse) TR43136_c0_g2_i4 Q90688 MYPC3_CHICK 6.00E-28 GO:0001671; GO:0007155; GO:0032982; GO:0032971 ATPase activator activity; cell adhesion; myosin filament; regulation of muscle filament sliding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; "Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)" MYBPC3 Gallus gallus (Chicken) TR43136_c1_g2_i1 Q23551 UNC22_CAEEL 1.00E-100 GO:0031672; GO:0005524; GO:0046872; GO:0004674 A band; ATP binding; metal ion binding; protein serine/threonine kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans TR43136_c1_g2_i2 O35136 NCAM2_MOUSE 4.00E-10 GO:0031225; GO:0030424; GO:0007155; GO:0016021; GO:0005886 anchored to membrane; axon; cell adhesion; integral to membrane; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR009138; Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2) (Neural cell adhesion molecule RB-8) (R4B12) Ncam2 Ocam Rncam Mus musculus (Mouse) TR43138_c0_g4_i1 A4IIJ3 KIBRA_XENTR 9.00E-10 GO:0005737; GO:0005634; GO:0006355; GO:0006351 "cytoplasm; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000008; IPR009449; IPR001202; Protein KIBRA (WW domain-containing protein 1) wwc1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR43138_c0_g4_i2 Q2EJA0 YAP1_RAT 9.00E-56 GO:0006975; GO:0071480; GO:0005737; GO:0005634; GO:0006355; GO:0044212; GO:0006351 "DNA damage induced protein phosphorylation; cellular response to gamma radiation; cytoplasm; nucleus; regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; transcription, DNA-dependent" IPR001202; Yorkie homolog (65 kDa Yes-associated protein) (YAP65) Yap1 Yap Yap65 Rattus norvegicus (Rat) TR43139_c0_g1_i2 Q965W1 FABP9_CAEEL 2.00E-10 GO:0008289; GO:0005215 lipid binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; Fatty acid-binding protein homolog 9 lbp-9 Y40B10A.1 Caenorhabditis elegans TR43139_c1_g1_i2 Q5G267 NETR_MACMU 4.00E-134 GO:0030424; GO:0006887; GO:0005576; GO:0005886; GO:0006508; GO:0005044; GO:0004252 axon; exocytosis; extracellular region; plasma membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR001190; IPR017448; IPR009003; Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Macaca mulatta (Rhesus macaque) TR43139_c1_g1_i3 Q9UGM3 DMBT1_HUMAN 1.00E-132 GO:0048306; GO:0051607; GO:0030855; GO:0005576; GO:0019898; GO:0043152; GO:0045087; GO:0001833; GO:0019048; GO:0030670; GO:0030858; GO:0015031; GO:0005578; GO:0005044; GO:0008329; GO:0035375; GO:0042589 calcium-dependent protein binding; defense response to virus; epithelial cell differentiation; extracellular region; extrinsic to membrane; induction of bacterial agglutination; innate immune response; inner cell mass cell proliferation; modulation by virus of host morphology or physiology; phagocytic vesicle membrane; positive regulation of epithelial cell differentiation; protein transport; proteinaceous extracellular matrix; scavenger receptor activity; signaling pattern recognition receptor activity; zymogen binding; zymogen granule membrane IPR000859; IPR001190; IPR017448; IPR001507; IPR017977; Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) TR43139_c1_g1_i5 Q05319 STUB_DROME 2.00E-52 GO:0051017; GO:0016021; GO:0005886; GO:0006508; GO:0004252 actin filament bundle assembly; integral to membrane; plasma membrane; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Serine proteinase stubble (EC 3.4.21.-) (Protein stubble-stubbloid) [Cleaved into: Serine proteinase stubble non-catalytic chain; Serine proteinase stubble catalytic chain] Sb Sb-sbd CG4316 Drosophila melanogaster (Fruit fly) TR43139_c1_g3_i1 P30204 MSRE_MOUSE 3.00E-25 GO:0030301; GO:0005581; GO:0016021; GO:0042953; GO:0034362; GO:0030169; GO:0034381; GO:0005886; GO:0010886; GO:0010744; GO:0005044 cholesterol transport; collagen; integral to membrane; lipoprotein transport; low-density lipoprotein particle; low-density lipoprotein particle binding; plasma lipoprotein particle clearance; plasma membrane; positive regulation of cholesterol storage; positive regulation of macrophage derived foam cell differentiation; scavenger receptor activity IPR008160; IPR003543; IPR001190; IPR017448; Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor type A) (SR-A) (CD antigen CD204) Msr1 Scvr Mus musculus (Mouse) TR43139_c1_g3_i2 P30204 MSRE_MOUSE 5.00E-25 GO:0030301; GO:0005581; GO:0016021; GO:0042953; GO:0034362; GO:0030169; GO:0034381; GO:0005886; GO:0010886; GO:0010744; GO:0005044 cholesterol transport; collagen; integral to membrane; lipoprotein transport; low-density lipoprotein particle; low-density lipoprotein particle binding; plasma lipoprotein particle clearance; plasma membrane; positive regulation of cholesterol storage; positive regulation of macrophage derived foam cell differentiation; scavenger receptor activity IPR008160; IPR003543; IPR001190; IPR017448; Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor type A) (SR-A) (CD antigen CD204) Msr1 Scvr Mus musculus (Mouse) TR43140_c1_g1_i4 Q14974 IMB1_HUMAN 7.00E-160 GO:0006607; GO:0006309; GO:0019221; GO:0005829; GO:0075733; GO:0019048; GO:0008139; GO:0031965; GO:0005643; GO:0005654; GO:0000060; GO:0008565; GO:0006610; GO:0044281; GO:0008270 P04626; P03101; P03107; Q8K4J6; P14907; Q16637-3; O75940 "NLS-bearing protein import into nucleus; apoptotic DNA fragmentation; cytokine-mediated signaling pathway; cytosol; intracellular transport of viral material; modulation by virus of host morphology or physiology; nuclear localization sequence binding; nuclear membrane; nuclear pore; nucleoplasm; protein import into nucleus, translocation; protein transporter activity; ribosomal protein import into nucleus; small molecule metabolic process; zinc ion binding" IPR011989; IPR016024; IPR000225; IPR021133; IPR001494; IPR027140; Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) KPNB1 NTF97 Homo sapiens (Human) TR43140_c1_g2_i1 Q14974 IMB1_HUMAN 0 GO:0006607; GO:0006309; GO:0019221; GO:0005829; GO:0075733; GO:0019048; GO:0008139; GO:0031965; GO:0005643; GO:0005654; GO:0000060; GO:0008565; GO:0006610; GO:0044281; GO:0008270 P04626; P03101; P03107; Q8K4J6; P14907; Q16637-3; O75940 "NLS-bearing protein import into nucleus; apoptotic DNA fragmentation; cytokine-mediated signaling pathway; cytosol; intracellular transport of viral material; modulation by virus of host morphology or physiology; nuclear localization sequence binding; nuclear membrane; nuclear pore; nucleoplasm; protein import into nucleus, translocation; protein transporter activity; ribosomal protein import into nucleus; small molecule metabolic process; zinc ion binding" IPR011989; IPR016024; IPR000225; IPR021133; IPR001494; IPR027140; Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) KPNB1 NTF97 Homo sapiens (Human) TR43140_c1_g2_i2 Q8BFY9 TNPO1_MOUSE 4.00E-09 GO:0005737; GO:0006886; GO:0005634 cytoplasm; intracellular protein transport; nucleus IPR011989; IPR016024; IPR001494; Transportin-1 (Importin beta-2) (Karyopherin beta-2) Tnpo1 Kpnb2 Mus musculus (Mouse) TR43141_c2_g4_i1 O35711 LIPB2_MOUSE 2.00E-104 GO:0003677; GO:0008907 DNA binding; integrase activity IPR004191; IPR001660; IPR013761; IPR011510; IPR021129; Liprin-beta-2 (Coiled-coil-like protein 1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) Ppfibp2 Cclp1 Mus musculus (Mouse) TR43141_c2_g4_i3 Q8C8U0 LIPB1_MOUSE 1.00E-106 IPR001660; IPR013761; IPR011510; IPR021129; Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) Ppfibp1 Kiaa1230 Mus musculus (Mouse) TR43141_c2_g4_i4 Q8C8U0 LIPB1_MOUSE 2.00E-105 IPR001660; IPR013761; IPR011510; IPR021129; Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) Ppfibp1 Kiaa1230 Mus musculus (Mouse) TR43142_c3_g2_i1 Q8TGM7 ART2_YEAST 1.00E-19 Putative uncharacterized protein ART2 (Antisense to ribosomal RNA transcript protein 2) ART2 YLR154W-A YLR154W-C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR43142_c3_g2_i11 Q8TGM7 ART2_YEAST 3.00E-18 Putative uncharacterized protein ART2 (Antisense to ribosomal RNA transcript protein 2) ART2 YLR154W-A YLR154W-C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR43142_c3_g3_i1 P0CI21 TE53_IMPHE 2.00E-08 GO:0005576 extracellular region Augerpeptide hhe53 Impages hectica (Sea snail) (Hastula hectica) TR43143_c4_g1_i1 Q8VDH1 FBX21_MOUSE 2.00E-14 GO:0003677 DNA binding IPR001810; IPR011722; F-box only protein 21 Fbxo21 Fbx21 Kiaa0875 Mus musculus (Mouse) TR43143_c4_g1_i2 Q8VDH1 FBX21_MOUSE 2.00E-14 GO:0003677 DNA binding IPR001810; IPR011722; F-box only protein 21 Fbxo21 Fbx21 Kiaa0875 Mus musculus (Mouse) TR43147_c1_g2_i1 Q7T0Q1 MTPN_XENLA 4.00E-30 GO:0005634; GO:0048471 nucleus; perinuclear region of cytoplasm IPR002110; IPR020683; Myotrophin mtpn Xenopus laevis (African clawed frog) TR43147_c1_g2_i2 Q7T2B9 MTPN_DANRE 3.00E-32 GO:0005634; GO:0048471 nucleus; perinuclear region of cytoplasm IPR002110; IPR020683; Myotrophin mtpn Danio rerio (Zebrafish) (Brachydanio rerio) TR43148_c1_g2_i2 Q1ZXD6 ROCO5_DICDI 9.00E-08 GO:0005524; GO:0005525; GO:0005089; GO:0005622; GO:0005543; GO:0004674; GO:0035023; GO:0007264; GO:0030587 ATP binding; GTP binding; Rho guanyl-nucleotide exchange factor activity; intracellular; phospholipid binding; protein serine/threonine kinase activity; regulation of Rho protein signal transduction; small GTPase mediated signal transduction; sorocarp development IPR000219; IPR011009; IPR001611; IPR025875; IPR003591; IPR013684; IPR027417; IPR011993; IPR001849; IPR000719; IPR017441; IPR020859; IPR001245; IPR008271; IPR001806; Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) TR43149_c1_g1_i1 Q922J3 CLIP1_MOUSE 8.00E-21 GO:0005813; GO:0005881; GO:0030659; GO:0044354; GO:0008017; GO:0001578; GO:0035371; GO:0003676; GO:0031116; GO:0001726; GO:0006810; GO:0008270 centrosome; cytoplasmic microtubule; cytoplasmic vesicle membrane; macropinosome; microtubule binding; microtubule bundle formation; microtubule plus end; nucleic acid binding; positive regulation of microtubule polymerization; ruffle; transport; zinc ion binding IPR000938; IPR001878; CAP-Gly domain-containing linker protein 1 (Restin) Clip1 Kiaa4046 Rsn Mus musculus (Mouse) TR43149_c1_g1_i2 Q5R686 CLIP3_PONAB 3.00E-20 GO:0005795; GO:0072321; GO:0031901; GO:0045444; GO:0035594; GO:0044091; GO:0045121; GO:0008017; GO:0031115; GO:0018230; GO:0005886; GO:0043065; GO:0045807; GO:0090004; GO:0010828; GO:0001934; GO:0055038; GO:0032588 Golgi stack; chaperone-mediated protein transport; early endosome membrane; fat cell differentiation; ganglioside binding; membrane biogenesis; membrane raft; microtubule binding; negative regulation of microtubule polymerization; peptidyl-L-cysteine S-palmitoylation; plasma membrane; positive regulation of apoptotic process; positive regulation of endocytosis; positive regulation of establishment of protein localization to plasma membrane; positive regulation of glucose transport; positive regulation of protein phosphorylation; recycling endosome membrane; trans-Golgi network membrane IPR002110; IPR020683; IPR000938; CAP-Gly domain-containing linker protein 3 (Cytoplasmic linker protein 170-related 59 kDa protein) (CLIP-170-related 59 kDa protein) (CLIPR-59) CLIP3 CLIPR59 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR43149_c1_g3_i2 Q5JR59 MTUS2_HUMAN 1.00E-25 GO:0005737; GO:0005874; GO:0008017 Q99661; Q15691; P25786 cytoplasm; microtubule; microtubule binding Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa) MTUS2 CAZIP KIAA0774 TIP150 Homo sapiens (Human) TR43149_c1_g3_i3 Q3UHD3 MTUS2_MOUSE 2.00E-26 GO:0005813; GO:0005881; GO:0008017; GO:0042803 centrosome; cytoplasmic microtubule; microtubule binding; protein homodimerization activity Microtubule-associated tumor suppressor candidate 2 homolog (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa) Mtus2 Cazip Kiaa0774 Tip150 Mus musculus (Mouse) TR43149_c1_g3_i5 Q3UHD3 MTUS2_MOUSE 2.00E-26 GO:0005813; GO:0005881; GO:0008017; GO:0042803 centrosome; cytoplasmic microtubule; microtubule binding; protein homodimerization activity Microtubule-associated tumor suppressor candidate 2 homolog (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa) Mtus2 Cazip Kiaa0774 Tip150 Mus musculus (Mouse) TR43150_c5_g1_i1 Q95254 GHSR_PIG 2.00E-07 GO:0008154; GO:0008343; GO:0009986; GO:0032869; GO:0046697; GO:0001616; GO:0030252; GO:0016520; GO:0009755; GO:0016021; GO:0045121; GO:0050728; GO:0032691; GO:0045409; GO:0042536; GO:0043005; GO:0005886; GO:0032100; GO:0043568; GO:0040018; GO:0051963; GO:0032094 actin polymerization or depolymerization; adult feeding behavior; cell surface; cellular response to insulin stimulus; decidualization; growth hormone secretagogue receptor activity; growth hormone secretion; growth hormone-releasing hormone receptor activity; hormone-mediated signaling pathway; integral to membrane; membrane raft; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 biosynthetic process; negative regulation of tumor necrosis factor biosynthetic process; neuron projection; plasma membrane; positive regulation of appetite; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; regulation of synapse assembly; response to food IPR003905; IPR000276; IPR017452; Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) GHSR Sus scrofa (Pig) TR43150_c5_g1_i2 Q95254 GHSR_PIG 4.00E-08 GO:0008154; GO:0008343; GO:0009986; GO:0032869; GO:0046697; GO:0001616; GO:0030252; GO:0016520; GO:0009755; GO:0016021; GO:0045121; GO:0050728; GO:0032691; GO:0045409; GO:0042536; GO:0043005; GO:0005886; GO:0032100; GO:0043568; GO:0040018; GO:0051963; GO:0032094 actin polymerization or depolymerization; adult feeding behavior; cell surface; cellular response to insulin stimulus; decidualization; growth hormone secretagogue receptor activity; growth hormone secretion; growth hormone-releasing hormone receptor activity; hormone-mediated signaling pathway; integral to membrane; membrane raft; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 biosynthetic process; negative regulation of tumor necrosis factor biosynthetic process; neuron projection; plasma membrane; positive regulation of appetite; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; regulation of synapse assembly; response to food IPR003905; IPR000276; IPR017452; Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) GHSR Sus scrofa (Pig) TR43153_c1_g2_i1 F1Q4S1 ATP9B_DANRE 0 GO:0005524; GO:0005794; GO:0019829; GO:0016021; GO:0000287; GO:0004012 ATP binding; Golgi apparatus; cation-transporting ATPase activity; integral to membrane; magnesium ion binding; phospholipid-translocating ATPase activity IPR023299; IPR018303; IPR006539; IPR008250; IPR001757; IPR023214; Probable phospholipid-transporting ATPase IIB (EC 3.6.3.1) (ATPase class II type 9B) atp9b Danio rerio (Zebrafish) (Brachydanio rerio) TR43153_c1_g2_i2 D4ABB8 ATP9B_RAT 0 GO:0005524; GO:0005794; GO:0019829; GO:0072600; GO:0016021; GO:0000287; GO:0048471; GO:0004012; GO:0005802 ATP binding; Golgi apparatus; cation-transporting ATPase activity; establishment of protein localization to Golgi; integral to membrane; magnesium ion binding; perinuclear region of cytoplasm; phospholipid-translocating ATPase activity; trans-Golgi network IPR023299; IPR018303; IPR006539; IPR008250; IPR001757; IPR023214; Probable phospholipid-transporting ATPase IIB (EC 3.6.3.1) (ATPase class II type 9B) Atp9b Rattus norvegicus (Rat) TR43154_c2_g2_i1 P30683 GNAO_LYMST 0 GO:0005525; GO:0003924; GO:0007188; GO:0046872; GO:0004871 GTP binding; GTPase activity; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; metal ion binding; signal transducer activity IPR001408; IPR001019; IPR011025; IPR027417; Guanine nucleotide-binding protein G(o) subunit alpha Lymnaea stagnalis (Great pond snail) TR43155_c0_g1_i1 Q8C088 EGFEM_MOUSE 6.00E-63 GO:0005509 calcium ion binding IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR011489; IPR009030; EGF-like and EMI domain-containing protein 1 Egfem1 Mus musculus (Mouse) TR43155_c0_g1_i5 Q80V70 MEGF6_MOUSE 0 GO:0005509; GO:0005576 calcium ion binding; extracellular region IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR013111; IPR002049; IPR011489; IPR009030; Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) TR43157_c0_g1_i12 O13124 VDR_XENLA 3.00E-49 GO:0008434; GO:0005634; GO:0043565; GO:0003707; GO:0070561; GO:0008270 calcitriol receptor activity; nucleus; sequence-specific DNA binding; steroid hormone receptor activity; vitamin D receptor signaling pathway; zinc ion binding IPR008946; IPR000536; IPR001723; IPR000324; IPR001628; IPR013088; "Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1)" vdr nr1i1 Xenopus laevis (African clawed frog) TR43157_c0_g1_i3 Q24143 HR96_DROME 5.00E-31 GO:0000977; GO:0042632; GO:0004879; GO:0005634; GO:0070873; GO:0042594; GO:0003707; GO:0070328; GO:0008270 RNA polymerase II regulatory region sequence-specific DNA binding; cholesterol homeostasis; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleus; regulation of glycogen metabolic process; response to starvation; steroid hormone receptor activity; triglyceride homeostasis; zinc ion binding IPR008946; IPR000536; IPR001628; IPR013088; Nuclear hormone receptor HR96 (dHR96) (Nuclear receptor subfamily 1 group J member 1) Hr96 NR1J1 CG11783 Drosophila melanogaster (Fruit fly) TR43158_c1_g2_i1 Q5R4F4 SC31A_PONAB 0 GO:0030134; GO:0012507; GO:0005789; GO:0015031; GO:0016192 ER to Golgi transport vesicle; ER to Golgi transport vesicle membrane; endoplasmic reticulum membrane; protein transport; vesicle-mediated transport IPR015943; IPR001680; IPR017986; Protein transport protein Sec31A (SEC31-like protein 1) (SEC31-related protein A) SEC31A SEC31L1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR43158_c1_g4_i4 Q9Z2Q1 SC31A_RAT 1.00E-28 GO:0030134; GO:0012507; GO:0005789; GO:0005768; GO:0015031; GO:0016192 ER to Golgi transport vesicle; ER to Golgi transport vesicle membrane; endoplasmic reticulum membrane; endosome; protein transport; vesicle-mediated transport IPR015943; IPR001680; IPR017986; Protein transport protein Sec31A (SEC31-like protein 1) (SEC31-related protein A) (Vesicle-associated protein 1) Sec31a Sec31l1 Vap1 Rattus norvegicus (Rat) TR43160_c2_g2_i1 Q99PI5 LPIN2_MOUSE 4.00E-55 GO:0005829; GO:0005789; GO:0006631; GO:0006629; GO:0005634; GO:0008195; GO:0045944; GO:0003713; GO:0006351 "cytosol; endoplasmic reticulum membrane; fatty acid metabolic process; lipid metabolic process; nucleus; phosphatidate phosphatase activity; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcription, DNA-dependent" IPR023214; IPR007651; IPR013209; IPR026744; Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) Lpin2 Mus musculus (Mouse) TR43160_c2_g2_i2 Q7TNN8 LPIN3_MUSSP 5.00E-37 GO:0006631; GO:0005634; GO:0008195 fatty acid metabolic process; nucleus; phosphatidate phosphatase activity IPR023214; IPR007651; IPR013209; Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) Lpin3 Mus spretus (Western Mediterranean mouse) (Algerian mouse) TR43160_c2_g2_i3 Q99PI5 LPIN2_MOUSE 4.00E-127 GO:0005829; GO:0005789; GO:0006631; GO:0006629; GO:0005634; GO:0008195; GO:0045944; GO:0003713; GO:0006351 "cytosol; endoplasmic reticulum membrane; fatty acid metabolic process; lipid metabolic process; nucleus; phosphatidate phosphatase activity; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcription, DNA-dependent" IPR023214; IPR007651; IPR013209; IPR026744; Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) Lpin2 Mus musculus (Mouse) TR43160_c2_g2_i5 Q92539 LPIN2_HUMAN 2.00E-129 GO:0005829; GO:0005789; GO:0006631; GO:0005634; GO:0008195; GO:0006656; GO:0006646; GO:0045944; GO:0003713; GO:0006351; GO:0019432 "cytosol; endoplasmic reticulum membrane; fatty acid metabolic process; nucleus; phosphatidate phosphatase activity; phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcription, DNA-dependent; triglyceride biosynthetic process" IPR023214; IPR007651; IPR013209; IPR026744; Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) LPIN2 KIAA0249 Homo sapiens (Human) TR43160_c2_g2_i6 Q92539 LPIN2_HUMAN 6.00E-128 GO:0005829; GO:0005789; GO:0006631; GO:0005634; GO:0008195; GO:0006656; GO:0006646; GO:0045944; GO:0003713; GO:0006351; GO:0019432 "cytosol; endoplasmic reticulum membrane; fatty acid metabolic process; nucleus; phosphatidate phosphatase activity; phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcription, DNA-dependent; triglyceride biosynthetic process" IPR023214; IPR007651; IPR013209; IPR026744; Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) LPIN2 KIAA0249 Homo sapiens (Human) TR43160_c2_g2_i7 Q9BQK8 LPIN3_HUMAN 2.00E-117 GO:0005789; GO:0006631; GO:0005634; GO:0008195; GO:0006656; GO:0006646 endoplasmic reticulum membrane; fatty acid metabolic process; nucleus; phosphatidate phosphatase activity; phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process IPR023214; IPR007651; IPR013209; Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like) LPIN3 LIPN3L Homo sapiens (Human) TR43163_c0_g2_i1 P50131 PE2R3_PIG 6.00E-36 GO:0007188; GO:0015701; GO:0007204; GO:0001660; GO:0016021; GO:0007200; GO:0005886; GO:0035810; GO:0004957; GO:0032496 adenylate cyclase-modulating G-protein coupled receptor signaling pathway; bicarbonate transport; elevation of cytosolic calcium ion concentration; fever generation; integral to membrane; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; positive regulation of urine volume; prostaglandin E receptor activity; response to lipopolysaccharide IPR001481; IPR000276; IPR017452; IPR008365; IPR001244; IPR000265; Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (Prostanoid EP3 receptor) PTGER3 Sus scrofa (Pig) TR43166_c1_g1_i4 P28289 TMOD1_HUMAN 4.00E-42 GO:0008344; GO:0030863; GO:0005829; GO:0016020; GO:0030049; GO:0030016; GO:0030239 adult locomotory behavior; cortical cytoskeleton; cytosol; membrane; muscle filament sliding; myofibril; myofibril assembly IPR004934; Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod) TMOD1 D9S57E TMOD Homo sapiens (Human) TR43167_c2_g1_i1 P21329 RTJK_DROFU 5.00E-33 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) TR43167_c2_g1_i7 P21329 RTJK_DROFU 4.00E-33 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) TR43168_c4_g2_i1 Q8YK97 LILIP_NOSS1 2.00E-07 GO:0004096; GO:0020037; GO:0046872; GO:0016702; GO:0031408 "catalase activity; heme binding; metal ion binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; oxylipin biosynthetic process" IPR020835; IPR011614; IPR000907; IPR013819; Lipid metabolism; oxylipin biosynthesis. Linolenate 9R-lipoxygenase (EC 1.13.11.61) (NspLOX) all8020 Nostoc sp. (strain PCC 7120 / UTEX 2576) TR43168_c4_g2_i2 O16025 AOSL_PLEHO 3.00E-61 GO:0047677; GO:0019369; GO:0004096; GO:0005737; GO:0020037; GO:0047987; GO:0005506; GO:0016020; GO:0031408 arachidonate 8(R)-lipoxygenase activity; arachidonic acid metabolic process; catalase activity; cytoplasm; heme binding; hydroperoxide dehydratase activity; iron ion binding; membrane; oxylipin biosynthetic process IPR020835; IPR011614; IPR008976; IPR000907; IPR013819; IPR020834; IPR020833; IPR001885; IPR001024; Lipid metabolism; arachidonate metabolism. Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (EC 4.2.1.92) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)] Plexaura homomalla (Black sea rod) TR43169_c2_g4_i3 P18173 DHGL_DROME 1.00E-104 GO:0006066; GO:0008812; GO:0005576; GO:0050660; GO:0004344; GO:0006006; GO:0008364; GO:0046693 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding; glucose dehydrogenase activity; glucose metabolic process; pupal chitin-based cuticle development; sperm storage IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld CG1152 Drosophila melanogaster (Fruit fly) TR43169_c2_g5_i1 Q8PPG8 BETA_XANAC 1.00E-14 GO:0008802; GO:0008812; GO:0050660; GO:0019285 betaine-aldehyde dehydrogenase activity; choline dehydrogenase activity; flavin adenine dinucleotide binding; glycine betaine biosynthetic process from choline IPR011533; IPR012132; IPR000172; IPR007867; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. Oxygen-dependent choline dehydrogenase (CDH) (CHD) (EC 1.1.99.1) (Betaine aldehyde dehydrogenase) (BADH) (EC 1.2.1.8) betA XAC0718 Xanthomonas axonopodis pv. citri (strain 306) TR43171_c1_g3_i2 O35857 TIM44_MOUSE 1.00E-92 GO:0005524; GO:0015450; GO:0006886; GO:0005743; GO:0005759 ATP binding; P-P-bond-hydrolysis-driven protein transmembrane transporter activity; intracellular protein transport; mitochondrial inner membrane; mitochondrial matrix IPR017303; IPR007379; Mitochondrial import inner membrane translocase subunit TIM44 Timm44 Mimt44 Tim44 Mus musculus (Mouse) TR43171_c1_g5_i1 Q8SX83 SPEN_DROME 2.00E-57 GO:0003723; GO:0016055; GO:0007411; GO:0048749; GO:0050832; GO:0007173; GO:0048106; GO:0007403; GO:0008586; GO:0035321; GO:0007400; GO:0000166; GO:0005634; GO:0007422; GO:0030177; GO:0006355; GO:0007379; GO:0006351; GO:0035222 "RNA binding; Wnt receptor signaling pathway; axon guidance; compound eye development; defense response to fungus; epidermal growth factor receptor signaling pathway; establishment of thoracic bristle planar orientation; glial cell fate determination; imaginal disc-derived wing vein morphogenesis; maintenance of imaginal disc-derived wing hair orientation; neuroblast fate determination; nucleotide binding; nucleus; peripheral nervous system development; positive regulation of Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; segment specification; transcription, DNA-dependent; wing disc pattern formation" IPR012677; IPR000504; IPR012921; IPR016194; IPR010912; Protein split ends spen CG18497 Drosophila melanogaster (Fruit fly) TR43173_c1_g1_i1 Q9DBU0 TM9S1_MOUSE 0 GO:0000421; GO:0006914; GO:0031410; GO:0016021; GO:0005765 autophagic vacuole membrane; autophagy; cytoplasmic vesicle; integral to membrane; lysosomal membrane IPR004240; Transmembrane 9 superfamily member 1 Tm9sf1 Mus musculus (Mouse) TR43174_c1_g1_i1 P07207 NOTCH_DROME 0 GO:0005796; GO:0061382; GO:0007219; GO:0048052; GO:0007464; GO:0045466; GO:0045463; GO:0007460; GO:0007015; GO:0005912; GO:0008356; GO:0007298; GO:0005509; GO:0009986; GO:0008407; GO:0003682; GO:0042676; GO:0046667; GO:0005829; GO:0008340; GO:0046843; GO:0007391; GO:0007451; GO:0007398; GO:0035165; GO:0005788; GO:0005768; GO:0061331; GO:0035153; GO:0035214; GO:0007440; GO:0060288; GO:0030718; GO:0030708; GO:0007403; GO:0008347; GO:0035172; GO:0007157; GO:0007446; GO:0016348; GO:0048803; GO:0008587; GO:0007474; GO:0016021; GO:0035171; GO:0046331; GO:0007616; GO:0035170; GO:0007498; GO:0008045; GO:0007521; GO:0046329; GO:0045316; GO:0035157; GO:0050768; GO:0035155; GO:0000122; GO:0007400; GO:0005654; GO:0007314; GO:0030720; GO:0030713; GO:0007422; GO:1900087; GO:0045747; GO:0008284; GO:0045944; GO:0043234; GO:0045468; GO:0042686; GO:0042689; GO:0051489; GO:0040008; GO:0009608; GO:0016330; GO:0007519; GO:0035003; GO:0006351; GO:0004888; GO:0007419; GO:0048190; GO:0007473 Q24279; P10041; P28159 "Golgi lumen; Malpighian tubule tip cell differentiation; Notch signaling pathway; R1/R6 cell differentiation; R3/R4 cell fate commitment; R7 cell differentiation; R8 cell development; R8 cell fate commitment; actin filament organization; adherens junction; asymmetric cell division; border follicle cell migration; calcium ion binding; cell surface; chaeta morphogenesis; chromatin binding; compound eye cone cell fate commitment; compound eye retinal cell programmed cell death; cytosol; determination of adult lifespan; dorsal appendage formation; dorsal closure; dorsal/ventral lineage restriction, imaginal disc; ectoderm development; embryonic crystal cell differentiation; endoplasmic reticulum lumen; endosome; epithelial cell proliferation involved in Malpighian tubule morphogenesis; epithelial cell type specification, open tracheal system; eye-antennal disc development; foregut morphogenesis; formation of a compartment boundary; germ-line stem cell maintenance; germarium-derived female germ-line cyst encapsulation; glial cell fate determination; glial cell migration; hemocyte proliferation; heterophilic cell-cell adhesion; imaginal disc growth; imaginal disc-derived leg joint morphogenesis; imaginal disc-derived male genitalia morphogenesis; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein specification; integral to membrane; lamellocyte differentiation; lateral inhibition; long-term memory; lymph gland crystal cell differentiation; mesoderm development; motor neuron axon guidance; muscle cell fate determination; negative regulation of JNK cascade; negative regulation of compound eye photoreceptor development; negative regulation of fusion cell fate specification; negative regulation of neurogenesis; negative regulation of terminal cell fate specification, open tracheal system; negative regulation of transcription from RNA polymerase II promoter; neuroblast fate determination; nucleoplasm; oocyte anterior/posterior axis specification; oocyte localization involved in germarium-derived egg chamber formation; ovarian follicle cell stalk formation; peripheral nervous system development; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of Notch signaling pathway; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; protein complex; regulation of R8 cell spacing in compound eye; regulation of cardioblast cell fate specification; regulation of crystal cell differentiation; regulation of filopodium assembly; regulation of growth; response to symbiont; second mitotic wave involved in compound eye morphogenesis; skeletal muscle tissue development; subapical complex; transcription, DNA-dependent; transmembrane signaling receptor activity; ventral cord development; wing disc dorsal/ventral pattern formation; wing disc proximal/distal pattern formation" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR000800; IPR010660; IPR011656; Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) TR43174_c1_g2_i1 Q01705 NOTC1_MOUSE 0 GO:0000139; GO:0002193; GO:0003270; GO:0001190; GO:0042640; GO:0003180; GO:1902263; GO:0060842; GO:0003162; GO:0003181; GO:0009912; GO:0007409; GO:0048754; GO:0005509; GO:0003214; GO:0060038; GO:0003213; GO:0003219; GO:0060411; GO:0060948; GO:0001708; GO:0003273; GO:0009986; GO:0071372; GO:0035924; GO:0031490; GO:0072044; GO:0007386; GO:0001047; GO:0060982; GO:0003169; GO:0005856; GO:0005829; GO:0072017; GO:0035116; GO:0060956; GO:0003160; GO:0007492; GO:0005789; GO:0004857; GO:0003198; GO:0005576; GO:0030900; GO:0007440; GO:0010001; GO:0072144; GO:0003241; GO:0031069; GO:0001947; GO:0006959; GO:0001701; GO:0002437; GO:0005887; GO:0072602; GO:0030216; GO:0030027; GO:0070986; GO:0001889; GO:0030324; GO:0003192; GO:0030514; GO:2000811; GO:0045955; GO:0090090; GO:0060548; GO:0090051; GO:0010812; GO:2001027; GO:0060253; GO:0045662; GO:0010832; GO:0048715; GO:0030279; GO:0045668; GO:0046533; GO:2000974; GO:2000737; GO:0000122; GO:0021915; GO:0097150; GO:0005654; GO:0002051; GO:0003344; GO:0030513; GO:0046427; GO:0043065; GO:0048711; GO:0060045; GO:0030335; GO:1901189; GO:0050679; GO:0010718; GO:0045618; GO:0061419; GO:0007221; GO:0060740; GO:0003184; GO:0004872; GO:0061344; GO:0060768; GO:1901201; GO:0014807; GO:0003256; GO:0032495; GO:0001726; GO:0060528; GO:0043565; GO:0003700; GO:0035914; GO:0048103; GO:0002040; GO:0035148; GO:0060979; GO:0060843; GO:0060412; GO:0003222 Q06330; P31266; P28159 Golgi membrane; MAML1-RBP-Jkappa- ICN1 complex; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation; RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; anagen; aortic valve morphogenesis; apoptotic process involved in embryonic digit morphogenesis; arterial endothelial cell differentiation; atrioventricular node development; atrioventricular valve morphogenesis; auditory receptor cell fate commitment; axonogenesis; branching morphogenesis of an epithelial tube; calcium ion binding; cardiac left ventricle morphogenesis; cardiac muscle cell proliferation; cardiac right atrium morphogenesis; cardiac right ventricle formation; cardiac septum morphogenesis; cardiac vascular smooth muscle cell development; cell fate specification; cell migration involved in endocardial cushion formation; cell surface; cellular response to follicle-stimulating hormone stimulus; cellular response to vascular endothelial growth factor stimulus; chromatin DNA binding; collecting duct development; compartment pattern specification; core promoter binding; coronary artery morphogenesis; coronary vein morphogenesis; cytoskeleton; cytosol; distal tubule development; embryonic hindlimb morphogenesis; endocardial cell differentiation; endocardium morphogenesis; endoderm development; endoplasmic reticulum membrane; enzyme inhibitor activity; epithelial to mesenchymal transition involved in endocardial cushion formation; extracellular region; forebrain development; foregut morphogenesis; glial cell differentiation; glomerular mesangial cell development; growth involved in heart morphogenesis; hair follicle morphogenesis; heart looping; humoral immune response; in utero embryonic development; inflammatory response to antigenic stimulus; integral to plasma membrane; interleukin-4 secretion; keratinocyte differentiation; lamellipodium; left/right axis specification; liver development; lung development; mitral valve formation; negative regulation of BMP signaling pathway; negative regulation of anoikis; negative regulation of calcium ion-dependent exocytosis; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of cell death; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell-substrate adhesion; negative regulation of endothelial cell chemotaxis; negative regulation of glial cell proliferation; negative regulation of myoblast differentiation; negative regulation of myotube differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of ossification; negative regulation of osteoblast differentiation; negative regulation of photoreceptor cell differentiation; negative regulation of pro-B cell differentiation; negative regulation of stem cell differentiation; negative regulation of transcription from RNA polymerase II promoter; neural tube development; neuronal stem cell maintenance; nucleoplasm; osteoblast fate commitment; pericardium morphogenesis; positive regulation of BMP signaling pathway; positive regulation of JAK-STAT cascade; positive regulation of apoptotic process; positive regulation of astrocyte differentiation; positive regulation of cardiac muscle cell proliferation; positive regulation of cell migration; positive regulation of ephrin receptor signaling pathway; positive regulation of epithelial cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription of Notch receptor target; prostate gland epithelium morphogenesis; pulmonary valve morphogenesis; receptor activity; regulation of cell adhesion involved in heart morphogenesis; regulation of epithelial cell proliferation involved in prostate gland development; regulation of extracellular matrix assembly; regulation of somitogenesis; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation; response to muramyl dipeptide; ruffle; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; skeletal muscle cell differentiation; somatic stem cell division; sprouting angiogenesis; tube formation; vasculogenesis involved in coronary vascular morphogenesis; venous endothelial cell differentiation; ventricular septum morphogenesis; ventricular trabecula myocardium morphogenesis IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR022362; IPR000800; IPR010660; IPR011656; Neurogenic locus notch homolog protein 1 (Notch 1) (Motch A) (mT14) (p300) [Cleaved into: Notch 1 extracellular truncation; Notch 1 intracellular domain (NICD)] Notch1 Motch Mus musculus (Mouse) TR43175_c5_g1_i1 Q9R1R2 TRIM3_MOUSE 5.00E-07 GO:0005737; GO:0005769; GO:0015031; GO:0008270 cytoplasm; early endosome; protein transport; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) TR43175_c5_g1_i10 Q9C040 TRIM2_HUMAN 4.00E-08 GO:0005737; GO:0043523; GO:0004842; GO:0008270 cytoplasm; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) TRIM2 KIAA0517 RNF86 Homo sapiens (Human) TR43175_c5_g1_i6 A4IF63 TRIM2_BOVIN 5.00E-08 GO:0005737; GO:0043523; GO:0004842; GO:0008270 cytoplasm; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) TR43175_c5_g1_i9 Q9ESN6 TRIM2_MOUSE 2.00E-07 GO:0005737; GO:0017022; GO:0043523; GO:0004842; GO:0008270 cytoplasm; myosin binding; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) TR43176_c1_g2_i1 Q5VVW2 GARL3_HUMAN 0 GO:0005096; GO:0043547; GO:0051056; GO:0005083 GTPase activator activity; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; small GTPase regulator activity IPR001180; IPR000331; GTPase-activating Rap/Ran-GAP domain-like protein 3 GARNL3 Homo sapiens (Human) TR43177_c3_g2_i3 P84549 TBA_POPEU 1.00E-13 GO:0005525; GO:0005737; GO:0005874; GO:0007017 GTP binding; cytoplasm; microtubule; microtubule-based process IPR000217; IPR003008; Tubulin alpha chain (Fragments) Populus euphratica (Euphrates poplar) TR43177_c3_g2_i4 P06603 TBA1_DROME 0 GO:0005525; GO:0003924; GO:0019730; GO:0000235; GO:0005813; GO:0007094; GO:0007052; GO:0051258; GO:0005200 GTP binding; GTPase activity; antimicrobial humoral response; astral microtubule; centrosome; mitotic spindle assembly checkpoint; mitotic spindle organization; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-1 chain alphaTub84B tubA84B CG1913 Drosophila melanogaster (Fruit fly) TR43178_c0_g2_i1 Q8N539 FBCD1_HUMAN 3.00E-64 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 UNQ701/PRO1346 Homo sapiens (Human) TR43178_c0_g2_i2 Q5M8C6 FGL1_RAT 2.00E-52 GO:0005576 extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen-like protein 1 Fgl1 Rattus norvegicus (Rat) TR43178_c0_g2_i3 Q9BY76 ANGL4_HUMAN 8.00E-38 GO:0001525; GO:0030154; GO:0044255; GO:0004857; GO:0005615; GO:0043066; GO:0051005; GO:0045766; GO:0051260; GO:0005578; GO:0001666; GO:0044281; GO:0070328 P05556; P18084 angiogenesis; cell differentiation; cellular lipid metabolic process; enzyme inhibitor activity; extracellular space; negative regulation of apoptotic process; negative regulation of lipoprotein lipase activity; positive regulation of angiogenesis; protein homooligomerization; proteinaceous extracellular matrix; response to hypoxia; small molecule metabolic process; triglyceride homeostasis IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-related protein 4 (Angiopoietin-like protein 4) (Hepatic fibrinogen/angiopoietin-related protein) (HFARP) ANGPTL4 ARP4 HFARP PGAR PP1158 PSEC0166 UNQ171/PRO197 Homo sapiens (Human) TR43178_c0_g2_i5 Q8N539 FBCD1_HUMAN 1.00E-67 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 UNQ701/PRO1346 Homo sapiens (Human) TR43180_c3_g1_i1 P50416 CPT1A_HUMAN 1.00E-51 GO:0004095; GO:0009437; GO:0006853; GO:0042755; GO:0006635; GO:0006006; GO:0031307; GO:0001676; GO:0005743; GO:0032000; GO:0051260; GO:0050796; GO:0042493; GO:0014070; GO:0006641 carnitine O-palmitoyltransferase activity; carnitine metabolic process; carnitine shuttle; eating behavior; fatty acid beta-oxidation; glucose metabolic process; integral to mitochondrial outer membrane; long-chain fatty acid metabolic process; mitochondrial inner membrane; positive regulation of fatty acid beta-oxidation; protein homooligomerization; regulation of insulin secretion; response to drug; response to organic cyclic compound; triglyceride metabolic process IPR000542; Lipid metabolism; fatty acid beta-oxidation. "Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A)" CPT1A CPT1 Homo sapiens (Human) TR43180_c3_g1_i2 P52825 CPT2_MOUSE 2.00E-21 GO:0004095; GO:0006631; GO:0005743; GO:0005739; GO:0005730; GO:0006810 carnitine O-palmitoyltransferase activity; fatty acid metabolic process; mitochondrial inner membrane; mitochondrion; nucleolus; transport IPR000542; "Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II) (CPT II)" Cpt2 Cpt-2 Mus musculus (Mouse) TR43180_c3_g2_i1 P32796 CACP_YEAST 1.00E-23 GO:0004092; GO:0009437; GO:0006631; GO:0005743; GO:0005739; GO:0005777; GO:0006810 Itself; Q07732; Q02821 carnitine O-acetyltransferase activity; carnitine metabolic process; fatty acid metabolic process; mitochondrial inner membrane; mitochondrion; peroxisome; transport IPR000542; "Carnitine O-acetyltransferase, mitochondrial (Carnitine acetylase) (EC 2.3.1.7)" CAT2 CAT YCAT YML042W YM8054.01 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR43180_c3_g2_i2 P75448 Y114_MYCPN 1.00E-07 GO:0016746 "transferase activity, transferring acyl groups" IPR000542; Putative acetyltransferase MPN_114 (EC 2.3.1.-) MPN_114 C09_orf600 MP040 Mycoplasma pneumoniae (strain ATCC 29342 / M129) TR43180_c3_g2_i4 P50416 CPT1A_HUMAN 4.00E-50 GO:0004095; GO:0009437; GO:0006853; GO:0042755; GO:0006635; GO:0006006; GO:0031307; GO:0001676; GO:0005743; GO:0032000; GO:0051260; GO:0050796; GO:0042493; GO:0014070; GO:0006641 carnitine O-palmitoyltransferase activity; carnitine metabolic process; carnitine shuttle; eating behavior; fatty acid beta-oxidation; glucose metabolic process; integral to mitochondrial outer membrane; long-chain fatty acid metabolic process; mitochondrial inner membrane; positive regulation of fatty acid beta-oxidation; protein homooligomerization; regulation of insulin secretion; response to drug; response to organic cyclic compound; triglyceride metabolic process IPR000542; Lipid metabolism; fatty acid beta-oxidation. "Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A)" CPT1A CPT1 Homo sapiens (Human) TR43180_c3_g2_i5 P52826 CACP_COLLI 5.00E-35 GO:0004092; GO:0005783; GO:0006631; GO:0005743; GO:0005777; GO:0006810 carnitine O-acetyltransferase activity; endoplasmic reticulum; fatty acid metabolic process; mitochondrial inner membrane; peroxisome; transport IPR000542; Carnitine O-acetyltransferase (Carnitine acetylase) (EC 2.3.1.7) (Carnitine acetyltransferase) (CAT) (CrAT) CRAT Columba livia (Domestic pigeon) TR43183_c0_g1_i1 Q23551 UNC22_CAEEL 0 GO:0031672; GO:0005524; GO:0046872; GO:0004674 A band; ATP binding; metal ion binding; protein serine/threonine kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans TR43183_c0_g1_i2 Q23551 UNC22_CAEEL 0 GO:0031672; GO:0005524; GO:0046872; GO:0004674 A band; ATP binding; metal ion binding; protein serine/threonine kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans TR43183_c0_g1_i3 Q86TC9 MYPN_HUMAN 9.00E-17 GO:0031674; GO:0030018; GO:0015630; GO:0005634; GO:0045214 P20929 I band; Z disc; microtubule cytoskeleton; nucleus; sarcomere organization IPR007110; IPR013783; IPR013098; IPR003598; Myopalladin (145 kDa sarcomeric protein) MYPN MYOP Homo sapiens (Human) TR43183_c0_g1_i4 Q86TC9 MYPN_HUMAN 9.00E-17 GO:0031674; GO:0030018; GO:0015630; GO:0005634; GO:0045214 P20929 I band; Z disc; microtubule cytoskeleton; nucleus; sarcomere organization IPR007110; IPR013783; IPR013098; IPR003598; Myopalladin (145 kDa sarcomeric protein) MYPN MYOP Homo sapiens (Human) TR43183_c0_g1_i5 Q86TC9 MYPN_HUMAN 1.00E-16 GO:0031674; GO:0030018; GO:0015630; GO:0005634; GO:0045214 P20929 I band; Z disc; microtubule cytoskeleton; nucleus; sarcomere organization IPR007110; IPR013783; IPR013098; IPR003598; Myopalladin (145 kDa sarcomeric protein) MYPN MYOP Homo sapiens (Human) TR43183_c0_g2_i1 O01761 UNC89_CAEEL 6.00E-45 GO:0005524; GO:0031430; GO:0005089; GO:0005543; GO:0004672; GO:0035023; GO:0030241 ATP binding; M band; Rho guanyl-nucleotide exchange factor activity; phospholipid binding; protein kinase activity; regulation of Rho protein signal transduction; skeletal muscle myosin thick filament assembly IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR007850; IPR001452; Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans TR43183_c0_g2_i10 Q63198 CNTN1_RAT 4.00E-20 GO:0007219; GO:0031225; GO:0030246; GO:0007155; GO:0021549; GO:0031175; GO:0005886; GO:0010628; GO:0010976; GO:0010765 Notch signaling pathway; anchored to membrane; carbohydrate binding; cell adhesion; cerebellum development; neuron projection development; plasma membrane; positive regulation of gene expression; positive regulation of neuron projection development; positive regulation of sodium ion transport IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Contactin-1 (Neural cell surface protein F3) Cntn1 Rattus norvegicus (Rat) TR43183_c0_g2_i11 O01761 UNC89_CAEEL 7.00E-46 GO:0005524; GO:0031430; GO:0005089; GO:0005543; GO:0004672; GO:0035023; GO:0030241 ATP binding; M band; Rho guanyl-nucleotide exchange factor activity; phospholipid binding; protein kinase activity; regulation of Rho protein signal transduction; skeletal muscle myosin thick filament assembly IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR007850; IPR001452; Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans TR43183_c0_g2_i12 Q8WZ42 TITIN_HUMAN 1.00E-43 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR43183_c0_g2_i2 Q8WZ42 TITIN_HUMAN 1.00E-43 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR43183_c0_g2_i3 Q96RW7 HMCN1_HUMAN 6.00E-31 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR43183_c0_g2_i5 Q8WZ42 TITIN_HUMAN 5.00E-43 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR43183_c0_g2_i6 Q96RW7 HMCN1_HUMAN 1.00E-31 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR43183_c0_g2_i7 O01761 UNC89_CAEEL 5.00E-44 GO:0005524; GO:0031430; GO:0005089; GO:0005543; GO:0004672; GO:0035023; GO:0030241 ATP binding; M band; Rho guanyl-nucleotide exchange factor activity; phospholipid binding; protein kinase activity; regulation of Rho protein signal transduction; skeletal muscle myosin thick filament assembly IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR007850; IPR001452; Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans TR43183_c0_g2_i8 Q8WZ42 TITIN_HUMAN 6.00E-43 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR43183_c0_g2_i9 Q18066 DIM_CAEEL 8.00E-39 GO:0005737 cytoplasm IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Disorganized muscle protein 1 (2D-page protein spot 8) dim-1 C18A11.7/C18A11.8 Caenorhabditis elegans TR43184_c1_g1_i1 P24014 SLIT_DROME 1.00E-09 GO:0035385; GO:0071666; GO:0016199; GO:0005509; GO:0048813; GO:0007502; GO:0035050; GO:0007427; GO:0008347; GO:0008406; GO:0008201; GO:0050929; GO:0046331; GO:0008078; GO:0001764; GO:0003151; GO:0005886; GO:0022409; GO:0005578; GO:2000274; GO:0007432 "Roundabout signaling pathway; Slit-Robo signaling complex; axon midline choice point recognition; calcium ion binding; dendrite morphogenesis; digestive tract mesoderm development; embryonic heart tube development; epithelial cell migration, open tracheal system; glial cell migration; gonad development; heparin binding; induction of negative chemotaxis; lateral inhibition; mesodermal cell migration; neuron migration; outflow tract morphogenesis; plasma membrane; positive regulation of cell-cell adhesion; proteinaceous extracellular matrix; regulation of epithelial cell migration, open tracheal system; salivary gland boundary specification" IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; IPR026906; Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) TR43184_c1_g1_i2 P08953 TOLL_DROME 1.00E-16 GO:0033565; GO:0008063; GO:0019732; GO:0007155; GO:0019955; GO:0050830; GO:0005769; GO:0009897; GO:0007507; GO:0035172; GO:0030097; GO:0045087; GO:0016021; GO:0006963; GO:0006967; GO:0045610; GO:0007416; GO:0016201; GO:0004888; GO:0007352 Itself; Q7K105 ESCRT-0 complex; Toll signaling pathway; antifungal humoral response; cell adhesion; cytokine binding; defense response to Gram-positive bacterium; early endosome; external side of plasma membrane; heart development; hemocyte proliferation; hemopoiesis; innate immune response; integral to membrane; positive regulation of antibacterial peptide biosynthetic process; positive regulation of antifungal peptide biosynthetic process; regulation of hemocyte differentiation; synapse assembly; synaptic target inhibition; transmembrane signaling receptor activity; zygotic specification of dorsal/ventral axis IPR000483; IPR001611; IPR003591; IPR000372; IPR000157; Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) TR43184_c2_g2_i1 Q90YS3 RS2_ICTPU 9.00E-146 GO:0003723; GO:0015935; GO:0003735; GO:0006412 RNA binding; small ribosomal subunit; structural constituent of ribosome; translation IPR014720; IPR000851; IPR005324; IPR020568; IPR014721; IPR005711; IPR013810; IPR018192; 40S ribosomal protein S2 rps2 Ictalurus punctatus (Channel catfish) (Silurus punctatus) TR43185_c3_g2_i3 Q2Q1W2 LIN41_HUMAN 3.00E-17 GO:0000082; GO:0000932; GO:0008543; GO:0035198; GO:0010586; GO:0035278; GO:0001843; GO:0021915; GO:2000637; GO:0051865; GO:0060964; GO:2000177; GO:0072089; GO:0004842; GO:0008270 G1/S transition of mitotic cell cycle; cytoplasmic mRNA processing body; fibroblast growth factor receptor signaling pathway; miRNA binding; miRNA metabolic process; negative regulation of translation involved in gene silencing by miRNA; neural tube closure; neural tube development; positive regulation of gene silencing by miRNA; protein autoubiquitination; regulation of gene silencing by miRNA; regulation of neural precursor cell proliferation; stem cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Homo sapiens (Human) TR43185_c3_g2_i7 Q5BIM1 TRI45_BOVIN 2.00E-19 GO:0005737; GO:0005634; GO:0008270 cytoplasm; nucleus; zinc ion binding IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) TR43186_c1_g1_i2 Q6DD06 ZC3HF_XENLA 1.00E-89 GO:0005737; GO:0046872; GO:0005634 cytoplasm; metal ion binding; nucleus IPR000571; Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) zc3h15 dfrp1 Xenopus laevis (African clawed frog) TR43188_c2_g3_i1 P82916 RT17_BOVIN 7.00E-10 GO:0005739; GO:0019843; GO:0005840; GO:0003735; GO:0006412 mitochondrion; rRNA binding; ribosome; structural constituent of ribosome; translation IPR012340; IPR000266; "28S ribosomal protein S17, mitochondrial (MRP-S17) (S17mt)" MRPS17 RPMS17 Bos taurus (Bovine) TR4319_c0_g1_i1 P0C5E3 PALLD_RAT 6.00E-10 GO:0030018; GO:0044295; GO:0030054; GO:0071456; GO:0030175; GO:0031175; GO:0043025; GO:0002102; GO:0071803; GO:0001726; GO:0031529; GO:0001725; GO:0060707; GO:0042060 Z disc; axonal growth cone; cell junction; cellular response to hypoxia; filopodium; neuron projection development; neuronal cell body; podosome; positive regulation of podosome assembly; ruffle; ruffle organization; stress fiber; trophoblast giant cell differentiation; wound healing IPR007110; IPR013783; IPR013098; IPR003598; Palladin (Fragment) Palld Rattus norvegicus (Rat) TR43190_c2_g3_i4 P62255 UB2G1_RAT 9.00E-84 GO:0005524; GO:0070936; GO:0070534; GO:0006511; GO:0004842 ATP binding; protein K48-linked ubiquitination; protein K63-linked ubiquitination; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR000608; IPR023313; IPR016135; Protein modification; protein ubiquitination. "Ubiquitin-conjugating enzyme E2 G1 (EC 6.3.2.19) (E217K) (UBC7) (Ubiquitin carrier protein G1) (Ubiquitin-protein ligase G1) [Cleaved into: Ubiquitin-conjugating enzyme E2 G1, N-terminally processed]" Ube2g1 Ubc7 Ube2g Rattus norvegicus (Rat) TR43191_c1_g1_i1 O43295 SRGP3_HUMAN 8.00E-110 GO:0005096; GO:0005829; GO:0043547; GO:0051056; GO:0007264 GTPase activator activity; cytosol; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR001060; IPR008936; IPR000198; IPR001452; SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP) SRGAP3 ARHGAP14 KIAA0411 KIAA1156 MEGAP SRGAP2 Homo sapiens (Human) TR43191_c1_g2_i1 Q54FG5 GACJJ_DICDI 1.00E-17 GO:0005096; GO:0005737; GO:0005543; GO:0043547; GO:0007165 GTPase activator activity; cytoplasm; phospholipid binding; positive regulation of GTPase activity; signal transduction IPR011993; IPR001849; IPR008936; IPR000198; IPR001452; Rho GTPase-activating protein gacJJ (GTPase activating factor for raC protein JJ) gacJJ DDB_G0290873 Dictyostelium discoideum (Slime mold) TR43191_c1_g2_i10 Q7Z6B7 SRGP1_HUMAN 2.00E-61 GO:0005100; GO:0007266; GO:0007411; GO:0016477; GO:0005829; GO:0051056; GO:0007264 Rho GTPase activator activity; Rho protein signal transduction; axon guidance; cell migration; cytosol; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR001060; IPR008936; IPR000198; IPR001452; SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) SRGAP1 ARHGAP13 KIAA1304 Homo sapiens (Human) TR43191_c1_g2_i3 B0S6J3 SRGP2_DANRE 1.00E-61 GO:0030675; GO:0048365; GO:0051014; GO:0030054; GO:0005829; GO:0060996; GO:0044327; GO:0046847; GO:0030027; GO:2001223; GO:0048812; GO:0005634; GO:0045335; GO:0014069; GO:0045211; GO:0042803; GO:0007165 Rac GTPase activator activity; Rac GTPase binding; actin filament severing; cell junction; cytosol; dendritic spine development; dendritic spine head; filopodium assembly; lamellipodium; negative regulation of neuron migration; neuron projection morphogenesis; nucleus; phagocytic vesicle; postsynaptic density; postsynaptic membrane; protein homodimerization activity; signal transduction IPR001060; IPR008936; IPR000198; IPR001452; SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) srgap2 srgap2a si:dkey-85p17.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR43191_c1_g2_i4 Q7Z6B7 SRGP1_HUMAN 3.00E-67 GO:0005100; GO:0007266; GO:0007411; GO:0016477; GO:0005829; GO:0051056; GO:0007264 Rho GTPase activator activity; Rho protein signal transduction; axon guidance; cell migration; cytosol; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR001060; IPR008936; IPR000198; IPR001452; SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) SRGAP1 ARHGAP13 KIAA1304 Homo sapiens (Human) TR43191_c1_g2_i5 Q7Z6B7 SRGP1_HUMAN 2.00E-66 GO:0005100; GO:0007266; GO:0007411; GO:0016477; GO:0005829; GO:0051056; GO:0007264 Rho GTPase activator activity; Rho protein signal transduction; axon guidance; cell migration; cytosol; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR001060; IPR008936; IPR000198; IPR001452; SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) SRGAP1 ARHGAP13 KIAA1304 Homo sapiens (Human) TR43191_c1_g2_i6 Q9VX32 RG190_DROME 2.00E-08 GO:0005525; GO:0005096; GO:0007415; GO:0005622; GO:0016319; GO:0045792; GO:0043547; GO:0050770; GO:0007264 GTP binding; GTPase activator activity; defasciculation of motor neuron axon; intracellular; mushroom body development; negative regulation of cell size; positive regulation of GTPase activity; regulation of axonogenesis; small GTPase mediated signal transduction IPR027417; IPR008936; IPR000198; IPR001806; Rho GTPase-activating protein 190 (Rho GTPase-activating protein of 190 kDa) RhoGAPp190 CG32555 Drosophila melanogaster (Fruit fly) TR43191_c1_g2_i8 Q8AVG0 ABR_XENLA 2.00E-07 GO:0005096; GO:0005089; GO:0005622; GO:0035556; GO:0005543; GO:0043547; GO:0035023 GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; intracellular; intracellular signal transduction; phospholipid binding; positive regulation of GTPase activity; regulation of Rho protein signal transduction IPR000008; IPR000219; IPR001331; IPR011993; IPR001849; IPR008936; IPR000198; Active breakpoint cluster region-related protein abr Xenopus laevis (African clawed frog) TR43191_c1_g2_i9 Q3KRB8 RHGBB_HUMAN 8.00E-12 GO:0005096; GO:0005829; GO:0043547; GO:0051056; GO:0007264 GTPase activator activity; cytosol; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR008936; IPR000198; Rho GTPase-activating protein 11B (Rho-type GTPase-activating protein 11B) ARHGAP11B Homo sapiens (Human) TR43193_c1_g1_i1 Q6BEA2 PRS27_RAT 2.00E-31 GO:0005576; GO:0005886; GO:0006508; GO:0004252 extracellular region; plasma membrane; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Serine protease 27 (EC 3.4.21.-) (Marapsin) (Pancreasin) Prss27 Mpn Rattus norvegicus (Rat) TR43193_c1_g1_i2 Q9Y6M0 TEST_HUMAN 5.00E-33 GO:0031225; GO:0005737; GO:0005886; GO:0006508; GO:0004252; GO:0008236 P36952 anchored to membrane; cytoplasm; plasma membrane; proteolysis; serine-type endopeptidase activity; serine-type peptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Testisin (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP-1) (Serine protease 21) PRSS21 ESP1 TEST1 UNQ266/PRO303 Homo sapiens (Human) TR43193_c2_g1_i1 P16264 SPER_STRPU 2.00E-06 GO:0016021; GO:0005044 integral to membrane; scavenger receptor activity IPR001190; IPR017448; Egg peptide speract receptor Strongylocentrotus purpuratus (Purple sea urchin) TR43193_c2_g1_i2 Q0WYX8 MDGA1_CHICK 1.00E-21 GO:0046658; GO:0001764 anchored to plasma membrane; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 MDGA1 Gallus gallus (Chicken) TR43193_c2_g1_i3 Q63191 AEGP_RAT 4.00E-20 GO:0005768; GO:0016021; GO:0015031 endosome; integral to membrane; protein transport IPR008985; IPR023415; IPR002172; IPR000998; Apical endosomal glycoprotein (MAM domain-containing protein 4) Mamdc4 Aegp Rattus norvegicus (Rat) TR43193_c2_g4_i1 P98072 ENTK_BOVIN 3.00E-18 GO:0016021; GO:0006508; GO:0005044; GO:0004252 integral to membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity IPR008985; IPR000859; IPR023415; IPR002172; IPR000998; IPR011163; IPR001254; IPR018114; IPR001314; IPR000082; IPR001190; IPR017448; IPR009003; Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain] TMPRSS15 ENTK PRSS7 Bos taurus (Bovine) TR43193_c2_g4_i2 P57727 TMPS3_HUMAN 2.00E-10 GO:0006883; GO:0005789; GO:0016021; GO:0043025; GO:0006508; GO:0005044; GO:0007605; GO:0004252; GO:0017080 cellular sodium ion homeostasis; endoplasmic reticulum membrane; integral to membrane; neuronal cell body; proteolysis; scavenger receptor activity; sensory perception of sound; serine-type endopeptidase activity; sodium channel regulator activity IPR023415; IPR002172; IPR001254; IPR018114; IPR001314; IPR001190; IPR017448; IPR009003; Transmembrane protease serine 3 (EC 3.4.21.-) (Serine protease TADG-12) (Tumor-associated differentially-expressed gene 12 protein) TMPRSS3 ECHOS1 TADG12 UNQ323/PRO382 Homo sapiens (Human) TR43194_c1_g1_i1 Q4R7U0 TMC7_MACFA 4.00E-84 GO:0016021; GO:0006811 integral to membrane; ion transport IPR012496; Transmembrane channel-like protein 7 TMC7 QtsA-14390 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR43194_c1_g2_i1 O00418 EF2K_HUMAN 3.00E-106 GO:0005524; GO:0005509; GO:0005516; GO:0005829; GO:0004686; GO:0008286; GO:0046777; GO:0031952; GO:0008135; GO:0006414 "ATP binding; calcium ion binding; calmodulin binding; cytosol; elongation factor-2 kinase activity; insulin receptor signaling pathway; protein autophosphorylation; regulation of protein autophosphorylation; translation factor activity, nucleic acid binding; translational elongation" IPR017400; IPR011009; IPR004166; IPR006597; IPR011990; Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) EEF2K Homo sapiens (Human) TR43194_c1_g2_i10 O00418 EF2K_HUMAN 2.00E-106 GO:0005524; GO:0005509; GO:0005516; GO:0005829; GO:0004686; GO:0008286; GO:0046777; GO:0031952; GO:0008135; GO:0006414 "ATP binding; calcium ion binding; calmodulin binding; cytosol; elongation factor-2 kinase activity; insulin receptor signaling pathway; protein autophosphorylation; regulation of protein autophosphorylation; translation factor activity, nucleic acid binding; translational elongation" IPR017400; IPR011009; IPR004166; IPR006597; IPR011990; Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) EEF2K Homo sapiens (Human) TR43194_c1_g2_i3 O00418 EF2K_HUMAN 2.00E-106 GO:0005524; GO:0005509; GO:0005516; GO:0005829; GO:0004686; GO:0008286; GO:0046777; GO:0031952; GO:0008135; GO:0006414 "ATP binding; calcium ion binding; calmodulin binding; cytosol; elongation factor-2 kinase activity; insulin receptor signaling pathway; protein autophosphorylation; regulation of protein autophosphorylation; translation factor activity, nucleic acid binding; translational elongation" IPR017400; IPR011009; IPR004166; IPR006597; IPR011990; Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) EEF2K Homo sapiens (Human) TR43196_c3_g2_i1 Q174I2 PRIC1_AEDAE 1.00E-18 GO:0009948; GO:0001736; GO:0005886; GO:0008270 anterior/posterior axis specification; establishment of planar polarity; plasma membrane; zinc ion binding IPR010442; IPR001781; Protein prickle pk AAEL006891 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR43196_c3_g2_i2 O35115 FHL2_RAT 7.00E-88 GO:0031430; GO:0030018; GO:0015629; GO:0055014; GO:0005925; GO:0060347; GO:0043066; GO:0000122; GO:0005634; GO:0001649; GO:0009725; GO:0008134; GO:0006351; GO:0055015; GO:0008270 "M band; Z disc; actin cytoskeleton; atrial cardiac muscle cell development; focal adhesion; heart trabecula formation; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter; nucleus; osteoblast differentiation; response to hormone stimulus; transcription factor binding; transcription, DNA-dependent; ventricular cardiac muscle cell development; zinc ion binding" IPR001781; Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3) Fhl2 Dral Slim3 Rattus norvegicus (Rat) TR43197_c0_g1_i1 A4UTQ0 MAEL_PIG 8.00E-46 GO:0003677; GO:0043046; GO:0030154; GO:0031047; GO:0007126; GO:0007275; GO:0005634; GO:0071547; GO:0034587; GO:0007283 DNA binding; DNA methylation involved in gamete generation; cell differentiation; gene silencing by RNA; meiosis; multicellular organismal development; nucleus; piP-body; piRNA metabolic process; spermatogenesis IPR009071; IPR024970; Protein maelstrom homolog MAEL Sus scrofa (Pig) TR43198_c0_g1_i2 Q8AXB3 VGFR4_DANRE 4.00E-10 GO:0005524; GO:0048844; GO:0030154; GO:0035050; GO:0016021; GO:0005886; GO:0002040; GO:0030878; GO:0004714; GO:0007169 A4JYN2; Q8UVD6; A8BBB9; A4JYI8; A4JYQ2; Q6NW92; A8BBG3; A8BB40; A8BBE6; Q6P5M1; Q90Z69; A4JYE7; Q6NZ26 ATP binding; artery morphogenesis; cell differentiation; embryonic heart tube development; integral to membrane; plasma membrane; sprouting angiogenesis; thyroid gland development; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR001824; Vascular endothelial growth factor receptor kdr-like (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor-A) (Kinase insert domain receptor-like) (Protein-tyrosine kinase receptor flk-1) (Vascular endothelial growth factor receptor 4) (VEGFR-4) kdrl flk flk-1 flk1 flka kdr kdra vegfr2 vegfr4 vegr2 si:ch211-276g21.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR43198_c0_g2_i2 Q86PM4 FGFR_HYDVU 2.00E-07 GO:0005524; GO:0005007; GO:0016021; GO:0018108; GO:0008284 ATP binding; fibroblast growth factor-activated receptor activity; integral to membrane; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation IPR016248; IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor (EC 2.7.10.1) (Protein kringelchen) FGFR Hydra vulgaris (Hydra) (Hydra attenuata) TR43198_c0_g2_i3 Q6PDN3 MYLK_MOUSE 3.00E-41 GO:0005524; GO:0032154; GO:0005737; GO:0005856; GO:0030027; GO:0046872; GO:0004687; GO:0014820 Q9JMG9 ATP binding; cleavage furrow; cytoplasm; cytoskeleton; lamellipodium; metal ion binding; myosin light chain kinase activity; tonic smooth muscle contraction IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR020675; IPR000719; IPR017441; IPR002290; IPR008271; "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]" Mylk Mus musculus (Mouse) TR43198_c0_g2_i4 A8WGA3 LFN1L_DANRE 2.00E-06 GO:0030054; GO:0016021; GO:0045202 cell junction; integral to membrane; synapse IPR000483; IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeat and fibronectin type III domain-containing protein 1-like protein lrfn1l zgc:172282 Danio rerio (Zebrafish) (Brachydanio rerio) TR43198_c1_g1_i1 Q8WZ42 TITIN_HUMAN 0 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR43198_c1_g1_i3 Q8WZ42 TITIN_HUMAN 9.00E-112 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR43198_c1_g1_i4 P20273 CD22_HUMAN 1.00E-11 GO:0007155; GO:0009897; GO:0005887 P07948; P19174; P29350; P43405 cell adhesion; external side of plasma membrane; integral to plasma membrane IPR013162; IPR007110; IPR013783; IPR003599; IPR003598; IPR013151; B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) TR43202_c0_g1_i3 Q6YZE2 GSA_ORYSJ 6.00E-22 GO:0015995; GO:0009507; GO:0042286; GO:0006782; GO:0030170; GO:0008483 "chlorophyll biosynthetic process; chloroplast; glutamate-1-semialdehyde 2,1-aminomutase activity; protoporphyrinogen IX biosynthetic process; pyridoxal phosphate binding; transaminase activity" IPR004639; IPR005814; IPR015424; IPR015421; IPR015422; Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. Porphyrin-containing compound metabolism; chlorophyll biosynthesis. "Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic (GSA) (EC 5.4.3.8) (Glutamate-1-semialdehyde aminotransferase) (GSA-AT)" GSA Os08g0532200 LOC_Os08g41990 P0702E04.16 Oryza sativa subsp. japonica (Rice) TR43202_c0_g1_i4 Q9VW26 OAT_DROME 0 GO:0055129; GO:0005759; GO:0022008; GO:0006591; GO:0004587; GO:0030170 L-proline biosynthetic process; mitochondrial matrix; neurogenesis; ornithine metabolic process; ornithine-oxo-acid transaminase activity; pyridoxal phosphate binding IPR005814; IPR010164; IPR015424; IPR015421; IPR015422; Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1. "Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine--oxo-acid aminotransferase)" Oat CG8782 Drosophila melanogaster (Fruit fly) TR43203_c1_g1_i2 Q6ZBH9 NCKP1_ORYSJ 5.00E-53 IPR019137; Probable protein NAP1 (NAP of plants) (Nck-associated protein 1) (P125Nap1) NAP1 Os08g0544500 LOC_Os08g43130 P0623F08.25 Oryza sativa subsp. japonica (Rice) TR43203_c1_g1_i4 P55161 NCKP1_RAT 0 GO:0016021; GO:0031258 integral to membrane; lamellipodium membrane IPR019137; Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1) Nckap1 Hem2 Nap1 Rattus norvegicus (Rat) TR43203_c1_g1_i5 B0S6R1 NCKP1_DANRE 3.00E-35 GO:0016021; GO:0031258 integral to membrane; lamellipodium membrane IPR019137; Nck-associated protein 1 (NAP 1) nckap1 si:dkey-234n3.1 wu:fd05c01 Danio rerio (Zebrafish) (Brachydanio rerio) TR43204_c1_g1_i2 Q52KD8 EAF6_XENLA 1.00E-36 GO:0070776; GO:0035267; GO:0043968; GO:0044154; GO:0043983; GO:0043981; GO:0043982; GO:0005730; GO:0006355; GO:0006351 "MOZ/MORF histone acetyltransferase complex; NuA4 histone acetyltransferase complex; histone H2A acetylation; histone H3-K14 acetylation; histone H4-K12 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; nucleolus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR015418; Chromatin modification-related protein MEAF6 (MYST/Esa1-associated factor 6) (Esa1-associated factor 6 homolog) (Protein EAF6 homolog) meaf6 Xenopus laevis (African clawed frog) TR43205_c0_g2_i1 Q4PSY4 GOLS7_ARATH 2.00E-13 GO:0005737; GO:0006012; GO:0047216; GO:0046872 cytoplasm; galactose metabolic process; inositol 3-alpha-galactosyltransferase activity; metal ion binding IPR002495; Galactinol synthase 7 (AtGolS7) (GolS-7) (EC 2.4.1.123) GOLS7 At1g60450 T13D8.32 Arabidopsis thaliana (Mouse-ear cress) TR43205_c0_g2_i2 P13280 GLYG_RABIT 1.00E-115 GO:0005978; GO:0008466; GO:0046872 glycogen biosynthetic process; glycogenin glucosyltransferase activity; metal ion binding IPR002495; Glycan biosynthesis; glycogen biosynthesis. Glycogenin-1 (GN-1) (GN1) (EC 2.4.1.186) GYG1 GYG Oryctolagus cuniculus (Rabbit) TR43206_c0_g1_i1 Q6DFV3 RHG21_MOUSE 1.00E-99 GO:0005096; GO:0000139; GO:0030054; GO:0030659; GO:0005856; GO:0005543; GO:0043547; GO:0007165 GTPase activator activity; Golgi membrane; cell junction; cytoplasmic vesicle membrane; cytoskeleton; phospholipid binding; positive regulation of GTPase activity; signal transduction IPR001478; IPR011993; IPR001849; IPR008936; IPR000198; Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21) Arhgap21 Arhgap10 Kiaa1424 Mus musculus (Mouse) TR43206_c0_g1_i3 O60759 CYTIP_HUMAN 3.00E-06 GO:0005938; GO:0005769; GO:0030155 Q15438 cell cortex; early endosome; regulation of cell adhesion IPR001478; Cytohesin-interacting protein (Cytohesin binder and regulator) (CYBR) (Cytohesin-associated scaffolding protein) (CASP) (Cytohesin-binding protein HE) (Cbp HE) (Pleckstrin homology Sec7 and coiled-coil domains-binding protein) CYTIP PSCDBP Homo sapiens (Human) TR43207_c1_g1_i3 Q12923 PTN13_HUMAN 1.00E-60 GO:0005737; GO:0005856; GO:0030027; GO:0005634; GO:0005886; GO:0004725 P25445; Q9BUL8; Q8TEU7 cytoplasm; cytoskeleton; lamellipodium; nucleus; plasma membrane; protein tyrosine phosphatase activity IPR019749; IPR019750; IPR014352; IPR019748; IPR000299; IPR018979; IPR018980; IPR011019; IPR001478; IPR011993; IPR000387; IPR012153; IPR000242; Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) PTPN13 PNP1 PTP1E PTPL1 Homo sapiens (Human) TR43207_c1_g1_i4 Q12923 PTN13_HUMAN 1.00E-50 GO:0005737; GO:0005856; GO:0030027; GO:0005634; GO:0005886; GO:0004725 P25445; Q9BUL8; Q8TEU7 cytoplasm; cytoskeleton; lamellipodium; nucleus; plasma membrane; protein tyrosine phosphatase activity IPR019749; IPR019750; IPR014352; IPR019748; IPR000299; IPR018979; IPR018980; IPR011019; IPR001478; IPR011993; IPR000387; IPR012153; IPR000242; Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) PTPN13 PNP1 PTP1E PTPL1 Homo sapiens (Human) TR43208_c4_g1_i1 P91931 DCAM_DROME 5.00E-100 GO:0006557; GO:0004014; GO:0050829; GO:0008295; GO:0006597 S-adenosylmethioninamine biosynthetic process; adenosylmethionine decarboxylase activity; defense response to Gram-negative bacterium; spermidine biosynthetic process; spermine biosynthetic process IPR001985; IPR018167; IPR016067; IPR018166; Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1. S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain] SamDC CG5029 Drosophila melanogaster (Fruit fly) TR43209_c3_g3_i1 Q96RQ3 MCCA_HUMAN 3.00E-150 GO:0005524; GO:0009374; GO:0004075; GO:0006768; GO:0005829; GO:0006552; GO:0046872; GO:0004485; GO:0005743; GO:0005759 ATP binding; biotin binding; biotin carboxylase activity; biotin metabolic process; cytosol; leucine catabolic process; metal ion binding; methylcrotonoyl-CoA carboxylase activity; mitochondrial inner membrane; mitochondrial matrix IPR011761; IPR013815; IPR013816; IPR001882; IPR011764; IPR005482; IPR000089; IPR005481; IPR005479; IPR016185; IPR011054; IPR011053; Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3. "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha)" MCCC1 MCCA Homo sapiens (Human) TR43209_c3_g3_i2 Q612F5 PCCA_CAEBR 0 GO:0005524; GO:0004075; GO:0046872; GO:0005759; GO:0004658 ATP binding; biotin carboxylase activity; metal ion binding; mitochondrial matrix; propionyl-CoA carboxylase activity IPR011761; IPR013815; IPR013816; IPR001882; IPR011764; IPR005482; IPR000089; IPR005481; IPR005479; IPR016185; IPR011054; IPR011053; Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3. "Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)" pcca-1 CBG16755 Caenorhabditis briggsae TR43211_c1_g2_i1 Q09349 UBE4_CAEEL 1.00E-83 GO:0005737; GO:0005634; GO:0051865; GO:0000209; GO:0000151; GO:0006511; GO:0004842; GO:0034450 cytoplasm; nucleus; protein autoubiquitination; protein polyubiquitination; ubiquitin ligase complex; ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; ubiquitin-ubiquitin ligase activity IPR019474; IPR003613; IPR013083; Probable ubiquitin conjugation factor E4 ufd-2 T05H10.5 Caenorhabditis elegans TR43211_c1_g2_i2 Q9ES00 UBE4B_MOUSE 0 GO:0005737; GO:0008626; GO:0006457; GO:0042787; GO:0009411; GO:0000151; GO:0034450; GO:0051082 cytoplasm; granzyme-mediated apoptotic signaling pathway; protein folding; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; response to UV; ubiquitin ligase complex; ubiquitin-ubiquitin ligase activity; unfolded protein binding IPR019474; IPR003613; IPR013083; Ubiquitin conjugation factor E4 B (Ubiquitin fusion degradation protein 2) (Ufd2a) Ube4b Ufd2 Mus musculus (Mouse) TR43211_c1_g2_i4 Q9ES00 UBE4B_MOUSE 0 GO:0005737; GO:0008626; GO:0006457; GO:0042787; GO:0009411; GO:0000151; GO:0034450; GO:0051082 cytoplasm; granzyme-mediated apoptotic signaling pathway; protein folding; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; response to UV; ubiquitin ligase complex; ubiquitin-ubiquitin ligase activity; unfolded protein binding IPR019474; IPR003613; IPR013083; Ubiquitin conjugation factor E4 B (Ubiquitin fusion degradation protein 2) (Ufd2a) Ube4b Ufd2 Mus musculus (Mouse) TR43213_c2_g2_i1 O14976 GAK_HUMAN 7.00E-165 GO:0005524; GO:0005794; GO:0007049; GO:0005925; GO:0048471; GO:0004674 Q9NQ11 ATP binding; Golgi apparatus; cell cycle; focal adhesion; perinuclear region of cytoplasm; protein serine/threonine kinase activity IPR000008; IPR001623; IPR011009; IPR014019; IPR000719; IPR008271; IPR014020; Cyclin-G-associated kinase (EC 2.7.11.1) GAK Homo sapiens (Human) TR43213_c2_g3_i1 Q27974 AUXI_BOVIN 5.00E-107 GO:0035335; GO:0004725 peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR000008; IPR001623; IPR014019; IPR014020; Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6) DNAJC6 Bos taurus (Bovine) TR43213_c2_g3_i2 Q80TZ3 AUXI_MOUSE 1.00E-108 GO:0035335; GO:0004725 peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR000008; IPR001623; IPR014019; IPR014020; Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6) Dnajc6 Kiaa0473 Mus musculus (Mouse) TR43213_c2_g3_i3 O14976 GAK_HUMAN 9.00E-136 GO:0005524; GO:0005794; GO:0007049; GO:0005925; GO:0048471; GO:0004674 Q9NQ11 ATP binding; Golgi apparatus; cell cycle; focal adhesion; perinuclear region of cytoplasm; protein serine/threonine kinase activity IPR000008; IPR001623; IPR011009; IPR014019; IPR000719; IPR008271; IPR014020; Cyclin-G-associated kinase (EC 2.7.11.1) GAK Homo sapiens (Human) TR43214_c2_g2_i1 P23128 DDX6_DROME 0 GO:0005524; GO:0004004; GO:0043186; GO:0003723; GO:0000932; GO:0033962; GO:0035195; GO:0005875; GO:0007095 Q9VMA3 ATP binding; ATP-dependent RNA helicase activity; P granule; RNA binding; cytoplasmic mRNA processing body; cytoplasmic mRNA processing body assembly; gene silencing by miRNA; microtubule associated complex; mitotic G2 DNA damage checkpoint IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; Putative ATP-dependent RNA helicase me31b (EC 3.6.4.13) (Maternal expression at 31B) me31B CG4916 Drosophila melanogaster (Fruit fly) TR43215_c0_g1_i1 A8MU46 SMTL1_HUMAN 5.00E-44 GO:0031674; GO:0031430; GO:0043292; GO:0045908; GO:0005634; GO:0045907 I band; M band; contractile fiber; negative regulation of vasodilation; nucleus; positive regulation of vasoconstriction IPR001715; Smoothelin-like protein 1 SMTNL1 Homo sapiens (Human) TR43216_c4_g1_i1 Q8BX70 VP13C_MOUSE 0 IPR015412; IPR026847; IPR026854; IPR009543; Vacuolar protein sorting-associated protein 13C Vps13c Kiaa3021 Mus musculus (Mouse) TR43217_c3_g1_i2 Q9H2M9 RBGPR_HUMAN 2.00E-111 GO:0005096; GO:0005737; GO:0006886; GO:0005886; GO:0046982 O75365 GTPase activator activity; cytoplasm; intracellular protein transport; plasma membrane; protein heterodimerization activity IPR026059; Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) RAB3GAP2 KIAA0839 Homo sapiens (Human) TR43217_c3_g3_i3 Q9H2M9 RBGPR_HUMAN 1.00E-46 GO:0005096; GO:0005737; GO:0006886; GO:0005886; GO:0046982 O75365 GTPase activator activity; cytoplasm; intracellular protein transport; plasma membrane; protein heterodimerization activity IPR026059; Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) RAB3GAP2 KIAA0839 Homo sapiens (Human) TR43218_c4_g3_i1 Q5RBR8 IF4H_PONAB 9.00E-28 GO:0000166; GO:0048471; GO:0003743 nucleotide binding; perinuclear region of cytoplasm; translation initiation factor activity IPR012677; IPR000504; Eukaryotic translation initiation factor 4H (eIF-4H) EIF4H Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR43221_c2_g2_i1 Q9Y426 CU025_HUMAN 7.00E-17 GO:0005829; GO:0005576; GO:0005634 cytosol; extracellular region; nucleus IPR000008; C2 domain-containing protein 2 C2CD2 C21orf25 C21orf258 Homo sapiens (Human) TR43222_c2_g3_i2 Q9Y4F5 K0284_HUMAN 6.00E-21 GO:0005737; GO:0005874 cytoplasm; microtubule IPR000253; IPR008984; Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) CEP170B FAM68C KIAA0284 Homo sapiens (Human) TR43223_c1_g2_i1 P68827 NAGPA_BOVIN 4.00E-09 GO:0032580; GO:0003944; GO:0016021; GO:0006486 Golgi cisterna membrane; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity; integral to membrane; protein glycosylation IPR018711; IPR000742; IPR013032; Protein modification; protein glycosylation. N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) (Mannose 6-phosphate-uncovering enzyme) (Phosphodiester alpha-GlcNAcase) NAGPA Bos taurus (Bovine) TR43226_c3_g1_i1 C0HBB2 NCUG1_SALSA 2.00E-39 GO:0016021; GO:0005765; GO:0005764 integral to membrane; lysosomal membrane; lysosome Lysosomal protein NCU-G1 Salmo salar (Atlantic salmon) TR43226_c3_g1_i2 A8WH34 NCG1B_XENLA 4.00E-36 GO:0016021; GO:0005765; GO:0005764 integral to membrane; lysosomal membrane; lysosome Lysosomal protein NCU-G1-B Xenopus laevis (African clawed frog) TR43227_c0_g2_i3 P08548 LIN1_NYCCO 1.00E-33 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR43227_c1_g2_i1 P14381 YTX2_XENLA 4.00E-13 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR43227_c2_g1_i3 P08548 LIN1_NYCCO 2.00E-86 GO:0003723; GO:0006278; GO:0003964; GO:0046872 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding IPR013544; IPR005135; IPR000477; LINE-1 reverse transcriptase homolog (EC 2.7.7.49) Nycticebus coucang (Slow loris) TR43229_c2_g1_i1 O75592 MYCB2_HUMAN 0 GO:0030424; GO:0021785; GO:0021952; GO:0015630; GO:0005634; GO:0051493; GO:0032880; GO:0006355; GO:0006351; GO:0004842; GO:0008270 Q99IB8 "axon; branchiomotor neuron axon guidance; central nervous system projection neuron axonogenesis; microtubule cytoskeleton; nucleus; regulation of cytoskeleton organization; regulation of protein localization; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR004939; IPR017868; IPR008979; IPR027047; IPR013783; IPR014756; IPR012983; IPR009091; IPR000408; IPR003646; IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc) MYCBP2 KIAA0916 PAM Homo sapiens (Human) TR43229_c2_g1_i2 Q17551 RPM1_CAEEL 2.00E-148 GO:0030424; GO:0010171; GO:0040011; GO:0043409; GO:0031594; GO:0005634; GO:0018991; GO:0036062; GO:0031647; GO:0050807; GO:0006355; GO:0006351; GO:0004842; GO:0008270 "axon; body morphogenesis; locomotion; negative regulation of MAPK cascade; neuromuscular junction; nucleus; oviposition; presynaptic periactive zone; regulation of protein stability; regulation of synapse organization; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR004939; IPR008979; IPR027047; IPR012983; IPR009091; IPR000408; IPR000315; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase rpm-1 (EC 6.3.2.-) (Pam/highwire/rpm-1 protein) (Regulator of presynaptic morphology protein 1) (Synapse defective protein 3) rpm-1 syd-3 C01B7.6 Caenorhabditis elegans TR43229_c2_g1_i3 Q7TPH6 MYCB2_MOUSE 2.00E-53 GO:0030424; GO:0021785; GO:0021952; GO:0015630; GO:0042177; GO:0005634; GO:0051493; GO:0032880; GO:0006355; GO:0006351; GO:0004842; GO:0008270 Q63633 "axon; branchiomotor neuron axon guidance; central nervous system projection neuron axonogenesis; microtubule cytoskeleton; negative regulation of protein catabolic process; nucleus; regulation of cytoskeleton organization; regulation of protein localization; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR004939; IPR017868; IPR008979; IPR027047; IPR013783; IPR014756; IPR012983; IPR009091; IPR000408; IPR003646; IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc) Mycbp2 Pam Phr1 Mus musculus (Mouse) TR43234_c1_g1_i2 Q8WNR0 COPT1_PIG 5.00E-38 GO:0005375; GO:0016021; GO:0005886 copper ion transmembrane transporter activity; integral to membrane; plasma membrane IPR007274; High affinity copper uptake protein 1 (Copper transporter 1) (CTR1) (Solute carrier family 31 member 1) SLC31A1 CTR1 Sus scrofa (Pig) TR43236_c1_g1_i1 Q8K009 AL1L2_MOUSE 0 GO:0009258; GO:0009058; GO:0016155; GO:0016742; GO:0032259; GO:0008168; GO:0005739; GO:0006730; GO:0016620 "10-formyltetrahydrofolate catabolic process; biosynthetic process; formyltetrahydrofolate dehydrogenase activity; hydroxymethyl-, formyl- and related transferase activity; methylation; methyltransferase activity; mitochondrion; one-carbon metabolic process; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" IPR011407; IPR009081; IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR005793; IPR002376; IPR011034; IPR001555; IPR006162; Mitochondrial 10-formyltetrahydrofolate dehydrogenase (Mitochondrial 10-FTHFDH) (mtFDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L2) Aldh1l2 Mus musculus (Mouse) TR43236_c1_g1_i2 Q28399 ALDH1_ELEED 7.00E-153 GO:0004029; GO:0005737; GO:0006068 aldehyde dehydrogenase (NAD) activity; cytoplasm; ethanol catabolic process IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. "Aldehyde dehydrogenase, cytosolic 1 (EC 1.2.1.3) (ALDH class 1) (ETA-crystallin)" ALDH1 Elephantulus edwardii (Cape long-eared elephant shrew) TR43236_c1_g1_i3 A3M365 BETB_ACIBT 1.00E-121 GO:0008802; GO:0019285; GO:0046872 betaine-aldehyde dehydrogenase activity; glycine betaine biosynthetic process from choline; metal ion binding IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR011264; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. NAD/NADP-dependent betaine aldehyde dehydrogenase (BADH) (EC 1.2.1.8) betB A1S_0927 Acinetobacter baumannii (strain ATCC 17978 / NCDC KC 755) TR43236_c1_g1_i4 Q8K009 AL1L2_MOUSE 0 GO:0009258; GO:0009058; GO:0016155; GO:0016742; GO:0032259; GO:0008168; GO:0005739; GO:0006730; GO:0016620 "10-formyltetrahydrofolate catabolic process; biosynthetic process; formyltetrahydrofolate dehydrogenase activity; hydroxymethyl-, formyl- and related transferase activity; methylation; methyltransferase activity; mitochondrion; one-carbon metabolic process; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" IPR011407; IPR009081; IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR005793; IPR002376; IPR011034; IPR001555; IPR006162; Mitochondrial 10-formyltetrahydrofolate dehydrogenase (Mitochondrial 10-FTHFDH) (mtFDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L2) Aldh1l2 Mus musculus (Mouse) TR43236_c1_g1_i5 Q8K009 AL1L2_MOUSE 0 GO:0009258; GO:0009058; GO:0016155; GO:0016742; GO:0032259; GO:0008168; GO:0005739; GO:0006730; GO:0016620 "10-formyltetrahydrofolate catabolic process; biosynthetic process; formyltetrahydrofolate dehydrogenase activity; hydroxymethyl-, formyl- and related transferase activity; methylation; methyltransferase activity; mitochondrion; one-carbon metabolic process; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" IPR011407; IPR009081; IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR005793; IPR002376; IPR011034; IPR001555; IPR006162; Mitochondrial 10-formyltetrahydrofolate dehydrogenase (Mitochondrial 10-FTHFDH) (mtFDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L2) Aldh1l2 Mus musculus (Mouse) TR43237_c0_g1_i2 Q07130 UGPA_BOVIN 0 GO:0003983; GO:0005737; GO:0046872 UTP:glucose-1-phosphate uridylyltransferase activity; cytoplasm; metal ion binding IPR002618; IPR016267; UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) UGP2 Bos taurus (Bovine) TR43237_c0_g1_i4 Q07130 UGPA_BOVIN 0 GO:0003983; GO:0005737; GO:0046872 UTP:glucose-1-phosphate uridylyltransferase activity; cytoplasm; metal ion binding IPR002618; IPR016267; UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) UGP2 Bos taurus (Bovine) TR43238_c1_g1_i1 A2ASS6 TITIN_MOUSE 0 GO:0005524; GO:0031430; GO:0030018; GO:0007512; GO:0055003; GO:0043056; GO:0003007; GO:0001701; GO:0046872; GO:0006936; GO:0005859; GO:0005634; GO:0018108; GO:0004674; GO:0004713; GO:1901897; GO:0045214; GO:0001756; GO:0005200 ATP binding; M band; Z disc; adult heart development; cardiac myofibril assembly; forward locomotion; heart morphogenesis; in utero embryonic development; metal ion binding; muscle contraction; muscle myosin complex; nucleus; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of relaxation of cardiac muscle; sarcomere organization; somitogenesis; structural constituent of cytoskeleton IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) TR43238_c1_g1_i2 Q8N9C0 IGS22_HUMAN 5.00E-25 IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; Immunoglobulin superfamily member 22 (IgSF22) IGSF22 Homo sapiens (Human) TR43238_c1_g1_i3 Q80YX1 TENA_MOUSE 2.00E-07 GO:0005604; GO:0007155; GO:0005615; GO:0005614; GO:0060739; GO:0007528; GO:0014012; GO:0008284; GO:0010628; GO:0060740; GO:0045545 basement membrane; cell adhesion; extracellular space; interstitial matrix; mesenchymal-epithelial cell signaling involved in prostate gland development; neuromuscular junction development; peripheral nervous system axon regeneration; positive regulation of cell proliferation; positive regulation of gene expression; prostate gland epithelium morphogenesis; syndecan binding IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin (TN) (Hexabrachion) (Tenascin-C) (TN-C) Tnc Hxb Mus musculus (Mouse) TR43241_c4_g2_i1 Q8K1C7 MOT14_MOUSE 5.00E-35 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) Slc16a14 Mct14 Mus musculus (Mouse) TR43241_c4_g2_i2 Q8K1C7 MOT14_MOUSE 5.00E-35 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) Slc16a14 Mct14 Mus musculus (Mouse) TR43242_c1_g1_i1 Q8QFX1 RIMB2_CHICK 9.00E-13 GO:0030054; GO:0010923; GO:0005886; GO:0045202 cell junction; negative regulation of phosphatase activity; plasma membrane; synapse IPR003961; IPR013783; IPR011511; IPR001452; RIMS-binding protein 2 (RIM-BP2) RIMBP2 RBP2 Gallus gallus (Chicken) TR43244_c3_g2_i3 Q9ERE4 GOLP3_RAT 5.00E-117 GO:0031985; GO:0032580; GO:0007030; GO:0043001; GO:0048194; GO:0060352; GO:0008283; GO:0005829; GO:0005768; GO:0010467; GO:0009101; GO:0030032; GO:0050901; GO:0005758; GO:0005739; GO:0070273; GO:0005886; GO:0032008; GO:0050714; GO:0045053; GO:0009306; GO:0010821; GO:0005802 Golgi cisterna; Golgi cisterna membrane; Golgi organization; Golgi to plasma membrane protein transport; Golgi vesicle budding; cell adhesion molecule production; cell proliferation; cytosol; endosome; gene expression; glycoprotein biosynthetic process; lamellipodium assembly; leukocyte tethering or rolling; mitochondrial intermembrane space; mitochondrion; phosphatidylinositol-4-phosphate binding; plasma membrane; positive regulation of TOR signaling cascade; positive regulation of protein secretion; protein retention in Golgi apparatus; protein secretion; regulation of mitochondrion organization; trans-Golgi network IPR008628; Golgi phosphoprotein 3 (Coat protein GPP34) (Trans-Golgi protein GMx33) Golph3 Gmx33 Gpp34 Rattus norvegicus (Rat) TR43244_c3_g2_i5 Q9ERE4 GOLP3_RAT 9.00E-116 GO:0031985; GO:0032580; GO:0007030; GO:0043001; GO:0048194; GO:0060352; GO:0008283; GO:0005829; GO:0005768; GO:0010467; GO:0009101; GO:0030032; GO:0050901; GO:0005758; GO:0005739; GO:0070273; GO:0005886; GO:0032008; GO:0050714; GO:0045053; GO:0009306; GO:0010821; GO:0005802 Golgi cisterna; Golgi cisterna membrane; Golgi organization; Golgi to plasma membrane protein transport; Golgi vesicle budding; cell adhesion molecule production; cell proliferation; cytosol; endosome; gene expression; glycoprotein biosynthetic process; lamellipodium assembly; leukocyte tethering or rolling; mitochondrial intermembrane space; mitochondrion; phosphatidylinositol-4-phosphate binding; plasma membrane; positive regulation of TOR signaling cascade; positive regulation of protein secretion; protein retention in Golgi apparatus; protein secretion; regulation of mitochondrion organization; trans-Golgi network IPR008628; Golgi phosphoprotein 3 (Coat protein GPP34) (Trans-Golgi protein GMx33) Golph3 Gmx33 Gpp34 Rattus norvegicus (Rat) TR43245_c2_g1_i1 E2QUI9 NNRD_CANFA 2.00E-110 GO:0005524; GO:0047453; GO:0005739 ATP binding; ATP-dependent NAD(P)H-hydrate dehydratase activity; mitochondrion IPR026599; IPR000631; ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX dehydratase) (Carbohydrate kinase domain-containing protein) CARKD Canis familiaris (Dog) (Canis lupus familiaris) TR43245_c2_g1_i2 A9RY03 NNRD_PHYPA 1.00E-60 GO:0005524; GO:0047453; GO:0009507 ATP binding; ATP-dependent NAD(P)H-hydrate dehydratase activity; chloroplast IPR026599; IPR000631; ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX dehydratase) PHYPADRAFT_121160 Physcomitrella patens subsp. patens (Moss) TR43245_c2_g1_i3 Q9KMX5 NNR_VIBCH 1.00E-19 GO:0005524; GO:0016853; GO:0016829; GO:0046872 ATP binding; isomerase activity; lyase activity; metal ion binding IPR017953; IPR026599; IPR026600; IPR000631; IPR004443; Bifunctional NAD(P)H-hydrate repair enzyme Nnr (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)] nnr VC_A0191 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) TR43245_c2_g3_i1 Q9HC56 PCDH9_HUMAN 2.00E-110 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR013164; IPR013585; Protocadherin-9 PCDH9 Homo sapiens (Human) TR43247_c0_g1_i1 Q17N71 CLU_AEDAE 1.00E-115 GO:0005737; GO:0048312 cytoplasm; intracellular distribution of mitochondria IPR027523; IPR025697; IPR028275; IPR023231; IPR011990; Clustered mitochondria protein homolog AAEL000794 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR43247_c1_g1_i1 B0W2S0 CLU_CULQU 6.00E-166 GO:0005737; GO:0048312 cytoplasm; intracellular distribution of mitochondria IPR027523; IPR025697; IPR028275; IPR007967; IPR023231; IPR011990; Clustered mitochondria protein homolog CPIJ001445 Culex quinquefasciatus (Southern house mosquito) (Culex pungens) TR43247_c1_g1_i2 Q6CE38 CLU_YARLI 1.00E-09 GO:0005737; GO:0048312 cytoplasm; intracellular distribution of mitochondria IPR027523; IPR025697; IPR028275; IPR023231; IPR011990; Clustered mitochondria protein homolog (Protein TIF31 homolog) CLU1 TIF31 YALI0B18810g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) TR43247_c3_g1_i1 Q0IHW8 CLU_XENTR 0 GO:0005737; GO:0048312 cytoplasm; intracellular distribution of mitochondria IPR027523; IPR025697; IPR028275; IPR023231; IPR011990; Clustered mitochondria protein homolog cluh Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR43248_c2_g4_i1 P10079 FBP1_STRPU 7.00E-115 GO:0032579; GO:0005509; GO:0016023; GO:0005615 apical lamina of hyaline layer; calcium ion binding; cytoplasmic membrane-bounded vesicle; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) TR43248_c2_g4_i2 Q9QYE5 JAG2_MOUSE 2.00E-80 GO:0007219; GO:0009912; GO:0005509; GO:0001709; GO:1990134; GO:0042492; GO:0008083; GO:0001701; GO:0005887; GO:0016331; GO:0042475; GO:0030155; GO:0042127; GO:0003016; GO:0007605; GO:0001501; GO:0007283; GO:0045061 Notch signaling pathway; auditory receptor cell fate commitment; calcium ion binding; cell fate determination; epithelial cell apoptotic process involved in palatal shelf morphogenesis; gamma-delta T cell differentiation; growth factor activity; in utero embryonic development; integral to plasma membrane; morphogenesis of embryonic epithelium; odontogenesis of dentin-containing tooth; regulation of cell adhesion; regulation of cell proliferation; respiratory system process; sensory perception of sound; skeletal system development; spermatogenesis; thymic T cell selection IPR001774; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR026219; IPR011651; IPR001007; Protein jagged-2 (Jagged2) Jag2 Mus musculus (Mouse) TR43248_c2_g4_i3 P07207 NOTCH_DROME 1.00E-100 GO:0005796; GO:0061382; GO:0007219; GO:0048052; GO:0007464; GO:0045466; GO:0045463; GO:0007460; GO:0007015; GO:0005912; GO:0008356; GO:0007298; GO:0005509; GO:0009986; GO:0008407; GO:0003682; GO:0042676; GO:0046667; GO:0005829; GO:0008340; GO:0046843; GO:0007391; GO:0007451; GO:0007398; GO:0035165; GO:0005788; GO:0005768; GO:0061331; GO:0035153; GO:0035214; GO:0007440; GO:0060288; GO:0030718; GO:0030708; GO:0007403; GO:0008347; GO:0035172; GO:0007157; GO:0007446; GO:0016348; GO:0048803; GO:0008587; GO:0007474; GO:0016021; GO:0035171; GO:0046331; GO:0007616; GO:0035170; GO:0007498; GO:0008045; GO:0007521; GO:0046329; GO:0045316; GO:0035157; GO:0050768; GO:0035155; GO:0000122; GO:0007400; GO:0005654; GO:0007314; GO:0030720; GO:0030713; GO:0007422; GO:1900087; GO:0045747; GO:0008284; GO:0045944; GO:0043234; GO:0045468; GO:0042686; GO:0042689; GO:0051489; GO:0040008; GO:0009608; GO:0016330; GO:0007519; GO:0035003; GO:0006351; GO:0004888; GO:0007419; GO:0048190; GO:0007473 Q24279; P10041; P28159 "Golgi lumen; Malpighian tubule tip cell differentiation; Notch signaling pathway; R1/R6 cell differentiation; R3/R4 cell fate commitment; R7 cell differentiation; R8 cell development; R8 cell fate commitment; actin filament organization; adherens junction; asymmetric cell division; border follicle cell migration; calcium ion binding; cell surface; chaeta morphogenesis; chromatin binding; compound eye cone cell fate commitment; compound eye retinal cell programmed cell death; cytosol; determination of adult lifespan; dorsal appendage formation; dorsal closure; dorsal/ventral lineage restriction, imaginal disc; ectoderm development; embryonic crystal cell differentiation; endoplasmic reticulum lumen; endosome; epithelial cell proliferation involved in Malpighian tubule morphogenesis; epithelial cell type specification, open tracheal system; eye-antennal disc development; foregut morphogenesis; formation of a compartment boundary; germ-line stem cell maintenance; germarium-derived female germ-line cyst encapsulation; glial cell fate determination; glial cell migration; hemocyte proliferation; heterophilic cell-cell adhesion; imaginal disc growth; imaginal disc-derived leg joint morphogenesis; imaginal disc-derived male genitalia morphogenesis; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein specification; integral to membrane; lamellocyte differentiation; lateral inhibition; long-term memory; lymph gland crystal cell differentiation; mesoderm development; motor neuron axon guidance; muscle cell fate determination; negative regulation of JNK cascade; negative regulation of compound eye photoreceptor development; negative regulation of fusion cell fate specification; negative regulation of neurogenesis; negative regulation of terminal cell fate specification, open tracheal system; negative regulation of transcription from RNA polymerase II promoter; neuroblast fate determination; nucleoplasm; oocyte anterior/posterior axis specification; oocyte localization involved in germarium-derived egg chamber formation; ovarian follicle cell stalk formation; peripheral nervous system development; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of Notch signaling pathway; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; protein complex; regulation of R8 cell spacing in compound eye; regulation of cardioblast cell fate specification; regulation of crystal cell differentiation; regulation of filopodium assembly; regulation of growth; response to symbiont; second mitotic wave involved in compound eye morphogenesis; skeletal muscle tissue development; subapical complex; transcription, DNA-dependent; transmembrane signaling receptor activity; ventral cord development; wing disc dorsal/ventral pattern formation; wing disc proximal/distal pattern formation" IPR002110; IPR020683; IPR024600; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR008297; IPR000800; IPR010660; IPR011656; Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) TR43248_c2_g4_i4 P10079 FBP1_STRPU 7.00E-115 GO:0032579; GO:0005509; GO:0016023; GO:0005615 apical lamina of hyaline layer; calcium ion binding; cytoplasmic membrane-bounded vesicle; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) TR43250_c1_g5_i1 Q24498 RY44_DROME 0 GO:0005509; GO:0006874; GO:0016021; GO:0005875; GO:0007275; GO:0006936; GO:0035206; GO:0072347; GO:0005219; GO:0033017 calcium ion binding; cellular calcium ion homeostasis; integral to membrane; microtubule associated complex; multicellular organismal development; muscle contraction; regulation of hemocyte proliferation; response to anesthetic; ryanodine-sensitive calcium-release channel activity; sarcoplasmic reticulum membrane IPR001870; IPR000699; IPR008985; IPR011992; IPR014821; IPR005821; IPR016093; IPR013662; IPR013333; IPR003032; IPR015925; IPR009460; IPR018355; IPR003877; Ryanodine receptor 44F Rya-r44F dry RyR CG10844 Drosophila melanogaster (Fruit fly) TR43250_c1_g6_i1 Q24498 RY44_DROME 0 GO:0005509; GO:0006874; GO:0016021; GO:0005875; GO:0007275; GO:0006936; GO:0035206; GO:0072347; GO:0005219; GO:0033017 calcium ion binding; cellular calcium ion homeostasis; integral to membrane; microtubule associated complex; multicellular organismal development; muscle contraction; regulation of hemocyte proliferation; response to anesthetic; ryanodine-sensitive calcium-release channel activity; sarcoplasmic reticulum membrane IPR001870; IPR000699; IPR008985; IPR011992; IPR014821; IPR005821; IPR016093; IPR013662; IPR013333; IPR003032; IPR015925; IPR009460; IPR018355; IPR003877; Ryanodine receptor 44F Rya-r44F dry RyR CG10844 Drosophila melanogaster (Fruit fly) TR43250_c1_g7_i1 Q5XPI3 RN123_MOUSE 3.00E-17 GO:0005737; GO:0016874; GO:0016567; GO:0008270 cytoplasm; ligase activity; protein ubiquitination; zinc ion binding IPR001870; IPR008985; IPR018355; IPR003877; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF123 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) Rnf123 Kpc1 Mus musculus (Mouse) TR43251_c1_g1_i1 Q9ERG0 LIMA1_MOUSE 3.00E-07 GO:0051015; GO:0051017; GO:0003785; GO:0005737; GO:0005925; GO:0030835; GO:0031529; GO:0001725; GO:0008270 actin filament binding; actin filament bundle assembly; actin monomer binding; cytoplasm; focal adhesion; negative regulation of actin filament depolymerization; ruffle organization; stress fiber; zinc ion binding IPR001781; LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) (mEPLIN) Lima1 D15Ertd366e Eplin Mus musculus (Mouse) TR43251_c1_g3_i1 Q9XTA0 DOPO_HORSE 4.00E-27 GO:0031418; GO:0034466; GO:0042584; GO:0005507; GO:0004500; GO:0016021; GO:0042421; GO:0030658 L-ascorbic acid binding; chromaffin granule lumen; chromaffin granule membrane; copper ion binding; dopamine beta-monooxygenase activity; integral to membrane; norepinephrine biosynthetic process; transport vesicle membrane IPR014784; IPR020611; IPR014783; IPR000323; IPR000945; IPR005018; IPR008977; Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1. Dopamine beta-hydroxylase (EC 1.14.17.1) [Cleaved into: Soluble dopamine beta-hydroxylase] DBH Equus caballus (Horse) TR43253_c1_g1_i1 Q8VD75 HIP1_MOUSE 4.00E-12 GO:0005794; GO:0006919; GO:0097190; GO:0030154; GO:0030276; GO:0048268; GO:0030136; GO:0030665; GO:0006897; GO:0012505; GO:0005634; GO:0035091; GO:0048260; GO:0006355; GO:0006351 "Golgi apparatus; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic signaling pathway; cell differentiation; clathrin binding; clathrin coat assembly; clathrin-coated vesicle; clathrin-coated vesicle membrane; endocytosis; endomembrane system; nucleus; phosphatidylinositol binding; positive regulation of receptor-mediated endocytosis; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR011417; IPR008942; IPR013809; IPR002558; Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I) Hip1 Kiaa4113 Mus musculus (Mouse) TR43253_c1_g2_i1 Q9Y4G6 TLN2_HUMAN 0 GO:0003779; GO:0015629; GO:0007155; GO:0005911; GO:0007043; GO:0005737; GO:0007016; GO:0005916; GO:0005925; GO:0005886; GO:0001726; GO:0005200; GO:0005198; GO:0045202 P00519; P05107 actin binding; actin cytoskeleton; cell adhesion; cell-cell junction; cell-cell junction assembly; cytoplasm; cytoskeletal anchoring at plasma membrane; fascia adherens; focal adhesion; plasma membrane; ruffle; structural constituent of cytoskeleton; structural molecule activity; synapse IPR019749; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR002558; IPR002404; IPR011993; IPR015711; IPR015224; IPR015009; IPR006077; Talin-2 TLN2 KIAA0320 Homo sapiens (Human) TR43253_c1_g3_i1 Q71LX4 TLN2_MOUSE 1.00E-141 GO:0015629; GO:0007155; GO:0005737; GO:0007016; GO:0005916; GO:0005925; GO:0005886; GO:0001726; GO:0005200; GO:0045202 actin cytoskeleton; cell adhesion; cytoplasm; cytoskeletal anchoring at plasma membrane; fascia adherens; focal adhesion; plasma membrane; ruffle; structural constituent of cytoskeleton; synapse IPR019749; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR002558; IPR002404; IPR011993; IPR015711; IPR015224; IPR015009; IPR006077; Talin-2 Tln2 Mus musculus (Mouse) TR43254_c3_g1_i1 Q5F362 CC50A_CHICK 2.00E-53 GO:0016021 integral to membrane IPR005045; Cell cycle control protein 50A (Transmembrane protein 30A) TMEM30A CDC50A RCJMB04_32j24 Gallus gallus (Chicken) TR43254_c3_g1_i2 P53740 YN8S_YEAST 8.00E-24 GO:0016021; GO:0042493 integral to membrane; response to drug IPR005045; Uncharacterized protein YNR048W YNR048W N3453 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR43254_c3_g2_i2 Q6AY41 CC50A_RAT 6.00E-41 GO:0005783; GO:0016021; GO:0070863; GO:0036010 endoplasmic reticulum; integral to membrane; positive regulation of protein exit from endoplasmic reticulum; protein localization to endosome IPR005045; Cell cycle control protein 50A (Transmembrane protein 30A) Tmem30a Cdc50a Rattus norvegicus (Rat) TR43257_c13_g2_i1 O02768 PGH2_RABIT 0 GO:0042640; GO:0050873; GO:0071456; GO:0019371; GO:0005737; GO:0051213; GO:0005789; GO:0020037; GO:0046872; GO:0043005; GO:0005634; GO:0004601; GO:0090336; GO:0031622; GO:0004666; GO:0008217; GO:0042127; GO:0006979 anagen; brown fat cell differentiation; cellular response to hypoxia; cyclooxygenase pathway; cytoplasm; dioxygenase activity; endoplasmic reticulum membrane; heme binding; metal ion binding; neuron projection; nucleus; peroxidase activity; positive regulation of brown fat cell differentiation; positive regulation of fever generation; prostaglandin-endoperoxide synthase activity; regulation of blood pressure; regulation of cell proliferation; response to oxidative stress IPR000742; IPR010255; IPR002007; IPR019791; Lipid metabolism; prostaglandin biosynthesis. Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) PTGS2 COX-2 COX2 Oryctolagus cuniculus (Rabbit) TR43257_c13_g2_i2 O02768 PGH2_RABIT 0 GO:0042640; GO:0050873; GO:0071456; GO:0019371; GO:0005737; GO:0051213; GO:0005789; GO:0020037; GO:0046872; GO:0043005; GO:0005634; GO:0004601; GO:0090336; GO:0031622; GO:0004666; GO:0008217; GO:0042127; GO:0006979 anagen; brown fat cell differentiation; cellular response to hypoxia; cyclooxygenase pathway; cytoplasm; dioxygenase activity; endoplasmic reticulum membrane; heme binding; metal ion binding; neuron projection; nucleus; peroxidase activity; positive regulation of brown fat cell differentiation; positive regulation of fever generation; prostaglandin-endoperoxide synthase activity; regulation of blood pressure; regulation of cell proliferation; response to oxidative stress IPR000742; IPR010255; IPR002007; IPR019791; Lipid metabolism; prostaglandin biosynthesis. Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) PTGS2 COX-2 COX2 Oryctolagus cuniculus (Rabbit) TR43258_c2_g1_i1 O72736 KBTB1_CWPXG 2.00E-39 GO:0030430; GO:0039649 host cell cytoplasm; modulation by virus of host ubiquitin-protein ligase activity IPR011705; IPR000210; IPR011333; IPR013069; IPR015915; IPR006652; IPR024182; Kelch repeat and BTB domain-containing protein 1 KBTB1 A57R Cowpox virus (strain GRI-90 / Grishak) (CPV) TR43258_c2_g1_i2 Q09563 YR47_CAEEL 4.00E-12 IPR011705; IPR000210; IPR011333; IPR013069; IPR015915; IPR006652; Kelch repeat and BTB domain-containing protein F47D12.7 F47D12.7 Caenorhabditis elegans TR43258_c2_g1_i3 P32228 VC04_SWPVK 2.00E-24 IPR011705; IPR000210; IPR011333; IPR013069; IPR011043; IPR015916; IPR006652; IPR024182; Protein C4 C4L Swinepox virus (strain Kasza) (SWPV) TR43258_c2_g1_i4 E0CZ16 KLHL3_MOUSE 2.00E-116 GO:0031463; GO:0003824; GO:0005856; GO:0005829; GO:0072156; GO:0050801; GO:0070936; GO:0042787; GO:0070294 Cul3-RING ubiquitin ligase complex; catalytic activity; cytoskeleton; cytosol; distal tubule morphogenesis; ion homeostasis; protein K48-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; renal sodium ion absorption IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; IPR011041; Protein modification; protein ubiquitination. Kelch-like protein 3 Klhl3 Mus musculus (Mouse) TR43259_c17_g2_i2 P41413 PCSK5_RAT 9.00E-34 GO:0005794; GO:0009952; GO:0042089; GO:0007566; GO:0048566; GO:0048706; GO:0012505; GO:0005615; GO:0007507; GO:0016021; GO:0001822; GO:0035108; GO:0042277; GO:0043043; GO:0016486; GO:0006508; GO:0002001; GO:0030323; GO:0030141; GO:0004252; GO:0006465 Golgi apparatus; anterior/posterior pattern specification; cytokine biosynthetic process; embryo implantation; embryonic digestive tract development; embryonic skeletal system development; endomembrane system; extracellular space; heart development; integral to membrane; kidney development; limb morphogenesis; peptide binding; peptide biosynthetic process; peptide hormone processing; proteolysis; renin secretion into blood stream; respiratory tube development; secretory granule; serine-type endopeptidase activity; signal peptide processing IPR000742; IPR006212; IPR008979; IPR009030; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (Subtilisin/kexin-like protease PC5) (rPC5) Pcsk5 Rattus norvegicus (Rat) TR43259_c17_g3_i3 Q96RW7 HMCN1_HUMAN 3.00E-66 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR43259_c17_g6_i2 P13134 KEX2_YEAST 3.00E-13 GO:0005794; GO:0016021; GO:0046872; GO:0007323; GO:0006508; GO:0004252; GO:0005802 P32790 Golgi apparatus; integral to membrane; metal ion binding; peptide pheromone maturation; proteolysis; serine-type endopeptidase activity; trans-Golgi network IPR008979; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR002884; Kexin (EC 3.4.21.61) (Protease KEX2) (Proteinase YSCF) KEX2 QDS1 YNL238W N1122 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR43260_c1_g3_i1 Q24306 IAP1_DROME 2.00E-26 GO:0019788; GO:0016055; GO:0048800; GO:0007298; GO:0008407; GO:0004869; GO:0005737; GO:0008354; GO:0097340; GO:1990001; GO:0043066; GO:0046673; GO:0005634; GO:0090263; GO:0031398; GO:0042787; GO:0045035; GO:0007289; GO:0004842; GO:0008270 P25843; Q86PE7; Q9XYF4; Q24475; Q24106 NEDD8 ligase activity; Wnt receptor signaling pathway; antennal morphogenesis; border follicle cell migration; chaeta morphogenesis; cysteine-type endopeptidase inhibitor activity; cytoplasm; germ cell migration; inhibition of cysteine-type endopeptidase activity; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of compound eye retinal cell programmed cell death; nucleus; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; sensory organ precursor cell division; spermatid nucleus differentiation; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001841; IPR013083; Apoptosis 1 inhibitor (EC 6.3.2.-) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (dIAP1) (Protein thread) th Iap1 CG12284 Drosophila melanogaster (Fruit fly) TR43260_c3_g1_i1 Q13489 BIRC3_HUMAN 6.00E-20 GO:0038061; GO:0035666; GO:0006915; GO:0007166; GO:0005829; GO:0045087; GO:0070266; GO:0043066; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0043123; GO:0039535; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0034138; GO:0034142; GO:0004842; GO:0008270 Q13546; O43353; Q9Y572; P57078; Q12933 NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; apoptotic process; cell surface receptor signaling pathway; cytosol; innate immune response; necroptosis; negative regulation of apoptotic process; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of RIG-I signaling pathway; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Apoptosis inhibitor 2) (API2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (IAP-1) (hIAP-1) (hIAP1) (RING finger protein 49) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 IAP1 MIHC RNF49 Homo sapiens (Human) TR43260_c3_g1_i2 Q8R516 MIB2_MOUSE 2.00E-06 GO:0007219; GO:0005769; GO:0043123; GO:0004871; GO:0000151; GO:0004842; GO:0008270 Notch signaling pathway; early endosome; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity; ubiquitin ligase complex; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Dystrophin-like protein) (Dyslike) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) Mib2 Skd Mus musculus (Mouse) TR43260_c3_g1_i4 Q24307 IAP2_DROME 8.00E-18 GO:0050829; GO:0043066; GO:0043154; GO:0061057; GO:0006964; GO:0033160; GO:0070534; GO:0007423; GO:0008270 "defense response to Gram-negative bacterium; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; peptidoglycan recognition protein signaling pathway; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; positive regulation of protein import into nucleus, translocation; protein K63-linked ubiquitination; sensory organ development; zinc ion binding" IPR001370; IPR001841; IPR013083; Apoptosis 2 inhibitor (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) (dIAP2) Iap2 DIHA ILP CG8293 Drosophila melanogaster (Fruit fly) TR43261_c1_g1_i1 Q9VZI3 UN112_DROME 0 GO:0048738; GO:0050839; GO:0007160; GO:0005737; GO:0050829; GO:0005543 cardiac muscle tissue development; cell adhesion molecule binding; cell-matrix adhesion; cytoplasm; defense response to Gram-negative bacterium; phospholipid binding IPR019749; IPR014352; IPR019748; IPR011993; IPR001849; Unc-112-related protein (Fermitin-1) Fit1 CG14991 Drosophila melanogaster (Fruit fly) TR43261_c1_g1_i4 Q9VZI3 UN112_DROME 0 GO:0048738; GO:0050839; GO:0007160; GO:0005737; GO:0050829; GO:0005543 cardiac muscle tissue development; cell adhesion molecule binding; cell-matrix adhesion; cytoplasm; defense response to Gram-negative bacterium; phospholipid binding IPR019749; IPR014352; IPR019748; IPR011993; IPR001849; Unc-112-related protein (Fermitin-1) Fit1 CG14991 Drosophila melanogaster (Fruit fly) TR43261_c1_g1_i8 Q8K1B8 URP2_MOUSE 2.00E-127 GO:0030054; GO:0042995; GO:0033622; GO:0005178; GO:0007159; GO:0005543; GO:0070527; GO:0002102; GO:0033632 cell junction; cell projection; integrin activation; integrin binding; leukocyte cell-cell adhesion; phospholipid binding; platelet aggregation; podosome; regulation of cell-cell adhesion mediated by integrin IPR019749; IPR014352; IPR019748; IPR011993; IPR001849; Fermitin family homolog 3 (Kindlin-3) (Unc-112-related protein 2) Fermt3 Kind3 Urp2 Mus musculus (Mouse) TR43261_c1_g1_i9 Q9VZI3 UN112_DROME 0 GO:0048738; GO:0050839; GO:0007160; GO:0005737; GO:0050829; GO:0005543 cardiac muscle tissue development; cell adhesion molecule binding; cell-matrix adhesion; cytoplasm; defense response to Gram-negative bacterium; phospholipid binding IPR019749; IPR014352; IPR019748; IPR011993; IPR001849; Unc-112-related protein (Fermitin-1) Fit1 CG14991 Drosophila melanogaster (Fruit fly) TR43262_c3_g1_i1 Q8IUD2 RB6I2_HUMAN 9.00E-92 GO:0000139; GO:0007252; GO:0008385; GO:0043522; GO:0007275; GO:0051092; GO:0042734; GO:0015031; GO:0042147 Q8R0S4 "Golgi membrane; I-kappaB phosphorylation; IkappaB kinase complex; leucine zipper domain binding; multicellular organismal development; positive regulation of NF-kappaB transcription factor activity; presynaptic membrane; protein transport; retrograde transport, endosome to Golgi" IPR019323; IPR019018; ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) ERC1 ELKS KIAA1081 RAB6IP2 Homo sapiens (Human) TR43262_c3_g2_i2 Q8K3M6 ERC2_RAT 1.00E-19 GO:0030165; GO:0030054; GO:0005783; GO:0030426; GO:0043025; GO:0014069; GO:0042734; GO:0043234; GO:0032403; GO:0007416; GO:0043195 PDZ domain binding; cell junction; endoplasmic reticulum; growth cone; neuronal cell body; postsynaptic density; presynaptic membrane; protein complex; protein complex binding; synapse assembly; terminal bouton IPR019323; ERC protein 2 (CAZ-associated structural protein 1) (CAST1) (Cast) (Cytomatrix protein p110) Erc2 Cast1 Cmbp Rattus norvegicus (Rat) TR43262_c4_g1_i1 Q24372 LACH_DROME 4.00E-38 GO:0031225; GO:0061343; GO:0007156; GO:0035160; GO:0016331; GO:0005886; GO:0042803; GO:0035151; GO:0005918; GO:0019991 Q9VGH2 "anchored to membrane; cell adhesion involved in heart morphogenesis; homophilic cell adhesion; maintenance of epithelial integrity, open tracheal system; morphogenesis of embryonic epithelium; plasma membrane; protein homodimerization activity; regulation of tube size, open tracheal system; septate junction; septate junction assembly" IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Lachesin Lac CG12369 Drosophila melanogaster (Fruit fly) TR43263_c6_g1_i2 O01761 UNC89_CAEEL 9.00E-58 GO:0005524; GO:0031430; GO:0005089; GO:0005543; GO:0004672; GO:0035023; GO:0030241 ATP binding; M band; Rho guanyl-nucleotide exchange factor activity; phospholipid binding; protein kinase activity; regulation of Rho protein signal transduction; skeletal muscle myosin thick filament assembly IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR007850; IPR001452; Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans TR43263_c7_g2_i1 Q8WZ42 TITIN_HUMAN 4.00E-47 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR43266_c0_g1_i1 Q4ZJM9 C1QL4_MOUSE 2.00E-11 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) TR43267_c0_g1_i1 Q9VE46 SC5A7_DROME 6.00E-40 GO:0008292; GO:0015171; GO:0015220; GO:0016021; GO:0006814; GO:0015293 acetylcholine biosynthetic process; amino acid transmembrane transporter activity; choline transmembrane transporter activity; integral to membrane; sodium ion transport; symporter activity IPR001734; High-affinity choline transporter 1 CG7708 Drosophila melanogaster (Fruit fly) TR43273_c0_g1_i1 Q00PJ9 CAV1_ATEAB 6.00E-26 GO:0000139; GO:0031295; GO:0005901; GO:0005768 Golgi membrane; T cell costimulation; caveola; endosome IPR001612; IPR015504; IPR018361; Caveolin-1 CAV1 Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog) TR43287_c0_g1_i1 Q8ZWC4 Y1861_PYRAE 2.00E-07 IPR002110; IPR020683; Putative ankyrin repeat protein PAE1861 PAE1861 Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827) TR43291_c0_g1_i1 P35021 EF1A_SULSO 2.00E-23 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; translation elongation factor activity IPR000795; IPR027417; IPR005225; IPR009000; IPR009001; IPR004539; IPR004161; IPR004160; Elongation factor 1-alpha (EF-1-alpha) (Elongation factor Tu) (EF-Tu) tuf tef1 SSO0216 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) TR43302_c10_g1_i2 O35141 RASF5_RAT 4.00E-49 GO:0006915; GO:0005737; GO:0035556; GO:0046872; GO:0005874; GO:0005634; GO:0031398 apoptotic process; cytoplasm; intracellular signal transduction; metal ion binding; microtubule; nucleus; positive regulation of protein ubiquitination IPR002219; IPR000159; IPR011524; Ras association domain-containing protein 5 (Maxp1) (New ras effector 1) Rassf5 Nore1 Rattus norvegicus (Rat) TR43302_c10_g1_i3 Q9NS23 RASF1_HUMAN 7.00E-35 GO:0007265; GO:0007050; GO:0005737; GO:0005874; GO:0015630; GO:0005815; GO:0071157; GO:0005634; GO:0005886; GO:0031398; GO:0050821; GO:0006974; GO:0000922; GO:0008270 Q12834; Q9UER7; Q66K89; Q01844; O95166; P60520; P01112; O60341; Q9GZQ8; Q9BXW4; Q00987; Q13188; Q13043; O43463 Ras protein signal transduction; cell cycle arrest; cytoplasm; microtubule; microtubule cytoskeleton; microtubule organizing center; negative regulation of cell cycle arrest; nucleus; plasma membrane; positive regulation of protein ubiquitination; protein stabilization; response to DNA damage stimulus; spindle pole; zinc ion binding IPR002219; IPR000159; IPR011524; Ras association domain-containing protein 1 RASSF1 RDA32 Homo sapiens (Human) TR43302_c10_g1_i4 O35141 RASF5_RAT 4.00E-49 GO:0006915; GO:0005737; GO:0035556; GO:0046872; GO:0005874; GO:0005634; GO:0031398 apoptotic process; cytoplasm; intracellular signal transduction; metal ion binding; microtubule; nucleus; positive regulation of protein ubiquitination IPR002219; IPR000159; IPR011524; Ras association domain-containing protein 5 (Maxp1) (New ras effector 1) Rassf5 Nore1 Rattus norvegicus (Rat) TR43302_c9_g2_i1 Q6GNY1 MIB1_XENLA 0 GO:0007219; GO:0005737; GO:0004842; GO:0008270 Notch signaling pathway; cytoplasm; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase mib1 (EC 6.3.2.-) (Mind bomb homolog 1) mib1 Xenopus laevis (African clawed frog) TR43302_c9_g2_i2 Q505D1 ANR28_MOUSE 9.00E-24 GO:0005654 nucleoplasm IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) Ankrd28 Mus musculus (Mouse) TR43302_c9_g2_i3 Q6GNY1 MIB1_XENLA 0 GO:0007219; GO:0005737; GO:0004842; GO:0008270 Notch signaling pathway; cytoplasm; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase mib1 (EC 6.3.2.-) (Mind bomb homolog 1) mib1 Xenopus laevis (African clawed frog) TR43302_c9_g2_i4 O15084 ANR28_HUMAN 4.00E-24 GO:0005654 Q14185; O00743; Q9UPN7; O75170; Q5H9R7; Q9H2K2 nucleoplasm IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) ANKRD28 KIAA0379 Homo sapiens (Human) TR43302_c9_g2_i5 Q80YE7 DAPK1_MOUSE 8.00E-23 GO:0005524; GO:0015629; GO:0005516; GO:0004683; GO:0071346; GO:0005829; GO:0008625; GO:0007243; GO:0043066; GO:1902042; GO:0017148; GO:0046777; GO:0004672; GO:2000310 Q01097 ATP binding; actin cytoskeleton; calmodulin binding; calmodulin-dependent protein kinase activity; cellular response to interferon-gamma; cytosol; extrinsic apoptotic signaling pathway via death domain receptors; intracellular protein kinase cascade; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of translation; protein autophosphorylation; protein kinase activity; regulation of N-methyl-D-aspartate selective glutamate receptor activity IPR002110; IPR020683; IPR011029; IPR000488; IPR011009; IPR020675; IPR027417; IPR000719; IPR017441; IPR002290; IPR008271; Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) Dapk1 Mus musculus (Mouse) TR43302_c9_g2_i6 Q12955 ANK3_HUMAN 1.00E-30 GO:0043001; GO:0030315; GO:0007411; GO:0043194; GO:0007409; GO:0016323; GO:0045296; GO:0009986; GO:0043034; GO:0014704; GO:0044325; GO:0016328; GO:0005764; GO:0072660; GO:0071709; GO:0000281; GO:0033268; GO:0033270; GO:0010628; GO:1900827; GO:0045838; GO:2000651; GO:0010765; GO:0045211; GO:0030674; GO:0072661; GO:0019228; GO:0043266; GO:0007165; GO:0030507; GO:0014731; GO:0005200; GO:0050808 "Golgi to plasma membrane protein transport; T-tubule; axon guidance; axon initial segment; axonogenesis; basolateral plasma membrane; cadherin binding; cell surface; costamere; intercalated disc; ion channel binding; lateral plasma membrane; lysosome; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; node of Ranvier; paranode region of axon; positive regulation of gene expression; positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; postsynaptic membrane; protein binding, bridging; protein targeting to plasma membrane; regulation of action potential in neuron; regulation of potassium ion transport; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton; synapse organization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) TR43302_c9_g2_i7 Q6GNY1 MIB1_XENLA 0 GO:0007219; GO:0005737; GO:0004842; GO:0008270 Notch signaling pathway; cytoplasm; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase mib1 (EC 6.3.2.-) (Mind bomb homolog 1) mib1 Xenopus laevis (African clawed frog) TR43302_c9_g3_i1 O95714 HERC2_HUMAN 4.00E-11 GO:0006281; GO:0032183; GO:0005814; GO:0005737; GO:0005085; GO:0020037; GO:0006886; GO:0005634; GO:0042787; GO:0004842; GO:0008270 DNA repair; SUMO binding; centriole; cytoplasm; guanyl-nucleotide exchange factor activity; heme binding; intracellular protein transport; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR004939; IPR006624; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) HERC2 Homo sapiens (Human) TR43305_c0_g1_i1 Q5RAH0 LAP4A_PONAB 5.00E-07 GO:0005794; GO:0012505; GO:0016021; GO:0006810 Golgi apparatus; endomembrane system; integral to membrane; transport IPR004687; IPR018396; Lysosomal-associated transmembrane protein 4A LAPTM4A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR43308_c0_g1_i1 O22584 RS14_LUPLU 3.00E-33 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001971; IPR018102; 40S ribosomal protein S14 RPS14 Lupinus luteus (European yellow lupin) TR43309_c10_g1_i1 Q92947 GCDH_HUMAN 0 GO:0034641; GO:0019395; GO:0000062; GO:0046949; GO:0050660; GO:0004361; GO:0006554; GO:0005743; GO:0005759; GO:0006568 P62993; P29474; P49768 cellular nitrogen compound metabolic process; fatty acid oxidation; fatty-acyl-CoA binding; fatty-acyl-CoA biosynthetic process; flavin adenine dinucleotide binding; glutaryl-CoA dehydrogenase activity; lysine catabolic process; mitochondrial inner membrane; mitochondrial matrix; tryptophan metabolic process IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Amino-acid metabolism; lysine degradation. Amino-acid metabolism; tryptophan metabolism. "Glutaryl-CoA dehydrogenase, mitochondrial (GCD) (EC 1.3.8.6)" GCDH Homo sapiens (Human) TR43309_c10_g1_i2 O32176 FADE_BACSU 4.00E-40 GO:0003995; GO:0006635; GO:0050660 acyl-CoA dehydrogenase activity; fatty acid beta-oxidation; flavin adenine dinucleotide binding IPR006089; IPR006091; IPR009075; IPR013786; IPR009100; Lipid metabolism; fatty acid beta-oxidation. Probable acyl-CoA dehydrogenase (EC 1.3.99.-) fadE yusJ BSU32820 Bacillus subtilis (strain 168) TR43309_c12_g1_i3 O88879 APAF_MOUSE 2.00E-09 GO:0043531; GO:0005524; GO:0005794; GO:0008635; GO:0006309; GO:0008656; GO:0005829; GO:0006952; GO:0030900; GO:0001843; GO:0051402; GO:0005634; GO:2001235 ADP binding; ATP binding; Golgi apparatus; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; apoptotic DNA fragmentation; cysteine-type endopeptidase activator activity involved in apoptotic process; cytosol; defense response; forebrain development; neural tube closure; neuron apoptotic process; nucleus; positive regulation of apoptotic signaling pathway IPR017251; IPR001315; IPR011029; IPR000767; IPR020472; IPR002182; IPR027417; IPR015943; IPR001680; IPR019775; IPR017986; Apoptotic protease-activating factor 1 (APAF-1) Apaf1 Mus musculus (Mouse) TR43309_c12_g4_i1 Q54WS5 ROCO6_DICDI 2.00E-06 GO:0005524; GO:0005525; GO:0016021; GO:0005543; GO:0004674; GO:0007264 ATP binding; GTP binding; integral to membrane; phospholipid binding; protein serine/threonine kinase activity; small GTPase mediated signal transduction IPR011009; IPR001611; IPR025875; IPR003591; IPR027417; IPR011993; IPR001849; IPR000719; IPR017441; IPR011047; IPR020859; IPR001245; IPR008271; IPR001806; IPR015943; IPR001680; Probable serine/threonine-protein kinase roco6 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 6) roco6 DDB_G0279417 Dictyostelium discoideum (Slime mold) TR43309_c2_g4_i1 Q6DRG7 MYPT1_DANRE 4.00E-06 GO:0071889; GO:0072357; GO:0051017; GO:0005737; GO:0001889; GO:0019208; GO:0030155; GO:0035507 14-3-3 protein binding; PTW/PP1 phosphatase complex; actin filament bundle assembly; cytoplasm; liver development; phosphatase regulator activity; regulation of cell adhesion; regulation of myosin-light-chain-phosphatase activity IPR002110; IPR020683; IPR017401; Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) ppp1r12a mbs mypt1 si:dkey-28j4.1 zgc:110448 Danio rerio (Zebrafish) (Brachydanio rerio) TR43309_c9_g1_i1 Q5UQ58 YR664_MIMIV 1.00E-06 IPR002110; IPR020683; Putative ankyrin repeat protein R664 MIMI_R664 Acanthamoeba polyphaga mimivirus (APMV) TR43309_c9_g3_i1 Q8IWZ3 ANKH1_HUMAN 5.00E-10 GO:0003723; GO:0005737; GO:0005634 Q9NRI5 RNA binding; cytoplasm; nucleus IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) TR43309_c9_g3_i2 Q8Q0U0 Y045_METMA 1.00E-11 IPR002110; IPR020683; Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) TR43310_c3_g2_i1 Q69ZS8 KAZRN_MOUSE 3.00E-119 GO:0001533; GO:0005737; GO:0030057; GO:0031424; GO:0005634 cornified envelope; cytoplasm; desmosome; keratinization; nucleus IPR001660; IPR013761; IPR011510; IPR021129; Kazrin Kazn Kaz Kiaa1026 Mus musculus (Mouse) TR43310_c3_g2_i2 Q69ZS8 KAZRN_MOUSE 6.00E-119 GO:0001533; GO:0005737; GO:0030057; GO:0031424; GO:0005634 cornified envelope; cytoplasm; desmosome; keratinization; nucleus IPR001660; IPR013761; IPR011510; IPR021129; Kazrin Kazn Kaz Kiaa1026 Mus musculus (Mouse) TR43312_c1_g1_i1 O95425 SVIL_HUMAN 0 GO:0015629; GO:0051015; GO:0030054; GO:0043034; GO:0007010; GO:0071437; GO:0005634; GO:0005886; GO:0002102; GO:0007519 P20929 actin cytoskeleton; actin filament binding; cell junction; costamere; cytoskeleton organization; invadopodium; nucleus; plasma membrane; podosome; skeletal muscle tissue development IPR007123; IPR015628; IPR007122; IPR003128; Supervillin (Archvillin) (p205/p250) SVIL Homo sapiens (Human) TR43312_c1_g1_i2 O95425 SVIL_HUMAN 0 GO:0015629; GO:0051015; GO:0030054; GO:0043034; GO:0007010; GO:0071437; GO:0005634; GO:0005886; GO:0002102; GO:0007519 P20929 actin cytoskeleton; actin filament binding; cell junction; costamere; cytoskeleton organization; invadopodium; nucleus; plasma membrane; podosome; skeletal muscle tissue development IPR007123; IPR015628; IPR007122; IPR003128; Supervillin (Archvillin) (p205/p250) SVIL Homo sapiens (Human) TR43326_c0_g1_i1 Q9DAM9 FANK1_MOUSE 4.00E-11 GO:0005737; GO:0005634 cytoplasm; nucleus IPR002110; IPR020683; IPR003961; IPR013783; Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell-specific gene 1 protein) (GSG1) Fank1 Mus musculus (Mouse) TR43335_c0_g1_i1 Q02241 KIF23_HUMAN 7.00E-45 GO:0005524; GO:0019886; GO:0007596; GO:0097149; GO:0005813; GO:0000910; GO:0005829; GO:0045171; GO:0005871; GO:0005874; GO:0008017; GO:0003777; GO:0007018; GO:0030496; GO:0000022; GO:0005654; GO:0032467; GO:0051256 P62330; P62331; Q9NR09; Q9H0H5; P63104 ATP binding; antigen processing and presentation of exogenous peptide antigen via MHC class II; blood coagulation; centralspindlin complex; centrosome; cytokinesis; cytosol; intercellular bridge; kinesin complex; microtubule; microtubule binding; microtubule motor activity; microtubule-based movement; midbody; mitotic spindle elongation; nucleoplasm; positive regulation of cytokinesis; spindle midzone assembly involved in mitosis IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) KIF23 KNSL5 MKLP1 Homo sapiens (Human) TR43351_c0_g1_i1 P46939 UTRO_HUMAN 4.00E-14 GO:0003779; GO:0005509; GO:0030054; GO:0005737; GO:0005856; GO:0016010; GO:0030175; GO:0006936; GO:0007517; GO:0031594; GO:0005634; GO:0005886; GO:0001954; GO:0045211; GO:0043234; GO:2000649; GO:0008270 actin binding; calcium ion binding; cell junction; cytoplasm; cytoskeleton; dystrophin-associated glycoprotein complex; filopodium; muscle contraction; muscle organ development; neuromuscular junction; nucleus; plasma membrane; positive regulation of cell-matrix adhesion; postsynaptic membrane; protein complex; regulation of sodium ion transmembrane transporter activity; zinc ion binding IPR001589; IPR001715; IPR016344; IPR011992; IPR015153; IPR015154; IPR018159; IPR002017; IPR001202; IPR000433; Utrophin (Dystrophin-related protein 1) (DRP-1) UTRN DMDL DRP1 Homo sapiens (Human) TR4336_c0_g1_i1 Q9BY07 S4A5_HUMAN 3.00E-13 GO:0016324; GO:0005452; GO:0016021; GO:0005886; GO:0008510 apical plasma membrane; inorganic anion exchanger activity; integral to membrane; plasma membrane; sodium:bicarbonate symporter activity IPR013769; IPR011531; IPR003020; IPR003024; IPR016152; Electrogenic sodium bicarbonate cotransporter 4 (NBCe2) (Solute carrier family 4 member 5) SLC4A5 NBC4 Homo sapiens (Human) TR4337_c0_g1_i1 P02566 MYO4_CAEEL 4.00E-23 GO:0005524; GO:0051015; GO:0048017; GO:0040011; GO:0000146; GO:0006936; GO:0018991; GO:0043050; GO:0030241; GO:0005863; GO:0008307 G5EG62 ATP binding; actin filament binding; inositol lipid-mediated signaling; locomotion; microfilament motor activity; muscle contraction; oviposition; pharyngeal pumping; skeletal muscle myosin thick filament assembly; striated muscle myosin thick filament; structural constituent of muscle IPR027401; IPR001609; IPR004009; IPR008989; IPR002928; IPR027417; Myosin-4 (Myosin heavy chain B) (MHC B) (Uncoordinated protein 54) unc-54 myo-4 F11C3.3 Caenorhabditis elegans TR43376_c0_g1_i1 O57579 AMPN_CHICK 1.00E-20 GO:0004177; GO:0016021; GO:0008237; GO:0005886; GO:0006508; GO:0008270 aminopeptidase activity; integral to membrane; metallopeptidase activity; plasma membrane; proteolysis; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (EC 3.4.11.2) (Aminopeptidase Ey) (EC 3.4.11.20) ANPEP APDE Gallus gallus (Chicken) TR43423_c0_g1_i1 Q8K0U4 HS12A_MOUSE 2.00E-11 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR43426_c0_g1_i1 P40821 CRJ1C_TRICY 2.00E-06 GO:0005212 structural constituent of eye lens IPR005502; Crystallin J1C Tripedalia cystophora (Jellyfish) TR43431_c0_g1_i1 P46058 EDSP_CYNPY 1.00E-09 IPR023307; IPR001064; IPR004991; IPR011024; Epidermal differentiation-specific protein Cynops pyrrhogaster (Japanese common newt) TR43478_c0_g1_i1 Q6V0K7 OIT3_RAT 2.00E-11 GO:0005635 nuclear envelope IPR000742; IPR001507; Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein) Oit3 Lzp Rattus norvegicus (Rat) TR43488_c0_g1_i1 Q9VT28 FRY_DROME 6.00E-62 GO:0048800; GO:0045177; GO:0005938; GO:0008407; GO:0070593; GO:0035317; GO:0048601; GO:0045860; GO:0045893; GO:0048814; GO:0042052; GO:0006351 "antennal morphogenesis; apical part of cell; cell cortex; chaeta morphogenesis; dendrite self-avoidance; imaginal disc-derived wing hair organization; oocyte morphogenesis; positive regulation of protein kinase activity; positive regulation of transcription, DNA-dependent; regulation of dendrite morphogenesis; rhabdomere development; transcription, DNA-dependent" IPR016024; IPR025614; IPR025481; Protein furry fry CG32045 Drosophila melanogaster (Fruit fly) TR43499_c0_g1_i1 Q9JJR6 CK016_MOUSE 2.00E-06 Uncharacterized protein C11orf16 homolog D7h11orf16 Mus musculus (Mouse) TR43503_c0_g1_i1 Q29486 PPBT_FELCA 6.00E-12 GO:0004035; GO:0031225; GO:0016311; GO:0046872; GO:0005886; GO:0033280 alkaline phosphatase activity; anchored to membrane; dephosphorylation; metal ion binding; plasma membrane; response to vitamin D IPR017849; IPR001952; IPR018299; IPR017850; "Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)" ALPL Felis catus (Cat) (Felis silvestris catus) TR43537_c0_g1_i1 B4JII0 SPAST_DROGR 5.00E-23 GO:0005524; GO:0008344; GO:0030154; GO:0051301; GO:0005813; GO:0005694; GO:0005737; GO:0016021; GO:0005874; GO:0008017; GO:0051013; GO:0008568; GO:0007079; GO:0000022; GO:0007399; GO:0005634; GO:0031117; GO:0034214; GO:0050803; GO:0005819 ATP binding; adult locomotory behavior; cell differentiation; cell division; centrosome; chromosome; cytoplasm; integral to membrane; microtubule; microtubule binding; microtubule severing; microtubule-severing ATPase activity; mitotic chromosome movement towards spindle pole; mitotic spindle elongation; nervous system development; nucleus; positive regulation of microtubule depolymerization; protein hexamerization; regulation of synapse structure and activity; spindle IPR003593; IPR003959; IPR003960; IPR007330; IPR027417; IPR017179; Spastin (EC 3.6.4.3) spas GH18484 Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) TR43540_c0_g1_i1 Q29RU2 OIT3_BOVIN 9.00E-10 GO:0005509; GO:0005635 calcium ion binding; nuclear envelope IPR000742; IPR000152; IPR018097; IPR009030; IPR001507; Oncoprotein-induced transcript 3 protein OIT3 Bos taurus (Bovine) TR43541_c0_g1_i1 P11940 PABP1_HUMAN 1.00E-10 GO:0071013; GO:0010494; GO:0005829; GO:0031047; GO:0006378; GO:0000398; GO:0048255; GO:2000623; GO:0000184; GO:0000289; GO:0000166; GO:0008143; GO:1900153; GO:0060213; GO:0008494; GO:0006413 Q99700; O00571; Q04637; Q8IYD1; Q14103-4; P35568; Q9H074; Q96Q15; Q9UPQ9; Q9HCJ0; Q14106 "catalytic step 2 spliceosome; cytoplasmic stress granule; cytosol; gene silencing by RNA; mRNA polyadenylation; mRNA splicing, via spliceosome; mRNA stabilization; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nuclear-transcribed mRNA poly(A) tail shortening; nucleotide binding; poly(A) RNA binding; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; translation activator activity; translational initiation" IPR012677; IPR006515; IPR002004; IPR000504; Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) PABPC1 PAB1 PABP1 PABPC2 Homo sapiens (Human) TR4356_c0_g1_i1 Q86MA7 PRQFV_APLCA 1.00E-14 GO:0005576; GO:0007218 extracellular region; neuropeptide signaling pathway Protein PRQFV-amide [Cleaved into: AREFV-amide; PRQFV-amide (PRQFVa); VRDFV-amide; VREFV-amide; IREFV-amide] Aplysia californica (California sea hare) TR43567_c0_g1_i1 Q14315 FLNC_HUMAN 7.00E-13 GO:0030018; GO:0034329; GO:0043034; GO:0005856; GO:0005829; GO:0048747; GO:0042383; GO:0016528 P00519; P46108; O75923; P62993; Q9UBF9 Z disc; cell junction assembly; costamere; cytoskeleton; cytosol; muscle fiber development; sarcolemma; sarcoplasm IPR001589; IPR001715; IPR003961; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) FLNC ABPL FLN2 Homo sapiens (Human) TR43570_c0_g1_i1 Q96RW7 HMCN1_HUMAN 3.00E-22 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR43576_c0_g1_i1 P20693 FCER2_MOUSE 1.00E-06 GO:0030246; GO:0009897; GO:0016021; GO:0046872; GO:0002925; GO:0051712; GO:0051000; GO:0051770 carbohydrate binding; external side of plasma membrane; integral to membrane; metal ion binding; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of killing of cells of other organism; positive regulation of nitric-oxide synthase activity; positive regulation of nitric-oxide synthase biosynthetic process IPR001304; IPR016186; IPR018378; IPR016187; Low affinity immunoglobulin epsilon Fc receptor (Fc-epsilon-RII) (Lymphocyte IgE receptor) (CD antigen CD23) Fcer2 Fcer2a Mus musculus (Mouse) TR43586_c0_g1_i1 Q94407 NHR48_CAEEL 5.00E-15 GO:0005634; GO:0043565; GO:0003700; GO:0043401; GO:0003707; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone mediated signaling pathway; steroid hormone receptor activity; transcription, DNA-dependent; zinc ion binding" IPR008946; IPR001628; IPR013088; Nuclear hormone receptor family member nhr-48 nhr-48 ZK662.3 Caenorhabditis elegans TR43615_c0_g1_i1 Q68F60 CUE2B_XENLA 2.00E-11 GO:0005737; GO:0005634 cytoplasm; nucleus CUE domain-containing protein 2-B cuedc2-b Xenopus laevis (African clawed frog) TR4362_c0_g1_i1 Q99549 MPP8_HUMAN 1.00E-08 GO:0007049; GO:0005737; GO:0035064; GO:0045892; GO:0005720; GO:0000788; GO:0005730; GO:0005886; GO:0044030; GO:0006351 Q9H9B1; P68431; Q15047 "cell cycle; cytoplasm; methylated histone residue binding; negative regulation of transcription, DNA-dependent; nuclear heterochromatin; nuclear nucleosome; nucleolus; plasma membrane; regulation of DNA methylation; transcription, DNA-dependent" IPR002110; IPR020683; IPR023780; IPR000953; IPR016197; IPR023779; M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) MPHOSPH8 MPP8 Homo sapiens (Human) TR43625_c0_g1_i1 A0E358 CATL2_PARTE 8.00E-12 GO:0008234; GO:0005576; GO:0006508 cysteine-type peptidase activity; extracellular region; proteolysis IPR000169; IPR013128; IPR000668; IPR013201; Cathepsin L 2 (EC 3.4.22.15) GSPATT00022898001 Paramecium tetraurelia TR4365_c0_g1_i1 Q400C7 AMZ2_RAT 9.00E-20 GO:0008237; GO:0006508; GO:0008270 metallopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR012962; Archaemetzincin-2 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 2) Amz2 Rattus norvegicus (Rat) TR43658_c0_g1_i1 Q0IIF9 CP2U1_BOVIN 2.00E-45 GO:0070330; GO:0005789; GO:0020037; GO:0016021; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; integral to membrane; iron ion binding IPR001128; IPR017972; IPR002401; IPR008069; Cytochrome P450 2U1 (EC 1.14.14.1) CYP2U1 Bos taurus (Bovine) TR43658_c0_g2_i1 P10635 CP2D6_HUMAN 2.00E-46 GO:0009822; GO:0070330; GO:0009804; GO:0008144; GO:0042737; GO:0005789; GO:0020037; GO:0005506; GO:0033076; GO:0005739; GO:0004497; GO:0016098; GO:0051100; GO:0090350; GO:0070989; GO:0044281; GO:0008202; GO:0006805 alkaloid catabolic process; aromatase activity; coumarin metabolic process; drug binding; drug catabolic process; endoplasmic reticulum membrane; heme binding; iron ion binding; isoquinoline alkaloid metabolic process; mitochondrion; monooxygenase activity; monoterpenoid metabolic process; negative regulation of binding; negative regulation of cellular organofluorine metabolic process; oxidative demethylation; small molecule metabolic process; steroid metabolic process; xenobiotic metabolic process IPR001128; IPR017972; IPR002401; IPR008069; Cytochrome P450 2D6 (EC 1.14.14.1) (CYPIID6) (Cytochrome P450-DB1) (Debrisoquine 4-hydroxylase) CYP2D6 CYP2DL1 Homo sapiens (Human) TR43674_c0_g1_i1 P40480 HOS4_YEAST 2.00E-07 GO:0034967; GO:0016575; GO:0045835 P38262 Set3 complex; histone deacetylation; negative regulation of meiosis IPR002110; IPR020683; Protein HOS4 HOS4 YIL112W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR43680_c0_g1_i1 Q04666 HES1_RAT 1.00E-18 GO:0071820; GO:0001078; GO:0007262; GO:0021861; GO:2000978; GO:0060253; GO:0048715; GO:2000974; GO:0097150; GO:0005654; GO:0043388; GO:0048711; GO:0042517; GO:0006461; GO:0042803; GO:0043565 N-box binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; STAT protein import into nucleus; forebrain radial glial cell differentiation; negative regulation of forebrain neuron differentiation; negative regulation of glial cell proliferation; negative regulation of oligodendrocyte differentiation; negative regulation of pro-B cell differentiation; neuronal stem cell maintenance; nucleoplasm; positive regulation of DNA binding; positive regulation of astrocyte differentiation; positive regulation of tyrosine phosphorylation of Stat3 protein; protein complex assembly; protein homodimerization activity; sequence-specific DNA binding IPR011598; IPR003650; IPR018352; Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy-like protein) (RHL) Hes1 Hes-1 Hl Rattus norvegicus (Rat) TR4371_c0_g1_i1 Q862Z3 UROM_CANFA 1.00E-06 GO:0031225; GO:0016324; GO:0016323; GO:0005509; GO:0060170; GO:0005576; GO:0072372; GO:0000922 anchored to membrane; apical plasma membrane; basolateral plasma membrane; calcium ion binding; cilium membrane; extracellular region; primary cilium; spindle pole IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR023413; IPR009030; IPR001507; IPR017977; "Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]" UMOD Canis familiaris (Dog) (Canis lupus familiaris) TR43711_c0_g1_i1 Q8TEQ6 GEMI5_HUMAN 3.00E-40 GO:0097504; GO:0005829; GO:0034660; GO:0016604; GO:0006461; GO:0017069; GO:0005681; GO:0000387 P06730; Q16637; P62304 Gemini of coiled bodies; cytosol; ncRNA metabolic process; nuclear body; protein complex assembly; snRNA binding; spliceosomal complex; spliceosomal snRNP assembly IPR020472; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; Gem-associated protein 5 (Gemin5) GEMIN5 Homo sapiens (Human) TR43736_c0_g1_i1 Q8TBF5 PIGX_HUMAN 2.00E-16 GO:0006501; GO:0005789; GO:0016021; GO:0016254 C-terminal protein lipidation; endoplasmic reticulum membrane; integral to membrane; preassembly of GPI anchor in ER membrane IPR013233; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. Phosphatidylinositol-glycan biosynthesis class X protein (PIG-X) PIGX Homo sapiens (Human) TR43754_c0_g1_i1 P48159 RL23_DROME 6.00E-77 GO:0000022; GO:0022008; GO:0005840; GO:0003735; GO:0006412 mitotic spindle elongation; neurogenesis; ribosome; structural constituent of ribosome; translation IPR019972; IPR023571; IPR000218; 60S ribosomal protein L23 (L17A) RpL23 RpL17A CG3661 Drosophila melanogaster (Fruit fly) TR43755_c0_g1_i1 P42325 NCAH_DROME 3.00E-06 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Neurocalcin homolog (DrosNCa) Nca CG7641 Drosophila melanogaster (Fruit fly) TR43758_c0_g1_i1 P23381 SYWC_HUMAN 3.00E-24 GO:0005524; GO:0001525; GO:0005829; GO:0008285; GO:0045765; GO:0004830; GO:0006436 ATP binding; angiogenesis; cytosol; negative regulation of cell proliferation; regulation of angiogenesis; tryptophan-tRNA ligase activity; tryptophanyl-tRNA aminoacylation IPR001412; IPR002305; IPR014729; IPR009068; IPR002306; IPR000738; "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" WARS IFI53 WRS Homo sapiens (Human) TR43787_c0_g1_i1 Q503M4 MT12B_DANRE 2.00E-14 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12-B (MCT 12-B) (Solute carrier family 16 member 12-B) slc16a12b slc16a12 zgc:110441 Danio rerio (Zebrafish) (Brachydanio rerio) TR43791_c0_g1_i1 P0DKM0 COA3_DROME 3.00E-09 GO:0016021; GO:0031966 integral to membrane; mitochondrial membrane IPR018628; "Cytochrome c oxidase assembly protein 3, mitochondrial (Coiled-coil domain-containing protein 56 homolog)" Ccdc56 CG42630 Drosophila melanogaster (Fruit fly) TR4380_c0_g1_i1 Q9I927 FUCL5_ANGJA 5.00E-16 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-5 Anguilla japonica (Japanese eel) TR43805_c0_g1_i1 Q0P4M4 CBPC2_XENTR 3.00E-30 GO:0005829; GO:0004181; GO:0006508; GO:0008270 cytosol; metallocarboxypeptidase activity; proteolysis; zinc ion binding IPR000834; Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) agbl2 ccp2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR43823_c0_g1_i1 P83565 RM40_RAT 4.00E-12 GO:0005761 mitochondrial ribosome IPR019192; "39S ribosomal protein L40, mitochondrial (L40mt) (MRP-L40)" Mrpl40 Rattus norvegicus (Rat) TR43832_c0_g1_i1 Q5RBK0 GIN1_PONAB 3.00E-06 GO:0015074; GO:0003676 DNA integration; nucleic acid binding IPR001584; IPR012337; IPR015416; Gypsy retrotransposon integrase-like protein 1 (GIN-1) GIN1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR43846_c0_g1_i1 O00567 NOP56_HUMAN 2.00E-14 GO:0031428; GO:0008219; GO:0005737; GO:0070761; GO:0006364; GO:0030515 box C/D snoRNP complex; cell death; cytoplasm; pre-snoRNP complex; rRNA processing; snoRNA binding IPR012974; IPR002687; IPR012976; Nucleolar protein 56 (Nucleolar protein 5A) NOP56 NOL5A Homo sapiens (Human) TR43879_c0_g1_i1 P18537 FRIZ_DROME 5.00E-06 GO:0004930; GO:0007186; GO:0030165; GO:0007464; GO:0042813; GO:0017147; GO:0008356; GO:0008105; GO:0048675; GO:0007298; GO:0007420; GO:0060070; GO:0005938; GO:0009790; GO:0045198; GO:0008406; GO:0007507; GO:0007156; GO:0035320; GO:0005887; GO:0032589; GO:0016318; GO:0032231; GO:0035206; GO:0035159; GO:0007435; GO:0016360; GO:0001944 Q9V5N8 "G-protein coupled receptor activity; G-protein coupled receptor signaling pathway; PDZ domain binding; R3/R4 cell fate commitment; Wnt-activated receptor activity; Wnt-protein binding; asymmetric cell division; asymmetric protein localization; axon extension; border follicle cell migration; brain development; canonical Wnt receptor signaling pathway; cell cortex; embryo development; establishment of epithelial cell apical/basal polarity; gonad development; heart development; homophilic cell adhesion; imaginal disc-derived wing hair site selection; integral to plasma membrane; neuron projection membrane; ommatidial rotation; regulation of actin filament bundle assembly; regulation of hemocyte proliferation; regulation of tube length, open tracheal system; salivary gland morphogenesis; sensory organ precursor cell fate determination; vasculature development" IPR000539; IPR015526; IPR020067; IPR017981; Frizzled (Frizzled-1) (dFz1) fz CG17697 Drosophila melanogaster (Fruit fly) TR4389_c0_g1_i1 Q9GKW8 AND1A_MACFA 6.00E-13 GO:0007165 signal transduction IPR002110; IPR020683; IPR011029; IPR000488; Ankyrin repeat and death domain-containing protein 1A (Fragment) ANKDD1A QccE-18247 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR43909_c0_g1_i1 Q95WA0 RL26_LITLI 4.00E-52 GO:0015934; GO:0003735; GO:0006412 large ribosomal subunit; structural constituent of ribosome; translation IPR005824; IPR014722; IPR005825; IPR005756; IPR008991; 60S ribosomal protein L26 RPL26 Littorina littorea (Common periwinkle) TR43926_c0_g1_i1 Q2NKQ1 SGSM1_HUMAN 2.00E-36 GO:0005794; GO:0005097; GO:0032851 Golgi apparatus; Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; IPR004012; Small G protein signaling modulator 1 (RUN and TBC1 domain-containing protein 2) SGSM1 KIAA1941 RUTBC2 Homo sapiens (Human) TR43961_c0_g1_i1 Q9W6F8 WIF1_XENLA 3.00E-13 GO:0016055; GO:0005576; GO:0007275 Wnt receptor signaling pathway; extracellular region; multicellular organismal development IPR000742; IPR013032; IPR003306; IPR013309; Wnt inhibitory factor 1 (WIF-1) wif1 Xenopus laevis (African clawed frog) TR43963_c0_g1_i1 Q9V5N8 STAN_DROME 2.00E-12 GO:0004930; GO:0007464; GO:0048057; GO:0016055; GO:0007411; GO:0005509; GO:0016339; GO:0050839; GO:0005911; GO:0048813; GO:0070593; GO:0007156; GO:0005887; GO:0016319; GO:0030178; GO:0007218; GO:0016318; GO:0030177; GO:0005057; GO:0050770; GO:0090175; GO:0051963; GO:0035159; GO:0007367; GO:0004888 P18537 "G-protein coupled receptor activity; R3/R4 cell fate commitment; R3/R4 development; Wnt receptor signaling pathway; axon guidance; calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; cell-cell junction; dendrite morphogenesis; dendrite self-avoidance; homophilic cell adhesion; integral to plasma membrane; mushroom body development; negative regulation of Wnt receptor signaling pathway; neuropeptide signaling pathway; ommatidial rotation; positive regulation of Wnt receptor signaling pathway; receptor signaling protein activity; regulation of axonogenesis; regulation of establishment of planar polarity; regulation of synapse assembly; regulation of tube length, open tracheal system; segment polarity determination; transmembrane signaling receptor activity" IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR001881; IPR013032; IPR002049; IPR017981; IPR001879; IPR000832; IPR000203; IPR001791; Protocadherin-like wing polarity protein stan (Protein flamingo) (Protein starry night) stan fmi CG11895 Drosophila melanogaster (Fruit fly) TR43969_c0_g1_i1 A2AN08 UBR4_MOUSE 1.00E-23 GO:0005737; GO:0005856; GO:0016021; GO:0005634; GO:0042787; GO:0004842; GO:0008270 P06933 cytoplasm; cytoskeleton; integral to membrane; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR016024; IPR025704; IPR017986; IPR003126; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UBR4 (EC 6.3.2.-) (N-recognin-4) (Zinc finger UBR1-type protein 1) (p600) Ubr4 Kiaa0462 Zubr1 Mus musculus (Mouse) TR43971_c0_g1_i1 Q767L8 MDC1_PIG 2.00E-06 GO:0006281; GO:0007049; GO:0005694; GO:0005634 DNA repair; cell cycle; chromosome; nucleus IPR001357; IPR000253; IPR008984; Mediator of DNA damage checkpoint protein 1 MDC1 Sus scrofa (Pig) TR43979_c0_g1_i1 Q8R151 ZNFX1_MOUSE 1.00E-15 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR44020_c0_g2_i1 O94111 DYL1_EMENI 3.00E-14 GO:0030029; GO:0048315; GO:0005868; GO:0005874; GO:0003774; GO:0030473; GO:0005643; GO:0051292; GO:0005777; GO:0043935 actin filament-based process; conidium formation; cytoplasmic dynein complex; microtubule; motor activity; nuclear migration along microtubule; nuclear pore; nuclear pore complex assembly; peroxisome; sexual sporulation resulting in formation of a cellular spore IPR019763; IPR001372; "Dynein light chain, cytoplasmic (8 kDa cytoplasmic dynein light chain)" nudG AN0420 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR44034_c0_g1_i1 Q5T6X4 F162B_HUMAN 4.00E-07 GO:0016021 integral to membrane IPR009432; Protein FAM162B FAM162B C6orf189 Homo sapiens (Human) TR44034_c0_g2_i1 Q2NKR7 F162A_BOVIN 4.00E-07 GO:0006919; GO:0071456; GO:0016021; GO:0005739; GO:0051402; GO:0043065; GO:0090200; GO:0006927 activation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to hypoxia; integral to membrane; mitochondrion; neuron apoptotic process; positive regulation of apoptotic process; positive regulation of release of cytochrome c from mitochondria; transformed cell apoptotic process IPR009432; Protein FAM162A (E2-induced gene 5 protein homolog) FAM162A E2IG5 Bos taurus (Bovine) TR44039_c0_g1_i1 Q1ZXD6 ROCO5_DICDI 2.00E-06 GO:0005524; GO:0005525; GO:0005089; GO:0005622; GO:0005543; GO:0004674; GO:0035023; GO:0007264; GO:0030587 ATP binding; GTP binding; Rho guanyl-nucleotide exchange factor activity; intracellular; phospholipid binding; protein serine/threonine kinase activity; regulation of Rho protein signal transduction; small GTPase mediated signal transduction; sorocarp development IPR000219; IPR011009; IPR001611; IPR025875; IPR003591; IPR013684; IPR027417; IPR011993; IPR001849; IPR000719; IPR017441; IPR020859; IPR001245; IPR008271; IPR001806; Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) TR44041_c0_g1_i1 Q5RCR5 SUMF2_PONAB 3.00E-80 GO:0005788; GO:0046872 endoplasmic reticulum lumen; metal ion binding IPR016187; IPR005532; Sulfatase-modifying factor 2 (C-alpha-formylglycine-generating enzyme 2) SUMF2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR4405_c0_g1_i1 E1BP74 MARF1_BOVIN 2.00E-09 GO:0003723; GO:0030154; GO:0007143; GO:0010923; GO:0000166; GO:0048477; GO:0005777; GO:0010468 RNA binding; cell differentiation; female meiosis; negative regulation of phosphatase activity; nucleotide binding; oogenesis; peroxisome; regulation of gene expression IPR024582; IPR024768; IPR012677; IPR021139; IPR025605; IPR000504; Meiosis arrest female protein 1 (Limkain-b1) MARF1 LKAP Bos taurus (Bovine) TR4407_c0_g2_i1 P08991 H2AV_STRPU 1.00E-65 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR002119; Histone H2A.V (H2A.F/Z) (Fragment) H2A.F/Z Strongylocentrotus purpuratus (Purple sea urchin) TR44108_c0_g1_i1 P18172 DHGL_DROPS 2.00E-16 GO:0006066; GO:0008812; GO:0005576; GO:0050660 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR44111_c0_g1_i1 Q25532 VATG_MANSE 3.00E-40 GO:0016324; GO:0016820; GO:0015992; GO:0016471 "apical plasma membrane; hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances; proton transport; vacuolar proton-transporting V-type ATPase complex" IPR005124; V-type proton ATPase subunit G (V-ATPase subunit G) (V-ATPase 13 kDa subunit) (Vacuolar proton pump subunit G) Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) TR44141_c0_g1_i1 Q556M4 C5082_DICDI 1.00E-07 GO:0020037; GO:0016021; GO:0005506; GO:0004497; GO:0016705 "heme binding; integral to membrane; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" IPR001128; IPR017972; IPR002401; Probable cytochrome P450 508A2 (EC 1.14.-.-) cyp508A2-1 DDB_G0272604; cyp508A2-2 DDB_G0273945 Dictyostelium discoideum (Slime mold) TR44167_c0_g1_i1 Q8HY11 CLC4M_HYLSY 5.00E-11 GO:0006897; GO:0045087; GO:0016021; GO:0005537; GO:0046872 endocytosis; innate immune response; integral to membrane; mannose binding; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (CD antigen CD299) CLEC4M CD209L1 Hylobates syndactylus (Siamang) (Symphalangus syndactylus) TR44181_c0_g1_i1 P54802 ANAG_HUMAN 1.00E-35 GO:0004561; GO:0005975; GO:0021680; GO:0006027; GO:0060119; GO:0045475; GO:0043202; GO:0007040; GO:0042474; GO:0007399; GO:0046548; GO:0044281 alpha-N-acetylglucosaminidase activity; carbohydrate metabolic process; cerebellar Purkinje cell layer development; glycosaminoglycan catabolic process; inner ear receptor cell development; locomotor rhythm; lysosomal lumen; lysosome organization; middle ear morphogenesis; nervous system development; retinal rod cell development; small molecule metabolic process IPR017853; IPR007781; IPR024732; IPR024240; IPR024733; Alpha-N-acetylglucosaminidase (EC 3.2.1.50) (N-acetyl-alpha-glucosaminidase) (NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form] NAGLU UFHSD1 Homo sapiens (Human) TR44183_c0_g1_i1 Q9C005 DPY30_HUMAN 2.00E-32 GO:0005794; GO:0048188; GO:0016197; GO:0051568; GO:0006355; GO:0005802; GO:0006351 Itself; Q9UBL3 "Golgi apparatus; Set1C/COMPASS complex; endosomal transport; histone H3-K4 methylation; regulation of transcription, DNA-dependent; trans-Golgi network; transcription, DNA-dependent" IPR007858; Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L) DPY30 Homo sapiens (Human) TR44186_c0_g1_i1 Q90YP3 RS28_ICTPU 2.00E-26 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR012340; IPR000289; 40S ribosomal protein S28 rps28 Ictalurus punctatus (Channel catfish) (Silurus punctatus) TR4419_c0_g1_i1 Q9Y6J0 CABIN_HUMAN 1.00E-20 GO:0016235; GO:0007166; GO:0016568; GO:0005737; GO:0005634; GO:0004864 aggresome; cell surface receptor signaling pathway; chromatin modification; cytoplasm; nucleus; protein phosphatase inhibitor activity IPR015134; IPR013026; IPR011990; IPR019734; Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) CABIN1 KIAA0330 Homo sapiens (Human) TR44201_c0_g1_i1 P08964 MYO1_YEAST 6.00E-11 GO:0005524; GO:0000916; GO:0005935; GO:0000915; GO:0007109; GO:0000131; GO:0000146; GO:0016460 P53141 "ATP binding; actomyosin contractile ring contraction; cellular bud neck; cytokinesis, actomyosin contractile ring assembly; cytokinesis, completion of separation; incipient cellular bud site; microfilament motor activity; myosin II complex" IPR000048; IPR027401; IPR001609; IPR027417; Myosin-1 (Type II myosin) MYO1 YHR023W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR44206_c0_g1_i1 Q9VCA8 ANKHM_DROME 8.00E-08 GO:0003723; GO:0019730; GO:0051298; GO:0001751; GO:0005811; GO:0043066; GO:0046427; GO:0007169 RNA binding; antimicrobial humoral response; centrosome duplication; compound eye photoreceptor cell differentiation; lipid particle; negative regulation of apoptotic process; positive regulation of JAK-STAT cascade; transmembrane receptor protein tyrosine kinase signaling pathway IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) TR44211_c0_g1_i1 P52742 ZN135_HUMAN 1.00E-29 GO:0003677; GO:0007010; GO:0046872; GO:0005634; GO:0022604; GO:0003700; GO:0006351 "DNA binding; cytoskeleton organization; metal ion binding; nucleus; regulation of cell morphogenesis; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 135 (Zinc finger protein 61) (Zinc finger protein 78-like 1) ZNF135 ZNF61 ZNF78L1 Homo sapiens (Human) TR44232_c0_g1_i1 A6NIV6 LRIQ4_HUMAN 1.00E-20 IPR000048; IPR001611; IPR025875; Leucine-rich repeat and IQ domain-containing protein 4 (Leucine-rich repeat-containing protein 64) LRRIQ4 LRRC64 Homo sapiens (Human) TR44242_c0_g1_i1 P29241 NADA_APLCA 2.00E-19 GO:0003953; GO:0016023; GO:0007338 NAD+ nucleosidase activity; cytoplasmic membrane-bounded vesicle; single fertilization IPR003193; IPR016040; ADP-ribosyl cyclase (ADRC) (EC 3.2.2.5) (NAD glycohydrolase) (NAD(+) nucleosidase) (NADase) Aplysia californica (California sea hare) TR44243_c0_g1_i1 Q54FB7 XDH_DICDI 2.00E-13 GO:0051537; GO:0008762; GO:0009055; GO:0050660; GO:0005506; GO:0043546; GO:0005777; GO:0009115; GO:0004854 "2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; electron carrier activity; flavin adenine dinucleotide binding; iron ion binding; molybdopterin cofactor binding; peroxisome; xanthine catabolic process; xanthine dehydrogenase activity" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; Xanthine dehydrogenase (XD) (EC 1.17.1.4) xdh DDB_G0291047 Dictyostelium discoideum (Slime mold) TR44247_c0_g1_i1 P82915 RT16_BOVIN 6.00E-35 GO:0005763; GO:0003735; GO:0006412 mitochondrial small ribosomal subunit; structural constituent of ribosome; translation IPR000307; IPR023803; "28S ribosomal protein S16, mitochondrial (MRP-S16) (S16mt)" MRPS16 RPMS16 Bos taurus (Bovine) TR44248_c0_g1_i1 Q96A72 MGN2_HUMAN 3.00E-97 GO:0003723; GO:0008380; GO:0006397; GO:0051028; GO:0005634 RNA binding; RNA splicing; mRNA processing; mRNA transport; nucleus IPR004023; Protein mago nashi homolog 2 MAGOHB MAGOH2 Homo sapiens (Human) TR44256_c0_g1_i1 Q00223 XP4_XENLA 2.00E-17 GO:0005576 extracellular region IPR000519; IPR017994; IPR017957; Putative gastrointestinal growth factor xP4 (TFF p4.1) p4 Xenopus laevis (African clawed frog) TR44258_c0_g1_i1 O75179 ANR17_HUMAN 4.00E-14 GO:0003723; GO:0001955; GO:0005737; GO:0019048; GO:0051151; GO:0005634 RNA binding; blood vessel maturation; cytoplasm; modulation by virus of host morphology or physiology; negative regulation of smooth muscle cell differentiation; nucleus IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) TR44263_c0_g2_i1 Q80X19 COEA1_MOUSE 2.00E-08 GO:0007155; GO:0005581; GO:0030199; GO:0048873; GO:0005614; GO:0061050; GO:0003229 cell adhesion; collagen; collagen fibril organization; homeostasis of number of cells within a tissue; interstitial matrix; regulation of cell growth involved in cardiac muscle cell development; ventricular cardiac muscle tissue development IPR008160; IPR008985; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XIV) chain Col14a1 Mus musculus (Mouse) TR44266_c0_g1_i1 Q925C0 SYT9_RAT 9.00E-21 GO:0030054; GO:0031045; GO:0005513; GO:0016021; GO:0046872; GO:0045956; GO:0050796; GO:0030667; GO:0030672; GO:0005215 cell junction; dense core granule; detection of calcium ion; integral to membrane; metal ion binding; positive regulation of calcium ion-dependent exocytosis; regulation of insulin secretion; secretory granule membrane; synaptic vesicle membrane; transporter activity IPR000008; IPR001565; Synaptotagmin-9 (Synaptotagmin 5) (Synaptotagmin IX) (SytIX) (Synaptotagmin V) Syt9 Syt5 Rattus norvegicus (Rat) TR44276_c0_g1_i1 P86854 PLCL_MYTGA 5.00E-14 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR4428_c0_g1_i1 Q0P4F7 ACSF2_DANRE 1.00E-22 GO:0005524; GO:0006631; GO:0016874; GO:0005739 ATP binding; fatty acid metabolic process; ligase activity; mitochondrion IPR025110; IPR020845; IPR000873; "Acyl-CoA synthetase family member 2, mitochondrial (EC 6.2.1.-)" acsf2 zgc:152887 Danio rerio (Zebrafish) (Brachydanio rerio) TR44281_c0_g1_i1 Q6QLW4 CYC_PECGU 6.00E-62 GO:0009055; GO:0020037; GO:0005506; GO:0005758; GO:0055114; GO:0070469 electron carrier activity; heme binding; iron ion binding; mitochondrial intermembrane space; oxidation-reduction process; respiratory chain IPR009056; IPR002327; IPR003088; Cytochrome c Pectinaria gouldii (Trumpet worm) (Ice-cream cone worm) TR44313_c0_g1_i1 Q05546 TENR_RAT 1.00E-14 GO:0007155; GO:0007162; GO:0007399; GO:0005578 cell adhesion; negative regulation of cell adhesion; nervous system development; proteinaceous extracellular matrix IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin-R (TN-R) (Janusin) (Neural recognition molecule J1-160/180) (Restrictin) Tnr Rattus norvegicus (Rat) TR44338_c0_g1_i1 O73746 TIMP3_XENLA 3.00E-09 GO:0046872; GO:0008191; GO:0005578 metal ion binding; metalloendopeptidase inhibitor activity; proteinaceous extracellular matrix IPR001134; IPR001820; IPR008993; IPR027465; IPR015612; Metalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) (TIMP-3) timp3 Xenopus laevis (African clawed frog) TR44340_c0_g1_i1 Q91X17 UROM_MOUSE 2.00E-12 GO:0031225; GO:0016324; GO:0016323; GO:0005509; GO:0048878; GO:0060170; GO:0007588; GO:0005576; GO:0072218; GO:0072221; GO:0072233; GO:0072372; GO:2000021; GO:0000922 anchored to membrane; apical plasma membrane; basolateral plasma membrane; calcium ion binding; chemical homeostasis; cilium membrane; excretion; extracellular region; metanephric ascending thin limb development; metanephric distal convoluted tubule development; metanephric thick ascending limb development; primary cilium; regulation of ion homeostasis; spindle pole IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR023413; IPR009030; IPR001507; IPR017977; "Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]" Umod Mus musculus (Mouse) TR44353_c0_g1_i1 Q61329 ZFHX3_MOUSE 6.00E-19 GO:0005739; GO:0007517; GO:0005634; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "mitochondrion; muscle organ development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR017970; IPR001356; IPR009057; IPR007087; IPR015880; IPR013087; IPR003604; Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) Zfhx3 Atbf1 Mus musculus (Mouse) TR4436_c0_g1_i1 Q3UQ28 PXDN_MOUSE 2.00E-13 GO:0005783; GO:0031012; GO:0030198; GO:0005201; GO:0005615; GO:0020037; GO:0042744; GO:0046872; GO:0004601; GO:0005578 endoplasmic reticulum; extracellular matrix; extracellular matrix organization; extracellular matrix structural constituent; extracellular space; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity; proteinaceous extracellular matrix IPR000483; IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; IPR001007; Peroxidasin homolog (EC 1.11.1.7) Pxdn Kiaa0230 Mus musculus (Mouse) TR4437_c0_g2_i1 P33198 IDHP_PIG 2.00E-125 GO:0006103; GO:0051287; GO:0006097; GO:0004450; GO:0006102; GO:0000287; GO:0005743; GO:0006099 2-oxoglutarate metabolic process; NAD binding; glyoxylate cycle; isocitrate dehydrogenase (NADP+) activity; isocitrate metabolic process; magnesium ion binding; mitochondrial inner membrane; tricarboxylic acid cycle IPR019818; IPR004790; IPR024084; "Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) (Fragment)" IDH2 Sus scrofa (Pig) TR44370_c0_g1_i1 Q5XHM7 CHSTC_XENLA 2.00E-08 GO:0000139; GO:0016051; GO:0047756; GO:0016021 Golgi membrane; carbohydrate biosynthetic process; chondroitin 4-sulfotransferase activity; integral to membrane IPR018011; IPR005331; Carbohydrate sulfotransferase 12 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 2) (Chondroitin 4-sulfotransferase 2) (C4ST-2) (C4ST2) chst12 Xenopus laevis (African clawed frog) TR44374_c0_g1_i1 P41233 ABCA1_MOUSE 3.00E-35 GO:0005524; GO:0006200; GO:0016887; GO:0007186; GO:0005794; GO:0008509; GO:0034188; GO:0071222; GO:0071300; GO:0033344; GO:0042632; GO:0008203; GO:0017127; GO:0016197; GO:0034380; GO:0005887; GO:0050702; GO:0032367; GO:0007040; GO:0045121; GO:0002790; GO:0045335; GO:0006911; GO:0033700; GO:0055091; GO:0045332; GO:0005548; GO:0060155; GO:0030819; GO:0010875; GO:0006497; GO:0032489; GO:0034616; GO:0055098; GO:0043691 "ATP binding; ATP catabolic process; ATPase activity; G-protein coupled receptor signaling pathway; Golgi apparatus; anion transmembrane transporter activity; apolipoprotein A-I receptor activity; cellular response to lipopolysaccharide; cellular response to retinoic acid; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transporter activity; endosomal transport; high-density lipoprotein particle assembly; integral to plasma membrane; interleukin-1 beta secretion; intracellular cholesterol transport; lysosome organization; membrane raft; peptide secretion; phagocytic vesicle; phagocytosis, engulfment; phospholipid efflux; phospholipid homeostasis; phospholipid translocation; phospholipid transporter activity; platelet dense granule organization; positive regulation of cAMP biosynthetic process; positive regulation of cholesterol efflux; protein lipidation; regulation of Cdc42 protein signal transduction; response to laminar fluid shear stress; response to low-density lipoprotein particle stimulus; reverse cholesterol transport" IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) Abca1 Abc1 Mus musculus (Mouse) TR44393_c0_g1_i1 Q8KQN8 CPHE_PSEAG 6.00E-19 GO:0044260; GO:0005576; GO:0006508; GO:0008236 cellular macromolecule metabolic process; extracellular region; proteolysis; serine-type peptidase activity IPR005320; IPR011811; Cyanophycinase (EC 3.4.15.6) (Extracellular CGPase) (CPHEpa) (Extracellular cyanophycinase) cphE Pseudomonas anguilliseptica TR44395_c0_g1_i1 Q92824 PCSK5_HUMAN 3.00E-15 GO:0005796; GO:0009952; GO:0007267; GO:0042089; GO:0007566; GO:0048566; GO:0048706; GO:0012505; GO:0005615; GO:0007507; GO:0016021; GO:0001822; GO:0035108; GO:0032455; GO:0048011; GO:0042277; GO:0043043; GO:0006508; GO:0002001; GO:0030323; GO:0030141; GO:0004252; GO:0006465; GO:0019058 Golgi lumen; anterior/posterior pattern specification; cell-cell signaling; cytokine biosynthetic process; embryo implantation; embryonic digestive tract development; embryonic skeletal system development; endomembrane system; extracellular space; heart development; integral to membrane; kidney development; limb morphogenesis; nerve growth factor processing; neurotrophin TRK receptor signaling pathway; peptide binding; peptide biosynthetic process; proteolysis; renin secretion into blood stream; respiratory tube development; secretory granule; serine-type endopeptidase activity; signal peptide processing; viral life cycle IPR000742; IPR006212; IPR008979; IPR009030; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5) PCSK5 PC5 PC6 Homo sapiens (Human) TR44402_c0_g1_i1 Q80YA8 CRUM2_MOUSE 1.00E-20 GO:0005509; GO:0016021; GO:0050896 calcium ion binding; integral to membrane; response to stimulus IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protein crumbs homolog 2 (Crumbs-like protein 2) Crb2 Mus musculus (Mouse) TR44402_c0_g2_i1 P10079 FBP1_STRPU 7.00E-29 GO:0032579; GO:0005509; GO:0016023; GO:0005615 apical lamina of hyaline layer; calcium ion binding; cytoplasmic membrane-bounded vesicle; extracellular space IPR005469; IPR017889; IPR005468; IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) TR44406_c0_g1_i1 Q62232 SIX2_MOUSE 7.00E-44 GO:0008283; GO:0002062; GO:0048701; GO:0003337; GO:0007501; GO:0042474; GO:0045596; GO:0005634; GO:0045944; GO:0032403; GO:0006606; GO:0043565; GO:0003700 P97767 cell proliferation; chondrocyte differentiation; embryonic cranial skeleton morphogenesis; mesenchymal to epithelial transition involved in metanephros morphogenesis; mesodermal cell fate specification; middle ear morphogenesis; negative regulation of cell differentiation; nucleus; positive regulation of transcription from RNA polymerase II promoter; protein complex binding; protein import into nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR017970; IPR001356; IPR009057; Homeobox protein SIX2 (Sine oculis homeobox homolog 2) Six2 Mus musculus (Mouse) TR44419_c0_g1_i1 Q5H8A4 PIGG_HUMAN 5.00E-20 GO:0006501; GO:0051267; GO:0005789; GO:0016021; GO:0016254 C-terminal protein lipidation; CP2 mannose-ethanolamine phosphotransferase activity; endoplasmic reticulum membrane; integral to membrane; preassembly of GPI anchor in ER membrane IPR017849; IPR017850; IPR002591; Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (GPI7 homolog) (hGPI7) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G) PIGG GPI7 UNQ1930/PRO4405 Homo sapiens (Human) TR44432_c0_g1_i1 Q9Y493 ZAN_HUMAN 8.00E-10 GO:0007339; GO:0016337; GO:0016021; GO:0005886 binding of sperm to zona pellucida; cell-cell adhesion; integral to membrane; plasma membrane IPR008985; IPR000742; IPR013032; IPR000998; IPR002919; IPR025615; IPR014853; IPR001007; IPR001846; Zonadhesin ZAN Homo sapiens (Human) TR44439_c0_g1_i1 A2AV25 FBCD1_MOUSE 4.00E-08 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 Fibcd1 Mus musculus (Mouse) TR4451_c0_g1_i1 Q4LDE5 SVEP1_HUMAN 2.00E-18 GO:0005509; GO:0007155; GO:0003682; GO:0005737; GO:0005576; GO:0016020 calcium ion binding; cell adhesion; chromatin binding; cytoplasm; extracellular region; membrane IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023413; IPR009030; IPR003410; IPR001759; IPR000436; IPR011641; IPR002035; "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) TR4455_c0_g1_i1 O15164 TIF1A_HUMAN 9.00E-06 GO:0055074; GO:0071391; GO:0003682; GO:0005829; GO:0034056; GO:0070577; GO:0008285; GO:0045892; GO:0005719; GO:0005634; GO:0005726; GO:0045893; GO:0046777; GO:0030163; GO:0004672; GO:0005102; GO:0042981; GO:0031647; GO:0070562; GO:0043565; GO:0003713; GO:0006366; GO:0004842; GO:0008270 "calcium ion homeostasis; cellular response to estrogen stimulus; chromatin binding; cytosol; estrogen response element binding; histone acetyl-lysine binding; negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; nuclear euchromatin; nucleus; perichromatin fibrils; positive regulation of transcription, DNA-dependent; protein autophosphorylation; protein catabolic process; protein kinase activity; receptor binding; regulation of apoptotic process; regulation of protein stability; regulation of vitamin D receptor signaling pathway; sequence-specific DNA binding; transcription coactivator activity; transcription from RNA polymerase II promoter; ubiquitin-protein ligase activity; zinc ion binding" IPR003649; IPR001487; IPR018359; IPR019786; IPR000315; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (Tripartite motif-containing protein 24) TRIM24 RNF82 TIF1 TIF1A Homo sapiens (Human) TR4461_c0_g1_i1 P78413 IRX4_HUMAN 9.00E-28 GO:0048561; GO:0007507; GO:0005634; GO:0043565; GO:0003700 establishment of organ orientation; heart development; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR017970; IPR001356; IPR008422; IPR009057; IPR003893; Iroquois-class homeodomain protein IRX-4 (Homeodomain protein IRXA3) (Iroquois homeobox protein 4) IRX4 IRXA3 Homo sapiens (Human) TR4483_c0_g1_i1 P14248 RPB1_PLAFD 2.00E-06 GO:0003677; GO:0005665; GO:0003899; GO:0046872; GO:0006366 "DNA binding; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase activity; metal ion binding; transcription from RNA polymerase II promoter" IPR000722; IPR000684; IPR006592; IPR007080; IPR007066; IPR007083; IPR007081; IPR007075; IPR007073; DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) RPII Plasmodium falciparum (isolate CDC / Honduras) TR4494_c0_g1_i1 O43301 HS12A_HUMAN 1.00E-09 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR4497_c0_g1_i1 Q8VI93 OAS3_MOUSE 5.00E-11 GO:0001730; GO:0005524; GO:0005737; GO:0051607; GO:0003725; GO:0045087; GO:0046872; GO:0045071; GO:0005634; GO:0060700; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; cytoplasm; defense response to virus; double-stranded RNA binding; innate immune response; metal ion binding; negative regulation of viral genome replication; nucleus; regulation of ribonuclease activity; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; "2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (2',5'-oligoadenylate synthetase-like 10)" Oas3 oasl10 Mus musculus (Mouse) TR4497_c0_g2_i1 G3V645 OASL1_RAT 1.00E-09 GO:0005524; GO:0003677; GO:0005737; GO:0051607; GO:0003725; GO:0045087; GO:0045071; GO:0005730; GO:0009615; GO:0016740 ATP binding; DNA binding; cytoplasm; defense response to virus; double-stranded RNA binding; innate immune response; negative regulation of viral genome replication; nucleolus; response to virus; transferase activity IPR006117; IPR006116; IPR018952; IPR026774; IPR000626; 2'-5'-oligoadenylate synthase-like protein 1 Oasl Rattus norvegicus (Rat) TR4497_c1_g1_i1 P11928 OAS1A_MOUSE 3.00E-09 GO:0001730; GO:0005524; GO:0051607; GO:0003725; GO:0005783; GO:0045087; GO:0046872; GO:0005739; GO:0005634; GO:0006164; GO:0009615 2'-5'-oligoadenylate synthetase activity; ATP binding; defense response to virus; double-stranded RNA binding; endoplasmic reticulum; innate immune response; metal ion binding; mitochondrion; nucleus; purine nucleotide biosynthetic process; response to virus IPR006117; IPR006116; IPR018952; IPR026774; IPR002934; 2'-5'-oligoadenylate synthase 1A ((2-5')oligo(A) synthase 1A) (2-5A synthase 1A) (EC 2.7.7.84) (p42 OAS) Oas1a Oias1 Mus musculus (Mouse) TR4499_c1_g1_i1 P50580 PA2G4_MOUSE 1.00E-14 GO:0003677; GO:0003723; GO:0005737; GO:0045892; GO:0005730; GO:0005634; GO:0006364; GO:0006417; GO:0030529; GO:0003700; GO:0006351 "DNA binding; RNA binding; cytoplasm; negative regulation of transcription, DNA-dependent; nucleolus; nucleus; rRNA processing; regulation of translation; ribonucleoprotein complex; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004545; IPR000994; IPR018349; IPR011991; Proliferation-associated protein 2G4 (IRES-specific cellular trans-acting factor 45 kDa) (ITAF45) (Mpp1) (Proliferation-associated protein 1) (Protein p38-2G4) Pa2g4 Ebp1 Plfap Mus musculus (Mouse) TR4500_c0_g1_i1 O94111 DYL1_EMENI 3.00E-08 GO:0030029; GO:0048315; GO:0005868; GO:0005874; GO:0003774; GO:0030473; GO:0005643; GO:0051292; GO:0005777; GO:0043935 actin filament-based process; conidium formation; cytoplasmic dynein complex; microtubule; motor activity; nuclear migration along microtubule; nuclear pore; nuclear pore complex assembly; peroxisome; sexual sporulation resulting in formation of a cellular spore IPR019763; IPR001372; "Dynein light chain, cytoplasmic (8 kDa cytoplasmic dynein light chain)" nudG AN0420 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR4507_c0_g1_i1 Q9P2D8 UNC79_HUMAN 2.00E-16 GO:0048149; GO:0016021; GO:0034220; GO:0035264; GO:0005886 behavioral response to ethanol; integral to membrane; ion transmembrane transport; multicellular organism growth; plasma membrane IPR016024; IPR024855; Protein unc-79 homolog UNC79 KIAA1409 Homo sapiens (Human) TR4508_c0_g1_i1 P05504 ATP6_RAT 8.00E-88 GO:0015986; GO:0007568; GO:0015078; GO:0016021; GO:0005753; GO:0045263; GO:0055093 "ATP synthesis coupled proton transport; aging; hydrogen ion transmembrane transporter activity; integral to membrane; mitochondrial proton-transporting ATP synthase complex; proton-transporting ATP synthase complex, coupling factor F(o); response to hyperoxia" IPR000568; IPR023011; ATP synthase subunit a (F-ATPase protein 6) Mt-atp6 Atp6 Atpase6 Mtatp6 Rattus norvegicus (Rat) TR4518_c0_g1_i1 P23935 NDUA5_BOVIN 1.00E-38 GO:0005747; GO:0016651; GO:0022904 "mitochondrial respiratory chain complex I; oxidoreductase activity, acting on NAD(P)H; respiratory electron transport chain" IPR006806; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (Complex I subunit B13) (Complex I-13kD-B) (CI-13kD-B) (NADH-ubiquinone oxidoreductase 13 kDa-B subunit) NDUFA5 Bos taurus (Bovine) TR453_c0_g1_i1 P54802 ANAG_HUMAN 8.00E-10 GO:0004561; GO:0005975; GO:0021680; GO:0006027; GO:0060119; GO:0045475; GO:0043202; GO:0007040; GO:0042474; GO:0007399; GO:0046548; GO:0044281 alpha-N-acetylglucosaminidase activity; carbohydrate metabolic process; cerebellar Purkinje cell layer development; glycosaminoglycan catabolic process; inner ear receptor cell development; locomotor rhythm; lysosomal lumen; lysosome organization; middle ear morphogenesis; nervous system development; retinal rod cell development; small molecule metabolic process IPR017853; IPR007781; IPR024732; IPR024240; IPR024733; Alpha-N-acetylglucosaminidase (EC 3.2.1.50) (N-acetyl-alpha-glucosaminidase) (NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form] NAGLU UFHSD1 Homo sapiens (Human) TR4530_c0_g1_i1 Q27274 RO60_CAEEL 4.00E-06 GO:0003723; GO:0005737; GO:0046872; GO:0030529 RNA binding; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein homolog rop-1 C12D8.11 Caenorhabditis elegans TR4532_c0_g1_i1 A0KG16 MDH_AERHH 1.00E-39 GO:0030060; GO:0044262; GO:0006108; GO:0006099 L-malate dehydrogenase activity; cellular carbohydrate metabolic process; malate metabolic process; tricarboxylic acid cycle IPR001557; IPR022383; IPR001236; IPR015955; IPR001252; IPR010097; IPR023958; IPR016040; Malate dehydrogenase (EC 1.1.1.37) mdh AHA_0659 Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) TR4534_c0_g1_i1 Q9VHI4 SF3B5_DROME 9.00E-49 GO:0000398; GO:0007052; GO:0071011 Q9VDK2 "mRNA splicing, via spliceosome; mitotic spindle organization; precatalytic spliceosome" IPR009846; IPR017089; Probable splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit) CG11985 Drosophila melanogaster (Fruit fly) TR4536_c0_g1_i1 Q7ZU92 PARN_DANRE 7.00E-26 GO:0003723; GO:0005737; GO:0006402; GO:0046872; GO:0090305; GO:0000166; GO:0005634; GO:0004535 RNA binding; cytoplasm; mRNA catabolic process; metal ion binding; nucleic acid phosphodiester bond hydrolysis; nucleotide binding; nucleus; poly(A)-specific ribonuclease activity IPR012677; IPR014789; IPR001374; IPR006941; IPR012337; Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Polyadenylate-specific ribonuclease) parn zgc:56067 Danio rerio (Zebrafish) (Brachydanio rerio) TR4546_c0_g1_i1 Q60673 PTPRN_MOUSE 2.00E-34 GO:0016021; GO:0005886; GO:0004725; GO:0000302; GO:0007185 P18052; P80560 integral to membrane; plasma membrane; protein tyrosine phosphatase activity; response to reactive oxygen species; transmembrane receptor protein tyrosine phosphatase signaling pathway IPR021613; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (PTP IA-2) Ptprn Ptp35 Mus musculus (Mouse) TR4546_c0_g2_i1 Q62130 PTN14_MOUSE 1.00E-07 GO:0005737; GO:0005856; GO:0001946; GO:0008285; GO:0005634; GO:0004725; GO:0046825; GO:0006355; GO:0003712; GO:0006351 "cytoplasm; cytoskeleton; lymphangiogenesis; negative regulation of cell proliferation; nucleus; protein tyrosine phosphatase activity; regulation of protein export from nucleus; regulation of transcription, DNA-dependent; transcription cofactor activity; transcription, DNA-dependent" IPR019749; IPR019750; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; IPR000387; IPR016130; IPR014392; IPR000242; Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36) Ptpn14 Mus musculus (Mouse) TR4557_c0_g1_i1 Q9HCF6 TRPM3_HUMAN 2.00E-09 GO:0005262; GO:0005261; GO:0016021 calcium channel activity; cation channel activity; integral to membrane IPR005821; Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) TRPM3 KIAA1616 LTRPC3 Homo sapiens (Human) TR4577_c0_g1_i1 Q9QZH2 BARD1_RAT 2.00E-09 GO:0031436; GO:0006281; GO:0005737; GO:0016874; GO:0043066; GO:0046826; GO:0043065; GO:0085020; GO:0042803; GO:0042325; GO:0007283; GO:0008270 BRCA1-BARD1 complex; DNA repair; cytoplasm; ligase activity; negative regulation of apoptotic process; negative regulation of protein export from nucleus; positive regulation of apoptotic process; protein K6-linked ubiquitination; protein homodimerization activity; regulation of phosphorylation; spermatogenesis; zinc ion binding IPR002110; IPR020683; IPR001357; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. BRCA1-associated RING domain protein 1 (BARD-1) (EC 6.3.2.-) Bard1 Rattus norvegicus (Rat) TR4578_c0_g1_i1 Q812A3 ANR23_MOUSE 1.00E-10 GO:0031674; GO:0015629; GO:0006631; GO:0005634 I band; actin cytoskeleton; fatty acid metabolic process; nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) Ankrd23 Darp Mus musculus (Mouse) TR4580_c0_g1_i1 Q7Z412 PEX26_HUMAN 3.00E-14 GO:0005779; GO:0005777; GO:0032403; GO:0016558; GO:0045046 P40855; Q9UMX1 integral to peroxisomal membrane; peroxisome; protein complex binding; protein import into peroxisome matrix; protein import into peroxisome membrane IPR010797; Peroxisome assembly protein 26 (Peroxin-26) PEX26 Homo sapiens (Human) TR46_c0_g1_i1 Q28178 TSP1_BOVIN 4.00E-15 GO:0048266; GO:0005509; GO:0007155; GO:0005576; GO:0008201; GO:0034976; GO:0016529 behavioral response to pain; calcium ion binding; cell adhesion; extracellular region; heparin binding; response to endoplasmic reticulum stress; sarcoplasmic reticulum IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR001791; IPR000884; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-1 THBS1 TSP-1 TSP1 Bos taurus (Bovine) TR4622_c0_g1_i1 Q5DRB2 PCDG8_PANTR 2.00E-08 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR013164; Protocadherin gamma-A8 (PCDH-gamma-A8) PCDHGA8 Pan troglodytes (Chimpanzee) TR4635_c0_g1_i1 Q7T3T2 CALM_EPIAK 9.00E-23 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) calm cal1 Epinephelus akaara (Hong Kong grouper) (Serranus akaara) TR4637_c0_g1_i1 Q13490 BIRC2_HUMAN 1.00E-15 GO:0035631; GO:0038061; GO:0035666; GO:0007166; GO:0006921; GO:0005829; GO:0045087; GO:0009898; GO:0070266; GO:0043066; GO:0005634; GO:0001890; GO:0043123; GO:0043161; GO:0000209; GO:0039535; GO:0051726; GO:0045595; GO:0042127; GO:2000116; GO:0050727; GO:0060544; GO:0070424; GO:0034121; GO:0006355; GO:0034138; GO:0034142; GO:0003713; GO:0006351; GO:0004842; GO:0008270 P55210; Q9NR28; P63000; Q13546; O43353; Q9Y572; P57078; Q9NP84; Q12933 "CD40 receptor complex; NIK/NF-kappaB cascade; TRIF-dependent toll-like receptor signaling pathway; cell surface receptor signaling pathway; cellular component disassembly involved in execution phase of apoptosis; cytosol; innate immune response; internal side of plasma membrane; necroptosis; negative regulation of apoptotic process; nucleus; placenta development; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of RIG-I signaling pathway; regulation of cell cycle; regulation of cell differentiation; regulation of cell proliferation; regulation of cysteine-type endopeptidase activity; regulation of inflammatory response; regulation of necroptosis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of toll-like receptor signaling pathway; regulation of transcription, DNA-dependent; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; transcription coactivator activity; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (IAP-2) (hIAP-2) (hIAP2) (RING finger protein 48) (TNFR2-TRAF-signaling complex protein 2) BIRC2 API1 IAP2 MIHB RNF48 Homo sapiens (Human) TR4639_c0_g1_i1 A6NK53 ZN233_HUMAN 8.00E-21 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 233 ZNF233 Homo sapiens (Human) TR4642_c0_g1_i1 A5D7M3 GAS8_BOVIN 2.00E-29 GO:0005794; GO:0048870; GO:0005874; GO:0005932; GO:0031514 Golgi apparatus; cell motility; microtubule; microtubule basal body; motile cilium IPR025593; Growth arrest-specific protein 8 (GAS-8) GAS8 Bos taurus (Bovine) TR4650_c1_g1_i1 P10394 POL4_DROME 9.00E-16 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR4654_c0_g1_i1 Q5EAJ7 MVP_STRPU 7.00E-49 GO:0005737; GO:0005634; GO:0030529 cytoplasm; nucleus; ribonucleoprotein complex IPR000048; IPR021870; IPR002499; Major vault protein (MVP) MVP Strongylocentrotus purpuratus (Purple sea urchin) TR4659_c0_g1_i1 Q91VN0 LRP5_MOUSE 3.00E-08 GO:0044332; GO:0042813; GO:0060612; GO:0060033; GO:0009952; GO:1902262; GO:0048539; GO:0060349; GO:0046849; GO:0060444; GO:0060070; GO:0042074; GO:0060764; GO:0042632; GO:0008203; GO:0015026; GO:0048596; GO:0042733; GO:0060059; GO:0006897; GO:0005783; GO:0035426; GO:0001702; GO:0016021; GO:0005739; GO:0002076; GO:0005886; GO:0033690; GO:0051091; GO:0045944; GO:0043235; GO:0042981; GO:0046850; GO:0045598; GO:0061178; GO:0030278; GO:0061304; GO:0035019 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt-activated receptor activity; adipose tissue development; anatomical structure regression; anterior/posterior pattern specification; apoptotic process involved in patterning of blood vessels; bone marrow development; bone morphogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway; cell migration involved in gastrulation; cell-cell signaling involved in mammary gland development; cholesterol homeostasis; cholesterol metabolic process; coreceptor activity; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic retina morphogenesis in camera-type eye; endocytosis; endoplasmic reticulum; extracellular matrix-cell signaling; gastrulation with mouth forming second; integral to membrane; mitochondrion; osteoblast development; plasma membrane; positive regulation of osteoblast proliferation; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; receptor complex; regulation of apoptotic process; regulation of bone remodeling; regulation of fat cell differentiation; regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of ossification; retinal blood vessel morphogenesis; somatic stem cell maintenance IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7) (Lr3) Lrp5 Lrp7 Mus musculus (Mouse) TR4661_c0_g1_i2 P43235 CATK_HUMAN 9.00E-21 GO:0045453; GO:0030574; GO:0004197; GO:0036021; GO:0022617; GO:0005576; GO:0005615; GO:0045087; GO:0001957; GO:0006508; GO:0002224 bone resorption; collagen catabolic process; cysteine-type endopeptidase activity; endolysosome lumen; extracellular matrix disassembly; extracellular region; extracellular space; innate immune response; intramembranous ossification; proteolysis; toll-like receptor signaling pathway IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR015644; IPR013201; Cathepsin K (EC 3.4.22.38) (Cathepsin O) (Cathepsin O2) (Cathepsin X) CTSK CTSO CTSO2 Homo sapiens (Human) TR4674_c0_g1_i1 Q9EPR4 S23A2_MOUSE 4.00E-13 GO:0008520; GO:0019852; GO:0015882; GO:0016324; GO:0009925; GO:0005737; GO:0005887; GO:0006979; GO:0070890; GO:0070904 L-ascorbate:sodium symporter activity; L-ascorbic acid metabolic process; L-ascorbic acid transport; apical plasma membrane; basal plasma membrane; cytoplasm; integral to plasma membrane; response to oxidative stress; sodium-dependent L-ascorbate transmembrane transporter activity; transepithelial L-ascorbic acid transport IPR006042; IPR006043; Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) (SVCT-2) (mSVCT2) (Yolk sac permease-like molecule 2) Slc23a2 Kiaa0238 Svct2 Yspl2 Mus musculus (Mouse) TR4676_c0_g1_i1 Q14590 ZN235_HUMAN 4.00E-06 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) TR4679_c0_g1_i1 Q6XIM8 RS15A_DROYA 1.00E-78 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000630; 40S ribosomal protein S15a RpS15Aa GE16163 Drosophila yakuba (Fruit fly) TR4686_c0_g1_i1 Q86Z23 C1QL4_HUMAN 2.00E-06 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) C1QL4 CTRP11 Homo sapiens (Human) TR4694_c0_g1_i1 Q5UPG5 YL093_MIMIV 1.00E-10 IPR002110; IPR020683; Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) TR4694_c0_g2_i1 Q6F6B3 TANC1_RAT 2.00E-10 GO:0030054; GO:0014069; GO:0045211 Q9UKE5 cell junction; postsynaptic density; postsynaptic membrane IPR002110; IPR020683; IPR027417; IPR013026; IPR011990; IPR013105; IPR019734; "Protein TANC1 (TPR domain, ankyrin-repeat and coiled-coil domain-containing protein 1)" Tanc1 Tanc Rattus norvegicus (Rat) TR4704_c0_g1_i1 O75093 SLIT1_HUMAN 3.00E-10 GO:0048846; GO:0005509; GO:0005737; GO:0033563; GO:0040023; GO:0005615; GO:0048853; GO:0008045; GO:0050919; GO:0048843; GO:0051964; GO:0031290; GO:0021510; GO:0022028 axon extension involved in axon guidance; calcium ion binding; cytoplasm; dorsal/ventral axon guidance; establishment of nucleus localization; extracellular space; forebrain morphogenesis; motor neuron axon guidance; negative chemotaxis; negative regulation of axon extension involved in axon guidance; negative regulation of synapse assembly; retinal ganglion cell axon guidance; spinal cord development; tangential migration from the subventricular zone to the olfactory bulb IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR003645; IPR009030; IPR001791; IPR001611; IPR025875; IPR003591; IPR000372; Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4) SLIT1 KIAA0813 MEGF4 SLIL1 Homo sapiens (Human) TR4704_c0_g2_i1 Q45R42 LRRC4_RAT 4.00E-13 GO:0030054; GO:0016021; GO:0045211 cell junction; integral to membrane; postsynaptic membrane IPR000483; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; IPR026906; IPR026882; Leucine-rich repeat-containing protein 4 (Netrin-G2 ligand) (NGL-2) Lrrc4 Rattus norvegicus (Rat) TR4713_c0_g1_i1 P78363 ABCA4_HUMAN 5.00E-19 GO:0005524; GO:0042626; GO:0005887; GO:0006649; GO:0004012; GO:0045494; GO:0097381; GO:0007603; GO:0001523; GO:0007601 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; integral to plasma membrane; phospholipid transfer to membrane; phospholipid-translocating ATPase activity; photoreceptor cell maintenance; photoreceptor disc membrane; phototransduction, visible light; retinoid metabolic process; visual perception" IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; IPR005951; Retinal-specific ATP-binding cassette transporter (ATP-binding cassette sub-family A member 4) (RIM ABC transporter) (RIM protein) (RmP) (Stargardt disease protein) ABCA4 ABCR Homo sapiens (Human) TR4714_c0_g1_i1 P28840 NEC1_RAT 2.00E-21 GO:0043679; GO:0030425; GO:0009790; GO:0005615; GO:0043559; GO:0022008; GO:0031016; GO:0016486; GO:0043204; GO:0048471; GO:0021983; GO:0050714; GO:0016540; GO:0006508; GO:0048678; GO:0051592; GO:0010157; GO:0042493; GO:0070542; GO:0051384; GO:0009749; GO:0070555; GO:0032496; GO:0043278; GO:0031667; GO:0043434; GO:0005791; GO:0030141; GO:0004252; GO:0005802; GO:0030133 axon terminus; dendrite; embryo development; extracellular space; insulin binding; neurogenesis; pancreas development; peptide hormone processing; perikaryon; perinuclear region of cytoplasm; pituitary gland development; positive regulation of protein secretion; protein autoprocessing; proteolysis; response to axon injury; response to calcium ion; response to chlorate; response to drug; response to fatty acid; response to glucocorticoid stimulus; response to glucose stimulus; response to interleukin-1; response to lipopolysaccharide; response to morphine; response to nutrient levels; response to peptide hormone stimulus; rough endoplasmic reticulum; secretory granule; serine-type endopeptidase activity; trans-Golgi network; transport vesicle IPR008979; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR022005; IPR009020; IPR002884; Neuroendocrine convertase 1 (NEC 1) (EC 3.4.21.93) (Prohormone convertase 1) (Proprotein convertase 1) (PC1) Pcsk1 Bdp Nec-1 Nec1 Rattus norvegicus (Rat) TR4717_c0_g1_i1 Q5GH73 XKR6_HUMAN 3.00E-14 GO:0016021 integral to membrane IPR018629; XK-related protein 6 XKR6 C8orf21 C8orf5 C8orf7 XRG6 Homo sapiens (Human) TR4718_c0_g1_i1 Q92005 EF1A_DANRE 2.00E-31 GO:0005525; GO:0006184; GO:0003924; GO:0005737; GO:0003746 GTP binding; GTP catabolic process; GTPase activity; cytoplasm; translation elongation factor activity IPR000795; IPR027417; IPR009000; IPR009001; IPR004539; IPR004161; IPR004160; Elongation factor 1-alpha (EF-1-alpha) eef1a ef1a Danio rerio (Zebrafish) (Brachydanio rerio) TR4729_c1_g1_i1 P98160 PGBM_HUMAN 7.00E-08 GO:0005796; GO:0001525; GO:0005605; GO:0007420; GO:0005975; GO:0048738; GO:0060351; GO:0002062; GO:0030204; GO:0048704; GO:0001958; GO:0030198; GO:0005615; GO:0070062; GO:0006024; GO:0006027; GO:0042157; GO:0043202; GO:0046872; GO:0007603; GO:0005886; GO:0008104; GO:0001523 P35968 "Golgi lumen; angiogenesis; basal lamina; brain development; carbohydrate metabolic process; cardiac muscle tissue development; cartilage development involved in endochondral bone morphogenesis; chondrocyte differentiation; chondroitin sulfate metabolic process; embryonic skeletal system morphogenesis; endochondral ossification; extracellular matrix organization; extracellular space; extracellular vesicular exosome; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; lipoprotein metabolic process; lysosomal lumen; metal ion binding; phototransduction, visible light; plasma membrane; protein localization; retinoid metabolic process" IPR008985; IPR013320; IPR000742; IPR013032; IPR002049; IPR007110; IPR013783; IPR013098; IPR003598; IPR018031; IPR000034; IPR001791; IPR023415; IPR002172; IPR000082; Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] HSPG2 Homo sapiens (Human) TR4737_c0_g1_i1 Q7XM31 RDR2_ORYSJ 1.00E-16 GO:0003723; GO:0003968; GO:0031047 RNA binding; RNA-directed RNA polymerase activity; gene silencing by RNA IPR007855; Probable RNA-dependent RNA polymerase 2 (OsRDR2) (EC 2.7.7.48) RDR2 Os04g0465700 LOC_Os04g39160 OSJNBb0048E02.13 Oryza sativa subsp. japonica (Rice) TR4742_c0_g2_i1 O87296 HGPB_HAEIF 1.00E-07 GO:0009279; GO:0016021; GO:0004872; GO:0005215 cell outer membrane; integral to membrane; receptor activity; transporter activity IPR012910; IPR006970; IPR000531; IPR010949; IPR010917; Hemoglobin and hemoglobin-haptoglobin-binding protein B hgpB Haemophilus influenzae TR4751_c0_g1_i1 P20693 FCER2_MOUSE 4.00E-13 GO:0030246; GO:0009897; GO:0016021; GO:0046872; GO:0002925; GO:0051712; GO:0051000; GO:0051770 carbohydrate binding; external side of plasma membrane; integral to membrane; metal ion binding; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of killing of cells of other organism; positive regulation of nitric-oxide synthase activity; positive regulation of nitric-oxide synthase biosynthetic process IPR001304; IPR016186; IPR018378; IPR016187; Low affinity immunoglobulin epsilon Fc receptor (Fc-epsilon-RII) (Lymphocyte IgE receptor) (CD antigen CD23) Fcer2 Fcer2a Mus musculus (Mouse) TR4753_c0_g1_i1 P81282 CSPG2_BOVIN 1.00E-07 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Bos taurus (Bovine) TR4772_c0_g1_i1 Q8R151 ZNFX1_MOUSE 6.00E-12 GO:0046872 metal ion binding IPR027417; NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) TR4790_c0_g1_i1 Q6NX28 LRC59_XENTR 2.00E-11 GO:0005789; GO:0016021; GO:0005635 endoplasmic reticulum membrane; integral to membrane; nuclear envelope IPR001611; Leucine-rich repeat-containing protein 59 lrrc59 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR4804_c0_g1_i1 Q9QYP1 LRP4_RAT 4.00E-08 GO:0016055; GO:0005509; GO:0030154; GO:0009953; GO:0042733; GO:0006897; GO:0001942; GO:0016021; GO:0001822; GO:0090090; GO:0030279; GO:0042475; GO:0005886; GO:0009954; GO:0043113; GO:0001932; GO:0051124 Wnt receptor signaling pathway; calcium ion binding; cell differentiation; dorsal/ventral pattern formation; embryonic digit morphogenesis; endocytosis; hair follicle development; integral to membrane; kidney development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of ossification; odontogenesis of dentin-containing tooth; plasma membrane; proximal/distal pattern formation; receptor clustering; regulation of protein phosphorylation; synaptic growth at neuromuscular junction IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) Lrp4 Megf7 Rattus norvegicus (Rat) TR4815_c0_g1_i1 O08873 MADD_RAT 2.00E-64 GO:0017112; GO:0000187; GO:0005737; GO:0097194; GO:0016021; GO:0005886; GO:0051726; GO:1902041 Rab guanyl-nucleotide exchange factor activity; activation of MAPK activity; cytoplasm; execution phase of apoptosis; integral to membrane; plasma membrane; regulation of cell cycle; regulation of extrinsic apoptotic signaling pathway via death domain receptors IPR005112; IPR001194; IPR005113; MAP kinase-activating death domain protein (Rab3 GDP/GTP exchange factor) Madd Rattus norvegicus (Rat) TR4850_c0_g1_i1 Q12955 ANK3_HUMAN 1.00E-08 GO:0043001; GO:0030315; GO:0007411; GO:0043194; GO:0007409; GO:0016323; GO:0045296; GO:0009986; GO:0043034; GO:0014704; GO:0044325; GO:0016328; GO:0005764; GO:0072660; GO:0071709; GO:0000281; GO:0033268; GO:0033270; GO:0010628; GO:1900827; GO:0045838; GO:2000651; GO:0010765; GO:0045211; GO:0030674; GO:0072661; GO:0019228; GO:0043266; GO:0007165; GO:0030507; GO:0014731; GO:0005200; GO:0050808 "Golgi to plasma membrane protein transport; T-tubule; axon guidance; axon initial segment; axonogenesis; basolateral plasma membrane; cadherin binding; cell surface; costamere; intercalated disc; ion channel binding; lateral plasma membrane; lysosome; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; node of Ranvier; paranode region of axon; positive regulation of gene expression; positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; postsynaptic membrane; protein binding, bridging; protein targeting to plasma membrane; regulation of action potential in neuron; regulation of potassium ion transport; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton; synapse organization" IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) TR4857_c0_g1_i1 O35385 PPE2_MOUSE 2.00E-30 GO:0005509; GO:0050906; GO:0005506; GO:0030145; GO:0043409; GO:0010801; GO:0004722; GO:0007601 calcium ion binding; detection of stimulus involved in sensory perception; iron ion binding; manganese ion binding; negative regulation of MAPK cascade; negative regulation of peptidyl-threonine phosphorylation; protein serine/threonine phosphatase activity; visual perception IPR011992; IPR018247; IPR002048; IPR000048; IPR004843; IPR013235; IPR012008; IPR006186; Serine/threonine-protein phosphatase with EF-hands 2 (PPEF-2) (EC 3.1.3.16) Ppef2 Mus musculus (Mouse) TR4858_c0_g1_i1 Q8K0U4 HS12A_MOUSE 1.00E-09 GO:0005524 ATP binding Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) TR4872_c1_g1_i1 P82596 PLC_HALLA 8.00E-09 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR4876_c0_g1_i1 Q9BX70 BTBD2_HUMAN 9.00E-16 GO:0000932 Q7L5N1; P04637 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) TR4876_c0_g2_i1 Q9BX70 BTBD2_HUMAN 9.00E-16 GO:0000932 Q7L5N1; P04637 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) TR4880_c0_g1_i1 O43301 HS12A_HUMAN 1.00E-18 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR4883_c0_g1_i1 Q3V0J4 ANR53_MOUSE 2.00E-07 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 53 Ankrd53 Mus musculus (Mouse) TR4883_c1_g1_i1 P23631 LATA_LATTR 4.00E-07 GO:0006887; GO:0016021; GO:0072556 exocytosis; integral to membrane; other organism presynaptic membrane IPR002110; IPR020683; IPR028047; Alpha-latrotoxin-Lt1a (Alpha-LTX-Lt1a) (Alpha-latrotoxin) (Alpha-LTX) Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus) TR4887_c0_g1_i1 Q2EMV9 PAR14_MOUSE 4.00E-09 GO:0003950; GO:0005737; GO:0003676; GO:0005634; GO:0005886; GO:0006355; GO:0006351 P06745 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleic acid binding; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR000504; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) TR4891_c0_g1_i1 A6NK53 ZN233_HUMAN 1.00E-21 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 233 ZNF233 Homo sapiens (Human) TR4897_c0_g1_i1 Q502W6 VWA3B_HUMAN 7.00E-24 IPR002035; von Willebrand factor A domain-containing protein 3B VWA3B Homo sapiens (Human) TR4903_c0_g1_i1 Q3T930 EST5A_SHEEP 7.00E-10 GO:0004091; GO:0005576 carboxylesterase activity; extracellular region IPR002018; IPR019826; IPR019819; Carboxylesterase 5A (EC 3.1.1.1) (Carboxylesterase-like urinary excreted protein homolog) (Cauxin) (Fragment) CES5A CES7 Ovis aries (Sheep) TR4903_c0_g2_i1 Q04791 SASB_ANAPL 1.00E-20 GO:0006633; GO:0016787 fatty acid biosynthetic process; hydrolase activity IPR002018; IPR019826; IPR019819; "Fatty acyl-CoA hydrolase precursor, medium chain (EC 3.1.2.-) (Thioesterase B)" Anas platyrhynchos (Domestic duck) (Anas boschas) TR4916_c0_g1_i1 Q96RW7 HMCN1_HUMAN 2.00E-11 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR4917_c0_g1_i1 B4NKL0 TMEDE_DROWI 4.00E-45 GO:0009953; GO:0005789; GO:0016021; GO:0006810 dorsal/ventral pattern formation; endoplasmic reticulum membrane; integral to membrane; transport IPR009038; Transmembrane emp24 domain-containing protein eca eca GK12749 Drosophila willistoni (Fruit fly) TR4918_c0_g1_i1 Q19791 GON1_CAEEL 2.00E-12 GO:0006888; GO:0005604; GO:0005623; GO:0016477; GO:0008406; GO:0004222; GO:0008237; GO:0006508; GO:0008270 ER to Golgi vesicle-mediated transport; basement membrane; cell; cell migration; gonad development; metalloendopeptidase activity; metallopeptidase activity; proteolysis; zinc ion binding IPR010294; IPR024079; IPR012314; IPR001590; IPR013273; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs gon-1 (ADAMTS gon-1) (EC 3.4.24.-) (Abnormal gonad development protein 1) gon-1 F25H8.3 Caenorhabditis elegans TR4920_c1_g1_i1 Q99NH7 S26A5_MOUSE 3.00E-09 GO:0016323; GO:0016021; GO:0016328; GO:0008360; GO:0042391; GO:0008271; GO:0007605; GO:0030507; GO:0008272 basolateral plasma membrane; integral to membrane; lateral plasma membrane; regulation of cell shape; regulation of membrane potential; secondary active sulfate transmembrane transporter activity; sensory perception of sound; spectrin binding; sulfate transport IPR018045; IPR002645; IPR001902; IPR011547; Prestin (Solute carrier family 26 member 5) Slc26a5 Pres Mus musculus (Mouse) TR4925_c0_g1_i1 B8MYV0 XYND_ASPFN 3.00E-06 GO:0006879; GO:0005576; GO:0008199; GO:0006826; GO:0009044; GO:0045493 "cellular iron ion homeostasis; extracellular region; ferric iron binding; iron ion transport; xylan 1,4-beta-xylosidase activity; xylan catabolic process" IPR002024; IPR026891; IPR026892; IPR002772; IPR001764; IPR017853; Glycan degradation; xylan degradation. "Probable exo-1,4-beta-xylosidase xlnD (EC 3.2.1.37) (1,4-beta-D-xylan xylohydrolase xlnD) (Beta-xylosidase A) (Beta-xylosidase xlnD) (Xylobiase xlnD)" xlnD xylA AFLA_082390 Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167) TR494_c1_g1_i1 A3KMV5 UBA1_BOVIN 4.00E-55 GO:0005524; GO:0016874; GO:0016567; GO:0008641 ATP binding; ligase activity; protein ubiquitination; small protein activating enzyme activity IPR009036; IPR016040; IPR000594; IPR018965; IPR023280; IPR000127; IPR019572; IPR018075; IPR018074; IPR000011; Protein modification; protein ubiquitination. Ubiquitin-like modifier-activating enzyme 1 (Ubiquitin-activating enzyme E1) UBA1 UBE1 Bos taurus (Bovine) TR4942_c0_g1_i1 O48646 GPX6_ARATH 7.00E-12 GO:0048046; GO:0009507; GO:0005829; GO:0004602; GO:0005739; GO:0047066; GO:0005886; GO:0046686; GO:0006979; GO:0009651 apoplast; chloroplast; cytosol; glutathione peroxidase activity; mitochondrion; phospholipid-hydroperoxide glutathione peroxidase activity; plasma membrane; response to cadmium ion; response to oxidative stress; response to salt stress IPR000889; IPR012336; "Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial (AtGPX1) (PHGPx) (EC 1.11.1.12)" GPX6 GPX1 At4g11600 T5C23.30 Arabidopsis thaliana (Mouse-ear cress) TR4943_c0_g1_i1 Q3UMR0 ANR27_MOUSE 7.00E-09 GO:0005096; GO:0005769; GO:0045022; GO:0005085; GO:0005764; GO:0043547 Q8QZZ8 GTPase activator activity; early endosome; early endosome to late endosome transport; guanyl-nucleotide exchange factor activity; lysosome; positive regulation of GTPase activity IPR002110; IPR020683; IPR003123; IPR013995; Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein) (VPS9-ankyrin-repeat protein) Ankrd27 Varp Mus musculus (Mouse) TR4949_c0_g1_i1 Q8BZE1 DMBTL_MOUSE 1.00E-22 GO:0005576; GO:0016020; GO:0005044 extracellular region; membrane; scavenger receptor activity IPR000859; IPR001190; IPR017448; Putative DMBT1-like protein Mus musculus (Mouse) TR495_c0_g1_i1 Q3UHD1 BAI1_MOUSE 2.00E-13 GO:0004930; GO:0016021; GO:0016525; GO:0007218; GO:0005886 G-protein coupled receptor activity; integral to membrane; negative regulation of angiogenesis; neuropeptide signaling pathway; plasma membrane IPR022624; IPR017981; IPR008077; IPR001879; IPR000832; IPR000203; IPR000884; Brain-specific angiogenesis inhibitor 1 Bai1 Mus musculus (Mouse) TR4962_c1_g1_i1 Q61609 S20A1_MOUSE 9.00E-06 GO:0005316; GO:0005315; GO:0016021; GO:0005886; GO:0043123; GO:0004871 high affinity inorganic phosphate:sodium symporter activity; inorganic phosphate transmembrane transporter activity; integral to membrane; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity IPR001204; Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) Slc20a1 Glvr1 Pit1 Mus musculus (Mouse) TR4967_c1_g1_i1 P33527 MRP1_HUMAN 1.00E-33 GO:0005524; GO:0042626; GO:0005794; GO:0019369; GO:0009235; GO:0005887; GO:0006691; GO:0005634; GO:0042493 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; Golgi apparatus; arachidonic acid metabolic process; cobalamin metabolic process; integral to plasma membrane; leukotriene metabolic process; nucleus; response to drug" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP MRP1 Homo sapiens (Human) TR4969_c0_g1_i1 Q5UPG5 YL093_MIMIV 5.00E-17 IPR002110; IPR020683; Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) TR4971_c0_g1_i1 Q9VAC5 ADA17_DROME 1.00E-25 GO:0016021; GO:0006509; GO:0004222; GO:0008270 integral to membrane; membrane protein ectodomain proteolysis; metalloendopeptidase activity; zinc ion binding IPR001762; IPR024079; IPR001590; IPR002870; ADAM 17-like protease (EC 3.4.24.-) Tace CG7908 Drosophila melanogaster (Fruit fly) TR4977_c0_g1_i1 Q962S4 RL39_SPOFR 1.00E-23 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000077; IPR020083; IPR023626; 60S ribosomal protein L39 RpL39 Spodoptera frugiperda (Fall armyworm) TR4994_c0_g1_i1 P67985 RL22_PIG 2.00E-23 GO:0003723; GO:0046632; GO:0022625; GO:0008201; GO:0003735; GO:0006412 RNA binding; alpha-beta T cell differentiation; cytosolic large ribosomal subunit; heparin binding; structural constituent of ribosome; translation IPR002671; 60S ribosomal protein L22 (Heparin-binding protein HBp15) RPL22 Sus scrofa (Pig) TR50_c0_g1_i1 Q03348 PTPRA_RAT 1.00E-19 GO:0016021; GO:0043231; GO:0048709; GO:0005886; GO:0048714; GO:0032403; GO:0004725 P28648 integral to membrane; intracellular membrane-bounded organelle; oligodendrocyte differentiation; plasma membrane; positive regulation of oligodendrocyte differentiation; protein complex binding; protein tyrosine phosphatase activity IPR000387; IPR016130; IPR000242; IPR016336; IPR027262; Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) Ptpra Lrp Rattus norvegicus (Rat) TR5004_c0_g2_i1 E1BD59 TRI56_BOVIN 1.00E-07 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) TR5008_c0_g1_i1 Q9NZJ4 SACS_HUMAN 7.00E-09 GO:0005524; GO:0030424; GO:0070852; GO:0008219; GO:0051087; GO:0030425; GO:0005739; GO:0090084; GO:0005634; GO:0006457 ATP binding; axon; cell body fiber; cell death; chaperone binding; dendrite; mitochondrion; negative regulation of inclusion body assembly; nucleus; protein folding IPR001623; IPR003594; IPR007842; IPR000626; Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) TR5017_c1_g1_i1 Q8N539 FBCD1_HUMAN 3.00E-35 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 UNQ701/PRO1346 Homo sapiens (Human) TR5022_c0_g1_i1 P79222 CALCR_RABIT 2.00E-56 GO:0007202; GO:0032841; GO:0004948; GO:0016021; GO:0005886; GO:0045762 activation of phospholipase C activity; calcitonin binding; calcitonin receptor activity; integral to membrane; plasma membrane; positive regulation of adenylate cyclase activity IPR003287; IPR017981; IPR001688; IPR001879; IPR000832; IPR017983; Calcitonin receptor (CT-R) CALCR Oryctolagus cuniculus (Rabbit) TR5023_c0_g1_i1 P41938 HCDH2_CAEEL 2.00E-34 GO:0003857; GO:0070403; GO:0006635; GO:0005759 3-hydroxyacyl-CoA dehydrogenase activity; NAD+ binding; fatty acid beta-oxidation; mitochondrial matrix IPR022694; IPR006180; IPR006176; IPR006108; IPR008927; IPR013328; IPR016040; Lipid metabolism; fatty acid beta-oxidation. Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3 (EC 1.1.1.35) B0272.3 Caenorhabditis elegans TR5039_c1_g1_i1 Q16581 C3AR_HUMAN 3.00E-08 GO:0004943; GO:0004982; GO:0008015; GO:0006935; GO:0004876; GO:0007204; GO:0006954; GO:0005887; GO:0004435; GO:0045766; GO:0010759; GO:0090023; GO:0010575 C3a anaphylatoxin receptor activity; N-formyl peptide receptor activity; blood circulation; chemotaxis; complement component C3a receptor activity; elevation of cytosolic calcium ion concentration; inflammatory response; integral to plasma membrane; phosphatidylinositol phospholipase C activity; positive regulation of angiogenesis; positive regulation of macrophage chemotaxis; positive regulation of neutrophil chemotaxis; positive regulation vascular endothelial growth factor production IPR001644; IPR002234; IPR000826; IPR000276; IPR017452; C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R) C3AR1 AZ3B C3R1 HNFAG09 Homo sapiens (Human) TR5039_c1_g2_i1 Q9VNM1 NPFR1_DROME 7.00E-50 GO:0005887; GO:0030536; GO:0007194; GO:0042263; GO:0004983; GO:0006950; GO:0004995 integral to plasma membrane; larval feeding behavior; negative regulation of adenylate cyclase activity; neuropeptide F receptor activity; neuropeptide Y receptor activity; response to stress; tachykinin receptor activity IPR000276; IPR017452; IPR000611; Neuropeptide F receptor (DmNPFR1) NPFR1 CG1147 Drosophila melanogaster (Fruit fly) TR5052_c0_g1_i1 Q9Y490 TLN1_HUMAN 9.00E-21 GO:0015629; GO:0006987; GO:0007411; GO:0007155; GO:0009986; GO:0005911; GO:0007043; GO:0007044; GO:0044267; GO:0005813; GO:0030866; GO:0007016; GO:0005829; GO:0070062; GO:0005925; GO:0043231; GO:0006936; GO:0005886; GO:0030168; GO:0002576; GO:0001726; GO:0032587; GO:0005200 P00533; P04626; P05556; P05106 actin cytoskeleton; activation of signaling protein activity involved in unfolded protein response; axon guidance; cell adhesion; cell surface; cell-cell junction; cell-cell junction assembly; cell-substrate junction assembly; cellular protein metabolic process; centrosome; cortical actin cytoskeleton organization; cytoskeletal anchoring at plasma membrane; cytosol; extracellular vesicular exosome; focal adhesion; intracellular membrane-bounded organelle; muscle contraction; plasma membrane; platelet activation; platelet degranulation; ruffle; ruffle membrane; structural constituent of cytoskeleton IPR019749; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR002558; IPR002404; IPR011993; IPR015710; IPR015224; IPR015009; IPR006077; Talin-1 TLN1 KIAA1027 TLN Homo sapiens (Human) TR5053_c0_g1_i1 P14198 AAC4_DICDI 4.00E-12 GO:0016021 integral to membrane AAC-rich mRNA clone AAC4 protein AAC4 DDB_G0267458 Dictyostelium discoideum (Slime mold) TR5061_c0_g1_i1 Q9WTR2 M3K6_MOUSE 4.00E-21 GO:0005524; GO:0004709; GO:0000165; GO:0000287 Q99683 ATP binding; MAP kinase kinase kinase activity; MAPK cascade; magnesium ion binding IPR025136; IPR011009; IPR000719; IPR017441; IPR013761; IPR002290; IPR008271; Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) Map3k6 Ask2 Mapkkk6 Mekk6 Mus musculus (Mouse) TR5064_c0_g2_i1 P24044 CALM_PLAFA 3.00E-31 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) Plasmodium falciparum TR5066_c0_g1_i1 Q562E7 WDR81_HUMAN 1.00E-13 GO:0010923; GO:0016772 "negative regulation of phosphatase activity; transferase activity, transferring phosphorus-containing groups" IPR000409; IPR011009; IPR015943; IPR001680; IPR017986; WD repeat-containing protein 81 WDR81 Homo sapiens (Human) TR5105_c0_g1_i1 P49263 PXN1_XENLA 5.00E-06 GO:0007155; GO:0046872 cell adhesion; metal ion binding IPR000421; IPR008985; IPR013320; IPR006585; IPR008979; IPR001759; Pentraxin fusion protein pxn1 Xenopus laevis (African clawed frog) TR5111_c0_g1_i1 Q4R6F2 CF070_MACFA 9.00E-21 GO:0016021 integral to membrane IPR025209; ER membrane-associated RNA degradation protein (Fragment) ERMARD QtsA-18153 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR5121_c0_g1_i1 A6BM72 MEG11_HUMAN 1.00E-14 GO:0016323; GO:0034109; GO:0016021; GO:0010842 basolateral plasma membrane; homotypic cell-cell adhesion; integral to membrane; retina layer formation IPR000742; IPR013032; IPR002049; IPR011489; Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) TR5132_c0_g1_i1 Q9ES45 DUOX2_RAT 1.00E-32 GO:0016174; GO:0016324; GO:0005509; GO:0042335; GO:0019221; GO:0020037; GO:0042446; GO:0042744; GO:0016021; GO:0004601; GO:0051591; GO:0006590 NAD(P)H oxidase activity; apical plasma membrane; calcium ion binding; cuticle development; cytokine-mediated signaling pathway; heme binding; hormone biosynthetic process; hydrogen peroxide catabolic process; integral to membrane; peroxidase activity; response to cAMP; thyroid hormone generation IPR011992; IPR018247; IPR002048; IPR013112; IPR017927; IPR013130; IPR013121; IPR010255; IPR002007; IPR019791; IPR017938; Hormone biosynthesis; thyroid hormone biosynthesis. Dual oxidase 2 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 2) (Long NOX 2) (NADH/NADPH thyroid oxidase THOX2) (Thyroid oxidase 2) Duox2 Lnox2 Thox2 Rattus norvegicus (Rat) TR5136_c0_g2_i1 P58308 OX2R_MOUSE 2.00E-09 GO:0022410; GO:0007631; GO:0016021; GO:0007218; GO:0016499; GO:0017046; GO:0007200; GO:0005886 circadian sleep/wake cycle process; feeding behavior; integral to membrane; neuropeptide signaling pathway; orexin receptor activity; peptide hormone binding; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane IPR000276; IPR017452; IPR000204; IPR004060; Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Mox2r Mus musculus (Mouse) TR5179_c0_g1_i1 Q6IRM9 ZWILC_XENLA 3.00E-22 GO:0051301; GO:0000777; GO:0007067; GO:0007093 cell division; condensed chromosome kinetochore; mitosis; mitotic cell cycle checkpoint IPR018630; Protein zwilch homolog zwilch Xenopus laevis (African clawed frog) TR5183_c0_g1_i1 Q9JJ66 CDC20_MOUSE 4.00E-13 GO:0051488; GO:0005680; GO:0031145; GO:0030154; GO:0051301; GO:0005737; GO:0005815; GO:0007067; GO:0007399; GO:0090129; GO:0031915; GO:0016567; GO:0040020; GO:0000922 Q8CDI2; Q8VDQ8 activation of anaphase-promoting complex activity; anaphase-promoting complex; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell differentiation; cell division; cytoplasm; microtubule organizing center; mitosis; nervous system development; positive regulation of synapse maturation; positive regulation of synaptic plasticity; protein ubiquitination; regulation of meiosis; spindle pole IPR015943; IPR001680; IPR019775; IPR017986; Protein modification; protein ubiquitination. Cell division cycle protein 20 homolog (mmCdc20) (p55CDC) Cdc20 Mus musculus (Mouse) TR5196_c0_g1_i1 Q6DIR8 PALD_XENTR 7.00E-36 GO:0005829 cytosol Paladin pald1 pald TGas002h03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR5213_c0_g1_i1 Q05423 FABP7_CHICK 5.00E-11 GO:0042995; GO:0021846; GO:0005737; GO:0008289; GO:0022008; GO:0043025; GO:0060134; GO:0005215 cell projection; cell proliferation in forebrain; cytoplasm; lipid binding; neurogenesis; neuronal cell body; prepulse inhibition; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; "Fatty acid-binding protein, brain (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7) (Fatty acid-binding protein, retina) (R-FABP)" FABP7 Gallus gallus (Chicken) TR5213_c1_g1_i1 P40220 RABP1_CHICK 2.00E-08 GO:0005737; GO:0016918; GO:0019841; GO:0005215 cytoplasm; retinal binding; retinol binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; Cellular retinoic acid-binding protein 1 (Cellular retinoic acid-binding protein I) (CRABP-I) CRABP1 Gallus gallus (Chicken) TR5214_c0_g1_i1 Q1L9A2 OPA3_DANRE 2.00E-13 GO:0007626; GO:0005739; GO:0050881; GO:0031413 locomotory behavior; mitochondrion; musculoskeletal movement; regulation of buoyancy IPR010754; Optic atrophy 3 protein homolog opa3 si:dkey-12o15.3 Danio rerio (Zebrafish) (Brachydanio rerio) TR5234_c1_g1_i1 Q7ZVP1 JADE3_DANRE 1.00E-10 GO:0008270 zinc ion binding IPR019542; IPR019786; IPR011011; IPR001965; IPR019787; IPR013083; Protein Jade-3 (PHD finger protein 16) phf16 jade3 Danio rerio (Zebrafish) (Brachydanio rerio) TR5239_c1_g1_i1 Q76LT8 UBP48_RAT 9.00E-06 GO:0008234; GO:0005737; GO:0045121; GO:0005634; GO:0045211; GO:0004221; GO:0006511 cysteine-type peptidase activity; cytoplasm; membrane raft; nucleus; postsynaptic membrane; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR006615; IPR018200; IPR001394; IPR000626; Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) (Deubiquitinating enzyme 48) (Synaptic ubiquitin-specific protease) (synUSP) (Ubiquitin thioesterase 48) (Ubiquitin-specific-processing protease 48) Usp48 Rattus norvegicus (Rat) TR5243_c0_g1_i1 P54212 CAH_DUNSA 4.00E-09 GO:0004089; GO:0006730; GO:0006950; GO:0008270 carbonate dehydratase activity; one-carbon metabolic process; response to stress; zinc ion binding IPR001148; IPR023561; IPR018338; Carbonic anhydrase (EC 4.2.1.1) (Carbonate dehydratase) DCA Dunaliella salina (Green alga) TR5243_c0_g2_i1 P43166 CAH7_HUMAN 9.00E-18 GO:0015701; GO:0004089; GO:0005829; GO:0006730; GO:0044281; GO:0008270 bicarbonate transport; carbonate dehydratase activity; cytosol; one-carbon metabolic process; small molecule metabolic process; zinc ion binding IPR001148; IPR023561; IPR018338; IPR018438; Carbonic anhydrase 7 (EC 4.2.1.1) (Carbonate dehydratase VII) (Carbonic anhydrase VII) (CA-VII) CA7 Homo sapiens (Human) TR5249_c0_g1_i1 Q0KIA2 Y9801_DROME 1.00E-09 GO:0003824; GO:0008152 catalytic activity; metabolic process IPR001932; PP2C-like domain-containing protein CG9801 CG9801 Drosophila melanogaster (Fruit fly) TR5261_c0_g1_i1 O95954 FTCD_HUMAN 7.00E-62 GO:0005794; GO:0005814; GO:0007010; GO:0005829; GO:0005542; GO:0006760; GO:0030412; GO:0030409; GO:0006548; GO:0019556; GO:0019557; GO:0035999 Golgi apparatus; centriole; cytoskeleton organization; cytosol; folic acid binding; folic acid-containing compound metabolic process; formimidoyltetrahydrofolate cyclodeaminase activity; glutamate formimidoyltransferase activity; histidine catabolic process; histidine catabolic process to glutamate and formamide; histidine catabolic process to glutamate and formate; tetrahydrofolate interconversion IPR007044; IPR013802; IPR004227; IPR012886; IPR022384; Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1. One-carbon metabolism; tetrahydrofolate interconversion. Formimidoyltransferase-cyclodeaminase (Formiminotransferase-cyclodeaminase) (FTCD) (LCHC1) [Includes: Glutamate formimidoyltransferase (EC 2.1.2.5) (Glutamate formiminotransferase) (Glutamate formyltransferase); Formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) (Formiminotetrahydrofolate cyclodeaminase)] FTCD Homo sapiens (Human) TR5264_c1_g1_i1 Q24432 OMB_DROME 3.00E-20 GO:0003677; GO:0001745; GO:0048066; GO:0007476; GO:0000122; GO:0005634; GO:0035265; GO:0003700; GO:0006351; GO:0048100 "DNA binding; compound eye morphogenesis; developmental pigmentation; imaginal disc-derived wing morphogenesis; negative regulation of transcription from RNA polymerase II promoter; nucleus; organ growth; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; wing disc anterior/posterior pattern formation" IPR021101; IPR008967; IPR001699; IPR018186; Optomotor-blind protein (Lethal(1)optomotor-blind) (L(1)omb) (Protein bifid) bi OMB CG3578 Drosophila melanogaster (Fruit fly) TR5271_c0_g4_i1 Q962S4 RL39_SPOFR 2.00E-22 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000077; IPR020083; IPR023626; 60S ribosomal protein L39 RpL39 Spodoptera frugiperda (Fall armyworm) TR5277_c0_g1_i1 O75382 TRIM3_HUMAN 3.00E-07 GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0015031; GO:0008270 cytoplasm; early endosome; nervous system development; protein C-terminus binding; protein transport; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) TR5281_c0_g1_i1 A2RRH5 WDR27_HUMAN 2.00E-10 IPR011047; IPR015943; IPR001680; IPR017986; WD repeat-containing protein 27 WDR27 Homo sapiens (Human) TR5296_c0_g1_i1 Q6P6T4 EMAL2_RAT 4.00E-07 GO:0003824; GO:0005737; GO:0008152; GO:0005874; GO:0008022; GO:0005102 catalytic activity; cytoplasm; metabolic process; microtubule; protein C-terminus binding; receptor binding IPR005108; IPR011047; IPR011041; IPR015943; IPR001680; IPR017986; Echinoderm microtubule-associated protein-like 2 (EMAP-2) Eml2 Emap2 Rattus norvegicus (Rat) TR5334_c0_g2_i1 Q96RV3 PCX1_HUMAN 7.00E-27 GO:0016021 integral to membrane IPR007735; Pecanex-like protein 1 (Pecanex homolog) PCNX KIAA0805 KIAA0995 PCNXL1 Homo sapiens (Human) TR5343_c1_g1_i1 Q503M4 MT12B_DANRE 7.00E-08 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 12-B (MCT 12-B) (Solute carrier family 16 member 12-B) slc16a12b slc16a12 zgc:110441 Danio rerio (Zebrafish) (Brachydanio rerio) TR5345_c0_g2_i1 P06787 CALM_YEAST 7.00E-14 GO:0006607; GO:0005509; GO:0048306; GO:0007114; GO:0005935; GO:0005934; GO:0005823; GO:0000131; GO:0000742; GO:0043332; GO:0016237; GO:0006661; GO:0006898; GO:0051300; GO:0042991; GO:0042144 P23287; Q04439; P32380 "NLS-bearing protein import into nucleus; calcium ion binding; calcium-dependent protein binding; cell budding; cellular bud neck; cellular bud tip; central plaque of spindle pole body; incipient cellular bud site; karyogamy involved in conjugation with cellular fusion; mating projection tip; microautophagy; phosphatidylinositol biosynthetic process; receptor-mediated endocytosis; spindle pole body organization; transcription factor import into nucleus; vacuole fusion, non-autophagic" IPR011992; IPR018247; IPR002048; Calmodulin (CaM) CMD1 YBR109C YBR0904 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR5355_c0_g1_i1 B0BLS0 OST4_RAT 4.00E-14 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR018943; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 Ost4 Rattus norvegicus (Rat) TR5373_c0_g1_i1 Q9R1R2 TRIM3_MOUSE 1.00E-07 GO:0005737; GO:0005769; GO:0015031; GO:0008270 cytoplasm; early endosome; protein transport; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) TR5377_c0_g1_i1 Q63537 SYN2_RAT 7.00E-28 GO:0005524; GO:0003824; GO:0030054; GO:0008092; GO:0008152; GO:0007269; GO:0046928; GO:0008021 ATP binding; catalytic activity; cell junction; cytoskeletal protein binding; metabolic process; neurotransmitter secretion; regulation of neurotransmitter secretion; synaptic vesicle IPR013815; IPR013816; IPR016185; IPR001359; IPR020898; IPR019735; IPR019736; IPR020897; Synapsin-2 (Synapsin II) Syn2 Rattus norvegicus (Rat) TR5389_c1_g1_i1 Q6FJN0 MBF1_CANGA 1.00E-15 GO:0006355; GO:0043565; GO:0006351 "regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription, DNA-dependent" IPR001387; IPR010982; IPR013729; Multiprotein-bridging factor 1 MBF1 CAGL0M04983g Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) TR5403_c1_g1_i1 P41696 AZF1_YEAST 4.00E-27 GO:0000978; GO:0001077; GO:0071322; GO:0005829; GO:0046872; GO:0005634; GO:0060237 RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; cellular response to carbohydrate stimulus; cytosol; metal ion binding; nucleus; regulation of fungal-type cell wall organization IPR007087; IPR015880; IPR013087; Asparagine-rich zinc finger protein AZF1 AZF1 YOR113W O3244 YOR3244W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR5403_c1_g1_i2 Q6BEB4 SP5_HUMAN 3.00E-16 GO:0060349; GO:0046872; GO:0005634; GO:0036342; GO:0006355; GO:0043565; GO:0006351 "bone morphogenesis; metal ion binding; nucleus; post-anal tail morphogenesis; regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Transcription factor Sp5 SP5 Homo sapiens (Human) TR5403_c1_g2_i1 G5EBU4 ZAG1_CAEEL 8.00E-20 GO:0007411; GO:0046872; GO:0000122; GO:0005634; GO:0045773; GO:0043565; GO:0003700; GO:0006351 "axon guidance; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of axon extension; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR017970; IPR001356; IPR009057; IPR007087; IPR015880; IPR013087; Zinc finger E-box-binding homeobox protein zag-1 (Zinc finger involved in axon guidance 1) (ZAG-1) zag-1 F28F9.1 Caenorhabditis elegans TR5403_c1_g3_i1 Q14590 ZN235_HUMAN 1.00E-68 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) TR5419_c1_g1_i1 P49259 PLA2R_BOVIN 3.00E-09 GO:0030246; GO:0009986; GO:0001816; GO:0005576; GO:0016021; GO:1900139; GO:1900138; GO:0090403; GO:0043274; GO:0005886; GO:0043517; GO:0090238; GO:0072593; GO:0004872; GO:0006898; GO:0090399 "carbohydrate binding; cell surface; cytokine production; extracellular region; integral to membrane; negative regulation of arachidonic acid secretion; negative regulation of phospholipase A2 activity; oxidative stress-induced premature senescence; phospholipase binding; plasma membrane; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of arachidonic acid secretion; reactive oxygen species metabolic process; receptor activity; receptor-mediated endocytosis; replicative senescence" IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR000772; Secretory phospholipase A2 receptor (PLA2-R) (PLA2R) (180 kDa secretory phospholipase A2 receptor) (M-type receptor) [Cleaved into: Soluble secretory phospholipase A2 receptor (Soluble PLA2-R) (Soluble PLA2R)] PLA2R1 Bos taurus (Bovine) TR5421_c0_g1_i1 Q96RW7 HMCN1_HUMAN 8.00E-17 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR5440_c1_g1_i1 A2A9C3 SZT2_MOUSE 2.00E-17 GO:0007417; GO:0005777; GO:0043473; GO:0009791 central nervous system development; peroxisome; pigmentation; post-embryonic development Protein SZT2 (Seizure threshold 2 protein) (Transcript increased in glutamate resistance) (TIGR) Szt2 Mus musculus (Mouse) TR5458_c0_g1_i1 P74148 Y1388_SYNY3 7.00E-12 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein Sll1388 (USP Sll1388) sll1388 Synechocystis sp. (strain PCC 6803 / Kazusa) TR5461_c0_g1_i1 Q6SP97 ENKUR_MOUSE 6.00E-21 GO:0005929 cilium IPR026150; IPR027012; Enkurin Enkur Mus musculus (Mouse) TR5463_c0_g2_i1 P27216 ANX13_HUMAN 6.00E-20 GO:0005509; GO:0005544; GO:0030154; GO:0005886 calcium ion binding; calcium-dependent phospholipid binding; cell differentiation; plasma membrane IPR001464; IPR018502; IPR018252; IPR009166; Annexin A13 (Annexin XIII) (Annexin-13) (Intestine-specific annexin) (ISA) ANXA13 ANX13 Homo sapiens (Human) TR5469_c0_g1_i1 Q5F4B8 S46A3_CHICK 2.00E-09 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR016196; Solute carrier family 46 member 3 SLC46A3 RCJMB04_1c21 Gallus gallus (Chicken) TR5476_c0_g1_i1 Q99MR1 PERQ1_MOUSE 1.00E-20 GO:0048009 insulin-like growth factor receptor signaling pathway IPR003169; PERQ amino acid-rich with GYF domain-containing protein 1 (GRB10-interacting GYF protein 1) Gigyf1 Kiaa4110 Perq1 Mus musculus (Mouse) TR5484_c0_g1_i1 Q9WVF7 DPOE1_MOUSE 2.00E-42 GO:0051539; GO:0003677; GO:0006260; GO:0000731; GO:0003887; GO:0000082; GO:0006287; GO:0003682; GO:0008622; GO:0000166; GO:0006297; GO:0008270 "4 iron, 4 sulfur cluster binding; DNA binding; DNA replication; DNA synthesis involved in DNA repair; DNA-directed DNA polymerase activity; G1/S transition of mitotic cell cycle; base-excision repair, gap-filling; chromatin binding; epsilon DNA polymerase complex; nucleotide binding; nucleotide-excision repair, DNA gap filling; zinc ion binding" IPR006172; IPR006133; IPR006134; IPR013697; IPR012337; DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A) Pole Pole1 Mus musculus (Mouse) TR5486_c0_g1_i1 Q8PDM9 NPD_XANCP 4.00E-18 GO:0070403; GO:0034979; GO:0005737; GO:0008270 NAD+ binding; NAD-dependent protein deacetylase activity; cytoplasm; zinc ion binding IPR003000; IPR026591; IPR026587; IPR026590; NAD-dependent protein deacetylase (EC 3.5.1.-) (Regulatory protein SIR2 homolog) cobB XCC0306 Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568) TR5486_c1_g2_i1 Q8R216 SIR4_MOUSE 1.00E-22 GO:0003950; GO:0070403; GO:0034979; GO:0006541; GO:0046872; GO:0005759; GO:0046322; GO:0046676; GO:0034983; GO:0046889; GO:0006471; GO:0006974; GO:0072350 NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent protein deacetylase activity; glutamine metabolic process; metal ion binding; mitochondrial matrix; negative regulation of fatty acid oxidation; negative regulation of insulin secretion; peptidyl-lysine deacetylation; positive regulation of lipid biosynthetic process; protein ADP-ribosylation; response to DNA damage stimulus; tricarboxylic acid metabolic process IPR003000; IPR026591; IPR026587; IPR026590; NAD-dependent protein deacetylase sirtuin-4 (EC 3.5.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4) Sirt4 Sir2l4 Mus musculus (Mouse) TR5490_c0_g1_i1 Q96MB7 HARB1_HUMAN 4.00E-12 GO:0005813; GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 centrosome; cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) HARBI1 C11orf77 Homo sapiens (Human) TR551_c0_g1_i1 Q9IAM1 XA1_DEIAC 6.00E-08 GO:0030246; GO:0005576; GO:0046872 carbohydrate binding; extracellular region; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; Snaclec agkisacutacin subunit A (Agk-A) Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus) TR5510_c1_g1_i1 Q55E72 PKS1_DICDI 3.00E-29 GO:0009813; GO:0005622; GO:0016210; GO:0016491; GO:0030639; GO:0019505 flavonoid biosynthetic process; intracellular; naringenin-chalcone synthase activity; oxidoreductase activity; polyketide biosynthetic process; resorcinol metabolic process IPR001227; IPR009081; IPR014043; IPR016035; IPR013154; IPR012328; IPR001099; IPR011032; IPR018201; IPR014031; IPR014030; IPR016036; IPR013217; IPR016040; IPR020801; IPR020841; IPR020843; IPR013968; IPR016039; IPR016038; Secondary metabolite biosynthesis; flavonoid biosynthesis. Probable polyketide synthase 1 (dipks1) [Includes: Polyketide synthase stlA (EC 2.3.1.-); Chalcone synthase stlA (EC 2.3.1.74) (Steely1)] stlA pks1 DDB_G0269364 Dictyostelium discoideum (Slime mold) TR5526_c0_g1_i1 Q99PF4 CAD23_MOUSE 5.00E-13 GO:0060088; GO:0005509; GO:0016339; GO:0005929; GO:0007156; GO:0016021; GO:0007626; GO:0005932; GO:0001917; GO:0005886; GO:0048563; GO:0050953; GO:0007605; GO:0032420; GO:0032426; GO:0045202 Q9ES64-3 auditory receptor cell stereocilium organization; calcium ion binding; calcium-dependent cell-cell adhesion; cilium; homophilic cell adhesion; integral to membrane; locomotory behavior; microtubule basal body; photoreceptor inner segment; plasma membrane; post-embryonic organ morphogenesis; sensory perception of light stimulus; sensory perception of sound; stereocilium; stereocilium bundle tip; synapse IPR002126; IPR015919; IPR020894; Cadherin-23 (Otocadherin) Cdh23 Mus musculus (Mouse) TR5532_c0_g1_i1 Q5SQE2 STB5L_DANRE 3.00E-63 GO:0005737; GO:0006887; GO:0016021; GO:0005886; GO:0015031 cytoplasm; exocytosis; integral to membrane; plasma membrane; protein transport IPR000664; IPR013577; IPR001388; IPR015943; IPR001680; IPR019775; IPR017986; Syntaxin-binding protein 5-like stxbp5l si:ch211-194d6.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR5532_c1_g1_i1 Q7SZE3 L2GL2_DANRE 5.00E-17 GO:0007049; GO:0005737; GO:0005856; GO:0007010; GO:0008544; GO:0006887; GO:0031581; GO:0030336; GO:0050680; GO:0010719; GO:0048919; GO:0045682 cell cycle; cytoplasm; cytoskeleton; cytoskeleton organization; epidermis development; exocytosis; hemidesmosome assembly; negative regulation of cell migration; negative regulation of epithelial cell proliferation; negative regulation of epithelial to mesenchymal transition; posterior lateral line neuromast development; regulation of epidermis development IPR000664; IPR013577; IPR015943; IPR001680; IPR019775; IPR017986; Lethal(2) giant larvae protein homolog 2 (Protein penner) llgl2 pen Danio rerio (Zebrafish) (Brachydanio rerio) TR5558_c1_g1_i1 Q8BFQ2 T229B_MOUSE 3.00E-30 GO:0016021 integral to membrane IPR010540; Transmembrane protein 229B TMEM229B Mus musculus (Mouse) TR5560_c0_g1_i1 Q2IA00 SPEF2_PIG 4.00E-27 GO:0005524; GO:0019205; GO:0006139 ATP binding; nucleobase-containing compound kinase activity; nucleobase-containing compound metabolic process IPR000850; IPR001715; IPR010441; IPR027417; Sperm flagellar protein 2 (Protein KPL2) SPEF2 KPL2 Sus scrofa (Pig) TR5570_c0_g1_i1 Q96MS0 ROBO3_HUMAN 6.00E-09 GO:0030424; GO:0016199; GO:0016021; GO:0001764 axon; axon midline choice point recognition; integral to membrane; neuron migration IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; Roundabout homolog 3 (Roundabout-like protein 3) ROBO3 Homo sapiens (Human) TR5570_c0_g2_i1 Q62407 SPEG_MOUSE 7.00E-08 GO:0005524; GO:0055013; GO:0001701; GO:0005634; GO:0004674; GO:0060541 ATP binding; cardiac muscle cell development; in utero embryonic development; nucleus; protein serine/threonine kinase activity; respiratory system development IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Striated muscle-specific serine/threonine-protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Speg Apeg1 Kiaa1297 Mus musculus (Mouse) TR5570_c0_g2_i2 Q8WZ42 TITIN_HUMAN 2.00E-10 GO:0005524; GO:0005794; GO:0031430; GO:0030018; GO:0051015; GO:0042805; GO:0007512; GO:0005509; GO:0005516; GO:0060048; GO:0048739; GO:0003300; GO:0055008; GO:0055003; GO:0000794; GO:0005829; GO:0035995; GO:0005576; GO:0043056; GO:0001701; GO:0007076; GO:0030049; GO:0018108; GO:0030168; GO:0002576; GO:0043621; GO:0004674; GO:0004713; GO:0045859; GO:0051592; GO:0045214; GO:0048769; GO:0030241; GO:0030240; GO:0005865; GO:0008307; GO:0097493; GO:0031433 Itself; P12814; P35609; P62158; P20807; O75953; O75923; P06733; Q14324; Q13203; P54296; P20929; Q5VST9; O75147; Q96CV9; O15273; Q969Q1 ATP binding; Golgi apparatus; M band; Z disc; actin filament binding; actinin binding; adult heart development; calcium ion binding; calmodulin binding; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle hypertrophy; cardiac muscle tissue morphogenesis; cardiac myofibril assembly; condensed nuclear chromosome; cytosol; detection of muscle stretch; extracellular region; forward locomotion; in utero embryonic development; mitotic chromosome condensation; muscle filament sliding; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; protein self-association; protein serine/threonine kinase activity; protein tyrosine kinase activity; regulation of protein kinase activity; response to calcium ion; sarcomere organization; sarcomerogenesis; skeletal muscle myosin thick filament assembly; skeletal muscle thin filament assembly; striated muscle thin filament; structural constituent of muscle; structural molecule activity conferring elasticity; telethonin binding IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR004168; IPR000719; IPR002290; IPR015129; IPR008266; Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) TR5574_c0_g1_i1 Q3U1D0 LINES_MOUSE 1.00E-06 IPR024875; Protein Lines homolog (Protein Lines homolog 2) (Wnt-signaling molecule Lines homolog 2) Lins Lins2 Wins2 Mus musculus (Mouse) TR5585_c1_g1_i1 Q07E02 CAV1_ORNAN 8.00E-14 GO:0000139; GO:0031295; GO:0005901; GO:0005768 Golgi membrane; T cell costimulation; caveola; endosome IPR001612; IPR015504; IPR018361; Caveolin-1 CAV1 Ornithorhynchus anatinus (Duckbill platypus) TR5587_c0_g1_i1 P38435 VKGC_HUMAN 6.00E-06 GO:0007596; GO:0005789; GO:0008488; GO:0016021; GO:0017187; GO:0043687 blood coagulation; endoplasmic reticulum membrane; gamma-glutamyl carboxylase activity; integral to membrane; peptidyl-glutamic acid carboxylation; post-translational protein modification IPR011020; IPR014710; IPR011051; IPR007782; Vitamin K-dependent gamma-carboxylase (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase) GGCX GC Homo sapiens (Human) TR5593_c0_g1_i1 Q8X187 CALM_PAXIN 9.00E-49 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) calA Paxillus involutus (Naked brimcap) TR5601_c0_g1_i1 Q86Z23 C1QL4_HUMAN 2.00E-09 GO:0005581 collagen IPR001073; IPR008983; Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) C1QL4 CTRP11 Homo sapiens (Human) TR5611_c0_g1_i1 A3KMI0 DHX29_XENLA 1.00E-15 GO:0005524; GO:0008026; GO:0016282; GO:0043024; GO:0003743 ATP binding; ATP-dependent helicase activity; eukaryotic 43S preinitiation complex; ribosomal small subunit binding; translation initiation factor activity IPR011545; IPR002464; IPR011709; IPR007502; IPR014001; IPR001650; IPR027417; ATP-dependent RNA helicase DHX29 (EC 3.6.4.13) (DEAH box protein 29) dhx29 Xenopus laevis (African clawed frog) TR5614_c0_g1_i1 Q95JN5 AT133_MACFA 4.00E-37 GO:0005524; GO:0006200; GO:0016887; GO:0006812; GO:0016021; GO:0046872 ATP binding; ATP catabolic process; ATPase activity; cation transport; integral to membrane; metal ion binding IPR004014; IPR006544; IPR008250; Probable cation-transporting ATPase 13A3 (EC 3.6.3.-) (ATPase family homolog up-regulated in senescence cells 1) (Fragment) ATP13A3 AFURS1 QtsA-14967 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR5618_c1_g1_i1 Q8VIK5 PEAR1_MOUSE 1.00E-15 GO:0016021; GO:0001891; GO:0043654 integral to membrane; phagocytic cup; recognition of apoptotic cell IPR000742; IPR013032; IPR002049; IPR011489; IPR009030; Platelet endothelial aggregation receptor 1 (mPEAR1) (Jagged and Delta protein) (Protein Jedi) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) Pear1 Jedi Megf12 Mus musculus (Mouse) TR563_c0_g1_i1 Q3T112 PSB8_BOVIN 3.00E-12 GO:0019882; GO:0005737; GO:0045444; GO:0005634; GO:0005839; GO:0051603; GO:1990111; GO:0004298 antigen processing and presentation; cytoplasm; fat cell differentiation; nucleus; proteasome core complex; proteolysis involved in cellular protein catabolic process; spermatoproteasome complex; threonine-type endopeptidase activity IPR000243; IPR016050; IPR001353; IPR023333; Proteasome subunit beta type-8 (EC 3.4.25.1) (Proteasome subunit beta-5i) PSMB8 Bos taurus (Bovine) TR5630_c0_g1_i1 P09478 ACH1_DROME 1.00E-06 GO:0004889; GO:0005892; GO:0030054; GO:0045211; GO:0017085; GO:0007271 "acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; postsynaptic membrane; response to insecticide; synaptic transmission, cholinergic" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit alpha-like 1 nAcRalpha-96Aa Acr96Aa AcrB als CG5610 Drosophila melanogaster (Fruit fly) TR5632_c0_g1_i1 Q5RFW0 SCAR5_DANRE 2.00E-07 GO:0006879; GO:0070287; GO:0005887; GO:0034755; GO:0070207; GO:0005044 cellular iron ion homeostasis; ferritin receptor activity; integral to plasma membrane; iron ion transmembrane transport; protein homotrimerization; scavenger receptor activity IPR008160; IPR001190; IPR017448; Scavenger receptor class A member 5 scara5 si:ch211-200p13.4 Danio rerio (Zebrafish) (Brachydanio rerio) TR5650_c2_g1_i1 E1BD59 TRI56_BOVIN 2.00E-06 GO:0005737; GO:0051607; GO:0032608; GO:0070534; GO:0034340; GO:0004842; GO:0008270 cytoplasm; defense response to virus; interferon-beta production; protein K63-linked ubiquitination; response to type I interferon; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) TR5652_c0_g1_i1 O93279 A4_TAKRU 3.00E-20 GO:0008201; GO:0016021; GO:0004867; GO:0046914 heparin binding; integral to membrane; serine-type endopeptidase inhibitor activity; transition metal ion binding IPR008155; IPR013803; IPR011178; IPR024329; IPR008154; IPR019744; IPR015849; IPR019745; IPR019543; IPR002223; IPR020901; Amyloid beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) [Cleaved into: Beta-amyloid protein (A-beta) (Beta-APP)] app Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) TR5668_c0_g1_i1 Q9URY6 DUR33_SCHPO 3.00E-08 GO:0005794; GO:0000139; GO:0016021; GO:0005886; GO:0015204 Golgi apparatus; Golgi membrane; integral to membrane; plasma membrane; urea transmembrane transporter activity IPR001734; IPR019900; Probable urea active transporter 3 dur3-3 SPAC869.03c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR567_c0_g1_i1 Q864Z3 S22A6_BOVIN 7.00E-06 GO:0015742; GO:0016323; GO:0005452; GO:0005887; GO:0008514; GO:0097254 alpha-ketoglutarate transport; basolateral plasma membrane; inorganic anion exchanger activity; integral to plasma membrane; organic anion transmembrane transporter activity; renal tubular secretion IPR020846; IPR016196; IPR004749; IPR005828; Solute carrier family 22 member 6 (Organic anion transporter 1) (Renal organic anion transporter 1) (ROAT1) SLC22A6 OAT1 Bos taurus (Bovine) TR5671_c0_g1_i1 Q8BX70 VP13C_MOUSE 1.00E-07 IPR015412; IPR026847; IPR026854; IPR009543; Vacuolar protein sorting-associated protein 13C Vps13c Kiaa3021 Mus musculus (Mouse) TR5673_c0_g1_i1 Q2T9X2 TCPD_BOVIN 1.00E-74 GO:0005524; GO:0042470; GO:0005815; GO:0006457 ATP binding; melanosome; microtubule organizing center; protein folding IPR012717; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) CCT4 Bos taurus (Bovine) TR5685_c0_g1_i1 Q8MQJ9 BRAT_DROME 1.00E-05 GO:0008356; GO:0055060; GO:0007411; GO:0007420; GO:0005737; GO:0007402; GO:0007406; GO:0048477; GO:0006909; GO:0009303; GO:0035282; GO:0030371; GO:0008270 asymmetric cell division; asymmetric neuroblast division resulting in ganglion mother cell formation; axon guidance; brain development; cytoplasm; ganglion mother cell fate determination; negative regulation of neuroblast proliferation; oogenesis; phagocytosis; rRNA transcription; segmentation; translation repressor activity; zinc ion binding IPR011042; IPR001258; IPR013017; IPR000315; Brain tumor protein brat CG10719 Drosophila melanogaster (Fruit fly) TR5686_c0_g2_i1 Q99N01 SO4A1_RAT 4.00E-19 GO:0016021; GO:0005886; GO:0042403; GO:0015349 integral to membrane; plasma membrane; thyroid hormone metabolic process; thyroid hormone transmembrane transporter activity IPR002350; IPR020846; IPR016196; IPR004156; Solute carrier organic anion transporter family member 4A1 (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) Slco4a1 Oatp4a1 Oatpe Slc21a12 Rattus norvegicus (Rat) TR5694_c0_g1_i1 Q14165 MLEC_HUMAN 2.00E-77 GO:0030246; GO:0005789; GO:0016021; GO:0043687; GO:0018279; GO:0006457 carbohydrate binding; endoplasmic reticulum membrane; integral to membrane; post-translational protein modification; protein N-linked glycosylation via asparagine; protein folding IPR021720; Malectin MLEC KIAA0152 Homo sapiens (Human) TR5699_c0_g1_i1 Q801G2 MPRAB_DANRE 2.00E-31 GO:0000187; GO:0016021; GO:0007275; GO:0007194; GO:0001556; GO:0005886; GO:0005496; GO:0003707 activation of MAPK activity; integral to membrane; multicellular organismal development; negative regulation of adenylate cyclase activity; oocyte maturation; plasma membrane; steroid binding; steroid hormone receptor activity IPR004254; "Membrane progestin receptor alpha-B (mPR alpha) (Progestin and adipoQ receptor family member VII, b)" paqr7b mpra paqr7 Danio rerio (Zebrafish) (Brachydanio rerio) TR5707_c0_g1_i1 Q5PQV5 TPBG_RAT 3.00E-06 GO:0005783; GO:0016021 endoplasmic reticulum; integral to membrane IPR000483; IPR001611; IPR003591; IPR000372; Trophoblast glycoprotein (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) Tpbg 5t4 Rattus norvegicus (Rat) TR5715_c0_g1_i1 Q5UPG5 YL093_MIMIV 1.00E-11 IPR002110; IPR020683; Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) TR5721_c0_g1_i1 Q5REG4 DTX3_PONAB 8.00E-21 GO:0007219; GO:0005737; GO:0016874; GO:0016567; GO:0008270 Notch signaling pathway; cytoplasm; ligase activity; protein ubiquitination; zinc ion binding IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase DTX3 (EC 6.3.2.-) (Protein deltex-3) (Deltex3) DTX3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR5723_c0_g1_i1 Q810A1 ZNF18_MOUSE 1.00E-13 GO:0003677; GO:0046872; GO:0005634; GO:0000981 DNA binding; metal ion binding; nucleus; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR027775; IPR001909; IPR008916; IPR003309; IPR027764; IPR007087; IPR015880; IPR013087; Zinc finger protein 18 (Zinc finger protein 535) (Zinc finger protein with KRAB and SCAN domains 6) Znf18 Zfp535 Zkscan6 Mus musculus (Mouse) TR5724_c0_g1_i1 Q9GZQ4 NMUR2_HUMAN 1.00E-35 GO:0005525; GO:0043006; GO:0050482; GO:0006816; GO:0007417; GO:0007204; GO:0007631; GO:0007625; GO:0048016; GO:0016021; GO:0005229; GO:0042924; GO:0001607; GO:0007200; GO:0005886; GO:0002023; GO:0006940; GO:0048265 GTP binding; activation of phospholipase A2 activity by calcium-mediated signaling; arachidonic acid secretion; calcium ion transport; central nervous system development; elevation of cytosolic calcium ion concentration; feeding behavior; grooming behavior; inositol phosphate-mediated signaling; integral to membrane; intracellular calcium activated chloride channel activity; neuromedin U binding; neuromedin U receptor activity; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; reduction of food intake in response to dietary excess; regulation of smooth muscle contraction; response to pain IPR000276; IPR017452; IPR005390; IPR005392; Neuromedin-U receptor 2 (NMU-R2) (G-protein coupled receptor FM-4) (G-protein coupled receptor TGR-1) NMUR2 NMU2R TGR1 Homo sapiens (Human) TR5740_c0_g1_i1 P56962 STX17_HUMAN 5.00E-20 GO:0030134; GO:0012507; GO:0006888; GO:0007030; GO:0005484; GO:0000149; GO:0031201; GO:0000046; GO:0000421; GO:0005829; GO:0005793; GO:0033116; GO:0097111; GO:0006887; GO:0016021; GO:0006886; GO:0005739; GO:0030868 ER to Golgi transport vesicle; ER to Golgi transport vesicle membrane; ER to Golgi vesicle-mediated transport; Golgi organization; SNAP receptor activity; SNARE binding; SNARE complex; autophagic vacuole fusion; autophagic vacuole membrane; cytosol; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; endoplasmic reticulum-Golgi intermediate compartment organization; exocytosis; integral to membrane; intracellular protein transport; mitochondrion; smooth endoplasmic reticulum membrane IPR006012; IPR010989; IPR000727; Syntaxin-17 STX17 Homo sapiens (Human) TR5743_c0_g1_i2 Q8VI56 LRP4_MOUSE 2.00E-06 GO:0016055; GO:0005509; GO:0030154; GO:0009953; GO:0042733; GO:0006897; GO:0001942; GO:0016021; GO:0001822; GO:0030178; GO:0090090; GO:0030279; GO:0042475; GO:0005886; GO:0042803; GO:0009954; GO:0043113; GO:0001932; GO:0051124 P25304; Q9ERE7 Wnt receptor signaling pathway; calcium ion binding; cell differentiation; dorsal/ventral pattern formation; embryonic digit morphogenesis; endocytosis; hair follicle development; integral to membrane; kidney development; negative regulation of Wnt receptor signaling pathway; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of ossification; odontogenesis of dentin-containing tooth; plasma membrane; protein homodimerization activity; proximal/distal pattern formation; receptor clustering; regulation of protein phosphorylation; synaptic growth at neuromuscular junction IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Low-density lipoprotein receptor-related protein 4 (LRP-4) (LDLR dan) Lrp4 Kiaa0816 Mus musculus (Mouse) TR5757_c1_g1_i1 P46023 GR101_LYMST 2.00E-07 GO:0016021; GO:0005886; GO:0016500 integral to membrane; plasma membrane; protein-hormone receptor activity IPR000276; IPR017452; IPR002131; IPR023415; IPR002172; IPR001611; IPR003591; IPR000372; G-protein coupled receptor GRL101 Lymnaea stagnalis (Great pond snail) TR5761_c0_g1_i1 Q07076 ANXA7_MOUSE 8.00E-29 GO:0005509; GO:0005544; GO:0008283; GO:0006874; GO:0009992; GO:0042584; GO:0005829; GO:0005789; GO:0007599; GO:0005635; GO:0005886; GO:0008360; GO:0009651; GO:0035176; GO:0031982 calcium ion binding; calcium-dependent phospholipid binding; cell proliferation; cellular calcium ion homeostasis; cellular water homeostasis; chromaffin granule membrane; cytosol; endoplasmic reticulum membrane; hemostasis; nuclear envelope; plasma membrane; regulation of cell shape; response to salt stress; social behavior; vesicle IPR001464; IPR018502; IPR018252; IPR013286; Annexin A7 (Annexin VII) (Annexin-7) (Synexin) Anxa7 Anx7 Mus musculus (Mouse) TR5762_c2_g1_i1 Q9D2J7 ANKR5_MOUSE 3.00E-09 GO:0005509 calcium ion binding IPR002110; IPR020683; IPR011992; Ankyrin repeat and EF-hand domain-containing protein 1 (Ankyrin repeat domain-containing protein 5) Ankef1 Ankrd5 Mus musculus (Mouse) TR5763_c0_g2_i1 Q9ET66 PI16_MOUSE 1.00E-12 GO:0005576; GO:0016021; GO:0030414 extracellular region; integral to membrane; peptidase inhibitor activity IPR001283; IPR018244; IPR014044; Peptidase inhibitor 16 (PI-16) (Cysteine-rich protease inhibitor) Pi16 Cripi Mus musculus (Mouse) TR5767_c0_g1_i1 P35072 TCB1_CAEBR 1.00E-11 GO:0003677; GO:0015074; GO:0005634; GO:0004803; GO:0006313 "DNA binding; DNA integration; nucleus; transposase activity; transposition, DNA-mediated" IPR002492; Transposable element Tcb1 transposase (Transposable element Barney transposase) Caenorhabditis briggsae TR5771_c0_g1_i1 P16273 PRPX_HORVU 2.00E-08 GO:0006952; GO:0009607 defense response; response to biotic stimulus Pathogen-related protein Hordeum vulgare (Barley) TR5774_c0_g1_i1 B4QU20 JUPIT_DROSI 1.00E-05 GO:0005829; GO:0005874; GO:0005875; GO:0008017; GO:0005634; GO:0031116; GO:0005819; GO:0005200 cytosol; microtubule; microtubule associated complex; microtubule binding; nucleus; positive regulation of microtubule polymerization; spindle; structural constituent of cytoskeleton Microtubule-associated protein Jupiter Jupiter GD20653 Drosophila simulans (Fruit fly) TR5777_c0_g1_i1 P86855 PWAPL_MYTGA 1.00E-28 GO:0005576; GO:0010466; GO:0030414 extracellular region; negative regulation of peptidase activity; peptidase inhibitor activity IPR008197; Perlwapin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR5782_c0_g1_i1 Q6PHS6 SNX13_MOUSE 4.00E-15 GO:0007154; GO:0031901; GO:0006886; GO:0035091; GO:0043547; GO:0038032 cell communication; early endosome membrane; intracellular protein transport; phosphatidylinositol binding; positive regulation of GTPase activity; termination of G-protein coupled receptor signaling pathway IPR001683; IPR003114; IPR013996; IPR016137; IPR000342; IPR013937; Sorting nexin-13 Snx13 Mus musculus (Mouse) TR5789_c0_g1_i1 Q1EHB3 ATS7_RAT 6.00E-09 GO:0004222; GO:0005578; GO:0006508; GO:0008270 metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR001590; IPR013273; IPR002870; IPR010909; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS 7) (ADAM-TS7) (ADAMTS-7) (EC 3.4.24.-) (COMPase) Adamts7 Rattus norvegicus (Rat) TR5801_c0_g1_i1 O95847 UCP4_HUMAN 2.00E-19 GO:0045177; GO:0035356; GO:0006091; GO:0048839; GO:0016021; GO:0005743; GO:0043066; GO:0070997; GO:0043025; GO:0008284; GO:0051562; GO:0006810 apical part of cell; cellular triglyceride homeostasis; generation of precursor metabolites and energy; inner ear development; integral to membrane; mitochondrial inner membrane; negative regulation of apoptotic process; neuron death; neuronal cell body; positive regulation of cell proliferation; reduction of mitochondrial calcium ion concentration; transport IPR018108; IPR023395; Mitochondrial uncoupling protein 4 (UCP 4) (Solute carrier family 25 member 27) SLC25A27 UCP4 UNQ772/PRO1566 Homo sapiens (Human) TR5805_c0_g1_i1 Q7Z5L0 VMO1_HUMAN 4.00E-45 GO:0005576; GO:0030704 extracellular region; vitelline membrane formation IPR005515; Vitelline membrane outer layer protein 1 homolog VMO1 UNQ6350/PRO21055 Homo sapiens (Human) TR5808_c0_g1_i1 Q9UFH2 DYH17_HUMAN 2.00E-43 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 17, axonemal (Axonemal beta dynein heavy chain 17) (Axonemal dynein heavy chain-like protein 1) (Ciliary dynein heavy chain 17) (Ciliary dynein heavy chain-like protein 1) (Dynein light chain 2, axonemal)" DNAH17 DNAHL1 DNEL2 Homo sapiens (Human) TR5808_c1_g1_i1 Q69Z23 DYH17_MOUSE 2.00E-44 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 17, axonemal (Axonemal beta dynein heavy chain 17) (Ciliary dynein heavy chain 17)" Dnah17 Dnahc17 Kiaa3028 Mus musculus (Mouse) TR583_c0_g1_i1 Q5THJ4 VP13D_HUMAN 2.00E-06 IPR009060; IPR015940; IPR000449; IPR026847; IPR026854; IPR009543; Vacuolar protein sorting-associated protein 13D VPS13D KIAA0453 Homo sapiens (Human) TR5838_c0_g2_i1 A7MBM2 DISP2_HUMAN 5.00E-06 GO:0016021; GO:0007224 integral to membrane; smoothened signaling pathway IPR000731; Protein dispatched homolog 2 DISP2 DISPB KIAA1742 Homo sapiens (Human) TR5840_c1_g1_i1 Q5BKI6 ANKR1_XENTR 1.00E-24 GO:0005634 nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 1 ankrd1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR5840_c4_g1_i1 Q68LP1 MIB2_RAT 2.00E-67 GO:0007219; GO:0005768; GO:0043123; GO:0004871; GO:0004842; GO:0008270 Notch signaling pathway; endosome; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding IPR002110; IPR020683; IPR010606; IPR001841; IPR013083; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (RBSC-skeletrophin/dystrophin-like polypeptide) Mib2 Rattus norvegicus (Rat) TR5843_c0_g2_i1 Q9IBG7 KCP_XENLA 3.00E-06 GO:0005576 extracellular region IPR008985; IPR001791; IPR002919; IPR014853; IPR001007; IPR001846; Kielin/chordin-like protein (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin) kcp crim2 Xenopus laevis (African clawed frog) TR5845_c0_g1_i1 P59511 ATS20_MOUSE 1.00E-09 GO:0030198; GO:0005615; GO:0004222; GO:0043066; GO:0045636; GO:0009967; GO:0005578; GO:0006508; GO:0008270 extracellular matrix organization; extracellular space; metalloendopeptidase activity; negative regulation of apoptotic process; positive regulation of melanocyte differentiation; positive regulation of signal transduction; proteinaceous extracellular matrix; proteolysis; zinc ion binding IPR010294; IPR024079; IPR012314; IPR001590; IPR013273; IPR002870; IPR000884; A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAM-TS 20) (ADAM-TS20) (ADAMTS-20) (EC 3.4.24.-) Adamts20 Mus musculus (Mouse) TR5845_c1_g1_i1 Q7SZD9 VM2US_GLOUS 1.00E-05 GO:0005576; GO:0004222; GO:0006508; GO:0008270 extracellular region; metalloendopeptidase activity; proteolysis; zinc ion binding IPR001762; IPR018358; IPR024079; IPR001590; IPR002870; Zinc metalloproteinase/disintegrin ussurin [Cleaved into: Snake venom metalloproteinase ussurin (SVMP) (EC 3.4.24.-); Disintegrin ussurin] Gloydius ussuriensis (Ussuri mamushi) (Gloydius blomhoffii ussuriensis) TR5848_c0_g1_i1 Q0MQD8 NDUB5_PANTR 1.00E-23 GO:0016021; GO:0005747; GO:0055114 integral to membrane; mitochondrial respiratory chain complex I; oxidation-reduction process IPR019173; "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (CI-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit)" NDUFB5 Pan troglodytes (Chimpanzee) TR5878_c0_g1_i1 Q5RFT1 CB018_PONAB 2.00E-09 GO:0016021; GO:0005765; GO:0005739; GO:1901029; GO:0008284; GO:0006810 integral to membrane; lysosomal membrane; mitochondrion; negative regulation of mitochondrial outer membrane permeabilization; positive regulation of cell proliferation; transport IPR009262; IPR012404; Solute carrier family 35 member F6 (ANT2-binding protein) (ANT2BP) (Transport and Golgi organization 9 homolog) SLC35F6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR5881_c1_g1_i1 Q62671 UBR5_RAT 4.00E-11 GO:0006281; GO:0003723; GO:0005737; GO:2000780; GO:1901315; GO:0005634; GO:0050847; GO:0042787; GO:0006974; GO:0004842; GO:0008270 DNA repair; RNA binding; cytoplasm; negative regulation of double-strand break repair; negative regulation of histone H2A K63-linked ubiquitination; nucleus; progesterone receptor signaling pathway; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; response to DNA damage stimulus; ubiquitin-protein ligase activity; zinc ion binding IPR024725; IPR000569; IPR002004; IPR009091; IPR003126; IPR013993; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase UBR5 (EC 6.3.2.-) (100 kDa protein) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog)" Ubr5 Dd5 Edd Edd1 Hyd Rattus norvegicus (Rat) TR5908_c0_g1_i1 Q5EAJ7 MVP_STRPU 1.00E-22 GO:0005737; GO:0005634; GO:0030529 cytoplasm; nucleus; ribonucleoprotein complex IPR000048; IPR021870; IPR002499; Major vault protein (MVP) MVP Strongylocentrotus purpuratus (Purple sea urchin) TR591_c0_g2_i1 P23935 NDUA5_BOVIN 7.00E-36 GO:0005747; GO:0016651; GO:0022904 "mitochondrial respiratory chain complex I; oxidoreductase activity, acting on NAD(P)H; respiratory electron transport chain" IPR006806; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (Complex I subunit B13) (Complex I-13kD-B) (CI-13kD-B) (NADH-ubiquinone oxidoreductase 13 kDa-B subunit) NDUFA5 Bos taurus (Bovine) TR5920_c1_g1_i1 P79098 AMPN_BOVIN 4.00E-15 GO:0004177; GO:0001525; GO:0030154; GO:0016021; GO:0008237; GO:0006508; GO:0009615; GO:0001618; GO:0008270 aminopeptidase activity; angiogenesis; cell differentiation; integral to membrane; metallopeptidase activity; proteolysis; response to virus; virus receptor activity; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (AP-N) (bAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) ANPEP APN Bos taurus (Bovine) TR5925_c1_g1_i1 Q80U28 MADD_MOUSE 3.00E-24 GO:0017112; GO:0000187; GO:0005737; GO:0097194; GO:0016021; GO:2001234; GO:0051726 Rab guanyl-nucleotide exchange factor activity; activation of MAPK activity; cytoplasm; execution phase of apoptosis; integral to membrane; negative regulation of apoptotic signaling pathway; regulation of cell cycle IPR005112; IPR001194; IPR005113; MAP kinase-activating death domain protein (Rab3 GDP/GTP exchange factor) Madd Kiaa0358 Mus musculus (Mouse) TR5925_c3_g1_i1 Q9VXY2 MADD_DROME 1.00E-22 GO:0017112; GO:0000187; GO:0006915; GO:0016021; GO:0007269; GO:0051726; GO:1902041; GO:0008021; GO:0016192 Rab guanyl-nucleotide exchange factor activity; activation of MAPK activity; apoptotic process; integral to membrane; neurotransmitter secretion; regulation of cell cycle; regulation of extrinsic apoptotic signaling pathway via death domain receptors; synaptic vesicle; vesicle-mediated transport IPR005112; IPR001194; IPR005113; MAP kinase-activating death domain protein (Rab3 guanyl-nucleotide exchange factor) rab3-GEF CG5627 Drosophila melanogaster (Fruit fly) TR5938_c0_g1_i1 Q24K15 ANGP4_BOVIN 1.00E-27 GO:0001525; GO:0005576 angiogenesis; extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) TR5949_c0_g1_i1 P27075 RL44_CANTR 3.00E-54 GO:0046677; GO:0046898; GO:0005840; GO:0003735; GO:0006412 response to antibiotic; response to cycloheximide; ribosome; structural constituent of ribosome; translation IPR000552; IPR011332; 60S ribosomal protein L44 (60S ribosomal protein L41) RPL44 CTL41 RIM-C RPL41 Candida tropicalis (Yeast) TR595_c0_g1_i1 P18172 DHGL_DROPS 9.00E-19 GO:0006066; GO:0008812; GO:0005576; GO:0050660 alcohol metabolic process; choline dehydrogenase activity; extracellular region; flavin adenine dinucleotide binding IPR012132; IPR000172; IPR007867; "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR5953_c0_g1_i1 O01761 UNC89_CAEEL 5.00E-06 GO:0005524; GO:0031430; GO:0005089; GO:0005543; GO:0004672; GO:0035023; GO:0030241 ATP binding; M band; Rho guanyl-nucleotide exchange factor activity; phospholipid binding; protein kinase activity; regulation of Rho protein signal transduction; skeletal muscle myosin thick filament assembly IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR007850; IPR001452; Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans TR5958_c0_g1_i1 P51523 ZNF84_HUMAN 4.00E-27 GO:0003677; GO:0005634; GO:0006355; GO:0006351; GO:0008270 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 84 (Zinc finger protein HPF2) ZNF84 Homo sapiens (Human) TR597_c0_g1_i1 Q6T269 IVBI3_BITGA 1.00E-09 GO:0005576; GO:0004867 extracellular region; serine-type endopeptidase inhibitor activity IPR002223; IPR020901; Protease inhibitor bitisilin-3 (Two-Kunitz protease inhibitor) (Fragment) Bitis gabonica (Gaboon adder) (Gaboon viper) TR5975_c0_g1_i1 Q9TUB5 CLCA1_PIG 1.00E-08 GO:0006816; GO:0005615 calcium ion transport; extracellular space IPR004727; IPR013642; IPR015394; IPR002035; Calcium-activated chloride channel regulator 1 (Calcium-activated chloride channel family member 1) (pCLCA1) CLCA1 AECC Sus scrofa (Pig) TR5976_c0_g1_i1 P41877 ISW1_CAEEL 5.00E-21 GO:0005524; GO:0043044; GO:0003677; GO:0003682; GO:0004386; GO:0007275; GO:0000790; GO:0040026; GO:0006355; GO:0006351 "ATP binding; ATP-dependent chromatin remodeling; DNA binding; chromatin binding; helicase activity; multicellular organismal development; nuclear chromatin; positive regulation of vulval development; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR017956; IPR014001; IPR001650; IPR009057; IPR015194; IPR027417; IPR001005; IPR017884; IPR015195; IPR000330; Chromatin-remodeling complex ATPase chain isw-1 (EC 3.6.4.-) (Nucleosome-remodeling factor subunit isw-1) isw-1 F37A4.8 Caenorhabditis elegans TR598_c0_g1_i1 O18017 BLM_CAEEL 4.00E-16 GO:0005524; GO:0043140; GO:0003677; GO:0000077; GO:0006281; GO:0006260; GO:0051276; GO:0008340; GO:0051307; GO:0007067; GO:0043066; GO:0005634; GO:0007131; GO:0010165 ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA binding; DNA damage checkpoint; DNA repair; DNA replication; chromosome organization; determination of adult lifespan; meiotic chromosome separation; mitosis; negative regulation of apoptotic process; nucleus; reciprocal meiotic recombination; response to X-ray IPR011545; IPR002464; IPR004589; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR018982; IPR011991; Bloom syndrome protein homolog (EC 3.6.4.12) (High incidence of males protein 6) (RecQ helicase homolog) him-6 T04A11.6 Caenorhabditis elegans TR5985_c1_g1_i1 P23098 DYHC_TRIGR 4.00E-32 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein beta chain, ciliary" Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla) TR5988_c0_g1_i1 Q03019 TWINE_DROME 2.00E-18 GO:0051301; GO:0009790; GO:0005622; GO:0007140; GO:0008315; GO:0051078; GO:0007279; GO:0004725; GO:0008138; GO:0051445; GO:0007348; GO:0007283 P23572 cell division; embryo development; intracellular; male meiosis; meiotic G2/MI transition; meiotic nuclear envelope disassembly; pole cell formation; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; regulation of meiotic cell cycle; regulation of syncytial blastoderm mitotic cell cycle; spermatogenesis IPR000751; IPR001763; Cdc25-like protein phosphatase twine (EC 3.1.3.48) twe CG4965 Drosophila melanogaster (Fruit fly) TR60_c0_g1_i1 Q460N5 PAR14_HUMAN 2.00E-18 GO:0003950; GO:0005737; GO:0005634; GO:0005886; GO:0006355; GO:0006351 "NAD+ ADP-ribosyltransferase activity; cytoplasm; nucleus; plasma membrane; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002589; IPR012317; IPR004170; Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) TR6013_c0_g1_i1 Q9BSW2 EFC4B_HUMAN 7.00E-09 GO:0005794; GO:0032237; GO:0005509; GO:0005730; GO:0051928; GO:0002115 P09022; Q96D31; Q13586 Golgi apparatus; activation of store-operated calcium channel activity; calcium ion binding; nucleolus; positive regulation of calcium ion transport; store-operated calcium entry IPR011992; IPR018247; IPR002048; EF-hand calcium-binding domain-containing protein 4B (Calcium release-activated calcium channel regulator 2A) (CRAC channel regulator 2A) EFCAB4B CRACR2A Homo sapiens (Human) TR6022_c0_g1_i1 P70194 CLC4F_MOUSE 2.00E-08 GO:0030246; GO:0006897; GO:0016021 carbohydrate binding; endocytosis; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13) (Kupffer cell receptor) Clec4f Clecsf13 Kclr Mus musculus (Mouse) TR6031_c0_g1_i1 Q9VWH4 IDH3A_DROME 1.00E-33 GO:0051287; GO:0004449; GO:0005811; GO:0000287; GO:0005875; GO:0005739; GO:0006099 NAD binding; isocitrate dehydrogenase (NAD+) activity; lipid particle; magnesium ion binding; microtubule associated complex; mitochondrion; tricarboxylic acid cycle IPR019818; IPR001804; IPR004434; IPR024084; "Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha)" l(1)G0156 CG12233 Drosophila melanogaster (Fruit fly) TR6032_c1_g1_i1 Q8NHV1 GIMA7_HUMAN 3.00E-18 GO:0005525; GO:0003924; GO:0005811 GTP binding; GTPase activity; lipid particle IPR006703; IPR027417; GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) TR6034_c0_g2_i1 Q9JIC3 DCR1A_MOUSE 6.00E-18 GO:0051301; GO:0016787; GO:0007067; GO:0006289; GO:0005634 cell division; hydrolase activity; mitosis; nucleotide-excision repair; nucleus IPR001279; IPR011084; DNA cross-link repair 1A protein (SNM1 homolog A) Dclre1a Kiaa0086 Snm1 Snm1a Mus musculus (Mouse) TR6042_c0_g1_i1 P69152 H4_TETTS 7.00E-38 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR001951; IPR019809; Histone H4 HHF1 TTHERM_00498190; HHF2 TTHERM_00189170 Tetrahymena thermophila (strain SB210) TR6045_c0_g1_i1 O43301 HS12A_HUMAN 4.00E-16 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR6050_c0_g2_i1 Q5M954 SEN2_RAT 3.00E-11 GO:0006397; GO:0003676; GO:0090305; GO:0005730; GO:0006388; GO:0000213; GO:0000214 "mRNA processing; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis; nucleolus; tRNA splicing, via endonucleolytic cleavage and ligation; tRNA-intron endonuclease activity; tRNA-intron endonuclease complex" IPR011856; IPR006677; IPR006678; IPR016589; tRNA-splicing endonuclease subunit Sen2 (EC 3.1.27.9) (tRNA-intron endonuclease Sen2) Tsen2 Rattus norvegicus (Rat) TR6051_c0_g1_i1 Q4R4R0 PRS7_MACFA 9.00E-43 GO:0005524; GO:0016887; GO:0000932; GO:0005634; GO:0022624; GO:0006511 ATP binding; ATPase activity; cytoplasmic mRNA processing body; nucleus; proteasome accessory complex; ubiquitin-dependent protein catabolic process IPR005937; IPR003593; IPR003959; IPR003960; IPR027417; 26S protease regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) PSMC2 QnpA-16482 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR6053_c1_g1_i1 Q6P1J0 MANEL_MOUSE 5.00E-25 GO:0000139; GO:0016787; GO:0016021 Golgi membrane; hydrolase activity; integral to membrane IPR026071; "Glycoprotein endo-alpha-1,2-mannosidase-like protein (EC 3.2.1.-)" Maneal Gm50 Mus musculus (Mouse) TR6056_c0_g1_i1 B4LMK1 KTU_DROVI 3.00E-58 GO:0005737 cytoplasm IPR012981; "Protein kintoun (Dynein assembly factor 2, axonemal homolog) (PP1-interacting protein 20)" Ppi20 GJ21124 Drosophila virilis (Fruit fly) TR606_c0_g1_i1 Q5U4Z8 RM20_XENLA 5.00E-26 GO:0005739; GO:0019843; GO:0005840; GO:0003735; GO:0006412 mitochondrion; rRNA binding; ribosome; structural constituent of ribosome; translation IPR005813; "39S ribosomal protein L20, mitochondrial (L20mt) (MRP-L20)" mrpl20 Xenopus laevis (African clawed frog) TR6065_c0_g1_i1 Q0EEE2 PTHD3_MOUSE 2.00E-13 GO:0008158; GO:0016021 hedgehog receptor activity; integral to membrane IPR003392; IPR000731; Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) TR6069_c1_g1_i1 P56537 IF6_HUMAN 1.00E-54 GO:0005737; GO:0005638; GO:0042256; GO:0005634; GO:0043022; GO:0003743 Q96C10; P19525; Q16612; Q9Y6K5; P68404 cytoplasm; lamin filament; mature ribosome assembly; nucleus; ribosome binding; translation initiation factor activity IPR002769; Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP)) EIF6 EIF3A ITGB4BP OK/SW-cl.27 Homo sapiens (Human) TR6079_c2_g1_i1 Q8VD04 GRAP1_MOUSE 1.00E-11 GO:0005769 A3KBF5 early endosome IPR026204; GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein) Gripap1 DXImx47e Kiaa1167 Mus musculus (Mouse) TR6080_c0_g1_i1 P10666 KS6AB_XENLA 4.00E-41 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR000961; IPR011009; IPR017892; IPR000719; IPR017441; IPR002290; IPR008271; Ribosomal protein S6 kinase 2 beta (EC 2.7.11.1) (Ribosomal protein S6 kinase II beta) (S6KII-beta) (p90-RSK) Xenopus laevis (African clawed frog) TR6080_c0_g2_i1 Q4KTY1 KPSH1_PINFU 0 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR020636; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1) PSKH1 Pinctada fucata (Pearl oyster) TR6101_c0_g1_i1 Q8VCN5 CGL_MOUSE 4.00E-32 GO:0080146; GO:0044540; GO:0004123; GO:0019344; GO:0005737; GO:0070814; GO:0043066; GO:2001234; GO:0005634; GO:0043123; GO:0051092; GO:0051289; GO:0044524; GO:0018272; GO:0030170 L-cysteine desulfhydrase activity; L-cystine L-cysteine-lyase (deaminating); cystathionine gamma-lyase activity; cysteine biosynthetic process; cytoplasm; hydrogen sulfide biosynthetic process; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; protein homotetramerization; protein sulfhydration; protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; pyridoxal phosphate binding IPR000277; IPR015424; IPR015421; IPR015422; Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2. Cystathionine gamma-lyase (EC 4.4.1.1) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) Cth Mus musculus (Mouse) TR6103_c0_g1_i1 Q54HW1 PSD10_DICDI 2.00E-12 IPR002110; IPR020683; 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) psmD10 DDB_G0289189 Dictyostelium discoideum (Slime mold) TR6114_c1_g1_i1 Q6UVM3 KCNT2_HUMAN 4.00E-24 GO:0005524; GO:0015269; GO:0005249; GO:0008076 ATP binding; calcium-activated potassium channel activity; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR013099; IPR003929; IPR016040; Potassium channel subfamily T member 2 (Sequence like an intermediate conductance potassium channel subunit) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1) KCNT2 SLICK Homo sapiens (Human) TR6122_c1_g1_i1 Q9M5Z9 RS23_EUPES 8.00E-34 GO:0015935; GO:0003735; GO:0006412 small ribosomal subunit; structural constituent of ribosome; translation IPR012340; IPR006032; IPR005680; 40S ribosomal protein S23 RPS23 Euphorbia esula (Leafy spurge) TR6139_c0_g1_i1 H2A0M7 PLSP_PINMG 3.00E-25 GO:0005576; GO:0020037; GO:0004601; GO:0006979 extracellular region; heme binding; peroxidase activity; response to oxidative stress IPR010255; IPR002007; IPR019791; Peroxidase-like protein Pinctada margaritifera (Black-lipped pearl oyster) TR6139_c0_g2_i1 Q23490 MLT7_CAEEL 1.00E-21 GO:0042338; GO:0020037; GO:0046872; GO:0002119; GO:0018149; GO:0004601; GO:0040032; GO:0006979 cuticle development involved in collagen and cuticulin-based cuticle molting cycle; heme binding; metal ion binding; nematode larval development; peptide cross-linking; peroxidase activity; post-embryonic body morphogenesis; response to oxidative stress IPR010255; IPR002007; IPR019791; IPR003582; Peroxidase mlt-7 (EC 1.11.1.7) (Molting defective protein 7) (MoLT-7) [Cleaved into: Peroxidase mlt-7 light chain; Peroxidase mlt-7 heavy chain] mlt-7 ZK430.8 Caenorhabditis elegans TR6153_c0_g1_i1 Q99M80 PTPRT_MOUSE 4.00E-12 GO:0051393; GO:0045294; GO:0008013; GO:0009986; GO:0007156; GO:0016021; GO:0005886; GO:0004725; GO:0016790; GO:0007169 alpha-actinin binding; alpha-catenin binding; beta-catenin binding; cell surface; homophilic cell adhesion; integral to membrane; plasma membrane; protein tyrosine phosphatase activity; thiolester hydrolase activity; transmembrane receptor protein tyrosine kinase signaling pathway IPR008985; IPR003961; IPR007110; IPR013783; IPR003599; IPR000998; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) TR6154_c0_g1_i1 Q80TY5 VP13B_MOUSE 1.00E-16 GO:0015031 protein transport IPR015412; IPR026854; IPR009543; Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1 homolog) Vps13b Coh1 Kiaa0532 Mus musculus (Mouse) TR6162_c0_g1_i1 Q8N9N2 ASCC1_HUMAN 4.00E-08 GO:0003723; GO:0003824; GO:0005737; GO:0006355; GO:0005667; GO:0006351 "RNA binding; catalytic activity; cytoplasm; regulation of transcription, DNA-dependent; transcription factor complex; transcription, DNA-dependent" IPR009210; IPR004087; IPR004088; IPR019510; IPR009097; Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50) ASCC1 CGI-18 Homo sapiens (Human) TR6171_c0_g1_i1 Q9VCA8 ANKHM_DROME 4.00E-12 GO:0003723; GO:0019730; GO:0051298; GO:0001751; GO:0005811; GO:0043066; GO:0046427; GO:0007169 RNA binding; antimicrobial humoral response; centrosome duplication; compound eye photoreceptor cell differentiation; lipid particle; negative regulation of apoptotic process; positive regulation of JAK-STAT cascade; transmembrane receptor protein tyrosine kinase signaling pathway IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) TR6175_c0_g1_i1 P20262 GLRK_LITBE 9.00E-10 GO:0030054; GO:0005234; GO:0016021; GO:0004970; GO:0035235; GO:0045211 cell junction; extracellular-glutamate-gated ion channel activity; integral to membrane; ionotropic glutamate receptor activity; ionotropic glutamate receptor signaling pathway; postsynaptic membrane IPR019594; IPR001320; IPR001508; Probable glutamate receptor (Kainate-binding protein) (KBP) Lithobates berlandieri (Rio Grande leopard frog) (Rana berlandieri) TR6176_c0_g1_i1 P24367 PPIB_CHICK 1.00E-40 GO:0005788; GO:0042277; GO:0003755; GO:0006457; GO:0000413 endoplasmic reticulum lumen; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB Gallus gallus (Chicken) TR618_c0_g1_i1 Q9V3P0 PRDX1_DROME 2.00E-92 GO:0007155; GO:0045454; GO:0005829; GO:0008340; GO:0007281; GO:0008354; GO:0042744; GO:0005875; GO:0006974; GO:0042594; GO:0008379 P11956 cell adhesion; cell redox homeostasis; cytosol; determination of adult lifespan; germ cell development; germ cell migration; hydrogen peroxide catabolic process; microtubule associated complex; response to DNA damage stimulus; response to starvation; thioredoxin peroxidase activity IPR000866; IPR024706; IPR019479; IPR012336; Peroxiredoxin 1 (EC 1.11.1.15) (Cytosolic thioredoxin peroxidase) (DPx-4783) (DmTPx-1) (Thioredoxin peroxidase) Jafrac1 TPX-1 CG1633 Drosophila melanogaster (Fruit fly) TR6196_c0_g1_i1 Q96RW7 HMCN1_HUMAN 7.00E-08 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR6221_c0_g1_i1 P41436 IAP_GVCPM 2.00E-16 GO:0006915; GO:0008270 apoptotic process; zinc ion binding IPR001370; IPR001841; Apoptosis inhibitor IAP IAP Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) TR6223_c1_g1_i1 O93477 SAHHB_XENLA 5.00E-40 GO:0004013; GO:0006730 adenosylhomocysteinase activity; one-carbon metabolic process IPR000043; IPR015878; IPR016040; IPR020082; Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. Adenosylhomocysteinase B (AdoHcyase B) (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase B) ahcy-b ahcy2 sahh Xenopus laevis (African clawed frog) TR6238_c0_g1_i1 Q10074 AVT3_SCHPO 3.00E-06 GO:0034639; GO:0032974; GO:0006995; GO:0005783; GO:0005789; GO:0000329; GO:0016021; GO:0030435 L-amino acid efflux transmembrane transporter activity; amino acid transmembrane export from vacuole; cellular response to nitrogen starvation; endoplasmic reticulum; endoplasmic reticulum membrane; fungal-type vacuole membrane; integral to membrane; sporulation resulting in formation of a cellular spore IPR013057; Vacuolar amino acid transporter 3 avt3 SPAC3H1.09c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR6249_c0_g1_i1 Q8N8E3 CE112_HUMAN 5.00E-29 GO:0005813; GO:0005737; GO:0060077; GO:0005886; GO:0097120 centrosome; cytoplasm; inhibitory synapse; plasma membrane; receptor localization to synapse IPR027831; Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46) CEP112 CCDC46 Homo sapiens (Human) TR6257_c0_g1_i1 O75830 SPI2_HUMAN 2.00E-19 GO:0006928; GO:0005615; GO:0030162; GO:0004867 Q9UMX0 cellular component movement; extracellular space; regulation of proteolysis; serine-type endopeptidase inhibitor activity IPR023795; IPR023796; IPR000215; Serpin I2 (Myoepithelium-derived serine protease inhibitor) (Pancpin) (Pancreas-specific protein TSA2004) (Peptidase inhibitor 14) (PI-14) SERPINI2 MEPI PI14 Homo sapiens (Human) TR6276_c0_g2_i1 Q8BXA7 PHLP2_MOUSE 8.00E-14 GO:0005737; GO:0016020; GO:0008152; GO:0046872; GO:0005634; GO:0004721 cytoplasm; membrane; metabolic process; metal ion binding; nucleus; phosphoprotein phosphatase activity IPR001611; IPR025875; IPR003591; IPR011993; IPR001932; PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like) Phlpp2 Phlppl Mus musculus (Mouse) TR6286_c1_g2_i1 Q80SU7 GVIN1_MOUSE 6.00E-45 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR027417; Interferon-induced very large GTPase 1 (Very large-inducible GTPase-1) (VLIG-1) Gvin1 Mus musculus (Mouse) TR6287_c1_g1_i1 Q5R8W6 LC7L3_PONAB 2.00E-06 GO:0003677; GO:0008380; GO:0005685; GO:0003729; GO:0006376; GO:0016607; GO:0005634 DNA binding; RNA splicing; U1 snRNP; mRNA binding; mRNA splice site selection; nuclear speck; nucleus IPR004882; Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) LUC7L3 CROP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR6288_c1_g1_i1 P35590 TIE1_HUMAN 2.00E-06 GO:0005524; GO:0001525; GO:0001701; GO:0005887; GO:0007498; GO:0016525; GO:0030336; GO:0045026; GO:0032526; GO:0004714 Q15238 ATP binding; angiogenesis; in utero embryonic development; integral to plasma membrane; mesoderm development; negative regulation of angiogenesis; negative regulation of cell migration; plasma membrane fusion; response to retinoic acid; transmembrane receptor protein tyrosine kinase activity IPR000742; IPR013032; IPR003961; IPR013783; IPR003599; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE Homo sapiens (Human) TR6301_c0_g1_i1 Q5ZIA5 COPB_CHICK 8.00E-45 GO:0030126; GO:0006886; GO:0005198; GO:0016192 COPI vesicle coat; intracellular protein transport; structural molecule activity; vesicle-mediated transport IPR011989; IPR016024; IPR002553; IPR011710; IPR016460; Coatomer subunit beta (Beta-coat protein) (Beta-COP) COPB1 COPB RCJMB04_28l17 Gallus gallus (Chicken) TR6303_c0_g1_i1 Q5T197 DCST1_HUMAN 4.00E-06 GO:0016021; GO:0008270 integral to membrane; zinc ion binding IPR012858; IPR001841; DC-STAMP domain-containing protein 1 DCST1 Homo sapiens (Human) TR6321_c0_g1_i1 P79398 IF4G2_RABIT 5.00E-17 GO:0016281; GO:0006446; GO:0003743 eukaryotic translation initiation factor 4F complex; regulation of translational initiation; translation initiation factor activity IPR016024; IPR003891; IPR016021; IPR003890; IPR003307; Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Novel APOBEC-1 target 1) (Translation repressor NAT1) (p97) EIF4G2 NAT1 Oryctolagus cuniculus (Rabbit) TR633_c0_g1_i1 Q9NVD3 SETD4_HUMAN 2.00E-55 GO:0008168 methyltransferase activity IPR016852; IPR015353; IPR001214; SET domain-containing protein 4 (EC 2.1.1.-) SETD4 C21orf18 C21orf27 Homo sapiens (Human) TR633_c0_g2_i1 Q91WC0 SETD3_MOUSE 2.00E-19 GO:0046975; GO:0042800; GO:0000790; GO:0018027; GO:0018026; GO:0018023; GO:0051149; GO:0045944; GO:0003713; GO:0006351 "histone methyltransferase activity (H3-K36 specific); histone methyltransferase activity (H3-K4 specific); nuclear chromatin; peptidyl-lysine dimethylation; peptidyl-lysine monomethylation; peptidyl-lysine trimethylation; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; transcription, DNA-dependent" IPR025785; IPR015353; IPR001214; Histone-lysine N-methyltransferase setd3 (EC 2.1.1.43) (Endothelial differentiation inhibitory protein D10) (SET domain-containing protein 3) Setd3 D12Ertd771e Mus musculus (Mouse) TR6339_c0_g1_i1 A4IFI1 CC157_BOVIN 3.00E-12 Coiled-coil domain-containing protein 157 CCDC157 Bos taurus (Bovine) TR635_c0_g1_i1 Q8MPM1 GELS2_LUMTE 3.00E-24 GO:0051693; GO:0005737; GO:0005856 actin filament capping; cytoplasm; cytoskeleton IPR007123; IPR007122; Gelsolin-like protein 2 (Actin-modulator) (EWAM-P2) gelsolin Lumbricus terrestris (Common earthworm) TR6350_c0_g3_i1 Q9UT67 IMT2_SCHPO 3.00E-09 GO:0005794; GO:0033106; GO:0007038; GO:0006897; GO:0016021; GO:0051999; GO:0000030; GO:0031501; GO:0032588 Golgi apparatus; cis-Golgi network membrane; endocytosed protein transport to vacuole; endocytosis; integral to membrane; mannosyl-inositol phosphorylceramide biosynthetic process; mannosyltransferase activity; mannosyltransferase complex; trans-Golgi network membrane IPR007577; Inositol phosphoceramide mannosyltransferase 2 (EC 2.4.-.-) (IPC mannosyltransferase 2) SPCC4F11.04c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR6358_c0_g1_i1 P36975 SNP25_DROME 7.00E-25 GO:0006893; GO:0005484; GO:0031201; GO:0030054; GO:0043005; GO:0005886; GO:0048172; GO:0045202; GO:0016081; GO:0016082 Golgi to plasma membrane transport; SNAP receptor activity; SNARE complex; cell junction; neuron projection; plasma membrane; regulation of short-term neuronal synaptic plasticity; synapse; synaptic vesicle docking involved in exocytosis; synaptic vesicle priming IPR000928; IPR000727; Synaptosomal-associated protein 25 (SNAP-25) (Synaptosomal-associated 25 kDa protein) Snap25 CG40452 Drosophila melanogaster (Fruit fly) TR636_c0_g1_i1 Q7Z2Y8 GVIN1_HUMAN 2.00E-07 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR027417; Interferon-induced very large GTPase 1 (Interferon-induced very large GTPase pseudogene 1) GVINP1 GVIN1 Homo sapiens (Human) TR6375_c0_g2_i1 B1AYB6 MBD5_MOUSE 3.00E-06 GO:0003682; GO:0005694; GO:0042593; GO:0005634; GO:0060399; GO:0040014 chromatin binding; chromosome; glucose homeostasis; nucleus; positive regulation of growth hormone receptor signaling pathway; regulation of multicellular organism growth IPR001739; Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5) Mbd5 Mus musculus (Mouse) TR6377_c1_g1_i1 P15870 H1D_STRPU 2.00E-19 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR005818; IPR005819; IPR011991; Histone H1-delta Strongylocentrotus purpuratus (Purple sea urchin) TR638_c0_g1_i1 Q1PSW8 LIN41_MOUSE 7.00E-24 GO:0000082; GO:0000932; GO:0008543; GO:0035198; GO:0010586; GO:0035278; GO:0001843; GO:2000637; GO:0051865; GO:2000177; GO:0072089; GO:0004842; GO:0008270 G1/S transition of mitotic cell cycle; cytoplasmic mRNA processing body; fibroblast growth factor receptor signaling pathway; miRNA binding; miRNA metabolic process; negative regulation of translation involved in gene silencing by miRNA; neural tube closure; positive regulation of gene silencing by miRNA; protein autoubiquitination; regulation of neural precursor cell proliferation; stem cell proliferation; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (mLin41) (Tripartite motif-containing protein 71) Trim71 Gm1127 Lin41 Mus musculus (Mouse) TR6398_c0_g1_i1 Q0P4M4 CBPC2_XENTR 2.00E-46 GO:0005829; GO:0004181; GO:0006508; GO:0008270 cytosol; metallocarboxypeptidase activity; proteolysis; zinc ion binding IPR000834; Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) agbl2 ccp2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR6398_c1_g1_i1 Q9VY99 NNAD_DROME 7.00E-40 GO:0002164; GO:0004181; GO:0005739; GO:0007005; GO:0003407; GO:0006508; GO:0008270 larval development; metallocarboxypeptidase activity; mitochondrion; mitochondrion organization; neural retina development; proteolysis; zinc ion binding IPR000834; Cytosolic carboxypeptidase NnaD (EC 3.4.17.-) (Nervous system nuclear protein induced by axotomy protein 1 homolog) NnaD CG44533 Drosophila melanogaster (Fruit fly) TR64_c0_g2_i1 Q80UU1 ANKZ1_MOUSE 1.00E-10 GO:0046872 metal ion binding IPR002110; IPR020683; IPR007087; Ankyrin repeat and zinc finger domain-containing protein 1 Ankzf1 D1Ertd161e Mus musculus (Mouse) TR6401_c1_g1_i1 P62283 ASPM_AOTVO 9.00E-22 GO:0051301; GO:0005737; GO:0007067; GO:0005634 cell division; cytoplasm; mitosis; nucleus IPR016024; IPR022613; IPR001715; IPR000048; IPR027417; Abnormal spindle-like microcephaly-associated protein homolog ASPM Aotus vociferans (Spix's owl monkey) (Noisy night monkey) TR6405_c0_g1_i1 Q8S8T8 PCR10_ARATH 3.00E-06 GO:0016021 integral to membrane IPR006461; Protein PLANT CADMIUM RESISTANCE 10 (AtPCR10) PCR10 At2g40935 T20B5 Arabidopsis thaliana (Mouse-ear cress) TR6407_c0_g2_i1 Q96GP6 SREC2_HUMAN 1.00E-19 GO:0007157; GO:0016021; GO:0005044 P16333 heterophilic cell-cell adhesion; integral to membrane; scavenger receptor activity IPR000742; IPR013032; IPR002049; IPR009030; Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) TR6411_c0_g1_i1 Q5RAH1 NCALD_PONAB 2.00E-27 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Neurocalcin-delta NCALD Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR6411_c0_g2_i1 Q84MN0 CML4_ORYSJ 1.00E-07 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-like protein 4 CML4 Os03g0743500 LOC_Os03g53200 OSJNBb0036F07.4 Oryza sativa subsp. japonica (Rice) TR6428_c1_g1_i1 P28492 GLSL_RAT 6.00E-10 GO:0004359; GO:0006541; GO:0005759; GO:0072593; GO:0042981 glutaminase activity; glutamine metabolic process; mitochondrial matrix; reactive oxygen species metabolic process; regulation of apoptotic process IPR002110; IPR020683; IPR012338; IPR015868; "Glutaminase liver isoform, mitochondrial (GLS) (EC 3.5.1.2) (L-glutaminase) (L-glutamine amidohydrolase)" Gls2 Ga Rattus norvegicus (Rat) TR6438_c0_g2_i1 Q5RJF7 CA2D4_MOUSE 2.00E-17 GO:0005262; GO:0016021; GO:0046872; GO:0005244 calcium channel activity; integral to membrane; metal ion binding; voltage-gated ion channel activity IPR004010; IPR013608; IPR002035; Voltage-dependent calcium channel subunit alpha-2/delta-4 (Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4] Cacna2d4 Mus musculus (Mouse) TR6440_c0_g1_i1 Q5Y4N8 EMR1_RAT 2.00E-09 GO:0004930; GO:0005509; GO:0009897; GO:0016021; GO:0007218 G-protein coupled receptor activity; calcium ion binding; external side of plasma membrane; integral to membrane; neuropeptide signaling pathway IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR017981; IPR001740; IPR000832; IPR017983; IPR000203; IPR009030; EGF-like module-containing mucin-like hormone receptor-like 1 (EGF-like module receptor 1) (EMR1 hormone receptor) Emr1 Rattus norvegicus (Rat) TR6443_c0_g1_i1 Q5RJI4 PKDCC_MOUSE 3.00E-06 GO:0005524; GO:0005794; GO:0030282; GO:0030154; GO:0048566; GO:0048286; GO:0035264; GO:0042997; GO:0060021; GO:0030501; GO:0032332; GO:0004672; GO:0015031; GO:0001501 ATP binding; Golgi apparatus; bone mineralization; cell differentiation; embryonic digestive tract development; lung alveolus development; multicellular organism growth; negative regulation of Golgi to plasma membrane protein transport; palate development; positive regulation of bone mineralization; positive regulation of chondrocyte differentiation; protein kinase activity; protein transport; skeletal system development IPR022049; IPR011009; IPR000719; "Protein kinase domain-containing protein, cytoplasmic (EC 2.7.-.-) (Protein kinase-like protein SgK493) (Sugen kinase 493) (Vertebrate lonesome kinase)" Pkdcc Sgk493 Vlk Mus musculus (Mouse) TR6456_c0_g2_i1 A0JM59 UBP20_XENTR 3.00E-18 GO:0005813; GO:0004197; GO:0006897; GO:0048471; GO:0071108; GO:0070536; GO:0008277; GO:0004221; GO:0006511; GO:0008270 centrosome; cysteine-type endopeptidase activity; endocytosis; perinuclear region of cytoplasm; protein K48-linked deubiquitination; protein K63-linked deubiquitination; regulation of G-protein coupled receptor protein signaling pathway; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; zinc ion binding IPR006615; IPR018200; IPR001394; IPR013083; IPR001607; Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) usp20 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR6465_c0_g1_i1 Q96JL9 ZN333_HUMAN 2.00E-06 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 333 ZNF333 KIAA1806 Homo sapiens (Human) TR6468_c0_g1_i1 Q965W1 FABP9_CAEEL 4.00E-16 GO:0008289; GO:0005215 lipid binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; Fatty acid-binding protein homolog 9 lbp-9 Y40B10A.1 Caenorhabditis elegans TR6468_c0_g2_i1 O01812 FABP6_CAEEL 6.00E-23 GO:0008289; GO:0005215 P34629 lipid binding; transporter activity IPR012674; IPR011038; IPR000463; IPR000566; Fatty acid-binding protein homolog 6 lbp-6 W02D3.5 Caenorhabditis elegans TR648_c0_g1_i1 Q9VE46 SC5A7_DROME 7.00E-50 GO:0008292; GO:0015171; GO:0015220; GO:0016021; GO:0006814; GO:0015293 acetylcholine biosynthetic process; amino acid transmembrane transporter activity; choline transmembrane transporter activity; integral to membrane; sodium ion transport; symporter activity IPR001734; High-affinity choline transporter 1 CG7708 Drosophila melanogaster (Fruit fly) TR6486_c1_g1_i1 Q08CY1 KLH22_XENTR 1.00E-12 GO:0031463; GO:0051301; GO:0005813; GO:0005737; GO:0000070; GO:0072686; GO:0007094; GO:0005827; GO:0006513 Cul3-RING ubiquitin ligase complex; cell division; centrosome; cytoplasm; mitotic sister chromatid segregation; mitotic spindle; mitotic spindle assembly checkpoint; polar microtubule; protein monoubiquitination IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 22 klhl22 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR6489_c0_g1_i1 Q9FNI6 SM3L2_ARATH 9.00E-06 GO:0005524; GO:0003677; GO:0009294; GO:0016568; GO:0045003; GO:0004386; GO:0005634; GO:0008270 ATP binding; DNA binding; DNA mediated transformation; chromatin modification; double-strand break repair via synthesis-dependent strand annealing; helicase activity; nucleus; zinc ion binding IPR014001; IPR001650; IPR014905; IPR027417; IPR000330; IPR018957; IPR001841; IPR013083; IPR017907; Putative SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3-like 2 (SMARCA3-like protein 2) (EC 3.6.4.-) At5g22750 MDJ22.17 Arabidopsis thaliana (Mouse-ear cress) TR6489_c0_g2_i1 Q6PJ69 TRI65_HUMAN 1.00E-07 GO:0005622; GO:0008270 intracellular; zinc ion binding IPR001870; IPR003879; IPR008985; IPR003877; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Tripartite motif-containing protein 65 TRIM65 Homo sapiens (Human) TR6491_c0_g1_i1 Q9NBX4 RTXE_DROME 8.00E-07 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR65_c0_g1_i1 O75592 MYCB2_HUMAN 5.00E-15 GO:0030424; GO:0021785; GO:0021952; GO:0015630; GO:0005634; GO:0051493; GO:0032880; GO:0006355; GO:0006351; GO:0004842; GO:0008270 Q99IB8 "axon; branchiomotor neuron axon guidance; central nervous system projection neuron axonogenesis; microtubule cytoskeleton; nucleus; regulation of cytoskeleton organization; regulation of protein localization; regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-protein ligase activity; zinc ion binding" IPR004939; IPR017868; IPR008979; IPR027047; IPR013783; IPR014756; IPR012983; IPR009091; IPR000408; IPR003646; IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc) MYCBP2 KIAA0916 PAM Homo sapiens (Human) TR6506_c0_g1_i1 Q9H0I2 CP048_HUMAN 2.00E-06 GO:0005881 cytoplasmic microtubule IPR027710; IPR027012; Enkurin domain-containing protein 1 ENKD1 C16orf48 UNQ6410/PRO21183 Homo sapiens (Human) TR6521_c0_g1_i1 Q7TNK0 SERC1_RAT 4.00E-13 GO:0015194; GO:0005789; GO:0016021; GO:0006658; GO:0008654; GO:0005886; GO:0051347; GO:0006665 L-serine transmembrane transporter activity; endoplasmic reticulum membrane; integral to membrane; phosphatidylserine metabolic process; phospholipid biosynthetic process; plasma membrane; positive regulation of transferase activity; sphingolipid metabolic process IPR005016; Serine incorporator 1 (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2) Serinc1 Tde1l Tde2 Rattus norvegicus (Rat) TR6544_c1_g1_i1 P20651 PP2BB_RAT 9.00E-07 GO:0005955; GO:0005509; GO:0017156; GO:0005516; GO:0033192; GO:0035690; GO:0005829; GO:0008144; GO:0046716; GO:0005886; GO:0035774; GO:0006470; GO:0046982; GO:0030346; GO:0006468; GO:0001975 Q9WVC7 calcineurin complex; calcium ion binding; calcium ion-dependent exocytosis; calmodulin binding; calmodulin-dependent protein phosphatase activity; cellular response to drug; cytosol; drug binding; muscle cell cellular homeostasis; plasma membrane; positive regulation of insulin secretion involved in cellular response to glucose stimulus; protein dephosphorylation; protein heterodimerization activity; protein phosphatase 2B binding; protein phosphorylation; response to amphetamine IPR004843; IPR006186; Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) Ppp3cb Rattus norvegicus (Rat) TR6547_c0_g1_i1 Q9Z2H5 E41L1_MOUSE 4.00E-26 GO:0030866; GO:0005737; GO:0005856; GO:0019898; GO:0005198 cortical actin cytoskeleton organization; cytoplasm; cytoskeleton; extrinsic to membrane; structural molecule activity IPR008379; IPR019749; IPR019750; IPR021187; IPR000798; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; IPR007477; Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N) Epb41l1 Epb4 Epb4.1l1 Kiaa0338 Mus musculus (Mouse) TR6551_c0_g1_i1 P04751 ACTC_XENLA 2.00E-28 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin, alpha cardiac muscle 1 (Actin alpha 1) (Alpha-cardiac actin)" actc1 acta1 actc Xenopus laevis (African clawed frog) TR6571_c0_g1_i1 P48554 RAC2_DROME 1.00E-32 GO:0005525; GO:0003924; GO:0007254; GO:0007266; GO:0051017; GO:0034334; GO:0042742; GO:0007394; GO:0007390; GO:0008258; GO:0035099; GO:0002433; GO:0005622; GO:0030032; GO:0046331; GO:0035011; GO:0007520; GO:0005886; GO:0050770; GO:0007435; GO:0007426 Q24213 "GTP binding; GTPase activity; JNK cascade; Rho protein signal transduction; actin filament bundle assembly; adherens junction maintenance; defense response to bacterium; dorsal closure, elongation of leading edge cells; germ-band shortening; head involution; hemocyte migration; immune response-regulating cell surface receptor signaling pathway involved in phagocytosis; intracellular; lamellipodium assembly; lateral inhibition; melanotic encapsulation of foreign target; myoblast fusion; plasma membrane; regulation of axonogenesis; salivary gland morphogenesis; tracheal outgrowth, open tracheal system" IPR027417; IPR005225; IPR001806; IPR003578; Ras-related protein Rac2 Rac2 RacB CG8556 Drosophila melanogaster (Fruit fly) TR6580_c0_g1_i1 O75795 UDB17_HUMAN 1.00E-17 GO:0005789; GO:0015020; GO:0016021; GO:0016020; GO:0008202 endoplasmic reticulum membrane; glucuronosyltransferase activity; integral to membrane; membrane; steroid metabolic process IPR002213; UDP-glucuronosyltransferase 2B17 (UDPGT 2B17) (EC 2.4.1.17) (C19-steroid-specific UDP-glucuronosyltransferase) (C19-steroid-specific UDPGT) UGT2B17 Homo sapiens (Human) TR6604_c1_g1_i1 Q55EH8 ABCGN_DICDI 9.00E-18 GO:0005524; GO:0006200; GO:0016887; GO:0016021; GO:0006810 ATP binding; ATP catabolic process; ATPase activity; integral to membrane; transport IPR003593; IPR003439; IPR017871; IPR027417; ABC transporter G family member 23 (ABC transporter ABCG.23) abcG23 DDB_G0269026 Dictyostelium discoideum (Slime mold) TR6605_c0_g1_i1 Q4R6N0 TPTE2_MACFA 1.00E-31 GO:0005789; GO:0016021; GO:0005216; GO:0035335; GO:0016314; GO:0004725; GO:0008138 "endoplasmic reticulum membrane; integral to membrane; ion channel activity; peptidyl-tyrosine dephosphorylation; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity" IPR000008; IPR000340; IPR005821; IPR014019; IPR014020; IPR016130; "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67)" TPTE2 QtsA-17567 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR6605_c0_g2_i1 Q9PUT6 PTEN_XENLA 2.00E-07 GO:0030165; GO:0016605; GO:0006915; GO:0005737; GO:0046855; GO:0051717; GO:0008289; GO:0000287; GO:0030336; GO:0008285; GO:0051895; GO:0051898; GO:0046856; GO:0016314; GO:0051800; GO:0004438; GO:0043491; GO:0004722; GO:0004725; GO:0008138; GO:0010975; GO:0031647 "PDZ domain binding; PML body; apoptotic process; cytoplasm; inositol phosphate dephosphorylation; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; lipid binding; magnesium ion binding; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of focal adhesion assembly; negative regulation of protein kinase B signaling cascade; phosphatidylinositol dephosphorylation; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphatase activity; protein kinase B signaling cascade; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; regulation of neuron projection development; regulation of protein stability" IPR017361; IPR000008; IPR000340; IPR014019; IPR014020; IPR016130; "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)" pten Xenopus laevis (African clawed frog) TR6611_c0_g1_i1 Q9BXJ4 C1QT3_HUMAN 2.00E-07 GO:0035356; GO:0005581; GO:0005615; GO:0045444; GO:0042593; GO:0042347; GO:0010629; GO:0045721; GO:0050728; GO:1900165; GO:0071638; GO:0070374; GO:0070165; GO:0050715; GO:0051897; GO:0070206 cellular triglyceride homeostasis; collagen; extracellular space; fat cell differentiation; glucose homeostasis; negative regulation of NF-kappaB import into nucleus; negative regulation of gene expression; negative regulation of gluconeogenesis; negative regulation of inflammatory response; negative regulation of interleukin-6 secretion; negative regulation of monocyte chemotactic protein-1 production; positive regulation of ERK1 and ERK2 cascade; positive regulation of adiponectin secretion; positive regulation of cytokine secretion; positive regulation of protein kinase B signaling cascade; protein trimerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) TR6618_c0_g1_i1 Q86WJ1 CHD1L_HUMAN 4.00E-10 GO:0005524; GO:0004003; GO:0003677; GO:0006281; GO:0006338; GO:0005737; GO:0000166; GO:0005634; GO:0005886 ATP binding; ATP-dependent DNA helicase activity; DNA binding; DNA repair; chromatin remodeling; cytoplasm; nucleotide binding; nucleus; plasma membrane IPR002464; IPR014001; IPR001650; IPR002589; IPR027417; IPR000330; Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.12) (Amplified in liver cancer protein 1) CHD1L ALC1 Homo sapiens (Human) TR662_c0_g1_i1 B3EX21 ATPO_SORAR 1.00E-67 GO:0015986; GO:0005753; GO:0046933 "ATP synthesis coupled proton transport; mitochondrial proton-transporting ATP synthase complex; proton-transporting ATP synthase activity, rotational mechanism" IPR000711; IPR020781; IPR026015; "ATP synthase subunit O, mitochondrial (Oligomycin sensitivity conferral protein) (OSCP)" ATP5O Sorex araneus (Eurasian common shrew) (European shrew) TR6633_c1_g1_i1 Q4R7D9 PSA7L_MACFA 2.00E-41 GO:0005737; GO:0005634; GO:0019773; GO:1990111; GO:0004298; GO:0006511 "cytoplasm; nucleus; proteasome core complex, alpha-subunit complex; spermatoproteasome complex; threonine-type endopeptidase activity; ubiquitin-dependent protein catabolic process" IPR000426; IPR023332; IPR001353; Proteasome subunit alpha type-7-like (EC 3.4.25.1) PSMA7L QtsA-15547 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR6642_c0_g2_i1 Q96BD0 SO4A1_HUMAN 8.00E-26 GO:0016021; GO:0005886; GO:0043252; GO:0055085; GO:0005215 integral to membrane; plasma membrane; sodium-independent organic anion transport; transmembrane transport; transporter activity IPR002350; IPR020846; IPR016196; IPR004156; Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) SLCO4A1 OATP1 OATP4A1 OATPE SLC21A12 Homo sapiens (Human) TR6646_c0_g1_i1 Q8IV61 GRP3_HUMAN 6.00E-27 GO:0000165; GO:0046582; GO:0005088; GO:0007265; GO:0005509; GO:0019992; GO:0005085; GO:0032045; GO:0005887; GO:0048471; GO:0004871; GO:0007264 MAPK cascade; Rap GTPase activator activity; Ras guanyl-nucleotide exchange factor activity; Ras protein signal transduction; calcium ion binding; diacylglycerol binding; guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor complex; integral to plasma membrane; perinuclear region of cytoplasm; signal transducer activity; small GTPase mediated signal transduction IPR020454; IPR011992; IPR018247; IPR002048; IPR002219; IPR000651; IPR008937; IPR023578; IPR001895; Ras guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1) RASGRP3 GRP3 KIAA0846 Homo sapiens (Human) TR6649_c0_g1_i1 O46160 RL14_LUMRU 5.00E-55 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR014722; IPR002784; IPR008991; 60S ribosomal protein L14 RPL14 Lumbricus rubellus (Humus earthworm) TR6651_c0_g1_i1 Q2HJG2 PUF60_BOVIN 1.00E-23 GO:0003677; GO:0003723; GO:0008380; GO:0006915; GO:0006397; GO:0000166; GO:0005634; GO:0006355; GO:0030529; GO:0006351 "DNA binding; RNA binding; RNA splicing; apoptotic process; mRNA processing; nucleotide binding; nucleus; regulation of transcription, DNA-dependent; ribonucleoprotein complex; transcription, DNA-dependent" IPR012677; IPR006532; IPR000504; IPR003954; Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) PUF60 Bos taurus (Bovine) TR6653_c0_g1_i1 O97394 SDK_DROME 7.00E-60 GO:0007155; GO:0042675; GO:0005887; GO:0046533; GO:0050931 cell adhesion; compound eye cone cell differentiation; integral to plasma membrane; negative regulation of photoreceptor cell differentiation; pigment cell differentiation IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Protein sidekick sdk CG5227 Drosophila melanogaster (Fruit fly) TR6658_c0_g1_i1 Q9N2W7 NDUAC_CAEEL 2.00E-32 GO:0008137; GO:0009055; GO:0005743; GO:0005739; GO:0070469 NADH dehydrogenase (ubiquinone) activity; electron carrier activity; mitochondrial inner membrane; mitochondrion; respiratory chain IPR007763; Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (NADH-ubiquinone oxidoreductase 17.0 kDa subunit) Y94H6A.8 Caenorhabditis elegans TR666_c0_g1_i1 P08994 H2B2_TETTS 3.00E-50 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR000558; Histone H2B.2 (H2B-2) HTB2 TTHERM_00283180 Tetrahymena thermophila (strain SB210) TR6669_c0_g1_i1 Q61555 FBN2_MOUSE 4.00E-06 GO:0060346; GO:0005509; GO:0030326; GO:0005201; GO:0001527; GO:0030501; GO:0045669; GO:0035583 bone trabecula formation; calcium ion binding; embryonic limb morphogenesis; extracellular matrix structural constituent; microfibril; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; sequestering of TGFbeta in extracellular matrix IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR011398; IPR009030; IPR017878; Fibrillin-2 Fbn2 Fbn-2 Mus musculus (Mouse) TR6681_c0_g1_i1 Q69Z23 DYH17_MOUSE 4.00E-31 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 17, axonemal (Axonemal beta dynein heavy chain 17) (Ciliary dynein heavy chain 17)" Dnah17 Dnahc17 Kiaa3028 Mus musculus (Mouse) TR6694_c1_g1_i1 Q9Z131 3BP5_MOUSE 1.00E-15 GO:0017124; GO:0005737; GO:0035556; GO:0005739; GO:0004860 SH3 domain binding; cytoplasm; intracellular signal transduction; mitochondrion; protein kinase inhibitor activity IPR007940; SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) Sh3bp5 Sab Mus musculus (Mouse) TR6699_c0_g1_i1 P91929 NDUAA_DROME 4.00E-11 GO:0005524; GO:0005811; GO:0005759; GO:0005739; GO:0006139; GO:0055114; GO:0016773; GO:0070469 "ATP binding; lipid particle; mitochondrial matrix; mitochondrion; nucleobase-containing compound metabolic process; oxidation-reduction process; phosphotransferase activity, alcohol group as acceptor; respiratory chain" IPR002624; IPR015828; IPR027417; "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (Complex I-42kD) (CI-42kD) (NADH-ubiquinone oxidoreductase 42 kDa subunit)" ND42 CG6343 Drosophila melanogaster (Fruit fly) TR6709_c0_g1_i1 Q9H0M4 ZCPW1_HUMAN 5.00E-13 GO:0008270 zinc ion binding IPR000313; IPR011124; Zinc finger CW-type PWWP domain protein 1 ZCWPW1 Homo sapiens (Human) TR6744_c0_g1_i1 Q96MM6 HS12B_HUMAN 2.00E-06 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR6747_c1_g1_i1 P51570 GALK1_HUMAN 2.00E-10 GO:0005524; GO:0005829; GO:0019402; GO:0004335; GO:0005534; GO:0019388; GO:0044281 ATP binding; cytosol; galactitol metabolic process; galactokinase activity; galactose binding; galactose catabolic process; small molecule metabolic process IPR000705; IPR019741; IPR019539; IPR013750; IPR006204; IPR006203; IPR006206; IPR020568; IPR014721; Carbohydrate metabolism; galactose metabolism. Galactokinase (EC 2.7.1.6) (Galactose kinase) GALK1 GALK Homo sapiens (Human) TR6748_c1_g1_i1 A1A5B6 TBC25_MOUSE 2.00E-29 GO:0005097; GO:0005776; GO:0006914; GO:0031410; GO:1901096 Rab GTPase activator activity; autophagic vacuole; autophagy; cytoplasmic vesicle; regulation of autophagic vacuole maturation IPR000195; TBC1 domain family member 25 Tbc1d25 Mus musculus (Mouse) TR6748_c2_g1_i1 Q8BPQ7 SGSM1_MOUSE 2.00E-10 GO:0005794; GO:0005097; GO:0032851 Golgi apparatus; Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; IPR004012; Small G protein signaling modulator 1 (RUN and TBC1 domain-containing protein 2) Sgsm1 Rutbc2 Mus musculus (Mouse) TR6750_c0_g1_i1 Q9NBX4 RTXE_DROME 1.00E-07 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) TR6758_c1_g1_i1 Q9JJN2 ZFHX4_MOUSE 2.00E-19 GO:0005634; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR017970; IPR001356; IPR009057; IPR007087; IPR015880; IPR013087; IPR003604; Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) Zfhx4 Zfh4 Mus musculus (Mouse) TR6763_c0_g1_i1 Q84ME1 LUL3_ARATH 3.00E-07 GO:0004842; GO:0008270 ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; Protein modification; protein ubiquitination. Probable E3 ubiquitin-protein ligase LUL3 (EC 6.3.2.-) (Protein LOG2-LIKE UBIQUITIN LIGASE 3) (RING finger protein 398) LUL3 RF398 At5g19080 T16G12.120 Arabidopsis thaliana (Mouse-ear cress) TR6772_c0_g1_i1 Q80YS9 SGK71_MOUSE 2.00E-30 GO:0005524; GO:0004672 ATP binding; protein kinase activity IPR011989; IPR016024; IPR011009; IPR000719; Probable inactive protein kinase-like protein SgK071 homolog (Sugen kinase 071) Sgk071 Gm711 Mus musculus (Mouse) TR6774_c0_g1_i1 Q60847 COCA1_MOUSE 9.00E-10 GO:0007155; GO:0005581; GO:0005615; GO:0070062 cell adhesion; collagen; extracellular space; extracellular vesicular exosome IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain Col12a1 Mus musculus (Mouse) TR6779_c1_g1_i1 Q94887 NRX4_DROME 4.00E-09 GO:0008366; GO:0061343; GO:0007391; GO:0060857; GO:0007163; GO:0003015; GO:0005887; GO:0021682; GO:0005919; GO:0048786; GO:0097105; GO:0008104; GO:0035151; GO:0019991; GO:0008039; GO:0016081; GO:0016080; GO:0072553 "axon ensheathment; cell adhesion involved in heart morphogenesis; dorsal closure; establishment of glial blood-brain barrier; establishment or maintenance of cell polarity; heart process; integral to plasma membrane; nerve maturation; pleated septate junction; presynaptic active zone; presynaptic membrane assembly; protein localization; regulation of tube size, open tracheal system; septate junction assembly; synaptic target recognition; synaptic vesicle docking involved in exocytosis; synaptic vesicle targeting; terminal button organization" IPR000421; IPR008985; IPR013320; IPR000742; IPR008979; IPR001791; IPR003585; Neurexin-4 (Neurexin IV) Nrx-IV Nrx CG6827 Drosophila melanogaster (Fruit fly) TR680_c0_g1_i1 Q96RY7 IF140_HUMAN 3.00E-12 GO:0042384; GO:0035085; GO:0036064; GO:0030991; GO:0032391 cilium assembly; cilium axoneme; cilium basal body; intraflagellar transport particle A; photoreceptor connecting cilium IPR015943; IPR001680; IPR017986; Intraflagellar transport protein 140 homolog (WD and tetratricopeptide repeats protein 2) IFT140 KIAA0590 WDTC2 Homo sapiens (Human) TR6809_c0_g1_i1 P18503 CAS4_EPHMU 2.00E-06 GO:0005581 collagen IPR008160; Short-chain collagen C4 (Fragment) Ephydatia muelleri (Mueller's freshwater sponge) TR681_c0_g1_i1 Q8N0N3 BGBP_PENMO 3.00E-24 GO:0001872; GO:0005975; GO:0005576; GO:0004553; GO:0045087 "(1->3)-beta-D-glucan binding; carbohydrate metabolic process; extracellular region; hydrolase activity, hydrolyzing O-glycosyl compounds; innate immune response" IPR008985; IPR013320; IPR000757; "Beta-1,3-glucan-binding protein (GBP)" Penaeus monodon (Giant tiger prawn) TR6816_c0_g1_i1 Q8NE62 CHDH_HUMAN 3.00E-25 GO:0008812; GO:0050660; GO:0019285; GO:0005743 choline dehydrogenase activity; flavin adenine dinucleotide binding; glycine betaine biosynthetic process from choline; mitochondrial inner membrane IPR012132; IPR000172; IPR007867; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. "Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)" CHDH Homo sapiens (Human) TR6821_c0_g1_i1 Q08CS6 MOXD2_DANRE 3.00E-10 GO:0006584; GO:0005507; GO:0004500; GO:0016021 catecholamine metabolic process; copper ion binding; dopamine beta-monooxygenase activity; integral to membrane IPR014784; IPR000323; IPR000945; IPR005018; IPR008977; DBH-like monooxygenase protein 2 homolog (EC 1.14.17.-) moxd2 moxd1l si:ch211-203k16.5 Danio rerio (Zebrafish) (Brachydanio rerio) TR6835_c0_g1_i1 P58059 RT21_MOUSE 2.00E-24 GO:0005743; GO:0005840; GO:0003735; GO:0006412 mitochondrial inner membrane; ribosome; structural constituent of ribosome; translation IPR001911; "28S ribosomal protein S21, mitochondrial (MRP-S21) (S21mt)" Mrps21 Rpms21 Mus musculus (Mouse) TR6837_c0_g1_i1 O93430 GLRA1_DANRE 6.00E-16 GO:0030054; GO:0034707; GO:0016934; GO:0016594; GO:0005887; GO:0045211; GO:0022824 cell junction; chloride channel complex; extracellular-glycine-gated chloride channel activity; glycine binding; integral to plasma membrane; postsynaptic membrane; transmitter-gated ion channel activity IPR006028; IPR008127; IPR008128; IPR006202; IPR006201; IPR006029; IPR018000; Glycine receptor subunit alphaZ1 glra1 Danio rerio (Zebrafish) (Brachydanio rerio) TR6838_c0_g1_i1 P70080 TPH1_CHICK 1.00E-32 GO:0016597; GO:0009072; GO:0046849; GO:0005506; GO:0060749; GO:0042427; GO:0004510 amino acid binding; aromatic amino acid family metabolic process; bone remodeling; iron ion binding; mammary gland alveolus development; serotonin biosynthetic process; tryptophan 5-monooxygenase activity IPR002912; IPR001273; IPR018301; IPR019774; IPR005963; IPR019773; Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2. Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1) TPH1 TPH Gallus gallus (Chicken) TR6846_c0_g1_i1 Q96RW7 HMCN1_HUMAN 4.00E-08 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR6846_c0_g2_i1 O08747 UNC5C_MOUSE 5.00E-07 GO:0033564; GO:0006915; GO:0007420; GO:0016021; GO:0005042; GO:0005886; GO:0043065; GO:0030334 anterior/posterior axon guidance; apoptotic process; brain development; integral to membrane; netrin receptor activity; plasma membrane; positive regulation of apoptotic process; regulation of cell migration IPR011029; IPR000488; IPR007110; IPR013783; IPR013098; IPR003598; IPR000884; IPR000906; Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C) (Rostral cerebellar malformation protein) Unc5c Rcm Unc5h3 Mus musculus (Mouse) TR6848_c0_g1_i2 Q4V8V2 NUD17_DANRE 4.00E-67 GO:0016787; GO:0046872 hydrolase activity; metal ion binding IPR000086; IPR015797; Nucleoside diphosphate-linked moiety X motif 17 (Nudix motif 17) (EC 3.6.1.-) nudt17 zgc:114128 Danio rerio (Zebrafish) (Brachydanio rerio) TR6866_c0_g1_i1 Q03567 YLD2_CAEEL 2.00E-26 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR011701; IPR020846; IPR016196; Uncharacterized transporter C38C10.2 C38C10.2 Caenorhabditis elegans TR6877_c0_g1_i1 A6P3B2 FMRF_MUSDO 1.00E-08 GO:0005576; GO:0007218 extracellular region; neuropeptide signaling pathway IPR002544; FMRFamide neuropeptides [Cleaved into: MudFMRFamide-2; MudFMRFamide-3; MudFMRFamide-4; MudFMRFamide-5; MudFMRFamide-6; MudFMRFamide-7; MudFMRFamide-8 (MudFMRFamide-10); MudFMRFamide-9 (MudFMRFamide-11) (MudFMRFamide-12) (MudFMRFamide-13); MudFMRFamide-14; MudFMRFamide-15; MudFMRFamide-17; MudFMRFamide-16; MudFMRFamide-18] fmrf Musca domestica (House fly) TR6879_c0_g1_i1 A1E2V0 BIRC3_CANFA 6.00E-16 GO:0006915; GO:0005737; GO:0070266; GO:0060546; GO:0042326; GO:2000378; GO:0005634; GO:0016567; GO:0042981; GO:0004842; GO:0008270 apoptotic process; cytoplasm; necroptosis; negative regulation of necroptosis; negative regulation of phosphorylation; negative regulation of reactive oxygen species metabolic process; nucleus; protein ubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) BIRC3 Canis familiaris (Dog) (Canis lupus familiaris) TR6879_c0_g1_i2 Q90660 BIR_CHICK 2.00E-15 GO:0006915; GO:0005737; GO:0043066; GO:0005634; GO:0008270 apoptotic process; cytoplasm; negative regulation of apoptotic process; nucleus; zinc ion binding IPR001370; IPR001315; IPR011029; IPR001841; Inhibitor of apoptosis protein (IAP) (Inhibitor of T-cell apoptosis protein) ITA IAP1 Gallus gallus (Chicken) TR688_c0_g1_i1 Q54QM8 RL26_DICDI 2.00E-47 GO:0015934; GO:0003735; GO:0006412 large ribosomal subunit; structural constituent of ribosome; translation IPR005824; IPR014722; IPR005825; IPR005756; IPR008991; 60S ribosomal protein L26 rpl26 DDB_G0283741 Dictyostelium discoideum (Slime mold) TR6883_c0_g1_i1 O73590 ZFHX4_CHICK 3.00E-14 GO:0005634; GO:0043565; GO:0003700; GO:0006351; GO:0008270 "nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; zinc ion binding" IPR017970; IPR001356; IPR009057; IPR007087; IPR015880; IPR013087; IPR003604; Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) (Zinc finger/apterous-related homeobox protein) ZFHX4 ZAX Gallus gallus (Chicken) TR6885_c0_g2_i1 Q25381 ACTM_LYTPI 1.00E-18 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; "Actin, muscle (LPM) (Fragment)" Lytechinus pictus (Painted sea urchin) TR6894_c2_g1_i1 Q96RW7 HMCN1_HUMAN 1.00E-28 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR6896_c0_g1_i1 Q96AY4 TTC28_HUMAN 4.00E-16 GO:0051301; GO:0005737; GO:0005815; GO:0030496; GO:0007067; GO:0000922 cell division; cytoplasm; microtubule organizing center; midbody; mitosis; spindle pole IPR024983; IPR013026; IPR011990; IPR001440; IPR013105; IPR019734; Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) TTC28 KIAA1043 TPRBK Homo sapiens (Human) TR6912_c0_g1_i1 O08852 PKD1_MOUSE 2.00E-11 GO:0007259; GO:0016323; GO:0048754; GO:0005262; GO:0030246; GO:0001502; GO:0007050; GO:0005737; GO:0042994; GO:0050982; GO:0048565; GO:0001892; GO:0048806; GO:0007507; GO:0016021; GO:0001822; GO:0001889; GO:0060428; GO:0072177; GO:0072218; GO:0072205; GO:0072287; GO:0072237; GO:0031512; GO:0021915; GO:0007218; GO:0006807; GO:0005634; GO:0018105; GO:0060674; GO:0005886; GO:0002133; GO:0031659; GO:0032092; GO:0045944; GO:0006611; GO:0060236; GO:0043588; GO:0021510 JAK-STAT cascade; basolateral plasma membrane; branching morphogenesis of an epithelial tube; calcium channel activity; carbohydrate binding; cartilage condensation; cell cycle arrest; cytoplasm; cytoplasmic sequestering of transcription factor; detection of mechanical stimulus; digestive tract development; embryonic placenta development; genitalia development; heart development; integral to membrane; kidney development; liver development; lung epithelium development; mesonephric duct development; metanephric ascending thin limb development; metanephric collecting duct development; metanephric distal tubule morphogenesis; metanephric proximal tubule development; motile primary cilium; neural tube development; neuropeptide signaling pathway; nitrogen compound metabolic process; nucleus; peptidyl-serine phosphorylation; placenta blood vessel development; plasma membrane; polycystin complex; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of protein binding; positive regulation of transcription from RNA polymerase II promoter; protein export from nucleus; regulation of mitotic spindle organization; skin development; spinal cord development IPR001304; IPR016186; IPR016187; IPR000483; IPR000203; IPR001611; IPR003591; IPR008976; IPR000372; IPR022409; IPR002859; IPR013122; IPR000434; IPR000601; IPR001024; IPR006228; IPR014010; IPR002889; IPR013994; Polycystin-1 (Autosomal dominant polycystic kidney disease 1 protein homolog) Pkd1 Mus musculus (Mouse) TR6912_c0_g2_i1 O08852 PKD1_MOUSE 1.00E-09 GO:0007259; GO:0016323; GO:0048754; GO:0005262; GO:0030246; GO:0001502; GO:0007050; GO:0005737; GO:0042994; GO:0050982; GO:0048565; GO:0001892; GO:0048806; GO:0007507; GO:0016021; GO:0001822; GO:0001889; GO:0060428; GO:0072177; GO:0072218; GO:0072205; GO:0072287; GO:0072237; GO:0031512; GO:0021915; GO:0007218; GO:0006807; GO:0005634; GO:0018105; GO:0060674; GO:0005886; GO:0002133; GO:0031659; GO:0032092; GO:0045944; GO:0006611; GO:0060236; GO:0043588; GO:0021510 JAK-STAT cascade; basolateral plasma membrane; branching morphogenesis of an epithelial tube; calcium channel activity; carbohydrate binding; cartilage condensation; cell cycle arrest; cytoplasm; cytoplasmic sequestering of transcription factor; detection of mechanical stimulus; digestive tract development; embryonic placenta development; genitalia development; heart development; integral to membrane; kidney development; liver development; lung epithelium development; mesonephric duct development; metanephric ascending thin limb development; metanephric collecting duct development; metanephric distal tubule morphogenesis; metanephric proximal tubule development; motile primary cilium; neural tube development; neuropeptide signaling pathway; nitrogen compound metabolic process; nucleus; peptidyl-serine phosphorylation; placenta blood vessel development; plasma membrane; polycystin complex; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; positive regulation of protein binding; positive regulation of transcription from RNA polymerase II promoter; protein export from nucleus; regulation of mitotic spindle organization; skin development; spinal cord development IPR001304; IPR016186; IPR016187; IPR000483; IPR000203; IPR001611; IPR003591; IPR008976; IPR000372; IPR022409; IPR002859; IPR013122; IPR000434; IPR000601; IPR001024; IPR006228; IPR014010; IPR002889; IPR013994; Polycystin-1 (Autosomal dominant polycystic kidney disease 1 protein homolog) Pkd1 Mus musculus (Mouse) TR6922_c0_g1_i1 Q9UMY4 SNX12_HUMAN 3.00E-14 GO:0007154; GO:0016020; GO:0035091; GO:0015031 P16333 cell communication; membrane; phosphatidylinositol binding; protein transport IPR001683; Sorting nexin-12 SNX12 Homo sapiens (Human) TR6933_c0_g1_i1 F7H9X2 TRIM2_CALJA 1.00E-15 GO:0005737; GO:0043523; GO:0004842; GO:0008270 cytoplasm; regulation of neuron apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR011042; IPR003649; IPR001298; IPR017868; IPR013783; IPR014756; IPR001258; IPR013017; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Callithrix jacchus (White-tufted-ear marmoset) TR6938_c1_g1_i1 P09487 PPBT_BOVIN 4.00E-29 GO:0004035; GO:0031225; GO:0046872; GO:0005886; GO:0033280 alkaline phosphatase activity; anchored to membrane; metal ion binding; plasma membrane; response to vitamin D IPR017849; IPR001952; IPR018299; IPR017850; "Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)" ALPL Bos taurus (Bovine) TR6947_c1_g1_i1 P82251 BAT1_HUMAN 7.00E-45 GO:0015184; GO:0007596; GO:0006520; GO:0005887; GO:0050900; GO:0015175; GO:0042605; GO:0006461 L-cystine transmembrane transporter activity; blood coagulation; cellular amino acid metabolic process; integral to plasma membrane; leukocyte migration; neutral amino acid transmembrane transporter activity; peptide antigen binding; protein complex assembly IPR002293; "B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)" SLC7A9 BAT1 Homo sapiens (Human) TR6954_c0_g1_i1 P61917 NPC2_PANTR 1.00E-06 GO:0015485; GO:0033344; GO:0042632; GO:0008203; GO:0005783; GO:0005576; GO:0032367; GO:0005764; GO:0009615 cholesterol binding; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; endoplasmic reticulum; extracellular region; intracellular cholesterol transport; lysosome; response to virus IPR014756; IPR003172; Epididymal secretory protein E1 (EPI-1) (Niemann Pick type C2 protein homolog) NPC2 Pan troglodytes (Chimpanzee) TR6956_c0_g1_i1 Q5ZJX5 K1609_CHICK 4.00E-08 IPR006571; TLD domain-containing protein 1 (TBC/LysM-associated domain-containing protein 1) TLDC1 RCJMB04_14k7 Gallus gallus (Chicken) TR6963_c1_g1_i1 Q5G271 NETR_PANTR 4.00E-06 GO:0030424; GO:0031410; GO:0030425; GO:0006887; GO:0005576; GO:0005886; GO:0006508; GO:0005044; GO:0004252; GO:0043083; GO:0043195; GO:0031638 axon; cytoplasmic vesicle; dendrite; exocytosis; extracellular region; plasma membrane; proteolysis; scavenger receptor activity; serine-type endopeptidase activity; synaptic cleft; terminal bouton; zymogen activation IPR000001; IPR013806; IPR018056; IPR001254; IPR018114; IPR001314; IPR001190; IPR017448; IPR009003; Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Pan troglodytes (Chimpanzee) TR697_c0_g1_i1 Q5BKL8 XIAP_XENTR 7.00E-18 GO:0016055; GO:0043027; GO:0005737; GO:0016874; GO:0007275; GO:0043066; GO:0045861; GO:0008270 Wnt receptor signaling pathway; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytoplasm; ligase activity; multicellular organismal development; negative regulation of apoptotic process; negative regulation of proteolysis; zinc ion binding IPR001370; IPR001841; E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (X-linked inhibitor of apoptosis protein) (X-linked IAP) xiap birc4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR697_c0_g2_i1 Q13075 BIRC1_HUMAN 1.00E-18 GO:0005524; GO:0016323; GO:0004869; GO:0005737; GO:0006954; GO:0045087; GO:0046872; GO:0043154; GO:0043524; GO:0007399; GO:0017111 ATP binding; basolateral plasma membrane; cysteine-type endopeptidase inhibitor activity; cytoplasm; inflammatory response; innate immune response; metal ion binding; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of neuron apoptotic process; nervous system development; nucleoside-triphosphatase activity IPR003593; IPR001370; IPR007111; IPR027417; Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein) NAIP BIRC1 Homo sapiens (Human) TR6976_c0_g1_i1 Q9BQ67 GRWD1_HUMAN 5.00E-25 GO:0005737; GO:0005730 cytoplasm; nucleolus IPR020472; IPR022052; IPR015943; IPR001680; IPR019775; IPR017986; Glutamate-rich WD repeat-containing protein 1 GRWD1 GRWD KIAA1942 WDR28 Homo sapiens (Human) TR6995_c0_g1_i1 Q9HCB6 SPON1_HUMAN 4.00E-07 GO:0007155; GO:0005615; GO:0005578 P05067-4 cell adhesion; extracellular space; proteinaceous extracellular matrix IPR002861; IPR009465; IPR000884; Spondin-1 (F-spondin) (Vascular smooth muscle cell growth-promoting factor) SPON1 KIAA0762 VSGP Homo sapiens (Human) TR7_c0_g1_i1 Q8VHI5 VITRN_MOUSE 4.00E-07 GO:0030198; GO:0005539; GO:0005614; GO:0010811 extracellular matrix organization; glycosaminoglycan binding; interstitial matrix; positive regulation of cell-substrate adhesion IPR004043; IPR002035; Vitrin Vit Mus musculus (Mouse) TR7013_c0_g1_i1 P24014 SLIT_DROME 2.00E-15 GO:0035385; GO:0071666; GO:0016199; GO:0005509; GO:0048813; GO:0007502; GO:0035050; GO:0007427; GO:0008347; GO:0008406; GO:0008201; GO:0050929; GO:0046331; GO:0008078; GO:0001764; GO:0003151; GO:0005886; GO:0022409; GO:0005578; GO:2000274; GO:0007432 "Roundabout signaling pathway; Slit-Robo signaling complex; axon midline choice point recognition; calcium ion binding; dendrite morphogenesis; digestive tract mesoderm development; embryonic heart tube development; epithelial cell migration, open tracheal system; glial cell migration; gonad development; heparin binding; induction of negative chemotaxis; lateral inhibition; mesodermal cell migration; neuron migration; outflow tract morphogenesis; plasma membrane; positive regulation of cell-cell adhesion; proteinaceous extracellular matrix; regulation of epithelial cell migration, open tracheal system; salivary gland boundary specification" IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; IPR026906; Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) TR7025_c0_g1_i1 Q9P2E3 ZNFX1_HUMAN 1.00E-11 GO:0046872 metal ion binding IPR016024; IPR027417; NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) TR7027_c1_g1_i1 P10076 ZFP26_MOUSE 1.00E-10 GO:0003677; GO:0046872; GO:0005634; GO:0006355 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 26 (Zfp-26) (Protein mKR3) Zfp26 Kiaa4196 Mkr3 Zfp-26 Mus musculus (Mouse) TR7033_c0_g1_i1 Q8CAS9 PARP9_MOUSE 2.00E-08 GO:0003950; GO:0005737; GO:0005829; GO:0006302; GO:0005634; GO:0060330 NAD+ ADP-ribosyltransferase activity; cytoplasm; cytosol; double-strand break repair; nucleus; regulation of response to interferon-gamma IPR002589; IPR012317; Poly [ADP-ribose] polymerase 9 (PARP-9) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 9) (ARTD9) (B aggressive lymphoma protein homolog) Parp9 Bal Mus musculus (Mouse) TR7062_c0_g1_i1 P20397 NUCL_XENLA 1.00E-06 GO:0003677; GO:0003723; GO:0005730; GO:0000166 DNA binding; RNA binding; nucleolus; nucleotide binding IPR012677; IPR000504; Nucleolin (Protein C23) ncl Xenopus laevis (African clawed frog) TR7064_c0_g1_i1 Q336X9 MPK6_ORYSJ 4.00E-09 GO:0005524; GO:0004707; GO:0000165 ATP binding; MAP kinase activity; MAPK cascade IPR011009; IPR003527; IPR000719; IPR017441; IPR002290; IPR008271; Mitogen-activated protein kinase 6 (MAP kinase 6) (EC 2.7.11.24) MPK6 Os10g0533600 LOC_Os10g38950 OSJNBa0053C23.4 Oryza sativa subsp. japonica (Rice) TR7064_c0_g2_i1 Q9QZ05 E2AK4_MOUSE 4.00E-39 GO:0005524; GO:0009267; GO:0022626; GO:0030968; GO:0004694; GO:0017148; GO:0043558 ATP binding; cellular response to starvation; cytosolic ribosome; endoplasmic reticulum unfolded protein response; eukaryotic translation initiation factor 2alpha kinase activity; negative regulation of translation; regulation of translational initiation in response to stress IPR004154; IPR024435; IPR011009; IPR000719; IPR017441; IPR006575; IPR008271; IPR016255; IPR016135; Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2) Eif2ak4 Gcn2 Kiaa1338 Mus musculus (Mouse) TR7066_c0_g1_i1 P24797 AT1A2_CHICK 2.00E-72 GO:0005524; GO:0006754; GO:0005737; GO:0016021; GO:0046872; GO:0001504; GO:0005886; GO:0006942; GO:0005391 ATP binding; ATP biosynthetic process; cytoplasm; integral to membrane; metal ion binding; neurotransmitter uptake; plasma membrane; regulation of striated muscle contraction; sodium:potassium-exchanging ATPase activity IPR006068; IPR004014; IPR023299; IPR005775; IPR018303; IPR023298; IPR008250; IPR001757; IPR023214; Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) ATP1A2 Gallus gallus (Chicken) TR7066_c1_g1_i1 Q6RWA9 AT1A_TAESO 7.00E-36 GO:0005524; GO:0006754; GO:0016021; GO:0046872; GO:0005391 ATP binding; ATP biosynthetic process; integral to membrane; metal ion binding; sodium:potassium-exchanging ATPase activity IPR006068; IPR004014; IPR023299; IPR005775; IPR018303; IPR023298; IPR008250; IPR001757; IPR023214; Sodium/potassium-transporting ATPase subunit alpha (Na(+)/K(+) ATPase alpha subunit) (EC 3.6.3.9) (Sodium pump subunit alpha) (TNaK1-alpha) Taenia solium (Pork tapeworm) TR7076_c0_g1_i1 P68264 ACTS_OREMO 3.00E-27 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin, alpha skeletal muscle (Alpha-actin-1)" acta1 Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica) TR7088_c0_g1_i1 A0A1F4 EYS_DROME 1.00E-10 GO:0005509; GO:0000902; GO:0005201; GO:0005615; GO:0016021; GO:0005886; GO:0042052; GO:0010378 calcium ion binding; cell morphogenesis; extracellular matrix structural constituent; extracellular space; integral to membrane; plasma membrane; rhabdomere development; temperature compensation of the circadian clock IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR001791; Protein eyes shut (Protein spacemaker) eys spam CG33955 Drosophila melanogaster (Fruit fly) TR7088_c1_g1_i1 P13944 COCA1_CHICK 9.00E-08 GO:0007155; GO:0005581 cell adhesion; collagen IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain (Fibrochimerin) COL12A1 Gallus gallus (Chicken) TR7089_c0_g1_i1 Q8INF0 GCY8E_DROME 1.00E-20 GO:0005525; GO:0006184; GO:0070025; GO:0004383; GO:0008074; GO:0020037; GO:0035556; GO:0046872; GO:0070026; GO:0019826; GO:0001666; GO:0000302 "GTP binding; GTP catabolic process; carbon monoxide binding; guanylate cyclase activity; guanylate cyclase complex, soluble; heme binding; intracellular signal transduction; metal ion binding; nitric oxide binding; oxygen sensor activity; response to hypoxia; response to reactive oxygen species" IPR001054; IPR018297; IPR011645; IPR011644; IPR024096; Soluble guanylate cyclase 88E (EC 4.6.1.2) Gyc88E CG4154 Drosophila melanogaster (Fruit fly) TR7091_c0_g1_i1 Q55E58 PATS1_DICDI 3.00E-07 GO:0005524; GO:0005525; GO:0042641; GO:0000281; GO:0004721; GO:0006470; GO:0004674; GO:0007264 ATP binding; GTP binding; actomyosin; mitotic cytokinesis; phosphoprotein phosphatase activity; protein dephosphorylation; protein serine/threonine kinase activity; small GTPase mediated signal transduction IPR011009; IPR001611; IPR013684; IPR010569; IPR017906; IPR027417; IPR000719; IPR011047; IPR020859; IPR001245; IPR008271; IPR005225; IPR001806; IPR015943; IPR001680; IPR017986; Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) TR7095_c0_g1_i1 O96790 DPGN_DIPMA 2.00E-07 GO:0005576; GO:0050819; GO:0004867 extracellular region; negative regulation of coagulation; serine-type endopeptidase inhibitor activity IPR002350; Serine protease inhibitor dipetalogastin (Dipetalin) (Fragment) Dipetalogaster maximus (Blood-sucking bug) TR7100_c0_g2_i1 Q9Y4A5 TRRAP_HUMAN 9.00E-68 GO:0035267; GO:0000125; GO:0030914; GO:0043968; GO:0043967; GO:0016578; GO:0007093; GO:0016773; GO:0006355; GO:0003713; GO:0003712; GO:0033276; GO:0006351 O15265; P38398; P11474; P01106 "NuA4 histone acetyltransferase complex; PCAF complex; STAGA complex; histone H2A acetylation; histone H4 acetylation; histone deubiquitination; mitotic cell cycle checkpoint; phosphotransferase activity, alcohol group as acceptor; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription cofactor activity; transcription factor TFTC complex; transcription, DNA-dependent" IPR011989; IPR016024; IPR003152; IPR011009; IPR000403; IPR003151; IPR014009; IPR011990; Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) TRRAP PAF400 Homo sapiens (Human) TR7105_c0_g1_i1 P77735 YAJO_ECOLI 3.00E-23 GO:0016491; GO:0006772 oxidoreductase activity; thiamine metabolic process IPR001395; IPR020471; IPR023210; Uncharacterized oxidoreductase YajO (EC 1.-.-.-) yajO b0419 JW0409 Escherichia coli (strain K12) TR711_c0_g1_i1 Q4JIJ3 METH_BOVIN 5.00E-72 GO:0031419; GO:0005737; GO:0008898; GO:0008705; GO:0042558; GO:0008270 cobalamin binding; cytoplasm; homocysteine S-methyltransferase activity; methionine synthase activity; pteridine-containing compound metabolic process; zinc ion binding IPR003759; IPR006158; IPR011005; IPR011822; IPR000489; IPR003726; IPR004223; Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1. Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Vitamin-B12 dependent methionine synthase) (MS) MTR Bos taurus (Bovine) TR7122_c0_g1_i1 P10394 POL4_DROME 4.00E-15 GO:0015074; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 DNA integration; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR000477; Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) TR7128_c0_g1_i1 Q0MQA3 NDUA6_PONPY 1.00E-38 GO:0005743; GO:0055114; GO:0070469 mitochondrial inner membrane; oxidation-reduction process; respiratory chain IPR008011; IPR016488; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (Complex I-B14) (CI-B14) (NADH-ubiquinone oxidoreductase B14 subunit) NDUFA6 Pongo pygmaeus (Bornean orangutan) TR7129_c0_g2_i1 P25931 NPYR_DROME 1.00E-07 GO:0016021; GO:0004983; GO:0008188; GO:0005886 integral to membrane; neuropeptide Y receptor activity; neuropeptide receptor activity; plasma membrane IPR000276; IPR017452; IPR000611; Neuropeptide Y receptor (NPY-R) (PR4 receptor) NepYr CG5811 Drosophila melanogaster (Fruit fly) TR7136_c0_g1_i1 P04760 ACHG_MOUSE 7.00E-08 GO:0004889; GO:0005892; GO:0030054; GO:0045211; GO:0042391 acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; postsynaptic membrane; regulation of membrane potential IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Acetylcholine receptor subunit gamma Chrng Acrg Mus musculus (Mouse) TR7149_c0_g1_i1 G5E8K5 ANK3_MOUSE 6.00E-12 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR7161_c0_g1_i1 P35546 RET_MOUSE 8.00E-15 GO:0005524; GO:0000165; GO:0061146; GO:0005509; GO:0071300; GO:0001838; GO:0010008; GO:0048484; GO:0007156; GO:0005887; GO:0033619; GO:0001755; GO:0007158; GO:0042551; GO:0018108; GO:0033630; GO:0030335; GO:0045793; GO:2001241; GO:0072300; GO:0010976; GO:0045893; GO:0050770; GO:0048265; GO:0004714; GO:0007169; GO:0035799; GO:0001657 Q60629 "ATP binding; MAPK cascade; Peyer's patch morphogenesis; calcium ion binding; cellular response to retinoic acid; embryonic epithelial tube formation; endosome membrane; enteric nervous system development; homophilic cell adhesion; integral to plasma membrane; membrane protein proteolysis; neural crest cell migration; neuron cell-cell adhesion; neuron maturation; peptidyl-tyrosine phosphorylation; positive regulation of cell adhesion mediated by integrin; positive regulation of cell migration; positive regulation of cell size; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of metanephric glomerulus development; positive regulation of neuron projection development; positive regulation of transcription, DNA-dependent; regulation of axonogenesis; response to pain; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway; ureter maturation; ureteric bud development" IPR002126; IPR015919; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; IPR016249; Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] Ret Mus musculus (Mouse) TR7177_c1_g1_i1 Q658L1 F154B_HUMAN 3.00E-21 IPR024963; Protein FAM154B FAM154B Homo sapiens (Human) TR718_c0_g1_i1 P81287 ANXA5_BOVIN 1.00E-22 GO:0060090; GO:0007596; GO:0005509; GO:0005544; GO:0005622; GO:0050819 "binding, bridging; blood coagulation; calcium ion binding; calcium-dependent phospholipid binding; intracellular; negative regulation of coagulation" IPR001464; IPR018502; IPR018252; IPR015473; IPR002392; Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CBP-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) ANXA5 ANX5 Bos taurus (Bovine) TR7183_c0_g1_i1 Q63HN8 RN213_HUMAN 4.00E-10 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR018957; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) TR7202_c1_g1_i1 P51472 OPSB_ASTFA 1.00E-06 GO:0004930; GO:0016021; GO:0009881; GO:0007602; GO:0018298; GO:0007601 G-protein coupled receptor activity; integral to membrane; photoreceptor activity; phototransduction; protein-chromophore linkage; visual perception IPR000276; IPR017452; IPR001760; IPR001521; IPR027430; Blue-sensitive opsin (Blue cone photoreceptor pigment) B23 Astyanax fasciatus (Blind cave fish) (Astyanax mexicanus) TR7213_c1_g3_i2 Q3T0S0 TM128_BOVIN 7.00E-13 GO:0016021 integral to membrane Transmembrane protein 128 TMEM128 Bos taurus (Bovine) TR7217_c0_g1_i1 Q03601 NHL1_CAEEL 1.00E-07 GO:0008270 G5EFS1; O62482 zinc ion binding IPR011042; IPR001258; IPR013017; IPR018957; IPR001841; IPR013083; IPR017907; RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans TR7224_c0_g1_i1 P42700 RO60_XENLA 4.00E-28 GO:0003723; GO:0030030; GO:0005737; GO:0046872; GO:0030529 RNA binding; cell projection organization; cytoplasm; metal ion binding; ribonucleoprotein complex IPR008858; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) trove2 Xenopus laevis (African clawed frog) TR7228_c0_g1_i1 Q09910 YAJB_SCHPO 8.00E-07 GO:0005794; GO:0006882; GO:0005789; GO:0016021; GO:0046872 Golgi apparatus; cellular zinc ion homeostasis; endoplasmic reticulum membrane; integral to membrane; metal ion binding IPR004254; Uncharacterized protein C30D11.11 SPAC30D11.11 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR7240_c0_g1_i1 O14678 ABCD4_HUMAN 2.00E-48 GO:0005524; GO:0006200; GO:0043190; GO:0042626; GO:0009235; GO:0005789; GO:0016021; GO:0005778; GO:0005777 "ATP binding; ATP catabolic process; ATP-binding cassette (ABC) transporter complex; ATPase activity, coupled to transmembrane movement of substances; cobalamin metabolic process; endoplasmic reticulum membrane; integral to membrane; peroxisomal membrane; peroxisome" IPR003593; IPR011527; IPR010509; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family D member 4 (PMP70-related protein) (P70R) (Peroxisomal membrane protein 1-like) (PXMP1-L) (Peroxisomal membrane protein 69) (PMP69) ABCD4 PXMP1L Homo sapiens (Human) TR7250_c0_g1_i1 P49951 CLHC1_BOVIN 2.00E-38 GO:0030132; GO:0030130; GO:0006886; GO:0042470; GO:0030117; GO:0005739; GO:0005198; GO:0016192 Itself clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; intracellular protein transport; melanosome; membrane coat; mitochondrion; structural molecule activity; vesicle-mediated transport IPR016024; IPR000547; IPR016025; IPR015348; IPR001473; IPR022365; IPR016341; IPR011990; Clathrin heavy chain 1 CLTC Bos taurus (Bovine) TR7266_c0_g2_i1 Q8TEV9 SMCR8_HUMAN 3.00E-09 GO:0005634 nucleus IPR021713; Smith-Magenis syndrome chromosomal region candidate gene 8 protein SMCR8 Homo sapiens (Human) TR727_c0_g1_i1 Q5T7B8 KIF24_HUMAN 7.00E-43 GO:0005524; GO:0005814; GO:0042384; GO:0005871; GO:0005874; GO:0007019; GO:0003777; GO:0007018 O43303; Q8IW35 ATP binding; centriole; cilium assembly; kinesin complex; microtubule; microtubule depolymerization; microtubule motor activity; microtubule-based movement IPR027640; IPR019821; IPR001752; IPR027417; IPR001660; IPR013761; IPR021129; Kinesin-like protein KIF24 KIF24 C9orf48 Homo sapiens (Human) TR7272_c0_g1_i1 Q55CB7 RASY_DICDI 9.00E-08 GO:0005525; GO:0003924; GO:0007265; GO:0005886 GTP binding; GTPase activity; Ras protein signal transduction; plasma membrane IPR027417; IPR005225; IPR001806; IPR020849; Ras-like protein rasY rasY DDB_G0270126 Dictyostelium discoideum (Slime mold) TR7272_c0_g2_i1 P34213 RAB6A_CAEEL 9.00E-09 GO:0005525; GO:0031985; GO:0060473; GO:0060471; GO:0005886; GO:0015031; GO:0007264 GTP binding; Golgi cisterna; cortical granule; cortical granule exocytosis; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-6.1 rab-6.1 F59B2.7 Caenorhabditis elegans TR7276_c0_g1_i1 P21329 RTJK_DROFU 2.00E-06 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) TR7277_c0_g1_i1 Q96G42 KLD7B_HUMAN 4.00E-17 IPR015915; IPR006652; Kelch domain-containing protein 7B KLHDC7B Homo sapiens (Human) TR7281_c1_g1_i1 P84082 ARF2_RAT 3.00E-08 GO:0005525; GO:0005794; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi apparatus; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor 2 Arf2 Rattus norvegicus (Rat) TR7283_c0_g1_i1 P26779 SAP_BOVIN 5.00E-07 GO:0005794; GO:0071310; GO:0060742; GO:0005615; GO:0005764; GO:0005739; GO:0060736; GO:0043408; GO:0019216; GO:0006665 Golgi apparatus; cellular response to organic substance; epithelial cell differentiation involved in prostate gland development; extracellular space; lysosome; mitochondrion; prostate gland growth; regulation of MAPK cascade; regulation of lipid metabolic process; sphingolipid metabolic process IPR003119; IPR007856; IPR008138; IPR008373; IPR011001; IPR021165; IPR008139; Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)] PSAP Bos taurus (Bovine) TR7285_c2_g1_i1 Q0GGX2 ZN541_MOUSE 5.00E-10 GO:0003677; GO:0030154; GO:0003682; GO:0046872; GO:0007275; GO:0005634; GO:0006355; GO:0007283; GO:0006351 "DNA binding; cell differentiation; chromatin binding; metal ion binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; spermatogenesis; transcription, DNA-dependent" IPR000949; IPR009057; IPR001005; IPR017884; IPR007087; IPR015880; IPR013087; Zinc finger protein 541 (Spermatogenic cell HDAC-interacting protein 1) Znf541 Ship1 Zfp541 Mus musculus (Mouse) TR7289_c0_g1_i1 Q9BRX8 F213A_HUMAN 4.00E-22 GO:0016209; GO:0005737; GO:0005739; GO:0055114; GO:0045670 antioxidant activity; cytoplasm; mitochondrion; oxidation-reduction process; regulation of osteoclast differentiation Redox-regulatory protein FAM213A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) (Protein PAMM) FAM213A C10orf58 PAMM PRO2290 PSEC0139 UNQ611/PRO1198 Homo sapiens (Human) TR7301_c1_g1_i1 Q9FWW6 GSXL1_ARATH 7.00E-26 GO:0004499; GO:0050661; GO:0050660 "N,N-dimethylaniline monooxygenase activity; NADP binding; flavin adenine dinucleotide binding" IPR000960; IPR020946; Flavin-containing monooxygenase FMO GS-OX-like 1 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 1) At1g12160 T28K15.10 Arabidopsis thaliana (Mouse-ear cress) TR7303_c0_g1_i1 Q9VVI9 CHMP5_DROME 2.00E-13 GO:0000815; GO:0015031 ESCRT III complex; protein transport IPR005024; Charged multivesicular body protein 5 CG6259 Drosophila melanogaster (Fruit fly) TR7305_c0_g1_i1 Q504A5 TPMT_DANRE 5.00E-13 GO:0005737; GO:0008119 cytoplasm; thiopurine S-methyltransferase activity IPR025835; IPR008854; Probable thiopurine S-methyltransferase (Thiopurine methyltransferase) (EC 2.1.1.67) tpmt zgc:109981 Danio rerio (Zebrafish) (Brachydanio rerio) TR7306_c2_g1_i1 Q3T0T7 SAR1B_BOVIN 3.00E-21 GO:0005525; GO:0032580; GO:0005789; GO:0006886; GO:0046872; GO:0016192 GTP binding; Golgi cisterna membrane; endoplasmic reticulum membrane; intracellular protein transport; metal ion binding; vesicle-mediated transport IPR027417; IPR005225; IPR006689; IPR006687; GTP-binding protein SAR1b SAR1B Bos taurus (Bovine) TR7318_c1_g1_i1 Q9VLU0 BAF_DROME 3.00E-11 GO:0003677; GO:0005694; GO:0005737; GO:0030717; GO:0005635; GO:0005654 DNA binding; chromosome; cytoplasm; karyosome formation; nuclear envelope; nucleoplasm IPR004122; Barrier-to-autointegration factor baf CG7380 Drosophila melanogaster (Fruit fly) TR7325_c0_g1_i1 Q5RAE3 LAT2_PONAB 3.00E-15 GO:0015171; GO:0016323; GO:0005737; GO:0016021 amino acid transmembrane transporter activity; basolateral plasma membrane; cytoplasm; integral to membrane IPR002293; IPR004760; Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (Solute carrier family 7 member 8) SLC7A8 LAT2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR7327_c0_g1_i1 Q8JZR6 S4A8_MOUSE 7.00E-19 GO:0005452; GO:0016021; GO:0006814 inorganic anion exchanger activity; integral to membrane; sodium ion transport IPR013769; IPR011531; IPR003020; IPR003024; IPR016152; Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na+-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3) Slc4a8 Kiaa0739 Mus musculus (Mouse) TR7330_c1_g1_i1 P24733 MYS_AEQIR 2.00E-13 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR015650; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, striated muscle" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR7338_c0_g1_i1 Q8K3K9 GIMA4_RAT 1.00E-08 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) TR7356_c1_g1_i1 Q05793 PGBM_MOUSE 8.00E-10 GO:0005796; GO:0001525; GO:0005605; GO:0007420; GO:0048738; GO:0060351; GO:0002062; GO:0048704; GO:0001958; GO:0030198; GO:0046872; GO:0008104 Golgi lumen; angiogenesis; basal lamina; brain development; cardiac muscle tissue development; cartilage development involved in endochondral bone morphogenesis; chondrocyte differentiation; embryonic skeletal system morphogenesis; endochondral ossification; extracellular matrix organization; metal ion binding; protein localization IPR008985; IPR013320; IPR000742; IPR013032; IPR002049; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR018031; IPR000034; IPR001791; IPR023415; IPR002172; IPR000082; Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) [Cleaved into: Endorepellin; LG3 peptide] Hspg2 Mus musculus (Mouse) TR736_c0_g1_i1 P34850 NU3M_ANOGA 5.00E-24 GO:0008137; GO:0016021; GO:0031966; GO:0070469 NADH dehydrogenase (ubiquinone) activity; integral to membrane; mitochondrial membrane; respiratory chain IPR000440; NADH-ubiquinone oxidoreductase chain 3 (EC 1.6.5.3) (NADH dehydrogenase subunit 3) mt:ND3 ND3 Anopheles gambiae (African malaria mosquito) TR7364_c0_g1_i1 Q5GH59 XKR4_RAT 4.00E-19 GO:0016021 integral to membrane IPR018629; XK-related protein 4 Xkr4 Xrg4 Rattus norvegicus (Rat) TR7364_c0_g2_i1 Q5GH57 XKR6_RAT 8.00E-18 GO:0016021 integral to membrane IPR018629; XK-related protein 6 Xkr6 Xrg6 Rattus norvegicus (Rat) TR7372_c0_g1_i1 O00750 P3C2B_HUMAN 4.00E-16 GO:0016303; GO:0035005; GO:0005524; GO:0030139; GO:0005783; GO:0043231; GO:0001727; GO:0005634; GO:0005942; GO:0035091; GO:0048015; GO:0005886; GO:0043491; GO:0044281 P00533; P04626; P62993; P16333; P14373 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; endocytic vesicle; endoplasmic reticulum; intracellular membrane-bounded organelle; lipid kinase activity; nucleus; phosphatidylinositol 3-kinase complex; phosphatidylinositol binding; phosphatidylinositol-mediated signaling; plasma membrane; protein kinase B signaling cascade; small molecule metabolic process IPR016024; IPR000008; IPR011009; IPR001683; IPR000403; IPR018936; IPR002420; IPR000341; IPR015433; IPR001263; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta) PIK3C2B Homo sapiens (Human) TR7380_c0_g1_i1 Q8R034 APC13_MOUSE 5.00E-09 GO:0005680; GO:0051301; GO:0007067; GO:0070979 anaphase-promoting complex; cell division; mitosis; protein K11-linked ubiquitination IPR008401; Protein modification; protein ubiquitination. Anaphase-promoting complex subunit 13 (APC13) (Cyclosome subunit 13) Anapc13 Mus musculus (Mouse) TR7382_c0_g1_i1 O13067 CND2_XENLA 4.00E-45 GO:0051301; GO:0005694; GO:0030261; GO:0005829; GO:0007067; GO:0005634 cell division; chromosome; chromosome condensation; cytosol; mitosis; nucleus IPR022816; Condensin complex subunit 2 (Barren homolog) (Chromosome assembly protein xCAP-H) (Chromosome-associated protein H) (Non-SMC condensin I complex subunit H) ncaph brrn1 caph Xenopus laevis (African clawed frog) TR7386_c1_g1_i1 Q61686 CBX5_MOUSE 8.00E-11 GO:0016605; GO:0003682; GO:0010369; GO:0005737; GO:0000118; GO:0035097; GO:0000776; GO:0035064; GO:0045892; GO:0005720; GO:0005730; GO:0017053 Q64127 "PML body; chromatin binding; chromocenter; cytoplasm; histone deacetylase complex; histone methyltransferase complex; kinetochore; methylated histone residue binding; negative regulation of transcription, DNA-dependent; nuclear heterochromatin; nucleolus; transcriptional repressor complex" IPR017984; IPR023780; IPR000953; IPR008251; IPR016197; IPR023779; Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha) Cbx5 Hp1a Mus musculus (Mouse) TR7389_c1_g1_i1 P17608 RYH1_SCHPO 4.00E-15 GO:0005525; GO:0003924; GO:0000139; GO:0071470; GO:0005829; GO:0010008; GO:0006886; GO:0005634; GO:0005886; GO:0042147; GO:0007264 "GTP binding; GTPase activity; Golgi membrane; cellular response to osmotic stress; cytosol; endosome membrane; intracellular protein transport; nucleus; plasma membrane; retrograde transport, endosome to Golgi; small GTPase mediated signal transduction" IPR027417; IPR005225; IPR001806; IPR003579; GTP-binding protein ryh1 ryh1 hos1 its6 SPAC4C5.02c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR7393_c0_g1_i1 Q61127 NAB2_MOUSE 5.00E-08 GO:0014037; GO:0001958; GO:0042552; GO:0016480; GO:0005634; GO:0045682; GO:0008134; GO:0006351 "Schwann cell differentiation; endochondral ossification; myelination; negative regulation of transcription from RNA polymerase III promoter; nucleus; regulation of epidermis development; transcription factor binding; transcription, DNA-dependent" IPR006989; IPR006988; NGFI-A-binding protein 2 (EGR-1-binding protein 2) Nab2 Mus musculus (Mouse) TR7397_c0_g1_i1 Q9Y2C3 B3GT5_HUMAN 6.00E-09 GO:0005794; GO:0000139; GO:0008499; GO:0005783; GO:0016021; GO:0006486 "Golgi apparatus; Golgi membrane; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; endoplasmic reticulum; integral to membrane; protein glycosylation" IPR002659; Protein modification; protein glycosylation. "Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5)" B3GALT5 Homo sapiens (Human) TR740_c0_g1_i1 P0C7P0 CISD3_HUMAN 6.00E-20 GO:0051537; GO:0046872; GO:0005739 "2 iron, 2 sulfur cluster binding; metal ion binding; mitochondrion" IPR018967; IPR006622; "CDGSH iron-sulfur domain-containing protein 3, mitochondrial (MitoNEET-related protein 2) (Miner2)" CISD3 Homo sapiens (Human) TR7403_c1_g1_i1 Q9NY26 S39A1_HUMAN 9.00E-20 GO:0005789; GO:0022890; GO:0016021; GO:0005886; GO:0071577; GO:0005385 endoplasmic reticulum membrane; inorganic cation transmembrane transporter activity; integral to membrane; plasma membrane; zinc ion transmembrane transport; zinc ion transmembrane transporter activity IPR003689; Zinc transporter ZIP1 (Solute carrier family 39 member 1) (Zinc-iron-regulated transporter-like) (Zrt- and Irt-like protein 1) (ZIP-1) (hZIP1) SLC39A1 IRT1 ZIP1 ZIRTL CGI-08 CGI-71 Homo sapiens (Human) TR7404_c1_g1_i1 Q967F4 HMR1_CAEEL 2.00E-08 GO:0003384; GO:0005509; GO:0016342; GO:0042074; GO:0005913; GO:0007016; GO:0000132; GO:0007156; GO:0016021; GO:0007399 O44326 apical constriction involved in gastrulation; calcium ion binding; catenin complex; cell migration involved in gastrulation; cell-cell adherens junction; cytoskeletal anchoring at plasma membrane; establishment of mitotic spindle orientation; homophilic cell adhesion; integral to membrane; nervous system development IPR002126; IPR015919; IPR020894; IPR000233; IPR027397; IPR008985; IPR013320; IPR018247; IPR000742; IPR013032; IPR000152; IPR001791; Cadherin-related hmr-1 (Protein Hammerhead) hmr-1 W02B9.1 Caenorhabditis elegans TR7416_c0_g1_i1 O89110 CASP8_MOUSE 6.00E-13 GO:0030690; GO:0006919; GO:0001525; GO:0071260; GO:0005813; GO:0097153; GO:0031264; GO:0008625; GO:0007507; GO:0097284; GO:0030225; GO:0005739; GO:0043124; GO:0060546; GO:0001841; GO:0043123; GO:2001238; GO:0045651; GO:0045862; GO:0051603; GO:0070243; GO:0034612 P10275; P19091; P25446; Q9D8Y7 Noc1p-Noc2p complex; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; death-inducing signaling complex; extrinsic apoptotic signaling pathway via death domain receptors; heart development; hepatocyte apoptotic process; macrophage differentiation; mitochondrion; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of necroptosis; neural tube formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of macrophage differentiation; positive regulation of proteolysis; proteolysis involved in cellular protein catabolic process; regulation of thymocyte apoptotic process; response to tumor necrosis factor IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] Casp8 Mus musculus (Mouse) TR7416_c2_g1_i1 P55213 CASP3_RAT 4.00E-12 GO:0071407; GO:0004197; GO:0008234; GO:0005829; GO:0034349; GO:0021766; GO:0035556; GO:0007611; GO:0030182; GO:0016005; GO:0043525; GO:0006508; GO:0010165; GO:0043200; GO:0046677; GO:0032025; GO:0042493; GO:0032355; GO:0051384; GO:0009749; GO:0042542; GO:0001666; GO:0032496; GO:0035094; GO:0042060 cellular response to organic cyclic compound; cysteine-type endopeptidase activity; cysteine-type peptidase activity; cytosol; glial cell apoptotic process; hippocampus development; intracellular signal transduction; learning or memory; neuron differentiation; phospholipase A2 activator activity; positive regulation of neuron apoptotic process; proteolysis; response to X-ray; response to amino acid stimulus; response to antibiotic; response to cobalt ion; response to drug; response to estradiol stimulus; response to glucocorticoid stimulus; response to glucose stimulus; response to hydrogen peroxide; response to hypoxia; response to lipopolysaccharide; response to nicotine; wound healing IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (IRP) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] Casp3 Cpp32 Rattus norvegicus (Rat) TR7419_c0_g1_i1 Q8HXX6 SAP3_MACFA 4.00E-20 GO:0016787; GO:0005764; GO:0006665 hydrolase activity; lysosome; sphingolipid metabolic process IPR003172; Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) GM2A QccE-17591 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR7427_c0_g1_i1 O14776 TCRG1_HUMAN 4.00E-46 GO:0001106; GO:0005634; GO:0003713 Q99728; P42858 RNA polymerase II transcription corepressor activity; nucleus; transcription coactivator activity IPR002713; IPR001202; Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) TCERG1 CA150 TAF2S Homo sapiens (Human) TR7431_c0_g1_i1 Q5TGZ0 MOS1_HUMAN 1.00E-31 GO:0016021; GO:0005743; GO:0005739 integral to membrane; mitochondrial inner membrane; mitochondrion IPR007512; Mitochondrial inner membrane organizing system protein 1 MINOS1 C1orf151 Homo sapiens (Human) TR7431_c0_g2_i1 Q7RYI0 MOS1_NEUCR 5.00E-15 GO:0016021; GO:0005743; GO:0005739 integral to membrane; mitochondrial inner membrane; mitochondrion IPR007512; Mitochondrial inner membrane organizing system protein NCU06495 NCU06495 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR7437_c0_g1_i1 Q63HN8 RN213_HUMAN 4.00E-36 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR018957; IPR001841; IPR013083; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) TR7437_c1_g1_i1 E9Q555 RN213_MOUSE 2.00E-32 GO:0016887; GO:0005737; GO:0000166; GO:0051865; GO:0004842; GO:0008270 ATPase activity; cytoplasm; nucleotide binding; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR003593; IPR027417; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) Rnf213 Mus musculus (Mouse) TR7451_c2_g1_i1 P86854 PLCL_MYTGA 1.00E-13 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR7454_c0_g1_i1 O15050 TRNK1_HUMAN 2.00E-15 GO:0005524; GO:0016787 ATP binding; hydrolase activity IPR002110; IPR020683; IPR014017; IPR027417; IPR013026; IPR011990; IPR014016; TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) TR746_c0_g1_i1 P83425 HIP_MYTED 4.00E-08 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR7464_c1_g1_i1 P25291 GP2_CANFA 1.00E-07 GO:0031225; GO:0005576; GO:0005886 anchored to membrane; extracellular region; plasma membrane IPR001507; IPR017977; Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) GP2 Canis familiaris (Dog) (Canis lupus familiaris) TR7467_c0_g1_i1 E1BGH8 MMS22_BOVIN 8.00E-19 GO:0035101; GO:0042555; GO:0000724; GO:0043596; GO:0031297 FACT complex; MCM complex; double-strand break repair via homologous recombination; nuclear replication fork; replication fork processing Protein MMS22-like (Methyl methanesulfonate-sensitivity protein 22-like) MMS22L Bos taurus (Bovine) TR7480_c0_g1_i1 A9JRL3 CBPC1_XENTR 3.00E-16 GO:0035609; GO:0021702; GO:0005829; GO:0001754; GO:0004181; GO:0005739; GO:0007005; GO:0050905; GO:0021772; GO:0035610; GO:0006508; GO:0015631; GO:0008270 C-terminal protein deglutamylation; cerebellar Purkinje cell differentiation; cytosol; eye photoreceptor cell differentiation; metallocarboxypeptidase activity; mitochondrion; mitochondrion organization; neuromuscular process; olfactory bulb development; protein side chain deglutamylation; proteolysis; tubulin binding; zinc ion binding IPR016024; IPR000834; Cytosolic carboxypeptidase 1 (EC 3.4.17.-) (ATP/GTP-binding protein 1) agtpbp1 ccp1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR7501_c0_g1_i1 Q568P9 HENMT_DANRE 9.00E-09 GO:0008171; GO:0043186; GO:0003723; GO:0008173; GO:0031047; GO:0046872; GO:0048599; GO:0034587 O-methyltransferase activity; P granule; RNA binding; RNA methyltransferase activity; gene silencing by RNA; metal ion binding; oocyte development; piRNA metabolic process IPR026610; Small RNA 2'-O-methyltransferase (EC 2.1.1.n8) (HEN1 methyltransferase homolog 1) henmt1 si:ch211-199m3.6 zgc:110175 Danio rerio (Zebrafish) (Brachydanio rerio) TR7503_c0_g1_i1 Q811W2 CP26B_MOUSE 2.00E-28 GO:0060349; GO:0001709; GO:0071300; GO:0030326; GO:0005789; GO:0020037; GO:0005506; GO:0007140; GO:0010628; GO:2001037; GO:0009954; GO:0008401; GO:0001972; GO:0034653; GO:0042573; GO:0048384; GO:0007283; GO:0043587 bone morphogenesis; cell fate determination; cellular response to retinoic acid; embryonic limb morphogenesis; endoplasmic reticulum membrane; heme binding; iron ion binding; male meiosis; positive regulation of gene expression; positive regulation of tongue muscle cell differentiation; proximal/distal pattern formation; retinoic acid 4-hydroxylase activity; retinoic acid binding; retinoic acid catabolic process; retinoic acid metabolic process; retinoic acid receptor signaling pathway; spermatogenesis; tongue morphogenesis IPR001128; IPR017972; IPR002403; Cytochrome P450 26B1 (EC 1.14.-.-) (Cytochrome P450 retinoic acid-inactivating 2) (Cytochrome P450RAI-2) Cyp26b1 Mus musculus (Mouse) TR7505_c0_g1_i1 P10184 IOV7_CHICK 1.00E-09 GO:0005576; GO:0019870; GO:0002020; GO:0043234; GO:0004867 P00766 extracellular region; potassium channel inhibitor activity; protease binding; protein complex; serine-type endopeptidase inhibitor activity IPR002350; Ovoinhibitor OIH Gallus gallus (Chicken) TR7506_c0_g1_i1 P01131 LDLR_BOVIN 4.00E-09 GO:0005794; GO:0009986; GO:0008203; GO:0005905; GO:0005769; GO:0006897; GO:0016021; GO:0005770; GO:0006869; GO:0034362; GO:0005764; GO:0005886 Golgi apparatus; cell surface; cholesterol metabolic process; coated pit; early endosome; endocytosis; integral to membrane; late endosome; lipid transport; low-density lipoprotein particle; lysosome; plasma membrane IPR011042; IPR000742; IPR000033; Low-density lipoprotein receptor (LDL receptor) (Fragment) LDLR Bos taurus (Bovine) TR7508_c0_g1_i1 P17119 KAR3_YEAST 1.00E-14 GO:0005524; GO:0051301; GO:0005881; GO:0000742; GO:0005871; GO:0007126; GO:0008017; GO:0008569; GO:0007064; GO:0000743; GO:0005634; GO:0005816 P32908; Q12045 ATP binding; cell division; cytoplasmic microtubule; karyogamy involved in conjugation with cellular fusion; kinesin complex; meiosis; microtubule binding; minus-end-directed microtubule motor activity; mitotic sister chromatid cohesion; nuclear migration involved in conjugation with cellular fusion; nucleus; spindle pole body IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KAR3 (Nuclear fusion protein) KAR3 YPR141C P9659.16 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR7508_c2_g1_i1 O35231 KIFC3_MOUSE 1.00E-45 GO:0005524; GO:0005794; GO:0007030; GO:0005813; GO:0030659; GO:0090136; GO:0005871; GO:0005874; GO:0007018; GO:0007017; GO:0008569; GO:0005915; GO:0045218 ATP binding; Golgi apparatus; Golgi organization; centrosome; cytoplasmic vesicle membrane; epithelial cell-cell adhesion; kinesin complex; microtubule; microtubule-based movement; microtubule-based process; minus-end-directed microtubule motor activity; zonula adherens; zonula adherens maintenance IPR027640; IPR019821; IPR001752; IPR027417; Kinesin-like protein KIFC3 Kifc3 Mus musculus (Mouse) TR751_c0_g1_i1 Q9BYK8 PR285_HUMAN 1.00E-13 GO:0005524; GO:0003677; GO:0044255; GO:0004386; GO:0030374; GO:0046872; GO:0005654; GO:0045944; GO:0044281; GO:0006351 "ATP binding; DNA binding; cellular lipid metabolic process; helicase activity; ligand-dependent nuclear receptor transcription coactivator activity; metal ion binding; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; small molecule metabolic process; transcription, DNA-dependent" IPR003593; IPR026122; IPR012340; IPR027417; IPR022966; IPR015880; "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) TR7517_c0_g1_i1 P24014 SLIT_DROME 3.00E-06 GO:0035385; GO:0071666; GO:0016199; GO:0005509; GO:0048813; GO:0007502; GO:0035050; GO:0007427; GO:0008347; GO:0008406; GO:0008201; GO:0050929; GO:0046331; GO:0008078; GO:0001764; GO:0003151; GO:0005886; GO:0022409; GO:0005578; GO:2000274; GO:0007432 "Roundabout signaling pathway; Slit-Robo signaling complex; axon midline choice point recognition; calcium ion binding; dendrite morphogenesis; digestive tract mesoderm development; embryonic heart tube development; epithelial cell migration, open tracheal system; glial cell migration; gonad development; heparin binding; induction of negative chemotaxis; lateral inhibition; mesodermal cell migration; neuron migration; outflow tract morphogenesis; plasma membrane; positive regulation of cell-cell adhesion; proteinaceous extracellular matrix; regulation of epithelial cell migration, open tracheal system; salivary gland boundary specification" IPR008985; IPR013320; IPR000483; IPR006207; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; IPR001611; IPR003591; IPR000372; IPR026906; Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) TR7519_c0_g2_i1 P17972 KCNAW_DROME 3.00E-20 GO:0005251; GO:0051260; GO:0030431; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; sleep; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR015572; IPR003131; IPR028325; Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) TR7524_c0_g1_i1 Q9D115 ZN706_MOUSE 3.00E-14 GO:0046872 metal ion binding IPR007513; IPR026939; IPR015880; Zinc finger protein 706 Znf706 Zfp706 Mus musculus (Mouse) TR7524_c0_g2_i1 Q9D115 ZN706_MOUSE 4.00E-14 GO:0046872 metal ion binding IPR007513; IPR026939; IPR015880; Zinc finger protein 706 Znf706 Zfp706 Mus musculus (Mouse) TR7527_c2_g1_i1 Q10711 ECE2_BOVIN 2.00E-13 GO:0000139; GO:0007420; GO:0010002; GO:0030659; GO:0009790; GO:0016021; GO:0046872; GO:0004222; GO:0008168; GO:0016486; GO:0042803; GO:0006508; GO:0008277; GO:0042310 Golgi membrane; brain development; cardioblast differentiation; cytoplasmic vesicle membrane; embryo development; integral to membrane; metal ion binding; metalloendopeptidase activity; methyltransferase activity; peptide hormone processing; protein homodimerization activity; proteolysis; regulation of G-protein coupled receptor protein signaling pathway; vasoconstriction IPR024079; IPR013216; IPR000718; IPR018497; IPR008753; Endothelin-converting enzyme 2 (ECE-2) [Includes: Methyltransferase-like region (EC 2.1.1.-); Endothelin-converting enzyme 2 region (EC 3.4.24.71)] ECE2 Bos taurus (Bovine) TR7528_c0_g1_i1 Q8WYP5 ELYS_HUMAN 9.00E-13 GO:0003677; GO:0000777; GO:0000910; GO:0005829; GO:0051028; GO:0000278; GO:0016363; GO:0031965; GO:0005643; GO:0051292; GO:0005654; GO:0015031; GO:0003700 DNA binding; condensed chromosome kinetochore; cytokinesis; cytosol; mRNA transport; mitotic cell cycle; nuclear matrix; nuclear membrane; nuclear pore; nuclear pore complex assembly; nucleoplasm; protein transport; sequence-specific DNA binding transcription factor activity IPR017956; IPR025151; IPR011047; Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) AHCTF1 ELYS TMBS62 MSTP108 Homo sapiens (Human) TR7529_c1_g1_i1 Q8BNE1 F115A_MOUSE 1.00E-11 Protein FAM115A Fam115a Kiaa0738 Mus musculus (Mouse) TR7531_c0_g1_i1 A2AJ76 HMCN2_MOUSE 3.00E-07 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 Hmcn2 Mus musculus (Mouse) TR7536_c0_g1_i1 O70191 ATF5_MOUSE 5.00E-13 GO:0005737; GO:0035264; GO:0043066; GO:0005634; GO:0021891; GO:0009791; GO:0006357; GO:0043565; GO:0003700; GO:0005667; GO:0006351 "cytoplasm; multicellular organism growth; negative regulation of apoptotic process; nucleus; olfactory bulb interneuron development; post-embryonic development; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; transcription, DNA-dependent" IPR004827; Cyclic AMP-dependent transcription factor ATF-5 (cAMP-dependent transcription factor ATF-5) (Activating transcription factor 5-alpha/beta) (BZIP protein ATF7) (NAP1) (NRIF3-associated protein) (Transcription factor ATFx) (Transcription factor-like protein ODA-10) Atf5 Atfx Nap1 Mus musculus (Mouse) TR7548_c0_g1_i1 Q6UXB8 PI16_HUMAN 9.00E-06 GO:0005576; GO:0016021; GO:0030414 extracellular region; integral to membrane; peptidase inhibitor activity IPR001283; IPR018244; IPR014044; Peptidase inhibitor 16 (PI-16) (Cysteine-rich secretory protein 9) (CRISP-9) (PSP94-binding protein) PI16 CRISP9 PSPBP PSEC0164 UNQ289/PRO328 Homo sapiens (Human) TR7560_c0_g1_i1 P92523 M860_ARATH 3.00E-24 GO:0005739 mitochondrion Uncharacterized mitochondrial protein AtMg00860 (ORF158) AtMg00860 Arabidopsis thaliana (Mouse-ear cress) TR7575_c0_g1_i1 Q96QK1 VPS35_HUMAN 1.00E-40 GO:0008219; GO:0005829; GO:0005768; GO:0005765; GO:0015031; GO:0042147 "cell death; cytosol; endosome; lysosomal membrane; protein transport; retrograde transport, endosome to Golgi" IPR016024; IPR005378; Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) VPS35 MEM3 TCCCTA00141 Homo sapiens (Human) TR7578_c0_g2_i1 A6NHR9 SMHD1_HUMAN 3.00E-22 GO:0005524; GO:0001740; GO:0051276; GO:0060821 ATP binding; Barr body; chromosome organization; inactivation of X chromosome by DNA methylation IPR003594; IPR010935; Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) SMCHD1 KIAA0650 Homo sapiens (Human) TR7582_c0_g1_i1 G5E8K5 ANK3_MOUSE 1.00E-33 GO:0007411; GO:0043194; GO:0005856; GO:0014704; GO:0005764; GO:0016020; GO:0033268; GO:0033270; GO:0045760; GO:0045211; GO:0072661; GO:0019228; GO:0042383; GO:0007165; GO:0045202; GO:0050808 axon guidance; axon initial segment; cytoskeleton; intercalated disc; lysosome; membrane; node of Ranvier; paranode region of axon; positive regulation of action potential; postsynaptic membrane; protein targeting to plasma membrane; regulation of action potential in neuron; sarcolemma; signal transduction; synapse; synapse organization IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) TR7584_c0_g1_i1 Q5ZI11 LRC45_CHICK 1.00E-20 Leucine-rich repeat-containing protein 45 LRRC45 RCJMB04_31i7 Gallus gallus (Chicken) TR7589_c3_g1_i1 Q9NZS9 BFAR_HUMAN 1.00E-24 GO:0006915; GO:0005789; GO:0005887; GO:0043066; GO:0005198; GO:0008270 apoptotic process; endoplasmic reticulum membrane; integral to plasma membrane; negative regulation of apoptotic process; structural molecule activity; zinc ion binding IPR001660; IPR013761; IPR021129; IPR001841; IPR013083; IPR017907; Bifunctional apoptosis regulator (RING finger protein 47) BFAR BAR RNF47 Homo sapiens (Human) TR7589_c4_g1_i1 Q8R0K2 TRI31_MOUSE 4.00E-10 GO:0016874; GO:0005739; GO:0016567; GO:0008270 ligase activity; mitochondrion; protein ubiquitination; zinc ion binding IPR001870; IPR003879; IPR008985; IPR006574; IPR003877; IPR000315; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM31 (EC 6.3.2.-) (Tripartite motif-containing protein 31) Trim31 Mus musculus (Mouse) TR7601_c0_g1_i1 A6NHR9 SMHD1_HUMAN 9.00E-18 GO:0005524; GO:0001740; GO:0051276; GO:0060821 ATP binding; Barr body; chromosome organization; inactivation of X chromosome by DNA methylation IPR003594; IPR010935; Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) SMCHD1 KIAA0650 Homo sapiens (Human) TR7604_c0_g1_i1 P36404 ARL2_HUMAN 7.00E-66 GO:0019003; GO:0005525; GO:0003924; GO:0005095; GO:0007049; GO:0005813; GO:0051297; GO:0016328; GO:0051457; GO:0005758; GO:0034260; GO:0005634; GO:0010811; GO:0031116; GO:0007264; GO:0070830; GO:0007021 O43924; Q13432 GDP binding; GTP binding; GTPase activity; GTPase inhibitor activity; cell cycle; centrosome; centrosome organization; lateral plasma membrane; maintenance of protein location in nucleus; mitochondrial intermembrane space; negative regulation of GTPase activity; nucleus; positive regulation of cell-substrate adhesion; positive regulation of microtubule polymerization; small GTPase mediated signal transduction; tight junction assembly; tubulin complex assembly IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 2 ARL2 Homo sapiens (Human) TR7613_c0_g1_i1 Q6I9Y2 THOC7_HUMAN 4.00E-59 GO:0003723; GO:0008380; GO:0000445; GO:0005737; GO:0046784; GO:0006397 Q13769 RNA binding; RNA splicing; THO complex part of transcription export complex; cytoplasm; intronless viral mRNA export from host nucleus; mRNA processing IPR008501; THO complex subunit 7 homolog (Functional spliceosome-associated protein 24) (fSAP24) (Ngg1-interacting factor 3-like protein 1-binding protein 1) (NIF3L1-binding protein 1) (hTREX30) THOC7 NIF3L1BP1 Homo sapiens (Human) TR7630_c0_g1_i1 Q4UMH6 Y381_RICFE 9.00E-11 GO:0015969 guanosine tetraphosphate metabolic process IPR002110; IPR020683; IPR007685; Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR7636_c0_g1_i1 Q8TEW0 PARD3_HUMAN 2.00E-26 GO:0003383; GO:0045177; GO:0008356; GO:0044295; GO:0007409; GO:0005938; GO:0007049; GO:0005913; GO:0051642; GO:0005829; GO:0012505; GO:0090162; GO:0000226; GO:0043025; GO:0005547; GO:0032266; GO:0005546; GO:0005886; GO:0006461; GO:0007205; GO:0006612; GO:0032970; GO:0060341; GO:0005819; GO:0005923; GO:0070830; GO:0007179; GO:0044319 P33151; Q9Y624; Q9NPB6; Q9BYG5; Q9JK83; Q9BYG4; Q8ND90; P41743; Q60610; Q6ZPF3; P04637; Q04917; P63104 "apical constriction; apical part of cell; asymmetric cell division; axonal growth cone; axonogenesis; cell cortex; cell cycle; cell-cell adherens junction; centrosome localization; cytosol; endomembrane system; establishment of epithelial cell polarity; microtubule cytoskeleton organization; neuronal cell body; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4,5-bisphosphate binding; plasma membrane; protein complex assembly; protein kinase C-activating G-protein coupled receptor signaling pathway; protein targeting to membrane; regulation of actin filament-based process; regulation of cellular localization; spindle; tight junction; tight junction assembly; transforming growth factor beta receptor signaling pathway; wound healing, spreading of cells" IPR021922; IPR001478; Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) PARD3 PAR3 PAR3A Homo sapiens (Human) TR7646_c0_g1_i1 P40392 RIC1_ORYSJ 2.00E-22 GO:0005525; GO:0005886; GO:0015031; GO:0007264 GTP binding; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein RIC1 RIC1 Os01g0558600 LOC_Os01g37800 B1064G04.9 B1144D11.31 Oryza sativa subsp. japonica (Rice) TR7646_c0_g2_i1 Q6NYB7 RAB1A_RAT 4.00E-22 GO:0006888; GO:0005525; GO:0000139; GO:0032482; GO:0005789; GO:0043025; GO:0015031 ER to Golgi vesicle-mediated transport; GTP binding; Golgi membrane; Rab protein signal transduction; endoplasmic reticulum membrane; neuronal cell body; protein transport IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-1A Rab1A Rab1 Rattus norvegicus (Rat) TR7647_c0_g1_i1 P16295 FA9_CAVPO 6.00E-09 GO:0007596; GO:0005576; GO:0006508; GO:0004252 blood coagulation; extracellular region; proteolysis; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Coagulation factor IX (EC 3.4.21.22) (Christmas factor) (Fragment) F9 Cavia porcellus (Guinea pig) TR7650_c0_g1_i1 Q9WYG0 Y325_THEMA 9.00E-15 GO:0016491 oxidoreductase activity IPR002198; IPR002347; IPR016040; IPR020904; Uncharacterized oxidoreductase TM_0325 (EC 1.-.-.-) TM_0325 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR7650_c0_g2_i1 Q9MYP6 DHB14_BOVIN 6.00E-28 GO:0005813; GO:0005829; GO:0004303; GO:0006706; GO:0047045 centrosome; cytosol; estradiol 17-beta-dehydrogenase activity; steroid catabolic process; testosterone 17-beta-dehydrogenase (NADP+) activity IPR002198; IPR002347; IPR016040; IPR020904; 17-beta-hydroxysteroid dehydrogenase 14 (17-beta-HSD 14) (EC 1.1.1.-) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) HSD17B14 DHRS10 SDR3 Bos taurus (Bovine) TR7653_c0_g1_i1 Q8K1T0 TMPS3_MOUSE 1.00E-06 GO:0006883; GO:0005783; GO:0005789; GO:0016021; GO:0043025; GO:0006508; GO:0005044; GO:0007605; GO:0004252; GO:0017080 cellular sodium ion homeostasis; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; neuronal cell body; proteolysis; scavenger receptor activity; sensory perception of sound; serine-type endopeptidase activity; sodium channel regulator activity IPR023415; IPR002172; IPR001254; IPR018114; IPR001314; IPR001190; IPR017448; IPR009003; Transmembrane protease serine 3 (EC 3.4.21.-) Tmprss3 Mus musculus (Mouse) TR7658_c0_g1_i1 O88700 BLM_MOUSE 1.00E-34 GO:0005524; GO:0043140; GO:0003677; GO:0000729; GO:0006310; GO:0006260; GO:0046632; GO:0072757; GO:0072711; GO:0071479; GO:0005737; GO:0001673; GO:0045950; GO:0070244; GO:0000228; GO:0005654; GO:0046641; GO:0045120; GO:0051098; GO:0005657; GO:0000723 ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA binding; DNA double-strand break processing; DNA recombination; DNA replication; alpha-beta T cell differentiation; cellular response to camptothecin; cellular response to hydroxyurea; cellular response to ionizing radiation; cytoplasm; male germ cell nucleus; negative regulation of mitotic recombination; negative regulation of thymocyte apoptotic process; nuclear chromosome; nucleoplasm; positive regulation of alpha-beta T cell proliferation; pronucleus; regulation of binding; replication fork; telomere maintenance IPR012532; IPR011545; IPR002464; IPR004589; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR018982; IPR011991; Bloom syndrome protein homolog (mBLM) (EC 3.6.4.12) (RecQ helicase homolog) Blm Mus musculus (Mouse) TR7663_c0_g2_i1 Q60934 GRIK1_MOUSE 1.00E-09 GO:0030534; GO:0048266; GO:0030054; GO:0030425; GO:0005234; GO:0015277; GO:0032983; GO:0051967; GO:0014054; GO:0032230; GO:0045211; GO:0042734; GO:0060079; GO:0060080; GO:0048169; GO:0048172; GO:0035249 "adult behavior; behavioral response to pain; cell junction; dendrite; extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity; kainate selective glutamate receptor complex; negative regulation of synaptic transmission, glutamatergic; positive regulation of gamma-aminobutyric acid secretion; positive regulation of synaptic transmission, GABAergic; postsynaptic membrane; presynaptic membrane; regulation of excitatory postsynaptic membrane potential; regulation of inhibitory postsynaptic membrane potential; regulation of long-term neuronal synaptic plasticity; regulation of short-term neuronal synaptic plasticity; synaptic transmission, glutamatergic" IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; "Glutamate receptor ionotropic, kainate 1 (GluK1) (Glutamate receptor 5) (GluR-5) (GluR5)" Grik1 Glur5 Mus musculus (Mouse) TR7669_c0_g1_i1 Q9WVA4 TAGL2_MOUSE 4.00E-33 GO:0007517 muscle organ development IPR000557; IPR001715; IPR003096; IPR001061; Transgelin-2 (SM22-beta) Tagln2 Kiaa0120 Mus musculus (Mouse) TR7669_c0_g2_i1 Q9WVA4 TAGL2_MOUSE 4.00E-33 GO:0007517 muscle organ development IPR000557; IPR001715; IPR003096; IPR001061; Transgelin-2 (SM22-beta) Tagln2 Kiaa0120 Mus musculus (Mouse) TR7670_c0_g1_i1 Q25381 ACTM_LYTPI 4.00E-73 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; "Actin, muscle (LPM) (Fragment)" Lytechinus pictus (Painted sea urchin) TR7677_c0_g1_i1 O61463 RLA2_CRYST 5.00E-26 GO:0005840; GO:0003735; GO:0006414 ribosome; structural constituent of ribosome; translational elongation IPR001813; IPR027534; 60S acidic ribosomal protein P2 Cryptochiton stelleri (Giant gumboot chiton) TR7679_c0_g1_i1 Q9UG22 GIMA2_HUMAN 5.00E-06 GO:0005525; GO:0016021; GO:0005811 GTP binding; integral to membrane; lipid particle IPR006703; IPR027417; GTPase IMAP family member 2 (Immunity-associated protein 2) (hIMAP2) GIMAP2 IMAP2 Homo sapiens (Human) TR7680_c0_g1_i1 Q91ZX1 C209A_MOUSE 8.00E-13 GO:0009986; GO:0006897; GO:0016021; GO:0005537; GO:0046872 cell surface; endocytosis; integral to membrane; mannose binding; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; CD209 antigen-like protein A (Dendritic cell-specific ICAM-3-grabbing non-integrin) (DC-SIGN) (CD antigen CD209) Cd209a Cire Mus musculus (Mouse) TR7681_c0_g1_i1 Q7ZX75 LMBRL_XENLA 9.00E-45 GO:0006897; GO:0016021; GO:0005886 endocytosis; integral to membrane; plasma membrane IPR008075; IPR006876; Protein LMBR1L lmbr1l Xenopus laevis (African clawed frog) TR7683_c1_g1_i1 Q9CR41 HYPK_MOUSE 1.00E-15 GO:0005737; GO:0005634 cytoplasm; nucleus Huntingtin-interacting protein K (Huntingtin yeast partner K) Hypk Mus musculus (Mouse) TR7693_c0_g1_i1 Q9VLS1 KPBB_DROME 2.00E-38 GO:0005977; GO:0004553; GO:0005886 "glycogen metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; plasma membrane" IPR008928; IPR012341; IPR011613; IPR008734; Glycan biosynthesis; glycogen metabolism. Probable phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta) CG8475 Drosophila melanogaster (Fruit fly) TR7706_c1_g1_i1 P05505 COX3_RAT 7.00E-42 GO:0019646; GO:0004129; GO:0016021; GO:0005743; GO:0045277; GO:0008535 aerobic electron transport chain; cytochrome-c oxidase activity; integral to membrane; mitochondrial inner membrane; respiratory chain complex IV; respiratory chain complex IV assembly IPR024791; IPR000298; IPR013833; Cytochrome c oxidase subunit 3 (Cytochrome c oxidase polypeptide III) Mtco3 Coiii mt-Co3 Rattus norvegicus (Rat) TR7707_c1_g1_i1 Q7Z3E1 PARPT_HUMAN 2.00E-18 GO:0003950; GO:0008209; GO:0008210; GO:0060325; GO:0008585; GO:0030097; GO:0001822; GO:0046872; GO:0044236; GO:0006807; GO:0060021; GO:0048008; GO:0009791; GO:0006471; GO:0048705; GO:0048745; GO:0001570 NAD+ ADP-ribosyltransferase activity; androgen metabolic process; estrogen metabolic process; face morphogenesis; female gonad development; hemopoiesis; kidney development; metal ion binding; multicellular organismal metabolic process; nitrogen compound metabolic process; palate development; platelet-derived growth factor receptor signaling pathway; post-embryonic development; protein ADP-ribosylation; skeletal system morphogenesis; smooth muscle tissue development; vasculogenesis IPR012317; IPR004170; IPR000571; TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) TIPARP PARP7 Homo sapiens (Human) TR7715_c0_g1_i1 Q9JLY0 SOCS6_MOUSE 2.00E-12 GO:0005829; GO:0001772; GO:0035556; GO:0050868; GO:0009968; GO:0010498; GO:0016567; GO:0040008 Q9BYM8 cytosol; immunological synapse; intracellular signal transduction; negative regulation of T cell activation; negative regulation of signal transduction; proteasomal protein catabolic process; protein ubiquitination; regulation of growth IPR000980; IPR001496; Protein modification; protein ubiquitination. Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4) Socs6 Cis4 Cish4 Socs4 Mus musculus (Mouse) TR7717_c1_g1_i1 Q9UHV7 MED13_HUMAN 3.00E-81 GO:0001104; GO:0030521; GO:0030374; GO:0016592; GO:0045944; GO:0004872; GO:0046966; GO:0006367; GO:0042809 RNA polymerase II transcription cofactor activity; androgen receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; positive regulation of transcription from RNA polymerase II promoter; receptor activity; thyroid hormone receptor binding; transcription initiation from RNA polymerase II promoter; vitamin D receptor binding IPR009401; IPR021643; Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) MED13 ARC250 KIAA0593 THRAP1 TRAP240 Homo sapiens (Human) TR772_c0_g1_i1 Q9GKW8 AND1A_MACFA 8.00E-31 GO:0007165 signal transduction IPR002110; IPR020683; IPR011029; IPR000488; Ankyrin repeat and death domain-containing protein 1A (Fragment) ANKDD1A QccE-18247 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR7720_c1_g1_i1 A3KPP4 S2535_DANRE 1.00E-23 GO:0016021; GO:0005743; GO:0006810 integral to membrane; mitochondrial inner membrane; transport IPR018108; IPR023395; Solute carrier family 25 member 35 slc25a35 si:ch211-268m12.5 Danio rerio (Zebrafish) (Brachydanio rerio) TR7721_c0_g1_i1 Q10914 GLR2_CAEEL 3.00E-09 GO:0030054; GO:0005234; GO:0016021; GO:0004970; GO:0035235; GO:0045211 cell junction; extracellular-glutamate-gated ion channel activity; integral to membrane; ionotropic glutamate receptor activity; ionotropic glutamate receptor signaling pathway; postsynaptic membrane IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; Glutamate receptor 2 glr-2 B0280.12/K04G7.2 Caenorhabditis elegans TR773_c0_g1_i1 A2A935 PRD16_MOUSE 3.00E-12 GO:0050873; GO:0046872; GO:0030853; GO:0000122; GO:0030512; GO:0022008; GO:0060021; GO:0045893; GO:0043457; GO:0043565; GO:0035019; GO:0043586; GO:0003713; GO:0006351; GO:0017053; GO:0050872 "brown fat cell differentiation; metal ion binding; negative regulation of granulocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; neurogenesis; palate development; positive regulation of transcription, DNA-dependent; regulation of cellular respiration; sequence-specific DNA binding; somatic stem cell maintenance; tongue development; transcription coactivator activity; transcription, DNA-dependent; transcriptional repressor complex; white fat cell differentiation" IPR001214; IPR007087; IPR015880; IPR013087; PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) Prdm16 Kiaa1675 Mel1 Mus musculus (Mouse) TR7734_c1_g1_i1 Q9P2K1 C2D2A_HUMAN 5.00E-78 GO:0036038; GO:0042384; GO:0005737; GO:0005932; GO:0007224 TCTN-B9D complex; cilium assembly; cytoplasm; microtubule basal body; smoothened signaling pathway IPR000008; Coiled-coil and C2 domain-containing protein 2A CC2D2A KIAA1345 Homo sapiens (Human) TR7741_c0_g1_i1 Q8BQB6 F154B_MOUSE 4.00E-20 IPR024963; Protein FAM154B Fam154b Mus musculus (Mouse) TR7753_c0_g1_i1 Q9VCA8 ANKHM_DROME 2.00E-09 GO:0003723; GO:0019730; GO:0051298; GO:0001751; GO:0005811; GO:0043066; GO:0046427; GO:0007169 RNA binding; antimicrobial humoral response; centrosome duplication; compound eye photoreceptor cell differentiation; lipid particle; negative regulation of apoptotic process; positive regulation of JAK-STAT cascade; transmembrane receptor protein tyrosine kinase signaling pathway IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) TR7767_c0_g1_i1 B4GQJ7 WDY_DROPE 1.00E-13 GO:0005509; GO:0003824; GO:0008152 calcium ion binding; catalytic activity; metabolic process IPR011992; IPR011041; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein on Y chromosome (WD40 Y) WDY GL16195 Drosophila persimilis (Fruit fly) TR7768_c0_g1_i1 P11799 MYLK_CHICK 3.00E-11 GO:0005524; GO:0005829; GO:0016020; GO:0046872; GO:0004687 ATP binding; cytosol; membrane; metal ion binding; myosin light chain kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR020675; IPR000719; IPR017441; IPR002290; IPR008271; "Myosin light chain kinase, smooth muscle (MLCK) (EC 2.7.11.18) (Telokin)" Gallus gallus (Chicken) TR7768_c0_g2_i1 O02827 MYLK_SHEEP 2.00E-11 GO:0005524; GO:0032154; GO:0005737; GO:0005856; GO:0030027; GO:0046872; GO:0004687 ATP binding; cleavage furrow; cytoplasm; cytoskeleton; lamellipodium; metal ion binding; myosin light chain kinase activity IPR007110; IPR013783; IPR013098; IPR003598; IPR011009; IPR020675; IPR000719; IPR002290; IPR008271; "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] (Fragment)" MYLK Ovis aries (Sheep) TR7785_c0_g1_i1 Q7M3K2 PELET_DROME 3.00E-15 GO:0015074; GO:0003693; GO:0046872; GO:0016740; GO:0004803; GO:0006313 "DNA integration; P-element binding; metal ion binding; transferase activity; transposase activity; transposition, DNA-mediated" IPR022242; IPR021896; IPR006612; Transposable element P transposase (P-element transposase) (EC 2.7.7.-) (THAP domain-containing protein) (DmTHAP) T Drosophila melanogaster (Fruit fly) TR7795_c0_g2_i1 Q8CGB3 UACA_MOUSE 1.00E-09 GO:0043293; GO:0005856; GO:0008630; GO:0008631; GO:0016020; GO:0005739; GO:0042347; GO:0050728; GO:0005635; GO:0048471; GO:0043065; GO:0043280; GO:0042307; GO:0009411 apoptosome; cytoskeleton; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to oxidative stress; membrane; mitochondrion; negative regulation of NF-kappaB import into nucleus; negative regulation of inflammatory response; nuclear envelope; perinuclear region of cytoplasm; positive regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of protein import into nucleus; response to UV IPR002110; IPR020683; IPR000727; Uveal autoantigen with coiled-coil domains and ankyrin repeats (Nuclear membrane-binding protein) (Nucling) Uaca Kiaa1561 Mus musculus (Mouse) TR7795_c1_g1_i1 Q9ULJ7 ANR50_HUMAN 1.00E-21 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) TR780_c0_g1_i1 Q9U6A0 NCKX_DROME 2.00E-24 GO:0008273; GO:0048749; GO:0016021; GO:0048812; GO:0015293 "calcium, potassium:sodium antiporter activity; compound eye development; integral to membrane; neuron projection morphogenesis; symporter activity" IPR004481; IPR004837; Sodium/potassium/calcium exchanger Nckx30C (Na(+)/K(+)/Ca(2+)-exchange protein Nckx30C) Nckx30C CG18660 Drosophila melanogaster (Fruit fly) TR7805_c0_g1_i1 Q5UPG5 YL093_MIMIV 4.00E-36 IPR002110; IPR020683; Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) TR7817_c0_g1_i1 P25286 VPP1_RAT 7.00E-06 GO:0015991; GO:0030659; GO:0015078; GO:0016021; GO:0042470; GO:0000220 "ATP hydrolysis coupled proton transport; cytoplasmic vesicle membrane; hydrogen ion transmembrane transporter activity; integral to membrane; melanosome; vacuolar proton-transporting V-type ATPase, V0 domain" IPR002490; IPR026028; V-type proton ATPase 116 kDa subunit a isoform 1 (V-ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1) Atp6v0a1 Atp6n1 Vpp1 Rattus norvegicus (Rat) TR7821_c0_g2_i1 Q6P026 BAF_DANRE 1.00E-06 GO:0003677; GO:0005694; GO:0005634 DNA binding; chromosome; nucleus IPR004122; Barrier-to-autointegration factor banf1 baf zgc:77767 Danio rerio (Zebrafish) (Brachydanio rerio) TR7821_c0_g2_i2 Q6P026 BAF_DANRE 4.00E-07 GO:0003677; GO:0005694; GO:0005634 DNA binding; chromosome; nucleus IPR004122; Barrier-to-autointegration factor banf1 baf zgc:77767 Danio rerio (Zebrafish) (Brachydanio rerio) TR7825_c0_g1_i1 Q61493 DPOLZ_MOUSE 3.00E-30 GO:0051539; GO:0003677; GO:0006260; GO:0003887; GO:0005694; GO:0046872; GO:0000166; GO:0005634; GO:0019985; GO:0016035 "4 iron, 4 sulfur cluster binding; DNA binding; DNA replication; DNA-directed DNA polymerase activity; chromosome; metal ion binding; nucleotide binding; nucleus; translesion synthesis; zeta DNA polymerase complex" IPR006172; IPR017964; IPR006133; IPR006134; IPR023211; IPR012337; IPR025687; DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (Seizure-related protein 4) Rev3l Polz Sez4 Mus musculus (Mouse) TR7829_c0_g1_i1 O02695 PTPR2_MACNE 1.00E-11 GO:0016021; GO:0035335; GO:0004725; GO:0030658 integral to membrane; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; transport vesicle membrane IPR021613; IPR000387; IPR016130; IPR000242; Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.48) (M1851) PTPRN2 Macaca nemestrina (Pig-tailed macaque) TR7833_c1_g1_i1 Q54M77 ROCO8_DICDI 9.00E-12 GO:0005524; GO:0035556; GO:0004674 ATP binding; intracellular signal transduction; protein serine/threonine kinase activity IPR000591; IPR011009; IPR001611; IPR027417; IPR000719; IPR017441; IPR020859; IPR001245; IPR008271; IPR011991; Probable serine/threonine-protein kinase roco8 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 8) roco8 DDB_G0286127 Dictyostelium discoideum (Slime mold) TR7844_c0_g1_i1 Q9V4M2 WECH_DROME 1.00E-05 GO:0030154; GO:0002168; GO:0005622; GO:0016203; GO:0005927; GO:0033632; GO:0008270 cell differentiation; instar larval development; intracellular; muscle attachment; muscle tendon junction; regulation of cell-cell adhesion mediated by integrin; zinc ion binding IPR011042; IPR001258; IPR013017; IPR000315; Protein wech (Protein dappled) wech dpld CG42396 Drosophila melanogaster (Fruit fly) TR7854_c0_g1_i1 O15943 CADN_DROME 7.00E-47 GO:0045467; GO:0045463; GO:0030424; GO:0048846; GO:0007412; GO:0007413; GO:0008013; GO:0005509; GO:0016339; GO:0050839; GO:0044331; GO:0005911; GO:0030425; GO:0007156; GO:0005887; GO:0050774; GO:0016318; GO:0004872; GO:0048841; GO:0031290 R7 cell development; R8 cell development; axon; axon extension involved in axon guidance; axon target recognition; axonal fasciculation; beta-catenin binding; calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; cell-cell adhesion mediated by cadherin; cell-cell junction; dendrite; homophilic cell adhesion; integral to plasma membrane; negative regulation of dendrite morphogenesis; ommatidial rotation; receptor activity; regulation of axon extension involved in axon guidance; retinal ganglion cell axon guidance IPR002126; IPR015919; IPR020894; IPR000233; IPR027397; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR009030; IPR001791; Neural-cadherin (Cadherin-N) (dN-cadherin) CadN CG7100 Drosophila melanogaster (Fruit fly) TR7864_c1_g1_i1 Q2LE78 BTBD6_XENLA 1.00E-15 GO:0000932 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 6 btbd6 Xenopus laevis (African clawed frog) TR7885_c0_g1_i1 Q6IWZ0 OXLA_APLCA 4.00E-20 GO:0001716; GO:0042742; GO:0050832; GO:0005576; GO:0031640 L-amino-acid oxidase activity; defense response to bacterium; defense response to fungus; extracellular region; killing of cells of other organism IPR002937; L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) (Escapin) Aplysia californica (California sea hare) TR7896_c0_g1_i1 O42409 GFI1B_CHICK 6.00E-39 GO:0003677; GO:0016568; GO:0007275; GO:0016363; GO:0006355; GO:0005667; GO:0006351; GO:0008270 "DNA binding; chromatin modification; multicellular organismal development; nuclear matrix; regulation of transcription, DNA-dependent; transcription factor complex; transcription, DNA-dependent; zinc ion binding" IPR007087; IPR015880; IPR013087; IPR001878; Zinc finger protein Gfi-1b (Growth factor-independent protein 1B) GFI1B GFI Gallus gallus (Chicken) TR7897_c1_g1_i1 Q32LN0 EHF_BOVIN 9.00E-07 GO:0030855; GO:0005634; GO:0045893; GO:0043565; GO:0003700; GO:0006351 "epithelial cell differentiation; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000418; IPR003118; IPR013761; IPR011991; ETS homologous factor (ETS domain-containing transcription factor) EHF Bos taurus (Bovine) TR7897_c2_g1_i1 P29775 ETS4_DROME 2.00E-24 GO:0005634; GO:0043565; GO:0003700 nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity IPR000418; IPR003118; IPR013761; IPR011991; DNA-binding protein D-ETS-4 Ets98B ETS-4 CG5583 Drosophila melanogaster (Fruit fly) TR79_c0_g1_i1 P62278 RS13_RAT 6.00E-100 GO:0022627; GO:0003735; GO:0006412 cytosolic small ribosomal subunit; structural constituent of ribosome; translation IPR012606; IPR000589; IPR023029; IPR009068; 40S ribosomal protein S13 Rps13 Rattus norvegicus (Rat) TR7916_c1_g1_i1 P02212 GLB1_ANABR 1.00E-12 GO:0005737; GO:0020037; GO:0005506; GO:0019825; GO:0005344 cytoplasm; heme binding; iron ion binding; oxygen binding; oxygen transporter activity IPR000971; IPR009050; IPR012292; Globin-1 (Globin I) (HbI) Anadara broughtonii (Blood clam) (Scapharca broughtonii) TR7917_c0_g1_i1 Q61493 DPOLZ_MOUSE 5.00E-22 GO:0051539; GO:0003677; GO:0006260; GO:0003887; GO:0005694; GO:0046872; GO:0000166; GO:0005634; GO:0019985; GO:0016035 "4 iron, 4 sulfur cluster binding; DNA binding; DNA replication; DNA-directed DNA polymerase activity; chromosome; metal ion binding; nucleotide binding; nucleus; translesion synthesis; zeta DNA polymerase complex" IPR006172; IPR017964; IPR006133; IPR006134; IPR023211; IPR012337; IPR025687; DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (Seizure-related protein 4) Rev3l Polz Sez4 Mus musculus (Mouse) TR7918_c1_g1_i1 Q63164 DYH1_RAT 8.00E-19 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR026975; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 1, axonemal (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1)" Dnah1 Dlp1 Rattus norvegicus (Rat) TR7940_c0_g1_i1 Q6NSJ0 K1161_HUMAN 4.00E-18 GO:0005975; GO:0004553; GO:0016021; GO:0031965; GO:0043568; GO:0051897; GO:0048741 "carbohydrate metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds; integral to membrane; nuclear membrane; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of protein kinase B signaling cascade; skeletal muscle fiber development" IPR013785; IPR000322; IPR017853; Uncharacterized family 31 glucosidase KIAA1161 (EC 3.2.1.-) KIAA1161 Homo sapiens (Human) TR7944_c1_g1_i1 Q6VNB8 WDFY3_MOUSE 5.00E-21 GO:0005545; GO:0005776; GO:0003831; GO:0005737; GO:0019898; GO:0046872; GO:0005635 "1-phosphatidylinositol binding; autophagic vacuole; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; cytoplasm; extrinsic to membrane; metal ion binding; nuclear envelope" IPR011989; IPR016024; IPR000409; IPR008985; IPR023362; IPR015943; IPR001680; IPR019775; IPR017986; IPR000306; IPR017455; IPR011011; IPR013083; "WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1)" Wdfy3 Mus musculus (Mouse) TR7945_c0_g1_i1 Q91X60 ACHA2_MOUSE 6.00E-18 GO:0015464; GO:0004889; GO:0005892; GO:0030054; GO:0071944; GO:0045211 acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; cell junction; cell periphery; postsynaptic membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-2 Chrna2 Mus musculus (Mouse) TR7946_c2_g1_i1 Q99715 COCA1_HUMAN 1.00E-09 GO:0007155; GO:0030574; GO:0030199; GO:0005595; GO:0005788; GO:0022617; GO:0030020; GO:0005615; GO:0070062; GO:0001501 cell adhesion; collagen catabolic process; collagen fibril organization; collagen type XII; endoplasmic reticulum lumen; extracellular matrix disassembly; extracellular matrix structural constituent conferring tensile strength; extracellular space; extracellular vesicular exosome; skeletal system development IPR008160; IPR008985; IPR013320; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) TR7955_c0_g1_i1 P35441 TSP1_MOUSE 5.00E-28 GO:0048266; GO:0048514; GO:0005509; GO:0007155; GO:0003197; GO:0050840; GO:0005615; GO:0003417; GO:0008201; GO:0006954; GO:0016525; GO:0003151; GO:0010811; GO:0010759; GO:0030511; GO:0034976; GO:0016529 behavioral response to pain; blood vessel morphogenesis; calcium ion binding; cell adhesion; endocardial cushion development; extracellular matrix binding; extracellular space; growth plate cartilage development; heparin binding; inflammatory response; negative regulation of angiogenesis; outflow tract morphogenesis; positive regulation of cell-substrate adhesion; positive regulation of macrophage chemotaxis; positive regulation of transforming growth factor beta receptor signaling pathway; response to endoplasmic reticulum stress; sarcoplasmic reticulum IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR001791; IPR000884; IPR003367; IPR017897; IPR008859; IPR001007; Thrombospondin-1 Thbs1 Tsp1 Mus musculus (Mouse) TR7957_c0_g1_i1 Q5DRD7 PCDBC_PANTR 1.00E-16 GO:0005509; GO:0007156; GO:0016021; GO:0005886 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR013164; Protocadherin beta-12 (PCDH-beta-12) PCDHB12 Pan troglodytes (Chimpanzee) TR7958_c0_g1_i1 Q6Q311 RS25_SHEEP 3.00E-18 GO:0005840 ribosome IPR004977; 40S ribosomal protein S25 RPS25 Ovis aries (Sheep) TR7962_c0_g1_i1 O01393 UNC9_CAEEL 1.00E-27 GO:0005921; GO:0055077; GO:0016021; GO:0034220; GO:0005886 gap junction; gap junction hemi-channel activity; integral to membrane; ion transmembrane transport; plasma membrane IPR000990; Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans TR7967_c0_g1_i1 Q8T8R1 Y3800_DROME 4.00E-11 GO:0003676; GO:0008270 nucleic acid binding; zinc ion binding IPR001878; CCHC-type zinc finger protein CG3800 CG3800 Drosophila melanogaster (Fruit fly) TR797_c0_g1_i1 Q9XZP2 CALM2_BRAFL 4.00E-14 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin-2 (CaM 2) CAM2 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR7976_c0_g1_i1 Q7JQD3 GELS1_LUMTE 4.00E-35 GO:0003779; GO:0051693; GO:0030043; GO:0030041; GO:0051014; GO:0045010; GO:0005509; GO:0005737; GO:0005856; GO:0007275 actin binding; actin filament capping; actin filament fragmentation; actin filament polymerization; actin filament severing; actin nucleation; calcium ion binding; cytoplasm; cytoskeleton; multicellular organismal development IPR007123; IPR007122; Gelsolin-like protein 1 (Actin-modulator) (EWAM) (EWAM-P1) AM Lumbricus terrestris (Common earthworm) TR798_c0_g1_i1 O60344 ECE2_HUMAN 9.00E-29 GO:0000139; GO:0007420; GO:0010002; GO:0007267; GO:0030659; GO:0016021; GO:0046872; GO:0004222; GO:0008168; GO:0016486; GO:0006508 Golgi membrane; brain development; cardioblast differentiation; cell-cell signaling; cytoplasmic vesicle membrane; integral to membrane; metal ion binding; metalloendopeptidase activity; methyltransferase activity; peptide hormone processing; proteolysis IPR024079; IPR013216; IPR000718; IPR018497; IPR008753; Endothelin-converting enzyme 2 (ECE-2) [Includes: Methyltransferase-like region (EC 2.1.1.-); Endothelin-converting enzyme 2 region (EC 3.4.24.71)] ECE2 KIAA0604 UNQ403/PRO740 Homo sapiens (Human) TR7993_c0_g1_i1 P11654 PO210_RAT 6.00E-69 GO:0005789; GO:0051028; GO:0031965; GO:0005643; GO:0046983; GO:0015031; GO:0017056 endoplasmic reticulum membrane; mRNA transport; nuclear membrane; nuclear pore; protein dimerization activity; protein transport; structural constituent of nuclear pore IPR003343; IPR008964; Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) Nup210 Gp210 Pom210 Rattus norvegicus (Rat) TR7994_c1_g1_i1 Q9Z2V9 CCNI_MOUSE 7.00E-25 GO:0016538; GO:0051726 cyclin-dependent protein serine/threonine kinase regulator activity; regulation of cell cycle IPR013763; IPR006671; Cyclin-I Ccni Mus musculus (Mouse) TR8003_c0_g1_i1 Q9YI37 SUCB1_COLLI 5.00E-36 GO:0005524; GO:0046872; GO:0005739; GO:0004775; GO:0006099 ATP binding; metal ion binding; mitochondrion; succinate-CoA ligase (ADP-forming) activity; tricarboxylic acid cycle IPR011761; IPR013650; IPR013815; IPR013816; IPR005811; IPR017866; IPR005809; IPR016102; Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. "Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA) (Fragment)" SUCLA2 Columba livia (Domestic pigeon) TR8006_c0_g1_i1 P30975 TLR2_DROME 2.00E-22 GO:0005887; GO:0004995 integral to plasma membrane; tachykinin receptor activity IPR000276; IPR017452; IPR001681; Tachykinin-like peptides receptor 99D (dTKR) Takr99D CG7887 Drosophila melanogaster (Fruit fly) TR8007_c0_g1_i1 Q9Z2G9 HTAI2_MOUSE 7.00E-29 GO:0001525; GO:0006915; GO:0030154; GO:0005737; GO:0005635; GO:0051170; GO:0016491; GO:0045765 angiogenesis; apoptotic process; cell differentiation; cytoplasm; nuclear envelope; nuclear import; oxidoreductase activity; regulation of angiogenesis IPR016040 Oxidoreductase HTATIP2 (EC 1.1.1.-) Htatip2 Cc3 Tip30 Mus musculus (Mouse) TR8018_c0_g1_i1 Q99NH0 ANR17_MOUSE 1.00E-07 GO:0003723; GO:0001955; GO:0005737; GO:0007492; GO:0051151; GO:0005634 RNA binding; blood vessel maturation; cytoplasm; endoderm development; negative regulation of smooth muscle cell differentiation; nucleus IPR002110; IPR020683; IPR004087; IPR004088; Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) TR8028_c0_g1_i1 Q9P225 DYH2_HUMAN 2.00E-35 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR026976; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 2, axonemal (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2) (Dynein heavy chain domain-containing protein 3)" DNAH2 DNAHC2 DNHD3 KIAA1503 Homo sapiens (Human) TR8028_c1_g1_i1 Q9C0G6 DYH6_HUMAN 3.00E-19 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 6, axonemal (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6)" DNAH6 DNAHC6 DNHL1 HL2 KIAA1697 Homo sapiens (Human) TR8034_c0_g1_i1 Q827H4 MSOX_STRAW 3.00E-10 GO:0008442; GO:0005737; GO:0008115; GO:0046653; GO:0006573 3-hydroxyisobutyrate dehydrogenase activity; cytoplasm; sarcosine oxidase activity; tetrahydrofolate metabolic process; valine metabolic process IPR002204; IPR006076; IPR006281; Monomeric sarcosine oxidase (MSOX) (EC 1.5.3.1) soxA solA SAV_6950 Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680) TR8036_c0_g1_i1 Q6NRC9 LRCC1_XENLA 2.00E-21 GO:0051301; GO:0005814; GO:0007067 cell division; centriole; mitosis IPR001611; IPR025875; Leucine-rich repeat and coiled-coil domain-containing protein 1 lrrcc1 Xenopus laevis (African clawed frog) TR8047_c1_g1_i1 Q97J66 Y1420_CLOAB 1.00E-06 GO:0006725; GO:0008198; GO:0055114; GO:0016491 cellular aromatic compound metabolic process; ferrous iron binding; oxidation-reduction process; oxidoreductase activity IPR023473; IPR002733; IPR027485; IPR027623; IPR002737; IPR023472; IPR004183; Protein CA_C1420 CA_C1420 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) TR8048_c0_g1_i1 P40009 YND1_YEAST 3.00E-18 GO:0005524; GO:0000139; GO:0016021; GO:0017110; GO:0017111; GO:0006486; GO:0006665 ATP binding; Golgi membrane; integral to membrane; nucleoside-diphosphatase activity; nucleoside-triphosphatase activity; protein glycosylation; sphingolipid metabolic process IPR000407; Protein modification; protein glycosylation. Golgi apyrase (EC 3.6.1.5) (ATP-diphosphatase) (ATP-diphosphohydrolase) (Adenosine diphosphatase) (ADPase) (Golgi nucleoside diphosphatase) (Yeast nucleoside diphosphatase 1) YND1 YER005W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR8049_c0_g1_i1 P98061 NAS28_CAEEL 2.00E-08 GO:0005576; GO:0004222; GO:0006508; GO:0008270 extracellular region; metalloendopeptidase activity; proteolysis; zinc ion binding IPR000859; IPR024079; IPR001506; IPR017050; IPR006026; Zinc metalloproteinase nas-28 (EC 3.4.24.21) (Nematode astacin 28) nas-28 F42A10.8 Caenorhabditis elegans TR8059_c0_g1_i1 Q8VHK2 CSKI1_RAT 1.00E-08 GO:0005737; GO:0019904; GO:0007165 Q9NYB9 cytoplasm; protein domain specific binding; signal transduction IPR002110; IPR020683; IPR027013; IPR027001; IPR001660; IPR013761; IPR021129; IPR011511; IPR001452; Caskin-1 (CASK-interacting protein 1) Caskin1 Rattus norvegicus (Rat) TR8059_c2_g1_i1 Q86U10 LPP60_HUMAN 5.00E-10 GO:0003847; GO:0004067; GO:0006528; GO:0016042; GO:0004622; GO:0006644 1-alkyl-2-acetylglycerophosphocholine esterase activity; asparaginase activity; asparagine metabolic process; lipid catabolic process; lysophospholipase activity; phospholipid metabolic process IPR002110; IPR020683; IPR006033; IPR006034; IPR027475; IPR027473; IPR027474; 60 kDa lysophospholipase (EC 3.1.1.5) [Includes: L-asparaginase (EC 3.5.1.1) (L-asparagine amidohydrolase); Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47)] ASPG C14orf76 Homo sapiens (Human) TR8065_c0_g1_i1 Q5VYJ5 CJ112_HUMAN 4.00E-12 GO:0016021 integral to membrane IPR008985; IPR023415; IPR002172; IPR000998; MAM and LDL-receptor class A domain-containing protein C10orf112 C10orf112 Homo sapiens (Human) TR807_c0_g1_i1 Q54KD0 Y7407_DICDI 4.00E-15 GO:0017111; GO:0000166 nucleoside-triphosphatase activity; nucleotide binding IPR003593; IPR025139; IPR014756; IPR027417; IPR013026; IPR011990; IPR019734; TPR repeat-containing protein DDB_G0287407 DDB_G0287407 Dictyostelium discoideum (Slime mold) TR8078_c1_g1_i1 Q9UQ53 MGT4B_HUMAN 3.00E-12 GO:0000139; GO:0006491; GO:0008454; GO:0016021; GO:0046872; GO:0043687; GO:0018279 "Golgi membrane; N-glycan processing; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; integral to membrane; metal ion binding; post-translational protein modification; protein N-linked glycosylation via asparagine" IPR006759; Protein modification; protein glycosylation. "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb) (GlcNAc-T IVb) (GnT-IVb) (N-acetylglucosaminyltransferase IVb) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb)" MGAT4B UNQ906/PRO1927 Homo sapiens (Human) TR8083_c0_g1_i1 P31596 EAA2_RAT 3.00E-12 GO:0043198; GO:0043197; GO:0005314; GO:0016021; GO:0006836; GO:0042734; GO:0017153 dendritic shaft; dendritic spine; high-affinity glutamate transmembrane transporter activity; integral to membrane; neurotransmitter transport; presynaptic membrane; sodium:dicarboxylate symporter activity IPR001991; IPR018107; Excitatory amino acid transporter 2 (GLT-1) (Sodium-dependent glutamate/aspartate transporter 2) (GLUT-R) (Solute carrier family 1 member 2) Slc1a2 Eaat2 Glt1 Rattus norvegicus (Rat) TR8088_c0_g1_i1 Q9CPW7 ZMAT2_MOUSE 1.00E-31 GO:0003677; GO:0005634; GO:0008270 DNA binding; nucleus; zinc ion binding IPR015880; IPR022755; IPR003604; Zinc finger matrin-type protein 2 Zmat2 Mus musculus (Mouse) TR8097_c1_g1_i1 Q6P9U1 NUD22_RAT 8.00E-37 GO:0016787 hydrolase activity IPR000086; Nucleoside diphosphate-linked moiety X motif 22 (Nudix motif 22) Nudt22 Rattus norvegicus (Rat) TR8098_c0_g1_i1 Q9I929 FUCL3_ANGJA 3.00E-07 GO:0005509; GO:0007155; GO:0005615; GO:0042806; GO:0010185; GO:0001868 "calcium ion binding; cell adhesion; extracellular space; fucose binding; regulation of cellular defense response; regulation of complement activation, lectin pathway" IPR000421; IPR006585; IPR008979; Fucolectin-3 Anguilla japonica (Japanese eel) TR8102_c0_g1_i1 Q8TC21 ZN596_HUMAN 6.00E-27 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 596 ZNF596 Homo sapiens (Human) TR811_c0_g1_i1 Q96L42 KCNH8_HUMAN 4.00E-40 GO:0005887; GO:0000155; GO:0042391; GO:0023014; GO:0007268; GO:0005249 integral to plasma membrane; phosphorelay sensor kinase activity; regulation of membrane potential; signal transduction by phosphorylation; synaptic transmission; voltage-gated potassium channel activity IPR018490; IPR000595; IPR005821; IPR003938; IPR003950; IPR001610; IPR000014; IPR000700; IPR014710; Potassium voltage-gated channel subfamily H member 8 (ELK1) (hElk1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (Voltage-gated potassium channel subunit Kv12.1) KCNH8 Homo sapiens (Human) TR8111_c1_g1_i1 Q8K1R7 NEK9_MOUSE 4.00E-21 GO:0005524; GO:0051301; GO:0046872; GO:0005739; GO:0007067; GO:0005634; GO:0019901; GO:0004674 ATP binding; cell division; metal ion binding; mitochondrion; mitosis; nucleus; protein kinase binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR009091; IPR000408; IPR002290; IPR008271; Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) Nek9 Nercc Mus musculus (Mouse) TR8123_c0_g1_i1 Q9NVE5 UBP40_HUMAN 1.00E-11 GO:0008234; GO:0004221; GO:0006511 cysteine-type peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR018200; IPR001394; Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.4.19.12) (Deubiquitinating enzyme 40) (Ubiquitin thioesterase 40) (Ubiquitin-specific-processing protease 40) USP40 Homo sapiens (Human) TR8134_c0_g1_i1 Q24266 BTD_DROME 1.00E-14 GO:0003705; GO:0035288; GO:0007376; GO:0007480; GO:0046872; GO:0000122; GO:0005634; GO:0045944; GO:0035289; GO:0043565 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; anterior head segmentation; cephalic furrow formation; imaginal disc-derived leg morphogenesis; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of transcription from RNA polymerase II promoter; posterior head segmentation; sequence-specific DNA binding IPR007087; IPR015880; IPR013087; Transcription factor btd (Protein buttonhead) btd CG12653 Drosophila melanogaster (Fruit fly) TR8134_c1_g1_i1 O60304 ZN500_HUMAN 9.00E-34 GO:0003677; GO:0046872; GO:0005634; GO:0003700; GO:0006351 "DNA binding; metal ion binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR001909; IPR008916; IPR003309; IPR007087; IPR015880; IPR013087; Zinc finger protein 500 (Zinc finger protein with KRAB and SCAN domains 18) ZNF500 KIAA0557 ZKSCAN18 Homo sapiens (Human) TR8135_c1_g1_i1 D3ZAT9 FAXC_RAT 6.00E-32 GO:0016021 integral to membrane IPR026928; IPR010987; IPR012336; Failed axon connections homolog Faxc Rattus norvegicus (Rat) TR8145_c0_g1_i1 O57579 AMPN_CHICK 2.00E-06 GO:0004177; GO:0016021; GO:0008237; GO:0005886; GO:0006508; GO:0008270 aminopeptidase activity; integral to membrane; metallopeptidase activity; plasma membrane; proteolysis; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (EC 3.4.11.2) (Aminopeptidase Ey) (EC 3.4.11.20) ANPEP APDE Gallus gallus (Chicken) TR8147_c0_g1_i1 Q4UKX2 Y950_RICFE 9.00E-07 GO:0006541; GO:0016787 glutamine metabolic process; hydrolase activity IPR002110; IPR020683; IPR017926; IPR011697; Putative ankyrin repeat protein RF_0950 RF_0950 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) TR8163_c0_g1_i1 Q25414 5HTR_LYMST 2.00E-07 GO:0004930; GO:0016021; GO:0005886 G-protein coupled receptor activity; integral to membrane; plasma membrane IPR000276; IPR017452; 5-hydroxytryptamine receptor (5-HT receptor) (Serotonin receptor) Lymnaea stagnalis (Great pond snail) TR8167_c1_g2_i1 Q8NFA0 UBP32_HUMAN 9.00E-10 GO:0005794; GO:0005509; GO:0008234; GO:0016020; GO:0016579; GO:0004221; GO:0006511 Golgi apparatus; calcium ion binding; cysteine-type peptidase activity; membrane; protein deubiquitination; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process IPR011992; IPR018247; IPR002048; IPR006615; IPR018200; IPR001394; IPR001125; IPR028135; Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) USP32 USP10 Homo sapiens (Human) TR8175_c0_g5_i1 Q4PM47 RS29_IXOSC 6.00E-30 GO:0046872; GO:0005840; GO:0003735; GO:0006412 metal ion binding; ribosome; structural constituent of ribosome; translation IPR001209; IPR018271; 40S ribosomal protein S29 RpS29 Ixodes scapularis (Black-legged tick) (Deer tick) TR8176_c0_g1_i1 Q9BXI9 C1QT6_HUMAN 1.00E-06 GO:0005581; GO:0005615; GO:0070208 collagen; extracellular space; protein heterotrimerization IPR001073; IPR008160; IPR008983; Complement C1q tumor necrosis factor-related protein 6 C1QTNF6 CTRP6 UNQ581/PRO1151 Homo sapiens (Human) TR8179_c0_g1_i1 Q4G0N4 NAKD1_HUMAN 5.00E-18 GO:0005524; GO:0019674; GO:0003951; GO:0006741; GO:0005739; GO:0042803 ATP binding; NAD metabolic process; NAD+ kinase activity; NADP biosynthetic process; mitochondrion; protein homodimerization activity IPR012355; IPR017438; IPR016064; IPR017437; IPR002504; "NAD kinase 2, mitochondrial (EC 2.7.1.23) (Mitochondrial NAD kinase) (NAD kinase domain-containing protein 1, mitochondrial)" NADK2 C5orf33 MNADK NADKD1 Homo sapiens (Human) TR8180_c0_g1_i1 Q98SH3 ADRM1_CHICK 2.00E-48 GO:0005737; GO:0061133; GO:0005634; GO:0043248; GO:0000502 cytoplasm; endopeptidase activator activity; nucleus; proteasome assembly; proteasome complex IPR006773; Proteasomal ubiquitin receptor ADRM1 (Adhesion-regulating molecule 1) (ARM-1) ADRM1 Gallus gallus (Chicken) TR8188_c0_g1_i1 Q9CR88 RT14_MOUSE 2.00E-06 GO:0005763; GO:0031965; GO:0003735; GO:0006412 mitochondrial small ribosomal subunit; nuclear membrane; structural constituent of ribosome; translation IPR001209; "28S ribosomal protein S14, mitochondrial (MRP-S14) (S14mt)" Mrps14 Mus musculus (Mouse) TR8190_c0_g1_i1 Q9BQ49 CS042_HUMAN 2.00E-27 GO:0016021 integral to membrane Small integral membrane protein 7 SMIM7 C19orf42 Homo sapiens (Human) TR8193_c0_g1_i1 Q5F3I6 TM104_CHICK 3.00E-47 GO:0016021 integral to membrane IPR013057; Transmembrane protein 104 TMEM104 RCJMB04_15p16 Gallus gallus (Chicken) TR8202_c0_g1_i1 Q96MM6 HS12B_HUMAN 9.00E-20 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR8216_c1_g1_i1 Q5R5M5 ENPP3_PONAB 5.00E-48 GO:0035529; GO:0005576; GO:0006955; GO:0016021; GO:0046872; GO:0003676; GO:0004528; GO:0030247; GO:0005044 NADH pyrophosphatase activity; extracellular region; immune response; integral to membrane; metal ion binding; nucleic acid binding; phosphodiesterase I activity; polysaccharide binding; scavenger receptor activity IPR017849; IPR017850; IPR001604; IPR024873; IPR020821; IPR002591; IPR001212; Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (E-NPP 3) (Phosphodiesterase I beta) (PD-Ibeta) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (CD antigen CD203c) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9)] ENPP3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR8216_c2_g1_i1 P25353 NPP1_YEAST 4.00E-11 GO:0035529; GO:0016036; GO:0016021; GO:0009141; GO:0017111; GO:0047429; GO:0004551; GO:0004528 NADH pyrophosphatase activity; cellular response to phosphate starvation; integral to membrane; nucleoside triphosphate metabolic process; nucleoside-triphosphatase activity; nucleoside-triphosphate diphosphatase activity; nucleotide diphosphatase activity; phosphodiesterase I activity IPR017849; IPR017850; IPR024873; IPR002591; Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) [Includes: Alkaline phosphodiesterase 1 (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9)] NPP1 YCR026C YCR246 YCR26C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR8218_c0_g1_i1 Q8NAG6 ANKL1_HUMAN 1.00E-14 IPR002110; IPR020683; IPR000305; IPR011015; IPR003887; Ankyrin repeat and LEM domain-containing protein 1 (Ankyrin repeat domain-containing protein 41) (LEM-domain containing protein 3) ANKLE1 ANKRD41 LEM3 Homo sapiens (Human) TR8218_c0_g2_i1 P16157 ANK1_HUMAN 9.00E-11 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR8234_c0_g1_i1 Q96BD0 SO4A1_HUMAN 3.00E-14 GO:0016021; GO:0005886; GO:0043252; GO:0055085; GO:0005215 integral to membrane; plasma membrane; sodium-independent organic anion transport; transmembrane transport; transporter activity IPR002350; IPR020846; IPR016196; IPR004156; Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) SLCO4A1 OATP1 OATP4A1 OATPE SLC21A12 Homo sapiens (Human) TR8240_c0_g1_i1 Q9UDV7 ZN282_HUMAN 9.00E-09 GO:0003677; GO:0045892; GO:0005634; GO:0006351; GO:0008270 "DNA binding; negative regulation of transcription, DNA-dependent; nucleus; transcription, DNA-dependent; zinc ion binding" IPR022137; IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1) ZNF282 HUB1 Homo sapiens (Human) TR8244_c0_g2_i1 C8YR32 LOXH1_MOUSE 1.00E-07 GO:0005262; GO:0050982; GO:0016020; GO:0007605; GO:0032420 calcium channel activity; detection of mechanical stimulus; membrane; sensory perception of sound; stereocilium IPR008976; IPR001024; Lipoxygenase homology domain-containing protein 1 Loxhd1 Mus musculus (Mouse) TR8246_c0_g1_i1 Q1LXI5 RM54_DANRE 9.00E-13 GO:0005739; GO:0005840 mitochondrion; ribosome IPR013870; "39S ribosomal protein L54, mitochondrial (L54mt) (MRP-L54)" mrpl54 si:dkeyp-70f9.5 Danio rerio (Zebrafish) (Brachydanio rerio) TR8250_c0_g1_i1 P07338 CTRB1_RAT 1.00E-14 GO:0007586; GO:0005615; GO:0005764; GO:0043065; GO:0030163; GO:0006508; GO:0034097; GO:0032094; GO:0007584; GO:0043434; GO:0009636; GO:0004252 digestion; extracellular space; lysosome; positive regulation of apoptotic process; protein catabolic process; proteolysis; response to cytokine stimulus; response to food; response to nutrient; response to peptide hormone stimulus; response to toxic substance; serine-type endopeptidase activity IPR001254; IPR018114; IPR001314; IPR009003; Chymotrypsinogen B (EC 3.4.21.1) [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C] Ctrb1 Ctrb Rattus norvegicus (Rat) TR8258_c0_g1_i1 Q9TSZ3 KCNH2_CANFA 6.00E-36 GO:0016021; GO:0000155; GO:0023014; GO:0005249 integral to membrane; phosphorelay sensor kinase activity; signal transduction by phosphorylation; voltage-gated potassium channel activity IPR018490; IPR000595; IPR005821; IPR003938; IPR003967; IPR001610; IPR000014; IPR000700; IPR014710; Potassium voltage-gated channel subfamily H member 2 (Ether-a-go-go-related gene potassium channel 1) (DERG) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (c-ERG) (Voltage-gated potassium channel subunit Kv11.1) KCNH2 CERG ERG Canis familiaris (Dog) (Canis lupus familiaris) TR8261_c1_g1_i1 Q52KR2 LRIG2_MOUSE 7.00E-10 GO:0005737; GO:0016021; GO:0005886 cytoplasm; integral to membrane; plasma membrane IPR000483; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR001611; IPR003591; Leucine-rich repeats and immunoglobulin-like domains protein 2 (LIG-2) Lrig2 Kiaa0806 Mus musculus (Mouse) TR8263_c0_g1_i1 Q5ZL57 COPD_CHICK 5.00E-23 GO:0030126; GO:0008344; GO:0021691; GO:0030131; GO:0005783; GO:0006886; GO:0043473; GO:0006890 "COPI vesicle coat; adult locomotory behavior; cerebellar Purkinje cell layer maturation; clathrin adaptor complex; endoplasmic reticulum; intracellular protein transport; pigmentation; retrograde vesicle-mediated transport, Golgi to ER" IPR022775; IPR008968; IPR027059; IPR011012; Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) ARCN1 COPD RCJMB04_7j3 Gallus gallus (Chicken) TR8269_c2_g1_i1 Q24048 ATPB2_DROME 2.00E-39 GO:0006812; GO:0061343; GO:0060857; GO:0006813; GO:0035158; GO:0035159; GO:0007605; GO:0005918; GO:0019991; GO:0006814; GO:0005890 "cation transport; cell adhesion involved in heart morphogenesis; establishment of glial blood-brain barrier; potassium ion transport; regulation of tube diameter, open tracheal system; regulation of tube length, open tracheal system; sensory perception of sound; septate junction; septate junction assembly; sodium ion transport; sodium:potassium-exchanging ATPase complex" IPR000402; Sodium/potassium-transporting ATPase subunit beta-2 (Protein nervana 2) (Sodium/potassium-dependent ATPase subunit beta-2) nrv2 CG9261 Drosophila melanogaster (Fruit fly) TR8271_c1_g1_i1 Q9SMH3 DYH1A_CHLRE 7.00E-14 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026982; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein-1-alpha heavy chain, flagellar inner arm I1 complex (1-alpha DHC) (Dynein-1, subspecies f)" DHC1 IDA1 PF9 Chlamydomonas reinhardtii (Chlamydomonas smithii) TR8271_c2_g1_i1 P23098 DYHC_TRIGR 7.00E-35 GO:0005524; GO:0006200; GO:0016887; GO:0030030; GO:0005929; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cell projection organization; cilium; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein beta chain, ciliary" Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla) TR8278_c0_g2_i1 Q9CYL5 GAPR1_MOUSE 1.00E-14 GO:0000139; GO:0005576 Golgi membrane; extracellular region IPR001283; IPR018244; IPR014044; Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) Glipr2 Gapr1 Mus musculus (Mouse) TR8282_c0_g1_i1 Q8WWY8 LIPH_HUMAN 2.00E-09 GO:0005615; GO:0008201; GO:0016042; GO:0004620; GO:0005886 extracellular space; heparin binding; lipid catabolic process; phospholipase activity; plasma membrane IPR000734; IPR013818; IPR016272; Lipase member H (LIPH) (EC 3.1.1.-) (LPD lipase-related protein) (Membrane-associated phosphatidic acid-selective phospholipase A1-alpha) (mPA-PLA1 alpha) (Phospholipase A1 member B) LIPH LPDLR MPAPLA1 PLA1B Homo sapiens (Human) TR8287_c0_g1_i1 Q8NHV1 GIMA7_HUMAN 7.00E-13 GO:0005525; GO:0003924; GO:0005811 GTP binding; GTPase activity; lipid particle IPR006703; IPR027417; GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) TR8287_c0_g2_i1 Q8K3K9 GIMA4_RAT 3.00E-10 GO:0005525; GO:0005829 GTP binding; cytosol IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) TR8289_c0_g1_i1 Q80YX1 TENA_MOUSE 4.00E-15 GO:0005604; GO:0007155; GO:0005615; GO:0005614; GO:0060739; GO:0007528; GO:0014012; GO:0008284; GO:0010628; GO:0060740; GO:0045545 basement membrane; cell adhesion; extracellular space; interstitial matrix; mesenchymal-epithelial cell signaling involved in prostate gland development; neuromuscular junction development; peripheral nervous system axon regeneration; positive regulation of cell proliferation; positive regulation of gene expression; prostate gland epithelium morphogenesis; syndecan binding IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin (TN) (Hexabrachion) (Tenascin-C) (TN-C) Tnc Hxb Mus musculus (Mouse) TR8290_c0_g1_i1 Q5URB8 YR841_MIMIV 3.00E-11 IPR002110; IPR020683; Putative ankyrin repeat protein R841 MIMI_R841 Acanthamoeba polyphaga mimivirus (APMV) TR8291_c0_g1_i1 Q9HCS2 CP4FC_HUMAN 1.00E-142 GO:0018685; GO:0016324; GO:0008392; GO:0070330; GO:0017144; GO:0005789; GO:0019373; GO:0020037; GO:0016021; GO:0005506; GO:0050051; GO:0030195; GO:0003095; GO:0003091; GO:0055078; GO:0000038; GO:0042360; GO:0042371; GO:0047057; GO:0006805 alkane 1-monooxygenase activity; apical plasma membrane; arachidonic acid epoxygenase activity; aromatase activity; drug metabolic process; endoplasmic reticulum membrane; epoxygenase P450 pathway; heme binding; integral to membrane; iron ion binding; leukotriene-B4 20-monooxygenase activity; negative regulation of blood coagulation; pressure natriuresis; renal water homeostasis; sodium ion homeostasis; very long-chain fatty acid metabolic process; vitamin E metabolic process; vitamin K biosynthetic process; vitamin-K-epoxide reductase (warfarin-sensitive) activity; xenobiotic metabolic process IPR001128; IPR017972; IPR002401; Cytochrome P450 4F12 (EC 1.14.14.1) (CYPIVF12) CYP4F12 UNQ568/PRO1129 Homo sapiens (Human) TR8294_c1_g1_i1 Q9U5N1 VATC_MANSE 4.00E-37 GO:0015991; GO:0015078; GO:0033180 "ATP hydrolysis coupled proton transport; hydrogen ion transmembrane transporter activity; proton-transporting V-type ATPase, V1 domain" IPR004907; V-type proton ATPase subunit C (V-ATPase subunit C) (Vacuolar proton pump subunit C) Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) TR8297_c0_g1_i1 Q5RJZ1 RTEL1_RAT 4.00E-12 GO:0051539; GO:0005524; GO:0004003; GO:0003677; GO:0006281; GO:0046872; GO:0005634; GO:0010569; GO:0000723 "4 iron, 4 sulfur cluster binding; ATP binding; ATP-dependent DNA helicase activity; DNA binding; DNA repair; metal ion binding; nucleus; regulation of double-strand break repair via homologous recombination; telomere maintenance" IPR006555; IPR010614; IPR013020; IPR014013; IPR006554; IPR006935; IPR027417; Regulator of telomere elongation helicase 1 (EC 3.6.4.12) Rtel1 Rattus norvegicus (Rat) TR830_c0_g1_i1 B2RRL2 JERKL_MOUSE 1.00E-06 GO:0003677; GO:0005634 DNA binding; nucleus IPR004875; IPR009057; IPR006600; IPR007889; Jerky protein homolog-like Jrkl Mus musculus (Mouse) TR830_c0_g2_i1 Q9P215 POGK_HUMAN 4.00E-08 GO:0003677; GO:0007275; GO:0005634; GO:0006355 P08238 "DNA binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent" IPR018586; IPR004875; IPR009057; IPR006600; IPR001909; Pogo transposable element with KRAB domain POGK KIAA1513 LST003 SLTP003 Homo sapiens (Human) TR8307_c0_g1_i1 Q91048 PTK7_CHICK 7.00E-21 GO:0005524; GO:0016055; GO:0007155; GO:0016021; GO:0018108; GO:0004713 ATP binding; Wnt receptor signaling pathway; cell adhesion; integral to membrane; peptidyl-tyrosine phosphorylation; protein tyrosine kinase activity IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR001245; IPR008266; IPR020635; Inactive tyrosine-protein kinase 7 (Kinase-like protein) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7) PTK7 KLG Gallus gallus (Chicken) TR8309_c0_g1_i1 Q9Y210 TRPC6_HUMAN 3.00E-18 GO:0007411; GO:0006812; GO:0007204; GO:0070679; GO:0016021; GO:0005886; GO:0030168; GO:0051928; GO:0032414; GO:0036057; GO:0015279 P20591 "axon guidance; cation transport; elevation of cytosolic calcium ion concentration; inositol 1,4,5 trisphosphate binding; integral to membrane; plasma membrane; platelet activation; positive regulation of calcium ion transport; positive regulation of ion transmembrane transporter activity; slit diaphragm; store-operated calcium channel activity" IPR002110; IPR020683; IPR005821; IPR004729; IPR013555; IPR005462; IPR002153; Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) TRPC6 TRP6 Homo sapiens (Human) TR8313_c0_g1_i1 O43854 EDIL3_HUMAN 5.00E-21 GO:0005509; GO:0007155; GO:0070062; GO:0005178; GO:0007275; GO:0010811 calcium ion binding; cell adhesion; extracellular vesicular exosome; integrin binding; multicellular organismal development; positive regulation of cell-substrate adhesion IPR000421; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR008979; EGF-like repeat and discoidin I-like domain-containing protein 3 (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1) EDIL3 DEL1 Homo sapiens (Human) TR8317_c0_g1_i1 Q8TD08 MK15_HUMAN 7.00E-72 GO:0005524; GO:0004707; GO:0017124; GO:0005576; GO:0005622; GO:0008156; GO:0000122; GO:0005634; GO:0045732; GO:0001934; GO:0031398; GO:0046777; GO:0032355 ATP binding; MAP kinase activity; SH3 domain binding; extracellular region; intracellular; negative regulation of DNA replication; negative regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of protein catabolic process; positive regulation of protein phosphorylation; positive regulation of protein ubiquitination; protein autophosphorylation; response to estradiol stimulus IPR011009; IPR003527; IPR000719; IPR017441; IPR002290; Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) MAPK15 ERK7 ERK8 Homo sapiens (Human) TR8332_c0_g1_i1 Q9NX63 CHCH3_HUMAN 1.00E-06 GO:0001227; GO:0007007; GO:0008053; GO:0005743; GO:0005634; GO:0019902; GO:0032947 Q15834; P62136 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; inner mitochondrial membrane organization; mitochondrial fusion; mitochondrial inner membrane; nucleus; phosphatase binding; protein complex scaffold IPR007964; "Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial" CHCHD3 MINOS3 Homo sapiens (Human) TR8344_c1_g1_i1 Q2PZL6 FAT4_MOUSE 1.00E-14 GO:0045177; GO:0001658; GO:0005509; GO:0048565; GO:0001736; GO:0003007; GO:0007156; GO:0060122; GO:0016021; GO:0001822; GO:0043931; GO:0005886; GO:0007009 apical part of cell; branching involved in ureteric bud morphogenesis; calcium ion binding; digestive tract development; establishment of planar polarity; heart morphogenesis; homophilic cell adhesion; inner ear receptor stereocilium organization; integral to membrane; kidney development; ossification involved in bone maturation; plasma membrane; plasma membrane organization IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) Fat4 Fatj Mus musculus (Mouse) TR8345_c2_g1_i1 Q9Z0Z5 S13A3_RAT 5.00E-39 GO:0015183; GO:0015137; GO:0016021; GO:0005886; GO:0017153; GO:0015141 L-aspartate transmembrane transporter activity; citrate transmembrane transporter activity; integral to membrane; plasma membrane; sodium:dicarboxylate symporter activity; succinate transmembrane transporter activity IPR001898; Solute carrier family 13 member 3 (Na(+)/dicarboxylate cotransporter 3) (NaDC-3) (rNaDC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) Slc13a3 Nadc3 Sdct2 Rattus norvegicus (Rat) TR8351_c0_g1_i1 Q56253 TBP_THECE 1.00E-08 GO:0003677; GO:0006352; GO:0003700 "DNA binding; DNA-dependent transcription, initiation; sequence-specific DNA binding transcription factor activity" IPR012295; IPR000814; TATA-box-binding protein (Box A-binding protein) (BAP) (TATA sequence-binding protein) (TBP) (TATA-box factor) tbp Thermococcus celer TR8356_c0_g1_i1 Q9ULJ7 ANR50_HUMAN 1.00E-11 IPR002110; IPR020683; Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) TR836_c0_g1_i1 Q9QZB7 ARP10_MOUSE 2.00E-16 GO:0005737; GO:0005869; GO:0007018 P42025 cytoplasm; dynactin complex; microtubule-based movement IPR004000; IPR027127; Actin-related protein 10 (Actin-related protein 11) Actr10 Act11 Actr11 Arp11 Mus musculus (Mouse) TR8366_c0_g1_i1 Q7DFU6 YGHX_ECOLI 2.00E-17 GO:0016787 hydrolase activity IPR002925; Putative uncharacterized protein YghX yghX yghY b4658 JW5926/JW5496 b2999 b3000 Escherichia coli (strain K12) TR8371_c0_g1_i1 O43301 HS12A_HUMAN 6.00E-19 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR8375_c0_g1_i1 P42674 BP10_PARLI 6.00E-09 GO:0005938; GO:0005615; GO:0004222; GO:0048471; GO:0006508; GO:0008270 cell cortex; extracellular space; metalloendopeptidase activity; perinuclear region of cytoplasm; proteolysis; zinc ion binding IPR000859; IPR000742; IPR013032; IPR024079; IPR001506; IPR006026; IPR017369; Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) TR8387_c1_g1_i1 P31661 SC6A8_RABIT 9.00E-14 GO:0005309; GO:0005887; GO:0005328 creatine:sodium symporter activity; integral to plasma membrane; neurotransmitter:sodium symporter activity IPR000175; IPR002984; Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8) SLC6A8 Oryctolagus cuniculus (Rabbit) TR8390_c0_g1_i1 Q6NW40 RGMB_HUMAN 8.00E-08 GO:0030509; GO:0046658; GO:0007411; GO:0007155; GO:0005793; GO:0042802; GO:0045121; GO:0045893 "BMP signaling pathway; anchored to plasma membrane; axon guidance; cell adhesion; endoplasmic reticulum-Golgi intermediate compartment; identical protein binding; membrane raft; positive regulation of transcription, DNA-dependent" IPR009496; IPR010536; RGM domain family member B (DRG11-responsive axonal guidance and outgrowth of neurite) (DRAGON) RGMB Homo sapiens (Human) TR8401_c0_g1_i1 Q9HBX8 LGR6_HUMAN 7.00E-06 GO:0007186; GO:0016055; GO:0005887; GO:0090263; GO:0032588; GO:0004888 G-protein coupled receptor signaling pathway; Wnt receptor signaling pathway; integral to plasma membrane; positive regulation of canonical Wnt receptor signaling pathway; trans-Golgi network membrane; transmembrane signaling receptor activity IPR000276; IPR002131; IPR001611; IPR003591; IPR000372; Leucine-rich repeat-containing G-protein coupled receptor 6 LGR6 UNQ6427/PRO21331 VTS20631 Homo sapiens (Human) TR8403_c3_g1_i1 Q96MM6 HS12B_HUMAN 7.00E-09 GO:0005524 ATP binding Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) TR8404_c1_g1_i1 Q90YJ2 NGB_DANRE 4.00E-12 GO:0005737; GO:0020037; GO:0005506; GO:0019825; GO:0005344; GO:0043204; GO:0001666 cytoplasm; heme binding; iron ion binding; oxygen binding; oxygen transporter activity; perikaryon; response to hypoxia IPR000971; IPR009050; IPR012292; IPR001032; Neuroglobin ngb si:ch211-233n24.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR8409_c0_g1_i1 Q9QYE7 ITAD_RAT 3.00E-07 GO:0007155; GO:0008305; GO:0007229; GO:0046872 cell adhesion; integrin complex; integrin-mediated signaling pathway; metal ion binding IPR013517; IPR013519; IPR000413; IPR013649; IPR018184; IPR002035; Integrin alpha-D (CD antigen CD11d) Itgad Itgax Rattus norvegicus (Rat) TR8413_c0_g1_i1 Q5M8G4 LRC40_XENTR 3.00E-06 IPR001611; IPR003591; Leucine-rich repeat-containing protein 40 lrrc40 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR8417_c1_g1_i1 Q7LHG5 YI31B_YEAST 4.00E-29 GO:0005524; GO:0003677; GO:0015074; GO:0006310; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0005737; GO:0008233; GO:0006508; GO:0000943; GO:0004523; GO:0004540; GO:0032197; GO:0046797; GO:0008270 "ATP binding; DNA binding; DNA integration; DNA recombination; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; cytoplasm; peptidase activity; proteolysis; retrotransposon nucleocapsid; ribonuclease H activity; ribonuclease activity; transposition, RNA-mediated; viral procapsid maturation; zinc ion binding" IPR001584; IPR024650; IPR021109; IPR005162; IPR012337; IPR000477; IPR001878; Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR8418_c1_g1_i1 Q9VRJ2 FITM_DROME 5.00E-38 GO:0005789; GO:0016021; GO:0019915 O96757 endoplasmic reticulum membrane; integral to membrane; lipid storage IPR019388; FIT family protein CG10671 CG10671 Drosophila melanogaster (Fruit fly) TR8429_c0_g2_i1 Q9Y6Y1 CMTA1_HUMAN 6.00E-34 GO:0003677; GO:0005737; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cytoplasm; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002110; IPR020683; IPR005559; IPR013783; IPR014756; IPR002909; IPR000048; IPR027417; Calmodulin-binding transcription activator 1 CAMTA1 KIAA0833 MSTP023 Homo sapiens (Human) TR8431_c0_g1_i1 Q8BR93 HARB1_MOUSE 6.00E-10 GO:0005813; GO:0005737; GO:0046872; GO:0004518; GO:0090305; GO:0005634 centrosome; cytoplasm; metal ion binding; nuclease activity; nucleic acid phosphodiester bond hydrolysis; nucleus IPR026103; IPR027806; IPR026244; Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) Harbi1 Mus musculus (Mouse) TR8437_c0_g1_i1 Q8BPQ7 SGSM1_MOUSE 6.00E-06 GO:0005794; GO:0005097; GO:0032851 Golgi apparatus; Rab GTPase activator activity; positive regulation of Rab GTPase activity IPR000195; IPR004012; Small G protein signaling modulator 1 (RUN and TBC1 domain-containing protein 2) Sgsm1 Rutbc2 Mus musculus (Mouse) TR8439_c0_g2_i1 Q5XH16 NH2L1_XENLA 1.00E-58 GO:0003723; GO:0008380; GO:0006397; GO:0005730; GO:0042254; GO:0005681 RNA binding; RNA splicing; mRNA processing; nucleolus; ribosome biogenesis; spliceosomal complex IPR002415; IPR004038; IPR018492; IPR004037; NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (U4/U6.U5 tri-snRNP 15.5 kDa protein) nhp2l1 Xenopus laevis (African clawed frog) TR8454_c1_g1_i1 Q863B3 SND1_BOVIN 3.00E-45 GO:0016442; GO:0031047; GO:0042470; GO:0005739; GO:0004518; GO:0003676; GO:0090305; GO:0005634; GO:0006355; GO:0006351 "RISC complex; gene silencing by RNA; melanosome; mitochondrion; nuclease activity; nucleic acid binding; nucleic acid phosphodiester bond hydrolysis; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR016685; IPR016071; IPR002071; IPR002999; Staphylococcal nuclease domain-containing protein 1 (100 kDa coactivator) (p100 co-activator) SND1 Bos taurus (Bovine) TR8462_c0_g1_i1 Q8N0N3 BGBP_PENMO 2.00E-19 GO:0001872; GO:0005975; GO:0005576; GO:0004553; GO:0045087 "(1->3)-beta-D-glucan binding; carbohydrate metabolic process; extracellular region; hydrolase activity, hydrolyzing O-glycosyl compounds; innate immune response" IPR008985; IPR013320; IPR000757; "Beta-1,3-glucan-binding protein (GBP)" Penaeus monodon (Giant tiger prawn) TR8472_c0_g1_i1 P28646 SSR1_RAT 3.00E-26 GO:0030217; GO:0071392; GO:0021549; GO:0005737; GO:0030900; GO:0007215; GO:0016021; GO:0005886; GO:0042594; GO:0004994; GO:0007283 T cell differentiation; cellular response to estradiol stimulus; cerebellum development; cytoplasm; forebrain development; glutamate receptor signaling pathway; integral to membrane; plasma membrane; response to starvation; somatostatin receptor activity; spermatogenesis IPR000276; IPR017452; IPR000586; IPR001116; Somatostatin receptor type 1 (SS-1-R) (SS1-R) (SS1R) (SRIF-2) Sstr1 Rattus norvegicus (Rat) TR8477_c0_g1_i1 Q08DY9 CASP3_BOVIN 1.00E-19 GO:0006915; GO:0004197; GO:0005737; GO:0006508 apoptotic process; cysteine-type endopeptidase activity; cytoplasm; proteolysis IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Bos taurus (Bovine) TR8484_c0_g1_i1 O96790 DPGN_DIPMA 4.00E-06 GO:0005576; GO:0050819; GO:0004867 extracellular region; negative regulation of coagulation; serine-type endopeptidase inhibitor activity IPR002350; Serine protease inhibitor dipetalogastin (Dipetalin) (Fragment) Dipetalogaster maximus (Blood-sucking bug) TR8499_c0_g1_i1 A6NGN9 IGLO5_HUMAN 7.00E-06 GO:0005576 extracellular region IPR007110; IPR013783; IPR003599; IPR003598; IPR013106; IgLON family member 5 IGLON5 Homo sapiens (Human) TR8499_c0_g2_i1 Q6X936 KIRR1_RAT 2.00E-08 GO:0031253; GO:0005911; GO:0016021; GO:0045121 cell projection membrane; cell-cell junction; integral to membrane; membrane raft IPR013162; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) Kirrel Kirrel1 Neph1 Rattus norvegicus (Rat) TR8520_c0_g1_i1 Q6IP73 NACA_XENLA 2.00E-68 GO:0015031 protein transport IPR016641; IPR002715; Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) naca Xenopus laevis (African clawed frog) TR8527_c0_g1_i1 C3YWU0 FUCO_BRAFL 4.00E-38 GO:0004560; GO:0005576; GO:0006004 alpha-L-fucosidase activity; extracellular region; fucose metabolic process IPR013780; IPR000933; IPR018526; IPR016286; IPR013781; IPR017853; Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) TR8531_c0_g1_i1 P05934 CALM_STRPU 1.00E-29 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) (Fragment) Strongylocentrotus purpuratus (Purple sea urchin) TR8531_c0_g1_i2 O97341 CALM_SUBDO 2.00E-53 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) Suberites domuncula (Sponge) TR8537_c1_g1_i1 Q25011 FANA_HELAS 1.00E-07 GO:0016021; GO:0005272; GO:0035725 integral to membrane; sodium channel activity; sodium ion transmembrane transport IPR001873; IPR020903; FMRFamide-activated amiloride-sensitive sodium channel (FANACH) Helix aspersa (Brown garden snail) (Cornu aspersum) TR8550_c0_g1_i1 Q54JL7 CNRN_DICDI 5.00E-12 GO:0031152; GO:0030835; GO:0030818; GO:0035335; GO:0016791; GO:0016314; GO:0004725; GO:0008138; GO:0014066 "aggregation involved in sorocarp development; negative regulation of actin filament depolymerization; negative regulation of cAMP biosynthetic process; peptidyl-tyrosine dephosphorylation; phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; regulation of phosphatidylinositol 3-kinase cascade" IPR000340; IPR014019; IPR014020; IPR016130; "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase cnrN (EC 3.1.3.67)" cnrN DDB_G0287969 Dictyostelium discoideum (Slime mold) TR8550_c1_g1_i1 Q4R6N0 TPTE2_MACFA 1.00E-41 GO:0005789; GO:0016021; GO:0005216; GO:0035335; GO:0016314; GO:0004725; GO:0008138 "endoplasmic reticulum membrane; integral to membrane; ion channel activity; peptidyl-tyrosine dephosphorylation; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity" IPR000008; IPR000340; IPR005821; IPR014019; IPR014020; IPR016130; "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67)" TPTE2 QtsA-17567 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR8555_c0_g1_i1 Q00593 ALKJ_PSEOL 1.00E-08 GO:0006066; GO:0008812; GO:0050660; GO:0005886 alcohol metabolic process; choline dehydrogenase activity; flavin adenine dinucleotide binding; plasma membrane IPR012132; IPR000172; IPR007867; Alcohol dehydrogenase [acceptor] (EC 1.1.99.-) alkJ alcO Pseudomonas oleovorans TR8574_c0_g1_i1 Q96RW7 HMCN1_HUMAN 3.00E-17 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR8577_c0_g1_i1 O08785 CLOCK_MOUSE 1.00E-36 GO:0000077; GO:0070888; GO:0000978; GO:0001077; GO:0001190; GO:0071479; GO:0005694; GO:0032922; GO:0005829; GO:0016573; GO:0004402; GO:0005654; GO:0004871; GO:0008134; GO:0005667 Q9WTL8; P97784; Q9JMK2; P67870; Q14995; O54943; P62136; P62140; P36873; P30154; Q14738; P20444; Q92753; P51449; Q923E4 DNA damage checkpoint; E-box binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; cellular response to ionizing radiation; chromosome; circadian regulation of gene expression; cytosol; histone acetylation; histone acetyltransferase activity; nucleoplasm; signal transducer activity; transcription factor binding; transcription factor complex IPR011598; IPR001067; IPR001610; IPR000014; IPR013767; Circadian locomoter output cycles protein kaput (mCLOCK) (EC 2.3.1.48) Clock Mus musculus (Mouse) TR8577_c0_g2_i1 Q8IV76 PASD1_HUMAN 4.00E-15 GO:0005634; GO:0004871 nucleus; signal transducer activity IPR000014; PAS domain-containing protein 1 (Cancer/testis antigen 63) (CT63) (OX-TES-1) PASD1 Homo sapiens (Human) TR8589_c0_g1_i1 P98165 VLDLR_CHICK 7.00E-09 GO:0005509; GO:0008203; GO:0005905; GO:0016021; GO:0006869; GO:0030228; GO:0021517; GO:0034361 calcium ion binding; cholesterol metabolic process; coated pit; integral to membrane; lipid transport; lipoprotein particle receptor activity; ventral spinal cord development; very-low-density lipoprotein particle IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR023415; IPR000033; IPR002172; Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) (Vitellogenin receptor) (VTG receptor) VLDLR VTGR Gallus gallus (Chicken) TR8623_c0_g1_i1 Q5UQ13 COLL2_MIMIV 7.00E-10 GO:0005581; GO:0019012 collagen; virion IPR008160; Collagen-like protein 2 MIMI_R196 Acanthamoeba polyphaga mimivirus (APMV) TR8627_c0_g1_i1 Q9Y2Q3 GSTK1_HUMAN 7.00E-33 GO:0006749; GO:0004602; GO:0004364; GO:0005743; GO:0005759; GO:0005777; GO:0015035 glutathione metabolic process; glutathione peroxidase activity; glutathione transferase activity; mitochondrial inner membrane; mitochondrial matrix; peroxisome; protein disulfide oxidoreductase activity IPR001853; IPR014440; IPR012336; Glutathione S-transferase kappa 1 (EC 2.5.1.18) (GST 13-13) (GST class-kappa) (GSTK1-1) (hGSTK1) (Glutathione S-transferase subunit 13) GSTK1 HDCMD47P Homo sapiens (Human) TR8640_c0_g1_i1 F1LZ52 KLHL3_RAT 4.00E-09 GO:0031463; GO:0005856; GO:0005829; GO:0072156; GO:0050801; GO:0070936; GO:0042787; GO:0070294 Cul3-RING ubiquitin ligase complex; cytoskeleton; cytosol; distal tubule morphogenesis; ion homeostasis; protein K48-linked ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; renal sodium ion absorption IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 3 Klhl3 Rattus norvegicus (Rat) TR8644_c1_g1_i1 Q6B4Z3 UTY_PANTR 4.00E-20 GO:0016568; GO:0051213; GO:0046872; GO:0005634 chromatin modification; dioxygenase activity; metal ion binding; nucleus IPR013026; IPR011990; IPR001440; IPR019734; Histone demethylase UTY (EC 1.14.11.-) (Ubiquitously transcribed TPR protein on the Y chromosome) (Ubiquitously transcribed Y chromosome tetratricopeptide repeat protein) UTY Pan troglodytes (Chimpanzee) TR8644_c1_g2_i1 Q96CB5 CH044_HUMAN 7.00E-15 Putative uncharacterized protein C8orf44 C8orf44 Homo sapiens (Human) TR8646_c0_g1_i1 Q55DY7 PSB2_DICDI 5.00E-22 GO:0005737; GO:0005634; GO:0005839; GO:0006508; GO:0051603; GO:0004298 cytoplasm; nucleus; proteasome core complex; proteolysis; proteolysis involved in cellular protein catabolic process; threonine-type endopeptidase activity IPR001353; IPR023333; Proteasome subunit beta type-2 (EC 3.4.25.1) psmB2 DDB_G0269472 Dictyostelium discoideum (Slime mold) TR8646_c0_g1_i2 P49721 PSB2_HUMAN 9.00E-30 GO:0006977; GO:0000082; GO:0031145; GO:0002479; GO:0006915; GO:0005829; GO:0010467; GO:0016071; GO:0019048; GO:0043066; GO:0051436; GO:0005654; GO:0051437; GO:0005839; GO:0000209; GO:0006521; GO:0014070; GO:0010243; GO:0044281; GO:0004298; GO:0016032 P49720 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G1/S transition of mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic process; cytosol; gene expression; mRNA metabolic process; modulation by virus of host morphology or physiology; negative regulation of apoptotic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; proteasome core complex; protein polyubiquitination; regulation of cellular amino acid metabolic process; response to organic cyclic compound; response to organonitrogen compound; small molecule metabolic process; threonine-type endopeptidase activity; viral process" IPR016050; IPR001353; IPR023333; Proteasome subunit beta type-2 (EC 3.4.25.1) (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I) (Proteasome component C7-I) PSMB2 Homo sapiens (Human) TR8650_c0_g1_i1 Q7RTY7 OVCH1_HUMAN 7.00E-22 GO:0005576; GO:0046872; GO:0006508; GO:0004252 extracellular region; metal ion binding; proteolysis; serine-type endopeptidase activity IPR000859; IPR001254; IPR018114; IPR001314; IPR009003; Ovochymase-1 (EC 3.4.21.-) OVCH1 Homo sapiens (Human) TR8653_c1_g1_i1 O54981 STIP1_CRIGR 2.00E-09 GO:0005737; GO:0005634 cytoplasm; nucleus IPR006636; IPR013026; IPR011990; IPR001440; IPR019734; Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) STIP1 HOP Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR8655_c0_g1_i1 O14638 ENPP3_HUMAN 6.00E-58 GO:0035529; GO:0005576; GO:0006955; GO:0005887; GO:0046872; GO:0003676; GO:0009143; GO:0047429; GO:0004551; GO:0048471; GO:0004528; GO:0030247; GO:0005044 NADH pyrophosphatase activity; extracellular region; immune response; integral to plasma membrane; metal ion binding; nucleic acid binding; nucleoside triphosphate catabolic process; nucleoside-triphosphate diphosphatase activity; nucleotide diphosphatase activity; perinuclear region of cytoplasm; phosphodiesterase I activity; polysaccharide binding; scavenger receptor activity IPR017849; IPR017850; IPR001604; IPR024873; IPR020821; IPR002591; IPR001212; Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (E-NPP 3) (Phosphodiesterase I beta) (PD-Ibeta) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (CD antigen CD203c) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9)] ENPP3 PDNP3 Homo sapiens (Human) TR8657_c1_g1_i1 P33450 FAT_DROME 5.00E-09 GO:0005509; GO:0016339; GO:0050839; GO:0030054; GO:0000904; GO:0008283; GO:0045317; GO:0048105; GO:0045198; GO:0001737; GO:0035329; GO:0007156; GO:0007446; GO:0005887; GO:0090176; GO:0030178; GO:0008285; GO:0045571; GO:0016318; GO:0018149; GO:0004872; GO:0035159 "calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; cell junction; cell morphogenesis involved in differentiation; cell proliferation; equator specification; establishment of body hair planar orientation; establishment of epithelial cell apical/basal polarity; establishment of imaginal disc-derived wing hair orientation; hippo signaling cascade; homophilic cell adhesion; imaginal disc growth; integral to plasma membrane; microtubule cytoskeleton organization involved in establishment of planar polarity; negative regulation of Wnt receptor signaling pathway; negative regulation of cell proliferation; negative regulation of imaginal disc growth; ommatidial rotation; peptide cross-linking; receptor activity; regulation of tube length, open tracheal system" IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR013032; IPR001791; Cadherin-related tumor suppressor (Protein fat) ft CG3352 Drosophila melanogaster (Fruit fly) TR8682_c1_g1_i1 P58308 OX2R_MOUSE 1.00E-27 GO:0022410; GO:0007631; GO:0016021; GO:0007218; GO:0016499; GO:0017046; GO:0007200; GO:0005886 circadian sleep/wake cycle process; feeding behavior; integral to membrane; neuropeptide signaling pathway; orexin receptor activity; peptide hormone binding; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane IPR000276; IPR017452; IPR000204; IPR004060; Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Mox2r Mus musculus (Mouse) TR8691_c1_g1_i1 B0DZL3 AMPP1_LACBS 1.00E-24 GO:0004177; GO:0009987; GO:0046872; GO:0008237; GO:0006508 aminopeptidase activity; cellular process; metal ion binding; metallopeptidase activity; proteolysis IPR000587; IPR000994; Probable Xaa-Pro aminopeptidase P (AMPP) (Aminopeptidase P) (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Prolidase) AMPP LACBIDRAFT_315028 Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor) TR8694_c1_g1_i1 Q3T0M7 RANG_BOVIN 3.00E-36 GO:0005096; GO:0046907; GO:0043547 GTPase activator activity; intracellular transport; positive regulation of GTPase activity IPR011993; IPR000156; Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) RANBP1 Bos taurus (Bovine) TR871_c0_g1_i1 Q7YRK2 COX6C_MACSL 3.00E-11 GO:0004129; GO:0016021; GO:0005743 cytochrome-c oxidase activity; integral to membrane; mitochondrial inner membrane IPR004204; Cytochrome c oxidase subunit 6C (Cytochrome c oxidase polypeptide VIc) COX6C Macaca silenus (Lion-tailed macaque) TR8721_c0_g2_i1 P07909 ROA1_DROME 1.00E-62 GO:0036099; GO:0048027; GO:0033119; GO:0000166; GO:0005634; GO:0048477; GO:0005703; GO:0045727; GO:0000381; GO:0030529; GO:0043565 "female germ-line stem cell maintenance; mRNA 5'-UTR binding; negative regulation of RNA splicing; nucleotide binding; nucleus; oogenesis; polytene chromosome puff; positive regulation of translation; regulation of alternative mRNA splicing, via spliceosome; ribonucleoprotein complex; sequence-specific DNA binding" IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (PEN repeat clone P9) (hnRNP core protein A1-A) Hrb98DE Pen9 CG9983 Drosophila melanogaster (Fruit fly) TR8731_c0_g1_i1 Q90404 AGRIN_DISOM 6.00E-14 GO:0030154; GO:0007275 cell differentiation; multicellular organismal development IPR008985; IPR013320; IPR000742; IPR013032; IPR000152; IPR002049; IPR003645; IPR002350; IPR001791; IPR000082; Agrin (Fragment) AGRN AGRIN Diplobatis ommata (Ocellated electric ray) (Discopyge ommata) TR8732_c0_g1_i1 P41351 TBA_TETTH 5.00E-65 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha chain (Alpha-tubulin) Tetrahymena thermophila TR8739_c0_g1_i1 Q494W8 CRFM7_HUMAN 1.00E-10 GO:0005230; GO:0016021 extracellular ligand-gated ion channel activity; integral to membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; CHRNA7-FAM7A fusion protein (CHRNA7-DR1) (D-10) CHRFAM7A Homo sapiens (Human) TR874_c0_g1_i1 Q9UKK3 PARP4_HUMAN 2.00E-22 GO:0003677; GO:0006281; GO:0003950; GO:0008219; GO:0005737; GO:0019899; GO:0006954; GO:0005634; GO:0006471; GO:0042493; GO:0030529; GO:0005876; GO:0006810 Q9Q2G4 DNA binding; DNA repair; NAD+ ADP-ribosyltransferase activity; cell death; cytoplasm; enzyme binding; inflammatory response; nucleus; protein ADP-ribosylation; response to drug; ribonucleoprotein complex; spindle microtubule; transport IPR001357; IPR012317; IPR004102; IPR013694; IPR002035; Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) TR8753_c0_g1_i1 Q5FWS6 KAZRN_RAT 1.00E-08 GO:0001533; GO:0005737; GO:0030057; GO:0031424; GO:0005634 cornified envelope; cytoplasm; desmosome; keratinization; nucleus IPR001660; IPR013761; IPR011510; IPR021129; Kazrin Kazn Kaz Rattus norvegicus (Rat) TR8761_c1_g1_i1 Q5XI81 FXR1_RAT 7.00E-11 GO:0003723; GO:0030154; GO:0005737; GO:0007517 RNA binding; cell differentiation; cytoplasm; muscle organ development IPR008395; IPR022034; IPR004087; IPR004088; Fragile X mental retardation syndrome-related protein 1 Fxr1 Fxr1h Rattus norvegicus (Rat) TR8763_c1_g1_i1 Q96RW7 HMCN1_HUMAN 6.00E-09 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR8766_c1_g1_i1 Q8NB78 KDM1B_HUMAN 5.00E-22 GO:0003677; GO:0043046; GO:0050660; GO:0034648; GO:0034649; GO:0007275; GO:0005634; GO:0016491; GO:0044030; GO:0006349; GO:0006355; GO:0006351; GO:0008270 "DNA binding; DNA methylation involved in gamete generation; flavin adenine dinucleotide binding; histone demethylase activity (H3-dimethyl-K4 specific); histone demethylase activity (H3-monomethyl-K4 specific); multicellular organismal development; nucleus; oxidoreductase activity; regulation of DNA methylation; regulation of gene expression by genetic imprinting; regulation of transcription, DNA-dependent; transcription, DNA-dependent; zinc ion binding" IPR002937; IPR009057; IPR007526; IPR011991; IPR011124; Lysine-specific histone demethylase 1B (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 2) KDM1B AOF1 C6orf193 LSD2 Homo sapiens (Human) TR879_c0_g1_i1 P59222 SREC2_MOUSE 6.00E-06 GO:0007157; GO:0016021; GO:0005044 heterophilic cell-cell adhesion; integral to membrane; scavenger receptor activity IPR000742; IPR013032; IPR009030; Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) TR8800_c0_g1_i1 Q7T0T9 PA24A_XENLA 1.00E-11 GO:0016023; GO:0004622; GO:0046872; GO:0004623; GO:0009395 cytoplasmic membrane-bounded vesicle; lysophospholipase activity; metal ion binding; phospholipase A2 activity; phospholipid catabolic process IPR016035; IPR000008; IPR002642; Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] pla2g4a cpla2 pla2g4 Xenopus laevis (African clawed frog) TR8802_c0_g1_i1 Q9UEW3 MARCO_HUMAN 4.00E-20 GO:0043277; GO:0007166; GO:0005581; GO:0030666; GO:0045087; GO:0005887; GO:0005044; GO:0008329; GO:0004888 apoptotic cell clearance; cell surface receptor signaling pathway; collagen; endocytic vesicle membrane; innate immune response; integral to plasma membrane; scavenger receptor activity; signaling pattern recognition receptor activity; transmembrane signaling receptor activity IPR008160; IPR001190; IPR017448; Macrophage receptor MARCO (Macrophage receptor with collagenous structure) (Scavenger receptor class A member 2) MARCO SCARA2 Homo sapiens (Human) TR8805_c0_g3_i1 Q21502 MEP1_CAEEL 5.00E-06 GO:0003723; GO:0008406; GO:0007506; GO:0040035; GO:0046872; GO:0005634; GO:0048599; GO:0010468; GO:0040025 Itself; P52012; G5EBZ4; P34498; G5EBT5; O45244; Q09530; Q94131 RNA binding; gonad development; gonadal mesoderm development; hermaphrodite genitalia development; metal ion binding; nucleus; oocyte development; regulation of gene expression; vulval development IPR007087; IPR015880; MOG interacting and ectopic P-granules protein 1 (Nuclear zinc finger protein) mep-1 M04B2.1 Caenorhabditis elegans TR8814_c0_g1_i1 Q9D967 MGDP1_MOUSE 3.00E-59 GO:0046872; GO:0035335; GO:0004725 metal ion binding; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity IPR023214; IPR010033; IPR024734; IPR010036; Magnesium-dependent phosphatase 1 (MDP-1) (EC 3.1.3.-) (EC 3.1.3.48) Mdp1 Mus musculus (Mouse) TR8825_c0_g1_i1 Q5BJJ7 BCCIP_DANRE 1.00E-17 GO:0006281; GO:0007049; GO:0005634 DNA repair; cell cycle; nucleus IPR025602; Protein BCCIP homolog bccip zgc:110272 Danio rerio (Zebrafish) (Brachydanio rerio) TR883_c0_g1_i1 Q19297 YZ73_CAEEL 3.00E-10 GO:0051537; GO:0045454; GO:0009055; GO:0046872; GO:0015035 "2 iron, 2 sulfur cluster binding; cell redox homeostasis; electron carrier activity; metal ion binding; protein disulfide oxidoreductase activity" IPR002109; IPR011899; IPR014025; IPR012336; Uncharacterized monothiol glutaredoxin F10D7.3 F10D7.3 Caenorhabditis elegans TR8830_c1_g1_i1 Q8N7X0 ADGB_HUMAN 1.00E-06 GO:0004198; GO:0020037; GO:0005622; GO:0005506; GO:0019825; GO:0015671; GO:0006508 calcium-dependent cysteine-type endopeptidase activity; heme binding; intracellular; iron ion binding; oxygen binding; oxygen transport; proteolysis IPR012292; IPR000048; IPR001300; Androglobin (Calpain-7-like protein) ADGB C6orf103 CAPN7L Homo sapiens (Human) TR8833_c1_g1_i1 Q53TQ3 IN80D_HUMAN 4.00E-26 GO:0006310; GO:0006281; GO:0005634; GO:0006355; GO:0006351 "DNA recombination; DNA repair; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR025927; INO80 complex subunit D INO80D Homo sapiens (Human) TR8845_c1_g1_i1 Q62645 NMDE4_RAT 2.00E-22 GO:0004972; GO:0017146; GO:0030054; GO:0005234; GO:0016595; GO:0042165; GO:0045211; GO:0035249; GO:0022843 Q63ZW7 "N-methyl-D-aspartate selective glutamate receptor activity; N-methyl-D-aspartate selective glutamate receptor complex; cell junction; extracellular-glutamate-gated ion channel activity; glutamate binding; neurotransmitter binding; postsynaptic membrane; synaptic transmission, glutamatergic; voltage-gated cation channel activity" IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; IPR001638; "Glutamate receptor ionotropic, NMDA 2D (GluN2D) (Glutamate [NMDA] receptor subunit epsilon-4) (N-methyl D-aspartate receptor subtype 2D) (NMDAR2D) (NR2D)" Grin2d GluN2D Rattus norvegicus (Rat) TR8862_c0_g1_i1 Q5VT06 CE350_HUMAN 1.00E-09 GO:0005813; GO:0005737; GO:0005634; GO:0005819 centrosome; cytoplasm; nucleus; spindle IPR000938; Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) CEP350 CAP350 KIAA0480 GM133 Homo sapiens (Human) TR8867_c0_g2_i1 Q55GE2 ODC_DICDI 1.00E-05 GO:0005310; GO:0016021; GO:0005743; GO:0006839 dicarboxylic acid transmembrane transporter activity; integral to membrane; mitochondrial inner membrane; mitochondrial transport IPR002067; IPR018108; IPR023395; Probable mitochondrial 2-oxodicarboxylate carrier (Solute carrier family 25 member 21) mcfT slc25a21 DDB_G0267704 Dictyostelium discoideum (Slime mold) TR8869_c0_g1_i1 Q9QXH4 ITAX_MOUSE 7.00E-24 GO:0007155; GO:0051607; GO:0009897; GO:0008305; GO:0007229; GO:0046872 cell adhesion; defense response to virus; external side of plasma membrane; integrin complex; integrin-mediated signaling pathway; metal ion binding IPR013517; IPR013519; IPR000413; IPR013649; IPR018184; IPR002035; "Integrin alpha-X (CD11 antigen-like family member C) (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (CD antigen CD11c)" Itgax Mus musculus (Mouse) TR8870_c0_g2_i1 Q5W7F2 AGD3_ARATH 3.00E-06 GO:0008060; GO:0005829; GO:0006897; GO:0009965; GO:0010087; GO:0035091; GO:0005886; GO:0032312; GO:0009733; GO:0030140; GO:0010051; GO:0008270 P42697 ARF GTPase activator activity; cytosol; endocytosis; leaf morphogenesis; phloem or xylem histogenesis; phosphatidylinositol binding; plasma membrane; regulation of ARF GTPase activity; response to auxin stimulus; trans-Golgi network transport vesicle; xylem and phloem pattern formation; zinc ion binding IPR027267; IPR002110; IPR020683; IPR001164; IPR004148; IPR011993; IPR001849; ADP-ribosylation factor GTPase-activating protein AGD3 (ARF GAP AGD3) (Protein ARF-GAP DOMAIN 3) (AtAGD3) (Protein SCARFACE) (Protein VASCULAR NETWORK 3) AGD3 SFC VAN3 At5g13300 T31B5.120 Arabidopsis thaliana (Mouse-ear cress) TR8870_c1_g1_i1 P16157 ANK1_HUMAN 8.00E-30 GO:0006888; GO:0031430; GO:0007411; GO:0016323; GO:0030863; GO:0008093; GO:0007010; GO:0005829; GO:0019899; GO:0048821; GO:0006887; GO:0045199; GO:0015672; GO:0006779; GO:0072661; GO:0016529; GO:0007165; GO:0030507; GO:0014731; GO:0005200 Q5VST9-3 ER to Golgi vesicle-mediated transport; M band; axon guidance; basolateral plasma membrane; cortical cytoskeleton; cytoskeletal adaptor activity; cytoskeleton organization; cytosol; enzyme binding; erythrocyte development; exocytosis; maintenance of epithelial cell apical/basal polarity; monovalent inorganic cation transport; porphyrin-containing compound biosynthetic process; protein targeting to plasma membrane; sarcoplasmic reticulum; signal transduction; spectrin binding; spectrin-associated cytoskeleton; structural constituent of cytoskeleton IPR002110; IPR020683; IPR011029; IPR000488; IPR000906; Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) TR8886_c1_g1_i1 O01479 TMOD_CAEEL 8.00E-16 GO:0051015; GO:0007015; GO:0051694; GO:0045214; GO:0005865 actin filament binding; actin filament organization; pointed-end actin filament capping; sarcomere organization; striated muscle thin filament IPR004934; Tropomodulin (Tmod-like protein) (cTmd1) (Uncoordinated protein 94) unc-94 tmd-1 C06A5.7 Caenorhabditis elegans TR8889_c0_g1_i1 Q95SX7 RTBS_DROME 1.00E-11 GO:0003723; GO:0006278; GO:0003964; GO:0006313 "RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; transposition, DNA-mediated" IPR005135; IPR000477; Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) TR89_c0_g1_i1 P24733 MYS_AEQIR 1.00E-38 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR015650; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, striated muscle" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR8905_c0_g1_i2 A8TX70 CO6A5_HUMAN 7.00E-07 GO:0007155; GO:0005581; GO:0030574; GO:0022617; GO:0005576 cell adhesion; collagen; collagen catabolic process; extracellular matrix disassembly; extracellular region IPR008160; IPR002035; Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) (von Willebrand factor A domain-containing protein 4) COL6A5 COL29A1 VWA4 Homo sapiens (Human) TR8920_c1_g1_i1 Q9BSU1 CP070_HUMAN 9.00E-23 P54252 IPR005373; UPF0183 protein C16orf70 C16orf70 C16orf6 Homo sapiens (Human) TR8925_c0_g1_i1 Q9Z0J0 NPC2_MOUSE 2.00E-10 GO:0015485; GO:0033344; GO:0042632; GO:0008203; GO:0005783; GO:0005576; GO:0032367; GO:0005764; GO:0009615 cholesterol binding; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; endoplasmic reticulum; extracellular region; intracellular cholesterol transport; lysosome; response to virus IPR014756; IPR003172; Epididymal secretory protein E1 (mE1) (Niemann Pick type C2 protein homolog) Npc2 Mus musculus (Mouse) TR8933_c0_g2_i1 Q91628 ORC2_XENLA 3.00E-07 GO:0006260; GO:0005634; GO:0000808 DNA replication; nucleus; origin recognition complex IPR007220; Origin recognition complex subunit 2 (xORC2) orc2 orc2l Xenopus laevis (African clawed frog) TR894_c0_g1_i1 Q5I2E5 FCN2_BOVIN 4.00E-07 GO:0005581; GO:0001867 "collagen; complement activation, lectin pathway" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) FCN2 Bos taurus (Bovine) TR8941_c1_g1_i1 Q27802 DYHC2_TRIGR 1.00E-34 GO:0005524; GO:0006200; GO:0016887; GO:0030031; GO:0001539; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018; GO:0007275; GO:0005886 ATP binding; ATP catabolic process; ATPase activity; cell projection assembly; ciliary or bacterial-type flagellar motility; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement; multicellular organismal development; plasma membrane IPR003593; IPR011704; IPR026983; IPR026815; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; Cytoplasmic dynein 2 heavy chain 1 (Dynein heavy chain isotype 1B) DYH1B Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla) TR8945_c1_g1_i1 P78363 ABCA4_HUMAN 2.00E-10 GO:0005524; GO:0042626; GO:0005887; GO:0006649; GO:0004012; GO:0045494; GO:0097381; GO:0007603; GO:0001523; GO:0007601 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; integral to plasma membrane; phospholipid transfer to membrane; phospholipid-translocating ATPase activity; photoreceptor cell maintenance; photoreceptor disc membrane; phototransduction, visible light; retinoid metabolic process; visual perception" IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; IPR005951; Retinal-specific ATP-binding cassette transporter (ATP-binding cassette sub-family A member 4) (RIM ABC transporter) (RIM protein) (RmP) (Stargardt disease protein) ABCA4 ABCR Homo sapiens (Human) TR8945_c2_g1_i1 O95477 ABCA1_HUMAN 3.00E-07 GO:0005524; GO:0006200; GO:0016887; GO:0007186; GO:0005794; GO:0008509; GO:0034188; GO:0044255; GO:0071222; GO:0071300; GO:0015485; GO:0033344; GO:0042632; GO:0008203; GO:0017127; GO:0016197; GO:0034380; GO:0005887; GO:0050702; GO:0032367; GO:0042157; GO:0007040; GO:0045121; GO:0010887; GO:0010745; GO:0002790; GO:0045335; GO:0006911; GO:0005543; GO:0033700; GO:0055091; GO:0045332; GO:0005548; GO:0060155; GO:0030819; GO:0010875; GO:0006497; GO:0032489; GO:0034616; GO:0055098; GO:0043691 Q13424; Q13884 "ATP binding; ATP catabolic process; ATPase activity; G-protein coupled receptor signaling pathway; Golgi apparatus; anion transmembrane transporter activity; apolipoprotein A-I receptor activity; cellular lipid metabolic process; cellular response to lipopolysaccharide; cellular response to retinoic acid; cholesterol binding; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transporter activity; endosomal transport; high-density lipoprotein particle assembly; integral to plasma membrane; interleukin-1 beta secretion; intracellular cholesterol transport; lipoprotein metabolic process; lysosome organization; membrane raft; negative regulation of cholesterol storage; negative regulation of macrophage derived foam cell differentiation; peptide secretion; phagocytic vesicle; phagocytosis, engulfment; phospholipid binding; phospholipid efflux; phospholipid homeostasis; phospholipid translocation; phospholipid transporter activity; platelet dense granule organization; positive regulation of cAMP biosynthetic process; positive regulation of cholesterol efflux; protein lipidation; regulation of Cdc42 protein signal transduction; response to laminar fluid shear stress; response to low-density lipoprotein particle stimulus; reverse cholesterol transport" IPR003593; IPR026082; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein) ABCA1 ABC1 CERP Homo sapiens (Human) TR8948_c0_g1_i1 Q6GLR7 CAPS1_XENLA 4.00E-17 GO:0030054; GO:0030659; GO:0006887; GO:0046872; GO:0005543; GO:0015031; GO:0045202 cell junction; cytoplasmic vesicle membrane; exocytosis; metal ion binding; phospholipid binding; protein transport; synapse IPR000008; IPR010439; IPR014770; IPR011993; IPR001849; Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1) cadps caps caps1 Xenopus laevis (African clawed frog) TR8958_c0_g1_i1 Q32LJ0 CCD23_BOVIN 4.00E-07 GO:0045177; GO:0010596; GO:0031397; GO:0009306 apical part of cell; negative regulation of endothelial cell migration; negative regulation of protein ubiquitination; protein secretion Coiled-coil domain-containing protein 23 CCDC23 Bos taurus (Bovine) TR8960_c0_g1_i1 Q9QYF3 MYO5A_RAT 9.00E-25 GO:0005524; GO:0042642; GO:0030424; GO:0032869; GO:0032593; GO:0000146; GO:0043025; GO:0043473; GO:0046982; GO:0072659; GO:0017157; GO:0032252; GO:0008021; GO:0030050; GO:0016192 "ATP binding; actomyosin, myosin complex part; axon; cellular response to insulin stimulus; insulin-responsive compartment; microfilament motor activity; neuronal cell body; pigmentation; protein heterodimerization activity; protein localization to plasma membrane; regulation of exocytosis; secretory granule localization; synaptic vesicle; vesicle transport along actin filament; vesicle-mediated transport" IPR018444; IPR002710; IPR000048; IPR001609; IPR027417; "Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle)" Myo5a Rattus norvegicus (Rat) TR8965_c0_g1_i1 Q8SRE2 H2B_ENCCU 3.00E-06 GO:0003677; GO:0000786; GO:0006334; GO:0005634 DNA binding; nucleosome; nucleosome assembly; nucleus IPR009072; IPR007125; IPR000558; Histone H2B HTB1 ECU08_0410 Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) TR8966_c1_g1_i1 Q99808 S29A1_HUMAN 3.00E-19 GO:0016324; GO:0016323; GO:0071333; GO:0071456; GO:0005887; GO:0007595; GO:0006139; GO:0005337; GO:0015858; GO:0060079; GO:0030431; GO:0015862 P49842 apical plasma membrane; basolateral plasma membrane; cellular response to glucose stimulus; cellular response to hypoxia; integral to plasma membrane; lactation; nucleobase-containing compound metabolic process; nucleoside transmembrane transporter activity; nucleoside transport; regulation of excitatory postsynaptic membrane potential; sleep; uridine transport IPR002259; IPR016196; "Equilibrative nucleoside transporter 1 (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1)" SLC29A1 ENT1 Homo sapiens (Human) TR897_c0_g1_i1 Q9VZZ4 PXDN_DROME 3.00E-08 GO:0030198; GO:0020037; GO:0042744; GO:0046872; GO:0004601; GO:0006909; GO:0005578 extracellular matrix organization; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity; phagocytosis; proteinaceous extracellular matrix IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR003591; IPR000372; IPR001007; Peroxidasin (EC 1.11.1.7) Pxn CG12002 Drosophila melanogaster (Fruit fly) TR8970_c0_g1_i1 Q9C0G6 DYH6_HUMAN 1.00E-23 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013602; IPR027417; "Dynein heavy chain 6, axonemal (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6)" DNAH6 DNAHC6 DNHL1 HL2 KIAA1697 Homo sapiens (Human) TR8973_c0_g1_i1 Q9MZD1 S17A5_SHEEP 3.00E-13 GO:0016021; GO:0005765; GO:0015293 integral to membrane; lysosomal membrane; symporter activity IPR011701; IPR020846; IPR016196; Sialin (Membrane glycoprotein SP55) (Sodium/sialic acid cotransporter) (Solute carrier family 17 member 5) SLC17A5 Ovis aries (Sheep) TR898_c0_g1_i1 O35598 ADA10_MOUSE 2.00E-06 GO:0005798; GO:0007220; GO:0007219; GO:0051088; GO:0042169; GO:0009986; GO:0051089; GO:0001701; GO:0016021; GO:0006509; GO:0004222; GO:0042117; GO:0007162; GO:0006913; GO:0005634; GO:0005886; GO:0010820; GO:0030307; GO:0008284; GO:0014069; GO:0019901; GO:0006468; GO:0034612; GO:0008270 Golgi-associated vesicle; Notch receptor processing; Notch signaling pathway; PMA-inducible membrane protein ectodomain proteolysis; SH2 domain binding; cell surface; constitutive protein ectodomain proteolysis; in utero embryonic development; integral to membrane; membrane protein ectodomain proteolysis; metalloendopeptidase activity; monocyte activation; negative regulation of cell adhesion; nucleocytoplasmic transport; nucleus; plasma membrane; positive regulation of T cell chemotaxis; positive regulation of cell growth; positive regulation of cell proliferation; postsynaptic density; protein kinase binding; protein phosphorylation; response to tumor necrosis factor; zinc ion binding IPR027053; IPR001762; IPR024079; IPR001590; IPR002870; Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c) Adam10 Kuz Madm Mus musculus (Mouse) TR8987_c0_g3_i1 Q9UDV7 ZN282_HUMAN 2.00E-07 GO:0003677; GO:0045892; GO:0005634; GO:0006351; GO:0008270 "DNA binding; negative regulation of transcription, DNA-dependent; nucleus; transcription, DNA-dependent; zinc ion binding" IPR022137; IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1) ZNF282 HUB1 Homo sapiens (Human) TR9001_c0_g1_i1 P21274 BMP2_MOUSE 3.00E-13 GO:0070700; GO:0003130; GO:0007219; GO:0060395; GO:0000187; GO:0003181; GO:0030282; GO:0035630; GO:0001658; GO:0060317; GO:0055007; GO:0055008; GO:0045165; GO:0009986; GO:0071773; GO:0071407; GO:0002062; GO:0060128; GO:0005125; GO:0035054; GO:0003203; GO:0001837; GO:0005615; GO:0040007; GO:0001701; GO:0006954; GO:0048839; GO:0072138; GO:0003308; GO:0032348; GO:0051042; GO:0090090; GO:2000726; GO:0045786; GO:0008285; GO:2000065; GO:0043569; GO:0000122; GO:0042475; GO:0001649; GO:0060389; GO:0060039; GO:0019211; GO:0070374; GO:0060804; GO:0043065; GO:0048711; GO:0030501; GO:0061036; GO:0030335; GO:0001938; GO:0010718; GO:0045600; GO:0045666; GO:0042482; GO:0045778; GO:0045669; GO:0033690; GO:1900745; GO:0010862; GO:0010922; GO:0045944; GO:1901522; GO:0031648; GO:0046982; GO:0006029; GO:0042487; GO:0001666; GO:0004745; GO:0021978; GO:0060129; GO:0007179 BMP receptor binding; BMP signaling pathway involved in heart induction; Notch signaling pathway; SMAD protein signal transduction; activation of MAPK activity; atrioventricular valve morphogenesis; bone mineralization; bone mineralization involved in bone maturation; branching involved in ureteric bud morphogenesis; cardiac epithelial to mesenchymal transition; cardiac muscle cell differentiation; cardiac muscle tissue morphogenesis; cell fate commitment; cell surface; cellular response to BMP stimulus; cellular response to organic cyclic compound; chondrocyte differentiation; corticotropin hormone secreting cell differentiation; cytokine activity; embryonic heart tube anterior/posterior pattern specification; endocardial cushion morphogenesis; epithelial to mesenchymal transition; extracellular space; growth; in utero embryonic development; inflammatory response; inner ear development; mesenchymal cell proliferation involved in ureteric bud development; negative regulation of Wnt receptor signaling pathway involved in heart development; negative regulation of aldosterone biosynthetic process; negative regulation of calcium-independent cell-cell adhesion; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of cardiac muscle cell differentiation; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of cortisol biosynthetic process; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; odontogenesis of dentin-containing tooth; osteoblast differentiation; pathway-restricted SMAD protein phosphorylation; pericardium development; phosphatase activator activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of Wnt receptor signaling pathway by BMP signaling pathway; positive regulation of apoptotic process; positive regulation of astrocyte differentiation; positive regulation of bone mineralization; positive regulation of cartilage development; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of fat cell differentiation; positive regulation of neuron differentiation; positive regulation of odontogenesis; positive regulation of ossification; positive regulation of osteoblast differentiation; positive regulation of osteoblast proliferation; positive regulation of p38MAPK cascade; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of phosphatase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; protein destabilization; protein heterodimerization activity; proteoglycan metabolic process; regulation of odontogenesis of dentin-containing tooth; response to hypoxia; retinol dehydrogenase activity; telencephalon regionalization; thyroid-stimulating hormone-secreting cell differentiation; transforming growth factor beta receptor signaling pathway IPR001839; IPR001111; IPR015615; IPR017948; Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A) Bmp2 Bmp-2 Mus musculus (Mouse) TR9007_c1_g1_i1 Q5U2S3 ZUFSP_RAT 8.00E-28 GO:0046872 metal ion binding IPR012462; IPR007087; IPR015880; Zinc finger with UFM1-specific peptidase domain protein Zufsp Rattus norvegicus (Rat) TR9018_c1_g1_i1 Q1RK13 Y220_RICBR 3.00E-14 IPR002110; IPR020683; Putative ankyrin repeat protein RBE_0220 RBE_0220 Rickettsia bellii (strain RML369-C) TR9026_c0_g1_i1 P82596 PLC_HALLA 2.00E-12 GO:0030246 carbohydrate binding IPR001304; IPR016186; IPR018378; IPR016187; Perlucin Haliotis laevigata (Abalone) TR9028_c1_g1_i1 Q7ZXS8 CALRL_XENLA 9.00E-16 GO:0004948; GO:0016021; GO:0005886 calcitonin receptor activity; integral to membrane; plasma membrane IPR003287; IPR017981; IPR003289; IPR001879; IPR000832; IPR017983; Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) calcrl Xenopus laevis (African clawed frog) TR9032_c0_g1_i1 Q3T102 EIF3E_BOVIN 1.00E-63 GO:0016605; GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0000184; GO:0006446; GO:0003743; GO:0006413 "PML body; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation preinitiation complex; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; regulation of translational initiation; translation initiation factor activity; translational initiation" IPR016650; IPR019010; IPR000717; IPR011991; Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (eIF-3 p48) EIF3E EIF3S6 INT6 Bos taurus (Bovine) TR9037_c0_g1_i1 P10272 POL_BAEVM 3.00E-07 GO:0015074; GO:0006310; GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0075713; GO:0090305; GO:0006508; GO:0004523; GO:0046718 DNA integration; DNA recombination; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; establishment of integrated proviral latency; nucleic acid phosphodiester bond hydrolysis; proteolysis; ribonuclease H activity; viral entry into host cell IPR001969; IPR001584; IPR018061; IPR001995; IPR021109; IPR012337; IPR002156; IPR000477; Pol polyprotein [Cleaved into: Protease (EC 3.4.23.-); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 3.1.26.4); Integrase (IN)] pol Baboon endogenous virus (strain M7) TR9045_c0_g1_i1 Q8I8U7 TRA1_DROME 7.00E-24 GO:0035267; GO:0000124; GO:0005737; GO:0016573; GO:0043486; GO:0005875; GO:0006909; GO:0016773; GO:0005703; GO:0045747; GO:0006355; GO:0006351; GO:0035222 "NuA4 histone acetyltransferase complex; SAGA complex; cytoplasm; histone acetylation; histone exchange; microtubule associated complex; phagocytosis; phosphotransferase activity, alcohol group as acceptor; polytene chromosome puff; positive regulation of Notch signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; wing disc pattern formation" IPR011989; IPR016024; IPR003152; IPR011009; IPR000403; IPR003151; IPR014009; Transcription-associated protein 1 (dTRA1) Nipped-A Tra1 CG2905 Drosophila melanogaster (Fruit fly) TR9047_c2_g1_i1 P20004 ACON_BOVIN 3.00E-47 GO:0051539; GO:0003994; GO:0006101; GO:0005506; GO:0005739; GO:0005634; GO:0006099 "4 iron, 4 sulfur cluster binding; aconitate hydratase activity; citrate metabolic process; iron ion binding; mitochondrion; nucleus; tricarboxylic acid cycle" IPR015931; IPR015937; IPR001030; IPR015928; IPR015932; IPR018136; IPR006248; IPR000573; Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. "Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)" ACO2 Bos taurus (Bovine) TR906_c0_g1_i1 Q12766 HMGX3_HUMAN 1.00E-11 GO:0003677; GO:0016301; GO:0005634 DNA binding; kinase activity; nucleus IPR009071; HMG domain-containing protein 3 (HMG box-containing protein 3) (Protein SMF) HMGXB3 KIAA0194 SMF Homo sapiens (Human) TR9075_c1_g1_i1 Q9P1Z9 CI174_HUMAN 4.00E-07 GO:0016021 integral to membrane IPR028089; IPR027914; IPR026701; Coiled-coil domain-containing protein 180 CCDC180 C9orf174 KIAA1529 Homo sapiens (Human) TR9078_c0_g1_i1 H2A0M7 PLSP_PINMG 2.00E-22 GO:0005576; GO:0020037; GO:0004601; GO:0006979 extracellular region; heme binding; peroxidase activity; response to oxidative stress IPR010255; IPR002007; IPR019791; Peroxidase-like protein Pinctada margaritifera (Black-lipped pearl oyster) TR9079_c1_g1_i1 Q63120 MRP2_RAT 8.00E-33 GO:0005524; GO:0006200; GO:0042626; GO:0016324; GO:0030644; GO:0006855; GO:0005887; GO:0046581; GO:0008514; GO:0015732; GO:0046685; GO:0043627; GO:0009408; GO:0031427; GO:0006979; GO:0070327 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; apical plasma membrane; cellular chloride ion homeostasis; drug transmembrane transport; integral to plasma membrane; intercellular canaliculus; organic anion transmembrane transporter activity; prostaglandin transport; response to arsenic-containing substance; response to estrogen stimulus; response to heat; response to methotrexate; response to oxidative stress; thyroid hormone transport" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Canalicular multispecific organic anion transporter 1 (ATP-binding cassette sub-family C member 2) (Canalicular multidrug resistance protein) (Multidrug resistance-associated protein 2) Abcc2 Cmoat Cmrp Mrp2 Rattus norvegicus (Rat) TR908_c0_g1_i1 Q39008 M3K1_ARATH 2.00E-08 GO:0005524; GO:0003677; GO:0004709; GO:0005634; GO:0046777; GO:1902065; GO:0009409; GO:0009651; GO:0009611; GO:0010449 Q94A06; Q9SUP6 ATP binding; DNA binding; MAP kinase kinase kinase activity; nucleus; protein autophosphorylation; response to L-glutamate; response to cold; response to salt stress; response to wounding; root meristem growth IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Mitogen-activated protein kinase kinase kinase 1 (ARAKIN) (AtMEKK1) (MAP kinase kinase kinase 1) (EC 2.7.11.25) MEKK1 At4g08500 T15F16.5 Arabidopsis thaliana (Mouse-ear cress) TR908_c1_g1_i1 Q0D598 WNK1_ORYSJ 2.00E-11 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR008271; Probable serine/threonine-protein kinase WNK1 (OsWNK1) (EC 2.7.11.1) (Mitogen-activated protein kinase kinase 1) (Protein kinase with no lysine 1) WNK1 MEK1 Os07g0572800 LOC_Os07g38530 OJ1121_A05.35-1 OJ1121_A05.35-2 OJ1699_E05.11-1 OJ1699_E05.11-2 OsJ_023858 Oryza sativa subsp. japonica (Rice) TR9086_c2_g1_i1 Q1L994 PPR37_DANRE 6.00E-43 GO:0010923; GO:0019902; GO:0004864 negative regulation of phosphatase activity; phosphatase binding; protein phosphatase inhibitor activity IPR001611; Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) ppp1r37 lrrc68 si:ch211-234g24.1 Danio rerio (Zebrafish) (Brachydanio rerio) TR9090_c0_g1_i1 P27075 RL44_CANTR 2.00E-45 GO:0046677; GO:0046898; GO:0005840; GO:0003735; GO:0006412 response to antibiotic; response to cycloheximide; ribosome; structural constituent of ribosome; translation IPR000552; IPR011332; 60S ribosomal protein L44 (60S ribosomal protein L41) RPL44 CTL41 RIM-C RPL41 Candida tropicalis (Yeast) TR9093_c0_g1_i1 Q8N0N3 BGBP_PENMO 3.00E-22 GO:0001872; GO:0005975; GO:0005576; GO:0004553; GO:0045087 "(1->3)-beta-D-glucan binding; carbohydrate metabolic process; extracellular region; hydrolase activity, hydrolyzing O-glycosyl compounds; innate immune response" IPR008985; IPR013320; IPR000757; "Beta-1,3-glucan-binding protein (GBP)" Penaeus monodon (Giant tiger prawn) TR910_c0_g1_i1 P28841 NEC2_RAT 4.00E-54 GO:0030425; GO:0009790; GO:0034230; GO:0005615; GO:0030070; GO:0034231; GO:0016020; GO:0007399; GO:0043204; GO:0016540; GO:0006508; GO:0004252; GO:0030133 P27682 dendrite; embryo development; enkephalin processing; extracellular space; insulin processing; islet amyloid polypeptide processing; membrane; nervous system development; perikaryon; protein autoprocessing; proteolysis; serine-type endopeptidase activity; transport vesicle IPR008979; IPR000209; IPR023827; IPR022398; IPR023828; IPR015500; IPR009020; IPR002884; Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2) Pcsk2 Nec-2 Nec2 Rpc2 Rattus norvegicus (Rat) TR9103_c1_g1_i1 Q9BXX0 EMIL2_HUMAN 3.00E-06 GO:0007155; GO:0005581; GO:0030023; GO:0005576 cell adhesion; collagen; extracellular matrix constituent conferring elasticity; extracellular region IPR001073; IPR011489; IPR008983; EMILIN-2 (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10) EMILIN2 Homo sapiens (Human) TR9105_c0_g1_i1 Q86XP1 DGKH_HUMAN 3.00E-99 GO:0005524; GO:0003951; GO:0004143; GO:0005768; GO:0035556; GO:0046872; GO:0031965; GO:0005543; GO:0005886; GO:0030168; GO:0007205; GO:0051259 ATP binding; NAD+ kinase activity; diacylglycerol kinase activity; endosome; intracellular signal transduction; metal ion binding; nuclear membrane; phospholipid binding; plasma membrane; platelet activation; protein kinase C-activating G-protein coupled receptor signaling pathway; protein oligomerization IPR016064; IPR000756; IPR001206; IPR011993; IPR001849; IPR002219; IPR001660; IPR013761; IPR011510; Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) DGKH Homo sapiens (Human) TR9105_c0_g2_i1 Q9Y6T7 DGKB_HUMAN 9.00E-12 GO:0005524; GO:0003951; GO:0005509; GO:0005737; GO:0004143; GO:0035556; GO:0005886; GO:0030168; GO:0007205 ATP binding; NAD+ kinase activity; calcium ion binding; cytoplasm; diacylglycerol kinase activity; intracellular signal transduction; plasma membrane; platelet activation; protein kinase C-activating G-protein coupled receptor signaling pathway IPR016064; IPR000756; IPR001206; IPR011992; IPR018247; IPR002048; IPR002219; Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta) DGKB DAGK2 KIAA0718 Homo sapiens (Human) TR9110_c0_g1_i1 A8WGF4 IF122_XENTR 0 GO:0005737; GO:0035721; GO:0030991; GO:0005932; GO:0007275; GO:0045879; GO:0072372 cytoplasm; intraflagellar retrograde transport; intraflagellar transport particle A; microtubule basal body; multicellular organismal development; negative regulation of smoothened signaling pathway; primary cilium IPR011990; IPR015943; IPR001680; IPR017986; Intraflagellar transport protein 122 homolog ift122 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR9110_c0_g1_i2 Q9JKU3 IF172_RAT 7.00E-06 GO:0005929; GO:0042384; GO:0007275; GO:0000122; GO:0005634; GO:0008134 cilium; cilium assembly; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription factor binding IPR011042; IPR016024; IPR015943; IPR001680; IPR017986; Intraflagellar transport protein 172 homolog (Selective LIM-binding factor) Ift172 Slb Rattus norvegicus (Rat) TR9110_c3_g1_i1 Q00808 HETE1_PODAS 3.00E-10 GO:0005525 GTP binding IPR020472; IPR010730; IPR007111; IPR027417; IPR015943; IPR001680; IPR019775; IPR017986; Vegetative incompatibility protein HET-E-1 HET-E1 Podospora anserina (Pleurage anserina) TR9112_c0_g1_i1 Q96PN6 ADCYA_HUMAN 7.00E-16 GO:0005524; GO:0004016; GO:0045177; GO:0030424; GO:0045178; GO:0005856; GO:0005829; GO:0030425; GO:0030426; GO:0035556; GO:0000287; GO:0030145; GO:0043025; GO:0048471; GO:0005886; GO:0043065; GO:0007283 ATP binding; adenylate cyclase activity; apical part of cell; axon; basal part of cell; cytoskeleton; cytosol; dendrite; growth cone; intracellular signal transduction; magnesium ion binding; manganese ion binding; neuronal cell body; perinuclear region of cytoplasm; plasma membrane; positive regulation of apoptotic process; spermatogenesis IPR001054; IPR016577; IPR027417; IPR011990; Adenylate cyclase type 10 (EC 4.6.1.1) (AH-related protein) (Adenylate cyclase homolog) (Germ cell soluble adenylyl cyclase) (hsAC) (sAC) (Testicular soluble adenylyl cyclase) ADCY10 SAC Homo sapiens (Human) TR9114_c0_g1_i1 Q6UXC1 AEGP_HUMAN 7.00E-15 GO:0016021; GO:0015031 integral to membrane; protein transport IPR008985; IPR023415; IPR002172; IPR000998; Apical endosomal glycoprotein (MAM domain-containing protein 4) MAMDC4 AEGP UNQ3001/PRO9742 Homo sapiens (Human) TR9114_c0_g1_i2 Q0WYX8 MDGA1_CHICK 3.00E-18 GO:0046658; GO:0001764 anchored to plasma membrane; neuron migration IPR008985; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000998; MAM domain-containing glycosylphosphatidylinositol anchor protein 1 MDGA1 Gallus gallus (Chicken) TR9124_c1_g1_i1 Q5JTD7 LRC73_HUMAN 6.00E-09 Leucine-rich repeat-containing protein 73 LRRC73 C6orf154 Homo sapiens (Human) TR9124_c1_g2_i1 Q9Y239 NOD1_HUMAN 4.00E-07 GO:0005524; GO:0050700; GO:0007254; GO:0002755; GO:0035666; GO:0000187; GO:0016324; GO:0016323; GO:0008656; GO:0005829; GO:0050830; GO:0042742; GO:0016045; GO:0042802; GO:0006954; GO:0045087; GO:0042228; GO:0070423; GO:0042834; GO:0070374; GO:0043123; GO:0046330; GO:0051092; GO:0002606; GO:0032755; GO:0032760; GO:0051259; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124 Itself ATP binding; CARD domain binding; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; activation of MAPK activity; apical plasma membrane; basolateral plasma membrane; cysteine-type endopeptidase activator activity involved in apoptotic process; cytosol; defense response to Gram-positive bacterium; defense response to bacterium; detection of bacterium; identical protein binding; inflammatory response; innate immune response; interleukin-8 biosynthetic process; nucleotide-binding oligomerization domain containing signaling pathway; peptidoglycan binding; positive regulation of ERK1 and ERK2 cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of dendritic cell antigen processing and presentation; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; protein oligomerization; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor TLR1:TLR2 signaling pathway; toll-like receptor TLR6:TLR2 signaling pathway IPR001315; IPR011029; IPR007111; Nucleotide-binding oligomerization domain-containing protein 1 (Caspase recruitment domain-containing protein 4) NOD1 CARD4 Homo sapiens (Human) TR9126_c0_g1_i1 Q6TFL3 CC171_HUMAN 3.00E-12 Coiled-coil domain-containing protein 171 CCDC171 C9orf93 Homo sapiens (Human) TR9133_c1_g1_i1 Q2VL56 PAX9_SAGOE 5.00E-52 GO:0003677; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009057; IPR001523; IPR011991; Paired box protein Pax-9 PAX9 Saguinus oedipus (Cotton-top tamarin) TR9134_c0_g2_i1 Q8CDN9 LRRC9_MOUSE 4.00E-20 IPR001611; IPR025875; IPR003603; Leucine-rich repeat-containing protein 9 Lrrc9 Mus musculus (Mouse) TR9135_c0_g2_i1 Q8NEV4 MYO3A_HUMAN 4.00E-30 GO:0043531; GO:0005524; GO:0030898; GO:0005516; GO:0005737; GO:0031941; GO:0030175; GO:0032433; GO:0048839; GO:0016459; GO:0018105; GO:0018107; GO:0001917; GO:0060002; GO:0051491; GO:0046777; GO:0004672; GO:0004674; GO:0050896; GO:0007605; GO:0032426; GO:0007601 ADP binding; ATP binding; actin-dependent ATPase activity; calmodulin binding; cytoplasm; filamentous actin; filopodium; filopodium tip; inner ear development; myosin complex; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; photoreceptor inner segment; plus-end directed microfilament motor activity; positive regulation of filopodium assembly; protein autophosphorylation; protein kinase activity; protein serine/threonine kinase activity; response to stimulus; sensory perception of sound; stereocilium bundle tip; visual perception IPR000048; IPR011009; IPR001609; IPR027417; IPR000719; IPR017441; IPR002290; Myosin-IIIa (EC 2.7.11.1) MYO3A Homo sapiens (Human) TR9140_c0_g1_i1 P28073 PSB6_RAT 1.00E-56 GO:0005737; GO:0005634; GO:0005839; GO:0051603; GO:0004298 cytoplasm; nucleus; proteasome core complex; proteolysis involved in cellular protein catabolic process; threonine-type endopeptidase activity IPR000243; IPR016050; IPR001353; IPR023333; Proteasome subunit beta type-6 (EC 3.4.25.1) (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome chain 5) (Proteasome delta chain) (Proteasome subunit Y) Psmb6 Psmb6l Rattus norvegicus (Rat) TR9155_c0_g1_i1 Q6GNT2 CL049_XENLA 2.00E-16 GO:0005576 extracellular region IPR019352; UPF0454 protein C12orf49 homolog Xenopus laevis (African clawed frog) TR9155_c2_g1_i1 Q503V3 CL049_DANRE 2.00E-15 GO:0005576 extracellular region IPR019352; UPF0454 protein C12orf49 homolog zgc:110063 Danio rerio (Zebrafish) (Brachydanio rerio) TR9159_c0_g1_i1 O73792 TIE1_DANRE 1.00E-31 GO:0005524; GO:0001525; GO:0016021; GO:0018108; GO:0005886; GO:0004714 ATP binding; angiogenesis; integral to membrane; peptidyl-tyrosine phosphorylation; plasma membrane; transmembrane receptor protein tyrosine kinase activity IPR011009; IPR000719; IPR001245; IPR008266; Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) (Fragment) tie1 tie-1 Danio rerio (Zebrafish) (Brachydanio rerio) TR9159_c0_g2_i1 P00540 MOS_HUMAN 5.00E-08 GO:0005524; GO:0004674; GO:0040020 ATP binding; protein serine/threonine kinase activity; regulation of meiosis IPR011009; IPR000719; IPR017441; IPR008271; Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte maturation factor mos) (Proto-oncogene c-Mos) MOS Homo sapiens (Human) TR9159_c0_g3_i1 Q8BKG3 PTK7_MOUSE 7.00E-34 GO:0003401; GO:0007155; GO:0030054; GO:0090103; GO:0060026; GO:0045198; GO:0001736; GO:0016021; GO:0060484; GO:0016020; GO:0001843; GO:0090179; GO:0016772; GO:0042060 "axis elongation; cell adhesion; cell junction; cochlea morphogenesis; convergent extension; establishment of epithelial cell apical/basal polarity; establishment of planar polarity; integral to membrane; lung-associated mesenchyme development; membrane; neural tube closure; planar cell polarity pathway involved in neural tube closure; transferase activity, transferring phosphorus-containing groups; wound healing" IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR001245; IPR008266; IPR020635; Inactive tyrosine-protein kinase 7 (Protein chuzhoi) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7) Ptk7 Mus musculus (Mouse) TR9162_c0_g1_i1 P21837 CRYS_DICDI 9.00E-24 GO:0004091; GO:0033118 carboxylesterase activity; esterosome membrane IPR002018; IPR019826; IPR019819; Crystal protein cryS DDB_G0285419 Dictyostelium discoideum (Slime mold) TR9163_c0_g1_i1 Q5UPF8 YL088_MIMIV 3.00E-07 IPR002110; IPR020683; Putative ankyrin repeat protein L88 MIMI_L88 Acanthamoeba polyphaga mimivirus (APMV) TR9163_c0_g2_i1 Q5UPG5 YL093_MIMIV 1.00E-10 IPR002110; IPR020683; Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) TR9164_c0_g1_i1 P16924 P4HA1_CHICK 9.00E-21 GO:0031418; GO:0005788; GO:0005506; GO:0016702; GO:0004656 "L-ascorbic acid binding; endoplasmic reticulum lumen; iron ion binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; procollagen-proline 4-dioxygenase activity" IPR005123; IPR006620; IPR013547; IPR013026; IPR011990; IPR019734; "Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)" P4HA1 P4HA Gallus gallus (Chicken) TR9168_c1_g1_i1 B0JZG0 S23A2_XENTR 7.00E-22 GO:0016021; GO:0006814; GO:0015293 integral to membrane; sodium ion transport; symporter activity IPR006042; IPR006043; Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR9173_c0_g1_i1 Q7ZT11 ANKR1_CHICK 9.00E-15 GO:0005634 nucleus IPR002110; IPR020683; Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) ANKRD1 CARP Gallus gallus (Chicken) TR9174_c0_g1_i1 Q13360 ZN177_HUMAN 5.00E-34 GO:0003677; GO:0046872; GO:0000122; GO:0005634; GO:0006351 "DNA binding; metal ion binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 177 ZNF177 Homo sapiens (Human) TR9174_c0_g1_i2 A6QQW0 ZN143_BOVIN 6.00E-20 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 143 (Selenocysteine tRNA gene transcription-activating factor) ZNF143 STAF Bos taurus (Bovine) TR9176_c0_g1_i1 O94760 DDAH1_HUMAN 9.00E-10 GO:0016597; GO:0006527; GO:0000052; GO:0016403; GO:0046872; GO:0005739; GO:0007263; GO:0045766; GO:0045429; GO:0003073 amino acid binding; arginine catabolic process; citrulline metabolic process; dimethylargininase activity; metal ion binding; mitochondrion; nitric oxide mediated signal transduction; positive regulation of angiogenesis; positive regulation of nitric oxide biosynthetic process; regulation of systemic arterial blood pressure IPR003198; "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) (Dimethylargininase-1)" DDAH1 DDAH Homo sapiens (Human) TR9184_c0_g1_i1 Q3B8D5 KATL2_XENLA 4.00E-34 GO:0005524; GO:0005737; GO:0005874; GO:0051013; GO:0008568 ATP binding; cytoplasm; microtubule; microtubule severing; microtubule-severing ATPase activity IPR003593; IPR003959; IPR027497; IPR006594; IPR013720; IPR027417; Katanin p60 ATPase-containing subunit A-like 2 (Katanin p60 subunit A-like 2) (EC 3.6.4.3) (p60 katanin-like 2) katnal2 Xenopus laevis (African clawed frog) TR9193_c0_g1_i1 A6QQU6 TM144_BOVIN 7.00E-33 GO:0016021 integral to membrane IPR012435; Transmembrane protein 144 TMEM144 Bos taurus (Bovine) TR9204_c1_g1_i1 P50747 BPL1_HUMAN 5.00E-30 GO:0005524; GO:0009374; GO:0006768; GO:0004077; GO:0004078; GO:0004079; GO:0004080; GO:0008283; GO:0000785; GO:0005829; GO:0071110; GO:0005739; GO:0005652; GO:0016363; GO:0070781 O00763 ATP binding; biotin binding; biotin metabolic process; biotin-[acetyl-CoA-carboxylase] ligase activity; biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity; biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity; biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity; cell proliferation; chromatin; cytosol; histone biotinylation; mitochondrion; nuclear lamina; nuclear matrix; response to biotin IPR004408; IPR003142; IPR004143; Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] HLCS Homo sapiens (Human) TR9204_c2_g1_i1 P48445 BPL1_YEAST 3.00E-07 GO:0005524; GO:0004077; GO:0004078; GO:0004079; GO:0004080; GO:0071734; GO:0005737; GO:0009305 ATP binding; biotin-[acetyl-CoA-carboxylase] ligase activity; biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity; biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity; biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity; biotin-[pyruvate-carboxylase] ligase activity; cytoplasm; protein biotinylation IPR019197; IPR004408; IPR003142; IPR004143; Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] BPL1 ACC2 YDL141W D2140 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR9209_c0_g1_i1 P46023 GR101_LYMST 4.00E-16 GO:0016021; GO:0005886; GO:0016500 integral to membrane; plasma membrane; protein-hormone receptor activity IPR000276; IPR017452; IPR002131; IPR023415; IPR002172; IPR001611; IPR003591; IPR000372; G-protein coupled receptor GRL101 Lymnaea stagnalis (Great pond snail) TR9225_c1_g1_i1 Q66HD8 F221B_RAT 4.00E-26 IPR026755; Protein FAM221B Fam221b Rattus norvegicus (Rat) TR9228_c0_g1_i1 Q58EX7 PKHG4_HUMAN 5.00E-21 GO:0005089; GO:0005543; GO:0035023 Rho guanyl-nucleotide exchange factor activity; phospholipid binding; regulation of Rho protein signal transduction IPR001251; IPR000219; IPR011993; IPR001849; Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1) PLEKHG4 PRTPHN1 Homo sapiens (Human) TR9229_c0_g1_i1 Q64419 EST1_MESAU 9.00E-06 GO:0004091; GO:0005788 carboxylesterase activity; endoplasmic reticulum lumen IPR002018; IPR019826; IPR019819; Liver carboxylesterase (EC 3.1.1.1) Mesocricetus auratus (Golden hamster) TR9232_c0_g1_i1 Q6JEL3 KLH10_RAT 0 GO:0000902; GO:0005737; GO:0009566; GO:0048873; GO:0048808; GO:0008584; GO:0016567; GO:0007286 cell morphogenesis; cytoplasm; fertilization; homeostasis of number of cells within a tissue; male genitalia morphogenesis; male gonad development; protein ubiquitination; spermatid development IPR011705; IPR000210; IPR011333; IPR013069; IPR015916; IPR017096; IPR006652; Protein modification; protein ubiquitination. Kelch-like protein 10 Klhl10 Rattus norvegicus (Rat) TR9234_c0_g1_i1 P46023 GR101_LYMST 3.00E-39 GO:0016021; GO:0005886; GO:0016500 integral to membrane; plasma membrane; protein-hormone receptor activity IPR000276; IPR017452; IPR002131; IPR023415; IPR002172; IPR001611; IPR003591; IPR000372; G-protein coupled receptor GRL101 Lymnaea stagnalis (Great pond snail) TR9244_c0_g1_i1 Q07954 LRP1_HUMAN 3.00E-09 GO:0035909; GO:0034185; GO:0043277; GO:0097242; GO:0005509; GO:0008203; GO:0005905; GO:0030666; GO:0005887; GO:0070325; GO:0042954; GO:0005765; GO:0030178; GO:2000587; GO:0014912; GO:0005634; GO:0007603; GO:0010875; GO:0032403; GO:0004872; GO:0006898; GO:0032956; GO:0032429; GO:0001523 O00213; Q15485; Q63722; P11226; Q03350 "aorta morphogenesis; apolipoprotein binding; apoptotic cell clearance; beta-amyloid clearance; calcium ion binding; cholesterol metabolic process; coated pit; endocytic vesicle membrane; integral to plasma membrane; lipoprotein particle receptor binding; lipoprotein transporter activity; lysosomal membrane; negative regulation of Wnt receptor signaling pathway; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; negative regulation of smooth muscle cell migration; nucleus; phototransduction, visible light; positive regulation of cholesterol efflux; protein complex binding; receptor activity; receptor-mediated endocytosis; regulation of actin cytoskeleton organization; regulation of phospholipase A2 activity; retinoid metabolic process" IPR011042; IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR023415; IPR000033; IPR002172; Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)] LRP1 A2MR APR Homo sapiens (Human) TR9250_c0_g1_i1 Q9U6A0 NCKX_DROME 2.00E-06 GO:0008273; GO:0048749; GO:0016021; GO:0048812; GO:0015293 "calcium, potassium:sodium antiporter activity; compound eye development; integral to membrane; neuron projection morphogenesis; symporter activity" IPR004481; IPR004837; Sodium/potassium/calcium exchanger Nckx30C (Na(+)/K(+)/Ca(2+)-exchange protein Nckx30C) Nckx30C CG18660 Drosophila melanogaster (Fruit fly) TR9256_c0_g1_i1 Q05187 TGMH_TACTR 7.00E-10 GO:0016020; GO:0046872; GO:0018149; GO:0003810 membrane; metal ion binding; peptide cross-linking; protein-glutamine gamma-glutamyltransferase activity IPR023608; IPR013783; IPR014756; IPR002931; IPR008958; IPR013808; IPR001102; Hemocyte protein-glutamine gamma-glutamyltransferase (EC 2.3.2.13) (Hemocyte transglutaminase) (TGase) Tachypleus tridentatus (Japanese horseshoe crab) TR9258_c0_g1_i1 Q8IZU2 WDR17_HUMAN 8.00E-51 IPR020472; IPR011047; IPR015943; IPR001680; IPR019775; IPR017986; WD repeat-containing protein 17 WDR17 Homo sapiens (Human) TR9264_c0_g1_i2 Q5QGZ9 CL12A_HUMAN 6.00E-06 GO:0030246; GO:0016021; GO:0005886 carbohydrate binding; integral to membrane; plasma membrane IPR001304; IPR016186; IPR016187; C-type lectin domain family 12 member A (C-type lectin-like molecule 1) (CLL-1) (Dendritic cell-associated lectin 2) (DCAL-2) (Myeloid inhibitory C-type lectin-like receptor) (MICL) CLEC12A CLL1 DCAL2 MICL Homo sapiens (Human) TR9266_c0_g1_i1 O60237 MYPT2_HUMAN 2.00E-16 GO:0000086; GO:0015629; GO:0005737; GO:0008047; GO:0005654; GO:0005886; GO:0006937; GO:0007165 G2/M transition of mitotic cell cycle; actin cytoskeleton; cytoplasm; enzyme activator activity; nucleoplasm; plasma membrane; regulation of muscle contraction; signal transduction IPR002110; IPR020683; IPR017401; Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) PPP1R12B MYPT2 Homo sapiens (Human) TR9266_c1_g1_i1 Q5U2S6 ASB2_RAT 2.00E-21 GO:0031466; GO:0035556; GO:0045445; GO:0000209; GO:0042787; GO:0035914; GO:0004842 Cul5-RING ubiquitin ligase complex; intracellular signal transduction; myoblast differentiation; protein polyubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; skeletal muscle cell differentiation; ubiquitin-protein ligase activity IPR002110; IPR020683; IPR001496; Protein modification; protein ubiquitination. Ankyrin repeat and SOCS box protein 2 (ASB-2) Asb2 Rattus norvegicus (Rat) TR9274_c0_g1_i1 P86854 PLCL_MYTGA 2.00E-11 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR9277_c1_g1_i1 Q9QWH1 PHC2_MOUSE 4.00E-08 GO:0003677; GO:0035102; GO:0031519; GO:0007275; GO:0007283; GO:0008270 P25916; P49137; P49138; P23798; Q64028; O35730; Q9CQJ4 DNA binding; PRC1 complex; PcG protein complex; multicellular organismal development; spermatogenesis; zinc ion binding IPR001660; IPR013761; IPR021129; IPR012313; Polyhomeotic-like protein 2 (mPH2) (Early development regulatory protein 2) (p36) Phc2 Edr2 Ph2 Mus musculus (Mouse) TR9277_c2_g1_i1 A1L0Y2 NEUL4_XENTR 2.00E-36 GO:0005814 centriole IPR008985; IPR006573; Neuralized-like protein 4 neurl4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR9288_c1_g1_i1 P05031 DDC_DROME 3.00E-08 GO:0048085; GO:0007615; GO:0004058; GO:0007619; GO:0006585; GO:0008062; GO:0040007; GO:0007616; GO:0030170; GO:0048082; GO:0009611; GO:0006587; GO:0040040; GO:0043052; GO:0035220 adult chitin-containing cuticle pigmentation; anesthesia-resistant memory; aromatic-L-amino-acid decarboxylase activity; courtship behavior; dopamine biosynthetic process from tyrosine; eclosion rhythm; growth; long-term memory; pyridoxal phosphate binding; regulation of adult chitin-containing cuticle pigmentation; response to wounding; serotonin biosynthetic process from tryptophan; thermosensory behavior; thermotaxis; wing disc development IPR010977; IPR002129; IPR015424; IPR015421; IPR015422; IPR021115; Aromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC) Ddc CG10697 Drosophila melanogaster (Fruit fly) TR9291_c0_g1_i1 Q5XK67 RPAC2_XENLA 2.00E-24 GO:0003677; GO:0003899; GO:0005634; GO:0006351 "DNA binding; DNA-directed RNA polymerase activity; nucleus; transcription, DNA-dependent" IPR009025; IPR008193; DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerase I subunit D) polr1d Xenopus laevis (African clawed frog) TR9295_c0_g1_i1 Q9DGD1 MGT4C_CHICK 5.00E-21 GO:0000139; GO:0008454; GO:0016021; GO:0046872; GO:0006486 "Golgi membrane; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; integral to membrane; metal ion binding; protein glycosylation" IPR006759; Protein modification; protein glycosylation. "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.-) (EC 2.4.1.145) (N-acetylglucosaminyltransferase VI) (GnT-VI) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)" MGAT4C Gallus gallus (Chicken) TR930_c0_g1_i1 Q1HR24 RS14_AEDAE 5.00E-88 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR001971; IPR018102; 40S ribosomal protein S14 RpS14 AAEL005266 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) TR9300_c0_g1_i1 Q95003 GPX3_CAEEL 3.00E-38 GO:0005615; GO:0004602; GO:0006979 extracellular space; glutathione peroxidase activity; response to oxidative stress IPR000889; IPR012336; Glutathione peroxidase 3 (EC 1.11.1.9) gpx-3 C11E4.2 Caenorhabditis elegans TR9302_c0_g1_i1 P70298 CUX2_MOUSE 5.00E-07 GO:0003677; GO:0071310; GO:0045892; GO:0005634; GO:0043565; GO:0003700; GO:0006351 "DNA binding; cellular response to organic substance; negative regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR003350; IPR017970; IPR001356; IPR009057; IPR010982; Homeobox protein cut-like 2 (Homeobox protein Cux-2) Cux2 Cutl2 Mus musculus (Mouse) TR9303_c0_g2_i1 Q7Z7M0 MEGF8_HUMAN 1.00E-23 GO:0005509; GO:0071907; GO:0061371; GO:0016021; GO:0005634; GO:0004872; GO:0005198 O15265; O00555 calcium ion binding; determination of digestive tract left/right asymmetry; determination of heart left/right asymmetry; integral to membrane; nucleus; receptor activity; structural molecule activity IPR000859; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR002049; IPR015915; IPR016201; IPR002165; Multiple epidermal growth factor-like domains protein 8 (Multiple EGF-like domains protein 8) (Epidermal growth factor-like protein 4) (EGF-like protein 4) MEGF8 C19orf49 EGFL4 KIAA0817 Homo sapiens (Human) TR9306_c0_g1_i1 Q5RDF5 JAZF1_PONAB 2.00E-14 GO:0046872; GO:0003676; GO:0005634; GO:0006355; GO:0006351 "metal ion binding; nucleic acid binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Juxtaposed with another zinc finger protein 1 JAZF1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR9307_c0_g1_i1 Q2KJI2 STT3A_BOVIN 2.00E-32 GO:0043686; GO:0004579; GO:0016021; GO:0008250; GO:0018279 co-translational protein modification; dolichyl-diphosphooligosaccharide-protein glycotransferase activity; integral to membrane; oligosaccharyltransferase complex; protein N-linked glycosylation via asparagine IPR003674; Protein modification; protein glycosylation. Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (Oligosaccharyl transferase subunit STT3A) (STT3-A) (EC 2.4.99.18) STT3A Bos taurus (Bovine) TR931_c1_g1_i1 Q6PCN7 HLTF_MOUSE 2.00E-22 GO:0005524; GO:0016887; GO:0003677; GO:0016568; GO:0005737; GO:0004386; GO:0016874; GO:0005730; GO:0005654; GO:0016567; GO:0006357; GO:0006351; GO:0008270 "ATP binding; ATPase activity; DNA binding; chromatin modification; cytoplasm; helicase activity; ligase activity; nucleolus; nucleoplasm; protein ubiquitination; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; zinc ion binding" IPR014001; IPR001650; IPR014905; IPR027417; IPR000330; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. Helicase-like transcription factor (EC 3.6.4.-) (EC 6.3.2.-) (P113) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) (TNF-response element-binding protein) Hltf Smarca3 Snf2l3 Zbu1 Mus musculus (Mouse) TR9311_c0_g1_i1 Q641Y2 NDUS2_RAT 6.00E-58 GO:0051539; GO:0051287; GO:0008137; GO:0046872; GO:0005747; GO:0048038; GO:0006979 "4 iron, 4 sulfur cluster binding; NAD binding; NADH dehydrogenase (ubiquinone) activity; metal ion binding; mitochondrial respiratory chain complex I; quinone binding; response to oxidative stress" IPR001135; IPR014029; IPR022885; "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-49kD) (CI-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit)" Ndufs2 Rattus norvegicus (Rat) TR9318_c0_g2_i1 P08472 M130_STRPU 3.00E-24 GO:0031225; GO:0016787; GO:0009166; GO:0005886 anchored to membrane; hydrolase activity; nucleotide catabolic process; plasma membrane IPR006179; IPR015943; Mesenchyme-specific cell surface glycoprotein (MSP130) Strongylocentrotus purpuratus (Purple sea urchin) TR9322_c0_g1_i1 P81926 SODC_HALRO 3.00E-39 GO:0005737; GO:0046872; GO:0004784; GO:0006801 cytoplasm; metal ion binding; superoxide dismutase activity; superoxide metabolic process IPR024134; IPR018152; IPR001424; Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) Halocynthia roretzi (Sea squirt) TR9331_c1_g1_i1 O01404 PHM_DROME 6.00E-12 GO:0005507; GO:0005615; GO:0016020; GO:0007613; GO:0032504; GO:0006518; GO:0004504 copper ion binding; extracellular space; membrane; memory; multicellular organism reproduction; peptide metabolic process; peptidylglycine monooxygenase activity IPR014784; IPR014783; IPR000323; IPR000720; IPR008977; Peptidylglycine alpha-hydroxylating monooxygenase (dPHM) (EC 1.14.17.3) Phm CG3832 Drosophila melanogaster (Fruit fly) TR9335_c0_g1_i1 Q8TEM1 PO210_HUMAN 4.00E-22 GO:0005975; GO:0019221; GO:0005789; GO:0015758; GO:0051028; GO:0007077; GO:0005635; GO:0031965; GO:0005643; GO:0015031; GO:0010827; GO:0044281; GO:0055085; GO:0016032 carbohydrate metabolic process; cytokine-mediated signaling pathway; endoplasmic reticulum membrane; glucose transport; mRNA transport; mitotic nuclear envelope disassembly; nuclear envelope; nuclear membrane; nuclear pore; protein transport; regulation of glucose transport; small molecule metabolic process; transmembrane transport; viral process IPR003343; IPR008964; Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) NUP210 KIAA0906 PSEC0245 Homo sapiens (Human) TR934_c0_g1_i1 P91645 CAC1A_DROME 2.00E-39 GO:0008344; GO:0016324; GO:0016323; GO:0005509; GO:0050908; GO:0042045; GO:0006887; GO:0008331; GO:0008332; GO:0045433; GO:0007275; GO:0007269; GO:0007602; GO:0045887; GO:0048786; GO:0002027; GO:0046928; GO:0007632; GO:0005891 "adult locomotory behavior; apical plasma membrane; basolateral plasma membrane; calcium ion binding; detection of light stimulus involved in visual perception; epithelial fluid transport; exocytosis; high voltage-gated calcium channel activity; low voltage-gated calcium channel activity; male courtship behavior, veined wing generated song production; multicellular organismal development; neurotransmitter secretion; phototransduction; positive regulation of synaptic growth at neuromuscular junction; presynaptic active zone; regulation of heart rate; regulation of neurotransmitter secretion; visual behavior; voltage-gated calcium channel complex" IPR027359; IPR002048; IPR005821; IPR014873; IPR002077; Voltage-dependent calcium channel type A subunit alpha-1 (Protein cacophony) (Protein nightblind A) (Protein no-on-transient B) (Dmca1A) cac nbA nonB CG43368 Drosophila melanogaster (Fruit fly) TR9360_c0_g1_i1 A7MBE0 S22A1_BOVIN 3.00E-20 GO:0016323; GO:0016021; GO:0015101; GO:0015695 basolateral plasma membrane; integral to membrane; organic cation transmembrane transporter activity; organic cation transport IPR020846; IPR016196; IPR004749; IPR005828; IPR005829; Solute carrier family 22 member 1 (Organic cation transporter 1) SLC22A1 OCT1 Bos taurus (Bovine) TR9360_c2_g1_i1 Q2KIV1 S22A9_BOVIN 9.00E-10 GO:0016021; GO:0055085 integral to membrane; transmembrane transport IPR011701; IPR020846; IPR016196; Solute carrier family 22 member 9 (Organic anion transporter 4) SLC22A9 OAT4 Bos taurus (Bovine) TR9361_c0_g2_i1 Q0VAA2 CN16B_HUMAN 1.00E-10 Uncharacterized protein C14orf166B C14orf166B Homo sapiens (Human) TR9363_c0_g1_i1 P18503 CAS4_EPHMU 2.00E-11 GO:0005581 collagen IPR008160; Short-chain collagen C4 (Fragment) Ephydatia muelleri (Mueller's freshwater sponge) TR9371_c0_g1_i1 O76554 ACH4_CAEEL 2.00E-18 GO:0005230; GO:0005887 extracellular ligand-gated ion channel activity; integral to plasma membrane IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; Acetylcholine receptor subunit alpha-type des-2 des-2 acr-4 T26H10.1 Caenorhabditis elegans TR9376_c0_g1_i1 Q5ASQ0 PPIL1_EMENI 8.00E-52 GO:0003755; GO:0006457; GO:0000413 peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase-like 1 (PPIase) (EC 5.2.1.8) (Rotamase) cyp1 AN8680 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) TR9376_c0_g2_i1 Q9D0W5 PPIL1_MOUSE 1.00E-78 GO:0008380; GO:0071013; GO:0006397; GO:0003755; GO:0006457; GO:0000413 RNA splicing; catalytic step 2 spliceosome; mRNA processing; peptidyl-prolyl cis-trans isomerase activity; protein folding; protein peptidyl-prolyl isomerization IPR002130; IPR024936; IPR020892; Peptidyl-prolyl cis-trans isomerase-like 1 (PPIase) (EC 5.2.1.8) (Rotamase PPIL1) Ppil1 Mus musculus (Mouse) TR9379_c0_g1_i1 P20111 ACTN2_CHICK 7.00E-07 GO:0030018; GO:0005509; GO:0030175; GO:0005925; GO:0048041; GO:0030035; GO:0006936; GO:1901017; GO:0043267; GO:2000009; GO:1901018; GO:0043268; GO:0051289; GO:0042391; GO:0030375 Z disc; calcium ion binding; filopodium; focal adhesion; focal adhesion assembly; microspike assembly; muscle contraction; negative regulation of potassium ion transmembrane transporter activity; negative regulation of potassium ion transport; negative regulation of protein localization to cell surface; positive regulation of potassium ion transmembrane transporter activity; positive regulation of potassium ion transport; protein homotetramerization; regulation of membrane potential; thyroid hormone receptor coactivator activity IPR001589; IPR001715; IPR011992; IPR014837; IPR002048; IPR018159; IPR002017; Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) ACTN2 Gallus gallus (Chicken) TR9379_c0_g2_i1 P02595 CALM_PATSP 3.00E-29 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) Patinopecten sp. (Scallop) TR9386_c0_g1_i2 Q58455 Y1055_METJA 1.00E-95 GO:0005975; GO:0044237; GO:0050662; GO:0016829; GO:0016857 "carbohydrate metabolic process; cellular metabolic process; coenzyme binding; lyase activity; racemase and epimerase activity, acting on carbohydrates and derivatives" IPR001509; IPR016040; IPR008089; Uncharacterized protein MJ1055 MJ1055 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR9397_c0_g1_i1 P50882 RL9_DROME 8.00E-87 GO:0051298; GO:0000022; GO:0019843; GO:0005840; GO:0003735; GO:0006412 centrosome duplication; mitotic spindle elongation; rRNA binding; ribosome; structural constituent of ribosome; translation IPR000702; IPR020040; IPR002359; 60S ribosomal protein L9 RpL9 M(2)32D CG6141 Drosophila melanogaster (Fruit fly) TR9398_c0_g1_i1 Q6IPM2 IQCE_HUMAN 8.00E-12 GO:0005739 mitochondrion IPR000048; IQ domain-containing protein E IQCE KIAA1023 Homo sapiens (Human) TR9400_c0_g1_i1 Q80TE4 SI1L2_MOUSE 1.00E-09 GO:0005096; GO:0043547; GO:0051056 GTPase activator activity; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction IPR021818; IPR001478; IPR000331; Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) Sipa1l2 Kiaa0545 Mus musculus (Mouse) TR9401_c0_g1_i1 P46778 RL21_HUMAN 9.00E-77 GO:0003723; GO:0006614; GO:0022625; GO:0000184; GO:0003735; GO:0006414; GO:0006413; GO:0006415; GO:0019083 "RNA binding; SRP-dependent cotranslational protein targeting to membrane; cytosolic large ribosomal subunit; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; translational elongation; translational initiation; translational termination; viral transcription" IPR001147; IPR018259; IPR008991; 60S ribosomal protein L21 RPL21 Homo sapiens (Human) TR9406_c0_g1_i1 Q8NEG5 ZSWM2_HUMAN 2.00E-11 GO:0006915; GO:0000209; GO:0042981; GO:0004842; GO:0008270 apoptotic process; protein polyubiquitination; regulation of apoptotic process; ubiquitin-protein ligase activity; zinc ion binding IPR001841; IPR013083; IPR007527; IPR000433; E3 ubiquitin-protein ligase ZSWIM2 (EC 6.3.2.-) (MEKK1-related protein X) (MEX) (ZZ-type zinc finger-containing protein 2) (Zinc finger SWIM domain-containing protein 2) ZSWIM2 ZZZ2 Homo sapiens (Human) TR9412_c0_g1_i1 Q6P9A3 ZN549_HUMAN 9.00E-11 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 549 ZNF549 Homo sapiens (Human) TR9415_c1_g1_i1 Q6NYE4 ALKMO_DANRE 1.00E-47 GO:0005783; GO:0005789; GO:0046485; GO:0006633; GO:0050479; GO:0016021; GO:0005506; GO:0006643 endoplasmic reticulum; endoplasmic reticulum membrane; ether lipid metabolic process; fatty acid biosynthetic process; glyceryl-ether monooxygenase activity; integral to membrane; iron ion binding; membrane lipid metabolic process IPR006694; Alkylglycerol monooxygenase (EC 1.14.16.5) (Transmembrane protein 195) agmo tmem195 zgc:77121 Danio rerio (Zebrafish) (Brachydanio rerio) TR9416_c2_g1_i1 Q0VG85 CC162_MOUSE 1.00E-23 Coiled-coil domain-containing protein 162 (Protein CCDC162P) Ccdc162p Ccdc162 Mus musculus (Mouse) TR9417_c0_g1_i1 Q6INX1 TMM98_XENLA 2.00E-29 GO:0016021 integral to membrane Transmembrane protein 98 tmem98 Xenopus laevis (African clawed frog) TR9437_c0_g1_i1 Q57997 Y577_METJA 1.00E-06 GO:0005524; GO:0005737; GO:0006950 ATP binding; cytoplasm; response to stress IPR014729; IPR006015; IPR006016; Universal stress protein MJ0577 (USP MJ0577) MJ0577 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) TR9439_c0_g1_i1 Q924A2 CIC_MOUSE 4.00E-27 GO:0003677; GO:0005634; GO:0006355; GO:0006351 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR009071; Protein capicua homolog Cic Kiaa0306 Mus musculus (Mouse) TR9440_c0_g1_i1 Q8HXQ5 MRP1_BOVIN 5.00E-11 GO:0005524; GO:0006200; GO:0042626; GO:0016021; GO:0005886 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; plasma membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP1 Bos taurus (Bovine) TR9440_c2_g1_i1 Q5F364 MRP1_CHICK 7.00E-29 GO:0005524; GO:0006200; GO:0042626; GO:0016021; GO:0005886 "ATP binding; ATP catabolic process; ATPase activity, coupled to transmembrane movement of substances; integral to membrane; plasma membrane" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP1 RCJMB04_32d20 Gallus gallus (Chicken) TR9441_c0_g1_i1 P18503 CAS4_EPHMU 8.00E-11 GO:0005581 collagen IPR008160; Short-chain collagen C4 (Fragment) Ephydatia muelleri (Mueller's freshwater sponge) TR9443_c0_g1_i1 P15620 ZN271_MOUSE 6.00E-79 GO:0003677; GO:0030154; GO:0002437; GO:0046872; GO:0007275; GO:0045629; GO:0002829; GO:0005634; GO:0006355; GO:0007283; GO:0006351 "DNA binding; cell differentiation; inflammatory response to antigenic stimulus; metal ion binding; multicellular organismal development; negative regulation of T-helper 2 cell differentiation; negative regulation of type 2 immune response; nucleus; regulation of transcription, DNA-dependent; spermatogenesis; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 271 (Zinc finger protein 35) (Zfp-35) Znf271 Zfp-35 Zfp35 Mus musculus (Mouse) TR9446_c1_g1_i1 Q6UVM4 KCNT2_RAT 2.00E-23 GO:0005524; GO:0015269; GO:0005228; GO:0005249; GO:0008076 ATP binding; calcium-activated potassium channel activity; intracellular sodium activated potassium channel activity; voltage-gated potassium channel activity; voltage-gated potassium channel complex IPR013099; IPR003929; IPR016040; Potassium channel subfamily T member 2 (Sequence like an intermediate conductance potassium channel subunit) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1) Kcnt2 Slick Rattus norvegicus (Rat) TR9450_c0_g1_i1 Q8C7M3 TRIM9_MOUSE 2.00E-07 GO:0030054; GO:0005737; GO:0005856; GO:0030425; GO:0043161; GO:0008021; GO:0004842; GO:0008270 cell junction; cytoplasm; cytoskeleton; dendrite; proteasomal ubiquitin-dependent protein catabolic process; synaptic vesicle; ubiquitin-protein ligase activity; zinc ion binding IPR001870; IPR003649; IPR008985; IPR017903; IPR003961; IPR013783; IPR003877; IPR000315; IPR018957; IPR001841; IPR013083; IPR017907; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase TRIM9 (EC 6.3.2.-) (Tripartite motif-containing protein 9) Trim9 Kiaa0282 Mus musculus (Mouse) TR9457_c0_g1_i1 Q9BX70 BTBD2_HUMAN 8.00E-26 GO:0000932 Q7L5N1; P04637 cytoplasmic mRNA processing body IPR011705; IPR000210; IPR011333; IPR013069; IPR012983; BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) TR9458_c1_g1_i1 Q6XUX0 DUSTY_CHICK 8.00E-10 GO:0005524; GO:0005737; GO:0018108; GO:0004674; GO:0004712; GO:0004713 ATP binding; cytoplasm; peptidyl-tyrosine phosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (Receptor-interacting serine/threonine-protein kinase 5) DSTYK RIPK5 Gallus gallus (Chicken) TR9459_c0_g2_i1 O88322 NID2_MOUSE 4.00E-13 GO:0005604; GO:0005509; GO:0009986; GO:0007160 basement membrane; calcium ion binding; cell surface; cell-matrix adhesion IPR011042; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR000033; IPR003886; IPR000716; Nidogen-2 (NID-2) (Entactin-2) Nid2 Mus musculus (Mouse) TR9459_c0_g3_i1 O75581 LRP6_HUMAN 8.00E-14 GO:0044332; GO:0021874; GO:0090244; GO:0042813; GO:0034185; GO:0090245; GO:0060349; GO:0046849; GO:0060444; GO:0061310; GO:0044335; GO:0061324; GO:0044340; GO:0042074; GO:0009986; GO:0071397; GO:0021587; GO:0021795; GO:0021987; GO:0060026; GO:0071936; GO:0031410; GO:0071542; GO:0005769; GO:0048596; GO:0042733; GO:0035115; GO:0035116; GO:0030326; GO:0009880; GO:0060059; GO:0005783; GO:0035261; GO:0060325; GO:0021861; GO:0021943; GO:0001947; GO:0016021; GO:0019210; GO:0005041; GO:0060596; GO:0030901; GO:0030917; GO:0050680; GO:0045599; GO:2000151; GO:2000162; GO:2000168; GO:2000164; GO:2000166; GO:2000149; GO:0071901; GO:0034392; GO:0014029; GO:0001843; GO:0043025; GO:0042475; GO:0060021; GO:0003344; GO:0005886; GO:2000055; GO:0043065; GO:0045780; GO:0090263; GO:0045787; GO:0002053; GO:0045778; GO:0051091; GO:0045944; GO:0036342; GO:0090009; GO:0043235; GO:0090118; GO:0060284; GO:0045598; GO:0030278; GO:0051593; GO:0045202; GO:0007268; GO:0021794; GO:0019534; GO:0060535 Q9Y4X0; Q9H6X2; O70239; Q03135; P98082; P49840; P49841; Q5S007; Q9ERE8 Wnt receptor signaling pathway involved in dorsal/ventral axis specification; Wnt receptor signaling pathway involved in forebrain neuroblast division; Wnt receptor signaling pathway involved in somitogenesis; Wnt-activated receptor activity; apolipoprotein binding; axis elongation involved in somitogenesis; bone morphogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development; canonical Wnt receptor signaling pathway involved in neural crest cell differentiation; canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; canonical Wnt receptor signaling pathway involved in regulation of cell proliferation; cell migration involved in gastrulation; cell surface; cellular response to cholesterol; cerebellum morphogenesis; cerebral cortex cell migration; cerebral cortex development; convergent extension; coreceptor activity involved in Wnt receptor signaling pathway; cytoplasmic vesicle; dopaminergic neuron differentiation; early endosome; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; embryonic pattern specification; embryonic retina morphogenesis in camera-type eye; endoplasmic reticulum; external genitalia morphogenesis; face morphogenesis; forebrain radial glial cell differentiation; formation of radial glial scaffolds; heart looping; integral to membrane; kinase inhibitor activity; low-density lipoprotein receptor activity; mammary placode formation; midbrain development; midbrain-hindbrain boundary development; negative regulation of epithelial cell proliferation; negative regulation of fat cell differentiation; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis; negative regulation of planar cell polarity pathway involved in neural tube closure; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest formation; neural tube closure; neuronal cell body; odontogenesis of dentin-containing tooth; palate development; pericardium morphogenesis; plasma membrane; positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of canonical Wnt receptor signaling pathway; positive regulation of cell cycle; positive regulation of mesenchymal cell proliferation; positive regulation of ossification; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; post-anal tail morphogenesis; primitive streak formation; receptor complex; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport; regulation of cell development; regulation of fat cell differentiation; regulation of ossification; response to folic acid; synapse; synaptic transmission; thalamus development; toxin transporter activity; trachea cartilage morphogenesis IPR011042; IPR000742; IPR023415; IPR000033; IPR002172; IPR017049; Low-density lipoprotein receptor-related protein 6 (LRP-6) LRP6 Homo sapiens (Human) TR946_c0_g1_i1 O43315 AQP9_HUMAN 1.00E-32 GO:0005275; GO:0016323; GO:0015722; GO:0046943; GO:0071320; GO:0007588; GO:0015254; GO:0006955; GO:0005887; GO:0043231; GO:0008152; GO:0015288; GO:0005345; GO:0005350; GO:0046689; GO:0006970; GO:0015250; GO:0030104 amine transmembrane transporter activity; basolateral plasma membrane; canalicular bile acid transport; carboxylic acid transmembrane transporter activity; cellular response to cAMP; excretion; glycerol channel activity; immune response; integral to plasma membrane; intracellular membrane-bounded organelle; metabolic process; porin activity; purine nucleobase transmembrane transporter activity; pyrimidine nucleobase transmembrane transporter activity; response to mercury ion; response to osmotic stress; water channel activity; water homeostasis IPR023271; IPR015685; IPR000425; IPR022357; Aquaporin-9 (AQP-9) (Aquaglyceroporin-9) (Small solute channel 1) AQP9 SSC1 Homo sapiens (Human) TR9467_c0_g1_i1 Q9VZZ4 PXDN_DROME 5.00E-07 GO:0030198; GO:0020037; GO:0042744; GO:0046872; GO:0004601; GO:0006909; GO:0005578 extracellular matrix organization; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity; phagocytosis; proteinaceous extracellular matrix IPR010255; IPR002007; IPR019791; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR003591; IPR000372; IPR001007; Peroxidasin (EC 1.11.1.7) Pxn CG12002 Drosophila melanogaster (Fruit fly) TR9469_c0_g2_i1 Q9WVR6 LAT2_RAT 4.00E-06 GO:0015179; GO:0015171; GO:0016323; GO:0005737; GO:0016021; GO:0015804; GO:0015101; GO:0042605; GO:0019534 L-amino acid transmembrane transporter activity; amino acid transmembrane transporter activity; basolateral plasma membrane; cytoplasm; integral to membrane; neutral amino acid transport; organic cation transmembrane transporter activity; peptide antigen binding; toxin transporter activity IPR002293; IPR004760; Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (Solute carrier family 7 member 8) Slc7a8 Lat2 Lat4 Rattus norvegicus (Rat) TR9490_c1_g1_i1 Q96DM1 PGBD4_HUMAN 4.00E-06 PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) TR9494_c0_g1_i1 P09810 TPH1_RAT 2.00E-06 GO:0016597; GO:0046849; GO:0007623; GO:0005737; GO:0005506; GO:0060749; GO:0030279; GO:0043005; GO:0035902; GO:0006587; GO:0004510 amino acid binding; bone remodeling; circadian rhythm; cytoplasm; iron ion binding; mammary gland alveolus development; negative regulation of ossification; neuron projection; response to immobilization stress; serotonin biosynthetic process from tryptophan; tryptophan 5-monooxygenase activity IPR002912; IPR001273; IPR018301; IPR019774; IPR005963; IPR019773; Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2. Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1) Tph1 Tph Rattus norvegicus (Rat) TR9498_c0_g1_i1 Q8MRC9 GALT9_DROME 2.00E-10 GO:0000139; GO:0016021; GO:0032504; GO:0004653; GO:0006486 Golgi membrane; integral to membrane; multicellular organism reproduction; polypeptide N-acetylgalactosaminyltransferase activity; protein glycosylation IPR001173; IPR000772; Protein modification; protein glycosylation. Putative polypeptide N-acetylgalactosaminyltransferase 9 (pp-GaNTase 9) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 9) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 9) pgant9 CG30463 Drosophila melanogaster (Fruit fly) TR9507_c0_g1_i1 A2AN08 UBR4_MOUSE 1.00E-06 GO:0005737; GO:0005856; GO:0016021; GO:0005634; GO:0042787; GO:0004842; GO:0008270 P06933 cytoplasm; cytoskeleton; integral to membrane; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity; zinc ion binding IPR016024; IPR025704; IPR017986; IPR003126; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase UBR4 (EC 6.3.2.-) (N-recognin-4) (Zinc finger UBR1-type protein 1) (p600) Ubr4 Kiaa0462 Zubr1 Mus musculus (Mouse) TR9511_c0_g1_i1 O43301 HS12A_HUMAN 4.00E-42 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR9537_c0_g1_i1 P97386 DNLI3_MOUSE 1.00E-12 GO:0005524; GO:0003677; GO:0003910; GO:0006266; GO:0051103; GO:0006310; GO:0006260; GO:0007049; GO:0051301; GO:0005694; GO:0006303; GO:0006273; GO:0043504; GO:0045910; GO:0006289; GO:0005634; GO:0000795; GO:0008270 ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligation; DNA ligation involved in DNA repair; DNA recombination; DNA replication; cell cycle; cell division; chromosome; double-strand break repair via nonhomologous end joining; lagging strand elongation; mitochondrial DNA repair; negative regulation of DNA recombination; nucleotide-excision repair; nucleus; synaptonemal complex; zinc ion binding IPR001357; IPR000977; IPR012309; IPR012310; IPR016059; IPR012308; IPR012340; IPR001510; DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) Lig3 Mus musculus (Mouse) TR9537_c0_g1_i2 P97386 DNLI3_MOUSE 1.00E-11 GO:0005524; GO:0003677; GO:0003910; GO:0006266; GO:0051103; GO:0006310; GO:0006260; GO:0007049; GO:0051301; GO:0005694; GO:0006303; GO:0006273; GO:0043504; GO:0045910; GO:0006289; GO:0005634; GO:0000795; GO:0008270 ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligation; DNA ligation involved in DNA repair; DNA recombination; DNA replication; cell cycle; cell division; chromosome; double-strand break repair via nonhomologous end joining; lagging strand elongation; mitochondrial DNA repair; negative regulation of DNA recombination; nucleotide-excision repair; nucleus; synaptonemal complex; zinc ion binding IPR001357; IPR000977; IPR012309; IPR012310; IPR016059; IPR012308; IPR012340; IPR001510; DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) Lig3 Mus musculus (Mouse) TR9542_c0_g1_i1 Q924X7 STK33_MOUSE 2.00E-06 GO:0005524; GO:0048471; GO:0046777; GO:0004674 ATP binding; perinuclear region of cytoplasm; protein autophosphorylation; protein serine/threonine kinase activity IPR020636; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase 33 (EC 2.7.11.1) Stk33 Mus musculus (Mouse) TR9544_c0_g1_i1 P61917 NPC2_PANTR 1.00E-16 GO:0015485; GO:0033344; GO:0042632; GO:0008203; GO:0005783; GO:0005576; GO:0032367; GO:0005764; GO:0009615 cholesterol binding; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; endoplasmic reticulum; extracellular region; intracellular cholesterol transport; lysosome; response to virus IPR014756; IPR003172; Epididymal secretory protein E1 (EPI-1) (Niemann Pick type C2 protein homolog) NPC2 Pan troglodytes (Chimpanzee) TR955_c0_g1_i1 Q5EAR5 TRPT1_DANRE 1.00E-09 GO:0000215; GO:0006388 "tRNA 2'-phosphotransferase activity; tRNA splicing, via endonucleolytic cleavage and ligation" IPR002745; tRNA 2'-phosphotransferase 1 (EC 2.7.1.160) trpt1 zgc:113138 Danio rerio (Zebrafish) (Brachydanio rerio) TR9550_c1_g1_i1 P57071 PRD15_HUMAN 1.00E-16 GO:0003677; GO:0046872; GO:0008168; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; methyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001214; IPR007087; IPR015880; IPR013087; PR domain zinc finger protein 15 (EC 2.1.1.-) (PR domain-containing protein 15) (Zinc finger protein 298) PRDM15 C21orf83 ZNF298 Homo sapiens (Human) TR9550_c4_g1_i1 Q9NQV6 PRD10_HUMAN 2.00E-37 GO:0003677; GO:0046872; GO:0008168; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; methyltransferase activity; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; IPR022755; PR domain zinc finger protein 10 (EC 2.1.1.-) (PR domain-containing protein 10) (Tristanin) PRDM10 KIAA1231 PFM7 TRIS Homo sapiens (Human) TR9554_c0_g1_i1 Q3MII6 TBC25_HUMAN 2.00E-28 GO:0005097; GO:0005776; GO:0006914; GO:0031410; GO:1901096 Rab GTPase activator activity; autophagic vacuole; autophagy; cytoplasmic vesicle; regulation of autophagic vacuole maturation IPR000195; TBC1 domain family member 25 TBC1D25 OATL1 Homo sapiens (Human) TR9555_c0_g1_i1 Q1LXZ7 IQCH_DANRE 2.00E-09 IPR000048; IQ motif-containing protein H iqch si:dkey-246a16.2 Danio rerio (Zebrafish) (Brachydanio rerio) TR9590_c0_g1_i1 Q0EEE2 PTHD3_MOUSE 1.00E-37 GO:0008158; GO:0016021 hedgehog receptor activity; integral to membrane IPR003392; IPR000731; Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) TR9590_c1_g1_i1 Q09614 PTC1_CAEEL 8.00E-10 GO:0051301; GO:0008158; GO:0005887; GO:0007067; GO:0018996 "cell division; hedgehog receptor activity; integral to plasma membrane; mitosis; molting cycle, collagen and cuticulin-based cuticle" IPR003392; IPR000731; Protein patched homolog 1 ptc-1 ZK675.1 Caenorhabditis elegans TR9593_c0_g2_i1 Q8WU20 FRS2_HUMAN 8.00E-18 GO:0038095; GO:0007186; GO:0000187; GO:0000186; GO:0008595; GO:0012505; GO:0005768; GO:0007173; GO:0008543; GO:0030900; GO:0001702; GO:0045087; GO:0008286; GO:0005887; GO:0007405; GO:0048011; GO:0046619; GO:0001759; GO:0019211; GO:0048015; GO:0060527; GO:0050678; GO:0005068; GO:0007185; GO:0003281 "Fc-epsilon receptor signaling pathway; G-protein coupled receptor signaling pathway; activation of MAPK activity; activation of MAPKK activity; anterior/posterior axis specification, embryo; endomembrane system; endosome; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; forebrain development; gastrulation with mouth forming second; innate immune response; insulin receptor signaling pathway; integral to plasma membrane; neuroblast proliferation; neurotrophin TRK receptor signaling pathway; optic placode formation involved in camera-type eye formation; organ induction; phosphatase activator activity; phosphatidylinositol-mediated signaling; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; regulation of epithelial cell proliferation; transmembrane receptor protein tyrosine kinase adaptor activity; transmembrane receptor protein tyrosine phosphatase signaling pathway; ventricular septum development" IPR002404; IPR011993; Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) FRS2 Homo sapiens (Human) TR9618_c0_g1_i1 D4AQV3 VPS10_ARTBC 4.00E-13 GO:0005794; GO:0016021; GO:0031902; GO:0015031 Golgi apparatus; integral to membrane; late endosome membrane; protein transport IPR006581; Vacuolar protein sorting/targeting protein 10 (Carboxypeptidase Y receptor) (CPY receptor) (Sortilin VPS10) (Vacuolar carboxypeptidase sorting receptor VPS10) VPS10 ARB_06613 Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) TR9618_c2_g1_i1 Q96PQ0 SORC2_HUMAN 3.00E-13 GO:0016021; GO:0016020; GO:0008188 integral to membrane; membrane; neuropeptide receptor activity IPR022409; IPR000601; IPR006581; VPS10 domain-containing receptor SorCS2 SORCS2 KIAA1329 Homo sapiens (Human) TR9619_c0_g1_i1 Q8IVV2 LOXH1_HUMAN 5.00E-09 GO:0005262; GO:0050982; GO:0016020; GO:0007605; GO:0032420 calcium channel activity; detection of mechanical stimulus; membrane; sensory perception of sound; stereocilium IPR008976; IPR001024; Lipoxygenase homology domain-containing protein 1 LOXHD1 Homo sapiens (Human) TR9621_c0_g1_i1 Q8TE73 DYH5_HUMAN 3.00E-32 GO:0005524; GO:0006200; GO:0016887; GO:0005858; GO:0001539; GO:0035085; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; axonemal dynein complex; ciliary or bacterial-type flagellar motility; cilium axoneme; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 5, axonemal (Axonemal beta dynein heavy chain 5) (Ciliary dynein heavy chain 5)" DNAH5 DNAHC5 HL1 KIAA1603 Homo sapiens (Human) TR9621_c1_g1_i1 Q91XQ0 DYH8_MOUSE 2.00E-41 GO:0005524; GO:0006200; GO:0016887; GO:0035085; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018; GO:0031514 ATP binding; ATP catabolic process; ATPase activity; cilium axoneme; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement; motile cilium IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain 8, axonemal (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8)" Dnahc8 Mus musculus (Mouse) TR9621_c2_g1_i1 P45443 DYHC_NEUCR 1.00E-09 GO:0005524; GO:0006200; GO:0016887; GO:0005737; GO:0030286; GO:0005874; GO:0003777; GO:0007018 ATP binding; ATP catabolic process; ATPase activity; cytoplasm; dynein complex; microtubule; microtubule motor activity; microtubule-based movement IPR003593; IPR011704; IPR026983; IPR024743; IPR024317; IPR004273; IPR013594; IPR013602; IPR027417; "Dynein heavy chain, cytoplasmic (Dynein heavy chain, cytosolic) (DYHC)" ro-1 NCU06976 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR9629_c0_g1_i1 Q20390 PPT1_CAEEL 5.00E-13 GO:0044257; GO:0006464; GO:0005764; GO:0007005; GO:0018991; GO:0008474; GO:0009791 cellular protein catabolic process; cellular protein modification process; lysosome; mitochondrion organization; oviposition; palmitoyl-(protein) hydrolase activity; post-embryonic development IPR002472; Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1) ppt-1 F44C4.5 Caenorhabditis elegans TR9639_c0_g1_i1 A8XCP3 SODC_CAEBR 6.00E-20 GO:0005737; GO:0046872; GO:0042803; GO:0060378; GO:0004784; GO:0006801 cytoplasm; metal ion binding; protein homodimerization activity; regulation of brood size; superoxide dismutase activity; superoxide metabolic process IPR024134; IPR018152; IPR001424; Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) sod-1 CBG11197 Caenorhabditis briggsae TR964_c0_g1_i1 Q09225 NRF6_CAEEL 5.00E-13 GO:0016021; GO:0008289; GO:0006869; GO:0007275; GO:0016747 "integral to membrane; lipid binding; lipid transport; multicellular organismal development; transferase activity, transferring acyl groups other than amino-acyl groups" IPR002656; IPR006621; Nose resistant to fluoxetine protein 6 (Protein nrf-6) nrf-6 C08B11.4 Caenorhabditis elegans TR9650_c1_g2_i1 Q8WVS4 WDR60_HUMAN 2.00E-11 GO:0005929 cilium IPR015943; IPR001680; IPR017986; WD repeat-containing protein 60 WDR60 Homo sapiens (Human) TR9655_c0_g1_i1 Q92887 MRP2_HUMAN 9.00E-26 GO:0005524; GO:0042626; GO:0016324; GO:0030644; GO:0006855; GO:0005887; GO:0046581; GO:0008514; GO:0015732; GO:0046685; GO:0009408; GO:0031427; GO:0006979; GO:0070327 P19838 "ATP binding; ATPase activity, coupled to transmembrane movement of substances; apical plasma membrane; cellular chloride ion homeostasis; drug transmembrane transport; integral to plasma membrane; intercellular canaliculus; organic anion transmembrane transporter activity; prostaglandin transport; response to arsenic-containing substance; response to heat; response to methotrexate; response to oxidative stress; thyroid hormone transport" IPR003593; IPR011527; IPR003439; IPR017871; IPR001140; IPR005292; IPR027417; Canalicular multispecific organic anion transporter 1 (ATP-binding cassette sub-family C member 2) (Canalicular multidrug resistance protein) (Multidrug resistance-associated protein 2) ABCC2 CMOAT CMOAT1 CMRP MRP2 Homo sapiens (Human) TR9665_c0_g1_i1 Q9Y485 DMXL1_HUMAN 2.00E-29 IPR022033; IPR015943; IPR001680; IPR017986; DmX-like protein 1 (X-like 1 protein) DMXL1 XL1 Homo sapiens (Human) TR9685_c0_g1_i1 P05180 CP2H1_CHICK 2.00E-09 GO:0070330; GO:0005789; GO:0020037; GO:0005506 aromatase activity; endoplasmic reticulum membrane; heme binding; iron ion binding IPR001128; IPR017972; IPR002401; Cytochrome P450 2H1 (EC 1.14.14.1) (CYPIIH1) (Cytochrome P450 PB15) (Cytochrome P450 PCHP3) CYP2H1 Gallus gallus (Chicken) TR9698_c1_g1_i1 Q5RHP9 CA173_HUMAN 1.00E-11 IPR027962; Uncharacterized protein C1orf173 C1orf173 Homo sapiens (Human) TR9701_c0_g1_i1 Q66HF1 NDUS1_RAT 2.00E-37 GO:0051537; GO:0051539; GO:0046034; GO:0042773; GO:0008137; GO:0008637; GO:0045333; GO:0009055; GO:0046872; GO:0005758; GO:0005747; GO:0072593; GO:0051881 "2 iron, 2 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; ATP metabolic process; ATP synthesis coupled electron transport; NADH dehydrogenase (ubiquinone) activity; apoptotic mitochondrial changes; cellular respiration; electron carrier activity; metal ion binding; mitochondrial intermembrane space; mitochondrial respiratory chain complex I; reactive oxygen species metabolic process; regulation of mitochondrial membrane potential" IPR001041; IPR012675; IPR006656; IPR000283; IPR010228; IPR019574; IPR015405; "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3)" Ndufs1 Rattus norvegicus (Rat) TR9707_c0_g1_i1 Q9EQZ6 RPGF4_MOUSE 9.00E-06 GO:0005088; GO:0030552; GO:0005952; GO:0008603; GO:0019933; GO:0017156; GO:0005829; GO:0030073; GO:0016020; GO:0017157; GO:0051056; GO:0007264 P01112 Ras guanyl-nucleotide exchange factor activity; cAMP binding; cAMP-dependent protein kinase complex; cAMP-dependent protein kinase regulator activity; cAMP-mediated signaling; calcium ion-dependent exocytosis; cytosol; insulin secretion; membrane; regulation of exocytosis; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR002373; IPR018490; IPR000595; IPR000591; IPR000651; IPR019804; IPR008937; IPR023578; IPR001895; IPR014710; IPR011991; Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) Rapgef4 Cgef2 Epac2 Mus musculus (Mouse) TR9708_c0_g1_i1 Q96K62 ZBT45_HUMAN 1.00E-14 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR000210; IPR011333; IPR013069; IPR007087; IPR015880; IPR013087; Zinc finger and BTB domain-containing protein 45 (Zinc finger protein 499) ZBTB45 ZNF499 Homo sapiens (Human) TR9708_c0_g2_i1 Q3KQV3 ZN792_HUMAN 5.00E-21 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 792 ZNF792 Homo sapiens (Human) TR9713_c0_g1_i1 P14381 YTX2_XENLA 1.00E-06 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; Transposon TX1 uncharacterized 149 kDa protein (ORF 2) Xenopus laevis (African clawed frog) TR9719_c0_g1_i1 P62309 RUXG_MOUSE 8.00E-30 GO:0003723; GO:0008380; GO:0005689; GO:0005683; GO:0071013; GO:0006397 RNA binding; RNA splicing; U12-type spliceosomal complex; U7 snRNP; catalytic step 2 spliceosome; mRNA processing IPR010920; IPR001163; IPR006649; Small nuclear ribonucleoprotein G (snRNP-G) (Sm protein G) (Sm-G) (SmG) Snrpg Mus musculus (Mouse) TR9723_c1_g1_i1 Q9Y253 POLH_HUMAN 3.00E-08 GO:0006260; GO:0000731; GO:0003887; GO:0005737; GO:0003684; GO:0046872; GO:0005654; GO:0006301; GO:0006290; GO:0006282; GO:0010225 Q6FI35; P0CG48 DNA replication; DNA synthesis involved in DNA repair; DNA-directed DNA polymerase activity; cytoplasm; damaged DNA binding; metal ion binding; nucleoplasm; postreplication repair; pyrimidine dimer repair; regulation of DNA repair; response to UV-C IPR017061; IPR017961; IPR001126; IPR017963; DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) POLH RAD30 RAD30A XPV Homo sapiens (Human) TR9736_c1_g1_i1 P48605 TCPG_DROME 2.00E-46 GO:0005524; GO:0042623; GO:0005832; GO:0005875; GO:0007052; GO:0006457; GO:0007430; GO:0060439 "ATP binding; ATPase activity, coupled; chaperonin-containing T-complex; microtubule associated complex; mitotic spindle organization; protein folding; terminal branching, open tracheal system; trachea morphogenesis" IPR012719; IPR017998; IPR002194; IPR002423; IPR027409; IPR027413; IPR027410; T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) Cctgamma CCT-3 Cctg CG8977 Drosophila melanogaster (Fruit fly) TR9742_c1_g1_i1 Q8ISN9 RS25_BRABE 8.00E-40 GO:0005840 ribosome IPR004977; 40S ribosomal protein S25 RPS25 Branchiostoma belcheri (Amphioxus) TR9743_c1_g1_i1 Q6TFL3 CC171_HUMAN 1.00E-22 Coiled-coil domain-containing protein 171 CCDC171 C9orf93 Homo sapiens (Human) TR9753_c1_g1_i1 P17081 RHOQ_HUMAN 9.00E-08 GO:0005525; GO:0003924; GO:0005884; GO:0030866; GO:0005829; GO:0008286; GO:0045121; GO:0090005; GO:0005886; GO:0051491; GO:0046326; GO:0045944; GO:0032956; GO:0008360; GO:0051056; GO:0007264 GTP binding; GTPase activity; actin filament; cortical actin cytoskeleton organization; cytosol; insulin receptor signaling pathway; membrane raft; negative regulation of establishment of protein localization to plasma membrane; plasma membrane; positive regulation of filopodium assembly; positive regulation of glucose import; positive regulation of transcription from RNA polymerase II promoter; regulation of actin cytoskeleton organization; regulation of cell shape; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A) RHOQ ARHQ RASL7A TC10 Homo sapiens (Human) TR9754_c1_g1_i1 O95153 RIMB1_HUMAN 4.00E-33 GO:0005739 O00555 mitochondrion IPR003961; IPR011511; IPR001452; Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIMS-binding protein 1) (RIM-BP1) BZRAP1 KIAA0612 RBP1 RIMBP1 Homo sapiens (Human) TR9757_c1_g1_i1 Q5ND56 FA57A_MOUSE 1.00E-23 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR006634; Protein FAM57A Fam57a Mus musculus (Mouse) TR9759_c1_g1_i1 Q8VHX6 FLNC_MOUSE 2.00E-20 GO:0030018; GO:0003779; GO:0015629; GO:0030029; GO:0048747; GO:0042383 Z disc; actin binding; actin cytoskeleton; actin filament-based process; muscle fiber development; sarcolemma IPR001589; IPR001715; IPR003961; IPR001298; IPR017868; IPR013783; IPR014756; Filamin-C (FLN-C) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Flnc Abpl Fln2 Mus musculus (Mouse) TR9762_c2_g1_i1 Q9V9A8 PHTF_DROME 3.00E-26 GO:0003677; GO:0005634; GO:0046983; GO:0006357; GO:0003700; GO:0006351 "DNA binding; nucleus; protein dimerization activity; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR021980; Putative homeodomain transcription factor phtf CG3268 Drosophila melanogaster (Fruit fly) TR9769_c0_g1_i1 P86881 NGB_DISMA 6.00E-12 GO:0005737; GO:0020037; GO:0005506; GO:0019825; GO:0005344; GO:0043204 cytoplasm; heme binding; iron ion binding; oxygen binding; oxygen transporter activity; perikaryon IPR000971; IPR009050; IPR012292; IPR001032; Neuroglobin Dissostichus mawsoni (Antarctic cod) TR9774_c0_g1_i1 Q9DAK9 PHP14_MOUSE 1.00E-35 GO:0019855; GO:0005829; GO:2000984; GO:0050860; GO:0051350; GO:0035971; GO:0008969; GO:0004721; GO:2000147; GO:2000249 calcium channel inhibitor activity; cytosol; negative regulation of ATP citrate synthase activity; negative regulation of T cell receptor signaling pathway; negative regulation of lyase activity; peptidyl-histidine dephosphorylation; phosphohistidine phosphatase activity; phosphoprotein phosphatase activity; positive regulation of cell motility; regulation of actin cytoskeleton reorganization IPR007702; 14 kDa phosphohistidine phosphatase (EC 3.1.3.-) (Phosphohistidine phosphatase 1) Phpt1 Php14 Mus musculus (Mouse) TR9775_c0_g2_i1 Q03958 PFD6_MOUSE 2.00E-07 GO:0051131; GO:0005634; GO:0016272; GO:0006457 chaperone-mediated protein complex assembly; nucleus; prefoldin complex; protein folding IPR002777; IPR009053; Prefoldin subunit 6 (Protein Ke2) Pfdn6 H2-Ke2 Pfd6 Mus musculus (Mouse) TR9780_c0_g1_i1 Q03278 PO21_NASVI 2.00E-11 GO:0003723; GO:0006278; GO:0003964; GO:0004519; GO:0046872; GO:0090305 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; endonuclease activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis IPR000477; IPR007087; IPR015880; Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 (Retrovirus-related Pol polyprotein from type I retrotransposable element R2) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] (Fragment) Nasonia vitripennis (Parasitic wasp) TR9782_c0_g1_i1 P00430 COX7C_BOVIN 2.00E-14 GO:0004129; GO:0016021; GO:0005743; GO:0045277 cytochrome-c oxidase activity; integral to membrane; mitochondrial inner membrane; respiratory chain complex IV IPR004202; "Cytochrome c oxidase subunit 7C, mitochondrial (Cytochrome c oxidase polypeptide VIIIA) (Cytochrome c oxidase polypeptide VIIc)" COX7C COX7CP1 Bos taurus (Bovine) TR9784_c0_g1_i1 Q6V0I7 FAT4_HUMAN 2.00E-11 GO:0005509; GO:0007156; GO:0016021; GO:0005886 Q9H2K2 calcium ion binding; homophilic cell adhesion; integral to membrane; plasma membrane IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR009030; IPR001791; Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) TR9784_c1_g1_i1 Q9V5N8 STAN_DROME 3.00E-33 GO:0004930; GO:0007464; GO:0048057; GO:0016055; GO:0007411; GO:0005509; GO:0016339; GO:0050839; GO:0005911; GO:0048813; GO:0070593; GO:0007156; GO:0005887; GO:0016319; GO:0030178; GO:0007218; GO:0016318; GO:0030177; GO:0005057; GO:0050770; GO:0090175; GO:0051963; GO:0035159; GO:0007367; GO:0004888 P18537 "G-protein coupled receptor activity; R3/R4 cell fate commitment; R3/R4 development; Wnt receptor signaling pathway; axon guidance; calcium ion binding; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; cell-cell junction; dendrite morphogenesis; dendrite self-avoidance; homophilic cell adhesion; integral to plasma membrane; mushroom body development; negative regulation of Wnt receptor signaling pathway; neuropeptide signaling pathway; ommatidial rotation; positive regulation of Wnt receptor signaling pathway; receptor signaling protein activity; regulation of axonogenesis; regulation of establishment of planar polarity; regulation of synapse assembly; regulation of tube length, open tracheal system; segment polarity determination; transmembrane signaling receptor activity" IPR002126; IPR015919; IPR020894; IPR008985; IPR013320; IPR022624; IPR000742; IPR001881; IPR013032; IPR002049; IPR017981; IPR001879; IPR000832; IPR000203; IPR001791; Protocadherin-like wing polarity protein stan (Protein flamingo) (Protein starry night) stan fmi CG11895 Drosophila melanogaster (Fruit fly) TR9786_c0_g1_i1 P53815 SSRA_RABIT 4.00E-52 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR005595; Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) SSR1 Oryctolagus cuniculus (Rabbit) TR9790_c0_g1_i1 Q53GL7 PAR10_HUMAN 7.00E-30 GO:0005794; GO:0003950; GO:0048147; GO:0005634; GO:0070212; GO:0010847 Q9Y530 Golgi apparatus; NAD+ ADP-ribosyltransferase activity; negative regulation of fibroblast proliferation; nucleus; protein poly-ADP-ribosylation; regulation of chromatin assembly IPR012317; IPR003903; Poly [ADP-ribose] polymerase 10 (PARP-10) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) PARP10 Homo sapiens (Human) TR9794_c0_g1_i1 P91443 HUM6_CAEEL 9.00E-25 GO:0005524; GO:0005737; GO:0003774; GO:0031476; GO:0007165 ATP binding; cytoplasm; motor activity; myosin VI complex; signal transduction IPR019749; IPR014352; IPR019748; IPR000299; IPR018979; IPR000048; IPR001609; IPR000857; IPR027417; IPR011993; Unconventional myosin heavy chain 6 hum-6 T10H10.1 Caenorhabditis elegans TR9795_c0_g1_i1 Q7TQP6 TNI3K_RAT 5.00E-13 GO:0005524; GO:0005737; GO:0046872; GO:0005634; GO:0004674 ATP binding; cytoplasm; metal ion binding; nucleus; protein serine/threonine kinase activity IPR002110; IPR020683; IPR011009; IPR000719; IPR017441; IPR001245; Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (TNNI3-interacting kinase) Tnni3k Cark Rattus norvegicus (Rat) TR9795_c1_g1_i1 Q5DW34 EHMT1_MOUSE 4.00E-18 GO:0006306; GO:0005694; GO:0009790; GO:0046976; GO:0046974; GO:0000122; GO:0005634; GO:0018027; GO:0018026; GO:0008270 DNA methylation; chromosome; embryo development; histone methyltransferase activity (H3-K27 specific); histone methyltransferase activity (H3-K9 specific); negative regulation of transcription from RNA polymerase II promoter; nucleus; peptidyl-lysine dimethylation; peptidyl-lysine monomethylation; zinc ion binding IPR002110; IPR020683; IPR007728; IPR003606; IPR001214; Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Lysine N-methyltransferase 1D) Ehmt1 Euhmtase1 Glp Kmt1d Mus musculus (Mouse) TR9797_c0_g1_i1 Q05585 MSRE_RABIT 4.00E-12 GO:0005581; GO:0016021; GO:0034362; GO:0005044 collagen; integral to membrane; low-density lipoprotein particle; scavenger receptor activity IPR008160; IPR003543; IPR001190; IPR017448; Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (CD antigen CD204) MSR1 Oryctolagus cuniculus (Rabbit) TR9799_c0_g1_i1 P69003 ACT1_HELTB 9.00E-115 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin CyI, cytoplasmic" Heliocidaris tuberculata (Sea urchin) TR9807_c1_g1_i1 Q6AX80 ENPP4_XENLA 3.00E-25 GO:0047710; GO:0007596; GO:0016021; GO:0005886 bis(5'-adenosyl)-triphosphatase activity; blood coagulation; integral to membrane; plasma membrane IPR017849; IPR017850; IPR024873; IPR002591; Bis(5'-adenosyl)-triphosphatase enpp4 (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 4) (E-NPP 4) (NPP-4) enpp4 Xenopus laevis (African clawed frog) TR9820_c0_g1_i1 Q9CYH5 GFOD2_MOUSE 2.00E-75 GO:0031012; GO:0030198; GO:0016491; GO:0005578 extracellular matrix; extracellular matrix organization; oxidoreductase activity; proteinaceous extracellular matrix IPR016040; IPR000683; Glucose-fructose oxidoreductase domain-containing protein 2 (EC 1.-.-.-) Gfod2 Mus musculus (Mouse) TR9820_c1_g1_i1 O13991 YEG9_SCHPO 1.00E-10 GO:0006740; GO:0005634; GO:0016491 NADPH regeneration; nucleus; oxidoreductase activity IPR016040; IPR000683; IPR004104; Uncharacterized oxidoreductase C26H5.09c (EC 1.-.-.-) SPAC26H5.09c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR9834_c0_g1_i1 Q1ED21 NR2CA_DANRE 8.00E-45 GO:0007155; GO:0005634 cell adhesion; nucleus IPR000421; IPR008979; Nuclear receptor 2C2-associated protein (TR4 orphan receptor-associated 16 kDa protein homolog) nr2c2ap tra16 ch211-125m10.4 zgc:136330 Danio rerio (Zebrafish) (Brachydanio rerio) TR9846_c0_g1_i1 Q8I7D9 SC61G_CIOIN 3.00E-29 GO:0015450; GO:0005789; GO:0016021; GO:0006605 P-P-bond-hydrolysis-driven protein transmembrane transporter activity; endoplasmic reticulum membrane; integral to membrane; protein targeting IPR023391; IPR008158; IPR001901; Protein transport protein Sec61 subunit gamma SEC61G Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) TR9847_c0_g1_i1 P30175 ADF_LILLO 2.00E-14 GO:0015629; GO:0030042 actin cytoskeleton; actin filament depolymerization IPR002108; IPR017904; Actin-depolymerizing factor (ADF) Lilium longiflorum (Trumpet lily) TR9865_c0_g1_i1 P02595 CALM_PATSP 3.00E-41 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; IPR001125; Calmodulin (CaM) Patinopecten sp. (Scallop) TR9866_c0_g1_i1 Q9UHF1 EGFL7_HUMAN 8.00E-08 GO:0001525; GO:0005509; GO:0005576; GO:0005615; GO:0045746; GO:0030336; GO:0001938; GO:0001570 angiogenesis; calcium ion binding; extracellular region; extracellular space; negative regulation of Notch signaling pathway; negative regulation of cell migration; positive regulation of endothelial cell proliferation; vasculogenesis IPR000742; IPR001881; IPR013032; IPR018097; IPR013111; IPR011489; IPR009030; Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1) EGFL7 MEGF7 UNQ187/PRO1449 Homo sapiens (Human) TR9869_c1_g1_i1 Q8WUU4 ZN296_HUMAN 1.00E-07 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0007283; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; spermatogenesis; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 296 (ZFP296) (Zinc finger protein 342) ZNF296 ZNF342 Homo sapiens (Human) TR9877_c0_g1_i1 Q8NHV1 GIMA7_HUMAN 4.00E-07 GO:0005525; GO:0003924; GO:0005811 GTP binding; GTPase activity; lipid particle IPR006703; IPR027417; GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) TR9882_c1_g1_i1 Q5R4Q6 5HT2A_PONPY 4.00E-12 GO:0030424; GO:0007610; GO:0005901; GO:0016023; GO:0043198; GO:0005887; GO:0050795; GO:0046883; GO:0004993; GO:0007210; GO:0006939 axon; behavior; caveola; cytoplasmic membrane-bounded vesicle; dendritic shaft; integral to plasma membrane; regulation of behavior; regulation of hormone secretion; serotonin receptor activity; serotonin receptor signaling pathway; smooth muscle contraction IPR000455; IPR002231; IPR000276; IPR017452; 5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A) HTR2A Pongo pygmaeus (Bornean orangutan) TR9888_c0_g1_i1 P49916 DNLI3_HUMAN 9.00E-53 GO:0005524; GO:0003677; GO:0003910; GO:0051103; GO:0006284; GO:0051301; GO:0005694; GO:0006303; GO:0006273; GO:0043504; GO:0045910; GO:0005654; GO:0006289; GO:0007131; GO:0007283; GO:0000795; GO:0008270 ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligation involved in DNA repair; base-excision repair; cell division; chromosome; double-strand break repair via nonhomologous end joining; lagging strand elongation; mitochondrial DNA repair; negative regulation of DNA recombination; nucleoplasm; nucleotide-excision repair; reciprocal meiotic recombination; spermatogenesis; synaptonemal complex; zinc ion binding IPR001357; IPR000977; IPR012309; IPR012310; IPR016059; IPR012308; IPR012340; IPR001510; DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) LIG3 Homo sapiens (Human) TR9893_c0_g1_i1 P21328 RTJK_DROME 1.00E-07 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) TR9899_c0_g1_i1 P40429 RL13A_HUMAN 1.00E-87 GO:0006614; GO:0071346; GO:0022625; GO:1901194; GO:0017148; GO:0000184; GO:0003735; GO:0006414; GO:0006413; GO:0006415; GO:0019083 "SRP-dependent cotranslational protein targeting to membrane; cellular response to interferon-gamma; cytosolic large ribosomal subunit; negative regulation of formation of translation preinitiation complex; negative regulation of translation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; structural constituent of ribosome; translational elongation; translational initiation; translational termination; viral transcription" IPR005822; IPR023563; IPR023564; IPR005755; 60S ribosomal protein L13a (23 kDa highly basic protein) RPL13A Homo sapiens (Human) TR9900_c0_g1_i1 A1ZAJ2 KIF1A_DROME 1.00E-06 GO:0005524; GO:0048490; GO:0007411; GO:0005737; GO:0005871; GO:0008345; GO:0005874; GO:0005875; GO:0003777; GO:0007528; GO:0005543; GO:0016188; GO:0047496 ATP binding; anterograde synaptic vesicle transport; axon guidance; cytoplasm; kinesin complex; larval locomotory behavior; microtubule; microtubule associated complex; microtubule motor activity; neuromuscular junction development; phospholipid binding; synaptic vesicle maturation; vesicle transport along microtubule IPR000253; IPR022140; IPR022164; IPR027640; IPR019821; IPR001752; IPR027417; IPR011993; IPR001849; IPR008984; Kinesin-like protein unc-104 (Protein immaculate connections) (DUnc104) unc-104 imac CG8566 Drosophila melanogaster (Fruit fly) TR991_c0_g1_i1 Q8BYI9 TENR_MOUSE 5.00E-06 GO:0008306; GO:0009986; GO:0005737; GO:0030198; GO:0035641; GO:0060291; GO:0045121; GO:0048692; GO:0022408; GO:0050805; GO:0050885; GO:0007158; GO:0005634; GO:0072534; GO:0051968; GO:0005578; GO:0046625; GO:0050808; GO:0022029 "associative learning; cell surface; cytoplasm; extracellular matrix organization; locomotory exploration behavior; long-term synaptic potentiation; membrane raft; negative regulation of axon extension involved in regeneration; negative regulation of cell-cell adhesion; negative regulation of synaptic transmission; neuromuscular process controlling balance; neuron cell-cell adhesion; nucleus; perineuronal net; positive regulation of synaptic transmission, glutamatergic; proteinaceous extracellular matrix; sphingolipid binding; synapse organization; telencephalon cell migration" IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin-R (TN-R) (Janusin) (Neural recognition molecule J1-160/180) (Restrictin) Tnr Mus musculus (Mouse) TR9911_c0_g1_i1 Q9SMI3 RS12_CYAPA 1.00E-32 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR004038; IPR000530; 40S ribosomal protein S12 RPS12 Cyanophora paradoxa TR9911_c0_g2_i1 A4YIL9 RL7A_METS5 2.00E-09 GO:0003723; GO:0005840; GO:0003735; GO:0006412 RNA binding; ribosome; structural constituent of ribosome; translation IPR004038; IPR018492; IPR022481; IPR000948; 50S ribosomal protein L7Ae rpl7ae Msed_2132 Metallosphaera sedula (strain ATCC 51363 / DSM 5348) TR9918_c0_g1_i1 A1XQX1 NR1AB_DANRE 4.00E-06 GO:0007155; GO:0016021; GO:0007269; GO:0051965; GO:0090129; GO:0007416 cell adhesion; integral to membrane; neurotransmitter secretion; positive regulation of synapse assembly; positive regulation of synapse maturation; synapse assembly IPR008985; IPR013320; IPR001791; IPR003585; IPR027158; IPR027789; Neurexin-1a-beta (Neurexin Ia-beta) nrxn1a Danio rerio (Zebrafish) (Brachydanio rerio) TR9933_c0_g1_i1 Q62513 ZN260_MOUSE 9.00E-06 GO:0003677; GO:0005737; GO:0046872; GO:0007275; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cytoplasm; metal ion binding; multicellular organismal development; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; IPR013087; Zinc finger protein 260 (Zfp-260) Znf260 Zfp260 Mus musculus (Mouse) TR9935_c0_g1_i1 Q9NUV9 GIMA4_HUMAN 1.00E-09 GO:0005525; GO:0005829; GO:0005634 GTP binding; cytosol; nucleus IPR006703; IPR027417; GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) TR9937_c0_g1_i1 Q3THE2 ML12B_MOUSE 3.00E-57 GO:0030018; GO:0045177; GO:0005509; GO:0016460; GO:0008360; GO:0001725 Z disc; apical part of cell; calcium ion binding; myosin II complex; regulation of cell shape; stress fiber IPR011992; IPR018247; IPR002048; "Myosin regulatory light chain 12B (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2)" Myl12b Mrlc2 Mylc2b Mus musculus (Mouse) TR9941_c0_g1_i1 O46470 RGS7_BOVIN 2.00E-38 GO:0007186; GO:0005096; GO:0005737; GO:0044292; GO:0005834; GO:0035556; GO:0005634; GO:0005886; GO:0004871; GO:0038032 G-protein coupled receptor signaling pathway; GTPase activator activity; cytoplasm; dendrite terminus; heterotrimeric G-protein complex; intracellular signal transduction; nucleus; plasma membrane; signal transducer activity; termination of G-protein coupled receptor signaling pathway IPR000591; IPR015898; IPR024066; IPR016137; IPR000342; IPR011991; Regulator of G-protein signaling 7 (RGS7) RGS7 Bos taurus (Bovine) TR9948_c0_g1_i1 O97374 SCP_LYMST 1.00E-30 GO:0005576; GO:0007218 extracellular region; neuropeptide signaling pathway Small cardioactive peptides [Cleaved into: Small cardioactive peptide B (SCP B) (SCPb); Small cardioactive peptide A (SCP A) (SCPa)] SCP Lymnaea stagnalis (Great pond snail) TR9950_c0_g1_i1 Q98ST7 MOXD1_CHICK 7.00E-22 GO:0006584; GO:0005507; GO:0004500; GO:0005789; GO:0016021 catecholamine metabolic process; copper ion binding; dopamine beta-monooxygenase activity; endoplasmic reticulum membrane; integral to membrane IPR014784; IPR000323; IPR000945; IPR005018; IPR008977; DBH-like monooxygenase protein 1 (EC 1.14.17.-) (DBH-related protein) (Monooxygenase X) MOXD1 DBHR MOX Gallus gallus (Chicken) TR9951_c0_g1_i1 A6NK53 ZN233_HUMAN 9.00E-10 GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR001909; IPR007087; IPR015880; IPR013087; Zinc finger protein 233 ZNF233 Homo sapiens (Human) TR9953_c0_g1_i1 P41950 YLK2_CAEEL 9.00E-06 GO:0003391; GO:0005509; GO:0007160; GO:0032590; GO:0016021 amphid sensory organ dendrite retrograde extension; calcium ion binding; cell-matrix adhesion; dendrite membrane; integral to membrane IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR024731; IPR023413; IPR009030; IPR003886; EGF-like domain-containing protein D1044.2 D1044.2 Caenorhabditis elegans TR9959_c0_g1_i1 P29418 ATP5E_RAT 5.00E-11 GO:0006172; GO:0015986; GO:0016887; GO:0000275; GO:0046933; GO:0046961 "ADP biosynthetic process; ATP synthesis coupled proton transport; ATPase activity; mitochondrial proton-transporting ATP synthase complex, catalytic core F(1); proton-transporting ATP synthase activity, rotational mechanism; proton-transporting ATPase activity, rotational mechanism" IPR006721; "ATP synthase subunit epsilon, mitochondrial (ATPase subunit epsilon)" Atp5e Rattus norvegicus (Rat) TR9963_c1_g1_i1 A8MXQ7 YH010_HUMAN 1.00E-11 IPR002110; IPR020683; IPR000048; Putative IQ motif and ankyrin repeat domain-containing protein LOC642574 Homo sapiens (Human) TR9965_c0_g1_i1 P21329 RTJK_DROFU 1.00E-06 GO:0003723; GO:0006278; GO:0003964 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity IPR005135; IPR000477; RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) TR9969_c0_g1_i1 Q23551 UNC22_CAEEL 6.00E-13 GO:0031672; GO:0005524; GO:0046872; GO:0004674 A band; ATP binding; metal ion binding; protein serine/threonine kinase activity IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans TR9973_c0_g2_i1 O43301 HS12A_HUMAN 4.00E-06 GO:0005524 ATP binding Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) TR9977_c0_g1_i1 O01761 UNC89_CAEEL 6.00E-11 GO:0005524; GO:0031430; GO:0005089; GO:0005543; GO:0004672; GO:0035023; GO:0030241 ATP binding; M band; Rho guanyl-nucleotide exchange factor activity; phospholipid binding; protein kinase activity; regulation of Rho protein signal transduction; skeletal muscle myosin thick filament assembly IPR000219; IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR011009; IPR011993; IPR001849; IPR000719; IPR007850; IPR001452; Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans